SGTCid condition conc unit FRE5|YOR384W.score FRE5|YOR384W.strain.pval FRE5|YOR384W.strain.significant FRE5|YOR384W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2666 tannic acid 100 µM 7.59693798054308 8.3693885775348e-13 yes 1 1.51609881591905e-14 4 16134267 A thiamine antagonist.
SGTC_2627 acetyl isogambogic acid 100 µM 5.27225538747541 4.89239041687576e-07 yes 2 6.73786898458344e-08 23 6857789 A caspase activator and apoptosis inducer.
SGTC_817 1391-0715 46 µM 5.15894688065399 8.31941251479947e-07 yes 3 1.24171375387082e-07 5 1353946
SGTC_2994 9053520 71.4286 µM 5.07205089405733 1.24096713866148e-06 yes 4 1.96775548058087e-07 8 4647384
SGTC_776 4476-4378 112 µM 5.03451657240815 1.47206993694923e-06 yes 5 2.3952811721664e-07 10 2892008
SGTC_2106 5357045 167.29 µM 4.99284308734973 1.77695964935424e-06 yes 6 2.97484471252247e-07 6 668842
SGTC_972 1319-0219 195 µM 4.57836046494629 1.0679899013834e-05 yes 7 2.3431730649231e-06 10 23903702
SGTC_2478 5763493 32.33 µM 4.28713029408411 3.45792119666583e-05 yes 8 9.04980702545917e-06 19 1365576 YLR208W SEC13
SGTC_3265 9137266 49.47 µM 4.16102152951468 5.6275950500941e-05 yes 9 1.58413606194046e-05 7 17224265
SGTC_3043 9092303 49.47 µM 4.16048292053264 5.63915433037478e-05 yes 10 1.58787683454113e-05 12 25236084
SGTC_2953 9074162 66.49 µM 4.10822956712024 6.87345909767971e-05 yes 11 1.99351848777507e-05 19 16451992
SGTC_3318 9139014 38.6185 µM 4.10807369958692 6.87749540494098e-05 yes 12 1.99486401139891e-05 11 16643984
SGTC_117 lucigenin 22.078 µM 3.92323085423537 0.000136044768302567 yes 13 4.36846798445353e-05 83 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_265 mycophenolic acid 32.932 µM 3.84809918425994 0.000178081452514019 yes 14 5.95189305270234e-05 22 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.74626111764708 0.000254636715369257 yes 15 8.97448811289026e-05 22 6312947
SGTC_1612 st002233 45.4 µM 3.72293436147228 0.000276042764086816 yes 16 9.84603646773009e-05 24 1035021
SGTC_2965 9082772 38.63 µM 3.71944526144267 0.000279385070368501 yes 17 9.98304051585734e-05 46 16459634
SGTC_2424 5537928 59.2 µM 3.71548379429495 0.00028322554506081 yes 18 0.000101407632279946 43 5382802
SGTC_1341 1486-1360 280 µM 3.70512272193073 0.000293503858514803 yes 19 0.000105644204300602 33 3976547
SGTC_842 0271-0008 11.1 µM 3.66521148915359 0.000336429082350307 yes 20 0.00012356713657777 27 1221709
SGTC_2136 5328288 199.296 µM 3.61493474414198 0.000398810884015263 yes 21 0.000150211642184661 26 262395
SGTC_2184 6075246 200 µM 3.27813443583621 0.00118213274426925 no 22 0.000522478080571852 49 2267320
SGTC_2513 baicalein 25.65 µM 3.25661425672685 0.0012631791644349 no 23 0.000563747713187264 48 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_607 4491-0986 66.8 µM 3.20201730761291 0.00149211058994535 no 24 0.000682343991923688 42 698981 YDR232W HEM1
SGTC_3023 9089636 49.47 µM 3.18543329435853 0.00156879844168431 no 25 0.000722687104734477 16 17249241
SGTC_963 1269-2853 151 µM 3.16050768435337 0.0016908337279712 no 26 0.000787472253344037 57 3668223
SGTC_3200 9114385 49.47 µM 3.12804611938442 0.00186271343471948 no 27 0.000879862833033974 80 17018030 YLR208W SEC13
SGTC_3009 9080819 71.4286 µM 3.12025710603102 0.00190625053050246 no 28 0.000903466248796261 52 17027216
SGTC_1917 st066507 28.5 µM 3.08285191105657 0.00212849029308228 no 29 0.00102513577622871 92 3156428
SGTC_2333 9017922 200 µM 3.08049462320206 0.00214325337998561 no 30 0.00103328542959311 63 3163164
SGTC_2508 celastrol 40.54 µM 3.07273847445488 0.00219248584236274 no 31 0.00106052141757848 44 122724 Celastrol is a natural product and antioxidant.
SGTC_3270 9137563 49.47 µM 3.06523738035942 0.00224107213537216 no 32 0.00108748647673757 28 17015724
SGTC_2408 sulbentine 18.36 µM 3.06010458886862 0.00227487836136909 no 33 0.00110629854939046 93 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_245 methotrexate 289.6 µM 3.01474982452252 0.00259428070120033 no 34 0.00128595651141008 86 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2730 imipramine 71.33 µM 3.00536493301292 0.00266522886720903 no 35 0.00132631189161645 70 3696 A tricyclic antidepressant.
SGTC_2416 tofa 880 nM 2.9893577396497 0.0027902933613456 no 36 0.00139782299290556 102 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1613 st002381 52.1 µM 2.96156205519045 0.00302009686631829 no 37 0.00153041403348873 57 551167
SGTC_3319 9138450 16.7555 µM 2.95275545680229 0.00309638477942558 no 38 0.0015747567769765 61 2029690
SGTC_1964 st076914 61 µM 2.95137922083661 0.00310846205724653 no 39 0.00158179122186003 62 24208661
SGTC_114 0364-0001 490.298 µM 2.93981918793529 0.00321159440218056 no 40 0.00164201913160204 116 4003655
SGTC_1344 1488-0097 29.1 µM 2.93840257806144 0.0032244421085255 no 41 0.00164954162459175 56 747966
SGTC_1942 st076330 65.2 µM 2.93171973323674 0.00328567678894616 no 42 0.00168545402641261 78 24208414
SGTC_1340 1486-1359 257 µM 2.92907801962893 0.00331016972933524 no 43 0.00169984538552634 67 4309068
SGTC_2792 7535235 81.82 µM 2.9241512939696 0.0033562874008006 no 44 0.00172698412812112 79 1281891
SGTC_2714 st079313 56.9 µM 2.89648248597941 0.00362618115931294 no 45 0.00188685852984091 60 2939799
SGTC_773 4358-1457 44.6 µM 2.88822310028789 0.00371043858923717 no 46 0.00193712486415794 102 1186886
SGTC_3160 9100216 49.47 µM 2.88452723334532 0.00374870715546761 no 47 0.00196000925988934 28 17191039
SGTC_87 0100-0052 35.5 µM 2.87577206928253 0.00384077774965473 no 48 0.00201520317665025 249 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_342 k048-0088 23.3 µM 2.87181837110301 0.00388301574266719 no 49 0.00204058728641912 58 6820570
SGTC_2054 5233173 129 µM 2.86405348987296 0.0039671825116332 no 50 0.00209128687556105 131 6889
SGTC_3127 9126946 49.47 µM 2.84953615950719 0.00412893601298511 no 51 0.00218915143030971 60 27243249
SGTC_1048 3161-0300 24.5 µM 2.84321360907438 0.00420120874967255 no 52 0.00223305634474401 71 2165101
SGTC_1699 st031318 29.054 µM 2.83219809748448 0.00432983339876352 no 53 0.00231145992332804 70 5340658
SGTC_976 1348-1067 47.6 µM 2.81298706578288 0.00456259755114138 no 54 0.00245418127203573 93 5310671 YGL099W LSG1
SGTC_594 1487-1584 10.8 µM 2.81130246916623 0.00458353166113174 no 55 0.00246706885909324 68 5013332
SGTC_3266 9136860 49.47 µM 2.81004256829854 0.00459924416374908 no 56 0.00247674739112117 98 4871271 YPR165W RHO1
SGTC_136 0097-0015 404.482 µM 2.8027208421274 0.00469151011522319 no 57 0.00253367549191414 86 4861337
SGTC_392 N-ethylmaleimide 8.33 µM 2.77890004783751 0.00500322251977505 no 58 0.00272716526863963 63 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2030 5175110 200 µM 2.72924383131498 0.00571294293079386 no 59 0.00317398738180804 80 2831986
SGTC_3126 9127922 49.47 µM 2.72544375443446 0.00577077020055435 no 60 0.00321075582060044 114 45595682
SGTC_2284 7945075 39.21 µM 2.71419559800429 0.00594499367225083 no 61 0.00332184631982146 95 1245402
SGTC_741 4582-0002 126 µM 2.71086160073973 0.00599752258816956 no 62 0.00335543153524691 87 2912688
SGTC_197 4544-0043 41.561 µM 2.70990893378967 0.00601260775651528 no 63 0.00336508418946045 132 896523
SGTC_1718 roemerine 11.9335 µM 2.70339085809379 0.00611672468072865 no 64 0.00343179922234951 147 235224 An aporphine alkaloid with mutagenic activity.
SGTC_712 r015-0009 80.6 µM 2.68275713658794 0.00645692835130214 no 65 0.00365089973500065 78 6813872 YLR060W FRS1
SGTC_75 0159-0059 199.013 µM 2.63566241140927 0.00729680778959807 no 66 0.00419866145972919 99 5377270
SGTC_1631 benzylvanillin 81.9 µM 2.6236949662526 0.0075250141149569 no 67 0.00434908232000588 112 75506
SGTC_2330 7979373 200 µM 2.61363947523646 0.00772159788753325 no 68 0.00447917554016239 117 1863007
SGTC_579 4491-1009 110 µM 2.60982115426207 0.00779742141607482 no 69 0.00452947847660665 125 1271041
SGTC_1614 st002383 48.6 µM 2.60926923597022 0.00780843532688964 no 70 0.004536791073707 94 1947235
SGTC_744 1594-0068 283 µM 2.60208679732876 0.00795301889678687 no 71 0.004632919896504 128 668392
SGTC_730 1436-0052 41.2 µM 2.59233592136567 0.00815307052659768 no 72 0.00476633204640077 73 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2971 9092186 9.93 µM 2.58381329425011 0.00833153056606102 no 73 0.00488573375888419 108 25236400
SGTC_2093 5331342 194.4 µM 2.57061362828112 0.00861469714032125 no 74 0.00507592585917306 90 33839
SGTC_745 0469-0705 296 µM 2.57048953013115 0.00861739893570085 no 75 0.0050777448221471 116 3486736
SGTC_2932 9016711 44.54 µM 2.56481490467545 0.00874174040245055 no 76 0.00516154288217739 159 7117328
SGTC_2774 tamoxifen 10.92 µM 2.55381626735224 0.00898722632404436 no 77 0.00532747320716393 92 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2865 9030313 51.95 µM 2.54058727092365 0.00929047583204731 no 78 0.00553332355914027 89 42562754
SGTC_722 3534-0461 190 µM 2.53999827341942 0.00930418322815658 no 79 0.00554265080526483 143 658262
SGTC_2497 7-hydroxyflavone 100 µM 2.51677889641961 0.009858842865476 no 80 0.00592165626483252 103 5281894
SGTC_3155 9099265 49.47 µM 2.51580372552113 0.00988275641947853 no 81 0.00593806499357042 110 25236499
SGTC_2970 9090938 41.86 µM 2.50952448260057 0.0100379552060763 no 82 0.00604469174634382 182 17217104
SGTC_758 0868-0029 16 µM 2.50766880385728 0.010084225784198 no 83 0.00607652589193681 81 762687
SGTC_2331 7980721 200 µM 2.49616208828256 0.0103753172378812 no 84 0.00627726099427407 126 2981221
SGTC_1126 isoteolin 1.0172 µM 2.49503360653385 0.0104042556190862 no 85 0.00629726006601011 135 133323
SGTC_1766 st045414 44.774 µM 2.48970165764284 0.0105419397321777 no 86 0.00639251830699717 145 253960
SGTC_765 1319-0117 244 µM 2.47091441803197 0.0110398016704314 no 87 0.00673840333296035 95 3487746 YGL099W LSG1
SGTC_2085 5307070 144.047 µM 2.4687716654458 0.0110978637009685 no 88 0.00677888489668502 117 2840351
SGTC_3317 9138495 8.753 µM 2.46335819094039 0.0112457366958442 no 89 0.00688211659497742 124 17020139
SGTC_1054 3429-0080 167 µM 2.45466295998748 0.0114868386433546 no 90 0.00705083664763304 134 1162877
SGTC_2094 5332512 191.667 µM 2.4428462002539 0.0118216840099839 no 91 0.0072859729035612 136 755774
SGTC_13 0199-0087 65 µM 2.43470705102638 0.0120572154403369 no 92 0.00745192519473853 93 4589825
SGTC_725 1497-0963 19 µM 2.42702431003944 0.0122832613364286 no 93 0.00761161787556076 105 3549977
SGTC_2920 7982904 15.77 µM 2.42052151127396 0.0124774504725432 no 94 0.0077491311476743 120 6456808
SGTC_286 k060-0067 22.9 µM 2.42050239132587 0.0124780253371383 no 95 0.00774953867577356 116 5985051
SGTC_2958 9077254 16.72 µM 2.4195815022915 0.0125057401570423 no 96 0.00776918911462334 140 16457351
SGTC_1740 st038286 13.222 µM 2.4176999855161 0.0125625314956705 no 97 0.00780947431576145 144 716786
SGTC_153 4077-0274 519.67 µM 2.40036366145938 0.0130963978306512 no 98 0.00818939545017534 107 3121976
SGTC_397 arbidol 50 µM 2.39892316621895 0.0131416270323248 no 99 0.0082216822951781 126 131410 A RNA synthesis inhibitor.
SGTC_1885 st057546 99.9 µM 2.38582137475363 0.013559236077875 no 100 0.00852051292657101 145 702008
SGTC_1484 3473-2379 286 µM 2.37996877811382 0.0137494533405885 no 101 0.00865705248563827 128 671917
SGTC_3038 9091290 49.47 µM 2.37909180726276 0.0137781534613198 no 102 0.00867767643857024 131 25236843
SGTC_2202 7226349 200 µM 2.37866486020588 0.0137921446043756 no 103 0.00868773264959261 91 844334
SGTC_203 k066-0004 30.888 µM 2.37846947158011 0.0137985516160677 no 104 0.00869233819509218 154 6795412
SGTC_68 0986-0284 82.829 µM 2.3777758039663 0.0138213184920771 no 105 0.00870870607419746 212 423278 YIL048W NEO1
SGTC_251 melphalan 456.522 µM 2.37743541762279 0.0138325021619782 no 106 0.00871674775845444 165 460612 A DNA alkylator.
SGTC_1596 piperlongumine 63 µM 2.37188467961115 0.014015980476418 no 107 0.00884880670953208 118 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_8 0354-0001 70 µM 2.35579962306637 0.0145595613876125 no 108 0.00924144233498213 236 4993152
SGTC_1940 st075990 51.1 µM 2.3512992530623 0.0147148583901273 no 109 0.0093539906632681 168 1084979
SGTC_178 4092-0806 87.505 µM 2.34595922920028 0.0149009764393857 no 110 0.00948909165381901 263 2169044
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.3355099951815 0.0152710286216276 no 111 0.00975839718437947 145 688664
SGTC_3250 9135583 49.47 µM 2.33271909409311 0.0153711920018565 no 112 0.00983144668850965 97 7699353
SGTC_1665 st014639 11.4 µM 2.33073319450344 0.0154428075229092 no 113 0.0098837163477844 161 981133 YIL048W NEO1
SGTC_1972 st070201 17.4 µM 2.31851278607439 0.0158898344732815 no 114 0.0102107344411928 126 2829099
SGTC_1268 0828-0275 2.46 µM 2.31508505345209 0.0160171974423674 no 115 0.0103041389171149 155 745337
SGTC_2600 tangeritin 87.95 µM 2.30177711492398 0.0165200019987091 no 116 0.0106738723863238 145 68077 A bioactive flavone.
SGTC_125 0133-0007 11.75 µM 2.29275049438754 0.0168686869636596 no 117 0.0109311868220401 131 26541
SGTC_2682 pyrogallin 40.03 µM 2.28977481068813 0.0169850041193395 no 118 0.0110171870433668 181 822798 An ATP competetive kinase inhibitor.
SGTC_74 000s-0487 160.283 µM 2.28586846738173 0.017138740388521 no 119 0.0111309773378737 161 677548
SGTC_47 0149-0135 24.25 µM 2.28405808117672 0.0172103914165621 no 120 0.011184058862661 150 5239155
SGTC_2618 avocadyne 43.43 µM 2.2814502643938 0.0173140527278406 no 121 0.0112609082902833 138 3015189
SGTC_590 k048-0076 22.4 µM 2.27861560339637 0.0174273356077473 no 122 0.0113449627916341 126 6832814
SGTC_578 3460-0051 92 µM 2.27857226138433 0.0174290726057437 no 123 0.0113462522067697 154 2876744
SGTC_2900 5328528 85.29 µM 2.27752791087713 0.017470971282937 no 124 0.0113773599263589 178 795359
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.27638561890243 0.0175168977537455 no 125 0.0114114698264314 146 688669
SGTC_2598 perillyl alcohol 100 µM 2.27569774543141 0.0175446037710195 no 126 0.0114320531989867 183 10819 An apoptosis inducer.
SGTC_448 monastrol 171 µM 2.27321687861182 0.0176448385442644 no 127 0.0115065568258548 121 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1628 st004252 77.7 µM 2.26552658693534 0.0179586614780996 no 128 0.0117401921961899 166 692968
SGTC_2974 9094440 9.66 µM 2.24664733763151 0.0187493252540464 no 129 0.0123312871622004 188 25236134
SGTC_341 1486-1430 230 µM 2.246139618814 0.0187709912282577 no 130 0.0123475331742488 170 2054753 YPL210C SRP72
SGTC_2382 9035899 200 µM 2.23375568208927 0.0193060882825891 no 131 0.0127495765110197 151 6462679
SGTC_3148 9097893 49.47 µM 2.23007124380624 0.019467769774191 no 132 0.0128713567652009 178 17174100
SGTC_2955 9076254 12.21 µM 2.22495582557311 0.0196941518608342 no 133 0.0130421018912787 130 16459619
SGTC_1039 k821-0043 94 µM 2.22229534544932 0.0198127718712728 no 134 0.0131316762533113 161 15992768
SGTC_1439 4092-1168 46 µM 2.22003736829661 0.019913921097889 no 135 0.0132081155513572 129 2886240
SGTC_1714 st033236 13.627 µM 2.21545573833222 0.0201205086206099 no 136 0.013364399589315 174 2916566
SGTC_984 1492-0255 2.91 µM 2.20803115100302 0.0204591447023402 no 137 0.0136210508642823 160 1585198
SGTC_1737 st035557 69.7 µM 2.20717610386602 0.0204984518256637 no 138 0.0136508792742887 143 5716916
SGTC_1604 st002052 72.4 µM 2.19294511559881 0.0211621133032511 no 139 0.014155666833941 155 6254834 YHR062C RPP1
SGTC_364 0083-0097 67.7 µM 2.19056204639316 0.0212750055611439 no 140 0.0142417500971771 173 5207356
SGTC_2 0422-0095 29 µM 2.18789175685013 0.0214021088795925 no 141 0.0143387439466332 92 6790840
SGTC_2700 st077718 96.8 µM 2.18225301502383 0.0216726180008366 no 142 0.0145454322836893 136 904970
SGTC_259 usnic acid 108.925 µM 2.1815277881137 0.0217076183020889 no 143 0.0145722007154102 183 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_14 0354-0009 295 µM 2.17746948353615 0.0219043592887676 no 144 0.0147227781492162 176 1713507
SGTC_3007 9078383 71.4286 µM 2.17668857057801 0.0219423891000608 no 145 0.014751905822993 171 6496995
SGTC_2294 7971431 200 µM 2.17366111946809 0.0220903508777795 no 146 0.0148652973210239 143 5741572
SGTC_1954 st077032 68.9 µM 2.15815381211359 0.0228615137206797 no 147 0.0154579375448659 159 698907
SGTC_1047 2043-3044 82 µM 2.15388186432714 0.0230778957468677 no 148 0.015624718772589 210 669592
SGTC_300 r073-0011 5.04 µM 2.14920354537427 0.0233168371648926 no 149 0.0158091341865134 189 2735780
SGTC_3197 9113331 49.47 µM 2.14770827253679 0.0233936447628467 no 150 0.015868468891342 225 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1294 1000-1494 117 µM 2.14701145399397 0.0234295108635179 no 151 0.0158961848780795 183 712797 YDL207W GLE1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.14659106919242 0.0234511709500201 no 152 0.0159129257667614 211 5379071
SGTC_890 0929-0006 47.2 µM 2.14627567451005 0.0234674325400972 no 153 0.0159254955802703 165 1378169
SGTC_1114 scopoletin 1.73284 µM 2.12717195003885 0.0244702526597 no 154 0.0167028994165782 158 5280460 A coumarin with genotoxic properties.
SGTC_6 0844-0013 19.835 µM 2.12278484319595 0.0247055575398977 no 155 0.016885942755281 421 1584900
SGTC_2643 anethole 100 µM 2.12061500659852 0.0248226377396799 no 156 0.0169771071134407 190 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2870 9038528 12.99 µM 2.11812284452249 0.0249576838305837 no 157 0.0170823326449086 187 6463316
SGTC_2444 5485484 36.41 µM 2.1149411425351 0.0251309896964866 no 158 0.0172174820192681 228 6790631
SGTC_732 3970-1727 52.7 µM 2.10872629839408 0.0254724194013571 no 159 0.0174841067399455 151 1275699
SGTC_627 1391-0720 175 µM 2.1009557638283 0.0259047722274686 no 160 0.0178224247981697 175 997839
SGTC_3058 9093861 49.47 µM 2.0945314240054 0.0262668436733099 no 161 0.0181063334036965 206 17217477
SGTC_2993 9054257 71.4286 µM 2.09094899479141 0.0264705778421041 no 162 0.0182663182152034 264 6470217 YGL055W OLE1
SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.08427982902479 0.0268533735192351 no 163 0.0185673605139929 180 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2213 7173844 200 µM 2.08293509074124 0.0269311158653711 no 164 0.0186285702574402 177 892728
SGTC_2671 danthron 100 µM 2.07957659039015 0.0271260992367097 no 165 0.0187821930079266 212 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1225 1216-0074 20.6 µM 2.07585057239938 0.0273437963705071 no 166 0.0189538866781575 200 4241466
SGTC_1394 3474-0001 65.7 µM 2.06644018767574 0.0279001041075908 no 167 0.0193934672948582 179 5017666 YIL048W NEO1
SGTC_1701 st028638 40.4 µM 2.06555246211396 0.0279530664295029 no 168 0.0194353785248557 205 3490878
SGTC_3000 9075062 71.4286 µM 2.06263515106834 0.0281277053189064 no 169 0.0195736527148606 193 17057871
SGTC_856 0433-0016 11.3 µM 2.05684286638617 0.0284771415418915 no 170 0.0198506716028048 202 3911780
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.05203740562748 0.0287697789991633 no 171 0.0200830136524553 206 2333 A French combination drug.
SGTC_566 0958-0068 16.5 µM 2.05193747404363 0.0287758909575863 no 172 0.0200878696814851 178 6815365
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.04629845821649 0.0291225345132383 no 173 0.0203635076554254 198 66535 A nucleotide analog.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.04186281714739 0.0293976353332572 no 174 0.0205825705060141 220 3256 An antibiotic and ribosome inhibitor.
SGTC_2396 5342950 42.78 µM 2.03280773353358 0.0299659373521069 no 175 0.0210359757587457 272 1886677
SGTC_2285 7945142 200 µM 2.0252426151954 0.0304476865956952 no 176 0.0214212288851205 218 2970608
SGTC_693 4161-2696 114 µM 2.02080015283319 0.0307335622262759 no 177 0.0216502285036123 153 805759
SGTC_1967 st070177 51.4 µM 2.01322149833235 0.0312263819162024 no 178 0.0220456662740996 178 5729214
SGTC_2728 chlorpromazine 9.18 µM 1.99909300799408 0.032162569332694 no 179 0.0227991457581754 123 2726 A thorazine and dopamine antagonist.
SGTC_742 0kpi-0133 140 µM 1.99129072800938 0.0326894205975467 no 180 0.0232244671112571 225 2728852
SGTC_207 4185-0010 4.486 µM 1.98952653972092 0.0328095292022633 no 181 0.0233215577105929 315 3761753
SGTC_1801 st050089 28.441 µM 1.98743548283215 0.0329523624389438 no 182 0.0234370794283061 353 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1006 4099-6547 255 µM 1.98521645684516 0.0331044968940768 no 183 0.0235601970627443 223 3146833
SGTC_7 0192-1582 4.227 µM 1.9826130575486 0.0332837208760947 no 184 0.0237053338569244 314 252616
SGTC_2840 9008771 71.43 µM 1.97949342414599 0.0334995353418493 no 185 0.0238802396416453 144 2992978
SGTC_1611 st001856 99.4 µM 1.97913393239731 0.0335244786341579 no 186 0.023900464478344 219 647478
SGTC_638 3970-0837 4.09 µM 1.97831179058229 0.0335815803122777 no 187 0.0239467719059714 236 4118451 YLR208W SEC13
SGTC_668 1682-0499 62.6 µM 1.97311151535933 0.0339446215766509 no 188 0.0242414292987957 252 682214
SGTC_2006 4011487 200 µM 1.96858411162761 0.0342633111670149 no 189 0.0245004342827661 319 45595294
SGTC_146 3448-8650 53.125 µM 1.96592701389148 0.034451490037029 no 190 0.0246535210422266 415 2891488 YIL048W NEO1
SGTC_2576 guaiol 23.12 µM 1.96562481496116 0.0344729458082257 no 191 0.0246709827353102 241 227829
SGTC_441 propafenone 146 µM 1.96480085914786 0.0345315014870827 no 192 0.0247186453677623 168 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2340 7987427 183.45 µM 1.95735726972422 0.0350642033410112 no 193 0.0251527393020534 232 2239331
SGTC_3140 9094243 49.47 µM 1.95204486418123 0.0354484956706029 no 194 0.0254664391674764 246 19291112
SGTC_2232 chlorophetanol 41.5365 µM 1.95015742391997 0.0355858593067113 no 195 0.0255786793292621 370 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1746 st038117 42 µM 1.94943931020657 0.0356382364569094 no 196 0.0256214919365759 259 2898218
SGTC_473 2-arachidonoylglycerol 10 µM 1.94077515411282 0.0362751694579273 no 197 0.0261427779730351 239 5282280 An endocannabinoid.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.93945936938333 0.0363727076072504 no 198 0.0262227136833561 262 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2005 4024620 188 µM 1.92686892254301 0.0373169237146527 no 199 0.0269979836832675 219 236743
SGTC_2105 5350118 200 µM 1.92457346707616 0.0374912101592113 no 200 0.027141370725725 240 2133313
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.92292928864849 0.0376164554040397 no 201 0.0272444654471862 283 676296 Flavone; oxidizing agent.
SGTC_709 3807-1509 243 µM 1.9220134797543 0.0376863651147244 no 202 0.0273020308166083 183 1886677 YPL242C IQG1
SGTC_855 0428-0020 25 µM 1.92111649112566 0.0377549409300372 no 203 0.0273585115029643 205 6812414
SGTC_3275 9138069 49.47 µM 1.91453666312997 0.0382610957832502 no 204 0.0277758095849437 201 17617007
SGTC_433 pimozide 108 µM 1.90925350998908 0.0386714966944412 no 205 0.028114698214881 174 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_978 1416-0512 87.4 µM 1.90250686348554 0.0392007902787367 no 206 0.028552461212343 279 6814003
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.90194162053442 0.039245401593852 no 207 0.0285893935899748 225 688798
SGTC_950 1165-0508 94.1 µM 1.90053114606538 0.0393569022839795 no 208 0.0286817258155971 258 6148369
SGTC_1164 k060-0068 93.7 µM 1.90000890259398 0.0393982519539228 no 209 0.0287159756699848 276 5963676
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.89975929542296 0.0394180275801363 no 210 0.0287323574549522 197 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.89596229069937 0.0397198498321566 no 211 0.0289825155352276 512 16725076
SGTC_1530 rhein 70.4 µM 1.89175811248009 0.0400562274258299 no 212 0.0292616083132083 251 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2400 5203494 178.7 µM 1.88838955343823 0.0403274140268103 no 213 0.0294868363720878 239 6777674
SGTC_1617 st002906 78 µM 1.88766125927012 0.040386241104819 no 214 0.0295357201987962 273 5150859
SGTC_1116 jasmonic acid 1.58368 µM 1.88373823659985 0.0407043181686633 no 215 0.029800195815606 258 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_949 1165-0505 146 µM 1.87784418606503 0.0411860241163375 no 216 0.0302012417965823 290 6244267
SGTC_921 1561-0023 372 µM 1.87265893525035 0.0416136137252915 no 217 0.0305577486881347 254 24050882
SGTC_1123 mangostin 811.285 nM 1.86977871003624 0.0418526740065008 no 218 0.0307572770038653 299 5281650 An antioxidant.
SGTC_527 4476-4215 268 µM 1.86655098243102 0.0421218972783431 no 219 0.0309821590987626 281 4418754
SGTC_1407 3909-7909 12.3 µM 1.86157758557022 0.0425394679471955 no 220 0.0313313275759814 271 4411780
SGTC_581 0958-0271 211 µM 1.86090162126219 0.0425964800171306 no 221 0.0313790353975634 347 4591145
SGTC_2268 7933382 153.85 µM 1.86087029431239 0.042599123686784 no 222 0.0313812478286186 326 935025 YOR257W CDC31
SGTC_2978 9011784 42.97 µM 1.84925448608959 0.0435885592826473 no 223 0.0322105372229723 325 2994934
SGTC_1945 st075991 56.6 µM 1.84548102141232 0.0439139458754828 no 224 0.0324837983809163 253 1084980
SGTC_2725 haloperidol 53.21 µM 1.84350278587483 0.0440853106379302 no 225 0.0326278176711973 299 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_526 4469-0568 170 µM 1.83965399633243 0.0444202570257257 no 226 0.0329095257718548 285 2901964
SGTC_2800 7887935 81.82 µM 1.8385825724765 0.0445138631928284 no 227 0.0329883032620042 268 2961002
SGTC_927 2425-1185 123 µM 1.83213217515171 0.0450807726705226 no 228 0.0334658653777668 279 730375
SGTC_409 arachidonic acid 100 µM 1.83198946339384 0.0450933806474004 no 229 0.033476495215878 260 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.81381055353483 0.0467227548749649 no 230 0.034853448585241 282 4330530
SGTC_787 4152-0075 138 µM 1.81340866210374 0.0467593031026281 no 231 0.0348844072697451 279 9566539
SGTC_1666 st014829 29 µM 1.80666953013309 0.0473755870176619 no 232 0.0354069106312469 310 3858230
SGTC_2556 citropten 84.59 µM 1.79768180855902 0.0482076109230128 no 233 0.0361137229125563 329 2775 A potential DNA crosslinker.
SGTC_3164 9100705 49.47 µM 1.79057121101311 0.0488741123478246 no 234 0.0366810651624888 208 17174235
SGTC_1215 3852-0577 11.2 µM 1.78796027609581 0.0491206849580663 no 235 0.036891208484482 305 2884876
SGTC_155 k072-0202 43.6 µM 1.77166706081818 0.0506819140483057 no 236 0.0382249202780806 252 5857737
SGTC_726 3448-4391 34.2 µM 1.76791308870641 0.0510471661635206 no 237 0.0385377171638283 318 1356692
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.76734819136844 0.0511023101625662 no 238 0.0385849668715043 263 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1979 st071809 45.3 µM 1.75964717167728 0.0518588041969275 no 239 0.0392338240773408 279 4976333
SGTC_2736 butenafine 14.65 µM 1.75909849020733 0.0519130406510056 no 240 0.0392803906606077 344 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_233 rapamycin 362 pM 1.75874171141614 0.0519483319502917 no 241 0.0393106945926541 288 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_641 4092-0595 30 µM 1.73908080779886 0.0539227634003937 no 242 0.0410102750019815 310 786260
SGTC_2013 4024628 200 µM 1.73906053691946 0.0539248293254772 no 243 0.0410120575849329 315 5230760
SGTC_2773 thioridazine 9.09 µM 1.7374952852838 0.0540845426936283 no 244 0.0411498927485497 292 5452 An antipsychotic.
SGTC_2641 levomentholum 100 µM 1.73665057997535 0.0541708891885373 no 245 0.0412244329173995 220 16666
SGTC_1850 st056238 17 µM 1.73556292581085 0.0542822307491384 no 246 0.0413205730412527 338 5393177
SGTC_3215 9129942 49.47 µM 1.73181444284912 0.0546673453072577 no 247 0.0416533028939363 252 17682944
SGTC_154 3389-1638 511.116 µM 1.72933012256646 0.0549237694211175 no 248 0.041875014206101 287 5238686
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.72913092453359 0.0549443711419021 no 249 0.0418928327879747 310 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2636 apigenin dimethyl ether 100 µM 1.72907081170029 0.0549505894097216 no 250 0.0418982111824891 368 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1884 5633444 25 µM 1.72714834178747 0.0551497494298271 no 251 0.042070512789325 365 5724239
SGTC_1818 st052136 56.3 µM 1.72630123456812 0.0552376870612901 no 252 0.0421466166924386 345 674169
SGTC_3112 9123419 49.47 µM 1.7218061478431 0.0557061734857924 no 253 0.0425523202757721 336 17015854
SGTC_1363 1636-0063 10.4 µM 1.71900457503082 0.0559997412266124 no 254 0.0428067694381185 338 6072185
SGTC_2859 9028643 45.46 µM 1.71830983478191 0.0560727293004934 no 255 0.0428700582296988 277 17151580
SGTC_1503 4585-0012 61.3 µM 1.71819872765013 0.0560844089574342 no 256 0.0428801867725943 290 2922052
SGTC_2796 7949634 45.45 µM 1.71797373129869 0.0561080666026836 no 257 0.0429007033971451 330 2971588
SGTC_2823 7987624 58.44 µM 1.71572128220522 0.0563453383727565 no 258 0.0431065338091402 370 2239440
SGTC_2873 9040596 71.43 µM 1.71552969297426 0.0563655567223558 no 259 0.0431240781198458 348 6463863
SGTC_934 2950-0684 338 µM 1.71370039785983 0.0565588897270467 no 260 0.0432918819045369 336 1121253
SGTC_2156 5649887 115 µM 1.71326843198871 0.0566046191471187 no 261 0.043331583590122 353 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3068 9116768 49.47 µM 1.71168997949032 0.0567719674096829 no 262 0.0434769081183186 307 41904888
SGTC_2323 6148992 148.28 µM 1.71161100169849 0.0567803508976923 no 263 0.0434841897463154 279 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_750 4073-0104 132 µM 1.70702339120748 0.0572690010180627 no 264 0.0439088523968571 246 22330957
SGTC_1366 1683-0113 21.9 µM 1.70521156302225 0.0574628973942818 no 265 0.0440774871187681 293 708623
SGTC_3246 9135460 32.98 µM 1.70440202447238 0.0575496985169775 no 266 0.0441530029870926 235 41446951
SGTC_1908 st060353 56.5 µM 1.69997722294864 0.0580259625765591 no 267 0.0445676049606822 379 4227716
SGTC_67 0335-0847 266 µM 1.69860522526412 0.0581742651686905 no 268 0.044696795634323 497 4552207 YOR254C SEC63
SGTC_411 enrofloxacin 100 µM 1.69781886020418 0.0582593994532372 no 269 0.0447709775637461 304 71188 A bacterial gyrase inhibitor.
SGTC_1390 3413-2614 145 µM 1.69398170362912 0.0586762265149686 no 270 0.0451343799166724 341 3421432
SGTC_1304 1165-0502 251 µM 1.69223694635641 0.0588665305847179 no 271 0.0453004023361949 386 767425
SGTC_3178 9107506 49.47 µM 1.69219618111614 0.0588709827120819 no 272 0.0453042872188615 318 8897194
SGTC_1144 3486-0183 12.5 µM 1.69171831084147 0.0589231924522826 no 273 0.0453498477195045 344 6744069
SGTC_3349 9149703 23.001 µM 1.68770111003158 0.0593635294889123 no 274 0.0457343093081836 302 4910494
SGTC_2291 7917025 104.35 µM 1.68149831399687 0.0600484980775487 no 275 0.0463330818289346 375 2964612
SGTC_2183 6420625 130.508 µM 1.68062402365321 0.0601455407371914 no 276 0.0464179832405308 414 2897619
SGTC_679 0422-0091 41.4 µM 1.67978685440526 0.0602385781377692 no 277 0.0464993968636539 374 627384 YHR062C RPP1
SGTC_1805 st050013 60.3 µM 1.67086420623331 0.0612371941379155 no 278 0.0473742514675426 281 4037144
SGTC_428 3448-4153 16.5 µM 1.66935489276175 0.0614073872474178 no 279 0.0475235337243291 316 3834874
SGTC_1922 5578187 25 µM 1.66926878507455 0.0614171080469619 no 280 0.0475320617608446 345 1350412
SGTC_2067 5224629 34.075 µM 1.66700138767284 0.0616735100442183 no 281 0.0477570644714174 358 2835000
SGTC_2064 5220758 200 µM 1.66568589969003 0.0618226508044962 no 282 0.0478879959328152 385 788518
SGTC_2175 5807670 165.306 µM 1.66561014687837 0.0618312476895937 no 283 0.0478955444063329 316 241186
SGTC_2464 5717415 7.67 µM 1.66460492267373 0.0619454149510478 no 284 0.0479958013046592 348 5285744
SGTC_2135 5326629 150.42 µM 1.66383819169422 0.0620326061425839 no 285 0.0480723847404549 328 5020077
SGTC_1166 k206-0078 225 µM 1.65934960646342 0.0625449621395146 no 286 0.0485226823145621 368 5404595
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.65684083103303 0.0628327637546961 no 287 0.0487758297543796 292 17037758
SGTC_1001 4048-4355 44.4 µM 1.65250285807231 0.0633328406373545 no 288 0.0492160414911738 337 21824233
SGTC_1044 1222-0021 1.78 µM 1.65021877515477 0.0635973895899071 no 289 0.049449099046738 374 4306703
SGTC_313 3474-0040 5.03 µM 1.6443557937475 0.0642803932170076 no 290 0.0500513653718957 428 1043375 YIL048W NEO1
SGTC_2891 9063876 19.48 µM 1.64247351191068 0.0645008729408227 no 291 0.0502459555935652 236 6472478
SGTC_3083 9117465 49.47 µM 1.63360422011767 0.0655476859669399 no 292 0.0511709905703477 361 16420915
SGTC_1071 trifluoperazine 6.31 µM 1.63275875756591 0.065648156928524 no 293 0.0512598721132735 376 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2316 5844804 197.44 µM 1.63220754156083 0.0657137252265036 no 294 0.0513178863027716 461 776813
SGTC_1721 st082152 9.2685 µM 1.62866608513498 0.0661362004460753 no 295 0.0516918630317482 320 5296051
SGTC_1010 4112-3296 15.2 µM 1.62854205340313 0.0661510347578577 no 296 0.0517049999085109 400 704384
SGTC_1919 st067113 52.3 µM 1.62589956848275 0.0664676912081397 no 297 0.0519855109740723 387 1268243
SGTC_906 1165-0455 526 µM 1.62281160546349 0.0668392160591195 no 298 0.0523148420375507 320 3252859
SGTC_2580 diallyl disulphide 81.36 µM 1.62213320293969 0.0669210521612688 no 299 0.0523874151101067 339 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2726 cimetidine 79.27 µM 1.6188740404298 0.0673152879561805 no 300 0.0527371836898513 277 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_678 1218-2179 85.9 µM 1.61882448978616 0.0673212955413476 no 301 0.0527425156570243 280 6820081 YOR116C RPO31
SGTC_222 nsc-310342 10.666 µM 1.61807791791747 0.067411861069148 no 302 0.0528229033620014 210 432556
SGTC_2803 7707263 71.43 µM 1.61721380342963 0.0675168030582517 no 303 0.0529160688843081 328 2199229
SGTC_809 3998-0021 90 µM 1.6155389877607 0.067720559689696 no 304 0.0530970121836648 318 715485
SGTC_1627 st003713 25.6 µM 1.6154292279738 0.0677339295377491 no 305 0.0531088874910979 473 16195070 YER133W GLC7
SGTC_870 0573-2213 57.6 µM 1.61498569868541 0.0677879766419204 no 306 0.0531568959750339 318 3916321
SGTC_3108 9121785 49.47 µM 1.60958270319469 0.0684490462575665 no 307 0.053744493386631 355 17140271
SGTC_2842 9000675 19.48 µM 1.60669397020034 0.0688045243823231 no 308 0.0540607585031029 356 2989072
SGTC_905 2-aminofluorene 215 µM 1.60607280802416 0.0688811482013164 no 309 0.05412895682077 395 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1284 0929-0043 16 µM 1.60483419963155 0.0690341338015221 no 310 0.0542651487119097 397 1239883
SGTC_1901 st060216 58.6 µM 1.6035274567381 0.0691958187083581 no 311 0.0544091261335642 369 688792
SGTC_868 0527-0199 213 µM 1.60204506965128 0.0693795893437074 no 312 0.0545728217443794 375 2849450
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.60128792088867 0.0694735975434917 no 313 0.0546565815690454 393 16486 A toxic proline analog.
SGTC_129 0088-0017 176.636 µM 1.60061731152374 0.0695569428334183 no 314 0.0547308527984966 391 182446
SGTC_2194 5927483 104.545 µM 1.60011078738287 0.0696199461536473 no 315 0.0547870041596785 398 760979
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.59872441168623 0.0697926133228798 no 316 0.0549409254655765 329 688803
SGTC_2710 st078562 53.7235 µM 1.59808066151749 0.0698729016291238 no 317 0.0550125134234164 340 17250908
SGTC_2237 6667747 47.222 µM 1.58836490479903 0.0710932962937632 no 318 0.0561019243006618 336 729940 YDL015C TSC13
SGTC_228 caffeine 993.056 µM 1.58769444831448 0.0711781122148753 no 319 0.0561777245186971 314 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_719 2810-4230 27.3 µM 1.58755697954535 0.0711955122595193 no 320 0.0561932763829938 303 721079
SGTC_1065 prochlorperazine maleate 2.48 µM 1.58728843182939 0.0712295129813892 no 321 0.056223667022783 394 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_338 4055-0136 114 µM 1.58493634213907 0.0715278431078687 no 322 0.0564903991820397 381 2900563
SGTC_1151 3909-8316 15.3 µM 1.5842589649731 0.0716139366314151 no 323 0.0565673999091907 386 800431
SGTC_2777 climbazole 1.536 µM 1.58167202785533 0.0719434638210328 no 324 0.0568622307822093 410 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.58148644315887 0.0719671484476771 no 325 0.0568834281368423 451 688664
SGTC_1224 0823-0416 294 µM 1.58068829609603 0.0720690774502309 no 326 0.0569746628764366 371 3598164
SGTC_1120 ficusin 1.78878 µM 1.57811845724153 0.0723980158771396 no 327 0.0572691993481687 368 6199 A DNA cross-linker.
SGTC_1073 triclabendazole 3.09 µM 1.57189003113716 0.0732000236690212 no 328 0.0579880284376574 442 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3284 9108171 64.8615 µM 1.57119758136007 0.0732896056959036 no 329 0.0580683808600755 333 8687505
SGTC_748 act1.228 77.9 µM 1.57090636825648 0.0733273048925593 no 330 0.0581021995847013 448 4421505 YNR035C ARC35
SGTC_1274 0865-0114 173 µM 1.57022943881955 0.0734149945821027 no 331 0.058180871541647 383 870624
SGTC_332 4112-0506 40.9 µM 1.5594191575881 0.0748262526169802 no 332 0.059448602462227 379 2790355
SGTC_2216 7189485 200 µM 1.558071496909 0.0750036279192695 no 333 0.059608150270456 320 731273
SGTC_1176 0848-0131 83.3 µM 1.55578143328061 0.0753057748709901 no 334 0.059880037300852 423 6769040
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.54792696255352 0.0763491307186821 no 335 0.0608199411002571 351 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.54286723659459 0.0770270462768923 no 336 0.0614314958303242 393 803109
SGTC_106 0092-0003 11.579 µM 1.53606554928759 0.0779455503412003 no 337 0.0622611522922495 307 1072148
SGTC_1334 1486-0610 236 µM 1.53548689434565 0.0780240742375365 no 338 0.0623321369331802 418 3742339
SGTC_2534 helenine 20.12 µM 1.53533119127447 0.0780452135015205 no 339 0.0623512480807543 350 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2235 salicylic acid 500 µM 1.53431516006765 0.0781832632230609 no 340 0.0624760689642772 341 338 A COX inhibitor and kinase inhibitor.
SGTC_2068 5226020 147 µM 1.53151421066403 0.0785647915697893 no 341 0.0628211785143764 452 1810509
SGTC_1491 4138-0063 26.5 µM 1.52578859602609 0.0793490886378956 no 342 0.0635312608431096 355 23883227
SGTC_2466 5983409 37.09 µM 1.5257830349586 0.0793498532655929 no 343 0.0635319535421723 408 2879657
SGTC_2083 5306046 65.942 µM 1.52385076673526 0.0796158713025331 no 344 0.0637729972360547 440 539837
SGTC_2583 asiatic acid 100 µM 1.52353282825811 0.0796597069030526 no 345 0.063812727015619 377 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_695 3505-6186 243 µM 1.5184535020436 0.0803624945501784 no 346 0.0644500564397972 413 1819379
SGTC_2519 cryptotanshinone 88.04 µM 1.51751368869511 0.0804930414255221 no 347 0.0645685200358423 359 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1316 1272-0050 65.9 µM 1.51671719276377 0.0806038058448972 no 348 0.0646690508100971 389 7340392
SGTC_969 1313-0238 134 µM 1.5159820908588 0.0807061346449632 no 349 0.0647619404865022 463 5212874
SGTC_2210 7115885 190.385 µM 1.51419039585918 0.080955955880372 no 350 0.0649887784296315 413 2927039
SGTC_348 k064-0012 10.7 µM 1.5116007928933 0.0813180626684225 no 351 0.0653177249334281 373 5066323
SGTC_302 1094-0063 18.9 µM 1.51064224522158 0.0814524067385666 no 352 0.0654398122734297 347 5440289
SGTC_2903 5923464 63.88 µM 1.50993599886931 0.0815514968783036 no 353 0.0655298779365782 372 2876576
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.5072440042556 0.0819300317969654 no 354 0.0658740623659306 370 364106
SGTC_1337 1486-1011 40.3 µM 1.50720848174935 0.081935035631425 no 355 0.0658786134363732 385 X1337
SGTC_836 0330-0104 1.35 µM 1.50440001737234 0.082331375796217 no 356 0.0662391999074448 416 46494820
SGTC_121 0557-0495 61.343 µM 1.50402698834206 0.0823841273679639 no 357 0.0662872089120286 591 3104427
SGTC_486 niguldipine 82 µM 1.49950198056384 0.0830260555685098 no 358 0.0668717276446989 361 1236 A calcium channel blocker.
SGTC_2211 7117706 200 µM 1.4994422363484 0.0830345561144374 no 359 0.0668794717003654 387 822771
SGTC_517 1365-0151 113 µM 1.49590137180883 0.0835395284010432 no 360 0.0673396793943833 409 768657
SGTC_2307 7538926 6.34 µM 1.49365624352071 0.083860905617178 no 361 0.067632745390565 450 96582
SGTC_648 0375-0473 33.3 µM 1.48923792743116 0.0844960724969916 no 362 0.0682123633440471 466 1713139
SGTC_2205 7238770 200 µM 1.48845067070586 0.084609624535237 no 363 0.0683160410625829 366 279867
SGTC_1762 st045503 25.4615 µM 1.48709985943121 0.0848047289710979 no 364 0.0684942193341037 436 4645554
SGTC_1904 st060225 78 µM 1.48596444027439 0.0849689840249532 no 365 0.0686442635132553 406 66595
SGTC_799 1310-0557 151 µM 1.48372273154375 0.0852939801361275 no 366 0.0689412465916189 447 5354492
SGTC_1255 0566-0045 221 µM 1.47987963858352 0.0858533054608231 no 367 0.0694526852260337 461 2788469
SGTC_1158 4092-0494 91.8 µM 1.47874481482707 0.0860189920262941 no 368 0.069604264967944 445 1148199
SGTC_371 0195-0006 7.36 µM 1.47778469903789 0.0861593576138169 no 369 0.0697327075609456 361 3928593
SGTC_90 0870-0863 4.608 µM 1.47665014981267 0.0863254455392632 no 370 0.069884720639965 477 1738164
SGTC_1879 gemcitabine 100 µM 1.47623290743761 0.0863865862952955 no 371 0.0699406891364531 423 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1062 mesoridazine 14.2 µM 1.47341201581099 0.0868007963571043 no 372 0.0703199861228012 446 4078 A neuroleptic.
SGTC_2154 5570129 200 µM 1.4685434044018 0.0875191746608702 no 373 0.0709783375997481 487 673366
SGTC_3124 9127567 49.47 µM 1.45250120708341 0.0899176467020515 no 374 0.0731811468930224 413 17592030
SGTC_2881 9058953 51.95 µM 1.45094937399063 0.0901522278886402 no 375 0.0733969789454044 466 17122249
SGTC_2555 cholic acid 100 µM 1.44598837740494 0.0909052013193323 no 376 0.0740902308799031 429 6708657 Influences liver metabolism.
SGTC_1579 chlormadinone acetate 49.4 µM 1.445787287887 0.0909358205170727 no 377 0.074118436347009 461 45114258 A steroidal progestin.
SGTC_811 0416-0114 265 µM 1.44384661930958 0.0912317126459677 no 378 0.0743910624970667 446 6612453
SGTC_1738 st035555 74 µM 1.44178671296169 0.0915465652535104 no 379 0.0746812761803526 462 5331140
SGTC_1771 st048882 4.1505 µM 1.43977728998789 0.091854476769662 no 380 0.0749652091369678 433 4580403
SGTC_885 0865-0106 16.8 µM 1.4393438393968 0.0919209965136883 no 381 0.0750265638492779 470 2793380
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.43354017069256 0.0928150993464267 no 382 0.0758517637608319 449 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1238 0333-0287 48.8 µM 1.43307836121463 0.0928865201474668 no 383 0.0759177222881679 462 7226
SGTC_2150 5556613 200 µM 1.42978374863644 0.0933972253288952 no 384 0.0763895473900453 495 743190
SGTC_1050 3232-1156 69.3 µM 1.42836508982684 0.0936177725161898 no 385 0.076593400953594 474 700529
SGTC_2737 bleomycin 30.5 nM 1.42703839605974 0.0938243704129478 no 386 0.0767844137927315 527 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1248 0469-0687 58.6 µM 1.42157642927906 0.0946784743837887 no 387 0.0775746257127518 482 4017482
SGTC_201 4262-0159 12.803 µM 1.41140729706727 0.0962838943157779 no 388 0.0790622762908822 398 1341029
SGTC_141 0443-0274 32.331 µM 1.41055598441911 0.0964191947912537 no 389 0.0791877889159562 600 1627241
SGTC_1262 0737-0114 49.6 µM 1.41035033982429 0.0964518991545822 no 390 0.0792181305799765 551 765919
SGTC_1189 1431-2119 7.28 µM 1.41007689696162 0.0964953983319832 no 391 0.0792584891164714 507 3107275
SGTC_515 4092-1064 102 µM 1.40881504575886 0.0966963198347809 no 392 0.0794449325130484 538 717353
SGTC_369 0957-0393 4.5 µM 1.40747486872548 0.0969100492549913 no 393 0.0796433121252969 444 6997992
SGTC_2791 5663188 71.43 µM 1.40380074911146 0.0974977707976977 no 394 0.0801890954265772 452 54690634
SGTC_1324 1418-0026 34.4 µM 1.4032886110111 0.0975799008655738 no 395 0.0802653964963558 499 1372513
SGTC_1077 5-fluorocytosine 377 nM 1.4026260545185 0.0976862283450187 no 396 0.0803641890932567 447 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_48 0382-0018 55 µM 1.39523225743153 0.0988785575086436 no 397 0.081472906294183 443 762596
SGTC_935 2996-0153 430 µM 1.3821955503769 0.10100674400035 no 398 0.0834558329982779 468 23738523
SGTC_2299 7976368 114.88 µM 1.3808761179801 0.101223982295492 no 399 0.0836585270733154 469 2979718
SGTC_17 0960-0276 49.807 µM 1.37900491907414 0.101532649819715 no 400 0.0839466186234325 531 6821114
SGTC_94 0334-0113 514.748 µM 1.37694283164343 0.10187359906855 no 401 0.0842649617100914 479 6795178
SGTC_1848 st056003 16.4 µM 1.37445597698815 0.10228588763811 no 402 0.0846500841354122 514 146492
SGTC_188 3229-0966 278.469 µM 1.37273898572619 0.102571250072051 no 403 0.0849167523722374 587 5722370
SGTC_2002 4023503 131 µM 1.37140938140418 0.102792626422635 no 404 0.0851236873080092 620 4736863 YCR052W RSC6
SGTC_246 cycloheximide 667 µM 1.37101142881684 0.102858952160154 no 405 0.0851856966689112 420 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_860 0443-0016 25.1 µM 1.37051022317807 0.102942531055558 no 406 0.0852638431734639 487 5337942
SGTC_1358 1509-0022 2.48 µM 1.36844882950752 0.103286798944613 no 407 0.0855858143756699 506 3258434
SGTC_2926 9010726 65.15 µM 1.36725748843501 0.103486142408614 no 408 0.0857723058062354 514 2994293
SGTC_3166 9102297 49.47 µM 1.35884852686526 0.104901133741847 no 409 0.087097296232968 532 25237072
SGTC_2887 9044784 58.44 µM 1.35452838992751 0.105633514258224 no 410 0.0877839311352309 520 6465546
SGTC_472 calcifediol 10 µM 1.35430794698511 0.105670984214975 no 411 0.0878190759144205 423 5283731 A vitamin D metabolite.
SGTC_1817 st052116 64.4 µM 1.35399571822043 0.105724071979714 no 412 0.0878688718824035 486 4361398
SGTC_2721 ifenprodil 61.44 µM 1.35212670285143 0.106042260909564 no 413 0.0881673931858221 505 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1732 st034308 51.822 µM 1.35115655575342 0.106207695305386 no 414 0.0883226439525745 494 830119
SGTC_979 1426-2828 121 µM 1.342349534909 0.107718046510676 no 415 0.0897413446355101 554 747872
SGTC_3174 9107204 49.47 µM 1.34221687986159 0.107740913737422 no 416 0.0897628424546228 515 3938802
SGTC_1952 st077036 64.1 µM 1.33835711182844 0.108407796737261 no 417 0.0903900262994743 538 2937007
SGTC_2727 riluzole 51.77 µM 1.33765428295871 0.108529549070401 no 418 0.0905045801810286 461 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3169 9102970 49.47 µM 1.33609733361571 0.108799612506047 no 419 0.0907587307084727 495 17027839
SGTC_463 ikarugamyin 104 µM 1.3350778677544 0.1089767073656 no 420 0.0909254311577566 418 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_659 k018-0002 107 µM 1.33406139695766 0.109153488140545 no 421 0.091091867906871 530 6797879 YHR007C ERG11
SGTC_2420 aureobasidin a 50 nM 1.33285515537132 0.109363540392274 no 422 0.0912896707325082 559 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3024 9090631 49.47 µM 1.33130873917874 0.109633254421634 no 423 0.0915437219234416 468 25236383
SGTC_165 k038-0023 64.381 µM 1.32635227279709 0.110500940780433 no 424 0.0923615199023985 575 46368543
SGTC_616 4092-0450 108 µM 1.32405167749663 0.110905354955691 no 425 0.0927429412604929 557 787165
SGTC_142 0335-0849 62.6745 µM 1.31686772477688 0.112175020551576 no 426 0.0939414833638649 664 3889043 YPR107C YTH1
SGTC_1228 0124-0032 52.5 µM 1.31670393176072 0.112204089371753 no 427 0.0939689425989123 561 X1228
SGTC_3213 9129884 49.47 µM 1.31647290429464 0.112245099635992 no 428 0.094007683485426 453 17190742
SGTC_46 0329-0187a 2.197 µM 1.31529508446833 0.112454343905409 no 429 0.0942053747550454 635 46494817
SGTC_168 3970-0862 530.542 µM 1.3145224587972 0.112591755125863 no 430 0.0943352226365039 719 3135186
SGTC_118 0083-0097 135.343 µM 1.31367832708446 0.112742020711114 no 431 0.0944772386904514 774 5207356
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.31346575285058 0.11277988403888 no 432 0.0945130268456876 580 1377
SGTC_2782 7736369 71.43 µM 1.31202279561903 0.113037140898085 no 433 0.0947562216253228 569 2950836 YOL077C BRX1
SGTC_2228 7354201 200 µM 1.31077144398716 0.113260576293387 no 434 0.0949674964689826 504 753451
SGTC_3002 9075603 71.4286 µM 1.30853576885555 0.113660551752841 no 435 0.0953458253470251 561 20105405
SGTC_89 0302-0250 142.109 µM 1.30283083608508 0.11468575815583 no 436 0.0963162603787909 592 4203518 YLR208W SEC13
SGTC_760 0568-0725 82.9 µM 1.30137568034278 0.114948307296359 no 437 0.0965649469351988 552 3916171
SGTC_1406 3909-7906 11.9 µM 1.29937075580007 0.115310749330113 no 438 0.0969083613876267 558 X1406
SGTC_3271 9137798 49.47 µM 1.29879654820223 0.115414701696963 no 439 0.0970068797852301 471 6498326
SGTC_92 0063-0024 660.874 µM 1.29395607318632 0.116293650493647 no 440 0.0978402971046735 613 3594437
SGTC_2338 7999974 200 µM 1.29204867940161 0.116641302304152 no 441 0.0981701434991181 597 315925
SGTC_2997 9067075 71.4286 µM 1.28929420190623 0.117144647676465 no 442 0.0986479129711974 593 27209819
SGTC_778 3456-2434 196 µM 1.28370193698756 0.11817129135208 no 443 0.0996231332148634 651 5539063
SGTC_134 0269-0018 6.916 µM 1.28250934296642 0.118391051744286 no 444 0.0998320148028624 596 4378915
SGTC_2218 6965428 192.983 µM 1.27965858985332 0.11891753282946 no 445 0.100332617170194 570 675684
SGTC_956 1185-0240 191 µM 1.27893140434563 0.119052094742491 no 446 0.100460606288845 543 1416193
SGTC_1014 4130-3005 69.3 µM 1.27644872196998 0.119512312205212 no 447 0.100898471242664 587 743608
SGTC_3302 9125395 16.351 µM 1.27466114608135 0.11984445326599 no 448 0.101214602368997 545 17599668
SGTC_1421 4029-0249 71.4 µM 1.27193575771528 0.120352096451387 no 449 0.101697972850404 604 2894095
SGTC_140 0062-0056 502.533 µM 1.26974555955832 0.120761148976582 no 450 0.102087639216422 597 3758964
SGTC_2739 tacrine 100.86 µM 1.26431592454484 0.121779432402115 no 451 0.103058328046677 534 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_107 0358-0022 2.6945 µM 1.25938125165695 0.12271010935014 no 452 0.10394632898852 417 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2200 6600604 21.907 µM 1.25880163855532 0.122819750630316 no 453 0.10405099418557 611 2904777
SGTC_544 k015-0020 52.4 µM 1.25801286829337 0.122969067013023 no 454 0.104193551222161 552 3008304
SGTC_826 1683-5028 118 µM 1.25763014337835 0.123041563733392 no 455 0.104262773344163 562 722377
SGTC_554 4483-2211 187 µM 1.25723653362032 0.123116153534282 no 456 0.104333998931515 552 747107
SGTC_2674 ligustilide 100 µM 1.25706618937172 0.123148443918751 no 457 0.104364834476297 518 5319022 A signalling regulator.
SGTC_152 4469-0003 551.229 µM 1.25673251149889 0.123211712956777 no 458 0.104425255647245 565 697280
SGTC_1661 st013063 9.66 µM 1.25617272106168 0.123317906609864 no 459 0.104526677378492 637 721395
SGTC_2146 5545642 200 µM 1.25454719376513 0.123626636641568 no 460 0.104821591662425 586 825326
SGTC_2324 6149169 200 µM 1.25336700662024 0.12385112382608 no 461 0.105036086484315 537 2888231
SGTC_331 k048-0133 24.5 µM 1.25321346933021 0.123880349608486 no 462 0.105064014678597 516 6813582
SGTC_3040 9091894 49.47 µM 1.25187775537846 0.124134806077331 no 463 0.105307205759809 503 25236966
SGTC_2696 st077691 74.316 µM 1.25039452276708 0.124417793394052 no 464 0.105577732211358 520 757133
SGTC_994 3910-0338 138 µM 1.24943798256678 0.124600531672708 no 465 0.105752461697667 615 3479481
SGTC_1986 st071812 45 µM 1.24845026701542 0.124789422520096 no 466 0.105933105207273 535 11838594
SGTC_216 k038-0035 28.382 µM 1.24827404676494 0.124823143926944 no 467 0.105965357594594 534 4444231 YPR107C YTH1
SGTC_1920 st075728 45.7 µM 1.24792144188029 0.124890637312452 no 468 0.106029913758496 573 3400306
SGTC_592 k241-0073 46.5 µM 1.24749731948684 0.124971853898652 no 469 0.106107601245271 621 4230158
SGTC_903 1134-0042 114 µM 1.24648991247872 0.125164913440466 no 470 0.106292295160214 568 701009
SGTC_311 1315-0136 58 µM 1.24647162299783 0.125168420361537 no 471 0.106295650424009 595 6759207
SGTC_3204 9114183 49.47 µM 1.24363280091346 0.125713583066464 no 472 0.106817369165035 554 17027248
SGTC_2303 7774051 200 µM 1.24268370796043 0.12589621423531 no 473 0.10699220492289 563 2953184
SGTC_1651 st011928 86.1 µM 1.24074186038943 0.126270454621726 no 474 0.107350562529071 595 720198
SGTC_955 1216-0110 33 µM 1.24053512046921 0.126310343957658 no 475 0.107388766181143 634 3619719
SGTC_660 4031-1742 102 µM 1.23863491445195 0.126677389605147 no 476 0.107740365992463 624 6738706
SGTC_401 neomycin 50 µM 1.23801480374328 0.12679733138695 no 477 0.107855285881838 549 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3303 9125618 40.5795 µM 1.23733732938362 0.126928458796647 no 478 0.107980937376656 674 22695467
SGTC_423 5-fluorouracil 457 µM 1.23727373758262 0.126940772044892 no 479 0.10799273718775 570 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1761 st044296 37 µM 1.23715087231795 0.126964564738975 no 480 0.108015538148406 574 1826700
SGTC_572 0960-0087 17.7 µM 1.23432750775956 0.127512160841555 no 481 0.10854044484578 640 6796365
SGTC_1162 k048-0130 20.1 µM 1.233815701798 0.127611602000856 no 482 0.108635793544213 603 6797406
SGTC_510 ag-490 170 µM 1.23219479412594 0.127926891390668 no 483 0.108938163750636 626 5328779
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.22997078766611 0.128360372174741 no 484 0.109354022107508 529 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2629 bisabolol 100 µM 1.22753583269288 0.128836137173746 no 485 0.109810631264197 629 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2224 6650123 117.647 µM 1.22520102980058 0.129293480974257 no 486 0.11024974329185 552 2908370
SGTC_1367 1812-0510 76.9 µM 1.22501051988148 0.129330847860533 no 487 0.11028562844504 595 1142582 YDR527W RBA50
SGTC_2071 5230951 39.92 µM 1.22337402927713 0.129652139739408 no 488 0.11059422893033 634 1799272
SGTC_1270 0831-1170 17.3 µM 1.22004313222313 0.130307800810136 no 489 0.111224262245146 661 6764716
SGTC_3042 9091578 49.47 µM 1.21801893664823 0.130707366600396 no 490 0.111608388340487 562 25236497
SGTC_3099 9120367 49.47 µM 1.2163748563007 0.131032522332434 no 491 0.111921078822603 598 24824940
SGTC_2072 5231554 129 µM 1.21438297454369 0.1314272121371 no 492 0.112300756877285 606 789545
SGTC_3287 9117173 37.0625 µM 1.21334850271337 0.131632515417288 no 493 0.112498303128201 539 2789709
SGTC_3288 9119690 36.221 µM 1.20868060587775 0.132561667231615 no 494 0.113392787702586 535 17595618 YKL019W RAM2
SGTC_1668 st014914 51.6 µM 1.2071394025135 0.132869435913371 no 495 0.113689231313736 596 2839556
SGTC_2925 9010536 32.5 µM 1.19581801242146 0.135145327257615 no 496 0.115883792602745 685 2994177
SGTC_1277 0873-0036 22 µM 1.19447465004055 0.135417141210411 no 497 0.11614617556172 678 5965735
SGTC_3080 9117754 49.47 µM 1.19410210679583 0.135492587371246 no 498 0.116219014612858 686 9550191
SGTC_97 0535-0701 19.132 µM 1.19382906532591 0.135547901066901 no 499 0.116272419819609 583 2832013 YGL099W LSG1
SGTC_2435 5706476 10.6 µM 1.19077147297155 0.136168375589863 no 500 0.11687165535673 675 5725375
SGTC_1956 st077085 54 µM 1.18881603925717 0.136566207573594 no 501 0.117256032509238 666 24208685
SGTC_1432 4049-0298 68.4 µM 1.18861413482605 0.136607330153987 no 502 0.11729577155245 614 741646
SGTC_1828 st055811 49 µM 1.18632386485289 0.137074390244968 no 503 0.117747212794714 576 5877589
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.18410913966524 0.137527080833879 no 504 0.11818493132413 626 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2358 9037157 4 µM 1.18291044491914 0.137772519657458 no 505 0.118422320837595 636 2388925
SGTC_3205 9113483 49.47 µM 1.17993719514787 0.138382597112366 no 506 0.11901259748681 668 17018033
SGTC_2434 5670830 169.91 µM 1.17714398519154 0.138957407451111 no 507 0.119569020804524 634 1549830
SGTC_2404 5161160 200 µM 1.17665204134064 0.139058811933172 no 508 0.119667208567042 671 2831543
SGTC_1910 st062352 60.4 µM 1.17470485667786 0.139460679693664 no 509 0.120056407833317 636 2245730
SGTC_1106 tegaserod maleate 11.7 µM 1.17379831406892 0.139648044823602 no 510 0.120237909732919 673 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1887 st057648 70.8 µM 1.17198909543168 0.140022487405125 no 511 0.120600717104144 641 688672
SGTC_1524 corynanthine 62.1 µM 1.17161148270768 0.140100725504842 no 512 0.120676537902604 620 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_395 anisomycin 6.25 µM 1.1704922511553 0.140332795078696 no 513 0.120901465343101 566 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_460 trequinsin 123 µM 1.16932312435923 0.140575488913581 no 514 0.121136734900574 698 5537 A vasodilator.
SGTC_672 1441-0018 53.7 µM 1.16643636438197 0.141175958214642 no 515 0.121719031583056 613 251141
SGTC_1424 4048-1941 275 µM 1.16576747840942 0.141315339675365 no 516 0.121854234701525 710 X1424
SGTC_618 k072-0232 33.2 µM 1.16234402939311 0.142030173016034 no 517 0.122547874322326 625 5872756 YGL099W LSG1
SGTC_2678 equilin 100 µM 1.16199409905159 0.142103377871922 no 518 0.122618930948585 669 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1492 4158-0558 28.5 µM 1.16040357868406 0.142436433935369 no 519 0.122942265208544 629 3967268
SGTC_2172 5754775 163.918 µM 1.1541549098576 0.143750018673275 no 520 0.124218332407738 608 2263357
SGTC_1754 st042065 16.137 µM 1.14970104123211 0.144691277752809 no 521 0.125133512673959 776 1126236 YIL048W NEO1
SGTC_2973 9094665 17.96 µM 1.14966019490732 0.144699929183934 no 522 0.125141927503358 728 25237061 YIL048W NEO1
SGTC_390 dec-rvkr-cmk 16.7 µM 1.14745157966104 0.14516824238155 no 523 0.125597517024551 693 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1572 epiandrosterone 68.9 µM 1.14131637224258 0.146474494310797 no 524 0.126869145695322 728 441302 A steroid.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.13982218222037 0.146793814605177 no 525 0.127180195145878 742 4114 Related to psoralen; DNA damaging agent.
SGTC_582 0987-0078 156 µM 1.13855151214036 0.147065734090277 no 526 0.127445131020143 798 1625765
SGTC_2895 9054447 58.44 µM 1.13564246013404 0.147689533265556 no 527 0.12805311548367 651 2697450
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.13525018205739 0.147773786348022 no 528 0.128135254510612 758 65057 A dermal irritant. YDR527W RBA50
SGTC_2147 5545932 89.7195 µM 1.13420513523108 0.147998397486265 no 529 0.128354255231929 645 797404
SGTC_1547 harmine 94.2 µM 1.13328937484489 0.148195408946093 no 530 0.128546376120321 749 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1490 4089-0339 670 nM 1.12935546510747 0.149043723045213 no 531 0.129373955883176 649 742542
SGTC_2173 5763948 167 µM 1.12583565238214 0.149805485007433 no 532 0.130117545133162 703 2867177
SGTC_2270 7924575 90.91 µM 1.1229575442463 0.150430295154707 no 533 0.130727763067554 706 1262135
SGTC_2149 5554786 194.827 µM 1.12116560795375 0.150820183375843 no 534 0.131108688047627 719 745063 YPR165W RHO1
SGTC_2805 7950783 58.44 µM 1.12077424968373 0.150905424255681 no 535 0.131191983846137 736 1178958 YDL195W SEC31
SGTC_3350 9150499 3.57 µM 1.12045023174082 0.150976022148471 no 536 0.131260974735971 750 4910996 YPR165W RHO1
SGTC_1335 1486-0900 202 µM 1.11635000687825 0.151871288905337 no 537 0.132136172016822 718 X1335
SGTC_455 paf C-16 10 µM 1.11625256389645 0.151892607987272 no 538 0.132157020153825 667 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.11300622916047 0.152603994459461 no 539 0.132852877093524 700 16623 A steroid.
SGTC_2502 avocadyne acetate 18.59 µM 1.11027199550989 0.153204873718228 no 540 0.133440918436669 755 3952079
SGTC_1733 st037357 54.9 µM 1.10986805915757 0.153293776114489 no 541 0.133527943055821 679 1272339 YGL099W LSG1
SGTC_2557 derrustone 83.84 µM 1.10889032577333 0.153509107034102 no 542 0.133738748870312 710 629853 An antioxidant.
SGTC_1384 3089-0840 101 µM 1.10759541535558 0.15379459957389 no 543 0.134018292156007 661 1069836
SGTC_1784 st039334 36.3 µM 1.10693846624901 0.153939573283967 no 544 0.134160266729816 693 3496984
SGTC_1028 k015-0029 4.8 µM 1.10532434043128 0.154296158041018 no 545 0.134509537319398 701 4588309
SGTC_2481 5478948 45.16 µM 1.10360497893924 0.154676591264134 no 546 0.134882265224669 672 77792
SGTC_1772 st048439 82.2 µM 1.10257649143116 0.154904454800604 no 547 0.135105561941229 707 2927068 YDL195W SEC31
SGTC_1578 josamycin 24.2 µM 1.10205453761337 0.155020179518391 no 548 0.135218981157746 636 5282165 A P450 substrate.
SGTC_1861 st057647 17.4 µM 1.09402101323686 0.156808528218838 no 549 0.136972881148688 725 688668
SGTC_2558 carylophyllene oxide 100 µM 1.0937235131165 0.156875014592322 no 550 0.137038129307803 750 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1037 k284-1091 78.7 µM 1.08840899879785 0.158065845761977 no 551 0.13820729514129 661 3334711
SGTC_2759 disulfiram 3.38 µM 1.0872939741965 0.158316442120661 no 552 0.13845345540335 663 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1773 st048542 73.5835 µM 1.08599982115716 0.158607623396064 no 553 0.138739535684796 704 3237138
SGTC_1195 1502-0147 41.1 µM 1.08533263156502 0.158757876533007 no 554 0.138887179119832 744 817940
SGTC_1722 st034304 3.6505 µM 1.08491607017758 0.158851734732114 no 555 0.138979414877191 727 4036148 YLR033W RSC58
SGTC_2144 5628481 200 µM 1.08475665043948 0.158887664267562 no 556 0.139014724908222 677 2818399
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.08294472109187 0.159296405639322 no 557 0.139416480061109 673 279621
SGTC_2319 6033012 152.6 µM 1.08230934333195 0.159439899301261 no 558 0.13955754784953 663 847246
SGTC_270 tamoxifen 5.46 µM 1.07959008900181 0.160054971231034 no 559 0.140162378409492 793 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1146 3579-1023 7 µM 1.07952541482541 0.160069618837267 no 560 0.14017678521919 804 X1146
SGTC_305 1682-2595 20.8 µM 1.07713720521224 0.160611121634771 no 561 0.140709486888062 745 226033
SGTC_688 0527-0193 473 µM 1.076358100785 0.160788034356211 no 562 0.140883566686628 695 4007154
SGTC_2133 5320837 200 µM 1.07582282179107 0.160909654883595 no 563 0.141003251798146 679 2841355
SGTC_3118 9124250 49.47 µM 1.07162801652113 0.161864833613109 no 564 0.141943572170904 662 1504786
SGTC_191 3914-0123 66.505 µM 1.06595571300636 0.163162309342932 no 565 0.143221831088494 600 3144412
SGTC_1483 3453-0561 55.9 µM 1.06346146871768 0.163734973250788 no 566 0.143786364958441 767 4546991
SGTC_1404 3909-7820 48.3 µM 1.06299589863223 0.163842009741602 no 567 0.143891905641076 723 23741373
SGTC_1345 1488-0192 31.4 µM 1.06219296367785 0.164026714480184 no 568 0.14407404675085 761 658348
SGTC_3090 9117696 49.47 µM 1.06186812878322 0.164101476885719 no 569 0.144147777804571 734 7923821
SGTC_3334 9142812 21.919 µM 1.06080854050424 0.164345500142987 no 570 0.144388460064006 717 45283678
SGTC_3242 9133940 49.47 µM 1.06051696853749 0.164412690443147 no 571 0.144454737240194 758 17248444
SGTC_2376 9072922 81.32 µM 1.06018924687227 0.164488232389193 no 572 0.14452925606514 759 17087968
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.05658657199647 0.165320154739981 no 573 0.145350155752063 800 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1441 4106-0040 13 µM 1.05629970452779 0.165386514417409 no 574 0.145415655463854 753 2904180
SGTC_2212 7123476 200 µM 1.05526828423928 0.165625250285428 no 575 0.145651321005338 660 1085715
SGTC_2104 5389443 200 µM 1.05395889398695 0.165928646853643 no 576 0.14595086862893 780 2244536
SGTC_3001 9076041 71.4286 µM 1.04766630469045 0.16739169901481 no 577 0.147396188582378 726 16004211
SGTC_1506 4226-2149 212 µM 1.04627429844366 0.167716465498563 no 578 0.147717204078629 813 991114
SGTC_2930 9013230 14.89 µM 1.04525716584117 0.167954027276568 no 579 0.147952064470638 812 2995857
SGTC_1727 st034309 9.9045 µM 1.04218758009238 0.16867227298454 no 580 0.148662360056979 840 870305
SGTC_837 0091-0265 12.5 µM 1.04207030051329 0.168699754076387 no 581 0.148689543436838 788 759367
SGTC_3199 9111318 49.47 µM 1.04174595731607 0.168775769546382 no 582 0.148764737884841 770 8548020
SGTC_2694 st077685 81.9 µM 1.03780060249006 0.169702193885174 no 583 0.149681448142864 728 2838096
SGTC_2459 5811157 9.22 µM 1.03409668565967 0.17057488773319 no 584 0.150545482776794 757 2870684 YBR192W RIM2
SGTC_2421 5690543 90.72 µM 1.03240517299266 0.170974385459472 no 585 0.150941174808192 769 3397993
SGTC_698 k064-0052 127 µM 1.03191646013083 0.171089919946298 no 586 0.151055627162201 771 5088751
SGTC_1431 4049-0260 9.09 µM 1.03073510521194 0.171369405118348 no 587 0.151332528796028 787 3854841
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.03039351445303 0.171450273087733 no 588 0.151412658248112 765 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2157 5649910 96.377 µM 1.03037035755091 0.171455756119953 no 589 0.151418091353601 770 2858091
SGTC_2729 fluphenazine 10.66 µM 1.02992117541974 0.171562134488552 no 590 0.151523504753317 787 3372 An atypical antipsychotic.
SGTC_2553 4-methylesculetin 85.09 µM 1.02637942747894 0.172402392089861 no 591 0.152356385631285 779 5319502
SGTC_315 k915-0449 187 µM 1.0188767013169 0.174191020819109 no 592 0.154130752983062 867 20970215 YNL149C PGA2
SGTC_880 0833-0487 87.2 µM 1.01874097379575 0.174223486103434 no 593 0.154162977420717 753 76075
SGTC_2540 epiandrosterone 100 µM 1.01805786361036 0.174386940714305 no 594 0.154325229139944 923 441302 A steroid.
SGTC_1372 2752-0194 270 µM 1.01774067078087 0.17446287172688 no 595 0.154400606871333 735 823334
SGTC_1196 1588-0294 184 µM 1.01603353433684 0.174871894126304 no 596 0.154806708901118 736 6144269
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.01507051167943 0.175102898398532 no 597 0.155036108498994 854 688801
SGTC_2236 dapsone 200 µM 1.01218337328012 0.175796607787834 no 598 0.155725192240569 834 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_451 chloral hydrate 100 µM 1.00921991231102 0.176510463514253 no 599 0.156434589500555 849 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_683 panaxydol 45 µM 1.00766303598966 0.176886226527109 no 600 0.156808128008629 813 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_295 k015-0027 31 µM 1.00721780681815 0.17699377860415 no 601 0.156915058873972 781 3887424
SGTC_377 3970-0964 33.1 µM 1.00677586968206 0.177100576293097 no 602 0.157021246522345 884 16481235
SGTC_546 peri-Naphthalide 147 µM 1.00466072564743 0.177612281488448 no 603 0.157530122848282 790 223824 A penicillin ester.
SGTC_1250 0485-0349 40.2 µM 1.00279385255852 0.178064698207834 no 604 0.157980167767254 748 6842794 YDL195W SEC31
SGTC_499 genistein 192 µM 1.00271079480958 0.178084843231482 no 605 0.158000209996136 787 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1868 st057644 42.7 µM 1.00130202084649 0.178426749451511 no 606 0.158340408105273 857 688665
SGTC_2426 5582046 32.21 µM 1.00067898132108 0.178578091519596 no 607 0.1584910161054 819 2251934
SGTC_919 tnp00227 403.569 nM 0.999920494405327 0.17876244409647 no 608 0.158674492722569 829 1269246 A methoxyflavone. YNL221C POP1
SGTC_1134 3477-0009 42.5 µM 0.998785824553993 0.179038452682729 no 609 0.158949227203061 845 3973534
SGTC_2951 9072950 58.06 µM 0.997757646635092 0.179288788525646 no 610 0.159198446131663 884 16488155
SGTC_272 doxorubicin 8.13 µM 0.997501909614313 0.179351088319402 no 611 0.159260473674989 835 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1184 1269-1718 139 µM 0.996899158186966 0.17949797772307 no 612 0.15940673017058 812 5403821
SGTC_3045 9092950 49.47 µM 0.996667863655576 0.179554363841582 no 613 0.159462876690948 839 44120432
SGTC_3111 9122088 49.47 µM 0.994184766391317 0.180160406630527 no 614 0.160066461552881 685 16876704
SGTC_1878 temozolomide 1 mM 0.994132433067276 0.1801731932829 no 615 0.160079198654798 790 5394 DNA alkylating agent.
SGTC_1618 st003135 44.5 µM 0.993535959724893 0.180318970442859 no 616 0.160224417635093 789 1270615
SGTC_2198 6589944 200 µM 0.993195596567834 0.180402187827328 no 617 0.160307321927483 724 5290268
SGTC_3057 9095946 49.47 µM 0.992798126374066 0.180499398138768 no 618 0.160404171602111 826 24540043
SGTC_1302 1159-0335 255 µM 0.99242557796891 0.180590543089617 no 619 0.16049498340803 786 649284
SGTC_1242 0402-0103 60.1 µM 0.99219710732486 0.180646453311608 no 620 0.160550691660546 749 432868
SGTC_410 α-linolenic acid 100 µM 0.98901630058091 0.18142597199138 no 621 0.161327583217759 839 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1973 st070275 50.2 µM 0.987203977624809 0.181871057345452 no 622 0.16177132611863 799 17118334
SGTC_2775 cyproheptadine 69.59 µM 0.983010655096146 0.182903503782544 no 623 0.162801097295037 826 2913 A selective serotonin reuptake inhibitor.
SGTC_1682 st012968 530 nM 0.982880447091245 0.18293562100235 no 624 0.162833141094431 726 24207270
SGTC_354 2783-3500 4.88 µM 0.981642382787403 0.183241178822522 no 625 0.163138029892771 798 6740761
SGTC_2785 7756463 72.73 µM 0.981292100546519 0.183327687216847 no 626 0.16322435856012 814 2201551
SGTC_1027 k015-0025 8.67 µM 0.980814808528576 0.183445603903958 no 627 0.163342037142124 814 3598955
SGTC_2456 5770359 74.46 µM 0.97823133162511 0.184084681286999 no 628 0.163979961771624 853 3118787
SGTC_509 pifithrin 175 µM 0.977109834332432 0.184362538142329 no 629 0.164257389793803 885 4817 A p53 inhibitor.
SGTC_1909 st060837 51.5 µM 0.976596480133073 0.184489811355676 no 630 0.164384481189007 778 678937
SGTC_2504 purpurogallin 52.29 µM 0.976249362069515 0.184575901477903 no 631 0.164470453524915 789 5281571 An antioxidant.
SGTC_3348 9149464 3.537 µM 0.974958589590453 0.184896250181261 no 632 0.164790400744609 830 1951442
SGTC_1768 st044301 37.178 µM 0.97353919416582 0.185248919626088 no 633 0.165142695188231 836 3931349
SGTC_2980 9014342 25.29 µM 0.972670814979781 0.185464886884889 no 634 0.165358467396467 772 2996599
SGTC_2383 9036125 200 µM 0.971694655164867 0.185707845849078 no 635 0.165601238283589 808 79580
SGTC_1633 st005664 67.9 µM 0.969508655939949 0.186252640665475 no 636 0.166145731771504 839 2063822
SGTC_2370 9071495 200 µM 0.968709390264315 0.186452080685236 no 637 0.16634510303186 781 21791103
SGTC_1234 0326-0494 15.5 µM 0.967550452573983 0.186741504185305 no 638 0.16663446626796 839 1547813
SGTC_1926 methyl fluorone black 53.6 µM 0.967539624600828 0.186744209584242 no 639 0.166637171324079 753 72721 Reacts with homocysteine.
SGTC_1504 k297-0033 30 µM 0.96660214773001 0.186978532738717 no 640 0.166871480264174 698 4388117
SGTC_3054 9094397 49.47 µM 0.966536668235818 0.186994906188725 no 641 0.166887853864219 846 2598354
SGTC_375 3970-0961 9.27 µM 0.964294080988673 0.187556210818674 no 642 0.167449253788557 840 2898222
SGTC_1493 4348-0038 111 µM 0.964287258592957 0.187557920005734 no 643 0.167450963532994 892 800424
SGTC_3156 9099931 49.47 µM 0.963682810278034 0.187709388183241 no 644 0.167602487537543 885 18111053
SGTC_2182 6325192 200 µM 0.95655447747714 0.189501366309843 no 645 0.169396087539528 819 736248
SGTC_3016 9080866 49.47 µM 0.95551456954121 0.189763663863664 no 646 0.16965877052401 862 17066299
SGTC_2906 7926292 26.41 µM 0.954030097388869 0.190138481158352 no 647 0.170034203847957 834 2966319
SGTC_508 roscovitine 141 µM 0.95336530934881 0.190306482177397 no 648 0.170202505861227 873 160355 A CDKinase inhibitor.
SGTC_1867 st057372 64 µM 0.95150284858545 0.19077763680488 no 649 0.170674586586633 840 688837
SGTC_2193 5925765 200 µM 0.950208599367527 0.191105469688078 no 650 0.171003135001173 831 877370
SGTC_1723 st034307 2.5525 µM 0.948953370692873 0.191423748440789 no 651 0.171322164152674 849 867466
SGTC_469 w7 172 µM 0.947737384214842 0.191732386395082 no 652 0.171631582094499 840 45115570 A P450 inhibitor.
SGTC_1610 st001799 48.1 µM 0.946167152134272 0.19213138840157 no 653 0.172031668631624 780 621897
SGTC_1787 fluconazole 80 µM 0.941825684850151 0.193237213218096 no 654 0.17314094639187 863 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2214 7179297 48.276 µM 0.941567839925401 0.193303011452746 no 655 0.173206970728289 879 769744
SGTC_911 3456-4043 236 µM 0.941407240001803 0.193344001101808 no 656 0.17324810239887 884 914281
SGTC_1353 1498-1206 8.11 µM 0.939707949932678 0.193778032933502 no 657 0.17368369307868 907 6756808
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.938604723595261 0.194060136193539 no 658 0.17396686334039 871 4213774
SGTC_304 1310-0298 97 µM 0.937875696051145 0.19424669123862 no 659 0.17415414723773 873 1550234
SGTC_2575 plumbagin 510 nM 0.937403725805843 0.194367524635512 no 660 0.174275462580719 845 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2934 9036370 36.88 µM 0.936417886876097 0.194620065812956 no 661 0.174529036028608 893 6462800
SGTC_2260 7964312 200 µM 0.936381730206601 0.194629331817744 no 662 0.174538340551298 813 231951
SGTC_2827 7993847 71.43 µM 0.934872504097774 0.195016346250064 no 663 0.174927004347001 784 2985692
SGTC_2679 rapamycin 1 nM 0.933456804766792 0.195379802333087 no 664 0.175292081449207 937 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2378 9074213 121.43 µM 0.933136402170416 0.195462117171889 no 665 0.175374773089313 870 657714
SGTC_3201 9113999 49.47 µM 0.932965077455176 0.195506140956866 no 666 0.17541899986102 822 16649224
SGTC_2249 haloperidol 116.36 µM 0.931658005733568 0.195842205702014 no 667 0.17575664776195 976 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2296 7971656 126.45 µM 0.929136924474414 0.196491397113873 no 668 0.176409065376011 848 666570
SGTC_806 3966-4455 5.86 µM 0.927737318951978 0.196852365008276 no 669 0.176771922593725 785 714982
SGTC_1318 1280-3875 124 µM 0.927571663662938 0.196895115204726 no 670 0.176814901055285 885 373245
SGTC_1930 st074634 34.3 µM 0.924972390550878 0.197566638124454 no 671 0.177490134587948 862 684253 YOR116C RPO31
SGTC_2026 5148700 152 µM 0.922558399093063 0.198191531839148 no 672 0.178118691792768 890 79838
SGTC_1933 st074711 15.9 µM 0.922371029404962 0.198240084818316 no 673 0.178167537890813 933 17250958
SGTC_2388 9080168 200 µM 0.921927502324698 0.198355044296514 no 674 0.178283196252941 825 15943073
SGTC_2463 5473429 200 µM 0.921898612439158 0.198362533771607 no 675 0.178290731496661 859 5399405
SGTC_3078 9116413 49.47 µM 0.921852840496204 0.198374400136367 no 676 0.178302670436859 867 17177322
SGTC_1435 4092-0789 56.7 µM 0.92155346073207 0.198452024828374 no 677 0.178380771681947 907 2248285
SGTC_40 0327-0103 19.753 µM 0.920597708840316 0.198699959601108 no 678 0.178630249422875 842 409036
SGTC_2812 7970281 58.44 µM 0.920049469633663 0.198842264416827 no 679 0.178773454170907 892 2233435
SGTC_2835 9006588 71.43 µM 0.916694691974084 0.199714391446038 no 680 0.179651324180492 817 2345538
SGTC_3355 9151058 44.0485 µM 0.914837764921957 0.200198116620441 no 681 0.180138402937623 890 17015728
SGTC_1312 1218-2183 165 µM 0.91334207776728 0.200588251140864 no 682 0.180531329321042 928 6744073
SGTC_2320 7373003 200 µM 0.911524210570077 0.201063037082787 no 683 0.181009617552609 891 5415828
SGTC_2646 retinol 96.75 µM 0.909721833279596 0.201534442248293 no 684 0.181484613413028 885 445354 A vitamin A analog and teratogen.
SGTC_18 0111-0177 500 nM 0.907855684127413 0.20202322382748 no 685 0.181977236940948 1000 721752
SGTC_2087 5276107 200 µM 0.907096155923347 0.202222362343212 no 686 0.182177975356683 889 144405
SGTC_1568 digitonin 820 nM 0.906924997218211 0.202267254159494 no 687 0.182223230602807 954 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_221 trifluoperazine 10.304 µM 0.905387220971417 0.202670852216616 no 688 0.182630141672017 1017 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1903 st060211 78.3 µM 0.903362122403909 0.203203084359706 no 689 0.183166867990696 952 688960
SGTC_3291 9121177 71.43 µM 0.90285832937478 0.203335619658465 no 690 0.183300544524117 806 17015612
SGTC_2189 6047310 154.431 µM 0.902357845372728 0.203467335496987 no 691 0.18343340325893 872 711535
SGTC_2517 totarol 10 µM 0.899495994367541 0.204221485741436 no 692 0.184194264226482 849 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2311 7694451 200 µM 0.899332750048912 0.204264553739063 no 693 0.184237724024445 881 2163142
SGTC_664 1222-0054 14.9 µM 0.896574335769604 0.204993110946754 no 694 0.184973048878518 912 6813991
SGTC_483 fpl-64176 144 µM 0.895214240775733 0.205352909504545 no 695 0.185336286777401 871 3423
SGTC_3258 9138477 49.47 µM 0.894794869072229 0.205463925409531 no 696 0.185448376824012 920 4970355
SGTC_3004 9076122 71.4286 µM 0.894386613473391 0.205572032890606 no 697 0.185557536160144 922 44782551
SGTC_1183 1254-0324 198 µM 0.89254247953268 0.206060786497682 no 698 0.186051117184121 931 5799357
SGTC_1863 st057641 20.1 µM 0.891550263085793 0.206324039994611 no 699 0.186317019596322 981 3921635
SGTC_686 1319-0111 510 µM 0.890933267226019 0.206487840943577 no 700 0.186482485943725 963 4562600
SGTC_1978 st071761 42 µM 0.889721166079898 0.20680985554393 no 701 0.186807812932159 881 5147680
SGTC_1698 5-fluorocytosine 1.055 µM 0.88892797859298 0.207020739667541 no 702 0.187020893849014 949 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_830 4076-0286 57.8 µM 0.888739926385877 0.207070755610042 no 703 0.187071434005113 1023 6866659
SGTC_2608 thymoquinone 42.66 µM 0.88799845265023 0.207268033838375 no 704 0.187270791823789 876 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1678 st019265 80.2 µM 0.886665060850305 0.207623078682759 no 705 0.187629627238381 961 5367020
SGTC_913 3487-1245 167 µM 0.884167272586233 0.208289135917208 no 706 0.18830296120443 888 4016153
SGTC_422 cantharidin 155 µM 0.883526331205478 0.208460251595898 no 707 0.188475981150231 897 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2192 5915882 198.485 µM 0.88102864490867 0.209127863300186 no 708 0.189151158047987 908 2876149
SGTC_3337 9144342 33.5465 µM 0.879229867851264 0.209609440952993 no 709 0.189638326510834 943 17682949
SGTC_59 0330-0160 1.33 µM 0.878984956414802 0.209675060286578 no 710 0.189704716295985 1022 4293482
SGTC_1352 1496-0991 99 µM 0.877095753921126 0.210181641798073 no 711 0.190217315395931 936 3000039
SGTC_1485 3909-9022 254 µM 0.875983364717062 0.210480260131404 no 712 0.190519538673092 1001 714516
SGTC_361 000s-0510 1.45 µM 0.874792995187442 0.210800087757367 no 713 0.19084327464666 923 660
SGTC_1038 k292-0204 154 µM 0.871297355926575 0.211740939545129 no 714 0.191795906905364 876 4454212
SGTC_1744 st037937 38.9 µM 0.871255070255735 0.211752335761916 no 715 0.191807448398318 927 1016152
SGTC_504 lovastatin 124 µM 0.871242426028267 0.211755743519254 no 716 0.191810899608893 886 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2680 butyl paraben 22.24 µM 0.870229951949169 0.212028720492607 no 717 0.192087375299489 943 7184 An antifungal and steroid mimetic.
SGTC_81 0411-0046 9.971 µM 0.86994154315552 0.212106517124239 no 718 0.192166175517068 869 12925265
SGTC_1309 pyrazolanthrone 13.4 µM 0.869165044555481 0.212316056146644 no 719 0.192378431886727 998 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1411 3909-8223 150 µM 0.869134307484101 0.212324353068378 no 720 0.192386836832794 1009 X1411
SGTC_2259 7964009 200 µM 0.868593930264593 0.212470249162458 no 721 0.192534637790112 885 313134
SGTC_3343 9148379 18.9835 µM 0.866520387001235 0.213030627027877 no 722 0.193102425645601 983 1955036
SGTC_2115 tiliquinol 12.7705 µM 0.863324708445467 0.213895949863454 no 723 0.193979481411626 932 71208 A bioactive hydroxyquinoline.
SGTC_551 k048-0028 34.9 µM 0.862644355620094 0.214080439037613 no 724 0.194166517546922 993 6836383
SGTC_2779 methotrexate 400 µM 0.861159552331261 0.214483389997684 no 725 0.19457508684125 1038 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3289 9119912 71.43 µM 0.860565624574956 0.214644695524328 no 726 0.194738662716986 935 17014829
SGTC_88 0180-0332 8.668 µM 0.858111814001871 0.215311875730841 no 727 0.195415362224293 1028 3101745
SGTC_3292 9120825 59.784 µM 0.857335874333313 0.215523100448048 no 728 0.195629643844938 997 24824900
SGTC_175 3793-3120 23.7 µM 0.85567762094731 0.215974909450238 no 729 0.196088061042968 928 5322297
SGTC_1455 4262-0120 131 µM 0.853216427029304 0.216646498844828 no 730 0.196769647689509 1000 1529587
SGTC_1984 st072354 53.1 µM 0.853175690198607 0.216657624912932 no 731 0.196780941132872 961 5762938
SGTC_2128 5255449 168.493 µM 0.852960709780986 0.216716345969915 no 732 0.196840546506556 1026 736008
SGTC_2266 7929956 200 µM 0.85047363496824 0.217396349554376 no 733 0.197530906264502 976 2967153
SGTC_975 1335-0046 28.5 µM 0.849222261875886 0.217738959078811 no 734 0.197878814022791 990 16486740
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.848694870943699 0.217883445043515 no 735 0.198025550487409 1010 6728940
SGTC_3114 9122766 49.47 µM 0.848291268453257 0.217994054808627 no 736 0.19813788955411 878 17176985
SGTC_2161 5662504 8.5105 µM 0.846571662280557 0.218465686200604 no 737 0.198616957272558 922 2859334
SGTC_1646 st011709 75.6 µM 0.844014890999831 0.219168009668237 no 738 0.199330542264999 946 5757843
SGTC_124 0136-0217 7.121 µM 0.842256415073501 0.219651800602074 no 739 0.199822220902252 1128 3976905
SGTC_2565 isoliquiritigenin 100 µM 0.841567982450903 0.219841368713246 no 740 0.200014908620455 822 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2861 9024595 19.48 µM 0.839116186385016 0.220517262163508 no 741 0.200702056901108 939 16482810
SGTC_476 mead acid 10 µM 0.837412453481521 0.220987635335014 no 742 0.20118038401835 966 5312531 An omega 9 fatty acid.
SGTC_2979 9012552 45.46 µM 0.835169895835344 0.221607643867094 no 743 0.201811028472235 954 17100905
SGTC_1279 0874-0590 65.2 µM 0.833635540656843 0.222032425098521 no 744 0.202243195858541 985 3523074
SGTC_1013 4112-3890 241 µM 0.832876639945532 0.222242695984007 no 745 0.202457152750899 927 705171
SGTC_2977 9011197 71.43 µM 0.832043167925766 0.222473759431911 no 746 0.202692289403164 915 2704722
SGTC_603 3794-0023 45.9 µM 0.831977221812382 0.222492047519805 no 747 0.202710900889391 995 3802260
SGTC_997 3996-0078 137 µM 0.831674301524586 0.222576063980988 no 748 0.20279640497084 1025 735687
SGTC_711 k292-0785 179 µM 0.831427552659949 0.222644514382085 no 749 0.202866069694361 1035 4146315
SGTC_2489 cantharidin 73.42 µM 0.830518271250179 0.222896860957697 no 750 0.203122910919742 995 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_729 4092-0585 94.1 µM 0.830277594258562 0.222963681638525 no 751 0.20319092650361 964 2169061
SGTC_1827 berberine 7.24 µM 0.82801237034388 0.223593148926171 no 752 0.203831747134496 915 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1997 st073024 93.8 µM 0.827670640355782 0.223688197547023 no 753 0.203928525319081 1008 686268
SGTC_62 0180-0423 3.232 µM 0.827429966682658 0.223755152196099 no 754 0.20399670071091 994 30102 YGL099W LSG1
SGTC_1076 itraconazole 331 nM 0.824843500053901 0.224475417705516 no 755 0.204730223315438 1065 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_179 1273-0063 6.77 µM 0.822449698754986 0.225143201533492 no 756 0.205410501910378 993 3108139
SGTC_1292 0kpi-0043 232 µM 0.82056858185866 0.22566875373868 no 757 0.205946024866886 966 3333905
SGTC_3331 9141060 1.957 µM 0.817868755803337 0.226424250988303 no 758 0.206716066343549 980 4906567 YPR165W RHO1
SGTC_2040 5100729 123 µM 0.817378127937389 0.226561697482261 no 759 0.206856185523672 1011 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1488 4013-0813 75.9 µM 0.816476335423623 0.226814452125907 no 760 0.207113876440281 964 2910057
SGTC_766 1391-0721 126 µM 0.816390209499025 0.226838599841979 no 761 0.207138497207614 1021 1020919 YIL115C NUP159
SGTC_1670 st016595 4.04 µM 0.816263744534905 0.226874060319353 no 762 0.207174652809765 1056 597879
SGTC_1386 3228-0095 33.8 µM 0.816160597078202 0.226902984937788 no 763 0.207204144834997 990 870181
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.814402592329559 0.227396284488507 no 764 0.207707177024802 957 521171
SGTC_1495 4469-0029 237 µM 0.814351427316595 0.227410650532495 no 765 0.207721828081576 1058 793680
SGTC_669 0108-0021 26.2 µM 0.813737351655026 0.227583109761772 no 766 0.207897715737979 1106 17201
SGTC_2345 9052315 157.45 µM 0.812045134712323 0.228058738973292 no 767 0.208382866692222 998 6469265
SGTC_3184 9108758 49.47 µM 0.809580158273651 0.22875256589587 no 768 0.209090757838933 1014 902885
SGTC_1169 aniline yellow 25.8 µM 0.80905912911047 0.22889937366048 no 769 0.209240567915503 995 6051 A DNA damaging agent.
SGTC_1155 4088-0394 48.2 µM 0.808904043101198 0.228943081674125 no 770 0.20928517156686 993 2326248
SGTC_185 k048-0037 25.491 µM 0.806733934682483 0.229555176101571 no 771 0.209909894376662 1065 6827589
SGTC_1197 1601-0112 267 µM 0.803724544847937 0.230405511112874 no 772 0.210778037764387 1039 7350313
SGTC_3249 9135183 49.47 µM 0.800925233969926 0.23119806445728 no 773 0.211587465328828 1060 4902779
SGTC_2360 9040895 200 µM 0.796974221976427 0.232319276545333 no 774 0.212733001322957 981 4914414
SGTC_1560 lithocholic acid 53.1 µM 0.796676386321602 0.232403918324253 no 775 0.212819500770167 1001 9903 A bile acid which acts as a detergent.
SGTC_3235 9132602 49.47 µM 0.79271055901732 0.23353259830863 no 776 0.213973238477997 1095 4912240
SGTC_413 propylparaben 100 µM 0.792239137421195 0.233666967422314 no 777 0.214110626070407 1006 7175 A pharmaceutical preservative.
SGTC_523 1934-0222 13.7 µM 0.79223607630142 0.233667840072133 no 778 0.21411151834803 1027 1361595
SGTC_336 4111-0029 111 µM 0.792207027635803 0.233676121220838 no 779 0.214119985773649 983 3131175
SGTC_1265 0819-1001 68.8 µM 0.79072832804198 0.234097881494941 no 780 0.214551270813952 1045 3106768
SGTC_2712 st079126 47.7 µM 0.790325712348773 0.23421279003543 no 781 0.214668787163798 1037 3152970
SGTC_879 0831-1030 162 µM 0.790028299479897 0.234297693211001 no 782 0.214755620700921 1048 1549252
SGTC_608 k048-0125 159 µM 0.789151390260174 0.234548125755681 no 783 0.215011764465669 1086 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1369 1866-0067 208 µM 0.788819178985426 0.234643039131483 no 784 0.215108849157733 1090 3531355
SGTC_1371 2421-0008 32.7 µM 0.788674816535507 0.234684290369892 no 785 0.215151045253684 1003 2827552
SGTC_2762 leflunomide 42.06 µM 0.788558204058773 0.234717615044905 no 786 0.21518513374193 1050 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1412 3909-8563 178 µM 0.788018248753732 0.234871953688478 no 787 0.215343015859927 1145 23767530
SGTC_710 3448-4187 58 µM 0.786764956652527 0.235230405729724 no 788 0.215709735533193 1093 3946412
SGTC_1063 disulfiram 1.84 µM 0.786729948644827 0.235240422647953 no 789 0.215719984250084 1068 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1328 1441-0025 69.2 µM 0.786021076199355 0.235443304540197 no 790 0.21592756986119 1024 4562601
SGTC_1339 1486-1321 22.7 µM 0.78591873605563 0.235472602638955 no 791 0.215957548621095 1033 3469382
SGTC_1185 1319-0113 81.3 µM 0.785572763732265 0.23557166303976 no 792 0.216058913032248 1040 4672763
SGTC_1755 st041960 45.185 µM 0.78533686744146 0.23563921913985 no 793 0.216128042707682 1043 2257073
SGTC_530 4358-1714 28 µM 0.784058282958303 0.236005566675184 no 794 0.21650295614699 1070 1564641
SGTC_1899 st063254 59.6 µM 0.781341831692078 0.236784940956873 no 795 0.217300736476889 986 3093813
SGTC_2437 5741531 144.16 µM 0.781216755817451 0.236820860402652 no 796 0.217337510192831 1131 2262990
SGTC_1117 retinoic acid 1.10837 µM 0.779500795950995 0.237313954301895 no 797 0.21784238444931 1095 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2816 7982706 58.44 µM 0.777863340323791 0.237785014656531 no 798 0.218324791089609 1045 2981853
SGTC_393 acivicin 6.25 µM 0.775617877964069 0.238431818315801 no 799 0.218987320616899 990 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2312 7706453 155.7 µM 0.774821091157797 0.238661563482186 no 800 0.219222692319879 1047 976098
SGTC_2703 st077852 53.4 µM 0.771729201064446 0.239554223774028 no 801 0.220137415921071 1038 6281836
SGTC_3091 9116372 49.47 µM 0.771608344802011 0.239589153190413 no 802 0.220173215174695 1047 17169793
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.771414174837757 0.239645277274484 no 803 0.220230737925404 1085 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1448 4255-0083 152 µM 0.771175362835077 0.239714314807457 no 804 0.220301497672725 1126 5399660
SGTC_2645 abamectin 100 µM 0.767693502317596 0.240722108307897 no 805 0.221334648687641 1086 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2995 9067767 71.4286 µM 0.767581853107326 0.240754462287748 no 806 0.221367823455059 1046 11673567
SGTC_576 1073-0113 22.7 µM 0.767397725334645 0.240807824450643 no 807 0.221422540272526 1272 5439563
SGTC_2611 pyromycin 23.93 µM 0.767166859630493 0.240874740849102 no 808 0.221491157016202 1083 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2267 7931562 200 µM 0.767069274764007 0.240903028853032 no 809 0.221520164354044 1013 934880
SGTC_250 brefeldin a 552.239 µM 0.766186949015628 0.241158880388536 no 810 0.221782536379085 1001 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_605 1315-0399 119 µM 0.765785546895413 0.241275325437526 no 811 0.221901957695731 1117 24020461
SGTC_3228 9131799 49.47 µM 0.764163009573634 0.241746327838882 no 812 0.222385053530221 1034 17015818
SGTC_363 0455-0021 3.06 µM 0.763797851282771 0.241852397498644 no 813 0.22249385875429 1091 4597466
SGTC_847 0342-0274 5.54 µM 0.76341710398398 0.241963022274877 no 814 0.22260734131462 1123 18097
SGTC_2592 piperlongumine 83.33 µM 0.762777206162544 0.242149004125924 no 815 0.222798138562582 1053 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2023 5144124 124 µM 0.761226612049324 0.242599994784047 no 816 0.223260862859345 1073 2830192
SGTC_2062 5245942 200 µM 0.760511393743543 0.242808169373124 no 817 0.223474480663607 1196 1376160
SGTC_2239 6685329 187.64 µM 0.760447147924256 0.242826873775074 no 818 0.223493674971252 1053 805680
SGTC_1096 rimcazole 32.2 µM 0.760158569975133 0.242910899410338 no 819 0.223579903103423 1014 18528119 A dopamine reuptake inhibitor.
SGTC_2415 st077333 57.7 µM 0.75969022853055 0.243047300503594 no 820 0.223719885479426 1144 2766255
SGTC_2279 7948423 32.93 µM 0.759359815745665 0.243143555778087 no 821 0.22381867238599 1083 1247112
SGTC_1502 4534-4282 27.7 µM 0.758294265945678 0.243454110250731 no 822 0.224137419612988 1061 3278949
SGTC_414 piperonyl butoxide 100 µM 0.757870408661802 0.243577702998549 no 823 0.224264283385389 1107 5794 A potent inhibitor of cytochrome P450.
SGTC_843 0310-0051 143 µM 0.757205592855287 0.24377162519479 no 824 0.224463350010303 1104 2065037
SGTC_2585 alliin 100 µM 0.757091530299841 0.243804904831071 no 825 0.224497513978401 1132 87310 A garlic compound which reacts with lipids.
SGTC_3222 9128301 49.47 µM 0.756385796352445 0.244010868891055 no 826 0.224708960703731 1149 4911358
SGTC_318 1488-0629 67.2 µM 0.755816204292822 0.244177169211269 no 827 0.224879699950395 1066 3662576
SGTC_635 k038-0028 24.7 µM 0.755614469077262 0.244236083263624 no 828 0.224940189139373 1103 4035102
SGTC_943 3253-1379 105 µM 0.754157348576106 0.244661843159849 no 829 0.225377372444126 1071 668464
SGTC_344 k064-0035 6.43 µM 0.752867912669821 0.245038939916361 no 830 0.225764645848315 1081 5088750
SGTC_2581 avocatin a 64 µM 0.751721038993276 0.245374606751836 no 831 0.226109417711132 1095 6710728 A skin care supplement.
SGTC_1415 3966-0071 78.1 µM 0.751162253646734 0.245538241463158 no 832 0.226277506877564 1107 2893185
SGTC_1343 1487-0095 224 µM 0.749311398298741 0.246080664383462 no 833 0.226834769664424 1108 4560101 YGL055W OLE1
SGTC_2082 5219693 150 µM 0.748825192946575 0.246223261207727 no 834 0.226981286578568 1141 2834649
SGTC_2849 9019321 12.99 µM 0.746809587166589 0.246814880773345 no 835 0.227589253838776 1072 16489627
SGTC_3154 9100113 49.47 µM 0.745589601631592 0.247173339650274 no 836 0.227957683127257 1118 25237525
SGTC_2935 9038016 29.96 µM 0.744473512125593 0.247501515268726 no 837 0.228295030026515 1131 6463195
SGTC_1022 4477-0945 21.3 µM 0.743460888913254 0.247799468918924 no 838 0.228601346052223 1091 4648966
SGTC_54 0159-0055 9 µM 0.742870583354301 0.247973248388694 no 839 0.228780018477691 1132 3319099
SGTC_1486 3970-0793 4.53 µM 0.739532760900167 0.248957088898355 no 840 0.229791777004743 1151 2844330
SGTC_1165 k072-0275 30.3 µM 0.738868810828626 0.249153039038105 no 841 0.229993331443159 1152 6153523 YGL055W OLE1
SGTC_2825 7998094 58.44 µM 0.738098888925382 0.249380367089809 no 842 0.230227179445732 1078 2987815
SGTC_189 3970-0742 2.116 µM 0.736507927335899 0.249850465365519 no 843 0.230710822501481 1150 2891807
SGTC_2890 9046729 58.44 µM 0.734610093643367 0.250411853083164 no 844 0.2312884944947 1067 903329
SGTC_3128 9127691 49.47 µM 0.728713616982553 0.252160313954999 no 845 0.233088430757593 1051 41316314
SGTC_567 1080-0542 68.4 µM 0.725815921523549 0.253021910843022 no 846 0.233975812540777 1096 5950415
SGTC_3017 9080681 49.47 µM 0.72563378062627 0.253076120067895 no 847 0.234031653282136 1125 16451914
SGTC_1264 0783-0040 158 µM 0.725578870783021 0.253092463669935 no 848 0.234048488985362 1083 2855798
SGTC_3105 9121040 49.47 µM 0.725268983361174 0.253184710303263 no 849 0.234143514991609 990 41448907
SGTC_3240 9133527 49.47 µM 0.723132625740945 0.253821137548737 no 850 0.234799203331862 1126 17617455
SGTC_1204 4049-0315 18.3 µM 0.721492843447829 0.254310202624227 no 851 0.235303171110039 1120 588402
SGTC_2361 9034121 116 µM 0.718954696360385 0.255068177972914 no 852 0.236084416889629 1143 6496917
SGTC_1684 st024538 14.6195 µM 0.716940507058825 0.255670521984416 no 853 0.236705403218617 1161 6732859
SGTC_914 3820-6779 408 µM 0.715987493103358 0.255955779790801 no 854 0.236999535812109 1163 2893481
SGTC_1803 st050068 52.4 µM 0.71290332689423 0.256880074864325 no 855 0.237952790177366 1255 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2099 5377090 177.372 µM 0.712183669155501 0.257095999054907 no 856 0.238175524141646 1155 2243829
SGTC_2638 epoxomicin 18 µM 0.711952698992784 0.257165318729943 no 857 0.238247033580488 1158 9915668 A protesome inhibitor.
SGTC_2917 7979103 53.79 µM 0.711771644658065 0.257219664263996 no 858 0.238303097068795 1175 2980565
SGTC_3121 9125696 49.47 µM 0.711045298929985 0.257437745266878 no 859 0.238528082704762 1223 1235365
SGTC_2723 salbutamol 83.58 µM 0.710771201361867 0.257520066396383 no 860 0.238613014652944 1132 9884233 β2-adrenoceptor agonist
SGTC_430 0958-0115 16.4 µM 0.709721345356211 0.25783550147551 no 861 0.238938476374525 1101 6833180
SGTC_96 0929-0093 37.281 µM 0.70883852455166 0.258100905008084 no 862 0.239212343947227 1138 6991579
SGTC_1522 st012842 45.6 µM 0.707398099966512 0.258534245608124 no 863 0.239659558673623 1063 3491067 YOR116C RPO31
SGTC_3032 9089427 49.47 µM 0.705758347567771 0.259028010663808 no 864 0.240169214450525 1171 17173707
SGTC_2050 5263056 171 µM 0.704933916788113 0.25927644878529 no 865 0.240425680950994 1198 763468 YGL055W OLE1
SGTC_474 dl-dihydrosphingosine 5 µM 0.702550445855058 0.259995387894304 no 866 0.241167976811802 1227 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2406 ethylparaben 405.7 µM 0.702211174135793 0.260097807759491 no 867 0.241273739033337 1101 8434 A possible steroid mimic.
SGTC_3115 9123671 49.47 µM 0.701266748702187 0.260383021851703 no 868 0.241568280382764 1273 3286988
SGTC_2591 skatole 100 µM 0.700959674634678 0.26047579213762 no 869 0.241664090719449 1199 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1874 staurosporine 7.6 µM 0.699735007048216 0.260845946249646 no 870 0.242046404988491 1197 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2302 7771753 200 µM 0.698103935578421 0.261339355216616 no 871 0.242556098515514 1186 2203047
SGTC_2329 6138490 200 µM 0.695040347990008 0.262267403105479 no 872 0.243515008123437 1141 720019
SGTC_1854 st056233 32.9 µM 0.69491740462461 0.262304681352765 no 873 0.243553532355696 1145 5393174
SGTC_2806 7952793 58.44 µM 0.694600078494501 0.262400911871074 no 874 0.243652981525438 1197 2972490
SGTC_1408 3909-7976 48.8 µM 0.694384169605439 0.262466397506056 no 875 0.24372065933292 1236 24152374
SGTC_1567 st069303 68.4 µM 0.69383799426153 0.262632091018198 no 876 0.243891906242409 1233 5581319
SGTC_1280 0880-0253 10.1 µM 0.691011328267222 0.263490472705454 no 877 0.244779211030422 1194 6836607
SGTC_3267 9137951 49.47 µM 0.690363793583662 0.263687312791814 no 878 0.244982719813031 1199 16643986
SGTC_1004 4084-0029 199 µM 0.689690434039678 0.263892082744302 no 879 0.245194441407011 1210 716894 YLR208W SEC13
SGTC_72 0744-0168 198.391 µM 0.689519767305603 0.26394399570524 no 880 0.245248119050908 1136 677577
SGTC_1487 3970-0795 2.82 µM 0.68741475759636 0.264584719801386 no 881 0.245910700268222 1247 3765103
SGTC_2936 9038235 15.59 µM 0.686794347781529 0.264773711361898 no 882 0.246106166058145 1221 4749415
SGTC_1451 4152-0210 104 µM 0.684515375517348 0.265468529059092 no 883 0.24682489185419 1209 659563
SGTC_1417 3966-0327 90.4 µM 0.682653009293302 0.266037017158473 no 884 0.247413064686621 1262 651118
SGTC_340 k038-0059 454 µM 0.681845679387486 0.266283646409031 no 885 0.247668268312232 1207 23733424
SGTC_583 1488-1091 88.9 µM 0.681160162010701 0.266493154254553 no 886 0.247885076316425 1311 4303273
SGTC_2242 6630449 61.2675 µM 0.679344419602283 0.267048484110005 no 887 0.248459828812736 1199 691249 YDR170C SEC7
SGTC_2387 9077560 195.08 µM 0.679316064194013 0.267057161009696 no 888 0.248468810021306 1213 5303272
SGTC_2693 st077581 40.7 µM 0.677578693126072 0.267589076857562 no 889 0.249019429707032 1246 25238761
SGTC_1437 4092-1038 11.6 µM 0.677072583703687 0.267744128388682 no 890 0.24917995144083 1224 3977136
SGTC_3033 9090887 49.47 µM 0.676902159174418 0.267796349783304 no 891 0.249234017037946 1225 19325384
SGTC_1271 0832-2808 169 µM 0.675457528135143 0.268239218871924 no 892 0.249692563242961 1242 3663794
SGTC_2834 9001755 58.44 µM 0.673961941237521 0.268698096982826 no 893 0.250167755172889 1164 2989575
SGTC_960 1222-0186 7.7 µM 0.668850792123735 0.270269278260347 no 894 0.251795331298868 1233 3126296
SGTC_1219 1469-0211 33.1 µM 0.664534524638016 0.271599678805964 no 895 0.253174129851665 1217 6822282
SGTC_3241 9133421 49.47 µM 0.663808160547829 0.271823885714915 no 896 0.253406551008958 1256 17018221
SGTC_2956 9076196 2.52 µM 0.663381868772639 0.271955512130771 no 897 0.253543007568781 1285 16423868
SGTC_916 4466-0038 42 nM 0.661930083425979 0.272404018621978 no 898 0.25400801542372 1299 5722064 YGL116W CDC20
SGTC_309 k408-0051 1.48 µM 0.661142272313303 0.272647554285957 no 899 0.254260539034235 1235 3640463
SGTC_195 4234-0266 16.654 µM 0.659571423379786 0.273133472368983 no 900 0.254764448842275 1245 2303354
SGTC_479 n-linoleoylglycine 10 µM 0.659108862257992 0.273276640323706 no 901 0.254912932581673 1250 6433346 An anti-infammatory.
SGTC_651 3253-0966 34.4 µM 0.658473037129547 0.27347349611509 no 902 0.255117108561833 1276 781462
SGTC_1127 asiatic acid 681.4 nM 0.658095401822295 0.273590447797302 no 903 0.255238415175889 1239 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1616 st002734 56.1 µM 0.656544368730769 0.27407105406966 no 904 0.255736964830573 1233 4026101
SGTC_769 0302-0231 76 µM 0.655225675589996 0.274479994844865 no 905 0.256161232827869 1264 571869 YER009W NTF2
SGTC_2789 5281112 71.43 µM 0.652670035890715 0.275273382129127 no 906 0.256984511916773 1261 765948
SGTC_1449 4112-4002 201 µM 0.652067981708172 0.275460451396694 no 907 0.25717865904058 1223 2059539
SGTC_3329 9141233 27.5565 µM 0.651005855932525 0.27579062574618 no 908 0.257521353372428 1263 4909101 YNL103W MET4
SGTC_2968 9090663 33.37 µM 0.650211941856337 0.27603755026854 no 909 0.257777664159712 1238 25236811
SGTC_3106 9121286 49.47 µM 0.650082186767433 0.276077917238198 no 910 0.257819567460681 1289 15943471
SGTC_1454 4239-0054 42.6 µM 0.648932316382419 0.27643576993852 no 911 0.258191062721182 1365 1340767
SGTC_2740 felodipine 17.08 µM 0.648617265495594 0.276533857032281 no 912 0.258292896439552 1231 3333 L-type calcium channel blocker
SGTC_864 0469-0573 172 µM 0.648489147185964 0.276573749921053 no 913 0.258334314000429 1229 689425
SGTC_2020 4017018 200 µM 0.647621023465607 0.276844136579224 no 914 0.258615048109764 1280 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1269 0831-0796 3.05 µM 0.645897782268283 0.277381242212946 no 915 0.259172777982312 1261 927758
SGTC_1460 k062-0059 9.15 µM 0.644581636766776 0.277791805751341 no 916 0.25959916906198 1245 1373085
SGTC_775 4577-0580 57.3 µM 0.644102588299139 0.277941315611461 no 917 0.259754456037421 1337 2006902
SGTC_3119 9125183 49.47 µM 0.64278260492243 0.278353482282114 no 918 0.260182585939382 1145 22695334
SGTC_1391 3442-0225 151 µM 0.639333290920198 0.27943193969591 no 919 0.261303067883304 1261 5227075
SGTC_1663 st014140 55.4 µM 0.639174905916959 0.279481508808973 no 920 0.26135457744031 1352 4207120
SGTC_1380 2291-0730 164 µM 0.638799081272715 0.279599146210701 no 921 0.261476823016025 1276 2999191
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.636990948075871 0.28016544829296 no 922 0.262065369888085 1325 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1935 st074532 41.6 µM 0.636172883026193 0.28042184637726 no 923 0.262331872765042 1342 2829742
SGTC_1251 0490-5699 265 µM 0.635883141703171 0.280512684385989 no 924 0.262426295717477 1323 3883818
SGTC_1820 st053765 18.6 µM 0.63543631203158 0.280652799727712 no 925 0.262571945835213 1253 3690829
SGTC_3207 9114163 49.47 µM 0.632944581767354 0.281434768332252 no 926 0.263384916628305 1362 849233
SGTC_213 1246-0773 967 nM 0.631910574607741 0.281759574565177 no 927 0.263722656537037 1289 6251622
SGTC_86 0417-1630 471.922 µM 0.629971892055204 0.282369047382049 no 928 0.264356487232749 1318 3634867
SGTC_624 k048-0052 28 µM 0.629199955285058 0.282611901210936 no 929 0.264609079065556 1273 6835531
SGTC_1515 3460-0031 42.1 µM 0.626083086618527 0.283593498024619 no 930 0.265630222636619 1262 2876596
SGTC_1800 st050079 29.0735 µM 0.625948772032941 0.28363583446106 no 931 0.265674271440422 1272 3645560
SGTC_43 0570-0105 72.5 µM 0.624643761964716 0.2840473358246 no 932 0.266102445480088 1344 1114046 YDL195W SEC31
SGTC_1281 0884-0031 11.8 µM 0.624379515232533 0.28413069399257 no 933 0.266189187405003 1307 1548255
SGTC_61 0978-8327 98.565 µM 0.624100118557954 0.284218844020564 no 934 0.266280918033863 1319 6150059 YHR072W ERG7
SGTC_126 0417-1624 672.48 µM 0.623772485147073 0.284322229457293 no 935 0.2663885059721 1377 41912 YDL195W SEC31
SGTC_64 000l-0018 272.079 µM 0.622481876724921 0.284729658515331 no 936 0.266812528554324 1281 6811119
SGTC_549 1661-1316 519 µM 0.621192296381255 0.285137041143033 no 937 0.26723655374805 1335 2857282
SGTC_2776 terbinafine 19.92 µM 0.615684220879672 0.286880180383589 no 938 0.269051476733728 1312 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_901 1112-0062 60.1 µM 0.615277448185202 0.287009111601189 no 939 0.269185754115394 1328 1908457
SGTC_399 oxolinic acid 75 µM 0.613513340320439 0.287568582963955 no 940 0.269768482344517 1289 4628 A DNA gyrase inhibitor.
SGTC_2447 5741742 33.78 µM 0.612994872569436 0.287733108446172 no 941 0.2699398650311 1384 1776504
SGTC_1743 st037606 46.3785 µM 0.612336078352516 0.287942227892268 no 942 0.270157712075023 1354 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_482 fipronil 114 µM 0.612283493211549 0.287958922957705 no 943 0.270175104476577 1341 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_387 norethindrone acetate 66.7 µM 0.611974032594028 0.288057181742506 no 944 0.270277469132053 1322 541197
SGTC_454 lyso-paf C-16 6.67 µM 0.611061863710881 0.2883469022418 no 945 0.27057931288117 1246 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_877 0771-0151 33.1 µM 0.610594150323274 0.288495509309198 no 946 0.270734148142668 1368 6166523
SGTC_459 nigericin 15.3 µM 0.608176908772509 0.289264116719826 no 947 0.271535073908492 1371 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2488 5268135 45.7 µM 0.606823614307677 0.289694841975786 no 948 0.271983987479807 1371 1270356 YLR208W SEC13
SGTC_892 0929-0076 29 µM 0.606679513980947 0.28974072381518 no 949 0.272031810040364 1307 5751038
SGTC_666 0272-0154 136 µM 0.606560987442698 0.289778465463571 no 950 0.272071148564204 1343 6870312
SGTC_2170 morpholine 200 µM 0.605593749977972 0.290086542891343 no 951 0.27239227681788 1387 121171 Reacts with secondary amines.
SGTC_593 1203-0218 61.7 µM 0.604917925821941 0.290301892536959 no 952 0.27261676589642 1372 3666956
SGTC_225 nsc-122657 1.016 µM 0.604818399434951 0.290333612690547 no 953 0.272649833416175 1312 275685
SGTC_3262 9137218 49.47 µM 0.60365460440238 0.290704647356553 no 954 0.273036650558057 1218 17650664
SGTC_640 3381-0960 37.1 µM 0.601274298512613 0.291464213083071 no 955 0.273828652538436 1399 1745025
SGTC_2616 abietic acid 100 µM 0.600318660472021 0.291769421466904 no 956 0.274146942393114 1349 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2028 5153890 36.43 µM 0.599476308669323 0.292038572306178 no 957 0.274427651996985 1308 2830968 YPR165W RHO1
SGTC_945 3381-0768 11.3 µM 0.598249257099254 0.29243085028163 no 958 0.274836814577087 1339 1126236 YIL048W NEO1
SGTC_3123 9126162 49.47 µM 0.596278791918889 0.293061303292793 no 959 0.275494498286687 1394 25239884
SGTC_936 3005-4620 401 µM 0.596128155571896 0.293109525527054 no 960 0.275544808132979 1436 777207
SGTC_1807 st050092 58.9 µM 0.59480302507836 0.293533889422807 no 961 0.275987572623334 1318 5008496
SGTC_1895 st058434 18.3 µM 0.593186886356488 0.294051831456956 no 962 0.276528043887721 1360 5393175
SGTC_349 k015-0014 24 µM 0.592867437219982 0.294154258874008 no 963 0.276634935881497 1321 2196908
SGTC_345 1362-0200 395 µM 0.592781345204188 0.29418186603473 no 964 0.276663746896014 1326 1419823
SGTC_2946 9065502 71.43 µM 0.592703470995252 0.294206839019213 no 965 0.27668980905733 1219 16489101
SGTC_1395 3486-0190 4.35 µM 0.590758609426342 0.29483084171052 no 966 0.277341085785215 1416 6748079
SGTC_2110 5483698 200 µM 0.590320784576396 0.294971400517466 no 967 0.277487803706303 1352 2848765 YHR062C RPP1
SGTC_2790 5423970 71.43 µM 0.586735891818828 0.296123450104848 no 968 0.278690549222649 1428 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1968 st069590 43.6 µM 0.586221162826382 0.296289033988626 no 969 0.278863450963632 1318 6384066
SGTC_2480 5767542 37.17 µM 0.580322705134338 0.298189540503925 no 970 0.28084850938365 1386 2867358
SGTC_3014 9081533 49.47 µM 0.577969012119659 0.298949456496762 no 971 0.281642520308053 1418 21367265
SGTC_51 1013-0126 23.419 µM 0.574752888548282 0.2999892374195 no 972 0.282729216395807 1490 1627850
SGTC_226 1,3-diallylurea 8.28947 mM 0.573436469134514 0.300415310638085 no 973 0.283174601732593 1349 74537 YKL182W FAS1
SGTC_1725 st036284 20.55 µM 0.572150050995247 0.300831937541469 no 974 0.283610161645796 1479 707914
SGTC_2745 rifampicin 24.3 µM 0.571938843292787 0.300900365404964 no 975 0.28368170374396 1379 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2362 9071156 126 µM 0.57138161508474 0.301080931969158 no 976 0.283870494372315 1442 653133
SGTC_2167 5876490 200 µM 0.571219986881056 0.301133315784821 no 977 0.283925265753811 1559 686534
SGTC_2347 9049783 174.81 µM 0.570247481471797 0.301448592133305 no 978 0.284254927982305 1424 6467988 YPL169C MEX67
SGTC_1051 3253-3903 78 µM 0.569561939814847 0.301670926988229 no 979 0.284487424449449 1353 5509239
SGTC_1697 st025554 27.742 µM 0.567254194016393 0.302419916402214 no 980 0.285270746514686 1363 1269519
SGTC_2552 juarezic acid 87.02 µM 0.566336517959911 0.302717983912744 no 981 0.285582520152257 1412 1549512
SGTC_2561 acetosyringone 100 µM 0.565518990408729 0.302983633282699 no 982 0.285860405591678 1359 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2692 st077426 47.7 µM 0.563056951116392 0.303784283664922 no 983 0.286698052033075 1392 25238571
SGTC_922 1866-0035 480 µM 0.559966924038973 0.304790488007704 no 984 0.28775099937071 1452 3156169
SGTC_514 4466-0038 2.65 nM 0.5590765253491 0.305080702895122 no 985 0.288054747395678 1370 5722064
SGTC_1263 0774-1208 64.8 µM 0.558126697042601 0.305390423337144 no 986 0.288378935786244 1478 906585
SGTC_2640 pentamidine 10.38 µM 0.557983348732365 0.305437178526887 no 987 0.288427877308717 1429 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1512 0259-0544 12.2 µM 0.556343659106923 0.3059722133799 no 988 0.288987973228632 1395 18476
SGTC_3279 9140807 49.47 µM 0.55542402251735 0.306272474527797 no 989 0.289302332529145 1408 45595718
SGTC_298 1391-0729 10 µM 0.55517894373806 0.306352514669825 no 990 0.289386134900381 1381 3237558
SGTC_2442 5158906 48.48 µM 0.554766371493528 0.306487277281065 no 991 0.289527235832544 1496 1893835
SGTC_279 1273-0055 2.93 µM 0.552900345852211 0.307097122655017 no 992 0.29016582530466 1449 2847562
SGTC_3310 9130229 44.1445 µM 0.551705371583835 0.307487938904475 no 993 0.290575114560458 1459 7761258
SGTC_3330 9141424 71.43 µM 0.551545782129104 0.307540149183215 no 994 0.290629795800363 1465 27261020
SGTC_902 1120-0002 2.07 µM 0.549374759958511 0.308250794045429 no 995 0.291374145876715 1366 3280475
SGTC_2756 carbadox 75.1 µM 0.549286323429644 0.308279757408649 no 996 0.291404485803213 1396 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3120 9124077 49.47 µM 0.546287962789017 0.309262439371478 no 997 0.292434004608467 1426 18774327 YGL155W CDC43
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.545661347835956 0.309467978793172 no 998 0.292649372897569 1484 688761
SGTC_1222 0366-0074 1.18 µM 0.544291999761056 0.309917353627865 no 999 0.29312027568293 1476 286520
SGTC_971 1315-0384 26.7 µM 0.543795330101258 0.310080414470455 no 1000 0.293291161370903 1408 6769120
SGTC_1402 3909-7673 35.9 µM 0.543565704972364 0.310155814968908 no 1001 0.293370182503469 1393 5328014
SGTC_1 0258-0098 57.368 µM 0.541149275911343 0.310949765441273 no 1002 0.294202348225496 1379 6790032 YDR047W HEM12
SGTC_1499 4480-0877 67.3 µM 0.541118101166223 0.310960014088285 no 1003 0.294213091253088 1396 2861909
SGTC_656 4090-1979 187 µM 0.540603248863221 0.311129292150861 no 1004 0.294390539037505 1487 22330961
SGTC_159 3970-0959 50 µM 0.540581290397662 0.311136512753832 no 1005 0.294398108289158 1487 6615653
SGTC_598 3937-0236 20.2 µM 0.54009966670328 0.311294903366755 no 1006 0.294564150267116 1461 1379313
SGTC_1021 4476-0760 85.3 µM 0.540055003051518 0.311309593582732 no 1007 0.294579550455069 1391 746768
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.539504931127609 0.311490541071372 no 1008 0.294769247688296 1397 23665772 A membrane-active detergent.
SGTC_2695 st077686 51.995 µM 0.539262242544932 0.311570388548602 no 1009 0.294852958924049 1384 2876092
SGTC_317 4495-0002 170 µM 0.538875593968925 0.311697618909059 no 1010 0.294986349304618 1390 15991618
SGTC_1671 st016596 74.5 µM 0.538453714749971 0.311836467892111 no 1011 0.295131925658609 1425 2829167
SGTC_170 4197-0004 226 µM 0.538382853330277 0.311859792442672 no 1012 0.295156380800027 1455 218692
SGTC_1770 st043884 66.3 µM 0.537764501571816 0.31206335942503 no 1013 0.295369821127775 1425 670149
SGTC_2263 7948595 193.29 µM 0.536596822976308 0.312447926281503 no 1014 0.295773069566335 1421 2971371
SGTC_2425 5628681 7.85 µM 0.53551460401907 0.312804530085459 no 1015 0.296147030886632 1471 5714958
SGTC_1819 st053448 58.6 µM 0.535508454686254 0.312806556863599 no 1016 0.296149156411479 1443 2857616
SGTC_804 1595-0054 20.9 µM 0.534346136947632 0.313189750426058 no 1017 0.296551038672181 1403 761523 Stimulates phospholipase C.
SGTC_2904 7225135 42.03 µM 0.53373040962538 0.313392825555997 no 1018 0.296764033359596 1485 4446116
SGTC_1789 tunicamycin 25 nM 0.533444247377475 0.313487224968454 no 1019 0.296863047502359 1406 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_951 1171-0579 82.7 µM 0.532892128511616 0.31366939286846 no 1020 0.297054127210133 1367 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2262 9014885 67.46 µM 0.532743287785963 0.313718509641565 no 1021 0.297105648282179 1413 6457424
SGTC_2433 5607874 27.82 µM 0.53250465089503 0.313797265637901 no 1022 0.297188260735073 1399 2252428
SGTC_2222 6885208 172.143 µM 0.529535688172154 0.314777804291557 no 1023 0.298216947119244 1414 609514
SGTC_2639 lactacystin 53 µM 0.529106401260602 0.314919690232839 no 1024 0.298365820561467 1493 3870 A proteasome inhibitor.
SGTC_2809 7964133 12.99 µM 0.52824179434946 0.315205539051562 no 1025 0.298665762302478 1470 1253665
SGTC_98 0074-0023 107.663 µM 0.528239087160226 0.315206434252824 no 1026 0.298666701671764 1380 3563821
SGTC_447 ml7 120 µM 0.528022762623096 0.31527797099327 no 1027 0.298741768600238 1525 4216 Selective myosin light chain kinase inhibitor.
SGTC_1788 fluconazole 20 µM 0.527227560888125 0.315540997160717 no 1028 0.299017785785514 1428 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2414 st077232 92.9 µM 0.52471387508594 0.316373054743052 no 1029 0.299891055168974 1396 729801
SGTC_973 1325-0077 65.9 µM 0.524611660808218 0.316406908504758 no 1030 0.299926589429922 1552 2835149
SGTC_162 k030-0015 37.8 µM 0.52181551183669 0.317333599705016 no 1031 0.300899394170101 1557 1809920 YMR134W ERG29
SGTC_1864 st057645 30.4 µM 0.521775861286538 0.317346748825588 no 1032 0.30091319917114 1466 688666
SGTC_1989 st071868 50.2 µM 0.521748084036645 0.31735596059822 no 1033 0.300922870454587 1530 16414057
SGTC_2524 avocatin b 10.57 µM 0.521208843953326 0.317534811260303 no 1034 0.301110646960836 1468 6710748
SGTC_1074 carmofur 3.8 µM 0.519529831459929 0.318091964817534 no 1035 0.301695657788187 1468 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1783 st039459 87.517 µM 0.519081826094647 0.318240697932274 no 1036 0.30185184063209 1592 729761
SGTC_1348 1493-0373 93.8 µM 0.518836309799684 0.318322219218544 no 1037 0.301937447501281 1475 3010129
SGTC_876 0720-0963 56.8 µM 0.518064096582668 0.31857868241653 no 1038 0.302206774659388 1570 765861
SGTC_1314 1222-0010 41.1 µM 0.51718135906516 0.318871958831373 no 1039 0.302514781715785 1456 3526027
SGTC_818 4072-2707 53.5 µM 0.5160455092878 0.31924949493298 no 1040 0.302911312254766 1405 882871
SGTC_1245 0418-0076 17.2 µM 0.51527457866213 0.31950584530411 no 1041 0.303180580263331 1491 6790114
SGTC_2058 5236698 133 µM 0.513401373501095 0.320129084076672 no 1042 0.303835292506011 1477 766665
SGTC_77 0828-0286 12.516 µM 0.509342930286467 0.321481119271358 no 1043 0.305255935634563 1417 745345
SGTC_1403 3909-7815 62.9 µM 0.508542835668417 0.321747943912484 no 1044 0.30553635325995 1505 6615483
SGTC_1681 tripelennamine 100 µM 0.506007859427203 0.322593943294132 no 1045 0.306425566144922 1431 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1278 0874-0585 172 µM 0.501901100247465 0.323966444603046 no 1046 0.30786854565532 1497 766306
SGTC_789 1309-1135 70.6 µM 0.500117644687191 0.324563232707476 no 1047 0.308496121328991 1443 3092424
SGTC_484 loperamide 105 µM 0.499661102000373 0.32471607564589 no 1048 0.308656863068091 1483 3955 An opioid-receptor agonist.
SGTC_2125 5246583 200 µM 0.499640314761162 0.324723035572481 no 1049 0.308664182812061 1595 835267
SGTC_194 1486-1323 56.904 µM 0.499126413817459 0.324895117933484 no 1050 0.30884516527136 1449 5178754
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.498939184814353 0.324957821812853 no 1051 0.308911113965715 1456 75037 A free radical scavenger.
SGTC_3082 9117008 49.47 µM 0.498437142715216 0.325125982560079 no 1052 0.309087981400432 1480 41448529
SGTC_481 bay k-8644 50 µM 0.498181766936517 0.325211535237274 no 1053 0.309177966258343 1437 2303 A calcium channel antagonist.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.497903427391034 0.325304791431735 no 1054 0.309276055726748 1414 4000243
SGTC_2196 6573537 42.6665 µM 0.497253707163311 0.325522519330929 no 1055 0.309505076128362 1567 2903087
SGTC_173 1273-0061 2.693 µM 0.496831450806292 0.325664053691013 no 1056 0.309653957289167 1412 2847414 YPL266W DIM1
SGTC_1188 1403-0014 4.57 µM 0.496514603182836 0.325770273042203 no 1057 0.309765693450623 1484 9614867
SGTC_3190 9110366 49.47 µM 0.495630721174349 0.326066658591607 no 1058 0.310077486909663 1560 17123768
SGTC_2385 9074692 200 µM 0.495619502661919 0.326070421118318 no 1059 0.31008144517012 1445 17046906
SGTC_1246 0422-0085 105 µM 0.495589022404237 0.326080643845035 no 1060 0.310092199719457 1537 264295
SGTC_3316 9136639 10.545 µM 0.493757723118839 0.326695080094937 no 1061 0.310738646887123 1550 4903665
SGTC_3065 9113888 49.47 µM 0.49143450179355 0.327475242405658 no 1062 0.311559583447522 1538 16648368
SGTC_497 capsazepine 133 µM 0.491387893909383 0.327490901552701 no 1063 0.311576062478107 1417 2733484 A calcium channel blocker.
SGTC_2474 5321570 43.32 µM 0.491181905714959 0.327560112349922 no 1064 0.311648897717639 1563 2841384
SGTC_884 0851-0618 334 µM 0.488387946764693 0.328499450268143 no 1065 0.312637538873232 1563 9642473
SGTC_1636 st007707 68.9 µM 0.487224249603198 0.328891009375415 no 1066 0.313049711167947 1588 403051
SGTC_2397 5161689 200 µM 0.487145966604249 0.328917356672363 no 1067 0.313077446780916 1577 2259942
SGTC_2350 9023895 38.85 µM 0.487111248540981 0.328929041820317 no 1068 0.313089747705554 1568 2997209
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.485064110275713 0.329618347673043 no 1069 0.313815434744535 1502 140250 A respiratory chain inhibitor.
SGTC_633 0437-0093 97.7 µM 0.482801421923202 0.330380906795586 no 1070 0.314618370547467 1507 2831118
SGTC_2567 aureobasidin a 60 nM 0.482213213733245 0.330579257140383 no 1071 0.314827245497906 1590 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_297 0986-0032 24 µM 0.481487314647076 0.330824103993189 no 1072 0.315085096683062 1479 2847425
SGTC_1017 4239-0030 168 µM 0.480691008834922 0.331092782406127 no 1073 0.315368061156413 1439 1149593
SGTC_1049 3226-0134 66 µM 0.48045372683215 0.331172859623769 no 1074 0.315452399438864 1522 5702385
SGTC_2372 9071633 200 µM 0.478036458969685 0.331989071390703 no 1075 0.316312127858824 1542 21321366
SGTC_172 1112-0046 2.638 µM 0.476843289146611 0.332392250062773 no 1076 0.316736858747774 1529 2802135 YIL048W NEO1
SGTC_2914 7968218 45.32 µM 0.47592003034141 0.332704357489525 no 1077 0.317065675722233 1576 2977111
SGTC_2667 digitoxin 100 µM 0.474312726801374 0.333247982698487 no 1078 0.317638458661787 1537 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_274 sirtinol 40.1 µM 0.473901562199603 0.333387103903895 no 1079 0.317785052578731 1471 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1809 st050081 57.6 µM 0.473306003269986 0.333588657215693 no 1080 0.317997439885358 1585 5036894
SGTC_2461 5755302 26.15 µM 0.473114663808046 0.333653421883947 no 1081 0.318065687780549 1625 2788904
SGTC_2281 7943571 200 µM 0.472611988763265 0.3338235911763 no 1082 0.318245013806477 1596 1244024
SGTC_1664 st014217 9.02 µM 0.472387568420326 0.333899574657971 no 1083 0.318325088051664 1571 3982782
SGTC_2769 toremifene 3.73 µM 0.471688643254956 0.334136258002278 no 1084 0.318574522248742 1552 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2124 5246320 200 µM 0.470560484190194 0.334518435862175 no 1085 0.318977316015217 1551 579342
SGTC_1342 1486-1464 234 µM 0.470304632616729 0.334605132629584 no 1086 0.319068694088738 1510 3253938
SGTC_3 0833-0587 95.581 µM 0.470236878857003 0.334628092855331 no 1087 0.319092894366893 1497 5382644
SGTC_296 1222-0039 74.9 µM 0.466703927592326 0.335826185688517 no 1088 0.320355859675422 1473 5984176
SGTC_294 k038-0071 157 µM 0.464177813184062 0.336683865531185 no 1089 0.321260177840279 1549 24152826
SGTC_3079 9117512 49.47 µM 0.464032095830533 0.336733366241862 no 1090 0.321312375286584 1596 7185044
SGTC_558 k064-0027 21.3 µM 0.46395484413517 0.33675961006884 no 1091 0.321340049065587 1599 5088526
SGTC_2991 9074669 71.4286 µM 0.463659086861397 0.336860091620735 no 1092 0.321446006993644 1623 17333109
SGTC_3138 9097216 49.47 µM 0.46142260012416 0.337620299533306 no 1093 0.322247720066821 1511 25237486
SGTC_738 1315-0003 72.4 µM 0.461387806453468 0.337632131553474 no 1094 0.322260199096122 1605 6251474
SGTC_1939 st074455 53.6 µM 0.459837203019263 0.338159596331772 no 1095 0.322816538693612 1658 1644229
SGTC_1496 4469-0713 57.4 µM 0.459059454225538 0.338424280892554 no 1096 0.323095735979099 1613 746691
SGTC_785 1270-0111 65.3 µM 0.458659699895957 0.338560356923752 no 1097 0.323239279114934 1505 6741994
SGTC_643 k048-0106 28.4 µM 0.457172110169638 0.339066916247733 no 1098 0.323773671494165 1598 6763920
SGTC_1591 genipin 88.4 µM 0.457035837367245 0.339113334912704 no 1099 0.323822643470419 1596 442424 A DNA cross-linking agent.
SGTC_2090 5301565 104.445 µM 0.456978690993421 0.339132801434185 no 1100 0.323843180910894 1551 2056344
SGTC_2114 5491910 81.25 µM 0.456831525909904 0.339182934190465 no 1101 0.323896072022427 1620 2849228
SGTC_535 2293-4129 48.2 µM 0.455719991340165 0.33956167768492 no 1102 0.324295672194297 1647 396118 YIL048W NEO1
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.4555748212412 0.33961115481525 no 1103 0.324347876257858 1581 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1550 gossypolone 36.6 µM 0.454877775283842 0.339848761739936 no 1104 0.324598586360972 1535 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1058 3448-5425 97.3 µM 0.453236804853727 0.3404083819243 no 1105 0.325189116360466 1495 7279705
SGTC_2848 9016370 25.97 µM 0.452032327038289 0.340819368863023 no 1106 0.325622847044336 1649 7894410
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.451583689880328 0.34097249931687 no 1107 0.325784461027442 1509 2374 Ca(2+)-ATPase inhibitor.
SGTC_1464 k208-0027 110 µM 0.447936939893813 0.342218191342075 no 1108 0.327099353918481 1641 X1464
SGTC_3276 9139060 49.47 µM 0.447662479211582 0.342312013985716 no 1109 0.327198402176976 1590 4870619
SGTC_1379 2144-0755 36.5 µM 0.447303587806112 0.342434713421374 no 1110 0.327327938429064 1630 5392327
SGTC_827 3253-0474 693 µM 0.445991509026499 0.342883434381609 no 1111 0.327801689684438 1671 5402065
SGTC_1679 SEC14.276 6.7 µM 0.445313077409699 0.343115539836254 no 1112 0.328046759261086 1686 1005053 YMR079W SEC14
SGTC_1839 st053978 48 µM 0.444770496546588 0.343301210558126 no 1113 0.328242808822497 1584 3788398
SGTC_1226 3909-7979 35.4 µM 0.443975125175957 0.343573454342965 no 1114 0.32853028413488 1655 6615510
SGTC_3179 9107801 49.47 µM 0.443952631092302 0.343581154913853 no 1115 0.328538415768415 1526 4818259
SGTC_2853 9015042 58.44 µM 0.443038646893306 0.343894100956123 no 1116 0.328868890609133 1472 6457456
SGTC_2449 5812982 45.77 µM 0.441920324829706 0.344277157318478 no 1117 0.329273431192273 1554 776185
SGTC_718 1130-0073 349 µM 0.439311938188482 0.345171222677633 no 1118 0.330217762545881 1636 6740020
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.439144462418351 0.34522865721992 no 1119 0.33027843194542 1612 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2241 6772625 37.8075 µM 0.438727865753112 0.345371541339753 no 1120 0.330429366677724 1515 2285411
SGTC_1080 nisoldipine 24.4 µM 0.436946059114394 0.345982913007433 no 1121 0.33107523383979 1565 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2684 capsaicin 100 µM 0.435780490883038 0.346383059040312 no 1122 0.331497999895561 1567 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.43514867874278 0.346600035362461 no 1123 0.331727255797311 1648 6710655
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.433589093945475 0.347135841829498 no 1124 0.332293427916286 1511 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2902 5787006 60.46 µM 0.432840797971376 0.347393032844744 no 1125 0.332565215940616 1547 591003
SGTC_1822 st052468 42 µM 0.430652691719549 0.348145492742598 no 1126 0.333360461066977 1550 2873678
SGTC_1122 capsaicin 818.572 nM 0.430552581283536 0.348179933689322 no 1127 0.333396863153241 1663 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_386 1509-0011 3.07 µM 0.429843971402447 0.348423752201433 no 1128 0.333654572221982 1577 3107280
SGTC_3171 9103192 49.47 µM 0.429582388759398 0.348513773402049 no 1129 0.333749725117473 1634 13018434
SGTC_2624 nerol 100 µM 0.428493608513168 0.34888855847347 no 1130 0.334145892946771 1670 637566 A natural product oil.
SGTC_3125 9127534 49.47 µM 0.428159973741776 0.349003433345441 no 1131 0.334267327618733 1553 1639235
SGTC_2346 9031566 143.75 µM 0.425422881880426 0.349946371984538 no 1132 0.335264214217807 1685 4771086
SGTC_589 1227-0070 34.1 µM 0.424827951126827 0.350151450635665 no 1133 0.335481050078091 1596 2841384
SGTC_812 4251-0442 148 µM 0.424479492157506 0.350271588269237 no 1134 0.33560807922447 1607 5723007
SGTC_3306 9127676 59.7925 µM 0.420367136630236 0.351690527325335 no 1135 0.337108635882988 1575 41905287
SGTC_1677 st019204 53.9 µM 0.417689882594411 0.352615407927239 no 1136 0.338086935235271 1529 3945625
SGTC_1687 st020778 55.3625 µM 0.417541756654662 0.352666604820709 no 1137 0.338141094163303 1625 4259299
SGTC_937 3122-0005 46.7 µM 0.417323700418385 0.352741976637138 no 1138 0.338220827630941 1715 759535
SGTC_1808 st050063 61.5 µM 0.416839557797337 0.352909342701209 no 1139 0.33839788299075 1670 4011993
SGTC_1034 k072-0165 12.7 µM 0.415083755881364 0.353516554629099 no 1140 0.339040295268206 1730 5835461
SGTC_888 0916-0002 6.97 µM 0.414695042261954 0.353651034593211 no 1141 0.339182581070983 1683 2802138 YIL048W NEO1
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.414659794539345 0.353663229853297 no 1142 0.339195484378903 1578 91467 include heat shock
SGTC_167 3672-0051 66.205 µM 0.414319558047037 0.353780955037344 no 1143 0.339320046126595 1539 3237971
SGTC_1444 4112-3581 28 µM 0.413902899979084 0.353925141887579 no 1144 0.33947260999389 1621 2877249
SGTC_1327 1436-0082 2.18 µM 0.413038902824664 0.354224199675791 no 1145 0.339789055744608 1613 15992205
SGTC_3192 9110362 49.47 µM 0.412050780488946 0.354566331491484 no 1146 0.340151101761237 1637 16649480
SGTC_708 3448-5400 146 µM 0.411423378058677 0.354783627002369 no 1147 0.340381057284075 1595 3462195
SGTC_3336 9143619 71.43 µM 0.411165528206516 0.354872944817133 no 1148 0.340475581622239 1657 45595730
SGTC_1261 0712-0010 12.7 µM 0.408119247320844 0.355928762914886 no 1149 0.341593064993302 1731 2840123
SGTC_1157 4092-0394 27.6 µM 0.407830237898009 0.356028988975459 no 1150 0.341699156189014 1687 3659885
SGTC_2681 menadione 3.18 µM 0.407056374734516 0.356297407247155 no 1151 0.341983291760505 1617 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2458 5808907 16.39 µM 0.406422006613697 0.35651749409563 no 1152 0.342216276390645 1682 2731747
SGTC_3344 9148862 3.898 µM 0.405856162565138 0.356713847619248 no 1153 0.342424144852618 1690 4905352
SGTC_2399 5884133 200 µM 0.405662444730644 0.356781078366697 no 1154 0.342495320006714 1566 722445
SGTC_518 1021-0119 62.6 µM 0.404412001606577 0.357215157899284 no 1155 0.342954888091824 1556 1097762
SGTC_1290 0986-0249 10.2 µM 0.403938806402558 0.357379471393565 no 1156 0.34312885943256 1627 53329
SGTC_1707 st032323 6.317 µM 0.403689623765395 0.357466008831836 no 1157 0.343220485390454 1630 3132057 YMR211W DML1
SGTC_1043 0916-0009 19.3 µM 0.403668023976997 0.357473510463618 no 1158 0.343228428197052 1803 3101130
SGTC_580 1123-0028 41 µM 0.403078496008666 0.357678275471178 no 1159 0.343445239764654 1648 1677248 YPR107C YTH1
SGTC_1178 0988-0033 191 µM 0.401624186876693 0.358183586254172 no 1160 0.343980313379574 1668 5392207
SGTC_3149 9097855 49.47 µM 0.400328474459153 0.358634000775403 no 1161 0.34445729900328 1760 25236625 YMR079W SEC14
SGTC_796 1234-0020 70.7 µM 0.399296723329803 0.358992797990851 no 1162 0.344837290598884 1567 46495034
SGTC_1032 k061-1018 98.7 µM 0.399009270519973 0.359092783486743 no 1163 0.34494318671887 1788 4005393
SGTC_156 3474-0145 5.642 µM 0.398963285724395 0.359108779399551 no 1164 0.344960128405558 1771 2265471
SGTC_1019 4262-0212 3.4 µM 0.398730887056244 0.359189623568089 no 1165 0.345045753316788 1683 4677213
SGTC_2219 9098279 200 µM 0.397353032752149 0.359669065036695 no 1166 0.345553572484589 1727 902349
SGTC_1109 tnp00067 928.257 nM 0.397283305589976 0.35969333334586 no 1167 0.345579278384804 1621 676295
SGTC_1315 1237-0019 3.69 µM 0.396934665217005 0.359814684964485 no 1168 0.345707820247417 1701 825140
SGTC_540 1187-0821 17.3 µM 0.396066428566667 0.360116954403396 no 1169 0.34602801179875 1583 847520
SGTC_3326 9140064 16.379 µM 0.395370059883242 0.360359452653499 no 1170 0.346284900834204 1567 1868434
SGTC_1745 st081495 74 µM 0.39486750369296 0.360534493994033 no 1171 0.346470336774522 1664 13842402 YBL026W LSM2
SGTC_102 gallobenzophenone 83.616 µM 0.394552168260131 0.360644340891524 no 1172 0.346586709765764 1737 70837
SGTC_379 3970-0972 5.9 µM 0.392583388514485 0.361330423773273 no 1173 0.347313605278685 1667 2898042 YBL034C STU1
SGTC_1103 duloxetine 36.1 µM 0.391141397987025 0.361833213714902 no 1174 0.347846361034363 1749 60835 A selective serotonin reuptake inhibitor.
SGTC_999 SEC7.066 22.7 µM 0.390927221802615 0.361907912545351 no 1175 0.347925515920524 1694 740511 YDR170C SEC7
SGTC_1900 st060200 72.8 µM 0.390746765194523 0.361970854988325 no 1176 0.347992213925255 1617 688945
SGTC_2243 6634756 200 µM 0.39069625041596 0.361988474981892 no 1177 0.348010885377821 1737 885676
SGTC_1350 1495-0454 146 µM 0.390626452960807 0.362012821421864 no 1178 0.348036684768402 1712 1069057
SGTC_2933 9026794 32.47 µM 0.390493617532327 0.362059158031677 no 1179 0.348085786970242 1699 17586027
SGTC_1799 st045822 46.1415 µM 0.390128840516229 0.362186412571985 no 1180 0.348220638755244 1752 3674992
SGTC_190 3970-0790 3.722 µM 0.390115864445279 0.362190939628925 no 1181 0.348225436138945 1720 2832352
SGTC_2536 dehydroabietamide 32.04 µM 0.389738864060725 0.36232247492824 no 1182 0.348364827565584 1757 3983547
SGTC_1472 k841-0093 193 µM 0.388653552169292 0.362701230573571 no 1183 0.348766223080683 1716 X1472
SGTC_2945 9067681 61.76 µM 0.388104853152313 0.362892768494553 no 1184 0.348969220305101 1668 16456930
SGTC_1135 dihydrocapsaicin 536.708 nM 0.386157722396353 0.363572742617728 no 1185 0.349689931270171 1548 107982 A Capsaicinoid.
SGTC_2525 harmine 47.85 µM 0.386051753267035 0.363609761357338 no 1186 0.34972917025843 1717 5280953 A monoamine oxidase inhibitor
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.383766835213536 0.364408272733038 no 1187 0.350575635499656 1713 5282309
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.380987041646638 0.365380522181485 no 1188 0.35160643199393 1679 616764
SGTC_2001 4023502 57.655 µM 0.379624796995751 0.365857291889634 no 1189 0.352111975551123 1696 108941 YCR052W RSC6
SGTC_2612 dictamnine 15.46 µM 0.378685398151566 0.366186191292057 no 1190 0.3524607489012 1663 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1201 1889-3372 45.9 µM 0.377548588747376 0.366584338955051 no 1191 0.35288298137137 1658 5392199
SGTC_2868 9035608 32.47 µM 0.375197746407259 0.367408135614168 no 1192 0.353756703045271 1609 6462614
SGTC_1401 3807-4679 7.6 µM 0.374180021618571 0.367764962625316 no 1193 0.354135193315061 1654 3291456
SGTC_749 1000-0129 128 µM 0.373344063035647 0.368058145553751 no 1194 0.354446192869499 1802 708470
SGTC_2921 7974240 10.71 µM 0.370180107492859 0.369168485889578 no 1195 0.355624148691722 1715 2979074 YDR527W RBA50
SGTC_288 1315-0019 35.1 µM 0.369899458603865 0.369267028078478 no 1196 0.355728702424251 1687 6811474
SGTC_3328 9140624 29.0385 µM 0.369091507608982 0.369550765940026 no 1197 0.356029759357562 1792 4904392
SGTC_347 4534-1311 26.2 µM 0.368811546270496 0.369649099912549 no 1198 0.356134098895187 1651 2862016
SGTC_1175 0741-0056 27.6 µM 0.368727510226393 0.369678618502332 no 1199 0.35616542061521 1774 765927
SGTC_2851 9015922 71.43 µM 0.367589423351261 0.370078459670337 no 1200 0.356589701221562 1760 2996893
SGTC_2208 7283366 200 µM 0.364560089211595 0.371143431408652 no 1201 0.357719905746153 1775 898663
SGTC_1845 st056753 3.01 µM 0.364397638977228 0.371200569258325 no 1202 0.357780549142581 1620 5375839
SGTC_1303 1160-0052 261 µM 0.364127830912664 0.371295473840872 no 1203 0.357881277627452 1705 3562476
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.363983994598054 0.371346071247669 no 1204 0.357934980637941 1651 115019
SGTC_2905 7799065 20.05 µM 0.363809641388125 0.371407406586323 no 1205 0.358000081266367 1786 1296806
SGTC_1282 0886-0010 32.4 µM 0.363577710196006 0.371489002219808 no 1206 0.358086686968849 1803 2836211 YNL267W PIK1
SGTC_2351 9026858 72.31 µM 0.363126214597465 0.371647859292796 no 1207 0.358255301420824 1611 1409300
SGTC_1831 st055328 12 µM 0.363006283077826 0.371690060434427 no 1208 0.358300095403985 1789 1103068
SGTC_2056 5235370 200 µM 0.359314923184058 0.37298971686993 no 1209 0.359679755839301 1657 5511916
SGTC_2948 9070189 9.45 µM 0.359210027784697 0.37302666972117 no 1210 0.359718987745929 1805 6473636 YDL196W YDL196W
SGTC_2460 5552655 174.22 µM 0.359166475666642 0.373042012729081 no 1211 0.359735277098922 1636 5401989
SGTC_2781 5567276 71.43 µM 0.358111893143904 0.373413593802783 no 1212 0.360129789529176 1749 2853274
SGTC_1608 st001473 40.5 µM 0.358075739314366 0.373426334656938 no 1213 0.360143317084683 1627 7292267
SGTC_39 0986-0283 58.349 µM 0.357794115053529 0.373525585687915 no 1214 0.360248697471132 1831 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2883 9059145 45.46 µM 0.357407111685476 0.373661988486412 no 1215 0.360393526763954 1654 16476510
SGTC_665 3914-0008 307 µM 0.356789110649605 0.373879841290163 no 1216 0.360624844456027 1639 1069549
SGTC_1161 k007-0610 110 µM 0.355434088072235 0.374357644005902 no 1217 0.361132207626552 1736 5843850
SGTC_1970 st070122 35.8 µM 0.355302808659299 0.374403945502698 no 1218 0.361181375777432 1744 102928
SGTC_2515 chrysin 20.77 µM 0.355292689677723 0.374407514484722 no 1219 0.36118516574039 1768 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_865 0488-0499 301 µM 0.353829331785351 0.374923756468226 no 1220 0.361733395042439 1753 9634651
SGTC_2832 7992762 51.95 µM 0.35341849985702 0.375068729703057 no 1221 0.361887359336853 1511 2985177
SGTC_3075 9116269 49.47 µM 0.352977523548234 0.375224359845258 no 1222 0.36205264548357 1711 17015205 YNL244C SUI1
SGTC_231 b-estradiol 524 µM 0.35221770186203 0.375492565106582 no 1223 0.362337501170343 1668 450 A steroid.
SGTC_1053 3366-3204 134 µM 0.352025106012474 0.375560558018512 no 1224 0.362409717101411 1638 3632071 YPR165W RHO1
SGTC_1233 0325-0408 14.2 µM 0.351180516782206 0.375858772472611 no 1225 0.362726462902661 1764 12874
SGTC_655 k060-0012 42 µM 0.351156697867983 0.375867183725167 no 1226 0.362735397059265 1682 5994525
SGTC_1257 0669-0121 16 µM 0.350337801252332 0.376156399262796 no 1227 0.36304259966063 1808 4307855
SGTC_290 2043-6722 48.1 µM 0.349730114917805 0.376371065138165 no 1228 0.363270625378227 1722 773758 YLR208W SEC13
SGTC_1548 st061468 90.8 µM 0.34835203994832 0.376858013271033 no 1229 0.363787908016939 1790 390799
SGTC_1558 st069300 45.6 µM 0.347403360502761 0.377193346761382 no 1230 0.364144154531177 1811 24208000
SGTC_1150 3909-7983 10.9 µM 0.34524106024363 0.377958009432474 no 1231 0.364956576301971 1679 23965914
SGTC_1932 st074806 40.9 µM 0.342552806760744 0.378909333838653 no 1232 0.365967455424638 1772 17251235
SGTC_2717 st081029 62.2815 µM 0.342189701422701 0.379037886661726 no 1233 0.366104067508346 1832 5292846
SGTC_2009 4012297 12.05 µM 0.341904240459442 0.379138959877255 no 1234 0.366211479162432 1683 45595307
SGTC_1092 toremifene 6.32 µM 0.341454338427203 0.379298273544075 no 1235 0.36638078706126 1735 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2121 5257820 149.641 µM 0.341412334420194 0.379313148523105 no 1236 0.366396595408769 1846 791256
SGTC_2038 4100038 30.985 µM 0.34135642446587 0.379332948325559 no 1237 0.366417637657426 1734 3596803
SGTC_991 3996-0057 64.7 µM 0.341188785122901 0.379392317573463 no 1238 0.366480732742416 1715 715343
SGTC_1313 1220-0047 237 µM 0.340962663457844 0.379472402762437 no 1239 0.366565844767884 1766 3528706
SGTC_209 4077-0173 175.592 µM 0.339829565976562 0.379873788110055 no 1240 0.366992440566548 1732 15993494
SGTC_255 tunicamycin 200.472 nM 0.337718277764721 0.380622030079137 no 1241 0.367787749778132 1844 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_746 1095-0025 46.6 µM 0.33751183278284 0.380695218344246 no 1242 0.367865546823079 1799 6749286
SGTC_144 4161-2749 112.381 µM 0.337053394581112 0.380857757765908 no 1243 0.368038324761548 1763 797501 YMR168C CEP3
SGTC_310 1273-0058 1.06 µM 0.336892137836565 0.380914936400622 no 1244 0.368099106167844 1736 2734232
SGTC_3308 9128332 17.569 µM 0.335688185455925 0.381341917575945 no 1245 0.368553008002275 1847 17332805 YDL196W YDL196W
SGTC_1516 st013856 110 µM 0.33566194620514 0.381351224925017 no 1246 0.368562902501839 1727 5281404 A mutagen and neurotoxin.
SGTC_488 nitrendipine 139 µM 0.335507108239623 0.381406149040945 no 1247 0.368621291773284 1773 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2754 granisetron 64.02 µM 0.335279318404592 0.381486954981867 no 1248 0.368707196649088 1850 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1777 st045864 34.765 µM 0.331182376268842 0.382941179001445 no 1249 0.370253365745915 1732 4691462
SGTC_2664 lyso-paf C-16 73.48 µM 0.330900040370855 0.383041456182155 no 1250 0.370359995736822 1736 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_565 1418-0001 44.5 µM 0.33039606696815 0.383220471788009 no 1251 0.370550356473077 1801 2862145
SGTC_322 k048-0136 19.3 µM 0.330360493224166 0.383233108824858 no 1252 0.370563794579042 1758 6823282
SGTC_525 k781-2675 26.7 µM 0.32797784942314 0.384079789376022 no 1253 0.371464205353367 1754 3651118 YDL195W SEC31
SGTC_380 3970-0968 6 µM 0.327113374244156 0.38438712062439 no 1254 0.371791068302872 1722 2891601
SGTC_561 1550-0330 72.9 µM 0.326556705190345 0.384585061607215 no 1255 0.372001596961359 1709 6812934
SGTC_268 camptothecin 39.6153 µM 0.325029723054152 0.385128181912351 no 1256 0.372579288107887 1734 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1573 oleylamine 1.06 µM 0.323804184754467 0.385564247143755 no 1257 0.373043143888183 1685 5356789 An amine of the fatty acid oleic acid.
SGTC_3356 9151811 4.48 µM 0.322779449430864 0.385928974708813 no 1258 0.373431138815444 1726 1859254 YPR165W RHO1
SGTC_959 1222-0044 107 µM 0.321915034625766 0.386236718842547 no 1259 0.373758531499388 1901 6083612
SGTC_160 3453-0671 289.699 µM 0.320922064260027 0.38659031894652 no 1260 0.374134726379929 1684 5322268
SGTC_3062 9077494 49.47 µM 0.32037083301983 0.386786654928204 no 1261 0.374343616584661 1812 16459633
SGTC_2186 6124449 200 µM 0.319589513581396 0.387064992707766 no 1262 0.374639762374588 1816 3834182 YLR033W RSC58
SGTC_232 clozapine 119 µM 0.319466415411062 0.38710885058544 no 1263 0.374686427381914 1788 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2367 9070478 135.38 µM 0.317654261340879 0.387754658131526 no 1264 0.375373604800393 1727 572802
SGTC_3055 9094636 49.47 µM 0.316491083288952 0.388169350243649 no 1265 0.375814896061834 1809 25236176
SGTC_3293 9120939 62.045 µM 0.315629687802076 0.388476534132092 no 1266 0.376141800564879 1805 934087
SGTC_3255 9139072 49.47 µM 0.315487412651705 0.388527277863075 no 1267 0.376195803355755 1771 17646060
SGTC_1052 3253-3998 198 µM 0.315467264711768 0.388534463963553 no 1268 0.376203451022021 1726 5450317
SGTC_3077 9117319 49.47 µM 0.315031480557572 0.388689903018589 no 1269 0.376368875942266 1785 17154678
SGTC_2153 5569715 200 µM 0.315029321530225 0.388690673162506 no 1270 0.37636969557183 1774 2054701
SGTC_1107 amlodipine 47 µM 0.314466032096886 0.388891618362789 no 1271 0.37658355565668 1726 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_840 0245-0196 390 µM 0.312998791552986 0.389415174236313 no 1272 0.377140790129228 1826 3827528
SGTC_1735 st034310 56.75 µM 0.312929578434855 0.389439876540238 no 1273 0.377167082494129 1849 871153
SGTC_3219 9131112 49.47 µM 0.310723451865152 0.39022748119168 no 1274 0.378005433579739 1790 17612988 YMR079W SEC14
SGTC_2652 actinonin 100 µM 0.31004602297163 0.390469419281757 no 1275 0.37826297915608 1793 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1015 4130-4525 82 µM 0.309437874624004 0.3906866505379 no 1276 0.378494231673032 1713 1363237
SGTC_368 fentichlor 4.58 µM 0.309344744179476 0.390719919849138 no 1277 0.378529648998309 1717 7329 A pesticide.
SGTC_1816 st051957 91.6 µM 0.309343842117749 0.390720242099685 no 1278 0.378529992055604 1774 674121
SGTC_424 splitomicin 100 mM 0.309088920388997 0.390811312784041 no 1279 0.378626943534045 1690 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1843 st055809 45.5 µM 0.307933431336196 0.391224185808735 no 1280 0.37906649323648 1772 16413835
SGTC_721 1187-1332 279 µM 0.307919479035733 0.391229171918444 no 1281 0.379071801668578 1738 25730
SGTC_3167 9103034 49.47 µM 0.304713786804834 0.392375256970926 no 1282 0.380292074164009 1790 5127859
SGTC_1476 4112-3294 3.34 µM 0.304372926845516 0.392497174846006 no 1283 0.380421895588811 1859 704369
SGTC_3151 9099821 49.47 µM 0.304187632620895 0.392563454814277 no 1284 0.380492473215106 1720 17174189
SGTC_2471 5466956 24.79 µM 0.303687296193655 0.39274244132154 no 1285 0.380683068679187 1810 724419
SGTC_3139 9095020 49.47 µM 0.302923985061389 0.393015546067858 no 1286 0.380973896093137 1739 25236292
SGTC_3129 9127257 49.47 µM 0.302339695109878 0.393224634501799 no 1287 0.381196560512133 1651 837894
SGTC_2446 5162541 200 µM 0.302290230853475 0.393242336724268 no 1288 0.38121541242928 1736 1549321
SGTC_339 3091-4833 71.4 µM 0.300035462604324 0.394049504912019 no 1289 0.382075052877801 1821 3240077
SGTC_36 0335-0881 14.2 µM 0.299347377590447 0.394295918327353 no 1290 0.382337504395943 1797 23828853
SGTC_3251 9135047 49.47 µM 0.298939735070103 0.394441921104835 no 1291 0.382493014178746 1889 17682963
SGTC_3071 9117417 49.47 µM 0.297769481083582 0.394861146006776 no 1292 0.382939554528606 1922 45595590 YGL055W OLE1
SGTC_1101 ebselen 5.29 µM 0.297451115722244 0.394975216429028 no 1293 0.383061061929833 1913 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1293 1000-1278 195 µM 0.296115359802634 0.395453916268361 no 1294 0.383570992151652 1859 678847
SGTC_471 1-acyl-paf 4 µM 0.294453954506761 0.396049540398192 no 1295 0.38420552175004 1724 16759367
SGTC_1765 st044815 90.4 µM 0.292891700980142 0.396609839508975 no 1296 0.384802466244639 1725 645695
SGTC_1941 st076221 61.8 µM 0.292234449274146 0.396845625410895 no 1297 0.385053686969129 1922 2828568
SGTC_2457 5731572 11.68 µM 0.289509622999566 0.397823545196522 no 1298 0.386095708479574 1917 2865357
SGTC_1534 6-azauridine 81.6 µM 0.288617352999712 0.398143914143914 no 1299 0.386437107302833 1798 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2025 5147754 141 µM 0.287816933670455 0.398431362614972 no 1300 0.386743437205157 1901 315777 YLR208W SEC13
SGTC_2927 9011802 47.9 µM 0.287316328648687 0.398611169093585 no 1301 0.386935060527831 1723 43912568
SGTC_91 0417-1751 58.384 µM 0.286958585888946 0.39873967573162 no 1302 0.387072015428869 1845 6795624
SGTC_2843 9000894 45.46 µM 0.284358709781676 0.399673919738045 no 1303 0.388067749124949 1795 2242070
SGTC_610 4215-0184 155 µM 0.284100482672629 0.399766742977967 no 1304 0.388166688540423 1824 5605015
SGTC_2752 diclazuril 33.15 µM 0.283076081077946 0.400135033800307 no 1305 0.388559258271721 1918 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1638 st008370 60.6 µM 0.282204288704015 0.400448528842498 no 1306 0.388893435004426 1797 24207134
SGTC_1223 0764-0573 147 µM 0.281869206372525 0.400569040950558 no 1307 0.389021901144248 1802 1609797
SGTC_1253 0550-0034 176 µM 0.281558806947485 0.400680684315496 no 1308 0.389140915010365 1801 5969915
SGTC_22 0964-0034 14.468 µM 0.280963150598678 0.40089495059676 no 1309 0.389369331686713 1797 138402
SGTC_1838 st055369 84.5 µM 0.279537919420192 0.401407747959412 no 1310 0.389916020923269 1801 676036
SGTC_2317 5986382 200 µM 0.279386705797477 0.401462164516076 no 1311 0.389974036145643 1907 877883
SGTC_3273 9137859 49.47 µM 0.277680048262519 0.402076463840754 no 1312 0.390628988841217 1930 2377234
SGTC_2048 5246248 200 µM 0.277151759660566 0.402266666704814 no 1313 0.390831789677048 1955 677046
SGTC_1035 k081-0041 55.2 µM 0.276636179326634 0.402452316451331 no 1314 0.391029740662066 1930 731709
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.275292277304696 0.402936330919095 no 1315 0.391545848580414 1819 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1374 2889-5571 141 µM 0.274826604252354 0.403104080640137 no 1316 0.39172472879578 1794 2853281
SGTC_2876 9059903 25.97 µM 0.274671003637153 0.40316013673252 no 1317 0.391784505174527 1838 6916095
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.271794352545322 0.404196825568191 no 1318 0.392890073917155 1852 97141
SGTC_3351 9150312 21.596 µM 0.271756045826019 0.404210635118769 no 1319 0.392904801997613 1892 4904905
SGTC_974 1326-0144 138 µM 0.271159202841102 0.404425812083618 no 1320 0.393134294624952 1791 5411856
SGTC_2874 9043904 71.43 µM 0.268482804137835 0.40539107602504 no 1321 0.394163854727922 1813 4463428
SGTC_2701 st077767 14.721 µM 0.268258650301922 0.40547194505197 no 1322 0.39425011616275 1815 5721188
SGTC_3011 9081274 71.4286 µM 0.267647207295285 0.405692558709984 no 1323 0.394485444993191 1804 6625322
SGTC_269 exalamide 29 µM 0.267235952226303 0.405840959771789 no 1324 0.394643748257667 1849 3316 A derivative of salicylamide.
SGTC_2178 5812956 200 µM 0.266271625508507 0.40618898932655 no 1325 0.395015012033086 1861 5403383
SGTC_1299 1079-1439 3.74 µM 0.265815495516507 0.406353634397032 no 1326 0.395190654362802 1809 323161
SGTC_2847 9005661 71.43 µM 0.265537238451253 0.406454082438455 no 1327 0.395297813487813 1904 2991449
SGTC_1635 st007035 42.4 µM 0.264677439212592 0.406764500310594 no 1328 0.395628979370563 1827 3716403
SGTC_1937 st074714 47.2 µM 0.263947930794642 0.407027924550886 no 1329 0.395910020704867 1717 17250970
SGTC_307 1501-1223 22.3 µM 0.263844980678892 0.407065103050991 no 1330 0.395949686346166 1855 2830329
SGTC_2141 5621638 7.665 µM 0.263332417957885 0.407250217904959 no 1331 0.396147187621436 1947 2856238
SGTC_2158 5657123 3.6195 µM 0.262968511471736 0.407381657318277 no 1332 0.396287424685676 1931 2858827
SGTC_2984 9022109 38.96 µM 0.262370197931742 0.407597784896858 no 1333 0.396518023343828 1995 6459207
SGTC_2707 st078556 66.6 µM 0.261577236651532 0.407884268013655 no 1334 0.396823697816709 1988 17250899
SGTC_3324 9138759 60.749 µM 0.259192377507576 0.408746172399017 no 1335 0.397743406033837 1877 45595710
SGTC_586 0957-0265 8.15 µM 0.259127380487131 0.408769668965399 no 1336 0.397768479771114 1966 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.258482695002725 0.409002741933382 no 1337 0.39801720132261 1985 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_559 1550-0661 158 µM 0.258154732446736 0.409121322500883 no 1338 0.398143746151881 1892 5830875
SGTC_889 0919-1524 82.7 µM 0.257661698234787 0.409299603244022 no 1339 0.398334004276471 1835 3905452
SGTC_516 3992-2719 87.3 µM 0.257601744426915 0.40932128376903 no 1340 0.398357141640741 1730 5350887 YDR037W KRS1
SGTC_3282 9108498 15.4605 µM 0.257563948025032 0.409334951864711 no 1341 0.398371728205969 1821 16459645
SGTC_2939 9044578 71.43 µM 0.256865862579507 0.409587416293839 no 1342 0.398641162136386 1800 2653634
SGTC_2529 gangaleoidin 93.61 µM 0.256518542074103 0.40971303963911 no 1343 0.398775232400164 1859 4565183
SGTC_2677 mitomycin C 100 µM 0.256452890208275 0.409736786491959 no 1344 0.398800576223033 1856 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2120 5538279 151.968 µM 0.254929918482655 0.410287751414248 no 1345 0.399388613955758 1876 2058197
SGTC_2623 humulene 100 µM 0.252662256643448 0.411108450516997 no 1346 0.400264608262844 1796 6187145 An anti-inflammatory.
SGTC_2944 9067346 25.62 µM 0.249750641349442 0.412162775797927 no 1347 0.401390096361325 1889 6473075
SGTC_3230 9131665 49.47 µM 0.248143937913439 0.412744851403353 no 1348 0.402011520469643 1892 15943720
SGTC_2533 agelasine 13.65 µM 0.247527072598675 0.412968380074739 no 1349 0.40225017116154 2026 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2910 7948405 25.97 µM 0.247366120928945 0.413026707520695 no 1350 0.402312445577865 1984 2971328
SGTC_1565 sinapyl alcohol 95.1 µM 0.246252807611285 0.413430214817002 no 1351 0.402743269632763 1810 5280507 A phenol propionate derived from cinnamic acid.
SGTC_634 1611-4317 11.2 µM 0.246180036023229 0.413456593210469 no 1352 0.402771434512671 2009 2843522
SGTC_2012 4023501 200 µM 0.245497724493336 0.413703937868823 no 1353 0.403035534933644 1827 3477460
SGTC_596 1155-0152 116 µM 0.245080067479169 0.413855359557685 no 1354 0.403197218106007 1831 280313
SGTC_2597 laccaic acid a 100 µM 0.243670147907943 0.414366620845164 no 1355 0.403743147543671 1866 5491415 A textile dye.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.242663928739365 0.414731582164231 no 1356 0.404132876499002 1906 368090
SGTC_235 0330-0087 5 mM 0.240384523792702 0.415558606875429 no 1357 0.405016087372195 1875 46494818 YHR062C RPP1
SGTC_148 3253-0744 288.01 µM 0.238984760051255 0.416066661606675 no 1358 0.405558700053495 1933 6893655
SGTC_177 1327-0068 8.361 µM 0.238850399838321 0.416115436044907 no 1359 0.405610793805093 1942 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_819 1013-0258 27.7 µM 0.238598562606245 0.416206859590394 no 1360 0.405708439908192 1870 5753198
SGTC_2353 9059630 146.67 µM 0.238076812609757 0.416396282997256 no 1361 0.405910759294413 1958 4779114
SGTC_3261 9137475 49.47 µM 0.237269159450481 0.416689542961404 no 1362 0.406223993109603 1955 17027690
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.237068386338415 0.416762451155098 no 1363 0.406301868689733 1849 6708514
SGTC_405 ebelactone b 50 µM 0.236589784223424 0.416936260949099 no 1364 0.406487523120125 1876 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_677 0929-0063 136 µM 0.23598533221495 0.417155797759977 no 1365 0.406722025989462 1896 1539583
SGTC_1782 st039423 80.636 µM 0.235696089755326 0.417260859687779 no 1366 0.406834252174046 1831 2068169
SGTC_2722 naftopidil 47.16 µM 0.235535818632466 0.417319077727617 no 1367 0.406896440725705 1961 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_757 1066-0008 322 µM 0.235413193525032 0.417363622181089 no 1368 0.406944023420419 1962 6842497
SGTC_1662 st014054 52 µM 0.234890386435401 0.417553547515088 no 1369 0.407146905681563 1989 2838777
SGTC_649 1123-0311 367 µM 0.234402807456402 0.417730692518374 no 1370 0.40733613965994 1987 693629 YIL048W NEO1
SGTC_1498 4478-3555 97.6 µM 0.231779727943306 0.418683983614544 no 1371 0.408354551546883 2020 3437919
SGTC_794 k038-0031 316 µM 0.231660056185218 0.418727486688303 no 1372 0.408401028988002 1856 6624242
SGTC_953 1188-0045 9.7 µM 0.228402582005525 0.419912023604401 no 1373 0.409666641175426 1926 6144426
SGTC_1440 4100-1550 40 µM 0.228377781129103 0.419921044909361 no 1374 0.409676280580779 1977 742806
SGTC_3281 9140613 49.47 µM 0.227984682875715 0.420064039795717 no 1375 0.409829074138238 1814 16013766
SGTC_3020 9089140 49.47 µM 0.226195558149069 0.420714991516984 no 1376 0.410524662588675 1880 17217859
SGTC_2238 6671620 73.2395 µM 0.225277479296265 0.421049107875914 no 1377 0.410881709161283 1929 729941
SGTC_863 0466-0191 129 µM 0.224813128714698 0.42121812061479 no 1378 0.411062326130084 2011 765160 YPR165W RHO1
SGTC_1764 st044502 93.5 µM 0.222438164851555 0.422082778220297 no 1379 0.411986402324207 1913 8407
SGTC_822 1487-0950 154 µM 0.218142463743793 0.423647673898881 no 1380 0.413659056353775 2029 1958375
SGTC_1667 st014849 34.6 µM 0.216737227365351 0.424159855046878 no 1381 0.414206567135251 1973 5348460
SGTC_2724 maprotiline 69.64 µM 0.215953089301686 0.424445713766549 no 1382 0.414512157013267 1991 4011 A tricyclic antidepressant.
SGTC_3044 9093193 49.47 µM 0.215404600667624 0.424645689762984 no 1383 0.414725941691157 1850 25236277
SGTC_151 3013-0144 2.285 µM 0.214668966670791 0.424913928393408 no 1384 0.415012709753605 2030 906558 YHR107C CDC12
SGTC_3096 9117468 49.47 µM 0.214211025781096 0.425080927690297 no 1385 0.415191249155622 2018 41316311
SGTC_1674 st016616 23.6 µM 0.213846356815489 0.425213922726469 no 1386 0.415333436756651 1823 625830
SGTC_1676 st018489 23.4 µM 0.213801743658813 0.425230193761668 no 1387 0.415350832576047 1896 3696235
SGTC_839 0122-0028 230 µM 0.212803575567255 0.425594272719681 no 1388 0.415740087361788 1949 759448
SGTC_639 0833-0042 114 µM 0.212515358768449 0.425699410792164 no 1389 0.415852498430599 1885 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2896 9052656 71.43 µM 0.212494962384426 0.425706851351575 no 1390 0.415860453742558 1989 6469436
SGTC_3025 9087895 49.47 µM 0.212475047945916 0.425714116123767 no 1391 0.41586822111197 2045 17173641
SGTC_3170 9103054 49.47 µM 0.21220453628019 0.425812801072671 no 1392 0.415973733945897 1914 16432970
SGTC_1602 st001878 87.6 µM 0.21215193653186 0.425831990446582 no 1393 0.415994251134429 1986 595405 YLR310C CDC25
SGTC_820 1582-0060 59.9 µM 0.211633933343908 0.426020977092247 no 1394 0.416196316966322 1909 3848840
SGTC_2818 7996756 12.99 µM 0.21147841248921 0.426077720147872 no 1395 0.416256987812866 1919 2241621
SGTC_256 clotrimazole 625 nM 0.210108744319292 0.42657752074724 no 1396 0.41679140041485 1998 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_653 0203-0016 55.2 µM 0.209854378932257 0.426670353297242 no 1397 0.416890664825159 1966 295302
SGTC_1154 4088-0362 150 µM 0.208086930361013 0.427315508772567 no 1398 0.417580545933176 1984 6618304
SGTC_777 1315-0167 517 µM 0.208054345345075 0.427327404811486 no 1399 0.417593267100449 1882 4221767
SGTC_3305 9127027 53.8275 µM 0.206915336406533 0.42774327219418 no 1400 0.418037989491248 1941 41905295
SGTC_3113 9123498 49.47 µM 0.206607652482373 0.427855625498539 no 1401 0.418158141699485 2069 8897275
SGTC_2440 5628896 157.78 µM 0.206586390325464 0.427863389765431 no 1402 0.418166444967083 1924 5522048
SGTC_1615 st002656 86.5 µM 0.205841143478774 0.42813554795772 no 1403 0.418457500733839 2005 1584458
SGTC_2292 7671323 168.05 µM 0.204239263939179 0.42872065712207 no 1404 0.419083264890048 1928 937504
SGTC_2014 4013930 200 µM 0.203590848124091 0.428957544795715 no 1405 0.419336622749988 2094 64556
SGTC_1129 3453-1384 223 µM 0.203396528548271 0.429028541130679 no 1406 0.419412556460266 1965 1084452
SGTC_2661 dactinomycin 12.96 µM 0.202532702381486 0.429344175240212 no 1407 0.419750147652197 1991 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2841 9004761 38.96 µM 0.202282542724014 0.429435589715359 no 1408 0.419847923382064 1812 2991039
SGTC_365 0121-0052 13.6 µM 0.201431787970269 0.429746504659864 no 1409 0.420180480683815 1984 3101739
SGTC_2092 5303694 80.6725 µM 0.201409082733758 0.429754803063077 no 1410 0.420189356869743 1917 1963699
SGTC_2304 7443016 91.4 µM 0.200014606995825 0.430264521136883 no 1411 0.420734578610242 1951 939854
SGTC_2960 9079389 5.97 µM 0.199479044440431 0.430460314472403 no 1412 0.420944017030197 2049 16457355
SGTC_1478 0453-0656 35.7 µM 0.198661064152112 0.430759388318391 no 1413 0.421263941595848 2023 5258496
SGTC_2290 7904846 200 µM 0.196818563632409 0.431433197353618 no 1414 0.421984761788414 1912 2962154
SGTC_3283 9109332 35.8195 µM 0.196429631789353 0.431575456697248 no 1415 0.422136952598098 1997 17027281
SGTC_834 0312-0008 75.7 µM 0.196279768669697 0.431630274401389 no 1416 0.422195597827026 1951 6385573 YIL048W NEO1
SGTC_2418 pentamidine 31.67 µM 0.195876233879867 0.431777887979332 no 1417 0.422353519769049 2081 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3252 9135871 49.47 µM 0.19558959824317 0.431882745475029 no 1418 0.4224657012165 2030 17682838
SGTC_2852 9023854 51.95 µM 0.195369829640644 0.431963144818855 no 1419 0.422551716972751 2014 19798528
SGTC_920 mycophenolic acid 780.421 nM 0.195141184480401 0.432046794521177 no 1420 0.422641210866027 1911 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1971 st069429 63.5 µM 0.194863839789582 0.432148265007848 no 1421 0.422749771578411 2063 1246522 YGL099W LSG1
SGTC_767 0929-0023 86 µM 0.194413027337217 0.432313210682061 no 1422 0.422926245092508 2058 1204563
SGTC_139 0099-0334 718.624 µM 0.192827523813536 0.432893416726693 no 1423 0.42354702355607 2114 97690
SGTC_2247 cerulenin 830 nM 0.192686981926076 0.432944854235263 no 1424 0.423602059657661 2048 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2923 7992654 58.14 µM 0.191657198726075 0.433321783468095 no 1425 0.424005367417165 1936 2985126
SGTC_2617 dihydrotanshinone i 20.83 µM 0.190997471069295 0.433563294002365 no 1426 0.424263787240175 1944 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2467 5474540 200 µM 0.190687070470737 0.433676932833624 no 1427 0.42438538454359 2040 5413519
SGTC_557 1315-0110 16.2 µM 0.190549867752302 0.433727165014812 no 1428 0.424439135061066 1982 6833801
SGTC_1159 4092-0538 61.2 µM 0.189415974216063 0.434142343068843 no 1429 0.424883402737896 1963 717301
SGTC_1841 st054148 70 µM 0.189147754634 0.43424056300646 no 1430 0.424988507084398 1937 675442
SGTC_2332 7982454 138.89 µM 0.188965411864697 0.434307337837483 no 1431 0.425059962845562 2051 2981748
SGTC_1453 4237-0541 195 µM 0.188893235814972 0.434333769584561 no 1432 0.425088247589943 2077 739892
SGTC_3176 9106582 49.47 µM 0.188341302045784 0.434535904139527 no 1433 0.425304555147651 2078 17018027
SGTC_2366 9070441 60.58 µM 0.187506971590836 0.434841493229129 no 1434 0.425631579045735 1964 6837235
SGTC_630 4356-0227 183 µM 0.184752026128903 0.435850818901323 no 1435 0.426711768787708 2036 779312
SGTC_1419 3993-2473 62.6 µM 0.184300332035424 0.43601634551625 no 1436 0.426888926730984 2004 704026
SGTC_1125 tnp00248 1.32998 µM 0.184140422091865 0.436074948376172 no 1437 0.426951648193636 2097 24207736
SGTC_210 3551-0445 56.827 µM 0.180940675712231 0.437247866012999 no 1438 0.428207070579894 2042 2865180 YOR207C RET1
SGTC_1790 st045711 43.5 µM 0.178488574587087 0.438147096446229 no 1439 0.429169646642588 2101 585119
SGTC_1138 3761-0006 1.03 µM 0.177912849356473 0.438358271922698 no 1440 0.429395709756018 2088 12061087
SGTC_1866 st057638 64 µM 0.177857651124223 0.438378519505744 no 1441 0.429417385000755 1974 688802
SGTC_1691 st019933 84.6 µM 0.17666697767966 0.438815316501453 no 1442 0.429884990407067 2124 6176082
SGTC_962 1254-0300 21.5 µM 0.175851071902161 0.439114673533109 no 1443 0.430205472594555 1988 7340576
SGTC_2436 5633522 8.09 µM 0.175715718291042 0.439164338344967 no 1444 0.43025864301636 2120 5724242
SGTC_1362 1611-0397 101 µM 0.174792985682164 0.439502938768455 no 1445 0.430621150052134 1989 27816
SGTC_1774 st048371 48.465 µM 0.174667436202319 0.439549013079034 no 1446 0.430670478260017 1921 4242727
SGTC_2983 9022671 12.99 µM 0.174421519066352 0.439639262440009 no 1447 0.430767101878641 2136 6405161
SGTC_606 k015-0008 38.6 µM 0.174356245192782 0.439663217887273 no 1448 0.430792749416658 2082 1970475
SGTC_2795 7780010 54.55 µM 0.174021715001799 0.439785993603302 no 1449 0.430924198252443 1999 953673
SGTC_457 grayanotoxin iii 135 µM 0.172377190173299 0.440389633620816 no 1450 0.431570501680072 2027 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1202 1988-0068 29.6 µM 0.171977894394682 0.440536220267292 no 1451 0.431727453887759 1921 2850480
SGTC_2999 9069765 71.4286 µM 0.171228431498492 0.44081137978058 no 1452 0.432022076257248 2047 2097066
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.170305330609002 0.441150328406208 no 1453 0.432385009641541 2120 1241132 A phosphatase inhibitor.
SGTC_754 3474-0146 171 µM 0.168560431371933 0.44179114647012 no 1454 0.433071203158176 1901 24762078
SGTC_2181 6316240 54.2555 µM 0.168433716775862 0.441837688637766 no 1455 0.433121042422652 1970 12779990
SGTC_2867 9039098 71.43 µM 0.167204130664958 0.442289356217938 no 1456 0.433604717187088 1995 6463460
SGTC_3226 9131256 49.47 µM 0.165613196845802 0.442873870006073 no 1457 0.434230680568367 2074 17178073
SGTC_2757 clomiphene 4.22 µM 0.165457443311922 0.442931101018427 no 1458 0.434291971711072 2133 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1587 estradiol valerate 56.1 µM 0.164210543961489 0.443389312015802 no 1459 0.434782700450744 2120 13791 A steroid.
SGTC_895 0964-0006 13.7 µM 0.163658144785577 0.443592332088534 no 1460 0.435000134405798 2111 6738897
SGTC_1998 st075797 76.8 µM 0.16339180322413 0.443690224355268 no 1461 0.43510497812009 2139 24208315
SGTC_1082 camptothecin 424.86 nM 0.163275544068393 0.443732955798495 no 1462 0.435150744251201 1851 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2051 5263410 176 µM 0.162852390315878 0.443888492902209 no 1463 0.435317328657376 2151 227584
SGTC_1853 st056710 91.2 µM 0.162732171433332 0.443932682902386 no 1464 0.435364657737357 2153 269167
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.157173794062381 0.44597658093023 no 1465 0.43755394044623 1955 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_941 3237-0776 460 µM 0.156977172263521 0.446048908313558 no 1466 0.437631419466409 2108 760008
SGTC_4 0960-0234 25.671 µM 0.154624605128857 0.446914439356449 no 1467 0.43855863559977 2026 6821112
SGTC_661 1304-0007 33.6 µM 0.154022844626104 0.447135873354346 no 1468 0.43879586155303 2002 3117130
SGTC_3087 9117406 49.47 µM 0.152851557794773 0.447566927113694 no 1469 0.43925766908317 2021 42546093
SGTC_35 0133-0054 64.071 µM 0.152551461275956 0.447677377796667 no 1470 0.439376002563133 1998 99677
SGTC_1955 wogonin 32.4 µM 0.151334223956208 0.448125424153509 no 1471 0.439856036676385 2117 5281703 A flavanone.
SGTC_1385 3091-4834 14.1 µM 0.150132735679113 0.448567738439147 no 1472 0.440329946669291 2077 4072814
SGTC_805 3852-0218 479 µM 0.149693974573323 0.44872927933233 no 1473 0.440503031104242 1961 6615355
SGTC_2069 5228469 200 µM 0.149399379686194 0.448837746591786 no 1474 0.440619250588328 2034 2835210
SGTC_3027 9089541 49.47 µM 0.14911734196342 0.448941593996389 no 1475 0.440730520987225 2041 9943819
SGTC_1923 st058458 19.1 µM 0.148891853456332 0.449024622272817 no 1476 0.4408194847806 2169 3534982
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.148148680255753 0.449298285661373 no 1477 0.441112715998326 2036 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2264 7948757 110.76 µM 0.147039313179361 0.449706839782986 no 1478 0.441550495057908 1973 2971411
SGTC_1513 0337-0559 19 µM 0.146757076390888 0.449810789560116 no 1479 0.441661882914887 1971 775073
SGTC_2966 9084041 48.03 µM 0.146684284716246 0.449837599800376 no 1480 0.441690611699745 1878 17741380
SGTC_3144 9087057 49.47 µM 0.146441479267178 0.449927030259617 no 1481 0.441786442259241 2200 17249618
SGTC_1194 1488-0194 225 µM 0.146109781026317 0.450049205951447 no 1482 0.441917362570205 2044 1391452
SGTC_2601 securinine 100 µM 0.145337610910019 0.450333640666996 no 1483 0.442222160377035 2028 442872 A GABA receptor antagonist.
SGTC_814 3342-0569 96 µM 0.144648994257028 0.450587319356477 no 1484 0.442494006084398 2134 4346283
SGTC_866 0495-0101 262 µM 0.144336303580686 0.450702517782654 no 1485 0.442617456162371 1931 635694
SGTC_1252 0493-0875 34.8 µM 0.143539018712298 0.450996264410681 no 1486 0.442932248903144 2055 3960963
SGTC_3050 9093513 49.47 µM 0.142577644968444 0.451350502593035 no 1487 0.44331187690497 2109 25236664
SGTC_2152 5568786 200 µM 0.141568102903112 0.451722531097996 no 1488 0.443710581660055 2132 5399883
SGTC_1980 st071811 45.7 µM 0.138230497475125 0.452952779258499 no 1489 0.445029126476577 2126 4974850
SGTC_29 0299-0004 12.984 µM 0.137965053784956 0.453050641890708 no 1490 0.445134018208594 2136 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2954 9074818 52.69 µM 0.137713820784403 0.453143268014059 no 1491 0.44523329803641 2090 16648742
SGTC_1609 st001574 46.4 µM 0.137294159177786 0.453297997112384 no 1492 0.445399143510188 2111 3960012
SGTC_79 0052-0007 94.094 µM 0.136925612760043 0.453433885905401 no 1493 0.445544796726925 2141 2801472
SGTC_788 1182-0090 188 µM 0.136251077114301 0.453682611794166 no 1494 0.44581139895954 2161 5715185
SGTC_58 0957-0393 9 µM 0.135799925874618 0.453848977852425 no 1495 0.445989724831202 2079 6997992
SGTC_2269 7935389 174.42 µM 0.135583879815995 0.453928649639999 no 1496 0.446075124902696 2053 97605
SGTC_184 1494-0393 24.714 µM 0.134628028536803 0.45428116325425 no 1497 0.446452989889952 2057 3090647
SGTC_2325 6158266 200 µM 0.133307646955194 0.454768173169562 no 1498 0.446975040091843 2066 3623240
SGTC_2364 9055074 200 µM 0.131424265646151 0.455462957555093 no 1499 0.447719846967427 2052 6470630
SGTC_792 4534-1957 155 µM 0.129007939683602 0.456354545877742 no 1500 0.448675683186273 2055 1717904
SGTC_1005 4092-0690 4.4 µM 0.128850075067455 0.456412803269436 no 1501 0.448738140786314 2046 1529343
SGTC_644 1498-1197 63.3 µM 0.128375513402179 0.456587938238548 no 1502 0.448925904137605 2138 6741615
SGTC_2176 5809774 33.9695 µM 0.127397525152984 0.456948887212805 no 1503 0.449312887461547 2187 2870539
SGTC_3047 9092122 49.47 µM 0.126616354797588 0.457237221564848 no 1504 0.449622025935146 2067 17173831
SGTC_706 4262-0057 46.9 µM 0.126287992945536 0.457358428491868 no 1505 0.449751980201854 2147 883298
SGTC_1966 st070145 16.1 µM 0.126000592500405 0.457464518750355 no 1506 0.449865727783185 2139 3748532
SGTC_948 3448-0295 75.3 µM 0.125927353478607 0.457491554498745 no 1507 0.449894715041614 2150 678569
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.124987297103983 0.457838588129813 no 1508 0.450266803458856 2157 6708784 An antioxidant flavonoid
SGTC_2032 5185112 25.99 µM 0.124004378224875 0.458201479366829 no 1509 0.450655904250022 2161 5718189
SGTC_334 1502-1024 68.5 µM 0.123836496109823 0.458263464523728 no 1510 0.45072236724759 2095 3296216
SGTC_923 1900-2434 73.3 µM 0.123736319998336 0.458300451865568 no 1511 0.450762026714475 2187 5910570
SGTC_1479 0549-0158 134 µM 0.123619356071826 0.458343638114642 no 1512 0.450808333056536 2124 5440202
SGTC_1093 fluphenazine 7.97 µM 0.120858509862172 0.459363158981217 no 1513 0.451901552768144 2145 6602611 An atypical antipsychotic.
SGTC_2711 st079103 59.1 µM 0.119352810599452 0.459919294266031 no 1514 0.452497922830607 2164 54693780
SGTC_1459 k035-0031 35.7 µM 0.117926318718475 0.460446246392708 no 1515 0.453063019712668 2090 3877128 YMR208W ERG12
SGTC_1905 st060207 84.5 µM 0.117799527052345 0.460493087145268 no 1516 0.453113252148349 2060 1948547
SGTC_1994 st072947 40.9 µM 0.11743167960013 0.460628984441051 no 1517 0.453258990523957 2114 5286565 YDL195W SEC31
SGTC_2098 5376439 882.5 nM 0.117364373013943 0.460653850635556 no 1518 0.453285657565754 2154 2844116
SGTC_2486 5283202 22.39 µM 0.116941969726127 0.460809909634846 no 1519 0.453453019634642 2062 1377751
SGTC_821 1114-0266 29.2 µM 0.116504321885393 0.460971607176612 no 1520 0.453626430527727 2119 3123235
SGTC_1847 st056231 15 µM 0.116155959681975 0.461100321009843 no 1521 0.453764469749966 2203 5393180
SGTC_2059 5238311 157 µM 0.115343512399194 0.461400522097287 no 1522 0.454086425292173 2116 703021
SGTC_2669 eugenol 100 µM 0.11525207753445 0.461434308864404 no 1523 0.454122660873068 2201 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2659 sanguinarine 24.21 µM 0.115055536685375 0.461506935056144 no 1524 0.454200551183357 2145 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1191 1487-1166 10.6 µM 0.11380512466219 0.461969019923368 no 1525 0.454696138048639 2149 3955771
SGTC_2784 7567673 72.73 µM 0.11265622632218 0.462393636077606 no 1526 0.455151553287918 2208 3471247
SGTC_2589 lobaric acid 100 µM 0.111527801401358 0.462810727277722 no 1527 0.455598910393058 2084 73157 A novel microtubule depolymerizer.
SGTC_3134 9127454 49.47 µM 0.110813941114514 0.463074607221414 no 1528 0.455881945015521 2223 24262820
SGTC_1837 st055472 66.5 µM 0.108665968441428 0.463868707337949 no 1529 0.4567337176085 2165 676091
SGTC_3173 9105693 49.47 µM 0.10860750355136 0.46389032368829 no 1530 0.456756904495439 2173 17096658
SGTC_346 4513-0042 7.16 µM 0.108404817483944 0.463965264071629 no 1531 0.45683728992921 2171 2827372
SGTC_456 gingerol 170 µM 0.108202378637218 0.464040114324707 no 1532 0.456917579078116 2159 442793 A herb.
SGTC_2412 st077135 33.4 µM 0.107578187152189 0.464270912469757 no 1533 0.457165150343748 2167 13258915
SGTC_743 1275-0778 158 µM 0.107385625380295 0.46434211564664 no 1534 0.457241528922985 2192 2849257 YMR203W TOM40
SGTC_681 1642-0006 26.6 µM 0.10675339821766 0.464575901023393 no 1535 0.457492309478089 2227 4446530
SGTC_1695 st026914 34.495 µM 0.106425344902966 0.464697213618694 no 1536 0.457622442471697 2110 3289191
SGTC_782 0083-0095 30.5 µM 0.105884880493435 0.464897082003786 no 1537 0.457836845121524 2251 3591729 An indicator and reagent.
SGTC_573 3702-0553 84.7 µM 0.105684387534978 0.464971228278358 no 1538 0.457916383956843 2201 1222756
SGTC_1124 fisetin 1.16336 µM 0.105600712948963 0.465002173160555 no 1539 0.457949579532106 2061 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3332 9141069 11.198 µM 0.105590443423928 0.465005971093452 no 1540 0.45795365370204 2172 17332883
SGTC_3236 9132701 49.47 µM 0.105406729668168 0.465073913675252 no 1541 0.458026538155702 2116 24282524
SGTC_1007 4101-0031 70 µM 0.102611085331747 0.466107947102496 no 1542 0.45913582223108 2229 1146276
SGTC_480 am 92016 50 µM 0.102189026599991 0.466264075295279 no 1543 0.45930331883113 2080 2129 K+ channel blocker.
SGTC_2381 9035592 200 µM 0.101847955428258 0.466390248320554 no 1544 0.459438680299814 2056 4749657
SGTC_2665 lovastatin 100 µM 0.100982245756372 0.466710516876918 no 1545 0.459782276978921 2146 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_521 r062-0005 13.8 µM 0.100980550388788 0.466711144097928 no 1546 0.459782949893035 2099 2832033
SGTC_3253 9135987 49.47 µM 0.0996684378957665 0.467196600088481 no 1547 0.460303779324424 2187 4182430
SGTC_2922 7999257 32.47 µM 0.098260559466201 0.467717541855902 no 1548 0.460862697781335 2241 2988377
SGTC_3035 9091303 49.47 µM 0.0973772902063305 0.468044396546222 no 1549 0.461213389399043 2229 25237002
SGTC_2257 7960413 200 µM 0.0972050090881883 0.46810815186742 no 1550 0.461281795104351 2161 2974689 YIL048W NEO1
SGTC_1066 ketoconazole 628 nM 0.0970481168655331 0.468166212998956 no 1551 0.461344091512553 2202 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_908 3448-7491 47.7 µM 0.0969939835587958 0.468186246278184 no 1552 0.461365586173416 2174 1203031
SGTC_198 3454-2873 16.191 µM 0.0956641012618485 0.468678425084361 no 1553 0.461893676567699 2153 710957
SGTC_359 0081-0058 15.9 µM 0.0953776976679011 0.468784427055706 no 1554 0.462007414996291 2217 3494159
SGTC_394 menadione 8.33 µM 0.0928873628217191 0.469706227240463 no 1555 0.462996522673817 2250 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_522 1273-0010 11.6 µM 0.0926449129312922 0.469795979087791 no 1556 0.463092830900019 2160 5705015
SGTC_1844 rapamycin 4 nM 0.0911728107636142 0.470340965257076 no 1557 0.463677639411058 2126 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_858 0438-0351 2.77 µM 0.0907895256492066 0.470482870194883 no 1558 0.46382991649934 2141 2799119
SGTC_995 3931-2021 34.6 µM 0.0901764671746388 0.470709852682291 no 1559 0.464073492299201 2156 730143
SGTC_3206 9114350 49.47 µM 0.0900660585012863 0.470750732072445 no 1560 0.464117360479679 2257 17087243
SGTC_3203 9113543 49.47 µM 0.0896459387617457 0.470906286422731 no 1561 0.464284288745482 2162 17018012
SGTC_1785 bathophenanthroline 24 µM 0.0885190364979461 0.47132355730017 no 1562 0.464732077395314 2081 72812 An iron chelator.
SGTC_1655 st012546 55.1 µM 0.0880483582484024 0.471497850019047 no 1563 0.464919120517579 2203 720985 YLR208W SEC13
SGTC_2793 7325131 81.82 µM 0.0873288757556675 0.471764285785612 no 1564 0.465205051079857 2178 4176441
SGTC_1949 st076024 69.1 µM 0.0872833186316014 0.471781156737121 no 1565 0.465223156607783 2265 2921930
SGTC_2423 st077119 87.2 µM 0.0863701651561049 0.472119331127944 no 1566 0.465586081519264 2244 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1172 0370-0043 85 µM 0.0859078272539912 0.472290559575027 no 1567 0.465769844633993 2189 376585
SGTC_1128 3448-9350 235 µM 0.0848643270252036 0.472677042281941 no 1568 0.466184626175838 2086 619386
SGTC_597 k018-0003 82.8 µM 0.0840298365937195 0.472986132253901 no 1569 0.466516354741112 2227 6786234
SGTC_3059 1327-0034 3 µM 0.083266708853379 0.473268804180773 no 1570 0.466819735413578 2180 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3352 9151559 45.5865 µM 0.0827495074411775 0.473460389624495 no 1571 0.467025359290573 2183 17159339
SGTC_1852 st056254 31.4 µM 0.0818295407588945 0.473801185401353 no 1572 0.467391132356761 2178 442583
SGTC_1776 st049249 45.9 µM 0.0817175529185371 0.473842671895066 no 1573 0.467435659916033 2160 1822314
SGTC_555 4296-0685 37 µM 0.0815054552293969 0.47392124539412 no 1574 0.467519993334749 2267 2908540 YHR072W ERG7
SGTC_2019 4016004 108 µM 0.0812224497651372 0.474026088896501 no 1575 0.467632523083822 2186 45595336
SGTC_2506 ethyl hematommate 54.16 µM 0.079960989600064 0.474493436994907 no 1576 0.468134141186449 2075 3940691 An allergen.
SGTC_2109 5483026 200 µM 0.079915442156674 0.474510312156543 no 1577 0.468152254023245 2187 759335
SGTC_938 3126-1755 342 µM 0.0798147926415452 0.474547602596911 no 1578 0.468192279516503 2266 1777771
SGTC_2405 ticlatone 3.52 µM 0.0795267333261168 0.474654329217849 no 1579 0.468306834414136 2291 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2937 9044753 11.33 µM 0.0795189409198711 0.474657216347101 no 1580 0.468309933320388 2259 6465530 YGL099W LSG1
SGTC_3272 9137413 49.47 µM 0.079431810506561 0.47468949873371 no 1581 0.468344583721395 2276 17614870
SGTC_2839 9003951 25.97 µM 0.0789813966916775 0.474856382636088 no 1582 0.468523710060906 2318 2990634
SGTC_613 3914-0030 117 µM 0.078869181276229 0.474897960526298 no 1583 0.46856833831873 2245 1145395
SGTC_3321 9137793 26.8275 µM 0.0781418088875289 0.475167472079912 no 1584 0.468857625083402 2282 4904192
SGTC_3183 9108214 49.47 µM 0.0781301275595199 0.475171800427512 no 1585 0.468862271055006 2253 4974831
SGTC_266 formosanin C 406 nM 0.0742241233741359 0.47661927506337 no 1586 0.47041602555731 2271 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1780 st038448 24.544 µM 0.0740124583259634 0.476697722210487 no 1587 0.470500236070078 2229 728868 YDL195W SEC31
SGTC_2111 5486399 200 µM 0.0734387590196484 0.476910350764925 no 1588 0.470728487805574 2274 689674
SGTC_854 0422-0053 192 µM 0.0732987268645421 0.476962251487728 no 1589 0.470784202395782 2247 3596728
SGTC_1443 4112-3303 14 µM 0.0732265230018383 0.476989012870147 no 1590 0.470812930368435 2256 704433
SGTC_1207 2099-0101 141 µM 0.0726472147580477 0.477203729359883 no 1591 0.471043427004459 2282 5837381
SGTC_3191 9110352 49.47 µM 0.0725323800496887 0.477246292817604 no 1592 0.471089118884511 2273 17122424
SGTC_652 0437-0092 114 µM 0.0721263476334192 0.477396790715619 no 1593 0.471250679223831 2267 3091274
SGTC_1649 st011737 51.3 µM 0.0717771976821806 0.477526207428856 no 1594 0.471389609809203 2186 1761035
SGTC_2450 5739737 12.93 µM 0.0709940511316334 0.47781649890605 no 1595 0.471701245027482 2198 2262825
SGTC_2359 9039622 200 µM 0.0709212765985367 0.477843475078826 no 1596 0.471730204867564 2232 6463596
SGTC_1719 st032227 49.2 µM 0.0699838819933764 0.478190958944833 no 1597 0.47210324424282 2239 3125804
SGTC_670 4204-0025 119 µM 0.0680763614546228 0.478898110805146 no 1598 0.472862423760053 2246 719039
SGTC_2860 9025725 38.96 µM 0.0678196206951082 0.478993294301791 no 1599 0.472964612332637 2170 40546248
SGTC_2117 5521686 200 µM 0.0677336850329442 0.479025154165425 no 1600 0.472998817048697 2232 803312
SGTC_756 0508-1999 28.3 µM 0.0660860596937616 0.479636021924748 no 1601 0.473654654670507 2201 6753853
SGTC_2863 9028737 58.44 µM 0.0658741496857741 0.47971459243371 no 1602 0.473739010715477 2304 6460917
SGTC_3245 9134821 49.47 µM 0.0654646778809115 0.479866415752686 no 1603 0.47390201447616 2284 17014901
SGTC_261 5-fluorouridine 15.376 µM 0.0652616715713343 0.47994168720084 no 1604 0.473982829456856 2280 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1995 st072814 61.1 µM 0.0647996879567433 0.48011298589655 no 1605 0.474166744952164 2127 5769371
SGTC_3175 9106517 49.47 µM 0.0644137850247504 0.480256077486932 no 1606 0.474320376979724 2229 41468073
SGTC_3117 9124945 49.47 µM 0.0629919894374227 0.480783296620588 no 1607 0.474886441578552 2235 17592065
SGTC_2021 4019055 173 µM 0.0608995511329768 0.481559259123931 no 1608 0.475719603464061 2273 44827708 YER133W GLC7
SGTC_1862 st057513 3.81 µM 0.060746202427347 0.481616129938157 no 1609 0.475780667690612 2280 5393163
SGTC_2569 tetrandrine 100 µM 0.0589954459671292 0.482265440722161 no 1610 0.476477867693817 2182 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3084 9116877 49.47 µM 0.0586104844415196 0.482408219473503 no 1611 0.476631179832012 2315 27241325
SGTC_1849 st056239 19.2 µM 0.0581534437822602 0.482577734652208 no 1612 0.476813202201377 2211 5393181
SGTC_1552 6-methylflavone 10.6 µM 0.0565630706992956 0.483167624198141 no 1613 0.477446626368504 2315 689013
SGTC_3257 9139206 32.98 µM 0.0564771646246146 0.483199488911241 no 1614 0.477480843236858 2291 4910041
SGTC_1607 st000305 50.6 µM 0.056348626045055 0.48324716728772 no 1615 0.477532041179478 2291 5457690
SGTC_1244 0416-0015 52.5 µM 0.0554579704159535 0.483577541683542 no 1616 0.477886806569529 2269 96201
SGTC_2432 5630864 12.22 µM 0.0548476572960696 0.483803934053896 no 1617 0.478129916242747 2256 5714970
SGTC_2820 7989630 71.43 µM 0.053435359186705 0.484327838343443 no 1618 0.478692516444045 2307 2984098
SGTC_1190 1486-1332 13 µM 0.0528526381796266 0.484544011715143 no 1619 0.478924660436243 2289 4150046
SGTC_1205 4161-2785 76 µM 0.05275477470167 0.484580316805168 no 1620 0.478963647924317 2136 3498106
SGTC_1835 st008666 49.2 µM 0.0526712299110053 0.484611310094072 no 1621 0.47899693120001 2224 690455
SGTC_2227 7312221 64.1025 µM 0.052176324744082 0.484794910980015 no 1622 0.479194098674646 2285 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2814 7977482 42.97 µM 0.0488298852783677 0.486036462266235 no 1623 0.480527432783547 2298 6456762
SGTC_674 0498-0004 451 µM 0.0475716927943061 0.486503295703322 no 1624 0.481028796178063 2267 4231473
SGTC_1177 0983-0204 23.6 µM 0.0469668352864049 0.486727725625897 no 1625 0.481269829976488 2323 766818
SGTC_1957 st077035 62.4 µM 0.0463351919514257 0.486962098806631 no 1626 0.48152154514967 2345 705593
SGTC_3095 9117207 49.47 µM 0.0461935061899901 0.487014672360609 no 1627 0.481578009130575 2325 17015229
SGTC_1629 st005085 44.9 µM 0.0460747319865696 0.487058744584759 no 1628 0.481625342783846 2280 24207091
SGTC_529 4076-0302 30.3 µM 0.0458989142152956 0.487123983621889 no 1629 0.481695409798741 2194 5816522
SGTC_470 aa-861 153 µM 0.0438793462480891 0.487873389875976 no 1630 0.482500289373848 2306 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_135 0933-0004 26.348 µM 0.0434708303481208 0.488024984208781 no 1631 0.482663108273741 2281 21230617 YGL099W LSG1
SGTC_1199 1638-0010 4.46 µM 0.0431631491237439 0.488139161397616 no 1632 0.482785740217626 2304 3111136
SGTC_320 4092-0846 5.34 µM 0.0431014932446767 0.48816204134756 no 1633 0.482810314485034 2314 1359356
SGTC_2148 5546263 113.568 µM 0.042323501604855 0.48845075046812 no 1634 0.483120405248901 2300 792097
SGTC_1148 3909-7663 27.7 µM 0.0421207901114442 0.488525976771338 no 1635 0.483201203382296 2332 4084526
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0420786687276504 0.488541608082307 no 1636 0.483217992498198 2340 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_545 4218-0007 221 µM 0.041957342569055 0.488586632506544 no 1637 0.48326635192411 2294 2840508
SGTC_904 1141-0088 396 µM 0.0415331391031434 0.488744056555052 no 1638 0.483435437227152 2265 1378119
SGTC_1405 3909-7894 12 µM 0.0398713686120814 0.489360764637369 no 1639 0.484097838741386 2333 7104060
SGTC_751 0833-0568 350 µM 0.039346240838514 0.489555652830172 no 1640 0.484307170140492 2299 6954252
SGTC_2335 9018011 154.17 µM 0.0390498127764801 0.489665665882244 no 1641 0.484425337011393 2311 6458208
SGTC_2305 7443522 69.23 µM 0.0366370802734968 0.490561129400865 no 1642 0.485387188791661 2315 5415886
SGTC_119 0121-0043 24.815 µM 0.0363590138769166 0.49066433433418 no 1643 0.485498047371294 2342 1092378
SGTC_1574 spiramycin 23.7 µM 0.0362229082105555 0.49071485046941 no 1644 0.485552309931584 2324 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1876 myriocin 605 nM 0.0352180062636716 0.491087828201089 no 1645 0.48595295210755 2343 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2204 7233102 200 µM 0.0348170270249074 0.491236657180327 no 1646 0.486112821630212 2320 2172480
SGTC_2817 7995342 71.43 µM 0.0334944067988182 0.491727574470038 no 1647 0.486640163029502 2333 18879975
SGTC_3194 9111903 49.47 µM 0.0331332016444554 0.491861645289748 no 1648 0.486784183097093 2333 17087251
SGTC_1915 st067105 30.6 µM 0.0320262471631158 0.492272526302447 no 1649 0.487225559710433 2350 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2462 5162487 171.77 µM 0.0308635936232459 0.49270409059509 no 1650 0.487689162081104 2342 2259986
SGTC_3073 9114972 49.47 µM 0.0301263863550025 0.492977738335606 no 1651 0.487983128505173 2356 41905075
SGTC_585 0kpi-0023 191 µM 0.0293958931738382 0.493248897099866 no 1652 0.488274424081689 2352 64601
SGTC_625 k213-0058 121 µM 0.0285978804512124 0.493545122650719 no 1653 0.48859265127467 2310 3655420
SGTC_689 0833-0039 98 µM 0.0281432490282142 0.493713885276131 no 1654 0.488773949992392 2339 5374726
SGTC_2572 astragaloside iv 100 µM 0.0279690179866459 0.493778561457405 no 1655 0.488843430770182 2302 45006101 An anti-inflammatory agent.
SGTC_924 2046-0044 21.3 µM 0.0276943201161048 0.493880532190477 no 1656 0.48895297692919 2363 3623589
SGTC_2648 atorvastatin 78.68 µM 0.0275534088439338 0.493932840089453 no 1657 0.4890091709491 2352 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_93 0109-0045 59.227 µM 0.0271625910469034 0.494077916732798 no 1658 0.489165026354581 2350 88733
SGTC_3231 9132313 49.47 µM 0.0261263145895671 0.494462599756799 no 1659 0.489578294108133 2298 4905967
SGTC_3295 9122362 53.5725 µM 0.0260339104138844 0.494496901976125 no 1660 0.489615145505905 2308 4730473
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0240574615068662 0.495230607412557 no 1661 0.490403387146311 2275 688788
SGTC_1105 epirubicin 18.1 µM 0.0236891947940095 0.495367318743506 no 1662 0.490550262446994 2368 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1200 1643-0193 18.4 µM 0.0235825050338802 0.495406925192556 no 1663 0.490592813615838 2359 5403974
SGTC_1637 st007924 17.4 µM 0.0225540064112901 0.495788737091088 no 1664 0.491003016025665 2367 683336
SGTC_1373 2887-0003 58.5 µM 0.0209705486658023 0.496376575154071 no 1665 0.491634574633852 2340 776948
SGTC_1950 st077106 7.18 µM 0.0209564764257311 0.496381799327063 no 1666 0.49164018741194 2271 13831864
SGTC_1002 4049-0206 172 µM 0.0205570750009229 0.496530073213719 no 1667 0.491799491204873 2369 4662749
SGTC_2033 5192550 145 µM 0.0198668572919424 0.496786310930013 no 1668 0.49207479198703 2364 182073
SGTC_495 decylubiquinone 155 µM 0.0194840677399554 0.496928419019254 no 1669 0.492227473366721 2328 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2293 7624732 200 µM 0.0176833184579413 0.497596940210059 no 1670 0.492945744255243 2366 894453
SGTC_2804 7954240 19.48 µM 0.0170624636528515 0.49782743180931 no 1671 0.493193392107979 2364 828705
SGTC_1731 st035964 63 µM 0.0170118219034774 0.497846232530852 no 1672 0.493213592311044 2281 6739575
SGTC_199 4063-0024 41.6 µM 0.0151821863915297 0.498525486586551 no 1673 0.493943416612895 2366 306215
SGTC_1751 st044839 27.194 µM 0.0147916138345999 0.498670487668421 no 1674 0.494099215020726 2384 5291326
SGTC_2091 4-phenylthiadiazole 200 µM 0.0141030489119491 0.498926119610273 no 1675 0.494373884009056 2374 270010
SGTC_2261 9010538 184.68 µM 0.0125313773736895 0.499509609206831 no 1676 0.495000834575318 2303 6457250
SGTC_1365 1672-3266 55.4 µM 0.0121890627721788 0.499636695108916 no 1677 0.495137387911024 2384 6415873
SGTC_1420 4'-methoxyflavone 42 µM 0.0114982263125161 0.499893171485193 no 1678 0.495412972449083 2388 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1216 1165-0504 9.65 µM 0.0109227267610051 0.499893171485193 no 1679 0.495642549122912 2383 6304004
SGTC_3104 9120930 49.47 µM 0.00979544898814936 0.499474664231616 no 1680 0.496092243735282 2371 17014836
SGTC_2514 salinomycin 42.74 µM 0.00875926466185032 0.49908997635385 no 1681 0.496505603665647 2393 23682228 A polyether potassium ionophore.
SGTC_1361 1608-0041 5.61 µM 0.0084898882512742 0.498989969329566 no 1682 0.496613065308093 2387 X1361
SGTC_813 k007-0158 173 µM 0.00793004491887051 0.498782125558165 no 1683 0.496836402953871 2381 6523916
SGTC_946 3434-1334 87.4 µM 0.00764045182919253 0.498674613249244 no 1684 0.496951930379935 2386 4047976
SGTC_2045 5106652 78.05 µM 0.00758678379380605 0.498654688839405 no 1685 0.496973340207812 2386 673349
SGTC_253 dyclonine 31.25 µM 0.00562232325490439 0.497925380026813 no 1686 0.497757029356452 2392 3180 An oral anasthetic.
SGTC_303 1348-1668 34.2 µM 0.00560731210855574 0.497919807140637 no 1687 0.49776301784301 2390 5380509
SGTC_3314 9135860 59.4275 µM 0.00460929525074313 0.497549294472817 no 1688 0.498161163752825 2397 25252478
SGTC_1091 telmisartan 47.6 µM 0.00313964084408304 0.497003690820467 no 1689 0.498747466579796 2388 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_723 4182-0001 115 µM 0.0031302565465361 0.497000206952338 no 1690 0.498751210354463 2393 744821 YLR208W SEC13
SGTC_2365 9042475 200 µM 0.00262633940509592 0.496813130866722 no 1691 0.498952243373134 2394 6464479
SGTC_2052 5265182 7.135 µM 0.00244132893381361 0.496744447060621 no 1692 0.499026051635404 2400 1239884
SGTC_1041 0206-0046 107 µM 0.00215780418647964 0.49663919072642 no 1693 0.499139161345214 2382 50494
SGTC_929 2805-0021 398 µM 0.00099965806483075 0.496209240588701 no 1694 0.499601194198417 2397 3098024
SGTC_1959 st077091 55.8 µM 0.000149412182013257 0.495893598102757 no 1695 0.49994039316361 2404 821356 YKL052C ASK1
SGTC_912 3474-0017 2.18 µM 0 0.495838131075532 no 1696 0.5 2406 3360550
SGTC_76 0433-0009 400.328 µM -9.92251333161743e-05 0.495801295280323 no 1697 0.499960414899107 2407 2841569
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.000412323135472185 0.495685062728475 no 1698 0.499835506872733 2409 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1872 amphotericin b 148 nM -0.000435198538970106 0.495676570620424 no 1699 0.499826380907916 2408 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_49 0717-0965 32.132 µM -0.000849786699361013 0.495522662095874 no 1700 0.499660984197105 2408 5889349 YGL099W LSG1
SGTC_2165 5727197 32.143 µM -0.00132206569513528 0.495347337681962 no 1701 0.499472572250387 2414 1361712
SGTC_432 NS 1619 61.3 µM -0.00170602904453742 0.495204799399 no 1702 0.499319393212696 2430 4552 A K+/calcium channel activator.
SGTC_1104 tacrolimus 29.8 µM -0.00233230292202583 0.494972309772668 no 1703 0.499069546597255 2412 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1024 4507-0395 26 µM -0.00267269836032823 0.49484594658613 no 1704 0.498933748890734 2430 4201836
SGTC_308 4092-1169 104 µM -0.00544670834000762 0.493816186034322 no 1705 0.497827088497989 2410 2268590 YDL196W YDL196W
SGTC_1193 1488-0126 41.5 µM -0.00717567819033493 0.49317438288841 no 1706 0.497137343145879 2424 1384710
SGTC_149 3970-0822 46.1 µM -0.00771421920510807 0.492974477023916 no 1707 0.496922502322054 2425 3114250 YBL034C STU1
SGTC_2985 9022375 71.43 µM -0.0078884682397316 0.492909796338892 no 1708 0.496852989130264 2486 4939335
SGTC_3021 9087658 49.47 µM -0.0090640099766503 0.492473443957371 no 1709 0.496384032702803 2420 25237042
SGTC_988 1497-1057 103 µM -0.0091115183372231 0.492455809391816 no 1710 0.496365080391728 2423 3533044
SGTC_2593 nobiletin 86.24 µM -0.00946320452573451 0.49232526792128 no 1711 0.496224783953191 2429 72344 An anti-infammatory.
SGTC_1042 0350-0096 82 µM -0.0108701315572385 0.491803042741269 no 1712 0.495663530327829 2424 3122515
SGTC_2089 5281248 129.67 µM -0.0109451150947505 0.491775210631403 no 1713 0.49563361800387 2434 2737878
SGTC_406 estrone 100 µM -0.0118807049988347 0.491427945269614 no 1714 0.495260395955345 2424 5870 A steroid.
SGTC_2086 5274770 176.623 µM -0.0123156230217059 0.491266517800964 no 1715 0.495086901466155 2432 689278
SGTC_1708 st033234 31.827 µM -0.0124368743782536 0.49122151348262 no 1716 0.495038532877989 2458 674664
SGTC_3116 9124943 49.47 µM -0.0132155943636847 0.490932482191111 no 1717 0.494727894112053 2435 41905195 YPL160W CDC60
SGTC_2407 paclitaxel 400 µM -0.0142162051592749 0.490561100466193 no 1718 0.494328745722958 2537 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_881 0833-0569 170 µM -0.0144654825317966 0.49046858117739 no 1719 0.494229308665398 2427 5418700
SGTC_622 1348-1566 26.3 µM -0.0162585026471849 0.489803117232121 no 1720 0.493514081626042 2450 7340407
SGTC_19 0279-0214 38.434 µM -0.0163321717056166 0.489775776191108 no 1721 0.493484695825665 2441 3566274 YBR002C RER2
SGTC_753 1322-0200 289 µM -0.0166280988612461 0.489665948253688 no 1722 0.493366654002661 2470 5403907
SGTC_3221 9128209 49.47 µM -0.017058924298972 0.489506056695482 no 1723 0.493194803900408 2446 16460723
SGTC_3158 9100007 49.47 µM -0.0179112512895388 0.489189738930693 no 1724 0.492854826611744 2443 19297233
SGTC_1594 piperine 70.1 µM -0.0179579157216934 0.489172420902225 no 1725 0.492836213190506 2435 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1121 fusaric acid 630.51 nM -0.0198293359232493 0.488477919644284 no 1726 0.492089757899241 2459 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_588 3970-1144 52.9 µM -0.0200135623304896 0.488409553383958 no 1727 0.492016276778788 2467 1888707
SGTC_2697 mebhydrolin 72.4 µM -0.0212601611713615 0.487946950683357 no 1728 0.491519061714918 2449 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1320 1313-0481 95.3 µM -0.0243925050358783 0.486784636275623 no 1729 0.490269763331746 2454 6813365 YLR208W SEC13
SGTC_3301 9125354 19.7965 µM -0.0248383820288838 0.486619194227462 no 1730 0.490091938030971 2460 41905162
SGTC_2251 lansoprazole 556 µM -0.0251085453393903 0.486518951619356 no 1731 0.489984192068535 2463 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2720 fluspirilene 36.88 µM -0.0265183133139547 0.485995878942279 no 1732 0.489421963411467 2473 3396 An atypical antipsychotic.
SGTC_2231 micatex 6.853 µM -0.0266050486447547 0.485963697912287 no 1733 0.489387373225053 2478 20737 An antifungal of unknown mechanism.
SGTC_2735 sertaconazole 140 nM -0.028677646543845 0.485194738654146 no 1734 0.488560842254091 2455 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2988 9073640 71.4286 µM -0.0297572688064482 0.484794207170656 no 1735 0.488130319106957 2501 9102229
SGTC_1991 st073000 8.92 µM -0.0297758713632457 0.484787305899697 no 1736 0.488122901047636 2485 4301969 YIL048W NEO1
SGTC_2866 9034245 58.44 µM -0.0323012492157436 0.483850471563514 no 1737 0.487115906497951 2530 6462273
SGTC_2470 5664817 21.68 µM -0.0333210984760356 0.483472165115772 no 1738 0.486709264474859 2457 2859561
SGTC_1438 4092-1045 4 µM -0.0339803112746386 0.483227642312656 no 1739 0.486446425480095 2472 1351342
SGTC_928 2764-0428 58.7 µM -0.0340139950287681 0.483215148115276 no 1740 0.486432995369958 2566 662578
SGTC_325 2810-4341 181 µM -0.0348071915118212 0.482920935302379 no 1741 0.486116743055357 2471 774970
SGTC_180 1486-1293 102.781 µM -0.0356534165857587 0.482607063356953 no 1742 0.485779357546785 2478 4140536
SGTC_3026 9090633 49.47 µM -0.0360276668303284 0.482468254242763 no 1743 0.485630149164825 2469 25236842
SGTC_1969 st069479 40.1 µM -0.0363028113371836 0.482366204721429 no 1744 0.485520454148029 2482 3895485
SGTC_2185 6113692 200 µM -0.0363605633388798 0.482344784981329 no 1745 0.485497429633875 2519 874150
SGTC_2496 diffractaic acid 79.83 µM -0.036694710887485 0.482220853419722 no 1746 0.485364212952511 2465 94870 An apoptosis inducer which activates caspases.
SGTC_692 k241-0027 77.8 µM -0.0369169529366544 0.482138427297813 no 1747 0.485275611236136 2501 3600480
SGTC_208 k072-0098 12.366 µM -0.0372059563465262 0.482031241567337 no 1748 0.485160394712247 2485 5948901
SGTC_1456 k015-0012 13 µM -0.0373101411002081 0.481992601791429 no 1749 0.48511885984762 2469 2989616
SGTC_1108 betulinic acid 729.144 nM -0.0376212902325464 0.481877204602655 no 1750 0.484994816392927 2484 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0385762160086229 0.481523056781932 no 1751 0.484614132525111 2458 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2702 st077768 96.8 µM -0.0393626237433854 0.481231417212155 no 1752 0.48430063936636 2521 6484119
SGTC_1529 apigenin 74 µM -0.0398173423307758 0.481062789246058 no 1753 0.484119375007268 2502 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_327 1273-0057 3.96 µM -0.0399714100019045 0.481005655515516 no 1754 0.484057959791763 2473 3108138
SGTC_848 0368-0089 85.6 µM -0.0402510149966688 0.48090196911167 no 1755 0.483946503235725 2485 762535
SGTC_1000 4048-0884 8.67 µM -0.040380636942513 0.480853901619181 no 1756 0.483894833569219 2522 13040088
SGTC_1329 1447-1697 50.6 µM -0.0405549398085391 0.480789265613691 no 1757 0.483825353701323 2564 2840515
SGTC_1307 1187-1599 12.2 µM -0.0416598974064342 0.480379530611417 no 1758 0.483384911710926 2491 1538471
SGTC_282 k297-0036 65.7 µM -0.0420119734231579 0.480248979829375 no 1759 0.483244576566893 2506 5061378
SGTC_771 0250-0039 27.3 µM -0.0445267523484686 0.479316555136515 no 1760 0.4822422639147 2482 3005115
SGTC_42 0133-0086 60.653 µM -0.04507754847726 0.479112346982936 no 1761 0.482022748473689 2493 162923 Model of phenazepam hydroxylation.
SGTC_2065 5221596 34.26 µM -0.0451919538259154 0.479069931784295 no 1762 0.481977153808181 2542 788581
SGTC_1906 st060206 94.7 µM -0.045977532793367 0.478778688821741 no 1763 0.481664078600812 2475 5133468
SGTC_553 k007-0256 45.7 µM -0.0462828734740528 0.478665490871514 no 1764 0.481542394833998 2512 6287000
SGTC_417 st075190 100 µM -0.0464516011600295 0.478602939746903 no 1765 0.481475154545774 2471 222757
SGTC_3052 9092717 49.47 µM -0.0471921887111437 0.478328393641922 no 1766 0.481180026546458 2555 25237534
SGTC_1273 0849-0096 14.1 µM -0.0480988429242606 0.477992298329906 no 1767 0.480818734176357 2509 5286025
SGTC_1137 ixabepilone 100 µM -0.0487218774221939 0.477761349465279 no 1768 0.48057047045833 2486 154225 A novel microtubule stabilizer.
SGTC_2886 9058944 51.95 µM -0.0487855828207732 0.477737735318496 no 1769 0.480545085867934 2483 4949929
SGTC_2981 9013952 38.96 µM -0.0488139370538953 0.477727225072318 no 1770 0.480533787626436 2537 2996344
SGTC_438 sphingosine 6.67 µM -0.0497615396834796 0.477375980058824 no 1771 0.480156207789021 2512 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_108 0509-0257 621.132 µM -0.0502043416582204 0.477211853992425 no 1772 0.47997977588801 2502 536624
SGTC_2649 anisomycin 9.56 µM -0.0547978447323679 0.475509489513761 no 1773 0.478149758739435 2532 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2390 9097792 176.6 µM -0.0566650291062116 0.474817632021847 no 1774 0.47740601598254 2528 4497149
SGTC_761 k216-0224 480 µM -0.0568375812052591 0.474753699200286 no 1775 0.477337288419701 2504 1340404
SGTC_329 k048-0121 21.3 µM -0.0578922265298055 0.474362953430638 no 1776 0.476917237534731 2561 6832902
SGTC_3278 9139605 49.47 µM -0.059547723877703 0.473749642051476 no 1777 0.476257927365529 2693 7958859
SGTC_2734 clemastine 41.6 µM -0.0599504970313911 0.473600436211375 no 1778 0.47609753068643 2515 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0604323021272642 0.473421958144231 no 1779 0.475905666142682 2489 4620898
SGTC_1583 clindamycin 39.6 µM -0.0612666708157731 0.473112890386378 no 1780 0.475573416877775 2525 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2837 9008476 45.46 µM -0.0624336483497994 0.472680644488906 no 1781 0.475108749854454 2612 2992805
SGTC_215 1287-0124 461.5 µM -0.0624761527716939 0.472664901549153 no 1782 0.475091826082222 2595 5560863
SGTC_1870 st057514 26.5 µM -0.0629219631029508 0.472499783302038 no 1783 0.474914322734713 2506 5393161
SGTC_1218 1348-1416 30.7 µM -0.0639910133881697 0.472103850122831 no 1784 0.474488691210289 2509 6787668
SGTC_1557 sumaresinolic acid 42.3 µM -0.0642585568746662 0.472004767085549 no 1785 0.474382176021868 2495 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2787 5284540 71.43 µM -0.0648242578889067 0.47179526900658 no 1786 0.474156963532862 2572 736958
SGTC_1713 st033146 12.748 µM -0.0652652248616359 0.471631969540501 no 1787 0.473981414914822 2537 674619
SGTC_445 e6 berbamine 66 µM -0.0664183999494136 0.471204946846423 no 1788 0.473522360753172 2588 6610268 A calcium/calmodulin antagonist.
SGTC_2949 9072542 2.23 µM -0.0668223109535597 0.47105538571842 no 1789 0.473361580766007 2585 16457352
SGTC_120 rhodamine 6G 52.259 µM -0.06685665212068 0.471042669977319 no 1790 0.473347911191138 2533 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_15 0266-0086 27.098 µM -0.0671298609582452 0.470941508107105 no 1791 0.473239160949601 2523 1712902 YIL048W NEO1
SGTC_2741 miltefosine 3.04 µM -0.0673037775278914 0.470877112464313 no 1792 0.47316993483884 2543 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1689 st020265 53.493 µM -0.0685042265350988 0.470432646143476 no 1793 0.472692127846734 2538 5758320 YPR016C TIF6
SGTC_807 1315-0151 48 µM -0.0688440292620729 0.47030684082688 no 1794 0.472556885459634 2525 4011080
SGTC_1078 idebenone 36.1 µM -0.0706114428584196 0.469652538574195 no 1795 0.471853501531754 2595 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2605 digitonin 300 nM -0.0710892850701121 0.469475653833311 no 1796 0.471663347935441 2529 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_122 0236-0016 402.397 µM -0.0722585202972647 0.469042858881152 no 1797 0.471198087186878 2536 6808838
SGTC_132 0417-1715 25.805 µM -0.0723231186083759 0.469018948737934 no 1798 0.47117238344057 2548 6769098
SGTC_685 1278-0033 54.9 µM -0.0730383005594764 0.46875424182796 no 1799 0.470887819723462 2533 3590572
SGTC_2428 5615643 7.78 µM -0.0732528413822199 0.468674837536685 no 1800 0.470802458975987 2586 2253075
SGTC_3224 9130643 49.47 µM -0.0733302140091401 0.468646201247468 no 1801 0.470771674556437 2621 17644395
SGTC_37 0566-0070 1.56 µM -0.0743518939654582 0.468268083786067 no 1802 0.470365192925205 2603 1626686
SGTC_1925 st057770 10.1 µM -0.0747249521071593 0.468130024380951 no 1803 0.470216777130834 2539 5989122
SGTC_1475 4092-1048 11.7 µM -0.0753008607762192 0.46791690264577 no 1804 0.469987668314211 2576 2881759
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0763611146659526 0.467524567391829 no 1805 0.469565902622081 2604 71034 A hepatoprotective.
SGTC_2644 guaiazulene 100 µM -0.0771984122004995 0.467214756951025 no 1806 0.469232852379774 2587 3515 A coloring agent.
SGTC_2797 7859098 81.82 µM -0.0805244129104182 0.465984293524338 no 1807 0.467910090291169 2571 972681
SGTC_1236 0330-0013 258 µM -0.080879155480354 0.465853074480758 no 1808 0.467769028582622 2581 4617066
SGTC_1171 0368-0077 21.4 µM -0.0812538080066712 0.465714494788319 no 1809 0.467620054168532 2563 3239779
SGTC_1473 k844-0725 134 µM -0.0822356174006853 0.465351354467441 no 1810 0.467229675381095 2556 54682906
SGTC_2520 obtusaquinone 4.71 µM -0.0823549541302551 0.465307217536533 no 1811 0.46718222785595 2626 5967872
SGTC_105 0111-0055 734.78 µM -0.0828886964634952 0.46510981708537 no 1812 0.466970021013173 2635 5179370
SGTC_2369 9071472 200 µM -0.0830970152515218 0.465032774328459 no 1813 0.466887199562073 2661 17296037
SGTC_1383 3049-0032 20.7 µM -0.0836279013247106 0.464836442105855 no 1814 0.466676141292979 2636 712864
SGTC_3189 9110682 49.47 µM -0.0857857453936594 0.464038517086511 no 1815 0.465818369115158 2625 17122418
SGTC_2522 biochanin a 4.94 µM -0.0874394523173315 0.463427109018402 no 1816 0.465161105518896 2609 5280373 A possible chelator.
SGTC_2808 7946468 45.46 µM -0.0875830669452366 0.463374015913343 no 1817 0.465104030537143 2623 2970879
SGTC_2282 7944268 200 µM -0.0880323205458763 0.463207934899088 no 1818 0.464925493886956 2626 2970414
SGTC_3064 1327-0027 10 µM -0.0910758651993609 0.462082961256029 no 1819 0.463716154853822 2571 16000455 YPR107C YTH1
SGTC_293 4049-0273 38.5 µM -0.0915352764509278 0.46191317697371 no 1820 0.463533638662936 2580 1380311
SGTC_1600 coumarin 106 71.1 µM -0.0925631347337759 0.461533337315514 no 1821 0.463125316093098 2724 100336 A hepatotoxic, DNA x-linker.
SGTC_212 3807-4682 38.772 µM -0.0935564247869687 0.461166305497466 no 1822 0.462730762854208 2643 3125501 YBL034C STU1
SGTC_780 0109-0199 192 µM -0.0936077802786096 0.461147329963749 no 1823 0.46271036449355 2680 610414
SGTC_161 4065-0411 162.148 µM -0.0965295092416564 0.460067916334316 no 1824 0.461550019182919 2674 1906281 YLR208W SEC13
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0979769055341219 0.459533293740497 no 1825 0.460975315917143 2574 229346 A bile salt which induces apoptosis.
SGTC_2140 5586273 200 µM -0.0989882888729294 0.459159763963293 no 1826 0.460573784279568 2571 854421
SGTC_1804 st050076 49.1 µM -0.0992337490772152 0.45906911464558 no 1827 0.460476339602654 2665 3895976
SGTC_2095 5432005 200 µM -0.0995606988314759 0.458948374256187 no 1828 0.460346548265678 2620 783734
SGTC_1055 3448-0672 86 µM -0.100153845916236 0.458729338621528 no 1829 0.460111093664606 2703 748378
SGTC_1382 3002-2117 298 µM -0.101009987461526 0.458413207266997 no 1830 0.459771265940734 2617 1497314
SGTC_1285 0929-0069 65.5 µM -0.101625430449679 0.458185970398968 no 1831 0.459526996684373 2620 1206237
SGTC_1736 st036774 51 µM -0.102463396054855 0.457876594627167 no 1832 0.459194432804221 2831 1272247
SGTC_2829 7992743 58.44 µM -0.102864213645129 0.457728622324484 no 1833 0.459035370183058 2649 16462845
SGTC_803 4488-1585 147 µM -0.103685260195155 0.457425529819903 no 1834 0.458709562131066 2631 747204
SGTC_731 3966-0296 387 µM -0.103896785262449 0.457347448528611 no 1835 0.458625629145488 2597 660956
SGTC_3137 9097352 49.47 µM -0.104328525451171 0.457188083256346 no 1836 0.458454320696146 2780 44120435
SGTC_2322 7413319 38.22 µM -0.105599255123032 0.45671906763974 no 1837 0.457950157886781 2696 1840400
SGTC_2772 vinpocetine 57.06 µM -0.106786816464198 0.456280803237087 no 1838 0.45747905330161 2685 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_705 1124-0212 310 µM -0.107375724860222 0.456063488820157 no 1839 0.457245455953125 2586 9554485
SGTC_3217 9129673 49.47 µM -0.107399807558019 0.456054602288742 no 1840 0.457235903585434 2709 17248312
SGTC_1012 4112-3522 18 µM -0.108304912283442 0.455720634023843 no 1841 0.456876913050522 2594 3112398
SGTC_2101 5377231 179.231 µM -0.109021042536085 0.455456416285759 no 1842 0.456592900141377 2683 2844213
SGTC_2826 7992541 19.48 µM -0.109034414156626 0.4554514829857 no 1843 0.456587597248301 2578 2985066
SGTC_382 3229-0966 23.2 µM -0.109112835009575 0.455422550684787 no 1844 0.456556497404017 2711 5722370
SGTC_2798 7813637 45.45 µM -0.110874337282023 0.454772731103551 no 1845 0.45585799799514 2693 956368
SGTC_2078 5212016 200 µM -0.11175584655577 0.454447586958517 no 1846 0.4555084987394 2569 1899708
SGTC_2507 purpurin 79.67 µM -0.112095132477379 0.454322449680704 no 1847 0.455373988411571 2587 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1370 2001-0092 44.6 µM -0.112359316749392 0.454225014940329 no 1848 0.45526925576827 2663 790957
SGTC_2046 4110841 106 µM -0.112375206068681 0.454219154831766 no 1849 0.455262956739823 2643 44119630 YMR134W ERG29
SGTC_1521 st012942 49.4 µM -0.113404737259649 0.453839476759382 no 1850 0.454854842076061 2857 24207259
SGTC_20 0481-0013 4.944 µM -0.114101675275553 0.453582478761833 no 1851 0.454578597110675 2603 182045
SGTC_511 blebbistatin 171 µM -0.114135960574425 0.453569836455096 no 1852 0.454565008030085 2753 3476986 A myosin inhibitor.
SGTC_2588 indole-3-carbinol 100 µM -0.114161040399471 0.453560588589976 no 1853 0.454555067600211 2703 3712 Induces cell cycle arrest.
SGTC_3196 9111891 49.47 µM -0.114514849727086 0.45343012860568 no 1854 0.454414837727465 2562 18891510
SGTC_1249 0481-0015 10.2 µM -0.114594649743689 0.453400704668747 no 1855 0.45438321032904 2619 4227577
SGTC_276 colchicine 750 µM -0.116450661908484 0.452716426624262 no 1856 0.453647693036669 2727 2833 A microtubule depolymerizer.
SGTC_1212 0520-0165 585 µM -0.117194582275636 0.452442195969636 no 1857 0.453352930026758 2954 5403258
SGTC_3238 9133470 49.47 µM -0.117573675595122 0.452302459878375 no 1858 0.45320273203867 2707 3534688
SGTC_1836 st055642 81 µM -0.118358214724862 0.452013292792363 no 1859 0.452891916408019 2629 8571
SGTC_3256 9138902 49.47 µM -0.118745067699214 0.451870715068651 no 1860 0.452738665128434 2588 17228773
SGTC_700 3453-2283 142 µM -0.118853787643957 0.451830646589636 no 1861 0.452695597136447 2754 565664
SGTC_2393 9031399 185.94 µM -0.119193696300696 0.451705377223494 no 1862 0.452560950335413 2716 1526623 YDL150W RPC53
SGTC_1359 1582-0056 520 nM -0.119904973434474 0.451443259915245 no 1863 0.452279212336157 2719 3661189
SGTC_2389 9091542 195.52 µM -0.120238491600637 0.451320360275451 no 1864 0.452147113528308 2684 3626624 YOL127W RPL25
SGTC_2663 amphotericin b 100 µM -0.12028675105029 0.451302577315504 no 1865 0.452127999518309 2626 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2564 betulinic acid 100 µM -0.122221385520615 0.450589771327072 no 1866 0.451361845113723 2751 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_707 0865-0008 204 µM -0.122640763251933 0.450435274722375 no 1867 0.451195786836206 2638 723043
SGTC_145 3737-0113 38.366 µM -0.122647667363991 0.450432731345687 no 1868 0.451193053131158 2729 6849351
SGTC_538 2922-0838 53.3 µM -0.124422520104052 0.449778968655077 no 1869 0.450490371713971 2617 777039
SGTC_2685 mycophenolic acid 18.85 µM -0.124719668879357 0.449669527896634 no 1870 0.450372742735025 2676 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_60 0986-0278 202 µM -0.125215145629028 0.449487050885628 no 1871 0.450176613567533 2624 3110598
SGTC_1505 k297-0037 20.6 µM -0.126505505867965 0.449011879865046 no 1872 0.449665895505068 2654 4089396
SGTC_595 3909-8003 73.7 µM -0.126846058524872 0.448886484608999 no 1873 0.449531120353679 2720 699517
SGTC_3214 9129694 49.47 µM -0.129226059089399 0.448010285278823 no 1874 0.448589388457933 2709 17158655
SGTC_2716 st080858 38.6235 µM -0.129706866560453 0.447833306232293 no 1875 0.448399174868302 2696 5296050
SGTC_2543 pimpinellin 60.67 µM -0.130422920191862 0.447569755358127 no 1876 0.448115916887338 2625 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_735 3076-0345 636 µM -0.130706171878956 0.447465508055683 no 1877 0.448003874890894 2737 2888990
SGTC_1357 1503-1303 39.5 µM -0.130743595970658 0.44745173484991 no 1878 0.447989071864747 2657 292895
SGTC_2899 9053889 58.44 µM -0.132335922830362 0.446865768975491 no 1879 0.447359297459693 2639 6470052
SGTC_2308 7584454 197.62 µM -0.132686721900805 0.446736692756688 no 1880 0.447220572197372 2721 893577
SGTC_1993 st073995 70.8 µM -0.133760798792536 0.446341522224373 no 1881 0.446795863294124 2681 3098394
SGTC_1625 st003711 30.1 µM -0.134365330203097 0.446119128597925 no 1882 0.446556847740165 2783 24207034 YER133W GLC7
SGTC_412 gemfibrozil 100 µM -0.135768103013859 0.44560314516986 no 1883 0.446002303818421 2654 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_850 0388-0143 75.9 µM -0.135790838387844 0.445594783149153 no 1884 0.445993316940799 2671 67273
SGTC_2755 lomerizine 42.69 µM -0.135802250799582 0.445590585698259 no 1885 0.445988805833573 2693 3949 A calcium channel blocker.
SGTC_602 3130-1533 38.1 µM -0.13738652670861 0.445007953154184 no 1886 0.445362640095824 2752 720941
SGTC_66 0109-0187 42.4 µM -0.137600653362593 0.444929215123064 no 1887 0.445278019566357 2606 759417
SGTC_3260 9137109 49.47 µM -0.137820443257984 0.444848396880998 no 1888 0.445191163578395 2693 17478346
SGTC_337 1315-0038 354 µM -0.13968146984516 0.444164176942285 no 1889 0.444455833889962 2682 1626437
SGTC_3312 9133330 71.43 µM -0.140709512521909 0.443786280796118 no 1890 0.444049714981279 2803 17617324
SGTC_1501 4491-0275 38.4 µM -0.141497368517368 0.443496708964962 no 1891 0.443738519373849 2650 5104718
SGTC_844 0330-0132 15.3 µM -0.141500216236501 0.443495662357195 no 1892 0.443737394614746 2764 2828079
SGTC_1500 4488-1866 171 µM -0.142243489513915 0.443222504398836 no 1893 0.443443840672279 2798 2900003
SGTC_2057 5236571 38.335 µM -0.14287895853745 0.442988986622349 no 1894 0.443192888356276 2739 54684039 YBR257W POP4
SGTC_1767 st044992 70.3 µM -0.145119561480978 0.442165783827706 no 1895 0.442308236974629 2703 9600693
SGTC_1860 st056228 74.6 µM -0.146327103532834 0.441722233350879 no 1896 0.441831585304423 2782 688679
SGTC_418 lividomycin a 100 µM -0.14678021807163 0.441555815593682 no 1897 0.441652749621951 2684 72394 An antibiotic.
SGTC_2439 5492030 7.2 µM -0.150188124779092 0.440304508401922 no 1898 0.440308097340276 2768 5722370
SGTC_2130 NSC 7 2.4545 µM -0.150400769752986 0.440226449543089 no 1899 0.440224217001877 2758 21448
SGTC_123 0083-0120 66.675 µM -0.150465562795744 0.440202665426669 no 1900 0.440198659148798 2678 16001701
SGTC_2411 st077133 39.94 µM -0.151377034632612 0.439868106850396 no 1901 0.439839152198633 2985 1403142 YNL221C POP1
SGTC_3048 9093155 49.47 µM -0.152743141123814 0.43936675367871 no 1902 0.439300419109857 2678 25236002
SGTC_2864 9034755 47.6 µM -0.15285916168564 0.439324179272968 no 1903 0.439254670802068 2657 4930451
SGTC_3130 9127414 49.47 µM -0.154659205930504 0.438663733002609 no 1904 0.438544995946145 2661 1494646
SGTC_2957 9076800 11.52 µM -0.156403668773458 0.438023842761715 no 1905 0.437857422750735 2732 16459615
SGTC_2732 terfenadine 20 µM -0.156638751387978 0.437937623943472 no 1906 0.437764780155887 2674 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2657 nystatin 74.44 µM -0.157071361212484 0.437778967816552 no 1907 0.437594303916517 2725 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_783 0848-0141 92.7 µM -0.157333390397408 0.437682875611115 no 1908 0.437491053108161 2671 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_335 4077-0256 27.6 µM -0.157758418192142 0.4375270158366 no 1909 0.43732358286719 2783 3121989
SGTC_1813 st051246 8.6015 µM -0.157960039531445 0.437453083692019 no 1910 0.437244143577567 2706 5291959
SGTC_2321 7390090 138.78 µM -0.158047144732156 0.437421143927384 no 1911 0.437209824702694 2775 649046
SGTC_1653 st012112 65 µM -0.158073574075095 0.437411452887551 no 1912 0.437199411809214 2836 720429
SGTC_2518 prenyletin 46.28 µM -0.15837293916409 0.437301685130945 no 1913 0.437081468034474 2741 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1477 0139-0234 16 µM -0.158944438520041 0.437092147710263 no 1914 0.436856324412141 2668 620880
SGTC_229 benomyl 22.8748 µM -0.159863765377413 0.436755118098273 no 1915 0.436494196200804 2758 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_128 0906-2981 13.371 µM -0.160649373932374 0.436467146616206 no 1916 0.436184782566409 2809 6740226
SGTC_2000 st075254 36.4 µM -0.161243690559585 0.43624931717506 no 1917 0.435950735606376 2710 17234175
SGTC_542 3381-0244 89.3 µM -0.162039072519131 0.435957823358179 no 1918 0.435637542509094 2863 1112843
SGTC_2882 9058044 58.44 µM -0.162233321409863 0.435886639757354 no 1919 0.435561060336874 2780 18076804
SGTC_699 0375-0592 111 µM -0.163267882092995 0.435507554206266 no 1920 0.435153760465422 2707 762578
SGTC_1349 flufenamic acid 69 µM -0.163614045299492 0.435380725686701 no 1921 0.435017493581229 2688 3371 A non-steroidal anti-inflammatory.
SGTC_1531 st059297 52.4 µM -0.164381360953564 0.435099617534589 no 1922 0.434715467891198 2814 7566702
SGTC_1654 st012436 41.8 µM -0.167078647719654 0.434111720493863 no 1923 0.433654083249851 2724 4323132
SGTC_952 1185-0122 232 µM -0.16761620633081 0.433914885475871 no 1924 0.433442610389057 2661 678600
SGTC_3005 9076496 71.4286 µM -0.167952845578866 0.433791628388236 no 1925 0.433310187896152 2759 21368410
SGTC_2537 larixol 68.93 µM -0.169413395851277 0.433256937249077 no 1926 0.432735743718668 2674 6708759
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.170273766368792 0.432942022320027 no 1927 0.432397420689526 2823 6708739 YPR165W RHO1
SGTC_372 0155-0182 15.9 µM -0.171001263560798 0.432675775228314 no 1928 0.43211138602621 2713 771486
SGTC_2992 9074591 71.4286 µM -0.171517919923986 0.432486709540601 no 1929 0.431908270581419 2734 17741321
SGTC_416 estradiol valerate 100 µM -0.171595627918366 0.432458274344434 no 1930 0.431877722443157 2775 13791 A steroid.
SGTC_720 r052-1644 49.9 µM -0.171801382705088 0.432382985483053 no 1931 0.431796839223581 2823 1422863 YOR257W CDC31
SGTC_429 1112-0049 25.5 µM -0.172000226969041 0.432310227621735 no 1932 0.43171867528115 2726 2836170
SGTC_2620 irigenin 100 µM -0.172316066686792 0.432194665405018 no 1933 0.431594526944792 2867 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_223 busulfan 5 mM -0.173462443174284 0.431775267892244 no 1934 0.431143973171782 2811 2478 A DNA alkylator.
SGTC_2223 6903751 107.57 µM -0.173642286401537 0.431709479891227 no 1935 0.431073298534914 2817 5598863
SGTC_3028 9087778 49.47 µM -0.173878650943625 0.431623018850164 no 1936 0.430980415557131 2718 17217395
SGTC_3346 9158254 43.5805 µM -0.174616762056272 0.4313530423712 no 1937 0.430690388364701 2813 17639500
SGTC_874 0599-0792 117 µM -0.176298414393909 0.430738069866257 no 1938 0.430029753827397 2803 765305
SGTC_3135 9127742 49.47 µM -0.176654649490364 0.430607817837303 no 1939 0.429889832491995 2798 3643468
SGTC_2107 5363541 170.161 µM -0.179307840555182 0.429637956670266 no 1940 0.42884799537656 2727 244052
SGTC_3345 9148410 3.559 µM -0.179489420907083 0.429571596304468 no 1941 0.428776711668914 2830 4903596
SGTC_2391 6285546 200 µM -0.180083235876071 0.429354594556419 no 1942 0.428543611642011 2694 846083
SGTC_2854 9024559 71.43 µM -0.180453136435264 0.429219430124186 no 1943 0.428398421041956 2812 3163529
SGTC_1308 1187-1617 41.4 µM -0.181249271031713 0.428928544756657 no 1944 0.428085961146978 2698 2882570
SGTC_1540 guanosine 70.6 µM -0.182367602546429 0.428520002847142 no 1945 0.427647124431611 2707 6802 Guanosine is a purine nucleoside
SGTC_1181 1222-0449 220 µM -0.183027894225948 0.428278825130374 no 1946 0.427388065935045 2903 658318
SGTC_1046 2001-0062 216 µM -0.183322711527798 0.428171148995843 no 1947 0.427272407570062 2698 739778
SGTC_2199 6590217 200 µM -0.18563824946082 0.42732563155935 no 1948 0.426364228080173 2786 703109
SGTC_2813 7971799 71.43 µM -0.188303602774996 0.42635279257757 no 1949 0.425319330634971 2861 2234054
SGTC_2010 4012422 159 µM -0.188601087517614 0.426244239998117 no 1950 0.425202740197589 2825 952393
SGTC_1347 1493-0251 600 nM -0.18866740995083 0.42622003961522 no 1951 0.425176747952547 2868 3986378
SGTC_2479 5617353 43.85 µM -0.190311069446075 0.425620373930115 no 1952 0.42453269000239 2895 2731746
SGTC_2288 7946289 167.31 µM -0.190510844236217 0.425547500647422 no 1953 0.42445442316491 2902 1246052
SGTC_690 glyoxal 20.3 µM -0.190591105980139 0.425518223711562 no 1954 0.424422979431033 2748 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3141 9094609 49.47 µM -0.191213135560234 0.4252913410062 no 1955 0.424179306400111 2727 25236309 YDL196W YDL196W
SGTC_2894 9048625 32.47 µM -0.191835824572004 0.4250642425538 no 1956 0.423935404071246 2872 4092861
SGTC_2771 fluoxetine 41.05 µM -0.192645833429376 0.424768864640116 no 1957 0.423618173661356 2924 3386 A selective serotonin reuptake inhibitor.
SGTC_671 0560-0003 407 µM -0.193020786017278 0.424632148681498 no 1958 0.423471344652569 2814 3238678
SGTC_964 1287-0107 19.4 µM -0.193072942359616 0.424613132050093 no 1959 0.423450921407586 2885 51516812 YPR165W RHO1
SGTC_2560 caryophyllene 100 µM -0.193331750513312 0.424518771065007 no 1960 0.423349581026685 2733 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_801 0866-0028 10.1 µM -0.193774622445277 0.424357310796506 no 1961 0.423176179359921 2736 6849771
SGTC_2386 9075165 157.42 µM -0.194446290513474 0.424112461288008 no 1962 0.422913223473359 2740 16452277
SGTC_3216 9129716 49.47 µM -0.195018892808235 0.423903748285778 no 1963 0.422689078630499 2799 8056934
SGTC_1921 5740136 50 µM -0.196047575832929 0.423528847933947 no 1964 0.422286464162963 2895 1774243
SGTC_1231 0242-0792 125 µM -0.197123709470496 0.423136728434698 no 1965 0.421865364980198 2735 3707635
SGTC_1416 3966-0321 25.3 µM -0.197969696859048 0.422828522608124 no 1966 0.42153438643984 2814 582530 YLR208W SEC13
SGTC_2691 st077356 60.2 µM -0.198128348028768 0.422770728873705 no 1967 0.421472322964999 2924 2839272
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.198864768116527 0.422502486219398 no 1968 0.421184264999027 2776 689007
SGTC_2417 cerulenin 830 nM -0.201838061694006 0.42141982411369 no 1969 0.420021662465431 2727 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_727 3032-0951 202 µM -0.202198412089975 0.42128865030523 no 1970 0.419880807230858 2835 3652836
SGTC_3181 9108277 49.47 µM -0.202578127586145 0.421150436716353 no 1971 0.41973239359191 2778 17097298
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.203343180028309 0.420871992899795 no 1972 0.419433403835519 2803 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2310 7668677 200 µM -0.20361961310657 0.420771393730979 no 1973 0.419325382594441 2965 2197143
SGTC_1070 indatraline 8.81 µM -0.203831016414798 0.420694463602897 no 1974 0.41924277701834 2795 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2831 7999036 19.48 µM -0.203984733587144 0.420638527487912 no 1975 0.419182714461937 3061 2988270
SGTC_2654 protoveratrine a 100 µM -0.206824544513999 0.419605438582728 no 1976 0.418073443412934 2773 5702278 A heart drug and vasodilator.
SGTC_3147 9097027 49.47 µM -0.207532760269406 0.41934788425676 no 1977 0.417796905276703 2805 25236841
SGTC_2468 5987765 72.9 µM -0.207747401935321 0.419269833096844 no 1978 0.417713101822115 2820 26772094
SGTC_1497 4476-2978 41.3 µM -0.208492026648052 0.418999086350158 no 1979 0.417422403833883 2853 1528379
SGTC_202 3594-0513 34.79 µM -0.208564900748566 0.418972591268205 no 1980 0.417393956549373 2748 708429
SGTC_793 0488-0545 106 µM -0.209086774021561 0.418782862792089 no 1981 0.417190249663402 2764 292548
SGTC_2893 9048488 25.97 µM -0.209270379574417 0.418716116973595 no 1982 0.417118586751287 2798 6467338
SGTC_3161 9100388 49.47 µM -0.20978336091195 0.418529646136241 no 1983 0.416918380084479 2786 25236368
SGTC_617 3770-0098 35 µM -0.209815406072286 0.418517998195026 no 1984 0.416905874194339 2786 5962639
SGTC_2187 6125751 200 µM -0.209815497906421 0.418517964814781 no 1985 0.416905838355426 2819 874498
SGTC_1953 st076800 12.1 µM -0.209970629500343 0.418461577789079 no 1986 0.416845298151834 2801 297591
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.211577266623325 0.417877698200981 no 1987 0.4162184232103 2811 279621
SGTC_2941 9056145 11.23 µM -0.212074519431867 0.417697024583203 no 1988 0.416024449057277 2752 2119517
SGTC_734 2023-0417 80 µM -0.212091371710104 0.417690901720156 no 1989 0.416017875482875 2908 3935732
SGTC_909 3448-9333 149 µM -0.213413996553628 0.41721042069193 no 1990 0.415502032148505 2772 3344074
SGTC_857 0438-0306 1.35 µM -0.213749301702428 0.417088631188655 no 1991 0.415371281258341 2882 4686136
SGTC_1688 st021091 57.6 µM -0.214389097192913 0.416856266815024 no 1992 0.415121821598375 2842 3656366
SGTC_2846 9008642 19.48 µM -0.214565633981404 0.416792156342137 no 1993 0.415052994985623 2927 2992898
SGTC_3092 9117248 49.47 µM -0.215370893664796 0.416499749189729 no 1994 0.414739080510288 2790 17141857
SGTC_2690 usnic acid 100 µM -0.216166095725676 0.416211039513903 no 1995 0.414429140219982 3001 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2766 oltipraz 83.91 µM -0.217020986795068 0.415900709300188 no 1996 0.414095994792665 2936 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2427 5545055 42.75 µM -0.217076608919675 0.415880519974207 no 1997 0.414074321355368 2813 5372858
SGTC_1623 st003709 20.3 µM -0.217131429833474 0.415860621683303 no 1998 0.414052960369907 2777 16192618
SGTC_1889 st059080 5.18 µM -0.217564757517506 0.415703344773176 no 1999 0.413884123061303 2875 176925 Isolated from Daphnopsis sellowiana.
SGTC_1301 naphtanilide LB 4.81 µM -0.218623261382887 0.415319216085964 no 2000 0.413471765571765 2922 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_887 0885-0007 9.62 µM -0.218897375089451 0.415219754011275 no 2001 0.413364995631025 2925 5719458
SGTC_1152 3909-8331 15.9 µM -0.219447400872283 0.415020193718189 no 2002 0.413150774598989 2805 16001939
SGTC_218 alverine citrate 93.75 µM -0.219787113881035 0.414896950031406 no 2003 0.413018477947395 2915 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2630 antimycin a 100 µM -0.222410330494516 0.413945562335983 no 2004 0.411997235316464 2729 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2472 5377652 49.4 µM -0.222662501353866 0.41385413156694 no 2005 0.411899094131272 2844 1610903
SGTC_2715 st079500 56.4 µM -0.223859452283942 0.413420211231936 no 2006 0.411433333707979 2768 28246688
SGTC_1990 st072050 59.8 µM -0.223914666453327 0.41340019746049 no 2007 0.41141185164362 2764 17233948
SGTC_1873 rapamycin 2 nM -0.225653871091458 0.412769894207164 no 2008 0.410735319103894 2807 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3269 9137823 49.47 µM -0.22592334072603 0.41267225608731 no 2009 0.410630521917154 2796 17682936
SGTC_1996 st072960 66.8 µM -0.226442376431899 0.412484206824498 no 2010 0.410428686057397 2860 1719405
SGTC_2858 9025781 8.96 µM -0.2284021763449 0.411774342858761 no 2011 0.409666798843899 2916 4894980 YPL153C RAD53
SGTC_2962 9082311 13.18 µM -0.229578582720157 0.411348372282012 no 2012 0.409209625447943 2790 16459453
SGTC_1396 3511-0007 98.6 µM -0.231561717416261 0.410630526387911 no 2013 0.408439222207837 2940 X1396
SGTC_1686 st019653 115.5 µM -0.23194606983548 0.410491434828517 no 2014 0.408289950764269 2942 97252
SGTC_3320 9137005 35.139 µM -0.233145392430934 0.410057489839316 no 2015 0.407824253943044 2863 4908713
SGTC_3089 9117425 49.47 µM -0.234813039905697 0.409454276291468 no 2016 0.407176923150621 2881 9401657
SGTC_662 k832-1615 104 µM -0.234926745145093 0.409413155158655 no 2017 0.407132795392793 2908 5878478
SGTC_2274 7947094 46.08 µM -0.235817893487643 0.409090908786083 no 2018 0.406786991346388 2808 2971028
SGTC_440 fluspirilene 35.1 µM -0.236875200856096 0.408708657673249 no 2019 0.406376804690454 3057 3396 An atypical antipsychotic.
SGTC_1100 amiodarone 5.07 µM -0.238722776011451 0.408040907592044 no 2020 0.405660277292853 2936 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1064 honokiol 6.76 µM -0.238820572677901 0.408005569372511 no 2021 0.405622358531911 2912 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1730 st033808 45.1 µM -0.238826328849224 0.408003489438981 no 2022 0.405620126715698 2812 1045166
SGTC_1025 k007-0731 70 µM -0.239569500963365 0.407734973604549 no 2023 0.405332005497153 2828 6256118
SGTC_2195 6536160 144.242 µM -0.239725248285217 0.407678705961568 no 2024 0.405271630141897 2819 3834386
SGTC_3133 9127736 49.47 µM -0.240202784142528 0.407506195980857 no 2025 0.405086527712505 2872 27243420
SGTC_1118 chelidonine 707.474 nM -0.240357463134605 0.407450321989696 no 2026 0.40502657559827 2952 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1778 st046819 58.9 µM -0.240696771341466 0.407327761820953 no 2027 0.404895070755994 2844 671715
SGTC_65 0798-0905 34.986 µM -0.242589181538638 0.406644378569002 no 2028 0.404161831397845 3234 3602145
SGTC_1333 1482-0047 286 µM -0.242691083748119 0.406607587899657 no 2029 0.40412235756581 2958 3811116
SGTC_1481 3346-2004 36 µM -0.243236451712889 0.406410702827395 no 2030 0.403911115123304 2861 2770522
SGTC_2495 cafestol 54.53 µM -0.24531806455801 0.40565943087359 no 2031 0.403105082766892 3056 16667697 An anti-infammatory.
SGTC_3088 9117578 49.47 µM -0.246431959281063 0.405257559194946 no 2032 0.402673934486074 2895 678341
SGTC_2810 7959871 45.46 µM -0.24893186196209 0.404356006827902 no 2033 0.401706744311656 2951 2974535
SGTC_24 0417-1663 219 µM -0.249140505928195 0.404280785401325 no 2034 0.401626048938277 2935 4329390
SGTC_2070 5230947 200 µM -0.249198000931835 0.404260057620194 no 2035 0.401603812843508 2946 2835538
SGTC_2746 daunorubicin 9.88 µM -0.249316878418125 0.404217201417849 no 2036 0.401557838188506 2837 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2309 7664088 163.95 µM -0.250221661483403 0.403891058214567 no 2037 0.401207967264189 3001 704922
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.250282574489618 0.403869103566662 no 2038 0.401184415632033 3004 5377381
SGTC_3210 9128157 49.47 µM -0.252359137243688 0.40312083736686 no 2039 0.400381740956232 2976 17590849
SGTC_1336 1486-0901 104 µM -0.252388323220695 0.403110323046655 no 2040 0.400370462396311 2924 5006114
SGTC_1720 st037298 9.481 µM -0.252401901491593 0.403105431464949 no 2041 0.400365215269738 2943 597396
SGTC_764 1951-2361 146 µM -0.253679761725195 0.402645149374001 no 2042 0.399871485255718 2868 5438930
SGTC_3031 9088762 49.47 µM -0.254250265906852 0.402439698704044 no 2043 0.399651109771256 2805 205253
SGTC_3290 9121031 71.43 µM -0.254713767237955 0.402272801867756 no 2044 0.399472091089651 2903 17014854
SGTC_2733 amorolfine 100 µM -0.256222119330303 0.401729800262273 no 2045 0.398889664909843 2888 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1310 1188-0297 994 nM -0.256737511272178 0.401544304345147 no 2046 0.398690706029482 2907 1588352
SGTC_1621 st003705 32.4 µM -0.258878392868997 0.400774012556102 no 2047 0.397864535005634 3027 24207032
SGTC_63 0099-0242 26.702 µM -0.260052408489849 0.400351763850994 no 2048 0.397411673853023 3018 3898502 YLR359W ADE13
SGTC_324 1315-0088 19.6 µM -0.260077770779331 0.400342643284604 no 2049 0.397401892205325 2938 6787421
SGTC_3180 9109287 49.47 µM -0.262538589299848 0.39945796425867 no 2050 0.396453119220611 2987 18891271
SGTC_918 glabranin 770.725 nM -0.262607990567264 0.399433021547041 no 2051 0.396426370297095 2920 124049 Also referred to as licorice root.
SGTC_3209 9113616 49.47 µM -0.263920199325906 0.398961493046051 no 2052 0.395920705254038 3068 16649353
SGTC_3142 9086498 49.47 µM -0.263923001533562 0.398960486259512 no 2053 0.395919625598854 3000 25236367
SGTC_1173 0443-0020 122 µM -0.264078723540254 0.398904538992928 no 2054 0.395859629133643 2874 5331295
SGTC_1079 idarubicin 2.36 µM -0.264321509800411 0.398817315724918 no 2055 0.395766093536483 2945 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_533 1222-0222 6.71 µM -0.265264650550396 0.398478531437818 no 2056 0.395402797047899 3067 3982874
SGTC_252 miconazole 1.30953 nM -0.266661619356458 0.39797686883583 no 2057 0.394864853714461 2979 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_574 1315-0397 40 µM -0.266797527139958 0.397928072257819 no 2058 0.3948125291614 2876 6794277
SGTC_355 1311-2252 105 µM -0.267624552232636 0.397631170109009 no 2059 0.394494165089899 2887 5338538
SGTC_383 2324-0395 7.37 µM -0.269316471790204 0.397023955588732 no 2060 0.393843078825234 3013 3146421
SGTC_3297 9117502 71.43 µM -0.270075491637527 0.396751631277058 no 2061 0.393551088283734 2930 7453720
SGTC_1016 4226-1401 38 µM -0.270889058735063 0.396459792182523 no 2062 0.393238180191006 2839 2901613
SGTC_1624 st003710 6.25 µM -0.271751258125351 0.396150571239246 no 2063 0.392906642772674 3048 24207033
SGTC_2959 9079155 11 µM -0.272252215287906 0.395970936935811 no 2064 0.392714047765011 3042 16189457
SGTC_3069 9117009 49.47 µM -0.274261646674576 0.395250613053778 no 2065 0.391941778170478 2947 41904981
SGTC_1763 st044482 94.5 µM -0.274502445289335 0.395164317571336 no 2066 0.391849262349108 3027 88505
SGTC_2539 epi(13)torulosol 80 µM -0.274755271936412 0.395073717111966 no 2067 0.391752131889061 2997 6708597
SGTC_3168 9103419 49.47 µM -0.274875392776757 0.395030673781884 no 2068 0.391705986457187 2947 16649256
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.27600417319629 0.394626256503958 no 2069 0.391272430471985 2953 6857784
SGTC_614 0462-0418 107 µM -0.277071155737536 0.394244084420603 no 2070 0.390862734738088 2929 5188303
SGTC_1520 flindersine 88 µM -0.277612607189013 0.394050186110321 no 2071 0.390654876644873 3176 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_69 0096-0274 206.684 µM -0.277803957935544 0.393981668078782 no 2072 0.390581426370836 3177 6741392
SGTC_1886 st057356 49.9 µM -0.278338500986727 0.393790278653886 no 2073 0.390376261906309 2881 24207747
SGTC_506 n9-isopropylolomoucine 153 µM -0.278915308718658 0.39358378542934 no 2074 0.390154909956311 3044 6610355
SGTC_312 4092-0653 6.84 µM -0.279054814392769 0.393533847843532 no 2075 0.390101379519268 2999 1148278
SGTC_2764 methyldopa 94.69 µM -0.282574130028936 0.392274651621 no 2076 0.388751656829062 3081 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_867 0518-0118 155 µM -0.283590924886557 0.391911056014478 no 2077 0.388361946299772 2985 6848158
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.284486543415891 0.391590870006485 no 2078 0.388018772505176 2974 77254
SGTC_3101 9120531 49.47 µM -0.284822143330857 0.391470911044199 no 2079 0.387890203323779 3115 24824904
SGTC_3037 9091026 49.47 µM -0.287921446433239 0.390363565644629 no 2080 0.386703434930179 3009 25236398 YIL048W NEO1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.289731813308463 0.389717152978564 no 2081 0.386010708106409 3097 94937 An inhibitor of serotonin biosynthesis.
SGTC_3010 9080089 71.4286 µM -0.289779594150371 0.389700096392727 no 2082 0.385992429943841 3032 17027233
SGTC_3208 9114115 49.47 µM -0.290331327969654 0.389503156380941 no 2083 0.385781387115992 2990 650895
SGTC_536 3852-0578 10.6 µM -0.290889489331476 0.389303950944707 no 2084 0.385567920095586 3087 2869208
SGTC_2402 5553605 200 µM -0.291202388612122 0.389192291231318 no 2085 0.385448267926181 3117 6758546
SGTC_2987 9018338 71.43 µM -0.291563497578316 0.38906343901782 no 2086 0.385310194003925 2970 5055682
SGTC_1056 3448-1962 115 µM -0.291717331317881 0.389008551208677 no 2087 0.385251378422724 3002 715507
SGTC_2584 androsterone 48.74 µM -0.292068685107289 0.388883196643219 no 2088 0.385117054480634 3053 2754130 A steroid.
SGTC_1423 4048-0112 5.59 µM -0.292151334621073 0.388853710968384 no 2089 0.385085459246869 3001 X1423
SGTC_1463 k081-0032 34.1 µM -0.292656910182358 0.388673358010548 no 2090 0.384892204572136 2998 977755
SGTC_16 erodoxin 22.806 µM -0.293714235458823 0.388296258082593 no 2091 0.384488137773184 3033 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2076 5212012 200 µM -0.294173533848698 0.388132479975403 no 2092 0.384312651637502 2889 604802
SGTC_2253 7938677 135.83 µM -0.294738945711297 0.387930890902905 no 2093 0.384096654826868 3127 2301972
SGTC_27 0485-0001 32.618 µM -0.297247706316722 0.387036795103708 no 2094 0.383138701238441 2910 2054479
SGTC_2907 7721985 69.9 µM -0.29975259039883 0.386144678454606 no 2095 0.382182940319284 3003 3267881
SGTC_1461 k072-0203 53.8 µM -0.300293973415354 0.385951943330083 no 2096 0.381976464877783 2956 5418714
SGTC_358 0075-0058 9.45 µM -0.301512364175519 0.385518293002426 no 2097 0.381511911591112 2929 1069125
SGTC_1669 st015249 58.4 µM -0.30237150243525 0.385212594006836 no 2098 0.381184438189077 3032 722793
SGTC_2770 toltrazuril 17.5 µM -0.302411167241538 0.385198482176946 no 2099 0.381169321407187 2963 68591 Kills coccidiodes.
SGTC_1724 st037281 8.293 µM -0.3035343793073 0.384798932214224 no 2100 0.380741325794883 2916 574124 YDL195W SEC31
SGTC_1857 st056007 79.3 µM -0.304041525383752 0.384618569830065 no 2101 0.380548127522736 3010 619834
SGTC_541 4513-1321 94 µM -0.304145328089437 0.384581656318012 no 2102 0.380508587353533 2952 747515
SGTC_2898 9056270 58.44 µM -0.304232725368105 0.384550577587927 no 2103 0.380475297251047 2937 19154699
SGTC_2007 4011539 71.82 µM -0.304929103303726 0.384302970065687 no 2104 0.380210074722047 2925 45595301
SGTC_450 aminopyrene 156 nM -0.306565628149443 0.383721265318755 no 2105 0.379587009679273 3070 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_637 1181-0519 7.26 µM -0.306569913845273 0.383719742306279 no 2106 0.379585378419646 2951 6252091 YGR060W ERG25
SGTC_78 0336-0123 156.75 µM -0.307291635874112 0.383463288788822 no 2107 0.379310700760937 2868 6765896
SGTC_3353 9151644 39.2805 µM -0.307371217931542 0.383435013574925 no 2108 0.379280416630667 3071 4909158
SGTC_862 0452-0056 10.2 µM -0.310031925857771 0.382490032012058 no 2109 0.37826833918553 3026 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_21 0849-0113 22.993 µM -0.311014577258934 0.382141208389687 no 2110 0.377894769890843 2958 1560156
SGTC_629 3448-6466 76.7 µM -0.311228839163417 0.382065161947583 no 2111 0.377813330243229 2988 573744
SGTC_1254 0550-0035 264 µM -0.311462338775084 0.381982292784833 no 2112 0.377724584644009 3093 15121435
SGTC_3243 9134147 49.47 µM -0.311504097562135 0.381967473134229 no 2113 0.37770871416898 3015 24282180
SGTC_724 3910-0327 137 µM -0.311685457680426 0.381903112793121 no 2114 0.37763979044309 3022 2885483
SGTC_2833 9001315 45.46 µM -0.312890816419844 0.381475442999082 no 2115 0.377181807481081 2934 2989378
SGTC_1742 st038235 28.8875 µM -0.314397701420433 0.380940993086322 no 2116 0.376609500855495 3075 564103 YBR002C RER2
SGTC_1422 4031-0024 15.5 µM -0.314886662102696 0.380767621167757 no 2117 0.376423854474187 3017 782427
SGTC_1888 azatryptophan 97.5 µM -0.317041732437659 0.380003778604048 no 2118 0.375605968242665 3072 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_612 0302-0167 22.4 µM -0.3174582098762 0.379856216302043 no 2119 0.375447972201126 3030 235821
SGTC_2747 doxorubicin 7.63 µM -0.317628793995162 0.379795781616999 no 2120 0.375383264962874 2990 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2625 euphol 100 µM -0.318383181965404 0.379528551631362 no 2121 0.375097146959095 3117 6708538 A triterpene alcohol.
SGTC_1944 st076371 56.9 µM -0.319159686460265 0.379253547308968 no 2122 0.374802712549107 2943 24208455
SGTC_562 3772-2733 112 µM -0.319981624852236 0.378962518821874 no 2123 0.374491130039081 3093 2876874 YIL048W NEO1
SGTC_883 0850-0245 24.6 µM -0.320200724040065 0.378884952677541 no 2124 0.374408087182012 3165 6823229 YPR165W RHO1
SGTC_2403 6032726 181.2 µM -0.320891815460378 0.378640322412445 no 2125 0.374146188266699 3041 2881040
SGTC_1266 0828-0227 32.9 µM -0.32486075820092 0.377236353302882 no 2126 0.372643228897018 3087 3913820
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.325088247497732 0.377155930456933 no 2127 0.37255714172238 3073 7104
SGTC_352 k048-0007 5.11 µM -0.325332616916376 0.37706954602468 no 2128 0.37246467381444 3067 6811911
SGTC_3229 9132204 49.47 µM -0.32583312288882 0.376892636694271 no 2129 0.372275308337822 2976 17682924
SGTC_1507 4075-3230 155 µM -0.327694936932782 0.376234785220863 no 2130 0.371571165974716 2996 659771
SGTC_2989 9073649 71.4286 µM -0.329503702853732 0.375596021862686 no 2131 0.370887497804414 3035 21367202
SGTC_1510 1123-0200 71.5 µM -0.330279321674921 0.375322217386323 no 2132 0.370594458006393 3181 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1482 3346-2049 8.48 µM -0.333617887115332 0.374144374807909 no 2133 0.369333959451189 3073 3826804
SGTC_84 0443-0269 128.823 µM -0.334302956087993 0.373902827950609 no 2134 0.369075480001876 3106 6150058
SGTC_1914 st062367 72.6 µM -0.334660885018249 0.373776646316362 no 2135 0.368940455422365 2984 978205
SGTC_2778 tioconazole 65.09 nM -0.334703586178604 0.373761593666071 no 2136 0.368924347979389 2959 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1741 st038134 10.228 µM -0.338441310272573 0.372444751372733 no 2137 0.367515323876219 3233 1272587
SGTC_2487 5918373 44.05 µM -0.340607554727221 0.371682239949506 no 2138 0.366699520671804 3118 2876279
SGTC_1241 0364-0022 50.8 µM -0.340813527370168 0.371609764357852 no 2139 0.366621983071216 3036 4563895
SGTC_2651 TUB2.036 5 µM -0.341181092571611 0.371480440502516 no 2140 0.366483628105096 3164 15992207 YFL037W TUB2
SGTC_2819 7996655 46.38 µM -0.342196181490345 0.371123367791482 no 2141 0.366101629346505 3048 6456960
SGTC_2940 9060638 45.86 µM -0.34261507365122 0.370976048521379 no 2142 0.365944030293646 3105 4027022
SGTC_1426 4048-4480 71.7 µM -0.343111512327759 0.370801481570519 no 2143 0.365757285339705 3118 14224343
SGTC_420 mitomycin C 81.9 mM -0.343707234297768 0.370592037892612 no 2144 0.365533235053228 3006 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_828 2074-0507 139 µM -0.343896742654306 0.370525418661692 no 2145 0.365461970811491 3158 X828
SGTC_306 1672-3436 11.6 µM -0.346478468714879 0.369618233486795 no 2146 0.364491581395656 3117 6797378
SGTC_2647 atorvastatin 60.16 µM -0.350698031846722 0.368137096889772 no 2147 0.362907451126894 3078 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_575 k072-0246 11.9 µM -0.352587896468069 0.367474356570764 no 2148 0.362198706392327 3043 6796779
SGTC_646 4092-0839 27.3 µM -0.352692340509253 0.367437741477491 no 2149 0.36215955110851 3169 877796
SGTC_1897 st060201 15 µM -0.353964993673559 0.366991682584109 no 2150 0.361682559003076 3044 611878
SGTC_2975 9084847 53.72 µM -0.354286862239058 0.366878897595871 no 2151 0.36156195624458 3107 27211724
SGTC_1351 1496-0003 46.5 µM -0.3568426068973 0.365983755422438 no 2152 0.360604818800996 3161 3891978
SGTC_404 fumagillin 50 µM -0.357226860084589 0.365849234778541 no 2153 0.360460989636421 3104 12015870 A methionine aminopeptidase binder.
SGTC_439 amiodarone 34.4 µM -0.359130572656387 0.365183020245174 no 2154 0.359748705726017 3044 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1168 k815-0004 80.5 µM -0.360075048496482 0.364852646606867 no 2155 0.359395505732354 3003 642433
SGTC_584 0986-0246 15.4 µM -0.360620833140338 0.364661779175106 no 2156 0.359191456640847 3129 53315 YDR232W HEM1
SGTC_1960 st011366 51.8 µM -0.361224174262365 0.364450822588828 no 2157 0.358965936003774 3013 3972846
SGTC_1680 diphenhydramine 100 µM -0.361254484460835 0.364440225792542 no 2158 0.358954607763138 3072 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2061 5245884 80.95 µM -0.361773624371185 0.364258744559334 no 2159 0.358760601842979 3023 573863
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.364122230063061 0.363438098385497 no 2160 0.3578833687191 3170 5024745
SGTC_2301 7769476 200 µM -0.364684645941256 0.363241672706527 no 2161 0.357673410596304 3104 977820
SGTC_187 1488-2104 32.728 µM -0.36476621705738 0.363213186698574 no 2162 0.357642962472501 3114 2852859
SGTC_82 0054-0107 293.755 µM -0.366162835640674 0.362725581449723 no 2163 0.357121786088822 3105 3104697
SGTC_2656 pseudo-anisatin 100 µM -0.366612827320992 0.362568521989791 no 2164 0.356953919335054 3060 6708809 A neurotoxin.
SGTC_1227 3909-8010 46.6 µM -0.36790707799922 0.362116921922664 no 2165 0.35647126117988 3053 15982272
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.368501551524207 0.361909557837396 no 2166 0.356249644232951 3238 165506
SGTC_1097 itavastatin 7.23 µM -0.369257708805414 0.361645853845121 no 2167 0.355967822489992 3087 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2197 6588183 93.1375 µM -0.372414620795761 0.360545616204301 no 2168 0.354792084873152 3048 884136
SGTC_2445 5742597 35.57 µM -0.372540310721824 0.360501834941209 no 2169 0.354745302349607 3042 1774255
SGTC_2278 7948257 134.34 µM -0.373074554984831 0.360315763362402 no 2170 0.354546477969849 3183 1247028
SGTC_954 1189-0853 2.85 µM -0.374058853282484 0.359973029409849 no 2171 0.354180265241346 3075 2828194
SGTC_3313 9133968 57.047 µM -0.375261248034136 0.359554506717114 no 2172 0.353733091674589 3089 1494643
SGTC_389 tpck 16.7 µM -0.376172366667468 0.359237481870403 no 2173 0.353394378725983 3135 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_878 0828-0289 13.7 µM -0.376910251192672 0.358980805041265 no 2174 0.353120151484511 3081 745350 YLR208W SEC13
SGTC_600 1495-0418 41.6 µM -0.377517475372346 0.35876962680656 no 2175 0.352894540016622 3069 5377768
SGTC_1619 st003326 88.7 µM -0.377778753112387 0.358678773855405 no 2176 0.352797479332258 3216 2849032
SGTC_2802 7925815 54.55 µM -0.37983044264126 0.357965627241122 no 2177 0.352035641474456 3046 1262923
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.380412882818975 0.357763267069368 no 2178 0.35181947654115 3187 688662
SGTC_1377 2944-0135 198 µM -0.380961096014011 0.357572835067563 no 2179 0.351616058247783 3124 1894137
SGTC_2512 diallyl trisulfide 49.23 µM -0.383687854942987 0.356626172434509 no 2180 0.350604907639651 3143 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2551 apiole 73.87 µM -0.385219060613622 0.35609496257738 no 2181 0.35003756133888 3080 10659 A possible DNA adduct former.
SGTC_2096 5468907 200 µM -0.385650438076256 0.355945358348766 no 2182 0.349877786594222 3167 759785
SGTC_1291 0993-0025 5.79 µM -0.387233604843707 0.355396497067098 no 2183 0.349291636984723 3193 4353356
SGTC_2482 5981709 142.65 µM -0.388393675123406 0.354994507524721 no 2184 0.348862362054056 3114 877755
SGTC_71 0417-1750 47.813 µM -0.38868260523697 0.35489441204806 no 2185 0.348755475785557 3261 6811472
SGTC_1275 0867-0008 21.1 µM -0.390767775515362 0.354172333608824 no 2186 0.347984448124071 3046 3422836
SGTC_1659 st012954 42.1 µM -0.39293134506846 0.353423660010836 no 2187 0.34718509486839 3201 24207262
SGTC_33 0986-0033 35.816 µM -0.393052244998981 0.353381840940776 no 2188 0.347140447142517 3159 2848082
SGTC_1192 1488-0095 21.4 µM -0.39317461881485 0.35333951385893 no 2189 0.347095257278889 3173 915875
SGTC_3008 9078912 71.4286 µM -0.394841550657448 0.352763130501418 no 2190 0.346479914067636 3106 16648731
SGTC_717 1532-0246 73.2 µM -0.396545472054259 0.352174306175208 no 2191 0.345851334722698 3158 9561992
SGTC_1892 st058411 7.36 µM -0.396668214408446 0.352131903745488 no 2192 0.345806071246186 3216 3934738
SGTC_1711 st032263 62.8 µM -0.396714654037628 0.352115861244984 no 2193 0.345788946362507 3133 3958979
SGTC_2465 5809242 33.21 µM -0.396930955415135 0.352041143725466 no 2194 0.345709188127436 3114 2731748
SGTC_1445 4239-0156 97.7 µM -0.397715348568008 0.351770236795404 no 2195 0.34542001112471 3278 4008346
SGTC_838 0109-0203 71.4 µM -0.398939649150064 0.351347548856165 no 2196 0.344968836696922 3116 759422
SGTC_1389 3405-0187 19 µM -0.400862788149334 0.350683959240356 no 2197 0.344260574138281 3144 799890
SGTC_2142 5622915 118.518 µM -0.402770596259964 0.350026109457604 no 2198 0.343558496995099 3145 5322196
SGTC_496 calpeptin 138 µM -0.402984642080842 0.349952330276901 no 2199 0.343479761317805 3165 73364 A calpain inhibitor.
SGTC_2673 kobusone 100 µM -0.403045956991693 0.349931196762162 no 2200 0.343457208187825 3138 6710676 An epoxy ketone and protein crosslinker.
SGTC_1220 1838-0075 193 µM -0.405312938620926 0.349150159161503 no 2201 0.342623748512118 3134 5529645
SGTC_1494 4358-1428 177 µM -0.406148130980414 0.348862573165381 no 2202 0.342316881374309 3250 1564571
SGTC_1938 st074717 56.4 µM -0.406342929417846 0.34879550971539 no 2203 0.342245323316335 3134 17250979
SGTC_647 0140-0236 81 µM -0.406730951690605 0.348661938983191 no 2204 0.342102802501005 3157 990837
SGTC_3264 9137442 49.47 µM -0.409297866446138 0.347778791029519 no 2205 0.341160540535005 3338 17015726
SGTC_3177 9107506 49.47 µM -0.40946065264978 0.3477228121562 no 2206 0.341100818354595 3203 8897194
SGTC_980 1473-0395 201 µM -0.410595308048412 0.347332719452116 no 2207 0.340684652354186 3090 768876
SGTC_1606 st000094 49.2 µM -0.411376043137349 0.347064397841842 no 2208 0.340398408887583 3250 1242210
SGTC_109 0132-0036 33.701 µM -0.412231155350796 0.346770602397583 no 2209 0.340085001769085 3054 67274 A color developer.
SGTC_1045 1348-1485 165 µM -0.413934392050051 0.346185686932811 no 2210 0.339461077911285 3132 6810614
SGTC_1508 1080-0625 72.9 µM -0.413939369849581 0.346183978023154 no 2211 0.339459255104454 3149 767111
SGTC_1747 st037496 66.6 µM -0.414375998928813 0.346034092723782 no 2212 0.339299381710826 3121 723305
SGTC_2044 5102272 200 µM -0.414879307447543 0.345861347743858 no 2213 0.339115129274844 3227 592666
SGTC_400 oxethazaine 37.5 µM -0.414914053531429 0.345849423415668 no 2214 0.339102410761054 3205 4621 A local anesthetic.
SGTC_1729 st035615 45.989 µM -0.415423509402208 0.345674603460931 no 2215 0.338915949754813 3221 17385451
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.416220934208056 0.345401032938052 no 2216 0.338624171262133 3263 756377
SGTC_2240 6690706 185.951 µM -0.416673951473083 0.345245653398882 no 2217 0.338458454933852 3022 805876
SGTC_3051 9093778 49.47 µM -0.416806283992213 0.345200269838199 no 2218 0.338410052836686 3191 17217378
SGTC_1793 st048256 72.231 µM -0.417445520413393 0.344981074470816 no 2219 0.33817628258194 3153 672022
SGTC_453 enantio-paf c16 10 µM -0.418047639774823 0.34477465417807 no 2220 0.3379561431665 3233 13871343 A lipid and platelet activating factor
SGTC_278 4092-0821 23.9 µM -0.4185887826277 0.344589177443688 no 2221 0.337758344497294 3217 877900
SGTC_419 nsc-638432 893 µM -0.42001941512371 0.344099008122811 no 2222 0.337235635257188 3192 368090
SGTC_1163 k060-0048 49.9 µM -0.420056281001022 0.344086380438045 no 2223 0.337222169742375 3140 6809982
SGTC_696 1560-0013 611 µM -0.42121346147503 0.343690099359147 no 2224 0.336799607703792 3324 1650269
SGTC_1239 0337-0584 35.4 µM -0.42358911609934 0.342877085405323 no 2225 0.335932747121605 3310 914301 YML130C ERO1
SGTC_1139 k015-0024 46.9 µM -0.424346695764353 0.342617973646972 no 2226 0.335656494496691 3261 2766652
SGTC_1588 farnesol 29.9 µM -0.425124071299694 0.342352168151655 no 2227 0.335373115582577 3146 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2897 9048598 12.99 µM -0.425833654354753 0.34210961086933 no 2228 0.335114530993886 3153 6467404
SGTC_1912 st060209 90.8 µM -0.426099038143517 0.342018911270029 no 2229 0.335017840524591 3194 688787
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.428594890925175 0.34116635609037 no 2230 0.334109032128449 3315 551469
SGTC_1400 3771-8998 51.5 µM -0.428653674424344 0.341146286058775 no 2231 0.334087639139097 3149 670767
SGTC_2763 lisinopril 49.32 µM -0.428710679297565 0.34112682371999 no 2232 0.334066893957208 3242 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_645 0845-0943 5.41 µM -0.428861719820749 0.341075258210528 no 2233 0.334011929825055 3197 1885106
SGTC_475 α-linolenic acid 10 µM -0.431126892623937 0.340302280615467 no 2234 0.33318805379581 3382 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2174 5790901 200 µM -0.431215730997892 0.340271978659471 no 2235 0.333155758363288 3225 786020
SGTC_800 3448-7362 155 µM -0.431703146148593 0.340105744171816 no 2236 0.33297859025244 3245 15991913
SGTC_2688 kanamycin b 96.69 µM -0.432774790087594 0.339740365909052 no 2237 0.332589194842595 3341 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1641 st009299 47.1 µM -0.434404598127494 0.339184969574601 no 2238 0.331997329654913 3253 4046054
SGTC_330 1488-0319 80.1 µM -0.435641475110688 0.338763706974812 no 2239 0.331548436986343 3224 6846614
SGTC_1414 3917-0015 5.4 µM -0.437703592551664 0.338061827716576 no 2240 0.330800582448947 3262 6618702
SGTC_2705 st078069 42.8 µM -0.437940300124519 0.337981295926702 no 2241 0.33071478039491 3233 1530061
SGTC_2430 5571206 200 µM -0.43908048951747 0.337593488766487 no 2242 0.330301607803882 3329 1731771
SGTC_2448 5185112 27.17 µM -0.440459076624786 0.33712482679195 no 2243 0.329802322796257 3283 5718189
SGTC_3339 9145883 14.936 µM -0.441163261905597 0.336885530688402 no 2244 0.329547403831045 3266 2030670
SGTC_3268 9137683 49.47 µM -0.443363815485016 0.336138164811283 no 2245 0.328751302068262 3158 1953228
SGTC_2689 tacrolimus 100 µM -0.444608530844843 0.335715713123569 no 2246 0.328301340709302 3240 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1221 2958-7315 257 µM -0.444895358505061 0.33561839430272 no 2247 0.328197688529792 3265 4562705
SGTC_2744 captopril 92.04 µM -0.445675057070027 0.335353903220478 no 2248 0.327915992275452 3235 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2477 5967686 25.23 µM -0.446501892213291 0.335073511496553 no 2249 0.327617373036831 3130 776118
SGTC_2743 auranofin 4.32 µM -0.446838567122059 0.334959366494321 no 2250 0.32749581131671 3203 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2139 5578692 56.4705 µM -0.446848939010299 0.334955850290096 no 2251 0.327492066675192 3255 650991 YMR113W FOL3
SGTC_2357 9067248 200 µM -0.447197520271665 0.334837685150356 no 2252 0.327366225832345 3272 9150235
SGTC_1717 st033143 58.0435 µM -0.448705790262058 0.334326587095823 no 2253 0.326821953561479 3353 674616
SGTC_957 1187-1561 14.1 µM -0.450053121615402 0.333870284850933 no 2254 0.326336068742194 3289 1538454
SGTC_1769 st044406 64.4 µM -0.450686492617355 0.333655865172576 no 2255 0.32610775943425 3171 670903
SGTC_1570 verbenone 133 µM -0.45101785926728 0.333543706856306 no 2256 0.325988338670463 3348 29025 A natural terpanoid with antifungal properties.
SGTC_1898 st060199 18.6 µM -0.451501849095097 0.333379916609565 no 2257 0.325813946324861 3190 688866
SGTC_961 1252-1571 372 µM -0.452017670775413 0.333205388897518 no 2258 0.325628126198619 3351 6813498
SGTC_3325 9138760 55.175 µM -0.452273025914803 0.333119003121181 no 2259 0.325536152832507 3194 43844959
SGTC_319 1348-1596 45.5 µM -0.452736611965712 0.332962196164531 no 2260 0.325369206370126 3352 5380505
SGTC_458 nppb 133 µM -0.455404061664363 0.332060505400701 no 2261 0.324409286874763 3371 4549 A chloride channel blocker.
SGTC_2491 paeonol 100 µM -0.45580702717743 0.331924373391285 no 2262 0.324264375225955 3235 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2191 5911152 200 µM -0.456462182005004 0.331703092772589 no 2263 0.324028829832229 3251 2875902
SGTC_1806 st050005 60.3 µM -0.456972164140542 0.331530885323072 no 2264 0.323845526585584 3211 5194765
SGTC_2289 7946404 165.07 µM -0.457866269625089 0.331229055549214 no 2265 0.323524260717326 3174 1246120 YPR165W RHO1
SGTC_1759 st043059 70 µM -0.461790689324359 0.329905558892666 no 2266 0.322115714193591 3173 669426
SGTC_3163 9099914 49.47 µM -0.462872300842996 0.329541162328725 no 2267 0.321727951484644 3288 16268368
SGTC_1693 xanthone 101.9 µM -0.465755416605447 0.328570627423269 no 2268 0.320695290359865 3253 7020 An insecticide.
SGTC_2683 piperine 63.03 µM -0.465945272430191 0.328506757283072 no 2269 0.320627337232716 3236 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3294 9122953 26.2835 µM -0.468732835158654 0.327569560115127 no 2270 0.319630306856481 3242 16459826
SGTC_2079 5212404 121 µM -0.469030867724571 0.327469423706984 no 2271 0.319523786177968 3361 758462
SGTC_2828 7998861 71.43 µM -0.470508301474683 0.326973201912098 no 2272 0.318995952318705 3307 2988188
SGTC_1561 5-methoxyflavone 52.9 µM -0.471368944624611 0.32668428083884 no 2273 0.318688644531992 3289 94525
SGTC_1526 st051518 75 µM -0.4718522212768 0.326522088630685 no 2274 0.318516136731311 3221 673993
SGTC_925 2064-1272 59.6 µM -0.471930390679736 0.326495857320785 no 2275 0.318488237501909 3233 6815817
SGTC_1634 st006576 41 µM -0.472337870560468 0.326359133174495 no 2276 0.318342821632567 3387 3915356
SGTC_143 4032-1194 15.74 µM -0.474290489289646 0.325704283412073 no 2277 0.317646386346595 3224 1806963
SGTC_704 1310-0270 142 µM -0.474996132936491 0.325467763799768 no 2278 0.317394864795808 3275 5718033
SGTC_3298 9116858 71.43 µM -0.47508691590639 0.325437340009469 no 2279 0.317362511983421 3352 2506942
SGTC_763 3453-1109 128 µM -0.475098888697614 0.325433327695167 no 2280 0.317358245279937 3380 1560353
SGTC_977 1348-1378 135 µM -0.477976737254342 0.324469492676997 no 2281 0.316333381155225 3219 X977
SGTC_236 1509-0011 5.31 µM -0.47827988824302 0.324368031099096 no 2282 0.316225504432817 3405 3107280
SGTC_1902 st060212 70.5 µM -0.478417513035138 0.324321973772029 no 2283 0.316176535610761 3365 688944
SGTC_1381 2324-0066 62.1 µM -0.47966256284394 0.323905429297036 no 2284 0.315733676115527 3300 10885928
SGTC_2244 6635614 200 µM -0.482960448031597 0.322803153495613 no 2285 0.314561909958193 3102 836499
SGTC_3003 9075612 71.4286 µM -0.483225046764279 0.322714782025195 no 2286 0.314467976501377 3297 6501993
SGTC_2869 9037858 32.47 µM -0.483674910819645 0.322564558075228 no 2287 0.314308300789572 3270 27187042
SGTC_2138 5575593 77.673 µM -0.485247198486489 0.322039748722554 no 2288 0.313750502682486 3274 762213
SGTC_1519 esterone 74 µM -0.48628937472768 0.321692079118981 no 2289 0.313381005777729 3209 698 A steroid.
SGTC_1696 st025591 34.7925 µM -0.486927937062245 0.321479132058475 no 2290 0.313154700073432 3272 2787147
SGTC_1981 st071826 47 µM -0.487786562016093 0.321192891225402 no 2291 0.312850515362751 3307 11838600
SGTC_2203 7227154 166.4 µM -0.488563029931233 0.320934130612724 no 2292 0.31257554606309 3341 896304
SGTC_1563 conessine 56.1 µM -0.488791737298644 0.320857929664847 no 2293 0.312494574178765 3355 441082 An anti-amoebic, histamine inhibitor.
SGTC_3152 9099253 49.47 µM -0.489876474990624 0.320496618497823 no 2294 0.312110655416351 3308 25236131
SGTC_2857 9024691 58.44 µM -0.490704770224882 0.320220839252412 no 2295 0.311817636065201 3328 16478292
SGTC_981 1488-1094 54.9 µM -0.490931654150466 0.320145316016916 no 2296 0.311737393930109 3297 3449522
SGTC_2653 dihydrofissinolide 100 µM -0.491387776643419 0.319993508301701 no 2297 0.31157610394001 3362 6857746
SGTC_1748 st037455 53.6035 µM -0.492328785385933 0.319680414894126 no 2298 0.311243467013383 3396 580690
SGTC_2967 9089538 49.85 µM -0.495720022793645 0.318553145793455 no 2299 0.310045979143816 3428 728216
SGTC_391 gliotoxin 8.33 µM -0.497053571519566 0.318110324534738 no 2300 0.309575637013096 3424 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3085 9117376 49.47 µM -0.505018415358295 0.315470929162869 no 2301 0.306772950878913 3380 16480349
SGTC_1603 st002045 67.8 µM -0.50743035911607 0.314673503126768 no 2302 0.305926444310275 3396 5887985
SGTC_2990 9074105 71.4286 µM -0.508426311272771 0.314344477580678 no 2303 0.305577202321233 3361 6502001
SGTC_2929 9013348 24.6 µM -0.508612873407086 0.314282860779783 no 2304 0.305511801833162 3329 2995952
SGTC_2719 novobiocin 32.65 µM -0.508676863603906 0.31426172761205 no 2305 0.305489371110592 3404 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2226 7298446 200 µM -0.509101063454072 0.314121648323906 no 2306 0.305340693219435 3378 3283010
SGTC_983 1491-0821 12.2 µM -0.510802039800332 0.313560220942149 no 2307 0.304744840350968 3376 46495113
SGTC_1297 1068-0111 14.1 µM -0.512387902087423 0.313037177026022 no 2308 0.304189778111649 3290 767057
SGTC_3247 9135149 49.47 µM -0.513063904896943 0.312814334232645 no 2309 0.303953309670255 3328 8934436 YOR116C RPO31
SGTC_2122 5258151 111.688 µM -0.514005614305619 0.312504015862781 no 2310 0.303624032714135 3304 2173356
SGTC_2145 5634607 200 µM -0.514229470606795 0.312430268783004 no 2311 0.30354578282795 3284 308662
SGTC_2334 9017922 200 µM -0.516553273041431 0.311665160934703 no 2312 0.302734020764487 3366 3163164
SGTC_2336 9001819 198.65 µM -0.51668195579861 0.311622816072194 no 2313 0.30268909709952 3495 2989602
SGTC_2132 5317594 122.667 µM -0.517088307071829 0.311489116852676 no 2314 0.302547257855392 3279 794577
SGTC_1009 4106-0057 9.87 µM -0.51871625286484 0.310953733407965 no 2315 0.301979313044816 3437 2928005
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.519383678417158 0.310734352305542 no 2316 0.301746605411792 3272 688667
SGTC_3309 9129340 25.759 µM -0.521992570616335 0.309877461987577 no 2317 0.300837751685521 3342 17158987
SGTC_1187 1391-0724 117 µM -0.522810749648038 0.309608943510545 no 2318 0.300552979111141 3382 6997986
SGTC_816 0325-0417 81.3 µM -0.523085714809494 0.309518725393483 no 2319 0.300457303019442 3386 68101
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.523209247380699 0.309478197173255 no 2320 0.300414323458378 3355 6708561
SGTC_2137 5261020 140 µM -0.523516662372706 0.309377351381409 no 2321 0.300307379422021 3327 763655
SGTC_1511 0906-3109 28.5 µM -0.523957713773978 0.309232691976514 no 2322 0.300153975790122 3405 2882180
SGTC_2602 kawain 100 µM -0.524279992060277 0.309127007379021 no 2323 0.300041905463206 3406 5369129
SGTC_599 1935-0052 86.5 µM -0.527986479780685 0.30791267739422 no 2324 0.298754359974479 3296 9557311
SGTC_1658 st012944 20 µM -0.528549062900617 0.307728545607497 no 2325 0.29855915172591 3388 24207260
SGTC_2055 5235184 200 µM -0.529160382925016 0.307528517266098 no 2326 0.298347098270685 3425 2836034
SGTC_996 3970-0799 1.8 µM -0.529791871603104 0.307321949673824 no 2327 0.298128120771039 3405 6615648 YGL040C HEM2
SGTC_2780 5215298 71.43 µM -0.53004117977576 0.307240414773463 no 2328 0.298041689851637 3442 2834131
SGTC_3109 9122853 49.47 µM -0.530414752181057 0.307118257757744 no 2329 0.297912200007208 3383 1234709
SGTC_900 1112-0045 141 µM -0.530701741458057 0.307024427692457 no 2330 0.297812739536055 3356 56211 YIL048W NEO1
SGTC_1031 k035-0009 16 µM -0.530780266819716 0.306998756322275 no 2331 0.297785528024276 3446 5180959
SGTC_1458 k015-0034 6.33 µM -0.531868204903205 0.306643186965972 no 2332 0.297408639961807 3366 3598957
SGTC_524 r073-0010 27.8 µM -0.53232267992962 0.306494705343479 no 2333 0.29725126336396 3330 2772106
SGTC_196 k015-0023 18.111 µM -0.532431787303613 0.306459063579463 no 2334 0.297213487091725 3362 5211998
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.532830731620901 0.306328757276866 no 2335 0.297075379188888 3336 5106787 A p450 inhibitor.
SGTC_2619 obliquin 87.91 µM -0.5341761721618 0.305889479647649 no 2336 0.296609826524993 3397 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2201 6605497 169.863 µM -0.534590488354171 0.305754264266332 no 2337 0.296466531141037 3377 670741
SGTC_747 3448-8087 38.7 µM -0.534884573395072 0.305658303342629 no 2338 0.29636483815525 3356 5168703
SGTC_166 k072-0058 166.424 µM -0.53534640106904 0.305507634378036 no 2339 0.296205172976541 3451 5846229
SGTC_1113 artemisinin 1.17947 µM -0.53654334696342 0.305117290109102 no 2340 0.295791543133986 3433 2240 An anti-malaria and mitochondrial poison.
SGTC_528 3492-0019 172 µM -0.537086592914592 0.304940201510127 no 2341 0.295603900650602 3432 2869262
SGTC_2528 xanthyletin 44.79 µM -0.537336951336747 0.304858604452975 no 2342 0.295517442818873 3337 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2377 9073351 62.6 µM -0.539452416890539 0.304169517635522 no 2343 0.294787360638476 3330 7337946 YHR072W ERG7
SGTC_3182 9108849 49.47 µM -0.541474920321651 0.30351136174505 no 2344 0.294090139799305 3455 17133045
SGTC_1397 3532-0190 20.1 µM -0.541891604949653 0.303375844769669 no 2345 0.293946590183371 3325 5322280
SGTC_247 mechlorethamine 29.705 µM -0.541920307472041 0.303366510937883 no 2346 0.293936703235988 3376 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3122 9126309 49.47 µM -0.543143073482276 0.302968996413762 no 2347 0.293515648896315 3456 17591206
SGTC_287 k060-0039 29.6 µM -0.543261422431887 0.302930534195332 no 2348 0.293474910763177 3453 5861974
SGTC_489 paxilline 115 µM -0.543709195868546 0.302785032113195 no 2349 0.293320801677065 3418 105008 A toxic potassium channel blocker.
SGTC_2582 agaric acid 100 µM -0.546682022274571 0.301819819532967 no 2350 0.292298603653256 3420 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2134 5324836 1.464 µM -0.546698037670441 0.301814623426388 no 2351 0.292293101293901 3318 699272
SGTC_3015 9080845 49.47 µM -0.547601464720952 0.301521576648475 no 2352 0.291982791732736 3461 5296973
SGTC_12 0849-0099 9.267 µM -0.547847828806573 0.301441685166827 no 2353 0.291898197103083 3398 6071388
SGTC_2298 7976326 193.81 µM -0.547875824815314 0.301432607163078 no 2354 0.291888584768452 3366 2235818
SGTC_3046 9092212 49.47 µM -0.550294486011194 0.300648795543659 no 2355 0.291058702800151 3421 25236637
SGTC_299 1273-0059 1.44 µM -0.550378629431106 0.300621543888534 no 2356 0.291029851674024 3425 2848077
SGTC_2129 girgensonine 121.053 µM -0.550931532118075 0.300442502214181 no 2357 0.290840305442227 3383 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_871 0574-0004 149 µM -0.552680216521103 0.299876558291921 no 2358 0.290241201247242 3328 9551173
SGTC_702 1488-0190 94 µM -0.55310714277483 0.299738461277192 no 2359 0.290095022957189 3448 949357
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.5532941721957 0.299677972304058 no 2360 0.290030995505925 3355 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_273 hydroxyurea 18.1 mM -0.553769691886831 0.299524204842998 no 2361 0.289868236445083 3446 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3263 9137018 49.47 µM -0.55405818740612 0.29943093229407 no 2362 0.289769512186928 3393 43844957
SGTC_181 1447-1644 8.07 µM -0.554074736762653 0.299425582174802 no 2363 0.289763849413 3427 534600
SGTC_552 k242-0005 476 µM -0.554764493038858 0.29920263452326 no 2364 0.289527878343493 3475 4088318
SGTC_3300 9124615 50.48 µM -0.555499199507597 0.298965240658213 no 2365 0.289276628754117 3505 24824903
SGTC_2492 derrusnin 100 µM -0.556841964160089 0.298531595945092 no 2366 0.288817704809703 3406 1715307 Part of coumarin class of compounds.
SGTC_3157 9099274 49.47 µM -0.560182425154019 0.2974540402248 no 2367 0.287677506696645 3474 17217662
SGTC_421 streptovitacin 30 mM -0.561016210705859 0.297185357479669 no 2368 0.287393243122281 3482 91467 include heat shock
SGTC_2972 9093619 59.92 µM -0.561531700494704 0.297019299285803 no 2369 0.28721756302227 3328 25236256
SGTC_1436 4092-1007 8.32 µM -0.561734896041968 0.296953854200729 no 2370 0.287148327484171 3416 2881121
SGTC_2483 5729050 27.16 µM -0.562118257749821 0.296830399287955 no 2371 0.287017724812421 3514 2865180
SGTC_1115 galangin 695.678 nM -0.564259483797045 0.296141287443055 no 2372 0.286288775391977 3524 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2844 9010103 25.97 µM -0.564627581873667 0.296022896235794 no 2373 0.286163550328357 3492 2480525
SGTC_2942 9052777 62.25 µM -0.565097676308052 0.295871731586937 no 2374 0.286003664471757 3497 6469503
SGTC_1871 st057448 67.3 µM -0.567571317014086 0.295076886716727 no 2375 0.285163044041198 3570 691747
SGTC_2248 tofa 1.1 µM -0.56820218875001 0.294874328781579 no 2376 0.284948842716098 3394 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2475 5812728 15.03 µM -0.569664810896257 0.294404962240621 no 2377 0.284452530678331 3466 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1673 st016611 27.3 µM -0.569825654803638 0.294353367268636 no 2378 0.284397976678909 3498 5226799
SGTC_425 3825-7017 13.1 µM -0.572338905001555 0.293547718141651 no 2379 0.283546198705507 3527 3397440
SGTC_1640 st009078 66.4 µM -0.572892463080559 0.293370406515312 no 2380 0.28335875402314 3479 690618
SGTC_768 0384-0033 77.3 µM -0.573133675947957 0.293293158522025 no 2381 0.283277093614741 3375 3965305 YMR134W ERG29
SGTC_2034 5197015 53.07 µM -0.573767007273139 0.293090380172899 no 2382 0.283062738830159 3506 780676
SGTC_285 1486-1325 46 µM -0.580194420768985 0.291036156379898 no 2383 0.280891757810986 3514 22310230
SGTC_1140 3229-1848 2.98 µM -0.580240343791338 0.291021503451053 no 2384 0.280876275441422 3492 2849525
SGTC_2348 9022543 33.42 µM -0.580693710038658 0.290876863716024 no 2385 0.280723450855219 3499 3162678 YDL140C RPO21
SGTC_2035 5154463 94.595 µM -0.581560158657661 0.29060052972566 no 2386 0.280431492842639 3503 2769623
SGTC_200 k038-0079 37.545 µM -0.584825485026455 0.289560233699296 no 2387 0.279332533194944 3406 3436683
SGTC_2229 7354935 190 µM -0.585162408236574 0.289452993373851 no 2388 0.279219259434668 3459 318112
SGTC_2892 9047358 58.44 µM -0.585683826780576 0.289287066246513 no 2389 0.279044002269103 3424 6466771
SGTC_795 0685-0265 78 µM -0.586078214392291 0.289161592924511 no 2390 0.278911477788296 3565 302754
SGTC_2287 7945887 168.79 µM -0.58683212607604 0.288921809254489 no 2391 0.278658229129093 3480 1245853
SGTC_3212 9128307 49.47 µM -0.587189339622011 0.288808229189354 no 2392 0.278538275597147 3301 27243542
SGTC_3354 9151612 71.43 µM -0.58876621157777 0.288307096372658 no 2393 0.278009057380019 3502 27261949
SGTC_2380 9035439 200 µM -0.58971779743763 0.288004879152062 no 2394 0.277689930651744 3573 6462575
SGTC_116 0155-0182 31.788 µM -0.590280508663967 0.287826236270145 no 2395 0.277501302328541 3462 771486
SGTC_1575 cyproterone acetate 48 µM -0.590466653945055 0.287767152598006 no 2396 0.277438917729601 3431 9880 An androgen receptor antagonist and liver toxin.
SGTC_1182 1222-0449 220 µM -0.59156565864605 0.287418438488209 no 2397 0.277070737851674 3478 658318
SGTC_1480 1070-0044 41.2 µM -0.592974037368213 0.286971852430864 no 2398 0.276599263781577 3481 3124987
SGTC_1376 2910-0861 41.3 µM -0.593480947606615 0.286811195577772 no 2399 0.276429664926217 3499 1112859
SGTC_1174 0739-0097 51.1 µM -0.593608846532295 0.28677066685507 no 2400 0.276386881362531 3477 728447
SGTC_3034 9090421 49.47 µM -0.594034105581878 0.286635929921205 no 2401 0.276244651001936 3457 17173761
SGTC_435 c-PAF 6.7 µM -0.594640321670102 0.286443911390202 no 2402 0.276041960620751 3460 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_384 k007-0144 5.16 µM -0.595391093917203 0.286206189442381 no 2403 0.275791038668152 3489 6824886
SGTC_1891 st059073 26.2 µM -0.598072203140261 0.285358017874391 no 2404 0.274895878357007 3553 688754
SGTC_2473 5854593 8.94 µM -0.599768148675025 0.284822122703742 no 2405 0.274330381689075 3470 2872951
SGTC_2233 sulbentine 40.3845 µM -0.599890013351697 0.284783633662853 no 2406 0.274289769216542 3492 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_193 1273-0060 1.558 µM -0.600732607971749 0.284517581339582 no 2407 0.274009048417518 3447 2847393 YHR072W ERG7
SGTC_2704 st078022 71.1 µM -0.601521931730229 0.284268457231229 no 2408 0.273746204330886 3564 54697681
SGTC_230 MPP+ 141.667 µM -0.601623738197653 0.284236332958491 no 2409 0.273712311952544 3498 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_131 0141-0277 33.849 µM -0.60405632115373 0.283469266168592 no 2410 0.27290309894815 3517 1547771
SGTC_1931 st074438 57.1 µM -0.605872255429138 0.282897294872744 no 2411 0.272299792151496 3494 2787313
SGTC_50 0929-0078 56.389 µM -0.607146695963342 0.282496211034897 no 2412 0.2718767816028 3411 1377751
SGTC_2127 5253358 187.912 µM -0.607219037851026 0.282473452258573 no 2413 0.271852779792168 3476 20612
SGTC_1356 1502-0781 85.8 µM -0.607323740030953 0.28244051448768 no 2414 0.271818043252998 3498 567702
SGTC_2767 sibutramine 71.45 µM -0.609300262890529 0.281819076186342 no 2415 0.271162716436917 3601 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1734 st037168 69.4 µM -0.610718720742211 0.281373505547779 no 2416 0.270692905118178 3478 708907
SGTC_2100 5377183 190 µM -0.611092448900161 0.281256165448452 no 2417 0.270569189277417 3550 2844202
SGTC_237 nikkomycin 200 µM -0.611312136307895 0.281187200827109 no 2418 0.270496478980785 3580 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1413 3910-0535 34.4 µM -0.611466844329902 0.281138639539075 no 2419 0.270445280875601 3533 2876951
SGTC_1298 1079-1278 263 µM -0.611893953255175 0.281004595386541 no 2420 0.270303961262898 3538 2840950
SGTC_2879 9041815 71.43 µM -0.612740730070302 0.280738933724697 no 2421 0.270023893287172 3496 4942971
SGTC_550 4123-0385 25.7 µM -0.615009241369668 0.280027826508925 no 2422 0.269274308703824 3528 5731123
SGTC_2297 7971671 152.32 µM -0.615722224905267 0.279804508987468 no 2423 0.269038933161915 3573 909016
SGTC_130 0136-0219 337.655 µM -0.616308323415396 0.279620998551033 no 2424 0.26884552323108 3516 234244
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.618069685860732 0.279069858833106 no 2425 0.268264701918371 3520 2724 A muscle relaxant with antifungal properties.
SGTC_1951 sophoraflavanone G 9.2 µM -0.618186456196876 0.279033339450138 no 2426 0.268226218426102 3520 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2731 amoxapine 43.43 µM -0.619280899596414 0.278691170355591 no 2427 0.267865662544531 3582 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2234 tolnaftate 200 µM -0.619848212360149 0.278513884922623 no 2428 0.267678861876458 3510 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_875 0709-0210 25.7 µM -0.621935474846291 0.277862087992711 no 2429 0.266992148712257 3577 6251364
SGTC_703 3875-0075 71.8 µM -0.623615923771806 0.277337869850246 no 2430 0.266439925208073 3581 2850814
SGTC_2541 muurolladie-3-one 83.07 µM -0.632018098761089 0.274724078535869 no 2431 0.263687525411333 3588 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2912 7964298 10.93 µM -0.632249202647239 0.274652357561483 no 2432 0.263612025436546 3573 2975850
SGTC_673 1082-0474 110 µM -0.632298726634506 0.274636989447188 no 2433 0.263595847741783 3579 3098046
SGTC_1815 st051655 58.2 µM -0.633068355282225 0.274398215443607 no 2434 0.263344503031845 3543 5984156
SGTC_893 0958-0369 48.9 µM -0.634240738934141 0.27403468546142 no 2435 0.26296186224543 3559 6819948
SGTC_1323 1348-1351 11.2 µM -0.634493774139098 0.273956256134158 no 2436 0.262879314307847 3515 6989654
SGTC_2206 7254556 146.969 µM -0.636817760167126 0.273236446207672 no 2437 0.262121778118131 3556 4398905
SGTC_2452 5863136 48.41 µM -0.637191066573198 0.273120909134753 no 2438 0.262000197970274 3558 2184096
SGTC_2258 7960471 200 µM -0.638048692366496 0.272855568583899 no 2439 0.261720991998575 3527 2974708
SGTC_2295 7971645 200 µM -0.638657221962666 0.27266737339851 no 2440 0.261522973637747 3546 2978226 YKL099C UTP11
SGTC_2908 7930301 100 µM -0.639380571417638 0.272443752604316 no 2441 0.261287692454266 3523 2223178
SGTC_3053 9095903 49.47 µM -0.640804532515178 0.272003806625071 no 2442 0.26082484387784 3624 17174018
SGTC_1987 st072290 61.9 µM -0.642727110778353 0.271410369335518 no 2443 0.260200593146373 3561 54697379
SGTC_2563 tomatine 8.54 µM -0.642950145187546 0.27134156765811 no 2444 0.2601282249609 3601 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_378 3970-0959 8.33 µM -0.643631593740427 0.271131408199833 no 2445 0.259907179001415 3586 6615653
SGTC_1267 0828-0272 9.49 µM -0.644566226503779 0.270843298531227 no 2446 0.259604163662365 3630 745334
SGTC_2687 chenodiol 100 µM -0.645126673818309 0.270670608494264 no 2447 0.259422549721912 3593 5702181 A cholesterol synthesis inhibitor.
SGTC_258 haloperidol 50.781 µM -0.645498296558912 0.270556131098708 no 2448 0.259302160914942 3548 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1758 st042942 75.2445 µM -0.647265532959232 0.270012069845472 no 2449 0.258730052305042 3566 669317
SGTC_967 1306-0166 352 µM -0.647630565776525 0.269899759129709 no 2450 0.258611961456022 3584 4437607
SGTC_2596 sinensetin 100 µM -0.647713310168771 0.269874304171738 no 2451 0.258585196906268 3550 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_970 1315-0089 19.5 µM -0.648424872786908 0.269655453196799 no 2452 0.258355093660422 3554 6811083 YLR033W RSC58
SGTC_2225 6654152 15.4 µM -0.648919291648117 0.269503440169135 no 2453 0.258195272286135 3560 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3110 9122132 49.47 µM -0.649278582937483 0.269393000144391 no 2454 0.258079163193957 3664 918317
SGTC_1812 st052057 4.327 µM -0.652217072155198 0.26849061108727 no 2455 0.25713057406947 3607 3645418
SGTC_2314 7727897 200 µM -0.652681591085353 0.268348099867458 no 2456 0.256980786406994 3573 900724
SGTC_2401 5128683 200 µM -0.655790190010358 0.267395383324477 no 2457 0.255979564606696 3546 708373
SGTC_1306 1185-0270 9.02 µM -0.656135078957686 0.267289787764613 no 2458 0.255868607860832 3605 1548076
SGTC_275 trichlorophene 5.69 µM -0.656412002987099 0.267205016435956 no 2459 0.255779534777731 3623 62616
SGTC_248 streptozotocin 5.23457 mM -0.658890654568825 0.266446862260957 no 2460 0.254982993731995 3633 5300 DNA alkylating agent.
SGTC_2526 patulin 37.61 µM -0.65992000762474 0.266132330406302 no 2461 0.254652582006655 3639 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2306 7482397 179.52 µM -0.659964956348429 0.266118600040211 no 2462 0.254638159040709 3621 891448
SGTC_2188 6126565 140.678 µM -0.661085499483791 0.265776426709633 no 2463 0.254278741981876 3573 874518
SGTC_1338 1486-1223 76 µM -0.66118237086257 0.265746856172352 no 2464 0.254247682736148 3618 3444526
SGTC_2531 methyl deoxycholate 70.07 µM -0.662017046893999 0.26549213570173 no 2465 0.253980148370892 3593 16667744 Haematoxylin.
SGTC_2272 7805186 180 µM -0.662226692810784 0.26542817692662 no 2466 0.253912974874045 3596 2956062 YPR165W RHO1
SGTC_3066 9117245 49.47 µM -0.662642410355275 0.265301372948397 no 2467 0.25377980071405 3655 17176980
SGTC_214 4373-3496 70 µM -0.662649181391157 0.265299307872047 no 2468 0.253777631931817 3682 3779166
SGTC_623 k072-0108 16.9 µM -0.663021964710254 0.265185626485178 no 2469 0.253658243381604 3592 5382803
SGTC_1965 Pectolinarigenin 58.4 µM -0.665187620278961 0.264525692991488 no 2470 0.252965248808906 3619 5320438 An anti-inflammatory.
SGTC_2151 5563267 85.4165 µM -0.665694903826855 0.264371230932674 no 2471 0.252803065774813 3627 5310824
SGTC_1947 st076332 61.6 µM -0.666323403172102 0.264179923745807 no 2472 0.252602204931268 3592 24208416
SGTC_2155 5570423 76 µM -0.666610932076975 0.264092427126914 no 2473 0.252510342181205 3585 797402
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.668467877405707 0.263527704302121 no 2474 0.251917490009546 3639 442882
SGTC_3039 9090270 49.47 µM -0.670785080831344 0.262823875948705 no 2475 0.251178726503985 3616 17173750
SGTC_2924 9010168 62.78 µM -0.671009746056749 0.262755687194611 no 2476 0.251107160425104 3654 2993929
SGTC_611 3453-1652 23.7 µM -0.671179665194279 0.262704120585602 no 2477 0.251053040626799 3627 1560575
SGTC_926 2268-1401 59.4 µM -0.671763536240784 0.262526968418163 no 2478 0.250867122843378 3623 2931578
SGTC_2484 5809818 12.04 µM -0.672661799760659 0.262254545958844 no 2479 0.250581237741022 3630 2870548
SGTC_1287 0971-0001 34.6 µM -0.673986572824661 0.261853037506983 no 2480 0.250159925110589 3636 4665869
SGTC_362 0310-0100 9.03 µM -0.674307265307283 0.261755890359649 no 2481 0.250057992991144 3659 790235
SGTC_985 1493-0307 8.71 µM -0.675433526861589 0.261414859299589 no 2482 0.249700185366649 3626 3278274
SGTC_958 1222-0007 33 µM -0.677607224546994 0.260757311215137 no 2483 0.249010382090772 3700 7312461
SGTC_31 0508-1974 57.237 µM -0.678399396227609 0.260517889389996 no 2484 0.248759245909971 3610 6810525
SGTC_1961 st076550 68.7 µM -0.678727412333121 0.260418784666842 no 2485 0.248655296948155 3621 1579337
SGTC_289 k017-0060 526 µM -0.679281246590405 0.260251496749751 no 2486 0.248479838283243 3619 5512909
SGTC_2327 6189656 200 µM -0.681062028406932 0.259713979800292 no 2487 0.247916121235514 3684 5349088
SGTC_3006 9075424 71.4286 µM -0.681179747016007 0.259678467435189 no 2488 0.247878880777831 3641 7465181
SGTC_1360 1598-0022 39.8 µM -0.682759055581236 0.259202277333049 no 2489 0.247379553028544 3670 761525
SGTC_1393 3470-5649 58.2 µM -0.683361370205842 0.259020787544779 no 2490 0.247189261782479 3582 4108395
SGTC_1958 st076513 41.9 µM -0.684145415047756 0.258784637195024 no 2491 0.246941673227174 3623 732122 YGL099W LSG1
SGTC_163 TUB2.036 7.546 µM -0.68477208246951 0.258595968279946 no 2492 0.246743877356875 3686 15992207 YJR013W GPI14
SGTC_1546 5-methoxyflavanone 78.7 µM -0.68490954596715 0.258554592076855 no 2493 0.246700500918196 3682 147795
SGTC_1136 pergolide 1.05886 µM -0.685392090908594 0.258409374282307 no 2494 0.246548266782978 3641 47811 A dopamine receptor agonist.
SGTC_1247 0448-0043 5.84 µM -0.685508771578162 0.258374266572713 no 2495 0.246511463715278 3690 3089013 YGL099W LSG1
SGTC_505 gw-5074 63.9 µM -0.687465620083093 0.257785844571895 no 2496 0.245894679272211 3671 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2909 7941780 10.49 µM -0.690007441466 0.257022561712816 no 2497 0.245094753847832 3659 1243215
SGTC_1706 st031321 9.9705 µM -0.690063090284817 0.257005864104239 no 2498 0.245077256523307 3663 6103185
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.690253371747083 0.256948773798131 no 2499 0.245017432540524 3641 5355888
SGTC_1217 1183-1422 255 µM -0.693116218749139 0.256090628495469 no 2500 0.244118310097232 3706 2849664
SGTC_1300 1094-0077 113 µM -0.693127001174635 0.25608739926529 no 2501 0.244114927072421 3625 5532636
SGTC_271 rotenone 740 µM -0.693754504761541 0.255899504714617 no 2502 0.243918089121414 3694 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_244 nsc-207895 1.295 µM -0.694876947537251 0.255563589138648 no 2503 0.243566210280354 3540 42640
SGTC_3342 9147791 14.508 µM -0.695058263897403 0.255509347864985 no 2504 0.243509394459035 3630 1838168
SGTC_2587 piperic acid 92.2 µM -0.696060288960928 0.255209697886429 no 2505 0.243195537170803 3655 5370536
SGTC_219 mitoxanthrone 164.414 µM -0.696931097615809 0.254949436749435 no 2506 0.242922957594813 3658 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3195 9113082 49.47 µM -0.697375829532332 0.254816572013753 no 2507 0.2427838118855 3641 17018038
SGTC_2024 5144227 134 µM -0.698188281006514 0.254573943792814 no 2508 0.242529727168554 3688 3475211
SGTC_2976 9009005 19.48 µM -0.699229753419335 0.254263098490331 no 2509 0.242204229574293 3688 2993148
SGTC_1156 4092-0367 4.88 µM -0.699424566383466 0.254204975321557 no 2510 0.242143369816321 3690 1357585
SGTC_1728 st035614 33.7865 µM -0.701181125843851 0.253681214101393 no 2511 0.241594993540569 3682 15945546
SGTC_493 zm226600 134 µM -0.701260538007765 0.253657548817046 no 2512 0.241570217980317 3691 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1289 0976-0073 69.1 µM -0.701681947767409 0.253531985674775 no 2513 0.241438766715669 3710 3391136
SGTC_1260 0700-1617 7.75 µM -0.704501775234391 0.252692631672573 no 2514 0.240560172457294 3691 2853078
SGTC_1427 4048-4900 550 nM -0.704503539430231 0.252692106997895 no 2515 0.240559623319325 3691 24132586
SGTC_2250 alverine citrate 130 µM -0.705318524561527 0.25244979047332 no 2516 0.240306017405796 3629 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_367 0335-0881 7.1 µM -0.707661344773673 0.251753890946334 no 2517 0.239577793881544 3659 23828853
SGTC_1916 st067606 49.2 µM -0.7087153527508 0.251441144402536 no 2518 0.239250567780467 3714 19590279
SGTC_1286 0929-0070 131 µM -0.71062457287858 0.250875161500444 no 2519 0.238658455789489 3756 1420408
SGTC_2595 hexamethylquercetagetin 100 µM -0.712935196754513 0.250191086598329 no 2520 0.237942929101525 3644 386331
SGTC_3333 9141820 12.094 µM -0.713184371172715 0.250117376063848 no 2521 0.237865838030487 3699 1939433
SGTC_1518 st038567 90.8 µM -0.713980267798556 0.249882011880081 no 2522 0.237619690542516 3690 77966
SGTC_1075 aripiprazole 15.2 µM -0.714606525115284 0.249696896461409 no 2523 0.237426105818586 3723 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1554 st069299 38.7 µM -0.715066257351973 0.249561050566167 no 2524 0.237284051408302 3676 24207999
SGTC_3232 9132874 49.47 µM -0.716029648727479 0.249276506253654 no 2525 0.236986520904539 3693 3784940
SGTC_115 0527-0192 112.043 µM -0.717359650965523 0.248883964518559 no 2526 0.236576104721948 3746 4233931
SGTC_3211 9128781 49.47 µM -0.718956928716424 0.248412973310335 no 2527 0.236083729139517 3723 17194361
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.719781090053011 0.248170137790418 no 2528 0.235829894793079 3692 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1378 2093-0007 380 nM -0.72001463813583 0.248101346901944 no 2529 0.235757991434432 3734 3618014
SGTC_2485 5633444 17.78 µM -0.72165538649622 0.247618356263513 no 2530 0.235253188769969 3717 5724239
SGTC_333 3486-0131 40.1 µM -0.725111585058021 0.246602593096175 no 2531 0.234191788867745 3781 6744690
SGTC_2088 5278280 127.392 µM -0.72694990202555 0.246063229625352 no 2532 0.233628322965844 3772 791502
SGTC_462 ag-879 158 µM -0.727139368496212 0.246007676026029 no 2533 0.233570292010076 3719 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2505 galangin 7.89 µM -0.727999289442505 0.245755622591213 no 2534 0.233307010629027 3647 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_164 4100-3994 89.624 µM -0.728345810097217 0.245654092320239 no 2535 0.233200963218871 3732 4615967
SGTC_520 3584-0023 682 µM -0.72842618430787 0.245630545960461 no 2536 0.233176369729507 3739 1340790
SGTC_501 nsc-95397 161 µM -0.728819925833288 0.245515213297133 no 2537 0.233055910620291 3729 262093
SGTC_3307 9126885 69.2785 µM -0.729389285220042 0.245348491052777 no 2538 0.232881785078521 3717 24824909
SGTC_2217 6934799 96.0675 µM -0.72960453946347 0.245285475242389 no 2539 0.232815973324797 3665 675606
SGTC_2177 5811945 192 µM -0.729892276506232 0.245201253639013 no 2540 0.232728016847779 3748 5343475
SGTC_781 4335-2806 94.4 µM -0.730078328575932 0.245146803849226 no 2541 0.23267115362554 3849 845254
SGTC_2499 avocadenofuran 51.48 µM -0.73068362678356 0.244969702954064 no 2542 0.232486209359478 3723 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1210 3013-0140 750 nM -0.731077559560525 0.244854481304079 no 2543 0.232365890122215 3760 905973
SGTC_2029 5175081 200 µM -0.731541134786404 0.244718927256736 no 2544 0.232224344306101 3731 1380876
SGTC_2549 cedrol 20.94 µM -0.731953647374207 0.244598338418801 no 2545 0.232098430063303 3669 6708665 A sedative which affects the nervous system.
SGTC_713 1488-1073 324 µM -0.732215032358028 0.244521944926371 no 2546 0.232018665281243 3703 3312542
SGTC_2131 toluylene red 5.2905 µM -0.732359589429529 0.24447970157917 no 2547 0.231974558501708 3736 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2610 ononetin 44.17 µM -0.732545248843833 0.244425452823336 no 2548 0.231917917559613 3745 259632
SGTC_485 niflumic acid 177 µM -0.733879190905344 0.24403587238864 no 2549 0.231511185293482 3751 4488 A COX2 inhibitor.
SGTC_1332 1480-0653 17.5 µM -0.734664095581574 0.243806796031713 no 2550 0.231272045973525 3687 5749438
SGTC_3186 9110464 49.47 µM -0.73599391461608 0.243418950123124 no 2551 0.230867200597037 3714 17018021
SGTC_1694 st024011 44.9 µM -0.736108145654734 0.2433856498356 no 2552 0.230832442972488 3777 2787533
SGTC_3056 9094900 49.47 µM -0.737083605234705 0.243101387091184 no 2553 0.230535754275499 3711 25236784
SGTC_1237 0330-0133 46.1 µM -0.739507837954941 0.242395709535815 no 2554 0.229799341042967 3673 X1237 YHR072W ERG7
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.74078433491161 0.242024576541368 no 2555 0.229412107425339 3716 15053
SGTC_1726 st035556 14.5795 µM -0.740970175390551 0.241970570369984 no 2556 0.229355762026823 3867 5919439
SGTC_687 k029-0044 34.9 µM -0.741147219796233 0.24191912646198 no 2557 0.229302090746024 3754 5829338
SGTC_845 0330-0138 4.51 µM -0.742942783827833 0.241397723641087 no 2558 0.228758160785587 3689 9039800
SGTC_1018 4259-0013 28.1 µM -0.743097477171454 0.241352831771153 no 2559 0.228711333468168 3816 6801262
SGTC_1913 st060213 96.1 µM -0.744619559788542 0.240911366728268 no 2560 0.228250870012414 3756 688959
SGTC_150 3970-0969 77.2 µM -0.747232036662233 0.240154668646324 no 2561 0.227461754482024 3848 6615640
SGTC_1846 st056244 14.8 µM -0.749687325232825 0.239444682351623 no 2562 0.226721521493004 3784 5393182
SGTC_1090 efavirenz 20.7 µM -0.749938579406871 0.239372092859069 no 2563 0.226645848842573 3819 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3061 glucosamine 200 µM -0.751189318590977 0.239010922451117 no 2564 0.226269363799443 3674 91431 and experimental redox chemotherapeutic
SGTC_1781 st038725 66.3 µM -0.751762048730382 0.238845637209514 no 2565 0.226097084282865 3775 4270275 YIL048W NEO1
SGTC_2850 9015429 58.44 µM -0.754225964578775 0.238135284728944 no 2566 0.225356774634901 3814 6457570
SGTC_3341 9147222 25.867 µM -0.755104554213321 0.237882265651067 no 2567 0.225093125401098 3758 1939759
SGTC_1030 k029-0042 36.7 µM -0.755213101925926 0.237851015965098 no 2568 0.225060564283571 3770 6080581
SGTC_2063 5246145 200 µM -0.755358753133685 0.237809088130456 no 2569 0.225016877403675 3796 711240
SGTC_1330 1469-0054 61.8 µM -0.755968102757298 0.237633721872647 no 2570 0.22483416012196 3794 7102664
SGTC_1232 0279-0259 161 µM -0.757605823739354 0.237162749870979 no 2571 0.224343496367965 3788 1560000
SGTC_1924 st058459 75.1 µM -0.75761515477821 0.237160067942485 no 2572 0.224340702516787 3712 688683
SGTC_2283 7944793 200 µM -0.758264114693765 0.236973584674742 no 2573 0.224146442769752 3798 2970533
SGTC_2215 7188065 200 µM -0.758487049382379 0.236909541403931 no 2574 0.224079731522939 3755 940217
SGTC_654 1124-0271 80.9 µM -0.759868991598429 0.236512758143979 no 2575 0.223666449182957 3767 5403748
SGTC_2190 6049624 200 µM -0.760014284757204 0.236471062827744 no 2576 0.223623023141023 3669 2265554
SGTC_992 3909-8734 162 µM -0.760622709798636 0.236296504788317 no 2577 0.223441225706399 3794 4288319
SGTC_784 4579-0127 173 µM -0.76152701562807 0.236037189264863 no 2578 0.223171174501388 3888 1948547
SGTC_846 0335-0850 148 µM -0.762163221785894 0.235854847053819 no 2579 0.222981296811848 3786 6819598
SGTC_740 k014-0057 261 µM -0.76350682482742 0.235470014044111 no 2580 0.222580596850811 3788 4012779
SGTC_2811 7967822 32.47 µM -0.76371346425969 0.235410859408371 no 2581 0.222519007644007 3830 2232244
SGTC_2872 9044037 25.97 µM -0.764627042624623 0.235149427795407 no 2582 0.222246830662581 3770 6465195
SGTC_2801 7907800 81.82 µM -0.764685953630974 0.235132575195947 no 2583 0.222229286178118 3842 6620925
SGTC_1716 st033144 30.6155 µM -0.765128961523529 0.235005865842223 no 2584 0.222097377831171 3769 674617
SGTC_1295 1013-0063 9.78 µM -0.765553271043187 0.234884539985444 no 2585 0.221971078953935 3772 6826038
SGTC_2760 etidronate 98.04 µM -0.765774380495032 0.234821330300067 no 2586 0.2219052803412 3785 3305 A chelator and antioxidant.
SGTC_2003 4023581 200 µM -0.765983333654303 0.234761604438296 no 2587 0.221843109483595 3821 16641307
SGTC_2607 solasodine 47.35 µM -0.766392602200044 0.234644646019164 no 2588 0.221721366638329 3816 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_56 0957-0365 83.25 µM -0.766438692429227 0.234631476636696 no 2589 0.221707658825171 3740 6752360
SGTC_2566 crystal violet carbinol 226 nM -0.766516674443134 0.234609195730743 no 2590 0.221684467097336 3778 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1977 st070720 65.3 µM -0.766937336521971 0.234489024966057 no 2591 0.221559386768503 3810 682188
SGTC_2116 5511452 16.8835 µM -0.769148179119473 0.233858012478672 no 2592 0.220902674790947 3814 870744
SGTC_1296 1068-0102 11.9 µM -0.77023955339488 0.233546862733426 no 2593 0.220578902615293 3798 767053
SGTC_728 3030-5151 22.5 µM -0.770242425475526 0.233546044209028 no 2594 0.220578050929317 3812 3125388
SGTC_2963 9082507 9 µM -0.770304319754621 0.233528405126612 no 2595 0.220559697275255 3813 16459611
SGTC_1946 st076057 65.1 µM -0.770628486545879 0.233436033783286 no 2596 0.220463585638665 3676 953009
SGTC_1683 st010134 710 nM -0.770744908663098 0.233402864242656 no 2597 0.220429073710736 3800 3818134
SGTC_3338 9144300 39.5675 µM -0.770945841093588 0.233345623226675 no 2598 0.220369517007461 3819 4901274
SGTC_3347 9188721 44.724 µM -0.77214415572886 0.233004412815914 no 2599 0.220014526170321 3831 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1702 st027038 51 µM -0.772915095620418 0.232785040469652 no 2600 0.219786315121301 3810 5521182
SGTC_1325 1431-0015 227 µM -0.773143676992359 0.232720019290628 no 2601 0.21971867735431 3748 1103340
SGTC_1036 k216-0215 33.5 µM -0.773390380584289 0.232649854477452 no 2602 0.219645690590998 3784 622330
SGTC_1087 pterostilbene 9.05 µM -0.773807142770322 0.232531350122687 no 2603 0.21952242396459 3824 5281727 Similar to reservatol, lowers cholesterol.
SGTC_44 0929-0055 61.211 µM -0.775129503101422 0.232155565510168 no 2604 0.219131569845104 3758 1379590
SGTC_694 1315-0438 43.2 µM -0.775288074903146 0.232110525731806 no 2605 0.2190847271708 3754 6793154
SGTC_100 0086-0128 49.5915 µM -0.77561397554587 0.232017974150865 no 2606 0.21898847304124 3816 93297
SGTC_917 harmaline 728.087 nM -0.777120526013769 0.231590400380989 no 2607 0.218543832477748 3814 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1564 D-Arginine 115 µM -0.779029426654004 0.231049267046838 no 2608 0.217981190308886 3792 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_770 0389-1121 67.2 µM -0.779041887888531 0.231045736868021 no 2609 0.217977520146982 3929 6753108
SGTC_1704 st028805 70.8 µM -0.779104682396966 0.231027948089988 no 2610 0.217959026051846 3823 2876101
SGTC_1757 st041620 31.8375 µM -0.779405069634215 0.23094286329699 no 2611 0.217870569205821 3869 5289815
SGTC_301 4119-0100 24.5 µM -0.780672128647541 0.230584160975593 no 2612 0.217497678602115 3827 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1457 k015-0032 57.3 µM -0.780883039981269 0.230524482564078 no 2613 0.217435643990952 3803 4302660
SGTC_684 1140-0066 328 µM -0.781616447100532 0.230317028584389 no 2614 0.217220009060722 3828 6813534
SGTC_2928 9011484 9.79 µM -0.782205372327706 0.230150518834965 no 2615 0.217046943869284 3831 2994751
SGTC_3277 9138724 49.47 µM -0.783203818706652 0.229868377070147 no 2616 0.216753716398506 3751 15943418
SGTC_217 ketoconazole 989 nM -0.783894932132814 0.229673195150652 no 2617 0.216550881851894 3713 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1652 st011932 78 µM -0.788551196995981 0.228360610753001 no 2618 0.21518718216614 3742 1551076
SGTC_752 1896-0090 130 µM -0.789385859869732 0.228125768643546 no 2619 0.214943258901727 3792 772567
SGTC_171 k064-0041 9.68 µM -0.794294925778305 0.226747297319003 no 2620 0.213511878679033 3827 53325
SGTC_1256 0570-0116 285 µM -0.794372390080597 0.226725582988636 no 2621 0.213489336330407 3846 410638
SGTC_262 fenpropimorph 62.5 µM -0.795394461353576 0.22643919197747 no 2622 0.213192040374377 3774 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1911 st060208 74.3 µM -0.796419901479795 0.226152062398718 no 2623 0.212894007284301 3888 688783
SGTC_968 1309-0633 340 µM -0.798532438260082 0.225561188051009 no 2624 0.212280788335382 3852 3761976
SGTC_3146 9095609 49.47 µM -0.799312711605019 0.225343167548799 no 2625 0.212054554956185 3899 17173999
SGTC_104 0074-0074 590.992 µM -0.800169540074347 0.225103893875056 no 2626 0.211806287586827 3657 3943124
SGTC_2438 5259590 200 µM -0.800908117994368 0.224897757834537 no 2627 0.211592420045453 3859 1201127
SGTC_1446 4239-0190 62 µM -0.801607164173362 0.224702753653134 no 2628 0.211390116077086 3847 1340085
SGTC_2252 omeprazole 400 µM -0.803183020501409 0.224263508632708 no 2629 0.210934479007907 3778 4594 A proton pump inhibitor.
SGTC_3202 9113761 49.47 µM -0.805709124939233 0.223560415088657 no 2630 0.210205293420105 3893 4798415
SGTC_370 0180-0345 38.7 µM -0.807133937228591 0.223164399081865 no 2631 0.209794660797874 3747 3989527
SGTC_1797 st048695 56.8 µM -0.807513918761298 0.223058853529587 no 2632 0.209685229366485 3806 592262 YIL048W NEO1
SGTC_872 0588-0139 234 µM -0.808018549793738 0.222918728667843 no 2633 0.209539951845371 3824 2047100
SGTC_1527 coumarin 137 µM -0.808428470377286 0.222804939720423 no 2634 0.209421983976992 3961 323 A hepatotoxic, DNA x-linker.
SGTC_2655 perillic acid 100 µM -0.810177001255115 0.222319940754899 no 2635 0.208919226862503 3879 5702197 An apoptosis inducer.
SGTC_2662 daunorubicin 22.37 µM -0.810771309132805 0.222155231783793 no 2636 0.208748506863566 3732 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_556 4058-0063 51.5 µM -0.811291176399849 0.222011210717875 no 2637 0.20859923799783 3902 6615692
SGTC_3012 9080433 71.4286 µM -0.81706352501609 0.220415658229357 no 2638 0.206946063038959 3839 17688859
SGTC_2871 9038510 12.99 µM -0.817239793636352 0.220367038920818 no 2639 0.206895702791035 3817 4945164
SGTC_2395 5646831 180.19 µM -0.817412495460575 0.220319409386955 no 2640 0.206846368618236 3862 6808628
SGTC_2918 7977171 22.06 µM -0.818634689889897 0.219982508410969 no 2641 0.206497434412683 3778 2236483
SGTC_714 4296-0578 26.1 µM -0.819130389495526 0.219845951864626 no 2642 0.206356012562928 3888 1589775
SGTC_57 miconazole 162.5 nM -0.819168403614347 0.219835481650731 no 2643 0.206345169600576 3808 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.821241291642185 0.219264980383817 no 2644 0.20575442043204 3868 641818 YHR062C RPP1
SGTC_26 0302-0163 425.158 µM -0.821584652285788 0.219170562718633 no 2645 0.205656663592727 3904 3100915
SGTC_1802 st050112 57.9 µM -0.822367490448828 0.218955384487876 no 2646 0.20543388796442 3865 4662563
SGTC_531 3788-1495 174 µM -0.822383257472894 0.218951051864685 no 2647 0.205429402547214 3837 2896655
SGTC_2265 7929201 200 µM -0.824032891692913 0.218498021163303 no 2648 0.204960434554315 3834 1265108
SGTC_2738 aclarubicin 5.55 µM -0.824836407996719 0.218277551181379 no 2649 0.204732236779078 3810 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2318 6029776 164 µM -0.825017180709321 0.218227968166505 no 2650 0.204680918353074 3842 818325
SGTC_835 0312-0010 67.2 µM -0.825422791968525 0.218116739216181 no 2651 0.20456579978051 3829 1626196
SGTC_815 1582-0027 36.9 µM -0.826862479725469 0.217722204045291 no 2652 0.204157505926494 3938 3128206
SGTC_2982 9019404 25.97 µM -0.827237181303557 0.217619587571374 no 2653 0.204051320627543 3834 22333232
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.829036319484997 0.217127261122759 no 2654 0.203541927930077 3885 165521
SGTC_1756 st041558 35.5 µM -0.829775467990765 0.216925182944572 no 2655 0.203332871702511 3927 3955792
SGTC_1645 Cervolide 78 µM -0.830039258856532 0.216853090644952 no 2656 0.203258293746773 3869 23173 A fragrance.
SGTC_2788 5282734 71.43 µM -0.830076622967319 0.216842880400546 no 2657 0.2032477316268 3941 743706
SGTC_2326 6164455 177.58 µM -0.830088722323843 0.216839574148671 no 2658 0.203244311440181 3877 2888790
SGTC_408 cantharidin 100 µM -0.830120807518839 0.216830806737907 no 2659 0.203235241921323 3850 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3018 9082602 49.47 µM -0.830323689940884 0.216775373031829 no 2660 0.203177898760417 3871 17332089
SGTC_1143 3454-2408 5.08 µM -0.831566575848139 0.216435957367549 no 2661 0.202826817453942 3801 X1143
SGTC_1474 0330-0125 5.35 µM -0.8317565148871 0.216384114638973 no 2662 0.20277319680816 3871 X1474
SGTC_1229 0139-0193 12.2 µM -0.833011079586301 0.216041869245639 no 2663 0.202419240319612 3916 3090752
SGTC_2409 alverine citrate 63.97 µM -0.834868210100639 0.215535819898722 no 2664 0.201895957752919 4061 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_604 1000-0114 314 µM -0.836718289833972 0.215032376040702 no 2665 0.201375467968336 3877 1572745
SGTC_3198 9112019 49.47 µM -0.838936978547251 0.214429527643125 no 2666 0.200752337781858 3930 45595555
SGTC_1880 MG-132 525 µM -0.839387083147797 0.214307348022401 no 2667 0.200626064936047 3820 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2532 xanthone 78.9 µM -0.841717656212576 0.213675368539835 no 2668 0.199973006427968 3880 7020 An insecticide.
SGTC_9 0092-0002 10.449 µM -0.844225786632944 0.212996455386969 no 2669 0.199271623756671 3862 759368
SGTC_2807 7945238 51.95 µM -0.845076275498473 0.212766526920413 no 2670 0.199034126731906 3962 17148797
SGTC_3013 9080133 71.4286 µM -0.845353287706725 0.212691668355635 no 2671 0.198956808558465 3965 17050193
SGTC_907 3448-6986 75.5 µM -0.845421823880729 0.212673149813808 no 2672 0.198937681899857 3910 590582
SGTC_1786 berberine 21.6 µM -0.848128118933699 0.211942659122366 no 2673 0.19818331165101 3841 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_808 0711-0032 135 µM -0.849350136177024 0.211613290391522 no 2674 0.197843245334739 3845 4252555
SGTC_2544 sphondin 68.51 µM -0.851103530082368 0.211141224165594 no 2675 0.197355922328372 3868 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_587 k089-0003 57 µM -0.851873340345597 0.210934163263566 no 2676 0.197142197517832 3811 9659696
SGTC_1434 4073-0095 163 µM -0.853979950075217 0.210368143714004 no 2677 0.196558049353687 3862 24133745
SGTC_2022 5136654 200 µM -0.856621533774543 0.20965964502226 no 2678 0.195827040470659 3964 1713771
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.857598998058676 0.209397835601527 no 2679 0.195556964253352 3894 688751
SGTC_2998 9066762 71.4286 µM -0.860712566434515 0.20856516367551 no 2680 0.194698185121 3936 4945196
SGTC_2490 carminic acid 95.39 µM -0.863626743961562 0.207787586988667 no 2681 0.193896483876143 3823 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2373 9071805 200 µM -0.86561188971852 0.207258881459973 no 2682 0.193351516592176 3873 10149009
SGTC_2830 7992007 71.43 µM -0.865981766321271 0.20716045991117 no 2683 0.193250080513273 3815 1952075
SGTC_1452 4194-0072 190 µM -0.869639851497336 0.206188558947813 no 2684 0.192248626092958 3967 1343545
SGTC_73 0327-0325 16.231 µM -0.869640395286419 0.206188414672062 no 2685 0.1922484774591 3859 53298
SGTC_3274 9138298 49.47 µM -0.87089304621976 0.205856225663485 no 2686 0.191906277001165 3880 17015756
SGTC_1040 k898-0338 155 µM -0.872212415304178 0.205506687310144 no 2687 0.191546253862635 3908 20969351
SGTC_2855 9016525 58.44 µM -0.872807952578144 0.205349028069449 no 2688 0.191383882117037 3894 43811474
SGTC_2884 9058502 51.95 µM -0.873045268771194 0.2052862223181 no 2689 0.191319201961963 3963 6471554
SGTC_103 0844-0104 51.839 µM -0.873165023685369 0.205254533502118 no 2690 0.19128656803535 3898 5375804
SGTC_350 k064-0020 19.8 µM -0.873592325909153 0.205141487077163 no 2691 0.191170153446978 3923 2790705
SGTC_3233 9132340 49.47 µM -0.874687844009998 0.20485182755935 no 2692 0.190871888047408 3936 17682950
SGTC_95 0471-0001 561.058 µM -0.874815136180919 0.204818186761574 no 2693 0.190837250046047 3929 4015405
SGTC_539 4859-0462 2.54 µM -0.875493041053242 0.204639085285926 no 2694 0.19065284750434 3986 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_930 2810-3379 265 µM -0.875563438350911 0.204620491764703 no 2695 0.190633704420475 3979 1015764
SGTC_2996 9066192 71.4286 µM -0.877463037568119 0.204119144172141 no 2696 0.190117593394792 4006 6472854
SGTC_791 1348-1292 225 µM -0.877577882393384 0.204088857474485 no 2697 0.190086418214977 3913 5437054
SGTC_426 0988-0037 14.6 µM -0.877939559263961 0.203993494107604 no 2698 0.189988259817953 3947 5383008
SGTC_2938 9059746 27.26 µM -0.878135376382831 0.203941874073883 no 2699 0.189935128437342 3967 6471769
SGTC_1982 st072467 71.9 µM -0.878468137628029 0.203854171575908 no 2700 0.189844860734713 3919 3163533
SGTC_3220 9131269 49.47 µM -0.878750515726654 0.203779765685678 no 2701 0.189768281095121 3967 17722206
SGTC_1085 doxorubicin 7.67 µM -0.879868313603108 0.203485387791172 no 2702 0.189465325943922 3955 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_503 tyrphostin 8 294 µM -0.880278183657159 0.203377509969261 no 2703 0.189354314069556 3923 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1650 st011916 45.8 µM -0.881659192678859 0.203014279584117 no 2704 0.188980567397542 3866 242528
SGTC_2163 5671233 125 µM -0.883669333410679 0.202486269017402 no 2705 0.188437369696814 3935 701023
SGTC_853 0419-0306 21 µM -0.883907850036849 0.202423671573351 no 2706 0.188372979631999 3963 762713
SGTC_986 1493-0483 84 µM -0.88520979075088 0.20208218804278 no 2707 0.188021746363532 3867 40079
SGTC_2521 angolensin 13.4 µM -0.885890570202738 0.201903765048919 no 2708 0.18783824900068 4027 821428 A flavenoid.
SGTC_1976 st070609 63.5 µM -0.886035374978088 0.201865825862543 no 2709 0.18779923257493 3853 682556
SGTC_3172 9105863 49.47 µM -0.889172379152965 0.201044971745315 no 2710 0.186955222359973 3967 2348785
SGTC_2180 6301957 200 µM -0.89049960596244 0.200698282341193 no 2711 0.186598839948666 3952 845462
SGTC_873 0591-4978 488 µM -0.890869953537149 0.200601606678821 no 2712 0.186499470596981 4056 3305145
SGTC_1447 4239-0816 81.9 µM -0.892139122401667 0.200270514547174 no 2713 0.186159183790588 3967 1341554
SGTC_947 3447-0010 211 µM -0.892963921641033 0.200055522679021 no 2714 0.18593824684167 3920 748350
SGTC_356 1634-0012 32.5 µM -0.893623715969634 0.199883640858866 no 2715 0.185761626458253 3958 735457
SGTC_351 caspofungin 25 nM -0.8948883673042 0.199554437197827 no 2716 0.185423382888082 3969 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_564 3555-0129 330 µM -0.895412147854795 0.199418186558795 no 2717 0.185283404607381 3811 563260
SGTC_2277 7947813 106.88 µM -0.895535071576071 0.19938621862005 no 2718 0.185250563237924 4051 1246798
SGTC_891 0929-0073 133 µM -0.896036284719582 0.199255903457795 no 2719 0.185116692201618 4032 5603632
SGTC_1084 voriconazole 435 nM -0.901076950371868 0.197948186979336 no 2720 0.183773703623627 3956 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2179 6298986 200 µM -0.901218215598748 0.197911612910158 no 2721 0.183736153857548 3927 738374
SGTC_1088 bifonazole 369 nM -0.901567323542091 0.197821245133854 no 2722 0.183643377840356 3917 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_802 4112-3352 742 µM -0.901591111666681 0.197815088404422 no 2723 0.183637057169104 4045 704594
SGTC_2986 9022445 71.43 µM -0.902738598616558 0.197518238784831 no 2724 0.183332322849761 3984 6459286
SGTC_1657 st012939 43.4 µM -0.904976316167792 0.196940126757556 no 2725 0.182738967208235 3998 24207257
SGTC_861 0443-0273 110 µM -0.90502696818996 0.196927052726384 no 2726 0.182725550153558 3991 6149169
SGTC_396 dithiazanine 1.25 µM -0.907149281015612 0.196379724945047 no 2727 0.182163930236499 3974 10578 An antihelmenthic.
SGTC_3097 9117246 49.47 µM -0.908688217063403 0.195983422748093 no 2728 0.181757362804091 3996 16423892
SGTC_353 1988-1175 58.3 µM -0.909205784386799 0.195850249463392 no 2729 0.181620755727638 3823 2788357
SGTC_366 0181-0206 4.31 µM -0.909330360261383 0.195818203519066 no 2730 0.181587884681369 3962 274874
SGTC_1003 4049-0218 100 µM -0.909468171971648 0.195782756490977 no 2731 0.181551525516917 4018 295161
SGTC_360 0957-0399 1.01 µM -0.910710466282394 0.195463397476302 no 2732 0.181223973991914 4002 6752301 YPR165W RHO1
SGTC_1112 tnp00069 1.16933 µM -0.911205757803491 0.195336160189687 no 2733 0.181093485420856 3996 145826
SGTC_3162 9099653 49.47 µM -0.911312407410635 0.195308769159693 no 2734 0.181065395420038 3954 25237511
SGTC_547 1120-0019 610 nM -0.911382755376086 0.195290702829668 no 2735 0.181046868253389 3923 3676939
SGTC_1470 k295-0292 231 µM -0.911892375885124 0.195159855561453 no 2736 0.18091268770243 4057 5045612
SGTC_2443 5493264 126.67 µM -0.911954017979163 0.195144032300402 no 2737 0.180896461871241 4014 5340055
SGTC_192 3455-0609 60.9 µM -0.914479725112863 0.194496364803607 no 2738 0.180232413330137 4049 3769639
SGTC_1630 st005209 31.3 µM -0.914506551704822 0.194489492685723 no 2739 0.180225368413942 3926 3367314
SGTC_1102 cgs 12066b 26.1 µM -0.915094435013727 0.194338932826908 no 2740 0.180071028104328 3996 6438352 A 5-HT1B full agonist.
SGTC_1111 tnp00062 510.699 nM -0.916315246844088 0.194026503584083 no 2741 0.179750786690344 4041 676306
SGTC_2075 5212009 200 µM -0.916869439945062 0.193884775955563 no 2742 0.179605529792147 3883 780898
SGTC_2650 prasterone 100 µM -0.918198376910363 0.193545174881905 no 2743 0.179257509132081 3964 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1068 loratadine 26.9 µM -0.918491345361078 0.19347035756312 no 2744 0.17918084394273 4031 3957 A H1 histamine antagonist.
SGTC_894 0960-0238 55.9 µM -0.918842816771952 0.193380623234105 no 2745 0.179088896674954 3974 6741907 YDL195W SEC31
SGTC_326 k292-0812 17.5 µM -0.922712226481721 0.192394401997612 no 2746 0.178078596271966 3976 3579357
SGTC_1985 st071382 65.5 µM -0.923307689649336 0.192242906009799 no 2747 0.177923440854335 3982 6123237
SGTC_897 1000-0139 31.4 µM -0.931807258587028 0.190088432607281 no 2748 0.175718071369743 3949 6151020
SGTC_933 2914-0560 114 µM -0.933308604237567 0.189709418872468 no 2749 0.175330326957152 4071 463887
SGTC_1489 4065-0444 182 µM -0.933847712939403 0.189573434727127 no 2750 0.175191226748369 3969 2877968
SGTC_431 k089-0097 107 µM -0.934610064038468 0.189381242573044 no 2751 0.174994645295238 3859 5499420
SGTC_38 0929-0051 58.268 µM -0.935712821779759 0.189103444664615 no 2752 0.174710533627474 4025 1379719
SGTC_2328 6201408 200 µM -0.936531507835638 0.188897370226758 no 2753 0.174499798970158 4022 2890418
SGTC_1388 3346-4487 254 µM -0.936961994601939 0.188789066369024 no 2754 0.17438905390927 4077 3345614
SGTC_374 0880-0231 82.3 µM -0.938181372288115 0.188482497453136 no 2755 0.174075604791609 3935 6833587
SGTC_2273 7815444 169.05 µM -0.939869119059656 0.188058680751149 no 2756 0.173642349607654 3984 2824616
SGTC_537 1334-0398 209 µM -0.939976782404027 0.188031664960815 no 2757 0.173614735050496 4053 5846986
SGTC_591 4299-0174 154 µM -0.941552401665404 0.187636571470712 no 2758 0.173210924391641 4009 5509088
SGTC_1647 st011722 22.4 µM -0.941829972623868 0.187567022500445 no 2759 0.17313984859065 3987 2854783
SGTC_1555 citronellol 128 µM -0.942950159156247 0.187286507261744 no 2760 0.172853198452876 3970 8842 A terpine precursor.
SGTC_1832 st054113 55 µM -0.944589946684846 0.186876342457885 no 2761 0.172434130764275 4034 1251267
SGTC_467 ro 31-8220 72.8 µM -0.94461176365332 0.186870889066174 no 2762 0.172428559543964 3964 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1810 st050138 53 µM -0.946865828642307 0.1863079914748 no 2763 0.171853576221426 4019 3444541
SGTC_2313 7726885 200 µM -0.948839774050652 0.185815910697252 no 2764 0.171351054659631 4083 726423
SGTC_2469 5655019 90.81 µM -0.948843098902585 0.185815082532405 no 2765 0.171350209021225 4086 2788239
SGTC_234 nsc-17383 10.7 µM -0.951829800417475 0.185072070173816 no 2766 0.170591653016528 4033 408974
SGTC_2429 5902844 64.44 µM -0.957499680857797 0.183666640134158 no 2767 0.169157553703478 4055 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2783 7738165 71.43 µM -0.95848107826649 0.183424051668974 no 2768 0.168910114189775 4048 17201110
SGTC_3323 9138564 53.9225 µM -0.959726721128194 0.183116433029313 no 2769 0.168596385569108 4071 43912313 YNL103W MET4
SGTC_3335 9143315 29.6265 µM -0.961709539517366 0.182627428988081 no 2770 0.168097764547404 4060 4899691
SGTC_2706 st078239 82.5 µM -0.962832363506331 0.182350879334758 no 2771 0.167815828297726 4012 15434492
SGTC_464 bw-b 70c 158 µM -0.964160339721377 0.182024138968273 no 2772 0.167482772421872 4083 5353454
SGTC_224 benfluorex 43.875 µM -0.964194332745629 0.182015780001984 no 2773 0.167474252579553 4060 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1865 st057639 52.2 µM -0.964260218586537 0.18199957919894 no 2774 0.167457740075614 4024 688818
SGTC_1943 st076331 65.2 µM -0.965121586882431 0.181787858558002 no 2775 0.167241957919479 4069 24208415
SGTC_1705 st027868 56.3335 µM -0.966209456411831 0.181520685153232 no 2776 0.166969690970246 3994 292948
SGTC_1927 st060202 13.8 µM -0.967061698902523 0.181311551938136 no 2777 0.166756595476084 3930 688887
SGTC_1509 1326-1131 80 µM -0.969696571362054 0.180665930996877 no 2778 0.166098879999463 3979 768313
SGTC_2751 anetholtrithion 17.25 µM -0.974146302608604 0.179578894022186 no 2779 0.164991951035727 4082 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1149 3909-7961 23.3 µM -0.97458091757162 0.179472941544035 no 2780 0.164884091504833 4096 735261
SGTC_1883 5-benzylidenerhodanine 20 µM -0.97465404965159 0.17945511692514 no 2781 0.16486594661502 4052 1273210
SGTC_32 0928-0142 34.1 µM -0.974677135259436 0.179449490457782 no 2782 0.164860219085184 4048 2244242
SGTC_824 1304-0008 100 µM -0.976882353250714 0.178912541934689 no 2783 0.164313699552878 4085 768245
SGTC_2339 9000433 200 µM -0.976944408130615 0.178897446833942 no 2784 0.164298337494261 4082 2988954
SGTC_157 1348-1695 65.819 µM -0.978687457139735 0.178473770610883 no 2785 0.163867215704521 4015 5380510
SGTC_205 1486-1330 71.903 µM -0.979331097771297 0.178317483275358 no 2786 0.163708204856215 4085 4118834
SGTC_1230 0170-0365 3.77 µM -0.980181050881876 0.178111231796986 no 2787 0.163498378216013 4112 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1450 4112-4260 37.6 µM -0.980183620007021 0.17811060859553 no 2788 0.163497744244849 4051 1633175
SGTC_2915 7971052 15.16 µM -0.981030988993063 0.177905134408174 no 2789 0.163288730009494 3978 5741558
SGTC_680 0417-1641 114 µM -0.981161283224144 0.177873553289957 no 2790 0.163256606701845 4045 2835990
SGTC_3131 9127911 49.47 µM -0.981538385668383 0.177782169962408 no 2791 0.16316365736276 4129 45595681
SGTC_281 1672-3440 14.9 µM -0.981981937795303 0.17767472177906 no 2792 0.163054373330989 4114 6833000
SGTC_1907 st060210 83.7 µM -0.9829107365977 0.177449857894898 no 2793 0.162825686571706 4120 688793
SGTC_940 3232-1287 54.8 µM -0.984507654610587 0.177063661314999 no 2794 0.162432984836081 3995 1585493 YIL048W NEO1
SGTC_755 1995-0008 37.3 µM -0.985262901666528 0.176881198443072 no 2795 0.162247475189715 4031 689533
SGTC_2856 9022925 19.48 µM -0.985920058942858 0.176722530159422 no 2796 0.162086171387257 4134 4944862
SGTC_737 1950-0117 57.9 µM -0.986090297829374 0.176681441265977 no 2797 0.162044402112051 4034 5393513
SGTC_1392 3455-1037 33.9 µM -0.987894748373922 0.176246290093517 no 2798 0.161602098850051 4085 981132
SGTC_2786 7743617 45.45 µM -0.988153474117146 0.176183952887009 no 2799 0.16153874509126 4028 583674
SGTC_2036 5160441 105 µM -0.989018114303079 0.175975728324089 no 2800 0.161327139530293 4055 134534 YIL048W NEO1
SGTC_112 phenothiazine 287.218 µM -0.989438514580529 0.175874542923649 no 2801 0.161224319268108 4003 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1033 k072-0102 21.3 µM -0.992533618951428 0.175130722377596 no 2802 0.160468644052912 4063 5965931
SGTC_829 1635-0120 117 µM -0.995521530023976 0.174414558578427 no 2803 0.159741339114482 4097 285054
SGTC_1752 st044819 83.042 µM -0.99604233276016 0.174289919532957 no 2804 0.159614788545391 4084 441209 YML126C ERG13
SGTC_1856 st057054 55.7 µM -0.99736976233577 0.173972493757838 no 2805 0.159292531438667 4107 1266018
SGTC_1709 st033179 39.1045 µM -0.999500092373999 0.173463840727845 no 2806 0.158776247177077 4060 573381
SGTC_3244 9134489 49.47 µM -1.00324040416674 0.172573069298728 no 2807 0.157872441358093 4102 16584271
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.00471889437377 0.172221766256557 no 2808 0.157516113728622 4125 4174840
SGTC_314 1671-0008 2.74 µM -1.00570813876213 0.171986967573216 no 2809 0.157277993485829 3972 3913060
SGTC_2642 cholecalciferol 100 µM -1.0062311547455 0.171862911548065 no 2810 0.157152194406418 4088 9821465 A vitamin D precursor, similar to steriods.
SGTC_491 tetrandrine 80.3 µM -1.00806112265542 0.171429304808546 no 2811 0.156712559991409 4108 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2073 5212005 126 µM -1.00874975426856 0.17126631633606 no 2812 0.156547331855283 3880 691789
SGTC_3322 9139058 2.11 µM -1.01050629027317 0.170851020223794 no 2813 0.156126393639509 4183 4908926 YPR165W RHO1
SGTC_779 1360-0071 233 µM -1.01064941661134 0.170817209417745 no 2814 0.156092127578419 4152 7566
SGTC_1072 oxiconazole 14.9 nM -1.01319298576006 0.170217055125145 no 2815 0.155483995091165 4098 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_249 wiskostatin 11.211 µM -1.0133264285442 0.170185606687694 no 2816 0.155452133964957 4038 2775510 A n-wasp and actin depolymerizer.
SGTC_2102 5377816 72.7585 µM -1.01702783831716 0.169314780190539 no 2817 0.15457009324392 4156 1379702
SGTC_1354 1498-1681 81 µM -1.01748068773868 0.169208435537185 no 2818 0.154462407412808 4123 5754243
SGTC_2286 7945697 125 µM -1.01853728342754 0.16896047724627 no 2819 0.154211345963874 4140 1245733
SGTC_1011 4112-3381 17.4 µM -1.02042628014534 0.168517755880515 no 2820 0.15376316770573 4183 2877139
SGTC_3143 9086658 49.47 µM -1.02045902827091 0.168510087333656 no 2821 0.153755405584995 4168 25236626
SGTC_2143 5623677 140.463 µM -1.02191531945745 0.168169298102681 no 2822 0.15341049057182 4070 5375313
SGTC_3248 9135562 49.47 µM -1.02268962047817 0.167988283261613 no 2823 0.153227310253905 4094 17650701
SGTC_682 0kpi-0099 17 µM -1.02348076508446 0.167803460329174 no 2824 0.153040294926587 4148 1714895 YML126C ERG13
SGTC_1559 coumarin 343 70.1 µM -1.0302665816393 0.166223574797398 no 2825 0.151442440998612 4150 108770 A hepatotoxic, DNA x-linker.
SGTC_1442 4112-3290 3 µM -1.03098041201981 0.166057939877771 no 2826 0.151275002779213 4098 704353
SGTC_849 0386-0493 241 µM -1.03237615808601 0.165734383645792 no 2827 0.150947968238024 4091 726119
SGTC_1410 3909-8106 77.9 µM -1.03262949449034 0.165675699955203 no 2828 0.150888659971934 4187 1039210
SGTC_227 fluconazole 33.516 µM -1.03425373517656 0.165299774688508 no 2829 0.150508779595547 4118 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_169 k015-0017 16.025 µM -1.0361980804813 0.16485048869287 no 2830 0.150054871051413 4083 1840002
SGTC_1465 k213-0056 144 µM -1.0369475937265 0.164677507714454 no 2831 0.149880140717799 4000 24048857 YMR208W ERG12
SGTC_2276 7947513 42.08 µM -1.03961943253708 0.164061828347111 no 2832 0.149258372507745 4083 2105100
SGTC_1626 st003712 1.76 µM -1.03973658133576 0.164034867633029 no 2833 0.149231150079589 4167 24207035
SGTC_2074 5212007 75.395 µM -1.04076356755648 0.163798639292282 no 2834 0.148992646300717 4005 758611
SGTC_2337 9009472 200 µM -1.041860329834 0.163546604935043 no 2835 0.148738219310817 4113 5742383
SGTC_2845 9003024 42.97 µM -1.04474305982633 0.162885359323009 no 2836 0.148070868859394 4211 2990173
SGTC_1893 st059353 36.1 µM -1.04645359246991 0.162493817322962 no 2837 0.147675830198097 4157 3112488
SGTC_2699 st077704 54.6 µM -1.04694050978042 0.162382473721071 no 2838 0.147563508346588 4144 645852
SGTC_487 nimodipine 119 µM -1.04798241803153 0.162144386946594 no 2839 0.147323353747293 4087 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2675 theaflavin digallate 100 µM -1.0489266392901 0.161928819105208 no 2840 0.14710594188362 4077 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2586 curcumin 80 µM -1.04905039172899 0.161900579989395 no 2841 0.147077463192619 4082 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1288 0973-0013 65.5 µM -1.05041389935549 0.161589653104831 no 2842 0.146763928981155 4179 4315430
SGTC_55 0767-0285 6.563 µM -1.05132811596725 0.161381398250247 no 2843 0.146553959105827 4052 3116166
SGTC_966 1300-0360 30.2 µM -1.05424355180238 0.160718443423349 no 2844 0.145885712616556 4124 70588
SGTC_137 0438-0332 85.389 µM -1.05486184498363 0.160578075695869 no 2845 0.145744257351367 4102 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1061 3448-9325 110 µM -1.05657070688897 0.160190538744407 no 2846 0.145353777672733 4079 723482
SGTC_3165 9101544 49.47 µM -1.05748465535908 0.159983523988892 no 2847 0.145145227029912 4164 5002184
SGTC_2748 diazoxide 86.69 µM -1.05836022241955 0.159785367011134 no 2848 0.144945623455255 4203 3019 A potassium channel activatior.
SGTC_548 1436-0017 110 µM -1.0595021556854 0.159527167827871 no 2849 0.144685574008149 4215 9677137
SGTC_3094 9117742 49.47 µM -1.0603632566571 0.159332647526146 no 2850 0.144489685713804 4090 17149698
SGTC_3311 9131146 2.8755 µM -1.06256935781703 0.158835004403683 no 2851 0.143988644586935 4128 4900406 YPR165W RHO1
SGTC_1259 0671-0132 43 µM -1.06261066196915 0.158825696910801 no 2852 0.143979274937025 4072 X1259
SGTC_2546 rhodinyl acetate 100 µM -1.06399839820528 0.158513191697492 no 2853 0.143664712587294 4112 6708682
SGTC_2375 9072683 200 µM -1.06591122913799 0.158083101560401 no 2854 0.143231886198858 4235 16798029
SGTC_1160 4092-0570 10.5 µM -1.06844937666725 0.157513595880501 no 2855 0.142658927073705 4156 4994975
SGTC_1364 1653-0028 37.6 µM -1.06913784259783 0.157359351686927 no 2856 0.142503780948975 4151 5718652
SGTC_415 dibenzyl ketone 100 µM -1.06920590369647 0.157344108644785 no 2857 0.1424884495487 4145 7593
SGTC_620 0109-0052 432 µM -1.06940342098673 0.157299877940616 no 2858 0.14244396324487 4160 493037
SGTC_1326 1431-2094 10.8 µM -1.07009706022824 0.157144613760244 no 2859 0.142287811121565 4142 616278
SGTC_1235 benzylparaben 21.5 µM -1.07104688297597 0.156932169020708 no 2860 0.142074174896664 4186 7180
SGTC_1514 1189-1591 158 µM -1.07116880962664 0.156904911648966 no 2861 0.142046766618306 4186 767698 YMR146C TIF34
SGTC_896 0964-0007 44.5 µM -1.07182477091556 0.156758321363651 no 2862 0.14189937242865 4128 6756758
SGTC_762 1165-0429 115 µM -1.07300009113499 0.156495893363671 no 2863 0.141635537620407 4172 5967793
SGTC_45 0kpi-0036 14.9 µM -1.07312208857737 0.156468670096518 no 2864 0.141608170795882 4204 2795021
SGTC_1067 clotrimazole 1.36 µM -1.073209817175 0.156449095719857 no 2865 0.141588493473658 4195 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3136 9095672 49.47 µM -1.07353242983638 0.15637712688406 no 2866 0.141516148129748 3883 17217380
SGTC_1020 4335-0961 93.3 µM -1.07402565951817 0.156267138747421 no 2867 0.141405590634847 4112 669075
SGTC_2628 lathosterol 100 µM -1.07498190851793 0.156054044467576 no 2868 0.141191414096415 4235 6710616
SGTC_2256 7954252 200 µM -1.07528704381051 0.155986087244068 no 2869 0.141123117518816 4177 2972920
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.07727858326668 0.155543027118196 no 2870 0.140677913627339 4165 390807
SGTC_507 nimesulide 162 µM -1.07933380257954 0.155086671323434 no 2871 0.140219474638758 4236 4495 A COX2 inhibitor.
SGTC_138 0850-0259 40.9225 µM -1.08327381311361 0.1542142771476 no 2872 0.139343452564339 4118 6813004
SGTC_833 3852-0053 558 µM -1.08377021426347 0.154104595046787 no 2873 0.13923334740961 4246 3123681
SGTC_2368 9071271 200 µM -1.08648400334742 0.153505883380637 no 2874 0.138632457208965 4175 27209959
SGTC_2862 9027634 71.43 µM -1.08736610720746 0.153311607279562 no 2875 0.138437521805577 4135 5012562
SGTC_1368 1852-0141 284 µM -1.08933860981128 0.152877769503626 no 2876 0.13800229623865 4206 2838987
SGTC_1928 4'-methoxychalcone 40.3 µM -1.09028169259072 0.152670633152376 no 2877 0.137794538547801 4220 641818
SGTC_1632 st005650 90 µM -1.09190134306649 0.152315331775758 no 2878 0.137438233661429 4212 2759605
SGTC_1057 3448-5381 134 µM -1.09335784593463 0.15199628906313 no 2879 0.137118357055763 4173 5497911
SGTC_502 l-744,832 89.3 µM -1.09412848959201 0.151827661505952 no 2880 0.136949314499152 4206 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3340 9146634 11.102 µM -1.0947451374695 0.151692819927846 no 2881 0.136814153904625 4202 4907387
SGTC_1355 1499-0035 1.68 µM -1.09579124729541 0.151464250564853 no 2882 0.1365850698689 4184 1548538
SGTC_442 cape 100 µM -1.09662527545611 0.151282184052295 no 2883 0.136402616912962 4188 5281787
SGTC_1795 st049545 62.3 µM -1.09698453991634 0.151203802286646 no 2884 0.136324075209309 4148 5291882
SGTC_477 mead ethanolamide 10 µM -1.09817053871309 0.150945241331186 no 2885 0.136065014141644 4103 16061185
SGTC_1430 4049-0248 69.1 µM -1.09976892991119 0.150597240053705 no 2886 0.135716406465898 4203 22774488
SGTC_1322 1348-1070 12 µM -1.10151192083451 0.15021836607961 no 2887 0.135336959568752 4184 6758089
SGTC_2255 7941087 197.44 µM -1.10209306810586 0.150092183428128 no 2888 0.1352106063504 4294 935561
SGTC_1859 st055998 20 µM -1.10251008704783 0.15000168099395 no 2889 0.135119987819312 4153 676301
SGTC_25 0118-0223 35.662 µM -1.10375831057784 0.149731006075043 no 2890 0.134848996823632 4194 5333628
SGTC_2097 5376186 200 µM -1.10388270907274 0.149704048362017 no 2891 0.134822010190092 4169 742755
SGTC_2352 9027995 87.8 µM -1.10466263261522 0.149535109217656 no 2892 0.134652900374721 4167 2997347
SGTC_2379 9035213 200 µM -1.10561575356777 0.1493288266175 no 2893 0.134446434122735 4201 646551
SGTC_532 1548-0774 215 µM -1.10571181572503 0.149308046566675 no 2894 0.134425637081715 4317 5932993
SGTC_615 k087-0205 167 µM -1.10635407683383 0.149169163019817 no 2895 0.134286647085059 4209 9642773
SGTC_3041 9091929 49.47 µM -1.10787437129857 0.148840756085993 no 2896 0.133958037669797 4204 25236887
SGTC_1258 0671-0043 57.1 µM -1.10856402205611 0.148691940359057 no 2897 0.133809153011865 4223 4298767
SGTC_1283 0922-0125 16.4 µM -1.10959182434191 0.148470341504791 no 2898 0.133587477943073 4197 3360884
SGTC_831 k061-1017 217 µM -1.10959833560957 0.148468938350185 no 2899 0.133586074406735 4231 1240153
SGTC_632 0781-2353 4.65 µM -1.11107318071358 0.148151343052866 no 2900 0.133268425410097 4274 6811515 YHR007C ERG11
SGTC_80 0159-0065 512.242 µM -1.11276922717803 0.147786676311646 no 2901 0.13290377747537 4098 1548079
SGTC_851 0394-0702 453 µM -1.1131387571597 0.147707303526281 no 2902 0.13282442020617 4194 762646
SGTC_1855 st056195 39.6 µM -1.11358415353878 0.147611673050924 no 2903 0.132728813857279 4151 4028379
SGTC_3254 9136651 49.47 µM -1.1161112355476 0.147069871869359 no 2904 0.132187261689978 4159 16454030
SGTC_1409 3909-8004 61.9 µM -1.12230681998643 0.145747199513063 no 2905 0.130866003709917 4245 2119279
SGTC_1842 st055362 61.2 µM -1.12355714392739 0.145481245198742 no 2906 0.130600472784123 4174 676032
SGTC_2889 9059656 51.95 µM -1.12419836516437 0.145344978794815 no 2907 0.130464441429401 4289 3949838
SGTC_642 0335-0876 158 µM -1.12551985173257 0.145064419590958 no 2908 0.130184404902155 4263 6812350
SGTC_2676 harmalol 100 µM -1.12626796313698 0.144905752927544 no 2909 0.13002605695152 4180 5459187 A monoamine oxidase inhibitor
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.12643472650076 0.144870400081023 no 2910 0.129990777396605 4274 1273210
SGTC_898 1000-0849 28.3 µM -1.12920820711813 0.144283290044641 no 2911 0.129405006193802 4215 6751807
SGTC_449 xestospongin c 11.1929 µM -1.13149426912456 0.143800567673838 no 2912 0.128923557083894 4235 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1094 duloxetine 25.4 µM -1.13181754372531 0.143732393400322 no 2913 0.128855575214579 4228 60834 A selective serotonin reuptake inhibitor.
SGTC_158 k038-0087 26.446 µM -1.13276594017784 0.143532515179347 no 2914 0.128656279087059 4137 X158
SGTC_3225 9130819 49.47 µM -1.13465609763934 0.143134717020314 no 2915 0.128259719390069 4171 4547121
SGTC_2221 6807166 181.081 µM -1.13542321475685 0.142973483998106 no 2916 0.12809901871901 4194 674925
SGTC_2943 9068529 45.32 µM -1.1367870392189 0.142687137912204 no 2917 0.127813661385658 4213 3270634
SGTC_1425 4048-4433 7.33 µM -1.13919029959169 0.142183497960156 no 2918 0.127311895315675 4281 23734946
SGTC_2162 5663267 200 µM -1.14004130148315 0.142005446275333 no 2919 0.127134547344657 4230 6456493
SGTC_2768 sulfasalazine 50.2 µM -1.14153841669552 0.141692577400066 no 2920 0.126822967357062 4211 5384001 An antioxidant and salicylic acid derivative.
SGTC_1119 parthenolide 318.541 nM -1.1433892581229 0.141306432292707 no 2921 0.12643850520853 4319 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_716 1683-5115 658 µM -1.14559499280936 0.140847177445174 no 2922 0.125981385024757 4210 723597
SGTC_3304 9125678 46.087 µM -1.15125029508905 0.139674320602363 no 2923 0.124814639618271 4171 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3107 9121808 49.47 µM -1.15294232759864 0.139324703211233 no 2924 0.124467028525889 4183 662681
SGTC_3227 9130768 49.47 µM -1.15328480827777 0.13925401042099 no 2925 0.12439675175872 4297 17720899
SGTC_1428 4049-0204 61.7 µM -1.15354502756873 0.139200313849614 no 2926 0.124343373518117 4284 X1428
SGTC_133 0724-0033 378.92 µM -1.15440124548604 0.139023731695512 no 2927 0.124167852394694 4066 280309
SGTC_2931 9014674 55.67 µM -1.15505094226261 0.138889843239246 no 2928 0.124034782960555 4208 2996810
SGTC_2341 7987486 176.74 µM -1.15534991577204 0.138828260771847 no 2929 0.123973581416143 4276 1258686
SGTC_204 PMA1.184 62.41 µM -1.15723369720137 0.138440667799311 no 2930 0.123588446933062 4228 2252213 YGL008C PMA1
SGTC_5 0352-0601 109.883 µM -1.15739783570099 0.138406930834254 no 2931 0.123554928948183 4156 762456
SGTC_3060 1327-0027 12.5 µM -1.15752309794592 0.138381188249882 no 2932 0.123529353991963 4159 16000455 YPR107C YTH1
SGTC_176 1486-1328 72.834 µM -1.1582345097688 0.138235048242802 no 2933 0.123384174436436 4313 22310231
SGTC_2878 9043973 25.97 µM -1.15939165352929 0.13799756968649 no 2934 0.123148288686092 4288 6465167
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.16027546503086 0.13781637415995 no 2935 0.122968335211715 4278 6708760
SGTC_990 3985-0011 41.3 µM -1.16091376854418 0.137685612703001 no 2936 0.122838484497701 4222 5399565 YGL099W LSG1
SGTC_2084 5306078 60.6385 µM -1.16151650938916 0.137562214285904 no 2937 0.122715956629358 4174 679340
SGTC_1145 3546-0597 10.2 µM -1.1615752871645 0.137550184822943 no 2938 0.122704012608064 4214 875334
SGTC_1642 st009582 77.7 µM -1.16162519580639 0.137539971081104 no 2939 0.122693871491792 4235 6739311
SGTC_2371 9071574 200 µM -1.16255127186853 0.13735054468903 no 2940 0.122505805425129 4252 45596039
SGTC_512 prima-1 270 µM -1.16280634758846 0.137298400937803 no 2941 0.122454040598168 4267 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2066 5222451 176 µM -1.1658518911635 0.136676861252088 no 2942 0.121837166385836 4212 2281147
SGTC_41 0478-0632 82.643 µM -1.16604186985015 0.136638153927653 no 2943 0.121798758711443 4220 3750424
SGTC_257 daunorubicin 18.5 µM -1.16625298369914 0.136595149200246 no 2944 0.121756088156029 4271 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1834 st055981 52.8 µM -1.16778450728582 0.136283448913912 no 2945 0.121446849461411 4261 471719 YDL150W RPC53
SGTC_577 r071-0003 38.6 µM -1.16801732797307 0.136236107197302 no 2946 0.121399887696147 4239 4568517 YMR134W ERG29
SGTC_1798 st045719 60.953 µM -1.16821582241814 0.13619575426065 no 2947 0.121359859888011 4195 3980186
SGTC_3193 9111931 49.47 µM -1.16824245763809 0.13619034007498 no 2948 0.121354489413847 4265 17087244
SGTC_1999 st074831 12.5 µM -1.17409449699976 0.135004356385746 no 2949 0.120178588716024 4230 17112523
SGTC_1974 st069448 26.9 µM -1.17537968345359 0.134744849934149 no 2950 0.119921423957194 4264 6323587 YNR016C ACC1
SGTC_23 0213-0011 39.996 µM -1.17547995418813 0.13472461754658 no 2951 0.119901376191504 4266 627608
SGTC_3286 9117135 37.221 µM -1.17681790714817 0.134454848105149 no 2952 0.119634096825776 4240 3438150
SGTC_1992 st073643 23.3 µM -1.17844327746718 0.134127626360733 no 2953 0.119309966536997 4241 3161292
SGTC_3239 9133757 49.47 µM -1.1787371352627 0.134068524957275 no 2954 0.119251431822259 4300 17036923
SGTC_1153 4055-0057 267 µM -1.17952428107379 0.133910300416269 no 2955 0.119094736958822 4324 882706
SGTC_1211 1056-0033 32.3 µM -1.1799232092519 0.133830160699478 no 2956 0.119015378994784 4326 6741922
SGTC_3145 9085516 49.47 µM -1.1812957996936 0.133554676196543 no 2957 0.118742617664846 4268 25236195
SGTC_2431 5490079 200 µM -1.18154317623495 0.133505068220122 no 2958 0.11869350597449 4320 5722345
SGTC_2749 bexarotene 57.39 µM -1.18160019183494 0.133493636319909 no 2959 0.118682188696778 4292 82146 An retinoic acid receptor inhibitor.
SGTC_2635 hydroquinidine 100 µM -1.18242227278434 0.13332887999717 no 2960 0.118519094966141 4181 442912 An experimental heart treatment.
SGTC_99 0109-0120 622.8 µM -1.18578089667618 0.132657219206045 no 2961 0.117854418777711 4237 759414
SGTC_3315 9136395 68.55 µM -1.18658130103495 0.132497498086842 no 2962 0.117696407607755 4265 16876844
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.19002819309072 0.131811183222565 no 2963 0.117017655595798 4300 61125 An anti-inflammatory.
SGTC_1826 st055655 41.6 µM -1.1935091812016 0.131120572566846 no 2964 0.116335009305023 4304 676168
SGTC_621 3584-0052 32.1 µM -1.19413576458604 0.130996527487148 no 2965 0.116212432564571 4302 2273927
SGTC_343 4130-2827 29.8 µM -1.19477827575539 0.130869413399128 no 2966 0.116086835122464 4273 1118244
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.19518274163188 0.130789437807869 no 2967 0.116007819970203 4283 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2280 7785178 200 µM -1.19812683563589 0.13020831595241 no 2968 0.115433821522896 4271 2954328
SGTC_328 k915-0120 63.5 µM -1.19855865481638 0.130123231524437 no 2969 0.115349801449474 4275 6624543
SGTC_2004 4023728 41.89 µM -1.19967742998348 0.129902970240231 no 2970 0.11513232094435 4270 360084 YDR527W RBA50
SGTC_1983 st071813 46.9 µM -1.20213854223403 0.129419342293478 no 2971 0.114654927852253 4346 11838595
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.20353438184846 0.129145603965873 no 2972 0.114384797369098 4128 88881 An O-methylated flavonoid and antioxidant.
SGTC_534 k292-0788 63.4 µM -1.20462827675361 0.128931360799687 no 2973 0.114173417788168 4340 4146317
SGTC_444 curcumin 90.4 µM -1.21008279738039 0.127866753316548 no 2974 0.113123561721502 4223 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2742 clothiapine 36.27 µM -1.2138561413728 0.127133860185614 no 2975 0.112401331730304 4330 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1656 st012921 11 µM -1.21502458435264 0.126907508439164 no 2976 0.112178357512092 4197 6732821
SGTC_2821 7996764 71.43 µM -1.21941756517449 0.126059007293675 no 2977 0.111342873209352 4338 2987135
SGTC_1272 0839-0021 27 µM -1.21998010267458 0.125950639910142 no 2978 0.111236208895507 4305 5027250
SGTC_1896 st058441 89 µM -1.22209814344407 0.12554320276565 no 2979 0.110835257559414 4306 688759
SGTC_2119 5528445 120.635 µM -1.22214076898662 0.125535012550756 no 2980 0.110827199061724 4320 791935
SGTC_2016 5121758 140 µM -1.22219649697295 0.125524305350734 no 2981 0.110816664137532 4243 2795203
SGTC_2103 5378138 10 µM -1.22360089858733 0.125254683470577 no 2982 0.110551410235328 4376 244142
SGTC_739 1486-1183 203 µM -1.22542120731148 0.124905816382622 no 2983 0.110208280274245 4311 4346692
SGTC_2419 paclitaxel 166.5 µM -1.22655534263022 0.124688799835191 no 2984 0.109994881269631 4233 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1086 cerivastatin 2.18 µM -1.22959636713096 0.124108201573738 no 2985 0.109424145555911 4303 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1739 st037196 92.5 µM -1.23074885397846 0.12388866159304 no 2986 0.109208405005117 4357 612214
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.23276550777523 0.123505158637842 no 2987 0.108831631750945 4333 5282362
SGTC_478 N-arachidonylglycine 10 µM -1.23391180750666 0.123287540166921 no 2988 0.108617884599331 4302 5283389
SGTC_987 1497-1013 404 µM -1.23513763293361 0.123055121635339 no 2989 0.108389642804384 4324 1676435
SGTC_563 tetrahydrosecaminediol 614 µM -1.23557526530457 0.122972220258835 no 2990 0.108308241775317 4366 334274 A psychoactive constituent of the cannabis plant.
SGTC_1305 1181-0477 144 µM -1.23916846649701 0.122293035022068 no 2991 0.107641557911375 4375 6252086
SGTC_1198 1612-1005 86.7 µM -1.23930516558355 0.122267248319327 no 2992 0.107616253225637 4391 6998509
SGTC_2220 6782180 200 µM -1.24010489716447 0.122116464684318 no 2993 0.107468298939854 4239 833803
SGTC_1988 st071872 53.4 µM -1.24027409293691 0.122084580780208 no 2994 0.107437015685901 4347 16414116
SGTC_2441 5730946 39.09 µM -1.24037190007493 0.122066152292343 no 2995 0.107418934743827 4370 1774275
SGTC_1556 plumbagin 1.48 µM -1.24290266241833 0.121589993748609 no 2996 0.10695185224453 4251 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_675 1309-0189 238 µM -1.24362845132232 0.121453679026061 no 2997 0.106818169948059 4330 4246530
SGTC_264 promethazine 12.5 mM -1.24531048532355 0.121138179342239 no 2998 0.106508821452795 4198 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2658 polymyxin b sulfate 77.05 µM -1.24546781871876 0.121108697775385 no 2999 0.106479918854786 4339 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1877 wortmannin 25 µM -1.2499772150647 0.120265859263575 no 3000 0.105653935373713 4333 312145 A covalent inhibitor of PI 3-kinase.
SGTC_70 0141-0289 43.283 µM -1.25316976012645 0.119671653644322 no 3001 0.105071966297532 4288 352408
SGTC_427 1354-0053 47.3 µM -1.2534178264378 0.119625569677998 no 3002 0.105026843622295 4379 6813657
SGTC_1710 st031758 61.5 µM -1.25692888023441 0.11897465350285 no 3003 0.104389694845233 4369 5394341
SGTC_2275 7947463 200 µM -1.25859473495557 0.11866669618807 no 3004 0.104088374861641 4295 1225414
SGTC_2384 9036245 200 µM -1.25891593475708 0.118607382587364 no 3005 0.104030348794857 4259 6462766
SGTC_1833 st055984 71 µM -1.25964968521436 0.118471964893639 no 3006 0.103897881752636 4341 676288
SGTC_1130 3454-2858 15.9 µM -1.25993582026577 0.11841918671871 no 3007 0.103846257762686 4325 715628 YIL048W NEO1
SGTC_2413 inermin 26.06 µM -1.26273464323759 0.117903814521246 no 3008 0.103342279762431 4395 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_519 k048-0011 62.8 µM -1.26339547474532 0.117782361653022 no 3009 0.103223544811216 4361 6836379
SGTC_2246 7293507 91.5585 µM -1.26453487871377 0.117573160909482 no 3010 0.103019055013546 4401 887656
SGTC_1276 0871-0068 94.2 µM -1.26848039918907 0.116850774925013 no 3011 0.102313223036503 4359 3414906
SGTC_1387 3342-1166 1.8 µM -1.27091120944256 0.116407286789991 no 3012 0.101880119064983 4310 3418228
SGTC_2888 9058547 12.99 µM -1.2711203147247 0.116369192517229 no 3013 0.101842924643063 4249 16476514
SGTC_2254 7938975 95.19 µM -1.27185427024791 0.116235552355669 no 3014 0.101712451168657 4404 2969277
SGTC_631 k072-0230 41.5 µM -1.27331110191844 0.115970612095118 no 3015 0.101453834365124 4335 5773147
SGTC_1775 st081588 35.1725 µM -1.27467570008104 0.115722834609809 no 3016 0.101212025596821 4332 1426443 YGL099W LSG1
SGTC_3081 9117243 49.47 µM -1.277705959365 0.115173959144925 no 3017 0.100676561598557 4321 45595589
SGTC_3185 9108267 49.47 µM -1.27789942747324 0.115138978935824 no 3018 0.10064244499104 4353 4910486
SGTC_3237 9133362 49.47 µM -1.27923635136492 0.114897461420148 no 3019 0.100406919243013 4326 43845137
SGTC_2606 farnesol 9.78 µM -1.27958554274835 0.114834438813533 no 3020 0.100345468530387 4359 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2621 lithochol-11-enic acid 100 µM -1.28109882970682 0.114561602638193 no 3021 0.100079477435968 4320 6708711
SGTC_2171 5739187 198.077 µM -1.28110158948206 0.114561105489804 no 3022 0.100078992819829 4288 2262761
SGTC_3076 9116187 49.47 µM -1.28439090615949 0.113969656179214 no 3023 0.0995026066239511 4334 27241210
SGTC_2919 7978188 46.38 µM -1.28643831079231 0.113602614361629 no 3024 0.099145067619284 4372 2980291
SGTC_1467 k284-1082 293 µM -1.28959524125044 0.113038318767987 no 3025 0.0985956144240145 4328 3334705
SGTC_83 0170-0301 39.027 µM -1.29112609030802 0.112765403648492 no 3026 0.0983299792056973 4363 3089716
SGTC_1179 1021-1431 9.29 µM -1.29409600365941 0.112237278950868 no 3027 0.0978161308928537 4375 2840958
SGTC_2877 9040724 71.43 µM -1.29455763092763 0.112155349099232 no 3028 0.0977364381676382 4323 6463895
SGTC_2047 4141938 200 µM -1.3004717397839 0.111109490244293 no 3029 0.0967196679894238 4381 3807862
SGTC_2614 arthonioic acid 13.39 µM -1.3009808620571 0.111019783964798 no 3030 0.0966325027841305 4215 6710684
SGTC_1429 4049-0205 9.46 µM -1.30493385168879 0.1103250400575 no 3031 0.0959576865388898 4409 22774478
SGTC_3100 9120536 49.47 µM -1.30548611638892 0.110228227456216 no 3032 0.0958636858242223 4241 16421196
SGTC_1643 st009866 20.2 µM -1.31106989730575 0.109252805703614 no 3033 0.0949170749271513 4342 3156273 YOR207C RET1
SGTC_1881 5652484 16 µM -1.31227378766633 0.109043315192142 no 3034 0.0947138865412228 4364 2255129
SGTC_932 2857-0803 154 µM -1.31245383698555 0.109012009412931 no 3035 0.094683526027033 4396 674898
SGTC_500 h-89 112 µM -1.31476349267836 0.108610994670424 no 3036 0.0942947001962474 4354 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_759 3486-0358 89.3 µM -1.317520459601 0.108133705929844 no 3037 0.0938321138373903 4368 875103
SGTC_3070 9117005 49.47 µM -1.32076718310727 0.107573568391039 no 3038 0.0932895025534588 4480 8779016
SGTC_1692 fluoroquinolonic acid 71 µM -1.32220768636815 0.107325717843022 no 3039 0.0930495011359831 4390 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3029 9088683 49.47 µM -1.32660999222153 0.106570816693935 no 3040 0.0923188643750899 4407 25236615
SGTC_85 0868-0259 160.055 µM -1.3281749769565 0.106303380994637 no 3041 0.0920601544407667 4310 83173
SGTC_2634 4'-methoxyflavone 100 µM -1.33023928198074 0.105951359689511 no 3042 0.0917197226770808 4394 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_220 paclitaxel 373.376 µM -1.33291104203452 0.105497002201868 no 3043 0.0912804992535273 4355 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2077 5212015 200 µM -1.33435795768865 0.105251529847587 no 3044 0.0910432857771612 4299 780900
SGTC_2207 7258803 200 µM -1.33496625465445 0.105148454444157 no 3045 0.0909436956332143 4409 3666799
SGTC_452 diindolylmethane 8 µM -1.33514474395802 0.105118223450318 no 3046 0.0909144887750551 4385 3071 Inhibits expression of several cancer promoting factors.
SGTC_468 gf-109203x 121 µM -1.34279468954565 0.103828447386023 no 3047 0.0896692317132563 4441 2396 A protein kinase C inhibitor.
SGTC_1712 st032288 53.4 µM -1.34683324307352 0.10315219743588 no 3048 0.08901697280383 4211 2883011
SGTC_1882 5615643 20 µM -1.34914646876267 0.102766294852789 no 3049 0.0886449624990832 4345 2253075
SGTC_1605 st000082 49.1 µM -1.35347808997464 0.102046498277985 no 3050 0.0879514724858152 4365 1114022
SGTC_1539 benzyladenosine 56 µM -1.35861180012964 0.101198175253028 no 3051 0.0871348169825385 4410 92208 A nucleotide analog.
SGTC_2799 7812892 81.82 µM -1.35916881907716 0.101106440281981 no 3052 0.0870465497190096 4429 20205235
SGTC_2880 9042983 58.44 µM -1.36359585967202 0.100379509027878 no 3053 0.0863473979587444 4363 6464714
SGTC_1934 st074720 32.6 µM -1.36530606180336 0.100099713218958 no 3054 0.0860784372761252 4350 17250992
SGTC_601 0986-0029 62.9 µM -1.38004268349315 0.0977123062387415 no 3055 0.0837867515578968 4387 24747981
SGTC_2080 5212524 12.4 µM -1.3807829381763 0.0975934920115051 no 3056 0.083672855527668 4377 260183
SGTC_797 k781-0471 270 µM -1.38094242437571 0.0975679076319706 no 3057 0.0836483321221228 4398 23738129
SGTC_3103 9120822 49.47 µM -1.38398220414537 0.09708121361663 no 3058 0.0831819519413732 4436 17141819
SGTC_211 3455-0679 143.504 µM -1.38531927539727 0.0968677025663084 no 3059 0.0829774311647299 4420 748649
SGTC_3218 9131285 49.47 µM -1.38604427914389 0.096752074154895 no 3060 0.0828666915850746 4409 17156417
SGTC_691 1548-0686 185 µM -1.38631476698766 0.0967089609305446 no 3061 0.0828254048281931 4403 46495133
SGTC_1142 3253-1408 9.78 µM -1.38837712924422 0.09638070357841 no 3062 0.0825111184596297 4442 256655
SGTC_2568 diosmetin 100 µM -1.39340232587277 0.0955842941375343 no 3063 0.0817490813953789 4440 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1471 k673-0312 37 µM -1.39380055671929 0.0955213889309641 no 3064 0.0816889200021584 4400 24099884
SGTC_2011 4012611 177 µM -1.39469116699642 0.0953808169245636 no 3065 0.0815544948346631 4398 2049887
SGTC_733 4069-0007 56.1 µM -1.39674909460128 0.0950565806748046 no 3066 0.081244517546538 4439 5717425 YNL287W SEC21
SGTC_1433 4060-0023 7.6 µM -1.39690511016763 0.0950320328298385 no 3067 0.0812210538528433 4450 3840627
SGTC_3049 9092223 49.47 µM -1.39951450621069 0.0946221564254017 no 3068 0.0808293756951435 4423 8623917
SGTC_206 4546-0025 72.014 µM -1.40267688487483 0.0941271675000957 no 3069 0.0803566066184667 4479 6620745 YIL048W NEO1
SGTC_3019 9081971 49.47 µM -1.4043883304741 0.0938600827529569 no 3070 0.0801016219634812 4449 16451803
SGTC_3086 9117350 49.47 µM -1.40472675170197 0.0938073357247229 no 3071 0.0800512738130526 4406 2679265
SGTC_2836 9010338 19.48 µM -1.40772367648498 0.0933411834310729 no 3072 0.0796064540711209 4407 2994051
SGTC_1825 st052143 62.6 µM -1.41069128875361 0.0928812789857826 no 3073 0.0791678303481235 4478 674173
SGTC_869 0564-0080 44.1 µM -1.4124198280662 0.092614172641336 no 3074 0.0789131907904318 4440 6843321
SGTC_1081 sertraline 6 µM -1.41278477721043 0.0925578507889084 no 3075 0.0788595077649456 4425 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_667 1498-1044 59 µM -1.41295254179516 0.0925319685275986 no 3076 0.0788348393356771 4443 6739982
SGTC_2315 7733312 200 µM -1.4153994756149 0.0921550706561819 no 3077 0.0784757016494488 4345 726316
SGTC_1186 1319-0216 26 µM -1.418896985401 0.0916183288506782 no 3078 0.077964525660663 4490 4565136
SGTC_560 2332-1943 155 µM -1.42683359952341 0.0904089428087564 no 3079 0.0768139319412529 4447 21177716
SGTC_3187 9109394 49.47 µM -1.42713395980893 0.0903634076475767 no 3080 0.0767706427567698 4450 17098090
SGTC_323 4013-0906 34.3 µM -1.43019199179093 0.0899007735039971 no 3081 0.076330961623033 4461 2910086
SGTC_2794 7785382 27.27 µM -1.4308572885049 0.0898003576923489 no 3082 0.0762355601288502 4456 2205081
SGTC_2354 9060492 162 µM -1.43165982794088 0.0896793382782038 no 3083 0.0761205992415714 4476 6471895
SGTC_1830 st055982 50.3 µM -1.43909410046817 0.0885640417945953 no 3084 0.075061931653979 4460 455313 An antimicrobial agent.
SGTC_1331 1472-0049 76.2 µM -1.43937793524095 0.0885216663405649 no 3085 0.0750217362123967 4426 24051409
SGTC_3150 9097574 49.47 µM -1.44335458138067 0.0879295555517215 no 3086 0.0744603057656564 4500 17217476
SGTC_2027 5150920 200 µM -1.44636723282261 0.0874829508066314 no 3087 0.0740371136689107 4412 786715
SGTC_1462 k081-0014 26.5 µM -1.44905808827014 0.0870854833819352 no 3088 0.0736606806013859 3906 3270634
SGTC_1023 4482-3888 16 µM -1.45187196728916 0.0866712883033268 no 3089 0.073268604217843 4475 3303168
SGTC_2300 7976697 71.57 µM -1.45314643341517 0.0864841756439675 no 3090 0.0730915505847406 4355 2236109
SGTC_2822 7994718 71.43 µM -1.45439869789257 0.0863006168745285 no 3091 0.0729179003768269 4471 1018011
SGTC_2570 licareol 100 µM -1.45470727358438 0.0862554301717905 no 3092 0.0728751590435426 4428 443158
SGTC_1811 st050069 61.5 µM -1.45800157709552 0.0857741267077802 no 3093 0.0724200541559029 4463 3877702
SGTC_2911 7942208 15.64 µM -1.46735788170619 0.0844181195947715 no 3094 0.0711393628262181 4491 1243384
SGTC_774 k060-0086 136 µM -1.47214348881174 0.0837307905824266 no 3095 0.0704910669390555 4477 5911235
SGTC_772 k072-0172 35.3 µM -1.47299881122232 0.0836083896601558 no 3096 0.0703756781624678 4520 5861980
SGTC_1545 lovastatin 49.4 µM -1.48878302775029 0.0813736570864209 no 3097 0.0682722565028995 4514 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_101 0490-5701 117.494 µM -1.49293010999496 0.080794054184579 no 3098 0.0677277412357371 4361 4661669
SGTC_886 0866-0150 153 µM -1.49420466500182 0.0806165480211623 no 3099 0.0675610668435099 4524 271463
SGTC_1418 3966-3099 2.4 µM -1.49622447307061 0.080335854586221 no 3100 0.0672975845565542 4500 740335
SGTC_3132 9126706 49.47 µM -1.49919022861525 0.0799250416947966 no 3101 0.0669121446223757 4511 850858
SGTC_1794 st048918 76.9 µM -1.50034520564588 0.0797654861622904 no 3102 0.0667625026381447 4467 672303
SGTC_823 0417-1665 178 µM -1.50650454980884 0.0789186629953178 no 3103 0.0659688500165032 4528 3429856
SGTC_490 phenamil 164 µM -1.50739529386216 0.0787967639796429 no 3104 0.0658546821813642 4512 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1321 1326-2144 215 µM -1.50972234614596 0.0784789782918468 no 3105 0.0655571434132999 4466 3513030
SGTC_626 0214-0009 33 µM -1.51127596931678 0.0782673547172673 no 3106 0.0653590769287985 4555 3437874
SGTC_1824 st053723 68.6 µM -1.5116039698035 0.0782227321868426 no 3107 0.0653173205938932 4522 675225
SGTC_2753 fluvastatin 17.09 µM -1.51318171600425 0.0780083587213229 no 3108 0.0651167536256605 4491 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1571 st070080 73.4 µM -1.51795946934037 0.0773619085170356 no 3109 0.0645123082571497 4502 4315245
SGTC_2916 7875993 68.79 µM -1.51886491231675 0.0772398582150821 no 3110 0.0643982512916026 4404 1299250
SGTC_998 3996-0085 177 µM -1.52271804956485 0.0767221052504482 no 3111 0.0639146301283141 4537 715391
SGTC_825 1988-2224 89.6 µM -1.52287688556453 0.0767008189482005 no 3112 0.0638947548308742 4490 1180859
SGTC_1553 gossypol 38.6 µM -1.52334300759757 0.0766383778379468 no 3113 0.0638364562939517 4427 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2545 solidagenone 89.61 µM -1.52903336604139 0.0758792183746645 no 3114 0.0631280862699626 4442 6708572 An anti ulcer agent
SGTC_1209 2323-2347 50.3 µM -1.53326670197932 0.0753181675516394 no 3115 0.0626050776966991 4526 5412760
SGTC_2168 5727979 200 µM -1.53607230218747 0.0749480828300141 no 3116 0.0622603242742449 4425 695210
SGTC_465 cgp-37157 41 µM -1.53630956033426 0.074916849998326 no 3117 0.0622312379252722 4562 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2271 7849410 118.62 µM -1.54331194598559 0.0739995150509597 no 3118 0.061377553271781 4445 972430
SGTC_34 0469-0683 81.75 µM -1.54372106087805 0.0739461862210226 no 3119 0.0613279609556263 4497 3690923
SGTC_513 4245-1575 41.7 µM -1.54467402891395 0.0738220790735764 no 3120 0.0612125649369881 4346 719745
SGTC_1008 4106-0037 6 µM -1.54691674962847 0.0735306327962464 no 3121 0.0609416607844205 4544 2905394
SGTC_810 3825-7150 143 µM -1.54918992059371 0.0732361281057051 no 3122 0.060668035870845 4540 22330411 YGL099W LSG1
SGTC_1206 3978-0017 132 µM -1.55129981152477 0.0729635857589666 no 3123 0.0604149259944752 4551 3873677
SGTC_2455 5377712 9.75 µM -1.55217780084046 0.0728504016683017 no 3124 0.0603098431246445 4518 2243908
SGTC_697 0508-1955 564 µM -1.55234412051093 0.0728289760794202 no 3125 0.0602899531446786 4532 6243113
SGTC_3285 9112818 20.8695 µM -1.55430725348854 0.0725764462796486 no 3126 0.0600555720775672 4502 17017947 YPR165W RHO1
SGTC_1317 1273-0028 910 nM -1.56296715888838 0.0714704680690867 no 3127 0.0590301597919588 4545 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2037 5169046 200 µM -1.56691790218468 0.0709702252371651 no 3128 0.0585669412925627 4581 5718022
SGTC_982 1491-0518 27.5 µM -1.56776021343616 0.0708639204901571 no 3129 0.0584685516783314 4480 3091256
SGTC_989 1501-0895 10.3 µM -1.56904019683157 0.0707026131260807 no 3130 0.0583192865142171 4507 2830112
SGTC_2670 beta-carotene 100 µM -1.57391364022661 0.0700910285299193 no 3131 0.0577537080164518 4508 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_676 falcarinol 140 µM -1.57635591388781 0.0697860742484765 no 3132 0.0574719012066074 4550 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_798 1287-0182 476 µM -1.57833571858107 0.06953961641527 no 3133 0.0572442521365339 4572 1649755
SGTC_1243 0416-0003 5.65 µM -1.57896976096697 0.0694608289111642 no 3134 0.0571714965959539 4517 2141977
SGTC_1929 genistein trimethyl ether 50.5 µM -1.57974069552723 0.0693651235160005 no 3135 0.057083130927454 4485 136420
SGTC_1814 st052110 31.539 µM -1.58216374952004 0.0690649818670028 no 3136 0.0568060967528299 4481 674163
SGTC_2626 ethyl orsellinate 100 µM -1.58263541766643 0.0690066732806654 no 3137 0.0567522930162302 4484 75653 A natural product.
SGTC_1975 st070967 30.8 µM -1.58358882882671 0.0688889264997307 no 3138 0.0566436588705604 4534 261391
SGTC_931 2812-0076 566 µM -1.58682164366903 0.0684908249189499 no 3139 0.0562765227022718 4464 3450959
SGTC_658 3253-0951 102 µM -1.58891601465336 0.0682338646592785 no 3140 0.0560396775464462 4553 1184878
SGTC_2761 levamisole 97.89 µM -1.59175143651916 0.0678871705029302 no 3141 0.0557202829521619 4541 26879 An alkaline phosphatase inhibitor.
SGTC_1690 st023502 41.2 µM -1.59873843423964 0.0670386595820871 no 3142 0.0549393669132781 4557 24207482
SGTC_3072 9116419 49.47 µM -1.59949756522854 0.0669469658364261 no 3143 0.0548550445881841 4553 17170162
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.60298257013372 0.0665272643252163 no 3144 0.054469251142367 4550 23847180
SGTC_52 0329-0193 875 nM -1.60841374640177 0.0658772483400057 no 3145 0.05387229650137 4578 3739292
SGTC_2824 7998404 51.95 µM -1.60877651474477 0.0658340073494452 no 3146 0.053832608981177 4528 837851
SGTC_1059 3448-6867 171 µM -1.61170019625756 0.0654863151912647 no 3147 0.0535135974830141 4515 3934407
SGTC_1875 nocodazole 6 µM -1.61324290549513 0.0653034268697701 no 3148 0.0533458726447431 4572 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_466 geldanamycin 89.2 µM -1.61924162549709 0.0645960419209499 no 3149 0.0526976425316111 4582 5288382 HSP90 inhibitor.
SGTC_113 0099-0221 2.5 µM -1.62227305928106 0.0642408383763327 no 3150 0.0523724472426841 4520 89219
SGTC_571 k831-0106 44.2 µM -1.62319567074319 0.064133034676267 no 3151 0.0522737915131895 4455 4783639
SGTC_3234 9132280 49.47 µM -1.62648368432511 0.0637499859609812 no 3152 0.0519234007129573 4574 17612295
SGTC_183 3914-0051 30.55 µM -1.62746402801953 0.0636361224708092 no 3153 0.0518192912590436 4549 1596232
SGTC_2112 5488546 200 µM -1.62751529466841 0.0636301723855357 no 3154 0.0518138514683233 4520 600757
SGTC_1622 st003707 19.4 µM -1.62797997008487 0.0635762611909572 no 3155 0.051764566484987 4565 10140899
SGTC_1829 berberine 14.4 µM -1.62864358203559 0.0634993312051402 no 3156 0.0516942462606118 4523 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_260 nsc-65238 3.989 µM -1.63532407569053 0.0627289173288787 no 3157 0.0509905645661971 4541 3246252
SGTC_2041 5107442 45.335 µM -1.63592308117051 0.0626601956905642 no 3158 0.0509278433357904 4580 793005
SGTC_1208 2323-2347 50.3 µM -1.63797641931677 0.0624250692178683 no 3159 0.050713306461595 4580 5412760
SGTC_1098 clofazimine 15.1 µM -1.64101388784681 0.0620785128500659 no 3160 0.0503972661848596 4606 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3102 9121669 49.47 µM -1.65010172894617 0.0610506064531499 no 3161 0.0494610656037224 4599 41905072
SGTC_628 1636-0253 16 µM -1.65247952654861 0.0607838667483701 no 3162 0.0492184176928809 4562 4456143
SGTC_663 1486-0733 13.9 µM -1.65330800348758 0.060691143163624 no 3163 0.0491340974792028 4581 722445 YPR165W RHO1
SGTC_1141 3253-0389 52.6 µM -1.65478711637474 0.0605258751683887 no 3164 0.0489838441476971 4567 5402031
SGTC_2713 st079149 53.4 µM -1.65983201500545 0.0599648331795978 no 3165 0.0484741256233214 4590 3103253
SGTC_10 0279-0212 42.575 µM -1.66246830727722 0.0596732763785235 no 3166 0.0482094564049218 4590 39851 YBR002C RER2
SGTC_2355 9061122 103.12 µM -1.66363013878016 0.0595451385120164 no 3167 0.0480931825615376 4572 5302957
SGTC_385 1494-0393 12.4 µM -1.66634377237894 0.0592466931777781 no 3168 0.047822481516648 4532 3090647
SGTC_1346 1488-2224 62.4 µM -1.66748152560037 0.0591219126494851 no 3169 0.0477093474652305 4588 3722427
SGTC_3280 9140961 49.47 µM -1.66878744991472 0.0589789425170647 no 3170 0.0475797553925135 4598 4901226
SGTC_2765 myclobutanil 7.74 µM -1.67381969494093 0.058430556823288 no 3171 0.0470830202189391 4584 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_376 3970-0862 59.1 µM -1.67667060085632 0.0581216626776401 no 3172 0.0468034562841138 4597 3135186
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.67845831846971 0.0579286199321782 no 3173 0.0466288304735786 4540 6708630 An antioxidant.
SGTC_492 tmb-8 126 µM -1.6789443793599 0.0578762209524007 no 3174 0.0465814421301242 4608 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_127 0180-0333 59.125 µM -1.67896450725614 0.0578740519019273 no 3175 0.0465794806013014 4493 771601
SGTC_3098 9119039 49.47 µM -1.6808467068251 0.0576715019147129 no 3176 0.0463963468683903 4566 17161528
SGTC_2344 7990960 76.95 µM -1.6815410257184 0.0575969247667205 no 3177 0.0463289373351339 4570 140813
SGTC_1089 terbinafine 2.25 µM -1.68300542916915 0.057439881140452 no 3178 0.0461870202099016 4593 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2750 bromebric acid 70.15 µM -1.68326019020547 0.0574125948247366 no 3179 0.0461623666961126 4568 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_701 4424-0219 185 µM -1.68776759671968 0.056931511080333 no 3180 0.0457279250226091 4588 2911779
SGTC_1060 3448-7350 82 µM -1.6952344564427 0.056141550560042 no 3181 0.0450154764479773 4543 570178
SGTC_570 0987-0065 62.6 µM -1.69625233787277 0.0560345359427832 no 3182 0.0449190512622542 4489 3104428
SGTC_2031 5180455 200 µM -1.69722219051323 0.0559327205549289 no 3183 0.0448273306611652 4586 29949
SGTC_2342 7990637 118.86 µM -1.6980388289745 0.0558471028563775 no 3184 0.0447502167786953 4569 2033102 YER133W GLC7
SGTC_993 3909-8757 62.7 µM -1.69846003732261 0.0558029831288186 no 3185 0.0447104845163182 4552 4288324 YLR208W SEC13
SGTC_1779 st039427 55 µM -1.69881135666175 0.0557662050078505 no 3186 0.0446773665650782 4580 1124498
SGTC_1581 himbacine 57.9 µM -1.7007940525327 0.0555590034877949 no 3187 0.044490833240426 4597 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_882 0843-0131 351 µM -1.70478391181639 0.055143885742558 no 3188 0.0441173665531814 4605 5425421
SGTC_1398 3558-0053 112 µM -1.70723810169149 0.054889763526794 no 3189 0.043888902892228 4577 4532369
SGTC_1469 k284-2957 126 µM -1.7107729325807 0.0545253725880487 no 3190 0.043561519061712 4602 23884841
SGTC_2476 5806916 10.51 µM -1.71281843731659 0.054315385513047 no 3191 0.0433729735493863 4528 2870194
SGTC_3327 9140648 26.9345 µM -1.71858333565205 0.0537270150106876 no 3192 0.042845134086424 4599 8029710
SGTC_3223 9129970 49.47 µM -1.71884580371385 0.0537003479108138 no 3193 0.042821226376649 4601 17248386
SGTC_1703 st026983 48.3 µM -1.72800014675386 0.0527767966584135 no 3194 0.0419940990335033 4628 1104023
SGTC_1214 0358-0031 63.7 µM -1.72867148515164 0.0527095665957843 no 3195 0.0419339537825321 4610 4301366
SGTC_1167 k781-0610 148 µM -1.73097651998799 0.0524792498154315 no 3196 0.041727976180141 4626 4525169
SGTC_2015 5119600 184 µM -1.73452401347373 0.0521263494396372 no 3197 0.0414125743913226 4580 2828786
SGTC_407 eburnamonine 100 µM -1.73631657099297 0.0519487462612979 no 3198 0.0412539373868352 4470 3195
SGTC_3093 9117344 49.47 µM -1.73859333887161 0.0517238620012196 no 3199 0.0410531595190139 4620 24824913
SGTC_2709 st078560 56 µM -1.74057704675504 0.0515285557603399 no 3200 0.0408788719695532 4573 17250903
SGTC_636 0kpi-0074 126 µM -1.74106921912976 0.0514801897694444 no 3201 0.0408357230271498 4625 616434
SGTC_619 1652-1634 108 µM -1.74129738019817 0.0514577805340917 no 3202 0.0408157325973381 4594 5400454
SGTC_3153 9100258 49.47 µM -1.75110640705239 0.0505016844585418 no 3203 0.0399637914029568 4518 25236848
SGTC_609 0986-0026 86.3 µM -1.75643226158154 0.0499885271539385 no 3204 0.0395073141207423 4609 2848610
SGTC_2164 5685496 200 µM -1.77242318767134 0.0484727183402663 no 3205 0.0381621677595043 4567 759046
SGTC_2160 5660466 132.927 µM -1.77733493926415 0.048014575687483 no 3206 0.0377565741565687 4568 2859134
SGTC_3299 9121982 43.1275 µM -1.77752791035108 0.0479966473458586 no 3207 0.0377407114539845 4611 17594604 YPL160W CDC60
SGTC_1203 3992-3522 103 µM -1.78688470228031 0.0471337465527441 no 3208 0.0369780627474006 4618 5322312
SGTC_1240 0356-0016 42.1 µM -1.78934262920954 0.0469091467157733 no 3209 0.0367798263309168 4584 4305613
SGTC_2363 9053361 176 µM -1.79222340568558 0.0466470012714089 no 3210 0.0365485934214504 4630 6469797 YMR079W SEC14
SGTC_2838 9002687 71.43 µM -1.80307092089516 0.0456704271457379 no 3211 0.0356885386580875 4611 6457060
SGTC_1685 st024049 53.0905 µM -1.8130801206511 0.0447839678780133 no 3212 0.0349097323921448 4654 1941139
SGTC_1700 st030840 7.9285 µM -1.81646507624228 0.0444873352236545 no 3213 0.0346495302404009 4659 5499307
SGTC_2126 5251174 33.877 µM -1.81959467669679 0.0442144903075779 no 3214 0.0344103764745633 4605 790722
SGTC_1131 3454-3128 32.3 µM -1.82814692521699 0.0434757627507456 no 3215 0.0337637519974047 4604 710982
SGTC_316 k060-0003 58.6 µM -1.82973134570648 0.0433400035067586 no 3216 0.0336450606351818 4673 6152314
SGTC_2123 5259487 200 µM -1.83412384940957 0.0429654260400666 no 3217 0.0333178059692942 4639 2173474
SGTC_1132 3456-3614 2.5 µM -1.83982187428445 0.0424834204953438 no 3218 0.0328971964431253 4597 3125502
SGTC_11 0438-0307 1.3 µM -1.8398266365824 0.0424830194811925 no 3219 0.0328968467449541 4638 4011476
SGTC_2493 resveratrol 26.09 µM -1.8412947649722 0.042359540102258 no 3220 0.032789187241716 4616 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1466 k213-0079 57.5 µM -1.84328010565145 0.0421930216617858 no 3221 0.0326440621360625 4650 3657981
SGTC_1375 2910-0797 186 µM -1.84440248210325 0.0420991180937982 no 3222 0.0325622529298547 4637 742508
SGTC_543 3844-1095 191 µM -1.847838791247 0.0418126707200712 no 3223 0.0323128336836994 4660 4230703
SGTC_1213 1315-0166 115 µM -1.84944316025463 0.0416794736061971 no 3224 0.0321969240562154 4626 768401
SGTC_2349 9023730 187.07 µM -1.85190332542408 0.0414758947916984 no 3225 0.0320198531732422 4648 4126287
SGTC_1963 st076565 50.3 µM -1.86030333150758 0.0407868587698347 no 3226 0.0314213112429555 4667 4914280
SGTC_786 4544-0069 423 µM -1.86947011487353 0.0400455542871841 no 3227 0.0307787188409988 4638 748821 YLR208W SEC13
SGTC_2060 5238662 140 µM -1.87143923190498 0.039887751746482 no 3228 0.030642112680937 4618 790130
SGTC_1648 st011736 69.8 µM -1.87324191104854 0.0397437308358384 no 3229 0.0305174936353313 4639 2855514
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.87459070385936 0.039636248875878 no 3230 0.0304245265275632 4662 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1936 st074407 74.3 µM -1.8772265000684 0.0394268911275167 no 3231 0.030243528481408 4666 809813
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.88015460392442 0.0391953715160575 no 3232 0.0300435052294157 4652 5393153
SGTC_186 3455-3465 67.277 µM -1.8917242456204 0.0382913828316973 no 3233 0.0292638655830963 4686 755278
SGTC_2394 5221648 200 µM -1.89862184075575 0.0377605796982437 no 3234 0.0288071073267656 4652 788586
SGTC_381 3461-2219 42.7 µM -1.90872706005826 0.0369937934669781 no 3235 0.0281486552404761 4639 2883159
SGTC_2571 chrysanthemic acid 100 µM -1.91217047521996 0.0367354322003693 no 3236 0.0279271658773139 4639 2743 An insecticide.
SGTC_1851 st056236 18.9 µM -1.91473318329633 0.0365441102361267 no 3237 0.0277632697160474 4646 5393171
SGTC_284 0988-0104 32.6 µM -1.92609847134927 0.0357054225797732 no 3238 0.027046039737482 4643 4666532
SGTC_1147 3809-1045 12.3 µM -1.92718000208776 0.0356264410308975 no 3239 0.0269786006426472 4681 325925
SGTC_3296 9122258 64.045 µM -1.92834648975552 0.035541415865807 no 3240 0.026906021428521 4640 4730474
SGTC_403 arphamenine a 50 µM -1.93132488938254 0.0353250750734334 no 3241 0.0267214436429394 4682 5487158 An arginine aminopeptidase inhibitor.
SGTC_2053 5265679 138 µM -1.93223979815707 0.035258836478071 no 3242 0.0266649575530854 4577 764595
SGTC_2159 5658611 73.75 µM -1.93753864488239 0.0348772056683157 no 3243 0.0263397671053077 4654 793844
SGTC_965 1291-5240 308 µM -1.94073626099925 0.034648553708134 no 3244 0.0261451378566796 4659 2834598
SGTC_1948 st076329 66.6 µM -1.94937570400521 0.0340369238848185 no 3245 0.0256252869108201 4598 24208413
SGTC_53 0973-0023 39.979 µM -1.95042962981328 0.0339629224968483 no 3246 0.0255624665820851 4598 674768
SGTC_910 3454-3003 490 µM -1.95550869624384 0.0336081490891874 no 3247 0.0252615289725787 4592 820824
SGTC_3036 9090181 49.47 µM -1.95961614523753 0.0333234789946189 no 3248 0.0250203364233232 4721 25236586
SGTC_3022 9087993 49.47 µM -1.97061247609542 0.032571131072528 no 3249 0.0243841092467651 4735 17173644
SGTC_1796 st049173 110.4 µM -1.97187886167433 0.0324853941496961 no 3250 0.0243117184599679 4668 94134
SGTC_2885 9057732 51.95 µM -1.97708748642871 0.0321347148884339 no 3251 0.0240158710015595 4675 6471414
SGTC_1840 st055363 71 µM -1.98384121008514 0.0316846684027331 no 3252 0.0236367722278432 4684 676033
SGTC_2017 5132927 60.65 µM -1.98392746918161 0.0316789542319946 no 3253 0.0236319630870067 4642 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_373 0844-0104 25.9 µM -2.0108444796641 0.0299369948619578 no 3254 0.0221709431294629 4695 5375804
SGTC_1468 k284-1086 134 µM -2.01186163681563 0.0298727581991117 no 3255 0.0221172621926479 4675 15996457
SGTC_254 nsc-64875 3.808 µM -2.02676387940314 0.0289446713335937 no 3256 0.0213432830494562 4686 56993
SGTC_263 alizarin 107.927 µM -2.02885131580428 0.0288166033723628 no 3257 0.0212367183619595 4710 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_939 1165-0479 45.3 µM -2.03289290648751 0.0285699834426754 no 3258 0.0210316719292905 4677 1377347
SGTC_1562 morin hydrate 59.1 µM -2.03872003363466 0.0282175016244584 no 3259 0.020738988578342 4691 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_944 3370-0224 231 µM -2.04784759653289 0.0276726580131132 no 3260 0.0202874674722505 4671 4580514
SGTC_2815 7968870 71.43 µM -2.05438544459219 0.0272878126332196 no 3261 0.019969200350578 4635 2977326 YHR190W ERG9
SGTC_568 1193-0097 7.48 µM -2.07136874934521 0.0263089177221868 no 3262 0.0191621745016846 4515 3646150
SGTC_1675 st018485 24.5 µM -2.09678482274648 0.0248989261014882 no 3263 0.0180063138597428 4689 3323024
SGTC_2008 4012253 172 µM -2.10102623737037 0.0246699109861707 no 3264 0.0178193315639243 4687 603940
SGTC_280 3448-3607 3.04 µM -2.10300831041137 0.0245634964227485 no 3265 0.0177325215239498 4688 626179
SGTC_3259 9138485 49.47 µM -2.10549850719787 0.0244303477087712 no 3266 0.017623968563861 4680 17646153
SGTC_1569 carminic acid 40.6 µM -2.10662077551477 0.0243705393243404 no 3267 0.0175752322098894 4728 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2043 5101342 149 µM -2.12175040723418 0.0235761728953171 no 3268 0.0169293516027554 4715 678451
SGTC_2118 5526350 200 µM -2.14382428438468 0.0224563516966192 no 3269 0.0160234843818042 4714 743594
SGTC_790 1575-0012 79.1 µM -2.14786462075859 0.0222563172833964 no 3270 0.0158622558292127 4716 378741 YLR208W SEC13
SGTC_357 1325-0123 420 µM -2.16109453917009 0.0216118031137474 no 3271 0.0153440186638685 4710 1098503
SGTC_1180 1193-0155 285 µM -2.1622707187859 0.0215552750910523 no 3272 0.015298657667017 4745 2921347
SGTC_2245 6637752 200 µM -2.17628505381174 0.0208912962940477 no 3273 0.0147669762162745 4719 681890
SGTC_1597 7-benzyloxygramine 47.5 µM -2.18069546864112 0.0206859525053815 no 3274 0.0146029742162129 4631 260807
SGTC_2511 berberine 10.47 µM -2.19979051377084 0.0198165215168084 no 3275 0.0139108806648561 4714 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1962 st076595 64.5 µM -2.24131341096385 0.018032477976139 no 3276 0.0125028904329245 4705 279619
SGTC_2950 9072895 21.46 µM -2.24331619256441 0.0179500061097595 no 3277 0.0124382159587059 4669 17332245
SGTC_182 3448-4371 550.524 µM -2.24364597719132 0.017936456909019 no 3278 0.0124275942744972 4683 3491403
SGTC_2516 gossypol 71.55 µM -2.25613574968206 0.0174296961778517 no 3279 0.0120310654215639 4737 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2698 st077697 67.5 µM -2.26261207417902 0.0171717734989747 no 3280 0.0118298065848366 4706 3154499
SGTC_2708 st078559 56 µM -2.27806600723297 0.0165694577365385 no 3281 0.0113613225877234 4725 17250902
SGTC_443 clozapine 122 µM -2.28092072734808 0.0164601967886624 no 3282 0.0112765690939477 4734 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2913 7966556 36.57 µM -2.28144480631946 0.0164402054582869 no 3283 0.0112610696137341 4655 2976516
SGTC_2081 5214970 32.255 µM -2.28743476757476 0.0162131871760357 no 3284 0.0110852294491961 4709 2063512
SGTC_1821 st053465 65.6 µM -2.28745736927342 0.0162123356879807 no 3285 0.0110845705061849 4749 675086
SGTC_841 0251-0215 91.2 µM -2.30642355970394 0.0155111827376752 no 3286 0.0105434884044725 4757 3888614
SGTC_277 nystatin 15.5 µM -2.30984314180535 0.0153875749531587 no 3287 0.0104484199293364 4744 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2718 lomofungin 53.02 µM -2.31148473141605 0.0153285374213798 no 3288 0.0104030477845298 4714 5351222 A RNA synthesis inhibitor.
SGTC_1672 st016598 6.51 µM -2.31643875346171 0.0151515506195178 no 3289 0.0102671624356869 4721 4665860 YNL267W PIK1
SGTC_402 epigallocatechin gallate 10 µM -2.33061562678652 0.0146547393456613 no 3290 0.00988681837037383 4733 65064 An antioxidant.
SGTC_2453 5731132 22.18 µM -2.36459579310523 0.01352066547037 no 3291 0.00902487938359971 4754 1362040
SGTC_2343 7990716 14.84 µM -2.36481600704719 0.0135135702489666 no 3292 0.00901951520094717 4733 6456862
SGTC_942 3253-1115 227 µM -2.36526126130164 0.0134992341206929 no 3293 0.00900867780098361 4752 46497897
SGTC_657 3534-0529 86.7 µM -2.36896700303793 0.0133804265663899 no 3294 0.00891892240393836 4761 1049549
SGTC_2952 9073731 13.78 µM -2.386693534264 0.0128245170893668 no 3295 0.00850032829244939 4722 16457353
SGTC_736 0958-0254 92.6 µM -2.39582194752309 0.0125461213799842 no 3296 0.00829157185098898 4764 6812352
SGTC_2166 5933061 31.504 µM -2.41245057284684 0.0120524158658212 no 3297 0.0079228428855154 4696 2877375
SGTC_398 bronopol 33.3 µM -2.41340596156953 0.0120245692230522 no 3298 0.00790210279564508 4718 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_292 k038-0015 474 µM -2.43913946825759 0.0112952214758356 no 3299 0.00736114252663903 4759 46368540
SGTC_2356 9061756 188.97 µM -2.44031967159706 0.0112627143191626 no 3300 0.0073371350912266 4764 20104043
SGTC_1170 0310-0127 64.8 µM -2.45660279093549 0.0108224494767375 no 3301 0.00701288351852053 4755 774975
SGTC_650 1328-0195 38 µM -2.46818021691896 0.0105186013738476 no 3302 0.00679009650236431 4753 2780821
SGTC_1792 st045773 43.6 µM -2.49182370995925 0.00992109363427515 no 3303 0.0063544549506808 4756 2919270
SGTC_1644 st010134 20.9 µM -2.49314049042126 0.00988870561145595 no 3304 0.0063309367803998 4756 3818134
SGTC_1319 1306-0155 43.7 µM -2.49355041557627 0.00987864180196305 no 3305 0.00632363111358071 4768 3122360
SGTC_2969 9091408 28.7 µM -2.49815028450122 0.00976632518196837 no 3306 0.00624216275719919 4719 4286311
SGTC_1620 st003704 16.5 µM -2.50018622795762 0.00971697002728024 no 3307 0.00620640182594611 4752 2834414
SGTC_283 0987-0079 11.7 µM -2.50841752444583 0.00951964254358624 no 3308 0.00606366376365126 4773 411556
SGTC_3188 9110789 49.47 µM -2.51024424773914 0.00947632888212012 no 3309 0.00603238402545118 4742 849217
SGTC_2603 homopterocarpin 100 µM -2.54694675760394 0.00864185630717682 no 3310 0.00543350058918822 4736 101795 A weak amylase inhibitor.
SGTC_147 4466-0538 29.23 µM -2.57818435268902 0.00798313272909095 no 3311 0.00496604970487741 4748 6742687 YHR072W ERG7
SGTC_321 4534-3890 65.3 µM -2.57957048297249 0.00795495426460779 no 3312 0.00494616345114126 4778 699746
SGTC_446 go6976 132 µM -2.58701779442752 0.00780505115169115 no 3313 0.00484052962515681 4771 3501 A protein kinase C inhibitor.
SGTC_2049 5262831 67.185 µM -2.58967441608524 0.00775218196263773 no 3314 0.00480333717069571 4737 763417
SGTC_1753 st043925 64 µM -2.59052986364219 0.00773522498740997 no 3315 0.0047914153322259 4772 670181
SGTC_2961 9083290 32.55 µM -2.60026981393388 0.0075444459833596 no 3316 0.00465752443458435 4745 17741490
SGTC_1133 3473-0247 50 µM -2.61474011437298 0.00726866430044265 no 3317 0.00446476854386055 4737 711311
SGTC_2113 5491891 107.031 µM -2.62084778247343 0.00715495490056688 no 3318 0.00438557076037775 4763 789979
SGTC_1311 1190-0148 100 µM -2.62479770712278 0.00708225548357108 no 3319 0.00433502305784572 4779 1961333
SGTC_2018 5133068 143 µM -2.66931144678256 0.00630694134546468 no 3320 0.00380034676034313 4756 785362
SGTC_2594 a-mangostin 100 µM -2.6867424264819 0.00602443681370842 no 3321 0.00360762840828335 4751 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1590 st077108 57.8 µM -2.69648616266713 0.0058714568458595 no 3322 0.00350376544914623 4788 5489485
SGTC_174 3553-0389 74.3 µM -2.69830199547108 0.00584333164926938 no 3323 0.00348470921296248 4774 738071
SGTC_2875 9039966 71.43 µM -2.69847365052435 0.00584067909977049 no 3324 0.00348291260573668 4778 6463691
SGTC_3067 9117431 49.47 µM -2.72160897907011 0.00549280150975914 no 3325 0.00324824804644938 4771 17150885
SGTC_2686 alizarin 95.37 µM -2.7261856617103 0.00542620666740395 no 3326 0.00320354737763522 4766 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1791 st048313 56.1 µM -2.72968758830917 0.00537573613944648 no 3327 0.00316971852061817 4781 1204976
SGTC_3074 9116018 49.47 µM -2.74231557755063 0.00519718731605025 no 3328 0.00305038488550277 4778 17027303
SGTC_899 1083-0020 478 µM -2.76872581912524 0.00484073347605853 no 3329 0.00281379858429306 4785 767123
SGTC_1715 st032160 10.2275 µM -2.77377832316639 0.00477507934518878 no 3330 0.0027704710295837 4722 5289825
SGTC_1660 st012960 28.1 µM -2.83269446883935 0.00406608591574673 no 3331 0.00230787402181211 4789 24207266
SGTC_1760 st045453 10.4495 µM -2.84676569060471 0.00391136115848007 no 3332 0.0022082928347213 4787 3323419 YIL048W NEO1
SGTC_2451 5856223 45.7 µM -2.85998502149174 0.00377083108423785 no 3333 0.00211830508885333 4770 2179896
SGTC_110 0850-0284 111.64 µM -2.88004571973095 0.00356621093136524 no 3334 0.00198808753204299 4779 3906265
SGTC_1029 k015-0030 64.7 µM -2.94327982501659 0.0029848331364824 no 3335 0.00162377366735705 4788 2208316
SGTC_852 0418-0143 439 µM -2.94603892321692 0.0029615309804215 no 3336 0.00160935946995591 4780 5369229
SGTC_3159 9100096 49.47 µM -3.00414922767242 0.00250735094344252 no 3337 0.00133162331108685 4766 25236875
SGTC_1026 k007-1105 30.6 µM -3.0156179063232 0.00242553367345498 no 3338 0.00128228104220144 4766 7066794
SGTC_3063 1327-0034 4 µM -3.01603911400982 0.00242257530607294 no 3339 0.00128050110736536 4733 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1399 3562-5772 25 µM -3.08497114242524 0.00198018890079832 no 3340 0.00101785951875334 4785 23847490
SGTC_2374 9071832 200 µM -3.12789189734256 0.00174319152229008 no 3341 0.000880324625272643 4791 17381698
SGTC_569 4130-2812 160 µM -3.13013441837771 0.00173154959150506 no 3342 0.000873631656008552 4783 743552
SGTC_859 0439-0102 54.6 µM -3.13088634055128 0.00172766189697583 no 3343 0.000871397983977038 4800 610143
SGTC_1749 st037932 54.2 µM -3.1359293037997 0.0017017927117639 no 3344 0.000856552471116009 4779 594497
SGTC_291 SEC14.278 35.5 µM -3.22597989426858 0.00129542887221491 no 3345 0.000627710878732766 4803 1068044
SGTC_2947 9072639 7.68 µM -3.2341761746408 0.00126324564994657 no 3346 0.000609970886576956 4774 16488146
SGTC_2523 spermine 47.74 µM -3.44901241352249 0.00064078160762373 yes 3347 0.000281320418047253 4800 1103 A DNA binding polyamine.
SGTC_715 0868-0130 184 µM -3.48354419320179 0.000572553156776378 yes 3348 0.000247410709879115 4808 2876258
SGTC_832 4083-0019 164 µM -3.49741341265902 0.00054709138495289 yes 3349 0.00023489659501202 4800 1990758
SGTC_3030 9087619 49.47 µM -3.49889843362272 0.000544428093684797 yes 3350 0.000233592252311478 4799 25236973
SGTC_1750 st081859 2.357 µM -3.53526397051281 0.000482835030320085 yes 3351 0.000203683995955778 4777 5291695
SGTC_111 0083-0039 52.457 µM -3.53874893458153 0.000477284637461495 yes 3352 0.000201014010615896 4804 759313
SGTC_2398 5228213 48.84 µM -3.54946246114144 0.000460589482613854 yes 3353 0.000193009249193752 4794 80771 YMR134W ERG29
SGTC_1523 st012844 44.7 µM -3.72635559857056 0.000252423230974676 yes 3354 9.71341415870155e-05 4805 4274103
SGTC_2964 9083345 53.42 µM -3.89600809893941 0.000138425324786696 yes 3355 4.88955600105177e-05 4793 17741579
SGTC_2108 5365811 200 µM -5.04307998767729 1.27861510392175e-06 yes 3356 2.29048820361413e-07 4810 780283