SGTCid condition conc unit RRP12|YPL012W.score RRP12|YPL012W.strain.pval RRP12|YPL012W.strain.significant RRP12|YPL012W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3147 9097027 49.47 µM 3.90391885733961 5.00945322246588e-05 yes 1 4.73237624809837e-05 7 25236841
SGTC_423 5-fluorouracil 457 µM 3.75213319819749 9.25464585633664e-05 yes 2 8.76681297231227e-05 31 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_76 0433-0009 400.328 µM 3.73577384984994 9.87472271529821e-05 yes 3 9.35693986481759e-05 10 2841569
SGTC_3326 9140064 16.379 µM 3.57157169633315 0.000186699330136411 yes 4 0.000177422688735925 7 1868434
SGTC_2427 5545055 42.75 µM 3.46882846681731 0.000274544485077908 yes 5 0.000261366546216737 11 5372858
SGTC_738 1315-0003 72.4 µM 3.4357188184432 0.000310214896952179 yes 6 0.000295491996820557 9 6251474
SGTC_3217 9129673 49.47 µM 3.42116652929127 0.000327218333434166 yes 7 0.000311765697708372 17 17248312
SGTC_2490 carminic acid 95.39 µM 3.41938945116372 0.00032935310867598 yes 8 0.00031380914432967 11 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1753 st043925 64 µM 3.26883413182607 0.000565271983773438 yes 9 0.000539957937254416 7 670181
SGTC_1244 0416-0015 52.5 µM 3.22036664297184 0.000669607349109504 yes 10 0.000640133712568619 7 96201
SGTC_812 4251-0442 148 µM 3.18946650755214 0.000745113780482819 yes 11 0.000712678272812711 10 5723007
SGTC_1466 k213-0079 57.5 µM 3.18237937876275 0.000763502981148428 yes 12 0.000730351725888484 22 3657981
SGTC_2492 derrusnin 100 µM 3.16073026556427 0.000822296641499922 yes 13 0.00078687079779065 11 1715307 Part of coumarin class of compounds.
SGTC_3346 9158254 43.5805 µM 3.06601681217145 0.00113175262738769 no 14 0.00108465558393223 29 17639500
SGTC_701 4424-0219 185 µM 3.03933465842987 0.00123645429619736 no 15 0.00118550655213584 8 2911779
SGTC_1193 1488-0126 41.5 µM 3.03749193453019 0.00124400260514048 no 16 0.00119277894287583 12 1384710
SGTC_877 0771-0151 33.1 µM 2.8756307476268 0.00209733356100849 no 17 0.00201610554787711 12 6166523
SGTC_2419 paclitaxel 166.5 µM 2.8285010051268 0.00243076591215617 no 18 0.0023383277116453 19 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_524 r073-0010 27.8 µM 2.8173677826234 0.00251622583841089 no 19 0.00242095228190557 36 2772106
SGTC_924 2046-0044 21.3 µM 2.80281536198493 0.00263202565787096 no 20 0.00253293310379621 23 3623589
SGTC_3135 9127742 49.47 µM 2.78328268154242 0.00279502010074526 no 21 0.00269059493365436 16 3643468
SGTC_1425 4048-4433 7.33 µM 2.78176182520612 0.00280808558371543 no 22 0.0027032350539493 15 23734946
SGTC_1300 1094-0077 113 µM 2.74070063243788 0.00318232714913913 no 23 0.00306541694288073 20 5532636
SGTC_2566 crystal violet carbinol 226 nM 2.70511958175821 0.00354229013620033 no 24 0.00341399024359332 50 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1607 st000305 50.6 µM 2.70185694390627 0.00357706113075226 no 25 0.00344767115249997 17 5457690
SGTC_2674 ligustilide 100 µM 2.67905055445803 0.00382879406064335 no 26 0.00369156229496146 16 5319022 A signalling regulator.
SGTC_1501 4491-0275 38.4 µM 2.67787008756571 0.00384224586883477 no 27 0.00370459748061949 17 5104718
SGTC_752 1896-0090 130 µM 2.66472366754509 0.00399494139422361 no 28 0.00385258040716656 23 772567
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.64940369513492 0.00417972158790088 no 29 0.00403169748647966 20 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_811 0416-0114 265 µM 2.62099577155018 0.00454269590834747 no 30 0.00438366746944678 25 6612453
SGTC_3028 9087778 49.47 µM 2.57982236902739 0.00511874825578415 no 31 0.00494255737053197 16 17217395
SGTC_792 4534-1957 155 µM 2.55673638476903 0.00546943504885424 no 32 0.00528296275748742 18 1717904
SGTC_1112 tnp00069 1.16933 µM 2.5264030021503 0.00596259492399086 no 33 0.00576186027591271 15 145826
SGTC_1690 st023502 41.2 µM 2.50862868474138 0.00626954376111123 no 34 0.00606004064582504 22 24207482
SGTC_966 1300-0360 30.2 µM 2.48574066741909 0.00668536373243814 no 35 0.0064641069108377 48 70588
SGTC_1207 2099-0101 141 µM 2.48553096682932 0.00668928356886688 no 36 0.00646791660730639 18 5837381
SGTC_1301 naphtanilide LB 4.81 µM 2.46263455829371 0.00712968661279318 no 37 0.00689602050192748 43 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2597 laccaic acid a 100 µM 2.46191103752843 0.00714401073767743 no 38 0.00690994705287655 37 5491415 A textile dye.
SGTC_1065 prochlorperazine maleate 2.48 µM 2.45844601280651 0.00721296313063824 no 39 0.00697698774987556 31 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_627 1391-0720 175 µM 2.44883656493404 0.00740726693536376 no 40 0.00716592312809374 34 997839
SGTC_1241 0364-0022 50.8 µM 2.44270362879086 0.0075336733587356 no 41 0.00728885157879058 34 4563895
SGTC_181 1447-1644 8.07 µM 2.43582279408055 0.0076777529878147 no 42 0.00742898065520754 38 534600
SGTC_3141 9094609 49.47 µM 2.39850743241049 0.00850212891854398 no 43 0.00823102120131476 44 25236309 YDL196W YDL196W
SGTC_750 4073-0104 132 µM 2.38386175232628 0.00884632312173586 no 44 0.00856601849355555 12 22330957
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.36024350817165 0.0094271341234288 no 45 0.0091314713383864 35 5024745
SGTC_3353 9151644 39.2805 µM 2.35060070964054 0.00967369098860078 no 46 0.00937156739545378 22 4909158
SGTC_1357 1503-1303 39.5 µM 2.34932550287742 0.00970671501071299 no 47 0.00940372863814385 41 292895
SGTC_758 0868-0029 16 µM 2.34769418833533 0.00974910472919055 no 48 0.00944501177699515 19 762687
SGTC_707 0865-0008 204 µM 2.33914436742128 0.00997392699386569 no 49 0.00966398157405241 28 723043
SGTC_2783 7738165 71.43 µM 2.33695198016887 0.010032301038515 no 50 0.00972084054616405 34 17201110
SGTC_2811 7967822 32.47 µM 2.33453239144766 0.01009707041849 no 51 0.00978393100992881 34 2232244
SGTC_2394 5221648 200 µM 2.324881951856 0.0103590440479494 no 52 0.0100391366473725 34 788586
SGTC_2271 7849410 118.62 µM 2.31261414493483 0.0107006094990345 no 53 0.0103719315665249 21 972430
SGTC_1208 2323-2347 50.3 µM 2.30388499789809 0.0109495836470822 no 54 0.0106145500311566 20 5412760
SGTC_1529 apigenin 74 µM 2.30249167236073 0.0109897872721463 no 55 0.0106537302580323 30 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1819 st053448 58.6 µM 2.27903099459148 0.0116862732957772 no 56 0.0113326114536257 31 2857616
SGTC_2018 5133068 143 µM 2.27505033438596 0.011808174719851 no 57 0.0114514552625876 44 785362
SGTC_3175 9106517 49.47 µM 2.26990363843178 0.0119674185420386 no 58 0.0116067151586131 30 41468073
SGTC_1302 1159-0335 255 µM 2.26219608354424 0.0122093802093845 no 59 0.0118426455941104 30 649284
SGTC_3333 9141820 12.094 µM 2.26190336362913 0.0122186524725223 no 60 0.0118516872581825 38 1939433
SGTC_71 0417-1750 47.813 µM 2.2485858539666 0.0126470053467627 no 61 0.0122694286259863 45 6811472
SGTC_2313 7726885 200 µM 2.24524575495237 0.0127564553729695 no 62 0.0123761801323473 52 726423
SGTC_1470 k295-0292 231 µM 2.23581572157851 0.0130698971952567 no 63 0.0126819223380338 35 5045612
SGTC_1287 0971-0001 34.6 µM 2.23544654968661 0.0130823022159944 no 64 0.0126940234890026 47 4665869
SGTC_1701 st028638 40.4 µM 2.22985515893772 0.0132714337177492 no 65 0.0128785300578509 27 3490878
SGTC_2464 5717415 7.67 µM 2.228819961563 0.0133067077005949 no 66 0.0129129431147373 29 5285744
SGTC_1211 1056-0033 32.3 µM 2.21497758995353 0.0137862187556207 no 67 0.0133808013742999 31 6741922
SGTC_146 3448-8650 53.125 µM 2.21143467091794 0.013911317775386 no 68 0.0135028755759882 51 2891488 YIL048W NEO1
SGTC_1131 3454-3128 32.3 µM 2.20646720899858 0.0140883643349982 no 69 0.0136756518659938 50 710982
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.18377837237066 0.0149219232592623 no 70 0.0144892687848093 45 65057 A dermal irritant. YDR527W RBA50
SGTC_1077 5-fluorocytosine 377 nM 2.18111078662367 0.0150226582718781 no 71 0.0145876116049466 57 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2091 4-phenylthiadiazole 200 µM 2.17685881626584 0.015184432046549 no 72 0.0147455515199283 32 270010
SGTC_1226 3909-7979 35.4 µM 2.1719063968242 0.0153747403043163 no 73 0.0149313619440727 54 6615510
SGTC_2649 anisomycin 9.56 µM 2.17010679442364 0.0154443997359467 no 74 0.0149993782983032 42 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1076 itraconazole 331 nM 2.15419088634828 0.0160723578054877 no 75 0.0156126026420364 44 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3137 9097352 49.47 µM 2.14683334254948 0.0163699656647526 no 76 0.0159032759252504 53 44120435
SGTC_1189 1431-2119 7.28 µM 2.13431119645152 0.0168873308284987 no 77 0.0164086576795923 59 3107275
SGTC_1758 st042942 75.2445 µM 2.13399405222271 0.0169006134728715 no 78 0.0164216338472849 47 669317
SGTC_2990 9074105 71.4286 µM 2.11142756556253 0.017868956530711 no 79 0.0173677888991996 43 6502001
SGTC_2014 4013930 200 µM 2.10367066414859 0.0182125615239941 no 80 0.0177035925749433 49 64556
SGTC_783 0848-0141 92.7 µM 2.09982600906122 0.0183849436611087 no 81 0.0178720747081878 55 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1156 4092-0367 4.88 µM 2.09248368343433 0.0187180135276179 no 82 0.0181976349225158 55 1357585
SGTC_2722 naftopidil 47.16 µM 2.09181928791195 0.0187484042888282 no 83 0.0182273421464929 34 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3067 9117431 49.47 µM 2.09139053663498 0.0187680385017796 no 84 0.018246534902469 67 17150885
SGTC_1409 3909-8004 61.9 µM 2.07803397915223 0.0193885098772305 no 85 0.01885311481481 43 2119279
SGTC_1986 st071812 45 µM 2.07543555500567 0.0195112218774436 no 86 0.0189730929110949 28 11838594
SGTC_762 1165-0429 115 µM 2.07453962828021 0.0195536851622985 no 87 0.0190146111762495 47 5967793
SGTC_3201 9113999 49.47 µM 2.07434196172077 0.0195630643147255 no 88 0.0190237816663792 49 16649224
SGTC_1715 st032160 10.2275 µM 2.0720350655803 0.0196728078508152 no 89 0.0191310855807305 43 5289825
SGTC_261 5-fluorouridine 15.376 µM 2.07104233665601 0.019720194511177 no 90 0.0191774199010911 47 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2343 7990716 14.84 µM 2.06813439555563 0.0198595593958589 no 91 0.0193136935795285 48 6456862
SGTC_1756 st041558 35.5 µM 2.06330987185029 0.020092621257982 no 92 0.0195415983717085 45 3955792
SGTC_3082 9117008 49.47 µM 2.05853608444748 0.0203255113394044 no 93 0.0197693505414652 32 41448529
SGTC_1522 st012842 45.6 µM 2.04841391051095 0.0208269006964478 no 94 0.0202597298311933 53 3491067 YOR116C RPO31
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.04642148937803 0.0209268164454103 no 95 0.0203574597949639 46 442882
SGTC_162 k030-0015 37.8 µM 2.04144529855504 0.0211781354670017 no 96 0.0206032928993601 36 1809920 YMR134W ERG29
SGTC_1411 3909-8223 150 µM 2.04108002349743 0.0211966835871793 no 97 0.0206214368192268 53 X1411
SGTC_1209 2323-2347 50.3 µM 2.02338539355385 0.0221117895274389 no 98 0.0215167144637268 45 5412760
SGTC_1914 st062367 72.6 µM 2.02249586603013 0.0221586598432831 no 99 0.0215625751215942 60 978205
SGTC_2234 tolnaftate 200 µM 2.01456239119651 0.0225804050224167 no 100 0.0219752607096357 17 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1623 st003709 20.3 µM 2.01181181937849 0.0227281970915413 no 101 0.0221198887737069 44 16192618
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.98163746963185 0.0244037151916551 no 102 0.0237599151705822 44 91467 include heat shock
SGTC_2353 9059630 146.67 µM 1.96670381226333 0.0252705821188846 no 103 0.0246086835706912 33 4779114
SGTC_2426 5582046 32.21 µM 1.96496792411182 0.0253730004181357 no 104 0.0247089750721755 57 2251934
SGTC_1751 st044839 27.194 µM 1.96062262587948 0.0256309007443716 no 105 0.0249615304994602 41 5291326
SGTC_2190 6049624 200 µM 1.94053062445809 0.0268520947416395 no 106 0.0261576180473304 44 2265554
SGTC_1734 st037168 69.4 µM 1.93421337427131 0.0272459536006045 no 107 0.0265434493401427 60 708907
SGTC_170 4197-0004 226 µM 1.93418192360679 0.0272479264328853 no 108 0.0265453820465551 70 218692
SGTC_1359 1582-0056 520 nM 1.93231534327487 0.0273652265715445 no 109 0.0266602978896245 51 3661189
SGTC_2546 rhodinyl acetate 100 µM 1.9310743956506 0.0274434433550607 no 110 0.0267369264369314 60 6708682
SGTC_2465 5809242 33.21 µM 1.92865774789367 0.0275962994160191 no 111 0.0268866824270055 47 2731748
SGTC_2153 5569715 200 µM 1.92480848696366 0.0278412351383814 no 112 0.0271266609258072 59 2054701
SGTC_2287 7945887 168.79 µM 1.92312266019673 0.027949076361975 no 113 0.0272323235690458 54 1245853
SGTC_520 3584-0023 682 µM 1.90599517934179 0.0290645616848546 no 114 0.0283254155488372 66 1340790
SGTC_832 4083-0019 164 µM 1.89597346867867 0.0297342450294263 no 115 0.028981776448439 101 1990758
SGTC_610 4215-0184 155 µM 1.89484750365987 0.0298102793845853 no 116 0.0290563038519146 69 5605015
SGTC_2470 5664817 21.68 µM 1.89455941365089 0.0298297594683306 no 117 0.0290753980369467 44 2859561
SGTC_379 3970-0972 5.9 µM 1.89304772717788 0.0299321499133929 no 118 0.0291757613675521 60 2898042 YBL034C STU1
SGTC_2228 7354201 200 µM 1.89005443622157 0.0301357533555613 no 119 0.0293753400181587 50 753451
SGTC_1489 4065-0444 182 µM 1.88757736767078 0.0303051103753226 no 120 0.0295413554042811 45 2877968
SGTC_94 0334-0113 514.748 µM 1.88277315413611 0.0306358226230848 no 121 0.0298655583424947 49 6795178
SGTC_2857 9024691 58.44 µM 1.87946897454388 0.0308650058405387 no 122 0.0300902429965108 57 16478292
SGTC_2804 7954240 19.48 µM 1.87858470028643 0.0309265806789402 no 123 0.0301506109191596 70 828705
SGTC_1452 4194-0072 190 µM 1.87167124351312 0.0314114994798655 no 124 0.0306260501486301 64 1343545
SGTC_2328 6201408 200 µM 1.86229804941334 0.0320789703534689 no 125 0.0312805451406707 83 2890418
SGTC_2333 9017922 200 µM 1.84559553914183 0.033297377464895 no 126 0.0324754773567018 56 3163164
SGTC_1184 1269-1718 139 µM 1.84232534886903 0.0335403361524888 no 127 0.0327137870181181 69 5403821
SGTC_2818 7996756 12.99 µM 1.84083483623707 0.0336515568886075 no 128 0.0328228830431037 59 2241621
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.83762882941724 0.0338918149899542 no 129 0.0330585588309468 72 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2217 6934799 96.0675 µM 1.83691490086322 0.0339455084245423 no 130 0.0331112295906364 44 675606
SGTC_3014 9081533 49.47 µM 1.83242380890432 0.0342848828307205 no 131 0.0334441517754668 71 21367265
SGTC_2279 7948423 32.93 µM 1.83138129287443 0.0343640592361961 no 132 0.0335218257633821 59 1247112
SGTC_1645 Cervolide 78 µM 1.82596330694994 0.0347779644253781 no 133 0.0339278945491382 61 23173 A fragrance.
SGTC_962 1254-0300 21.5 µM 1.8250351741392 0.0348492778342292 no 134 0.0339978607758069 49 7340576
SGTC_169 k015-0017 16.025 µM 1.81803295623987 0.0353911735373343 no 135 0.0345295479232383 59 1840002
SGTC_3019 9081971 49.47 µM 1.81772702035678 0.035415006330393 no 136 0.0345529328859694 58 16451803
SGTC_2159 5658611 73.75 µM 1.81514649363447 0.0356165567492752 no 137 0.0347506999060734 63 793844
SGTC_1993 st073995 70.8 µM 1.81336898522217 0.0357559340617941 no 138 0.03488746490139 64 3098394
SGTC_3243 9134147 49.47 µM 1.81334823945258 0.0357575634061029 no 139 0.0348890637265572 51 24282180
SGTC_1479 0549-0158 134 µM 1.80891921617116 0.0361068084077158 no 140 0.0352317772881874 64 5440202
SGTC_2244 6635614 200 µM 1.80757435932971 0.0362134065686603 no 141 0.0353363859402519 36 836499
SGTC_3074 9116018 49.47 µM 1.79581093494019 0.0371568425304273 no 142 0.0362622955242205 62 17027303
SGTC_880 0833-0487 87.2 µM 1.78808261476172 0.0377875226518464 no 143 0.036881340019946 62 76075
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.78606616931325 0.0379535068508332 no 144 0.0370442725124282 65 688761
SGTC_1245 0418-0076 17.2 µM 1.78441181532566 0.0380901292061205 no 145 0.0371783862808936 61 6790114
SGTC_2581 avocatin a 64 µM 1.77817546812858 0.0386087592368779 no 146 0.0376875203474839 66 6710728 A skin care supplement.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.76868618173578 0.039408937270483 no 147 0.0384731297790517 96 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1784 st039334 36.3 µM 1.76355691777593 0.0398470454514078 no 148 0.0389033032619368 78 3496984
SGTC_2352 9027995 87.8 µM 1.7595104391444 0.0401954558393132 no 149 0.0392454243590724 58 2997347
SGTC_2719 novobiocin 32.65 µM 1.75271374060385 0.0407862319559436 no 150 0.0398255779650352 56 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2912 7964298 10.93 µM 1.74309353714051 0.0416344534024748 no 151 0.0406586386744084 100 2975850
SGTC_2281 7943571 200 µM 1.74303051771878 0.0416400566314868 no 152 0.0406641421059358 75 1244024
SGTC_1375 2910-0797 186 µM 1.73507834016424 0.0423520230707829 no 153 0.0413634651054781 66 742508
SGTC_3286 9117135 37.221 µM 1.73148582442935 0.0426768780731768 no 154 0.0416825755149407 71 3438150
SGTC_3146 9095609 49.47 µM 1.7291857806025 0.0428859163173577 no 155 0.0418879252126829 59 17173999
SGTC_551 k048-0028 34.9 µM 1.72083194554732 0.043652119822837 no 156 0.0426406618558301 87 6836383
SGTC_1467 k284-1082 293 µM 1.72006115909181 0.0437233685546092 no 157 0.0427106625185914 70 3334705
SGTC_1928 4'-methoxychalcone 40.3 µM 1.71121062285958 0.0445482227473399 no 158 0.0435211191909958 79 641818
SGTC_2118 5526350 200 µM 1.71085317459313 0.0445817978665105 no 159 0.0435541102650037 79 743594
SGTC_1412 3909-8563 178 µM 1.70746721638747 0.0449008529971876 no 160 0.0438676231052542 65 23767530
SGTC_1842 st055362 61.2 µM 1.70670406182565 0.0449730174601517 no 161 0.0439385359373341 56 676032
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.70088165640571 0.0455266664052024 no 162 0.0444826059068553 65 75037 A free radical scavenger.
SGTC_2528 xanthyletin 44.79 µM 1.69675762079174 0.0459221241069977 no 163 0.044871246970443 70 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1045 1348-1485 165 µM 1.69552554544003 0.0460408029737368 no 164 0.0449878842278713 80 6810614
SGTC_2397 5161689 200 µM 1.69101265231255 0.0464776099557101 no 165 0.0454171931032782 71 2259942
SGTC_2227 7312221 64.1025 µM 1.68899387726469 0.0466740828364485 no 166 0.045610301651918 68 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2306 7482397 179.52 µM 1.6888607574266 0.0466870618192138 no 167 0.0456230585670437 90 891448
SGTC_1289 0976-0073 69.1 µM 1.68844701151467 0.0467274199072638 no 168 0.0456627262789762 73 3391136
SGTC_2203 7227154 166.4 µM 1.68319691311304 0.0472419658987888 no 169 0.0461684891052154 49 896304
SGTC_1940 st075990 51.1 µM 1.68151121963603 0.0474081353611781 no 170 0.0463318295103677 71 1084979
SGTC_3273 9137859 49.47 µM 1.67408498250654 0.0481457702569203 no 171 0.0470569493737656 84 2377234
SGTC_2975 9084847 53.72 µM 1.66780544994766 0.0487766458760748 no 172 0.0476771768306814 84 27211724
SGTC_1140 3229-1848 2.98 µM 1.66477617032291 0.0490833371003104 no 173 0.0479787099132427 62 2849525
SGTC_3341 9147222 25.867 µM 1.6616445842488 0.0494020033194478 no 174 0.0482920291815158 75 1939759
SGTC_1870 st057514 26.5 µM 1.66022642781236 0.0495468554055815 no 175 0.0484344549953496 71 5393161
SGTC_2409 alverine citrate 63.97 µM 1.659430380645 0.0496283129715388 no 176 0.0485145493030759 65 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2622 2-methoxyxanthone 59.94 µM 1.65728690751098 0.0498481806992427 no 177 0.0487307415097905 74 71034 A hepatoprotective.
SGTC_2583 asiatic acid 100 µM 1.65329848262195 0.0502593625757887 no 178 0.0491350658322235 92 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_407 eburnamonine 100 µM 1.65225297742842 0.0503675936782438 no 179 0.0492414953780977 72 3195
SGTC_703 3875-0075 71.8 µM 1.64554830567627 0.0510660851097508 no 180 0.0499283947880768 87 2850814
SGTC_2259 7964009 200 µM 1.64475410720978 0.0511493327695377 no 181 0.0500102648724058 62 313134
SGTC_2683 piperine 63.03 µM 1.63786301862252 0.0518761962080721 no 182 0.050725135986041 79 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3015 9080845 49.47 µM 1.6358898929 0.0520858237978917 no 183 0.0509313168366038 82 5296973
SGTC_2111 5486399 200 µM 1.62527449268463 0.0532251909311972 no 184 0.052052041961529 87 689674
SGTC_1027 k015-0025 8.67 µM 1.62026835917243 0.0537693190802129 no 185 0.0525873213136292 77 3598955
SGTC_2832 7992762 51.95 µM 1.61893763590309 0.0539146971315634 no 186 0.0527303410356064 83 2985177
SGTC_429 1112-0049 25.5 µM 1.61328761075321 0.0545354163034381 no 187 0.053341018464713 81 2836170
SGTC_2799 7812892 81.82 µM 1.6114801664802 0.0547351733076351 no 188 0.0535375533413889 112 20205235
SGTC_1810 st050138 53 µM 1.61087891685965 0.0548017509031206 no 189 0.0536030580431976 98 3444541
SGTC_776 4476-4378 112 µM 1.61022810503286 0.054873888751258 no 190 0.0536740339683365 74 2892008
SGTC_993 3909-8757 62.7 µM 1.60978225053887 0.0549233518457248 no 191 0.0537227007061936 64 4288324 YLR208W SEC13
SGTC_2802 7925815 54.55 µM 1.60425002654297 0.0555400320806991 no 192 0.0543294758191118 94 1262923
SGTC_555 4296-0685 37 µM 1.6014182422119 0.0558578009050527 no 193 0.0546421574932609 93 2908540 YHR072W ERG7
SGTC_2163 5671233 125 µM 1.60138909771898 0.0558610787974307 no 194 0.0546453829694107 101 701023
SGTC_3143 9086658 49.47 µM 1.60030419828345 0.0559832058610551 no 195 0.0547655579826272 97 25236626
SGTC_3250 9135583 49.47 µM 1.59884374337473 0.0561479416465858 no 196 0.0549276633287699 78 7699353
SGTC_2404 5161160 200 µM 1.59878088334661 0.0561550406769842 no 197 0.0549346490730363 117 2831543
SGTC_2883 9059145 45.46 µM 1.59832142885248 0.0562069501756379 no 198 0.0549857303732139 97 16476510
SGTC_1981 st071826 47 µM 1.59808756091073 0.056233387269986 no 199 0.0550117457888436 86 11838600
SGTC_921 1561-0023 372 µM 1.59776303550153 0.0562700887809618 no 200 0.0550478620308054 96 24050882
SGTC_2229 7354935 190 µM 1.59646466702323 0.0564171139483142 no 201 0.0551925441402912 105 318112
SGTC_926 2268-1401 59.4 µM 1.5911947160876 0.0570169854715436 no 202 0.0557828808318047 90 2931578
SGTC_802 4112-3352 742 µM 1.58935168011144 0.0572279570627869 no 203 0.0559905085664262 78 704594
SGTC_550 4123-0385 25.7 µM 1.58795921944246 0.0573877585264821 no 204 0.0561477804810199 79 5731123
SGTC_1427 4048-4900 550 nM 1.57388639344456 0.0590225534532468 no 205 0.0577568580599436 88 24132586
SGTC_82 0054-0107 293.755 µM 1.57372664187264 0.0590413188246869 no 206 0.057775329909432 78 3104697
SGTC_1078 idebenone 36.1 µM 1.57096155269683 0.0593668647897946 no 207 0.0580957897995754 113 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1423 4048-0112 5.59 µM 1.57083477796808 0.0593818242022025 no 208 0.0581105157705354 86 X1423
SGTC_897 1000-0139 31.4 µM 1.57027305236542 0.0594481433579727 no 209 0.0581758003046736 84 6151020
SGTC_3063 1327-0034 4 µM 1.5695311677278 0.0595358216377956 no 210 0.0582621114675151 80 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_809 3998-0021 90 µM 1.5597847787523 0.0606971154505275 no 211 0.0594053748245353 102 715485
SGTC_2571 chrysanthemic acid 100 µM 1.5554678823755 0.0612171071455951 no 212 0.0599173390104082 95 2743 An insecticide.
SGTC_1651 st011928 86.1 µM 1.55332916146059 0.0614760130085283 no 213 0.0601722584520805 90 720198
SGTC_1798 st045719 60.953 µM 1.55330341225183 0.06147913531743 no 214 0.0601753327286825 89 3980186
SGTC_1692 fluoroquinolonic acid 71 µM 1.5490040741952 0.0620022053886384 no 215 0.0606903703410295 72 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_68 0986-0284 82.829 µM 1.5430182102402 0.0627362385082729 no 216 0.0614131788112178 83 423278 YIL048W NEO1
SGTC_2342 7990637 118.86 µM 1.54212545828445 0.0628462926504208 no 217 0.0615215547782262 107 2033102 YER133W GLC7
SGTC_2356 9061756 188.97 µM 1.5407153133989 0.0630204348715438 no 218 0.061693044084686 81 20104043
SGTC_1608 st001473 40.5 µM 1.5399301150664 0.0631175637019413 no 219 0.0617886945737382 113 7292267
SGTC_677 0929-0063 136 µM 1.53685548061866 0.0634990175802145 no 220 0.0621643518014835 72 1539583
SGTC_1953 st076800 12.1 µM 1.53558505029534 0.0636571561025584 no 221 0.0623200915235545 112 297591
SGTC_1431 4049-0260 9.09 µM 1.53161164216542 0.0641537297058649 no 222 0.0628091489351798 100 3854841
SGTC_1813 st051246 8.6015 µM 1.53031972967586 0.0643158325406809 no 223 0.0629688035052058 82 5291959
SGTC_3264 9137442 49.47 µM 1.52604976129057 0.0648538725260446 no 224 0.0634987361299635 85 17015726
SGTC_849 0386-0493 241 µM 1.52388773442555 0.0651276294255427 no 225 0.0637683789806479 93 726119
SGTC_1852 st056254 31.4 µM 1.5228320517366 0.0652616259064546 no 226 0.0639003644428072 78 442583
SGTC_874 0599-0792 117 µM 1.51968344011368 0.0656625456995294 no 227 0.0642952777735261 113 765305
SGTC_2106 5357045 167.29 µM 1.51387306806371 0.0664074034507473 no 228 0.06502901799498 99 668842
SGTC_684 1140-0066 328 µM 1.50670357142695 0.0673354904756305 no 229 0.065943327858308 96 6813534
SGTC_980 1473-0395 201 µM 1.50654914226544 0.0673555909852805 no 230 0.0659631308984437 93 768876
SGTC_2206 7254556 146.969 µM 1.50416442035788 0.0676665756735878 no 231 0.0662695182153803 73 4398905
SGTC_760 0568-0725 82.9 µM 1.50208429906388 0.067938743031881 no 232 0.0665376696187355 90 3916171
SGTC_1640 st009078 66.4 µM 1.4978732257049 0.0684923155303567 no 233 0.0670830955939979 105 690618
SGTC_569 4130-2812 160 µM 1.49682905677373 0.0686301151135477 no 234 0.067218871784211 93 743552
SGTC_2537 larixol 68.93 µM 1.4962370472761 0.0687083378779365 no 235 0.0672959467534792 107 6708759
SGTC_380 3970-0968 6 µM 1.49550425095063 0.0688052581366811 no 236 0.0673914456596808 92 2891601
SGTC_1957 st077035 62.4 µM 1.49549243552802 0.0688068217174731 no 237 0.0673929863175269 92 705593
SGTC_761 k216-0224 480 µM 1.49103555504085 0.0693985745335361 no 238 0.0679760801743641 112 1340404
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.49059688142909 0.0694570297323516 no 239 0.0680336817909879 94 688751
SGTC_2485 5633444 17.78 µM 1.48758048472866 0.0698600052566272 no 240 0.0684307815883066 103 5724239
SGTC_2214 7179297 48.276 µM 1.48161957938087 0.0706616406396988 no 241 0.0692207731581452 75 769744
SGTC_3023 9089636 49.47 µM 1.48144511084989 0.070685209581704 no 242 0.0692440006555695 89 17249241
SGTC_2969 9091408 28.7 µM 1.48120246662018 0.0707179984171282 no 243 0.0692763145621371 96 4286311
SGTC_2698 st077697 67.5 µM 1.47900414860319 0.0710155928629332 no 244 0.0695696030178343 99 3154499
SGTC_2275 7947463 200 µM 1.47753305092156 0.071215277361435 no 245 0.0697664027592087 102 1225414
SGTC_1990 st072050 59.8 µM 1.47638198504063 0.0713718216360555 no 246 0.0699206880493747 94 17233948
SGTC_948 3448-0295 75.3 µM 1.47417372200414 0.0716728833244899 no 247 0.0702174115890423 105 678569
SGTC_2197 6588183 93.1375 µM 1.47290026029247 0.0718469420229596 no 248 0.0703889659418418 72 884136
SGTC_996 3970-0799 1.8 µM 1.47087356883422 0.0721246215725406 no 249 0.0706626559313533 128 6615648 YGL040C HEM2
SGTC_1706 st031321 9.9705 µM 1.46776758984282 0.0725517711094294 no 250 0.0710836819736708 99 6103185
SGTC_648 0375-0473 33.3 µM 1.4666507171761 0.072705841709877 no 251 0.0712355478856421 110 1713139
SGTC_963 1269-2853 151 µM 1.46150481716578 0.0734189477084954 no 252 0.0719384772690509 92 3668223
SGTC_2098 5376439 882.5 nM 1.45685512819224 0.0740678792525667 no 253 0.0725781872997183 88 2844116
SGTC_1192 1488-0095 21.4 µM 1.45681852036675 0.0740730057344809 no 254 0.0725832410809866 88 915875
SGTC_1084 voriconazole 435 nM 1.45459312887144 0.0743851541737057 no 255 0.0728909671822988 113 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2480 5767542 37.17 µM 1.45420211510603 0.0744401039922544 no 256 0.0729451393907363 91 2867358
SGTC_3266 9136860 49.47 µM 1.4513007365896 0.0748488081238292 no 257 0.0733480681447104 115 4871271 YPR165W RHO1
SGTC_1498 4478-3555 97.6 µM 1.45114505485172 0.0748707866068208 no 258 0.0733697364650763 67 3437919
SGTC_1107 amlodipine 47 µM 1.4493759666987 0.0751208848822794 no 259 0.0736163082976694 100 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1723 st034307 2.5525 µM 1.44881372312451 0.0752005032417853 no 260 0.0736948051643075 128 867466
SGTC_1963 st076565 50.3 µM 1.44809957101329 0.0753017258531804 no 261 0.073794602764961 116 4914280
SGTC_698 k064-0052 127 µM 1.44734347658952 0.0754090064482771 no 262 0.0739003740373677 106 5088751
SGTC_1947 st076332 61.6 µM 1.44652477154335 0.0755253020434398 no 263 0.0740150346072484 98 24208416
SGTC_395 anisomycin 6.25 µM 1.4452160416248 0.0757114885760669 no 264 0.0741986059436852 103 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1344 1488-0097 29.1 µM 1.44127461685241 0.076274327818307 no 265 0.0747535576985935 103 747966
SGTC_3257 9139206 32.98 µM 1.44071808630629 0.076354056795475 no 266 0.0748321715803851 101 4910041
SGTC_2216 7189485 200 µM 1.43843982377702 0.0766811036334223 no 267 0.0751546500256764 97 731273
SGTC_1262 0737-0114 49.6 µM 1.43718152691712 0.0768621894763499 no 268 0.0753332102892368 114 765919
SGTC_3238 9133470 49.47 µM 1.43396007484562 0.0773272812422018 no 269 0.0757918283050922 89 3534688
SGTC_1009 4106-0057 9.87 µM 1.43286316779349 0.0774861322928096 no 270 0.0759484724765283 127 2928005
SGTC_2381 9035592 200 µM 1.43030538217963 0.0778575062527522 no 271 0.0763146953724327 105 4749657
SGTC_1265 0819-1001 68.8 µM 1.42933287721134 0.0779990615895381 no 272 0.0764542903650783 110 3106768
SGTC_2224 6650123 117.647 µM 1.42535472699444 0.0785801446735931 no 273 0.077027343937354 99 2908370
SGTC_2041 5107442 45.335 µM 1.42291399914588 0.078938279152826 no 274 0.0773805437549705 131 793005
SGTC_1279 0874-0590 65.2 µM 1.42024467262394 0.0793313705556125 no 275 0.0777682311555852 93 3523074
SGTC_347 4534-1311 26.2 µM 1.41170132009249 0.0805994471944616 no 276 0.0790189622536201 105 2862016
SGTC_2926 9010726 65.15 µM 1.40758123369762 0.0812164304049762 no 277 0.07962755377861 105 2994293
SGTC_1277 0873-0036 22 µM 1.40177793470172 0.082091510341607 no 278 0.080490784749481 106 5965735
SGTC_1880 MG-132 525 µM 1.40052094558064 0.0822819842945269 no 279 0.0806786878124377 122 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1331 1472-0049 76.2 µM 1.39450231170938 0.0831986137154447 no 280 0.081582985955246 126 24051409
SGTC_2372 9071633 200 µM 1.39378637511983 0.0833081588231099 no 281 0.0816910618665606 105 21321366
SGTC_1857 st056007 79.3 µM 1.39149906707309 0.0836588653065925 no 282 0.0820370711747273 81 619834
SGTC_75 0159-0059 199.013 µM 1.38966459001016 0.0839409411321466 no 283 0.082315376117045 129 5377270
SGTC_960 1222-0186 7.7 µM 1.38769151633367 0.0842451246095847 no 284 0.0826155002295369 113 3126296
SGTC_455 paf C-16 10 µM 1.38524666595029 0.0846231874065107 no 285 0.0829885279122555 107 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_940 3232-1287 54.8 µM 1.38500313853256 0.0846609151827881 no 286 0.0830257538402033 104 1585493 YIL048W NEO1
SGTC_1414 3917-0015 5.4 µM 1.38351383960632 0.0848919150019284 no 287 0.0832536833783767 100 6618702
SGTC_2437 5741531 144.16 µM 1.38213857799772 0.0851056462428705 no 288 0.0834645775875902 131 2262990
SGTC_678 1218-2179 85.9 µM 1.37673663204889 0.0859490737162547 no 289 0.0842968443688695 110 6820081 YOR116C RPO31
SGTC_2987 9018338 71.43 µM 1.37534906440677 0.086166726538806 no 290 0.0845116260711109 138 5055682
SGTC_309 k408-0051 1.48 µM 1.36879431175888 0.0872004767394321 no 291 0.0855317897355862 152 3640463
SGTC_1429 4049-0205 9.46 µM 1.3673504423492 0.0874294289575875 no 292 0.0857577439543552 100 22774478
SGTC_300 r073-0011 5.04 µM 1.36327100644377 0.0880787234081109 no 293 0.0863985580408884 113 2735780
SGTC_1082 camptothecin 424.86 nM 1.36206695134044 0.0882710496326885 no 294 0.0865883784741599 141 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_709 3807-1509 243 µM 1.3536934908394 0.0896172248423258 no 295 0.0879170928295503 140 1886677 YPL242C IQG1
SGTC_209 4077-0173 175.592 µM 1.35072806569471 0.0900976092082301 no 296 0.0883912792160318 105 15993494
SGTC_1648 st011736 69.8 µM 1.34599719262596 0.0908679440478534 no 297 0.0891517109822582 109 2855514
SGTC_99 0109-0120 622.8 µM 1.34402792983817 0.0911900384296171 no 298 0.0894696777059693 100 759414
SGTC_2838 9002687 71.43 µM 1.34247324666265 0.0914449212326286 no 299 0.0897212995985784 144 6457060
SGTC_3211 9128781 49.47 µM 1.3416193897504 0.0915851314056027 no 300 0.0898597179955876 127 17194361
SGTC_759 3486-0358 89.3 µM 1.34108818035073 0.0916724406089073 no 301 0.089945912186193 135 875103
SGTC_536 3852-0578 10.6 µM 1.33859623225557 0.0920828387451017 no 302 0.0903510766850856 135 2869208
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.33800419387441 0.0921805410314139 no 303 0.0904475348330126 97 364106
SGTC_2563 tomatine 8.54 µM 1.33761332575457 0.0922450868465342 no 304 0.0905112591063167 120 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1222 0366-0074 1.18 µM 1.33171165957246 0.0932237248830639 no 305 0.0914774781963637 133 286520
SGTC_2273 7815444 169.05 µM 1.33085378891682 0.0933666167226228 no 306 0.0916185625524597 134 2824616
SGTC_890 0929-0006 47.2 µM 1.33047276848535 0.0934301335280629 no 307 0.0916812763882882 111 1378169
SGTC_472 calcifediol 10 µM 1.32588602923676 0.0941972576491988 no 308 0.092438725628883 100 5283731 A vitamin D metabolite.
SGTC_616 4092-0450 108 µM 1.3224571499252 0.0947737595322996 no 309 0.0930079845588156 119 787165
SGTC_2457 5731572 11.68 µM 1.31941167295222 0.0952879760742098 no 310 0.0935157607105346 134 2865357
SGTC_1839 st053978 48 µM 1.31494928711358 0.0960451376979291 no 311 0.0942634733344216 111 3788398
SGTC_3156 9099931 49.47 µM 1.31487000869871 0.0960586292548908 no 312 0.0942767968914247 115 18111053
SGTC_3331 9141060 1.957 µM 1.3117487264208 0.0965909153518271 no 313 0.0948024650815448 106 4906567 YPR165W RHO1
SGTC_1028 k015-0029 4.8 µM 1.31101723997009 0.0967159717750621 no 314 0.0949259695721049 131 4588309
SGTC_1888 azatryptophan 97.5 µM 1.30464724013753 0.0978100298858569 no 315 0.0960064972658703 96 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_753 1322-0200 289 µM 1.30391899451909 0.0979356828515158 no 316 0.0961306016025288 108 5403907
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.29605012031296 0.099300946157589 no 317 0.0974791089679497 124 15053
SGTC_2929 9013348 24.6 µM 1.2909429417268 0.100194465803503 no 318 0.0983617317910241 109 2995952
SGTC_2731 amoxapine 43.43 µM 1.2899203822853 0.100374069341278 no 319 0.0985391515737299 122 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_898 1000-0849 28.3 µM 1.2873407195084 0.100828208073717 no 320 0.0989877783300465 153 6751807
SGTC_3313 9133968 57.047 µM 1.286960365942 0.100895294251695 no 321 0.099054051455603 115 1494643
SGTC_1985 st071382 65.5 µM 1.28480789613522 0.101275556841092 no 322 0.0994297112016166 144 6123237
SGTC_636 0kpi-0074 126 µM 1.28213872420803 0.101748550712444 no 323 0.099896993399669 127 616434
SGTC_460 trequinsin 123 µM 1.2786138607262 0.102375639851365 no 324 0.100516533270423 134 5537 A vasodilator.
SGTC_2371 9071574 200 µM 1.2781753365996 0.102453851425428 no 325 0.100593805136211 131 45596039
SGTC_475 α-linolenic acid 10 µM 1.27781319081139 0.102518473530854 no 326 0.100657651118855 137 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2272 7805186 180 µM 1.2771507392379 0.102636759545452 no 327 0.100774517220777 136 2956062 YPR165W RHO1
SGTC_1055 3448-0672 86 µM 1.27416803873604 0.103170573467435 no 328 0.101301934817706 134 748378
SGTC_2134 5324836 1.464 µM 1.2705645862622 0.103818169054831 no 329 0.101941796140953 116 699272
SGTC_2100 5377183 190 µM 1.26919986531805 0.104064198524657 no 330 0.102184894548538 135 2844202
SGTC_2705 st078069 42.8 µM 1.26809487729149 0.104263713302604 no 331 0.102382035349598 122 1530061
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.26473620167694 0.104871851896819 no 332 0.102982954021569 148 165506
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.26458570778402 0.104899161062586 no 333 0.10300993953836 132 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1840 st055363 71 µM 1.26269433439474 0.105242815562746 no 334 0.103349525463936 119 676033
SGTC_3145 9085516 49.47 µM 1.2621264665854 0.105346153556668 no 335 0.103451641535902 127 25236195
SGTC_689 0833-0039 98 µM 1.25922291752699 0.105875675443746 no 336 0.103974913017769 131 5374726
SGTC_2553 4-methylesculetin 85.09 µM 1.2587711660654 0.105958234244101 no 337 0.104056498951064 123 5319502
SGTC_2079 5212404 121 µM 1.25632659390864 0.106405793482199 no 338 0.104498791889138 112 758462
SGTC_1464 k208-0027 110 µM 1.25597176407337 0.106470870020585 no 339 0.104563103772615 139 X1464
SGTC_1391 3442-0225 151 µM 1.25564211665013 0.106531353795873 no 340 0.10462287710427 116 5227075
SGTC_1632 st005650 90 µM 1.25267760106548 0.107076398525818 no 341 0.105161530396342 128 2759605
SGTC_260 nsc-65238 3.989 µM 1.25138346046125 0.107314963947862 no 342 0.105397304323272 130 3246252
SGTC_1139 k015-0024 46.9 µM 1.24916562021031 0.107724697300456 no 343 0.105802251856249 126 2766652
SGTC_990 3985-0011 41.3 µM 1.24872376454908 0.107806462068124 no 344 0.105883062874401 132 5399565 YGL099W LSG1
SGTC_2607 solasodine 47.35 µM 1.24579509218391 0.10834953899996 no 345 0.106419815917472 163 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2962 9082311 13.18 µM 1.24572510327025 0.108362541402018 no 346 0.106432667143399 147 16459453
SGTC_515 4092-1064 102 µM 1.24471855870151 0.10854965946261 no 347 0.106617610816846 155 717353
SGTC_1290 0986-0249 10.2 µM 1.24331023164306 0.108811859408554 no 348 0.106876767646908 129 53329
SGTC_3268 9137683 49.47 µM 1.2417079377426 0.109110725195152 no 349 0.107172170102097 158 1953228
SGTC_220 paclitaxel 373.376 µM 1.240572319762 0.10932290177561 no 350 0.107381891368091 117 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2145 5634607 200 µM 1.24051985139535 0.109332712018305 no 351 0.107391588155344 111 308662
SGTC_2884 9058502 51.95 µM 1.23855342290228 0.10970083995762 no 352 0.107755463098003 125 6471554
SGTC_2242 6630449 61.2675 µM 1.23819238682598 0.109768524781696 no 353 0.107822366888965 121 691249 YDR170C SEC7
SGTC_647 0140-0236 81 µM 1.23769321560576 0.109862155700119 no 354 0.107914917852172 129 990837
SGTC_1873 rapamycin 2 nM 1.23711525382654 0.109970637167701 no 355 0.108022148767327 124 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1995 st072814 61.1 µM 1.23302415237895 0.110740721132511 no 356 0.108783376648602 127 5769371
SGTC_1476 4112-3294 3.34 µM 1.23275901659469 0.110790761672342 no 357 0.108832843002882 139 704369
SGTC_3294 9122953 26.2835 µM 1.23266834081213 0.110807879130611 no 358 0.108849764084469 124 16459826
SGTC_2721 ifenprodil 61.44 µM 1.23157875337279 0.111013715852055 no 359 0.109053240821159 134 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1490 4089-0339 670 nM 1.23135235260105 0.111056520136782 no 360 0.109095554673836 142 742542
SGTC_2681 menadione 3.18 µM 1.22617693242603 0.112038232088399 no 361 0.110066049984337 144 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_363 0455-0021 3.06 µM 1.22546018743968 0.112174677171049 no 362 0.110200940845599 154 4597466
SGTC_387 norethindrone acetate 66.7 µM 1.22283038055366 0.112676324664172 no 363 0.11069688407702 136 541197
SGTC_3092 9117248 49.47 µM 1.21958409931444 0.113297774150575 no 364 0.111311288577749 153 17141857
SGTC_909 3448-9333 149 µM 1.21888334506834 0.11343224277272 no 365 0.11144423594188 132 3344074
SGTC_3120 9124077 49.47 µM 1.21715602307399 0.113764186734273 no 366 0.111772429338843 145 18774327 YGL155W CDC43
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.21396856098061 0.114378546024958 no 367 0.112379864915658 154 688798
SGTC_2529 gangaleoidin 93.61 µM 1.21352001182259 0.114465189724162 no 368 0.112465534011784 135 4565183
SGTC_3054 9094397 49.47 µM 1.21331290267908 0.114505211586883 no 369 0.112505105847103 149 2598354
SGTC_398 bronopol 33.3 µM 1.21242948645769 0.114676035181965 no 370 0.112674009706924 158 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_171 k064-0041 9.68 µM 1.20484117580593 0.116150836263672 no 371 0.114132310447611 135 53325
SGTC_1387 3342-1166 1.8 µM 1.20361636338349 0.116390136717956 no 372 0.114368945955735 120 3418228
SGTC_1030 k029-0042 36.7 µM 1.20229328699923 0.11664902845515 no 373 0.114624958448148 136 6080581
SGTC_1975 st070967 30.8 µM 1.20064210131849 0.116972695116261 no 374 0.114945031133057 189 261391
SGTC_1575 cyproterone acetate 48 µM 1.19963655782322 0.117170114045522 no 375 0.115140261014962 154 9880 An androgen receptor antagonist and liver toxin.
SGTC_331 k048-0133 24.5 µM 1.1986545831265 0.117363133394906 no 376 0.115331142354444 140 6813582
SGTC_3293 9120939 62.045 µM 1.19786260913531 0.117518969699681 no 377 0.115485254136783 131 934087
SGTC_543 3844-1095 191 µM 1.19317235948017 0.118444870670553 no 378 0.116400938683466 181 4230703
SGTC_3275 9138069 49.47 µM 1.18745395782278 0.119580699096868 no 379 0.117524303703153 151 17617007
SGTC_3109 9122853 49.47 µM 1.18698733534632 0.119673720774785 no 380 0.117616308026406 170 1234709
SGTC_3274 9138298 49.47 µM 1.18603926283232 0.119862877173915 no 381 0.117803397237638 159 17015756
SGTC_2692 st077426 47.7 µM 1.18408285788317 0.120253878886347 no 382 0.118190132557594 145 25238571
SGTC_332 4112-0506 40.9 µM 1.18355940522155 0.120358646905507 no 383 0.1182937589277 172 2790355
SGTC_107 0358-0022 2.6945 µM 1.18278281001159 0.120514199332311 no 384 0.11844761749576 134 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_422 cantharidin 155 µM 1.18243734649851 0.120583441330891 no 385 0.118516105951497 144 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_950 1165-0508 94.1 µM 1.18015761222892 0.121041075773084 no 386 0.118968767110301 139 6148369
SGTC_1014 4130-3005 69.3 µM 1.18008865549831 0.121054937177808 no 387 0.118982478068431 143 743608
SGTC_2732 terfenadine 20 µM 1.17966383406686 0.12114035770649 no 388 0.119066971720878 159 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1142 3253-1408 9.78 µM 1.1790339270211 0.121267093638691 no 389 0.119192333256082 148 256655
SGTC_3121 9125696 49.47 µM 1.17861429365706 0.121351574694028 no 390 0.119275898669163 127 1235365
SGTC_338 4055-0136 114 µM 1.17846280554517 0.121382082612829 no 391 0.119306076031845 124 2900563
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.17746559282567 0.121583044080916 no 392 0.119504861414248 131 61125 An anti-inflammatory.
SGTC_2787 5284540 71.43 µM 1.17628995199411 0.121820263157984 no 393 0.119739514809094 145 736958
SGTC_669 0108-0021 26.2 µM 1.17612787185172 0.121852992937715 no 394 0.119771890850421 136 17201
SGTC_1591 genipin 88.4 µM 1.17435163923612 0.122212082697283 no 395 0.120127103693444 152 442424 A DNA cross-linking agent.
SGTC_1881 5652484 16 µM 1.17266140991163 0.122554474930347 no 396 0.120465806221487 129 2255129
SGTC_2821 7996764 71.43 µM 1.17241274773096 0.122604903527897 no 397 0.120515691958891 133 2987135
SGTC_640 3381-0960 37.1 µM 1.17109058530744 0.122873282053888 no 398 0.120781183872978 152 1745025
SGTC_1352 1496-0991 99 µM 1.16933833000182 0.123229597141261 no 399 0.121133672923305 160 3000039
SGTC_2931 9014674 55.67 µM 1.16649933777836 0.123808432198915 no 400 0.121706308089121 145 2996810
SGTC_2222 6885208 172.143 µM 1.16638983402794 0.123830796705004 no 401 0.121728433434034 135 609514
SGTC_1704 st028805 70.8 µM 1.16352202726395 0.124417510458692 no 402 0.122308883194362 158 2876101
SGTC_2317 5986382 200 µM 1.16222619665173 0.124683256156405 no 403 0.122571798134736 162 877883
SGTC_2797 7859098 81.82 µM 1.16191401325177 0.124747337202878 no 404 0.12263519718234 154 972681
SGTC_3038 9091290 49.47 µM 1.1606645979813 0.125004031685052 no 405 0.122889162065204 135 25236843
SGTC_539 4859-0462 2.54 µM 1.15671681451187 0.125817534292424 no 406 0.123694038820181 156 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2889 9059656 51.95 µM 1.15595505895533 0.125974929996772 no 407 0.123849769917993 150 3949838
SGTC_1879 gemcitabine 100 µM 1.15568689403696 0.126030371515964 no 408 0.123904625423811 144 60750 A nucleoside analog which inhibits DNA replication.
SGTC_259 usnic acid 108.925 µM 1.15510626235434 0.126150471988623 no 409 0.124023457035587 173 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1682 st012968 530 nM 1.15409318253711 0.126360212968153 no 410 0.124230984048844 130 24207270
SGTC_2132 5317594 122.667 µM 1.15398680811781 0.126382250074349 no 411 0.124252788681173 157 794577
SGTC_2871 9038510 12.99 µM 1.15382282953863 0.126416226018674 no 412 0.12428640625989 188 4945164
SGTC_736 0958-0254 92.6 µM 1.15205401669248 0.12678312412677 no 413 0.124649438591512 154 6812352
SGTC_495 decylubiquinone 155 µM 1.15105298997669 0.126991091499284 no 414 0.124855218092702 146 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1303 1160-0052 261 µM 1.14937368839156 0.127340506258351 no 415 0.125200962365126 131 3562476
SGTC_2152 5568786 200 µM 1.14611583350086 0.12802027866877 no 416 0.125873613510543 160 5399883
SGTC_3101 9120531 49.47 µM 1.14587794929417 0.128070013312689 no 417 0.125922828146535 158 24824904
SGTC_1022 4477-0945 21.3 µM 1.14373173185484 0.128519331545195 no 418 0.126367454691953 136 4648966
SGTC_681 1642-0006 26.6 µM 1.14311116690135 0.128649452689638 no 419 0.126496219229315 171 4446530
SGTC_2280 7785178 200 µM 1.14305805908894 0.128660592673582 no 420 0.126507243114447 141 2954328
SGTC_2656 pseudo-anisatin 100 µM 1.13982952942202 0.129339071969469 no 421 0.127178664362695 161 6708809 A neurotoxin.
SGTC_2484 5809818 12.04 µM 1.13978669528572 0.12934809024936 no 422 0.127187588998869 147 2870548
SGTC_1380 2291-0730 164 µM 1.13539311759959 0.130275427646292 no 423 0.128105321029679 148 2999191
SGTC_1725 st036284 20.55 µM 1.13250423415174 0.130887675068175 no 424 0.128711252638312 147 707914
SGTC_2654 protoveratrine a 100 µM 1.13102630732295 0.131201663005355 no 425 0.129022009487729 163 5702278 A heart drug and vasodilator.
SGTC_2450 5739737 12.93 µM 1.13101027535698 0.131205071872208 no 426 0.129025383305191 150 2262825
SGTC_3036 9090181 49.47 µM 1.13097118824063 0.131213383197579 no 427 0.12903360917758 156 25236586
SGTC_1554 st069299 38.7 µM 1.12905505230684 0.131621268441136 no 428 0.129437305365854 135 24207999
SGTC_2355 9061122 103.12 µM 1.12618651740936 0.132233523658168 no 429 0.130043289577533 167 5302957
SGTC_1308 1187-1617 41.4 µM 1.12322849843039 0.132866931393822 no 430 0.130670231014064 156 2882570
SGTC_1253 0550-0034 176 µM 1.12174732364709 0.133184882633202 no 431 0.130984944532501 159 5969915
SGTC_2166 5933061 31.504 µM 1.12031799557 0.13349220043173 no 432 0.131289138063313 143 2877375
SGTC_2795 7780010 54.55 µM 1.11971711786202 0.13362153979298 no 433 0.131417164046872 160 953673
SGTC_2673 kobusone 100 µM 1.11908604225021 0.133757472019881 no 434 0.13155171691672 177 6710676 An epoxy ketone and protein crosslinker.
SGTC_741 4582-0002 126 µM 1.11860239377219 0.133861713105811 no 435 0.131654900899452 177 2912688
SGTC_2104 5389443 200 µM 1.11709082809546 0.134187861768672 no 436 0.131977745867336 154 2244536
SGTC_3165 9101544 49.47 µM 1.11539142517582 0.134555191149437 no 437 0.132341361230599 162 5002184
SGTC_691 1548-0686 185 µM 1.11293135135125 0.135088162901396 no 438 0.132868956981183 187 46495133
SGTC_2690 usnic acid 100 µM 1.11238335005198 0.135207083550896 no 439 0.132986680161344 148 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2713 st079149 53.4 µM 1.11214846648688 0.135258077124838 no 440 0.133037160486812 156 3103253
SGTC_3203 9113543 49.47 µM 1.1119215415986 0.13530735537852 no 441 0.133085942887992 161 17018012
SGTC_2047 4141938 200 µM 1.1103845752457 0.135641441819087 no 442 0.133416671052321 173 3807862
SGTC_2885 9057732 51.95 µM 1.10907439169532 0.135926678881073 no 443 0.133699045562825 185 6471414
SGTC_1198 1612-1005 86.7 µM 1.10826765460533 0.13610251591803 no 444 0.133873120100084 182 6998509
SGTC_430 0958-0115 16.4 µM 1.10696150431756 0.136387535413088 no 445 0.134155286179781 152 6833180
SGTC_3077 9117319 49.47 µM 1.10544659535854 0.136718619946891 no 446 0.134483061512124 167 17154678
SGTC_2887 9044784 58.44 µM 1.10416519895257 0.136999098761147 no 447 0.134760741450916 186 6465546
SGTC_2514 salinomycin 42.74 µM 1.10250633496986 0.137362783290284 no 448 0.135120802962981 165 23682228 A polyether potassium ionophore.
SGTC_2326 6164455 177.58 µM 1.10169557565114 0.137540771447853 no 449 0.135297020538115 172 2888790
SGTC_2458 5808907 16.39 µM 1.09788342825602 0.138379772293247 no 450 0.136127697553495 178 2731747
SGTC_1905 st060207 84.5 µM 1.09509776563611 0.13899505945541 no 451 0.136736903733987 177 1948547
SGTC_1507 4075-3230 155 µM 1.09376482319905 0.139290132841766 no 452 0.137029067850894 152 659771
SGTC_2917 7979103 53.79 µM 1.09345357848653 0.139359094401432 no 453 0.137097350137448 141 2980565
SGTC_50 0929-0078 56.389 µM 1.09309647400567 0.139438245582322 no 454 0.137175721981335 152 1377751
SGTC_521 r062-0005 13.8 µM 1.09282520963319 0.13949839098358 no 455 0.137235275397236 142 2832033
SGTC_1596 piperlongumine 63 µM 1.09217752886352 0.13964206770397 no 456 0.137377538728369 144 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1933 st074711 15.9 µM 1.08968952815565 0.140194922869574 no 457 0.137924965264661 179 17250958
SGTC_2417 cerulenin 830 nM 1.08955012210626 0.140225944019495 no 458 0.13795568227791 153 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2164 5685496 200 µM 1.08910030259438 0.140326071312556 no 459 0.138054828244753 131 759046
SGTC_2568 diosmetin 100 µM 1.08897557768142 0.140353842972185 no 460 0.138082327811925 191 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1376 2910-0861 41.3 µM 1.08896894237965 0.140355320514867 no 461 0.138083790879518 174 1112859
SGTC_3307 9126885 69.2785 µM 1.08661938295089 0.140879182318334 no 462 0.138602527641024 146 24824909
SGTC_2982 9019404 25.97 µM 1.08487998390515 0.141267855141254 no 463 0.138987407125656 137 22333232
SGTC_2090 5301565 104.445 µM 1.08273536354229 0.141748075433197 no 464 0.139462951306485 169 2056344
SGTC_3172 9105863 49.47 µM 1.08157755309243 0.142007789725973 no 465 0.139720141569352 157 2348785
SGTC_3170 9103054 49.47 µM 1.07771112180556 0.142877421390793 no 466 0.140581346796225 162 16432970
SGTC_970 1315-0089 19.5 µM 1.07732855969273 0.142963661927127 no 467 0.140666753789913 151 6811083 YLR033W RSC58
SGTC_1360 1598-0022 39.8 µM 1.07497942345032 0.143493996091051 no 468 0.141191970405972 180 761525
SGTC_3108 9121785 49.47 µM 1.070880299643 0.14442257938173 no 469 0.142111627478276 172 17140271
SGTC_3089 9117425 49.47 µM 1.06948392860942 0.144739824943146 no 470 0.142425833418428 149 9401657
SGTC_2202 7226349 200 µM 1.06427464270448 0.145927476666049 no 471 0.143602150807805 148 844334
SGTC_1372 2752-0194 270 µM 1.06315380720931 0.146183866728861 no 472 0.143856103287451 149 823334
SGTC_148 3253-0744 288.01 µM 1.0609130665816 0.146697340589639 no 473 0.144364705249427 172 6893655
SGTC_1215 3852-0577 11.2 µM 1.05969057585442 0.14697798841229 no 474 0.144642695803424 159 2884876
SGTC_1569 carminic acid 40.6 µM 1.05899228783005 0.147138456224021 no 475 0.144801646011224 158 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3052 9092717 49.47 µM 1.05779823608972 0.147413123458059 no 476 0.14507371858207 171 25237534
SGTC_981 1488-1094 54.9 µM 1.05384047680829 0.148325980576792 no 477 0.145977979180132 171 3449522
SGTC_853 0419-0306 21 µM 1.05240428734046 0.148658170718468 no 478 0.146307051249514 197 762713
SGTC_3278 9139605 49.47 µM 1.0514577977029 0.148877365130289 no 479 0.146524191190296 177 7958859
SGTC_2680 butyl paraben 22.24 µM 1.05139978747141 0.148890806548647 no 480 0.146537506701531 196 7184 An antifungal and steroid mimetic.
SGTC_2031 5180455 200 µM 1.05073445965722 0.149045026120576 no 481 0.146690282319 173 29949
SGTC_2735 sertaconazole 140 nM 1.05069306459236 0.149054624808841 no 482 0.146699791173615 188 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2874 9043904 71.43 µM 1.05050800024567 0.14909754258189 no 483 0.146742307336727 174 4463428
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.04765178565328 0.149760966292539 no 484 0.147399534454639 168 5377381
SGTC_1461 k072-0203 53.8 µM 1.04545572953972 0.150272389597883 no 485 0.147906195614846 161 5418714
SGTC_1816 st051957 91.6 µM 1.04298116652738 0.150850065416054 no 486 0.148478507733758 164 674121
SGTC_1780 st038448 24.544 µM 1.04203509253117 0.151071312333808 no 487 0.148697704687113 170 728868 YDL195W SEC31
SGTC_52 0329-0193 875 nM 1.04144004140344 0.151210580324553 no 488 0.148835683510498 177 3739292
SGTC_244 nsc-207895 1.295 µM 1.04102450994905 0.151307883488102 no 489 0.148932086523408 130 42640
SGTC_1927 st060202 13.8 µM 1.0390881377765 0.151761864299724 no 490 0.149381873636321 173 688887
SGTC_2165 5727197 32.143 µM 1.0386978247942 0.151853482347926 no 491 0.149472646564196 181 1361712
SGTC_1661 st013063 9.66 µM 1.03863583902207 0.151868035630142 no 492 0.149487065638723 182 721395
SGTC_317 4495-0002 170 µM 1.03844260849579 0.151913409058526 no 493 0.149532020707532 152 15991618
SGTC_32 0928-0142 34.1 µM 1.03711994808843 0.1522242313587 no 494 0.14983997979123 178 2244242
SGTC_1796 st049173 110.4 µM 1.03486473514409 0.152755174539174 no 495 0.150366042853572 171 94134
SGTC_1546 5-methoxyflavanone 78.7 µM 1.03434522291332 0.152877656786626 no 496 0.150487401246152 157 147795
SGTC_2334 9017922 200 µM 1.03310946866237 0.153169264688887 no 497 0.150776336362096 160 3163164
SGTC_318 1488-0629 67.2 µM 1.03244296344666 0.153326696611183 no 498 0.150932327013244 166 3662576
SGTC_357 1325-0123 420 µM 1.03147828265466 0.15355474892946 no 499 0.15115829365074 184 1098503
SGTC_715 0868-0130 184 µM 1.03067296487567 0.153745299479983 no 500 0.151347103411925 155 2876258
SGTC_3220 9131269 49.47 µM 1.02784271549826 0.154416221206412 no 501 0.152011909726398 177 17722206
SGTC_714 4296-0578 26.1 µM 1.02450148136435 0.155210761604756 no 502 0.152799235748955 188 1589775
SGTC_1032 k061-1018 98.7 µM 1.02251394414479 0.155684672805283 no 503 0.153268858177704 163 4005393
SGTC_2095 5432005 200 µM 1.02143124510318 0.155943234201462 no 504 0.153525084158356 180 783734
SGTC_374 0880-0231 82.3 µM 1.0210364279074 0.156037591629135 no 505 0.153618590106889 193 6833587
SGTC_1173 0443-0020 122 µM 1.01974780541917 0.156345821499885 no 506 0.153924041457869 182 5331295
SGTC_3061 glucosamine 200 µM 1.01776660013798 0.156820494265605 no 507 0.154394444103245 155 91431 and experimental redox chemotherapeutic
SGTC_2144 5628481 200 µM 1.0172396110406 0.156946913969112 no 508 0.154519728339066 157 2818399
SGTC_1797 st048695 56.8 µM 1.0149303051559 0.157501685036898 no 509 0.155069525509134 197 592262 YIL048W NEO1
SGTC_711 k292-0785 179 µM 1.01336939949298 0.157877394828498 no 510 0.155441875032892 191 4146315
SGTC_471 1-acyl-paf 4 µM 1.0122577436632 0.158145328779126 no 511 0.155707416688693 164 16759367
SGTC_1268 0828-0275 2.46 µM 1.01224454219227 0.158148512421346 no 512 0.155710571925454 186 745337
SGTC_510 ag-490 170 µM 1.01204084740015 0.158197640410983 no 513 0.155759261639927 172 5328779
SGTC_2877 9040724 71.43 µM 1.01203495963822 0.158199060595751 no 514 0.155760669156783 158 6463895
SGTC_1856 st057054 55.7 µM 1.01035761261005 0.158603993547092 no 515 0.156161993998805 199 1266018
SGTC_2323 6148992 148.28 µM 1.00908420538926 0.158911863741301 no 516 0.156467126084016 166 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.00889848161151 0.158956798668735 no 517 0.15651166174351 155 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_369 0957-0393 4.5 µM 1.00798586594958 0.159177722372178 no 518 0.156730623806987 178 6997992
SGTC_1934 st074720 32.6 µM 1.00723533923931 0.159359558627538 no 519 0.156910847198313 170 17250992
SGTC_1015 4130-4525 82 µM 1.0060628825053 0.159643891413793 no 520 0.157192661077557 185 1363237
SGTC_288 1315-0019 35.1 µM 1.00394363100536 0.160158673494252 no 521 0.157702892266618 208 6811474
SGTC_3288 9119690 36.221 µM 1.00339946207577 0.160291031111362 no 522 0.157834081775589 196 17595618 YKL019W RAM2
SGTC_2757 clomiphene 4.22 µM 1.00280966819953 0.160434566743057 no 523 0.157976351567232 210 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2440 5628896 157.78 µM 1.00135486630522 0.160788974646824 no 524 0.158327638038207 181 5522048
SGTC_1883 5-benzylidenerhodanine 20 µM 0.999782084961697 0.161172698423138 no 525 0.158707988736386 186 1273210
SGTC_1433 4060-0023 7.6 µM 0.999336709544399 0.16128146861208 no 526 0.158815804031583 193 3840627
SGTC_1925 st057770 10.1 µM 0.997770925162277 0.161664246581792 no 527 0.159195225933449 177 5989122
SGTC_1389 3405-0187 19 µM 0.99743128832358 0.161747353661964 no 528 0.15927760525126 182 799890
SGTC_400 oxethazaine 37.5 µM 0.997255003834497 0.161790500384268 no 529 0.159320374266463 178 4621 A local anesthetic.
SGTC_1348 1493-0373 93.8 µM 0.997030375014489 0.161845490547811 no 530 0.159374883169476 202 3010129
SGTC_393 acivicin 6.25 µM 0.996500250368612 0.161975315765875 no 531 0.159503572741031 181 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2677 mitomycin C 100 µM 0.995370813175588 0.16225213617569 no 532 0.159777974252198 197 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2964 9083345 53.42 µM 0.993390454105494 0.162738257084637 no 533 0.160259855880022 199 17741579
SGTC_3197 9113331 49.47 µM 0.992378794088888 0.162986955568033 no 534 0.160506389745473 173 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1278 0874-0585 172 µM 0.991683267504045 0.163158081564428 no 535 0.16067602794281 182 766306
SGTC_1696 st025591 34.7925 µM 0.989594407418445 0.163672722254481 no 536 0.161186202324849 167 2787147
SGTC_1111 tnp00062 510.699 nM 0.986821422536672 0.164357539761624 no 537 0.161865095379755 178 676306
SGTC_2037 5169046 200 µM 0.986539688720199 0.164427220670377 no 538 0.161934174665883 182 5718022
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.986178245913858 0.164516643953366 no 539 0.162022826194661 220 368090
SGTC_2762 leflunomide 42.06 µM 0.981060514067828 0.165786185628476 no 540 0.163281450409041 213 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3107 9121808 49.47 µM 0.979700270209849 0.166124680150691 no 541 0.163617046349164 167 662681
SGTC_2925 9010536 32.5 µM 0.979393708133308 0.166201029245575 no 542 0.163692742369162 166 2994177
SGTC_1125 tnp00248 1.32998 µM 0.979229776036134 0.166241865731817 no 543 0.163733229656143 206 24207736
SGTC_999 SEC7.066 22.7 µM 0.978472917739057 0.166430487776022 no 544 0.163920239738535 205 740511 YDR170C SEC7
SGTC_448 monastrol 171 µM 0.977965305183439 0.166557070897334 no 545 0.164045741980429 205 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1512 0259-0544 12.2 µM 0.977101150972936 0.166772707562648 no 546 0.164259539008219 187 18476
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.976983374337433 0.166802110889278 no 547 0.164288691651476 201 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3102 9121669 49.47 µM 0.974514397286567 0.167419269027689 no 548 0.16490059705731 204 41905072
SGTC_2942 9052777 62.25 µM 0.973512241383113 0.167670192326103 no 549 0.165149389591549 225 6469503
SGTC_3104 9120930 49.47 µM 0.973220086060718 0.167743388770396 no 550 0.165221965005171 195 17014836
SGTC_2521 angolensin 13.4 µM 0.969986634714376 0.168554869762652 no 551 0.166026577083883 179 821428 A flavenoid.
SGTC_2297 7971671 152.32 µM 0.969280744724059 0.168732358039173 no 552 0.166202566898823 187 909016
SGTC_1182 1222-0449 220 µM 0.968536272737691 0.168919677420302 no 553 0.166388306340463 190 658318
SGTC_1515 3460-0031 42.1 µM 0.968174398808521 0.169010778104794 no 554 0.166478639203639 188 2876596
SGTC_1945 st075991 56.6 µM 0.964109251909032 0.170036334471655 no 555 0.167495577341939 175 1084980
SGTC_2764 methyldopa 94.69 µM 0.96142587501334 0.170715478322713 no 556 0.168169039677118 186 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2059 5238311 157 µM 0.961199092557223 0.170772954831231 no 557 0.168226036289591 197 703021
SGTC_1889 st059080 5.18 µM 0.961134600615141 0.170789302147456 no 558 0.168242247141686 168 176925 Isolated from Daphnopsis sellowiana.
SGTC_548 1436-0017 110 µM 0.95971705466377 0.171148872374997 no 559 0.168598818729622 183 9677137
SGTC_2069 5228469 200 µM 0.956935255881153 0.17185590072982 no 560 0.169299967417012 201 2835210
SGTC_1555 citronellol 128 µM 0.955485938455075 0.172225000523251 no 561 0.169666006492077 189 8842 A terpine precursor.
SGTC_2603 homopterocarpin 100 µM 0.954481449601154 0.172481111732633 no 562 0.169919997438712 183 101795 A weak amylase inhibitor.
SGTC_2024 5144227 134 µM 0.953861329086458 0.172639343014588 no 563 0.170076920210193 180 3475211
SGTC_2001 4023502 57.655 µM 0.951146765117285 0.173333085814379 no 564 0.170764938951096 172 108941 YCR052W RSC6
SGTC_447 ml7 120 µM 0.950566702414403 0.173481558362412 no 565 0.170912189184482 202 4216 Selective myosin light chain kinase inhibitor.
SGTC_2675 theaflavin digallate 100 µM 0.948800529218796 0.173934125393208 no 566 0.171361036339401 196 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2058 5236698 133 µM 0.947444347335449 0.174282144672878 no 567 0.171706201135155 181 766665
SGTC_10 0279-0212 42.575 µM 0.946271442291688 0.174583488563239 no 568 0.172005077627252 183 39851 YBR002C RER2
SGTC_1074 carmofur 3.8 µM 0.94585954458416 0.174689392171261 no 569 0.172110115034156 213 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_405 ebelactone b 50 µM 0.944502298955234 0.175038644078037 no 570 0.172456513803304 165 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_828 2074-0507 139 µM 0.944361198194474 0.175074978097188 no 571 0.172492551302957 194 X828
SGTC_1121 fusaric acid 630.51 nM 0.943430058135965 0.175314870398881 no 572 0.172730487293254 169 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2051 5263410 176 µM 0.942611482094399 0.175525934573936 no 573 0.172939832306778 190 227584
SGTC_859 0439-0102 54.6 µM 0.941328314836168 0.175857114327795 no 574 0.173268318410668 211 610143
SGTC_2099 5377090 177.372 µM 0.938921352237379 0.176479407313386 no 575 0.173885562768014 202 2243829
SGTC_2769 toremifene 3.73 µM 0.93694733476873 0.176990805515748 no 576 0.174392824496541 213 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_351 caspofungin 25 nM 0.936586654280369 0.177084346166588 no 577 0.174485609753458 209 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2448 5185112 27.17 µM 0.93642801565764 0.177125498174232 no 578 0.174526429554155 176 5718189
SGTC_2789 5281112 71.43 µM 0.935353692891894 0.177404344240369 no 579 0.174803026498495 186 765948
SGTC_1362 1611-0397 101 µM 0.934962271433799 0.177506008562029 no 580 0.174903871643008 204 27816
SGTC_773 4358-1457 44.6 µM 0.93467943863199 0.177579491915077 no 581 0.174976763167314 211 1186886
SGTC_3065 9113888 49.47 µM 0.932253183137106 0.17821065071177 no 582 0.175602848175502 192 16648368
SGTC_1321 1326-2144 215 µM 0.932157559713368 0.178235554826758 no 583 0.175627552439191 212 3513030
SGTC_2751 anetholtrithion 17.25 µM 0.929802594370286 0.178849572825816 no 584 0.176236651413626 189 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1655 st012546 55.1 µM 0.929253380450088 0.178992962447216 no 585 0.17637889462452 186 720985 YLR208W SEC13
SGTC_153 4077-0274 519.67 µM 0.92838334182365 0.179220261497922 no 586 0.176604378194827 214 3121976
SGTC_2767 sibutramine 71.45 µM 0.928314539973644 0.179238243838978 no 587 0.176622217001296 181 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_128 0906-2981 13.371 µM 0.927587802743478 0.179428256230845 no 588 0.176810713558709 228 6740226
SGTC_2593 nobiletin 86.24 µM 0.927179518150916 0.179535061674332 no 589 0.176916667628995 189 72344 An anti-infammatory.
SGTC_830 4076-0286 57.8 µM 0.926040063248191 0.179833349359713 no 590 0.177212580151499 202 6866659
SGTC_1385 3091-4834 14.1 µM 0.923783781444005 0.180424919021333 no 591 0.177799450498858 167 4072814
SGTC_1497 4476-2978 41.3 µM 0.923196653120452 0.180579056882319 no 592 0.177952366350225 191 1528379
SGTC_2916 7875993 68.79 µM 0.923116458418244 0.180600116677926 no 593 0.177973259261103 217 1299250
SGTC_712 r015-0009 80.6 µM 0.922800232808994 0.180683175163069 no 594 0.178055659746239 191 6813872 YLR060W FRS1
SGTC_810 3825-7150 143 µM 0.921315372117961 0.18107350261092 no 595 0.178442898870196 171 22330411 YGL099W LSG1
SGTC_1504 k297-0033 30 µM 0.920230385789891 0.181359048290621 no 596 0.178726189343041 139 4388117
SGTC_1660 st012960 28.1 µM 0.919268432744164 0.181612449847577 no 597 0.178977592439613 195 24207266
SGTC_470 aa-861 153 µM 0.918346697262041 0.181855464891605 no 598 0.179218693474413 210 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1562 morin hydrate 59.1 µM 0.917898375470884 0.181973738168009 no 599 0.179336036117467 198 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2892 9047358 58.44 µM 0.917306696107851 0.182129904698456 no 600 0.179490974751538 184 6466771
SGTC_3311 9131146 2.8755 µM 0.913749698620097 0.183070495455803 no 601 0.180424191518426 227 4900406 YPR165W RHO1
SGTC_1951 sophoraflavanone G 9.2 µM 0.913173543995569 0.183223134972914 no 602 0.180575637873108 198 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2823 7987624 58.44 µM 0.911713459123244 0.183610307708566 no 603 0.180959788496807 224 2239440
SGTC_5 0352-0601 109.883 µM 0.906248296152479 0.185064033320042 no 604 0.182402222655691 191 762456
SGTC_2653 dihydrofissinolide 100 µM 0.904288493840789 0.185587074976602 no 605 0.182921223178329 204 6857746
SGTC_1485 3909-9022 254 µM 0.901156484053198 0.186424863316259 no 606 0.183752562156169 223 714516
SGTC_2455 5377712 9.75 µM 0.900757904447253 0.186531648052342 no 607 0.183858526936182 198 2243908
SGTC_291 SEC14.278 35.5 µM 0.90071605893899 0.186542861212961 no 608 0.18386965402282 198 1068044
SGTC_106 0092-0003 11.579 µM 0.898996505770128 0.187004003432639 no 609 0.184327260927761 195 1072148
SGTC_3129 9127257 49.47 µM 0.898980731196768 0.187008237050355 no 610 0.184331462129285 200 837894
SGTC_1622 st003707 19.4 µM 0.89892920451285 0.187022066318151 no 611 0.184345185513537 183 10140899
SGTC_1745 st081495 74 µM 0.898751768496442 0.187069693283495 no 612 0.184392447884048 209 13842402 YBL026W LSM2
SGTC_2614 arthonioic acid 13.39 µM 0.898276575738772 0.187197280371426 no 613 0.184519058724494 190 6710684
SGTC_308 4092-1169 104 µM 0.897818006781432 0.187320455052879 no 614 0.184641291555216 217 2268590 YDL196W YDL196W
SGTC_965 1291-5240 308 µM 0.894795435248438 0.188133590957054 no 615 0.185448225467564 214 2834598
SGTC_2591 skatole 100 µM 0.892443238613968 0.188767886620944 no 616 0.186077701997608 212 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1439 4092-1168 46 µM 0.891450435121957 0.189036002072656 no 617 0.186343785354036 213 2886240
SGTC_2043 5101342 149 µM 0.890996206531177 0.189158748731883 no 618 0.186465602672938 214 678451
SGTC_2979 9012552 45.46 µM 0.890876360483051 0.189191143034089 no 619 0.18649775181365 238 17100905
SGTC_2247 cerulenin 830 nM 0.889384277633523 0.189594737929295 no 620 0.186898295869858 208 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1037 k284-1091 78.7 µM 0.888438890166633 0.189850730588233 no 621 0.187152356875613 197 3334711
SGTC_3304 9125678 46.087 µM 0.88838876279558 0.189864310042256 no 622 0.187165833937092 215 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_147 4466-0538 29.23 µM 0.886763764445938 0.190304843872205 no 623 0.187603050093868 232 6742687 YHR072W ERG7
SGTC_2944 9067346 25.62 µM 0.884723551174872 0.190858829831701 no 624 0.188152875146644 212 6473075
SGTC_1046 2001-0062 216 µM 0.883977621221468 0.191061621449298 no 625 0.188354146734952 220 739778
SGTC_566 0958-0068 16.5 µM 0.883934578257652 0.191073327319374 no 626 0.188365764914213 227 6815365
SGTC_499 genistein 192 µM 0.883424687872564 0.191212029452504 no 627 0.188503428426229 226 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1887 st057648 70.8 µM 0.880815535765493 0.191922745564904 no 628 0.189208834792189 230 688672
SGTC_191 3914-0123 66.505 µM 0.880750433762839 0.191940499579473 no 629 0.189226456427834 219 3144412
SGTC_129 0088-0017 176.636 µM 0.880426846131387 0.192028760313222 no 630 0.189314059253348 203 182446
SGTC_2878 9043973 25.97 µM 0.877975461122605 0.192698198760557 no 631 0.189978517823764 210 6465167
SGTC_1912 st060209 90.8 µM 0.877757793710601 0.192757709497232 no 632 0.190037586739371 215 688787
SGTC_787 4152-0075 138 µM 0.87667068775849 0.19305509464613 no 633 0.190332766166142 208 9566539
SGTC_3256 9138902 49.47 µM 0.876584398172531 0.19307871173763 no 634 0.190356208240573 247 17228773
SGTC_643 k048-0106 28.4 µM 0.876466083290707 0.193111096883329 no 635 0.190388353428965 226 6763920
SGTC_2349 9023730 187.07 µM 0.876026274960765 0.193231510278805 no 636 0.190507874992124 207 4126287
SGTC_508 roscovitine 141 µM 0.875753103376286 0.193306323920543 no 637 0.190582134825474 232 160355 A CDKinase inhibitor.
SGTC_2436 5633522 8.09 µM 0.873759996618543 0.193852711896436 no 638 0.191124484962523 222 5724242
SGTC_1120 ficusin 1.78878 µM 0.872528561010492 0.19419076621321 no 639 0.191460047021784 218 6199 A DNA cross-linker.
SGTC_562 3772-2733 112 µM 0.868981744571737 0.195166444610517 no 640 0.19242855795763 207 2876874 YIL048W NEO1
SGTC_3245 9134821 49.47 µM 0.868690605683924 0.195246664846119 no 641 0.192508190572808 235 17014901
SGTC_2826 7992541 19.48 µM 0.868126370378936 0.195402190937739 no 642 0.192662578151336 265 2985066
SGTC_172 1112-0046 2.638 µM 0.864647501887754 0.196362769280194 no 643 0.193616145974426 206 2802135 YIL048W NEO1
SGTC_666 0272-0154 136 µM 0.8635298303827 0.196671985030953 no 644 0.193923112783794 218 6870312
SGTC_2254 7938975 95.19 µM 0.860710901693718 0.197453180749235 no 645 0.194698643673062 215 2969277
SGTC_2170 morpholine 200 µM 0.859251600047986 0.197858325803157 no 646 0.195100860310751 205 121171 Reacts with secondary amines.
SGTC_2232 chlorophetanol 41.5365 µM 0.858813160621397 0.197980147524072 no 647 0.195221802760914 219 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_847 0342-0274 5.54 µM 0.858335681108239 0.198112868169753 no 648 0.195353566135986 221 18097
SGTC_482 fipronil 114 µM 0.857673262494938 0.198297083593829 no 649 0.195536454023327 209 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_373 0844-0104 25.9 µM 0.856988311091529 0.198487673954935 no 650 0.195725672311871 221 5375804
SGTC_2610 ononetin 44.17 µM 0.855325990426226 0.198950680398423 no 651 0.196185351486122 212 259632
SGTC_1757 st041620 31.8375 µM 0.853508228244436 0.199457726328402 no 652 0.19668876331699 208 5289815
SGTC_645 0845-0943 5.41 µM 0.850438286046983 0.200315819130819 no 653 0.197540728921661 209 1885106
SGTC_2779 methotrexate 400 µM 0.846999030055925 0.20127977005603 no 654 0.198497831041446 225 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2516 gossypol 71.55 µM 0.845742717594324 0.201632580242647 no 655 0.198848143575809 227 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2849 9019321 12.99 µM 0.845618111900918 0.201667593437346 no 656 0.198882909165077 227 16489627
SGTC_43 0570-0105 72.5 µM 0.844049199841369 0.202108756594893 no 657 0.19932095659273 225 1114046 YDL195W SEC31
SGTC_2374 9071832 200 µM 0.844015925850559 0.202118119174115 no 658 0.199330253130223 217 17381698
SGTC_1330 1469-0054 61.8 µM 0.843090987173979 0.202378480715241 no 659 0.199588779494766 228 7102664
SGTC_1252 0493-0875 34.8 µM 0.842791485246386 0.202462830660511 no 660 0.199672535456699 196 3960963
SGTC_160 3453-0671 289.699 µM 0.842023979905565 0.202679082239872 no 661 0.199887265473641 236 5322268
SGTC_1826 st055655 41.6 µM 0.837424943313565 0.203977791559861 no 662 0.201176874982527 224 676168
SGTC_2056 5235370 200 µM 0.83614655146272 0.204339671934128 no 663 0.201536231310538 211 5511916
SGTC_2768 sulfasalazine 50.2 µM 0.834679367891876 0.204755465178914 no 664 0.20194913069285 231 5384001 An antioxidant and salicylic acid derivative.
SGTC_2211 7117706 200 µM 0.834322436838571 0.204856693889385 no 665 0.202049655870729 213 822771
SGTC_818 4072-2707 53.5 µM 0.834247475830137 0.204877957255494 no 666 0.202070771507883 218 882871
SGTC_9 0092-0002 10.449 µM 0.833014666018163 0.205227843109256 no 667 0.202418228991892 242 759368
SGTC_3258 9138477 49.47 µM 0.83216483538985 0.20546924156927 no 668 0.202657954770246 239 4970355
SGTC_441 propafenone 146 µM 0.831789964177292 0.205575779101955 no 669 0.202763754800134 249 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_210 3551-0445 56.827 µM 0.831738153957454 0.205590506025753 no 670 0.202778379811434 228 2865180 YOR207C RET1
SGTC_3337 9144342 33.5465 µM 0.831369604563867 0.205695283329524 no 671 0.202882432280298 221 17682949
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.831299509403506 0.205715214724892 no 672 0.202902225840579 196 6857784
SGTC_1628 st004252 77.7 µM 0.830514903765013 0.205938393716751 no 673 0.203123862481004 219 692968
SGTC_2985 9022375 71.43 µM 0.830412721318475 0.205967469808977 no 674 0.203152737773592 237 4939335
SGTC_1548 st061468 90.8 µM 0.830271870261574 0.206007553074616 no 675 0.203192544276973 229 390799
SGTC_2067 5224629 34.075 µM 0.829230487023832 0.206304052489633 no 676 0.203486998363617 218 2835000
SGTC_2966 9084041 48.03 µM 0.825601909965023 0.207339143832147 no 677 0.204514975666228 209 17741380
SGTC_2386 9075165 157.42 µM 0.824356109758227 0.207695228855882 no 678 0.204868622793936 227 16452277
SGTC_2087 5276107 200 µM 0.823872046354121 0.20783368530481 no 679 0.205006132617024 236 144405
SGTC_1876 myriocin 605 nM 0.823649212690119 0.207897440640554 no 680 0.205069452302675 252 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_469 w7 172 µM 0.82319888548212 0.20802631980514 no 681 0.205197451287034 220 45115570 A P450 inhibitor.
SGTC_3296 9122258 64.045 µM 0.823042266765385 0.20807115357426 no 682 0.205241979011676 211 4730474
SGTC_438 sphingosine 6.67 µM 0.822818961655539 0.208135086892835 no 683 0.205305476040214 215 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2332 7982454 138.89 µM 0.822667922055075 0.208178336823258 no 684 0.205348430914871 255 2981748
SGTC_896 0964-0007 44.5 µM 0.822483118690402 0.208231262163196 no 685 0.205400995288831 219 6756758
SGTC_201 4262-0159 12.803 µM 0.820252778022626 0.208870629284009 no 686 0.206036010126274 218 1341029
SGTC_132 0417-1715 25.805 µM 0.818343825171686 0.20941878232777 no 687 0.206580444107541 227 6769098
SGTC_2957 9076800 11.52 µM 0.81803212471423 0.209508366983315 no 688 0.206669422035514 229 16459615
SGTC_3032 9089427 49.47 µM 0.816266719236506 0.210016180800812 no 689 0.207173802316908 213 17173707
SGTC_1556 plumbagin 1.48 µM 0.815943741144287 0.210109162720187 no 690 0.207266156600228 239 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2836 9010338 19.48 µM 0.815452907075535 0.210250514862646 no 691 0.207406555226987 232 2994051
SGTC_1937 st074714 47.2 µM 0.81463021124326 0.210487562944262 no 692 0.207642005946832 206 17250970
SGTC_1976 st070609 63.5 µM 0.814052552624515 0.210654100744256 no 693 0.207807422786324 224 682556
SGTC_3099 9120367 49.47 µM 0.813756721167334 0.210739418273535 no 694 0.207892166449893 257 24824940
SGTC_2720 fluspirilene 36.88 µM 0.812443565973513 0.211118375661635 no 695 0.208268578185551 231 3396 An atypical antipsychotic.
SGTC_1394 3474-0001 65.7 µM 0.812241706985346 0.2111766646083 no 696 0.20832647605356 196 5017666 YIL048W NEO1
SGTC_3338 9144300 39.5675 µM 0.810842623729259 0.211580924015497 no 697 0.208728026664429 203 4901274
SGTC_895 0964-0006 13.7 µM 0.810592738010649 0.211653175131664 no 698 0.208799794297006 260 6738897
SGTC_412 gemfibrozil 100 µM 0.809908868710047 0.211850980628238 no 699 0.208996277136427 211 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_81 0411-0046 9.971 µM 0.809168306174692 0.212065306264858 no 700 0.209209171304124 246 12925265
SGTC_719 2810-4230 27.3 µM 0.808678625347264 0.212207094029921 no 701 0.209350013020776 223 721079
SGTC_3272 9137413 49.47 µM 0.807927184538332 0.212424782496858 no 702 0.209566250470413 241 17614870
SGTC_2388 9080168 200 µM 0.807642258671789 0.212507358131198 no 703 0.209648276154306 260 15943073
SGTC_617 3770-0098 35 µM 0.807332197907361 0.21259723952386 no 704 0.209737559229823 236 5962639
SGTC_2261 9010538 184.68 µM 0.806909156030578 0.212719908042509 no 705 0.20985941166248 270 6457250
SGTC_237 nikkomycin 200 µM 0.804692700293857 0.213363283930001 no 706 0.210498516503381 240 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1326 1431-2094 10.8 µM 0.801217071216151 0.214374443888604 no 707 0.21150299500793 244 616278
SGTC_2414 st077232 92.9 µM 0.79941834177593 0.214898838242988 no 708 0.212023939258188 217 729801
SGTC_1518 st038567 90.8 µM 0.798184238563068 0.215259054297213 no 709 0.212381791273217 260 77966
SGTC_3209 9113616 49.47 µM 0.798080383730168 0.215289383928213 no 710 0.212411922074897 244 16649353
SGTC_3051 9093778 49.47 µM 0.797421645117811 0.215481818841379 no 711 0.21260309625165 268 17217378
SGTC_371 0195-0006 7.36 µM 0.79731798439052 0.215512109955078 no 712 0.212633189037936 233 3928593
SGTC_133 0724-0033 378.92 µM 0.796638970319907 0.215710588422392 no 713 0.212830368830079 229 280309
SGTC_2110 5483698 200 µM 0.796601397043609 0.215721574331156 no 714 0.212841282898842 229 2848765 YHR062C RPP1
SGTC_1475 4092-1048 11.7 µM 0.796266760149007 0.215819431859671 no 715 0.212938500705581 236 2881759
SGTC_660 4031-1742 102 µM 0.795902046004528 0.215926114142345 no 716 0.213044485979301 237 6738706
SGTC_34 0469-0683 81.75 µM 0.794598368832131 0.216307701578417 no 717 0.213423583748948 217 3690923
SGTC_1369 1866-0067 208 µM 0.792980991495109 0.216781651468382 no 718 0.213894448823423 236 3531355
SGTC_2245 6637752 200 µM 0.79187401790282 0.217106380495739 no 719 0.214217069045988 226 681890
SGTC_1674 st016616 23.6 µM 0.791838495314032 0.21711680564538 no 720 0.214227426558461 227 625830
SGTC_1516 st013856 110 µM 0.791495601773652 0.217217452721006 no 721 0.214327420852843 228 5281404 A mutagen and neurotoxin.
SGTC_1141 3253-0389 52.6 µM 0.790975315163259 0.217370220167117 no 722 0.214479198184088 253 5402031
SGTC_1225 1216-0074 20.6 µM 0.790649034814256 0.217466054805162 no 723 0.21457441213699 246 4241466
SGTC_2467 5474540 200 µM 0.790036425155989 0.217646055588411 no 724 0.214753248033453 232 5413519
SGTC_831 k061-1017 217 µM 0.788682356894961 0.218044221231486 no 725 0.215148841142439 257 1240153
SGTC_1684 st024538 14.6195 µM 0.787515514163919 0.218387669532703 no 726 0.215490075101491 233 6732859
SGTC_1782 st039423 80.636 µM 0.786875123297517 0.218576294435424 no 727 0.215677485703809 231 2068169
SGTC_1257 0669-0121 16 µM 0.785780494314994 0.218898930690676 no 728 0.215998047956087 250 4307855
SGTC_1929 genistein trimethyl ether 50.5 µM 0.785269719281358 0.219049572698524 no 729 0.216147722893986 228 136420
SGTC_1356 1502-0781 85.8 µM 0.785060757264127 0.219111218689029 no 730 0.216208973377292 238 567702
SGTC_3160 9100216 49.47 µM 0.78141452594591 0.220188499745747 no 731 0.217279365198707 234 17191039
SGTC_1060 3448-7350 82 µM 0.780097635645189 0.220578321074423 no 732 0.217666704018441 239 570178
SGTC_3192 9110362 49.47 µM 0.779434595542472 0.220774741484331 no 733 0.217861875650765 255 16649480
SGTC_3324 9138759 60.749 µM 0.779049013677724 0.22088901312175 no 734 0.217975421430322 244 45595710
SGTC_1218 1348-1416 30.7 µM 0.778898960740884 0.220933492193221 no 735 0.218019618097108 249 6787668
SGTC_2833 9001315 45.46 µM 0.774280314735015 0.222305068356021 no 736 0.21938252108003 240 2989378
SGTC_3 0833-0587 95.581 µM 0.773437715477582 0.222555813764017 no 737 0.219631688249756 239 5382644
SGTC_1949 st076024 69.1 µM 0.769560501952011 0.223711692743594 no 738 0.22078032121338 266 2921930
SGTC_2154 5570129 200 µM 0.768057611635626 0.22416065224167 no 739 0.221226479216353 274 673366
SGTC_2299 7976368 114.88 µM 0.766541990585434 0.22461393255806 no 740 0.221676938414639 235 2979718
SGTC_2621 lithochol-11-enic acid 100 µM 0.765726864399464 0.224857929102135 no 741 0.221919419426458 245 6708711
SGTC_553 k007-0256 45.7 µM 0.764595180400833 0.225196931767641 no 742 0.222256319987668 238 6287000
SGTC_2750 bromebric acid 70.15 µM 0.764309064798568 0.225282685223133 no 743 0.222341542350536 236 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2105 5350118 200 µM 0.763838862513854 0.225423652583479 no 744 0.222481637236107 244 2133313
SGTC_111 0083-0039 52.457 µM 0.763389701256004 0.225558358434786 no 745 0.222615510029988 213 759313
SGTC_1203 3992-3522 103 µM 0.763176719425569 0.225622248737829 no 746 0.222679005444785 262 5322312
SGTC_2875 9039966 71.43 µM 0.763103465871241 0.225644225710215 no 747 0.222700846617303 249 6463691
SGTC_3188 9110789 49.47 µM 0.76264067281372 0.225783097346919 no 748 0.222838860538754 249 849217
SGTC_1322 1348-1070 12 µM 0.762608271331969 0.225792821962686 no 749 0.222848525118009 257 6758089
SGTC_2383 9036125 200 µM 0.761555704332221 0.226108856385897 no 750 0.223162610287831 251 79580
SGTC_2482 5981709 142.65 µM 0.757507009916454 0.227326808867484 no 751 0.224373083901467 256 877755
SGTC_1108 betulinic acid 729.144 nM 0.757478318918497 0.22733545303501 no 752 0.22438167517783 226 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_912 3474-0017 2.18 µM 0.757144069657045 0.227436170971477 no 753 0.224481777045954 250 3360550
SGTC_1007 4101-0031 70 µM 0.756177816752316 0.227727469238876 no 754 0.224771295536259 269 1146276
SGTC_1744 st037937 38.9 µM 0.756123092881318 0.227743973238956 no 755 0.224787698790169 256 1016152
SGTC_1519 esterone 74 µM 0.755217787388227 0.228017099144722 no 756 0.22505915884294 247 698 A steroid.
SGTC_3301 9125354 19.7965 µM 0.754334202163704 0.228283849724502 no 757 0.225324285006381 234 41905162
SGTC_622 1348-1566 26.3 µM 0.754203131744895 0.228323434254536 no 758 0.225363628695446 250 7340407
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.753587417352936 0.22850943755354 no 759 0.225548501052316 254 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_353 1988-1175 58.3 µM 0.747027022880121 0.230496567041671 no 760 0.227523624605519 266 2788357
SGTC_808 0711-0032 135 µM 0.746232300848576 0.230737940805143 no 761 0.227763549500508 255 4252555
SGTC_3196 9111891 49.47 µM 0.745518053629686 0.230954993095259 no 762 0.22797930066227 277 18891510
SGTC_2062 5245942 200 µM 0.741902183346804 0.23205556587 no 763 0.229073301447717 249 1376160
SGTC_189 3970-0742 2.116 µM 0.741538268550207 0.232166493140168 no 764 0.229183568677626 252 2891807
SGTC_757 1066-0008 322 µM 0.741360416381441 0.232220716167108 no 765 0.229237469222948 240 6842497
SGTC_2956 9076196 2.52 µM 0.74094031108344 0.2323488245682 no 766 0.229364816131005 288 16423868
SGTC_1999 st074831 12.5 µM 0.740671356829132 0.2324308610708 no 767 0.229446365299311 259 17112523
SGTC_78 0336-0123 156.75 µM 0.739963629062868 0.232646809344304 no 768 0.22966103186585 241 6765896
SGTC_3285 9112818 20.8695 µM 0.73890295295674 0.232970661117341 no 769 0.229982964550359 271 17017947 YPR165W RHO1
SGTC_2487 5918373 44.05 µM 0.738447852022334 0.233109691896538 no 770 0.230121172580651 266 2876279
SGTC_961 1252-1571 372 µM 0.73801877905514 0.233240813455879 no 771 0.230251518813591 268 6813498
SGTC_2081 5214970 32.255 µM 0.737973913830541 0.23325452630378 no 772 0.230265150611564 239 2063512
SGTC_2712 st079126 47.7 µM 0.737577234063514 0.233375789100954 no 773 0.230385696969012 254 3152970
SGTC_1087 pterostilbene 9.05 µM 0.734865813946554 0.234205591075263 no 774 0.231210610083749 275 5281727 Similar to reservatol, lowers cholesterol.
SGTC_985 1493-0307 8.71 µM 0.734691987089492 0.234258844640258 no 775 0.231263550718109 261 3278274
SGTC_2998 9066762 71.4286 µM 0.734310797221286 0.234375649363482 no 776 0.231379669414095 255 4945196
SGTC_1919 st067113 52.3 µM 0.734122653363627 0.234433312540335 no 777 0.231436994093537 280 1268243
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.733638968398574 0.234581590510486 no 778 0.23158440216485 260 6710655
SGTC_2972 9093619 59.92 µM 0.733454881474433 0.234638037635412 no 779 0.231640518333401 235 25236256
SGTC_1647 st011722 22.4 µM 0.733073154185348 0.234755111751255 no 780 0.231756906382006 247 2854783
SGTC_1447 4239-0816 81.9 µM 0.732778955647902 0.234845363207317 no 781 0.231846629279232 252 1341554
SGTC_1814 st052110 31.539 µM 0.732655260583369 0.234883314939967 no 782 0.231884358831462 267 674163
SGTC_3066 9117245 49.47 µM 0.732031986444385 0.235074597520626 no 783 0.232074522348934 250 17176980
SGTC_2366 9070441 60.58 µM 0.731173319767962 0.235338262849213 no 784 0.232336647231554 251 6837235
SGTC_1104 tacrolimus 29.8 µM 0.73055887048063 0.235527038053923 no 785 0.232524321009867 257 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2513 baicalein 25.65 µM 0.72685361829632 0.236667159389621 no 786 0.233657816401766 263 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2085 5307070 144.047 µM 0.726532394331923 0.236766144133464 no 787 0.233756228002456 280 2840351
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.723434675326013 0.237721869690741 no 788 0.234706437067948 253 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3276 9139060 49.47 µM 0.722804465499989 0.237916564291763 no 789 0.234900011736778 288 4870619
SGTC_1720 st037298 9.481 µM 0.721108004274105 0.2384410966756 no 790 0.235421533359137 268 597396
SGTC_1609 st001574 46.4 µM 0.720513410200938 0.23862509020075 no 791 0.235604473017846 276 3960012
SGTC_998 3996-0085 177 µM 0.720170860654145 0.238731125343947 no 792 0.235709901347028 266 715391
SGTC_3184 9108758 49.47 µM 0.719918798918006 0.238809166728461 no 793 0.235787496365428 272 902885
SGTC_2618 avocadyne 43.43 µM 0.719518782303551 0.238933045386781 no 794 0.235910666915043 259 3015189
SGTC_1526 st051518 75 µM 0.717435244325027 0.239578851124092 no 795 0.236552789641987 262 673993
SGTC_1822 st052468 42 µM 0.716881906676005 0.239750521612012 no 796 0.236723483498892 266 2873678
SGTC_1653 st012112 65 µM 0.716656355988841 0.239820516937331 no 797 0.236793080910869 262 720429
SGTC_1089 terbinafine 2.25 µM 0.715663270065605 0.240128834646472 no 798 0.237099647870578 263 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_688 0527-0193 473 µM 0.715454123659909 0.240193794667654 no 799 0.237164239437161 295 4007154
SGTC_3302 9125395 16.351 µM 0.714033651149761 0.240635240950023 no 800 0.237603185640646 250 17599668
SGTC_837 0091-0265 12.5 µM 0.713736561142425 0.240727624687972 no 801 0.237695047015029 276 759367
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.71357863129716 0.240776742743785 no 802 0.237743887462006 269 676296 Flavone; oxidizing agent.
SGTC_674 0498-0004 451 µM 0.711920547671744 0.241292755464392 no 803 0.238256988711808 258 4231473
SGTC_433 pimozide 108 µM 0.711659801037008 0.241373957151985 no 804 0.238337733064741 263 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2630 antimycin a 100 µM 0.71124350143326 0.241503631894741 no 805 0.238466677933567 280 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1056 3448-1962 115 µM 0.711213848663956 0.241512869991587 no 806 0.238475864055628 263 715507
SGTC_383 2324-0395 7.37 µM 0.711150888143319 0.241532485503712 no 807 0.238495369217844 248 3146421
SGTC_488 nitrendipine 139 µM 0.710753345908065 0.241656360785059 no 808 0.238618547922932 261 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3312 9133330 71.43 µM 0.709387199136791 0.24208231876218 no 809 0.239042114628831 277 17617324
SGTC_879 0831-1030 162 µM 0.708976363034021 0.242210495060404 no 810 0.239169572568119 266 1549252
SGTC_2013 4024628 200 µM 0.708675853952688 0.24230427384473 no 811 0.239262826126105 281 5230760
SGTC_571 k831-0106 44.2 µM 0.708107563396497 0.242481672004616 no 812 0.239439231548826 281 4783639
SGTC_1327 1436-0082 2.18 µM 0.707123148194111 0.242789134468723 no 813 0.239744975949949 270 15992205
SGTC_3031 9088762 49.47 µM 0.707103092976517 0.242795400508485 no 814 0.239751207009141 268 205253
SGTC_587 k089-0003 57 µM 0.706966549544093 0.242838064380322 no 815 0.23979363274252 270 9659696
SGTC_3035 9091303 49.47 µM 0.706102365892538 0.243108178175658 no 816 0.240062240264241 279 25237002
SGTC_713 1488-1073 324 µM 0.70477655116131 0.243522897453998 no 817 0.240474651689521 281 3312542
SGTC_2471 5466956 24.79 µM 0.704028392545324 0.243757092526582 no 818 0.240707546068764 265 724419
SGTC_708 3448-5400 146 µM 0.703469337159753 0.243932172208296 no 819 0.240881654587518 282 3462195
SGTC_2002 4023503 131 µM 0.703173990012391 0.244024693619981 no 820 0.240973663202974 283 4736863 YCR052W RSC6
SGTC_83 0170-0301 39.027 µM 0.70312023022735 0.24404153662193 no 821 0.240990412884341 265 3089716
SGTC_2321 7390090 138.78 µM 0.700513114349571 0.244859101073022 no 822 0.241803459027004 274 649046
SGTC_1264 0783-0040 158 µM 0.698686944948909 0.245432645527275 no 823 0.242373847193784 269 2855798
SGTC_2872 9044037 25.97 µM 0.698662990030794 0.245440173834889 no 824 0.242381334145721 265 6465195
SGTC_1960 st011366 51.8 µM 0.698635306573236 0.245448874064448 no 825 0.242389986584191 287 3972846
SGTC_2723 salbutamol 83.58 µM 0.697389618718093 0.245840534547258 no 826 0.242779498277058 271 9884233 β2-adrenoceptor agonist
SGTC_339 3091-4833 71.4 µM 0.696198032906592 0.246215498336051 no 827 0.243152409704753 272 3240077
SGTC_720 r052-1644 49.9 µM 0.695678724607717 0.24637900823385 no 828 0.243315026108991 267 1422863 YOR257W CDC31
SGTC_1672 st016598 6.51 µM 0.695241089069164 0.246516847745651 no 829 0.243452113098177 276 4665860 YNL267W PIK1
SGTC_3352 9151559 45.5865 µM 0.693402792793782 0.247096296189197 no 830 0.244028405053641 258 17159339
SGTC_3094 9117742 49.47 µM 0.69238011858001 0.247418967932762 no 831 0.244349323943963 291 17149698
SGTC_2429 5902844 64.44 µM 0.692164691433273 0.24748696769888 no 832 0.244416954758168 281 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_486 niguldipine 82 µM 0.69190337961704 0.247569464402141 no 833 0.244499004059685 260 1236 A calcium channel blocker.
SGTC_749 1000-0129 128 µM 0.689837298981226 0.248222247445173 no 834 0.245148254896737 274 708470
SGTC_995 3931-2021 34.6 µM 0.688660553624023 0.248594452764121 no 835 0.24551845257559 274 730143
SGTC_2210 7115885 190.385 µM 0.687549760965981 0.248946069800335 no 836 0.245868177260982 285 2927039
SGTC_2354 9060492 162 µM 0.684393955411186 0.249946470010379 no 837 0.246863215950927 277 6471895
SGTC_1216 1165-0504 9.65 µM 0.683964651819028 0.250082725260064 no 838 0.246998743528703 280 6304004
SGTC_672 1441-0018 53.7 µM 0.68384975481364 0.25011919872449 no 839 0.247035022310863 262 251141
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.683812247033757 0.250131105987534 no 840 0.24704686602676 282 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3009 9080819 71.4286 µM 0.683570017105036 0.250208011820722 no 841 0.247123361539125 268 17027216
SGTC_1378 2093-0007 380 nM 0.68351224881073 0.25022635458856 no 842 0.247141606470531 294 3618014
SGTC_1235 benzylparaben 21.5 µM 0.682419726869908 0.250573389768084 no 843 0.247486792738981 289 7180
SGTC_624 k048-0052 28 µM 0.680883102885288 0.251061923357234 no 844 0.247972730309353 270 6835531
SGTC_1127 asiatic acid 681.4 nM 0.680427014341125 0.251207022943262 no 845 0.248117060371389 282 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3110 9122132 49.47 µM 0.678119670964118 0.251941758185569 no 846 0.248847909683237 256 918317
SGTC_823 0417-1665 178 µM 0.677100740205528 0.252266580423799 no 847 0.24917101965289 293 3429856
SGTC_284 0988-0104 32.6 µM 0.676547258137488 0.252443116012022 no 848 0.249346626109817 286 4666532
SGTC_2310 7668677 200 µM 0.676289084012224 0.252525484069196 no 849 0.249428561003761 290 2197143
SGTC_1896 st058441 89 µM 0.676238610202118 0.252541588924231 no 850 0.249444581191511 268 688759
SGTC_479 n-linoleoylglycine 10 µM 0.67503493229333 0.252925810912026 no 851 0.249826785759328 284 6433346 An anti-infammatory.
SGTC_742 0kpi-0133 140 µM 0.674033701951021 0.253245644521291 no 852 0.250144943734464 277 2728852
SGTC_213 1246-0773 967 nM 0.673863086730577 0.253300167146773 no 853 0.250199181047025 277 6251622
SGTC_586 0957-0265 8.15 µM 0.67383694684856 0.253308521079114 no 854 0.250207491272479 274 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1146 3579-1023 7 µM 0.673623456343497 0.253376755012323 no 855 0.250275368298859 296 X1146
SGTC_1527 coumarin 137 µM 0.67202683177031 0.253887360073629 no 856 0.250783307424745 313 323 A hepatotoxic, DNA x-linker.
SGTC_2243 6634756 200 µM 0.671571664492114 0.254033022722592 no 857 0.250928211118817 240 885676
SGTC_2294 7971431 200 µM 0.670656449132615 0.254326042633918 no 858 0.251219706398406 313 5741572
SGTC_2717 st081029 62.2815 µM 0.670085859451623 0.254508815092805 no 859 0.25140152928655 287 5292846
SGTC_2534 helenine 20.12 µM 0.669995097929547 0.254537894352682 no 860 0.251430457569785 266 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1194 1488-0194 225 µM 0.669526145633197 0.254688170613673 no 861 0.2515799540526 282 1391452
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.669265793204249 0.25477162087823 no 862 0.251662971615981 267 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1446 4239-0190 62 µM 0.668942797870813 0.254875169845303 no 863 0.251765983984197 276 1340085
SGTC_2854 9024559 71.43 µM 0.667485607408562 0.255342603765903 no 864 0.252230999990605 284 3163529
SGTC_2264 7948757 110.76 µM 0.666588735582998 0.255630522673839 no 865 0.252517433122851 276 2971411
SGTC_509 pifithrin 175 µM 0.66649312711928 0.255661225445601 no 866 0.25254797761589 296 4817 A p53 inhibitor.
SGTC_1833 st055984 71 µM 0.664632649154507 0.256259064351858 no 867 0.25314274067808 270 676288
SGTC_771 0250-0039 27.3 µM 0.664579677523928 0.256276096718076 no 868 0.253159685584605 291 3005115
SGTC_786 4544-0069 423 µM 0.662864958617642 0.256827761737258 no 869 0.253708522963118 278 748821 YLR208W SEC13
SGTC_936 3005-4620 401 µM 0.66223175015762 0.257031635797731 no 870 0.253911354544257 295 777207
SGTC_1808 st050063 61.5 µM 0.661083320291343 0.257401610315332 no 871 0.254279440705181 300 4011993
SGTC_878 0828-0289 13.7 µM 0.660237833053592 0.25767416653941 no 872 0.254550608642846 289 745350 YLR208W SEC13
SGTC_2301 7769476 200 µM 0.655768158007833 0.259117523116315 no 873 0.25598665353633 292 977820
SGTC_3088 9117578 49.47 µM 0.654702887445139 0.25946213826197 no 874 0.256329532922 295 678341
SGTC_1163 k060-0048 49.9 µM 0.653395256946522 0.259885480275712 no 875 0.256750747895945 280 6809982
SGTC_2300 7976697 71.57 µM 0.650922181857106 0.260687105067048 no 876 0.25754836084493 271 2236109
SGTC_595 3909-8003 73.7 µM 0.649263691250493 0.261225401659445 no 877 0.258083975075108 298 699517
SGTC_1698 5-fluorocytosine 1.055 µM 0.648107798507452 0.261600907431316 no 878 0.258457615199094 288 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3037 9091026 49.47 µM 0.647888605291127 0.261672146242236 no 879 0.258528500581335 285 25236398 YIL048W NEO1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.647321286243779 0.261856573776508 no 880 0.258712013894346 277 1241132 A phosphatase inhibitor.
SGTC_1605 st000082 49.1 µM 0.647281267900575 0.261869585700162 no 881 0.258724961358156 284 1114022
SGTC_1486 3970-0793 4.53 µM 0.646772817383075 0.262034936735949 no 882 0.258889493733857 306 2844330
SGTC_2253 7938677 135.83 µM 0.643624179791897 0.263060082365997 no 883 0.259909583391338 274 2301972
SGTC_1646 st011709 75.6 µM 0.641894442044544 0.263624128081514 no 884 0.260470861608086 286 5757843
SGTC_384 k007-0144 5.16 µM 0.641797950490397 0.263655610923677 no 885 0.260502190278923 300 6824886
SGTC_1013 4112-3890 241 µM 0.641728969246334 0.263678118997869 no 886 0.2605245881506 291 705171
SGTC_988 1497-1057 103 µM 0.641581577090506 0.263726215262097 no 887 0.260572448983392 299 3533044
SGTC_3006 9075424 71.4286 µM 0.641185144790265 0.263855599247478 no 888 0.260701200000346 284 7465181
SGTC_3185 9108267 49.47 µM 0.639909237213785 0.264272237989347 no 889 0.261115804106523 288 4910486
SGTC_779 1360-0071 233 µM 0.639723590986574 0.264332887378614 no 890 0.261176157779228 287 7566
SGTC_3280 9140961 49.47 µM 0.639621357094837 0.26436628953732 no 891 0.26120939712454 306 4901226
SGTC_2320 7373003 200 µM 0.639228083905179 0.264494800941282 no 892 0.261337282452343 273 5415828
SGTC_2608 thymoquinone 42.66 µM 0.638662877044354 0.264679551434264 no 893 0.261521133808638 290 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3241 9133421 49.47 µM 0.638594266435025 0.264701982811398 no 894 0.261543456091657 324 17018221
SGTC_1250 0485-0349 40.2 µM 0.637751582563646 0.264977566553644 no 895 0.261817700851528 295 6842794 YDL195W SEC31
SGTC_278 4092-0821 23.9 µM 0.637590980897041 0.265030104811104 no 896 0.261869984115181 286 877900
SGTC_2895 9054447 58.44 µM 0.637362482909021 0.26510486338054 no 897 0.261944379996283 305 2697450
SGTC_156 3474-0145 5.642 µM 0.63567028239846 0.265658840340894 no 898 0.262495674899944 277 2265471
SGTC_2561 acetosyringone 100 µM 0.635619820939879 0.265675368955555 no 899 0.262512123641932 313 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.635487752909822 0.265718630212425 no 900 0.262555175884744 294 2374 Ca(2+)-ATPase inhibitor.
SGTC_2943 9068529 45.32 µM 0.635367469876288 0.265758034189287 no 901 0.262594389535517 313 3270634
SGTC_3212 9128307 49.47 µM 0.634970795950134 0.265888003099589 no 902 0.262723731029618 287 27243542
SGTC_2961 9083290 32.55 µM 0.632840514263826 0.266586533406942 no 903 0.263418898416467 287 17741490
SGTC_445 e6 berbamine 66 µM 0.632602165663177 0.266664746819887 no 904 0.263496736251854 294 6610268 A calcium/calmodulin antagonist.
SGTC_1847 st056231 15 µM 0.632450007426252 0.266714683176982 no 905 0.263546432918079 287 5393180
SGTC_1680 diphenhydramine 100 µM 0.631988663839644 0.266866119036658 no 906 0.26369714237996 283 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2011 4012611 177 µM 0.631607776370592 0.266991177935567 no 907 0.263821601952222 292 2049887
SGTC_1994 st072947 40.9 µM 0.631121616724759 0.26715084442111 no 908 0.263980503979264 309 5286565 YDL195W SEC31
SGTC_2017 5132927 60.65 µM 0.630983433551631 0.267196235884214 no 909 0.264025678262415 291 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.629322127098331 0.267742259051198 no 910 0.26456909403704 294 4330530
SGTC_3022 9087993 49.47 µM 0.628435374693977 0.268033938780085 no 911 0.264859384788045 296 17173644
SGTC_747 3448-8087 38.7 µM 0.628117374031415 0.268138577788277 no 912 0.264963526160778 313 5168703
SGTC_2865 9030313 51.95 µM 0.627565846048189 0.268320108351692 no 913 0.265144194233094 289 42562754
SGTC_3242 9133940 49.47 µM 0.627231162125923 0.268430296738309 no 914 0.265253859598158 293 17248444
SGTC_2913 7966556 36.57 µM 0.626394967102866 0.268705697625568 no 915 0.265527954939556 277 2976516
SGTC_2337 9009472 200 µM 0.625873221616541 0.268877606427723 no 916 0.265699050015682 303 5742383
SGTC_3182 9108849 49.47 µM 0.624664467849594 0.269276088182041 no 917 0.266095649148199 281 17133045
SGTC_944 3370-0224 231 µM 0.624385429122058 0.269368119070099 no 918 0.266187245948488 281 4580514
SGTC_819 1013-0258 27.7 µM 0.623143217167032 0.269778009283168 no 919 0.266595206044715 301 5753198
SGTC_2240 6690706 185.951 µM 0.620984244602649 0.270491143520908 no 920 0.267304994821274 279 805876
SGTC_2815 7968870 71.43 µM 0.620155436150424 0.270765158761825 no 921 0.267577728846963 301 2977326 YHR190W ERG9
SGTC_1349 flufenamic acid 69 µM 0.619591304855948 0.270951747398715 no 922 0.267763446398034 298 3371 A non-steroidal anti-inflammatory.
SGTC_2569 tetrandrine 100 µM 0.614557151238466 0.272619648756114 no 923 0.269423609619483 273 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1664 st014217 9.02 µM 0.613435108007193 0.272992094223243 no 924 0.269794339023182 301 3982782
SGTC_3149 9097855 49.47 µM 0.609780858702975 0.274206813486187 no 925 0.271003491448549 283 25236625 YMR079W SEC14
SGTC_296 1222-0039 74.9 µM 0.60911826553466 0.274427353503456 no 926 0.271223025697125 283 5984176
SGTC_1728 st035614 33.7865 µM 0.608069073297527 0.274776749582263 no 927 0.271570831456008 315 15945546
SGTC_3103 9120822 49.47 µM 0.607933700072684 0.274821846778441 no 928 0.271615723662978 322 17141819
SGTC_1090 efavirenz 20.7 µM 0.606715409830271 0.275227862714636 no 929 0.272019896897504 303 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_134 0269-0018 6.916 µM 0.606251879458062 0.275382419605833 no 930 0.272173753676988 308 4378915
SGTC_3227 9130768 49.47 µM 0.60563432785153 0.275588398775918 no 931 0.272378800954108 316 17720899
SGTC_1904 st060225 78 µM 0.605387403669813 0.275670779467122 no 932 0.27246080930595 281 66595
SGTC_2495 cafestol 54.53 µM 0.604972534936741 0.27580921832627 no 933 0.272598622930964 311 16667697 An anti-infammatory.
SGTC_1113 artemisinin 1.17947 µM 0.604902584759107 0.275832563587381 no 934 0.272621862815916 313 2240 An anti-malaria and mitochondrial poison.
SGTC_852 0418-0143 439 µM 0.604544979319285 0.275951926448185 no 935 0.272740687158798 289 5369229
SGTC_2984 9022109 38.96 µM 0.604387249899537 0.276004582016407 no 936 0.272793105306209 323 6459207
SGTC_567 1080-0542 68.4 µM 0.60263521000695 0.276589805469409 no 937 0.273375695798017 275 5950415
SGTC_195 4234-0266 16.654 µM 0.601643271026611 0.276921406384723 no 938 0.273705809518234 312 2303354
SGTC_2117 5521686 200 µM 0.599950338439891 0.277487795658551 no 939 0.274269666450262 298 803312
SGTC_1943 st076331 65.2 µM 0.599486839737291 0.27764296293267 no 940 0.274424141694786 310 24208415
SGTC_3079 9117512 49.47 µM 0.59854894886556 0.277957073932904 no 941 0.274736854065688 356 7185044
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.597036419716306 0.278464003320622 no 942 0.275241532680714 315 4620898
SGTC_886 0866-0150 153 µM 0.595931123036221 0.278834731968585 no 943 0.275610620296099 307 271463
SGTC_2718 lomofungin 53.02 µM 0.595644281117921 0.278930981138392 no 944 0.275706444109509 298 5351222 A RNA synthesis inhibitor.
SGTC_1829 berberine 14.4 µM 0.5954030622874 0.279011934091426 no 945 0.275787039525587 305 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1458 k015-0034 6.33 µM 0.594776662927353 0.279222206841149 no 946 0.275996384525222 314 3598957
SGTC_1755 st041960 45.185 µM 0.594655394530603 0.279262923696771 no 947 0.276036921889885 316 2257073
SGTC_894 0960-0238 55.9 µM 0.59453105257071 0.279304675522121 no 948 0.276078489714727 316 6741907 YDL195W SEC31
SGTC_2009 4012297 12.05 µM 0.594340084831705 0.279368805008413 no 949 0.276142336686311 308 45595307
SGTC_2115 tiliquinol 12.7705 µM 0.592782744028868 0.279892047448928 no 950 0.276663278762361 321 71208 A bioactive hydroxyquinoline.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.592550980556503 0.27996995700305 no 951 0.276740846516117 334 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_755 1995-0008 37.3 µM 0.592120806400702 0.280114592109698 no 952 0.276884847581296 279 689533
SGTC_298 1391-0729 10 µM 0.591508557516238 0.280320507631013 no 953 0.277089861530467 307 3237558
SGTC_585 0kpi-0023 191 µM 0.590667914675392 0.280603357465087 no 954 0.27737147506387 303 64601
SGTC_2592 piperlongumine 83.33 µM 0.59034924664952 0.280710615300889 no 955 0.277478264729895 313 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_252 miconazole 1.30953 nM 0.590329040559505 0.280717416970143 no 956 0.277485036722413 298 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_596 1155-0152 116 µM 0.589963182174679 0.280840584108605 no 957 0.277607666708535 313 280313
SGTC_2564 betulinic acid 100 µM 0.588731185192142 0.281255530986099 no 958 0.278020807349044 319 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1950 st077106 7.18 µM 0.58804958551707 0.281485226566867 no 959 0.278249505343153 290 13831864
SGTC_59 0330-0160 1.33 µM 0.587392903855584 0.281706610469783 no 960 0.278469929283107 318 4293482
SGTC_3187 9109394 49.47 µM 0.587342386932404 0.281723644471499 no 961 0.278486889484144 300 17098090
SGTC_1471 k673-0312 37 µM 0.586092723026382 0.282145181591362 no 962 0.278906603094432 290 24099884
SGTC_3247 9135149 49.47 µM 0.581369467950053 0.283741168701685 no 963 0.280495735252662 314 8934436 YOR116C RPO31
SGTC_626 0214-0009 33 µM 0.579089734771642 0.284513033985025 no 964 0.281264313069618 320 3437874
SGTC_1426 4048-4480 71.7 µM 0.578789700177734 0.284614693440093 no 965 0.281365540892335 303 14224343
SGTC_257 daunorubicin 18.5 µM 0.578403843791123 0.284745457020236 no 966 0.281495749728715 305 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_320 4092-0846 5.34 µM 0.576580243956441 0.285363847788562 no 967 0.282111524091197 312 1359356
SGTC_2606 farnesol 9.78 µM 0.575418813406935 0.285758027147654 no 968 0.282504041722741 321 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2904 7225135 42.03 µM 0.574335539494463 0.286125914096894 no 969 0.282870382023598 342 4446116
SGTC_3356 9151811 4.48 µM 0.574261883061405 0.286150936473463 no 970 0.282895299351153 326 1859254 YPR165W RHO1
SGTC_131 0141-0277 33.849 µM 0.572846873505508 0.286631841610093 no 971 0.283374189224622 334 1547771
SGTC_3098 9119039 49.47 µM 0.57214362973961 0.286870988528338 no 972 0.28361233658159 317 17161528
SGTC_2314 7727897 200 µM 0.571790561004308 0.286991089648193 no 973 0.2837319363661 288 900724
SGTC_3298 9116858 71.43 µM 0.571207941135648 0.287189327761755 no 974 0.283929347930261 351 2506942
SGTC_1902 st060212 70.5 µM 0.57118888927516 0.287195811307269 no 975 0.283935804462782 309 688944
SGTC_3150 9097574 49.47 µM 0.571162835585699 0.287204677759882 no 976 0.283944633976328 320 17217476
SGTC_3123 9126162 49.47 µM 0.570586126897301 0.287400973352019 no 977 0.284140112376254 297 25239884
SGTC_211 3455-0679 143.504 µM 0.569114805371013 0.287902057534582 no 978 0.284639115772783 288 748649
SGTC_814 3342-0569 96 µM 0.568089258927149 0.28825156905679 no 979 0.284987180397987 322 4346283
SGTC_1460 k062-0059 9.15 µM 0.566663286783736 0.288737880040789 no 980 0.285471484276493 301 1373085
SGTC_2442 5158906 48.48 µM 0.565274082129366 0.289212023091979 no 981 0.285943677279889 297 1893835
SGTC_613 3914-0030 117 µM 0.565054990300272 0.289286833718133 no 982 0.286018180842298 293 1145395
SGTC_2905 7799065 20.05 µM 0.564436345026953 0.289498124088827 no 983 0.286228604868154 323 1296806
SGTC_3198 9112019 49.47 µM 0.56308845142895 0.289958730692698 no 984 0.28668732750457 360 45595555
SGTC_484 loperamide 105 µM 0.562568628980663 0.290136457887281 no 985 0.286864329460672 293 3955 An opioid-receptor agonist.
SGTC_3323 9138564 53.9225 µM 0.56105656193053 0.290653723313862 no 986 0.287379489499027 312 43912313 YNL103W MET4
SGTC_355 1311-2252 105 µM 0.560946555052267 0.290691372569629 no 987 0.287416985826181 332 5338538
SGTC_3166 9102297 49.47 µM 0.559462862942916 0.291199380820288 no 988 0.287922934725442 322 25237072
SGTC_2930 9013230 14.89 µM 0.559148650980505 0.291307018479454 no 989 0.288030137035428 311 2995857
SGTC_2852 9023854 51.95 µM 0.558102885244017 0.291665393692287 no 990 0.288387065263337 344 19798528
SGTC_307 1501-1223 22.3 µM 0.558088557467663 0.291670305128773 no 991 0.288391956895901 322 2830329
SGTC_3057 9095946 49.47 µM 0.557739860455653 0.291789847300323 no 992 0.288511017270703 323 24540043
SGTC_2073 5212005 126 µM 0.557602395156916 0.291836980160838 no 993 0.288557960286454 344 691789
SGTC_1128 3448-9350 235 µM 0.557244141161937 0.29195983171929 no 994 0.288680317326834 282 619386
SGTC_350 k064-0020 19.8 µM 0.556741613369198 0.292132197854924 no 995 0.2888519903903 308 2790705
SGTC_3315 9136395 68.55 µM 0.556132978660939 0.292341021861405 no 996 0.289059975916032 348 16876844
SGTC_1143 3454-2408 5.08 µM 0.55548431501107 0.292563656277042 no 997 0.289281717829143 293 X1143
SGTC_2645 abamectin 100 µM 0.555358087767724 0.292606989162197 no 998 0.289324877171893 300 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1177 0983-0204 23.6 µM 0.555315678648802 0.292621548570303 no 999 0.289339378284062 325 766818
SGTC_481 bay k-8644 50 µM 0.554860927103727 0.292777689759283 no 1000 0.289494894679641 339 2303 A calcium channel antagonist.
SGTC_110 0850-0284 111.64 µM 0.554276305961124 0.292978479131655 no 1001 0.289694881666688 299 3906265
SGTC_1931 st074438 57.1 µM 0.553479028631696 0.293252408658301 no 1002 0.289967718462313 329 2787313
SGTC_2425 5628681 7.85 µM 0.552275860785964 0.293666019168722 no 1003 0.290379683266661 329 5714958
SGTC_1413 3910-0535 34.4 µM 0.551839011149698 0.293816260851774 no 1004 0.290529328414305 311 2876951
SGTC_2940 9060638 45.86 µM 0.551806907108772 0.29382730350224 no 1005 0.290540327246306 317 4027022
SGTC_1560 lithocholic acid 53.1 µM 0.550564178577622 0.294254905482863 no 1006 0.290966235237669 318 9903 A bile acid which acts as a detergent.
SGTC_881 0833-0569 170 µM 0.549573143075526 0.294596110000467 no 1007 0.291306091928312 308 5418700
SGTC_1316 1272-0050 65.9 µM 0.547066451164432 0.295459954944758 no 1008 0.292166539927484 324 7340392
SGTC_2560 caryophyllene 100 µM 0.547025551481683 0.295474059265333 no 1009 0.292180588968091 315 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_204 PMA1.184 62.41 µM 0.546122022705774 0.295785721549617 no 1010 0.292491031235394 320 2252213 YGL008C PMA1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.544785653971822 0.296246963871745 no 1011 0.292950473269601 336 6708784 An antioxidant flavonoid
SGTC_2231 micatex 6.853 µM 0.543828126544402 0.296577653361673 no 1012 0.293279875902258 334 20737 An antifungal of unknown mechanism.
SGTC_2133 5320837 200 µM 0.540852166569038 0.297606502013255 no 1013 0.294304741476366 332 2841355
SGTC_2044 5102272 200 µM 0.539945423572079 0.297920304613884 no 1014 0.294617335427802 313 592666
SGTC_1583 clindamycin 39.6 µM 0.539413569943649 0.298104436910563 no 1015 0.294800759864906 345 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_173 1273-0061 2.693 µM 0.539004915329976 0.298245951864545 no 1016 0.294941731470611 327 2847414 YPL266W DIM1
SGTC_1311 1190-0148 100 µM 0.538628991389473 0.298376159365291 no 1017 0.295071439558139 345 1961333
SGTC_1134 3477-0009 42.5 µM 0.535824153162454 0.299348477280028 no 1018 0.296040043870233 367 3973534
SGTC_2385 9074692 200 µM 0.535807796520046 0.299354151643562 no 1019 0.296045696642919 305 17046906
SGTC_3295 9122362 53.5725 µM 0.535749586089731 0.299374346106917 no 1020 0.296065814274374 335 4730473
SGTC_1396 3511-0007 98.6 µM 0.535645387867952 0.299410496277248 no 1021 0.296101826937547 324 X1396
SGTC_1234 0326-0494 15.5 µM 0.535610781889152 0.299422502793571 no 1022 0.296113787792244 355 1547813
SGTC_2897 9048598 12.99 µM 0.535279511093135 0.299537447973603 no 1023 0.296228296041562 324 6467404
SGTC_497 capsazepine 133 µM 0.533140116099993 0.300280261814622 no 1024 0.296968295624498 302 2733484 A calcium channel blocker.
SGTC_799 1310-0557 151 µM 0.531928710316832 0.300701239776534 no 1025 0.297387685820039 351 5354492
SGTC_3267 9137951 49.47 µM 0.531467643315417 0.300861536011286 no 1026 0.297547378841515 346 16643986
SGTC_2438 5259590 200 µM 0.531403219582687 0.300883936869645 no 1027 0.29756969546266 349 1201127
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.531045340991879 0.301008388984517 no 1028 0.297693679849121 328 551469
SGTC_1790 st045711 43.5 µM 0.53085261566794 0.301075418738673 no 1029 0.297760457872834 300 585119
SGTC_1563 conessine 56.1 µM 0.530520244573162 0.301191033011393 no 1030 0.297875638264205 357 441082 An anti-amoebic, histamine inhibitor.
SGTC_2408 sulbentine 18.36 µM 0.53050100308724 0.301197726716049 no 1031 0.297882306860444 297 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.529424157231501 0.301572445307198 no 1032 0.298255621949954 349 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3239 9133757 49.47 µM 0.529380975338487 0.301587476025545 no 1033 0.298270596456511 357 17036923
SGTC_983 1491-0821 12.2 µM 0.527840623742287 0.302123860613197 no 1034 0.298804979389763 304 46495113
SGTC_1384 3089-0840 101 µM 0.525392390169903 0.30297726991931 no 1035 0.29965522126342 308 1069836
SGTC_3321 9137793 26.8275 µM 0.524874427698419 0.303157960307743 no 1036 0.29983524373782 322 4904192
SGTC_2586 curcumin 80 µM 0.521607218748032 0.304298829914195 no 1037 0.300971918077092 323 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1558 st069300 45.6 µM 0.52145161079606 0.304353213987158 no 1038 0.301026103109555 335 24208000
SGTC_1588 farnesol 29.9 µM 0.519545628691777 0.305019694415847 no 1039 0.301690151248249 345 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_918 glabranin 770.725 nM 0.518739869417319 0.30530164567667 no 1040 0.301971077414445 333 124049 Also referred to as licorice root.
SGTC_297 0986-0032 24 µM 0.51857019564449 0.305361032652284 no 1041 0.302030248769331 334 2847425
SGTC_246 cycloheximide 667 µM 0.517385377502704 0.3057758697889 no 1042 0.30244358257193 326 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2270 7924575 90.91 µM 0.517298266493653 0.305806379575047 no 1043 0.30247398198975 343 1262135
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.517129223055604 0.305865589245384 no 1044 0.302532977547506 327 97141
SGTC_2136 5328288 199.296 µM 0.515935914556017 0.306283705394549 no 1045 0.30294958459946 318 262395
SGTC_1428 4049-0204 61.7 µM 0.515867808817968 0.306307576171001 no 1046 0.302973369372079 347 X1428
SGTC_2733 amorolfine 100 µM 0.515578099556362 0.306409127242128 no 1047 0.303074554749588 360 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1621 st003705 32.4 µM 0.515544218679517 0.306421004393472 no 1048 0.303086389149803 333 24207032
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.515266905914208 0.306518225745573 no 1049 0.303183260712332 293 4000243
SGTC_2225 6654152 15.4 µM 0.513974606520715 0.306971464447805 no 1050 0.303634872322307 351 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1892 st058411 7.36 µM 0.513878556225655 0.307005163256785 no 1051 0.303668450391864 332 3934738
SGTC_2570 licareol 100 µM 0.51345037267363 0.307155409339977 no 1052 0.303818158557061 333 443158
SGTC_2489 cantharidin 73.42 µM 0.509811156686229 0.30843368538387 no 1053 0.305091884361838 338 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2078 5212016 200 µM 0.508557212408575 0.308874673370429 no 1054 0.305531313484452 352 1899708
SGTC_3008 9078912 71.4286 µM 0.508114323444906 0.309030494776648 no 1055 0.305686585408189 346 16648731
SGTC_3191 9110352 49.47 µM 0.507623961143404 0.309203058796303 no 1056 0.305858541718585 343 17122424
SGTC_805 3852-0218 479 µM 0.506252177604105 0.30968602841523 no 1057 0.306339815033543 317 6615355
SGTC_1272 0839-0021 27 µM 0.505210641862735 0.310052945930811 no 1058 0.306705448319831 362 5027250
SGTC_180 1486-1293 102.781 µM 0.504736672520475 0.310219980937776 no 1059 0.306871899974252 329 4140536
SGTC_8 0354-0001 70 µM 0.504194113808889 0.310411236098091 no 1060 0.307062488177175 345 4993152
SGTC_3012 9080433 71.4286 µM 0.502944043551689 0.310852088364639 no 1061 0.307501807064489 357 17688859
SGTC_2064 5220758 200 µM 0.502795897478687 0.310904351869685 no 1062 0.307553889154571 318 788518
SGTC_2963 9082507 9 µM 0.501998454129879 0.31118574231546 no 1063 0.307834304191945 342 16459611
SGTC_2727 riluzole 51.77 µM 0.499838398031588 0.311948506251535 no 1064 0.30859443547418 349 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1199 1638-0010 4.46 µM 0.499731341165854 0.311986331435429 no 1065 0.30863213053817 329 3111136
SGTC_2909 7941780 10.49 µM 0.499218961671038 0.312167392097772 no 1066 0.308812568911312 331 1243215
SGTC_2646 retinol 96.75 µM 0.497541509027821 0.312760474494069 no 1067 0.309403619485139 349 445354 A vitamin A analog and teratogen.
SGTC_306 1672-3436 11.6 µM 0.496293201471977 0.313202142684846 no 1068 0.309843781091416 363 6797378
SGTC_721 1187-1332 279 µM 0.494632626762579 0.313790092096729 no 1069 0.31042973355281 338 25730
SGTC_1633 st005664 67.9 µM 0.494620020480254 0.313794557336646 no 1070 0.310434183664318 336 2063822
SGTC_1716 st033144 30.6155 µM 0.492302278245356 0.314615981958048 no 1071 0.311252834907539 373 674617
SGTC_2517 totarol 10 µM 0.491202620371244 0.315006030163319 no 1072 0.311641572901677 316 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1853 st056710 91.2 µM 0.490696339426464 0.315185677223789 no 1073 0.311820617961466 366 269167
SGTC_2869 9037858 32.47 µM 0.489952234331333 0.315449792354995 no 1074 0.31208384969962 328 27187042
SGTC_29 0299-0004 12.984 µM 0.489308255989292 0.315678444306941 no 1075 0.312311738469916 334 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1662 st014054 52 µM 0.488697848460803 0.315895241705837 no 1076 0.31252781362255 342 2838777
SGTC_2036 5160441 105 µM 0.487005047235861 0.316496802256767 no 1077 0.313127377082411 351 134534 YIL048W NEO1
SGTC_1656 st012921 11 µM 0.48670066634032 0.316605019830719 no 1078 0.313235236476761 337 6732821
SGTC_887 0885-0007 9.62 µM 0.486073937780598 0.316827892202008 no 1079 0.313457372226053 342 5719458
SGTC_2923 7992654 58.14 µM 0.486037675388773 0.316840789589482 no 1080 0.313470227028973 310 2985126
SGTC_36 0335-0881 14.2 µM 0.486012894738177 0.316849603412272 no 1081 0.313479011753014 337 23828853
SGTC_2934 9036370 36.88 µM 0.485286411102182 0.317108040626437 no 1082 0.313736596715122 349 6462800
SGTC_3059 1327-0034 3 µM 0.485284103628673 0.317108861622695 no 1083 0.313737415006976 331 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_411 enrofloxacin 100 µM 0.48365194773143 0.317689806021127 no 1084 0.314316450516141 357 71188 A bacterial gyrase inhibitor.
SGTC_281 1672-3440 14.9 µM 0.482485722613739 0.318105183724611 no 1085 0.314730469194747 343 6833000
SGTC_3005 9076496 71.4286 µM 0.481215435331306 0.318557885988098 no 1086 0.315181695854809 342 21368410
SGTC_1059 3448-6867 171 µM 0.479617401441647 0.319127774741874 no 1087 0.315749735236948 341 3934407
SGTC_2256 7954252 200 µM 0.479500237369625 0.319169574485217 no 1088 0.315791399693861 360 2972920
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.476939842415284 0.320083600618587 no 1089 0.316702479829117 357 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_49 0717-0965 32.132 µM 0.476882724330797 0.320104003480874 no 1090 0.316722817198767 365 5889349 YGL099W LSG1
SGTC_1437 4092-1038 11.6 µM 0.476728232652976 0.3201591913979 no 1091 0.316777828022638 349 3977136
SGTC_619 1652-1634 108 µM 0.476406105854039 0.320274275163188 no 1092 0.316892542769356 348 5400454
SGTC_2258 7960471 200 µM 0.475745419702033 0.320510367511568 no 1093 0.317127879246102 356 2974708
SGTC_2000 st075254 36.4 µM 0.474824637666957 0.32083952477202 no 1094 0.317455985288883 331 17234175
SGTC_1465 k213-0056 144 µM 0.474596485058001 0.320921105588812 no 1095 0.31753730603381 323 24048857 YMR208W ERG12
SGTC_927 2425-1185 123 µM 0.47442878248625 0.320981076723417 no 1096 0.317597086105149 363 730375
SGTC_263 alizarin 107.927 µM 0.474422293179075 0.320983397420423 no 1097 0.317599399410625 360 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1629 st005085 44.9 µM 0.474383804618533 0.320997161789647 no 1098 0.317613119942785 338 24207091
SGTC_463 ikarugamyin 104 µM 0.47398784972919 0.321138778384712 no 1099 0.31775428582258 373 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_105 0111-0055 734.78 µM 0.473123460918401 0.321448024678471 no 1100 0.318062549848682 349 5179370
SGTC_851 0394-0702 453 µM 0.472027717478203 0.321840219012621 no 1101 0.31845350229694 358 762646
SGTC_942 3253-1115 227 µM 0.468907604648835 0.322958072984171 no 1102 0.319567840184063 383 46497897
SGTC_1029 k015-0030 64.7 µM 0.468232308230629 0.323200224969951 no 1103 0.319809235108398 336 2208316
SGTC_2120 5538279 151.968 µM 0.467964408282387 0.323296310964108 no 1104 0.319905021153877 333 2058197
SGTC_2841 9004761 38.96 µM 0.464231296356768 0.324636467007048 no 1105 0.321241020506487 313 2991039
SGTC_1743 st037606 46.3785 µM 0.463548767647859 0.324881735470798 no 1106 0.321485533649269 315 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_215 1287-0124 461.5 µM 0.463426934627687 0.324925524472303 no 1107 0.321529187975637 362 5560863
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.46326889635726 0.324982329902607 no 1108 0.321585818777639 344 521171
SGTC_1611 st001856 99.4 µM 0.461435853746298 0.325641497544767 no 1109 0.32224296660154 393 647478
SGTC_1477 0139-0234 16 µM 0.459630489609491 0.326291245294971 no 1110 0.322890735210049 335 620880
SGTC_842 0271-0008 11.1 µM 0.458829801906458 0.326579580548551 no 1111 0.3231781959429 337 1221709
SGTC_554 4483-2211 187 µM 0.458257084319788 0.326785885179674 no 1112 0.323383876266992 352 747107
SGTC_3335 9143315 29.6265 µM 0.457038089989358 0.327225168242915 no 1113 0.323821833927108 328 4899691
SGTC_591 4299-0174 154 µM 0.456127302891969 0.327553540476165 no 1114 0.324149218887682 377 5509088
SGTC_1393 3470-5649 58.2 µM 0.455798397185411 0.327672155884409 no 1115 0.324267478404709 357 4108395
SGTC_1230 0170-0365 3.77 µM 0.455634304747928 0.327731340113384 no 1116 0.324326485204141 344 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.455465917289263 0.327792077953395 no 1117 0.324387041057767 334 6312947
SGTC_825 1988-2224 89.6 µM 0.455438875124587 0.327801832564498 no 1118 0.324396766451027 345 1180859
SGTC_1760 st045453 10.4495 µM 0.454828406821449 0.328022071075813 no 1119 0.324616345985692 374 3323419 YIL048W NEO1
SGTC_336 4111-0029 111 µM 0.453348505853358 0.328556222739419 no 1120 0.32514890498184 369 3131175
SGTC_428 3448-4153 16.5 µM 0.451968386084608 0.329054675567961 no 1121 0.325645878694505 326 3834874
SGTC_2305 7443522 69.23 µM 0.45179765794849 0.329116357980868 no 1122 0.325707378547047 370 5415886
SGTC_570 0987-0065 62.6 µM 0.4517831712736 0.329121592089591 no 1123 0.325712597169302 376 3104428
SGTC_2339 9000433 200 µM 0.451489840685819 0.329227581115773 no 1124 0.325818272762103 340 2988954
SGTC_2706 st078239 82.5 µM 0.449878544139928 0.329810034867458 no 1125 0.326399009596762 353 15434492
SGTC_1746 st038117 42 µM 0.449852633159814 0.329819404582337 no 1126 0.326408351768677 344 2898218
SGTC_667 1498-1044 59 µM 0.447904664248374 0.33052411846703 no 1127 0.327111001026133 374 6739982
SGTC_2411 st077133 39.94 µM 0.446599385128703 0.33099666404024 no 1128 0.3275821698208 390 1403142 YNL221C POP1
SGTC_1936 st074407 74.3 µM 0.446073480200672 0.3311871317063 no 1129 0.327772084288958 348 809813
SGTC_1561 5-methoxyflavone 52.9 µM 0.445954587400612 0.331230197321184 no 1130 0.327815024961489 358 94525
SGTC_2694 st077685 81.9 µM 0.445011512429732 0.331571879078329 no 1131 0.328155717234685 328 2838096
SGTC_781 4335-2806 94.4 µM 0.444411526663299 0.331789330535763 no 1132 0.328372540639446 372 845254
SGTC_2993 9054257 71.4286 µM 0.444211920664792 0.331861685846904 no 1133 0.32844468725875 346 6470217 YGL055W OLE1
SGTC_1067 clotrimazole 1.36 µM 0.442163368748863 0.332604628853934 no 1134 0.329185495732657 338 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3124 9127567 49.47 µM 0.440873114981886 0.333072899760517 no 1135 0.329652429036244 352 17592030
SGTC_346 4513-0042 7.16 µM 0.43986576820446 0.333438676488538 no 1136 0.330017165111472 356 2827372
SGTC_526 4469-0568 170 µM 0.439388719359595 0.333611952539454 no 1137 0.330189949461999 362 2901964
SGTC_2726 cimetidine 79.27 µM 0.436294639928051 0.334736659820001 no 1138 0.331311485155169 377 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1057 3448-5381 134 µM 0.433974133714055 0.335581145596534 no 1139 0.332153612256173 350 5497911
SGTC_2193 5925765 200 µM 0.433400042396912 0.335790199099628 no 1140 0.332362084869829 351 877370
SGTC_1906 st060206 94.7 µM 0.432682663571065 0.336051501718942 no 1141 0.332622663091751 378 5133468
SGTC_2180 6301957 200 µM 0.432258239230485 0.336206134058453 no 1142 0.332776867627134 362 845462
SGTC_316 k060-0003 58.6 µM 0.43179595010775 0.336374593373665 no 1143 0.33294486162578 374 6152314
SGTC_1365 1672-3266 55.4 µM 0.431616972028407 0.336439822258475 no 1144 0.333009910543557 380 6415873
SGTC_108 0509-0257 621.132 µM 0.431596791863915 0.336447177264795 no 1145 0.333017245264619 354 536624
SGTC_1815 st051655 58.2 µM 0.431178181730082 0.336599761002573 no 1146 0.333169408505473 357 5984156
SGTC_1319 1306-0155 43.7 µM 0.430623587932303 0.33680195233258 no 1147 0.333371043603817 360 3122360
SGTC_2502 avocadyne acetate 18.59 µM 0.427613815791539 0.337900063063277 no 1148 0.334466152825213 331 3952079
SGTC_614 0462-0418 107 µM 0.425993420585212 0.33849183430151 no 1149 0.33505632013114 358 5188303
SGTC_2996 9066192 71.4286 µM 0.424732694074383 0.338952530001183 no 1150 0.335515773740138 342 6472854
SGTC_17 0960-0276 49.807 µM 0.424265907611811 0.339123164649753 no 1151 0.335685949797151 361 6821114
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.423779970114534 0.339300835057715 no 1152 0.335863143542707 365 1377
SGTC_3161 9100388 49.47 µM 0.42298823046178 0.339590390596439 no 1153 0.336151924080165 361 25236368
SGTC_214 4373-3496 70 µM 0.41930811556275 0.340937525438855 no 1154 0.337495483109408 374 3779166
SGTC_1762 st045503 25.4615 µM 0.419034346244465 0.341037822195362 no 1155 0.33759551560124 367 4645554
SGTC_3026 9090633 49.47 µM 0.419020590473945 0.341042861987036 no 1156 0.337600542121097 353 25236842
SGTC_735 3076-0345 636 µM 0.418972244816791 0.341060574926859 no 1157 0.337618208421002 354 2888990
SGTC_1657 st012939 43.4 µM 0.418832782311301 0.341111673329414 no 1158 0.337669172323883 362 24207257
SGTC_92 0063-0024 660.874 µM 0.418506540090915 0.341231218316833 no 1159 0.33778840292391 362 3594437
SGTC_2824 7998404 51.95 µM 0.417753845647053 0.341507089039629 no 1160 0.338063549615284 383 837851
SGTC_2790 5423970 71.43 µM 0.41740202472822 0.341636064298719 no 1161 0.338192187079037 364 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_775 4577-0580 57.3 µM 0.417257495850447 0.341689053003941 no 1162 0.338245037133109 381 2006902
SGTC_1468 k284-1086 134 µM 0.417148430701398 0.341729041687416 no 1163 0.338284921231643 365 15996457
SGTC_1214 0358-0031 63.7 µM 0.415124028103001 0.342471609935908 no 1164 0.339025555225441 390 4301366
SGTC_514 4466-0038 2.65 nM 0.414326713523021 0.342764239177871 no 1165 0.339317426301463 342 5722064
SGTC_2851 9015922 71.43 µM 0.41385506139146 0.342937388695477 no 1166 0.339490128295621 396 2996893
SGTC_335 4077-0256 27.6 µM 0.413524744207706 0.3430586719956 no 1167 0.339611098606508 379 3121989
SGTC_1274 0865-0114 173 µM 0.41278421039015 0.343330634203991 no 1168 0.33988236041513 345 870624
SGTC_3214 9129694 49.47 µM 0.412332506573859 0.343496562995237 no 1169 0.340047862857383 409 17158655
SGTC_382 3229-0966 23.2 µM 0.41126193413904 0.343889947281973 no 1170 0.340440239311858 379 5722370
SGTC_2347 9049783 174.81 µM 0.410825194557319 0.344050476814728 no 1171 0.34060035876982 387 6467988 YPL169C MEX67
SGTC_1811 st050069 61.5 µM 0.41064391548164 0.344117116644939 no 1172 0.340666828570987 380 3877702
SGTC_2162 5663267 200 µM 0.410430119743187 0.344195716116653 no 1173 0.340745227652335 394 6456493
SGTC_1794 st048918 76.9 µM 0.409666774811234 0.344476405740747 no 1174 0.341025203008194 381 672303
SGTC_1709 st033179 39.1045 µM 0.409641197074303 0.344485812416519 no 1175 0.341034585783505 364 573381
SGTC_399 oxolinic acid 75 µM 0.40855591272676 0.344885033936673 no 1176 0.341432795150712 363 4628 A DNA gyrase inhibitor.
SGTC_3254 9136651 49.47 µM 0.40719431009602 0.345386143353527 no 1177 0.341932640145061 380 16454030
SGTC_1098 clofazimine 15.1 µM 0.406371547706354 0.345689075351229 no 1178 0.34223481103383 379 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_251 melphalan 456.522 µM 0.405086119973315 0.346162553370701 no 1179 0.342707104373122 397 460612 A DNA alkylator.
SGTC_848 0368-0089 85.6 µM 0.403836388174207 0.346623113718508 no 1180 0.343166518116576 406 762535
SGTC_2511 berberine 10.47 µM 0.403446959411875 0.346766675246155 no 1181 0.343309723395023 359 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1900 st060200 72.8 µM 0.399188408647752 0.348338006881773 no 1182 0.344877191737742 369 688945
SGTC_2395 5646831 180.19 µM 0.398071928092663 0.348750401289075 no 1183 0.34528858313772 391 6808628
SGTC_2016 5121758 140 µM 0.397368359732044 0.349010370181144 no 1184 0.345547922073099 368 2795203
SGTC_2684 capsaicin 100 µM 0.394797514485374 0.349960900819998 no 1185 0.346496164696768 395 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2526 patulin 37.61 µM 0.394557673132024 0.350049626563862 no 1186 0.346584678095646 346 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_841 0251-0215 91.2 µM 0.393433754677063 0.350465512492127 no 1187 0.346999571483255 394 3888614
SGTC_84 0443-0269 128.823 µM 0.392376836681308 0.350856769722025 no 1188 0.347389899144155 392 6150058
SGTC_1956 st077085 54 µM 0.392041782848577 0.350980835318251 no 1189 0.347513670827511 401 24208685
SGTC_1496 4469-0713 57.4 µM 0.391209647034538 0.351289031900071 no 1190 0.347821139055284 399 746691
SGTC_1329 1447-1697 50.6 µM 0.390278800862936 0.351633903557557 no 1191 0.348165198671854 370 2840515
SGTC_891 0929-0073 133 µM 0.390000091967514 0.351737186926125 no 1192 0.348268239461082 411 5603632
SGTC_1658 st012944 20 µM 0.388985402905649 0.352113300706797 no 1193 0.348643472260501 389 24207260
SGTC_3325 9138760 55.175 µM 0.387628893333371 0.352616342762075 no 1194 0.349145341882947 348 43844959
SGTC_1312 1218-2183 165 µM 0.386845374856005 0.352907016850724 no 1195 0.349435341554577 368 6744073
SGTC_1487 3970-0795 2.82 µM 0.386317697703521 0.353102825888611 no 1196 0.349630697539488 366 3765103
SGTC_630 4356-0227 183 µM 0.386237390905361 0.35313262933427 no 1197 0.349660432116353 393 779312
SGTC_31 0508-1974 57.237 µM 0.386131778859422 0.353171825430727 no 1198 0.349699537675547 362 6810525
SGTC_53 0973-0023 39.979 µM 0.385843433430628 0.353278847814152 no 1199 0.349806313059727 388 674768
SGTC_1267 0828-0272 9.49 µM 0.385375335685614 0.353452611832209 no 1200 0.349979676688891 373 745334
SGTC_1261 0712-0010 12.7 µM 0.384973727192 0.353601718518108 no 1201 0.350128440437656 390 2840123
SGTC_254 nsc-64875 3.808 µM 0.384577450398602 0.353748867704577 no 1202 0.350275251764959 383 56993
SGTC_60 0986-0278 202 µM 0.383272297549047 0.354233663615134 no 1203 0.350758938613827 409 3110598
SGTC_2113 5491891 107.031 µM 0.383100698313849 0.354297421336867 no 1204 0.350822550939395 379 789979
SGTC_187 1488-2104 32.728 µM 0.382954710160253 0.354351666472642 no 1205 0.350876672456416 385 2852859
SGTC_1836 st055642 81 µM 0.381068060877036 0.355052958343993 no 1206 0.351576373147501 411 8571
SGTC_2449 5812982 45.77 µM 0.380594483031945 0.355229070571249 no 1207 0.351752087825644 384 776185
SGTC_1831 st055328 12 µM 0.380394217449234 0.355303553838131 no 1208 0.351826403202696 378 1103068
SGTC_1978 st071761 42 µM 0.380259602172357 0.355353623389042 no 1209 0.351876359975926 362 5147680
SGTC_3223 9129970 49.47 µM 0.379164616752308 0.355760991013553 no 1210 0.352282812491026 378 17248386
SGTC_2077 5212015 200 µM 0.378230908920282 0.356108488690379 no 1211 0.352629533002687 393 780900
SGTC_3087 9117406 49.47 µM 0.378112965434449 0.356152392181468 no 1212 0.352673338531385 335 42546093
SGTC_79 0052-0007 94.094 µM 0.37782388270451 0.356260008911239 no 1213 0.352780715349111 399 2801472
SGTC_2948 9070189 9.45 µM 0.377195122362836 0.356494116833181 no 1214 0.353014302421749 381 6473636 YDL196W YDL196W
SGTC_982 1491-0518 27.5 µM 0.376283830954152 0.356833516235955 no 1215 0.35335294927866 366 3091256
SGTC_2468 5987765 72.9 µM 0.375925410270361 0.356967036736901 no 1216 0.353486174556048 367 26772094
SGTC_2303 7774051 200 µM 0.375301195975519 0.35719961370328 no 1217 0.353718238396168 400 2953184
SGTC_295 k015-0027 31 µM 0.373283054935408 0.357951918726553 no 1218 0.354468893361679 383 3887424
SGTC_1228 0124-0032 52.5 µM 0.371960828592383 0.358445106233273 no 1219 0.354961007199126 386 X1228
SGTC_690 glyoxal 20.3 µM 0.371290126896769 0.358695366835263 no 1220 0.35521072542208 381 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_396 dithiazanine 1.25 µM 0.368034321707076 0.35991107407331 no 1221 0.356423821241521 365 10578 An antihelmenthic.
SGTC_1557 sumaresinolic acid 42.3 µM 0.367279790244474 0.360193016619739 no 1222 0.356705163679574 373 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_48 0382-0018 55 µM 0.364983532145133 0.361051516946509 no 1223 0.357561849496713 341 762596
SGTC_513 4245-1575 41.7 µM 0.364035103707305 0.36140630983262 no 1224 0.357915898117892 386 719745
SGTC_1844 rapamycin 4 nM 0.363679771633421 0.361539264960873 no 1225 0.358048575186004 367 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_845 0330-0138 4.51 µM 0.361392342380748 0.36239555538873 no 1226 0.35890308582241 416 9039800
SGTC_301 4119-0100 24.5 µM 0.35835084298849 0.363535195568375 no 1227 0.36004038688284 412 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2816 7982706 58.44 µM 0.357403291815256 0.363890487402537 no 1228 0.360394956383956 370 2981853
SGTC_3279 9140807 49.47 µM 0.356984910877201 0.36404739992554 no 1229 0.360551550936943 397 45595718
SGTC_314 1671-0008 2.74 µM 0.355935454802035 0.364441095551963 no 1230 0.360944451586987 396 3913060
SGTC_2657 nystatin 74.44 µM 0.355037083803746 0.364778226396886 no 1231 0.361280904872553 380 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1821 st053465 65.6 µM 0.353953766864964 0.365184900815404 no 1232 0.361686765887736 363 675086
SGTC_1681 tripelennamine 100 µM 0.351801923138658 0.365993146899835 no 1233 0.36249340809778 346 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1395 3486-0190 4.35 µM 0.351286481216212 0.36618683861298 no 1234 0.362686717964524 404 6748079
SGTC_2173 5763948 167 µM 0.351102944976755 0.366255815721783 no 1235 0.362755559325448 407 2867177
SGTC_256 clotrimazole 625 nM 0.350941466009416 0.366316506778029 no 1236 0.362816131042721 382 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2702 st077768 96.8 µM 0.350665230133756 0.366420336392208 no 1237 0.362919756714082 348 6484119
SGTC_1160 4092-0570 10.5 µM 0.350474717289688 0.366491950729208 no 1238 0.362991230548281 380 4994975
SGTC_1685 st024049 53.0905 µM 0.350085160753725 0.366638400643181 no 1239 0.363137393549884 414 1941139
SGTC_2703 st077852 53.4 µM 0.349903354275144 0.366706755631755 no 1240 0.363205614813011 389 6281836
SGTC_1023 4482-3888 16 µM 0.349627076505261 0.366810637711326 no 1241 0.363309293895519 406 3303168
SGTC_1594 piperine 70.1 µM 0.348379461067649 0.367279869904147 no 1242 0.363777612633205 384 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2549 cedrol 20.94 µM 0.346681769638147 0.367918695495801 no 1243 0.364415203766759 394 6708665 A sedative which affects the nervous system.
SGTC_3025 9087895 49.47 µM 0.34554007101245 0.368348511802701 no 1244 0.364844195431553 394 17173641
SGTC_1741 st038134 10.228 µM 0.34161721808078 0.369826604780191 no 1245 0.366319488907254 401 1272587
SGTC_870 0573-2213 57.6 µM 0.340693181350391 0.370175053840093 no 1246 0.366667286201605 374 3916321
SGTC_2893 9048488 25.97 µM 0.339138315185596 0.370761625564463 no 1247 0.367252767811313 389 6467338
SGTC_984 1492-0255 2.91 µM 0.338425589204886 0.37103060126244 no 1248 0.367521246588921 408 1585198
SGTC_1138 3761-0006 1.03 µM 0.338005102099632 0.37118931848156 no 1249 0.367679671457225 399 12061087
SGTC_1571 st070080 73.4 µM 0.337364768273383 0.371431061207451 no 1250 0.367920970145807 373 4315245
SGTC_1 0258-0098 57.368 µM 0.335777067828565 0.372030678170993 no 1251 0.36851949219763 367 6790032 YDR047W HEM12
SGTC_957 1187-1561 14.1 µM 0.335583336398132 0.372103864799053 no 1252 0.368592545817265 412 1538454
SGTC_2033 5192550 145 µM 0.334256670585377 0.372605168207974 no 1253 0.369092941856455 372 182073
SGTC_2432 5630864 12.22 µM 0.333132733676942 0.373030035986487 no 1254 0.369517045658113 404 5714970
SGTC_101 0490-5701 117.494 µM 0.333074072302279 0.37305221525629 no 1255 0.36953918517322 411 4661669
SGTC_1774 st048371 48.465 µM 0.33259542016084 0.373233204484587 no 1256 0.369719850462612 396 4242727
SGTC_2142 5622915 118.518 µM 0.332383315855588 0.37331341487899 no 1257 0.369799917562746 384 5322196
SGTC_3139 9095020 49.47 µM 0.332343380980847 0.373328517459445 no 1258 0.369814993181169 399 25236292
SGTC_3132 9126706 49.47 µM 0.331496373343793 0.373648884808483 no 1259 0.370134789966739 428 850858
SGTC_1939 st074455 53.6 µM 0.330024096160232 0.374205958267572 no 1260 0.370690877549904 427 1644229
SGTC_1732 st034308 51.822 µM 0.329914818843081 0.374247316605078 no 1261 0.370732163010331 372 830119
SGTC_2109 5483026 200 µM 0.329257045393661 0.374496295592148 no 1262 0.370980704198173 426 759335
SGTC_1361 1608-0041 5.61 µM 0.328637512026235 0.374730847893004 no 1263 0.371214845516592 401 X1361
SGTC_2655 perillic acid 100 µM 0.324382476681822 0.376343031592819 no 1264 0.372824242353232 403 5702197 An apoptosis inducer.
SGTC_63 0099-0242 26.702 µM 0.323456615556214 0.376694116745918 no 1265 0.373174729400122 389 3898502 YLR359W ADE13
SGTC_274 sirtinol 40.1 µM 0.322730605927147 0.376969489882315 no 1266 0.373449635609968 359 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2635 hydroquinidine 100 µM 0.32137119399274 0.377485278721751 no 1267 0.373964555065159 376 442912 An experimental heart treatment.
SGTC_2122 5258151 111.688 µM 0.319993292485957 0.378008305961663 no 1268 0.374486707631985 385 2173356
SGTC_795 0685-0265 78 µM 0.319532396896981 0.378183303811693 no 1269 0.374661414381215 398 302754
SGTC_1018 4259-0013 28.1 µM 0.319137274685534 0.378333348010057 no 1270 0.374811209607811 402 6801262
SGTC_1966 st070145 16.1 µM 0.3166092817166 0.379293764530183 no 1271 0.375770046031732 393 3748532
SGTC_827 3253-0474 693 µM 0.313949780401488 0.380304947355283 no 1272 0.376779590532438 381 5402065
SGTC_3206 9114350 49.47 µM 0.313937798985734 0.380309504728927 no 1273 0.376784140580871 425 17087243
SGTC_304 1310-0298 97 µM 0.31388497287467 0.380329598406072 no 1274 0.37680420196709 427 1550234
SGTC_2364 9055074 200 µM 0.313561151301997 0.38045277875582 no 1275 0.376927184587202 398 6470630
SGTC_2922 7999257 32.47 µM 0.313141932890068 0.380612265662252 no 1276 0.377086416055546 411 2988377
SGTC_163 TUB2.036 7.546 µM 0.312841966219549 0.380726397047976 no 1277 0.377200365041133 408 15992207 YJR013W GPI14
SGTC_1347 1493-0251 600 nM 0.312580153297577 0.380826020171175 no 1278 0.377299829220323 404 3986378
SGTC_1165 k072-0275 30.3 µM 0.312471238366386 0.38086746600556 no 1279 0.377341209003844 390 6153523 YGL055W OLE1
SGTC_770 0389-1121 67.2 µM 0.311748121171837 0.381142671328806 no 1280 0.377615976844374 387 6753108
SGTC_1564 D-Arginine 115 µM 0.308997533385404 0.382190043501453 no 1281 0.378661701573072 411 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2724 maprotiline 69.64 µM 0.308710863464449 0.382299251792509 no 1282 0.37877073968354 425 4011 A tricyclic antidepressant.
SGTC_1457 k015-0032 57.3 µM 0.306571474752613 0.383114557384919 no 1283 0.379584784293757 391 4302660
SGTC_203 k066-0004 30.888 µM 0.306266990497523 0.383230636331069 no 1284 0.379700685072408 413 6795412
SGTC_229 benomyl 22.8748 µM 0.305144086795018 0.383658812991218 no 1285 0.380128207471197 407 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1178 0988-0033 191 µM 0.305054949338483 0.383692808267819 no 1286 0.380162151000545 400 5392207
SGTC_2373 9071805 200 µM 0.304099773590499 0.384057149697366 no 1287 0.380525939662719 420 10149009
SGTC_1581 himbacine 57.9 µM 0.301768624835138 0.384946770805078 no 1288 0.381414225117776 414 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1553 gossypol 38.6 µM 0.301031428073285 0.38522822874686 no 1289 0.381695264635391 447 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1075 aripiprazole 15.2 µM 0.300707990808533 0.385351734529221 no 1290 0.381818587439392 389 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3053 9095903 49.47 µM 0.300053331327675 0.385601754384187 no 1291 0.382068238055212 441 17174018
SGTC_989 1501-0895 10.3 µM 0.299536014122901 0.385799355723615 no 1292 0.382265548681281 436 2830112
SGTC_3178 9107506 49.47 µM 0.296651331309886 0.386901769502896 no 1293 0.383366358582193 413 8897194
SGTC_1600 coumarin 106 71.1 µM 0.296416578414778 0.386991523240459 no 1294 0.383455983082385 443 100336 A hepatotoxic, DNA x-linker.
SGTC_1860 st056228 74.6 µM 0.295982898126993 0.387157349341088 no 1295 0.383621570940005 456 688679
SGTC_1520 flindersine 88 µM 0.295181217344073 0.387463941800142 no 1296 0.383927724733335 423 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2251 lansoprazole 556 µM 0.294479938037628 0.387732194580121 no 1297 0.384195595636809 415 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1699 st031318 29.054 µM 0.29407751898161 0.387886151794171 no 1298 0.384349334496871 435 5340658
SGTC_109 0132-0036 33.701 µM 0.294056727671318 0.387894106598839 no 1299 0.384357278035564 441 67274 A color developer.
SGTC_1117 retinoic acid 1.10837 µM 0.293983665324509 0.387922060799274 no 1300 0.384385192658502 430 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1299 1079-1439 3.74 µM 0.292854213485732 0.388354271327903 no 1301 0.384816793756241 411 323161
SGTC_612 0302-0167 22.4 µM 0.292742078647297 0.38839718983864 no 1302 0.384859652005911 421 235821
SGTC_2710 st078562 53.7235 µM 0.289673888285679 0.389572036685979 no 1303 0.386032867180087 438 17250908
SGTC_955 1216-0110 33 µM 0.289614852174367 0.389594652257023 no 1304 0.386055451680507 413 3619719
SGTC_700 3453-2283 142 µM 0.289229136291082 0.389742421609946 no 1305 0.386203018333812 397 565664
SGTC_2756 carbadox 75.1 µM 0.288407588560123 0.390057213054244 no 1306 0.386517379789231 395 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1243 0416-0003 5.65 µM 0.287385865756039 0.390448805928542 no 1307 0.386908441223777 414 2141977
SGTC_838 0109-0203 71.4 µM 0.287115956549558 0.390552271861144 no 1308 0.387011767380071 401 759422
SGTC_2418 pentamidine 31.67 µM 0.285360960904813 0.391225213713338 no 1309 0.387683806649603 422 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1333 1482-0047 286 µM 0.285176035341455 0.391296141243002 no 1310 0.387754639706097 446 3811116
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.284973399191281 0.391373865754746 no 1311 0.387832260835416 449 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1683 st010134 710 nM 0.284356045122067 0.391610689041319 no 1312 0.388068770049083 408 3818134
SGTC_1763 st044482 94.5 µM 0.282076643033202 0.392485438194654 no 1313 0.388942371236951 437 88505
SGTC_2831 7999036 19.48 µM 0.279617217321482 0.393429883147411 no 1314 0.389885598153882 453 2988270
SGTC_1915 st067105 30.6 µM 0.278683209621354 0.393788716462937 no 1315 0.390243974505202 441 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_593 1203-0218 61.7 µM 0.278352666420876 0.393915728383035 no 1316 0.390370825446291 435 3666956
SGTC_2755 lomerizine 42.69 µM 0.277992152934411 0.39405426931439 no 1317 0.39050919124362 402 3949 A calcium channel blocker.
SGTC_913 3487-1245 167 µM 0.277743367630557 0.394149882288926 no 1318 0.390604683628929 406 4016153
SGTC_2689 tacrolimus 100 µM 0.277630050484514 0.394193434361334 no 1319 0.39064818084779 439 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1172 0370-0043 85 µM 0.275021452756238 0.39519638202518 no 1320 0.391649878339403 393 376585
SGTC_2848 9016370 25.97 µM 0.274865055430147 0.395256535449163 no 1321 0.391709957575987 432 7894410
SGTC_3080 9117754 49.47 µM 0.273838348532455 0.395651488612009 no 1322 0.392104425871414 425 9550191
SGTC_2728 chlorpromazine 9.18 µM 0.273529536218171 0.395770303383891 no 1323 0.39222309553635 460 2726 A thorazine and dopamine antagonist.
SGTC_693 4161-2696 114 µM 0.273043102480022 0.395957477199119 no 1324 0.392410041468605 429 805759
SGTC_1689 st020265 53.493 µM 0.272454711341839 0.396183915046176 no 1325 0.392636204789719 434 5758320 YPR016C TIF6
SGTC_2291 7917025 104.35 µM 0.271616360916148 0.396506608317269 no 1326 0.392958509033327 414 2964612
SGTC_1036 k216-0215 33.5 µM 0.270656330851177 0.396876224928011 no 1327 0.393327683216519 419 622330
SGTC_1539 benzyladenosine 56 µM 0.269817508745198 0.397199251704539 no 1328 0.393650326102745 382 92208 A nucleotide analog.
SGTC_2168 5727979 200 µM 0.269377770748507 0.397368621104147 no 1329 0.393819495252946 405 695210
SGTC_2 0422-0095 29 µM 0.269314184620737 0.397393113526801 no 1330 0.393843958776376 384 6790840
SGTC_1325 1431-0015 227 µM 0.267770028699916 0.397988023213074 no 1331 0.394438171070816 401 1103340
SGTC_901 1112-0062 60.1 µM 0.267277474740767 0.398177837135218 no 1332 0.394627764322135 407 1908457
SGTC_871 0574-0004 149 µM 0.266896106486629 0.39832482033785 no 1333 0.394774577259123 417 9551173
SGTC_2648 atorvastatin 78.68 µM 0.266739403417776 0.398385219476882 no 1334 0.394834906586426 444 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1197 1601-0112 267 µM 0.266075507426464 0.398641136452443 no 1335 0.39509052876291 435 7350313
SGTC_2867 9039098 71.43 µM 0.264932987667436 0.399081654126526 no 1336 0.395530542778791 425 6463460
SGTC_1627 st003713 25.6 µM 0.26447124779533 0.399259722194295 no 1337 0.395708408615206 407 16195070 YER133W GLC7
SGTC_1181 1222-0449 220 µM 0.26394359796713 0.39946323382629 no 1338 0.395911690077885 419 658318
SGTC_451 chloral hydrate 100 µM 0.262015845614164 0.400206989144608 no 1339 0.396654612906628 442 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2932 9016711 44.54 µM 0.260882104556105 0.400644572451564 no 1340 0.397091712795645 417 7117328
SGTC_2639 lactacystin 53 µM 0.260099740041868 0.40094660980016 no 1341 0.397393419221693 401 3870 A proteasome inhibitor.
SGTC_1002 4049-0206 172 µM 0.259646947565137 0.401121440600387 no 1342 0.397568059497788 416 4662749
SGTC_322 k048-0136 19.3 µM 0.258212113333472 0.401675584896541 no 1343 0.398121604879599 421 6823282
SGTC_582 0987-0078 156 µM 0.258170728470872 0.401691570996497 no 1344 0.39813757381405 450 1625765
SGTC_1602 st001878 87.6 µM 0.257950359190293 0.401776697773443 no 1345 0.398222609289701 456 595405 YLR310C CDC25
SGTC_1669 st015249 58.4 µM 0.254490093289155 0.403113977693514 no 1346 0.399558478314052 441 722793
SGTC_2274 7947094 46.08 µM 0.254002586120586 0.403302474807504 no 1347 0.399746780087156 409 2971028
SGTC_2978 9011784 42.97 µM 0.253477735412003 0.403505436106093 no 1348 0.39994953203073 420 2994934
SGTC_104 0074-0074 590.992 µM 0.253447599826444 0.403517090414369 no 1349 0.399961174348257 420 3943124
SGTC_638 3970-0837 4.09 µM 0.253160378547264 0.403628171543211 no 1350 0.400072141356533 413 4118451 YLR208W SEC13
SGTC_1304 1165-0502 251 µM 0.253137496117737 0.403637021521788 no 1351 0.400080982255999 408 767425
SGTC_483 fpl-64176 144 µM 0.25247608146242 0.403892850697364 no 1352 0.400336549809466 447 3423
SGTC_2594 a-mangostin 100 µM 0.251943115888987 0.404099026855791 no 1353 0.400542516291459 452 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_972 1319-0219 195 µM 0.251410612376332 0.404305050875595 no 1354 0.400748331830863 456 23903702
SGTC_2876 9059903 25.97 µM 0.250763226868583 0.404555558139799 no 1355 0.400998587002974 438 6916095
SGTC_1034 k072-0165 12.7 µM 0.249400394256698 0.405083037029292 no 1356 0.401525540104843 449 5835461
SGTC_3046 9092212 49.47 µM 0.24921877062919 0.405153346770682 no 1357 0.401595780276746 444 25236637
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.248214175101606 0.405542298830934 no 1358 0.401984349667088 455 140250 A respiratory chain inhibitor.
SGTC_362 0310-0100 9.03 µM 0.246924779313068 0.406041654465259 no 1359 0.402483219439918 399 790235
SGTC_365 0121-0052 13.6 µM 0.246905463744001 0.406049136139756 no 1360 0.40249069388131 408 3101739
SGTC_158 k038-0087 26.446 µM 0.24580379792827 0.406475911052014 no 1361 0.402917058464114 422 X158
SGTC_1097 itavastatin 7.23 µM 0.245510619391265 0.406589504384463 no 1362 0.403030543330941 447 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_458 nppb 133 µM 0.243744872361687 0.407273816867125 no 1363 0.403714209063905 409 4549 A chloride channel blocker.
SGTC_2880 9042983 58.44 µM 0.243154507969596 0.407502674913929 no 1364 0.403942853367659 433 6464714
SGTC_2544 sphondin 68.51 µM 0.242900914452409 0.407600991553082 no 1365 0.404041078576261 433 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_313 3474-0040 5.03 µM 0.242387954950627 0.407799880568026 no 1366 0.404239783353908 449 1043375 YIL048W NEO1
SGTC_1282 0886-0010 32.4 µM 0.242182338837388 0.40787961046857 no 1367 0.404319439669198 459 2836211 YNL267W PIK1
SGTC_1469 k284-2957 126 µM 0.241958319287365 0.407966480845794 no 1368 0.404406230047604 435 23884841
SGTC_302 1094-0063 18.9 µM 0.241718350765985 0.408059540939537 no 1369 0.404499204646734 438 5440289
SGTC_1064 honokiol 6.76 µM 0.240852802558912 0.40839524467608 no 1370 0.404834601727037 432 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_682 0kpi-0099 17 µM 0.239439065214292 0.408943708612616 no 1371 0.405382570569927 456 1714895 YML126C ERG13
SGTC_2541 muurolladie-3-one 83.07 µM 0.23902684216996 0.409103665493789 no 1372 0.405542384440581 455 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_40 0327-0103 19.753 µM 0.239025437217752 0.409104210690018 no 1373 0.40554292915044 424 409036
SGTC_975 1335-0046 28.5 µM 0.238140246614437 0.409447746668221 no 1374 0.405886160099882 434 16486740
SGTC_1643 st009866 20.2 µM 0.236507145270365 0.41008172364161 no 1375 0.406519581705903 438 3156273 YOR207C RET1
SGTC_1785 bathophenanthroline 24 µM 0.236452835970628 0.410102810793939 no 1376 0.406540650553912 412 72812 An iron chelator.
SGTC_2359 9039622 200 µM 0.236084074708399 0.410245999864239 no 1377 0.406683715617767 441 6463596
SGTC_1213 1315-0166 115 µM 0.234450691989789 0.410880381906405 no 1378 0.407317554264615 405 768401
SGTC_2575 plumbagin 510 nM 0.233786781237998 0.411138301909404 no 1379 0.40757525613832 443 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1747 st037496 66.6 µM 0.233472588988755 0.411260374584564 no 1380 0.4076972261374 410 723305
SGTC_639 0833-0042 114 µM 0.233371455029099 0.411299669849047 no 1381 0.407736488427449 452 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1474 0330-0125 5.35 µM 0.229892489245084 0.412651949703385 no 1382 0.409087656375877 452 X1474
SGTC_3251 9135047 49.47 µM 0.229345949520952 0.412864485309449 no 1383 0.40930002126182 445 17682963
SGTC_22 0964-0034 14.468 µM 0.228791299603396 0.413080200883254 no 1384 0.409515564681528 458 138402
SGTC_541 4513-1321 94 µM 0.228047147514557 0.413369659244887 no 1385 0.409804793810705 417 747515
SGTC_1875 nocodazole 6 µM 0.226150020131073 0.414107811673582 no 1386 0.410542370861806 449 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3020 9089140 49.47 µM 0.225901555749091 0.414204509101812 no 1387 0.410638993893791 415 17217859
SGTC_1123 mangostin 811.285 nM 0.223413215455924 0.41517320790646 no 1388 0.411606959900533 448 5281650 An antioxidant.
SGTC_496 calpeptin 138 µM 0.223314867148269 0.415211505062065 no 1389 0.4116452285518 416 73364 A calpain inhibitor.
SGTC_1281 0884-0031 11.8 µM 0.220730122005503 0.416218301099753 no 1390 0.412651287956559 425 1548255
SGTC_1159 4092-0538 61.2 µM 0.218905852677964 0.41692921216818 no 1391 0.413361693630369 432 717301
SGTC_673 1082-0474 110 µM 0.217685051814737 0.417405105698449 no 1392 0.41383725565914 459 3098046
SGTC_2250 alverine citrate 130 µM 0.217292360710487 0.417558210603163 no 1393 0.413990255074551 448 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.217202793930439 0.417593133220235 no 1394 0.414025153709121 427 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1363 1636-0063 10.4 µM 0.216529407560847 0.417855711340919 no 1395 0.414287552450717 467 6072185
SGTC_312 4092-0653 6.84 µM 0.214648165870556 0.418589470415016 no 1396 0.415020819071643 438 1148278
SGTC_1781 st038725 66.3 µM 0.214281185300166 0.418732640540131 no 1397 0.415163894622417 409 4270275 YIL048W NEO1
SGTC_768 0384-0033 77.3 µM 0.212789275534687 0.419314789921548 no 1398 0.415745664535374 434 3965305 YMR134W ERG29
SGTC_1817 st052116 64.4 µM 0.21154114803985 0.419801950230606 no 1399 0.416232513562586 427 4361398
SGTC_2589 lobaric acid 100 µM 0.211272176951305 0.419906949251016 no 1400 0.416337446239445 420 73157 A novel microtubule depolymerizer.
SGTC_2812 7970281 58.44 µM 0.209941569649925 0.420426465993861 no 1401 0.41685663862696 448 2233435
SGTC_1410 3909-8106 77.9 µM 0.209134612893033 0.420741598408515 no 1402 0.417171577452971 463 1039210
SGTC_2749 bexarotene 57.39 µM 0.208999372159027 0.420794417538834 no 1403 0.417224364369534 437 82146 An retinoic acid receptor inhibitor.
SGTC_1294 1000-1494 117 µM 0.208832825763401 0.420859465253855 no 1404 0.417289372504832 439 712797 YDL207W GLE1
SGTC_523 1934-0222 13.7 µM 0.208329834342596 0.421055930784493 no 1405 0.417485719108785 477 1361595
SGTC_1114 scopoletin 1.73284 µM 0.207614255212285 0.421335465710235 no 1406 0.417765086421222 474 5280460 A coumarin with genotoxic properties.
SGTC_2040 5100729 123 µM 0.205996903661678 0.421967416281413 no 1407 0.418396664979614 464 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_55 0767-0285 6.563 µM 0.205907186771199 0.42200247741578 no 1408 0.418431705755021 464 3116166
SGTC_413 propylparaben 100 µM 0.205843742934826 0.422027271480076 no 1409 0.418456485439943 437 7175 A pharmaceutical preservative.
SGTC_646 4092-0839 27.3 µM 0.204899460253433 0.422396336800947 no 1410 0.418825338463955 467 877796
SGTC_951 1171-0579 82.7 µM 0.204284131712973 0.422636869722366 no 1411 0.419065734782215 450 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1917 st066507 28.5 µM 0.20302491724055 0.42312918852676 no 1412 0.419557778313964 442 3156428
SGTC_2643 anethole 100 µM 0.201727387077418 0.42363661332321 no 1413 0.420064925468911 478 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3158 9100007 49.47 µM 0.198357073354676 0.424955230821112 no 1414 0.421382850295315 437 19297233
SGTC_1164 k060-0068 93.7 µM 0.195633964650113 0.426021247103638 no 1415 0.422448336991332 455 5963676
SGTC_235 0330-0087 5 mM 0.195291447163378 0.4261553709918 no 1416 0.422582396170756 449 46494818 YHR062C RPP1
SGTC_1827 berberine 7.24 µM 0.195251367483149 0.426171066055764 no 1417 0.422598083690632 461 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_600 1495-0418 41.6 µM 0.194989216500213 0.426273726355478 no 1418 0.422700694790055 443 5377768
SGTC_64 000l-0018 272.079 µM 0.194812178296164 0.426343058676488 no 1419 0.422769994025666 435 6811119
SGTC_1419 3993-2473 62.6 µM 0.192008971464022 0.427441162355317 no 1420 0.423867588984865 462 704026
SGTC_2822 7994718 71.43 µM 0.189151072562269 0.428561269554613 no 1421 0.424987206890651 490 1018011
SGTC_868 0527-0199 213 µM 0.1876279202512 0.42915848019991 no 1422 0.42558416887141 471 2849450
SGTC_2907 7721985 69.9 µM 0.187370211893023 0.429259540787614 no 1423 0.425685188219639 442 3267881
SGTC_2304 7443016 91.4 µM 0.186476575500529 0.429610017059506 no 1424 0.426035523356337 478 939854
SGTC_1688 st021091 57.6 µM 0.186472479012635 0.429611623793711 no 1425 0.426037129450246 474 3656366
SGTC_774 k060-0086 136 µM 0.186202223579376 0.429717626595694 no 1426 0.426143090144932 469 5911235
SGTC_854 0422-0053 192 µM 0.186160408530675 0.42973402824452 no 1427 0.426159485302434 469 3596728
SGTC_1509 1326-1131 80 µM 0.185728652941995 0.429903388320865 no 1428 0.426328778724765 460 768313
SGTC_2817 7995342 71.43 µM 0.185144988277774 0.430132356620132 no 1429 0.426557657994625 450 18879975
SGTC_1436 4092-1007 8.32 µM 0.184886223047829 0.43023387625776 no 1430 0.426659138557306 443 2881121
SGTC_733 4069-0007 56.1 µM 0.181556250804179 0.43154071130152 no 1431 0.427965492462434 480 5717425 YNL287W SEC21
SGTC_621 3584-0052 32.1 µM 0.180315199278577 0.432027949820305 no 1432 0.428452561970624 479 2273927
SGTC_321 4534-3890 65.3 µM 0.179555856229502 0.432326119974947 no 1433 0.428750631475404 477 699746
SGTC_2080 5212524 12.4 µM 0.179264135809183 0.43244067967545 no 1434 0.428865153065954 463 260183
SGTC_2139 5578692 56.4705 µM 0.179143427473757 0.432488083952246 no 1435 0.428912541664051 466 650991 YMR113W FOL3
SGTC_1443 4112-3303 14 µM 0.178602956473148 0.432700348284532 no 1436 0.429124736444456 476 704433
SGTC_1572 epiandrosterone 68.9 µM 0.178426647045619 0.432769596172297 no 1437 0.42919396187307 451 441302 A steroid.
SGTC_457 grayanotoxin iii 135 µM 0.17617483845155 0.433654205009534 no 1438 0.430078293801991 475 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1482 3346-2049 8.48 µM 0.175425737307402 0.433948558590025 no 1439 0.430372559350779 465 3826804
SGTC_226 1,3-diallylurea 8.28947 mM 0.173526409361666 0.434695048837656 no 1440 0.431118835541691 445 74537 YKL182W FAS1
SGTC_2734 clemastine 41.6 µM 0.170471613297886 0.435896158504652 no 1441 0.432319628449406 481 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3174 9107204 49.47 µM 0.169811417928898 0.436155817621126 no 1442 0.432579223569361 438 3938802
SGTC_3255 9139072 49.47 µM 0.169749557474975 0.436180149150257 no 1443 0.432603549183252 460 17646060
SGTC_572 0960-0087 17.7 µM 0.169078396486426 0.43644415193913 no 1444 0.432867488689076 475 6796365
SGTC_2666 tannic acid 100 µM 0.168659957040492 0.436608760438056 no 1445 0.433032058563184 473 16134267 A thiamine antagonist.
SGTC_1899 st063254 59.6 µM 0.168539852352262 0.436656010049937 no 1446 0.433079297206249 480 3093813
SGTC_922 1866-0035 480 µM 0.166993738248775 0.437264337307405 no 1447 0.433687487948295 476 3156169
SGTC_224 benfluorex 43.875 µM 0.16694563699823 0.437283265400767 no 1448 0.433706411934032 483 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1637 st007924 17.4 µM 0.166935236266363 0.437287358161964 no 1449 0.433710503808162 470 683336
SGTC_3072 9116419 49.47 µM 0.166088793345775 0.437620461867223 no 1450 0.434043536640799 445 17170162
SGTC_1619 st003326 88.7 µM 0.165785925080144 0.437739661450295 no 1451 0.434162711498084 459 2849032
SGTC_233 rapamycin 362 pM 0.163979077877997 0.438450897667945 no 1452 0.434873807143385 475 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_917 harmaline 728.087 nM 0.163040601297738 0.438820392417118 no 1453 0.435243233567795 447 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_905 2-aminofluorene 215 µM 0.162472718455655 0.439044003804691 no 1454 0.4354668051681 488 1539 An established DNA mutagen. YPR165W RHO1
SGTC_231 b-estradiol 524 µM 0.162267407089009 0.439124852665563 no 1455 0.435547639933268 478 450 A steroid.
SGTC_767 0929-0023 86 µM 0.16177950806528 0.439316990935851 no 1456 0.435739745322289 461 1204563
SGTC_538 2922-0838 53.3 µM 0.160596218400174 0.439783038519029 no 1457 0.436205716758581 446 777039
SGTC_3349 9149703 23.001 µM 0.160309666684791 0.4398959116562 no 1458 0.436318572222247 461 4910494
SGTC_2813 7971799 71.43 µM 0.159882752192462 0.440064082953594 no 1459 0.436486717743479 468 2234054
SGTC_3000 9075062 71.4286 µM 0.159289258452874 0.440297891552979 no 1460 0.436720491611385 479 17057871
SGTC_2868 9035608 32.47 µM 0.158551607180463 0.440588520444592 no 1461 0.437011079122796 489 6462614
SGTC_168 3970-0862 530.542 µM 0.15845565143581 0.440626328621106 no 1462 0.437048882062069 463 3135186
SGTC_3210 9128157 49.47 µM 0.158416827038974 0.440641626239964 no 1463 0.437064177571426 437 17590849
SGTC_953 1188-0045 9.7 µM 0.157474376880512 0.441012998301945 no 1464 0.437435500109498 478 6144426
SGTC_3171 9103192 49.47 µM 0.156237216817101 0.441500579368187 no 1465 0.437923021074459 485 13018434
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.15557432532015 0.441761870163091 no 1466 0.438184281959156 469 688664
SGTC_2598 perillyl alcohol 100 µM 0.155571642083021 0.441762927861608 no 1467 0.438185339539855 464 10819 An apoptosis inducer.
SGTC_1587 estradiol valerate 56.1 µM 0.152403757776399 0.443011955845038 no 1468 0.439434246711964 483 13791 A steroid.
SGTC_2138 5575593 77.673 µM 0.151691973404453 0.443292675352081 no 1469 0.439714944102376 480 762213
SGTC_549 1661-1316 519 µM 0.150470078765881 0.443774642731259 no 1470 0.440196877817121 481 2857282
SGTC_1314 1222-0010 41.1 µM 0.150182476505757 0.443888097452722 no 1471 0.440310325405394 466 3526027
SGTC_558 k064-0027 21.3 µM 0.149948567684486 0.443980374320086 no 1472 0.440402596693423 454 5088526
SGTC_1342 1486-1464 234 µM 0.146922880049678 0.445174277952388 no 1473 0.441596446115235 482 3253938
SGTC_611 3453-1652 23.7 µM 0.144087526316397 0.446293529620864 no 1474 0.442715677246791 477 1560575
SGTC_1650 st011916 45.8 µM 0.14191604915159 0.447151006920721 no 1475 0.443573158618417 492 242528
SGTC_1989 st071868 50.2 µM 0.141749692869623 0.447216708267309 no 1476 0.443638860985225 498 16414057
SGTC_2671 danthron 100 µM 0.140908895495826 0.44754879792259 no 1477 0.443970957339102 467 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2483 5729050 27.16 µM 0.140877099280831 0.447561357193527 no 1478 0.443983516913887 502 2865180
SGTC_2181 6316240 54.2555 µM 0.140654525628156 0.447649273619879 no 1479 0.444071435570286 450 12779990
SGTC_2446 5162541 200 µM 0.139414377628279 0.448139178122947 no 1480 0.444561355802456 462 1549321
SGTC_248 streptozotocin 5.23457 mM 0.139063894219702 0.448277646451889 no 1481 0.444699829591953 492 5300 DNA alkylating agent.
SGTC_855 0428-0020 25 µM 0.138407849401991 0.448536852335453 no 1482 0.444959046899303 461 6812414
SGTC_2428 5615643 7.78 µM 0.138171556247753 0.448630218076088 no 1483 0.445052417138536 498 2253075
SGTC_2147 5545932 89.7195 µM 0.137736328830428 0.448802195503597 no 1484 0.445224403384252 487 797404
SGTC_2307 7538926 6.34 µM 0.137171872508495 0.449025251259598 no 1485 0.445447471604414 488 96582
SGTC_568 1193-0097 7.48 µM 0.136477987000241 0.449299475513984 no 1486 0.445721712771087 460 3646150
SGTC_2798 7813637 45.45 µM 0.135781544197731 0.449574734765784 no 1487 0.445996990760855 498 956368
SGTC_2357 9067248 200 µM 0.135352691072855 0.449744245029982 no 1488 0.446166513442288 481 9150235
SGTC_857 0438-0306 1.35 µM 0.134366924840688 0.450133917794604 no 1489 0.446556217288739 461 4686136
SGTC_3010 9080089 71.4286 µM 0.133261363709839 0.450571002590652 no 1490 0.446993341154215 463 17027233
SGTC_2805 7950783 58.44 µM 0.132359736192944 0.450927506419682 no 1491 0.447349880141371 462 1178958 YDL195W SEC31
SGTC_2141 5621638 7.665 µM 0.132279479387669 0.45095924191108 no 1492 0.447381618905803 495 2856238
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.132056700426813 0.451047335768948 no 1493 0.447469721971983 475 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_141 0443-0274 32.331 µM 0.132030503881707 0.451057694871207 no 1494 0.447480082168922 476 1627241
SGTC_2135 5326629 150.42 µM 0.130163205768773 0.451796180442853 no 1495 0.448218652207894 463 5020077
SGTC_1040 k898-0338 155 µM 0.129246868860662 0.452158637740993 no 1496 0.44858115560106 485 20969351
SGTC_1210 3013-0140 750 nM 0.128923311673976 0.452286630410545 no 1497 0.448709165277145 492 905973
SGTC_3310 9130229 44.1445 µM 0.128428657361223 0.45248231521842 no 1498 0.448904876821515 490 7761258
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.128350205170897 0.452513351897112 no 1499 0.448935917822479 475 279621
SGTC_1996 st072960 66.8 µM 0.127631339699971 0.452797757655557 no 1500 0.449220364229874 477 1719405
SGTC_1102 cgs 12066b 26.1 µM 0.127570915055365 0.452821664648148 no 1501 0.449244274724967 469 6438352 A 5-HT1B full agonist.
SGTC_528 3492-0019 172 µM 0.127282321904281 0.452935848799636 no 1502 0.449358475788077 478 2869262
SGTC_227 fluconazole 33.516 µM 0.126662607648516 0.45318105676129 no 1503 0.449603721089918 488 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1670 st016595 4.04 µM 0.12607952433646 0.453411786927921 no 1504 0.449834487666389 498 597879
SGTC_1864 st057645 30.4 µM 0.126029314424222 0.453431656079819 no 1505 0.449854360011464 494 688666
SGTC_70 0141-0289 43.283 µM 0.125638210368618 0.453586428428791 no 1506 0.450009157547522 466 352408
SGTC_2761 levamisole 97.89 µM 0.12490746055788 0.453875628309031 no 1507 0.450298405980417 486 26879 An alkaline phosphatase inhibitor.
SGTC_2086 5274770 176.623 µM 0.123909110916712 0.454270772391996 no 1508 0.450693619538405 486 689278
SGTC_2992 9074591 71.4286 µM 0.123055835983064 0.454608532189453 no 1509 0.451031441591133 494 17741321
SGTC_2580 diallyl disulphide 81.36 µM 0.122677598152876 0.454758264121292 no 1510 0.451181201967222 494 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_245 methotrexate 289.6 µM 0.122585082839067 0.454794888874185 no 1511 0.451217833756726 501 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1955 wogonin 32.4 µM 0.120228591235988 0.455727900138386 no 1512 0.452151034756834 466 5281703 A flavanone.
SGTC_85 0868-0259 160.055 µM 0.120163327620466 0.455753743614258 no 1513 0.452176883775142 491 83173
SGTC_1124 fisetin 1.16336 µM 0.119644177867596 0.455959326289686 no 1514 0.452382511090897 469 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1719 st032227 49.2 µM 0.119535450308664 0.45600238376698 no 1515 0.452425578041625 498 3125804
SGTC_127 0180-0333 59.125 µM 0.118574760929598 0.456382851208383 no 1516 0.452806131057506 481 771601
SGTC_102 gallobenzophenone 83.616 µM 0.118106172961307 0.456568443378562 no 1517 0.452991766186419 490 70837
SGTC_560 2332-1943 155 µM 0.117613401982862 0.456763623858059 no 1518 0.453186992703686 510 21177716
SGTC_2699 st077704 54.6 µM 0.116304459510321 0.45728213028461 no 1519 0.453705625710952 466 645852
SGTC_377 3970-0964 33.1 µM 0.115656139446251 0.45753897384324 no 1520 0.453962534273807 493 16481235
SGTC_2207 7258803 200 µM 0.114086730677614 0.458160796343075 no 1521 0.454584520463332 494 3666799
SGTC_1697 st025554 27.742 µM 0.112805437191406 0.458668539399325 no 1522 0.455092403803088 500 1269519
SGTC_601 0986-0029 62.9 µM 0.112338501099922 0.4588535907553 no 1523 0.455277507766744 499 24747981
SGTC_1453 4237-0541 195 µM 0.11157218313517 0.459157309392815 no 1524 0.455581314460855 476 739892
SGTC_1878 temozolomide 1 mM 0.110625329497943 0.459532613545584 no 1525 0.455956730365396 501 5394 DNA alkylating agent.
SGTC_2379 9035213 200 µM 0.109627395518439 0.459928203430685 no 1526 0.456352441560254 511 646551
SGTC_285 1486-1325 46 µM 0.108000846696351 0.460573066670285 no 1527 0.456997510286543 483 22310230
SGTC_2102 5377816 72.7585 µM 0.107253390615795 0.460869438767126 no 1528 0.457293980037805 511 1379702
SGTC_590 k048-0076 22.4 µM 0.106638913751803 0.461113099867022 no 1529 0.457537722939858 488 6832814
SGTC_2556 citropten 84.59 µM 0.105925704216915 0.461395930149602 no 1530 0.457820649889628 464 2775 A potential DNA crosslinker.
SGTC_3106 9121286 49.47 µM 0.105620128689853 0.461517115125272 no 1531 0.457941876848338 460 15943471
SGTC_1545 lovastatin 49.4 µM 0.10558868182444 0.461529586508958 no 1532 0.457954352571774 500 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.105465119762899 0.461578589847612 no 1533 0.458003372997128 511 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2629 bisabolol 100 µM 0.105252016583136 0.461663105567489 no 1534 0.458087918316239 508 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_754 3474-0146 171 µM 0.104799884717338 0.461842424669671 no 1535 0.458267300764489 504 24762078
SGTC_1874 staurosporine 7.6 µM 0.104396818281175 0.462002290572351 no 1536 0.458427223765368 512 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.103871303332411 0.462210731734247 no 1537 0.45863574025827 480 2724 A muscle relaxant with antifungal properties.
SGTC_3122 9126309 49.47 µM 0.103751946525782 0.462258075073662 no 1538 0.458683100847 520 17591206
SGTC_1162 k048-0130 20.1 µM 0.103634918825387 0.462304495083247 no 1539 0.458729537819568 485 6797406
SGTC_723 4182-0001 115 µM 0.102222745140524 0.462864685802671 no 1540 0.459289937155304 490 744821 YLR208W SEC13
SGTC_1320 1313-0481 95.3 µM 0.101946692916739 0.462974200728684 no 1541 0.459399493708464 496 6813365 YLR208W SEC13
SGTC_704 1310-0270 142 µM 0.100184599119852 0.463673321090682 no 1542 0.46009888630884 509 5718033
SGTC_3115 9123671 49.47 µM 0.0995531759912214 0.463923869091835 no 1543 0.460349534608299 513 3286988
SGTC_208 k072-0098 12.366 µM 0.0994462764860752 0.463966288116526 no 1544 0.460391970756777 505 5948901
SGTC_717 1532-0246 73.2 µM 0.0971489897662719 0.464877977643467 no 1545 0.461304038306655 484 9561992
SGTC_178 4092-0806 87.505 µM 0.0967683207189938 0.465029065964678 no 1546 0.461455191118751 501 2169044
SGTC_420 mitomycin C 81.9 mM 0.0965350334589395 0.465121660647055 no 1547 0.461547825583431 475 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1442 4112-3290 3 µM 0.0965169613324581 0.465128833782928 no 1548 0.461555001809377 508 704353
SGTC_2348 9022543 33.42 µM 0.096500019247409 0.465135558396333 no 1549 0.461561729320712 519 3162678 YDL140C RPO21
SGTC_1054 3429-0080 167 µM 0.0953165925977523 0.465605305907991 no 1550 0.462031681835372 504 1162877
SGTC_1000 4048-0884 8.67 µM 0.0932602083915153 0.466421677439311 no 1551 0.462848421683482 496 13040088
SGTC_889 0919-1524 82.7 µM 0.0929328246839841 0.466551659828731 no 1552 0.462978464126533 473 3905452
SGTC_3263 9137018 49.47 µM 0.0915480883506693 0.467101486216583 no 1553 0.46352854882529 514 43844957
SGTC_3100 9120536 49.47 µM 0.0900299145932049 0.467704367664061 no 1554 0.46413172147055 507 16421196
SGTC_2620 irigenin 100 µM 0.089409136935991 0.467950905880176 no 1555 0.464378381165182 521 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2924 9010168 62.78 µM 0.088966345151655 0.468126765564686 no 1556 0.464554328352664 498 2993929
SGTC_1965 Pectolinarigenin 58.4 µM 0.0875803541365874 0.468677267369467 no 1557 0.465105108648416 492 5320438 An anti-inflammatory.
SGTC_2625 euphol 100 µM 0.0865634169623656 0.469081222825235 no 1558 0.465509272870613 520 6708538 A triterpene alcohol.
SGTC_1249 0481-0015 10.2 µM 0.0864816499208417 0.469113704334375 no 1559 0.465541771328519 516 4227577
SGTC_2236 dapsone 200 µM 0.0859231712990555 0.469335562392081 no 1560 0.465763745796456 510 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2023 5144124 124 µM 0.0856832939661718 0.469430857631324 no 1561 0.465859091383255 521 2830192
SGTC_696 1560-0013 611 µM 0.0844656247412157 0.46991462376923 no 1562 0.466343116312815 498 1650269
SGTC_2582 agaric acid 100 µM 0.0833628956879345 0.470352763824282 no 1563 0.46678149536794 499 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_44 0929-0055 61.211 µM 0.0818771779015196 0.470943130926679 no 1564 0.467372191444647 514 1379590
SGTC_3131 9127911 49.47 µM 0.0817771164136873 0.470982893823114 no 1565 0.467411976784567 483 45595681
SGTC_2387 9077560 195.08 µM 0.081482599854457 0.471099931851772 no 1566 0.467529081082863 496 5303272
SGTC_2267 7931562 200 µM 0.0807137639703849 0.471405471524715 no 1567 0.467834795233394 502 934880
SGTC_603 3794-0023 45.9 µM 0.080692643576728 0.471413865125426 no 1568 0.467843193657325 502 3802260
SGTC_2370 9071495 200 µM 0.0801810987412167 0.471617165541474 no 1569 0.468046611387201 514 21791103
SGTC_345 1362-0200 395 µM 0.0795119896694306 0.471883096990505 no 1570 0.46831269771503 483 1419823
SGTC_1217 1183-1422 255 µM 0.0792632227751715 0.471981970382912 no 1571 0.468411629102952 504 2849664
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0786757455073072 0.472215472404364 no 1572 0.46864526897349 518 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2572 astragaloside iv 100 µM 0.0763097956441482 0.473155952009884 no 1573 0.469586316386396 512 45006101 An anti-inflammatory agent.
SGTC_1868 st057644 42.7 µM 0.0762283518864981 0.473188329098431 no 1574 0.469618713381428 495 688665
SGTC_1754 st042065 16.137 µM 0.0758683870717382 0.473331431351626 no 1575 0.469761903904701 506 1126236 YIL048W NEO1
SGTC_1779 st039427 55 µM 0.0749908182632113 0.473680318929732 no 1576 0.470111008643709 508 1124498
SGTC_1722 st034304 3.6505 µM 0.073489600535291 0.474277191974137 no 1577 0.470708259634677 506 4036148 YLR033W RSC58
SGTC_1401 3807-4679 7.6 µM 0.0734717352303713 0.474284295437322 no 1578 0.47071536764471 517 3291456
SGTC_2844 9010103 25.97 µM 0.0734478952595663 0.474293774513286 no 1579 0.470724852789915 515 2480525
SGTC_13 0199-0087 65 µM 0.0732004878248766 0.474392147717942 no 1580 0.470823289101536 518 4589825
SGTC_3134 9127454 49.47 µM 0.0726414256018709 0.47461444565721 no 1581 0.471045730457712 519 24262820
SGTC_216 k038-0035 28.382 µM 0.0722288996678441 0.47477848196045 no 1582 0.471209873311362 499 4444231 YPR107C YTH1
SGTC_1315 1237-0019 3.69 µM 0.0721991201254953 0.474790323626712 no 1583 0.471221722693128 517 825140
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0719039746219659 0.47490768776616 no 1584 0.471339163474414 488 6708561
SGTC_1432 4049-0298 68.4 µM 0.0699381948406642 0.475689432024212 no 1585 0.472121426228923 524 741646
SGTC_3320 9137005 35.139 µM 0.0693353305825993 0.475929195813105 no 1586 0.472361351828315 518 4908713
SGTC_2177 5811945 192 µM 0.0689589085035078 0.47607890621754 no 1587 0.472511163931496 522 5343475
SGTC_2725 haloperidol 53.21 µM 0.0687959070667035 0.476143736117922 no 1588 0.472576038029161 518 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2286 7945697 125 µM 0.0678103067566045 0.47653574832402 no 1589 0.472968319522255 500 1245733
SGTC_427 1354-0053 47.3 µM 0.0674912402631576 0.476662658565986 no 1590 0.473095317691818 498 6813657
SGTC_476 mead acid 10 µM 0.0669991677207959 0.476858387437074 no 1591 0.473291182887891 505 5312531 An omega 9 fatty acid.
SGTC_1042 0350-0096 82 µM 0.0661551127635811 0.477194135308803 no 1592 0.473627166635003 489 3122515
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0652307502048104 0.477561846472985 no 1593 0.473995139067999 478 4174840
SGTC_1505 k297-0037 20.6 µM 0.0650434190642574 0.477636369085875 no 1594 0.474069715005484 507 4089396
SGTC_349 k015-0014 24 µM 0.0649977098008842 0.477654552907219 no 1595 0.474087911857388 509 2196908
SGTC_145 3737-0113 38.366 µM 0.0648059433793376 0.477730840933894 no 1596 0.47416425463403 504 6849351
SGTC_1631 benzylvanillin 81.9 µM 0.0642872484437575 0.477937190905425 no 1597 0.474370753359793 493 75506
SGTC_289 k017-0060 526 µM 0.0642807893132349 0.477939760548404 no 1598 0.474373324861279 521 5512909
SGTC_2806 7952793 58.44 µM 0.0638666465594954 0.478104521324128 no 1599 0.474538205113977 513 2972490
SGTC_3142 9086498 49.47 µM 0.0634226981528383 0.478281144007998 no 1600 0.474714956560882 515 25236367
SGTC_804 1595-0054 20.9 µM 0.0614038641238562 0.479084380455915 no 1601 0.475518787521571 493 761523 Stimulates phospholipase C.
SGTC_1024 4507-0395 26 µM 0.0608890502635392 0.479289223922853 no 1602 0.475723784944961 495 4201836
SGTC_2003 4023581 200 µM 0.0582318974019423 0.480346585840168 no 1603 0.476781956684962 513 16641307
SGTC_1824 st053723 68.6 µM 0.0578695318769209 0.480490792982769 no 1604 0.476926276237903 508 675225
SGTC_2413 inermin 26.06 µM 0.0562858876769671 0.481121050433931 no 1605 0.477557030507176 517 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1025 k007-0731 70 µM 0.0560044644426807 0.481233056010966 no 1606 0.477669125317185 531 6256118
SGTC_675 1309-0189 238 µM 0.0559842241162904 0.481241111655495 no 1607 0.477677187390462 514 4246530
SGTC_1406 3909-7906 11.9 µM 0.0556649079865335 0.481368200401879 no 1608 0.477804377753519 521 X1406
SGTC_2233 sulbentine 40.3845 µM 0.0556330955484417 0.481380861948504 no 1609 0.477817049444 512 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_35 0133-0054 64.071 µM 0.0551568679274318 0.481570405717701 no 1610 0.478006745500892 514 99677
SGTC_573 3702-0553 84.7 µM 0.054552045935584 0.481811137444211 no 1611 0.478247671814064 511 1222756
SGTC_1812 st052057 4.327 µM 0.0540133581234155 0.482025551979188 no 1612 0.478462260767508 510 3645418
SGTC_1740 st038286 13.222 µM 0.0527973102953724 0.482509595928004 no 1613 0.478946702293432 517 716786
SGTC_888 0916-0002 6.97 µM 0.0513623341720563 0.483080816692764 no 1614 0.47951839905663 485 2802138 YIL048W NEO1
SGTC_2010 4012422 159 µM 0.051238398259393 0.483130153491999 no 1615 0.47956777731439 512 952393
SGTC_2545 solidagenone 89.61 µM 0.0507152922025267 0.483338396039133 no 1616 0.479776195457499 515 6708572 An anti ulcer agent
SGTC_1266 0828-0227 32.9 µM 0.049016591197989 0.484014660560676 no 1617 0.480453036984162 517 3913820
SGTC_1968 st069590 43.6 µM 0.0476542572754469 0.484557048361409 no 1618 0.480995895030205 531 6384066
SGTC_1713 st033146 12.748 µM 0.0473962557093033 0.484659770113839 no 1619 0.481098706589814 518 674619
SGTC_2460 5552655 174.22 µM 0.0472995648033278 0.484698267271868 no 1620 0.481137237466374 489 5401989
SGTC_579 4491-1009 110 µM 0.0466397889785613 0.484960958579252 no 1621 0.481400159750609 534 1271041
SGTC_594 1487-1584 10.8 µM 0.0446163712507524 0.485766627354088 no 1622 0.482206546641492 525 5013332
SGTC_193 1273-0060 1.558 µM 0.0442865163185709 0.485897972027167 no 1623 0.482338009774532 530 2847393 YHR072W ERG7
SGTC_1033 k072-0102 21.3 µM 0.0418401596631159 0.486872131634934 no 1624 0.483313060123557 532 5965931
SGTC_1559 coumarin 343 70.1 µM 0.0415517845836974 0.486986970269 no 1625 0.48342800517242 516 108770 A hepatotoxic, DNA x-linker.
SGTC_1897 st060201 15 µM 0.0410303281457137 0.487194630838655 no 1626 0.483635858924753 509 611878
SGTC_530 4358-1714 28 µM 0.0400776778262844 0.487574015477372 no 1627 0.484015599007412 528 1564641
SGTC_801 0866-0028 10.1 µM 0.039492492065338 0.487807066174097 no 1628 0.484248869656371 535 6849771
SGTC_3060 1327-0027 12.5 µM 0.0378249666277629 0.488471182079036 no 1629 0.484913619061352 533 16000455 YPR107C YTH1
SGTC_1247 0448-0043 5.84 µM 0.0377472427046332 0.488502137539394 no 1630 0.484944604292385 522 3089013 YGL099W LSG1
SGTC_2146 5545642 200 µM 0.0377254177577152 0.488510829872728 no 1631 0.484953304989243 533 825326
SGTC_743 1275-0778 158 µM 0.0377246088468292 0.488511152041912 no 1632 0.484953627468442 524 2849257 YMR203W TOM40
SGTC_46 0329-0187a 2.197 µM 0.0370594104576681 0.488776086614237 no 1633 0.485218817771478 525 46494817
SGTC_2949 9072542 2.23 µM 0.0362287431664797 0.489106930921396 no 1634 0.485549983647865 528 16457352
SGTC_2194 5927483 104.545 µM 0.0361454706308178 0.489140097739396 no 1635 0.485583182838728 515 760979
SGTC_217 ketoconazole 989 nM 0.0358860136504384 0.48924343796303 no 1636 0.485686624087532 531 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_113 0099-0221 2.5 µM 0.0349870413738455 0.489601498993908 no 1637 0.486045037016784 534 89219
SGTC_1659 st012954 42.1 µM 0.0342601416276624 0.48989102960584 no 1638 0.48633485428523 520 24207262
SGTC_3340 9146634 11.102 µM 0.0336078921230934 0.49015083090366 no 1639 0.486594914410361 536 4907387
SGTC_1735 st034310 56.75 µM 0.0324349178408761 0.490618055560348 no 1640 0.487062608359215 534 871153
SGTC_3070 9117005 49.47 µM 0.0315477873936919 0.490971430135048 no 1641 0.487416341131604 537 8779016
SGTC_2057 5236571 38.335 µM 0.0309236399790579 0.491220053784311 no 1642 0.48766521847979 529 54684039 YBR257W POP4
SGTC_2793 7325131 81.82 µM 0.0300490079222749 0.491568461511792 no 1643 0.488013984064111 528 4176441
SGTC_212 3807-4682 38.772 µM 0.029284903292871 0.491872846159243 no 1644 0.488318683583186 520 3125501 YBL034C STU1
SGTC_2539 epi(13)torulosol 80 µM 0.0290484695080073 0.491967031628575 no 1645 0.488412966904531 531 6708597
SGTC_2834 9001755 58.44 µM 0.0282632023492898 0.492279852864867 no 1646 0.488726114569425 530 2989575
SGTC_1297 1068-0111 14.1 µM 0.0276317997224325 0.49253138364583 no 1647 0.488977909416055 535 767057
SGTC_2399 5884133 200 µM 0.0275310167650318 0.492571532657054 no 1648 0.489018100708538 531 722445
SGTC_958 1222-0007 33 µM 0.0267606886590545 0.49287841151935 no 1649 0.489325303942726 533 7312461
SGTC_1269 0831-0796 3.05 µM 0.024967805037474 0.49359266615257 no 1650 0.490040321728593 536 927758
SGTC_3225 9130819 49.47 µM 0.0246240328021862 0.493729621637697 no 1651 0.490177424852846 538 4547121
SGTC_330 1488-0319 80.1 µM 0.0243040251654213 0.493857110204538 no 1652 0.49030505123147 543 6846614
SGTC_385 1494-0393 12.4 µM 0.0236905005277396 0.494101535417297 no 1653 0.490549741680752 531 3090647
SGTC_326 k292-0812 17.5 µM 0.0228086063773164 0.494452881586352 no 1654 0.49090147145764 536 3579357
SGTC_2459 5811157 9.22 µM 0.0219435771327521 0.494797512967834 no 1655 0.491246481803988 536 2870684 YBR192W RIM2
SGTC_2126 5251174 33.877 µM 0.0207026737584428 0.495291900938768 no 1656 0.491741418063614 534 790722
SGTC_928 2764-0428 58.7 µM 0.0199874939910739 0.495576838846007 no 1657 0.492026674461706 535 662578
SGTC_1712 st032288 53.4 µM 0.0195753773753788 0.495741033068181 no 1658 0.492191053038758 539 2883011
SGTC_1149 3909-7961 23.3 µM 0.0182317105089909 0.496276377513734 no 1659 0.492727002754468 546 735261
SGTC_1205 4161-2785 76 µM 0.0180331003557077 0.496355508465461 no 1660 0.492806223717431 527 3498106
SGTC_1328 1441-0025 69.2 µM 0.0179425262807978 0.496391595352882 no 1661 0.492842351700125 534 4562601
SGTC_2378 9074213 121.43 µM 0.0162626194751948 0.49706091562219 no 1662 0.4935124394664 538 657714
SGTC_653 0203-0016 55.2 µM 0.0159493337553772 0.497185738091065 no 1663 0.493637406175982 540 295302
SGTC_533 1222-0222 6.71 µM 0.0152075738547676 0.497481278658065 no 1664 0.493933289649564 532 3982874
SGTC_1377 2944-0135 198 µM 0.015202427522458 0.49748332912438 no 1665 0.493935342501795 537 1894137
SGTC_588 3970-1144 52.9 µM 0.0150376198516191 0.49754899390008 no 1666 0.494001083734604 544 1888707
SGTC_618 k072-0232 33.2 µM 0.0133657290438862 0.498215133421673 no 1667 0.494668004330172 544 5872756 YGL099W LSG1
SGTC_3030 9087619 49.47 µM 0.0130973137387382 0.498322079938869 no 1668 0.494775077170581 543 25236973
SGTC_1871 st057448 67.3 µM 0.0118087214305862 0.498835503991365 no 1669 0.4952891112298 541 691747
SGTC_658 3253-0951 102 µM 0.0115806617519312 0.498926371842938 no 1670 0.495380087656428 543 1184878
SGTC_87 0100-0052 35.5 µM 0.0109423747993003 0.499180690486707 no 1671 0.495634711158122 539 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2400 5203494 178.7 µM 0.0103037754168214 0.499435133948008 no 1672 0.495889461073069 541 6777674
SGTC_2097 5376186 200 µM 0.00973515784610881 0.499661694061198 no 1673 0.496116295274153 539 742755
SGTC_403 arphamenine a 50 µM 0.00970303942822689 0.499674491334808 no 1674 0.496129108063858 543 5487158 An arginine aminopeptidase inhibitor.
SGTC_2864 9034755 47.6 µM 0.00960366907713193 0.49971408449418 no 1675 0.496168749251242 539 4930451
SGTC_1901 st060216 58.6 µM 0.00936897857137899 0.499807594676401 no 1676 0.496262373003869 536 688792
SGTC_1550 gossypolone 36.6 µM 0.00912022351526176 0.499906708755317 no 1677 0.496361607672443 546 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_517 1365-0151 113 µM 0.00902472585872265 0.499944758887353 no 1678 0.496399704157412 536 768657
SGTC_1373 2887-0003 58.5 µM 0.00874743921379079 0.499944758887353 no 1679 0.49651032115613 545 776948
SGTC_1578 josamycin 24.2 µM 0.00870674313917467 0.499928543923799 no 1680 0.496526555922691 533 5282165 A P450 substrate.
SGTC_2416 tofa 880 nM 0.0083899644902321 0.499802326492577 no 1681 0.496652927701401 542 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1336 1486-0901 104 µM 0.00791983613090474 0.499615008372138 no 1682 0.496840475543131 543 5006114
SGTC_1702 st027038 51 µM 0.00788838496461901 0.499602476960176 no 1683 0.496853022351193 544 5521182
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.00720287184509331 0.499329341029585 no 1684 0.497126494727596 543 390807
SGTC_2178 5812956 200 µM 0.00508026913824809 0.498483613510404 no 1685 0.497973274562943 547 5403383
SGTC_157 1348-1695 65.819 µM 0.00446840098667366 0.498239822525993 no 1686 0.498217371852803 541 5380510
SGTC_348 k064-0012 10.7 µM 0.00446191513879302 0.498237238326799 no 1687 0.498219959305953 545 5066323
SGTC_1777 st045864 34.765 µM 0.00360485345486136 0.497895754273769 no 1688 0.498561874656938 547 4691462
SGTC_2049 5262831 67.185 µM 0.00317681796173934 0.49772521017361 no 1689 0.498732635129668 545 763417
SGTC_930 2810-3379 265 µM 0.00309271374551795 0.497691700201637 no 1690 0.498766187692612 541 1015764
SGTC_782 0083-0095 30.5 µM 0.00177776259555476 0.497167781337385 no 1691 0.499290775709694 540 3591729 An indicator and reagent.
SGTC_2888 9058547 12.99 µM 0.000799628427634502 0.49677806431854 no 1692 0.499680994445601 548 16476514
SGTC_2486 5283202 22.39 µM 0.000232103689184185 0.496551947389961 no 1693 0.499907404025779 548 1377751
SGTC_2781 5567276 71.43 µM 0.000137111840234872 0.496514100220724 no 1694 0.499945300289958 548 2853274
SGTC_1921 5740136 50 µM -0.000467865853516036 0.49627306246726 no 1695 0.499813348536286 550 1774243
SGTC_1100 amiodarone 5.07 µM -0.000576212577620126 0.496229894651532 no 1696 0.499770124453009 548 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_465 cgp-37157 41 µM -0.000923096434658424 0.496091688479603 no 1697 0.499631737855627 550 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1283 0922-0125 16.4 µM -0.00100519321027465 0.496058979383295 no 1698 0.499598985995981 548 3360884
SGTC_406 estrone 100 µM -0.00151776486510656 0.495854760574466 no 1699 0.499394499656074 551 5870 A steroid.
SGTC_2344 7990960 76.95 µM -0.00280206851204591 0.495343073178927 no 1700 0.498882137860796 554 140813
SGTC_806 3966-4455 5.86 µM -0.00289306231615506 0.49530682005283 no 1701 0.498845836732271 554 714982
SGTC_991 3996-0057 64.7 µM -0.00349413209256858 0.495067346950928 no 1702 0.498606045811422 553 715343
SGTC_1310 1188-0297 994 nM -0.00424332407885012 0.49476886275798 no 1703 0.498307163695648 550 1588352
SGTC_1390 3413-2614 145 µM -0.00428329985438172 0.494752936164043 no 1704 0.498291215813531 552 3421432
SGTC_655 k060-0012 42 µM -0.00432809648143634 0.494735088923256 no 1705 0.498273344710638 549 5994525
SGTC_402 epigallocatechin gallate 10 µM -0.00500418182678518 0.494465733828791 no 1706 0.498003628622616 550 65064 An antioxidant.
SGTC_794 k038-0031 316 µM -0.00538991934312996 0.494312055588448 no 1707 0.497849743697342 551 6624242
SGTC_1420 4'-methoxyflavone 42 µM -0.00663717862760477 0.493815152045176 no 1708 0.497352168263328 551 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1058 3448-5425 97.3 µM -0.00693039073492506 0.493698338777232 no 1709 0.497235196248553 553 7279705
SGTC_453 enantio-paf c16 10 µM -0.00717955854183345 0.493599072817025 no 1710 0.497135795149479 556 13871343 A lipid and platelet activating factor
SGTC_228 caffeine 993.056 µM -0.00734650419142206 0.49353256356266 no 1711 0.497069195228057 553 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2143 5623677 140.463 µM -0.00752742951272947 0.493460485168604 no 1712 0.496997018463912 554 5375313
SGTC_2329 6138490 200 µM -0.00759777175571858 0.493432461752828 no 1713 0.496968956771567 556 720019
SGTC_2406 ethylparaben 405.7 µM -0.0077027463471712 0.493390641329505 no 1714 0.49692707919418 569 8434 A possible steroid mimic.
SGTC_2284 7945075 39.21 µM -0.00845824277472136 0.493089664187212 no 1715 0.496625689573392 553 1245402
SGTC_2445 5742597 35.57 µM -0.00856164626513153 0.493048470268115 no 1716 0.496584439042836 552 1774255
SGTC_2367 9070478 135.38 µM -0.00903912939630942 0.492858251337766 no 1717 0.496393958211651 553 572802
SGTC_1748 st037455 53.6035 µM -0.00910632795945585 0.492831481016055 no 1718 0.496367150966968 551 580690
SGTC_925 2064-1272 59.6 µM -0.00913663337977243 0.492819408062346 no 1719 0.496355061356426 565 6815817
SGTC_2687 chenodiol 100 µM -0.0113462645500491 0.491939162357209 no 1720 0.495473592466471 554 5702181 A cholesterol synthesis inhibitor.
SGTC_1731 st035964 63 µM -0.0118303741132217 0.491746313833077 no 1721 0.495280473662575 576 6739575
SGTC_661 1304-0007 33.6 µM -0.0121165674937871 0.491632307547332 no 1722 0.49516630720706 557 3117130
SGTC_2401 5128683 200 µM -0.013802774312685 0.490960614456254 no 1723 0.49449366458175 561 708373
SGTC_271 rotenone 740 µM -0.0139694558944233 0.49089421894025 no 1724 0.494427174662249 554 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_532 1548-0774 215 µM -0.0141288864492571 0.490830712015856 no 1725 0.494363577349909 576 5932993
SGTC_1830 st055982 50.3 µM -0.0160942924259351 0.49004783971747 no 1726 0.493579583455415 554 455313 An antimicrobial agent.
SGTC_2441 5730946 39.09 µM -0.0162880117411839 0.48997067830438 no 1727 0.493502310759467 555 1774275
SGTC_3154 9100113 49.47 µM -0.0165253863798349 0.489876128809755 no 1728 0.493407624724677 561 25237525
SGTC_2188 6126565 140.678 µM -0.0167523684608389 0.489785719341896 no 1729 0.493317084509863 551 874518
SGTC_310 1273-0058 1.06 µM -0.0173248795397964 0.489557684202575 no 1730 0.493088718788957 559 2734232
SGTC_1973 st070275 50.2 µM -0.0175455296472482 0.489469798639357 no 1731 0.493000705510533 553 17118334
SGTC_552 k242-0005 476 µM -0.017614469812682 0.489442339680683 no 1732 0.492973206613412 556 4088318
SGTC_3215 9129942 49.47 µM -0.0179312472591346 0.489316167451857 no 1733 0.492846850654961 554 17682944
SGTC_419 nsc-638432 893 µM -0.0188705385867478 0.488942054726128 no 1734 0.492472191078431 561 368090
SGTC_262 fenpropimorph 62.5 µM -0.0191722571634986 0.48882188451749 no 1735 0.492351844555311 559 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.019563054931143 0.488666236846777 no 1736 0.49219596804156 565 616764
SGTC_2239 6685329 187.64 µM -0.0196498489943938 0.488631668577262 no 1737 0.49216134887472 570 805680
SGTC_1170 0310-0127 64.8 µM -0.0209843010801406 0.488100194983775 no 1738 0.491629089421338 566 774975
SGTC_100 0086-0128 49.5915 µM -0.0218064070226286 0.487772784470379 no 1739 0.491301191669162 560 93297
SGTC_409 arachidonic acid 100 µM -0.0234331936863985 0.487124927681271 no 1740 0.490652363768691 560 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2456 5770359 74.46 µM -0.0239548846699742 0.486917174887441 no 1741 0.49044429759355 554 3118787
SGTC_2325 6158266 200 µM -0.0247705849655455 0.48659234601852 no 1742 0.490118976826761 555 3623240
SGTC_1724 st037281 8.293 µM -0.0264004918894083 0.48594330994973 no 1743 0.489468950908376 561 574124 YDL195W SEC31
SGTC_77 0828-0286 12.516 µM -0.0270796389855332 0.485672881495342 no 1744 0.489198107270447 572 745345
SGTC_1663 st014140 55.4 µM -0.0276417383490493 0.485449065061163 no 1745 0.488973945991591 573 4207120
SGTC_255 tunicamycin 200.472 nM -0.0282440408675173 0.485209245644738 no 1746 0.488733755844161 562 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2451 5856223 45.7 µM -0.0289297087130893 0.484936239086306 no 1747 0.488460325703276 556 2179896
SGTC_1236 0330-0013 258 µM -0.0290160702741465 0.484901853733062 no 1748 0.488425886882674 572 4617066
SGTC_1276 0871-0068 94.2 µM -0.0293044116215393 0.484787049778487 no 1749 0.48831090422481 562 3414906
SGTC_3284 9108171 64.8615 µM -0.0302139054445367 0.484424940447439 no 1750 0.487948229326915 557 8687505
SGTC_69 0096-0274 206.684 µM -0.0305135534159312 0.484305640262461 no 1751 0.487828742175985 565 6741392
SGTC_2753 fluvastatin 17.09 µM -0.0308520814697179 0.484170862267384 no 1752 0.487693752579814 567 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1523 st012844 44.7 µM -0.031047022689976 0.484093251242016 no 1753 0.487616019523167 573 4274103
SGTC_1513 0337-0559 19 µM -0.0311026188532978 0.484071117114965 no 1754 0.487593850569241 560 775073
SGTC_117 lucigenin 22.078 µM -0.0318761081934437 0.483763178122059 no 1755 0.48728542592747 576 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2452 5863136 48.41 µM -0.0321919729296208 0.483637429882659 no 1756 0.487159478768638 562 2184096
SGTC_1791 st048313 56.1 µM -0.0343996405263131 0.482758586158745 no 1757 0.486279235060973 558 1204976
SGTC_2512 diallyl trisulfide 49.23 µM -0.0344307245099797 0.482746212617619 no 1758 0.486266841687205 563 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1416 3966-0321 25.3 µM -0.0345997346875489 0.482678935354971 no 1759 0.486199456531595 563 582530 YLR208W SEC13
SGTC_2602 kawain 100 µM -0.0350727634053593 0.482490641173072 no 1760 0.486010859849795 560 5369129
SGTC_929 2805-0021 398 µM -0.0356816908464391 0.482248256794535 no 1761 0.485768084921406 607 3098024
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0357272183802594 0.482230134761606 no 1762 0.485749933636635 572 5379071
SGTC_2112 5488546 200 µM -0.0379405975527396 0.481349153995839 no 1763 0.484867522085358 570 600757
SGTC_620 0109-0052 432 µM -0.0386253886680811 0.4810766080984 no 1764 0.484594530081692 557 493037
SGTC_1851 st056236 18.9 µM -0.0386524128995685 0.481065852672987 no 1765 0.48458375701806 565 5393171
SGTC_1568 digitonin 820 nM -0.0392760410942386 0.480817657543652 no 1766 0.484335154155426 567 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1122 capsaicin 818.572 nM -0.0407258382760851 0.480240687838312 no 1767 0.483757231357118 559 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2780 5215298 71.43 µM -0.0413321444175317 0.479999410931333 no 1768 0.483515553709191 581 2834131
SGTC_706 4262-0057 46.9 µM -0.0416279618037282 0.479881694336086 no 1769 0.483397641130521 576 883298
SGTC_3219 9131112 49.47 µM -0.0422196707046981 0.47964623692225 no 1770 0.483161790792799 567 17612988 YMR079W SEC14
SGTC_679 0422-0091 41.4 µM -0.0436734837863102 0.479067754630107 no 1771 0.482582337958069 565 627384 YHR062C RPP1
SGTC_182 3448-4371 550.524 µM -0.0440761516580642 0.478907538040877 no 1772 0.482421851262926 563 3491403
SGTC_2906 7926292 26.41 µM -0.0447303595725292 0.47864724404337 no 1773 0.482161117235064 573 2966319
SGTC_1353 1498-1206 8.11 µM -0.0464334355411864 0.477969673018638 no 1774 0.481482393767802 565 6756808
SGTC_1792 st045773 43.6 µM -0.0466563069310183 0.477881008011223 no 1775 0.481393577206826 579 2919270
SGTC_1964 st076914 61 µM -0.0469569329679541 0.477761411578965 no 1776 0.481273776076191 572 24208661
SGTC_112 phenothiazine 287.218 µM -0.0473782292536679 0.477593812925789 no 1777 0.481105890035207 570 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1448 4255-0083 152 µM -0.0480299055708672 0.477334573089562 no 1778 0.480846204452289 592 5399660
SGTC_2696 st077691 74.316 µM -0.0485281354852973 0.477136381401722 no 1779 0.480647670988227 572 757133
SGTC_1909 st060837 51.5 µM -0.0492781299776189 0.476838050551996 no 1780 0.480348824044586 579 678937
SGTC_2007 4011539 71.82 µM -0.0502377281170532 0.476456363063561 no 1781 0.479966473404016 566 45595301
SGTC_2908 7930301 100 µM -0.0506806590949071 0.476280191149366 no 1782 0.479789994323522 569 2223178
SGTC_892 0929-0076 29 µM -0.0518861933266337 0.475800724056922 no 1783 0.479309687793158 562 5751038
SGTC_2693 st077581 40.7 µM -0.0524504405251314 0.47557632271198 no 1784 0.479084891835119 583 25238761
SGTC_3350 9150499 3.57 µM -0.0524992009120676 0.475556931048495 no 1785 0.479065466019113 572 4910996 YPR165W RHO1
SGTC_2155 5570423 76 µM -0.0528202087924007 0.47542926991598 no 1786 0.478937579843867 580 797402
SGTC_1224 0823-0416 294 µM -0.0531515674614764 0.475297495039949 no 1787 0.478805572297401 576 3598164
SGTC_1908 st060353 56.5 µM -0.0546571627908128 0.474698783404437 no 1788 0.478205798728417 590 4227716
SGTC_659 k018-0002 107 µM -0.0550743685819338 0.474532888344344 no 1789 0.47803960802622 573 6797879 YHR007C ERG11
SGTC_2157 5649910 96.377 µM -0.055343359845254 0.47442593070689 no 1790 0.477932459458459 584 2858091
SGTC_1179 1021-1431 9.29 µM -0.0554557002012519 0.474381261923741 no 1791 0.47788771086253 578 2840958
SGTC_2565 isoliquiritigenin 100 µM -0.0558072342436091 0.474241487007277 no 1792 0.477747685917299 575 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3332 9141069 11.198 µM -0.0559692599160943 0.474177064370461 no 1793 0.477683147896981 584 17332883
SGTC_1044 1222-0021 1.78 µM -0.0582289256515296 0.473278675261579 no 1794 0.476783140233569 580 4306703
SGTC_835 0312-0010 67.2 µM -0.0587053475714266 0.473089278482122 no 1795 0.476593399970146 579 1626196
SGTC_1318 1280-3875 124 µM -0.058710940979778 0.473087054914503 no 1796 0.476591172365256 579 373245
SGTC_744 1594-0068 283 µM -0.0600413295258307 0.472558204775206 no 1797 0.476061358922898 576 668392
SGTC_1212 0520-0165 585 µM -0.0629526277049767 0.471401088495779 no 1798 0.474902113533368 600 5403258
SGTC_372 0155-0182 15.9 µM -0.0639998884167099 0.470984905759127 no 1799 0.474485157828913 567 771486
SGTC_1070 indatraline 8.81 µM -0.0644461110697498 0.470807585910752 no 1800 0.47430750749338 574 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_74 000s-0487 160.283 µM -0.0661894204632687 0.470114885851822 no 1801 0.473613509775925 575 677548
SGTC_140 0062-0056 502.533 µM -0.0662448027759414 0.470092881285633 no 1802 0.473591463815362 587 3758964
SGTC_2335 9018011 154.17 µM -0.0667035189943057 0.469910627130636 no 1803 0.473408866400761 585 6458208
SGTC_1801 st050089 28.441 µM -0.067399383629314 0.469634162750287 no 1804 0.473131879933695 587 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1052 3253-3998 198 µM -0.0676333643233599 0.469541206389949 no 1805 0.473038747654265 597 5450317
SGTC_253 dyclonine 31.25 µM -0.0678639082270147 0.469449617028869 no 1806 0.472946984775837 570 3180 An oral anasthetic.
SGTC_3047 9092122 49.47 µM -0.0703818653675647 0.468449401539728 no 1807 0.471944862395372 589 17173831
SGTC_137 0438-0332 85.389 µM -0.071655774092884 0.467943438503724 no 1808 0.47143792640062 596 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_138 0850-0259 40.9225 µM -0.072038900398523 0.467791280904176 no 1809 0.47128547510755 588 6813004
SGTC_2316 5844804 197.44 µM -0.0730334608502124 0.467396315867422 no 1810 0.470889745345393 605 776813
SGTC_2160 5660466 132.927 µM -0.0732721822108499 0.467301518357008 no 1811 0.470794763781023 604 2859134
SGTC_2800 7887935 81.82 µM -0.0733615979190079 0.467266011385192 no 1812 0.47075918782004 591 2961002
SGTC_941 3237-0776 460 µM -0.0744506352755515 0.466833575711973 no 1813 0.470325909719447 583 760008
SGTC_2005 4024620 188 µM -0.0754782054184594 0.466425583365981 no 1814 0.469917118810386 579 236743
SGTC_1603 st002045 67.8 µM -0.0758599565402145 0.466274019674924 no 1815 0.469765257535575 607 5887985
SGTC_2715 st079500 56.4 µM -0.0765973648805098 0.465981266020872 no 1816 0.469471927658493 583 28246688
SGTC_1237 0330-0133 46.1 µM -0.0778445244964262 0.465486181326822 no 1817 0.468975864227981 600 X1237 YHR072W ERG7
SGTC_1783 st039459 87.517 µM -0.0787138057826715 0.465141134459393 no 1818 0.468630132063526 574 729761
SGTC_1003 4049-0218 100 µM -0.0788665519156847 0.46508050710134 no 1819 0.46856938402454 575 295161
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0790489391812854 0.46500811577049 no 1820 0.468496848490822 598 16486 A toxic proline analog.
SGTC_221 trifluoperazine 10.304 µM -0.079320215645034 0.464900445570371 no 1821 0.468388963600605 577 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1255 0566-0045 221 µM -0.079728537443084 0.464738386635938 no 1822 0.468226581049032 599 2788469
SGTC_2472 5377652 49.4 µM -0.0807014938278555 0.464352253370536 no 1823 0.46783967439538 623 1610903
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0808861340539783 0.464278979729672 no 1824 0.467766253626293 570 66535 A nucleotide analog.
SGTC_839 0122-0028 230 µM -0.0809703429142896 0.464245562225414 no 1825 0.467732768983096 589 759448
SGTC_817 1391-0715 46 µM -0.0819896058419677 0.46384109726884 no 1826 0.467327489481765 580 1353946
SGTC_724 3910-0327 137 µM -0.0821578697655678 0.46377433018923 no 1827 0.467260587597179 587 2885483
SGTC_583 1488-1091 88.9 µM -0.0831931469537898 0.463363555000028 no 1828 0.466848980894963 601 4303273
SGTC_3299 9121982 43.1275 µM -0.0835334543503836 0.46322853702761 no 1829 0.466713688806581 605 17594604 YPL160W CDC60
SGTC_1525 8-methoxypsoralen 92.5 µM -0.0859099368992619 0.462285779434445 no 1830 0.465769006107319 593 4114 Related to psoralen; DNA damaging agent.
SGTC_1932 st074806 40.9 µM -0.0859594559657596 0.46226613731027 no 1831 0.465749323667512 584 17251235
SGTC_2997 9067075 71.4286 µM -0.0863775320434888 0.462100307844105 no 1832 0.46558315349897 588 27209819
SGTC_1979 st071809 45.3 µM -0.0868091592021651 0.461929110266883 no 1833 0.465411603560212 627 4976333
SGTC_858 0438-0351 2.77 µM -0.0869878800955628 0.461858225724883 no 1834 0.465340572935125 590 2799119
SGTC_2293 7624732 200 µM -0.0880774988977935 0.461426085814519 no 1835 0.46490754007127 578 894453
SGTC_2327 6189656 200 µM -0.0892032113517739 0.460979679091615 no 1836 0.464460206632416 601 5349088
SGTC_1062 mesoridazine 14.2 µM -0.0900264566353398 0.46065324828262 no 1837 0.46413309541688 575 4078 A neuroleptic.
SGTC_3105 9121040 49.47 µM -0.0917437328887091 0.4599724045228 no 1838 0.463450825033588 590 41448907
SGTC_1204 4049-0315 18.3 µM -0.0918080795861925 0.459946895434455 no 1839 0.463425262297494 588 588402
SGTC_236 1509-0011 5.31 µM -0.0918772550663133 0.459919472246165 no 1840 0.463397781420105 605 3107280
SGTC_2927 9011802 47.9 µM -0.0919581525956129 0.459887402335813 no 1841 0.463365644024705 600 43912568
SGTC_179 1273-0063 6.77 µM -0.092097925479959 0.459831993299837 no 1842 0.46331011833803 612 3108139
SGTC_843 0310-0051 143 µM -0.0926186606630742 0.459625569331492 no 1843 0.463103259202856 583 2065037
SGTC_2551 apiole 73.87 µM -0.0929818640921735 0.459481598763789 no 1844 0.46295898457733 585 10659 A possible DNA adduct former.
SGTC_1809 st050081 57.6 µM -0.0930921686043173 0.459437876099736 no 1845 0.46291516948392 586 5036894
SGTC_2308 7584454 197.62 µM -0.0932607047578386 0.459371072440001 no 1846 0.462848224521247 612 893577
SGTC_2053 5265679 138 µM -0.0933212062525368 0.459347091388829 no 1847 0.462824192721664 579 764595
SGTC_2688 kanamycin b 96.69 µM -0.0935731535997514 0.45924722830336 no 1848 0.462724118172237 598 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2066 5222451 176 µM -0.0942157665159507 0.458992530756065 no 1849 0.462468880307997 593 2281147
SGTC_54 0159-0055 9 µM -0.0958041505505992 0.458363052328895 no 1850 0.461838060431547 608 3319099
SGTC_2520 obtusaquinone 4.71 µM -0.0964147848364317 0.458121084953924 no 1851 0.461595575113044 584 5967872
SGTC_1620 st003704 16.5 µM -0.0967007051973584 0.458007792682784 no 1852 0.461482039895207 581 2834414
SGTC_3041 9091929 49.47 µM -0.0970162686675807 0.457882758671099 no 1853 0.461356737432695 587 25236887
SGTC_1239 0337-0584 35.4 µM -0.0974917524802398 0.457694368160095 no 1854 0.461167941799382 606 914301 YML130C ERO1
SGTC_964 1287-0107 19.4 µM -0.0975969420640468 0.457652692483394 no 1855 0.461126176397165 610 51516812 YPR165W RHO1
SGTC_2491 paeonol 100 µM -0.0983711765411981 0.457345958351647 no 1856 0.460818780718323 600 11092 Increases levels of cortical cytochrome oxidase.
SGTC_65 0798-0905 34.986 µM -0.0989828406124402 0.457103648881556 no 1857 0.460575947198738 658 3602145
SGTC_130 0136-0219 337.655 µM -0.099687389844972 0.456824562913556 no 1858 0.460296256057987 595 234244
SGTC_1494 4358-1428 177 µM -0.100129442583889 0.456649467892079 no 1859 0.460120780492241 619 1564571
SGTC_2981 9013952 38.96 µM -0.100353899531648 0.456560564764975 no 1860 0.460031683891049 593 2996344
SGTC_3138 9097216 49.47 µM -0.101397349576529 0.456147302671859 no 1861 0.459617520181735 589 25237486
SGTC_103 0844-0104 51.839 µM -0.102214148434413 0.455823839661295 no 1862 0.459293348874341 591 5375804
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.10233729377321 0.455775075034131 no 1863 0.459244477268086 608 7104
SGTC_47 0149-0135 24.25 µM -0.103038103533236 0.455497572350451 no 1864 0.458966364817248 589 5239155
SGTC_2205 7238770 200 µM -0.103065838466546 0.455486590474211 no 1865 0.458955358775615 616 279867
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.103445023779683 0.455336452328044 no 1866 0.458804889990125 588 115019
SGTC_20 0481-0013 4.944 µM -0.10367446509351 0.455245608304666 no 1867 0.458713845668578 591 182045
SGTC_2074 5212007 75.395 µM -0.106616299956597 0.454081039660137 no 1868 0.457546693399087 588 758611
SGTC_1152 3909-8331 15.9 µM -0.108061787331697 0.453508966179501 no 1869 0.456973339946022 602 16001939
SGTC_1970 st070122 35.8 µM -0.108082537510794 0.45350075468188 no 1870 0.456965110023929 622 102928
SGTC_885 0865-0106 16.8 µM -0.111294503567551 0.452229920685808 no 1871 0.455691406923593 593 2793380
SGTC_2088 5278280 127.392 µM -0.113101638583863 0.45151513090985 no 1872 0.454974987963842 603 791502
SGTC_315 k915-0449 187 µM -0.113141121319196 0.451499515751038 no 1873 0.454959337090193 608 20970215 YNL149C PGA2
SGTC_2092 5303694 80.6725 µM -0.114226965855639 0.451070100964522 no 1874 0.454528938073066 619 1963699
SGTC_1597 7-benzyloxygramine 47.5 µM -0.114810541706495 0.450839340077791 no 1875 0.45429764662008 602 260807
SGTC_1080 nisoldipine 24.4 µM -0.117051844668054 0.449953226423258 no 1876 0.453409484854783 610 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_364 0083-0097 67.7 µM -0.117105172815989 0.449932145815266 no 1877 0.453388355314523 615 5207356
SGTC_272 doxorubicin 8.13 µM -0.117117768745444 0.449927166667075 no 1878 0.453383364607333 599 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_464 bw-b 70c 158 µM -0.117265145903263 0.449868909328345 no 1879 0.453324971985259 631 5353454
SGTC_1667 st014849 34.6 µM -0.117670172464532 0.449708810237706 no 1880 0.453164500737808 588 5348460
SGTC_1863 st057641 20.1 µM -0.118035631189615 0.44956435856452 no 1881 0.453019712802959 593 3921635
SGTC_2219 9098279 200 µM -0.118351182002089 0.449439638931278 no 1882 0.452894702476591 592 902349
SGTC_2338 7999974 200 µM -0.119923894992483 0.44881810794442 no 1883 0.452271717804529 622 315925
SGTC_2444 5485484 36.41 µM -0.120057669059955 0.44876524664816 no 1884 0.452218732484983 627 6790631
SGTC_1132 3456-3614 2.5 µM -0.120547649599316 0.448571636877376 no 1885 0.452024667948361 639 3125502
SGTC_2488 5268135 45.7 µM -0.12102666953657 0.448382369892676 no 1886 0.45183495561164 616 1270356 YLR208W SEC13
SGTC_3043 9092303 49.47 µM -0.121363993469176 0.448249095882566 no 1887 0.451701367536263 602 25236084
SGTC_505 gw-5074 63.9 µM -0.122245916265712 0.447900682816146 no 1888 0.451352131599188 595 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1729 st035615 45.989 µM -0.123407667881019 0.44744178175513 no 1889 0.450892142698913 596 17385451
SGTC_1771 st048882 4.1505 µM -0.126638521436774 0.446165940836341 no 1890 0.449613253340371 607 4580403
SGTC_2431 5490079 200 µM -0.126731966761871 0.446129048173896 no 1891 0.449576272002711 630 5722345
SGTC_1552 6-methylflavone 10.6 µM -0.127407588649209 0.445862323307752 no 1892 0.449308905158119 608 689013
SGTC_1861 st057647 17.4 µM -0.127988407017445 0.44563304495417 no 1893 0.449079073722319 594 688668
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.128900335319392 0.445273097492585 no 1894 0.448718255668524 629 5282309
SGTC_1073 triclabendazole 3.09 µM -0.13000091764044 0.444838746455235 no 1895 0.448282850340281 614 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1488 4013-0813 75.9 µM -0.131650682777552 0.444187781505785 no 1896 0.447630297657423 607 2910057
SGTC_311 1315-0136 58 µM -0.131735170807442 0.444154448224277 no 1897 0.447596882827228 610 6759207
SGTC_3163 9099914 49.47 µM -0.133277709541666 0.44354593609759 no 1898 0.446986877763795 599 16268368
SGTC_279 1273-0055 2.93 µM -0.133310580540894 0.443532970345161 no 1899 0.446973880113576 611 2847562
SGTC_2377 9073351 62.6 µM -0.133505161382815 0.443456220432721 no 1900 0.446896941309652 650 7337946 YHR072W ERG7
SGTC_2022 5136654 200 µM -0.134982812504629 0.442873449356426 no 1901 0.446312731793163 620 1713771
SGTC_556 4058-0063 51.5 µM -0.13567512018045 0.442600452447469 no 1902 0.446039058520957 623 6615692
SGTC_2226 7298446 200 µM -0.138024310226628 0.441674302860904 no 1903 0.445110602322268 612 3283010
SGTC_2433 5607874 27.82 µM -0.138346802047095 0.441547187784635 no 1904 0.444983169210723 595 2252428
SGTC_3151 9099821 49.47 µM -0.13912308808639 0.441241227499034 no 1905 0.444676441993521 645 17174189
SGTC_1859 st055998 20 µM -0.139681704896105 0.44102107961924 no 1906 0.444455741028542 643 676301
SGTC_1388 3346-4487 254 µM -0.139774139311935 0.440984653468634 no 1907 0.444419223262051 631 3345614
SGTC_1687 st020778 55.3625 µM -0.140110015850263 0.440852296915871 no 1908 0.444286533575719 593 4259299
SGTC_1005 4092-0690 4.4 µM -0.140585124060468 0.440665085583793 no 1909 0.444098850396107 632 1529343
SGTC_657 3534-0529 86.7 µM -0.14194265368835 0.440130238704838 no 1910 0.443562651307922 631 1049549
SGTC_1145 3546-0597 10.2 µM -0.142110895433446 0.440063961498011 no 1911 0.443496206106626 607 875334
SGTC_268 camptothecin 39.6153 µM -0.142636903744264 0.439856756458061 no 1912 0.443288475245592 622 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1157 4092-0394 27.6 µM -0.142750178988222 0.43981213726081 no 1913 0.443243742697265 612 3659885
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.143958179351257 0.439336352737807 no 1914 0.442766746806588 603 2333 A French combination drug.
SGTC_625 k213-0058 121 µM -0.1441213081949 0.439272109308822 no 1915 0.442702339435646 604 3655420
SGTC_1021 4476-0760 85.3 µM -0.144154746099819 0.439258940984887 no 1916 0.442689137496608 611 746768
SGTC_2083 5306046 65.942 µM -0.144340881034034 0.439185639621569 no 1917 0.442615648946518 615 539837
SGTC_2626 ethyl orsellinate 100 µM -0.144633468396262 0.439070420692688 no 1918 0.442500135552607 610 75653 A natural product.
SGTC_161 4065-0411 162.148 µM -0.144673415568814 0.439054690166002 no 1919 0.442484364801123 645 1906281 YLR208W SEC13
SGTC_1351 1496-0003 46.5 µM -0.145192125320631 0.438850439712074 no 1920 0.442279591568708 609 3891978
SGTC_2846 9008642 19.48 µM -0.147500485519706 0.43794168331165 no 1921 0.441368498266033 667 2992898
SGTC_1480 1070-0044 41.2 µM -0.147912872917319 0.437779368744146 no 1922 0.441205764419754 601 3124987
SGTC_3300 9124615 50.48 µM -0.149065800496486 0.437325635190845 no 1923 0.440750855792943 628 24824903
SGTC_1185 1319-0113 81.3 µM -0.14917687562454 0.437281926022779 no 1924 0.440707033192277 630 4672763
SGTC_947 3447-0010 211 µM -0.149798468854737 0.437037337044524 no 1925 0.4404618087022 630 748350
SGTC_1008 4106-0037 6 µM -0.150378332552428 0.436809189795978 no 1926 0.440233067495895 618 2905394
SGTC_1510 1123-0200 71.5 µM -0.150550443176636 0.436741476948719 no 1927 0.440165178148632 656 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1484 3473-2379 286 µM -0.152021606499884 0.436162758425576 no 1928 0.43958494709579 606 671917
SGTC_119 0121-0043 24.815 µM -0.152884639349764 0.435823326592784 no 1929 0.439244624760235 630 1092378
SGTC_1942 st076330 65.2 µM -0.154328309555833 0.435255635194466 no 1930 0.438675438451886 663 24208414
SGTC_3249 9135183 49.47 µM -0.155306127110422 0.434871205766612 no 1931 0.438289992744776 636 4902779
SGTC_3173 9105693 49.47 µM -0.156977037813505 0.434214429115802 no 1932 0.437631472447393 645 17096658
SGTC_1677 st019204 53.9 µM -0.157195438356614 0.43412859686548 no 1933 0.437545411636276 625 3945625
SGTC_718 1130-0073 349 µM -0.157945223067314 0.433833952256608 no 1934 0.437249981213762 641 6740020
SGTC_726 3448-4391 34.2 µM -0.158485687254339 0.433621587602074 no 1935 0.437037049022165 644 1356692
SGTC_1764 st044502 93.5 µM -0.161828319842391 0.432308594624735 no 1936 0.435720525487045 619 8407
SGTC_2900 5328528 85.29 µM -0.16200525875123 0.432239113352709 no 1937 0.435650856346882 608 795359
SGTC_2873 9040596 71.43 µM -0.162619681371133 0.431997855035364 no 1938 0.435408944889671 639 6463863
SGTC_1711 st032263 62.8 µM -0.16266661993997 0.43197942524476 no 1939 0.435390465153859 623 3958979
SGTC_1570 verbenone 133 µM -0.163255391918928 0.431748264522334 no 1940 0.435158677357043 633 29025 A natural terpanoid with antifungal properties.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.163661502071889 0.431588833190037 no 1941 0.434998812859881 635 6708760
SGTC_2084 5306078 60.6385 µM -0.163746729534236 0.431555375879013 no 1942 0.434965264577791 645 679340
SGTC_2920 7982904 15.77 µM -0.16540672986326 0.430903816208673 no 1943 0.43431192848666 644 6456808
SGTC_2322 7413319 38.22 µM -0.166767244741972 0.430369946413285 no 1944 0.433776596311435 615 1840400
SGTC_557 1315-0110 16.2 µM -0.167566356102474 0.430056432167229 no 1945 0.43346222041817 613 6833801
SGTC_375 3970-0961 9.27 µM -0.168678446995081 0.429620200518519 no 1946 0.433024786322844 614 2898222
SGTC_1293 1000-1278 195 µM -0.169169502887265 0.429427604978394 no 1947 0.432831658597944 646 678847
SGTC_1233 0325-0408 14.2 µM -0.169508162276069 0.429294790191678 no 1948 0.432698476347869 641 12874
SGTC_2277 7947813 106.88 µM -0.169884013669625 0.4291473988871 no 1949 0.432550676805045 656 1246798
SGTC_1865 st057639 52.2 µM -0.171495956024197 0.428515382909189 no 1950 0.431916904982406 618 688818
SGTC_58 0957-0393 9 µM -0.172255945307208 0.428217467141102 no 1951 0.431618158567126 628 6997992
SGTC_2361 9034121 116 µM -0.173112411655328 0.427881781401809 no 1952 0.431281534576912 636 6496917
SGTC_545 4218-0007 221 µM -0.17316474589439 0.427861271068003 no 1953 0.431260966837374 641 2840508
SGTC_2055 5235184 200 µM -0.173399013728963 0.427769461451623 no 1954 0.431168900146739 642 2836034
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.173771596896269 0.427623454083237 no 1955 0.431022483571654 643 5282362
SGTC_2742 clothiapine 36.27 µM -0.174739881028857 0.427244050654796 no 1956 0.430642014661062 622 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3316 9136639 10.545 µM -0.175446140361422 0.426967358997674 no 1957 0.430364544010992 656 4903665
SGTC_2729 fluphenazine 10.66 µM -0.17619052575243 0.426675769563799 no 1958 0.43007213185485 620 3372 An atypical antipsychotic.
SGTC_3306 9127676 59.7925 µM -0.178108101498658 0.425924804845237 no 1959 0.429319039843179 618 41905287
SGTC_299 1273-0059 1.44 µM -0.178267766298267 0.425862288682589 no 1960 0.429256346039925 635 2848077
SGTC_1291 0993-0025 5.79 µM -0.178370920786233 0.425821899914504 no 1961 0.429215842461762 633 4353356
SGTC_2650 prasterone 100 µM -0.178935958691842 0.425600680652825 no 1962 0.428993993733225 611 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_800 3448-7362 155 µM -0.179841735944494 0.425246106648095 no 1963 0.428638408608155 627 15991913
SGTC_772 k072-0172 35.3 µM -0.180805780061621 0.424868790017224 no 1964 0.428260013027266 619 5861980
SGTC_390 dec-rvkr-cmk 16.7 µM -0.181139470330798 0.424738203205341 no 1965 0.428129052083218 637 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_265 mycophenolic acid 32.932 µM -0.181953545785373 0.424419656471762 no 1966 0.427809591169503 633 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2839 9003951 25.97 µM -0.182100640819294 0.424362103623531 no 1967 0.42775187292025 623 2990634
SGTC_651 3253-0966 34.4 µM -0.182554049248834 0.424184711821377 no 1968 0.427573970863143 630 781462
SGTC_1717 st033143 58.0435 µM -0.18373923973602 0.423721089773955 no 1969 0.427109012038335 647 674616
SGTC_39 0986-0283 58.349 µM -0.184177126556964 0.423549824164136 no 1970 0.426937251441254 612 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1374 2889-5571 141 µM -0.184404649076083 0.423460841611026 no 1971 0.426848011463732 614 2853281
SGTC_578 3460-0051 92 µM -0.184844858329329 0.4232886897682 no 1972 0.426675361105528 651 2876744
SGTC_2198 6589944 200 µM -0.186125072666992 0.422788121979969 no 1973 0.42617334015204 633 5290268
SGTC_1641 st009299 47.1 µM -0.186336324314333 0.422705533888208 no 1974 0.426090511785586 634 4046054
SGTC_1219 1469-0211 33.1 µM -0.18673300506421 0.422550462120282 no 1975 0.425934988468326 653 6822282
SGTC_3259 9138485 49.47 µM -0.186913544824991 0.422479888885098 no 1976 0.425864209561346 622 17646153
SGTC_1456 k015-0012 13 µM -0.187034358503131 0.422432664045531 no 1977 0.425816847034383 651 2989616
SGTC_1733 st037357 54.9 µM -0.189856695958272 0.421329759674059 no 1978 0.424710713408647 681 1272339 YGL099W LSG1
SGTC_1799 st045822 46.1415 µM -0.190277798331733 0.421165255265369 no 1979 0.424545725093856 625 3674992
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.190902408731062 0.420921275428558 no 1980 0.424301026493244 619 688664
SGTC_519 k048-0011 62.8 µM -0.193926149773531 0.419740599212721 no 1981 0.423116853904858 629 6836379
SGTC_2596 sinensetin 100 µM -0.194077194640192 0.419681639769264 no 1982 0.423057719076429 636 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_564 3555-0129 330 µM -0.194439449007892 0.419540243333475 no 1983 0.422915901727852 628 563260
SGTC_358 0075-0058 9.45 µM -0.195131901762552 0.419269991590082 no 1984 0.422644844294579 723 1069125
SGTC_1884 5633444 25 µM -0.195283541967735 0.419210814248424 no 1985 0.422585490320297 638 5724239
SGTC_2223 6903751 107.57 µM -0.195311730886491 0.419199813770457 no 1986 0.42257445699978 648 5598863
SGTC_1775 st081588 35.1725 µM -0.195737519063767 0.419033661360893 no 1987 0.422407808216078 643 1426443 YGL099W LSG1
SGTC_122 0236-0016 402.397 µM -0.196307354504285 0.418811320970503 no 1988 0.422184802662692 635 6808838
SGTC_1481 3346-2004 36 µM -0.196680244719767 0.418665839390551 no 1989 0.422038885278122 640 2770522
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.198724201118407 0.417868596330275 no 1990 0.42123924591114 655 23847180
SGTC_2662 daunorubicin 22.37 µM -0.200751262542713 0.41707827634199 no 1991 0.420446536929108 611 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2988 9073640 71.4286 µM -0.201768387438106 0.416681841030373 no 1992 0.420048898205655 659 9102229
SGTC_1072 oxiconazole 14.9 nM -0.204057064378638 0.415790115083553 no 1993 0.419154452999463 633 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1867 st057372 64 µM -0.204402160988125 0.415655694279749 no 1994 0.419019620805171 644 688837
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.205287165931018 0.415311015445337 no 1995 0.418673885316999 706 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3194 9111903 49.47 µM -0.20625429564772 0.414934426371473 no 1996 0.418296138844644 662 17087251
SGTC_1795 st049545 62.3 µM -0.207941107126139 0.414277788803744 no 1997 0.417637475891909 617 5291882
SGTC_1718 roemerine 11.9335 µM -0.208806685618971 0.413940931543724 no 1998 0.417299576005407 650 235224 An aporphine alkaloid with mutagenic activity.
SGTC_903 1134-0042 114 µM -0.209571536072173 0.413643327302532 no 1999 0.417001048602651 633 701009
SGTC_3113 9123498 49.47 µM -0.210382999486233 0.413327640128083 no 2000 0.416684380093058 628 8897275
SGTC_197 4544-0043 41.561 µM -0.210929898719214 0.413114909109267 no 2001 0.416470986577309 634 896523
SGTC_3309 9129340 25.759 µM -0.211123654578278 0.413039548725013 no 2002 0.4163953912689 629 17158987
SGTC_1843 st055809 45.5 µM -0.214640832872188 0.411672119295619 no 2003 0.415023677894131 641 16413835
SGTC_118 0083-0097 135.343 µM -0.215110672324734 0.411489533137695 no 2004 0.414840516681292 647 5207356
SGTC_1011 4112-3381 17.4 µM -0.216598602943265 0.41091142921025 no 2005 0.414260587292001 682 2877139
SGTC_2941 9056145 11.23 µM -0.216867021303289 0.410807161501586 no 2006 0.41415598957596 655 2119517
SGTC_1119 parthenolide 318.541 nM -0.217187844410073 0.410682545321026 no 2007 0.414030978678719 691 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2265 7929201 200 µM -0.217712572178391 0.410478746613075 no 2008 0.413826533727738 682 1265108
SGTC_2853 9015042 58.44 µM -0.218119972604994 0.410320533266925 no 2009 0.413667818073954 630 6457456
SGTC_1759 st043059 70 µM -0.218389832067078 0.410215741782452 no 2010 0.413562693593575 678 669426
SGTC_766 1391-0721 126 µM -0.218417609309065 0.410204955722807 no 2011 0.413551873245678 685 1020919 YIL115C NUP159
SGTC_1260 0700-1617 7.75 µM -0.218420512106406 0.410203828554156 no 2012 0.41355074249368 620 2853078
SGTC_1168 k815-0004 80.5 µM -0.220286388371674 0.409479454697432 no 2013 0.412824060158025 635 642433
SGTC_183 3914-0051 30.55 µM -0.220619624080437 0.409350117770123 no 2014 0.412694309866078 624 1596232
SGTC_2376 9072922 81.32 µM -0.220762505960344 0.409294664839945 no 2015 0.412638679596656 686 17087968
SGTC_1634 st006576 41 µM -0.221526591483731 0.408998151551919 no 2016 0.412341216934291 641 3915356
SGTC_516 3992-2719 87.3 µM -0.221776277643465 0.408901268881444 no 2017 0.412244023656235 641 5350887 YDR037W KRS1
SGTC_2945 9067681 61.76 µM -0.221990923633433 0.408817986868605 no 2018 0.412160474478648 669 16456930
SGTC_2936 9038235 15.59 µM -0.225981944468044 0.407270236274539 no 2019 0.410607731669277 635 4749415
SGTC_2045 5106652 78.05 µM -0.227658822823101 0.406620359320703 no 2020 0.409955743227523 630 673349
SGTC_276 colchicine 750 µM -0.230158715860622 0.405651999505826 no 2021 0.408984220334986 694 2833 A microtubule depolymerizer.
SGTC_12 0849-0099 9.267 µM -0.231080998625595 0.405294889007692 no 2022 0.408625938280813 632 6071388
SGTC_2679 rapamycin 1 nM -0.231513424516572 0.405127479605014 no 2023 0.408457978723402 664 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1187 1391-0724 117 µM -0.232056909297336 0.404917099474248 no 2024 0.408246906370964 656 6997986
SGTC_1323 1348-1351 11.2 µM -0.232148193249941 0.40488176662477 no 2025 0.408211457171312 633 6989654
SGTC_1895 st058434 18.3 µM -0.233606966405205 0.404317231572794 no 2026 0.407645059485732 698 5393175
SGTC_2792 7535235 81.82 µM -0.235756740617726 0.403485647266053 no 2027 0.406810718982053 638 1281891
SGTC_969 1313-0238 134 µM -0.236177550197128 0.403322918940907 no 2028 0.406647449575255 646 5212874
SGTC_359 0081-0058 15.9 µM -0.236383353044561 0.403243340456346 no 2029 0.406567606280474 657 3494159
SGTC_3228 9131799 49.47 µM -0.237330950075206 0.402876981645749 no 2030 0.406200026599149 649 17015818
SGTC_2318 6029776 164 µM -0.238082478703651 0.402586487164584 no 2031 0.405908562013866 683 818325
SGTC_2771 fluoxetine 41.05 µM -0.238301373468045 0.40250188609451 no 2032 0.405823678078719 667 3386 A selective serotonin reuptake inhibitor.
SGTC_1166 k206-0078 225 µM -0.23926617885238 0.402129051020586 no 2033 0.405449594594973 647 5404595
SGTC_1430 4049-0248 69.1 µM -0.239497508351685 0.402039670304328 no 2034 0.405359914151011 663 22774488
SGTC_3290 9121031 71.43 µM -0.239518253923267 0.402031654914302 no 2035 0.405351871873944 638 17014854
SGTC_2276 7947513 42.08 µM -0.239550320846283 0.402019265416516 no 2036 0.405339440813781 677 2105100
SGTC_86 0417-1630 471.922 µM -0.240676816687215 0.401584090783715 no 2037 0.404902804234888 640 3634867
SGTC_2772 vinpocetine 57.06 µM -0.24125049063963 0.401362522663489 no 2038 0.404680490207428 643 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_923 1900-2434 73.3 µM -0.241312700888765 0.401338497317345 no 2039 0.404656383916864 665 5910570
SGTC_1386 3228-0095 33.8 µM -0.241722060778603 0.40118041349351 no 2040 0.404497767179908 690 870181
SGTC_2991 9074669 71.4286 µM -0.243236515262475 0.400595712554942 no 2041 0.403911090509684 686 17333109
SGTC_1849 st056239 19.2 µM -0.243326659619642 0.400560916609054 no 2042 0.403876176755476 664 5393181
SGTC_2481 5478948 45.16 µM -0.243466635929246 0.400506886969792 no 2043 0.403821964137077 648 77792
SGTC_1514 1189-1591 158 µM -0.244004275823014 0.400299380349256 no 2044 0.40361375418349 708 767698 YMR146C TIF34
SGTC_2636 apigenin dimethyl ether 100 µM -0.245463310573796 0.399736395632267 no 2045 0.403048856606471 698 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_80 0159-0065 512.242 µM -0.246326456135702 0.399403439379457 no 2046 0.40271476586494 649 1548079
SGTC_2953 9074162 66.49 µM -0.246344476137619 0.399396488987305 no 2047 0.402707791765238 638 16451992
SGTC_126 0417-1624 672.48 µM -0.248806718014034 0.398447092453633 no 2048 0.401755147135874 684 41912 YDL195W SEC31
SGTC_1727 st034309 9.9045 µM -0.249237303474459 0.398281127939456 no 2049 0.401588612835385 692 870305
SGTC_3130 9127414 49.47 µM -0.249852255092684 0.398044133390407 no 2050 0.401350803617011 656 1494646
SGTC_323 4013-0906 34.3 µM -0.249950846662463 0.398006140946839 no 2051 0.401312680462305 658 2910086
SGTC_1354 1498-1681 81 µM -0.250448040967865 0.397814560945431 no 2052 0.401120440867719 676 5754243
SGTC_223 busulfan 5 mM -0.250865782111586 0.397653615056077 no 2053 0.400958940247401 661 2478 A DNA alkylator.
SGTC_2709 st078560 56 µM -0.2515671285476 0.397383441868524 no 2054 0.400687834607129 673 17250903
SGTC_1772 st048439 82.2 µM -0.253867512202018 0.396497632552263 no 2055 0.399798957105432 648 2927068 YDL195W SEC31
SGTC_978 1416-0512 87.4 µM -0.255151709115487 0.396003358465456 no 2056 0.399302963683965 667 6814003
SGTC_3244 9134489 49.47 µM -0.255263811281926 0.39596021942441 no 2057 0.399259674335031 699 16584271
SGTC_788 1182-0090 188 µM -0.255669097152077 0.395804268364528 no 2058 0.399103179567343 648 5715185
SGTC_873 0591-4978 488 µM -0.256366650299993 0.395535894047668 no 2059 0.398833868369422 657 3305145
SGTC_2644 guaiazulene 100 µM -0.257087544177286 0.395258591737225 no 2060 0.398555596388636 669 3515 A coloring agent.
SGTC_629 3448-6466 76.7 µM -0.257909283757591 0.394942562346049 no 2061 0.398238459896266 691 573744
SGTC_2302 7771753 200 µM -0.261429931285702 0.39358935593597 no 2062 0.3968804887765 646 2203047
SGTC_264 promethazine 12.5 mM -0.262258613766416 0.393271027211092 no 2063 0.396561033496422 654 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_580 1123-0028 41 µM -0.262687919261573 0.393106142543412 no 2064 0.39639556445321 669 1677248 YPR107C YTH1
SGTC_507 nimesulide 162 µM -0.263737546306637 0.392703089896644 no 2065 0.395991080875131 678 4495 A COX2 inhibitor.
SGTC_910 3454-3003 490 µM -0.265525153433907 0.392016920801323 no 2066 0.39530246770862 691 820824
SGTC_1848 st056003 16.4 µM -0.266431128465812 0.391669292302682 no 2067 0.394953597137739 637 146492
SGTC_2552 juarezic acid 87.02 µM -0.267006803173932 0.391448447099294 no 2068 0.394731961511778 654 1549512
SGTC_2766 oltipraz 83.91 µM -0.267107818471789 0.391409698361973 no 2069 0.39469307398184 670 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_561 1550-0330 72.9 µM -0.267121139480682 0.391404588599763 no 2070 0.394687945914767 687 6812934
SGTC_2624 nerol 100 µM -0.268661012014455 0.390814040439027 no 2071 0.394095278444946 668 637566 A natural product oil.
SGTC_789 1309-1135 70.6 µM -0.269480824900998 0.39049974103885 no 2072 0.393779848066115 651 3092424
SGTC_3068 9116768 49.47 µM -0.26954613373267 0.390474706049825 no 2073 0.393754722899855 684 41904888
SGTC_381 3461-2219 42.7 µM -0.270225916364603 0.390214150344555 no 2074 0.393493227862993 710 2883159
SGTC_1049 3226-0134 66 µM -0.270913513324383 0.389950649626253 no 2075 0.393228775716249 660 5702385
SGTC_2782 7736369 71.43 µM -0.271990704282376 0.389537950498162 no 2076 0.392814583454977 667 2950836 YOL077C BRX1
SGTC_748 act1.228 77.9 µM -0.273079575523374 0.389120902925058 no 2077 0.392396023308088 662 4421505 YNR035C ARC35
SGTC_2038 4100038 30.985 µM -0.273513458296527 0.388954757438545 no 2078 0.392229274196641 667 3596803
SGTC_1502 4534-4282 27.7 µM -0.27479996199398 0.388462239738606 no 2079 0.391734963649351 699 3278949
SGTC_1714 st033236 13.627 µM -0.27531371070006 0.388265609175139 no 2080 0.391537615865552 692 2916566
SGTC_1642 st009582 77.7 µM -0.275385488785862 0.388238139335171 no 2081 0.391510045761934 696 6739311
SGTC_2167 5876490 200 µM -0.277688573649485 0.387357034479784 no 2082 0.390625716336722 675 686534
SGTC_2894 9048625 32.47 µM -0.277856729828584 0.387292724635025 no 2083 0.390561170486479 670 4092861
SGTC_2704 st078022 71.1 µM -0.280007118745005 0.38647060065447 no 2084 0.389736021651548 710 54697681
SGTC_893 0958-0369 48.9 µM -0.281439393149144 0.385923304329052 no 2085 0.389186703619569 708 6819948
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.281561588927171 0.385876621744375 no 2086 0.389139848292855 656 16623 A steroid.
SGTC_1118 chelidonine 707.474 nM -0.281575562920841 0.385871283349814 no 2087 0.389134490141375 660 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3078 9116413 49.47 µM -0.282235599971731 0.385619158294468 no 2088 0.388881431298348 655 17177322
SGTC_3229 9132204 49.47 µM -0.282332217358083 0.38558225583653 no 2089 0.388844392051657 661 17682924
SGTC_1288 0973-0013 65.5 µM -0.283451357382091 0.385154882266224 no 2090 0.388415432181949 663 4315430
SGTC_609 0986-0026 86.3 µM -0.283544309648241 0.385119392220996 no 2091 0.388379810230917 670 2848610
SGTC_159 3970-0959 50 µM -0.285541482610555 0.384357085801365 no 2092 0.387614664032258 673 6615653
SGTC_1101 ebselen 5.29 µM -0.285936305916992 0.38420643744233 no 2093 0.387463452997494 695 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1652 st011932 78 µM -0.286078632662192 0.384152135689352 no 2094 0.387408948306752 675 1551076
SGTC_544 k015-0020 52.4 µM -0.28629624434022 0.384069114962458 no 2095 0.387325617190743 641 3008304
SGTC_2739 tacrine 100.86 µM -0.286533077899495 0.383978766967464 no 2096 0.387234931244403 677 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_692 k241-0027 77.8 µM -0.289478311379389 0.382855738454948 no 2097 0.386107687386759 688 3600480
SGTC_1478 0453-0656 35.7 µM -0.292479260353288 0.381712477521946 no 2098 0.384960107406956 686 5258496
SGTC_1259 0671-0132 43 µM -0.293238375648614 0.381423443047056 no 2099 0.384669976573436 675 X1259
SGTC_222 nsc-310342 10.666 µM -0.293288012647345 0.381404545974338 no 2100 0.384651007758454 691 432556
SGTC_3084 9116877 49.47 µM -0.294800700406287 0.38082879339132 no 2101 0.384073065677183 691 27241325
SGTC_2174 5790901 200 µM -0.295036391757348 0.380739109302643 no 2102 0.383983039894384 680 786020
SGTC_875 0709-0210 25.7 µM -0.295169437991991 0.380688486047177 no 2103 0.383932223689493 713 6251364
SGTC_2093 5331342 194.4 µM -0.295604425052766 0.38052299046744 no 2104 0.383766096943807 678 33839
SGTC_1392 3455-1037 33.9 µM -0.29637298387176 0.380230637326191 no 2105 0.383472627394044 677 981132
SGTC_2128 5255449 168.493 µM -0.296440277802144 0.380205042550729 no 2106 0.383446934792666 658 736008
SGTC_392 N-ethylmaleimide 8.33 µM -0.296761785791243 0.380082766478877 no 2107 0.383324191175134 654 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2285 7945142 200 µM -0.297315631651424 0.379872155669478 no 2108 0.383112774304364 712 2970608
SGTC_2507 purpurin 79.67 µM -0.297904434999496 0.379648290655471 no 2109 0.382888051459722 655 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_120 rhodamine 6G 52.259 µM -0.298344152195489 0.37948113500188 no 2110 0.382720254580421 688 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2778 tioconazole 65.09 nM -0.298601370116307 0.379383365709057 no 2111 0.382622109957372 697 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_354 2783-3500 4.88 µM -0.299370305013057 0.379091137295399 no 2112 0.382328758476022 675 6740761
SGTC_2391 6285546 200 µM -0.301101215027039 0.378433569888106 no 2113 0.381668657269651 665 846083
SGTC_1195 1502-0147 41.1 µM -0.30146715655519 0.37829459481944 no 2114 0.381529145503496 673 817940
SGTC_1148 3909-7663 27.7 µM -0.302257324888231 0.377994563170299 no 2115 0.38122795377325 714 4084526
SGTC_2899 9053889 58.44 µM -0.302785757060349 0.377793955350829 no 2116 0.381026569221795 696 6470052
SGTC_2701 st077767 14.721 µM -0.303955417294526 0.377350036467378 no 2117 0.380580928466549 694 5721188
SGTC_3136 9095672 49.47 µM -0.30409745605263 0.377296139792491 no 2118 0.380526822449871 644 17217380
SGTC_23 0213-0011 39.996 µM -0.305089570249169 0.37691974828566 no 2119 0.380148967253592 695 627608
SGTC_908 3448-7491 47.7 µM -0.30597089474419 0.376585486600395 no 2120 0.379813403165808 666 1203031
SGTC_376 3970-0862 59.1 µM -0.306491773671602 0.376387975297804 no 2121 0.379615121163544 706 3135186
SGTC_906 1165-0455 526 µM -0.306589569891562 0.376350895702135 no 2122 0.37957789678811 705 3252859
SGTC_3148 9097893 49.47 µM -0.307142720908109 0.376141189085125 no 2123 0.379367370803071 674 17174100
SGTC_876 0720-0963 56.8 µM -0.307239361933629 0.376104554988172 no 2124 0.379330593472276 729 765861
SGTC_426 0988-0037 14.6 µM -0.310749962937418 0.374774536839546 no 2125 0.377995355675954 717 5383008
SGTC_1802 st050112 57.9 µM -0.311725898128226 0.37440505997101 no 2126 0.37762442206974 671 4662563
SGTC_3343 9148379 18.9835 µM -0.312027439383066 0.374290923521169 no 2127 0.37750983502229 701 1955036
SGTC_820 1582-0060 59.9 µM -0.31382937889383 0.373609100917723 no 2128 0.376825314846237 686 3848840
SGTC_1370 2001-0092 44.6 µM -0.314457549564348 0.373371504889628 no 2129 0.376586776449064 695 790957
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.314541804294968 0.373339640474837 no 2130 0.376554785559518 681 688803
SGTC_2754 granisetron 64.02 µM -0.314853896252182 0.373221617527246 no 2131 0.376436293971164 717 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1980 st071811 45.7 µM -0.315288048381201 0.373057455207579 no 2132 0.376271479305978 712 4974850
SGTC_3091 9116372 49.47 µM -0.317212127397865 0.37233019702781 no 2133 0.3755413242126 690 17169793
SGTC_2773 thioridazine 9.09 µM -0.318725482401653 0.371758502769748 no 2134 0.374967344746394 683 5452 An antipsychotic.
SGTC_2784 7567673 72.73 µM -0.319036557824262 0.371641023996286 no 2135 0.374849395512591 688 3471247
SGTC_14 0354-0009 295 µM -0.319608646240606 0.371425003921503 no 2136 0.374632509582851 686 1713507
SGTC_2345 9052315 157.45 µM -0.319821743828691 0.371344548809453 no 2137 0.374551731733767 672 6469265
SGTC_1280 0880-0253 10.1 µM -0.320997344754291 0.370900801163776 no 2138 0.374106201549201 708 6836607
SGTC_2151 5563267 85.4165 µM -0.321651816587999 0.370653835597088 no 2139 0.37385824209112 701 5310824
SGTC_1606 st000094 49.2 µM -0.323313788476415 0.370026928611654 no 2140 0.373228806301764 703 1242210
SGTC_3179 9107801 49.47 µM -0.324613180010489 0.369537029717542 no 2141 0.372736925400083 673 4818259
SGTC_188 3229-0966 278.469 µM -0.326429126818824 0.368852733096067 no 2142 0.372049851674681 693 5722370
SGTC_2282 7944268 200 µM -0.327063569222831 0.368613756315173 no 2143 0.37180990268133 731 2970414
SGTC_1175 0741-0056 27.6 µM -0.327436064534482 0.368473471371495 no 2144 0.371669046455967 691 765927
SGTC_1463 k081-0032 34.1 µM -0.327713093340867 0.368369151301465 no 2145 0.371564301290308 696 977755
SGTC_504 lovastatin 124 µM -0.327833766024884 0.368323712912971 no 2146 0.37151867767121 732 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_361 000s-0510 1.45 µM -0.328740579288806 0.367982318179997 no 2147 0.371175889819368 685 660
SGTC_1991 st073000 8.92 µM -0.328744999112616 0.36798065447114 no 2148 0.371174219315348 714 4301969 YIL048W NEO1
SGTC_3083 9117465 49.47 µM -0.329114319376719 0.367841643791301 no 2149 0.371034640658131 736 16420915
SGTC_1188 1403-0014 4.57 µM -0.329407859595647 0.367731168763825 no 2150 0.370923713950338 699 9614867
SGTC_1974 st069448 26.9 µM -0.330554335148247 0.367299793041453 no 2151 0.370490572030283 688 6323587 YNR016C ACC1
SGTC_574 1315-0397 40 µM -0.331183462249707 0.367063147235615 no 2152 0.370252955622025 684 6794277
SGTC_3062 9077494 49.47 µM -0.333643833032375 0.366138165811413 no 2153 0.369324168868739 658 16459633
SGTC_414 piperonyl butoxide 100 µM -0.333832205249043 0.366067378860859 no 2154 0.369253089948376 699 5794 A potent inhibitor of cytochrome P450.
SGTC_2065 5221596 34.26 µM -0.334371070271184 0.365864908085207 no 2155 0.369049783462995 687 788581
SGTC_1910 st062352 60.4 µM -0.335477525164441 0.36544929073309 no 2156 0.368632447872161 668 2245730
SGTC_576 1073-0113 22.7 µM -0.335681735937664 0.365372600346339 no 2157 0.36855544002841 719 5439563
SGTC_2855 9016525 58.44 µM -0.337208899131812 0.364799252286405 no 2158 0.367979714619332 686 43811474
SGTC_489 paxilline 115 µM -0.338084335846207 0.364470720303767 no 2159 0.36764981722384 723 105008 A toxic potassium channel blocker.
SGTC_883 0850-0245 24.6 µM -0.338405629491281 0.364350170879369 no 2160 0.367528766203071 695 6823229 YPR165W RHO1
SGTC_186 3455-3465 67.277 µM -0.339069961178012 0.364100956092712 no 2161 0.367278513465749 695 755278
SGTC_3056 9094900 49.47 µM -0.339535949666839 0.363926181276627 no 2162 0.367103009938192 699 25236784
SGTC_1807 st050092 58.9 µM -0.340180946690849 0.363684313775594 no 2163 0.366860132906725 718 5008496
SGTC_1530 rhein 70.4 µM -0.340695584065694 0.363491368805104 no 2164 0.366666381703791 679 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_686 1319-0111 510 µM -0.341057469074228 0.363355713628593 no 2165 0.366530159205717 742 4562600
SGTC_1161 k007-0610 110 µM -0.341158584163649 0.363317812978216 no 2166 0.366492099981031 715 5843850
SGTC_635 k038-0028 24.7 µM -0.341584175888851 0.363158304445268 no 2167 0.366331923735149 713 4035102
SGTC_3153 9100258 49.47 µM -0.343257734658422 0.362531297749717 no 2168 0.365702287060406 726 25236848
SGTC_2365 9042475 200 µM -0.343853288213548 0.362308259613574 no 2169 0.365478311357493 689 6464479
SGTC_2108 5365811 200 µM -0.344953525789902 0.3618963374554 no 2170 0.365064654831163 673 780283
SGTC_2026 5148700 152 µM -0.345561987239919 0.361668601895311 no 2171 0.364835958844606 679 79838
SGTC_2398 5228213 48.84 µM -0.346004178309128 0.361503128911605 no 2172 0.36466978731572 708 80771 YMR134W ERG29
SGTC_2896 9052656 71.43 µM -0.347230915265213 0.361044205516167 no 2173 0.364208923498619 723 6469436
SGTC_401 neomycin 50 µM -0.347773684527138 0.360841218814343 no 2174 0.364005077086317 701 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2266 7929956 200 µM -0.350849133995488 0.35969179344221 no 2175 0.362850766870751 702 2967153
SGTC_1885 st057546 99.9 µM -0.350929016777688 0.359661954723806 no 2176 0.362820800965833 693 702008
SGTC_135 0933-0004 26.348 µM -0.350951737487779 0.359653467983993 no 2177 0.362812278048093 696 21230617 YGL099W LSG1
SGTC_1459 k035-0031 35.7 µM -0.351533897105019 0.359436040773021 no 2178 0.362593923444639 679 3877128 YMR208W ERG12
SGTC_1231 0242-0792 125 µM -0.352492255090425 0.359078208687339 no 2179 0.362234562888715 724 3707635
SGTC_2588 indole-3-carbinol 100 µM -0.354233036665986 0.358428551312811 no 2180 0.361582123496584 715 3712 Induces cell cycle arrest.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.354303445732994 0.358402283347259 no 2181 0.361555742853601 747 6728940
SGTC_3003 9075612 71.4286 µM -0.354793070975127 0.358219634231058 no 2182 0.361372309847618 736 6501993
SGTC_938 3126-1755 342 µM -0.355370084597606 0.358004427518751 no 2183 0.36115617859663 712 1777771
SGTC_192 3455-0609 60.9 µM -0.356790014977487 0.357475033384987 no 2184 0.360624505928954 698 3769639
SGTC_1761 st044296 37 µM -0.359602600572741 0.356427224275051 no 2185 0.359572169268083 703 1826700
SGTC_2393 9031399 185.94 µM -0.360041695595918 0.356263740016602 no 2186 0.359407976473511 728 1526623 YDL150W RPC53
SGTC_1920 st075728 45.7 µM -0.36045955539374 0.356108186605683 no 2187 0.359251748365787 724 3400306
SGTC_2601 securinine 100 µM -0.360786938936848 0.35598633081332 no 2188 0.359129363673654 699 442872 A GABA receptor antagonist.
SGTC_2951 9072950 58.06 µM -0.362375997518271 0.355395074732719 no 2189 0.35853553679372 707 16488155
SGTC_165 k038-0023 64.381 µM -0.362741653364283 0.355259070880364 no 2190 0.358398940530572 705 46368543
SGTC_2140 5586273 200 µM -0.363453714835848 0.35499427611258 no 2191 0.358132991220095 689 854421
SGTC_1614 st002383 48.6 µM -0.364533325091156 0.354592934334615 no 2192 0.357729896664518 705 1947235
SGTC_2676 harmalol 100 µM -0.366329082907139 0.353925724526181 no 2193 0.357059765298814 692 5459187 A monoamine oxidase inhibitor
SGTC_2493 resveratrol 26.09 µM -0.366521776648434 0.353854156196376 no 2194 0.356987883020065 698 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3318 9139014 38.6185 µM -0.366983194545816 0.353682802093146 no 2195 0.35681577679039 731 16643984
SGTC_1367 1812-0510 76.9 µM -0.367009810218674 0.353672918888125 no 2196 0.356805850185673 695 1142582 YDR527W RBA50
SGTC_1081 sertraline 6 µM -0.367133361258898 0.353627041938533 no 2197 0.356759771751113 711 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_95 0471-0001 561.058 µM -0.367169159982697 0.353613749560184 no 2198 0.356746420986103 685 4015405
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.368033568625608 0.3532928413171 no 2199 0.356424102004378 736 229346 A bile salt which induces apoptosis.
SGTC_27 0485-0001 32.618 µM -0.368138140160896 0.353254026620215 no 2200 0.356385116524978 694 2054479
SGTC_2777 climbazole 1.536 µM -0.370417105739769 0.352408503533105 no 2201 0.355535865151759 711 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2651 TUB2.036 5 µM -0.370548103067375 0.352359924093063 no 2202 0.355487071036866 700 15992207 YFL037W TUB2
SGTC_2641 levomentholum 100 µM -0.37181985752263 0.351888428173673 no 2203 0.355013488920398 704 16666
SGTC_2319 6033012 152.6 µM -0.372330316446022 0.351699242345063 no 2204 0.354823464670863 686 847246
SGTC_2801 7907800 81.82 µM -0.372818515414399 0.351518340832106 no 2205 0.354641760731568 740 6620925
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.373122621413592 0.351405671729932 no 2206 0.354528591506754 703 5355888
SGTC_1695 st026914 34.495 µM -0.373918767674769 0.351110767073922 no 2207 0.354232376518129 711 3289191
SGTC_2665 lovastatin 100 µM -0.374146331555913 0.351026490424703 no 2208 0.354147725064042 713 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1130 3454-2858 15.9 µM -0.374234510228096 0.35099383605615 no 2209 0.354114925430175 755 715628 YIL048W NEO1
SGTC_1679 SEC14.276 6.7 µM -0.375123371738095 0.350664733919211 no 2210 0.353784357979348 688 1005053 YMR079W SEC14
SGTC_3029 9088683 49.47 µM -0.376126097574091 0.350293607855545 no 2211 0.35341157669941 707 25236615
SGTC_1371 2421-0008 32.7 µM -0.379372710844911 0.349092962411924 no 2212 0.352205556114895 725 2827552
SGTC_816 0325-0417 81.3 µM -0.379603582140492 0.34900764013447 no 2213 0.352119850680839 703 68101
SGTC_1930 st074634 34.3 µM -0.38138224816081 0.348350561124362 no 2214 0.351459815683188 741 684253 YOR116C RPO31
SGTC_954 1189-0853 2.85 µM -0.381784505545901 0.348202021246911 no 2215 0.351310606286025 717 2828194
SGTC_3283 9109332 35.8195 µM -0.382525311245033 0.347928528006215 no 2216 0.351035879077379 704 17027281
SGTC_1085 doxorubicin 7.67 µM -0.383911437906991 0.34741700545772 no 2217 0.350522044284346 729 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1422 4031-0024 15.5 µM -0.384217419057682 0.347304126575395 no 2218 0.350408654395709 730 782427
SGTC_3224 9130643 49.47 µM -0.386293812657917 0.346538486663643 no 2219 0.349639541174165 750 17644395
SGTC_2558 carylophyllene oxide 100 µM -0.390253682490813 0.345080081068644 no 2220 0.348174484664825 741 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2461 5755302 26.15 µM -0.390327946220261 0.345052751895871 no 2221 0.34814703042326 755 2788904
SGTC_2475 5812728 15.03 µM -0.391299229765846 0.344695392431395 no 2222 0.34778803406552 715 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_467 ro 31-8220 72.8 µM -0.391894695760137 0.344476374104976 no 2223 0.347568011162325 711 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_21 0849-0113 22.993 µM -0.393633994232349 0.343836941552897 no 2224 0.3469256398023 716 1560156
SGTC_206 4546-0025 72.014 µM -0.394786826788964 0.34341336216172 no 2225 0.346500108810407 754 6620745 YIL048W NEO1
SGTC_1109 tnp00067 928.257 nM -0.396297883297711 0.342858460137732 no 2226 0.345942644285395 732 676295
SGTC_2515 chrysin 20.77 µM -0.397619521391661 0.342373395537391 no 2227 0.345455334258404 710 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2628 lathosterol 100 µM -0.397865700174974 0.342283072252167 no 2228 0.34536459229553 729 6710616
SGTC_269 exalamide 29 µM -0.398821893944997 0.341932329243982 no 2229 0.345012221814427 696 3316 A derivative of salicylamide.
SGTC_1026 k007-1105 30.6 µM -0.399101233103504 0.341829890114068 no 2230 0.344909306859699 680 7066794
SGTC_344 k064-0035 6.43 µM -0.399407139794537 0.341717721509455 no 2231 0.344796616978131 730 5088750
SGTC_665 3914-0008 307 µM -0.399784021516704 0.341579547286904 no 2232 0.34465780025122 738 1069549
SGTC_2616 abietic acid 100 µM -0.400474466092953 0.341326468190583 no 2233 0.344403543281414 737 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2967 9089538 49.85 µM -0.400678059848715 0.341251855506366 no 2234 0.344328583073681 727 728216
SGTC_971 1315-0384 26.7 µM -0.401096031495781 0.341098697437032 no 2235 0.344174711264288 734 6769120
SGTC_863 0466-0191 129 µM -0.403627194273586 0.340171759165213 no 2236 0.343243442535062 738 765160 YPR165W RHO1
SGTC_813 k007-0158 173 µM -0.404612425644923 0.339811217754689 no 2237 0.342881211752023 716 6523916
SGTC_1617 st002906 78 µM -0.405533938524278 0.339474126439873 no 2238 0.342542538410222 727 5150859
SGTC_604 1000-0114 314 µM -0.405774536356639 0.339386136382077 no 2239 0.342454134997106 742 1572745
SGTC_275 trichlorophene 5.69 µM -0.406369473005363 0.339168597170315 no 2240 0.342235573124313 723 62616
SGTC_286 k060-0067 22.9 µM -0.407000460912335 0.338937934351473 no 2241 0.342003824835821 712 5985051
SGTC_205 1486-1330 71.903 µM -0.408312114208333 0.33845864196921 no 2242 0.341522273298178 719 4118834
SGTC_685 1278-0033 54.9 µM -0.408892225324023 0.338246746435028 no 2243 0.341309377411236 713 3590572
SGTC_1263 0774-1208 64.8 µM -0.40914415751913 0.338154739828387 no 2244 0.341216936142673 769 906585
SGTC_860 0443-0016 25.1 µM -0.410457401934075 0.33767529452329 no 2245 0.340735222866447 728 5337942
SGTC_459 nigericin 15.3 µM -0.410883504897675 0.337519787437224 no 2246 0.340578979104309 774 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2965 9082772 38.63 µM -0.411173711005391 0.337413892046979 no 2247 0.340472581762627 702 16459634
SGTC_334 1502-1024 68.5 µM -0.411380951066318 0.337338278613256 no 2248 0.340396609768067 746 3296216
SGTC_51 1013-0126 23.419 µM -0.411964880506684 0.337125261948741 no 2249 0.340182582310231 749 1627850
SGTC_33 0986-0033 35.816 µM -0.413372432606327 0.336612003583103 no 2250 0.339666884444062 710 2848082
SGTC_1275 0867-0008 21.1 µM -0.413839792041525 0.336441650024 no 2251 0.339495719944245 733 3422836
SGTC_977 1348-1378 135 µM -0.416308539999542 0.3355423435778 no 2252 0.338592122120225 722 X977
SGTC_3144 9087057 49.47 µM -0.41882497137585 0.334626635796893 no 2253 0.337672026768761 777 17249618
SGTC_1366 1683-0113 21.9 µM -0.420288146420617 0.334094650406765 no 2254 0.337137484086452 727 708623
SGTC_273 hydroxyurea 18.1 mM -0.420601842992974 0.333980639038779 no 2255 0.337022923862823 730 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3221 9128209 49.47 µM -0.421305388330244 0.333724994915606 no 2256 0.336766048037975 732 16460723
SGTC_2760 etidronate 98.04 µM -0.424558386876236 0.332543972261578 no 2257 0.335579316864383 723 3305 A chelator and antioxidant.
SGTC_1379 2144-0755 36.5 µM -0.425225796593517 0.332301869626547 no 2258 0.335336040297155 740 5392327
SGTC_1019 4262-0212 3.4 µM -0.425898326962551 0.332057980242397 no 2259 0.335090967037212 741 4677213
SGTC_1818 st052136 56.3 µM -0.429117912862821 0.33089140221489 no 2260 0.333918708494492 729 674169
SGTC_1675 st018485 24.5 µM -0.432909125214992 0.329519805358302 no 2261 0.332540395198751 732 3323024
SGTC_1750 st081859 2.357 µM -0.433107661031191 0.32944804139286 no 2262 0.332468278700022 740 5291695
SGTC_2015 5119600 184 µM -0.43424698764427 0.329036334975817 no 2263 0.332054547665081 767 2828786
SGTC_1451 4152-0210 104 µM -0.43590192136566 0.328438678405112 no 2264 0.331453945522281 766 659563
SGTC_642 0335-0876 158 µM -0.436339513968714 0.328280721126516 no 2265 0.331295208455133 735 6812350
SGTC_3155 9099265 49.47 µM -0.436898165317222 0.328079110026352 no 2266 0.331092601276533 763 25236499
SGTC_177 1327-0068 8.361 µM -0.437894383170632 0.327719710311894 no 2267 0.330731423734008 715 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_522 1273-0010 11.6 µM -0.439776315956698 0.327041211935477 no 2268 0.330049561441004 744 5705015
SGTC_200 k038-0079 37.545 µM -0.442735464611639 0.325975497939621 no 2269 0.328978543649886 730 3436683
SGTC_2623 humulene 100 µM -0.443398699834851 0.325736833513117 no 2270 0.328738688081021 745 6187145 An anti-inflammatory.
SGTC_2158 5657123 3.6195 µM -0.443414123978884 0.325731284002003 no 2271 0.328733110858369 784 2858827
SGTC_1061 3448-9325 110 µM -0.44831723531918 0.323969137957262 no 2272 0.326962131801539 766 723482
SGTC_663 1486-0733 13.9 µM -0.449144320982764 0.323672275847083 no 2273 0.326663775008739 755 722445 YPR165W RHO1
SGTC_366 0181-0206 4.31 µM -0.449347709615591 0.323599291661718 no 2274 0.326590423060101 758 274874
SGTC_1686 st019653 115.5 µM -0.450503138923555 0.323184805046583 no 2275 0.326173845681283 768 97252
SGTC_1540 guanosine 70.6 µM -0.450725503218276 0.323105061568094 no 2276 0.32609369953183 742 6802 Guanosine is a purine nucleoside
SGTC_2478 5763493 32.33 µM -0.451011979849738 0.323002338338394 no 2277 0.32599045739005 722 1365576 YLR208W SEC13
SGTC_493 zm226600 134 µM -0.452564118565191 0.322446015762809 no 2278 0.325431320547819 767 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2336 9001819 198.65 µM -0.454864031386832 0.32162240442888 no 2279 0.32460353049866 763 2989602
SGTC_2785 7756463 72.73 µM -0.454894089969615 0.321611646076653 no 2280 0.324592717465033 750 2201551
SGTC_3317 9138495 8.753 µM -0.454968887525835 0.321584875721451 no 2281 0.324565811033446 757 17020139
SGTC_4 0960-0234 25.671 µM -0.455930291849698 0.321240867656604 no 2282 0.324220052958614 721 6821112
SGTC_1137 ixabepilone 100 µM -0.456938101858154 0.320880419379712 no 2283 0.323857768285553 723 154225 A novel microtubule stabilizer.
SGTC_174 3553-0389 74.3 µM -0.457397662045712 0.320716111388989 no 2284 0.323692622250763 721 738071
SGTC_1547 harmine 94.2 µM -0.459522900655465 0.319956725309942 no 2285 0.32292935535699 726 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_902 1120-0002 2.07 µM -0.460582108245835 0.319578532591629 no 2286 0.322549225232182 749 3280475
SGTC_2171 5739187 198.077 µM -0.463573772291204 0.318511365452286 no 2287 0.32147657447126 720 2262761
SGTC_1789 tunicamycin 25 nM -0.465732426276125 0.317742277711861 no 2288 0.320703519458031 756 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2278 7948257 134.34 µM -0.466327276995794 0.31753048155716 no 2289 0.320490628515711 762 1247028
SGTC_1503 4585-0012 61.3 µM -0.468417465344129 0.316786745473515 no 2290 0.319743040296304 760 2922052
SGTC_833 3852-0053 558 µM -0.469179376548145 0.31651582415221 no 2291 0.319470712768859 765 3123681
SGTC_1136 pergolide 1.05886 µM -0.470535662198993 0.316033798037155 no 2292 0.318986180773958 764 47811 A dopamine receptor agonist.
SGTC_745 0469-0705 296 µM -0.470600599288686 0.316010727125186 no 2293 0.318962989798035 760 3486736
SGTC_1317 1273-0028 910 nM -0.472679108276087 0.315272651366794 no 2294 0.318221066894885 740 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1635 st007035 42.4 µM -0.47348516315197 0.314986620427822 no 2295 0.317933541865083 748 3716403
SGTC_3303 9125618 40.5795 µM -0.474680015831259 0.31456282755179 no 2296 0.317507532024618 755 22695467
SGTC_1450 4112-4260 37.6 µM -0.475237311578639 0.31436524819225 no 2297 0.317308917744201 755 1633175
SGTC_584 0986-0246 15.4 µM -0.47525953895505 0.314357368970928 no 2298 0.317300997233908 772 53315 YDR232W HEM1
SGTC_2968 9090663 33.37 µM -0.476010532881221 0.314091204307754 no 2299 0.31703343701217 764 25236811
SGTC_164 4100-3994 89.624 µM -0.477657604009898 0.313507793710216 no 2300 0.31644696207688 784 4615967
SGTC_866 0495-0101 262 µM -0.477904823454975 0.313420266087123 no 2301 0.316358974080136 734 635694
SGTC_2765 myclobutanil 7.74 µM -0.478248926321206 0.313298454543945 no 2302 0.316236521560964 791 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1020 4335-0961 93.3 µM -0.481877764463295 0.312015097007261 no 2303 0.314946391336135 768 669075
SGTC_1800 st050079 29.0735 µM -0.483178237762086 0.311555731586105 no 2304 0.314484592983341 752 3645560
SGTC_3018 9082602 49.47 µM -0.483411659134631 0.31147331130242 no 2305 0.314401735691913 765 17332089
SGTC_2691 st077356 60.2 µM -0.488560732727345 0.309657599803956 no 2306 0.312576359414352 759 2839272
SGTC_1804 st050076 49.1 µM -0.488650401056944 0.309626021110379 no 2307 0.312544611996231 753 3895976
SGTC_1907 st060210 83.7 µM -0.491741769716952 0.308538187628074 no 2308 0.311450952960271 757 688793
SGTC_2076 5212012 200 µM -0.493619161319422 0.307878363631736 no 2309 0.310787582908485 758 604802
SGTC_527 4476-4215 268 µM -0.493981574135964 0.307751062218594 no 2310 0.310659596253527 731 4418754
SGTC_976 1348-1067 47.6 µM -0.494484246867751 0.307574531304981 no 2311 0.310482114518982 743 5310671 YGL099W LSG1
SGTC_2776 terbinafine 19.92 µM -0.494569406120881 0.307544629100246 no 2312 0.310452051189323 730 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.497428900362217 0.306541310349256 no 2313 0.309443314847902 774 688801
SGTC_1992 st073643 23.3 µM -0.499879508892836 0.305682610395243 no 2314 0.308579960744756 772 3161292
SGTC_1962 st076595 64.5 µM -0.500148428280359 0.305588445219144 no 2315 0.308485284214189 760 279619
SGTC_1068 loratadine 26.9 µM -0.500824860975813 0.305351641487245 no 2316 0.308247193687619 770 3957 A H1 histamine antagonist.
SGTC_2218 6965428 192.983 µM -0.5011149099081 0.305250126878746 no 2317 0.308145127072259 748 675684
SGTC_3204 9114183 49.47 µM -0.501413032506987 0.305145802165969 no 2318 0.308040234837533 726 17027248
SGTC_565 1418-0001 44.5 µM -0.501963165782321 0.304953330661853 no 2319 0.307846715672704 774 2862145
SGTC_115 0527-0192 112.043 µM -0.50309995748661 0.304555779803616 no 2320 0.307446998303386 787 4233931
SGTC_1202 1988-0068 29.6 µM -0.503236523028629 0.304508036572537 no 2321 0.307398994656351 752 2850480
SGTC_3339 9145883 14.936 µM -0.505122404566874 0.303849074374158 no 2322 0.30673643305247 775 2030670
SGTC_2030 5175110 200 µM -0.505493168483917 0.30371959739992 no 2323 0.306606247728952 800 2831986
SGTC_1952 st077036 64.1 µM -0.506258661447025 0.303452352358286 no 2324 0.306337539470372 770 2937007
SGTC_2390 9097792 176.6 µM -0.507981568501024 0.302851244391736 no 2325 0.305733134617139 742 4497149
SGTC_1618 st003135 44.5 µM -0.509794626221552 0.302219259963511 no 2326 0.305097675431372 792 1270615
SGTC_2496 diffractaic acid 79.83 µM -0.50991757874996 0.30217642337004 no 2327 0.305054602998812 749 94870 An apoptosis inducer which activates caspases.
SGTC_425 3825-7017 13.1 µM -0.510040492070486 0.302133603160783 no 2328 0.305011547000541 769 3397440
SGTC_2072 5231554 129 µM -0.510247960959536 0.302061331892128 no 2329 0.304938877679925 764 789545
SGTC_987 1497-1013 404 µM -0.512403474109287 0.30131092406048 no 2330 0.304184330035043 784 1676435
SGTC_525 k781-2675 26.7 µM -0.512535635568984 0.301264941461569 no 2331 0.304138093360772 758 3651118 YDL195W SEC31
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.513376747879869 0.300972369496976 no 2332 0.303843903714929 763 5106787 A p450 inhibitor.
SGTC_454 lyso-paf C-16 6.67 µM -0.51455198018232 0.300563792136454 no 2333 0.303433064122624 788 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2850 9015429 58.44 µM -0.514860342772771 0.300456629313805 no 2334 0.303325307350231 778 6457570
SGTC_418 lividomycin a 100 µM -0.516556065219124 0.299867636916184 no 2335 0.302733045972395 756 72394 An antibiotic.
SGTC_641 4092-0595 30 µM -0.516661653182126 0.299830979275107 no 2336 0.30269618462567 759 786260
SGTC_2882 9058044 58.44 µM -0.51711113596684 0.299674952200119 no 2337 0.302539290182519 763 18076804
SGTC_3116 9124943 49.47 µM -0.517337200254991 0.299596493355329 no 2338 0.302460394976573 734 41905195 YPL160W CDC60
SGTC_2075 5212009 200 µM -0.518752142799349 0.299105628906712 no 2339 0.301966797446106 787 780898
SGTC_2186 6124449 200 µM -0.518884785885245 0.299059631785131 no 2340 0.301920543946738 744 3834182 YLR033W RSC58
SGTC_1368 1852-0141 284 µM -0.521206557706029 0.298255023251141 no 2341 0.301111443200121 778 2838987
SGTC_534 k292-0788 63.4 µM -0.521496295997279 0.298154683851261 no 2342 0.30101054259943 782 4146317
SGTC_1765 st044815 90.4 µM -0.522156645689467 0.297926055326914 no 2343 0.300780634525126 771 645695
SGTC_1271 0832-2808 169 µM -0.522682062193593 0.297744200948189 no 2344 0.300597761555455 771 3663794
SGTC_3322 9139058 2.11 µM -0.522688623345915 0.297741930357044 no 2345 0.300595478241836 752 4908926 YPR165W RHO1
SGTC_1984 st072354 53.1 µM -0.523691879970011 0.297394830433774 no 2346 0.300246432133733 758 5762938
SGTC_1855 st056195 39.6 µM -0.523981102340852 0.297294801571557 no 2347 0.300145841920291 754 4028379
SGTC_729 4092-0585 94.1 µM -0.524297956273541 0.297185233859092 no 2348 0.300035659073627 752 2169061
SGTC_3112 9123419 49.47 µM -0.527967559420282 0.295917636555198 no 2349 0.298760926075552 792 17015854
SGTC_67 0335-0847 266 µM -0.528928330796133 0.295586166218717 no 2350 0.298427583971523 787 4552207 YOR254C SEC63
SGTC_1050 3232-1156 69.3 µM -0.529004786637263 0.295559795952296 no 2351 0.298401064692188 785 700529
SGTC_6 0844-0013 19.835 µM -0.529049454171941 0.295544390242287 no 2352 0.298385571920633 794 1584900
SGTC_2576 guaiol 23.12 µM -0.529464158259573 0.295401377572158 no 2353 0.298241750801056 764 227829
SGTC_2497 7-hydroxyflavone 100 µM -0.529541988843349 0.295374540875022 no 2354 0.298214762346223 769 5281894
SGTC_1832 st054113 55 µM -0.529846440067259 0.295269574085982 no 2355 0.298109201832981 770 1251267
SGTC_2453 5731132 22.18 µM -0.529927245061961 0.295241717528563 no 2356 0.298081187669724 799 1362040
SGTC_900 1112-0045 141 µM -0.530963233116845 0.294884680239507 no 2357 0.297722128838068 768 56211 YIL048W NEO1
SGTC_1254 0550-0035 264 µM -0.531410422270814 0.29473062491343 no 2358 0.29756720038671 760 15121435
SGTC_3347 9188721 44.724 µM -0.5315160990151 0.294694225013296 no 2359 0.297530594110011 780 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1768 st044301 37.178 µM -0.531787024409803 0.294600915398667 no 2360 0.297436755324725 816 3931349
SGTC_1926 methyl fluorone black 53.6 µM -0.537520918499854 0.292629305787981 no 2361 0.295453919706373 757 72721 Reacts with homocysteine.
SGTC_57 miconazole 162.5 nM -0.538114264918081 0.29242563304356 no 2362 0.295249082410987 778 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_952 1185-0122 232 µM -0.538508855116615 0.292290222074815 no 2363 0.295112896690136 776 678600
SGTC_777 1315-0167 517 µM -0.53918037516124 0.292059844550034 no 2364 0.294881200135854 761 4221767
SGTC_1499 4480-0877 67.3 µM -0.539372804232942 0.29199384373806 no 2365 0.294814821220066 764 2861909
SGTC_356 1634-0012 32.5 µM -0.539768663254418 0.291858090789531 no 2366 0.294678290271915 800 735457
SGTC_840 0245-0196 390 µM -0.541243249035395 0.291352666220986 no 2367 0.294169965549241 761 3827528
SGTC_2533 agelasine 13.65 µM -0.541411034835499 0.291295182357305 no 2368 0.294112151483662 774 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1613 st002381 52.1 µM -0.543278560018188 0.290655720883245 no 2369 0.293469011871949 763 551167
SGTC_2350 9023895 38.85 µM -0.543448193566779 0.29059766900812 no 2370 0.29341062564044 761 2997209
SGTC_1086 cerivastatin 2.18 µM -0.544388777285317 0.290275881572675 no 2371 0.293086983486864 761 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3281 9140613 49.47 µM -0.545743444678628 0.289812723565284 no 2372 0.292621151923224 752 16013766
SGTC_294 k038-0071 157 µM -0.54629391142485 0.289624619223753 no 2373 0.292431960408509 775 24152826
SGTC_2642 cholecalciferol 100 µM -0.546424561782062 0.289579982075038 no 2374 0.292387065159131 793 9821465 A vitamin D precursor, similar to steriods.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.546455865727927 0.289569287452798 no 2375 0.292376308691984 759 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1147 3809-1045 12.3 µM -0.547780944752084 0.289116760062622 no 2376 0.291921162113142 763 325925
SGTC_1565 sinapyl alcohol 95.1 µM -0.549039121422622 0.288687388521562 no 2377 0.291489301231342 785 5280507 A phenol propionate derived from cinnamic acid.
SGTC_796 1234-0020 70.7 µM -0.550227830864507 0.288281999809515 no 2378 0.291081558489168 752 46495034
SGTC_142 0335-0849 62.6745 µM -0.551755125594247 0.287761536870079 no 2379 0.290558067983737 768 3889043 YPR107C YTH1
SGTC_1066 ketoconazole 628 nM -0.551889488441951 0.287715770704614 no 2380 0.290512035307554 796 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1404 3909-7820 48.3 µM -0.551899130700281 0.287712486527284 no 2381 0.290508732003652 784 23741373
SGTC_2046 4110841 106 µM -0.552477574700733 0.287515499465647 no 2382 0.29031059728247 788 44119630 YMR134W ERG29
SGTC_1153 4055-0057 267 µM -0.554436922924147 0.286848724631605 no 2383 0.289639931415239 779 882706
SGTC_1103 duloxetine 36.1 µM -0.554474628944178 0.286835900296787 no 2384 0.289627032146443 779 60835 A selective serotonin reuptake inhibitor.
SGTC_815 1582-0027 36.9 µM -0.555516190391051 0.286481758422788 no 2385 0.289270819547539 785 3128206
SGTC_2309 7664088 163.95 µM -0.556100669849557 0.286283120162539 no 2386 0.289071018604114 780 704922
SGTC_2050 5263056 171 µM -0.556849004669015 0.286028890346466 no 2387 0.288815299440328 772 763468 YGL055W OLE1
SGTC_1444 4112-3581 28 µM -0.560421434506184 0.284816719133948 no 2388 0.287596007348627 772 2877249
SGTC_649 1123-0311 367 µM -0.560847294748739 0.284672382972842 no 2389 0.28745082112206 795 693629 YIL048W NEO1
SGTC_368 fentichlor 4.58 µM -0.561584024848015 0.284422766654668 no 2390 0.287199733604812 811 7329 A pesticide.
SGTC_1337 1486-1011 40.3 µM -0.562020767322901 0.284274840484255 no 2391 0.287050934930331 773 X1337
SGTC_1626 st003712 1.76 µM -0.563501948421528 0.283773433426143 no 2392 0.286546566850077 807 24207035
SGTC_2652 actinonin 100 µM -0.565473728081619 0.28310660753547 no 2393 0.28587579444529 782 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2283 7944793 200 µM -0.56560170683198 0.283063353068117 no 2394 0.285832283642436 774 2970533
SGTC_705 1124-0212 310 µM -0.565864991169909 0.282974377772876 no 2395 0.2857427809297 816 9554485
SGTC_2974 9094440 9.66 µM -0.56640185734745 0.282792988821323 no 2396 0.285560316218466 756 25236134
SGTC_3064 1327-0027 10 µM -0.568007754706782 0.282250744000378 no 2397 0.285014851170608 760 16000455 YPR107C YTH1
SGTC_2213 7173844 200 µM -0.568539002134522 0.282071474019532 no 2398 0.284834515126723 787 892728
SGTC_1649 st011737 51.3 µM -0.569010541932869 0.281912398383044 no 2399 0.284674492920206 766 1761035
SGTC_598 3937-0236 20.2 µM -0.571311801730826 0.281136680951233 no 2400 0.283894151589726 803 1379313
SGTC_2405 ticlatone 3.52 µM -0.572931824106965 0.280591216695604 no 2401 0.283345427937325 766 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2060 5238662 140 µM -0.573434316934778 0.280422130628466 no 2402 0.283175330163752 793 790130
SGTC_872 0588-0139 234 µM -0.574487841479839 0.280067785640367 no 2403 0.282818862936264 759 2047100
SGTC_1227 3909-8010 46.6 µM -0.575498861372352 0.279727940966643 no 2404 0.282476980249829 786 15982272
SGTC_1825 st052143 62.6 µM -0.576081147381912 0.279532301941828 no 2405 0.282280166835377 796 674173
SGTC_341 1486-1430 230 µM -0.576567524808274 0.279368937645554 no 2406 0.282115821238275 804 2054753 YPL210C SRP72
SGTC_408 cantharidin 100 µM -0.577148994393105 0.279173694714703 no 2407 0.281919404739677 778 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1511 0906-3109 28.5 µM -0.578049527386457 0.278871449249319 no 2408 0.281615340864801 766 2882180
SGTC_656 4090-1979 187 µM -0.578194250348177 0.278822890803931 no 2409 0.281566490086391 785 22330961
SGTC_1707 st032323 6.317 µM -0.579929830226851 0.278240877867363 no 2410 0.28098096922018 787 3132057 YMR211W DML1
SGTC_633 0437-0093 97.7 µM -0.580427152958319 0.278074213889367 no 2411 0.280813299332283 797 2831118
SGTC_3351 9150312 21.596 µM -0.581361382446139 0.277761264411584 no 2412 0.280498459361672 787 4904905
SGTC_943 3253-1379 105 µM -0.58229268028749 0.277449468258874 no 2413 0.280184777517439 810 668464
SGTC_2928 9011484 9.79 µM -0.582295106344817 0.277448656244516 no 2414 0.28018396058933 789 2994751
SGTC_916 4466-0038 42 nM -0.583599834045624 0.277012125296597 no 2415 0.27974478593357 794 5722064 YGL116W CDC20
SGTC_2082 5219693 150 µM -0.584059141431734 0.276858531986936 no 2416 0.279590261427661 789 2834649
SGTC_763 3453-1109 128 µM -0.584086094041294 0.276849520276021 no 2417 0.279581195064785 796 1560353
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.584308699399608 0.276775096793288 no 2418 0.279506320168122 776 17037758
SGTC_2870 9038528 12.99 µM -0.584534685502685 0.276699553055278 no 2419 0.279430318095241 799 6463316
SGTC_1190 1486-1332 13 µM -0.58578876042749 0.276280518458976 no 2420 0.279008738848614 795 4150046
SGTC_2970 9090938 41.86 µM -0.585836277455576 0.276264647319238 no 2421 0.278992771252179 763 17217104
SGTC_2331 7980721 200 µM -0.586567121976397 0.27602059466298 no 2422 0.278747234662123 784 2981221
SGTC_3208 9114115 49.47 µM -0.58721495017426 0.275804352397366 no 2423 0.278529676452393 806 650895
SGTC_1959 st077091 55.8 µM -0.588791496897746 0.275278455942989 no 2424 0.278000575304399 814 821356 YKL052C ASK1
SGTC_151 3013-0144 2.285 µM -0.590192166060244 0.274811642263037 no 2425 0.277530911805548 793 906558 YHR107C CDC12
SGTC_2389 9091542 195.52 µM -0.590473606215875 0.274717891260422 no 2426 0.277436587883249 785 3626624 YOL127W RPL25
SGTC_904 1141-0088 396 µM -0.591030942264121 0.274532282664374 no 2427 0.277249844440707 815 1378119
SGTC_1038 k292-0204 154 µM -0.591325265617333 0.274434289671439 no 2428 0.277151251990086 795 4454212
SGTC_1126 isoteolin 1.0172 µM -0.592005825610759 0.27420776790006 no 2429 0.276923343685697 783 133323
SGTC_644 1498-1197 63.3 µM -0.592211015345039 0.274139489410313 no 2430 0.276854647040937 790 6741615
SGTC_2842 9000675 19.48 µM -0.593038900513437 0.273864089475836 no 2431 0.27657755943111 789 2989072
SGTC_2434 5670830 169.91 µM -0.595487687333548 0.273050290468638 no 2432 0.275758763504163 816 1549830
SGTC_480 am 92016 50 µM -0.596025841299443 0.272871607943431 no 2433 0.275578981846956 838 2129 K+ channel blocker.
SGTC_1053 3366-3204 134 µM -0.597385629010687 0.272420378044427 no 2434 0.275124973119253 803 3632071 YPR165W RHO1
SGTC_1133 3473-0247 50 µM -0.599095564876927 0.271853482042195 no 2435 0.274554579532096 793 711311
SGTC_1399 3562-5772 25 µM -0.599230750334215 0.271808688979904 no 2436 0.274509509803495 803 23847490
SGTC_3181 9108277 49.47 µM -0.59999337330801 0.27155606628221 no 2437 0.27425532593127 816 17097298
SGTC_2195 6536160 144.242 µM -0.600667533504197 0.27133284473645 no 2438 0.274030723719352 781 3834386
SGTC_529 4076-0302 30.3 µM -0.601043534979624 0.27120838642041 no 2439 0.273905495122254 792 5816522
SGTC_1435 4092-0789 56.7 µM -0.601161836777693 0.271169233837118 no 2440 0.273866100149344 801 2248285
SGTC_325 2810-4341 181 µM -0.601234607009358 0.271145151557927 no 2441 0.273841868762217 788 774970
SGTC_116 0155-0182 31.788 µM -0.601982998012447 0.270897544036891 no 2442 0.273592727401506 774 771486
SGTC_1835 st008666 49.2 µM -0.602201003360041 0.270825437508642 no 2443 0.273520173941493 788 690455
SGTC_225 nsc-122657 1.016 µM -0.604322670761641 0.270124184452749 no 2444 0.272814568304086 808 275685
SGTC_778 3456-2434 196 µM -0.6053289087046 0.269791920729782 no 2445 0.272480238424635 780 5539063
SGTC_2976 9009005 19.48 µM -0.606591536297652 0.269375285849324 no 2446 0.272061009240603 787 2993148
SGTC_1574 spiramycin 23.7 µM -0.607950783107933 0.268927129942019 no 2447 0.27161005841616 809 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2661 dactinomycin 12.96 µM -0.608083928700145 0.268883250780403 no 2448 0.271565905361116 798 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1434 4073-0095 163 µM -0.608677996125416 0.268687515071785 no 2449 0.271368947346293 805 24133745
SGTC_378 3970-0959 8.33 µM -0.610254954245676 0.268168280099493 no 2450 0.270846465761135 813 6615653
SGTC_824 1304-0008 100 µM -0.610289947884281 0.26815676369614 no 2451 0.270834877280855 793 768245
SGTC_834 0312-0008 75.7 µM -0.614315932531241 0.266833476268675 no 2452 0.269503288084927 808 6385573 YIL048W NEO1
SGTC_790 1575-0012 79.1 µM -0.615096761615827 0.266577210724808 no 2453 0.269245410295435 818 378741 YLR208W SEC13
SGTC_2890 9046729 58.44 µM -0.615658066312305 0.266393069285306 no 2454 0.269060109455358 811 903329
SGTC_230 MPP+ 141.667 µM -0.6157942111674 0.266348415347591 no 2455 0.269015174250627 814 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_602 3130-1533 38.1 µM -0.616269256911767 0.266192635509359 no 2456 0.268858412833152 820 720941
SGTC_531 3788-1495 174 µM -0.617543485204948 0.26577501088185 no 2457 0.268438154036651 788 2896655
SGTC_2362 9071156 126 µM -0.61773479714668 0.265712337635946 no 2458 0.268375085141033 811 653133
SGTC_1708 st033234 31.827 µM -0.618167846293589 0.265570499654138 no 2459 0.26823235142499 793 674664
SGTC_2221 6807166 181.081 µM -0.618383986146187 0.265499721041997 no 2460 0.268161125663248 792 674925
SGTC_506 n9-isopropylolomoucine 153 µM -0.618485557059229 0.265466463252219 no 2461 0.268127657725835 806 6610355
SGTC_421 streptovitacin 30 mM -0.618885456586864 0.265335543020833 no 2462 0.26799591000091 809 91467 include heat shock
SGTC_25 0118-0223 35.662 µM -0.622501590323647 0.264153172939768 no 2463 0.2668060491915 813 5333628
SGTC_15 0266-0086 27.098 µM -0.6231831362942 0.263930628281227 no 2464 0.266582091119894 827 1712902 YIL048W NEO1
SGTC_485 niflumic acid 177 µM -0.623919095901014 0.263690423345158 no 2465 0.266340359357636 805 4488 A COX2 inhibitor.
SGTC_1248 0469-0687 58.6 µM -0.624158783814964 0.263612217288624 no 2466 0.266261655916066 807 4017482
SGTC_1472 k841-0093 193 µM -0.62421175218577 0.263594936214142 no 2467 0.266244264916597 822 X1472
SGTC_986 1493-0483 84 µM -0.624562766404103 0.263480431483481 no 2468 0.266129031651097 815 40079
SGTC_2179 6298986 200 µM -0.624704962723354 0.263434052693777 no 2469 0.266082357693003 795 738374
SGTC_1201 1889-3372 45.9 µM -0.626852511582338 0.262734114690314 no 2470 0.265377959197256 798 5392199
SGTC_2208 7283366 200 µM -0.627766503455167 0.262436511542374 no 2471 0.265078456172722 816 898663
SGTC_2835 9006588 71.43 µM -0.631481345523394 0.261228707759183 no 2472 0.2638629213759 779 2345538
SGTC_1997 st073024 93.8 µM -0.632028530031306 0.261051043717661 no 2473 0.263684117352819 806 686268
SGTC_1273 0849-0096 14.1 µM -0.632948808541321 0.260752380821665 no 2474 0.263383536481665 819 5286025
SGTC_443 clozapine 122 µM -0.634865506270792 0.260130909584227 no 2475 0.262758067784096 823 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1048 3161-0300 24.5 µM -0.635368994782758 0.259967784883477 no 2476 0.262593892379732 793 2165101
SGTC_1382 3002-2117 298 µM -0.635761671641294 0.259840598558156 no 2477 0.26246588641692 840 1497314
SGTC_207 4185-0010 4.486 µM -0.635982541880121 0.25976907375867 no 2478 0.262393900523726 811 3761753
SGTC_2288 7946289 167.31 µM -0.637139966363491 0.259394429130218 no 2479 0.262016838813689 815 1246052
SGTC_1793 st048256 72.231 µM -0.63745448135699 0.259292672595031 no 2480 0.261914425231982 811 672022
SGTC_2640 pentamidine 10.38 µM -0.638334935275057 0.259007924878454 no 2481 0.261627837643424 815 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_66 0109-0187 42.4 µM -0.640104536127421 0.258436107595148 no 2482 0.261052320079349 784 759417
SGTC_2124 5246320 200 µM -0.640115407899395 0.258432596583977 no 2483 0.26104878632528 807 579342
SGTC_1417 3966-0327 90.4 µM -0.640382353078294 0.25834639506878 no 2484 0.260962026344415 816 651118
SGTC_2862 9027634 71.43 µM -0.640406265496466 0.258338674035661 no 2485 0.260954255281566 802 5012562
SGTC_490 phenamil 164 µM -0.643061232567357 0.257482161248469 no 2486 0.260092184205028 813 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3169 9102970 49.47 µM -0.644068428815752 0.257157618389596 no 2487 0.259765530908123 818 17027839
SGTC_1998 st075797 76.8 µM -0.64593999585057 0.25655511979412 no 2488 0.259159108061123 815 24208315
SGTC_637 1181-0519 7.26 µM -0.646541786255598 0.25636154656191 no 2489 0.258964272284289 814 6252091 YGR060W ERG25
SGTC_974 1326-0144 138 µM -0.647476252243508 0.256061115099618 no 2490 0.258661879633716 827 5411856
SGTC_144 4161-2749 112.381 µM -0.648449733830685 0.25574833551494 no 2491 0.258347056080204 813 797501 YMR168C CEP3
SGTC_1407 3909-7909 12.3 µM -0.649289135284163 0.255478796105967 no 2492 0.258075753491706 791 4411780
SGTC_2248 tofa 1.1 µM -0.651506605670456 0.254767460873676 no 2493 0.257359757181811 823 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3021 9087658 49.47 µM -0.651866742606652 0.254652031654222 no 2494 0.257243570521259 809 25237042
SGTC_2156 5649887 115 µM -0.652236243735774 0.254533629545542 no 2495 0.257124391149393 818 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2071 5230951 39.92 µM -0.652535429963106 0.254437780120601 no 2496 0.257027912277719 830 1799272
SGTC_1324 1418-0026 34.4 µM -0.653739864589274 0.254052110311165 no 2497 0.256639707652609 818 1372513
SGTC_1770 st043884 66.3 µM -0.653926270039799 0.253992449179402 no 2498 0.256579654096323 833 670149
SGTC_3017 9080681 49.47 µM -0.65416432641348 0.253916267287357 no 2499 0.256502970996009 826 16451914
SGTC_2268 7933382 153.85 µM -0.654258159549424 0.25388624246064 no 2500 0.256472748596754 804 935025 YOR257W CDC31
SGTC_3001 9076041 71.4286 µM -0.654329408688801 0.253863445329906 no 2501 0.256449801440258 808 16004211
SGTC_1922 5578187 25 µM -0.654739681394749 0.253732193910122 no 2502 0.256317686037691 791 1350412
SGTC_1923 st058458 19.1 µM -0.654796437416257 0.253714039748076 no 2503 0.256299412342262 848 3534982
SGTC_456 gingerol 170 µM -0.655031278741469 0.253638929903424 no 2504 0.256223807868442 849 442793 A herb.
SGTC_3248 9135562 49.47 µM -0.65696202472761 0.253021857928414 no 2505 0.25560266736908 813 17650701
SGTC_303 1348-1668 34.2 µM -0.65791203657341 0.252718521610193 no 2506 0.255297327898917 825 5380509
SGTC_1625 st003711 30.1 µM -0.657987681934156 0.252694376476666 no 2507 0.255273023227503 821 24207034 YER133W GLC7
SGTC_756 0508-1999 28.3 µM -0.658042326831223 0.252676935206648 no 2508 0.255255466706831 830 6753853
SGTC_2396 5342950 42.78 µM -0.661832508384113 0.251468753734567 no 2509 0.254039284817472 822 1886677
SGTC_1455 4262-0120 131 µM -0.663325995162126 0.250993520598177 no 2510 0.253560895646327 817 1529587
SGTC_2172 5754775 163.918 µM -0.66503452470959 0.250450443407613 no 2511 0.253014205568912 815 2263357
SGTC_3305 9127027 53.8275 µM -0.666138716589892 0.250099793968937 no 2512 0.252661219821661 825 41905295
SGTC_850 0388-0143 75.9 µM -0.666207213428466 0.250078050554506 no 2513 0.252639331442828 827 67273
SGTC_1903 st060211 78.3 µM -0.666227966801431 0.250071462869018 no 2514 0.252632699834793 807 688960
SGTC_3050 9093513 49.47 µM -0.666286464670735 0.250052894548483 no 2515 0.252614007707041 835 25236664
SGTC_2183 6420625 130.508 µM -0.666774919021323 0.249897878537985 no 2516 0.252457957795997 826 2897619
SGTC_884 0851-0618 334 µM -0.666780636611747 0.249896064303954 no 2517 0.252456131458441 836 9642473
SGTC_945 3381-0768 11.3 µM -0.667201995599361 0.249762383202597 no 2518 0.252321558307102 836 1126236 YIL048W NEO1
SGTC_2096 5468907 200 µM -0.669055911150303 0.249174658023194 no 2519 0.251729906419765 816 759785
SGTC_2519 cryptotanshinone 88.04 µM -0.670523012085255 0.248710082037033 no 2520 0.251262220931994 810 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2959 9079155 11 µM -0.674017025577063 0.247605518717 no 2521 0.250150244755 839 16189457
SGTC_2312 7706453 155.7 µM -0.674796376732385 0.247359500165305 no 2522 0.249902571346998 823 976098
SGTC_3186 9110464 49.47 µM -0.675324571402382 0.247192838744691 no 2523 0.249734788083619 820 17018021
SGTC_2669 eugenol 100 µM -0.677845032879928 0.246398384429573 no 2524 0.248934977350742 801 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2938 9059746 27.26 µM -0.681021850274304 0.245398998050265 no 2525 0.247928832331203 830 6471769
SGTC_1043 0916-0009 19.3 µM -0.681181916609871 0.245348700924195 no 2526 0.247878194451598 840 3101130
SGTC_1144 3486-0183 12.5 µM -0.681270625501299 0.245320828603086 no 2527 0.247850133275814 853 6744069
SGTC_1983 st071813 46.9 µM -0.683504624093497 0.244619468037061 no 2528 0.247144014634968 831 11838595
SGTC_1006 4099-6547 255 µM -0.68584531911891 0.243885770314499 no 2529 0.246405327387571 849 3146833
SGTC_2716 st080858 38.6235 µM -0.68602561392577 0.243829305676955 no 2530 0.246348478249365 820 5296050
SGTC_1174 0739-0097 51.1 µM -0.687165858893729 0.243472367792896 no 2531 0.245989108073418 839 728447
SGTC_1449 4112-4002 201 µM -0.687781424904664 0.243279790776172 no 2532 0.245795217558851 838 2059539
SGTC_2439 5492030 7.2 µM -0.689198168848799 0.242836881872712 no 2533 0.245349284502375 830 5722370
SGTC_3235 9132602 49.47 µM -0.690202879207559 0.242523049420244 no 2534 0.245033306494119 830 4912240
SGTC_1229 0139-0193 12.2 µM -0.690479209736932 0.242436773039355 no 2535 0.244946439876996 838 3090752
SGTC_973 1325-0077 65.9 µM -0.692029149299032 0.24195315664287 no 2536 0.244459511783054 833 2835149
SGTC_3329 9141233 27.5565 µM -0.693339155239219 0.2415448134061 no 2537 0.244048368114116 838 4909101 YNL103W MET4
SGTC_2121 5257820 149.641 µM -0.693438153514819 0.241513969773144 no 2538 0.244017312798615 810 791256
SGTC_1221 2958-7315 257 µM -0.694113298841038 0.241303680380051 no 2539 0.243805579587586 835 4562705
SGTC_3233 9132340 49.47 µM -0.694448684083664 0.241199254005895 no 2540 0.24370043585815 871 17682950
SGTC_2260 7964312 200 µM -0.694606150509766 0.241150233347113 no 2541 0.243651078366171 829 231951
SGTC_2375 9072683 200 µM -0.694803549233189 0.241088789070149 no 2542 0.243589211812097 844 16798029
SGTC_2587 piperic acid 92.2 µM -0.696190340433412 0.240657362792481 no 2543 0.243154818099958 818 5370536
SGTC_1726 st035556 14.5795 µM -0.696736905386451 0.240487443716883 no 2544 0.242983729110951 818 5919439
SGTC_139 0099-0334 718.624 µM -0.697146171347207 0.240360251685983 no 2545 0.242855660912201 854 97690
SGTC_2532 xanthone 78.9 µM -0.698578278467891 0.239915468803456 no 2546 0.242407811192005 818 7020 An insecticide.
SGTC_1877 wortmannin 25 µM -0.699739805944657 0.239555052315426 no 2547 0.242044906238785 838 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2741 miltefosine 3.04 µM -0.69979161741197 0.239538982351384 no 2548 0.242028725251274 812 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_746 1095-0025 46.6 µM -0.699822229141921 0.239529488023307 no 2549 0.242019165326396 841 6749286
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.700017877458464 0.239468811911661 no 2550 0.241958069951278 862 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3344 9148862 3.898 µM -0.701246869207974 0.23908785860461 no 2551 0.241574482369424 853 4905352
SGTC_468 gf-109203x 121 µM -0.70223459962388 0.238781929866592 no 2552 0.241266435723561 813 2396 A protein kinase C inhibitor.
SGTC_577 r071-0003 38.6 µM -0.702302690879293 0.238760847924187 no 2553 0.241245207753841 867 4568517 YMR134W ERG29
SGTC_1882 5615643 20 µM -0.702314843189652 0.238757085517195 no 2554 0.24124141928488 821 2253075
SGTC_1408 3909-7976 48.8 µM -0.702978276215346 0.238551733058286 no 2555 0.241034643866005 842 24152374
SGTC_2351 9026858 72.31 µM -0.703245077329563 0.238469177361113 no 2556 0.240951515836744 862 1409300
SGTC_1438 4092-1045 4 µM -0.70353151280045 0.238380563660866 no 2557 0.240862287631086 846 1351342
SGTC_1495 4469-0029 237 µM -0.703660921769238 0.238340534702859 no 2558 0.240821981026615 825 793680
SGTC_1638 st008370 60.6 µM -0.704023132434189 0.238228514782621 no 2559 0.240709183923806 821 24207134
SGTC_3297 9117502 71.43 µM -0.704038108917909 0.238223883666737 no 2560 0.240704520671482 819 7453720
SGTC_1129 3453-1384 223 µM -0.70642382701335 0.237486788031307 no 2561 0.239962303833656 856 1084452
SGTC_2200 6600604 21.907 µM -0.707071652645785 0.237286851033535 no 2562 0.239760975545815 863 2904777
SGTC_3269 9137823 49.47 µM -0.70827180210456 0.236916695940731 no 2563 0.239388242235946 804 17682936
SGTC_329 k048-0121 21.3 µM -0.708368651579144 0.236886839070391 no 2564 0.239358177267364 841 6832902
SGTC_846 0335-0850 148 µM -0.709366087925318 0.236579468605209 no 2565 0.23904866327348 831 6819598
SGTC_2774 tamoxifen 10.92 µM -0.70960879077128 0.236504710387544 no 2566 0.238973383379179 845 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1402 3909-7673 35.9 µM -0.710470381190159 0.236239425182651 no 2567 0.238706245921081 836 5328014
SGTC_2682 pyrogallin 40.03 µM -0.711140588354912 0.236033180586258 no 2568 0.238498560174258 828 822798 An ATP competetive kinase inhibitor.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.711940634278938 0.235787110331581 no 2569 0.238250769195325 833 641818 YHR062C RPP1
SGTC_2794 7785382 27.27 µM -0.711952045900977 0.235783601480582 no 2570 0.23824723579743 832 2205081
SGTC_3011 9081274 71.4286 µM -0.714061713118398 0.235135414880448 no 2571 0.237594509778958 845 6625322
SGTC_546 peri-Naphthalide 147 µM -0.714068381033775 0.235133367752189 no 2572 0.237592448298703 817 223824 A penicillin ester.
SGTC_2341 7987486 176.74 µM -0.715180655570486 0.234792024224188 no 2573 0.237248710322392 820 1258686
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.719090547669277 0.233594302508787 no 2574 0.236042565471951 840 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2950 9072895 21.46 µM -0.720240899630325 0.233242559996303 no 2575 0.235688342956305 819 17332245
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.720972731958429 0.233018941094326 no 2576 0.23546314590729 853 94937 An inhibitor of serotonin biosynthesis.
SGTC_360 0957-0399 1.01 µM -0.721693406180948 0.232798848066365 no 2577 0.235241498480418 842 6752301 YPR165W RHO1
SGTC_3042 9091578 49.47 µM -0.722033216639229 0.232695110454133 no 2578 0.235137027834584 830 25236497
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.722874707419442 0.232438330090184 no 2579 0.234878431925623 852 803109
SGTC_1238 0333-0287 48.8 µM -0.722954389246374 0.232414023403173 no 2580 0.234853953300668 835 7226
SGTC_501 nsc-95397 161 µM -0.723089309396689 0.23237286966566 no 2581 0.23481250842308 846 262093
SGTC_3265 9137266 49.47 µM -0.723414230133136 0.232273778033006 no 2582 0.234712715609931 797 17224265
SGTC_780 0109-0199 192 µM -0.723512442931308 0.232243830536047 no 2583 0.234682556157079 836 610414
SGTC_149 3970-0822 46.1 µM -0.724116560034624 0.232059667639343 no 2584 0.234497089373439 839 3114250 YBL034C STU1
SGTC_907 3448-6986 75.5 µM -0.724191618995565 0.232036791868137 no 2585 0.234474051584971 851 590582
SGTC_219 mitoxanthrone 164.414 µM -0.724260625529744 0.232015761806943 no 2586 0.23445287256798 864 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1135 dihydrocapsaicin 536.708 nM -0.726655659018573 0.231286522177012 no 2587 0.233718461369227 870 107982 A Capsaicinoid.
SGTC_37 0566-0070 1.56 µM -0.726860599302713 0.231224181410847 no 2588 0.233655677924694 853 1626686
SGTC_2939 9044578 71.43 µM -0.726981705434245 0.231187346554969 no 2589 0.233618581463967 856 2653634
SGTC_1383 3049-0032 20.7 µM -0.727095018383954 0.231152884987735 no 2590 0.233583875118595 860 712864
SGTC_3292 9120825 59.784 µM -0.728409713768397 0.230753259789073 no 2591 0.233181409388457 842 24824900
SGTC_3193 9111931 49.47 µM -0.728458116881097 0.230738554165667 no 2592 0.233166599166637 884 17087244
SGTC_155 k072-0202 43.6 µM -0.728722484863859 0.230658244272296 no 2593 0.233085717954709 848 5857737
SGTC_184 1494-0393 24.714 µM -0.729283473828232 0.230487878388705 no 2594 0.232914139603149 850 3090647
SGTC_1806 st050005 60.3 µM -0.730139283471064 0.230228114407512 no 2595 0.232652525618575 834 5194765
SGTC_727 3032-0951 202 µM -0.730634523071867 0.230077869111487 no 2596 0.232501209577734 849 3652836
SGTC_2714 st079313 56.9 µM -0.731912619599939 0.229690375066703 no 2597 0.232110951569595 847 2939799
SGTC_722 3534-0461 190 µM -0.73251305189532 0.2295084619246 no 2598 0.231927739647053 841 658262
SGTC_1893 st059353 36.1 µM -0.733045441653772 0.22934723119796 no 2599 0.23176535715752 881 3112488
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.736689758660429 0.228245280290474 no 2600 0.230655518127137 832 688669
SGTC_1200 1643-0193 18.4 µM -0.738267516166111 0.227769130388891 no 2601 0.230175951005625 861 5403974
SGTC_232 clozapine 119 µM -0.74174760084644 0.226720858052097 no 2602 0.229120136753605 848 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_861 0443-0273 110 µM -0.742812822547179 0.226400536627596 no 2603 0.228797505605161 860 6149169
SGTC_2903 5923464 63.88 µM -0.744108098631018 0.22601138042123 no 2604 0.228405540095303 851 2876576
SGTC_1736 st036774 51 µM -0.74640314150975 0.225322781058207 no 2605 0.227711961055581 863 1272247
SGTC_2685 mycophenolic acid 18.85 µM -0.747445940990646 0.225010294875918 no 2606 0.227397211426061 833 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2462 5162487 171.77 µM -0.747970546728462 0.224853183973825 no 2607 0.227238961648144 844 2259986
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.749739555994562 0.224323853117967 no 2608 0.226705789475427 853 1273210
SGTC_3202 9113761 49.47 µM -0.752165272846234 0.223599170635063 no 2609 0.225975837339955 857 4798415
SGTC_2730 imipramine 71.33 µM -0.752252079006596 0.223573262008449 no 2610 0.2259497400856 845 3696 A tricyclic antidepressant.
SGTC_1752 st044819 83.042 µM -0.753329829387604 0.223251733144341 no 2611 0.225625869016211 848 441209 YML126C ERG13
SGTC_1769 st044406 64.4 µM -0.754059636011024 0.223034157039077 no 2612 0.225406706578017 874 670903
SGTC_1673 st016611 27.3 µM -0.75538729955929 0.222638652614627 no 2613 0.225008315701755 865 5226799
SGTC_694 1315-0438 43.2 µM -0.756063163711005 0.222437469680505 no 2614 0.224805663089672 836 6793154
SGTC_2911 7942208 15.64 µM -0.756741819934787 0.222235560004057 no 2615 0.224602277467168 824 1243384
SGTC_1567 st069303 68.4 µM -0.75680269472588 0.222217454018578 no 2616 0.224584039081209 856 5581319
SGTC_1031 k035-0009 16 µM -0.759830607569752 0.221317924920467 no 2617 0.223677922419443 864 5180959
SGTC_3162 9099653 49.47 µM -0.760723646552056 0.221053020063785 no 2618 0.223411073932973 817 25237511
SGTC_1693 xanthone 101.9 µM -0.761418081033369 0.220847153331592 no 2619 0.22320369559455 874 7020 An insecticide.
SGTC_150 3970-0969 77.2 µM -0.761675262562688 0.220770939127649 no 2620 0.22312692152291 883 6615640
SGTC_123 0083-0120 66.675 µM -0.762811132148638 0.220434511206204 no 2621 0.222788020570162 875 16001701
SGTC_2255 7941087 197.44 µM -0.762908572070544 0.220405664620391 no 2622 0.222758961812915 850 935561
SGTC_340 k038-0059 454 µM -0.763432621912306 0.220250559486124 no 2623 0.222602715517401 863 23733424
SGTC_11 0438-0307 1.3 µM -0.763476635267618 0.220237535526362 no 2624 0.222589595710055 872 4011476
SGTC_2063 5246145 200 µM -0.764552989343092 0.219919169860699 no 2625 0.222268885839941 864 711240
SGTC_1787 fluconazole 80 µM -0.764637694615173 0.219894126819501 no 2626 0.222243658299004 831 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2678 equilin 100 µM -0.768267054087877 0.218822648159731 no 2627 0.221164271827041 826 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3289 9119912 71.43 µM -0.771718879321666 0.217806375071625 no 2628 0.220140473229986 868 17014829
SGTC_2114 5491910 81.25 µM -0.773448356085032 0.217298214635091 no 2629 0.219628540675825 857 2849228
SGTC_1041 0206-0046 107 µM -0.773658539937007 0.217236504434104 no 2630 0.219566371977489 885 50494
SGTC_1644 st010134 20.9 µM -0.773707072329658 0.217222256710988 no 2631 0.219552018383124 866 3818134
SGTC_956 1185-0240 191 µM -0.774072551985937 0.217114979670389 no 2632 0.21944394403903 866 1416193
SGTC_394 menadione 8.33 µM -0.775208358420681 0.216781788696665 no 2633 0.219108274983536 868 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_424 splitomicin 100 mM -0.775388868862371 0.216728862857729 no 2634 0.219054955270099 875 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1872 amphotericin b 148 nM -0.775776781508071 0.216615151775887 no 2635 0.2189403977244 854 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3097 9117246 49.47 µM -0.776765823922698 0.216325384262545 no 2636 0.218648471796076 851 16423892
SGTC_2807 7945238 51.95 µM -0.778011939196271 0.215960619735157 no 2637 0.218280987379241 870 17148797
SGTC_2421 5690543 90.72 µM -0.781555158805333 0.214925393025274 no 2638 0.217238024194405 858 3397993
SGTC_386 1509-0011 3.07 µM -0.782659215037374 0.214603409522943 no 2639 0.216913629235777 857 3107280
SGTC_979 1426-2828 121 µM -0.786285350265359 0.213547869497158 no 2640 0.215850166537469 869 747872
SGTC_628 1636-0253 16 µM -0.786542246585217 0.213473203891067 no 2641 0.21577493949953 870 4456143
SGTC_1191 1487-1166 10.6 µM -0.78963592022625 0.212575238995625 no 2642 0.214870212121725 892 3955771
SGTC_1624 st003710 6.25 µM -0.792172077156731 0.211840746377342 no 2643 0.214130173783247 877 24207033
SGTC_716 1683-5115 658 µM -0.792253482509191 0.211817195315684 no 2644 0.214106444687868 872 723597
SGTC_2191 5911152 200 µM -0.792610454214143 0.211713939328297 no 2645 0.214002407982472 853 2875902
SGTC_1462 k081-0014 26.5 µM -0.793439242969124 0.211474321342999 no 2646 0.213760977263369 827 3270634
SGTC_914 3820-6779 408 µM -0.79349701364112 0.211457624708023 no 2647 0.21374415426546 864 2893481
SGTC_1196 1588-0294 184 µM -0.794356715670013 0.211209248503544 no 2648 0.213493897519835 875 6144269
SGTC_3308 9128332 17.569 µM -0.794422980540644 0.21119011104202 no 2649 0.213474615100733 839 17332805 YDL196W YDL196W
SGTC_3190 9110366 49.47 µM -0.794616600573814 0.211134198911032 no 2650 0.213418279410489 856 17123768
SGTC_2340 7987427 183.45 µM -0.79463861526988 0.21112784222265 no 2651 0.213411874562625 850 2239331
SGTC_1845 st056753 3.01 µM -0.796748653113792 0.210519094806451 no 2652 0.212798510672958 853 5375839
SGTC_440 fluspirilene 35.1 µM -0.797152145113017 0.210402804515041 no 2653 0.212681337476237 891 3396 An atypical antipsychotic.
SGTC_2745 rifampicin 24.3 µM -0.797224393292176 0.210381985873476 no 2654 0.212660360740047 832 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_73 0327-0325 16.231 µM -0.798775775205373 0.20993523998201 no 2655 0.212210219800484 831 53298
SGTC_2262 9014885 67.46 µM -0.799648154649902 0.209684269091055 no 2656 0.211957339553405 865 6457424
SGTC_91 0417-1751 58.384 µM -0.80228387989701 0.208927081795359 no 2657 0.211194382501055 879 6795624
SGTC_1988 st071872 53.4 µM -0.803380098224748 0.208612636657683 no 2658 0.210877537246258 858 16414116
SGTC_2182 6325192 200 µM -0.804232319640687 0.208368373766856 no 2659 0.210631408288709 846 736248
SGTC_3328 9140624 29.0385 µM -0.80476585154359 0.20821553926466 no 2660 0.21047740546447 868 4904392
SGTC_1987 st072290 61.9 µM -0.805104881519931 0.208118455782695 no 2661 0.210379579549399 865 54697379
SGTC_2752 diclazuril 33.15 µM -0.807196705883096 0.207520039203182 no 2662 0.209776581647606 869 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2021 4019055 173 µM -0.808939556599342 0.207022232390566 no 2663 0.209274957181243 886 44827708 YER133W GLC7
SGTC_18 0111-0177 500 nM -0.809454322653769 0.206875336111682 no 2664 0.209126933221083 881 721752
SGTC_2403 6032726 181.2 µM -0.809974219353248 0.206727038363454 no 2665 0.208977496504976 887 2881040
SGTC_2103 5378138 10 µM -0.810158948614497 0.206674360490913 no 2666 0.208924413924054 862 244142
SGTC_2324 6149169 200 µM -0.815460618202914 0.205165913042536 no 2667 0.207404349094447 873 2888231
SGTC_1415 3966-0071 78.1 µM -0.815779184124445 0.205075482527377 no 2668 0.207313220377196 870 2893185
SGTC_933 2914-0560 114 µM -0.817089845147999 0.204703677756003 no 2669 0.206938542871318 867 463887
SGTC_867 0518-0118 155 µM -0.818146991455614 0.204404081701951 no 2670 0.206636629566363 875 6848158
SGTC_152 4469-0003 551.229 µM -0.818995123107109 0.204163909366114 no 2671 0.206394598027839 861 697280
SGTC_3055 9094636 49.47 µM -0.819873888521448 0.203915239594028 no 2672 0.206144001801024 882 25236176
SGTC_3252 9135871 49.47 µM -0.820963702265776 0.203607098999906 no 2673 0.205833471950235 888 17682838
SGTC_3314 9135860 59.4275 µM -0.821243563785509 0.203528014077124 no 2674 0.205753773448557 865 25252478
SGTC_1969 st069479 40.1 µM -0.82487056259873 0.202504733672832 no 2675 0.204722540258029 880 3895485
SGTC_606 k015-0008 38.6 µM -0.825125782681518 0.202432844784068 no 2676 0.204650091703579 900 1970475
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.825146685334145 0.202426957724214 no 2677 0.204644158806528 878 688788
SGTC_2788 5282734 71.43 µM -0.827967473207741 0.201633445461176 no 2678 0.203844460474308 884 743706
SGTC_911 3456-4043 236 µM -0.828179271405675 0.201573940078857 no 2679 0.203784490582322 873 914281
SGTC_2447 5741742 33.78 µM -0.828343500687996 0.201527806578475 no 2680 0.203737996896295 883 1776504
SGTC_725 1497-0963 19 µM -0.829786536402976 0.201122716784992 no 2681 0.203329742154729 868 3549977
SGTC_98 0074-0023 107.663 µM -0.830416332170458 0.200946073345081 no 2682 0.203151717356891 868 3563821
SGTC_154 3389-1638 511.116 µM -0.830562326271872 0.200905138601565 no 2683 0.203110462393789 911 5238686
SGTC_2736 butenafine 14.65 µM -0.832822989742366 0.200271918364274 no 2684 0.202472283473946 872 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_194 1486-1323 56.904 µM -0.834619872756866 0.199769461212464 no 2685 0.201965884675783 881 5178754
SGTC_2827 7993847 71.43 µM -0.834654900270034 0.19975967411243 no 2686 0.201956020737328 843 2985692
SGTC_1691 st019933 84.6 µM -0.83483911888039 0.199708206009208 no 2687 0.20190414852009 908 6176082
SGTC_3189 9110682 49.47 µM -0.835274807297843 0.199586512510454 no 2688 0.201781499258821 891 17122418
SGTC_452 diindolylmethane 8 µM -0.83551085526991 0.199520599853277 no 2689 0.201715068782584 874 3071 Inhibits expression of several cancer promoting factors.
SGTC_1786 berberine 21.6 µM -0.837346312426598 0.199008524671019 no 2690 0.20119896705225 873 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2999 9069765 71.4286 µM -0.838054470695577 0.198811167120967 no 2691 0.201000055930612 863 2097066
SGTC_404 fumagillin 50 µM -0.839038352294008 0.198537163802299 no 2692 0.200723894116835 880 12015870 A methionine aminopeptidase binder.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.841397863362561 0.197880987292989 no 2693 0.20006254103099 892 4213774
SGTC_3152 9099253 49.47 µM -0.843087274596122 0.197411970386636 no 2694 0.199589817590802 865 25236131
SGTC_370 0180-0345 38.7 µM -0.843133055325456 0.197399270033811 no 2695 0.199577016795048 868 3989527
SGTC_2879 9041815 71.43 µM -0.845706419063804 0.196686169920204 no 2696 0.198858270662685 859 4942971
SGTC_2647 atorvastatin 60.16 µM -0.849516904274855 0.195633123645839 no 2697 0.197796864003909 875 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.849543561375554 0.195625768902865 no 2698 0.197789450774097 887 16725076
SGTC_125 0133-0007 11.75 µM -0.851451257631575 0.195099867980298 no 2699 0.197259364302372 872 26541
SGTC_540 1187-0821 17.3 µM -0.851538522043557 0.19507583208384 no 2700 0.197235136946062 892 847520
SGTC_920 mycophenolic acid 780.421 nM -0.855135937423159 0.194086536036897 no 2701 0.196237948243042 895 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.855297606674954 0.19404214856929 no 2702 0.196193206084756 847 6708630 An antioxidant.
SGTC_967 1306-0166 352 µM -0.856083730774672 0.19382640065573 no 2703 0.195975733484387 887 4437607
SGTC_1441 4106-0040 13 µM -0.856957643027979 0.193586731414763 no 2704 0.195734146983977 878 2904180
SGTC_734 2023-0417 80 µM -0.857184653331655 0.193524503734293 no 2705 0.195671421274895 891 3935732
SGTC_166 k072-0058 166.424 µM -0.86254621117188 0.192058351772057 no 2706 0.194193507549162 885 5846229
SGTC_664 1222-0054 14.9 µM -0.863037422529408 0.191924367651198 no 2707 0.194058445931264 879 6813991
SGTC_352 k048-0007 5.11 µM -0.863598649055977 0.191771356052206 no 2708 0.193904203273404 918 6811911
SGTC_1524 corynanthine 62.1 µM -0.863754852358283 0.191728782409515 no 2709 0.193861287000303 925 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1841 st054148 70 µM -0.865117805048295 0.191357551499275 no 2710 0.193487066541816 905 675442
SGTC_1242 0402-0103 60.1 µM -0.866517048445543 0.190976894607472 no 2711 0.193103340648916 888 432868
SGTC_1256 0570-0116 285 µM -0.866894892141318 0.190874183891217 no 2712 0.192999801224469 901 410638
SGTC_836 0330-0104 1.35 µM -0.870873025307764 0.189794850355874 no 2713 0.19191174340061 864 46494820
SGTC_634 1611-4317 11.2 µM -0.871375489051704 0.189658791071167 no 2714 0.191774582291405 908 2843522
SGTC_1345 1488-0192 31.4 µM -0.872791441367022 0.189275696318856 no 2715 0.191388382720197 888 658348
SGTC_1047 2043-3044 82 µM -0.873471756365722 0.189091802394364 no 2716 0.191202997118005 932 669592
SGTC_2891 9063876 19.48 µM -0.873526057705514 0.189077129104141 no 2717 0.191188204767388 873 6472478
SGTC_3218 9131285 49.47 µM -0.875523035603293 0.188537993610249 no 2718 0.190644690964789 895 17156417
SGTC_3260 9137109 49.47 µM -0.875720370680484 0.188484769448039 no 2719 0.190591034177789 863 17478346
SGTC_731 3966-0296 387 µM -0.876272999815762 0.188335766586815 no 2720 0.19044081979345 878 660956
SGTC_542 3381-0244 89.3 µM -0.878363881145698 0.187772669672381 no 2721 0.189873139414697 923 1112843
SGTC_1604 st002052 72.4 µM -0.879696685632043 0.187414274296764 no 2722 0.189511822675363 885 6254834 YHR062C RPP1
SGTC_2898 9056270 58.44 µM -0.880593791580956 0.187173277895458 no 2723 0.189268860054346 840 19154699
SGTC_1506 4226-2149 212 µM -0.880715596718631 0.18714057123761 no 2724 0.189235886440635 910 991114
SGTC_751 0833-0568 350 µM -0.881107793491398 0.187035284049812 no 2725 0.189129739704154 892 6954252
SGTC_2246 7293507 91.5585 µM -0.881573979564411 0.186910181740122 no 2726 0.189003615718233 884 887656
SGTC_3334 9142812 21.919 µM -0.883359839889441 0.186431420496238 no 2727 0.188520940951075 889 45283678
SGTC_932 2857-0803 154 µM -0.884003135597858 0.186259149228466 no 2728 0.188347260089838 908 674898
SGTC_765 1319-0117 244 µM -0.884371883323106 0.186160444983346 no 2729 0.188247747872053 878 3487746 YGL099W LSG1
SGTC_2858 9025781 8.96 µM -0.884496111224664 0.186127199683339 no 2730 0.188214230377989 872 4894980 YPL153C RAD53
SGTC_3069 9117009 49.47 µM -0.885022140649794 0.185986466892328 no 2731 0.188072345038745 871 41904981
SGTC_2919 7978188 46.38 µM -0.885145776392976 0.185953399227134 no 2732 0.188039006490001 866 2980291
SGTC_2473 5854593 8.94 µM -0.88616514286198 0.185680898019008 no 2733 0.187764271965661 894 2872951
SGTC_599 1935-0052 86.5 µM -0.889259394645628 0.184855248482711 no 2734 0.186931844364878 901 9557311
SGTC_680 0417-1641 114 µM -0.890631410095067 0.184489880344763 no 2735 0.186563471328839 899 2835990
SGTC_807 1315-0151 48 µM -0.892984664968377 0.183864254606711 no 2736 0.185932692474234 919 4011080
SGTC_1766 st045414 44.774 µM -0.893318168860734 0.183775697787059 no 2737 0.185843405440748 892 253960
SGTC_2029 5175081 200 µM -0.894863535568612 0.183365696368857 no 2738 0.185430020700662 898 1380876
SGTC_769 0302-0231 76 µM -0.894947189154343 0.183343518509803 no 2739 0.185407659709935 908 571869 YER009W NTF2
SGTC_683 panaxydol 45 µM -0.895283765955764 0.183254303698458 no 2740 0.18531770809033 880 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1051 3253-3903 78 µM -0.896278807622982 0.182990711101226 no 2741 0.185051937361706 889 5509239
SGTC_597 k018-0003 82.8 µM -0.896421759657816 0.182952861681593 no 2742 0.185013775039302 920 6786234
SGTC_931 2812-0076 566 µM -0.896487752706003 0.182935390346221 no 2743 0.184996159255487 909 3450959
SGTC_1958 st076513 41.9 µM -0.898565882810056 0.18238574833008 no 2744 0.18444196901763 912 732122 YGL099W LSG1
SGTC_2149 5554786 194.827 µM -0.899942796805108 0.182022138984985 no 2745 0.184075346664974 919 745063 YPR165W RHO1
SGTC_2933 9026794 32.47 µM -0.900902142375732 0.181769067360973 no 2746 0.183820176023808 900 17586027
SGTC_2695 st077686 51.995 µM -0.901042257768278 0.18173212389689 no 2747 0.183782926009476 917 2876092
SGTC_829 1635-0120 117 µM -0.901509287547752 0.181609018620744 no 2748 0.183658798979174 888 285054
SGTC_2237 6667747 47.222 µM -0.90418591217277 0.180904488997496 no 2749 0.182948414510425 932 729940 YDL015C TSC13
SGTC_2249 haloperidol 116.36 µM -0.905022144883915 0.180684731063019 no 2750 0.182726827757415 891 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_547 1120-0019 610 nM -0.905261695262071 0.180621809231618 no 2751 0.182663382067655 861 3676939
SGTC_3118 9124250 49.47 µM -0.905697596619105 0.180507347855177 no 2752 0.182547967481431 883 1504786
SGTC_1590 st077108 57.8 µM -0.906042544754466 0.180416801731533 no 2753 0.182456667074299 885 5489485
SGTC_287 k060-0039 29.6 µM -0.908296535979559 0.179825848714237 no 2754 0.181860786097725 897 5861974
SGTC_2860 9025725 38.96 µM -0.909769978883496 0.179440198383549 no 2755 0.181471915057566 917 40546248
SGTC_3345 9148410 3.559 µM -0.910856075260983 0.179156263000777 no 2756 0.181185606014757 881 4903596
SGTC_702 1488-0190 94 µM -0.910936719530326 0.179135191654029 no 2757 0.181164358432994 879 949357
SGTC_88 0180-0332 8.668 µM -0.911404746885987 0.179012932695007 no 2758 0.181041076710984 903 3101745
SGTC_3033 9090887 49.47 µM -0.911408474645268 0.179011959133732 no 2759 0.181040095003816 913 19325384
SGTC_1012 4112-3522 18 µM -0.912682131823281 0.178679519147629 no 2760 0.180704872049163 890 3112398
SGTC_937 3122-0005 46.7 µM -0.912779510583776 0.178654118115398 no 2761 0.180679258260839 879 759535
SGTC_1307 1187-1599 12.2 µM -0.91329284086218 0.178520254647378 no 2762 0.180544273297247 905 1538471
SGTC_3167 9103034 49.47 µM -0.913304134449192 0.178517310277834 no 2763 0.180541304254936 903 5127859
SGTC_1116 jasmonic acid 1.58368 µM -0.914034705382801 0.178326906926643 no 2764 0.180349304923873 896 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_327 1273-0057 3.96 µM -0.916404017343887 0.177710291377693 no 2765 0.179727514517125 885 3108138
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.916640743658168 0.177648757146696 no 2766 0.17966546333819 932 5393153
SGTC_1381 2324-0066 62.1 µM -0.916658021889685 0.177644266399443 no 2767 0.179660934860479 894 10885928
SGTC_563 tetrahydrosecaminediol 614 µM -0.91900970348554 0.177033714459451 no 2768 0.179045248391717 912 334274 A psychoactive constituent of the cannabis plant.
SGTC_2034 5197015 53.07 µM -0.919282059389646 0.176963090215623 no 2769 0.178974029609942 911 780676
SGTC_2915 7971052 15.16 µM -0.919463707916854 0.176915997078103 no 2770 0.178926539956371 865 5741558
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.919490421678298 0.176909072092225 no 2771 0.178919556658546 923 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1803 st050068 52.4 µM -0.91967671589887 0.176860783961318 no 2772 0.178870861882731 923 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1309 pyrazolanthrone 13.4 µM -0.920076315711323 0.176757234357288 no 2773 0.178766440064443 919 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_487 nimodipine 119 µM -0.920427874147845 0.176666165570854 no 2774 0.178674603965654 898 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3114 9122766 49.47 µM -0.920698638744717 0.176596046098623 no 2775 0.17860389354823 874 17176985
SGTC_319 1348-1596 45.5 µM -0.921850248613153 0.176298012193931 no 2776 0.178303346506621 902 5380505
SGTC_728 3030-5151 22.5 µM -0.921956321611288 0.17627057677056 no 2777 0.178275679623247 907 3125388
SGTC_3168 9103419 49.47 µM -0.924024390283662 0.175736217703943 no 2778 0.177736808583439 898 16649256
SGTC_862 0452-0056 10.2 µM -0.92484028162 0.17552568576424 no 2779 0.177524496969883 916 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1350 1495-0454 146 µM -0.924854082777167 0.175522125900235 no 2780 0.177520907003806 893 1069057
SGTC_2531 methyl deoxycholate 70.07 µM -0.925650136014772 0.175316869744711 no 2781 0.177313914662296 938 16667744 Haematoxylin.
SGTC_1612 st002233 45.4 µM -0.926316877910152 0.175145072683022 no 2782 0.177140663604415 890 1035021
SGTC_432 NS 1619 61.3 µM -0.926960575696612 0.174979314662041 no 2783 0.176973501982613 898 4552 A K+/calcium channel activator.
SGTC_2196 6573537 42.6665 µM -0.927138121271548 0.174933612584707 no 2784 0.176927412786932 929 2903087
SGTC_1954 st077032 68.9 µM -0.928197941325463 0.174660961461536 no 2785 0.176652451067927 924 698907
SGTC_2070 5230947 200 µM -0.9292642926251 0.17438690256598 no 2786 0.176376067727605 923 2835538
SGTC_2380 9035439 200 µM -0.929593831284561 0.1743022643739 no 2787 0.176290711283348 918 6462575
SGTC_2748 diazoxide 86.69 µM -0.930570491622541 0.174051573807097 no 2788 0.176037892241969 844 3019 A potassium channel activatior.
SGTC_1096 rimcazole 32.2 µM -0.934164651006445 0.173130994952284 no 2789 0.175109483429917 899 18528119 A dopamine reuptake inhibitor.
SGTC_1967 st070177 51.4 µM -0.935691582994316 0.172740839314414 no 2790 0.174716002766327 936 5729214
SGTC_26 0302-0163 425.158 µM -0.938429051640402 0.17204277638513 no 2791 0.174011980960294 945 3100915
SGTC_2830 7992007 71.43 µM -0.941743742269506 0.171199933962785 no 2792 0.173161927050787 909 1952075
SGTC_605 1315-0399 119 µM -0.945249496694597 0.170311386924844 no 2793 0.172265757618245 915 24020461
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.945374677923817 0.170279713980658 no 2794 0.17223381259133 895 688667
SGTC_2605 digitonin 300 nM -0.947793901266249 0.16966835126585 no 2795 0.171617192951016 907 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_282 k297-0036 65.7 µM -0.947857431110882 0.169652315613492 no 2796 0.171601019282659 935 5061378
SGTC_277 nystatin 15.5 µM -0.951870013127076 0.16864146456619 no 2797 0.170581454569576 942 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1891 st059073 26.2 µM -0.952661040372008 0.168442646470341 no 2798 0.17038091951676 910 688754
SGTC_687 k029-0044 34.9 µM -0.953845378438118 0.168145254869097 no 2799 0.170080957779415 910 5829338
SGTC_2358 9037157 4 µM -0.953870200305751 0.168139025624282 no 2800 0.170074674675266 913 2388925
SGTC_3270 9137563 49.47 µM -0.955698538921172 0.167680597827717 no 2801 0.169612280448778 879 17015724
SGTC_1616 st002734 56.1 µM -0.956025102728971 0.167598801780375 no 2802 0.169529776107338 915 4026101
SGTC_2296 7971656 126.45 µM -0.956678002880619 0.167435343732102 no 2803 0.169364902110034 909 666570
SGTC_1093 fluphenazine 7.97 µM -0.957287217830808 0.167282915247092 no 2804 0.169211152592507 936 6602611 An atypical antipsychotic.
SGTC_2881 9058953 51.95 µM -0.959469384622003 0.166737660926978 no 2805 0.168661167832064 890 17122249
SGTC_1296 1068-0102 11.9 µM -0.95952656480813 0.166723388845888 no 2806 0.168646771827215 910 767053
SGTC_2775 cyproheptadine 69.59 µM -0.961456011628924 0.166242264167773 no 2807 0.168161466459543 910 2913 A selective serotonin reuptake inhibitor.
SGTC_1206 3978-0017 132 µM -0.961466556203962 0.166239637250685 no 2808 0.168158816699516 917 3873677
SGTC_3039 9090270 49.47 µM -0.961518502721211 0.166226696466781 no 2809 0.168145763383537 877 17173750
SGTC_537 1334-0398 209 µM -0.964297135074861 0.165535438977414 no 2810 0.167448488414894 907 5846986
SGTC_739 1486-1183 203 µM -0.964414712064151 0.16550622968596 no 2811 0.167419024578095 916 4346692
SGTC_2035 5154463 94.595 µM -0.965329990185689 0.165278963942481 no 2812 0.167189777557564 918 2769623
SGTC_2664 lyso-paf C-16 73.48 µM -0.965340436904022 0.165276371163574 no 2813 0.167187162167309 920 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_503 tyrphostin 8 294 µM -0.965751433896552 0.165174386398031 no 2814 0.167084287864011 953 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1039 k821-0043 94 µM -0.96580793065736 0.165160370480803 no 2815 0.167070149675022 924 15992768
SGTC_502 l-744,832 89.3 µM -0.967466341712743 0.164749288957658 no 2816 0.16665547968043 931 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_136 0097-0015 404.482 µM -0.968543562164889 0.164482626472915 no 2817 0.166386487040757 928 4861337
SGTC_3277 9138724 49.47 µM -0.969215831870667 0.164316350107668 no 2818 0.16621875677303 908 15943418
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.974784793739679 0.162943139048335 no 2819 0.164833510762256 900 756377
SGTC_844 0330-0132 15.3 µM -0.975450814342885 0.162779410678762 no 2820 0.164668344154932 920 2828079
SGTC_2958 9077254 16.72 µM -0.978072381926412 0.162135988484957 no 2821 0.164019263116186 927 16457351
SGTC_3075 9116269 49.47 µM -0.979172030224277 0.161866590969195 no 2822 0.163747493031489 907 17015205 YNL244C SUI1
SGTC_444 curcumin 90.4 µM -0.9798624032321 0.161697608935532 no 2823 0.163577021805555 905 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1155 4088-0394 48.2 µM -0.980260295610586 0.161600269393249 no 2824 0.163478824094594 916 2326248
SGTC_1820 st053765 18.6 µM -0.981824023856901 0.161218092383918 no 2825 0.163093275302305 921 3690829
SGTC_2971 9092186 9.93 µM -0.981830403276335 0.161216534454999 no 2826 0.163091703620556 916 25236400
SGTC_882 0843-0131 351 µM -0.986006212340795 0.160198860389382 no 2827 0.162065032185526 921 5425421
SGTC_2810 7959871 45.46 µM -0.986972540656906 0.159963959006166 no 2828 0.161828050119144 912 2974535
SGTC_2094 5332512 191.667 µM -0.987408723282162 0.159858002716192 no 2829 0.161721154822902 930 755774
SGTC_3232 9132874 49.47 µM -0.987551252431244 0.159823389879171 no 2830 0.16168623517537 920 3784940
SGTC_1500 4488-1866 171 µM -0.988575194169112 0.159574872401943 no 2831 0.1614355138897 940 2900003
SGTC_1854 st056233 32.9 µM -0.98873313711177 0.159536561125392 no 2832 0.161396862729893 947 5393174
SGTC_994 3910-0338 138 µM -0.989245386396743 0.159412349304894 no 2833 0.161271548680972 918 3479481
SGTC_2443 5493264 126.67 µM -0.989600822573634 0.159326199239421 no 2834 0.161184633898273 942 5340055
SGTC_2843 9000894 45.46 µM -0.99245395497792 0.158635766230808 no 2835 0.160488065091962 881 2242070
SGTC_1737 st035557 69.7 µM -0.994425629667923 0.158159786288242 no 2836 0.160007847791265 913 5716916
SGTC_730 1436-0052 41.2 µM -0.994607750524056 0.158115868018417 no 2837 0.159963538240145 904 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3007 9078383 71.4286 µM -0.995812007801419 0.157825664013384 no 2838 0.159670747427802 928 6496995
SGTC_2006 4011487 200 µM -0.995870153666378 0.157811660780453 no 2839 0.159656619316749 924 45595294
SGTC_732 3970-1727 52.7 µM -0.995885332091468 0.157808005503975 no 2840 0.159652931442363 934 1275699
SGTC_2479 5617353 43.85 µM -0.996884622263432 0.157567478246911 no 2841 0.159410258370548 911 2731746
SGTC_1977 st070720 65.3 µM -0.996992688812688 0.157541481274055 no 2842 0.159384029378662 920 682188
SGTC_2131 toluylene red 5.2905 µM -0.998431512053064 0.157195620107739 no 2843 0.159035079738931 894 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_96 0929-0093 37.281 µM -1.00087153031633 0.156610236016912 no 2844 0.158444461005621 940 6991579
SGTC_1665 st014639 11.4 µM -1.00184910251504 0.156376110110321 no 2845 0.15820823892669 917 981133 YIL048W NEO1
SGTC_2584 androsterone 48.74 µM -1.00293951489743 0.156115231390157 no 2846 0.157945022784494 876 2754130 A steroid.
SGTC_2130 NSC 7 2.4545 µM -1.00655226702711 0.155252938806493 no 2847 0.157074991262704 931 21448
SGTC_324 1315-0088 19.6 µM -1.00996780282651 0.154440614283993 no 2848 0.156255358014916 955 6787421
SGTC_3024 9090631 49.47 µM -1.01024704957451 0.154374324884656 no 2849 0.156188471407898 901 25236383
SGTC_2161 5662504 8.5105 µM -1.01200276631277 0.153957972516428 no 2850 0.155768365378513 896 2859334
SGTC_2382 9035899 200 µM -1.01336843017213 0.153634631906342 no 2851 0.155442106444706 935 6462679
SGTC_2786 7743617 45.45 µM -1.01435744494769 0.153400749320237 no 2852 0.155206111186787 923 583674
SGTC_1749 st037932 54.2 µM -1.01450894985746 0.153364942225489 no 2853 0.15516998051484 957 594497
SGTC_1703 st026983 48.3 µM -1.01550647071643 0.153129323604796 no 2854 0.154932231822355 916 1104023
SGTC_2524 avocatin b 10.57 µM -1.01899956959354 0.15230613091375 no 2855 0.15410158543088 921 6710748
SGTC_1154 4088-0362 150 µM -1.01984205337335 0.152108029531145 no 2856 0.153901687581673 929 6618304
SGTC_3319 9138450 16.7555 µM -1.01997620533425 0.152076500879179 no 2857 0.153869872916746 910 2029690
SGTC_1710 st031758 61.5 µM -1.02034531648057 0.151989774068147 no 2858 0.153782359222551 931 5394341
SGTC_3291 9121177 71.43 µM -1.02071480797427 0.151902990799555 no 2859 0.153694788354854 937 17015612
SGTC_72 0744-0168 198.391 µM -1.0233554409757 0.151283738046817 no 2860 0.15306990967255 960 677577
SGTC_2137 5261020 140 µM -1.02423567061864 0.15107768976071 no 2861 0.152861987127741 916 763655
SGTC_1150 3909-7983 10.9 µM -1.02436399936536 0.151047665569384 no 2862 0.15283168973393 935 23965914
SGTC_575 k072-0246 11.9 µM -1.0250398256972 0.150889612665659 no 2863 0.152672198238526 951 6796779
SGTC_1916 st067606 49.2 µM -1.02515830584142 0.150861915515662 no 2864 0.1526442489203 890 19590279
SGTC_3226 9131256 49.47 µM -1.02608783301063 0.150644737018117 no 2865 0.152425092403079 902 17178073
SGTC_2290 7904846 200 µM -1.0264516591663 0.150559787923888 no 2866 0.152339369260539 935 2962154
SGTC_3045 9092950 49.47 µM -1.02670245668645 0.150501248257394 no 2867 0.152280296071935 938 44120432
SGTC_1298 1079-1278 263 µM -1.02838074498708 0.150109902423777 no 2868 0.151885381176556 945 2840950
SGTC_2955 9076254 12.21 µM -1.02930765895693 0.14989405425973 no 2869 0.151667562702244 928 16459619
SGTC_1944 st076371 56.9 µM -1.03051346616967 0.149613570846639 no 2870 0.151384517079778 923 24208455
SGTC_2415 st077333 57.7 µM -1.03067956170433 0.149574962742619 no 2871 0.151345556123936 908 2766255
SGTC_652 0437-0092 114 µM -1.03081937826184 0.149542468214061 no 2872 0.151312764586018 922 3091274
SGTC_466 geldanamycin 89.2 µM -1.03456389174932 0.148673964779907 no 2873 0.150436312115238 915 5288382 HSP90 inhibitor.
SGTC_16 erodoxin 22.806 µM -1.03546585552236 0.148465267990206 no 2874 0.150225702146984 936 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3282 9108498 15.4605 µM -1.03898642867643 0.147652551586299 no 2875 0.149405524012181 948 16459645
SGTC_500 h-89 112 µM -1.03954607667269 0.147523633114129 no 2876 0.149275420249851 949 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1834 st055981 52.8 µM -1.0404809222409 0.14730845373318 no 2877 0.149058261472641 939 471719 YDL150W RPC53
SGTC_2743 auranofin 4.32 µM -1.04137732188975 0.147102321347264 no 2878 0.148850231722041 918 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1473 k844-0725 134 µM -1.04189160979024 0.146984145160479 no 2879 0.148730967246111 936 54682906
SGTC_1862 st057513 3.81 µM -1.04206336046583 0.146944693436171 no 2880 0.148691152124034 939 5393163
SGTC_2368 9071271 200 µM -1.04263469475558 0.146813507083949 no 2881 0.148558757080826 951 27209959
SGTC_2567 aureobasidin a 60 nM -1.0500444289117 0.145119245856277 no 2882 0.146848843200796 932 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_397 arbidol 50 µM -1.05025553147522 0.145071170096676 no 2883 0.146800322133787 941 131410 A RNA synthesis inhibitor.
SGTC_1220 1838-0075 193 µM -1.0523917393892 0.144585280687931 no 2884 0.146309928537225 916 5529645
SGTC_1440 4100-1550 40 µM -1.05361477691034 0.14430758978706 no 2885 0.146029660517806 951 742806
SGTC_1223 0764-0573 147 µM -1.05461637851632 0.144080443872508 no 2886 0.145800404983994 933 1609797
SGTC_512 prima-1 270 µM -1.05488086140145 0.144020503989664 no 2887 0.145739908171101 941 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_919 tnp00227 403.569 nM -1.05734238876312 0.14346345349478 no 2888 0.14517767709738 960 1269246 A methoxyflavone. YNL221C POP1
SGTC_2068 5226020 147 µM -1.0618520576215 0.142446680881625 no 2889 0.144151426298671 969 1810509
SGTC_1676 st018489 23.4 µM -1.06246245076647 0.142309434025843 no 2890 0.144012897851122 931 3696235
SGTC_3073 9114972 49.47 µM -1.06261013401368 0.142276240904664 no 2891 0.143979394698611 921 41905075
SGTC_2663 amphotericin b 100 µM -1.06550324301003 0.141627045413713 no 2892 0.143324129409696 946 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2947 9072639 7.68 µM -1.06793244851942 0.141083499160773 no 2893 0.14277549211846 983 16488146
SGTC_473 2-arachidonoylglycerol 10 µM -1.06890539216401 0.140866195686207 no 2894 0.142556150999462 924 5282280 An endocannabinoid.
SGTC_511 blebbistatin 171 µM -1.07296035489996 0.139962980379354 no 2895 0.141644452142832 962 3476986 A myosin inhibitor.
SGTC_764 1951-2361 146 µM -1.07304902626054 0.139943273508964 no 2896 0.141624559919032 927 5438930
SGTC_1088 bifonazole 369 nM -1.07500123214763 0.139509880965474 no 2897 0.141187088341325 939 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2863 9028737 58.44 µM -1.07515851800631 0.139475003056522 no 2898 0.141151881937118 937 6460917
SGTC_1924 st058459 75.1 µM -1.07559251135026 0.13937879642989 no 2899 0.141054769017937 939 688683
SGTC_2407 paclitaxel 400 µM -1.0784790755145 0.138740058478094 no 2900 0.140410007392506 981 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.07967054629209 0.138476992445451 no 2901 0.140144457159779 931 6708514
SGTC_3157 9099274 49.47 µM -1.08034270374246 0.13832873618735 no 2902 0.139994800022081 930 17217662
SGTC_2048 5246248 200 µM -1.08262027366058 0.137827182334579 no 2903 0.139488502377666 932 677046
SGTC_1341 1486-1360 280 µM -1.08509640388997 0.137283311951416 no 2904 0.138939479950684 971 3976547
SGTC_2430 5571206 200 µM -1.08615130250274 0.137052054253835 no 2905 0.138706029036027 947 1731771
SGTC_1180 1193-0155 285 µM -1.08692370304654 0.136882895427792 no 2906 0.138535264973339 973 2921347
SGTC_1694 st024011 44.9 µM -1.08764436927631 0.136725195359278 no 2907 0.13837606767765 956 2787533
SGTC_1898 st060199 18.6 µM -1.08881449473006 0.136469406860939 no 2908 0.138117849190378 929 688866
SGTC_676 falcarinol 140 µM -1.0890832704252 0.136410698963494 no 2909 0.138058583307023 946 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3049 9092223 49.47 µM -1.08920249993409 0.136384661539504 no 2910 0.138032298380561 957 8623917
SGTC_623 k072-0108 16.9 µM -1.08958100783588 0.136302025248125 no 2911 0.137948876450893 946 5382803
SGTC_417 st075190 100 µM -1.09181801535106 0.135814338721039 no 2912 0.137456549458206 961 222757
SGTC_1773 st048542 73.5835 µM -1.0924124417984 0.13568494994048 no 2913 0.137325928377256 952 3237138
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.09294572506106 0.135568942072356 no 2914 0.137208815244755 930 6708739 YPR165W RHO1
SGTC_3246 9135460 32.98 µM -1.09402723178724 0.135333885017809 no 2915 0.13697151751373 937 41446951
SGTC_1397 3532-0190 20.1 µM -1.09461104132633 0.135207114734178 no 2916 0.136843538143453 923 5322280
SGTC_581 0958-0271 211 µM -1.09518096932564 0.135083437289305 no 2917 0.136718680670036 950 4591145
SGTC_1636 st007707 68.9 µM -1.095907357275 0.134925919674354 no 2918 0.136559659521676 961 403051
SGTC_1838 st055369 84.5 µM -1.09635562467041 0.134828775542811 no 2919 0.136461587780382 944 676036
SGTC_3027 9089541 49.47 µM -1.10024778174999 0.133987322385334 no 2920 0.135612088508966 957 9943819
SGTC_3044 9093193 49.47 µM -1.10167566990344 0.13367953108093 no 2921 0.135301349009195 934 25236277
SGTC_343 4130-2827 29.8 µM -1.10233730306059 0.13353707635399 no 2922 0.135157528856175 958 1118244
SGTC_1004 4084-0029 199 µM -1.10311875707723 0.133368957785963 no 2923 0.134987798128502 946 716894 YLR208W SEC13
SGTC_1398 3558-0053 112 µM -1.10348003600262 0.133291283071357 no 2924 0.134909378285466 939 4532369
SGTC_615 k087-0205 167 µM -1.10492478004369 0.132980975259493 no 2925 0.134596091989029 951 9642773
SGTC_1573 oleylamine 1.06 µM -1.10628973651731 0.132688261752839 no 2926 0.134300566349721 953 5356789 An amine of the fatty acid oleic acid.
SGTC_1091 telmisartan 47.6 µM -1.10806175154568 0.132308917449749 no 2927 0.133917573988493 975 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2420 aureobasidin a 50 nM -1.10906238811911 0.132095036624964 no 2928 0.133701634505976 957 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_305 1682-2595 20.8 µM -1.11012646338825 0.131867857797971 no 2929 0.133472267585997 943 226033
SGTC_3048 9093155 49.47 µM -1.11072336201328 0.131740538705573 no 2930 0.133343721560081 914 25236002
SGTC_2921 7974240 10.71 µM -1.11147389260539 0.131580570165679 no 2931 0.133182210793747 955 2979074 YDR527W RBA50
SGTC_3262 9137218 49.47 µM -1.11319588897603 0.131214049655177 no 2932 0.132812153952504 924 17650664
SGTC_1340 1486-1359 257 µM -1.11357107062569 0.131134287281062 no 2933 0.132731621487956 926 4309068
SGTC_1730 st033808 45.1 µM -1.11368766326316 0.131109506895831 no 2934 0.132706601815545 951 1045166
SGTC_175 3793-3120 23.7 µM -1.11532207749926 0.130762471979473 no 2935 0.132356213961814 961 5322297
SGTC_798 1287-0182 476 µM -1.1156287078332 0.130697436008901 no 2936 0.132290549248707 980 1649755
SGTC_1948 st076329 66.6 µM -1.11646703248804 0.130519742386701 no 2937 0.13211113713129 953 24208413
SGTC_1286 0929-0070 131 µM -1.11714488198224 0.130376185735794 no 2938 0.131966191462121 955 1420408
SGTC_2658 polymyxin b sulfate 77.05 µM -1.11885665592793 0.130014148281106 no 2939 0.131600648379801 963 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2185 6113692 200 µM -1.1191507381002 0.129952020483639 no 2940 0.13153791861476 965 874150
SGTC_662 k832-1615 104 µM -1.12060816110179 0.129644428632266 no 2941 0.131227344804849 965 5878478
SGTC_1010 4112-3296 15.2 µM -1.12270856450501 0.129202022248027 no 2942 0.13078064469474 959 704384
SGTC_185 k048-0037 25.491 µM -1.12458981543373 0.128806665168658 no 2943 0.130381445719807 951 6827589
SGTC_2861 9024595 19.48 µM -1.12495451994889 0.128730117372817 no 2944 0.130304153544007 951 16482810
SGTC_1400 3771-8998 51.5 µM -1.12804984586971 0.128081710338106 no 2945 0.129649434321825 956 670767
SGTC_247 mechlorethamine 29.705 µM -1.1307891380313 0.127509780246591 no 2946 0.129071926382884 940 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_24 0417-1663 219 µM -1.13088597701422 0.127489594023693 no 2947 0.129051543116163 992 4329390
SGTC_1258 0671-0043 57.1 µM -1.13152510693675 0.127356422219674 no 2948 0.128917071084042 969 4298767
SGTC_450 aminopyrene 156 nM -1.13452357717688 0.126732940224113 no 2949 0.128287494810837 958 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3234 9132280 49.47 µM -1.13572027760335 0.12648470066273 no 2950 0.128036825648106 955 17612295
SGTC_124 0136-0217 7.121 µM -1.13710682708272 0.126197503298351 no 2951 0.127746815139146 955 3976905
SGTC_992 3909-8734 162 µM -1.14113087965225 0.125366572238409 no 2952 0.126907731355981 981 4288319
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.14312113751239 0.124957016370427 no 2953 0.126494149648528 962 688662
SGTC_1534 6-azauridine 81.6 µM -1.14547256106801 0.124474345343405 no 2954 0.126006727739736 970 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_143 4032-1194 15.74 µM -1.14628411879478 0.124308061842255 no 2955 0.125838805937068 958 1806963
SGTC_121 0557-0495 61.343 µM -1.14774323675033 0.124009487884292 no 2956 0.125537288243855 980 3104427
SGTC_1778 st046819 58.9 µM -1.14948087089399 0.123654577302388 no 2957 0.125178875061585 971 671715
SGTC_1092 toremifene 6.32 µM -1.14997169200904 0.123554456378139 no 2958 0.125077765374074 990 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3231 9132313 49.47 µM -1.15183830143578 0.123174211675381 no 2959 0.124693762790157 954 4905967
SGTC_3195 9113082 49.47 µM -1.15522737143325 0.12248592633421 no 2960 0.123998664369237 971 17018038
SGTC_2346 9031566 143.75 µM -1.15790298585893 0.121944446213452 no 2961 0.123451814454384 970 4771086
SGTC_650 1328-0195 38 µM -1.16287450153336 0.120942800071271 no 2962 0.122440212099515 970 2780821
SGTC_1421 4029-0249 71.4 µM -1.16436920980793 0.12064278583785 no 2963 0.122137209943523 971 2894095
SGTC_2506 ethyl hematommate 54.16 µM -1.16454540230564 0.120607455457456 no 2964 0.122101527521303 961 3940691 An allergen.
SGTC_1071 trifluoperazine 6.31 µM -1.169167815855 0.119683163779173 no 2965 0.12116801266587 997 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_949 1165-0505 146 µM -1.1699190166758 0.119533427820023 no 2966 0.121016780134566 975 6244267
SGTC_2638 epoxomicin 18 µM -1.17318777134014 0.118883409665973 no 2967 0.120360257408664 953 9915668 A protesome inhibitor.
SGTC_2027 5150920 200 µM -1.17375961054112 0.118769951899136 no 2968 0.1202456629952 934 786715
SGTC_1186 1319-0216 26 µM -1.17395141441357 0.118731913513661 no 2969 0.120207243445471 968 4565136
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.17456678604551 0.118609931623671 no 2970 0.120084038940048 963 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_710 3448-4187 58 µM -1.17532520629857 0.118459715813413 no 2971 0.119932316911888 959 3946412
SGTC_3119 9125183 49.47 µM -1.17591219970005 0.118343545850185 no 2972 0.119814981642936 939 22695334
SGTC_1961 st076550 68.7 µM -1.17744285528394 0.118040997653161 no 2973 0.119509396661582 970 1579337
SGTC_1700 st030840 7.9285 µM -1.17763556271924 0.118002946061062 no 2974 0.119470962936459 969 5499307
SGTC_2292 7671323 168.05 µM -1.18000537625147 0.117535717156949 no 2975 0.118999038320454 976 937504
SGTC_3200 9114385 49.47 µM -1.18105795422702 0.117328613056599 no 2976 0.11878985068479 951 17018030 YLR208W SEC13
SGTC_2295 7971645 200 µM -1.19232957210003 0.115127013426372 no 2977 0.116566021745615 997 2978226 YKL099C UTP11
SGTC_1493 4348-0038 111 µM -1.19393849061925 0.114815167123349 no 2978 0.116251014824883 967 800424
SGTC_3336 9143619 71.43 µM -1.19502689916556 0.114604548963725 no 2979 0.116038260330435 992 45595730
SGTC_1911 st060208 74.3 µM -1.19658490272993 0.114303538108647 no 2980 0.115734193915379 981 688783
SGTC_491 tetrandrine 80.3 µM -1.2038653858359 0.112904389639297 no 2981 0.114320806193945 985 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2127 5253358 187.912 µM -1.20438887715148 0.112804259336839 no 2982 0.114219654547722 972 20612
SGTC_2825 7998094 58.44 µM -1.20902968067641 0.111919365646307 no 2983 0.113325721360324 979 2987815
SGTC_1630 st005209 31.3 µM -1.21036873446762 0.111664964337801 no 2984 0.11306871677343 958 3367314
SGTC_1183 1254-0324 198 µM -1.21917268299847 0.110002636417616 no 2985 0.111389328871191 968 5799357
SGTC_1946 st076057 65.1 µM -1.21923280746646 0.109991345321055 no 2986 0.111377921603376 972 953009
SGTC_3133 9127736 49.47 µM -1.21976753831877 0.109890961929266 no 2987 0.111276505217219 951 27243420
SGTC_3253 9135987 49.47 µM -1.21986226914594 0.109873185257727 no 2988 0.111258545582232 976 4182430
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.22106508740138 0.109647650374151 no 2989 0.111030688561597 987 689007
SGTC_2525 harmine 47.85 µM -1.22319444299972 0.109249200176071 no 2990 0.110628131982772 944 5280953 A monoamine oxidase inhibitor
SGTC_3180 9109287 49.47 µM -1.22323724487907 0.109241201663881 no 2991 0.110620050988017 954 18891271
SGTC_899 1083-0020 478 µM -1.2241493228414 0.109070858990115 no 2992 0.110447951224521 992 767123
SGTC_2184 6075246 200 µM -1.22465222068952 0.108977017824618 no 2993 0.110353141696448 958 2267320
SGTC_1035 k081-0041 55.2 µM -1.22527641429927 0.108860623505334 no 2994 0.110235545901493 965 731709
SGTC_202 3594-0513 34.79 µM -1.22785003936173 0.108381659783232 no 2995 0.109751633623983 985 708429
SGTC_114 0364-0001 490.298 µM -1.2287965428239 0.108205892986223 no 2996 0.109574049033663 1006 4003655
SGTC_2866 9034245 58.44 µM -1.22901391538842 0.108165555634442 no 2997 0.109533294372998 969 6462273
SGTC_1403 3909-7815 62.9 µM -1.23082166686774 0.107830514417504 no 2998 0.109194785019042 958 6615483
SGTC_367 0335-0881 7.1 µM -1.23245534176519 0.107528379391824 no 2999 0.108889519449953 995 23828853
SGTC_1671 st016596 74.5 µM -1.23432346771492 0.107183632781347 no 3000 0.108541197264354 990 2829167
SGTC_3127 9126946 49.47 µM -1.23445999504991 0.107158469121605 no 3001 0.108515772470221 957 27243249
SGTC_196 k015-0023 18.111 µM -1.23525580954558 0.107011875552032 no 3002 0.10836765723691 964 5211998
SGTC_1016 4226-1401 38 µM -1.2419153131886 0.105790824212959 no 3003 0.107133904770333 979 2901613
SGTC_293 4049-0273 38.5 µM -1.24203203031395 0.105769513756328 no 3004 0.107112372226836 966 1380311
SGTC_2627 acetyl isogambogic acid 100 µM -1.2460494172248 0.105037901475206 no 3005 0.106373126689514 985 6857789 A caspase activator and apoptosis inducer.
SGTC_1270 0831-1170 17.3 µM -1.24782175014307 0.104716306365121 no 3006 0.106048170830355 976 6764716
SGTC_1405 3909-7894 12 µM -1.24807077680911 0.104671176929895 no 3007 0.106002569517206 948 7104060
SGTC_1721 st082152 9.2685 µM -1.24820467582314 0.104646917132448 no 3008 0.105978056029996 977 5296051
SGTC_3205 9113483 49.47 µM -1.24866118763278 0.104564237023832 no 3009 0.105894511177038 974 17018033
SGTC_2595 hexamethylquercetagetin 100 µM -1.24981545863439 0.104355394947541 no 3010 0.105683483866238 1002 386331
SGTC_3236 9132701 49.47 µM -1.25216963933152 0.103930390674703 no 3011 0.105254028221143 1011 24282524
SGTC_93 0109-0045 59.227 µM -1.25348673699183 0.103693161089139 no 3012 0.105014311445245 996 88733
SGTC_1828 st055811 49 µM -1.25525894839941 0.103374578803439 no 3013 0.104692386201552 984 5877589
SGTC_2466 5983409 37.09 µM -1.25636625081955 0.10317588516021 no 3014 0.104491605969316 1007 2879657
SGTC_2257 7960413 200 µM -1.25896833737848 0.102710060318183 no 3015 0.104020884271426 962 2974689 YIL048W NEO1
SGTC_2659 sanguinarine 24.21 µM -1.26409551564245 0.101796671101528 no 3016 0.103097872992149 956 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2129 girgensonine 121.053 µM -1.26429104952657 0.101761954836626 no 3017 0.103062790478328 992 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3016 9080866 49.47 µM -1.26498707736168 0.101638447803997 no 3018 0.102937980157557 991 17066299
SGTC_784 4579-0127 173 µM -1.26606621194086 0.101447176044943 no 3019 0.102744689059024 988 1948547
SGTC_2474 5321570 43.32 µM -1.26690276605115 0.101299081087706 no 3020 0.102595029784245 999 2841384
SGTC_2986 9022445 71.43 µM -1.26709782398751 0.101264572688479 no 3021 0.102560156772838 960 6459286
SGTC_2946 9065502 71.43 µM -1.26855606784179 0.101006860882375 no 3022 0.102299720788525 927 16489101
SGTC_2204 7233102 200 µM -1.26859345460663 0.101000259904111 no 3023 0.102293050005388 964 2172480
SGTC_1454 4239-0054 42.6 µM -1.27203112521452 0.100394650499383 no 3024 0.101681030297662 990 1340767
SGTC_3004 9076122 71.4286 µM -1.27316295524346 0.100195838674336 no 3025 0.101480111470237 993 44782551
SGTC_2311 7694451 200 µM -1.27320020551637 0.100189300358924 no 3026 0.101473503840053 1002 2163142
SGTC_1788 fluconazole 20 µM -1.27357024854251 0.100124365855973 no 3027 0.101407880870003 982 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1531 st059297 52.4 µM -1.27652234153469 0.0996074377605366 no 3028 0.100885467143528 989 7566702
SGTC_1508 1080-0625 72.9 µM -1.2770922204425 0.0995078737340322 no 3029 0.100784845542684 955 767111
SGTC_1850 st056238 17 µM -1.27832038525926 0.0992935473509832 no 3030 0.100568241472923 968 5393177
SGTC_250 brefeldin a 552.239 µM -1.27858683669572 0.0992470936420018 no 3031 0.10052129389336 995 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3330 9141424 71.43 µM -1.28184355855648 0.0986805934629943 no 3032 0.0999487653009222 977 27261020
SGTC_1295 1013-0063 9.78 µM -1.28343302613715 0.0984049697804488 no 3033 0.0996702047581739 994 6826038
SGTC_826 1683-5028 118 µM -1.28482881745345 0.0981633960279816 no 3034 0.0994260549041587 983 722377
SGTC_2612 dictamnine 15.46 µM -1.28554122176976 0.0980402656828545 no 3035 0.0993016107787227 952 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2847 9005661 71.43 µM -1.2860385074897 0.0979543830425839 no 3036 0.0992148114892657 977 2991449
SGTC_1982 st072467 71.9 µM -1.28702430086843 0.0977842967604932 no 3037 0.0990429091116014 989 3163533
SGTC_1424 4048-1941 275 µM -1.28744525691521 0.0977117320765441 no 3038 0.0989695693281524 984 X1424
SGTC_968 1309-0633 340 µM -1.29040196431201 0.0972031651181371 no 3039 0.0984555652328594 985 3761976
SGTC_2052 5265182 7.135 µM -1.29084315740505 0.0971274447715767 no 3040 0.0983790346216576 977 1239884
SGTC_2215 7188065 200 µM -1.29175568225388 0.0969709688715801 no 3041 0.098220883710545 997 940217
SGTC_2738 aclarubicin 5.55 µM -1.29432587043749 0.0965312386767448 no 3042 0.0977764420382083 1001 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2740 felodipine 17.08 µM -1.29519199261914 0.096383385459854 no 3043 0.0976270032107037 988 3333 L-type calcium channel blocker
SGTC_737 1950-0117 57.9 µM -1.29858847295719 0.0958051879219744 no 3044 0.0970425979765149 994 5393513
SGTC_2935 9038016 29.96 µM -1.29895542171289 0.0957428736938458 no 3045 0.096979614060458 976 6463195
SGTC_462 ag-879 158 µM -1.2993912579354 0.0956688999316347 no 3046 0.0969048451378777 998 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_997 3996-0078 137 µM -1.29952299901309 0.0956465480150982 no 3047 0.0968822529197464 982 735687
SGTC_2435 5706476 10.6 µM -1.30012667528975 0.0955441741192813 no 3048 0.0967787782069454 971 5725375
SGTC_3076 9116187 49.47 µM -1.30323175310154 0.0950188762141841 no 3049 0.0962478263184756 981 27241210
SGTC_3237 9133362 49.47 µM -1.30705119727198 0.0943756479026357 no 3050 0.0955976621192944 1011 43845137
SGTC_190 3970-0790 3.722 µM -1.30739977805444 0.0943171040912876 no 3051 0.0955384863452228 993 2832352
SGTC_1610 st001799 48.1 µM -1.30813999998948 0.0941928733554956 no 3052 0.0954129141950503 999 621897
SGTC_695 3505-6186 243 µM -1.3092540848754 0.0940061251729964 no 3053 0.0952241485738531 991 1819379
SGTC_2600 tangeritin 87.95 µM -1.30969547333454 0.093932213162944 no 3054 0.0951494377692594 987 68077 A bioactive flavone.
SGTC_391 gliotoxin 8.33 µM -1.31164552950846 0.0936061828341151 no 3055 0.0948198817154797 990 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1738 st035555 74 µM -1.31409981680131 0.0931970386150471 no 3056 0.0944063079009357 990 5331140
SGTC_2469 5655019 90.81 µM -1.31723243774371 0.0926767339412257 no 3057 0.0938803619874441 997 2788239
SGTC_2101 5377231 179.231 µM -1.3176709340708 0.0926040747655183 no 3058 0.0938069142986286 1007 2844213
SGTC_3040 9091894 49.47 µM -1.3176891479395 0.0926010576253448 no 3059 0.0938038644119299 973 25236966
SGTC_3117 9124945 49.47 µM -1.31783569462324 0.0925767847101636 no 3060 0.0937793280394899 973 17592065
SGTC_2330 7979373 200 µM -1.32106837909016 0.0920425430523222 no 3061 0.0932392826849097 983 1863007
SGTC_607 4491-0986 66.8 µM -1.32269821739185 0.0917740589830378 no 3062 0.0929678782983741 951 698981 YDR232W HEM1
SGTC_2989 9073649 71.4286 µM -1.32328046158053 0.0916782863907501 no 3063 0.092871063388591 994 21367202
SGTC_2902 5787006 60.46 µM -1.32651144799747 0.0911481708908498 no 3064 0.092335172855086 982 591003
SGTC_3213 9129884 49.47 µM -1.32829065462195 0.0908572245784082 no 3065 0.0920410529222034 993 17190742
SGTC_410 α-linolenic acid 100 µM -1.33023296262627 0.090540394307934 no 3066 0.0917207633988258 1002 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2837 9008476 45.46 µM -1.33091200608367 0.0904298221122458 no 3067 0.0916089831319762 992 2992805
SGTC_435 c-PAF 6.7 µM -1.33328438296195 0.0900443026450723 no 3068 0.0912192483419301 983 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_342 k048-0088 23.3 µM -1.33359034534406 0.0899946717338933 no 3069 0.0911690743889109 992 6820570
SGTC_2523 spermine 47.74 µM -1.33520223919054 0.0897335380626403 no 3070 0.090905082101668 980 1103 A DNA binding polyamine.
SGTC_2667 digitoxin 100 µM -1.33749116270294 0.0893636911795098 no 3071 0.0905311825100055 956 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_266 formosanin C 406 nM -1.33857317318585 0.0891892539193586 no 3072 0.0903548321651964 964 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_856 0433-0016 11.3 µM -1.34111988950762 0.0887796830453361 no 3073 0.0899407653255207 1000 3911780
SGTC_1292 0kpi-0043 232 µM -1.34219373184867 0.0886074047646333 no 3074 0.0897665941688664 996 3333905
SGTC_1654 st012436 41.8 µM -1.34224041345683 0.0885999212098438 no 3075 0.0897590283666161 1023 4323132
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.34293137071138 0.0884892085150531 no 3076 0.0896470986655101 984 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.34417372549733 0.0882904042249411 no 3077 0.0894461079586468 1012 165521
SGTC_89 0302-0250 142.109 µM -1.34488600001198 0.0881765747562455 no 3078 0.0893310259952895 1018 4203518 YLR208W SEC13
SGTC_2499 avocadenofuran 51.48 µM -1.34603150868538 0.0879937390986633 no 3079 0.0891461776091219 998 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3002 9075603 71.4286 µM -1.34796351178559 0.0876860110649102 no 3080 0.0888350593586212 977 20105405
SGTC_2148 5546263 113.568 µM -1.34833953170075 0.087626212341455 no 3081 0.0887746014548961 1021 792097
SGTC_1063 disulfiram 1.84 µM -1.35192806793534 0.08705705490061 no 3082 0.0881991637748989 1005 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_442 cape 100 µM -1.35842464089282 0.0860337014869612 no 3083 0.0871644899183612 1009 5281787
SGTC_389 tpck 16.7 µM -1.36039534327972 0.0857250586731475 no 3084 0.0868524256545091 1021 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1339 1486-1321 22.7 µM -1.36123564019433 0.0855937073931742 no 3085 0.086719617267566 1001 3469382
SGTC_1521 st012942 49.4 µM -1.36576504003761 0.0848882872174876 no 3086 0.0860063613139565 988 24207259
SGTC_3271 9137798 49.47 µM -1.36662061735044 0.0847555282549596 no 3087 0.0858721257050531 950 6498326
SGTC_2504 purpurogallin 52.29 µM -1.37163624338227 0.0839803892998418 no 3088 0.0850883525946229 999 5281571 An antioxidant.
SGTC_7 0192-1582 4.227 µM -1.3761902713257 0.0832812097244644 no 3089 0.0843813666417313 1027 252616
SGTC_2747 doxorubicin 7.63 µM -1.37757274289175 0.0830698272606143 no 3090 0.0841676206486217 953 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_449 xestospongin c 11.1929 µM -1.38338236718063 0.0821859341405843 no 3091 0.0832738271326584 1008 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2744 captopril 92.04 µM -1.38468609640984 0.08198855777168 no 3092 0.083074236141405 1020 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2700 st077718 96.8 µM -1.38540683450164 0.0818795959920717 no 3093 0.0829640511773185 998 904970
SGTC_2298 7976326 193.81 µM -1.39096938717006 0.0810423132662514 no 3094 0.0821173549868319 1021 2235818
SGTC_1001 4048-4355 44.4 µM -1.39236675999594 0.080832997934437 no 3095 0.0819056823893951 1000 21824233
SGTC_2189 6047310 154.431 µM -1.39417153348403 0.0805632615648224 no 3096 0.0816329059630796 1002 711535
SGTC_934 2950-0684 338 µM -1.40039783149728 0.0796379143239729 no 3097 0.0806971095185705 999 1121253
SGTC_2746 daunorubicin 9.88 µM -1.40410740635698 0.0790904359909317 no 3098 0.0801434342410885 992 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1094 duloxetine 25.4 µM -1.40525618734745 0.0789214722333557 no 3099 0.079972555755045 1009 60834 A selective serotonin reuptake inhibitor.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.41033835356115 0.0781772618434378 no 3100 0.0792198993548314 970 279621
SGTC_1805 st050013 60.3 µM -1.41051988936313 0.0781507773305475 no 3101 0.0791931138947734 994 4037144
SGTC_518 1021-0119 62.6 µM -1.41177216001612 0.0779682671761455 no 3102 0.0790085291489675 1002 1097762
SGTC_3207 9114163 49.47 µM -1.4141859938394 0.0776173796537074 no 3103 0.0786536496354406 1016 849233
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.41558459426753 0.0774146210881521 no 3104 0.0784485822422939 999 77254
SGTC_2697 mebhydrolin 72.4 µM -1.41694645931343 0.0772175749579875 no 3105 0.078249290873257 1016 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_864 0469-0573 172 µM -1.4176565487152 0.0771149844880811 no 3106 0.0781455308679203 1034 689425
SGTC_1492 4158-0558 28.5 µM -1.41877194869565 0.0769540457711059 no 3107 0.0779827566559265 974 3967268
SGTC_1115 galangin 695.678 nM -1.42284545427343 0.0763684565211544 no 3108 0.0773904806709777 1025 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3140 9094243 49.47 µM -1.4241699315414 0.0761787877548152 no 3109 0.0771986433719712 1013 19291112
SGTC_2937 9044753 11.33 µM -1.42820694949689 0.0756028875100485 no 3110 0.0766161504678545 982 6465530 YGL099W LSG1
SGTC_2412 st077135 33.4 µM -1.43082616170297 0.0752310221933315 no 3111 0.0762400215916406 1023 13258915
SGTC_2791 5663188 71.43 µM -1.43549644936089 0.0745714157077923 no 3112 0.0755728397021973 1006 54690634
SGTC_1971 st069429 63.5 µM -1.43690329927869 0.0743735873793102 no 3113 0.0753727361690925 1002 1246522 YGL099W LSG1
SGTC_1334 1486-0610 236 µM -1.43732152762903 0.0743148543093367 no 3114 0.0753133273309167 997 3742339
SGTC_632 0781-2353 4.65 µM -1.43873871403305 0.0741160978724691 no 3115 0.0751122830832756 1037 6811515 YHR007C ERG11
SGTC_3013 9080133 71.4286 µM -1.43947785825418 0.0740125962094202 no 3116 0.0750075894590259 1016 17050193
SGTC_3222 9128301 49.47 µM -1.44554993007824 0.0731665053574315 no 3117 0.0741517394757939 985 4911358
SGTC_2192 5915882 198.485 µM -1.44731742001519 0.0729216168029636 no 3118 0.0739040211976623 1011 2876149
SGTC_1418 3966-3099 2.4 µM -1.44788348406795 0.0728433205153977 no 3119 0.0738248197017619 1005 740335
SGTC_2634 4'-methoxyflavone 100 µM -1.44931252994014 0.0726459455022573 no 3120 0.0736251617331487 1014 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2886 9058944 51.95 µM -1.45378450957509 0.0720309366215174 no 3121 0.0730030297277567 998 4949929
SGTC_1941 st076221 61.8 µM -1.45503351957049 0.0718598816882067 no 3122 0.0728299910290764 977 2828568
SGTC_2977 9011197 71.43 µM -1.45747291194685 0.0715266995883529 no 3123 0.0724929417017098 1001 2704722
SGTC_2536 dehydroabietamide 32.04 µM -1.46272905126031 0.0708128249944132 no 3124 0.0717707667702234 1018 3983547
SGTC_2619 obliquin 87.91 µM -1.47111426584193 0.0696853170563068 no 3125 0.0706301088131493 993 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1668 st014914 51.6 µM -1.47191333780327 0.0695785961731382 no 3126 0.0705221406854919 1028 2839556
SGTC_1666 st014829 29 µM -1.47653962546717 0.0689631992380485 no 3127 0.069899542914036 1036 3858230
SGTC_2910 7948405 25.97 µM -1.47707766634779 0.0688919012851764 no 3128 0.0698274097337706 982 2971328
SGTC_474 dl-dihydrosphingosine 5 µM -1.47884873588287 0.0686576111020782 no 3129 0.0695903735248206 991 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_218 alverine citrate 93.75 µM -1.48054231500084 0.06843414713139 no 3130 0.069364288402742 1006 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2522 biochanin a 4.94 µM -1.48258975817216 0.068164741334731 no 3131 0.0690917199527121 1017 5280373 A possible chelator.
SGTC_3111 9122088 49.47 µM -1.48366339846969 0.0680237976251677 no 3132 0.0689491205098141 1009 16876704
SGTC_477 mead ethanolamide 10 µM -1.48418811889763 0.067954996084559 no 3133 0.0688795104388599 1030 16061185
SGTC_2828 7998861 71.43 µM -1.49033375044921 0.067153173452419 no 3134 0.0680682512281228 996 2988188
SGTC_62 0180-0423 3.232 µM -1.49675987317912 0.0663225996193656 no 3135 0.0672278754192971 1024 30102 YGL099W LSG1
SGTC_1866 st057638 64 µM -1.49806715287882 0.0661546121295261 no 3136 0.0670579020739332 996 688802
SGTC_589 1227-0070 34.1 µM -1.50495748475201 0.0652746350245175 no 3137 0.0661675038039889 1033 2841384
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.50867719688838 0.0648033728568253 no 3138 0.065690647826395 1002 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2973 9094665 17.96 µM -1.51745448306792 0.0637018240619648 no 3139 0.0645759885724903 1006 25237061 YIL048W NEO1
SGTC_2980 9014342 25.29 µM -1.51877252082966 0.0635376758931264 no 3140 0.0644098824918477 987 2996599
SGTC_671 0560-0003 407 µM -1.52276140879908 0.0630429056426924 no 3141 0.0639092040696722 1034 3238678
SGTC_2089 5281248 129.67 µM -1.52650303906389 0.0625815370604345 no 3142 0.0634423170850659 1014 2737878
SGTC_2820 7989630 71.43 µM -1.52691683969475 0.0625306746722406 no 3143 0.0633908457966018 1002 2984098
SGTC_2686 alizarin 95.37 µM -1.53914501930003 0.0610421447268332 no 3144 0.0618844482716025 1012 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_478 N-arachidonylglycine 10 µM -1.54036167974952 0.0608955692283418 no 3145 0.0617361083495943 1048 5283389
SGTC_559 1550-0661 158 µM -1.5410021050617 0.0608185254933948 no 3146 0.0616581368282231 1023 5830875
SGTC_1742 st038235 28.8875 µM -1.54551495398282 0.0602777847860297 no 3147 0.0611108773162555 1025 564103 YBR002C RER2
SGTC_699 0375-0592 111 µM -1.54667509652766 0.0601393834892985 no 3148 0.0609708055662675 1008 762578
SGTC_258 haloperidol 50.781 µM -1.54750763871668 0.0600402172904572 no 3149 0.06087044196993 1025 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_416 estradiol valerate 100 µM -1.54794799370226 0.0599878172970066 no 3150 0.0608174090968233 1027 13791 A steroid.
SGTC_2175 5807670 165.306 µM -1.55021346997776 0.0597188030671423 no 3151 0.0605451439213518 994 241186
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.55433798396607 0.0592314650847291 no 3152 0.0600519088046745 1015 3256 An antibiotic and ribosome inhibitor.
SGTC_2235 salicylic acid 500 µM -1.55497722546712 0.0591562144924475 no 3153 0.0599757467265917 1045 338 A COX inhibitor and kinase inhibitor.
SGTC_415 dibenzyl ketone 100 µM -1.55703219648567 0.0589148141230367 no 3154 0.0597314207238122 1026 7593
SGTC_2019 4016004 108 µM -1.55816218897307 0.0587824020477686 no 3155 0.0595974028337951 1016 45595336
SGTC_791 1348-1292 225 µM -1.5607928451006 0.0584750475990986 no 3156 0.0592863180820094 1039 5437054
SGTC_2540 epiandrosterone 100 µM -1.56468157547127 0.0580230184184154 no 3157 0.0588287953450497 1024 441302 A steroid.
SGTC_2384 9036245 200 µM -1.56773405483323 0.0576701232447948 no 3158 0.0584716052869629 1005 6462766
SGTC_2252 omeprazole 400 µM -1.56789608785163 0.0576514379905762 no 3159 0.0584526924754316 1040 4594 A proton pump inhibitor.
SGTC_328 k915-0120 63.5 µM -1.56886379774723 0.0575399431422157 no 3160 0.0583398394797057 1026 6624543
SGTC_2918 7977171 22.06 µM -1.56947173163249 0.0574699867311806 no 3161 0.0582690306371935 1010 2236483
SGTC_785 1270-0111 65.3 µM -1.5747282765056 0.0568678905265983 no 3162 0.0576595890109163 1011 6741994
SGTC_234 nsc-17383 10.7 µM -1.5770202388219 0.056606924267469 no 3163 0.0573954341330306 1012 408974
SGTC_2360 9040895 200 µM -1.58016479327589 0.0562504169988273 no 3164 0.0570345660730598 1023 4914414
SGTC_2020 4017018 200 µM -1.58107493874729 0.0561475621582247 no 3165 0.056930452080258 1036 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2054 5233173 129 µM -1.58319180712894 0.0559089100826902 no 3166 0.056688876631948 897 6889
SGTC_1776 st049249 45.9 µM -1.58422293130312 0.0557929531159755 no 3167 0.0565714983456695 1043 1822314
SGTC_2840 9008771 71.43 µM -1.58523832749423 0.055678950395133 no 3168 0.0564560976826768 1023 2992978
SGTC_535 2293-4129 48.2 µM -1.58743485422659 0.05543296629478 no 3169 0.0562070952874817 1045 396118 YIL048W NEO1
SGTC_2241 6772625 37.8075 µM -1.5877669421502 0.0553958512966027 no 3170 0.0561695246460722 1009 2285411
SGTC_2061 5245884 80.95 µM -1.59281560699486 0.054834012954581 no 3171 0.0556007814417169 1050 573863
SGTC_2238 6671620 73.2395 µM -1.59283043844916 0.0548323691031839 no 3172 0.0555991173672516 1016 729941
SGTC_2363 9053361 176 µM -1.5986427184217 0.0541911553228198 no 3173 0.0549500060490848 1041 6469797 YMR079W SEC14
SGTC_1615 st002656 86.5 µM -1.60182855672598 0.0538422178720799 no 3174 0.0545967631865633 1044 1584458
SGTC_2508 celastrol 40.54 µM -1.60413647572287 0.0535905499505893 no 3175 0.0543419866403019 996 122724 Celastrol is a natural product and antioxidant.
SGTC_56 0957-0365 83.25 µM -1.60986732493482 0.0529696566374466 no 3176 0.0537134118106072 1032 6752360
SGTC_283 0987-0079 11.7 µM -1.63037790203852 0.0507941242307204 no 3177 0.0515108260540215 1035 411556
SGTC_2759 disulfiram 3.38 µM -1.63117831242479 0.0507106900841185 no 3178 0.0514263500538353 1015 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_793 0488-0545 106 µM -1.63212020597132 0.0506126476710239 no 3179 0.0513270829598849 1038 292548
SGTC_3085 9117376 49.47 µM -1.63813143104862 0.0499904865257617 no 3180 0.0506971397879491 1031 16480349
SGTC_2315 7733312 200 µM -1.64363274207988 0.0494264604392079 no 3181 0.0501260432279507 1029 726316
SGTC_2518 prenyletin 46.28 µM -1.64529540636998 0.0492569978094156 no 3182 0.0499544533487748 1031 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_869 0564-0080 44.1 µM -1.64684771551586 0.0490992019224924 no 3183 0.0497946754498119 1038 6843321
SGTC_2670 beta-carotene 100 µM -1.65148735577185 0.0486299774092011 no 3184 0.0493195502536584 1014 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_333 3486-0131 40.1 µM -1.65293452503282 0.0484843553725703 no 3185 0.0491720948450646 1025 6744690
SGTC_2952 9073731 13.78 µM -1.65770230987273 0.0480070603880241 no 3186 0.0486887836872984 1037 16457353
SGTC_292 k038-0015 474 µM -1.66071334582516 0.0477075730737052 no 3187 0.0483855158732771 1046 46368540
SGTC_2585 alliin 100 µM -1.66165942735718 0.0476137822837084 no 3188 0.0482905402579078 1042 87310 A garlic compound which reacts with lipids.
SGTC_1158 4092-0494 91.8 µM -1.66417524438235 0.0473650925253203 no 3189 0.0480387068497774 1045 1148199
SGTC_803 4488-1585 147 µM -1.66706569490628 0.0470806561190382 no 3190 0.0477506712826191 1020 747204
SGTC_1364 1653-0028 37.6 µM -1.67448682430911 0.0463566447120742 no 3191 0.0470174808565743 1029 5718652
SGTC_2770 toltrazuril 17.5 µM -1.67736752017924 0.0460780213309187 no 3192 0.0467353183090951 1016 68591 Kills coccidiodes.
SGTC_3240 9133527 49.47 µM -1.67827925913165 0.045990117935966 no 3193 0.0466462975510562 1033 17617455
SGTC_198 3454-2873 16.191 µM -1.67850227068182 0.0459686372658318 no 3194 0.0466245437771526 1035 710957
SGTC_2477 5967686 25.23 µM -1.68492374938125 0.0453535649739527 no 3195 0.0460016419154997 1046 776118
SGTC_959 1222-0044 107 µM -1.68566280093183 0.0452832027386901 no 3196 0.0459303828195992 1029 6083612
SGTC_939 1165-0479 45.3 µM -1.68572440892463 0.0452773412478509 no 3197 0.0459244466052362 1020 1377347
SGTC_2809 7964133 12.99 µM -1.69064650388004 0.0448110135264651 no 3198 0.0454521686079731 1053 1253665
SGTC_176 1486-1328 72.834 µM -1.69753508325599 0.0441648793695413 no 3199 0.044797772058823 1023 22310231
SGTC_1105 epirubicin 18.1 µM -1.70818196158708 0.0431810206624191 no 3200 0.0438012922478881 1041 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3034 9090421 49.47 µM -1.71206912988539 0.0428262561154036 no 3201 0.0434419647528785 1038 17173761
SGTC_3199 9111318 49.47 µM -1.71842616305592 0.0422511576118257 no 3202 0.0428594557986324 1032 8548020
SGTC_3176 9106582 49.47 µM -1.72367433544922 0.0417810966845724 no 3203 0.0423833253265606 1052 17018027
SGTC_2424 5537928 59.2 µM -1.72419353478741 0.0417348248902707 no 3204 0.0423364554455445 1021 5382802
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.72860074373554 0.0413437173437627 no 3205 0.0419402882215758 1054 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2125 5246583 200 µM -1.73138158995876 0.0410984698523924 no 3206 0.0416918639772017 1057 835267
SGTC_1338 1486-1223 76 µM -1.73840070991396 0.0404846859405541 no 3207 0.0410701158514202 1038 3444526
SGTC_1171 0368-0077 21.4 µM -1.74214130238551 0.0401606436588685 no 3208 0.0407418609796463 1051 3239779
SGTC_2289 7946404 165.07 µM -1.74226908094856 0.0401496117072298 no 3209 0.0407306855141711 1029 1246120 YPR165W RHO1
SGTC_1232 0279-0259 161 µM -1.74301133075122 0.0400855771476014 no 3210 0.0406658178072474 1043 1560000
SGTC_2150 5556613 200 µM -1.7444994474224 0.0399574459314787 no 3211 0.0405360188401002 1046 743190
SGTC_1343 1487-0095 224 µM -1.74515477596355 0.0399011258817576 no 3212 0.0404789654568414 1042 4560101 YGL055W OLE1
SGTC_280 3448-3607 3.04 µM -1.74660430747398 0.0397767798629844 no 3213 0.0403529997570568 1027 626179
SGTC_2004 4023728 41.89 µM -1.74736345630153 0.0397117831575728 no 3214 0.0402871561054814 1028 360084 YDR527W RBA50
SGTC_97 0535-0701 19.132 µM -1.74935131553469 0.0395419959323415 no 3215 0.0401151553950135 1007 2832013 YGL099W LSG1
SGTC_2763 lisinopril 49.32 µM -1.75473483725807 0.0390851411733344 no 3216 0.0396523370981188 1025 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3287 9117173 37.0625 µM -1.75982562060396 0.0386570905390938 no 3217 0.0392186888068703 1001 2789709
SGTC_1306 1185-0270 9.02 µM -1.76225350249076 0.0384542952009109 no 3218 0.0390132380624027 1050 1548076
SGTC_3261 9137475 49.47 µM -1.76225385711333 0.038454265643572 no 3219 0.0390132081178781 1037 17027690
SGTC_2119 5528445 120.635 µM -1.76415292357777 0.0382962462506487 no 3220 0.0388531180796729 1060 791935
SGTC_19 0279-0214 38.434 µM -1.76474804691598 0.0382468357354837 no 3221 0.0388030598252493 1060 3566274 YBR002C RER2
SGTC_2845 9003024 42.97 µM -1.76558892511935 0.0381771098852068 no 3222 0.0387324196905584 1039 2990173
SGTC_3327 9140648 26.9345 µM -1.76849035616496 0.0379373179963734 no 3223 0.0384894815066601 1034 8029710
SGTC_2107 5363541 170.161 µM -1.77390821457687 0.0374928435540283 no 3224 0.0380391668768665 1043 244052
SGTC_2611 pyromycin 23.93 µM -1.77625668750288 0.0373015034302715 no 3225 0.0378453093126583 1057 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3081 9117243 49.47 µM -1.77731282298353 0.0372157159818545 no 3226 0.0377583925172936 1054 45595589
SGTC_1678 st019265 80.2 µM -1.78130206248385 0.0368931325991659 no 3227 0.0374315588739804 1042 5367020
SGTC_3164 9100705 49.47 µM -1.78137945044631 0.0368868974239484 no 3228 0.0374252414895492 1035 17174235
SGTC_821 1114-0266 29.2 µM -1.7883699903904 0.0363272113299035 no 3229 0.0368581673169612 1051 3123235
SGTC_1167 k781-0610 148 µM -1.78884693114265 0.0362892805370722 no 3230 0.0368197351938691 1032 4525169
SGTC_167 3672-0051 66.205 µM -1.78956425607737 0.0362322931985216 no 3231 0.0367619945046752 1034 3237971
SGTC_1106 tegaserod maleate 11.7 µM -1.79077174847854 0.036136530354762 no 3232 0.0366649653055589 1041 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_822 1487-0950 154 µM -1.79371820417743 0.035903724873714 no 3233 0.036429079100115 1038 1958375
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.79682282235068 0.0356597535127933 no 3234 0.0361818759998816 1050 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2028 5153890 36.43 µM -1.80105450168906 0.0353294038016733 no 3235 0.0358471450145438 1063 2830968 YPR165W RHO1
SGTC_90 0870-0863 4.608 µM -1.80617438735589 0.0349330754012417 no 3236 0.0354455521573181 1048 1738164
SGTC_1767 st044992 70.3 µM -1.80633459685659 0.0349207327715289 no 3237 0.0354330454365386 1051 9600693
SGTC_2960 9079389 5.97 µM -1.80809653496863 0.034785228091509 no 3238 0.0352957386978984 1041 16457355
SGTC_1358 1509-0022 2.48 µM -1.81240881580177 0.0344554058705879 no 3239 0.034961525837871 1055 3258434
SGTC_946 3434-1334 87.4 µM -1.81359402212944 0.0343652075765287 no 3240 0.0348701257278078 1034 4047976
SGTC_1972 st070201 17.4 µM -1.82220819295373 0.0337154540569684 no 3241 0.0342117009574413 1053 2829099
SGTC_2263 7948595 193.29 µM -1.82585938001403 0.0334431178825831 no 3242 0.0339357230690445 1047 2971371
SGTC_2954 9074818 52.69 µM -1.83240981417665 0.0329590717060763 no 3243 0.0334451934884369 1062 16648742
SGTC_3230 9131665 49.47 µM -1.83734879594148 0.0325979346446816 no 3244 0.0330792103330641 1036 15943720
SGTC_2369 9071472 200 µM -1.84602558217842 0.0319713956495245 no 3245 0.0324442455050236 1049 17296037
SGTC_1938 st074717 56.4 µM -1.85089198898262 0.0316243737848428 no 3246 0.0320925467386829 1022 17250979
SGTC_1335 1486-0900 202 µM -1.86506649429494 0.0306312933600565 no 3247 0.0310860421618202 1049 X1335
SGTC_1846 st056244 14.8 µM -1.86638532307501 0.0305402227898234 no 3248 0.0309937375230939 1056 5393182
SGTC_3159 9100096 49.47 µM -1.86972599704574 0.0303105386407408 no 3249 0.0307609387365976 1064 25236875
SGTC_3348 9149464 3.537 µM -1.87733725479136 0.02979257828229 no 3250 0.030235942622094 1053 1951442
SGTC_1313 1220-0047 237 µM -1.88067018981648 0.0295680888013417 no 3251 0.0300083985990391 1048 3528706
SGTC_2737 bleomycin 30.5 nM -1.88625527463936 0.0291950544730392 no 3252 0.0296302815713034 1059 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.89854440854399 0.0283880010599867 no 3253 0.0288122017955215 1041 88881 An O-methylated flavonoid and antioxidant.
SGTC_2557 derrustone 83.84 µM -1.93106665689107 0.0263413545957704 no 3254 0.0267374048820285 1053 629853 An antioxidant.
SGTC_1935 st074532 41.6 µM -1.93461732783548 0.0261255698057493 no 3255 0.0265186360341462 1051 2829742
SGTC_249 wiskostatin 11.211 µM -1.93836611904163 0.025899350934087 no 3256 0.0262892854652332 1051 2775510 A n-wasp and actin depolymerizer.
SGTC_439 amiodarone 34.4 µM -1.93950199510528 0.0258311314647366 no 3257 0.0262201209136697 1052 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3355 9151058 44.0485 µM -1.94625333449627 0.0254287494319765 no 3258 0.0258121580626293 1080 17015728
SGTC_592 k241-0073 46.5 µM -1.95124702563744 0.0251345129299353 no 3259 0.0255138336986068 1072 4230158
SGTC_2803 7707263 71.43 µM -1.96346717739259 0.0244264974943264 no 3260 0.0247959573606969 1052 2199229
SGTC_2116 5511452 16.8835 µM -1.98030079660074 0.0234786654588799 no 3261 0.0238348696751988 1065 870744
SGTC_2995 9067767 71.4286 µM -1.98166473647013 0.0234032415667275 no 3262 0.0237583882360249 1054 11673567
SGTC_290 2043-6722 48.1 µM -1.98973721018828 0.0229610079488803 no 3263 0.0233099457097364 1066 773758 YLR208W SEC13
SGTC_1305 1181-0477 144 µM -1.99017985404899 0.0229369635810013 no 3264 0.0232855633592034 1071 6252086
SGTC_1355 1499-0035 1.68 µM -1.99623572424663 0.0226101338044639 no 3265 0.0229541353148204 1065 1548538
SGTC_1837 st055472 66.5 µM -2.00396347223547 0.0221987836662032 no 3266 0.0225369867218895 1065 676091
SGTC_2708 st078559 56 µM -2.01272140535143 0.0217402482865098 no 3267 0.0220719731016617 1046 17250902
SGTC_1913 st060213 96.1 µM -2.01291167386022 0.0217303759535271 no 3268 0.0220619611200292 1060 688959
SGTC_2176 5809774 33.9695 µM -2.02088064905974 0.0213202829746704 no 3269 0.0216460607640695 1044 2870539
SGTC_631 k072-0230 41.5 µM -2.02844829627354 0.0209369200760351 no 3270 0.0212572575874056 1069 5773147
SGTC_2032 5185112 25.99 µM -2.03895670120993 0.0204142719156974 no 3271 0.0207271745572947 1063 5718189
SGTC_1151 3909-8316 15.3 µM -2.0575935147485 0.0195145308586852 no 3272 0.019814584861642 1067 800431
SGTC_270 tamoxifen 5.46 µM -2.05831473397191 0.0194804000098056 no 3273 0.0197799653621082 1084 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_654 1124-0271 80.9 µM -2.08676209918336 0.0181740304442574 no 3274 0.0184548223625812 1079 5403748
SGTC_1240 0356-0016 42.1 µM -2.08865935915641 0.0180896246723772 no 3275 0.0183691988494937 1015 4305613
SGTC_1491 4138-0063 26.5 µM -2.09031530914861 0.0180162276942969 no 3276 0.0182947424786093 1081 23883227
SGTC_3071 9117417 49.47 µM -2.09313665387262 0.0178917615106994 no 3277 0.0181684787633252 1066 45595590 YGL055W OLE1
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.10473318754944 0.017387843442315 no 3278 0.0176572699417024 1063 23665772 A membrane-active detergent.
SGTC_865 0488-0499 301 µM -2.10495908101839 0.0173781490206287 no 3279 0.0176474350507765 1067 9634651
SGTC_2220 6782180 200 µM -2.11389661827247 0.0169982735954291 no 3280 0.0172620490708986 1066 833803
SGTC_2814 7977482 42.97 µM -2.11643330320591 0.0168917579468261 no 3281 0.0171539860746262 1069 6456762
SGTC_2555 cholic acid 100 µM -2.11762057293965 0.0168421007811785 no 3282 0.0171036072091311 1066 6708657 Influences liver metabolism.
SGTC_1079 idarubicin 2.36 µM -2.11823958800846 0.0168162602307745 no 3283 0.0170773910173777 1074 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1579 chlormadinone acetate 49.4 µM -2.11933478962527 0.0167706245201781 no 3284 0.0170310917649044 1066 45114258 A steroidal progestin.
SGTC_3183 9108214 49.47 µM -2.12385714569476 0.0165833036691705 no 3285 0.0168410453907904 1082 4974831
SGTC_1739 st037196 92.5 µM -2.12922646726117 0.0163632283382308 no 3286 0.0166177640683071 1065 612214
SGTC_61 0978-8327 98.565 µM -2.12964284707281 0.0163462669315485 no 3287 0.0166005553976421 1056 6150059 YHR072W ERG7
SGTC_2856 9022925 19.48 µM -2.13059752474485 0.016307434562104 no 3288 0.0165611568337874 1064 4944862
SGTC_1285 0929-0069 65.5 µM -2.13298761084643 0.0162105620174866 no 3289 0.016462871265399 1077 1206237
SGTC_1886 st057356 49.9 µM -2.14293227762014 0.0158127701416939 no 3290 0.0160592683534704 1073 24207747
SGTC_2463 5473429 200 µM -2.14434398584234 0.0157569852597067 no 3291 0.0160026674300101 1071 5399405
SGTC_697 0508-1955 564 µM -2.15289477142682 0.01542268864011 no 3292 0.0156634747558107 1069 6243113
SGTC_446 go6976 132 µM -2.16524254545426 0.0149507016268474 no 3293 0.0151845578648808 1083 3501 A protein kinase C inhibitor.
SGTC_2829 7992743 58.44 µM -2.17223390467666 0.0146890071386555 no 3294 0.0149190122765028 1068 16462845
SGTC_337 1315-0038 354 µM -2.17763135998421 0.0144896788782155 no 3295 0.014716746430913 1076 1626437
SGTC_2212 7123476 200 µM -2.19009572970936 0.014038246637772 no 3296 0.0142586474363573 1082 1085715
SGTC_2994 9053520 71.4286 µM -2.19134598956667 0.0139936411782992 no 3297 0.0142133821937619 1070 4647384
SGTC_1483 3453-0561 55.9 µM -2.19427343939946 0.0138896763805831 no 3298 0.0141078788587892 1079 4546991
SGTC_2476 5806916 10.51 µM -2.20025369627384 0.0136793632971385 no 3299 0.0138944502526364 1058 2870194
SGTC_2819 7996655 46.38 µM -2.20242448405442 0.0136037038704045 no 3300 0.0138176689818717 1063 6456960
SGTC_3342 9147791 14.508 µM -2.2040109205464 0.0135486397473831 no 3301 0.013761788043378 1072 1838168
SGTC_2711 st079103 59.1 µM -2.20420155107404 0.0135420360575203 no 3302 0.0137550863752637 1075 54693780
SGTC_2402 5553605 200 µM -2.23378596800714 0.0125502925804803 no 3303 0.0127485796278867 1078 6758546
SGTC_740 k014-0057 261 µM -2.25248940001565 0.0119562839875692 no 3304 0.0121456809149348 1078 4012779
SGTC_670 4204-0025 119 µM -2.2541038584895 0.011906172231576 no 3305 0.0120948174986032 1076 719039
SGTC_492 tmb-8 126 µM -2.25608999462991 0.0118447738543821 no 3306 0.0120324978067774 1087 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3086 9117350 49.47 µM -2.25695045072772 0.0118182595643985 no 3307 0.0120055855337131 1079 2679265
SGTC_935 2996-0153 430 µM -2.25989208841713 0.0117280038675133 no 3308 0.01191397453184 1079 23738523
SGTC_2012 4023501 200 µM -2.26026548948049 0.011716590028515 no 3309 0.0119023892382084 1076 3477460
SGTC_1705 st027868 56.3335 µM -2.26543429117281 0.0115595817278456 no 3310 0.0117430210139991 1066 292948
SGTC_1284 0929-0043 16 µM -2.26578201012642 0.0115490852642673 no 3311 0.0117323666892402 1076 1239883
SGTC_199 4063-0024 41.6 µM -2.26608313158831 0.0115400021104756 no 3312 0.0117231469202145 1088 306215
SGTC_2983 9022671 12.99 µM -2.29484415605153 0.0107005480492308 no 3313 0.0108710285494951 1079 6405161
SGTC_3354 9151612 71.43 µM -2.29794330760648 0.0106133474735947 no 3314 0.0107825079973857 1071 27261949
SGTC_3216 9129716 49.47 µM -2.30780213373935 0.0103400540123476 no 3315 0.0105050721024403 1060 8056934
SGTC_1445 4239-0156 97.7 µM -2.3139917665614 0.0101716259505201 no 3316 0.0103340868885895 1084 4008346
SGTC_2505 galangin 7.89 µM -2.31822000465491 0.0100579504510602 no 3317 0.0102186836820372 1082 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2187 6125751 200 µM -2.31921023993331 0.0100314889173093 no 3318 0.0101918197570971 1086 874498
SGTC_2423 st077119 87.2 µM -2.34025544370135 0.00948330084854357 no 3319 0.00963527723438942 1072 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3058 9093861 49.47 µM -2.34103761671445 0.00946344166945056 no 3320 0.00961511473422269 1074 17217477
SGTC_797 k781-0471 270 µM -2.34911024140152 0.0092605949705828 no 3321 0.00940916713454763 1064 23738129
SGTC_3096 9117468 49.47 µM -2.37726492845727 0.00858260661337963 no 3322 0.0087207780402547 1078 41316311
SGTC_3128 9127691 49.47 µM -2.37976551174726 0.00852455076149441 no 3323 0.00866182892292228 1078 41316314
SGTC_2201 6605497 169.863 µM -2.38146092945397 0.0084853846603345 no 3324 0.00862205995940978 1087 670741
SGTC_2123 5259487 200 µM -2.39521860832235 0.00817336371539209 no 3325 0.00830522926326619 1081 2173474
SGTC_3093 9117344 49.47 µM -2.40510083320802 0.00795550221632547 no 3326 0.00808400201358503 1075 24824913
SGTC_2617 dihydrotanshinone i 20.83 µM -2.43197253925656 0.00738870895309421 no 3327 0.00750842289351549 1073 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1176 0848-0131 83.3 µM -2.45276794145565 0.00697481738429935 no 3328 0.00708808792955636 1087 6769040
SGTC_1332 1480-0653 17.5 µM -2.45524372709347 0.0069269313555188 no 3329 0.00703945487249362 1078 5749438
SGTC_608 k048-0125 159 µM -2.45665546315968 0.00689975606231641 no 3330 0.00701185549669796 1084 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2796 7949634 45.45 µM -2.52242893062702 0.0057335762468725 no 3331 0.00582737490335025 1076 2971588
SGTC_668 1682-0499 62.6 µM -2.54309221989684 0.00540520334906836 no 3332 0.00549381126402528 1083 682214
SGTC_3177 9107506 49.47 µM -2.5486092927429 0.00532040495851266 no 3333 0.00540766960846032 1091 8897194
SGTC_2025 5147754 141 µM -2.54863877564697 0.0053199549971548 no 3334 0.00540721251627714 1072 315777 YLR208W SEC13
SGTC_2199 6590217 200 µM -2.56599507569823 0.00506086837396213 no 3335 0.00514401443611767 1075 703109
SGTC_1251 0490-5699 265 µM -2.59196546327261 0.00469416014659215 no 3336 0.00477146755673964 1078 3883818
SGTC_2269 7935389 174.42 µM -2.60505679000364 0.00451845012581193 no 3337 0.00459295164951204 1078 97605
SGTC_3126 9127922 49.47 µM -2.61555242849356 0.00438184586989687 no 3338 0.00445416218482567 1064 45595682
SGTC_431 k089-0097 107 µM -2.62055680240915 0.0043180210378363 no 3339 0.00438931521505152 1044 5499420
SGTC_2859 9028643 45.46 µM -2.64765509246032 0.00398663358064079 no 3340 0.00405260859517891 1074 17151580
SGTC_2808 7946468 45.46 µM -2.66369094263072 0.00380143343978679 no 3341 0.00386442673096412 1078 2970879
SGTC_2707 st078556 66.6 µM -2.67747605256386 0.00364843280686501 no 3342 0.00370895775381167 1079 17250899
SGTC_1017 4239-0030 168 µM -2.76440605444231 0.00280450292640321 no 3343 0.00285132628355167 1085 1149593
SGTC_1246 0422-0085 105 µM -2.77375213708652 0.00272516668678518 no 3344 0.00277069402649861 1083 264295
SGTC_1346 1488-2224 62.4 µM -2.83324541403354 0.00226590384593566 no 3345 0.00230389976585794 1089 3722427
SGTC_3095 9117207 49.47 µM -2.96393020560346 0.0014934784693492 no 3346 0.00151868584190415 1090 17015229
SGTC_45 0kpi-0036 14.9 µM -3.01019913090615 0.00128367769363062 no 3347 0.00130538231255682 1084 2795021
SGTC_3125 9127534 49.47 µM -3.38898920285469 0.000344900079036994 yes 3348 0.000350753863424485 1088 1639235
SGTC_2543 pimpinellin 60.67 µM -3.48868056430772 0.000238663620214953 yes 3349 0.000242705426188701 1093 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2914 7968218 45.32 µM -3.52417404011306 0.000208869251301366 yes 3350 0.000212402562719036 1093 2977111
SGTC_2008 4012253 172 µM -3.5329659592125 0.000202045836009548 yes 3351 0.000205462689406636 1090 603940
SGTC_1169 aniline yellow 25.8 µM -3.64393412626955 0.000132028836688467 yes 3352 0.000134251083580981 1090 6051 A DNA damaging agent.
SGTC_3090 9117696 49.47 µM -3.81470813447252 6.70553301407637e-05 yes 3353 6.81719906846641e-05 1094 7923821
SGTC_42 0133-0086 60.653 µM -5.8340981043524 2.67930738101261e-09 yes 3354 2.70411477062921e-09 1095 162923 Model of phenazepam hydroxylation.
SGTC_41 0478-0632 82.643 µM -8.45202295918079 1.4531892466413e-17 yes 3355 1.43149139986136e-17 1095 3750424
SGTC_38 0929-0051 58.268 µM -8.91723119827983 2.44150577200792e-19 yes 3356 2.39045453181678e-19 1095 1379719