SGTCid condition conc unit PHO85|YPL031C.score PHO85|YPL031C.strain.pval PHO85|YPL031C.strain.significant PHO85|YPL031C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2988 9073640 71.4286 µM 5.27468847414529 6.3735395426441e-07 yes 1 6.64908942781429e-08 10 9102229 SGTC_1047 2043-3044 82 µM 5.27158193768892 6.46720753224382e-07 yes 2 6.76264404905858e-08 12 669592 SGTC_1484 3473-2379 286 µM 4.85809836968253 4.19449126204456e-06 yes 3 5.92592635130101e-07 5 671917 SGTC_1386 3228-0095 33.8 µM 4.77493421781959 6.00455340055155e-06 yes 4 8.98830032172755e-07 8 870181 SGTC_1455 4262-0120 131 µM 4.3956056842863 2.86653779328251e-05 yes 5 5.52321511227848e-06 20 1529587 SGTC_1665 st014639 11.4 µM 4.35343791229075 3.38543790706411e-05 yes 6 6.70095318606317e-06 16 981133 YIL048W NEO1 SGTC_2767 sibutramine 71.45 µM 4.31623682497969 3.91588077336527e-05 yes 7 7.93558503076879e-06 15 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_86 0417-1630 471.922 µM 4.3053683247748 4.08511133039176e-05 yes 8 8.33540639576171e-06 132 3634867 SGTC_1253 0550-0034 176 µM 4.22397092009337 5.59067786971706e-05 yes 9 1.20017517825926e-05 16 5969915 SGTC_2146 5545642 200 µM 4.18158081548196 6.56875452524333e-05 yes 10 1.44744659155291e-05 11 825326 SGTC_1382 3002-2117 298 µM 4.05784334995483 0.000104274842141147 yes 11 2.47639850188408e-05 10 1497314 SGTC_134 0269-0018 6.916 µM 4.01368183349311 0.00012259669336636 yes 12 2.98894561951066e-05 130 4378915 SGTC_1660 st012960 28.1 µM 3.8941479750014 0.000188478192717066 yes 13 4.92722417843196e-05 38 24207266 SGTC_165 k038-0023 64.381 µM 3.85479454132396 0.000216589664116542 yes 14 5.79134302186588e-05 83 46368543 SGTC_1025 k007-0731 70 µM 3.85340640923811 0.000217649329131393 yes 15 5.82429007516801e-05 15 6256118 SGTC_1755 st041960 45.185 µM 3.84014172280664 0.000228022215049921 yes 16 6.14816521644045e-05 29 2257073 SGTC_2409 alverine citrate 63.97 µM 3.7817990750024 0.000279361430693371 yes 17 7.78495069459134e-05 57 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3013 9080133 71.4286 µM 3.70169421442038 0.000367516693977851 yes 18 0.000107082315910031 26 17050193 SGTC_200 k038-0079 37.545 µM 3.68021858249008 0.000395204744097233 yes 19 0.000116517055998075 61 3436683 SGTC_1668 st014914 51.6 µM 3.67118683381619 0.000407417568385769 yes 20 0.000120713384884872 4 2839556 SGTC_984 1492-0255 2.91 µM 3.57225324657742 0.000566148443693921 yes 21 0.000176961453772173 38 1585198 SGTC_142 0335-0849 62.6745 µM 3.42917859563943 0.000898350197297904 yes 22 0.000302705503029137 159 3889043 YPR107C YTH1 SGTC_1901 st060216 58.6 µM 3.39443256967976 0.00100242187124253 no 23 0.000343854865887122 41 688792 SGTC_2561 acetosyringone 100 µM 3.37245391543791 0.00107384943579272 no 24 0.000372507765632847 51 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2105 5350118 200 µM 3.34258842913243 0.0011783937737024 no 25 0.00041500452342584 49 2133313 SGTC_121 0557-0495 61.343 µM 3.3302150559188 0.00122437487584108 no 26 0.000433894660239872 98 3104427 SGTC_2755 lomerizine 42.69 µM 3.31898614496534 0.00126751807487111 no 27 0.00045172455931179 47 3949 A calcium channel blocker. SGTC_2049 5262831 67.185 µM 3.30598706816667 0.00131919645707217 no 28 0.000473212277778376 57 763417 SGTC_832 4083-0019 164 µM 3.2976025073249 0.00135354394309363 no 29 0.000487570365094124 150 1990758 SGTC_2357 9067248 200 µM 3.24515479340978 0.00158759262376527 no 30 0.000586933973617823 49 9150235 SGTC_2137 5261020 140 µM 3.21795079001772 0.00172300608030457 no 31 0.000645549834326729 63 763655 SGTC_2144 5628481 200 µM 3.18596453555644 0.00189562258004823 no 32 0.000721361406967426 56 2818399 SGTC_1471 k673-0312 37 µM 3.15773667862217 0.00206085429158434 no 33 0.000794995542831741 29 24099884 SGTC_1468 k284-1086 134 µM 3.12897532756651 0.00224254972166486 no 34 0.000877085183952299 92 15996457 SGTC_927 2425-1185 123 µM 3.11336008306932 0.00234716450291019 no 35 0.000924850954382558 60 730375 SGTC_2162 5663267 200 µM 3.10913428550319 0.00237622498061028 no 36 0.000938182081682439 35 6456493 SGTC_1932 st074806 40.9 µM 3.07104457240801 0.00265323275048941 no 37 0.00106655652563596 70 17251235 SGTC_1402 3909-7673 35.9 µM 3.0488938481784 0.00282742709047083 no 38 0.0011484281222616 41 5328014 SGTC_1024 4507-0395 26 µM 3.04581152230919 0.00285246750845911 no 39 0.00116026624774492 65 4201836 SGTC_1181 1222-0449 220 µM 3.03355479943016 0.00295403042572637 no 40 0.00120845405629811 63 658318 SGTC_2618 avocadyne 43.43 µM 3.03097706585476 0.00297580068054476 no 41 0.00121881881250852 62 3015189 SGTC_770 0389-1121 67.2 µM 3.02254897656544 0.00304799292532653 no 42 0.00125327759148781 67 6753108 SGTC_2251 lansoprazole 556 µM 2.92904458540572 0.00396142130292246 no 43 0.00170002824111558 46 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_621 3584-0052 32.1 µM 2.92088698542798 0.00405171203154499 no 44 0.00174518207892048 69 2273927 SGTC_2457 5731572 11.68 µM 2.90796128429576 0.00419855335055146 no 45 0.00181896686493762 44 2865357 SGTC_2566 crystal violet carbinol 226 nM 2.9016901730798 0.00427149618283247 no 46 0.00185577711140861 94 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2927 9011802 47.9 µM 2.8744256350187 0.00460196777141356 no 47 0.00202381538181089 85 43912568 SGTC_1334 1486-0610 236 µM 2.86809337726786 0.00468191230022899 no 48 0.00206476817919493 73 3742339 SGTC_2157 5649910 96.377 µM 2.84380867537012 0.00500011449920615 no 49 0.00222889034373882 85 2858091 SGTC_1454 4239-0054 42.6 µM 2.83820730506745 0.00507618845941039 no 50 0.00226838534267197 90 1340767 SGTC_7 0192-1582 4.227 µM 2.81023317055935 0.00547174916305032 no 51 0.00247528098747014 150 252616 SGTC_1896 st058441 89 µM 2.79847864179036 0.0056459758600073 no 52 0.00256719824825398 64 688759 SGTC_83 0170-0301 39.027 µM 2.78516791324086 0.00584920097718191 no 53 0.00267500051264596 20 3089716 SGTC_556 4058-0063 51.5 µM 2.76365862942529 0.0061913343281173 no 54 0.00285786511332864 86 6615692 SGTC_2460 5552655 174.22 µM 2.75715774181291 0.00629817059324756 no 55 0.00291531083036251 100 5401989 SGTC_1627 st003713 25.6 µM 2.73335194282872 0.00670345966691009 no 56 0.00313466512649219 204 16195070 YER133W GLC7 SGTC_776 4476-4378 112 µM 2.71464586393948 0.00703792637614989 no 57 0.00331733378092415 83 2892008 SGTC_1908 st060353 56.5 µM 2.71137629438179 0.00709787517098689 no 58 0.00335022689586391 117 4227716 SGTC_2403 6032726 181.2 µM 2.69681521160159 0.00737036347824243 no 59 0.00350030532140599 111 2881040 SGTC_467 ro 31-8220 72.8 µM 2.69171471454109 0.00746796900474071 no 60 0.00355428618913923 168 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1489 4065-0444 182 µM 2.68719995733303 0.00755531382193414 no 61 0.00360269021888938 83 2877968 SGTC_1231 0242-0792 125 µM 2.68055313850803 0.00768554387488055 no 62 0.00367502968676468 92 3707635 SGTC_1836 st055642 81 µM 2.66941139292502 0.00790827783049541 no 63 0.00379921593502077 108 8571 SGTC_895 0964-0006 13.7 µM 2.66794437854246 0.00793802378363841 no 64 0.00381584456270003 75 6738897 SGTC_16 erodoxin 22.806 µM 2.66508404281957 0.00799630450973166 no 65 0.00384845423088319 146 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_740 k014-0057 261 µM 2.6548020979712 0.00820892244134338 no 66 0.0039677474355697 106 4012779 SGTC_502 l-744,832 89.3 µM 2.63447057321661 0.00864401717173756 no 67 0.00421343039790151 120 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1460 k062-0059 9.15 µM 2.62816343771527 0.0087830388416331 no 68 0.00429236293955583 87 1373085 SGTC_3341 9147222 25.867 µM 2.61081788816524 0.00917552408898321 no 69 0.0045162989904349 79 1939759 SGTC_3145 9085516 49.47 µM 2.58824113595192 0.00970932030265711 no 70 0.00482337118747955 111 25236195 SGTC_3220 9131269 49.47 µM 2.58437235188203 0.00980346570086132 no 71 0.00487782044812605 59 17722206 SGTC_429 1112-0049 25.5 µM 2.58351512079673 0.00982443368013548 no 72 0.00488995900070437 132 2836170 SGTC_2343 7990716 14.84 µM 2.56879526642647 0.0101906427221144 no 73 0.00510263652781701 95 6456862 SGTC_2177 5811945 192 µM 2.56430095688502 0.0103048021409713 no 74 0.00516919287357444 101 5343475 SGTC_23 0213-0011 39.996 µM 2.56358387642993 0.0103231193932238 no 75 0.00517988330704386 100 627608 SGTC_331 k048-0133 24.5 µM 2.56006553540498 0.0104134045647005 no 76 0.00523262130828662 77 6813582 SGTC_1933 st074711 15.9 µM 2.55496424700013 0.0105455323898278 no 77 0.00530993527959161 151 17250958 SGTC_1925 st057770 10.1 µM 2.55373949751451 0.0105774710618685 no 78 0.00532864787164274 95 5989122 SGTC_3074 9116018 49.47 µM 2.54242467616462 0.0108765430792533 no 79 0.00550431631524809 86 17027303 SGTC_763 3453-1109 128 µM 2.5423939529481 0.0108773650686479 no 80 0.00550480023195161 106 1560353 SGTC_1478 0453-0656 35.7 µM 2.53988803243451 0.01094459243688 no 81 0.00554439811026486 85 5258496 SGTC_2512 diallyl trisulfide 49.23 µM 2.5396540718242 0.0109508874085492 no 82 0.00554810797623675 59 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1055 3448-0672 86 µM 2.53593490206675 0.0110513797293394 no 83 0.0056073789622854 129 748378 SGTC_583 1488-1091 88.9 µM 2.52058733610177 0.0114746039346218 no 84 0.00585795800600976 116 4303273 SGTC_997 3996-0078 137 µM 2.4759125910817 0.0127876396169637 no 85 0.00664480548922231 143 735687 SGTC_2762 leflunomide 42.06 µM 2.46418166475422 0.013153256705982 no 86 0.00686632445681016 136 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2351 9026858 72.31 µM 2.4615145434945 0.0132376319580033 no 87 0.0069175894213334 128 1409300 SGTC_1056 3448-1962 115 µM 2.45833739365827 0.0133387520466296 no 88 0.00697909854412235 107 715507 SGTC_1307 1187-1599 12.2 µM 2.44089174413618 0.0139059698436623 no 89 0.00732552297304424 112 1538471 SGTC_1852 st056254 31.4 µM 2.43594446604075 0.014070560415864 no 90 0.00742648231770257 103 442583 SGTC_2850 9015429 58.44 µM 2.4286380355794 0.014316707030545 no 91 0.00757782734234783 123 6457570 SGTC_46 0329-0187a 2.197 µM 2.4234411742776 0.0144940331658713 no 92 0.00768712150737642 214 46494817 SGTC_1892 st058411 7.36 µM 2.4195196438741 0.0146290913048285 no 93 0.00777051065388314 141 3934738 SGTC_642 0335-0876 158 µM 2.41492909610585 0.014788564950809 no 94 0.00786913651665489 144 6812350 SGTC_5 0352-0601 109.883 µM 2.40035844586969 0.0153046852716747 no 95 0.00818951214968169 85 762456 SGTC_1239 0337-0584 35.4 µM 2.38879972834871 0.015725049293743 no 96 0.00845175697432994 198 914301 YML130C ERO1 SGTC_3338 9144300 39.5675 µM 2.38179594230796 0.0159845495666787 no 97 0.00861422062929194 133 4901274 SGTC_309 k408-0051 1.48 µM 2.38157901956228 0.0159926451278138 no 98 0.0086192959267061 215 3640463 SGTC_2428 5615643 7.78 µM 2.37410281816359 0.0162738130088253 no 99 0.00879582554928533 129 2253075 SGTC_1848 st056003 16.4 µM 2.37321909988462 0.0163073263915734 no 100 0.00881690011224517 131 146492 SGTC_162 k030-0015 37.8 µM 2.37277999823554 0.0163240004803982 no 101 0.00882738808351613 119 1809920 YMR134W ERG29 SGTC_55 0767-0285 6.563 µM 2.36780279982899 0.0165140235621887 no 102 0.00894703535600004 160 3116166 SGTC_1814 st052110 31.539 µM 2.35418274962803 0.0170437268960958 no 103 0.00928174105895261 105 674163 SGTC_2050 5263056 171 µM 2.34980817170545 0.0172169131920179 no 104 0.00939154419346994 180 763468 YGL055W OLE1 SGTC_1911 st060208 74.3 µM 2.34907278835414 0.0172461736014497 no 105 0.00941011365194566 151 688783 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.34847657472943 0.0172699277157719 no 106 0.00942519244487538 187 688664 SGTC_2342 7990637 118.86 µM 2.33578602288942 0.0177822084085617 no 107 0.00975119822185656 160 2033102 YER133W GLC7 SGTC_2912 7964298 10.93 µM 2.33426404156398 0.0178445083212446 no 108 0.00979095018450017 240 2975850 SGTC_1228 0124-0032 52.5 µM 2.32748869688835 0.0181241104166284 no 109 0.00996963494533387 152 X1228 SGTC_54 0159-0055 9 µM 2.31506919714871 0.0186463344381155 no 110 0.0103045727211101 146 3319099 SGTC_833 3852-0053 558 µM 2.30510740898312 0.0190744214537917 no 111 0.0105802793282688 154 3123681 SGTC_2475 5812728 15.03 µM 2.28679117104729 0.0198833475314767 no 112 0.0111040075378363 158 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1902 st060212 70.5 µM 2.28508887971028 0.0199599854419411 no 113 0.011153808362579 139 688944 SGTC_2229 7354935 190 µM 2.2836140905262 0.020026583578398 no 114 0.0111971104710285 82 318112 SGTC_1116 jasmonic acid  1.58368 µM 2.28207411636307 0.0200963264038165 no 115 0.0112424824268363 149 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1326 1431-2094 10.8 µM 2.2700539523751 0.0206478107751456 no 116 0.0116021548711243 173 616278 SGTC_1369 1866-0067 208 µM 2.24389043868505 0.0218926236238554 no 117 0.012419725743409 200 3531355 SGTC_704 1310-0270 142 µM 2.24149732172906 0.0220095827813781 no 118 0.0124969394099539 185 5718033 SGTC_893 0958-0369 48.9 µM 2.24037286486985 0.0220647204262085 no 119 0.0125333631965352 191 6819948 SGTC_2017 5132927 60.65 µM 2.23859233040132 0.0221522672451029 no 120 0.0125912268653533 181 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_669 0108-0021 26.2 µM 2.22456922064073 0.0228520662420374 no 121 0.0130550854088556 285 17201 SGTC_1651 st011928 86.1 µM 2.21142552141227 0.0235247998618719 no 122 0.0135031920702351 142 720198 SGTC_892 0929-0076 29 µM 2.20245816381591 0.0239932736247423 no 123 0.0138164806094214 230 5751038 SGTC_2790 5423970 71.43 µM 2.19763281077473 0.0242485880545075 no 124 0.0139876415521815 231 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_998 3996-0085 177 µM 2.1961140042766 0.0243294202660936 no 125 0.0140418922338155 176 715391 SGTC_36 0335-0881 14.2 µM 2.19187611720525 0.0245561615603512 no 126 0.0141942265035265 286 23828853 SGTC_2694 st077685 81.9 µM 2.17847330775109 0.0252849615432624 no 127 0.0146854086768561 196 2838096 SGTC_2160 5660466 132.927 µM 2.17200063148183 0.0256433622231122 no 128 0.0149278076429157 162 2859134 SGTC_2695 st077686 51.995 µM 2.16383982429818 0.0261012889195589 no 129 0.0152383222795221 189 2876092 SGTC_1849 st056239 19.2 µM 2.15702259805037 0.0264890476234591 no 130 0.0155019518614331 209 5393181 SGTC_3131 9127911 49.47 µM 2.15310146791125 0.0267142509724619 no 131 0.0156553524630008 182 45595681 SGTC_3335 9143315 29.6265 µM 2.15098319166728 0.0268365743057397 no 132 0.0157387631961205 151 4899691 SGTC_2808 7946468 45.46 µM 2.14254132068544 0.027328719019322 no 133 0.0160749736561705 213 2970879 SGTC_665 3914-0008 307 µM 2.13524080009671 0.0277603734615715 no 134 0.016370672897023 189 1069549 SGTC_303 1348-1668 34.2 µM 2.13071581534604 0.0280307610733558 no 135 0.0165562806794436 144 5380509 SGTC_1012 4112-3522 18 µM 2.11512102575452 0.0289794746801461 no 136 0.0172098168155675 189 3112398 SGTC_905 2-aminofluorene 215 µM 2.11415805268788 0.029038921825308 no 137 0.0172508851286838 211 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3166 9102297 49.47 µM 2.11267315455506 0.0291307875052543 no 138 0.0173143762757505 216 25237072 SGTC_579 4491-1009 110 µM 2.11096647628507 0.0292366720783834 no 139 0.0173875967180564 255 1271041 SGTC_1005 4092-0690 4.4 µM 2.11082815490455 0.0292452677057115 no 140 0.0173935425921717 184 1529343 SGTC_768 0384-0033 77.3 µM 2.10378695761494 0.0296856057977084 no 141 0.0176985175020273 278 3965305 YMR134W ERG29 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.10032015542018 0.0299044236025039 no 142 0.0178503437090554 152 364106 SGTC_3250 9135583 49.47 µM 2.08745124809974 0.0307284154738853 no 143 0.018423681782906 142 7699353 SGTC_1256 0570-0116 285 µM 2.08265322611884 0.03104040355834 no 144 0.0186414219127109 196 410638 SGTC_794 k038-0031 316 µM 2.08186219269608 0.0310920907862072 no 145 0.0186775295062389 303 6624242 SGTC_2366 9070441 60.58 µM 2.08037290777827 0.0311895959729186 no 146 0.0187456711141073 218 6837235 SGTC_759 3486-0358 89.3 µM 2.0615567090461 0.03244344333792 no 147 0.0196249795911173 214 875103 SGTC_2823 7987624 58.44 µM 2.05740381718637 0.0327257078178971 no 148 0.0198236991389326 246 2239440 SGTC_3078 9116413 49.47 µM 2.0478022448723 0.0333860670527358 no 149 0.0202896901547672 206 17177322 SGTC_1015 4130-4525 82 µM 2.04702774219699 0.0334398092155793 no 150 0.0203276803681038 197 1363237 SGTC_1629 st005085 44.9 µM 2.04345614228924 0.0336885621986989 no 151 0.0205036523494152 234 24207091 SGTC_2996 9066192 71.4286 µM 2.0368132415501 0.0341552731071788 no 152 0.0208343804223188 245 6472854 SGTC_1158 4092-0494 91.8 µM 2.03057692466197 0.0345982434841528 no 153 0.0211489652454843 197 1148199 SGTC_1662 st014054 52 µM 2.02595077848056 0.0349298818264875 no 154 0.0213849144531073 153 2838777 SGTC_298 1391-0729 10 µM 2.02393362171402 0.0350753020983885 no 155 0.0214884909865634 183 3237558 SGTC_883 0850-0245 24.6 µM 2.01683501886678 0.0355910077534738 no 156 0.0218563665721473 245 6823229 YPR165W RHO1 SGTC_977 1348-1378 135 µM 2.00434262233128 0.0365136523366586 no 157 0.0225166855436799 216 X977 SGTC_2469 5655019 90.81 µM 1.98939918744299 0.0376429327337214 no 158 0.0233285796350136 226 2788239 SGTC_916 4466-0038 42 nM 1.98494839140719 0.0379847390705561 no 159 0.0235751068294611 338 5722064 YGL116W CDC20 SGTC_1847 st056231 15 µM 1.98494820655397 0.0379847533190777 no 160 0.023575117113712 281 5393180 SGTC_1292 0kpi-0043 232 µM 1.9778579856241 0.0385344851114623 no 161 0.0239723649111194 206 3333905 SGTC_2929 9013348 24.6 µM 1.96663976802828 0.0394175063419897 no 162 0.0246123776690923 233 2995952 SGTC_2521 angolensin 13.4 µM 1.96584226465561 0.0394809020137063 no 163 0.0246584169856529 183 821428 A flavenoid. SGTC_14 0354-0009 295 µM 1.96265914618381 0.0397347632500073 no 164 0.0248428965884422 233 1713507 SGTC_2716 st080858 38.6235 µM 1.96149016832017 0.0398283245466686 no 165 0.0249109353913812 197 5296050 SGTC_2990 9074105 71.4286 µM 1.95999932516849 0.0399479066783959 no 166 0.0249979345860371 186 6502001 SGTC_2352 9027995 87.8 µM 1.95908576191648 0.040021328645686 no 167 0.025051371976153 186 2997347 SGTC_2468 5987765 72.9 µM 1.95760647402432 0.0401404497205143 no 168 0.0251381035562787 210 26772094 SGTC_2895 9054447 58.44 µM 1.93470263676726 0.0420218263767011 no 169 0.026513398315643 186 2697450 SGTC_329 k048-0121 21.3 µM 1.9304852877214 0.0423759111640499 no 170 0.0267733682022592 224 6832902 SGTC_454 lyso-paf C-16 6.67 µM 1.92786278899442 0.0425973081375092 no 171 0.0269360976295763 239 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_346 4513-0042 7.16 µM 1.92234160306534 0.043066475876124 no 172 0.0272813941853192 270 2827372 SGTC_1545 lovastatin 49.4 µM 1.91886761166996 0.0433638150350289 no 173 0.0275005452444722 276 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2999 9069765 71.4286 µM 1.91764924581932 0.0434684868002158 no 174 0.0275777506678802 242 2097066 SGTC_340 k038-0059 454 µM 1.90909324884032 0.0442093034873913 no 175 0.028125031752009 259 23733424 SGTC_3066 9117245 49.47 µM 1.90632795865972 0.0444508994213445 no 176 0.0283038345104491 233 17176980 SGTC_950 1165-0508 94.1 µM 1.90559629470861 0.0445150005789955 no 177 0.0283513016198107 257 6148369 SGTC_3053 9095903 49.47 µM 1.9009004262559 0.0449281808163012 no 178 0.028657528131949 187 17174018 SGTC_3352 9151559 45.5865 µM 1.89854534600129 0.0451365590769487 no 179 0.0288121401132625 241 17159339 SGTC_3355 9151058 44.0485 µM 1.88516890409356 0.0463349063569021 no 180 0.0297035188230512 243 17015728 SGTC_1044 1222-0021 1.78 µM 1.8647858904736 0.0482099251395873 no 181 0.0311057108985951 282 4306703 SGTC_1873 rapamycin 2 nM 1.86152130676972 0.0485157951514241 no 182 0.0313352972985716 333 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_821 1114-0266 29.2 µM 1.85721124334846 0.0489219942533613 no 183 0.0316405530010792 248 3123235 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.85624749183936 0.0490131930938949 no 184 0.031709144806975 284 5106787 A p450 inhibitor. SGTC_1495 4469-0029 237 µM 1.85128164251379 0.0494852612975467 no 185 0.0320645228238984 415 793680 SGTC_1733 st037357 54.9 µM 1.84143160312378 0.0504323696631356 no 186 0.0327791675619769 302 1272339 YGL099W LSG1 SGTC_1197 1601-0112 267 µM 1.83952286707101 0.0506175597679278 no 187 0.0329191588443992 294 7350313 SGTC_2539 epi(13)torulosol 80 µM 1.83762230571438 0.0508024945192414 no 188 0.0330590398106255 280 6708597 SGTC_2734 clemastine 41.6 µM 1.83616957913354 0.0509442150185414 no 189 0.0331662901577265 115 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.83433415539075 0.0511237192665245 no 190 0.0333022035345099 234 229346 A bile salt which induces apoptosis. SGTC_3283 9109332 35.8195 µM 1.82516724811126 0.0520277883766092 no 191 0.0339878972957583 209 17027281 SGTC_2308 7584454 197.62 µM 1.82279449593808 0.0522638540414494 no 192 0.034167260839492 314 893577 SGTC_419 nsc-638432 893 µM 1.81918510342603 0.0526245835143705 no 193 0.0344415973673584 272 368090 SGTC_3097 9117246 49.47 µM 1.80957159587088 0.0535950196899748 no 194 0.0351811240180796 288 16423892 SGTC_2108 5365811 200 µM 1.79987895223606 0.0545877421791128 no 195 0.0359398768942433 298 780283 SGTC_2943 9068529 45.32 µM 1.79668841850859 0.054917679667978 no 196 0.0361925492978266 309 3270634 SGTC_3113 9123498 49.47 µM 1.79600528870924 0.0549885274923317 no 197 0.0362468379589127 245 8897275 SGTC_853 0419-0306 21 µM 1.78885237132586 0.0557347056738374 no 198 0.036819297010293 254 762713 SGTC_924 2046-0044 21.3 µM 1.78876237025378 0.0557441450559294 no 199 0.0368265467614486 278 3623589 SGTC_1427 4048-4900 550 nM 1.78749493778591 0.055877208370099 no 200 0.0369287647858747 279 24132586 SGTC_1874 staurosporine 7.6 µM 1.78641382087339 0.0559909089898901 no 201 0.0370161397299661 313 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_956 1185-0240 191 µM 1.78460267657145 0.0561817951359661 no 202 0.0371628934852779 281 1416193 SGTC_1951 sophoraflavanone G 9.2 µM 1.78288962207706 0.0563628149182239 no 203 0.0373021363840173 313 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_496 calpeptin 138 µM 1.78233661274199 0.0564213499001742 no 204 0.0373471777635998 264 73364 A calpain inhibitor. SGTC_316 k060-0003 58.6 µM 1.78077794153434 0.0565865901221112 no 205 0.0374743671832107 263 6152314 SGTC_708 3448-5400 146 µM 1.78042365706336 0.0566242021987766 no 206 0.0375033265023164 327 3462195 SGTC_2463 5473429 200 µM 1.77858263741036 0.0568199684796969 no 207 0.0376541063640258 259 5399405 SGTC_1645 Cervolide 78 µM 1.774488883206 0.0572571914538341 no 208 0.0379911596528489 246 23173 A fragrance. SGTC_2095 5432005 200 µM 1.77353022927465 0.0573599596663966 no 209 0.0380704436844865 258 783734 SGTC_45 0kpi-0036 14.9 µM 1.77029964240374 0.0577073492321931 no 210 0.0383386188100852 268 2795021 SGTC_1485 3909-9022 254 µM 1.76822276837865 0.0579315506474575 no 211 0.0385118346441948 282 714516 SGTC_1362 1611-0397 101 µM 1.76390675544411 0.0583996596072129 no 212 0.0388738396583907 287 27816 SGTC_1637 st007924 17.4 µM 1.76187746360483 0.0586207781227773 no 213 0.0390450015249908 289 683336 SGTC_1747 st037496 66.6 µM 1.76057906372862 0.0587626006193477 no 214 0.0391548373814071 325 723305 SGTC_129 0088-0017 176.636 µM 1.75228014058529 0.0596754518029346 no 215 0.0398628245854117 339 182446 SGTC_137 0438-0332 85.389 µM 1.74574171666167 0.0604024502341104 no 216 0.0404279213297722 477 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1134 3477-0009 42.5 µM 1.74387733426184 0.0606110132366778 no 217 0.0405902408511914 359 3973534 SGTC_3211 9128781 49.47 µM 1.74112918071708 0.0609194678035653 no 218 0.0408304686976631 352 17194361 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.73915382154459 0.061141940541619 no 219 0.0410038548315058 290 641818 YHR062C RPP1 SGTC_1342 1486-1464 234 µM 1.72652237409751 0.0625795879988571 no 220 0.0421267388340448 308 3253938 SGTC_1826 st055655 41.6 µM 1.7257500069432 0.062668342650814 no 221 0.0421961986548398 337 676168 SGTC_3233 9132340 49.47 µM 1.72569518116789 0.0626746465459051 no 222 0.0422011327172498 300 17682950 SGTC_1408 3909-7976 48.8 µM 1.7255809736798 0.0626877797671095 no 223 0.042211412354226 359 24152374 SGTC_3036 9090181 49.47 µM 1.7233502111406 0.0629447352879749 no 224 0.0424126063987852 256 25236586 SGTC_332 4112-0506 40.9 µM 1.71696942482722 0.0636842518973722 no 225 0.0429923793164838 296 2790355 SGTC_2872 9044037 25.97 µM 1.71474549983507 0.0639435816638466 no 226 0.0431959487982149 225 6465195 SGTC_3143 9086658 49.47 µM 1.70879510627887 0.0646414898840295 no 227 0.0437444547712315 396 25236626 SGTC_2752 diclazuril 33.15 µM 1.7063282303491 0.0649325531367119 no 228 0.0439734924097364 487 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2009 4012297 12.05 µM 1.70386965173225 0.0652236486365607 no 229 0.0442027209301509 343 45595307 SGTC_197 4544-0043 41.561 µM 1.70368865235972 0.0652451188974096 no 230 0.0442196346198348 378 896523 SGTC_709 3807-1509 243 µM 1.69981857964564 0.0657055026375098 no 231 0.0445825278068146 250 1886677 YPL242C IQG1 SGTC_2153 5569715 200 µM 1.6987257271486 0.0658359632717121 no 232 0.0446854368129039 275 2054701 SGTC_2812 7970281 58.44 µM 1.69621710319901 0.0661361926999589 no 233 0.0449223863066829 366 2233435 SGTC_3089 9117425 49.47 µM 1.69562678910679 0.0662069947708121 no 234 0.0449782905689464 325 9401657 SGTC_1278 0874-0585 172 µM 1.6924764414026 0.0665858395011312 no 235 0.0452775841327467 306 766306 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.69108282533398 0.0667539630284446 no 236 0.0454104924557566 347 16486 A toxic proline analog. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.68718727092143 0.0672256587527072 no 237 0.0457836741141426 408 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1762 st045503 25.4615 µM 1.68430067494426 0.0675768432580226 no 238 0.0460617875183705 341 4645554 SGTC_3025 9087895 49.47 µM 1.68054171934449 0.0680362822212396 no 239 0.0464259821525392 336 17173641 SGTC_2389 9091542 195.52 µM 1.66846054228107 0.0695292461461598 no 240 0.0476121692528555 374 3626624 YOL127W RPL25 SGTC_1466 k213-0079 57.5 µM 1.66784024531237 0.0696065765432493 no 241 0.0476737221531423 337 3657981 SGTC_1937 st074714 47.2 µM 1.66494047320021 0.0699689602883115 no 242 0.0479623162251168 359 17250970 SGTC_1757 st041620 31.8375 µM 1.66412964246412 0.0700705488465848 no 243 0.0480432622325997 345 5289815 SGTC_2623 humulene 100 µM 1.66326096715056 0.070179510582509 no 244 0.0481301041923341 283 6187145 An anti-inflammatory. SGTC_521 r062-0005 13.8 µM 1.65856682528705 0.0707705735354557 no 245 0.04860155567385 333 2832033 SGTC_518 1021-0119 62.6 µM 1.65811667392662 0.0708274547365425 no 246 0.0486469595139439 368 1097762 SGTC_687 k029-0044 34.9 µM 1.65811138698057 0.0708281230045532 no 247 0.0486474929752024 342 5829338 SGTC_3279 9140807 49.47 µM 1.653365977379 0.0714298967675724 no 248 0.0491282013702942 310 45595718 SGTC_2120 5538279 151.968 µM 1.65330714202131 0.0714373823334517 no 249 0.0491341850970236 343 2058197 SGTC_196 k015-0023 18.111 µM 1.64808170432412 0.0721046138932677 no 250 0.0496679530678061 364 5211998 SGTC_748 act1.228 77.9 µM 1.64633368302949 0.0723288803369724 no 251 0.0498475391806701 410 4421505 YNR035C ARC35 SGTC_607 4491-0986 66.8 µM 1.63893578644899 0.073283932119822 no 252 0.0506133168635876 360 698981 YDR232W HEM1 SGTC_158 k038-0087 26.446 µM 1.63476924412747 0.0738260536906712 no 253 0.0510487152289342 489 X158 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.63420445401058 0.0738997755460056 no 254 0.0511079638227527 336 2346 DNA damaging agent; causes G2/M arrest. SGTC_2720 fluspirilene 36.88 µM 1.63403649818838 0.0739217096090126 no 255 0.0511255935686865 276 3396 An atypical antipsychotic. SGTC_321 4534-3890 65.3 µM 1.62251856871755 0.0754377837675868 no 256 0.0523461802592817 323 699746 SGTC_3212 9128307 49.47 µM 1.62226502043835 0.0754714222348791 no 257 0.0523733074930399 356 27243542 SGTC_273 hydroxyurea 18.1 mM 1.6211372207899 0.0756211868982752 no 258 0.0524941065030928 422 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_278 4092-0821 23.9 µM 1.618028557343 0.0760351699391186 no 259 0.0528282217239153 347 877900 SGTC_1459 k035-0031 35.7 µM 1.61513768907396 0.0764216952623395 no 260 0.053140440362336 299 3877128 YMR208W ERG12 SGTC_2170 morpholine 200 µM 1.61140754405865 0.0769226432840836 no 261 0.0535454620106192 309 121171 Reacts with secondary amines. SGTC_1148 3909-7663 27.7 µM 1.61101314059635 0.0769757561421877 no 262 0.0535884291874578 365 4084526 SGTC_2376 9072922 81.32 µM 1.61088017929676 0.0769936678305693 no 263 0.0536029204372211 400 17087968 SGTC_82 0054-0107 293.755 µM 1.60856183655827 0.0773064893954662 no 264 0.0538560923699695 320 3104697 SGTC_2433 5607874 27.82 µM 1.60838500682746 0.0773303891811061 no 265 0.0538754416534912 372 2252428 SGTC_440 fluspirilene 35.1 µM 1.60587405799086 0.077670367599891 no 266 0.0541507922546313 375 3396 An atypical antipsychotic. SGTC_1697 st025554 27.742 µM 1.60503628953808 0.0777840521906 no 267 0.0542429093099204 326 1269519 SGTC_354 2783-3500 4.88 µM 1.60453607887407 0.0778519906180874 no 268 0.0542979691982982 393 6740761 SGTC_572 0960-0087 17.7 µM 1.60186042456322 0.0782161619134258 no 269 0.0545932388019441 430 6796365 SGTC_1046 2001-0062 216 µM 1.60148424488556 0.0782674654641301 no 270 0.0546348534090288 377 739778 SGTC_2496 diffractaic acid 79.83 µM 1.59852230246643 0.0786723083889794 no 271 0.0549633930009259 396 94870 An apoptosis inducer which activates caspases. SGTC_2312 7706453 155.7 µM 1.59701494874938 0.0788789442122541 no 272 0.0551311875334857 378 976098 SGTC_1111 tnp00062 510.699 nM 1.59556424466986 0.0790782022321539 no 273 0.055293057875027 343 676306 SGTC_2659 sanguinarine 24.21 µM 1.59327013564728 0.079394081840563 no 274 0.0555498016334314 356 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2450 5739737 12.93 µM 1.5907866223815 0.0797371163929317 no 275 0.0558288022962376 359 2262825 SGTC_2636 apigenin dimethyl ether 100 µM 1.58602510477117 0.0803979332262112 no 276 0.0563668073931566 438 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_289 k017-0060 526 µM 1.58416548427008 0.0806571372382914 no 277 0.0565780328022075 320 5512909 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.58407841567863 0.0806692887804385 no 278 0.056587937770773 427 6708784 An antioxidant flavonoid SGTC_79 0052-0007 94.094 µM 1.5827349940033 0.0808569558407399 no 279 0.0567409393603988 377 2801472 SGTC_667 1498-1044 59 µM 1.57717384358726 0.0816373189153948 no 280 0.0573777648665342 388 6739982 SGTC_2197 6588183 93.1375 µM 1.57685658138686 0.0816820090467634 no 281 0.0574142644754317 311 884136 SGTC_637 1181-0519 7.26 µM 1.57515476345377 0.0819220450740955 no 282 0.057610362966248 512 6252091 YGR060W ERG25 SGTC_2314 7727897 200 µM 1.57447359892209 0.0820182699930687 no 283 0.0576890002175884 368 900724 SGTC_2293 7624732 200 µM 1.5733640034429 0.0821751996519028 no 284 0.0578172785199575 361 894453 SGTC_403 arphamenine a 50 µM 1.57284622011223 0.0822485068964268 no 285 0.0578772151903365 398 5487158 An arginine aminopeptidase inhibitor. SGTC_1221 2958-7315 257 µM 1.5727327298344 0.0822645813149601 no 286 0.0578903589260904 394 4562705 SGTC_1588 farnesol 29.9 µM 1.5722212568847 0.0823370541512367 no 287 0.0579496236488932 384 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_307 1501-1223 22.3 µM 1.57191524931943 0.0823804366808658 no 288 0.0579851037497856 361 2830329 SGTC_64 000l-0018 272.079 µM 1.57114097617466 0.0824902818387747 no 289 0.0580749532373956 540 6811119 SGTC_1966 st070145 16.1 µM 1.56984061419998 0.0826750106004272 no 290 0.058226098117542 370 3748532 SGTC_1351 1496-0003 46.5 µM 1.56315785288521 0.0836292742913694 no 291 0.0590077353997839 391 3891978 SGTC_1865 st057639 52.2 µM 1.56307583071461 0.0836410378257452 no 292 0.0590173798623237 401 688818 SGTC_2026 5148700 152 µM 1.56229738418605 0.0837527437131777 no 293 0.0591089739835032 383 79838 SGTC_2029 5175081 200 µM 1.55722004186023 0.0844840853015647 no 294 0.0597091257839206 432 1380876 SGTC_3348 9149464 3.537 µM 1.55645767997101 0.0845943085273599 no 295 0.0597996492621523 377 1951442 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.55229947371792 0.0851974064832041 no 296 0.0602952918996038 478 368090 SGTC_1133 3473-0247 50 µM 1.54976262469387 0.0855669250087468 no 297 0.0605992504163799 432 711311 SGTC_1086 cerivastatin 2.18 µM 1.54735265928207 0.0859190719510976 no 298 0.0608891150676486 355 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3258 9138477 49.47 µM 1.54572530278062 0.0861574758887386 no 299 0.0610854618531243 367 4970355 SGTC_873 0591-4978 488 µM 1.54024252186408 0.0869643328262222 no 300 0.0617506242636531 419 3305145 SGTC_2679 rapamycin 1 nM 1.5381856139664 0.0872684830669781 no 301 0.0620016187189172 535 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1802 st050112 57.9 µM 1.53523444869726 0.0877062512771921 no 302 0.0623631246609029 392 4662563 SGTC_1819 st053448 58.6 µM 1.53431729252193 0.0878426329826353 no 303 0.0624758067853588 386 2857616 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.53386004206128 0.0879106854750601 no 304 0.0625320440018981 456 5024745 SGTC_2283 7944793 200 µM 1.53224947903881 0.0881506983891842 no 305 0.0627304414363448 423 2970533 SGTC_1220 1838-0075 193 µM 1.53037629324967 0.0884304625269467 no 306 0.0629618067664068 413 5529645 SGTC_475 α-linolenic acid 10 µM 1.52836888980984 0.0887310061405163 no 307 0.0632104872252979 422 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2218 6965428 192.983 µM 1.52747656976897 0.0888648461064725 no 308 0.0633212745572718 380 675684 SGTC_2595 hexamethylquercetagetin 100 µM 1.52722663649872 0.0889023607776723 no 309 0.0633523324811655 385 386331 SGTC_1983 st071813 46.9 µM 1.52604015076163 0.0890806116547073 no 310 0.0634999327657694 402 11838595 SGTC_648 0375-0473 33.3 µM 1.52565878792548 0.0891379618921228 no 311 0.0635474315645125 441 1713139 SGTC_2773 thioridazine 9.09 µM 1.52325041349938 0.0895007736935062 no 312 0.063848033873593 405 5452 An antipsychotic. SGTC_1833 st055984 71 µM 1.52019002258431 0.0899633921800303 no 313 0.0642316121482626 377 676288 SGTC_3077 9117319 49.47 µM 1.52012474206441 0.0899732795122367 no 314 0.0642398136387813 339 17154678 SGTC_741 4582-0002 126 µM 1.51911272619017 0.0901266618863706 no 315 0.064367061966016 405 2912688 SGTC_2787 5284540 71.43 µM 1.51878779030227 0.0901759507455623 no 316 0.0644079600994179 416 736958 SGTC_3296 9122258 64.045 µM 1.51865344409882 0.090196335295812 no 317 0.0644248755152782 421 4730474 SGTC_1076 itraconazole 331 nM 1.51732968937409 0.0903973736324672 no 318 0.0645917329610583 417 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1317 1273-0028 910 nM 1.51566292196173 0.090650978223429 no 319 0.064802303867275 403 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2731 amoxapine 43.43 µM 1.51552725341371 0.0906716438934378 no 320 0.0648194669718508 235 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1169 aniline yellow 25.8 µM 1.5140205556667 0.0909013862601162 no 321 0.0650103130464126 363 6051 A DNA damaging agent. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.51300773516141 0.0910560644189048 no 322 0.065138847023833 495 91467 include heat shock SGTC_3051 9093778 49.47 µM 1.51022441391979 0.0914821390847797 no 323 0.0654930855496608 312 17217378 SGTC_2674 ligustilide 100 µM 1.50621166403068 0.0920990146841837 no 324 0.0660064230573914 372 5319022 A signalling regulator. SGTC_1575 cyproterone acetate 48 µM 1.50617772357047 0.092104245415643 no 325 0.0660107782030588 409 9880 An androgen receptor antagonist and liver toxin. SGTC_397 arbidol 50 µM 1.50607450914537 0.0921201536504091 no 326 0.0660240237597167 444 131410 A RNA synthesis inhibitor. SGTC_3136 9095672 49.47 µM 1.50322081353352 0.0925607940763173 no 327 0.0663910560183847 357 17217380 SGTC_184 1494-0393 24.714 µM 1.50202881835145 0.092745311551547 no 328 0.0665448331994143 441 3090647 SGTC_2845 9003024 42.97 µM 1.49749394890002 0.0934497827039913 no 329 0.0671323894626298 448 2990173 SGTC_3167 9103034 49.47 µM 1.49668738532758 0.0935754915599172 no 330 0.0672373100745476 324 5127859 SGTC_216 k038-0035 28.382 µM 1.49596681209698 0.0936879037675069 no 331 0.0673311519461998 376 4444231 YPR107C YTH1 SGTC_723 4182-0001 115 µM 1.4919061577571 0.094323246083378 no 332 0.0678618740873891 410 744821 YLR208W SEC13 SGTC_1985 st071382 65.5 µM 1.48926986090895 0.0947374268251047 no 333 0.0682081604312564 413 6123237 SGTC_364 0083-0097 67.7 µM 1.4877888447576 0.0949706920519468 no 334 0.0684032942319558 421 5207356 SGTC_2987 9018338 71.43 µM 1.48620568700817 0.0952205125303424 no 335 0.0686123618782384 439 5055682 SGTC_2173 5763948 167 µM 1.48604249672986 0.0952462912540786 no 336 0.0686339403455015 443 2867177 SGTC_3274 9138298 49.47 µM 1.48482626179041 0.0954385784578141 no 337 0.0687949266255498 450 17015756 SGTC_3322 9139058 2.11 µM 1.47978883166388 0.0962380410552307 no 338 0.069464805047811 423 4908926 YPR165W RHO1 SGTC_3127 9126946 49.47 µM 1.47924955517826 0.09632391746695 no 339 0.0695368147857544 381 27243249 SGTC_1156 4092-0367 4.88 µM 1.47904711488226 0.0963561693542542 no 340 0.069563861528414 451 1357585 SGTC_3007 9078383 71.4286 µM 1.47679605875904 0.0967153324845891 no 341 0.0698651566882096 426 6496995 SGTC_2222 6885208 172.143 µM 1.47530426923419 0.0969538933299184 no 342 0.0700653795859069 359 609514 SGTC_3023 9089636 49.47 µM 1.47131854625924 0.0975933921898778 no 343 0.0706024949963338 425 17249241 SGTC_3092 9117248 49.47 µM 1.47056695010939 0.097714329680205 no 344 0.0707041336949876 419 17141857 SGTC_800 3448-7362 155 µM 1.46638613991316 0.0983890595131531 no 345 0.0712715600448632 722 15991913 SGTC_631 k072-0230 41.5 µM 1.4661986032704 0.0984194053082323 no 346 0.071297094508717 475 5773147 SGTC_2079 5212404 121 µM 1.4642942514356 0.0987279416853806 no 347 0.0715567835912804 411 758462 SGTC_488 nitrendipine 139 µM 1.4625467215994 0.0990116926175949 no 348 0.0717957254849103 458 4507 Dihydropyridine L-type calcium channel blocker. SGTC_138 0850-0259 40.9225 µM 1.46240718888986 0.0990343745952104 no 349 0.0718148303132576 615 6813004 SGTC_1510 1123-0200 71.5 µM 1.45987216046352 0.0994471224726387 no 350 0.072162605872062 518 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3006 9075424 71.4286 µM 1.45189711626279 0.100753799743231 no 351 0.0732651072572434 425 7465181 SGTC_3130 9127414 49.47 µM 1.44378089674643 0.102096418075193 no 352 0.0744003086232839 407 1494646 SGTC_746 1095-0025 46.6 µM 1.44085828203388 0.10258306265745 no 353 0.0748123620001223 468 6749286 SGTC_17 0960-0276 49.807 µM 1.44075460507574 0.102600356824166 no 354 0.0748270111126694 497 6821114 SGTC_81 0411-0046 9.971 µM 1.43967280676694 0.102780936095911 no 355 0.0749799951823029 420 12925265 SGTC_2053 5265679 138 µM 1.43947458321941 0.10281404959978 no 356 0.0750080530948285 483 764595 SGTC_2330 7979373 200 µM 1.43932320443463 0.102839342844625 no 357 0.0750294856724722 473 1863007 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.43735882317348 0.10316797314321 no 358 0.075308031277288 367 4620898 SGTC_1526 st051518 75 µM 1.43390897297583 0.103746958819855 no 359 0.0757991204552227 415 673993 SGTC_2018 5133068 143 µM 1.43350356268721 0.103815152989476 no 360 0.0758569907526664 458 785362 SGTC_181 1447-1644 8.07 µM 1.43295166912209 0.103908039400174 no 361 0.0759358248800363 453 534600 SGTC_1167 k781-0610 148 µM 1.42888261401829 0.104594742391476 no 362 0.0765189876532379 500 4525169 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.42643622567236 0.105009179577769 no 363 0.0768712316427684 493 6708561 SGTC_1436 4092-1007 8.32 µM 1.42587316434474 0.105104734586164 no 364 0.0769524784419435 435 2881121 SGTC_3054 9094397 49.47 µM 1.42245399079208 0.105686341139608 no 365 0.0774472495112871 497 2598354 SGTC_854 0422-0053 192 µM 1.42114686121649 0.105909299525831 no 366 0.0776370345700717 452 3596728 SGTC_1534 6-azauridine 81.6 µM 1.41835483752927 0.106386675852428 no 367 0.0780435970044743 525 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1102 cgs 12066b 26.1 µM 1.41619072518227 0.106757760251114 no 368 0.0783598353382834 434 6438352 A 5-HT1B full agonist. SGTC_1191 1487-1166 10.6 µM 1.41577599083309 0.106828982052389 no 369 0.0784205506082966 545 3955771 SGTC_528 3492-0019 172 µM 1.41332161838148 0.107251170154806 no 370 0.0787805901792599 705 2869262 SGTC_2838 9002687 71.43 µM 1.4123166129696 0.107424392541753 no 371 0.0789283784708331 424 6457060 SGTC_2968 9090663 33.37 µM 1.40692839598962 0.108356543054316 no 372 0.0797243111958272 481 25236811 SGTC_1963 st076565 50.3 µM 1.40518277517347 0.108659776539123 no 373 0.0799834673976894 471 4914280 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.40485087694886 0.108717499886759 no 374 0.0800328132492154 501 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2081 5214970 32.255 µM 1.40240918374946 0.109142834236691 no 375 0.0803965462516 461 2063512 SGTC_2302 7771753 200 µM 1.40163702591617 0.109277589950283 no 376 0.0805118322604091 527 2203047 SGTC_3281 9140613 49.47 µM 1.40118997483051 0.109355663184068 no 377 0.0805786356919088 422 16013766 SGTC_157 1348-1695 65.819 µM 1.39549333736564 0.110354036917538 no 378 0.0814335612736958 563 5380510 SGTC_2465 5809242 33.21 µM 1.39202819171497 0.110964514652075 no 379 0.0819569305821305 431 2731748 SGTC_2234 tolnaftate 200 µM 1.39127073673021 0.11109828210067 no 380 0.082071672048969 380 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1888 azatryptophan 97.5 µM 1.38907853389901 0.111486078360646 no 381 0.0824044352308523 429 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1562 morin hydrate 59.1 µM 1.38646721941774 0.111949277636348 no 382 0.0828021415961992 468 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1594 piperine 70.1 µM 1.38452941780896 0.112293896438675 no 383 0.0830982034012568 505 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_96 0929-0093 37.281 µM 1.38307480568993 0.112553082430669 no 384 0.0833209649618508 462 6991579 SGTC_2440 5628896 157.78 µM 1.38039884729073 0.113031006110613 no 385 0.083731937454529 458 5522048 SGTC_1413 3910-0535 34.4 µM 1.37689615385018 0.113658770051879 no 386 0.0842721782554367 491 2876951 SGTC_1416 3966-0321 25.3 µM 1.37576112750239 0.113862725307918 no 387 0.0844477999808868 507 582530 YLR208W SEC13 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.37072200893544 0.114771364156205 no 388 0.085230815612788 481 4330530 SGTC_3268 9137683 49.47 µM 1.37057681093193 0.114797622075326 no 389 0.0852534579145806 434 1953228 SGTC_1884 5633444 25 µM 1.36981612302502 0.114935256359559 no 390 0.0853721538992453 536 5724239 SGTC_2061 5245884 80.95 µM 1.36698812206937 0.115447966940595 no 391 0.0858145143008153 520 573863 SGTC_305 1682-2595 20.8 µM 1.36479524145113 0.11584664876704 no 392 0.0861587074246638 517 226033 SGTC_1617 st002906 78 µM 1.36388619899147 0.116012205690307 no 393 0.0863016925347271 531 5150859 SGTC_1206 3978-0017 132 µM 1.35560548230153 0.117528045695313 no 394 0.0876123632964551 471 3873677 SGTC_1719 st032227 49.2 µM 1.35557403271398 0.117533829354628 no 395 0.0876173692881811 504 3125804 SGTC_379 3970-0972 5.9 µM 1.35532275047614 0.117580048035683 no 396 0.0876573748327526 501 2898042 YBL034C STU1 SGTC_2028 5153890 36.43 µM 1.35333980269686 0.117945225702252 no 397 0.0879735494964395 507 2830968 YPR165W RHO1 SGTC_1464 k208-0027 110 µM 1.35258312668841 0.118084785678617 no 398 0.088094422965938 532 X1464 SGTC_714 4296-0578 26.1 µM 1.34843244480265 0.118852407604011 no 399 0.0887596672569299 403 1589775 SGTC_1597 7-benzyloxygramine 47.5 µM 1.34743683605703 0.119037057162025 no 400 0.0889197918081979 664 260807 SGTC_3094 9117742 49.47 µM 1.34705377079362 0.119108155900137 no 401 0.0889814577568697 541 17149698 SGTC_483 fpl-64176 144 µM 1.34644738120434 0.119220765980016 no 402 0.0890791395892257 427 3423 SGTC_2216 7189485 200 µM 1.34577622751892 0.119345490721539 no 403 0.0891873471386918 492 731273 SGTC_3070 9117005 49.47 µM 1.34273400726961 0.119912000344532 no 404 0.089679059414757 420 8779016 SGTC_1775 st081588 35.1725 µM 1.34188741077792 0.120069986657702 no 405 0.0898162521350829 567 1426443 YGL099W LSG1 SGTC_2635 hydroquinidine 100 µM 1.34174208852649 0.120097120492995 no 406 0.0898398175874442 520 442912 An experimental heart treatment. SGTC_926 2268-1401 59.4 µM 1.3402698685411 0.120372249610384 no 407 0.090078811900373 529 2931578 SGTC_449 xestospongin c 11.1929 µM 1.3365798841478 0.121063785505072 no 408 0.0906799044098031 556 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.33504479291852 0.121352296905047 no 409 0.0909308432720961 558 688667 SGTC_1979 st071809 45.3 µM 1.33383567075247 0.121579884441653 no 410 0.0911288589167297 508 4976333 SGTC_1942 st076330 65.2 µM 1.3309267560086 0.122128644710464 no 411 0.0916065562039742 514 24208414 SGTC_1487 3970-0795 2.82 µM 1.32890061464924 0.122511897847833 no 412 0.0919403805178006 545 3765103 SGTC_2232 chlorophetanol 41.5365 µM 1.32841260953036 0.122604332032336 no 413 0.0920209180386447 680 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1154 4088-0362 150 µM 1.32526703138444 0.123201317432397 no 414 0.0925412998569873 594 6618304 SGTC_2673 kobusone 100 µM 1.32057041540352 0.124096453951837 no 415 0.0933223213787815 500 6710676 An epoxy ketone and protein crosslinker. SGTC_2931 9014674 55.67 µM 1.32031702773731 0.124144876605243 no 416 0.0933645963938561 513 2996810 SGTC_786 4544-0069 423 µM 1.31781347587555 0.124624018613755 no 417 0.093783047828954 571 748821 YLR208W SEC13 SGTC_720 r052-1644 49.9 µM 1.31471036642081 0.125219698954411 no 418 0.0943036306407364 467 1422863 YOR257W CDC31 SGTC_1781 st038725 66.3 µM 1.3140783853199 0.12534125883776 no 419 0.0944099135698988 627 4270275 YIL048W NEO1 SGTC_2078 5212016 200 µM 1.31347750652487 0.125456912650962 no 420 0.0945110477826829 477 1899708 SGTC_1520 flindersine 88 µM 1.31269087215826 0.125608432213468 no 421 0.094643567307334 552 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1572 epiandrosterone 68.9 µM 1.31069751543817 0.125992959235267 no 422 0.0949799892143019 573 441302 A steroid. SGTC_1980 st071811 45.7 µM 1.30994236373455 0.126138845373004 no 423 0.0951076671508954 523 4974850 SGTC_506 n9-isopropylolomoucine 153 µM 1.30934440466577 0.126254447308271 no 424 0.0952088572467808 519 6610355 SGTC_2643 anethole 100 µM 1.30743398049252 0.12662427956103 no 425 0.0955326815232358 561 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_102 gallobenzophenone 83.616 µM 1.30446091053431 0.127201325207629 no 426 0.0960382394957086 571 70837 SGTC_679 0422-0091 41.4 µM 1.30363683943875 0.127361593194538 no 427 0.0961787168869845 576 627384 YHR062C RPP1 SGTC_2719 novobiocin 32.65 µM 1.29859622459754 0.12834496494987 no 428 0.0970412671570368 450 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2367 9070478 135.38 µM 1.29833855739348 0.128395374390476 no 429 0.0970855112350147 576 572802 SGTC_2261 9010538 184.68 µM 1.29776414633607 0.128507800366666 no 430 0.0971841967411596 463 6457250 SGTC_846 0335-0850 148 µM 1.29484987307053 0.129079245946173 no 431 0.0976860117457456 511 6819598 SGTC_452 diindolylmethane 8 µM 1.29354969392516 0.129334759241053 no 432 0.0979105042487911 482 3071 Inhibits expression of several cancer promoting factors. SGTC_857 0438-0306 1.35 µM 1.29184815840959 0.129669676973571 no 433 0.0982048669420947 550 4686136 SGTC_1282 0886-0010 32.4 µM 1.29184083360714 0.129671120031104 no 434 0.0982061355200485 624 2836211 YNL267W PIK1 SGTC_2614 arthonioic acid 13.39 µM 1.29151024264082 0.12973626125612 no 435 0.0982634028602306 488 6710684 SGTC_2858 9025781 8.96 µM 1.29079436121181 0.129877399618761 no 436 0.0983874968051364 684 4894980 YPL153C RAD53 SGTC_392 N-ethylmaleimide 8.33 µM 1.29066725922246 0.129902469299601 no 437 0.0984095411981601 521 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2434 5670830 169.91 µM 1.28975206546082 0.130083081635273 no 438 0.0985683779263352 559 1549830 SGTC_2190 6049624 200 µM 1.28946817940406 0.130139141490557 no 439 0.0986176859729039 473 2265554 SGTC_500 h-89 112 µM 1.28857948964666 0.130314741876042 no 440 0.0987721588396099 596 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2528 xanthyletin 44.79 µM 1.28718246741589 0.130591117311281 no 441 0.0990153483664706 520 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1614 st002383 48.6 µM 1.2868785417079 0.130651297121406 no 442 0.0990683128199473 557 1947235 SGTC_143 4032-1194 15.74 µM 1.28585678491839 0.130853754004269 no 443 0.0992465240228494 653 1806963 SGTC_3191 9110352 49.47 µM 1.28245767902601 0.131528832746712 no 444 0.0998410709117881 521 17122424 SGTC_1687 st020778 55.3625 µM 1.28068323024481 0.131882200215483 no 445 0.100152476200793 718 4259299 SGTC_1013 4112-3890 241 µM 1.27875845493343 0.132266243870537 no 446 0.100491063976403 585 705171 SGTC_439 amiodarone 34.4 µM 1.27832712953253 0.132352410338625 no 447 0.100567052964146 624 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1789 tunicamycin 25 nM 1.27597851271948 0.132822275575944 no 448 0.100981557447682 542 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2210 7115885 190.385 µM 1.27445240345 0.133128204604207 no 449 0.101251565318497 585 2927039 SGTC_2793 7325131 81.82 µM 1.27181681715605 0.133657684381699 no 450 0.101719106165037 513 4176441 SGTC_1073 triclabendazole 3.09 µM 1.27045067489864 0.133932706450604 no 451 0.101962071114205 634 50248 An antihelmetic and likely tubulin inhibitor. SGTC_525 k781-2675 26.7 µM 1.2692377499213 0.13417720960909 no 452 0.102178140459809 604 3651118 YDL195W SEC31 SGTC_3320 9137005 35.139 µM 1.26920530530892 0.13418375404831 no 453 0.102183924683886 537 4908713 SGTC_270 tamoxifen 5.46 µM 1.26894050164239 0.134237176091014 no 454 0.10223114277577 606 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_15 0266-0086 27.098 µM 1.26682262842581 0.134664965862753 no 455 0.102609359514152 678 1712902 YIL048W NEO1 SGTC_1028 k015-0029 4.8 µM 1.26665684167493 0.134698492614458 no 456 0.102639009125535 597 4588309 SGTC_3026 9090633 49.47 µM 1.26567511076229 0.134897143649443 no 457 0.102814711340642 571 25236842 SGTC_710 3448-4187 58 µM 1.26492977291562 0.135048095227364 no 458 0.102948251726395 671 3946412 SGTC_2379 9035213 200 µM 1.26343648954986 0.135350874946465 no 459 0.10321617873929 622 646551 SGTC_623 k072-0108 16.9 µM 1.26314981902004 0.13540905376084 no 460 0.103267671449515 574 5382803 SGTC_3046 9092212 49.47 µM 1.25809209882996 0.136438319987629 no 461 0.104179225234186 548 25236637 SGTC_2676 harmalol 100 µM 1.2579237297083 0.136472675571595 no 462 0.104209670430745 603 5459187 A monoamine oxidase inhibitor SGTC_3110 9122132 49.47 µM 1.25610313061716 0.136844545277355 no 463 0.104539290623955 588 918317 SGTC_575 k072-0246 11.9 µM 1.25498207991428 0.137073871718078 no 464 0.104742632673106 582 6796779 SGTC_1140 3229-1848 2.98 µM 1.25332427228018 0.137413480227061 no 465 0.105043859254583 584 2849525 SGTC_3 0833-0587 95.581 µM 1.2522177666125 0.137640471765408 no 466 0.105245261909782 571 5382644 SGTC_1480 1070-0044 41.2 µM 1.25169930047585 0.137746919299473 no 467 0.105339727543463 580 3124987 SGTC_421 streptovitacin 30 mM 1.25072803684835 0.137946482936302 no 468 0.10551685890257 630 91467 include heat shock SGTC_2810 7959871 45.46 µM 1.24935998770775 0.138227907695647 no 469 0.105766718091122 634 2974535 SGTC_1611 st001856 99.4 µM 1.24834251981526 0.138437467170065 no 470 0.105952824597626 556 647478 SGTC_844 0330-0132 15.3 µM 1.24680664126173 0.138754209319706 no 471 0.106234202383007 585 2828079 SGTC_611 3453-1652 23.7 µM 1.24627569768246 0.138863819812988 no 472 0.106331598348874 621 1560575 SGTC_2979 9012552 45.46 µM 1.2440451572347 0.139324947160108 no 473 0.106741471827841 519 17100905 SGTC_1531 st059297 52.4 µM 1.24341850444593 0.139454684510172 no 474 0.106856827443093 606 7566702 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.24078457129381 0.140000892081726 no 475 0.107342671164671 618 2724 A muscle relaxant with antifungal properties. SGTC_3002 9075603 71.4286 µM 1.24070132778232 0.140018178233873 no 476 0.107358051813031 615 20105405 SGTC_1805 st050013 60.3 µM 1.24068618617773 0.140021322659816 no 477 0.107360849651639 550 4037144 SGTC_1205 4161-2785 76 µM 1.23853614201389 0.140468305099914 no 478 0.107758664747202 518 3498106 SGTC_2975 9084847 53.72 µM 1.23826551846295 0.140524634822828 no 479 0.107808812409769 606 27211724 SGTC_3273 9137859 49.47 µM 1.23299239201253 0.141625285737992 no 480 0.10878930132424 569 2377234 SGTC_1271 0832-2808 169 µM 1.22975293668475 0.142304340270061 no 481 0.109394818457854 617 3663794 SGTC_70 0141-0289 43.283 µM 1.22835171941173 0.142598744789602 no 482 0.109657481844725 815 352408 SGTC_1145 3546-0597 10.2 µM 1.22623688942097 0.143043863217498 no 483 0.110054771494845 623 875334 SGTC_3201 9113999 49.47 µM 1.22326154759024 0.14367168559241 no 484 0.110615462824499 593 16649224 SGTC_2284 7945075 39.21 µM 1.22236145986743 0.143861977551786 no 485 0.110785483444708 673 1245402 SGTC_1274 0865-0114 173 µM 1.21906234172625 0.144560913536398 no 486 0.111410265825582 601 870624 SGTC_1623 st003709 20.3 µM 1.2185551090708 0.144668576077175 no 487 0.111506548067907 682 16192618 SGTC_2183 6420625 130.508 µM 1.21719216484178 0.144958134944368 no 488 0.111765555283164 674 2897619 SGTC_1431 4049-0260 9.09 µM 1.21680267948989 0.145040953127979 no 489 0.111839650157983 612 3854841 SGTC_3194 9111903 49.47 µM 1.21648932546246 0.145107606248796 no 490 0.111899287465931 592 17087251 SGTC_614 0462-0418 107 µM 1.21635579377211 0.145136015861192 no 491 0.111924708027978 542 5188303 SGTC_1973 st070275 50.2 µM 1.21300830298886 0.145849436394545 no 492 0.112563323031048 563 17118334 SGTC_2882 9058044 58.44 µM 1.21282385466406 0.145888814595676 no 493 0.112598586519325 575 18076804 SGTC_1947 st076332 61.6 µM 1.21188149182291 0.146090112810457 no 494 0.112778873940937 550 24208416 SGTC_2862 9027634 71.43 µM 1.20589281412452 0.147373714071647 no 495 0.113929410858459 576 5012562 SGTC_2607 solasodine 47.35 µM 1.20412433130477 0.147754208287088 no 496 0.114270763468325 630 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_139 0099-0334 718.624 µM 1.2023605763267 0.148134339940702 no 497 0.114611928269726 710 97690 SGTC_295 k015-0027 31 µM 1.20156312295914 0.148306424982394 no 498 0.114766418165433 617 3887424 SGTC_26 0302-0163 425.158 µM 1.19696756659256 0.149300720045222 no 499 0.115659598298385 622 3100915 SGTC_870 0573-2213 57.6 µM 1.19480975089844 0.149769117320204 no 500 0.116080684869431 604 3916321 SGTC_2920 7982904 15.77 µM 1.19382788841378 0.149982574465427 no 501 0.116272650053958 557 6456808 SGTC_2224 6650123 117.647 µM 1.1932328491843 0.150112034814181 no 502 0.11638909649546 581 2908370 SGTC_677 0929-0063 136 µM 1.19166069738845 0.150454440030764 no 503 0.116697157363595 552 1539583 SGTC_1672 st016598 6.51 µM 1.18823604616929 0.151202108372243 no 504 0.117370213015167 631 4665860 YNL267W PIK1 SGTC_1844 rapamycin 4 nM 1.18674463982142 0.151528482813877 no 505 0.117664180645059 740 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2323 6148992 148.28 µM 1.1833585598022 0.152271218997404 no 506 0.118333536746488 567 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_841 0251-0215 91.2 µM 1.18277659594166 0.15239911567111 no 507 0.118448849193652 694 3888614 SGTC_124 0136-0217 7.121 µM 1.18081617377332 0.152830477003744 no 508 0.118837878743256 729 3976905 SGTC_1381 2324-0066 62.1 µM 1.17981106230732 0.153051950301448 no 509 0.11903768438258 618 10885928 SGTC_2603 homopterocarpin 100 µM 1.17871491955847 0.153293724472753 no 510 0.119255856349256 649 101795 A weak amylase inhibitor. SGTC_3091 9116372 49.47 µM 1.17766227835147 0.153526141649152 no 511 0.119465635437724 583 17169793 SGTC_1240 0356-0016 42.1 µM 1.17438811694673 0.154250548930888 no 512 0.12011980138468 650 4305613 SGTC_1333 1482-0047 286 µM 1.17391523474986 0.154355360496455 no 513 0.120214489802953 682 3811116 SGTC_404 fumagillin 50 µM 1.17389900796742 0.154358957903078 no 514 0.120217739934972 663 12015870 A methionine aminopeptidase binder. SGTC_1091 telmisartan 47.6 µM 1.17379347170565 0.154382356182964 no 515 0.12023887975732 638 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3314 9135860 59.4275 µM 1.17364973781079 0.154414226972036 no 516 0.120267675106926 669 25252478 SGTC_3244 9134489 49.47 µM 1.17284138565049 0.154593547695597 no 517 0.120429709190981 629 16584271 SGTC_3149 9097855 49.47 µM 1.17273550210546 0.154617046551944 no 518 0.120450944917115 620 25236625 YMR079W SEC14 SGTC_1057 3448-5381 134 µM 1.17265583518161 0.154634728679677 no 519 0.120466924444952 647 5497911 SGTC_849 0386-0493 241 µM 1.17259004344648 0.154649332207309 no 520 0.120480122024067 608 726119 SGTC_1357 1503-1303 39.5 µM 1.17076841973886 0.155054032662236 no 521 0.120845937461484 683 292895 SGTC_3144 9087057 49.47 µM 1.17010662435617 0.155201233245941 no 522 0.120979031494771 627 17249618 SGTC_3159 9100096 49.47 µM 1.16806468253494 0.155655995692628 no 523 0.121390337470994 628 25236875 SGTC_2865 9030313 51.95 µM 1.168031743575 0.155663338749391 no 524 0.121396980375561 589 42562754 SGTC_1622 st003707 19.4 µM 1.16498271208903 0.15634404634846 no 525 0.122012995381685 686 10140899 SGTC_3241 9133421 49.47 µM 1.16261008599746 0.156875098336414 no 526 0.122493868379252 616 17018221 SGTC_277 nystatin 15.5 µM 1.16221467408472 0.15696371647854 no 527 0.122574137759963 672 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3028 9087778 49.47 µM 1.16197924249928 0.157016496105705 no 528 0.122621948349861 624 17217395 SGTC_2937 9044753 11.33 µM 1.16190559077176 0.15703300992665 no 529 0.12263690796095 688 6465530 YGL099W LSG1 SGTC_2423 st077119 87.2 µM 1.16183683477391 0.157048427082633 no 530 0.122650874341936 653 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2265 7929201 200 µM 1.16004157784966 0.157451329867133 no 531 0.123015939194878 636 1265108 SGTC_1504 k297-0033 30 µM 1.15838446603639 0.157823831664707 no 532 0.123353587752939 534 4388117 SGTC_3115 9123671 49.47 µM 1.15719106311186 0.158092454650601 no 533 0.12359715409046 670 3286988 SGTC_1817 st052116 64.4 µM 1.15302439228723 0.159032682044008 no 534 0.124450186387655 632 4361398 SGTC_3331 9141060 1.957 µM 1.15273759667063 0.159097533215125 no 535 0.124509052406762 616 4906567 YPR165W RHO1 SGTC_1981 st071826 47 µM 1.15027796060717 0.159654425558811 no 536 0.125014702615485 621 11838600 SGTC_589 1227-0070 34.1 µM 1.14936634580495 0.159861150155501 no 537 0.125202475565602 677 2841384 SGTC_1810 st050138 53 µM 1.14903701354826 0.159935875036826 no 538 0.125270359293504 622 3444541 SGTC_2540 epiandrosterone 100 µM 1.14393658839963 0.161096068144033 no 539 0.126324967905224 799 441302 A steroid. SGTC_2006 4011487 200 µM 1.14349243712978 0.161197358476903 no 540 0.126417096486905 697 45595294 SGTC_2489 cantharidin 73.42 µM 1.14296108868078 0.161318589021871 no 541 0.126527373530049 670 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2109 5483026 200 µM 1.13814613546188 0.162419861618912 no 542 0.127529733125446 694 759335 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.13593810069966 0.162926514258951 no 543 0.12799123554105 682 97141 SGTC_2062 5245942 200 µM 1.13430947894337 0.163300873347524 no 544 0.128332377221917 701 1376160 SGTC_2593 nobiletin 86.24 µM 1.13354417751801 0.163476980305162 no 545 0.128492900059739 613 72344 An anti-infammatory. SGTC_1905 st060207 84.5 µM 1.13246357962539 0.163725851509315 no 546 0.128719793925717 682 1948547 SGTC_1785 bathophenanthroline 24 µM 1.13174957391123 0.163890428178008 no 547 0.12886986661734 661 72812 An iron chelator. SGTC_3184 9108758 49.47 µM 1.12986209002387 0.164326005661688 no 548 0.129267170143445 682 902885 SGTC_1859 st055998 20 µM 1.1297090864638 0.164361347380352 no 549 0.129299413593351 706 676301 SGTC_367 0335-0881 7.1 µM 1.12899870877807 0.164525499405983 no 550 0.129449189188245 695 23828853 SGTC_1515 3460-0031 42.1 µM 1.12823759339347 0.164701493617911 no 551 0.129609795640499 593 2876596 SGTC_1564 D-Arginine 115 µM 1.12732314450343 0.16491310468211 no 552 0.129802940171477 658 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3120 9124077 49.47 µM 1.12561911200909 0.165307901478779 no 553 0.130163387440626 690 18774327 YGL155W CDC43 SGTC_1391 3442-0225 151 µM 1.12245219552415 0.166043247960536 no 554 0.130835111195676 635 5227075 SGTC_960 1222-0186 7.7 µM 1.12119141085415 0.1663365848811 no 555 0.131103197501398 713 3126296 SGTC_1409 3909-8004 61.9 µM 1.1204145228633 0.166517503873071 no 556 0.131268579511725 713 2119279 SGTC_2775 cyproheptadine 69.59 µM 1.1197659957421 0.16666862787034 no 557 0.131406746664072 699 2913 A selective serotonin reuptake inhibitor. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.11829305182121 0.167012191502928 no 558 0.131720926735189 671 5355888 SGTC_1117 retinoic acid 1.10837 µM 1.11812497443999 0.167051424501507 no 559 0.131756810689643 750 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3221 9128209 49.47 µM 1.11412715039679 0.167986357052275 no 560 0.132612321252046 659 16460723 SGTC_120 rhodamine 6G 52.259 µM 1.11080441619073 0.168765970526 no 561 0.133326272582656 811 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2116 5511452 16.8835 µM 1.10964602572102 0.169038309506135 no 562 0.133575794873599 709 870744 SGTC_535 2293-4129 48.2 µM 1.1052447144163 0.17007563489094 no 563 0.134526783235787 777 396118 YIL048W NEO1 SGTC_1437 4092-1038 11.6 µM 1.10426931291226 0.170306074014014 no 564 0.134738165174062 744 3977136 SGTC_1354 1498-1681 81 µM 1.10416726800312 0.170330193729791 no 565 0.134760292768627 755 5754243 SGTC_2849 9019321 12.99 µM 1.10338505038735 0.170515154275218 no 566 0.134929993002506 657 16489627 SGTC_182 3448-4371 550.524 µM 1.09729373932676 0.171959882992238 no 567 0.136256503409619 758 3491403 SGTC_420 mitomycin C 81.9 mM 1.09530058508693 0.172434308597284 no 568 0.136692485634668 705 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1443 4112-3303 14 µM 1.09451730735209 0.172620978563676 no 569 0.136864080456497 725 704433 SGTC_1666 st014829 29 µM 1.09411611519827 0.172716640155319 no 570 0.136952027726902 736 3858230 SGTC_1164 k060-0068 93.7 µM 1.0933549473493 0.172898228409391 no 571 0.137118993136462 757 5963676 SGTC_830 4076-0286 57.8 µM 1.09320126751294 0.172934905844753 no 572 0.137152720328943 851 6866659 SGTC_3229 9132204 49.47 µM 1.09241029934274 0.173123757779869 no 573 0.137326399014737 677 17682924 SGTC_545 4218-0007 221 µM 1.09126219674905 0.173398112914588 no 574 0.137578763451714 688 2840508 SGTC_1850 st056238 17 µM 1.08917879220791 0.173896677882652 no 575 0.138037524632262 762 5393177 SGTC_3011 9081274 71.4286 µM 1.08902334347 0.173933913743278 no 576 0.138071795885904 751 6625322 SGTC_798 1287-0182 476 µM 1.08643912467155 0.174553674617564 no 577 0.138642379906951 787 1649755 SGTC_1750 st081859 2.357 µM 1.08588596429308 0.174686518438676 no 578 0.138764723681631 874 5291695 SGTC_1822 st052468 42 µM 1.08580610251624 0.174705702885655 no 579 0.138782392970025 683 2873678 SGTC_2704 st078022 71.1 µM 1.0851034404225 0.174874554475843 no 580 0.138937921867939 728 54697681 SGTC_2836 9010338 19.48 µM 1.08245928357429 0.17551088024579 no 581 0.13952424908163 645 2994051 SGTC_1160 4092-0570 10.5 µM 1.07934518987409 0.176262177409828 no 582 0.140216937409064 733 4994975 SGTC_1559 coumarin 343 70.1 µM 1.07808226785653 0.176567445481838 no 583 0.140498522083569 686 108770 A hepatotoxic, DNA x-linker. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.07376398602932 0.177613766214042 no 584 0.141464237488227 710 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2002 4023503 131 µM 1.07206622421793 0.178026203686016 no 585 0.141845144070662 841 4736863 YCR052W RSC6 SGTC_2070 5230947 200 µM 1.07126647207611 0.178220696620769 no 586 0.142024815348457 768 2835538 SGTC_560 2332-1943 155 µM 1.06818257569307 0.178971927237093 no 587 0.142719081493551 736 21177716 SGTC_1179 1021-1431 9.29 µM 1.06810991723705 0.178989650675933 no 588 0.142735466440461 766 2840958 SGTC_2526 patulin 37.61 µM 1.06765232495256 0.179101295669129 no 589 0.142838685652897 780 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1688 st021091 57.6 µM 1.06710902698741 0.179233908312026 no 590 0.142961303014223 741 3656366 SGTC_2680 butyl paraben 22.24 µM 1.06607826956132 0.179485673747822 no 591 0.143194130935105 719 7184 An antifungal and steroid mimetic. SGTC_1429 4049-0205 9.46 µM 1.06459224490893 0.179849030551644 no 592 0.143530245372333 798 22774478 SGTC_3215 9129942 49.47 µM 1.06322176046319 0.180184545168947 no 593 0.143840698206901 696 17682944 SGTC_828 2074-0507 139 µM 1.05892986199622 0.181237804120122 no 594 0.144815861631523 761 X828 SGTC_906 1165-0455 526 µM 1.05721762716575 0.181659071161879 no 595 0.14520613840833 719 3252859 SGTC_2907 7721985 69.9 µM 1.05570481453415 0.182031783057894 no 596 0.14555154843326 709 3267881 SGTC_39 0986-0283 58.349 µM 1.05484747353713 0.182243218404283 no 597 0.145747544253917 830 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_470 aa-861 153 µM 1.05102717053514 0.183187236794495 no 598 0.146623055545695 772 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1843 st055809 45.5 µM 1.0501464406272 0.183405301974264 no 599 0.146825394879159 705 16413835 SGTC_2923 7992654 58.14 µM 1.04915371466815 0.183651290845251 no 600 0.14705368869868 725 2985126 SGTC_2202 7226349 200 µM 1.04706955215796 0.184168396684584 no 601 0.147533750508633 735 844334 SGTC_1696 st025591 34.7925 µM 1.0468838154416 0.184214524141656 no 602 0.147576583624828 775 2787147 SGTC_801 0866-0028 10.1 µM 1.04638844840065 0.184337583019014 no 603 0.147690861942496 790 6849771 SGTC_1612 st002233 45.4 µM 1.04529058516177 0.18461049599465 no 604 0.147944343833255 740 1035021 SGTC_3079 9117512 49.47 µM 1.04367792446927 0.185011835519037 no 605 0.148317213334323 824 7185044 SGTC_602 3130-1533 38.1 µM 1.04242673000931 0.185323590840326 no 606 0.148606939533391 821 720941 SGTC_3158 9100007 49.47 µM 1.0421870193409 0.185383355836848 no 607 0.148662490021578 676 19297233 SGTC_353 1988-1175 58.3 µM 1.04033240041086 0.185846156311617 no 608 0.149092748057628 698 2788357 SGTC_2012 4023501 200 µM 1.03977874262931 0.185984454501696 no 609 0.149221353668976 693 3477460 SGTC_2699 st077704 54.6 µM 1.03959324467075 0.186030804307965 no 610 0.149264458361271 757 645852 SGTC_2517 totarol 10 µM 1.03888598259756 0.186207591408044 no 611 0.149428883151242 690 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2750 bromebric acid 70.15 µM 1.03865204864285 0.186266088403088 no 612 0.149483294881684 810 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1338 1486-1223 76 µM 1.03678429342489 0.186733543341328 no 613 0.149918198546898 802 3444526 SGTC_1708 st033234 31.827 µM 1.03578268170745 0.186984521921066 no 614 0.150151769391849 822 674664 SGTC_580 1123-0028 41 µM 1.03426921451033 0.187364154256137 no 615 0.150505162328084 848 1677248 YPR107C YTH1 SGTC_8 0354-0001 70 µM 1.03219018986135 0.187886425039334 no 616 0.150991514898386 865 4993152 SGTC_276 colchicine 750 µM 1.0317440892254 0.187998606793574 no 617 0.151096008720016 791 2833 A microtubule depolymerizer. SGTC_2227 7312221 64.1025 µM 1.02867628117206 0.188771193631167 no 618 0.151815909627778 794 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2570 licareol 100 µM 1.02840690832796 0.188839124939755 no 619 0.151879230120624 743 443158 SGTC_792 4534-1957 155 µM 1.0273041810251 0.189117371275165 no 620 0.152138627122983 771 1717904 SGTC_2766 oltipraz 83.91 µM 1.02620159940174 0.189395833146555 no 621 0.152398283819404 739 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_562 3772-2733 112 µM 1.02603166603629 0.189438773003515 no 622 0.152438329074306 856 2876874 YIL048W NEO1 SGTC_3122 9126309 49.47 µM 1.02561666324549 0.189543663760358 no 623 0.152536154948447 792 17591206 SGTC_1857 st056007 79.3 µM 1.02510570402541 0.189672856299073 no 624 0.152656657204088 756 619834 SGTC_1883 5-benzylidenerhodanine 20 µM 1.02355345521523 0.1900656638769 no 625 0.153023119606893 824 1273210 SGTC_2897 9048598 12.99 µM 1.02056856258528 0.190822415911602 no 626 0.153729445111349 736 6467404 SGTC_2336 9001819 198.65 µM 1.01932086663055 0.19113928814242 no 627 0.154025330373768 803 2989602 SGTC_3102 9121669 49.47 µM 1.01913786628454 0.191185791106202 no 628 0.154068759714208 743 41905072 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.01890620936277 0.191244668337768 no 629 0.154123747770418 841 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2869 9037858 32.47 µM 1.01689341231149 0.191756702539201 no 630 0.154602068773641 733 27187042 SGTC_2654 protoveratrine a 100 µM 1.01680414310005 0.191779431102507 no 631 0.154623305401079 775 5702278 A heart drug and vasodilator. SGTC_2250 alverine citrate 130 µM 1.01351427058389 0.192618205750929 no 632 0.155407291639431 840 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2036 5160441 105 µM 1.01251379731617 0.192873726922488 no 633 0.155646226552872 844 134534 YIL048W NEO1 SGTC_2441 5730946 39.09 µM 1.01208233999573 0.192983985120641 no 634 0.155749342738979 791 1774275 SGTC_1657 st012939 43.4 µM 1.01176408659172 0.193065338909179 no 635 0.155825432606227 755 24207257 SGTC_1163 k060-0048 49.9 µM 1.01159913090777 0.193107514079983 no 636 0.155864880808787 816 6809982 SGTC_90 0870-0863 4.608 µM 1.01102596110478 0.193254103430629 no 637 0.156002002247528 821 1738164 SGTC_3325 9138760 55.175 µM 1.01097345474277 0.19326753543507 no 638 0.15601456750429 762 43844959 SGTC_2883 9059145 45.46 µM 1.00845491618247 0.193912488618684 no 639 0.156618060346307 742 16476510 SGTC_657 3534-0529 86.7 µM 1.00691539033174 0.194307379140302 no 640 0.156987717713922 819 1049549 SGTC_1778 st046819 58.9 µM 1.00623178724442 0.194482881157823 no 641 0.157152042313887 844 671715 SGTC_2591 skatole 100 µM 1.00616953076348 0.194498869110735 no 642 0.15716701315263 775 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_922 1866-0035 480 µM 1.00606166309006 0.194526572269564 no 643 0.157192954351617 898 3156169 SGTC_1238 0333-0287 48.8 µM 1.00597470028789 0.194548908274777 no 644 0.15721387016809 777 7226 SGTC_2243 6634756 200 µM 1.00452357275211 0.194921854152462 no 645 0.157563157435215 760 885676 SGTC_2733 amorolfine 100 µM 1.00313101040571 0.19528015699892 no 646 0.157898827120042 738 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_989 1501-0895 10.3 µM 1.00164301649902 0.195663456087598 no 647 0.15825801863902 813 2830112 SGTC_876 0720-0963 56.8 µM 1.00007020825523 0.196069099031557 no 648 0.158638266185434 840 765861 SGTC_517 1365-0151 113 µM 0.999953486258511 0.196099223117633 no 649 0.15866650915694 795 768657 SGTC_3198 9112019 49.47 µM 0.999300776176537 0.196267728913274 no 650 0.158824504778049 787 45595555 SGTC_2416 tofa 880 nM 0.995616107149563 0.197220620785187 no 651 0.159718352812421 721 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1655 st012546 55.1 µM 0.993522496259299 0.197763294061954 no 652 0.160227696479574 783 720985 YLR208W SEC13 SGTC_2031 5180455 200 µM 0.992482997868135 0.198033071568184 no 653 0.160480984635775 776 29949 SGTC_2529 gangaleoidin 93.61 µM 0.987907841612464 0.199223085705677 no 654 0.16159889234063 828 4565183 SGTC_519 k048-0011 62.8 µM 0.984519342153689 0.20010721619397 no 655 0.162430112999827 805 6836379 SGTC_2400 5203494 178.7 µM 0.983719463419772 0.200316264880677 no 656 0.162626733622743 750 6777674 SGTC_2035 5154463 94.595 µM 0.983155086622362 0.200463843944544 no 657 0.162765557927402 820 2769623 SGTC_2414 st077232 92.9 µM 0.982107634400279 0.20073791555724 no 658 0.163023412385351 755 729801 SGTC_662 k832-1615 104 µM 0.981718892098701 0.200839689309286 no 659 0.163119177770789 798 5878478 SGTC_1527 coumarin 137 µM 0.979145549014245 0.201514177843114 no 660 0.163754034233388 766 323 A hepatotoxic, DNA x-linker. SGTC_3280 9140961 49.47 µM 0.978177403692471 0.20176828545303 no 661 0.163993295118069 784 4901226 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.976387723275747 0.202238525023756 no 662 0.164436181472609 840 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_176 1486-1328 72.834 µM 0.97442874998919 0.202753997229157 no 663 0.164921850134904 831 22310231 SGTC_3186 9110464 49.47 µM 0.973763735961976 0.202929163263769 no 664 0.165086931397716 799 17018021 SGTC_3114 9122766 49.47 µM 0.973364894183847 0.203034262338161 no 665 0.165185990089509 756 17176985 SGTC_2878 9043973 25.97 µM 0.971194774163084 0.203606681484194 no 666 0.165725647855634 803 6465167 SGTC_2955 9076254 12.21 µM 0.969618717682944 0.204023005325077 no 667 0.166118289732615 773 16459619 SGTC_995 3931-2021 34.6 µM 0.96883036411782 0.204231443337302 no 668 0.166314917028115 809 730143 SGTC_2728 chlorpromazine 9.18 µM 0.966169414719787 0.204935925122963 no 669 0.16697970734938 741 2726 A thorazine and dopamine antagonist. SGTC_2019 4016004 108 µM 0.966115661098697 0.204950171173302 no 670 0.16699315435968 763 45595336 SGTC_3020 9089140 49.47 µM 0.965274255416854 0.205173241391615 no 671 0.167203731492475 818 17217859 SGTC_880 0833-0487 87.2 µM 0.965188930672896 0.205195870411565 no 672 0.167225095122543 811 76075 SGTC_2485 5633444 17.78 µM 0.96490811422385 0.205270356359899 no 673 0.167295418437331 796 5724239 SGTC_2970 9090938 41.86 µM 0.963092923585482 0.205752219067252 no 674 0.167750446336061 900 17217104 SGTC_850 0388-0143 75.9 µM 0.961488925084623 0.206178576582527 no 675 0.168153195683235 786 67273 SGTC_1080 nisoldipine 24.4 µM 0.959165992877731 0.206796960930023 no 676 0.168737564654821 851 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1659 st012954 42.1 µM 0.958260206053834 0.207038386330324 no 677 0.168965782365586 834 24207262 SGTC_1990 st072050 59.8 µM 0.957840889951485 0.207150205891508 no 678 0.169071498348996 847 17233948 SGTC_551 k048-0028 34.9 µM 0.956792121821382 0.207430038593296 no 679 0.169336094726658 901 6836383 SGTC_2132 5317594 122.667 µM 0.955911192764218 0.207665260997084 no 680 0.169558551835811 785 794577 SGTC_2165 5727197 32.143 µM 0.955471773550543 0.207782651968681 no 681 0.169669586478251 787 1361712 SGTC_1227 3909-8010 46.6 µM 0.953295318740054 0.208364670090861 no 682 0.170220231341988 825 15982272 SGTC_2086 5274770 176.623 µM 0.952384506240586 0.208608520761951 no 683 0.170451007117861 834 689278 SGTC_2683 piperine 63.03 µM 0.951112653125193 0.208949313713885 no 684 0.170773596110036 823 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2383 9036125 200 µM 0.949755491561457 0.209313326488245 no 685 0.171118253106279 828 79580 SGTC_1845 st056753 3.01 µM 0.94912486145826 0.20948259865262 no 686 0.17127855560129 854 5375839 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.947995808376473 0.209785857359101 no 687 0.171565794045438 851 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2932 9016711 44.54 µM 0.947209282930143 0.209997267083915 no 688 0.171766073016061 905 7117328 SGTC_615 k087-0205 167 µM 0.94683791531445 0.210097130266239 no 689 0.171860689060767 802 9642773 SGTC_948 3448-0295 75.3 µM 0.946816553743543 0.210102875380873 no 690 0.171866132516566 881 678569 SGTC_68 0986-0284 82.829 µM 0.946192145886728 0.210270848312068 no 691 0.172025295701228 698 423278 YIL048W NEO1 SGTC_690 glyoxal 20.3 µM 0.942673887980661 0.211218773290596 no 692 0.172923866753951 834 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_410 α-linolenic acid 100 µM 0.942102234706396 0.211373030079207 no 693 0.173070150248128 889 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_571 k831-0106 44.2 µM 0.941980248886849 0.211405955672155 no 694 0.173101376071381 816 4783639 SGTC_469 w7 172 µM 0.941913976986258 0.211423844597525 no 695 0.173118341798719 850 45115570 A P450 inhibitor. SGTC_1132 3456-3614 2.5 µM 0.940804516019067 0.211723455553813 no 696 0.173402523096422 954 3125502 SGTC_825 1988-2224 89.6 µM 0.939716212289036 0.212017594254358 no 697 0.17368157344795 863 1180859 SGTC_1767 st044992 70.3 µM 0.938685732331825 0.212296324918985 no 698 0.173946060468632 844 9600693 SGTC_2138 5575593 77.673 µM 0.938500073903646 0.21234656573042 no 699 0.173993739500871 855 762213 SGTC_1340 1486-1359 257 µM 0.933184956511559 0.213787827750378 no 700 0.175362240271277 873 4309068 SGTC_1759 st043059 70 µM 0.932713907317365 0.213915832998622 no 701 0.175483851180459 873 669426 SGTC_3098 9119039 49.47 µM 0.932587841991779 0.21395009818401 no 702 0.175516406567952 882 17161528 SGTC_1835 st008666 49.2 µM 0.931752950459887 0.214177106512573 no 703 0.175732107409244 767 690455 SGTC_2939 9044578 71.43 µM 0.930918404466185 0.214404160884724 no 704 0.175947886735501 838 2653634 SGTC_1269 0831-0796 3.05 µM 0.93061335210216 0.214487191199759 no 705 0.176026802605901 893 927758 SGTC_1021 4476-0760 85.3 µM 0.929982787371964 0.214658879960619 no 706 0.17618999829548 826 746768 SGTC_85 0868-0259 160.055 µM 0.929321965787035 0.214838892673487 no 707 0.176361127453285 826 83173 SGTC_1950 st077106 7.18 µM 0.928780600471013 0.214986429938473 no 708 0.176501400047839 881 13831864 SGTC_738 1315-0003 72.4 µM 0.927910300358259 0.215223734464182 no 709 0.176727050455783 898 6251474 SGTC_1900 st060200 72.8 µM 0.923458435338759 0.216439998928839 no 710 0.177884175696066 883 688945 SGTC_3306 9127676 59.7925 µM 0.92305108493102 0.216551486708191 no 711 0.17799029198492 853 41905287 SGTC_47 0149-0135 24.25 µM 0.922084643299167 0.216816125107688 no 712 0.178242213259092 906 5239155 SGTC_1539 benzyladenosine 56 µM 0.918649725153631 0.217758212494989 no 713 0.179139407056683 870 92208 A nucleotide analog. SGTC_232 clozapine 119 µM 0.918578154757762 0.217777867029872 no 714 0.179158131264163 880 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_921 1561-0023 372 µM 0.918395244034319 0.21782810229685 no 715 0.179205989859942 894 24050882 SGTC_2242 6630449 61.2675 µM 0.915063979770843 0.218744181473793 no 716 0.180079021651784 786 691249 YDR170C SEC7 SGTC_1257 0669-0121 16 µM 0.914627548724395 0.218864361634574 no 717 0.180193595602573 983 4307855 SGTC_596 1155-0152 116 µM 0.914282821544583 0.218959316119056 no 718 0.180284127354955 923 280313 SGTC_1638 st008370 60.6 µM 0.914170720699416 0.218990199201096 no 719 0.180313573265563 862 24207134 SGTC_722 3534-0461 190 µM 0.913540371240881 0.219163903181 no 720 0.180479205495179 914 658262 SGTC_2082 5219693 150 µM 0.911633566598952 0.219689839012218 no 721 0.180980823112665 898 2834649 SGTC_2399 5884133 200 µM 0.909983433686271 0.220145563863737 no 722 0.181415623263557 865 722445 SGTC_418 lividomycin a 100 µM 0.909721659744441 0.220217908982761 no 723 0.18148465918376 958 72394 An antibiotic. SGTC_2936 9038235 15.59 µM 0.909567184617923 0.220260606875098 no 724 0.181525405607269 889 4749415 SGTC_2045 5106652 78.05 µM 0.908817922639272 0.220467774915216 no 725 0.181723122190322 914 673349 SGTC_208 k072-0098 12.366 µM 0.908769855154642 0.220481069199528 no 726 0.181735810921032 994 5948901 SGTC_3303 9125618 40.5795 µM 0.907069383588076 0.220951673335595 no 727 0.182185053636961 948 22695467 SGTC_1940 st075990 51.1 µM 0.90696109144697 0.220981662560029 no 728 0.182213686517641 944 1084979 SGTC_1943 st076331 65.2 µM 0.906302081466372 0.221164211695231 no 729 0.182387992055888 938 24208415 SGTC_1613 st002381 52.1 µM 0.905858812339195 0.221287048027769 no 730 0.182505293571142 965 551167 SGTC_2778 tioconazole 65.09 nM 0.904019781337085 0.221797086876717 no 731 0.182992456176079 856 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.903878795319505 0.221836215785942 no 732 0.183029837081659 891 7104 SGTC_1720 st037298 9.481 µM 0.903739958516059 0.221874752060462 no 733 0.183066652802075 859 597396 SGTC_2868 9035608 32.47 µM 0.903242277503158 0.222012922436322 no 734 0.183198662145049 905 6462614 SGTC_126 0417-1624 672.48 µM 0.902213658603641 0.222298651876285 no 735 0.183471690286928 1067 41912 YDL195W SEC31 SGTC_1279 0874-0590 65.2 µM 0.899970014142259 0.222922618088115 no 736 0.184068104248873 914 3523074 SGTC_963 1269-2853 151 µM 0.898582127533355 0.223309093656988 no 737 0.184437640989759 883 3668223 SGTC_2361 9034121 116 µM 0.896820344510584 0.223800234474245 no 738 0.18490739507902 884 6496917 SGTC_701 4424-0219 185 µM 0.895839352811734 0.224073976211911 no 739 0.185169284369153 975 2911779 SGTC_3285 9112818 20.8695 µM 0.895510977052969 0.22416565060015 no 740 0.185257000255225 951 17017947 YPR165W RHO1 SGTC_3005 9076496 71.4286 µM 0.892797138480359 0.224924102125578 no 741 0.185982909518193 909 21368410 SGTC_2455 5377712 9.75 µM 0.892418397399999 0.225030066541879 no 742 0.186084356869566 816 2243908 SGTC_2429 5902844 64.44 µM 0.89202393952791 0.22514045828054 no 743 0.186190050486783 960 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1737 st035557 69.7 µM 0.891780598139903 0.225208574333824 no 744 0.18625527151816 786 5716916 SGTC_2802 7925815 54.55 µM 0.891090550366572 0.225401795785552 no 745 0.186440297008851 906 1262923 SGTC_1842 st055362 61.2 µM 0.888932423861298 0.226006701865279 no 746 0.187019699258756 972 676032 SGTC_2702 st077768 96.8 µM 0.888026656540627 0.226260854552055 no 747 0.18726320632596 820 6484119 SGTC_2405 ticlatone 3.52 µM 0.88764600941922 0.226367709937516 no 748 0.1873655982194 962 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_300 r073-0011 5.04 µM 0.887363683003997 0.226446983108178 no 749 0.187441564756531 991 2735780 SGTC_3146 9095609 49.47 µM 0.88512258221162 0.227076807599962 no 750 0.188045260555004 923 17173999 SGTC_2333 9017922 200 µM 0.883009300808336 0.227671614219536 no 751 0.188615623165633 940 3163164 SGTC_1113 artemisinin 1.17947 µM 0.882553485741503 0.227800023350752 no 752 0.188738784744522 963 2240 An anti-malaria and mitochondrial poison. SGTC_970 1315-0089 19.5 µM 0.881968820885312 0.227964790823768 no 753 0.188896834182073 890 6811083 YLR033W RSC58 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.881757504546914 0.228024359480737 no 754 0.188953978296048 959 165506 SGTC_333 3486-0131 40.1 µM 0.880495026800127 0.228380425820949 no 755 0.189295599057995 977 6744690 SGTC_98 0074-0023 107.663 µM 0.880218785256455 0.228458377996683 no 756 0.189370399438079 974 3563821 SGTC_78 0336-0123 156.75 µM 0.880171288784514 0.228471782458882 no 757 0.189383262312993 852 6765896 SGTC_1964 st076914 61 µM 0.879965568021675 0.228529846108022 no 758 0.189438981300413 982 24208661 SGTC_2273 7815444 169.05 µM 0.879466643607967 0.228670699434149 no 759 0.189574155708957 932 2824616 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.878422360025966 0.228965673008135 no 760 0.189857277199196 972 165521 SGTC_468 gf-109203x 121 µM 0.877959670898543 0.229096434721735 no 761 0.189982802474163 838 2396 A protein kinase C inhibitor. SGTC_1949 st076024 69.1 µM 0.877549009488851 0.229212527833763 no 762 0.190094255608042 978 2921930 SGTC_2826 7992541 19.48 µM 0.877213491899297 0.229307402428618 no 763 0.190185344596069 945 2985066 SGTC_1721 st082152 9.2685 µM 0.877169711816498 0.229319783783553 no 764 0.190197232339398 902 5296051 SGTC_2962 9082311 13.18 µM 0.877000644347847 0.229367600923795 no 765 0.190243144045514 904 16459453 SGTC_1137 ixabepilone 100 µM 0.876469975275971 0.229517725689461 no 766 0.190387295955285 932 154225 A novel microtubule stabilizer. SGTC_2952 9073731 13.78 µM 0.872562211197015 0.230624914911256 no 767 0.191450872664502 985 16457353 SGTC_1304 1165-0502 251 µM 0.872277375074604 0.230705734231995 no 768 0.191528538644534 955 767425 SGTC_2656 pseudo-anisatin 100 µM 0.871149795428419 0.231025828602819 no 769 0.191836184061212 959 6708809 A neurotoxin. SGTC_2709 st078560 56 µM 0.8707187297256 0.231148263879514 no 770 0.191953874613461 960 17250903 SGTC_2954 9074818 52.69 µM 0.869922659328521 0.231374466318297 no 771 0.192171335722431 916 16648742 SGTC_377 3970-0964 33.1 µM 0.869709783737545 0.231434975572508 no 772 0.192229512092042 1019 16481235 SGTC_1978 st071761 42 µM 0.869065842556801 0.231618067644911 no 773 0.192405559137919 894 5147680 SGTC_598 3937-0236 20.2 µM 0.867907483477646 0.231947627512344 no 774 0.192722490937303 1004 1379313 SGTC_3206 9114350 49.47 µM 0.86754806511175 0.232049937175249 no 775 0.192820894085253 871 17087243 SGTC_2507 purpurin 79.67 µM 0.86697671053469 0.232212626903798 no 776 0.192977385230936 977 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1957 st077035 62.4 µM 0.866760576800399 0.232274186208526 no 777 0.193036603387878 985 705593 SGTC_355 1311-2252 105 µM 0.866705477777581 0.232289880988625 no 778 0.193051701661049 907 5338538 SGTC_1345 1488-0192 31.4 µM 0.866617566787628 0.2323149233741 no 779 0.193075792585587 992 658348 SGTC_2134 5324836 1.464 µM 0.86638336072155 0.232381646806631 no 780 0.193139982833115 885 699272 SGTC_3278 9139605 49.47 µM 0.866300403932793 0.232405283087676 no 781 0.193162722417083 922 7958859 SGTC_1581 himbacine 57.9 µM 0.865812561383373 0.232544307606178 no 782 0.193296479756431 924 5281825 An alkaloid muscarinic receptor antagonist. SGTC_573 3702-0553 84.7 µM 0.864792097549299 0.232835267080922 no 783 0.193576454651144 915 1222756 SGTC_167 3672-0051 66.205 µM 0.863604398218333 0.233174164083746 no 784 0.193902623609923 908 3237971 SGTC_1771 st048882 4.1505 µM 0.859804132898528 0.234260365803489 no 785 0.194948510345634 960 4580403 SGTC_2723 salbutamol 83.58 µM 0.857336714823294 0.234967106620043 no 786 0.195629411660107 892 9884233 β2-adrenoceptor agonist SGTC_2436 5633522 8.09 µM 0.856689805261472 0.23515259520963 no 787 0.195808169511083 994 5724242 SGTC_1681 tripelennamine 100 µM 0.855519450020091 0.235488376950359 no 788 0.196131820743106 916 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2274 7947094 46.08 µM 0.854771061401131 0.235703232612829 no 789 0.19633895085247 1038 2971028 SGTC_527 4476-4215 268 µM 0.852278517633469 0.236419598603851 no 790 0.197029763168513 947 4418754 SGTC_1115 galangin 695.678 nM 0.851098603000914 0.236759127776071 no 791 0.197357290700451 1053 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_369 0957-0393 4.5 µM 0.850429786211966 0.236951703779757 no 792 0.197543090875549 938 6997992 SGTC_67 0335-0847 266 µM 0.849162806631469 0.237316747933228 no 793 0.197895353024333 1046 4552207 YOR254C SEC63 SGTC_2083 5306046 65.942 µM 0.849025966693443 0.237356192942722 no 794 0.197933421736243 965 539837 SGTC_3088 9117578 49.47 µM 0.847976384774753 0.237658861485679 no 795 0.19822556126388 1000 678341 SGTC_1152 3909-8331 15.9 µM 0.847830499229218 0.237700947340294 no 796 0.198266187485979 936 16001939 SGTC_292 k038-0015 474 µM 0.846953898403128 0.237953919984011 no 797 0.198510409185859 975 46368540 SGTC_2610 ononetin 44.17 µM 0.844151269423598 0.238763702248701 no 798 0.199292440641498 952 259632 SGTC_285 1486-1325 46 µM 0.84319324561498 0.23904085580929 no 799 0.199560187679523 986 22310230 SGTC_3067 9117431 49.47 µM 0.842536132522298 0.239231058396151 no 800 0.199743961756045 950 17150885 SGTC_1045 1348-1485 165 µM 0.841360135476791 0.239571659214039 no 801 0.200073105555596 1093 6810614 SGTC_2253 7938677 135.83 µM 0.841340884704632 0.239577236963995 no 802 0.200078496266657 998 2301972 SGTC_2777 climbazole 1.536 µM 0.841043158468515 0.239663509672271 no 803 0.200161878382718 1005 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2784 7567673 72.73 µM 0.839641570606691 0.240069878201861 no 804 0.200554691848668 1016 3471247 SGTC_2624 nerol 100 µM 0.838096526248067 0.240518274638754 no 805 0.2009882468637 968 637566 A natural product oil. SGTC_2804 7954240 19.48 µM 0.837313694807785 0.240745638719483 no 806 0.201208131698623 990 828705 SGTC_869 0564-0080 44.1 µM 0.837151678153385 0.240792709133974 no 807 0.201253657595023 947 6843321 SGTC_563 tetrahydrosecaminediol 614 µM 0.836705066013825 0.240922488499969 no 808 0.201379185418564 1033 334274 A psychoactive constituent of the cannabis plant. SGTC_2267 7931562 200 µM 0.835865565237025 0.241166538858342 no 809 0.20161526814875 889 934880 SGTC_1621 st003705 32.4 µM 0.835680060331173 0.241220484910546 no 810 0.201667457824742 1041 24207032 SGTC_980 1473-0395 201 µM 0.833346578253313 0.241899636728317 no 811 0.202324647084018 927 768876 SGTC_2727 riluzole 51.77 µM 0.833270466843451 0.241921806144916 no 812 0.20234610423794 982 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2942 9052777 62.25 µM 0.832395020229589 0.242176881845012 no 813 0.202593005976935 1052 6469503 SGTC_1126 isoteolin 1.0172 µM 0.829703624977819 0.242961976203584 no 814 0.203353185716091 992 133323 SGTC_782 0083-0095 30.5 µM 0.829522535669235 0.243014850313185 no 815 0.203404395103446 1052 3591729 An indicator and reagent. SGTC_638 3970-0837 4.09 µM 0.828555849434625 0.243297206769468 no 816 0.20367788985535 979 4118451 YLR208W SEC13 SGTC_210 3551-0445 56.827 µM 0.828507611154854 0.243311301185914 no 817 0.203691543164826 998 2865180 YOR207C RET1 SGTC_153 4077-0274 519.67 µM 0.828269120431229 0.243380990659795 no 818 0.203759053333846 970 3121976 SGTC_501 nsc-95397 161 µM 0.825381931533037 0.244225512356149 no 819 0.204577394840968 981 262093 SGTC_1465 k213-0056 144 µM 0.824074774590832 0.244608383261431 no 820 0.204948536121607 948 24048857 YMR208W ERG12 SGTC_900 1112-0045 141 µM 0.823874571280671 0.244667052054577 no 821 0.205005415208745 903 56211 YIL048W NEO1 SGTC_2888 9058547 12.99 µM 0.820768183642256 0.245578336873668 no 822 0.205889162287516 915 16476514 SGTC_1109 tnp00067 928.257 nM 0.820128882911439 0.245766107052268 no 823 0.206071319211318 979 676295 SGTC_187 1488-2104 32.728 µM 0.818514329895471 0.246240663287664 no 824 0.206531781477232 1060 2852859 SGTC_2131 toluylene red 5.2905 µM 0.816539955383254 0.246821646876335 no 825 0.207095690551662 980 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1084 voriconazole 435 nM 0.81533131689038 0.247177665145252 no 826 0.207441343681697 1054 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.812452335662597 0.248026806954128 no 827 0.208266063049284 1018 279621 SGTC_1965 Pectolinarigenin 58.4 µM 0.808691406829 0.249138415372984 no 828 0.209346336109314 1060 5320438 An anti-inflammatory. SGTC_668 1682-0499 62.6 µM 0.808299873049053 0.249254292149139 no 829 0.209458987798278 1047 682214 SGTC_347 4534-1311 26.2 µM 0.807984614866099 0.249347615527105 no 830 0.209549719466861 1035 2862016 SGTC_2821 7996764 71.43 µM 0.806993304690521 0.249641186201349 no 831 0.209835170276948 1091 2987135 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.806068011693337 0.249915371845207 no 832 0.210101817372358 1022 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1187 1391-0724 117 µM 0.805513064599324 0.250079892105662 no 833 0.210261835170864 1040 6997986 SGTC_2701 st077767 14.721 µM 0.805266760831684 0.250152930012409 no 834 0.210332879256736 1052 5721188 SGTC_1772 st048439 82.2 µM 0.802980071270292 0.250831555309031 no 835 0.210993126647946 1005 2927068 YDL195W SEC31 SGTC_2332 7982454 138.89 µM 0.802338297046791 0.251022190892702 no 836 0.211178647473481 1020 2981748 SGTC_1914 st062367 72.6 µM 0.799020021551729 0.25200908843826 no 837 0.212139401328382 983 978205 SGTC_2117 5521686 200 µM 0.798805883452938 0.2520728460938 no 838 0.212201489260586 1022 803312 SGTC_2089 5281248 129.67 µM 0.798525046726545 0.252156475550884 no 839 0.212282932119655 1008 2737878 SGTC_1043 0916-0009 19.3 µM 0.79715231383432 0.252565467717358 no 840 0.212681288487819 1129 3101130 SGTC_100 0086-0128 49.5915 µM 0.79686633874408 0.25265071512812 no 841 0.212764331130443 1065 93297 SGTC_3204 9114183 49.47 µM 0.796812592935366 0.252666738113807 no 842 0.212779940175946 995 17027248 SGTC_3140 9094243 49.47 µM 0.795740722805817 0.252986401461045 no 843 0.213091376025888 1124 19291112 SGTC_661 1304-0007 33.6 µM 0.795144407473043 0.253164332399748 no 844 0.21326475271708 1004 3117130 SGTC_59 0330-0160 1.33 µM 0.794078759178345 0.253482468602774 no 845 0.213574791155761 1106 4293482 SGTC_2464 5717415 7.67 µM 0.793367507880564 0.253694920772779 no 846 0.213781867815732 1023 5285744 SGTC_1476 4112-3294 3.34 µM 0.792860711608092 0.253846358855091 no 847 0.213929489905506 1058 704369 SGTC_432 NS 1619 61.3 µM 0.791535816185162 0.254242480901692 no 848 0.214315692158648 977 4552 A K+/calcium channel activator. SGTC_2715 st079500 56.4 µM 0.790364386172538 0.254592989082627 no 849 0.214657497339663 997 28246688 SGTC_2714 st079313 56.9 µM 0.790155635835531 0.254655476652898 no 850 0.214718440705362 1035 2939799 SGTC_1841 st054148 70 µM 0.788948613189399 0.255016945656329 no 851 0.215071020564917 974 675442 SGTC_1213 1315-0166 115 µM 0.786565612488215 0.255731374031445 no 852 0.215768098008138 952 768401 SGTC_2000 st075254 36.4 µM 0.786363606504119 0.255791983838782 no 853 0.215827249126435 1020 17234175 SGTC_1647 st011722 22.4 µM 0.785943210132097 0.255918143461394 no 854 0.215950379147935 1031 2854783 SGTC_2951 9072950 58.06 µM 0.783716991602039 0.256586765451818 no 855 0.216603095032814 1133 16488155 SGTC_2774 tamoxifen 10.92 µM 0.781885502624245 0.257137515806343 no 856 0.217140932861205 1107 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_25 0118-0223 35.662 µM 0.7811177588104 0.257368568149568 no 857 0.217366618975616 1068 5333628 SGTC_1423 4048-0112 5.59 µM 0.779693207190112 0.257797572303346 no 858 0.217785739055437 1088 X1423 SGTC_2565 isoliquiritigenin 100 µM 0.777946427467235 0.258324121656984 no 859 0.218300298185668 971 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2304 7443016 91.4 µM 0.777661201845225 0.258410152981338 no 860 0.218384385238181 999 939854 SGTC_951 1171-0579 82.7 µM 0.776733148551389 0.258690180220796 no 861 0.218658112683952 1112 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1318 1280-3875 124 µM 0.775857283930865 0.25895460426017 no 862 0.218916628237067 1062 373245 SGTC_2364 9055074 200 µM 0.771732958618075 0.260201617010902 no 863 0.220136302936564 1072 6470630 SGTC_352 k048-0007 5.11 µM 0.771126434897643 0.260385263525126 no 864 0.220315996578218 1103 6811911 SGTC_2677 mitomycin C 100 µM 0.771019783171472 0.260417563009204 no 865 0.220347602775789 1082 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_888 0916-0002 6.97 µM 0.770662961501063 0.260525641481146 no 866 0.220453365632638 1096 2802138 YIL048W NEO1 SGTC_1868 st057644 42.7 µM 0.770620662433512 0.260538455066361 no 867 0.220465905113147 1115 688665 SGTC_2905 7799065 20.05 µM 0.770521910717515 0.260568371020176 no 868 0.220495181468146 1048 1296806 SGTC_1417 3966-0327 90.4 µM 0.769834079468429 0.260776792423723 no 869 0.220699160645547 1119 651118 SGTC_1157 4092-0394 27.6 µM 0.76742225274487 0.261508282927155 no 870 0.221415251073274 1137 3659885 SGTC_3256 9138902 49.47 µM 0.766465525226311 0.261798743366444 no 871 0.221699678637249 1119 17228773 SGTC_1547 harmine 94.2 µM 0.76570207146235 0.262030644967344 no 872 0.221926797119269 1158 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1308 1187-1617 41.4 µM 0.76542627538672 0.262114444818605 no 873 0.222008875852658 1112 2882570 SGTC_2326 6164455 177.58 µM 0.762902193795675 0.262882017339596 no 874 0.222760863890623 1044 2888790 SGTC_3057 9095946 49.47 µM 0.762335240920857 0.26305458548918 no 875 0.222929972978019 1140 24540043 SGTC_1155 4088-0394 48.2 µM 0.762290865247144 0.263068094923689 no 876 0.222943212312736 1091 2326248 SGTC_574 1315-0397 40 µM 0.758346248040797 0.2642703827806 no 877 0.224121863775096 1166 6794277 SGTC_171 k064-0041 9.68 µM 0.75781492785077 0.264432538490493 no 878 0.224280892239372 1022 53325 SGTC_2617 dihydrotanshinone i 20.83 µM 0.757506273714035 0.264526761115269 no 879 0.224373304348713 1138 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2151 5563267 85.4165 µM 0.756816010540585 0.264737539055601 no 880 0.224580049709815 1084 5310824 SGTC_510 ag-490 170 µM 0.75660517850562 0.264801935496366 no 881 0.224643218969013 1199 5328779 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.756458829294531 0.264846641014853 no 882 0.224687073881965 1121 688788 SGTC_2684 capsaicin 100 µM 0.754779383677403 0.265359938330932 no 883 0.225190682959585 1090 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3263 9137018 49.47 µM 0.754558211274905 0.265427573957983 no 884 0.225257052715411 1071 43844957 SGTC_348 k064-0012 10.7 µM 0.7522338433196 0.266138905946361 no 885 0.225955222289703 1074 5066323 SGTC_1198 1612-1005 86.7 µM 0.751608983003912 0.266330297965226 no 886 0.226143119805189 1142 6998509 SGTC_2419 paclitaxel 166.5 µM 0.751118595335531 0.266480550358287 no 887 0.226290642780557 1113 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_595 3909-8003 73.7 µM 0.750319195389463 0.266725574490953 no 888 0.226531242203242 1119 699517 SGTC_3264 9137442 49.47 µM 0.750159368272069 0.266774576768001 no 889 0.226579363492875 1086 17015726 SGTC_3161 9100388 49.47 µM 0.748516893442886 0.267278415656451 no 890 0.227074219599129 1147 25236368 SGTC_160 3453-0671 289.699 µM 0.74793487876967 0.267457067256085 no 891 0.227249719088158 1131 5322268 SGTC_2305 7443522 69.23 µM 0.747603377117759 0.267558849851437 no 892 0.22734971356203 1102 5415886 SGTC_1745 st081495 74 µM 0.746245521418591 0.267975962733595 no 893 0.227759557074127 1109 13842402 YBL026W LSM2 SGTC_361 000s-0510 1.45 µM 0.745412416711475 0.268232041964506 no 894 0.228011219940887 1097 660 SGTC_1917 st066507 28.5 µM 0.744305643999393 0.268572431431362 no 895 0.228345793763072 1092 3156428 SGTC_1474 0330-0125 5.35 µM 0.744237502034069 0.268593395679122 no 896 0.228366401871962 1139 X1474 SGTC_2769 toremifene 3.73 µM 0.742764891334959 0.269046653246288 no 897 0.228812017385084 1126 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1301 naphtanilide LB 4.81 µM 0.740512521502981 0.269740656113359 no 898 0.229494533122868 1175 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3301 9125354 19.7965 µM 0.740184604130845 0.269841769117033 no 899 0.229593994075369 1085 41905162 SGTC_3243 9134147 49.47 µM 0.740081413582985 0.269873591747258 no 900 0.229625297900212 1191 24282180 SGTC_227 fluconazole 33.516 µM 0.740031128251051 0.269889099773995 no 901 0.229640553295771 1132 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2980 9014342 25.29 µM 0.738383155779008 0.27039758221925 no 902 0.230140823730938 1112 2996599 SGTC_1499 4480-0877 67.3 µM 0.7382114018528 0.27045060448786 no 903 0.230192997654484 1072 2861909 SGTC_1103 duloxetine 36.1 µM 0.737686223007844 0.270612765023475 no 904 0.230352572984354 1198 60835 A selective serotonin reuptake inhibitor. SGTC_2722 naftopidil 47.16 µM 0.737436416880865 0.270689915207216 no 905 0.230428498153611 1131 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_311 1315-0136 58 µM 0.731049202163515 0.272666266839901 no 906 0.232374550189974 1148 6759207 SGTC_123 0083-0120 66.675 µM 0.730584324665361 0.2728103897543 no 907 0.232516544760027 1105 16001701 SGTC_1774 st048371 48.465 µM 0.730029411821306 0.272982475196901 no 908 0.232686103338628 1142 4242727 SGTC_1107 amlodipine 47 µM 0.729685051219609 0.273089292799546 no 909 0.232791360345544 1060 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_743 1275-0778 158 µM 0.729520260905372 0.273140416620309 no 910 0.23284173938936 1143 2849257 YMR203W TOM40 SGTC_1816 st051957 91.6 µM 0.729051207582891 0.273285959612707 no 911 0.232985169671356 1142 674121 SGTC_3228 9131799 49.47 µM 0.728670141199972 0.27340422932962 no 912 0.233101730831608 1084 17015818 SGTC_2963 9082507 9 µM 0.728630780765529 0.273416446879789 no 913 0.233113772305268 1124 16459611 SGTC_1941 st076221 61.8 µM 0.726719420483793 0.27401006164933 no 914 0.23369892704586 1165 2828568 SGTC_3350 9150499 3.57 µM 0.725509324768808 0.274386212339091 no 915 0.234069813193428 1152 4910996 YPR165W RHO1 SGTC_1497 4476-2978 41.3 µM 0.724927054950931 0.274567298057024 no 916 0.234248391052884 1190 1528379 SGTC_520 3584-0023 682 µM 0.724138737239267 0.274812558507217 no 917 0.234490282410945 1091 1340790 SGTC_2894 9048625 32.47 µM 0.723900755159212 0.274886620419751 no 918 0.234563333171252 1191 4092861 SGTC_3349 9149703 23.001 µM 0.723158410386484 0.275117707185423 no 919 0.234791283492467 1164 4910494 SGTC_2093 5331342 194.4 µM 0.721201431808295 0.275727359163159 no 920 0.235392795496661 1162 33839 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.720006821346836 0.276099838873054 no 921 0.235760397824186 1215 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1777 st045864 34.765 µM 0.719485220365354 0.276262551574024 no 922 0.235921002704065 1175 4691462 SGTC_2822 7994718 71.43 µM 0.718191546617409 0.276666314251302 no 923 0.236319594744508 1102 1018011 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.718018626923947 0.276720305338718 no 924 0.236372900872456 1182 688664 SGTC_1305 1181-0477 144 µM 0.717807067475696 0.276786368020594 no 925 0.236438127519081 1145 6252086 SGTC_12 0849-0099 9.267 µM 0.717767153690936 0.276798832578174 no 926 0.236450434590947 1111 6071388 SGTC_2199 6590217 200 µM 0.716691681647509 0.277134792033669 no 927 0.236782179848861 1110 703109 SGTC_706 4262-0057 46.9 µM 0.716444277123516 0.277212105283053 no 928 0.236858531631294 1155 883298 SGTC_10 0279-0212 42.575 µM 0.715905828318524 0.277380405549792 no 929 0.237024749689547 1198 39851 YBR002C RER2 SGTC_1699 st031318 29.054 µM 0.714869348663546 0.277704513414441 no 930 0.237344889256412 1193 5340658 SGTC_1732 st034308 51.822 µM 0.714596556339264 0.277789846489128 no 931 0.237429186625648 1077 830119 SGTC_3316 9136639 10.545 µM 0.714367380849991 0.277861545531416 no 932 0.237500018369718 1152 4903665 SGTC_923 1900-2434 73.3 µM 0.712260800481748 0.278521025745733 no 933 0.238151646543209 1169 5910570 SGTC_2260 7964312 200 µM 0.704767065877042 0.280873154899894 no 934 0.240477603596482 1195 231951 SGTC_1677 st019204 53.9 µM 0.703006182171586 0.281427250186428 no 935 0.241025948392696 1129 3945625 SGTC_2782 7736369 71.43 µM 0.702547620849767 0.28157163167745 no 936 0.241168857355373 1233 2950836 YOL077C BRX1 SGTC_2127 5253358 187.912 µM 0.701856826238798 0.281789200995427 no 937 0.241384227902668 1141 20612 SGTC_2133 5320837 200 µM 0.701074866696061 0.282035580907416 no 938 0.24162814716795 1152 2841355 SGTC_365 0121-0052 13.6 µM 0.700974028254356 0.282067360646541 no 939 0.241659611779696 1194 3101739 SGTC_912 3474-0017 2.18 µM 0.700489847010427 0.282219976798753 no 940 0.241810721794314 1208 3360550 SGTC_1653 st012112 65 µM 0.699541984959194 0.282518862275597 no 941 0.242106692144932 1177 720429 SGTC_3000 9075062 71.4286 µM 0.699490663440164 0.28253504962334 no 942 0.242122722915909 1163 17057871 SGTC_762 1165-0429 115 µM 0.699425917212727 0.282555471901656 no 943 0.242142947844902 1182 5967793 SGTC_555 4296-0685 37 µM 0.699308133904201 0.282592624974813 no 944 0.242179742438311 1179 2908540 YHR072W ERG7 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.698425390499768 0.282871148580367 no 945 0.242455601099579 1195 5282362 SGTC_715 0868-0130 184 µM 0.697623072024532 0.283124410786117 no 946 0.242706474434413 1212 2876258 SGTC_2047 4141938 200 µM 0.693424468940043 0.284451525697324 no 947 0.244021605461437 1179 3807862 SGTC_2231 micatex 6.853 µM 0.693105554379532 0.284552451082101 no 948 0.244121656106451 1197 20737 An antifungal of unknown mechanism. SGTC_2321 7390090 138.78 µM 0.692230984383668 0.284829309838098 no 949 0.244396141793249 1150 649046 SGTC_255 tunicamycin 200.472 nM 0.692163508212652 0.284850675810735 no 950 0.244417326244189 1188 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2114 5491910 81.25 µM 0.691725741304016 0.284989310956523 no 951 0.244554789187478 1225 2849228 SGTC_594 1487-1584 10.8 µM 0.690998861578906 0.285219575453259 no 952 0.244783128232324 1186 5013332 SGTC_2483 5729050 27.16 µM 0.689233934114716 0.285779046430205 no 953 0.245338032689269 1238 2865180 SGTC_2437 5741531 144.16 µM 0.687548121341553 0.286313925440739 no 954 0.245868693681908 1267 2262990 SGTC_1673 st016611 27.3 µM 0.686504938857441 0.286645146935052 no 955 0.246197375484314 1218 5226799 SGTC_804 1595-0054 20.9 µM 0.686029217008054 0.286796253967615 no 956 0.2463473422255 1198 761523 Stimulates phospholipase C. SGTC_146 3448-8650 53.125 µM 0.685934940227943 0.286826204277235 no 957 0.24637706788668 1218 2891488 YIL048W NEO1 SGTC_1782 st039423 80.636 µM 0.685635198827759 0.286921437441769 no 958 0.246471589733169 1192 2068169 SGTC_1199 1638-0010 4.46 µM 0.685482085460275 0.286970090057146 no 959 0.246519880711121 1198 3111136 SGTC_1736 st036774 51 µM 0.683188112367739 0.287699480100893 no 960 0.247243991681423 1245 1272247 SGTC_1928 4'-methoxychalcone 40.3 µM 0.682862021879711 0.287803234672263 no 961 0.247347016998693 1240 641818 SGTC_990 3985-0011 41.3 µM 0.680965968467689 0.288406865602097 no 962 0.247946512153013 1192 5399565 YGL099W LSG1 SGTC_3043 9092303 49.47 µM 0.680955497665903 0.288410200761515 no 963 0.247949824968102 1177 25236084 SGTC_791 1348-1292 225 µM 0.680487353827045 0.288559332494724 no 964 0.248097963258022 1228 5437054 SGTC_2014 4013930 200 µM 0.677967326614895 0.289362734979295 no 965 0.248896204941688 1201 64556 SGTC_2189 6047310 154.431 µM 0.674490759476595 0.290472811060205 no 966 0.249999679274407 1175 711535 SGTC_2795 7780010 54.55 µM 0.674007148066439 0.290627387110242 no 967 0.250153384607547 1214 953673 SGTC_3134 9127454 49.47 µM 0.673360797488579 0.290834039319972 no 968 0.250358891270484 1316 24262820 SGTC_2841 9004761 38.96 µM 0.672587283913772 0.291081438534572 no 969 0.250604946899144 1144 2991039 SGTC_2185 6113692 200 µM 0.670384840806419 0.291786401898709 no 970 0.251306247853498 1228 874150 SGTC_2005 4024620 188 µM 0.670011532488154 0.291905970136701 no 971 0.251425219277238 1247 236743 SGTC_838 0109-0203 71.4 µM 0.668748432343621 0.29231070206912 no 972 0.251827983388969 1241 759422 SGTC_1121 fusaric acid 630.51 nM 0.667287277181479 0.292779221576853 no 973 0.252294325775416 1237 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1049 3226-0134 66 µM 0.664802420556062 0.293576790709329 no 974 0.253088437128155 1277 5702385 SGTC_2412 st077135 33.4 µM 0.664540411466014 0.293660946859511 no 975 0.25317224664922 1310 13258915 SGTC_2815 7968870 71.43 µM 0.66396367541037 0.293846231238083 no 976 0.253356780106948 1248 2977326 YHR190W ERG9 SGTC_495 decylubiquinone 155 µM 0.661001637037208 0.294798677711254 no 977 0.254305631863902 1204 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1716 st033144 30.6155 µM 0.660923057480944 0.2948239644168 no 978 0.254330829178408 1267 674617 SGTC_1624 st003710 6.25 µM 0.659386924560602 0.295318488863179 no 979 0.254823668179977 1264 24207033 SGTC_805 3852-0218 479 µM 0.658939259452126 0.295462676664589 no 980 0.254967387021031 1215 6615355 SGTC_712 r015-0009 80.6 µM 0.658005182365615 0.295763636407369 no 981 0.255267400553512 1224 6813872 YLR060W FRS1 SGTC_3332 9141069 11.198 µM 0.658004017315635 0.295764011874537 no 982 0.25526777486777 1217 17332883 SGTC_1726 st035556 14.5795 µM 0.657445546141667 0.295944018707862 no 983 0.255447236873637 1320 5919439 SGTC_2204 7233102 200 µM 0.656461363884938 0.296261363417701 no 984 0.255763659461318 1200 2172480 SGTC_1646 st011709 75.6 µM 0.654219328823085 0.296984878648123 no 985 0.256485255229818 1222 5757843 SGTC_961 1252-1571 372 µM 0.653371767987962 0.297258600879534 no 986 0.256758317470934 1277 6813498 SGTC_2317 5986382 200 µM 0.652835940902652 0.297431707252692 no 987 0.25693102518379 1319 877883 SGTC_1188 1403-0014 4.57 µM 0.652109234146117 0.297666553484451 no 988 0.257165353747883 1291 9614867 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.651699679230853 0.297798944593212 no 989 0.257297464783771 1291 66535 A nucleotide analog. SGTC_3125 9127534 49.47 µM 0.651645345865355 0.297816510200544 no 990 0.257314993867679 1159 1639235 SGTC_3116 9124943 49.47 µM 0.650799149836737 0.298090140584095 no 991 0.257588074548767 1182 41905195 YPL160W CDC60 SGTC_2174 5790901 200 µM 0.650226217624102 0.298275471956498 no 992 0.257773054137944 1266 786020 SGTC_711 k292-0785 179 µM 0.649916673219138 0.298375624806066 no 993 0.257873023781701 1267 4146315 SGTC_2713 st079149 53.4 µM 0.647932714511759 0.299017896198105 no 994 0.258514235193098 1290 3103253 SGTC_771 0250-0039 27.3 µM 0.645620273958898 0.299767299029251 no 995 0.25926265209832 1269 3005115 SGTC_641 4092-0595 30 µM 0.644114106627364 0.30025586626875 no 996 0.259750721726868 1286 786260 SGTC_1452 4194-0072 190 µM 0.643816314834592 0.300352505917929 no 997 0.259847276498466 1340 1343545 SGTC_1225 1216-0074 20.6 µM 0.6436953575126 0.300391763105886 no 998 0.259886500484595 1270 4241466 SGTC_3163 9099914 49.47 µM 0.643055843499705 0.300599358484419 no 999 0.260093932553685 1310 16268368 SGTC_3310 9130229 44.1445 µM 0.642906743876386 0.300647767660118 no 1000 0.260142306612234 1305 7761258 SGTC_3259 9138485 49.47 µM 0.639734422037316 0.301678579478848 no 1001 0.261172636402801 1395 17646153 SGTC_490 phenamil 164 µM 0.638916714591118 0.301944542117992 no 1002 0.261438556927967 1233 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2235 salicylic acid 500 µM 0.638812676175505 0.301978388583878 no 1003 0.261472400450696 1279 338 A COX inhibitor and kinase inhibitor. SGTC_231 b-estradiol 524 µM 0.638595975047981 0.302048892699875 no 1004 0.261542900187007 1218 450 A steroid. SGTC_758 0868-0029 16 µM 0.638473055315914 0.302088888149373 no 1005 0.261582894203706 1289 762687 SGTC_1679 SEC14.276 6.7 µM 0.637855275324655 0.302289936531019 no 1006 0.261783946911054 1308 1005053 YMR079W SEC14 SGTC_3045 9092950 49.47 µM 0.637424228346296 0.302430250653494 no 1007 0.261924275441323 1341 44120432 SGTC_2596 sinensetin 100 µM 0.636697389884155 0.302666916740882 no 1008 0.262160987029233 1280 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2039 Aminomethylbenzodioxan 200 µM 0.636690776947914 0.302669070361881 no 1009 0.262163141186432 1263 15053 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.636148594329795 0.30284566518335 no 1010 0.262339787469058 1247 6708514 SGTC_2484 5809818 12.04 µM 0.635861450556547 0.302939209739783 no 1011 0.262433365281879 1299 2870548 SGTC_60 0986-0278 202 µM 0.635013810379245 0.303215425991398 no 1012 0.262709703953442 1116 3110598 SGTC_2857 9024691 58.44 µM 0.634836087710928 0.303273353862987 no 1013 0.262767662086883 1311 16478292 SGTC_2451 5856223 45.7 µM 0.633663645180943 0.303655629919237 no 1014 0.263150177699678 1265 2179896 SGTC_532 1548-0774 215 µM 0.632997080309856 0.303873059921032 no 1015 0.263367774812664 1398 5932993 SGTC_2249 haloperidol 116.36 µM 0.631734660140874 0.304285045001142 no 1016 0.263780137823919 1292 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_647 0140-0236 81 µM 0.630323061312657 0.304746008192804 no 1017 0.264241618862678 1298 990837 SGTC_837 0091-0265 12.5 µM 0.629316295557519 0.305074961078906 no 1018 0.264571002544281 1270 759367 SGTC_1682 st012968 530 nM 0.626509555214106 0.305992872959875 no 1019 0.265490385749306 1256 24207270 SGTC_2884 9058502 51.95 µM 0.625300989171318 0.306388496500845 no 1020 0.265886765442118 1303 6471554 SGTC_3304 9125678 46.087 µM 0.623832950296409 0.306869362073629 no 1021 0.266368648830785 1297 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_180 1486-1293 102.781 µM 0.623457218332891 0.306992488966415 no 1022 0.266492053740023 1369 4140536 SGTC_3172 9105863 49.47 µM 0.622854850188325 0.307189929676835 no 1023 0.266689955061532 1284 2348785 SGTC_374 0880-0231 82.3 µM 0.622497404526665 0.30730711756242 no 1024 0.266807424950774 1279 6833587 SGTC_1343 1487-0095 224 µM 0.622188264624372 0.307408484364817 no 1025 0.266909040858515 1303 4560101 YGL055W OLE1 SGTC_2800 7887935 81.82 µM 0.621006287916195 0.307796189479251 no 1026 0.267297742995836 1317 2961002 SGTC_2877 9040724 71.43 µM 0.620612404009675 0.307925436700605 no 1027 0.267427338170822 1347 6463895 SGTC_2984 9022109 38.96 µM 0.620058249589561 0.30810731468531 no 1028 0.267609718984632 1342 6459207 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.619336531474939 0.308344259099982 no 1029 0.267847341576172 1284 77254 SGTC_2889 9059656 51.95 µM 0.617685292611269 0.308886671070308 no 1030 0.268391404350466 1372 3949838 SGTC_1389 3405-0187 19 µM 0.617185539892467 0.309050916056228 no 1031 0.268556176173715 1273 799890 SGTC_1273 0849-0096 14.1 µM 0.616590873430981 0.30924640442655 no 1032 0.268752307919804 1312 5286025 SGTC_426 0988-0037 14.6 µM 0.614190430934689 0.31003606530986 no 1033 0.269544747975214 1329 5383008 SGTC_2104 5389443 200 µM 0.613123204807824 0.310387426911857 no 1034 0.269897438950253 1383 2244536 SGTC_3219 9131112 49.47 µM 0.612429224641003 0.310615998091903 no 1035 0.270126905551741 1268 17612988 YMR079W SEC14 SGTC_2497 7-hydroxyflavone 100 µM 0.611847872428879 0.310807530119597 no 1036 0.270319206473697 1346 5281894 SGTC_2619 obliquin 87.91 µM 0.611053297568853 0.311069393310123 no 1037 0.2705821482818 1324 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2080 5212524 12.4 µM 0.610786455886267 0.311157356163205 no 1038 0.270670480547468 1308 260183 SGTC_1171 0368-0077 21.4 µM 0.610450460233112 0.311268130573911 no 1039 0.270781725242636 1286 3239779 SGTC_342 k048-0088 23.3 µM 0.610186804888906 0.311355067077534 no 1040 0.270869034786912 1302 6820570 SGTC_464 bw-b 70c 158 µM 0.609792825699571 0.311484995575243 no 1041 0.270999527288277 1353 5353454 SGTC_1741 st038134 10.228 µM 0.609751831497498 0.311498516204496 no 1042 0.271013107055275 1406 1272587 SGTC_224 benfluorex 43.875 µM 0.609209885816756 0.311677283580044 no 1043 0.271192664247524 1340 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3336 9143619 71.43 µM 0.608804458799316 0.311811047643149 no 1044 0.271327028910634 1347 45595730 SGTC_2735 sertaconazole 140 nM 0.605952790983916 0.312752609859235 no 1045 0.272273051224585 1401 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1801 st050089 28.441 µM 0.60544457940321 0.312920539482473 no 1046 0.272441819035388 1344 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_544 k015-0020 52.4 µM 0.603849482988037 0.313447863216376 no 1047 0.272971858701331 1337 3008304 SGTC_840 0245-0196 390 µM 0.601778633650999 0.314133035498438 no 1048 0.273660749708382 1403 3827528 SGTC_3288 9119690 36.221 µM 0.601704186693714 0.314157679368403 no 1049 0.273685531322037 1300 17595618 YKL019W RAM2 SGTC_1100 amiodarone 5.07 µM 0.600542881089953 0.314542208802317 no 1050 0.274072245882516 1368 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_69 0096-0274 206.684 µM 0.600456666264371 0.314570764131507 no 1051 0.274100966166464 1441 6741392 SGTC_3344 9148862 3.898 µM 0.598752986552585 0.315135269544026 no 1052 0.27466880869544 1395 4905352 SGTC_1496 4469-0713 57.4 µM 0.5987249132616 0.315144575104278 no 1053 0.274678170479971 1351 746691 SGTC_987 1497-1013 404 µM 0.598598760922578 0.315186392746514 no 1054 0.274720241270376 1326 1676435 SGTC_1881 5652484 16 µM 0.598383129214547 0.315257876965217 no 1055 0.27479216006693 1329 2255129 SGTC_1375 2910-0797 186 µM 0.59825011039856 0.31530197757604 no 1056 0.274836529938433 1363 742508 SGTC_3253 9135987 49.47 µM 0.597593634864907 0.315519661800933 no 1057 0.275055556191043 1344 4182430 SGTC_3121 9125696 49.47 µM 0.596377227141683 0.315923186143407 no 1058 0.275461625123566 1399 1235365 SGTC_3141 9094609 49.47 µM 0.596357508798089 0.315929729205926 no 1059 0.275468210054175 1304 25236309 YDL196W YDL196W SGTC_549 1661-1316 519 µM 0.595334648701716 0.316269220003528 no 1060 0.275809899804418 1396 2857282 SGTC_2281 7943571 200 µM 0.594988530338697 0.316384132980107 no 1061 0.275925568913954 1401 1244024 SGTC_796 1234-0020 70.7 µM 0.593458091030364 0.316892458677902 no 1062 0.276437311038409 1304 46495034 SGTC_2010 4012422 159 µM 0.593421227778442 0.316904706842107 no 1063 0.276449642962123 1372 952393 SGTC_2192 5915882 198.485 µM 0.592480848497428 0.317217224574085 no 1064 0.276764320762818 1314 2876149 SGTC_3147 9097027 49.47 µM 0.592110887390434 0.317340210084473 no 1065 0.276888168408878 1425 25236841 SGTC_954 1189-0853 2.85 µM 0.590448376163259 0.317893124544642 no 1066 0.277445043029026 1335 2828194 SGTC_1262 0737-0114 49.6 µM 0.589939524987678 0.318062438446844 no 1067 0.277615597137482 1371 765919 SGTC_230 MPP+ 141.667 µM 0.588592141330834 0.318510947210679 no 1068 0.278067453463 1307 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2833 9001315 45.46 µM 0.588158328863065 0.318655408688319 no 1069 0.278213012403194 1397 2989378 SGTC_188 3229-0966 278.469 µM 0.588079072129141 0.318681804511411 no 1070 0.278239609765342 1459 5722370 SGTC_1393 3470-5649 58.2 µM 0.587829987214475 0.318764766244359 no 1071 0.278323206968268 1313 4108395 SGTC_1600 coumarin 106 71.1 µM 0.58635319029578 0.319256823650057 no 1072 0.278819096864026 1399 100336 A hepatotoxic, DNA x-linker. SGTC_172 1112-0046 2.638 µM 0.586079728149137 0.319347974119398 no 1073 0.278910969185676 1354 2802135 YIL048W NEO1 SGTC_1297 1068-0111 14.1 µM 0.584901044569962 0.319740978118444 no 1074 0.27930712809476 1310 767057 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.582401027577789 0.320575219052354 no 1075 0.280148294778016 1413 5377381 SGTC_296 1222-0039 74.9 µM 0.581113125423785 0.321005338758997 no 1076 0.280582106538945 1321 5984176 SGTC_2145 5634607 200 µM 0.579598059934082 0.321511631637622 no 1077 0.281092850822269 1343 308662 SGTC_1425 4048-4433 7.33 µM 0.579393229137407 0.321580105887954 no 1078 0.281161935856145 1404 23734946 SGTC_815 1582-0027 36.9 µM 0.578596894633326 0.321846375431106 no 1079 0.281430600288422 1407 3128206 SGTC_1384 3089-0840 101 µM 0.578369720306422 0.321922352257738 no 1080 0.28150726623897 1401 1069836 SGTC_1904 st060225 78 µM 0.577849652162696 0.322096313350165 no 1081 0.281682814834687 1334 66595 SGTC_2792 7535235 81.82 µM 0.577136059680802 0.322335071139474 no 1082 0.281923773281577 1329 1281891 SGTC_613 3914-0030 117 µM 0.576096503775909 0.322683022781231 no 1083 0.282274977247776 1245 1145395 SGTC_675 1309-0189 238 µM 0.574065967741347 0.323363114968546 no 1084 0.28296158092147 1339 4246530 SGTC_820 1582-0060 59.9 µM 0.572575224850276 0.323862789120733 no 1085 0.283466169303017 1354 3848840 SGTC_3227 9130768 49.47 µM 0.572323730454727 0.323947117518273 no 1086 0.283551337915509 1404 17720899 SGTC_1788 fluconazole 20 µM 0.571958368191994 0.324069642963775 no 1087 0.283675089738789 1365 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1379 2144-0755 36.5 µM 0.570888067604301 0.324428681471482 no 1088 0.284037759981369 1404 5392327 SGTC_35 0133-0054 64.071 µM 0.570761184496342 0.324471255973537 no 1089 0.284080768893038 1305 99677 SGTC_2756 carbadox 75.1 µM 0.570086413042503 0.324697708085162 no 1090 0.284309545004367 1376 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_58 0957-0393 9 µM 0.566228246866333 0.325993744484814 no 1091 0.285619315146352 1344 6997992 SGTC_757 1066-0008 322 µM 0.565888180208914 0.326108080954436 no 1092 0.285734898525002 1440 6842497 SGTC_901 1112-0062 60.1 µM 0.564856113138217 0.326455180358339 no 1093 0.286085818266071 1393 1908457 SGTC_2472 5377652 49.4 µM 0.563596749350206 0.326878926619841 no 1094 0.286514299795176 1365 1610903 SGTC_71 0417-1750 47.813 µM 0.563466824909967 0.326922655853697 no 1095 0.286558522152424 1512 6811472 SGTC_1766 st045414 44.774 µM 0.56204440151905 0.327401562429298 no 1096 0.287042883773342 1397 253960 SGTC_2254 7938975 95.19 µM 0.561387977337269 0.327622665550047 no 1097 0.287266539092796 1470 2969277 SGTC_774 k060-0086 136 µM 0.561361453923642 0.32763160069326 no 1098 0.287275577821705 1427 5911235 SGTC_1956 st077085 54 µM 0.560685492537856 0.327859350227084 no 1099 0.287505979390495 1369 24208685 SGTC_1034 k072-0165 12.7 µM 0.55977495574155 0.328166235732692 no 1100 0.287816474081408 1463 5835461 SGTC_2362 9071156 126 µM 0.559292581283498 0.328328861283404 no 1101 0.287981028797816 1457 653133 SGTC_2851 9015922 71.43 µM 0.559041452906741 0.328413538452726 no 1102 0.288066715004007 1453 2996893 SGTC_827 3253-0474 693 µM 0.558600276013312 0.328562318812597 no 1103 0.28821727580499 1433 5402065 SGTC_1912 st060209 90.8 µM 0.558172608672675 0.32870656922488 no 1104 0.288363261611884 1351 688787 SGTC_205 1486-1330 71.903 µM 0.556885479203255 0.329140866580359 no 1105 0.288802838172884 1432 4118834 SGTC_2653 dihydrofissinolide 100 µM 0.556586096493649 0.329241916020254 no 1106 0.288905127651123 1416 6857746 SGTC_1882 5615643 20 µM 0.553229819880011 0.330375598961615 no 1107 0.290053025061077 1345 2253075 SGTC_2110 5483698 200 µM 0.553036599273762 0.330440912552237 no 1108 0.290119174464081 1414 2848765 YHR062C RPP1 SGTC_2286 7945697 125 µM 0.54993569067381 0.331489805745121 no 1109 0.291181741666608 1351 1245733 SGTC_233 rapamycin 362 pM 0.549511567163715 0.331633370034668 no 1110 0.291327214322608 1438 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3171 9103192 49.47 µM 0.549270588861249 0.331714951348116 no 1111 0.291409884017202 1444 13018434 SGTC_1439 4092-1168 46 µM 0.548599747120293 0.331942101584287 no 1112 0.2916400797129 1419 2886240 SGTC_2537 larixol 68.93 µM 0.548226620273728 0.332068470871591 no 1113 0.291768152837375 1406 6708759 SGTC_1165 k072-0275 30.3 µM 0.547895297193917 0.33218069821833 no 1114 0.291881899080251 1410 6153523 YGL055W OLE1 SGTC_2950 9072895 21.46 µM 0.547292343933786 0.332384972062442 no 1115 0.292088951426459 1359 17332245 SGTC_260 nsc-65238 3.989 µM 0.54727977863553 0.332389229575335 no 1116 0.292093267039378 1439 3246252 SGTC_1893 st059353 36.1 µM 0.546656570577921 0.332600418927256 no 1117 0.292307348112003 1373 3112488 SGTC_1488 4013-0813 75.9 µM 0.546021105140881 0.33281581671296 no 1118 0.29252571488505 1391 2910057 SGTC_1182 1222-0449 220 µM 0.54594453901089 0.332841773345932 no 1119 0.292552030636053 1443 658318 SGTC_1088 bifonazole 369 nM 0.545152223911704 0.333110422581815 no 1120 0.292824413617329 1355 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1090 efavirenz 20.7 µM 0.544794975542956 0.333231582344225 no 1121 0.292947267364625 1434 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1953 st076800 12.1 µM 0.54405046579216 0.333484136618281 no 1122 0.293203372834235 1367 297591 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.541273456980907 0.334426824978384 no 1123 0.294159556389627 1469 688801 SGTC_125 0133-0007 11.75 µM 0.541228918112397 0.334441952751921 no 1124 0.294174903808378 1499 26541 SGTC_1298 1079-1278 263 µM 0.54021897811363 0.334785054323262 no 1125 0.294523013084943 1436 2840950 SGTC_1281 0884-0031 11.8 µM 0.539745977527423 0.334945791768347 no 1126 0.294686113743903 1406 1548255 SGTC_1159 4092-0538 61.2 µM 0.53937754968663 0.335071013727494 no 1127 0.294813184350335 1476 717301 SGTC_2482 5981709 142.65 µM 0.53925814138545 0.335111602383979 no 1128 0.294854373642339 1455 877755 SGTC_2961 9083290 32.55 µM 0.539178031827577 0.33513883389272 no 1129 0.294882008517431 1461 17741490 SGTC_1467 k284-1082 293 µM 0.539011248656447 0.335195530998486 no 1130 0.294939546456651 1492 3334705 SGTC_2295 7971645 200 µM 0.538002173684613 0.335538641034986 no 1131 0.295287773962421 1490 2978226 YKL099C UTP11 SGTC_1780 st038448 24.544 µM 0.536804821936749 0.335945947717772 no 1132 0.295701220281355 1519 728868 YDL195W SEC31 SGTC_2195 6536160 144.242 µM 0.536633204872094 0.336004343005265 no 1133 0.29576050155362 1333 3834386 SGTC_206 4546-0025 72.014 µM 0.535950683654719 0.336236620280637 no 1134 0.295996317247677 1425 6620745 YIL048W NEO1 SGTC_656 4090-1979 187 µM 0.535621532842833 0.336348660038415 no 1135 0.296110071919415 1496 22330961 SGTC_371 0195-0006 7.36 µM 0.534689865929971 0.336665869226989 no 1136 0.296432165134298 1349 3928593 SGTC_1258 0671-0043 57.1 µM 0.534218709972863 0.336826330273371 no 1137 0.296595112937793 1404 4298767 SGTC_3182 9108849 49.47 µM 0.53224867241948 0.337497585206201 no 1138 0.297276888250827 1433 17133045 SGTC_1768 st044301 37.178 µM 0.528615567673094 0.338736856223589 no 1139 0.298536079361711 1411 3931349 SGTC_1931 st074438 57.1 µM 0.527877052995191 0.338988981626998 no 1140 0.298792336233104 1409 2787313 SGTC_559 1550-0661 158 µM 0.524152646434226 0.34026157355056 no 1141 0.300086186873048 1519 5830875 SGTC_2417 cerulenin 830 nM 0.520888749010585 0.34137831257372 no 1142 0.301222136769809 1493 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_993 3909-8757 62.7 µM 0.518203345558829 0.34229816365266 no 1143 0.302158200401572 1455 4288324 YLR208W SEC13 SGTC_726 3448-4391 34.2 µM 0.516713695485254 0.342808828665092 no 1144 0.302678017107205 1562 1356692 SGTC_2514 salinomycin 42.74 µM 0.516218402514013 0.342978683105732 no 1145 0.302850939399828 1570 23682228 A polyether potassium ionophore. SGTC_226 1,3-diallylurea 8.28947 mM 0.514065039303611 0.343717520257721 no 1146 0.303603259584906 1446 74537 YKL182W FAS1 SGTC_3224 9130643 49.47 µM 0.513836619249193 0.343795928203501 no 1147 0.303683111592435 1506 17644395 SGTC_2477 5967686 25.23 µM 0.509878401992607 0.345155698617133 no 1148 0.305068327012642 1408 776118 SGTC_1707 st032323 6.317 µM 0.509804518169135 0.345181099085335 no 1149 0.305094210008328 1453 3132057 YMR211W DML1 SGTC_630 4356-0227 183 µM 0.509356951217497 0.34533498272184 no 1150 0.305251022588777 1482 779312 SGTC_1249 0481-0015 10.2 µM 0.509113508652649 0.34541869451805 no 1151 0.305336331783943 1417 4227577 SGTC_3169 9102970 49.47 µM 0.508098223966334 0.345767898622417 no 1152 0.305692230363939 1509 17027839 SGTC_266 formosanin C 406 nM 0.507930203524262 0.34582570141232 no 1153 0.305751146080884 1468 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3192 9110362 49.47 µM 0.506988919935208 0.346149590444813 no 1154 0.306081296478189 1531 16649480 SGTC_2149 5554786 194.827 µM 0.506432013247978 0.346341271120672 no 1155 0.306276702861539 1470 745063 YPR165W RHO1 SGTC_1813 st051246 8.6015 µM 0.504622039437764 0.34696451426904 no 1156 0.306912163552014 1506 5291959 SGTC_1348 1493-0373 93.8 µM 0.502952692990957 0.347539701329398 no 1157 0.307498766395873 1502 3010129 SGTC_1309 pyrazolanthrone 13.4 µM 0.502657914551493 0.347641306187532 no 1158 0.307602401788467 1569 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2072 5231554 129 µM 0.501266056805976 0.348121202411778 no 1159 0.308091945193509 1551 789545 SGTC_886 0866-0150 153 µM 0.500007739605121 0.34855526487819 no 1160 0.308534813884653 1587 271463 SGTC_1196 1588-0294 184 µM 0.496667377053214 0.349708499659821 no 1161 0.309711815623801 1455 6144269 SGTC_1428 4049-0204 61.7 µM 0.495401666174648 0.350145839960679 no 1162 0.310158309415484 1562 X1428 SGTC_1735 st034310 56.75 µM 0.494879060624079 0.350326473560608 no 1163 0.310342746138979 1597 871153 SGTC_542 3381-0244 89.3 µM 0.492740942647696 0.351065845803358 no 1164 0.311097822160313 1584 1112843 SGTC_629 3448-6466 76.7 µM 0.492140431961884 0.351273607102697 no 1165 0.311310035688536 1490 573744 SGTC_148 3253-0744 288.01 µM 0.491848562153822 0.351374602629635 no 1166 0.311413201757675 1454 6893655 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.491800582512503 0.351391205999479 no 1167 0.311430162349812 1461 688803 SGTC_2788 5282734 71.43 µM 0.491549020469192 0.35147826376362 no 1168 0.31151909497492 1632 743706 SGTC_940 3232-1287 54.8 µM 0.491284160054264 0.351569932098915 no 1169 0.31161274074711 1478 1585493 YIL048W NEO1 SGTC_899 1083-0020 478 µM 0.490775447110158 0.351746022136951 no 1170 0.311792638782724 1558 767123 SGTC_1219 1469-0211 33.1 µM 0.485764170579699 0.353482360966687 no 1171 0.313567190160228 1519 6822282 SGTC_1519 esterone 74 µM 0.484198398514792 0.354025507386676 no 1172 0.314122536680089 1427 698 A steroid. SGTC_1329 1447-1697 50.6 µM 0.483856892364361 0.354144011040894 no 1173 0.314243717737713 1483 2840515 SGTC_268 camptothecin 39.6153 µM 0.483427662219062 0.354292975218797 no 1174 0.314396055439542 1516 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_847 0342-0274 5.54 µM 0.481136263506123 0.355088581094926 no 1175 0.315209828111993 1595 18097 SGTC_2438 5259590 200 µM 0.480955229661111 0.355151465584955 no 1176 0.315274159197762 1602 1201127 SGTC_541 4513-1321 94 µM 0.478995647384078 0.355832404443994 no 1177 0.315970862567274 1464 747515 SGTC_473 2-arachidonoylglycerol 10 µM 0.478877894355055 0.355873337341174 no 1178 0.316012748946999 1488 5282280 An endocannabinoid. SGTC_2909 7941780 10.49 µM 0.476453095081947 0.356716606389375 no 1179 0.316875808021518 1573 1243215 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.475962809675016 0.356887197561969 no 1180 0.31705043674442 1601 16725076 SGTC_2864 9034755 47.6 µM 0.474708367289882 0.357323801721622 no 1181 0.317497426597092 1495 4930451 SGTC_964 1287-0107 19.4 µM 0.473342613952931 0.35779935970441 no 1182 0.317984382112238 1623 51516812 YPR165W RHO1 SGTC_1032 k061-1018 98.7 µM 0.473285286180229 0.357819326180686 no 1183 0.31800482905994 1670 4005393 SGTC_578 3460-0051 92 µM 0.472407521337975 0.358125088174791 no 1184 0.318317968411913 1558 2876744 SGTC_2309 7664088 163.95 µM 0.471665244351259 0.358383725154156 no 1185 0.318582874332569 1596 704922 SGTC_131 0141-0277 33.849 µM 0.471065341435332 0.358592801186283 no 1186 0.31879703717483 1602 1547771 SGTC_3153 9100258 49.47 µM 0.47081698846963 0.358679368689194 no 1187 0.318885715868825 1475 25236848 SGTC_2854 9024559 71.43 µM 0.469242706576974 0.359228279206678 no 1188 0.319448081295326 1481 3163529 SGTC_2916 7875993 68.79 µM 0.468521112691079 0.359479977167304 no 1189 0.319705988235539 1652 1299250 SGTC_622 1348-1566 26.3 µM 0.465424444071121 0.360560812119636 no 1190 0.320813766295562 1611 7340407 SGTC_2691 st077356 60.2 µM 0.464467826692934 0.360894927564285 no 1191 0.321156302541687 1637 2839272 SGTC_2627 acetyl isogambogic acid 100 µM 0.464223448936774 0.360980297831751 no 1192 0.321243831372863 1466 6857789 A caspase activator and apoptosis inducer. SGTC_1328 1441-0025 69.2 µM 0.46416199189855 0.36100176815811 no 1193 0.321265845015721 1440 4562601 SGTC_1473 k844-0725 134 µM 0.463231483741296 0.361326899358683 no 1194 0.32159922567188 1572 54682906 SGTC_584 0986-0246 15.4 µM 0.463032584541201 0.361396410233421 no 1195 0.321670505544006 1598 53315 YDR232W HEM1 SGTC_3356 9151811 4.48 µM 0.461885185386887 0.361797490146693 no 1196 0.322081829191728 1508 1859254 YPR165W RHO1 SGTC_1792 st045773 43.6 µM 0.461612409959981 0.361892862710025 no 1197 0.322179646773428 1525 2919270 SGTC_606 k015-0008 38.6 µM 0.461438240382293 0.361953763441796 no 1198 0.322242110627959 1641 1970475 SGTC_577 r071-0003 38.6 µM 0.459047850885353 0.362789947837101 no 1199 0.323099902116578 1522 4568517 YMR134W ERG29 SGTC_1153 4055-0057 267 µM 0.457013212983007 0.363502202451746 no 1200 0.323830774227423 1515 882706 SGTC_1776 st049249 45.9 µM 0.456842655975944 0.363561929894326 no 1201 0.323892071753856 1495 1822314 SGTC_3223 9129970 49.47 µM 0.453430956235482 0.364757369618355 no 1202 0.325119224874761 1592 17248386 SGTC_802 4112-3352 742 µM 0.452394827744294 0.365120684092752 no 1203 0.325492286204398 1646 704594 SGTC_3180 9109287 49.47 µM 0.452152777357462 0.365205575593279 no 1204 0.325579462424036 1541 18891271 SGTC_1811 st050069 61.5 µM 0.451990100092117 0.365262633199383 no 1205 0.325638057194064 1566 3877702 SGTC_1059 3448-6867 171 µM 0.45173143190556 0.365353364909935 no 1206 0.32573123583268 1588 3934407 SGTC_2435 5706476 10.6 µM 0.450551697239835 0.365767269873469 no 1207 0.326156343255934 1644 5725375 SGTC_2390 9097792 176.6 µM 0.450476442491656 0.365793677995041 no 1208 0.326183468342505 1494 4497149 SGTC_2092 5303694 80.6725 µM 0.44763352071163 0.366791770516118 no 1209 0.327208853523978 1534 1963699 SGTC_1151 3909-8316 15.3 µM 0.447125757422765 0.36697013102488 no 1210 0.327392131236935 1543 800431 SGTC_2917 7979103 53.79 µM 0.446498089518405 0.367190649762837 no 1211 0.327618746163448 1658 2980565 SGTC_634 1611-4317 11.2 µM 0.446458926962245 0.367204410207471 no 1212 0.327632887625139 1603 2843522 SGTC_871 0574-0004 149 µM 0.446430634456963 0.367214351376964 no 1213 0.327643104103417 1563 9551173 SGTC_484 loperamide 105 µM 0.446368626703718 0.367236139422488 no 1214 0.327665495674142 1554 3955 An opioid-receptor agonist. SGTC_2818 7996756 12.99 µM 0.444690324905255 0.3678260168088 no 1215 0.32827178108047 1528 2241621 SGTC_2743 auranofin 4.32 µM 0.443371517411416 0.368289760642271 no 1216 0.32874851707765 1592 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_338 4055-0136 114 µM 0.442875670194432 0.368464169434446 no 1217 0.328927833155711 1519 2900563 SGTC_1854 st056233 32.9 µM 0.44270382006895 0.368524622147968 no 1218 0.328989989495466 1675 5393174 SGTC_2264 7948757 110.76 µM 0.441471844175364 0.368958096646642 no 1219 0.329435720288746 1521 2971411 SGTC_2299 7976368 114.88 µM 0.438929119764427 0.369853288679166 no 1220 0.330356448052931 1678 2979718 SGTC_2956 9076196 2.52 µM 0.438846688531399 0.369882321270269 no 1221 0.330386313869777 1580 16423868 SGTC_2272 7805186 180 µM 0.437940594074356 0.370201500001395 no 1222 0.330714673849137 1591 2956062 YPR165W RHO1 SGTC_1247 0448-0043 5.84 µM 0.435090605629842 0.371206012231876 no 1223 0.331748331054341 1582 3089013 YGL099W LSG1 SGTC_624 k048-0052 28 µM 0.434787495433411 0.371312898792936 no 1224 0.331858341123437 1572 6835531 SGTC_1974 st069448 26.9 µM 0.433503033055813 0.371765952264212 no 1225 0.332324681543397 1671 6323587 YNR016C ACC1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.433166890268846 0.371884545352904 no 1226 0.332446765368448 1646 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1098 clofazimine 15.1 µM 0.429204003458143 0.373283588041494 no 1227 0.333887384885996 1632 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2906 7926292 26.41 µM 0.427343047933204 0.3739411509701 no 1228 0.334564741303521 1556 2966319 SGTC_2892 9047358 58.44 µM 0.424076199293507 0.37509636858788 no 1229 0.335755121277919 1559 6466771 SGTC_689 0833-0039 98 µM 0.424061707697779 0.375101495587673 no 1230 0.33576040543495 1692 5374726 SGTC_2377 9073351 62.6 µM 0.423321461114514 0.375363417688687 no 1231 0.33603036913887 1557 7337946 YHR072W ERG7 SGTC_1709 st033179 39.1045 µM 0.422082609511995 0.375801890156662 no 1232 0.336482360474831 1575 573381 SGTC_684 1140-0066 328 µM 0.421452745980287 0.376024882218236 no 1233 0.336712255006501 1583 6813534 SGTC_811 0416-0114 265 µM 0.421008040233921 0.376182347374466 no 1234 0.336874605373211 1594 6612453 SGTC_1880 MG-132 525 µM 0.421002438615075 0.376184330974363 no 1235 0.336876650570782 1673 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3032 9089427 49.47 µM 0.420851944623807 0.376237623911839 no 1236 0.336931598982371 1567 17173707 SGTC_1194 1488-0194 225 µM 0.41953894050153 0.376702684981938 no 1237 0.337411150973649 1595 1391452 SGTC_3257 9139206 32.98 µM 0.41953791624426 0.376703047839924 no 1238 0.337411525169092 1665 4910041 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.418771742439185 0.376974506511477 no 1239 0.337691479113317 1589 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_969 1313-0238 134 µM 0.418433227352358 0.377094463242448 no 1240 0.337815198514003 1601 5212874 SGTC_301 4119-0100 24.5 µM 0.418094786764042 0.377214405432812 no 1241 0.337938908207024 1619 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2973 9094665 17.96 µM 0.417752465877805 0.377335734838709 no 1242 0.33806405406803 1711 25237061 YIL048W NEO1 SGTC_504 lovastatin 124 µM 0.417249481837552 0.377514030338343 no 1243 0.338247967720422 1554 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1838 st055369 84.5 µM 0.416193667014397 0.377888375658812 no 1244 0.338634146756182 1573 676036 SGTC_2038 4100038 30.985 µM 0.412304196722074 0.379268397153757 no 1245 0.340058236498894 1634 3596803 SGTC_1899 st063254 59.6 µM 0.412243315856802 0.379290010556425 no 1246 0.340080545618991 1536 3093813 SGTC_1511 0906-3109 28.5 µM 0.408731031163158 0.380537548480581 no 1247 0.341368529245404 1603 2882180 SGTC_896 0964-0007 44.5 µM 0.408484185316025 0.380625273239917 no 1248 0.341459119389022 1675 6756758 SGTC_1245 0418-0076 17.2 µM 0.407415245000411 0.381005226994732 no 1249 0.341851515971961 1642 6790114 SGTC_636 0kpi-0074 126 µM 0.406431985218175 0.381354827034875 no 1250 0.342212611079369 1613 616434 SGTC_766 1391-0721 126 µM 0.404953229307574 0.381880783992842 no 1251 0.342755945255989 1712 1020919 YIL115C NUP159 SGTC_195 4234-0266 16.654 µM 0.404006079355837 0.382217776491675 no 1252 0.343104124342831 1609 2303354 SGTC_336 4111-0029 111 µM 0.402391868218667 0.382792312452863 no 1253 0.343697826827312 1597 3131175 SGTC_2998 9066762 71.4286 µM 0.401687406564547 0.383043127978605 no 1254 0.343957046903103 1710 4945196 SGTC_1087 pterostilbene 9.05 µM 0.400577010391944 0.383438571392402 no 1255 0.344365787224026 1728 5281727 Similar to reservatol, lowers cholesterol. SGTC_2401 5128683 200 µM 0.400548858720538 0.383448598577458 no 1256 0.344376152308153 1540 708373 SGTC_405 ebelactone b 50 µM 0.400056685973851 0.3836239154195 no 1257 0.344557382874814 1599 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1331 1472-0049 76.2 µM 0.397942645961831 0.384377228117114 no 1258 0.345336231756499 1592 24051409 SGTC_62 0180-0423 3.232 µM 0.396798331361874 0.384785173279171 no 1259 0.345758090658348 1678 30102 YGL099W LSG1 SGTC_1315 1237-0019 3.69 µM 0.395845217393476 0.385125053331874 no 1260 0.346109608492084 1704 825140 SGTC_166 k072-0058 166.424 µM 0.394484681627544 0.385610372709318 no 1261 0.346611617257106 1689 5846229 SGTC_1518 st038567 90.8 µM 0.393454524513972 0.3859779612898 no 1262 0.346991902652906 1621 77966 SGTC_1763 st044482 94.5 µM 0.393380536544346 0.386004366190985 no 1263 0.347019221458027 1688 88505 SGTC_1683 st010134 710 nM 0.39056118874451 0.387010930285764 no 1264 0.348060809164072 1591 3818134 SGTC_731 3966-0296 387 µM 0.390296340860305 0.387105525500344 no 1265 0.348158714376787 1650 660956 SGTC_175 3793-3120 23.7 µM 0.389619355255607 0.387347353622616 no 1266 0.348409018807099 1626 5322297 SGTC_2592 piperlongumine 83.33 µM 0.388580368454267 0.38771857832379 no 1267 0.34879329569891 1576 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1018 4259-0013 28.1 µM 0.388426523441851 0.38777355509838 no 1268 0.348850209603772 1671 6801262 SGTC_1177 0983-0204 23.6 µM 0.386186329477355 0.388574346560234 no 1269 0.349679338715926 1792 766818 SGTC_654 1124-0271 80.9 µM 0.385992542260997 0.388643641066304 no 1270 0.349751096021796 1596 5403748 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.384591674284612 0.389144669236012 no 1271 0.350269981759024 1598 2333 A French combination drug. SGTC_635 k038-0028 24.7 µM 0.382829704161277 0.389775109300742 no 1272 0.35092301776052 1699 4035102 SGTC_1400 3771-8998 51.5 µM 0.382572555871518 0.389867142301984 no 1273 0.351018361084002 1708 670767 SGTC_1461 k072-0203 53.8 µM 0.381353041130381 0.390303688863638 no 1274 0.351470650343407 1606 5418714 SGTC_107 0358-0022 2.6945 µM 0.381336467504136 0.390309622636206 no 1275 0.351476798560938 1727 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.3800012964134 0.390787731101965 no 1276 0.351972226407093 1625 6312947 SGTC_2903 5923464 63.88 µM 0.379923738614785 0.390815508684643 no 1277 0.352001012694907 1690 2876576 SGTC_1895 st058434 18.3 µM 0.378898154352557 0.391182877430123 no 1278 0.352381747406371 1777 5393175 SGTC_933 2914-0560 114 µM 0.378105433033737 0.391466900211091 no 1279 0.352676136215558 1817 463887 SGTC_1038 k292-0204 154 µM 0.378103254514906 0.391467680828727 no 1280 0.35267694536248 1602 4454212 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.377586083574868 0.391653008437879 no 1281 0.352869052191513 1703 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2575 plumbagin 510 nM 0.377225224602712 0.391782336402666 no 1282 0.353003118051471 1590 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2640 pentamidine 10.38 µM 0.376806076649029 0.391932569522491 no 1283 0.353158862268806 1804 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_867 0518-0118 155 µM 0.376790903121136 0.391938008397113 no 1284 0.353164500809216 1682 6848158 SGTC_1926 methyl fluorone black 53.6 µM 0.376401356921767 0.392077646496653 no 1285 0.353309268685874 1584 72721 Reacts with homocysteine. SGTC_945 3381-0768 11.3 µM 0.375660308907631 0.392343323532257 no 1286 0.353584724511478 1705 1126236 YIL048W NEO1 SGTC_3311 9131146 2.8755 µM 0.374121770746525 0.392895073100676 no 1287 0.354156861088966 1649 4900406 YPR165W RHO1 SGTC_529 4076-0302 30.3 µM 0.373429792298676 0.393143300217333 no 1288 0.354414294758431 1653 5816522 SGTC_3022 9087993 49.47 µM 0.373304294593172 0.393188323522194 no 1289 0.354460990242879 1709 17173644 SGTC_836 0330-0104 1.35 µM 0.372862467099526 0.393346844031616 no 1290 0.354625403870998 1705 46494820 SGTC_2567 aureobasidin a 60 nM 0.372521138857987 0.39346931915426 no 1291 0.354752438087578 1724 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1982 st072467 71.9 µM 0.371976213344679 0.39366487072915 no 1292 0.354955279819692 1634 3163533 SGTC_2084 5306078 60.6385 µM 0.371438332945258 0.393857920403523 no 1293 0.355155539422219 1723 679340 SGTC_1864 st057645 30.4 µM 0.370560303282894 0.394173108459929 no 1294 0.355482526799692 1728 688666 SGTC_380 3970-0968 6 µM 0.370192590002918 0.394305127833652 no 1295 0.355619498674284 1652 2891601 SGTC_2363 9053361 176 µM 0.369090630627541 0.394700834800992 no 1296 0.356030086185284 1786 6469797 YMR079W SEC14 SGTC_254 nsc-64875 3.808 µM 0.368719230938027 0.39483422669387 no 1297 0.356168506504948 1799 56993 SGTC_105 0111-0055 734.78 µM 0.367576013810928 0.395244901815563 no 1298 0.356594701378792 1687 5179370 SGTC_433 pimozide 108 µM 0.36728516700541 0.395349400597676 no 1299 0.356703158568628 1559 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_293 4049-0273 38.5 µM 0.365956031089766 0.395827043491082 no 1300 0.357198942591358 1683 1380311 SGTC_53 0973-0023 39.979 µM 0.365606288341745 0.395952754291564 no 1301 0.357329441049613 1852 674768 SGTC_2725 haloperidol 53.21 µM 0.364773575545757 0.396252106369834 no 1302 0.357640215807479 1664 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1514 1189-1591 158 µM 0.364053737640227 0.396510930343149 no 1303 0.357908940886784 1750 767698 YMR146C TIF34 SGTC_2552 juarezic acid 87.02 µM 0.363535948150382 0.396697134263609 no 1304 0.35810228216005 1673 1549512 SGTC_707 0865-0008 204 µM 0.363474604297761 0.396719195882673 no 1305 0.3581251902103 1742 723043 SGTC_1462 k081-0014 26.5 µM 0.362695542719446 0.396999405258507 no 1306 0.358416164860361 1593 3270634 SGTC_2319 6033012 152.6 µM 0.362069659001255 0.397224558841945 no 1307 0.358649988108024 1600 847246 SGTC_3333 9141820 12.094 µM 0.361740925198329 0.397342830306853 no 1308 0.358772820659318 1656 1939433 SGTC_409 arachidonic acid 100 µM 0.361727366287461 0.39734770871879 no 1309 0.358777887308208 1695 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_907 3448-6986 75.5 µM 0.361653476591591 0.397374294054727 no 1310 0.358805498601628 1773 590582 SGTC_1280 0880-0253 10.1 µM 0.361314256117994 0.397496350886979 no 1311 0.358932268856365 1669 6836607 SGTC_889 0919-1524 82.7 µM 0.360637434110926 0.397739912011581 no 1312 0.359185250768828 1662 3905452 SGTC_1694 st024011 44.9 µM 0.360483794558631 0.397795206286361 no 1313 0.359242686624819 1710 2787533 SGTC_2372 9071633 200 µM 0.360191547606538 0.397900390489353 no 1314 0.359351947570285 1756 21321366 SGTC_920 mycophenolic acid 780.421 nM 0.359831435811809 0.398030010506191 no 1315 0.359486596631765 1642 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1713 st033146 12.748 µM 0.358573554971593 0.398482865179103 no 1316 0.359957066494931 1806 674619 SGTC_2853 9015042 58.44 µM 0.358448547504183 0.398527877093143 no 1317 0.360003833122111 1599 6457456 SGTC_2487 5918373 44.05 µM 0.356803117555097 0.399120478922686 no 1318 0.36061960110821 1784 2876279 SGTC_914 3820-6779 408 µM 0.35611703200485 0.399367641513597 no 1319 0.360876461287138 1633 2893481 SGTC_3318 9139014 38.6185 µM 0.354999689725381 0.399770250818161 no 1320 0.361294911838852 1694 16643984 SGTC_2630 antimycin a 100 µM 0.354741374683 0.399863344051572 no 1321 0.361391675822137 1627 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1839 st053978 48 µM 0.352466680076898 0.400683358272508 no 1322 0.362244151311588 1727 3788398 SGTC_2270 7924575 90.91 µM 0.351379348443678 0.401075489929094 no 1323 0.36265188671811 1854 1262135 SGTC_334 1502-1024 68.5 µM 0.350243009278389 0.401485402015025 no 1324 0.363078165817112 1720 3296216 SGTC_1193 1488-0126 41.5 µM 0.350220151139784 0.401493648754629 no 1325 0.363086742417554 1682 1384710 SGTC_2380 9035439 200 µM 0.349796837077176 0.401646379564564 no 1326 0.363245586459981 1782 6462575 SGTC_2904 7225135 42.03 µM 0.348891982186486 0.401972899632183 no 1327 0.363585202358116 1765 4446116 SGTC_787 4152-0075 138 µM 0.348416917977049 0.402144355631195 no 1328 0.363763549425462 1725 9566539 SGTC_2601 securinine 100 µM 0.348137061937909 0.402245367629293 no 1329 0.363868625894125 1664 442872 A GABA receptor antagonist. SGTC_443 clozapine 122 µM 0.346104230667251 0.402979298803113 no 1330 0.364632192042118 1812 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2953 9074162 66.49 µM 0.345625494108538 0.403152191170502 no 1331 0.364812091957605 1868 16451992 SGTC_2992 9074591 71.4286 µM 0.3452826199946 0.403276029402804 no 1332 0.3649409556986 1724 17741321 SGTC_2796 7949634 45.45 µM 0.34487992386914 0.403421486353924 no 1333 0.365092322064909 1666 2971588 SGTC_2238 6671620 73.2395 µM 0.344129442425412 0.403692601687891 no 1334 0.365374470876749 1619 729941 SGTC_3196 9111891 49.47 µM 0.343994433732842 0.403741379197439 no 1335 0.365425236089076 1707 18891510 SGTC_2724 maprotiline 69.64 µM 0.343719976201151 0.403840543018669 no 1336 0.365528443340136 1769 4011 A tricyclic antidepressant. SGTC_2300 7976697 71.57 µM 0.343061425082401 0.404078508289093 no 1337 0.365776125178192 1641 2236109 SGTC_3200 9114385 49.47 µM 0.342660386036364 0.404223439820689 no 1338 0.365926983850691 1641 17018030 YLR208W SEC13 SGTC_2556 citropten 84.59 µM 0.342071735560994 0.404436196065599 no 1339 0.366148453771229 1629 2775 A potential DNA crosslinker. SGTC_1952 st077036 64.1 µM 0.341724688156634 0.404561642835172 no 1340 0.366279045469837 1681 2937007 SGTC_928 2764-0428 58.7 µM 0.341656128291169 0.404586426240703 no 1341 0.366304845937316 1759 662578 SGTC_481 bay k-8644 50 µM 0.341402797402377 0.404678005034149 no 1342 0.366400184728672 1668 2303 A calcium channel antagonist. SGTC_2844 9010103 25.97 µM 0.341299054906044 0.404715509321697 no 1343 0.366439229660104 1710 2480525 SGTC_2034 5197015 53.07 µM 0.339840415392938 0.405242919368081 no 1344 0.366988355128954 1818 780676 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.339302218258514 0.405437562428339 no 1345 0.367191035868699 1822 94937 An inhibitor of serotonin biosynthesis. SGTC_1958 st076513 41.9 µM 0.336712173481197 0.406374597974543 no 1346 0.368166942805345 1689 732122 YGL099W LSG1 SGTC_2558 carylophyllene oxide 100 µM 0.335998869892914 0.40663275390632 no 1347 0.36843585933945 1750 6708694 An oxygenated terpenoid and antifungal agent. SGTC_755 1995-0008 37.3 µM 0.335937558706637 0.406654945296938 no 1348 0.368458976759697 1711 689533 SGTC_1211 1056-0033 32.3 µM 0.335641542507518 0.40676209164338 no 1349 0.368570596546127 1841 6741922 SGTC_1661 st013063 9.66 µM 0.334890538888493 0.407033957032488 no 1350 0.368853829652949 1718 721395 SGTC_3041 9091929 49.47 µM 0.332992262834295 0.407721337668651 no 1351 0.369570061782117 1774 25236887 SGTC_2322 7413319 38.22 µM 0.332845863696839 0.407774361773708 no 1352 0.369625317986161 1741 1840400 SGTC_1565 sinapyl alcohol 95.1 µM 0.331842485039396 0.408137819547686 no 1353 0.370004100934725 1664 5280507 A phenol propionate derived from cinnamic acid. SGTC_2776 terbinafine 19.92 µM 0.331825541729287 0.408143957668747 no 1354 0.370010498245001 1727 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2279 7948423 32.93 µM 0.331735784029174 0.408176474927538 no 1355 0.370044388790484 1897 1247112 SGTC_1068 loratadine 26.9 µM 0.329375863458125 0.4090316489558 no 1356 0.370935804536669 1707 3957 A H1 histamine antagonist. SGTC_1048 3161-0300 24.5 µM 0.327890169855007 0.409570248263004 no 1357 0.371497353274603 1699 2165101 SGTC_2371 9071574 200 µM 0.327297789018141 0.409785048082036 no 1358 0.37172133227061 1813 45596039 SGTC_2188 6126565 140.678 µM 0.327232197661269 0.409808833454191 no 1359 0.371746135012595 1818 874518 SGTC_1641 st009299 47.1 µM 0.327196215402314 0.409821881829898 no 1360 0.371759741584556 1807 4046054 SGTC_345 1362-0200 395 µM 0.326253903340305 0.410163631347671 no 1361 0.372116130750757 1670 1419823 SGTC_512 prima-1 270 µM 0.326103234788558 0.410218280838162 no 1362 0.372173124844229 1808 322968 A re-activator of the apoptotic function of mutant p53. SGTC_455 paf C-16 10 µM 0.319683626400958 0.412548364945426 no 1363 0.374604086596673 1733 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1383 3049-0032 20.7 µM 0.318560484809918 0.412956343883665 no 1364 0.375029910975946 1869 712864 SGTC_435 c-PAF 6.7 µM 0.318019604790308 0.413152851042682 no 1365 0.375235032921485 1873 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2696 st077691 74.316 µM 0.317834690110997 0.413220037402011 no 1366 0.375305167584809 1766 757133 SGTC_387 norethindrone acetate 66.7 µM 0.31759027315829 0.413308847042965 no 1367 0.375397876667163 1713 541197 SGTC_1615 st002656 86.5 µM 0.317523531146529 0.413333098726537 no 1368 0.375423193636349 1726 1584458 SGTC_382 3229-0966 23.2 µM 0.316235831413794 0.413801067837226 no 1369 0.375911756324536 1840 5722370 SGTC_3351 9150312 21.596 µM 0.315051843593819 0.414231454573391 no 1370 0.376361145568988 1779 4904905 SGTC_1632 st005650 90 µM 0.314202008746011 0.414540438220382 no 1371 0.376683808564906 1759 2759605 SGTC_3087 9117406 49.47 µM 0.313861043317931 0.414664421586015 no 1372 0.376813289629483 1759 42546093 SGTC_3289 9119912 71.43 µM 0.313248868871494 0.414887044508247 no 1373 0.377045796641216 1782 17014829 SGTC_1993 st073995 70.8 µM 0.312512575939684 0.415154840475988 no 1374 0.377325503554844 1785 3098394 SGTC_1376 2910-0861 41.3 µM 0.311499354095977 0.415523422261882 no 1375 0.377710516918355 1788 1112859 SGTC_2016 5121758 140 µM 0.311496938267557 0.4155243011617 no 1376 0.377711435052454 1744 2795203 SGTC_2292 7671323 168.05 µM 0.310079961645594 0.416039882510473 no 1377 0.378250075029809 1749 937504 SGTC_3232 9132874 49.47 µM 0.308047915992839 0.416779515022592 no 1378 0.379022936117809 1714 3784940 SGTC_582 0987-0078 156 µM 0.307160682164662 0.417102546696735 no 1379 0.379360535454907 1815 1625765 SGTC_2155 5570423 76 µM 0.306387463142004 0.417384112537671 no 1380 0.379654826323714 1761 797402 SGTC_108 0509-0257 621.132 µM 0.303456987378472 0.418451621618261 no 1381 0.380770811015687 1852 536624 SGTC_2675 theaflavin digallate 100 µM 0.302599780360892 0.418763997581719 no 1382 0.381097440936209 1798 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1060 3448-7350 82 µM 0.302191240952171 0.418912892015494 no 1383 0.381253140506576 1881 570178 SGTC_2245 6637752 200 µM 0.300878445129771 0.419391426201092 no 1384 0.381753593726797 1906 681890 SGTC_1435 4092-0789 56.7 µM 0.299623914417455 0.419848833302973 no 1385 0.382232020358268 1871 2248285 SGTC_215 1287-0124 461.5 µM 0.299328231729905 0.419956656230829 no 1386 0.382344807843017 1911 5560863 SGTC_2290 7904846 200 µM 0.298520690055597 0.420251162998485 no 1387 0.382652893603767 1731 2962154 SGTC_1394 3474-0001 65.7 µM 0.298468960741158 0.420270029967272 no 1388 0.382672631422292 1747 5017666 YIL048W NEO1 SGTC_1324 1418-0026 34.4 µM 0.297536431024956 0.420610178148182 no 1389 0.383028499341538 1826 1372513 SGTC_3265 9137266 49.47 µM 0.297292862617368 0.420699031580891 no 1390 0.383121465130624 1963 17224265 SGTC_1426 4048-4480 71.7 µM 0.297279395990362 0.420703944306506 no 1391 0.383126605302391 1859 14224343 SGTC_2881 9058953 51.95 µM 0.297204197081409 0.420731377654373 no 1392 0.383155308882172 1758 17122249 SGTC_2779 methotrexate 400 µM 0.297131544537956 0.420757882427129 no 1393 0.383183041118252 1860 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1987 st072290 61.9 µM 0.294793162840964 0.421611151469717 no 1394 0.38407594486452 1795 54697379 SGTC_1649 st011737 51.3 µM 0.294476817335894 0.421726613436766 no 1395 0.384196787789433 1778 1761035 SGTC_3181 9108277 49.47 µM 0.294274116825148 0.421800600007022 no 1396 0.384274224625115 1761 17097298 SGTC_1569 carminic acid 40.6 µM 0.294252468410967 0.421808501935783 no 1397 0.384282495152086 1921 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_447 ml7 120 µM 0.293968577057645 0.421912128569915 no 1398 0.384390957443737 1872 4216 Selective myosin light chain kinase inhibitor. SGTC_1448 4255-0083 152 µM 0.293228694883436 0.422182227348637 no 1399 0.38467367611703 1907 5399660 SGTC_3294 9122953 26.2835 µM 0.291875352209772 0.422676368473644 no 1400 0.385190964706754 1751 16459826 SGTC_1361 1608-0041 5.61 µM 0.290149579036533 0.423306670254007 no 1401 0.385850903881337 1774 X1361 SGTC_2900 5328528 85.29 µM 0.290029090993524 0.423350683287946 no 1402 0.385896991119165 1747 795359 SGTC_2732 terfenadine 20 µM 0.289759736310891 0.423449079221549 no 1403 0.386000026363984 1834 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_89 0302-0250 142.109 µM 0.289734656832303 0.423458241060322 no 1404 0.386009620332999 1830 4203518 YLR208W SEC13 SGTC_2863 9028737 58.44 µM 0.286470004968925 0.4246512096578 no 1405 0.387259081901409 1927 6460917 SGTC_1075 aripiprazole 15.2 µM 0.286278552693723 0.424721191660219 no 1406 0.387332391746599 1784 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2179 6298986 200 µM 0.286002471871328 0.424822112312815 no 1407 0.387438114160782 1936 738374 SGTC_952 1185-0122 232 µM 0.285933962932171 0.424847156347177 no 1408 0.387464350273018 1788 678600 SGTC_406 estrone 100 µM 0.284764304883029 0.425274781666685 no 1409 0.38791236050424 1926 5870 A steroid. SGTC_1986 st071812 45 µM 0.283461116830184 0.425751328903666 no 1410 0.388411692039874 1815 11838594 SGTC_1493 4348-0038 111 µM 0.283327926625242 0.425800039756243 no 1411 0.388462735807711 1852 800424 SGTC_2193 5925765 200 µM 0.282553511174234 0.426083284470357 no 1412 0.388759560649516 1890 877370 SGTC_3038 9091290 49.47 µM 0.280844620417385 0.426708450988677 no 1413 0.389414789085293 1900 25236843 SGTC_2830 7992007 71.43 µM 0.280745404155529 0.426744753120384 no 1414 0.389452840584245 1738 1952075 SGTC_400 oxethazaine 37.5 µM 0.28048745303346 0.426839137483042 no 1415 0.389551775161103 1804 4621 A local anesthetic. SGTC_856 0433-0016 11.3 µM 0.279864150430159 0.427067221299906 no 1416 0.389790866184962 1816 3911780 SGTC_178 4092-0806 87.505 µM 0.279427122775855 0.427227156461593 no 1417 0.389958529366251 1827 2169044 SGTC_3272 9137413 49.47 µM 0.277112444970519 0.428074437556573 no 1418 0.390846883092822 1738 17614870 SGTC_3231 9132313 49.47 µM 0.276358224775097 0.428350589514806 no 1419 0.391136469749333 1844 4905967 SGTC_286 k060-0067 22.9 µM 0.275768076272989 0.428566692353562 no 1420 0.391363102354201 1811 5985051 SGTC_136 0097-0015 404.482 µM 0.275732070186726 0.428579877894085 no 1421 0.391376930836534 1951 4861337 SGTC_2349 9023730 187.07 µM 0.275516186363477 0.428658936891529 no 1422 0.391459845965545 1911 4126287 SGTC_2682 pyrogallin 40.03 µM 0.273497370126492 0.429398387434224 no 1423 0.39223545682253 1872 822798 An ATP competetive kinase inhibitor. SGTC_1604 st002052 72.4 µM 0.272994394302136 0.429582655713391 no 1424 0.392428762335677 1836 6254834 YHR062C RPP1 SGTC_1000 4048-0884 8.67 µM 0.272024180141798 0.429938142931297 no 1425 0.392801713545252 1840 13040088 SGTC_6 0844-0013 19.835 µM 0.271483148148675 0.430136402160813 no 1426 0.393009729512551 1899 1584900 SGTC_2051 5263410 176 µM 0.271425152179299 0.430157655621604 no 1427 0.393032029615689 1931 227584 SGTC_257 daunorubicin 18.5 µM 0.270839990086907 0.430372108034595 no 1428 0.393257050655449 1955 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_236 1509-0011 5.31 µM 0.269022420135009 0.431038348630056 no 1429 0.393956214845952 1905 3107280 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.268401710813761 0.431265918217482 no 1430 0.394195061386383 1927 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_198 3454-2873 16.191 µM 0.268016553043734 0.431407139423727 no 1431 0.394343288616425 1848 710957 SGTC_561 1550-0330 72.9 µM 0.26654134600038 0.431948116952096 no 1432 0.394911160588175 1798 6812934 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.26620659662982 0.432070891685243 no 1433 0.395040051450837 1808 61125 An anti-inflammatory. SGTC_145 3737-0113 38.366 µM 0.265250278979434 0.432421672718508 no 1434 0.395408332275701 1956 6849351 SGTC_3035 9091303 49.47 µM 0.264957438136539 0.432529098545368 no 1435 0.395521124871709 1842 25237002 SGTC_1294 1000-1494 117 µM 0.263295015476263 0.433139036491114 no 1436 0.396161600634245 1796 712797 YDL207W GLE1 SGTC_1702 st027038 51 µM 0.263274390684594 0.433146604669479 no 1437 0.396169548439966 1867 5521182 SGTC_2876 9059903 25.97 µM 0.263055594174661 0.433226892614456 no 1438 0.396253864779967 1876 6916095 SGTC_1714 st033236 13.627 µM 0.262881558987389 0.433290757244467 no 1439 0.396320935174597 1917 2916566 SGTC_1761 st044296 37 µM 0.262754288780377 0.433337461918111 no 1440 0.39636998503187 1809 1826700 SGTC_2885 9057732 51.95 µM 0.262360826600747 0.433481857626691 no 1441 0.396521635477962 1841 6471414 SGTC_1650 st011916 45.8 µM 0.262219954199798 0.433533558199036 no 1442 0.396575935132478 1960 242528 SGTC_640 3381-0960 37.1 µM 0.259008326474366 0.434712541543205 no 1443 0.397814408033637 1913 1745025 SGTC_1027 k015-0025 8.67 µM 0.256679601039227 0.435567776749664 no 1444 0.398713060044083 1788 3598955 SGTC_1889 st059080 5.18 µM 0.25642954441484 0.435659629196115 no 1445 0.398809588585417 2003 176925 Isolated from Daphnopsis sellowiana. SGTC_1264 0783-0040 158 µM 0.255163869324624 0.436124598453133 no 1446 0.399298267840289 1772 2855798 SGTC_1685 st024049 53.0905 µM 0.254728519550881 0.436284552720083 no 1447 0.399466393632763 1889 1941139 SGTC_991 3996-0057 64.7 µM 0.253202858283371 0.436845186437983 no 1448 0.400055728939812 1865 715343 SGTC_191 3914-0123 66.505 µM 0.250295582599553 0.437913871376476 no 1449 0.401179386174362 1838 3144412 SGTC_1463 k081-0032 34.1 µM 0.249896351544904 0.438060660195931 no 1450 0.401333752389197 1885 977755 SGTC_3246 9135460 32.98 µM 0.247724417861662 0.438859383093345 no 1451 0.402173818949078 1934 41446951 SGTC_1616 st002734 56.1 µM 0.245809810202542 0.439563681666083 no 1452 0.402914731291487 1903 4026101 SGTC_1332 1480-0653 17.5 µM 0.242929510984381 0.440623574738874 no 1453 0.404030001884965 2010 5749438 SGTC_456 gingerol 170 µM 0.242213290309436 0.440887196120357 no 1454 0.404307448719947 1901 442793 A herb. SGTC_262 fenpropimorph 62.5 µM 0.2405452089189 0.441501272945627 no 1455 0.404953810102803 1850 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3052 9092717 49.47 µM 0.239734347269551 0.441799829265304 no 1456 0.405268102995794 1853 25237534 SGTC_127 0180-0333 59.125 µM 0.239314741659121 0.441954339524071 no 1457 0.405430767643183 2000 771601 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.238739382479007 0.442166216859207 no 1458 0.405653838394682 1863 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1335 1486-0900 202 µM 0.238365179268427 0.44230402693183 no 1459 0.405798936029528 1877 X1335 SGTC_1174 0739-0097 51.1 µM 0.2383118866305 0.442323653901325 no 1460 0.405819601351636 1886 728447 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.236711389693001 0.442913161385248 no 1461 0.406440349178088 1968 804 An inhibitor of viral and cellular DNA polymerases. SGTC_955 1216-0110 33 µM 0.236529620601766 0.442980120008116 no 1462 0.406510862664338 1836 3619719 SGTC_2474 5321570 43.32 µM 0.23606887320461 0.44314985368682 no 1463 0.406689613478942 1986 2841384 SGTC_1226 3909-7979 35.4 µM 0.235553031236974 0.443339895905148 no 1464 0.406889761762181 1984 6615510 SGTC_1477 0139-0234 16 µM 0.234825564167338 0.443607925428946 no 1465 0.407172062564124 1937 620880 SGTC_3284 9108171 64.8615 µM 0.234698208306105 0.443654851352185 no 1466 0.407221489232269 1899 8687505 SGTC_253 dyclonine 31.25 µM 0.234642976092887 0.443675202625065 no 1467 0.40724292525215 1930 3180 An oral anasthetic. SGTC_2215 7188065 200 µM 0.234637744367361 0.443677130353343 no 1468 0.407244955736924 1974 940217 SGTC_1184 1269-1718 139 µM 0.23416581204913 0.443851028224216 no 1469 0.407428127616179 1998 5403821 SGTC_1041 0206-0046 107 µM 0.234046189175852 0.443895108642927 no 1470 0.407474560259319 1871 50494 SGTC_1372 2752-0194 270 µM 0.233880769801071 0.443956065982372 no 1471 0.407538771348569 1885 823334 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.232675108255559 0.444400394407444 no 1472 0.408006849750232 1936 5393153 SGTC_3099 9120367 49.47 µM 0.232651556719322 0.444409074669527 no 1473 0.408015994559315 1899 24824940 SGTC_3104 9120930 49.47 µM 0.231650461684138 0.444778067443072 no 1474 0.408404755301913 1920 17014836 SGTC_973 1325-0077 65.9 µM 0.231135936901975 0.44496773433794 no 1475 0.408604598644309 1973 2835149 SGTC_2247 cerulenin 830 nM 0.230226802504462 0.445302895126095 no 1476 0.408957767900857 1981 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_509 pifithrin 175 µM 0.229521374424454 0.445562984652018 no 1477 0.409231854804616 1937 4817 A p53 inhibitor. SGTC_1803 st050068 52.4 µM 0.22944855256179 0.445589835222327 no 1478 0.409260151527924 1944 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_913 3487-1245 167 µM 0.228628718960377 0.445892138004587 no 1479 0.409578750600483 1839 4016153 SGTC_547 1120-0019 610 nM 0.228181095624897 0.446057206468838 no 1480 0.409752728655001 1878 3676939 SGTC_1743 st037606 46.3785 µM 0.225968619195291 0.446873230294625 no 1481 0.4106129136714 1897 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2181 6316240 54.2555 µM 0.224677134676391 0.447349670500538 no 1482 0.411115226870101 1850 12779990 SGTC_1415 3966-0071 78.1 µM 0.224489160432312 0.447419022233633 no 1483 0.411188350211545 1941 2893185 SGTC_866 0495-0101 262 µM 0.223849490247316 0.447655035937096 no 1484 0.411437209645544 1809 635694 SGTC_3239 9133757 49.47 µM 0.22384309852542 0.447657394330381 no 1485 0.411439696482451 1969 17036923 SGTC_87 0100-0052 35.5 µM 0.222026651180925 0.448327694848652 no 1486 0.412146568212431 1936 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_445 e6 berbamine 66 µM 0.221849885825754 0.448392932233726 no 1487 0.41221537183135 1911 6610268 A calcium/calmodulin antagonist. SGTC_3321 9137793 26.8275 µM 0.221060641752834 0.448684229274594 no 1488 0.412522607727174 2009 4904192 SGTC_858 0438-0351 2.77 µM 0.22101435760747 0.448701312853751 no 1489 0.412540626824325 1898 2799119 SGTC_2020 4017018 200 µM 0.220394033708857 0.448930284927487 no 1490 0.412782145798808 1906 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_831 k061-1017 217 µM 0.219992887014363 0.449078364038682 no 1491 0.412938347177296 2004 1240153 SGTC_2499 avocadenofuran 51.48 µM 0.219736862389634 0.449172876563447 no 1492 0.413038047091142 1815 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2827 7993847 71.43 µM 0.217183197473786 0.450115729258517 no 1493 0.414032789326789 1921 2985692 SGTC_2646 retinol 96.75 µM 0.215678421205531 0.450671448215599 no 1494 0.414619211367543 1964 445354 A vitamin A analog and teratogen. SGTC_3307 9126885 69.2785 µM 0.214583175583547 0.451075987000967 no 1495 0.415046156162189 1860 24824909 SGTC_2297 7971671 152.32 µM 0.213599009261665 0.451439541015307 no 1496 0.415429886031396 2004 909016 SGTC_2200 6600604 21.907 µM 0.213220453325406 0.451579391586492 no 1497 0.415577507809644 1937 2904777 SGTC_2908 7930301 100 µM 0.211041198264733 0.45238459388186 no 1498 0.416427561843146 1954 2223178 SGTC_660 4031-1742 102 µM 0.210482487470189 0.452591060878915 no 1499 0.416645559247103 1908 6738706 SGTC_2546 rhodinyl acetate 100 µM 0.2088864337698 0.453180939878686 no 1500 0.417268447418875 2065 6708682 SGTC_2741 miltefosine 3.04 µM 0.20832301866434 0.453389194919048 no 1501 0.417488379803078 1958 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_290 2043-6722 48.1 µM 0.207930531426733 0.45353427749622 no 1502 0.417641604753292 1989 773758 YLR208W SEC13 SGTC_2662 daunorubicin 22.37 µM 0.207166224891634 0.453816820543579 no 1503 0.417940021864989 1996 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1862 st057513 3.81 µM 0.207054297915856 0.453858198825349 no 1504 0.417983726789849 1933 5393163 SGTC_2098 5376439 882.5 nM 0.205347182883521 0.454489363965974 no 1505 0.418650441402311 2022 2844116 SGTC_3298 9116858 71.43 µM 0.205014162614221 0.454612503728749 no 1506 0.418780529938341 2007 2506942 SGTC_2582 agaric acid 100 µM 0.20462548555455 0.45475622902768 no 1507 0.41893237105646 1907 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3157 9099274 49.47 µM 0.202508016334164 0.455539331956277 no 1508 0.419759796055271 2056 17217662 SGTC_2516 gossypol 71.55 µM 0.20083214456876 0.456159241684912 no 1509 0.420414913621322 2032 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_531 3788-1495 174 µM 0.200601885328464 0.456244423605742 no 1510 0.420504941880376 1900 2896655 SGTC_3290 9121031 71.43 µM 0.199805588505081 0.456539020499564 no 1511 0.420816315233129 1913 17014854 SGTC_1303 1160-0052 261 µM 0.197189007837929 0.457507214502336 no 1512 0.421839816107693 2059 3562476 SGTC_2842 9000675 19.48 µM 0.195260210299208 0.458221075024013 no 1513 0.422594622528393 1844 2989072 SGTC_2736 butenafine 14.65 µM 0.194487428248917 0.458507124636712 no 1514 0.422897119297241 2045 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2404 5161160 200 µM 0.193304424781195 0.458945061585746 no 1515 0.423360280605225 1960 2831543 SGTC_408 cantharidin 100 µM 0.192845337564767 0.459115024879834 no 1516 0.42354004781044 1980 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_719 2810-4230 27.3 µM 0.192832867679384 0.45911964158587 no 1517 0.423544930931492 1993 721079 SGTC_783 0848-0141 92.7 µM 0.192719730552057 0.459161528418278 no 1518 0.423589235186163 1945 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_609 0986-0026 86.3 µM 0.192694915144333 0.459170715903501 no 1519 0.423598952975422 1980 2848610 SGTC_2545 solidagenone 89.61 µM 0.192245314743764 0.459337176623417 no 1520 0.423775025903913 1996 6708572 An anti ulcer agent SGTC_868 0527-0199 213 µM 0.191627640186069 0.459565876987875 no 1521 0.424016945000557 1963 2849450 SGTC_2446 5162541 200 µM 0.190241138110857 0.460079292270769 no 1522 0.424560088078718 1926 1549321 SGTC_1749 st037932 54.2 µM 0.189570480942731 0.460327657447636 no 1523 0.424822860258472 1944 594497 SGTC_2678 equilin 100 µM 0.189106996096499 0.460499309330926 no 1524 0.425004479164616 2072 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1093 fluphenazine 7.97 µM 0.188800539502635 0.460612809753998 no 1525 0.425124574492503 1960 6602611 An atypical antipsychotic. SGTC_2893 9048488 25.97 µM 0.18761116933804 0.461053339697675 no 1526 0.425590734929682 1909 6467338 SGTC_43 0570-0105 72.5 µM 0.187244675250769 0.4611890948327 no 1527 0.425734399216554 1980 1114046 YDL195W SEC31 SGTC_1550 gossypolone 36.6 µM 0.18520366108204 0.461945200655246 no 1528 0.426534648820291 2088 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_996 3970-0799 1.8 µM 0.184867149158028 0.462069876778306 no 1529 0.426666619001287 2076 6615648 YGL040C HEM2 SGTC_2101 5377231 179.231 µM 0.184651398327238 0.46214981343227 no 1530 0.426751234517027 2033 2844213 SGTC_2341 7987486 176.74 µM 0.183732908056433 0.462490135281289 no 1531 0.427111495733738 2090 1258686 SGTC_3009 9080819 71.4286 µM 0.183694159168831 0.462504493244097 no 1532 0.42712669562363 1953 17027216 SGTC_1129 3453-1384 223 µM 0.183661560054378 0.462516572515739 no 1533 0.427139483247431 1994 1084452 SGTC_1235 benzylparaben 21.5 µM 0.183449580556651 0.462595120214054 no 1534 0.427222638111584 2019 7180 SGTC_422 cantharidin 155 µM 0.182596122858599 0.462911378438628 no 1535 0.427557463354719 1876 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1241 0364-0022 50.8 µM 0.182133190242781 0.463082933078699 no 1536 0.427739101142949 2007 4563895 SGTC_683 panaxydol 45 µM 0.181978682561052 0.463140192422771 no 1537 0.42779972770404 2062 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1173 0443-0020 122 µM 0.1818929227873 0.463171974656973 no 1538 0.427833379324374 1938 5331295 SGTC_94 0334-0113 514.748 µM 0.181059501423046 0.463480849542381 no 1539 0.428160436166441 1904 6795178 SGTC_2589 lobaric acid 100 µM 0.180991381861616 0.463506096357323 no 1540 0.428187170289829 1932 73157 A novel microtubule depolymerizer. SGTC_1242 0402-0103 60.1 µM 0.180844071631167 0.463560693719312 no 1541 0.42824498461748 2016 432868 SGTC_799 1310-0557 151 µM 0.179526500958174 0.464049053292846 no 1542 0.428762155294071 2006 5354492 SGTC_1311 1190-0148 100 µM 0.178939187749802 0.464266759325843 no 1543 0.428992725984614 2055 1961333 SGTC_1954 st077032 68.9 µM 0.178727157461522 0.464345357624014 no 1544 0.429075971973561 1872 698907 SGTC_1403 3909-7815 62.9 µM 0.177480513857532 0.464807508629579 no 1545 0.429565484972935 1996 6615483 SGTC_235 0330-0087 5 mM 0.177267600423364 0.464886443857299 no 1546 0.429649099423403 1982 46494818 YHR062C RPP1 SGTC_678 1218-2179 85.9 µM 0.177082504503586 0.464955067181701 no 1547 0.429721792063429 2091 6820081 YOR116C RPO31 SGTC_218 alverine citrate 93.75 µM 0.175790822918098 0.465433980139451 no 1548 0.43022913980759 2080 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1363 1636-0063 10.4 µM 0.174807394338884 0.465798636650905 no 1549 0.430615488981113 1986 6072185 SGTC_144 4161-2749 112.381 µM 0.174763290047306 0.465814991250907 no 1550 0.430632817326134 2028 797501 YMR168C CEP3 SGTC_1 0258-0098 57.368 µM 0.174424207891239 0.465940730442795 no 1551 0.43076604538657 1986 6790032 YDR047W HEM12 SGTC_1786 berberine 21.6 µM 0.173367747029018 0.466332511329116 no 1552 0.431181187667808 2052 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.172406062190669 0.466689173588785 no 1553 0.431559153301242 2022 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_414 piperonyl butoxide 100 µM 0.172076211335435 0.466811512306867 no 1554 0.431688807196541 1967 5794 A potent inhibitor of cytochrome P450. SGTC_1104 tacrolimus 29.8 µM 0.171266168973778 0.467111963021058 no 1555 0.432007240322106 2049 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1481 3346-2004 36 µM 0.171042645898542 0.467194872692134 no 1556 0.432095116539419 2103 2770522 SGTC_775 4577-0580 57.3 µM 0.171003952712777 0.467209224998386 no 1557 0.432110328781266 2051 2006902 SGTC_2111 5486399 200 µM 0.170478478199573 0.467404141338578 no 1558 0.432316929257824 2026 689674 SGTC_1026 k007-1105 30.6 µM 0.169983515371803 0.467587747007962 no 1559 0.4325115504033 1950 7066794 SGTC_2388 9080168 200 µM 0.16989019963703 0.467622363104319 no 1560 0.43254824431837 1916 15943073 SGTC_1388 3346-4487 254 µM 0.169825068730766 0.467646523995007 no 1561 0.432573855648732 2056 3345614 SGTC_2480 5767542 37.17 µM 0.167635174577353 0.468458953581192 no 1562 0.433435148723702 2048 2867358 SGTC_1667 st014849 34.6 µM 0.167462006974209 0.468523202739073 no 1563 0.433503269696086 2095 5348460 SGTC_1266 0828-0227 32.9 µM 0.166408565180483 0.468914071441184 no 1564 0.433917716947577 2029 3913820 SGTC_113 0099-0221 2.5 µM 0.166223782835514 0.46898263612221 no 1565 0.433990421903325 2093 89219 SGTC_471 1-acyl-paf 4 µM 0.165445091818776 0.469271584529477 no 1566 0.434296832259925 1958 16759367 SGTC_368 fentichlor 4.58 µM 0.165385820145599 0.469293579098361 no 1567 0.434320156935442 1976 7329 A pesticide. SGTC_1596 piperlongumine 63 µM 0.16408069251663 0.469777910289934 no 1568 0.434833810474588 2131 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1557 sumaresinolic acid 42.3 µM 0.163563649562085 0.469969796675173 no 1569 0.435037331345498 1991 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_390 dec-rvkr-cmk 16.7 µM 0.162956875828789 0.470194993081961 no 1570 0.435276194414444 2042 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_485 niflumic acid 177 µM 0.162677838690326 0.470298557395636 no 1571 0.435386048347652 2076 4488 A COX2 inhibitor. SGTC_186 3455-3465 67.277 µM 0.161084093051114 0.470890112557864 no 1572 0.43601358426797 2073 755278 SGTC_728 3030-5151 22.5 µM 0.159222119520972 0.471581307913588 no 1573 0.436746938654545 2033 3125388 SGTC_697 0508-1955 564 µM 0.15826301351647 0.47193737745422 no 1574 0.437124775861527 2127 6243113 SGTC_1347 1493-0251 600 nM 0.155144352293072 0.473095338680763 no 1575 0.438353758696772 2125 3986378 SGTC_2347 9049783 174.81 µM 0.154942845335577 0.473170166289648 no 1576 0.438433187901287 2089 6467988 YPL169C MEX67 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.15357613985202 0.473677703660344 no 1577 0.438971975679813 2109 3256 An antibiotic and ribosome inhibitor. SGTC_1223 0764-0573 147 µM 0.151017347523007 0.474628046577397 no 1578 0.439981015748583 2082 1609797 SGTC_2522 biochanin a 4.94 µM 0.150883054172731 0.474677927553375 no 1579 0.440033984125463 2101 5280373 A possible chelator. SGTC_1962 st076595 64.5 µM 0.148987258307451 0.475382130603936 no 1580 0.440781843572957 2065 279619 SGTC_2167 5876490 200 µM 0.147724726304255 0.475851147360453 no 1581 0.441280008480328 2124 686534 SGTC_3165 9101544 49.47 µM 0.147357030734785 0.47598774854187 no 1582 0.441425109856594 2103 5002184 SGTC_1192 1488-0095 21.4 µM 0.146009544017716 0.476488372203201 no 1583 0.441956927069023 2043 915875 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.145423312042972 0.47670618308578 no 1584 0.442188329978179 2015 442882 SGTC_965 1291-5240 308 µM 0.144809496715989 0.476934249850499 no 1585 0.442430641984616 2120 2834598 SGTC_265 mycophenolic acid 32.932 µM 0.142257986246246 0.477882358999364 no 1586 0.443438115531736 2132 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_302 1094-0063 18.9 µM 0.141218373156069 0.478268702328126 no 1587 0.443848715924487 2047 5440289 SGTC_1574 spiramycin 23.7 µM 0.139993333718892 0.4787239803911 no 1588 0.444332628721279 2137 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2071 5230951 39.92 µM 0.1392549058645 0.478998425824466 no 1589 0.444624361255035 2142 1799272 SGTC_2424 5537928 59.2 µM 0.13900770536773 0.479090303039852 no 1590 0.444722030082016 2047 5382802 SGTC_1686 st019653 115.5 µM 0.138888827557597 0.479134486850902 no 1591 0.444768999857302 2161 97252 SGTC_2835 9006588 71.43 µM 0.138048721367714 0.479446739896704 no 1592 0.445100956025791 2001 2345538 SGTC_737 1950-0117 57.9 µM 0.137832545952827 0.479527090634811 no 1593 0.445186380943932 2180 5393513 SGTC_1944 st076371 56.9 µM 0.137340458031216 0.479709999025602 no 1594 0.445380846262629 1983 24208455 SGTC_1078 idebenone 36.1 µM 0.135943195918445 0.480229382555802 no 1595 0.445933093510965 2092 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1244 0416-0015 52.5 µM 0.135717874870323 0.480313140974554 no 1596 0.446022158183476 2059 96201 SGTC_2564 betulinic acid 100 µM 0.135694668614537 0.480321767467482 no 1597 0.446031331283209 2204 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2813 7971799 71.43 µM 0.135566561444152 0.480369389085381 no 1598 0.44608197072813 2069 2234054 SGTC_2641 levomentholum 100 µM 0.133756027973502 0.481042453132971 no 1599 0.446797749625375 2144 16666 SGTC_2515 chrysin 20.77 µM 0.130900522911337 0.48210409343673 no 1600 0.447927000509695 2136 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1760 st045453 10.4495 µM 0.129974564216613 0.48244838066501 no 1601 0.448293275387149 2180 3323419 YIL048W NEO1 SGTC_1071 trifluoperazine 6.31 µM 0.128103388067824 0.483144155541589 no 1602 0.449033577425876 2134 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_691 1548-0686 185 µM 0.12770486561818 0.483292348137121 no 1603 0.449191269709094 2056 46495133 SGTC_425 3825-7017 13.1 µM 0.127021268118513 0.483546552700808 no 1604 0.449461782684638 2120 3397440 SGTC_1770 st043884 66.3 µM 0.126334146206734 0.483802074602488 no 1605 0.449733714011176 2184 670149 SGTC_3276 9139060 49.47 µM 0.126302760181749 0.483813746368978 no 1606 0.44974613572456 2217 4870619 SGTC_1921 5740136 50 µM 0.125650528005206 0.484056300171744 no 1607 0.450004282156468 2193 1774243 SGTC_2431 5490079 200 µM 0.124855378074139 0.484352010573897 no 1608 0.450319022495751 2081 5722345 SGTC_1530 rhein 70.4 µM 0.124702504207967 0.484408864230049 no 1609 0.450379537403941 2182 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2382 9035899 200 µM 0.122839976822721 0.485101561633891 no 1610 0.451116908522254 2062 6462679 SGTC_2386 9075165 157.42 µM 0.122371936937916 0.485275638715519 no 1611 0.451302231265594 2098 16452277 SGTC_1356 1502-0781 85.8 µM 0.121922844415004 0.485442671383437 no 1612 0.451480061685121 2076 567702 SGTC_3156 9099931 49.47 µM 0.121818300625469 0.485481555115109 no 1613 0.45152146004528 2109 18111053 SGTC_680 0417-1641 114 µM 0.120335711242961 0.486033000048141 no 1614 0.452108608080007 2089 2835990 SGTC_1563 conessine 56.1 µM 0.119492449279712 0.486346660937182 no 1615 0.452442610889696 2195 441082 An anti-amoebic, histamine inhibitor. SGTC_523 1934-0222 13.7 µM 0.119084646680524 0.486498350799529 no 1616 0.45260414717802 2044 1361595 SGTC_396 dithiazanine 1.25 µM 0.117913562675112 0.48693396834981 no 1617 0.453068073379368 2039 10578 An antihelmenthic. SGTC_516 3992-2719 87.3 µM 0.117204699199227 0.487197657614508 no 1618 0.453348921582448 2170 5350887 YDR037W KRS1 SGTC_2077 5212015 200 µM 0.117091124539149 0.487239906637792 no 1619 0.453393921473484 2209 780900 SGTC_2043 5101342 149 µM 0.116974064105444 0.4872834524957 no 1620 0.453440303103732 2116 678451 SGTC_1364 1653-0028 37.6 µM 0.116519754131093 0.48745245481793 no 1621 0.453620315598862 2116 5718652 SGTC_2187 6125751 200 µM 0.115742537902193 0.487741582772566 no 1622 0.453928296206554 2147 874498 SGTC_1287 0971-0001 34.6 µM 0.115580757305678 0.487801766701818 no 1623 0.453992407063976 2125 4665869 SGTC_207 4185-0010 4.486 µM 0.115288152728413 0.487910619107793 no 1624 0.454108364250172 2205 3761753 SGTC_2587 piperic acid 92.2 µM 0.114963625808134 0.488031348060551 no 1625 0.454236976616612 2098 5370536 SGTC_1268 0828-0275 2.46 µM 0.114649205788175 0.488148318138759 no 1626 0.454361588122092 2154 745337 SGTC_2687 chenodiol 100 µM 0.113449270137347 0.488594725735632 no 1627 0.454837189947664 2135 5702181 A cholesterol synthesis inhibitor. SGTC_976 1348-1067 47.6 µM 0.113031943793459 0.488749985480493 no 1628 0.455002615003442 2194 5310671 YGL099W LSG1 SGTC_843 0310-0051 143 µM 0.112998150426282 0.488762557849607 no 1629 0.455016010784517 2093 2065037 SGTC_1358 1509-0022 2.48 µM 0.112875297138221 0.488808263862052 no 1630 0.455064710587172 2115 3258434 SGTC_2069 5228469 200 µM 0.112634202332093 0.488897960562914 no 1631 0.455160284020767 2110 2835210 SGTC_735 3076-0345 636 µM 0.112420858031057 0.488977333458559 no 1632 0.455244858921408 2200 2888990 SGTC_793 0488-0545 106 µM 0.112387978485558 0.488989566047012 no 1633 0.455257893358176 2024 292548 SGTC_2581 avocatin a 64 µM 0.112276284704708 0.489031120958258 no 1634 0.455302172478421 2121 6710728 A skin care supplement. SGTC_1447 4239-0816 81.9 µM 0.111492098698021 0.489322875353925 no 1635 0.455613065431607 2038 1341554 SGTC_179 1273-0063 6.77 µM 0.111176723330664 0.489440211571397 no 1636 0.455738104640461 2123 3108139 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.111023684998307 0.489497150206974 no 1637 0.455798782462814 2135 676296 Flavone; oxidizing agent. SGTC_1558 st069300 45.6 µM 0.109806857170895 0.48994988427827 no 1638 0.456281276349121 2219 24208000 SGTC_1692 fluoroquinolonic acid 71 µM 0.109793612724967 0.489954812091197 no 1639 0.456286528363584 2163 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2164 5685496 200 µM 0.108691510856555 0.490364872433565 no 1640 0.456723587658918 2203 759046 SGTC_50 0929-0078 56.389 µM 0.108608778197627 0.490395655287901 no 1641 0.456756398975449 2146 1377751 SGTC_3340 9146634 11.102 µM 0.107606750321347 0.490768490512612 no 1642 0.457153821052776 2117 4907387 SGTC_330 1488-0319 80.1 µM 0.107402369250998 0.490844537763494 no 1643 0.457234887495026 2110 6846614 SGTC_2136 5328288 199.296 µM 0.105561221637154 0.49152961692727 no 1644 0.457965246718553 2130 262395 SGTC_3312 9133330 71.43 µM 0.104256015542405 0.492015290959124 no 1645 0.458483091072326 2198 17617324 SGTC_1070 indatraline 8.81 µM 0.103884779130572 0.492153432168203 no 1646 0.458630393120129 2103 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3061 glucosamine 200 µM 0.10359690105959 0.492260555457674 no 1647 0.458744623514055 2211 91431 and experimental redox chemotherapeutic SGTC_2244 6635614 200 µM 0.102508089781044 0.492665721714003 no 1648 0.459176695980033 2064 836499 SGTC_1136 pergolide 1.05886 µM 0.102234310969873 0.492767600939811 no 1649 0.4592853471043 2082 47811 A dopamine receptor agonist. SGTC_2118 5526350 200 µM 0.100677540614328 0.493346918817629 no 1650 0.459903220381742 2142 743594 SGTC_2022 5136654 200 µM 0.100096140159393 0.493563277884976 no 1651 0.460133999825293 2131 1713771 SGTC_363 0455-0021 3.06 µM 0.0999225993129306 0.493627858761016 no 1652 0.460202887241754 2190 4597466 SGTC_2972 9093619 59.92 µM 0.0997350812889871 0.493697641242065 no 1653 0.460277324271909 2031 25236256 SGTC_1916 st067606 49.2 µM 0.0984989038766219 0.494157673890734 no 1654 0.460768071154043 2193 19590279 SGTC_2588 indole-3-carbinol 100 µM 0.0977496595692116 0.494436502449707 no 1655 0.461065540852166 2230 3712 Induces cell cycle arrest. SGTC_1149 3909-7961 23.3 µM 0.0977395423694325 0.494440267547916 no 1656 0.461069557796056 2073 735261 SGTC_1339 1486-1321 22.7 µM 0.0976313528636975 0.494480530114221 no 1657 0.461112513722136 2110 3469382 SGTC_1608 st001473 40.5 µM 0.0970401885817065 0.494700532019241 no 1658 0.461347239581651 2062 7292267 SGTC_412 gemfibrozil 100 µM 0.0963350261693067 0.49496296045355 no 1659 0.461627246790307 2231 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_688 0527-0193 473 µM 0.0961920466490364 0.495016171006201 no 1660 0.461684023689397 2154 4007154 SGTC_929 2805-0021 398 µM 0.0946774691474601 0.495579833953398 no 1661 0.462285507294153 2129 3098024 SGTC_693 4161-2696 114 µM 0.0924755533978925 0.496399311134372 no 1662 0.463160106770722 2195 805759 SGTC_2280 7785178 200 µM 0.0920048485833125 0.496574493338249 no 1663 0.463347093660678 2172 2954328 SGTC_3080 9117754 49.47 µM 0.0915685847410064 0.496736858236544 no 1664 0.463520406149951 2256 9550191 SGTC_3083 9117465 49.47 µM 0.0913729146416017 0.496809681216609 no 1665 0.463598141343091 2087 16420915 SGTC_375 3970-0961 9.27 µM 0.0913400938510762 0.49682189621436 no 1666 0.463611180418287 2172 2898222 SGTC_2339 9000433 200 µM 0.0912186744087086 0.496867085225316 no 1667 0.4636594183907 2104 2988954 SGTC_2981 9013952 38.96 µM 0.0902414771552386 0.497230772854123 no 1668 0.464047662380927 2021 2996344 SGTC_2706 st078239 82.5 µM 0.0898836629152109 0.497363942682611 no 1669 0.464189831851022 2272 15434492 SGTC_2922 7999257 32.47 µM 0.0893785844377599 0.497551921204261 no 1670 0.464390521244182 2255 2988377 SGTC_1089 terbinafine 2.25 µM 0.0883920061667112 0.497919104336581 no 1671 0.464782557291569 2236 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_428 3448-4153 16.5 µM 0.0883530499395646 0.497933603041484 no 1672 0.464798038009574 2172 3834874 SGTC_1628 st004252 77.7 µM 0.0882366779224814 0.497976914324134 no 1673 0.464844283112611 2220 692968 SGTC_797 k781-0471 270 µM 0.0880115180878609 0.498060714272859 no 1674 0.464933760779526 2193 23738129 SGTC_2054 5233173 129 µM 0.0854132503306412 0.499027742373378 no 1675 0.465966429709044 2195 6889 SGTC_2353 9059630 146.67 µM 0.0848772549080058 0.499227231039169 no 1676 0.466179487238177 2209 4779114 SGTC_1341 1486-1360 280 µM 0.0835263995274569 0.49972999790152 no 1677 0.466716493472215 2231 3976547 SGTC_1017 4239-0030 168 µM 0.0829793610451544 0.499933597080934 no 1678 0.46693397525395 2084 1149593 SGTC_1399 3562-5772 25 µM 0.0826225329998189 0.499933597080934 no 1679 0.467075841894196 2238 23847490 SGTC_2918 7977171 22.06 µM 0.0798815618537268 0.498913451670368 no 1680 0.46816572723491 2271 2236483 SGTC_259 usnic acid 108.925 µM 0.0787385183606279 0.498488030968248 no 1681 0.468620303675795 2241 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2152 5568786 200 µM 0.0785769595902673 0.498427901760406 no 1682 0.468684557222597 2263 5399883 SGTC_3291 9121177 71.43 µM 0.0764657200879997 0.497642140971371 no 1683 0.469524292754214 2191 17015612 SGTC_2771 fluoxetine 41.05 µM 0.0756890611334943 0.497353086302478 no 1684 0.469833239489755 2234 3386 A selective serotonin reuptake inhibitor. SGTC_1734 st037168 69.4 µM 0.0752190846352131 0.497178172482575 no 1685 0.470020200012992 2091 708907 SGTC_1130 3454-2858 15.9 µM 0.074533188206055 0.49692289949971 no 1686 0.470293067114181 2113 715628 YIL048W NEO1 SGTC_2444 5485484 36.41 µM 0.0727396731984275 0.496255405633678 no 1687 0.471006638752705 2238 6790631 SGTC_2969 9091408 28.7 µM 0.0721478632488961 0.496035153476281 no 1688 0.471242118039316 2062 4286311 SGTC_395 anisomycin 6.25 µM 0.0705364762631803 0.495435454671617 no 1689 0.471883334489356 2167 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2757 clomiphene 4.22 µM 0.0702937438239133 0.495345119470911 no 1690 0.471979930948355 2289 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_407 eburnamonine 100 µM 0.0697451237242922 0.49514094613604 no 1691 0.47219826283254 2243 3195 SGTC_1879 gemcitabine 100 µM 0.0691540218211675 0.494920964286041 no 1692 0.472433510357657 2260 60750 A nucleoside analog which inhibits DNA replication. SGTC_2606 farnesol 9.78 µM 0.0679758634982863 0.494482510808166 no 1693 0.472902423985198 2269 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2473 5854593 8.94 µM 0.06792218906364 0.494462535937397 no 1694 0.472923787610902 2231 2872951 SGTC_343 4130-2827 29.8 µM 0.0668805614695491 0.494074898398313 no 1695 0.47333839404232 2192 1118244 SGTC_1123 mangostin 811.285 nM 0.0664785171679856 0.493925280697482 no 1696 0.473498430342408 2162 5281650 An antioxidant. SGTC_1051 3253-3903 78 µM 0.0651030319071386 0.493413411006964 no 1697 0.47404598322165 2291 5509239 SGTC_919 tnp00227 403.569 nM 0.0646843701242042 0.493257613358284 no 1698 0.474212653796175 2235 1269246 A methoxyflavone. YNL221C POP1 SGTC_2334 9017922 200 µM 0.0634862854354745 0.492811772892971 no 1699 0.474689639925057 2273 3163164 SGTC_2037 5169046 200 µM 0.0612885320804988 0.491993951800887 no 1700 0.475564711853766 2246 5718022 SGTC_788 1182-0090 188 µM 0.0608487240581423 0.491830295748682 no 1701 0.475739842998015 2271 5715185 SGTC_272 doxorubicin 8.13 µM 0.0584575306612655 0.490940538503401 no 1702 0.476692095117516 2297 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_320 4092-0846 5.34 µM 0.0583829661739986 0.490912793940854 no 1703 0.476721791325362 2289 1359356 SGTC_1806 st050005 60.3 µM 0.0583697799508221 0.490907887507963 no 1704 0.476727042911498 2223 5194765 SGTC_2057 5236571 38.335 µM 0.0576352838781047 0.490634592667408 no 1705 0.477019571952219 2278 54684039 YBR257W POP4 SGTC_1524 corynanthine 62.1 µM 0.0563377150064952 0.490151797809107 no 1706 0.477536387150348 2213 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_170 4197-0004 226 µM 0.0557569327060734 0.489935707007334 no 1707 0.477767722130377 2255 218692 SGTC_2407 paclitaxel 400 µM 0.055603151021237 0.489878490177928 no 1708 0.477828977119304 2206 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_118 0083-0097 135.343 µM 0.0552028462408407 0.489729551637594 no 1709 0.477988430711516 2315 5207356 SGTC_1846 st056244 14.8 µM 0.055132805871551 0.489703492364297 no 1710 0.478016330287808 2244 5393182 SGTC_3185 9108267 49.47 µM 0.0547604614005124 0.489564958336596 no 1711 0.478164650171549 2219 4910486 SGTC_753 1322-0200 289 µM 0.0540284988238717 0.489292628922582 no 1712 0.478456229309049 2251 5403907 SGTC_1840 st055363 71 µM 0.0539613909369174 0.489267661430156 no 1713 0.478482962484409 2176 676033 SGTC_1108 betulinic acid 729.144 nM 0.053692507790013 0.489167623865813 no 1714 0.478590076055181 2299 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3151 9099821 49.47 µM 0.0512364961229996 0.488253900803766 no 1715 0.479568535161589 2261 17174189 SGTC_1421 4029-0249 71.4 µM 0.0510962010836475 0.488201707911188 no 1716 0.479624431568298 2320 2894095 SGTC_27 0485-0001 32.618 µM 0.0508784342502309 0.488120694178984 no 1717 0.479711195112039 2303 2054479 SGTC_2180 6301957 200 µM 0.0498606464136793 0.487742062764579 no 1718 0.480116718943264 2314 845462 SGTC_2325 6158266 200 µM 0.0492373777807416 0.48751020348477 no 1719 0.480365062107565 2264 3623240 SGTC_1204 4049-0315 18.3 µM 0.0485692417867499 0.487261657995906 no 1720 0.480631291261272 2286 588402 SGTC_2665 lovastatin 100 µM 0.048500381555207 0.487236042382827 no 1721 0.480658730182083 2296 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1970 st070122 35.8 µM 0.048196761257206 0.487123097994439 no 1722 0.480779715666122 2286 102928 SGTC_2875 9039966 71.43 µM 0.0481923329794596 0.487121450717193 no 1723 0.48078148024285 2277 6463691 SGTC_2874 9043904 71.43 µM 0.0480516402185249 0.487069114461478 no 1724 0.480837543582437 2199 4463428 SGTC_1373 2887-0003 58.5 µM 0.0467221938683171 0.486574585253085 no 1725 0.481367320755455 2271 776948 SGTC_1472 k841-0093 193 µM 0.046678674351636 0.486558397150636 no 1726 0.481384663608586 2312 X1472 SGTC_2443 5493264 126.67 µM 0.0461312563948279 0.486354774134059 no 1727 0.481602816759621 2306 5340055 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0458560500604468 0.486252406994868 no 1728 0.481712492135992 2284 115019 SGTC_3210 9128157 49.47 µM 0.0453547956065194 0.486065960186838 no 1729 0.481912255880988 2138 17590849 SGTC_592 k241-0073 46.5 µM 0.0450920647873303 0.485968235939859 no 1730 0.482016963186538 2330 4230158 SGTC_2139 5578692 56.4705 µM 0.0449138669945792 0.48590195471996 no 1731 0.482087981867929 2331 650991 YMR113W FOL3 SGTC_2958 9077254 16.72 µM 0.0448120829961751 0.485864096021743 no 1732 0.482128546965383 2271 16457351 SGTC_1630 st005209 31.3 µM 0.0446361084496484 0.485798642347849 no 1733 0.482198680474997 2331 3367314 SGTC_1984 st072354 53.1 µM 0.0439451329914279 0.485541637973801 no 1734 0.482474069552277 2254 5762938 SGTC_2277 7947813 106.88 µM 0.0430968175346952 0.485226120109739 no 1735 0.482812178091773 2290 1246798 SGTC_2880 9042983 58.44 µM 0.0416633480533499 0.484692984344498 no 1736 0.483383536296142 2287 6464714 SGTC_514 4466-0038 2.65 nM 0.0411284496190237 0.484494051954105 no 1737 0.483596747135265 2216 5722064 SGTC_163 TUB2.036 7.546 µM 0.040383239866081 0.48421690978889 no 1738 0.483893795999283 2340 15992207 YJR013W GPI14 SGTC_1277 0873-0036 22 µM 0.0398413730103441 0.484015395261064 no 1739 0.484109795754333 2318 5965735 SGTC_530 4358-1714 28 µM 0.0393932009135261 0.483848727901435 no 1740 0.48428845029435 2260 1564641 SGTC_3049 9092223 49.47 µM 0.0385243975519918 0.483525643199336 no 1741 0.484634789743043 2286 8623917 SGTC_891 0929-0073 133 µM 0.0378489375903283 0.48327446519264 no 1742 0.484904062873818 2314 5603632 SGTC_1934 st074720 32.6 µM 0.0358296759517393 0.482523618154843 no 1743 0.48570908513284 2342 17250992 SGTC_2013 4024628 200 µM 0.035484226972608 0.482395171722069 no 1744 0.485846811753752 2302 5230760 SGTC_3003 9075612 71.4286 µM 0.0334105187857199 0.481624154854437 no 1745 0.486673610784356 2307 6501993 SGTC_1935 st074532 41.6 µM 0.0326129795016837 0.481327643212288 no 1746 0.48699160959573 2319 2829742 SGTC_2318 6029776 164 µM 0.0315264223999526 0.480923696279188 no 1747 0.487424860293341 2334 818325 SGTC_682 0kpi-0099 17 µM 0.0276105307126936 0.479468059355797 no 1748 0.488986391287153 2319 1714895 YML126C ERG13 SGTC_2011 4012611 177 µM 0.0274735596484241 0.479417148556825 no 1749 0.489041014114447 2338 2049887 SGTC_508 roscovitine 141 µM 0.0223787229706401 0.477523693464622 no 1750 0.491072926355694 2366 160355 A CDKinase inhibitor. SGTC_1216 1165-0504 9.65 µM 0.0220697648875028 0.477408887560266 no 1751 0.491196152361971 2365 6304004 SGTC_2096 5468907 200 µM 0.0216079642618991 0.477237290309779 no 1752 0.491380340226854 2363 759785 SGTC_643 k048-0106 28.4 µM 0.0206583878071426 0.476884457161965 no 1753 0.491759081824354 2361 6763920 SGTC_1991 st073000 8.92 µM 0.0196086245255025 0.476494418798375 no 1754 0.492177791890238 2351 4301969 YIL048W NEO1 SGTC_2925 9010536 32.5 µM 0.0192252169246932 0.476351969731217 no 1755 0.492330720560834 2349 2994177 SGTC_1458 k015-0034 6.33 µM 0.0189416491964924 0.476246616542393 no 1756 0.49244382711929 2344 3598957 SGTC_319 1348-1596 45.5 µM 0.018600194570364 0.476119758987376 no 1757 0.492580023809434 2372 5380505 SGTC_3075 9116269 49.47 µM 0.0184348881353535 0.476058345048484 no 1758 0.49264596022976 2342 17015205 YNL244C SUI1 SGTC_2982 9019404 25.97 µM 0.0183234066550758 0.476016928247312 no 1759 0.492690427394717 2366 22333232 SGTC_2397 5161689 200 µM 0.0166349615259297 0.475389681142417 no 1760 0.493363916574186 2354 2259942 SGTC_3309 9129340 25.759 µM 0.0166072931436637 0.475379403010192 no 1761 0.493374953137105 2347 17158987 SGTC_1066 ketoconazole 628 nM 0.0161509791261275 0.47520989580026 no 1762 0.493556971673012 2366 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_942 3253-1115 227 µM 0.0158998720748703 0.475116618842802 no 1763 0.493657136029759 2364 46497897 SGTC_2420 aureobasidin a 50 nM 0.0158575534526045 0.47510089917813 no 1764 0.493674016589216 2364 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2470 5664817 21.68 µM 0.0149357572025156 0.474758498636476 no 1765 0.494041716488776 2382 2859561 SGTC_487 nimodipine 119 µM 0.0148712548192993 0.474734539968454 no 1766 0.494067446358976 2382 4497 L-type voltage-gated calcium channels inhibitor SGTC_177 1327-0068 8.361 µM 0.0145549061652828 0.474617037225666 no 1767 0.494193637552543 2384 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1097 itavastatin 7.23 µM 0.0136661829847699 0.47428694679481 no 1768 0.494548151498213 2378 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_20 0481-0013 4.944 µM 0.0122505552468541 0.473761189502825 no 1769 0.495112857794486 2380 182045 SGTC_3237 9133362 49.47 µM 0.0117477753958541 0.473574470449462 no 1770 0.49531342349343 2384 43845137 SGTC_1033 k072-0102 21.3 µM 0.0117078724985931 0.4735596518237 no 1771 0.495329341351533 2388 5965931 SGTC_742 0kpi-0133 140 µM 0.0113531035615015 0.473427903900995 no 1772 0.495470864271369 2378 2728852 SGTC_214 4373-3496 70 µM 0.0110096883184704 0.4733003750842 no 1773 0.495607858566846 2353 3779166 SGTC_2690 usnic acid 100 µM 0.0110071497511862 0.473299432385834 no 1774 0.495608871247305 2380 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_949 1165-0505 146 µM 0.0107229709407794 0.473193903373826 no 1775 0.495722235498093 2378 6244267 SGTC_3015 9080845 49.47 µM 0.0106210258478331 0.473156046804802 no 1776 0.49576290339 2379 5296973 SGTC_1125 tnp00248 1.32998 µM 0.0106030056667344 0.473149355166781 no 1777 0.495770091997357 2393 24207736 SGTC_1368 1852-0141 284 µM 0.0104973460055288 0.473110119520163 no 1778 0.495812241757695 2359 2838987 SGTC_1229 0139-0193 12.2 µM 0.00981527983417269 0.472856847439651 no 1779 0.496084332752658 2388 3090752 SGTC_308 4092-1169 104 µM 0.00837669717498662 0.472322693697122 no 1780 0.496658220408411 2391 2268590 YDL196W YDL196W SGTC_1512 0259-0544 12.2 µM 0.00819655475680972 0.472255809302218 no 1781 0.496730084367992 2376 18476 SGTC_2001 4023502 57.655 µM 0.0078247406440798 0.472117762327056 no 1782 0.496878411977953 2383 108941 YCR052W RSC6 SGTC_752 1896-0090 130 µM 0.00763893348024504 0.472048777181622 no 1783 0.49695253609585 2390 772567 SGTC_3055 9094636 49.47 µM 0.00660090514269439 0.471663400982518 no 1784 0.497366638973119 2390 25236176 SGTC_491 tetrandrine 80.3 µM 0.00627407955273336 0.471542069881554 no 1785 0.497497020817066 2385 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_294 k038-0071 157 µM 0.00511974541454747 0.471113554786838 no 1786 0.497957526012067 2385 24152826 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.00479280845528131 0.470992194404977 no 1787 0.4980879533856 2397 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2459 5811157 9.22 µM 0.00457980403068524 0.470913127710363 no 1788 0.498172928923225 2398 2870684 YBR192W RIM2 SGTC_3071 9117417 49.47 µM 0.00446774300106634 0.470871531404441 no 1789 0.498217634348462 2396 45595590 YGL055W OLE1 SGTC_1636 st007707 68.9 µM 0.00313297259379915 0.470376098104749 no 1790 0.498750126813687 2396 403051 SGTC_1825 st052143 62.6 µM 0.00284847107813666 0.470270504179472 no 1791 0.498863625989147 2398 674173 SGTC_588 3970-1144 52.9 µM 0.00244488799848885 0.470120716222456 no 1792 0.499024631778264 2392 1888707 SGTC_962 1254-0300 21.5 µM 0.00123971934355585 0.469673448804876 no 1793 0.49950542366471 2401 7340576 SGTC_3334 9142812 21.919 µM 0.00074111582202178 0.469488416061265 no 1794 0.499704337590987 2397 45283678 SGTC_24 0417-1663 219 µM -0.000405870277885035 0.469062792350906 no 1795 0.499838081190239 2407 4329390 SGTC_3245 9134821 49.47 µM -0.000486949758499306 0.469032706701748 no 1796 0.499805735160581 2408 17014901 SGTC_1475 4092-1048 11.7 µM -0.00212758193664837 0.468423965939779 no 1797 0.499151218250803 2414 2881759 SGTC_1516 st013856 110 µM -0.0024041976555834 0.468321337576079 no 1798 0.499040864828739 2422 5281404 A mutagen and neurotoxin. SGTC_686 1319-0111 510 µM -0.00271000811085852 0.46820788000074 no 1799 0.498918864507684 2412 4562600 SGTC_1919 st067113 52.3 µM -0.00342210641466823 0.467943697137027 no 1800 0.498634779727796 2418 1268243 SGTC_2647 atorvastatin 60.16 µM -0.0037601267485431 0.467818299188706 no 1801 0.498499929995142 2409 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_539 4859-0462 2.54 µM -0.00402880008359654 0.467718629695918 no 1802 0.498392745655322 2410 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2147 5545932 89.7195 µM -0.00483879907397952 0.467418157409805 no 1803 0.498069605996058 2418 797404 SGTC_1150 3909-7983 10.9 µM -0.00484998668682214 0.467414007450748 no 1804 0.49806514283665 2422 23965914 SGTC_586 0957-0265 8.15 µM -0.00655515474496807 0.466781530130917 no 1805 0.497384890346239 2413 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1860 st056228 74.6 µM -0.00821636839192203 0.466165436929359 no 1806 0.496722180137381 2453 688679 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0094665595530351 0.465701832748168 no 1807 0.4962234455509 2424 2374 Ca(2+)-ATPase inhibitor. SGTC_204 PMA1.184 62.41 µM -0.00984310196260127 0.465562209884972 no 1808 0.496073233865459 2421 2252213 YGL008C PMA1 SGTC_1670 st016595 4.04 µM -0.0109579095319977 0.465148861381654 no 1809 0.495628514067979 2427 597879 SGTC_2726 cimetidine 79.27 µM -0.0111616542057919 0.465073320954575 no 1810 0.495547236674364 2426 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3347 9188721 44.724 µM -0.0112960235473939 0.465023502831907 no 1811 0.495493634442224 2443 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3014 9081533 49.47 µM -0.0116920870954828 0.464876663432212 no 1812 0.495335638385233 2432 21367265 SGTC_2427 5545055 42.75 µM -0.0120560396606924 0.464741733301843 no 1813 0.495190452555193 2430 5372858 SGTC_3324 9138759 60.749 µM -0.0126921936961927 0.464505898173392 no 1814 0.494936683247028 2481 45595710 SGTC_2228 7354201 200 µM -0.0128753746141295 0.464437991621946 no 1815 0.4948636106052 2435 753451 SGTC_2311 7694451 200 µM -0.0129209818917111 0.464421084820252 no 1816 0.494845417447277 2439 2163142 SGTC_2135 5326629 150.42 µM -0.0136868517605954 0.464137183392641 no 1817 0.494539906620779 2436 5020077 SGTC_2461 5755302 26.15 µM -0.0165111657050166 0.463090393239312 no 1818 0.49341329717919 2429 2788904 SGTC_2442 5158906 48.48 µM -0.0166514553169692 0.46303840357317 no 1819 0.493357337414841 2451 1893835 SGTC_550 4123-0385 25.7 µM -0.0175620661336852 0.462700957393471 no 1820 0.492994109423247 2464 5731123 SGTC_1529 apigenin 74 µM -0.0187365673167226 0.462265760702722 no 1821 0.492525628434509 2444 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3330 9141424 71.43 µM -0.0208048383347861 0.461499498928487 no 1822 0.491700669071185 2444 27261020 SGTC_813 k007-0158 173 µM -0.020827212915237 0.461491210275707 no 1823 0.491691744838712 2469 6523916 SGTC_904 1141-0088 396 µM -0.0209040229522251 0.461462756161011 no 1824 0.491661108737213 2451 1378119 SGTC_2128 5255449 168.493 µM -0.0209580313252274 0.461442748992312 no 1825 0.491639567232998 2459 736008 SGTC_1398 3558-0053 112 µM -0.0220634597842957 0.461033269300418 no 1826 0.491198667121885 2451 4532369 SGTC_2239 6685329 187.64 µM -0.0228707275676315 0.46073426221763 no 1827 0.490876695151446 2538 805680 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0229510152839195 0.460704525346226 no 1828 0.490844673392173 2436 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2287 7945887 168.79 µM -0.0233985624358298 0.46053876738145 no 1829 0.49066617585164 2450 1245853 SGTC_159 3970-0959 50 µM -0.0242391298911115 0.460227465107287 no 1830 0.490330933075443 2478 6615653 SGTC_2737 bleomycin 30.5 nM -0.0243489372436119 0.460186799996451 no 1831 0.490287139205333 2448 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_318 1488-0629 67.2 µM -0.0245674801545167 0.460105867933343 no 1832 0.490199979271873 2496 3662576 SGTC_751 0833-0568 350 µM -0.0245901854245585 0.460097459682352 no 1833 0.490190923915335 2478 6954252 SGTC_863 0466-0191 129 µM -0.0248822188904605 0.45998931498614 no 1834 0.490074455056825 2453 765160 YPR165W RHO1 SGTC_2717 st081029 62.2815 µM -0.0251594197210907 0.459886665791762 no 1835 0.489963902536322 2451 5292846 SGTC_99 0109-0120 622.8 µM -0.02571052354385 0.45968259656142 no 1836 0.489744115029233 2455 759414 SGTC_1323 1348-1351 11.2 µM -0.0268164551304952 0.459273111253012 no 1837 0.489303064320758 2462 6989654 SGTC_2718 lomofungin 53.02 µM -0.0270340445144022 0.459192551074612 no 1838 0.489216290175909 2455 5351222 A RNA synthesis inhibitor. SGTC_2252 omeprazole 400 µM -0.0272528091818362 0.459111557449144 no 1839 0.489129047845281 2515 4594 A proton pump inhibitor. SGTC_1325 1431-0015 227 µM -0.0283729587461894 0.458696869181604 no 1840 0.488682345655144 2458 1103340 SGTC_2107 5363541 170.161 µM -0.0289711975734946 0.458475414798057 no 1841 0.488443780977454 2453 244052 SGTC_2945 9067681 61.76 µM -0.0298375036934643 0.458154750872432 no 1842 0.4880983242252 2443 16456930 SGTC_676 falcarinol 140 µM -0.0300313468607971 0.458083003385118 no 1843 0.488021026629886 2453 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_350 k064-0020 19.8 µM -0.0309302424228701 0.457750311594716 no 1844 0.487662585745174 2469 2790705 SGTC_1105 epirubicin 18.1 µM -0.0332749660085635 0.456882641788201 no 1845 0.486727658466552 2458 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_826 1683-5028 118 µM -0.0345042823455246 0.456427812597122 no 1846 0.486237513782637 2499 722377 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0360068609766212 0.4558719579104 no 1847 0.485638444117518 2545 6710655 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0387952464235557 0.454840669410716 no 1848 0.484526817393819 2488 6857784 SGTC_2791 5663188 71.43 µM -0.0388103589190552 0.454835080854644 no 1849 0.484520792917508 2513 54690634 SGTC_2052 5265182 7.135 µM -0.0392635236496338 0.454667506037483 no 1850 0.484340144044344 2491 1239884 SGTC_1870 st057514 26.5 µM -0.0400478376169655 0.454377495333351 no 1851 0.484027493978873 2473 5393161 SGTC_1573 oleylamine 1.06 µM -0.0415690129593201 0.45381508962435 no 1852 0.483421137978261 2475 5356789 An amine of the fatty acid oleic acid. SGTC_1300 1094-0077 113 µM -0.0418219427448223 0.453721585910766 no 1853 0.483320321266795 2482 5532636 SGTC_2625 euphol 100 µM -0.041898203436867 0.45369339417111 no 1854 0.483289924295868 2501 6708538 A triterpene alcohol. SGTC_3109 9122853 49.47 µM -0.0430748849474699 0.45325843304124 no 1855 0.482820919810347 2541 1234709 SGTC_11 0438-0307 1.3 µM -0.0434332875025487 0.453125960406142 no 1856 0.482678071569535 2505 4011476 SGTC_2191 5911152 200 µM -0.043792211365105 0.452993300313232 no 1857 0.482535017780095 2488 2875902 SGTC_663 1486-0733 13.9 µM -0.0441823255040205 0.452849118085135 no 1858 0.482379535249671 2495 722445 YPR165W RHO1 SGTC_931 2812-0076 566 µM -0.0442137050739358 0.452837520784307 no 1859 0.482367028833879 2468 3450959 SGTC_450 aminopyrene 156 nM -0.0458685350136241 0.45222598390049 no 1860 0.481707516595704 2472 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1939 st074455 53.6 µM -0.046061643909116 0.452154628508274 no 1861 0.481630558633632 2488 1644229 SGTC_2655 perillic acid 100 µM -0.0461267884270062 0.452130557398988 no 1862 0.481604597325463 2486 5702197 An apoptosis inducer. SGTC_103 0844-0104 51.839 µM -0.0471636982443798 0.451747439629169 no 1863 0.481191379956232 2575 5375804 SGTC_981 1488-1094 54.9 µM -0.0472646566858445 0.451710139866807 no 1864 0.481151148232233 2493 3449522 SGTC_593 1203-0218 61.7 µM -0.0479450059439295 0.451458791476331 no 1865 0.48088003552759 2505 3666956 SGTC_2291 7917025 104.35 µM -0.0512550602838109 0.450236203687694 no 1866 0.479561138851155 2508 2964612 SGTC_2817 7995342 71.43 µM -0.0519500814936253 0.449979553153077 no 1867 0.479284234429941 2501 18879975 SGTC_1626 st003712 1.76 µM -0.0525688056745644 0.44975109442563 no 1868 0.479037736027768 2562 24207035 SGTC_625 k213-0058 121 µM -0.0538657817155338 0.449272251005402 no 1869 0.478521049651453 2553 3655420 SGTC_877 0771-0151 33.1 µM -0.0542771731802714 0.449120380717354 no 1870 0.478357167951209 2592 6166523 SGTC_1030 k029-0042 36.7 µM -0.0554633509775039 0.448682530202915 no 1871 0.477884663334742 2559 6080581 SGTC_3214 9129694 49.47 µM -0.0555315087754114 0.448657373197996 no 1872 0.477857514148899 2512 17158655 SGTC_1469 k284-2957 126 µM -0.0557739145879602 0.448567903022178 no 1873 0.477760957865569 2548 23884841 SGTC_3193 9111931 49.47 µM -0.0563727183443181 0.44834690024693 no 1874 0.47752244499604 2525 17087244 SGTC_2348 9022543 33.42 µM -0.0569877786737691 0.448119914285348 no 1875 0.477277465262847 2560 3162678 YDL140C RPO21 SGTC_2650 prasterone 100 µM -0.0573621407517039 0.447981765520656 no 1876 0.477128360312183 2498 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_21 0849-0113 22.993 µM -0.0573757714491368 0.447976735578797 no 1877 0.477122931391844 2498 1560156 SGTC_2288 7946289 167.31 µM -0.0584278533715917 0.447588526093263 no 1878 0.476703914441154 2530 1246052 SGTC_283 0987-0079 11.7 µM -0.0591044054352947 0.447338910502018 no 1879 0.4764344748742 2501 411556 SGTC_2831 7999036 19.48 µM -0.0594526917618378 0.447210417508967 no 1880 0.476295772643861 2624 2988270 SGTC_2007 4011539 71.82 µM -0.0598316528076747 0.447070614011148 no 1881 0.476144857716235 2520 45595301 SGTC_2102 5377816 72.7585 µM -0.0598618693223289 0.447059467041597 no 1882 0.476132824639324 2562 1379702 SGTC_2814 7977482 42.97 µM -0.0606753047685555 0.446759403831725 no 1883 0.475808899687623 2563 6456762 SGTC_2088 5278280 127.392 µM -0.0607910275078489 0.446716718053059 no 1884 0.475762818059003 2554 791502 SGTC_315 k915-0449 187 µM -0.0610726687684628 0.44661283373471 no 1885 0.475650667835477 2542 20970215 YNL149C PGA2 SGTC_401 neomycin 50 µM -0.0621426732473857 0.446218192473371 no 1886 0.475224607154359 2546 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_745 0469-0705 296 µM -0.0623158051677872 0.446154342597524 no 1887 0.475155671117265 2542 3486736 SGTC_376 3970-0862 59.1 µM -0.0634290763575477 0.445743809171289 no 1888 0.474712417138341 2564 3135186 SGTC_383 2324-0395 7.37 µM -0.066601528689104 0.444574246059685 no 1889 0.473449464366022 2608 3146421 SGTC_1877 wortmannin 25 µM -0.066939950627451 0.444449510995444 no 1890 0.47331475417315 2534 312145 A covalent inhibitor of PI 3-kinase. SGTC_1820 st053765 18.6 µM -0.0679534014724976 0.444076007715474 no 1891 0.472911364364464 2578 3690829 SGTC_601 0986-0029 62.9 µM -0.0692737813834687 0.44358946149988 no 1892 0.472385847507611 2540 24747981 SGTC_1122 capsaicin 818.572 nM -0.0698860135796163 0.443363889133651 no 1893 0.472142192727901 2644 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0702086977269772 0.443245005957663 no 1894 0.472013775812905 2498 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2393 9031399 185.94 µM -0.070894244836102 0.442992453910363 no 1895 0.471740961903784 2592 1526623 YDL150W RPC53 SGTC_2327 6189656 200 µM -0.072349459591096 0.442456437122499 no 1896 0.471161902366073 2594 5349088 SGTC_209 4077-0173 175.592 µM -0.0729970340281047 0.442217942030556 no 1897 0.470904238859232 2606 15993494 SGTC_909 3448-9333 149 µM -0.0735377042346801 0.442018834719166 no 1898 0.470689120820619 2535 3344074 SGTC_1738 st035555 74 µM -0.0741567078240508 0.441790898329101 no 1899 0.470442846554619 2606 5331140 SGTC_2807 7945238 51.95 µM -0.0761095917143869 0.441071912363125 no 1900 0.469665954596356 2603 17148797 SGTC_2803 7707263 71.43 µM -0.0764073729719011 0.440962296353432 no 1901 0.469547501986135 2567 2199229 SGTC_2661 dactinomycin 12.96 µM -0.0764666778413688 0.440940466227346 no 1902 0.46952391178132 2548 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1172 0370-0043 85 µM -0.0769648704780483 0.440757088579569 no 1903 0.46932574567013 2642 376585 SGTC_2824 7998404 51.95 µM -0.0791090080129754 0.439968007417685 no 1904 0.468472959306345 2540 837851 SGTC_1014 4130-3005 69.3 µM -0.0800310210516735 0.439628763157441 no 1905 0.46810629193088 2561 743608 SGTC_1625 st003711 30.1 µM -0.0833520072230886 0.438407213012562 no 1906 0.46678582417151 2626 24207034 YER133W GLC7 SGTC_2938 9059746 27.26 µM -0.0836709218599927 0.438289938113382 no 1907 0.46665903852328 2628 6471769 SGTC_1230 0170-0365 3.77 µM -0.0849469095242603 0.437820771805135 no 1908 0.466151799063594 2627 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_37 0566-0070 1.56 µM -0.085557937733536 0.437596134512934 no 1909 0.465908918311537 2634 1626686 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0864008832627234 0.437286268587676 no 1910 0.465573872407849 2596 1273210 SGTC_2212 7123476 200 µM -0.0867605737301967 0.437154058432182 no 1911 0.465430913504585 2583 1085715 SGTC_2506 ethyl hematommate 54.16 µM -0.087568424551194 0.436857145160655 no 1912 0.465109849649498 2630 3940691 An allergen. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0875707694303857 0.436856283387689 no 1913 0.465108917757979 2601 279621 SGTC_1945 st075991 56.6 µM -0.0885073045976214 0.43651211878858 no 1914 0.464736739447951 2601 1084980 SGTC_1380 2291-0730 164 µM -0.0888116770899909 0.436400276156223 no 1915 0.46461578869462 2632 2999191 SGTC_1040 k898-0338 155 µM -0.0895929243120545 0.436113227695459 no 1916 0.464305353687808 2562 20969351 SGTC_2481 5478948 45.16 µM -0.089928807713396 0.435989826629285 no 1917 0.464171894324671 2666 77792 SGTC_1875 nocodazole 6 µM -0.0917684942264455 0.435314050312209 no 1918 0.463440988185445 2548 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2780 5215298 71.43 µM -0.093025612793304 0.434852378536724 no 1919 0.462941606690208 2604 2834131 SGTC_219 mitoxanthrone 164.414 µM -0.0936499301829039 0.434623133432598 no 1920 0.462693622658172 2641 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2508 celastrol 40.54 µM -0.0944888454588579 0.434315124065637 no 1921 0.462360421418077 2552 122724 Celastrol is a natural product and antioxidant. SGTC_3135 9127742 49.47 µM -0.0963365864344216 0.433636863261735 no 1922 0.46162662721627 2667 3643468 SGTC_2178 5812956 200 µM -0.098576802571788 0.432814796575365 no 1923 0.460737144580024 2547 5403383 SGTC_2557 derrustone 83.84 µM -0.0987607445626227 0.432747310336737 no 1924 0.460664118682221 2693 629853 An antioxidant. SGTC_1906 st060206 94.7 µM -0.098938154985547 0.432682222314928 no 1925 0.460593687106556 2582 5133468 SGTC_599 1935-0052 86.5 µM -0.0990878175176606 0.43262731581042 no 1926 0.460534272348135 2589 9557311 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.100449784801494 0.432127712503395 no 1927 0.459993623521463 2584 23665772 A membrane-active detergent. SGTC_823 0417-1665 178 µM -0.100686047284614 0.432041056600162 no 1928 0.459899843868303 2664 3429856 SGTC_897 1000-0139 31.4 µM -0.100895895909372 0.4319640914631 no 1929 0.459816550536857 2571 6151020 SGTC_1555 citronellol 128 µM -0.100927139054921 0.431952632790673 no 1930 0.459804149626208 2583 8842 A terpine precursor. SGTC_2115 tiliquinol 12.7705 µM -0.104012895743022 0.430821190514474 no 1931 0.458579557379156 2692 71208 A bioactive hydroxyquinoline. SGTC_1217 1183-1422 255 µM -0.104266261106174 0.430728315121602 no 1932 0.458479025839231 2695 2849664 SGTC_1161 k007-0610 110 µM -0.104914644610627 0.430490656554447 no 1933 0.458221769191164 2628 5843850 SGTC_3129 9127257 49.47 µM -0.105089430091249 0.430426594967834 no 1934 0.458152423213221 2620 837894 SGTC_3093 9117344 49.47 µM -0.10615511357097 0.430036045138518 no 1935 0.457729641912765 2744 24824913 SGTC_2492 derrusnin 100 µM -0.106192431356301 0.430022370219541 no 1936 0.457714837947573 2576 1715307 Part of coumarin class of compounds. SGTC_48 0382-0018 55 µM -0.1068479815417 0.429782160780464 no 1937 0.457454790778867 2692 762596 SGTC_261 5-fluorouridine 15.376 µM -0.107205240772608 0.429651263295997 no 1938 0.457313078929083 2638 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1712 st032288 53.4 µM -0.107535138375612 0.429530397803281 no 1939 0.457182225269561 2601 2883011 SGTC_1378 2093-0007 380 nM -0.107637222738957 0.429492998211829 no 1940 0.457141734516187 2674 3618014 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.108561505384262 0.429154407189704 no 1941 0.456775147245048 2671 5379071 SGTC_971 1315-0384 26.7 µM -0.108591245744793 0.429143513313934 no 1942 0.456763352287475 2629 6769120 SGTC_3044 9093193 49.47 µM -0.109418963934636 0.428840342332396 no 1943 0.456435096505305 2697 25236277 SGTC_2976 9009005 19.48 µM -0.112351811146542 0.427766458118049 no 1944 0.455272231230412 2643 2993148 SGTC_373 0844-0104 25.9 µM -0.113100812312608 0.42749229109362 no 1945 0.454975315496785 2667 5375804 SGTC_2940 9060638 45.86 µM -0.114853910240607 0.426850718054292 no 1946 0.454280458775829 2691 4027022 SGTC_968 1309-0633 340 µM -0.11492490198889 0.426824741601143 no 1947 0.454252323467051 2616 3761976 SGTC_1791 st048313 56.1 µM -0.115063835967742 0.426773905456343 no 1948 0.454197262092635 2625 1204976 SGTC_2374 9071832 200 µM -0.117374402359566 0.425928644800886 no 1949 0.453281683899978 2603 17381698 SGTC_717 1532-0246 73.2 µM -0.118597130984508 0.425481478723946 no 1950 0.452797269226673 2673 9561992 SGTC_482 fipronil 114 µM -0.120560772047178 0.42476355311642 no 1951 0.452019470752884 2607 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3353 9151644 39.2805 µM -0.120775174459089 0.424685180646856 no 1952 0.451934557025955 2716 4909158 SGTC_3154 9100113 49.47 µM -0.120830737992062 0.424664870487389 no 1953 0.45191255153758 2636 25237525 SGTC_2768 sulfasalazine 50.2 µM -0.121329164594048 0.424482689371209 no 1954 0.451715160323043 2649 5384001 An antioxidant and salicylic acid derivative. SGTC_446 go6976 132 µM -0.123085346398687 0.423840911912059 no 1955 0.451019757460622 2687 3501 A protein kinase C inhibitor. SGTC_3012 9080433 71.4286 µM -0.123618669885593 0.423646054566155 no 1956 0.45080860472154 2624 17688859 SGTC_413 propylparaben 100 µM -0.123715600584634 0.423610641555732 no 1957 0.45077022953885 2620 7175 A pharmaceutical preservative. SGTC_1218 1348-1416 30.7 µM -0.123953929444737 0.423523572256333 no 1958 0.450675876316442 2613 6787668 SGTC_935 2996-0153 430 µM -0.125136082970113 0.423091748326049 no 1959 0.450207908860075 2637 23738523 SGTC_591 4299-0174 154 µM -0.125288605697252 0.423036040652706 no 1960 0.450147536220472 2667 5509088 SGTC_1438 4092-1045 4 µM -0.125368768755661 0.423006762370902 no 1961 0.450115805966268 2631 1351342 SGTC_3174 9107204 49.47 µM -0.125694600615868 0.42288776184603 no 1962 0.449986838026752 2720 3938802 SGTC_1008 4106-0037 6 µM -0.125953019942056 0.422793386773354 no 1963 0.449884556486518 2602 2905394 SGTC_2240 6690706 185.951 µM -0.126044985914361 0.422759801749909 no 1964 0.449848157452568 2607 805876 SGTC_790 1575-0012 79.1 µM -0.127749063062408 0.422137592204293 no 1965 0.449173780722549 2630 378741 YLR208W SEC13 SGTC_2271 7849410 118.62 µM -0.128958777419882 0.421696007121825 no 1966 0.448695133621469 2600 972430 SGTC_74 000s-0487 160.283 µM -0.129965001600526 0.421328777545889 no 1967 0.448297058233516 2617 677548 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.130162634867629 0.42125665773104 no 1968 0.448218878043276 2754 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2394 5221648 200 µM -0.130313784387669 0.421201502426321 no 1969 0.448159087350117 2744 788586 SGTC_1234 0326-0494 15.5 µM -0.130348137073996 0.421188967154684 no 1970 0.448145498513655 2746 1547813 SGTC_476 mead acid 10 µM -0.133163120334046 0.420162054312541 no 1971 0.447032188375195 2643 5312531 An omega 9 fatty acid. SGTC_2176 5809774 33.9695 µM -0.133169938359255 0.420159567736812 no 1972 0.447029492387373 2762 2870539 SGTC_1404 3909-7820 48.3 µM -0.134212842373122 0.419779251811208 no 1973 0.446617135522945 2661 23741373 SGTC_2003 4023581 200 µM -0.134377142608097 0.419719343247098 no 1974 0.446552177624203 2746 16641307 SGTC_639 0833-0042 114 µM -0.134498617051751 0.419675051387389 no 1975 0.446504152293495 2670 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_141 0443-0274 32.331 µM -0.135572420629404 0.419283566785996 no 1976 0.446079654633352 2705 1627241 SGTC_3123 9126162 49.47 µM -0.136302275832742 0.419017523596861 no 1977 0.44579116241103 2657 25239884 SGTC_2524 avocatin b 10.57 µM -0.137496336243468 0.418582350526578 no 1978 0.445319244248338 2750 6710748 SGTC_2692 st077426 47.7 µM -0.137533570361525 0.418568782221254 no 1979 0.445304529772229 2726 25238571 SGTC_1166 k206-0078 225 µM -0.137965047289966 0.418411556865814 no 1980 0.445134020775177 2641 5404595 SGTC_1313 1220-0047 237 µM -0.1389343728561 0.418058393066219 no 1981 0.444751004376631 2700 3528706 SGTC_1522 st012842 45.6 µM -0.139320904388395 0.417917582686052 no 1982 0.444598285830478 2628 3491067 YOR116C RPO31 SGTC_1855 st056195 39.6 µM -0.139340388432242 0.417910485081386 no 1983 0.444590587905427 2792 4028379 SGTC_1753 st043925 64 µM -0.139366535124019 0.417900960463991 no 1984 0.444580257676481 2692 670181 SGTC_2356 9061756 188.97 µM -0.142042292662229 0.416926501277725 no 1985 0.443523299814468 2703 20104043 SGTC_2649 anisomycin 9.56 µM -0.143357107612811 0.416447857638165 no 1986 0.443004078089984 2706 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_515 4092-1064 102 µM -0.143638610085402 0.416345395894092 no 1987 0.442892925173751 2797 717353 SGTC_104 0074-0074 590.992 µM -0.143663115551946 0.416336476621967 no 1988 0.442883249257877 2635 3943124 SGTC_2306 7482397 179.52 µM -0.144065599787366 0.416189990315684 no 1989 0.442724334346101 2781 891448 SGTC_1202 1988-0068 29.6 µM -0.145508539383478 0.41566492049198 no 1990 0.442154687026344 2677 2850480 SGTC_2068 5226020 147 µM -0.147513471970777 0.414935597694669 no 1991 0.441363373479351 2694 1810509 SGTC_3218 9131285 49.47 µM -0.149431359235159 0.414238213087666 no 1992 0.440606634213067 2737 17156417 SGTC_1827 berberine 7.24 µM -0.150248085175291 0.413941316097669 no 1993 0.440284444977686 2675 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2094 5332512 191.667 µM -0.152401637685512 0.413158690880377 no 1994 0.439435082740221 2805 755774 SGTC_890 0929-0006 47.2 µM -0.154159046233088 0.412520284304233 no 1995 0.438742166243673 2681 1378169 SGTC_1725 st036284 20.55 µM -0.155310346240632 0.412102181605857 no 1996 0.438288329733238 2923 707914 SGTC_3142 9086498 49.47 µM -0.155476830907764 0.412041729771589 no 1997 0.43822270903961 2791 25236367 SGTC_3343 9148379 18.9835 µM -0.156224304488008 0.411770342236669 no 1998 0.437928109864249 2814 1955036 SGTC_988 1497-1057 103 µM -0.157186726161845 0.411420974997946 no 1999 0.437548844623147 2683 3533044 SGTC_1470 k295-0292 231 µM -0.15758626562918 0.411275959391619 no 2000 0.437391413388436 2786 5045612 SGTC_1286 0929-0070 131 µM -0.158219330712428 0.411046208879119 no 2001 0.437141985951823 2799 1420408 SGTC_2370 9071495 200 µM -0.158450495502919 0.410962322689345 no 2002 0.437050913321171 2737 21791103 SGTC_122 0236-0016 402.397 µM -0.158654897213289 0.410888151806371 no 2003 0.436970387393745 2706 6808838 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.159075269153464 0.41073562220913 no 2004 0.436804786226 2712 140250 A respiratory chain inhibitor. SGTC_493 zm226600 134 µM -0.159150805535059 0.410708215687315 no 2005 0.436775030624415 2850 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1321 1326-2144 215 µM -0.159719879863609 0.41050175505952 no 2006 0.436550870038786 2810 3513030 SGTC_2161 5662504 8.5105 µM -0.161192626394385 0.409967556693592 no 2007 0.435970844230873 2718 2859334 SGTC_1960 st011366 51.8 µM -0.161643690750953 0.409803978854996 no 2008 0.435793224739298 2675 3972846 SGTC_304 1310-0298 97 µM -0.163917183397612 0.408979739534027 no 2009 0.434898169836163 2692 1550234 SGTC_3042 9091578 49.47 µM -0.163992015077295 0.40895261663602 no 2010 0.434868714878673 2670 25236497 SGTC_1603 st002045 67.8 µM -0.165608656185785 0.40836676835715 no 2011 0.434232467357729 2722 5887985 SGTC_132 0417-1715 25.805 µM -0.166682860462624 0.407977604787894 no 2012 0.433809796115211 2751 6769098 SGTC_1395 3486-0190 4.35 µM -0.167859374373596 0.407551480558397 no 2013 0.433346955556334 2769 6748079 SGTC_222 nsc-310342 10.666 µM -0.16787968674534 0.407544124533566 no 2014 0.433338965470335 2698 432556 SGTC_633 0437-0093 97.7 µM -0.168152961968343 0.407445162435571 no 2015 0.433231472424952 2685 2831118 SGTC_603 3794-0023 45.9 µM -0.168207820242359 0.407425297131491 no 2016 0.43320989447046 2746 3802260 SGTC_1444 4112-3581 28 µM -0.168441684373726 0.407340612813308 no 2017 0.433117908583286 2701 2877249 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.168797501483557 0.407211776526118 no 2018 0.432977961826651 2883 688798 SGTC_756 0508-1999 28.3 µM -0.17177344862831 0.40613462297888 no 2019 0.431807820079022 2721 6753853 SGTC_155 k072-0202 43.6 µM -0.173003963035936 0.405689441410845 no 2020 0.4313241562723 2670 5857737 SGTC_2759 disulfiram 3.38 µM -0.173024753989996 0.405681920603061 no 2021 0.43131598509929 2714 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_152 4469-0003 551.229 µM -0.175114358023077 0.404926216535414 no 2022 0.430494888260808 2721 697280 SGTC_2502 avocadyne acetate 18.59 µM -0.176478178967758 0.404433182458656 no 2023 0.429959145144677 2670 3952079 SGTC_2534 helenine 20.12 µM -0.176516288745577 0.404419407591617 no 2024 0.429944176514124 2716 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_389 tpck 16.7 µM -0.17685963683027 0.404295308979226 no 2025 0.429809321949224 2780 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1144 3486-0183 12.5 µM -0.176993695807506 0.404246857752675 no 2026 0.429756670710007 2740 6744069 SGTC_2 0422-0095 29 µM -0.178306628457763 0.403772418984606 no 2027 0.429241086737412 2676 6790840 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.178669729590558 0.403641234427142 no 2028 0.429098519483642 3072 5282309 SGTC_2058 5236698 133 µM -0.178888638819633 0.403562150099537 no 2029 0.429012571898849 2754 766665 SGTC_1096 rimcazole 32.2 µM -0.179698827065308 0.403269491454108 no 2030 0.428694507160516 2702 18528119 A dopamine reuptake inhibitor. SGTC_1784 st039334 36.3 µM -0.181239090453807 0.402713262364982 no 2031 0.428089956446372 2972 3496984 SGTC_229 benomyl 22.8748 µM -0.181316100597101 0.402685457161502 no 2032 0.428059734516138 2795 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1291 0993-0025 5.79 µM -0.181793635658926 0.402513049835823 no 2033 0.427872339653103 2845 4353356 SGTC_140 0062-0056 502.533 µM -0.18286751368157 0.402125410566193 no 2034 0.427450986680655 2691 3758964 SGTC_2664 lyso-paf C-16 73.48 µM -0.184986167974668 0.401360919515992 no 2035 0.42661994234682 2738 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_761 k216-0224 480 µM -0.185647040807538 0.401122528554313 no 2036 0.426360780757885 2795 1340404 SGTC_558 k064-0027 21.3 µM -0.188709725063909 0.400018234733792 no 2037 0.425160164521215 2859 5088526 SGTC_699 0375-0592 111 µM -0.189897512403195 0.399590175872111 no 2038 0.424694720908502 2780 762578 SGTC_1349 flufenamic acid 69 µM -0.190817585148811 0.399258679816387 no 2039 0.424334255436934 2733 3371 A non-steroidal anti-inflammatory. SGTC_818 4072-2707 53.5 µM -0.191576264870904 0.398985387211727 no 2040 0.424037068004189 2725 882871 SGTC_666 0272-0154 136 µM -0.192674345318442 0.398589922953146 no 2041 0.423607008217126 2789 6870312 SGTC_610 4215-0184 155 µM -0.192824498867274 0.398535854522129 no 2042 0.423548208107139 2817 5605015 SGTC_288 1315-0019 35.1 µM -0.193434037116306 0.398316387367092 no 2043 0.423309530504934 2793 6811474 SGTC_1663 st014140 55.4 µM -0.193521068200445 0.398285054032163 no 2044 0.42327545393571 2756 4207120 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.193832505027278 0.398172934473823 no 2045 0.423153517166084 2744 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1180 1193-0155 285 µM -0.19400542533433 0.398110685515061 no 2046 0.423085816906207 2888 2921347 SGTC_3024 9090631 49.47 µM -0.194110880323992 0.398072724425879 no 2047 0.42304453119739 2774 25236383 SGTC_2873 9040596 71.43 µM -0.196101954650417 0.397356170240467 no 2048 0.422265183187486 2853 6463863 SGTC_713 1488-1073 324 µM -0.19643060134433 0.39723792904941 no 2049 0.422136573192333 2744 3312542 SGTC_2855 9016525 58.44 µM -0.197047197514167 0.397016114285057 no 2050 0.42189530173997 2729 43811474 SGTC_1691 st019933 84.6 µM -0.197096394675435 0.39699841749571 no 2051 0.421876052362051 2734 6176082 SGTC_824 1304-0008 100 µM -0.197241367763445 0.396946270228479 no 2052 0.42181932981384 2773 768245 SGTC_3162 9099653 49.47 µM -0.197602031863498 0.396816546234456 no 2053 0.421678222477386 2777 25237511 SGTC_777 1315-0167 517 µM -0.198886449501583 0.39635465855058 no 2054 0.421175784750356 2851 4221767 SGTC_34 0469-0683 81.75 µM -0.199223073100832 0.396233629820789 no 2055 0.421044125723164 2842 3690923 SGTC_2867 9039098 71.43 µM -0.201540554563621 0.395400680856023 no 2056 0.420137960989315 2734 6463460 SGTC_2730 imipramine 71.33 µM -0.201781077718773 0.395314259340125 no 2057 0.420043937533017 2767 3696 A tricyclic antidepressant. SGTC_552 k242-0005 476 µM -0.202068758214972 0.395210900650192 no 2058 0.419931485686017 2875 4088318 SGTC_3100 9120536 49.47 µM -0.203216483170523 0.394798616115144 no 2059 0.41948291496131 2710 16421196 SGTC_1009 4106-0057 9.87 µM -0.203504018288666 0.394695346488537 no 2060 0.419370552627759 2765 2928005 SGTC_3112 9123419 49.47 µM -0.203971305167719 0.394527533934776 no 2061 0.419187961329608 2747 17015854 SGTC_1065 prochlorperazine maleate 2.48 µM -0.204813192036698 0.3942252440535 no 2062 0.41885903987312 2778 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_76 0433-0009 400.328 µM -0.205057401547753 0.394137569522616 no 2063 0.418763638904161 2906 2841569 SGTC_1664 st014217 9.02 µM -0.206505076319705 0.39361794491211 no 2064 0.418198199934616 2791 3982782 SGTC_3168 9103419 49.47 µM -0.206830040804222 0.393501329002292 no 2065 0.418071297111576 2767 16649256 SGTC_1037 k284-1091 78.7 µM -0.207122149269469 0.393396511870417 no 2066 0.417957232266737 2761 3334711 SGTC_22 0964-0034 14.468 µM -0.207327953594977 0.39332266784769 no 2067 0.41787687229443 2803 138402 SGTC_1449 4112-4002 201 µM -0.209490171390116 0.392547081502923 no 2068 0.417032803633817 2803 2059539 SGTC_2705 st078069 42.8 µM -0.210063677317167 0.392341436684836 no 2069 0.416808987127911 2854 1530061 SGTC_1261 0712-0010 12.7 µM -0.212504139856377 0.391466684905314 no 2070 0.415856874199277 2918 2840123 SGTC_2887 9044784 58.44 µM -0.213809416865034 0.390999050360188 no 2071 0.415347840583399 2787 6465546 SGTC_1259 0671-0132 43 µM -0.215158688914966 0.390515819561796 no 2072 0.41482179903778 2818 X1259 SGTC_2708 st078559 56 µM -0.219207826977922 0.38906667147896 no 2073 0.41324407935375 2838 17250902 SGTC_1764 st044502 93.5 µM -0.220222282794399 0.388703848114299 no 2074 0.412849021713234 2928 8407 SGTC_2644 guaiazulene 100 µM -0.221800377343819 0.388139630598541 no 2075 0.412234642848773 2900 3515 A coloring agent. SGTC_1828 st055811 49 µM -0.22396238978487 0.387367027781211 no 2076 0.411393284238256 2949 5877589 SGTC_2648 atorvastatin 78.68 µM -0.224474679028374 0.387184024633072 no 2077 0.411193983710538 2900 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1717 st033143 58.0435 µM -0.225852268388618 0.386692038059853 no 2078 0.41065816144763 2960 674616 SGTC_2652 actinonin 100 µM -0.227334212088116 0.386162986073631 no 2079 0.410081936022435 2789 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2369 9071472 200 µM -0.227380213349586 0.386146567063828 no 2080 0.41006405241272 2956 17296037 SGTC_1885 st057546 99.9 µM -0.228069098048455 0.385900711155686 no 2081 0.409796261607 2955 702008 SGTC_1610 st001799 48.1 µM -0.228320709111406 0.385810925158241 no 2082 0.409698463081373 2779 621897 SGTC_2947 9072639 7.68 µM -0.228778492873205 0.385647583281553 no 2083 0.409520541849413 2891 16488146 SGTC_322 k048-0136 19.3 µM -0.228829703035113 0.385629312238289 no 2084 0.409500639778422 2903 6823282 SGTC_576 1073-0113 22.7 µM -0.228880005613866 0.385611365254605 no 2085 0.409481090653239 2854 5439563 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.230453768892304 0.38505000093458 no 2086 0.408869591877988 2744 4000243 SGTC_1690 st023502 41.2 µM -0.230836150531618 0.384913641007019 no 2087 0.408721047749151 2899 24207482 SGTC_2930 9013230 14.89 µM -0.231021488531061 0.384847553319329 no 2088 0.408649054051129 2952 2995857 SGTC_2156 5649887 115 µM -0.233915370495513 0.383816090082163 no 2089 0.407525340139075 2923 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_279 1273-0055 2.93 µM -0.234189910444788 0.383718278711175 no 2090 0.407418773774819 2885 2847562 SGTC_1491 4138-0063 26.5 µM -0.235311877332682 0.383318628451106 no 2091 0.406983338570736 2810 23883227 SGTC_1419 3993-2473 62.6 µM -0.235845435615736 0.383128615828069 no 2092 0.406776304967356 2851 704026 SGTC_2805 7950783 58.44 µM -0.239589776652439 0.38179596150545 no 2093 0.405324145510951 2949 1178958 YDL195W SEC31 SGTC_653 0203-0016 55.2 µM -0.240386721815612 0.381512499616799 no 2094 0.405015235460905 2881 295302 SGTC_1411 3909-8223 150 µM -0.241564144752102 0.381093823597233 no 2095 0.404558953839496 2953 X1411 SGTC_3189 9110682 49.47 µM -0.24180533208545 0.381008077728094 no 2096 0.404465503547693 2931 17122418 SGTC_1837 st055472 66.5 µM -0.242833331837538 0.380642673308321 no 2097 0.40406725659346 3004 676091 SGTC_3195 9113082 49.47 µM -0.243781013063153 0.380305912546743 no 2098 0.403700213072292 2883 17018038 SGTC_1798 st045719 60.953 µM -0.244312733361607 0.380117004189428 no 2099 0.403494311219221 2834 3980186 SGTC_1829 berberine 14.4 µM -0.244377947510216 0.380093837025407 no 2100 0.403469059718397 2996 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_885 0865-0106 16.8 µM -0.244771967579131 0.379953871531464 no 2101 0.403316500193037 2840 2793380 SGTC_2184 6075246 200 µM -0.246610067138796 0.379301141970743 no 2102 0.402605006349035 2898 2267320 SGTC_66 0109-0187 42.4 µM -0.246783223190908 0.379239670031062 no 2103 0.402537997474156 2753 759417 SGTC_1053 3366-3204 134 µM -0.248472476614313 0.378640130441197 no 2104 0.401884431470517 2900 3632071 YPR165W RHO1 SGTC_655 k060-0012 42 µM -0.249247911931771 0.378365015319106 no 2105 0.401584510107581 2855 5994525 SGTC_2511 berberine 10.47 µM -0.251986301452586 0.377393961784514 no 2106 0.400525826043021 2859 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1999 st074831 12.5 µM -0.253697877022814 0.376787417177102 no 2107 0.399864487152022 2879 17112523 SGTC_2740 felodipine 17.08 µM -0.254840031246034 0.376382831942505 no 2108 0.399423327649783 2967 3333 L-type calcium channel blocker SGTC_1128 3448-9350 235 µM -0.256066577426893 0.375948503751872 no 2109 0.398949714557011 2961 619386 SGTC_2033 5192550 145 µM -0.256290581460082 0.375869199377761 no 2110 0.398863234676679 2897 182073 SGTC_1853 st056710 91.2 µM -0.257665032880224 0.375382715843172 no 2111 0.398332717381111 3029 269167 SGTC_2340 7987427 183.45 µM -0.26129386990322 0.374099252175416 no 2112 0.396932946761854 3001 2239331 SGTC_1927 st060202 13.8 µM -0.262487332911752 0.373677446718367 no 2113 0.396472874982605 2832 688887 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.262525346520784 0.373664014057228 no 2114 0.396458223362663 2987 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1316 1272-0050 65.9 µM -0.26267578507133 0.373610855914958 no 2115 0.396400241129658 2868 7340392 SGTC_1546 5-methoxyflavanone 78.7 µM -0.263025887037765 0.373487155112566 no 2116 0.396265313221014 2938 147795 SGTC_366 0181-0206 4.31 µM -0.263429288199006 0.373344638379117 no 2117 0.396109859420729 3043 274874 SGTC_2828 7998861 71.43 µM -0.263764344898317 0.373226280083422 no 2118 0.395980755251646 2991 2988188 SGTC_3065 9113888 49.47 µM -0.264678269326589 0.372903498437959 no 2119 0.395628659602056 3070 16648368 SGTC_306 1672-3436 11.6 µM -0.266160297755297 0.372380262398411 no 2120 0.395057879130832 2965 6797378 SGTC_1494 4358-1428 177 µM -0.266855510559719 0.372134895829858 no 2121 0.394790206098059 3014 1564571 SGTC_941 3237-0776 460 µM -0.267971013020539 0.371741301842983 no 2122 0.394360815619119 3071 760008 SGTC_932 2857-0803 154 µM -0.268005791647366 0.37172903270157 no 2123 0.394347430339044 3105 674898 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.269122455206182 0.371335167450004 no 2124 0.393917725467676 3088 6728940 SGTC_154 3389-1638 511.116 µM -0.269201221440782 0.371307390409371 no 2125 0.393887420191486 2968 5238686 SGTC_93 0109-0045 59.227 µM -0.270154083035736 0.370971415359928 no 2126 0.393520858044478 2843 88733 SGTC_2933 9026794 32.47 µM -0.271405284681786 0.370530396213592 no 2127 0.393039668972878 2935 17586027 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.272249557176663 0.370232906089749 no 2128 0.392715069617357 2911 689007 SGTC_1722 st034304 3.6505 µM -0.273731589972245 0.369710880811795 no 2129 0.392145449663775 2893 4036148 YLR033W RSC58 SGTC_1450 4112-4260 37.6 µM -0.273888881169199 0.369655491265587 no 2130 0.392085008264515 3045 1633175 SGTC_3138 9097216 49.47 µM -0.274313765121445 0.369505883387788 no 2131 0.391921753529852 2830 25237486 SGTC_264 promethazine 12.5 mM -0.275607218126793 0.369050561296909 no 2132 0.391424882529408 2931 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1002 4049-0206 172 µM -0.276058062898193 0.368891897793182 no 2133 0.391251735220482 2885 4662749 SGTC_1412 3909-8563 178 µM -0.280117542017799 0.367464275185391 no 2134 0.389693663328672 2991 23767530 SGTC_2194 5927483 104.545 µM -0.280451326037795 0.367346972402728 no 2135 0.389565631881134 2894 760979 SGTC_18 0111-0177 500 nM -0.280829088823526 0.367214228954668 no 2136 0.389420745704423 2922 721752 SGTC_344 k064-0035 6.43 µM -0.281122798106008 0.367111032339821 no 2137 0.389308107813735 2901 5088750 SGTC_1642 st009582 77.7 µM -0.28306723949345 0.366428083030832 no 2138 0.388562647027362 3044 6739311 SGTC_1797 st048695 56.8 µM -0.28334655521581 0.366330013193366 no 2139 0.388455596477253 3042 592262 YIL048W NEO1 SGTC_92 0063-0024 660.874 µM -0.283927608218007 0.366126029115674 no 2140 0.388232929242689 2862 3594437 SGTC_2911 7942208 15.64 µM -0.284394213456045 0.365962250376369 no 2141 0.388054146501494 2989 1243384 SGTC_1729 st035615 45.989 µM -0.286014237883736 0.365393810518923 no 2142 0.387433608312604 3013 17385451 SGTC_499 genistein 192 µM -0.286508778390101 0.36522034323473 no 2143 0.387244235487157 2974 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1671 st016596 74.5 µM -0.287359063228167 0.36492215792078 no 2144 0.386918701360923 2951 2829167 SGTC_1897 st060201 15 µM -0.28744833618499 0.364890855635288 no 2145 0.386884527548571 2936 611878 SGTC_3082 9117008 49.47 µM -0.28892777742272 0.364372241984162 no 2146 0.386318323253446 2941 41448529 SGTC_1656 st012921 11 µM -0.289804700237047 0.364064956437234 no 2147 0.385982825921195 3028 6732821 SGTC_3205 9113483 49.47 µM -0.290790472550427 0.36371963288748 no 2148 0.3856057862186 3102 17018033 SGTC_616 4092-0450 108 µM -0.291485086957245 0.36347637062038 no 2149 0.385340173918735 2975 787165 SGTC_2391 6285546 200 µM -0.292823478306184 0.363007805245472 no 2150 0.384828540688052 2886 846083 SGTC_2495 cafestol 54.53 µM -0.293345261506665 0.362825186564701 no 2151 0.384629130408355 3114 16667697 An anti-infammatory. SGTC_2338 7999974 200 µM -0.295880628996447 0.361938279083903 no 2152 0.383660622449668 2989 315925 SGTC_3235 9132602 49.47 µM -0.296428560011121 0.361746702250684 no 2153 0.383451408569904 3041 4912240 SGTC_2458 5808907 16.39 µM -0.29675116708856 0.361633923153 no 2154 0.383328244940276 3093 2731747 SGTC_1500 4488-1866 171 µM -0.2972968241453 0.361443196140811 no 2155 0.383119953031027 3055 2900003 SGTC_3108 9121785 49.47 µM -0.297994050775173 0.361199540146885 no 2156 0.382853852132803 2844 17140271 SGTC_2241 6772625 37.8075 µM -0.298498948581305 0.36102313139957 no 2157 0.382661189235714 2889 2285411 SGTC_1861 st057647 17.4 µM -0.299058738170018 0.360827578292642 no 2158 0.382447614240855 3108 688668 SGTC_2985 9022375 71.43 µM -0.299450602551304 0.360690708684924 no 2159 0.382298128561807 3124 4939335 SGTC_220 paclitaxel 373.376 µM -0.299688582191055 0.360607596339334 no 2160 0.382207354315258 3039 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1418 3966-3099 2.4 µM -0.301020368985652 0.360142602863344 no 2161 0.381699481136534 3030 740335 SGTC_2207 7258803 200 µM -0.302435140201439 0.359648861945006 no 2162 0.381160185083253 3017 3666799 SGTC_570 0987-0065 62.6 µM -0.302739221958667 0.35954277101852 no 2163 0.381044302372462 2878 3104428 SGTC_2848 9016370 25.97 µM -0.303003480722467 0.359450582706311 no 2164 0.380943604494621 3044 7894410 SGTC_736 0958-0254 92.6 µM -0.303318127102876 0.359340827029466 no 2165 0.38082371653547 3051 6812352 SGTC_1812 st052057 4.327 µM -0.303929866744478 0.359127471817237 no 2166 0.38059066154026 2908 3645418 SGTC_538 2922-0838 53.3 µM -0.304249419185208 0.35901603961335 no 2167 0.380468938585286 3139 777039 SGTC_2074 5212007 75.395 µM -0.304420410275284 0.358956417662412 no 2168 0.380403810032895 3032 758611 SGTC_695 3505-6186 243 µM -0.304604787550313 0.358892132005409 no 2169 0.380333586634202 3051 1819379 SGTC_480 am 92016 50 µM -0.304661414807133 0.358872388940451 no 2170 0.380312019917302 3008 2129 K+ channel blocker. SGTC_3187 9109394 49.47 µM -0.304956730757511 0.358769433292136 no 2171 0.380199553689471 2980 17098090 SGTC_1270 0831-1170 17.3 µM -0.305642991862273 0.358530222537664 no 2172 0.379938241552245 2934 6764716 SGTC_2289 7946404 165.07 µM -0.305831346310341 0.358464577331898 no 2173 0.379866530175464 2922 1246120 YPR165W RHO1 SGTC_2408 sulbentine 18.36 µM -0.305940585674085 0.358426507195 no 2174 0.379824941836007 2979 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_42 0133-0086 60.653 µM -0.307069415500045 0.358033190198363 no 2175 0.379395268350635 2888 162923 Model of phenazepam hydroxylation. SGTC_1022 4477-0945 21.3 µM -0.307341146642597 0.357938533679618 no 2176 0.379291859862126 2944 4648966 SGTC_1120 ficusin 1.78878 µM -0.30958396438378 0.357157590594106 no 2177 0.378438676080474 3096 6199 A DNA cross-linker. SGTC_2413 inermin 26.06 µM -0.312727152865754 0.356064147689912 no 2178 0.377243982267624 3236 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1074 carmofur 3.8 µM -0.313931660390155 0.355645440215231 no 2179 0.376786471773379 2971 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1915 st067105 30.6 µM -0.314730077786299 0.355367992561418 no 2180 0.376483302590584 2941 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2258 7960471 200 µM -0.314862177187731 0.355322095799964 no 2181 0.376433150116566 3027 2974708 SGTC_3118 9124250 49.47 µM -0.315333835019911 0.355158239609247 no 2182 0.376254098903292 3011 1504786 SGTC_957 1187-1561 14.1 µM -0.31542787439372 0.355125573081123 no 2183 0.376218402765795 2977 1538454 SGTC_1643 st009866 20.2 µM -0.321734934366503 0.352937126119448 no 2184 0.373826755027817 3067 3156273 YOR207C RET1 SGTC_705 1124-0212 310 µM -0.323638447950674 0.352277588607361 no 2185 0.373105887999573 3122 9554485 SGTC_1824 st053723 68.6 µM -0.323969340208464 0.352162984890156 no 2186 0.372980623211803 3038 675225 SGTC_2993 9054257 71.4286 µM -0.324724521102721 0.351901480147313 no 2187 0.372694787190182 2945 6470217 YGL055W OLE1 SGTC_1385 3091-4834 14.1 µM -0.325074171949145 0.351780426440501 no 2188 0.372562468048513 3066 4072814 SGTC_1808 st050063 61.5 µM -0.32535155827594 0.351684402345003 no 2189 0.372457506825616 3139 4011993 SGTC_2531 methyl deoxycholate 70.07 µM -0.325879364408265 0.351501715412614 no 2190 0.372257814505068 2953 16667744 Haematoxylin. SGTC_472 calcifediol 10 µM -0.326907139553523 0.351146075115509 no 2191 0.371869060470481 3027 5283731 A vitamin D metabolite. SGTC_1706 st031321 9.9705 µM -0.327278898084936 0.351017467856218 no 2192 0.371728475641077 3085 6103185 SGTC_2203 7227154 166.4 µM -0.327527601026004 0.350931440341333 no 2193 0.371634435267416 3001 896304 SGTC_1758 st042942 75.2445 µM -0.32844537316578 0.350614044802164 no 2194 0.371287470578516 3026 669317 SGTC_1689 st020265 53.493 µM -0.329186270080967 0.350357894521871 no 2195 0.371007450019948 3109 5758320 YPR016C TIF6 SGTC_2616 abietic acid 100 µM -0.329906257440535 0.350109038489368 no 2196 0.370735397609484 3144 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.330592400679025 0.349871940203451 no 2197 0.370476193570193 3182 688751 SGTC_930 2810-3379 265 µM -0.332116350058169 0.349345545655728 no 2198 0.369900702311187 3200 1015764 SGTC_2331 7980721 200 µM -0.334821255382899 0.348411945336441 no 2199 0.368879962789117 3045 2981221 SGTC_75 0159-0059 199.013 µM -0.336550479527487 0.347815582603266 no 2200 0.368227896014982 3287 5377270 SGTC_2789 5281112 71.43 µM -0.336631351589601 0.347787701211826 no 2201 0.36819740953914 3039 765948 SGTC_335 4077-0256 27.6 µM -0.336793831349541 0.347731687299988 no 2202 0.368136161782591 3068 3121989 SGTC_312 4092-0653 6.84 µM -0.338019679094458 0.347309190930375 no 2203 0.367674178977313 3082 1148278 SGTC_874 0599-0792 117 µM -0.339327705790995 0.346858580212099 no 2204 0.367181436632283 3172 765305 SGTC_986 1493-0483 84 µM -0.342051478499992 0.34592094529826 no 2205 0.366156075946667 3116 40079 SGTC_848 0368-0089 85.6 µM -0.342797651247391 0.345664246352232 no 2206 0.365875346524984 3122 762535 SGTC_2913 7966556 36.57 µM -0.342800838218655 0.345663150119897 no 2207 0.365874147658128 3151 2976516 SGTC_2452 5863136 48.41 µM -0.34635460411021 0.344441557495645 no 2208 0.36453811842516 2975 2184096 SGTC_2651 TUB2.036 5 µM -0.346979360936134 0.344226967028866 no 2209 0.364303412124144 3183 15992207 YFL037W TUB2 SGTC_2751 anetholtrithion 17.25 µM -0.348439802907242 0.343725532493773 no 2210 0.363754957361953 3134 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3021 9087658 49.47 µM -0.349040548701796 0.343519349523959 no 2211 0.363529434063487 3130 25237042 SGTC_1929 genistein trimethyl ether 50.5 µM -0.350598373249832 0.342984902951585 no 2212 0.362944838562411 3210 136420 SGTC_1746 st038117 42 µM -0.350733621537873 0.342938517798429 no 2213 0.362894099787716 3107 2898218 SGTC_2974 9094440 9.66 µM -0.35172115538202 0.3425999020498 no 2214 0.362523696691922 3195 25236134 SGTC_2638 epoxomicin 18 µM -0.353283488671461 0.34206445150985 no 2215 0.36193796131324 3138 9915668 A protesome inhibitor. SGTC_1998 st075797 76.8 µM -0.354261833399691 0.34172930995831 no 2216 0.361571333949403 3151 24208315 SGTC_29 0299-0004 12.984 µM -0.355960786723502 0.341147613331215 no 2217 0.360934965964281 3062 16871 A napthoquinone isolated from Swertia calycina. SGTC_3208 9114115 49.47 µM -0.357045351763048 0.340776471434837 no 2218 0.360528927252118 3098 650895 SGTC_627 1391-0720 175 µM -0.359126245040038 0.340064814218565 no 2219 0.35975032437486 3115 997839 SGTC_1669 st015249 58.4 µM -0.359607830738456 0.339900194878858 no 2220 0.35957021337585 3132 722793 SGTC_1863 st057641 20.1 µM -0.362471806523637 0.338921840028385 no 2221 0.358499744142241 3116 3921635 SGTC_1058 3448-5425 97.3 µM -0.362511468990811 0.338908298648335 no 2222 0.35848492726771 3051 7279705 SGTC_2811 7967822 32.47 µM -0.362519880398681 0.338905426890279 no 2223 0.358481785010106 3189 2232244 SGTC_3128 9127691 49.47 µM -0.362600702051563 0.338877833861563 no 2224 0.358451592877068 3150 41316314 SGTC_3160 9100216 49.47 µM -0.366406038202607 0.337579648618755 no 2225 0.357031057364348 3079 17191039 SGTC_1260 0700-1617 7.75 µM -0.366544987801777 0.337532282592759 no 2226 0.35697922469739 3155 2853078 SGTC_119 0121-0043 24.815 µM -0.367097708186942 0.337343893230355 no 2227 0.35677306837117 3076 1092378 SGTC_201 4262-0159 12.803 µM -0.367575643212692 0.337181026595691 no 2228 0.356594839568029 3104 1341029 SGTC_972 1319-0219 195 µM -0.370988522654348 0.336018902941192 no 2229 0.355323040146137 3121 23903702 SGTC_702 1488-0190 94 µM -0.371376763041918 0.335886801730291 no 2230 0.355178465220806 3144 949357 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.372236581733238 0.335594315245451 no 2231 0.354858355798385 3073 2724278 An inhibitor of dopamine biosynthesis. SGTC_2221 6807166 181.081 µM -0.373898713067371 0.335029186694449 no 2232 0.354239836973966 3120 674925 SGTC_2315 7733312 200 µM -0.374762311761563 0.334735708387771 no 2233 0.353918622847816 3049 726316 SGTC_612 0302-0167 22.4 µM -0.375290610146043 0.334556225532039 no 2234 0.353722174353837 3127 235821 SGTC_2770 toltrazuril 17.5 µM -0.376182860012038 0.334253180504942 no 2235 0.353390478447821 3139 68591 Kills coccidiodes. SGTC_2046 4110841 106 µM -0.37704387070627 0.333960847984172 no 2236 0.353070501309062 3229 44119630 YMR134W ERG29 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.378005180350572 0.333634580721547 no 2237 0.352713372824532 3089 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_767 0929-0023 86 µM -0.37820997103404 0.333565091268637 no 2238 0.352637309424981 3157 1204563 SGTC_19 0279-0214 38.434 µM -0.378211388552753 0.333564610296925 no 2239 0.352636782950403 3078 3566274 YBR002C RER2 SGTC_3072 9116419 49.47 µM -0.378590152028173 0.333436103620267 no 2240 0.352496118140569 3104 17170162 SGTC_337 1315-0038 354 µM -0.379047489625765 0.333280964404034 no 2241 0.352326299431025 3088 1626437 SGTC_3090 9117696 49.47 µM -0.380925918710882 0.332644058302471 no 2242 0.351629109754261 3113 7923821 SGTC_32 0928-0142 34.1 µM -0.381030863670843 0.332608489554703 no 2243 0.35159017352265 3168 2244242 SGTC_1440 4100-1550 40 µM -0.381264551749255 0.332529291619498 no 2244 0.351503477162118 3117 742806 SGTC_2995 9067767 71.4286 µM -0.382882087594038 0.331981306585455 no 2245 0.35090359661358 3136 11673567 SGTC_1866 st057638 64 µM -0.384226761327164 0.331526034476959 no 2246 0.350405192565652 3084 688802 SGTC_3222 9128301 49.47 µM -0.386481742330364 0.330763114323594 no 2247 0.349569960871586 3063 4911358 SGTC_1996 st072960 66.8 µM -0.38804693315122 0.330233981343774 no 2248 0.348990650968899 3203 1719405 SGTC_339 3091-4833 71.4 µM -0.389251150385694 0.329827111039899 no 2249 0.348545184305908 3079 3240077 SGTC_1442 4112-3290 3 µM -0.389677116654732 0.329683237475482 no 2250 0.348387659890108 3079 704353 SGTC_1590 st077108 57.8 µM -0.389755885583991 0.329656635390603 no 2251 0.348358533617334 3190 5489485 SGTC_2698 st077697 67.5 µM -0.390168231648738 0.329517390677305 no 2252 0.348206075606863 3112 3154499 SGTC_3188 9110789 49.47 µM -0.391258645209323 0.329149283984352 no 2253 0.347803031804818 3250 849217 SGTC_2794 7785382 27.27 µM -0.391577103071081 0.329041808779329 no 2254 0.347685354326096 3204 2205081 SGTC_2712 st079126 47.7 µM -0.391679167299198 0.329007366477644 no 2255 0.347647642359107 3071 3152970 SGTC_1609 st001574 46.4 µM -0.391821129798404 0.328959462633707 no 2256 0.347595190786925 3081 3960012 SGTC_2786 7743617 45.45 µM -0.392921593941844 0.328588217213018 no 2257 0.34718869600201 3109 583674 SGTC_760 0568-0725 82.9 µM -0.393992116388482 0.32822723500335 no 2258 0.346793429844615 3216 3916171 SGTC_3018 9082602 49.47 µM -0.394530765909245 0.328045661971596 no 2259 0.346594608722979 3175 17332089 SGTC_1195 1502-0147 41.1 µM -0.395164233420138 0.327832178790346 no 2260 0.346360843359519 3111 817940 SGTC_1724 st037281 8.293 µM -0.396610060536339 0.327345135286117 no 2261 0.345827516270012 3063 574124 YDL195W SEC31 SGTC_1513 0337-0559 19 µM -0.397394495486385 0.327081012215583 no 2262 0.345538287001411 3109 775073 SGTC_1631 benzylvanillin 81.9 µM -0.397697209768107 0.326979109987284 no 2263 0.345426697217121 3224 75506 SGTC_855 0428-0020 25 µM -0.397868552731682 0.326921436794066 no 2264 0.345363540889837 3124 6812414 SGTC_882 0843-0131 351 µM -0.398532852816784 0.326697875768248 no 2265 0.345118723267612 3243 5425421 SGTC_795 0685-0265 78 µM -0.400677093052503 0.325976686117274 no 2266 0.344328939019291 3117 302754 SGTC_2432 5630864 12.22 µM -0.40090964549141 0.325898508930925 no 2267 0.344243324101111 3226 5714970 SGTC_3050 9093513 49.47 µM -0.403345052625538 0.325080258094671 no 2268 0.343347201460215 3129 25236664 SGTC_1700 st030840 7.9285 µM -0.406630841314091 0.323977631242133 no 2269 0.342139570950732 3215 5499307 SGTC_2067 5224629 34.075 µM -0.406730577619378 0.323944186358214 no 2270 0.342102939886764 3256 2835000 SGTC_628 1636-0253 16 µM -0.406882040377792 0.323893398600687 no 2271 0.342047313617684 3182 4456143 SGTC_721 1187-1332 279 µM -0.407312901112966 0.323748942399007 no 2272 0.341889094292799 3061 25730 SGTC_3225 9130819 49.47 µM -0.408561747087606 0.323330387451561 no 2273 0.341430653951547 3243 4547121 SGTC_565 1418-0001 44.5 µM -0.41140897187407 0.322376966734888 no 2274 0.340386338135995 3277 2862145 SGTC_2989 9073649 71.4286 µM -0.41151691403198 0.322340844186177 no 2275 0.340346770714173 3247 21367202 SGTC_2772 vinpocetine 57.06 µM -0.412948986500978 0.321861763911683 no 2276 0.339821994797387 3319 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1867 st057372 64 µM -0.416312076589982 0.320737852802761 no 2277 0.338590828341163 3211 688837 SGTC_212 3807-4682 38.772 µM -0.416627985693126 0.320632363303254 no 2278 0.33847526805593 3214 3125501 YBL034C STU1 SGTC_2765 myclobutanil 7.74 µM -0.416715209688874 0.320603239705569 no 2279 0.338443363994155 3239 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_486 niguldipine 82 µM -0.417257764016254 0.320422108697195 no 2280 0.338244939069633 3126 1236 A calcium channel blocker. SGTC_2276 7947513 42.08 µM -0.41736311976958 0.320386940782791 no 2281 0.33820641318998 3181 2105100 SGTC_1082 camptothecin 424.86 nM -0.417825944288948 0.320232468347141 no 2282 0.33803719028043 2940 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1728 st035614 33.7865 µM -0.418302827970289 0.320073336103986 no 2283 0.337862861135471 3178 15945546 SGTC_1359 1582-0056 520 nM -0.418505419611109 0.320005742919789 no 2284 0.337788812449794 3233 3661189 SGTC_190 3970-0790 3.722 µM -0.418535717261069 0.319995634849225 no 2285 0.337777738982821 3204 2832352 SGTC_2666 tannic acid 100 µM -0.421171145906825 0.319116900522305 no 2286 0.336815056252272 3235 16134267 A thiamine antagonist. SGTC_2087 5276107 200 µM -0.421985076686347 0.31884571554313 no 2287 0.336517955083296 3112 144405 SGTC_359 0081-0058 15.9 µM -0.422164905709889 0.318785813287617 no 2288 0.336452327614047 3483 3494159 SGTC_2040 5100729 123 µM -0.424422620102945 0.318034156713985 no 2289 0.3356288134596 3132 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_97 0535-0701 19.132 µM -0.424550176963089 0.317991711774158 no 2290 0.335582309877591 3168 2832013 YGL099W LSG1 SGTC_63 0099-0242 26.702 µM -0.424648498268785 0.317958996687066 no 2291 0.335546466460986 3258 3898502 YLR359W ADE13 SGTC_1913 st060213 96.1 µM -0.424671255106895 0.317951424858858 no 2292 0.335538170579893 3316 688959 SGTC_2688 kanamycin b 96.69 µM -0.425352181840121 0.317724896958691 no 2293 0.335289979561816 3330 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.4279530480926 0.316860279937484 no 2294 0.33434265207173 3262 6708760 SGTC_3086 9117350 49.47 µM -0.428170300090933 0.316788103090252 no 2295 0.334263568826941 3205 2679265 SGTC_1740 st038286 13.222 µM -0.428219885434215 0.316771630507957 no 2296 0.334245519990138 3350 716786 SGTC_3019 9081971 49.47 µM -0.431038305427018 0.315835930554925 no 2297 0.33322025914961 3332 16451803 SGTC_620 0109-0052 432 µM -0.433915366580703 0.314881977804287 no 2298 0.33217495027036 3311 493037 SGTC_174 3553-0389 74.3 µM -0.435061705612731 0.314502227306118 no 2299 0.331758819329937 3301 738071 SGTC_1118 chelidonine 707.474 nM -0.435234888388981 0.314444873677532 no 2300 0.331695970520465 3262 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1146 3579-1023 7 µM -0.437714169966839 0.313624291651448 no 2301 0.330796748144615 3285 X1146 SGTC_2360 9040895 200 µM -0.437848539679993 0.313579844822408 no 2302 0.330748040779015 3206 4914414 SGTC_1705 st027868 56.3335 µM -0.438396780884238 0.313398525586787 no 2303 0.33054933980176 3235 292948 SGTC_1831 st055328 12 µM -0.439085437876574 0.313170830678627 no 2304 0.330299815107993 3283 1103068 SGTC_2997 9067075 71.4286 µM -0.440264033567058 0.312781309588188 no 2305 0.3298729434508 3234 27209819 SGTC_3270 9137563 49.47 µM -0.441684237735961 0.312312215493562 no 2306 0.329358858654025 3238 17015724 SGTC_1290 0986-0249 10.2 µM -0.442411388765371 0.312072154810709 no 2307 0.329095769618299 3222 53329 SGTC_2059 5238311 157 µM -0.442747553796174 0.311961200692717 no 2308 0.328974171028636 3122 703021 SGTC_3308 9128332 17.569 µM -0.44325892288139 0.311792451707761 no 2309 0.328789231826641 3314 17332805 YDL196W YDL196W SGTC_453 enantio-paf c16 10 µM -0.443544915007551 0.31169809310286 no 2310 0.328685819609142 3277 13871343 A lipid and platelet activating factor SGTC_1147 3809-1045 12.3 µM -0.446162815884705 0.310834932990957 no 2311 0.32773982029821 3207 325925 SGTC_2359 9039622 200 µM -0.446184358602788 0.310827834350198 no 2312 0.327732040239509 3160 6463596 SGTC_1969 st069479 40.1 µM -0.446555011364096 0.310705709871723 no 2313 0.327598192325493 3305 3895485 SGTC_2760 etidronate 98.04 µM -0.447790882840966 0.310298659661585 no 2314 0.327152061944633 3172 3305 A chelator and antioxidant. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.448148835177896 0.310180806800143 no 2315 0.327022892792054 3305 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3295 9122362 53.5725 µM -0.448854308271118 0.30994859266589 no 2316 0.326768379451759 3280 4730473 SGTC_2313 7726885 200 µM -0.448934538829815 0.309922188704198 no 2317 0.326739439795649 3271 726423 SGTC_2957 9076800 11.52 µM -0.44921013803318 0.30983149618366 no 2318 0.326640037408368 3197 16459615 SGTC_2479 5617353 43.85 µM -0.450059866853959 0.309551945424632 no 2319 0.326333636963653 3335 2731746 SGTC_2421 5690543 90.72 µM -0.452236537624885 0.308836349180784 no 2320 0.325549294470442 3280 3397993 SGTC_978 1416-0512 87.4 µM -0.453782128051261 0.308328665186505 no 2321 0.324992824098561 3291 6814003 SGTC_72 0744-0168 198.391 µM -0.456849479944595 0.307322210017516 no 2322 0.323889619154268 3112 677577 SGTC_2198 6589944 200 µM -0.457118777358314 0.30723391763074 no 2323 0.323792837194243 3265 5290268 SGTC_881 0833-0569 170 µM -0.457911022940729 0.306974235213049 no 2324 0.323508183615787 3217 5418700 SGTC_3040 9091894 49.47 µM -0.460350734675537 0.306175154514029 no 2325 0.322632245136832 3181 25236966 SGTC_1061 3448-9325 110 µM -0.460669586581378 0.306070788688408 no 2326 0.32251783915007 3299 723482 SGTC_1344 1488-0097 29.1 µM -0.461996383210299 0.305636673953003 no 2327 0.322041957059866 3310 747966 SGTC_3302 9125395 16.351 µM -0.462039965679816 0.305622418828749 no 2328 0.322026330280568 3208 17599668 SGTC_2729 fluphenazine 10.66 µM -0.462404852080583 0.305503081920795 no 2329 0.321895510224757 3193 3372 An atypical antipsychotic. SGTC_2467 5474540 200 µM -0.462678074092993 0.305413737581583 no 2330 0.321797568382243 3192 5413519 SGTC_2533 agelasine 13.65 µM -0.462975521880338 0.305316484523776 no 2331 0.321690956406707 3414 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2621 lithochol-11-enic acid 100 µM -0.463250563685411 0.305226569517047 no 2332 0.321592388302386 3345 6708711 SGTC_533 1222-0222 6.71 µM -0.463524856006703 0.30513691123159 no 2333 0.321494101301104 3375 3982874 SGTC_1119 parthenolide 318.541 nM -0.463888130896825 0.30501818509776 no 2334 0.321363948464356 3383 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1994 st072947 40.9 µM -0.464016124546296 0.30497635887789 no 2335 0.321318096578584 3320 5286565 YDL195W SEC31 SGTC_1201 1889-3372 45.9 µM -0.464482909503309 0.304823842821979 no 2336 0.321150900653846 3197 5392199 SGTC_2513 baicalein 25.65 µM -0.4649422985352 0.304673776396232 no 2337 0.320986389236715 3252 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1898 st060199 18.6 µM -0.465760514650373 0.304406575038923 no 2338 0.320693465590974 3212 688866 SGTC_13 0199-0087 65 µM -0.468155562671257 0.30362503465886 no 2339 0.319836673802548 3294 4589825 SGTC_1977 st070720 65.3 µM -0.469097685151739 0.303317851533049 no 2340 0.319499906811671 3323 682188 SGTC_3031 9088762 49.47 µM -0.46925091226345 0.303267904303615 no 2341 0.319445148979282 3170 205253 SGTC_2971 9092186 9.93 µM -0.469571450403877 0.30316343082254 no 2342 0.319330612965195 3174 25236400 SGTC_386 1509-0011 3.07 µM -0.469916378664481 0.303051025815221 no 2343 0.319207381028314 3253 3107280 SGTC_1633 st005664 67.9 µM -0.470044503049038 0.303009277470322 no 2344 0.319161611332654 3186 2063822 SGTC_1922 5578187 25 µM -0.47111787532911 0.30265962851053 no 2345 0.318778280374479 3401 1350412 SGTC_2023 5144124 124 µM -0.471763060129529 0.302449547826068 no 2346 0.318547960250629 3200 2830192 SGTC_845 0330-0138 4.51 µM -0.472084543506445 0.302344893009748 no 2347 0.318433222251163 3286 9039800 SGTC_275 trichlorophene 5.69 µM -0.472690408022667 0.302147705705863 no 2348 0.318217035444028 3325 62616 SGTC_2584 androsterone 48.74 µM -0.473654920300135 0.301833910508762 no 2349 0.317873002364805 3325 2754130 A steroid. SGTC_2214 7179297 48.276 µM -0.474148385800211 0.301673422704438 no 2350 0.317697048290715 3281 769744 SGTC_3076 9116187 49.47 µM -0.474375599129592 0.301599539929598 no 2351 0.317616045095616 3307 27241210 SGTC_3150 9097574 49.47 µM -0.474441967983758 0.301577960358941 no 2352 0.317592385766514 3339 17217476 SGTC_2122 5258151 111.688 µM -0.474844886066761 0.301446968047311 no 2353 0.317448768549733 3239 2173356 SGTC_1023 4482-3888 16 µM -0.476540769387636 0.300895901993139 no 2354 0.316844584688134 3376 3303168 SGTC_9 0092-0002 10.449 µM -0.476859554006864 0.300792365789598 no 2355 0.316731067343505 3313 759368 SGTC_1200 1643-0193 18.4 µM -0.477505409483825 0.300582651428216 no 2356 0.316501134874725 3352 5403974 SGTC_1019 4262-0212 3.4 µM -0.477643412775303 0.300537849233757 no 2357 0.316452013201698 3331 4677213 SGTC_3085 9117376 49.47 µM -0.478554858236635 0.300242028014949 no 2358 0.316127669485236 3336 16480349 SGTC_1162 k048-0130 20.1 µM -0.479413789412799 0.299963371512477 no 2359 0.315822142761629 3247 6797406 SGTC_2148 5546263 113.568 µM -0.480182343314305 0.299714134678489 no 2360 0.315548870373979 3211 792097 SGTC_983 1491-0821 12.2 µM -0.481205869047694 0.299382357924056 no 2361 0.315185095001455 3334 46495113 SGTC_448 monastrol 171 µM -0.48309720712484 0.298769717714581 no 2362 0.314513358512265 3301 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1276 0871-0068 94.2 µM -0.483881367455956 0.298515880540717 no 2363 0.314235032257155 3298 3414906 SGTC_1085 doxorubicin 7.67 µM -0.485761338215689 0.297907723204767 no 2364 0.313568194359462 3359 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2549 cedrol 20.94 µM -0.488712851782067 0.29695407067181 no 2365 0.312522501897762 3354 6708665 A sedative which affects the nervous system. SGTC_2255 7941087 197.44 µM -0.490779105055271 0.296287283536686 no 2366 0.311791345049716 3381 935561 SGTC_2233 sulbentine 40.3845 µM -0.491626382440764 0.296014062809865 no 2367 0.311491744672971 3317 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_884 0851-0618 334 µM -0.491667030161312 0.296000958086163 no 2368 0.311477374625779 3356 9642473 SGTC_221 trifluoperazine 10.304 µM -0.492329974387677 0.295787264124963 no 2369 0.311243046810891 3342 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_88 0180-0332 8.668 µM -0.494002066957953 0.295248595568925 no 2370 0.310652359865537 3255 3101745 SGTC_1112 tnp00069 1.16933 µM -0.495174900940698 0.294871033986005 no 2371 0.3102383330077 3343 145826 SGTC_1903 st060211 78.3 µM -0.495882752239199 0.294643268504944 no 2372 0.309988567855959 3393 688960 SGTC_2430 5571206 200 µM -0.495992028819907 0.294608113785995 no 2373 0.309950017450225 3411 1731771 SGTC_1756 st041558 35.5 µM -0.497722330984856 0.29405172665016 no 2374 0.309339883100545 3428 3955792 SGTC_52 0329-0193 875 nM -0.501972958934517 0.292686982821438 no 2375 0.30784327124115 3454 3739292 SGTC_291 SEC14.278 35.5 µM -0.502223995619778 0.292606474871749 no 2376 0.307754982807546 3386 1068044 SGTC_1605 st000082 49.1 µM -0.502298083434892 0.292582716732823 no 2377 0.307728928594845 3379 1114022 SGTC_2658 polymyxin b sulfate 77.05 µM -0.503715360188667 0.292128403631691 no 2378 0.307230706449051 3323 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2119 5528445 120.635 µM -0.505328552420249 0.291611688998479 no 2379 0.306664045908106 3407 791935 SGTC_1299 1079-1439 3.74 µM -0.505448247054951 0.29157336711406 no 2380 0.306622019569234 3297 323161 SGTC_2541 muurolladie-3-one 83.07 µM -0.506962668976532 0.291088707030437 no 2381 0.306090506127275 3438 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2686 alizarin 95.37 µM -0.506965944411057 0.29108765920182 no 2382 0.306089356996737 3293 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1432 4049-0298 68.4 µM -0.50781018538607 0.290817640869189 no 2383 0.305793233054693 3375 741646 SGTC_3252 9135871 49.47 µM -0.507989413967884 0.290760332257187 no 2384 0.305730383594443 3400 17682838 SGTC_1337 1486-1011 40.3 µM -0.508061431980285 0.290737305875395 no 2385 0.305705130901243 3387 X1337 SGTC_3326 9140064 16.379 µM -0.50879156356379 0.290503908429925 no 2386 0.30544916673277 3262 1868434 SGTC_3267 9137951 49.47 µM -0.508870473666636 0.290478688890798 no 2387 0.30542150869923 3253 16643986 SGTC_781 4335-2806 94.4 µM -0.508934182348314 0.290458328448562 no 2388 0.305399179582264 3411 845254 SGTC_2048 5246248 200 µM -0.509367898627439 0.290319736285985 no 2389 0.305247186553627 3403 677046 SGTC_3058 9093861 49.47 µM -0.511325877252518 0.289694458483833 no 2390 0.3045614439925 3426 17217477 SGTC_2124 5246320 200 µM -0.513573272370422 0.288977535971244 no 2391 0.303775185092591 3370 579342 SGTC_2568 diosmetin 100 µM -0.514157496655043 0.288791304314245 no 2392 0.303570940635045 3447 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_685 1278-0033 54.9 µM -0.51436335833667 0.288725695785915 no 2393 0.303498986128432 3426 3590572 SGTC_3004 9076122 71.4286 µM -0.5160265097241 0.288195903701373 no 2394 0.302917947070536 3405 44782551 SGTC_1397 3532-0190 20.1 µM -0.51658529325693 0.288018007794344 no 2395 0.302722842100142 3255 5322280 SGTC_878 0828-0289 13.7 µM -0.517764086561545 0.287642893926375 no 2396 0.30231143914289 3339 745350 YLR208W SEC13 SGTC_2449 5812982 45.77 µM -0.518567147582859 0.287387477336751 no 2397 0.302031311785798 3379 776185 SGTC_2628 lathosterol 100 µM -0.518718321419807 0.287339407928814 no 2398 0.301978591688498 3436 6710616 SGTC_2890 9046729 58.44 µM -0.520396688640443 0.286805985866809 no 2399 0.301393558786773 3274 903329 SGTC_130 0136-0219 337.655 µM -0.520416166178196 0.286799798232392 no 2400 0.301386772445653 3337 234244 SGTC_2030 5175110 200 µM -0.521705549246008 0.286390327145499 no 2401 0.300937680184264 3438 2831986 SGTC_91 0417-1751 58.384 µM -0.522166949577374 0.286243867074669 no 2402 0.300777047740026 3422 6795624 SGTC_258 haloperidol 50.781 µM -0.526658459129686 0.284820010604619 no 2403 0.299215393978041 3351 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_317 4495-0002 170 µM -0.527508807723606 0.284550821976424 no 2404 0.298920150831437 3375 15991618 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.527715757208163 0.284485327881463 no 2405 0.298848317482885 3388 75037 A free radical scavenger. SGTC_2335 9018011 154.17 µM -0.528712921680667 0.284169852407444 no 2406 0.298502305998459 3373 6458208 SGTC_244 nsc-207895 1.295 µM -0.530652578158104 0.283556677960385 no 2407 0.297829776745653 3307 42640 SGTC_3275 9138069 49.47 µM -0.531849738491072 0.283178541984135 no 2408 0.297415035355562 3399 17617007 SGTC_2121 5257820 149.641 µM -0.534994710788743 0.28218632282733 no 2409 0.296326757368282 3458 791256 SGTC_1365 1672-3266 55.4 µM -0.535069264794329 0.282162821822945 no 2410 0.296300981064223 3441 6415873 SGTC_1190 1486-1332 13 µM -0.535159239133999 0.282134461256758 no 2411 0.29626987470266 3387 4150046 SGTC_1020 4335-0961 93.3 µM -0.535591608499704 0.281998194434321 no 2412 0.296120414780878 3259 669075 SGTC_398 bronopol 33.3 µM -0.536267327460578 0.28178529632857 no 2413 0.29588690393921 3314 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1821 st053465 65.6 µM -0.537326195251641 0.281451835793041 no 2414 0.2955211570456 3374 675086 SGTC_2213 7173844 200 µM -0.537507304016824 0.28139481977133 no 2415 0.295458620516737 3345 892728 SGTC_750 4073-0104 132 µM -0.538163714012633 0.281188217820585 no 2416 0.295232014358709 3345 22330957 SGTC_1077 5-fluorocytosine 377 nM -0.538359892696763 0.281126485726049 no 2417 0.295164304995225 3405 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1992 st073643 23.3 µM -0.538842106041072 0.280974774133268 no 2418 0.294997903655294 3393 3161292 SGTC_1920 st075728 45.7 µM -0.539580437679461 0.280742560557787 no 2419 0.294743205242319 3474 3400306 SGTC_1807 st050092 58.9 µM -0.540183216901334 0.280553048581848 no 2420 0.29453534285545 3339 5008496 SGTC_958 1222-0007 33 µM -0.5411712443591 0.280242549684794 no 2421 0.294194777858972 3490 7312461 SGTC_944 3370-0224 231 µM -0.543150921790044 0.27962091486088 no 2422 0.293512947266911 3380 4580514 SGTC_3238 9133470 49.47 µM -0.543949264147255 0.279370418385231 no 2423 0.293238193412821 3465 3534688 SGTC_999 SEC7.066 22.7 µM -0.544122960046067 0.279315932136747 no 2424 0.293178430822667 3381 740511 YDR170C SEC7 SGTC_1430 4049-0248 69.1 µM -0.549817491950298 0.277532493349169 no 2425 0.291222279943616 3469 22774488 SGTC_2597 laccaic acid a 100 µM -0.551280517513277 0.277075196651763 no 2426 0.290720695901328 3412 5491415 A textile dye. SGTC_1360 1598-0022 39.8 µM -0.551338690774128 0.277057021109202 no 2427 0.290700760120665 3432 761525 SGTC_3271 9137798 49.47 µM -0.551672743374825 0.276952661650346 no 2428 0.290586293798145 3417 6498326 SGTC_370 0180-0345 38.7 µM -0.55235754379746 0.27673878725868 no 2429 0.290351706325542 3351 3989527 SGTC_1502 4534-4282 27.7 µM -0.553725287891042 0.276311860728377 no 2430 0.289883433061305 3390 3278949 SGTC_3081 9117243 49.47 µM -0.553826147657824 0.276280391239534 no 2431 0.289848915825147 3495 45595589 SGTC_441 propafenone 146 µM -0.554690487368868 0.276010778740939 no 2432 0.289553191945607 3397 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2657 nystatin 74.44 µM -0.554884710518159 0.275950212719129 no 2433 0.289486760230617 3453 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1142 3253-1408 9.78 µM -0.556618968564202 0.275409695934261 no 2434 0.288893895484801 3464 256655 SGTC_3063 1327-0034 4 µM -0.557479128395888 0.275141803020176 no 2435 0.28860005770458 3411 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1456 k015-0012 13 µM -0.557786072050407 0.275046237872688 no 2436 0.288495237284536 3523 2989616 SGTC_2219 9098279 200 µM -0.558942598583464 0.274686306895768 no 2437 0.288100447873183 3455 902349 SGTC_1815 st051655 58.2 µM -0.563294345302104 0.273334053291703 no 2438 0.286617234005825 3435 5984156 SGTC_1887 st057648 70.8 µM -0.56407702252809 0.273091195900258 no 2439 0.28635085741623 3474 688672 SGTC_2263 7948595 193.29 µM -0.565509431152641 0.27264701010661 no 2440 0.285863655634637 3449 2971371 SGTC_865 0488-0499 301 µM -0.56581806816496 0.272551349632386 no 2441 0.285758731286744 3502 9634651 SGTC_1127 asiatic acid 681.4 nM -0.56767340981029 0.271976647310706 no 2442 0.285128375036231 3380 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1482 3346-2049 8.48 µM -0.568431372929282 0.271742037577029 no 2443 0.284871046294113 3453 3826804 SGTC_2262 9014885 67.46 µM -0.568865520402985 0.271607702778616 no 2444 0.284723702998107 3430 6457424 SGTC_590 k048-0076 22.4 µM -0.568918696292833 0.271591251259483 no 2445 0.284705658380505 3474 6832814 SGTC_1232 0279-0259 161 µM -0.568931024023967 0.271587437385609 no 2446 0.284701475186767 3434 1560000 SGTC_3008 9078912 71.4286 µM -0.570515713701708 0.271097398496205 no 2447 0.284163983701863 3455 16648731 SGTC_729 4092-0585 94.1 µM -0.571295826752843 0.270856323604996 no 2448 0.283899565063909 3390 2169061 SGTC_812 4251-0442 148 µM -0.57158811749891 0.27076602584857 no 2449 0.283800523706626 3482 5723007 SGTC_839 0122-0028 230 µM -0.572700798996154 0.270422421277628 no 2450 0.283423648190915 3401 759448 SGTC_326 k292-0812 17.5 µM -0.57596512555383 0.269415631321243 no 2451 0.282319377096899 3463 3579357 SGTC_2478 5763493 32.33 µM -0.576343691806248 0.269298994891104 no 2452 0.282191448073113 3437 1365576 YLR208W SEC13 SGTC_1141 3253-0389 52.6 µM -0.577098559780357 0.269066495349246 no 2453 0.281936438601586 3466 5402031 SGTC_2832 7992762 51.95 µM -0.578185219371855 0.268731980876199 no 2454 0.28156953834434 3279 2985177 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.578871753969946 0.26852074759224 no 2455 0.281337855248768 3400 6708630 An antioxidant. SGTC_1062 mesoridazine 14.2 µM -0.579696384250422 0.268267135350429 no 2456 0.281059691052715 3492 4078 A neuroleptic. SGTC_754 3474-0146 171 µM -0.582646435735897 0.267360844802983 no 2457 0.280065669365399 3345 24762078 SGTC_2296 7971656 126.45 µM -0.58484353010146 0.266686876536186 no 2458 0.279326465865425 3461 666570 SGTC_852 0418-0143 439 µM -0.587722113218011 0.265805160257786 no 2459 0.27835941514502 3514 5369229 SGTC_424 splitomicin 100 mM -0.590573868432926 0.264933120755877 no 2460 0.277402989053113 3467 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1523 st012844 44.7 µM -0.590684648271359 0.264899274699242 no 2461 0.277365867980616 3496 4274103 SGTC_2220 6782180 200 µM -0.591607864396878 0.264617294202929 no 2462 0.277056603183635 3454 833803 SGTC_256 clotrimazole 625 nM -0.592972069202043 0.264200900980314 no 2463 0.276599922377682 3486 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1176 0848-0131 83.3 µM -0.593553518797202 0.264023527886414 no 2464 0.27640538868528 3511 6769040 SGTC_3209 9113616 49.47 µM -0.594438846673092 0.263753572319476 no 2465 0.276109316358787 3557 16649353 SGTC_982 1491-0518 27.5 µM -0.596371022277846 0.26316489954601 no 2466 0.275463697226275 3437 3091256 SGTC_1995 st072814 61.1 µM -0.596470545357873 0.263134596199961 no 2467 0.275430462604132 3415 5769371 SGTC_2310 7668677 200 µM -0.597906404071085 0.262697596379875 no 2468 0.274951193266927 3577 2197143 SGTC_2201 6605497 169.863 µM -0.598774957079263 0.262433434899525 no 2469 0.274661482149529 3492 670741 SGTC_313 3474-0040 5.03 µM -0.600580152185778 0.261884838757439 no 2470 0.274059830421966 3490 1043375 YIL048W NEO1 SGTC_156 3474-0145 5.642 µM -0.600906885515365 0.261785607871712 no 2471 0.27395100342815 3498 2265471 SGTC_2008 4012253 172 µM -0.601520798959342 0.261599210832269 no 2472 0.273746581453177 3493 603940 SGTC_2066 5222451 176 µM -0.601925165461625 0.261476473875182 no 2473 0.273611976012243 3516 2281147 SGTC_1267 0828-0272 9.49 µM -0.602612656923657 0.261267868173347 no 2474 0.273383199192022 3580 745334 SGTC_3317 9138495 8.753 µM -0.603228286196555 0.261081140224226 no 2475 0.273178416400906 3538 17020139 SGTC_463 ikarugamyin 104 µM -0.603706130962221 0.260936251318952 no 2476 0.273019518629778 3530 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1327 1436-0082 2.18 µM -0.603863955283654 0.260888405965812 no 2477 0.272967047358727 3462 15992205 SGTC_3242 9133940 49.47 µM -0.603961870756761 0.260858724593797 no 2478 0.272934496275387 3571 17248444 SGTC_1680 diphenhydramine 100 µM -0.605056733673213 0.260526954291766 no 2479 0.272570650482911 3447 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2186 6124449 200 µM -0.60613825433935 0.260199440455218 no 2480 0.272211475162295 3497 3834182 YLR033W RSC58 SGTC_2924 9010168 62.78 µM -0.607224922733826 0.25987058159014 no 2481 0.271850827334297 3528 2993929 SGTC_2411 st077133 39.94 µM -0.607251796039126 0.259862451629335 no 2482 0.271841911528088 3635 1403142 YNL221C POP1 SGTC_1521 st012942 49.4 µM -0.607308153195429 0.259845402367435 no 2483 0.271823214282603 3532 24207259 SGTC_2612 dictamnine 15.46 µM -0.607914265842587 0.25966207663346 no 2484 0.271622168708062 3468 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_385 1494-0393 12.4 µM -0.608117941195441 0.259600487673412 no 2485 0.271554626885922 3496 3090647 SGTC_1441 4106-0040 13 µM -0.608504932306098 0.259483487030745 no 2486 0.271426317838902 3539 2904180 SGTC_1554 st069299 38.7 µM -0.608729209336384 0.259415692884444 no 2487 0.271351971373924 3531 24207999 SGTC_1711 st032263 62.8 µM -0.609637571406902 0.259141208074153 no 2488 0.271050958721403 3505 3958979 SGTC_1366 1683-0113 21.9 µM -0.610845609924099 0.258776401125242 no 2489 0.270650897618689 3518 708623 SGTC_1189 1431-2119 7.28 µM -0.61402540339577 0.257817430023585 no 2490 0.269599270262638 3579 3107275 SGTC_784 4579-0127 173 µM -0.615517904252002 0.257367954223617 no 2491 0.269106374491144 3585 1948547 SGTC_1422 4031-0024 15.5 µM -0.617342601678216 0.256818989139835 no 2492 0.268504386371194 3512 782427 SGTC_1936 st074407 74.3 µM -0.619270772812269 0.256239556674553 no 2493 0.26786899761562 3519 809813 SGTC_1506 4226-2149 212 µM -0.619558919431705 0.256153024642566 no 2494 0.267774109968035 3535 991114 SGTC_1006 4099-6547 255 µM -0.620333777874987 0.255920405951325 no 2495 0.267519030516155 3557 3146833 SGTC_739 1486-1183 203 µM -0.623440979566406 0.254988707677268 no 2496 0.266497387830851 3562 4346692 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.624204697015208 0.254759978065213 no 2497 0.266246581293474 3541 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1568 digitonin 820 nM -0.625563200050456 0.254353378743234 no 2498 0.265800741308978 3588 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1618 st003135 44.5 µM -0.626293933611616 0.254134811304389 no 2499 0.265561082309913 3511 1270615 SGTC_819 1013-0258 27.7 µM -0.6275004658741 0.253774144914084 no 2500 0.265165615444103 3569 5753198 SGTC_554 4483-2211 187 µM -0.627926428934185 0.253646876804911 no 2501 0.265026068368301 3508 747107 SGTC_2159 5658611 73.75 µM -0.627995073810168 0.253626370408408 no 2502 0.265003583544053 3584 793844 SGTC_1106 tegaserod maleate 11.7 µM -0.629277203356861 0.253243517823647 no 2503 0.264583796556202 3539 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.630679872418281 0.252825019660259 no 2504 0.264124931068825 3506 390807 SGTC_1834 st055981 52.8 µM -0.632848081150055 0.252178833337069 no 2505 0.26341642748012 3626 471719 YDL150W RPC53 SGTC_417 st075190 100 µM -0.63406224431323 0.251817359868787 no 2506 0.263020100700387 3591 222757 SGTC_1007 4101-0031 70 µM -0.637179706556305 0.250890501767118 no 2507 0.262003897326305 3566 1146276 SGTC_3170 9103054 49.47 µM -0.637255735371604 0.250867920086158 no 2508 0.261979139276722 3535 16432970 SGTC_2073 5212005 126 µM -0.63946466993479 0.250212303898392 no 2509 0.261260345100833 3467 691789 SGTC_2355 9061122 103.12 µM -0.639652874453872 0.250156486458321 no 2510 0.261199149641469 3550 5302957 SGTC_785 1270-0111 65.3 µM -0.640452257648172 0.249919480097411 no 2511 0.260939309076677 3574 6741994 SGTC_3266 9136860 49.47 µM -0.640963194293093 0.249768056711882 no 2512 0.260773298107542 3516 4871271 YPR165W RHO1 SGTC_1976 st070609 63.5 µM -0.641359486621336 0.249650643363627 no 2513 0.260644574224057 3543 682556 SGTC_1635 st007035 42.4 µM -0.641860695705116 0.24950218731343 no 2514 0.26048181807656 3608 3716403 SGTC_1371 2421-0008 32.7 µM -0.643916512941873 0.248893753915046 no 2515 0.259814786614245 3572 2827552 SGTC_2553 4-methylesculetin 85.09 µM -0.644270660227986 0.248789021362038 no 2516 0.259699968865393 3581 5319502 SGTC_360 0957-0399 1.01 µM -0.646595410190283 0.248102102230704 no 2517 0.25894691466605 3590 6752301 YPR165W RHO1 SGTC_659 k018-0002 107 µM -0.646782294885097 0.248046925347728 no 2518 0.258886426360397 3592 6797879 YHR007C ERG11 SGTC_2381 9035592 200 µM -0.646837590324825 0.248030600867906 no 2519 0.258868530483297 3546 4749657 SGTC_1250 0485-0349 40.2 µM -0.648056586088019 0.247670871059344 no 2520 0.258474175996038 3557 6842794 YDL195W SEC31 SGTC_2801 7907800 81.82 µM -0.6488100187135 0.247448669933397 no 2521 0.2582305904552 3598 6620925 SGTC_681 1642-0006 26.6 µM -0.652714024980012 0.246299014927431 no 2522 0.256970329546601 3611 4446530 SGTC_1591 genipin 88.4 µM -0.653587812118968 0.246042094091084 no 2523 0.256688699255807 3594 442424 A DNA cross-linking agent. SGTC_2837 9008476 45.46 µM -0.654749149015824 0.245700847254106 no 2524 0.256314637707351 3619 2992805 SGTC_505 gw-5074 63.9 µM -0.654916955896077 0.245651559960294 no 2525 0.256260611346102 3596 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2345 9052315 157.45 µM -0.65537094247286 0.245518244192415 no 2526 0.256114477596449 3586 6469265 SGTC_427 1354-0053 47.3 µM -0.655916022492399 0.245358229675941 no 2527 0.25593907921004 3656 6813657 SGTC_2504 purpurogallin 52.29 µM -0.656039685463403 0.245321934789096 no 2528 0.255899295088221 3568 5281571 An antioxidant. SGTC_1548 st061468 90.8 µM -0.656343717859837 0.245232714031475 no 2529 0.255801497300839 3594 390799 SGTC_2103 5378138 10 µM -0.656695139035273 0.245129608395365 no 2530 0.25568848032704 3650 244142 SGTC_1739 st037196 92.5 µM -0.656878136125072 0.24507592697774 no 2531 0.255629638827978 3619 612214 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.657685122810449 0.244839276310936 no 2532 0.255370241998214 3614 616764 SGTC_1799 st045822 46.1415 µM -0.658709996577254 0.244538907142444 no 2533 0.255041006215836 3611 3674992 SGTC_1508 1080-0625 72.9 µM -0.659201078376644 0.244395051662639 no 2534 0.254883327270785 3549 767111 SGTC_2425 5628681 7.85 µM -0.659978324133164 0.244167461729993 no 2535 0.254633869722168 3618 5714958 SGTC_1723 st034307 2.5525 µM -0.66159706652113 0.243693835264184 no 2536 0.254114744027988 3634 867466 SGTC_2130 NSC 7 2.4545 µM -0.66184295592902 0.243621934111032 no 2537 0.254035936647604 3601 21448 SGTC_3133 9127736 49.47 µM -0.661892016508129 0.243607589552117 no 2538 0.254020214301408 3629 27243420 SGTC_2781 5567276 71.43 µM -0.663251554902155 0.243210262942119 no 2539 0.253584728913647 3615 2853274 SGTC_1183 1254-0324 198 µM -0.66342254392191 0.243160316024278 no 2540 0.253529985734014 3632 5799357 SGTC_789 1309-1135 70.6 µM -0.663691551932684 0.243081748398809 no 2541 0.253443873745068 3623 3092424 SGTC_733 4069-0007 56.1 µM -0.663822424959633 0.243043530029876 no 2542 0.253401985619403 3655 5717425 YNL287W SEC21 SGTC_2365 9042475 200 µM -0.663827941950626 0.243041918994669 no 2543 0.25340021989306 3624 6464479 SGTC_3047 9092122 49.47 µM -0.66429857072247 0.24290451035828 no 2544 0.253249617821523 3581 17173831 SGTC_2605 digitonin 300 nM -0.66678472555329 0.242179330212491 no 2545 0.252454825355251 3672 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_543 3844-1095 191 µM -0.667628383803153 0.241933512673854 no 2546 0.25218541743789 3629 4230703 SGTC_2329 6138490 200 µM -0.668105326766224 0.241794605241762 no 2547 0.252033180927218 3610 720019 SGTC_2846 9008642 19.48 µM -0.668815493621068 0.241587852656308 no 2548 0.251806591034298 3615 2992898 SGTC_1872 amphotericin b 148 nM -0.66960218131146 0.24135893448515 no 2549 0.251555711582371 3626 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3313 9133968 57.047 µM -0.671205260599183 0.240892819589276 no 2550 0.251044888941875 3611 1494643 SGTC_2406 ethylparaben 405.7 µM -0.672117166798271 0.240627890376477 no 2551 0.250754554302182 3527 8434 A possible steroid mimic. SGTC_287 k060-0039 29.6 µM -0.673088223332151 0.240345951128879 no 2552 0.250445582832502 3663 5861974 SGTC_3202 9113761 49.47 µM -0.676997426590048 0.23921276488851 no 2553 0.249203793567364 3674 4798415 SGTC_357 1325-0123 420 µM -0.677165491993765 0.239164112214338 no 2554 0.249150479777126 3619 1098503 SGTC_1433 4060-0023 7.6 µM -0.677230614512013 0.239145261574856 no 2555 0.249129823210674 3644 3840627 SGTC_378 3970-0959 8.33 µM -0.677864569072612 0.238961796841897 no 2556 0.248928783316055 3645 6615653 SGTC_135 0933-0004 26.348 µM -0.678465739325452 0.238787890915014 no 2557 0.248738219782681 3614 21230617 YGL099W LSG1 SGTC_2620 irigenin 100 µM -0.678641653410356 0.238737015761942 no 2558 0.248682471888975 3660 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_864 0469-0573 172 µM -0.678693015452926 0.238722162744317 no 2559 0.248666196302552 3607 689425 SGTC_1727 st034309 9.9045 µM -0.679168472752774 0.23858469269193 no 2560 0.248515560493728 3670 870305 SGTC_2448 5185112 27.17 µM -0.681132245068528 0.238017362047993 no 2561 0.247893907730466 3638 5718189 SGTC_2063 5246145 200 µM -0.68139183029619 0.237942423670793 no 2562 0.247811795451836 3674 711240 SGTC_2847 9005661 71.43 µM -0.685435293318865 0.236776807919823 no 2563 0.246534639664828 3561 2991449 SGTC_703 3875-0075 71.8 µM -0.685924490505097 0.236635999489488 no 2564 0.24638036282397 3689 2850814 SGTC_862 0452-0056 10.2 µM -0.687490647949029 0.236185513393299 no 2565 0.245886796038289 3606 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_381 3461-2219 42.7 µM -0.688646363811693 0.235853388938887 no 2566 0.245522918445121 3640 2883159 SGTC_1948 st076329 66.6 µM -0.689194368517632 0.235695995826846 no 2567 0.245350480109284 3569 24208413 SGTC_1263 0774-1208 64.8 µM -0.692857593494652 0.234645365639654 no 2568 0.24419946227739 3697 906585 SGTC_168 3970-0862 530.542 µM -0.695776618403956 0.233810033052493 no 2569 0.243284367112296 3680 3135186 SGTC_2569 tetrandrine 100 µM -0.697122035023768 0.233425572950193 no 2570 0.242863212677802 3660 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_349 k015-0014 24 µM -0.698222286078594 0.233111431083549 no 2571 0.2425190956201 3652 2196908 SGTC_2112 5488546 200 µM -0.698234759623785 0.233107871003621 no 2572 0.242515195879849 3657 600757 SGTC_2025 5147754 141 µM -0.698482075795386 0.233037290621148 no 2573 0.242437881745401 3681 315777 YLR208W SEC13 SGTC_2505 galangin 7.89 µM -0.699648330081348 0.232704618851629 no 2574 0.242073476053209 3607 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2350 9023895 38.85 µM -0.700721334817802 0.232398779611232 no 2575 0.241738469464512 3682 2997209 SGTC_2113 5491891 107.031 µM -0.700757769894357 0.232388398423889 no 2576 0.24172709835985 3686 789979 SGTC_2642 cholecalciferol 100 µM -0.701489276857106 0.232180029929463 no 2577 0.241498862150906 3662 9821465 A vitamin D precursor, similar to steriods. SGTC_2418 pentamidine 31.67 µM -0.702645656373953 0.231850849429672 no 2578 0.241138301071589 3671 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1800 st050079 29.0735 µM -0.703025407259323 0.231742804463375 no 2579 0.241019957970207 3633 3645560 SGTC_2551 apiole 73.87 µM -0.70339729187439 0.23163702476493 no 2580 0.240904096877787 3556 10659 A possible DNA adduct former. SGTC_860 0443-0016 25.1 µM -0.704016065776642 0.231461078971452 no 2581 0.240711384297642 3700 5337942 SGTC_507 nimesulide 162 µM -0.704197588503679 0.231409477876354 no 2582 0.240654866300676 3716 4495 A COX2 inhibitor. SGTC_671 0560-0003 407 µM -0.704640901274218 0.231283485227353 no 2583 0.240516869048166 3628 3238678 SGTC_391 gliotoxin 8.33 µM -0.706652194624117 0.230712342209649 no 2584 0.239891322272321 3737 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2891 9063876 19.48 µM -0.706784556548993 0.230674783305834 no 2585 0.239850186584525 3670 6472478 SGTC_3056 9094900 49.47 µM -0.70708863851952 0.230588510212187 no 2586 0.239755697993875 3642 25236784 SGTC_3117 9124945 49.47 µM -0.707350207729742 0.230514313120989 no 2587 0.239674435813371 3615 17592065 SGTC_3010 9080089 71.4286 µM -0.707770706363545 0.230395061858537 no 2588 0.23954383025276 3679 17027233 SGTC_1370 2001-0092 44.6 µM -0.707844033952151 0.230374270061632 no 2589 0.23952105891231 3761 790957 SGTC_1092 toremifene 6.32 µM -0.709872037729516 0.229799652150217 no 2590 0.238891745910314 3688 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_872 0588-0139 234 µM -0.711842096237044 0.229242221837514 no 2591 0.238281280873288 3705 2047100 SGTC_1968 st069590 43.6 µM -0.714578555664966 0.228469197026594 no 2592 0.237434749711688 3662 6384066 SGTC_898 1000-0849 28.3 µM -0.714635603146528 0.228453097232596 no 2593 0.237417119504318 3653 6751807 SGTC_2600 tangeritin 87.95 µM -0.71519070910625 0.228296469934088 no 2594 0.237245604617908 3669 68077 A bioactive flavone. SGTC_725 1497-0963 19 µM -0.715597758116959 0.228181656377653 no 2595 0.237119879162249 3726 3549977 SGTC_3234 9132280 49.47 µM -0.716490203318072 0.227930044055803 no 2596 0.236844357274743 3706 17612295 SGTC_810 3825-7150 143 µM -0.71772745253696 0.227581477448652 no 2597 0.236462676449717 3737 22330411 YGL099W LSG1 SGTC_2259 7964009 200 µM -0.719843396358185 0.226986054951752 no 2598 0.235810711125669 3711 313134 SGTC_834 0312-0008 75.7 µM -0.722306239775545 0.226294123233722 no 2599 0.235053108717162 3708 6385573 YIL048W NEO1 SGTC_3261 9137475 49.47 µM -0.722347190646837 0.226282628234875 no 2600 0.235040523075518 3583 17027690 SGTC_223 busulfan 5 mM -0.72412168477894 0.225784840801886 no 2601 0.234495516399825 3694 2478 A DNA alkylator. SGTC_1818 st052136 56.3 µM -0.725321115833446 0.225448723239288 no 2602 0.234127527237915 3605 674169 SGTC_474 dl-dihydrosphingosine 5 µM -0.725776178882741 0.225321274699786 no 2603 0.233987996206757 3727 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2571 chrysanthemic acid 100 µM -0.728295775778245 0.224616355329913 no 2604 0.233216273813183 3716 2743 An insecticide. SGTC_1856 st057054 55.7 µM -0.728860179332865 0.224458621194701 no 2605 0.233043597633996 3748 1266018 SGTC_1407 3909-7909 12.3 µM -0.730659014333133 0.22395631955044 no 2606 0.232493727911787 3720 4411780 SGTC_2373 9071805 200 µM -0.731894334610944 0.223611742410051 no 2607 0.232116532193419 3698 10149009 SGTC_442 cape 100 µM -0.732357874396721 0.22348252161785 no 2608 0.231975081759524 3679 5281787 SGTC_41 0478-0632 82.643 µM -0.733408602573785 0.223189767896281 no 2609 0.231654626961813 3704 3750424 SGTC_1251 0490-5699 265 µM -0.733660024185684 0.223119749229163 no 2610 0.231577984103386 3742 3883818 SGTC_1067 clotrimazole 1.36 µM -0.734569146053898 0.222866671332644 no 2611 0.23130096720966 3752 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3346 9158254 43.5805 µM -0.735828470255158 0.222516375765875 no 2612 0.230917546325325 3728 17639500 SGTC_492 tmb-8 126 µM -0.737788552661886 0.221971781324811 no 2613 0.230321475319099 3626 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2129 girgensonine 121.053 µM -0.738591163970935 0.221749001498382 no 2614 0.230077645658458 3795 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1445 4239-0156 97.7 µM -0.738728109813997 0.22171100237148 no 2615 0.230036056564085 3810 4008346 SGTC_985 1493-0307 8.71 µM -0.739190133611438 0.221582829504152 no 2616 0.229895775561771 3714 3278274 SGTC_1675 st018485 24.5 µM -0.739211841755928 0.221576808355896 no 2617 0.229889185650205 3792 3323024 SGTC_553 k007-0256 45.7 µM -0.740548910171687 0.22120612843935 no 2618 0.229483497527145 3785 6287000 SGTC_2125 5246583 200 µM -0.740968883445344 0.221089771107237 no 2619 0.229356153707856 3755 835267 SGTC_2021 4019055 173 µM -0.744419653702756 0.220135031613384 no 2620 0.22831131625567 3734 44827708 YER133W GLC7 SGTC_1042 0350-0096 82 µM -0.746034721136414 0.219688997572687 no 2621 0.227823220490157 3750 3122515 SGTC_2703 st077852 53.4 µM -0.746410685896165 0.21958524169009 no 2622 0.227709683042535 3730 6281836 SGTC_465 cgp-37157 41 µM -0.747697701194121 0.21923027418286 no 2623 0.227321259034835 3688 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_246 cycloheximide 667 µM -0.748055014822647 0.219131783202458 no 2624 0.227213487254266 3639 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_228 caffeine 993.056 µM -0.748111346174688 0.219116258184638 no 2625 0.227196499402289 3740 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3148 9097893 49.47 µM -0.750578005771817 0.218437062964588 no 2626 0.226453330934913 3736 17174100 SGTC_1578 josamycin 24.2 µM -0.751686715576934 0.218132174908203 no 2627 0.226119740561503 3738 5282165 A P450 substrate. SGTC_1704 st028805 70.8 µM -0.752009775551979 0.218043381663065 no 2628 0.226022590038432 3782 2876101 SGTC_3354 9151612 71.43 µM -0.752502149508908 0.217908092445678 no 2629 0.225874568847029 3778 27261949 SGTC_451 chloral hydrate 100 µM -0.752889932316695 0.217801575742076 no 2630 0.225758029237844 3840 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2941 9056145 11.23 µM -0.753385705631893 0.2176654398132 no 2631 0.22560908500322 3639 2119517 SGTC_2928 9011484 9.79 µM -0.754225074151656 0.217435066979252 no 2632 0.22535704192502 3775 2994751 SGTC_3315 9136395 68.55 µM -0.754691996419813 0.217306976587735 no 2633 0.225216904938883 3783 16876844 SGTC_1961 st076550 68.7 µM -0.755273685237536 0.21714746336151 no 2634 0.225042392234576 3748 1579337 SGTC_1809 st050081 57.6 µM -0.755874436139816 0.216982793877218 no 2635 0.224862241168248 3808 5036894 SGTC_460 trequinsin 123 µM -0.755910544011492 0.216972898789294 no 2636 0.224851415872092 3805 5537 A vasodilator. SGTC_173 1273-0061 2.693 µM -0.756657301234771 0.216768314124965 no 2637 0.224627601077266 3752 2847414 YPL266W DIM1 SGTC_2978 9011784 42.97 µM -0.756658441609251 0.216768001788633 no 2638 0.224627259385905 3807 2994934 SGTC_764 1951-2361 146 µM -0.75936609204012 0.216027139548071 no 2639 0.223816795666744 3747 5438930 SGTC_3073 9114972 49.47 µM -0.759886554790881 0.215884899761697 no 2640 0.223661199541786 3695 41905075 SGTC_566 0958-0068 16.5 µM -0.76079314844896 0.215637262035574 no 2641 0.223390313709085 3731 6815365 SGTC_2754 granisetron 64.02 µM -0.761079385497849 0.215559110082331 no 2642 0.223304826242637 3739 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_974 1326-0144 138 µM -0.762339594449734 0.215215227776834 no 2643 0.222928674141277 3824 5411856 SGTC_2208 7283366 200 µM -0.762701290983069 0.215116587875199 no 2644 0.222820780244575 3749 898663 SGTC_809 3998-0021 90 µM -0.765054720982077 0.21447541459444 no 2645 0.222119480294952 3703 715485 SGTC_1185 1319-0113 81.3 µM -0.765374625603148 0.214388344992926 no 2646 0.222024249095911 3823 4672763 SGTC_1567 st069303 68.4 µM -0.765951629635974 0.214231351698069 no 2647 0.221852541895274 3853 5581319 SGTC_1283 0922-0125 16.4 µM -0.766308517688365 0.21413428182313 no 2648 0.221746375675861 3791 3360884 SGTC_887 0885-0007 9.62 µM -0.769492894235437 0.213269297866015 no 2649 0.220800380614431 3857 5719458 SGTC_522 1273-0010 11.6 µM -0.769863124507245 0.213168863227914 no 2650 0.220690545035156 3869 5705015 SGTC_466 geldanamycin 89.2 µM -0.77212011289833 0.212557193086333 no 2651 0.220021645433939 3663 5288382 HSP90 inhibitor. SGTC_2456 5770359 74.46 µM -0.772615981398129 0.212422944432982 no 2652 0.219874841776143 3770 3118787 SGTC_2536 dehydroabietamide 32.04 µM -0.774508560406614 0.211911013796927 no 2653 0.219315053941056 3813 3983547 SGTC_2580 diallyl disulphide 81.36 µM -0.775616577790508 0.211611637355476 no 2654 0.218987704571173 3810 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_902 1120-0002 2.07 µM -0.77713308564559 0.21120229200596 no 2655 0.218540127837045 3778 3280475 SGTC_203 k066-0004 30.888 µM -0.778710990995747 0.210776866796753 no 2656 0.218074990088244 3850 6795412 SGTC_765 1319-0117 244 µM -0.779889524508746 0.210459445939878 no 2657 0.21772795247931 3764 3487746 YGL099W LSG1 SGTC_2106 5357045 167.29 µM -0.780242856310869 0.210364335857828 no 2658 0.217623970521773 3835 668842 SGTC_394 menadione 8.33 µM -0.78141198333934 0.210049809436694 no 2659 0.217280112675436 3754 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1715 st032160 10.2275 µM -0.782367076890183 0.209793068917107 no 2660 0.216999438317701 3719 5289825 SGTC_2986 9022445 71.43 µM -0.782368122252315 0.209792788012427 no 2661 0.21699913123086 3722 6459286 SGTC_698 k064-0052 127 µM -0.782588566648789 0.209733556195388 no 2662 0.216934378829978 3858 5088751 SGTC_3254 9136651 49.47 µM -0.782713681694442 0.209699943060802 no 2663 0.216897633036545 3806 16454030 SGTC_2960 9079389 5.97 µM -0.783482850215782 0.20949336953489 no 2664 0.21667181035437 3781 16457355 SGTC_1619 st003326 88.7 µM -0.783972520212737 0.209361922567135 no 2665 0.21652811742191 3744 2849032 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.784332028225467 0.209265447175832 no 2666 0.216422655439086 3781 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3037 9091026 49.47 µM -0.788400390766814 0.208175510917775 no 2667 0.21523127116048 3818 25236398 YIL048W NEO1 SGTC_727 3032-0951 202 µM -0.788446727117198 0.208163116485124 no 2668 0.215217723926785 3817 3652836 SGTC_3124 9127567 49.47 µM -0.78892909232147 0.208034115290852 no 2669 0.21507672550941 3749 17592030 SGTC_803 4488-1585 147 µM -0.789004735070437 0.208013890076142 no 2670 0.215054619518423 3841 747204 SGTC_38 0929-0051 58.268 µM -0.792319093673491 0.207128843357836 no 2671 0.214087320602503 3839 1379719 SGTC_1001 4048-4355 44.4 µM -0.792402247557243 0.207106667119073 no 2672 0.214063084662323 3811 21824233 SGTC_2839 9003951 25.97 µM -0.792484408466161 0.207084757075497 no 2673 0.214039139701899 3841 2990634 SGTC_934 2950-0684 338 µM -0.793611446225939 0.206784345698924 no 2674 0.213710833420385 3874 1121253 SGTC_2710 st078562 53.7235 µM -0.794381346548223 0.206579277535802 no 2675 0.213486730060425 3792 17250908 SGTC_3105 9121040 49.47 µM -0.794533656355879 0.206538723063705 no 2676 0.213442411801371 3645 41448907 SGTC_1989 st071868 50.2 µM -0.795414920871484 0.206304167495213 no 2677 0.213186091658645 3823 16414057 SGTC_1392 3455-1037 33.9 µM -0.797854572505028 0.205655658791982 no 2678 0.212477443997389 3826 981132 SGTC_3027 9089541 49.47 µM -0.799995842874258 0.205087464161911 no 2679 0.21185660286961 3822 9943819 SGTC_459 nigericin 15.3 µM -0.801662516137056 0.204645852181078 no 2680 0.211374102060193 3860 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_645 0845-0943 5.41 µM -0.804348635712906 0.203935313248292 no 2681 0.210597828272762 3854 1885106 SGTC_1178 0988-0033 191 µM -0.805058971995213 0.203747659426957 no 2682 0.210392825019543 3896 5392207 SGTC_351 caspofungin 25 nM -0.806238052661774 0.203436401915847 no 2683 0.210052800748178 3854 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1583 clindamycin 39.6 µM -0.807046852003829 0.203223056587127 no 2684 0.209819745326038 3806 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1703 st026983 48.3 µM -0.807275443011681 0.203162782997385 no 2685 0.209753904419711 3829 1104023 SGTC_2820 7989630 71.43 µM -0.807509449973885 0.203101092414222 no 2686 0.209686516143954 3761 2984098 SGTC_3039 9090270 49.47 µM -0.80794722922719 0.202985711964265 no 2687 0.20956048062998 3800 17173750 SGTC_2797 7859098 81.82 µM -0.808413780624043 0.202862791468443 no 2688 0.209426210752035 3850 972681 SGTC_2994 9053520 71.4286 µM -0.8086737114419 0.202794327790648 no 2689 0.209351426638118 3902 4647384 SGTC_2175 5807670 165.306 µM -0.809280428973363 0.202634577019239 no 2690 0.209176930459495 3820 241186 SGTC_2055 5235184 200 µM -0.810154673186137 0.202404517887487 no 2691 0.208925642393124 3886 2836034 SGTC_1212 0520-0165 585 µM -0.810488850579002 0.202316619709575 no 2692 0.208829635234792 3929 5403258 SGTC_2860 9025725 38.96 µM -0.810758851993638 0.202245618320456 no 2693 0.208752084439096 3838 40546248 SGTC_411 enrofloxacin 100 µM -0.811212864106089 0.202126261849818 no 2694 0.208621719686605 3923 71188 A bacterial gyrase inhibitor. SGTC_1138 3761-0006 1.03 µM -0.811683474169035 0.202002586396948 no 2695 0.208486639678255 3814 12061087 SGTC_2196 6573537 42.6665 µM -0.812918056505792 0.201678355779602 no 2696 0.208132520619232 3864 2903087 SGTC_3260 9137109 49.47 µM -0.813206169786472 0.201602735279555 no 2697 0.208049931313284 3738 17478346 SGTC_237 nikkomycin 200 µM -0.814385974677932 0.201293251556407 no 2698 0.207711935407892 3853 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2966 9084041 48.03 µM -0.816611930208632 0.200710120159601 no 2699 0.207075117547436 3803 17741380 SGTC_1377 2944-0135 198 µM -0.818391533660647 0.200244649414881 no 2700 0.206566827257695 3915 1894137 SGTC_537 1334-0398 209 µM -0.821050879358186 0.199550284611293 no 2701 0.205808643837837 3824 5846986 SGTC_581 0958-0271 211 µM -0.82205054212428 0.199289644238054 no 2702 0.205524066044125 3875 4591145 SGTC_1851 st056236 18.9 µM -0.823198964082081 0.198990471308501 no 2703 0.205197428941992 3831 5393171 SGTC_1748 st037455 53.6035 µM -0.824895807836236 0.198548925886291 no 2704 0.204715373288851 3891 580690 SGTC_325 2810-4341 181 µM -0.828292413436769 0.197666853098653 no 2705 0.203752459136473 3872 774970 SGTC_393 acivicin 6.25 µM -0.830319152237158 0.197141654436533 no 2706 0.203179181201981 3738 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2004 4023728 41.89 µM -0.830320416203946 0.19714132716237 no 2707 0.203178823980389 3890 360084 YDR527W RBA50 SGTC_540 1187-0821 17.3 µM -0.831238680522899 0.196903651323224 no 2708 0.202919403711804 3829 847520 SGTC_861 0443-0273 110 µM -0.831516775979463 0.196831705665086 no 2709 0.202840877582563 3907 6149169 SGTC_557 1315-0110 16.2 µM -0.833737949723833 0.196257640625051 no 2710 0.202214334029559 3871 6833801 SGTC_773 4358-1457 44.6 µM -0.835135077525193 0.195897071870608 no 2711 0.201820829282192 3853 1186886 SGTC_2753 fluvastatin 17.09 µM -0.836285092903446 0.195600579349445 no 2712 0.201497268698999 3936 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_109 0132-0036 33.701 µM -0.838130096241836 0.195125477302535 no 2713 0.200978820813719 3702 67274 A color developer. SGTC_274 sirtinol 40.1 µM -0.838337340025052 0.19507215434455 no 2714 0.200920635127678 3944 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1540 guanosine 70.6 µM -0.839439528384796 0.19478871474783 no 2715 0.200611354993363 3770 6802 Guanosine is a purine nucleoside SGTC_2303 7774051 200 µM -0.84042803764803 0.194534722155553 no 2716 0.200334217128781 3843 2953184 SGTC_3292 9120825 59.784 µM -0.841022412799166 0.194382097466165 no 2717 0.200167689256268 3856 24824900 SGTC_49 0717-0965 32.132 µM -0.842944053026126 0.193889154394226 no 2718 0.199629867108602 3930 5889349 YGL099W LSG1 SGTC_597 k018-0003 82.8 µM -0.84682020119529 0.192897158014334 no 2719 0.198547673279615 3974 6786234 SGTC_2257 7960413 200 µM -0.848283781815137 0.192523401414996 no 2720 0.198139973754867 3888 2974689 YIL048W NEO1 SGTC_341 1486-1430 230 µM -0.849589537713255 0.192190322672186 no 2721 0.19777666533859 3884 2054753 YPL210C SRP72 SGTC_3213 9129884 49.47 µM -0.850214694647219 0.192030979382109 no 2722 0.197602866701445 3917 17190742 SGTC_3282 9108498 15.4605 µM -0.850689969403623 0.191909892962195 no 2723 0.197470798303979 3908 16459645 SGTC_925 2064-1272 59.6 µM -0.85125073730792 0.191767085450798 no 2724 0.197315041896844 3884 6815817 SGTC_281 1672-3440 14.9 µM -0.854275299712314 0.190997960183976 no 2725 0.196476234866652 3942 6833000 SGTC_1744 st037937 38.9 µM -0.855706756608114 0.190634611164286 no 2726 0.19608000099275 3985 1016152 SGTC_3216 9129716 49.47 µM -0.858600052278604 0.189901497832265 no 2727 0.195280604629691 3891 8056934 SGTC_3329 9141233 27.5565 µM -0.858894010638819 0.189827110760838 no 2728 0.195199497054752 3911 4909101 YNL103W MET4 SGTC_2344 7990960 76.95 µM -0.859241789907503 0.189739127284102 no 2729 0.195103565915946 3895 140813 SGTC_1678 st019265 80.2 µM -0.861722191162577 0.189112346703763 no 2730 0.194420205514393 3909 5367020 SGTC_1322 1348-1070 12 µM -0.862354976145865 0.188952650603605 no 2731 0.194246104288469 3855 6758089 SGTC_2697 mebhydrolin 72.4 µM -0.862606182166831 0.188889276723086 no 2732 0.19417701508355 3981 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2602 kawain 100 µM -0.862882163256508 0.188819667724761 no 2733 0.194101129247026 3877 5369129 SGTC_1064 honokiol 6.76 µM -0.864754404941548 0.188347861305951 no 2734 0.193586800745308 3915 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_587 k089-0003 57 µM -0.865467916114173 0.188168247465346 no 2735 0.193391009131826 3822 9659696 SGTC_2378 9074213 121.43 µM -0.871890954106378 0.186556123435001 no 2736 0.191633934512998 3901 657714 SGTC_2852 9023854 51.95 µM -0.875590566685452 0.185631448354983 no 2737 0.190626327747948 4030 19798528 SGTC_1236 0330-0013 258 µM -0.877138967657842 0.185245289203294 no 2738 0.190205580670181 3955 4617066 SGTC_147 4466-0538 29.23 µM -0.877790357824959 0.185082986744378 no 2739 0.190028749021374 3991 6742687 YHR072W ERG7 SGTC_1312 1218-2183 165 µM -0.878135440974148 0.184997040528026 no 2740 0.189935110913181 3932 6744073 SGTC_2166 5933061 31.504 µM -0.879123621998653 0.184751061920066 no 2741 0.189667125531015 4028 2877375 SGTC_323 4013-0906 34.3 µM -0.882713991452373 0.183859057523921 no 2742 0.188695410326015 3963 2910086 SGTC_183 3914-0051 30.55 µM -0.883563091902369 0.183648496766859 no 2743 0.188466055075625 3984 1596232 SGTC_3337 9144342 33.5465 µM -0.885855640531315 0.183080739231752 no 2744 0.187847661255453 3954 17682949 SGTC_652 0437-0092 114 µM -0.887729142161317 0.182617574130285 no 2745 0.187343233034969 3900 3091274 SGTC_149 3970-0822 46.1 µM -0.889231167039158 0.182246774079562 no 2746 0.186939427929334 3966 3114250 YBL034C STU1 SGTC_1451 4152-0210 104 µM -0.889265595463365 0.182238280365108 no 2747 0.18693017849281 3931 659563 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.889605951467736 0.182154325654659 no 2748 0.186838754713721 3989 65057 A dermal irritant. YDR527W RBA50 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.892428017814233 0.181459145623788 no 2749 0.186081779577659 3881 756377 SGTC_2959 9079155 11 µM -0.89813499402561 0.180058388348727 no 2750 0.184556792352228 4025 16189457 SGTC_2266 7929956 200 µM -0.898361788462761 0.18000286306705 no 2751 0.184496350582108 3923 2967153 SGTC_3230 9131665 49.47 µM -0.902697283665218 0.178943487037323 no 2752 0.183343289250044 3909 15943720 SGTC_225 nsc-122657 1.016 µM -0.902735945593986 0.178934057699888 no 2753 0.183333027040346 3978 275685 SGTC_2843 9000894 45.46 µM -0.903238725924838 0.178811462044915 no 2754 0.18319960441061 3892 2242070 SGTC_2044 5102272 200 µM -0.903691454757056 0.17870111597009 no 2755 0.18307951576033 3998 592666 SGTC_632 0781-2353 4.65 µM -0.905693332006165 0.17821370157799 no 2756 0.182549096411964 4041 6811515 YHR007C ERG11 SGTC_1319 1306-0155 43.7 µM -0.90788469279086 0.17768111358907 no 2757 0.181969572881081 4009 3122360 SGTC_1754 st042065 16.137 µM -0.908908022127213 0.177432748133258 no 2758 0.181699339452955 3834 1126236 YIL048W NEO1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.909104389051047 0.177385114298229 no 2759 0.181647513020659 3937 16623 A steroid. SGTC_2948 9070189 9.45 µM -0.90963648846269 0.177256080519426 no 2760 0.18150712439097 3919 6473636 YDL196W YDL196W SGTC_1698 5-fluorocytosine 1.055 µM -0.912190413197165 0.176637580681448 no 2761 0.180834244847239 4015 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1143 3454-2408 5.08 µM -0.912428157273389 0.176580074232401 no 2762 0.1807716863462 3908 X1143 SGTC_150 3970-0969 77.2 µM -0.915084929204139 0.175938249666628 no 2763 0.180073523057726 4078 6615640 SGTC_1353 1498-1206 8.11 µM -0.917219997428712 0.175423530639582 no 2764 0.179513684949929 4032 6756808 SGTC_457 grayanotoxin iii 135 µM -0.917635307820797 0.175323519250122 no 2765 0.179404913282575 3871 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2395 5646831 180.19 µM -0.921634961381687 0.174362209186899 no 2766 0.17835950791562 4035 6808628 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.923751189640004 0.173854934500949 no 2767 0.177807936765171 3795 88881 An O-methylated flavonoid and antioxidant. SGTC_2269 7935389 174.42 µM -0.924218916490627 0.173742943883762 no 2768 0.177686174347575 3948 97605 SGTC_2799 7812892 81.82 µM -0.9269244256356 0.1730960484913 no 2769 0.176982887134964 4041 20205235 SGTC_249 wiskostatin 11.211 µM -0.928855075316917 0.172635363596093 no 2770 0.176482098764107 3963 2775510 A n-wasp and actin depolymerizer. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.929234359872534 0.172544951991988 no 2771 0.176383822144447 3974 688761 SGTC_2898 9056270 58.44 µM -0.929867666301907 0.172394055472571 no 2772 0.176219802973468 3944 19154699 SGTC_2629 bisabolol 100 µM -0.930230304472168 0.172307688391894 no 2773 0.176125927282604 4043 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1483 3453-0561 55.9 µM -0.932808851828287 0.171694369411306 no 2774 0.175459335027702 4020 4546991 SGTC_1063 disulfiram 1.84 µM -0.932862569470163 0.17168160727711 no 2775 0.175445465256901 4000 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2585 alliin 100 µM -0.933301693603898 0.171577303734181 no 2776 0.17533211048538 4075 87310 A garlic compound which reacts with lipids. SGTC_2346 9031566 143.75 µM -0.934192063657984 0.171365941711616 no 2777 0.175102414412387 3982 4771086 SGTC_384 k007-0144 5.16 µM -0.934287943831302 0.171343190962776 no 2778 0.175077690806488 3983 6824886 SGTC_3240 9133527 49.47 µM -0.936942157285108 0.170714157495556 no 2779 0.174394156185312 3951 17617455 SGTC_2598 perillyl alcohol 100 µM -0.937100903081234 0.170676582550855 no 2780 0.174353328478111 4057 10819 An apoptosis inducer. SGTC_2217 6934799 96.0675 µM -0.938685791031879 0.170301731733021 no 2781 0.173946045395156 3963 675606 SGTC_1414 3917-0015 5.4 µM -0.939884349251259 0.170018604447564 no 2782 0.173638443048102 3966 6618702 SGTC_3175 9106517 49.47 µM -0.940904870391877 0.169777771607969 no 2783 0.173376805759837 4042 41468073 SGTC_1029 k015-0030 64.7 µM -0.942507849105027 0.169399926504238 no 2784 0.17296634723264 4084 2208316 SGTC_1314 1222-0010 41.1 µM -0.94401452260315 0.169045274331938 no 2785 0.17258111354066 4029 3526027 SGTC_903 1134-0042 114 µM -0.944859823593902 0.168846509979935 no 2786 0.17236522258558 4047 701009 SGTC_77 0828-0286 12.516 µM -0.946350542538132 0.168496347904118 no 2787 0.171984911078891 3947 745345 SGTC_2663 amphotericin b 100 µM -0.949755550593665 0.167698281945988 no 2788 0.171118238105128 4005 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1302 1159-0335 255 µM -0.950539961454147 0.167514777236297 no 2789 0.170918979396256 4032 649284 SGTC_3155 9099265 49.47 µM -0.950976182572496 0.167412783866844 no 2790 0.17080823328702 4065 25236499 SGTC_2076 5212012 200 µM -0.951737918678694 0.167234777424748 no 2791 0.170614956841553 3970 604802 SGTC_2785 7756463 72.73 µM -0.955966649129194 0.166248805391987 no 2792 0.169544542158163 3995 2201551 SGTC_1355 1499-0035 1.68 µM -0.957291822151678 0.165940601864963 no 2793 0.169209990926676 4024 1548538 SGTC_1490 4089-0339 670 nM -0.957436354912429 0.165907009351754 no 2794 0.16917352804993 3970 742542 SGTC_1072 oxiconazole 14.9 nM -0.959156069082271 0.165507648200016 no 2795 0.168740063933045 4038 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_600 1495-0418 41.6 µM -0.959379526010546 0.165455801531861 no 2796 0.168683792736715 4025 5377768 SGTC_1795 st049545 62.3 µM -0.959589419551579 0.165407111422855 no 2797 0.168630948075231 3957 5291882 SGTC_3137 9097352 49.47 µM -0.960996228868069 0.165081005779968 no 2798 0.168277031992957 4058 44120435 SGTC_1959 st077091 55.8 µM -0.961201804244578 0.165033387227834 no 2799 0.168225354695248 4033 821356 YKL052C ASK1 SGTC_1804 st050076 49.1 µM -0.962792197272815 0.164665296336458 no 2800 0.167825908611631 4084 3895976 SGTC_1350 1495-0454 146 µM -0.962917377702174 0.164636346364517 no 2801 0.167794494006156 4105 1069057 SGTC_779 1360-0071 233 µM -0.964050148169547 0.164374525078628 no 2802 0.16751039220339 4108 7566 SGTC_2861 9024595 19.48 µM -0.965240870627016 0.1640996003093 no 2803 0.167212090174711 3943 16482810 SGTC_2721 ifenprodil 61.44 µM -0.965387130139199 0.16406585117091 no 2804 0.167175472595492 4030 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1265 0819-1001 68.8 µM -0.965440907292583 0.164053443314695 no 2805 0.167162010229723 4004 3106768 SGTC_3297 9117502 71.43 µM -0.966553957814857 0.163796768889761 no 2806 0.166883530384805 4068 7453720 SGTC_2490 carminic acid 95.39 µM -0.966560630387225 0.163795230951133 no 2807 0.166881861842434 4013 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_664 1222-0054 14.9 µM -0.967157043312786 0.163657803612559 no 2808 0.166732766390786 4019 6813991 SGTC_2493 resveratrol 26.09 µM -0.968600285959747 0.163325556957812 no 2809 0.166372330320151 3924 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2328 6201408 200 µM -0.971818269649152 0.162586328843199 no 2810 0.165570482628565 4060 2890418 SGTC_2983 9022671 12.99 µM -0.973100876858872 0.162292298817183 no 2811 0.165251584144572 4074 6405161 SGTC_458 nppb 133 µM -0.973369661853181 0.162230725364971 no 2812 0.16518480573594 4078 4549 A chloride channel blocker. SGTC_1035 k081-0041 55.2 µM -0.974599200920109 0.161949255654737 no 2813 0.164879555079629 4091 731709 SGTC_1016 4226-1401 38 µM -0.977392230130106 0.161311050029435 no 2814 0.164187504076258 4024 2901613 SGTC_2520 obtusaquinone 4.71 µM -0.977923143830756 0.161189922344077 no 2815 0.164056168765699 4114 5967872 SGTC_3299 9121982 43.1275 µM -0.979980071222326 0.160721195884001 no 2816 0.163547977987188 4133 17594604 YPL160W CDC60 SGTC_2634 4'-methoxyflavone 100 µM -0.981790719153052 0.16030932819367 no 2817 0.163101480659465 4078 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2523 spermine 47.74 µM -0.981931805869414 0.160277264223328 no 2818 0.163066722636976 4080 1103 A DNA binding polyamine. SGTC_975 1335-0046 28.5 µM -0.982050973301471 0.160250184988861 no 2819 0.163037368384669 4084 16486740 SGTC_1424 4048-1941 275 µM -0.982112282239898 0.160236254502563 no 2820 0.16302226762651 4132 X1424 SGTC_362 0310-0100 9.03 µM -0.982329699581452 0.160186859778596 no 2821 0.162968723764499 4157 790235 SGTC_992 3909-8734 162 µM -0.983799128179173 0.159853283469093 no 2822 0.162607144046251 4085 4288319 SGTC_2206 7254556 146.969 µM -0.984992904262987 0.159582618054182 no 2823 0.162313778201086 4063 4398905 SGTC_3248 9135562 49.47 µM -0.985774446688062 0.15940558113061 no 2824 0.162121903913156 4058 17650701 SGTC_910 3454-3003 490 µM -0.985942388585086 0.159367555307421 no 2825 0.162080692257299 4018 820824 SGTC_2141 5621638 7.665 µM -0.988738125397315 0.158735410083255 no 2826 0.161395642115094 4104 2856238 SGTC_835 0312-0010 67.2 µM -0.989955947257747 0.158460562556648 no 2827 0.161097825810734 4041 1626196 SGTC_2693 st077581 40.7 µM -0.990117493218839 0.158424127069565 no 2828 0.161058346971845 4134 25238761 SGTC_2594 a-mangostin 100 µM -0.990470963233766 0.158344423712181 no 2829 0.160971987473582 4114 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_101 0490-5701 117.494 µM -0.990854599130316 0.158257948077799 no 2830 0.160878292081528 3878 4661669 SGTC_700 3453-2283 142 µM -0.995361536414522 0.157244357160634 no 2831 0.159780229358288 4140 565664 SGTC_462 ag-879 158 µM -0.995413840894868 0.15723261921701 no 2832 0.15976751483158 4102 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_908 3448-7491 47.7 µM -0.99610370711061 0.157077856357686 no 2833 0.159599879430866 4090 1203031 SGTC_3029 9088683 49.47 µM -0.9988750616701 0.156457147630764 no 2834 0.158927609179462 4130 25236615 SGTC_2143 5623677 140.463 µM -0.999315493345485 0.156358651750294 no 2835 0.158820941190198 4036 5375313 SGTC_3119 9125183 49.47 µM -0.999432992116543 0.156332381830363 no 2836 0.158792492136368 3899 22695334 SGTC_2445 5742597 35.57 µM -1.00024950924595 0.156149908392865 no 2837 0.158594887530368 4062 1774255 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.0016511913626 0.155836990945308 no 2838 0.158256043819453 4147 23847180 SGTC_2246 7293507 91.5585 µM -1.00303929966286 0.155527511496341 no 2839 0.157920949971506 4131 887656 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.00387873624655 0.155340555551226 no 2840 0.15771853348286 4124 4174840 SGTC_979 1426-2828 121 µM -1.00580358343067 0.154912421487854 no 2841 0.157255031599317 4192 747872 SGTC_605 1315-0399 119 µM -1.00594468008007 0.154881068758709 no 2842 0.15722109088878 4173 24020461 SGTC_3226 9131256 49.47 µM -1.00862530487772 0.154286210182758 no 2843 0.15657718336259 4038 17178073 SGTC_2491 paeonol 100 µM -1.00929623827835 0.154137559782308 no 2844 0.156416291830215 3990 11092 Increases levels of cortical cytochrome oxidase. SGTC_106 0092-0003 11.579 µM -1.00993732148746 0.153995611456919 no 2845 0.156262660202994 3999 1072148 SGTC_1676 st018489 23.4 µM -1.01131744182185 0.153690319520976 no 2846 0.155932260352415 4127 3696235 SGTC_2744 captopril 92.04 µM -1.01234706804341 0.153462820403043 no 2847 0.155686068693109 4131 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2226 7298446 200 µM -1.01648548728103 0.15255067475486 no 2848 0.154699127493725 4089 3283010 SGTC_3034 9090421 49.47 µM -1.01748236203851 0.152331493127025 no 2849 0.154462009362865 3992 17173761 SGTC_314 1671-0008 2.74 µM -1.01961218839273 0.151863911551862 no 2850 0.153956211084984 3982 3913060 SGTC_269 exalamide 29 µM -1.01968561758785 0.151847807946427 no 2851 0.153938792440854 4023 3316 A derivative of salicylamide. SGTC_2172 5754775 163.918 µM -1.01971164303321 0.151842100631981 no 2852 0.153932619079092 4078 2263357 SGTC_3286 9117135 37.221 µM -1.02142512314673 0.151466652365627 no 2853 0.153526533755122 4087 3438150 SGTC_247 mechlorethamine 29.705 µM -1.02147442092819 0.151455859651695 no 2854 0.153514860962376 4017 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2471 5466956 24.79 µM -1.02194677195679 0.151352474236436 no 2855 0.153403046869223 4089 724419 SGTC_2027 5150920 200 µM -1.02446774778743 0.150801491708692 no 2856 0.152807198470094 4059 786715 SGTC_2268 7933382 153.85 µM -1.02736500037079 0.150169921630156 no 2857 0.152124312791883 4132 935025 YOR257W CDC31 SGTC_3327 9140648 26.9345 µM -1.02847466045341 0.149928495224942 no 2858 0.151863302224032 4155 8029710 SGTC_3033 9090887 49.47 µM -1.02916733474231 0.149777922825892 no 2859 0.151700524594639 4145 19325384 SGTC_372 0155-0182 15.9 µM -1.03287253242112 0.14897420641752 no 2860 0.15083177724854 4031 771486 SGTC_217 ketoconazole 989 nM -1.03375647639783 0.148782891367342 no 2861 0.15062501166139 3971 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2681 menadione 3.18 µM -1.03443678976408 0.148635760661702 no 2862 0.150466006435393 4146 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_399 oxolinic acid 75 µM -1.03541855631525 0.14842360649267 no 2863 0.150236741701832 4103 4628 A DNA gyrase inhibitor. SGTC_2749 bexarotene 57.39 µM -1.03593552697139 0.148311973511327 no 2864 0.150116110965302 4170 82146 An retinoic acid receptor inhibitor. SGTC_252 miconazole 1.30953 nM -1.03653921173162 0.148181686868922 no 2865 0.149975327969689 4027 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1293 1000-1278 195 µM -1.03725292334744 0.148027753156584 no 2866 0.149808999640384 4183 678847 SGTC_2439 5492030 7.2 µM -1.03792068865948 0.147883826114933 no 2867 0.149653490414433 4132 5722370 SGTC_1967 st070177 51.4 µM -1.03962834273305 0.147516192521547 no 2868 0.149256301886278 4169 5729214 SGTC_2358 9037157 4 µM -1.03968729872836 0.147503511079474 no 2869 0.149242601711391 4134 2388925 SGTC_489 paxilline 115 µM -1.04057074291332 0.147313569597468 no 2870 0.149037407809634 4127 105008 A toxic potassium channel blocker. SGTC_1790 st045711 43.5 µM -1.04195165068557 0.147017001398466 no 2871 0.148717047797485 4131 585119 SGTC_2486 5283202 22.39 µM -1.04204532308605 0.146996898522795 no 2872 0.148695333202003 4185 1377751 SGTC_133 0724-0033 378.92 µM -1.04618559307112 0.146110203394448 no 2873 0.147737676596076 3973 280309 SGTC_2816 7982706 58.44 µM -1.04890532143707 0.145529695810143 no 2874 0.147110848055559 4172 2981853 SGTC_263 alizarin 107.927 µM -1.04999753865772 0.14529700654729 no 2875 0.146859622195259 4161 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_438 sphingosine 6.67 µM -1.05064674333566 0.145158816688559 no 2876 0.146710432113414 4083 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3305 9127027 53.8275 µM -1.05087885401274 0.145109431027036 no 2877 0.146657116749042 4077 41905295 SGTC_3106 9121286 49.47 µM -1.05155360538357 0.144965929933617 no 2878 0.146502201533385 4137 15943471 SGTC_2555 cholic acid 100 µM -1.05419342138706 0.144405431768456 no 2879 0.145897185669622 4109 6708657 Influences liver metabolism. SGTC_2902 5787006 60.46 µM -1.05874018964502 0.14344346861026 no 2880 0.144859059613351 4115 591003 SGTC_2935 9038016 29.96 µM -1.06588318940128 0.141940974162963 no 2881 0.143238224531279 4145 6463195 SGTC_169 k015-0017 16.025 µM -1.06729722915098 0.141644806001418 no 2882 0.142918819464659 4119 1840002 SGTC_513 4245-1575 41.7 µM -1.06897232456505 0.141294502239176 no 2883 0.142541070092626 4053 719745 SGTC_2168 5727979 200 µM -1.06921826732024 0.14124311902841 no 2884 0.142485664646323 4062 695210 SGTC_2211 7117706 200 µM -1.07096638941481 0.140878260356917 no 2885 0.142092271261043 4090 822771 SGTC_40 0327-0103 19.753 µM -1.07150743960542 0.140765464948772 no 2886 0.141970663687087 4018 409036 SGTC_4 0960-0234 25.671 µM -1.07354644186633 0.140340934798373 no 2887 0.141513006523385 4182 6821112 SGTC_1783 st039459 87.517 µM -1.07455756029261 0.140130737847557 no 2888 0.14128643062687 4270 729761 SGTC_3345 9148410 3.559 µM -1.0749996698173 0.140038896885772 no 2889 0.141187438078614 4126 4903596 SGTC_1731 st035964 63 µM -1.07724996824522 0.139572068449755 no 2890 0.140684303690246 4102 6739575 SGTC_1410 3909-8106 77.9 µM -1.0773719010393 0.139546803534887 no 2891 0.140657076065687 4224 1039210 SGTC_2488 5268135 45.7 µM -1.07960905785306 0.139083808591437 no 2892 0.140158153101849 4225 1270356 YLR208W SEC13 SGTC_2544 sphondin 68.51 µM -1.08406812403737 0.138164096307096 no 2893 0.139167297427948 4163 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2126 5251174 33.877 µM -1.08608802423901 0.137748846097272 no 2894 0.138720025089435 4198 790722 SGTC_2896 9052656 71.43 µM -1.08812735166951 0.13733046682107 no 2895 0.138269445253674 3993 6469436 SGTC_1878 temozolomide 1 mM -1.08949385045897 0.137050608098282 no 2896 0.137968082609276 4102 5394 DNA alkylating agent. SGTC_536 3852-0578 10.6 µM -1.09233754472524 0.136469469899875 no 2897 0.13734238181961 4238 2869208 SGTC_1224 0823-0416 294 µM -1.09266029295398 0.136403619640847 no 2898 0.137271489856949 4256 3598164 SGTC_1492 4158-0558 28.5 µM -1.09385797479251 0.136159446858352 no 2899 0.137008636347742 4186 3967268 SGTC_423 5-fluorouracil 457 µM -1.09558277640913 0.135808335433611 no 2900 0.13663070125861 4119 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3096 9117468 49.47 µM -1.09910781982888 0.135092685426121 no 2901 0.135860519718311 4092 41316311 SGTC_3203 9113543 49.47 µM -1.10014238966347 0.13488314008191 no 2902 0.13563504347749 4270 17018012 SGTC_444 curcumin 90.4 µM -1.10084973044013 0.134740001244777 no 2903 0.135481031829532 4129 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1272 0839-0021 27 µM -1.10372540523549 0.134159147644945 no 2904 0.134856135828898 4217 5027250 SGTC_747 3448-8087 38.7 µM -1.10405370991295 0.134092943396969 no 2905 0.134784919832475 4247 5168703 SGTC_734 2023-0417 80 µM -1.10557755079973 0.133785947297511 no 2906 0.134454705470474 4186 3935732 SGTC_2294 7971431 200 µM -1.10732463450835 0.133434571151141 no 2907 0.134076798630661 4196 5741572 SGTC_917 harmaline 728.087 nM -1.11181607927137 0.132534160423273 no 2908 0.13310861848087 4161 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_250 brefeldin a 552.239 µM -1.11730530208647 0.13143941881142 no 2909 0.131931904624434 4080 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3017 9080681 49.47 µM -1.11775339598883 0.131350329740434 no 2910 0.131836165373514 4236 16451914 SGTC_2100 5377183 190 µM -1.11867580171762 0.131167070283736 no 2911 0.131639236087352 4226 2844202 SGTC_608 k048-0125 159 µM -1.1202451411134 0.130855686922668 no 2912 0.131304656205086 4247 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_402 epigallocatechin gallate 10 µM -1.12033758972948 0.130837359508056 no 2913 0.131284964685139 4151 65064 An antioxidant. SGTC_1955 wogonin 32.4 µM -1.1215429070968 0.13059857450519 no 2914 0.131028419156434 4280 5281703 A flavanone. SGTC_2964 9083345 53.42 µM -1.12327349083913 0.130256256352052 no 2915 0.130660679412445 4210 17741579 SGTC_1186 1319-0216 26 µM -1.12369924129405 0.130172136009347 no 2916 0.130570319199389 4290 4565136 SGTC_1374 2889-5571 141 µM -1.12707693697753 0.129506098516942 no 2917 0.129854976717669 4265 2853281 SGTC_1284 0929-0043 16 µM -1.12858809333471 0.129208883968945 no 2918 0.129535817900694 4227 1239883 SGTC_3342 9147791 14.508 µM -1.128589728309 0.129208562658134 no 2919 0.129535472885878 4156 1838168 SGTC_3101 9120531 49.47 µM -1.12939817131497 0.129049752482607 no 2920 0.129364951965749 4242 24824904 SGTC_431 k089-0097 107 µM -1.13554338863268 0.12784701320105 no 2921 0.128073856592139 4026 5499420 SGTC_780 0109-0199 192 µM -1.13589863073963 0.127777724328792 no 2922 0.127999495718554 4305 610414 SGTC_1620 st003704 16.5 µM -1.13684128447619 0.127593989167728 no 2923 0.127802320620016 4214 2834414 SGTC_2576 guaiol 23.12 µM -1.13687174584835 0.127588054925465 no 2924 0.127795952530579 4144 227829 SGTC_1131 3454-3128 32.3 µM -1.13796992882844 0.127374243799467 no 2925 0.127566519620106 4268 710982 SGTC_3178 9107506 49.47 µM -1.13937098720186 0.127101826197491 no 2926 0.127274225809796 4229 8897194 SGTC_548 1436-0017 110 µM -1.14245079214223 0.12650442399759 no 2927 0.126633344484492 4298 9677137 SGTC_415 dibenzyl ketone 100 µM -1.14338805051763 0.126323009043092 no 2928 0.126438755790783 4210 7593 SGTC_946 3434-1334 87.4 µM -1.14434675646833 0.126137630357834 no 2929 0.126239929890803 4219 4047976 SGTC_1607 st000305 50.6 µM -1.14562271786749 0.125891200341494 no 2930 0.125975646579732 4256 5457690 SGTC_2015 5119600 184 µM -1.14964664036131 0.125116248689462 no 2931 0.125144719988597 4276 2828786 SGTC_1036 k216-0215 33.5 µM -1.15041173514364 0.124969279800298 no 2932 0.124987164511317 4212 622330 SGTC_2142 5622915 118.518 µM -1.15683313982619 0.123740529782594 no 2933 0.123670269682743 4260 5322196 SGTC_3207 9114163 49.47 µM -1.15882563674913 0.123360986355903 no 2934 0.123263632663345 4274 849233 SGTC_2426 5582046 32.21 µM -1.16095340506191 0.122956576937107 no 2935 0.122830424373801 4264 2251934 SGTC_617 3770-0098 35 µM -1.16319059384726 0.122532374170267 no 2936 0.12237609100366 4168 5962639 SGTC_894 0960-0238 55.9 µM -1.16349158701573 0.122475380057146 no 2937 0.122315054763414 4252 6741907 YDL195W SEC31 SGTC_939 1165-0479 45.3 µM -1.16503498907143 0.122183423720622 no 2938 0.122002415070665 4252 1377347 SGTC_328 k915-0120 63.5 µM -1.17115264539774 0.12103099066613 no 2939 0.12076871292644 4251 6624543 SGTC_585 0kpi-0023 191 µM -1.17257967207985 0.120763273529079 no 2940 0.12048220257482 4187 64601 SGTC_1135 dihydrocapsaicin 536.708 nM -1.17665445895749 0.120001119041724 no 2941 0.119666725892504 4166 107982 A Capsaicinoid. SGTC_2991 9074669 71.4286 µM -1.17734884873502 0.119871578149002 no 2942 0.119528148567946 4255 17333109 SGTC_3190 9110366 49.47 µM -1.17857165748306 0.119643698543953 no 2943 0.119284391512205 4274 17123768 SGTC_2324 6149169 200 µM -1.1821869289396 0.118971753133722 no 2944 0.118565768953657 4169 2888231 SGTC_2032 5185112 25.99 µM -1.18228062798982 0.118954373441646 no 2945 0.118547184764642 4153 5718189 SGTC_2700 st077718 96.8 µM -1.18237693139482 0.118936512551344 no 2946 0.118528086175379 4273 904970 SGTC_1507 4075-3230 155 µM -1.18240599567931 0.118931122522122 no 2947 0.118522322664804 4207 659771 SGTC_2140 5586273 200 µM -1.18394858969102 0.118645292912865 no 2948 0.118216707110061 4237 854421 SGTC_817 1391-0715 46 µM -1.18460337475482 0.118524113639095 no 2949 0.118087151046868 4252 1353946 SGTC_478 N-arachidonylglycine 10 µM -1.18501198692325 0.1184485372447 no 2950 0.118006353766024 4251 5283389 SGTC_161 4065-0411 162.148 µM -1.18618288329652 0.118232158389981 no 2951 0.117775042166703 4262 1906281 YLR208W SEC13 SGTC_61 0978-8327 98.565 µM -1.18622858666643 0.118223718187657 no 2952 0.117766019937181 4188 6150059 YHR072W ERG7 SGTC_1971 st069429 63.5 µM -1.18629307764601 0.11821180913602 no 2953 0.117753289707581 4269 1246522 YGL099W LSG1 SGTC_3111 9122088 49.47 µM -1.18671878927414 0.118133217535382 no 2954 0.117669280576811 4122 16876704 SGTC_1081 sertraline 6 µM -1.18785467617507 0.117923699705128 no 2955 0.117445334424554 4267 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2689 tacrolimus 100 µM -1.19065088956218 0.117409050085606 no 2956 0.116895332415994 4297 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_569 4130-2812 160 µM -1.19194338429811 0.117171701676605 no 2957 0.116641722684473 4118 743552 SGTC_806 3966-4455 5.86 µM -1.19225967224082 0.1171136716655 no 2958 0.11657972100633 4258 714982 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.19313500458715 0.116953178770654 no 2959 0.116408252151028 4358 4213774 SGTC_692 k241-0027 77.8 µM -1.19377886740011 0.116835225539318 no 2960 0.116282240115161 4336 3600480 SGTC_1710 st031758 61.5 µM -1.19382459100821 0.116826852355295 no 2961 0.116273295113205 4317 5394341 SGTC_3328 9140624 29.0385 µM -1.19391423210895 0.116810437968516 no 2962 0.116255759860245 4286 4904392 SGTC_658 3253-0951 102 µM -1.19654825317925 0.116328845989872 no 2963 0.115741340087514 4274 1184878 SGTC_2154 5570129 200 µM -1.19900222226427 0.115881442985521 no 2964 0.115263540752458 4328 673366 SGTC_967 1306-0166 352 µM -1.20060416489338 0.115590039766718 no 2965 0.11495239234988 4296 4437607 SGTC_1765 st044815 90.4 µM -1.20126207780669 0.11547051229351 no 2966 0.114824777867114 4307 645695 SGTC_1693 xanthone 101.9 µM -1.20740951542209 0.114357908799172 no 2967 0.113637236409927 4331 7020 An insecticide. SGTC_3173 9105693 49.47 µM -1.20879879785686 0.11410752830093 no 2968 0.113370076782322 4291 17096658 SGTC_1695 st026914 34.495 µM -1.21105745248421 0.113701300939685 no 2969 0.112936693225362 4289 3289191 SGTC_2840 9008771 71.43 µM -1.21566761219982 0.112875348539737 no 2970 0.11205578332725 4244 2992978 SGTC_2065 5221596 34.26 µM -1.21734313952205 0.112576226257557 no 2971 0.111736843622327 4269 788581 SGTC_1296 1068-0102 11.9 µM -1.22217825839489 0.111716215688522 no 2972 0.11082011191392 4292 767053 SGTC_772 k072-0172 35.3 µM -1.22273634635107 0.111617253327537 no 2973 0.110714647127133 4357 5861980 SGTC_3255 9139072 49.47 µM -1.22455824305365 0.111294624038962 no 2974 0.110370854527898 4312 17646060 SGTC_3095 9117207 49.47 µM -1.22754580004578 0.11076702052807 no 2975 0.109808759374824 4283 17015229 SGTC_546 peri-Naphthalide 147 µM -1.22858567354062 0.110583799672367 no 2976 0.109613594813304 4249 223824 A penicillin ester. SGTC_73 0327-0325 16.231 µM -1.22898060851852 0.110514270922125 no 2977 0.109539538291877 4150 53298 SGTC_2685 mycophenolic acid 18.85 µM -1.22911390549862 0.110490810912806 no 2978 0.109514551122726 4298 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2301 7769476 200 µM -1.23153621282514 0.110065111322866 no 2979 0.109061190664582 4319 977820 SGTC_1587 estradiol valerate 56.1 µM -1.2318350795193 0.110012669740482 no 2980 0.10900534821428 4364 13791 A steroid. SGTC_1830 st055982 50.3 µM -1.23333431453355 0.109749872292358 no 2981 0.108725530249977 4284 455313 An antimicrobial agent. SGTC_1674 st016616 23.6 µM -1.23336313784978 0.109744824338598 no 2982 0.108720155717563 4258 625830 SGTC_2560 caryophyllene 100 µM -1.2346252997774 0.109523939806742 no 2983 0.108484994342552 4352 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1658 st012944 20 µM -1.23635183768068 0.109222304521919 no 2984 0.108163905131404 4163 24207260 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.2418586269399 0.108264228325597 no 2985 0.107144363651581 4365 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3062 9077494 49.47 µM -1.2440742392733 0.10788046539228 no 2986 0.10673612052553 4282 16459633 SGTC_1457 k015-0032 57.3 µM -1.24721154243969 0.107338735024395 no 2987 0.106159970877297 4317 4302660 SGTC_694 1315-0438 43.2 µM -1.24803662282194 0.107196591426955 no 2988 0.106008822895106 4332 6793154 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.25131254210291 0.106633560366103 no 2989 0.105410235677074 4318 688669 SGTC_1486 3970-0793 4.53 µM -1.25141944780623 0.10661522255465 no 2990 0.105390742778785 4361 2844330 SGTC_875 0709-0210 25.7 µM -1.25237267547777 0.106451813578048 no 2991 0.105217049081305 4330 6251364 SGTC_2354 9060492 162 µM -1.25286212942312 0.106367978247649 no 2992 0.105127943081823 4356 6471895 SGTC_1207 2099-0101 141 µM -1.25295378695108 0.106352284137247 no 2993 0.105111262731484 4336 5837381 SGTC_117 lucigenin 22.078 µM -1.25445929417729 0.106094742107093 no 2994 0.104837556160524 4320 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2761 levamisole 97.89 µM -1.25454005659522 0.106080939098342 no 2995 0.104822887863762 4338 26879 An alkaline phosphatase inhibitor. SGTC_1570 verbenone 133 µM -1.26010506693509 0.105132952356202 no 2996 0.103815731330392 4360 29025 A natural terpanoid with antifungal properties. SGTC_2667 digitoxin 100 µM -1.2607228536635 0.105028093087149 no 2997 0.103704358534153 4268 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2462 5162487 171.77 µM -1.26175645570143 0.104852825235751 no 2998 0.103518217643327 4292 2259986 SGTC_2085 5307070 144.047 µM -1.26290383435669 0.104658512420791 no 2999 0.103311870896427 4266 2840351 SGTC_2248 tofa 1.1 µM -1.26464500688203 0.104364136849505 no 3000 0.102999305823921 4336 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_114 0364-0001 490.298 µM -1.26541122591864 0.104234784459149 no 3001 0.102861976551392 4375 4003655 SGTC_3068 9116768 49.47 µM -1.26694805793499 0.10397568827154 no 3002 0.102586931604458 4307 41904888 SGTC_3287 9117173 37.0625 µM -1.2716767413673 0.103181404301654 no 3003 0.10174399887919 4343 2789709 SGTC_3339 9145883 14.936 µM -1.27319525267319 0.102927274773093 no 3004 0.101474382380818 4249 2030670 SGTC_80 0159-0065 512.242 µM -1.27327241797394 0.102914372973056 no 3005 0.101460695344221 4273 1548079 SGTC_3059 1327-0034 3 µM -1.27541970447288 0.102555824427165 no 3006 0.101080363983256 4191 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2275 7947463 200 µM -1.27610235706864 0.102442027263542 no 3007 0.100959669253788 4308 1225414 SGTC_2886 9058944 51.95 µM -1.27985993429825 0.101817288107454 no 3008 0.10029720035612 4251 4949929 SGTC_2375 9072683 200 µM -1.28041475099578 0.101725279119029 no 3009 0.100199654415639 4410 16798029 SGTC_2783 7738165 71.43 µM -1.28868076317537 0.100361633178259 no 3010 0.0987545464479284 4340 17201110 SGTC_567 1080-0542 68.4 µM -1.29061989593608 0.100043674756376 no 3011 0.0984177567458965 4244 5950415 SGTC_2163 5671233 125 µM -1.29093355332178 0.0999923137307766 no 3012 0.0983633596670384 4329 701023 SGTC_2967 9089538 49.85 µM -1.29145320069093 0.099907264469579 no 3013 0.0982732865500782 4355 728216 SGTC_2798 7813637 45.45 µM -1.29637285325816 0.0991046950177587 no 3014 0.0974235300171571 4356 956368 SGTC_2316 5844804 197.44 µM -1.29918130672387 0.0986486563760174 no 3015 0.0969408575703039 4367 776813 SGTC_822 1487-0950 154 µM -1.30246783477371 0.0981169403956367 no 3016 0.0963782533041806 4372 1958375 SGTC_1571 st070080 73.4 µM -1.30360019039465 0.097934227728886 no 3017 0.0961849678666439 4372 4315245 SGTC_2223 6903751 107.57 µM -1.30364869813755 0.097926406274503 no 3018 0.0961766942928626 4334 5598863 SGTC_2385 9074692 200 µM -1.30373207465606 0.0979129636010735 no 3019 0.0961624746562085 4385 17046906 SGTC_724 3910-0327 137 µM -1.30579507705698 0.0975807793679155 no 3020 0.0958111273278116 4405 2885483 SGTC_1011 4112-3381 17.4 µM -1.30961845440667 0.0969673264193791 no 3021 0.0951624711262524 4425 2877139 SGTC_33 0986-0033 35.816 µM -1.30996588332741 0.0969117228078794 no 3022 0.0951036886488559 4331 2848082 SGTC_2476 5806916 10.51 µM -1.31556243410227 0.0960192566884993 no 3023 0.0941604745504795 4275 2870194 SGTC_1909 st060837 51.5 µM -1.32092049505072 0.0951704986250302 no 3024 0.0932639376120741 4334 678937 SGTC_2611 pyromycin 23.93 µM -1.32146386026803 0.0950847349276007 no 3025 0.0931733725259068 4345 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.32576323741412 0.0944081360192381 no 3026 0.0924590667887058 4337 6708739 YPR165W RHO1 SGTC_3293 9120939 62.045 µM -1.32722371374951 0.0941791085785978 no 3027 0.0922173451084957 4371 934087 SGTC_966 1300-0360 30.2 µM -1.32773167268412 0.0940995481521325 no 3028 0.0921333831711812 4385 70588 SGTC_2834 9001755 58.44 µM -1.32814981883255 0.0940340921135771 no 3029 0.0920643091176254 4271 2989575 SGTC_918 glabranin 770.725 nM -1.33005809999212 0.0937357988234033 no 3030 0.0917495646439168 4396 124049 Also referred to as licorice root. SGTC_1306 1185-0270 9.02 µM -1.33065067913052 0.0936433120115163 no 3031 0.0916519893321544 4407 1548076 SGTC_2910 7948405 25.97 µM -1.33174493465771 0.0934727031611705 no 3032 0.091472009062482 4338 2971328 SGTC_1406 3909-7906 11.9 µM -1.332871607053 0.093297280089648 no 3033 0.0912869708000101 4412 X1406 SGTC_3176 9106582 49.47 µM -1.3371537745645 0.0926327648559694 no 3034 0.0905862235886943 4375 17018027 SGTC_44 0929-0055 61.211 µM -1.33909369748879 0.092332878647608 no 3035 0.0902700859937603 4276 1379590 SGTC_1139 k015-0024 46.9 µM -1.33978954530085 0.092225485125399 no 3036 0.0901568877637314 4421 2766652 SGTC_1295 1013-0063 9.78 µM -1.34029168929317 0.0921480442944591 no 3037 0.0900752661612689 4425 6826038 SGTC_994 3910-0338 138 µM -1.3424436344992 0.0918167156752081 no 3038 0.0897260973595203 4465 3479481 SGTC_2402 5553605 200 µM -1.34811436035514 0.0909478387129694 no 3039 0.0888108016738745 4465 6758546 SGTC_1742 st038235 28.8875 µM -1.35801352102811 0.089445717191617 no 3040 0.0872296969134881 4437 564103 YBR002C RER2 SGTC_1124 fisetin 1.16336 µM -1.36011055637662 0.0891298903393995 no 3041 0.0868974705026162 4416 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2453 5731132 22.18 µM -1.36022248429909 0.0891130566424958 no 3042 0.0868797647410209 4443 1362040 SGTC_2225 6654152 15.4 µM -1.36325149136778 0.0886583990763862 no 3043 0.086401632128497 4338 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3269 9137823 49.47 µM -1.36581458502716 0.0882750270688444 no 3044 0.0859985836837009 4347 17682936 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.3708543918446 0.0875248087938534 no 3045 0.0852101756348336 4406 1377 SGTC_1946 st076057 65.1 µM -1.3717563549724 0.0873910473438277 no 3046 0.0850696491571852 4388 953009 SGTC_651 3253-0966 34.4 µM -1.37395973141424 0.0870649276111289 no 3047 0.0847270920940555 4429 781462 SGTC_356 1634-0012 32.5 µM -1.37836378079304 0.0864158137190493 no 3048 0.0840455000454299 4418 735457 SGTC_1003 4049-0218 100 µM -1.38563814660423 0.0853515782953651 no 3049 0.0829287119686389 4421 295161 SGTC_2934 9036370 36.88 µM -1.38641426886334 0.0852386142502345 no 3050 0.0828102209431034 4393 6462800 SGTC_2171 5739187 198.077 µM -1.38730785491871 0.0851086922083388 no 3051 0.0826739544689232 4374 2262761 SGTC_2396 5342950 42.78 µM -1.38833320853625 0.0849597948648425 no 3052 0.0825178022306068 4421 1886677 SGTC_696 1560-0013 611 µM -1.38908942431513 0.0848501057100741 no 3053 0.0824027796242587 4462 1650269 SGTC_2278 7948257 134.34 µM -1.38945011771522 0.0847978245201498 no 3054 0.0823479596558978 4432 1247028 SGTC_851 0394-0702 453 µM -1.39049950117547 0.0846458575870215 no 3055 0.0821886253394306 4445 762646 SGTC_3084 9116877 49.47 µM -1.40244140695389 0.0829308483062046 no 3056 0.080391737921074 4393 27241325 SGTC_1310 1188-0297 994 nM -1.4068038607109 0.0823109063005662 no 3057 0.0797427787313671 4316 1588352 SGTC_2447 5741742 33.78 µM -1.40808975457676 0.0821288374074086 no 3058 0.0795522472100405 4499 1776504 SGTC_2090 5301565 104.445 µM -1.4086871784409 0.0820443518309286 no 3059 0.0794638439102604 4451 2056344 SGTC_497 capsazepine 133 µM -1.40876028306665 0.0820340181305881 no 3060 0.0794530314214571 4388 2733484 A calcium channel blocker. SGTC_1039 k821-0043 94 µM -1.41105546134496 0.0817100818091903 no 3061 0.0791141306414394 4412 15992768 SGTC_245 methotrexate 289.6 µM -1.41121586672084 0.0816874786563524 no 3062 0.0790904865382556 4396 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2056 5235370 200 µM -1.41237497473943 0.0815242857076438 no 3063 0.0789197905024756 4361 5511916 SGTC_619 1652-1634 108 µM -1.41390591310796 0.0813091190375041 no 3064 0.0786947647736097 4432 5400454 SGTC_2182 6325192 200 µM -1.41396928774119 0.0813002212538433 no 3065 0.0786854601133989 4470 736248 SGTC_3177 9107506 49.47 µM -1.41833435484738 0.0806891329562703 no 3066 0.0780465855610296 4398 8897194 SGTC_1796 st049173 110.4 µM -1.42546359824769 0.0796985417813165 no 3067 0.0770116176785868 4439 94134 SGTC_911 3456-4043 236 µM -1.4259805733583 0.0796270686724119 no 3068 0.0769369748481716 4441 914281 SGTC_358 0075-0058 9.45 µM -1.42750759052817 0.0794162378785478 no 3069 0.0767168194220958 4415 1069125 SGTC_1346 1488-2224 62.4 µM -1.4277115804244 0.0793881056100802 no 3070 0.076687445791051 4471 3722427 SGTC_1997 st073024 93.8 µM -1.4317707347968 0.0788298744122632 no 3071 0.0761047226172796 4499 686268 SGTC_2899 9053889 58.44 µM -1.43493607699684 0.078396631544613 no 3072 0.0756526569898451 4442 6470052 SGTC_192 3455-0609 60.9 µM -1.43570017354692 0.0782923200542075 no 3073 0.0755438379206001 4524 3769639 SGTC_749 1000-0129 128 µM -1.43697783600852 0.0781181337313275 no 3074 0.0753621457006692 4483 708470 SGTC_1209 2323-2347 50.3 µM -1.44244084987458 0.0773766643723219 no 3075 0.0745890234312313 4472 5412760 SGTC_1560 lithocholic acid 53.1 µM -1.44476838279838 0.0770623879691311 no 3076 0.0742614773595931 4403 9903 A bile acid which acts as a detergent. SGTC_778 3456-2434 196 µM -1.44501003505858 0.0770298144082579 no 3077 0.07422753347161 4390 5539063 SGTC_2670 beta-carotene 100 µM -1.45902051401616 0.0751591062238931 no 3078 0.0722797308050159 4435 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2965 9082772 38.63 µM -1.46358959048797 0.0745565842857309 no 3079 0.071653059226558 4468 16459634 SGTC_1975 st070967 30.8 µM -1.46650331399612 0.07417428258732 no 3080 0.071255609513925 4459 261391 SGTC_1910 st062352 60.4 µM -1.46681940316302 0.0741328995817051 no 3081 0.071212594980348 4383 2245730 SGTC_2739 tacrine 100.86 µM -1.46730411407459 0.0740694745519495 no 3082 0.0711466725316865 4538 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2622 2-methoxyxanthone 59.94 µM -1.4772380740884 0.0727787158113952 no 3083 0.0698059155423163 4449 71034 A hepatoprotective. SGTC_2825 7998094 58.44 µM -1.47998579128567 0.0724247524107228 no 3084 0.0694385192973819 4452 2987815 SGTC_2645 abamectin 100 µM -1.48364046162128 0.07195600016417 no 3085 0.0689521645774533 4429 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1336 1486-0901 104 µM -1.48630088483361 0.0716162368483978 no 3086 0.068599776393415 4494 5006114 SGTC_2158 5657123 3.6195 µM -1.48725931020741 0.0714941381420566 no 3087 0.0684731683950295 4479 2858827 SGTC_3030 9087619 49.47 µM -1.48865572412559 0.0713165278459967 no 3088 0.0682890248625471 4495 25236973 SGTC_3247 9135149 49.47 µM -1.49270615165219 0.0708032686770585 no 3089 0.0677570611967788 4544 8934436 YOR116C RPO31 SGTC_2671 danthron 100 µM -1.4935041901732 0.0707024789034893 no 3090 0.0676526291236718 4490 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1004 4084-0029 199 µM -1.49357444616986 0.0706936110735726 no 3091 0.0676434413166076 4499 716894 YLR208W SEC13 SGTC_1972 st070201 17.4 µM -1.49721967466941 0.0702346758562478 no 3092 0.0671680537989676 4506 2829099 SGTC_2064 5220758 200 µM -1.49850967358629 0.0700728147251553 no 3093 0.0670004406030136 4520 788518 SGTC_2977 9011197 71.43 µM -1.50179937877266 0.0696613418110346 no 3094 0.0665744644098199 4527 2704722 SGTC_1233 0325-0408 14.2 µM -1.50211256728976 0.0696222656932662 no 3095 0.0665340199002819 4531 12874 SGTC_1718 roemerine 11.9335 µM -1.5038958695247 0.0694000869731987 no 3096 0.0663040903621427 4117 235224 An aporphine alkaloid with mutagenic activity. SGTC_2236 dapsone 200 µM -1.5045665255498 0.0693166724777401 no 3097 0.0662177789249237 4518 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3069 9117009 49.47 µM -1.50708434023045 0.0690042021846807 no 3098 0.0658945201062734 4489 41904981 SGTC_1640 st009078 66.4 µM -1.50986284076091 0.0686606410888394 no 3099 0.065539213081539 4463 690618 SGTC_1501 4491-0275 38.4 µM -1.50992284150013 0.0686532365859044 no 3100 0.0655315567714691 4503 5104718 SGTC_1654 st012436 41.8 µM -1.51091542372055 0.0685308344694626 no 3101 0.0654050003292539 4487 4323132 SGTC_327 1273-0057 3.96 µM -1.51180955286397 0.068420717460786 no 3102 0.0652911592488214 4407 3108138 SGTC_202 3594-0513 34.79 µM -1.51226529843745 0.0683646423921317 no 3103 0.0652331926135804 4581 708429 SGTC_2944 9067346 25.62 µM -1.51528104021315 0.0679944779109959 no 3104 0.0648506238315324 4430 6473075 SGTC_2150 5556613 200 µM -1.51656598807405 0.0678372290998488 no 3105 0.0646881490292191 4535 743190 SGTC_3262 9137218 49.47 µM -1.51736183356823 0.0677399763950951 no 3106 0.0645876772572645 4492 17650664 SGTC_1832 st054113 55 µM -1.517480958353 0.067725428560149 no 3107 0.0645726487455733 4521 1251267 SGTC_1498 4478-3555 97.6 µM -1.51970084808042 0.0674547710536364 no 3108 0.064293089183922 4504 3437919 SGTC_1420 4'-methoxyflavone 42 µM -1.52928791283907 0.0662954705502858 no 3109 0.0630965423758503 4503 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.5330454249169 0.0658453310603741 no 3110 0.0626323315060634 4491 521171 SGTC_1094 duloxetine 25.4 µM -1.53486372704984 0.0656283557634173 no 3111 0.0624086525519408 4523 60834 A selective serotonin reuptake inhibitor. SGTC_1405 3909-7894 12 µM -1.53621187639392 0.0654678412867659 no 3112 0.0622432120750158 4507 7104060 SGTC_1215 3852-0577 11.2 µM -1.54059474814826 0.0649481075754066 no 3113 0.0617077234620904 4540 2884876 SGTC_151 3013-0144 2.285 µM -1.54229714171854 0.0647470985808753 no 3114 0.0615007016097267 4272 906558 YHR107C CDC12 SGTC_2806 7952793 58.44 µM -1.54338975509839 0.0646183437196728 no 3115 0.061368118951834 4534 2972490 SGTC_1684 st024538 14.6195 µM -1.54805294352565 0.0640710625097958 no 3116 0.0608047751029753 4495 6732859 SGTC_2525 harmine 47.85 µM -1.54927212065877 0.0639285733457096 no 3117 0.0606581593611151 4526 5280953 A monoamine oxidase inhibitor SGTC_953 1188-0045 9.7 µM -1.55048515651125 0.0637870466254722 no 3118 0.060512556742447 4501 6144426 SGTC_2915 7971052 15.16 µM -1.55074884026637 0.063756314515479 no 3119 0.0604809425729834 4479 5741558 SGTC_2819 7996655 46.38 µM -1.55791070898724 0.0629260021561032 no 3120 0.0596272081296073 4498 6456960 SGTC_1288 0973-0013 65.5 µM -1.55831268127068 0.062879650297472 no 3121 0.059579572138619 4553 4315430 SGTC_1446 4239-0190 62 µM -1.56075462826755 0.0625986381785319 no 3122 0.0592908282311077 4525 1340085 SGTC_1876 myriocin 605 nM -1.5644464568233 0.0621756532961067 no 3123 0.0588563789469341 4513 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3277 9138724 49.47 µM -1.56483590402618 0.0621311633715444 no 3124 0.0588106953744373 4501 15943418 SGTC_51 1013-0126 23.419 µM -1.56617067701624 0.0619788691118227 no 3125 0.0586543327524573 4518 1627850 SGTC_56 0957-0365 83.25 µM -1.56662598671769 0.0619269860982058 no 3126 0.0586010699891569 4469 6752360 SGTC_3060 1327-0027 12.5 µM -1.57142198928442 0.061382533464689 no 3127 0.0580423308088223 4451 16000455 YPR107C YTH1 SGTC_1886 st057356 49.9 µM -1.57868874456385 0.0605647295572582 no 3128 0.0572037338779492 4521 24207747 SGTC_324 1315-0088 19.6 µM -1.58168113453504 0.0602304526001001 no 3129 0.0568611907837407 4504 6787421 SGTC_1434 4073-0095 163 µM -1.58211621697635 0.0601819704562718 no 3130 0.0568115210731804 4543 24133745 SGTC_3103 9120822 49.47 µM -1.58813088620034 0.0595148694037019 no 3131 0.0561283727194473 4543 17141819 SGTC_1553 gossypol 38.6 µM -1.59015273595352 0.059291927533835 no 3132 0.0559001906251199 4476 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_282 k297-0036 65.7 µM -1.59540691130408 0.0587156307276333 no 3133 0.0553106357543826 4541 5061378 SGTC_2518 prenyletin 46.28 µM -1.59576945832071 0.0586760279920404 no 3134 0.0552701372593217 4564 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2748 diazoxide 86.69 µM -1.59611722104104 0.0586380599208305 no 3135 0.0552313122615381 4626 3019 A potassium channel activatior. SGTC_2307 7538926 6.34 µM -1.59874362836449 0.0583519363073796 no 3136 0.0549387896153607 4498 96582 SGTC_1396 3511-0007 98.6 µM -1.60626217273863 0.057538918436748 no 3137 0.054108158976773 4575 X1396 SGTC_2256 7954252 200 µM -1.60766598561339 0.0573881089636936 no 3138 0.0539541759906699 4561 2972920 SGTC_112 phenothiazine 287.218 µM -1.60876848296306 0.0572698875270758 no 3139 0.0538334874220977 4513 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1352 1496-0991 99 µM -1.61160022066389 0.0569671168781136 no 3140 0.0535244813256562 4550 3000039 SGTC_2583 asiatic acid 100 µM -1.61199400512817 0.056925113270466 no 3141 0.0534816221299109 4549 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_234 nsc-17383 10.7 µM -1.61305848742034 0.0568116907383093 no 3142 0.0533659008032784 4554 408974 SGTC_814 3342-0569 96 µM -1.6187715531566 0.056205991379189 no 3143 0.0527482124505616 4591 4346283 SGTC_3064 1327-0027 10 µM -1.62294004997814 0.0557672688580347 no 3144 0.0523011104957154 4530 16000455 YPR107C YTH1 SGTC_2859 9028643 45.46 µM -1.62447899434706 0.0556059839326517 no 3145 0.0521368099563691 4392 17151580 SGTC_430 0958-0115 16.4 µM -1.62909636973097 0.0551242811433428 no 3146 0.0516463098126069 4488 6833180 SGTC_2871 9038510 12.99 µM -1.63075244240033 0.0549523185122016 no 3147 0.0514712830156248 4507 4945164 SGTC_3132 9126706 49.47 µM -1.63244176763683 0.0547773400717846 no 3148 0.0512932281800766 4569 850858 SGTC_2024 5144227 134 µM -1.64431612388365 0.0535598055579296 no 3149 0.0500554602334023 4538 3475211 SGTC_524 r073-0010 27.8 µM -1.64517763948548 0.0534723111506498 no 3150 0.0499665916637306 4502 2772106 SGTC_2298 7976326 193.81 µM -1.64866910581335 0.0531188813560294 no 3151 0.0496077213367435 4531 2235818 SGTC_1552 6-methylflavone 10.6 µM -1.6502485804456 0.0529596059365927 no 3152 0.049446052186002 4517 689013 SGTC_3300 9124615 50.48 µM -1.65511928270563 0.05247082467616 no 3153 0.0489501520854298 4566 24824903 SGTC_1275 0867-0008 21.1 µM -1.65801669823259 0.0521817682836486 no 3154 0.0486570480122822 4553 3422836 SGTC_1556 plumbagin 1.48 µM -1.66421617279502 0.0515675353371084 no 3155 0.0480346186190288 4504 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1175 0741-0056 27.6 µM -1.677500328274 0.0502707256194815 no 3156 0.0467223426610599 4636 765927 SGTC_2041 5107442 45.335 µM -1.68687787898409 0.0493710326313598 no 3157 0.0458134182172796 4600 793005 SGTC_1891 st059073 26.2 µM -1.6875383526636 0.0493081537391559 no 3158 0.0457499408665318 4634 688754 SGTC_3179 9107801 49.47 µM -1.6882401273027 0.0492414129640052 no 3159 0.0456825716094775 4565 4818259 SGTC_2707 st078556 66.6 µM -1.68938927253848 0.0491322817604523 no 3160 0.0455724277092082 4503 17250899 SGTC_673 1082-0474 110 µM -1.69171283296331 0.0489122097645449 no 3161 0.0453503701979791 4561 3098046 SGTC_2563 tomatine 8.54 µM -1.69178919219724 0.0489049909213278 no 3162 0.0453430875124213 4518 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_744 1594-0068 283 µM -1.69191787244417 0.0488928276844581 no 3163 0.0453308168910129 4576 668392 SGTC_2368 9071271 200 µM -1.69454431175798 0.0486450966535754 no 3164 0.0450809494421823 4572 27209959 SGTC_1579 chlormadinone acetate 49.4 µM -1.70085814797011 0.0480536676965132 no 3165 0.0444848135854923 4602 45114258 A steroidal progestin. SGTC_2285 7945142 200 µM -1.70278099852665 0.0478746982471186 no 3166 0.0443045300411511 4597 2970608 SGTC_1479 0549-0158 134 µM -1.70826277718638 0.0473674091260888 no 3167 0.0437937973714671 4636 5440202 SGTC_1634 st006576 41 µM -1.70912419454658 0.0472880857758947 no 3168 0.043713973393292 4568 3915356 SGTC_1289 0976-0073 69.1 µM -1.71100654278007 0.0471151208167901 no 3169 0.0435399525110134 4641 3391136 SGTC_670 4204-0025 119 µM -1.71443229190204 0.0468016378100637 no 3170 0.0432246810781335 4604 719039 SGTC_2398 5228213 48.84 µM -1.72194177177252 0.046120314683276 no 3171 0.0425400335148841 4551 80771 YMR134W ERG29 SGTC_2711 st079103 59.1 µM -1.72497424140477 0.0458474515364167 no 3172 0.0422660573540975 4536 54693780 SGTC_248 streptozotocin 5.23457 mM -1.72679181042786 0.0456845285448155 no 3173 0.0421025299124281 4633 5300 DNA alkylating agent. SGTC_3217 9129673 49.47 µM -1.73185645876559 0.0452329985444216 no 3174 0.0416495614075472 4563 17248312 SGTC_3319 9138450 16.7555 µM -1.73337394419953 0.0450984110063436 no 3175 0.0415146128210897 4553 2029690 SGTC_128 0906-2981 13.371 µM -1.73682106577386 0.0447938792011542 no 3176 0.0412093797592941 4594 6740226 SGTC_3164 9100705 49.47 µM -1.73967678153652 0.0445428503961187 no 3177 0.0409578942705534 4625 17174235 SGTC_115 0527-0192 112.043 µM -1.74291935112529 0.0442591908811851 no 3178 0.0406738516621305 4568 4233931 SGTC_271 rotenone 740 µM -1.74504038834539 0.0440744318309236 no 3179 0.0404889194273977 4637 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2829 7992743 58.44 µM -1.7459267426967 0.0439974078494596 no 3180 0.0404118411179604 4575 16462845 SGTC_808 0711-0032 135 µM -1.75449154723692 0.0432587075162493 no 3181 0.0396731585121751 4579 4252555 SGTC_1114 scopoletin 1.73284 µM -1.75706702053159 0.0430385463689591 no 3182 0.0394531931266335 4639 5280460 A coumarin with genotoxic properties. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.76017006130339 0.0427744900924662 no 3183 0.0391894882664236 4616 688662 SGTC_2914 7968218 45.32 µM -1.76476948504502 0.0423855082002127 no 3184 0.0388012575574086 4604 2977111 SGTC_3197 9113331 49.47 µM -1.76709383821391 0.0421900244418855 no 3185 0.038606257139964 4582 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3249 9135183 49.47 µM -1.7715003765707 0.0418214267310168 no 3186 0.0382387650588551 4562 4902779 SGTC_959 1222-0044 107 µM -1.7745718310817 0.0415660515800534 no 3187 0.0379843059101667 4610 6083612 SGTC_3126 9127922 49.47 µM -1.77635864117968 0.0414180700109686 no 3188 0.0378369117158588 4569 45595682 SGTC_199 4063-0024 41.6 µM -1.77743886170486 0.0413288146538202 no 3189 0.0377480307977971 4659 306215 SGTC_564 3555-0129 330 µM -1.78070803769503 0.0410596420372988 no 3190 0.0374800796974183 4563 563260 SGTC_2097 5376186 200 µM -1.78101272235316 0.0410346279515921 no 3191 0.0374551861915081 4600 742755 SGTC_769 0302-0231 76 µM -1.79569050836981 0.0398441708026136 no 3192 0.0362718761348859 4558 571869 YER009W NTF2 SGTC_2091 4-phenylthiadiazole 200 µM -1.79771683465439 0.0396820512572488 no 3193 0.0361109461286017 4638 270010 SGTC_2745 rifampicin 24.3 µM -1.80798876094174 0.0388684613669345 no 3194 0.0353041249109247 4730 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1079 idarubicin 2.36 µM -1.80863480152192 0.0388177490549247 no 3195 0.0352538790548868 4646 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1243 0416-0003 5.65 µM -1.80904012528753 0.0387859598364431 no 3196 0.0352223849252778 4608 2141977 SGTC_185 k048-0037 25.491 µM -1.81425654090636 0.0383787300373045 no 3197 0.0348191194894896 4669 6827589 SGTC_2639 lactacystin 53 µM -1.81613112510884 0.0382332409982591 no 3198 0.0346751300971931 4628 3870 A proteasome inhibitor. SGTC_2123 5259487 200 µM -1.8269344934392 0.0374035181935852 no 3199 0.0338548096128995 4633 2173474 SGTC_879 0831-1030 162 µM -1.82857170287504 0.0372790697662593 no 3200 0.0337318975034902 4641 1549252 SGTC_2320 7373003 200 µM -1.82918886365084 0.0372322456972673 no 3201 0.0336856600789396 4600 5415828 SGTC_816 0325-0417 81.3 µM -1.83652463121088 0.0366793517007195 no 3202 0.0331400513215679 4655 68101 SGTC_1285 0929-0069 65.5 µM -1.83802523786385 0.0365670830505915 no 3203 0.0330293432403863 4666 1206237 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.85077358657022 0.0356246057929059 no 3204 0.0321010662549344 4639 803109 SGTC_3107 9121808 49.47 µM -1.85196690388093 0.0355374131091967 no 3205 0.0320152877815352 4603 662681 SGTC_1453 4237-0541 195 µM -1.85307791920476 0.0354563913722071 no 3206 0.0319355955960712 4648 739892 SGTC_3152 9099253 49.47 µM -1.86077998504451 0.0348988673204363 no 3207 0.0313876265422822 4496 25236131 SGTC_2237 6667747 47.222 µM -1.86390393313291 0.0346747971378591 no 3208 0.0311675981534927 4645 729940 YDL015C TSC13 SGTC_604 1000-0114 314 µM -1.86863904254666 0.0343374176647765 no 3209 0.0308365250305995 4657 1572745 SGTC_65 0798-0905 34.986 µM -1.87475594794095 0.0339055826160759 no 3210 0.030413153038875 4612 3602145 SGTC_3251 9135047 49.47 µM -1.87880683786992 0.0336220682769103 no 3211 0.0301354365235065 4686 17682963 SGTC_2809 7964133 12.99 µM -1.88800639977112 0.0329854506507052 no 3212 0.0295125456468218 4632 1253665 SGTC_1208 2323-2347 50.3 µM -1.89091826082331 0.0327860292567202 no 3213 0.0293176282001454 4657 5412760 SGTC_618 k072-0232 33.2 µM -1.89293866643435 0.0326482449171221 no 3214 0.0291830132048247 4679 5872756 YGL099W LSG1 SGTC_1701 st028638 40.4 µM -1.90017474479542 0.0321586829308502 no 3215 0.0287050956971667 4657 3490878 SGTC_3183 9108214 49.47 µM -1.90177715457412 0.0320510943812754 no 3216 0.0286001470818266 4681 4974831 SGTC_1505 k297-0037 20.6 µM -1.90323280714794 0.031953617146965 no 3217 0.0285050870429297 4644 4089396 SGTC_2879 9041815 71.43 µM -1.90610574630811 0.0317619502546575 no 3218 0.0283182436628966 4690 4942971 SGTC_1170 0310-0127 64.8 µM -1.91436960995417 0.0312159195675953 no 3219 0.0277864728881882 4666 774975 SGTC_1054 3429-0080 167 µM -1.91972126150805 0.0308664713449172 no 3220 0.0274465585798206 4654 1162877 SGTC_3048 9093155 49.47 µM -1.92014798940133 0.0308387471242934 no 3221 0.0274196045298841 4671 25236002 SGTC_2856 9022925 19.48 µM -1.9221121617939 0.0307114018543327 no 3222 0.0272958230469099 4660 4944862 SGTC_1248 0469-0687 58.6 µM -1.93312287747572 0.0300055696889703 no 3223 0.0266105312252659 4625 4017482 SGTC_807 1315-0151 48 µM -1.93565690833754 0.0298450463714971 no 3224 0.0264548677275659 4659 4011080 SGTC_297 0986-0032 24 µM -1.94204305868652 0.0294436603269273 no 3225 0.0260659439255995 4646 2847425 SGTC_3236 9132701 49.47 µM -1.9481038333038 0.0290668801498114 no 3226 0.025701270121311 4691 24282524 SGTC_111 0083-0039 52.457 µM -1.95012270352032 0.0289422660135464 no 3227 0.0255807479161955 4655 759313 SGTC_3016 9080866 49.47 µM -1.95126307853224 0.0288720731760387 no 3228 0.0255128793702505 4662 17066299 SGTC_938 3126-1755 342 µM -1.954521535651 0.028672286728743 no 3229 0.025319785273903 4665 1777771 SGTC_2764 methyldopa 94.69 µM -1.95862436164589 0.0284223657806411 no 3230 0.0250783972054369 4632 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_842 0271-0008 11.1 µM -1.96170370087233 0.0282359828557163 no 3231 0.0248984953614235 4680 1221709 SGTC_1561 5-methoxyflavone 52.9 µM -1.96370355164593 0.0281154838106543 no 3232 0.0247822402487621 4661 94525 SGTC_1401 3807-4679 7.6 µM -1.96746319634932 0.0278901091369554 no 3233 0.0245649174301756 4609 3291456 SGTC_1168 k815-0004 80.5 µM -1.97753833734588 0.0272935573382265 no 3234 0.0239904057448813 4670 642433 SGTC_1390 3413-2614 145 µM -1.97836362254575 0.0272451671806289 no 3235 0.0239438502270013 4673 3421432 SGTC_672 1441-0018 53.7 µM -1.99551482750897 0.0262556037911644 no 3236 0.0229933793074697 4706 251141 SGTC_829 1635-0120 117 µM -2.00050897364721 0.0259731724486078 no 3237 0.0227226659520627 4669 285054 SGTC_2572 astragaloside iv 100 µM -2.01045018406776 0.02541853383097 no 3238 0.0221917818123248 4637 45006101 An anti-inflammatory agent. SGTC_1794 st048918 76.9 µM -2.01610015944946 0.0251077563595575 no 3239 0.0218947516957629 4680 672303 SGTC_2669 eugenol 100 µM -2.01981121620203 0.0249053671892463 no 3240 0.0217014866376752 4717 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_479 n-linoleoylglycine 10 µM -2.02196617499739 0.0247884717382359 no 3241 0.0215899231990483 4706 6433346 An anti-infammatory. SGTC_1773 st048542 73.5835 µM -2.02505530605531 0.0246217051998233 no 3242 0.0214308427635325 4680 3237138 SGTC_674 0498-0004 451 µM -2.02621932736019 0.0245591102666608 no 3243 0.0213711569535236 4672 4231473 SGTC_3139 9095020 49.47 µM -2.02925572065074 0.0243964572970893 no 3244 0.0212161254102028 4612 25236292 SGTC_646 4092-0839 27.3 µM -2.04073131391335 0.023789879915363 no 3245 0.020638770525528 4706 877796 SGTC_1222 0366-0074 1.18 µM -2.04235816917829 0.0237049224241265 no 3246 0.0205580079652459 4704 286520 SGTC_2742 clothiapine 36.27 µM -2.04976072250006 0.023321561672544 no 3247 0.0201938931016468 4720 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1769 st044406 64.4 µM -2.05304359301221 0.0231532271446507 no 3248 0.0200341749074879 4683 670903 SGTC_1254 0550-0035 264 µM -2.0683552636203 0.0223815492102572 no 3249 0.019303314329052 4679 15121435 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.07024246866572 0.0222879568803786 no 3250 0.019214822054349 4678 551469 SGTC_649 1123-0311 367 µM -2.07110860108573 0.0222451133658165 no 3251 0.0191743241272117 4612 693629 YIL048W NEO1 SGTC_2532 xanthone 78.9 µM -2.07382312749351 0.0221112883628147 no 3252 0.0190478702188652 4700 7020 An insecticide. SGTC_2060 5238662 140 µM -2.09071836076664 0.0212935488794822 no 3253 0.0182766590529528 4675 790130 SGTC_251 melphalan 456.522 µM -2.09126996806894 0.0212672877420827 no 3254 0.0182519351725137 4728 460612 A DNA alkylator. SGTC_1871 st057448 67.3 µM -2.09522559870919 0.0210797678634266 no 3255 0.0180754713556784 4699 691747 SGTC_1031 k035-0009 16 µM -2.0981912486631 0.0209400980968183 no 3256 0.0179441271895373 4728 5180959 SGTC_194 1486-1323 56.904 µM -2.09973538327032 0.0208676863968519 no 3257 0.0178760625924185 4759 5178754 SGTC_2282 7944268 200 µM -2.10447646349939 0.0206466782104387 no 3258 0.0176684528046575 4684 2970414 SGTC_416 estradiol valerate 100 µM -2.10921004631041 0.0204280005793202 no 3259 0.0174632275688983 4700 13791 A steroid. SGTC_2337 9009472 200 µM -2.11238165999894 0.0202825820747977 no 3260 0.0173268633841742 4653 5742383 SGTC_2075 5212009 200 µM -2.117399285172 0.0200543166597719 no 3261 0.0171129874111001 4680 780898 SGTC_1255 0566-0045 221 µM -2.11819673093838 0.0200182401168337 no 3262 0.0170792049695925 4699 2788469 SGTC_1930 st074634 34.3 µM -2.13881477785774 0.0191044117768344 no 3263 0.0162253360758916 4650 684253 YOR116C RPO31 SGTC_730 1436-0052 41.2 µM -2.14248379842623 0.0189455687784779 no 3264 0.016077285518546 4725 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3323 9138564 53.9225 µM -2.14627081190877 0.018782797033296 no 3265 0.0159256894421344 4724 43912313 YNL103W MET4 SGTC_1214 0358-0031 63.7 µM -2.14793390710262 0.0187116915360242 no 3266 0.0158595031528136 4697 4301366 SGTC_534 k292-0788 63.4 µM -2.14802164393662 0.0187079467253438 no 3267 0.0158560180448716 4731 4146317 SGTC_1367 1812-0510 76.9 µM -2.16317222824737 0.0180707788127559 no 3268 0.0152639677162014 4722 1142582 YDR527W RBA50 SGTC_1387 3342-1166 1.8 µM -2.18322293257921 0.01725604940495 no 3269 0.0145096983715899 4730 3418228 SGTC_511 blebbistatin 171 µM -2.19147875471237 0.0169298229887314 no 3270 0.0142085827543464 4730 3476986 A myosin inhibitor. SGTC_1606 st000094 49.2 µM -2.19917201169386 0.0166305871261376 no 3271 0.0139328468265697 4742 1242210 SGTC_2586 curcumin 80 µM -2.20225302088861 0.0165120241067985 no 3272 0.0138237203352633 4641 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2466 5983409 37.09 µM -2.20289778986455 0.0164873039465202 no 3273 0.0138009767212991 4736 2879657 SGTC_1730 st033808 45.1 µM -2.21109001540826 0.0161759659077114 no 3274 0.0135148021176284 4669 1045166 SGTC_189 3970-0742 2.116 µM -2.21485391001084 0.016034619789008 no 3275 0.0133850467601084 4731 2891807 SGTC_1751 st044839 27.194 µM -2.23284890181486 0.0153733899040149 no 3276 0.0127794551020601 4745 5291326 SGTC_943 3253-1379 105 µM -2.23693672671986 0.0152264886174305 no 3277 0.0126452378726905 4703 668464 SGTC_644 1498-1197 63.3 µM -2.23983106171651 0.0151232075039991 no 3278 0.0125509462552019 4749 6741615 SGTC_936 3005-4620 401 µM -2.25214945532078 0.0146903450170414 no 3279 0.012156414450729 4733 777207 SGTC_477 mead ethanolamide 10 µM -2.25987016746359 0.0144245118983981 no 3280 0.0119146549641539 4764 16061185 SGTC_3001 9076041 71.4286 µM -2.26348175407713 0.0143015892826056 no 3281 0.0118030040587608 4727 16004211 SGTC_1509 1326-1131 80 µM -2.28766155684335 0.0135016253775961 no 3282 0.0110786190474355 4730 768313 SGTC_280 3448-3607 3.04 µM -2.30591224604026 0.0129236824835928 no 3283 0.0105577681129343 4730 626179 SGTC_937 3122-0005 46.7 µM -2.30793778871541 0.0128608783192415 no 3284 0.0105012984463655 4722 759535 SGTC_2099 5377090 177.372 µM -2.31083695647511 0.0127714458366873 no 3285 0.0104209311797694 4742 2243829 SGTC_1602 st001878 87.6 µM -2.31854108945979 0.012536401530505 no 3286 0.0102099662684845 4717 595405 YLR310C CDC25 SGTC_1787 fluconazole 80 µM -2.32600715541626 0.0123122029360589 no 3287 0.0100090844808987 4426 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_31 0508-1974 57.237 µM -2.32627937525571 0.0123040945008178 no 3288 0.0100018257848281 4713 6810525 SGTC_859 0439-0102 54.6 µM -2.32943742403396 0.0122103653977121 no 3289 0.00991795221203066 4754 610143 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.33272964193754 0.01211331361169 no 3290 0.00983116971087062 4720 17037758 SGTC_2949 9072542 2.23 µM -2.33484782160133 0.0120512256111773 no 3291 0.00977568598637301 4702 16457352 SGTC_1924 st058459 75.1 µM -2.35841719724144 0.011378766980005 no 3292 0.00917652686126192 4730 688683 SGTC_1210 3013-0140 750 nM -2.36315463365812 0.0112476100576668 no 3293 0.00906005355660327 4755 905973 SGTC_1907 st060210 83.7 µM -2.36677936779996 0.0111481478261359 no 3294 0.0089718130824487 4738 688793 SGTC_1938 st074717 56.4 µM -2.40091300189447 0.0102484275279491 no 3295 0.0081771120634508 4701 17250979 SGTC_718 1130-0073 349 µM -2.43375335965587 0.00944324319698576 no 3296 0.00747158671452619 4764 6740020 SGTC_732 3970-1727 52.7 µM -2.43817908205062 0.0093390778523755 no 3297 0.0073807295569673 4765 1275699 SGTC_95 0471-0001 561.058 µM -2.44115864868818 0.00926951719735791 no 3298 0.00732011080051891 4747 4015405 SGTC_2205 7238770 200 µM -2.44948847645482 0.00907744994996748 no 3299 0.00715296436977863 4759 279867 SGTC_1644 st010134 20.9 µM -2.47067439597551 0.00860457266029174 no 3300 0.00674292725714314 4752 3818134 SGTC_284 0988-0104 32.6 µM -2.48440874112908 0.00830968925453156 no 3301 0.00648833821162037 4746 4666532 SGTC_2543 pimpinellin 60.67 µM -2.48721771594101 0.00825048420936295 no 3302 0.006437329097443 4685 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1988 st071872 53.4 µM -2.52400943190694 0.00750855094385016 no 3303 0.00580124078052217 4777 16414116 SGTC_568 1193-0097 7.48 µM -2.53069960001799 0.0073801430419714 no 3304 0.00569176477791766 4608 3646150 SGTC_116 0155-0182 31.788 µM -2.5444094487845 0.00712303508804661 no 3305 0.00547313444559648 4698 771486 SGTC_2870 9038528 12.99 µM -2.55554527600272 0.00692004873941909 no 3306 0.0053010783622831 4758 6463316 SGTC_1010 4112-3296 15.2 µM -2.55994982441652 0.00684118208292791 no 3307 0.00523436383712365 4769 704384 SGTC_1648 st011736 69.8 µM -2.5885046061881 0.00634887544284774 no 3308 0.00481968289049623 4772 2855514 SGTC_1203 3992-3522 103 µM -2.59481967361817 0.00624433022245128 no 3309 0.00473202791679043 4743 5322312 SGTC_110 0850-0284 111.64 µM -2.61429701921279 0.0059314228600309 no 3310 0.00447056352604228 4757 3906265 SGTC_1320 1313-0481 95.3 µM -2.61468120233815 0.0059253932883182 no 3311 0.004465538632966 4749 6813365 YLR208W SEC13 SGTC_2415 st077333 57.7 µM -2.61811168556726 0.00587179398436086 no 3312 0.00442089304134752 4747 2766255 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.6316160969921 0.00566495074019923 no 3313 0.00424899136210103 4773 1241132 A phosphatase inhibitor. SGTC_84 0443-0269 128.823 µM -2.65341086550786 0.00534475123913538 no 3314 0.00398414063604331 4764 6150058 SGTC_526 4469-0568 170 µM -2.6810184836152 0.00496231204249005 no 3315 0.00366992308310958 4760 2901964 SGTC_1101 ebselen 5.29 µM -2.69986633815252 0.00471541634635446 no 3316 0.00346836693580296 4790 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1793 st048256 72.231 µM -2.70321099723634 0.00467276648801377 no 3317 0.00343365689986572 4782 672022 SGTC_1752 st044819 83.042 µM -2.72149713334694 0.00444561666179839 no 3318 0.00324934743746162 4756 441209 YML126C ERG13 SGTC_2946 9065502 71.43 µM -2.72622722553679 0.00438848882775259 no 3319 0.00320314397054844 4746 16489101 SGTC_1330 1469-0054 61.8 µM -2.76775729973676 0.00391439826000013 no 3320 0.0028221735716096 4768 7102664 SGTC_1923 st058458 19.1 µM -2.77011360376821 0.0038889295969758 no 3321 0.00280183720334649 4773 3534982 SGTC_193 1273-0060 1.558 µM -2.83774969086336 0.00321835326470989 no 3322 0.00227163980484468 4743 2847393 YHR072W ERG7 SGTC_1503 4585-0012 61.3 µM -2.84291533656052 0.00317168976841667 no 3323 0.00223514717500141 4786 2922052 SGTC_503 tyrphostin 8 294 µM -2.86350334413538 0.00299169970310365 no 3324 0.00209492195646367 4784 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_213 1246-0773 967 nM -2.87905793105016 0.00286187495802571 no 3325 0.00199432529236198 4791 6251622 SGTC_2519 cryptotanshinone 88.04 µM -2.88638544340465 0.00280249552074376 no 3326 0.00194847291646236 4777 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_716 1683-5115 658 µM -2.88749194545368 0.00279362608736925 no 3327 0.00194163274130189 4774 723597 SGTC_1237 0330-0133 46.1 µM -2.8927790112968 0.00275159498656013 no 3328 0.00190924930071965 4776 X1237 YHR072W ERG7 SGTC_2866 9034245 58.44 µM -2.91414452362721 0.00258749590085801 no 3329 0.00178332373408679 4792 6462273 SGTC_2626 ethyl orsellinate 100 µM -2.94279212010757 0.00238134915994027 no 3330 0.00162633375553691 4765 75653 A natural product. SGTC_2387 9077560 195.08 µM -2.95479372236394 0.00229949473427655 no 3331 0.00156439083988221 4784 5303272 SGTC_2747 doxorubicin 7.63 µM -2.98863491115098 0.00208222668340057 no 3332 0.00140113377389176 4806 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_947 3447-0010 211 µM -2.99297724008975 0.00205573955273974 no 3333 0.00138135175629608 4770 748350 SGTC_2384 9036245 200 µM -3.04036649854379 0.00178592018754504 no 3334 0.00118145210203478 4791 6462766 SGTC_2763 lisinopril 49.32 µM -3.06775393964606 0.0016450865399162 no 3335 0.00107837063497557 4778 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_57 miconazole 162.5 nM -3.09574142539998 0.00151168811512694 no 3336 0.000981607398994522 4717 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2921 7974240 10.71 µM -3.13415477511538 0.00134464223706141 no 3337 0.000861749611079488 4787 2979074 YDR527W RBA50 SGTC_1050 3232-1156 69.3 µM -3.16822372953092 0.00121079069740642 no 3338 0.000766867209526757 4790 700529 SGTC_2738 aclarubicin 5.55 µM -3.26888287521721 0.000883361181599205 yes 3339 0.000539864930844878 4804 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2746 daunorubicin 9.88 µM -3.3457388407965 0.000690529305672738 yes 3340 0.000410318244414985 4807 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_211 3455-0679 143.504 µM -3.37738164053425 0.000623074444790537 yes 3341 0.000365897196878638 4754 748649 SGTC_650 1328-0195 38 µM -3.39233355783947 0.000593365495211625 yes 3342 0.000346500103905039 4800 2780821 SGTC_2926 9010726 65.15 µM -3.4869169127388 0.00043377834884543 yes 3343 0.000244311567477631 4795 2994293 SGTC_1525 8-methoxypsoralen 92.5 µM -3.5515206312848 0.000348749518826744 yes 3344 0.000191505981813694 4800 4114 Related to psoralen; DNA damaging agent. SGTC_3199 9111318 49.47 µM -3.65520847106437 0.000243967686256567 yes 3345 0.0001284865373953 4787 8548020 SGTC_626 0214-0009 33 µM -3.66186542776628 0.000238362861096201 yes 3346 0.000125192691862409 4804 3437874 SGTC_1652 st011932 78 µM -3.77052614171823 0.000162272629585356 yes 3347 8.14518680682595e-05 4801 1551076 SGTC_1779 st039427 55 µM -3.88368182665331 0.000107611797365838 yes 3348 5.14432631595924e-05 4799 1124498 SGTC_2608 thymoquinone 42.66 µM -4.04438448302347 5.89705296635041e-05 yes 3349 2.62303832616207e-05 4804 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_164 4100-3994 89.624 µM -4.13690297516807 4.13083470853875e-05 yes 3350 1.76012434598005e-05 4801 4615967 SGTC_310 1273-0058 1.06 µM -4.23208805128072 2.84295205577967e-05 yes 3351 1.15765862937228e-05 4641 2734232 SGTC_2919 7978188 46.38 µM -4.79640503016289 2.65757604124578e-06 yes 3352 8.076924496075e-07 4806 2980291 SGTC_299 1273-0059 1.44 µM -4.82345693561909 2.35636998117289e-06 yes 3353 7.05456203380578e-07 4771 2848077 SGTC_1052 3253-3998 198 µM -5.7968385858501 2.06407183344556e-08 yes 3354 3.3788337642376e-09 4807 5450317 SGTC_1252 0493-0875 34.8 µM -6.61629189379723 2.05527193156583e-10 yes 3355 1.84160381666599e-11 4809 3960963 SGTC_1246 0422-0085 105 µM -11.2682576265423 1.66292166941066e-26 yes 3356 9.41292062386788e-30 4809 264295