SGTCid condition conc unit ISM1|YPL040C.score ISM1|YPL040C.strain.pval ISM1|YPL040C.strain.significant ISM1|YPL040C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_173 1273-0061 2.693 µM 16.0606344533587 2.65750594084616e-43 yes 1 2.40799918575803e-58 7 2847414 YPL266W DIM1
SGTC_310 1273-0058 1.06 µM 12.850938692472 1.6613771097243e-28 yes 2 4.24864163460204e-38 18 2734232
SGTC_236 1509-0011 5.31 µM 12.316260408681 2.35464598320113e-26 yes 3 3.70245832936911e-35 144 3107280
SGTC_275 trichlorophene 5.69 µM 10.4685232368001 1.31693079654896e-19 yes 4 6.02541267017234e-26 39 62616
SGTC_2250 alverine citrate 130 µM 9.43970186692337 2.6028773019121e-16 yes 5 1.86920779979327e-21 11 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1623 st003709 20.3 µM 8.11197032752837 1.52378401867612e-12 yes 6 2.49027323752868e-16 6 16192618
SGTC_831 k061-1017 217 µM 6.97583407393681 9.41168709737969e-10 yes 7 1.52030711553955e-12 5 1240153
SGTC_2232 chlorophetanol 41.5365 µM 6.32415085833763 2.48354066099171e-08 yes 8 1.27314436755355e-10 37 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2254 7938975 95.19 µM 5.80293552408191 2.74327923300216e-07 yes 9 3.25819270954547e-09 23 2969277
SGTC_2078 5212016 200 µM 5.73046190605882 3.77359930331917e-07 yes 10 5.00787597797794e-09 2 1899708
SGTC_28 pentachloropyridine N-oxide 1.606 µM 5.7223076193766 3.91054394505253e-07 yes 11 5.25434046583752e-09 19 140250 A respiratory chain inhibitor.
SGTC_832 4083-0019 164 µM 5.40363586036105 1.51846706155207e-06 yes 12 3.26517253534173e-08 28 1990758
SGTC_911 3456-4043 236 µM 5.34297960771537 1.9500766040085e-06 yes 13 4.57155263844168e-08 8 914281
SGTC_70 0141-0289 43.283 µM 5.22742753006183 3.11844295712344e-06 yes 14 8.59423675281508e-08 108 352408
SGTC_908 3448-7491 47.7 µM 4.98666498513496 8.04935313266327e-06 yes 15 3.07152249238277e-07 78 1203031
SGTC_63 0099-0242 26.702 µM 4.95241675633476 9.18160251108063e-06 yes 16 3.66487074386551e-07 59 3898502 YLR359W ADE13
SGTC_2533 agelasine 13.65 µM 4.90952438864898 1.08144102645832e-05 yes 17 4.56487727838505e-07 26 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2825 7998094 58.44 µM 4.90939902471254 1.08195647347017e-05 yes 18 4.56779620434857e-07 15 2987815
SGTC_2748 diazoxide 86.69 µM 4.76705729769885 1.84555514889605e-05 yes 19 9.34680800718964e-07 2 3019 A potassium channel activatior.
SGTC_10 0279-0212 42.575 µM 4.75258921905548 1.9469644577535e-05 yes 20 1.00414051405952e-06 74 39851 YBR002C RER2
SGTC_19 0279-0214 38.434 µM 4.66445306003335 2.68853040950325e-05 yes 21 1.54719476747322e-06 25 3566274 YBR002C RER2
SGTC_2488 5268135 45.7 µM 4.66235057719136 2.7091300422174e-05 yes 22 1.56309027521338e-06 32 1270356 YLR208W SEC13
SGTC_2077 5212015 200 µM 4.42951418914777 6.19041811807378e-05 yes 23 4.72227997090215e-06 50 780900
SGTC_1961 st076550 68.7 µM 4.28563807460945 0.000101243552969604 yes 24 9.11077163599502e-06 9 1579337
SGTC_820 1582-0060 59.9 µM 4.27330008017097 0.000105535953291468 yes 25 9.63004867099317e-06 24 3848840
SGTC_68 0986-0284 82.829 µM 4.27044725805141 0.000106552492883695 yes 26 9.75406760819311e-06 54 423278 YIL048W NEO1
SGTC_1596 piperlongumine 63 µM 4.20809761262729 0.000131203312568396 yes 27 1.28764811829378e-05 12 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2045 5106652 78.05 µM 4.15949317921514 0.000154026948422713 yes 28 1.594772724971e-05 9 673349
SGTC_2402 5553605 200 µM 4.15366691792123 0.000156999651139114 yes 29 1.63594670939624e-05 16 6758546
SGTC_1151 3909-8316 15.3 µM 4.11550068298477 0.000177841268687563 yes 30 1.93169926656109e-05 14 800431
SGTC_767 0929-0023 86 µM 4.11042937652591 0.000180797694561809 yes 31 1.97462029109366e-05 70 1204563
SGTC_2041 5107442 45.335 µM 4.09426287636207 0.000190531937435246 yes 32 2.11756796415554e-05 25 793005
SGTC_834 0312-0008 75.7 µM 4.06100344870909 0.000212118283229484 yes 33 2.44311248207256e-05 28 6385573 YIL048W NEO1
SGTC_1125 tnp00248 1.32998 µM 3.95038698576885 0.000301461948632051 yes 34 3.90124669545802e-05 25 24207736
SGTC_314 1671-0008 2.74 µM 3.92182289153259 0.000329656592236978 yes 35 4.3940790204877e-05 54 3913060
SGTC_1091 telmisartan 47.6 µM 3.9166695767579 0.000334997277302354 yes 36 4.48903348475924e-05 14 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2721 ifenprodil 61.44 µM 3.90130920135417 0.000351397165719997 yes 37 4.78369269201984e-05 19 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_440 fluspirilene 35.1 µM 3.88899944419252 0.00036507521930044 yes 38 5.03291742298144e-05 14 3396 An atypical antipsychotic.
SGTC_127 0180-0333 59.125 µM 3.87826163902343 0.000377408786545204 yes 39 5.26027686308072e-05 46 771601
SGTC_1622 st003707 19.4 µM 3.8362595688991 0.000429464345747508 yes 40 6.24611878599085e-05 44 10140899
SGTC_383 2324-0395 7.37 µM 3.78955981224272 0.000495114288773008 yes 41 7.54572359768733e-05 40 3146421
SGTC_503 tyrphostin 8 294 µM 3.78183624138801 0.000506828115323132 yes 42 7.7837882048964e-05 35 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1883 5-benzylidenerhodanine 20 µM 3.76902779701518 0.00052682073152878 yes 43 8.19423188979326e-05 76 1273210
SGTC_1022 4477-0945 21.3 µM 3.67437160555572 0.000698765449014946 yes 44 0.000119217752608486 34 4648966
SGTC_1692 fluoroquinolonic acid 71 µM 3.67373439581687 0.000700080934912103 yes 45 0.000119515600550044 7 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2260 7964312 200 µM 3.6664982253344 0.000715180681147445 yes 46 0.000122947312380182 20 231951
SGTC_1468 k284-1086 134 µM 3.63283764503077 0.000789446719146182 yes 47 0.000140160704321924 54 15996457
SGTC_2288 7946289 167.31 µM 3.6203799129542 0.000818687314237809 yes 48 0.000147085379801155 37 1246052
SGTC_2866 9034245 58.44 µM 3.5170268261817 0.00110255406791374 no 49 0.000218204836745883 14 6462273
SGTC_1471 k673-0312 37 µM 3.51009699530034 0.00112449100900179 no 50 0.000223971630236979 19 24099884
SGTC_1597 7-benzyloxygramine 47.5 µM 3.48266663023134 0.00121530506263474 no 51 0.000248223078466391 162 260807
SGTC_1627 st003713 25.6 µM 3.46054914141311 0.00129336481166457 no 52 0.00026953741639398 105 16195070 YER133W GLC7
SGTC_1703 st026983 48.3 µM 3.36443198711566 0.00168868098089423 no 53 0.000383506930641013 23 1104023
SGTC_601 0986-0029 62.9 µM 3.35759450068719 0.00172061702197789 no 54 0.000393119311811327 62 24747981
SGTC_1631 benzylvanillin 81.9 µM 3.33994689358367 0.00180560077866221 no 55 0.000418972059650639 54 75506
SGTC_119 0121-0043 24.815 µM 3.27707716430136 0.00214029193245481 no 56 0.000524438500844604 166 1092378
SGTC_1096 rimcazole 32.2 µM 3.25862256543534 0.00224870402770881 no 57 0.000559772523630045 26 18528119 A dopamine reuptake inhibitor.
SGTC_1476 4112-3294 3.34 µM 3.24437209492598 0.00233579689636344 no 58 0.000588549344129543 39 704369
SGTC_791 1348-1292 225 µM 3.21181794900095 0.00254631829478952 no 59 0.000659489643623119 76 5437054
SGTC_979 1426-2828 121 µM 3.14787509606787 0.00301043492348748 no 60 0.000822309754715751 56 747872
SGTC_1524 corynanthine 62.1 µM 3.13825485572319 0.00308650323057392 no 61 0.000849785167137494 52 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2284 7945075 39.21 µM 3.13786558985546 0.00308961731538986 no 62 0.000850914484240603 61 1245402
SGTC_118 0083-0097 135.343 µM 3.11591165592684 0.00326989226538351 no 63 0.000916886003455951 245 5207356
SGTC_427 1354-0053 47.3 µM 3.11558204084321 0.00327266953542698 no 64 0.000917911367644143 57 6813657
SGTC_195 4234-0266 16.654 µM 3.11300455532646 0.00329446016768303 no 65 0.000925965796416725 77 2303354
SGTC_1100 amiodarone 5.07 µM 3.10666805086005 0.00334858604504839 no 66 0.000946043654230636 48 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2688 kanamycin b 96.69 µM 3.10639766592908 0.00335091333185448 no 67 0.000946909225906791 517 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_947 3447-0010 211 µM 3.09522967372621 0.00344831915708279 no 68 0.000983302742980588 46 748350
SGTC_192 3455-0609 60.9 µM 3.07989359357405 0.00358622269400724 no 69 0.00103537280596522 48 3769639
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 3.07399411929911 0.00364057623114158 no 70 0.00105606797965965 75 23665772 A membrane-active detergent.
SGTC_691 1548-0686 185 µM 3.06939148677331 0.00368349368644356 no 71 0.0010724765582246 88 46495133
SGTC_2526 patulin 37.61 µM 3.05981398825776 0.00377425736225247 no 72 0.00110737249132032 161 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2460 5552655 174.22 µM 3.03596374947776 0.00400905425927877 no 73 0.0011988409463008 72 5401989
SGTC_1368 1852-0141 284 µM 3.00577826112089 0.00432492709432757 no 74 0.00132451047576601 81 2838987
SGTC_580 1123-0028 41 µM 3.00444523941467 0.00433937564839193 no 75 0.00133032824764262 90 1677248 YPR107C YTH1
SGTC_1119 parthenolide 318.541 nM 3.00098077972368 0.00437712871041006 no 76 0.00134555775368177 95 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3152 9099253 49.47 µM 2.98225548396851 0.00458630799020614 no 77 0.00143066555354502 210 25236131
SGTC_177 1327-0068 8.361 µM 2.98048349279882 0.00460655766763653 no 78 0.00143896874234382 94 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_204 PMA1.184 62.41 µM 2.97756356675346 0.00464009965206789 no 79 0.00145274693688482 74 2252213 YGL008C PMA1
SGTC_1122 capsaicin 818.572 nM 2.97536358908837 0.00466551517190062 no 80 0.00146320734864885 72 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1153 4055-0057 267 µM 2.97489755494415 0.0046709150056734 no 81 0.00146543204287532 77 882706
SGTC_330 1488-0319 80.1 µM 2.96435454244595 0.00479457375425626 no 82 0.00151659300796729 54 6846614
SGTC_2745 rifampicin 24.3 µM 2.93398604562997 0.00516723564434261 no 83 0.00167319626463004 14 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2611 pyromycin 23.93 µM 2.92447702645396 0.00528911094158172 no 84 0.00172517773647332 86 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1662 st014054 52 µM 2.91357498472344 0.0054319808543951 no 85 0.00178658005930938 26 2838777
SGTC_1891 st059073 26.2 µM 2.91251522791965 0.0054460501151261 no 86 0.00179265359336117 72 688754
SGTC_1134 3477-0009 42.5 µM 2.89300650675721 0.00571089633870693 no 87 0.00190786696100487 105 3973534
SGTC_3335 9143315 29.6265 µM 2.87151857129342 0.00601578771201599 no 88 0.00204252389161315 58 4899691
SGTC_2851 9015922 71.43 µM 2.87145031432434 0.00601677876503664 no 89 0.00204296504156054 102 2996893
SGTC_1902 st060212 70.5 µM 2.85819274134047 0.00621203702125847 no 90 0.00213030755003057 75 688944
SGTC_1289 0976-0073 69.1 µM 2.81019329982706 0.00696672760479048 no 91 0.00247558766906557 65 3391136
SGTC_1730 st033808 45.1 µM 2.808879628815 0.00698847392549088 no 92 0.00248571153081292 119 1045166
SGTC_582 0987-0078 156 µM 2.79713772760682 0.00718552425078435 no 93 0.00257787750828876 173 1625765
SGTC_1936 st074407 74.3 µM 2.78869080016933 0.00733029391410627 no 94 0.0026460781980351 118 809813
SGTC_2125 5246583 200 µM 2.77560810329384 0.00755959119922294 no 95 0.00275492893259441 118 835267
SGTC_3288 9119690 36.221 µM 2.75948356902755 0.00785087566729165 no 96 0.00289463991653167 67 17595618 YKL019W RAM2
SGTC_2274 7947094 46.08 µM 2.73858343276765 0.00824309492424855 no 97 0.00308522508423488 100 2971028
SGTC_1602 st001878 87.6 µM 2.7176100190179 0.00865388809467646 no 98 0.0032877645120012 75 595405 YLR310C CDC25
SGTC_2580 diallyl disulphide 81.36 µM 2.71002977242908 0.00880671526410677 no 99 0.00336385844225672 90 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_186 3455-3465 67.277 µM 2.70228236433221 0.00896535206199655 no 100 0.00344326258756951 21 755278
SGTC_2737 bleomycin 30.5 nM 2.69651747252253 0.00908501363670414 no 101 0.00350343607687429 170 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1014 4130-3005 69.3 µM 2.68928032174262 0.00923721303965952 no 102 0.00358031300016739 100 743608
SGTC_2057 5236571 38.335 µM 2.68780909711933 0.00926842482232876 no 103 0.00359612511031091 127 54684039 YBR257W POP4
SGTC_1163 k060-0048 49.9 µM 2.65717582515379 0.00993959953163432 no 104 0.00393991670417762 109 6809982
SGTC_3212 9128307 49.47 µM 2.65148776364908 0.0100687912418744 no 105 0.00400690083672487 129 27243542
SGTC_116 0155-0182 31.788 µM 2.63922734298955 0.0103522522214752 no 106 0.00415476178014886 208 771486
SGTC_3124 9127567 49.47 µM 2.63763624590973 0.0103895436866567 no 107 0.00417430405330301 77 17592030
SGTC_3308 9128332 17.569 µM 2.63757393908453 0.0103910063873878 no 108 0.00417507099241095 182 17332805 YDL196W YDL196W
SGTC_283 0987-0079 11.7 µM 2.62414504622154 0.0107104785390243 no 109 0.00434333916511069 120 411556
SGTC_2447 5741742 33.78 µM 2.61995948661209 0.0108117855375148 no 110 0.00439701067954818 114 1776504
SGTC_539 4859-0462 2.54 µM 2.61334703111812 0.0109735328795954 no 111 0.00448301051009834 104 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2204 7233102 200 µM 2.60805050430548 0.0111046058008288 no 112 0.00455297590793362 54 2172480
SGTC_938 3126-1755 342 µM 2.60797334039702 0.0111065253920019 no 113 0.00455400238253611 81 1777771
SGTC_1521 st012942 49.4 µM 2.58913870859591 0.0115837876144696 no 114 0.00481081645155624 136 24207259
SGTC_2975 9084847 53.72 µM 2.58179115712571 0.0117747445257521 no 115 0.00491445218604184 127 27211724
SGTC_2479 5617353 43.85 µM 2.5808122520007 0.0118003905681087 no 116 0.004928408571963 121 2731746
SGTC_830 4076-0286 57.8 µM 2.58017275349715 0.0118171707609716 no 117 0.00493754505082003 221 6866659
SGTC_1742 st038235 28.8875 µM 2.5797632269892 0.0118279274491794 no 118 0.00494340385621119 223 564103 YBR002C RER2
SGTC_1156 4092-0367 4.88 µM 2.57664990468191 0.0119099806104027 no 119 0.004988146851402 109 1357585
SGTC_2183 6420625 130.508 µM 2.56589451119158 0.0121972551704919 no 120 0.0051455059990327 177 2897619
SGTC_2472 5377652 49.4 µM 2.53850083984093 0.0129562063465825 no 121 0.00556642678448207 169 1610903
SGTC_1371 2421-0008 32.7 µM 2.53311182800357 0.0131102243690675 no 122 0.00565274394889627 156 2827552
SGTC_211 3455-0679 143.504 µM 2.5285191320695 0.0132427300751721 no 123 0.00572724216649145 109 748649
SGTC_141 0443-0274 32.331 µM 2.49981725866012 0.014097311156382 no 124 0.00621286920267158 190 1627241
SGTC_609 0986-0026 86.3 µM 2.48777821389686 0.0144696741453928 no 125 0.00642719339518931 145 2848610
SGTC_2233 sulbentine 40.3845 µM 2.47075564296083 0.0150106075103054 no 126 0.00674139561748867 190 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_84 0443-0269 128.823 µM 2.44539872334996 0.0158485772591686 no 127 0.00723460399429834 128 6150058
SGTC_2543 pimpinellin 60.67 µM 2.4423917198499 0.0159505611935116 no 128 0.0072951528614259 122 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_579 4491-1009 110 µM 2.43944604682963 0.0160510100656758 no 129 0.00735489952572373 160 1271041
SGTC_2842 9000675 19.48 µM 2.42812646158271 0.0164420736735348 no 130 0.00758852509394811 141 2989072
SGTC_3090 9117696 49.47 µM 2.41066696635177 0.0170612407109525 no 131 0.00796169051158046 99 7923821
SGTC_1017 4239-0030 168 µM 2.39287073516875 0.0177127509544566 no 132 0.00835856479601285 152 1149593
SGTC_1162 k048-0130 20.1 µM 2.35899839651442 0.019011564358015 no 133 0.00916216747280278 121 6797406
SGTC_519 k048-0011 62.8 µM 2.35737211415243 0.0190759094551575 no 134 0.00920239675122864 137 6836379
SGTC_629 3448-6466 76.7 µM 2.35678748173908 0.0190990860864578 no 135 0.00921689651331151 142 573744
SGTC_2909 7941780 10.49 µM 2.35433577263023 0.0191965402933298 no 136 0.00927792055863139 133 1243215
SGTC_2139 5578692 56.4705 µM 2.34980847813036 0.0193776091136603 no 137 0.00939153646249797 105 650991 YMR113W FOL3
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.34788151478758 0.0194551170078125 no 138 0.00944026312681915 158 4174840
SGTC_700 3453-2283 142 µM 2.34145053228934 0.0197156980675306 no 139 0.00960448566376506 173 565664
SGTC_1922 5578187 25 µM 2.33772111631824 0.0198681656227511 no 140 0.00970086001199476 171 1350412
SGTC_2375 9072683 200 µM 2.32807415412905 0.0202672052626695 no 141 0.0099540832213843 169 16798029
SGTC_1854 st056233 32.9 µM 2.32792762905337 0.0202733181713095 no 142 0.00995797343462583 128 5393174
SGTC_625 k213-0058 121 µM 2.32054670649116 0.0205832732104837 no 143 0.0101556606717445 315 3655420
SGTC_3139 9095020 49.47 µM 2.31301274756727 0.0209037856087217 no 144 0.010360969141823 79 25236292
SGTC_1624 st003710 6.25 µM 2.30625583757592 0.0211948241897255 no 145 0.0105481706072552 187 24207033
SGTC_2917 7979103 53.79 µM 2.30256458328956 0.0213552592255618 no 146 0.0106516768884937 183 2980565
SGTC_1188 1403-0014 4.57 µM 2.29582329418866 0.0216509101122517 no 147 0.0108429934882187 224 9614867
SGTC_550 4123-0385 25.7 µM 2.29480155935795 0.0216960204758123 no 148 0.0108722496251172 158 5731123
SGTC_2064 5220758 200 µM 2.29243990647135 0.0218005932000735 no 149 0.0109401357354001 178 788518
SGTC_653 0203-0016 55.2 µM 2.29119425873186 0.0218559210945861 no 150 0.0109760904391823 145 295302
SGTC_1484 3473-2379 286 µM 2.2906013264596 0.0218822989776393 no 151 0.0109932410769649 151 671917
SGTC_596 1155-0152 116 µM 2.2904091933029 0.0218908522045223 no 152 0.0109988035508723 204 280313
SGTC_2870 9038528 12.99 µM 2.28404399287047 0.0221758132102526 no 153 0.0111844728011086 149 6463316
SGTC_2127 5253358 187.912 µM 2.28028889909678 0.0223453868994825 no 154 0.0112952798768332 146 20612
SGTC_55 0767-0285 6.563 µM 2.26864088291474 0.0228783656529744 no 155 0.0116450866578393 192 3116166
SGTC_1824 st053723 68.6 µM 2.24454323877742 0.024015053800397 no 156 0.0123987350771725 172 675225
SGTC_784 4579-0127 173 µM 2.24038713990433 0.0242158180536205 no 157 0.0125329002194136 157 1948547
SGTC_761 k216-0224 480 µM 2.24024269314184 0.0242228209612667 no 158 0.0125375856931192 163 1340404
SGTC_120 rhodamine 6G 52.259 µM 2.23794557851925 0.0243344159152566 no 159 0.0126123021352763 213 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2313 7726885 200 µM 2.23719898979528 0.0243707783831912 no 160 0.0126366686820968 179 726423
SGTC_2967 9089538 49.85 µM 2.23283754208069 0.024584114726207 no 161 0.0127798297914284 187 728216
SGTC_2029 5175081 200 µM 2.23262165110647 0.0245947154213722 no 162 0.0127869525442295 181 1380876
SGTC_2642 cholecalciferol 100 µM 2.23227154635644 0.0246119144454523 no 163 0.0127985106267153 122 9821465 A vitamin D precursor, similar to steriods.
SGTC_2497 7-hydroxyflavone 100 µM 2.22271050246923 0.0250855198304239 no 164 0.0131176636286963 162 5281894
SGTC_2603 homopterocarpin 100 µM 2.22227647287275 0.0251071994676925 no 165 0.0131323135589229 218 101795 A weak amylase inhibitor.
SGTC_1489 4065-0444 182 µM 2.21598383347925 0.0254232830952713 no 166 0.0133463046754367 148 2877968
SGTC_1154 4088-0362 150 µM 2.21355536697121 0.0255461547544971 no 167 0.0134296902648684 211 6618304
SGTC_838 0109-0203 71.4 µM 2.2125792558079 0.0255956823731769 no 168 0.0134633332522607 144 759422
SGTC_563 tetrahydrosecaminediol 614 µM 2.20862042369219 0.0257973774236885 no 169 0.0136005267771675 167 334274 A psychoactive constituent of the cannabis plant.
SGTC_2902 5787006 60.46 µM 2.19199743101952 0.0266588620763922 no 170 0.0141898460653798 165 591003
SGTC_2243 6634756 200 µM 2.18965584574435 0.0267821237745551 no 171 0.0142746027910581 146 885676
SGTC_33 0986-0033 35.816 µM 2.18863521327959 0.0268359988838795 no 172 0.014311682145635 138 2848082
SGTC_1313 1220-0047 237 µM 2.17920777050571 0.0273379270159402 no 173 0.0146581184734172 212 3528706
SGTC_1867 st057372 64 µM 2.17795764015485 0.0274050696696897 no 174 0.0147045952850804 158 688837
SGTC_1609 st001574 46.4 µM 2.17174685188285 0.027740683777568 no 175 0.0149373812482898 168 3960012
SGTC_2239 6685329 187.64 µM 2.16327784406848 0.0282038388022223 no 176 0.0152599080596731 191 805680
SGTC_1187 1391-0724 117 µM 2.16061927415129 0.0283505520987226 no 177 0.0153623806544459 176 6997986
SGTC_2283 7944793 200 µM 2.15535747614814 0.0286427973552505 no 178 0.0155669356456126 215 2970533
SGTC_134 0269-0018 6.916 µM 2.15045403790374 0.0289173900289586 no 179 0.0157596589356317 307 4378915
SGTC_3168 9103419 49.47 µM 2.14030498352566 0.0294926914193315 no 180 0.0161650637548257 77 16649256
SGTC_317 4495-0002 170 µM 2.13872223216789 0.0295832607416754 no 181 0.0162290854861977 155 15991618
SGTC_1224 0823-0416 294 µM 2.13659498682483 0.0297053509975695 no 182 0.0163154738622219 172 3598164
SGTC_2364 9055074 200 µM 2.13143812379135 0.0300030579894363 no 183 0.0165265324601087 171 6470630
SGTC_862 0452-0056 10.2 µM 2.11596046111713 0.0309114774679991 no 184 0.0171740852413874 169 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_227 fluconazole 33.516 µM 2.11518333488964 0.0309576825499781 no 185 0.0172071623717694 257 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_187 1488-2104 32.728 µM 2.10637856960817 0.0314851850685634 no 186 0.0175857406552937 200 2852859
SGTC_2012 4023501 200 µM 2.10619920630265 0.0314960076558744 no 187 0.0175935260415562 192 3477460
SGTC_2010 4012422 159 µM 2.08770088500559 0.0326288021961222 no 188 0.0184124124848225 204 952393
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.0777318461552 0.0332530856275423 no 189 0.0188670320788678 222 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_161 4065-0411 162.148 µM 2.06534466902015 0.0340424711252478 no 190 0.0194451999420342 281 1906281 YLR208W SEC13
SGTC_401 neomycin 50 µM 2.05606704353291 0.034643736181737 no 191 0.0198880271817259 168 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1486 3970-0793 4.53 µM 2.05338264695768 0.0348193247197644 no 192 0.0200177404754232 148 2844330
SGTC_1621 st003705 32.4 µM 2.05173757938102 0.0349272905399266 no 193 0.0200975862584755 227 24207032
SGTC_3144 9087057 49.47 µM 2.04892747217016 0.0351123534716626 no 194 0.0202346037650342 187 17249618
SGTC_2154 5570129 200 µM 2.04773391511964 0.0351911996515034 no 195 0.0202930393821985 212 673366
SGTC_614 0462-0418 107 µM 2.04405964685552 0.0354348334763983 no 196 0.0204738274988962 221 5188303
SGTC_3176 9106582 49.47 µM 2.04235654986002 0.0355482308537897 no 197 0.0205580882203362 68 17018027
SGTC_3278 9139605 49.47 µM 2.04024969649224 0.0356889230359409 no 198 0.0206627311254929 199 7958859
SGTC_66 0109-0187 42.4 µM 2.03919476325689 0.0357595410093593 no 199 0.0207152966767278 217 759417
SGTC_87 0100-0052 35.5 µM 2.03073961826349 0.0363296804096017 no 200 0.0211407075657101 440 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2438 5259590 200 µM 2.02350007930802 0.0368237434774765 no 201 0.0215108077062513 199 1201127
SGTC_311 1315-0136 58 µM 2.021770245688 0.0369426058273442 no 202 0.0216000465007883 177 6759207
SGTC_2412 st077135 33.4 µM 2.01156993100844 0.0376498948510143 no 203 0.0221326458704555 239 13258915
SGTC_386 1509-0011 3.07 µM 2.00725623248215 0.0379523141388891 no 204 0.0223611934232922 353 3107280
SGTC_735 3076-0345 636 µM 2.00293862198148 0.0382569893906242 no 205 0.0225919384614139 259 2888990
SGTC_3194 9111903 49.47 µM 2.00037536972825 0.0384388086134572 no 206 0.0227298729797818 218 17087251
SGTC_2448 5185112 27.17 µM 1.99716836806187 0.0386672821759039 no 207 0.0229034480136316 186 5718189
SGTC_458 nppb 133 µM 1.99525436828924 0.0388041659674565 no 208 0.0230075720100721 175 4549 A chloride channel blocker.
SGTC_1067 clotrimazole 1.36 µM 1.9940349735165 0.0388915792438075 no 209 0.0230741163104171 246 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_413 propylparaben 100 µM 1.99370722358807 0.0389151015804274 no 210 0.0230920297528616 196 7175 A pharmaceutical preservative.
SGTC_1693 xanthone 101.9 µM 1.98777026825496 0.0393432011723102 no 211 0.0234185516954515 220 7020 An insecticide.
SGTC_2623 humulene 100 µM 1.97538963964466 0.0402482676291391 no 212 0.0241119738077594 168 6187145 An anti-inflammatory.
SGTC_1092 toremifene 6.32 µM 1.96978211567568 0.0406637248618723 no 213 0.0244316735574462 262 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3240 9133527 49.47 µM 1.9691570598327 0.0407102496075007 no 214 0.0244675290684662 196 17617455
SGTC_365 0121-0052 13.6 µM 1.96899444524207 0.040722360568323 no 215 0.0244768644788389 335 3101739
SGTC_1629 st005085 44.9 µM 1.96814413123645 0.0407857365781702 no 216 0.0245257281760163 248 24207091
SGTC_1671 st016596 74.5 µM 1.96615733335075 0.040934129527106 no 217 0.0246402196613186 237 2829167
SGTC_1363 1636-0063 10.4 µM 1.94587748592397 0.0424740055758613 no 218 0.0258347289864609 255 6072185
SGTC_892 0929-0076 29 µM 1.94525324201753 0.0425221385065506 no 219 0.0258722533488965 309 5751038
SGTC_2025 5147754 141 µM 1.94488564982514 0.0425505026874443 no 220 0.0258943712671022 185 315777 YLR208W SEC13
SGTC_1442 4112-3290 3 µM 1.93991045649852 0.0429359059100033 no 221 0.0261952865390698 242 704353
SGTC_1449 4112-4002 201 µM 1.93946455289609 0.0429705851155673 no 222 0.02622239837743 220 2059539
SGTC_1583 clindamycin 39.6 µM 1.93822011331325 0.0430674884921152 no 223 0.0262981869422828 214 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_870 0573-2213 57.6 µM 1.93267647246801 0.0435013136536092 no 224 0.0266380326425717 204 3916321
SGTC_2876 9059903 25.97 µM 1.9323631442408 0.0435259385184398 no 225 0.0266573498517036 220 6916095
SGTC_1539 benzyladenosine 56 µM 1.92996383411532 0.0437148765122409 no 226 0.0268056595194969 203 92208 A nucleotide analog.
SGTC_148 3253-0744 288.01 µM 1.92426889009612 0.0441659850910762 no 227 0.0271604439771427 232 6893655
SGTC_147 4466-0538 29.23 µM 1.92143607724963 0.0443917717915233 no 228 0.0273383769580113 270 6742687 YHR072W ERG7
SGTC_1197 1601-0112 267 µM 1.91316692605725 0.0450561809653961 no 229 0.0278633430704629 270 7350313
SGTC_2192 5915882 198.485 µM 1.90487977930467 0.0457300419931311 no 230 0.0283978501431015 188 2876149
SGTC_1319 1306-0155 43.7 µM 1.90292275136289 0.0458903523685038 no 231 0.0285253128869463 291 3122360
SGTC_2576 guaiol 23.12 µM 1.89485220372121 0.0465562297703479 no 232 0.0290559924251139 264 227829
SGTC_1051 3253-3903 78 µM 1.88772726558855 0.0471505119820751 no 233 0.0295312870189526 285 5509239
SGTC_1068 loratadine 26.9 µM 1.8876665151095 0.0471556051283356 no 234 0.0295353671808158 254 3957 A H1 histamine antagonist.
SGTC_233 rapamycin 362 pM 1.87663980049674 0.0480873825118815 no 235 0.0302837392712447 235 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2583 asiatic acid 100 µM 1.87594407794434 0.0481466629943908 no 236 0.0303314796114118 259 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3006 9075424 71.4286 µM 1.87318029525135 0.0483827345918373 no 237 0.0305217461897167 243 7465181
SGTC_1324 1418-0026 34.4 µM 1.87313114530624 0.0483869411527154 no 238 0.0305251387368997 270 1372513
SGTC_2785 7756463 72.73 µM 1.86726218701336 0.0488913499782858 no 239 0.030932491561375 261 2201551
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.86588158880431 0.0490106141220967 no 240 0.0310289670070263 297 6708561
SGTC_2944 9067346 25.62 µM 1.86487632723419 0.0490976006324747 no 241 0.0310993706703807 288 6473075
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.85374500657803 0.0500690722028585 no 242 0.031887824750969 276 94937 An inhibitor of serotonin biosynthesis.
SGTC_1882 5615643 20 µM 1.8510530681011 0.0503062941407377 no 243 0.0320809594640435 227 2253075
SGTC_1430 4049-0248 69.1 µM 1.85027958530043 0.0503746212480216 no 244 0.0321366317261119 291 22774488
SGTC_745 0469-0705 296 µM 1.84847718691622 0.0505341265660055 no 245 0.0322666708137682 302 3486736
SGTC_81 0411-0046 9.971 µM 1.84674567999781 0.0506877369305574 no 246 0.0323920039300896 232 12925265
SGTC_986 1493-0483 84 µM 1.84424106262211 0.0509105914106707 no 247 0.0325740082570826 232 40079
SGTC_1036 k216-0215 33.5 µM 1.84263893320133 0.0510535533924179 no 248 0.032690872754478 335 622330
SGTC_988 1497-1057 103 µM 1.83186588099108 0.0520231743423669 no 249 0.033485702455892 283 3533044
SGTC_2682 pyrogallin 40.03 µM 1.82543980672377 0.0526084791621209 no 250 0.0339673434374992 313 822798 An ATP competetive kinase inhibitor.
SGTC_2556 citropten 84.59 µM 1.82099961127094 0.0530159488876973 no 251 0.0343034579785064 317 2775 A potential DNA crosslinker.
SGTC_1038 k292-0204 154 µM 1.81971643721472 0.0531341687340702 no 252 0.0344010994168191 266 4454212
SGTC_2058 5236698 133 µM 1.81913847921425 0.0531874846910488 no 253 0.0344451529062111 282 766665
SGTC_59 0330-0160 1.33 µM 1.81792122746845 0.053299913481481 no 254 0.0345380866795417 470 4293482
SGTC_876 0720-0963 56.8 µM 1.81280615717695 0.0537744159938801 no 255 0.0349308619911292 280 765861
SGTC_3284 9108171 64.8615 µM 1.81004848565294 0.0540316174933231 no 256 0.0351441342736789 236 8687505
SGTC_738 1315-0003 72.4 µM 1.80623987210373 0.0543884378848482 no 257 0.0354404396670006 294 6251474
SGTC_2076 5212012 200 µM 1.80196312738364 0.0547913354582837 no 258 0.0357756035094682 180 604802
SGTC_2714 st079313 56.9 µM 1.80094658631786 0.0548874465122315 no 259 0.0358556496155175 253 2939799
SGTC_1071 trifluoperazine 6.31 µM 1.80087730057352 0.0548940021287233 no 260 0.0358611107619059 305 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1847 st056231 15 µM 1.80058509208929 0.0549216568578561 no 261 0.0358841503184548 345 5393180
SGTC_984 1492-0255 2.91 µM 1.78067984542276 0.0568315557347882 no 262 0.037482383760029 274 1585198
SGTC_2326 6164455 177.58 µM 1.76935842940531 0.0579409520824725 no 263 0.0384170391714236 285 2888790
SGTC_3310 9130229 44.1445 µM 1.76836989501892 0.0580386219662089 no 264 0.0384995430058149 285 7761258
SGTC_2828 7998861 71.43 µM 1.76830671878801 0.0580448683454828 no 265 0.0385048206478861 236 2988188
SGTC_2812 7970281 58.44 µM 1.7672802792468 0.0581464288215503 no 266 0.0385906504224545 340 2233435
SGTC_206 4546-0025 72.014 µM 1.76725299817081 0.0581491300356178 no 267 0.0385929337619338 373 6620745 YIL048W NEO1
SGTC_1354 1498-1681 81 µM 1.76587249117755 0.0582859486134485 no 268 0.0387086216294193 311 5754243
SGTC_720 r052-1644 49.9 µM 1.76407596024989 0.0584643767896724 no 269 0.038859595618531 260 1422863 YOR257W CDC31
SGTC_124 0136-0217 7.121 µM 1.76014739358367 0.0588560492272482 no 270 0.039191409416429 354 3976905
SGTC_1980 st071811 45.7 µM 1.75668856741298 0.0592025910120623 no 271 0.0394854536369669 278 4974850
SGTC_1996 st072960 66.8 µM 1.75577617986369 0.0592942698500994 no 272 0.0395633165930568 305 1719405
SGTC_1722 st034304 3.6505 µM 1.75546659812947 0.0593254026292904 no 273 0.0395897645889644 326 4036148 YLR033W RSC58
SGTC_150 3970-0969 77.2 µM 1.74949805014899 0.0599281325961012 no 274 0.0401024827755486 393 6615640
SGTC_3091 9116372 49.47 µM 1.74930182850849 0.0599480290407099 no 275 0.0401194300366769 283 17169793
SGTC_1136 pergolide 1.05886 µM 1.73980116288138 0.060917579543074 no 276 0.0409469691166239 420 47811 A dopamine receptor agonist.
SGTC_2450 5739737 12.93 µM 1.73851627800289 0.0610496389194765 no 277 0.0410599421879226 296 2262825
SGTC_3031 9088762 49.47 µM 1.73547089336999 0.0613635346710471 no 278 0.0413287163219158 317 205253
SGTC_456 gingerol 170 µM 1.73272357459893 0.061647788460612 no 279 0.0415724061480487 304 442793 A herb.
SGTC_1633 st005664 67.9 µM 1.73249001178736 0.0616720015860361 no 280 0.0415931769731491 339 2063822
SGTC_2744 captopril 92.04 µM 1.72515983378086 0.0624356905481522 no 281 0.0422493360087139 220 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2963 9082507 9 µM 1.72140123907665 0.0628301263254028 no 282 0.0425890197935445 305 16459611
SGTC_3346 9158254 43.5805 µM 1.72086176878161 0.0628868985954234 no 283 0.0426379552584201 329 17639500
SGTC_711 k292-0785 179 µM 1.71641093827645 0.0633568172190152 no 284 0.0430434279838412 313 4146315
SGTC_1164 k060-0068 93.7 µM 1.71259437724884 0.0637619426767249 no 285 0.0433935942205576 342 5963676
SGTC_2372 9071633 200 µM 1.71099602147198 0.0639322046045142 no 286 0.0435409236373752 325 21321366
SGTC_1769 st044406 64.4 µM 1.70922254758423 0.0641215342276571 no 287 0.0437048668965006 338 670903
SGTC_2390 9097792 176.6 µM 1.70883966767452 0.0641624662462915 no 288 0.0437403263256987 286 4497149
SGTC_2811 7967822 32.47 µM 1.70662066641915 0.0644000900676978 no 289 0.0439462906945135 333 2232244
SGTC_778 3456-2434 196 µM 1.70436026980436 0.0646428492296012 no 290 0.0441569007983265 411 5539063
SGTC_228 caffeine 993.056 µM 1.704148402195 0.0646656394959837 no 291 0.0441766829805512 259 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1921 5740136 50 µM 1.70200108517443 0.0648969752876621 no 292 0.0443775824206945 384 1774243
SGTC_1765 st044815 90.4 µM 1.70057146044705 0.0650513482248827 no 293 0.0445117435315414 332 645695
SGTC_2207 7258803 200 µM 1.69922176991936 0.0651973511525008 no 294 0.0446387030096427 266 3666799
SGTC_2382 9035899 200 µM 1.69797527081771 0.0653324170639517 no 295 0.0447562146392902 330 6462679
SGTC_1013 4112-3890 241 µM 1.69751291186876 0.0653825716770298 no 296 0.0447998660464419 339 705171
SGTC_3009 9080819 71.4286 µM 1.69670279808383 0.0654705211667056 no 297 0.0448764317081389 300 17027216
SGTC_2747 doxorubicin 7.63 µM 1.69384299654254 0.0657817274897839 no 298 0.0451475606525751 183 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.69137087799088 0.0660516687105297 no 299 0.0453829953530992 340 5393153
SGTC_3352 9151559 45.5865 µM 1.6909515410608 0.0660975429219346 no 300 0.0454230291126924 312 17159339
SGTC_225 nsc-122657 1.016 µM 1.68412811983293 0.0668474780631572 no 301 0.0460784554910137 196 275685
SGTC_2126 5251174 33.877 µM 1.68020745799712 0.0672813506947673 no 302 0.0464584793957132 409 790722
SGTC_327 1273-0057 3.96 µM 1.67670223462072 0.0676710899495631 no 303 0.0468003617175904 320 3108138
SGTC_933 2914-0560 114 µM 1.67648238061749 0.067695593113709 no 304 0.0468218722843556 373 463887
SGTC_100 0086-0128 49.5915 µM 1.67573685333501 0.0677787346365403 no 305 0.0468948738957202 403 93297
SGTC_800 3448-7362 155 µM 1.67446623933641 0.0679206157863449 no 306 0.0470195020476284 630 15991913
SGTC_1102 cgs 12066b 26.1 µM 1.67446321055207 0.0679209542646579 no 307 0.047019799442865 292 6438352 A 5-HT1B full agonist.
SGTC_2928 9011484 9.79 µM 1.67270759957621 0.0681173698378027 no 308 0.0471924362235477 304 2994751
SGTC_343 4130-2827 29.8 µM 1.66987697493679 0.0684349796154148 no 309 0.0474718533654994 354 1118244
SGTC_1935 st074532 41.6 µM 1.6685549163093 0.0685837118691824 no 310 0.0476028099729276 412 2829742
SGTC_886 0866-0150 153 µM 1.65975327527909 0.069580263925204 no 311 0.0484820484929352 368 271463
SGTC_2540 epiandrosterone 100 µM 1.65653891846613 0.0699469710486299 no 312 0.0488063652031885 466 441302 A steroid.
SGTC_2617 dihydrotanshinone i 20.83 µM 1.65374007481845 0.0702674843112747 no 313 0.0490901681890785 388 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2439 5492030 7.2 µM 1.64859846249297 0.070859224508792 no 314 0.0496149619676868 316 5722370
SGTC_920 mycophenolic acid 780.421 nM 1.64857196462777 0.0708622839920082 no 315 0.0496176781002998 361 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2710 st078562 53.7235 µM 1.6465946850874 0.0710908700980308 no 316 0.0498206918175325 319 17250908
SGTC_2589 lobaric acid 100 µM 1.64599440910963 0.0711603777518853 no 317 0.0498824550434208 361 73157 A novel microtubule depolymerizer.
SGTC_1335 1486-0900 202 µM 1.64349881383006 0.0714499093283406 no 318 0.0501398852832343 384 X1335
SGTC_1328 1441-0025 69.2 µM 1.64167126336206 0.0716625091428863 no 319 0.0503290750759974 304 4562601
SGTC_2959 9079155 11 µM 1.64072067840015 0.071773282834128 no 320 0.0504277052232176 300 16189457
SGTC_1848 st056003 16.4 µM 1.63984826508557 0.0718750625525429 no 321 0.0505183599648183 349 146492
SGTC_1242 0402-0103 60.1 µM 1.63927363896258 0.0719421614954349 no 322 0.0505781417513035 324 432868
SGTC_3101 9120531 49.47 µM 1.6279989594165 0.0732684404713605 no 323 0.0517625532075764 383 24824904
SGTC_3043 9092303 49.47 µM 1.62418776768051 0.0737209689892519 no 324 0.0521678703624911 340 25236084
SGTC_2052 5265182 7.135 µM 1.62203293733148 0.0739777702974307 no 325 0.0523981479422839 367 1239884
SGTC_2629 bisabolol 100 µM 1.61694526935496 0.074586803160474 no 326 0.0529450477319325 383 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2555 cholic acid 100 µM 1.61524993371975 0.07479059564849 no 327 0.0531282905129931 345 6708657 Influences liver metabolism.
SGTC_1488 4013-0813 75.9 µM 1.615205163213 0.0747959831625683 no 328 0.0531331364035671 301 2910057
SGTC_572 0960-0087 17.7 µM 1.61384188914487 0.0749601762475961 no 329 0.0532808629597553 424 6796365
SGTC_1450 4112-4260 37.6 µM 1.61321661999567 0.0750355757302477 no 330 0.053348726936579 370 1633175
SGTC_3292 9120825 59.784 µM 1.61118776093399 0.0752806286050996 no 331 0.0535694022971958 355 24824900
SGTC_2976 9009005 19.48 µM 1.61046221626526 0.0753684104368005 no 332 0.0536484938098304 358 2993148
SGTC_41 0478-0632 82.643 µM 1.60974188358176 0.0754556388427975 no 333 0.0537271086400559 425 3750424
SGTC_1138 3761-0006 1.03 µM 1.60684672181094 0.0758070035074085 no 334 0.0540439981001396 308 12061087
SGTC_72 0744-0168 198.391 µM 1.60458986654613 0.0760817648152253 no 335 0.0542920464854379 365 677577
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.60148167624297 0.0764614122602233 no 336 0.0546351376494677 391 66535 A nucleotide analog.
SGTC_2189 6047310 154.431 µM 1.60028613491141 0.0766078238919893 no 337 0.0547675606408318 348 711535
SGTC_2900 5328528 85.29 µM 1.59846610359659 0.076831122768852 no 338 0.0549696416560192 423 795359
SGTC_2336 9001819 198.65 µM 1.59632598933837 0.0770943251266304 no 339 0.0552080152573911 417 2989602
SGTC_1200 1643-0193 18.4 µM 1.59173715237677 0.077660993094302 no 340 0.0557218883739451 395 5403974
SGTC_1316 1272-0050 65.9 µM 1.58952986933748 0.0779346906510326 no 341 0.0559704080293697 348 7340392
SGTC_50 0929-0078 56.389 µM 1.58269111347229 0.0787873265348806 no 342 0.0567459423812412 379 1377751
SGTC_2234 tolnaftate 200 µM 1.58266753643871 0.0787902782263102 no 343 0.0567486306506088 276 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2459 5811157 9.22 µM 1.57803999244986 0.0793712402398739 no 344 0.0572782112349345 363 2870684 YBR192W RIM2
SGTC_1337 1486-1011 40.3 µM 1.57680188704059 0.0795272258439815 no 345 0.0574205586629745 339 X1337
SGTC_2933 9026794 32.47 µM 1.57488452827575 0.0797692463964685 no 346 0.0576415502561989 414 17586027
SGTC_956 1185-0240 191 µM 1.57454227897072 0.0798125056974443 no 347 0.0576810676038211 373 1416193
SGTC_3065 9113888 49.47 µM 1.57080883077343 0.0802855556299315 no 348 0.0581135301210654 349 16648368
SGTC_462 ag-879 158 µM 1.566095889962 0.0808857349018609 no 349 0.0586630850788166 421 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2008 4012253 172 µM 1.56123731871992 0.0815079991479563 no 350 0.0592338834054034 431 603940
SGTC_3055 9094636 49.47 µM 1.55998718509024 0.0816686931574212 no 351 0.0593814547850024 344 25236176
SGTC_3231 9132313 49.47 µM 1.55325148295967 0.0825386228352394 no 352 0.0601815330993749 380 4905967
SGTC_944 3370-0224 231 µM 1.55105508118097 0.0828237955003978 no 353 0.0604442422659442 391 4580514
SGTC_1228 0124-0032 52.5 µM 1.54945745019202 0.0830316912581537 no 354 0.060635896244383 411 X1228
SGTC_212 3807-4682 38.772 µM 1.54897863415961 0.0830940747789685 no 355 0.0606934281495717 533 3125501 YBL034C STU1
SGTC_2075 5212009 200 µM 1.54730844781931 0.0833119543268365 no 356 0.0608944428210023 339 780898
SGTC_1483 3453-0561 55.9 µM 1.5433265282707 0.0838331368077158 no 357 0.0613757850900004 435 4546991
SGTC_593 1203-0218 61.7 µM 1.54293537956294 0.0838844649810242 no 358 0.0614232277924905 380 3666956
SGTC_2771 fluoxetine 41.05 µM 1.53934401296734 0.0843568428238045 no 359 0.0618601671871297 368 3386 A selective serotonin reuptake inhibitor.
SGTC_1868 st057644 42.7 µM 1.5382611676647 0.0844996620245196 no 360 0.061992385206624 418 688665
SGTC_226 1,3-diallylurea 8.28947 mM 1.53715155336867 0.0846461999572026 no 361 0.0621281004462156 344 74537 YKL182W FAS1
SGTC_517 1365-0151 113 µM 1.53521349204078 0.0849026013400906 no 362 0.0623656976324505 395 768657
SGTC_38 0929-0051 58.268 µM 1.53516977544571 0.0849083916600342 no 363 0.0623710652415178 438 1379719
SGTC_611 3453-1652 23.7 µM 1.53465549435399 0.0849765310881488 no 364 0.0624342367301666 433 1560575
SGTC_606 k015-0008 38.6 µM 1.53341872393782 0.085140564195888 no 365 0.0625863591187364 431 1970475
SGTC_1118 chelidonine 707.474 nM 1.53329199386578 0.0851573858240815 no 366 0.0626019631851357 417 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.53090396862057 0.0854748282534311 no 367 0.0628965641328639 391 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1240 0356-0016 42.1 µM 1.52818504225473 0.0858373356916876 no 368 0.0632333007405735 406 4305613
SGTC_2800 7887935 81.82 µM 1.52698343076784 0.0859979096111279 no 369 0.0633825657910389 392 2961002
SGTC_1764 st044502 93.5 µM 1.52671470229118 0.0860338511077581 no 370 0.0634159849355327 418 8407
SGTC_2318 6029776 164 µM 1.52366031705399 0.0864431546348458 no 371 0.0637967936290034 423 818325
SGTC_2156 5649887 115 µM 1.52174729499037 0.0867002500092183 no 372 0.0640362060630919 466 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1850 st056238 17 µM 1.5206340893231 0.0868501190273001 no 373 0.0641758436071338 455 5393177
SGTC_1409 3909-8004 61.9 µM 1.51954972635967 0.0869962910186301 no 374 0.0643120906582241 428 2119279
SGTC_1254 0550-0035 264 µM 1.51898570275339 0.0870723939418047 no 375 0.064383047398227 450 15121435
SGTC_3119 9125183 49.47 µM 1.51636745161013 0.0874263221588251 no 376 0.0647132322365943 270 22695334
SGTC_967 1306-0166 352 µM 1.51444585183366 0.0876867613550596 no 377 0.0649563987237856 428 4437607
SGTC_2430 5571206 200 µM 1.51115070963642 0.0881347067782871 no 378 0.0653750286640142 472 1731771
SGTC_1332 1480-0653 17.5 µM 1.50889800297063 0.088441922624676 no 379 0.0656624251348533 428 5749438
SGTC_1849 st056239 19.2 µM 1.50859895493696 0.0884827656128892 no 380 0.0657006507060002 441 5393181
SGTC_88 0180-0332 8.668 µM 1.50812608613354 0.0885473771408117 no 381 0.0657611299789708 419 3101745
SGTC_2558 carylophyllene oxide 100 µM 1.50575146848514 0.088872370031122 no 382 0.0660654930311557 426 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_123 0083-0120 66.675 µM 1.50064706625881 0.0895739692147795 no 383 0.0667234354667217 434 16001701
SGTC_1851 st056236 18.9 µM 1.49831432644272 0.0898959717277644 no 384 0.0670258018020022 418 5393171
SGTC_520 3584-0023 682 µM 1.49330765056866 0.090589977469934 no 385 0.0676783369329337 419 1340790
SGTC_953 1188-0045 9.7 µM 1.49135369624769 0.090861903212512 no 386 0.0679343290618894 449 6144426
SGTC_914 3820-6779 408 µM 1.49027046797801 0.0910129134156372 no 387 0.0680765671306852 409 2893481
SGTC_3350 9150499 3.57 µM 1.4893474291714 0.0911417388353886 no 388 0.0681979521456858 487 4910996 YPR165W RHO1
SGTC_2728 chlorpromazine 9.18 µM 1.48559394417576 0.0916669932659493 no 389 0.0686932789108003 312 2726 A thorazine and dopamine antagonist.
SGTC_89 0302-0250 142.109 µM 1.48215043871076 0.0921508394386021 no 390 0.0691501352486901 462 4203518 YLR208W SEC13
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.48165619138827 0.0922204408874609 no 391 0.0692158996583983 457 1273210
SGTC_26 0302-0163 425.158 µM 1.48107476613598 0.0923023688085891 no 392 0.0692933256136509 400 3100915
SGTC_556 4058-0063 51.5 µM 1.47815284386766 0.0927149089966608 no 393 0.0696834362467931 464 6615692
SGTC_2727 riluzole 51.77 µM 1.47673959893881 0.0929149307288384 no 394 0.0698727265067447 375 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_464 bw-b 70c 158 µM 1.47552729721755 0.0930867662957926 no 395 0.0700354174978205 472 5353454
SGTC_2978 9011784 42.97 µM 1.4727312921222 0.093483976442108 no 396 0.0704117526791215 507 2994934
SGTC_3107 9121808 49.47 µM 1.47027651639883 0.0938337411640773 no 397 0.0707434392867772 331 662681
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.46900036598395 0.0940159525388795 no 398 0.0709163449780226 407 2346 DNA damaging agent; causes G2/M arrest.
SGTC_218 alverine citrate 93.75 µM 1.46865051322976 0.0940659508028219 no 399 0.070963803198273 393 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2495 cafestol 54.53 µM 1.45837999216074 0.0955424888330273 no 400 0.072367916213715 422 16667697 An anti-infammatory.
SGTC_58 0957-0393 9 µM 1.45557661132533 0.0959484636108656 no 401 0.0727548487517826 777 6997992
SGTC_2187 6125751 200 µM 1.45388884028169 0.0961934911050901 no 402 0.0729885636469576 462 874498
SGTC_1020 4335-0961 93.3 µM 1.45192574178398 0.0964790684240472 no 403 0.0732611270386636 415 669075
SGTC_2775 cyproheptadine 69.59 µM 1.45104209479644 0.0966078180851101 no 404 0.0733840694896594 438 2913 A selective serotonin reuptake inhibitor.
SGTC_1318 1280-3875 124 µM 1.44441950035208 0.0975767668641383 no 405 0.0743105043357119 481 373245
SGTC_1509 1326-1131 80 µM 1.44105046842231 0.0980724147149231 no 406 0.0747852126696193 396 768313
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.44067946984806 0.0981271081224233 no 407 0.0748376287678838 440 75037 A free radical scavenger.
SGTC_1778 st046819 58.9 µM 1.43583622514395 0.0988431607423062 no 408 0.0755244746014634 529 671715
SGTC_1825 st052143 62.6 µM 1.43098294362675 0.0995645250038819 no 409 0.076217551765074 401 674173
SGTC_1448 4255-0083 152 µM 1.42550686908457 0.10038306858252 no 410 0.0770053679609413 469 5399660
SGTC_14 0354-0009 295 µM 1.42318994589962 0.100730868269722 no 411 0.0773405496951875 480 1713507
SGTC_3190 9110366 49.47 µM 1.42289558837936 0.100775117925697 no 412 0.0773832126594243 385 17123768
SGTC_1272 0839-0021 27 µM 1.42270983447533 0.100803048903719 no 413 0.0774101442613941 479 5027250
SGTC_2335 9018011 154.17 µM 1.41190846992917 0.102436923051555 no 414 0.078988456743777 530 6458208
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.41093581192645 0.102584992356128 no 415 0.0791317707124923 451 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3238 9133470 49.47 µM 1.40663521477213 0.103241544120353 no 416 0.0797677926651123 446 3534688
SGTC_3213 9129884 49.47 µM 1.40565719703839 0.103391278338973 no 417 0.0799129714136981 410 17190742
SGTC_2754 granisetron 64.02 µM 1.40555565059308 0.103406834097933 no 418 0.0799280565972594 500 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2854 9024559 71.43 µM 1.40427473831446 0.103603201163839 no 419 0.0801185268449534 479 3163529
SGTC_684 1140-0066 328 µM 1.40408642064055 0.103632093535618 no 420 0.0801465583822958 525 6813534
SGTC_46 0329-0187a 2.197 µM 1.4030150368573 0.103796580324597 no 421 0.0803061775117224 588 46494817
SGTC_2674 ligustilide 100 µM 1.40025159113643 0.104221719051176 no 422 0.0807189957643805 429 5319022 A signalling regulator.
SGTC_2997 9067075 71.4286 µM 1.39793583508423 0.104578954432955 no 423 0.081066168194512 523 27209819
SGTC_3260 9137109 49.47 µM 1.39758593847027 0.104633007563491 no 424 0.081118721681225 375 17478346
SGTC_15 0266-0086 27.098 µM 1.39015298494092 0.105786058409048 no 425 0.0822412133212387 595 1712902 YIL048W NEO1
SGTC_1564 D-Arginine 115 µM 1.38738696197073 0.106217479396255 no 426 0.0826618992571919 487 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_501 nsc-95397 161 µM 1.38505032655286 0.106582917208778 no 427 0.083018539635232 455 262093
SGTC_133 0724-0033 378.92 µM 1.38484240040932 0.106615479712316 no 428 0.0830503313651679 453 280309
SGTC_1846 st056244 14.8 µM 1.38352778136018 0.106821523314268 no 429 0.0832515474855129 519 5393182
SGTC_414 piperonyl butoxide 100 µM 1.38343637501093 0.106835860340769 no 430 0.0832655517946735 458 5794 A potent inhibitor of cytochrome P450.
SGTC_538 2922-0838 53.3 µM 1.38216625750662 0.107035221143366 no 431 0.083460329022915 580 777039
SGTC_2347 9049783 174.81 µM 1.38161016079124 0.107122591875172 no 432 0.0835457162219095 531 6467988 YPL169C MEX67
SGTC_2316 5844804 197.44 µM 1.37700064275042 0.107848793599457 no 433 0.0842560245595766 611 776813
SGTC_1284 0929-0043 16 µM 1.37675423452816 0.10788771332329 no 434 0.0842941223135362 511 1239883
SGTC_2705 st078069 42.8 µM 1.37655706346718 0.107918863412922 no 435 0.0843246167044462 468 1530061
SGTC_1379 2144-0755 36.5 µM 1.37012532231853 0.108938536702564 no 436 0.085323892231765 532 5392327
SGTC_863 0466-0191 129 µM 1.36447429329165 0.109840137839426 no 437 0.0862091697517434 561 765160 YPR165W RHO1
SGTC_948 3448-0295 75.3 µM 1.36158850215423 0.110302615589718 no 438 0.0866638929301214 563 678569
SGTC_697 0508-1955 564 µM 1.35736881559193 0.110981375025653 no 439 0.0873320258355953 547 6243113
SGTC_2280 7785178 200 µM 1.35617120085612 0.111174561749057 no 440 0.0875223514236477 469 2954328
SGTC_2995 9067767 71.4286 µM 1.34371891208027 0.113197513648676 no 441 0.089519649679975 444 11673567
SGTC_1812 st052057 4.327 µM 1.34291522503518 0.113328974015562 no 442 0.0896497129547537 536 3645418
SGTC_2646 retinol 96.75 µM 1.34170282012916 0.11352749500418 no 443 0.0898461861383132 486 445354 A vitamin A analog and teratogen.
SGTC_37 0566-0070 1.56 µM 1.33940803630514 0.113903924902933 no 444 0.0902189373250453 576 1626686
SGTC_636 0kpi-0074 126 µM 1.33699439206267 0.114300811112451 no 445 0.090612233688082 480 616434
SGTC_1758 st042942 75.2445 µM 1.3273400149325 0.115898167519307 no 446 0.0921981163667641 508 669317
SGTC_2433 5607874 27.82 µM 1.32509538724512 0.116271810525659 no 447 0.0925697579397705 531 2252428
SGTC_355 1311-2252 105 µM 1.32505571440459 0.116278422185147 no 448 0.0925763364985775 540 5338538
SGTC_1534 6-azauridine 81.6 µM 1.32357867139748 0.116524768003334 no 449 0.0928215062715825 592 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1515 3460-0031 42.1 µM 1.32300587331269 0.11662040058382 no 450 0.0929167123253784 447 2876596
SGTC_940 3232-1287 54.8 µM 1.31809343074345 0.117442852584976 no 451 0.0937361866673897 544 1585493 YIL048W NEO1
SGTC_795 0685-0265 78 µM 1.31679533146572 0.11766086761829 no 452 0.0939536190786239 545 302754
SGTC_2120 5538279 151.968 µM 1.3150945620699 0.11794694418068 no 453 0.0942390619808688 524 2058197
SGTC_3306 9127676 59.7925 µM 1.3112191474311 0.118600642360125 no 454 0.0948918675907202 506 41905287
SGTC_931 2812-0076 566 µM 1.31078432112511 0.118674147527955 no 455 0.0949653205619051 566 3450959
SGTC_748 act1.228 77.9 µM 1.30730443325803 0.11926356446356 no 456 0.0955546695904193 601 4421505 YNR035C ARC35
SGTC_2882 9058044 58.44 µM 1.30633573826199 0.119428007225038 no 457 0.0957192043622818 512 18076804
SGTC_899 1083-0020 478 µM 1.30464197468521 0.119715919737878 no 458 0.0960073941574841 560 767123
SGTC_2080 5212524 12.4 µM 1.30435783188545 0.119764267339113 no 459 0.0960558028017432 518 260183
SGTC_1382 3002-2117 298 µM 1.30347532838054 0.119914515277978 no 460 0.0962062669782374 565 1497314
SGTC_793 0488-0545 106 µM 1.2977046057636 0.120900267596323 no 461 0.0971944301954116 555 292548
SGTC_891 0929-0073 133 µM 1.29766290195829 0.120907412115051 no 462 0.0972015984506516 543 5603632
SGTC_1336 1486-0901 104 µM 1.29191698969367 0.121894619218123 no 463 0.0981929466814645 541 5006114
SGTC_1296 1068-0102 11.9 µM 1.28812118667737 0.122549875077826 no 464 0.0988518906510597 551 767053
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.28612151304839 0.122896063742986 no 465 0.0992003285964309 521 6708514
SGTC_1220 1838-0075 193 µM 1.28410535799519 0.123245799349961 no 466 0.0995525467871662 565 5529645
SGTC_1414 3917-0015 5.4 µM 1.28283043465347 0.123467315619551 no 467 0.0997757444862822 509 6618702
SGTC_1432 4049-0298 68.4 µM 1.27985803714116 0.123984848434279 no 468 0.100297534026537 539 741646
SGTC_2383 9036125 200 µM 1.27799270665874 0.124310400806007 no 469 0.100625998940121 519 79580
SGTC_3230 9131665 49.47 µM 1.27768748315164 0.124363727714993 no 470 0.100679820177364 417 15943720
SGTC_3355 9151058 44.0485 µM 1.27160147688401 0.125430380899684 no 471 0.101757375879121 551 17015728
SGTC_1913 st060213 96.1 µM 1.26800609041099 0.126063512091278 no 472 0.102397887804144 617 688959
SGTC_850 0388-0143 75.9 µM 1.26524484892438 0.126551264394685 no 473 0.102891784950692 554 67273
SGTC_2844 9010103 25.97 µM 1.26514019235956 0.126569777000951 no 474 0.10291053862297 574 2480525
SGTC_261 5-fluorouridine 15.376 µM 1.26436498533802 0.126706961412104 no 475 0.103049527240925 579 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_406 estrone 100 µM 1.25535267139313 0.128309425630173 no 476 0.104675381180011 586 5870 A steroid.
SGTC_2113 5491891 107.031 µM 1.24958123430813 0.129342996074838 no 477 0.105726280857601 592 789979
SGTC_2929 9013348 24.6 µM 1.24801682074438 0.129624148321176 no 478 0.106012448651682 574 2995952
SGTC_679 0422-0091 41.4 µM 1.24659045444564 0.129880859765969 no 479 0.106273851780663 615 627384 YHR062C RPP1
SGTC_3 0833-0587 95.581 µM 1.24532266559376 0.130109326386686 no 480 0.106506583699818 576 5382644
SGTC_1331 1472-0049 76.2 µM 1.2451497893591 0.1301405017289 no 481 0.106538347610728 554 24051409
SGTC_527 4476-4215 268 µM 1.24469459354165 0.13022261341747 no 482 0.106622017028741 595 4418754
SGTC_709 3807-1509 243 µM 1.24467879464944 0.130225463985511 no 483 0.106624921870183 553 1886677 YPL242C IQG1
SGTC_1719 st032227 49.2 µM 1.24422194716903 0.130307910897248 no 484 0.106708944209105 569 3125804
SGTC_219 mitoxanthrone 164.414 µM 1.24386227056932 0.130372846856717 no 485 0.106775128714562 586 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2856 9022925 19.48 µM 1.2437145852355 0.130399516426061 no 486 0.106802313039771 602 4944862
SGTC_721 1187-1332 279 µM 1.24335152138013 0.130465095894138 no 487 0.106869163151264 493 25730
SGTC_2205 7238770 200 µM 1.24297998009767 0.130532230233396 no 488 0.106937605441353 556 279867
SGTC_2344 7990960 76.95 µM 1.23921867971467 0.131213210272268 no 489 0.107632262327798 551 140813
SGTC_1912 st060209 90.8 µM 1.23741112716914 0.131541337416877 no 490 0.107967244952466 564 688787
SGTC_2968 9090663 33.37 µM 1.23494174947928 0.131990521205223 no 491 0.1084260920153 585 25236811
SGTC_2418 pentamidine 31.67 µM 1.23355544124232 0.132243156036518 no 492 0.108684302803361 566 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_341 1486-1430 230 µM 1.2332173967052 0.132304810332933 no 493 0.108747333262848 594 2054753 YPL210C SRP72
SGTC_1904 st060225 78 µM 1.23306971619807 0.132331751278733 no 494 0.108774877439971 579 66595
SGTC_1771 st048882 4.1505 µM 1.2326078639233 0.132416030111896 no 495 0.108861050777348 598 4580403
SGTC_2340 7987427 183.45 µM 1.22102978252725 0.134540891497421 no 496 0.111037371809481 597 2239331
SGTC_704 1310-0270 142 µM 1.21203664937461 0.136207419342968 no 497 0.112749175928088 634 5718033
SGTC_1695 st026914 34.495 µM 1.21067302121365 0.136461342956548 no 498 0.113010373062499 609 3289191
SGTC_2782 7736369 71.43 µM 1.21061417949342 0.136472307260064 no 499 0.113021653653456 648 2950836 YOL077C BRX1
SGTC_507 nimesulide 162 µM 1.2087581088419 0.136818468479545 no 500 0.113377894924439 623 4495 A COX2 inhibitor.
SGTC_2932 9016711 44.54 µM 1.20740883314459 0.137070487765589 no 501 0.113637367722361 660 7117328
SGTC_2082 5219693 150 µM 1.20695861227876 0.137154651071942 no 502 0.113724041680898 629 2834649
SGTC_1431 4049-0260 9.09 µM 1.20646412927093 0.137247129317765 no 503 0.113819291021715 625 3854841
SGTC_2301 7769476 200 µM 1.20628463666448 0.137280708570338 no 504 0.11385387968262 562 977820
SGTC_274 sirtinol 40.1 µM 1.20426880828988 0.13765821259175 no 505 0.114242849227008 618 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3157 9099274 49.47 µM 1.20184743703332 0.138112598419198 no 506 0.114711321279364 580 17217662
SGTC_54 0159-0055 9 µM 1.20007008570919 0.13844677997885 no 507 0.11505606112663 608 3319099
SGTC_1338 1486-1223 76 µM 1.19659045621774 0.139102622028055 no 508 0.115733111086886 659 3444526
SGTC_1965 Pectolinarigenin 58.4 µM 1.1935714037523 0.139673365041963 no 509 0.116322832782218 628 5320438 An anti-inflammatory.
SGTC_1984 st072354 53.1 µM 1.19067354919168 0.140222691630004 no 510 0.116890882843105 631 5762938
SGTC_2359 9039622 200 µM 1.18557448329634 0.141192845583583 no 511 0.117895192040042 671 6463596
SGTC_1247 0448-0043 5.84 µM 1.1770956549661 0.14281609101306 no 512 0.119578664583887 673 3089013 YGL099W LSG1
SGTC_2839 9003951 25.97 µM 1.17606431417883 0.143014395085463 no 513 0.119784588389292 604 2990634
SGTC_101 0490-5701 117.494 µM 1.1759830145527 0.143030035116647 no 514 0.11980083179551 584 4661669
SGTC_2749 bexarotene 57.39 µM 1.17559666936542 0.143104374140525 no 515 0.119878043559626 625 82146 An retinoic acid receptor inhibitor.
SGTC_2148 5546263 113.568 µM 1.17317600379171 0.143570743169598 no 516 0.120362616388389 624 792097
SGTC_2420 aureobasidin a 50 nM 1.17231712570277 0.143736462195202 no 517 0.120534879188025 689 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2426 5582046 32.21 µM 1.1698969203256 0.144204130662543 no 518 0.121021226698219 660 2251934
SGTC_1050 3232-1156 69.3 µM 1.16833594607109 0.144506309174881 no 519 0.121335640611899 643 700529
SGTC_3044 9093193 49.47 µM 1.16317379608695 0.14550865181554 no 520 0.122379497930348 649 25236277
SGTC_871 0574-0004 149 µM 1.16227726056422 0.14568320890059 no 521 0.122561430126222 698 9551173
SGTC_755 1995-0008 37.3 µM 1.16166756443602 0.14580199822837 no 522 0.122685262919097 682 689533
SGTC_2296 7971656 126.45 µM 1.16132032542061 0.145869681165937 no 523 0.1227558283745 639 666570
SGTC_1887 st057648 70.8 µM 1.16008705016266 0.146110238665985 no 524 0.123006683023586 660 688672
SGTC_168 3970-0862 530.542 µM 1.15730915257628 0.14665305937757 no 525 0.123573037739557 809 3135186
SGTC_1908 st060353 56.5 µM 1.15681933764022 0.146748912824375 no 526 0.123673089761964 711 4227716
SGTC_1735 st034310 56.75 µM 1.14569543096721 0.14893710346361 no 527 0.12596059751769 660 871153
SGTC_2244 6635614 200 µM 1.14436827343055 0.149199617581347 no 528 0.126235469992468 524 836499
SGTC_1308 1187-1617 41.4 µM 1.13760428631718 0.150542344497009 no 529 0.127642878003534 708 2882570
SGTC_2790 5423970 71.43 µM 1.13620483911219 0.150821152191042 no 530 0.127935422881066 716 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2474 5321570 43.32 µM 1.1330456590806 0.151451809367999 no 531 0.128597539795063 653 2841384
SGTC_825 1988-2224 89.6 µM 1.13035369180832 0.151990580036005 no 532 0.129163609377128 704 1180859
SGTC_752 1896-0090 130 µM 1.12681673147934 0.152700400642239 no 533 0.129909987465455 677 772567
SGTC_781 4335-2806 94.4 µM 1.12659707781531 0.152744554594787 no 534 0.129956437596867 779 845254
SGTC_599 1935-0052 86.5 µM 1.12376755233974 0.153314092246595 no 535 0.130555825057359 710 9557311
SGTC_149 3970-0822 46.1 µM 1.12166034226054 0.153739152421781 no 536 0.131003442222708 820 3114250 YBL034C STU1
SGTC_2384 9036245 200 µM 1.12119827775671 0.15383246289434 no 537 0.131101736334052 715 6462766
SGTC_1226 3909-7979 35.4 µM 1.12105338091167 0.153861731447788 no 538 0.131132570457479 740 6615510
SGTC_3258 9138477 49.47 µM 1.12088844243348 0.153895052812058 no 539 0.131167675546965 681 4970355
SGTC_1482 3346-2049 8.48 µM 1.11790963184631 0.154497662959146 no 540 0.131802795463615 661 3826804
SGTC_1776 st049249 45.9 µM 1.11696231490289 0.154689630602389 no 541 0.132005219283473 691 1822314
SGTC_429 1112-0049 25.5 µM 1.11452274481771 0.155184718955996 no 542 0.132527496200296 652 2836170
SGTC_3032 9089427 49.47 µM 1.11358707218927 0.155374882352848 no 543 0.132728187512094 658 17173707
SGTC_1073 triclabendazole 3.09 µM 1.11274260229718 0.155546641934727 no 544 0.132909496479876 739 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_450 aminopyrene 156 nM 1.11169008492219 0.155760892272784 no 545 0.133135712176502 713 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2094 5332512 191.667 µM 1.10855415425661 0.156400395116942 no 546 0.133811282510823 725 755774
SGTC_3251 9135047 49.47 µM 1.10754755426868 0.156606034730201 no 547 0.134028632022548 662 17682963
SGTC_853 0419-0306 21 µM 1.10556249255134 0.157012086940359 no 548 0.13445796585401 656 762713
SGTC_2834 9001755 58.44 µM 1.10499093902659 0.157129128762425 no 549 0.134581757675529 637 2989575
SGTC_932 2857-0803 154 µM 1.10367662814643 0.15739848887222 no 550 0.134866718778902 754 674898
SGTC_2261 9010538 184.68 µM 1.10114253149229 0.157918692979093 no 551 0.135417314370773 603 6457250
SGTC_2960 9079389 5.97 µM 1.10093271420961 0.157961815212168 no 552 0.135462971356039 731 16457355
SGTC_2176 5809774 33.9695 µM 1.09724313082935 0.158721371885673 no 553 0.136267561717088 754 2870539
SGTC_2408 sulbentine 18.36 µM 1.09623542141476 0.158929239753684 no 554 0.136487881066793 694 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2701 st077767 14.721 µM 1.09592057475123 0.158994222124872 no 555 0.13655676711861 745 5721188
SGTC_1218 1348-1416 30.7 µM 1.09439068176807 0.159310230211684 no 556 0.136891834492427 696 6787668
SGTC_2843 9000894 45.46 µM 1.09171931568531 0.159863001445991 no 557 0.137478246232888 566 2242070
SGTC_1958 st076513 41.9 µM 1.09170503534245 0.159865959766856 no 558 0.137481385620321 698 732122 YGL099W LSG1
SGTC_433 pimozide 108 µM 1.0899131005962 0.160237461772183 no 559 0.137875712598809 577 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_328 k915-0120 63.5 µM 1.08910000735019 0.160406217366479 no 560 0.1380548933363 710 6624543
SGTC_262 fenpropimorph 62.5 µM 1.08902050796092 0.160422723508209 no 561 0.138072421074812 662 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_93 0109-0045 59.227 µM 1.08898988719225 0.160429081472564 no 562 0.138079172636236 832 88733
SGTC_1003 4049-0218 100 µM 1.08637898750249 0.160971802928962 no 563 0.138655677024049 739 295161
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.08536874079965 0.161182121660907 no 564 0.138879185713045 722 16623 A steroid.
SGTC_1591 genipin 88.4 µM 1.08532844325778 0.16119051474212 no 565 0.138888106294723 695 442424 A DNA cross-linking agent.
SGTC_2762 leflunomide 42.06 µM 1.08525843222162 0.161205097160967 no 566 0.138903605417587 743 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3056 9094900 49.47 µM 1.08491013496134 0.161277655893302 no 567 0.138980729364497 697 25236784
SGTC_2605 digitonin 300 nM 1.08482137533237 0.161296150073667 no 568 0.139000388193124 830 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_224 benfluorex 43.875 µM 1.08466312971826 0.161329125960841 no 569 0.139035441744638 648 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_454 lyso-paf C-16 6.67 µM 1.08304419564543 0.161666738841122 no 570 0.139394403315122 678 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_935 2996-0153 430 µM 1.08302213736697 0.161671342057272 no 571 0.139399298583096 726 23738523
SGTC_964 1287-0107 19.4 µM 1.08127158864305 0.162036926477734 no 572 0.139788160824766 769 51516812 YPR165W RHO1
SGTC_648 0375-0473 33.3 µM 1.07317122281959 0.163735610510704 no 573 0.141597149870384 759 1713139
SGTC_2998 9066762 71.4286 µM 1.07267701514918 0.163839620941667 no 574 0.141708028280891 763 4945196
SGTC_2847 9005661 71.43 µM 1.06473890312188 0.165516141620511 no 575 0.143497050020129 626 2991449
SGTC_2358 9037157 4 µM 1.06392915618937 0.165687780819138 no 576 0.143680396881648 741 2388925
SGTC_3193 9111931 49.47 µM 1.06271261909879 0.165945862145405 no 577 0.143956148208838 725 17087244
SGTC_1750 st081859 2.357 µM 1.06129494940667 0.166246940188421 no 578 0.144277940152595 896 5291695
SGTC_567 1080-0542 68.4 µM 1.05901524853885 0.166731831714877 no 579 0.144796417631539 685 5950415
SGTC_2868 9035608 32.47 µM 1.05593767946575 0.167387875524435 no 580 0.145498344048832 741 6462614
SGTC_2388 9080168 200 µM 1.0559266961221 0.167390219812977 no 581 0.14550085320118 686 15943073
SGTC_787 4152-0075 138 µM 1.05518992700429 0.167547524369195 no 582 0.145669235059269 724 9566539
SGTC_1834 st055981 52.8 µM 1.05457967147722 0.167677889607249 no 583 0.14580880254668 764 471719 YDL150W RPC53
SGTC_2352 9027995 87.8 µM 1.05369024680512 0.167868009034428 no 584 0.146012377861186 685 2997347
SGTC_3105 9121040 49.47 µM 1.05290537773932 0.16803589434137 no 585 0.146192180578993 517 41448907
SGTC_375 3970-0961 9.27 µM 1.04988539773038 0.168682882403231 no 586 0.146885402976049 761 2898222
SGTC_1768 st044301 37.178 µM 1.04631613044829 0.169449609005993 no 587 0.147707550233101 774 3931349
SGTC_1274 0865-0114 173 µM 1.0449589647525 0.169741732381544 no 588 0.14802096777159 752 870624
SGTC_1383 3049-0032 20.7 µM 1.04303117177174 0.170157235410609 no 589 0.148466927977544 767 712864
SGTC_2767 sibutramine 71.45 µM 1.04255077740394 0.170260877613069 no 590 0.148578198271886 778 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2751 anetholtrithion 17.25 µM 1.04121878945113 0.1705484575032 no 591 0.148887008620139 742 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_656 4090-1979 187 µM 1.04070783180269 0.170658857163558 no 592 0.149005583643368 813 22330961
SGTC_969 1313-0238 134 µM 1.03862452730553 0.171109458085659 no 593 0.149489697060207 797 5212874
SGTC_337 1315-0038 354 µM 1.03846999304729 0.171142912809972 no 594 0.149525649144821 763 1626437
SGTC_2943 9068529 45.32 µM 1.03804833088505 0.171234218644678 no 595 0.149623777351362 824 3270634
SGTC_1275 0867-0008 21.1 µM 1.03482908556291 0.171932333575889 no 596 0.150374368534299 775 3422836
SGTC_2068 5226020 147 µM 1.03480572734884 0.171937405592752 no 597 0.150379823828976 789 1810509
SGTC_1972 st070201 17.4 µM 1.03347791850533 0.172225883874813 no 598 0.150690149467644 774 2829099
SGTC_631 k072-0230 41.5 µM 1.0319484613656 0.172558554574589 no 599 0.151048130981481 810 5773147
SGTC_2163 5671233 125 µM 1.02953654337 0.173084000441661 no 600 0.151613808402154 821 701023
SGTC_3277 9138724 49.47 µM 1.02827321047175 0.173359628794929 no 601 0.151910664503113 684 15943418
SGTC_2151 5563267 85.4165 µM 1.02654396227529 0.173737361220295 no 602 0.152317626292132 798 5310824
SGTC_3323 9138564 53.9225 µM 1.02628724920337 0.173793481546573 no 603 0.152378102859794 850 43912313 YNL103W MET4
SGTC_782 0083-0095 30.5 µM 1.02356950159589 0.174388318374362 no 604 0.153019328319143 819 3591729 An indicator and reagent.
SGTC_2368 9071271 200 µM 1.02268929798689 0.174581246594817 no 605 0.153227386517118 748 27209959
SGTC_2973 9094665 17.96 µM 1.02196960920347 0.174739092906362 no 606 0.15339764224446 841 25237061 YIL048W NEO1
SGTC_2691 st077356 60.2 µM 1.01778869949218 0.17565786534335 no 607 0.154389191760675 813 2839272
SGTC_2693 st077581 40.7 µM 1.01729481552051 0.175766600206011 no 608 0.154506601101399 870 25238761
SGTC_1970 st070122 35.8 µM 1.01408005202218 0.176475413128416 no 609 0.155272277841889 764 102928
SGTC_616 4092-0450 108 µM 1.01320707764963 0.176668204184339 no 610 0.155480630273624 828 787165
SGTC_1952 st077036 64.1 µM 1.0130622931461 0.176700191827352 no 611 0.155515203755756 786 2937007
SGTC_1397 3532-0190 20.1 µM 1.01065581990855 0.177232396803133 no 612 0.156090594672607 726 5322280
SGTC_1646 st011709 75.6 µM 1.00946280879081 0.177496612808264 no 613 0.156376364675027 753 5757843
SGTC_2017 5132927 60.65 µM 1.00697980071547 0.178047321006836 no 614 0.15697224056621 783 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_532 1548-0774 215 µM 1.00689807980828 0.178065464239541 no 615 0.156991877424458 829 5932993
SGTC_2572 astragaloside iv 100 µM 1.00462319871565 0.178570988783959 no 616 0.157539161116496 777 45006101 An anti-inflammatory agent.
SGTC_3164 9100705 49.47 µM 1.0024363917226 0.17905779264862 no 617 0.158066436630087 758 17174235
SGTC_3180 9109287 49.47 µM 1.00082190731744 0.179417727340847 no 618 0.158456458151798 746 18891271
SGTC_2400 5203494 178.7 µM 0.997748419557864 0.180104189807226 no 619 0.159200683830981 736 6777674
SGTC_3330 9141424 71.43 µM 0.997541487174404 0.180150467254021 no 620 0.159250873330417 845 27261020
SGTC_2328 6201408 200 µM 0.996705700511967 0.180337454847331 no 621 0.159453690945631 765 2890418
SGTC_1238 0333-0287 48.8 µM 0.993674825817096 0.18101656278274 no 622 0.160190601240506 797 7226
SGTC_1871 st057448 67.3 µM 0.98655731934911 0.18261762469226 no 623 0.161929851187931 848 691747
SGTC_937 3122-0005 46.7 µM 0.985590768604897 0.182835727374831 no 624 0.162166984920859 860 759535
SGTC_1508 1080-0625 72.9 µM 0.985068810622576 0.182953575046477 no 625 0.162295136164883 763 767111
SGTC_2602 kawain 100 µM 0.98486986889619 0.182998504582231 no 626 0.16234399773089 873 5369129
SGTC_1375 2910-0797 186 µM 0.98475524894275 0.183024393787175 no 627 0.162372153590275 801 742508
SGTC_865 0488-0499 301 µM 0.981910395744217 0.183667692759821 no 628 0.163071996910203 886 9634651
SGTC_3004 9076122 71.4286 µM 0.981779580629828 0.183697307469783 no 629 0.163104224943147 825 44782551
SGTC_1740 st038286 13.222 µM 0.980684186217674 0.183945406169281 no 630 0.163374252288122 799 716786
SGTC_1348 1493-0373 93.8 µM 0.979453359682753 0.184224428058938 no 631 0.16367801148341 811 3010129
SGTC_1461 k072-0203 53.8 µM 0.978052937505264 0.184542216542897 no 632 0.164024071294975 792 5418714
SGTC_1252 0493-0875 34.8 µM 0.976440458064279 0.184908547765607 no 633 0.164423120291064 786 3960963
SGTC_1783 st039459 87.517 µM 0.97606817268614 0.184993189606625 no 634 0.164515341111946 879 729761
SGTC_2980 9014342 25.29 µM 0.975026896918728 0.185230059174701 no 635 0.164773459128302 766 2996599
SGTC_2345 9052315 157.45 µM 0.973924855441145 0.185480956791823 no 636 0.165046925723198 785 6469265
SGTC_2168 5727979 200 µM 0.971362698995687 0.186065088050331 no 637 0.165683848257354 753 695210
SGTC_526 4469-0568 170 µM 0.970076352716179 0.18635878422133 no 638 0.166004217559989 806 2901964
SGTC_2087 5276107 200 µM 0.968647121543366 0.186685440221267 no 639 0.166360642015085 830 144405
SGTC_478 N-arachidonylglycine 10 µM 0.968281768436409 0.186768999861113 no 640 0.166451833732771 731 5283389
SGTC_2294 7971431 200 µM 0.968236186765834 0.186779426435432 no 641 0.16646321312952 739 5741572
SGTC_2513 baicalein 25.65 µM 0.967665084112097 0.186910093784146 no 642 0.166605830629611 816 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1550 gossypolone 36.6 µM 0.966772638122223 0.187114397186833 no 643 0.166828852825197 873 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_673 1082-0474 110 µM 0.966471576603594 0.187183348908995 no 644 0.166904131503799 916 3098046
SGTC_1680 diphenhydramine 100 µM 0.964844942189805 0.187556166581867 no 645 0.167311240887264 815 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2265 7929201 200 µM 0.961497227788317 0.18832489107766 no 646 0.16815110934976 869 1265108
SGTC_2099 5377090 177.372 µM 0.960479650417768 0.188558938630376 no 647 0.168406933943192 820 2243829
SGTC_2630 antimycin a 100 µM 0.952912806289165 0.190304968300899 no 648 0.170317125477238 888 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1978 st071761 42 µM 0.952906558407428 0.190306414074671 no 649 0.170318708419837 817 5147680
SGTC_2622 2-methoxyxanthone 59.94 µM 0.952904207815113 0.190306958008723 no 650 0.170319303960552 913 71034 A hepatoprotective.
SGTC_2886 9058944 51.95 µM 0.951376616652485 0.190660649094621 no 651 0.170706613085093 706 4949929
SGTC_633 0437-0093 97.7 µM 0.950086054421428 0.190959773847213 no 652 0.171034264297036 853 2831118
SGTC_3010 9080089 71.4286 µM 0.94890434424911 0.191233921331424 no 653 0.171334632438665 868 17027233
SGTC_872 0588-0139 234 µM 0.947707249050383 0.191511883886706 no 654 0.171639254770269 869 2047100
SGTC_463 ikarugamyin 104 µM 0.946096282774212 0.191886336739595 no 655 0.172049739786908 853 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2175 5807670 165.306 µM 0.94585893971408 0.191941542593692 no 656 0.172110269311251 843 241186
SGTC_2565 isoliquiritigenin 100 µM 0.943734781195075 0.192436053321957 no 657 0.172652597810341 682 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1386 3228-0095 33.8 µM 0.94321408425057 0.192557391969395 no 658 0.172785705387894 837 870181
SGTC_258 haloperidol 50.781 µM 0.941669023919022 0.192917714452496 no 659 0.173181059422002 831 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3218 9131285 49.47 µM 0.941592453734242 0.192935582037458 no 660 0.17320066737033 937 17156417
SGTC_1002 4049-0206 172 µM 0.939398888500421 0.193447877671665 no 661 0.173762991737802 890 4662749
SGTC_848 0368-0089 85.6 µM 0.937188212576448 0.193965008139372 no 662 0.174330876005922 887 762535
SGTC_385 1494-0393 12.4 µM 0.93699825047264 0.194009484130452 no 663 0.174379728928435 886 3090647
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.934773901052796 0.194530735235195 no 664 0.174952416217312 954 551469
SGTC_477 mead ethanolamide 10 µM 0.933421891828004 0.194847979364849 no 665 0.175301090812998 745 16061185
SGTC_2553 4-methylesculetin 85.09 µM 0.931518309222984 0.195295181241293 no 666 0.175792759050083 886 5319502
SGTC_2991 9074669 71.4286 µM 0.930169497524004 0.195612429928322 no 667 0.176141666092033 904 17333109
SGTC_1690 st023502 41.2 µM 0.928610948049553 0.19597939962473 no 668 0.176545373025907 858 24207482
SGTC_2667 digitoxin 100 µM 0.928171560066016 0.196082931546694 no 669 0.176659292190861 846 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1840 st055363 71 µM 0.927570918822792 0.19622451283877 no 670 0.176815094315364 817 676033
SGTC_1193 1488-0126 41.5 µM 0.927117073928028 0.19633153285174 no 671 0.176932876087077 892 1384710
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.927105109583959 0.196334354611942 no 672 0.176935981742805 815 1241132 A phosphatase inhibitor.
SGTC_1986 st071812 45 µM 0.926155740562025 0.196558339252037 no 673 0.177182524901869 842 11838594
SGTC_3040 9091894 49.47 µM 0.92456574968452 0.196933812410891 no 674 0.177595917918727 805 25236966
SGTC_2571 chrysanthemic acid 100 µM 0.922768620184108 0.197358723275011 no 675 0.178063898527934 819 2743 An insecticide.
SGTC_564 3555-0129 330 µM 0.921232073537184 0.19772246163416 no 676 0.178464638141058 804 563260
SGTC_298 1391-0729 10 µM 0.920810978365457 0.197822215893298 no 677 0.178574561128813 875 3237558
SGTC_131 0141-0277 33.849 µM 0.920013095085071 0.198011311775088 no 678 0.17878295806864 882 1547771
SGTC_2108 5365811 200 µM 0.918757070102209 0.198309206916037 no 679 0.179111325838301 924 780283
SGTC_758 0868-0029 16 µM 0.917525363338597 0.198601596950785 no 680 0.179433704205513 920 762687
SGTC_3349 9149703 23.001 µM 0.916211606771408 0.19891375086621 no 681 0.179777959482656 911 4910494
SGTC_3199 9111318 49.47 µM 0.91352544347983 0.199552913937462 no 682 0.180483129108197 867 8548020
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.912344433317545 0.199834321890257 no 683 0.180793715400635 934 3256 An antibiotic and ribosome inhibitor.
SGTC_2792 7535235 81.82 µM 0.911394351519591 0.200060877995497 no 684 0.181043814353257 821 1281891
SGTC_1808 st050063 61.5 µM 0.91016963087499 0.200353152066185 no 685 0.181366528710851 886 4011993
SGTC_159 3970-0959 50 µM 0.907666653081234 0.200951273724444 no 686 0.182027183697245 1069 6615653
SGTC_1063 disulfiram 1.84 µM 0.907306715579216 0.20103737385712 no 687 0.182122311933397 890 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2783 7738165 71.43 µM 0.905467582257124 0.20147765558139 no 688 0.18260886322643 801 17201110
SGTC_2455 5377712 9.75 µM 0.904857017439341 0.201623950200863 no 689 0.182770570302968 810 2243908
SGTC_2477 5967686 25.23 µM 0.900770300808683 0.202604786832244 no 690 0.183855230715781 880 776118
SGTC_627 1391-0720 175 µM 0.900058164253327 0.202775995217345 no 691 0.184044649101964 878 997839
SGTC_1932 st074806 40.9 µM 0.899385208494331 0.202937863358697 no 692 0.184223757553561 981 17251235
SGTC_2235 salicylic acid 500 µM 0.897477406872327 0.203397172137526 no 693 0.184732111985592 912 338 A COX inhibitor and kinase inhibitor.
SGTC_2773 thioridazine 9.09 µM 0.897045706596227 0.203501191219508 no 694 0.184847264084858 963 5452 An antipsychotic.
SGTC_2226 7298446 200 µM 0.89627465322947 0.203687057067132 no 695 0.185053046487276 894 3283010
SGTC_2122 5258151 111.688 µM 0.895125872690645 0.20396416339326 no 696 0.185359902380162 890 2173356
SGTC_40 0327-0103 19.753 µM 0.89503852236664 0.203985243032797 no 697 0.185383247831051 874 409036
SGTC_2696 st077691 74.316 µM 0.892952642212379 0.204488999320594 no 698 0.185941267137591 833 757133
SGTC_129 0088-0017 176.636 µM 0.888210560852748 0.205637000280868 no 699 0.187213749518383 889 182446
SGTC_1995 st072814 61.1 µM 0.887603280185766 0.205784291461524 no 700 0.187377094298415 884 5769371
SGTC_1453 4237-0541 195 µM 0.886831565477367 0.205971555128445 no 701 0.187584795188611 945 739892
SGTC_2881 9058953 51.95 µM 0.886288818232236 0.206103318255039 no 702 0.187730956474561 981 17122249
SGTC_2877 9040724 71.43 µM 0.885613582537977 0.206267315444893 no 703 0.187912894935753 939 6463895
SGTC_796 1234-0020 70.7 µM 0.883213875331516 0.206850767472924 no 704 0.188560363086387 904 46495034
SGTC_1178 0988-0033 191 µM 0.881611431793078 0.207240920451298 no 705 0.188993485479994 924 5392207
SGTC_142 0335-0849 62.6745 µM 0.879574460840092 0.207737497156572 no 706 0.189544939584502 994 3889043 YPR107C YTH1
SGTC_1732 st034308 51.822 µM 0.877786506185835 0.208173946867179 no 707 0.190029794321457 877 830119
SGTC_3033 9090887 49.47 µM 0.877457578832411 0.20825429876014 no 708 0.190119075273053 956 19325384
SGTC_1717 st033143 58.0435 µM 0.876709272219423 0.208437166708836 no 709 0.190322284596578 952 674616
SGTC_677 0929-0063 136 µM 0.875945387140244 0.208623939298259 no 710 0.190529861943136 884 1539583
SGTC_1021 4476-0760 85.3 µM 0.875789842978359 0.208661982479248 no 711 0.190572146380932 902 746768
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.871002128977696 0.209834966168792 no 712 0.191876495320617 975 23847180
SGTC_1342 1486-1464 234 µM 0.870843780830116 0.209873827361665 no 713 0.191919728322864 943 3253938
SGTC_1793 st048256 72.231 µM 0.870817361771525 0.209880311437077 no 714 0.191926941966562 925 672022
SGTC_398 bronopol 33.3 µM 0.869413202158206 0.2102251061747 no 715 0.192310582271498 949 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_985 1493-0307 8.71 µM 0.868449198212798 0.21046201210967 no 716 0.192574235873867 923 3278274
SGTC_2231 micatex 6.853 µM 0.86822198632801 0.210517872705125 no 717 0.192636410135323 972 20737 An antifungal of unknown mechanism.
SGTC_297 0986-0032 24 µM 0.865084130973209 0.211290211546785 no 718 0.193496306985297 929 2847425
SGTC_3254 9136651 49.47 µM 0.864974739537048 0.211317166615445 no 719 0.193526326753706 992 16454030
SGTC_1909 st060837 51.5 µM 0.86468630972631 0.211388248064069 no 720 0.193605492785376 894 678937
SGTC_3075 9116269 49.47 µM 0.86424863579785 0.211496136393723 no 721 0.193725659928931 948 17015205 YNL244C SUI1
SGTC_2820 7989630 71.43 µM 0.862817233974252 0.211849207605002 no 722 0.194118981065492 844 2984098
SGTC_2608 thymoquinone 42.66 µM 0.861447660004065 0.212187350888953 no 723 0.194495768151175 914 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1049 3226-0134 66 µM 0.859998007838072 0.212545608716333 no 724 0.194895070328457 977 5702385
SGTC_2086 5274770 176.623 µM 0.857447176136218 0.213176862152218 no 725 0.19559889824755 938 689278
SGTC_1828 st055811 49 µM 0.856808636065941 0.213335052390067 no 726 0.195775326054862 933 5877589
SGTC_163 TUB2.036 7.546 µM 0.855874297884018 0.213566646166535 no 727 0.196033656498552 1057 15992207 YJR013W GPI14
SGTC_209 4077-0173 175.592 µM 0.85464560494876 0.213871424343447 no 728 0.196373686171352 865 15993494
SGTC_3188 9110789 49.47 µM 0.854476953491335 0.213913278217889 no 729 0.196420386825857 967 849217
SGTC_1145 3546-0597 10.2 µM 0.853536708606016 0.214146704182093 no 730 0.196680869925042 967 875334
SGTC_1230 0170-0365 3.77 µM 0.852941845984374 0.214294461781146 no 731 0.196845777195965 1088 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2803 7707263 71.43 µM 0.851407454013674 0.214675862207105 no 732 0.197271526248501 921 2199229
SGTC_2215 7188065 200 µM 0.849275912907283 0.215206348798826 no 733 0.19786389032875 965 940217
SGTC_2142 5622915 118.518 µM 0.847089473356351 0.215751287908958 no 734 0.198472626035479 947 5322196
SGTC_1291 0993-0025 5.79 µM 0.846569047547097 0.21588111442926 no 735 0.198617686246676 986 4353356
SGTC_210 3551-0445 56.827 µM 0.844817044509332 0.216318505391974 no 736 0.199106498302511 975 2865180 YOR207C RET1
SGTC_1186 1319-0216 26 µM 0.843709055537983 0.216595381585145 no 737 0.199416003014611 1032 4565136
SGTC_1353 1498-1206 8.11 µM 0.842373230460656 0.216929464335714 no 738 0.199789536134959 1009 6756808
SGTC_2528 xanthyletin 44.79 µM 0.84209042240605 0.217000231312338 no 739 0.199868670929332 971 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3315 9136395 68.55 µM 0.841239501140554 0.217213237537724 no 740 0.200106887711458 1033 16876844
SGTC_1963 st076565 50.3 µM 0.840568202626268 0.21738136502352 no 741 0.200294939187671 974 4914280
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.837700706839245 0.218100378089904 no 742 0.201099408184631 1044 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_104 0074-0074 590.992 µM 0.836503006573005 0.218401102008281 no 743 0.201435993024558 853 3943124
SGTC_1418 3966-3099 2.4 µM 0.836257407733953 0.218462797553824 no 744 0.201505054358665 999 740335
SGTC_2305 7443522 69.23 µM 0.835689906046192 0.218605394943219 no 745 0.201664687642503 1007 5415886
SGTC_1481 3346-2004 36 µM 0.834604081926848 0.218878381635071 no 746 0.201970331553812 1029 2770522
SGTC_2809 7964133 12.99 µM 0.831570987844945 0.219641969066764 no 747 0.202825571831293 971 1253665
SGTC_3178 9107506 49.47 µM 0.830384717800477 0.219941030534291 no 748 0.203160651593568 974 8897194
SGTC_247 mechlorethamine 29.705 µM 0.829792268820529 0.220090475760224 no 749 0.203328121348668 957 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2011 4012611 177 µM 0.829574867094063 0.220145329940482 no 750 0.203389595757447 1010 2049887
SGTC_1472 k841-0093 193 µM 0.827672347977353 0.220625702551356 no 751 0.203928041651332 1047 X1472
SGTC_879 0831-1030 162 µM 0.827423512257439 0.220688576184923 no 752 0.203998529236472 999 1549252
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.827151942344864 0.220757205806232 no 753 0.204075473290373 1115 688801
SGTC_2016 5121758 140 µM 0.826219215081739 0.220993012453799 no 754 0.204339875051269 1062 2795203
SGTC_3116 9124943 49.47 µM 0.825521241052406 0.221169564428862 no 755 0.204537864262078 952 41905195 YPL160W CDC60
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.824410581220416 0.221450671249627 no 756 0.204853152302183 1056 688664
SGTC_3324 9138759 60.749 µM 0.818398421841758 0.22297588338342 no 757 0.206564861292423 1018 45595710
SGTC_766 1391-0721 126 µM 0.817992429734326 0.223079093883989 no 758 0.206680754982579 1020 1020919 YIL115C NUP159
SGTC_1271 0832-2808 169 µM 0.813247922581477 0.224287247751679 no 759 0.208037964242845 1053 3663794
SGTC_3140 9094243 49.47 µM 0.812922789199023 0.224370176360517 no 760 0.208131163809589 1100 19291112
SGTC_2940 9060638 45.86 µM 0.811492340804957 0.224735233574007 no 761 0.208541494792674 982 4027022
SGTC_1300 1094-0077 113 µM 0.811136252786097 0.224826161258593 no 762 0.208643714446337 964 5532636
SGTC_2740 felodipine 17.08 µM 0.810698170787409 0.224938054856609 no 763 0.208769512038809 972 3333 L-type calcium channel blocker
SGTC_1994 st072947 40.9 µM 0.810275091803603 0.22504614638479 no 764 0.208891043851219 999 5286565 YDL195W SEC31
SGTC_903 1134-0042 114 µM 0.810061419821029 0.225100748158677 no 765 0.208952438164431 1011 701009
SGTC_231 b-estradiol 524 µM 0.809821917394274 0.225161959569467 no 766 0.209021266964437 969 450 A steroid.
SGTC_1249 0481-0015 10.2 µM 0.809420386377431 0.225264602981332 no 767 0.20913668989536 1008 4227577
SGTC_2117 5521686 200 µM 0.806530353582206 0.226004163660291 no 768 0.209968556731751 1006 803312
SGTC_2044 5102272 200 µM 0.80573383812923 0.226208233337294 no 769 0.210198167028479 974 592666
SGTC_717 1532-0246 73.2 µM 0.805350889090904 0.226306383091992 no 770 0.210308611639327 1006 9561992
SGTC_1665 st014639 11.4 µM 0.80397162738544 0.226660086846741 no 771 0.210706680579798 1094 981133 YIL048W NEO1
SGTC_292 k038-0015 474 µM 0.801398962764401 0.227320664931152 no 772 0.21145035771719 1060 46368540
SGTC_2020 4017018 200 µM 0.801193303705272 0.227373518389474 no 773 0.211509873614854 1051 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1546 5-methoxyflavanone 78.7 µM 0.800387148491321 0.22758076341725 no 774 0.211743262304851 1076 147795
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.799934053725936 0.227697290933152 no 775 0.211874503165861 1061 4213774
SGTC_1955 wogonin 32.4 µM 0.798778279183124 0.227994686626043 no 776 0.21220949370978 1016 5281703 A flavanone.
SGTC_379 3970-0972 5.9 µM 0.798318850238506 0.228112964277286 no 777 0.212342740883444 1014 2898042 YBL034C STU1
SGTC_3208 9114115 49.47 µM 0.796135313291308 0.22867557622878 no 778 0.212976695379018 963 650895
SGTC_750 4073-0104 132 µM 0.795483965286236 0.228843553857043 no 779 0.213166017335397 887 22330957
SGTC_1173 0443-0020 122 µM 0.795445970963283 0.228853354437307 no 780 0.21317706386109 1032 5331295
SGTC_664 1222-0054 14.9 µM 0.795316519032622 0.228886748142913 no 781 0.213214703413546 1060 6813991
SGTC_682 0kpi-0099 17 µM 0.794884818928345 0.228998130218169 no 782 0.213340252909531 1060 1714895 YML126C ERG13
SGTC_1997 st073024 93.8 µM 0.79287827177523 0.229516234388697 no 783 0.213924373902058 1055 686268
SGTC_115 0527-0192 112.043 µM 0.792734459709982 0.229553392853253 no 784 0.213966274405595 1084 4233931
SGTC_2201 6605497 169.863 µM 0.792047369591152 0.229730971159805 no 785 0.214166528141027 1049 670741
SGTC_1454 4239-0054 42.6 µM 0.791901530177829 0.229768673222774 no 786 0.214209047344039 1094 1340767
SGTC_1835 st008666 49.2 µM 0.791283863464702 0.229928389378172 no 787 0.214389181336202 952 690455
SGTC_3334 9142812 21.919 µM 0.787622382693532 0.230876449460748 no 788 0.215458809189631 1016 45283678
SGTC_522 1273-0010 11.6 µM 0.786765607378315 0.231098607356111 no 789 0.215709545033611 1056 5705015
SGTC_3131 9127911 49.47 µM 0.78641144056444 0.231190476019283 no 790 0.215813241572611 1032 45595681
SGTC_1491 4138-0063 26.5 µM 0.785792410964701 0.231351097359187 no 791 0.215994556678117 1048 23883227
SGTC_2895 9054447 58.44 µM 0.785199635237384 0.231504964849879 no 792 0.216168264653581 1060 2697450
SGTC_1060 3448-7350 82 µM 0.784976308292266 0.231562948879449 no 793 0.216233729723955 1033 570178
SGTC_2591 skatole 100 µM 0.784584283952037 0.231664752638599 no 794 0.216348673756689 1048 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2190 6049624 200 µM 0.784052603161054 0.231802863253873 no 795 0.216504622446881 1018 2265554
SGTC_2920 7982904 15.77 µM 0.783334123794388 0.23198956994272 no 796 0.216715464818929 1005 6456808
SGTC_727 3032-0951 202 µM 0.782754817387496 0.232140171590473 no 797 0.216885552432405 1029 3652836
SGTC_2659 sanguinarine 24.21 µM 0.780943798403565 0.232611330982731 no 798 0.217417775224571 1024 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_61 0978-8327 98.565 µM 0.780750126574142 0.232661748594188 no 799 0.217474736155045 1125 6150059 YHR072W ERG7
SGTC_1784 st039334 36.3 µM 0.779870239061771 0.232890881745188 no 800 0.217733628815119 1066 3496984
SGTC_144 4161-2749 112.381 µM 0.779700658786087 0.232935056865374 no 801 0.217783545494883 969 797501 YMR168C CEP3
SGTC_1437 4092-1038 11.6 µM 0.779220121020607 0.233060260695748 no 802 0.217925029692728 1095 3977136
SGTC_2221 6807166 181.081 µM 0.778721064133888 0.233190329219413 no 803 0.218072022544965 1026 674925
SGTC_2264 7948757 110.76 µM 0.777234729729367 0.233577949160302 no 804 0.218510147810146 1095 2971411
SGTC_2750 bromebric acid 70.15 µM 0.776268710980088 0.233830067855064 no 805 0.218795171721732 1087 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2506 ethyl hematommate 54.16 µM 0.775992080999738 0.233902292552936 no 806 0.218876830806004 1012 3940691 An allergen.
SGTC_2715 st079500 56.4 µM 0.775537660222192 0.234020963074171 no 807 0.219011010444469 1020 28246688
SGTC_1030 k029-0042 36.7 µM 0.775396351942529 0.234057872072314 no 808 0.219052745056616 1079 6080581
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.774831618195532 0.234205409815893 no 809 0.219219581673645 1187 5282309
SGTC_2986 9022445 71.43 µM 0.772741654002139 0.234751864463825 no 810 0.219837644879535 1059 6459286
SGTC_1805 st050013 60.3 µM 0.772417041035997 0.23483680292751 no 811 0.21993373203415 1038 4037144
SGTC_364 0083-0097 67.7 µM 0.772372790089697 0.234848382977653 no 812 0.219946832414583 1080 5207356
SGTC_102 gallobenzophenone 83.616 µM 0.77215411215302 0.234905613539157 no 813 0.220011578036665 1058 70837
SGTC_1064 honokiol 6.76 µM 0.771245834639569 0.235143402805049 no 814 0.220280615594989 1070 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1666 st014829 29 µM 0.770858237569516 0.235244917118031 no 815 0.220395481702076 1112 3858230
SGTC_1155 4088-0394 48.2 µM 0.769170093834117 0.235687335543664 no 816 0.220896170794077 1076 2326248
SGTC_3103 9120822 49.47 µM 0.767999655843252 0.235994345970342 no 817 0.221243694679414 1116 17141819
SGTC_2424 5537928 59.2 µM 0.7676453752871 0.236087318565695 no 818 0.221348948512176 1147 5382802
SGTC_2213 7173844 200 µM 0.76667508831341 0.236342050832842 no 819 0.221637359330703 1109 892728
SGTC_1841 st054148 70 µM 0.766573176997656 0.236368814686346 no 820 0.221667664192892 1011 675442
SGTC_1176 0848-0131 83.3 µM 0.766401413316966 0.236413926877673 no 821 0.221718746064033 1159 6769040
SGTC_661 1304-0007 33.6 µM 0.766267671163248 0.236449056337304 no 822 0.221758525133113 1065 3117130
SGTC_2085 5307070 144.047 µM 0.765874795967963 0.236552267740743 no 823 0.221875401991588 1044 2840351
SGTC_3016 9080866 49.47 µM 0.765481270012643 0.236655674951345 no 824 0.221992507705534 1116 17066299
SGTC_2996 9066192 71.4286 µM 0.763196779503334 0.237256463735418 no 825 0.222673024574328 1112 6472854
SGTC_424 splitomicin 100 mM 0.759670644636298 0.238185429598896 no 826 0.223725739986417 1020 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.759438490041016 0.238246660943704 no 827 0.223795148074533 1070 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1683 st010134 710 nM 0.759142998634482 0.238324609999473 no 828 0.22388350989696 1146 3818134
SGTC_18 0111-0177 500 nM 0.756618023667104 0.238991254222288 no 829 0.224639370027759 1207 721752
SGTC_3013 9080133 71.4286 µM 0.755657995042976 0.2392449883627 no 830 0.224927137339023 1161 17050193
SGTC_3049 9092223 49.47 µM 0.751546077505108 0.240333425488236 no 831 0.226162040582672 1051 8623917
SGTC_51 1013-0126 23.419 µM 0.751328526995677 0.240391086816458 no 832 0.226227482533786 1090 1627850
SGTC_2241 6772625 37.8075 µM 0.748456476140438 0.241153024129359 no 833 0.227092434151153 1109 2285411
SGTC_2644 guaiazulene 100 µM 0.747057737133546 0.241524575758628 no 834 0.227514354895145 1131 3515 A coloring agent.
SGTC_3126 9127922 49.47 µM 0.744644019699542 0.242166469882854 no 835 0.228243474608554 1148 45595682
SGTC_2329 6138490 200 µM 0.74414614485992 0.24229898764163 no 836 0.22839403257397 1006 720019
SGTC_254 nsc-64875 3.808 µM 0.743043966189504 0.242592490769349 no 837 0.228727531201602 1146 56993
SGTC_2053 5265679 138 µM 0.741924440780985 0.242890810203078 no 838 0.22906655834705 1127 764595
SGTC_2890 9046729 58.44 µM 0.741329518445665 0.243049419620577 no 839 0.229246833991906 1060 903329
SGTC_1944 st076371 56.9 µM 0.739566949045716 0.243519658520072 no 840 0.229781401233133 1110 24208455
SGTC_1487 3970-0795 2.82 µM 0.736633665692695 0.244303322409008 no 841 0.23067257812949 1143 3765103
SGTC_744 1594-0068 283 µM 0.735389646423859 0.244636087986748 no 842 0.231051112782008 1168 668392
SGTC_2861 9024595 19.48 µM 0.734554853254947 0.244859525514861 no 843 0.2313053209122 1079 16482810
SGTC_1298 1079-1278 263 µM 0.7334144385439 0.245164941952128 no 844 0.231652847776185 1176 2840950
SGTC_3165 9101544 49.47 µM 0.732815866505771 0.245325328507411 no 845 0.231835371366866 1126 5002184
SGTC_3002 9075603 71.4286 µM 0.730977601900216 0.245818241347446 no 846 0.232396416999076 1157 20105405
SGTC_1088 bifonazole 369 nM 0.730753666282128 0.245878323817906 no 847 0.232464814601352 1089 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2462 5162487 171.77 µM 0.730409356641719 0.24597071830426 no 848 0.232570000385765 1140 2259986
SGTC_1359 1582-0056 520 nM 0.729973939016551 0.24608758802286 no 849 0.232703057327536 1161 3661189
SGTC_2977 9011197 71.43 µM 0.728983527715256 0.246353533560395 no 850 0.23300586932701 1082 2704722
SGTC_749 1000-0129 128 µM 0.728379518254769 0.246515797951684 no 851 0.233190648774764 1184 708470
SGTC_2047 4141938 200 µM 0.728056803796872 0.246602517185809 no 852 0.233289407377933 1110 3807862
SGTC_3293 9120939 62.045 µM 0.72734411665131 0.246794087036793 no 853 0.233507589473531 1139 934087
SGTC_1205 4161-2785 76 µM 0.726843178460757 0.246928786569288 no 854 0.233661014434984 1070 3498106
SGTC_531 3788-1495 174 µM 0.726587517480595 0.246997547565908 no 855 0.233739338596971 1088 2896655
SGTC_2894 9048625 32.47 µM 0.724930749763376 0.247443389774504 no 856 0.234247257643432 1187 4092861
SGTC_1185 1319-0113 81.3 µM 0.724825660893899 0.247471684068562 no 857 0.234279495570815 1139 4672763
SGTC_1903 st060211 78.3 µM 0.724495279895421 0.247560647633231 no 858 0.234380861962706 1167 688960
SGTC_3054 9094397 49.47 µM 0.723724376903224 0.247768299481024 no 859 0.234617482199158 1160 2598354
SGTC_338 4055-0136 114 µM 0.722855973339533 0.248002325600325 no 860 0.234884187326155 1141 2900563
SGTC_3069 9117009 49.47 µM 0.717267413884575 0.249511204411567 no 861 0.236604554897864 1044 41904981
SGTC_3084 9116877 49.47 µM 0.715628113113733 0.249954729651757 no 862 0.237110504864406 1085 27241325
SGTC_288 1315-0019 35.1 µM 0.713889971751576 0.250425453576054 no 863 0.237647609431156 1184 6811474
SGTC_751 0833-0568 350 µM 0.713782718633894 0.250454515277548 no 864 0.237680773662612 1182 6954252
SGTC_3154 9100113 49.47 µM 0.712332198090179 0.250847729168896 no 865 0.238129545104891 1165 25237525
SGTC_802 4112-3352 742 µM 0.71113149739333 0.25117346778733 no 866 0.238501376645921 1200 704594
SGTC_78 0336-0123 156.75 µM 0.710844732460016 0.251251297454222 no 867 0.238590228662234 1042 6765896
SGTC_2407 paclitaxel 400 µM 0.709952026124844 0.251493664750412 no 868 0.238866943136708 1175 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3129 9127257 49.47 µM 0.707689400888208 0.252108514189501 no 869 0.239569080448654 1098 837894
SGTC_1255 0566-0045 221 µM 0.705167142553585 0.252794850249205 no 870 0.240353113225112 1172 2788469
SGTC_1057 3448-5381 134 µM 0.705075429066199 0.25281982508626 no 871 0.240381648267882 1199 5497911
SGTC_657 3534-0529 86.7 µM 0.704472711496475 0.252983985636535 no 872 0.240569219171369 1192 1049549
SGTC_3150 9097574 49.47 µM 0.703143266222198 0.253346281252499 no 873 0.240983235591107 1153 17217476
SGTC_1400 3771-8998 51.5 µM 0.703017398793292 0.253380596316484 no 874 0.241022453350541 1139 670767
SGTC_559 1550-0661 158 µM 0.701492067852952 0.253796639305312 no 875 0.241497991561352 1188 5830875
SGTC_2664 lyso-paf C-16 73.48 µM 0.701107969337001 0.253901460932538 no 876 0.241617818638204 1195 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_411 enrofloxacin 100 µM 0.69840911397053 0.254638626829596 no 877 0.242460689137524 1245 71188 A bacterial gyrase inhibitor.
SGTC_987 1497-1013 404 µM 0.697626316252924 0.254852649875878 no 878 0.242705459728431 1174 1676435
SGTC_600 1495-0418 41.6 µM 0.695919052560926 0.255319755586072 no 879 0.243239762413937 1202 5377768
SGTC_2290 7904846 200 µM 0.695752131636252 0.255365448995205 no 880 0.243292035836855 1223 2962154
SGTC_284 0988-0104 32.6 µM 0.694478337758664 0.255714281661035 no 881 0.243691140568835 1220 4666532
SGTC_1610 st001799 48.1 µM 0.692640261722656 0.256218083051795 no 882 0.244267668514683 1110 621897
SGTC_2948 9070189 9.45 µM 0.692613900956429 0.256225312081345 no 883 0.24427594213441 1115 6473636 YDL196W YDL196W
SGTC_1987 st072290 61.9 µM 0.691771013284071 0.256456516945415 no 884 0.244540571427905 1194 54697379
SGTC_2308 7584454 197.62 µM 0.691760697876757 0.256459347144256 no 885 0.244543810963876 1234 893577
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.688433603357693 0.257373037696839 no 886 0.24558988442417 1177 756377
SGTC_1948 st076329 66.6 µM 0.687877938705812 0.257525799645492 no 887 0.245764825156753 1119 24208413
SGTC_1352 1496-0991 99 µM 0.687183865485374 0.257716678666217 no 888 0.245983435205959 1208 3000039
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.686585473889485 0.257881302952115 no 889 0.246171992435622 1180 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_190 3970-0790 3.722 µM 0.686396093306864 0.257933415053794 no 890 0.246231683678432 1180 2832352
SGTC_3160 9100216 49.47 µM 0.685616393573081 0.258148023580888 no 891 0.2464775205173 1172 17191039
SGTC_95 0471-0001 561.058 µM 0.684316018880299 0.258506151184119 no 892 0.246887816908829 1154 4015405
SGTC_1502 4534-4282 27.7 µM 0.681229158338293 0.259357312339244 no 893 0.247863250322005 1204 3278949
SGTC_1656 st012921 11 µM 0.680903442294221 0.259447208627888 no 894 0.24796629490952 1162 6732821
SGTC_467 ro 31-8220 72.8 µM 0.67965898234298 0.259790822611472 no 895 0.24836020674203 1180 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3189 9110682 49.47 µM 0.678063528719162 0.260231694450403 no 896 0.248865706968217 1260 17122418
SGTC_2199 6590217 200 µM 0.675630218370622 0.260904832977662 no 897 0.249637725365651 1178 703109
SGTC_1167 k781-0610 148 µM 0.674487983203314 0.261221123640484 no 898 0.25000056150924 1256 4525169
SGTC_2899 9053889 58.44 µM 0.673357095761248 0.261534466043468 no 899 0.250360068489497 1197 6470052
SGTC_3096 9117468 49.47 µM 0.672522519036216 0.261765831371297 no 900 0.250625554497548 1143 41316311
SGTC_3024 9090631 49.47 µM 0.670260569016806 0.262393427430191 no 901 0.251345849322786 1193 25236383
SGTC_2263 7948595 193.29 µM 0.669721373789843 0.262543145086303 no 902 0.251517711904974 1234 2971371
SGTC_279 1273-0055 2.93 µM 0.668380421937669 0.262915674980881 no 903 0.25194539472736 1280 2847562
SGTC_2860 9025725 38.96 µM 0.667362309179855 0.263198697310197 no 904 0.252270367472414 1203 40546248
SGTC_3071 9117417 49.47 µM 0.664770008553541 0.263920025702071 no 905 0.253098804047596 1173 45595590 YGL055W OLE1
SGTC_1104 tacrolimus 29.8 µM 0.663744721310125 0.264205597920824 no 906 0.253426855547736 1292 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2140 5586273 200 µM 0.663665718880489 0.264227608916207 no 907 0.253452142480327 1237 854421
SGTC_1459 k035-0031 35.7 µM 0.662332407415475 0.264599225813422 no 908 0.253879105966235 1141 3877128 YMR208W ERG12
SGTC_665 3914-0008 307 µM 0.662014538291025 0.264687860652301 no 909 0.253980952218979 1228 1069549
SGTC_1065 prochlorperazine maleate 2.48 µM 0.661656819475238 0.264787625260357 no 910 0.254095592069303 1284 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_997 3996-0078 137 µM 0.660781286286434 0.265031884340471 no 911 0.254376292829135 1287 735687
SGTC_1947 st076332 61.6 µM 0.660336415499937 0.265156039676254 no 912 0.25451898309911 1235 24208416
SGTC_2491 paeonol 100 µM 0.657519210248312 0.265942955537336 no 913 0.255423561496027 1199 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1655 st012546 55.1 µM 0.656933432747557 0.266106726302369 no 914 0.255611859957643 1227 720985 YLR208W SEC13
SGTC_3257 9139206 32.98 µM 0.654027907339433 0.266919802780032 no 915 0.256546913066029 1235 4910041
SGTC_3183 9108214 49.47 µM 0.65393445589976 0.266945974861771 no 916 0.256577017055791 1183 4974831
SGTC_3226 9131256 49.47 µM 0.653627986234334 0.267031814085767 no 917 0.25667575460399 1170 17178073
SGTC_980 1473-0395 201 µM 0.653236585271608 0.267141462018824 no 918 0.256801883844774 1208 768876
SGTC_1898 st060199 18.6 µM 0.652506848750103 0.267345952697275 no 919 0.257037128075505 1277 688866
SGTC_2982 9019404 25.97 µM 0.652222360277006 0.267425694970769 no 920 0.257128868618926 1140 22333232
SGTC_1266 0828-0227 32.9 µM 0.652169835114646 0.267440419114132 no 921 0.257145808555238 1235 3913820
SGTC_536 3852-0578 10.6 µM 0.652013813807264 0.267484158278951 no 922 0.257196130546126 1280 2869208
SGTC_356 1634-0012 32.5 µM 0.651384041558244 0.26766074590279 no 923 0.257399304790116 1267 735457
SGTC_732 3970-1727 52.7 µM 0.649973279264568 0.268056535619189 no 924 0.257854740939784 1280 1275699
SGTC_1775 st081588 35.1725 µM 0.648006139156592 0.268608908655717 no 925 0.25849048979096 1290 1426443 YGL099W LSG1
SGTC_1900 st060200 72.8 µM 0.647752135526107 0.268680274565402 no 926 0.258572638927783 1266 688945
SGTC_1372 2752-0194 270 µM 0.647568347546942 0.268731918335416 no 927 0.258632087545865 1238 823334
SGTC_2331 7980721 200 µM 0.646841246788161 0.268936279946204 no 928 0.258867347124032 1256 2981221
SGTC_1857 st056007 79.3 µM 0.646278829854476 0.269094408415827 no 929 0.259049397778076 1277 619834
SGTC_3235 9132602 49.47 µM 0.644958727715126 0.269465749932445 no 930 0.259476966065195 1306 4912240
SGTC_654 1124-0271 80.9 µM 0.643441323260649 0.269892909180325 no 931 0.259968888540102 1271 5403748
SGTC_3062 9077494 49.47 µM 0.64207794022266 0.27027699927734 no 932 0.26041128916695 1265 16459633
SGTC_2149 5554786 194.827 µM 0.636291251148541 0.2719102516618 no 933 0.26229330313061 1307 745063 YPR165W RHO1
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.635030237802819 0.272266814252699 no 934 0.262704347044662 1299 2724 A muscle relaxant with antifungal properties.
SGTC_2257 7960413 200 µM 0.634546845020234 0.27240355938057 no 935 0.262862002620285 1272 2974689 YIL048W NEO1
SGTC_3314 9135860 59.4275 µM 0.633977925181128 0.272564542616986 no 936 0.263047614275533 1282 25252478
SGTC_1523 st012844 44.7 µM 0.632272725362957 0.273047333736442 no 937 0.263604341353258 1320 4274103
SGTC_1006 4099-6547 255 µM 0.632162465983541 0.27307856592331 no 938 0.26364036038676 1314 3146833
SGTC_2210 7115885 190.385 µM 0.627093927742637 0.274516193961658 no 939 0.265298833633389 1309 2927039
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.62625349523181 0.274754932663216 no 940 0.265574342037138 1325 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_85 0868-0259 160.055 µM 0.618179034625079 0.277053818533406 no 941 0.268228664238606 1299 83173
SGTC_3202 9113761 49.47 µM 0.617010137648231 0.277387394521651 no 942 0.268614019522266 1388 4798415
SGTC_1429 4049-0205 9.46 µM 0.614487001546552 0.278108107532067 no 943 0.269446779986771 1342 22774478
SGTC_1473 k844-0725 134 µM 0.614206228779136 0.278188364398463 no 944 0.269539528926347 1368 54682906
SGTC_3114 9122766 49.47 µM 0.613300276392598 0.278447401330036 no 945 0.269838905333699 1255 17176985
SGTC_3058 9093861 49.47 µM 0.611387338869835 0.278994749029698 no 946 0.270471591310425 1344 17217477
SGTC_1881 5652484 16 µM 0.610929211548076 0.279125910363028 no 947 0.270623222529598 1309 2255129
SGTC_996 3970-0799 1.8 µM 0.61068889071003 0.279194725932419 no 948 0.270702781019453 1421 6615648 YGL040C HEM2
SGTC_1638 st008370 60.6 µM 0.610507881427776 0.279246563156733 no 949 0.270762712060449 1308 24207134
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.609975146980964 0.2793991541533 no 950 0.270939135530154 1321 521171
SGTC_3133 9127736 49.47 µM 0.607918627363192 0.279988582230308 no 951 0.271620722274343 1344 27243420
SGTC_3012 9080433 71.4286 µM 0.607652334456825 0.280064949667145 no 952 0.271709041403664 1333 17688859
SGTC_855 0428-0020 25 µM 0.607415667105504 0.280132829564628 no 953 0.271787546870103 1309 6812414
SGTC_2676 harmalol 100 µM 0.60687356439987 0.280288343137391 no 954 0.271967411523796 1367 5459187 A monoamine oxidase inhibitor
SGTC_2514 salinomycin 42.74 µM 0.60646997187331 0.280404149296743 no 955 0.272101358218051 1378 23682228 A polyether potassium ionophore.
SGTC_2173 5763948 167 µM 0.606254384260436 0.280466019133956 no 956 0.272172922157152 1334 2867177
SGTC_906 1165-0455 526 µM 0.605039385732163 0.280814825761835 no 957 0.27257641368776 1297 3252859
SGTC_584 0986-0246 15.4 µM 0.603654924980868 0.281212537773482 no 958 0.273036543968124 1398 53315 YDR232W HEM1
SGTC_3047 9092122 49.47 µM 0.600853542880685 0.28201811771476 no 959 0.273968769114478 1299 17173831
SGTC_2132 5317594 122.667 µM 0.599142168560033 0.282510795635778 no 960 0.27453904183203 1370 794577
SGTC_3041 9091929 49.47 µM 0.597904629214568 0.282867321512196 no 961 0.274951785435192 1378 25236887
SGTC_1160 4092-0570 10.5 µM 0.597051091126538 0.283113345329608 no 962 0.275236635147945 1329 4994975
SGTC_1309 pyrazolanthrone 13.4 µM 0.596562053535796 0.283254351778756 no 963 0.275399906210029 1396 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_465 cgp-37157 41 µM 0.594533751407223 0.283839540728056 no 964 0.276077587454376 1290 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_399 oxolinic acid 75 µM 0.591463432864523 0.284726463175191 no 965 0.27710497463661 1322 4628 A DNA gyrase inhibitor.
SGTC_3327 9140648 26.9345 µM 0.589947874636505 0.285164749334618 no 966 0.277612798132015 1362 8029710
SGTC_1981 st071826 47 µM 0.587998676200161 0.285728912701158 no 967 0.278266590690702 1321 11838600
SGTC_645 0845-0943 5.41 µM 0.587677717815181 0.285821859702455 no 968 0.278374317239849 1331 1885106
SGTC_1499 4480-0877 67.3 µM 0.587066291603148 0.285998963655942 no 969 0.278579592703305 1313 2861909
SGTC_3195 9113082 49.47 µM 0.586895855252611 0.286048341051601 no 970 0.27863682681003 1337 17018038
SGTC_1700 st030840 7.9285 µM 0.586858508668473 0.286059161333021 no 971 0.27864936890401 1428 5499307
SGTC_2245 6637752 200 µM 0.583229651089513 0.287111462601578 no 972 0.279869356510905 1366 681890
SGTC_1870 st057514 26.5 µM 0.582026630215951 0.287460720383489 no 973 0.28027437176017 1357 5393161
SGTC_851 0394-0702 453 µM 0.580503391072251 0.287903231117225 no 974 0.280787600308115 1370 762646
SGTC_2116 5511452 16.8835 µM 0.58031492353544 0.287958004498378 no 975 0.280851132697468 1376 870744
SGTC_188 3229-0966 278.469 µM 0.580019497960298 0.288043872460008 no 976 0.280950734614581 1469 5722370
SGTC_2938 9059746 27.26 µM 0.579559271864784 0.288177665170734 no 977 0.281105932576582 1379 6471769
SGTC_13 0199-0087 65 µM 0.578760371339606 0.288409983799308 no 978 0.281375437009396 1387 4589825
SGTC_25 0118-0223 35.662 µM 0.578320597609303 0.288537906759427 no 979 0.281523845309632 1405 5333628
SGTC_2994 9053520 71.4286 µM 0.578240940436274 0.288561080583188 no 980 0.281550730866738 1417 4647384
SGTC_1357 1503-1303 39.5 µM 0.576902143871619 0.288950693747123 no 981 0.282002781130752 1380 292895
SGTC_680 0417-1641 114 µM 0.57522840429448 0.28943812903584 no 982 0.282568417524864 1354 2835990
SGTC_1133 3473-0247 50 µM 0.575211265592414 0.289443122256433 no 983 0.282574212329261 1333 711311
SGTC_885 0865-0106 16.8 µM 0.574629503051569 0.2896126380044 no 984 0.282770947220416 1319 2793380
SGTC_1763 st044482 94.5 µM 0.574429262974496 0.289670995350121 no 985 0.282838677713391 1408 88505
SGTC_815 1582-0027 36.9 µM 0.574346857153172 0.289695013049519 no 986 0.282866553451994 1411 3128206
SGTC_813 k007-0158 173 µM 0.571810798172906 0.290434620079023 no 987 0.283725080501709 1421 6523916
SGTC_929 2805-0021 398 µM 0.571743247181723 0.290454332484971 no 988 0.283747965457046 1429 3098024
SGTC_698 k064-0052 127 µM 0.570824437805206 0.29072251719644 no 989 0.2840593278563 1441 5088751
SGTC_2598 perillyl alcohol 100 µM 0.569550089511805 0.29109466919496 no 990 0.284491444192087 1445 10819 An apoptosis inducer.
SGTC_2829 7992743 58.44 µM 0.568543467174322 0.291388793529751 no 991 0.284832999665202 1404 16462845
SGTC_2508 celastrol 40.54 µM 0.568049758086698 0.29153310073466 no 992 0.285000590816856 1332 122724 Celastrol is a natural product and antioxidant.
SGTC_2150 5556613 200 µM 0.56779490339006 0.291607605757744 no 993 0.285087120468064 1412 743190
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.567308792148991 0.291749741655324 no 994 0.285252202315993 1295 88881 An O-methylated flavonoid and antioxidant.
SGTC_1012 4112-3522 18 µM 0.56698456168683 0.291844562566051 no 995 0.285362335274894 1395 3112398
SGTC_2626 ethyl orsellinate 100 µM 0.563842745575055 0.292764126560959 no 996 0.286430578976362 1351 75653 A natural product.
SGTC_901 1112-0062 60.1 µM 0.561517038302938 0.293445692715028 no 997 0.287222559228398 1401 1908457
SGTC_856 0433-0016 11.3 µM 0.560578881814517 0.293720834485226 no 998 0.287542325651678 1403 3911780
SGTC_98 0074-0023 107.663 µM 0.559860852055036 0.29393149828988 no 999 0.287787176518495 1338 3563821
SGTC_2922 7999257 32.47 µM 0.559445882084665 0.29405327878886 no 1000 0.287928727744568 1380 2988377
SGTC_874 0599-0792 117 µM 0.558221669183089 0.294412682194791 no 1001 0.288346512857565 1426 765305
SGTC_1041 0206-0046 107 µM 0.557743331829376 0.294553167156135 no 1002 0.288509831878107 1423 50494
SGTC_2531 methyl deoxycholate 70.07 µM 0.557459200496214 0.294636629554306 no 1003 0.288606863648087 1372 16667744 Haematoxylin.
SGTC_675 1309-0189 238 µM 0.557323009321975 0.294676639013044 no 1004 0.2886533788246 1360 4246530
SGTC_1804 st050076 49.1 µM 0.555818024044595 0.295118931666761 no 1005 0.289167631343281 1420 3895976
SGTC_404 fumagillin 50 µM 0.554707678656698 0.295445441405551 no 1006 0.289547311581608 1409 12015870 A methionine aminopeptidase binder.
SGTC_333 3486-0131 40.1 µM 0.553266050575734 0.295869616341024 no 1007 0.290040622207969 1485 6744690
SGTC_2109 5483026 200 µM 0.553096681527872 0.295919468703499 no 1008 0.290098604444871 1445 759335
SGTC_3332 9141069 11.198 µM 0.552462883819528 0.296106055971591 no 1009 0.290315628574242 1365 17332883
SGTC_603 3794-0023 45.9 µM 0.548612152270647 0.29724085310086 no 1010 0.291635822183835 1463 3802260
SGTC_1362 1611-0397 101 µM 0.545108516428946 0.298275085911036 no 1011 0.292839442851124 1405 27816
SGTC_1681 tripelennamine 100 µM 0.545097194633971 0.298278430628521 no 1012 0.292843336016438 1387 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1248 0469-0687 58.6 µM 0.54346645540182 0.298760366597823 no 1013 0.29340434041381 1475 4017482
SGTC_3290 9121031 71.43 µM 0.542649876110014 0.299001824989163 no 1014 0.293685445727526 1383 17014854
SGTC_336 4111-0029 111 µM 0.540594862470065 0.299609873970976 no 1015 0.294393429881003 1376 3131175
SGTC_552 k242-0005 476 µM 0.539901456067113 0.299815169302325 no 1016 0.294632496841745 1426 4088318
SGTC_3109 9122853 49.47 µM 0.537829554263155 0.300428971915291 no 1017 0.295347363142948 1509 1234709
SGTC_965 1291-5240 308 µM 0.536407290930401 0.300850646911038 no 1018 0.29583854679021 1501 2834598
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.534317500886274 0.301470715141751 no 1019 0.296560943012039 1447 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3270 9137563 49.47 µM 0.533477093138158 0.301720237238059 no 1020 0.296851681870993 1466 17015724
SGTC_220 paclitaxel 373.376 µM 0.530753728875853 0.302529457633624 no 1021 0.297794724131039 1468 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1519 esterone 74 µM 0.530716152384047 0.302540629913379 no 1022 0.297807745611215 1374 698 A steroid.
SGTC_2423 st077119 87.2 µM 0.527119269420223 0.303610913601747 no 1023 0.299055383073901 1385 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3269 9137823 49.47 µM 0.526384810199617 0.303829665971088 no 1024 0.299310433702499 1394 17682936
SGTC_1339 1486-1321 22.7 µM 0.525242122310009 0.304170145454425 no 1025 0.299707443155238 1444 3469382
SGTC_671 0560-0003 407 µM 0.525141850181113 0.304200031017862 no 1026 0.299742292555719 1473 3238678
SGTC_2317 5986382 200 µM 0.523566726470652 0.304669659634571 no 1027 0.300289964670125 1570 877883
SGTC_1957 st077035 62.4 µM 0.523212443877696 0.304775334621394 no 1028 0.300413211367192 1497 705593
SGTC_3027 9089541 49.47 µM 0.521723139369113 0.305219740670978 no 1029 0.300931555629296 1433 9943819
SGTC_378 3970-0959 8.33 µM 0.521360233959392 0.305328074615277 no 1030 0.301057923949419 1453 6615653
SGTC_1201 1889-3372 45.9 µM 0.521169092768683 0.30538514063564 no 1031 0.301124491379119 1432 5392199
SGTC_2278 7948257 134.34 µM 0.517344983682046 0.306527837152293 no 1032 0.302457678767185 1474 1247028
SGTC_2669 eugenol 100 µM 0.516683670898679 0.306725637868217 no 1033 0.302688498371398 1484 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_409 arachidonic acid 100 µM 0.514612251972943 0.307345569868909 no 1034 0.303412000905254 1469 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_428 3448-4153 16.5 µM 0.512315872365734 0.308033471717605 no 1035 0.304214979222465 1391 3834874
SGTC_1975 st070967 30.8 µM 0.508719171468632 0.309112252920358 no 1036 0.305474541177769 1538 261391
SGTC_291 SEC14.278 35.5 µM 0.506355579213395 0.309822078185259 no 1037 0.306303526196174 1544 1068044
SGTC_3151 9099821 49.47 µM 0.505986151422648 0.309933087563041 no 1038 0.30643318576148 1433 17174189
SGTC_2327 6189656 200 µM 0.505617263063983 0.310043952139929 no 1039 0.306562680185995 1592 5349088
SGTC_630 4356-0227 183 µM 0.505023946851599 0.310222301803782 no 1040 0.306771008339513 1490 779312
SGTC_1562 morin hydrate 59.1 µM 0.501735585832648 0.311211585041448 no 1041 0.307926764490497 1501 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1168 k815-0004 80.5 µM 0.501425345176511 0.311304989626768 no 1042 0.30803590305278 1438 642433
SGTC_495 decylubiquinone 155 µM 0.500856742339594 0.31147621121011 no 1043 0.308235974086551 1427 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1649 st011737 51.3 µM 0.500638125240274 0.311542053545574 no 1044 0.308312912806772 1450 1761035
SGTC_2401 5128683 200 µM 0.499852559463677 0.311778697233201 no 1045 0.308589449339807 1396 708373
SGTC_1588 farnesol 29.9 µM 0.499847845229226 0.311780117583051 no 1046 0.308591109182596 1465 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2699 st077704 54.6 µM 0.497725525133636 0.312419834648244 no 1047 0.309338757273922 1513 645852
SGTC_2532 xanthone 78.9 µM 0.49668851951737 0.312732618350538 no 1048 0.309704359762224 1539 7020 An insecticide.
SGTC_208 k072-0098 12.366 µM 0.496308876639343 0.312847160736944 no 1049 0.309838252230179 1491 5948901
SGTC_21 0849-0113 22.993 µM 0.495206661622586 0.313179813363377 no 1050 0.310227124382176 1460 1560156
SGTC_1183 1254-0324 198 µM 0.494837496759554 0.313291262718451 no 1051 0.310357416808902 1561 5799357
SGTC_2480 5767542 37.17 µM 0.493118571043894 0.313810423773467 no 1052 0.31096440480525 1552 2867358
SGTC_760 0568-0725 82.9 µM 0.492065282506207 0.314128727120097 no 1053 0.311336597053861 1597 3916171
SGTC_2518 prenyletin 46.28 µM 0.49131052193781 0.314356900521853 no 1054 0.311603419521811 1460 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3328 9140624 29.0385 µM 0.491055443929804 0.314434029785253 no 1055 0.311693616914026 1600 4904392
SGTC_3155 9099265 49.47 µM 0.490465751627978 0.314612369119117 no 1056 0.311902179538256 1521 25236499
SGTC_56 0957-0365 83.25 µM 0.489890191585428 0.314786476183395 no 1057 0.312105802038018 1455 6752360
SGTC_64 000l-0018 272.079 µM 0.488789693358718 0.315119491803533 no 1058 0.312495297778108 1505 6811119
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.488411857659741 0.315233861230614 no 1059 0.31262907227799 1570 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.487923657924207 0.315381663656105 no 1060 0.312801958239583 1481 4620898
SGTC_2310 7668677 200 µM 0.487043013587449 0.31564835336086 no 1061 0.313113924574552 1541 2197143
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.484083223928939 0.316545383618118 no 1062 0.314163403333842 1505 97141
SGTC_2707 st078556 66.6 µM 0.482840513644503 0.316922336971536 no 1063 0.314604491030741 1579 17250899
SGTC_1748 st037455 53.6035 µM 0.481465935240488 0.317339511549228 no 1064 0.315092692363682 1549 580690
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.480328519787565 0.317684884457236 no 1065 0.315496906256127 1506 6708784 An antioxidant flavonoid
SGTC_2848 9016370 25.97 µM 0.477592100619725 0.318516439996967 no 1066 0.316470277162826 1591 7894410
SGTC_3263 9137018 49.47 µM 0.475913680108531 0.319026939119576 no 1067 0.317067937846983 1440 43844957
SGTC_2032 5185112 25.99 µM 0.475486748314056 0.319156847169014 no 1068 0.317220038179065 1524 5718189
SGTC_2934 9036370 36.88 µM 0.474814657629863 0.319361397878377 no 1069 0.317459542302869 1625 6462800
SGTC_1513 0337-0559 19 µM 0.474622160659981 0.319419994438296 no 1070 0.317528154004256 1458 775073
SGTC_2594 a-mangostin 100 µM 0.474438892341629 0.319475785964353 no 1071 0.317593482162372 1628 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.473622121210531 0.319724481498105 no 1072 0.317884698933228 1549 7104
SGTC_549 1661-1316 519 µM 0.473322593923696 0.319815703745342 no 1073 0.317991522540991 1619 2857282
SGTC_1668 st014914 51.6 µM 0.471483655870945 0.320375998464581 no 1074 0.318647694272077 1517 2839556
SGTC_909 3448-9333 149 µM 0.47144169644108 0.320388787610458 no 1075 0.31866267292629 1483 3344074
SGTC_2218 6965428 192.983 µM 0.470176122206484 0.320774632159839 no 1076 0.319114596074303 1574 675684
SGTC_977 1348-1378 135 µM 0.469942461582935 0.320845891117108 no 1077 0.31919806324022 1485 X977
SGTC_1120 ficusin 1.78878 µM 0.469570182368307 0.320959437911029 no 1078 0.319331066030954 1632 6199 A DNA cross-linker.
SGTC_1617 st002906 78 µM 0.46943125169601 0.321001816667155 no 1079 0.319380707226917 1511 5150859
SGTC_1802 st050112 57.9 µM 0.469352130999297 0.321025952312968 no 1080 0.319408979220248 1516 4662563
SGTC_2121 5257820 149.641 µM 0.468930755169539 0.321154505092037 no 1081 0.319559566034526 1602 791256
SGTC_1999 st074831 12.5 µM 0.467527328616198 0.321582815115359 no 1082 0.320061322186304 1489 17112523
SGTC_2680 butyl paraben 22.24 µM 0.466837301421882 0.321793490714721 no 1083 0.32030814304435 1544 7184 An antifungal and steroid mimetic.
SGTC_2153 5569715 200 µM 0.466484306204128 0.321901287583002 no 1084 0.320434439228868 1551 2054701
SGTC_6 0844-0013 19.835 µM 0.465904518445938 0.322078374362061 no 1085 0.320641923377207 1585 1584900
SGTC_2262 9014885 67.46 µM 0.46463953552468 0.322464883104244 no 1086 0.321094807496336 1540 6457424
SGTC_1688 st021091 57.6 µM 0.464113465526205 0.322625677511012 no 1087 0.321283227394183 1633 3656366
SGTC_182 3448-4371 550.524 µM 0.463494232474328 0.322814989911573 no 1088 0.321505073993351 1656 3491403
SGTC_1441 4106-0040 13 µM 0.462552175317948 0.32310308441434 no 1089 0.321842697754356 1516 2904180
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.461808775560678 0.323330501595318 no 1090 0.322109228600983 1618 688761
SGTC_2107 5363541 170.161 µM 0.461632501370946 0.323384436212049 no 1091 0.322172441550068 1529 244052
SGTC_2167 5876490 200 µM 0.46150398105759 0.323423761914056 no 1092 0.322218532924092 1714 686534
SGTC_2798 7813637 45.45 µM 0.460347433002892 0.323777740699824 no 1093 0.322633429884756 1597 956368
SGTC_681 1642-0006 26.6 µM 0.459466913915135 0.324047343641765 no 1094 0.322949453120981 1513 4446530
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.458953937228538 0.324204452675551 no 1095 0.323133622293225 1499 390807
SGTC_511 blebbistatin 171 µM 0.458114069593129 0.324461745967856 no 1096 0.323435245636109 1609 3476986 A myosin inhibitor.
SGTC_2634 4'-methoxyflavone 100 µM 0.456126124718534 0.325071086323748 no 1097 0.324149642473553 1540 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2034 5197015 53.07 µM 0.452487685478178 0.326187544193436 no 1098 0.325458845344589 1643 780676
SGTC_1960 st011366 51.8 µM 0.451932847412962 0.326357933968692 no 1099 0.325658680077767 1539 3972846
SGTC_282 k297-0036 65.7 µM 0.451053352094763 0.326628099654235 no 1100 0.325975548517933 1585 5061378
SGTC_1704 st028805 70.8 µM 0.449928566993659 0.326973746620085 no 1101 0.32638097422662 1536 2876101
SGTC_2910 7948405 25.97 µM 0.446966273681055 0.32788477059018 no 1102 0.327449705657411 1650 2971328
SGTC_3173 9105693 49.47 µM 0.446322025040597 0.328083038791932 no 1103 0.327682324371775 1615 17096658
SGTC_1701 st028638 40.4 µM 0.44522885730957 0.328419573151527 no 1104 0.328077187222255 1644 3490878
SGTC_2853 9015042 58.44 µM 0.44507512894166 0.328466909980331 no 1105 0.328132730834467 1470 6457456
SGTC_1755 st041960 45.185 µM 0.445040091877507 0.328477699158441 no 1106 0.32814539061151 1568 2257073
SGTC_466 geldanamycin 89.2 µM 0.443313418437508 0.329009581349536 no 1107 0.328769525705381 1595 5288382 HSP90 inhibitor.
SGTC_1278 0874-0585 172 µM 0.443171668081302 0.329053261340637 no 1108 0.32882078499926 1580 766306
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.442265117281553 0.32933266771073 no 1109 0.32914868501102 1523 6312947
SGTC_2252 omeprazole 400 µM 0.441843710512352 0.329462581190793 no 1110 0.329301152894428 1631 4594 A proton pump inhibitor.
SGTC_1490 4089-0339 670 nM 0.441655909966956 0.329520483956551 no 1111 0.329369109577536 1642 742542
SGTC_2921 7974240 10.71 µM 0.441303807680586 0.329629055339167 no 1112 0.329496534958946 1615 2979074 YDR527W RBA50
SGTC_2840 9008771 71.43 µM 0.439818009414093 0.33008736201033 no 1113 0.330034461438433 1712 2992978
SGTC_435 c-PAF 6.7 µM 0.437937728965394 0.330667715592004 no 1114 0.330715712344079 1565 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1933 st074711 15.9 µM 0.436284540675326 0.331178313158067 no 1115 0.331315148397349 1526 17250958
SGTC_400 oxethazaine 37.5 µM 0.436100069916247 0.331235307603066 no 1116 0.331382063223929 1552 4621 A local anesthetic.
SGTC_1116 jasmonic acid 1.58368 µM 0.435707661743874 0.331356559799094 no 1117 0.331524423062343 1623 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_496 calpeptin 138 µM 0.434149729080266 0.331838127668211 no 1118 0.332089857813019 1528 73364 A calpain inhibitor.
SGTC_214 4373-3496 70 µM 0.430761336127638 0.332886462504791 no 1119 0.333320957639542 1647 3779166
SGTC_797 k781-0471 270 µM 0.430535135714581 0.332956493297305 no 1120 0.33340320685929 1632 23738129
SGTC_571 k831-0106 44.2 µM 0.430366098017944 0.333008830533232 no 1121 0.333464676250445 1689 4783639
SGTC_1111 tnp00062 510.699 nM 0.429686410866438 0.333219307230448 no 1122 0.333711884916628 1698 676306
SGTC_502 l-744,832 89.3 µM 0.428993487274047 0.33343393689877 no 1123 0.333963982132746 1678 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_668 1682-0499 62.6 µM 0.427975688809826 0.33374929383646 no 1124 0.334334410140831 1578 682214
SGTC_2406 ethylparaben 405.7 µM 0.427745258517958 0.333820707187148 no 1125 0.334418297720721 1405 8434 A possible steroid mimic.
SGTC_995 3931-2021 34.6 µM 0.427285203909585 0.333963302110353 no 1126 0.334585804197762 1623 730143
SGTC_1108 betulinic acid 729.144 nM 0.426351681543748 0.334252723060034 no 1127 0.334925802072693 1572 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1614 st002383 48.6 µM 0.426149207551896 0.334315509304545 no 1128 0.334999562928934 1587 1947235
SGTC_1109 tnp00067 928.257 nM 0.425887797467287 0.334396578213454 no 1129 0.335094803494688 1570 676295
SGTC_1512 0259-0544 12.2 µM 0.425053560918488 0.33465534461043 no 1130 0.335398815073055 1650 18476
SGTC_515 4092-1064 102 µM 0.423476248263049 0.335144815526836 no 1131 0.335973912148899 1716 717353
SGTC_74 000s-0487 160.283 µM 0.423018393873 0.335286949169422 no 1132 0.336140920450295 1489 677548
SGTC_3237 9133362 49.47 µM 0.422715132060695 0.33538110497954 no 1133 0.336251556923824 1647 43845137
SGTC_2441 5730946 39.09 µM 0.419678644318995 0.33632443380078 no 1134 0.337360114002793 1689 1774275
SGTC_331 k048-0133 24.5 µM 0.419482090585661 0.336385531663969 no 1135 0.337431920392778 1575 6813582
SGTC_2914 7968218 45.32 µM 0.417672393941735 0.336948270759415 no 1136 0.338093329394494 1677 2977111
SGTC_1641 st009299 47.1 µM 0.416477608188879 0.337319998792477 no 1137 0.338530274600877 1629 4046054
SGTC_1505 k297-0037 20.6 µM 0.41626854698332 0.337385059355013 no 1138 0.338606752764258 1579 4089396
SGTC_3162 9099653 49.47 µM 0.414832274391473 0.337832163657643 no 1139 0.339132345624234 1628 25237511
SGTC_736 0958-0254 92.6 µM 0.410961961096869 0.339038110474771 no 1140 0.340550213705996 1659 6812352
SGTC_1039 k821-0043 94 µM 0.410311233545744 0.339241032464181 no 1141 0.340788826299943 1715 15992768
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.408930324263618 0.339671807754066 no 1142 0.341295397188055 1709 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_167 3672-0051 66.205 µM 0.408571484995599 0.339783782147076 no 1143 0.341427080169484 1553 3237971
SGTC_1444 4112-3581 28 µM 0.406450057018104 0.340446054067372 no 1144 0.342205973037483 1632 2877249
SGTC_117 lucigenin 22.078 µM 0.406030761419936 0.340577008998107 no 1145 0.342359999124104 1549 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_792 4534-1957 155 µM 0.40365512987393 0.341319331796905 no 1146 0.343233169728685 1651 1717904
SGTC_3313 9133968 57.047 µM 0.400358542378167 0.342350446722663 no 1147 0.344446227408559 1619 1494643
SGTC_1920 st075728 45.7 µM 0.399202167943213 0.34271241950101 no 1148 0.344872122970416 1762 3400306
SGTC_2225 6654152 15.4 µM 0.398889740392005 0.342810241577592 no 1149 0.344987224572279 1683 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1425 4048-4433 7.33 µM 0.397500419377726 0.343245370045868 no 1150 0.345499238673519 1687 23734946
SGTC_2027 5150920 200 µM 0.395213789015786 0.343961983826154 no 1151 0.34634255857123 1694 786715
SGTC_3206 9114350 49.47 µM 0.390408449533488 0.345469768501551 no 1152 0.348117270395484 1612 17087243
SGTC_2212 7123476 200 µM 0.389994472667941 0.345599778376909 no 1153 0.348270317073902 1703 1085715
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.389165472029458 0.345860181653695 no 1154 0.34857687173846 1614 16486 A toxic proline analog.
SGTC_1796 st049173 110.4 µM 0.38881457479755 0.345970426449422 no 1155 0.348706659204671 1701 94134
SGTC_1439 4092-1168 46 µM 0.3885957411126 0.346039186168063 no 1156 0.348787608876576 1663 2886240
SGTC_1511 0906-3109 28.5 µM 0.38855292967538 0.346052638540914 no 1157 0.348803446237296 1630 2882180
SGTC_1743 st037606 46.3785 µM 0.387846556686288 0.346274625789311 no 1158 0.34906479488738 1646 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2165 5727197 32.143 µM 0.387774526270115 0.346297265289138 no 1159 0.349091449212616 1701 1361712
SGTC_3014 9081533 49.47 µM 0.387330928919117 0.346436702133913 no 1160 0.349255615553151 1758 21367265
SGTC_1667 st014849 34.6 µM 0.385137354005178 0.347126518536824 no 1161 0.350067827043966 1658 5348460
SGTC_36 0335-0881 14.2 µM 0.384870849403048 0.347210361165495 no 1162 0.350166552112103 1661 23828853
SGTC_1919 st067113 52.3 µM 0.383820169031956 0.347540979143023 no 1163 0.350555869102899 1620 1268243
SGTC_1713 st033146 12.748 µM 0.383307720579946 0.347702273589429 no 1164 0.350745807716205 1762 674619
SGTC_5 0352-0601 109.883 µM 0.382064186450091 0.348093793682368 no 1165 0.351206877705359 1675 762456
SGTC_1618 st003135 44.5 µM 0.381910808795281 0.348142095048815 no 1166 0.351263761326936 1702 1270615
SGTC_326 k292-0812 17.5 µM 0.379185998565935 0.349000596509122 no 1167 0.35227487406327 1768 3579357
SGTC_479 n-linoleoylglycine 10 µM 0.377340523786787 0.349582486841193 no 1168 0.352960280262478 1656 6433346 An anti-infammatory.
SGTC_926 2268-1401 59.4 µM 0.377175809780829 0.349634439458408 no 1169 0.353021478003437 1635 2931578
SGTC_230 MPP+ 141.667 µM 0.371938770891734 0.351287722956745 no 1170 0.3549692188166 1610 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1044 1222-0021 1.78 µM 0.371712243718885 0.351359299240698 no 1171 0.355053554010947 1711 4306703
SGTC_1402 3909-7673 35.9 µM 0.369924526506454 0.351924352925538 no 1172 0.3557193631152 1637 5328014
SGTC_864 0469-0573 172 µM 0.369242464446157 0.352140022356439 no 1173 0.355973503324846 1648 689425
SGTC_2863 9028737 58.44 µM 0.368634370848938 0.352332342918106 no 1174 0.356200136442544 1786 6460917
SGTC_2941 9056145 11.23 µM 0.368160323128803 0.352482295252969 no 1175 0.356376846650579 1681 2119517
SGTC_372 0155-0182 15.9 µM 0.366828089992941 0.352903834326099 no 1176 0.356873626649313 1738 771486
SGTC_1455 4262-0120 131 µM 0.36681608190609 0.352907634691754 no 1177 0.356878105482541 1756 1529587
SGTC_2723 salbutamol 83.58 µM 0.365064185390099 0.35346223873206 no 1178 0.357531747265468 1753 9884233 β2-adrenoceptor agonist
SGTC_1144 3486-0183 12.5 µM 0.364936336082992 0.353502724637375 no 1179 0.357579464906056 1694 6744069
SGTC_130 0136-0219 337.655 µM 0.364893684510365 0.353516231434646 no 1180 0.357595384395829 1796 234244
SGTC_2816 7982706 58.44 µM 0.363216066543725 0.3540476416051 no 1181 0.358221743326292 1665 2981853
SGTC_1447 4239-0816 81.9 µM 0.36308741726275 0.354088404911497 no 1182 0.358269791869758 1619 1341554
SGTC_2954 9074818 52.69 µM 0.36196657926217 0.354443619946801 no 1183 0.358688502645304 1738 16648742
SGTC_2411 st077133 39.94 µM 0.358522414095469 0.355535933207153 no 1184 0.359976198588943 1832 1403142 YNL221C POP1
SGTC_2953 9074162 66.49 µM 0.357943390037397 0.35571968691267 no 1185 0.360192839257629 1849 16451992
SGTC_2641 levomentholum 100 µM 0.357899639522664 0.355733572533363 no 1186 0.36020921024883 1728 16666
SGTC_632 0781-2353 4.65 µM 0.357679125805766 0.355803562505386 no 1187 0.360291728108022 1732 6811515 YHR007C ERG11
SGTC_3336 9143619 71.43 µM 0.357639392082928 0.355816174311013 no 1188 0.360306597452305 1761 45595730
SGTC_1575 cyproterone acetate 48 µM 0.355431583462185 0.356517198302638 no 1189 0.361133145658069 1623 9880 An androgen receptor antagonist and liver toxin.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.354264506714765 0.356887964950857 no 1190 0.361570332318501 1595 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_305 1682-2595 20.8 µM 0.351537454431179 0.357754844226894 no 1191 0.362592589311182 1734 226033
SGTC_1606 st000094 49.2 µM 0.349884790770272 0.3582805529199 no 1192 0.363212580847238 1859 1242210
SGTC_152 4469-0003 551.229 µM 0.345978870272967 0.359524084336739 no 1193 0.364679297168343 1797 697280
SGTC_1087 pterostilbene 9.05 µM 0.345677857172492 0.35961998011354 no 1194 0.364792413482922 1822 5281727 Similar to reservatol, lowers cholesterol.
SGTC_900 1112-0045 141 µM 0.343094394441376 0.36044337423427 no 1195 0.365763724032599 1698 56211 YIL048W NEO1
SGTC_3214 9129694 49.47 µM 0.342267095619486 0.360707185714457 no 1196 0.366074947860529 1824 17158655
SGTC_2496 diffractaic acid 79.83 µM 0.341880786903356 0.36083039568931 no 1197 0.366220304601463 1844 94870 An apoptosis inducer which activates caspases.
SGTC_452 diindolylmethane 8 µM 0.340690405582915 0.361210148768117 no 1198 0.366668331135155 1757 3071 Inhibits expression of several cancer promoting factors.
SGTC_371 0195-0006 7.36 µM 0.339943826068382 0.361448390915145 no 1199 0.366949415738731 1623 3928593
SGTC_798 1287-0182 476 µM 0.335440839990787 0.362886482240009 no 1200 0.36864628240327 1852 1649755
SGTC_1052 3253-3998 198 µM 0.33542325256742 0.362892102836755 no 1201 0.368652914945692 1693 5450317
SGTC_194 1486-1323 56.904 µM 0.334759286082317 0.36310431514323 no 1202 0.368903337584336 1694 5178754
SGTC_300 r073-0011 5.04 µM 0.331888325640902 0.364022394454941 no 1203 0.369986793012353 1773 2735780
SGTC_2746 daunorubicin 9.88 µM 0.331755655707255 0.364064838731039 no 1204 0.370036885592245 1840 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2717 st081029 62.2815 µM 0.328232865058796 0.365192472004547 no 1205 0.371367800190082 1856 5292846
SGTC_71 0417-1750 47.813 µM 0.32681169094316 0.365647715801402 no 1206 0.37190515823429 1889 6811472
SGTC_818 4072-2707 53.5 µM 0.326498083165641 0.365748199097374 no 1207 0.372023769662885 1660 882871
SGTC_222 nsc-310342 10.666 µM 0.326285985086152 0.365816162819471 no 1208 0.372103995401355 1855 432556
SGTC_273 hydroxyurea 18.1 mM 0.325895525215129 0.365941290976407 no 1209 0.372251700701254 1774 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1076 itraconazole 331 nM 0.324530932071153 0.366378705274229 no 1210 0.372768053977722 1750 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2654 protoveratrine a 100 µM 0.323947799517794 0.366565678827971 no 1211 0.372988777391361 1783 5702278 A heart drug and vasodilator.
SGTC_1654 st012436 41.8 µM 0.321952781766932 0.367205593528478 no 1212 0.373744233058704 1835 4323132
SGTC_1286 0929-0070 131 µM 0.320433088164354 0.367693292705826 no 1213 0.374320023021359 1810 1420408
SGTC_487 nimodipine 119 µM 0.320007295891809 0.367829976020607 no 1214 0.374481399914197 1850 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1070 indatraline 8.81 µM 0.319764199232814 0.367908019836769 no 1215 0.374573544336767 1716 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2014 4013930 200 µM 0.319761235680116 0.367908971290169 no 1216 0.374574667698968 1857 64556
SGTC_2879 9041815 71.43 µM 0.319377811917588 0.368032076944444 no 1217 0.37472001701599 1776 4942971
SGTC_2033 5192550 145 µM 0.318826664072266 0.368209057419076 no 1218 0.374928978809955 1719 182073
SGTC_157 1348-1695 65.819 µM 0.318130921695514 0.368432508946728 no 1219 0.375192814499523 1732 5380510
SGTC_991 3996-0057 64.7 µM 0.31588771965339 0.36915326069775 no 1220 0.376043866669236 1755 715343
SGTC_485 niflumic acid 177 µM 0.315070486377087 0.369415956252582 no 1221 0.376354068294933 1809 4488 A COX2 inhibitor.
SGTC_592 k241-0073 46.5 µM 0.314985263822288 0.369443354130328 no 1222 0.376386421280686 1847 4230158
SGTC_613 3914-0030 117 µM 0.314932228880267 0.36946040446853 no 1223 0.376406555341333 1777 1145395
SGTC_2808 7946468 45.46 µM 0.314645118652777 0.36955271272106 no 1224 0.376515559029611 1790 2970879
SGTC_1074 carmofur 3.8 µM 0.314003507013264 0.369759023205777 no 1225 0.376759187587649 1771 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2381 9035592 200 µM 0.312817884244405 0.370140359315796 no 1226 0.377209513576772 1693 4749657
SGTC_961 1252-1571 372 µM 0.312514980934708 0.370237803688114 no 1227 0.377324589827561 1876 6813498
SGTC_1221 2958-7315 257 µM 0.312070580764547 0.370380782848836 no 1228 0.37749344198256 1785 4562705
SGTC_1315 1237-0019 3.69 µM 0.311256922595216 0.370642611692447 no 1229 0.377802656303962 1844 825140
SGTC_1737 st035557 69.7 µM 0.310012702515557 0.371043107837965 no 1230 0.378275648356304 1701 5716916
SGTC_353 1988-1175 58.3 µM 0.309943387368014 0.371065423477121 no 1231 0.378302003981549 1706 2788357
SGTC_3272 9137413 49.47 µM 0.309713820113362 0.371139334516277 no 1232 0.378389296138458 1669 17614870
SGTC_2768 sulfasalazine 50.2 µM 0.309633019386424 0.371165350096586 no 1233 0.378420021813183 1891 5384001 An antioxidant and salicylic acid derivative.
SGTC_1806 st050005 60.3 µM 0.305961040754439 0.372348244401479 no 1234 0.379817154570312 1724 5194765
SGTC_2333 9017922 200 µM 0.303633485419475 0.373098669978021 no 1235 0.380703568791419 1887 3163164
SGTC_193 1273-0060 1.558 µM 0.303536171424844 0.373130055428874 no 1236 0.38074064303187 1867 2847393 YHR072W ERG7
SGTC_3219 9131112 49.47 µM 0.3021727437583 0.373569872937866 no 1237 0.381260190477739 1807 17612988 YMR079W SEC14
SGTC_1705 st027868 56.3335 µM 0.300533569985246 0.37409885926539 no 1238 0.381885097015756 1869 292948
SGTC_719 2810-4230 27.3 µM 0.299856951923266 0.374317283423963 no 1239 0.382143135775006 1801 721079
SGTC_3087 9117406 49.47 µM 0.299320901582811 0.374490358508598 no 1240 0.382347604037703 1779 42546093
SGTC_1770 st043884 66.3 µM 0.296871505873938 0.375281518564727 no 1241 0.383282305502544 1772 670149
SGTC_910 3454-3003 490 µM 0.292630367665795 0.376652654956457 no 1242 0.384902349655221 1902 820824
SGTC_943 3253-1379 105 µM 0.292555404948222 0.376676904044242 no 1243 0.384931002337438 1865 668464
SGTC_713 1488-1073 324 µM 0.292357340635588 0.376740976619936 no 1244 0.385006710644387 1914 3312542
SGTC_2673 kobusone 100 µM 0.28851250404752 0.377985428061468 no 1245 0.386477230207955 1842 6710676 An epoxy ketone and protein crosslinker.
SGTC_2091 4-phenylthiadiazole 200 µM 0.285444961312303 0.378979203715017 no 1246 0.387651632745534 1789 270010
SGTC_1217 1183-1422 255 µM 0.284145508487182 0.379400422361722 no 1247 0.388149436429463 1882 2849664
SGTC_2655 perillic acid 100 µM 0.284029598257961 0.379438001716181 no 1248 0.388193849091188 1784 5702197 An apoptosis inducer.
SGTC_2145 5634607 200 µM 0.283520906996248 0.379602938409 no 1249 0.388388778704081 1740 308662
SGTC_34 0469-0683 81.75 µM 0.283300793312362 0.379674314273761 no 1250 0.38847313460531 1874 3690923
SGTC_3073 9114972 49.47 µM 0.283182020315681 0.37971283028107 no 1251 0.388518655101918 1939 41905075
SGTC_2859 9028643 45.46 µM 0.278907380941995 0.381099812758583 no 1252 0.390157952026672 1903 17151580
SGTC_2515 chrysin 20.77 µM 0.277140262053483 0.381673633483383 no 1253 0.39083620373945 1900 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_554 4483-2211 187 µM 0.277086228973181 0.381691183267561 no 1254 0.390856947843175 1824 747107
SGTC_3104 9120930 49.47 µM 0.273495920729179 0.382857848017715 no 1255 0.392236013822041 1833 17014836
SGTC_1415 3966-0071 78.1 µM 0.270709047456293 0.38376417174784 no 1256 0.393307408849067 1861 2893185
SGTC_3283 9109332 35.8195 µM 0.270136363763409 0.383950494136049 no 1257 0.393527673719606 1809 17027281
SGTC_2832 7992762 51.95 µM 0.26820310624336 0.38457967653654 no 1258 0.394271492062734 1635 2985177
SGTC_1907 st060210 83.7 µM 0.268165821632516 0.384591813880022 no 1259 0.394285841068813 1924 688793
SGTC_2434 5670830 169.91 µM 0.267466331488889 0.384819541441852 no 1260 0.394555066866967 1825 1549830
SGTC_577 r071-0003 38.6 µM 0.266759002232728 0.385049861535798 no 1261 0.394827361074037 1805 4568517 YMR134W ERG29
SGTC_557 1315-0110 16.2 µM 0.266442640687963 0.385152888109609 no 1262 0.394949164581589 1790 6833801
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.265905427890243 0.385327855861982 no 1263 0.395156022347261 1910 688751
SGTC_368 fentichlor 4.58 µM 0.26474730221342 0.38570513146594 no 1264 0.395602067665072 1794 7329 A pesticide.
SGTC_1779 st039427 55 µM 0.258696195351849 0.387678115151397 no 1265 0.397934827666174 2023 1124498
SGTC_3128 9127691 49.47 µM 0.257215471756098 0.388161354230851 no 1266 0.398506220494586 1858 41316314
SGTC_2898 9056270 58.44 µM 0.256885665674278 0.388269011156825 no 1267 0.398633518242726 1875 19154699
SGTC_859 0439-0102 54.6 µM 0.256518268243601 0.388388948944872 no 1268 0.398775338107039 1985 610143
SGTC_1297 1068-0111 14.1 µM 0.255189559774925 0.388822797839737 no 1269 0.399288347142821 1792 767057
SGTC_3018 9082602 49.47 µM 0.255170817594616 0.38882891851563 no 1270 0.39929558467014 1870 17332089
SGTC_2864 9034755 47.6 µM 0.255166047355057 0.388830476347876 no 1271 0.39929742676333 2016 4930451
SGTC_1258 0671-0043 57.1 µM 0.254018493170627 0.389205288638312 no 1272 0.399740635551354 1801 4298767
SGTC_349 k015-0014 24 µM 0.253551634968964 0.389357802636867 no 1273 0.399920982701205 1800 2196908
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.253542054674399 0.389360932521671 no 1274 0.39992468378911 1949 16725076
SGTC_469 w7 172 µM 0.252350547748655 0.389750254049812 no 1275 0.400385060276198 1904 45115570 A P450 inhibitor.
SGTC_566 0958-0068 16.5 µM 0.250425678088119 0.390379433394243 no 1276 0.40112908693516 1910 6815365
SGTC_2295 7971645 200 µM 0.249921549839634 0.390544264587554 no 1277 0.401324008790284 1905 2978226 YKL099C UTP11
SGTC_3261 9137475 49.47 µM 0.249302511779631 0.390746693924858 no 1278 0.401563394266998 1917 17027690
SGTC_3331 9141060 1.957 µM 0.249119900760535 0.390806414534564 no 1279 0.401634018029323 1811 4906567 YPR165W RHO1
SGTC_2584 androsterone 48.74 µM 0.245982148995325 0.391832977523786 no 1280 0.402848025530943 1925 2754130 A steroid.
SGTC_927 2425-1185 123 µM 0.24509055765959 0.392124812918743 no 1281 0.403193156949921 1815 730375
SGTC_546 peri-Naphthalide 147 µM 0.242371302742483 0.393015252758781 no 1282 0.404246234322916 1940 223824 A penicillin ester.
SGTC_581 0958-0271 211 µM 0.24235143451027 0.393021760822882 no 1283 0.404253931195091 1836 4591145
SGTC_2507 purpurin 79.67 µM 0.242331274065608 0.393028364635039 no 1284 0.40426174130706 1776 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_455 paf C-16 10 µM 0.241723255842796 0.393227543256882 no 1285 0.404497304145334 1872 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2625 euphol 100 µM 0.241457154821839 0.393314723181835 no 1286 0.404600409833936 2004 6708538 A triterpene alcohol.
SGTC_370 0180-0345 38.7 µM 0.241208030478373 0.393396346062305 no 1287 0.404696943604137 1846 3989527
SGTC_1675 st018485 24.5 µM 0.239352815746875 0.394004334120793 no 1288 0.405416007137525 1873 3323024
SGTC_1527 coumarin 137 µM 0.238849479018246 0.394169331471631 no 1289 0.405611150828548 1948 323 A hepatotoxic, DNA x-linker.
SGTC_482 fipronil 114 µM 0.238820858801948 0.394178713952604 no 1290 0.405622247594159 1925 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1792 st045773 43.6 µM 0.237008993687863 0.394772817123105 no 1291 0.406324906534469 1859 2919270
SGTC_2772 vinpocetine 57.06 µM 0.236292815555013 0.39500771658563 no 1292 0.406602730736316 1953 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2377 9073351 62.6 µM 0.23600855502772 0.395100961859264 no 1293 0.40671301586133 1825 7337946 YHR072W ERG7
SGTC_2063 5246145 200 µM 0.235120522432814 0.395392299658508 no 1294 0.407057595266584 1938 711240
SGTC_1192 1488-0095 21.4 µM 0.23202857287041 0.396407134093958 no 1295 0.408257910688482 1909 915875
SGTC_2529 gangaleoidin 93.61 µM 0.231404670975241 0.396611995485537 no 1296 0.40850021836077 1908 4565183
SGTC_1181 1222-0449 220 µM 0.231145890033411 0.396696975914777 no 1297 0.408600732585376 1964 658318
SGTC_2730 imipramine 71.33 µM 0.229869496019306 0.397116199479918 no 1298 0.409096590145826 2011 3696 A tricyclic antidepressant.
SGTC_447 ml7 120 µM 0.227390917099267 0.397930612326802 no 1299 0.410059891212752 2022 4216 Selective myosin light chain kinase inhibitor.
SGTC_380 3970-0968 6 µM 0.225049811575916 0.398700262806138 no 1300 0.410970261991916 1884 2891601
SGTC_1954 st077032 68.9 µM 0.222357076720478 0.399586000451329 no 1301 0.412017961605306 1809 698907
SGTC_3307 9126885 69.2785 µM 0.222101406109814 0.399670126686688 no 1302 0.412117471639499 1850 24824909
SGTC_1267 0828-0272 9.49 µM 0.220658836127763 0.400144879219123 no 1303 0.41267904269776 2017 745334
SGTC_2756 carbadox 75.1 µM 0.220216226249202 0.400290572599078 no 1304 0.412851380040883 1898 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2889 9059656 51.95 µM 0.21783588426782 0.401074344511947 no 1305 0.413778492136819 1965 3949838
SGTC_2309 7664088 163.95 µM 0.216751938120813 0.401431386138787 no 1306 0.414200834638036 2072 704922
SGTC_3225 9130819 49.47 µM 0.216305292246973 0.401578531036382 no 1307 0.414374892048565 1997 4547121
SGTC_3302 9125395 16.351 µM 0.213265819160218 0.402580237465551 no 1308 0.415559816307247 1928 17599668
SGTC_1969 st069479 40.1 µM 0.209682084162196 0.403762135703746 no 1309 0.416957904730417 2023 3895485
SGTC_2908 7930301 100 µM 0.209288168041609 0.403892101139329 no 1310 0.417111643897515 1960 2223178
SGTC_3274 9138298 49.47 µM 0.207693262498324 0.404418419428935 no 1311 0.417734239359515 2055 17015756
SGTC_3118 9124250 49.47 µM 0.203048865063718 0.405952051259644 no 1312 0.419548419421975 1929 1504786
SGTC_708 3448-5400 146 µM 0.202055984007893 0.406280099858331 no 1313 0.419936478875756 2058 3462195
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.199720750805532 0.40705192154034 no 1314 0.420849491966185 2059 688662
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.199647749128575 0.40707605527796 no 1315 0.420878040539964 2064 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_16 erodoxin 22.806 µM 0.199331848793986 0.407180493325147 no 1316 0.421001583646979 2009 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2060 5238662 140 µM 0.199169833805166 0.407234058757441 no 1317 0.421064947900092 1931 790130
SGTC_308 4092-1169 104 µM 0.199051829465736 0.407273074470932 no 1318 0.42111110082343 1980 2268590 YDL196W YDL196W
SGTC_2774 tamoxifen 10.92 µM 0.198551978885126 0.407438350006616 no 1319 0.421306610441055 2021 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3078 9116413 49.47 µM 0.198057014279752 0.407602026233365 no 1320 0.421500228098409 2020 17177322
SGTC_2670 beta-carotene 100 µM 0.196745809545838 0.408035696834192 no 1321 0.422013229910255 2037 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_523 1934-0222 13.7 µM 0.196436144948614 0.40813813242032 no 1322 0.422134403873289 1884 1361595
SGTC_541 4513-1321 94 µM 0.196331608296868 0.408172714068805 no 1323 0.422175311474611 1893 747515
SGTC_223 busulfan 5 mM 0.195928299583827 0.408306138856756 no 1324 0.422333143334248 2030 2478 A DNA alkylator.
SGTC_1369 1866-0067 208 µM 0.195449360790497 0.408464597807726 no 1325 0.422520588660135 2061 3531355
SGTC_1194 1488-0194 225 µM 0.195224354996005 0.4085390471076 no 1326 0.422608656671809 1962 1391452
SGTC_3294 9122953 26.2835 µM 0.194924211857985 0.408638362783456 no 1327 0.422726139709462 1996 16459826
SGTC_1419 3993-2473 62.6 µM 0.194687818873933 0.408716588022729 no 1328 0.422818674286412 1983 704026
SGTC_1462 k081-0014 26.5 µM 0.193567660871393 0.409087310971264 no 1329 0.423257211053115 2016 3270634
SGTC_1401 3807-4679 7.6 µM 0.19297918919813 0.409282101778426 no 1330 0.423487633174287 1973 3291456
SGTC_1416 3966-0321 25.3 µM 0.192881000733841 0.409314605457227 no 1331 0.423526082424386 1978 582530 YLR208W SEC13
SGTC_2607 solasodine 47.35 µM 0.189201936910306 0.41053294656356 no 1332 0.42496727482372 1933 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_422 cantharidin 155 µM 0.189026277855135 0.4105911386724 no 1333 0.42503611064878 1870 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_395 anisomycin 6.25 µM 0.188644151100896 0.410717735934928 no 1334 0.42518586322836 1956 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3179 9107801 49.47 µM 0.181500929142826 0.413085958782571 no 1335 0.427987201956735 1990 4818259
SGTC_1398 3558-0053 112 µM 0.180257960068514 0.413498371458046 no 1336 0.42847502900274 1974 4532369
SGTC_474 dl-dihydrosphingosine 5 µM 0.180237772206258 0.413505070507185 no 1337 0.428482953020464 2071 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1885 st057546 99.9 µM 0.179412170892109 0.41377905587062 no 1338 0.42880703772507 2066 702008
SGTC_1008 4106-0037 6 µM 0.179230699884273 0.41383928475982 no 1339 0.428878279493479 1989 2905394
SGTC_91 0417-1751 58.384 µM 0.178801038737108 0.413981894203942 no 1340 0.429046964816753 2111 6795624
SGTC_1819 st053448 58.6 µM 0.17862884695778 0.414039049808092 no 1341 0.429114571091603 1997 2857616
SGTC_882 0843-0131 351 µM 0.177926213468376 0.41427229374952 no 1342 0.429390461967858 2111 5425421
SGTC_289 k017-0060 526 µM 0.17776633515873 0.414325370662076 no 1343 0.429453243426057 2016 5512909
SGTC_1789 tunicamycin 25 nM 0.176905999677935 0.414611014426178 no 1344 0.429791112946214 2105 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1350 1495-0454 146 µM 0.176425549194653 0.414770550563868 no 1345 0.429979817055728 2070 1069057
SGTC_138 0850-0259 40.9225 µM 0.176048896768516 0.414895629836677 no 1346 0.430127764114282 2097 6813004
SGTC_2661 dactinomycin 12.96 µM 0.175900940911317 0.414944765588874 no 1347 0.430185883068612 2065 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_973 1325-0077 65.9 µM 0.17586552636853 0.414956526863056 no 1348 0.430199794578679 2060 2835149
SGTC_1107 amlodipine 47 µM 0.175648629533923 0.415028560604542 no 1349 0.430284997695332 2035 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3224 9130643 49.47 µM 0.175344196983383 0.415129670704859 no 1350 0.430404592753528 2030 17644395
SGTC_1222 0366-0074 1.18 µM 0.175147213138137 0.415195097244668 no 1351 0.430481980438435 2101 286520
SGTC_2643 anethole 100 µM 0.173600962149585 0.41570875314838 no 1352 0.431089537908707 2011 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3042 9091578 49.47 µM 0.171989610275199 0.416244188472894 no 1353 0.43172284854319 2099 25236497
SGTC_2442 5158906 48.48 µM 0.171279116090013 0.416480327687029 no 1354 0.432002150375266 2079 1893835
SGTC_803 4488-1585 147 µM 0.171049062985117 0.416556794396735 no 1355 0.432092593668933 2085 747204
SGTC_2504 purpurogallin 52.29 µM 0.170669672183763 0.416682905943241 no 1356 0.432241755497031 1949 5281571 An antioxidant.
SGTC_3094 9117742 49.47 µM 0.170495545456308 0.416740789477518 no 1357 0.432310218644352 2111 17149698
SGTC_1791 st048313 56.1 µM 0.16907248054458 0.41721391494513 no 1358 0.432869815314564 2119 1204976
SGTC_2281 7943571 200 µM 0.168891743946172 0.417274012919953 no 1359 0.432940896643702 2158 1244024
SGTC_2369 9071472 200 µM 0.168763587772524 0.41731662818573 no 1360 0.432991300097605 2018 17296037
SGTC_2056 5235370 200 µM 0.167125939475958 0.417861274238635 no 1361 0.433635478147307 1983 5511916
SGTC_1759 st043059 70 µM 0.166982675900307 0.41790892808534 no 1362 0.433691840082074 1959 669426
SGTC_3262 9137218 49.47 µM 0.166104767628568 0.418200973524547 no 1363 0.434037251127557 2106 17650664
SGTC_2700 st077718 96.8 µM 0.165901051409115 0.418268748325447 no 1364 0.434117410028497 1970 904970
SGTC_23 0213-0011 39.996 µM 0.165687665157284 0.418339742873177 no 1365 0.434201376829344 2121 627608
SGTC_2102 5377816 72.7585 µM 0.165064982447599 0.418546927359485 no 1366 0.434446417422128 2120 1379702
SGTC_174 3553-0389 74.3 µM 0.16500385295374 0.418567268123212 no 1367 0.434470474704484 2053 738071
SGTC_3089 9117425 49.47 µM 0.164628036675926 0.418692325308659 no 1368 0.434618381115298 1947 9401657
SGTC_2279 7948423 32.93 µM 0.163913297634325 0.418930185604178 no 1369 0.434899699345208 2133 1247112
SGTC_2469 5655019 90.81 µM 0.163348795374124 0.419118069072216 no 1370 0.43512190832326 2099 2788239
SGTC_1661 st013063 9.66 µM 0.162970143338631 0.419244106289456 no 1371 0.435270971262232 2035 721395
SGTC_2463 5473429 200 µM 0.161310414200197 0.419796657392946 no 1372 0.435924460666069 2012 5399405
SGTC_594 1487-1584 10.8 µM 0.160999822911215 0.419900075936502 no 1373 0.436046770058901 1966 5013332
SGTC_2473 5854593 8.94 µM 0.157134927840211 0.421187442494667 no 1374 0.437569255530901 1986 2872951
SGTC_405 ebelactone b 50 µM 0.155897970683211 0.42159964207535 no 1375 0.438056722456081 1999 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3339 9145883 14.936 µM 0.155613479733557 0.421694457084037 no 1376 0.438168849548556 2118 2030670
SGTC_2171 5739187 198.077 µM 0.155050996313823 0.42188193464754 no 1377 0.438390557073812 2034 2262761
SGTC_1833 st055984 71 µM 0.154858827452699 0.421945989217349 no 1378 0.438466306466229 1998 676288
SGTC_1474 0330-0125 5.35 µM 0.153699787525013 0.422332369229832 no 1379 0.438923226160912 2119 X1474
SGTC_3347 9188721 44.724 µM 0.153518744399477 0.422392728910331 no 1380 0.438994604812529 2054 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_695 3505-6186 243 µM 0.151134626266691 0.423187762119318 no 1381 0.439934759201369 2079 1819379
SGTC_1378 2093-0007 380 nM 0.150845831920844 0.423284087841542 no 1382 0.440048665625173 2032 3618014
SGTC_2203 7227154 166.4 µM 0.150337896511629 0.423453517949174 no 1383 0.440249017820361 2141 896304
SGTC_2297 7971671 152.32 µM 0.149362581213155 0.423778889870098 no 1384 0.440633768170506 2112 909016
SGTC_2810 7959871 45.46 µM 0.149275488178142 0.42380794723914 no 1385 0.440668128074215 2090 2974535
SGTC_1340 1486-1359 257 µM 0.149030533364392 0.423889675196214 no 1386 0.44076476992776 2038 4309068
SGTC_2404 5161160 200 µM 0.148989236935957 0.423903453867041 no 1387 0.440781062926843 2037 2831543
SGTC_3115 9123671 49.47 µM 0.145875917241188 0.424942488543552 no 1388 0.442009671726643 2175 3286988
SGTC_3108 9121785 49.47 µM 0.145488728570718 0.425071744932305 no 1389 0.442162507181757 2161 17140271
SGTC_620 0109-0052 432 µM 0.144970437069995 0.425244780389577 no 1390 0.442367106488808 2159 493037
SGTC_1093 fluphenazine 7.97 µM 0.144323025169647 0.42546094387521 no 1391 0.442622698593921 2055 6602611 An atypical antipsychotic.
SGTC_2026 5148700 152 µM 0.143230875088732 0.425825651142589 no 1392 0.443053923205981 2058 79838
SGTC_2595 hexamethylquercetagetin 100 µM 0.14318661740505 0.425840431677486 no 1393 0.443071399338484 2050 386331
SGTC_3099 9120367 49.47 µM 0.143169733879432 0.425846070218277 no 1394 0.44307806620394 2133 24824940
SGTC_789 1309-1135 70.6 µM 0.142505446943299 0.42606793217167 no 1395 0.443340388621622 2159 3092424
SGTC_902 1120-0002 2.07 µM 0.141252946003305 0.426486312458967 no 1396 0.443835060233963 2144 3280475
SGTC_2638 epoxomicin 18 µM 0.139952985862805 0.426920633319199 no 1397 0.444348568271953 2158 9915668 A protesome inhibitor.
SGTC_2298 7976326 193.81 µM 0.139760025160404 0.426985109675398 no 1398 0.444424799263855 2103 2235818
SGTC_3182 9108849 49.47 µM 0.137294930207301 0.427808973536502 no 1399 0.445398838799359 2079 17133045
SGTC_1822 st052468 42 µM 0.135047045493751 0.428560517727617 no 1400 0.446287339038622 2103 2873678
SGTC_754 3474-0146 171 µM 0.132515506624324 0.429407207270179 no 1401 0.447288279336675 1960 24762078
SGTC_1925 st057770 10.1 µM 0.131455214935485 0.429761925428557 no 1402 0.447707606183747 1928 5989122
SGTC_1216 1165-0504 9.65 µM 0.130892137371275 0.429950324811663 no 1403 0.44793031731925 2184 6304004
SGTC_667 1498-1044 59 µM 0.128885646732122 0.43062180328526 no 1404 0.448724067092209 2094 6739982
SGTC_1761 st044296 37 µM 0.12775803400925 0.430999250656783 no 1405 0.449170230919193 2136 1826700
SGTC_2512 diallyl trisulfide 49.23 µM 0.127420791261173 0.43111214864995 no 1406 0.449303680658822 2187 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3297 9117502 71.43 µM 0.125886765272053 0.431625761968224 no 1407 0.449910779555267 2222 7453720
SGTC_2111 5486399 200 µM 0.12582965244176 0.431644886378864 no 1408 0.449933384532472 2148 689674
SGTC_2918 7977171 22.06 µM 0.125407320941041 0.431786310378545 no 1409 0.450100546299728 2152 2236483
SGTC_2311 7694451 200 µM 0.125252047689119 0.431838308141066 no 1410 0.450162006768341 2122 2163142
SGTC_3348 9149464 3.537 µM 0.122822779560666 0.432651972404358 no 1411 0.45112371767624 2214 1951442
SGTC_189 3970-0742 2.116 µM 0.121814715500735 0.432989699600066 no 1412 0.451522879730403 2206 2891807
SGTC_3255 9139072 49.47 µM 0.121453641953438 0.433110680375939 no 1413 0.45166586558328 2095 17646060
SGTC_272 doxorubicin 8.13 µM 0.120791912598715 0.433332414712459 no 1414 0.451927928005426 2178 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2592 piperlongumine 83.33 µM 0.118971629928529 0.433942468772737 no 1415 0.45264891607672 2067 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_975 1335-0046 28.5 µM 0.1177958951863 0.434336591184753 no 1416 0.453114691035344 2059 16486740
SGTC_449 xestospongin c 11.1929 µM 0.11712936189408 0.434560051302966 no 1417 0.453378771224328 2137 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_765 1319-0117 244 µM 0.116985167889074 0.434608396141745 no 1418 0.453435903540505 2219 3487746 YGL099W LSG1
SGTC_1843 st055809 45.5 µM 0.11465695219834 0.435389126645214 no 1419 0.454358517996918 2101 16413835
SGTC_2172 5754775 163.918 µM 0.114147572330091 0.435559972863469 no 1420 0.454560405688106 2096 2263357
SGTC_347 4534-1311 26.2 µM 0.113401864607763 0.435810105226064 no 1421 0.454855980752897 2183 2862016
SGTC_506 n9-isopropylolomoucine 153 µM 0.112198127782934 0.436213928198517 no 1422 0.455333156805378 2227 6610355
SGTC_1634 st006576 41 µM 0.11196494962368 0.436292161219196 no 1423 0.455425598962664 2203 3915356
SGTC_2194 5927483 104.545 µM 0.111727764326489 0.436371741221652 no 1424 0.455519632203064 2203 760979
SGTC_492 tmb-8 126 µM 0.110978821642878 0.436623042072632 no 1425 0.455816570428644 2207 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3289 9119912 71.43 µM 0.109956534869905 0.436966102295692 no 1426 0.456221922986232 2162 17014829
SGTC_415 dibenzyl ketone 100 µM 0.109277960321489 0.437193845351034 no 1427 0.456491013504728 2182 7593
SGTC_1864 st057645 30.4 µM 0.10915580944825 0.437234843815584 no 1428 0.456539454877058 2232 688666
SGTC_3036 9090181 49.47 µM 0.108540903162236 0.437441239907699 no 1429 0.456783318060547 2190 25236586
SGTC_1317 1273-0028 910 nM 0.107256097955936 0.437872545503984 no 1430 0.457292906159873 2132 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_884 0851-0618 334 µM 0.106167785034476 0.438237946947478 no 1431 0.4577246151367 2212 9642473
SGTC_1001 4048-4355 44.4 µM 0.106139376628001 0.43824748578647 no 1432 0.457735884775518 2181 21824233
SGTC_607 4491-0986 66.8 µM 0.105994013366829 0.438296295729122 no 1433 0.457793551035473 2201 698981 YDR232W HEM1
SGTC_1253 0550-0034 176 µM 0.10303897981178 0.439288736654741 no 1434 0.458966017083529 2132 5969915
SGTC_2818 7996756 12.99 µM 0.102970721424857 0.439311665604654 no 1435 0.458993104161291 2182 2241621
SGTC_2694 st077685 81.9 µM 0.101956166262375 0.439652492882466 no 1436 0.459395733980697 2161 2838096
SGTC_2396 5342950 42.78 µM 0.101742538957161 0.43972426404719 no 1437 0.459480518057525 2115 1886677
SGTC_2216 7189485 200 µM 0.101636677161582 0.439759830573724 no 1438 0.45952253300748 2214 731273
SGTC_2961 9083290 32.55 µM 0.100216100594187 0.440237150473142 no 1439 0.460086381969132 2238 17741490
SGTC_1865 st057639 52.2 µM 0.0996319024877842 0.440433468821216 no 1440 0.460318282654168 2234 688818
SGTC_3045 9092950 49.47 µM 0.0985853915187859 0.440785182857879 no 1441 0.46073373469527 2245 44120432
SGTC_143 4032-1194 15.74 µM 0.0984082822063276 0.440844710830353 no 1442 0.460804049177135 2149 1806963
SGTC_1434 4073-0095 163 µM 0.0979143497224386 0.4410107328703 no 1443 0.461000152655413 2227 24133745
SGTC_1276 0871-0068 94.2 µM 0.0972936031259054 0.441219394741757 no 1444 0.461246617933612 2209 3414906
SGTC_3086 9117350 49.47 µM 0.096290736380341 0.44155653946278 no 1445 0.461644834098812 2245 2679265
SGTC_615 k087-0205 167 µM 0.0962508242483282 0.441569958040131 no 1446 0.461660683120469 2175 9642773
SGTC_3048 9093155 49.47 µM 0.0955969489199486 0.441789802406122 no 1447 0.46192034425625 2253 25236002
SGTC_2196 6573537 42.6665 µM 0.0952689841618432 0.441900076673339 no 1448 0.462050588813735 2245 2903087
SGTC_2185 6113692 200 µM 0.0952078273218474 0.441920640435158 no 1449 0.462074876463999 2150 874150
SGTC_799 1310-0557 151 µM 0.0946099676100433 0.442121676793598 no 1450 0.462312316172763 2142 5354492
SGTC_1080 nisoldipine 24.4 µM 0.0945865304571006 0.442129558076668 no 1451 0.462321624501367 2224 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1264 0783-0040 158 µM 0.0939733910673597 0.442335748462863 no 1452 0.462565147014664 2160 2855798
SGTC_121 0557-0495 61.343 µM 0.0936885396592309 0.442431545411487 no 1453 0.46267828712982 2225 3104427
SGTC_1727 st034309 9.9045 µM 0.0927639515295174 0.442742512176621 no 1454 0.463045544997566 2250 870305
SGTC_3228 9131799 49.47 µM 0.0921089617294948 0.442962826282369 no 1455 0.463305734146611 2159 17015818
SGTC_578 3460-0051 92 µM 0.0920595524774291 0.442979446425624 no 1456 0.463325362191533 2247 2876744
SGTC_696 1560-0013 611 µM 0.0919389478969955 0.443020015471616 no 1457 0.463373273271831 2205 1650269
SGTC_3053 9095903 49.47 µM 0.09138135739061 0.443207585881856 no 1458 0.463594787205976 2251 17174018
SGTC_1790 st045711 43.5 µM 0.0904791704945745 0.443511103579189 no 1459 0.463953222795437 2241 585119
SGTC_849 0386-0493 241 µM 0.0898049513059462 0.443737949023406 no 1460 0.464221106759319 2133 726119
SGTC_950 1165-0508 94.1 µM 0.0895267103071953 0.443831570400996 no 1461 0.464331663526935 2150 6148369
SGTC_1613 st002381 52.1 µM 0.088810082976712 0.444072712615751 no 1462 0.464616422150722 2270 551167
SGTC_2325 6158266 200 µM 0.0886417366905284 0.444129363470816 no 1463 0.464683318768358 2160 3623240
SGTC_2826 7992541 19.48 µM 0.0884442054921254 0.444195836908225 no 1464 0.464761814015326 2272 2985066
SGTC_1686 st019653 115.5 µM 0.086339963624577 0.444904055987762 no 1465 0.465598085346126 2247 97252
SGTC_1361 1608-0041 5.61 µM 0.0860010895591158 0.445018126433535 no 1466 0.465732775546902 2204 X1361
SGTC_841 0251-0215 91.2 µM 0.0853897946519027 0.445223909612174 no 1467 0.465975753109203 2184 3888614
SGTC_2000 st075254 36.4 µM 0.0843047889922686 0.445589196662215 no 1468 0.46640705244724 2271 17234175
SGTC_2365 9042475 200 µM 0.0804483959138849 0.446887893881558 no 1469 0.467940318615899 2167 6464479
SGTC_1053 3366-3204 134 µM 0.0779087883743953 0.447743456203313 no 1470 0.46895030427526 2176 3632071 YPR165W RHO1
SGTC_3312 9133330 71.43 µM 0.0779066136189852 0.447744188956248 no 1471 0.468951169248132 2239 17617324
SGTC_1171 0368-0077 21.4 µM 0.0776566336188327 0.44782841735314 no 1472 0.469050595619997 2204 3239779
SGTC_1563 conessine 56.1 µM 0.0766422325102252 0.448170234315574 no 1473 0.469454080527566 2268 441082 An anti-amoebic, histamine inhibitor.
SGTC_3309 9129340 25.759 µM 0.0764750762309375 0.448226563714893 no 1474 0.469520571090765 2213 17158987
SGTC_8 0354-0001 70 µM 0.076329478387912 0.448275629064232 no 1475 0.469578486942979 2219 4993152
SGTC_2663 amphotericin b 100 µM 0.07555253996222 0.448537464675845 no 1476 0.469887548052989 2245 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1809 st050081 57.6 µM 0.0752959461617961 0.448623944148222 no 1477 0.469989623411279 2236 5036894
SGTC_1723 st034307 2.5525 µM 0.0752376717729432 0.44864358462946 no 1478 0.470012805770661 2225 867466
SGTC_2071 5230951 39.92 µM 0.0729644958062107 0.449409821166785 no 1479 0.470917185208354 2258 1799272
SGTC_2144 5628481 200 µM 0.0704118164039417 0.450270496815904 no 1480 0.471932943231233 2243 2818399
SGTC_1608 st001473 40.5 µM 0.0701678162009017 0.45035277760047 no 1481 0.472030045058411 2127 7292267
SGTC_2179 6298986 200 µM 0.0700330111949688 0.450398236927426 no 1482 0.472083692499193 2284 738374
SGTC_951 1171-0579 82.7 µM 0.0696319295791892 0.450533494655191 no 1483 0.472243311241382 2279 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2093 5331342 194.4 µM 0.0693045909173236 0.450643888126001 no 1484 0.472373585751566 2278 33839
SGTC_623 k072-0108 16.9 µM 0.0691382093030978 0.450700001030758 no 1485 0.472439803577153 2216 5382803
SGTC_196 k015-0023 18.111 µM 0.0665220247017814 0.451582449223708 no 1486 0.47348111168406 2223 5211998
SGTC_516 3992-2719 87.3 µM 0.0652344768580458 0.452016831741613 no 1487 0.47399365550831 2275 5350887 YDR037W KRS1
SGTC_604 1000-0114 314 µM 0.0650565829554134 0.452076852681862 no 1488 0.474064474472131 2301 1572745
SGTC_1899 st063254 59.6 µM 0.0642278731941947 0.452356471614864 no 1489 0.474394391804865 2273 3093813
SGTC_1391 3442-0225 151 µM 0.0641107263893132 0.452396000589459 no 1490 0.474441030497355 2261 5227075
SGTC_244 nsc-207895 1.295 µM 0.0638387221499901 0.452487785096714 no 1491 0.474549322654441 2278 42640
SGTC_1838 st055369 84.5 µM 0.0633564422138445 0.452650530807528 no 1492 0.47474133580396 2292 676036
SGTC_108 0509-0257 621.132 µM 0.0628650623456946 0.45281635547817 no 1493 0.47493697800071 2277 536624
SGTC_2987 9018338 71.43 µM 0.0616998264134194 0.453209617423648 no 1494 0.475400939104871 2317 5055682
SGTC_1866 st057638 64 µM 0.0611445113174733 0.453397049969895 no 1495 0.47562206026909 2240 688802
SGTC_2090 5301565 104.445 µM 0.0609205266989638 0.453472653245628 no 1496 0.475711250932396 2253 2056344
SGTC_770 0389-1121 67.2 µM 0.0572758652668478 0.454703099275308 no 1497 0.477162722756096 2285 6753108
SGTC_2355 9061122 103.12 µM 0.0568269521431587 0.454854683682967 no 1498 0.477341521959481 2293 5302957
SGTC_1213 1315-0166 115 µM 0.0565452040252453 0.454949824874727 no 1499 0.477453742750675 2124 768401
SGTC_651 3253-0966 34.4 µM 0.0549707592262392 0.455481533534966 no 1500 0.478080879656954 2278 781462
SGTC_788 1182-0090 188 µM 0.0549401501007364 0.455491871392647 no 1501 0.478093072505551 2284 5715185
SGTC_883 0850-0245 24.6 µM 0.054455192089555 0.455655664044814 no 1502 0.478286253559344 2253 6823229 YPR165W RHO1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0510484165316735 0.456806499920519 no 1503 0.479643470000491 2282 4330530
SGTC_3147 9097027 49.47 µM 0.0497762847787786 0.457236329580459 no 1504 0.48015033262781 2264 25236841
SGTC_1574 spiramycin 23.7 µM 0.0495739600743402 0.457304695959411 no 1505 0.480230948980085 2305 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2738 aclarubicin 5.55 µM 0.0486137493321079 0.457629172450431 no 1506 0.480613556269338 2295 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1801 st050089 28.441 µM 0.0473544766453931 0.458054751376063 no 1507 0.481115355330927 2313 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1739 st037196 92.5 µM 0.0470921564687175 0.458143410156894 no 1508 0.481219889317529 2312 612214
SGTC_2606 farnesol 9.78 µM 0.0464416264512818 0.458363284791585 no 1509 0.481479129588858 2314 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3234 9132280 49.47 µM 0.0454923052266465 0.458684171626487 no 1510 0.481857454045058 2236 17612295
SGTC_2883 9059145 45.46 µM 0.045142877644125 0.458802290924956 no 1511 0.481996712411169 2311 16476510
SGTC_2888 9058547 12.99 µM 0.0439304619738772 0.459212159889657 no 1512 0.482479916794611 2318 16476514
SGTC_2248 tofa 1.1 µM 0.0435095765824759 0.459354454469658 no 1513 0.482647665373892 2304 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_112 phenothiazine 287.218 µM 0.0413616263802531 0.460080722589792 no 1514 0.483503802157068 2329 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2119 5528445 120.635 µM 0.0413304132458671 0.460091277409047 no 1515 0.483516243757115 2293 791935
SGTC_1820 st053765 18.6 µM 0.0407115425856744 0.460300556260162 no 1516 0.48376292978646 2294 3690829
SGTC_2755 lomerizine 42.69 µM 0.0406404913711634 0.460324583821558 no 1517 0.483791251680472 2317 3949 A calcium channel blocker.
SGTC_715 0868-0130 184 µM 0.0406336796452745 0.460326887367021 no 1518 0.483793966923067 2328 2876258
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0398459899153823 0.460593272151685 no 1519 0.484107955337137 2334 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_913 3487-1245 167 µM 0.0394787254600748 0.460717481503194 no 1520 0.484254357457548 2307 4016153
SGTC_3145 9085516 49.47 µM 0.0379519517769303 0.461233879444345 no 1521 0.484862995665281 2222 25236195
SGTC_265 mycophenolic acid 32.932 µM 0.0377302567053569 0.461308868429117 no 1522 0.484951375901846 2312 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1094 duloxetine 25.4 µM 0.0366428893199636 0.461676693393089 no 1523 0.485384872872486 2345 60834 A selective serotonin reuptake inhibitor.
SGTC_3001 9076041 71.4286 µM 0.036261366619928 0.461805759282485 no 1524 0.485536977318992 2327 16004211
SGTC_640 3381-0960 37.1 µM 0.0354217017504327 0.462089824925564 no 1525 0.485871740037204 2321 1745025
SGTC_992 3909-8734 162 µM 0.0336728303956448 0.462681544640795 no 1526 0.486569022442606 2333 4288319
SGTC_2524 avocatin b 10.57 µM 0.0335816972418763 0.462712381250307 no 1527 0.486605358760545 2327 6710748
SGTC_2267 7931562 200 µM 0.0326621586695656 0.463023536855677 no 1528 0.486972000393099 2335 934880
SGTC_3166 9102297 49.47 µM 0.03248529267551 0.463083387783198 no 1529 0.487042522292529 2302 25237072
SGTC_1985 st071382 65.5 µM 0.032380474211694 0.463118858434762 no 1530 0.487084316822047 2353 6123237
SGTC_3204 9114183 49.47 µM 0.0323378513376346 0.463133282133139 no 1531 0.48710131198834 2339 17027248
SGTC_1910 st062352 60.4 µM 0.0322921484826867 0.463148748159407 no 1532 0.487119535272112 2342 2245730
SGTC_1199 1638-0010 4.46 µM 0.0304530400634156 0.463771155665336 no 1533 0.487852872296991 2333 3111136
SGTC_180 1486-1293 102.781 µM 0.0303434881398072 0.463808234019962 no 1534 0.487896557003009 2357 4140536
SGTC_1875 nocodazole 6 µM 0.0283387990453055 0.464486785486515 no 1535 0.488695967926477 2362 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2186 6124449 200 µM 0.0277061418613127 0.464700950185127 no 1536 0.488948262544226 2342 3834182 YLR033W RSC58
SGTC_1140 3229-1848 2.98 µM 0.0275845878267519 0.464742099366708 no 1537 0.488996737060679 2336 2849525
SGTC_423 5-fluorouracil 457 µM 0.0272437568940217 0.464857481453859 no 1538 0.48913265784522 2363 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2906 7926292 26.41 µM 0.0265464371872605 0.465093555501266 no 1539 0.489410747557807 2316 2966319
SGTC_1246 0422-0085 105 µM 0.025664936638326 0.465392000610344 no 1540 0.489762295573986 2352 264295
SGTC_2349 9023730 187.07 µM 0.0242597157166656 0.465867799216522 no 1541 0.490322722933531 2354 4126287
SGTC_2177 5811945 192 µM 0.0241327913803516 0.465910777378739 no 1542 0.490373343597342 2341 5343475
SGTC_2957 9076800 11.52 µM 0.0211849177181319 0.466909074948502 no 1543 0.491549072750538 2350 16459615
SGTC_3095 9117207 49.47 µM 0.0193484338497052 0.467531105962762 no 1544 0.492281573261614 2374 17015229
SGTC_652 0437-0092 114 µM 0.0193139544064518 0.467542785174768 no 1545 0.492295325999426 2364 3091274
SGTC_2499 avocadenofuran 51.48 µM 0.0188930938922271 0.467685345386004 no 1546 0.492463194417329 2377 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_442 cape 100 µM 0.018805612022716 0.46771497908317 no 1547 0.492498088434395 2366 5281787
SGTC_1399 3562-5772 25 µM 0.0178557993583478 0.468036731070157 no 1548 0.492876945194352 2375 23847490
SGTC_389 tpck 16.7 µM 0.015263829374091 0.468914874575853 no 1549 0.493910849549026 2359 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_205 1486-1330 71.903 µM 0.0148906369675458 0.469041322426676 no 1550 0.494059714856645 2370 4118834
SGTC_1086 cerivastatin 2.18 µM 0.0143338615714714 0.469229979044259 no 1551 0.494281812387801 2386 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1113 artemisinin 1.17947 µM 0.0117327431683842 0.470111427441075 no 1552 0.495319420071257 2384 2240 An anti-malaria and mitochondrial poison.
SGTC_3275 9138069 49.47 µM 0.0106810517040719 0.47046785894938 no 1553 0.495738957896315 2303 17617007
SGTC_342 k048-0088 23.3 µM 0.0103628104096857 0.470575719616207 no 1554 0.495865910775743 2388 6820570
SGTC_3117 9124945 49.47 µM 0.00967674677005913 0.470808252655073 no 1555 0.496139596824437 2388 17592065
SGTC_1376 2910-0861 41.3 µM 0.00959907822730579 0.470834578104402 no 1556 0.496170580650923 2386 1112859
SGTC_90 0870-0863 4.608 µM 0.0086724615941911 0.471148660993037 no 1557 0.496540231764086 2384 1738164
SGTC_357 1325-0123 420 µM 0.00765441787477812 0.471493754384828 no 1558 0.496946358896783 2397 1098503
SGTC_1223 0764-0573 147 µM 0.00706907657755269 0.47169218132157 no 1559 0.497179869957688 2390 1609797
SGTC_2024 5144227 134 µM 0.00640130758695488 0.471918559294492 no 1560 0.497446265194342 2395 3475211
SGTC_1773 st048542 73.5835 µM 0.00594813036647274 0.472072194452384 no 1561 0.497627053300059 2383 3237138
SGTC_2736 butenafine 14.65 µM 0.00560686451427696 0.472187892405251 no 1562 0.497763196404485 2387 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2505 galangin 7.89 µM 0.00483384798245716 0.472449973671901 no 1563 0.498071581172701 2384 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2129 girgensonine 121.053 µM 0.00463939004278325 0.472515904005853 no 1564 0.498149157796232 2392 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2350 9023895 38.85 µM 0.0041257578666355 0.472690052946445 no 1565 0.498354065417785 2391 2997209
SGTC_819 1013-0258 27.7 µM 0.00393584904689917 0.472754443576947 no 1566 0.498429827459815 2398 5753198
SGTC_1426 4048-4480 71.7 µM 0.00387349969811554 0.472775583950439 no 1567 0.498454701061578 2397 14224343
SGTC_2476 5806916 10.51 µM 0.00240141058268008 0.473274737435251 no 1568 0.499041976706749 2402 2870194
SGTC_897 1000-0139 31.4 µM 0.00128781922095935 0.473652360031995 no 1569 0.499486234605257 2390 6151020
SGTC_716 1683-5115 658 µM 0.000820902408426903 0.473810700166699 no 1570 0.499672507357977 2403 723597
SGTC_2147 5545932 89.7195 µM 0.000244218269158307 0.474006270142188 no 1571 0.499902571007755 2402 797404
SGTC_1687 st020778 55.3625 µM 0 0.474089093386593 no 1572 0.5 2405 4259299
SGTC_2958 9077254 16.72 µM -0.000132984110711944 0.474134193577558 no 1573 0.499946947015772 2406 16457351
SGTC_1037 k284-1091 78.7 µM -0.000536462509351985 0.474271031145568 no 1574 0.499785982433435 2387 3334711
SGTC_3232 9132874 49.47 µM -0.000606337233936876 0.474294729098196 no 1575 0.499758106456023 2406 3784940
SGTC_2013 4024628 200 µM -0.00135663871622293 0.474549198914175 no 1576 0.499458779622886 2415 5230760
SGTC_1714 st033236 13.627 µM -0.00180587050925912 0.474701563887686 no 1577 0.499279562292505 2417 2916566
SGTC_1016 4226-1401 38 µM -0.00186231846165042 0.474720709479484 no 1578 0.499257042855533 2404 2901613
SGTC_1131 3454-3128 32.3 µM -0.00280802829832554 0.475041476874185 no 1579 0.49887976025942 2416 710982
SGTC_1179 1021-1431 9.29 µM -0.00327969623002367 0.475201464027043 no 1580 0.498691592852598 2416 2840958
SGTC_1294 1000-1494 117 µM -0.0036163055482672 0.47531564249202 no 1581 0.498557305962458 2414 712797 YDL207W GLE1
SGTC_1636 st007707 68.9 µM -0.00377864930048055 0.47537071049972 no 1582 0.498492540618529 2415 403051
SGTC_641 4092-0595 30 µM -0.00399183403622946 0.47544302479877 no 1583 0.498407492855968 2411 786260
SGTC_2915 7971052 15.16 µM -0.00500779211484869 0.475787658557412 no 1584 0.49800218834411 2419 5741558
SGTC_1042 0350-0096 82 µM -0.00552579601965596 0.47596338306482 no 1585 0.497795537553555 2413 3122515
SGTC_2614 arthonioic acid 13.39 µM -0.00646540621130727 0.476282142642911 no 1586 0.497420694072152 2418 6710684
SGTC_252 miconazole 1.30953 nM -0.00648347346795455 0.47628827204798 no 1587 0.497413486430652 2417 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_377 3970-0964 33.1 µM -0.0074235900715597 0.476607218905303 no 1588 0.497038443249857 2419 16481235
SGTC_1105 epirubicin 18.1 µM -0.0094519773160707 0.477295426599135 no 1589 0.496229262761507 2419 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1567 st069303 68.4 µM -0.0094778225507298 0.477304196021481 no 1590 0.496218952466485 2430 5581319
SGTC_2286 7945697 125 µM -0.00977132309246134 0.477403783049594 no 1591 0.496101868114516 2430 1245733
SGTC_1682 st012968 530 nM -0.010176595392093 0.47754129742708 no 1592 0.495940195901989 2429 24207270
SGTC_1210 3013-0140 750 nM -0.0131429354126603 0.478547897122127 no 1593 0.494756878322373 2437 905973
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0134983633260844 0.478668517562206 no 1594 0.494615095680313 2443 65057 A dermal irritant. YDR527W RBA50
SGTC_3039 9090270 49.47 µM -0.0138262201243268 0.478779783013237 no 1595 0.494484311948661 2429 17173750
SGTC_919 tnp00227 403.569 nM -0.0147824327089743 0.479104304302634 no 1596 0.494102877359501 2450 1269246 A methoxyflavone. YNL221C POP1
SGTC_31 0508-1974 57.237 µM -0.0157321679114002 0.479426640998247 no 1597 0.493724031943676 2432 6810525
SGTC_2939 9044578 71.43 µM -0.0161385661558983 0.479564575216744 no 1598 0.493561923086318 2437 2653634
SGTC_1492 4158-0558 28.5 µM -0.0164298718187717 0.479663447768072 no 1599 0.493445724348856 2445 3967268
SGTC_1045 1348-1485 165 µM -0.01686269163344 0.479810354187728 no 1600 0.493273078148012 2440 6810614
SGTC_1303 1160-0052 261 µM -0.0169246506014974 0.479831384342028 no 1601 0.493248363622974 2437 3562476
SGTC_3080 9117754 49.47 µM -0.0178148010721092 0.480133525977445 no 1602 0.492893298542966 2427 9550191
SGTC_1129 3453-1384 223 µM -0.0187310069625654 0.480444523460203 no 1603 0.492527846305655 2510 1084452
SGTC_1581 himbacine 57.9 µM -0.0198272764955444 0.480816657481159 no 1604 0.492090579330533 2441 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2557 derrustone 83.84 µM -0.0204605833058507 0.481031644195342 no 1605 0.491837977726931 2482 629853 An antioxidant.
SGTC_707 0865-0008 204 µM -0.020676865815974 0.481105066220462 no 1606 0.49175171173961 2447 723043
SGTC_2360 9040895 200 µM -0.021318819726781 0.481322995864599 no 1607 0.491495665639704 2458 4914414
SGTC_1025 k007-0731 70 µM -0.0219770249871719 0.481546448289746 no 1608 0.491233141257831 2453 6256118
SGTC_345 1362-0200 395 µM -0.0232909952197667 0.481992541962815 no 1609 0.49070907727032 2460 1419823
SGTC_2761 levamisole 97.89 µM -0.0235921036112457 0.482094771635947 no 1610 0.490588985402577 2458 26879 An alkaline phosphatase inhibitor.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.023701983154544 0.482132077265769 no 1611 0.490545162061365 2455 5024745
SGTC_2534 helenine 20.12 µM -0.024505019901188 0.482404724114645 no 1612 0.490224889808223 2456 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2610 ononetin 44.17 µM -0.0259447458340081 0.48289356004552 no 1613 0.489650705015442 2469 259632
SGTC_2570 licareol 100 µM -0.0274624926609582 0.483408914555003 no 1614 0.489045427538402 2505 443158
SGTC_1531 st059297 52.4 µM -0.030622977413191 0.484482152560521 no 1615 0.48778510870774 2501 7566702
SGTC_2214 7179297 48.276 µM -0.0331824340488144 0.485351376079092 no 1616 0.486764553003461 2458 769744
SGTC_481 bay k-8644 50 µM -0.0333758231066161 0.485417056304562 no 1617 0.486687444642452 2457 2303 A calcium channel antagonist.
SGTC_2521 angolensin 13.4 µM -0.0359550389699403 0.486293065840571 no 1618 0.485659104728796 2527 821428 A flavenoid.
SGTC_1941 st076221 61.8 µM -0.0366694719954504 0.486535729043201 no 1619 0.485374275041724 2466 2828568
SGTC_2095 5432005 200 µM -0.0367033059836554 0.486547221166999 no 1620 0.48536078631355 2489 783734
SGTC_2224 6650123 117.647 µM -0.0373545085034014 0.486768412153891 no 1621 0.485101172144609 2470 2908370
SGTC_812 4251-0442 148 µM -0.0397185389060311 0.487571425277913 no 1622 0.484158760714482 2464 5723007
SGTC_3068 9116768 49.47 µM -0.039894968721755 0.487631356964703 no 1623 0.484088431144968 2516 41904888
SGTC_1724 st037281 8.293 µM -0.0404821734534202 0.48783082735202 no 1624 0.48385435945704 2475 574124 YDL195W SEC31
SGTC_839 0122-0028 230 µM -0.0408191300746061 0.487945291138126 no 1625 0.483720044236986 2485 759448
SGTC_499 genistein 192 µM -0.0409068098350829 0.487975076017562 no 1626 0.483685094265014 2465 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1443 4112-3303 14 µM -0.0416612938108568 0.488231377535995 no 1627 0.483384355109391 2487 704433
SGTC_873 0591-4978 488 µM -0.0424413087167641 0.488496357132052 no 1628 0.483073449202827 2489 3305145
SGTC_1364 1653-0028 37.6 µM -0.0426464756145641 0.488566055419794 no 1629 0.48299167349271 2528 5718652
SGTC_2110 5483698 200 µM -0.0431595083442075 0.488740341894826 no 1630 0.482787191326251 2514 2848765 YHR062C RPP1
SGTC_565 1418-0001 44.5 µM -0.0450503602673348 0.489382716719113 no 1631 0.4820335839924 2527 2862145
SGTC_683 panaxydol 45 µM -0.0455444616572182 0.489550581267204 no 1632 0.481836668184223 2551 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_325 2810-4341 181 µM -0.0458950319745143 0.489669684116525 no 1633 0.481696956958302 2495 774970
SGTC_637 1181-0519 7.26 µM -0.0464280963747026 0.489850789313999 no 1634 0.481484521492327 2489 6252091 YGR060W ERG25
SGTC_3210 9128157 49.47 µM -0.0467011297180728 0.489943551447017 no 1635 0.481375714972586 2607 17590849
SGTC_2797 7859098 81.82 µM -0.0475255911573558 0.490223662646922 no 1636 0.481047167291114 2510 972681
SGTC_2523 spermine 47.74 µM -0.0485359914028199 0.490566953213559 no 1637 0.480644540619322 2504 1103 A DNA binding polyamine.
SGTC_2575 plumbagin 510 nM -0.0497093571244282 0.490965621194984 no 1638 0.480176999886394 2492 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1 0258-0098 57.368 µM -0.0520034088165576 0.49174508415585 no 1639 0.47926298862416 2482 6790032 YDR047W HEM12
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0523039260182791 0.491847194989793 no 1640 0.479143262545397 2516 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2303 7774051 200 µM -0.0538003978093181 0.492355679470423 no 1641 0.478547096287144 2552 2953184
SGTC_816 0325-0417 81.3 µM -0.0541051924008922 0.492459246834271 no 1642 0.478425677685814 2541 68101
SGTC_2478 5763493 32.33 µM -0.054148860471389 0.492474085023036 no 1643 0.478408282147023 2511 1365576 YLR208W SEC13
SGTC_530 4358-1714 28 µM -0.0550515475769539 0.492780815823347 no 1644 0.478048698498702 2619 1564641
SGTC_2819 7996655 46.38 µM -0.0553062256891061 0.492867355583002 no 1645 0.477947251188556 2519 6456960
SGTC_170 4197-0004 226 µM -0.0554559001109179 0.492918215189016 no 1646 0.477887631232651 2568 218692
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0571038853610862 0.493478210621397 no 1647 0.477231220702662 2512 641818 YHR062C RPP1
SGTC_2916 7875993 68.79 µM -0.0574744873633516 0.493604145250028 no 1648 0.477083614320286 2513 1299250
SGTC_1911 st060208 74.3 µM -0.0591734352239519 0.494181474350592 no 1649 0.476406984088261 2588 688783
SGTC_3320 9137005 35.139 µM -0.0595739961249979 0.494317593040697 no 1650 0.476247464829653 2552 4908713
SGTC_483 fpl-64176 144 µM -0.0598371986664784 0.494407034945192 no 1651 0.476142649195645 2519 3423
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.0598690544546964 0.49441786024876 no 1652 0.476129963318136 2497 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_878 0828-0289 13.7 µM -0.0601602005588399 0.494516798343589 no 1653 0.476014021812428 2535 745350 YLR208W SEC13
SGTC_1412 3909-8563 178 µM -0.0602816620072243 0.494558073817512 no 1654 0.475965653490148 2517 23767530
SGTC_2624 nerol 100 µM -0.0605437141356275 0.494647125528721 no 1655 0.475861300418945 2508 637566 A natural product oil.
SGTC_2897 9048598 12.99 µM -0.0607088148894203 0.494703230933033 no 1656 0.47579555568273 2536 6467404
SGTC_1018 4259-0013 28.1 µM -0.0621106353641354 0.495179609030862 no 1657 0.475237363778285 2650 6801262
SGTC_2874 9043904 71.43 µM -0.0633722956668511 0.495608362649652 no 1658 0.474735023875326 2586 4463428
SGTC_2946 9065502 71.43 µM -0.0634746516398302 0.495643146800985 no 1659 0.474694271795925 2503 16489101
SGTC_2114 5491910 81.25 µM -0.0643995242873911 0.495957452450585 no 1660 0.474326054402994 2583 2849228
SGTC_553 k007-0256 45.7 µM -0.0653608589301802 0.496284151880619 no 1661 0.473943343730012 2560 6287000
SGTC_1206 3978-0017 132 µM -0.0654831982055468 0.496325727775202 no 1662 0.473894641755389 2760 3873677
SGTC_1874 staurosporine 7.6 µM -0.0655215975063239 0.496338777438 no 1663 0.473879355479346 2584 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2793 7325131 81.82 µM -0.0655536121497907 0.496349657334467 no 1664 0.473866610884037 2583 4176441
SGTC_1762 st045503 25.4615 µM -0.0662639423304757 0.496591057515005 no 1665 0.473583844978178 2568 4645554
SGTC_2228 7354201 200 µM -0.0664812086283058 0.496664894027832 no 1666 0.4734973589752 2552 753451
SGTC_2072 5231554 129 µM -0.0665212200240504 0.496678491648298 no 1667 0.473481431994538 2566 789545
SGTC_472 calcifediol 10 µM -0.0673046617198856 0.49694474012476 no 1668 0.4731695828953 2591 5283731 A vitamin D metabolite.
SGTC_1121 fusaric acid 630.51 nM -0.0686742725872627 0.497410198261876 no 1669 0.472624448672211 2566 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_889 0919-1524 82.7 µM -0.0692424076497608 0.497603278326228 no 1670 0.472398333834062 2584 3905452
SGTC_3236 9132701 49.47 µM -0.0697430838136314 0.49777343302634 no 1671 0.47219907466228 2538 24282524
SGTC_2443 5493264 126.67 µM -0.0712301451283039 0.498278812802688 no 1672 0.471607295000229 2593 5340055
SGTC_1506 4226-2149 212 µM -0.0721131574165661 0.498578907068667 no 1673 0.471255927691938 2600 991114
SGTC_504 lovastatin 124 µM -0.0730219449751991 0.498887761972368 no 1674 0.470894327280693 2539 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3344 9148862 3.898 µM -0.0738484072249924 0.499168638890801 no 1675 0.470565504377594 2600 4905352
SGTC_2487 5918373 44.05 µM -0.0739091431930701 0.499189280301092 no 1676 0.470541340266801 2520 2876279
SGTC_1964 st076914 61 µM -0.0740631552082384 0.499241622033325 no 1677 0.470480066297364 2520 24208661
SGTC_1672 st016598 6.51 µM -0.076250396739515 0.499984967684303 no 1678 0.469609944279512 2616 4665860 YNL267W PIK1
SGTC_847 0342-0274 5.54 µM -0.0763388597175773 0.499984967684303 no 1679 0.469574755221975 2574 18097
SGTC_3113 9123498 49.47 µM -0.0764649018539721 0.499942131568711 no 1680 0.469524618229453 2527 8897275
SGTC_1251 0490-5699 265 µM -0.0767228203698565 0.49985447654043 no 1681 0.469422025008354 2554 3883818
SGTC_1659 st012954 42.1 µM -0.0769348214529428 0.499782426809679 no 1682 0.469337698057584 2630 24207262
SGTC_2361 9034121 116 µM -0.080300113875269 0.498638716234784 no 1683 0.467999283824313 2586 6496917
SGTC_1860 st056228 74.6 µM -0.0811426697310654 0.498352371018641 no 1684 0.467664246003443 2663 688679
SGTC_828 2074-0507 139 µM -0.0817034512953781 0.498161788129207 no 1685 0.467441266900641 2638 X828
SGTC_445 e6 berbamine 66 µM -0.0820078110853626 0.498058350935549 no 1686 0.467320251016356 2622 6610268 A calcium/calmodulin antagonist.
SGTC_171 k064-0041 9.68 µM -0.0831200782839649 0.497680346193777 no 1687 0.466878030463681 2566 53325
SGTC_3011 9081274 71.4286 µM -0.0838731759541679 0.497424406615038 no 1688 0.466578633441059 2594 6625322
SGTC_199 4063-0024 41.6 µM -0.0845509720863093 0.49719405910096 no 1689 0.466309189013397 2655 306215
SGTC_1011 4112-3381 17.4 µM -0.0851973639814884 0.496974385117618 no 1690 0.46605224310077 2713 2877139
SGTC_2907 7721985 69.9 µM -0.0859073988003348 0.496733083373215 no 1691 0.465770014932699 2597 3267881
SGTC_1233 0325-0408 14.2 µM -0.0860019828365802 0.496700939554849 no 1692 0.465732420496209 2637 12874
SGTC_1158 4092-0494 91.8 µM -0.086278639061724 0.496606919717017 no 1693 0.4656224593532 2679 1148199
SGTC_44 0929-0055 61.211 µM -0.0863166047752624 0.496594017328169 no 1694 0.465607369518717 2567 1379590
SGTC_2974 9094440 9.66 µM -0.0869974498378995 0.496362637394259 no 1695 0.465336769578931 2780 25236134
SGTC_2105 5350118 200 µM -0.0871987792124136 0.496294217392833 no 1696 0.465256754854717 2593 2133313
SGTC_1845 st056753 3.01 µM -0.0874720969562841 0.496201332957696 no 1697 0.465148131901618 2525 5375839
SGTC_67 0335-0847 266 µM -0.0878103963126821 0.496086365425468 no 1698 0.465013687311963 2898 4552207 YOR254C SEC63
SGTC_2729 fluphenazine 10.66 µM -0.0886013854161454 0.495817557256667 no 1699 0.464699353507318 2573 3372 An atypical antipsychotic.
SGTC_1685 st024049 53.0905 µM -0.0904449671226313 0.495191045685493 no 1700 0.463966812248854 2629 1941139
SGTC_2272 7805186 180 µM -0.0904487811110246 0.495189749574684 no 1701 0.463965296898586 2553 2956062 YPR165W RHO1
SGTC_322 k048-0136 19.3 µM -0.0909952531166367 0.495004042075629 no 1702 0.463748181436865 2657 6823282
SGTC_2470 5664817 21.68 µM -0.0913093957215332 0.494897287529199 no 1703 0.463623376236067 2559 2859561
SGTC_2925 9010536 32.5 µM -0.0915498970914414 0.494815558604811 no 1704 0.463527830259668 2623 2994177
SGTC_1837 st055472 66.5 µM -0.0922099760700016 0.494591246894876 no 1705 0.463265606029056 2710 676091
SGTC_2376 9072922 81.32 µM -0.0927247348951511 0.494416319870987 no 1706 0.463061123029508 2699 17087968
SGTC_22 0964-0034 14.468 µM -0.0933315658543799 0.494210105975489 no 1707 0.46282007779767 2599 138402
SGTC_1329 1447-1697 50.6 µM -0.0941538313815173 0.493930685371506 no 1708 0.462493479502461 2701 2840515
SGTC_2791 5663188 71.43 µM -0.0945663820844052 0.493790494341496 no 1709 0.462329626670443 2664 54690634
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0945917493426889 0.493781874184531 no 1710 0.462319551760536 2564 688667
SGTC_1738 st035555 74 µM -0.0949048098295104 0.493675491996501 no 1711 0.462195218037538 2661 5331140
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0949808085728319 0.493649666663086 no 1712 0.462165035268408 2683 5282362
SGTC_733 4069-0007 56.1 µM -0.0954759518473838 0.493481411377481 no 1713 0.461968395317001 2583 5717425 YNL287W SEC21
SGTC_533 1222-0222 6.71 µM -0.0967319972826519 0.493054598201595 no 1714 0.461469614409777 2758 3982874
SGTC_3015 9080845 49.47 µM -0.0973666382930398 0.492838945663753 no 1715 0.461217618799913 2675 5296973
SGTC_1007 4101-0031 70 µM -0.0976860574210512 0.492730407065599 no 1716 0.461090793583526 2580 1146276
SGTC_278 4092-0821 23.9 µM -0.0977380710238293 0.492712732897627 no 1717 0.461070141981029 2662 877900
SGTC_1436 4092-1007 8.32 µM -0.0988465329604667 0.4923360821446 no 1718 0.460630060709214 2596 2881121
SGTC_2004 4023728 41.89 µM -0.0989350326008791 0.492306010625204 no 1719 0.460594926676213 2618 360084 YDR527W RBA50
SGTC_259 usnic acid 108.925 µM -0.0995158201348751 0.492108664435021 no 1720 0.460364363799317 2746 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3223 9129970 49.47 µM -0.0997857104664988 0.492016958870544 no 1721 0.460257226409951 2611 17248386
SGTC_2227 7312221 64.1025 µM -0.0998075100924291 0.49200955163207 no 1722 0.460248572817079 2592 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2567 aureobasidin a 60 nM -0.099907205933126 0.491975676275541 no 1723 0.460208997735058 2823 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1235 benzylparaben 21.5 µM -0.101808596138839 0.491329619847758 no 1724 0.459454301187713 2649 7180
SGTC_109 0132-0036 33.701 µM -0.103132094313759 0.490879933526082 no 1725 0.458929066623684 2575 67274 A color developer.
SGTC_718 1130-0073 349 µM -0.103154907443192 0.490872182385862 no 1726 0.458920013784791 2671 6740020
SGTC_1940 st075990 51.1 µM -0.103264927281398 0.490834801364105 no 1727 0.458876355370994 2840 1084979
SGTC_1786 berberine 21.6 µM -0.103585218805172 0.490725977591385 no 1728 0.458749259119834 2578 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_323 4013-0906 34.3 µM -0.103937844074924 0.490606168749905 no 1729 0.45860933725363 2699 2910086
SGTC_443 clozapine 122 µM -0.104981341376984 0.490251632509244 no 1730 0.458195307160581 2575 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2277 7947813 106.88 µM -0.105971662403919 0.489915170436131 no 1731 0.457802417841898 2831 1246798
SGTC_1573 oleylamine 1.06 µM -0.108444860575153 0.489074931959297 no 1732 0.456821408671583 2586 5356789 An amine of the fatty acid oleic acid.
SGTC_1839 st053978 48 µM -0.108513130257666 0.489051738849905 no 1733 0.456794332788694 2583 3788398
SGTC_3242 9133940 49.47 µM -0.108697587268139 0.488989073859982 no 1734 0.456721177799203 2753 17248444
SGTC_3322 9139058 2.11 µM -0.110216188907974 0.488473174656532 no 1735 0.456118961800195 2745 4908926 YPR165W RHO1
SGTC_1862 st057513 3.81 µM -0.110561392816803 0.488355904677052 no 1736 0.455982081899809 2622 5393163
SGTC_1259 0671-0132 43 µM -0.111553262734199 0.488018960001884 no 1737 0.455588815781587 2633 X1259
SGTC_2706 st078239 82.5 µM -0.112034627077992 0.487855440464391 no 1738 0.455397975478452 2616 15434492
SGTC_2191 5911152 200 µM -0.112456952962272 0.487711977980575 no 1739 0.455230549864902 2620 2875902
SGTC_1670 st016595 4.04 µM -0.116108384910127 0.486471668822209 no 1740 0.453783321782664 2598 597879
SGTC_1159 4092-0538 61.2 µM -0.116233581389973 0.48642914465065 no 1741 0.453733711508162 2616 717301
SGTC_1034 k072-0165 12.7 µM -0.116895945878061 0.486204168850664 no 1742 0.453471255424589 2674 5835461
SGTC_3351 9150312 21.596 µM -0.117966508222917 0.485840555681862 no 1743 0.453047097555583 2595 4904905
SGTC_2926 9010726 65.15 µM -0.118387161778074 0.485697685215783 no 1744 0.452880448829093 2707 2994293
SGTC_3132 9126706 49.47 µM -0.118418989044731 0.485686875500671 no 1745 0.452867840278692 2834 850858
SGTC_560 2332-1943 155 µM -0.118940115940963 0.485509883063645 no 1746 0.452661399700826 2604 21177716
SGTC_710 3448-4187 58 µM -0.118971767748918 0.485499133123601 no 1747 0.452648861482084 2630 3946412
SGTC_2266 7929956 200 µM -0.11922254459705 0.485413961866562 no 1748 0.45254952301383 2601 2967153
SGTC_3215 9129942 49.47 µM -0.119612756101349 0.485281435788545 no 1749 0.452394957184751 2660 17682944
SGTC_2319 6033012 152.6 µM -0.120549129701629 0.484963425373651 no 1750 0.452024081747789 2654 847246
SGTC_1456 k015-0012 13 µM -0.121229727402545 0.484732287344817 no 1751 0.451754539348197 2613 2989616
SGTC_2089 5281248 129.67 µM -0.121360358560017 0.484687924235078 no 1752 0.451702807015199 2625 2737878
SGTC_689 0833-0039 98 µM -0.121640779015866 0.484592692439051 no 1753 0.451591758145238 2694 5374726
SGTC_448 monastrol 171 µM -0.122019702420337 0.48446401008426 no 1754 0.45144170729432 2655 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1916 st067606 49.2 µM -0.122200932124327 0.484402465063919 no 1755 0.451369944130181 2739 19590279
SGTC_2136 5328288 199.296 µM -0.122615302145417 0.484261747745656 no 1756 0.451205868262022 2656 262395
SGTC_974 1326-0144 138 µM -0.122882685393186 0.484170947202727 no 1757 0.451099998379126 2645 5411856
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.123435040820078 0.483983375705106 no 1758 0.450881305333199 2621 17037758
SGTC_918 glabranin 770.725 nM -0.12398531379761 0.483796514899933 no 1759 0.450663451613224 2671 124049 Also referred to as licorice root.
SGTC_1189 1431-2119 7.28 µM -0.125071607768246 0.483427643441355 no 1760 0.450233430243419 2615 3107275
SGTC_1526 st051518 75 µM -0.12540488117893 0.483314477042953 no 1761 0.450101512000416 2705 673993
SGTC_3248 9135562 49.47 µM -0.126020832241735 0.48310532809856 no 1762 0.449857717147005 2654 17650701
SGTC_52 0329-0193 875 nM -0.126189347214055 0.48304810889183 no 1763 0.44979102182463 2849 3739292
SGTC_954 1189-0853 2.85 µM -0.12628372942407 0.483016061594071 no 1764 0.449753667591694 2599 2828194
SGTC_512 prima-1 270 µM -0.126534394094587 0.482930949420894 no 1765 0.449654462641851 2789 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1195 1502-0147 41.1 µM -0.126730951756774 0.48286420960708 no 1766 0.44957667369243 2634 817940
SGTC_3282 9108498 15.4605 µM -0.126788303122918 0.482844736432207 no 1767 0.449553976888251 2724 16459645
SGTC_2769 toremifene 3.73 µM -0.126903480074248 0.482805629189036 no 1768 0.449508396106305 2772 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1232 0279-0259 161 µM -0.127905862375637 0.482465286796153 no 1769 0.449111735825826 2639 1560000
SGTC_140 0062-0056 502.533 µM -0.13027395329417 0.481661291744848 no 1770 0.448174843347382 2616 3758964
SGTC_2062 5245942 200 µM -0.130354602708505 0.481633911603542 no 1771 0.448142940919893 2612 1376160
SGTC_2563 tomatine 8.54 µM -0.132116765755459 0.481035686415384 no 1772 0.447445967500285 2605 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2681 menadione 3.18 µM -0.132640471233948 0.480857905244405 no 1773 0.447238861887757 2689 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3122 9126309 49.47 µM -0.132828956416624 0.480793921515186 no 1774 0.447164326679298 2625 17591206
SGTC_1059 3448-6867 171 µM -0.132898974097588 0.480770153235179 no 1775 0.447136639129529 2616 3934407
SGTC_73 0327-0325 16.231 µM -0.134334843585133 0.480282746575764 no 1776 0.446568900869546 2822 53298
SGTC_3271 9137798 49.47 µM -0.134501282119294 0.480226250819639 no 1777 0.446503098658854 2655 6498326
SGTC_2831 7999036 19.48 µM -0.134534971535409 0.480214815360853 no 1778 0.446489779578374 2917 2988270
SGTC_734 2023-0417 80 µM -0.135328544315517 0.479945451550872 no 1779 0.446176058781786 2764 3935732
SGTC_921 1561-0023 372 µM -0.136616381686013 0.479508338182139 no 1780 0.445667013600626 2627 24050882
SGTC_518 1021-0119 62.6 µM -0.137663977400535 0.479152784968817 no 1781 0.445252995071414 2708 1097762
SGTC_970 1315-0089 19.5 µM -0.137807087764675 0.479104214698259 no 1782 0.445196441291785 2639 6811083 YLR033W RSC58
SGTC_731 3966-0296 387 µM -0.139740601919762 0.47844802944419 no 1783 0.444432472716873 2660 660956
SGTC_2931 9014674 55.67 µM -0.142357391496231 0.477560051347533 no 1784 0.443398858104462 2694 2996810
SGTC_1374 2889-5571 141 µM -0.142731422629218 0.477433137087918 no 1785 0.443251149559063 2716 2853281
SGTC_624 k048-0052 28 µM -0.143974357585504 0.477011407504158 no 1786 0.442760359165155 2730 6835531
SGTC_3153 9100258 49.47 µM -0.14414586922868 0.476953215372478 no 1787 0.442692642252796 2697 25236848
SGTC_2338 7999974 200 µM -0.14458933855288 0.476802753085629 no 1788 0.442517557687394 2771 315925
SGTC_3185 9108267 49.47 µM -0.144610967269611 0.47679541488077 no 1789 0.44250901881659 2722 4910486
SGTC_1027 k015-0025 8.67 µM -0.144964714802667 0.4766753963099 no 1790 0.442369365480999 2647 3598955
SGTC_763 3453-1109 128 µM -0.146632696060714 0.47610951652483 no 1791 0.441710972447234 2651 1560353
SGTC_57 miconazole 162.5 nM -0.147138314229997 0.475937989827807 no 1792 0.441511424297585 2625 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2845 9003024 42.97 µM -0.147901313399714 0.475679157249681 no 1793 0.441210325832304 2892 2990173
SGTC_3125 9127534 49.47 µM -0.149313171812636 0.475200238981976 no 1794 0.440653261089401 2635 1639235
SGTC_2088 5278280 127.392 µM -0.149414679498498 0.475165807804582 no 1795 0.440613214592817 2747 791502
SGTC_3177 9107506 49.47 µM -0.14989497615794 0.475002894783499 no 1796 0.440423737690961 2733 8897194
SGTC_2841 9004761 38.96 µM -0.151109206492422 0.474591055669914 no 1797 0.439944785083232 2695 2991039
SGTC_2391 6285546 200 µM -0.153574722199732 0.473754893220228 no 1798 0.438972534610922 2649 846083
SGTC_1395 3486-0190 4.35 µM -0.155020039075913 0.473264777602048 no 1799 0.438402759689029 2736 6748079
SGTC_842 0271-0008 11.1 µM -0.156857934945442 0.472641594641066 no 1800 0.437678406218128 2788 1221709
SGTC_2827 7993847 71.43 µM -0.157715805766522 0.472350735659789 no 1801 0.4373403725883 2785 2985692
SGTC_363 0455-0021 3.06 µM -0.158238271275777 0.472173602234349 no 1802 0.437134523760447 2695 4597466
SGTC_1043 0916-0009 19.3 µM -0.158443154221579 0.47210414150727 no 1803 0.437053805534785 2689 3101130
SGTC_1720 st037298 9.481 µM -0.158751078543742 0.471999748629965 no 1804 0.436932496780266 2779 597396
SGTC_1305 1181-0477 144 µM -0.159505442471366 0.471744011399029 no 1805 0.436635335371145 2819 6252086
SGTC_2198 6589944 200 µM -0.159937138229619 0.471597667273442 no 1806 0.436465296495569 2721 5290268
SGTC_200 k038-0079 37.545 µM -0.1621582290506 0.470844782325721 no 1807 0.435590626380989 2731 3436683
SGTC_1130 3454-2858 15.9 µM -0.164720632014962 0.469976332137091 no 1808 0.434581938404722 2811 715628 YIL048W NEO1
SGTC_1365 1672-3266 55.4 µM -0.165060463358893 0.469861167056757 no 1809 0.43444819588418 2790 6415873
SGTC_1992 st073643 23.3 µM -0.165086064876452 0.469852491087879 no 1810 0.43443812056785 2686 3161292
SGTC_742 0kpi-0133 140 µM -0.166403413900308 0.469406080745352 no 1811 0.433919743753773 2863 2728852
SGTC_125 0133-0007 11.75 µM -0.168087757462781 0.468835362978104 no 1812 0.43325712022524 2810 26541
SGTC_1725 st036284 20.55 µM -0.168396836304966 0.468730642577095 no 1813 0.433135548414297 2950 707914
SGTC_2059 5238311 157 µM -0.169572259762536 0.468332411856492 no 1814 0.432673270029916 2710 703021
SGTC_1214 0358-0031 63.7 µM -0.171131152451719 0.467804311599837 no 1815 0.43206032053031 3008 4301366
SGTC_2444 5485484 36.41 µM -0.172356075743466 0.46738938861312 no 1816 0.431578800912432 2825 6790631
SGTC_1777 st045864 34.765 µM -0.173028002610911 0.467161799255571 no 1817 0.431314708342665 2713 4691462
SGTC_468 gf-109203x 121 µM -0.174236474943961 0.466752502843863 no 1818 0.430839810536078 2810 2396 A protein kinase C inhibitor.
SGTC_1706 st031321 9.9705 µM -0.175381196580276 0.466364830514064 no 1819 0.430390057275133 2821 6103185
SGTC_3253 9135987 49.47 µM -0.176131529807449 0.466110739363484 no 1820 0.430095305457758 2849 4182430
SGTC_2935 9038016 29.96 µM -0.176310666922954 0.466050078813685 no 1821 0.430024941156598 2797 6463195
SGTC_1172 0370-0043 85 µM -0.17643987579616 0.466006325772494 no 1822 0.429974189837229 2869 376585
SGTC_1407 3909-7909 12.3 µM -0.176485298801629 0.465990944615057 no 1823 0.429956348632591 2719 4411780
SGTC_1062 mesoridazine 14.2 µM -0.177466320977404 0.465658762903144 no 1824 0.429571058641684 2701 4078 A neuroleptic.
SGTC_1741 st038134 10.228 µM -0.177870568752512 0.465521888421157 no 1825 0.429412312486726 2904 1272587
SGTC_2253 7938677 135.83 µM -0.178877335287453 0.465181024535444 no 1826 0.429017009780533 2931 2301972
SGTC_2743 auranofin 4.32 µM -0.179580868197603 0.464942842492458 no 1827 0.428740812728548 2757 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1663 st014140 55.4 µM -0.180688223368379 0.464567971338931 no 1828 0.428306151513302 2729 4207120
SGTC_505 gw-5074 63.9 µM -0.181117669149419 0.464422600198451 no 1829 0.428137607989583 2837 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_774 k060-0086 136 µM -0.182881223826448 0.463825671571426 no 1830 0.427445607823052 2707 5911235
SGTC_1510 1123-0200 71.5 µM -0.183680780855257 0.463555063964341 no 1831 0.427131943512781 2938 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2174 5790901 200 µM -0.185259937979778 0.463020652768601 no 1832 0.426512579461516 2816 786020
SGTC_672 1441-0018 53.7 µM -0.185460788327784 0.462952686667775 no 1833 0.426433816541612 2720 251141
SGTC_2282 7944268 200 µM -0.185462376133878 0.462952149371597 no 1834 0.426433193899438 2892 2970414
SGTC_2240 6690706 185.951 µM -0.185557835798209 0.462919846991786 no 1835 0.42639576069005 2692 805876
SGTC_1452 4194-0072 190 µM -0.186341879237908 0.462654545576891 no 1836 0.426088333833552 2906 1343545
SGTC_618 k072-0232 33.2 µM -0.186849027499854 0.46248294766095 no 1837 0.425889502694792 2832 5872756 YGL099W LSG1
SGTC_392 N-ethylmaleimide 8.33 µM -0.187121146740637 0.462390876684009 no 1838 0.425782824144716 2787 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1169 aniline yellow 25.8 µM -0.187807831419141 0.462158547326238 no 1839 0.425513648213798 2782 6051 A DNA damaging agent.
SGTC_945 3381-0768 11.3 µM -0.187946714687011 0.462111559843722 no 1840 0.425459211091737 2837 1126236 YIL048W NEO1
SGTC_3299 9121982 43.1275 µM -0.188617779744854 0.461884530181728 no 1841 0.425196198361432 2770 17594604 YPL160W CDC60
SGTC_2363 9053361 176 µM -0.188991980717419 0.461757938723411 no 1842 0.425049550995648 2888 6469797 YMR079W SEC14
SGTC_3076 9116187 49.47 µM -0.189683766404689 0.461523919187355 no 1843 0.424778471196439 2853 27241210
SGTC_2046 4110841 106 µM -0.189952643512142 0.461432966146304 no 1844 0.424673119903389 2848 44119630 YMR134W ERG29
SGTC_555 4296-0685 37 µM -0.190525020971706 0.461239354784976 no 1845 0.424448869182617 2717 2908540 YHR072W ERG7
SGTC_484 loperamide 105 µM -0.192766272086661 0.460481322087172 no 1846 0.423571009504759 2705 3955 An opioid-receptor agonist.
SGTC_276 colchicine 750 µM -0.192844869101296 0.460454741709071 no 1847 0.423540231257289 2856 2833 A microtubule depolymerizer.
SGTC_3209 9113616 49.47 µM -0.192875072133709 0.460444527525598 no 1848 0.423528404005848 2904 16649353
SGTC_202 3594-0513 34.79 µM -0.19498066838755 0.459732513194969 no 1849 0.422704040779407 2727 708429
SGTC_232 clozapine 119 µM -0.196632335707255 0.459174086685601 no 1850 0.422057632175356 2735 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_229 benomyl 22.8748 µM -0.196959477717922 0.459063489931476 no 1851 0.421929624335865 2826 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_968 1309-0633 340 µM -0.198883255199637 0.45841318370952 no 1852 0.421177034136637 2858 3761976
SGTC_1956 st077085 54 µM -0.199439895569608 0.458225039857198 no 1853 0.420959327562943 2803 24208685
SGTC_3127 9126946 49.47 µM -0.19989541796051 0.458071080735635 no 1854 0.420781187030988 2856 27243249
SGTC_1285 0929-0069 65.5 µM -0.200619840157141 0.457826250841679 no 1855 0.420497921634844 2799 1206237
SGTC_764 1951-2361 146 µM -0.200688013893958 0.45780321127568 no 1856 0.420471266285205 2775 5438930
SGTC_1287 0971-0001 34.6 µM -0.201229972050424 0.457620059566642 no 1857 0.420259378251344 2762 4665869
SGTC_2293 7624732 200 µM -0.203329940431629 0.45691047241402 no 1858 0.419438577600586 2735 894453
SGTC_1029 k015-0030 64.7 µM -0.204790142582387 0.456417145488874 no 1859 0.418868044438384 2881 2208316
SGTC_780 0109-0199 192 µM -0.205811723247365 0.456072046010583 no 1860 0.41846899170703 2957 610414
SGTC_441 propafenone 146 µM -0.206292492138889 0.455909649244792 no 1861 0.418281221408088 2745 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2236 dapsone 200 µM -0.208909443683444 0.455025810792921 no 1862 0.41725946591405 2800 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1664 st014217 9.02 µM -0.208999920167937 0.45499525759277 no 1863 0.417224150468684 2795 3982782
SGTC_2373 9071805 200 µM -0.209030999838545 0.454984762292863 no 1864 0.417212019377666 2874 10149009
SGTC_3305 9127027 53.8275 µM -0.210847057999803 0.454371552066837 no 1865 0.41650330845123 2821 41905295
SGTC_2593 nobiletin 86.24 µM -0.211504663680535 0.454149531661828 no 1866 0.416246746718319 2858 72344 An anti-infammatory.
SGTC_2468 5987765 72.9 µM -0.211859575362728 0.454029712556916 no 1867 0.416108294429961 2831 26772094
SGTC_113 0099-0221 2.5 µM -0.212253215045745 0.453896823672218 no 1868 0.415954746389687 2938 89219
SGTC_2467 5474540 200 µM -0.21248378254953 0.453818988747038 no 1869 0.41586481428865 2770 5413519
SGTC_2079 5212404 121 µM -0.212705295044169 0.453744212280312 no 1870 0.415778418213958 2888 758462
SGTC_867 0518-0118 155 µM -0.212851709817538 0.45369478761875 no 1871 0.415721314587355 2797 6848158
SGTC_3321 9137793 26.8275 µM -0.214603006563326 0.453103665040844 no 1872 0.415038424825889 2779 4904192
SGTC_1971 st069429 63.5 µM -0.214766690038464 0.453048421556281 no 1873 0.414974612191178 2927 1246522 YGL099W LSG1
SGTC_1906 st060206 94.7 µM -0.216005314533892 0.452630412960325 no 1874 0.414491802478769 2934 5133468
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.216047331327256 0.452616234132208 no 1875 0.414475426801165 2744 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2805 7950783 58.44 µM -0.216143570674187 0.452583757794041 no 1876 0.414437918917939 2909 1178958 YDL195W SEC31
SGTC_1988 st071872 53.4 µM -0.216361722848412 0.452510142677712 no 1877 0.41435290017584 2885 16414116
SGTC_2999 9069765 71.4286 µM -0.216498816615548 0.452463881431536 no 1878 0.414299473746308 2866 2097066
SGTC_1525 8-methoxypsoralen 92.5 µM -0.217310093055616 0.45219013561307 no 1879 0.413983345956917 3059 4114 Related to psoralen; DNA damaging agent.
SGTC_2759 disulfiram 3.38 µM -0.217832349170339 0.4520139248023 no 1880 0.413779869369925 2777 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1478 0453-0656 35.7 µM -0.218072400393969 0.451932933953914 no 1881 0.413686350598688 2814 5258496
SGTC_1004 4084-0029 199 µM -0.218234643371649 0.451878195951296 no 1882 0.413623147011428 2945 716894 YLR208W SEC13
SGTC_3034 9090421 49.47 µM -0.220311193671213 0.451177684577208 no 1883 0.4128144015165 2774 17173761
SGTC_2757 clomiphene 4.22 µM -0.221096822886054 0.450912696950003 no 1884 0.412508522009333 3005 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2343 7990716 14.84 µM -0.221273543873389 0.450853093119458 no 1885 0.412439724181724 2797 6456862
SGTC_299 1273-0059 1.44 µM -0.224292116918411 0.449835171697951 no 1886 0.411265004877194 2901 2848077
SGTC_807 1315-0151 48 µM -0.224928006609551 0.44962077920578 no 1887 0.41101764068387 3027 4011080
SGTC_2788 5282734 71.43 µM -0.225873469933226 0.449302040056367 no 1888 0.410649916270106 2967 743706
SGTC_1090 efavirenz 20.7 µM -0.226328944144007 0.449148500059214 no 1889 0.410472794107559 2854 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_270 tamoxifen 5.46 µM -0.227704731070047 0.44868476970043 no 1890 0.409937897096347 3005 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_928 2764-0428 58.7 µM -0.230403172481634 0.447775422259352 no 1891 0.40888924809086 2930 662578
SGTC_2006 4011487 200 µM -0.231379405080154 0.447446509098959 no 1892 0.408510031731296 2958 45595294
SGTC_2835 9006588 71.43 µM -0.232367152752133 0.447113753049185 no 1893 0.408126429525982 3055 2345538
SGTC_1977 st070720 65.3 µM -0.233193927500097 0.446835254757401 no 1894 0.407805410518288 2932 682188
SGTC_3198 9112019 49.47 µM -0.233285941854388 0.446804261427945 no 1895 0.40776968712949 2805 45595555
SGTC_1493 4348-0038 111 µM -0.23330441267618 0.446798039913194 no 1896 0.40776251616306 2855 800424
SGTC_2346 9031566 143.75 µM -0.235079620476766 0.446200159165286 no 1897 0.407073468009116 2934 4771086
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.235826963225734 0.445948494518334 no 1898 0.406783472269367 2852 689007
SGTC_2942 9052777 62.25 µM -0.237387979911061 0.445422898822212 no 1899 0.406177906950873 2866 6469503
SGTC_215 1287-0124 461.5 µM -0.237726829546694 0.445308820488546 no 1900 0.406046486575429 2887 5560863
SGTC_1445 4239-0156 97.7 µM -0.238977457331121 0.444887818926617 no 1901 0.405561531399961 3011 4008346
SGTC_810 3825-7150 143 µM -0.239703671511648 0.444643380357184 no 1902 0.40527999423066 3026 22330411 YGL099W LSG1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.239981398181219 0.444549905079193 no 1903 0.40517233869233 2797 5355888
SGTC_3077 9117319 49.47 µM -0.240513214044449 0.444370918868496 no 1904 0.404966210270947 2807 17154678
SGTC_962 1254-0300 21.5 µM -0.240679300893637 0.444315023543601 no 1905 0.404901841472112 2814 7340576
SGTC_2403 6032726 181.2 µM -0.244107466355969 0.443161548263129 no 1906 0.403573795062904 2914 2881040
SGTC_2789 5281112 71.43 µM -0.245389354765274 0.442730354265161 no 1907 0.403077485376489 2884 765948
SGTC_2134 5324836 1.464 µM -0.248096381390893 0.441820004209817 no 1908 0.402029917672085 2879 699272
SGTC_2131 toluylene red 5.2905 µM -0.250474186387294 0.441020621864879 no 1909 0.401110332434052 2888 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1915 st067105 30.6 µM -0.250679683285563 0.440951548124604 no 1910 0.401030884808596 2813 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1124 fisetin 1.16336 µM -0.251180597683894 0.440783183132754 no 1911 0.400837242301117 2903 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1292 0kpi-0043 232 µM -0.2513526275499 0.440725363730876 no 1912 0.40077074495016 2899 3333905
SGTC_1283 0922-0125 16.4 µM -0.251700701430927 0.440608379634054 no 1913 0.400636207393782 2970 3360884
SGTC_2229 7354935 190 µM -0.253436705934642 0.440025003740123 no 1914 0.399965383020648 2933 318112
SGTC_407 eburnamonine 100 µM -0.254134833266213 0.439790438068054 no 1915 0.399695696742958 2828 3195
SGTC_3191 9110352 49.47 µM -0.255100792615513 0.439465917666913 no 1916 0.3993226259978 2834 17122424
SGTC_638 3970-0837 4.09 µM -0.256161789560069 0.439109515642609 no 1917 0.398912955979064 2883 4118451 YLR208W SEC13
SGTC_2066 5222451 176 µM -0.25713430456584 0.43878287914532 no 1918 0.398537548207726 2858 2281147
SGTC_2247 cerulenin 830 nM -0.25749227754345 0.438662658025475 no 1919 0.398399388005306 3081 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3245 9134821 49.47 µM -0.259578508271668 0.437962134299398 no 1920 0.39759445805105 2874 17014901
SGTC_2386 9075165 157.42 µM -0.2609641950709 0.437496949583279 no 1921 0.397060059461132 2849 16452277
SGTC_1028 k015-0029 4.8 µM -0.261074058235623 0.437460071440671 no 1922 0.39701769831368 2848 4588309
SGTC_350 k064-0020 19.8 µM -0.262151747122966 0.437098348795093 no 1923 0.39660222645866 3072 2790705
SGTC_2552 juarezic acid 87.02 µM -0.263128610125083 0.436770513437859 no 1924 0.396225726507597 2823 1549512
SGTC_430 0958-0115 16.4 µM -0.264565362650061 0.436288418049759 no 1925 0.395672153068042 2903 6833180
SGTC_2415 st077333 57.7 µM -0.265047736741286 0.436126580931016 no 1926 0.395486343905477 3128 2766255
SGTC_3008 9078912 71.4286 µM -0.265165904288259 0.436086937198898 no 1927 0.395440829714811 2908 16648731
SGTC_2546 rhodinyl acetate 100 µM -0.265427206406487 0.435999275891058 no 1928 0.395340189934302 3018 6708682
SGTC_48 0382-0018 55 µM -0.265972697357934 0.435816285406186 no 1929 0.395130118120958 3145 762596
SGTC_432 NS 1619 61.3 µM -0.267777028781793 0.435211102187405 no 1930 0.394435476788192 3045 4552 A K+/calcium channel activator.
SGTC_534 k292-0788 63.4 µM -0.268155116054891 0.435084308704963 no 1931 0.394289961143649 3037 4146317
SGTC_3000 9075062 71.4286 µM -0.268386556927946 0.435006697128329 no 1932 0.394200893040877 2922 17057871
SGTC_3184 9108758 49.47 µM -0.268468209593589 0.43497931625229 no 1933 0.394169471008888 2823 902885
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.269175268585932 0.434742228723226 no 1934 0.393897405470683 2836 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2162 5663267 200 µM -0.269703294034261 0.434565189137451 no 1935 0.393694263078393 3034 6456493
SGTC_786 4544-0069 423 µM -0.269906361489812 0.434497106936449 no 1936 0.393616146495767 3003 748821 YLR208W SEC13
SGTC_1231 0242-0792 125 µM -0.272080831537784 0.433768196942199 no 1937 0.392779933987475 2862 3707635
SGTC_264 promethazine 12.5 mM -0.273366059233356 0.433337478004246 no 1938 0.392285920143574 2925 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3340 9146634 11.102 µM -0.274914274240876 0.432818729174274 no 1939 0.391691050141854 2967 4907387
SGTC_1203 3992-3522 103 µM -0.276040440953229 0.43244146558353 no 1940 0.391258502538627 3243 5322312
SGTC_1929 genistein trimethyl ether 50.5 µM -0.276847643246131 0.432171092303821 no 1941 0.390948548167383 3090 136420
SGTC_762 1165-0429 115 µM -0.277008817072287 0.432117110756922 no 1942 0.390886667965289 3038 5967793
SGTC_2458 5808907 16.39 µM -0.277499216412363 0.431952870329626 no 1943 0.390698403707654 3060 2731747
SGTC_2417 cerulenin 830 nM -0.278055819152496 0.431766471866239 no 1944 0.390484755013016 2987 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2965 9082772 38.63 µM -0.279671896065578 0.43122535656684 no 1945 0.389864620957294 3082 16459634
SGTC_24 0417-1663 219 µM -0.28077849676608 0.430854904912076 no 1946 0.389440148762339 2991 4329390
SGTC_1600 coumarin 106 71.1 µM -0.280897553535326 0.430815052440673 no 1947 0.389394488567882 3071 100336 A hepatotoxic, DNA x-linker.
SGTC_2690 usnic acid 100 µM -0.281116660369325 0.430741711549311 no 1948 0.389310461548601 3146 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1106 tegaserod maleate 11.7 µM -0.281203917632351 0.430712504884917 no 1949 0.389277000008792 2947 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1408 3909-7976 48.8 µM -0.28152845999226 0.430603877715969 no 1950 0.389152551248995 2945 24152374
SGTC_1269 0831-0796 3.05 µM -0.282308814924496 0.430342707595319 no 1951 0.388853363517207 3038 927758
SGTC_907 3448-6986 75.5 µM -0.282576055387326 0.430253274236294 no 1952 0.388750918784259 3088 590582
SGTC_1928 4'-methoxychalcone 40.3 µM -0.284286743018848 0.429680869001741 no 1953 0.388095322376201 3127 641818
SGTC_1023 4482-3888 16 µM -0.286130186478246 0.429064208425193 no 1954 0.387389206079953 3105 3303168
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.288540956733261 0.428258029603554 no 1955 0.386466342001923 2969 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1477 0139-0234 16 µM -0.289157036636263 0.428052055962921 no 1956 0.38623060394775 2918 620880
SGTC_2015 5119600 184 µM -0.29105698806816 0.427416969968635 no 1957 0.385503867499355 3109 2828786
SGTC_2314 7727897 200 µM -0.292746050368225 0.426852534524793 no 1958 0.384858133979 2920 900724
SGTC_3295 9122362 53.5725 µM -0.293846762593385 0.426484789060458 no 1959 0.384437500122264 3023 4730473
SGTC_1579 chlormadinone acetate 49.4 µM -0.294278183056684 0.426340669873892 no 1960 0.384272671174129 3077 45114258 A steroidal progestin.
SGTC_2585 alliin 100 µM -0.294801591593932 0.426165834599695 no 1961 0.384072725263152 3114 87310 A garlic compound which reacts with lipids.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.294808926008517 0.426163384772503 no 1962 0.384069923681892 2924 165521
SGTC_3136 9095672 49.47 µM -0.295211284722714 0.426028994049354 no 1963 0.38391624099621 2831 17217380
SGTC_509 pifithrin 175 µM -0.297244073792677 0.425350159433535 no 1964 0.383140087778728 3015 4817 A p53 inhibitor.
SGTC_1594 piperine 70.1 µM -0.29867789626361 0.424871478146551 no 1965 0.382592911930662 2918 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_959 1222-0044 107 µM -0.298780729711338 0.424837151473076 no 1966 0.382553677584833 3070 6083612
SGTC_1387 3342-1166 1.8 µM -0.300044598142248 0.42441530814218 no 1967 0.382071568736793 2993 3418228
SGTC_2649 anisomycin 9.56 µM -0.300858013585016 0.42414385895985 no 1968 0.381761384036683 2995 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1010 4112-3296 15.2 µM -0.301028364381231 0.424087014844605 no 1969 0.381696432728631 3098 704384
SGTC_1475 4092-1048 11.7 µM -0.302812302584482 0.423491830123932 no 1970 0.381016453619724 3008 2881759
SGTC_2466 5983409 37.09 µM -0.304383426168451 0.422967792355195 no 1971 0.380417896569326 2963 2879657
SGTC_176 1486-1328 72.834 µM -0.306023341095925 0.422420955054397 no 1972 0.379793437080012 3008 22310231
SGTC_2966 9084041 48.03 µM -0.306190045762215 0.422365374957095 no 1973 0.379729975505726 2853 17741380
SGTC_1480 1070-0044 41.2 µM -0.307371387089008 0.421971554715537 no 1974 0.379280352260328 3019 3124987
SGTC_1245 0418-0076 17.2 µM -0.307685875348486 0.421866727832861 no 1975 0.37916068425597 3119 6790114
SGTC_2427 5545055 42.75 µM -0.307759092684026 0.421842323439202 no 1976 0.37913282550541 2960 5372858
SGTC_981 1488-1094 54.9 µM -0.309264587950242 0.421340586827059 no 1977 0.378560133072028 2900 3449522
SGTC_2348 9022543 33.42 µM -0.310709400945737 0.420859193870168 no 1978 0.378010774921836 3085 3162678 YDL140C RPO21
SGTC_3318 9139014 38.6185 µM -0.310940044560619 0.420782357340496 no 1979 0.377923100588944 2944 16643984
SGTC_2725 haloperidol 53.21 µM -0.313082715797001 0.420068693240804 no 1980 0.377108910132708 2944 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2735 sertaconazole 140 nM -0.32159958763553 0.417234580442057 no 1981 0.373878028136426 3000 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_705 1124-0212 310 µM -0.323388798260654 0.416639735615937 no 1982 0.373200405936722 3121 9554485
SGTC_2341 7987486 176.74 µM -0.323883056393727 0.416475447071492 no 1983 0.373013286096526 3136 1258686
SGTC_2891 9063876 19.48 µM -0.323961324823874 0.416449432435421 no 1984 0.372983657410798 3071 6472478
SGTC_2065 5221596 34.26 µM -0.324715796639506 0.416198682042715 no 1985 0.372698089000237 3110 788581
SGTC_702 1488-0190 94 µM -0.325813172871974 0.415834027505636 no 1986 0.372282855797896 3066 949357
SGTC_3265 9137266 49.47 µM -0.326236161499071 0.415693489096481 no 1987 0.372122841894015 3057 17224265
SGTC_685 1278-0033 54.9 µM -0.327720133090771 0.415200523383883 no 1988 0.371561639670143 3134 3590572
SGTC_1148 3909-7663 27.7 µM -0.327761881247971 0.41518665684418 no 1989 0.371545855466125 3109 4084526
SGTC_2324 6149169 200 µM -0.329646004013067 0.41456096069326 no 1990 0.37083372879187 3043 2888231
SGTC_137 0438-0332 85.389 µM -0.330117136607879 0.414404536624996 no 1991 0.37065572762506 3072 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1734 st037168 69.4 µM -0.33024942437815 0.414360617265699 no 1992 0.370605752239557 3072 708907
SGTC_1177 0983-0204 23.6 µM -0.330752183929356 0.414193711552664 no 1993 0.370415840754966 3137 766818
SGTC_730 1436-0052 41.2 µM -0.33114491110328 0.414063345078012 no 1994 0.370267514666964 2973 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1893 st059353 36.1 µM -0.333942574408716 0.413134930636575 no 1995 0.369211446176783 3058 3112488
SGTC_1463 k081-0032 34.1 µM -0.335376885961299 0.412659137241291 no 1996 0.368670400837405 3060 977755
SGTC_1241 0364-0022 50.8 µM -0.336451680983787 0.412302687615101 no 1997 0.368265141392464 3029 4563895
SGTC_3325 9138760 55.175 µM -0.337679904250348 0.411895442952931 no 1998 0.367802210102093 3018 43844959
SGTC_2969 9091408 28.7 µM -0.338874328068717 0.411499496234076 no 1999 0.36735220231007 2964 4286311
SGTC_2780 5215298 71.43 µM -0.339129507176962 0.411414917049163 no 2000 0.367256085329408 3142 2834131
SGTC_569 4130-2812 160 µM -0.339392971381882 0.411327596086107 no 2001 0.367156856371703 3019 743552
SGTC_3159 9100096 49.47 µM -0.339496008018646 0.411293447448653 no 2002 0.367118051926493 2910 25236875
SGTC_1861 st057647 17.4 µM -0.339591837563353 0.411261688005307 no 2003 0.367081962949726 3185 688668
SGTC_2432 5630864 12.22 µM -0.339629139388504 0.411249325741258 no 2004 0.367067915567192 3144 5714970
SGTC_2709 st078560 56 µM -0.341298754987519 0.410696085899483 no 2005 0.366439342540617 3178 17250903
SGTC_2893 9048488 25.97 µM -0.342874338566897 0.410174167157642 no 2006 0.365846498844928 3041 6467338
SGTC_739 1486-1183 203 µM -0.343201167774359 0.410065923487138 no 2007 0.365723563109096 3143 4346692
SGTC_843 0310-0051 143 µM -0.344534360322601 0.409624450008962 no 2008 0.365222230064973 3048 2065037
SGTC_2048 5246248 200 µM -0.345065012174539 0.409448761759659 no 2009 0.365022748025458 3138 677046
SGTC_2461 5755302 26.15 µM -0.345676171899859 0.409246441491543 no 2010 0.364793046816839 3152 2788904
SGTC_2123 5259487 200 µM -0.346328767396224 0.409030430879991 no 2011 0.364547825759218 3134 2173474
SGTC_191 3914-0123 66.505 µM -0.347458883568581 0.408656425199735 no 2012 0.364123301364636 2984 3144412
SGTC_2287 7945887 168.79 µM -0.347748144525201 0.408560709245108 no 2013 0.364014668214911 3103 1245853
SGTC_1411 3909-8223 150 µM -0.35127330333319 0.407394680137978 no 2014 0.362691660619251 3128 X1411
SGTC_790 1575-0012 79.1 µM -0.353484040491593 0.40666384461015 no 2015 0.361862795682333 3170 378741 YLR208W SEC13
SGTC_1781 st038725 66.3 µM -0.35385154487234 0.406542384775664 no 2016 0.361725071053679 3023 4270275 YIL048W NEO1
SGTC_583 1488-1091 88.9 µM -0.355672134014002 0.405940814676327 no 2017 0.361043058000917 3128 4303273
SGTC_1931 st074438 57.1 µM -0.356366373029297 0.40571147840989 no 2018 0.360783104467225 3048 2787313
SGTC_2884 9058502 51.95 µM -0.357517843189893 0.405331170898221 no 2019 0.360352085373661 3135 6471554
SGTC_2560 caryophyllene 100 µM -0.357984516591963 0.405177063456827 no 2020 0.360177450359016 3009 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1626 st003712 1.76 µM -0.359478583991871 0.404683783343392 no 2021 0.359618548047796 3183 24207035
SGTC_2807 7945238 51.95 µM -0.360295420453352 0.40441416124357 no 2022 0.359313111816685 3112 17148797
SGTC_277 nystatin 15.5 µM -0.361531724490247 0.404006167291199 no 2023 0.358850996852516 2991 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_79 0052-0007 94.094 µM -0.361923847978564 0.40387678400748 no 2024 0.358704469110334 3192 2801472
SGTC_2588 indole-3-carbinol 100 µM -0.362091343115566 0.403821521278004 no 2025 0.35864188627565 3165 3712 Induces cell cycle arrest.
SGTC_2429 5902844 64.44 µM -0.362337961754879 0.403740156325816 no 2026 0.358549746667156 3170 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2794 7785382 27.27 µM -0.36246790976407 0.403697285274416 no 2027 0.35850119988258 3145 2205081
SGTC_2924 9010168 62.78 µM -0.363050146966822 0.403505214042685 no 2028 0.358283712175934 3134 2993929
SGTC_895 0964-0006 13.7 µM -0.364618682603816 0.402987893816806 no 2029 0.357698033452934 3176 6738897
SGTC_2339 9000433 200 µM -0.365331538948649 0.40275284204431 no 2030 0.357431969167828 3082 2988954
SGTC_3137 9097352 49.47 µM -0.368097843204769 0.40184103568849 no 2031 0.356400139519187 3345 44120435
SGTC_358 0075-0058 9.45 µM -0.368665150612592 0.401654110335691 no 2032 0.356188663773595 3258 1069125
SGTC_1901 st060216 58.6 µM -0.369821228076076 0.401273257464698 no 2033 0.35575784858164 3027 688792
SGTC_2601 securinine 100 µM -0.370022586113328 0.401206932573678 no 2034 0.355682830816052 3034 442872 A GABA receptor antagonist.
SGTC_250 brefeldin a 552.239 µM -0.370527341723307 0.401040684724767 no 2035 0.355494804100885 3034 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3121 9125696 49.47 µM -0.372278472012691 0.400464066194127 no 2036 0.354842762715056 3098 1235365
SGTC_2097 5376186 200 µM -0.372726849547852 0.400316457636782 no 2037 0.354675875548719 3170 742755
SGTC_2428 5615643 7.78 µM -0.37283522954948 0.400280780430044 no 2038 0.354635540442984 3157 2253075
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.377139562311496 0.398864528997418 no 2039 0.353034945876471 3287 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.377165994042811 0.398855836275784 no 2040 0.353025125056786 3313 6728940
SGTC_3030 9087619 49.47 µM -0.377379024840176 0.398785777717103 no 2041 0.352945976153047 3111 25236973
SGTC_136 0097-0015 404.482 µM -0.37744342597346 0.398764599024153 no 2042 0.352922049977264 3161 4861337
SGTC_1191 1487-1166 10.6 µM -0.378254274439623 0.398497972241076 no 2043 0.352620855019579 3179 3955771
SGTC_626 0214-0009 33 µM -0.378442508757646 0.398436082969835 no 2044 0.352550947356525 3208 3437874
SGTC_3171 9103192 49.47 µM -0.379473538629712 0.398097137601213 no 2045 0.352168125293251 3185 13018434
SGTC_3246 9135460 32.98 µM -0.380047412682466 0.397908512969618 no 2046 0.351955110333339 3151 41446951
SGTC_1157 4092-0394 27.6 µM -0.380182546929553 0.397864099641394 no 2047 0.35190495692503 3261 3659885
SGTC_1270 0831-1170 17.3 µM -0.381266714382916 0.397507824264858 no 2048 0.351502674878832 3100 6764716
SGTC_3020 9089140 49.47 µM -0.381820626137163 0.397325832665268 no 2049 0.351297209190054 3177 17217859
SGTC_1728 st035614 33.7865 µM -0.384189273595757 0.396547849497577 no 2050 0.350419083928698 3116 15945546
SGTC_83 0170-0301 39.027 µM -0.384824788919231 0.396339184162879 no 2051 0.350183615974943 3121 3089716
SGTC_3085 9117376 49.47 µM -0.384935338247932 0.396302889385626 no 2052 0.350142661668443 3177 16480349
SGTC_1998 st075797 76.8 µM -0.385041587693397 0.396268007162709 no 2053 0.350103301946932 3200 24208315
SGTC_1302 1159-0335 255 µM -0.385109869894965 0.396245590213651 no 2054 0.350078007903038 3074 649284
SGTC_2597 laccaic acid a 100 µM -0.386186465977017 0.395892190650026 no 2055 0.349679288173473 3191 5491415 A textile dye.
SGTC_2211 7117706 200 µM -0.387373172067537 0.395502745909057 no 2056 0.349239981009008 3171 822771
SGTC_1799 st045822 46.1415 µM -0.387585542694549 0.395433062625645 no 2057 0.349161384732323 3219 3674992
SGTC_126 0417-1624 672.48 µM -0.387956500470755 0.395311351573757 no 2058 0.34902411243503 3216 41912 YDL195W SEC31
SGTC_2903 5923464 63.88 µM -0.388090698236328 0.395267323871881 no 2059 0.348974457643909 3180 2876576
SGTC_1803 st050068 52.4 µM -0.388290884350095 0.395201649148872 no 2060 0.348900391174682 3184 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3070 9117005 49.47 µM -0.388786008269843 0.395039227463655 no 2061 0.348717225976094 3171 8779016
SGTC_1788 fluconazole 20 µM -0.390312507922066 0.394538585612194 no 2062 0.34815273767639 3184 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3051 9093778 49.47 µM -0.390796144535632 0.39438000494179 no 2063 0.347973962513339 3151 17217378
SGTC_595 3909-8003 73.7 µM -0.392063646580572 0.393964484028795 no 2064 0.34750559368636 3204 699517
SGTC_412 gemfibrozil 100 µM -0.393892846437513 0.393365036477099 no 2065 0.346830076019122 3160 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1389 3405-0187 19 µM -0.394577635236198 0.393140689096091 no 2066 0.34657731076584 3135 799890
SGTC_2493 resveratrol 26.09 µM -0.394841558316113 0.393054233290398 no 2067 0.34647991124139 3040 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_486 niguldipine 82 µM -0.39610413286789 0.392640712722321 no 2068 0.346014104777052 3100 1236 A calcium channel blocker.
SGTC_2409 alverine citrate 63.97 µM -0.396873599573731 0.392388755067173 no 2069 0.345730336658534 3317 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3021 9087658 49.47 µM -0.397316935866965 0.392243607499984 no 2070 0.345566880020712 3242 25237042
SGTC_2971 9092186 9.93 µM -0.398108586011381 0.391984459852092 no 2071 0.345275072828923 3049 25236400
SGTC_1747 st037496 66.6 µM -0.398180013913432 0.391961080195254 no 2072 0.345248748577995 3098 723305
SGTC_1341 1486-1360 280 µM -0.400083879507082 0.391338054240134 no 2073 0.344547368590078 3099 3976547
SGTC_1117 retinoic acid 1.10837 µM -0.400345611265904 0.391252426208483 no 2074 0.344450988880183 3254 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1917 st066507 28.5 µM -0.401668271431311 0.390819786063551 no 2075 0.343964089063555 3074 3156428
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.40170628661107 0.390807353350469 no 2076 0.343950098673364 3069 15053
SGTC_417 st075190 100 µM -0.40356289775737 0.390200292144154 no 2077 0.343267086843682 3247 222757
SGTC_2786 7743617 45.45 µM -0.404902284193379 0.389762515407057 no 2078 0.342774669648451 3127 583674
SGTC_866 0495-0101 262 µM -0.405049231769397 0.38971449428184 no 2079 0.342720661513567 3104 635694
SGTC_821 1114-0266 29.2 µM -0.405895683410639 0.389437914419957 no 2080 0.342409624923885 3200 3123235
SGTC_2739 tacrine 100.86 µM -0.406516340975297 0.389235148822925 no 2081 0.342181626367932 3223 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.407374650507585 0.388954793264141 no 2082 0.341866421148297 3062 107982 A Capsaicinoid.
SGTC_319 1348-1596 45.5 µM -0.407392537729281 0.38894895125209 no 2083 0.341859853424249 3287 5380505
SGTC_1500 4488-1866 171 µM -0.408238860665411 0.388672568752111 no 2084 0.341549160318226 3252 2900003
SGTC_53 0973-0023 39.979 µM -0.408639886637041 0.388541625926274 no 2085 0.341401977379733 3294 674768
SGTC_3079 9117512 49.47 µM -0.408852110040139 0.388472335956547 no 2086 0.34132409775767 3178 7185044
SGTC_490 phenamil 164 µM -0.409396415750709 0.388294638861719 no 2087 0.341124384788367 3167 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1934 st074720 32.6 µM -0.409545120406838 0.388246095970438 no 2088 0.341069830818946 3075 17250992
SGTC_2802 7925815 54.55 µM -0.409620312394225 0.388221551092354 no 2089 0.341042247060418 3106 1262923
SGTC_1237 0330-0133 46.1 µM -0.411401386012693 0.387640286970372 no 2090 0.340389118885579 3086 X1237 YHR072W ERG7
SGTC_957 1187-1561 14.1 µM -0.412464825837595 0.387293346904558 no 2091 0.339999378423127 3232 1538454
SGTC_2658 polymyxin b sulfate 77.05 µM -0.41263712661906 0.387237143402801 no 2092 0.339936247924499 3157 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_321 4534-3890 65.3 µM -0.412816706963408 0.387178567866055 no 2093 0.339870454992221 3222 699746
SGTC_2362 9071156 126 µM -0.415404903774277 0.386334635483645 no 2094 0.338922758726424 3267 653133
SGTC_2074 5212007 75.395 µM -0.415575818327353 0.386278924311687 no 2095 0.338860212301003 3236 758611
SGTC_301 4119-0100 24.5 µM -0.417136057458923 0.385770458526753 no 2096 0.338289446124582 3161 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2238 6671620 73.2395 µM -0.417621606468647 0.385612263119949 no 2097 0.338111898453285 3072 729941
SGTC_2678 equilin 100 µM -0.418167188669307 0.385434531162727 no 2098 0.337912441772193 3244 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_678 1218-2179 85.9 µM -0.418681654030801 0.385266958040591 no 2099 0.3377244026218 3208 6820081 YOR116C RPO31
SGTC_3061 glucosamine 200 µM -0.419924487347353 0.384862227268008 no 2100 0.337270309238936 3256 91431 and experimental redox chemotherapeutic
SGTC_1552 6-methylflavone 10.6 µM -0.420255936594214 0.384754311427137 no 2101 0.337149247789125 3248 689013
SGTC_1708 st033234 31.827 µM -0.422155332551317 0.384136063639418 no 2102 0.336455821152423 3265 674664
SGTC_1066 ketoconazole 628 nM -0.422257498217101 0.384102817354372 no 2103 0.336418538504774 3275 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_156 3474-0145 5.642 µM -0.424146016214819 0.383488418257396 no 2104 0.335729663972368 3268 2265471
SGTC_1503 4585-0012 61.3 µM -0.424431220769747 0.383395656937476 no 2105 0.335625677823373 3297 2922052
SGTC_2636 apigenin dimethyl ether 100 µM -0.424886886881776 0.38324746774159 no 2106 0.335459567173041 3291 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_460 trequinsin 123 µM -0.426484105438601 0.382728164224296 no 2107 0.334877563765609 3243 5537 A vasodilator.
SGTC_3064 1327-0027 10 µM -0.426574871336441 0.382698659836817 no 2108 0.334844501870803 3151 16000455 YPR107C YTH1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.426578072739991 0.382697619200135 no 2109 0.334843335768239 3282 5377381
SGTC_2708 st078559 56 µM -0.42666056447636 0.382670805026153 no 2110 0.334813288926112 3252 17250902
SGTC_2334 9017922 200 µM -0.428113299231517 0.382198681729113 no 2111 0.33428431735094 3255 3163164
SGTC_139 0099-0334 718.624 µM -0.428673560595345 0.382016649509054 no 2112 0.334080402117184 3166 97690
SGTC_1863 st057641 20.1 µM -0.431290747100347 0.381166656247807 no 2113 0.333128488707391 3234 3921635
SGTC_1496 4469-0713 57.4 µM -0.432104382894726 0.380902525328134 no 2114 0.332832774672395 3264 746691
SGTC_1745 st081495 74 µM -0.433225307124745 0.380538730139986 no 2115 0.332425547652019 3237 13842402 YBL026W LSM2
SGTC_3300 9124615 50.48 µM -0.433468754033397 0.38045973356251 no 2116 0.332337130540087 3330 24824903
SGTC_1798 st045719 60.953 µM -0.433501070018306 0.380449247658212 no 2117 0.332325394448099 3252 3980186
SGTC_302 1094-0063 18.9 µM -0.434709485396488 0.38005720365145 no 2118 0.331886656240632 3158 5440289
SGTC_2103 5378138 10 µM -0.434913184313611 0.379991130106208 no 2119 0.331812722150375 3278 244142
SGTC_3243 9134147 49.47 µM -0.436133868858456 0.379595251744964 no 2120 0.331369802610458 3260 24282180
SGTC_2517 totarol 10 µM -0.437673824286712 0.379096011166248 no 2121 0.330811373515875 3249 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_397 arbidol 50 µM -0.437927601280794 0.379013758129098 no 2122 0.330719383261762 3306 131410 A RNA synthesis inhibitor.
SGTC_1152 3909-8331 15.9 µM -0.439456868135535 0.378518215250488 no 2123 0.330165264148601 3195 16001939
SGTC_2645 abamectin 100 µM -0.441046762380871 0.378003238429689 no 2124 0.32958957183966 3252 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1625 st003711 30.1 µM -0.441245725170643 0.377938808358777 no 2125 0.329517556850333 3374 24207034 YER133W GLC7
SGTC_2964 9083345 53.42 µM -0.442085442793069 0.377666920230852 no 2126 0.329213689010147 3210 17741579
SGTC_1973 st070275 50.2 µM -0.442293495946473 0.377599565064104 no 2127 0.329138418434694 3248 17118334
SGTC_1367 1812-0510 76.9 µM -0.443473919610162 0.377217485009006 no 2128 0.328711489691788 3223 1142582 YDR527W RBA50
SGTC_3007 9078383 71.4286 µM -0.443802766440015 0.3771110651069 no 2129 0.328592594061356 3186 6496995
SGTC_3252 9135871 49.47 µM -0.444101807044763 0.377014299061053 no 2130 0.328484490030372 3314 17682838
SGTC_2867 9039098 71.43 µM -0.445735933528942 0.376485651395477 no 2131 0.327894002418063 3158 6463460
SGTC_3149 9097855 49.47 µM -0.446285082681419 0.376308050978941 no 2132 0.327695665169972 3308 25236625 YMR079W SEC14
SGTC_701 4424-0219 185 µM -0.44696001550816 0.37608980671676 no 2133 0.327451964972509 3348 2911779
SGTC_3192 9110362 49.47 µM -0.44781931875654 0.37581200232714 no 2134 0.327141799924219 3284 16649480
SGTC_2770 toltrazuril 17.5 µM -0.44848545837077 0.375596690138657 no 2135 0.326901439287165 3308 68591 Kills coccidiodes.
SGTC_936 3005-4620 401 µM -0.448972606617301 0.375439256742287 no 2136 0.326725708875111 3376 777207
SGTC_2451 5856223 45.7 µM -0.449560724033827 0.375249220424633 no 2137 0.326513606766536 3201 2179896
SGTC_132 0417-1715 25.805 µM -0.449635012393548 0.375225218040151 no 2138 0.326486818964967 3354 6769098
SGTC_1612 st002233 45.4 µM -0.450414381776492 0.374973434865644 no 2139 0.326205838417203 3280 1035021
SGTC_2983 9022671 12.99 µM -0.451169826484844 0.37472943164328 no 2140 0.325933577385684 3356 6405161
SGTC_1495 4469-0029 237 µM -0.451223828609154 0.374711991263698 no 2141 0.32591411866054 3233 793680
SGTC_2453 5731132 22.18 µM -0.451850250776781 0.374509702395591 no 2142 0.325688433002455 3321 1362040
SGTC_359 0081-0058 15.9 µM -0.452922224424565 0.374163612897781 no 2143 0.325302373490448 3519 3494159
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.453819136980328 0.373874120225294 no 2144 0.324979504278323 3513 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3167 9103034 49.47 µM -0.454170244155095 0.373760814211192 no 2145 0.324853149027433 3288 5127859
SGTC_2852 9023854 51.95 µM -0.454740426151284 0.373576833672482 no 2146 0.324647996809184 3346 19798528
SGTC_114 0364-0001 490.298 µM -0.455426080057583 0.373355631984298 no 2147 0.324401368086612 3274 4003655
SGTC_1993 st073995 70.8 µM -0.45646848701137 0.373019416659216 no 2148 0.324026563358625 3237 3098394
SGTC_880 0833-0487 87.2 µM -0.456985290449153 0.372852764007775 no 2149 0.323840809150699 3199 76075
SGTC_2005 4024620 188 µM -0.458522830092072 0.372357097238145 no 2150 0.323288432151652 3243 236743
SGTC_1853 st056710 91.2 µM -0.458906006297526 0.372233603074238 no 2151 0.323150832698256 3356 269167
SGTC_1334 1486-0610 236 µM -0.45963558846293 0.371998501792097 no 2152 0.322888904972256 3290 3742339
SGTC_1587 estradiol valerate 56.1 µM -0.461060514237223 0.371539469963007 no 2153 0.32237759488064 3349 13791 A steroid.
SGTC_890 0929-0006 47.2 µM -0.461668528270952 0.371343657206812 no 2154 0.322159521676021 3202 1378169
SGTC_1826 st055655 41.6 µM -0.462447992039692 0.37109267725248 no 2155 0.321880045029034 3277 676168
SGTC_2380 9035439 200 µM -0.462509609119188 0.371072839472858 no 2156 0.321857956526124 3355 6462575
SGTC_2869 9037858 32.47 µM -0.462977115451851 0.370922335752842 no 2157 0.321690385274372 3212 27187042
SGTC_827 3253-0474 693 µM -0.463725650250549 0.370681402018004 no 2158 0.321422158742811 3322 5402065
SGTC_741 4582-0002 126 µM -0.464696067954571 0.370369125477326 no 2159 0.321074562294126 3206 2912688
SGTC_1698 5-fluorocytosine 1.055 µM -0.465489343904702 0.370113915880475 no 2160 0.32079053311471 3326 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_62 0180-0423 3.232 µM -0.467269584082527 0.369541392347911 no 2161 0.320153507397723 3247 30102 YGL099W LSG1
SGTC_857 0438-0306 1.35 µM -0.467671770216518 0.369412089668189 no 2162 0.32000966589097 3317 4686136
SGTC_2220 6782180 200 µM -0.472230810317014 0.3679473960098 no 2163 0.318381025124232 3276 833803
SGTC_1314 1222-0010 41.1 µM -0.474998183067983 0.367059249547944 no 2164 0.317394134164089 3265 3526027
SGTC_2760 etidronate 98.04 µM -0.475806036495159 0.36680011505537 no 2165 0.317106284454331 3222 3305 A chelator and antioxidant.
SGTC_11 0438-0307 1.3 µM -0.476840373159037 0.366468420326654 no 2166 0.316737897043821 3335 4011476
SGTC_198 3454-2873 16.191 µM -0.477910703560136 0.366125287981338 no 2167 0.316356881415503 3262 710957
SGTC_1015 4130-4525 82 µM -0.478258278137493 0.366013883640263 no 2168 0.316233193902833 3235 1363237
SGTC_3181 9108277 49.47 µM -0.478570753749564 0.36591373883442 no 2169 0.316122014219211 3236 17097298
SGTC_2878 9043973 25.97 µM -0.479070600452045 0.36575356276625 no 2170 0.315944201955628 3369 6465167
SGTC_2471 5466956 24.79 µM -0.483065393613649 0.364474272757468 no 2171 0.314524652480234 3216 724419
SGTC_2716 st080858 38.6235 µM -0.483084849128644 0.364468046014586 no 2172 0.314517745646916 3361 5296050
SGTC_1048 3161-0300 24.5 µM -0.483612428236538 0.364299207816343 no 2173 0.314330476414618 3341 2165101
SGTC_3019 9081971 49.47 µM -0.483779692323187 0.364245684719335 no 2174 0.314271114405352 3414 16451803
SGTC_1273 0849-0096 14.1 µM -0.487766353120744 0.362970772551396 no 2175 0.312857673296822 3304 5286025
SGTC_3111 9122088 49.47 µM -0.487885271128622 0.362932766461026 no 2176 0.312815553885917 3245 16876704
SGTC_1485 3909-9022 254 µM -0.488630555651656 0.362694604941394 no 2177 0.312551638218699 3341 714516
SGTC_2726 cimetidine 79.27 µM -0.491581029931464 0.361752279837029 no 2178 0.311507778326705 3295 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1047 2043-3044 82 µM -0.492022320955276 0.361611411793158 no 2179 0.311351782135376 3265 669592
SGTC_573 3702-0553 84.7 µM -0.493337177745591 0.361191797073794 no 2180 0.310887181690206 3303 1222756
SGTC_396 dithiazanine 1.25 µM -0.493510268730728 0.361136570384706 no 2181 0.310826042971323 3264 10578 An antihelmenthic.
SGTC_1288 0973-0013 65.5 µM -0.499274849541126 0.359298973649905 no 2182 0.308792885325246 3388 4315430
SGTC_1326 1431-2094 10.8 µM -0.499560001774144 0.359208158629088 no 2183 0.308692463881224 3215 616278
SGTC_634 1611-4317 11.2 µM -0.500304533785309 0.358971078268329 no 2184 0.308430331103301 3404 2843522
SGTC_2950 9072895 21.46 µM -0.500321405839459 0.358965706351042 no 2185 0.308424391967792 3364 17332245
SGTC_3187 9109394 49.47 µM -0.501486900539979 0.358594690398715 no 2186 0.308014247339035 3288 17098090
SGTC_2118 5526350 200 µM -0.504636721858955 0.357592665265702 no 2187 0.306907006387056 3343 743594
SGTC_1403 3909-7815 62.9 µM -0.504695081828787 0.357574108952164 no 2188 0.306886507966499 3278 6615483
SGTC_3081 9117243 49.47 µM -0.507177090049882 0.356785234222706 no 2189 0.306015284164367 3423 45595589
SGTC_221 trifluoperazine 10.304 µM -0.508655642022196 0.356315585986208 no 2190 0.305496809909937 3375 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1611 st001856 99.4 µM -0.508907633247608 0.356235565033646 no 2191 0.305408484630714 3312 647478
SGTC_525 k781-2675 26.7 µM -0.509484204626221 0.356052496004759 no 2192 0.305206433586345 3401 3651118 YDL195W SEC31
SGTC_868 0527-0199 213 µM -0.510213968796161 0.355820833820599 no 2193 0.304950783455884 3277 2849450
SGTC_776 4476-4378 112 µM -0.510472698897312 0.355738713242421 no 2194 0.304860168276364 3378 2892008
SGTC_2972 9093619 59.92 µM -0.510672221781472 0.355675389525135 no 2195 0.304790297444089 3236 25236256
SGTC_540 1187-0821 17.3 µM -0.513635029277653 0.354735535925838 no 2196 0.303753592017147 3290 847520
SGTC_1404 3909-7820 48.3 µM -0.514018794957969 0.354613863350265 no 2197 0.303619425113661 3394 23741373
SGTC_1615 st002656 86.5 µM -0.522254037723584 0.352006479294265 no 2198 0.300746733112662 3420 1584458
SGTC_1938 st074717 56.4 µM -0.524063903039128 0.351434378989761 no 2199 0.300117047023705 3341 17250979
SGTC_1946 st076057 65.1 µM -0.524226258529821 0.351383074673875 no 2200 0.300060589658722 3323 953009
SGTC_1421 4029-0249 71.4 µM -0.524758851759226 0.3512147942904 no 2201 0.299875419866681 3450 2894095
SGTC_2371 9071574 200 µM -0.525073400093823 0.351115421981278 no 2202 0.299766083316068 3398 45596039
SGTC_1344 1488-0097 29.1 µM -0.526877662365059 0.350545615148379 no 2203 0.299139273411486 3401 747966
SGTC_3356 9151811 4.48 µM -0.530061140775483 0.349541056297416 no 2204 0.298034770204985 3303 1859254 YPR165W RHO1
SGTC_39 0986-0283 58.349 µM -0.530937656409844 0.349264652952858 no 2205 0.297730990987492 3482 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_376 3970-0862 59.1 µM -0.530993339977342 0.349247096210801 no 2206 0.297711697176472 3410 3135186
SGTC_421 streptovitacin 30 mM -0.533103222738722 0.348582099033001 no 2207 0.296981064156838 3456 91467 include heat shock
SGTC_2040 5100729 123 µM -0.533909298799015 0.348328160982469 no 2208 0.296702144132962 3341 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_783 0848-0141 92.7 µM -0.541832494982642 0.345835750765884 no 2209 0.293966951844635 3408 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_602 3130-1533 38.1 µM -0.543597501972682 0.345281434274937 no 2210 0.293359239580505 3456 720941
SGTC_3029 9088683 49.47 µM -0.544151320795107 0.345107570757473 no 2211 0.293168673432476 3439 25236615
SGTC_3046 9092212 49.47 µM -0.544292638726142 0.345063211243067 no 2212 0.293120055868385 3409 25236637
SGTC_2911 7942208 15.64 µM -0.544361048315612 0.345041738326817 no 2213 0.293096522281684 3411 1243384
SGTC_295 k015-0027 31 µM -0.544392254105066 0.345031943384733 no 2214 0.293085787467363 3410 3887424
SGTC_2106 5357045 167.29 µM -0.546515197364123 0.344365833384298 no 2215 0.29235592202911 3397 668842
SGTC_1293 1000-1278 195 µM -0.549552462700018 0.343413678310419 no 2216 0.29131318584092 3486 678847
SGTC_2951 9072950 58.06 µM -0.552485124390337 0.342495257502251 no 2217 0.290308011701843 3474 16488155
SGTC_2035 5154463 94.595 µM -0.55276450350145 0.34240781288687 no 2218 0.290212338900297 3465 2769623
SGTC_3017 9080681 49.47 µM -0.553584584794114 0.342151179318997 no 2219 0.289931589100101 3425 16451914
SGTC_245 methotrexate 289.6 µM -0.553622563418589 0.34213929617711 no 2220 0.289918590437234 3419 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1807 st050092 58.9 µM -0.554629805833808 0.341824196916928 no 2221 0.289573948809445 3367 5008496
SGTC_3052 9092717 49.47 µM -0.555726275007111 0.341481309761192 no 2222 0.289198995857132 3472 25237534
SGTC_203 k066-0004 30.888 µM -0.556081369849845 0.3413702927476 no 2223 0.28907761516171 3498 6795412
SGTC_2581 avocatin a 64 µM -0.556348861960297 0.341286672955646 no 2224 0.288986195194939 3367 6710728 A skin care supplement.
SGTC_3211 9128781 49.47 µM -0.556567892122932 0.341218208489433 no 2225 0.288911348051077 3372 17194361
SGTC_2366 9070441 60.58 µM -0.556682860900468 0.341182273631076 no 2226 0.288872064489404 3378 6837235
SGTC_753 1322-0200 289 µM -0.558405353784948 0.340644060598631 no 2227 0.288283808895043 3495 5403907
SGTC_644 1498-1197 63.3 µM -0.559563886645956 0.340282245799755 no 2228 0.287888471630796 3486 6741615
SGTC_724 3910-0327 137 µM -0.560802200330388 0.339895677626841 no 2229 0.287466193276895 3462 2885483
SGTC_271 rotenone 740 µM -0.56288818176694 0.339244871097185 no 2230 0.286755514121425 3498 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1141 3253-0389 52.6 µM -0.565892904725655 0.338308268621871 no 2231 0.285733292582693 3454 5402031
SGTC_166 k072-0058 166.424 µM -0.566326564549898 0.338173174885933 no 2232 0.285585902638341 3493 5846229
SGTC_65 0798-0905 34.986 µM -0.567045024236783 0.337949406133535 no 2233 0.285341796126489 3643 3602145
SGTC_334 1502-1024 68.5 µM -0.567552985610634 0.337791232937133 no 2234 0.285169269291768 3484 3296216
SGTC_2038 4100038 30.985 µM -0.569208374124671 0.337275963318796 no 2235 0.284607369176744 3458 3596803
SGTC_3088 9117578 49.47 µM -0.5693034641147 0.337246374095502 no 2236 0.284575108178288 3503 678341
SGTC_1578 josamycin 24.2 µM -0.57021857743838 0.336961669081673 no 2237 0.28426472874063 3393 5282165 A P450 substrate.
SGTC_3148 9097893 49.47 µM -0.570816428511846 0.336775719369448 no 2238 0.284062042731596 3355 17174100
SGTC_2677 mitomycin C 100 µM -0.570875602722777 0.336757316574458 no 2239 0.284041984999889 3461 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2321 7390090 138.78 µM -0.572163441608093 0.336356903935476 no 2240 0.283605626153089 3386 649046
SGTC_570 0987-0065 62.6 µM -0.572493497479799 0.336254313385655 no 2241 0.283493844943655 3374 3104428
SGTC_2822 7994718 71.43 µM -0.573668195724313 0.335889283446605 no 2242 0.283096177065377 3443 1018011
SGTC_103 0844-0104 51.839 µM -0.574631497692817 0.335590059008538 no 2243 0.282770272579314 3538 5375804
SGTC_2871 9038510 12.99 µM -0.576760223345718 0.334929196213689 no 2244 0.282050721675075 3528 4945164
SGTC_1465 k213-0056 144 µM -0.577174943553224 0.334800505730959 no 2245 0.281910640824516 3387 24048857 YMR208W ERG12
SGTC_3037 9091026 49.47 µM -0.577801884000179 0.334605998706627 no 2246 0.281698941586866 3511 25236398 YIL048W NEO1
SGTC_3317 9138495 8.753 µM -0.578275267848099 0.334459161712891 no 2247 0.281539144669889 3504 17020139
SGTC_2993 9054257 71.4286 µM -0.579440780341639 0.334097744128709 no 2248 0.281145897124123 3474 6470217 YGL055W OLE1
SGTC_439 amiodarone 34.4 µM -0.586450191427059 0.3319274265086 no 2249 0.278786511910416 3400 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2222 6885208 172.143 µM -0.586749046022386 0.331835017009457 no 2250 0.278686131300542 3475 609514
SGTC_179 1273-0063 6.77 µM -0.588622744518142 0.33125587982303 no 2251 0.278057186448611 3411 3108139
SGTC_1137 ixabepilone 100 µM -0.589173126637442 0.331085840053294 no 2252 0.277872571209885 3524 154225 A novel microtubule stabilizer.
SGTC_3123 9126162 49.47 µM -0.59056876113216 0.330654816978243 no 2253 0.277404700510476 3509 25239884
SGTC_811 0416-0114 265 µM -0.591220043051508 0.330453754035402 no 2254 0.27718649747988 3514 6612453
SGTC_1265 0819-1001 68.8 µM -0.591236890785215 0.330448553473048 no 2255 0.277180853993277 3518 3106768
SGTC_110 0850-0284 111.64 µM -0.591250138666887 0.330444464136853 no 2256 0.277176416388857 3401 3906265
SGTC_3035 9091303 49.47 µM -0.591485446986346 0.330371832892463 no 2257 0.277097601637128 3530 25237002
SGTC_2255 7941087 197.44 µM -0.592727580204852 0.329988536832959 no 2258 0.276681740299643 3553 935561
SGTC_852 0418-0143 439 µM -0.593487829847232 0.329754027846402 no 2259 0.276427362660167 3527 5369229
SGTC_924 2046-0044 21.3 µM -0.593837380387452 0.329646226840505 no 2260 0.276310442421962 3517 3623589
SGTC_508 roscovitine 141 µM -0.595388158090836 0.329168139458201 no 2261 0.275792019657217 3503 160355 A CDKinase inhibitor.
SGTC_1103 duloxetine 36.1 µM -0.596317932909092 0.32888163414908 no 2262 0.275481426635434 3565 60835 A selective serotonin reuptake inhibitor.
SGTC_2143 5623677 140.463 µM -0.596661164265291 0.328775894572743 no 2263 0.275366813054962 3507 5375313
SGTC_1729 st035615 45.989 µM -0.598804463300386 0.328115916889344 no 2264 0.27465164281544 3453 17385451
SGTC_2686 alizarin 95.37 µM -0.602369495017 0.327019339102734 no 2265 0.27346410545367 3455 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3264 9137442 49.47 µM -0.604140891363425 0.326475024654267 no 2266 0.272874987525973 3582 17015726
SGTC_213 1246-0773 967 nM -0.60431649837294 0.326421084254088 no 2267 0.272816619752931 3476 6251622
SGTC_2545 solidagenone 89.61 µM -0.604377792551146 0.326402257656819 no 2268 0.27279624842137 3382 6708572 An anti ulcer agent
SGTC_80 0159-0065 512.242 µM -0.605076900193979 0.326187557010748 no 2269 0.27256395098636 3504 1548079
SGTC_2370 9071495 200 µM -0.605939877012417 0.325922610472001 no 2270 0.27227733907601 3482 21791103
SGTC_712 r015-0009 80.6 µM -0.607655103123198 0.325396271898745 no 2271 0.271708123069832 3508 6813872 YLR060W FRS1
SGTC_1797 st048695 56.8 µM -0.610053251543859 0.324660953724494 no 2272 0.270913266376408 3523 592262 YIL048W NEO1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.611082300596114 0.324345636802746 no 2273 0.270572548313926 3605 688664
SGTC_2181 6316240 54.2555 µM -0.612595807591018 0.323882103122175 no 2274 0.270071815505078 3516 12779990
SGTC_3205 9113483 49.47 µM -0.61498445534057 0.323151100366672 no 2275 0.269282493113263 3534 17018033
SGTC_1684 st024538 14.6195 µM -0.615633616822788 0.322952553961648 no 2276 0.269068179515241 3497 6732859
SGTC_2821 7996764 71.43 µM -0.618523874228759 0.322069180015942 no 2277 0.268115032643314 3639 2987135
SGTC_2138 5575593 77.673 µM -0.619557002373546 0.321753659669435 no 2278 0.267774741205747 3528 762213
SGTC_2379 9035213 200 µM -0.620724552322801 0.321397241177401 no 2279 0.267390436050666 3565 646551
SGTC_2193 5925765 200 µM -0.62433107656274 0.320297315243951 no 2280 0.266205089488789 3561 877370
SGTC_3174 9107204 49.47 µM -0.625254614243949 0.320015905859599 no 2281 0.265901981240523 3594 3938802
SGTC_2146 5545642 200 µM -0.626331051528919 0.319688037387696 no 2282 0.265548911656491 3568 825326
SGTC_1721 st082152 9.2685 µM -0.62654184314244 0.319623849552024 no 2283 0.265479800222574 3542 5296051
SGTC_2195 6536160 144.242 µM -0.628237570144179 0.319107682973938 no 2284 0.264924160940987 3441 3834386
SGTC_2445 5742597 35.57 µM -0.628661543277847 0.318978683468538 no 2285 0.264785329973923 3495 1774255
SGTC_216 k038-0035 28.382 µM -0.630051637274809 0.318555882589969 no 2286 0.264330400135014 3517 4444231 YPR107C YTH1
SGTC_1545 lovastatin 49.4 µM -0.630933922800184 0.318287655508156 no 2287 0.264041865075229 3573 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1306 1185-0270 9.02 µM -0.631243752022046 0.318193485700276 no 2288 0.263940579282445 3572 1548076
SGTC_1561 5-methoxyflavone 52.9 µM -0.631410011265424 0.31814295754118 no 2289 0.263886235895674 3549 94525
SGTC_808 0711-0032 135 µM -0.632136907269178 0.317922084963461 no 2290 0.263648710149993 3559 4252555
SGTC_2936 9038235 15.59 µM -0.633654954625052 0.317461024262191 no 2291 0.263153014101597 3575 4749415
SGTC_861 0443-0273 110 µM -0.635138429485708 0.317010737323613 no 2292 0.262669067620587 3563 6149169
SGTC_2049 5262831 67.185 µM -0.635616297375187 0.316865745211728 no 2293 0.262513272225475 3578 763417
SGTC_1356 1502-0781 85.8 µM -0.636242455276601 0.316675802308203 no 2294 0.262309202658723 3554 567702
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.636459858071615 0.316609865197801 no 2295 0.262238368461233 3586 91467 include heat shock
SGTC_3217 9129673 49.47 µM -0.636496705719679 0.316598690079777 no 2296 0.262226363728613 3581 17248312
SGTC_1678 st019265 80.2 µM -0.638072975894173 0.316120797295373 no 2297 0.261713088552315 3614 5367020
SGTC_521 r062-0005 13.8 µM -0.638675244176127 0.315938282932226 no 2298 0.261517110298572 3518 2832033
SGTC_2202 7226349 200 µM -0.63903080992714 0.315830551582337 no 2299 0.261401444492107 3532 844334
SGTC_42 0133-0086 60.653 µM -0.640562722962143 0.315366582758893 no 2300 0.260903412637084 3544 162923 Model of phenazepam hydroxylation.
SGTC_930 2810-3379 265 µM -0.641143717781767 0.315190693563064 no 2301 0.260714656316524 3635 1015764
SGTC_775 4577-0580 57.3 µM -0.641284529602356 0.315148070782113 no 2302 0.260668919294341 3650 2006902
SGTC_2003 4023581 200 µM -0.64196605088821 0.314941813707269 no 2303 0.260447613056627 3597 16641307
SGTC_1290 0986-0249 10.2 µM -0.642158580265869 0.314883556650147 no 2304 0.260385111703244 3548 53329
SGTC_2612 dictamnine 15.46 µM -0.642437017767662 0.314799312982883 no 2305 0.260294735421969 3523 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1990 st072050 59.8 µM -0.643777793640441 0.314393784675372 no 2306 0.25985976780257 3588 17233948
SGTC_2653 dihydrofissinolide 100 µM -0.644100251404876 0.314296288142687 no 2307 0.259755213675828 3599 6857746
SGTC_2713 st079149 53.4 µM -0.644593673255511 0.314147124940251 no 2308 0.25959526796571 3583 3103253
SGTC_1757 st041620 31.8375 µM -0.645258262746264 0.313946265118689 no 2309 0.259379917613538 3583 5289815
SGTC_1225 1216-0074 20.6 µM -0.645361732593597 0.313914998237227 no 2310 0.259346398051489 3564 4241466
SGTC_2482 5981709 142.65 µM -0.646199684105869 0.313661832348546 no 2311 0.259075022048089 3564 877755
SGTC_1239 0337-0584 35.4 µM -0.64821335779287 0.313053810585454 no 2312 0.258423481738879 3647 914301 YML130C ERO1
SGTC_998 3996-0085 177 µM -0.64968069263014 0.312611073789847 no 2313 0.257949248961596 3608 715391
SGTC_2885 9057732 51.95 µM -0.649700949279358 0.312604963670603 no 2314 0.25794270530919 3615 6471414
SGTC_1323 1348-1351 11.2 µM -0.649940414406741 0.312532736453175 no 2315 0.257865355678191 3547 6989654
SGTC_2857 9024691 58.44 µM -0.651163365518383 0.312163983565599 no 2316 0.257470518011177 3595 16478292
SGTC_1458 k015-0034 6.33 µM -0.652133382687721 0.311871630860757 no 2317 0.257157565200616 3561 3598957
SGTC_2695 st077686 51.995 µM -0.652854998004673 0.311654220642989 no 2318 0.25692488166479 3578 2876092
SGTC_1942 st076330 65.2 µM -0.65319911451776 0.311550567396201 no 2319 0.256813960513881 3644 24208414
SGTC_646 4092-0839 27.3 µM -0.653285991353874 0.31152440110227 no 2320 0.256785960920474 3635 877796
SGTC_2073 5212005 126 µM -0.653446010273463 0.311476207753732 no 2321 0.256734392475374 3492 691789
SGTC_2166 5933061 31.504 µM -0.65375734526366 0.311382451374399 no 2322 0.256634075657234 3805 2877375
SGTC_3072 9116419 49.47 µM -0.653992997352336 0.311311494510309 no 2323 0.256558158583276 3563 17170162
SGTC_1635 st007035 42.4 µM -0.654549869028783 0.311143843533871 no 2324 0.256378804721602 3624 3716403
SGTC_86 0417-1630 471.922 µM -0.656026090945325 0.310699603957224 no 2325 0.255903668478521 3638 3634867
SGTC_2320 7373003 200 µM -0.656364115978102 0.310597920848301 no 2326 0.255794936557638 3601 5415828
SGTC_989 1501-0895 10.3 µM -0.657167535244285 0.310356298096156 no 2327 0.255536598900177 3599 2830112
SGTC_714 4296-0578 26.1 µM -0.658949702529547 0.309820615858206 no 2328 0.254964033882228 3606 1589775
SGTC_2342 7990637 118.86 µM -0.659393751289559 0.309687206843125 no 2329 0.2548214768486 3641 2033102 YER133W GLC7
SGTC_1343 1487-0095 224 µM -0.659759815671951 0.3095772461286 no 2330 0.254703987236373 3604 4560101 YGL055W OLE1
SGTC_1126 isoteolin 1.0172 µM -0.660051183074212 0.309489735542192 no 2331 0.254610492152848 3595 133323
SGTC_3233 9132340 49.47 µM -0.660226602046524 0.30943705463367 no 2332 0.254554211714135 3560 17682950
SGTC_418 lividomycin a 100 µM -0.663139681494882 0.308562786999323 no 2333 0.253620549228711 3629 72394 An antibiotic.
SGTC_1832 st054113 55 µM -0.664163877933377 0.30825566453675 no 2334 0.253292714953679 3611 1251267
SGTC_2742 clothiapine 36.27 µM -0.664661351687182 0.308106537096556 no 2335 0.253133559376172 3568 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3163 9099914 49.47 µM -0.665684376857005 0.307799964953237 no 2336 0.252806430783819 3638 16268368
SGTC_905 2-aminofluorene 215 µM -0.66612095596605 0.30766917517767 no 2337 0.252666895447575 3659 1539 An established DNA mutagen. YPR165W RHO1
SGTC_92 0063-0024 660.874 µM -0.66697697864189 0.307412800020197 no 2338 0.252393419259823 3675 3594437
SGTC_1914 st062367 72.6 µM -0.668257245148765 0.307029541202752 no 2339 0.251984699936823 3614 978205
SGTC_597 k018-0003 82.8 µM -0.669462458796667 0.306668942665621 no 2340 0.251600260288979 3694 6786234
SGTC_939 1165-0479 45.3 µM -0.671423585182576 0.306082575818131 no 2341 0.2509753621058 3580 1377347
SGTC_694 1315-0438 43.2 µM -0.674818488112569 0.305068691296664 no 2342 0.249895546374166 3581 6793154
SGTC_1078 idebenone 36.1 µM -0.675487408739935 0.304869094777001 no 2343 0.249683074183116 3650 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2378 9074213 121.43 µM -0.67702341483897 0.304410991898376 no 2344 0.249195549165706 3626 657714
SGTC_1479 0549-0158 134 µM -0.681574538120362 0.303055454430302 no 2345 0.247754009824163 3689 5440202
SGTC_3050 9093513 49.47 µM -0.683714123419771 0.302419120425799 no 2346 0.24707785165435 3653 25236664
SGTC_537 1334-0398 209 µM -0.685316870790164 0.301942840283614 no 2347 0.246571994048052 3645 5846986
SGTC_916 4466-0038 42 nM -0.689853572430005 0.300596522732863 no 2348 0.245143137463591 3705 5722064 YGL116W CDC20
SGTC_185 k048-0037 25.491 µM -0.690242871180622 0.300481120288729 no 2349 0.245020733685718 3659 6827589
SGTC_489 paxilline 115 µM -0.691247064509333 0.300183532939146 no 2350 0.244705145870563 3643 105008 A toxic potassium channel blocker.
SGTC_1872 amphotericin b 148 nM -0.691941162189503 0.299977918706881 no 2351 0.244487139791581 3674 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3273 9137859 49.47 µM -0.692836638714798 0.299712743722869 no 2352 0.24420603816574 3723 2377234
SGTC_234 nsc-17383 10.7 µM -0.693368479460385 0.299555301468229 no 2353 0.244039169015118 3687 408974
SGTC_510 ag-490 170 µM -0.694057431878258 0.299351404767242 no 2354 0.243823096335016 3766 5328779
SGTC_1190 1486-1332 13 µM -0.695480759821404 0.298930367793365 no 2355 0.243377032350225 3659 4150046
SGTC_1559 coumarin 343 70.1 µM -0.69564995927986 0.2988803345181 no 2356 0.243324035412769 3678 108770 A hepatotoxic, DNA x-linker.
SGTC_1699 st031318 29.054 µM -0.697154298504981 0.298435659948778 no 2357 0.242853118118124 3725 5340658
SGTC_1433 4060-0023 7.6 µM -0.697484937742484 0.298337965142708 no 2358 0.242749681193437 3676 3840627
SGTC_3060 1327-0027 12.5 µM -0.697710627573327 0.298271288362762 no 2359 0.242679090256853 3606 16000455 YPR107C YTH1
SGTC_1146 3579-1023 7 µM -0.698331422529387 0.298087918526964 no 2360 0.242484976254632 3718 X1146
SGTC_3319 9138450 16.7555 µM -0.698494947161103 0.298039625321756 no 2361 0.24243385836076 3642 2029690
SGTC_1905 st060207 84.5 µM -0.698700955564943 0.29797879059609 no 2362 0.242369468326066 3613 1948547
SGTC_1211 1056-0033 32.3 µM -0.699092475940835 0.297863189388065 no 2363 0.242247120170629 3681 6741922
SGTC_257 daunorubicin 18.5 µM -0.700036223449552 0.297584620420062 no 2364 0.241952341451874 3711 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3197 9113331 49.47 µM -0.701415399779273 0.297177738555623 no 2365 0.241521907094462 3696 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2711 st079103 59.1 µM -0.703224054562257 0.29664453858784 no 2366 0.240958065397894 3669 54693780
SGTC_2702 st077768 96.8 µM -0.703540098379831 0.296551412368027 no 2367 0.240859613394018 3616 6484119
SGTC_1281 0884-0031 11.8 µM -0.703977310185461 0.296422604588214 no 2368 0.240723451977977 3705 1548255
SGTC_146 3448-8650 53.125 µM -0.705348760064496 0.296018725684896 no 2369 0.240296611568154 3685 2891488 YIL048W NEO1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.707543743930386 0.295372850094201 no 2370 0.239614319248065 3710 229346 A bile salt which induces apoptosis.
SGTC_2258 7960471 200 µM -0.707914375911863 0.295263855379558 no 2371 0.239499215847535 3640 2974708
SGTC_1628 st004252 77.7 µM -0.708285978194674 0.295154593908922 no 2372 0.239383841425465 3674 692968
SGTC_2536 dehydroabietamide 32.04 µM -0.710636639286366 0.29446386552399 no 2373 0.238654716151122 3694 3983547
SGTC_1974 st069448 26.9 µM -0.711094952574034 0.294329279738347 no 2374 0.238512698783541 3659 6323587 YNR016C ACC1
SGTC_2242 6630449 61.2675 µM -0.71204356808854 0.294050804752703 no 2375 0.238218898681624 3729 691249 YDR170C SEC7
SGTC_687 k029-0044 34.9 µM -0.712865846567866 0.293809515775451 no 2376 0.237964387513345 3704 5829338
SGTC_45 0kpi-0036 14.9 µM -0.713805842627599 0.293533796075378 no 2377 0.237673623171108 3675 2795021
SGTC_32 0928-0142 34.1 µM -0.713834545733002 0.293525378764379 no 2378 0.237664747649103 3665 2244242
SGTC_1393 3470-5649 58.2 µM -0.714538742290311 0.29331890507033 no 2379 0.237447054239849 3652 4108395
SGTC_373 0844-0104 25.9 µM -0.715941280888145 0.292907874914047 no 2380 0.237013803581814 3744 5375804
SGTC_2475 5812728 15.03 µM -0.717138580136477 0.292557204169858 no 2381 0.236644296326886 3690 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_743 1275-0778 158 µM -0.717160047681714 0.292550918432954 no 2382 0.236637673964459 3707 2849257 YMR203W TOM40
SGTC_2616 abietic acid 100 µM -0.718270769199538 0.292225782779758 no 2383 0.236295174930442 3695 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3333 9141820 12.094 µM -0.718458080022951 0.292170968839494 no 2384 0.236237443188815 3707 1939433
SGTC_2813 7971799 71.43 µM -0.721185688664395 0.291373314255313 no 2385 0.23539763787675 3754 2234054
SGTC_69 0096-0274 206.684 µM -0.721444654756689 0.291297635748813 no 2386 0.235317990363705 3816 6741392
SGTC_2988 9073640 71.4286 µM -0.722512293831544 0.290985733012806 no 2387 0.234989784841942 3728 9102229
SGTC_591 4299-0174 154 µM -0.723462513053191 0.290708264915405 no 2388 0.234697888491892 3698 5509088
SGTC_1836 st055642 81 µM -0.723916808368283 0.290575652466133 no 2389 0.234558405097085 3731 8571
SGTC_493 zm226600 134 µM -0.725249900624979 0.290186675619231 no 2390 0.23414936735103 3722 5240098 A potassium channel opener. YCR052W RSC6
SGTC_184 1494-0393 24.714 µM -0.728129873549313 0.289347175475318 no 2391 0.233267044194507 3712 3090647
SGTC_2200 6600604 21.907 µM -0.728388531780444 0.289271833558008 no 2392 0.233187890746231 3684 2904777
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.729328421483134 0.288998140330257 no 2393 0.232900395409259 3712 803109
SGTC_1311 1190-0148 100 µM -0.730129478928506 0.288764970867744 no 2394 0.232655521861556 3794 1961333
SGTC_2486 5283202 22.39 µM -0.730313425504197 0.288711440742937 no 2395 0.232599311835113 3751 1377751
SGTC_869 0564-0080 44.1 µM -0.730690700510088 0.28860166491148 no 2396 0.232484048519483 3750 6843321
SGTC_1257 0669-0121 16 µM -0.731578525344173 0.288343411840291 no 2397 0.232212929745561 3758 4307855
SGTC_446 go6976 132 µM -0.73158513292384 0.288341490216845 no 2398 0.232210912621218 3686 3501 A protein kinase C inhibitor.
SGTC_1813 st051246 8.6015 µM -0.733651972802806 0.287740706172409 no 2399 0.231580438251664 3668 5291959
SGTC_60 0986-0278 202 µM -0.734585531513086 0.287469535610061 no 2400 0.231295976122069 3570 3110598
SGTC_3005 9076496 71.4286 µM -0.737653666652417 0.286579187487191 no 2401 0.230362467252297 3748 21368410
SGTC_1077 5-fluorocytosine 377 nM -0.737774040082221 0.286544282768741 no 2402 0.230325885504292 3763 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2627 acetyl isogambogic acid 100 µM -0.739112886739397 0.286156193042468 no 2403 0.229919226146102 3724 6857789 A caspase activator and apoptosis inducer.
SGTC_666 0272-0154 136 µM -0.739455168987136 0.286057016225379 no 2404 0.229815326373431 3781 6870312
SGTC_2394 5221648 200 µM -0.741750777028232 0.285392282667774 no 2405 0.229119174382061 3815 788586
SGTC_1939 st074455 53.6 µM -0.741835200590743 0.285367850375978 no 2406 0.229093595180382 3738 1644229
SGTC_1184 1269-1718 139 µM -0.741865561952601 0.285359064000846 no 2407 0.229084396488556 3776 5403821
SGTC_3221 9128209 49.47 µM -0.745475658318235 0.284315245893635 no 2408 0.227992110538614 3779 16460723
SGTC_2330 7979373 200 µM -0.745493323642165 0.284310142657065 no 2409 0.227986772856371 3713 1863007
SGTC_3170 9103054 49.47 µM -0.746000061290516 0.284163772697535 no 2410 0.227833689006726 3732 16432970
SGTC_2981 9013952 38.96 µM -0.746668243431118 0.283970824983589 no 2411 0.227631921732181 3666 2996344
SGTC_655 k060-0012 42 µM -0.748541099671622 0.283430343740969 no 2412 0.227066922158971 3752 5994525
SGTC_542 3381-0244 89.3 µM -0.751782655364645 0.282496041212489 no 2413 0.226090887106845 3758 1112843
SGTC_160 3453-0671 289.699 µM -0.752368616404529 0.282327309842284 no 2414 0.225914707162803 3779 5322268
SGTC_403 arphamenine a 50 µM -0.753623789854901 0.281966037578174 no 2415 0.225537577580928 3725 5487158 An arginine aminopeptidase inhibitor.
SGTC_111 0083-0039 52.457 µM -0.75387583898924 0.281893517998172 no 2416 0.225461889846371 3665 759313
SGTC_2619 obliquin 87.91 µM -0.755008948278707 0.281567610835018 no 2417 0.225121806576938 3733 6708593 A bioactive alkalod. YER133W GLC7
SGTC_155 k072-0202 43.6 µM -0.75531091306671 0.281480789796784 no 2418 0.225031226107629 3688 5857737
SGTC_3287 9117173 37.0625 µM -0.757511484575922 0.280848470921731 no 2419 0.224371744019415 3758 2789709
SGTC_2855 9016525 58.44 µM -0.762185072647652 0.279507830459958 no 2420 0.222974776989607 3757 43811474
SGTC_96 0929-0093 37.281 µM -0.762894426659306 0.279304620909555 no 2421 0.222763180155908 3751 6991579
SGTC_2833 9001315 45.46 µM -0.763316396131641 0.279183772837802 no 2422 0.222637363026323 3775 2989378
SGTC_1380 2291-0730 164 µM -0.764486704173844 0.278848740726128 no 2423 0.222288628511245 3803 2999191
SGTC_801 0866-0028 10.1 µM -0.764790407659613 0.278761829430242 no 2424 0.22219818031639 3785 6849771
SGTC_756 0508-1999 28.3 µM -0.76727640892911 0.278050902732555 no 2425 0.221458595809147 3777 6753853
SGTC_354 2783-3500 4.88 µM -0.767336165110362 0.278033825031712 no 2426 0.221440835704407 3796 6740761
SGTC_2511 berberine 10.47 µM -0.767737374862856 0.277919176673423 no 2427 0.221321613444486 3772 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_306 1672-3436 11.6 µM -0.769942178963947 0.277289551356348 no 2428 0.220667096140432 3788 6797378
SGTC_2741 miltefosine 3.04 µM -0.770726141601394 0.277065843601061 no 2429 0.220434636769743 3745 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3338 9144300 39.5675 µM -0.771172363648457 0.276938551312436 no 2430 0.220302386411461 3820 4901274
SGTC_822 1487-0950 154 µM -0.77331373232899 0.276328088863511 no 2431 0.219668365332782 3779 1958375
SGTC_1767 st044992 70.3 µM -0.774355745150557 0.276031270292165 no 2432 0.219360223283935 3818 9600693
SGTC_2687 chenodiol 100 µM -0.775067422200661 0.275828638269277 no 2433 0.219149910332441 3824 5702181 A cholesterol synthesis inhibitor.
SGTC_1949 st076024 69.1 µM -0.775562429615621 0.275687740551647 no 2434 0.219003695413371 3753 2921930
SGTC_1540 guanosine 70.6 µM -0.775950296674403 0.275577363734696 no 2435 0.218889166747831 3703 6802 Guanosine is a purine nucleoside
SGTC_3268 9137683 49.47 µM -0.778187465614069 0.274941148465028 no 2436 0.218229252538681 3816 1953228
SGTC_3341 9147222 25.867 µM -0.778471038890924 0.274860556447899 no 2437 0.218145686783016 3808 1939759
SGTC_391 gliotoxin 8.33 µM -0.779538945447056 0.274557160078974 no 2438 0.217831152656501 3898 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_154 3389-1638 511.116 µM -0.780378439940765 0.274318772504238 no 2439 0.217584077247008 3754 5238686
SGTC_1440 4100-1550 40 µM -0.781750346648234 0.273929418253553 no 2440 0.217180653515917 3808 742806
SGTC_286 k060-0067 22.9 µM -0.782016926669321 0.273853793169073 no 2441 0.217102312999494 3794 5985051
SGTC_917 harmaline 728.087 nM -0.782392794717793 0.273747182116348 no 2442 0.216991883490544 3825 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_840 0245-0196 390 µM -0.784399968732157 0.273178215879315 no 2443 0.216402728373696 3909 3827528
SGTC_2801 7907800 81.82 µM -0.784516721845365 0.27314513834528 no 2444 0.216368486968822 3875 6620925
SGTC_1457 k015-0032 57.3 µM -0.78562371023995 0.272831614131976 no 2445 0.216043984782336 3814 4302660
SGTC_1358 1509-0022 2.48 µM -0.786126367504228 0.272689309151602 no 2446 0.215896729126858 3845 3258434
SGTC_2753 fluvastatin 17.09 µM -0.788165421006342 0.272112420157711 no 2447 0.215299976252978 3852 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1852 st056254 31.4 µM -0.788207094893057 0.27210063611205 no 2448 0.215287789891767 3745 442583
SGTC_1262 0737-0114 49.6 µM -0.788773344905942 0.271940543821915 no 2449 0.215122245605814 3848 765919
SGTC_1256 0570-0116 285 µM -0.789926743129353 0.271614595804577 no 2450 0.214785276065723 3840 410638
SGTC_303 1348-1668 34.2 µM -0.790212107285857 0.271533982496322 no 2451 0.214701953223832 3822 5380509
SGTC_2084 5306078 60.6385 µM -0.790376928144506 0.271487427226383 no 2452 0.214653836108932 3766 679340
SGTC_2989 9073649 71.4286 µM -0.791698169541034 0.271114373364998 no 2453 0.214268344948239 3757 21367202
SGTC_726 3448-4391 34.2 µM -0.792089016824039 0.271004066251183 no 2454 0.21415438687113 3885 1356692
SGTC_3239 9133757 49.47 µM -0.792101545016051 0.271000530844884 no 2455 0.214150734650167 3819 17036923
SGTC_1569 carminic acid 40.6 µM -0.792831705233597 0.270794522271387 no 2456 0.213937940818884 3869 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_315 k915-0449 187 µM -0.794009546937266 0.270462368974444 no 2457 0.21359493676074 3853 20970215 YNL149C PGA2
SGTC_17 0960-0276 49.807 µM -0.79502252801173 0.270176869574339 no 2458 0.213300198884701 3809 6821114
SGTC_3216 9129716 49.47 µM -0.795611276716771 0.270011005454154 no 2459 0.213129005055321 3815 8056934
SGTC_2393 9031399 185.94 µM -0.79598570009649 0.269905548245345 no 2460 0.213020173531216 3850 1526623 YDL150W RPC53
SGTC_1165 k072-0275 30.3 µM -0.797122090307128 0.269585607616467 no 2461 0.212690064027543 3814 6153523 YGL055W OLE1
SGTC_2838 9002687 71.43 µM -0.79842197760592 0.269219868976252 no 2462 0.212312826823298 3825 6457060
SGTC_2023 5144124 124 µM -0.798754820848975 0.269126259640549 no 2463 0.212216296094866 3830 2830192
SGTC_1645 Cervolide 78 µM -0.799182185746939 0.269006090843794 no 2464 0.212092389955338 3816 23173 A fragrance.
SGTC_1054 3429-0080 167 µM -0.800181737055268 0.268725136749245 no 2465 0.211802754720981 3822 1162877
SGTC_1464 k208-0027 110 µM -0.801590340801867 0.268329456517032 no 2466 0.211394983430132 3811 X1464
SGTC_999 SEC7.066 22.7 µM -0.802108208913458 0.268184059808779 no 2467 0.211245183450963 3824 740511 YDR170C SEC7
SGTC_2289 7946404 165.07 µM -0.803411174841655 0.267818414395293 no 2468 0.210868559087162 3869 1246120 YPR165W RHO1
SGTC_983 1491-0821 12.2 µM -0.806047677383056 0.267079313696729 no 2469 0.21010767946393 3845 46495113
SGTC_2657 nystatin 74.44 µM -0.807152015138118 0.266770036846939 no 2470 0.209789453754002 3874 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2639 lactacystin 53 µM -0.807661091565605 0.266627527712426 no 2471 0.209642853877161 3864 3870 A proteasome inhibitor.
SGTC_2133 5320837 200 µM -0.807916646310665 0.266556003094586 no 2472 0.209569283924497 3839 2841355
SGTC_1943 st076331 65.2 µM -0.808275322532063 0.266455633224487 no 2473 0.209466052635381 3875 24208415
SGTC_1413 3910-0535 34.4 µM -0.808420282429712 0.266415073914319 no 2474 0.209424339940427 3851 2876951
SGTC_1555 citronellol 128 µM -0.809350293310212 0.266154934204227 no 2475 0.209156842489937 3781 8842 A terpine precursor.
SGTC_1277 0873-0036 22 µM -0.810334715097315 0.265879715036146 no 2476 0.20887391420293 3895 5965735
SGTC_639 0833-0042 114 µM -0.811773051758483 0.265477852330123 no 2477 0.208460933914145 3830 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_858 0438-0351 2.77 µM -0.812631087455218 0.265238269098742 no 2478 0.208214801155752 3853 2799119
SGTC_1548 st061468 90.8 µM -0.812727686616598 0.265211303275777 no 2479 0.208187101842143 3841 390799
SGTC_402 epigallocatechin gallate 10 µM -0.815836126716303 0.264344320609756 no 2480 0.207296933918603 3822 65064 An antioxidant.
SGTC_2551 apiole 73.87 µM -0.816314999278278 0.264210885463264 no 2481 0.207159998925106 3679 10659 A possible DNA adduct former.
SGTC_1756 st041558 35.5 µM -0.816841510392122 0.264064215704596 no 2482 0.20700950332026 3908 3955792
SGTC_690 glyoxal 20.3 µM -0.817477462360639 0.263887114431321 no 2483 0.206827811912287 3713 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2269 7935389 174.42 µM -0.817810230114308 0.263794468688308 no 2484 0.206732777834023 3806 97605
SGTC_2764 methyldopa 94.69 µM -0.818143954047971 0.263701573396025 no 2485 0.206637496654077 3830 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_387 norethindrone acetate 66.7 µM -0.818587586703608 0.263578109784601 no 2486 0.206510875819683 3860 541197
SGTC_390 dec-rvkr-cmk 16.7 µM -0.81914402586413 0.26342329366921 no 2487 0.206352122952639 3899 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2566 crystal violet carbinol 226 nM -0.819412739223975 0.263348547118901 no 2488 0.20627548455955 3900 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_105 0111-0055 734.78 µM -0.820089212259793 0.263160424212593 no 2489 0.206082625778268 3875 5179370
SGTC_2956 9076196 2.52 µM -0.821346343208059 0.262811006424115 no 2490 0.205724508692426 3864 16423868
SGTC_235 0330-0087 5 mM -0.822294717509373 0.262547564220139 no 2491 0.20545459122947 3882 46494818 YHR062C RPP1
SGTC_1873 rapamycin 2 nM -0.823437425430366 0.262230319090325 no 2492 0.205129643850815 3837 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1844 rapamycin 4 nM -0.823760427106464 0.262140681126035 no 2493 0.205037848524743 3808 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_561 1550-0330 72.9 µM -0.824731914370791 0.261871173039171 no 2494 0.204761904306178 3812 6812934
SGTC_1149 3909-7961 23.3 µM -0.825092805553588 0.261771091528383 no 2495 0.204659451963144 3898 735261
SGTC_2413 inermin 26.06 µM -0.825315721843333 0.26170928270153 no 2496 0.204596184148246 3977 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2357 9067248 200 µM -0.826924486076739 0.26126343680709 no 2497 0.204139931903063 3891 9150235
SGTC_2719 novobiocin 32.65 µM -0.828176674471173 0.260916681058694 no 2498 0.203785225831222 3860 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_941 3237-0776 460 µM -0.829247003301804 0.260620473559467 no 2499 0.203482326353286 3912 760008
SGTC_248 streptozotocin 5.23457 mM -0.829754540594964 0.260480075985568 no 2500 0.203338788915683 3861 5300 DNA alkylating agent.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.835874897258438 0.258790103423816 no 2501 0.201612642905407 3922 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2446 5162541 200 µM -0.836017047316886 0.258750920025318 no 2502 0.201572656406032 3839 1549321
SGTC_1325 1431-0015 227 µM -0.836283669705944 0.258677434342807 no 2503 0.201497668928071 3850 1103340
SGTC_253 dyclonine 31.25 µM -0.837812745539274 0.258256203684806 no 2504 0.201067939665668 3970 3180 An oral anasthetic.
SGTC_49 0717-0965 32.132 µM -0.839011222089861 0.257926295409974 no 2505 0.200731506131085 3924 5889349 YGL099W LSG1
SGTC_165 k038-0023 64.381 µM -0.839623766366476 0.257757762962236 no 2506 0.20055968469723 3905 46368543
SGTC_575 k072-0246 11.9 µM -0.842108267583821 0.257074775964825 no 2507 0.199863676969581 3922 6796779
SGTC_263 alizarin 107.927 µM -0.843226607635116 0.256767652831326 no 2508 0.199550860076157 3894 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.843395635253849 0.256721250394111 no 2509 0.199503606101568 3956 688788
SGTC_2846 9008642 19.48 µM -0.845034044037884 0.25627169131979 no 2510 0.199045915742714 3967 2992898
SGTC_3093 9117344 49.47 µM -0.846894369572983 0.25576173901283 no 2511 0.198527000543866 3949 24824913
SGTC_558 k064-0027 21.3 µM -0.847177654653987 0.255684131429247 no 2512 0.198448053270262 3929 5088526
SGTC_2979 9012552 45.46 µM -0.850215091649357 0.254852781430585 no 2513 0.19760275636101 3941 17100905
SGTC_3082 9117008 49.47 µM -0.85156314849225 0.254484270548065 no 2514 0.197228300191979 3973 41448529
SGTC_2692 st077426 47.7 µM -0.851599430647442 0.25447435615472 no 2515 0.197218227861092 3911 25238571
SGTC_2787 5284540 71.43 µM -0.851882201481951 0.254397093665338 no 2516 0.197139738188677 3947 736958
SGTC_162 k030-0015 37.8 µM -0.853693936884909 0.253902358583736 no 2517 0.196637297231384 3982 1809920 YMR134W ERG29
SGTC_1856 st057054 55.7 µM -0.853737146918116 0.253890565281116 no 2518 0.196625323453626 3906 1266018
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.854530863822264 0.253673987496668 no 2519 0.196405457982615 3910 77254
SGTC_688 0527-0193 473 µM -0.854648102003831 0.253642005493699 no 2520 0.196372994771586 3927 4007154
SGTC_2628 lathosterol 100 µM -0.855089052928811 0.253521735200931 no 2521 0.196250924739897 3998 6710616
SGTC_1250 0485-0349 40.2 µM -0.855592953074713 0.253384332069231 no 2522 0.19611148459038 3923 6842794 YDL195W SEC31
SGTC_237 nikkomycin 200 µM -0.858357935987 0.252631075706818 no 2523 0.195347423566733 3906 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2055 5235184 200 µM -0.858696856091431 0.252538825891832 no 2524 0.19525389272686 3966 2836034
SGTC_585 0kpi-0023 191 µM -0.859718122069801 0.252260957411232 no 2525 0.194972221369269 3821 64601
SGTC_2440 5628896 157.78 µM -0.86049747580785 0.252049017492229 no 2526 0.194757437173679 3928 5522048
SGTC_2092 5303694 80.6725 µM -0.860958508753163 0.251923686974789 no 2527 0.194630447645029 3914 1963699
SGTC_1082 camptothecin 424.86 nM -0.86196902484645 0.251649096096578 no 2528 0.19435228165892 3838 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1691 st019933 84.6 µM -0.862010462003573 0.251637839616006 no 2529 0.194340880371264 3854 6176082
SGTC_3143 9086658 49.47 µM -0.862086236993662 0.251617255887315 no 2530 0.194320032203227 4004 25236626
SGTC_728 3030-5151 22.5 µM -0.86245164571408 0.251518007735101 no 2531 0.194219515480313 3951 3125388
SGTC_1590 st077108 57.8 µM -0.863664922781579 0.251188619663702 no 2532 0.193885994108036 3915 5489485
SGTC_2036 5160441 105 µM -0.863899787054408 0.251124883603153 no 2533 0.193821471913062 3905 134534 YIL048W NEO1
SGTC_1494 4358-1428 177 µM -0.864154904931731 0.25105566093479 no 2534 0.193751400455677 3924 1564571
SGTC_381 3461-2219 42.7 µM -0.864687697149021 0.250911127780486 no 2535 0.193605111928824 3908 2883159
SGTC_2419 paclitaxel 166.5 µM -0.865502292238029 0.250690233751092 no 2536 0.193381579175328 3858 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_662 k832-1615 104 µM -0.865644045690425 0.250651804942159 no 2537 0.193342696751885 3971 5878478
SGTC_3342 9147791 14.508 µM -0.866783127078578 0.250343117721839 no 2538 0.193030424352651 3841 1838168
SGTC_1058 3448-5425 97.3 µM -0.867144249559423 0.25024529683601 no 2539 0.19293148909927 3794 7279705
SGTC_2083 5306046 65.942 µM -0.867885268005827 0.250044633185976 no 2540 0.192728572297467 3950 539837
SGTC_1991 st073000 8.92 µM -0.868224674552038 0.249952752306102 no 2541 0.192635674457978 4018 4301969 YIL048W NEO1
SGTC_958 1222-0007 33 µM -0.868315314589724 0.249928218137569 no 2542 0.192610870304763 4015 7312461
SGTC_107 0358-0022 2.6945 µM -0.868819901351613 0.249791661499636 no 2543 0.192472822999196 3960 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3023 9089636 49.47 µM -0.869193580446833 0.249690558024658 no 2544 0.192370629046737 4000 17249241
SGTC_246 cycloheximide 667 µM -0.870539778609928 0.249326507807053 no 2545 0.192002745237918 3789 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2312 7706453 155.7 µM -0.874392390708309 0.248286213363245 no 2546 0.19095229993737 3961 976098
SGTC_269 exalamide 29 µM -0.877052009703879 0.247569407192092 no 2547 0.190229194627113 3860 3316 A derivative of salicylamide.
SGTC_2516 gossypol 71.55 µM -0.877414636266914 0.247471759750404 no 2548 0.190130733101711 3975 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1320 1313-0481 95.3 µM -0.878132090822024 0.247278625508863 no 2549 0.189936019838602 3938 6813365 YLR208W SEC13
SGTC_369 0957-0393 4.5 µM -0.878307808503131 0.247231335705752 no 2550 0.189888349710856 3971 6997992
SGTC_587 k089-0003 57 µM -0.878841457736116 0.247087747666505 no 2551 0.189743622085926 3839 9659696
SGTC_1026 k007-1105 30.6 µM -0.880020914859503 0.246770551578513 no 2552 0.189423989746931 3928 7066794
SGTC_1888 azatryptophan 97.5 µM -0.880480932738331 0.246646896266177 no 2553 0.189299414992099 3992 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2353 9059630 146.67 µM -0.881426770818933 0.246392754135224 no 2554 0.189043436607382 4001 4779114
SGTC_2640 pentamidine 10.38 µM -0.881895573176337 0.246266841242433 no 2555 0.188916640604246 3946 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3172 9105863 49.47 µM -0.882302377630552 0.246157607967115 no 2556 0.188806655517939 3957 2348785
SGTC_316 k060-0003 58.6 µM -0.883020522675026 0.245964838378521 no 2557 0.188612591633769 3953 6152314
SGTC_260 nsc-65238 3.989 µM -0.885300176993895 0.245353454445424 no 2558 0.187997377277813 3923 3246252
SGTC_2985 9022375 71.43 µM -0.886568752062074 0.245013587443198 no 2559 0.187655561793937 4022 4939335
SGTC_2067 5224629 34.075 µM -0.887380858943622 0.244796146970939 no 2560 0.187436942623753 3957 2835000
SGTC_925 2064-1272 59.6 µM -0.889114653388983 0.24433227377281 no 2561 0.186970732235635 3944 6815817
SGTC_740 k014-0057 261 µM -0.889215241112467 0.24430537627853 no 2562 0.186943706636518 3950 4012779
SGTC_2541 muurolladie-3-one 83.07 µM -0.891625150098317 0.243661435976571 no 2563 0.186296942541228 3990 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2399 5884133 200 µM -0.891801891694709 0.243614245794035 no 2564 0.186249563795615 3988 722445
SGTC_757 1066-0008 322 µM -0.892078303374012 0.243540453496112 no 2565 0.186175481672964 3993 6842497
SGTC_1196 1588-0294 184 µM -0.892234961174337 0.243498636676689 no 2566 0.186133503342278 3972 6144269
SGTC_2683 piperine 63.03 µM -0.892344663846791 0.243469355944525 no 2567 0.186104110692357 3932 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2836 9010338 19.48 µM -0.894410290613371 0.242918374930215 no 2568 0.185551204280108 3973 2994051
SGTC_2431 5490079 200 µM -0.894862299376294 0.242797897072331 no 2569 0.185430351153143 4021 5722345
SGTC_2101 5377231 179.231 µM -0.896897910534498 0.242255728761546 no 2570 0.184886697581202 3998 2844213
SGTC_2098 5376439 882.5 nM -0.897249527098763 0.24216214508368 no 2571 0.184792891272275 3988 2844116
SGTC_1227 3909-8010 46.6 µM -0.897376482851453 0.242128360290974 no 2572 0.184759028549915 3961 15982272
SGTC_2656 pseudo-anisatin 100 µM -0.897737236506963 0.242032372388148 no 2573 0.184662826310298 3994 6708809 A neurotoxin.
SGTC_2952 9073731 13.78 µM -0.898445555865533 0.241843965634696 no 2574 0.184474029294351 4045 16457353
SGTC_1321 1326-2144 215 µM -0.899294258749824 0.241618322931804 no 2575 0.184247972318881 3981 3513030
SGTC_2001 4023502 57.655 µM -0.901637530535236 0.240995916493489 no 2576 0.183624723741084 3996 108941 YCR052W RSC6
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.902985611738421 0.240638242368616 no 2577 0.18326676565684 4019 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2405 ticlatone 3.52 µM -0.903879487308981 0.240401237912882 no 2578 0.18302965359656 3850 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2784 7567673 72.73 µM -0.904620627839503 0.240204826471062 no 2579 0.182833201692862 3943 3471247
SGTC_1279 0874-0590 65.2 µM -0.905072701706735 0.240085064238577 no 2580 0.182713436474646 4033 3523074
SGTC_669 0108-0021 26.2 µM -0.905273330241482 0.240031924679959 no 2581 0.18266030085617 3911 17201
SGTC_598 3937-0236 20.2 µM -0.905828386968046 0.23988494277263 no 2582 0.182513346710445 4041 1379313
SGTC_2887 9044784 58.44 µM -0.907916173024986 0.239332526031968 no 2583 0.181961256063082 3961 6465546
SGTC_122 0236-0016 402.397 µM -0.908153117226963 0.23926987583251 no 2584 0.181898664988666 3988 6808838
SGTC_835 0312-0010 67.2 µM -0.910179133519469 0.238734544742593 no 2585 0.181364023374769 3933 1626196
SGTC_1753 st043925 64 µM -0.910748138523508 0.238584315395382 no 2586 0.18121404686553 4031 670181
SGTC_2635 hydroquinidine 100 µM -0.910829995893291 0.238562707577711 no 2587 0.181192477556109 3909 442912 An experimental heart treatment.
SGTC_1424 4048-1941 275 µM -0.915483351382805 0.237336128312198 no 2588 0.179968969324742 4058 X1424
SGTC_4 0960-0234 25.671 µM -0.916316897056611 0.237116780084431 no 2589 0.17975035405152 3986 6821112
SGTC_1945 st075991 56.6 µM -0.916740288437537 0.237005406967433 no 2590 0.17963937448082 4017 1084980
SGTC_946 3434-1334 87.4 µM -0.917306621370821 0.236856478030505 no 2591 0.179490994327676 3979 4047976
SGTC_1518 st038567 90.8 µM -0.917752633235829 0.236739226229993 no 2592 0.179374192734347 3953 77966
SGTC_1260 0700-1617 7.75 µM -0.918075336703281 0.236654410811339 no 2593 0.179289712949908 4024 2853078
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.918855150676818 0.236449523098535 no 2594 0.179085670582292 4053 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1301 naphtanilide LB 4.81 µM -0.920812149055296 0.23593577310066 no 2595 0.178574255471996 4058 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1295 1013-0063 9.78 µM -0.922376664256453 0.235525500462006 no 2596 0.178166068797374 4003 6826038
SGTC_877 0771-0151 33.1 µM -0.924766960008585 0.2348994390247 no 2597 0.177543570204032 4032 6166523
SGTC_1268 0828-0275 2.46 µM -0.925470335987951 0.234715387493902 no 2598 0.177360653518744 4051 745337
SGTC_2019 4016004 108 µM -0.925816022334262 0.234624961402484 no 2599 0.177270799560256 4040 45595336
SGTC_1831 st055328 12 µM -0.925821338846218 0.234623570837328 no 2600 0.177269417868314 3997 1103068
SGTC_393 acivicin 6.25 µM -0.926778839665672 0.234373205176058 no 2601 0.177020686838624 3849 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2849 9019321 12.99 µM -0.927349429555324 0.234224078648926 no 2602 0.176872568990226 4024 16489627
SGTC_3025 9087895 49.47 µM -0.928001268977321 0.234053781450866 no 2603 0.176703455685267 4014 17173641
SGTC_47 0149-0135 24.25 µM -0.929662060883386 0.23362019910055 no 2604 0.17627304185598 4038 5239155
SGTC_3291 9121177 71.43 µM -0.930105721664926 0.233504448161037 no 2605 0.176158174308337 4031 17015612
SGTC_982 1491-0518 27.5 µM -0.930840669527972 0.233312770536504 no 2606 0.175967994336889 3934 3091256
SGTC_823 0417-1665 178 µM -0.931539922934638 0.233130483266035 no 2607 0.175787171638522 3990 3429856
SGTC_2130 NSC 7 2.4545 µM -0.931716803323941 0.233084385128926 no 2608 0.175741450099483 4070 21448
SGTC_1829 berberine 14.4 µM -0.933164467923939 0.232707288582474 no 2609 0.175367528704234 4011 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2596 sinensetin 100 µM -0.933745171454063 0.23255611870837 no 2610 0.175217678993075 4037 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1733 st037357 54.9 µM -0.934547656817075 0.232347304046477 no 2611 0.175010732490653 3923 1272339 YGL099W LSG1
SGTC_1244 0416-0015 52.5 µM -0.93566165464975 0.232057603720837 no 2612 0.174723709713169 3988 96201
SGTC_2823 7987624 58.44 µM -0.938089196405393 0.231427007274677 no 2613 0.174099286692515 4025 2239440
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.938445331514894 0.231334575388337 no 2614 0.174007799506696 4059 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3354 9151612 71.43 µM -0.939340763271772 0.231102264564936 no 2615 0.17377790802072 4048 27261949
SGTC_35 0133-0054 64.071 µM -0.940008996029986 0.230928983119404 no 2616 0.173606473124925 4031 99677
SGTC_2949 9072542 2.23 µM -0.940796900171233 0.230724762551551 no 2617 0.173404474872561 4097 16457352
SGTC_794 k038-0031 316 µM -0.942342993269832 0.230324316804812 no 2618 0.173008531612005 4014 6624242
SGTC_824 1304-0008 100 µM -0.943141266325427 0.23011771237084 no 2619 0.172804325300021 4047 768245
SGTC_1811 st050069 61.5 µM -0.943890387895437 0.229923923384214 no 2620 0.172612832217315 3952 3877702
SGTC_2389 9091542 195.52 µM -0.945223834226315 0.229579202542952 no 2621 0.172272306896387 4013 3626624 YOL127W RPL25
SGTC_3250 9135583 49.47 µM -0.945647089000756 0.229469843830427 no 2622 0.172164309009471 4064 7699353
SGTC_3316 9136639 10.545 µM -0.945787072862656 0.229433681839117 no 2623 0.172128600171801 4048 4903665
SGTC_1657 st012939 43.4 µM -0.949023968216657 0.228598386905382 no 2624 0.171304210981087 4045 24207257
SGTC_2766 oltipraz 83.91 µM -0.949738944514621 0.228414114723902 no 2625 0.171122458042915 3983 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3135 9127742 49.47 µM -0.953664592793045 0.227403838599995 no 2626 0.170126724135069 4114 3643468
SGTC_1726 st035556 14.5795 µM -0.953884813010389 0.227347238999567 no 2627 0.170070975863407 4147 5919439
SGTC_1630 st005209 31.3 µM -0.955439103432446 0.226947990923845 no 2628 0.169677843589179 3984 3367314
SGTC_135 0933-0004 26.348 µM -0.95544937371085 0.226945354129684 no 2629 0.169675247830716 4025 21230617 YGL099W LSG1
SGTC_476 mead acid 10 µM -0.955534744015289 0.226923436802484 no 2630 0.169653671924339 4052 5312531 An omega 9 fatty acid.
SGTC_2128 5255449 168.493 µM -0.955819825098529 0.226850255888514 no 2631 0.169581635234322 4028 736008
SGTC_2022 5136654 200 µM -0.956180694304091 0.226757639099564 no 2632 0.169490475909369 4100 1713771
SGTC_590 k048-0076 22.4 µM -0.958756205912357 0.226097255988791 no 2633 0.168840788067996 4067 6832814
SGTC_2112 5488546 200 µM -0.959304596853141 0.225956784373215 no 2634 0.168702660144367 4013 600757
SGTC_3229 9132204 49.47 µM -0.959479917447473 0.225911886006143 no 2635 0.168658515969414 4092 17682924
SGTC_2050 5263056 171 µM -0.959800064816732 0.225829911541824 no 2636 0.168577924852708 4062 763468 YGL055W OLE1
SGTC_1299 1079-1439 3.74 µM -0.959979532492547 0.225783965793394 no 2637 0.168532758049866 3999 323161
SGTC_183 3914-0051 30.55 µM -0.960347881648469 0.225689680821006 no 2638 0.168440079636884 4082 1596232
SGTC_1322 1348-1070 12 µM -0.961597257149049 0.225370048752472 no 2639 0.168125974918557 4033 6758089
SGTC_1234 0326-0494 15.5 µM -0.96173457264766 0.225334934492007 no 2640 0.168091475516625 4134 1547813
SGTC_1046 2001-0062 216 µM -0.961974348630148 0.225273626509025 no 2641 0.168031244674666 3953 739778
SGTC_1746 st038117 42 µM -0.962337440882514 0.225180805949092 no 2642 0.16794006368541 4110 2898218
SGTC_3175 9106517 49.47 µM -0.963619891459905 0.224853134950522 no 2643 0.167618265194114 4067 41468073
SGTC_201 4262-0159 12.803 µM -0.964077226647983 0.224736349491354 no 2644 0.167503604644722 4078 1341029
SGTC_3100 9120536 49.47 µM -0.964528462201452 0.224621155360217 no 2645 0.167390522898736 3873 16421196
SGTC_1009 4106-0057 9.87 µM -0.965810098049985 0.224294154371574 no 2646 0.167069607305194 4034 2928005
SGTC_833 3852-0053 558 µM -0.966255829756831 0.224180492219257 no 2647 0.166958091220323 4122 3123681
SGTC_2779 methotrexate 400 µM -0.966387184712642 0.224147002779427 no 2648 0.16692523713552 4072 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_785 1270-0111 65.3 µM -0.968380827134348 0.223639065088716 no 2649 0.166427105606813 3986 6741994
SGTC_1229 0139-0193 12.2 µM -0.969000951528766 0.22348120414208 no 2650 0.166272357211752 4117 3090752
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.969886599604075 0.223255860546089 no 2651 0.166051510132408 4047 6857784
SGTC_1572 epiandrosterone 68.9 µM -0.971138910853732 0.22293744429992 no 2652 0.165739554778322 3965 441302 A steroid.
SGTC_1127 asiatic acid 681.4 nM -0.971912287637565 0.222740932580848 no 2653 0.165547093144161 4019 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_419 nsc-638432 893 µM -0.972561285718801 0.222576101163516 no 2654 0.165385695841855 4012 368090
SGTC_3067 9117431 49.47 µM -0.973001792534291 0.222464261631779 no 2655 0.165276205600816 4100 17150885
SGTC_2945 9067681 61.76 µM -0.973374206820239 0.22236973500316 no 2656 0.165183676709747 4122 16456930
SGTC_145 3737-0113 38.366 µM -0.975955680032098 0.221715132625107 no 2657 0.164543213868625 4016 6849351
SGTC_2937 9044753 11.33 µM -0.976944062551921 0.221464793258952 no 2658 0.164298423041765 4020 6465530 YGL099W LSG1
SGTC_2815 7968870 71.43 µM -0.977023548804563 0.221444667855547 no 2659 0.164278747095805 4050 2977326 YHR190W ERG9
SGTC_3003 9075612 71.4286 µM -0.977491143702356 0.221326297031529 no 2660 0.164163030064686 4084 6501993
SGTC_2765 myclobutanil 7.74 µM -0.9785464167697 0.221059289539673 no 2661 0.163902072986722 4100 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1676 st018489 23.4 µM -0.979363098434554 0.220852777556877 no 2662 0.163700301735356 4089 3696235
SGTC_1924 st058459 75.1 µM -0.981905326848129 0.220210639004299 no 2663 0.16307324562268 4042 688683
SGTC_1019 4262-0212 3.4 µM -0.982678380913009 0.220015586661025 no 2664 0.162882877095439 4086 4677213
SGTC_2795 7780010 54.55 µM -0.984820616302355 0.219475588961728 no 2665 0.162356096012463 4070 953673
SGTC_1031 k035-0009 16 µM -0.985335891919986 0.219345816057875 no 2666 0.162229554069204 4137 5180959
SGTC_2990 9074105 71.4286 µM -0.988570266526099 0.218532241906677 no 2667 0.161436719859707 3987 6502001
SGTC_2452 5863136 48.41 µM -0.99012737504184 0.218141187466907 no 2668 0.161055932242379 4036 2184096
SGTC_207 4185-0010 4.486 µM -0.992793553497803 0.217472536994009 no 2669 0.160405286075575 4132 3761753
SGTC_1652 st011932 78 µM -0.996394563673365 0.216571321053149 no 2670 0.159529236677636 4035 1551076
SGTC_942 3253-1115 227 µM -0.996426513912359 0.216563334627783 no 2671 0.159521477905072 4152 46497897
SGTC_2304 7443016 91.4 µM -0.997120989811728 0.216389782416762 no 2672 0.159352892922557 4006 939854
SGTC_1892 st058411 7.36 µM -0.997576363652406 0.216276026444445 no 2673 0.159242413643367 4105 3934738
SGTC_1079 idarubicin 2.36 µM -0.999432047372444 0.215812820188423 no 2674 0.158792720866508 4100 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1716 st033144 30.6155 µM -1.00101742532051 0.215417542115445 no 2675 0.158409192028003 4106 674617
SGTC_82 0054-0107 293.755 µM -1.00243728503689 0.215063889045911 no 2676 0.158066221000917 4036 3104697
SGTC_1304 1165-0502 251 µM -1.00287737663026 0.214954341238415 no 2677 0.157960014695796 4095 767425
SGTC_2652 actinonin 100 µM -1.00332222030622 0.214843643481388 no 2678 0.157852709207814 4098 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1236 0330-0013 258 µM -1.0086009780574 0.213532573856412 no 2679 0.15658301904197 4117 4617066
SGTC_2323 6148992 148.28 µM -1.01012450352386 0.213155049061382 no 2680 0.156217821940664 4075 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3028 9087778 49.47 µM -1.01140120422704 0.212838986679615 no 2681 0.155912222523995 4081 17217395
SGTC_2152 5568786 200 µM -1.01185360573721 0.212727055000987 no 2682 0.155804027373443 4081 5399883
SGTC_197 4544-0043 41.561 µM -1.01566393911612 0.211785679596268 no 2683 0.154894722870755 4093 896523
SGTC_344 k064-0035 6.43 µM -1.02110475590624 0.210445713429137 no 2684 0.153602405048229 4065 5088750
SGTC_576 1073-0113 22.7 µM -1.0227653286142 0.21003774037502 no 2685 0.153209407378176 4251 5439563
SGTC_1710 st031758 61.5 µM -1.02281126236915 0.210026461880709 no 2686 0.153198545993955 4142 5394341
SGTC_955 1216-0110 33 µM -1.02610877643998 0.20921772611862 no 2687 0.152420156934771 4100 3619719
SGTC_1373 2887-0003 58.5 µM -1.02621617386759 0.209191417096699 no 2688 0.152394849632424 4082 776948
SGTC_2522 biochanin a 4.94 µM -1.02848168606455 0.208636891257189 no 2689 0.151861650631494 4132 5280373 A possible chelator.
SGTC_1182 1222-0449 220 µM -1.03003001157714 0.208258409026128 no 2690 0.151497958766986 4116 658318
SGTC_610 4215-0184 155 µM -1.03060373959992 0.208118266339131 no 2691 0.151363340853968 4138 5605015
SGTC_1451 4152-0210 104 µM -1.03360699774884 0.207385578933471 no 2692 0.150659963324978 4162 659563
SGTC_588 3970-1144 52.9 µM -1.0345196383708 0.207163229790022 no 2693 0.150446650409125 4004 1888707
SGTC_1648 st011736 69.8 µM -1.03726059859441 0.206496290357786 no 2694 0.149807211616306 4125 2855514
SGTC_1101 ebselen 5.29 µM -1.03859872099355 0.206171156624433 no 2695 0.149495700445505 4176 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_589 1227-0070 34.1 µM -1.03887645575458 0.206103711359704 no 2696 0.149431098783406 4201 2841384
SGTC_164 4100-3994 89.624 µM -1.03919537907118 0.206026279981822 no 2697 0.149356939568453 4062 4615967
SGTC_723 4182-0001 115 µM -1.04056016138459 0.205695119476584 no 2698 0.149039864421586 4150 744821 YLR208W SEC13
SGTC_2537 larixol 68.93 µM -1.04267801823474 0.205181853556965 no 2699 0.148548720966103 4127 6708759
SGTC_2648 atorvastatin 78.68 µM -1.04673291319965 0.204201269418027 no 2700 0.147611389625809 4136 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_826 1683-5028 118 µM -1.04766839656618 0.203975440877136 no 2701 0.147395706519552 4192 722377
SGTC_1951 sophoraflavanone G 9.2 µM -1.04869096460581 0.203728760142109 no 2702 0.147160187051288 4106 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1520 flindersine 88 µM -1.05144410407369 0.20306548707018 no 2703 0.146527334315584 4233 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2081 5214970 32.255 µM -1.05206899719978 0.202915120565191 no 2704 0.146383947471023 4112 2063512
SGTC_2421 5690543 90.72 µM -1.05290338810628 0.202714446840042 no 2705 0.146192636565467 4159 3397993
SGTC_2306 7482397 179.52 µM -1.05495700724777 0.202221050150315 no 2706 0.145722493987571 4163 891448
SGTC_2161 5662504 8.5105 µM -1.05606118920735 0.201956059779888 no 2707 0.145470130167674 4116 2859334
SGTC_2457 5731572 11.68 µM -1.05831322376646 0.201416243309561 no 2708 0.144956333072019 4199 2865357
SGTC_529 4076-0302 30.3 µM -1.05934151489492 0.201170048042801 no 2709 0.144722137304734 4109 5816522
SGTC_2620 irigenin 100 µM -1.05950448260815 0.20113104659932 no 2710 0.14468504442521 4188 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3063 1327-0034 4 µM -1.05967355030238 0.201090590100738 no 2711 0.144646569904696 4041 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3285 9112818 20.8695 µM -1.05985323312129 0.20104759884112 no 2712 0.144605687268783 4121 17017947 YPR165W RHO1
SGTC_1772 st048439 82.2 µM -1.06273919838797 0.200357852838216 no 2713 0.14395011969452 4208 2927068 YDL195W SEC31
SGTC_1889 st059080 5.18 µM -1.0636539995371 0.200139512347234 no 2714 0.143742735168093 4119 176925 Isolated from Daphnopsis sellowiana.
SGTC_693 4161-2696 114 µM -1.06438062895636 0.199966185765592 no 2715 0.143578152718974 4188 805759
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.06501087729269 0.199815922567342 no 2716 0.143435503746855 4175 115019
SGTC_647 0140-0236 81 µM -1.0653136636007 0.19974375670756 no 2717 0.143367005822822 4175 990837
SGTC_1333 1482-0047 286 µM -1.06602257397269 0.199574856886289 no 2718 0.143206718767458 4178 3811116
SGTC_817 1391-0715 46 µM -1.06754752103307 0.199211825532607 no 2719 0.142862333399752 4155 1353946
SGTC_1132 3456-3614 2.5 µM -1.07051383375175 0.198506800649081 no 2720 0.142194042754775 4223 3125502
SGTC_3279 9140807 49.47 µM -1.07171236738724 0.198222364021674 no 2721 0.141924622092978 4201 45595718
SGTC_3241 9133421 49.47 µM -1.07188452834221 0.198181526911428 no 2722 0.141885950111908 4208 17018221
SGTC_1198 1612-1005 86.7 µM -1.0723019710527 0.198082529301342 no 2723 0.141792210878524 4234 6998509
SGTC_290 2043-6722 48.1 µM -1.07459985803188 0.197538114306476 no 2724 0.14127695772389 4194 773758 YLR208W SEC13
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.0808946701568 0.196051388427491 no 2725 0.13987198488227 4153 6708739 YPR165W RHO1
SGTC_1143 3454-2408 5.08 µM -1.08269885567049 0.195626525626478 no 2726 0.139471056063703 4166 X1143
SGTC_1744 st037937 38.9 µM -1.08366926802523 0.195398237202626 no 2727 0.139255733175571 4260 1016152
SGTC_1855 st056195 39.6 µM -1.09014507140417 0.193878958726208 no 2728 0.137824622470279 4131 4028379
SGTC_1886 st057356 49.9 µM -1.09275535309453 0.193268605951696 no 2729 0.137250614569861 4149 24207747
SGTC_1782 st039423 80.636 µM -1.09327900292022 0.193146304168414 no 2730 0.137135659496841 4224 2068169
SGTC_2947 9072639 7.68 µM -1.09351738343476 0.193090644519573 no 2731 0.137083350422563 4189 16488146
SGTC_2873 9040596 71.43 µM -1.0956249786339 0.192598966653311 no 2732 0.136621462934665 4174 6463863
SGTC_3276 9139060 49.47 µM -1.09741397702745 0.192182214804295 no 2733 0.136230233101187 4269 4870619
SGTC_544 k015-0020 52.4 µM -1.09835251872042 0.191963799860697 no 2734 0.136025293574981 4203 3008304
SGTC_2395 5646831 180.19 µM -1.10033138195267 0.19150378216301 no 2735 0.135593881824057 4220 6808628
SGTC_2930 9013230 14.89 µM -1.1007520111146 0.191406087446129 no 2736 0.135502301444622 4206 2995857
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.1008144622947 0.191391585230203 no 2737 0.135488708039838 4216 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.10091981681407 0.191367121662419 no 2738 0.135465778219183 4177 364106
SGTC_1307 1187-1599 12.2 µM -1.10165643742723 0.191196130164205 no 2739 0.135305531168691 4174 1538471
SGTC_318 1488-0629 67.2 µM -1.10332732734642 0.190808614398111 no 2740 0.134942521682851 4234 3662576
SGTC_1632 st005650 90 µM -1.10503799460161 0.1904123730647 no 2741 0.134571563033089 4225 2759605
SGTC_2251 lansoprazole 556 µM -1.10645762938918 0.190083927479198 no 2742 0.134264246797955 4116 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2197 6588183 93.1375 µM -1.11075104483583 0.189092726890229 no 2743 0.133337761950362 4153 884136
SGTC_281 1672-3440 14.9 µM -1.11138799163664 0.18894594961382 no 2744 0.133200689465779 4249 6833000
SGTC_7 0192-1582 4.227 µM -1.11237162887788 0.18871941933649 no 2745 0.132989198921013 4243 252616
SGTC_1554 st069299 38.7 µM -1.11462150889859 0.188201904824134 no 2746 0.132506324615585 4176 24207999
SGTC_1370 2001-0092 44.6 µM -1.11475659331757 0.188170860772301 no 2747 0.132477370987013 4254 790957
SGTC_547 1120-0019 610 nM -1.11600816560615 0.187883384444185 no 2748 0.13220931967437 4159 3676939
SGTC_307 1501-1223 22.3 µM -1.11758283835552 0.187522079958098 no 2749 0.1318726008789 4246 2830329
SGTC_2837 9008476 45.46 µM -1.1190996848253 0.187174449857689 no 2750 0.131548807151282 4226 2992805
SGTC_2273 7815444 169.05 µM -1.12021796734309 0.186918417834066 no 2751 0.131310444595624 4177 2824616
SGTC_382 3229-0966 23.2 µM -1.12150184442123 0.186624740111788 no 2752 0.131037153430371 4246 5722370
SGTC_2124 5246320 200 µM -1.12198513991687 0.18651426376858 no 2753 0.130934379112362 4228 579342
SGTC_2217 6934799 96.0675 µM -1.1233454889851 0.18620351957119 no 2754 0.130645395669207 4187 675606
SGTC_3200 9114385 49.47 µM -1.12455893356364 0.185926603638995 no 2755 0.130387992000063 4232 17018030 YLR208W SEC13
SGTC_621 3584-0052 32.1 µM -1.12470065377669 0.18589427882827 no 2756 0.130357952290336 4233 2273927
SGTC_2927 9011802 47.9 µM -1.12516867655191 0.185787552778862 no 2757 0.130258781905625 4228 43912568
SGTC_2919 7978188 46.38 µM -1.12544154920322 0.185725345529199 no 2758 0.130200986408008 4221 2980291
SGTC_2892 9047358 58.44 µM -1.1255257194694 0.185706159696089 no 2759 0.130183162396901 4231 6466771
SGTC_1736 st036774 51 µM -1.1257904190934 0.185645831880634 no 2760 0.130127120245462 4264 1272247
SGTC_1620 st003704 16.5 µM -1.13130783217753 0.184391125203003 no 2761 0.128962774478754 4208 2834414
SGTC_2385 9074692 200 µM -1.13448863317449 0.183670187198441 no 2762 0.128294819540616 4248 17046906
SGTC_934 2950-0684 338 µM -1.13531452274559 0.183483284466817 no 2763 0.128121779718688 4264 1121253
SGTC_1859 st055998 20 µM -1.13793068211939 0.182892018111541 no 2764 0.127574714123509 4193 676301
SGTC_1660 st012960 28.1 µM -1.13900466332124 0.182649637139073 no 2765 0.127350604587563 4253 24207266
SGTC_773 4358-1457 44.6 µM -1.13902307478073 0.182645483706491 no 2766 0.12734676502502 4240 1186886
SGTC_1669 st015249 58.4 µM -1.14011531067953 0.182399192252989 no 2767 0.127119132028732 4316 722793
SGTC_20 0481-0013 4.944 µM -1.14042272721648 0.182329909438474 no 2768 0.127055114407575 4267 182045
SGTC_2752 diclazuril 33.15 µM -1.14097864878942 0.182204662523249 no 2769 0.126939404105755 4183 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2268 7933382 153.85 µM -1.14105609951193 0.182187217452751 no 2770 0.126923289226244 4259 935025 YOR257W CDC31
SGTC_1501 4491-0275 38.4 µM -1.14117130536141 0.182161270314903 no 2771 0.126899321414575 4205 5104718
SGTC_3329 9141233 27.5565 µM -1.14468385746483 0.181371267916697 no 2772 0.126170070368413 4197 4909101 YNL103W MET4
SGTC_1360 1598-0022 39.8 µM -1.1447641997943 0.181353223383569 no 2773 0.126153424508367 4272 761525
SGTC_3267 9137951 49.47 µM -1.14661957190154 0.180936827738145 no 2774 0.125769441956078 4263 16643986
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.14838717400861 0.180540687834375 no 2775 0.125404383067964 4136 6708630 An antioxidant.
SGTC_1752 st044819 83.042 µM -1.14863123396941 0.180486033969602 no 2776 0.125354036084409 4220 441209 YML126C ERG13
SGTC_759 3486-0358 89.3 µM -1.15046243292171 0.180076293328384 no 2777 0.124976729247634 4239 875103
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.15475860633894 0.179117295833717 no 2778 0.124094646193758 4308 165506
SGTC_366 0181-0206 4.31 µM -1.1568074347136 0.178661087210688 no 2779 0.12367552181839 4268 274874
SGTC_416 estradiol valerate 100 µM -1.15728216140401 0.178555485239801 no 2780 0.123578549613741 4270 13791 A steroid.
SGTC_528 3492-0019 172 µM -1.15830024020648 0.178329148302279 no 2781 0.123370766699658 4243 2869262
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.15907252715647 0.178157575881979 no 2782 0.123213311560762 4197 279621
SGTC_2237 6667747 47.222 µM -1.15996110165413 0.177960297625529 no 2783 0.123032321820266 4257 729940 YDL015C TSC13
SGTC_3169 9102970 49.47 µM -1.16098226105747 0.177733753515022 no 2784 0.122824556712718 4310 17027839
SGTC_2992 9074591 71.4286 µM -1.16121112077198 0.177683005979314 no 2785 0.122778026682272 4213 17741321
SGTC_2356 9061756 188.97 µM -1.16229810850185 0.177442101302643 no 2786 0.122557197341239 4284 20104043
SGTC_1896 st058441 89 µM -1.163084741815 0.177267891618399 no 2787 0.122397561055934 4254 688759
SGTC_1814 st052110 31.539 µM -1.16366669207826 0.177139081064031 no 2788 0.122279556300003 4192 674163
SGTC_2722 naftopidil 47.16 µM -1.16431976246318 0.176994598999824 no 2789 0.122147225312258 4197 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_543 3844-1095 191 µM -1.16570018315536 0.17668944667302 no 2790 0.121867843050502 4262 4230703
SGTC_2208 7283366 200 µM -1.16981045651099 0.17578281124156 no 2791 0.121038627366961 4238 898663
SGTC_2564 betulinic acid 100 µM -1.17200795977866 0.175299301730404 no 2792 0.120596930214795 4317 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3326 9140064 16.379 µM -1.174182554205 0.174821663773741 no 2793 0.120160956150766 4187 1868434
SGTC_860 0443-0016 25.1 µM -1.1772914027053 0.174140258000393 no 2794 0.119539608605876 4290 5337942
SGTC_324 1315-0088 19.6 µM -1.18060612225135 0.173415591020396 no 2795 0.118879615195577 4229 6787421
SGTC_1877 wortmannin 25 µM -1.18158743200941 0.173201424988438 no 2796 0.11868472138456 4274 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2007 4011539 71.82 µM -1.18254109568402 0.172993454036203 no 2797 0.118495534641293 4209 45595301
SGTC_2292 7671323 168.05 µM -1.18400532431503 0.172674451033973 no 2798 0.118205477596782 4320 937504
SGTC_1794 st048918 76.9 µM -1.18449024569527 0.172568886742002 no 2799 0.118109527633691 4195 672303
SGTC_725 1497-0963 19 µM -1.18451174858761 0.172564206652531 no 2800 0.118105274195617 4381 3549977
SGTC_650 1328-0195 38 µM -1.18648918727657 0.172134164482984 no 2801 0.117714584531099 4270 2780821
SGTC_3102 9121669 49.47 µM -1.19108639310711 0.171137036258371 no 2802 0.116809835496514 4316 41905072
SGTC_1366 1683-0113 21.9 µM -1.19175076749679 0.170993240377918 no 2803 0.116679492659332 4272 708623
SGTC_2435 5706476 10.6 µM -1.19357796537285 0.170598164011462 no 2804 0.116321548771169 4268 5725375
SGTC_285 1486-1325 46 µM -1.19379642291104 0.170550968308519 no 2805 0.116278805637297 4331 22310230
SGTC_3097 9117246 49.47 µM -1.19584418272026 0.170108975524902 no 2806 0.115878685253178 4294 16423892
SGTC_1460 k062-0059 9.15 µM -1.19760370976399 0.169729782408575 no 2807 0.115535665598583 4162 1373085
SGTC_1830 st055982 50.3 µM -1.19930858851055 0.169362884001548 no 2808 0.115203988394286 4250 455313 An antimicrobial agent.
SGTC_3281 9140613 49.47 µM -1.20160949461899 0.168868525266217 no 2809 0.114757430571887 4287 16013766
SGTC_2525 harmine 47.85 µM -1.20623109910582 0.167878359669881 no 2810 0.11386419795028 4272 5280953 A monoamine oxidase inhibitor
SGTC_1983 st071813 46.9 µM -1.20719013193797 0.16767335882759 no 2811 0.113679464950237 4354 11838595
SGTC_351 caspofungin 25 nM -1.21149580363118 0.166754975226021 no 2812 0.11285272098853 4290 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3227 9130768 49.47 µM -1.21263359514857 0.166512831738867 no 2813 0.112634969277962 4352 17720899
SGTC_2374 9071832 200 µM -1.21629355675557 0.165735463137597 no 2814 0.111936557562108 4224 17381698
SGTC_1709 st033179 39.1045 µM -1.21741592885561 0.165497544387755 no 2815 0.111723002771433 4292 573381
SGTC_3280 9140961 49.47 µM -1.21742750684881 0.165495091253974 no 2816 0.111720801335584 4341 4901226
SGTC_2600 tangeritin 87.95 µM -1.22001970337366 0.164946451385364 no 2817 0.111228702853053 4219 68077 A bioactive flavone.
SGTC_844 0330-0132 15.3 µM -1.22057635105566 0.164828790377903 no 2818 0.111123232452774 4339 2828079
SGTC_605 1315-0399 119 µM -1.22258194860929 0.164405309540065 no 2819 0.110743817272974 4367 24020461
SGTC_2568 diosmetin 100 µM -1.22325243033719 0.164263895134375 no 2820 0.110617184075227 4348 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2425 5628681 7.85 µM -1.22592217682232 0.163701589121842 no 2821 0.11011398121944 4372 5714958
SGTC_3112 9123419 49.47 µM -1.22655904976214 0.163567634803894 no 2822 0.109994184221838 4361 17015854
SGTC_457 grayanotoxin iii 135 µM -1.22689815864617 0.163496338636224 no 2823 0.109930435369415 4153 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1689 st020265 53.493 µM -1.2291921282668 0.163014571642834 no 2824 0.1094998897892 4321 5758320 YPR016C TIF6
SGTC_2387 9077560 195.08 µM -1.23053673442166 0.162732614210595 no 2825 0.109248089902121 4320 5303272
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.23071047360346 0.162696205096155 no 2826 0.109215584722176 4330 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1507 4075-3230 155 µM -1.23142707842926 0.162546088025842 no 2827 0.109081587261267 4252 659771
SGTC_2880 9042983 58.44 µM -1.23292689571119 0.162232192467841 no 2828 0.108801519936668 4276 6464714
SGTC_1570 verbenone 133 µM -1.23451938248978 0.161899334465545 no 2829 0.108504714385328 4332 29025 A natural terpanoid with antifungal properties.
SGTC_3026 9090633 49.47 µM -1.23487397249957 0.161825279467678 no 2830 0.10843870573844 4314 25236842
SGTC_2489 cantharidin 73.42 µM -1.23491680682611 0.161816335148981 no 2831 0.108430733877502 4264 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_480 am 92016 50 µM -1.2368154101215 0.161420207704437 no 2832 0.108077809850044 4325 2129 K+ channel blocker.
SGTC_881 0833-0569 170 µM -1.23877937443782 0.16101110920839 no 2833 0.107713607113898 4337 5418700
SGTC_2970 9090938 41.86 µM -1.23879146744223 0.161008592304375 no 2834 0.107711367297394 4389 17217104
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.24434296361708 0.159855877042928 no 2835 0.106686682491067 4343 5106787 A p450 inhibitor.
SGTC_99 0109-0120 622.8 µM -1.24466384575743 0.15978941436596 no 2836 0.106627670480112 4303 759414
SGTC_362 0310-0100 9.03 µM -1.24615786060541 0.159480204777259 no 2837 0.106353223051562 4378 790235
SGTC_2650 prasterone 100 µM -1.25047618871554 0.158588663433732 no 2838 0.105562824117089 4315 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_410 α-linolenic acid 100 µM -1.25060546308581 0.158562024548561 no 2839 0.105539228232016 4355 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1390 3413-2614 145 µM -1.25195006134509 0.158285124304593 no 2840 0.105294030722824 4343 3421432
SGTC_1147 3809-1045 12.3 µM -1.25416553625927 0.157829572325929 no 2841 0.104890921831383 4312 325925
SGTC_1446 4239-0190 62 µM -1.25679553846935 0.15728990300933 no 2842 0.104413841012325 4351 1340085
SGTC_249 wiskostatin 11.211 µM -1.25826573225558 0.156988752492701 no 2843 0.104147834878457 4319 2775510 A n-wasp and actin depolymerizer.
SGTC_2276 7947513 42.08 µM -1.25879529577904 0.156880371111054 no 2844 0.10405213997201 4277 2105100
SGTC_1982 st072467 71.9 µM -1.25965612722454 0.15670429694991 no 2845 0.103896719291559 4310 3163533
SGTC_1878 temozolomide 1 mM -1.2606976581356 0.156491436539045 no 2846 0.103708899014486 4268 5394 DNA alkylating agent.
SGTC_1243 0416-0003 5.65 µM -1.2646512261233 0.155685169228611 no 2847 0.102998190614783 4335 2141977
SGTC_663 1486-0733 13.9 µM -1.26483351511427 0.155648060475061 no 2848 0.102965507187915 4354 722445 YPR165W RHO1
SGTC_1055 3448-0672 86 µM -1.26570467296903 0.155470798556864 no 2849 0.102809417347747 4311 748378
SGTC_438 sphingosine 6.67 µM -1.2702685755535 0.154544319851349 no 2850 0.101994488895236 4263 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2206 7254556 146.969 µM -1.27273187786554 0.154045785421646 no 2851 0.101556600820131 4377 4398905
SGTC_686 1319-0111 510 µM -1.27386510127577 0.153816796188452 no 2852 0.101355614186897 4378 4562600
SGTC_153 4077-0274 519.67 µM -1.27490841987312 0.153606173225006 no 2853 0.101170829266157 4395 3121976
SGTC_2703 st077852 53.4 µM -1.27720551234227 0.153143114442732 no 2854 0.100764850696979 4378 6281836
SGTC_3345 9148410 3.559 µM -1.28079031904775 0.152422322449218 no 2855 0.100133662665967 4289 4903596
SGTC_779 1360-0071 233 µM -1.28169037499158 0.152241703674403 no 2856 0.0999756413403393 4390 7566
SGTC_2160 5660466 132.927 µM -1.28191077621207 0.152197496314933 no 2857 0.0999369736365141 4283 2859134
SGTC_332 4112-0506 40.9 µM -1.28343445364869 0.151892115204468 no 2858 0.0996699548362892 4321 2790355
SGTC_2720 fluspirilene 36.88 µM -1.28618313612654 0.151342244259902 no 2859 0.0991895775401166 4343 3396 An atypical antipsychotic.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.28800089674733 0.150979331366521 no 2860 0.0988728255119787 4349 5379071
SGTC_169 k015-0017 16.025 µM -1.29036331777877 0.150508544094292 no 2861 0.0984622710465258 4347 1840002
SGTC_1081 sertraline 6 µM -1.29110555325622 0.150360832248579 no 2862 0.0983335393536151 4339 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.29259767529242 0.150064178287632 no 2863 0.0980751220321199 4411 368090
SGTC_2096 5468907 200 µM -1.29509759932121 0.149568034806177 no 2864 0.0976432814877098 4352 759785
SGTC_2 0422-0095 29 µM -1.29770340503225 0.149052044147026 no 2865 0.0971946365775988 4258 6790840
SGTC_1123 mangostin 811.285 nM -1.30061603953643 0.148476705498679 no 2866 0.0966949570258704 4359 5281650 An antioxidant.
SGTC_1204 4049-0315 18.3 µM -1.30154027274057 0.14829445062975 no 2867 0.0965367944077257 4401 588402
SGTC_43 0570-0105 72.5 µM -1.30230809230605 0.148143153723043 no 2868 0.0964055432187745 4344 1114046 YDL195W SEC31
SGTC_2732 terfenadine 20 µM -1.30277286034263 0.14805162255607 no 2869 0.0963261594390417 4442 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_887 0885-0007 9.62 µM -1.305976477672 0.147421733621652 no 2870 0.0957802784441375 4403 5719458
SGTC_806 3966-4455 5.86 µM -1.3067003725381 0.14727965192715 no 2871 0.0956572460594276 4342 714982
SGTC_1516 st013856 110 µM -1.31162268774011 0.146315964114745 no 2872 0.0948237370595446 4405 5281404 A mutagen and neurotoxin.
SGTC_420 mitomycin C 81.9 mM -1.31183596764975 0.146274304230984 no 2873 0.0947877431413064 4356 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1174 0739-0097 51.1 µM -1.31419022517977 0.145814977257676 no 2874 0.0943910985589387 4419 728447
SGTC_3259 9138485 49.47 µM -1.3184620593663 0.144983999715029 no 2875 0.0936745089291379 4389 17646153
SGTC_1351 1496-0003 46.5 µM -1.31864492276932 0.144948499549503 no 2876 0.0936439239424954 4391 3891978
SGTC_1466 k213-0079 57.5 µM -1.31885459329114 0.144907802389268 no 2877 0.093608864381393 4327 3657981
SGTC_1394 3474-0001 65.7 µM -1.31984845909226 0.144714997175474 no 2878 0.093442809314594 4348 5017666 YIL048W NEO1
SGTC_548 1436-0017 110 µM -1.32006425625186 0.144673156399513 no 2879 0.0934067826997792 4416 9677137
SGTC_949 1165-0505 146 µM -1.32086270212859 0.144518417083948 no 2880 0.093273574039809 4366 6244267
SGTC_1142 3253-1408 9.78 µM -1.3219095991308 0.144315696801323 no 2881 0.0930991277929679 4394 256655
SGTC_2666 tannic acid 100 µM -1.32252143695818 0.144197309805868 no 2882 0.0929972879105325 4362 16134267 A thiamine antagonist.
SGTC_3247 9135149 49.47 µM -1.32301667543068 0.144101532054656 no 2883 0.0929149162134727 4427 8934436 YOR116C RPO31
SGTC_2043 5101342 149 µM -1.32491487351231 0.143734823172117 no 2884 0.0925996935583116 4404 678451
SGTC_574 1315-0397 40 µM -1.32807850622678 0.14312504803417 no 2885 0.0920760866179994 4363 6794277
SGTC_2465 5809242 33.21 µM -1.3285672147217 0.143031007859209 no 2886 0.0919953972474983 4440 2731748
SGTC_2850 9015429 58.44 µM -1.32864792265954 0.143015481578652 no 2887 0.091982076811942 4377 6457570
SGTC_3311 9131146 2.8755 µM -1.32927265764251 0.142895336007404 no 2888 0.0918790157872607 4334 4900406 YPR165W RHO1
SGTC_175 3793-3120 23.7 µM -1.33055016716249 0.142649864870799 no 2889 0.0916685344246076 4383 5322297
SGTC_128 0906-2981 13.371 µM -1.33194123789578 0.142382897594235 no 2890 0.0914397493531823 4370 6740226
SGTC_2684 capsaicin 100 µM -1.33385102873549 0.142016931035446 no 2891 0.0911263417654165 4421 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_875 0709-0210 25.7 µM -1.33484021986408 0.14182762633327 no 2892 0.0909643233598455 4371 6251364
SGTC_266 formosanin C 406 nM -1.33573860492797 0.141655847617222 no 2893 0.0908173632242236 4229 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2781 5567276 71.43 µM -1.33657938075266 0.141495211990469 no 2894 0.0906799866146563 4400 2853274
SGTC_3120 9124077 49.47 µM -1.33736980457432 0.141344309045785 no 2895 0.0905509778633948 4517 18774327 YGL155W CDC43
SGTC_1650 st011916 45.8 µM -1.33759189696327 0.141301928145921 no 2896 0.0905147536629122 4335 242528
SGTC_1766 st045414 44.774 µM -1.3378819310806 0.141246595200109 no 2897 0.0904674640814572 4400 253960
SGTC_836 0330-0104 1.35 µM -1.3423213601315 0.140401470445811 no 2898 0.0897459102650145 4411 46494820
SGTC_2923 7992654 58.14 µM -1.34248649112738 0.140370101178189 no 2899 0.0897191537929274 4388 2985126
SGTC_2872 9044037 25.97 µM -1.34264906230455 0.140339222838451 no 2900 0.0896928178865555 4442 6465195
SGTC_497 capsazepine 133 µM -1.34313002557389 0.140247896957742 no 2901 0.0896149373387076 4350 2733484 A calcium channel blocker.
SGTC_658 3253-0951 102 µM -1.34344657463443 0.140187812274195 no 2902 0.0895637072012683 4400 1184878
SGTC_1673 st016611 27.3 µM -1.34390787637624 0.140100283164277 no 2903 0.0894890893630227 4396 5226799
SGTC_2689 tacrolimus 100 µM -1.34516624090545 0.13986170520841 no 2904 0.089285777772038 4397 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.34719598069869 0.139477461617821 no 2905 0.0889585610539493 4402 616764
SGTC_1702 st027038 51 µM -1.3493298074912 0.139074288525029 no 2906 0.0886155277738214 4425 5521182
SGTC_1410 3909-8106 77.9 µM -1.35028470174208 0.138894124470656 no 2907 0.0884623387991217 4448 1039210
SGTC_475 α-linolenic acid 10 µM -1.35117273778088 0.138726717527289 no 2908 0.0883200527042824 4407 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.3544304396846 0.138113773308567 no 2909 0.0877995458519495 4371 2333 A French combination drug.
SGTC_3286 9117135 37.221 µM -1.3573564712018 0.137564810189754 no 2910 0.0873339860356033 4367 3438150
SGTC_2492 derrusnin 100 µM -1.35887257036108 0.137280956051544 no 2911 0.0870934860584735 4443 1715307 Part of coumarin class of compounds.
SGTC_746 1095-0025 46.6 µM -1.35988618232062 0.137091404172455 no 2912 0.0869329721193858 4417 6749286
SGTC_1565 sinapyl alcohol 95.1 µM -1.36013931632542 0.137044094421911 no 2913 0.0868929207389139 4414 5280507 A phenol propionate derived from cinnamic acid.
SGTC_348 k064-0012 10.7 µM -1.36065825177132 0.136947142305747 no 2914 0.0868108568116545 4348 5066323
SGTC_3186 9110464 49.47 µM -1.364523667452 0.136226446112612 no 2915 0.0862014052681451 4397 17018021
SGTC_3057 9095946 49.47 µM -1.36794111957803 0.135591436799964 no 2916 0.0856652536600626 4470 24540043
SGTC_1385 3091-4834 14.1 µM -1.36886207560738 0.135420658032791 no 2917 0.0855211961890348 4402 4072814
SGTC_966 1300-0360 30.2 µM -1.37163281738534 0.134907750816735 no 2918 0.0850888861263876 4411 70588
SGTC_2955 9076254 12.21 µM -1.37393921919266 0.134481817691482 no 2919 0.0847302763344618 4333 16459619
SGTC_3304 9125678 46.087 µM -1.37635774836365 0.134036170121722 no 2920 0.0843554511053863 4358 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1926 methyl fluorone black 53.6 µM -1.37722622113203 0.133876389840293 no 2921 0.084221158688127 4057 72721 Reacts with homocysteine.
SGTC_1530 rhein 70.4 µM -1.37777525742819 0.13377544655295 no 2922 0.0841363437327979 4492 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2299 7976368 114.88 µM -1.37832940184393 0.133673617175408 no 2923 0.0840508047083852 4437 2979718
SGTC_1923 st058458 19.1 µM -1.3796347387645 0.133433959599845 no 2924 0.0838495679295704 4424 3534982
SGTC_676 falcarinol 140 µM -1.38050169976885 0.133274950503978 no 2925 0.0837161133291426 4447 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1024 4507-0395 26 µM -1.38496187163567 0.132458972534015 no 2926 0.0830320631976948 4477 4201836
SGTC_514 4466-0038 2.65 nM -1.38706853545709 0.132074762804704 no 2927 0.0827104326843011 4220 5722064
SGTC_27 0485-0001 32.618 µM -1.38787509532085 0.131927867436055 no 2928 0.0825875413389258 4424 2054479
SGTC_1405 3909-7894 12 µM -1.39103160442594 0.131354069365615 no 2929 0.0821079216238003 4413 7104060
SGTC_2137 5261020 140 µM -1.39763863206298 0.130158612045659 no 2930 0.0811108056079465 4412 763655
SGTC_628 1636-0253 16 µM -1.40018347049976 0.129700170642786 no 2931 0.0807291921887032 4424 4456143
SGTC_12 0849-0099 9.267 µM -1.40108485156827 0.129538059348957 no 2932 0.080594350477548 4374 6071388
SGTC_2322 7413319 38.22 µM -1.40144856925475 0.129472685332497 no 2933 0.0805399884843425 4397 1840400
SGTC_1075 aripiprazole 15.2 µM -1.40208337779379 0.129358640666427 no 2934 0.080445175060512 4490 60795 An atypical antipschotic. YIL048W NEO1
SGTC_737 1950-0117 57.9 µM -1.40395485355958 0.129022831395976 no 2935 0.0801661468563685 4435 5393513
SGTC_923 1900-2434 73.3 µM -1.40547679204242 0.12875018759128 no 2936 0.0799397728768475 4412 5910570
SGTC_2697 mebhydrolin 72.4 µM -1.40779629225228 0.128335435864524 no 2937 0.0795956993002399 4472 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2259 7964009 200 µM -1.40781908655599 0.128331364604614 no 2938 0.0795923235726311 4460 313134
SGTC_2141 5621638 7.665 µM -1.40840641668987 0.128226493281853 no 2939 0.0795053801327717 4463 2856238
SGTC_703 3875-0075 71.8 µM -1.41023747356212 0.127899929129386 no 2940 0.0792347870813469 4482 2850814
SGTC_513 4245-1575 41.7 µM -1.41122608843575 0.127723852721973 no 2941 0.0790889800165116 4278 719745
SGTC_2155 5570423 76 µM -1.41131708402243 0.127707654502626 no 2942 0.0790755696405954 4418 797402
SGTC_3244 9134489 49.47 µM -1.41202304420987 0.127582034304994 no 2943 0.0789715880212318 4458 16584271
SGTC_635 k038-0028 24.7 µM -1.41236239478559 0.127521680058226 no 2944 0.0789216415901498 4437 4035102
SGTC_3220 9131269 49.47 µM -1.41291996887557 0.127422557391972 no 2945 0.0788396284634039 4442 17722206
SGTC_2799 7812892 81.82 µM -1.41428010480176 0.127180984215495 no 2946 0.0786398380406029 4465 20205235
SGTC_1679 SEC14.276 6.7 µM -1.41464510298541 0.127116211304256 no 2947 0.078586288799732 4422 1005053 YMR079W SEC14
SGTC_2618 avocadyne 43.43 µM -1.41857359516356 0.126420510454157 no 2948 0.0780116842573447 4370 3015189
SGTC_747 3448-8087 38.7 µM -1.42011433221327 0.126148385267003 no 2949 0.0777871992083332 4495 5168703
SGTC_1604 st002052 72.4 µM -1.42436697725096 0.125399402315646 no 2950 0.0771701341707973 4497 6254834 YHR062C RPP1
SGTC_1751 st044839 27.194 µM -1.42516091302896 0.125259917577331 no 2951 0.0770553460595436 4496 5291326
SGTC_2665 lovastatin 100 µM -1.4257137779665 0.125162850021251 no 2952 0.0769754889104065 4476 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1098 clofazimine 15.1 µM -1.4259947157836 0.125113545363449 no 2953 0.0769349336841336 4506 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1388 3346-4487 254 µM -1.42794752127759 0.124771202331079 no 2954 0.0766534820333001 4525 3345614
SGTC_2698 st077697 67.5 µM -1.42861354343427 0.124654592952905 no 2955 0.0765576696647447 4427 3154499
SGTC_1800 st050079 29.0735 µM -1.42884547974692 0.1246140026585 no 2956 0.0765243252501455 4270 3645560
SGTC_2484 5809818 12.04 µM -1.43092495675449 0.124250494001354 no 2957 0.0762258617974739 4436 2870548
SGTC_963 1269-2853 151 µM -1.43321304920915 0.12385137554325 no 2958 0.075898480793776 4441 3668223
SGTC_772 k072-0172 35.3 µM -1.43670413739358 0.123244145799862 no 2959 0.0754010394291133 4496 5861980
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.43677602269615 0.123231664238882 no 2960 0.075390822743101 4471 2374 Ca(2+)-ATPase inhibitor.
SGTC_1175 0741-0056 27.6 µM -1.43782551588607 0.12304953990935 no 2961 0.0752417838327178 4527 765927
SGTC_76 0433-0009 400.328 µM -1.44036989298877 0.122608783608889 no 2962 0.0748813884190789 4517 2841569
SGTC_1930 st074634 34.3 µM -1.4449099777288 0.121825069562451 no 2963 0.0742415866708905 4382 684253 YOR116C RPO31
SGTC_699 0375-0592 111 µM -1.44524619108236 0.121767172352464 no 2964 0.0741943730666646 4543 762578
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.44754598827867 0.121371656976877 no 2965 0.0738720329967959 4461 1377
SGTC_1180 1193-0155 285 µM -1.44986912868336 0.120973045036978 no 2966 0.0735475088028671 4508 2921347
SGTC_158 k038-0087 26.446 µM -1.45182432297627 0.12063828104523 no 2967 0.0732752295017177 4379 X158
SGTC_1280 0880-0253 10.1 µM -1.45185033016772 0.12063383255189 no 2968 0.0732716129581673 4447 6836607
SGTC_287 k060-0039 29.6 µM -1.45817839501735 0.119554856873627 no 2969 0.072395688641768 4500 5861974
SGTC_3256 9138902 49.47 µM -1.45894288253924 0.119424969193176 no 2970 0.0722904145202827 4579 17228773
SGTC_1420 4'-methoxyflavone 42 µM -1.46168276754025 0.118960276231311 no 2971 0.0719140808105655 4470 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1816 st051957 91.6 µM -1.46291742357023 0.118751292622982 no 2972 0.0717449878804046 4480 674121
SGTC_2733 amorolfine 100 µM -1.46406460391034 0.118557348118755 no 2973 0.0715881487099693 4635 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1647 st011722 22.4 µM -1.46996918628044 0.117562649229007 no 2974 0.070785049820363 4453 2854783
SGTC_1774 st048371 48.465 µM -1.47062099967775 0.11745320649135 no 2975 0.0706968207964975 4478 4242727
SGTC_3161 9100388 49.47 µM -1.48332580611786 0.115334399311443 no 2976 0.0689939345937191 4556 25236368
SGTC_1979 st071809 45.3 µM -1.48332934746228 0.115333812526212 no 2977 0.0689934643774059 4527 4976333
SGTC_1347 1493-0251 600 nM -1.4847449469131 0.115099423832869 no 2978 0.0688057001998773 4523 3986378
SGTC_3196 9111891 49.47 µM -1.48569533714306 0.114942252574583 no 2979 0.068679862277867 4477 18891510
SGTC_846 0335-0850 148 µM -1.4911534984134 0.114042561951703 no 2980 0.0679605996206166 4470 6819598
SGTC_904 1141-0088 396 µM -1.49390183425518 0.113591446586085 no 2981 0.0676006394835991 4496 1378119
SGTC_1497 4476-2978 41.3 µM -1.49453395582377 0.113487869549816 no 2982 0.0675180568295215 4522 1528379
SGTC_1396 3511-0007 98.6 µM -1.49520980848256 0.113377201421008 no 2983 0.0674298472463211 4514 X1396
SGTC_1423 4048-0112 5.59 µM -1.49655962110278 0.113156405506823 no 2984 0.0672539417175209 4541 X1423
SGTC_2724 maprotiline 69.64 µM -1.49782100878877 0.112950351192048 no 2985 0.0670898804629567 4435 4011 A tricyclic antidepressant.
SGTC_3074 9116018 49.47 µM -1.50177092270555 0.112306844777819 no 2986 0.0665781401096351 4543 17027303
SGTC_729 4092-0585 94.1 µM -1.50335913758582 0.11204883814462 no 2987 0.0663732289102097 4503 2169061
SGTC_1897 st060201 15 µM -1.50381898265198 0.111974215156691 no 2988 0.0663139910382078 4499 611878
SGTC_473 2-arachidonoylglycerol 10 µM -1.50417705814508 0.111916131800261 no 2989 0.0662678916218484 4340 5282280 An endocannabinoid.
SGTC_2481 5478948 45.16 µM -1.5075006006215 0.111378048452117 no 2990 0.0658411950038686 4496 77792
SGTC_3337 9144342 33.5465 µM -1.50871469079833 0.111181949099724 no 2991 0.0656858548180573 4488 17682949
SGTC_280 3448-3607 3.04 µM -1.50972310597337 0.111019258331056 no 2992 0.0655570464316843 4466 626179
SGTC_2544 sphondin 68.51 µM -1.51359287473496 0.110396519200055 no 2993 0.0650645647026744 4462 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2270 7924575 90.91 µM -1.51777650337069 0.10972609437611 no 2994 0.0645353751881657 4474 1262135
SGTC_1207 2099-0101 141 µM -1.51992944835065 0.109382227061907 no 2995 0.0642643541417155 4507 5837381
SGTC_312 4092-0653 6.84 µM -1.52028799665284 0.109325035175709 no 2996 0.064219304744897 4397 1148278
SGTC_1522 st012842 45.6 µM -1.5253397597502 0.108521513216284 no 2997 0.0635871878072133 4347 3491067 YOR116C RPO31
SGTC_2671 danthron 100 µM -1.52569146574338 0.108465730266265 no 2998 0.0635433604546068 4505 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2865 9030313 51.95 µM -1.52819524986694 0.10806920928205 no 2999 0.0632320339170016 4495 42562754
SGTC_2219 9098279 200 µM -1.53248386336299 0.107392453934145 no 3000 0.0627015383078563 4445 902349
SGTC_1749 st037932 54.2 µM -1.53378885875143 0.107187129470551 no 3001 0.0625408023833626 4512 594497
SGTC_1937 st074714 47.2 µM -1.53544416769696 0.106927095063935 no 3002 0.062337380789073 4451 17250970
SGTC_2164 5685496 200 µM -1.53796808494847 0.106531486431294 no 3003 0.0620282092061634 4453 759046
SGTC_3353 9151644 39.2805 µM -1.54140850216415 0.105993925437812 no 3004 0.0616086980377278 4517 4909158
SGTC_2157 5649910 96.377 µM -1.54464372324493 0.105490216861871 no 3005 0.0612162320721096 4512 2858091
SGTC_3106 9121286 49.47 µM -1.54915039554775 0.104791438223305 no 3006 0.0606727853355763 4463 15943471
SGTC_256 clotrimazole 625 nM -1.55596411997421 0.103741315957225 no 3007 0.0598583122926425 4469 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1035 k081-0041 55.2 µM -1.55637047038391 0.1036789318577 no 3008 0.0598100114495067 4538 731709
SGTC_722 3534-0461 190 µM -1.55678995785281 0.103614559475641 no 3009 0.0597601811038158 4549 658262
SGTC_1821 st053465 65.6 µM -1.5600837544121 0.103110118121015 no 3010 0.0593700450464967 4547 675086
SGTC_2464 5717415 7.67 µM -1.56375170495809 0.102550477207919 no 3011 0.0589379450100115 4494 5285744
SGTC_2070 5230947 200 µM -1.56701108265565 0.102055030482042 no 3012 0.058556050575641 4611 2835538
SGTC_670 4204-0025 119 µM -1.56841918301222 0.101841529599557 no 3013 0.0583916685689104 4538 719039
SGTC_1061 3448-9325 110 µM -1.57027831175437 0.101560140528086 no 3014 0.058175188784015 4500 723482
SGTC_2018 5133068 143 µM -1.57085765072419 0.101472570295321 no 3015 0.058107858687109 4496 785362
SGTC_2830 7992007 71.43 µM -1.57416595542557 0.100973555646064 no 3016 0.057724543874958 4430 1952075
SGTC_535 2293-4129 48.2 µM -1.57724619851957 0.100510551544485 no 3017 0.057369443309627 4524 396118 YIL048W NEO1
SGTC_491 tetrandrine 80.3 µM -1.57891268915887 0.100260701069282 no 3018 0.0571780425295847 4548 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2223 6903751 107.57 µM -1.58101961547653 0.0999454670540253 no 3019 0.0569367763833795 4516 5598863
SGTC_3266 9136860 49.47 µM -1.58125060291734 0.099910951261662 no 3020 0.0569103746228779 4294 4871271 YPR165W RHO1
SGTC_3059 1327-0034 3 µM -1.58534732556474 0.0993002354634808 no 3021 0.0564437209913141 4399 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1568 digitonin 820 nM -1.58817324406313 0.0988805574338503 no 3022 0.0561235847708987 4519 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2028 5153890 36.43 µM -1.59082338873763 0.0984881641886086 no 3023 0.055824663874984 4525 2830968 YPR165W RHO1
SGTC_2188 6126565 140.678 µM -1.59120547292244 0.0984316851226039 no 3024 0.0557816708032629 4454 874518
SGTC_1989 st071868 50.2 µM -1.59435312137267 0.0979673070459915 no 3025 0.0554284829470825 4543 16414057
SGTC_77 0828-0286 12.516 µM -1.59515250661123 0.0978496284019957 no 3026 0.0553390681468233 4433 745345
SGTC_619 1652-1634 108 µM -1.5973211499782 0.0975309011950379 no 3027 0.0550970693295964 4534 5400454
SGTC_1327 1436-0082 2.18 µM -1.59789426443685 0.0974467974546786 no 3028 0.0550332553842822 4564 15992205
SGTC_674 0498-0004 451 µM -1.60183632122072 0.0968697471355335 no 3029 0.054595904465154 4540 4231473
SGTC_2030 5175110 200 µM -1.6028560629547 0.0967208835093798 no 3030 0.0544832179741156 4546 2831986
SGTC_1355 1499-0035 1.68 µM -1.60505498222406 0.0964004534393326 no 3031 0.0542408525990473 4545 1548538
SGTC_893 0958-0369 48.9 µM -1.60524520271719 0.0963727709047754 no 3032 0.0542199266085892 4413 6819948
SGTC_3022 9087993 49.47 µM -1.61012919872617 0.0956640087388838 no 3033 0.053684826958094 4616 17173644
SGTC_1040 k898-0338 155 µM -1.61144792379114 0.0954732954868935 no 3034 0.0535410644948473 4529 20969351
SGTC_2502 avocadyne acetate 18.59 µM -1.61741037495577 0.0946145015717446 no 3035 0.0528948638496317 4494 3952079
SGTC_2302 7771753 200 µM -1.62079387466521 0.0941297031215957 no 3036 0.0525309263077177 4534 2203047
SGTC_1817 st052116 64.4 µM -1.63023776635016 0.0927862526551968 no 3037 0.0515256274397518 4578 4361398
SGTC_1312 1218-2183 165 µM -1.63095853664525 0.09268430411266 no 3038 0.0514495343975301 4611 6744073
SGTC_1810 st050138 53 µM -1.63302536495505 0.0923924233438501 no 3039 0.0512318310395661 4567 3444541
SGTC_1282 0886-0010 32.4 µM -1.63534304413855 0.0920659266767937 no 3040 0.050988577457812 4571 2836211 YNL267W PIK1
SGTC_1953 st076800 12.1 µM -1.63595526548863 0.0919798244842042 no 3041 0.0509244750892435 4522 297591
SGTC_346 4513-0042 7.16 µM -1.63644789574714 0.0919105847689299 no 3042 0.0508729410478378 4507 2827372
SGTC_1674 st016616 23.6 µM -1.64119614364112 0.0912451915166718 no 3043 0.0503783529904313 4527 625830
SGTC_1842 st055362 61.2 µM -1.64154477903604 0.0911964767977936 no 3044 0.0503421898766835 4527 676032
SGTC_814 3342-0569 96 µM -1.64235614240864 0.0910831799109384 no 3045 0.0502581091924569 4600 4346283
SGTC_1115 galangin 695.678 nM -1.64681846609579 0.0904619368047852 no 3046 0.049797682295542 4628 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.65098873811261 0.0898842021178674 no 3047 0.0493704372557334 4547 6708760
SGTC_3138 9097216 49.47 µM -1.65244369691191 0.0896832839168828 no 3048 0.0492220669447144 4491 25237486
SGTC_854 0422-0053 192 µM -1.65588013876911 0.0892100647018362 no 3049 0.0488730472448809 4592 3596728
SGTC_1959 st077091 55.8 µM -1.65758259125537 0.0889763158772726 no 3050 0.0487008729339967 4566 821356 YKL052C ASK1
SGTC_976 1348-1067 47.6 µM -1.65873411587008 0.0888184688094495 no 3051 0.0485846907981945 4587 5310671 YGL099W LSG1
SGTC_771 0250-0039 27.3 µM -1.65982304890309 0.0886693934863761 no 3052 0.048475027749223 4518 3005115
SGTC_3130 9127414 49.47 µM -1.66071114562935 0.0885479507596868 no 3053 0.0483857369214216 4604 1494646
SGTC_1976 st070609 63.5 µM -1.66391913808278 0.0881103061581259 no 3054 0.0480642949532488 4527 682556
SGTC_1417 3966-0327 90.4 µM -1.66747375132618 0.0876272600496204 no 3055 0.0477101197829433 4640 651118
SGTC_75 0159-0059 199.013 µM -1.67185348366829 0.0870348068109838 no 3056 0.0472766086444273 4603 5377270
SGTC_1557 sumaresinolic acid 42.3 µM -1.67366195782883 0.0867910463293502 no 3057 0.0470985271500364 4563 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2763 lisinopril 49.32 µM -1.67436020706977 0.0866970673908305 no 3058 0.047029914215362 4480 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1603 st002045 67.8 µM -1.67458409141338 0.0866669504002323 no 3059 0.0470079313659622 4565 5887985
SGTC_1642 st009582 77.7 µM -1.6764847236465 0.0864115916554029 no 3060 0.0468216430000513 4568 6739311
SGTC_1089 terbinafine 2.25 µM -1.67949600820455 0.0860081640169849 no 3061 0.046527708089865 4587 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2483 5729050 27.16 µM -1.68191850185507 0.0856846420524725 no 3062 0.0462923222128944 4562 2865180
SGTC_706 4262-0057 46.9 µM -1.68321175794996 0.0855123022501325 no 3063 0.0461670527264901 4566 883298
SGTC_912 3474-0017 2.18 µM -1.68387270171998 0.0854243249275032 no 3064 0.0461031365138244 4582 3360550
SGTC_3207 9114163 49.47 µM -1.68577269344105 0.0851717971980811 no 3065 0.0459197946002042 4553 849233
SGTC_2913 7966556 36.57 µM -1.69147739750465 0.0844169468298211 no 3066 0.0453728305420655 4492 2976516
SGTC_1438 4092-1045 4 µM -1.69443871326382 0.0840270880313404 no 3067 0.0450909741701353 4616 1351342
SGTC_2984 9022109 38.96 µM -1.7013916598544 0.083117044234262 no 3068 0.0444347331778554 4595 6459207
SGTC_1170 0310-0127 64.8 µM -1.70201864379172 0.083035346512578 no 3069 0.0443759366849906 4607 774975
SGTC_3092 9117248 49.47 µM -1.70411653940679 0.0827624241026219 no 3070 0.044179658642574 4698 17141857
SGTC_972 1319-0219 195 µM -1.70923941617057 0.0820988088970263 no 3071 0.04370330518976 4582 23903702
SGTC_805 3852-0218 479 µM -1.70956421647785 0.0820568699329471 no 3072 0.0436732437059488 4576 6615355
SGTC_1653 st012112 65 µM -1.71839890899293 0.0809222952151283 no 3073 0.0428619396075986 4567 720429
SGTC_524 r073-0010 27.8 µM -1.71898517562164 0.0808474263901712 no 3074 0.0428085356417237 4545 2772106
SGTC_622 1348-1566 26.3 µM -1.72175635318513 0.0804942425165895 no 3075 0.042556832110293 4602 7340407
SGTC_2561 acetosyringone 100 µM -1.72201664015213 0.0804611291707921 no 3076 0.0425332520922518 4558 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_960 1222-0186 7.7 µM -1.72216830170043 0.0804418397453886 no 3077 0.0425195175826906 4586 3126296
SGTC_1504 k297-0033 30 µM -1.72814385156035 0.0796846032846649 no 3078 0.0419812186397389 4510 4388117
SGTC_1215 3852-0577 11.2 µM -1.72852735942523 0.0796361889990007 no 3079 0.0419468601334042 4623 2884876
SGTC_777 1315-0167 517 µM -1.72858297445609 0.0796291699689016 no 3080 0.0419418794680443 4621 4221767
SGTC_1785 bathophenanthroline 24 µM -1.7296539809527 0.0794940922721775 no 3081 0.0418460576558953 4540 72812 An iron chelator.
SGTC_408 cantharidin 100 µM -1.73445493380985 0.0788907156642304 no 3082 0.041418697653486 4602 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_659 k018-0002 107 µM -1.73475939453335 0.0788525688008652 no 3083 0.0413917155838043 4580 6797879 YHR007C ERG11
SGTC_692 k241-0027 77.8 µM -1.73528462500569 0.0787867938358959 no 3084 0.041345201833986 4628 3600480
SGTC_2104 5389443 200 µM -1.74089676488866 0.0780865749086055 no 3085 0.0408508379498239 4609 2244536
SGTC_3098 9119039 49.47 µM -1.74772223240575 0.0772413452476887 no 3086 0.0402560685681432 4597 17161528
SGTC_313 3474-0040 5.03 µM -1.74792391623245 0.0772164759409052 no 3087 0.0402386014530167 4624 1043375 YIL048W NEO1
SGTC_1879 gemcitabine 100 µM -1.75040327937988 0.0769112465666632 no 3088 0.0400243752759297 4588 60750 A nucleoside analog which inhibits DNA replication.
SGTC_804 1595-0054 20.9 µM -1.75260661348191 0.0766407690383839 no 3089 0.0398347776459885 4605 761523 Stimulates phospholipase C.
SGTC_2436 5633522 8.09 µM -1.75754263223444 0.076037458160525 no 3090 0.0394126809279397 4589 5724242
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.75803502414092 0.0759774738524962 no 3091 0.0393707750684002 4560 4000243
SGTC_1760 st045453 10.4495 µM -1.75908628615355 0.075849527298111 no 3092 0.0392814269294659 4617 3323419 YIL048W NEO1
SGTC_1795 st049545 62.3 µM -1.76047104804099 0.0756812417965887 no 3093 0.0391639860988933 4580 5291882
SGTC_2351 9026858 72.31 µM -1.7715801719055 0.0743414652132196 no 3094 0.0382321367543722 4517 1409300
SGTC_2862 9027634 71.43 µM -1.77248074680049 0.0742336532274189 no 3095 0.0381573942526157 4575 5012562
SGTC_1085 doxorubicin 7.67 µM -1.77508454407428 0.0739226123168505 no 3096 0.0379419643055824 4639 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2002 4023503 131 µM -1.78278357981818 0.0730087364300846 no 3097 0.0373107698494266 4598 4736863 YCR052W RSC6
SGTC_1128 3448-9350 235 µM -1.78913113763991 0.0722618052449178 no 3098 0.0367968492785775 4578 619386
SGTC_888 0916-0002 6.97 µM -1.7917570996846 0.0719545204698959 no 3099 0.0365859417823996 4620 2802138 YIL048W NEO1
SGTC_1033 k072-0102 21.3 µM -1.79449698407784 0.071634973840818 no 3100 0.036366939780296 4571 5965931
SGTC_896 0964-0007 44.5 µM -1.79789363209779 0.0712403431353767 no 3101 0.0360969327241718 4594 6756758
SGTC_1150 3909-7983 10.9 µM -1.80000872385221 0.0709954512691589 no 3102 0.0359296303688202 4631 23965914
SGTC_1547 harmine 94.2 µM -1.80438390059262 0.0704909324124028 no 3103 0.0355855725636323 4554 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_488 nitrendipine 139 µM -1.80802646491849 0.0700730003058296 no 3104 0.0353011908680998 4635 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1422 4031-0024 15.5 µM -1.81227577195137 0.0695878650754413 no 3105 0.0349717981070273 4586 782427
SGTC_1880 MG-132 525 µM -1.81627843261208 0.0691332581597459 no 3106 0.0346638359591919 4599 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_608 k048-0125 159 µM -1.82269258900745 0.0684095392406545 no 3107 0.0341749816890856 4666 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1950 st077106 7.18 µM -1.82269650890937 0.068409098746424 no 3108 0.034174684676157 4552 13831864
SGTC_1330 1469-0054 61.8 µM -1.82280516468983 0.0683968895557176 no 3109 0.0341664526179501 4599 7102664
SGTC_1209 2323-2347 50.3 µM -1.82371106466291 0.0682951628373954 no 3110 0.0340978826012489 4637 5412760
SGTC_2256 7954252 200 µM -1.8257210354958 0.0680698730425268 no 3111 0.0339461464725006 4642 2972920
SGTC_768 0384-0033 77.3 µM -1.82662506771263 0.0679687308438187 no 3112 0.0338780808322795 4599 3965305 YMR134W ERG29
SGTC_1310 1188-0297 994 nM -1.83122892647951 0.0674554550836858 no 3113 0.0335331904442862 4536 1588352
SGTC_1694 st024011 44.9 µM -1.83154901126342 0.0674198810973171 no 3114 0.0335093196763932 4671 2787533
SGTC_3134 9127454 49.47 µM -1.83433154530418 0.0671112429460477 no 3115 0.033302397137889 4656 24262820
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.83903789520714 0.0665917038376475 no 3116 0.0329548062441719 4590 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2456 5770359 74.46 µM -1.83917080788029 0.0665770767908926 no 3117 0.0329450334601623 4595 3118787
SGTC_471 1-acyl-paf 4 µM -1.84178973745727 0.066289370447576 no 3118 0.0327529558928443 4621 16759367
SGTC_2519 cryptotanshinone 88.04 µM -1.84428449739761 0.0660162012923246 no 3119 0.0325708447879093 4649 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3142 9086498 49.47 µM -1.84430257852342 0.0660142246486109 no 3120 0.0325695279665636 4516 25236367
SGTC_1384 3089-0840 101 µM -1.8563819691728 0.064703914486885 no 3121 0.0316995664608425 4638 1069836
SGTC_829 1635-0120 117 µM -1.85650728239415 0.0646904277899506 no 3122 0.0316906429941125 4622 285054
SGTC_94 0334-0113 514.748 µM -1.86181556108577 0.0641211326790447 no 3123 0.0313145461580359 4651 6795178
SGTC_1435 4092-0789 56.7 µM -1.86308542085967 0.0639855234766003 no 3124 0.0312251245390446 4664 2248285
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.86431882149084 0.0638540213716434 no 3125 0.0311384726168262 4637 688803
SGTC_898 1000-0849 28.3 µM -1.86535004995239 0.0637442357835463 no 3126 0.0310661769718481 4657 6751807
SGTC_1208 2323-2347 50.3 µM -1.86967005595174 0.0632859190506797 no 3127 0.0307648251058052 4651 5412760
SGTC_3222 9128301 49.47 µM -1.87022313828609 0.0632274273364691 no 3128 0.0307264189314285 4589 4911358
SGTC_3343 9148379 18.9835 µM -1.87213901868978 0.0630251371080137 no 3129 0.0305936865313482 4660 1955036
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.88399043918902 0.0617849769560611 no 3130 0.0297831343620404 4639 688798
SGTC_1005 4092-0690 4.4 µM -1.88645550580896 0.0615294359635262 no 3131 0.0296167994334272 4656 1529343
SGTC_106 0092-0003 11.579 µM -1.88996299668047 0.0611672558455388 no 3132 0.029381454579272 4607 1072148
SGTC_1967 st070177 51.4 µM -1.89110660971733 0.0610495283119604 no 3133 0.0293050571882822 4660 5729214
SGTC_545 4218-0007 221 µM -1.8941752008232 0.0607345119289285 no 3134 0.0291008793248016 4658 2840508
SGTC_1616 st002734 56.1 µM -1.89626976952884 0.0605202180753956 no 3135 0.0289621907779188 4637 4026101
SGTC_2285 7945142 200 µM -1.89902120970245 0.060239619638579 no 3136 0.0287808436844881 4654 2970608
SGTC_1827 berberine 7.24 µM -1.89977409608441 0.0601630162149379 no 3137 0.0287313858669299 4587 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_217 ketoconazole 989 nM -1.91344027602569 0.0587857477650938 no 3138 0.0278458562225583 4480 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_643 k048-0106 28.4 µM -1.91831308069525 0.0583006976897931 no 3139 0.0275356623977599 4691 6763920
SGTC_922 1866-0035 480 µM -1.92064035900989 0.0580701471039273 no 3140 0.0273885316853035 4602 3156169
SGTC_1498 4478-3555 97.6 µM -1.92195220191234 0.0579405061810953 no 3141 0.0273058862011592 4674 3437919
SGTC_809 3998-0021 90 µM -1.93664017435678 0.0565044735917854 no 3142 0.0263946717402779 4642 715485
SGTC_2962 9082311 13.18 µM -1.94001413628561 0.0561785982529659 no 3143 0.026188985958448 4653 16459453
SGTC_329 k048-0121 21.3 µM -1.94174973094032 0.0560115433946395 no 3144 0.0260837025493706 4681 6832902
SGTC_1056 3448-1962 115 µM -1.94505259542092 0.0556947178156039 no 3145 0.0258843242376733 4628 715507
SGTC_617 3770-0098 35 µM -1.9458519186806 0.0556182560955268 no 3146 0.0258362649819891 4615 5962639
SGTC_3066 9117245 49.47 µM -1.94598484948121 0.0556055482307493 no 3147 0.0258282797727389 4689 17176980
SGTC_1377 2944-0135 198 µM -1.9477468709322 0.0554373196555205 no 3148 0.0257226293791362 4660 1894137
SGTC_2367 9070478 135.38 µM -1.94835964762527 0.0553789092131642 no 3149 0.0256859723080863 4613 572802
SGTC_2569 tetrandrine 100 µM -1.95139727102892 0.0550900773537489 no 3150 0.0255049029313811 4651 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_649 1123-0311 367 µM -1.95517946720015 0.0547321128947035 no 3151 0.0252809456028738 4580 693629 YIL048W NEO1
SGTC_1640 st009078 66.4 µM -1.95740035792049 0.0545227760010865 no 3152 0.0251502082257013 4656 690618
SGTC_2806 7952793 58.44 µM -1.96155110195076 0.054133232911969 no 3153 0.0249073849741908 4663 2972490
SGTC_2332 7982454 138.89 µM -1.96239586251002 0.0540542234038567 no 3154 0.0248582070511356 4582 2981748
SGTC_1677 st019204 53.9 µM -1.96344875165604 0.0539558756743324 no 3155 0.0247970268981733 4672 3945625
SGTC_2271 7849410 118.62 µM -1.96363766481448 0.0539382447689147 no 3156 0.0247860631091451 4622 972430
SGTC_2647 atorvastatin 60.16 µM -1.96436736720915 0.053870185864769 no 3157 0.0247437521826945 4680 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1349 flufenamic acid 69 µM -1.96510946535563 0.0538010405733472 no 3158 0.0247007846611437 4617 3371 A non-steroidal anti-inflammatory.
SGTC_1406 3909-7906 11.9 µM -1.98136310799228 0.0523041560161633 no 3159 0.0237752839304232 4696 X1406
SGTC_296 1222-0039 74.9 µM -1.98885979293706 0.0516249829484215 no 3160 0.0233583403925172 4690 5984176
SGTC_361 000s-0510 1.45 µM -1.99154374868203 0.0513835375099403 no 3161 0.0232105702728496 4599 660
SGTC_1553 gossypol 38.6 µM -1.99337811465184 0.0512190374778377 no 3162 0.023110029255072 4660 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_384 k007-0144 5.16 µM -1.99620305571859 0.0509665256680021 no 3163 0.0229559124945914 4659 6824886
SGTC_1895 st058434 18.3 µM -2.00213104704151 0.0504398646722044 no 3164 0.0226353195900538 4683 5393175
SGTC_3146 9095609 49.47 µM -2.00589874485453 0.050107390820809 no 3165 0.0224335261029483 4693 17173999
SGTC_845 0330-0138 4.51 µM -2.0099689093535 0.0497501920133568 no 3166 0.0222172397738433 4667 9039800
SGTC_97 0535-0701 19.132 µM -2.01145476843139 0.0496202998792105 no 3167 0.0221387216806487 4605 2832013 YGL099W LSG1
SGTC_2796 7949634 45.45 µM -2.0187449228351 0.0489869192272399 no 3168 0.0217568691245251 4649 2971588
SGTC_2291 7917025 104.35 µM -2.0207074820035 0.0488175169157018 no 3169 0.0216550274299888 4612 2964612
SGTC_642 0335-0876 158 µM -2.03230305925745 0.0478261546316214 no 3170 0.021061492480791 4733 6812350
SGTC_2182 6325192 200 µM -2.03662583820238 0.0474607296691644 no 3171 0.0208437757401586 4709 736248
SGTC_2178 5812956 200 µM -2.0400302740708 0.0471745140497295 no 3172 0.0206736552612431 4673 5403383
SGTC_1219 1469-0211 33.1 µM -2.04320245838035 0.0469090709721785 no 3173 0.02051620024789 4703 6822282
SGTC_1392 3455-1037 33.9 µM -2.04384558375837 0.0468554016397022 no 3174 0.0204844021649343 4703 981132
SGTC_1261 0712-0010 12.7 µM -2.05172016262738 0.0462022471576417 no 3175 0.0200984330492647 4683 2840123
SGTC_470 aa-861 153 µM -2.05200521630599 0.0461787413020308 no 3176 0.0200845777366968 4658 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3083 9117465 49.47 µM -2.05286552152785 0.0461078577686874 no 3177 0.0200428108713763 4653 16420915
SGTC_1427 4048-4900 550 nM -2.05373676540105 0.0460361620559703 no 3178 0.0200005880567677 4704 24132586
SGTC_3141 9094609 49.47 µM -2.05471372229591 0.0459558736361394 no 3179 0.0199533318762599 4648 25236309 YDL196W YDL196W
SGTC_1381 2324-0066 62.1 µM -2.05861741742456 0.0456361818191762 no 3180 0.0197654514486899 4699 10885928
SGTC_2520 obtusaquinone 4.71 µM -2.08963315790709 0.0431592412482265 no 3181 0.0183253827983036 4709 5967872
SGTC_2817 7995342 71.43 µM -2.09528785063861 0.0427195769209044 no 3182 0.0180727059132685 4673 18879975
SGTC_3301 9125354 19.7965 µM -2.09951069361888 0.0423936091773037 no 3183 0.0178859530770371 4688 41905162
SGTC_1643 st009866 20.2 µM -2.09969082901059 0.0423797491156347 no 3184 0.0178780234299017 4702 3156273 YOR207C RET1
SGTC_2685 mycophenolic acid 18.85 µM -2.09985349206207 0.0423672365685711 no 3185 0.0178708655001387 4722 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_426 0988-0037 14.6 µM -2.10306529207016 0.0421207864177143 no 3186 0.0177300312094344 4688 5383008
SGTC_1711 st032263 62.8 µM -2.11495048575305 0.0412188763371699 no 3187 0.017217083813222 4703 3958979
SGTC_1166 k206-0078 225 µM -2.11521404434741 0.0411990549968573 no 3188 0.0172058542407751 4700 5404595
SGTC_2734 clemastine 41.6 µM -2.12051599470239 0.0408019522557029 no 3189 0.0169812770568 4766 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_894 0960-0238 55.9 µM -2.12827458233454 0.0402264565048372 no 3190 0.0166571621195326 4712 6741907 YDL195W SEC31
SGTC_2180 6301957 200 µM -2.13329069186989 0.0398579068649383 no 3191 0.0164504436588228 4717 845462
SGTC_2539 epi(13)torulosol 80 µM -2.13363372392481 0.0398328037978975 no 3192 0.0164363875810304 4666 6708597
SGTC_1818 st052136 56.3 µM -2.13608159015463 0.0396540419445535 no 3193 0.0163363820250185 4433 674169
SGTC_1514 1189-1591 158 µM -2.136456153219 0.0396267461315199 no 3194 0.0163211256213662 4705 767698 YMR146C TIF34
SGTC_251 melphalan 456.522 µM -2.14051169440806 0.039332180927356 no 3195 0.0161567183701049 4737 460612 A DNA alkylator.
SGTC_2031 5180455 200 µM -2.14257168236826 0.0391832420411669 no 3196 0.0160737535124377 4719 29949
SGTC_1032 k061-1018 98.7 µM -2.14506405829133 0.0390036551625026 no 3197 0.0159738628125154 4731 4005393
SGTC_2100 5377183 190 µM -2.14802324195946 0.0387913034987478 no 3198 0.0158559545738355 4730 2844202
SGTC_2159 5658611 73.75 µM -2.14864569398885 0.0387467562998001 no 3199 0.0158312482905289 4706 793844
SGTC_586 0957-0265 8.15 µM -2.15119818863518 0.0385645168407929 no 3200 0.0157302799784476 4658 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1558 st069300 45.6 µM -2.15165740841412 0.0385318043610859 no 3201 0.0157121735030835 4715 24208000
SGTC_2824 7998404 51.95 µM -2.1577169183254 0.0381022699097756 no 3202 0.0154749238781043 4693 837851
SGTC_2679 rapamycin 1 nM -2.16950982077019 0.0372775160065507 no 3203 0.0150219997909592 4579 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_255 tunicamycin 200.472 nM -2.17106233852615 0.0371700330603225 no 3204 0.0149632302178764 4667 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2051 5263410 176 µM -2.18128231024748 0.0364687951408837 no 3205 0.0145812710056818 4674 227584
SGTC_294 k038-0071 157 µM -2.18195810379924 0.0364228101097247 no 3206 0.0145563124716998 4743 24152826
SGTC_2170 morpholine 200 µM -2.19452140807432 0.0355765348362233 no 3207 0.0140989733159212 4734 121171 Reacts with secondary amines.
SGTC_3156 9099931 49.47 µM -2.2029637455035 0.0350169582303359 no 3208 0.0137986520192895 4746 18111053
SGTC_1346 1488-2224 62.4 µM -2.20314093350402 0.0350052916625165 no 3209 0.0137924084439757 4725 3722427
SGTC_1637 st007924 17.4 µM -2.22208268252523 0.0337763885717176 no 3210 0.0131388591867994 4674 683336
SGTC_1084 voriconazole 435 nM -2.22236665477132 0.0337582386183187 no 3211 0.0131292684592696 4751 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1927 st060202 13.8 µM -2.22328169322493 0.0336998089451402 no 3212 0.0130984055831908 4686 688887
SGTC_444 curcumin 90.4 µM -2.22790742519815 0.0334057057501196 no 3213 0.0129433444693168 4645 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2009 4012297 12.05 µM -2.23148234945948 0.0331798632790239 no 3214 0.0128245977037011 4682 45595307
SGTC_1619 st003326 88.7 µM -2.24562589787004 0.0322986563288187 no 3215 0.0123639901103624 4709 2849032
SGTC_993 3909-8757 62.7 µM -2.25043890524443 0.0320032247032348 no 3216 0.0122105488321201 4714 4288324 YLR208W SEC13
SGTC_2587 piperic acid 92.2 µM -2.25102234695082 0.0319675640597288 no 3217 0.0121920610166436 4690 5370536
SGTC_451 chloral hydrate 100 µM -2.25379931385319 0.0317982820890997 no 3218 0.0121043980032858 4718 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_837 0091-0265 12.5 µM -2.25492506634887 0.0317298682822981 no 3219 0.0120690163217182 4736 759367
SGTC_2069 5228469 200 µM -2.25505848615292 0.0317217682110348 no 3220 0.0120648289716457 4722 2835210
SGTC_1202 1988-0068 29.6 µM -2.2769661257855 0.0304147154374258 no 3221 0.0113941242646272 4721 2850480
SGTC_1345 1488-0192 31.4 µM -2.28606367942585 0.0298852076497135 no 3222 0.0111252667189962 4753 658348
SGTC_612 0302-0167 22.4 µM -2.28778523131368 0.0297858729987498 no 3223 0.0110750156570359 4720 235821
SGTC_2485 5633444 17.78 µM -2.29365869571162 0.0294490296960298 no 3224 0.01090505551674 4707 5724239
SGTC_1780 st038448 24.544 µM -2.29661214544871 0.0292808479234819 no 3225 0.0108204525878047 4727 728868 YDL195W SEC31
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.30702100258716 0.0286944715617654 no 3226 0.0105268246432288 4735 6710655
SGTC_1815 st051655 58.2 µM -2.31940886296537 0.028009368847824 no 3227 0.0101864387702119 4734 5984156
SGTC_29 0299-0004 12.984 µM -2.33220751202174 0.0273159104128074 no 3228 0.00984488859275545 4695 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3201 9113999 49.47 µM -2.33440831384707 0.0271981211904637 no 3229 0.00978717593654991 4710 16649224
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.3347450213077 0.0271801376830186 no 3230 0.00977837241459618 4723 442882
SGTC_2158 5657123 3.6195 µM -2.33643271440331 0.0270901476047434 no 3231 0.00973435029793983 4748 2858827
SGTC_2397 5161689 200 µM -2.34305202868549 0.0267395933066495 no 3232 0.00956335782911001 4727 2259942
SGTC_2416 tofa 880 nM -2.34783777591075 0.0264885098541215 no 3233 0.00944137170286112 4714 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2135 5326629 150.42 µM -2.3479947467626 0.0264803078856329 no 3234 0.00943739375442753 4722 5020077
SGTC_2651 TUB2.036 5 µM -2.35381708035392 0.0261775778505236 no 3235 0.00929087623986939 4638 15992207 YFL037W TUB2
SGTC_990 3985-0011 41.3 µM -2.36005313571392 0.0258565516293578 no 3236 0.00913615881255244 4734 5399565 YGL099W LSG1
SGTC_1470 k295-0292 231 µM -2.36051318751345 0.0258329996445213 no 3237 0.00912483472276215 4778 5045612
SGTC_1469 k284-2957 126 µM -2.370507003006 0.0253257884612889 no 3238 0.00888185370697539 4770 23884841
SGTC_394 menadione 8.33 µM -2.38533598809151 0.0245885732404079 no 3239 0.00853176457342572 4739 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1263 0774-1208 64.8 µM -2.38655147592618 0.0245289527266392 no 3240 0.00850361312534851 4727 906585
SGTC_2662 daunorubicin 22.37 µM -2.39507161834774 0.0241144308924595 no 3241 0.00830855957461786 4666 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_304 1310-0298 97 µM -2.40088578658176 0.0238349511712281 no 3242 0.00817772022319053 4541 1550234
SGTC_2398 5228213 48.84 µM -2.40622619125529 0.0235806486523 no 3243 0.00805914077814842 4716 80771 YMR134W ERG29
SGTC_500 h-89 112 µM -2.40989945321136 0.0234070609826334 no 3244 0.00797845871785146 4730 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2731 amoxapine 43.43 µM -2.41264362837863 0.0232780820410731 no 3245 0.00791864807741115 4802 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3158 9100007 49.47 µM -2.41321492652939 0.023251305830847 no 3246 0.00790624606299674 4750 19297233
SGTC_2704 st078022 71.1 µM -2.41705526479105 0.0230719848566726 no 3247 0.00782332066351844 4756 54697681
SGTC_1962 st076595 64.5 µM -2.42870392229736 0.0225351706830918 no 3248 0.0075764505216784 4733 279619
SGTC_2307 7538926 6.34 µM -2.42922466594386 0.0225114208396514 no 3249 0.00756557640193573 4711 96582
SGTC_2621 lithochol-11-enic acid 100 µM -2.43390230159484 0.022299030066782 no 3250 0.00746851308513507 4719 6708711
SGTC_2354 9060492 162 µM -2.43907585184858 0.022066093366659 no 3251 0.00736243856191848 4747 6471895
SGTC_3249 9135183 49.47 µM -2.44098086152405 0.0219808401549852 no 3252 0.00732371549791213 4731 4902779
SGTC_2712 st079126 47.7 µM -2.4573774475723 0.0212584908117121 no 3253 0.00699777768112534 4766 3152970
SGTC_2184 6075246 200 µM -2.46168456431068 0.0210721055484233 no 3254 0.00691431137974066 4762 2267320
SGTC_3298 9116858 71.43 µM -2.49185455193012 0.0198049148891484 no 3255 0.00635390321887361 4783 2506942
SGTC_3038 9091290 49.47 µM -2.49242884181141 0.0197814351851964 no 3256 0.0063436374935458 4744 25236843
SGTC_2115 tiliquinol 12.7705 µM -2.49976519325693 0.0194835631372672 no 3257 0.00621378229713635 4745 71208 A bioactive hydroxyquinoline.
SGTC_1560 lithocholic acid 53.1 µM -2.50996985813205 0.0190755731597862 no 3258 0.00603707336520407 4743 9903 A bile acid which acts as a detergent.
SGTC_1607 st000305 50.6 µM -2.51309953902542 0.0189519110921146 no 3259 0.00598377814290312 4772 5457690
SGTC_1605 st000082 49.1 µM -2.51391018018948 0.0189199918967181 no 3260 0.00597004195548397 4755 1114022
SGTC_3203 9113543 49.47 µM -2.51718615385145 0.0187914650363501 no 3261 0.00591481545251885 4738 17018012
SGTC_952 1185-0122 232 µM -2.51958585421733 0.0186977892561384 no 3262 0.00587464917094065 4732 678600
SGTC_1529 apigenin 74 µM -2.5209321373467 0.0186454093928853 no 3263 0.00585222112997392 4760 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_459 nigericin 15.3 µM -2.53467569361997 0.0181177973727363 no 3264 0.00562757353588132 4768 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2675 theaflavin digallate 100 µM -2.5385746423476 0.0179704551014885 no 3265 0.0055652528425797 4724 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1467 k284-1082 293 µM -2.54793466765854 0.0176209025795138 no 3266 0.00541813813867538 4756 3334705
SGTC_2776 terbinafine 19.92 µM -2.5524064169932 0.0174559629477394 no 3267 0.00534908225288624 4754 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1000 4048-0884 8.67 µM -2.55650621648238 0.0173059027520919 no 3268 0.00528645909488967 4755 13040088
SGTC_2875 9039966 71.43 µM -2.55905139676726 0.017213299938585 no 3269 0.00524791112194066 4769 6463691
SGTC_994 3910-0338 138 µM -2.56054092915956 0.0171593020266319 no 3270 0.00522546761607869 4783 3479481
SGTC_2414 st077232 92.9 µM -2.56249214314591 0.017088786473491 no 3271 0.00519619694927776 4732 729801
SGTC_1876 myriocin 605 nM -2.56753853452204 0.016907560908096 no 3272 0.00512117023574715 4734 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2300 7976697 71.57 µM -2.57389903933901 0.0166814861909108 no 3273 0.00502798060968351 4704 2236109
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.60487864311982 0.0156169839755649 no 3274 0.00459534033085022 4753 61125 An anti-inflammatory.
SGTC_2904 7225135 42.03 µM -2.61172777188961 0.0153896704281982 no 3275 0.0045042978031293 4773 4446116
SGTC_1428 4049-0204 61.7 µM -2.61254865119526 0.0153626181204012 no 3276 0.00449349501023651 4783 X1428
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.61328347261303 0.0153384365205204 no 3277 0.00448384437321955 4775 279621
SGTC_2437 5741531 144.16 µM -2.62598776403578 0.0149255010411674 no 3278 0.0043198961563079 4759 2262990
SGTC_340 k038-0059 454 µM -2.6303474803903 0.014786014480967 no 3279 0.0042648817052172 4779 23733424
SGTC_2054 5233173 129 µM -2.64628429490561 0.0142856241523739 no 3280 0.00406906945883045 4763 6889
SGTC_2718 lomofungin 53.02 µM -2.65215920826003 0.0141048763858499 no 3281 0.0039989409942761 4755 5351222 A RNA synthesis inhibitor.
SGTC_320 4092-0846 5.34 µM -2.65360428184293 0.0140607203855882 no 3282 0.00398185794438963 4750 1359356
SGTC_1754 st042065 16.137 µM -2.66114788730941 0.0138321454762266 no 3283 0.00389373723807909 4633 1126236 YIL048W NEO1
SGTC_1696 st025591 34.7925 µM -2.6658701783725 0.0136906946269724 no 3284 0.00383946698231267 4771 2787147
SGTC_2337 9009472 200 µM -2.68187696214262 0.0132204753691955 no 3285 0.00366051901493762 4730 5742383
SGTC_293 4049-0273 38.5 µM -2.68805755748698 0.0130426827297546 no 3286 0.0035934503706749 4734 1380311
SGTC_360 0957-0399 1.01 µM -2.69042901400993 0.0129750155056147 no 3287 0.00356801075034682 4771 6752301 YPR165W RHO1
SGTC_971 1315-0384 26.7 µM -2.69278215409034 0.01290817116411 no 3288 0.00354292754488262 4783 6769120
SGTC_1715 st032160 10.2275 µM -2.69293953751299 0.0129037111048596 no 3289 0.00354125558467291 4712 5289825
SGTC_2315 7733312 200 µM -2.706670582958 0.012519684957894 no 3290 0.00339808285108468 4736 726316
SGTC_2549 cedrol 20.94 µM -2.71133374063844 0.0123915373682975 no 3291 0.00335065692869507 4772 6708665 A sedative which affects the nervous system.
SGTC_2037 5169046 200 µM -2.72361176070515 0.0120595468652735 no 3292 0.00322861819901491 4788 5718022
SGTC_1966 st070145 16.1 µM -2.80440171290689 0.0100613773209027 no 3293 0.00252050272461363 4778 3748532
SGTC_2246 7293507 91.5585 µM -2.81047535217246 0.00992356938735653 no 3294 0.00247341888937801 4783 887656
SGTC_3110 9122132 49.47 µM -2.81139534335861 0.00990283959975414 no 3295 0.00246635675705082 4775 918317
SGTC_9 0092-0002 10.449 µM -2.82126999458668 0.00968270814852595 no 3296 0.00239169626616071 4783 759368
SGTC_367 0335-0881 7.1 µM -2.82620491995178 0.00957430714883933 no 3297 0.00235515600283779 4740 23828853
SGTC_268 camptothecin 39.6153 µM -2.84473838270955 0.00917661630920139 no 3298 0.00222239564921845 4755 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1644 st010134 20.9 µM -2.84873625834131 0.00909275108165655 no 3299 0.00219466251391522 4791 3818134
SGTC_1097 itavastatin 7.23 µM -2.84898491797995 0.00908755707747542 no 3300 0.00219294797668422 4796 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_309 k408-0051 1.48 µM -2.89323747806114 0.00820359462035819 no 3301 0.00190646443131267 4740 3640463
SGTC_1884 5633444 25 µM -2.90875464994281 0.00791202785949312 no 3302 0.00181435757951666 4755 5724239
SGTC_2814 7977482 42.97 µM -2.91118247368906 0.00786724342206629 no 3303 0.00180031835247734 4778 6456762
SGTC_3296 9122258 64.045 µM -2.92069936635302 0.00769383468702337 no 3304 0.00174623330670535 4763 4730474
SGTC_1712 st032288 53.4 µM -2.94006905046943 0.00735125837849838 no 3305 0.00164069555624623 4695 2883011
SGTC_1556 plumbagin 1.48 µM -2.98337121514577 0.0066336265704996 no 3306 0.00142545993063305 4767 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_172 1112-0046 2.638 µM -2.98642140680188 0.00658549453264141 no 3307 0.00141131691022472 4780 2802135 YIL048W NEO1
SGTC_374 0880-0231 82.3 µM -3.01861950657563 0.00609593856532758 no 3308 0.0012696461437065 4732 6833587
SGTC_769 0302-0231 76 µM -3.02007196625775 0.00607463544595666 no 3309 0.00126357315065346 4757 571869 YER009W NTF2
SGTC_1139 k015-0024 46.9 µM -3.03990475712035 0.00579028060890623 no 3310 0.00118326486878067 4790 2766652
SGTC_1571 st070080 73.4 µM -3.04860661560523 0.00566928973016776 no 3311 0.00114952658836387 4786 4315245
SGTC_2275 7947463 200 µM -3.04922393643106 0.00566079236917181 no 3312 0.00114716695020645 4788 1225414
SGTC_335 4077-0256 27.6 µM -3.09206335509277 0.0050980395019932 no 3313 0.00099385210669442 4734 3121989
SGTC_2449 5812982 45.77 µM -3.10324627933138 0.00495958745005904 no 3314 0.000957051407536221 4766 776185
SGTC_1651 st011928 86.1 µM -3.11150483012425 0.00485950172477036 no 3315 0.000930682144629436 4799 720198
SGTC_1161 k007-0610 110 µM -3.14815011669429 0.0044367798240534 no 3316 0.000821536451531841 4765 5843850
SGTC_425 3825-7017 13.1 µM -3.15129143243591 0.00440211894114732 no 3317 0.000812751047840597 4786 3397440
SGTC_2912 7964298 10.93 µM -3.16713948318074 0.00423091602407781 no 3318 0.0007697322971857 4786 2975850
SGTC_551 k048-0028 34.9 µM -3.1981135817602 0.00391340695627814 no 3319 0.000691648924386156 4785 6836383
SGTC_1072 oxiconazole 14.9 nM -3.24829951749985 0.0034440757158191 no 3320 0.000580484953349501 4787 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1697 st025554 27.742 µM -3.25248711212237 0.00340729858925974 no 3321 0.000571998918296609 4807 1269519
SGTC_1968 st069590 43.6 µM -3.25881141905207 0.00335242472145591 no 3322 0.000559400048324181 4789 6384066
SGTC_352 k048-0007 5.11 µM -3.26009762895084 0.00334136240878764 no 3323 0.000556869349845975 4761 6811911
SGTC_1658 st012944 20 µM -3.4412770742046 0.00207453662801429 no 3324 0.000289487666303751 4761 24207260
SGTC_2778 tioconazole 65.09 nM -3.44178095023488 0.00207172494518194 no 3325 0.000288949005451822 4757 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_181 1447-1644 8.07 µM -3.46874645694955 0.00192620468442371 no 3326 0.000261446337406917 4784 534600
SGTC_453 enantio-paf c16 10 µM -3.5048390730148 0.00174596234277115 no 3327 0.000228441680734733 4498 13871343 A lipid and platelet activating factor
SGTC_2858 9025781 8.96 µM -3.50868758144018 0.00172767815181049 no 3328 0.000225161774443208 4737 4894980 YPL153C RAD53
SGTC_1212 0520-0165 585 µM -3.50930701505894 0.00172475157118545 no 3329 0.000224637984124304 4793 5403258
SGTC_2905 7799065 20.05 µM -3.54001730094331 0.00158519269130682 no 3330 0.000200050401131436 4794 1296806
SGTC_562 3772-2733 112 µM -3.58822646206255 0.00138675885637767 no 3331 0.000166467524144984 4795 2876874 YIL048W NEO1
SGTC_2586 curcumin 80 µM -3.60033376431538 0.00134062557051725 no 3332 0.000158904481780464 4783 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1114 scopoletin 1.73284 µM -3.61025560735942 0.00130387005786142 no 3333 0.000152947703560239 4808 5280460 A coumarin with genotoxic properties.
SGTC_1731 st035964 63 µM -3.67087907264137 0.00109859848234488 no 3334 0.000120858844632387 4784 6739575
SGTC_2249 haloperidol 116.36 µM -3.71250902928388 0.000975275427075276 yes 3335 0.000102607368645962 4784 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1112 tnp00069 1.16933 µM -3.77336780417002 0.000817736413224638 yes 3336 8.05292883909831e-05 4792 145826
SGTC_2490 carminic acid 95.39 µM -3.85441022290069 0.000644215125506372 yes 3337 5.80044710867134e-05 4796 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_151 3013-0144 2.285 µM -3.92124104308893 0.000527418520614328 yes 3338 4.40470429316284e-05 4740 906558 YHR107C CDC12
SGTC_2804 7954240 19.48 µM -4.01268154829272 0.000399163212243412 yes 3339 3.00164380462912e-05 4802 828705
SGTC_568 1193-0097 7.48 µM -4.02935141073966 0.000379161578771083 yes 3340 2.79654779000128e-05 4763 3646150
SGTC_178 4092-0806 87.505 µM -4.17503418846545 0.000239995376579347 yes 3341 1.48970652719366e-05 4793 2169044
SGTC_660 4031-1742 102 µM -4.18214952589844 0.000234606782153656 yes 3342 1.44382973572533e-05 4801 6738706
SGTC_2021 4019055 173 µM -4.2194835826754 0.000208135667705391 yes 3343 1.22431276103205e-05 4778 44827708 YER133W GLC7
SGTC_2061 5245884 80.95 µM -4.32726076884234 0.000146528208872936 yes 3344 7.54875909041987e-06 4809 573863
SGTC_2582 agaric acid 100 µM -4.47790267579713 8.8525846476644e-05 yes 3345 3.76899752769582e-06 4733 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -4.4954117001188 8.34052555145368e-05 yes 3346 3.4717734183525e-06 4803 676296 Flavone; oxidizing agent.
SGTC_2896 9052656 71.43 µM -4.50689328068338 8.02001101765935e-05 yes 3347 3.28918491504309e-06 4660 6469436
SGTC_978 1416-0512 87.4 µM -4.71731398390259 3.84848345011872e-05 yes 3348 1.19489364820616e-06 4808 6814003
SGTC_431 k089-0097 107 µM -4.81829635786106 2.67631435915454e-05 yes 3349 7.23946006999796e-07 4741 5499420
SGTC_1718 roemerine 11.9335 µM -4.89509946118994 2.02071177825335e-05 yes 3350 4.91280107424149e-07 4740 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -4.94926622826395 1.65337316468184e-05 yes 3351 3.72468961491863e-07 4810 688669
SGTC_2777 climbazole 1.536 µM -5.22969496575621 5.66394486718564e-06 yes 3352 8.48949780593855e-08 4783 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_339 3091-4833 71.4 µM -5.82239467418829 4.91394862711375e-07 yes 3353 2.90051792125899e-09 4806 3240077
SGTC_1707 st032323 6.317 µM -6.32556776397113 5.08381050143173e-08 yes 3354 1.26151575838959e-10 4810 3132057 YMR211W DML1
SGTC_1787 fluconazole 80 µM -6.63023199649034 1.18037099880878e-08 yes 3355 1.6757983964374e-11 4783 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3303 9125618 40.5795 µM -9.41058452233156 9.1909085313217e-16 yes 3356 2.46692698877235e-21 4810 22695467