SGTCid condition conc unit SSN3|YPL042C.score SSN3|YPL042C.strain.pval SSN3|YPL042C.strain.significant SSN3|YPL042C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_682 0kpi-0099 17 µM 12.8273924491046 2.20322080448763e-27 yes 1 5.75878070147921e-38 3 1714895 YML126C ERG13 SGTC_1877 wortmannin 25 µM 10.9879413216869 1.32057258027998e-20 yes 2 2.18387466491667e-28 8 312145 A covalent inhibitor of PI 3-kinase. SGTC_1712 st032288 53.4 µM 8.3683190856295 1.01234537130067e-12 yes 3 2.92229751283762e-17 39 2883011 SGTC_1803 st050068 52.4 µM 7.18340465845 7.81456628563561e-10 yes 4 3.39982296434685e-13 52 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2688 kanamycin b 96.69 µM 7.15834482458419 8.90086233877979e-10 yes 5 4.08284742868846e-13 102 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2540 epiandrosterone 100 µM 6.33066358113894 5.14169697725199e-08 yes 6 1.22054532378275e-10 19 441302 A steroid. SGTC_86 0417-1630 471.922 µM 6.31549405379618 5.51429454389539e-08 yes 7 1.34649871041118e-10 83 3634867 SGTC_174 3553-0389 74.3 µM 6.12654137680621 1.30082850701264e-07 yes 8 4.4904929675411e-10 3 738071 SGTC_187 1488-2104 32.728 µM 5.83669113625848 4.62805169553114e-07 yes 9 2.66238356491866e-09 16 2852859 SGTC_1723 st034307 2.5525 µM 5.72499256623933 7.43298882661167e-07 yes 10 5.17191350413689e-09 8 867466 SGTC_528 3492-0019 172 µM 5.57201183602138 1.4027911093994e-06 yes 11 1.259071543129e-08 135 2869262 SGTC_1683 st010134 710 nM 5.55525930669388 1.502375905176e-06 yes 12 1.3859997109704e-08 7 3818134 SGTC_1801 st050089 28.441 µM 5.43708726636076 2.4240096261554e-06 yes 13 2.70793082642918e-08 57 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2063 5246145 200 µM 5.33180858125556 3.68261585550633e-06 yes 14 4.86197049660441e-08 9 711240 SGTC_1800 st050079 29.0735 µM 5.32853402467819 3.73038116418609e-06 yes 15 4.95043256562384e-08 64 3645560 SGTC_3337 9144342 33.5465 µM 5.3253390759966 3.77755586067016e-06 yes 16 5.03824458395735e-08 15 17682949 SGTC_515 4092-1064 102 µM 5.30272143649678 4.12820235956189e-06 yes 17 5.70444733258333e-08 32 717353 SGTC_1231 0242-0792 125 µM 5.10373278414531 8.88056425971246e-06 yes 18 1.66509210518119e-07 7 3707635 SGTC_88 0180-0332 8.668 µM 4.86400108141928 2.15679212017948e-05 yes 19 5.75181420424967e-07 7 3101745 SGTC_2199 6590217 200 µM 4.77356993013079 2.98405670032322e-05 yes 20 9.04943320002018e-07 1 703109 SGTC_1687 st020778 55.3625 µM 4.7447347979957 3.30570434017827e-05 yes 21 1.0438984134288e-06 141 4259299 SGTC_1022 4477-0945 21.3 µM 4.64136417281074 4.74944819116401e-05 yes 22 1.7305825201762e-06 11 4648966 SGTC_2842 9000675 19.48 µM 4.5346444400532 6.85258413831591e-05 yes 23 2.8850302196463e-06 12 2989072 SGTC_89 0302-0250 142.109 µM 4.52879124148111 6.99021696271321e-05 yes 24 2.96610361784168e-06 9 4203518 YLR208W SEC13 SGTC_3128 9127691 49.47 µM 4.44938738512279 9.13409186898788e-05 yes 25 4.30577845033525e-06 14 41316314 SGTC_710 3448-4187 58 µM 4.28863038102439 0.000154975432408212 yes 26 8.98891283186416e-06 48 3946412 SGTC_902 1120-0002 2.07 µM 4.23447980007099 0.000184465908125671 yes 27 1.14540687210681e-05 41 3280475 SGTC_2834 9001755 58.44 µM 4.21115086012272 0.000198722609322274 yes 28 1.27036498455249e-05 27 2989575 SGTC_1597 7-benzyloxygramine 47.5 µM 4.11656847506311 0.000267741661491241 yes 29 1.92277556887375e-05 111 260807 SGTC_1291 0993-0025 5.79 µM 4.07537030892418 0.000304300396960971 yes 30 2.2970590391358e-05 11 4353356 SGTC_3138 9097216 49.47 µM 4.0376228035746 0.000341824919093472 yes 31 2.6997790264796e-05 12 25237486 SGTC_1707 st032323 6.317 µM 4.02825479220298 0.00035178174941781 yes 32 2.80962134996634e-05 54 3132057 YMR211W DML1 SGTC_1624 st003710 6.25 µM 4.02408522369182 0.000356299498176024 yes 33 2.8598601701945e-05 36 24207033 SGTC_1812 st052057 4.327 µM 4.00026763848352 0.000383156290012539 yes 34 3.16354428806486e-05 23 3645418 SGTC_1048 3161-0300 24.5 µM 3.97990500827315 0.000407595212068683 yes 35 3.44714055371967e-05 23 2165101 SGTC_268 camptothecin 39.6153 µM 3.94562350217067 0.000452030993952204 yes 36 3.97962971124048e-05 72 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1112 tnp00069 1.16933 µM 3.93191898950774 0.000471019333034484 yes 37 4.21352328859828e-05 21 145826 SGTC_2730 imipramine 71.33 µM 3.90648177345175 0.000508236107020115 yes 38 4.68248518967357e-05 26 3696 A tricyclic antidepressant. SGTC_505 gw-5074 63.9 µM 3.87632125249683 0.000555883901497431 yes 39 5.30238250943494e-05 59 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2575 plumbagin 510 nM 3.77954772958405 0.000738069475401684 yes 40 7.85567378050461e-05 50 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2191 5911152 200 µM 3.7480280091665 0.000808382274662299 yes 41 8.91151774671588e-05 19 2875902 SGTC_1949 st076024 69.1 µM 3.72688374486994 0.000858950731209488 yes 42 9.69309106132112e-05 35 2921930 SGTC_892 0929-0076 29 µM 3.69897202225098 0.000930160916875717 yes 43 0.000108237229551353 51 5751038 SGTC_884 0851-0618 334 µM 3.6703968188132 0.00100864787285268 no 44 0.000121087107066132 21 9642473 SGTC_263 alizarin 107.927 µM 3.66842716192771 0.0010142756708564 no 45 0.000122023599291334 72 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1011 4112-3381 17.4 µM 3.59925432824744 0.00123116782791879 no 46 0.000159565481068639 53 2877139 SGTC_1353 1498-1206 8.11 µM 3.59414015767893 0.00124877851045222 no 47 0.000162732305896698 68 6756808 SGTC_2896 9052656 71.43 µM 3.54673023947292 0.00142334955463572 no 48 0.00019502187767755 147 6469436 SGTC_319 1348-1596 45.5 µM 3.53915724593713 0.00145321344748394 no 49 0.000200703334062996 27 5380505 SGTC_1788 fluconazole 20 µM 3.50517097106196 0.00159440656483907 no 50 0.000228157072240852 75 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_526 4469-0568 170 µM 3.50398460554306 0.00159955377317434 no 51 0.000229175926904942 50 2901964 SGTC_2580 diallyl disulphide 81.36 µM 3.49920121626419 0.00162046113876288 no 52 0.000233327139048209 30 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_690 glyoxal 20.3 µM 3.47968281444226 0.00170837850899517 no 53 0.000251003868561534 106 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_706 4262-0057 46.9 µM 3.46639007290764 0.00177071588054242 no 54 0.000263748692882472 55 883298 SGTC_445 e6 berbamine 66 µM 3.4637159712487 0.00178350360191776 no 55 0.000266384362562712 146 6610268 A calcium/calmodulin antagonist. SGTC_1638 st008370 60.6 µM 3.45700274472356 0.00181597769580998 no 56 0.000273109642818315 47 24207134 SGTC_320 4092-0846 5.34 µM 3.42082445673961 0.00200042493885925 no 57 0.000312158079204233 72 1359356 SGTC_1660 st012960 28.1 µM 3.39902380044433 0.00211962458656965 no 58 0.000338134155746662 57 24207266 SGTC_3227 9130768 49.47 µM 3.33942106626878 0.00247910834751245 no 59 0.000419766029255913 14 17720899 SGTC_3324 9138759 60.749 µM 3.32215000159307 0.00259312039927323 no 60 0.000446633293436423 37 45595710 SGTC_3295 9122362 53.5725 µM 3.31240379804667 0.00265952957061427 no 61 0.000462489660945052 32 4730473 SGTC_1217 1183-1422 255 µM 3.29687595172195 0.00276851173872833 no 62 0.000488833356995357 32 2849664 SGTC_467 ro 31-8220 72.8 µM 3.29385238995171 0.00279019557303426 no 63 0.000494121903909462 116 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3060 1327-0027 12.5 µM 3.29133177682339 0.00280838944779494 no 64 0.000498571174693684 53 16000455 YPR107C YTH1 SGTC_1748 st037455 53.6035 µM 3.28589573747578 0.00284799177671883 no 65 0.00050829315510154 61 580690 SGTC_2280 7785178 200 µM 3.25171023225119 0.00310879172445672 no 66 0.000573564526776188 26 2954328 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 3.23334971995775 0.00325756621467175 no 67 0.000611738438371311 58 6708561 SGTC_1244 0416-0015 52.5 µM 3.21958980313035 0.0033732275465035 no 68 0.000641870723931342 72 96201 SGTC_847 0342-0274 5.54 µM 3.19948612161867 0.00354885226860965 no 69 0.000688364077109813 43 18097 SGTC_1875 nocodazole 6 µM 3.17993391768586 0.00372748975396313 no 70 0.000736543204273551 67 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_126 0417-1624 672.48 µM 3.15178809438765 0.00399880861873493 no 71 0.000811369962407784 68 41912 YDL195W SEC31 SGTC_1332 1480-0653 17.5 µM 3.14264534504958 0.00409067326471382 no 72 0.000837142831764838 39 5749438 SGTC_1787 fluconazole 80 µM 3.14242128366184 0.00409294811228432 no 73 0.000837783799432474 77 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3308 9128332 17.569 µM 3.13670083667222 0.00415141135062563 no 74 0.00085430185309267 130 17332805 YDL196W YDL196W SGTC_20 0481-0013 4.944 µM 3.13498661436808 0.00416907568667688 no 75 0.000859309766800109 64 182045 SGTC_1525 8-methoxypsoralen 92.5 µM 3.13131749518555 0.00420711056700072 no 76 0.000870119559131218 74 4114 Related to psoralen; DNA damaging agent. SGTC_1326 1431-2094 10.8 µM 3.12994922877266 0.00422137356674581 no 77 0.000874182590571777 64 616278 SGTC_1711 st032263 62.8 µM 3.12872884213821 0.00423413151727802 no 78 0.00087782120738853 44 3958979 SGTC_3200 9114385 49.47 µM 3.10393485324283 0.00450090441155686 no 79 0.00095482687432791 84 17018030 YLR208W SEC13 SGTC_720 r052-1644 49.9 µM 3.09841562595872 0.00456229335688987 no 80 0.000972791805970981 56 1422863 YOR257W CDC31 SGTC_3208 9114115 49.47 µM 3.08220960174037 0.00474689086611923 no 81 0.00102735051324845 81 650895 SGTC_1850 st056238 17 µM 3.08043698187688 0.00476748099967449 no 82 0.00103348545046654 56 5393177 SGTC_413 propylparaben 100 µM 3.07554004155776 0.00482477666548234 no 83 0.00105060856296476 57 7175 A pharmaceutical preservative. SGTC_2291 7917025 104.35 µM 3.06926375609897 0.0048991082431575 no 84 0.00107293523908186 94 2964612 SGTC_1720 st037298 9.481 µM 3.05829022602089 0.00503152537561781 no 85 0.00111301935386889 83 597396 SGTC_2686 alizarin 95.37 µM 3.05210723643681 0.005107530908728 no 86 0.00113620451073257 67 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_40 0327-0103 19.753 µM 3.03531434217838 0.00531914333716127 no 87 0.00120142554305858 73 409036 SGTC_1834 st055981 52.8 µM 3.03395266532851 0.00533663925395716 no 88 0.00120686149169265 72 471719 YDL150W RPC53 SGTC_149 3970-0822 46.1 µM 3.0338883450403 0.00533746695687933 no 89 0.00120711882059363 178 3114250 YBL034C STU1 SGTC_3244 9134489 49.47 µM 3.02955757626389 0.00539346054853368 no 90 0.00122456108351702 57 16584271 SGTC_2726 cimetidine 79.27 µM 3.00301140813263 0.00574823426524811 no 91 0.00133661205203005 22 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_578 3460-0051 92 µM 2.99204185308943 0.00590078316638317 no 92 0.0013855913413988 51 2876744 SGTC_2773 thioridazine 9.09 µM 2.96348294231132 0.00631490848567654 no 93 0.00152089460051921 47 5452 An antipsychotic. SGTC_2832 7992762 51.95 µM 2.96110630378432 0.0063505042933672 no 94 0.0015326805837607 73 2985177 SGTC_2218 6965428 192.983 µM 2.95541752668795 0.00643642948513659 no 95 0.00156123083459112 30 675684 SGTC_308 4092-1169 104 µM 2.91803949400375 0.00702702184741393 no 96 0.00176119866616591 107 2268590 YDL196W YDL196W SGTC_679 0422-0091 41.4 µM 2.90873149626784 0.00718133384991573 no 97 0.00181449194682104 91 627384 YHR062C RPP1 SGTC_177 1327-0068 8.361 µM 2.90507461219707 0.00724277231128076 no 98 0.00183582781591979 102 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2308 7584454 197.62 µM 2.88556072457901 0.00757851965433051 no 99 0.00195358539265454 85 893577 SGTC_2335 9018011 154.17 µM 2.87808198166506 0.00771078412070266 no 100 0.0020005057355655 82 6458208 SGTC_800 3448-7362 155 µM 2.85373081693306 0.00815562671733119 no 101 0.00216045631606635 298 15991913 SGTC_3076 9116187 49.47 µM 2.8501567408679 0.00822278007306541 no 102 0.00218488445207439 59 27241210 SGTC_1836 st055642 81 µM 2.84714436587945 0.00827975634422637 no 103 0.00220566761633916 86 8571 SGTC_350 k064-0020 19.8 µM 2.83427164989154 0.00852715650476838 no 104 0.00229651351007243 86 2790705 SGTC_1354 1498-1681 81 µM 2.8057760845788 0.00909799819537974 no 105 0.00250977799683844 83 5754243 SGTC_329 k048-0121 21.3 µM 2.79269336224161 0.00937110230661814 no 106 0.00261356081512992 65 6832902 SGTC_2909 7941780 10.49 µM 2.78881055022985 0.00945352473782265 no 107 0.00264510005263753 78 1243215 SGTC_2165 5727197 32.143 µM 2.77884077094428 0.00966806839587931 no 108 0.00272766295791736 114 1361712 SGTC_581 0958-0271 211 µM 2.77496026148059 0.00975271794075473 no 109 0.0027604226601044 137 4591145 SGTC_3294 9122953 26.2835 µM 2.76735237537086 0.00992055729869649 no 110 0.0028256816973637 89 16459826 SGTC_2129 girgensonine 121.053 µM 2.76387465100415 0.00999811640470049 no 111 0.00285597386564054 105 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_663 1486-0733 13.9 µM 2.7614435682583 0.0100526474617431 no 112 0.00287732302647113 126 722445 YPR165W RHO1 SGTC_3144 9087057 49.47 µM 2.75969491393282 0.0100920314483205 no 113 0.00289276814278428 73 17249618 SGTC_2033 5192550 145 µM 2.7570440581796 0.010151991974042 no 114 0.00291632460256556 67 182073 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.75397347264626 0.010221834792886 no 115 0.00294382700407685 96 5355888 SGTC_3246 9135460 32.98 µM 2.75317943443121 0.0102399638581317 no 116 0.00295097692707278 37 41446951 SGTC_1438 4092-1045 4 µM 2.74904589689116 0.0103347922750721 no 117 0.00298845082218066 56 1351342 SGTC_1287 0971-0001 34.6 µM 2.74426138811995 0.0104455099750473 no 118 0.00303236131163029 126 4665869 SGTC_1310 1188-0297 994 nM 2.74258987057576 0.0104844332791238 no 119 0.00304783834700512 95 1588352 SGTC_3161 9100388 49.47 µM 2.73117975220381 0.010753523507587 no 120 0.00315540204986283 49 25236368 SGTC_2204 7233102 200 µM 2.71563897760776 0.0111296902474162 no 121 0.00330740033267809 42 2172480 SGTC_1750 st081859 2.357 µM 2.71495047641216 0.0111466169953581 no 122 0.00331428409891349 296 5291695 SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.71363503079326 0.0111790193711169 no 123 0.00332747200376819 71 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1420 4'-methoxyflavone 42 µM 2.71204233995587 0.0112183604961096 no 124 0.00334350254112309 60 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_11 0438-0307 1.3 µM 2.71045853436895 0.0112576014444046 no 125 0.00335951246053501 64 4011476 SGTC_1279 0874-0590 65.2 µM 2.70661510185763 0.011353324165713 no 126 0.00339865072614902 100 3523074 SGTC_3236 9132701 49.47 µM 2.69369047776895 0.0116804255096047 no 127 0.00353328773348011 89 24282524 SGTC_1559 coumarin 343 70.1 µM 2.69364217244298 0.0116816632253934 no 128 0.00353379979226565 65 108770 A hepatotoxic, DNA x-linker. SGTC_1726 st035556 14.5795 µM 2.66083504585636 0.0125490116718156 no 129 0.00389735668134986 134 5919439 SGTC_1131 3454-3128 32.3 µM 2.6553098622371 0.0127004425105775 no 130 0.00396177940073739 132 710982 SGTC_582 0987-0078 156 µM 2.65161089464533 0.0128027029535639 no 131 0.00400544008183928 191 1625765 SGTC_2467 5474540 200 µM 2.65099533518163 0.0128197894546742 no 132 0.00401274749262817 97 5413519 SGTC_625 k213-0058 121 µM 2.65035091505273 0.01283769819164 no 133 0.00402041030027733 252 3655420 SGTC_21 0849-0113 22.993 µM 2.63868873602159 0.0131655548628206 no 134 0.0041613679093783 123 1560156 SGTC_1524 corynanthine 62.1 µM 2.61374929320747 0.0138910292140598 no 135 0.00447773619755213 101 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1415 3966-0071 78.1 µM 2.61131850700251 0.0139635490770941 no 136 0.00450969239823314 59 2893185 SGTC_791 1348-1292 225 µM 2.60700010808493 0.0140931889500219 no 137 0.00456696657329096 145 5437054 SGTC_3038 9091290 49.47 µM 2.60461699781159 0.0141651739136939 no 138 0.00459885061040787 91 25236843 SGTC_3182 9108849 49.47 µM 2.60141915854296 0.0142622664379855 no 139 0.00464194716276819 79 17133045 SGTC_547 1120-0019 610 nM 2.59343298614503 0.0145072487151195 no 140 0.00475115278114849 122 3676939 SGTC_2242 6630449 61.2675 µM 2.58456709911426 0.0147834511449426 no 141 0.00487506653716924 122 691249 YDR170C SEC7 SGTC_2630 antimycin a 100 µM 2.58030239443502 0.0149179143470055 no 142 0.00493569165948606 129 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2290 7904846 200 µM 2.57284931105579 0.0151554300688752 no 143 0.00504325566358701 130 2962154 SGTC_2610 ononetin 44.17 µM 2.57157012564306 0.0151965202817972 no 144 0.00506192549990027 157 259632 SGTC_820 1582-0060 59.9 µM 2.54364511187833 0.0161176773907386 no 145 0.00548512396478372 124 3848840 SGTC_2948 9070189 9.45 µM 2.53459017784194 0.0164264654630219 no 146 0.00562894733544637 115 6473636 YDL196W YDL196W SGTC_3148 9097893 49.47 µM 2.53315511001207 0.0164758656811871 no 147 0.00565204598233089 131 17174100 SGTC_886 0866-0150 153 µM 2.51694255639441 0.0170428520632281 no 148 0.00591890638155631 122 271463 SGTC_408 cantharidin 100 µM 2.5160982107212 0.0170728319999481 no 149 0.00593310558945036 113 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.49616825064117 0.0177936802813887 no 150 0.00627715193886801 127 521171 SGTC_1268 0828-0275 2.46 µM 2.4747816309933 0.0185959367535112 no 151 0.00666588311876294 124 745337 SGTC_1094 duloxetine 25.4 µM 2.47290006150666 0.0186679695040599 no 152 0.00670108077501439 126 60834 A selective serotonin reuptake inhibitor. SGTC_201 4262-0159 12.803 µM 2.47225116397117 0.0186928664789401 no 153 0.00671325743860824 118 1341029 SGTC_2067 5224629 34.075 µM 2.4690047140989 0.018817851435875 no 154 0.00677447167803919 124 2835000 SGTC_140 0062-0056 502.533 µM 2.46815711003815 0.0188506001282087 no 155 0.00679053485290608 128 3758964 SGTC_1772 st048439 82.2 µM 2.44012939563001 0.0199611378861545 no 156 0.00734100097015622 142 2927068 YDL195W SEC31 SGTC_3056 9094900 49.47 µM 2.43477884299808 0.0201793338766377 no 157 0.00745044696165249 135 25236784 SGTC_1188 1403-0014 4.57 µM 2.43046820005515 0.0203565902168415 no 158 0.00753966462344407 195 9614867 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.42594571267007 0.0205439745767781 no 159 0.00763427702439768 207 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_918 glabranin 770.725 nM 2.42589700690806 0.0205460005744004 no 160 0.00763530163391875 134 124049 Also referred to as licorice root. SGTC_1426 4048-4480 71.7 µM 2.4106308181027 0.0211894197077655 no 161 0.00796247956278556 118 14224343 SGTC_3116 9124943 49.47 µM 2.4008083663268 0.0216123502254303 no 162 0.00817945049163066 122 41905195 YPL160W CDC60 SGTC_1120 ficusin 1.78878 µM 2.38832334367453 0.0221602001312179 no 163 0.00846272159813444 129 6199 A DNA cross-linker. SGTC_3271 9137798 49.47 µM 2.38773946249825 0.0221861054633682 no 164 0.00847617742234858 78 6498326 SGTC_2768 sulfasalazine 50.2 µM 2.38676674003518 0.0222293194493848 no 165 0.00849863598093712 122 5384001 An antioxidant and salicylic acid derivative. SGTC_947 3447-0010 211 µM 2.38570777310258 0.0222764456413304 no 166 0.00852314513502015 120 748350 SGTC_802 4112-3352 742 µM 2.37741308189424 0.0226485001494207 no 167 0.00871727567134381 144 704594 SGTC_214 4373-3496 70 µM 2.37239029329437 0.0228763310885059 no 168 0.00883670536826984 230 3779166 SGTC_419 nsc-638432 893 µM 2.35700109028529 0.0235864309152598 no 169 0.00921159638381065 126 368090 SGTC_171 k064-0041 9.68 µM 2.35317117679188 0.0237660068328181 no 170 0.00930703147973545 113 53325 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.3329593943723 0.0247328370999694 no 171 0.00982513829334367 198 368090 SGTC_2910 7948405 25.97 µM 2.32935833474382 0.0249085109491061 no 172 0.00992004519790986 127 2971328 SGTC_1575 cyproterone acetate 48 µM 2.32190909294971 0.0252752366262235 no 173 0.0101189155485439 146 9880 An androgen receptor antagonist and liver toxin. SGTC_942 3253-1115 227 µM 2.31667137017577 0.0255357891490901 no 174 0.0102608201457345 151 46497897 SGTC_3178 9107506 49.47 µM 2.31380507369571 0.025679323839746 no 175 0.0103392084705137 138 8897194 SGTC_523 1934-0222 13.7 µM 2.31151811523207 0.0257943310381366 no 176 0.0104021268687725 152 1361595 SGTC_1661 st013063 9.66 µM 2.30864740151997 0.0259393041155811 no 177 0.0104815776510085 169 721395 SGTC_287 k060-0039 29.6 µM 2.30263643842001 0.026245070779382 no 178 0.0106496535903459 114 5861974 SGTC_2853 9015042 58.44 µM 2.30030863761329 0.0263642884171852 no 179 0.010715370334867 141 6457456 SGTC_949 1165-0505 146 µM 2.27578266981426 0.0276481092510616 no 180 0.0114295102460765 173 6244267 SGTC_2249 haloperidol 116.36 µM 2.27419489344802 0.0277329874337111 no 181 0.0114771355746082 311 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1460 k062-0059 9.15 µM 2.26903639971892 0.0280102463996928 no 182 0.0116330562145444 156 1373085 SGTC_655 k060-0012 42 µM 2.26877634175018 0.028024284911161 no 183 0.0116409651878928 137 5994525 SGTC_3336 9143619 71.43 µM 2.26776968770031 0.0280786816006225 no 184 0.0116716239254041 147 45595730 SGTC_1623 st003709 20.3 µM 2.26467307605225 0.0282465650602688 no 185 0.0117663744347193 258 16192618 SGTC_3206 9114350 49.47 µM 2.25773731049324 0.0286256220003827 no 186 0.0119810208222754 144 17087243 SGTC_466 geldanamycin 89.2 µM 2.2447486567679 0.0293468651614274 no 187 0.0123921362585286 90 5288382 HSP90 inhibitor. SGTC_1082 camptothecin 424.86 nM 2.23636317884294 0.0298204678545506 no 188 0.012663995518224 194 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1885 st057546 99.9 µM 2.21952677523364 0.0307905235599089 no 189 0.0132254538561727 177 702008 SGTC_921 1561-0023 372 µM 2.21358597087398 0.0311389877104731 no 190 0.0134286366347513 162 24050882 SGTC_3069 9117009 49.47 µM 2.21215212546904 0.0312235783815411 no 191 0.0134780777463605 77 41904981 SGTC_2161 5662504 8.5105 µM 2.20933462501648 0.031390352417856 no 192 0.0135756872657651 167 2859334 SGTC_512 prima-1 270 µM 2.20869580277707 0.0314282679605657 no 193 0.0135979032858759 148 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1290 0986-0249 10.2 µM 2.20092300838655 0.0318926413250634 no 194 0.0138707373935653 117 53329 SGTC_3276 9139060 49.47 µM 2.19872452140836 0.0320250098984575 no 195 0.0139487581272027 108 4870619 SGTC_1181 1222-0449 220 µM 2.19514704764957 0.0322413753054431 no 196 0.0140765256344851 169 658318 SGTC_3279 9140807 49.47 µM 2.19267615120295 0.0323915183003061 no 197 0.0141653600983622 138 45595718 SGTC_2974 9094440 9.66 µM 2.18924495765885 0.0326009696988812 no 198 0.0142895203033153 199 25236134 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.18515198393287 0.0328522779907581 no 199 0.0144388523891413 227 2724 A muscle relaxant with antifungal properties. SGTC_1545 lovastatin 49.4 µM 2.18486260423551 0.0328701061613929 no 200 0.014449461070901 210 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2881 9058953 51.95 µM 2.18387888076477 0.0329307712661674 no 201 0.0144855746403747 201 17122249 SGTC_3154 9100113 49.47 µM 2.18167728407221 0.0330668756255814 no 202 0.0145666792902032 182 25237525 SGTC_3274 9138298 49.47 µM 2.16295511372477 0.034243122662388 no 203 0.0152723160687505 166 17015756 SGTC_3119 9125183 49.47 µM 2.15989632681079 0.0344385251749028 no 204 0.0153903480964813 102 22695334 SGTC_919 tnp00227 403.569 nM 2.15834779367035 0.0345377978899713 no 205 0.0154504007176882 205 1269246 A methoxyflavone. YNL221C POP1 SGTC_1963 st076565 50.3 µM 2.15422252345265 0.0348034067307717 no 206 0.0156113626700053 142 4914280 SGTC_696 1560-0013 611 µM 2.15400102572305 0.0348177153510835 no 207 0.0156200457390681 179 1650269 SGTC_1047 2043-3044 82 µM 2.15361532497616 0.0348426429151496 no 208 0.0156351757229564 211 669592 SGTC_1775 st081588 35.1725 µM 2.15143674452457 0.0349837182599379 no 209 0.0157208717782133 201 1426443 YGL099W LSG1 SGTC_1472 k841-0093 193 µM 2.15141113397968 0.0349853794706936 no 210 0.0157218815790905 201 X1472 SGTC_29 0299-0004 12.984 µM 2.15118760044517 0.0349998815717432 no 211 0.0157306976688699 120 16871 A napthoquinone isolated from Swertia calycina. SGTC_67 0335-0847 266 µM 2.14748085707877 0.0352410826296607 no 212 0.015877509792214 340 4552207 YOR254C SEC63 SGTC_485 niflumic acid 177 µM 2.14100735504258 0.0356655883156476 no 213 0.0161367224687546 153 4488 A COX2 inhibitor. SGTC_2655 perillic acid 100 µM 2.13771447216211 0.0358831249535422 no 214 0.0162699620991056 106 5702197 An apoptosis inducer. SGTC_1908 st060353 56.5 µM 2.13643970757539 0.0359676306422479 no 215 0.0163217952159847 240 4227716 SGTC_1239 0337-0584 35.4 µM 2.13608410971998 0.0359912327124141 no 216 0.0163362793593078 247 914301 YML130C ERO1 SGTC_580 1123-0028 41 µM 2.13576067607092 0.0360127109651374 no 217 0.0163494629540964 249 1677248 YPR107C YTH1 SGTC_264 promethazine 12.5 mM 2.13322584739025 0.0361814050766825 no 218 0.0164531018817499 278 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2968 9090663 33.37 µM 2.13224996326151 0.0362465229055534 no 219 0.0164931515335767 204 25236811 SGTC_2002 4023503 131 µM 2.11856540782667 0.0371697994316294 no 220 0.0170636058741528 246 4736863 YCR052W RSC6 SGTC_1383 3049-0032 20.7 µM 2.1185205860331 0.0371728547739106 no 221 0.0170655016795065 196 712864 SGTC_2046 4110841 106 µM 2.11179622770916 0.0376335605995735 no 222 0.0173519655013966 173 44119630 YMR134W ERG29 SGTC_454 lyso-paf C-16 6.67 µM 2.10785945470895 0.0379054371167441 no 223 0.0175215741246962 191 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_227 fluconazole 33.516 µM 2.09504764175367 0.0388013440932014 no 224 0.0180833787984638 270 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2057 5236571 38.335 µM 2.09360118883877 0.0389035666681042 no 225 0.0181477607898128 253 54684039 YBR257W POP4 SGTC_630 4356-0227 183 µM 2.09157855658313 0.0390468761827214 no 226 0.0182381161998613 155 779312 SGTC_1375 2910-0797 186 µM 2.08299946810402 0.0396595149872227 no 227 0.0186256360212267 197 742508 SGTC_1150 3909-7983 10.9 µM 2.08024010689364 0.0398582162078698 no 228 0.0187517576237331 225 23965914 SGTC_786 4544-0069 423 µM 2.07681333979437 0.0401061029071366 no 229 0.0189093952635995 225 748821 YLR208W SEC13 SGTC_785 1270-0111 65.3 µM 2.0645036380115 0.0410069158272219 no 230 0.0194849946609752 234 6741994 SGTC_349 k015-0014 24 µM 2.05560630227753 0.0416681773732538 no 231 0.0199102399195405 197 2196908 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.04775402225027 0.0422589198981494 no 232 0.0202920537694027 227 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2461 5755302 26.15 µM 2.03775455117397 0.0430209892094715 no 233 0.0207872428277677 241 2788904 SGTC_3250 9135583 49.47 µM 2.02728740992976 0.0438305548728713 no 234 0.0213165141602849 161 7699353 SGTC_2731 amoxapine 43.43 µM 2.01804182926448 0.044555821368668 no 235 0.0217934525618068 79 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2137 5261020 140 µM 2.01463562770581 0.0448254444258243 no 236 0.0219714207919111 229 763655 SGTC_1497 4476-2978 41.3 µM 2.01273122764337 0.0449767617235655 no 237 0.0220714561560735 258 1528379 SGTC_2917 7979103 53.79 µM 2.0119278910005 0.04504071536008 no 238 0.0221137694061975 264 2980565 SGTC_1797 st048695 56.8 µM 2.01079410413666 0.0451311006594722 no 239 0.0221736045761581 231 592262 YIL048W NEO1 SGTC_2020 4017018 200 µM 2.00881769619872 0.04528900849623 no 240 0.0222782354204447 212 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_631 k072-0230 41.5 µM 2.00662978988884 0.0454643323128951 no 241 0.0223945484514573 218 5773147 SGTC_2733 amorolfine 100 µM 2.00646234407184 0.0454777727268207 no 242 0.0224034712329921 99 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_246 cycloheximide 667 µM 2.00228131922527 0.0458144092327697 no 243 0.0226272419894141 164 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_258 haloperidol 50.781 µM 1.99389846358163 0.0464953891721806 no 244 0.0230815759509465 266 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1762 st045503 25.4615 µM 1.99288593878437 0.0465781885350257 no 245 0.0231369691956607 231 4645554 SGTC_1228 0124-0032 52.5 µM 1.9923064439798 0.0466256300227504 no 246 0.0231687225514779 231 X1228 SGTC_1832 st054113 55 µM 1.98710659032599 0.047053063341226 no 247 0.0234552930427727 172 1251267 SGTC_178 4092-0806 87.505 µM 1.9849462662098 0.0472315654691005 no 248 0.0235752250643803 357 2169044 SGTC_1443 4112-3303 14 µM 1.98312988140022 0.04738206843139 no 249 0.0236764618077332 225 704433 SGTC_604 1000-0114 314 µM 1.98228766146569 0.0474519838134349 no 250 0.0237235270937627 229 1572745 SGTC_1114 scopoletin 1.73284 µM 1.97559222487989 0.0480107381975719 no 251 0.0241004899776009 194 5280460 A coumarin with genotoxic properties. SGTC_2171 5739187 198.077 µM 1.97390223736192 0.0481526018983315 no 252 0.0241964301622324 180 2262761 SGTC_965 1291-5240 308 µM 1.95241759820378 0.0499854913524063 no 253 0.0254443226841574 257 2834598 SGTC_1487 3970-0795 2.82 µM 1.95193867220389 0.0500269745637974 no 254 0.0254727431028421 226 3765103 SGTC_2754 granisetron 64.02 µM 1.94649231814262 0.0505006559066905 no 255 0.0257978149050006 259 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1311 1190-0148 100 µM 1.94556560144393 0.0505816090641263 no 256 0.0258534711960643 277 1961333 SGTC_1627 st003713 25.6 µM 1.94388034216879 0.0507290894473423 no 257 0.0259549411547268 361 16195070 YER133W GLC7 SGTC_491 tetrandrine 80.3 µM 1.94309662265452 0.050797790850813 no 258 0.0260022425120516 169 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_860 0443-0016 25.1 µM 1.93476990077663 0.0515323007465636 no 259 0.0265092691119952 233 5337942 SGTC_352 k048-0007 5.11 µM 1.91301418874995 0.0534912905249078 no 260 0.0278731180227913 303 6811911 SGTC_3238 9133470 49.47 µM 1.9103957213053 0.0537309963271898 no 261 0.0280411406722381 201 3534688 SGTC_1899 st063254 59.6 µM 1.90881349299739 0.0538762521757296 no 262 0.0281430778091955 205 3093813 SGTC_2116 5511452 16.8835 µM 1.89205313404455 0.0554340903905585 no 263 0.0292419508615436 255 870744 SGTC_2695 st077686 51.995 µM 1.88612139874193 0.0559938768245848 no 264 0.0296392986596311 248 2876092 SGTC_931 2812-0076 566 µM 1.88284402731989 0.0563050739993999 no 265 0.0298607542435097 262 3450959 SGTC_1948 st076329 66.6 µM 1.88257384231362 0.0563307896654521 no 266 0.0298790720192565 240 24208413 SGTC_970 1315-0089 19.5 µM 1.87834118235417 0.0567348554822452 no 267 0.0301672531009774 230 6811083 YLR033W RSC58 SGTC_302 1094-0063 18.9 µM 1.87694923931178 0.056868233384597 no 268 0.0302625256598033 191 5440289 SGTC_1534 6-azauridine 81.6 µM 1.87265934911384 0.0572808502435127 no 269 0.0305577200948604 297 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_9 0092-0002 10.449 µM 1.87112417430465 0.0574290799021196 no 270 0.0306639357876906 262 759368 SGTC_2086 5274770 176.623 µM 1.87084793475752 0.0574557843732995 no 271 0.0306830806708174 266 689278 SGTC_2406 ethylparaben 405.7 µM 1.86803403093325 0.0577283653628066 no 272 0.0308786638103572 252 8434 A possible steroid mimic. SGTC_2216 7189485 200 µM 1.8638716055992 0.0581334400412834 no 273 0.0311698685215598 185 731273 SGTC_2414 st077232 92.9 µM 1.85942083953491 0.0585690424046214 no 274 0.0314837550928131 272 729801 SGTC_632 0781-2353 4.65 µM 1.85362856764056 0.0591397725488808 no 275 0.0318961588141126 299 6811515 YHR007C ERG11 SGTC_2106 5357045 167.29 µM 1.84683611906327 0.0598145997399238 no 276 0.0323854476756626 270 668842 SGTC_828 2074-0507 139 µM 1.84111713515305 0.0603874433383553 no 277 0.0328021975698229 293 X828 SGTC_47 0149-0135 24.25 µM 1.84028679233867 0.0604709705946278 no 278 0.0328630717017037 252 5239155 SGTC_2762 leflunomide 42.06 µM 1.83872019762105 0.0606288062968881 no 279 0.0329781755477033 294 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_159 3970-0959 50 µM 1.83655997591922 0.0608469787415422 no 280 0.0331374402352765 498 6615653 SGTC_2973 9094665 17.96 µM 1.83607730818658 0.0608958097638684 no 281 0.033173111908441 324 25237061 YIL048W NEO1 SGTC_997 3996-0078 137 µM 1.83518574698524 0.0609860887012024 no 282 0.0332390861296202 296 735687 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.83111672826868 0.0613994440778325 no 283 0.0335415610943961 286 16486 A toxic proline analog. SGTC_561 1550-0330 72.9 µM 1.82882584950531 0.0616331263980853 no 284 0.0337128506245867 256 6812934 SGTC_1468 k284-1086 134 µM 1.82493541971363 0.0620315621659192 no 285 0.0340053877055514 349 15996457 SGTC_1456 k015-0012 13 µM 1.82240984200195 0.0622912914890295 no 286 0.0341964111688311 325 2989616 SGTC_1021 4476-0760 85.3 µM 1.81645615431431 0.0629069223219695 no 287 0.0346502139711685 288 746768 SGTC_3343 9148379 18.9835 µM 1.81049819978126 0.0635277292726341 no 288 0.0351092816364234 259 1955036 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.80266391995755 0.0643512894874787 no 289 0.0357205058941001 285 3256 An antibiotic and ribosome inhibitor. SGTC_1930 st074634 34.3 µM 1.80246318063713 0.0643725002369125 no 290 0.0357362812812026 301 684253 YOR116C RPO31 SGTC_2721 ifenprodil 61.44 µM 1.80203400095069 0.0644178669388723 no 291 0.0357700281343635 278 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_598 3937-0236 20.2 µM 1.80026933809853 0.0646046628159762 no 292 0.0359090599813886 322 1379313 SGTC_952 1185-0122 232 µM 1.79953337992024 0.0646826908335306 no 293 0.0359671743162253 294 678600 SGTC_770 0389-1121 67.2 µM 1.79801850955863 0.0648435313072933 no 294 0.0360870373103931 341 6753108 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.78889251126653 0.0658190571795694 no 295 0.0368160640409161 313 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1267 0828-0272 9.49 µM 1.78498975072086 0.0662397002393213 no 296 0.0371314896824879 300 745334 SGTC_2803 7707263 71.43 µM 1.78432092537471 0.0663119953590098 no 297 0.0371857659532406 267 2199229 SGTC_913 3487-1245 167 µM 1.77260473740289 0.0675883630515996 no 298 0.0381471130899082 318 4016153 SGTC_2525 harmine 47.85 µM 1.75622430867103 0.0694045730371973 no 299 0.0395250577867981 218 5280953 A monoamine oxidase inhibitor SGTC_31 0508-1974 57.237 µM 1.75603223918929 0.0694260898809727 no 300 0.0395414519505607 281 6810525 SGTC_1985 st071382 65.5 µM 1.75340047245214 0.0697214348445016 no 301 0.03976664498943 283 6123237 SGTC_35 0133-0054 64.071 µM 1.74341293192145 0.0708510729596746 no 302 0.0406307554996673 299 99677 SGTC_1020 4335-0961 93.3 µM 1.7371533275433 0.0715661991150749 no 303 0.0411800552888618 288 669075 SGTC_2489 cantharidin 73.42 µM 1.73590660221696 0.071709289894711 no 304 0.0412901751139292 367 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1482 3346-2049 8.48 µM 1.73255296760367 0.0720952867861514 no 305 0.0415875774622026 291 3826804 SGTC_3054 9094397 49.47 µM 1.72980568239285 0.0724126792117347 no 306 0.0418324994332152 346 2598354 SGTC_2315 7733312 200 µM 1.72894986791374 0.0725117693838578 no 307 0.0419090339168395 280 726316 SGTC_2398 5228213 48.84 µM 1.72148363777111 0.0733806548828833 no 308 0.0425815493899538 399 80771 YMR134W ERG29 SGTC_294 k038-0071 157 µM 1.72066372607402 0.0734765556577602 no 309 0.0426559311581323 361 24152826 SGTC_94 0334-0113 514.748 µM 1.72050612564234 0.0734950003316755 no 310 0.0426702405792788 322 6795178 SGTC_1147 3809-1045 12.3 µM 1.71892405913573 0.0736803527748095 no 311 0.0428141003281024 317 325925 SGTC_2344 7990960 76.95 µM 1.71658707644899 0.0739548035457502 no 312 0.0430273227257785 305 140813 SGTC_1298 1079-1278 263 µM 1.71559883465067 0.0740710954967483 no 313 0.0431177459765236 320 2840950 SGTC_2907 7721985 69.9 µM 1.71305236346161 0.0743713967734178 no 314 0.0433514533268911 327 3267881 SGTC_378 3970-0959 8.33 µM 1.71248680672404 0.0744382179586513 no 315 0.0434034969508397 307 6615653 SGTC_2070 5230947 200 µM 1.71198841826407 0.0744971411187304 no 316 0.0434494014199709 311 2835538 SGTC_403 arphamenine a 50 µM 1.71142777880998 0.074563466596875 no 317 0.0435010863990556 324 5487158 An arginine aminopeptidase inhibitor. SGTC_3167 9103034 49.47 µM 1.70523185581812 0.0752994689551196 no 318 0.044075595492596 229 5127859 SGTC_2104 5389443 200 µM 1.70264413921718 0.0756084935154394 no 319 0.044317342267291 362 2244536 SGTC_978 1416-0512 87.4 µM 1.70205606799115 0.0756788554110954 no 320 0.044372429150293 364 6814003 SGTC_1669 st015249 58.4 µM 1.70057961493337 0.0758557307706143 no 321 0.0445109773597539 262 722793 SGTC_1654 st012436 41.8 µM 1.69892984211004 0.0760537416366657 no 322 0.0446662017093321 278 4323132 SGTC_1684 st024538 14.6195 µM 1.69892405442372 0.0760544369847764 no 323 0.0446667470294375 319 6732859 SGTC_831 k061-1017 217 µM 1.69841316790425 0.0761158353288567 no 324 0.0447149042675966 492 1240153 SGTC_1519 esterone 74 µM 1.69759284337769 0.0762145008558829 no 325 0.0447923172456827 332 698 A steroid. SGTC_675 1309-0189 238 µM 1.69717836847375 0.0762643893286373 no 326 0.0448314717300861 317 4246530 SGTC_2553 4-methylesculetin 85.09 µM 1.69707644834061 0.0762766608009874 no 327 0.0448411041091803 336 5319502 SGTC_1926 methyl fluorone black 53.6 µM 1.69495051768301 0.0765329715626648 no 328 0.0450424040210595 328 72721 Reacts with homocysteine. SGTC_2702 st077768 96.8 µM 1.6946360321487 0.0765709427654998 no 329 0.0450722436527186 312 6484119 SGTC_3301 9125354 19.7965 µM 1.69190721867883 0.0769010234413856 no 330 0.0453318327055793 279 41905162 SGTC_1495 4469-0029 237 µM 1.68621748896277 0.0775927376491865 no 331 0.0458769582762571 479 793680 SGTC_1032 k061-1018 98.7 µM 1.68583247293044 0.0776397150811242 no 332 0.0459140356286586 384 4005393 SGTC_1761 st044296 37 µM 1.68500494847561 0.0777407579113952 no 333 0.0459938083863292 335 1826700 SGTC_1776 st049249 45.9 µM 1.68315750625949 0.0779666954121255 no 334 0.0461723022660343 364 1822314 SGTC_2450 5739737 12.93 µM 1.67797088292532 0.0786036691355809 no 335 0.0466763916794786 325 2262825 SGTC_914 3820-6779 408 µM 1.67568609480813 0.0788855142170058 no 336 0.0468998474593728 332 2893481 SGTC_681 1642-0006 26.6 µM 1.67022663971548 0.0795620768851289 no 337 0.0474372656050002 258 4446530 SGTC_315 k915-0449 187 µM 1.66540768634648 0.0801629055411787 no 338 0.0479157234870041 413 20970215 YNL149C PGA2 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.66424448752168 0.0803084460727431 no 339 0.0480317904989236 388 165506 SGTC_1484 3473-2379 286 µM 1.6564943675945 0.0812832499677884 no 340 0.0488108723733212 395 671917 SGTC_1769 st044406 64.4 µM 1.65182561285955 0.0818747753144669 no 341 0.0492850528824321 363 670903 SGTC_3239 9133757 49.47 µM 1.64747792943133 0.0824285331464543 no 342 0.049729924515928 279 17036923 SGTC_3299 9121982 43.1275 µM 1.64669695779605 0.08252830238201 no 343 0.0498101749216384 360 17594604 YPL160W CDC60 SGTC_1455 4262-0120 131 µM 1.64030964979137 0.0833476964740946 no 344 0.0504704001155979 357 1529587 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.63368060224152 0.0842045535255236 no 345 0.0511629667361181 400 676296 Flavone; oxidizing agent. SGTC_340 k038-0059 454 µM 1.63263374836115 0.0843404700657509 no 346 0.0512730244614771 378 23733424 SGTC_2153 5569715 200 µM 1.62855189065395 0.0848720039756917 no 347 0.0517039578947698 320 2054701 SGTC_2774 tamoxifen 10.92 µM 1.62623230058091 0.0851751747978673 no 348 0.0519501236415129 347 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1347 1493-0251 600 nM 1.62524324524498 0.0853046909953969 no 349 0.0520553696094113 366 3986378 SGTC_1342 1486-1464 234 µM 1.62087175254834 0.0858789028761337 no 350 0.0525225730303466 364 3253938 SGTC_3081 9117243 49.47 µM 1.61990377097068 0.0860064411621826 no 351 0.0526264748422411 334 45595589 SGTC_2732 terfenadine 20 µM 1.61990064844517 0.0860068528057715 no 352 0.0526268102735838 285 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3248 9135562 49.47 µM 1.61939158751427 0.0860739821923888 no 353 0.0526815178619637 374 17650701 SGTC_401 neomycin 50 µM 1.61666077696806 0.0864347609130939 no 354 0.0529757624500737 312 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2296 7971656 126.45 µM 1.61554069694479 0.0865830658833212 no 355 0.0530968272775194 393 666570 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.61416042400218 0.0867660833953967 no 356 0.0532463168993435 437 91467 include heat shock SGTC_2255 7941087 197.44 µM 1.61334819650025 0.0868739158536254 no 357 0.0533344405103764 405 935561 SGTC_3089 9117425 49.47 µM 1.60989494777929 0.087333491905122 no 358 0.0537103960684379 365 9401657 SGTC_4 0960-0234 25.671 µM 1.60292593004598 0.0882664878387089 no 359 0.0544755040545312 347 6821112 SGTC_331 k048-0133 24.5 µM 1.60183271247966 0.0884135168412676 no 360 0.0545963035758494 309 6813582 SGTC_767 0929-0023 86 µM 1.60099634523 0.0885261246896362 no 361 0.0546888643157188 487 1204563 SGTC_1493 4348-0038 111 µM 1.60082936069595 0.0885486201500823 no 362 0.0547073593390149 401 800424 SGTC_2434 5670830 169.91 µM 1.59999610090027 0.0886609370825994 no 363 0.0547997241923034 389 1549830 SGTC_3317 9138495 8.753 µM 1.59924144782657 0.0887627499760271 no 364 0.054883482011572 386 17020139 SGTC_1467 k284-1082 293 µM 1.59728501905549 0.0890271040422139 no 365 0.0551010943177933 370 3334705 SGTC_1440 4100-1550 40 µM 1.59658720302543 0.0891215350943723 no 366 0.0551788766667014 297 742806 SGTC_2444 5485484 36.41 µM 1.59601103527281 0.0891995604169311 no 367 0.0552431647898875 390 6790631 SGTC_1956 st077085 54 µM 1.59281473048437 0.0896333311600149 no 368 0.0556008797865544 414 24208685 SGTC_849 0386-0493 241 µM 1.59170019292663 0.0897849533455936 no 369 0.0557260424858741 353 726119 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.59118977499839 0.089854454443598 no 370 0.0557834366582846 407 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1873 rapamycin 2 nM 1.5886809349099 0.0901966522486055 no 371 0.0560662226674384 437 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1433 4060-0023 7.6 µM 1.58634701318602 0.090515860032074 no 372 0.0563303065468926 369 3840627 SGTC_3104 9120930 49.47 µM 1.58510341127211 0.0906862881577768 no 373 0.0564714203328064 318 17014836 SGTC_2474 5321570 43.32 µM 1.58468423918971 0.0907437867913203 no 374 0.056519047283531 343 2841384 SGTC_999 SEC7.066 22.7 µM 1.58356385356738 0.0908976050143897 no 375 0.0566465025254591 420 740511 YDR170C SEC7 SGTC_202 3594-0513 34.79 µM 1.58328557512553 0.0909358399541192 no 376 0.0566781946039723 311 708429 SGTC_2802 7925815 54.55 µM 1.58103452475286 0.0912455688036282 no 377 0.0569350719686925 411 1262923 SGTC_676 falcarinol 140 µM 1.57873527016323 0.0915627370200033 no 378 0.0571983956254544 413 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2389 9091542 195.52 µM 1.57756699480435 0.0917242062022524 no 379 0.0573325598949821 421 3626624 YOL127W RPL25 SGTC_273 hydroxyurea 18.1 mM 1.57573931831846 0.0919772352661272 no 380 0.0575429460856114 445 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3109 9122853 49.47 µM 1.57502975405534 0.0920756086552684 no 381 0.0576247883956213 366 1234709 SGTC_778 3456-2434 196 µM 1.57485189640267 0.0921002788956707 no 382 0.0576453171322948 486 5539063 SGTC_1170 0310-0127 64.8 µM 1.57282609105939 0.0923816192534584 no 383 0.0578795462404694 399 774975 SGTC_1165 k072-0275 30.3 µM 1.57084989111572 0.0926566828075534 no 384 0.0581087600949771 360 6153523 YGL055W OLE1 SGTC_1719 st032227 49.2 µM 1.56227207548166 0.0938576358961929 no 385 0.0591119537444011 392 3125804 SGTC_1074 carmofur 3.8 µM 1.56103369951759 0.0940319618266745 no 386 0.0592578999037339 446 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1911 st060208 74.3 µM 1.54642417552591 0.0961066048705386 no 387 0.061001079641325 429 688783 SGTC_1506 4226-2149 212 µM 1.5447701271946 0.0963435943454783 no 388 0.0612009377072011 452 991114 SGTC_2415 st077333 57.7 µM 1.53940087096963 0.0971158525939294 no 389 0.0618532307748291 477 2766255 SGTC_2384 9036245 200 µM 1.53803518272873 0.0973130018250298 no 390 0.062020006304799 413 6462766 SGTC_2958 9077254 16.72 µM 1.53771263969324 0.0973596066116401 no 391 0.0620594458879319 372 16457351 SGTC_3181 9108277 49.47 µM 1.53569018439414 0.0976522078572089 no 392 0.0623071917895892 382 17097298 SGTC_2349 9023730 187.07 µM 1.52820162859659 0.0987412377623239 no 393 0.0632312422898804 415 4126287 SGTC_832 4083-0019 164 µM 1.5280170752653 0.0987681883669114 no 394 0.063254149251224 607 1990758 SGTC_2845 9003024 42.97 µM 1.52657051605745 0.0989796180942873 no 395 0.0634339216265725 433 2990173 SGTC_1377 2944-0135 198 µM 1.52126126983798 0.0997584574378433 no 396 0.0640971426774764 438 1894137 SGTC_92 0063-0024 660.874 µM 1.52076394249412 0.0998316415140133 no 397 0.064159542988214 445 3594437 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.51719321929261 0.100358242230638 no 398 0.064608953894679 286 279621 SGTC_2446 5162541 200 µM 1.51408239578618 0.100818668038752 no 399 0.0650024714858358 397 1549321 SGTC_2248 tofa 1.1 µM 1.51402057087886 0.100827834185007 no 400 0.0650103111173637 377 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1466 k213-0079 57.5 µM 1.51303399485258 0.100974185941855 no 401 0.0651355119977305 430 3657981 SGTC_1336 1486-0901 104 µM 1.512782154581 0.101011569509626 no 402 0.0651675016054901 408 5006114 SGTC_1045 1348-1485 165 µM 1.51159889756743 0.101187349113489 no 403 0.0653179661609307 474 6810614 SGTC_1734 st037168 69.4 µM 1.50324666101274 0.102434464818776 no 404 0.0663877245315102 423 708907 SGTC_1223 0764-0573 147 µM 1.4996470138735 0.102975379415804 no 405 0.0668529312877946 469 1609797 SGTC_3292 9120825 59.784 µM 1.49868491013457 0.103120304356038 no 406 0.0669776966044215 410 24824900 SGTC_2062 5245942 200 µM 1.49854309058488 0.103141679635207 no 407 0.0669961029409061 445 1376160 SGTC_976 1348-1067 47.6 µM 1.49761025514036 0.103282358344681 no 408 0.0671172703900182 482 5310671 YGL099W LSG1 SGTC_1666 st014829 29 µM 1.49371856716948 0.10387075757683 no 409 0.0676245967477845 453 3858230 SGTC_3031 9088762 49.47 µM 1.49286770793419 0.10399972550603 no 410 0.0677359097430673 430 205253 SGTC_1067 clotrimazole 1.36 µM 1.49114193021089 0.104261664635869 no 411 0.0679621178744579 454 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_773 4358-1457 44.6 µM 1.49022298105985 0.104401337997036 no 412 0.0680828078664288 491 1186886 SGTC_887 0885-0007 9.62 µM 1.48986527443911 0.104455743358526 no 413 0.0681298319025231 457 5719458 SGTC_2855 9016525 58.44 µM 1.48534112732902 0.105145616779335 no 414 0.0687267412254822 413 43811474 SGTC_741 4582-0002 126 µM 1.4799012747278 0.10597948176216 no 415 0.0694497977324685 438 2912688 SGTC_1264 0783-0040 158 µM 1.47242210667094 0.107133736200133 no 416 0.0704534635449545 404 2855798 SGTC_1182 1222-0449 220 µM 1.4714393048319 0.107286082625777 no 417 0.0705861752340844 418 658318 SGTC_3043 9092303 49.47 µM 1.47135857326276 0.107298603954703 no 418 0.0705970852770528 396 25236084 SGTC_2888 9058547 12.99 µM 1.47053697267774 0.107426092729648 no 419 0.0707081898875929 352 16476514 SGTC_1462 k081-0014 26.5 µM 1.46812240043118 0.107801396728698 no 420 0.0710354889481591 300 3270634 SGTC_125 0133-0007 11.75 µM 1.46602300451185 0.108128478739331 no 421 0.0713210099094854 440 26541 SGTC_1851 st056236 18.9 µM 1.45993410444607 0.109081157430979 no 422 0.0721540925404622 439 5393171 SGTC_1513 0337-0559 19 µM 1.457086865551 0.109528704843708 no 423 0.0725462017610981 386 775073 SGTC_2366 9070441 60.58 µM 1.45603001817165 0.109695162051617 no 424 0.0726921607751696 463 6837235 SGTC_1362 1611-0397 101 µM 1.45292031169168 0.110186005017811 no 425 0.0731229403512388 450 27816 SGTC_402 epigallocatechin gallate 10 µM 1.44308712611518 0.111748458391665 no 426 0.074497964713111 475 65064 An antioxidant. SGTC_506 n9-isopropylolomoucine 153 µM 1.44188963465289 0.111939812064726 no 427 0.074666755393091 439 6610355 SGTC_1419 3993-2473 62.6 µM 1.44174028286609 0.1119636942223 no 428 0.0746878275120135 454 704026 SGTC_1052 3253-3998 198 µM 1.44159942260551 0.111986221877133 no 429 0.0747077057154105 512 5450317 SGTC_2566 crystal violet carbinol 226 nM 1.4405963565966 0.112146735034039 no 430 0.0748493751680138 417 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2885 9057732 51.95 µM 1.43923779751497 0.112364397196094 no 431 0.0750415798532664 447 6471414 SGTC_2336 9001819 198.65 µM 1.43779099834409 0.112596528498684 no 432 0.0752466821063981 490 2989602 SGTC_317 4495-0002 170 µM 1.43537241604875 0.112985341765852 no 433 0.075590500999245 406 15991618 SGTC_3080 9117754 49.47 µM 1.43469292159681 0.113094750078635 no 434 0.0756873110845141 484 9550191 SGTC_1199 1638-0010 4.46 µM 1.43402076742634 0.113203050860971 no 435 0.0757831682709519 497 3111136 SGTC_1089 terbinafine 2.25 µM 1.43093871326188 0.113700594050247 no 436 0.0762238903057321 435 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_481 bay k-8644 50 µM 1.4304847559292 0.113774008943571 no 437 0.0762889689633035 442 2303 A calcium channel antagonist. SGTC_516 3992-2719 87.3 µM 1.43001570739934 0.113849899898073 no 438 0.0763562554787712 414 5350887 YDR037W KRS1 SGTC_665 3914-0008 307 µM 1.42988857706599 0.113870475500986 no 439 0.0763745005086966 457 1069549 SGTC_2235 salicylic acid 500 µM 1.42933365119366 0.113960319353602 no 440 0.0764541791891703 410 338 A COX inhibitor and kinase inhibitor. SGTC_1073 triclabendazole 3.09 µM 1.4263856309656 0.114438457900313 no 441 0.0768785295261614 538 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2618 avocadyne 43.43 µM 1.41937121538783 0.115581861002978 no 442 0.0778954098794353 427 3015189 SGTC_643 k048-0106 28.4 µM 1.41763792511349 0.11586564680071 no 443 0.0781482508609231 463 6763920 SGTC_2219 9098279 200 µM 1.41758254702277 0.115874721818749 no 444 0.0781563393028296 455 902349 SGTC_2485 5633444 17.78 µM 1.41388876254472 0.116481176270078 no 445 0.0786972829617252 469 5724239 SGTC_711 k292-0785 179 µM 1.41379347839414 0.116496849982538 no 446 0.0787112744840259 476 4146315 SGTC_1729 st035615 45.989 µM 1.41326192923036 0.116584314311021 no 447 0.0787893617415298 467 17385451 SGTC_2805 7950783 58.44 µM 1.41272530305433 0.116672661270216 no 448 0.0788682543638839 534 1178958 YDL195W SEC31 SGTC_18 0111-0177 500 nM 1.41264602861524 0.116685716568203 no 449 0.0788799140448227 584 721752 SGTC_2957 9076800 11.52 µM 1.4123377927274 0.116736488188138 no 450 0.0789252617753284 430 16459615 SGTC_2658 polymyxin b sulfate 77.05 µM 1.4110389696751 0.116950598166929 no 451 0.0791165618530574 499 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2376 9072922 81.32 µM 1.40745967643041 0.117542081754072 no 452 0.0796455631100786 514 17087968 SGTC_2087 5276107 200 µM 1.40551357866825 0.117864564664057 no 453 0.0799343072027658 449 144405 SGTC_1065 prochlorperazine maleate 2.48 µM 1.40161171619515 0.118513017007456 no 454 0.0805156132076832 497 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1781 st038725 66.3 µM 1.39398423787862 0.119787903789643 no 455 0.0816611822359601 592 4270275 YIL048W NEO1 SGTC_1768 st044301 37.178 µM 1.38718635363479 0.12093225240436 no 456 0.0826924727615301 507 3931349 SGTC_2729 fluphenazine 10.66 µM 1.38671385317568 0.121012077590945 no 457 0.0827645173274991 505 3372 An atypical antipsychotic. SGTC_212 3807-4682 38.772 µM 1.38134286702037 0.121922069273001 no 458 0.0835867818350981 650 3125501 YBL034C STU1 SGTC_205 1486-1330 71.903 µM 1.38002307990003 0.12214641101571 no 459 0.0837897693605301 422 4118834 SGTC_410 α-linolenic acid 100 µM 1.37687368317551 0.122682926390632 no 460 0.084275652463435 524 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2059 5238311 157 µM 1.37546990529081 0.122922598763365 no 461 0.0844929047973002 474 703021 SGTC_2641 levomentholum 100 µM 1.36913969288869 0.124007457563287 no 462 0.0854778064390248 433 16666 SGTC_312 4092-0653 6.84 µM 1.36828825336083 0.124153885141306 no 463 0.0856109330985474 597 1148278 SGTC_2110 5483698 200 µM 1.36791744868169 0.124217692622422 no 464 0.0856689586942811 477 2848765 YHR062C RPP1 SGTC_2995 9067767 71.4286 µM 1.36509424123119 0.12470425792337 no 465 0.0861117159011642 438 11673567 SGTC_1364 1653-0028 37.6 µM 1.36431505250465 0.124838781331242 no 466 0.0862342152098081 523 5718652 SGTC_370 0180-0345 38.7 µM 1.36397210949904 0.124898021012446 no 467 0.0862881719104633 449 3989527 SGTC_815 1582-0027 36.9 µM 1.36233702143148 0.125180734760451 no 468 0.08654577457131 508 3128206 SGTC_326 k292-0812 17.5 µM 1.3620526092844 0.125229956430875 no 469 0.08659064139016 477 3579357 SGTC_1515 3460-0031 42.1 µM 1.3570538898257 0.126097264259187 no 470 0.0873820440431678 426 2876596 SGTC_726 3448-4391 34.2 µM 1.35645270110516 0.126201855524393 no 471 0.0874775874459089 552 1356692 SGTC_3112 9123419 49.47 µM 1.3555009063434 0.126367566777103 no 472 0.0876290100117153 541 17015854 SGTC_2403 6032726 181.2 µM 1.35395703130797 0.126636683868329 no 473 0.0878750433509191 501 2881040 SGTC_845 0330-0138 4.51 µM 1.3513327694939 0.127095041493971 no 474 0.0882944296765609 506 9039800 SGTC_533 1222-0222 6.71 µM 1.347274812877 0.127806081022371 no 475 0.0889458704594622 565 3982874 SGTC_1959 st077091 55.8 µM 1.34714838337208 0.127828278456369 no 476 0.0889662240391359 536 821356 YKL052C ASK1 SGTC_2918 7977171 22.06 µM 1.34562934434922 0.128095188097421 no 477 0.0892110415919344 485 2236483 SGTC_1846 st056244 14.8 µM 1.34451198439869 0.128291765833565 no 478 0.0893914418354568 547 5393182 SGTC_1314 1222-0010 41.1 µM 1.34446926863519 0.128299284995496 no 479 0.0893983437715489 494 3526027 SGTC_3323 9138564 53.9225 µM 1.34238660038873 0.128666263721647 no 480 0.0897353385601109 568 43912313 YNL103W MET4 SGTC_613 3914-0030 117 µM 1.34073262992317 0.128958221739898 no 481 0.0900036382164379 249 1145395 SGTC_139 0099-0334 718.624 µM 1.33973976272622 0.129133702666028 no 482 0.0901649827251304 605 97690 SGTC_1248 0469-0687 58.6 µM 1.33885355126291 0.129290472858169 no 483 0.0903091766824468 529 4017482 SGTC_414 piperonyl butoxide 100 µM 1.33589752986966 0.129814344588733 no 484 0.0907913842237145 508 5794 A potent inhibitor of cytochrome P450. SGTC_3284 9108171 64.8615 µM 1.33565920552066 0.12985664481893 no 485 0.0908303444817431 484 8687505 SGTC_1361 1608-0041 5.61 µM 1.33507936402816 0.129959600838966 no 486 0.0909251863245605 536 X1361 SGTC_2307 7538926 6.34 µM 1.33431811092622 0.130094853876539 no 487 0.0910498122955539 546 96582 SGTC_641 4092-0595 30 µM 1.33179568801602 0.130543712779513 no 488 0.0914636676449056 541 786260 SGTC_1887 st057648 70.8 µM 1.32581134032685 0.131612893251484 no 489 0.0924510978746438 527 688672 SGTC_707 0865-0008 204 µM 1.32174825953494 0.132342250227127 no 490 0.0931259963586954 539 723043 SGTC_1694 st024011 44.9 µM 1.32174312191083 0.132343174233632 no 491 0.0931268520431225 577 2787533 SGTC_1725 st036284 20.55 µM 1.32057089693916 0.132554116247006 no 492 0.0933222410531901 586 707914 SGTC_2476 5806916 10.51 µM 1.32038520013184 0.132587553650553 no 493 0.0933532211699861 504 2870194 SGTC_1214 0358-0031 63.7 µM 1.32028892610134 0.132604891473192 no 494 0.0933692857218418 540 4301366 SGTC_2512 diallyl trisulfide 49.23 µM 1.31857934725163 0.132913026682831 no 495 0.0936548909879229 479 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_867 0518-0118 155 µM 1.31718461587706 0.133164778537107 no 496 0.0938883746676412 534 6848158 SGTC_2217 6934799 96.0675 µM 1.31563162444624 0.13344548255637 no 497 0.0941488569060942 524 675606 SGTC_2051 5263410 176 µM 1.31111530855776 0.134264120753454 no 498 0.0949094047518064 555 227584 SGTC_2420 aureobasidin a 50 nM 1.30748956892143 0.13492382203618 no 499 0.0955232476345343 586 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3014 9081533 49.47 µM 1.30496848590532 0.135383840103929 no 500 0.0959517894737048 559 21367265 SGTC_1626 st003712 1.76 µM 1.30268312558444 0.135801774103827 no 501 0.0963414826623815 517 24207035 SGTC_224 benfluorex 43.875 µM 1.30168147328405 0.135985228919588 no 502 0.0965126477201784 429 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1670 st016595 4.04 µM 1.29852474680038 0.136564499880116 no 503 0.0970535391377332 550 597879 SGTC_2882 9058044 58.44 µM 1.29841465611636 0.136584732333714 no 504 0.0970724427704473 521 18076804 SGTC_1573 oleylamine 1.06 µM 1.29589587206324 0.137048194180955 no 505 0.0975056808018744 554 5356789 An amine of the fatty acid oleic acid. SGTC_2966 9084041 48.03 µM 1.29502957015772 0.137207843701505 no 506 0.0976550144610332 535 17741380 SGTC_753 1322-0200 289 µM 1.29039152234578 0.138064743106454 no 507 0.0984573770539914 545 5403907 SGTC_1189 1431-2119 7.28 µM 1.28573093899015 0.138929475046414 no 508 0.0992684898274206 582 3107275 SGTC_1594 piperine 70.1 µM 1.28268766596487 0.139496114736759 no 509 0.099800761392251 567 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_142 0335-0849 62.6745 µM 1.28057193580384 0.139890976392501 no 510 0.100172031323333 683 3889043 YPR107C YTH1 SGTC_644 1498-1197 63.3 µM 1.27681344306455 0.140594300943076 no 511 0.100834059178526 605 6741615 SGTC_124 0136-0217 7.121 µM 1.27110135218683 0.141667789858521 no 512 0.101846297180581 654 3976905 SGTC_587 k089-0003 57 µM 1.26634494428408 0.142565900659985 no 513 0.102694806313404 405 9659696 SGTC_3115 9123671 49.47 µM 1.26506641578317 0.142807969148486 no 514 0.102923760324965 569 3286988 SGTC_3220 9131269 49.47 µM 1.26419141775642 0.142973795775214 no 515 0.103080665237395 544 17722206 SGTC_1632 st005650 90 µM 1.26272364223316 0.143252255656775 no 516 0.103344257207423 561 2759605 SGTC_1251 0490-5699 265 µM 1.26251925040661 0.14329106100502 no 517 0.103381001903083 641 3883818 SGTC_1481 3346-2004 36 µM 1.26178181897629 0.143431126997341 no 518 0.103513653033477 571 2770522 SGTC_356 1634-0012 32.5 µM 1.26132300667481 0.143518319359809 no 519 0.103596247726061 611 735457 SGTC_13 0199-0087 65 µM 1.25885238175195 0.143988450165614 no 520 0.104041828045216 599 4589825 SGTC_1006 4099-6547 255 µM 1.25862179460875 0.144032381114969 no 521 0.104083485518875 581 3146833 SGTC_2168 5727979 200 µM 1.25716496094886 0.144310142766716 no 522 0.104346954140236 520 695210 SGTC_2531 methyl deoxycholate 70.07 µM 1.25559471645924 0.14460993151482 no 523 0.10463147398059 555 16667744 Haematoxylin. SGTC_52 0329-0193 875 nM 1.25520035001439 0.144685289238881 no 524 0.10470301925998 572 3739292 SGTC_2534 helenine 20.12 µM 1.25453079246695 0.144813292568943 no 525 0.104824570365253 522 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1760 st045453 10.4495 µM 1.25362906753784 0.144985801201645 no 526 0.104988430424731 622 3323419 YIL048W NEO1 SGTC_1259 0671-0132 43 µM 1.25131404216918 0.145429321037968 no 527 0.105409962140988 568 X1259 SGTC_488 nitrendipine 139 µM 1.24928931531176 0.14581797190798 no 528 0.105779637238225 609 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2651 TUB2.036 5 µM 1.2483354492949 0.146001310319708 no 529 0.105954118704048 770 15992207 YFL037W TUB2 SGTC_376 3970-0862 59.1 µM 1.24514441307622 0.146615770749375 no 530 0.10653933554712 600 3135186 SGTC_3255 9139072 49.47 µM 1.24393556292384 0.146848997447596 no 531 0.106761639701472 599 17646060 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.24223290022328 0.147177918633607 no 532 0.107075322076169 619 2333 A French combination drug. SGTC_14 0354-0009 295 µM 1.24036725415665 0.147538891680023 no 533 0.107419793553601 605 1713507 SGTC_1127 asiatic acid 681.4 nM 1.24028245235366 0.147555313569698 no 534 0.107435470251513 579 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2260 7964312 200 µM 1.24025875010628 0.147559903734581 no 535 0.107439852209942 534 231951 SGTC_2472 5377652 49.4 µM 1.23631203470954 0.148325556745746 no 536 0.108171299692181 624 1610903 SGTC_1070 indatraline 8.81 µM 1.2355543194552 0.148472855157637 no 537 0.108312136767977 599 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_463 ikarugamyin 104 µM 1.23174372945824 0.14921510923969 no 538 0.109022414549965 517 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_853 0419-0306 21 µM 1.23142024231663 0.149278234297351 no 539 0.109082864982995 563 762713 SGTC_1027 k015-0025 8.67 µM 1.22966915913548 0.149620248928889 no 540 0.109410510157686 601 3598955 SGTC_2499 avocadenofuran 51.48 µM 1.22879310098729 0.149791553212336 no 541 0.109574694422909 597 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_992 3909-8734 162 µM 1.22859333076535 0.149830634563384 no 542 0.109612158621548 580 4288319 SGTC_1932 st074806 40.9 µM 1.22795418055776 0.14995571817125 no 543 0.10973208436653 652 17251235 SGTC_469 w7 172 µM 1.22708834099486 0.150125276592615 no 544 0.109894694723155 542 45115570 A P450 inhibitor. SGTC_2666 tannic acid 100 µM 1.22662909390243 0.150215263365484 no 545 0.109981014497595 642 16134267 A thiamine antagonist. SGTC_306 1672-3436 11.6 µM 1.22138066628642 0.151246214797479 no 546 0.110970961960903 625 6797378 SGTC_801 0866-0028 10.1 µM 1.22013508270953 0.151491574850387 no 547 0.11120683555421 644 6849771 SGTC_1250 0485-0349 40.2 µM 1.2164596255772 0.152217122970111 no 548 0.111904941105869 579 6842794 YDL195W SEC31 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.21496712646213 0.152512405096442 no 549 0.112189314816937 599 229346 A bile salt which induces apoptosis. SGTC_295 k015-0027 31 µM 1.2140730879237 0.152689467252566 no 550 0.112359907853918 606 3887424 SGTC_1213 1315-0166 115 µM 1.21258560391622 0.152984361889202 no 551 0.11264414782375 526 768401 SGTC_3030 9087619 49.47 µM 1.21237683594479 0.153025780465804 no 552 0.112684081882558 569 25236973 SGTC_2906 7926292 26.41 µM 1.21230761256544 0.153039515697254 no 553 0.112697325467633 602 2966319 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.2108556916859 0.153327792669258 no 554 0.112975358286789 625 4213774 SGTC_2748 diazoxide 86.69 µM 1.20807027811485 0.153881839349981 no 555 0.113510115534486 558 3019 A potassium channel activatior. SGTC_3305 9127027 53.8275 µM 1.20798819020728 0.153898187531713 no 556 0.113525902503727 615 41905295 SGTC_2180 6301957 200 µM 1.20748885753756 0.153997656673524 no 557 0.113621966812183 602 845462 SGTC_750 4073-0104 132 µM 1.20530875303705 0.154432440743708 no 558 0.114042065900884 499 22330957 SGTC_1025 k007-0731 70 µM 1.20516437009037 0.154461264045307 no 559 0.114069927044167 594 6256118 SGTC_281 1672-3440 14.9 µM 1.20352850039946 0.154788082623568 no 560 0.114385934627736 666 6833000 SGTC_1852 st056254 31.4 µM 1.2031785947034 0.154858047018118 no 561 0.114453608168119 604 442583 SGTC_1002 4049-0206 172 µM 1.2030943573043 0.154874893586135 no 562 0.114469904365147 671 4662749 SGTC_1970 st070122 35.8 µM 1.20159346989786 0.155175257751698 no 563 0.114760536370877 617 102928 SGTC_2278 7948257 134.34 µM 1.19917862626587 0.155659333429274 no 564 0.115229248159823 620 1247028 SGTC_3331 9141060 1.957 µM 1.19064820511737 0.157377292888145 no 565 0.1168958595567 582 4906567 YPR165W RHO1 SGTC_1952 st077036 64.1 µM 1.18829323119991 0.157853753015789 no 566 0.117358951769966 634 2937007 SGTC_55 0767-0285 6.563 µM 1.1877850214341 0.15795669854817 no 567 0.117459058535878 668 3116166 SGTC_3052 9092717 49.47 µM 1.18743031227075 0.158028576338748 no 568 0.11752896468945 591 25237534 SGTC_3083 9117465 49.47 µM 1.18724735201654 0.158065659552807 no 569 0.117565034045983 612 16420915 SGTC_2720 fluspirilene 36.88 µM 1.18627844383858 0.158262137474632 no 570 0.117756178269994 570 3396 An atypical antipsychotic. SGTC_2935 9038016 29.96 µM 1.18612252784327 0.158293769520826 no 571 0.117786957590165 666 6463195 SGTC_1961 st076550 68.7 µM 1.18286167569557 0.158956277779282 no 572 0.11843198622505 586 1579337 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.18277211902607 0.158974498632855 no 573 0.118449736573812 627 390807 SGTC_1118 chelidonine 707.474 nM 1.18211267401644 0.159108708904057 no 574 0.118580498073425 690 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2860 9025725 38.96 µM 1.18179001936477 0.159174402625106 no 575 0.118644514488557 573 40546248 SGTC_1526 st051518 75 µM 1.18083162636045 0.159369639853537 no 576 0.118834808780693 591 673993 SGTC_2036 5160441 105 µM 1.17697006808631 0.160157877880685 no 577 0.119603726667144 725 134534 YIL048W NEO1 SGTC_3005 9076496 71.4286 µM 1.17666570541425 0.160220113884791 no 578 0.119664480567863 604 21368410 SGTC_982 1491-0518 27.5 µM 1.17557078529543 0.160444133589593 no 579 0.119883217790156 589 3091256 SGTC_879 0831-1030 162 µM 1.17341803563206 0.160885180753435 no 580 0.120314104067305 694 1549252 SGTC_542 3381-0244 89.3 µM 1.17182666879111 0.16121172224063 no 581 0.120633326611492 714 1112843 SGTC_2675 theaflavin digallate 100 µM 1.16927568971875 0.161736073388655 no 582 0.121146287217058 665 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_5 0352-0601 109.883 µM 1.16776062893534 0.162048018087127 no 583 0.121451666634655 590 762456 SGTC_1013 4112-3890 241 µM 1.1642706043111 0.162768089601998 no 584 0.122157182677711 660 705171 SGTC_2032 5185112 25.99 µM 1.16324261205333 0.162980583952926 no 585 0.122365541078056 603 5718189 SGTC_1401 3807-4679 7.6 µM 1.16088071907221 0.163469489291188 no 586 0.122845205423083 608 3291456 SGTC_1129 3453-1384 223 µM 1.153197683226 0.165066437945799 no 587 0.124414627119015 697 1084452 SGTC_2993 9054257 71.4286 µM 1.15300888745513 0.165105806597029 no 588 0.124453368322662 656 6470217 YGL055W OLE1 SGTC_584 0986-0246 15.4 µM 1.15240206321246 0.16523238582665 no 589 0.124577946782106 717 53315 YDR232W HEM1 SGTC_2021 4019055 173 µM 1.15230474532157 0.165252691490122 no 590 0.124597933843393 797 44827708 YER133W GLC7 SGTC_736 0958-0254 92.6 µM 1.15135114623325 0.165451748175265 no 591 0.124793901770985 707 6812352 SGTC_347 4534-1311 26.2 µM 1.14723295361056 0.166313170634397 no 592 0.125642677716768 669 2862016 SGTC_428 3448-4153 16.5 µM 1.14535924558576 0.166706060250878 no 593 0.126030186605118 583 3834874 SGTC_1922 5578187 25 µM 1.14463166645773 0.166858784430181 no 594 0.126180884469872 630 1350412 SGTC_1394 3474-0001 65.7 µM 1.14101641904841 0.167618989231027 no 595 0.126931545212618 586 5017666 YIL048W NEO1 SGTC_3113 9123498 49.47 µM 1.13966451731258 0.167903835776423 no 596 0.127213047583919 672 8897275 SGTC_2799 7812892 81.82 µM 1.13584188656533 0.16871095158482 no 597 0.128011371650663 712 20205235 SGTC_1640 st009078 66.4 µM 1.13377182744848 0.169149065883902 no 598 0.128445135674148 600 690618 SGTC_934 2950-0684 338 µM 1.13276486806322 0.169362446040478 no 599 0.128656504260508 712 1121253 SGTC_1904 st060225 78 µM 1.13268045241003 0.169380342020784 no 600 0.12867423471942 671 66595 SGTC_2155 5570423 76 µM 1.13049945808443 0.169843129960845 no 601 0.129132913331579 655 797402 SGTC_1029 k015-0030 64.7 µM 1.12990700237402 0.169968983789846 no 602 0.129257706525667 662 2208316 SGTC_2158 5657123 3.6195 µM 1.12988038052585 0.169974640403115 no 603 0.129263316038228 680 2858827 SGTC_3145 9085516 49.47 µM 1.12446908494747 0.171126937961101 no 604 0.130407039232267 650 25236195 SGTC_2680 butyl paraben 22.24 µM 1.12437271217842 0.171147505044375 no 605 0.130427471675075 655 7184 An antifungal and steroid mimetic. SGTC_1664 st014217 9.02 µM 1.12215988185811 0.171620183891062 no 606 0.130897233399216 739 3982782 SGTC_2712 st079126 47.7 µM 1.12158764739304 0.171742553503281 no 607 0.131018903088715 636 3152970 SGTC_379 3970-0972 5.9 µM 1.11858320871716 0.172385952543457 no 608 0.131658995086324 681 2898042 YBL034C STU1 SGTC_219 mitoxanthrone 164.414 µM 1.11775754641564 0.172563036698392 no 609 0.131835278821966 664 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_432 NS 1619 61.3 µM 1.11453373599322 0.173255574510472 no 610 0.132525139959203 623 4552 A K+/calcium channel activator. SGTC_2156 5649887 115 µM 1.11284842566754 0.173618315705276 no 611 0.13288676670063 779 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3221 9128209 49.47 µM 1.1098364504737 0.174267806898085 no 612 0.133534754521638 663 16460723 SGTC_2381 9035592 200 µM 1.10799683384184 0.174665253479875 no 613 0.133931591640361 628 4749657 SGTC_640 3381-0960 37.1 µM 1.10483268590745 0.175350208249803 no 614 0.13461604727828 734 1745025 SGTC_2214 7179297 48.276 µM 1.10481267025003 0.175354546526401 no 615 0.134620384611658 704 769744 SGTC_1646 st011709 75.6 µM 1.10221044561017 0.175919142952626 no 616 0.135185095917735 657 5757843 SGTC_335 4077-0256 27.6 µM 1.10047920411735 0.176295401912504 no 617 0.135561692800091 786 3121989 SGTC_442 cape 100 µM 1.10024931142055 0.176345403859979 no 618 0.135611755358011 674 5281787 SGTC_1202 1988-0068 29.6 µM 1.09373239149037 0.177766573211551 no 619 0.137036181782548 736 2850480 SGTC_1397 3532-0190 20.1 µM 1.0921903098544 0.178103915015017 no 620 0.137374730405141 630 5322280 SGTC_3273 9137859 49.47 µM 1.09067514106575 0.178435762220607 no 621 0.137707926407125 712 2377234 SGTC_1622 st003707 19.4 µM 1.0905709975462 0.178458585683984 no 622 0.137730848519962 753 10140899 SGTC_2608 thymoquinone 42.66 µM 1.0901740143389 0.178545602985668 no 623 0.137818248875272 663 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1108 betulinic acid 729.144 nM 1.08948238046806 0.178697270485748 no 624 0.137970610293173 715 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1317 1273-0028 910 nM 1.08743064348403 0.179147670314092 no 625 0.138423267324103 722 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1813 st051246 8.6015 µM 1.0845295923787 0.179785730111709 no 626 0.139065026759236 679 5291959 SGTC_473 2-arachidonoylglycerol 10 µM 1.08095076835112 0.180574824102001 no 627 0.139859506869346 704 5282280 An endocannabinoid. SGTC_871 0574-0004 149 µM 1.07970684605367 0.180849604135738 no 628 0.140136372173471 763 9551173 SGTC_1471 k673-0312 37 µM 1.07760035720467 0.18131552078812 no 629 0.140606071372928 716 24099884 SGTC_1335 1486-0900 202 µM 1.07731882167136 0.181377848170037 no 630 0.140668928262729 749 X1335 SGTC_2521 angolensin 13.4 µM 1.07727863464796 0.181386746016451 no 631 0.140677902153489 681 821428 A flavenoid. SGTC_579 4491-1009 110 µM 1.07696622223963 0.181455926859819 no 632 0.140747678092781 925 1271041 SGTC_175 3793-3120 23.7 µM 1.07528423745344 0.18182867064923 no 633 0.141123745546575 672 5322297 SGTC_1076 itraconazole 331 nM 1.0749382630967 0.181905401198144 no 634 0.141201184817343 749 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2421 5690543 90.72 µM 1.07324891642751 0.182280357025205 no 635 0.141579724198266 731 3397993 SGTC_672 1441-0018 53.7 µM 1.07275203145684 0.182390734070027 no 636 0.141691194144246 695 251141 SGTC_1874 staurosporine 7.6 µM 1.07250509297069 0.182445604026611 no 637 0.141746613821324 761 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2007 4011539 71.82 µM 1.07171706903282 0.18262077261255 no 638 0.141923565882144 718 45595301 SGTC_3094 9117742 49.47 µM 1.06439248955712 0.184253962857653 no 639 0.143575467333887 779 17149698 SGTC_196 k015-0023 18.111 µM 1.06423029308546 0.184290231004353 no 640 0.143612193537181 764 5211998 SGTC_2299 7976368 114.88 µM 1.06324489825139 0.184510666922315 no 641 0.143835453097792 732 2979718 SGTC_2404 5161160 200 µM 1.05881686137054 0.185503255571737 no 642 0.144841596541231 780 2831543 SGTC_3196 9111891 49.47 µM 1.05880377817087 0.185506193203248 no 643 0.144844576325065 711 18891510 SGTC_2708 st078559 56 µM 1.05823603721779 0.185633698523376 no 644 0.144973922782018 641 17250902 SGTC_2946 9065502 71.43 µM 1.05738451200402 0.185825039054765 no 645 0.145168068556649 582 16489101 SGTC_1570 verbenone 133 µM 1.05706202933192 0.185897533900436 no 646 0.145241639514257 778 29025 A natural terpanoid with antifungal properties. SGTC_2785 7756463 72.73 µM 1.05596400035504 0.186144504835794 no 647 0.145492331142152 725 2201551 SGTC_2399 5884133 200 µM 1.0550986663009 0.186339280763769 no 648 0.145690100975104 726 722445 SGTC_1041 0206-0046 107 µM 1.05439552384414 0.18649764233053 no 649 0.145850935375119 745 50494 SGTC_2977 9011197 71.43 µM 1.05408223674099 0.186568227607239 no 650 0.145922634008808 668 2704722 SGTC_2572 astragaloside iv 100 µM 1.05390978911959 0.1866070880461 no 651 0.145962110337378 728 45006101 An anti-inflammatory agent. SGTC_1458 k015-0034 6.33 µM 1.05246996842623 0.186931741939487 no 652 0.146291990974116 707 3598957 SGTC_1628 st004252 77.7 µM 1.04887134324827 0.187744694850816 no 653 0.147118668152201 753 692968 SGTC_1399 3562-5772 25 µM 1.04832923510775 0.187867349606044 no 654 0.147243472299579 665 23847490 SGTC_2339 9000433 200 µM 1.04721394080648 0.188119846251951 no 655 0.147500458507557 662 2988954 SGTC_583 1488-1091 88.9 µM 1.04412647664026 0.188819923298334 no 656 0.148213438804479 893 4303273 SGTC_3020 9089140 49.47 µM 1.04391876419026 0.188867079298004 no 657 0.148261487958175 732 17217859 SGTC_2529 gangaleoidin 93.61 µM 1.04279829385189 0.189121579643705 no 658 0.148520860855047 776 4565183 SGTC_2319 6033012 152.6 µM 1.04130706977408 0.18946061931301 no 659 0.148866528299378 701 847246 SGTC_1146 3579-1023 7 µM 1.03959659610096 0.189849967070401 no 660 0.149263679506085 847 X1146 SGTC_967 1306-0166 352 µM 1.0375883496888 0.190307722940543 no 661 0.149730872065811 776 4437607 SGTC_1867 st057372 64 µM 1.03709558796606 0.190420145611632 no 662 0.149845655597753 745 688837 SGTC_3090 9117696 49.47 µM 1.03669001084189 0.190512707870856 no 663 0.149940174437712 761 7923821 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.03642819207745 0.190572475754484 no 664 0.150001211826493 734 6708514 SGTC_1686 st019653 115.5 µM 1.03552484125797 0.190778780680867 no 665 0.150211935733724 766 97252 SGTC_1351 1496-0003 46.5 µM 1.03373149955502 0.191188745315359 no 666 0.150630851465531 802 3891978 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.03193240967327 0.191600566264412 no 667 0.15105189100503 723 688803 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.03191348548227 0.191604900995058 no 668 0.151056323976113 789 688667 SGTC_1912 st060209 90.8 µM 1.03176984654901 0.191637804549292 no 669 0.151089974061644 721 688787 SGTC_2195 6536160 144.242 µM 1.03158026122481 0.191681238400069 no 670 0.151134395577405 692 3834386 SGTC_537 1334-0398 209 µM 1.03021896861592 0.191993286509033 no 671 0.151453613636048 800 5846986 SGTC_375 3970-0961 9.27 µM 1.02894346231855 0.192285951837486 no 672 0.151753121659293 784 2898222 SGTC_2504 purpurogallin 52.29 µM 1.02799212392011 0.192504414287502 no 673 0.151976766285479 738 5281571 An antioxidant. SGTC_2423 st077119 87.2 µM 1.02751551127197 0.192613919190401 no 674 0.152088892664036 759 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2098 5376439 882.5 nM 1.02712409060537 0.192703879138643 no 675 0.152181018123302 817 2844116 SGTC_3213 9129884 49.47 µM 1.02711289053289 0.192706453621529 no 676 0.152183654737307 683 17190742 SGTC_647 0140-0236 81 µM 1.02477747429308 0.193243738544444 no 677 0.152734098687863 865 990837 SGTC_1105 epirubicin 18.1 µM 1.02331182552262 0.19358139157547 no 678 0.153080217124464 757 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2775 cyproheptadine 69.59 µM 1.02058687284009 0.194210115974064 no 679 0.153725105723442 791 2913 A selective serotonin reuptake inhibitor. SGTC_2649 anisomycin 9.56 µM 1.01980152035361 0.1943915498323 no 680 0.153911301002957 772 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2053 5265679 138 µM 1.01938765901193 0.194487202492861 no 681 0.154009481333729 780 764595 SGTC_1019 4262-0212 3.4 µM 1.01930327933878 0.194506708047669 no 682 0.154029503809021 845 4677213 SGTC_1986 st071812 45 µM 1.016403688161 0.195177712814165 no 683 0.154718595027683 746 11838594 SGTC_969 1313-0238 134 µM 1.01414177499825 0.195702125714701 no 684 0.155257553423368 816 5212874 SGTC_2874 9043904 71.43 µM 1.01326287512009 0.195906124646851 no 685 0.155467307598978 696 4463428 SGTC_2786 7743617 45.45 µM 1.01248303492354 0.196087239109138 no 686 0.155653577122942 695 583674 SGTC_1337 1486-1011 40.3 µM 1.01175834130944 0.196255637023926 no 687 0.155826806446771 794 X1337 SGTC_787 4152-0075 138 µM 1.00997307238219 0.196670855977856 no 688 0.156254095649377 755 9566539 SGTC_118 0083-0097 135.343 µM 1.00916863576426 0.196858126122932 no 689 0.156446882849684 987 5207356 SGTC_341 1486-1430 230 µM 1.00526105041483 0.197769333902724 no 690 0.157385582447092 765 2054753 YPL210C SRP72 SGTC_1689 st020265 53.493 µM 1.00496178589443 0.197839224148863 no 691 0.157457625568723 815 5758320 YPR016C TIF6 SGTC_1547 harmine 94.2 µM 1.00466550572642 0.197908432126657 no 692 0.157528971602608 865 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3103 9120822 49.47 µM 1.0038438650118 0.198100435385244 no 693 0.157726938720008 820 17141819 SGTC_1633 st005664 67.9 µM 1.00371172892035 0.198131323805043 no 694 0.157758790998615 797 2063822 SGTC_3059 1327-0034 3 µM 1.00321870057598 0.198246600845975 no 695 0.157877676031309 783 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2980 9014342 25.29 µM 1.0018947633416 0.198556356466504 no 696 0.158197211025588 742 2996599 SGTC_2864 9034755 47.6 µM 0.999709691433033 0.199068225951358 no 697 0.158725510302273 839 4930451 SGTC_1173 0443-0020 122 µM 0.999270177382306 0.19917128137465 no 698 0.158831914080796 786 5331295 SGTC_2600 tangeritin 87.95 µM 0.998719753864755 0.199300387701493 no 699 0.158965234314969 734 68077 A bioactive flavone. SGTC_2706 st078239 82.5 µM 0.998695032706221 0.19930618743323 no 700 0.158971223843717 809 15434492 SGTC_24 0417-1663 219 µM 0.997701972601149 0.199539249309884 no 701 0.159211948200779 775 4329390 SGTC_724 3910-0327 137 µM 0.996309918957334 0.199866227205856 no 702 0.159549792932297 808 2885483 SGTC_783 0848-0141 92.7 µM 0.996082495164938 0.199919677128627 no 703 0.159605032153448 765 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1275 0867-0008 21.1 µM 0.994706958959493 0.200243143564459 no 704 0.159939404451297 809 3422836 SGTC_3272 9137413 49.47 µM 0.993081214444928 0.200625853373832 no 705 0.160335188958858 771 17614870 SGTC_2358 9037157 4 µM 0.992912784104198 0.200665527955366 no 706 0.160376229574537 802 2388925 SGTC_2779 methotrexate 400 µM 0.992826136687927 0.200685940008106 no 707 0.16039734520997 849 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2425 5628681 7.85 µM 0.992032230308436 0.200873023331278 no 708 0.160590901653662 911 5714958 SGTC_1840 st055363 71 µM 0.987457521991951 0.201953086631803 no 709 0.161709198583656 756 676033 SGTC_2276 7947513 42.08 µM 0.984870665860111 0.202565364661892 no 710 0.162343801971529 738 2105100 SGTC_1039 k821-0043 94 µM 0.982668637433636 0.203087431823741 no 711 0.162885275577668 842 15992768 SGTC_2192 5915882 198.485 µM 0.979589701303827 0.203818745739419 no 712 0.163644345298845 792 2876149 SGTC_2197 6588183 93.1375 µM 0.977397913014109 0.204340297984011 no 713 0.164186097906176 799 884136 SGTC_399 oxolinic acid 75 µM 0.975400341644309 0.204816326236247 no 714 0.164680857134932 807 4628 A DNA gyrase inhibitor. SGTC_2185 6113692 200 µM 0.975077479164599 0.20489332735864 no 715 0.164760914422544 769 874150 SGTC_3123 9126162 49.47 µM 0.97455985499475 0.205016814104907 no 716 0.16488931760642 806 25239884 SGTC_1914 st062367 72.6 µM 0.973187871178983 0.205344334681262 no 717 0.16522996888967 786 978205 SGTC_2396 5342950 42.78 µM 0.97269117265333 0.205462983351249 no 718 0.165353406896792 832 1886677 SGTC_99 0109-0120 622.8 µM 0.968623470267588 0.206436185074142 no 719 0.166366544369686 798 759414 SGTC_2463 5473429 200 µM 0.967715729741608 0.206653735035923 no 720 0.166593180062515 806 5399405 SGTC_722 3534-0461 190 µM 0.967601242321684 0.206681182838635 no 721 0.16662177829576 841 658262 SGTC_433 pimozide 108 µM 0.966289501658517 0.206995820323373 no 722 0.166949668913617 703 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3355 9151058 44.0485 µM 0.964149164263219 0.207509815234369 no 723 0.167485573444044 822 17015728 SGTC_365 0121-0052 13.6 µM 0.960742486647987 0.208329471536382 no 724 0.168340831494363 890 3101739 SGTC_667 1498-1044 59 µM 0.960422408186707 0.208406581350822 no 725 0.168421332389539 873 6739982 SGTC_456 gingerol 170 µM 0.959556008272318 0.208615389407889 no 726 0.168639359283344 865 442793 A herb. SGTC_1334 1486-0610 236 µM 0.959416360461438 0.208649056983057 no 727 0.168674518198373 839 3742339 SGTC_2223 6903751 107.57 µM 0.958556047207653 0.208856539826397 no 728 0.168891221851471 792 5598863 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.957467780359745 0.209119172594236 no 729 0.169165600672827 919 5024745 SGTC_1366 1683-0113 21.9 µM 0.957436178044232 0.209126802123961 no 730 0.169173572667341 819 708623 SGTC_932 2857-0803 154 µM 0.957307222562061 0.20915793665816 no 731 0.169206105454804 904 674898 SGTC_2880 9042983 58.44 µM 0.957246022813488 0.209172713453742 no 732 0.16922154628453 827 6464714 SGTC_1982 st072467 71.9 µM 0.956808984915263 0.209278254949785 no 733 0.169331838192474 892 3163533 SGTC_2072 5231554 129 µM 0.956754362016486 0.209291448188576 no 734 0.169345626198253 924 789545 SGTC_1530 rhein 70.4 µM 0.956355632768653 0.209387769333296 no 735 0.169446295946948 902 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_95 0471-0001 561.058 µM 0.95613059584619 0.209442143084251 no 736 0.169503129422382 807 4015405 SGTC_1273 0849-0096 14.1 µM 0.955372182672412 0.209625453154723 no 737 0.169694758080494 842 5286025 SGTC_207 4185-0010 4.486 µM 0.955227775633049 0.209660367332491 no 738 0.169731261225301 942 3761753 SGTC_56 0957-0365 83.25 µM 0.953830012009642 0.209998489944585 no 739 0.170084847523833 839 6752360 SGTC_1249 0481-0015 10.2 µM 0.95371216475824 0.210027012136378 no 740 0.170114680403461 801 4227577 SGTC_603 3794-0023 45.9 µM 0.951618602564401 0.210534089555004 no 741 0.170645221846855 844 3802260 SGTC_2178 5812956 200 µM 0.947798412073004 0.21146121950887 no 742 0.171616044540635 853 5403383 SGTC_2794 7785382 27.27 µM 0.947667822499338 0.21149295476756 no 743 0.171649293445012 925 2205081 SGTC_671 0560-0003 407 µM 0.942820232002375 0.212672965102999 no 744 0.172886430648684 837 3238678 SGTC_2050 5263056 171 µM 0.942623603544463 0.212720909793994 no 745 0.172936731153192 917 763468 YGL055W OLE1 SGTC_1145 3546-0597 10.2 µM 0.936773223769047 0.214150315753266 no 746 0.17443761073434 880 875334 SGTC_2933 9026794 32.47 µM 0.935984443585668 0.21434346273525 no 747 0.174640598657207 874 17586027 SGTC_3008 9078912 71.4286 µM 0.93554838356154 0.214450283331185 no 748 0.174752880479281 839 16648731 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.935270768031017 0.214518306276813 no 749 0.174824388033813 852 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_541 4513-1321 94 µM 0.934985431671519 0.214588234094596 no 750 0.174897903652143 811 747515 SGTC_731 3966-0296 387 µM 0.932899064565743 0.215099945765684 no 751 0.175436042704181 867 660956 SGTC_2383 9036125 200 µM 0.931606422189544 0.215417340092868 no 752 0.175769981464857 840 79580 SGTC_1331 1472-0049 76.2 µM 0.930174391449916 0.215769276739656 no 753 0.176140399352415 819 24051409 SGTC_799 1310-0557 151 µM 0.929155676529815 0.216019839411556 no 754 0.176404206979679 874 5354492 SGTC_77 0828-0286 12.516 µM 0.928795147380357 0.216108555367636 no 755 0.176497629891143 881 745345 SGTC_1778 st046819 58.9 µM 0.926412365569328 0.216695420466713 no 756 0.177115860153919 939 671715 SGTC_2628 lathosterol 100 µM 0.925009728739559 0.217041312186486 no 757 0.177480423446155 881 6710616 SGTC_2247 cerulenin 830 nM 0.924863582797727 0.217077370274009 no 758 0.177518435878839 883 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2956 9076196 2.52 µM 0.9206600107244 0.218115983871148 no 759 0.178613980212533 904 16423868 SGTC_2215 7188065 200 µM 0.919691442625702 0.218355701897624 no 760 0.178867012872398 873 940217 SGTC_2982 9019404 25.97 µM 0.918348348478519 0.218688365129252 no 761 0.179218261378349 793 22333232 SGTC_2122 5258151 111.688 µM 0.918256667836071 0.218711083608791 no 762 0.17924225367915 861 2173356 SGTC_1478 0453-0656 35.7 µM 0.917114475164453 0.218994233011542 no 763 0.179541328310174 909 5258496 SGTC_1662 st014054 52 µM 0.914905644567612 0.219542399484529 no 764 0.180120583273584 866 2838777 SGTC_844 0330-0132 15.3 µM 0.913074975695053 0.219997314071558 no 765 0.180601555238537 956 2828079 SGTC_3040 9091894 49.47 µM 0.912137821659867 0.220230402596365 no 766 0.180848085290776 820 25236966 SGTC_2962 9082311 13.18 µM 0.911318845642856 0.22043421383938 no 767 0.181063699767943 844 16459453 SGTC_501 nsc-95397 161 µM 0.910436238482761 0.220653981375796 no 768 0.181296246853316 868 262093 SGTC_277 nystatin 15.5 µM 0.907865763171937 0.221294739489861 no 769 0.181974574044585 953 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2102 5377816 72.7585 µM 0.906919762536724 0.221530822486178 no 770 0.182224614790363 943 1379702 SGTC_393 acivicin 6.25 µM 0.906485788078883 0.221639172880419 no 771 0.182339391912957 836 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1667 st014849 34.6 µM 0.906034838917823 0.221751793425139 no 772 0.182458706333201 916 5348460 SGTC_1439 4092-1168 46 µM 0.903073297042401 0.222492224066907 no 773 0.183243497525217 919 2886240 SGTC_1821 st053465 65.6 µM 0.901366882303572 0.22291949318654 no 774 0.183696641864107 861 675086 SGTC_3021 9087658 49.47 µM 0.900964531184216 0.223020305922995 no 775 0.183803589228156 912 25237042 SGTC_165 k038-0023 64.381 µM 0.898478970840027 0.223643661046187 no 776 0.184465125759385 925 46368543 SGTC_1437 4092-1038 11.6 µM 0.898294915979924 0.223689859636618 no 777 0.184514171129105 955 3977136 SGTC_2360 9040895 200 µM 0.897736310830308 0.223830105238977 no 778 0.184663073120788 851 4914414 SGTC_2718 lomofungin 53.02 µM 0.89724330405525 0.223953922962921 no 779 0.184794551234755 885 5351222 A RNA synthesis inhibitor. SGTC_2009 4012297 12.05 µM 0.895413509221747 0.224413812612882 no 780 0.185283040872961 838 45595307 SGTC_1246 0422-0085 105 µM 0.89358375297592 0.224874228059734 no 781 0.185772321192762 947 264295 SGTC_691 1548-0686 185 µM 0.89354297072988 0.224884496056995 no 782 0.185783235566003 906 46495133 SGTC_2811 7967822 32.47 µM 0.892949021923937 0.22503406832561 no 783 0.185942236549739 905 2232244 SGTC_1744 st037937 38.9 µM 0.892026422670849 0.225266515364075 no 784 0.186189385020911 902 1016152 SGTC_600 1495-0418 41.6 µM 0.891036787261253 0.225516003121893 no 785 0.186454717521652 893 5377768 SGTC_3175 9106517 49.47 µM 0.889146461489989 0.225992989929291 no 786 0.186962185871897 895 41468073 SGTC_48 0382-0018 55 µM 0.888511091579881 0.226153441098648 no 787 0.187132946122788 911 762596 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.885485379344434 0.226918412556319 no 788 0.187947450859155 923 115019 SGTC_749 1000-0129 128 µM 0.881998324969778 0.227801829557348 no 789 0.188888856541777 994 708470 SGTC_3341 9147222 25.867 µM 0.881639827197014 0.227892761657291 no 790 0.188985805193193 876 1939759 SGTC_1984 st072354 53.1 µM 0.879851148807556 0.228346760655496 no 791 0.189469975842507 927 5762938 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.879745551837587 0.228373578960734 no 792 0.189498583332616 991 688664 SGTC_3166 9102297 49.47 µM 0.878343881617477 0.228729726690999 no 793 0.189878564411883 927 25237072 SGTC_2567 aureobasidin a 60 nM 0.877301684614734 0.228994738556775 no 794 0.190161398737313 894 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1942 st076330 65.2 µM 0.876107254625317 0.229298672268639 no 795 0.190485864636632 972 24208414 SGTC_284 0988-0104 32.6 µM 0.875326199990391 0.229497541050024 no 796 0.190698221179948 975 4666532 SGTC_499 genistein 192 µM 0.874799836126464 0.229631616054883 no 797 0.190841413203483 947 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.87358901395201 0.229940202256062 no 798 0.191171055592386 873 6857784 SGTC_2370 9071495 200 µM 0.873331936635973 0.230005750004199 no 799 0.191241088955573 882 21791103 SGTC_1809 st050081 57.6 µM 0.87321283970413 0.23003612003799 no 800 0.19127353883896 940 5036894 SGTC_3085 9117376 49.47 µM 0.872482204052897 0.23022248317132 no 801 0.191472686183116 936 16480349 SGTC_168 3970-0862 530.542 µM 0.870715391740322 0.230673492569387 no 802 0.191954786130294 1050 3135186 SGTC_1657 st012939 43.4 µM 0.870382939631744 0.230758411864871 no 803 0.192045583412736 916 24207257 SGTC_3078 9116413 49.47 µM 0.869916857144982 0.23087749418641 no 804 0.192172921247447 942 17177322 SGTC_1260 0700-1617 7.75 µM 0.869910615427019 0.230879089154672 no 805 0.192174626890116 942 2853078 SGTC_2388 9080168 200 µM 0.869769806847485 0.230915072103885 no 806 0.19221310739884 878 15943073 SGTC_93 0109-0045 59.227 µM 0.868790167794238 0.231165500763228 no 807 0.192480955973166 1094 88733 SGTC_768 0384-0033 77.3 µM 0.868443188603361 0.231254236633347 no 808 0.192575880185493 934 3965305 YMR134W ERG29 SGTC_72 0744-0168 198.391 µM 0.867730185691349 0.231436638417388 no 809 0.192771028472927 909 677577 SGTC_2096 5468907 200 µM 0.867346180006298 0.23153490872196 no 810 0.192876180541361 965 759785 SGTC_1977 st070720 65.3 µM 0.86697604644704 0.231629651043543 no 811 0.19297756716632 899 682188 SGTC_1235 benzylparaben 21.5 µM 0.865754796155483 0.231942405157204 no 812 0.193312321647717 910 7180 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.865563368253446 0.231991449886172 no 813 0.193364825675702 929 756377 SGTC_2267 7931562 200 µM 0.864766815275905 0.232195592498979 no 814 0.193583394244693 848 934880 SGTC_26 0302-0163 425.158 µM 0.863997627901618 0.232392816626702 no 815 0.193794596820447 973 3100915 SGTC_2809 7964133 12.99 µM 0.862884446845666 0.232678407673054 no 816 0.194100501409546 927 1253665 SGTC_282 k297-0036 65.7 µM 0.862118996790802 0.232874900075231 no 817 0.194311019337585 947 5061378 SGTC_527 4476-4215 268 µM 0.861144450011912 0.233125201321522 no 818 0.194579245191468 931 4418754 SGTC_1175 0741-0056 27.6 µM 0.860759071935733 0.233224222488451 no 819 0.194685375468312 1030 765927 SGTC_517 1365-0151 113 µM 0.859804069503983 0.233469706652838 no 820 0.194948527821271 922 768657 SGTC_2176 5809774 33.9695 µM 0.85899125733913 0.23367875354629 no 821 0.195172669720717 995 2870539 SGTC_1648 st011736 69.8 µM 0.857977414864253 0.23393964873767 no 822 0.195452467352919 943 2855514 SGTC_105 0111-0055 734.78 µM 0.857941992590639 0.233948766976578 no 823 0.195462247503303 856 5179370 SGTC_1477 0139-0234 16 µM 0.855913206417853 0.234471336243114 no 824 0.196022894750341 976 620880 SGTC_1518 st038567 90.8 µM 0.852725134737509 0.235293814310163 no 825 0.196905874488605 956 77966 SGTC_1703 st026983 48.3 µM 0.852652546487255 0.235312559594461 no 826 0.19692600678686 1010 1104023 SGTC_926 2268-1401 59.4 µM 0.85092282498052 0.235759488934381 no 827 0.197406112347424 1010 2931578 SGTC_2109 5483026 200 µM 0.849726010268171 0.236068998378891 no 828 0.197738716995914 982 759335 SGTC_256 clotrimazole 625 nM 0.848843952196526 0.236297251516713 no 829 0.197984064812372 952 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_830 4076-0286 57.8 µM 0.846450885806124 0.236917125011461 no 830 0.198650630810901 1063 6866659 SGTC_2689 tacrolimus 100 µM 0.843580587793097 0.237661792925161 no 831 0.199451907816155 952 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_439 amiodarone 34.4 µM 0.843340756691185 0.237724072603725 no 832 0.199518947413292 978 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_611 3453-1652 23.7 µM 0.84323123803958 0.23775251553891 no 833 0.199549565493747 1015 1560575 SGTC_2334 9017922 200 µM 0.841988435290778 0.238075412843146 no 834 0.19989721338785 1007 3163164 SGTC_829 1635-0120 117 µM 0.841213513206669 0.238276869883131 no 835 0.200114165760209 1025 285054 SGTC_1960 st011366 51.8 µM 0.83979892083317 0.238644863152387 no 836 0.200510569320987 1037 3972846 SGTC_940 3232-1287 54.8 µM 0.839763513724586 0.238654077975888 no 837 0.200520497308873 991 1585493 YIL048W NEO1 SGTC_3171 9103192 49.47 µM 0.838109886670016 0.239084657010059 no 838 0.20098449538634 1051 13018434 SGTC_1901 st060216 58.6 µM 0.836972573178142 0.239381042216883 no 839 0.201303992413461 1035 688792 SGTC_1763 st044482 94.5 µM 0.836841495196571 0.239415214182203 no 840 0.201340834734031 998 88505 SGTC_1987 st072290 61.9 µM 0.835726157316265 0.23970608996741 no 841 0.20165448821158 1011 54697379 SGTC_3122 9126309 49.47 µM 0.835109200782248 0.239867072639388 no 842 0.201828113365381 1060 17591206 SGTC_889 0919-1524 82.7 µM 0.834906234540332 0.239920045576648 no 843 0.201885252096569 943 3905452 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.834505382052358 0.240024684344958 no 844 0.201998127893361 1006 641818 YHR062C RPP1 SGTC_218 alverine citrate 93.75 µM 0.834436548294927 0.24004265525233 no 845 0.202017514546675 957 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2000 st075254 36.4 µM 0.833966174253464 0.240165478704199 no 846 0.202150022639239 956 17234175 SGTC_878 0828-0289 13.7 µM 0.83178416133011 0.240735690796804 no 847 0.202765392799009 976 745350 YLR208W SEC13 SGTC_2038 4100038 30.985 µM 0.830317597726719 0.24111935251488 no 848 0.203179620537371 959 3596803 SGTC_1702 st027038 51 µM 0.82843062977492 0.241613483107563 no 849 0.203713333019913 1006 5521182 SGTC_797 k781-0471 270 µM 0.826213114164466 0.242194874504032 no 850 0.204341605159597 1026 23738129 SGTC_3074 9116018 49.47 µM 0.823597706691494 0.242881559306413 no 851 0.205084089732638 985 17027303 SGTC_2556 citropten 84.59 µM 0.823177418502021 0.242992005671288 no 852 0.205203554150277 1055 2775 A potential DNA crosslinker. SGTC_311 1315-0136 58 µM 0.821479135431007 0.243438569305982 no 853 0.20568670194101 1005 6759207 SGTC_146 3448-8650 53.125 µM 0.821158001920461 0.243523061202311 no 854 0.205778137671561 1070 2891488 YIL048W NEO1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.819876096157845 0.243860495034524 no 855 0.206143372479883 1100 6708784 An antioxidant flavonoid SGTC_2022 5136654 200 µM 0.819194126922949 0.244040111385316 no 856 0.206337832600688 983 1713771 SGTC_2356 9061756 188.97 µM 0.819096150570767 0.244065922156733 no 857 0.206365778996297 1005 20104043 SGTC_1672 st016598 6.51 µM 0.818514665577745 0.244219138154124 no 858 0.206531685679063 960 4665860 YNL267W PIK1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.81801631849341 0.244350489323665 no 859 0.206673934679533 965 689007 SGTC_1381 2324-0066 62.1 µM 0.817429080444762 0.24450531866472 no 860 0.206841631301843 956 10885928 SGTC_718 1130-0073 349 µM 0.816362915522863 0.244786555391279 no 861 0.207146300081754 1035 6740020 SGTC_2838 9002687 71.43 µM 0.812441324528691 0.2458225029397 no 862 0.208269221032102 950 6457060 SGTC_1141 3253-0389 52.6 µM 0.809829949025994 0.246513640384999 no 863 0.20901895859788 1034 5402031 SGTC_652 0437-0092 114 µM 0.809478193862286 0.24660681685996 no 864 0.209120070412836 1014 3091274 SGTC_1378 2093-0007 380 nM 0.809271951838742 0.246661457110231 no 865 0.209179367952331 994 3618014 SGTC_1256 0570-0116 285 µM 0.808618041371936 0.246834742216563 no 866 0.209367442026742 999 410638 SGTC_2135 5326629 150.42 µM 0.807309471425695 0.247181706507936 no 867 0.209744104278519 982 5020077 SGTC_2665 lovastatin 100 µM 0.806625334383362 0.247363207633641 no 868 0.209941186600033 1040 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_115 0527-0192 112.043 µM 0.806383996824025 0.247427251329078 no 869 0.210010735714972 1065 4233931 SGTC_493 zm226600 134 µM 0.80633248835012 0.247440921268943 no 870 0.210025581277413 1031 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2047 4141938 200 µM 0.805764318385838 0.247591735841367 no 871 0.210189377818522 981 3807862 SGTC_1441 4106-0040 13 µM 0.80538481135217 0.247692499225341 no 872 0.210298826897137 1047 2904180 SGTC_544 k015-0020 52.4 µM 0.803793801841239 0.24811516838361 no 873 0.210758034985892 1007 3008304 SGTC_2401 5128683 200 µM 0.80165790459771 0.248683197333747 no 874 0.211375436209194 1016 708373 SGTC_3334 9142812 21.919 µM 0.800876072003665 0.248891294005725 no 875 0.211601696871554 1001 45283678 SGTC_2131 toluylene red 5.2905 µM 0.800223446832337 0.249065071101124 no 876 0.211790673709316 1000 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2119 5528445 120.635 µM 0.798067588428344 0.249639578583209 no 877 0.212415634474577 1026 791935 SGTC_447 ml7 120 µM 0.79778681129352 0.249714453714102 no 878 0.212497108054716 1072 4216 Selective myosin light chain kinase inhibitor. SGTC_1906 st060206 94.7 µM 0.796184975047045 0.250141845054403 no 879 0.212962264632376 1073 5133468 SGTC_2735 sertaconazole 140 nM 0.794194605312724 0.25067344242329 no 880 0.213541074302322 1044 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_869 0564-0080 44.1 µM 0.793526427771936 0.250852036501076 no 881 0.2137355890761 1001 6843321 SGTC_2869 9037858 32.47 µM 0.793471159184001 0.250866812001353 no 882 0.213751683067802 1045 27187042 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.792398721245258 0.251153608657085 no 883 0.214064112404941 975 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2484 5809818 12.04 µM 0.792317985973689 0.25117520629948 no 884 0.214087643462255 1007 2870548 SGTC_745 0469-0705 296 µM 0.791444284034277 0.251408994747333 no 885 0.214342388419252 1141 3486736 SGTC_2409 alverine citrate 63.97 µM 0.789044235450869 0.25205180021337 no 886 0.215043076371157 1043 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2469 5655019 90.81 µM 0.788686305135633 0.252147739003904 no 887 0.215147687043316 1113 2788239 SGTC_1051 3253-3903 78 µM 0.788485897126157 0.252201464300295 no 888 0.215206272283014 1088 5509239 SGTC_566 0958-0068 16.5 µM 0.788297539790319 0.252251964559874 no 889 0.215261343191312 1016 6815365 SGTC_2614 arthonioic acid 13.39 µM 0.788102018814884 0.252304391093791 no 890 0.215318517216208 1039 6710684 SGTC_2667 digitoxin 100 µM 0.78808692762443 0.252308437848854 no 891 0.215322930531515 1022 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2923 7992654 58.14 µM 0.785089198170407 0.25311296743866 no 892 0.216200636251087 1036 2985126 SGTC_747 3448-8087 38.7 µM 0.782337514997904 0.253852649321233 no 893 0.217008122558826 1067 5168703 SGTC_3190 9110366 49.47 µM 0.781154320836035 0.254171053054902 no 894 0.217355868125186 985 17123768 SGTC_430 0958-0115 16.4 µM 0.779716870638795 0.254558160021274 no 895 0.217778773181319 985 6833180 SGTC_203 k066-0004 30.888 µM 0.778820290425719 0.254799766392222 no 896 0.218042791755118 1171 6795412 SGTC_199 4063-0024 41.6 µM 0.777618274932043 0.255123868332355 no 897 0.218397042089333 1105 306215 SGTC_606 k015-0008 38.6 µM 0.777192408158644 0.255238747382994 no 898 0.218522630313138 1140 1970475 SGTC_575 k072-0246 11.9 µM 0.777106164136034 0.255262015302275 no 899 0.218548068760638 1078 6796779 SGTC_2373 9071805 200 µM 0.776360559125816 0.255463219552454 no 900 0.218768062718812 1090 10149009 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.775572034875293 0.255676095840982 no 901 0.219000858773999 1148 23665772 A membrane-active detergent. SGTC_908 3448-7491 47.7 µM 0.775237095740636 0.255766546699546 no 902 0.219099785968717 1112 1203031 SGTC_2835 9006588 71.43 µM 0.773681749416685 0.256186789301546 no 903 0.219559507640045 1015 2345538 SGTC_2090 5301565 104.445 µM 0.773366261948654 0.256272075486766 no 904 0.219652825426941 1091 2056344 SGTC_1232 0279-0259 161 µM 0.770411825924076 0.257071470179016 no 905 0.220527820301522 1081 1560000 SGTC_1475 4092-1048 11.7 µM 0.767266688701573 0.257923886689776 no 906 0.221461484830115 1111 2881759 SGTC_1771 st048882 4.1505 µM 0.76683172675253 0.258041888357983 no 907 0.221590785151818 1093 4580403 SGTC_132 0417-1715 25.805 µM 0.764094102929848 0.258785225797275 no 908 0.222405583132155 1111 6769098 SGTC_2362 9071156 126 µM 0.761942599665722 0.259370192684179 no 909 0.223047131740044 1075 653133 SGTC_841 0251-0215 91.2 µM 0.76077311665868 0.259688446862134 no 910 0.223396297094347 1112 3888614 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.760569149465662 0.259743973572344 no 911 0.223457226160775 1154 66535 A nucleotide analog. SGTC_2354 9060492 162 µM 0.759363685309528 0.260072266411921 no 912 0.223817515319242 1120 6471895 SGTC_285 1486-1325 46 µM 0.757862804684485 0.260481310957965 no 913 0.224266559686968 1096 22310230 SGTC_2681 menadione 3.18 µM 0.755038579064967 0.261251912383041 no 914 0.225112917307021 1123 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1116 jasmonic acid  1.58368 µM 0.754667517962407 0.261353244896639 no 915 0.225224250411405 1113 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2816 7982706 58.44 µM 0.75347446736367 0.261679190024135 no 916 0.225582424355029 1082 2981853 SGTC_1005 4092-0690 4.4 µM 0.752237953707552 0.262017229387476 no 917 0.225953986575062 1067 1529343 SGTC_3061 glucosamine 200 µM 0.752095023387654 0.262056318252453 no 918 0.225996958263535 1075 91431 and experimental redox chemotherapeutic SGTC_1180 1193-0155 285 µM 0.751817264154531 0.262132288941188 no 919 0.226080479181485 1097 2921347 SGTC_1722 st034304 3.6505 µM 0.751544167421733 0.262206995378901 no 920 0.226162615113412 1140 4036148 YLR033W RSC58 SGTC_68 0986-0284 82.829 µM 0.751337165989831 0.262263628513829 no 921 0.226224883610854 988 423278 YIL048W NEO1 SGTC_2012 4023501 200 µM 0.750531958372331 0.262483983337217 no 922 0.226467191757834 1075 3477460 SGTC_2863 9028737 58.44 µM 0.749689506428815 0.262714631935091 no 923 0.226720864499763 1108 6460917 SGTC_2136 5328288 199.296 µM 0.749295346488083 0.262822581620663 no 924 0.226839605990473 1042 262395 SGTC_1514 1189-1591 158 µM 0.748005060180991 0.263176114541124 no 925 0.227228552679896 1125 767698 YMR146C TIF34 SGTC_3066 9117245 49.47 µM 0.747153637266453 0.263409533748814 no 926 0.227485413139612 1159 17176980 SGTC_2676 harmalol 100 µM 0.746869737933094 0.263487388779317 no 927 0.22757109729723 1117 5459187 A monoamine oxidase inhibitor SGTC_3033 9090887 49.47 µM 0.746779415511454 0.263512160778278 no 928 0.227598361476439 1142 19325384 SGTC_1408 3909-7976 48.8 µM 0.744036403677541 0.264265030153143 no 929 0.228427225947393 1167 24152374 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.742331784093281 0.264733445145298 no 930 0.228943169497757 1106 2724278 An inhibitor of dopamine biosynthesis. SGTC_2417 cerulenin 830 nM 0.740480984812862 0.26524250669448 no 931 0.229504097499029 1122 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_766 1391-0721 126 µM 0.739939149143288 0.26539163235598 no 932 0.229668459078276 1134 1020919 YIL115C NUP159 SGTC_78 0336-0123 156.75 µM 0.739657876790789 0.265469061761948 no 933 0.229753806818416 1002 6765896 SGTC_2246 7293507 91.5585 µM 0.738993301980184 0.265652053216855 no 934 0.22995553229545 1151 887656 SGTC_391 gliotoxin 8.33 µM 0.736546883956226 0.266326227961665 no 935 0.230698973141158 1146 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2483 5729050 27.16 µM 0.735022821905899 0.266746660567241 no 936 0.231162797618173 1159 2865180 SGTC_508 roscovitine 141 µM 0.731299817924708 0.267775108935146 no 937 0.232298020840706 1161 160355 A CDKinase inhibitor. SGTC_389 tpck 16.7 µM 0.729463087806329 0.268283225017799 no 938 0.232859219538576 1122 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_996 3970-0799 1.8 µM 0.729360790286987 0.268311539027067 no 939 0.232890497883479 1274 6615648 YGL040C HEM2 SGTC_2884 9058502 51.95 µM 0.728706292683331 0.26849272709085 no 940 0.233090671371398 1151 6471554 SGTC_50 0929-0078 56.389 µM 0.728652182488776 0.268507709457216 no 941 0.233107224868062 1045 1377751 SGTC_74 000s-0487 160.283 µM 0.727512977781226 0.268823237062059 no 942 0.233455884086124 1145 677548 SGTC_3165 9101544 49.47 µM 0.727014741023359 0.268961293112726 no 943 0.233608462779147 1133 5002184 SGTC_1080 nisoldipine 24.4 µM 0.72610562198974 0.269213291916088 no 944 0.233887011403413 1156 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1293 1000-1278 195 µM 0.725977154760879 0.269248911309471 no 945 0.233926387827396 1163 678847 SGTC_2560 caryophyllene 100 µM 0.725311934224803 0.269433391106396 no 946 0.234130342968776 1206 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_261 5-fluorouridine 15.376 µM 0.723835269194793 0.269843128020122 no 947 0.234583436890862 1160 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2245 6637752 200 µM 0.723103469686175 0.270046299278639 no 948 0.234808158888682 1115 681890 SGTC_1555 citronellol 128 µM 0.721849434019243 0.270394638083649 no 949 0.235193526412804 1140 8842 A terpine precursor. SGTC_825 1988-2224 89.6 µM 0.721136665721836 0.270592726805036 no 950 0.235412717029073 1137 1180859 SGTC_2539 epi(13)torulosol 80 µM 0.720827217461228 0.270678749557416 no 951 0.235507913692399 1146 6708597 SGTC_2379 9035213 200 µM 0.720338406433491 0.270814660736729 no 952 0.235658331624832 1173 646551 SGTC_2254 7938975 95.19 µM 0.719056534680352 0.27117123974374 no 953 0.236053043395942 1180 2969277 SGTC_1921 5740136 50 µM 0.716246822042377 0.271953637127276 no 954 0.236919478172972 1166 1774243 SGTC_905 2-aminofluorene 215 µM 0.714569863029984 0.27242114046159 no 955 0.237437436185357 1221 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2184 6075246 200 µM 0.714188738796698 0.272527446074064 no 956 0.237555239683293 1169 2267320 SGTC_3312 9133330 71.43 µM 0.712341729555523 0.273042917308757 no 957 0.238126594683635 1204 17617324 SGTC_444 curcumin 90.4 µM 0.711256425351212 0.273346033911274 no 958 0.238462674297716 1120 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3240 9133527 49.47 µM 0.710763808166277 0.273483672834092 no 959 0.238615305739781 1148 17617455 SGTC_834 0312-0008 75.7 µM 0.709704452302824 0.273779776644685 no 960 0.238943715307059 1187 6385573 YIL048W NEO1 SGTC_981 1488-1094 54.9 µM 0.709238436636393 0.273910084311006 no 961 0.239088262471173 1154 3449522 SGTC_556 4058-0063 51.5 µM 0.707437455407868 0.274413964117525 no 962 0.239647333762602 1227 6615692 SGTC_2361 9034121 116 µM 0.706133266029715 0.274779136531159 no 963 0.240052632986541 1160 6496917 SGTC_148 3253-0744 288.01 µM 0.705670723483422 0.274908705752615 no 964 0.240196465740525 1174 6893655 SGTC_123 0083-0120 66.675 µM 0.705464952307303 0.274966356851648 no 965 0.240260467670248 1135 16001701 SGTC_702 1488-0190 94 µM 0.704899451238881 0.27512482447775 no 966 0.240436405848983 1182 949357 SGTC_1306 1185-0270 9.02 µM 0.704494866262321 0.275238226958864 no 967 0.240562323006796 1191 1548076 SGTC_794 k038-0031 316 µM 0.702300578315534 0.275853671818864 no 968 0.241245866346494 1222 6624242 SGTC_1898 st060199 18.6 µM 0.700830752616135 0.276266300277834 no 969 0.241704321891945 1216 688866 SGTC_614 0462-0418 107 µM 0.700750376727704 0.276288873166057 no 970 0.241729405686314 1085 5188303 SGTC_2238 6671620 73.2395 µM 0.698356245362397 0.276961659310603 no 971 0.242477216246927 1180 729941 SGTC_2784 7567673 72.73 µM 0.698209894810586 0.277002811968591 no 972 0.242522969670768 1228 3471247 SGTC_893 0958-0369 48.9 µM 0.696747269166023 0.277414255496258 no 973 0.242980485608684 1206 6819948 SGTC_195 4234-0266 16.654 µM 0.695795964136399 0.277682022368745 no 974 0.243278308540865 1191 2303354 SGTC_2142 5622915 118.518 µM 0.695774551427787 0.277688050924863 no 975 0.243285014439354 1173 5322196 SGTC_3160 9100216 49.47 µM 0.695009002819195 0.277903626260979 no 976 0.243524829801906 1161 17191039 SGTC_1012 4112-3522 18 µM 0.694628451957087 0.278010818204174 no 977 0.243644088464788 1203 3112398 SGTC_546 peri-Naphthalide 147 µM 0.694400578450841 0.278075014296623 no 978 0.243715515535391 1152 223824 A penicillin ester. SGTC_1802 st050112 57.9 µM 0.69355907504149 0.278312143684396 no 979 0.243979383149767 1202 4662563 SGTC_608 k048-0125 159 µM 0.691858614921977 0.278791621303406 no 980 0.244513061215568 1223 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_377 3970-0964 33.1 µM 0.691676761037948 0.2788429223106 no 981 0.244570172043438 1207 16481235 SGTC_1489 4065-0444 182 µM 0.690437251550136 0.27919271042795 no 982 0.244959628687124 1181 2877968 SGTC_2999 9069765 71.4286 µM 0.69012293741106 0.279281443395008 no 983 0.245058439899998 1214 2097066 SGTC_1943 st076331 65.2 µM 0.68986461983099 0.279354378419666 no 984 0.245139663473291 1267 24208415 SGTC_782 0083-0095 30.5 µM 0.689741244395694 0.27938921628783 no 985 0.245178461890409 1226 3591729 An indicator and reagent. SGTC_1957 st077035 62.4 µM 0.6895513370068 0.27944284509468 no 986 0.24523818935687 1263 705593 SGTC_3280 9140961 49.47 µM 0.688096053790613 0.279853974978408 no 987 0.245696147683331 1193 4901226 SGTC_2581 avocatin a 64 µM 0.688079799314617 0.279858568662341 no 988 0.245701265343243 1214 6710728 A skin care supplement. SGTC_2949 9072542 2.23 µM 0.687697546795872 0.279966607740596 no 989 0.245821632593059 1231 16457352 SGTC_2518 prenyletin 46.28 µM 0.686918038443938 0.280186989050545 no 990 0.24606718953313 1136 3873459 A coumarin with calcium channel inhibitory activity. SGTC_519 k048-0011 62.8 µM 0.68689492875531 0.280193523866065 no 991 0.2460744714429 1194 6836379 SGTC_1572 epiandrosterone 68.9 µM 0.685865918858435 0.28048457577394 no 992 0.246398831684235 1172 441302 A steroid. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.685039385144275 0.280718463920326 no 993 0.246659534074763 1224 16623 A steroid. SGTC_941 3237-0776 460 µM 0.684811261807154 0.280783033664335 no 994 0.246731513948698 1207 760008 SGTC_325 2810-4341 181 µM 0.684763784571468 0.280796472880823 no 995 0.246746495879147 1216 774970 SGTC_167 3672-0051 66.205 µM 0.684375226295285 0.280906472412576 no 996 0.246869127746742 1186 3237971 SGTC_1896 st058441 89 µM 0.68295592609369 0.281308448394295 no 997 0.247317346465772 1168 688759 SGTC_1380 2291-0730 164 µM 0.681441664162984 0.281737625490433 no 998 0.247796033610967 1206 2999191 SGTC_1857 st056007 79.3 µM 0.681353337443758 0.281762669078878 no 999 0.247823970635336 1234 619834 SGTC_2714 st079313 56.9 µM 0.679129969746941 0.282393421614652 no 1000 0.248527757322073 1221 2939799 SGTC_2920 7982904 15.77 µM 0.678115240855986 0.28268151804807 no 1001 0.248849314018147 1200 6456808 SGTC_395 anisomycin 6.25 µM 0.677284701990466 0.282917425291346 no 1002 0.24911266760115 1184 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1269 0831-0796 3.05 µM 0.677229258288693 0.282933176951492 no 1003 0.249130253389251 1217 927758 SGTC_1827 berberine 7.24 µM 0.676227190028279 0.283217938988813 no 1004 0.249448205985389 1153 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_668 1682-0499 62.6 µM 0.675295970497722 0.283482690823776 no 1005 0.249743871749427 1248 682214 SGTC_34 0469-0683 81.75 µM 0.672465655760225 0.28428809523929 no 1006 0.2506436486178 1229 3690923 SGTC_1688 st021091 57.6 µM 0.67169421323774 0.284507809202798 no 1007 0.250889193046229 1240 3656366 SGTC_549 1661-1316 519 µM 0.669419252980514 0.285156210760018 no 1008 0.251614036745092 1267 2857282 SGTC_1122 capsaicin 818.572 nM 0.669287020537558 0.285193920856546 no 1009 0.251656202397304 1278 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2693 st077581 40.7 µM 0.668175948656109 0.285510870581795 no 1010 0.252010643087491 1254 25238761 SGTC_2728 chlorpromazine 9.18 µM 0.666703570344509 0.285931146481902 no 1011 0.252480748885658 1249 2726 A thorazine and dopamine antagonist. SGTC_102 gallobenzophenone 83.616 µM 0.665691194178511 0.286220289813701 no 1012 0.252804251583449 1296 70837 SGTC_2638 epoxomicin 18 µM 0.665215133658659 0.286356304773366 no 1013 0.252956451134173 1236 9915668 A protesome inhibitor. SGTC_2084 5306078 60.6385 µM 0.663463937778935 0.286856901714997 no 1014 0.253516734171267 1195 679340 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.663200282847451 0.286932306031131 no 1015 0.253601145185321 1259 5282362 SGTC_1303 1160-0052 261 µM 0.661470342558182 0.287427295229516 no 1016 0.254155363974776 1266 3562476 SGTC_727 3032-0951 202 µM 0.6612337711827 0.287495016965585 no 1017 0.254231203390617 1236 3652836 SGTC_503 tyrphostin 8 294 µM 0.658871314528225 0.288171715474825 no 1018 0.254989203831879 1218 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2737 bleomycin 30.5 nM 0.657828180359232 0.288470748209826 no 1019 0.25532427211137 1274 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1989 st071868 50.2 µM 0.655889399256984 0.289026922040662 no 1020 0.255947644702527 1246 16414057 SGTC_1564 D-Arginine 115 µM 0.65530748918814 0.289193951654012 no 1021 0.256134899962682 1216 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_400 oxethazaine 37.5 µM 0.655176130541131 0.289231662699075 no 1022 0.256177180289781 1245 4621 A local anesthetic. SGTC_2236 dapsone 200 µM 0.652739291029512 0.289931660633459 no 1023 0.256962183791058 1273 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2810 7959871 45.46 µM 0.651978877234513 0.290150256940585 no 1024 0.257207399438698 1261 2974535 SGTC_1665 st014639 11.4 µM 0.648890583005684 0.291038842284241 no 1025 0.258204550980703 1323 981133 YIL048W NEO1 SGTC_2587 piperic acid 92.2 µM 0.648633959889591 0.291112736829731 no 1026 0.258287499797875 1234 5370536 SGTC_1425 4048-4433 7.33 µM 0.648520043055926 0.291145541954012 no 1027 0.258324325795611 1311 23734946 SGTC_1107 amlodipine 47 µM 0.647300636804602 0.291496807749399 no 1028 0.258718694735406 1170 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_96 0929-0093 37.281 µM 0.646521608718519 0.29172132032508 no 1029 0.258970803739763 1245 6991579 SGTC_2043 5101342 149 µM 0.643799356124559 0.292506494059831 no 1030 0.259852775677257 1260 678451 SGTC_2911 7942208 15.64 µM 0.642057209290857 0.293009492754818 no 1031 0.26041801908493 1247 1243384 SGTC_814 3342-0569 96 µM 0.640364828559509 0.293498506725908 no 1032 0.260967721541897 1313 4346283 SGTC_748 act1.228 77.9 µM 0.639571403200334 0.293727897316872 no 1033 0.261225639444384 1233 4421505 YNR035C ARC35 SGTC_3291 9121177 71.43 µM 0.638671882971475 0.293988061754598 no 1034 0.261518203826329 1239 17015612 SGTC_2970 9090938 41.86 µM 0.638049360959914 0.294168173525076 no 1035 0.261720774392961 1282 17217104 SGTC_511 blebbistatin 171 µM 0.637744351758323 0.294256439207423 no 1036 0.261820054697674 1340 3476986 A myosin inhibitor. SGTC_2465 5809242 33.21 µM 0.637681753029177 0.294274555975581 no 1037 0.261840432933801 1285 2731748 SGTC_3002 9075603 71.4286 µM 0.637188555312146 0.294417310894129 no 1038 0.262001015752731 1265 20105405 SGTC_1386 3228-0095 33.8 µM 0.635563451319543 0.294887919491771 no 1039 0.262530498870234 1293 870181 SGTC_2347 9049783 174.81 µM 0.634208557538012 0.295280543605663 no 1040 0.262972361765412 1299 6467988 YPL169C MEX67 SGTC_649 1123-0311 367 µM 0.628022618807571 0.297076167717195 no 1041 0.264994561374358 1297 693629 YIL048W NEO1 SGTC_2496 diffractaic acid 79.83 µM 0.627720924448843 0.29716386964912 no 1042 0.265093387740348 1375 94870 An apoptosis inducer which activates caspases. SGTC_2979 9012552 45.46 µM 0.627637253454834 0.29718819473196 no 1043 0.265120799259104 1350 17100905 SGTC_2302 7771753 200 µM 0.627436830120677 0.297246466107061 no 1044 0.265186465955757 1268 2203047 SGTC_2320 7373003 200 µM 0.627360266992666 0.297268727561829 no 1045 0.265211553277297 1279 5415828 SGTC_2643 anethole 100 µM 0.626562237553969 0.297500807523359 no 1046 0.265473114069678 1285 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1975 st070967 30.8 µM 0.626089569378551 0.297638306128337 no 1047 0.265628096692976 1306 261391 SGTC_2788 5282734 71.43 µM 0.625762445623655 0.297733483013997 no 1048 0.265735383784023 1375 743706 SGTC_2749 bexarotene 57.39 µM 0.625242588238429 0.297884764443031 no 1049 0.265905927092883 1278 82146 An retinoic acid receptor inhibitor. SGTC_3321 9137793 26.8275 µM 0.62491903697988 0.297978937374434 no 1050 0.266012098624 1295 4904192 SGTC_507 nimesulide 162 µM 0.620590622376542 0.299240069954843 no 1051 0.267434505660263 1354 4495 A COX2 inhibitor. SGTC_166 k072-0058 166.424 µM 0.619700917993705 0.299499595155233 no 1052 0.267727355595618 1302 5846229 SGTC_2174 5790901 200 µM 0.617314117713847 0.300196324057324 no 1053 0.26851377834609 1317 786020 SGTC_2201 6605497 169.863 µM 0.617155990904273 0.300242508597081 no 1054 0.268565920265132 1318 670741 SGTC_274 sirtinol 40.1 µM 0.6166384834343 0.300393680905323 no 1055 0.268736602630895 1287 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3197 9113331 49.47 µM 0.612962982303307 0.3014683422837 no 1056 0.269950408332398 1385 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2259 7964009 200 µM 0.610258170554985 0.302260292033094 no 1057 0.270845400639018 1349 313134 SGTC_2237 6667747 47.222 µM 0.609539104021343 0.3024709866 no 1058 0.271083580753069 1335 729940 YDL015C TSC13 SGTC_701 4424-0219 185 µM 0.609443638916571 0.302498963898309 no 1059 0.271115210004995 1355 2911779 SGTC_3351 9150312 21.596 µM 0.609234371441689 0.302560296529095 no 1060 0.271184550402428 1326 4904905 SGTC_2133 5320837 200 µM 0.608957167689004 0.302641548673186 no 1061 0.271276414973741 1341 2841355 SGTC_836 0330-0104 1.35 µM 0.60839346957866 0.302806806310896 no 1062 0.271463270826651 1336 46494820 SGTC_2024 5144227 134 µM 0.607591862180324 0.303041880644664 no 1063 0.271729099726664 1325 3475211 SGTC_3234 9132280 49.47 µM 0.605627648846432 0.303618238314341 no 1064 0.272381019021026 1323 17612295 SGTC_2822 7994718 71.43 µM 0.604378752318336 0.303984955413958 no 1065 0.272795929445434 1329 1018011 SGTC_2506 ethyl hematommate 54.16 µM 0.603619041847347 0.304208127950052 no 1066 0.273048474967823 1287 3940691 An allergen. SGTC_2620 irigenin 100 µM 0.601557334323514 0.304814142576993 no 1067 0.273734418222579 1404 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2006 4011487 200 µM 0.600341223212053 0.305171855502604 no 1068 0.274139425421682 1408 45595294 SGTC_609 0986-0026 86.3 µM 0.5998981805704 0.30530222054151 no 1069 0.274287047525413 1376 2848610 SGTC_41 0478-0632 82.643 µM 0.599120319301259 0.305531165511173 no 1070 0.274546326335945 1328 3750424 SGTC_2445 5742597 35.57 µM 0.598547379175904 0.305699845466457 no 1071 0.274737377580185 1311 1774255 SGTC_3032 9089427 49.47 µM 0.596889956819181 0.306188041171084 no 1072 0.275290426504061 1304 17173707 SGTC_3146 9095609 49.47 µM 0.59533631513159 0.306645980903722 no 1073 0.275809342958755 1403 17173999 SGTC_1352 1496-0991 99 µM 0.59338566273508 0.30722136813746 no 1074 0.276461540849699 1343 3000039 SGTC_2453 5731132 22.18 µM 0.5927212274597 0.307417466241042 no 1075 0.276683866395537 1424 1362040 SGTC_612 0302-0167 22.4 µM 0.589260231018557 0.308439816815034 no 1076 0.27784335918307 1419 235821 SGTC_962 1254-0300 21.5 µM 0.587472542620723 0.308968468656281 no 1077 0.278443192939115 1371 7340576 SGTC_3270 9137563 49.47 µM 0.584013779824049 0.309992410902831 no 1078 0.279605520561662 1377 17015724 SGTC_3303 9125618 40.5795 µM 0.583013802356234 0.310288722460761 no 1079 0.279942004364483 1443 22695467 SGTC_3004 9076122 71.4286 µM 0.58099179615646 0.310888256029084 no 1080 0.280622991346992 1395 44782551 SGTC_2591 skatole 100 µM 0.580944514567452 0.310902281241046 no 1081 0.280638924793422 1380 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2601 securinine 100 µM 0.580590147265303 0.311007406513763 no 1082 0.280758357139437 1329 442872 A GABA receptor antagonist. SGTC_1153 4055-0057 267 µM 0.579538901724782 0.311319355784474 no 1083 0.281112802775071 1335 882706 SGTC_1770 st043884 66.3 µM 0.576890123386655 0.31210596163127 no 1084 0.282006841480712 1361 670149 SGTC_1816 st051957 91.6 µM 0.576624997309601 0.312184743202207 no 1085 0.282096404481624 1385 674121 SGTC_189 3970-0742 2.116 µM 0.576608778343125 0.312189562907591 no 1086 0.282101883901737 1395 2891807 SGTC_1008 4106-0037 6 µM 0.574718211779594 0.312751592743005 no 1087 0.282740944299847 1367 2905394 SGTC_1053 3366-3204 134 µM 0.573587431408156 0.313087960737653 no 1088 0.283123509450534 1323 3632071 YPR165W RHO1 SGTC_1780 st038448 24.544 µM 0.573429763495383 0.313134873848342 no 1089 0.283176871318809 1463 728868 YDL195W SEC31 SGTC_2456 5770359 74.46 µM 0.573012610851818 0.313259009620615 no 1090 0.283318077684063 1435 3118787 SGTC_1413 3910-0535 34.4 µM 0.570519113049239 0.314001462565866 no 1091 0.284162831240561 1437 2876951 SGTC_2709 st078560 56 µM 0.570391102228126 0.314039598865538 no 1092 0.284206231557842 1452 17250903 SGTC_342 k048-0088 23.3 µM 0.566617175813745 0.315164797755576 no 1093 0.285487151514381 1349 6820570 SGTC_2533 agelasine 13.65 µM 0.566593457311633 0.315171874884151 no 1094 0.285495210567719 1478 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2295 7971645 200 µM 0.566494383655306 0.31520143722318 no 1095 0.28552887490501 1450 2978226 YKL099C UTP11 SGTC_957 1187-1561 14.1 µM 0.566091847560895 0.315321561126172 no 1096 0.285665672480802 1363 1538454 SGTC_2114 5491910 81.25 µM 0.56508804258582 0.315621199350195 no 1097 0.286006940612649 1459 2849228 SGTC_1915 st067105 30.6 µM 0.56494090653406 0.315665130012543 no 1098 0.286056979400859 1348 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1446 4239-0190 62 µM 0.563079878538909 0.316221004973111 no 1099 0.286690246193392 1375 1340085 SGTC_2776 terbinafine 19.92 µM 0.562003712551994 0.316542637342875 no 1100 0.287056744825753 1378 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3095 9117207 49.47 µM 0.559440330939277 0.317309310614514 no 1101 0.287930621529536 1377 17015229 SGTC_2325 6158266 200 µM 0.559019859476952 0.317435143011685 no 1102 0.28807408334753 1399 3623240 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.558638893134632 0.317549171129362 no 1103 0.288204095426018 1442 364106 SGTC_870 0573-2213 57.6 µM 0.557603487394033 0.3178591688061 no 1104 0.28855758728429 1381 3916321 SGTC_2458 5808907 16.39 µM 0.555540198662903 0.318477292487953 no 1105 0.289262611179629 1427 2731747 SGTC_1844 rapamycin 4 nM 0.55470948227675 0.31872630283301 no 1106 0.289546694647808 1395 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1363 1636-0063 10.4 µM 0.553919565028801 0.318963159428249 no 1107 0.289816947319848 1416 6072185 SGTC_2154 5570129 200 µM 0.553636763770397 0.319047975333843 no 1108 0.289913730258061 1389 673366 SGTC_2232 chlorophetanol 41.5365 µM 0.552655863847852 0.319342233830675 no 1109 0.290249540570871 1474 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3212 9128307 49.47 µM 0.551641862302883 0.319646542083057 no 1110 0.290596874608479 1345 27243542 SGTC_1701 st028638 40.4 µM 0.549634492774964 0.320249324420011 no 1111 0.291285047842526 1479 3490878 SGTC_788 1182-0090 188 µM 0.548409327067641 0.320617456293293 no 1112 0.291705436761109 1553 5715185 SGTC_2061 5245884 80.95 µM 0.544803308735036 0.321701998530868 no 1113 0.292944401399962 1403 573863 SGTC_1550 gossypolone 36.6 µM 0.544019166875857 0.321938037867375 no 1114 0.293214141687388 1403 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2281 7943571 200 µM 0.5439969890908 0.321944714783459 no 1115 0.293221772391988 1476 1244024 SGTC_2817 7995342 71.43 µM 0.543390280195387 0.322127394826167 no 1116 0.29343055825934 1342 18879975 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.542479094764888 0.322401833489774 no 1117 0.293744252522577 1426 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_253 dyclonine 31.25 µM 0.542229315813603 0.322477080976162 no 1118 0.29383027114003 1472 3180 An oral anasthetic. SGTC_1941 st076221 61.8 µM 0.540581441065811 0.322973695798732 no 1119 0.294398056352384 1410 2828568 SGTC_1807 st050092 58.9 µM 0.539254029269294 0.323373963403774 no 1120 0.294855792143339 1397 5008496 SGTC_1121 fusaric acid 630.51 nM 0.539077854048035 0.323427102642863 no 1121 0.294916567876561 1408 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2073 5212005 126 µM 0.538939645681933 0.323468792566839 no 1122 0.29496425010198 1325 691789 SGTC_1066 ketoconazole 628 nM 0.538890498428554 0.323483618146108 no 1123 0.294981206881099 1487 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3131 9127911 49.47 µM 0.537777595367794 0.32381940736027 no 1124 0.295365300724793 1466 45595681 SGTC_3222 9128301 49.47 µM 0.537344836801247 0.323950019621607 no 1125 0.295514719871255 1419 4911358 SGTC_2878 9043973 25.97 µM 0.536611150357209 0.324171505422643 no 1126 0.295768120187888 1495 6465167 SGTC_484 loperamide 105 µM 0.531862890867812 0.325606415457449 no 1127 0.297410480342583 1420 3955 An opioid-receptor agonist. SGTC_3124 9127567 49.47 µM 0.530936124291311 0.32588678412003 no 1128 0.297731521859629 1531 17592030 SGTC_3247 9135149 49.47 µM 0.530718941312774 0.325952501323223 no 1129 0.297806779147513 1417 8934436 YOR116C RPO31 SGTC_448 monastrol 171 µM 0.529529929407379 0.326312379158844 no 1130 0.298218943991276 1455 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2840 9008771 71.43 µM 0.526655048394675 0.327183186337478 no 1131 0.299216578460117 1509 2992978 SGTC_1698 5-fluorocytosine 1.055 µM 0.525526190063513 0.327525377483925 no 1132 0.299608725877227 1485 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_776 4476-4378 112 µM 0.524821998463338 0.327738912713371 no 1133 0.299853468714539 1435 2892008 SGTC_3283 9109332 35.8195 µM 0.519803842906848 0.329262218802931 no 1134 0.301600150311315 1403 17027281 SGTC_1305 1181-0477 144 µM 0.51942588058423 0.329377067918569 no 1135 0.301731893722372 1530 6252086 SGTC_299 1273-0059 1.44 µM 0.518623711915057 0.329620871373553 no 1136 0.302011585156378 1449 2848077 SGTC_367 0335-0881 7.1 µM 0.51749094066399 0.329965278345681 no 1137 0.302406745681471 1524 23828853 SGTC_1237 0330-0133 46.1 µM 0.514935964208539 0.330742620559872 no 1138 0.303298884182331 1427 X1237 YHR072W ERG7 SGTC_2598 perillyl alcohol 100 µM 0.51299967037224 0.331332217677723 no 1139 0.303975775635163 1512 10819 An apoptosis inducer. SGTC_2931 9014674 55.67 µM 0.512642271156093 0.331441090710116 no 1140 0.304100789193531 1421 2996810 SGTC_1299 1079-1439 3.74 µM 0.512611329435258 0.331450517027617 no 1141 0.304111613279254 1413 323161 SGTC_423 5-fluorouracil 457 µM 0.509785550998914 0.332311832790388 no 1142 0.305100854748431 1398 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1348 1493-0373 93.8 µM 0.509279624064212 0.332466136318532 no 1143 0.305278119075356 1493 3010129 SGTC_980 1473-0395 201 µM 0.508657945519264 0.332655782011857 no 1144 0.305496002461408 1424 768876 SGTC_1882 5615643 20 µM 0.506696119759494 0.333254525998227 no 1145 0.306184026785265 1407 2253075 SGTC_80 0159-0065 512.242 µM 0.505407580462649 0.333648016205601 no 1146 0.306636297852156 1458 1548079 SGTC_2283 7944793 200 µM 0.503611362971187 0.334196845021714 no 1147 0.307267253014724 1403 2970533 SGTC_1531 st059297 52.4 µM 0.502660088255958 0.334487647871866 no 1148 0.307601637521968 1487 7566702 SGTC_984 1492-0255 2.91 µM 0.50182923775016 0.334741718550286 no 1149 0.307893822321281 1513 1585198 SGTC_2684 capsaicin 100 µM 0.501585514246883 0.334816262558949 no 1150 0.30797955557018 1459 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_8 0354-0001 70 µM 0.500061109335737 0.335282656737657 no 1151 0.308516024576426 1518 4993152 SGTC_616 4092-0450 108 µM 0.498419645934084 0.335785149179689 no 1152 0.309094146245241 1529 787165 SGTC_927 2425-1185 123 µM 0.498242937789675 0.335839261430482 no 1153 0.309156410898265 1434 730375 SGTC_562 3772-2733 112 µM 0.497178072796841 0.336165420521122 no 1154 0.309531741356742 1482 2876874 YIL048W NEO1 SGTC_3049 9092223 49.47 µM 0.496130294036752 0.336486466672489 no 1155 0.309901243477236 1480 8623917 SGTC_1075 aripiprazole 15.2 µM 0.496020301119181 0.336520176129742 no 1156 0.309940043936916 1477 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1766 st045414 44.774 µM 0.495815420190401 0.33658296935638 no 1157 0.310012322181449 1494 253960 SGTC_450 aminopyrene 156 nM 0.493786299125215 0.337205113271976 no 1158 0.310728555084275 1530 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1059 3448-6867 171 µM 0.493030147995787 0.337437068969775 no 1159 0.310995642732246 1502 3934407 SGTC_3133 9127736 49.47 µM 0.492118422497767 0.337716830570378 no 1160 0.311317814770472 1545 27243420 SGTC_2659 sanguinarine 24.21 µM 0.491981240607442 0.337758932394289 no 1161 0.311366302591797 1473 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_190 3970-0790 3.722 µM 0.49151632777605 0.337901631617203 no 1162 0.311530653356868 1546 2832352 SGTC_1607 st000305 50.6 µM 0.48762480868056 0.339096997142204 no 1163 0.312907809918317 1538 5457690 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.485090880354805 0.339876221423836 no 1164 0.313805940401126 1458 4174840 SGTC_2770 toltrazuril 17.5 µM 0.484440289620769 0.340076399278324 no 1165 0.314036715442432 1521 68591 Kills coccidiodes. SGTC_2937 9044753 11.33 µM 0.483964582512145 0.340222796379255 no 1166 0.314205502483259 1451 6465530 YGL099W LSG1 SGTC_2028 5153890 36.43 µM 0.48304190342253 0.340506816105607 no 1167 0.314532991736102 1491 2830968 YPR165W RHO1 SGTC_1403 3909-7815 62.9 µM 0.482327476550471 0.340726793646506 no 1168 0.314786665700873 1547 6615483 SGTC_1427 4048-4900 550 nM 0.482314815731496 0.340730692499037 no 1169 0.314791162009375 1585 24132586 SGTC_216 k038-0035 28.382 µM 0.482168396750126 0.340775782920716 no 1170 0.314843162607973 1473 4444231 YPR107C YTH1 SGTC_1972 st070201 17.4 µM 0.481187644418128 0.34107786889507 no 1171 0.315191570724442 1597 2829099 SGTC_3036 9090181 49.47 µM 0.481165914039321 0.341084563322198 no 1172 0.315199292212869 1522 25236586 SGTC_1866 st057638 64 µM 0.4805961685225 0.341260101339823 no 1173 0.315401769550608 1515 688802 SGTC_2229 7354935 190 µM 0.480384796888404 0.341325233465477 no 1174 0.315476901342498 1525 318112 SGTC_471 1-acyl-paf 4 µM 0.480244670930825 0.341368414530267 no 1175 0.315526713150254 1433 16759367 SGTC_521 r062-0005 13.8 µM 0.480177661906472 0.341389064693429 no 1176 0.315550534622917 1503 2832033 SGTC_3170 9103054 49.47 µM 0.479836432699055 0.341494228623437 no 1177 0.315671852294991 1447 16432970 SGTC_2998 9066762 71.4286 µM 0.479671005472924 0.341545216312956 no 1178 0.315730674006334 1607 4945196 SGTC_3050 9093513 49.47 µM 0.479514202505813 0.341593548518054 no 1179 0.315786433459738 1478 25236664 SGTC_470 aa-861 153 µM 0.478812966001966 0.341809726113558 no 1180 0.316035845869774 1478 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_645 0845-0943 5.41 µM 0.478593151954286 0.341877501199566 no 1181 0.316114045514706 1499 1885106 SGTC_1139 k015-0024 46.9 µM 0.478590561883071 0.341878299824493 no 1182 0.316114966990984 1532 2766652 SGTC_2936 9038235 15.59 µM 0.478002443454304 0.342059659113646 no 1183 0.316324232959705 1493 4749415 SGTC_1222 0366-0074 1.18 µM 0.475514661727818 0.342827224181746 no 1184 0.317210092697243 1622 286520 SGTC_1685 st024049 53.0905 µM 0.471855924518516 0.343957247628926 no 1185 0.318514814994141 1519 1941139 SGTC_176 1486-1328 72.834 µM 0.46970044335332 0.344623635027567 no 1186 0.319284525534843 1502 22310231 SGTC_2083 5306046 65.942 µM 0.467193604573467 0.345399254730897 no 1187 0.320180684436971 1506 539837 SGTC_2345 9052315 157.45 µM 0.466914230342733 0.345485733833036 no 1188 0.320280621837493 1548 6469265 SGTC_758 0868-0029 16 µM 0.466112069186463 0.34573408421318 no 1189 0.32056764235909 1644 762687 SGTC_1276 0871-0068 94.2 µM 0.465718811412451 0.345855861712593 no 1190 0.320708392768159 1600 3414906 SGTC_1355 1499-0035 1.68 µM 0.46492546926309 0.346101579186057 no 1191 0.320992415333287 1500 1548538 SGTC_3011 9081274 71.4286 µM 0.461117461934357 0.347281912765806 no 1192 0.32235716715268 1522 6625322 SGTC_687 k029-0044 34.9 µM 0.460871442588162 0.347358220267923 no 1193 0.322445420682963 1654 5829338 SGTC_3129 9127257 49.47 µM 0.460213707419586 0.347562259509593 no 1194 0.322681416502687 1421 837894 SGTC_1845 st056753 3.01 µM 0.456810594264792 0.348618660227269 no 1195 0.323903595141786 1479 5375839 SGTC_1329 1447-1697 50.6 µM 0.454766511911963 0.349253753474222 no 1196 0.324638612390702 1527 2840515 SGTC_752 1896-0090 130 µM 0.454015028871471 0.349487344374446 no 1197 0.324909004889705 1547 772567 SGTC_1681 tripelennamine 100 µM 0.452587345724808 0.349931282212218 no 1198 0.32542295625879 1494 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1777 st045864 34.765 µM 0.452443485255831 0.349976026992051 no 1199 0.325474762997404 1546 4691462 SGTC_937 3122-0005 46.7 µM 0.450548294616331 0.350565680552696 no 1200 0.326157569689687 1649 759535 SGTC_843 0310-0051 143 µM 0.450491576971739 0.350583332758819 no 1201 0.326178013143307 1579 2065037 SGTC_144 4161-2749 112.381 µM 0.450321215378268 0.350636356258102 no 1202 0.326239421854644 1480 797501 YMR168C CEP3 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.44927733130804 0.350961319206707 no 1203 0.326615804182382 1603 5393153 SGTC_2207 7258803 200 µM 0.448611093480892 0.351168777234599 no 1204 0.326856114890624 1597 3666799 SGTC_704 1310-0270 142 µM 0.44677598486218 0.351740436048084 no 1205 0.32751840623316 1520 5718033 SGTC_272 doxorubicin 8.13 µM 0.446773986161598 0.351741058850863 no 1206 0.327519127861371 1547 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2146 5545642 200 µM 0.446424365245549 0.351850008191946 no 1207 0.327645367945227 1558 825326 SGTC_486 niguldipine 82 µM 0.442870123674055 0.352958274866473 no 1208 0.328929839198535 1576 1236 A calcium channel blocker. SGTC_2717 st081029 62.2815 µM 0.441952076719732 0.353244739188862 no 1209 0.329261942538545 1607 5292846 SGTC_229 benomyl 22.8748 µM 0.440721407531118 0.353628883574442 no 1210 0.329707348309804 1540 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1308 1187-1617 41.4 µM 0.440343545771102 0.353746860296578 no 1211 0.329844153158055 1559 2882570 SGTC_197 4544-0043 41.561 µM 0.43994307138019 0.353871912511002 no 1212 0.329989169757824 1557 896523 SGTC_3332 9141069 11.198 µM 0.439675148536955 0.353955582955667 no 1213 0.330086202112715 1514 17332883 SGTC_451 chloral hydrate 100 µM 0.437939575271911 0.354497761115269 no 1214 0.330715043126806 1598 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_150 3970-0969 77.2 µM 0.436658431100996 0.354898168833124 no 1215 0.331179540100738 1607 6615640 SGTC_2268 7933382 153.85 µM 0.435701790380113 0.355197261100817 no 1216 0.331526553290514 1544 935025 YOR257W CDC31 SGTC_275 trichlorophene 5.69 µM 0.435603223087983 0.355228083088469 no 1217 0.331562315952824 1611 62616 SGTC_1879 gemcitabine 100 µM 0.43320712223017 0.35597763464177 no 1218 0.33243215257055 1595 60750 A nucleoside analog which inhibits DNA replication. SGTC_1511 0906-3109 28.5 µM 0.432906122009336 0.356071833383329 no 1219 0.332541486136047 1566 2882180 SGTC_394 menadione 8.33 µM 0.42963335022943 0.357096621167767 no 1220 0.333731186613527 1598 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3201 9113999 49.47 µM 0.425701761628304 0.358329065108188 no 1221 0.335162589123383 1671 16649224 SGTC_716 1683-5115 658 µM 0.425372257472038 0.358432422790169 no 1222 0.335282663284063 1612 723597 SGTC_633 0437-0093 97.7 µM 0.421702722961437 0.359584168586403 no 1223 0.33662100834461 1580 2831118 SGTC_1376 2910-0861 41.3 µM 0.418882992738972 0.360470056909535 no 1224 0.337650823541276 1623 1112859 SGTC_2947 9072639 7.68 µM 0.418506956981384 0.36058825463183 no 1225 0.337788250554022 1517 16488146 SGTC_593 1203-0218 61.7 µM 0.418014626314743 0.360743026975295 no 1226 0.337968211703428 1705 3666956 SGTC_2279 7948423 32.93 µM 0.416930056823775 0.361084059900991 no 1227 0.33836478395706 1767 1247112 SGTC_911 3456-4043 236 µM 0.415995595626214 0.361377981243435 no 1228 0.338706613054749 1682 914281 SGTC_136 0097-0015 404.482 µM 0.415213829685335 0.361623937366043 no 1229 0.338992687820264 1635 4861337 SGTC_1473 k844-0725 134 µM 0.411707398250265 0.362727819163809 no 1230 0.340276950851871 1658 54682906 SGTC_2372 9071633 200 µM 0.408316124950637 0.363796533807785 no 1231 0.341520801216372 1667 21321366 SGTC_328 k915-0120 63.5 µM 0.407889603177815 0.363931021714456 no 1232 0.341677363029219 1699 6624543 SGTC_1319 1306-0155 43.7 µM 0.40700223857445 0.36421087310454 no 1233 0.342003172022781 1643 3122360 SGTC_2431 5490079 200 µM 0.406724583960564 0.364298452927435 no 1234 0.342105141190628 1582 5722345 SGTC_1154 4088-0362 150 µM 0.40295863588799 0.365487033568524 no 1235 0.343489327202505 1586 6618304 SGTC_686 1319-0111 510 µM 0.402274856885827 0.365702981849431 no 1236 0.34374087828932 1727 4562600 SGTC_624 k048-0052 28 µM 0.4015609900256 0.365928477771658 no 1237 0.344003572041964 1617 6835531 SGTC_1201 1889-3372 45.9 µM 0.396336937079897 0.367580054427942 no 1238 0.3459282408399 1631 5392199 SGTC_2635 hydroquinidine 100 µM 0.39370179217786 0.368414084017209 no 1239 0.346900609025147 1633 442912 An experimental heart treatment. SGTC_2274 7947094 46.08 µM 0.392915346350803 0.368663116362403 no 1240 0.347191003271902 1592 2971028 SGTC_2627 acetyl isogambogic acid 100 µM 0.39256370420827 0.368774483611735 no 1241 0.347320875786585 1563 6857789 A caspase activator and apoptosis inducer. SGTC_422 cantharidin 155 µM 0.389820581663679 0.369643625188671 no 1242 0.348334611710558 1562 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_729 4092-0585 94.1 µM 0.388634321396636 0.370019691180446 no 1243 0.34877333698448 1587 2169061 SGTC_1098 clofazimine 15.1 µM 0.388195922767787 0.370158702966378 no 1244 0.348935525107462 1699 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.388111718331654 0.370185405286701 no 1245 0.348966680189457 1527 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1050 3232-1156 69.3 µM 0.383681121767123 0.371591284675026 no 1246 0.350607403170577 1613 700529 SGTC_1063 disulfiram 1.84 µM 0.382671230727957 0.371911975359867 no 1247 0.350981774124597 1653 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3350 9150499 3.57 µM 0.38214722472977 0.372078408393012 no 1248 0.351176082445303 1628 4910996 YPR165W RHO1 SGTC_1370 2001-0092 44.6 µM 0.381550662956951 0.372267915443438 no 1249 0.35139734276846 1803 790957 SGTC_2340 7987427 183.45 µM 0.37963098077086 0.372877941849025 no 1250 0.352109680094601 1689 2239331 SGTC_151 3013-0144 2.285 µM 0.378274253096313 0.373309268003908 no 1251 0.352613434982322 1745 906558 YHR107C CDC12 SGTC_548 1436-0017 110 µM 0.378146068198962 0.373350028320454 no 1252 0.352661043597479 1779 9677137 SGTC_1617 st002906 78 µM 0.376264498506808 0.373948493920852 no 1253 0.353360134707743 1650 5150859 SGTC_1574 spiramycin 23.7 µM 0.373987567636925 0.374673117356548 no 1254 0.354206782870641 1607 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1087 pterostilbene 9.05 µM 0.372781296343806 0.375057187585396 no 1255 0.354655612222316 1771 5281727 Similar to reservatol, lowers cholesterol. SGTC_2801 7907800 81.82 µM 0.370426332184803 0.375807352198786 no 1256 0.355532428391774 1651 6620925 SGTC_364 0083-0097 67.7 µM 0.370094619332966 0.375913055829424 no 1257 0.355655995543066 1683 5207356 SGTC_3325 9138760 55.175 µM 0.370045392124408 0.375928743367333 no 1258 0.355674334581807 1616 43844959 SGTC_1123 mangostin 811.285 nM 0.369856945111952 0.375988798832808 no 1259 0.35574454146787 1640 5281650 An antioxidant. SGTC_572 0960-0087 17.7 µM 0.369659773314157 0.376051637982465 no 1260 0.355818004055296 1592 6796365 SGTC_2508 celastrol 40.54 µM 0.369386835854417 0.376138629263078 no 1261 0.35591970437143 1640 122724 Celastrol is a natural product and antioxidant. SGTC_881 0833-0569 170 µM 0.369249174683396 0.376182507348979 no 1262 0.355971002740269 1601 5418700 SGTC_2095 5432005 200 µM 0.368555256746197 0.376403710928584 no 1263 0.356229625567419 1655 783734 SGTC_2488 5268135 45.7 µM 0.368419499162284 0.376446991781219 no 1264 0.356280230083165 1745 1270356 YLR208W SEC13 SGTC_842 0271-0008 11.1 µM 0.368068640316276 0.376558856225362 no 1265 0.35641102670469 1732 1221709 SGTC_1935 st074532 41.6 µM 0.368014313117699 0.376576178311526 no 1266 0.356431280844314 1832 2829742 SGTC_1503 4585-0012 61.3 µM 0.366226762674467 0.377146272555432 no 1267 0.357097936797876 1743 2922052 SGTC_2657 nystatin 74.44 µM 0.365876253571355 0.377258090068656 no 1268 0.357228708266702 1718 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2200 6600604 21.907 µM 0.364997959548349 0.377538323850758 no 1269 0.357556464688237 1665 2904777 SGTC_2914 7968218 45.32 µM 0.364960787935113 0.37755018547289 no 1270 0.357570338484222 1769 2977111 SGTC_760 0568-0725 82.9 µM 0.364907723812412 0.377567118663462 no 1271 0.357590144268013 1791 3916171 SGTC_1238 0333-0287 48.8 µM 0.364018192641564 0.377851010265525 no 1272 0.357922212134066 1665 7226 SGTC_114 0364-0001 490.298 µM 0.363464475194587 0.378027761106373 no 1273 0.358128972839019 1620 4003655 SGTC_2514 salinomycin 42.74 µM 0.361506828164266 0.378652861486822 no 1274 0.358860300752029 1838 23682228 A polyether potassium ionophore. SGTC_121 0557-0495 61.343 µM 0.360712722753893 0.378906519594973 no 1275 0.359157106393889 1701 3104427 SGTC_1187 1391-0724 117 µM 0.36001852638812 0.379128306868503 no 1276 0.359416639592112 1719 6997986 SGTC_1220 1838-0075 193 µM 0.355278519592014 0.380643741241485 no 1277 0.36119047302663 1729 5529645 SGTC_876 0720-0963 56.8 µM 0.355248952407613 0.380653199985578 no 1278 0.361201547252526 1840 765861 SGTC_2850 9015429 58.44 µM 0.3538175602501 0.381111197332563 no 1279 0.361737806258056 1645 6457570 SGTC_416 estradiol valerate 100 µM 0.353607786711948 0.381178331820309 no 1280 0.361816418992063 1721 13791 A steroid. SGTC_477 mead ethanolamide 10 µM 0.353465522899728 0.381223862992481 no 1281 0.361869735742527 1687 16061185 SGTC_1258 0671-0043 57.1 µM 0.35281701037788 0.381431438601846 no 1282 0.362112815202793 1659 4298767 SGTC_2747 doxorubicin 7.63 µM 0.352816913942533 0.381431469471368 no 1283 0.362112851353422 1783 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3192 9110362 49.47 µM 0.352577234162142 0.381508194710378 no 1284 0.362202703691576 1727 16649480 SGTC_1964 st076914 61 µM 0.351437926871994 0.38187296838376 no 1285 0.362629916584613 1704 24208661 SGTC_2231 micatex 6.853 µM 0.351303993352585 0.381915856970858 no 1286 0.3626801496882 1725 20737 An antifungal of unknown mechanism. SGTC_1424 4048-1941 275 µM 0.350388760007646 0.38220897446094 no 1287 0.363023480312017 1825 X1424 SGTC_535 2293-4129 48.2 µM 0.349686237677077 0.382434013806197 no 1288 0.3632870915703 1815 396118 YIL048W NEO1 SGTC_2069 5228469 200 µM 0.348986820311918 0.382658097985064 no 1289 0.363549602074342 1667 2835210 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.348300357800056 0.382878069804771 no 1290 0.36380731258147 1672 6312947 SGTC_1847 st056231 15 µM 0.345204635287592 0.383870539536104 no 1291 0.364970267131135 1664 5393180 SGTC_2330 7979373 200 µM 0.342361223177997 0.384782791847621 no 1292 0.36603953330735 1590 1863007 SGTC_852 0418-0143 439 µM 0.339130368063623 0.385820122009128 no 1293 0.367255761077804 1829 5369229 SGTC_2969 9091408 28.7 µM 0.337029555625895 0.386495068392221 no 1294 0.368047310008504 1627 4286311 SGTC_3158 9100007 49.47 µM 0.335698225795049 0.386922974343443 no 1295 0.368549221936623 1672 19297233 SGTC_910 3454-3003 490 µM 0.334870015658145 0.387189240773088 no 1296 0.36886157077387 1809 820824 SGTC_2753 fluvastatin 17.09 µM 0.333493629829553 0.3876318609851 no 1297 0.369380848589004 1741 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1221 2958-7315 257 µM 0.333393214894952 0.387664158293922 no 1298 0.36941874211031 1748 4562705 SGTC_3335 9143315 29.6265 µM 0.333067835801012 0.387768818076352 no 1299 0.369541538929967 1711 4899691 SGTC_3117 9124945 49.47 µM 0.332871695476147 0.387831911514239 no 1300 0.369615567964825 1642 17592065 SGTC_3179 9107801 49.47 µM 0.329370413858325 0.388958683060471 no 1301 0.370937863824705 1711 4818259 SGTC_232 clozapine 119 µM 0.327850587204799 0.389448080409372 no 1302 0.371512318105935 1774 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.327509026967102 0.389558089929121 no 1303 0.371641458287019 1844 16725076 SGTC_968 1309-0633 340 µM 0.326134997327543 0.390000725912349 no 1304 0.372161109647967 1855 3761976 SGTC_1454 4239-0054 42.6 µM 0.325686640013512 0.390145192621132 no 1305 0.372330726658949 1842 1340767 SGTC_2623 humulene 100 µM 0.325069719574609 0.390343997416242 no 1306 0.372564152875937 1699 6187145 An anti-inflammatory. SGTC_2715 st079500 56.4 µM 0.324504927147374 0.390526028921565 no 1307 0.372777896297369 1685 28246688 SGTC_953 1188-0045 9.7 µM 0.324485719976625 0.390532219777646 no 1308 0.372785165863025 1788 6144426 SGTC_2292 7671323 168.05 µM 0.323162618285589 0.390958748691993 no 1309 0.373286044775587 1731 937504 SGTC_1485 3909-9022 254 µM 0.320840794170415 0.391707553075439 no 1310 0.374165521525559 1799 714516 SGTC_2953 9074162 66.49 µM 0.317553647376224 0.392768366545254 no 1311 0.375411769706009 1918 16451992 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.31616764281909 0.393215891141474 no 1312 0.37593763312973 1824 5282309 SGTC_1134 3477-0009 42.5 µM 0.314735458711882 0.393678474850175 no 1313 0.376481259643304 1915 3973534 SGTC_689 0833-0039 98 µM 0.314528376119761 0.393745373262193 no 1314 0.376559884080185 1859 5374726 SGTC_1839 st053978 48 µM 0.314416027963236 0.393781668853041 no 1315 0.376602542201502 1796 3788398 SGTC_2442 5158906 48.48 µM 0.314295965142523 0.393820457790446 no 1316 0.376648131213919 1845 1893835 SGTC_2071 5230951 39.92 µM 0.313784060595451 0.393985851640847 no 1317 0.376842525610661 1841 1799272 SGTC_972 1319-0219 195 µM 0.313689889167959 0.394016280050905 no 1318 0.376878290363106 1721 23903702 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.313277014197283 0.39414969469859 no 1319 0.377035105922817 1875 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1616 st002734 56.1 µM 0.31304230216496 0.394225544077056 no 1320 0.377124261807181 1790 4026101 SGTC_1737 st035557 69.7 µM 0.31285199813455 0.394287045541215 no 1321 0.377196554023073 1695 5716916 SGTC_252 miconazole 1.30953 nM 0.312616208091198 0.394363250593609 no 1322 0.377286131321071 1815 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_596 1155-0152 116 µM 0.312459091972762 0.394414031242404 no 1323 0.37734582384077 1734 280313 SGTC_2065 5221596 34.26 µM 0.312453302615562 0.394415902423441 no 1324 0.377348023424867 1787 788581 SGTC_2470 5664817 21.68 µM 0.311286671421554 0.394793019533507 no 1325 0.377791349483986 1772 2859561 SGTC_2942 9052777 62.25 µM 0.307210162232713 0.396111535652038 no 1326 0.379341705481173 1773 6469503 SGTC_2555 cholic acid 100 µM 0.306630336589007 0.396299172843057 no 1327 0.37956238000617 1807 6708657 Influences liver metabolism. SGTC_3186 9110464 49.47 µM 0.305766239666856 0.396578847538047 no 1328 0.379891317480049 1846 17018021 SGTC_61 0978-8327 98.565 µM 0.305400029294388 0.396697391711572 no 1329 0.380030749740077 1847 6150059 YHR072W ERG7 SGTC_1178 0988-0033 191 µM 0.304319261753265 0.397047297332115 no 1330 0.380442335939723 1802 5392207 SGTC_2597 laccaic acid a 100 µM 0.304074028989035 0.39712670460533 no 1331 0.380535746227119 1772 5491415 A textile dye. SGTC_106 0092-0003 11.579 µM 0.304036263914121 0.397138933454854 no 1332 0.380550131736863 1892 1072148 SGTC_2418 pentamidine 31.67 µM 0.303461067189059 0.397325202541356 no 1333 0.380769256648765 1727 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2189 6047310 154.431 µM 0.301209178344935 0.398054668902183 no 1334 0.381627495670577 1783 711535 SGTC_2481 5478948 45.16 µM 0.299678777094311 0.398550623564923 no 1335 0.382211094214384 1767 77792 SGTC_1461 k072-0203 53.8 µM 0.299487961921066 0.398612472237363 no 1336 0.382283877886648 1774 5418714 SGTC_1905 st060207 84.5 µM 0.29938802338679 0.398644866199916 no 1337 0.382321999646753 1776 1948547 SGTC_1412 3909-8563 178 µM 0.298931352913292 0.398792899729182 no 1338 0.382496212050445 1903 23767530 SGTC_3121 9125696 49.47 µM 0.298921954267089 0.398795946531446 no 1339 0.382499797731941 1900 1235365 SGTC_3290 9121031 71.43 µM 0.29831322349728 0.398993294705262 no 1340 0.38273205630842 1744 17014854 SGTC_3214 9129694 49.47 µM 0.297521512316508 0.399250003049563 no 1341 0.383034193357249 1891 17158655 SGTC_3235 9132602 49.47 µM 0.297048090744242 0.399403528424081 no 1342 0.383214897043369 1810 4912240 SGTC_974 1326-0144 138 µM 0.294818909201959 0.40012663604363 no 1343 0.384066110336471 1758 5411856 SGTC_278 4092-0821 23.9 µM 0.293475903721149 0.400562449120532 no 1344 0.384579207550021 1855 877900 SGTC_3252 9135871 49.47 µM 0.293104220752964 0.40068308430055 no 1345 0.384721245345294 1850 17682838 SGTC_2023 5144124 124 µM 0.292760374710239 0.400794693032204 no 1346 0.384852659103291 1772 2830192 SGTC_1945 st075991 56.6 µM 0.292133770355096 0.400998102894791 no 1347 0.385092173645884 1735 1084980 SGTC_2108 5365811 200 µM 0.291651381087539 0.401154715586236 no 1348 0.385276592991579 1861 780283 SGTC_1171 0368-0077 21.4 µM 0.291279738236559 0.401275384136002 no 1349 0.385418691237405 1778 3239779 SGTC_1751 st044839 27.194 µM 0.291121253631486 0.401326845295784 no 1350 0.385479292762609 1874 5291326 SGTC_2892 9047358 58.44 µM 0.290778631593071 0.401438103133201 no 1351 0.385610314525526 1780 6466771 SGTC_2650 prasterone 100 µM 0.289266245931454 0.401929307479271 no 1352 0.386188820262425 1843 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_622 1348-1566 26.3 µM 0.289130965215289 0.401973252560989 no 1353 0.386240579118423 1880 7340407 SGTC_2265 7929201 200 µM 0.287926766482727 0.402364483426943 no 1354 0.386701398712666 1706 1265108 SGTC_2875 9039966 71.43 µM 0.286247698864922 0.402910157158839 no 1355 0.387344206499909 1902 6463691 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.286015131450307 0.402985753287604 no 1356 0.387433266117825 1828 165521 SGTC_994 3910-0338 138 µM 0.285997730921188 0.402991409482226 no 1357 0.387439929733573 1879 3479481 SGTC_3139 9095020 49.47 µM 0.285741300690371 0.403074766731353 no 1358 0.387538134759762 1804 25236292 SGTC_2576 guaiol 23.12 µM 0.285115931752631 0.403278072592478 no 1359 0.387777662319046 1958 227829 SGTC_1944 st076371 56.9 µM 0.283520761931386 0.403796776550424 no 1360 0.388388834296698 1757 24208455 SGTC_386 1509-0011 3.07 µM 0.283326972935585 0.403859802778926 no 1361 0.38846310130635 1790 3107280 SGTC_2309 7664088 163.95 µM 0.282575527018745 0.404104220031417 no 1362 0.388751121322971 1969 704922 SGTC_362 0310-0100 9.03 µM 0.279541517051799 0.405091449826859 no 1363 0.38991464067142 1796 790235 SGTC_3233 9132340 49.47 µM 0.278147286574555 0.405545318428546 no 1364 0.390449648941421 1780 17682950 SGTC_2678 equilin 100 µM 0.277675997263695 0.405698767601878 no 1365 0.390630543836323 1934 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1610 st001799 48.1 µM 0.277406124488098 0.405786643200554 no 1366 0.390734139719381 1743 621897 SGTC_806 3966-4455 5.86 µM 0.275319349800032 0.406466295848648 no 1367 0.391535449856464 1756 714982 SGTC_1132 3456-3614 2.5 µM 0.27513768796728 0.406525475615518 no 1368 0.391605228848701 1984 3125502 SGTC_2760 etidronate 98.04 µM 0.274369589237834 0.406775721840691 no 1369 0.391900305436399 1796 3305 A chelator and antioxidant. SGTC_2311 7694451 200 µM 0.272884918547815 0.407259534721125 no 1370 0.392470839978123 1857 2163142 SGTC_1730 st033808 45.1 µM 0.27269856358527 0.407320272631781 no 1371 0.392542469481989 1810 1045166 SGTC_3041 9091929 49.47 µM 0.272386287820741 0.407422056389434 no 1372 0.392662507490982 1877 25236887 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.271957537938059 0.407561814124486 no 1373 0.392827334486114 1846 88881 An O-methylated flavonoid and antioxidant. SGTC_1754 st042065 16.137 µM 0.271727414722555 0.407636831241981 no 1374 0.392915810119386 1864 1126236 YIL048W NEO1 SGTC_36 0335-0881 14.2 µM 0.271076755808982 0.407848955739716 no 1375 0.393165999328267 1836 23828853 SGTC_1740 st038286 13.222 µM 0.270391712928959 0.408072319117496 no 1376 0.393429457435819 1860 716786 SGTC_757 1066-0008 322 µM 0.269566300795688 0.408341490626535 no 1377 0.393746964454917 1900 6842497 SGTC_3304 9125678 46.087 µM 0.269367273811575 0.40840640091504 no 1378 0.393823533715981 1796 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3346 9158254 43.5805 µM 0.268587059671126 0.408660882716026 no 1379 0.394123735693404 1829 17639500 SGTC_1205 4161-2785 76 µM 0.268401865581154 0.408721292979348 no 1380 0.394195001827527 1728 3498106 SGTC_2332 7982454 138.89 µM 0.266994176500133 0.409180551580469 no 1381 0.394736822434986 1866 2981748 SGTC_2234 tolnaftate 200 µM 0.266956303694082 0.409192909309739 no 1382 0.394751402525191 1915 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3155 9099265 49.47 µM 0.266373186834158 0.409383189149072 no 1383 0.39497590663703 1882 25236499 SGTC_1819 st053448 58.6 µM 0.265385604055873 0.409705501004963 no 1384 0.39535621249636 1866 2857616 SGTC_180 1486-1293 102.781 µM 0.261598393215391 0.410942075721777 no 1385 0.396815541460065 2005 4140536 SGTC_1818 st052136 56.3 µM 0.261340253517159 0.411026394142252 no 1386 0.396915063513789 1822 674169 SGTC_1790 st045711 43.5 µM 0.258946132549385 0.411808602122509 no 1387 0.397838401563136 1967 585119 SGTC_3025 9087895 49.47 µM 0.258660240144176 0.411902032474366 no 1388 0.397948699746201 1961 17173641 SGTC_179 1273-0063 6.77 µM 0.258294450300922 0.412021580790918 no 1389 0.3980898345039 1791 3108139 SGTC_1784 st039334 36.3 µM 0.257934060256116 0.412139372317836 no 1390 0.398228898868424 1962 3496984 SGTC_1706 st031321 9.9705 µM 0.257372014209675 0.412323089807704 no 1391 0.398445802397976 1948 6103185 SGTC_1385 3091-4834 14.1 µM 0.257273112911533 0.412355419927817 no 1392 0.398483973409996 1905 4072814 SGTC_2134 5324836 1.464 µM 0.257202293927567 0.412378570507645 no 1393 0.398511306633719 1866 699272 SGTC_1966 st070145 16.1 µM 0.255839511358757 0.412824120605632 no 1394 0.399037381641411 1818 3748532 SGTC_334 1502-1024 68.5 µM 0.254434478656531 0.413283601630763 no 1395 0.39957995852913 1886 3296216 SGTC_129 0088-0017 176.636 µM 0.253235670702803 0.413675735925252 no 1396 0.400043051696084 1975 182446 SGTC_1663 st014140 55.4 µM 0.251614246986128 0.414206246240887 no 1397 0.400669622676102 1921 4207120 SGTC_210 3551-0445 56.827 µM 0.25088643080979 0.414444429903319 no 1398 0.400950957805775 1916 2865180 YOR207C RET1 SGTC_2160 5660466 132.927 µM 0.250795951221093 0.41447404227274 no 1399 0.400985936008946 1983 2859134 SGTC_900 1112-0045 141 µM 0.250225750551307 0.414660670047092 no 1400 0.401206386240466 1962 56211 YIL048W NEO1 SGTC_755 1995-0008 37.3 µM 0.250034220353202 0.414723362573206 no 1401 0.40128044245415 1974 689533 SGTC_1034 k072-0165 12.7 µM 0.249595215845111 0.414867067696409 no 1402 0.401450199359408 1989 5835461 SGTC_2433 5607874 27.82 µM 0.24903558836685 0.415050274439968 no 1403 0.401666626447395 1815 2252428 SGTC_303 1348-1668 34.2 µM 0.248869468074388 0.415104661241987 no 1404 0.401730876655603 1901 5380509 SGTC_1302 1159-0335 255 µM 0.24727120733554 0.415628005339154 no 1405 0.402349170115801 1835 649284 SGTC_358 0075-0058 9.45 µM 0.247149952811639 0.415667715769477 no 1406 0.402396087898725 2087 1069125 SGTC_1338 1486-1223 76 µM 0.246681689241766 0.41582107852394 no 1407 0.402577289289286 1939 3444526 SGTC_1356 1502-0781 85.8 µM 0.240250635218632 0.417928624583385 no 1408 0.405067980850002 1864 567702 SGTC_1755 st041960 45.185 µM 0.23743410929484 0.418852385854262 no 1409 0.406160015381739 1898 2257073 SGTC_108 0509-0257 621.132 µM 0.236174272308038 0.419265731081951 no 1410 0.406648721296866 1973 536624 SGTC_2037 5169046 200 µM 0.236071237136387 0.419299540274086 no 1411 0.406688696322141 1918 5718022 SGTC_2826 7992541 19.48 µM 0.236043682471397 0.419308581957169 no 1412 0.406699386995942 1966 2985066 SGTC_288 1315-0019 35.1 µM 0.235078096157757 0.419625452656949 no 1413 0.407074059551579 1895 6811474 SGTC_2447 5741742 33.78 µM 0.233354030783383 0.420191358396392 no 1414 0.407743252972779 1929 1776504 SGTC_228 caffeine 993.056 µM 0.232752715969833 0.420388772331627 no 1415 0.407976715861284 1988 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1049 3226-0134 66 µM 0.232270851625926 0.420546984681838 no 1416 0.408163825214614 1961 5702385 SGTC_307 1501-1223 22.3 µM 0.231730429445819 0.420724438818471 no 1417 0.408373697662632 1913 2830329 SGTC_289 k017-0060 526 µM 0.230952463933106 0.420979921451393 no 1418 0.408675865980337 1910 5512909 SGTC_1152 3909-8331 15.9 µM 0.230482474423778 0.421134281389297 no 1419 0.408858440160424 1881 16001939 SGTC_664 1222-0054 14.9 µM 0.229760355229588 0.421371472583676 no 1420 0.409138996266777 1891 6813991 SGTC_60 0986-0278 202 µM 0.228062994187189 0.42192910923496 no 1421 0.409798634182257 1727 3110598 SGTC_1999 st074831 12.5 µM 0.227052807846143 0.422261061709425 no 1422 0.410191339780094 1886 17112523 SGTC_2375 9072683 200 µM 0.224557826720542 0.423081161627671 no 1423 0.411161638170588 2051 16798029 SGTC_3062 9077494 49.47 µM 0.223550261128365 0.423412442996946 no 1424 0.411553634985651 1973 16459633 SGTC_737 1950-0117 57.9 µM 0.221263031716164 0.424164670584387 no 1425 0.412443816509954 2027 5393513 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.219834852500196 0.424634512732027 no 1426 0.412999887576946 1912 5379071 SGTC_793 0488-0545 106 µM 0.216221126762615 0.425823832472547 no 1427 0.414407693130194 1875 292548 SGTC_1195 1502-0147 41.1 µM 0.21587259115774 0.425938575516401 no 1428 0.41454353122951 1896 817940 SGTC_3099 9120367 49.47 µM 0.21433140228515 0.426446032589635 no 1429 0.415144315747225 1935 24824940 SGTC_460 trequinsin 123 µM 0.213765526354465 0.426632385430533 no 1430 0.415364954758301 2028 5537 A vasodilator. SGTC_3048 9093155 49.47 µM 0.213308880135094 0.426782778960918 no 1431 0.415543023798961 2049 25236002 SGTC_1596 piperlongumine 63 µM 0.212141105780056 0.427167426391225 no 1432 0.415998475832817 2049 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3051 9093778 49.47 µM 0.212115878570808 0.427175736622667 no 1433 0.416008316124589 2039 17217378 SGTC_795 0685-0265 78 µM 0.211859309020336 0.427260256421076 no 1434 0.416108398327159 1992 302754 SGTC_2321 7390090 138.78 µM 0.211670334946004 0.427322510880166 no 1435 0.416182116483847 1863 649046 SGTC_2266 7929956 200 µM 0.209458039915262 0.428051449988494 no 1436 0.41704534406402 2003 2967153 SGTC_3347 9188721 44.724 µM 0.20611093827989 0.42915476777591 no 1437 0.41835212735059 1985 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_25 0118-0223 35.662 µM 0.205431429164392 0.429378824836643 no 1438 0.418617533477408 2024 5333628 SGTC_1448 4255-0083 152 µM 0.204732159294124 0.429609421438845 no 1439 0.418890696542347 2025 5399660 SGTC_2441 5730946 39.09 µM 0.203342624191907 0.43006771641415 no 1440 0.419433621044798 2003 1774275 SGTC_2996 9066192 71.4286 µM 0.20091092973777 0.430869961662986 no 1441 0.420384110637952 1879 6472854 SGTC_322 k048-0136 19.3 µM 0.199726686559049 0.431260761257972 no 1442 0.420847170704967 1978 6823282 SGTC_1747 st037496 66.6 µM 0.199226076928183 0.431425982420652 no 1443 0.421042950916597 1952 723305 SGTC_3102 9121669 49.47 µM 0.198034143847024 0.431819416162153 no 1444 0.421509174893431 1953 41905072 SGTC_1255 0566-0045 221 µM 0.197054000573846 0.432142992935954 no 1445 0.42189263989505 1978 2788469 SGTC_2424 5537928 59.2 µM 0.196120621759925 0.432451173581131 no 1446 0.422257877926486 1917 5382802 SGTC_628 1636-0253 16 µM 0.195260786386479 0.432735108214397 no 1447 0.422594397042568 2058 4456143 SGTC_1479 0549-0158 134 µM 0.19440282967132 0.433018457098665 no 1448 0.422930237215254 1952 5440202 SGTC_1016 4226-1401 38 µM 0.194197379168917 0.433086314321873 no 1449 0.423010667464555 2074 2901613 SGTC_2915 7971052 15.16 µM 0.193460948879175 0.433329562411333 no 1450 0.423298993282598 2055 5741558 SGTC_1200 1643-0193 18.4 µM 0.19311789104633 0.433442885448939 no 1451 0.423433320682652 2075 5403974 SGTC_2927 9011802 47.9 µM 0.192974001218205 0.433490418517273 no 1452 0.423489664697535 1878 43912568 SGTC_961 1252-1571 372 µM 0.192431563850221 0.433669617815349 no 1453 0.423702085006591 2070 6813498 SGTC_1883 5-benzylidenerhodanine 20 µM 0.191540324347064 0.433964076776765 no 1454 0.424051145530305 2076 1273210 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.191124895764998 0.434101343850417 no 1455 0.424213871576919 2076 688662 SGTC_1126 isoteolin 1.0172 µM 0.189875594620209 0.434514189244215 no 1456 0.4247033086118 1912 133323 SGTC_1207 2099-0101 141 µM 0.189059519552354 0.434783908878964 no 1457 0.42502308399061 2079 5837381 SGTC_2517 totarol 10 µM 0.188564024996628 0.434947688791219 no 1458 0.425217265411351 1907 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_543 3844-1095 191 µM 0.188130189008748 0.435091097353462 no 1459 0.425387298098759 2034 4230703 SGTC_3207 9114163 49.47 µM 0.187833940092377 0.435189030123661 no 1460 0.425503414467794 2097 849233 SGTC_1651 st011928 86.1 µM 0.186736439977174 0.435551871878531 no 1461 0.425933641820887 2018 720198 SGTC_3159 9100096 49.47 µM 0.185822280348119 0.435854141332251 no 1462 0.426292065819126 2037 25236875 SGTC_2288 7946289 167.31 µM 0.184269021014905 0.436367816740015 no 1463 0.426901207704236 2062 1246052 SGTC_3354 9151612 71.43 µM 0.184240516624738 0.436377244377654 no 1464 0.426912387907775 2070 27261949 SGTC_3254 9136651 49.47 µM 0.182389596999922 0.436989500875975 no 1465 0.427638494636204 1997 16454030 SGTC_3163 9099914 49.47 µM 0.181639767963066 0.437237576139468 no 1466 0.42793271881848 2110 16268368 SGTC_1033 k072-0102 21.3 µM 0.180774098203698 0.437524007114794 no 1467 0.428272447381909 2097 5965931 SGTC_2170 morpholine 200 µM 0.177872073907899 0.438484460799442 no 1468 0.429411721440765 2048 121171 Reacts with secondary amines. SGTC_2851 9015922 71.43 µM 0.177738293050163 0.438528745680915 no 1469 0.429464255263023 2045 2996893 SGTC_920 mycophenolic acid 780.421 nM 0.177688024122863 0.438545386178985 no 1470 0.429483995472031 1951 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2044 5102272 200 µM 0.176254518910736 0.439019964309107 no 1471 0.430046995619259 2012 592666 SGTC_2019 4016004 108 µM 0.175233295588673 0.439358105368962 no 1472 0.430448161491082 1938 45595336 SGTC_1101 ebselen 5.29 µM 0.174444642173661 0.439619269636479 no 1473 0.430758016372146 2118 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.174278947804538 0.439674143026182 no 1474 0.430823121635055 1990 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1436 4092-1007 8.32 µM 0.173885069194752 0.439804589372015 no 1475 0.430977893462683 2027 2881121 SGTC_2300 7976697 71.57 µM 0.168610018838505 0.441552226651957 no 1476 0.433051699752715 1962 2236109 SGTC_262 fenpropimorph 62.5 µM 0.16830209642898 0.441654277609604 no 1477 0.433172812338666 2080 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2107 5363541 170.161 µM 0.167766563059682 0.441831772105513 no 1478 0.43338346421367 2112 244052 SGTC_2026 5148700 152 µM 0.166305710295497 0.442316009110632 no 1479 0.433958186230051 2000 79838 SGTC_948 3448-0295 75.3 µM 0.16534746944207 0.442633689407073 no 1480 0.434335248882222 2039 678569 SGTC_381 3461-2219 42.7 µM 0.164026657312997 0.443071631379743 no 1481 0.434855079257694 2090 2883159 SGTC_1682 st012968 530 nM 0.163093024484177 0.443381238217703 no 1482 0.435222595959501 1934 24207270 SGTC_392 N-ethylmaleimide 8.33 µM 0.162940488219536 0.443431824851908 no 1483 0.43528264590273 1984 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2664 lyso-paf C-16 73.48 µM 0.160728036139907 0.444165658564354 no 1484 0.436153803432832 2086 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_468 gf-109203x 121 µM 0.159082239275349 0.444711666454034 no 1485 0.436802040511992 2131 2396 A protein kinase C inhibitor. SGTC_951 1171-0579 82.7 µM 0.158984807755559 0.444743993535488 no 1486 0.43684042162177 2087 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_851 0394-0702 453 µM 0.158654788280792 0.444853494366475 no 1487 0.436970430308005 2143 762646 SGTC_2317 5986382 200 µM 0.158076325169006 0.445045439222315 no 1488 0.437198327908572 2080 877883 SGTC_1724 st037281 8.293 µM 0.157323399919609 0.445295293165041 no 1489 0.437494989709608 2015 574124 YDL195W SEC31 SGTC_1062 mesoridazine 14.2 µM 0.155545895078993 0.445885234026601 no 1490 0.438195487578739 2116 4078 A neuroleptic. SGTC_1488 4013-0813 75.9 µM 0.154210445189087 0.446328538985222 no 1491 0.43872190331871 2017 2910057 SGTC_1637 st007924 17.4 µM 0.152826743202531 0.446787932076976 no 1492 0.439267453719566 2083 683336 SGTC_2661 dactinomycin 12.96 µM 0.152683349941477 0.446835543151921 no 1493 0.439323995811278 2115 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1608 st001473 40.5 µM 0.152607350536911 0.446860777656516 no 1494 0.43935396400682 1960 7292267 SGTC_2679 rapamycin 1 nM 0.15012502089304 0.447685117057907 no 1495 0.440332989934082 2060 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2120 5538279 151.968 µM 0.149361736436233 0.447938636424457 no 1496 0.440634101449359 2053 2058197 SGTC_2313 7726885 200 µM 0.14858652713994 0.448196138307188 no 1497 0.440939952386264 2038 726423 SGTC_3142 9086498 49.47 µM 0.148349136971348 0.448274996757455 no 1498 0.441033619315548 2160 25236367 SGTC_890 0929-0006 47.2 µM 0.145848003337641 0.449105969960366 no 1499 0.442020689927301 1979 1378169 SGTC_1382 3002-2117 298 µM 0.144558209812807 0.449534576681106 no 1500 0.442529847149911 2146 1497314 SGTC_2939 9044578 71.43 µM 0.144537514855971 0.449541454230274 no 1501 0.442538017440401 2076 2653634 SGTC_629 3448-6466 76.7 µM 0.14384731167342 0.44977083792951 no 1502 0.442810521018062 2102 573744 SGTC_938 3126-1755 342 µM 0.143407953622451 0.449916863933406 no 1503 0.442984000910161 2166 1777771 SGTC_1148 3909-7663 27.7 µM 0.142857620555786 0.450099783401648 no 1504 0.443201314544099 2154 4084526 SGTC_43 0570-0105 72.5 µM 0.141498066384305 0.450551716798955 no 1505 0.443738243738411 2090 1114046 YDL195W SEC31 SGTC_2870 9038528 12.99 µM 0.140638623476939 0.450837439857782 no 1506 0.444077717172854 2070 6463316 SGTC_2157 5649910 96.377 µM 0.140630974509537 0.450839982882849 no 1507 0.444080738641598 2016 2858091 SGTC_3282 9108498 15.4605 µM 0.138541138502673 0.451534858491381 no 1508 0.444906379622359 2034 16459645 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.13744027841344 0.451900957037702 no 1509 0.445341397771341 2144 2346 DNA damaging agent; causes G2/M arrest. SGTC_2895 9054447 58.44 µM 0.136901283192801 0.452080218518257 no 1510 0.44555441227318 2050 2697450 SGTC_658 3253-0951 102 µM 0.136673466767529 0.452155989680037 no 1511 0.44564445157159 2088 1184878 SGTC_1951 sophoraflavanone G 9.2 µM 0.13666717046796 0.452158083837968 no 1512 0.445646940081669 1961 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1015 4130-4525 82 µM 0.136462929735113 0.452226015309294 no 1513 0.445727664072862 1970 1363237 SGTC_2703 st077852 53.4 µM 0.13411926122943 0.453005630583772 no 1514 0.446654134494211 2079 6281836 SGTC_1137 ixabepilone 100 µM 0.133436706930179 0.453232714707969 no 1515 0.446924008513924 2115 154225 A novel microtubule stabilizer. SGTC_1046 2001-0062 216 µM 0.133336099460662 0.453266187858868 no 1516 0.446963789617089 2051 739778 SGTC_2814 7977482 42.97 µM 0.133236750149051 0.453299242733398 no 1517 0.447003073756925 2134 6456762 SGTC_1294 1000-1494 117 µM 0.132966832644835 0.453389049611108 no 1518 0.447109805625978 2036 712797 YDL207W GLE1 SGTC_2322 7413319 38.22 µM 0.132140550162856 0.453663984889807 no 1519 0.447436561360071 2074 1840400 SGTC_877 0771-0151 33.1 µM 0.131494474824531 0.453878973947665 no 1520 0.447692078538307 2085 6166523 SGTC_1271 0832-2808 169 µM 0.13103266812719 0.45403265376581 no 1521 0.447874732381618 2169 3663794 SGTC_873 0591-4978 488 µM 0.131012871395688 0.454039241866925 no 1522 0.447882562634704 2180 3305145 SGTC_2100 5377183 190 µM 0.130355179500013 0.454258120564535 no 1523 0.448142712760123 2123 2844202 SGTC_1272 0839-0021 27 µM 0.129975751095235 0.454384399988418 no 1524 0.448292805873754 2115 5027250 SGTC_1609 st001574 46.4 µM 0.128055843429217 0.455023444281728 no 1525 0.449052390053051 2137 3960012 SGTC_1093 fluphenazine 7.97 µM 0.127176888039847 0.455316044914855 no 1526 0.44940019875151 2100 6602611 An atypical antipsychotic. SGTC_1522 st012842 45.6 µM 0.12673558733114 0.455462961256143 no 1527 0.449574839157663 2028 3491067 YOR116C RPO31 SGTC_2150 5556613 200 µM 0.126142701620691 0.455660352349131 no 1528 0.449809483204861 2103 743190 SGTC_1713 st033146 12.748 µM 0.124147905757585 0.456324565386378 no 1529 0.450599084106415 2176 674619 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.123966280122948 0.456385047898104 no 1530 0.450670986819661 2086 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3003 9075612 71.4286 µM 0.122256065656455 0.45695460974902 no 1531 0.451348112722259 2114 6501993 SGTC_1992 st073643 23.3 µM 0.122014316348641 0.457035127972181 no 1532 0.451443840090112 2192 3161292 SGTC_2250 alverine citrate 130 µM 0.121902708165843 0.457072301342275 no 1533 0.451488035409919 2074 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1868 st057644 42.7 µM 0.121702653394069 0.457138934583494 no 1534 0.451567255878456 2184 688665 SGTC_2843 9000894 45.46 µM 0.121346229346923 0.457257653504327 no 1535 0.451708402403051 2211 2242070 SGTC_2605 digitonin 300 nM 0.12102991207556 0.457363016720405 no 1536 0.451833671465256 2209 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.119700689676655 0.457805804686912 no 1537 0.452360127002945 2135 5357218 A potent inhibitor of glutathione S-transferases. SGTC_646 4092-0839 27.3 µM 0.119574456693037 0.457847857903304 no 1538 0.452410127561053 2151 877796 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.118917048762302 0.458066874191851 no 1539 0.452670537323341 2142 5106787 A p450 inhibitor. SGTC_1017 4239-0030 168 µM 0.118426818177851 0.458230203426065 no 1540 0.452864738730927 1998 1149593 SGTC_868 0527-0199 213 µM 0.118420293009455 0.458232377452203 no 1541 0.452867323706758 2075 2849450 SGTC_510 ag-490 170 µM 0.118204241615761 0.45830436118506 no 1542 0.452952914599281 2224 5328779 SGTC_2924 9010168 62.78 µM 0.117140011151204 0.45865896007213 no 1543 0.453374551831089 2096 2993929 SGTC_1727 st034309 9.9045 µM 0.114975199100035 0.459380371178356 no 1544 0.45423238995471 2207 870305 SGTC_158 k038-0087 26.446 µM 0.113459441032932 0.459885568560223 no 1545 0.454833158378024 2087 X158 SGTC_590 k048-0076 22.4 µM 0.113399378124735 0.459905588677575 no 1546 0.454856966358392 2218 6832814 SGTC_2904 7225135 42.03 µM 0.113372739837196 0.459914467761409 no 1547 0.454867525403298 2212 4446116 SGTC_772 k072-0172 35.3 µM 0.110728102828851 0.460796077940741 no 1548 0.455915980086204 2005 5861980 SGTC_3348 9149464 3.537 µM 0.110322604518918 0.460931271084244 no 1549 0.456076765435108 2230 1951442 SGTC_617 3770-0098 35 µM 0.109131215327184 0.461328506327124 no 1550 0.456549208245894 2109 5962639 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.108612489760091 0.461501472869896 no 1551 0.456754926983914 2120 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_39 0986-0283 58.349 µM 0.107314351624111 0.461934362625664 no 1552 0.457269799671262 2207 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2607 solasodine 47.35 µM 0.107029155859 0.462029472836548 no 1553 0.457382924785361 2107 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1096 rimcazole 32.2 µM 0.106626505758628 0.462163756702545 no 1554 0.457542644950308 2087 18528119 A dopamine reuptake inhibitor. SGTC_438 sphingosine 6.67 µM 0.106624305624757 0.462164490459366 no 1555 0.457543517701461 2088 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1668 st014914 51.6 µM 0.105485536622545 0.462544293447458 no 1556 0.457995273030375 2189 2839556 SGTC_223 busulfan 5 mM 0.104236933771457 0.462960767531977 no 1557 0.458490662345815 2193 2478 A DNA alkylator. SGTC_703 3875-0075 71.8 µM 0.0995133002546587 0.464536708894465 no 1558 0.460365364120629 2156 2850814 SGTC_3199 9111318 49.47 µM 0.0977559471847028 0.465123156282128 no 1559 0.461063044412545 2193 8548020 SGTC_244 nsc-207895 1.295 µM 0.0976091154284404 0.465172159046 no 1560 0.461121343004628 2209 42640 SGTC_1135 dihydrocapsaicin 536.708 nM 0.097547596676027 0.465192690108446 no 1561 0.461145768872868 2189 107982 A Capsaicinoid. SGTC_2001 4023502 57.655 µM 0.0965893154600753 0.465512515601911 no 1562 0.461526270923288 2165 108941 YCR052W RSC6 SGTC_2806 7952793 58.44 µM 0.0954443733444893 0.465894668194348 no 1563 0.46198093604699 2178 2972490 SGTC_1285 0929-0069 65.5 µM 0.0950772825737495 0.466017200443382 no 1564 0.462126721100074 2142 1206237 SGTC_3065 9113888 49.47 µM 0.0947083777259675 0.466140341463626 no 1565 0.462273231714942 2206 16648368 SGTC_2240 6690706 185.951 µM 0.0946670169964896 0.4661541479427 no 1566 0.462289658454271 2147 805876 SGTC_1340 1486-1359 257 µM 0.094269298603292 0.466286910991871 no 1567 0.462447618723988 2138 4309068 SGTC_231 b-estradiol 524 µM 0.0940449161065102 0.466361814148714 no 1568 0.462536738463636 2167 450 A steroid. SGTC_1428 4049-0204 61.7 µM 0.0938708163136311 0.466419932801025 no 1569 0.462605888327011 2236 X1428 SGTC_571 k831-0106 44.2 µM 0.0919686132574674 0.467054979816944 no 1570 0.46336148843408 2256 4783639 SGTC_412 gemfibrozil 100 µM 0.0902327776858773 0.467634558582621 no 1571 0.464051118865759 2247 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_194 1486-1323 56.904 µM 0.0882448564252667 0.468298390548169 no 1572 0.464841033039958 2123 5178754 SGTC_2787 5284540 71.43 µM 0.0867094551871956 0.468811171705608 no 1573 0.465451230287589 2155 736958 SGTC_738 1315-0003 72.4 µM 0.0851383282932383 0.469335937792104 no 1574 0.466075709670233 2252 6251474 SGTC_1822 st052468 42 µM 0.0842657824020902 0.469627396575017 no 1575 0.466422558649239 2216 2873678 SGTC_577 r071-0003 38.6 µM 0.0803216858039093 0.470945054236716 no 1576 0.467990705578723 2259 4568517 YMR134W ERG29 SGTC_3326 9140064 16.379 µM 0.080298154542328 0.470952916612407 no 1577 0.468000062969067 2247 1868434 SGTC_2505 galangin 7.89 µM 0.0788618381555125 0.471432846714067 no 1578 0.468571258703857 2173 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_986 1493-0483 84 µM 0.0783370223910477 0.471608218799925 no 1579 0.468779984163108 2270 40079 SGTC_2359 9039622 200 µM 0.0756005270418849 0.472522732680077 no 1580 0.469868458573685 2219 6463596 SGTC_2763 lisinopril 49.32 µM 0.0745074119741978 0.472888083363804 no 1581 0.470303321829702 2294 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_835 0312-0010 67.2 µM 0.0738507690677224 0.473107563408605 no 1582 0.470564564704543 2260 1626196 SGTC_2473 5854593 8.94 µM 0.0730865198892401 0.473363020659901 no 1583 0.470868634269574 2200 2872951 SGTC_2025 5147754 141 µM 0.0730055738460979 0.473390078255783 no 1584 0.470900841030679 2262 315777 YLR208W SEC13 SGTC_540 1187-0821 17.3 µM 0.072992723381925 0.473394373753961 no 1585 0.470905953982851 2144 847520 SGTC_1151 3909-8316 15.3 µM 0.0724067763109547 0.473590240352586 no 1586 0.471139096117766 2193 800431 SGTC_899 1083-0020 478 µM 0.0717690912580712 0.47380340884311 no 1587 0.471392835485465 2262 767123 SGTC_2867 9039098 71.43 µM 0.0713332845928483 0.473949096753729 no 1588 0.471566252709266 2296 6463460 SGTC_2365 9042475 200 µM 0.07097739570785 0.474068071149639 no 1589 0.471707872860438 2193 6464479 SGTC_339 3091-4833 71.4 µM 0.0680310990256495 0.475053112117241 no 1590 0.472880439091051 2219 3240077 SGTC_3333 9141820 12.094 µM 0.0671680470376839 0.475341687077135 no 1591 0.473223961214314 2168 1939433 SGTC_2350 9023895 38.85 µM 0.0655928438642041 0.475868414191541 no 1592 0.473850993307151 2241 2997209 SGTC_19 0279-0214 38.434 µM 0.0647960292000556 0.476134874599813 no 1593 0.474168201523789 2286 3566274 YBR002C RER2 SGTC_2764 methyldopa 94.69 µM 0.0621349171334722 0.477024845792615 no 1594 0.475227695428104 2293 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1417 3966-0327 90.4 µM 0.0598668021514757 0.477783475323848 no 1595 0.476130860248303 2249 651118 SGTC_351 caspofungin 25 nM 0.0590899686213204 0.478043325974306 no 1596 0.47644022428108 2232 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1988 st071872 53.4 µM 0.0590379581450933 0.478060723802156 no 1597 0.476460937298324 2315 16414116 SGTC_3013 9080133 71.4286 µM 0.0579635466031489 0.478420130450789 no 1598 0.476888832640343 2270 17050193 SGTC_1870 st057514 26.5 µM 0.0578753428027788 0.478449636718011 no 1599 0.476923961892761 2291 5393161 SGTC_260 nsc-65238 3.989 µM 0.0565909721769713 0.478879302512672 no 1600 0.477435513090191 2299 3246252 SGTC_204 PMA1.184 62.41 µM 0.0546328271395931 0.47953441590743 no 1601 0.478215492764238 2316 2252213 YGL008C PMA1 SGTC_2112 5488546 200 µM 0.0542099012765041 0.479675916525624 no 1602 0.478383966103961 2315 600757 SGTC_2972 9093619 59.92 µM 0.0540671347595776 0.479723683278849 no 1603 0.478440838297033 2283 25236256 SGTC_2963 9082507 9 µM 0.0514111275519184 0.480612381271296 no 1604 0.479498958998024 2284 16459611 SGTC_2188 6126565 140.678 µM 0.0509482491412352 0.480767270020859 no 1605 0.479683379075519 2304 874518 SGTC_2466 5983409 37.09 µM 0.050800479726435 0.480816717354959 no 1606 0.479742254303 2195 2879657 SGTC_2819 7996655 46.38 µM 0.0507908561662481 0.48081993764862 no 1607 0.47974608859823 2302 6456960 SGTC_2029 5175081 200 µM 0.0485317260713324 0.481575935547792 no 1608 0.480646240237458 2310 1380876 SGTC_160 3453-0671 289.699 µM 0.047106595505663 0.482052877139339 no 1609 0.481214135360892 2306 5322268 SGTC_837 0091-0265 12.5 µM 0.046930290841891 0.482111881972435 no 1610 0.481284393041952 2276 759367 SGTC_280 3448-3607 3.04 µM 0.0462791958596954 0.482329790828668 no 1611 0.481543860419421 2324 626179 SGTC_717 1532-0246 73.2 µM 0.0458760424762897 0.482464721093492 no 1612 0.481704524700958 2277 9561992 SGTC_648 0375-0473 33.3 µM 0.0448243267778904 0.482816726259191 no 1613 0.482123667306462 2286 1713139 SGTC_2696 st077691 74.316 µM 0.0442433263285377 0.483011190617788 no 1614 0.482355223215518 2286 757133 SGTC_1160 4092-0570 10.5 µM 0.0439789595698533 0.483099677108908 no 1615 0.482460587734134 2305 4994975 SGTC_950 1165-0508 94.1 µM 0.0425280472828486 0.483585328275602 no 1616 0.483038876736319 2274 6148369 SGTC_2854 9024559 71.43 µM 0.0406668034162295 0.484208361699499 no 1617 0.483780763363914 2292 3163529 SGTC_712 r015-0009 80.6 µM 0.0406005262076314 0.484230548075477 no 1618 0.483807182325537 2305 6813872 YLR060W FRS1 SGTC_2186 6124449 200 µM 0.0390843860911857 0.48473809101491 no 1619 0.484411554775885 2312 3834182 YLR033W RSC58 SGTC_1233 0325-0408 14.2 µM 0.0368092734308229 0.485499753676306 no 1620 0.485318539966122 2318 12874 SGTC_361 000s-0510 1.45 µM 0.0364225311865495 0.485629232657818 no 1621 0.485472724403956 2293 660 SGTC_1980 st071811 45.7 µM 0.0359867738725069 0.485775123405021 no 1622 0.48564645252243 2307 4974850 SGTC_654 1124-0271 80.9 µM 0.0355602922064607 0.485917910526069 no 1623 0.485816485255401 2315 5403748 SGTC_2782 7736369 71.43 µM 0.0350030420579529 0.486104481977763 no 1624 0.486038657574875 2301 2950836 YOL077C BRX1 SGTC_1360 1598-0022 39.8 µM 0.0340075552667041 0.486437785826909 no 1625 0.486435562977873 2325 761525 SGTC_1149 3909-7961 23.3 µM 0.0338076638403475 0.486504713612261 no 1626 0.486515262289847 2237 735261 SGTC_440 fluspirilene 35.1 µM 0.0326483927452941 0.486892868995671 no 1627 0.486977489274958 2311 3396 An atypical antipsychotic. SGTC_1414 3917-0015 5.4 µM 0.0314186342652463 0.487304639030633 no 1628 0.487467840246056 2339 6618702 SGTC_404 fumagillin 50 µM 0.0309316937242522 0.487467689057863 no 1629 0.48766200703659 2267 12015870 A methionine aminopeptidase binder. SGTC_98 0074-0023 107.663 µM 0.0307286281953482 0.487535685331289 no 1630 0.487742979970138 2277 3563821 SGTC_1179 1021-1431 9.29 µM 0.0287137713248335 0.488210377297023 no 1631 0.488546436483976 2321 2840958 SGTC_520 3584-0023 682 µM 0.0280925799762503 0.488418395399973 no 1632 0.488794156030327 2214 1340790 SGTC_3320 9137005 35.139 µM 0.0280031733775333 0.488448335213269 no 1633 0.48882981007571 2232 4908713 SGTC_2994 9053520 71.4286 µM 0.0275967905282311 0.488584422481266 no 1634 0.48899187073971 2353 4647384 SGTC_3088 9117578 49.47 µM 0.0272330451166997 0.488706232684788 no 1635 0.48913692964111 2361 678341 SGTC_3298 9116858 71.43 µM 0.026425812563909 0.488976560560374 no 1636 0.48945885294381 2346 2506942 SGTC_2064 5220758 200 µM 0.026091185479174 0.489088622732411 no 1637 0.489592303819749 2320 788518 SGTC_1804 st050076 49.1 µM 0.0257602387383075 0.489199453253362 no 1638 0.489724288103059 2336 3895976 SGTC_933 2914-0560 114 µM 0.0257562623782895 0.489200784898855 no 1639 0.489725873915022 2363 463887 SGTC_489 paxilline 115 µM 0.0213702495842966 0.490669689225353 no 1640 0.491475152768322 2293 105008 A toxic potassium channel blocker. SGTC_2772 vinpocetine 57.06 µM 0.0211370294516704 0.490747799890208 no 1641 0.491568173127836 2358 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_569 4130-2812 160 µM 0.0203354425197017 0.491016272059172 no 1642 0.491887891292424 2381 743552 SGTC_856 0433-0016 11.3 µM 0.0199177346319708 0.491156174841114 no 1643 0.492054498880404 2302 3911780 SGTC_3135 9127742 49.47 µM 0.0194558125943764 0.491310887521578 no 1644 0.492238743402614 2312 3643468 SGTC_2951 9072950 58.06 µM 0.0167366832617602 0.492221637902782 no 1645 0.493323341121779 2385 16488155 SGTC_120 rhodamine 6G 52.259 µM 0.0165345813699998 0.492289331974555 no 1646 0.493403956955458 2384 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1676 st018489 23.4 µM 0.0159782276870342 0.492475683900585 no 1647 0.493625880633689 2330 3696235 SGTC_1031 k035-0009 16 µM 0.0150775741595195 0.492777363302509 no 1648 0.493985146078784 2371 5180959 SGTC_1030 k029-0042 36.7 µM 0.0148947446930323 0.492838603659389 no 1649 0.494058076292992 2286 6080581 SGTC_2378 9074213 121.43 µM 0.0148523352902038 0.492852809090456 no 1650 0.494074993325551 2372 657714 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0146373123550421 0.492924833197823 no 1651 0.494160765741088 2366 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2959 9079155 11 µM 0.0107721481012986 0.494219546138212 no 1652 0.495702617782588 2376 16189457 SGTC_1826 st055655 41.6 µM 0.00979486418865377 0.494546916827484 no 1653 0.496092477025334 2358 676168 SGTC_383 2324-0395 7.37 µM 0.00970491391971446 0.494577048567925 no 1654 0.496128360285158 2375 3146421 SGTC_1327 1436-0082 2.18 µM 0.00913277281324335 0.494768706380861 no 1655 0.496356601435385 2365 15992205 SGTC_2900 5328528 85.29 µM 0.00903411139618629 0.494801756447962 no 1656 0.496395960022327 2380 795359 SGTC_2149 5554786 194.827 µM 0.00900847270138882 0.494810345024792 no 1657 0.496406187965493 2375 745063 YPR165W RHO1 SGTC_2961 9083290 32.55 µM 0.00753871048538755 0.495302697140142 no 1658 0.496992518134647 2395 17741490 SGTC_70 0141-0289 43.283 µM 0.00662685651053776 0.495608160557869 no 1659 0.49735628610169 2359 352408 SGTC_621 3584-0052 32.1 µM 0.0058793462689092 0.49585857213496 no 1660 0.49765449370496 2392 2273927 SGTC_420 mitomycin C 81.9 mM 0.00515403170859229 0.496101549848884 no 1661 0.497943847940202 2397 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_427 1354-0053 47.3 µM 0.00310234683175565 0.496788864281502 no 1662 0.498762344665657 2389 6813657 SGTC_2694 st077685 81.9 µM 0.00284293418353691 0.496875768239603 no 1663 0.498865834881561 2397 2838096 SGTC_3275 9138069 49.47 µM 0.00216276317760622 0.497103628110286 no 1664 0.499137182998602 2378 17617007 SGTC_2873 9040596 71.43 µM 0.00187559401871009 0.497199831157341 no 1665 0.499251746683776 2394 6463863 SGTC_2825 7998094 58.44 µM 0.00150645638810138 0.497323494274395 no 1666 0.499399011080521 2400 2987815 SGTC_1735 st034310 56.75 µM 0.00134561528845577 0.497377377000068 no 1667 0.499463177330283 2392 871153 SGTC_2329 6138490 200 µM -0.00190824089575721 0.498467447109286 no 1668 0.499238722487509 2417 720019 SGTC_2645 abamectin 100 µM -0.00229699956573786 0.498597685568374 no 1669 0.499083630560989 2409 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3187 9109394 49.47 µM -0.00314661482163447 0.498882316587847 no 1670 0.498744684379031 2418 17098090 SGTC_1940 st075990 51.1 µM -0.00403490125834188 0.499179903509921 no 1671 0.49839031165854 2450 1084979 SGTC_1014 4130-3005 69.3 µM -0.00416612257555549 0.49922386431377 no 1672 0.498337962367158 2415 743608 SGTC_1444 4112-3581 28 µM -0.00477286551521103 0.499427131000171 no 1673 0.49809590937659 2416 2877249 SGTC_3082 9117008 49.47 µM -0.00566020858568033 0.49972440259155 no 1674 0.497741915536691 2426 41448529 SGTC_1191 1487-1166 10.6 µM -0.00582533225492952 0.499779721212876 no 1675 0.497676041809855 2431 3955771 SGTC_3093 9117344 49.47 µM -0.006384340923665 0.499966996563283 no 1676 0.497453033775374 2452 24824913 SGTC_1183 1254-0324 198 µM -0.00648285472222522 0.5 no 1677 0.497413733269297 2421 5799357 SGTC_928 2764-0428 58.7 µM -0.00693695582907566 0.499847870074891 no 1678 0.497232577217879 2454 662578 SGTC_2407 paclitaxel 400 µM -0.00759981476164906 0.499625803540697 no 1679 0.496968141753653 2476 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1028 k015-0029 4.8 µM -0.00829430879954284 0.49939313895218 no 1680 0.496691087472948 2418 4588309 SGTC_2357 9067248 200 µM -0.00830207553321511 0.49939053699581 no 1681 0.496687989101184 2420 9150235 SGTC_792 4534-1957 155 µM -0.00862395419765274 0.499282703498566 no 1682 0.496559582691819 2445 1717904 SGTC_1631 benzylvanillin 81.9 µM -0.00938928916536258 0.499026306654554 no 1683 0.496254270605573 2438 75506 SGTC_2387 9077560 195.08 µM -0.0105850836081836 0.498625701314985 no 1684 0.495777241463048 2420 5303272 SGTC_812 4251-0442 148 µM -0.0107593406166653 0.498567323253755 no 1685 0.495707726933626 2419 5723007 SGTC_2565 isoliquiritigenin 100 µM -0.012075590170879 0.498126365901905 no 1686 0.495182653597798 2462 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0122455482962658 0.498069428309774 no 1687 0.495114855128951 2429 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1581 himbacine 57.9 µM -0.0139849312062935 0.497486720920126 no 1688 0.494421001509071 2430 5281825 An alkaloid muscarinic receptor antagonist. SGTC_332 4112-0506 40.9 µM -0.0147830287302595 0.497219353492721 no 1689 0.49410263960739 2433 2790355 SGTC_2740 felodipine 17.08 µM -0.0159906895881781 0.496814782321246 no 1690 0.493620909689514 2438 3333 L-type calcium channel blocker SGTC_1578 josamycin 24.2 µM -0.0188619066798229 0.495852927140994 no 1691 0.492475634098265 2445 5282165 A P450 substrate. SGTC_407 eburnamonine 100 µM -0.0196305825719256 0.49559542525803 no 1692 0.49216903358295 2441 3195 SGTC_1004 4084-0029 199 µM -0.0199497701521393 0.495488499837327 no 1693 0.492041721095842 2456 716894 YLR208W SEC13 SGTC_530 4358-1714 28 µM -0.0206981255899204 0.495237807720668 no 1694 0.491743232131625 2506 1564641 SGTC_2800 7887935 81.82 µM -0.0219018471049469 0.494834576187621 no 1695 0.491263125676394 2470 2961002 SGTC_1591 genipin 88.4 µM -0.022182198245469 0.494740662832345 no 1696 0.491151308919874 2500 442424 A DNA cross-linking agent. SGTC_1174 0739-0097 51.1 µM -0.0222305718295926 0.494724458448951 no 1697 0.491132015409543 2469 728447 SGTC_2052 5265182 7.135 µM -0.0223037658268391 0.494699939637414 no 1698 0.491102822467596 2447 1239884 SGTC_3209 9113616 49.47 µM -0.0229557091507363 0.494481550006505 no 1699 0.490842801303467 2451 16649353 SGTC_2413 inermin 26.06 µM -0.023044811402394 0.494451702434886 no 1700 0.490807264049074 2449 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2035 5154463 94.595 µM -0.0230818680988714 0.494439289150513 no 1701 0.490792484497353 2447 2769623 SGTC_426 0988-0037 14.6 µM -0.0234658879426077 0.494310650168934 no 1702 0.490639324233152 2444 5383008 SGTC_3086 9117350 49.47 µM -0.023533845915407 0.494287885665901 no 1703 0.490612220409509 2460 2679265 SGTC_1710 st031758 61.5 µM -0.023963292896659 0.494144030320263 no 1704 0.490440944159059 2486 5394341 SGTC_248 streptozotocin 5.23457 mM -0.0254349186494164 0.493651073772137 no 1705 0.489854029528018 2481 5300 DNA alkylating agent. SGTC_147 4466-0538 29.23 µM -0.0255513083871738 0.493612086625491 no 1706 0.489807611826504 2527 6742687 YHR072W ERG7 SGTC_73 0327-0325 16.231 µM -0.0258010661379305 0.493528425314664 no 1707 0.489708005739023 2465 53298 SGTC_1278 0874-0585 172 µM -0.0264795414564688 0.493301158001432 no 1708 0.489437425714991 2470 766306 SGTC_1483 3453-0561 55.9 µM -0.0265382645646483 0.493281487758456 no 1709 0.489414006814239 2462 4546991 SGTC_958 1222-0007 33 µM -0.0274183529300134 0.49298669008802 no 1710 0.489063030114907 2475 7312461 SGTC_650 1328-0195 38 µM -0.0276196419563923 0.49291926609988 no 1711 0.48898275781251 2447 2780821 SGTC_2922 7999257 32.47 µM -0.0295366713491444 0.49227714629025 no 1712 0.488218286091975 2459 2988377 SGTC_1849 st056239 19.2 µM -0.0304961837519982 0.491955759608843 no 1713 0.487835668445965 2465 5393181 SGTC_1185 1319-0113 81.3 µM -0.0305442463830886 0.491939661266236 no 1714 0.487816503158471 2501 4672763 SGTC_465 cgp-37157 41 µM -0.030875744539606 0.491828627943173 no 1715 0.487684316875959 2458 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1304 1165-0502 251 µM -0.031094812028972 0.491755252945943 no 1716 0.487596963535855 2480 767425 SGTC_3259 9138485 49.47 µM -0.0311477588871194 0.49173751883838 no 1717 0.487575851022102 2462 17646153 SGTC_823 0417-1665 178 µM -0.0319564787654612 0.491466646925634 no 1718 0.487253379034639 2499 3429856 SGTC_2856 9022925 19.48 µM -0.0337312797586913 0.490872210636574 no 1719 0.486545717759249 2506 4944862 SGTC_2685 mycophenolic acid 18.85 µM -0.0345313335321535 0.490604254187737 no 1720 0.48622672834778 2499 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3314 9135860 59.4275 µM -0.0358212587979927 0.490172237466805 no 1721 0.485712440937132 2468 25252478 SGTC_1958 st076513 41.9 µM -0.0362027266859677 0.49004447992105 no 1722 0.48556035591767 2473 732122 YGL099W LSG1 SGTC_1494 4358-1428 177 µM -0.0368739574354625 0.489819680280393 no 1723 0.485292752288616 2461 1564571 SGTC_2054 5233173 129 µM -0.0379283550927076 0.489466562051979 no 1724 0.484872402607421 2527 6889 SGTC_2196 6573537 42.6665 µM -0.0381829986330542 0.489381283048167 no 1725 0.484770888068072 2502 2903087 SGTC_822 1487-0950 154 µM -0.0393124763950279 0.489003031809608 no 1726 0.484320629790863 2475 1958375 SGTC_397 arbidol 50 µM -0.0396401947834507 0.488893283909649 no 1727 0.484189990902494 2588 131410 A RNA synthesis inhibitor. SGTC_977 1348-1378 135 µM -0.0396711108395558 0.488882930636324 no 1728 0.484177666874585 2469 X977 SGTC_3017 9080681 49.47 µM -0.0399229913332079 0.488798580325337 no 1729 0.484077260639777 2527 16451914 SGTC_2464 5717415 7.67 µM -0.0415045357406489 0.488268960748071 no 1730 0.483446838486752 2490 5285744 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0471413148650619 0.486381519453867 no 1731 0.481200299711198 2513 279621 SGTC_1708 st033234 31.827 µM -0.0473533623888694 0.486310522315434 no 1732 0.481115799356846 2565 674664 SGTC_153 4077-0274 519.67 µM -0.0474385962627857 0.486281984678494 no 1733 0.481081834131643 2500 3121976 SGTC_555 4296-0685 37 µM -0.0489122448847967 0.485788595254416 no 1734 0.480494615268129 2485 2908540 YHR072W ERG7 SGTC_2777 climbazole 1.536 µM -0.0492901443341417 0.485662074950497 no 1735 0.480344036827228 2491 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2828 7998861 71.43 µM -0.0502520990104914 0.485340020166465 no 1736 0.479960747479276 2495 2988188 SGTC_2523 spermine 47.74 µM -0.0509417233185226 0.485109145298902 no 1737 0.479685979125849 2508 1103 A DNA binding polyamine. SGTC_220 paclitaxel 373.376 µM -0.0520826322169618 0.484727198775601 no 1738 0.479231425832637 2514 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2905 7799065 20.05 µM -0.0521121215726805 0.484717326693196 no 1739 0.479219677236291 2517 1296806 SGTC_2876 9059903 25.97 µM -0.052358876453329 0.484634721508625 no 1740 0.479121370490587 2499 6916095 SGTC_458 nppb 133 µM -0.0525436663798467 0.484572860525609 no 1741 0.479047751313873 2520 4549 A chloride channel blocker. SGTC_1691 st019933 84.6 µM -0.0525644221416774 0.484565912270511 no 1742 0.47903948238989 2488 6176082 SGTC_2030 5175110 200 µM -0.0547067226381552 0.483848775539843 no 1743 0.478186056747374 2567 2831986 SGTC_265 mycophenolic acid 32.932 µM -0.0548982121023854 0.483784676804503 no 1744 0.478109778134181 2590 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2815 7968870 71.43 µM -0.0549537311398959 0.483766092570043 no 1745 0.478087662627646 2515 2977326 YHR190W ERG9 SGTC_1092 toremifene 6.32 µM -0.0559326511691087 0.483438418379504 no 1746 0.477697729831671 2492 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2194 5927483 104.545 µM -0.056192224711224 0.4833515331182 no 1747 0.477594337579639 2493 760979 SGTC_744 1594-0068 283 µM -0.056983920686288 0.4830865390855 no 1748 0.477279001880149 2513 668392 SGTC_1746 st038117 42 µM -0.0570729978329988 0.483056723923383 no 1749 0.477243522980094 2565 2898218 SGTC_1117 retinoic acid 1.10837 µM -0.057523387237495 0.482905974779754 no 1750 0.477064138314693 2522 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0586128751282157 0.482541324114181 no 1751 0.476630227722819 2539 23847180 SGTC_1864 st057645 30.4 µM -0.0589022906597276 0.482444459425751 no 1752 0.476514966769469 2505 688666 SGTC_17 0960-0276 49.807 µM -0.0636376041932341 0.480859745337797 no 1753 0.474629394297636 2519 6821114 SGTC_858 0438-0351 2.77 µM -0.0650371308531428 0.480391438276343 no 1754 0.474072218338317 2536 2799119 SGTC_2144 5628481 200 µM -0.0650809591954441 0.480376772949935 no 1755 0.474054770324519 2523 2818399 SGTC_2143 5623677 140.463 µM -0.0655272810162951 0.48022743148722 no 1756 0.473877092949167 2504 5375313 SGTC_589 1227-0070 34.1 µM -0.0663197413046859 0.479962277253184 no 1757 0.473561633267709 2598 2841384 SGTC_137 0438-0332 85.389 µM -0.0670177640232806 0.479728728815555 no 1758 0.473283780673709 2520 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2887 9044784 58.44 µM -0.0675603199706521 0.479547202142974 no 1759 0.473067821634612 2538 6465546 SGTC_599 1935-0052 86.5 µM -0.0676371796046778 0.479521487029077 no 1760 0.473037229054651 2530 9557311 SGTC_1215 3852-0577 11.2 µM -0.070475544277259 0.478571909076649 no 1761 0.471907582490213 2648 2884876 SGTC_789 1309-1135 70.6 µM -0.0710541967402103 0.478378335022599 no 1762 0.471677310844547 2544 3092424 SGTC_49 0717-0965 32.132 µM -0.0756461266235026 0.476842401554648 no 1763 0.469850318916171 2810 5889349 YGL099W LSG1 SGTC_817 1391-0715 46 µM -0.0756855484824399 0.476829216975233 no 1764 0.469834636826669 2597 1353946 SGTC_894 0960-0238 55.9 µM -0.0761999259798767 0.476657186551117 no 1765 0.469630020789625 2508 6741907 YDL195W SEC31 SGTC_2221 6807166 181.081 µM -0.0767051241253553 0.476488230339822 no 1766 0.469429064045502 2554 674925 SGTC_721 1187-1332 279 µM -0.076961417019566 0.476402518503177 no 1767 0.469327119326395 2523 25730 SGTC_2831 7999036 19.48 µM -0.0771177229388191 0.476350245769827 no 1768 0.469264947059782 2720 2988270 SGTC_1697 st025554 27.742 µM -0.0798188649517775 0.475446979224807 no 1769 0.468190660066533 2542 1269519 SGTC_15 0266-0086 27.098 µM -0.0805522316271286 0.475201761728302 no 1770 0.467899028163937 2556 1712902 YIL048W NEO1 SGTC_2930 9013230 14.89 µM -0.0807076793912409 0.475149785506429 no 1771 0.467837214735839 2598 2995857 SGTC_732 3970-1727 52.7 µM -0.0831508700664724 0.474332925279271 no 1772 0.466865788697458 2607 1275699 SGTC_2954 9074818 52.69 µM -0.0838517491996827 0.474098612008463 no 1773 0.46658715147334 2621 16648742 SGTC_1621 st003705 32.4 µM -0.0845383855370419 0.473869068982935 no 1774 0.466314192406439 2548 24207032 SGTC_2003 4023581 200 µM -0.0847905064408168 0.473784786955497 no 1775 0.466213970561395 2637 16641307 SGTC_909 3448-9333 149 µM -0.0850411056629049 0.47370101477703 no 1776 0.466114355730767 2556 3344074 SGTC_1895 st058434 18.3 µM -0.085375160803621 0.473589346140219 no 1777 0.465981569928523 2559 5393175 SGTC_839 0122-0028 230 µM -0.0865779840928605 0.473187281159045 no 1778 0.465503483162498 2562 759448 SGTC_1789 tunicamycin 25 nM -0.0870582404251643 0.473026754584119 no 1779 0.465312609309958 2642 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_217 ketoconazole 989 nM -0.0881126523417941 0.472674330836748 no 1780 0.464893570189793 2556 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1203 3992-3522 103 µM -0.0884314302220467 0.472567787590666 no 1781 0.464766890718757 2687 5322312 SGTC_181 1447-1644 8.07 µM -0.0891136707489382 0.472339772978157 no 1782 0.464495786467176 2568 534600 SGTC_1163 k060-0048 49.9 µM -0.0895845953277449 0.472182388483055 no 1783 0.464308663163948 2552 6809982 SGTC_1563 conessine 56.1 µM -0.0901897700624025 0.471980143538504 no 1784 0.464068206752245 2616 441082 An anti-amoebic, histamine inhibitor. SGTC_688 0527-0193 473 µM -0.0908319178058598 0.471765550387751 no 1785 0.463813074065366 2611 4007154 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0908689554549831 0.471753173383018 no 1786 0.463798359034121 2562 442882 SGTC_3297 9117502 71.43 µM -0.091027118510663 0.471700319771625 no 1787 0.463735521523886 2550 7453720 SGTC_396 dithiazanine 1.25 µM -0.0915690482296563 0.471519226001128 no 1788 0.46352022201831 2587 10578 An antihelmenthic. SGTC_532 1548-0774 215 µM -0.0924330051660215 0.471230534300928 no 1789 0.463177008667818 2756 5932993 SGTC_1947 st076332 61.6 µM -0.0927759372560578 0.471115947531246 no 1790 0.463040783916189 2571 24208416 SGTC_1554 st069299 38.7 µM -0.0928977019848019 0.471075261837995 no 1791 0.462992415702375 2633 24207999 SGTC_3110 9122132 49.47 µM -0.0929555202077511 0.47105594292981 no 1792 0.462969448946099 2719 918317 SGTC_2275 7947463 200 µM -0.0933860292397711 0.470912098307291 no 1793 0.46279844453254 2546 1225414 SGTC_1953 st076800 12.1 µM -0.0937410444806887 0.470793481040925 no 1794 0.462657432515413 2608 297591 SGTC_2400 5203494 178.7 µM -0.0938947982887417 0.470742109806553 no 1795 0.46259636297395 2568 6777674 SGTC_1562 morin hydrate 59.1 µM -0.0943469075991163 0.470591056772766 no 1796 0.462416794594647 2699 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1923 st058458 19.1 µM -0.0944756684785596 0.470548037592557 no 1797 0.462365654861234 2619 3534982 SGTC_3137 9097352 49.47 µM -0.0962214939931375 0.469964789108341 no 1798 0.461672330140445 2736 44120435 SGTC_1931 st074438 57.1 µM -0.0967360029527841 0.469792913279411 no 1799 0.461468023837899 2540 2787313 SGTC_2797 7859098 81.82 µM -0.0979547866063335 0.46938579137675 no 1800 0.460984097849909 2605 972681 SGTC_769 0302-0231 76 µM -0.0980618116366797 0.469350042309828 no 1801 0.460941605613414 2628 571869 YER009W NTF2 SGTC_2603 homopterocarpin 100 µM -0.0982206219951126 0.469296996089045 no 1802 0.460878553827167 2662 101795 A weak amylase inhibitor. SGTC_1739 st037196 92.5 µM -0.0982569231477436 0.469284870766561 no 1803 0.460864141476385 2617 612214 SGTC_2739 tacrine 100.86 µM -0.100454685824069 0.468550826865634 no 1804 0.459991678136244 2669 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1880 MG-132 525 µM -0.100966106330765 0.468380029712658 no 1805 0.459788682937907 2624 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_337 1315-0038 354 µM -0.101413723499666 0.468230545491629 no 1806 0.459611021431141 2620 1626437 SGTC_1833 st055984 71 µM -0.102151340113892 0.467984224139444 no 1807 0.459318275296384 2626 676288 SGTC_2807 7945238 51.95 µM -0.104112012884025 0.467329532507578 no 1808 0.458540228882483 2691 17148797 SGTC_1512 0259-0544 12.2 µM -0.104498138489706 0.467200610998939 no 1809 0.458387022731565 2597 18476 SGTC_3096 9117468 49.47 µM -0.10603250214338 0.466688344279695 no 1810 0.457778282278053 2597 41316311 SGTC_1756 st041558 35.5 µM -0.106750607973549 0.466448614465256 no 1811 0.457493416299771 2670 3955792 SGTC_804 1595-0054 20.9 µM -0.107019318928394 0.466358912111324 no 1812 0.457386826741905 2602 761523 Stimulates phospholipase C. SGTC_3150 9097574 49.47 µM -0.108108917390617 0.465995194792365 no 1813 0.456954647280365 2630 17217476 SGTC_3265 9137266 49.47 µM -0.112105672906737 0.46466128894696 no 1814 0.455369809727025 2570 17224265 SGTC_170 4197-0004 226 µM -0.112496259991509 0.464530952668342 no 1815 0.455214967507522 2718 218692 SGTC_3311 9131146 2.8755 µM -0.112544293135071 0.464514924594465 no 1816 0.455195925978653 2662 4900406 YPR165W RHO1 SGTC_1520 flindersine 88 µM -0.114888053536145 0.463732910802521 no 1817 0.454266927144065 2887 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1841 st054148 70 µM -0.11546842062524 0.463539288357868 no 1818 0.454036924856371 2669 675442 SGTC_2663 amphotericin b 100 µM -0.116268120099454 0.463272506258646 no 1819 0.453720025348951 2616 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1848 st056003 16.4 µM -0.116304456450703 0.463260384736264 no 1820 0.453705626923336 2582 146492 SGTC_1625 st003711 30.1 µM -0.116681263316434 0.463134686928006 no 1821 0.453556319274963 2720 24207034 YER133W GLC7 SGTC_211 3455-0679 143.504 µM -0.116732926338193 0.46311745311093 no 1822 0.453535848597944 2666 748649 SGTC_1162 k048-0130 20.1 µM -0.118214775647327 0.462623165511265 no 1823 0.452948741387959 2625 6797406 SGTC_683 panaxydol 45 µM -0.119883108644674 0.462066743264942 no 1824 0.452287872656799 2686 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_762 1165-0429 115 µM -0.120031635070552 0.4620172103294 no 1825 0.452229043977757 2672 5967793 SGTC_2986 9022445 71.43 µM -0.120580736687596 0.461834092380605 no 1826 0.452011563696743 2646 6459286 SGTC_1891 st059073 26.2 µM -0.122533387716585 0.461182975525075 no 1827 0.451238302817549 2720 688754 SGTC_1504 k297-0033 30 µM -0.122631805230205 0.461150160674035 no 1828 0.451199333796746 2592 4388117 SGTC_3229 9132204 49.47 µM -0.12264148032398 0.461146934771 no 1829 0.451195502909149 2617 17682924 SGTC_3058 9093861 49.47 µM -0.123331146238815 0.460916990589305 no 1830 0.450922438982973 2748 17217477 SGTC_2301 7769476 200 µM -0.123444647875035 0.460879148819687 no 1831 0.450877501761717 2695 977820 SGTC_680 0417-1641 114 µM -0.123747397458451 0.460778212977706 no 1832 0.450757641152104 2624 2835990 SGTC_164 4100-3994 89.624 µM -0.123808206091511 0.46075793985855 no 1833 0.450733567143808 2615 4615967 SGTC_2412 st077135 33.4 µM -0.124347852062928 0.460578030618516 no 1834 0.450519930404615 2918 13258915 SGTC_2261 9010538 184.68 µM -0.125379209026212 0.460234215364467 no 1835 0.450111673507202 2747 6457250 SGTC_301 4119-0100 24.5 µM -0.125438428870485 0.460214474616884 no 1836 0.450088233260869 2637 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_81 0411-0046 9.971 µM -0.125448007152283 0.460211281736186 no 1837 0.450084442026378 2599 12925265 SGTC_821 1114-0266 29.2 µM -0.125927616343058 0.460051409277143 no 1838 0.449894611002065 2697 3123235 SGTC_2346 9031566 143.75 µM -0.128423891401805 0.459219408255246 no 1839 0.448906762548994 2741 4771086 SGTC_1350 1495-0454 146 µM -0.128916361339331 0.459055290471566 no 1840 0.448711915112705 2767 1069057 SGTC_2056 5235370 200 µM -0.129488252911706 0.458864713835625 no 1841 0.448485659757902 2675 5511916 SGTC_1900 st060200 72.8 µM -0.129663833781365 0.458806205318461 no 1842 0.44841619870382 2613 688945 SGTC_2526 patulin 37.61 µM -0.132292113535969 0.457930495443118 no 1843 0.447376622518903 2757 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_131 0141-0277 33.849 µM -0.133191310201094 0.457630941046356 no 1844 0.44702104153608 2780 1547771 SGTC_2306 7482397 179.52 µM -0.135234148919269 0.456950488511233 no 1845 0.446213374075004 2759 891448 SGTC_1548 st061468 90.8 µM -0.135429590570792 0.456885395110522 no 1846 0.446136114876363 2717 390799 SGTC_798 1287-0182 476 µM -0.137346046483225 0.456247165741876 no 1847 0.445378637721423 2647 1649755 SGTC_1133 3473-0247 50 µM -0.139518979451519 0.455523659502958 no 1848 0.44452002959048 2736 711311 SGTC_1068 loratadine 26.9 µM -0.139599612855714 0.455496814387419 no 1849 0.444488173261456 2704 3957 A H1 histamine antagonist. SGTC_2976 9009005 19.48 µM -0.139919263282737 0.455390395820355 no 1850 0.444361890555022 2801 2993148 SGTC_2829 7992743 58.44 µM -0.139941457667836 0.455383006946446 no 1851 0.444353122539089 2800 16462845 SGTC_2386 9075165 157.42 µM -0.140081315046915 0.45533644649198 no 1852 0.444297871726138 2637 16452277 SGTC_1568 digitonin 820 nM -0.140251535968684 0.45527977842229 no 1853 0.444230627222464 2701 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2745 rifampicin 24.3 µM -0.140626459664218 0.455154966176371 no 1854 0.444082522081762 2741 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3210 9128157 49.47 µM -0.141800801207467 0.454764056116705 no 1855 0.443618675596596 2806 17590849 SGTC_2639 lactacystin 53 µM -0.141957283311778 0.454711970286305 no 1856 0.443556873438255 2754 3870 A proteasome inhibitor. SGTC_2648 atorvastatin 78.68 µM -0.142274791123994 0.45460628865866 no 1857 0.443431478858691 2712 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3293 9120939 62.045 µM -0.143496054368041 0.454199824461998 no 1858 0.442949213580731 2790 934087 SGTC_708 3448-5400 146 µM -0.144606778079109 0.453830191970456 no 1859 0.442510672678528 2664 3462195 SGTC_1167 k781-0610 148 µM -0.145809090685707 0.453430125122862 no 1860 0.442036049638486 2724 4525169 SGTC_2724 maprotiline 69.64 µM -0.146368728185898 0.453243923081548 no 1861 0.441815156351114 2687 4011 A tricyclic antidepressant. SGTC_357 1325-0123 420 µM -0.146929239540845 0.453057440595394 no 1862 0.441593936282273 2726 1098503 SGTC_774 k060-0086 136 µM -0.146965293269333 0.453045445850792 no 1863 0.441579707383789 2650 5911235 SGTC_1177 0983-0204 23.6 µM -0.147005893781315 0.453031938484334 no 1864 0.441563684150312 2771 766818 SGTC_2369 9071472 200 µM -0.147221558327133 0.452960190052921 no 1865 0.441478572458728 2813 17296037 SGTC_3269 9137823 49.47 µM -0.14772119910063 0.452793972799514 no 1866 0.44128140036097 2669 17682936 SGTC_1142 3253-1408 9.78 µM -0.147780730410729 0.452774168860115 no 1867 0.441257908625265 2647 256655 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.1479508409942 0.45271757979584 no 1868 0.441190782183131 2647 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1831 st055328 12 µM -0.147974844362938 0.452709594901538 no 1869 0.441181310476079 2747 1103068 SGTC_1038 k292-0204 154 µM -0.148211430261786 0.452630893913986 no 1870 0.441087955700496 2653 4454212 SGTC_1392 3455-1037 33.9 µM -0.14978688115491 0.452106863194057 no 1871 0.440466379952333 2811 981132 SGTC_3140 9094243 49.47 µM -0.150272774648002 0.451945260781691 no 1872 0.440274705871802 2635 19291112 SGTC_65 0798-0905 34.986 µM -0.15078675890232 0.45177432438143 no 1873 0.440071965849074 3057 3602145 SGTC_2606 farnesol 9.78 µM -0.151031935062596 0.451692788980047 no 1874 0.43997526215312 2800 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1176 0848-0131 83.3 µM -0.151531193091798 0.451526762811801 no 1875 0.439778353199897 2765 6769040 SGTC_234 nsc-17383 10.7 µM -0.151808312661153 0.451434611515944 no 1876 0.439669062786957 2712 408974 SGTC_141 0443-0274 32.331 µM -0.151941267127259 0.451390400747957 no 1877 0.439616629837525 2763 1627241 SGTC_2568 diosmetin 100 µM -0.153199803346067 0.450971935137444 no 1878 0.439120356374404 2673 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1398 3558-0053 112 µM -0.156772421267609 0.44978433149974 no 1879 0.437712104346715 2684 4532369 SGTC_3306 9127676 59.7925 µM -0.157622301434552 0.449501881567249 no 1880 0.437377214623997 2747 41905287 SGTC_1434 4073-0095 163 µM -0.157956603073389 0.449390786465555 no 1881 0.437245497529071 2694 24133745 SGTC_3245 9134821 49.47 µM -0.158361068973821 0.449256379684569 no 1882 0.437086144542349 2681 17014901 SGTC_1003 4049-0218 100 µM -0.159922732280215 0.448737483077589 no 1883 0.436470970606852 2839 295161 SGTC_483 fpl-64176 144 µM -0.160379812518885 0.448585624771571 no 1884 0.436290945523034 2694 3423 SGTC_316 k060-0003 58.6 µM -0.161157320020895 0.448327326452994 no 1885 0.43598474767072 2826 6152314 SGTC_1288 0973-0013 65.5 µM -0.161701056912828 0.448146702845016 no 1886 0.435770636099784 2780 4315430 SGTC_790 1575-0012 79.1 µM -0.163731099306232 0.447472439655017 no 1887 0.43497141710535 2843 378741 YLR208W SEC13 SGTC_669 0108-0021 26.2 µM -0.163901453727542 0.447415864601037 no 1888 0.434904361334262 2641 17201 SGTC_2738 aclarubicin 5.55 µM -0.164578100697011 0.447191159325147 no 1889 0.434638034629161 2774 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1469 k284-2957 126 µM -0.165293917152967 0.446953464846565 no 1890 0.434356323187601 2726 23884841 SGTC_1794 st048918 76.9 µM -0.166504461627515 0.446551534062526 no 1891 0.43387998615601 2665 672303 SGTC_2891 9063876 19.48 µM -0.168037485864502 0.446042610840317 no 1892 0.433276894448132 2780 6472478 SGTC_2626 ethyl orsellinate 100 µM -0.168746774487444 0.445807175928788 no 1893 0.432997912795101 2709 75653 A natural product. SGTC_2699 st077704 54.6 µM -0.169109954738336 0.445686632521215 no 1894 0.432855077478391 2759 645852 SGTC_373 0844-0104 25.9 µM -0.169260741099446 0.445636586390412 no 1895 0.432795777221811 2815 5375804 SGTC_1192 1488-0095 21.4 µM -0.172971397706332 0.444405290974186 no 1896 0.431336955019758 2780 915875 SGTC_2244 6635614 200 µM -0.173076854726515 0.444370305287489 no 1897 0.431295508816864 2674 836499 SGTC_2952 9073731 13.78 µM -0.173430093456431 0.444253120425128 no 1898 0.431156686170129 2726 16457353 SGTC_2099 5377090 177.372 µM -0.173953358878048 0.444079539171175 no 1899 0.430951058751968 2795 2243829 SGTC_924 2046-0044 21.3 µM -0.175076889396612 0.44370687007791 no 1900 0.430509608688724 2698 3623589 SGTC_1474 0330-0125 5.35 µM -0.176119913617208 0.443360949042574 no 1901 0.430099868324819 2757 X1474 SGTC_1190 1486-1332 13 µM -0.176183447623754 0.443339879256184 no 1902 0.430074912130566 2696 4150046 SGTC_1782 st039423 80.636 µM -0.176453563965413 0.443250302346705 no 1903 0.42996881339615 2773 2068169 SGTC_113 0099-0221 2.5 µM -0.17739075343219 0.442939530870863 no 1904 0.429600734917085 2790 89219 SGTC_1859 st055998 20 µM -0.178030919897177 0.442727272212833 no 1905 0.429349346524598 2728 676301 SGTC_476 mead acid 10 µM -0.179092177540208 0.442375429472919 no 1906 0.428932662063422 2720 5312531 An omega 9 fatty acid. SGTC_954 1189-0853 2.85 µM -0.179376241887405 0.442281260250101 no 1907 0.428821142525929 2671 2828194 SGTC_2430 5571206 200 µM -0.179888548829074 0.442111435335642 no 1908 0.428620032631251 2852 1731771 SGTC_2203 7227154 166.4 µM -0.180369243603142 0.441952099229901 no 1909 0.428431349179738 2724 896304 SGTC_638 3970-0837 4.09 µM -0.181171721061381 0.441686122616732 no 1910 0.42811639529754 2752 4118451 YLR208W SEC13 SGTC_3191 9110352 49.47 µM -0.181188795790401 0.441680463579653 no 1911 0.428109694357245 2681 17122424 SGTC_1043 0916-0009 19.3 µM -0.181222303599867 0.44166935820017 no 1912 0.428096544350505 2793 3101130 SGTC_805 3852-0218 479 µM -0.181672115010879 0.441520283174756 no 1913 0.427920025385325 2730 6615355 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.18211551621554 0.441373340706513 no 1914 0.427746036087105 2728 97141 SGTC_1799 st045822 46.1415 µM -0.183697958412556 0.440848987756299 no 1915 0.427125205302868 2824 3674992 SGTC_1453 4237-0541 195 µM -0.185752449911828 0.440168372895625 no 1916 0.426319447465781 2762 739892 SGTC_733 4069-0007 56.1 µM -0.186290092591472 0.439990290964126 no 1917 0.426108638220501 2748 5717425 YNL287W SEC21 SGTC_850 0388-0143 75.9 µM -0.186433191073565 0.439942894884791 no 1918 0.426052532980413 2748 67273 SGTC_1649 st011737 51.3 µM -0.186913633058282 0.439783772547137 no 1919 0.425864174970902 2775 1761035 SGTC_3307 9126885 69.2785 µM -0.187409012119599 0.439619713236668 no 1920 0.425669978569262 2743 24824909 SGTC_1257 0669-0121 16 µM -0.187460280176488 0.439602734907041 no 1921 0.425649881711374 2847 4307855 SGTC_185 k048-0037 25.491 µM -0.18765996180415 0.439536607840858 no 1922 0.425571609213395 2788 6827589 SGTC_3075 9116269 49.47 µM -0.187891909904582 0.439459797447093 no 1923 0.425480692376791 2920 17015205 YNL244C SUI1 SGTC_1700 st030840 7.9285 µM -0.190045885612546 0.438746610376745 no 1924 0.424636587086593 2854 5499307 SGTC_912 3474-0017 2.18 µM -0.191809936708296 0.438162676372244 no 1925 0.423945543561583 2901 3360550 SGTC_2111 5486399 200 µM -0.191948635912372 0.438116770025388 no 1926 0.423891219881747 2745 689674 SGTC_1252 0493-0875 34.8 µM -0.192298376832715 0.438001017270379 no 1927 0.42375424488635 2726 3960963 SGTC_487 nimodipine 119 µM -0.194214520244981 0.437366931152646 no 1928 0.423003956912753 2826 4497 L-type voltage-gated calcium channels inhibitor SGTC_59 0330-0160 1.33 µM -0.194645936472995 0.437224189933052 no 1929 0.422835069338436 2759 4293482 SGTC_1265 0819-1001 68.8 µM -0.195516605832938 0.436936139428245 no 1930 0.422494269479748 2716 3106768 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.196172450223584 0.436719183252495 no 1931 0.422237595309264 2716 6708630 An antioxidant. SGTC_1656 st012921 11 µM -0.196927489007213 0.436469436712693 no 1932 0.421942140878112 2873 6732821 SGTC_346 4513-0042 7.16 µM -0.196983513716283 0.436450906252476 no 1933 0.421920219582675 2759 2827372 SGTC_1606 st000094 49.2 µM -0.197268526862933 0.436356638850943 no 1934 0.421808703654152 2748 1242210 SGTC_200 k038-0079 37.545 µM -0.197367944692618 0.436323757496872 no 1935 0.421769806320914 2786 3436683 SGTC_2227 7312221 64.1025 µM -0.198275482951602 0.436023619566535 no 1936 0.421414766326837 2774 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_283 0987-0079 11.7 µM -0.198673515970215 0.435891995067461 no 1937 0.42125907110966 2838 411556 SGTC_1077 5-fluorocytosine 377 nM -0.19974734852872 0.435536927641901 no 1938 0.420839090567988 2829 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3216 9129716 49.47 µM -0.204368382024775 0.434009559177098 no 1939 0.419032818115156 2813 8056934 SGTC_1422 4031-0024 15.5 µM -0.204393172494344 0.434001367935028 no 1940 0.419023132565937 2778 782427 SGTC_107 0358-0022 2.6945 µM -0.205203022766472 0.433733793626229 no 1941 0.418706753936238 2839 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3070 9117005 49.47 µM -0.205835084574329 0.433524981668789 no 1942 0.418459867219003 2763 8779016 SGTC_366 0181-0206 4.31 µM -0.206785408646621 0.433211061502764 no 1943 0.418088726039862 2908 274874 SGTC_1001 4048-4355 44.4 µM -0.206881297427775 0.43317938893755 no 1944 0.418051281517321 2778 21824233 SGTC_1060 3448-7350 82 µM -0.207385645946924 0.433012807057643 no 1945 0.417854345901033 2885 570178 SGTC_959 1222-0044 107 µM -0.208267629479809 0.432721524278377 no 1946 0.417510002690256 2867 6083612 SGTC_2690 usnic acid 100 µM -0.208686105373991 0.432583331729717 no 1947 0.417346643818902 2976 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1924 st058459 75.1 µM -0.209584976884557 0.432286526892322 no 1948 0.416995802970692 2758 688683 SGTC_1241 0364-0022 50.8 µM -0.210143429058172 0.432102146792489 no 1949 0.416777865335723 2843 4563895 SGTC_324 1315-0088 19.6 µM -0.210154580708638 0.432098465083476 no 1950 0.416773513630927 2851 6787421 SGTC_1079 idarubicin 2.36 µM -0.211605185184379 0.431619599495455 no 1951 0.416207531872438 2792 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_418 lividomycin a 100 µM -0.212409439696884 0.431354146658867 no 1952 0.415893810994217 2806 72394 An antibiotic. SGTC_2683 piperine 63.03 µM -0.213035881626014 0.431147404245957 no 1953 0.415649487763395 2806 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1884 5633444 25 µM -0.214018641171864 0.430823105621707 no 1954 0.415266260204856 2926 5724239 SGTC_1618 st003135 44.5 µM -0.214760244814459 0.430578416359886 no 1955 0.414977124844224 2717 1270615 SGTC_558 k064-0027 21.3 µM -0.215602123499774 0.430300674039151 no 1956 0.414648950208631 2904 5088526 SGTC_1893 st059353 36.1 µM -0.216699150229639 0.429938808153839 no 1957 0.414221405144328 2834 3112488 SGTC_2147 5545932 89.7195 µM -0.2168956507402 0.429873996584774 no 1958 0.414144833568249 2819 797404 SGTC_3018 9082602 49.47 µM -0.218180907513077 0.429450128293364 no 1959 0.41364408017523 2775 17332089 SGTC_343 4130-2827 29.8 µM -0.218298457199088 0.42941136531762 no 1960 0.413598288226184 2837 1118244 SGTC_3077 9117319 49.47 µM -0.218479459322561 0.429351679709735 no 1961 0.413527780424911 2768 17154678 SGTC_2847 9005661 71.43 µM -0.218686661432602 0.429283356616146 no 1962 0.413447070069904 2809 2991449 SGTC_385 1494-0393 12.4 µM -0.218777643065073 0.429253356883375 no 1963 0.413411631625378 2837 3090647 SGTC_692 k241-0027 77.8 µM -0.218843801391071 0.429231542494006 no 1964 0.413385862601426 2954 3600480 SGTC_16 erodoxin 22.806 µM -0.219676149788119 0.428957110685704 no 1965 0.413061690331922 2846 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_509 pifithrin 175 µM -0.221538153010668 0.428343318115057 no 1966 0.41233671635503 2821 4817 A p53 inhibitor. SGTC_2546 rhodinyl acetate 100 µM -0.222867159942251 0.427905328869111 no 1967 0.411819448072881 2836 6708682 SGTC_1328 1441-0025 69.2 µM -0.224408190121133 0.427397576198616 no 1968 0.411219849199643 2779 4562601 SGTC_2139 5578692 56.4705 µM -0.226202245770695 0.426806605911956 no 1969 0.410522062002701 2892 650991 YMR113W FOL3 SGTC_2515 chrysin 20.77 µM -0.226511397937997 0.426704786302848 no 1970 0.410401847656935 2916 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3101 9120531 49.47 µM -0.227170273361091 0.426487801256435 no 1971 0.410145670930332 3020 24824904 SGTC_441 propafenone 146 µM -0.22721413619601 0.426473356857707 no 1972 0.41012861802322 2779 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2034 5197015 53.07 µM -0.227465660590159 0.426390529673899 no 1973 0.410030834144023 2953 780676 SGTC_2141 5621638 7.665 µM -0.227957498023233 0.426228576598566 no 1974 0.409839641138707 2938 2856238 SGTC_1653 st012112 65 µM -0.228070071519771 0.426191509952685 no 1975 0.409795883218306 2974 720429 SGTC_2513 baicalein 25.65 µM -0.229555477098551 0.425702477307412 no 1976 0.409218603535598 2855 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2983 9022671 12.99 µM -0.229558846328754 0.425701368202209 no 1977 0.409217294360145 3009 6405161 SGTC_2743 auranofin 4.32 µM -0.230129329231125 0.425513581397919 no 1978 0.408995637502251 2845 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_127 0180-0333 59.125 µM -0.230796026951214 0.425294144814504 no 1979 0.408736633976075 2783 771601 SGTC_3338 9144300 39.5675 µM -0.232143383156051 0.424850747315052 no 1980 0.408213325103873 2884 4901274 SGTC_464 bw-b 70c 158 µM -0.23224326718365 0.424817880551501 no 1981 0.40817453696948 2950 5353454 SGTC_2866 9034245 58.44 µM -0.233650890062369 0.424354758994759 no 1982 0.407628008239545 2896 6462273 SGTC_474 dl-dihydrosphingosine 5 µM -0.233733211947535 0.424327677523346 no 1983 0.407596051200502 2969 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1995 st072814 61.1 µM -0.233936097735727 0.424260935610452 no 1984 0.407517294343793 2837 5769371 SGTC_891 0929-0073 133 µM -0.235380295375182 0.423785910920447 no 1985 0.406956789250465 2958 5603632 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.23564361653674 0.423699311384169 no 1986 0.406854612623038 3020 94937 An inhibitor of serotonin biosynthesis. SGTC_2984 9022109 38.96 µM -0.235805174525279 0.423646180953735 no 1987 0.406791926342605 2906 6459207 SGTC_2212 7123476 200 µM -0.237416869279671 0.42311623047376 no 1988 0.406166702006189 2850 1085715 SGTC_2734 clemastine 41.6 µM -0.238189223143381 0.422862317661572 no 1989 0.405867167651844 2817 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1496 4469-0713 57.4 µM -0.2413122067487 0.421835958595598 no 1990 0.404656575393276 2950 746691 SGTC_1505 k297-0037 20.6 µM -0.242821749612314 0.421340041747007 no 1991 0.404071742992903 2851 4089396 SGTC_2552 juarezic acid 87.02 µM -0.243085368309133 0.421253450187132 no 1992 0.403969632858785 2799 1549512 SGTC_2318 6029776 164 µM -0.243152816050877 0.421231296053232 no 1993 0.403943508684022 3017 818325 SGTC_2883 9059145 45.46 µM -0.2432901811286 0.421186177384624 no 1994 0.403890305124639 2780 16476510 SGTC_1902 st060212 70.5 µM -0.246421809103608 0.420157850788906 no 1995 0.402677862718462 2847 688944 SGTC_2331 7980721 200 µM -0.246734586230969 0.420055174579234 no 1996 0.402556818981481 2917 2981221 SGTC_3194 9111903 49.47 µM -0.247037569704335 0.419955718547223 no 1997 0.402439574263615 3037 17087251 SGTC_1795 st049545 62.3 µM -0.24714178512446 0.419921510429633 no 1998 0.402399248324345 2882 5291882 SGTC_2085 5307070 144.047 µM -0.249528548012571 0.419138235214569 no 1999 0.401475980505831 2823 2840351 SGTC_705 1124-0212 310 µM -0.249634152306084 0.419103585934822 no 2000 0.401435142422138 2963 9554485 SGTC_3253 9135987 49.47 µM -0.250593747835371 0.418788766782901 no 2001 0.40106410801169 2973 4182430 SGTC_1442 4112-3290 3 µM -0.252245643174769 0.418246943396429 no 2002 0.400425600125294 2853 704353 SGTC_279 1273-0055 2.93 µM -0.254806164821791 0.417407396522127 no 2003 0.399436406783959 2917 2847562 SGTC_1810 st050138 53 µM -0.261655272408443 0.415163562946928 no 2004 0.396793613407298 2958 3444541 SGTC_1690 st023502 41.2 µM -0.262726452919628 0.414812882019804 no 2005 0.39638071317363 2951 24207482 SGTC_1018 4259-0013 28.1 µM -0.263610434846872 0.414523536894186 no 2006 0.396040058512662 3011 6801262 SGTC_2757 clomiphene 4.22 µM -0.272137205308717 0.411734956352101 no 2007 0.392758261495539 3111 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_993 3909-8757 62.7 µM -0.272322466941976 0.411674417612772 no 2008 0.392687041331334 2921 4288324 YLR208W SEC13 SGTC_3098 9119039 49.47 µM -0.272833662626857 0.411507382912969 no 2009 0.392490540921321 2866 17161528 SGTC_1318 1280-3875 124 µM -0.273543668427642 0.411275413032695 no 2010 0.392217664625401 2948 373245 SGTC_1284 0929-0043 16 µM -0.278044486747884 0.409805650768502 no 2011 0.390489104560485 2960 1239883 SGTC_819 1013-0258 27.7 µM -0.278163159440924 0.409766914718649 no 2012 0.3904435568744 2915 5753198 SGTC_1675 st018485 24.5 µM -0.279251075343514 0.409411848297688 no 2013 0.390026074752456 2968 3323024 SGTC_2532 xanthone 78.9 µM -0.27963744337401 0.409285766052294 no 2014 0.389877838503748 3000 7020 An insecticide. SGTC_518 1021-0119 62.6 µM -0.281150135417277 0.408792224490145 no 2015 0.389297624392361 2945 1097762 SGTC_1674 st016616 23.6 µM -0.281976111786876 0.408522796600759 no 2016 0.38898091370176 2847 625830 SGTC_1321 1326-2144 215 µM -0.282932774796285 0.408210793655535 no 2017 0.388614184988936 3027 3513030 SGTC_3242 9133940 49.47 µM -0.285714149150608 0.407304016493264 no 2018 0.387548533400074 3063 17248444 SGTC_1344 1488-0097 29.1 µM -0.285856702959442 0.407257554769446 no 2019 0.387493938288593 3006 747966 SGTC_2987 9018338 71.43 µM -0.287244762376226 0.406805221039159 no 2020 0.386962457166201 2952 5055682 SGTC_2452 5863136 48.41 µM -0.288058191600799 0.406540202592498 no 2021 0.386651097515504 2870 2184096 SGTC_1009 4106-0057 9.87 µM -0.288290453395371 0.406464538634954 no 2022 0.386562207092853 3058 2928005 SGTC_2990 9074105 71.4286 µM -0.289178488008588 0.406175275700049 no 2023 0.386222396507499 2976 6502001 SGTC_3029 9088683 49.47 µM -0.292496729186295 0.405094866575894 no 2024 0.384953430163972 3065 25236615 SGTC_1289 0976-0073 69.1 µM -0.293575877503294 0.404743654584944 no 2025 0.384541005441337 3030 3391136 SGTC_119 0121-0043 24.815 µM -0.295271056161491 0.404192108734621 no 2026 0.383893412588177 2942 1092378 SGTC_1097 itavastatin 7.23 µM -0.295739407029945 0.404039758918908 no 2027 0.38371455005827 2966 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1855 st056195 39.6 µM -0.2958746679587 0.403995762610025 no 2028 0.383662898710839 3106 4028379 SGTC_495 decylubiquinone 155 µM -0.295995255341485 0.403956540187926 no 2029 0.383616852412592 2994 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_116 0155-0182 31.788 µM -0.296480413667441 0.40379874666841 no 2030 0.383431611295245 2950 771486 SGTC_247 mechlorethamine 29.705 µM -0.299184350630553 0.402919602170327 no 2031 0.382399694570524 2921 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3132 9126706 49.47 µM -0.299726687123946 0.402743328527515 no 2032 0.382192820284048 3139 850858 SGTC_1842 st055362 61.2 µM -0.300644503737007 0.402445059010712 no 2033 0.381842795717638 2944 676032 SGTC_3087 9117406 49.47 µM -0.30215711460877 0.401953618874103 no 2034 0.381266147360841 3056 42546093 SGTC_2793 7325131 81.82 µM -0.302715551198047 0.401772224588644 no 2035 0.381053322694976 3003 4176441 SGTC_559 1550-0661 158 µM -0.303407647101353 0.401547443754324 no 2036 0.380789609318855 3010 5830875 SGTC_1871 st057448 67.3 µM -0.304223514324134 0.401282505962149 no 2037 0.380478805746459 3142 691747 SGTC_54 0159-0055 9 µM -0.304278187337484 0.401264753533288 no 2038 0.380457980887677 3174 3319099 SGTC_1247 0448-0043 5.84 µM -0.305275354153898 0.400941007412984 no 2039 0.380078222562676 3060 3089013 YGL099W LSG1 SGTC_1636 st007707 68.9 µM -0.306965685526746 0.400392369835682 no 2040 0.379434745526957 3152 403051 SGTC_1500 4488-1866 171 µM -0.307396803532938 0.400252471553926 no 2041 0.379270680451583 3076 2900003 SGTC_1583 clindamycin 39.6 µM -0.308259544133834 0.399972549698902 no 2042 0.378942423590823 2944 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2076 5212012 200 µM -0.308499681039633 0.399894644839002 no 2043 0.378851071454067 2920 604802 SGTC_944 3370-0224 231 µM -0.308724192041145 0.399821812915612 no 2044 0.37876566979636 2981 4580514 SGTC_2105 5350118 200 µM -0.308902271513438 0.399764045973304 no 2045 0.378697934420381 2969 2133313 SGTC_695 3505-6186 243 µM -0.309864198775249 0.399452045742237 no 2046 0.378332114469374 3054 1819379 SGTC_1374 2889-5571 141 µM -0.310966263116824 0.399094671100871 no 2047 0.377913134552596 3016 2853281 SGTC_1339 1486-1321 22.7 µM -0.311442703559024 0.398940198360066 no 2048 0.377732047101796 2976 3469382 SGTC_2886 9058944 51.95 µM -0.312083974392835 0.398732308878302 no 2049 0.377488352661441 2991 4949929 SGTC_3120 9124077 49.47 µM -0.312595540573679 0.398566488113641 no 2050 0.377293983283695 2974 18774327 YGL155W CDC43 SGTC_1641 st009299 47.1 µM -0.314520392061708 0.397942724646548 no 2051 0.376562915543613 3008 4046054 SGTC_1642 st009582 77.7 µM -0.315714607132414 0.397555860711542 no 2052 0.376109569241186 3109 6739311 SGTC_1997 st073024 93.8 µM -0.317799450009905 0.396880721068586 no 2053 0.375318533960698 3100 686268 SGTC_550 4123-0385 25.7 µM -0.318544674064337 0.39663946823653 no 2054 0.375035906501217 2961 5731123 SGTC_22 0964-0034 14.468 µM -0.323128446984739 0.395156427864561 no 2055 0.373298983647209 3021 138402 SGTC_1384 3089-0840 101 µM -0.323653598462618 0.394986616093703 no 2056 0.373100152227216 3098 1069836 SGTC_2337 9009472 200 µM -0.328562806586876 0.393400154684575 no 2057 0.371243082295358 3187 5742383 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.329322925564937 0.393154671803146 no 2058 0.370955808798745 3113 6708760 SGTC_2183 6420625 130.508 µM -0.330514510256303 0.392769931197401 no 2059 0.370505615246005 2996 2897619 SGTC_1346 1488-2224 62.4 µM -0.331281296742539 0.392522405422142 no 2060 0.370216008741333 3099 3722427 SGTC_112 phenothiazine 287.218 µM -0.331421853827574 0.392477037005603 no 2061 0.370162929907551 3142 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1825 st052143 62.6 µM -0.33165330221747 0.392402334265539 no 2062 0.370075533009306 3162 674173 SGTC_1341 1486-1360 280 µM -0.33341175991352 0.391834900654643 no 2063 0.369411743692686 2976 3976547 SGTC_2790 5423970 71.43 µM -0.339246997938453 0.389953592232854 no 2064 0.367211833494571 3181 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2903 5923464 63.88 µM -0.340521086458542 0.389543161014154 no 2065 0.366732072936718 3100 2876576 SGTC_956 1185-0240 191 µM -0.340710908576526 0.389482022793044 no 2066 0.366660612836925 3013 1416193 SGTC_3035 9091303 49.47 µM -0.340800989116126 0.389453010461059 no 2067 0.366626702892652 3024 25237002 SGTC_2687 chenodiol 100 µM -0.340897428802433 0.38942195071507 no 2068 0.366590400263197 3108 5702181 A cholesterol synthesis inhibitor. SGTC_2432 5630864 12.22 µM -0.341248847834356 0.389308777292828 no 2069 0.366458126286316 3145 5714970 SGTC_1081 sertraline 6 µM -0.344334912680795 0.388315323816253 no 2070 0.365297215628651 3125 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2755 lomerizine 42.69 µM -0.345512177546235 0.387936535553872 no 2071 0.364854678482852 3051 3949 A calcium channel blocker. SGTC_1236 0330-0013 258 µM -0.346182641738565 0.387720859444999 no 2072 0.364602729521724 3034 4617066 SGTC_2233 sulbentine 40.3845 µM -0.347043467424592 0.387443998307167 no 2073 0.364279331715546 3076 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_250 brefeldin a 552.239 µM -0.348813651441534 0.386874846825294 no 2074 0.363614606998687 2989 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1111 tnp00062 510.699 nM -0.349124624098772 0.386774887638068 no 2075 0.363497875463969 3174 676306 SGTC_888 0916-0002 6.97 µM -0.3508095397033 0.386233418378692 no 2076 0.362865619929586 3188 2802138 YIL048W NEO1 SGTC_574 1315-0397 40 µM -0.351116425904064 0.386134820373095 no 2077 0.362750502705045 3015 6794277 SGTC_321 4534-3890 65.3 µM -0.351504184453084 0.386010249792226 no 2078 0.362605066891447 3126 699746 SGTC_2711 st079103 59.1 µM -0.351942572961595 0.385869428080303 no 2079 0.362440665274969 3069 54693780 SGTC_271 rotenone 740 µM -0.352829796039582 0.385584475146011 no 2080 0.362108022264463 3144 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2791 5663188 71.43 µM -0.35291222768568 0.385558003381637 no 2081 0.362077121778559 3194 54690634 SGTC_743 1275-0778 158 µM -0.353145107639492 0.385483220138878 no 2082 0.361989828807412 3112 2849257 YMR203W TOM40 SGTC_657 3534-0529 86.7 µM -0.353785810518236 0.385277497317892 no 2083 0.361749704110662 3175 1049549 SGTC_12 0849-0099 9.267 µM -0.353825362180766 0.385264798760618 no 2084 0.361734882593314 3088 6071388 SGTC_417 st075190 100 µM -0.353850945704366 0.385256584915044 no 2085 0.361725295581158 3168 222757 SGTC_1372 2752-0194 270 µM -0.353894321987647 0.38524265864403 no 2086 0.361709041218081 3009 823334 SGTC_3044 9093193 49.47 µM -0.354099708922693 0.38517671968539 no 2087 0.361632080109577 3126 25236277 SGTC_1090 efavirenz 20.7 µM -0.355625417568802 0.384686998810738 no 2088 0.361060552993278 3075 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1978 st071761 42 µM -0.357267719432249 0.384160059496463 no 2089 0.360445696803567 3039 5147680 SGTC_2691 st077356 60.2 µM -0.35921005444864 0.383537129632534 no 2090 0.359718977773165 3199 2839272 SGTC_1764 st044502 93.5 µM -0.359917926285679 0.383310181473395 no 2091 0.359454255467551 3165 8407 SGTC_2459 5811157 9.22 µM -0.360673094957866 0.383068113792013 no 2092 0.359171919947872 3039 2870684 YBR192W RIM2 SGTC_2624 nerol 100 µM -0.36185353013285 0.382689819345976 no 2093 0.358730743780733 3016 637566 A natural product oil. SGTC_826 1683-5028 118 µM -0.362267495240418 0.382557182295067 no 2094 0.358576072941313 3113 722377 SGTC_637 1181-0519 7.26 µM -0.364350133084597 0.381890101172786 no 2095 0.357798283982485 3058 6252091 YGR060W ERG25 SGTC_1916 st067606 49.2 µM -0.364660145554203 0.381790832285891 no 2096 0.357682556054685 3100 19590279 SGTC_2857 9024691 58.44 µM -0.364786738197371 0.38175029837444 no 2097 0.357635302670758 3130 16478292 SGTC_1765 st044815 90.4 µM -0.364814891429458 0.381741284119894 no 2098 0.357624794177477 3129 645695 SGTC_2224 6650123 117.647 µM -0.365391601970632 0.381556643929003 no 2099 0.357409554595326 3069 2908370 SGTC_3263 9137018 49.47 µM -0.366760991785613 0.381118326832313 no 2100 0.356898653510016 3099 43844957 SGTC_1732 st034308 51.822 µM -0.367118638320284 0.381003875686007 no 2101 0.356765262570221 2940 830119 SGTC_781 4335-2806 94.4 µM -0.368845432465117 0.380451427642987 no 2102 0.356121469185722 3191 845254 SGTC_2151 5563267 85.4165 µM -0.369281666496456 0.380311903124935 no 2103 0.355958894682732 3080 5310824 SGTC_2175 5807670 165.306 µM -0.369932755299081 0.380103688708114 no 2104 0.355716297411402 3182 241186 SGTC_1917 st066507 28.5 µM -0.370191012325124 0.380021109231815 no 2105 0.355620086393775 3039 3156428 SGTC_939 1165-0479 45.3 µM -0.372400159393257 0.379314942998523 no 2106 0.354797467631994 3188 1377347 SGTC_2919 7978188 46.38 µM -0.372879678676777 0.379161715054773 no 2107 0.354618998561204 3230 2980291 SGTC_534 k292-0788 63.4 µM -0.372927637277949 0.379146391172004 no 2108 0.354601150925234 3229 4146317 SGTC_504 lovastatin 124 µM -0.373976983661471 0.378811148297901 no 2109 0.354210720076123 3094 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1322 1348-1070 12 µM -0.375922440368349 0.378189859401173 no 2110 0.3534872785462 3180 6758089 SGTC_1539 benzyladenosine 56 µM -0.376030605355437 0.378155325731163 no 2111 0.353447071590293 3058 92208 A nucleotide analog. SGTC_1365 1672-3266 55.4 µM -0.376490626482087 0.378008466366028 no 2112 0.353276091375027 3163 6415873 SGTC_988 1497-1057 103 µM -0.376772039142935 0.377918635518029 no 2113 0.353171510779882 3174 3533044 SGTC_639 0833-0042 114 µM -0.37688507002737 0.377882556340375 no 2114 0.353129508551167 3087 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1927 st060202 13.8 µM -0.379190603464149 0.377146868656238 no 2115 0.352273164410743 3197 688887 SGTC_2380 9035439 200 µM -0.379244524006429 0.377129668122771 no 2116 0.352253145647217 3215 6462575 SGTC_2722 naftopidil 47.16 µM -0.379245704992645 0.377129291393515 no 2117 0.352252707193972 3185 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3329 9141233 27.5565 µM -0.379547616579501 0.377032986801507 no 2118 0.352140625864228 3207 4909101 YNL103W MET4 SGTC_3173 9105693 49.47 µM -0.379884093081423 0.37692566561021 no 2119 0.352015727825614 3240 17096658 SGTC_576 1073-0113 22.7 µM -0.3807596948752 0.376646431769723 no 2120 0.351690784598189 3202 5439563 SGTC_2723 salbutamol 83.58 µM -0.38148376957129 0.376415569422051 no 2121 0.351422156169375 3169 9884233 β2-adrenoceptor agonist SGTC_1186 1319-0216 26 µM -0.38214285457125 0.376205466668979 no 2122 0.351177703121283 3225 4565136 SGTC_2391 6285546 200 µM -0.382832863055289 0.375985545447959 no 2123 0.350921846590178 3041 846083 SGTC_2198 6589944 200 µM -0.382943462605992 0.375950298626876 no 2124 0.350880842336053 3121 5290268 SGTC_172 1112-0046 2.638 µM -0.384418322677396 0.37548037648939 no 2125 0.350334211179102 3078 2802135 YIL048W NEO1 SGTC_3241 9133421 49.47 µM -0.385393244524042 0.375169846768074 no 2126 0.349973043436111 3137 17018221 SGTC_3026 9090633 49.47 µM -0.385512900314818 0.375131739867307 no 2127 0.349928725315278 3072 25236842 SGTC_740 k014-0057 261 µM -0.385701514223727 0.375071674279674 no 2128 0.349858870632631 3168 4012779 SGTC_2585 alliin 100 µM -0.385797999371619 0.375040948994165 no 2129 0.349823138544308 3279 87310 A garlic compound which reacts with lipids. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.386179622250345 0.374919430581972 no 2130 0.349681822239691 3184 7104 SGTC_1109 tnp00067 928.257 nM -0.387842598877278 0.374390041696099 no 2131 0.349066259426136 3117 676295 SGTC_2719 novobiocin 32.65 µM -0.387931471483909 0.374361756810529 no 2132 0.349033373747978 3204 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1692 fluoroquinolonic acid 71 µM -0.387936243439604 0.374360238091477 no 2133 0.349031608005362 3200 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_898 1000-0849 28.3 µM -0.38802920105748 0.374330653858397 no 2134 0.348997212020528 3163 6751807 SGTC_2460 5552655 174.22 µM -0.388216757215114 0.37427096541326 no 2135 0.348927816657506 3206 5401989 SGTC_82 0054-0107 293.755 µM -0.390081030935415 0.373677837304097 no 2136 0.348238314557342 3142 3104697 SGTC_1280 0880-0253 10.1 µM -0.391486074462476 0.373231013150035 no 2137 0.347718989986018 3094 6836607 SGTC_2405 ticlatone 3.52 µM -0.392427102507287 0.372931847883004 no 2138 0.347371331931662 2910 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3064 1327-0027 10 µM -0.394349425357796 0.3723209542896 no 2139 0.346661538685309 3074 16000455 YPR107C YTH1 SGTC_764 1951-2361 146 µM -0.395468786767802 0.371965381075788 no 2140 0.346248476375105 3112 5438930 SGTC_1993 st073995 70.8 µM -0.395928716228103 0.371819312795452 no 2141 0.346078807992919 3110 3098394 SGTC_411 enrofloxacin 100 µM -0.396681768917687 0.371580191807144 no 2142 0.345801072909373 3275 71188 A bacterial gyrase inhibitor. SGTC_2368 9071271 200 µM -0.398511026155416 0.370999544145067 no 2143 0.3451267661202 3125 27209959 SGTC_1395 3486-0190 4.35 µM -0.399474959009706 0.370693688060534 no 2144 0.344771635605435 3279 6748079 SGTC_3114 9122766 49.47 µM -0.403105638282064 0.369542407631834 no 2145 0.343435256478841 3165 17176985 SGTC_2524 avocatin b 10.57 µM -0.40439177888194 0.369134855062636 no 2146 0.342962322343876 3179 6710748 SGTC_3057 9095946 49.47 µM -0.407674944234325 0.368095152592243 no 2147 0.341756167421355 3117 24540043 SGTC_2761 levamisole 97.89 µM -0.408317697542323 0.367891720264421 no 2148 0.34152022402123 3269 26879 An alkaline phosphatase inhibitor. SGTC_1919 st067113 52.3 µM -0.408805535540932 0.367737343578378 no 2149 0.341341188622966 3236 1268243 SGTC_2282 7944268 200 µM -0.410688457538941 0.367141692136407 no 2150 0.340650495826465 3318 2970414 SGTC_3205 9113483 49.47 µM -0.410850508291615 0.367090443239721 no 2151 0.340591077348425 3269 17018033 SGTC_1457 k015-0032 57.3 µM -0.411238545144416 0.366967735382244 no 2152 0.340448813563211 3125 4302660 SGTC_1312 1218-2183 165 µM -0.411454402031474 0.36689948141728 no 2153 0.340369684982547 3202 6744073 SGTC_1343 1487-0095 224 µM -0.411697665746453 0.366822566453798 no 2154 0.340280518059709 3268 4560101 YGL055W OLE1 SGTC_10 0279-0212 42.575 µM -0.411936682441836 0.366746999517415 no 2155 0.340192916554808 3154 39851 YBR002C RER2 SGTC_634 1611-4317 11.2 µM -0.4128908445802 0.366445385421483 no 2156 0.339843294582202 3264 2843522 SGTC_462 ag-879 158 µM -0.413786059858626 0.366162479619951 no 2157 0.339515396995169 3214 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_973 1325-0077 65.9 µM -0.414278122227365 0.366007009109646 no 2158 0.339335217122161 3169 2835149 SGTC_2482 5981709 142.65 µM -0.414358020152211 0.365981766882747 no 2159 0.339305964137298 3156 877755 SGTC_2251 lansoprazole 556 µM -0.415272012783255 0.365693049625297 no 2160 0.338971393443767 3075 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_677 0929-0063 136 µM -0.41603003927601 0.365453657543076 no 2161 0.338694011089372 3194 1539583 SGTC_2642 cholecalciferol 100 µM -0.416261332199992 0.365380623435595 no 2162 0.33860939217418 3215 9821465 A vitamin D precursor, similar to steriods. SGTC_2808 7946468 45.46 µM -0.416262159728637 0.365380362140142 no 2163 0.338609089436021 3177 2970879 SGTC_2989 9073649 71.4286 µM -0.420473015630548 0.36405157921408 no 2164 0.337069969062452 3267 21367202 SGTC_1243 0416-0003 5.65 µM -0.421066543979477 0.36386441560218 no 2165 0.336853245457994 3146 2141977 SGTC_300 r073-0011 5.04 µM -0.421682676423326 0.363670158354098 no 2166 0.336628325382427 3252 2735780 SGTC_305 1682-2595 20.8 µM -0.42265241398021 0.363364485752418 no 2167 0.336274439607467 3208 226033 SGTC_678 1218-2179 85.9 µM -0.429401813827046 0.361239415337665 no 2168 0.333815417013022 3229 6820081 YOR116C RPO31 SGTC_2015 5119600 184 µM -0.430225515985695 0.360980361430116 no 2169 0.333515801341899 3297 2828786 SGTC_2092 5303694 80.6725 µM -0.43044744010667 0.360910577305523 no 2170 0.333435096203266 3162 1963699 SGTC_2113 5491891 107.031 µM -0.430666757124645 0.360841617534182 no 2171 0.333355346740008 3207 789979 SGTC_2890 9046729 58.44 µM -0.431197856744774 0.360674642817021 no 2172 0.333162256094823 3140 903329 SGTC_2705 st078069 42.8 µM -0.432613550164851 0.360229686638247 no 2173 0.332647771882106 3223 1530061 SGTC_2140 5586273 200 µM -0.432661388555519 0.36021465420831 no 2174 0.332630392191013 3249 854421 SGTC_3072 9116419 49.47 µM -0.434586228215899 0.359609984427035 no 2175 0.331931396562855 3202 17170162 SGTC_3000 9075062 71.4286 µM -0.434842200674892 0.359529599584887 no 2176 0.331838485465168 3163 17057871 SGTC_1172 0370-0043 85 µM -0.436581599947495 0.35898352850653 no 2177 0.331207404591623 3282 376585 SGTC_538 2922-0838 53.3 µM -0.43684854253955 0.358899749390949 no 2178 0.3311105960663 3329 777039 SGTC_2241 6772625 37.8075 µM -0.437153382905103 0.358804084476068 no 2179 0.33100005746523 3255 2285411 SGTC_2945 9067681 61.76 µM -0.437985947428406 0.358542854459952 no 2180 0.330698235126527 3266 16456930 SGTC_1783 st039459 87.517 µM -0.43812981410579 0.358497720763416 no 2181 0.330646091543168 3345 729761 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.438905089788632 0.358254536162325 no 2182 0.330365154287593 3173 4330530 SGTC_3277 9138724 49.47 µM -0.439245420505477 0.358147801074984 no 2183 0.330241858559329 3182 15943418 SGTC_338 4055-0136 114 µM -0.440374167908911 0.357793880822906 no 2184 0.32983306556533 3161 2900563 SGTC_1263 0774-1208 64.8 µM -0.440507939943289 0.357751944518076 no 2185 0.329784631450349 3347 906585 SGTC_1998 st075797 76.8 µM -0.440593546610813 0.35772510851456 no 2186 0.329753637806088 3294 24208315 SGTC_742 0kpi-0133 140 µM -0.444276843822416 0.356571135093637 no 2187 0.328421220396447 3315 2728852 SGTC_2253 7938677 135.83 µM -0.444338397721988 0.356551861431972 no 2188 0.328398971997635 3325 2301972 SGTC_2115 tiliquinol 12.7705 µM -0.444512640430999 0.356497304811138 no 2189 0.328335996000784 3230 71208 A bioactive hydroxyquinoline. SGTC_1516 st013856 110 µM -0.445242084460146 0.356268942630069 no 2190 0.328072408296741 3263 5281404 A mutagen and neurotoxin. SGTC_1644 st010134 20.9 µM -0.44570379442315 0.356124424797218 no 2191 0.327905611664716 3298 3818134 SGTC_1106 tegaserod maleate 11.7 µM -0.446945147816777 0.355735976680051 no 2192 0.327457332506893 3223 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1671 st016596 74.5 µM -0.447499855437823 0.355562444254117 no 2193 0.327257096112694 3246 2829167 SGTC_2537 larixol 68.93 µM -0.448367616162303 0.355291037650533 no 2194 0.326943954620699 3288 6708759 SGTC_2014 4013930 200 µM -0.449659147605105 0.354887225623695 no 2195 0.326478116188985 3309 64556 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.451400948651538 0.354342889829069 no 2196 0.325850299865636 3277 616764 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.45166283097234 0.354261073844179 no 2197 0.325755949401946 3317 1377 SGTC_1490 4089-0339 670 nM -0.454117852899594 0.353494415526101 no 2198 0.324872002134962 3305 742542 SGTC_1447 4239-0816 81.9 µM -0.454173557285687 0.353477026948203 no 2199 0.324851956805246 3215 1341554 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.45431127970264 0.353434037086541 no 2200 0.324802399307462 3323 5377381 SGTC_1990 st072050 59.8 µM -0.454337659927638 0.353425802749207 no 2201 0.324792907103927 3192 17233948 SGTC_492 tmb-8 126 µM -0.458160627911132 0.352233226615863 no 2202 0.323418522013808 3232 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1367 1812-0510 76.9 µM -0.458415643738272 0.352153725861461 no 2203 0.323326927345166 3250 1142582 YDR527W RBA50 SGTC_1078 idebenone 36.1 µM -0.458418830035862 0.352152732579418 no 2204 0.323325782982455 3275 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_796 1234-0020 70.7 µM -0.458595416767122 0.352097685805187 no 2205 0.323262364253603 3250 46495034 SGTC_371 0195-0006 7.36 µM -0.459787067779316 0.351726297606746 no 2206 0.322834533299135 3198 3928593 SGTC_1218 1348-1416 30.7 µM -0.460364263913496 0.351546460338474 no 2207 0.322627390423416 3214 6787668 SGTC_602 3130-1533 38.1 µM -0.460471068455214 0.351513186838934 no 2208 0.322589066677425 3319 720941 SGTC_2049 5262831 67.185 µM -0.463730846333942 0.350498195808304 no 2209 0.321420297127289 3267 763417 SGTC_2902 5787006 60.46 µM -0.466023162824684 0.349785079625282 no 2210 0.320599460470098 3165 591003 SGTC_827 3253-0474 693 µM -0.466118790164312 0.349755342429809 no 2211 0.320565237086291 3327 5402065 SGTC_2617 dihydrotanshinone i 20.83 µM -0.466364378428424 0.349678976169291 no 2212 0.320477352250964 3208 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2940 9060638 45.86 µM -0.466947951931685 0.34949753698878 no 2213 0.320268558300892 3292 4027022 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.467154213173858 0.349433416405758 no 2214 0.320194774689448 3297 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2005 4024620 188 µM -0.468274367424593 0.349085268299651 no 2215 0.319794198182859 3269 236743 SGTC_292 k038-0015 474 µM -0.471455921461302 0.34809712283003 no 2216 0.318657594853189 3332 46368540 SGTC_531 3788-1495 174 µM -0.471574092264885 0.348060440465571 no 2217 0.318615411345511 3167 2896655 SGTC_2094 5332512 191.667 µM -0.473612564421561 0.347427885718882 no 2218 0.317888107038717 3360 755774 SGTC_42 0133-0086 60.653 µM -0.475666517292029 0.346790956650245 no 2219 0.317155989239633 3203 162923 Model of phenazepam hydroxylation. SGTC_626 0214-0009 33 µM -0.475791423571174 0.346752237258028 no 2220 0.317111490265804 3356 3437874 SGTC_1805 st050013 60.3 µM -0.475998712720393 0.346687983733564 no 2221 0.317037647497345 3254 4037144 SGTC_2010 4012422 159 µM -0.477187420280823 0.346319604639141 no 2222 0.316614334074093 3256 952393 SGTC_1742 st038235 28.8875 µM -0.478897258837956 0.345789982586864 no 2223 0.316005860570532 3313 564103 YBR002C RER2 SGTC_182 3448-4371 550.524 µM -0.47962057963978 0.345566024880845 no 2224 0.315748605077542 3367 3491403 SGTC_1936 st074407 74.3 µM -0.481429062243303 0.345006311326974 no 2225 0.315105792794536 3233 809813 SGTC_348 k064-0012 10.7 µM -0.481698453192057 0.34492296556433 no 2226 0.315010087530389 3250 5066323 SGTC_69 0096-0274 206.684 µM -0.483918485794884 0.344236405582644 no 2227 0.314221860261226 3495 6741392 SGTC_2654 protoveratrine a 100 µM -0.484259078914385 0.344131120211238 no 2228 0.314101006762778 3273 5702278 A heart drug and vasodilator. SGTC_236 1509-0011 5.31 µM -0.484472115445846 0.344065271732705 no 2229 0.314025424615386 3417 3107280 SGTC_184 1494-0393 24.714 µM -0.485699218277142 0.343686072771406 no 2230 0.313590218992798 3202 3090647 SGTC_2074 5212007 75.395 µM -0.486560867141693 0.343419900223782 no 2231 0.313284780607977 3346 758611 SGTC_3237 9133362 49.47 µM -0.487279553940091 0.343197949562696 no 2232 0.313030117516871 3331 43845137 SGTC_1976 st070609 63.5 µM -0.488752079446447 0.342743361324413 no 2233 0.312508614053039 3281 682556 SGTC_2796 7949634 45.45 µM -0.491671547972773 0.341842756003365 no 2234 0.311475777477348 3277 2971588 SGTC_2713 st079149 53.4 µM -0.492469599079182 0.34159672739971 no 2235 0.311193704066127 3324 3103253 SGTC_1486 3970-0793 4.53 µM -0.494776841807096 0.340885813734968 no 2236 0.3103788265431 3368 2844330 SGTC_2859 9028643 45.46 µM -0.494910401156343 0.340844678344314 no 2237 0.310331684166875 3312 17151580 SGTC_2397 5161689 200 µM -0.495309885290471 0.340721651186023 no 2238 0.310190697054457 3425 2259942 SGTC_2374 9071832 200 µM -0.49546669688323 0.340673363322693 no 2239 0.310135362269963 3375 17381698 SGTC_907 3448-6986 75.5 µM -0.495912880755093 0.340535981734964 no 2240 0.309977938960918 3420 590582 SGTC_255 tunicamycin 200.472 nM -0.496555670066398 0.340338101833664 no 2241 0.309751210242183 3308 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1084 voriconazole 435 nM -0.497753407247305 0.339969500927381 no 2242 0.309328929872231 3387 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_91 0417-1751 58.384 µM -0.498477034209695 0.339746880448879 no 2243 0.309073926166301 3381 6795624 SGTC_2367 9070478 135.38 µM -0.499858345090001 0.339322081774094 no 2244 0.308587412274184 3332 572802 SGTC_291 SEC14.278 35.5 µM -0.500834412793515 0.339022031788949 no 2245 0.308243832219644 3381 1068044 SGTC_2480 5767542 37.17 µM -0.501180918468914 0.338915538082854 no 2246 0.308121901096581 3276 2867358 SGTC_2569 tetrandrine 100 µM -0.504063297083892 0.338030178649181 no 2247 0.307108448840624 3271 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3084 9116877 49.47 µM -0.50714781060069 0.337083722343785 no 2248 0.306025555329508 3328 27241325 SGTC_1965 Pectolinarigenin 58.4 µM -0.507380176869325 0.337012464423433 no 2249 0.305944045961678 3307 5320438 An anti-inflammatory. SGTC_3231 9132313 49.47 µM -0.508042854057777 0.336809278596958 no 2250 0.305711645052264 3331 4905967 SGTC_903 1134-0042 114 µM -0.512952918483846 0.335305273115446 no 2251 0.303992127529885 3313 701009 SGTC_1881 5652484 16 µM -0.514199735732201 0.334923778308758 no 2252 0.303556176256366 3380 2255129 SGTC_2742 clothiapine 36.27 µM -0.515320426019693 0.334581020477503 no 2253 0.303164563862109 3355 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2487 5918373 44.05 µM -0.518339589380748 0.333658310027974 no 2254 0.302110677824826 3470 2876279 SGTC_490 phenamil 164 µM -0.519346503096811 0.333350802386191 no 2255 0.301759565007921 3330 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1309 pyrazolanthrone 13.4 µM -0.520062106943965 0.33313232772722 no 2256 0.301510144091514 3402 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_597 k018-0003 82.8 µM -0.5203111548939 0.333056306385148 no 2257 0.301423361169844 3419 6786234 SGTC_848 0368-0089 85.6 µM -0.520672574717097 0.332945995976355 no 2258 0.30129744129384 3391 762535 SGTC_1463 k081-0032 34.1 µM -0.522874902646136 0.332274127262147 no 2259 0.300530655386862 3325 977755 SGTC_2971 9092186 9.93 µM -0.52402088207833 0.33192473389134 no 2260 0.300132007902435 3268 25236400 SGTC_2298 7976326 193.81 µM -0.524554143375925 0.331762199648479 no 2261 0.299946585903328 3336 2235818 SGTC_1242 0402-0103 60.1 µM -0.525464056656026 0.331484937684819 no 2262 0.299630316794105 3346 432868 SGTC_2416 tofa 880 nM -0.528034252643387 0.330702265890858 no 2263 0.29873778122463 3269 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1717 st033143 58.0435 µM -0.528815264459195 0.330464579840577 no 2264 0.298466803840352 3461 674616 SGTC_1991 st073000 8.92 µM -0.529244719442287 0.33033391253431 no 2265 0.298317849172262 3493 4301969 YIL048W NEO1 SGTC_536 3852-0578 10.6 µM -0.529861210253773 0.330146373289801 no 2266 0.29810408108943 3452 2869208 SGTC_761 k216-0224 480 µM -0.529951430231304 0.330118931549642 no 2267 0.298072803182627 3492 1340404 SGTC_1054 3429-0080 167 µM -0.530978118383685 0.329806713574206 no 2268 0.297716971253006 3444 1162877 SGTC_1540 guanosine 70.6 µM -0.531210062809616 0.329736195206096 no 2269 0.297636610267926 3380 6802 Guanosine is a purine nucleoside SGTC_2419 paclitaxel 166.5 µM -0.53200166097645 0.329495570164059 no 2270 0.297362422556557 3358 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2647 atorvastatin 60.16 µM -0.532587215748433 0.32931762230855 no 2271 0.29715967685379 3388 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_935 2996-0153 430 µM -0.532602807181279 0.329312884659902 no 2272 0.297154279254221 3447 23738523 SGTC_221 trifluoperazine 10.304 µM -0.533290908393604 0.329103823946276 no 2273 0.296916110085504 3417 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1159 4092-0538 61.2 µM -0.53401423093742 0.328884119804138 no 2274 0.296665844133604 3414 717301 SGTC_3106 9121286 49.47 µM -0.534342002008735 0.328784581101313 no 2275 0.296552468812016 3479 15943471 SGTC_2426 5582046 32.21 µM -0.535349249784487 0.328478772484343 no 2276 0.296204188228049 3462 2251934 SGTC_1767 st044992 70.3 µM -0.536075017155461 0.328258494792846 no 2277 0.295953352753583 3377 9600693 SGTC_3028 9087778 49.47 µM -0.53697656773998 0.327984948273304 no 2278 0.295641900006405 3326 17217395 SGTC_233 rapamycin 362 pM -0.538398595160316 0.327553667346215 no 2279 0.295150948021601 3431 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1307 1187-1599 12.2 µM -0.539548259511918 0.327205158415554 no 2280 0.294754303463257 3317 1538471 SGTC_1459 k035-0031 35.7 µM -0.544644020912382 0.325662247201385 no 2281 0.292999186173581 3365 3877128 YMR208W ERG12 SGTC_653 0203-0016 55.2 µM -0.544673895463168 0.325653210454916 no 2282 0.292988910885983 3391 295302 SGTC_3168 9103419 49.47 µM -0.545248657483005 0.325479370768075 no 2283 0.292791255283014 3397 16649256 SGTC_2448 5185112 27.17 µM -0.545643675638748 0.325359917530116 no 2284 0.292655447920479 3421 5718189 SGTC_1546 5-methoxyflavanone 78.7 µM -0.546666756094064 0.325050622077948 no 2285 0.292303848651884 3455 147795 SGTC_684 1140-0066 328 µM -0.547250355957035 0.324874243409253 no 2286 0.292103372517794 3432 6813534 SGTC_2202 7226349 200 µM -0.549250306382754 0.324270105629076 no 2287 0.291416842596517 3347 844334 SGTC_3281 9140613 49.47 µM -0.549471071399038 0.324203446039085 no 2288 0.291341105980447 3384 16013766 SGTC_2839 9003951 25.97 µM -0.551761544066693 0.323512174870614 no 2289 0.290555868939145 3436 2990634 SGTC_1037 k284-1091 78.7 µM -0.552465622347655 0.323299804234447 no 2290 0.290314690687717 3452 3334711 SGTC_2213 7173844 200 µM -0.553260848828895 0.323060009856527 no 2291 0.290042402906542 3380 892728 SGTC_551 k048-0028 34.9 µM -0.554119983614903 0.322801027042383 no 2292 0.289748367342249 3479 6836383 SGTC_380 3970-0968 6 µM -0.55472995378382 0.322617206070705 no 2293 0.289539692348943 3368 2891601 SGTC_2269 7935389 174.42 µM -0.5547788172478 0.322602482422923 no 2294 0.289522978875086 3414 97605 SGTC_861 0443-0273 110 µM -0.555981752934447 0.322240098930353 no 2295 0.289111664408149 3428 6149169 SGTC_1897 st060201 15 µM -0.556027987655597 0.322226174122884 no 2296 0.289095861060175 3403 611878 SGTC_2586 curcumin 80 µM -0.556333611755054 0.322134133629212 no 2297 0.288991406845659 3437 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_564 3555-0129 330 µM -0.557769073633035 0.321701981840999 no 2298 0.288501041728358 3413 563260 SGTC_2997 9067075 71.4286 µM -0.558418914215444 0.321506423870056 no 2299 0.288279180059006 3421 27209819 SGTC_2394 5221648 200 µM -0.559058426079205 0.321314022426429 no 2300 0.288060923297066 3462 788586 SGTC_2868 9035608 32.47 µM -0.559169324742506 0.321280662694279 no 2301 0.28802308301703 3443 6462614 SGTC_1529 apigenin 74 µM -0.560500879970764 0.320880226556317 no 2302 0.2875689198066 3541 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1863 st057641 20.1 µM -0.56170232408079 0.320519097213136 no 2303 0.287159425312021 3474 3921635 SGTC_2145 5634607 200 µM -0.561828801244956 0.320481090659246 no 2304 0.287116333501666 3391 308662 SGTC_2571 chrysanthemic acid 100 µM -0.562840650104321 0.320177096549501 no 2305 0.286771698546453 3393 2743 An insecticide. SGTC_2646 retinol 96.75 µM -0.563251443380716 0.320053714582772 no 2306 0.286631838654822 3490 445354 A vitamin A analog and teratogen. SGTC_2316 5844804 197.44 µM -0.566258382167314 0.319151185649529 no 2307 0.285609073698558 3454 776813 SGTC_2222 6885208 172.143 µM -0.566568432341271 0.319058185289175 no 2308 0.285503713649193 3434 609514 SGTC_2612 dictamnine 15.46 µM -0.567829316355695 0.318680097208163 no 2309 0.285075435659649 3403 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2427 5545055 42.75 µM -0.568536604430626 0.318468092720047 no 2310 0.284835328923519 3443 5372858 SGTC_673 1082-0474 110 µM -0.569883035853366 0.318064673916353 no 2311 0.284378515754397 3444 3098046 SGTC_2117 5521686 200 µM -0.57219759943429 0.317371687059524 no 2312 0.283594056819704 3426 803312 SGTC_1968 st069590 43.6 µM -0.57462426157276 0.316645824408301 no 2313 0.282772720032642 3449 6384066 SGTC_3079 9117512 49.47 µM -0.575774225356372 0.316302093681642 no 2314 0.282383898647724 3499 7185044 SGTC_859 0439-0102 54.6 µM -0.576368844447374 0.316124420858152 no 2315 0.282182949221085 3517 610143 SGTC_1261 0712-0010 12.7 µM -0.576578127509432 0.316061896952708 no 2316 0.282112239127783 3525 2840123 SGTC_1491 4138-0063 26.5 µM -0.577600111717612 0.315756651877308 no 2317 0.28176706575157 3470 23883227 SGTC_1715 st032160 10.2275 µM -0.57764853689874 0.315742191415175 no 2318 0.281750715284133 3436 5289825 SGTC_2673 kobusone 100 µM -0.57799763405197 0.315637954283546 no 2319 0.28163285829136 3526 6710676 An epoxy ketone and protein crosslinker. SGTC_100 0086-0128 49.5915 µM -0.579324793467041 0.315241810851759 no 2320 0.281185019567207 3456 93297 SGTC_3309 9129340 25.759 µM -0.579463713163535 0.315200357020626 no 2321 0.281138162180708 3440 17158987 SGTC_619 1652-1634 108 µM -0.579499841923249 0.315189576529588 no 2322 0.281125976627124 3423 5400454 SGTC_883 0850-0245 24.6 µM -0.580244488117372 0.314967415986645 no 2323 0.280874878254304 3534 6823229 YPR165W RHO1 SGTC_1086 cerivastatin 2.18 µM -0.580333781040296 0.314940780493007 no 2324 0.280844775521427 3465 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2016 5121758 140 µM -0.581813117500365 0.314499644264331 no 2325 0.280346283712359 3487 2795203 SGTC_1721 st082152 9.2685 µM -0.58186218141418 0.314485018000372 no 2326 0.280329757995695 3469 5296051 SGTC_2257 7960413 200 µM -0.582411225166524 0.314321364439296 no 2327 0.280144861160713 3463 2974689 YIL048W NEO1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.583631559024711 0.313957750046249 no 2328 0.279734111385952 3468 75037 A free radical scavenger. SGTC_3127 9126946 49.47 µM -0.585824928697173 0.313304661026987 no 2329 0.278996584842417 3420 27243249 SGTC_188 3229-0966 278.469 µM -0.586043711412846 0.313239549213294 no 2330 0.278923070463163 3536 5722370 SGTC_991 3996-0057 64.7 µM -0.586318889405678 0.31315766189602 no 2331 0.278830619780568 3469 715343 SGTC_2889 9059656 51.95 µM -0.587314210496763 0.312861551741904 no 2332 0.27849634946363 3495 3949838 SGTC_2451 5856223 45.7 µM -0.590004506583424 0.312061787346121 no 2333 0.277593814089225 3449 2179896 SGTC_585 0kpi-0023 191 µM -0.590080029098358 0.312039348958852 no 2334 0.277568498576714 3459 64601 SGTC_2177 5811945 192 µM -0.590280432709062 0.311979810707172 no 2335 0.277501327785414 3517 5343475 SGTC_2769 toremifene 3.73 µM -0.591511129371542 0.311614288681145 no 2336 0.277089000179245 3550 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2862 9027634 71.43 µM -0.592513517413651 0.311316712353301 no 2337 0.276753385867702 3455 5012562 SGTC_3019 9081971 49.47 µM -0.594629843770488 0.31068884903859 no 2338 0.276045463321335 3556 16451803 SGTC_1421 4029-0249 71.4 µM -0.595236244212618 0.310509046028319 no 2339 0.275842783123457 3571 2894095 SGTC_1865 st057639 52.2 µM -0.595783950377944 0.310346685284188 no 2340 0.275659783468159 3512 688818 SGTC_3315 9136395 68.55 µM -0.596624484023603 0.310097591315161 no 2341 0.275379060390098 3581 16876844 SGTC_2353 9059630 146.67 µM -0.600802494693433 0.308860723362298 no 2342 0.273985771171658 3503 4779114 SGTC_1634 st006576 41 µM -0.601372865622222 0.308692037045774 no 2343 0.2737958336547 3540 3915356 SGTC_3349 9149703 23.001 µM -0.601649311474309 0.30861029313296 no 2344 0.27370379868241 3515 4910494 SGTC_2798 7813637 45.45 µM -0.602367099064505 0.308398090554433 no 2345 0.273464902708063 3523 956368 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.6026399915319 0.308317430987951 no 2346 0.273374105001331 3521 17037758 SGTC_2495 cafestol 54.53 µM -0.604250682730189 0.307841543211668 no 2347 0.272838494648968 3551 16667697 An anti-infammatory. SGTC_2858 9025781 8.96 µM -0.604973155181871 0.30762818955672 no 2348 0.272598416868331 3568 4894980 YPL153C RAD53 SGTC_1390 3413-2614 145 µM -0.605041188319241 0.307608102011285 no 2349 0.272575814842779 3522 3421432 SGTC_1040 k898-0338 155 µM -0.605298771636001 0.30753205288022 no 2350 0.272490248728742 3581 20969351 SGTC_895 0964-0006 13.7 µM -0.607469051365733 0.30689162623703 no 2351 0.271769837669598 3533 6738897 SGTC_3256 9138902 49.47 µM -0.608655364894596 0.306541806414144 no 2352 0.2713764492345 3527 17228773 SGTC_3261 9137475 49.47 µM -0.611297639919774 0.305763286634969 no 2353 0.270501276572936 3425 17027690 SGTC_3215 9129942 49.47 µM -0.611572811819337 0.305682260365562 no 2354 0.270410215452081 3497 17682944 SGTC_2089 5281248 129.67 µM -0.614397370529759 0.304851100088667 no 2355 0.269476386467953 3554 2737878 SGTC_310 1273-0058 1.06 µM -0.616696772941128 0.304175215884754 no 2356 0.268717375082244 3566 2734232 SGTC_1588 farnesol 29.9 µM -0.617475109693145 0.303946583636895 no 2357 0.268460696873213 3567 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_130 0136-0219 337.655 µM -0.620589938404397 0.303032387385167 no 2358 0.267434730730498 3525 234244 SGTC_1315 1237-0019 3.69 µM -0.62075413290305 0.302984230767284 no 2359 0.26738070306331 3547 825140 SGTC_620 0109-0052 432 µM -0.621082970250563 0.302887796333986 no 2360 0.267272516758634 3566 493037 SGTC_84 0443-0269 128.823 µM -0.621975215225986 0.302626206926393 no 2361 0.2669790826914 3526 6150058 SGTC_1164 k060-0068 93.7 µM -0.623963848353897 0.302043541780172 no 2362 0.266325663638404 3587 5963676 SGTC_1431 4049-0260 9.09 µM -0.623990477204476 0.302035743004515 no 2363 0.266316919505474 3546 3854841 SGTC_2519 cryptotanshinone 88.04 µM -0.624441516088011 0.301903661254941 no 2364 0.266168833650249 3560 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_713 1488-1073 324 µM -0.625601517440567 0.301564086948857 no 2365 0.265788171615137 3537 3312542 SGTC_3169 9102970 49.47 µM -0.625613890408351 0.301560465860474 no 2366 0.265784112832674 3616 17027839 SGTC_2677 mitomycin C 100 µM -0.626303498091563 0.301358675340594 no 2367 0.265557946170187 3562 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_685 1278-0033 54.9 µM -0.627130484100248 0.301116765867344 no 2368 0.265286853116697 3607 3590572 SGTC_1779 st039427 55 µM -0.627492330091271 0.301010946412555 no 2369 0.265168281119793 3611 1124498 SGTC_838 0109-0203 71.4 µM -0.627589249812778 0.300982605730926 no 2370 0.265136526419105 3572 759422 SGTC_3356 9151811 4.48 µM -0.628072309306171 0.300841370324789 no 2371 0.264978285996613 3518 1859254 YPR165W RHO1 SGTC_2462 5162487 171.77 µM -0.62859134859803 0.300689648585669 no 2372 0.264808312826195 3540 2259986 SGTC_2671 danthron 100 µM -0.629057937817634 0.300553288148367 no 2373 0.264655563146591 3516 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1036 k216-0215 33.5 µM -0.629678325902443 0.300372023338952 no 2374 0.264452532982443 3561 622330 SGTC_975 1335-0046 28.5 µM -0.630372932975909 0.300169131883209 no 2375 0.264225307774404 3512 16486740 SGTC_1521 st012942 49.4 µM -0.630390837509438 0.300163902872637 no 2376 0.264219452020468 3570 24207259 SGTC_2640 pentamidine 10.38 µM -0.630859611150434 0.300027012411785 no 2377 0.264066161126408 3570 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1470 k295-0292 231 µM -0.633622278064273 0.2992208376144 no 2378 0.263163679135639 3585 5045612 SGTC_1587 estradiol valerate 56.1 µM -0.634027230581903 0.299102750923839 no 2379 0.263031525602974 3598 13791 A steroid. SGTC_651 3253-0966 34.4 µM -0.634927007853457 0.298840445991248 no 2380 0.262738010793584 3553 781462 SGTC_2193 5925765 200 µM -0.634988470945625 0.298822531957857 no 2381 0.262717967138107 3582 877370 SGTC_756 0508-1999 28.3 µM -0.635137576839518 0.298779075580658 no 2382 0.262669345644187 3483 6753853 SGTC_3288 9119690 36.221 µM -0.635431221973763 0.298693502160215 no 2383 0.262573605246047 3530 17595618 YKL019W RAM2 SGTC_2992 9074591 71.4286 µM -0.636338333694948 0.298429224057158 no 2384 0.262277962336269 3581 17741321 SGTC_1677 st019204 53.9 µM -0.636443433216023 0.298398611222165 no 2385 0.262243719666883 3539 3945625 SGTC_2477 5967686 25.23 µM -0.637091237190561 0.298209953853263 no 2386 0.262032708030863 3568 776118 SGTC_824 1304-0008 100 µM -0.637495103358705 0.298092365015755 no 2387 0.261901199236532 3577 768245 SGTC_2343 7990716 14.84 µM -0.637761912789052 0.298014692924557 no 2388 0.261814338069098 3556 6456862 SGTC_37 0566-0070 1.56 µM -0.639029681788437 0.297645753102716 no 2389 0.261401811434925 3584 1626686 SGTC_2284 7945075 39.21 µM -0.642138176029737 0.296742017899381 no 2390 0.260391735221781 3609 1245402 SGTC_3164 9100705 49.47 µM -0.642590049136956 0.29661074909806 no 2391 0.260245070813593 3586 17174235 SGTC_1216 1165-0504 9.65 µM -0.642788603036396 0.296553077750867 no 2392 0.260180639659337 3596 6304004 SGTC_2592 piperlongumine 83.33 µM -0.643815517200745 0.29625488549128 no 2393 0.259847535144809 3535 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1423 4048-0112 5.59 µM -0.644653201106737 0.296011743238667 no 2394 0.259575975086603 3587 X1423 SGTC_3147 9097027 49.47 µM -0.644738352167844 0.295987032815677 no 2395 0.259548379054084 3589 25236841 SGTC_2390 9097792 176.6 µM -0.645189142826283 0.295856231343134 no 2396 0.25940231059585 3519 4497149 SGTC_1733 st037357 54.9 µM -0.645852020095221 0.295663939032066 no 2397 0.25918759745602 3557 1272339 YGL099W LSG1 SGTC_2310 7668677 200 µM -0.646958274464826 0.295343156622364 no 2398 0.258829474358137 3633 2197143 SGTC_2440 5628896 157.78 µM -0.649221026598968 0.294687521926971 no 2399 0.258097761361945 3603 5522048 SGTC_922 1866-0035 480 µM -0.650103332844677 0.294432054837216 no 2400 0.257812738274016 3595 3156169 SGTC_1464 k208-0027 110 µM -0.652867320346384 0.293632419479792 no 2401 0.256920909299794 3628 X1464 SGTC_1400 3771-8998 51.5 µM -0.654705265321583 0.293101249991846 no 2402 0.256328767286758 3555 670767 SGTC_452 diindolylmethane 8 µM -0.656467608667817 0.29259234843514 no 2403 0.255761651068053 3581 3071 Inhibits expression of several cancer promoting factors. SGTC_1324 1418-0026 34.4 µM -0.657053294814845 0.292423314214612 no 2404 0.255573324339166 3629 1372513 SGTC_525 k781-2675 26.7 µM -0.657634270597908 0.292255684313418 no 2405 0.255386583809957 3636 3651118 YDL195W SEC31 SGTC_145 3737-0113 38.366 µM -0.657681444681824 0.292242075059501 no 2406 0.255371423979295 3639 6849351 SGTC_2132 5317594 122.667 µM -0.65790373793447 0.292177949635524 no 2407 0.255299994305165 3593 794577 SGTC_573 3702-0553 84.7 µM -0.660619521129942 0.291395050809476 no 2408 0.254428173411605 3599 1222756 SGTC_2707 st078556 66.6 µM -0.661888484869698 0.291029573105739 no 2409 0.254021346061499 3582 17250899 SGTC_2449 5812982 45.77 µM -0.663142396152371 0.290668641189862 no 2410 0.253619680001531 3588 776185 SGTC_1042 0350-0096 82 µM -0.663383751805935 0.290599192242182 no 2411 0.253542404722464 3622 3122515 SGTC_213 1246-0773 967 nM -0.665459684214058 0.290002173309333 no 2412 0.252878260756711 3578 6251622 SGTC_2502 avocadyne acetate 18.59 µM -0.666313535582993 0.289756780573676 no 2413 0.252605357844543 3602 3952079 SGTC_2967 9089538 49.85 µM -0.666900017865305 0.289588284879417 no 2414 0.252417999770585 3630 728216 SGTC_875 0709-0210 25.7 µM -0.668140447414347 0.289232062497217 no 2415 0.252021972604593 3641 6251364 SGTC_2710 st078562 53.7235 µM -0.669010942057746 0.288982199834952 no 2416 0.25174424901827 3600 17250908 SGTC_225 nsc-122657 1.016 µM -0.669381575568152 0.288875845779061 no 2417 0.251626050758864 3581 275685 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.672354698293569 0.288023369352279 no 2418 0.250678957716633 3643 688669 SGTC_2208 7283366 200 µM -0.672441193754469 0.287998586499191 no 2419 0.250651432738033 3640 898663 SGTC_735 3076-0345 636 µM -0.674725731983291 0.287344380718721 no 2420 0.249925016484761 3661 2888990 SGTC_1010 4112-3296 15.2 µM -0.676135166141953 0.286941122806883 no 2421 0.249477415635886 3669 704384 SGTC_1658 st012944 20 µM -0.67677749063925 0.28675743417923 no 2422 0.249273570921731 3586 24207260 SGTC_1939 st074455 53.6 µM -0.680039653209278 0.285825399353542 no 2423 0.248239676698 3666 1644229 SGTC_2395 5646831 180.19 µM -0.68025293049982 0.28576451394968 no 2424 0.248172161337888 3653 6808628 SGTC_3198 9112019 49.47 µM -0.680620273430534 0.285659661072107 no 2425 0.248055897705319 3675 45595555 SGTC_323 4013-0906 34.3 µM -0.682850438166733 0.285023485127747 no 2426 0.247350677189244 3665 2910086 SGTC_1240 0356-0016 42.1 µM -0.686563789727066 0.283965717252644 no 2427 0.24617882671652 3640 4305613 SGTC_2543 pimpinellin 60.67 µM -0.687072789094108 0.283820872600493 no 2428 0.246018430268163 3583 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_62 0180-0423 3.232 µM -0.687805609313496 0.283612397960254 no 2429 0.24578760164742 3631 30102 YGL099W LSG1 SGTC_1862 st057513 3.81 µM -0.689802374554209 0.283044725459195 no 2430 0.245159237607221 3644 5393163 SGTC_2932 9016711 44.54 µM -0.690945538431952 0.282719974145191 no 2431 0.244799883466371 3635 7117328 SGTC_2848 9016370 25.97 µM -0.692758068828158 0.282205435688353 no 2432 0.244230695290222 3669 7894410 SGTC_90 0870-0863 4.608 µM -0.695302549888343 0.281483873542774 no 2433 0.243432858307416 3660 1738164 SGTC_784 4579-0127 173 µM -0.696576672733342 0.281122893437051 no 2434 0.243033879334218 3767 1948547 SGTC_269 exalamide 29 µM -0.698021514929893 0.280713816460632 no 2435 0.242581869563143 3646 3316 A derivative of salicylamide. SGTC_1057 3448-5381 134 µM -0.699329058947288 0.280343860956783 no 2436 0.242173205395506 3702 5497911 SGTC_693 4161-2696 114 µM -0.699597742914153 0.280267868974591 no 2437 0.242089276262742 3689 805759 SGTC_2925 9010536 32.5 µM -0.700205434901234 0.280096032045803 no 2438 0.241899508979715 3670 2994177 SGTC_1000 4048-0884 8.67 µM -0.701590121200708 0.279704675442377 no 2439 0.241467407065521 3664 13040088 SGTC_1785 bathophenanthroline 24 µM -0.701989270137677 0.279591912485281 no 2440 0.241342927484101 3636 72812 An iron chelator. SGTC_854 0422-0053 192 µM -0.702300588104298 0.279503977843051 no 2441 0.24124586329484 3697 3596728 SGTC_529 4076-0302 30.3 µM -0.70315385110014 0.279263034677585 no 2442 0.240979937714225 3658 5816522 SGTC_2286 7945697 125 µM -0.704117893992633 0.2789909311474 no 2443 0.240679678690489 3669 1245733 SGTC_2138 5575593 77.673 µM -0.705422146584215 0.278623007948005 no 2444 0.240273782893375 3681 762213 SGTC_2725 haloperidol 53.21 µM -0.70871228026558 0.277695928710133 no 2445 0.239251521305674 3653 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_6 0844-0013 19.835 µM -0.709344347220518 0.277518000372632 no 2446 0.239055407287874 3786 1584900 SGTC_1962 st076595 64.5 µM -0.710448808051971 0.277207225844645 no 2447 0.238712932711408 3714 279619 SGTC_2293 7624732 200 µM -0.713076603174051 0.276468498789164 no 2448 0.237899178257179 3658 894453 SGTC_1301 naphtanilide LB 4.81 µM -0.714221965769627 0.27614681623894 no 2449 0.237544968124354 3738 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1157 4092-0394 27.6 µM -0.714252390451395 0.276138273774381 no 2450 0.237535563060306 3779 3659885 SGTC_930 2810-3379 265 µM -0.71501159870755 0.275925149726502 no 2451 0.23730093814516 3723 1015764 SGTC_2341 7987486 176.74 µM -0.719100326969569 0.274778757989114 no 2452 0.236039552941884 3699 1258686 SGTC_2865 9030313 51.95 µM -0.719399766419539 0.274694893956792 no 2453 0.23594732036682 3649 42562754 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.721711078154938 0.274047989724579 no 2454 0.235236064812496 3784 688664 SGTC_1270 0831-1170 17.3 µM -0.72388915640739 0.273439065452221 no 2455 0.234566893835109 3691 6764716 SGTC_1773 st048542 73.5835 µM -0.724358992994584 0.273307801353455 no 2456 0.234422684123313 3675 3237138 SGTC_1416 3966-0321 25.3 µM -0.724844699859715 0.273172136194409 no 2457 0.234273654838655 3738 582530 YLR208W SEC13 SGTC_594 1487-1584 10.8 µM -0.725429999677343 0.273008697585566 no 2458 0.234094137176998 3699 5013332 SGTC_1283 0922-0125 16.4 µM -0.726756362565148 0.272638504668095 no 2459 0.233687609674853 3727 3360884 SGTC_2478 5763493 32.33 µM -0.726892416677558 0.272600545542403 no 2460 0.233645931512305 3679 1365576 YLR208W SEC13 SGTC_2438 5259590 200 µM -0.729900184974489 0.271762048233888 no 2461 0.23272559962002 3752 1201127 SGTC_2674 ligustilide 100 µM -0.730467493546852 0.271604039529579 no 2462 0.232552237841549 3719 5319022 A signalling regulator. SGTC_1211 1056-0033 32.3 µM -0.731160036545427 0.271411212136351 no 2463 0.232340703489606 3725 6741922 SGTC_1811 st050069 61.5 µM -0.732764371690439 0.270964773159086 no 2464 0.231851077509978 3702 3877702 SGTC_1136 pergolide 1.05886 µM -0.732982717523124 0.270904042314328 no 2465 0.231784485150797 3724 47811 A dopamine receptor agonist. SGTC_1113 artemisinin 1.17947 µM -0.733958888526341 0.270632612601251 no 2466 0.231486897288068 3740 2240 An anti-malaria and mitochondrial poison. SGTC_2697 mebhydrolin 72.4 µM -0.73450881720413 0.270479761744139 no 2467 0.231319344177553 3726 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_478 N-arachidonylglycine 10 µM -0.737698989113197 0.269593915831022 no 2468 0.230348693276266 3670 5283389 SGTC_1828 st055811 49 µM -0.738128276935566 0.26947482238627 no 2469 0.230218250999279 3704 5877589 SGTC_1556 plumbagin 1.48 µM -0.740582938980385 0.268794354524443 no 2470 0.229473177875512 3662 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_904 1141-0088 396 µM -0.740970471623679 0.268687003800956 no 2471 0.229355672217418 3716 1378119 SGTC_1198 1612-1005 86.7 µM -0.741015359929134 0.268674570648248 no 2472 0.229342063596004 3790 6998509 SGTC_1731 st035964 63 µM -0.741452561453064 0.268553489790053 no 2473 0.229209542504633 3737 6739575 SGTC_901 1112-0062 60.1 µM -0.742453662340999 0.268276343060451 no 2474 0.228906258462467 3742 1908457 SGTC_3156 9099931 49.47 µM -0.74366739107552 0.267940525103433 no 2475 0.22853886092686 3772 18111053 SGTC_372 0155-0182 15.9 µM -0.744167298721824 0.267802270794952 no 2476 0.228387634485058 3713 771486 SGTC_409 arachidonic acid 100 µM -0.744818856010144 0.267622130270368 no 2477 0.228190617131607 3753 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2148 5546263 113.568 µM -0.745883540121115 0.267327901242897 no 2478 0.227868884563606 3746 792097 SGTC_2589 lobaric acid 100 µM -0.746926530290932 0.267039825744703 no 2479 0.227553955241786 3763 73157 A novel microtubule depolymerizer. SGTC_2634 4'-methoxyflavone 100 µM -0.74787379550841 0.266778325533735 no 2480 0.227268142438311 3766 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_431 k089-0097 107 µM -0.748387496855074 0.266636568269048 no 2481 0.227113230968839 3703 5499420 SGTC_2060 5238662 140 µM -0.748413262477479 0.266629459179529 no 2482 0.227105462671241 3737 790130 SGTC_1071 trifluoperazine 6.31 µM -0.748715786039153 0.266545995937891 no 2483 0.227014263463873 3837 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_777 1315-0167 517 µM -0.751435632720412 0.265796211167334 no 2484 0.226195262437057 3801 4221767 SGTC_955 1216-0110 33 µM -0.752575600166003 0.265482272639933 no 2485 0.22585249225338 3716 3619719 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.753433095076095 0.265246248981948 no 2486 0.225594850794785 3779 2374 Ca(2+)-ATPase inhibitor. SGTC_1743 st037606 46.3785 µM -0.753779458845292 0.265150943304189 no 2487 0.225490830103592 3774 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_945 3381-0768 11.3 µM -0.753875356035271 0.265124559246106 no 2488 0.225462034858677 3771 1126236 YIL048W NEO1 SGTC_3228 9131799 49.47 µM -0.75396856310512 0.265098916594866 no 2489 0.225434049376511 3760 17015818 SGTC_3009 9080819 71.4286 µM -0.754053669928321 0.265075503542303 no 2490 0.225408497716241 3796 17027216 SGTC_251 melphalan 456.522 µM -0.754340501496758 0.264996603356327 no 2491 0.225322394220014 3819 460612 A DNA alkylator. SGTC_296 1222-0039 74.9 µM -0.754484533567893 0.264956988239072 no 2492 0.225279164495153 3726 5984176 SGTC_57 miconazole 162.5 nM -0.755744442957579 0.264610586413882 no 2493 0.224901216133242 3689 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_226 1,3-diallylurea 8.28947 mM -0.75657056390868 0.26438357630416 no 2494 0.224653591119052 3713 74537 YKL182W FAS1 SGTC_3068 9116768 49.47 µM -0.757367941447903 0.264164558668271 no 2495 0.224414728517487 3715 41904888 SGTC_2511 berberine 10.47 µM -0.75793934029238 0.264007668013578 no 2496 0.224243648838192 3757 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1527 coumarin 137 µM -0.759542287522054 0.263567795689728 no 2497 0.223764113858331 3843 323 A hepatotoxic, DNA x-linker. SGTC_3257 9139206 32.98 µM -0.759999160372998 0.263442491571944 no 2498 0.223627543379022 3767 4910041 SGTC_1611 st001856 99.4 µM -0.760238821423405 0.263376773155936 no 2499 0.22355592178215 3759 647478 SGTC_2824 7998404 51.95 µM -0.76141367146398 0.263054733956511 no 2500 0.223205012074459 3761 837851 SGTC_1913 st060213 96.1 µM -0.761438982939476 0.263047798020357 no 2501 0.223197455376546 3793 688959 SGTC_1387 3342-1166 1.8 µM -0.761467883231003 0.263039878778973 no 2502 0.223188827421797 3781 3418228 SGTC_2303 7774051 200 µM -0.763245055766743 0.26255313321237 no 2503 0.222658631482156 3742 2953184 SGTC_1044 1222-0021 1.78 µM -0.763564766669383 0.262465617303713 no 2504 0.222563326213509 3788 4306703 SGTC_3022 9087993 49.47 µM -0.764659566727852 0.26216604591338 no 2505 0.222237144452553 3799 17173644 SGTC_2468 5987765 72.9 µM -0.764817996595407 0.262122709083698 no 2506 0.222189964890868 3811 26772094 SGTC_3218 9131285 49.47 µM -0.766653141205718 0.261620992199186 no 2507 0.221643885433155 3759 17156417 SGTC_369 0957-0393 4.5 µM -0.768539071400196 0.261105904854065 no 2508 0.221083493754874 3796 6997992 SGTC_882 0843-0131 351 µM -0.769171471033063 0.260933299943051 no 2509 0.220895762063343 3773 5425421 SGTC_1450 4112-4260 37.6 µM -0.769734953220727 0.260779554565294 no 2510 0.220728565848588 3759 1633175 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.770761484134479 0.260499586794108 no 2511 0.220424160364634 3780 1273210 SGTC_355 1311-2252 105 µM -0.773919390095483 0.259639296401191 no 2512 0.21948923113136 3802 5338538 SGTC_1026 k007-1105 30.6 µM -0.776954179662698 0.258813930067136 no 2513 0.218592902093009 3792 7066794 SGTC_522 1273-0010 11.6 µM -0.777836062333562 0.258574340851121 no 2514 0.218332832596952 3887 5705015 SGTC_2549 cedrol 20.94 µM -0.778907259933807 0.25828347325594 no 2515 0.218017173513729 3730 6708665 A sedative which affects the nervous system. SGTC_2271 7849410 118.62 µM -0.77963552109228 0.258085821770057 no 2516 0.217802720808393 3742 972430 SGTC_2263 7948595 193.29 µM -0.781234028315016 0.257652259007476 no 2517 0.217332431670139 3784 2971371 SGTC_2294 7971431 200 µM -0.781565953868502 0.257562278352384 no 2518 0.217234851021731 3763 5741572 SGTC_1359 1582-0056 520 nM -0.783022800660255 0.257167539433884 no 2519 0.216806861448544 3889 3661189 SGTC_2429 5902844 64.44 µM -0.783548619517573 0.257025143841897 no 2520 0.21665250724472 3849 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.783570790323191 0.257019140726813 no 2521 0.216646000398271 3838 6710655 SGTC_3185 9108267 49.47 µM -0.783627457762597 0.257003797404712 no 2522 0.216629369746948 3773 4910486 SGTC_592 k241-0073 46.5 µM -0.784728320828167 0.256705821388811 no 2523 0.216306437117945 3792 4230158 SGTC_1212 0520-0165 585 µM -0.786645067429848 0.256187435724967 no 2524 0.215744834695021 3894 5403258 SGTC_1571 st070080 73.4 µM -0.787765322571553 0.255884714746067 no 2525 0.215416994204461 3883 4315245 SGTC_79 0052-0007 94.094 µM -0.788449129772876 0.255700024718497 no 2526 0.215217021482326 3812 2801472 SGTC_2841 9004761 38.96 µM -0.78882367423449 0.255598893220242 no 2527 0.215107535306205 3811 2991039 SGTC_1629 st005085 44.9 µM -0.789341279286065 0.255459168038478 no 2528 0.214956283144698 3806 24207091 SGTC_3322 9139058 2.11 µM -0.78939467571056 0.25544475618244 no 2529 0.214940683403075 3935 4908926 YPR165W RHO1 SGTC_2167 5876490 200 µM -0.789448198785092 0.255430310569543 no 2530 0.214925047320569 3977 686534 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.789634295230665 0.255380087382604 no 2531 0.214870686763349 3617 4000243 SGTC_615 k087-0205 167 µM -0.790617409119643 0.255114853035725 no 2532 0.214583642338975 3811 9642773 SGTC_1792 st045773 43.6 µM -0.792249727663742 0.254674788142928 no 2533 0.214107539165597 3735 2919270 SGTC_2622 2-methoxyxanthone 59.94 µM -0.792759921054518 0.254537324151255 no 2534 0.213958855742876 3837 71034 A hepatoprotective. SGTC_765 1319-0117 244 µM -0.793395866187792 0.254366032669366 no 2535 0.213773609222788 3775 3487746 YGL099W LSG1 SGTC_3340 9146634 11.102 µM -0.79368770445101 0.254287446418971 no 2536 0.213688629987265 3846 4907387 SGTC_415 dibenzyl ketone 100 µM -0.795673666704022 0.253753004426675 no 2537 0.213110868259424 3848 7593 SGTC_1389 3405-0187 19 µM -0.79625054468594 0.253597871495898 no 2538 0.212943212236275 3786 799890 SGTC_2077 5212015 200 µM -0.796886285706541 0.253426966949669 no 2539 0.212758538234019 3717 780900 SGTC_1194 1488-0194 225 µM -0.796904695554002 0.253422018781916 no 2540 0.212753191820506 3779 1391452 SGTC_1655 st012546 55.1 µM -0.797117211045296 0.253364902902829 no 2541 0.212691480763413 3788 720985 YLR208W SEC13 SGTC_2475 5812728 15.03 µM -0.797424103994153 0.253282433984998 no 2542 0.212602382468219 3813 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1933 st074711 15.9 µM -0.798738942831591 0.252929267553765 no 2543 0.212220900432275 3817 17250958 SGTC_3016 9080866 49.47 µM -0.798816264312959 0.252908507032986 no 2544 0.212198479153578 3823 17066299 SGTC_336 4111-0029 111 µM -0.800749239992658 0.252389802085982 no 2545 0.211638415142402 3818 3131175 SGTC_2008 4012253 172 µM -0.803016166323312 0.251782198220086 no 2546 0.21098269531252 3849 603940 SGTC_1910 st062352 60.4 µM -0.803953146300532 0.251531285408863 no 2547 0.21071201740785 3785 2245730 SGTC_286 k060-0067 22.9 µM -0.804521347503046 0.251379191825262 no 2548 0.210547972819153 3834 5985051 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.804577279985496 0.251364222694481 no 2549 0.210531828681981 3897 688788 SGTC_1523 st012844 44.7 µM -0.804920227589579 0.251272450417371 no 2550 0.210432857485374 3969 4274103 SGTC_245 methotrexate 289.6 µM -0.806303255574155 0.250902534008573 no 2551 0.210034006903242 3838 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1738 st035555 74 µM -0.806935649207862 0.250733484720758 no 2552 0.209851779380934 3888 5331140 SGTC_2528 xanthyletin 44.79 µM -0.808721316646587 0.250256472043772 no 2553 0.209337731954101 3902 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3042 9091578 49.47 µM -0.808991125488397 0.250184438770065 no 2554 0.209260125469548 3773 25236497 SGTC_759 3486-0358 89.3 µM -0.809683351689622 0.249999679274407 no 2555 0.209061094416183 3825 875103 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.809915954165894 0.249937612476588 no 2556 0.20899424085234 3836 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_966 1300-0360 30.2 µM -0.810250026066338 0.249848484256567 no 2557 0.208898245432498 3843 70588 SGTC_2124 5246320 200 µM -0.812550778129085 0.249235117016744 no 2558 0.20823783109809 3866 579342 SGTC_1928 4'-methoxychalcone 40.3 µM -0.814835948192033 0.248626697364954 no 2559 0.207583110435722 3911 641818 SGTC_2179 6298986 200 µM -0.816349253642929 0.24822422019445 no 2560 0.20715020584144 3784 738374 SGTC_313 3474-0040 5.03 µM -0.817281132519977 0.247976551594683 no 2561 0.206883893250985 3844 1043375 YIL048W NEO1 SGTC_1103 duloxetine 36.1 µM -0.817355653942025 0.247956751480164 no 2562 0.206862605253467 3952 60835 A selective serotonin reuptake inhibitor. SGTC_2955 9076254 12.21 µM -0.817606269610028 0.247890169851721 no 2563 0.20679102319468 3806 16459619 SGTC_421 streptovitacin 30 mM -0.817852662476311 0.24782471940847 no 2564 0.206720661570349 3953 91467 include heat shock SGTC_1659 st012954 42.1 µM -0.817996958725594 0.247786393631698 no 2565 0.206679461933517 3863 24207262 SGTC_1854 st056233 32.9 µM -0.822429114189281 0.246610734764564 no 2566 0.205416357517798 3768 5393174 SGTC_2031 5180455 200 µM -0.823440345776093 0.246342918049397 no 2567 0.205128813794992 3835 29949 SGTC_235 0330-0087 5 mM -0.823968205805674 0.246203180435569 no 2568 0.20497881185172 3885 46494818 YHR062C RPP1 SGTC_607 4491-0986 66.8 µM -0.824363343512395 0.246098605529321 no 2569 0.204866568288537 3876 698981 YDR232W HEM1 SGTC_2011 4012611 177 µM -0.826162955651844 0.245622631879589 no 2570 0.204355829525111 3898 2049887 SGTC_1569 carminic acid 40.6 µM -0.827080890029038 0.245380040904251 no 2571 0.204095607435414 3930 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2210 7115885 190.385 µM -0.829688060374452 0.244691722804869 no 2572 0.203357586854304 3918 2927039 SGTC_1886 st057356 49.9 µM -0.831701937691572 0.244160752295271 no 2573 0.202788603328908 3847 24207747 SGTC_2443 5493264 126.67 µM -0.834684928202495 0.243375412482399 no 2574 0.201947564937599 3902 5340055 SGTC_1716 st033144 30.6155 µM -0.835851005221157 0.243068787790864 no 2575 0.201619364149467 3854 674617 SGTC_3174 9107204 49.47 µM -0.836528763290963 0.242890664603617 no 2576 0.201428751168475 3919 3938802 SGTC_3226 9131256 49.47 µM -0.837108832874871 0.242738271264817 no 2577 0.201265697943552 3769 17178073 SGTC_161 4065-0411 162.148 µM -0.839450806408878 0.242123524886825 no 2578 0.200608191795705 3934 1906281 YLR208W SEC13 SGTC_496 calpeptin 138 µM -0.839480126028229 0.242115834111816 no 2579 0.200599968531573 3898 73364 A calpain inhibitor. SGTC_1262 0737-0114 49.6 µM -0.840281063969531 0.241905792804577 no 2580 0.200375408017896 3936 765919 SGTC_1579 chlormadinone acetate 49.4 µM -0.840883445961113 0.241747886793262 no 2581 0.20020661655928 3934 45114258 A steroidal progestin. SGTC_2382 9035899 200 µM -0.841732209116965 0.241525490383586 no 2582 0.199968932524497 3888 6462679 SGTC_1024 4507-0395 26 µM -0.841770581996205 0.24151543838992 no 2583 0.199958190756418 3972 4201836 SGTC_3286 9117135 37.221 µM -0.842248922553 0.241390153434559 no 2584 0.199824317407821 3858 3438150 SGTC_1055 3448-0672 86 µM -0.842293748986204 0.241378414492561 no 2585 0.199811774580706 3934 748378 SGTC_1507 4075-3230 155 µM -0.842653525035141 0.241284209215457 no 2586 0.19971112325713 3781 659771 SGTC_2123 5259487 200 µM -0.842760961016711 0.24125608159963 no 2587 0.19968107277011 3895 2173474 SGTC_1752 st044819 83.042 µM -0.84535233850621 0.240578177998188 no 2588 0.198957073463352 3909 441209 YML126C ERG13 SGTC_2669 eugenol 100 µM -0.850310590264159 0.239283996328439 no 2589 0.197576215120737 3871 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2551 apiole 73.87 µM -0.851137877992231 0.239068432075956 no 2590 0.19734638322582 3725 10659 A possible DNA adduct former. SGTC_2173 5763948 167 µM -0.85169082574511 0.23892441109885 no 2591 0.197192856942126 3893 2867177 SGTC_2700 st077718 96.8 µM -0.854309164604314 0.238243082267087 no 2592 0.19646685530808 3900 904970 SGTC_1449 4112-4002 201 µM -0.855702413383466 0.237880973538268 no 2593 0.196081202483861 3965 2059539 SGTC_1330 1469-0054 61.8 µM -0.856643020257761 0.237636678288373 no 2594 0.195821101260897 3935 7102664 SGTC_143 4032-1194 15.74 µM -0.856918365473303 0.23756519144069 no 2595 0.195745001088691 3927 1806963 SGTC_1379 2144-0755 36.5 µM -0.858262858993251 0.237216295190115 no 2596 0.195373666588634 3994 5392327 SGTC_209 4077-0173 175.592 µM -0.858321824265488 0.237201000139427 no 2597 0.195357390822531 3875 15993494 SGTC_2363 9053361 176 µM -0.858348034694849 0.237194201568424 no 2598 0.195350156407964 3976 6469797 YMR079W SEC14 SGTC_3053 9095903 49.47 µM -0.858384335056031 0.237184786005411 no 2599 0.195340137311641 3996 17174018 SGTC_863 0466-0191 129 µM -0.858480262160179 0.237159905486569 no 2600 0.195313662413814 3955 765160 YPR165W RHO1 SGTC_390 dec-rvkr-cmk 16.7 µM -0.859054518828283 0.237010991086943 no 2601 0.195155219050367 3959 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1072 oxiconazole 14.9 nM -0.863475837238854 0.235866191681436 no 2602 0.193937949426322 3910 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_330 1488-0319 80.1 µM -0.864614231632507 0.235571924684516 no 2603 0.19362527931905 3968 6846614 SGTC_1277 0873-0036 22 µM -0.866071468473165 0.23519553489362 no 2604 0.19322548521803 3992 5965735 SGTC_1128 3448-9350 235 µM -0.866712430973177 0.235030085870072 no 2605 0.193049796301724 3986 619386 SGTC_1820 st053765 18.6 µM -0.866831722976464 0.234999300612564 no 2606 0.193017108929052 3982 3690829 SGTC_811 0416-0114 265 µM -0.867020958387311 0.234950469882381 no 2607 0.192965263196562 4005 6612453 SGTC_1645 Cervolide 78 µM -0.867214607763199 0.23490050596765 no 2608 0.192912216954514 3910 23173 A fragrance. SGTC_2960 9079389 5.97 µM -0.867443650949448 0.234841417596188 no 2609 0.192849486808551 3938 16457355 SGTC_1974 st069448 26.9 µM -0.869393252135762 0.234338793819349 no 2610 0.192316036334029 3915 6323587 YNR016C ACC1 SGTC_1166 k206-0078 225 µM -0.872004937939254 0.233666412979763 no 2611 0.191602841862345 3960 5404595 SGTC_53 0973-0023 39.979 µM -0.87205482855006 0.233653579017229 no 2612 0.191589233612256 3833 674768 SGTC_642 0335-0876 158 µM -0.873696006377304 0.233231617032792 no 2613 0.19114191320023 3961 6812350 SGTC_3230 9131665 49.47 µM -0.874426583487484 0.233043915040207 no 2614 0.190942992814772 3851 15943720 SGTC_2792 7535235 81.82 µM -0.875429008629074 0.232786505628345 no 2615 0.190670260817651 3940 1281891 SGTC_1759 st043059 70 µM -0.87564560654743 0.23273090693463 no 2616 0.190611361977311 3964 669426 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.876048790191223 0.232627433057914 no 2617 0.190501755172781 3937 77254 SGTC_3180 9109287 49.47 µM -0.876426880125444 0.232530422522838 no 2618 0.190399005344507 4000 18891271 SGTC_3345 9148410 3.559 µM -0.877295015387621 0.232307761017999 no 2619 0.190163209483915 3913 4903596 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.877393676586854 0.232282463655348 no 2620 0.190136423288271 3854 1241132 A phosphatase inhibitor. SGTC_1204 4049-0315 18.3 µM -0.877858986544208 0.232163175868431 no 2621 0.190010124399085 4055 588402 SGTC_2435 5706476 10.6 µM -0.879674788550126 0.23169799953163 no 2622 0.189517755446138 3948 5725375 SGTC_3149 9097855 49.47 µM -0.881575750763441 0.2312115636311 no 2623 0.189003136629244 3965 25236625 YMR079W SEC14 SGTC_2522 biochanin a 4.94 µM -0.884768330813397 0.230395900008121 no 2624 0.188140796642984 3956 5280373 A possible chelator. SGTC_2479 5617353 43.85 µM -0.885171418229151 0.230293030800363 no 2625 0.188032092590273 3990 2731746 SGTC_298 1391-0729 10 µM -0.885946438733467 0.230095315257917 no 2626 0.187823195103092 3906 3237558 SGTC_610 4215-0184 155 µM -0.886364193405966 0.229988781236763 no 2627 0.187710653810962 3967 5605015 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.886904677116202 0.229850990348773 no 2628 0.187565111673156 3974 551469 SGTC_2899 9053889 58.44 µM -0.888255210652325 0.229506887513303 no 2629 0.187201743207053 3909 6470052 SGTC_33 0986-0033 35.816 µM -0.8894465013664 0.229203597966329 no 2630 0.186881581512306 3862 2848082 SGTC_771 0250-0039 27.3 µM -0.892743702068156 0.228365339834234 no 2631 0.185997220602239 3911 3005115 SGTC_1396 3511-0007 98.6 µM -0.895655138822622 0.227626590218656 no 2632 0.185218488519102 3972 X1396 SGTC_1406 3909-7906 11.9 µM -0.896816413202977 0.227332303588373 no 2633 0.184908444136329 3967 X1406 SGTC_3134 9127454 49.47 µM -0.89705376529284 0.227272180937534 no 2634 0.18484511409272 4025 24262820 SGTC_1565 sinapyl alcohol 95.1 µM -0.897176548491161 0.227241082763348 no 2635 0.18481235849569 4011 5280507 A phenol propionate derived from cinnamic acid. SGTC_2766 oltipraz 83.91 µM -0.898359229113885 0.226941659653638 no 2636 0.18449703259177 3909 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1981 st071826 47 µM -0.901220411406841 0.226218205880592 no 2637 0.183735570226654 3994 11838600 SGTC_3027 9089541 49.47 µM -0.90174038095098 0.226086870947333 no 2638 0.183597398369338 3995 9943819 SGTC_1892 st058411 7.36 µM -0.901754955988079 0.226083190176737 no 2639 0.183593526268099 3998 3934738 SGTC_846 0335-0850 148 µM -0.901882203130463 0.226051056703008 no 2640 0.183559723108076 3959 6819598 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.902352166726073 0.225932400085817 no 2641 0.183434911059673 4031 61125 An anti-inflammatory. SGTC_1411 3909-8223 150 µM -0.902904749466747 0.225792928807819 no 2642 0.183288224864716 3983 X1411 SGTC_595 3909-8003 73.7 µM -0.903673268519739 0.225599036426224 no 2643 0.183084338806327 4044 699517 SGTC_1410 3909-8106 77.9 µM -0.906894947956377 0.224787253701941 no 2644 0.182231176507903 4012 1039210 SGTC_2926 9010726 65.15 µM -0.910306661942155 0.223929395649994 no 2645 0.181330403087819 4025 2994293 SGTC_1705 st027868 56.3335 µM -0.91278481742264 0.223307444266518 no 2646 0.180677862454642 3930 292948 SGTC_2304 7443016 91.4 µM -0.914451036107581 0.222889820820368 no 2647 0.180239947524889 3915 939854 SGTC_2616 abietic acid 100 µM -0.916821294667372 0.22229650318892 no 2648 0.179618145993522 4006 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2492 derrusnin 100 µM -0.918252767815879 0.221938617005104 no 2649 0.179243274336963 3904 1715307 Part of coumarin class of compounds. SGTC_2804 7954240 19.48 µM -0.918851238479798 0.221789089444182 no 2650 0.179086693864164 4044 828705 SGTC_694 1315-0438 43.2 µM -0.919296890256359 0.221677780988643 no 2651 0.178970151974696 3966 6793154 SGTC_3157 9099274 49.47 µM -0.920038206978151 0.221492696346717 no 2652 0.178776396829822 3981 17217662 SGTC_775 4577-0580 57.3 µM -0.921360678827749 0.22116273409177 no 2653 0.178431075421602 4073 2006902 SGTC_557 1315-0110 16.2 µM -0.921816018216641 0.221049190127734 no 2654 0.178312275354236 3974 6833801 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.923275836043161 0.220685393244388 no 2655 0.17793173855316 3969 140250 A respiratory chain inhibitor. SGTC_446 go6976 132 µM -0.923459493797893 0.220639648737626 no 2656 0.177883900015529 4016 3501 A protein kinase C inhibitor. SGTC_1266 0828-0227 32.9 µM -0.924283393250294 0.220434503052143 no 2657 0.177669393365737 4017 3913820 SGTC_169 k015-0017 16.025 µM -0.925598798612903 0.220107202247386 no 2658 0.177327258980711 3962 1840002 SGTC_3010 9080089 71.4286 µM -0.927184580433388 0.219712996871776 no 2659 0.176915353668764 4017 17027233 SGTC_670 4204-0025 119 µM -0.929484993457875 0.219141864332392 no 2660 0.176318899348107 4015 719039 SGTC_276 colchicine 750 µM -0.931170600999655 0.218723914380572 no 2661 0.175882661384546 4091 2833 A microtubule depolymerizer. SGTC_816 0325-0417 81.3 µM -0.932235449510025 0.218460119562747 no 2662 0.175607429482859 4043 68101 SGTC_1373 2887-0003 58.5 µM -0.933643497168501 0.21811158552907 no 2663 0.175243910030308 3992 776948 SGTC_990 3985-0011 41.3 µM -0.93409857401422 0.217999008927048 no 2664 0.175126523730192 4006 5399565 YGL099W LSG1 SGTC_1229 0139-0193 12.2 µM -0.935451608342052 0.217664494149315 no 2665 0.174777805504061 4080 3090752 SGTC_2497 7-hydroxyflavone 100 µM -0.93645252835197 0.217417224367945 no 2666 0.174520121719893 4059 5281894 SGTC_865 0488-0499 301 µM -0.937094768060051 0.217258649317943 no 2667 0.174354906226596 4024 9634651 SGTC_2041 5107442 45.335 µM -0.937156210892192 0.217243482004231 no 2668 0.174339105331989 4059 793005 SGTC_2408 sulbentine 18.36 µM -0.937534569821938 0.217150096654758 no 2669 0.174241825025351 4007 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2027 5150920 200 µM -0.941767357958955 0.21610695543687 no 2670 0.173155880300367 3957 786715 SGTC_2312 7706453 155.7 µM -0.942092319424603 0.216026991079652 no 2671 0.173072688219297 4033 976098 SGTC_3353 9151644 39.2805 µM -0.944294838897805 0.215485461694876 no 2672 0.172509501299502 4066 4909158 SGTC_318 1488-0629 67.2 µM -0.945164776979071 0.215271788735624 no 2673 0.172287379406991 4076 3662576 SGTC_2490 carminic acid 95.39 µM -0.947090854568772 0.214799146013617 no 2674 0.171796242262411 3983 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_359 0081-0058 15.9 µM -0.947535809410266 0.214690043746873 no 2675 0.171682908967639 4111 3494159 SGTC_810 3825-7150 143 µM -0.947755539064052 0.214636178242336 no 2676 0.17162695981728 4094 22330411 YGL099W LSG1 SGTC_449 xestospongin c 11.1929 µM -0.947762679209107 0.214634428007203 no 2677 0.171625141937449 4034 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_754 3474-0146 171 µM -0.948436018202408 0.214469412398505 no 2678 0.171453765215622 3989 24762078 SGTC_257 daunorubicin 18.5 µM -0.951315849798121 0.213764483193622 no 2679 0.170722031708962 4055 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2152 5568786 200 µM -0.951586026814244 0.213698418196921 no 2680 0.170653485412211 4011 5399883 SGTC_3006 9075424 71.4286 µM -0.952057969047945 0.213583045126081 no 2681 0.170533791769626 3975 7465181 SGTC_728 3030-5151 22.5 µM -0.954348196054939 0.213023681817725 no 2682 0.169953709690157 4069 3125388 SGTC_1245 0418-0076 17.2 µM -0.959005926381415 0.211888721676121 no 2683 0.168777879826178 4103 6790114 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.960124231670613 0.211616749148056 no 2684 0.168496347134152 4057 688751 SGTC_3204 9114183 49.47 µM -0.96155133878589 0.211269972783573 no 2685 0.168137512550173 4032 17027248 SGTC_314 1671-0008 2.74 µM -0.962539365948101 0.211030084721302 no 2686 0.167889369344125 3933 3913060 SGTC_406 estrone 100 µM -0.962681797081993 0.210995516325533 no 2687 0.167853617190347 4040 5870 A steroid. SGTC_1696 st025591 34.7925 µM -0.965240741964452 0.210375019727249 no 2688 0.167212122388989 4055 2787147 SGTC_1091 telmisartan 47.6 µM -0.965732183792575 0.210255976957852 no 2689 0.167089105336007 4101 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3034 9090421 49.47 µM -0.968739578446526 0.209528352967464 no 2690 0.166337569993705 3915 17173761 SGTC_2833 9001315 45.46 µM -0.969821785178896 0.209266881350557 no 2691 0.166067665964083 4019 2989378 SGTC_2727 riluzole 51.77 µM -0.969949055291371 0.209236144286521 no 2692 0.166035943207383 4074 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3217 9129673 49.47 µM -0.970220152136564 0.209170680421586 no 2693 0.165968383921835 4104 17248312 SGTC_2048 5246248 200 µM -0.970411668522366 0.209124440738743 no 2694 0.165920667369143 4068 677046 SGTC_1358 1509-0022 2.48 µM -0.972516607326126 0.208616621411284 no 2695 0.16539680350746 4083 3258434 SGTC_2125 5246583 200 µM -0.972578515072662 0.208601697096558 no 2696 0.165381412515429 4053 835267 SGTC_333 3486-0131 40.1 µM -0.97272188520681 0.208567136778894 no 2697 0.165345772576189 4108 6744690 SGTC_2820 7989630 71.43 µM -0.973774097459373 0.208313597386856 no 2698 0.165084358467843 4035 2984098 SGTC_290 2043-6722 48.1 µM -0.975868108539276 0.207809569106356 no 2699 0.164564913927522 4075 773758 YLR208W SEC13 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.975975521938156 0.207783734146397 no 2700 0.164538297337587 4024 688761 SGTC_666 0272-0154 136 µM -0.977231362554145 0.207481821429703 no 2701 0.164227312311643 4076 6870312 SGTC_715 0868-0130 184 µM -0.977972623705405 0.207303738908503 no 2702 0.164043932104656 4117 2876258 SGTC_32 0928-0142 34.1 µM -0.980198928200895 0.206769429322464 no 2703 0.16349396674554 4056 2244242 SGTC_1994 st072947 40.9 µM -0.980615818200492 0.206669467084348 no 2704 0.163391115414779 4126 5286565 YDL195W SEC31 SGTC_659 k018-0002 107 µM -0.98127616384308 0.206511187423969 no 2705 0.163228286939755 4081 6797879 YHR007C ERG11 SGTC_586 0957-0265 8.15 µM -0.981855139277385 0.206372470662195 no 2706 0.163085609566397 3951 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1876 myriocin 605 nM -0.982410703846202 0.206239414836619 no 2707 0.162948777584132 4069 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1907 st060210 83.7 µM -0.987322082424736 0.20506536979914 no 2708 0.161742384238464 4124 688793 SGTC_2471 5466956 24.79 µM -0.989697300761545 0.20449901151798 no 2709 0.161161047368306 4034 724419 SGTC_2767 sibutramine 71.45 µM -0.990354746944698 0.204342411592189 no 2710 0.161000378004492 4107 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2190 6049624 200 µM -0.992627956684449 0.203801496474105 no 2711 0.160445647728285 3946 2265554 SGTC_2277 7947813 106.88 µM -0.99356172367673 0.203579552155114 no 2712 0.160218143296251 4154 1246798 SGTC_2837 9008476 45.46 µM -0.993659217459475 0.203556387459548 no 2713 0.160194401923962 4112 2992805 SGTC_2333 9017922 200 µM -0.99521208839629 0.203187634548358 no 2714 0.159816561840777 4140 3163164 SGTC_424 splitomicin 100 mM -0.995362852112901 0.203151854650566 no 2715 0.159779909521315 4151 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_87 0100-0052 35.5 µM -0.9961353338361 0.202968584960538 no 2716 0.159592196993026 4135 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_979 1426-2828 121 µM -0.996315576106334 0.202925837066445 no 2717 0.159548419020528 4183 747872 SGTC_1501 4491-0275 38.4 µM -0.996405486672287 0.202904515070295 no 2718 0.159526584116815 4033 5104718 SGTC_2097 5376186 200 µM -0.997475479507641 0.202650872511648 no 2719 0.159266885047598 4056 742755 SGTC_943 3253-1379 105 µM -0.998124516250139 0.202497110268206 no 2720 0.159109491651653 4116 668464 SGTC_1316 1272-0050 65.9 µM -0.99819172745527 0.20248119135694 no 2721 0.159093198552956 4047 7340392 SGTC_2812 7970281 58.44 µM -0.998711735767711 0.202358053163114 no 2722 0.15896717695136 4144 2233435 SGTC_3296 9122258 64.045 µM -0.998748803008514 0.202349277334722 no 2723 0.158958196375802 4091 4730474 SGTC_2563 tomatine 8.54 µM -1.00206766896068 0.201564444447915 no 2724 0.158155455817874 3989 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1138 3761-0006 1.03 µM -1.00247876118966 0.201467358011285 no 2725 0.158056209654889 4108 12061087 SGTC_2352 9027995 87.8 µM -1.00419152638822 0.201063161011857 no 2726 0.157643152827179 4046 2997347 SGTC_662 k832-1615 104 µM -1.00635325044102 0.200553708745682 no 2727 0.157122836714279 4116 5878478 SGTC_2929 9013348 24.6 µM -1.0064621580705 0.200528063073321 no 2728 0.157096653112717 4093 2995952 SGTC_1955 wogonin 32.4 µM -1.00689586964501 0.200425951798038 no 2729 0.156992408530858 4168 5281703 A flavanone. SGTC_2750 bromebric acid 70.15 µM -1.00691775019015 0.200420801159887 no 2730 0.156987150646687 4144 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2364 9055074 200 µM -1.00842819760344 0.200065436963328 no 2731 0.1566244708859 4124 6470630 SGTC_1498 4478-3555 97.6 µM -1.0089995536768 0.199931112354306 no 2732 0.156487424118293 4060 3437919 SGTC_1158 4092-0494 91.8 µM -1.00930917607899 0.199858343442705 no 2733 0.15641319038315 4193 1148199 SGTC_2872 9044037 25.97 µM -1.01021445307785 0.199645672382264 no 2734 0.156196278114614 4092 6465195 SGTC_2018 5133068 143 µM -1.01038185094819 0.199606361571461 no 2735 0.156156189846537 4057 785362 SGTC_374 0880-0231 82.3 µM -1.01078347471592 0.19951206541314 no 2736 0.156060037049983 4010 6833587 SGTC_1925 st057770 10.1 µM -1.01202358524789 0.199221072472761 no 2737 0.155763388320043 4090 5989122 SGTC_1349 flufenamic acid 69 µM -1.01263728044718 0.199077162998412 no 2738 0.155616722978783 4021 3371 A non-steroidal anti-inflammatory. SGTC_864 0469-0573 172 µM -1.01267766547342 0.199067695041546 no 2739 0.15560707466689 4079 689425 SGTC_1567 st069303 68.4 µM -1.01353550151786 0.198866646112095 no 2740 0.155402223851651 4175 5581319 SGTC_1853 st056710 91.2 µM -1.01471853436958 0.19858958247535 no 2741 0.155120008257354 4173 269167 SGTC_3073 9114972 49.47 µM -1.01554850350204 0.198395344604899 no 2742 0.154922219031594 4122 41905075 SGTC_1920 st075728 45.7 µM -1.01564869483192 0.198371904561536 no 2743 0.154898353794952 4084 3400306 SGTC_480 am 92016 50 µM -1.01645811358997 0.198182600059405 no 2744 0.154705642032267 4084 2129 K+ channel blocker. SGTC_2187 6125751 200 µM -1.01697394998321 0.198062014663502 no 2745 0.15458291098295 4129 874498 SGTC_2583 asiatic acid 100 µM -1.01862340796837 0.197676723684496 no 2746 0.154190893509278 4152 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2701 st077767 14.721 µM -1.01882589879282 0.197629455816585 no 2747 0.15414281400012 4086 5721188 SGTC_2455 5377712 9.75 µM -1.02006732853758 0.197339815566981 no 2748 0.153848265173416 4108 2243908 SGTC_2103 5378138 10 µM -1.02259223900974 0.196751516748677 no 2749 0.153250340310268 4183 244142 SGTC_3300 9124615 50.48 µM -1.02279805495961 0.196703608930324 no 2750 0.153201668933695 4178 24824903 SGTC_2879 9041815 71.43 µM -1.02292766409881 0.196673443411978 no 2751 0.153171024208423 4122 4942971 SGTC_3352 9151559 45.5865 µM -1.02977387518225 0.195084026867758 no 2752 0.151558083576221 4128 17159339 SGTC_1630 st005209 31.3 µM -1.03209027460147 0.194548024289544 no 2753 0.151014914691073 4087 3367314 SGTC_2975 9084847 53.72 µM -1.03264153464204 0.194420597780024 no 2754 0.150885841653371 4178 27211724 SGTC_2595 hexamethylquercetagetin 100 µM -1.03278722642138 0.194386928888536 no 2755 0.150851741384782 4103 386331 SGTC_3092 9117248 49.47 µM -1.03389247866599 0.194131624352387 no 2756 0.150593215788283 4228 17141857 SGTC_2289 7946404 165.07 µM -1.0352048436265 0.193828743808871 no 2757 0.150286628621921 4142 1246120 YPR165W RHO1 SGTC_3224 9130643 49.47 µM -1.0355897582035 0.193739964081884 no 2758 0.150196786034204 4186 17644395 SGTC_1938 st074717 56.4 µM -1.03573595327126 0.193706250998309 no 2759 0.150162672148664 4020 17250979 SGTC_739 1486-1183 203 µM -1.03590641111816 0.193666947351625 no 2760 0.150122903187412 4138 4346692 SGTC_751 0833-0568 350 µM -1.03599456206176 0.193646623685616 no 2761 0.150102339734394 4157 6954252 SGTC_1983 st071813 46.9 µM -1.03711212777517 0.19338907578021 no 2762 0.14984180187585 4184 11838595 SGTC_840 0245-0196 390 µM -1.03736155915445 0.193331621769437 no 2763 0.149783693188506 4208 3827528 SGTC_2781 5567276 71.43 µM -1.04284011836397 0.192072318954347 no 2764 0.148511173629152 4185 2853274 SGTC_2486 5283202 22.39 µM -1.04306849788963 0.192019932796143 no 2765 0.148458284730904 4187 1377751 SGTC_230 MPP+ 141.667 µM -1.04668185536438 0.191192257544126 no 2766 0.147623167495348 4128 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1430 4049-0248 69.1 µM -1.0469939510625 0.191120871701024 no 2767 0.147551184023506 4152 22774488 SGTC_833 3852-0053 558 µM -1.05124846269114 0.19014936528601 no 2768 0.146572245203846 4213 3123681 SGTC_2897 9048598 12.99 µM -1.05264826739389 0.189830388211683 no 2769 0.146251113348863 4124 6467404 SGTC_3107 9121808 49.47 µM -1.05308005366297 0.189732062408106 no 2770 0.146152151865677 4033 662681 SGTC_1155 4088-0394 48.2 µM -1.05336771480006 0.189666573979157 no 2771 0.146086247520709 4107 2326248 SGTC_186 3455-3465 67.277 µM -1.05672237612232 0.188903884589473 no 2772 0.145319154867926 4112 755278 SGTC_2991 9074669 71.4286 µM -1.05681174774756 0.18888359163581 no 2773 0.145298755857403 4148 17333109 SGTC_2270 7924575 90.91 µM -1.05687572726849 0.188869065104397 no 2774 0.145284153760078 4144 1262135 SGTC_2852 9023854 51.95 µM -1.05733749049088 0.188764242315161 no 2775 0.14517879444774 4207 19798528 SGTC_237 nikkomycin 200 µM -1.05773272564265 0.188674550248324 no 2776 0.145088655519804 4156 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1561 5-methoxyflavone 52.9 µM -1.05884418072882 0.188422464787006 no 2777 0.144835374512748 4078 94525 SGTC_254 nsc-64875 3.808 µM -1.06176119317463 0.187761855479887 no 2778 0.14417205562379 4163 56993 SGTC_1613 st002381 52.1 µM -1.0628074342811 0.187525264571687 no 2779 0.143934643722569 4144 551167 SGTC_293 4049-0273 38.5 µM -1.06603045169485 0.186797588703818 no 2780 0.143204938267856 4024 1380311 SGTC_2355 9061122 103.12 µM -1.066814256954 0.186620889824151 no 2781 0.143027859659861 4173 5302957 SGTC_7 0192-1582 4.227 µM -1.06767673070512 0.18642657577527 no 2782 0.142833179167504 4200 252616 SGTC_2985 9022375 71.43 µM -1.0689390669476 0.186142399348058 no 2783 0.142548563414179 4232 4939335 SGTC_1234 0326-0494 15.5 µM -1.06928307855299 0.186065002226212 no 2784 0.142471066538792 4244 1547813 SGTC_3330 9141424 71.43 µM -1.07218730351746 0.185412393322934 no 2785 0.141817955973669 4238 27261020 SGTC_627 1391-0720 175 µM -1.07455528977686 0.184881335686121 no 2786 0.141286939138457 4153 997839 SGTC_405 ebelactone b 50 µM -1.07512268386947 0.184754229287097 no 2787 0.141159902421308 4130 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2172 5754775 163.918 µM -1.07516066227098 0.1847457233878 no 2788 0.14115140201235 4139 2263357 SGTC_3045 9092950 49.47 µM -1.0771464032622 0.184301322598048 no 2789 0.140707432586876 4107 44120432 SGTC_1673 st016611 27.3 µM -1.07735811430213 0.184253981795817 no 2790 0.140660154468336 4194 5226799 SGTC_2981 9013952 38.96 µM -1.07778917589045 0.184157615309676 no 2791 0.140563925545665 4141 2996344 SGTC_1357 1503-1303 39.5 µM -1.07806216202946 0.184096603795795 no 2792 0.14050300803807 4135 292895 SGTC_163 TUB2.036 7.546 µM -1.07839618737982 0.184021967336733 no 2793 0.140428493870179 4149 15992207 YJR013W GPI14 SGTC_2813 7971799 71.43 µM -1.07906553592097 0.183872461133918 no 2794 0.140279256780587 4203 2234054 SGTC_3260 9137109 49.47 µM -1.0796587472536 0.18374002424642 no 2795 0.140147085208491 4109 17478346 SGTC_66 0109-0187 42.4 µM -1.08009666204455 0.18364229609202 no 2796 0.14004956906975 4065 759417 SGTC_2328 6201408 200 µM -1.08054813581634 0.183541575935795 no 2797 0.139949081854768 4182 2890418 SGTC_1614 st002383 48.6 µM -1.08202370536701 0.18321262848324 no 2798 0.139620997356658 4194 1947235 SGTC_2849 9019321 12.99 µM -1.08474355911923 0.182607258043786 no 2799 0.139017624788657 4208 16489627 SGTC_2778 tioconazole 65.09 nM -1.08973331917542 0.181499916353137 no 2800 0.137915317225088 4075 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2561 acetosyringone 100 µM -1.09048343681198 0.181333812297702 no 2801 0.13775012275668 4159 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2091 4-phenylthiadiazole 200 µM -1.09069822524869 0.181286267652559 no 2802 0.137702845903436 4192 270010 SGTC_1605 st000082 49.1 µM -1.09409522247664 0.180535361273624 no 2803 0.136956608779104 4149 1114022 SGTC_2830 7992007 71.43 µM -1.09663158292306 0.179975972679662 no 2804 0.136401237719787 4068 1952075 SGTC_2716 st080858 38.6235 µM -1.0978978262961 0.179697113315686 no 2805 0.136124553629674 4170 5296050 SGTC_76 0433-0009 400.328 µM -1.09802449921974 0.179669231624642 no 2806 0.136096895755452 4256 2841569 SGTC_482 fipronil 114 µM -1.09884034573082 0.179489722631349 no 2807 0.135918855297334 4289 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1996 st072960 66.8 µM -1.10051640152876 0.179121297445154 no 2808 0.135553593700185 4221 1719405 SGTC_1806 st050005 60.3 µM -1.10287969808704 0.178602614172149 no 2809 0.13503970588146 4245 5194765 SGTC_1064 honokiol 6.76 µM -1.10409162381302 0.178336994678482 no 2810 0.134776697194812 4208 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3015 9080845 49.47 µM -1.10508323506422 0.178119847073628 no 2811 0.134561762136576 4244 5296973 SGTC_2670 beta-carotene 100 µM -1.10609660332719 0.177898107299341 no 2812 0.134342354376495 4140 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3071 9117417 49.47 µM -1.10795251295512 0.177492458782775 no 2813 0.133941162409556 4157 45595590 YGL055W OLE1 SGTC_1492 4158-0558 28.5 µM -1.10828394572054 0.177420078594478 no 2814 0.133869603327385 4204 3967268 SGTC_2080 5212524 12.4 µM -1.11323922233548 0.1763401395875 no 2815 0.132802850760494 4130 260183 SGTC_135 0933-0004 26.348 µM -1.11331170629035 0.176324373566486 no 2816 0.132787290261888 4179 21230617 YGL099W LSG1 SGTC_2541 muurolladie-3-one 83.07 µM -1.11382253198124 0.176213288909927 no 2817 0.132677664322114 4197 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2338 7999974 200 µM -1.11508547255057 0.175938838783139 no 2818 0.132406898130373 4212 315925 SGTC_2326 6164455 177.58 µM -1.11534168967199 0.175883193181971 no 2819 0.132352013353747 4172 2888790 SGTC_714 4296-0578 26.1 µM -1.11656143858882 0.175618439226007 no 2820 0.132090943542936 4242 1589775 SGTC_1253 0550-0034 176 µM -1.11768341378493 0.175375130758836 no 2821 0.131851114535297 4239 5969915 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.11823941363196 0.175254637387202 no 2822 0.131732377575119 4209 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1323 1348-1351 11.2 µM -1.11912217180733 0.175063438536854 no 2823 0.131544011097759 4171 6989654 SGTC_2371 9071574 200 µM -1.1193972701464 0.17500388133961 no 2824 0.131485347526846 4202 45596039 SGTC_3172 9105863 49.47 µM -1.12108724174075 0.174638294384758 no 2825 0.131125364407072 4270 2348785 SGTC_872 0588-0139 234 µM -1.12198353638973 0.174444598340816 no 2826 0.130934720015364 4173 2047100 SGTC_1125 tnp00248 1.32998 µM -1.1230264247749 0.174219394121359 no 2827 0.130713135915921 4286 24207736 SGTC_133 0724-0033 378.92 µM -1.12399620580539 0.174010142772613 no 2828 0.13050731778 4034 280309 SGTC_2507 purpurin 79.67 µM -1.12427024577649 0.173951041656715 no 2829 0.130449198486158 4221 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1056 3448-1962 115 µM -1.12528944309978 0.173731347429341 no 2830 0.130233200888088 4210 715507 SGTC_2662 daunorubicin 22.37 µM -1.12735199509775 0.173287292006763 no 2831 0.12979684347501 4095 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_425 3825-7017 13.1 µM -1.1275076558695 0.173253808503557 no 2832 0.1297639527218 4263 3397440 SGTC_2965 9082772 38.63 µM -1.12845831923487 0.173049404913083 no 2833 0.129563205063664 4241 16459634 SGTC_327 1273-0057 3.96 µM -1.12902986134733 0.172926590738324 no 2834 0.129442618480431 4101 3108138 SGTC_3223 9129970 49.47 µM -1.12922982982178 0.172883634209047 no 2835 0.12940044658182 4235 17248386 SGTC_1333 1482-0047 286 µM -1.13135636965695 0.172427239070289 no 2836 0.128952563723754 4233 3811116 SGTC_2164 5685496 200 µM -1.13606054191098 0.171420369053116 no 2837 0.127965613697657 4154 759046 SGTC_3327 9140648 26.9345 µM -1.13807293232949 0.170990791701735 no 2838 0.127545014779439 4251 8029710 SGTC_1502 4534-4282 27.7 µM -1.13943502349214 0.170700422421394 no 2839 0.127260877472623 4179 3278949 SGTC_1208 2323-2347 50.3 µM -1.13999506280298 0.170581125400246 no 2840 0.127144179022293 4227 5412760 SGTC_1140 3229-1848 2.98 µM -1.14125640853579 0.170312634832151 no 2841 0.126881618287943 4255 2849525 SGTC_560 2332-1943 155 µM -1.1414298840782 0.170275729944935 no 2842 0.126845537302705 4204 21177716 SGTC_803 4488-1585 147 µM -1.14483468834936 0.169552434980992 no 2843 0.126138821479842 4221 747204 SGTC_2121 5257820 149.641 µM -1.14623270775299 0.169256020330659 no 2844 0.125849438914624 4291 791256 SGTC_916 4466-0038 42 nM -1.14639620762809 0.169221376058936 no 2845 0.125815625578804 4291 5722064 YGL116W CDC20 SGTC_2411 st077133 39.94 µM -1.1494172254731 0.168582066684078 no 2846 0.125191990267186 4279 1403142 YNL221C POP1 SGTC_1798 st045719 60.953 µM -1.14999995109987 0.168458928844437 no 2847 0.125071945707461 4176 3980186 SGTC_763 3453-1109 128 µM -1.1523153632989 0.167970222416924 no 2848 0.12459575302378 4255 1560353 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.15292961201267 0.167840728268115 no 2849 0.124469638288527 4226 803109 SGTC_2741 miltefosine 3.04 µM -1.15385429309223 0.167645910898215 no 2850 0.124279955360242 4256 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_500 h-89 112 µM -1.15611050179863 0.167171170773955 no 2851 0.123817980493565 4251 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2516 gossypol 71.55 µM -1.15620382004169 0.16715155389979 no 2852 0.123798898838676 4270 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_779 1360-0071 233 µM -1.15779105535105 0.166818120885107 no 2853 0.123474657228105 4294 7566 SGTC_2220 6782180 200 µM -1.15877585492141 0.166611458352781 no 2854 0.123273780919617 4165 833803 SGTC_1860 st056228 74.6 µM -1.16048826216484 0.166252499264029 no 2855 0.122925034991446 4230 688679 SGTC_906 1165-0455 526 µM -1.16116709757217 0.166110338444142 no 2856 0.122786976186673 4235 3252859 SGTC_3091 9116372 49.47 µM -1.16197771046206 0.165940683870409 no 2857 0.122622259513244 4313 17169793 SGTC_3007 9078383 71.4286 µM -1.1628650534477 0.165755098753032 no 2858 0.122442129059428 4233 6496995 SGTC_985 1493-0307 8.71 µM -1.16450666202767 0.165412115158477 no 2859 0.122109372556402 4267 3278274 SGTC_2126 5251174 33.877 µM -1.16591504511865 0.165118225897208 no 2860 0.121824397712008 4261 790722 SGTC_1368 1852-0141 284 µM -1.16881667076638 0.164513805887226 no 2861 0.121238751134251 4263 2838987 SGTC_75 0159-0059 199.013 µM -1.17118941224218 0.164020621622068 no 2862 0.120761325073551 4333 5377270 SGTC_719 2810-4230 27.3 µM -1.17209041619006 0.163833595703439 no 2863 0.120580378633821 4263 721079 SGTC_2457 5731572 11.68 µM -1.17395551021567 0.163446888721821 no 2864 0.120206423124286 4308 2865357 SGTC_2045 5106652 78.05 µM -1.17667539326782 0.16288401407809 no 2865 0.119662546437952 4243 673349 SGTC_38 0929-0051 58.268 µM -1.17718251469613 0.162779205834424 no 2866 0.119561333047174 4253 1379719 SGTC_1635 st007035 42.4 µM -1.17744636273142 0.162724692952461 no 2867 0.119508697055525 4238 3716403 SGTC_565 1418-0001 44.5 µM -1.17924878475011 0.162352617397004 no 2868 0.119149562680381 4324 2862145 SGTC_3193 9111931 49.47 µM -1.18015047293041 0.162166689092736 no 2869 0.118970186595412 4279 17087244 SGTC_1590 st077108 57.8 µM -1.18415530810103 0.161342567344152 no 2870 0.118175794861758 4286 5489485 SGTC_623 k072-0108 16.9 µM -1.18435798796669 0.16130093228489 no 2871 0.118135691615662 4242 5382803 SGTC_723 4182-0001 115 µM -1.18455385170442 0.161260704072596 no 2872 0.118096946187875 4282 744821 YLR208W SEC13 SGTC_1602 st001878 87.6 µM -1.18523978011862 0.161119873676942 no 2873 0.117961327862084 4260 595405 YLR310C CDC25 SGTC_2558 carylophyllene oxide 100 µM -1.18617615820992 0.160927752161364 no 2874 0.117776369796629 4397 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1296 1068-0102 11.9 µM -1.18649755384596 0.160861844249215 no 2875 0.117712933463452 4261 767053 SGTC_27 0485-0001 32.618 µM -1.18712282049099 0.160733672659095 no 2876 0.117589589062046 4241 2054479 SGTC_3243 9134147 49.47 µM -1.18859202949067 0.160432766303404 no 2877 0.117300122927169 4381 24282180 SGTC_1909 st060837 51.5 µM -1.19201887326251 0.159732351274137 no 2878 0.116626922517836 4248 678937 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.19213028649086 0.159709613077179 no 2879 0.11660508156819 4279 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1219 1469-0211 33.1 µM -1.19259689992203 0.159614405492443 no 2880 0.116513640276473 4297 6822282 SGTC_3258 9138477 49.47 µM -1.19309572134027 0.159512667291601 no 2881 0.116415943509883 4301 4970355 SGTC_3097 9117246 49.47 µM -1.19325358005479 0.159480479720279 no 2882 0.116385038168947 4290 16423892 SGTC_2239 6685329 187.64 µM -1.19359799877466 0.159410267110998 no 2883 0.116317628596143 4311 805680 SGTC_162 k030-0015 37.8 µM -1.1964684385936 0.158825891482362 no 2884 0.11575690394847 4354 1809920 YMR134W ERG29 SGTC_1 0258-0098 57.368 µM -1.19935580754938 0.158239487742683 no 2885 0.115194811766602 4232 6790032 YDR047W HEM12 SGTC_2894 9048625 32.47 µM -1.19998754516923 0.15811137607677 no 2886 0.115072088794235 4307 4092861 SGTC_2916 7875993 68.79 µM -1.20122865370078 0.157859886856838 no 2887 0.114831258664953 4117 1299250 SGTC_2058 5236698 133 µM -1.20176378001167 0.1577515338414 no 2888 0.114727531119463 4250 766665 SGTC_1971 st069429 63.5 µM -1.20192701255806 0.157718492045783 no 2889 0.114695903804712 4287 1246522 YGL099W LSG1 SGTC_1345 1488-0192 31.4 µM -1.20239066028163 0.157624664522126 no 2890 0.114606103031628 4342 658348 SGTC_134 0269-0018 6.916 µM -1.20245833671213 0.15761097203711 no 2891 0.114592999430303 4253 4378915 SGTC_2704 st078022 71.1 µM -1.20412134612435 0.157274752863877 no 2892 0.114271340283 4323 54697681 SGTC_1168 k815-0004 80.5 µM -1.20414045852291 0.157270891554701 no 2893 0.114267647305234 4262 642433 SGTC_1796 st049173 110.4 µM -1.20426107707668 0.157246524228674 no 2894 0.114244342843324 4251 94134 SGTC_3151 9099821 49.47 µM -1.20441010999874 0.157216420068548 no 2895 0.114215553174793 4237 17174189 SGTC_1709 st033179 39.1045 µM -1.20467505444485 0.157162911519113 no 2896 0.114164384873824 4280 573381 SGTC_51 1013-0126 23.419 µM -1.20468003398292 0.157161905959337 no 2897 0.114163423339865 4308 1627850 SGTC_2228 7354201 200 µM -1.20486401626361 0.157124755844415 no 2898 0.114127900953359 4360 753451 SGTC_880 0833-0487 87.2 µM -1.20539505080255 0.157017560552322 no 2899 0.114025415595316 4290 76075 SGTC_128 0906-2981 13.371 µM -1.2072612368388 0.156641231580179 no 2900 0.113665776932896 4284 6740226 SGTC_3111 9122088 49.47 µM -1.20936601893049 0.156217501140686 no 2901 0.113261128808253 4147 16876704 SGTC_661 1304-0007 33.6 µM -1.21264260342091 0.155559370023013 no 2902 0.112633246463633 4293 3117130 SGTC_971 1315-0384 26.7 µM -1.21400167925802 0.155286924996581 no 2903 0.112373541453625 4322 6769120 SGTC_2439 5492030 7.2 µM -1.21688950941159 0.154709066753208 no 2904 0.111823128774006 4298 5722370 SGTC_2570 licareol 100 µM -1.21739302407626 0.154608458521758 no 2905 0.111727357970114 4276 443158 SGTC_746 1095-0025 46.6 µM -1.21956443063927 0.154175081012879 no 2906 0.111315018577064 4315 6749286 SGTC_3310 9130229 44.1445 µM -1.22188797211721 0.153712230603224 no 2907 0.110874997271468 4324 7761258 SGTC_2256 7954252 200 µM -1.22764040526885 0.152570305272208 no 2908 0.109790993459701 4306 2972920 SGTC_2652 actinonin 100 µM -1.22963646154218 0.152175383501614 no 2909 0.109416634919851 4341 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.23008629834549 0.152086476635177 no 2910 0.109332395176443 4377 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1300 1094-0077 113 µM -1.23179161121221 0.151749747668895 no 2911 0.109013468874898 4279 5532636 SGTC_2252 omeprazole 400 µM -1.23285298769739 0.151540419911414 no 2912 0.108815308974631 4308 4594 A proton pump inhibitor. SGTC_1369 1866-0067 208 µM -1.23379380043801 0.151355030655722 no 2913 0.108639875079117 4332 3531355 SGTC_3108 9121785 49.47 µM -1.23666913544996 0.150789374717866 no 2914 0.108104970844283 4136 17140271 SGTC_1476 4112-3294 3.34 µM -1.2426611470159 0.14961511246751 no 2915 0.106996363464254 4312 704369 SGTC_917 harmaline 728.087 nM -1.24698789598967 0.148770997679578 no 2916 0.106200967884539 4266 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3118 9124250 49.47 µM -1.24702991096332 0.14876281652268 no 2917 0.1061932651767 4277 1504786 SGTC_2877 9040724 71.43 µM -1.24802755906056 0.148568642794586 no 2918 0.106010482456944 4303 6463895 SGTC_605 1315-0399 119 µM -1.24880196634856 0.14841803562769 no 2919 0.105868757292862 4393 24020461 SGTC_1856 st057054 55.7 µM -1.25073696022817 0.14804216337901 no 2920 0.105515230547487 4332 1266018 SGTC_1603 st002045 67.8 µM -1.25364098009365 0.147479254512066 no 2921 0.104986264485625 4333 5887985 SGTC_2944 9067346 25.62 µM -1.25378245598003 0.147451867817125 no 2922 0.104960543834382 4275 6473075 SGTC_998 3996-0085 177 µM -1.25538358004029 0.147142162075435 no 2923 0.104669773579626 4352 715391 SGTC_3262 9137218 49.47 µM -1.25781254757571 0.146673159603239 no 2924 0.104229778376151 4266 17650664 SGTC_3176 9106582 49.47 µM -1.26012249611175 0.146228069745249 no 2925 0.103812588060211 4315 17018027 SGTC_2938 9059746 27.26 µM -1.26087900789337 0.146082499504356 no 2926 0.103676221232817 4332 6471769 SGTC_1402 3909-7673 35.9 µM -1.26208370504434 0.145850889114768 no 2927 0.103459334036979 4353 5328014 SGTC_1741 st038134 10.228 µM -1.26798046347224 0.144720763099261 no 2928 0.102402463698121 4395 1272587 SGTC_1209 2323-2347 50.3 µM -1.26836280726421 0.144647690273096 no 2929 0.102334208608468 4339 5412760 SGTC_2653 dihydrofissinolide 100 µM -1.26881457859952 0.144561380623351 no 2930 0.102253602132559 4384 6857746 SGTC_1102 cgs 12066b 26.1 µM -1.26893836935817 0.144537736802621 no 2931 0.102231523055423 4347 6438352 A 5-HT1B full agonist. SGTC_1791 st048313 56.1 µM -1.27252901585003 0.143853063269716 no 2932 0.101592610700738 4357 1204976 SGTC_1480 1070-0044 41.2 µM -1.27272130132943 0.143816459614308 no 2933 0.101558478023227 4369 3124987 SGTC_2040 5100729 123 µM -1.2728775421626 0.143786722081315 no 2934 0.101530749796698 4363 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3264 9137442 49.47 µM -1.27450888094719 0.143476474928666 no 2935 0.101241563636363 4329 17015726 SGTC_2163 5671233 125 µM -1.27687059579725 0.143028126494212 no 2936 0.100823968360531 4318 701023 SGTC_1647 st011722 22.4 µM -1.27904059231654 0.142617009247443 no 2937 0.100441380937783 4314 2854783 SGTC_3183 9108214 49.47 µM -1.28093943749137 0.142257919193516 no 2938 0.100107469593582 4321 4974831 SGTC_1888 azatryptophan 97.5 µM -1.2862052008928 0.141265315094366 no 2939 0.0991857282228601 4399 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_368 fentichlor 4.58 µM -1.28634837310533 0.141238392648318 no 2940 0.0991607537137258 4366 7329 A pesticide. SGTC_2101 5377231 179.231 µM -1.28853790115975 0.140827101895011 no 2941 0.0987793921231138 4387 2844213 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.29421350616065 0.139764757042808 no 2942 0.0977958414068132 4386 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1429 4049-0205 9.46 µM -1.29497698129973 0.139622268586468 no 2943 0.097664085157024 4394 22774478 SGTC_2264 7948757 110.76 µM -1.29590021146733 0.139450096809551 no 2944 0.0975049331945215 4313 2971411 SGTC_1774 st048371 48.465 µM -1.29677670481993 0.139286774597576 no 2945 0.0973540140978106 4341 4242727 SGTC_709 3807-1509 243 µM -1.30052597402499 0.13858962046518 no 2946 0.096710379970407 4430 1886677 YPL242C IQG1 SGTC_2385 9074692 200 µM -1.30061287219301 0.138573490510444 no 2947 0.0966954993755508 4382 17046906 SGTC_1969 st069479 40.1 µM -1.3020776409188 0.138301794027194 no 2948 0.0964449228329733 4373 3895485 SGTC_1615 st002656 86.5 µM -1.3029113723645 0.138147309429991 no 2949 0.0963025104634266 4372 1584458 SGTC_660 4031-1742 102 µM -1.30841258326817 0.13713092356349 no 2950 0.0953667034559714 4263 6738706 SGTC_1693 xanthone 101.9 µM -1.31027920159642 0.136787216916364 no 2951 0.095050700385687 4408 7020 An insecticide. SGTC_156 3474-0145 5.642 µM -1.31158501705312 0.136547123141746 no 2952 0.0948300955525001 4285 2265471 SGTC_1254 0550-0035 264 µM -1.31260970207429 0.13635892134883 no 2953 0.0946572493310564 4381 15121435 SGTC_1156 4092-0367 4.88 µM -1.31538632747678 0.13584983654015 no 2954 0.0941900491149271 4424 1357585 SGTC_885 0865-0106 16.8 µM -1.31678701253871 0.135593520206375 no 2955 0.0939550137031924 4331 2793380 SGTC_1432 4049-0298 68.4 µM -1.31848952680538 0.135282417443812 no 2956 0.0936699143666882 4395 741646 SGTC_570 0987-0065 62.6 µM -1.3185474299823 0.13527184532772 no 2957 0.093660229270484 4220 3104428 SGTC_2682 pyrogallin 40.03 µM -1.32002893915303 0.135001540062425 no 2958 0.0934126780691463 4396 822798 An ATP competetive kinase inhibitor. SGTC_591 4299-0174 154 µM -1.32138530223166 0.134754393077401 no 2959 0.0931864621213474 4415 5509088 SGTC_808 0711-0032 135 µM -1.32902941423865 0.133367342971827 no 2960 0.0919191328935659 4362 4252555 SGTC_697 0508-1955 564 µM -1.32945348745706 0.13329068204925 no 2961 0.0918492006950201 4381 6243113 SGTC_1643 st009866 20.2 µM -1.33048363113652 0.133104586338669 no 2962 0.0916794880162076 4359 3156273 YOR207C RET1 SGTC_2644 guaiazulene 100 µM -1.33284202814162 0.132679214913067 no 2963 0.0912918251221579 4403 3515 A coloring agent. SGTC_1007 4101-0031 70 µM -1.33829304036455 0.131699631146519 no 2964 0.0904004648271577 4381 1146276 SGTC_2964 9083345 53.42 µM -1.33981053222739 0.131427817906738 no 2965 0.0901534753185624 4368 17741579 SGTC_1553 gossypol 38.6 µM -1.34085999423558 0.131240064900113 no 2966 0.0899829565904295 4296 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2898 9056270 58.44 µM -1.34131467841965 0.131158777597451 no 2967 0.0899091530333877 4395 19154699 SGTC_925 2064-1272 59.6 µM -1.34188616990973 0.131056657110675 no 2968 0.0898164533347852 4360 6815817 SGTC_85 0868-0259 160.055 µM -1.34402873357913 0.130674288969071 no 2969 0.0894695477582232 4325 83173 SGTC_2402 5553605 200 µM -1.34458252640351 0.130575583054516 no 2970 0.089380044653234 4463 6758546 SGTC_2314 7727897 200 µM -1.34604895647341 0.130314461214495 no 2971 0.0891433642978074 4372 900724 SGTC_1292 0kpi-0043 232 µM -1.34902468806414 0.129785694443559 no 2972 0.0886645182105921 4425 3333905 SGTC_363 0455-0021 3.06 µM -1.34990049460068 0.1296303531008 no 2973 0.0885239515163597 4349 4597466 SGTC_1169 aniline yellow 25.8 µM -1.35061750878028 0.129503272588765 no 2974 0.0884089946002904 4331 6051 A DNA damaging agent. SGTC_1652 st011932 78 µM -1.35297295679847 0.129086410723799 no 2975 0.0880321349973893 4335 1551076 SGTC_2619 obliquin 87.91 µM -1.35425709741693 0.128859538710344 no 2976 0.0878271842492369 4360 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2795 7780010 54.55 µM -1.35461245125616 0.12879680643474 no 2977 0.0877705321685545 4364 953673 SGTC_64 000l-0018 272.079 µM -1.35755269563069 0.128278564174117 no 2978 0.0873028309016787 4328 6811119 SGTC_2596 sinensetin 100 µM -1.35780531293445 0.1282341059384 no 2979 0.08726273432184 4416 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2928 9011484 9.79 µM -1.35817500110574 0.128169063635562 no 2980 0.0872040805016519 4400 2994751 SGTC_2181 6316240 54.2555 µM -1.36090582867613 0.127689316242195 no 2981 0.0867717256607271 4409 12779990 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.3637406519971 0.127192621004695 no 2982 0.0863246023849228 4436 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2273 7815444 169.05 µM -1.36427083097178 0.127099876668129 no 2983 0.0862411713565434 4352 2824616 SGTC_553 k007-0256 45.7 µM -1.36496844270463 0.126977914990856 no 2984 0.086131484362714 4469 6287000 SGTC_923 1900-2434 73.3 µM -1.36586605329699 0.126821107889945 no 2985 0.0859905046919924 4387 5910570 SGTC_1193 1488-0126 41.5 µM -1.36825893396752 0.126403745149226 no 2986 0.0856155200899343 4381 1384710 SGTC_173 1273-0061 2.693 µM -1.36967095572322 0.126157911842732 no 2987 0.0853948195289829 4375 2847414 YPL266W DIM1 SGTC_1680 diphenhydramine 100 µM -1.3725566840179 0.125656542903388 no 2988 0.0849451028386265 4379 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_435 c-PAF 6.7 µM -1.3749750206596 0.125237450978377 no 2989 0.0845695945219787 4366 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2789 5281112 71.43 µM -1.37643340392304 0.124985188914318 no 2990 0.0843437460597271 4416 765948 SGTC_2130 NSC 7 2.4545 µM -1.37674843625045 0.124930743232875 no 2991 0.0842950189545301 4468 21448 SGTC_2978 9011784 42.97 µM -1.37750212478542 0.124800553732129 no 2992 0.0841785291600706 4403 2994934 SGTC_2780 5215298 71.43 µM -1.3776611419057 0.124773097790735 no 2993 0.0841539669825498 4438 2834131 SGTC_2950 9072895 21.46 µM -1.37796786237008 0.124720151271337 no 2994 0.0841066053783503 4382 17332245 SGTC_3339 9145883 14.936 µM -1.37855456606474 0.124618917400027 no 2995 0.0840160664952762 4342 2030670 SGTC_3153 9100258 49.47 µM -1.37870065401655 0.124593719318863 no 2996 0.0839935338924692 4343 25236848 SGTC_929 2805-0021 398 µM -1.38334707448832 0.123794135844199 no 2997 0.0832792351817549 4466 3098024 SGTC_3143 9086658 49.47 µM -1.38456197318787 0.123585662629649 no 2998 0.0830932229491016 4425 25236626 SGTC_3105 9121040 49.47 µM -1.38479916961786 0.123544989090371 no 2999 0.0830569424659325 4368 41448907 SGTC_3202 9113761 49.47 µM -1.386441392335 0.123263644148817 no 3000 0.0828060822921919 4348 4798415 SGTC_2821 7996764 71.43 µM -1.38879669828867 0.1228609182469 no 3001 0.0824472897703234 4434 2987135 SGTC_730 1436-0052 41.2 µM -1.38999087485576 0.122657082856896 no 3002 0.0822658241644096 4469 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2258 7960471 200 µM -1.39039382597936 0.12258835621927 no 3003 0.0822046601289596 4424 2974708 SGTC_2934 9036370 36.88 µM -1.39119902810936 0.122451103298238 no 3004 0.0820825409456356 4397 6462800 SGTC_1558 st069300 45.6 µM -1.39151242490208 0.122397711560182 no 3005 0.0820350472875644 4374 24208000 SGTC_345 1362-0200 395 µM -1.4040785321051 0.120270339904069 no 3006 0.0801477327714733 4424 1419823 SGTC_1023 4482-3888 16 µM -1.40602025457611 0.11994395498344 no 3007 0.0798590551840913 4443 3303168 SGTC_3023 9089636 49.47 µM -1.40881216925856 0.119475755995405 no 3008 0.0794453579059587 4524 17249241 SGTC_497 capsazepine 133 µM -1.40989613361473 0.119294325096152 no 3009 0.0792851772540576 4389 2733484 A calcium channel blocker. SGTC_983 1491-0821 12.2 µM -1.4132754497355 0.118729952971382 no 3010 0.0787873747837717 4432 46495113 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.41486571135696 0.118465020581816 no 3011 0.0785539365328267 4438 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2818 7996756 12.99 µM -1.41780249255791 0.117976861307529 no 3012 0.0781242181308262 4461 2241621 SGTC_1835 st008666 49.2 µM -1.41890963767247 0.117793198678918 no 3013 0.0779626810745465 4393 690455 SGTC_2166 5933061 31.504 µM -1.42102185185469 0.117443368075405 no 3014 0.0776552034406556 4497 2877375 SGTC_2377 9073351 62.6 µM -1.42603547831971 0.116615945000986 no 3015 0.0769290506927852 4443 7337946 YHR072W ERG7 SGTC_3152 9099253 49.47 µM -1.42655801219471 0.1165299471695 no 3016 0.076853667066751 4321 25236131 SGTC_3232 9132874 49.47 µM -1.4314836105101 0.115721509521397 no 3017 0.0761458304411996 4418 3784940 SGTC_1286 0929-0070 131 µM -1.43465734945324 0.115202719213372 no 3018 0.075692381779784 4521 1420408 SGTC_2746 daunorubicin 9.88 µM -1.43470338032859 0.115195207031952 no 3019 0.0756858202749849 4466 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1391 3442-0225 151 µM -1.43628727931314 0.114936928824987 no 3020 0.0754603061141055 4430 5227075 SGTC_2206 7254556 146.969 µM -1.4365570524387 0.114892979400402 no 3021 0.0754219471409599 4495 4398905 SGTC_855 0428-0020 25 µM -1.43767610107678 0.114710799986182 no 3022 0.0752629885605343 4475 6812414 SGTC_2593 nobiletin 86.24 µM -1.43799387658332 0.114659104109523 no 3023 0.0752178957905488 4436 72344 An anti-infammatory. SGTC_2988 9073640 71.4286 µM -1.44605260120398 0.113353644284196 no 3024 0.0740812243696015 4484 9102229 SGTC_2327 6189656 200 µM -1.45214774883338 0.112373336953673 no 3025 0.0732302638166288 4527 5349088 SGTC_2844 9010103 25.97 µM -1.45598812599326 0.111758792701242 no 3026 0.072697951047899 4446 2480525 SGTC_63 0099-0242 26.702 µM -1.45779938109711 0.111469788052613 no 3027 0.0724479244691595 4485 3898502 YLR359W ADE13 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.45925797264925 0.111237443631324 no 3028 0.0722470590404622 4472 688798 SGTC_2861 9024595 19.48 µM -1.45965544012823 0.111174189730211 no 3029 0.0721923971015457 4394 16482810 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.46936148817963 0.109637532928515 no 3030 0.0708673836105566 4553 4620898 SGTC_1206 3978-0017 132 µM -1.46949750551314 0.109616107624615 no 3031 0.0708489489563419 4516 3873677 SGTC_3141 9094609 49.47 µM -1.4702869904138 0.109491808175909 no 3032 0.0707420215033651 4445 25236309 YDL196W YDL196W SGTC_2491 paeonol 100 µM -1.47280437382298 0.109096137996817 no 3033 0.0704018963191795 4446 11092 Increases levels of cortical cytochrome oxidase. SGTC_588 3970-1144 52.9 µM -1.47735363275676 0.108383715811257 no 3034 0.0697904341578451 4381 1888707 SGTC_2324 6149169 200 µM -1.47882810846018 0.108153530164927 no 3035 0.0695931306852403 4422 2888231 SGTC_1435 4092-0789 56.7 µM -1.47958648055134 0.108035275142516 no 3036 0.0694918183132644 4480 2248285 SGTC_3177 9107506 49.47 µM -1.48075732109415 0.10785288565752 no 3037 0.0693356265835324 4445 8897194 SGTC_1509 1326-1131 80 µM -1.48133426814749 0.107763092454049 no 3038 0.0692587605824038 4464 768313 SGTC_2226 7298446 200 µM -1.49055497875008 0.106335328180229 no 3039 0.0680391859441539 4496 3283010 SGTC_155 k072-0202 43.6 µM -1.49179536811788 0.1061443096786 no 3040 0.0678763992918496 4471 5857737 SGTC_1405 3909-7894 12 µM -1.49195787836098 0.106119301670352 no 3041 0.0678550940194439 4482 7104060 SGTC_1903 st060211 78.3 µM -1.49323601792717 0.105922762603996 no 3042 0.0676877085151181 4518 688960 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.49623604267706 0.105462483533325 no 3043 0.0672960776023948 4535 1609 A potent and irreversible inhibitor of serine proteases. SGTC_122 0236-0016 402.397 µM -1.4976886320912 0.105240140397169 no 3044 0.0671070833693255 4492 6808838 SGTC_1088 bifonazole 369 nM -1.50191004362204 0.104595908216658 no 3045 0.0665601712092501 4490 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_818 4072-2707 53.5 µM -1.50294920363645 0.104437760461921 no 3046 0.0664260717009359 4425 882871 SGTC_1837 st055472 66.5 µM -1.51341731700098 0.102854294401755 no 3047 0.0650868445060128 4548 676091 SGTC_1393 3470-5649 58.2 µM -1.52062845689204 0.101773690691607 no 3048 0.0641765507255662 4502 4108395 SGTC_1124 fisetin 1.16336 µM -1.52452147373299 0.101193761017321 no 3049 0.0636892484057948 4522 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_563 tetrahydrosecaminediol 614 µM -1.53093451840957 0.100243688350871 no 3050 0.0628927885212716 4554 334274 A psychoactive constituent of the cannabis plant. SGTC_1973 st070275 50.2 µM -1.53454204930517 0.0997121136751824 no 3051 0.062448178416106 4491 17118334 SGTC_2921 7974240 10.71 µM -1.53547350948652 0.099575196855836 no 3052 0.0623337796244156 4568 2979074 YDR527W RBA50 SGTC_3188 9110789 49.47 µM -1.53695650163442 0.0993574930529376 no 3053 0.0621519808633055 4481 849217 SGTC_457 grayanotoxin iii 135 µM -1.54023029415942 0.0988781314323153 no 3054 0.0617521140036732 4325 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2823 7987624 58.44 µM -1.54064013217194 0.0988182407148404 no 3055 0.0617021974270898 4458 2239440 SGTC_111 0083-0039 52.457 µM -1.54301302536186 0.0984720052310029 no 3056 0.0614138078006947 4489 759313 SGTC_1465 k213-0056 144 µM -1.54426488262351 0.0982897015411553 no 3057 0.0612620881394807 4431 24048857 YMR208W ERG12 SGTC_2262 9014885 67.46 µM -1.54845564558426 0.0976812140676535 no 3058 0.0607563163599919 4555 6457424 SGTC_2393 9031399 185.94 µM -1.55138617760989 0.0972573527387385 no 3059 0.0604045828493942 4507 1526623 YDL150W RPC53 SGTC_960 1222-0186 7.7 µM -1.55441442158819 0.0968207781016228 no 3060 0.0600427977015952 4515 3126296 SGTC_1510 1123-0200 71.5 µM -1.56259455818398 0.0956486644165408 no 3061 0.0590739945391578 4530 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1224 0823-0416 294 µM -1.56279783352549 0.095619671080345 no 3062 0.0590500769726055 4553 3598164 SGTC_1843 st055809 45.5 µM -1.56773319226099 0.0949177199431244 no 3063 0.0584717059809416 4561 16413835 SGTC_183 3914-0051 30.55 µM -1.56779334371529 0.0949091881423425 no 3064 0.0584646844150489 4521 1596232 SGTC_874 0599-0792 117 µM -1.56936146049428 0.0946869679013116 no 3065 0.0582818694067824 4529 765305 SGTC_963 1269-2853 151 µM -1.57469168369221 0.0939344810300644 no 3066 0.0576638141727832 4528 3668223 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.57496099715751 0.0938965785388473 no 3067 0.0576327237920641 4611 688801 SGTC_987 1497-1013 404 µM -1.57678351722041 0.0936403783207289 no 3068 0.0574226727709538 4551 1676435 SGTC_1979 st071809 45.3 µM -1.58068219605244 0.0930940564570287 no 3069 0.0569753606047134 4572 4976333 SGTC_780 0109-0199 192 µM -1.58115879416004 0.093027432690926 no 3070 0.0569208671678935 4564 610414 SGTC_1557 sumaresinolic acid 42.3 µM -1.58336184088234 0.0927199261911049 no 3071 0.0566695075964098 4510 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1281 0884-0031 11.8 µM -1.58496638913847 0.0924964331349897 no 3072 0.0564869855089857 4545 1548255 SGTC_1967 st070177 51.4 µM -1.58761719361535 0.0921280834953684 no 3073 0.0561864639376696 4546 5729214 SGTC_3302 9125395 16.351 µM -1.58886716177868 0.0919547680711836 no 3074 0.0560451931795958 4499 17599668 SGTC_1499 4480-0877 67.3 µM -1.58936995924688 0.0918851203885922 no 3075 0.0559884463366178 4536 2861909 SGTC_2913 7966556 36.57 µM -1.58950179047362 0.0918668655472332 no 3076 0.05597357507222 4441 2976516 SGTC_109 0132-0036 33.701 µM -1.59048329200558 0.0917310401933095 no 3077 0.055862954402136 4448 67274 A color developer. SGTC_936 3005-4620 401 µM -1.59196586687725 0.0915261558440925 no 3078 0.055696187105187 4549 777207 SGTC_475 α-linolenic acid 10 µM -1.59206297419293 0.0915127479478764 no 3079 0.0556852777224114 4536 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1115 galangin 695.678 nM -1.59549364417299 0.0910399987954515 no 3080 0.0553009450841044 4604 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3046 9092212 49.47 µM -1.59713046229628 0.0908150832583314 no 3081 0.0551183145776158 4613 25236637 SGTC_1371 2421-0008 32.7 µM -1.60234883109288 0.0901007788043445 no 3082 0.0545392465812614 4542 2827552 SGTC_117 lucigenin 22.078 µM -1.60379161763441 0.0899040248049389 no 3083 0.0543799964447291 4515 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1069 diphenylcyclopropenone 8.49 µM -1.60488499294095 0.0897551331213708 no 3084 0.0542595583784053 4580 65057 A dermal irritant. YDR527W RBA50 SGTC_459 nigericin 15.3 µM -1.61451803097103 0.0884512565661602 no 3085 0.0532075545097712 4570 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3195 9113082 49.47 µM -1.61811113447299 0.0879685442370371 no 3086 0.0528193246787327 4537 17018038 SGTC_1872 amphotericin b 148 nM -1.61939112605805 0.0877970602897442 no 3087 0.0526815674740501 4558 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3189 9110682 49.47 µM -1.62242768459734 0.0873912419319095 no 3088 0.0523559027053002 4561 17122418 SGTC_3344 9148862 3.898 µM -1.62393166022879 0.0871907635842231 no 3089 0.0521951973176556 4582 4905352 SGTC_222 nsc-310342 10.666 µM -1.63780207801879 0.0853580140599546 no 3090 0.0507314939832236 4581 432556 SGTC_601 0986-0029 62.9 µM -1.64184378019755 0.0848294371429656 no 3091 0.0503111916847741 4528 24747981 SGTC_2225 6654152 15.4 µM -1.64846042047951 0.0839694111169937 no 3092 0.0496291131035327 4513 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2765 myclobutanil 7.74 µM -1.65003203467079 0.0837660994465268 no 3093 0.0494681920970365 4570 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_382 3229-0966 23.2 µM -1.65415642838799 0.083234306528138 no 3094 0.049047866631993 4589 5722370 SGTC_1612 st002233 45.4 µM -1.65615788852279 0.0829771579496574 no 3095 0.0488449243916708 4586 1035021 SGTC_1600 coumarin 106 71.1 µM -1.6689357418954 0.081349521414593 no 3096 0.04756505763212 4620 100336 A hepatotoxic, DNA x-linker. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.66904304561009 0.0813359558331748 no 3097 0.0475544246367403 4520 6708739 YPR165W RHO1 SGTC_1035 k081-0041 55.2 µM -1.6719475539729 0.0809694091456123 no 3098 0.0472673322010259 4591 731709 SGTC_2017 5132927 60.65 µM -1.67807438862488 0.0802002985476908 no 3099 0.0466662889244289 4551 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_479 n-linoleoylglycine 10 µM -1.68606437653526 0.0792056157455275 no 3100 0.0458917002431636 4620 6433346 An anti-infammatory. SGTC_862 0452-0056 10.2 µM -1.69065374439956 0.0786385190204423 no 3101 0.0454514767637728 4544 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1817 st052116 64.4 µM -1.69203483897323 0.0784684644063759 no 3102 0.0453196655775409 4608 4361398 SGTC_2 0422-0095 29 µM -1.69206631114369 0.0784645924794659 no 3103 0.0453166654716936 4518 6790840 SGTC_1786 berberine 21.6 µM -1.69768164997046 0.0777760700215029 no 3104 0.0447839314754716 4493 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2656 pseudo-anisatin 100 µM -1.69781233110842 0.077760101386559 no 3105 0.0447715939022348 4655 6708809 A neurotoxin. SGTC_2436 5633522 8.09 µM -1.70015295749487 0.0774745088889945 no 3106 0.0445510791174826 4567 5724242 SGTC_429 1112-0049 25.5 µM -1.70033686914916 0.0774521026302983 no 3107 0.0445337895965873 4552 2836170 SGTC_567 1080-0542 68.4 µM -1.70044073697331 0.077439450417558 no 3108 0.0445240273789055 4495 5950415 SGTC_360 0957-0399 1.01 µM -1.70607051933905 0.0767560283726421 no 3109 0.0439974753357181 4599 6752301 YPR165W RHO1 SGTC_3001 9076041 71.4286 µM -1.71218672627215 0.0760187653739199 no 3110 0.0434311314091844 4590 16004211 SGTC_1407 3909-7909 12.3 µM -1.71273531136332 0.0759529019361146 no 3111 0.0433806228645557 4621 4411780 SGTC_249 wiskostatin 11.211 µM -1.7127796513768 0.0759475803474181 no 3112 0.0433765425263437 4568 2775510 A n-wasp and actin depolymerizer. SGTC_2908 7930301 100 µM -1.71293475270816 0.075928967667939 no 3113 0.0433622719442018 4549 2223178 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.71418488193077 0.0757790747741121 no 3114 0.0432473882603024 4577 6728940 SGTC_1418 3966-3099 2.4 µM -1.71727027361281 0.0754100950439699 no 3115 0.0429649004023746 4616 740335 SGTC_1451 4152-0210 104 µM -1.72022879962192 0.0750575746227786 no 3116 0.0426954299763023 4623 659563 SGTC_1650 st011916 45.8 µM -1.72087930831438 0.0749802326762219 no 3117 0.0426363635290003 4577 242528 SGTC_1736 st036774 51 µM -1.73013382796842 0.0738864942235573 no 3118 0.0418031837939572 4633 1272247 SGTC_1226 3909-7979 35.4 µM -1.73013939722996 0.0738858397152183 no 3119 0.0418026863947869 4582 6615510 SGTC_866 0495-0101 262 µM -1.73065043995801 0.0738258000279109 no 3120 0.0417570647894943 4599 635694 SGTC_2783 7738165 71.43 µM -1.73585435561627 0.0732165410439822 no 3121 0.0412947951188886 4581 17201110 SGTC_398 bronopol 33.3 µM -1.73819587988495 0.0729436604102047 no 3122 0.0410881524238406 4539 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_110 0850-0284 111.64 µM -1.74078532035651 0.072642794917089 no 3123 0.0408606080302471 4562 3906265 SGTC_2846 9008642 19.48 µM -1.7449798386938 0.0721574542829603 no 3124 0.040494189241224 4599 2992898 SGTC_2536 dehydroabietamide 32.04 µM -1.74668728926752 0.0719606013653312 no 3125 0.0403457982024255 4618 3983547 SGTC_2287 7945887 168.79 µM -1.74912016127382 0.0716808259125574 no 3126 0.0401351254503968 4623 1245853 SGTC_3162 9099653 49.47 µM -1.75460260538454 0.0710534153929037 no 3127 0.0396636527547201 4587 25237511 SGTC_3313 9133968 57.047 µM -1.75840234306726 0.0706210540693577 no 3128 0.0393395373749624 4596 1494643 SGTC_3268 9137683 49.47 µM -1.76422843901392 0.0699620500302014 no 3129 0.0388467632558921 4658 1953228 SGTC_964 1287-0107 19.4 µM -1.76955309395414 0.0693639130064126 no 3130 0.0384008093165647 4607 51516812 YPR165W RHO1 SGTC_206 4546-0025 72.014 µM -1.77150502924585 0.069145634645481 no 3131 0.0382383785525468 4624 6620745 YIL048W NEO1 SGTC_1793 st048256 72.231 µM -1.77319664062493 0.0689568958748564 no 3132 0.0380980642655854 4620 672022 SGTC_2055 5235184 200 µM -1.77667499240629 0.0685700525074155 no 3133 0.0378108645608744 4613 2836034 SGTC_2211 7117706 200 µM -1.77922725558472 0.0682872700086272 no 3134 0.0376012558063814 4592 822771 SGTC_23 0213-0011 39.996 µM -1.79689210589661 0.0663546696887715 no 3135 0.0361763750513395 4616 627608 SGTC_552 k242-0005 476 µM -1.79805237092146 0.0662292299619259 no 3136 0.0360843544853244 4663 4088318 SGTC_2912 7964298 10.93 µM -1.80111494755857 0.0658990078245197 no 3137 0.0358423821150498 4609 2975850 SGTC_3067 9117431 49.47 µM -1.80863030472899 0.0650940726942172 no 3138 0.0352542285904639 4630 17150885 SGTC_3024 9090631 49.47 µM -1.81733258329062 0.0641715684138575 no 3139 0.0345831018522949 4633 25236383 SGTC_2836 9010338 19.48 µM -1.81901407357019 0.0639944955579864 no 3140 0.0344546414937822 4574 2994051 SGTC_2943 9068529 45.32 µM -1.82164181209549 0.0637185371327234 no 3141 0.0342546761437578 4585 3270634 SGTC_1210 3013-0140 750 nM -1.8273309590954 0.0631242498845659 no 3142 0.0338250115346753 4654 905973 SGTC_83 0170-0301 39.027 µM -1.82940917526934 0.062908239396853 no 3143 0.0336691670630466 4659 3089716 SGTC_2493 resveratrol 26.09 µM -1.83641697465805 0.0621840893973279 no 3144 0.0331480054815221 4615 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1824 st053723 68.6 µM -1.83832405281961 0.0619881515976059 no 3145 0.0330073344273214 4642 675225 SGTC_1104 tacrolimus 29.8 µM -1.83834279357301 0.0619862285207243 no 3146 0.0330059545052079 4688 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2428 5615643 7.78 µM -1.84421843636994 0.0613855932549056 no 3147 0.0325756562870495 4642 2253075 SGTC_3267 9137951 49.47 µM -1.84465773682635 0.0613408692472326 no 3148 0.032543671219705 4663 16643986 SGTC_725 1497-0963 19 µM -1.84587234507926 0.0612173457098003 no 3149 0.0324553714978907 4682 3549977 SGTC_1838 st055369 84.5 µM -1.85266938863121 0.0605296821175617 no 3150 0.0319648800809655 4617 676036 SGTC_2545 solidagenone 89.61 µM -1.85404936181773 0.0603908097471702 no 3151 0.0318660491599986 4611 6708572 An anti ulcer agent SGTC_635 k038-0028 24.7 µM -1.86009661107427 0.0597851885257805 no 3152 0.031435929289371 4649 4035102 SGTC_995 3931-2021 34.6 µM -1.86366357554284 0.0594302006186975 no 3153 0.0311844817799626 4632 730143 SGTC_3319 9138450 16.7555 µM -1.86561948105328 0.0592362495477343 no 3154 0.0310473110452134 4606 2029690 SGTC_1274 0865-0114 173 µM -1.87652701586182 0.0581637266482593 no 3155 0.0302914742979669 4646 870624 SGTC_2118 5526350 200 µM -1.87830288255583 0.0579905614494105 no 3156 0.0301698712282197 4640 743594 SGTC_568 1193-0097 7.48 µM -1.87918174237831 0.0579050136218178 no 3157 0.0301098408570088 4463 3646150 SGTC_1297 1068-0111 14.1 µM -1.88460421530193 0.0573793847538458 no 3158 0.0297416463913305 4656 767057 SGTC_3063 1327-0034 4 µM -1.88464143641392 0.0573757897318874 no 3159 0.0297391319868316 4534 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2348 9022543 33.42 µM -1.88658847543002 0.0571879808575857 no 3160 0.0296078490215848 4661 3162678 YDL140C RPO21 SGTC_215 1287-0124 461.5 µM -1.88671530005034 0.0571757643228283 no 3161 0.0295993143320035 4700 5560863 SGTC_3012 9080433 71.4286 µM -1.89090996464997 0.0567728644498473 no 3162 0.0293181820164321 4648 17688859 SGTC_1143 3454-2408 5.08 µM -1.89136692614205 0.0567291084564265 no 3163 0.0292876902009027 4674 X1143 SGTC_208 k072-0098 12.366 µM -1.89367167920461 0.0565088233518677 no 3164 0.0291343013508004 4665 5948901 SGTC_1197 1601-0112 267 µM -1.90790416959428 0.0551634000828565 no 3165 0.0282018016419109 4640 7350313 SGTC_344 k064-0035 6.43 µM -1.90945923310077 0.0550179435734684 no 3166 0.0281014379529061 4600 5088750 SGTC_3249 9135183 49.47 µM -1.91150438739273 0.054827106842558 no 3167 0.027969896758369 4615 4902779 SGTC_3039 9090270 49.47 µM -1.92156246793084 0.0538961735918075 no 3168 0.027330417511245 4653 17173750 SGTC_2205 7238770 200 µM -1.92368087837073 0.0537017072303967 no 3169 0.0271972981450523 4686 279867 SGTC_2004 4023728 41.89 µM -1.93126160466448 0.0530103591086624 no 3170 0.0267253545078073 4614 360084 YDR527W RBA50 SGTC_3285 9112818 20.8695 µM -1.93219933601617 0.0529253325336246 no 3171 0.0266674535594083 4653 17017947 YPR165W RHO1 SGTC_384 k007-0144 5.16 µM -1.93653322612002 0.0525337716374841 no 3172 0.0264012136059329 4644 6824886 SGTC_2305 7443522 69.23 µM -1.93711714536356 0.0524811915763871 no 3173 0.0263655126202891 4582 5415886 SGTC_946 3434-1334 87.4 µM -1.94483652178801 0.0517900059002667 no 3174 0.0258973284853292 4644 4047976 SGTC_1929 genistein trimethyl ether 50.5 µM -1.94908326950285 0.0514128525874549 no 3175 0.025642740658613 4631 136420 SGTC_807 1315-0151 48 µM -1.95320857952067 0.0510485790292895 no 3176 0.0253974424374392 4664 4011080 SGTC_353 1988-1175 58.3 µM -1.96099012655212 0.0503670461201928 no 3177 0.024940087337405 4522 2788357 SGTC_443 clozapine 122 µM -1.96158161163956 0.0503155398963111 no 3178 0.0249056074269146 4667 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1225 1216-0074 20.6 µM -1.967445511128 0.0498071823977899 no 3179 0.0245659359521045 4673 4241466 SGTC_71 0417-1750 47.813 µM -1.97519600046211 0.0491415671104228 no 3180 0.0241229548148505 4628 6811472 SGTC_809 3998-0021 90 µM -1.97800321762478 0.0489022420264764 no 3181 0.0239641718367734 4652 715485 SGTC_2736 butenafine 14.65 µM -1.9824327991883 0.0485264998439963 no 3182 0.0237154108412803 4641 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3316 9136639 10.545 µM -1.98376671836662 0.0484138026361118 no 3183 0.0236409259728628 4689 4903665 SGTC_3055 9094636 49.47 µM -1.98439175244323 0.0483610682098693 no 3184 0.0236060923714335 4668 25236176 SGTC_989 1501-0895 10.3 µM -1.98620014816159 0.0482087517185142 no 3185 0.0235055522113771 4676 2830112 SGTC_1085 doxorubicin 7.67 µM -1.98764010990472 0.0480877421586507 no 3186 0.0234257534688243 4691 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1100 amiodarone 5.07 µM -1.99132388644843 0.0477792760743913 no 3187 0.0232226455274853 4690 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2564 betulinic acid 100 µM -1.99244753679101 0.0476855016586719 no 3188 0.0231609880089222 4642 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_193 1273-0060 1.558 µM -1.99435549694256 0.0475266102189617 no 3189 0.0230566091576436 4578 2847393 YHR072W ERG7 SGTC_1404 3909-7820 48.3 µM -1.99663807329058 0.04733707894451 no 3190 0.022932256882588 4671 23741373 SGTC_3136 9095672 49.47 µM -2.00046228651233 0.0470208974310735 no 3191 0.0227251841882515 4572 17217380 SGTC_1620 st003704 16.5 µM -2.00631802532311 0.0465400357925784 no 3192 0.0224111640348573 4695 2834414 SGTC_2162 5663267 200 µM -2.01053348393488 0.046196320084057 no 3193 0.0221873780039145 4690 6456493 SGTC_101 0490-5701 117.494 µM -2.01529336912795 0.0458106671716722 no 3194 0.0219369596476635 4591 4661669 SGTC_1508 1080-0625 72.9 µM -2.01743620838131 0.0456378978344383 no 3195 0.0218250059294969 4660 767111 SGTC_1227 3909-8010 46.6 µM -2.0194785504596 0.0454737191399929 no 3196 0.0217187522528749 4697 15982272 SGTC_2297 7971671 152.32 µM -2.02580326341683 0.0449683025637977 no 3197 0.0213924746929518 4657 909016 SGTC_2621 lithochol-11-enic acid 100 µM -2.02621275687158 0.0449357358550926 no 3198 0.0213714934639795 4637 6708711 SGTC_2039 Aminomethylbenzodioxan 200 µM -2.02762996416864 0.0448231729490457 no 3199 0.0212990142260131 4709 15053 SGTC_813 k007-0158 173 µM -2.03580922603511 0.0441779570873143 no 3200 0.0208847578208086 4685 6523916 SGTC_1753 st043925 64 µM -2.03704326889061 0.0440812636697723 no 3201 0.0208228530859645 4697 670181 SGTC_2081 5214970 32.255 µM -2.04083186330792 0.0437854740869968 no 3202 0.020633771135968 4664 2063512 SGTC_2871 9038510 12.99 µM -2.06261359054301 0.0421158246811004 no 3203 0.0195746777387622 4662 4945164 SGTC_502 l-744,832 89.3 µM -2.07405355079393 0.0412597686451827 no 3204 0.0190371688741187 4709 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3278 9139605 49.47 µM -2.07428465671879 0.0412426213626185 no 3205 0.0190264409626535 4671 7958859 SGTC_3287 9117173 37.0625 µM -2.07484926354539 0.0412007537313133 no 3206 0.0190002535966351 4728 2789709 SGTC_1946 st076057 65.1 µM -2.07583098188011 0.0411280378292037 no 3207 0.0189547929189247 4689 953009 SGTC_2066 5222451 176 µM -2.07873729380337 0.0409133771031547 no 3208 0.0188207515983524 4649 2281147 SGTC_2088 5278280 127.392 µM -2.0896615869614 0.0401146220882417 no 3209 0.0183241049724809 4724 791502 SGTC_2272 7805186 180 µM -2.0919922641802 0.0399458597654937 no 3210 0.0182196038545004 4702 2956062 YPR165W RHO1 SGTC_1119 parthenolide 318.541 nM -2.09855331414942 0.0394738764253973 no 3211 0.0179281477404182 4711 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3289 9119912 71.43 µM -2.10818591949393 0.0387891631045599 no 3212 0.0175074553740897 4700 17014829 SGTC_2342 7990637 118.86 µM -2.12248108749056 0.0377908831443838 no 3213 0.0168986796121377 4687 2033102 YER133W GLC7 SGTC_857 0438-0306 1.35 µM -2.1407051894486 0.0365487416097225 no 3214 0.0161489098840082 4727 4686136 SGTC_2013 4024628 200 µM -2.1427260985226 0.0364130794200287 no 3215 0.0160675492248766 4706 5230760 SGTC_3225 9130819 49.47 µM -2.14439396516096 0.0363014273688732 no 3216 0.0160006667010226 4690 4547121 SGTC_734 2023-0417 80 µM -2.14836986570608 0.0360363985326469 no 3217 0.0158421923538461 4706 3935732 SGTC_1325 1431-0015 227 µM -2.15059831099818 0.0358885473630686 no 3218 0.015753959380931 4712 1103340 SGTC_1313 1220-0047 237 µM -2.15995211018966 0.0352733601720923 no 3219 0.015388188543801 4729 3528706 SGTC_3037 9091026 49.47 µM -2.17604906972052 0.0342349499173624 no 3220 0.0147757957969617 4608 25236398 YIL048W NEO1 SGTC_700 3453-2283 142 µM -2.17753761676132 0.0341402068019608 no 3221 0.0147202391611709 4735 565664 SGTC_3203 9113543 49.47 µM -2.17980912972949 0.0339960449831134 no 3222 0.0146358064556345 4707 17018012 SGTC_1758 st042942 75.2445 µM -2.18483596880077 0.033678795477557 no 3223 0.0144504378651215 4697 669317 SGTC_1830 st055982 50.3 µM -2.19258459457912 0.0331945463222889 no 3224 0.0141686610312194 4711 455313 An antimicrobial agent. SGTC_259 usnic acid 108.925 µM -2.19396518969336 0.0331088711612979 no 3225 0.0141189560914168 4726 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2629 bisabolol 100 µM -2.20077721841961 0.0326888023340158 no 3226 0.0138758995678447 4708 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2437 5741531 144.16 µM -2.20792837200086 0.0322525595208 no 3227 0.0136246333440311 4721 2262990 SGTC_1445 4239-0156 97.7 µM -2.21280091568106 0.0319580801508394 no 3228 0.0134556870669513 4732 4008346 SGTC_2771 fluoxetine 41.05 µM -2.21912146641135 0.0315794001789781 no 3229 0.0132392310005934 4713 3386 A selective serotonin reuptake inhibitor. SGTC_297 0986-0032 24 µM -2.22182623923451 0.0314184874192248 no 3230 0.0131475253678561 4714 2847425 SGTC_1409 3909-8004 61.9 µM -2.2293193540961 0.0309762430813973 no 3231 0.0128963318981653 4760 2119279 SGTC_2636 apigenin dimethyl ether 100 µM -2.23549611771066 0.0306155747333255 no 3232 0.0126923981094249 4685 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1282 0886-0010 32.4 µM -2.236526097296 0.0305557726866259 no 3233 0.0126586648907868 4733 2836211 YNL267W PIK1 SGTC_2625 euphol 100 µM -2.25782791780203 0.0293404950051157 no 3234 0.0119781949836403 4704 6708538 A triterpene alcohol. SGTC_1695 st026914 34.495 µM -2.26321067130622 0.0290398414286919 no 3235 0.0118113528573095 4745 3289191 SGTC_2323 6148992 148.28 µM -2.2649450273714 0.0289435160298652 no 3236 0.0117580265804195 4702 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2588 indole-3-carbinol 100 µM -2.27125510259918 0.028595295120948 no 3237 0.0115657697248569 4709 3712 Induces cell cycle arrest. SGTC_699 0375-0592 111 µM -2.28644252736414 0.0277714450326833 no 3238 0.0111141913927652 4769 762578 SGTC_1679 SEC14.276 6.7 µM -2.29651104666047 0.0272362491926456 no 3239 0.0108233391378312 4685 1005053 YMR079W SEC14 SGTC_455 paf C-16 10 µM -2.29919166764176 0.0270952189763873 no 3240 0.0107470289788539 4715 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1954 st077032 68.9 µM -2.29925307144459 0.0270919956121559 no 3241 0.0107452864777734 4693 698907 SGTC_2520 obtusaquinone 4.71 µM -2.30059027577514 0.0270218790129433 no 3242 0.0107074006036919 4751 5967872 SGTC_104 0074-0074 590.992 µM -2.30314576239469 0.026888302783448 no 3243 0.0106353216288948 4705 3943124 SGTC_1144 3486-0183 12.5 µM -2.30597177595312 0.0267412283429257 no 3244 0.0105561047255571 4758 6744069 SGTC_1878 temozolomide 1 mM -2.36488355011846 0.0238250219722673 no 3245 0.00901787048167018 4736 5394 DNA alkylating agent. SGTC_2093 5331342 194.4 µM -2.38026777647228 0.0231090959412251 no 3246 0.00865003069641612 4745 33839 SGTC_387 norethindrone acetate 66.7 µM -2.38669224007226 0.0228155323845742 no 3247 0.00850035821318212 4749 541197 SGTC_2893 9048488 25.97 µM -2.39834498183564 0.0222910817124889 no 3248 0.00823467296823148 4746 6467338 SGTC_1757 st041620 31.8375 µM -2.40749900885725 0.0218862561141523 no 3249 0.00803110290219215 4735 5289815 SGTC_1196 1588-0294 184 µM -2.41493726565019 0.0215618966852826 no 3250 0.00786896002409053 4771 6144269 SGTC_472 calcifediol 10 µM -2.42126794400745 0.0212890444268436 no 3251 0.00773323619777776 4778 5283731 A vitamin D metabolite. SGTC_1861 st057647 17.4 µM -2.42489017820106 0.0211342435325166 no 3252 0.00765650914488058 4751 688668 SGTC_1560 lithocholic acid 53.1 µM -2.43991614236946 0.0205022192994275 no 3253 0.0073453358175035 4735 9903 A bile acid which acts as a detergent. SGTC_2557 derrustone 83.84 µM -2.45288126936848 0.0199698195669065 no 3254 0.00708585531644829 4746 629853 An antioxidant. SGTC_2127 5253358 187.912 µM -2.46573607447309 0.019453576664641 no 3255 0.0068366020257911 4722 20612 SGTC_191 3914-0123 66.505 µM -2.4751985522557 0.0190808512963872 no 3256 0.00665810611680175 4787 3144412 SGTC_2075 5212009 200 µM -2.48222871529033 0.0188078815026445 no 3257 0.00652817212105372 4741 780898 SGTC_1452 4194-0072 190 µM -2.49177123781457 0.0184426823782761 no 3258 0.00635539372196165 4775 1343545 SGTC_1388 3346-4487 254 µM -2.49644282988155 0.0182661104417249 no 3259 0.00627229440585266 4765 3345614 SGTC_1704 st028805 70.8 µM -2.5027502879839 0.0180299946260081 no 3260 0.00616162286474398 4780 2876101 SGTC_1749 st037932 54.2 µM -2.50289445252508 0.0180246284758698 no 3261 0.00615911368260963 4738 594497 SGTC_2611 pyromycin 23.93 µM -2.50706347835063 0.0178700353352663 no 3262 0.00608694233275272 4715 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_674 0498-0004 451 µM -2.51872992243253 0.0174434251687335 no 3263 0.00588894794894175 4752 4231473 SGTC_2692 st077426 47.7 µM -2.52671569801288 0.0171564467447784 no 3264 0.00575673316950448 4754 25238571 SGTC_1295 1013-0063 9.78 µM -2.52798423157671 0.01711123385128 no 3265 0.00573597521041103 4777 6826038 SGTC_2159 5658611 73.75 µM -2.5287031200012 0.0170856565659766 no 3266 0.0057242410195544 4754 793844 SGTC_3 0833-0587 95.581 µM -2.53643226174705 0.016812719977462 no 3267 0.00559942029619381 4684 5382644 SGTC_270 tamoxifen 5.46 µM -2.53963064214118 0.0167008723276867 no 3268 0.00554847961741678 4756 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_354 2783-3500 4.88 µM -2.54239489302038 0.0166047196709561 no 3269 0.00550478542445582 4751 6740761 SGTC_3184 9108758 49.47 µM -2.57136453188754 0.0156252067680819 no 3270 0.00506493189441873 4793 902885 SGTC_192 3455-0609 60.9 µM -2.57214600732881 0.0155994855738274 no 3271 0.00505351284742031 4783 3769639 SGTC_3126 9127922 49.47 µM -2.61123072979853 0.0143585931002479 no 3272 0.00451085015664664 4724 45595682 SGTC_1829 berberine 14.4 µM -2.63538144579146 0.0136351121334871 no 3273 0.00420213893270479 4730 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1950 st077106 7.18 µM -2.63582144507296 0.0136222283438425 no 3274 0.00419669426286464 4733 13831864 SGTC_2827 7993847 71.43 µM -2.6566107228381 0.0130253462124917 no 3275 0.0039465263324636 4766 2985692 SGTC_1619 st003326 88.7 µM -2.65767574093461 0.0129953868619067 no 3276 0.00393407778749774 4751 2849032 SGTC_698 k064-0052 127 µM -2.67772072007934 0.0124425258551578 no 3277 0.00370624979503497 4798 5088751 SGTC_1130 3454-2858 15.9 µM -2.74453553298842 0.0107442259380414 no 3278 0.00302982969846111 4751 715628 YIL048W NEO1 SGTC_2744 captopril 92.04 µM -2.74976660343654 0.0106202151116863 no 3279 0.00298188632254171 4794 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_545 4218-0007 221 µM -2.75335183073184 0.0105359433711735 no 3280 0.00294942325446433 4788 2840508 SGTC_2082 5219693 150 µM -2.75563305513502 0.0104826263880401 no 3281 0.00292893368023132 4758 2834649 SGTC_1184 1269-1718 139 µM -2.75859512164525 0.0104137476583437 no 3282 0.00290252039053477 4792 5403821 SGTC_896 0964-0007 44.5 µM -2.7604195863202 0.0103715188811275 no 3283 0.0028863583735277 4762 6756758 SGTC_152 4469-0003 551.229 µM -2.76587610381934 0.0102461127971246 no 3284 0.00283850494649684 4776 697280 SGTC_1728 st035614 33.7865 µM -2.81719553661731 0.00912990920250677 no 3285 0.00242225109029872 4751 15945546 SGTC_3130 9127414 49.47 µM -2.84760524067105 0.00851999715541172 no 3286 0.00220247635482089 4788 1494646 SGTC_1058 3448-5425 97.3 µM -2.88052597650804 0.00790030338874246 no 3287 0.00198506117631199 4776 7279705 SGTC_2756 carbadox 75.1 µM -2.88822739103829 0.00776118730201519 no 3288 0.00193709843796045 4740 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_636 0kpi-0074 126 µM -2.90157045138614 0.00752525973412822 no 3289 0.0018564863963555 4792 616434 SGTC_1161 k007-0610 110 µM -2.9065010031607 0.00743969122371172 no 3290 0.00182747863502489 4747 5843850 SGTC_618 k072-0232 33.2 µM -2.90878386061664 0.00740036398444267 no 3291 0.00181418807464967 4792 5872756 YGL099W LSG1 SGTC_2285 7945142 200 µM -2.92062995216016 0.00719921685144494 no 3292 0.00174662237974013 4771 2970608 SGTC_1552 6-methylflavone 10.6 µM -2.94932622261736 0.00673181488351356 no 3293 0.00159233808811312 4792 689013 SGTC_656 4090-1979 187 µM -2.95824716001269 0.00659208008902307 no 3294 0.00154696970377629 4797 22330961 SGTC_2128 5255449 168.493 µM -2.96220236024387 0.00653095200574453 no 3295 0.00152723482201395 4763 736008 SGTC_2941 9056145 11.23 µM -2.97040162472746 0.00640582604126954 no 3296 0.00148705321758805 4781 2119517 SGTC_2602 kawain 100 µM -3.02533284254672 0.00562090452955682 no 3297 0.00124179823119392 4778 5369129 SGTC_539 4859-0462 2.54 µM -3.02835653805935 0.0055802915032825 no 3298 0.00122943897553609 4784 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1699 st031318 29.054 µM -3.03374747823627 0.00550852882036581 no 3299 0.00120768256782724 4803 5340658 SGTC_266 formosanin C 406 nM -3.04314401131698 0.0053854031057922 no 3300 0.00117060131381564 4743 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3318 9139014 38.6185 µM -3.09104456642246 0.004794995588937 no 3301 0.000997268476452874 4795 16643984 SGTC_3047 9092122 49.47 µM -3.10527059170646 0.00463113253524578 no 3302 0.000950525121169016 4774 17173831 SGTC_157 1348-1695 65.819 µM -3.10667949324073 0.00461517917798324 no 3303 0.000946007040261104 4767 5380510 SGTC_154 3389-1638 511.116 µM -3.11241177660727 0.00455077559082869 no 3304 0.000927827341262598 4787 5238686 SGTC_309 k408-0051 1.48 µM -3.11698378764302 0.00449998439435533 no 3305 0.000913558098757039 4758 3640463 SGTC_3211 9128781 49.47 µM -3.12123701924787 0.00445318970511866 no 3306 0.000900465101296472 4740 17194361 SGTC_3100 9120536 49.47 µM -3.17228586685695 0.00392452035743971 no 3307 0.00075622024856536 4775 16421196 SGTC_2079 5212404 121 µM -3.19048646641779 0.00375008751310114 no 3308 0.000710167465227581 4784 758462 SGTC_2698 st077697 67.5 µM -3.19139319880062 0.00374158215634321 no 3309 0.000707942234467285 4775 3154499 SGTC_3342 9147791 14.508 µM -3.22816410147013 0.00341090972678382 no 3310 0.000622937403006801 4795 1838168 SGTC_2243 6634756 200 µM -3.2406985106039 0.00330434230249819 no 3311 0.000596186095814549 4789 885676 SGTC_1678 st019265 80.2 µM -3.24273257041249 0.00328733393206237 no 3312 0.000591946396866813 4783 5367020 SGTC_58 0957-0393 9 µM -3.27759783822366 0.00300778389512577 no 3313 0.000523472204768622 4513 6997992 SGTC_3251 9135047 49.47 µM -3.31555729168514 0.00272793642804947 no 3314 0.000457302957681513 4805 17682963 SGTC_1320 1313-0481 95.3 µM -3.35658995763628 0.00245205670809166 no 3315 0.0003945502292763 4779 6813365 YLR208W SEC13 SGTC_1815 st051655 58.2 µM -3.35989008525398 0.00243100455078464 no 3316 0.000389867437204336 4802 5984156 SGTC_1889 st059080 5.18 µM -3.3981517783711 0.00219859048608023 no 3317 0.000339213849087178 4795 176925 Isolated from Daphnopsis sellowiana. SGTC_1808 st050063 61.5 µM -3.41409424315387 0.00210784179660286 no 3318 0.000319972177497562 4802 4011993 SGTC_2182 6325192 200 µM -3.42239108029007 0.0020619706598735 no 3319 0.000310364809366063 4803 736248 SGTC_1814 st052110 31.539 µM -3.44015273536239 0.00196680214294366 no 3320 0.000290692995782303 4795 674163 SGTC_1934 st074720 32.6 µM -3.45025597303927 0.0019144652834125 no 3321 0.000280027622118233 4781 17250992 SGTC_1061 3448-9325 110 µM -3.47098428347697 0.00181102951406583 no 3322 0.00025927717457744 4800 723482 SGTC_554 4483-2211 187 µM -3.53570446467752 0.00151993268222173 no 3323 0.000203344694246094 4805 747107 SGTC_138 0850-0259 40.9225 µM -3.56636146905644 0.00139752903960044 no 3324 0.000180986007208362 4777 6813004 SGTC_514 4466-0038 2.65 nM -3.64768385423443 0.00111516616444908 no 3325 0.00013230747634802 4746 5722064 SGTC_453 enantio-paf c16 10 µM -3.6598452561471 0.00107775221608035 no 3326 0.000126183802017921 4525 13871343 A lipid and platelet activating factor SGTC_2068 5226020 147 µM -3.71176450389256 0.000930619324311168 yes 3327 0.000102909718350884 4802 1810509 SGTC_1230 0170-0365 3.77 µM -3.72676789068575 0.000891676688038376 yes 3328 9.69754571219034e-05 4802 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_513 4245-1575 41.7 µM -3.79331872689481 0.00073634924596217 yes 3329 7.4323578612371e-05 4760 719745 SGTC_2078 5212016 200 µM -3.81760514679591 0.00068617335522908 yes 3330 6.73766814707266e-05 4803 1899708 SGTC_2351 9026858 72.31 µM -3.89493941550016 0.000546651014100798 yes 3331 4.91116386175578e-05 4791 1409300 SGTC_97 0535-0701 19.132 µM -3.90411581135346 0.000531963526593971 yes 3332 4.72852450317823e-05 4800 2832013 YGL099W LSG1 SGTC_524 r073-0010 27.8 µM -3.91640048669558 0.000512872205028507 yes 3333 4.49404457997136e-05 4805 2772106 SGTC_198 3454-2873 16.191 µM -3.96212890099958 0.000447243182553468 yes 3334 3.71422070720358e-05 4808 710957 SGTC_2751 anetholtrithion 17.25 µM -3.99128098740538 0.000409562798741451 yes 3335 3.28586805722048e-05 4793 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1745 st081495 74 µM -3.99688085721292 0.000402670817981669 yes 3336 3.20912916795174e-05 4783 13842402 YBL026W LSM2 SGTC_3328 9140624 29.0385 µM -4.02076076728144 0.000374471702553132 yes 3337 2.90052472078005e-05 4805 4904392 SGTC_1604 st002052 72.4 µM -4.06398570843208 0.000328040175670522 yes 3338 2.41208904708736e-05 4808 6254834 YHR062C RPP1 SGTC_897 1000-0139 31.4 µM -4.28032515306453 0.000165989833185865 yes 3339 9.33102280047328e-06 4794 6151020 SGTC_1714 st033236 13.627 µM -4.36600218002055 0.000125653941269383 yes 3340 6.32706083896265e-06 4805 2916566 SGTC_2759 disulfiram 3.38 µM -4.36832255212124 0.000124701614851336 yes 3341 6.26022428978701e-06 4797 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3219 9131112 49.47 µM -4.37150924953158 0.000123404760251383 yes 3342 6.1695310992521e-06 4787 17612988 YMR079W SEC14 SGTC_2594 a-mangostin 100 µM -4.40088883032573 0.00011203026821106 yes 3343 5.39041758035185e-06 4803 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2544 sphondin 68.51 µM -4.43852207167941 9.88951117054664e-05 yes 3344 4.52893485569186e-06 4808 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3125 9127534 49.47 µM -4.6554144823064 4.73160032388392e-05 yes 3345 1.61664795690339e-06 4807 1639235 SGTC_2752 diclazuril 33.15 µM -4.68252812090266 4.3054756965572e-05 yes 3346 1.41679150060279e-06 4804 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_304 1310-0298 97 µM -4.78678027905661 2.98145910139945e-05 yes 3347 8.47391001832192e-07 4775 1550234 SGTC_1937 st074714 47.2 µM -4.94135869496778 1.70589354647838e-05 yes 3348 3.8790016021628e-07 4807 17250970 SGTC_103 0844-0104 51.839 µM -5.16551076560593 7.37751944238832e-06 yes 3349 1.19891612948049e-07 4797 5375804 SGTC_3266 9136860 49.47 µM -6.43200034642882 3.40992977564552e-08 yes 3350 6.29677268702773e-11 4795 4871271 YPR165W RHO1 SGTC_2584 androsterone 48.74 µM -6.68923267599781 1.00078607175173e-08 yes 3351 1.12171896207808e-11 4808 2754130 A steroid. SGTC_2582 agaric acid 100 µM -7.58535328181659 9.80361847883206e-11 yes 3352 1.65791171049909e-14 4798 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1718 roemerine 11.9335 µM -8.48454995393858 5.41635679837371e-13 yes 3353 1.08277612105982e-17 4807 235224 An aporphine alkaloid with mutagenic activity.