SGTCid condition conc unit CAM1|YPL048W.score CAM1|YPL048W.strain.pval CAM1|YPL048W.strain.significant CAM1|YPL048W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1032 k061-1018 98.7 µM 5.12080950208286 1.66748205309305e-07 yes 1 1.52113427727248e-07 7 4005393
SGTC_3194 9111903 49.47 µM 4.95654584232882 3.92118329003964e-07 yes 2 3.58787212799634e-07 8 17087251
SGTC_2024 5144227 134 µM 4.5712246812897 2.63113181149087e-06 yes 3 2.42441022996569e-06 24 3475211
SGTC_1860 st056228 74.6 µM 4.3792574516882 6.43969035906705e-06 yes 4 5.95421901837921e-06 8 688679
SGTC_2517 totarol 10 µM 3.88600966917009 5.46294623675641e-05 yes 5 5.09527246218771e-05 22 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1851 st056236 18.9 µM 3.87990370233726 5.60132251047292e-05 yes 6 5.22489140679878e-05 17 5393171
SGTC_2829 7992743 58.44 µM 3.87868971006194 5.62922572710983e-05 yes 7 5.25103046443029e-05 41 16462845
SGTC_1681 tripelennamine 100 µM 3.8721539265803 5.7817155136029e-05 yes 8 5.39388929990199e-05 23 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2335 9018011 154.17 µM 3.72347021926985 0.000105044674649884 yes 9 9.82515247469609e-05 32 6458208
SGTC_1010 4112-3296 15.2 µM 3.70286400267551 0.000113918700006584 yes 10 0.000106589586477798 22 704384
SGTC_770 0389-1121 67.2 µM 3.69905464111642 0.000115634390285503 yes 11 0.000108202006350345 34 6753108
SGTC_3300 9124615 50.48 µM 3.63498065654876 0.000148384884024011 yes 12 0.000139000746882387 25 24824903
SGTC_2882 9058044 58.44 µM 3.60379136642235 0.000167300863319742 yes 13 0.000156804411807831 23 18076804
SGTC_1453 4237-0541 195 µM 3.56481615514694 0.000194112709715197 yes 14 0.000182055659024615 36 739892
SGTC_1042 0350-0096 82 µM 3.56348528904619 0.000195095535171335 yes 15 0.000182981606617057 37 3122515
SGTC_1136 pergolide 1.05886 µM 3.489976722823 0.000257198229040268 yes 16 0.000241531310524187 60 47811 A dopamine receptor agonist.
SGTC_754 3474-0146 171 µM 3.44457468334901 0.000304294054687157 yes 17 0.000285979301488445 41 24762078
SGTC_2241 6772625 37.8075 µM 3.39995222245514 0.000358298060913557 yes 18 0.000336988142865444 45 2285411
SGTC_2647 atorvastatin 60.16 µM 3.38553761804183 0.000377563852981885 yes 19 0.000355194859668256 32 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1637 st007924 17.4 µM 3.34836681660993 0.000431771695723212 yes 20 0.00040644670480553 49 683336
SGTC_1994 st072947 40.9 µM 3.34685647989965 0.000434119860556627 yes 21 0.000408667573570742 35 5286565 YDL195W SEC31
SGTC_3179 9107801 49.47 µM 3.34405823677855 0.00043850169101753 yes 22 0.000412812020572151 24 4818259
SGTC_772 k072-0172 35.3 µM 3.30587754539334 0.000502533262057716 yes 23 0.00047339727763415 41 5861980
SGTC_2350 9023895 38.85 µM 3.29217923827723 0.00052754238814798 yes 24 0.000497071152421076 53 2997209
SGTC_1742 st038235 28.8875 µM 3.25755272102996 0.000595984092445316 yes 25 0.000561886906285466 153 564103 YBR002C RER2
SGTC_2847 9005661 71.43 µM 3.25074626578568 0.000610366890979995 yes 26 0.000575512668158795 18 2991449
SGTC_3044 9093193 49.47 µM 3.21274421946482 0.000696733583201598 yes 27 0.000657366594783441 62 25236277
SGTC_552 k242-0005 476 µM 3.18705180692831 0.000761364762132238 yes 28 0.000718655137075561 45 4088318
SGTC_183 3914-0051 30.55 µM 3.14522857647456 0.000878485417672027 yes 29 0.000829785550177819 56 1596232
SGTC_2146 5545642 200 µM 3.14386542703394 0.000882567686894578 yes 30 0.000833660479016667 44 825326
SGTC_2174 5790901 200 µM 3.13066175707319 0.000923021475613707 yes 31 0.000872064584646408 68 786020
SGTC_859 0439-0102 54.6 µM 3.1075771804622 0.00099786467424978 yes 32 0.000943138623551376 46 610143
SGTC_1027 k015-0025 8.67 µM 3.10389413986211 0.0010103082187873 no 33 0.00095495827233621 60 3598955
SGTC_2021 4019055 173 µM 3.04607544545093 0.00122526147234627 no 34 0.00115924825420901 209 44827708 YER133W GLC7
SGTC_2528 xanthyletin 44.79 µM 3.02506432242769 0.0013132208227561 no 35 0.00124290127571368 54 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2556 citropten 84.59 µM 3.0185031441152 0.00134184835408346 no 36 0.00127013382908963 82 2775 A potential DNA crosslinker.
SGTC_2244 6635614 200 µM 2.98953343181345 0.00147519130570734 no 37 0.00139701934785283 22 836499
SGTC_2840 9008771 71.43 µM 2.97796225377349 0.00153175049612103 no 38 0.00145085858913148 36 2992978
SGTC_340 k038-0059 454 µM 2.93637077777196 0.0017517584201522 no 39 0.00166038571265202 82 23733424
SGTC_52 0329-0193 875 nM 2.92484444466159 0.00181762378233589 no 40 0.00172314223537235 77 3739292
SGTC_95 0471-0001 561.058 µM 2.92384714347593 0.00182342725290564 no 41 0.00172867238810674 71 4015405
SGTC_2787 5284540 71.43 µM 2.91689983423778 0.00186432464629123 no 42 0.00176764642303905 77 736958
SGTC_3175 9106517 49.47 µM 2.88812194508701 0.00204276406965373 no 43 0.00193774796132207 55 41468073
SGTC_2522 biochanin a 4.94 µM 2.88566640399087 0.00205868555845154 no 44 0.00195292960042011 49 5280373 A possible chelator.
SGTC_384 k007-0144 5.16 µM 2.88450293219243 0.00206626864313355 no 45 0.00196016053905484 123 6824886
SGTC_226 1,3-diallylurea 8.28947 mM 2.8825824498672 0.00207884110876991 no 46 0.00197214948447173 55 74537 YKL182W FAS1
SGTC_182 3448-4371 550.524 µM 2.85958631285107 0.00223487031611218 no 47 0.00212096982596914 68 3491403
SGTC_2968 9090663 33.37 µM 2.84465377315851 0.00234179273651606 no 48 0.00222298599947545 92 25236811
SGTC_2171 5739187 198.077 µM 2.819321397537 0.00253381830997292 no 49 0.00240626523130631 68 2262761
SGTC_1137 ixabepilone 100 µM 2.78599566296263 0.00280808990300492 no 50 0.00266817928439584 113 154225 A novel microtubule stabilizer.
SGTC_1165 k072-0275 30.3 µM 2.76175698188901 0.00302410249055634 no 51 0.00287456264943897 101 6153523 YGL055W OLE1
SGTC_1651 st011928 86.1 µM 2.75611502249201 0.00307648304441988 no 52 0.0029246211833491 62 720198
SGTC_3151 9099821 49.47 µM 2.73917717514949 0.00323867983028585 no 53 0.00307965854005289 87 17174189
SGTC_1804 st050076 49.1 µM 2.6847777696703 0.00381292348460873 no 54 0.00362890232324065 94 3895976
SGTC_103 0844-0104 51.839 µM 2.67758411633885 0.00389532877242542 no 55 0.00370776149461072 248 5375804
SGTC_2564 betulinic acid 100 µM 2.66209905718246 0.00407815101675698 no 56 0.00388275109658368 122 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2449 5812982 45.77 µM 2.64944046356927 0.00423326808420136 no 57 0.00403125882070762 61 776185
SGTC_958 1222-0007 33 µM 2.64717083621688 0.00426163110263993 no 58 0.00405841683761762 116 7312461
SGTC_1293 1000-1278 195 µM 2.59230732256521 0.00500099466019584 no 59 0.00476672832433734 97 678847
SGTC_402 epigallocatechin gallate 10 µM 2.58245103751562 0.00514531541191308 no 60 0.00490506406209874 126 65064 An antioxidant.
SGTC_893 0958-0369 48.9 µM 2.58143282673058 0.00516043381126885 no 61 0.00491955686065574 110 6819948
SGTC_1534 6-azauridine 81.6 µM 2.57463849954029 0.00526233201988685 no 62 0.0050172451504594 120 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1910 st062352 60.4 µM 2.54332795251624 0.00575540614865522 no 63 0.00549010582813051 142 2245730
SGTC_593 1203-0218 61.7 µM 2.54232292055358 0.00577189093490678 no 64 0.00550591919710875 88 3666956
SGTC_610 4215-0184 155 µM 2.51899660519532 0.00616645100777063 no 65 0.00588448957010971 100 5605015
SGTC_1317 1273-0028 910 nM 2.51391395005831 0.00625552861459444 no 66 0.0059699781410107 137 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2927 9011802 47.9 µM 2.48521198084361 0.00678025928824883 no 67 0.00647371553475117 128 43912568
SGTC_1407 3909-7909 12.3 µM 2.48226481260902 0.00683628128359021 no 68 0.00652751078584462 99 4411780
SGTC_2412 st077135 33.4 µM 2.46270271301665 0.00721860495973166 no 69 0.00689470991703398 142 13258915
SGTC_532 1548-0774 215 µM 2.46126847155682 0.00724736393585217 no 70 0.00692233617680317 119 5932993
SGTC_609 0986-0026 86.3 µM 2.45740384239076 0.00732535979953122 no 71 0.00699726348740858 150 2848610
SGTC_1052 3253-3998 198 µM 2.44711441366975 0.00753663958179464 no 72 0.00720025587465554 142 5450317
SGTC_3204 9114183 49.47 µM 2.44031973312212 0.00767908475992617 no 73 0.0073371338414987 130 17027248
SGTC_1043 0916-0009 19.3 µM 2.40884298557228 0.00837033623645798 no 74 0.00800159062809538 144 3101130
SGTC_780 0109-0199 192 µM 2.40779999393085 0.00839414754637622 no 75 0.00802448529337877 145 610414
SGTC_2773 thioridazine 9.09 µM 2.39041052372716 0.00879999822562678 no 76 0.00841477468960769 109 5452 An antipsychotic.
SGTC_565 1418-0001 44.5 µM 2.3885618253207 0.00884414011331163 no 77 0.00845723106785822 144 2862145
SGTC_2994 9053520 71.4286 µM 2.3765438037707 0.00913585744978505 no 78 0.00873784315732611 119 4647384
SGTC_1405 3909-7894 12 µM 2.34733770608592 0.00988014659195386 no 79 0.00945405422899746 119 7104060
SGTC_480 am 92016 50 µM 2.33399256267603 0.0102375040826579 no 80 0.00979805567923202 111 2129 K+ channel blocker.
SGTC_154 3389-1638 511.116 µM 2.33268032690636 0.0102732446099779 no 81 0.00983246474120843 140 5238686
SGTC_718 1130-0073 349 µM 2.3227532561875 0.0105471645685936 no 82 0.0100962057510132 140 6740020
SGTC_1446 4239-0190 62 µM 2.30292012886645 0.0111135339382146 no 83 0.0106416686985088 183 1340085
SGTC_3289 9119912 71.43 µM 2.2941617582121 0.0113719477162599 no 84 0.0108906045131483 159 17014829
SGTC_2063 5246145 200 µM 2.2939557037545 0.0113780896491811 no 85 0.0108965216295439 172 711240
SGTC_1250 0485-0349 40.2 µM 2.28527991704504 0.011639320619701 no 86 0.0111482098750072 180 6842794 YDL195W SEC31
SGTC_1390 3413-2614 145 µM 2.27232595926558 0.0120390564097326 no 87 0.0115334150089708 181 3421432
SGTC_1134 3477-0009 42.5 µM 2.26506738668181 0.0122682051883552 no 88 0.0117542722994004 196 3973534
SGTC_1835 st008666 49.2 µM 2.26366619877031 0.0123128723946228 no 89 0.0117973264647585 129 690455
SGTC_1522 st012842 45.6 µM 2.26353252004891 0.0123171411709416 no 90 0.0118014411393792 165 3491067 YOR116C RPO31
SGTC_1324 1418-0026 34.4 µM 2.24533636020066 0.0129102960352676 no 91 0.0123732737543221 157 1372513
SGTC_767 0929-0023 86 µM 2.236125223475 0.0132198653516108 no 92 0.0126717848146564 278 1204563
SGTC_1820 st053765 18.6 µM 2.23267678326992 0.0133374000517326 no 93 0.012785133277583 155 3690829
SGTC_1284 0929-0043 16 µM 2.23228900614963 0.0133506731096382 no 94 0.0127979340088112 163 1239883
SGTC_3307 9126885 69.2785 µM 2.22739929695214 0.0135190221998087 no 95 0.0129602996872541 187 24824909
SGTC_2176 5809774 33.9695 µM 2.21650880702561 0.0139005712586252 no 96 0.0133283376975869 140 2870539
SGTC_1429 4049-0205 9.46 µM 2.21604441702269 0.0139170455582068 no 97 0.0133442301644404 161 22774478
SGTC_2770 toltrazuril 17.5 µM 2.21457911745077 0.0139691376689872 no 98 0.0133944833374718 177 68591 Kills coccidiodes.
SGTC_662 k832-1615 104 µM 2.21224916676017 0.0140523146774204 no 99 0.0134747266680134 169 5878478
SGTC_856 0433-0016 11.3 µM 2.19203346189605 0.0147920866274523 no 100 0.0141885452752648 169 3911780
SGTC_3050 9093513 49.47 µM 2.18201288042044 0.0151710326901567 no 101 0.0145542910630784 156 25236664
SGTC_380 3970-0968 6 µM 2.173549531896 0.0154975570992676 no 102 0.0148694910532996 160 2891601
SGTC_1392 3455-1037 33.9 µM 2.16532072511756 0.0158207982132181 no 103 0.0151815661440777 161 981132
SGTC_2504 purpurogallin 52.29 µM 2.16499784394114 0.0158335985349938 no 104 0.0151939251929846 176 5281571 An antioxidant.
SGTC_2899 9053889 58.44 µM 2.16409463885583 0.0158694524350316 no 105 0.0152285434436761 124 6470052
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.16178235101744 0.0159615591063386 no 106 0.0153174782456706 174 75037 A free radical scavenger.
SGTC_2337 9009472 200 µM 2.15610267054319 0.0161897484470005 no 107 0.0155378245150702 229 5742383
SGTC_704 1310-0270 142 µM 2.15052207075722 0.0164166735249579 no 108 0.0157569710556837 208 5718033
SGTC_1827 berberine 7.24 µM 2.1463428750354 0.0165883914387416 no 109 0.0159228166413759 168 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3061 glucosamine 200 µM 2.14524938923322 0.0166335743048182 no 110 0.0159664563280971 132 91431 and experimental redox chemotherapeutic
SGTC_3249 9135183 49.47 µM 2.14379956620655 0.0166936433818049 no 111 0.0160244750611243 179 4902779
SGTC_1494 4358-1428 177 µM 2.13384838880591 0.0171109703318165 no 112 0.0164275967069655 182 1564571
SGTC_1026 k007-1105 30.6 µM 2.13225828032034 0.017178474845356 no 113 0.0164928098546068 289 7066794
SGTC_490 phenamil 164 µM 2.12636742111365 0.0174305447690834 no 114 0.0167363391171542 100 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1421 4029-0249 71.4 µM 2.1182495508874 0.0177830788568107 no 115 0.0170769693559036 206 2894095
SGTC_3128 9127691 49.47 µM 2.11734823348003 0.0178225928950997 no 116 0.0171151520733319 158 41316314
SGTC_2061 5245884 80.95 µM 2.11401082527948 0.017969558674944 no 117 0.0172571713701417 193 573863
SGTC_2348 9022543 33.42 µM 2.11301595018688 0.0180135683407478 no 118 0.0172997013563044 194 3162678 YDL140C RPO21
SGTC_2248 tofa 1.1 µM 2.11151469941312 0.0180801521795869 no 119 0.0173640479037273 187 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1314 1222-0010 41.1 µM 2.11004309624013 0.0181456245961661 no 120 0.0174273219782598 171 3526027
SGTC_1850 st056238 17 µM 2.10758765868743 0.0182553182140107 no 121 0.0175333360076615 196 5393177
SGTC_2721 ifenprodil 61.44 µM 2.09804631023409 0.0186869453526943 no 122 0.0179505273258446 193 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2933 9026794 32.47 µM 2.09794059952501 0.0186917756818913 no 123 0.0179551964868698 216 17586027
SGTC_1933 st074711 15.9 µM 2.09668155491744 0.0187493880263345 no 124 0.0180108871930642 228 17250958
SGTC_2801 7907800 81.82 µM 2.09352782451011 0.0188943625847243 no 125 0.0181510314541573 216 6620925
SGTC_2378 9074213 121.43 µM 2.08731486516489 0.0191827586651808 no 126 0.0184298409655638 211 657714
SGTC_968 1309-0633 340 µM 2.08497465441082 0.0192923536650576 no 127 0.0185358006326413 181 3761976
SGTC_69 0096-0274 206.684 µM 2.08295306626738 0.0193874551048447 no 128 0.0186277509168136 274 6741392
SGTC_2681 menadione 3.18 µM 2.07767566517131 0.0196375984787663 no 129 0.0188696209278119 191 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_85 0868-0259 160.055 µM 2.06239425879999 0.0203774290924753 no 130 0.0195851077322606 158 83173
SGTC_94 0334-0113 514.748 µM 2.05548682557373 0.020719518777367 no 131 0.0199160034316815 203 6795178
SGTC_2474 5321570 43.32 µM 2.05146880962596 0.0209207386874435 no 132 0.0201106570322285 175 2841384
SGTC_1985 st071382 65.5 µM 2.04842734704873 0.0210741510827421 no 133 0.020259072110143 189 6123237
SGTC_762 1165-0429 115 µM 2.04561118098503 0.0212170470973515 no 134 0.0203973202623082 209 5967793
SGTC_2489 cantharidin 73.42 µM 2.04522466467822 0.0212367232622243 no 135 0.0204163569548873 259 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_886 0866-0150 153 µM 2.03846218759583 0.0215834817347046 no 136 0.0207518662801728 236 271463
SGTC_335 4077-0256 27.6 µM 2.03495821168501 0.0217650286204305 no 137 0.0209275389505383 218 3121989
SGTC_404 fumagillin 50 µM 2.03153432752855 0.0219436701721539 no 138 0.0211004104784003 219 12015870 A methionine aminopeptidase binder.
SGTC_851 0394-0702 453 µM 2.02474644635927 0.0223014903287909 no 139 0.0214467033440085 196 762646
SGTC_1464 k208-0027 110 µM 2.02372989848521 0.0223554986790018 no 140 0.0214989752595835 200 X1464
SGTC_3144 9087057 49.47 µM 2.01153765769955 0.0230119044912461 no 141 0.0221343484213826 206 17249618
SGTC_1303 1160-0052 261 µM 2.00777622207946 0.0232176603390904 no 142 0.0223335383386042 209 3562476
SGTC_1620 st003704 16.5 µM 2.00722860393452 0.0232477445874444 no 143 0.0223626636255425 177 2834414
SGTC_521 r062-0005 13.8 µM 2.00577406436141 0.0233278113294129 no 144 0.0224401794898781 206 2832033
SGTC_2262 9014885 67.46 µM 2.00424371272882 0.0234123016381957 no 145 0.022521980063259 120 6457424
SGTC_2463 5473429 200 µM 2.00039729206736 0.0236257990684775 no 146 0.0227286902857691 197 5399405
SGTC_657 3534-0529 86.7 µM 1.98954191732297 0.0242371808190996 no 147 0.0233207099438244 212 1049549
SGTC_3020 9089140 49.47 µM 1.98929941198563 0.0242509891999415 no 148 0.0233340822772565 215 17217859
SGTC_403 arphamenine a 50 µM 1.98533047224515 0.0244779232270421 no 149 0.0235538579448161 232 5487158 An arginine aminopeptidase inhibitor.
SGTC_1328 1441-0025 69.2 µM 1.97623311159959 0.0250048195594609 no 150 0.0240641906652637 181 4562601
SGTC_1618 st003135 44.5 µM 1.9716079772121 0.0252763212100767 no 151 0.0243271879207908 192 1270615
SGTC_675 1309-0189 238 µM 1.97001823517917 0.0253702097750138 no 152 0.0244181403541332 209 4246530
SGTC_339 3091-4833 71.4 µM 1.96840906177399 0.0254655432771951 no 153 0.024510495044448 181 3240077
SGTC_3019 9081971 49.47 µM 1.95981984398485 0.0259794894296741 no 154 0.0250084254948697 214 16451803
SGTC_833 3852-0053 558 µM 1.95930577796157 0.0260105224273173 no 155 0.0250384937509556 244 3123681
SGTC_1361 1608-0041 5.61 µM 1.94831328997147 0.0266815702368581 no 156 0.0256887439513444 226 X1361
SGTC_1356 1502-0781 85.8 µM 1.93647519122636 0.0274203485256266 no 157 0.026404764081782 233 567702
SGTC_890 0929-0006 47.2 µM 1.92771927471494 0.0279776857580896 no 158 0.0269450266516326 205 1378169
SGTC_519 k048-0011 62.8 µM 1.91544003251342 0.0287751576188746 no 159 0.0277182049574087 253 6836379
SGTC_2257 7960413 200 µM 1.91215032327016 0.0289919882486096 no 160 0.0279284578675122 284 2974689 YIL048W NEO1
SGTC_3202 9113761 49.47 µM 1.91021571696375 0.0291201344650303 no 161 0.0280527221661345 322 4798415
SGTC_1076 itraconazole 331 nM 1.90918295429239 0.0291887359774086 no 162 0.0281192472118404 246 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1518 st038567 90.8 µM 1.90308669212821 0.0295964219900405 no 163 0.0285146170653542 210 77966
SGTC_971 1315-0384 26.7 µM 1.90230185980413 0.0296492491985149 no 164 0.0285658513471966 261 6769120
SGTC_332 4112-0506 40.9 µM 1.90061727591518 0.0297629031120596 no 165 0.0286760804986599 226 2790355
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.8995711199168 0.0298336659421121 no 166 0.0287447126001409 260 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_563 tetrahydrosecaminediol 614 µM 1.89912345262272 0.0298639891267417 no 167 0.0287741230997751 267 334274 A psychoactive constituent of the cannabis plant.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.89852861239655 0.0299043207647272 no 168 0.0288132411575628 322 688664
SGTC_2643 anethole 100 µM 1.89810693586176 0.0299329388319783 no 169 0.0288409983450497 273 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_921 1561-0023 372 µM 1.88128994950765 0.03109291326841 no 170 0.0299662437253848 250 24050882
SGTC_1868 st057644 42.7 µM 1.87979743922339 0.0311976339750755 no 171 0.0300678448033399 280 688665
SGTC_788 1182-0090 188 µM 1.87580518494328 0.0314791816815814 no 172 0.0303410178850864 376 5715185
SGTC_2628 lathosterol 100 µM 1.87153790855974 0.0317824440609049 no 173 0.0306352802869363 268 6710616
SGTC_3205 9113483 49.47 µM 1.86945753454289 0.0319311628023218 no 174 0.0307795932111353 301 17018033
SGTC_1376 2910-0861 41.3 µM 1.86700186749446 0.0321074490722046 no 175 0.0309506635308035 283 1112859
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.86598198612459 0.0321808996126598 no 176 0.0310219429128322 332 91467 include heat shock
SGTC_2893 9048488 25.97 µM 1.85273090697418 0.0331478958664281 no 177 0.0319604688757729 242 6467338
SGTC_1841 st054148 70 µM 1.85022738381393 0.0333332522396507 no 178 0.0321403918558439 245 675442
SGTC_806 3966-4455 5.86 µM 1.84645042001658 0.033614506378198 no 179 0.0324134160166888 233 714982
SGTC_2948 9070189 9.45 µM 1.83211029899996 0.0347001922627677 no 180 0.0334674946353409 263 6473636 YDL196W YDL196W
SGTC_1759 st043059 70 µM 1.83108518327216 0.0347788938191516 no 181 0.0335439148474519 280 669426
SGTC_1514 1189-1591 158 µM 1.82500568829029 0.0352486541288448 no 182 0.0340000854759296 335 767698 YMR146C TIF34
SGTC_317 4495-0002 170 µM 1.81649019652912 0.0359153818085669 no 183 0.0346476052100669 246 15991618
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.8155774223618 0.0359874572741014 no 184 0.0347176097884728 303 6708784 An antioxidant flavonoid
SGTC_2680 butyl paraben 22.24 µM 1.80902055691357 0.0365086967744592 no 185 0.0352239048803386 224 7184 An antifungal and steroid mimetic.
SGTC_863 0466-0191 129 µM 1.8082040667402 0.0365740342013902 no 186 0.0352873729639912 339 765160 YPR165W RHO1
SGTC_899 1083-0020 478 µM 1.80299302435073 0.0369932907962963 no 187 0.0356946551022785 313 767123
SGTC_50 0929-0078 56.389 µM 1.79999376308759 0.0372363736062132 no 188 0.0359308115209116 298 1377751
SGTC_1817 st052116 64.4 µM 1.795307945547 0.0376187585712644 no 189 0.0363023249056937 269 4361398
SGTC_629 3448-6466 76.7 µM 1.78664516203796 0.0383341226119529 no 190 0.0369974287374987 309 573744
SGTC_2032 5185112 25.99 µM 1.78319063281055 0.0386224701402986 no 191 0.037277638387227 252 5718189
SGTC_185 k048-0037 25.491 µM 1.77668059935846 0.0391706613349524 no 192 0.0378104030378069 268 6827589
SGTC_3131 9127911 49.47 µM 1.77375280879091 0.0394192583925067 no 193 0.0380520235604172 292 45595681
SGTC_358 0075-0058 9.45 µM 1.76726828045248 0.0399744267198069 no 194 0.0385916546698971 406 1069125
SGTC_1045 1348-1485 165 µM 1.75984798629742 0.0406174880597959 no 195 0.0392167921801032 358 6810614
SGTC_1506 4226-2149 212 µM 1.75977675757967 0.0406237013668664 no 196 0.0392228326859105 354 991114
SGTC_2461 5755302 26.15 µM 1.75814197203473 0.0407665164632548 no 197 0.0393616778779298 328 2788904
SGTC_484 loperamide 105 µM 1.75809991660072 0.0407701958000315 no 198 0.0393652549887638 165 3955 An opioid-receptor agonist.
SGTC_789 1309-1135 70.6 µM 1.74849275198858 0.0416177929548572 no 199 0.0401893697865566 331 3092424
SGTC_3081 9117243 49.47 µM 1.74293427310295 0.0421146757663929 no 200 0.0406725482315878 281 45595589
SGTC_2825 7998094 58.44 µM 1.7409438855489 0.0422937634077669 no 201 0.0408467075623225 309 2987815
SGTC_683 panaxydol 45 µM 1.73671460486092 0.042676343869349 no 202 0.0412187792744988 317 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_810 3825-7150 143 µM 1.72934143499964 0.0433500073194403 no 203 0.0418740024750749 304 22330411 YGL099W LSG1
SGTC_416 estradiol valerate 100 µM 1.72922882989958 0.0433603618777407 no 204 0.041884074229772 305 13791 A steroid.
SGTC_2118 5526350 200 µM 1.72545684103141 0.0437083689847105 no 205 0.0422225876371429 329 743594
SGTC_294 k038-0071 157 µM 1.72019777880892 0.0441973325698833 no 206 0.0426982483300952 362 24152826
SGTC_964 1287-0107 19.4 µM 1.70508887516896 0.0456266572498445 no 207 0.0440889250620276 357 51516812 YPR165W RHO1
SGTC_206 4546-0025 72.014 µM 1.7003071225542 0.046086682061645 no 208 0.0445365857052645 403 6620745 YIL048W NEO1
SGTC_3316 9136639 10.545 µM 1.69264082317306 0.0468319797626487 no 209 0.045261927796638 298 4903665
SGTC_2766 oltipraz 83.91 µM 1.69061084095757 0.0470309398367922 no 210 0.0454555763856647 316 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_824 1304-0008 100 µM 1.689391004876 0.047150822512843 no 211 0.045572261828503 372 768245
SGTC_1327 1436-0082 2.18 µM 1.6882958769606 0.0472586577270489 no 212 0.0456772231513571 313 15992205
SGTC_706 4262-0057 46.9 µM 1.68393950871338 0.0476895797010331 no 213 0.04609667993652 341 883298
SGTC_1213 1315-0166 115 µM 1.68141941021574 0.0479402952382481 no 214 0.046340738969843 289 768401
SGTC_3027 9089541 49.47 µM 1.67026747728675 0.0490624512952114 no 215 0.0474332273956206 359 9943819
SGTC_1112 tnp00069 1.16933 µM 1.66718877575345 0.0493759117779384 no 216 0.047738436948245 377 145826
SGTC_1728 st035614 33.7865 µM 1.6651508505864 0.0495842827766496 no 217 0.0479413318957822 421 15945546
SGTC_13 0199-0087 65 µM 1.66054035666159 0.0500582800370317 no 218 0.0484028981247211 337 4589825
SGTC_135 0933-0004 26.348 µM 1.65672568858367 0.0504531849705814 no 219 0.0487874734645495 348 21230617 YGL099W LSG1
SGTC_246 cycloheximide 667 µM 1.65484205087075 0.0506490977084818 no 220 0.0489782707921327 282 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2475 5812728 15.03 µM 1.65392833669871 0.0507443489727789 no 221 0.0490710371585278 364 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1224 0823-0416 294 µM 1.64742400745204 0.051426529091003 no 222 0.0497354620666447 334 3598164
SGTC_1170 0310-0127 64.8 µM 1.64711872371233 0.0514587258729616 no 223 0.0497668226449386 370 774975
SGTC_3056 9094900 49.47 µM 1.64320109179608 0.0518733237531141 no 224 0.0501706670405231 360 25236784
SGTC_2986 9022445 71.43 µM 1.64288129579431 0.0519072842010928 no 225 0.050203747825179 346 6459286
SGTC_272 doxorubicin 8.13 µM 1.63763312801768 0.0524671365497144 no 226 0.0507491240329139 396 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1942 st076330 65.2 µM 1.63674761161649 0.0525620705817592 no 227 0.0508416080967846 336 24208414
SGTC_3284 9108171 64.8615 µM 1.63581580878356 0.0526621140252126 no 228 0.0509390711972459 305 8687505
SGTC_3119 9125183 49.47 µM 1.63184860668892 0.0530897467388873 no 229 0.0513556914254902 225 22695334
SGTC_2909 7941780 10.49 µM 1.62768140467345 0.0535418982113313 no 230 0.0517962290206637 351 1243215
SGTC_582 0987-0078 156 µM 1.62310074265077 0.0540424253482223 no 231 0.0522839354493064 500 1625765
SGTC_2415 st077333 57.7 µM 1.62111903315073 0.0542601105254431 no 232 0.0524960563979695 437 2766255
SGTC_677 0929-0063 136 µM 1.61244396765235 0.0552212190542284 no 233 0.0534326818513473 283 1539583
SGTC_2744 captopril 92.04 µM 1.61087439699547 0.0553965393609644 no 234 0.0536035507118723 260 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3317 9138495 8.753 µM 1.61020125234911 0.0554718638408968 no 235 0.0536769640537686 377 17020139
SGTC_2603 homopterocarpin 100 µM 1.60962242305166 0.0555366991306558 no 236 0.053740155000154 410 101795 A weak amylase inhibitor.
SGTC_1360 1598-0022 39.8 µM 1.60952465502068 0.0555476561355789 no 237 0.0537508341755517 450 761525
SGTC_819 1013-0258 27.7 µM 1.60709117535246 0.0558209299588792 no 238 0.0540171844217094 388 5753198
SGTC_1968 st069590 43.6 µM 1.60557397385829 0.0559918441008414 no 239 0.054183773845135 340 6384066
SGTC_1809 st050081 57.6 µM 1.60396079402272 0.0561740227725035 no 240 0.0543613474188077 348 5036894
SGTC_3211 9128781 49.47 µM 1.59690438121151 0.0569764128083787 no 241 0.0551435115253246 413 17194361
SGTC_1505 k297-0037 20.6 µM 1.59666754407689 0.0570034994535562 no 242 0.0551699170029483 383 4089396
SGTC_2616 abietic acid 100 µM 1.59282449056149 0.0574444411561554 no 243 0.055599784709628 392 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2623 humulene 100 µM 1.58879149655718 0.0579100570638566 no 244 0.0560537368506228 316 6187145 An anti-inflammatory.
SGTC_553 k007-0256 45.7 µM 1.58867349628439 0.057923724929908 no 245 0.0560670627962151 390 6287000
SGTC_656 4090-1979 187 µM 1.58719263748857 0.0580954671419528 no 246 0.0562345108806049 411 22330961
SGTC_1941 st076221 61.8 µM 1.58688339784215 0.0581313815814466 no 247 0.0562695278634922 455 2828568
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.5836119846677 0.0585123858760178 no 248 0.0566410224730609 407 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_830 4076-0286 57.8 µM 1.58304328773742 0.0585788186252106 no 249 0.056705799171185 562 6866659
SGTC_3147 9097027 49.47 µM 1.58068447131532 0.0588549978771119 no 250 0.0569751003573852 369 25236841
SGTC_2344 7990960 76.95 µM 1.57772978866838 0.0592023837682863 no 251 0.0573138498787641 356 140813
SGTC_1715 st032160 10.2275 µM 1.57393958995713 0.0596503543119661 no 252 0.0577507080527262 367 5289825
SGTC_2789 5281112 71.43 µM 1.5726890046088 0.0597987446760445 no 253 0.0578954235349548 404 765948
SGTC_2147 5545932 89.7195 µM 1.57156344868321 0.0599325465789887 no 254 0.0580259144303035 351 797404
SGTC_2870 9038528 12.99 µM 1.5710835761086 0.0599896632928825 no 255 0.0580816185045035 353 6463316
SGTC_665 3914-0008 307 µM 1.56931014612378 0.0602011152924269 no 256 0.0582878446504302 391 1069549
SGTC_1680 diphenhydramine 100 µM 1.56895295834486 0.0602437744963961 no 257 0.0583294503095822 398 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1893 st059353 36.1 µM 1.56775155072666 0.0603874331680657 no 258 0.0584695629005964 415 3112488
SGTC_737 1950-0117 57.9 µM 1.5592245018764 0.0614147744140468 no 259 0.0594716267949631 387 5393513
SGTC_2536 dehydroabietamide 32.04 µM 1.55823415921842 0.0615349708036665 no 260 0.0595888751015752 423 3983547
SGTC_3135 9127742 49.47 µM 1.55598222029287 0.0618089690225189 no 261 0.0598561601482062 359 3643468
SGTC_853 0419-0306 21 µM 1.55564331970879 0.061850286098767 no 262 0.0598964657954 362 762713
SGTC_142 0335-0849 62.6745 µM 1.5503772337482 0.0624950748345383 no 263 0.0605254997907874 541 3889043 YPR107C YTH1
SGTC_869 0564-0080 44.1 µM 1.5470721782377 0.0629024206186546 no 264 0.0609229209385141 428 6843321
SGTC_1466 k213-0079 57.5 µM 1.54187327953532 0.063547363621805 no 265 0.061552195153774 416 3657981
SGTC_3101 9120531 49.47 µM 1.53804963135345 0.0640249769440985 no 266 0.0620182400286163 420 24824904
SGTC_2041 5107442 45.335 µM 1.5372275288143 0.0641280297165512 no 267 0.0621188006189275 406 793005
SGTC_756 0508-1999 28.3 µM 1.53590331917745 0.0642942940402795 no 268 0.0622810469877316 392 6753853
SGTC_1023 4482-3888 16 µM 1.52976110068369 0.0650698793911203 no 269 0.0630379367137332 387 3303168
SGTC_1830 st055982 50.3 µM 1.52853323122123 0.0652257912532632 no 270 0.0631900996392852 419 455313 An antimicrobial agent.
SGTC_2716 st080858 38.6235 µM 1.51761673809411 0.0666247127135917 no 271 0.0645555223951715 372 5296050
SGTC_19 0279-0214 38.434 µM 1.51708428612169 0.0666935344822033 no 272 0.0646227025503961 507 3566274 YBR002C RER2
SGTC_160 3453-0671 289.699 µM 1.51603162739609 0.0668297571557956 no 273 0.0647556776475255 432 5322268
SGTC_66 0109-0187 42.4 µM 1.51072462908784 0.06751980701217 no 274 0.0654293123405631 407 759417
SGTC_207 4185-0010 4.486 µM 1.50924774497135 0.0677128169402594 no 275 0.0656177415258377 501 3761753
SGTC_315 k915-0449 187 µM 1.5045894563668 0.0683243887375228 no 276 0.0662148293362508 490 20970215 YNL149C PGA2
SGTC_1223 0764-0573 147 µM 1.50045569938043 0.0688706580772341 no 277 0.0667482003501097 467 1609797
SGTC_2671 danthron 100 µM 1.50036023876572 0.0688833127032898 no 278 0.0667605566146102 412 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1701 st028638 40.4 µM 1.4991543795865 0.069043320407569 no 279 0.0669167934689609 406 3490878
SGTC_1726 st035556 14.5795 µM 1.49890133088014 0.0690769342465161 no 280 0.0669496155404452 474 5919439
SGTC_192 3455-0609 60.9 µM 1.49715767839533 0.0693088960584131 no 281 0.0671761173076976 405 3769639
SGTC_844 0330-0132 15.3 µM 1.49642032561058 0.0694071680073671 no 282 0.0672720780612799 412 2828079
SGTC_1161 k007-0610 110 µM 1.49620090845358 0.069436431912303 no 283 0.0673006539549113 544 5843850
SGTC_2725 haloperidol 53.21 µM 1.49243893238994 0.0699396501660604 no 284 0.06779205757589 429 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1692 fluoroquinolonic acid 71 µM 1.48974079999841 0.0703022887789818 no 285 0.0681462011647541 383 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_996 3970-0799 1.8 µM 1.48963374687634 0.070316706867043 no 286 0.0681602818294801 581 6615648 YGL040C HEM2
SGTC_97 0535-0701 19.132 µM 1.48703961874318 0.0706667838144821 no 287 0.0685021737025464 396 2832013 YGL099W LSG1
SGTC_2328 6201408 200 µM 1.48013912952155 0.0716045231303531 no 288 0.0694180604546174 420 2890418
SGTC_1151 3909-8316 15.3 µM 1.47693916824307 0.072042607786236 no 289 0.069845972192191 445 800431
SGTC_1791 st048313 56.1 µM 1.47683972262422 0.0720562550488305 no 290 0.0698593029129181 378 1204976
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.47430006915094 0.0724054523915643 no 291 0.0702004082879467 403 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1530 rhein 70.4 µM 1.46796728146925 0.0732818447568436 no 292 0.071056555276642 455 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1707 st032323 6.317 µM 1.46754017911572 0.0733412421462142 no 293 0.071114583799176 466 3132057 YMR211W DML1
SGTC_1215 3852-0577 11.2 µM 1.46563371076072 0.0736068250300729 no 294 0.0713740511264541 490 2884876
SGTC_3094 9117742 49.47 µM 1.46415795024496 0.0738129120372908 no 295 0.0715753982524386 487 17149698
SGTC_1826 st055655 41.6 µM 1.46363513306205 0.0738860281077283 no 296 0.0716468338839604 456 676168
SGTC_2506 ethyl hematommate 54.16 µM 1.46266870925174 0.0740213283336676 no 297 0.0717790261209555 371 3940691 An allergen.
SGTC_1870 st057514 26.5 µM 1.45962126228337 0.0744492133927789 no 298 0.0721970961828944 435 5393161
SGTC_2144 5628481 200 µM 1.45954878657962 0.0744594124802971 no 299 0.0722070615782796 400 2818399
SGTC_1342 1486-1464 234 µM 1.45643395079453 0.0748987541057102 no 300 0.0726363479454026 460 3253938
SGTC_1019 4262-0212 3.4 µM 1.45507988491443 0.0750903580529556 no 301 0.0728235735925319 539 4677213
SGTC_3288 9119690 36.221 µM 1.45291652734406 0.0753972542747111 no 302 0.073123465774574 398 17595618 YKL019W RAM2
SGTC_118 0083-0097 135.343 µM 1.45288647855785 0.0754015237491539 no 303 0.0731276378864222 687 5207356
SGTC_2050 5263056 171 µM 1.45210144129416 0.0755131308794031 no 304 0.0732367006282584 523 763468 YGL055W OLE1
SGTC_1156 4092-0367 4.88 µM 1.45073974085346 0.0757070195154902 no 305 0.0734261724296201 465 1357585
SGTC_298 1391-0729 10 µM 1.44518711326219 0.0765015700042535 no 306 0.074202667556689 418 3237558
SGTC_1629 st005085 44.9 µM 1.44506338043566 0.0765193474684888 no 307 0.0742200418652271 458 24207091
SGTC_2285 7945142 200 µM 1.44501713287636 0.0765259929495138 no 308 0.074226536649828 443 2970608
SGTC_2052 5265182 7.135 µM 1.44357403641596 0.0767335774104057 no 309 0.0744294163304008 463 1239884
SGTC_984 1492-0255 2.91 µM 1.4423547064393 0.0769093073336451 no 310 0.0746011672409397 421 1585198
SGTC_1825 st052143 62.6 µM 1.43881331302371 0.07742142779494 no 311 0.0751017117044802 392 674173
SGTC_2541 muurolladie-3-one 83.07 µM 1.43822460854914 0.0775068107520879 no 312 0.0751851675252056 448 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1928 4'-methoxychalcone 40.3 µM 1.43784457961658 0.0775619663462604 no 313 0.0752390786640668 453 641818
SGTC_3347 9188721 44.724 µM 1.43528994398391 0.0779335078346575 no 314 0.0756022460659438 411 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_862 0452-0056 10.2 µM 1.43348081054735 0.0781974406328762 no 315 0.0758602395040835 430 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1871 st057448 67.3 µM 1.4270955145299 0.079134406097683 no 316 0.0767761826162553 487 691747
SGTC_2696 st077691 74.316 µM 1.42493547513429 0.0794532827994174 no 317 0.0770879269195831 428 757133
SGTC_1693 xanthone 101.9 µM 1.41253687114884 0.0813024688955692 no 318 0.078895971057012 494 7020 An insecticide.
SGTC_3045 9092950 49.47 µM 1.4123121549642 0.0813362811571033 no 319 0.0789290344980204 506 44120432
SGTC_3330 9141424 71.43 µM 1.40800061127409 0.0819870800130293 no 320 0.0795654444942378 515 27261020
SGTC_463 ikarugamyin 104 µM 1.40641974044618 0.0822266824793171 no 321 0.0797997609227403 360 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_731 3966-0296 387 µM 1.4042905355032 0.082550225445641 no 322 0.0801161757324988 468 660956
SGTC_1265 0819-1001 68.8 µM 1.40292344024113 0.0827584667706286 no 323 0.0803198350886596 463 3106768
SGTC_3343 9148379 18.9835 µM 1.39954172779598 0.0832752804609745 no 324 0.0808252971830987 463 1955036
SGTC_151 3013-0144 2.285 µM 1.39906875464486 0.0833477560590269 no 325 0.0808961831524601 502 906558 YHR107C CDC12
SGTC_3174 9107204 49.47 µM 1.39884212281621 0.0833825005736438 no 326 0.0809301658027779 480 3938802
SGTC_2363 9053361 176 µM 1.39598253977701 0.0838218338245191 no 327 0.0813598765417607 501 6469797 YMR079W SEC14
SGTC_1128 3448-9350 235 µM 1.39489943919608 0.083988689644458 no 328 0.0815230831365114 428 619386
SGTC_3252 9135871 49.47 µM 1.39392162760033 0.0841395393888652 no 329 0.0816706362416304 474 17682838
SGTC_779 1360-0071 233 µM 1.38815261814032 0.0850336829588212 no 330 0.0825452884216799 525 7566
SGTC_2473 5854593 8.94 µM 1.38734442802405 0.0851595116462342 no 331 0.0826683808882393 452 2872951
SGTC_1299 1079-1439 3.74 µM 1.38553329352266 0.0854419972925697 no 332 0.0829447297224549 478 323161
SGTC_3333 9141820 12.094 µM 1.38109464429763 0.0861372676070467 no 333 0.0836249310532074 447 1939433
SGTC_2071 5230951 39.92 µM 1.3808914913424 0.0861691904908259 no 334 0.083656163256241 513 1799272
SGTC_2985 9022375 71.43 µM 1.37902921165007 0.0864622363831502 no 335 0.0839428737485024 504 4939335
SGTC_1756 st041558 35.5 µM 1.3780514526273 0.0866163932528034 no 336 0.0840937014326622 535 3955792
SGTC_1901 st060216 58.6 µM 1.37708401982051 0.0867691241603269 no 337 0.0842431363615805 500 688792
SGTC_2741 miltefosine 3.04 µM 1.37696215699918 0.0867883771950063 no 338 0.0842619740802314 398 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2736 butenafine 14.65 µM 1.37668717310581 0.0868318334650984 no 339 0.0843044930752141 539 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.3763788593529 0.0868805762523064 no 340 0.0843521847972545 490 390807
SGTC_543 3844-1095 191 µM 1.37315977301123 0.0873907184351229 no 341 0.0848513411446756 530 4230703
SGTC_511 blebbistatin 171 µM 1.37312260288412 0.0873966219719034 no 342 0.0848571177056013 478 3476986 A myosin inhibitor.
SGTC_1775 st081588 35.1725 µM 1.36815665387537 0.0881880169171752 no 343 0.0856315231544304 546 1426443 YGL099W LSG1
SGTC_913 3487-1245 167 µM 1.36496987306162 0.0886986824155898 no 344 0.0861312595718673 513 4016153
SGTC_741 4582-0002 126 µM 1.36301395139464 0.0890131977339961 no 345 0.0864390568683098 511 2912688
SGTC_734 2023-0417 80 µM 1.36258721941602 0.0890819270944982 no 346 0.08650631950365 512 3935732
SGTC_2292 7671323 168.05 µM 1.36231901023146 0.0891251450165372 no 347 0.086548615373413 511 937504
SGTC_1713 st033146 12.748 µM 1.35825357264372 0.0897821418426817 no 348 0.0871916183278061 516 674619
SGTC_2219 9098279 200 µM 1.3579436722485 0.0898323707196621 no 349 0.0872407791237823 477 902349
SGTC_577 r071-0003 38.6 µM 1.3562665671347 0.0901045595345882 no 350 0.0875071844287534 657 4568517 YMR134W ERG29
SGTC_3078 9116413 49.47 µM 1.35410380856769 0.0904564722910879 no 351 0.0878516306540589 463 17177322
SGTC_3248 9135562 49.47 µM 1.3520574407534 0.0907903851799949 no 352 0.0881784703179245 538 17650701
SGTC_1457 k015-0032 57.3 µM 1.35186739017034 0.0908214427455794 no 353 0.0882088705591976 517 4302660
SGTC_1119 parthenolide 318.541 nM 1.35084134646691 0.0909892522812238 no 354 0.0883731301109485 595 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1044 1222-0021 1.78 µM 1.35041186158133 0.0910595628172375 no 355 0.0884419540689754 524 4306703
SGTC_1943 st076331 65.2 µM 1.34941566508609 0.0912228042634419 no 356 0.0886017459842186 524 24208415
SGTC_2362 9071156 126 µM 1.34900329696222 0.0912904403100076 no 357 0.0886679535548045 502 653133
SGTC_3354 9151612 71.43 µM 1.34543134724738 0.0918778630458934 no 358 0.0892429888994613 544 27261949
SGTC_2044 5102272 200 µM 1.34338429787802 0.092215768719323 no 359 0.0895737843183156 456 592666
SGTC_64 000l-0018 272.079 µM 1.33718204863294 0.0932451866397124 no 360 0.0905816100391362 643 6811119
SGTC_2973 9094665 17.96 µM 1.33430278647601 0.0937259476372382 no 361 0.0910523223862475 571 25237061 YIL048W NEO1
SGTC_2887 9044784 58.44 µM 1.33361624109845 0.0938408523696802 no 362 0.0911648287529318 539 6465546
SGTC_1485 3909-9022 254 µM 1.32871477433492 0.0946642164198801 no 363 0.091971044363719 534 714516
SGTC_3234 9132280 49.47 µM 1.3272129623609 0.0949175581797333 no 364 0.0922191228471314 551 17612295
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.32559757356079 0.0951906165174732 no 365 0.0924865151907864 548 3256 An antibiotic and ribosome inhibitor.
SGTC_1243 0416-0003 5.65 µM 1.32482979146632 0.0953206017044122 no 366 0.0926138056804789 529 2141977
SGTC_349 k015-0014 24 µM 1.31853342085787 0.0963915077748951 no 367 0.0936625724198382 511 2196908
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.31770812469729 0.096532529487021 no 368 0.0938006868583871 579 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2859 9028643 45.46 µM 1.31740996323696 0.0965835148028102 no 369 0.0938506215360875 486 17151580
SGTC_1439 4092-1168 46 µM 1.31486723315808 0.0970191230439583 no 370 0.0942772633748773 529 2886240
SGTC_2640 pentamidine 10.38 µM 1.31403454604078 0.0971620879782353 no 371 0.0944172894812564 595 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1357 1503-1303 39.5 µM 1.3115592194802 0.0975879922265284 no 372 0.0948344501455896 595 292895
SGTC_3059 1327-0034 3 µM 1.31011783675245 0.0978366261371812 no 373 0.0950779876286049 549 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2278 7948257 134.34 µM 1.30876482633512 0.0980704383153819 no 374 0.0953070124867455 531 1247028
SGTC_2096 5468907 200 µM 1.30707597277412 0.098362861288306 no 375 0.0955934552900841 523 759785
SGTC_2332 7982454 138.89 µM 1.30370054508057 0.0989492250577299 no 376 0.0961678517571375 564 2981748
SGTC_1272 0839-0021 27 µM 1.30156900785416 0.0993208208067603 no 377 0.0965318800598179 565 5027250
SGTC_1383 3049-0032 20.7 µM 1.30151925589316 0.0993295063478018 no 378 0.0965403888756527 556 712864
SGTC_2379 9035213 200 µM 1.29963462062072 0.0996589290967874 no 379 0.0968631140071052 595 646551
SGTC_876 0720-0963 56.8 µM 1.29931152609839 0.0997154841128989 no 380 0.0969185201934714 588 765861
SGTC_3337 9144342 33.5465 µM 1.29677976422526 0.100159459956109 no 381 0.0973534876140897 537 17682949
SGTC_1731 st035964 63 µM 1.2956355625171 0.100360582712595 no 382 0.0975505355099398 536 6739575
SGTC_475 α-linolenic acid 10 µM 1.29284276783764 0.100852725199051 no 383 0.0980327226174294 569 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2955 9076254 12.21 µM 1.29273457867416 0.100871825488209 no 384 0.098051436982209 514 16459619
SGTC_624 k048-0052 28 µM 1.29056454568491 0.101255491793423 no 385 0.0984273583341092 533 6835531
SGTC_1283 0922-0125 16.4 µM 1.28945005447206 0.101452948909142 no 386 0.0986208346975879 596 3360884
SGTC_407 eburnamonine 100 µM 1.28877343343505 0.101572964246644 no 387 0.0987384322571611 477 3195
SGTC_405 ebelactone b 50 µM 1.28794432961259 0.101720167069147 no 388 0.0988826713900632 576 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3106 9121286 49.47 µM 1.28534772918531 0.102182183967849 no 389 0.099335399157037 495 15943471
SGTC_3113 9123498 49.47 µM 1.28492920191705 0.102256795765561 no 390 0.0994085126607254 541 8897275
SGTC_331 k048-0133 24.5 µM 1.28467606607707 0.102301942088502 no 391 0.0994527526372213 493 6813582
SGTC_2198 6589944 200 µM 1.28338946229831 0.102531629663392 no 392 0.0996778319266922 450 5290268
SGTC_1864 st057645 30.4 µM 1.28287962673109 0.102622750365992 no 393 0.0997671257752735 503 688666
SGTC_549 1661-1316 519 µM 1.28016967800856 0.103108075836388 no 394 0.100242733752732 574 2857282
SGTC_2519 cryptotanshinone 88.04 µM 1.2788152974227 0.10335125603193 no 395 0.100481052844882 539 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2369 9071472 200 µM 1.27615408829222 0.103830290693877 no 396 0.100950527325064 563 17296037
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.27465129911312 0.104101512845837 no 397 0.101216345792721 600 688751
SGTC_289 k017-0060 526 µM 1.27320982562815 0.104362151083731 no 398 0.101471797429888 522 5512909
SGTC_850 0388-0143 75.9 µM 1.27228433287503 0.104529741993451 no 399 0.101636056557421 547 67273
SGTC_2964 9083345 53.42 µM 1.27215766762324 0.10455269406402 no 400 0.101658552526124 521 17741579
SGTC_3346 9158254 43.5805 µM 1.26889064391205 0.105145949206018 no 401 0.102240034861684 566 17639500
SGTC_3040 9091894 49.47 µM 1.26486688336333 0.105879962323758 no 402 0.102959525257818 499 25236966
SGTC_1315 1237-0019 3.69 µM 1.26244816463159 0.106322962509926 no 403 0.103393783624778 588 825140
SGTC_2387 9077560 195.08 µM 1.26148338887998 0.106500038851695 no 404 0.1035673705305 573 5303272
SGTC_1319 1306-0155 43.7 µM 1.25950310981605 0.10686416896185 no 405 0.103924333840119 633 3122360
SGTC_516 3992-2719 87.3 µM 1.25859708301179 0.107031066689965 no 406 0.104087950590489 531 5350887 YDR037W KRS1
SGTC_3328 9140624 29.0385 µM 1.25703810338443 0.1073186837177 no 407 0.104369919207648 590 4904392
SGTC_1672 st016598 6.51 µM 1.25541622335637 0.107618496204938 no 408 0.104663851503224 594 4665860 YNL267W PIK1
SGTC_2286 7945697 125 µM 1.25456318812504 0.107776425921373 no 409 0.104818686924247 575 1245733
SGTC_681 1642-0006 26.6 µM 1.2518871230194 0.108272951965779 no 410 0.105305498793097 533 4446530
SGTC_2444 5485484 36.41 µM 1.25124250702589 0.10839280182696 no 411 0.105423007098351 607 6790631
SGTC_644 1498-1197 63.3 µM 1.24610613674901 0.109351190350949 no 412 0.106362716084 621 6741615
SGTC_1402 3909-7673 35.9 µM 1.23556376889213 0.111337312167545 no 413 0.108310379582186 576 5328014
SGTC_3260 9137109 49.47 µM 1.23382437020305 0.111667470997687 no 414 0.108634178131719 479 17478346
SGTC_2398 5228213 48.84 µM 1.23312525348853 0.111800368914074 no 415 0.108764518483982 688 80771 YMR134W ERG29
SGTC_2135 5326629 150.42 µM 1.23261177468828 0.11189805019948 no 416 0.108860320892876 547 5020077
SGTC_204 PMA1.184 62.41 µM 1.23148573468511 0.112112475277912 no 417 0.109070624400572 640 2252213 YGL008C PMA1
SGTC_1664 st014217 9.02 µM 1.22879992746714 0.112625102901878 no 418 0.109573414371582 639 3982782
SGTC_946 3434-1334 87.4 µM 1.22751876022935 0.112870222222732 no 419 0.109813837561173 576 4047976
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.22695853943486 0.112977526055715 no 420 0.109919087206577 666 688788
SGTC_2341 7987486 176.74 µM 1.22404373311458 0.113536998553006 no 421 0.110467865092946 630 1258686
SGTC_3243 9134147 49.47 µM 1.22366485893481 0.11360986508273 no 422 0.110539340681409 614 24282180
SGTC_822 1487-0950 154 µM 1.22173442625879 0.113981650986401 no 423 0.110904036552692 595 1958375
SGTC_2202 7226349 200 µM 1.22091265956134 0.114140179441508 no 424 0.111059545367069 562 844334
SGTC_2999 9069765 71.4286 µM 1.21707910811609 0.114881791653407 no 425 0.111787059339373 634 2097066
SGTC_727 3032-0951 202 µM 1.21689553890727 0.11491738947076 no 426 0.111821981588988 564 3652836
SGTC_985 1493-0307 8.71 µM 1.21419171739719 0.115442624709771 no 427 0.112337261300149 559 3278274
SGTC_2424 5537928 59.2 µM 1.21358447444471 0.115560819892378 no 428 0.112453219326234 658 5382802
SGTC_3158 9100007 49.47 µM 1.21219222761434 0.115832134524991 no 429 0.112719403000341 530 19297233
SGTC_895 0964-0006 13.7 µM 1.21060573000491 0.116141854907161 no 430 0.113023273577309 602 6738897
SGTC_1783 st039459 87.517 µM 1.20852810104597 0.116548343513078 no 431 0.11342209672805 682 729761
SGTC_3287 9117173 37.0625 µM 1.20592403255127 0.117059253656694 no 432 0.113923391609912 548 2789709
SGTC_674 0498-0004 451 µM 1.20284759149909 0.117664884208351 no 433 0.114517652099375 595 4231473
SGTC_360 0957-0399 1.01 µM 1.20235746471878 0.117761575385294 no 434 0.114612530790863 647 6752301 YPR165W RHO1
SGTC_1765 st044815 90.4 µM 1.20146262140316 0.117938253204009 no 435 0.114785898745705 611 645695
SGTC_1550 gossypolone 36.6 µM 1.20077851283249 0.118073449989583 no 436 0.114918564494918 640 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_266 formosanin C 406 nM 1.20054405294604 0.11811981027806 no 437 0.114964057210819 638 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.19958332462552 0.118309911729911 no 438 0.115150602998477 687 66535 A nucleotide analog.
SGTC_62 0180-0423 3.232 µM 1.1960623826725 0.119008456974184 no 439 0.11583610795541 607 30102 YGL099W LSG1
SGTC_750 4073-0104 132 µM 1.19474919359934 0.11926973426768 no 440 0.116092517990652 508 22330957
SGTC_2946 9065502 71.43 µM 1.19204485491859 0.119809074903043 no 441 0.116621828931139 460 16489101
SGTC_2192 5915882 198.485 µM 1.18864183761419 0.120490197127521 no 442 0.117290318495907 573 2876149
SGTC_590 k048-0076 22.4 µM 1.18838479973285 0.120541754428923 no 443 0.117340921097296 625 6832814
SGTC_1252 0493-0875 34.8 µM 1.18732095796171 0.120755307669801 no 444 0.117550522197772 609 3960963
SGTC_949 1165-0505 146 µM 1.18719555458706 0.120780498400554 no 445 0.117575246976358 675 6244267
SGTC_2406 ethylparaben 405.7 µM 1.18380272189899 0.121463446722264 no 446 0.118245582259966 540 8434 A possible steroid mimic.
SGTC_800 3448-7362 155 µM 1.18128981479773 0.121971020389749 no 447 0.118743806024672 879 15991913
SGTC_576 1073-0113 22.7 µM 1.1795704861607 0.12231915900549 no 448 0.119085543563284 813 5439563
SGTC_3096 9117468 49.47 µM 1.17788483130597 0.122661155725094 no 449 0.119421261546303 522 41316311
SGTC_3332 9141069 11.198 µM 1.17683720110758 0.12287404349268 no 450 0.119630245598065 571 17332883
SGTC_1118 chelidonine 707.474 nM 1.17585960302834 0.123072933674654 no 451 0.1198254919929 697 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3226 9131256 49.47 µM 1.17236239427974 0.123786280270961 no 452 0.120525795463149 514 17178073
SGTC_2612 dictamnine 15.46 µM 1.1723088211314 0.123797230369866 no 453 0.120536545659901 623 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_472 calcifediol 10 µM 1.17168152381718 0.123925497439378 no 454 0.120662471825058 574 5283731 A vitamin D metabolite.
SGTC_1600 coumarin 106 71.1 µM 1.16914704797923 0.124444683170036 no 455 0.121172195563734 681 100336 A hepatotoxic, DNA x-linker.
SGTC_1696 st025591 34.7925 µM 1.16670741077209 0.124945876053798 no 456 0.121664274514252 661 2787147
SGTC_2084 5306078 60.6385 µM 1.165432747656 0.125208299725968 no 457 0.121921934022114 627 679340
SGTC_645 0845-0943 5.41 µM 1.16215097377497 0.125885711303397 no 458 0.122587072496329 619 1885106
SGTC_1124 fisetin 1.16336 µM 1.16024430508693 0.12628045058283 no 459 0.122974676572548 597 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1297 1068-0111 14.1 µM 1.15955364057617 0.12642365206231 no 460 0.123115292584132 626 767057
SGTC_3217 9129673 49.47 µM 1.15876632747929 0.126587030484571 no 461 0.123275723199586 631 17248312
SGTC_452 diindolylmethane 8 µM 1.15731675830305 0.126888220765392 no 462 0.123571484603244 604 3071 Inhibits expression of several cancer promoting factors.
SGTC_2324 6149169 200 µM 1.15541674440527 0.127283759046162 no 463 0.123959904112687 618 2888231
SGTC_1195 1502-0147 41.1 µM 1.15484296584832 0.127403374706899 no 464 0.124077369358896 681 817940
SGTC_1465 k213-0056 144 µM 1.15454228116817 0.12746608967543 no 465 0.124138957299506 643 24048857 YMR208W ERG12
SGTC_299 1273-0059 1.44 µM 1.15381955009696 0.127616920300959 no 466 0.124287078649711 628 2848077
SGTC_1590 st077108 57.8 µM 1.15311183267822 0.127764737843855 no 467 0.124432242747445 640 5489485
SGTC_1503 4585-0012 61.3 µM 1.14978414818184 0.128461370370063 no 468 0.125116392872406 640 2922052
SGTC_3118 9124250 49.47 µM 1.14805268891523 0.128824882860286 no 469 0.125473406723346 588 1504786
SGTC_2237 6667747 47.222 µM 1.14655688668752 0.129139494140548 no 470 0.125782401788779 630 729940 YDL015C TSC13
SGTC_3295 9122362 53.5725 µM 1.14552616460459 0.129356595109916 no 471 0.125995631657231 632 4730473
SGTC_36 0335-0881 14.2 µM 1.14545871641518 0.129370810532529 no 472 0.126009593732438 714 23828853
SGTC_2108 5365811 200 µM 1.14441470477332 0.129590985152428 no 473 0.126225846374824 675 780283
SGTC_455 paf C-16 10 µM 1.14188475144275 0.130125610507768 no 474 0.126750963867599 644 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1886 st057356 49.9 µM 1.14126699824853 0.130256384564255 no 475 0.126879415540624 634 24207747
SGTC_2814 7977482 42.97 µM 1.13989353764105 0.130547462366806 no 476 0.127165328847303 724 6456762
SGTC_2848 9016370 25.97 µM 1.13888781262784 0.130760890952742 no 477 0.127374974741774 738 7894410
SGTC_2911 7942208 15.64 µM 1.1382164279685 0.130903502124722 no 478 0.12751506028269 632 1243384
SGTC_2175 5807670 165.306 µM 1.13794545308436 0.130961091284579 no 479 0.127571629981902 649 241186
SGTC_1487 3970-0795 2.82 µM 1.13651316299182 0.131265780717108 no 480 0.127870929902011 707 3765103
SGTC_2303 7774051 200 µM 1.13569620443007 0.131439790459906 no 481 0.128041864825942 630 2953184
SGTC_2177 5811945 192 µM 1.13429910455928 0.131737737473988 no 482 0.128334552329339 664 5343475
SGTC_1855 st056195 39.6 µM 1.12871352445095 0.13293357833578 no 483 0.129509351080613 659 4028379
SGTC_2663 amphotericin b 100 µM 1.12633009741106 0.133446124486491 no 484 0.130012911386141 625 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2137 5261020 140 µM 1.12465742998431 0.133806635403426 no 485 0.130367113709401 659 763655
SGTC_3138 9097216 49.47 µM 1.12316944246031 0.13412790434667 no 486 0.130682768952753 670 25237486
SGTC_1418 3966-3099 2.4 µM 1.12174372123357 0.134436226206061 no 487 0.130985710595401 703 740335
SGTC_2586 curcumin 80 µM 1.11701383393088 0.135462579574509 no 488 0.131994205125844 786 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2906 7926292 26.41 µM 1.11674217864168 0.13552168954202 no 489 0.132052288947635 690 2966319
SGTC_1900 st060200 72.8 µM 1.11364911572599 0.136195960979075 no 490 0.132714873391363 695 688945
SGTC_2434 5670830 169.91 µM 1.11277170095906 0.136387650068392 no 491 0.132903246117657 687 1549830
SGTC_1659 st012954 42.1 µM 1.11256222482075 0.136433441666991 no 492 0.132948245889368 676 24207262
SGTC_1862 st057513 3.81 µM 1.1112796190646 0.136714049312398 no 493 0.133224004655909 678 5393163
SGTC_208 k072-0098 12.366 µM 1.10884865851247 0.137246975290641 no 494 0.133747737688674 782 5948901
SGTC_2340 7987427 183.45 µM 1.1088046492978 0.137256636244398 no 495 0.133757232184358 687 2239331
SGTC_1024 4507-0395 26 µM 1.10805746840264 0.137420729144806 no 496 0.13391849881466 670 4201836
SGTC_2270 7924575 90.91 µM 1.10661757958476 0.137737329464979 no 497 0.134229651726751 728 1262135
SGTC_141 0443-0274 32.331 µM 1.10564539497526 0.137951373045395 no 498 0.134440016650747 805 1627241
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.10559205958191 0.137963122334059 no 499 0.134451564107671 750 23847180
SGTC_2187 6125751 200 µM 1.10486412488729 0.138123547775266 no 500 0.134609234738585 710 874498
SGTC_2575 plumbagin 510 nM 1.10296149960936 0.138543457243927 no 501 0.135021942477264 684 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1839 st053978 48 µM 1.1001847993846 0.139157834641758 no 502 0.135625806089991 689 3788398
SGTC_852 0418-0143 439 µM 1.09988554639408 0.139224158381823 no 503 0.135690996483192 791 5369229
SGTC_1398 3558-0053 112 µM 1.09663828040827 0.139945236364567 no 504 0.13639977325551 632 4532369
SGTC_60 0986-0278 202 µM 1.09619208703388 0.140044514676323 no 505 0.136497360888462 567 3110598
SGTC_2715 st079500 56.4 µM 1.09579610640514 0.140132660689561 no 506 0.13658400640138 658 28246688
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.09530518232995 0.140241993606927 no 507 0.136691478938302 674 641818 YHR062C RPP1
SGTC_2809 7964133 12.99 µM 1.0890539324568 0.141639265788569 no 508 0.138065051577667 725 1253665
SGTC_2195 6536160 144.242 µM 1.08745959119847 0.14199713531921 no 509 0.138416873808577 636 3834386
SGTC_2210 7115885 190.385 µM 1.08694144183518 0.142113572005858 no 510 0.138531344925142 739 2927039
SGTC_319 1348-1596 45.5 µM 1.08589574239223 0.142348754634947 no 511 0.138762560398366 755 5380505
SGTC_397 arbidol 50 µM 1.08567198718202 0.142399112393163 no 512 0.138812069217072 757 131410 A RNA synthesis inhibitor.
SGTC_179 1273-0063 6.77 µM 1.08546615226702 0.142445447697712 no 513 0.138857623553859 657 3108139
SGTC_2430 5571206 200 µM 1.08060443538033 0.143542829661474 no 514 0.139936554361343 808 1731771
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.07735867492133 0.144278628054433 no 515 0.140660029288326 740 688667
SGTC_2802 7925815 54.55 µM 1.07486925243787 0.144844688089363 no 516 0.141216634885132 727 1262923
SGTC_2331 7980721 200 µM 1.0748491302819 0.144849269671974 no 517 0.14122114003799 737 2981221
SGTC_3180 9109287 49.47 µM 1.07372664065163 0.145105002157388 no 518 0.141472608762495 673 18891271
SGTC_3054 9094397 49.47 µM 1.07171246708507 0.145564644967892 no 519 0.141924599696099 744 2598354
SGTC_2665 lovastatin 100 µM 1.07151898801575 0.14560884918269 no 520 0.141968068810451 707 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2413 inermin 26.06 µM 1.07074022992291 0.145786863523114 no 521 0.142143124231072 760 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1565 sinapyl alcohol 95.1 µM 1.06974332564469 0.146014956749979 no 522 0.142367429402452 685 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3299 9121982 43.1275 µM 1.06791607125675 0.146433657552075 no 523 0.142779186171739 739 17594604 YPL160W CDC60
SGTC_2919 7978188 46.38 µM 1.06663669459771 0.146727295812382 no 524 0.143067961879962 753 2980291
SGTC_1268 0828-0275 2.46 µM 1.06660416082935 0.146734768001671 no 525 0.143075310411296 777 745337
SGTC_579 4491-1009 110 µM 1.06614347880122 0.146840602494206 no 526 0.143179393859863 933 1271041
SGTC_499 genistein 192 µM 1.06600491207117 0.146872446048663 no 527 0.143210710712853 714 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3004 9076122 71.4286 µM 1.06443538112293 0.147233458046078 no 528 0.143565756441718 745 44782551
SGTC_732 3970-1727 52.7 µM 1.0632226669178 0.147512804684074 no 529 0.143840492720124 747 1275699
SGTC_1936 st074407 74.3 µM 1.06107101267262 0.148009307913188 no 530 0.14432881508841 777 809813
SGTC_631 k072-0230 41.5 µM 1.06018058584229 0.148215104479799 no 531 0.144531225800286 789 5773147
SGTC_801 0866-0028 10.1 µM 1.05845976242434 0.148613365622572 no 532 0.144922942961881 780 6849771
SGTC_3132 9126706 49.47 µM 1.05838825639218 0.148629930187597 no 533 0.144939235587459 713 850858
SGTC_1436 4092-1007 8.32 µM 1.05571089343864 0.1492510368761 no 534 0.145550159374416 722 2881121
SGTC_653 0203-0016 55.2 µM 1.05506300189613 0.149401597735714 no 535 0.145698255857457 760 295302
SGTC_2552 juarezic acid 87.02 µM 1.05260958099384 0.14997265679561 no 536 0.146259982115688 879 1549512
SGTC_2208 7283366 200 µM 1.04854280940555 0.150922441813154 no 537 0.147194294750896 771 898663
SGTC_2762 leflunomide 42.06 µM 1.04623579198941 0.151463016318362 no 538 0.147726090838615 782 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1655 st012546 55.1 µM 1.04240137528516 0.152364331945736 no 539 0.148612814574209 731 720985 YLR208W SEC13
SGTC_2256 7954252 200 µM 1.0412679497098 0.152631434559654 no 540 0.148875603605538 652 2972920
SGTC_1425 4048-4433 7.33 µM 1.04056620115078 0.152796963952695 no 541 0.149038462223732 817 23734946
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.03736133872337 0.153554444160716 no 542 0.14978374453451 758 2724278 An inhibitor of dopamine biosynthesis.
SGTC_9 0092-0002 10.449 µM 1.03731595518637 0.153565188541178 no 543 0.149794316176697 774 759368
SGTC_1700 st030840 7.9285 µM 1.03721669165095 0.153588690542404 no 544 0.149817440361736 799 5499307
SGTC_2957 9076800 11.52 µM 1.03591065497814 0.153898134425906 no 545 0.150121913155942 684 16459615
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.03344784388979 0.154482778805267 no 546 0.150697183218983 843 368090
SGTC_636 0kpi-0074 126 µM 1.03294658513981 0.154601951726456 no 547 0.150814448140337 731 616434
SGTC_2193 5925765 200 µM 1.03213484113345 0.154795070514272 no 548 0.151004477072254 725 877370
SGTC_3200 9114385 49.47 µM 1.02988098222803 0.155332112330018 no 549 0.151532939609837 706 17018030 YLR208W SEC13
SGTC_2755 lomerizine 42.69 µM 1.02856679908928 0.155645818242858 no 550 0.151841643065855 787 3949 A calcium channel blocker.
SGTC_3195 9113082 49.47 µM 1.02765197439157 0.155864440647981 no 551 0.152056783172125 754 17018038
SGTC_2646 retinol 96.75 µM 1.0269705112208 0.156027426435874 no 552 0.15221717495759 751 445354 A vitamin A analog and teratogen.
SGTC_1973 st070275 50.2 µM 1.02023814093177 0.157643644204809 no 553 0.153807766407195 762 17118334
SGTC_1073 triclabendazole 3.09 µM 1.01871230238544 0.158011470670689 no 554 0.15416978515905 843 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2976 9009005 19.48 µM 1.01763519689787 0.158271462226241 no 555 0.15442567708586 797 2993148
SGTC_1619 st003326 88.7 µM 1.0148732454661 0.158939423662193 no 556 0.155083126553336 750 2849032
SGTC_125 0133-0007 11.75 µM 1.0119256117222 0.159654326114113 no 557 0.155786811180054 870 26541
SGTC_3049 9092223 49.47 µM 1.00952424183488 0.160238293851909 no 558 0.15636164079385 754 8623917
SGTC_3336 9143619 71.43 µM 1.00633102908073 0.161016982692496 no 559 0.157128179532214 854 45595730
SGTC_2759 disulfiram 3.38 µM 1.00632008152305 0.161019656577292 no 560 0.157130811764577 741 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_256 clotrimazole 625 nM 1.00444208139924 0.161478777343058 no 561 0.157582787562779 783 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_102 gallobenzophenone 83.616 µM 1.00052327911805 0.162439565819593 no 562 0.158528668832473 801 70837
SGTC_1591 genipin 88.4 µM 0.999956864308255 0.162578743114255 no 563 0.158665691731157 787 442424 A DNA cross-linking agent.
SGTC_617 3770-0098 35 µM 0.998492430233155 0.162938937780985 no 564 0.15902031665159 759 5962639
SGTC_2729 fluphenazine 10.66 µM 0.99818325330072 0.163015049740787 no 565 0.159095252766814 826 3372 An atypical antipsychotic.
SGTC_1280 0880-0253 10.1 µM 0.995340362096877 0.163715984582485 no 566 0.159785376742812 812 6836607
SGTC_578 3460-0051 92 µM 0.993106905989563 0.164268029167607 no 567 0.160328929426396 926 2876744
SGTC_2947 9072639 7.68 µM 0.990892478115403 0.164816560794554 no 568 0.160869042828846 876 16488146
SGTC_2197 6588183 93.1375 µM 0.987644647086906 0.165623218281239 no 569 0.161663356146176 784 884136
SGTC_2861 9024595 19.48 µM 0.985217182281837 0.166227787378739 no 570 0.162258701216217 747 16482810
SGTC_2264 7948757 110.76 µM 0.982926738812819 0.166799536105883 no 571 0.162821748370777 782 2971411
SGTC_2572 astragaloside iv 100 µM 0.981907949803831 0.167054257070722 no 572 0.16307259946198 804 45006101 An anti-inflammatory agent.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.981334327517931 0.167197786307628 no 573 0.163213949955778 785 689007
SGTC_2669 eugenol 100 µM 0.981256331477766 0.1672173082702 no 574 0.163233175681494 768 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1925 st057770 10.1 µM 0.980741205775766 0.167346278181878 no 575 0.16336018914933 736 5989122
SGTC_314 1671-0008 2.74 µM 0.979275414941723 0.167713612849242 no 576 0.163721957290757 852 3913060
SGTC_269 exalamide 29 µM 0.979142119221579 0.167747043174785 no 577 0.16375488144901 811 3316 A derivative of salicylamide.
SGTC_2280 7785178 200 µM 0.978406809833328 0.167931534555593 no 578 0.163936580742432 796 2954328
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.977727731246671 0.168102033419996 no 579 0.164104501222226 779 6708514
SGTC_2782 7736369 71.43 µM 0.976043677485447 0.168525335700373 no 580 0.164521410125563 853 2950836 YOL077C BRX1
SGTC_595 3909-8003 73.7 µM 0.972920393029825 0.169312214141081 no 581 0.165296434333586 822 699517
SGTC_22 0964-0034 14.468 µM 0.972525635057835 0.169411836843095 no 582 0.165394559049739 861 138402
SGTC_2817 7995342 71.43 µM 0.972084349148266 0.169523246043378 no 583 0.165504293784791 734 18879975
SGTC_1332 1480-0653 17.5 µM 0.970808944406231 0.169845505167494 no 584 0.165821713849254 839 5749438
SGTC_2526 patulin 37.61 µM 0.970616736560685 0.169894104753944 no 585 0.165869584235536 866 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_483 fpl-64176 144 µM 0.970543146974356 0.169912714176819 no 586 0.165887914477839 782 3423
SGTC_1490 4089-0339 670 nM 0.968800066346608 0.170353888543065 no 587 0.166322476748161 805 742542
SGTC_1784 st039334 36.3 µM 0.968403210901538 0.170454435259335 no 588 0.166421518252239 816 3496984
SGTC_23 0213-0011 39.996 µM 0.967943496864444 0.170570955238034 no 589 0.166536294697518 827 627608
SGTC_1919 st067113 52.3 µM 0.967431791038213 0.170700713112947 no 590 0.166664111969297 811 1268243
SGTC_2166 5933061 31.504 µM 0.967373682953634 0.170715452099401 no 591 0.166678630593348 815 2877375
SGTC_1056 3448-1962 115 µM 0.967014719640099 0.170806520403686 no 592 0.16676833764211 791 715507
SGTC_3236 9132701 49.47 µM 0.966478078408831 0.170942723223752 no 593 0.166902505533837 828 24282524
SGTC_829 1635-0120 117 µM 0.966397056535963 0.170963293105411 no 594 0.166922768194872 880 285054
SGTC_3028 9087778 49.47 µM 0.961618277023978 0.172179333001443 no 595 0.168120693550672 878 17217395
SGTC_2110 5483698 200 µM 0.961458273009856 0.172220143956325 no 596 0.168160898191914 826 2848765 YHR062C RPP1
SGTC_2581 avocatin a 64 µM 0.960960844459644 0.172347058531447 no 597 0.168285927914125 837 6710728 A skin care supplement.
SGTC_2312 7706453 155.7 µM 0.957029994097706 0.1733520787414 no 598 0.169276058031833 813 976098
SGTC_981 1488-1094 54.9 µM 0.956795362047169 0.173412186062626 no 599 0.169335276832753 794 3449522
SGTC_2116 5511452 16.8835 µM 0.956362983066908 0.173522986332946 no 600 0.169444439822293 864 870744
SGTC_2226 7298446 200 µM 0.954800750120012 0.173923695303986 no 601 0.169839233999643 813 3283010
SGTC_1527 coumarin 137 µM 0.954737220528951 0.173940002931376 no 602 0.169855301126225 803 323 A hepatotoxic, DNA x-linker.
SGTC_1148 3909-7663 27.7 µM 0.953680784831752 0.174211325515207 no 603 0.170122624756672 877 4084526
SGTC_3089 9117425 49.47 µM 0.952912829561398 0.1744087268913 no 604 0.17031711958108 775 9401657
SGTC_1665 st014639 11.4 µM 0.952715937668251 0.174459360437487 no 605 0.170367007988233 895 981133 YIL048W NEO1
SGTC_2707 st078556 66.6 µM 0.951841290903663 0.174684401124094 no 606 0.170588738845439 849 17250899
SGTC_2053 5265679 138 µM 0.950630421787285 0.174996253584922 no 607 0.170896009906332 845 764595
SGTC_2005 4024620 188 µM 0.947207265838034 0.175879777357143 no 608 0.171766586835497 848 236743
SGTC_11 0438-0307 1.3 µM 0.945260812641804 0.176383418705636 no 609 0.172262869743639 843 4011476
SGTC_2433 5607874 27.82 µM 0.945205441641397 0.176397759189319 no 610 0.172277000936772 854 2252428
SGTC_1160 4092-0570 10.5 µM 0.944833035545975 0.176494227458688 no 611 0.172372061642837 854 4994975
SGTC_2712 st079126 47.7 µM 0.944812183782391 0.176499629896757 no 612 0.172377385271306 817 3152970
SGTC_1993 st073995 70.8 µM 0.944379438694331 0.176611772490152 no 613 0.172487892361784 875 3098394
SGTC_1545 lovastatin 49.4 µM 0.944038008413086 0.176700283338715 no 614 0.172575112906973 912 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_350 k064-0020 19.8 µM 0.941435693741039 0.177375816889368 no 615 0.173240814583243 917 2790705
SGTC_896 0964-0007 44.5 µM 0.94143293456111 0.177376534007734 no 616 0.173241521279514 889 6756758
SGTC_2467 5474540 200 µM 0.941060129347622 0.177473443928414 no 617 0.173337023071978 884 5413519
SGTC_1750 st081859 2.357 µM 0.940669630025294 0.177574989226899 no 618 0.17343709351208 994 5291695
SGTC_25 0118-0223 35.662 µM 0.940565441686178 0.177602088519426 no 619 0.173463799318395 855 5333628
SGTC_1865 st057639 52.2 µM 0.94056140677388 0.177603138048946 no 620 0.173464833609486 881 688818
SGTC_2205 7238770 200 µM 0.937476195661754 0.178406784270491 no 621 0.17425683142307 878 279867
SGTC_189 3970-0742 2.116 µM 0.936589300610119 0.178638228992056 no 622 0.174484928869491 884 2891807
SGTC_3278 9139605 49.47 µM 0.93643362480293 0.178678873751811 no 623 0.174524986143997 843 7958859
SGTC_2804 7954240 19.48 µM 0.935015246951128 0.179049460393546 no 624 0.174890220962881 895 828705
SGTC_2382 9035899 200 µM 0.933422509226582 0.179466178868044 no 625 0.175300931489331 877 6462679
SGTC_2743 auranofin 4.32 µM 0.93315330364665 0.179536673084626 no 626 0.175370410425758 851 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1459 k035-0031 35.7 µM 0.932263406410343 0.179769825550658 no 627 0.17560020712828 778 3877128 YMR208W ERG12
SGTC_957 1187-1561 14.1 µM 0.931802358157044 0.179890694644932 no 628 0.175719337866107 860 1538454
SGTC_1266 0828-0227 32.9 µM 0.931388373221786 0.179999269030468 no 629 0.175826351483108 845 3913820
SGTC_2499 avocadenofuran 51.48 µM 0.930640257627127 0.18019557904051 no 630 0.176019841349354 846 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1569 carminic acid 40.6 µM 0.929453075390293 0.180507378473427 no 631 0.176327166394972 903 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1296 1068-0102 11.9 µM 0.927611852094546 0.180991623056281 no 632 0.176804473754779 877 767053
SGTC_38 0929-0051 58.268 µM 0.927146676569566 0.181114093630672 no 633 0.176925192101959 927 1379719
SGTC_2502 avocadyne acetate 18.59 µM 0.926298020659619 0.181337659944892 no 634 0.177145562139534 974 3952079
SGTC_900 1112-0045 141 µM 0.925946993155299 0.18143018363971 no 635 0.177236763936225 774 56211 YIL048W NEO1
SGTC_1473 k844-0725 134 µM 0.92546073210655 0.18155840095618 no 636 0.177363150257965 973 54682906
SGTC_3090 9117696 49.47 µM 0.925339404147878 0.181590401551257 no 637 0.17739469402796 869 7923821
SGTC_124 0136-0217 7.121 µM 0.92512774988508 0.181646234415832 no 638 0.177449729998873 990 3976905
SGTC_2843 9000894 45.46 µM 0.922153265065705 0.182432017942732 no 639 0.178224318290934 746 2242070
SGTC_1103 duloxetine 36.1 µM 0.921692883383905 0.182553828615334 no 640 0.178344396860697 974 60835 A selective serotonin reuptake inhibitor.
SGTC_1282 0886-0010 32.4 µM 0.921546659679586 0.182592528026686 no 641 0.178382546169338 973 2836211 YNL267W PIK1
SGTC_329 k048-0121 21.3 µM 0.916906572710417 0.183823228332861 no 642 0.179595799738577 863 6832902
SGTC_2543 pimpinellin 60.67 µM 0.914700436329559 0.184410174644568 no 643 0.180174457620387 852 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2967 9089538 49.85 µM 0.914062517597576 0.184580111065308 no 644 0.180341998204848 908 728216
SGTC_1072 oxiconazole 14.9 nM 0.913336737642136 0.184773571394794 no 645 0.180532733167751 896 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_93 0109-0045 59.227 µM 0.911053967381887 0.185382876646974 no 646 0.18113346958253 1050 88733
SGTC_186 3455-3465 67.277 µM 0.908540058006092 0.186055317722793 no 647 0.181796479839073 839 755278
SGTC_2781 5567276 71.43 µM 0.908023505131103 0.18619367655794 no 648 0.181932901593485 860 2853274
SGTC_1662 st014054 52 µM 0.907151537167059 0.186427378048629 no 649 0.182163333774057 884 2838777
SGTC_649 1123-0311 367 µM 0.906352918678864 0.186641580033222 no 650 0.182374542106893 937 693629 YIL048W NEO1
SGTC_607 4491-0986 66.8 µM 0.904521458192727 0.18713338153532 no 651 0.182859480664665 940 698981 YDR232W HEM1
SGTC_1200 1643-0193 18.4 µM 0.902424802681538 0.18769737874744 no 652 0.183415625260486 956 5403974
SGTC_580 1123-0028 41 µM 0.901764194546758 0.187875298669913 no 653 0.183591071917541 1037 1677248 YPR107C YTH1
SGTC_2837 9008476 45.46 µM 0.899203862103746 0.188565850025733 no 654 0.184272041788008 905 2992805
SGTC_274 sirtinol 40.1 µM 0.898757403677395 0.188686425085453 no 655 0.184390946765059 901 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3032 9089427 49.47 µM 0.897948601235915 0.188904979422145 no 656 0.18460647611381 884 17173707
SGTC_1615 st002656 86.5 µM 0.897930992679254 0.188909739334855 no 657 0.184611170176652 891 1584458
SGTC_1755 st041960 45.185 µM 0.89725836984602 0.189091616824406 no 658 0.184790532534236 909 2257073
SGTC_307 1501-1223 22.3 µM 0.896742497677898 0.189231181918549 no 659 0.184928168954708 893 2830329
SGTC_2553 4-methylesculetin 85.09 µM 0.896029708405399 0.189424125689093 no 660 0.1851184483067 949 5319502
SGTC_604 1000-0114 314 µM 0.895810521871995 0.189483481267277 no 661 0.185176984670119 971 1572745
SGTC_1075 aripiprazole 15.2 µM 0.895437033913731 0.189584647939158 no 662 0.185276755539793 965 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2000 st075254 36.4 µM 0.894767838484879 0.18976599597658 no 663 0.18545560302698 893 17234175
SGTC_2664 lyso-paf C-16 73.48 µM 0.893976761878746 0.189980510641052 no 664 0.185667162333061 954 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_273 hydroxyurea 18.1 mM 0.891125123887842 0.190755019974089 no 665 0.186431023952896 988 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3301 9125354 19.7965 µM 0.889509292105466 0.191194741183135 no 666 0.186864715784914 846 41905162
SGTC_139 0099-0334 718.624 µM 0.889182954464624 0.19128362380451 no 667 0.186952381050008 1050 97690
SGTC_1554 st069299 38.7 µM 0.885918563039812 0.192174119673891 no 668 0.187830706176475 916 24207999
SGTC_1363 1636-0063 10.4 µM 0.884530882697748 0.192553433018798 no 669 0.188204849468533 959 6072185
SGTC_3120 9124077 49.47 µM 0.882495468374459 0.193110627448207 no 670 0.188754464636692 964 18774327 YGL155W CDC43
SGTC_3077 9117319 49.47 µM 0.882328833093259 0.193156287388316 no 671 0.18879950429259 911 17154678
SGTC_3014 9081533 49.47 µM 0.881044854847072 0.193508332851547 no 672 0.18914677136602 939 21367265
SGTC_785 1270-0111 65.3 µM 0.880580014960509 0.193635880645883 no 673 0.189272589717061 975 6741994
SGTC_1426 4048-4480 71.7 µM 0.880240877764675 0.193728969114981 no 674 0.189364416583879 951 14224343
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.876315396540356 0.194808443993175 no 675 0.19042929861651 915 6710655
SGTC_1031 k035-0009 16 µM 0.876204437247007 0.194839009953904 no 676 0.190459452362277 1001 5180959
SGTC_1931 st074438 57.1 µM 0.875092724207256 0.195145414572352 no 677 0.190761727791807 940 2787313
SGTC_2221 6807166 181.081 µM 0.874528461250876 0.195301045803895 no 678 0.19091526378988 898 674925
SGTC_1695 st026914 34.495 µM 0.872552583839632 0.195846613187361 no 679 0.19145349743125 937 3289191
SGTC_1249 0481-0015 10.2 µM 0.872344219810388 0.195904199266791 no 680 0.191510310424276 913 4227577
SGTC_3073 9114972 49.47 µM 0.870627931193182 0.19637892491473 no 681 0.19197867027166 874 41905075
SGTC_2653 dihydrofissinolide 100 µM 0.870292402292161 0.196471813667344 no 682 0.192070314968602 955 6857746
SGTC_2384 9036245 200 µM 0.869372398524186 0.19672664662536 no 683 0.192321737526558 969 6462766
SGTC_540 1187-0821 17.3 µM 0.868217244630431 0.197046897427912 no 684 0.192637707784143 929 847520
SGTC_148 3253-0744 288.01 µM 0.867122487428616 0.197350695090475 no 685 0.192937450304424 953 6893655
SGTC_3066 9117245 49.47 µM 0.866844033817518 0.197428011780402 no 686 0.19301373581026 999 17176980
SGTC_673 1082-0474 110 µM 0.865919228161306 0.197684928916052 no 687 0.193267228885664 1042 3098046
SGTC_934 2950-0684 338 µM 0.865224877266551 0.197877956932911 no 688 0.193457686832238 992 1121253
SGTC_2951 9072950 58.06 µM 0.86429907900046 0.198135503853924 no 689 0.193711807995525 1047 16488155
SGTC_1138 3761-0006 1.03 µM 0.86367003411875 0.198310612657273 no 690 0.193884589776019 965 12061087
SGTC_1091 telmisartan 47.6 µM 0.863499610314713 0.198358070034731 no 691 0.193931416796339 970 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_231 b-estradiol 524 µM 0.861351560488167 0.198956818065386 no 692 0.19452222304336 887 450 A steroid.
SGTC_2423 st077119 87.2 µM 0.860892978473911 0.199084784291899 no 693 0.194648494604373 952 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_448 monastrol 171 µM 0.858631087386911 0.199716684795258 no 694 0.195272040605392 975 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1687 st020778 55.3625 µM 0.856836287286374 0.200218952494796 no 695 0.195767684057782 1031 4259299
SGTC_3167 9103034 49.47 µM 0.853151247087726 0.20125257272694 no 696 0.196787717667993 938 5127859
SGTC_1945 st075991 56.6 µM 0.852467887045035 0.201444600036461 no 697 0.196977227565399 870 1084980
SGTC_879 0831-1030 162 µM 0.852099905097878 0.2015480501214 no 698 0.197079322327871 970 1549252
SGTC_2608 thymoquinone 42.66 µM 0.851713495899189 0.20165671487919 no 699 0.197186564102357 921 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2397 5161689 200 µM 0.847896739042621 0.202731935081761 no 700 0.198247740392898 974 2259942
SGTC_3171 9103192 49.47 µM 0.84787126741531 0.202739122192633 no 701 0.198254833851272 1032 13018434
SGTC_728 3030-5151 22.5 µM 0.846118914087287 0.20323393415577 no 702 0.19874320516786 939 3125388
SGTC_1509 1326-1131 80 µM 0.842274699755306 0.204321946742394 no 703 0.199817104663851 956 768313
SGTC_245 methotrexate 289.6 µM 0.840913844368514 0.204707933762659 no 704 0.200198100987855 985 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1271 0832-2808 169 µM 0.840352112297918 0.204867387358958 no 705 0.20035549535592 1019 3663794
SGTC_368 fentichlor 4.58 µM 0.839513513315445 0.20510556994022 no 706 0.20059060465642 911 7329 A pesticide.
SGTC_3321 9137793 26.8275 µM 0.837917280087246 0.205559393642987 no 707 0.201038581515512 1007 4904192
SGTC_2165 5727197 32.143 µM 0.836888651001464 0.205852157899096 no 708 0.20132758010293 942 1361712
SGTC_2763 lisinopril 49.32 µM 0.836771556188993 0.205885500627676 no 709 0.201360494268354 960 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2772 vinpocetine 57.06 µM 0.836155155766163 0.206061073363848 no 710 0.20153381135342 949 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1966 st070145 16.1 µM 0.832438991914396 0.207121448571811 no 711 0.202580600372632 992 3748532
SGTC_1191 1487-1166 10.6 µM 0.830912241173688 0.207558027491744 no 712 0.203011603923408 1076 3955771
SGTC_423 5-fluorouracil 457 µM 0.830003246808849 0.207818215210485 no 713 0.203268473974359 936 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_709 3807-1509 243 µM 0.829512082439508 0.207958884698582 no 714 0.203407351357602 1005 1886677 YPL242C IQG1
SGTC_1117 retinoic acid 1.10837 µM 0.828835527903171 0.208152741957463 no 715 0.203598740724099 1036 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3086 9117350 49.47 µM 0.827843042441164 0.208437317704214 no 716 0.203879697499368 972 2679265
SGTC_3233 9132340 49.47 µM 0.826618477462821 0.208788753713461 no 717 0.204226670518463 1006 17682950
SGTC_1502 4534-4282 27.7 µM 0.826285627634783 0.208884338088255 no 718 0.204321042232534 969 3278949
SGTC_539 4859-0462 2.54 µM 0.825816629055787 0.209019063999885 no 719 0.204454059768532 1037 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1203 3992-3522 103 µM 0.825813455057948 0.209019975946153 no 720 0.204454960154429 1050 5322312
SGTC_3273 9137859 49.47 µM 0.825773130725439 0.20903156205109 no 721 0.20446639939107 1039 2377234
SGTC_2851 9015922 71.43 µM 0.825714404915904 0.209048435998619 no 722 0.204483059453722 983 2996893
SGTC_2739 tacrine 100.86 µM 0.825531169749498 0.209101090928368 no 723 0.204535047060711 995 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_244 nsc-207895 1.295 µM 0.825480908156701 0.209115535594009 no 724 0.204549308688788 885 42640
SGTC_849 0386-0493 241 µM 0.8251664390929 0.209205924110764 no 725 0.20463855209941 978 726119
SGTC_1181 1222-0449 220 µM 0.825102351492608 0.209224347767927 no 726 0.204656742408481 1008 658318
SGTC_2694 st077685 81.9 µM 0.822361144857241 0.210013273060004 no 727 0.205435693180442 995 2838096
SGTC_1656 st012921 11 µM 0.821650635298647 0.210218044161072 no 728 0.205637880990679 944 6732821
SGTC_642 0335-0876 158 µM 0.820746054738266 0.210478916744552 no 729 0.205895465913175 1016 6812350
SGTC_3235 9132602 49.47 µM 0.819039676970092 0.210971537119364 no 730 0.206381888326621 1045 4912240
SGTC_992 3909-8734 162 µM 0.81900433318548 0.210981747784692 no 731 0.206391970667815 1005 4288319
SGTC_2088 5278280 127.392 µM 0.818435492128883 0.211146123336992 no 732 0.206554281200956 1032 791502
SGTC_991 3996-0057 64.7 µM 0.817590388959074 0.211390467685864 no 733 0.206795558667779 968 715343
SGTC_2601 securinine 100 µM 0.81719903016042 0.211503677183513 no 734 0.206907348341421 974 442872 A GABA receptor antagonist.
SGTC_295 k015-0027 31 µM 0.815171954639016 0.212090623092032 no 735 0.207486944413874 993 3887424
SGTC_2815 7968870 71.43 µM 0.813430774333449 0.212595546731058 no 736 0.207985560566691 1036 2977326 YHR190W ERG9
SGTC_3002 9075603 71.4286 µM 0.811278773544583 0.213220572940958 no 737 0.208602798481938 1050 20105405
SGTC_355 1311-2252 105 µM 0.807464966540753 0.214330881934529 no 738 0.209699325303463 992 5338538
SGTC_1253 0550-0034 176 µM 0.807046600261623 0.214452884746603 no 739 0.209819817841864 978 5969915
SGTC_1512 0259-0544 12.2 µM 0.806422309684769 0.214635013696418 no 740 0.209999693738275 1058 18476
SGTC_2792 7535235 81.82 µM 0.804363750847593 0.215236209024912 no 741 0.210593464820432 974 1281891
SGTC_1916 st067606 49.2 µM 0.804136868687374 0.215302528953501 no 742 0.210658966969373 1057 19590279
SGTC_2117 5521686 200 µM 0.803875392692958 0.215378975712449 no 743 0.210734471375695 1010 803312
SGTC_1583 clindamycin 39.6 µM 0.80375116835102 0.215415300236343 no 744 0.210770348242595 924 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_670 4204-0025 119 µM 0.802803710076534 0.215692464051894 no 745 0.211044098721309 1062 719039
SGTC_1104 tacrolimus 29.8 µM 0.802680086595446 0.215728643372269 no 746 0.211079832795486 1061 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1094 duloxetine 25.4 µM 0.800611286923418 0.216334614631169 no 747 0.21167835722915 1023 60834 A selective serotonin reuptake inhibitor.
SGTC_1255 0566-0045 221 µM 0.799302584868501 0.216718454257298 no 748 0.212057490210841 1026 2788469
SGTC_147 4466-0538 29.23 µM 0.7990092048102 0.216804556038489 no 749 0.212142537316665 1159 6742687 YHR072W ERG7
SGTC_3093 9117344 49.47 µM 0.797206291623849 0.217334112769379 no 750 0.212665616315071 982 24824913
SGTC_1614 st002383 48.6 µM 0.79569029731689 0.217779972400364 no 751 0.213106033885152 1069 1947235
SGTC_2089 5281248 129.67 µM 0.795360624375611 0.217877000251768 no 752 0.21320187887158 1019 2737878
SGTC_1611 st001856 99.4 µM 0.794499455528386 0.21813057316426 no 753 0.21345236290067 1018 647478
SGTC_2300 7976697 71.57 µM 0.792478437064035 0.218726333677412 no 754 0.214040879953717 940 2236109
SGTC_2926 9010726 65.15 µM 0.790766398183275 0.21923174431517 no 755 0.214540160753415 1047 2994293
SGTC_376 3970-0862 59.1 µM 0.789751961385526 0.219531532445286 no 756 0.214836319472426 1073 3135186
SGTC_1638 st008370 60.6 µM 0.78915986165942 0.219706619561998 no 757 0.21500928913532 1067 24207134
SGTC_2910 7948405 25.97 µM 0.787912317350976 0.220075787524526 no 758 0.215373997927254 1036 2971328
SGTC_2419 paclitaxel 166.5 µM 0.787810579574544 0.220105909015327 no 759 0.2154037559069 1054 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1155 4088-0394 48.2 µM 0.786801234022223 0.220404873908724 no 760 0.215699115503946 1034 2326248
SGTC_2860 9025725 38.96 µM 0.786288101135365 0.22055695141129 no 761 0.215849360918759 999 40546248
SGTC_1422 4031-0024 15.5 µM 0.786261623583804 0.220564800210043 no 762 0.215857115196443 1049 782427
SGTC_2891 9063876 19.48 µM 0.78481507480542 0.22099384697722 no 763 0.216281000127715 1016 6472478
SGTC_941 3237-0776 460 µM 0.783889840726324 0.221268521953522 no 764 0.2165523757247 1056 760008
SGTC_10 0279-0212 42.575 µM 0.783603042357915 0.221353703641601 no 765 0.216636535042496 1128 39851 YBR002C RER2
SGTC_1021 4476-0760 85.3 µM 0.783173954211842 0.221481181679127 no 766 0.216762483790299 1064 746768
SGTC_2907 7721985 69.9 µM 0.782346460525482 0.221727140716463 no 767 0.217005494657194 1067 3267881
SGTC_917 harmaline 728.087 nM 0.781710736651927 0.221916205246441 no 768 0.217192295194794 1032 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1430 4049-0248 69.1 µM 0.780310515252221 0.222332956177054 no 769 0.217604062452709 1132 22774488
SGTC_2641 levomentholum 100 µM 0.779637229307358 0.222533506584237 no 770 0.217802217929527 1044 16666
SGTC_2311 7694451 200 µM 0.778159466497599 0.222974046450616 no 771 0.218237504553988 1011 2163142
SGTC_21 0849-0113 22.993 µM 0.77675078942457 0.223394453041483 no 772 0.218652907703362 1066 1560156
SGTC_611 3453-1652 23.7 µM 0.775288732853426 0.223831266826416 no 773 0.219084532821942 1099 1560575
SGTC_3108 9121785 49.47 µM 0.773890542568128 0.224249453230023 no 774 0.219497761403805 1067 17140271
SGTC_1944 st076371 56.9 µM 0.773774170292519 0.224284279139228 no 775 0.219532174855773 1042 24208455
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.773291459610494 0.224428769336284 no 776 0.219674954490696 1048 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1996 st072960 66.8 µM 0.772561166104697 0.224647469097777 no 777 0.219891067277248 1098 1719405
SGTC_92 0063-0024 660.874 µM 0.77078685620686 0.225179322006618 no 778 0.220416639627828 1165 3594437
SGTC_1205 4161-2785 76 µM 0.76992821401002 0.225436957599655 no 779 0.220671238279194 979 3498106
SGTC_82 0054-0107 293.755 µM 0.7696307852458 0.225526239999085 no 780 0.220759469067387 1081 3104697
SGTC_1197 1601-0112 267 µM 0.768732547813809 0.225795995063353 no 781 0.221026049409426 1104 7350313
SGTC_3169 9102970 49.47 µM 0.7686958987115 0.22580700524838 no 782 0.221036930099036 1127 17027839
SGTC_1717 st033143 58.0435 µM 0.768159686821918 0.225968129644865 no 783 0.221196160182952 1092 674616
SGTC_1740 st038286 13.222 µM 0.766582179709325 0.226442525833129 no 784 0.221664987005864 1073 716786
SGTC_1907 st060210 83.7 µM 0.766371968909876 0.226505783961033 no 785 0.221727503394932 1130 688793
SGTC_2062 5245942 200 µM 0.765397334854416 0.226799208103633 no 786 0.222017489750831 1183 1376160
SGTC_395 anisomycin 6.25 µM 0.764344664699328 0.22711636661744 no 787 0.22233093755255 1009 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_344 k064-0035 6.43 µM 0.764049541653677 0.227205328959822 no 788 0.222418860007506 1055 5088750
SGTC_1449 4112-4002 201 µM 0.763576548911556 0.227347949569842 no 789 0.222559814391866 1072 2059539
SGTC_116 0155-0182 31.788 µM 0.762828255657881 0.227573684009998 no 790 0.222782913801477 1101 771486
SGTC_2972 9093619 59.92 µM 0.762018797439245 0.227818011863509 no 791 0.223024392628494 1070 25236256
SGTC_2520 obtusaquinone 4.71 µM 0.761719599179502 0.227908359581995 no 792 0.223113687634031 1134 5967872
SGTC_1064 honokiol 6.76 µM 0.761313121460271 0.228031134345662 no 793 0.22323503254526 1083 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1470 k295-0292 231 µM 0.760443141170212 0.22829403294216 no 794 0.223494872074293 1108 5045612
SGTC_1264 0783-0040 158 µM 0.758860211818102 0.228772813704249 no 795 0.223968091185101 1034 2855798
SGTC_3015 9080845 49.47 µM 0.758698519373323 0.228821751723827 no 796 0.224016461410431 1149 5296973
SGTC_412 gemfibrozil 100 µM 0.758580204413285 0.22885756478717 no 797 0.224051859039673 1082 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1962 st076595 64.5 µM 0.75751776617525 0.229179297911856 no 798 0.224369863078984 1122 279619
SGTC_153 4077-0274 519.67 µM 0.757188737645932 0.229278987475556 no 799 0.224468398289655 1087 3121976
SGTC_2445 5742597 35.57 µM 0.756850249347106 0.229381568540805 no 800 0.22456979206803 1049 1774255
SGTC_1976 st070609 63.5 µM 0.756236348098077 0.22956768090159 no 801 0.224753751758793 1080 682556
SGTC_2834 9001755 58.44 µM 0.755495824741891 0.229792292978183 no 802 0.224975768293778 1008 2989575
SGTC_1725 st036284 20.55 µM 0.754769188589487 0.230012812416367 no 803 0.225193742073741 1135 707914
SGTC_735 3076-0345 636 µM 0.7527786324346 0.230617512285145 no 804 0.225791474493318 1138 2888990
SGTC_2881 9058953 51.95 µM 0.75207780285588 0.230830624605891 no 805 0.226002135890622 1127 17122249
SGTC_1923 st058458 19.1 µM 0.751074384490846 0.231135941248471 no 806 0.22630394536868 1160 3534982
SGTC_3038 9091290 49.47 µM 0.749742095510507 0.231541673512907 no 807 0.226705024583476 1110 25236843
SGTC_2435 5706476 10.6 µM 0.749587759843154 0.231588700193378 no 808 0.226751512508548 1150 5725375
SGTC_1187 1391-0724 117 µM 0.74803898523681 0.232060912517651 no 809 0.227218321429052 1125 6997986
SGTC_936 3005-4620 401 µM 0.747767056447438 0.232143877299506 no 810 0.227300338075275 1135 777207
SGTC_194 1486-1323 56.904 µM 0.747293821192926 0.232288299528561 no 811 0.227443110684003 1125 5178754
SGTC_1476 4112-3294 3.34 µM 0.744985753301109 0.232993393111208 no 812 0.228140166243841 1127 704369
SGTC_1372 2752-0194 270 µM 0.744945128243329 0.233005814329712 no 813 0.228152446094677 1068 823334
SGTC_2426 5582046 32.21 µM 0.74477814099662 0.233056874982918 no 814 0.228202925704123 1109 2251934
SGTC_561 1550-0330 72.9 µM 0.743304023704988 0.233507893744345 no 815 0.228648818031103 1092 6812934
SGTC_3085 9117376 49.47 µM 0.740513156182675 0.234363107813701 no 816 0.229494340640936 1112 16480349
SGTC_390 dec-rvkr-cmk 16.7 µM 0.739274727345139 0.234743157879051 no 817 0.229870096155258 1150 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_744 1594-0068 283 µM 0.738947934139914 0.23484350123645 no 818 0.229969306893426 1162 668392
SGTC_3168 9103419 49.47 µM 0.737799699326375 0.235196259943864 no 819 0.230318088024041 1086 16649256
SGTC_16 erodoxin 22.806 µM 0.736242307537006 0.235675186373518 no 820 0.230791624626709 1184 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2722 naftopidil 47.16 µM 0.735645915072327 0.23585873027665 no 821 0.230973106094136 1135 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1005 4092-0690 4.4 µM 0.734280881392719 0.236279125253504 no 822 0.231388783799698 1106 1529343
SGTC_505 gw-5074 63.9 µM 0.732865405661656 0.236715490486676 no 823 0.231820262267752 1116 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1367 1812-0510 76.9 µM 0.732079591810824 0.236957933714153 no 824 0.23205999469323 1127 1142582 YDR527W RBA50
SGTC_2482 5981709 142.65 µM 0.731750400434999 0.237059538038287 no 825 0.232160463867324 1099 877755
SGTC_691 1548-0686 185 µM 0.731357249645607 0.237180914683945 no 826 0.232280485162956 1130 46495133
SGTC_280 3448-3607 3.04 µM 0.72949133681222 0.237757439424345 no 827 0.23285058257371 1133 626179
SGTC_2928 9011484 9.79 µM 0.729036940887572 0.237897953758949 no 828 0.232989533006289 1122 2994751
SGTC_699 0375-0592 111 µM 0.728749601399917 0.237986832182093 no 829 0.233077422754288 1179 762578
SGTC_594 1487-1584 10.8 µM 0.724691403018568 0.239244035908164 no 830 0.234320685195433 1146 5013332
SGTC_2326 6164455 177.58 µM 0.723460204312927 0.23962616954048 no 831 0.234698597467138 1123 2888790
SGTC_2692 st077426 47.7 µM 0.722978206758346 0.239775860353831 no 832 0.234846636724806 1159 25238571
SGTC_2747 doxorubicin 7.63 µM 0.722524504529129 0.239916810275528 no 833 0.234986032585162 1031 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1427 4048-4900 550 nM 0.721358791553068 0.240279164952645 no 834 0.235344396769324 1143 24132586
SGTC_1511 0906-3109 28.5 µM 0.721050265233647 0.240375118334602 no 835 0.235439294579746 1217 2882180
SGTC_1172 0370-0043 85 µM 0.721036494157896 0.240379401701466 no 836 0.235443530836853 1177 376585
SGTC_3208 9114115 49.47 µM 0.719894689813505 0.240734694074123 no 837 0.235794918881967 1122 650895
SGTC_597 k018-0003 82.8 µM 0.719624061455055 0.24081894669293 no 838 0.235878246595938 1245 6786234
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.717196836522921 0.24157531245706 no 839 0.236626325487129 1170 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1698 5-fluorocytosine 1.055 µM 0.717137850028104 0.241593709722094 no 840 0.236644521554348 1177 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_619 1652-1634 108 µM 0.716410159142214 0.241820731394842 no 841 0.236869061881041 1122 5400454
SGTC_1399 3562-5772 25 µM 0.714176352990762 0.24251834652539 no 842 0.237559068608913 1113 23847490
SGTC_421 streptovitacin 30 mM 0.713960484169753 0.242585819823388 no 843 0.23762580734436 1162 91467 include heat shock
SGTC_2767 sibutramine 71.45 µM 0.712697285122019 0.242980856866867 no 844 0.238016548406092 1198 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2939 9044578 71.43 µM 0.712637983331493 0.242999410713679 no 845 0.238034900678214 1159 2653634
SGTC_2090 5301565 104.445 µM 0.712432969138651 0.243063559738603 no 846 0.238098352904044 1179 2056344
SGTC_1603 st002045 67.8 µM 0.712401028061548 0.243073554939257 no 847 0.238108239553841 1180 5887985
SGTC_3341 9147222 25.867 µM 0.712353396367468 0.24308846055832 no 848 0.238122983302927 1134 1939759
SGTC_3126 9127922 49.47 µM 0.710342472877385 0.243718199398623 no 849 0.238745893763124 1210 45595682
SGTC_184 1494-0393 24.714 µM 0.7087145130137 0.24422865412694 no 850 0.239250828387045 1183 3090647
SGTC_2003 4023581 200 µM 0.708155308532955 0.244404128315998 no 851 0.239424408051056 1179 16641307
SGTC_74 000s-0487 160.283 µM 0.707870637336265 0.244493482099468 no 852 0.23951279772026 1158 677548
SGTC_119 0121-0043 24.815 µM 0.707618549186819 0.244572623270564 no 853 0.239591085309407 1265 1092378
SGTC_122 0236-0016 402.397 µM 0.706827417517067 0.244821082659222 no 854 0.239836866997084 1245 6808838
SGTC_622 1348-1566 26.3 µM 0.706189142538882 0.245021635514967 no 855 0.240035260743486 1206 7340407
SGTC_587 k089-0003 57 µM 0.705206670240417 0.24533051150898 no 856 0.240340815447807 1126 9659696
SGTC_635 k038-0028 24.7 µM 0.705153352711338 0.245347279803597 no 857 0.240357403574754 1198 4035102
SGTC_3259 9138485 49.47 µM 0.704663503879138 0.245501365458023 no 858 0.240509834318484 1296 17646153
SGTC_823 0417-1665 178 µM 0.703611513339288 0.245832452681798 no 859 0.240837369681772 1201 3429856
SGTC_2447 5741742 33.78 µM 0.703347498552043 0.245915582217543 no 860 0.240919608289448 1203 1776504
SGTC_821 1114-0266 29.2 µM 0.703145313525999 0.245979253802296 no 861 0.240982597721102 1174 3123235
SGTC_1616 st002734 56.1 µM 0.702029262455527 0.246330876831725 no 862 0.241330457302237 1160 4026101
SGTC_2132 5317594 122.667 µM 0.701451985049495 0.246512859510908 no 863 0.241510494670756 1162 794577
SGTC_76 0433-0009 400.328 µM 0.700306199096336 0.246874273810374 no 864 0.241868050598305 1121 2841569
SGTC_3351 9150312 21.596 µM 0.699609484862906 0.247094176375166 no 865 0.242085608775869 1174 4904905
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.699532612457019 0.247118445880388 no 866 0.242109619693341 1171 6708760
SGTC_2130 NSC 7 2.4545 µM 0.698970151945253 0.247296059939111 no 867 0.242285342210286 1183 21448
SGTC_1491 4138-0063 26.5 µM 0.697660792877558 0.247709794218946 no 868 0.242694676524309 1164 23883227
SGTC_1231 0242-0792 125 µM 0.695309273539804 0.248453759747066 no 869 0.243430751934038 1200 3707635
SGTC_559 1550-0661 158 µM 0.695047913896468 0.248536521269526 no 870 0.243512637458552 1202 5830875
SGTC_930 2810-3379 265 µM 0.69443736501679 0.248729913444202 no 871 0.243703984001786 1242 1015764
SGTC_114 0364-0001 490.298 µM 0.694331426079735 0.248763477900859 no 872 0.243737193618192 1193 4003655
SGTC_473 2-arachidonoylglycerol 10 µM 0.6941526521439 0.24882012401694 no 873 0.243793241005849 1155 5282280 An endocannabinoid.
SGTC_2452 5863136 48.41 µM 0.694077764370865 0.248843854916395 no 874 0.243816721126627 1175 2184096
SGTC_2710 st078562 53.7235 µM 0.69356595173975 0.24900607351062 no 875 0.243977226220403 1176 17250908
SGTC_2339 9000433 200 µM 0.693460635652511 0.249039460337342 no 876 0.244010260549785 1167 2988954
SGTC_2322 7413319 38.22 µM 0.693230890284479 0.249112301432698 no 877 0.244082332785671 1218 1840400
SGTC_791 1348-1292 225 µM 0.693065259615036 0.249164821901304 no 878 0.244134299051087 1210 5437054
SGTC_1014 4130-3005 69.3 µM 0.692589060411091 0.24931585454656 no 879 0.244283738754142 1230 743608
SGTC_2821 7996764 71.43 µM 0.691970300775032 0.249512174734914 no 880 0.244477990070841 1275 2987135
SGTC_1644 st010134 20.9 µM 0.691548975798901 0.249645899806099 no 881 0.244610307025371 1185 3818134
SGTC_2838 9002687 71.43 µM 0.691044084313033 0.249806198326304 no 882 0.244768918799087 1198 6457060
SGTC_1477 0139-0234 16 µM 0.690477279680657 0.249986218803848 no 883 0.244947046547492 1196 620880
SGTC_2591 skatole 100 µM 0.690392534989848 0.250013140129546 no 884 0.244973684963506 1211 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2726 cimetidine 79.27 µM 0.688899498859496 0.250487693560609 no 885 0.245443257413974 1208 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2841 9004761 38.96 µM 0.688720806141962 0.250544522036405 no 886 0.245499490169287 1125 2991039
SGTC_1086 cerivastatin 2.18 µM 0.688250618310805 0.25069408542399 no 887 0.245647486492398 1172 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1186 1319-0216 26 µM 0.686458310315413 0.251264639161598 no 888 0.246212072519711 1260 4565136
SGTC_2139 5578692 56.4705 µM 0.685964120228435 0.251422077661317 no 889 0.246367867167547 1163 650991 YMR113W FOL3
SGTC_924 2046-0044 21.3 µM 0.684841304956214 0.251779976548257 no 890 0.246722033775386 1230 3623589
SGTC_1997 st073024 93.8 µM 0.682101354818886 0.252654467220867 no 891 0.247587431996206 1210 686268
SGTC_2711 st079103 59.1 µM 0.680979083015583 0.253013116107589 no 892 0.247942362926989 1206 54693780
SGTC_2754 granisetron 64.02 µM 0.679719352592685 0.253416012066087 no 893 0.248341089909838 1222 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_723 4182-0001 115 µM 0.67829300777355 0.253872602528323 no 894 0.248792965593175 1187 744821 YLR208W SEC13
SGTC_137 0438-0332 85.389 µM 0.677510356968298 0.254123321991405 no 895 0.249041100538793 1255 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_871 0574-0004 149 µM 0.676908523664688 0.254316205489984 no 896 0.249231997850468 1193 9551173
SGTC_912 3474-0017 2.18 µM 0.676783891821175 0.254356158741957 no 897 0.249271539922175 1255 3360550
SGTC_1552 6-methylflavone 10.6 µM 0.676137182683992 0.25456352721943 no 898 0.249476775538158 1200 689013
SGTC_2472 5377652 49.4 µM 0.674763181271403 0.255004397094181 no 899 0.249913118023016 1223 1610903
SGTC_1803 st050068 52.4 µM 0.673267053041873 0.255484907188231 no 900 0.250388704673963 1319 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1277 0873-0036 22 µM 0.673136274076361 0.255526931816945 no 901 0.250430299252638 1255 5965735
SGTC_2592 piperlongumine 83.33 µM 0.672182862323035 0.25583341108778 no 902 0.250733644888926 1203 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_172 1112-0046 2.638 µM 0.669845325830468 0.256585635678588 no 903 0.251478198051937 1174 2802135 YIL048W NEO1
SGTC_251 melphalan 456.522 µM 0.668620633979924 0.256980203684219 no 904 0.251868753355757 1293 460612 A DNA alkylator.
SGTC_1913 st060213 96.1 µM 0.668247349335835 0.257100530287788 no 905 0.251987857790661 1261 688959
SGTC_1323 1348-1351 11.2 µM 0.666284335026554 0.257733780850635 no 906 0.25261468819052 1201 6989654
SGTC_482 fipronil 114 µM 0.664054858174507 0.258453970533177 no 907 0.253327600408673 1271 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_752 1896-0090 130 µM 0.66376105688181 0.258548955079543 no 908 0.253421627057514 1249 772567
SGTC_2942 9052777 62.25 µM 0.661841809953727 0.259169882859473 no 909 0.254036303902128 1341 6469503
SGTC_250 brefeldin a 552.239 µM 0.661000746931882 0.259442231992983 no 910 0.25430591727768 1159 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_987 1497-1013 404 µM 0.660864697440682 0.259486300795565 no 911 0.254349543751341 1237 1676435
SGTC_3125 9127534 49.47 µM 0.660488890935766 0.259608051161016 no 912 0.25447007257763 1147 1639235
SGTC_2865 9030313 51.95 µM 0.660186814493142 0.259705936509295 no 913 0.254566976358016 1199 42562754
SGTC_911 3456-4043 236 µM 0.65991954989877 0.259792557248875 no 914 0.254652728882126 1315 914281
SGTC_1220 1838-0075 193 µM 0.659569244205333 0.259906114267961 no 915 0.254765148258727 1188 5529645
SGTC_2614 arthonioic acid 13.39 µM 0.658914848408319 0.260118315375071 no 916 0.25497522518548 1206 6710684
SGTC_1379 2144-0755 36.5 µM 0.656041645254726 0.261051065558443 no 917 0.255898664621692 1279 5392327
SGTC_2099 5377090 177.372 µM 0.654685336857924 0.261491971124789 no 918 0.256335183945536 1253 2243829
SGTC_714 4296-0578 26.1 µM 0.652654115100469 0.262152990265691 no 919 0.25698964498406 1252 1589775
SGTC_1065 prochlorperazine maleate 2.48 µM 0.652276640922932 0.262275925713768 no 920 0.257111363129801 1296 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1113 artemisinin 1.17947 µM 0.652272544047592 0.26227726014239 no 921 0.257112684349026 1276 2240 An anti-malaria and mitochondrial poison.
SGTC_2094 5332512 191.667 µM 0.646874007511673 0.264038680634633 no 922 0.258856744734367 1319 755774
SGTC_1789 tunicamycin 25 nM 0.646439301412358 0.264180777194378 no 923 0.258997447443248 1266 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1711 st032263 62.8 µM 0.645560234215897 0.264468245309782 no 924 0.259282098748052 1281 3958979
SGTC_26 0302-0163 425.158 µM 0.645016657142728 0.264646082756971 no 925 0.259458195641765 1279 3100915
SGTC_3198 9112019 49.47 µM 0.644531996791182 0.26480469620235 no 926 0.259615257987677 1315 45595555
SGTC_842 0271-0008 11.1 µM 0.644083891811842 0.264951389259448 no 927 0.259760517608843 1330 1221709
SGTC_3186 9110464 49.47 µM 0.642976939790372 0.265313941477261 no 928 0.260119531588968 1294 17018021
SGTC_2582 agaric acid 100 µM 0.642373657978454 0.265511636097544 no 929 0.260315299557775 1199 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_736 0958-0254 92.6 µM 0.64227973068292 0.265542422665139 no 930 0.260345786263377 1328 6812352
SGTC_2931 9014674 55.67 µM 0.642140147249767 0.265588177298454 no 931 0.260391095330653 1274 2996810
SGTC_420 mitomycin C 81.9 mM 0.641685238743462 0.265737321393126 no 932 0.260538787743965 1281 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2868 9035608 32.47 µM 0.641361781795933 0.265843394240433 no 933 0.2606438287995 1266 6462614
SGTC_311 1315-0136 58 µM 0.640072243421216 0.266266492174856 no 934 0.2610628166257 1335 6759207
SGTC_1420 4'-methoxyflavone 42 µM 0.639918976306632 0.266316801814439 no 935 0.261112638120929 1286 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3095 9117207 49.47 µM 0.639130717741896 0.266575622163229 no 936 0.261368949133612 1249 17015229
SGTC_2173 5763948 167 µM 0.638199088403099 0.266881681430207 no 937 0.261672045272912 1290 2867177
SGTC_346 4513-0042 7.16 µM 0.63773362520926 0.267034662074717 no 938 0.261823546534285 1295 2827372
SGTC_1668 st014914 51.6 µM 0.637329735705374 0.267167441583461 no 939 0.261955042934478 1286 2839556
SGTC_3324 9138759 60.749 µM 0.636615054997935 0.267402475974147 no 940 0.262187808180499 1292 45595710
SGTC_2057 5236571 38.335 µM 0.636398396077953 0.267473748384458 no 941 0.262258393019715 1292 54684039 YBR257W POP4
SGTC_2936 9038235 15.59 µM 0.635227132990241 0.267859214478278 no 942 0.262640144760691 1282 4749415
SGTC_2207 7258803 200 µM 0.63368020107451 0.268368742747787 no 943 0.263144774271721 1247 3666799
SGTC_285 1486-1325 46 µM 0.630872069774335 0.269294928623923 no 944 0.264062087723773 1312 22310230
SGTC_3109 9122853 49.47 µM 0.630719290793765 0.269345364564352 no 945 0.264112041703525 1364 1234709
SGTC_3153 9100258 49.47 µM 0.63061403028258 0.269380116294276 no 946 0.264146461421065 1255 25236848
SGTC_1030 k029-0042 36.7 µM 0.629952317052357 0.269598632215427 no 947 0.264362891014583 1340 6080581
SGTC_145 3737-0113 38.366 µM 0.62895092712681 0.269929487538784 no 948 0.264690591818453 1300 6849351
SGTC_1568 digitonin 820 nM 0.628700628519641 0.270012216957246 no 949 0.264772533284983 1335 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2203 7227154 166.4 µM 0.628280130545581 0.270151229718041 no 950 0.264910222770543 1284 896304
SGTC_2831 7999036 19.48 µM 0.625898332220573 0.270939305339041 no 951 0.265690814259439 1361 2988270
SGTC_710 3448-4187 58 µM 0.624253186760196 0.27148431050925 no 952 0.266230661186294 1332 3946412
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.623533553083443 0.271722882922148 no 953 0.266466980114955 1268 5355888
SGTC_464 bw-b 70c 158 µM 0.621025877350083 0.272555040211513 no 954 0.267291298532833 1334 5353454
SGTC_1801 st050089 28.441 µM 0.619698565505248 0.27299601225424 no 955 0.267728130141227 1320 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3219 9131112 49.47 µM 0.618714474648777 0.273323184370834 no 956 0.268052236364369 1257 17612988 YMR079W SEC14
SGTC_2255 7941087 197.44 µM 0.617061552885946 0.273873153523137 no 957 0.268597063392074 1350 935561
SGTC_1441 4106-0040 13 µM 0.616934402985698 0.273915482183627 no 958 0.268638996887511 1297 2904180
SGTC_1135 dihydrocapsaicin 536.708 nM 0.614446970433008 0.274744207346543 no 959 0.26946000266785 1268 107982 A Capsaicinoid.
SGTC_265 mycophenolic acid 32.932 µM 0.611909142531714 0.275590994540082 no 960 0.270298936192806 1402 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1762 st045503 25.4615 µM 0.611575422749686 0.275702440926859 no 961 0.270409351504663 1325 4645554
SGTC_2981 9013952 38.96 µM 0.611403001785493 0.275760029930172 no 962 0.270466407941078 1226 2996344
SGTC_2674 ligustilide 100 µM 0.611092763861674 0.275863665005072 no 963 0.270569085027107 1292 5319022 A signalling regulator.
SGTC_2774 tamoxifen 10.92 µM 0.611090602586154 0.275864387046943 no 964 0.270569800396318 1344 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1790 st045711 43.5 µM 0.610751181610895 0.275977792790347 no 965 0.270682158423883 1365 585119
SGTC_3304 9125678 46.087 µM 0.610395102819135 0.276096788769333 no 966 0.270800055701187 1326 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2199 6590217 200 µM 0.610295347155978 0.276130130072536 no 967 0.270833089282096 1302 703109
SGTC_1905 st060207 84.5 µM 0.607175087362965 0.277174010106165 no 968 0.271867361692543 1292 1948547
SGTC_197 4544-0043 41.561 µM 0.607049728911801 0.277215988968782 no 969 0.271908955278481 1326 896523
SGTC_2727 riluzole 51.77 µM 0.60704591387245 0.277217266562149 no 970 0.271910221147575 1330 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2119 5528445 120.635 µM 0.607007333885926 0.277230186521237 no 971 0.271923022546602 1385 791935
SGTC_1290 0986-0249 10.2 µM 0.606700800906602 0.277332851081056 no 972 0.272024745287336 1290 53329
SGTC_2998 9066762 71.4286 µM 0.606588971097909 0.277370309943447 no 973 0.272061860636493 1398 4945196
SGTC_2551 apiole 73.87 µM 0.606379935918604 0.277440335653811 no 974 0.27213124436145 1252 10659 A possible DNA adduct former.
SGTC_1495 4469-0029 237 µM 0.605730766460648 0.277657859161419 no 975 0.272346775135034 1330 793680
SGTC_1857 st056007 79.3 µM 0.603015776162368 0.27856849905973 no 976 0.273249097102963 1330 619834
SGTC_2394 5221648 200 µM 0.601036793534616 0.279233188582352 no 977 0.273907740134828 1447 788586
SGTC_3320 9137005 35.139 µM 0.600846202456913 0.279297243908486 no 978 0.273971213876431 1328 4908713
SGTC_2708 st078559 56 µM 0.597795621669689 0.280323477316293 no 979 0.274988156232436 1276 17250902
SGTC_885 0865-0106 16.8 µM 0.595563862114669 0.281075409266849 no 980 0.275733312213791 1294 2793380
SGTC_429 1112-0049 25.5 µM 0.59511641370957 0.281226282271857 no 981 0.275882828863618 1312 2836170
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.594412477133396 0.281463718428815 no 982 0.276118132639363 1372 4213774
SGTC_998 3996-0085 177 µM 0.593188459800309 0.281876806768139 no 983 0.276527517442295 1396 715391
SGTC_1686 st019653 115.5 µM 0.592065061198407 0.282256194625463 no 984 0.276903511007574 1385 97252
SGTC_2486 5283202 22.39 µM 0.590277239772691 0.282860473850875 no 985 0.277502397923723 1301 1377751
SGTC_2078 5212016 200 µM 0.589847907625528 0.283005679520546 no 986 0.277646310412285 1306 1899708
SGTC_2123 5259487 200 µM 0.588788542068588 0.283364123613257 no 987 0.278001566508767 1355 2173474
SGTC_1683 st010134 710 nM 0.58819884830126 0.283563745080524 no 988 0.278199415171024 1340 3818134
SGTC_2995 9067767 71.4286 µM 0.587371251589735 0.283844014369295 no 989 0.278477198602883 1362 11673567
SGTC_1048 3161-0300 24.5 µM 0.584791969732666 0.284718349221802 no 990 0.279343802275131 1350 2165101
SGTC_2689 tacrolimus 100 µM 0.584708221660866 0.28474675999859 no 991 0.279371962436918 1374 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2368 9071271 200 µM 0.583444337914498 0.285175685345804 no 992 0.279797108790198 1321 27209959
SGTC_401 neomycin 50 µM 0.583115214055417 0.285287430913431 no 993 0.279907871256659 1352 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_846 0335-0850 148 µM 0.58223373393977 0.285586817593255 no 994 0.28020462692012 1334 6819598
SGTC_1829 berberine 14.4 µM 0.580091113810352 0.286315161772443 no 995 0.280926587960897 1436 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_512 prima-1 270 µM 0.578712107074669 0.286784395627958 no 996 0.281391722671252 1428 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.578334725135452 0.286912870668391 no 997 0.28151907717518 1418 6708739 YPR165W RHO1
SGTC_3214 9129694 49.47 µM 0.576120657133904 0.2876671716642 no 998 0.282266814879667 1411 17158655
SGTC_61 0978-8327 98.565 µM 0.575381616061234 0.287919160743105 no 999 0.282516617294335 1388 6150059 YHR072W ERG7
SGTC_255 tunicamycin 200.472 nM 0.573465377116389 0.288573021210649 no 1000 0.283164817655943 1376 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3 0833-0587 95.581 µM 0.572018735519766 0.289067108287369 no 1001 0.283654640942028 1304 5382644
SGTC_1182 1222-0449 220 µM 0.570327271549868 0.289645316263 no 1002 0.284227873659987 1400 658318
SGTC_1002 4049-0206 172 µM 0.569191250777645 0.290033956712667 no 1003 0.284613178767375 1376 4662749
SGTC_1587 estradiol valerate 56.1 µM 0.567901260175495 0.290475567453946 no 1004 0.28505100811175 1392 13791 A steroid.
SGTC_2040 5100729 123 µM 0.56745597466454 0.290628077929606 no 1005 0.285202214789675 1408 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_933 2914-0560 114 µM 0.566387604644594 0.290994147787631 no 1006 0.285565159568001 1455 463887
SGTC_1646 st011709 75.6 µM 0.565922158684322 0.29115369708398 no 1007 0.285723348768158 1378 5757843
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.563113798366488 0.292117235035171 no 1008 0.286678698078974 1363 688662
SGTC_453 enantio-paf c16 10 µM 0.563061818506271 0.292135083111086 no 1009 0.286696394879585 1363 13871343 A lipid and platelet activating factor
SGTC_2913 7966556 36.57 µM 0.562204097621244 0.292429667876954 no 1010 0.286988484963378 1414 2976516
SGTC_794 k038-0031 316 µM 0.562119158144748 0.292458847905868 no 1011 0.287017418101334 1394 6624242
SGTC_1689 st020265 53.493 µM 0.561151605089949 0.292791335664212 no 1012 0.287347095484517 1458 5758320 YPR016C TIF6
SGTC_2355 9061122 103.12 µM 0.560437296814477 0.293036911510573 no 1013 0.287590598876279 1414 5302957
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.56039832113309 0.293050313916315 no 1014 0.287603888257394 1377 279621
SGTC_3149 9097855 49.47 µM 0.560320758362105 0.293076985950288 no 1015 0.287630335386618 1479 25236625 YMR079W SEC14
SGTC_1965 Pectolinarigenin 58.4 µM 0.559905636441741 0.293219755865384 no 1016 0.287771901993453 1382 5320438 An anti-inflammatory.
SGTC_161 4065-0411 162.148 µM 0.559463556976687 0.293371832538442 no 1017 0.287922697957019 1439 1906281 YLR208W SEC13
SGTC_3181 9108277 49.47 µM 0.558537027347314 0.29369068003993 no 1018 0.288238863771076 1341 17097298
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.55814622836878 0.293825214130404 no 1019 0.288372267766282 1479 165506
SGTC_2512 diallyl trisulfide 49.23 µM 0.555780841263299 0.294640115816627 no 1020 0.289180342127038 1365 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2129 girgensonine 121.053 µM 0.554855203267515 0.294959291780039 no 1021 0.289496852373108 1485 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2432 5630864 12.22 µM 0.554315783538677 0.295145366457047 no 1022 0.289681375150252 1378 5714970
SGTC_2214 7179297 48.276 µM 0.552997478028905 0.295600347754841 no 1023 0.290132568549333 1444 769744
SGTC_91 0417-1751 58.384 µM 0.552474538032377 0.295780917136429 no 1024 0.290311637268779 1448 6795624
SGTC_127 0180-0333 59.125 µM 0.551667581091294 0.296059655978659 no 1025 0.290588062543594 1381 771601
SGTC_815 1582-0027 36.9 µM 0.549476915078172 0.296816962429677 no 1026 0.291339101347011 1455 3128206
SGTC_1573 oleylamine 1.06 µM 0.54929910136547 0.296878470966022 no 1027 0.291400101984728 1413 5356789 An amine of the fatty acid oleic acid.
SGTC_2112 5488546 200 µM 0.54865132214883 0.297102597214429 no 1028 0.291622379014607 1385 600757
SGTC_2717 st081029 62.2815 µM 0.548154732324985 0.297274465555138 no 1029 0.29179283087288 1388 5292846
SGTC_2661 dactinomycin 12.96 µM 0.548117548615185 0.297287336560602 no 1030 0.29180559585448 1409 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1813 st051246 8.6015 µM 0.547298641906927 0.297570862663391 no 1031 0.292086788368059 1412 5291959
SGTC_218 alverine citrate 93.75 µM 0.546561884400279 0.297826052075832 no 1032 0.292339880582177 1446 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1982 st072467 71.9 µM 0.546309922941202 0.297913346423794 no 1033 0.292426458215126 1408 3163533
SGTC_2812 7970281 58.44 µM 0.545981530910805 0.298027138347405 no 1034 0.292539316396163 1525 2233435
SGTC_377 3970-0964 33.1 µM 0.545539609789392 0.298180300768547 no 1035 0.29269122295219 1454 16481235
SGTC_616 4092-0450 108 µM 0.544562074271436 0.298519225420789 no 1036 0.293027372403055 1451 787165
SGTC_1369 1866-0067 208 µM 0.544440073811017 0.298561536911877 no 1037 0.293069337807501 1495 3531355
SGTC_249 wiskostatin 11.211 µM 0.544397060008897 0.298576455359279 no 1038 0.293084134249146 1440 2775510 A n-wasp and actin depolymerizer.
SGTC_3232 9132874 49.47 µM 0.544365719827529 0.29858732526633 no 1039 0.293094915266573 1382 3784940
SGTC_2988 9073640 71.4286 µM 0.544086453419407 0.298684192891255 no 1040 0.293190990987659 1462 9102229
SGTC_1669 st015249 58.4 µM 0.543594700846753 0.298854799160338 no 1041 0.293360203579102 1470 722793
SGTC_3173 9105693 49.47 µM 0.538938314570905 0.300472453136182 no 1042 0.29496470935582 1460 17096658
SGTC_2185 6113692 200 µM 0.53820072000623 0.300729059958791 no 1043 0.295219241515331 1422 874150
SGTC_2367 9070478 135.38 µM 0.537979917031033 0.300805895845922 no 1044 0.295295456771805 1446 572802
SGTC_2563 tomatine 8.54 µM 0.537386488293658 0.301012443383418 no 1045 0.295500337291439 1516 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2212 7123476 200 µM 0.537150714066748 0.301094524199719 no 1046 0.295581756186468 1435 1085715
SGTC_2818 7996756 12.99 µM 0.536736122471832 0.301238881720189 no 1047 0.295724950317823 1399 2241621
SGTC_302 1094-0063 18.9 µM 0.536389335803401 0.301359654038072 no 1048 0.295844750054131 1383 5440289
SGTC_931 2812-0076 566 µM 0.536337756842448 0.301377618847542 no 1049 0.295862570249683 1434 3450959
SGTC_300 r073-0011 5.04 µM 0.535294102946847 0.301741224132991 no 1050 0.296223251741566 1461 2735780
SGTC_3229 9132204 49.47 µM 0.533446171048285 0.302385520261359 no 1051 0.296862381848309 1467 17682924
SGTC_286 k060-0067 22.9 µM 0.532849509076224 0.30259368289481 no 1052 0.297068879468653 1398 5985051
SGTC_1917 st066507 28.5 µM 0.530248609108945 0.303501830538859 no 1053 0.297969786320187 1444 3156428
SGTC_1201 1889-3372 45.9 µM 0.528590781008392 0.304081323398892 no 1054 0.298544678453603 1422 5392199
SGTC_2098 5376439 882.5 nM 0.525874965494312 0.305031699074242 no 1055 0.299487541984717 1541 2844116
SGTC_2346 9031566 143.75 µM 0.525666762268023 0.305104612365969 no 1056 0.299559880638517 1508 4771086
SGTC_1515 3460-0031 42.1 µM 0.522934374252712 0.306062217639166 no 1057 0.300509961344826 1408 2876596
SGTC_374 0880-0231 82.3 µM 0.521940343163212 0.306410919867915 no 1058 0.300855933924806 1418 6833587
SGTC_460 trequinsin 123 µM 0.519492495139389 0.30727036264552 no 1059 0.301708672522655 1477 5537 A vasodilator.
SGTC_566 0958-0068 16.5 µM 0.517581509606268 0.307942049093774 no 1060 0.302375142716379 1463 6815365
SGTC_1853 st056710 91.2 µM 0.517364091599781 0.308018509524042 no 1061 0.302451010657607 1619 269167
SGTC_345 1362-0200 395 µM 0.516646389067422 0.308270966555816 no 1062 0.302701513288909 1423 1419823
SGTC_2867 9039098 71.43 µM 0.514758979790691 0.308935309086989 no 1063 0.303360726581509 1428 6463460
SGTC_2136 5328288 199.296 µM 0.51469489608652 0.308957876675518 no 1064 0.303383120281364 1429 262395
SGTC_166 k072-0058 166.424 µM 0.514227510372948 0.309122492095457 no 1065 0.303546467996626 1458 5846229
SGTC_773 4358-1457 44.6 µM 0.512087315001461 0.30987676809683 no 1066 0.30429495097307 1588 1186886
SGTC_1570 verbenone 133 µM 0.511937106024567 0.309929736853164 no 1067 0.304347513882025 1528 29025 A natural terpanoid with antifungal properties.
SGTC_639 0833-0042 114 µM 0.504411576608281 0.312588524394282 no 1068 0.306986092311225 1444 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_56 0957-0365 83.25 µM 0.503179742788715 0.313024669648801 no 1069 0.30741895286721 1436 6752360
SGTC_2402 5553605 200 µM 0.501981150578414 0.313449296621938 no 1070 0.307840390102493 1557 6758546
SGTC_970 1315-0089 19.5 µM 0.501922695903712 0.313470011773617 no 1071 0.307860949852115 1415 6811083 YLR033W RSC58
SGTC_2075 5212009 200 µM 0.500791357543705 0.313871050976857 no 1072 0.30825898431552 1516 780898
SGTC_1049 3226-0134 66 µM 0.500493856253668 0.313976546408663 no 1073 0.308363690534619 1490 5702385
SGTC_1034 k072-0165 12.7 µM 0.499872129300292 0.314197062952589 no 1074 0.308582559004719 1587 5835461
SGTC_664 1222-0054 14.9 µM 0.499457190541969 0.314344271970411 no 1075 0.308728669041477 1450 6813991
SGTC_1230 0170-0365 3.77 µM 0.499078938300062 0.314478491338184 no 1076 0.308861887249008 1538 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1071 trifluoperazine 6.31 µM 0.498625152391519 0.314639545500342 no 1077 0.309021741153073 1558 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_769 0302-0231 76 µM 0.498495595837433 0.314685533177993 no 1078 0.309067386320492 1489 571869 YER009W NTF2
SGTC_575 k072-0246 11.9 µM 0.496814580024477 0.31528249063516 no 1079 0.309659906318991 1493 6796779
SGTC_2013 4024628 200 µM 0.495674046940899 0.315687788339421 no 1080 0.310062200359732 1511 5230760
SGTC_431 k089-0097 107 µM 0.495363866215121 0.315798051958195 no 1081 0.310171648087095 1435 5499420
SGTC_702 1488-0190 94 µM 0.49529082903024 0.31582401773698 no 1082 0.310197421812281 1575 949357
SGTC_389 tpck 16.7 µM 0.49385061652223 0.316336219710306 no 1083 0.310705841497386 1481 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1237 0330-0133 46.1 µM 0.493244194079334 0.316551995345125 no 1084 0.310920027279315 1465 X1237 YHR072W ERG7
SGTC_2006 4011487 200 µM 0.492621015633121 0.316773798121253 no 1085 0.311140197964298 1602 45595294
SGTC_3349 9149703 23.001 µM 0.491459747544899 0.317187294444182 no 1086 0.311550657529279 1448 4910494
SGTC_3150 9097574 49.47 µM 0.486592602604769 0.318922833032897 no 1087 0.313273533424138 1616 17217476
SGTC_2318 6029776 164 µM 0.485669023228809 0.319252615442156 no 1088 0.313600924891634 1581 818325
SGTC_1359 1582-0056 520 nM 0.485200713070406 0.319419889590917 no 1089 0.313766988145348 1545 3661189
SGTC_2706 st078239 82.5 µM 0.484121935831008 0.319805354259448 no 1090 0.314149667185643 1476 15434492
SGTC_3018 9082602 49.47 µM 0.48347579366042 0.320036324629249 no 1091 0.314378971576945 1511 17332089
SGTC_263 alizarin 107.927 µM 0.48202432345907 0.320555422336617 no 1092 0.314894333719851 1542 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2353 9059630 146.67 µM 0.480883146838621 0.320963794619448 no 1093 0.315299775670326 1569 4779114
SGTC_1007 4101-0031 70 µM 0.479574425259073 0.32143238991793 no 1094 0.315765017630465 1605 1146276
SGTC_2004 4023728 41.89 µM 0.477592782818099 0.322142469476001 no 1095 0.316470034339364 1576 360084 YDR527W RBA50
SGTC_2464 5717415 7.67 µM 0.477448038636273 0.322194360975809 no 1096 0.3165215567317 1435 5285744
SGTC_558 k064-0027 21.3 µM 0.476977880261922 0.322362938969689 no 1097 0.316688936444374 1586 5088526
SGTC_1880 MG-132 525 µM 0.476719119325984 0.322455734784692 no 1098 0.316781073188889 1586 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1217 1183-1422 255 µM 0.476002996533707 0.322712605543913 no 1099 0.317036121548158 1605 2849664
SGTC_3075 9116269 49.47 µM 0.473796583758296 0.323504569746059 no 1100 0.317822485478947 1541 17015205 YNL244C SUI1
SGTC_2065 5221596 34.26 µM 0.473735809372006 0.323526395289817 no 1101 0.317844157079741 1554 788581
SGTC_2046 4110841 106 µM 0.471394956169781 0.324367513423542 no 1102 0.318679358591515 1542 44119630 YMR134W ERG29
SGTC_2383 9036125 200 µM 0.47122296464587 0.324429349042743 no 1103 0.318740760480123 1553 79580
SGTC_1192 1488-0095 21.4 µM 0.470762068019765 0.324595077750711 no 1104 0.31890532755945 1529 915875
SGTC_422 cantharidin 155 µM 0.469325161872389 0.325111981749923 no 1105 0.319418616268349 1464 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3010 9080089 71.4286 µM 0.468237997673171 0.325503295535527 no 1106 0.319807201012062 1608 17027233
SGTC_1866 st057638 64 µM 0.467680235316365 0.325704131180408 no 1107 0.320006638646301 1527 688802
SGTC_883 0850-0245 24.6 µM 0.467562020650685 0.325746703691908 no 1108 0.320048915040734 1597 6823229 YPR165W RHO1
SGTC_466 geldanamycin 89.2 µM 0.467047679554399 0.325931959206787 no 1109 0.320232882925587 1526 5288382 HSP90 inhibitor.
SGTC_1101 ebselen 5.29 µM 0.465707991722008 0.32641469000872 no 1110 0.32071226559482 1655 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1794 st048918 76.9 µM 0.465363571889972 0.326538842121902 no 1111 0.32083555827421 1556 672303
SGTC_865 0488-0499 301 µM 0.464707816565637 0.326775273634867 no 1112 0.321070354988093 1537 9634651
SGTC_630 4356-0227 183 µM 0.462313027161465 0.327639301445227 no 1113 0.321928429464546 1541 779312
SGTC_1797 st048695 56.8 µM 0.461699541641978 0.327860792717601 no 1114 0.32214839991293 1620 592262 YIL048W NEO1
SGTC_1624 st003710 6.25 µM 0.461350769028696 0.327986739715979 no 1115 0.322273483085962 1627 24207033
SGTC_3162 9099653 49.47 µM 0.461097342302414 0.328078268164061 no 1116 0.322364384211474 1544 25237511
SGTC_2313 7726885 200 µM 0.459812106855485 0.328542606970854 no 1117 0.3228255461895 1547 726423
SGTC_2571 chrysanthemic acid 100 µM 0.458867327264384 0.328884112506736 no 1118 0.323164721330123 1475 2743 An insecticide.
SGTC_2076 5212012 200 µM 0.458810107665777 0.328904800028607 no 1119 0.323185267847484 1510 604802
SGTC_2246 7293507 91.5585 µM 0.45845063511424 0.329034777910355 no 1120 0.323314360240927 1670 887656
SGTC_2037 5169046 200 µM 0.457877702527567 0.329241981278988 no 1121 0.323520153550437 1574 5718022
SGTC_2152 5568786 200 µM 0.457549708588159 0.329360625220391 no 1122 0.323637990946646 1526 5399883
SGTC_303 1348-1668 34.2 µM 0.457458511519072 0.329393616626539 no 1123 0.323670758186145 1561 5380509
SGTC_304 1310-0298 97 µM 0.457042098379384 0.329544274911039 no 1124 0.323820393401124 1479 1550234
SGTC_1937 st074714 47.2 µM 0.456772300467513 0.329641902575908 no 1125 0.323917358642131 1471 17250970
SGTC_3283 9109332 35.8195 µM 0.456156395466691 0.329864814241931 no 1126 0.324138759376233 1493 17027281
SGTC_2958 9077254 16.72 µM 0.455651539056108 0.330047579679224 no 1127 0.324320287627883 1538 16457351
SGTC_633 0437-0093 97.7 µM 0.452463858881174 0.33120250198651 no 1128 0.325467425884021 1549 2831118
SGTC_347 4534-1311 26.2 µM 0.450735830536515 0.331829253328321 no 1129 0.32608997748016 1523 2862016
SGTC_2969 9091408 28.7 µM 0.449401180647605 0.332313649794474 no 1130 0.32657113988768 1470 4286311
SGTC_1767 st044992 70.3 µM 0.448800442032811 0.33253177276276 no 1131 0.326787809920069 1499 9600693
SGTC_1921 5740136 50 µM 0.44809887229775 0.332786578427265 no 1132 0.327040920939891 1687 1774243
SGTC_3100 9120536 49.47 µM 0.446505599467348 0.333365531765794 no 1133 0.327616034375476 1544 16421196
SGTC_1355 1499-0035 1.68 µM 0.446370017147099 0.333414817163503 no 1134 0.32766499356544 1527 1548538
SGTC_382 3229-0966 23.2 µM 0.446309957410131 0.33343665033941 no 1135 0.327686682266958 1639 5722370
SGTC_541 4513-1321 94 µM 0.445763381333018 0.333635369969891 no 1136 0.327884087889076 1509 747515
SGTC_858 0438-0351 2.77 µM 0.445454413399183 0.333747722644317 no 1137 0.32799569840971 1532 2799119
SGTC_18 0111-0177 500 nM 0.445429471678883 0.33375679306763 no 1138 0.328004708941752 1590 721752
SGTC_1859 st055998 20 µM 0.44400291063596 0.334275744508041 no 1139 0.328520239775661 1699 676301
SGTC_2066 5222451 176 µM 0.443340898269438 0.334516677727927 no 1140 0.328759588912375 1507 2281147
SGTC_973 1325-0077 65.9 µM 0.441342350955062 0.335244443555888 no 1141 0.32948258523026 1684 2835149
SGTC_59 0330-0160 1.33 µM 0.439700094671388 0.335842930276365 no 1142 0.330077167005939 1591 4293482
SGTC_2630 antimycin a 100 µM 0.43883043651243 0.336160028205696 no 1143 0.330392202297194 1499 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_776 4476-4378 112 µM 0.43789624278399 0.336500787251562 no 1144 0.330730749680709 1556 2892008
SGTC_271 rotenone 740 µM 0.437629793901488 0.336598002502253 no 1145 0.330827334893132 1607 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3033 9090887 49.47 µM 0.437425292605387 0.336672623264772 no 1146 0.330901472328339 1523 19325384
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.43657129074184 0.336984310670501 no 1147 0.33121114352067 1543 688803
SGTC_1176 0848-0131 83.3 µM 0.436407649768669 0.337044047954856 no 1148 0.331270494865324 1695 6769040
SGTC_1416 3966-0321 25.3 µM 0.436342796266413 0.337067723921385 no 1149 0.331294017913497 1581 582530 YLR208W SEC13
SGTC_2477 5967686 25.23 µM 0.435331705387467 0.337436924705248 no 1150 0.331660837259934 1512 776118
SGTC_364 0083-0097 67.7 µM 0.434810930039815 0.33762714742167 no 1151 0.331849835307775 1600 5207356
SGTC_1362 1611-0397 101 µM 0.434325000166021 0.337804679614626 no 1152 0.332026225954938 1561 27816
SGTC_1107 amlodipine 47 µM 0.433688457789174 0.338037291977324 no 1153 0.332257344676903 1522 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_372 0155-0182 15.9 µM 0.433514804559517 0.338100761005334 no 1154 0.332320406568861 1645 771486
SGTC_55 0767-0285 6.563 µM 0.432214174340297 0.338576278359437 no 1155 0.332792879183302 1593 3116166
SGTC_262 fenpropimorph 62.5 µM 0.430703260068961 0.339128999942471 no 1156 0.333342074035922 1541 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3240 9133527 49.47 µM 0.429842982486991 0.339443860924699 no 1157 0.333654931928188 1568 17617455
SGTC_1643 st009866 20.2 µM 0.428371137018416 0.339982815218313 no 1158 0.334190467476977 1648 3156273 YOR207C RET1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.425840163097186 0.340910361391746 no 1159 0.335112159454692 1607 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3143 9086658 49.47 µM 0.42496035313612 0.341233018089618 no 1160 0.335432788451457 1579 25236626
SGTC_2179 6298986 200 µM 0.4247119829065 0.341324125056515 no 1161 0.335523323683038 1692 738374
SGTC_203 k066-0004 30.888 µM 0.424151796700118 0.341529646056721 no 1162 0.335727556270988 1653 6795412
SGTC_1177 0983-0204 23.6 µM 0.421941212281017 0.342341122951783 no 1163 0.33653396387732 1725 766818
SGTC_2617 dihydrotanshinone i 20.83 µM 0.42147583233802 0.342512050841476 no 1164 0.336703827615267 1562 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1126 isoteolin 1.0172 µM 0.420126816263182 0.343007708751175 no 1165 0.33719640683473 1515 133323
SGTC_1630 st005209 31.3 µM 0.420030417294616 0.343043138190177 no 1166 0.337231616616894 1655 3367314
SGTC_2619 obliquin 87.91 µM 0.419789871504868 0.343131551817285 no 1167 0.337319482330349 1680 6708593 A bioactive alkalod. YER133W GLC7
SGTC_253 dyclonine 31.25 µM 0.418068782254821 0.343764395783515 no 1168 0.337948414321609 1658 3180 An oral anasthetic.
SGTC_305 1682-2595 20.8 µM 0.415345644135988 0.344766587118113 no 1169 0.338944445912785 1630 226033
SGTC_1747 st037496 66.6 µM 0.415018778344634 0.34488695633912 no 1170 0.339064078227088 1596 723305
SGTC_1572 epiandrosterone 68.9 µM 0.414491439386548 0.345081183445467 no 1171 0.33925711758267 1655 441302 A steroid.
SGTC_1038 k292-0204 154 µM 0.413511400725655 0.345442255257046 no 1172 0.339615985666522 1544 4454212
SGTC_715 0868-0130 184 µM 0.412631015450814 0.345766732135789 no 1173 0.339938486961774 1763 2876258
SGTC_1194 1488-0194 225 µM 0.409650314997746 0.346866146269442 no 1174 0.341031241010836 1610 1391452
SGTC_1169 aniline yellow 25.8 µM 0.40723593918553 0.347757621459095 no 1175 0.341917353973841 1684 6051 A DNA damaging agent.
SGTC_1092 toremifene 6.32 µM 0.406047549857809 0.348196727621697 no 1176 0.342353831473448 1618 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_173 1273-0061 2.693 µM 0.40165729131261 0.349820675808164 no 1177 0.343968130019235 1549 2847414 YPL266W DIM1
SGTC_2914 7968218 45.32 µM 0.399835008915733 0.350495544314347 no 1178 0.34463902168421 1714 2977111
SGTC_3314 9135860 59.4275 µM 0.399076789983333 0.350776484194902 no 1179 0.344918311808022 1748 25252478
SGTC_3176 9106582 49.47 µM 0.398854838708385 0.350858738377327 no 1180 0.34500008361123 1632 17018027
SGTC_524 r073-0010 27.8 µM 0.398457259875881 0.351006096846492 no 1181 0.345146578622283 1583 2772106
SGTC_2142 5622915 118.518 µM 0.39630006730258 0.35180602804983 no 1182 0.345941838795551 1611 5322196
SGTC_2620 irigenin 100 µM 0.393078469133756 0.353001884117701 no 1183 0.347130762983682 1733 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_337 1315-0038 354 µM 0.392729305769465 0.353131580938233 no 1184 0.347259711681679 1633 1626437
SGTC_2908 7930301 100 µM 0.391318050566209 0.353655965756892 no 1185 0.347781079051081 1551 2223178
SGTC_988 1497-1057 103 µM 0.389990615956862 0.354149458677022 no 1186 0.348271743010903 1743 3533044
SGTC_2072 5231554 129 µM 0.389479557835397 0.35433951726912 no 1187 0.348460714861053 1794 789545
SGTC_966 1300-0360 30.2 µM 0.38882087969154 0.354584528125622 no 1188 0.348704327037365 1646 70588
SGTC_140 0062-0056 502.533 µM 0.388536334386029 0.354690390076331 no 1189 0.348809585452287 1546 3758964
SGTC_2576 guaiol 23.12 µM 0.387459048588095 0.355091284026251 no 1190 0.349208198175975 1811 227829
SGTC_198 3454-2873 16.191 µM 0.385766408505871 0.355721495804825 no 1191 0.349834837686621 1675 710957
SGTC_3000 9075062 71.4286 µM 0.385426407905612 0.355848134082295 no 1192 0.349960760175592 1648 17057871
SGTC_1219 1469-0211 33.1 µM 0.382694360468685 0.356866302205854 no 1193 0.350973198209771 1769 6822282
SGTC_3069 9117009 49.47 µM 0.38268021350842 0.356871577098291 no 1194 0.350978443530901 1658 41904981
SGTC_3256 9138902 49.47 µM 0.382580175590209 0.356908878419263 no 1195 0.351015535772624 1722 17228773
SGTC_144 4161-2749 112.381 µM 0.380942270468323 0.357519801422699 no 1196 0.351623042892551 1638 797501 YMR168C CEP3
SGTC_557 1315-0110 16.2 µM 0.380902304975793 0.357534712742102 no 1197 0.351637871036114 1593 6833801
SGTC_1419 3993-2473 62.6 µM 0.380348922507682 0.357741204774341 no 1198 0.351843212221263 1687 704026
SGTC_3190 9110366 49.47 µM 0.37930863697053 0.358129495045372 no 1199 0.352229343335762 1787 17123768
SGTC_724 3910-0327 137 µM 0.37743273052252 0.358830054569391 no 1200 0.352926023488796 1615 2885483
SGTC_818 4072-2707 53.5 µM 0.376606941869828 0.359138597101037 no 1201 0.353232864070951 1587 882871
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.376599077251159 0.359141536030291 no 1202 0.353235786808238 1715 5393153
SGTC_2827 7993847 71.43 µM 0.376170126964518 0.359301843079227 no 1203 0.353395211204643 1686 2985692
SGTC_2168 5727979 200 µM 0.37497811715801 0.359747450267921 no 1204 0.353838370606925 1593 695210
SGTC_3340 9146634 11.102 µM 0.37470081358838 0.359851141602057 no 1205 0.353941493558093 1644 4907387
SGTC_1077 5-fluorocytosine 377 nM 0.372332951288294 0.360736969016229 no 1206 0.35482248391394 1682 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1872 amphotericin b 148 nM 0.372088226060026 0.360828564483481 no 1207 0.354913581122963 1748 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_42 0133-0086 60.653 µM 0.37045003348658 0.361441910601681 no 1208 0.35552359994393 1564 162923 Model of phenazepam hydroxylation.
SGTC_152 4469-0003 551.229 µM 0.369594179309594 0.361762487752856 no 1209 0.35584244436274 1728 697280
SGTC_1999 st074831 12.5 µM 0.368429761380805 0.362198799364531 no 1210 0.356276404686523 1657 17112523
SGTC_2683 piperine 63.03 µM 0.368050537261603 0.362340934704534 no 1211 0.356417775798374 1676 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_792 4534-1957 155 µM 0.367415539751762 0.362578977844146 no 1212 0.356654540951752 1711 1717904
SGTC_3088 9117578 49.47 µM 0.365954220715535 0.363126987936544 no 1213 0.357199618047852 1706 678341
SGTC_2302 7771753 200 µM 0.365689993000736 0.363226106083332 no 1214 0.357298207062763 1620 2203047
SGTC_646 4092-0839 27.3 µM 0.365471056063675 0.363308241513872 no 1215 0.357379904336721 1756 877796
SGTC_837 0091-0265 12.5 µM 0.365244089739009 0.363393395850013 no 1216 0.357464604712979 1650 759367
SGTC_1815 st051655 58.2 µM 0.364808675054807 0.363556775756962 no 1217 0.357627114496141 1776 5984156
SGTC_1729 st035615 45.989 µM 0.363463847849701 0.364061549556724 no 1218 0.358129207116168 1665 17385451
SGTC_2222 6885208 172.143 µM 0.363242259581901 0.364144744208599 no 1219 0.358211960901262 1709 609514
SGTC_1242 0402-0103 60.1 µM 0.362649281975735 0.364367407357602 no 1220 0.358433445548074 1648 432868
SGTC_1730 st033808 45.1 µM 0.362136614178643 0.364559951068213 no 1221 0.358624971860189 1677 1045166
SGTC_956 1185-0240 191 µM 0.359771574652567 0.365448635670105 no 1222 0.359508980953096 1697 1416193
SGTC_2791 5663188 71.43 µM 0.359123026380654 0.365692459931161 no 1223 0.359751528244595 1783 54690634
SGTC_2532 xanthone 78.9 µM 0.35908224087035 0.365707795218188 no 1224 0.359766783300681 1753 7020 An insecticide.
SGTC_1967 st070177 51.4 µM 0.358550930157582 0.365907586801529 no 1225 0.359965530523876 1742 5729214
SGTC_202 3594-0513 34.79 µM 0.35756535698454 0.366278293377813 no 1226 0.360334303785458 1704 708429
SGTC_2728 chlorpromazine 9.18 µM 0.355864041886922 0.366918507655167 no 1227 0.360971192852258 1720 2726 A thorazine and dopamine antagonist.
SGTC_716 1683-5115 658 µM 0.354276728676797 0.367516156379926 no 1228 0.361565753036895 1755 723597
SGTC_1867 st057372 64 µM 0.353979867343269 0.367627965079834 no 1229 0.361676985600503 1713 688837
SGTC_687 k029-0044 34.9 µM 0.353938766787872 0.367643445917899 no 1230 0.361692386709235 1829 5829338
SGTC_2034 5197015 53.07 µM 0.353256488234298 0.367900462744334 no 1231 0.361948081323538 1803 780676
SGTC_496 calpeptin 138 µM 0.351750425295917 0.368468011426462 no 1232 0.362512720126405 1650 73364 A calpain inhibitor.
SGTC_1259 0671-0132 43 µM 0.349902224037103 0.369164884638906 no 1233 0.363206038938353 1690 X1259
SGTC_1891 st059073 26.2 µM 0.3494108387822 0.369350236314277 no 1234 0.363390448666668 1837 688754
SGTC_2140 5586273 200 µM 0.347063284394846 0.370236157853039 no 1235 0.364271887948098 1709 854421
SGTC_572 0960-0087 17.7 µM 0.346815759207364 0.37032960928745 no 1236 0.364364868494527 1633 6796365
SGTC_1098 clofazimine 15.1 µM 0.34542629501498 0.370854333877531 no 1237 0.364886955886786 1779 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2453 5731132 22.18 µM 0.345402649828198 0.370863265452474 no 1238 0.364895842672867 1847 1362040
SGTC_2159 5658611 73.75 µM 0.345353563882876 0.370881807071786 no 1239 0.36491429132285 1810 793844
SGTC_3001 9076041 71.4286 µM 0.344529288586597 0.37119321180552 no 1240 0.365224136802239 1688 16004211
SGTC_458 nppb 133 µM 0.343500610603506 0.371581956573396 no 1241 0.365610940773468 1858 4549 A chloride channel blocker.
SGTC_1417 3966-0327 90.4 µM 0.341769399216305 0.372236489328069 no 1242 0.366262220117162 1721 651118
SGTC_1602 st001878 87.6 µM 0.340598358673299 0.37267944337634 no 1243 0.366702982617429 1785 595405 YLR310C CDC25
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.340226474384714 0.372820146402093 no 1244 0.36684299122575 1674 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2309 7664088 163.95 µM 0.33906970163939 0.373257921663022 no 1245 0.367278611222554 1869 704922
SGTC_495 decylubiquinone 155 µM 0.338746687176319 0.373380194237527 no 1246 0.367400283256718 1692 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2656 pseudo-anisatin 100 µM 0.337928489929607 0.373689968305038 no 1247 0.36770853867536 1745 6708809 A neurotoxin.
SGTC_986 1493-0483 84 µM 0.337720700683836 0.373768651483004 no 1248 0.367786836753757 1815 40079
SGTC_3263 9137018 49.47 µM 0.337457470922416 0.37386833577452 no 1249 0.367886033532079 1623 43844957
SGTC_1313 1220-0047 237 µM 0.335898333969481 0.3744589488651 no 1250 0.368473766720568 1776 3528706
SGTC_1114 scopoletin 1.73284 µM 0.334899772897743 0.374837366392646 no 1251 0.368850346710702 1832 5280460 A coumarin with genotoxic properties.
SGTC_920 mycophenolic acid 780.421 nM 0.333711025879757 0.375288014470313 no 1252 0.369298814324921 1687 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1089 terbinafine 2.25 µM 0.333536376828904 0.375354237415342 no 1253 0.369364717565553 1817 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2495 cafestol 54.53 µM 0.333281993402169 0.375450700392327 no 1254 0.369460715176472 1778 16667697 An anti-infammatory.
SGTC_1061 3448-9325 110 µM 0.331278041825255 0.376210876853839 no 1255 0.370217237931093 1803 723482
SGTC_3350 9150499 3.57 µM 0.331210099682131 0.376236658378456 no 1256 0.370242895962965 1720 4910996 YPR165W RHO1
SGTC_1704 st028805 70.8 µM 0.330934275500934 0.376341329100957 no 1257 0.370347065601012 1711 2876101
SGTC_449 xestospongin c 11.1929 µM 0.330738490383301 0.376415631839815 no 1258 0.370421012912186 1783 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2298 7976326 193.81 µM 0.3307134674097 0.376425128680684 no 1259 0.370430464341471 1777 2235818
SGTC_2375 9072683 200 µM 0.330080796553201 0.376665267848193 no 1260 0.370669456473857 1893 16798029
SGTC_2186 6124449 200 µM 0.329500687933011 0.376885498227602 no 1261 0.370888637030493 1800 3834182 YLR033W RSC58
SGTC_3334 9142812 21.919 µM 0.328650033755208 0.377208509993709 no 1262 0.371210112685537 1777 45283678
SGTC_54 0159-0055 9 µM 0.326982278431727 0.377842041926329 no 1263 0.37184064444806 1853 3319099
SGTC_1579 chlormadinone acetate 49.4 µM 0.326181948257891 0.37814618100246 no 1264 0.372143349184857 1861 45114258 A steroidal progestin.
SGTC_221 trifluoperazine 10.304 µM 0.324991110017149 0.378598859531567 no 1265 0.372593899997392 1736 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1375 2910-0797 186 µM 0.324838704175876 0.378656806268232 no 1266 0.372651574984965 1748 742508
SGTC_2481 5478948 45.16 µM 0.324453345415374 0.378803336984047 no 1267 0.372797419149636 1737 77792
SGTC_1438 4092-1045 4 µM 0.323022653829864 0.37934750246819 no 1268 0.373339042847984 1731 1351342
SGTC_1340 1486-1359 257 µM 0.3221355446594 0.379685035818184 no 1269 0.373675005786832 1762 4309068
SGTC_2462 5162487 171.77 µM 0.319906246470108 0.380533658641317 no 1270 0.374519701259449 1870 2259986
SGTC_2890 9046729 58.44 µM 0.319517042941741 0.380681875122518 no 1271 0.374667234883462 1688 903329
SGTC_1722 st034304 3.6505 µM 0.317507219589873 0.381447534309426 no 1272 0.37542938111275 1724 4036148 YLR033W RSC58
SGTC_306 1672-3436 11.6 µM 0.317423577244943 0.381479408648824 no 1273 0.375461109736697 1795 6797378
SGTC_3114 9122766 49.47 µM 0.316604796490142 0.381791471199582 no 1274 0.375771747906495 1712 17176985
SGTC_1305 1181-0477 144 µM 0.316259823319383 0.381922974112176 no 1275 0.375902651798751 1871 6252086
SGTC_2370 9071495 200 µM 0.315999623970432 0.38202217047049 no 1276 0.37600139677481 1723 21791103
SGTC_990 3985-0011 41.3 µM 0.315716700066746 0.382130038949379 no 1277 0.376108774874142 1750 5399565 YGL099W LSG1
SGTC_1559 coumarin 343 70.1 µM 0.313524428619151 0.382966180953941 no 1278 0.376941132104926 1817 108770 A hepatotoxic, DNA x-linker.
SGTC_2954 9074818 52.69 µM 0.313191706716266 0.383093130342227 no 1279 0.377067509399994 1813 16648742
SGTC_1174 0739-0097 51.1 µM 0.311441176337172 0.383761248296236 no 1280 0.377732627531679 1763 728447
SGTC_217 ketoconazole 989 nM 0.310963667862323 0.383943557146823 no 1281 0.377914121041154 1784 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2895 9054447 58.44 µM 0.309983105635384 0.384318008317721 no 1282 0.378286901877475 1761 2697450
SGTC_2204 7233102 200 µM 0.309653937069878 0.384443733444587 no 1283 0.378412067480081 1817 2172480
SGTC_362 0310-0100 9.03 µM 0.308818550452768 0.384762861862958 no 1284 0.378729778601107 1742 790235
SGTC_889 0919-1524 82.7 µM 0.308607088548332 0.384843655420998 no 1285 0.37881021401287 1747 3905452
SGTC_3141 9094609 49.47 µM 0.307368661441869 0.385316923365394 no 1286 0.379281389464901 1694 25236309 YDL196W YDL196W
SGTC_1365 1672-3266 55.4 µM 0.307355131902291 0.385322094656674 no 1287 0.379286537943281 1879 6415873
SGTC_2289 7946404 165.07 µM 0.306930749794049 0.385484313294355 no 1288 0.379448041524157 1715 1246120 YPR165W RHO1
SGTC_2409 alverine citrate 63.97 µM 0.305956633444152 0.385856741734397 no 1289 0.379818832432797 1868 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_371 0195-0006 7.36 µM 0.304206800518039 0.386526009640257 no 1290 0.380485172076208 1695 3928593
SGTC_1633 st005664 67.9 µM 0.30294560821084 0.387008594096 no 1291 0.380965656580502 1724 2063822
SGTC_861 0443-0273 110 µM 0.30292210974601 0.38701758724299 no 1292 0.380974610685606 1829 6149169
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.302260330246356 0.387270883159774 no 1293 0.381226808345665 1814 1377
SGTC_1912 st060209 90.8 µM 0.302249323385129 0.387275096438931 no 1294 0.381231003379069 1697 688787
SGTC_2488 5268135 45.7 µM 0.301345728193895 0.387621025831848 no 1295 0.381575437219005 1861 1270356 YLR208W SEC13
SGTC_2 0422-0095 29 µM 0.300940733202159 0.38777610174983 no 1296 0.381729844306319 1765 6790840
SGTC_444 curcumin 90.4 µM 0.30040535782738 0.387981128861446 no 1297 0.381933988678794 1817 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_379 3970-0972 5.9 µM 0.298274478050009 0.388797478607878 no 1298 0.382746840893881 1801 2898042 YBL034C STU1
SGTC_1963 st076565 50.3 µM 0.293473814683252 0.390638429744125 no 1299 0.384580005827794 1754 4914280
SGTC_2295 7971645 200 µM 0.293456280383523 0.390645158293996 no 1300 0.38458670617634 1844 2978226 YKL099C UTP11
SGTC_2977 9011197 71.43 µM 0.292922748700686 0.390849909494177 no 1301 0.384790600097844 1856 2704722
SGTC_2107 5363541 170.161 µM 0.292492818283005 0.391014924096479 no 1302 0.384954925054888 1824 244052
SGTC_275 trichlorophene 5.69 µM 0.292309525513055 0.391085280945297 no 1303 0.385024988203129 1819 62616
SGTC_2871 9038510 12.99 µM 0.289234206895362 0.392266270555756 no 1304 0.386201078322149 1945 4945164
SGTC_1766 st045414 44.774 µM 0.288684867276995 0.392477333827066 no 1305 0.386411272027327 1794 253960
SGTC_2277 7947813 106.88 µM 0.288566475420376 0.392522825629826 no 1306 0.386456576647538 1900 1246798
SGTC_2389 9091542 195.52 µM 0.288194382731635 0.392665810960714 no 1307 0.386598974200146 1772 3626624 YOL127W RPL25
SGTC_2200 6600604 21.907 µM 0.287358994212421 0.392986881314021 no 1308 0.386918727780586 1797 2904777
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.286851704724361 0.393181886761422 no 1309 0.387112935545491 1923 6728940
SGTC_1196 1588-0294 184 µM 0.286597637801795 0.393279561850572 no 1310 0.387210211677184 1756 6144269
SGTC_2584 androsterone 48.74 µM 0.286471226756924 0.393328162612566 no 1311 0.387258614074022 1843 2754130 A steroid.
SGTC_2261 9010538 184.68 µM 0.286213208938936 0.393427366876347 no 1312 0.387357413735251 1743 6457250
SGTC_84 0443-0269 128.823 µM 0.286110633741508 0.393466807536153 no 1313 0.387396693649752 1876 6150058
SGTC_1331 1472-0049 76.2 µM 0.284737136187073 0.393995029160205 no 1314 0.387922768615249 1756 24051409
SGTC_1709 st033179 39.1045 µM 0.284205881719775 0.394199392122128 no 1315 0.38812630414144 1788 573381
SGTC_2164 5685496 200 µM 0.283932121779228 0.3943047134698 no 1316 0.388231199729713 1891 759046
SGTC_2993 9054257 71.4286 µM 0.28374274374334 0.394377575803356 no 1317 0.388303767785969 1791 6470217 YGL055W OLE1
SGTC_570 0987-0065 62.6 µM 0.281967921053593 0.395060610019014 no 1318 0.388984053978047 1925 3104428
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.281942783592498 0.395070286403518 no 1319 0.388993691569844 2023 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3035 9091303 49.47 µM 0.280558846709548 0.395603117124611 no 1320 0.389524392112906 1821 25237002
SGTC_1645 Cervolide 78 µM 0.27735762136754 0.396836370002817 no 1321 0.390752759402479 1807 23173 A fragrance.
SGTC_1382 3002-2117 298 µM 0.277106530871799 0.39693314493976 no 1322 0.390849153605706 1927 1497314
SGTC_733 4069-0007 56.1 µM 0.276400160167157 0.397205427345786 no 1323 0.391120366857266 1858 5717425 YNL287W SEC21
SGTC_1288 0973-0013 65.5 µM 0.276065581639988 0.397334413732483 no 1324 0.391248847824039 1836 4315430
SGTC_1352 1496-0991 99 µM 0.274502480706497 0.3979371674235 no 1325 0.391849248742138 1791 3000039
SGTC_435 c-PAF 6.7 µM 0.27422302162461 0.398044956493055 no 1326 0.391956618642827 1960 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_655 k060-0012 42 µM 0.271997106287722 0.398903782782391 no 1327 0.392812122172857 1805 5994525
SGTC_2273 7815444 169.05 µM 0.271192624190351 0.399214297297413 no 1328 0.393121442769764 1961 2824616
SGTC_1394 3474-0001 65.7 µM 0.270419261481043 0.399512860461713 no 1329 0.393418861697432 1809 5017666 YIL048W NEO1
SGTC_157 1348-1695 65.819 µM 0.269887208627607 0.399718298068531 no 1330 0.393623514091992 1805 5380510
SGTC_628 1636-0253 16 µM 0.269303026227638 0.399943896045261 no 1331 0.393848251793866 1930 4456143
SGTC_1649 st011737 51.3 µM 0.268127005995105 0.400398149575461 no 1332 0.394300779443861 1820 1761035
SGTC_530 4358-1714 28 µM 0.267101298731302 0.400794452763814 no 1333 0.394695583833412 1886 1564641
SGTC_3223 9129970 49.47 µM 0.266676040217809 0.400958790145817 no 1334 0.394859301586907 1840 17248386
SGTC_2254 7938975 95.19 µM 0.266024088798687 0.401210765014342 no 1335 0.39511032854108 1919 2969277
SGTC_919 tnp00227 403.569 nM 0.265915948179626 0.401252564617475 no 1336 0.395151971148067 1834 1269246 A methoxyflavone. YNL221C POP1
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.265709563502996 0.401332341641305 no 1337 0.395231448734025 1958 6708630 An antioxidant.
SGTC_120 rhodamine 6G 52.259 µM 0.265549964503531 0.401394036702689 no 1338 0.395292912405714 1840 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3060 1327-0027 12.5 µM 0.264428731991271 0.401827532876973 no 1339 0.395724787130537 1954 16000455 YPR107C YTH1
SGTC_2638 epoxomicin 18 µM 0.263151383706739 0.402321534459613 no 1340 0.396216950326988 1941 9915668 A protesome inhibitor.
SGTC_73 0327-0325 16.231 µM 0.263104541294334 0.402339653261652 no 1341 0.396235001891271 1987 53298
SGTC_2938 9059746 27.26 µM 0.262420021897653 0.402604451574551 no 1342 0.396498819086673 1866 6471769
SGTC_1670 st016595 4.04 µM 0.261581863174183 0.402928744312028 no 1343 0.396821914178752 1960 597879
SGTC_1974 st069448 26.9 µM 0.260934039339905 0.403179440180098 no 1344 0.397071687150099 1960 6323587 YNR016C ACC1
SGTC_938 3126-1755 342 µM 0.260781787481963 0.403238364619094 no 1345 0.397130395041278 1983 1777771
SGTC_2288 7946289 167.31 µM 0.260696300654598 0.403271450652102 no 1346 0.397163359545078 1943 1246052
SGTC_612 0302-0167 22.4 µM 0.260136848355906 0.403487992991765 no 1347 0.397379107602393 1928 235821
SGTC_1269 0831-0796 3.05 µM 0.2598325044865 0.403605805160397 no 1348 0.397496488438561 1929 927758
SGTC_1306 1185-0270 9.02 µM 0.259444704029237 0.403755936226912 no 1349 0.39764607066937 1940 1548076
SGTC_959 1222-0044 107 µM 0.25832133753516 0.404190910492186 no 1350 0.398079459996421 2002 6083612
SGTC_1678 st019265 80.2 µM 0.257135691820911 0.404650128150249 no 1351 0.398537012770013 2004 5367020
SGTC_803 4488-1585 147 µM 0.256735660466245 0.404805095724378 no 1352 0.398691420456674 1942 747204
SGTC_700 3453-2283 142 µM 0.255808747619866 0.405164228508988 no 1353 0.399049259489518 1912 565664
SGTC_2077 5212015 200 µM 0.255078921448663 0.40544705619666 no 1354 0.399331072017056 1898 780900
SGTC_232 clozapine 119 µM 0.254349042194016 0.405729953839158 no 1355 0.399612957515793 1888 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2788 5282734 71.43 µM 0.254129504549915 0.405815055200148 no 1356 0.399697755042654 1951 743706
SGTC_2593 nobiletin 86.24 µM 0.253881257623885 0.405911290761849 no 1357 0.399793647374411 1798 72344 An anti-infammatory.
SGTC_596 1155-0152 116 µM 0.252125587943432 0.406592056772741 no 1358 0.40047199618669 1819 280313
SGTC_872 0588-0139 234 µM 0.25162763326999 0.406785191638029 no 1359 0.400664448730819 1835 2047100
SGTC_1806 st050005 60.3 µM 0.251622183218425 0.406787305600474 no 1360 0.40066655523332 1810 5194765
SGTC_1539 benzyladenosine 56 µM 0.249723243647578 0.407524029961649 no 1361 0.401400690875461 1863 92208 A nucleotide analog.
SGTC_348 k064-0012 10.7 µM 0.248440355954775 0.408021932378065 no 1362 0.401896856284415 1822 5066323
SGTC_3052 9092717 49.47 µM 0.24729606589826 0.408466168957537 no 1363 0.402339551608006 1842 25237534
SGTC_126 0417-1624 672.48 µM 0.246283878178063 0.408859218815989 no 1364 0.402731244505687 2013 41912 YDL195W SEC31
SGTC_3177 9107506 49.47 µM 0.246022636152286 0.408960678476254 no 1365 0.402832354909873 1980 8897194
SGTC_2416 tofa 880 nM 0.246015353288118 0.408963507040162 no 1366 0.402835173742983 1732 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3355 9151058 44.0485 µM 0.245501031210083 0.409163274616603 no 1367 0.403034254905235 1967 17015728
SGTC_2540 epiandrosterone 100 µM 0.244662042978948 0.409489196221503 no 1368 0.403359060111868 1971 441302 A steroid.
SGTC_1952 st077036 64.1 µM 0.244219197833704 0.409661253435989 no 1369 0.403530529713395 2000 2937007
SGTC_1617 st002906 78 µM 0.241815310188932 0.410595530999608 no 1370 0.404461637555384 1858 5150859
SGTC_2253 7938677 135.83 µM 0.241511709946743 0.410713562277828 no 1371 0.404579270916756 1996 2301972
SGTC_2748 diazoxide 86.69 µM 0.241455215624741 0.410735526581902 no 1372 0.404601161235505 1940 3019 A potassium channel activatior.
SGTC_3193 9111931 49.47 µM 0.241042006436004 0.410896185786786 no 1373 0.404761279867253 1877 17087244
SGTC_167 3672-0051 66.205 µM 0.240839919398223 0.410974764370111 no 1374 0.404839594438132 1851 3237971
SGTC_997 3996-0078 137 µM 0.24045768518673 0.411123400308541 no 1375 0.40498773166872 1887 735687
SGTC_2850 9015429 58.44 µM 0.240115599205809 0.411256434990674 no 1376 0.405120320751006 1838 6457570
SGTC_313 3474-0040 5.03 µM 0.239884049310395 0.411346488807747 no 1377 0.405210073341296 1854 1043375 YIL048W NEO1
SGTC_528 3492-0019 172 µM 0.239808283274146 0.411375956563155 no 1378 0.405239442599749 1924 2869262
SGTC_2666 tannic acid 100 µM 0.239162791539772 0.41162702852592 no 1379 0.405489676778476 1913 16134267 A thiamine antagonist.
SGTC_2940 9060638 45.86 µM 0.238788108332679 0.411772782782321 no 1380 0.405634945854041 1878 4027022
SGTC_1720 st037298 9.481 µM 0.238151102851248 0.412020610078784 no 1381 0.405881950176192 1852 597396
SGTC_945 3381-0768 11.3 µM 0.237979906009536 0.412087220281436 no 1382 0.405948339608314 1996 1126236 YIL048W NEO1
SGTC_672 1441-0018 53.7 µM 0.236455412542516 0.412680490016371 no 1383 0.406539650987837 1851 251141
SGTC_554 4483-2211 187 µM 0.234432893770927 0.413467878323309 no 1384 0.407324462252303 1888 747107
SGTC_937 3122-0005 46.7 µM 0.234383785522834 0.413487001033967 no 1385 0.407343522689543 2005 759535
SGTC_1241 0364-0022 50.8 µM 0.233254518358111 0.413926793247526 no 1386 0.407781886811282 1911 4563895
SGTC_1063 disulfiram 1.84 µM 0.231816159329411 0.41448711732777 no 1387 0.408340402786962 1905 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_341 1486-1430 230 µM 0.23108531363831 0.414771890782235 no 1388 0.408624262193619 1848 2054753 YPL210C SRP72
SGTC_2015 5119600 184 µM 0.229860394800518 0.415249279837605 no 1389 0.409100126339296 1984 2828786
SGTC_778 3456-2434 196 µM 0.226995203882519 0.416366421608958 no 1390 0.410213735791824 2034 5539063
SGTC_697 0508-1955 564 µM 0.226099492666176 0.416715799719366 no 1391 0.410562019584075 2029 6243113
SGTC_45 0kpi-0036 14.9 µM 0.225461737774713 0.416964600369912 no 1392 0.410810043960774 1926 2795021
SGTC_1588 farnesol 29.9 µM 0.22463635368784 0.417286648200657 no 1393 0.411131090707577 1873 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2225 6654152 15.4 µM 0.223384816910429 0.41777507782377 no 1394 0.411618010070786 1987 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_89 0302-0250 142.109 µM 0.222245610350202 0.418219779340033 no 1395 0.412061344943559 2024 4203518 YLR208W SEC13
SGTC_550 4123-0385 25.7 µM 0.221796829842291 0.418394994372768 no 1396 0.412236023710463 1895 5731123
SGTC_3087 9117406 49.47 µM 0.221608532456726 0.418468515163514 no 1397 0.412309319852657 1905 42546093
SGTC_1626 st003712 1.76 µM 0.220495813813038 0.418903034676641 no 1398 0.412742516126875 1948 24207035
SGTC_1564 D-Arginine 115 µM 0.220163049042348 0.419032999426051 no 1399 0.412872086580841 1814 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_105 0111-0055 734.78 µM 0.219484602855674 0.419298001012449 no 1400 0.413136286306908 1938 5179370
SGTC_1902 st060212 70.5 µM 0.218629565625621 0.419632031324532 no 1401 0.41346930993631 2030 688944
SGTC_457 grayanotoxin iii 135 µM 0.218524412567788 0.419673114602721 no 1402 0.413510269711765 1952 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2365 9042475 200 µM 0.216872751254231 0.420318532940074 no 1403 0.41415375678543 1902 6464479
SGTC_1316 1272-0050 65.9 µM 0.216469300530703 0.4204762216831 no 1404 0.414310976243474 1925 7340392
SGTC_1805 st050013 60.3 µM 0.215653369827294 0.420795167236372 no 1405 0.414628975682636 1991 4037144
SGTC_165 k038-0023 64.381 µM 0.215104915065743 0.421009586256638 no 1406 0.414842760966947 1911 46368543
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.212776028433077 0.421920327425711 no 1407 0.415750831069182 1913 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3280 9140961 49.47 µM 0.212645514649599 0.421971378931176 no 1408 0.415801733840666 1880 4901226
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.211995598960701 0.422225618132467 no 1409 0.416055233907241 1878 688664
SGTC_1786 berberine 21.6 µM 0.211683440124349 0.422347742443633 no 1410 0.416177004102258 1897 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1096 rimcazole 32.2 µM 0.211473004874379 0.422430074167847 no 1411 0.416259097434463 1911 18528119 A dopamine reuptake inhibitor.
SGTC_2358 9037157 4 µM 0.211072009390121 0.422586970996899 no 1412 0.41641554072606 1934 2388925
SGTC_2301 7769476 200 µM 0.210062386665639 0.422982058722642 no 1413 0.416809490787519 1949 977820
SGTC_2265 7929201 200 µM 0.206983893443451 0.42418721792103 no 1414 0.418011218645516 1898 1265108
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.206823308346997 0.424250102848827 no 1415 0.41807392613649 1946 2333 A French combination drug.
SGTC_15 0266-0086 27.098 µM 0.206787694691137 0.424264049374331 no 1416 0.418087833331946 2068 1712902 YIL048W NEO1
SGTC_2670 beta-carotene 100 µM 0.206492085436366 0.424379815425875 no 1417 0.41820327321925 2012 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1396 3511-0007 98.6 µM 0.205424408519637 0.424797991718876 no 1418 0.418620275830134 1936 X1396
SGTC_1143 3454-2408 5.08 µM 0.204579191343107 0.425129097409502 no 1419 0.418950457222497 1977 X1143
SGTC_2056 5235370 200 µM 0.203041398691832 0.425731648191075 no 1420 0.419551337301008 1915 5511916
SGTC_2224 6650123 117.647 µM 0.201178574189795 0.426461787893695 no 1421 0.42027947215436 1959 2908370
SGTC_2796 7949634 45.45 µM 0.200631377735893 0.426676311215699 no 1422 0.420493410514325 1920 2971588
SGTC_396 dithiazanine 1.25 µM 0.200059665677825 0.426900468824944 no 1423 0.420716958872727 1896 10578 An antihelmenthic.
SGTC_1795 st049545 62.3 µM 0.199935067404219 0.426949324614291 no 1424 0.420765682142934 2104 5291882
SGTC_765 1319-0117 244 µM 0.199451528968671 0.427138933770116 no 1425 0.420954777903596 1996 3487746 YGL099W LSG1
SGTC_2886 9058944 51.95 µM 0.198593222115095 0.42747554170261 no 1426 0.421290477988897 2001 4949929
SGTC_175 3793-3120 23.7 µM 0.1983799137464 0.427559204471696 no 1427 0.421373915824037 1926 5322297
SGTC_2442 5158906 48.48 µM 0.197656430626446 0.427842989735694 no 1428 0.421656940209682 2041 1893835
SGTC_1975 st070967 30.8 µM 0.196883713291217 0.428146128277473 no 1429 0.421959269567388 2087 261391
SGTC_944 3370-0224 231 µM 0.19678610956513 0.428184421432988 no 1430 0.421997460768246 1909 4580514
SGTC_193 1273-0060 1.558 µM 0.196037010965236 0.428478339966067 no 1431 0.422290598716307 2055 2847393 YHR072W ERG7
SGTC_1663 st014140 55.4 µM 0.195947352763065 0.428513521184071 no 1432 0.422325686733641 2061 4207120
SGTC_1455 4262-0120 131 µM 0.195543391734517 0.428672039557714 no 1433 0.422483785785041 2032 1529587
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.195328590946527 0.428756334236886 no 1434 0.422567857895018 1952 5379071
SGTC_989 1501-0895 10.3 µM 0.194124538363748 0.429228902926676 no 1435 0.423039184126223 2077 2830112
SGTC_451 chloral hydrate 100 µM 0.193782875618498 0.42936301783335 no 1436 0.423172948061242 1969 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1218 1348-1416 30.7 µM 0.193655411896756 0.42941305401431 no 1437 0.423222853485608 1944 6787668
SGTC_2038 4100038 30.985 µM 0.192639718237755 0.429811807384544 no 1438 0.423620568418805 1983 3596803
SGTC_497 capsazepine 133 µM 0.192152260843349 0.430003204792879 no 1439 0.423811469661313 1861 2733484 A calcium channel blocker.
SGTC_68 0986-0284 82.829 µM 0.19167056601784 0.43019235572062 no 1440 0.424000131695153 1771 423278 YIL048W NEO1
SGTC_3012 9080433 71.4286 µM 0.191269565930057 0.430349831827431 no 1441 0.42415720187541 2095 17688859
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.19031985349493 0.430722836031502 no 1442 0.424529248566046 2032 16486 A toxic proline analog.
SGTC_2269 7935389 174.42 µM 0.189857020997641 0.430904638181283 no 1443 0.424710586052819 1883 97605
SGTC_708 3448-5400 146 µM 0.188735571794169 0.43134520782194 no 1444 0.425150035168162 2082 3462195
SGTC_1325 1431-0015 227 µM 0.188682085210791 0.431366222561816 no 1445 0.425170996655132 1880 1103340
SGTC_1088 bifonazole 369 nM 0.188435047647486 0.431463285499593 no 1446 0.425267813858679 2063 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2873 9040596 71.43 µM 0.187542613898602 0.431813963947228 no 1447 0.425617607650451 1908 6463863
SGTC_1949 st076024 69.1 µM 0.186859603971521 0.432082386418073 no 1448 0.425885356313072 1887 2921930
SGTC_1492 4158-0558 28.5 µM 0.186634462967986 0.432170873567962 no 1449 0.425973621972658 2074 3967268
SGTC_291 SEC14.278 35.5 µM 0.18461649915152 0.432964145133193 no 1450 0.42676492197353 2063 1068044
SGTC_2268 7933382 153.85 µM 0.184580830654881 0.432978169035425 no 1451 0.42677891124882 2103 935025 YOR257W CDC31
SGTC_2233 sulbentine 40.3845 µM 0.184149905307398 0.433147604061815 no 1452 0.426947928541336 2035 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1499 4480-0877 67.3 µM 0.184059992472375 0.433182958333449 no 1453 0.426983195794172 2078 2861909
SGTC_1475 4092-1048 11.7 µM 0.181972071032748 0.434004091508296 no 1454 0.427802322009372 1996 2881759
SGTC_177 1327-0068 8.361 µM 0.181960907305679 0.434008482723231 no 1455 0.427806702564391 2078 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2043 5101342 149 µM 0.180623101488515 0.434534763004703 no 1456 0.428331710879215 1993 678451
SGTC_1513 0337-0559 19 µM 0.178354394517204 0.435427515834632 no 1457 0.429222331446121 1918 775073
SGTC_793 0488-0545 106 µM 0.177912412524553 0.435601477446974 no 1458 0.429395881290363 1920 292548
SGTC_2826 7992541 19.48 µM 0.177344283581241 0.435825108086301 no 1459 0.429618984378791 2096 2985066
SGTC_2101 5377231 179.231 µM 0.177119417914692 0.435913626856639 no 1460 0.429707294885264 2042 2844213
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.176264960779287 0.43625001467078 no 1461 0.430042894125391 1947 442882
SGTC_1992 st073643 23.3 µM 0.173384461517579 0.437384365296823 no 1462 0.431174619021618 2007 3161292
SGTC_3231 9132313 49.47 µM 0.173102425915743 0.437495459722752 no 1463 0.43128545906693 2011 4905967
SGTC_923 1900-2434 73.3 µM 0.172227995234782 0.437839931121346 no 1464 0.431629144851387 1975 5910570
SGTC_3220 9131269 49.47 µM 0.171929286326176 0.437957614694553 no 1465 0.43174656112132 2098 17722206
SGTC_1652 st011932 78 µM 0.171906126526191 0.437966739285249 no 1466 0.43175566500986 2082 1551076
SGTC_2684 capsaicin 100 µM 0.17087937994982 0.438371294085457 no 1467 0.432159305297668 2032 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2058 5236698 133 µM 0.16984164051504 0.438780245696065 no 1468 0.43256733912353 1993 766665
SGTC_487 nimodipine 119 µM 0.169525227388385 0.438904950577188 no 1469 0.432691765470648 2115 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3222 9128301 49.47 µM 0.169405765863759 0.438952034383778 no 1470 0.432738744275472 2010 4911358
SGTC_2308 7584454 197.62 µM 0.168953036327204 0.439130478162587 no 1471 0.432916790912412 2081 893577
SGTC_2900 5328528 85.29 µM 0.168448698037935 0.439329278145587 no 1472 0.433115149951432 2049 795359
SGTC_1930 st074634 34.3 µM 0.168003354978152 0.439504836122855 no 1473 0.433290319852605 1999 684253 YOR116C RPO31
SGTC_2959 9079155 11 µM 0.167288268492032 0.43978675410223 no 1474 0.4335716172271 2022 16189457
SGTC_3335 9143315 29.6265 µM 0.167249636742832 0.439801985277029 no 1475 0.433586814963139 1972 4899691
SGTC_2514 salinomycin 42.74 µM 0.167064387455412 0.439875023960191 no 1476 0.433659693425146 2133 23682228 A polyether potassium ionophore.
SGTC_746 1095-0025 46.6 µM 0.165079642207192 0.440657682166252 no 1477 0.43444064816497 2082 6749286
SGTC_1486 3970-0793 4.53 µM 0.164748586984246 0.440788252089058 no 1478 0.434570936287856 2134 2844330
SGTC_2685 mycophenolic acid 18.85 µM 0.163930661341397 0.441110873839585 no 1479 0.434892864673168 2080 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1159 4092-0538 61.2 µM 0.163798027205993 0.441163193600141 no 1480 0.434945072382924 2048 717301
SGTC_180 1486-1293 102.781 µM 0.163552643088655 0.441259992189806 no 1481 0.435041663952442 2152 4140536
SGTC_2654 protoveratrine a 100 µM 0.163480506962911 0.441288448958503 no 1482 0.435070059932866 2075 5702278 A heart drug and vasodilator.
SGTC_679 0422-0091 41.4 µM 0.163275385308505 0.441369368454274 no 1483 0.435150806748601 1986 627384 YHR062C RPP1
SGTC_1216 1165-0504 9.65 µM 0.159218208071294 0.442970403834972 no 1484 0.436748479442591 2138 6304004
SGTC_2673 kobusone 100 µM 0.158187296833961 0.443377369495065 no 1485 0.437154606690244 2083 6710676 An epoxy ketone and protein crosslinker.
SGTC_502 l-744,832 89.3 µM 0.156882488418896 0.443892545232907 no 1486 0.437668730585117 2129 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_906 1165-0455 526 µM 0.154365784412964 0.44488647916666 no 1487 0.438660665171159 2077 3252859
SGTC_2290 7904846 200 µM 0.154329756807411 0.444900710252301 no 1488 0.438674867917002 1990 2962154
SGTC_500 h-89 112 µM 0.152913632172627 0.445460142688597 no 1489 0.439233192711476 2147 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_427 1354-0053 47.3 µM 0.15212398165898 0.445772137127804 no 1490 0.439544574852755 2095 6813657
SGTC_2275 7947463 200 µM 0.151439486622486 0.446042611348748 no 1491 0.439814521407422 2143 1225414
SGTC_1082 camptothecin 424.86 nM 0.1505640307216 0.446388579219764 no 1492 0.440159818591818 1953 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3261 9137475 49.47 µM 0.149491259992472 0.44681257876196 no 1493 0.4405830026964 2157 17027690
SGTC_2876 9059903 25.97 µM 0.148840184926174 0.447069937920234 no 1494 0.440839870401939 2146 6916095
SGTC_1987 st072290 61.9 µM 0.146322762743002 0.448065241848485 no 1495 0.441833298588933 2038 54697379
SGTC_37 0566-0070 1.56 µM 0.14621814953343 0.448106609508318 no 1496 0.441874589143605 2117 1626686
SGTC_2428 5615643 7.78 µM 0.145913401211701 0.448227120687397 no 1497 0.441994876091278 2097 2253075
SGTC_3290 9121031 71.43 µM 0.145399126267809 0.44843049893658 no 1498 0.442197877235413 2017 17014854
SGTC_2310 7668677 200 µM 0.145054679869982 0.448566723354402 no 1499 0.442333849988335 2088 2197143
SGTC_199 4063-0024 41.6 µM 0.144668586293263 0.448719425939709 no 1500 0.442486271346849 2133 306215
SGTC_2156 5649887 115 µM 0.144291812943777 0.448868449637506 no 1501 0.442635021490274 2137 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3245 9134821 49.47 µM 0.144271276482212 0.448876572551802 no 1502 0.442643129519263 2027 17014901
SGTC_2325 6158266 200 µM 0.144263012940004 0.448879841088063 no 1503 0.442646392066647 2039 3623240
SGTC_1977 st070720 65.3 µM 0.14403876729279 0.448968539850664 no 1504 0.442734928470952 2006 682188
SGTC_3055 9094636 49.47 µM 0.144038622478889 0.448968597131592 no 1505 0.442734985647132 2111 25236176
SGTC_2961 9083290 32.55 µM 0.143765034290092 0.449076816439407 no 1506 0.442843007290743 2159 17741490
SGTC_1246 0422-0085 105 µM 0.143634116711591 0.449128602945897 no 1507 0.442894699373702 2154 264295
SGTC_2064 5220758 200 µM 0.143440986047519 0.44920500039846 no 1508 0.442970957724389 2063 788518
SGTC_2082 5219693 150 µM 0.142306511953338 0.449653806684047 no 1509 0.44341895154076 2110 2834649
SGTC_2534 helenine 20.12 µM 0.141916243699626 0.449808214591114 no 1510 0.443573081782632 2065 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3199 9111318 49.47 µM 0.140447548474211 0.45038936527715 no 1511 0.444153195935045 2107 8548020
SGTC_1232 0279-0259 161 µM 0.139761047261537 0.450661044753839 no 1512 0.444424395467498 2015 1560000
SGTC_1285 0929-0069 65.5 µM 0.139621249264208 0.450716371960768 no 1513 0.444479625295074 2044 1206237
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.139205127008537 0.450881064405183 no 1514 0.444644028592888 2124 5282309
SGTC_671 0560-0003 407 µM 0.138427993103062 0.451188660297259 no 1515 0.444951087342312 2113 3238678
SGTC_2858 9025781 8.96 µM 0.137339248474393 0.45161964349537 no 1516 0.445381324276455 2160 4894980 YPL153C RAD53
SGTC_2978 9011784 42.97 µM 0.137264634626457 0.451649181730158 no 1517 0.445410811635783 2171 2994934
SGTC_969 1313-0238 134 µM 0.134499828776766 0.452743904312027 no 1518 0.446503673237878 2063 5212874
SGTC_2634 4'-methoxyflavone 100 µM 0.132802746666176 0.453416041055016 no 1519 0.447174691038675 2038 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1036 k216-0215 33.5 µM 0.131252775620395 0.454030030486338 no 1520 0.447787674057121 2148 622330
SGTC_1001 4048-4355 44.4 µM 0.127518600820473 0.455509696138664 no 1521 0.449264976017629 2124 21824233
SGTC_2213 7173844 200 µM 0.12580055119317 0.45619068139951 no 1522 0.449944902725952 2161 892728
SGTC_3107 9121808 49.47 µM 0.123034220575973 0.457287444592332 no 1523 0.451039999858668 2190 662681
SGTC_1287 0971-0001 34.6 µM 0.122614461493576 0.457453894521991 no 1524 0.45120620112198 2109 4665869
SGTC_252 miconazole 1.30953 nM 0.122167591867227 0.457631102981631 no 1525 0.451383146053944 2181 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_363 0455-0021 3.06 µM 0.122111973045382 0.457653159503026 no 1526 0.451405169862379 2135 4597466
SGTC_1955 wogonin 32.4 µM 0.121203741034567 0.458013351642631 no 1527 0.451764830524006 2159 5281703 A flavanone.
SGTC_533 1222-0222 6.71 µM 0.12105807950755 0.458071122187706 no 1528 0.451822516306508 2185 3982874
SGTC_904 1141-0088 396 µM 0.120883054560143 0.45814053967538 no 1529 0.45189183211846 2014 1378119
SGTC_807 1315-0151 48 µM 0.119759152101154 0.458586326377144 no 1530 0.452336970443835 2218 4011080
SGTC_2391 6285546 200 µM 0.117960861427131 0.459299711760221 no 1531 0.453049334681609 2118 846083
SGTC_3129 9127257 49.47 µM 0.117219460225154 0.459593865339375 no 1532 0.453343073098608 1970 837894
SGTC_613 3914-0030 117 µM 0.117060502476739 0.459656935279872 no 1533 0.453406054471344 2172 1145395
SGTC_1353 1498-1206 8.11 µM 0.116778590141792 0.459768792620024 no 1534 0.453517755121543 2174 6756808
SGTC_2785 7756463 72.73 µM 0.116715242333923 0.459793928238556 no 1535 0.453542855598496 2142 2201551
SGTC_2019 4016004 108 µM 0.11523739468513 0.460380365110267 no 1536 0.454128479712852 2103 45595336
SGTC_191 3914-0123 66.505 µM 0.114765664790654 0.46056757433437 no 1537 0.454315432357207 2084 3144412
SGTC_1818 st052136 56.3 µM 0.113287021479612 0.461154440459491 no 1538 0.454901503178683 2125 674169
SGTC_1808 st050063 61.5 µM 0.112410143131153 0.461502509131469 no 1539 0.455249106623412 2199 4011993
SGTC_1460 k062-0059 9.15 µM 0.111814819102783 0.461738834268653 no 1540 0.455485118632763 2176 1373085
SGTC_712 r015-0009 80.6 µM 0.111303844170779 0.461941686213486 no 1541 0.455687703570875 2162 6813872 YLR060W FRS1
SGTC_1749 st037932 54.2 µM 0.111223321612236 0.461973653769392 no 1542 0.455719629198133 2115 594497
SGTC_3264 9137442 49.47 µM 0.111115942641375 0.462016283736577 no 1543 0.455762203315013 2211 17015726
SGTC_1634 st006576 41 µM 0.110405248767137 0.462298443596658 no 1544 0.456043995332358 2205 3915356
SGTC_2987 9018338 71.43 µM 0.11036826439323 0.462313127662663 no 1545 0.456058660341787 2231 5055682
SGTC_2652 actinonin 100 µM 0.108007692055216 0.46325046131153 no 1546 0.456994795264994 2226 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1988 st071872 53.4 µM 0.106812084893698 0.463725289959762 no 1547 0.457469029983635 2233 16414116
SGTC_976 1348-1067 47.6 µM 0.106658884422256 0.463786136413156 no 1548 0.457529800975557 2203 5310671 YGL099W LSG1
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.105135702340051 0.464391142721451 no 1549 0.458134064954416 2123 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2952 9073731 13.78 µM 0.103460007089645 0.465056822168439 no 1550 0.458798944415587 2137 16457353
SGTC_296 1222-0039 74.9 µM 0.103003526821412 0.465238178573938 no 1551 0.458980085922946 2134 5984176
SGTC_3105 9121040 49.47 µM 0.102505784876719 0.465435936181531 no 1552 0.459177610685462 2228 41448907
SGTC_654 1124-0271 80.9 µM 0.102316700990988 0.465511063247274 no 1553 0.459252649701373 2100 5403748
SGTC_2161 5662504 8.5105 µM 0.0994797201415221 0.466638402408854 no 1554 0.460378694501547 2126 2859334
SGTC_1100 amiodarone 5.07 µM 0.0985919276659484 0.46699124245429 no 1555 0.460731139791384 2261 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3146 9095609 49.47 µM 0.0977847345010025 0.467312072012998 no 1556 0.461051614694256 2162 17173999
SGTC_3224 9130643 49.47 µM 0.0962910000199607 0.467905832320635 no 1557 0.461644729408289 2186 17644395
SGTC_1423 4048-0112 5.59 µM 0.0961176935319141 0.467974726396711 no 1558 0.461713549481326 2243 X1423
SGTC_433 pimozide 108 µM 0.0945713127354628 0.468589497344099 no 1559 0.462327668401534 2193 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2549 cedrol 20.94 µM 0.0942247450645729 0.468727287276286 no 1560 0.462465314249283 2252 6708665 A sedative which affects the nervous system.
SGTC_1660 st012960 28.1 µM 0.0924307012702173 0.469440630793176 no 1561 0.463177923871314 2154 24207266
SGTC_1146 3579-1023 7 µM 0.0901503149327833 0.470347494002103 no 1562 0.464083883212112 2241 X1146
SGTC_3030 9087619 49.47 µM 0.0899076779008927 0.470443994944673 no 1563 0.464180289891262 2205 25236973
SGTC_2393 9031399 185.94 µM 0.0896092642446367 0.470562681594623 no 1564 0.464298861112574 2218 1526623 YDL150W RPC53
SGTC_1411 3909-8223 150 µM 0.0890845612899232 0.470771375550196 no 1565 0.464507353456738 2272 X1411
SGTC_1123 mangostin 811.285 nM 0.0888938281638274 0.470847239228119 no 1566 0.464583144273341 2100 5281650 An antioxidant.
SGTC_3058 9093861 49.47 µM 0.0881962948942701 0.471124690528154 no 1567 0.464860331044634 2216 17217477
SGTC_101 0490-5701 117.494 µM 0.0881099000122912 0.471159055992443 no 1568 0.464894663956368 2241 4661669
SGTC_2803 7707263 71.43 µM 0.0877385773118265 0.471306760204521 no 1569 0.46504222878898 2173 2199229
SGTC_409 arachidonic acid 100 µM 0.0869607076574284 0.471616192852336 no 1570 0.465351372246371 2262 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1773 st048542 73.5835 µM 0.086813292262131 0.471674835894324 no 1571 0.465409960909185 2128 3237138
SGTC_526 4469-0568 170 µM 0.0867822759708038 0.47168717450526 no 1572 0.465422288095985 2221 2901964
SGTC_220 paclitaxel 373.376 µM 0.0863572783406728 0.471856245819888 no 1573 0.465591203477581 2239 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1377 2944-0135 198 µM 0.0855998780901027 0.472157565126636 no 1574 0.465892247687692 2200 1894137
SGTC_1198 1612-1005 86.7 µM 0.0846780798780361 0.472524308957547 no 1575 0.466258661543975 2233 6998509
SGTC_882 0843-0131 351 µM 0.0846658612520368 0.472529170380016 no 1576 0.4662635186282 2276 5425421
SGTC_866 0495-0101 262 µM 0.0839673647757143 0.472807087825105 no 1577 0.466541189621377 2054 635694
SGTC_1623 st003709 20.3 µM 0.0830852825698826 0.473158069170672 no 1578 0.466891864094725 2226 16192618
SGTC_2505 galangin 7.89 µM 0.0830144988953659 0.473186234968716 no 1579 0.466920005478148 2120 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2833 9001315 45.46 µM 0.0803013310423588 0.474265941522355 no 1580 0.467998799807936 2105 2989378
SGTC_1863 st057641 20.1 µM 0.0801908551466205 0.474309909521613 no 1581 0.468042731637642 2284 3921635
SGTC_258 haloperidol 50.781 µM 0.0781793733311184 0.475110507841859 no 1582 0.468842684744233 2131 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_747 3448-8087 38.7 µM 0.0774969661340196 0.475382138589359 no 1583 0.469114102345811 2196 5168703
SGTC_2922 7999257 32.47 µM 0.0769007541097051 0.475619468899804 no 1584 0.469351248816344 2275 2988377
SGTC_1162 k048-0130 20.1 µM 0.0765993796776348 0.475739438390712 no 1585 0.469471126225315 2139 6797406
SGTC_1741 st038134 10.228 µM 0.0758512486080758 0.47603725981163 no 1586 0.469768721517528 2235 1272587
SGTC_1732 st034308 51.822 µM 0.0756939996439542 0.476099860323501 no 1587 0.469831274944841 2171 830119
SGTC_3327 9140648 26.9345 µM 0.0753393141184987 0.476241062116334 no 1588 0.469972371103176 2257 8029710
SGTC_2662 daunorubicin 22.37 µM 0.0744237691754948 0.476605558138817 no 1589 0.470336598090031 2242 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3296 9122258 64.045 µM 0.0719952187730246 0.477572504703542 no 1590 0.471302856422623 2223 4730474
SGTC_2446 5162541 200 µM 0.0714852778901884 0.477775558667244 no 1591 0.471505770561301 2263 1549321
SGTC_2733 amorolfine 100 µM 0.0714261522113531 0.477799102365546 no 1592 0.471529298152715 2294 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1960 st011366 51.8 µM 0.0713943270322993 0.477811775104797 no 1593 0.471541962231278 2281 3972846
SGTC_1478 0453-0656 35.7 µM 0.0713711168542398 0.477821017377537 no 1594 0.471551198191755 2267 5258496
SGTC_1501 4491-0275 38.4 µM 0.0708309947890889 0.478036096872823 no 1595 0.471766131747049 2291 5104718
SGTC_1020 4335-0961 93.3 µM 0.0706669724132322 0.478101412729346 no 1596 0.471831403646457 2098 669075
SGTC_3305 9127027 53.8275 µM 0.0702857770391238 0.478253211984706 no 1597 0.471983101393933 2204 41905295
SGTC_1610 st001799 48.1 µM 0.0686325137844024 0.478911609118644 no 1598 0.472641068810309 2201 621897
SGTC_583 1488-1091 88.9 µM 0.0653495538795945 0.480219187057835 no 1599 0.473947844171029 2300 4303273
SGTC_3269 9137823 49.47 µM 0.0643515790372745 0.480616715679669 no 1600 0.474345142197471 2196 17682936
SGTC_1050 3232-1156 69.3 µM 0.0642748941674222 0.480647262773935 no 1601 0.474375671830763 2208 700529
SGTC_392 N-ethylmaleimide 8.33 µM 0.0636099409341333 0.48091214883403 no 1602 0.474640408027028 2243 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_755 1995-0008 37.3 µM 0.0630029683342944 0.481153945500478 no 1603 0.474882070315088 2294 689533
SGTC_488 nitrendipine 139 µM 0.0625742156199152 0.481324749778372 no 1604 0.475052781061861 2304 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_136 0097-0015 404.482 µM 0.0622399528940677 0.481457914005636 no 1605 0.475185873169635 2301 4861337
SGTC_1771 st048882 4.1505 µM 0.0616370000998899 0.481698124720705 no 1606 0.475425955563689 2247 4580403
SGTC_1843 st055809 45.5 µM 0.0614966541792416 0.481754038170362 no 1607 0.475481839471588 2216 16413835
SGTC_1053 3366-3204 134 µM 0.0613563414643535 0.481809938749715 no 1608 0.475537710639541 2227 3632071 YPR165W RHO1
SGTC_2457 5731572 11.68 µM 0.0604644021771554 0.482165295638868 no 1609 0.475892883450924 2311 2865357
SGTC_3353 9151644 39.2805 µM 0.0599609248994851 0.482365891933437 no 1610 0.476093378039398 2248 4909158
SGTC_585 0kpi-0023 191 µM 0.0590264976872408 0.482738199845288 no 1611 0.476465501400082 2289 64601
SGTC_1037 k284-1091 78.7 µM 0.0577604711732103 0.483242652266799 no 1612 0.476969712508542 2295 3334711
SGTC_2570 licareol 100 µM 0.0574592498537488 0.483362678871415 no 1613 0.477089683177815 2199 443158
SGTC_2751 anetholtrithion 17.25 µM 0.0565051567143707 0.483742862923723 no 1614 0.477469693813245 2274 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1497 4476-2978 41.3 µM 0.0557281056276128 0.484052510749468 no 1615 0.477779204617575 2264 1528379
SGTC_1338 1486-1223 76 µM 0.0552234238743539 0.484253627024376 no 1616 0.477980233926913 2259 3444526
SGTC_2852 9023854 51.95 µM 0.055032056820886 0.484329888071537 no 1617 0.47805646241568 2289 19798528
SGTC_2830 7992007 71.43 µM 0.0540703014554791 0.484713162621885 no 1618 0.478439576813425 2307 1952075
SGTC_542 3381-0244 89.3 µM 0.0536694261245472 0.484872921899823 no 1619 0.478599271049528 2312 1112843
SGTC_78 0336-0123 156.75 µM 0.05170030515338 0.485657702753022 no 1620 0.479383747044666 2154 6765896
SGTC_223 busulfan 5 mM 0.0511869002693845 0.48586232631321 no 1621 0.479588295115926 2290 2478 A DNA alkylator.
SGTC_117 lucigenin 22.078 µM 0.0504961178880965 0.486137651627096 no 1622 0.479863521468285 2174 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1788 fluconazole 20 µM 0.0504690750383526 0.486148430238035 no 1623 0.479874296265933 2186 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3117 9124945 49.47 µM 0.0497363477609204 0.486440481030652 no 1624 0.480166245482933 2282 17592065
SGTC_1906 st060206 94.7 µM 0.0483261839993715 0.487002565115386 no 1625 0.480728143557346 2308 5133468
SGTC_717 1532-0246 73.2 µM 0.0478122540766564 0.487207421440662 no 1626 0.480932935192824 2270 9561992
SGTC_1013 4112-3890 241 µM 0.0471674269389846 0.48746445914661 no 1627 0.48118989407596 2234 705171
SGTC_2956 9076196 2.52 µM 0.0469270813536508 0.487560265816302 no 1628 0.481285672033371 2333 16423868
SGTC_2783 7738165 71.43 µM 0.0464683624435882 0.487743122550877 no 1629 0.481468474974008 2262 17201110
SGTC_1779 st039427 55 µM 0.0449551859417913 0.488346330294036 no 1630 0.4820715146259 2342 1124498
SGTC_3009 9080819 71.4286 µM 0.0437378191551328 0.488831636833851 no 1631 0.482556696361107 2273 17027216
SGTC_413 propylparaben 100 µM 0.0435190423202658 0.488918854580558 no 1632 0.482643892664368 2301 7175 A pharmaceutical preservative.
SGTC_3216 9129716 49.47 µM 0.0428786009989344 0.489174176457007 no 1633 0.482899153494061 2303 8056934
SGTC_2805 7950783 58.44 µM 0.0412513580627833 0.489822921833463 no 1634 0.483547755338037 2301 1178958 YDL195W SEC31
SGTC_1796 st049173 110.4 µM 0.0405796329955025 0.490090731548575 no 1635 0.483815510647719 2329 94134
SGTC_2863 9028737 58.44 µM 0.0392118217353875 0.490636077184653 no 1636 0.484360754252118 2346 6460917
SGTC_2345 9052315 157.45 µM 0.0390635825380608 0.490695181144864 no 1637 0.484419847859551 2287 6469265
SGTC_2921 7974240 10.71 µM 0.038756621674727 0.490817569143788 no 1638 0.484542214859236 2306 2979074 YDR527W RBA50
SGTC_1635 st007035 42.4 µM 0.0385470430028729 0.490901130502866 no 1639 0.484625762220661 2341 3716403
SGTC_2476 5806916 10.51 µM 0.0381581741537652 0.491056177914778 no 1640 0.484780784390383 2304 2870194
SGTC_1932 st074806 40.9 µM 0.0374692910071343 0.491330848497311 no 1641 0.485055412585742 2289 17251235
SGTC_1873 rapamycin 2 nM 0.0365523104974034 0.491696472116089 no 1642 0.485420984402794 2330 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_465 cgp-37157 41 µM 0.0362923983787317 0.491800107018094 no 1643 0.485524605581728 2338 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_86 0417-1630 471.922 µM 0.0360839498196016 0.491883222227 no 1644 0.485607710091119 2338 3634867
SGTC_1547 harmine 94.2 µM 0.0360359259993139 0.491902370933574 no 1645 0.485626856371311 2335 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0359221768624062 0.491947726600908 no 1646 0.485672206349262 2344 803109
SGTC_2035 5154463 94.595 µM 0.0350373788072439 0.492300529325437 no 1647 0.486024967591188 2336 2769623
SGTC_1408 3909-7976 48.8 µM 0.0347095921404896 0.492431231912625 no 1648 0.486155656057715 2322 24152374
SGTC_3262 9137218 49.47 µM 0.0320275263178048 0.493500715727204 no 1649 0.487225049663195 2350 17650664
SGTC_1840 st055363 71 µM 0.0314385101514999 0.493735594658929 no 1650 0.487459914829821 2242 676033
SGTC_1389 3405-0187 19 µM 0.0311617475563185 0.493845958603243 no 1651 0.487570273058206 2319 799890
SGTC_1481 3346-2004 36 µM 0.029934514897095 0.49433534473312 no 1652 0.4880596396343 2355 2770522
SGTC_3270 9137563 49.47 µM 0.0289298749036753 0.494735973500317 no 1653 0.488460259430563 2333 17015724
SGTC_518 1021-0119 62.6 µM 0.0288450770655174 0.494769789298378 no 1654 0.488494074761322 2236 1097762
SGTC_2352 9027995 87.8 µM 0.0266429489038784 0.495647969435955 no 1655 0.489372258567118 2316 2997347
SGTC_2629 bisabolol 100 µM 0.0258551307278857 0.495962146445841 no 1656 0.489686444281143 2324 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_668 1682-0499 62.6 µM 0.0258387592866035 0.495968675302479 no 1657 0.489692973359974 2332 682214
SGTC_297 0986-0032 24 µM 0.025600774653631 0.496063582617328 no 1658 0.489787884094707 2353 2847425
SGTC_2083 5306046 65.942 µM 0.0254105191398991 0.496139455911824 no 1659 0.489863760378882 2347 539837
SGTC_2879 9041815 71.43 µM 0.0245328048257816 0.496489487357457 no 1660 0.490213808558442 2361 4942971
SGTC_489 paxilline 115 µM 0.0243925027805313 0.496545439907136 no 1661 0.490269764231232 2272 105008 A toxic potassium channel blocker.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.023870312269979 0.496753690421106 no 1662 0.490478027454698 2310 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1856 st057054 55.7 µM 0.0234601976310973 0.496917245499112 no 1663 0.490641593714225 2366 1266018
SGTC_361 000s-0510 1.45 µM 0.0231545631095153 0.497039133898349 no 1664 0.490763491132853 2330 660
SGTC_764 1951-2361 146 µM 0.0226552865892743 0.497238248172651 no 1665 0.490962621402057 2359 5438930
SGTC_573 3702-0553 84.7 µM 0.02177174343613 0.497590611788497 no 1666 0.491315017157095 2361 1222756
SGTC_2799 7812892 81.82 µM 0.0208288904126459 0.497966630690489 no 1667 0.491691075759212 2353 20205235
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0205196834757715 0.498089945816211 no 1668 0.491814405119321 2360 4330530
SGTC_799 1310-0557 151 µM 0.0199570301639889 0.498314338602469 no 1669 0.49203882534667 2304 5354492
SGTC_2114 5491910 81.25 µM 0.019917700908249 0.498330023594942 no 1670 0.492054512331554 2357 2849228
SGTC_1178 0988-0033 191 µM 0.0183898804259606 0.498939339016284 no 1671 0.492663912664641 2350 5392207
SGTC_2705 st078069 42.8 µM 0.018165669343316 0.499028757663258 no 1672 0.492753345005161 2355 1530061
SGTC_953 1188-0045 9.7 µM 0.0180962433155371 0.499056445784919 no 1673 0.492781037430935 2350 6144426
SGTC_1800 st050079 29.0735 µM 0.0178373400856749 0.499159700242425 no 1674 0.492884308206034 2358 3645560
SGTC_1950 st077106 7.18 µM 0.0171870657335846 0.499419039555347 no 1675 0.493143690358022 2318 13831864
SGTC_2018 5133068 143 µM 0.0168293849012355 0.49956168822913 no 1676 0.493286363726425 2374 785362
SGTC_1658 st012944 20 µM 0.0165295463618378 0.499681268541635 no 1677 0.493405965358619 2358 24207260
SGTC_3102 9121669 49.47 µM 0.0164121862417956 0.499728073606703 no 1678 0.493452778922067 2313 41905072
SGTC_1180 1193-0155 285 µM 0.0150485172533216 0.499728073606703 no 1679 0.493996736792189 2370 2921347
SGTC_424 splitomicin 100 mM 0.0147243485011538 0.499598790011621 no 1680 0.494126047084093 2302 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1761 st044296 37 µM 0.0126502358640409 0.498771602857334 no 1681 0.494953420656536 2381 1826700
SGTC_1212 0520-0165 585 µM 0.0122353460799813 0.498606139123562 no 1682 0.495118924919484 2374 5403258
SGTC_3083 9117465 49.47 µM 0.0105797606109633 0.497945871611392 no 1683 0.495779364912794 2348 16420915
SGTC_786 4544-0069 423 µM 0.00859612461085016 0.497154781145889 no 1684 0.496570684679122 2367 748821 YLR208W SEC13
SGTC_2569 tetrandrine 100 µM 0.00758402694686744 0.496751152330055 no 1685 0.496974439998975 2382 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2095 5432005 200 µM 0.00623838125042085 0.496214508373188 no 1686 0.497511262100489 2395 783734
SGTC_1263 0774-1208 64.8 µM 0.00603843909147927 0.496134771933883 no 1687 0.497591025978424 2388 906585
SGTC_1519 esterone 74 µM 0.00528026002407816 0.49583241342374 no 1688 0.497893490813535 2390 698 A steroid.
SGTC_929 2805-0021 398 µM 0.00512808510633818 0.495771727012186 no 1689 0.497954199000081 2342 3098024
SGTC_1380 2291-0730 164 µM 0.00456562393352369 0.495547421851865 no 1690 0.498178585904379 2393 2999191
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.00156604394790641 0.494351238081123 no 1691 0.499375239111584 2401 6312947
SGTC_659 k018-0002 107 µM 0.00140643517274285 0.494287590022451 no 1692 0.499438913729926 2401 6797879 YHR007C ERG11
SGTC_3034 9090421 49.47 µM 0.000731845858102594 0.49401858200079 no 1693 0.499708035770529 2395 17173761
SGTC_1406 3909-7906 11.9 µM 0.000584771629782798 0.493959933122781 no 1694 0.499766709885796 2404 X1406
SGTC_2677 mitomycin C 100 µM 0 0.493726744694139 no 1695 0.5 2406 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2029 5175081 200 µM -5.96604045642905e-05 0.493702954131125 no 1696 0.499976198942168 2406 1380876
SGTC_3242 9133940 49.47 µM -0.000918565096200645 0.493360454348454 no 1697 0.499633545597358 2408 17248444
SGTC_2414 st077232 92.9 µM -0.00160385433096626 0.493087189559527 no 1698 0.49936015497009 2412 729801
SGTC_1310 1188-0297 994 nM -0.00247675181632214 0.492739119133097 no 1699 0.499011919992605 2410 1588352
SGTC_814 3342-0569 96 µM -0.00327947914416894 0.492419034135591 no 1700 0.498691679456858 2410 4346283
SGTC_247 mechlorethamine 29.705 µM -0.00330942673501481 0.492407092721093 no 1701 0.498679732161508 2410 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1746 st038117 42 µM -0.0044287261485843 0.4919607840552 no 1702 0.498233199666569 2425 2898218
SGTC_1059 3448-6867 171 µM -0.00487314567952792 0.491783579282166 no 1703 0.49805590384447 2410 3934407
SGTC_1454 4239-0054 42.6 µM -0.00688738400476964 0.490980456655311 no 1704 0.497252353042078 2425 1340767
SGTC_1251 0490-5699 265 µM -0.00700227268385801 0.49093464899765 no 1705 0.497206520195762 2417 3883818
SGTC_205 1486-1330 71.903 µM -0.00771026918696643 0.490652363955161 no 1706 0.496924078104436 2412 4118834
SGTC_1000 4048-0884 8.67 µM -0.00820472805586542 0.490455221197627 no 1707 0.496726823803068 2428 13040088
SGTC_391 gliotoxin 8.33 µM -0.00905607632554975 0.49011579067835 no 1708 0.496387197641767 2432 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2697 mebhydrolin 72.4 µM -0.00917345629067114 0.490068992122902 no 1709 0.496340371755998 2426 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_537 1334-0398 209 µM -0.0109072951299674 0.489377739204695 no 1710 0.495648705086274 2426 5846986
SGTC_3074 9116018 49.47 µM -0.0109879176105318 0.489345597113056 no 1711 0.495616543297389 2424 17027303
SGTC_3203 9113543 49.47 µM -0.011075614107864 0.489310634873005 no 1712 0.495581559585593 2461 17018012
SGTC_2357 9067248 200 µM -0.0114739634485285 0.489151824718946 no 1713 0.495422651292883 2428 9150235
SGTC_891 0929-0073 133 µM -0.0115572513625421 0.489118620496317 no 1714 0.495389426425581 2453 5603632
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0119099364839074 0.488978017077648 no 1715 0.495248735105058 2435 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2778 tioconazole 65.09 nM -0.0120228102403488 0.488933018484511 no 1716 0.495203708215197 2426 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1131 3454-3128 32.3 µM -0.0135341109631476 0.488330532565579 no 1717 0.494600835739089 2481 710982
SGTC_1697 st025554 27.742 µM -0.0136102288731414 0.488300188557181 no 1718 0.494570471883201 2428 1269519
SGTC_2377 9073351 62.6 µM -0.0141507588826347 0.488084711042318 no 1719 0.494354852383714 2428 7337946 YHR072W ERG7
SGTC_1578 josamycin 24.2 µM -0.0145493333327473 0.487925825081956 no 1720 0.494195860555674 2436 5282165 A P450 substrate.
SGTC_2407 paclitaxel 400 µM -0.0146277877310392 0.487894550591677 no 1721 0.494164565109541 2541 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_605 1315-0399 119 µM -0.016311716217173 0.487223299858986 no 1722 0.493492855297934 2451 24020461
SGTC_1410 3909-8106 77.9 µM -0.0169904730724569 0.486952742655797 no 1723 0.493222108031599 2443 1039210
SGTC_1456 k015-0012 13 µM -0.0170459222253064 0.486930640501468 no 1724 0.493199990223219 2428 2989616
SGTC_399 oxolinic acid 75 µM -0.0172153685678741 0.486863099065553 no 1725 0.493132400831076 2448 4628 A DNA gyrase inhibitor.
SGTC_2131 toluylene red 5.2905 µM -0.0172444148991859 0.486851521214454 no 1726 0.493120814741329 2439 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_343 4130-2827 29.8 µM -0.0172525542001802 0.486848276895707 no 1727 0.493117568113018 2459 1118244
SGTC_660 4031-1742 102 µM -0.0173201013769529 0.48682135267966 no 1728 0.493090624714162 2440 6738706
SGTC_2937 9044753 11.33 µM -0.0177041570204395 0.486668269749366 no 1729 0.492937432172827 2444 6465530 YGL099W LSG1
SGTC_2007 4011539 71.82 µM -0.0187102476538742 0.486267255714484 no 1730 0.49253612662051 2442 45595301
SGTC_1787 fluconazole 80 µM -0.0193768079276391 0.48600158148289 no 1731 0.492270255763985 2458 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1688 st021091 57.6 µM -0.0196459971657039 0.48589429114883 no 1732 0.492162885235464 2429 3656366
SGTC_2247 cerulenin 830 nM -0.0203199155444611 0.485625693048459 no 1733 0.491894084379665 2477 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_796 1234-0020 70.7 µM -0.0217188991289339 0.485068132637545 no 1734 0.491336094001735 2446 46495034
SGTC_2059 5238311 157 µM -0.0218556363517291 0.485013638005384 no 1735 0.49128155668786 2448 703021
SGTC_2443 5493264 126.67 µM -0.0221255407182189 0.484906072366653 no 1736 0.491173906456947 2465 5340055
SGTC_1782 st039423 80.636 µM -0.0222042188373018 0.484874716792329 no 1737 0.491142526137949 2467 2068169
SGTC_1694 st024011 44.9 µM -0.0226301875222937 0.484704957210322 no 1738 0.490972631914583 2444 2787533
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0238493424582641 0.484219107737344 no 1739 0.490486390818269 2458 688669
SGTC_2857 9024691 58.44 µM -0.0239543981166585 0.484177242744981 no 1740 0.490444491644555 2487 16478292
SGTC_1385 3091-4834 14.1 µM -0.0247734708800462 0.483850845829632 no 1741 0.490117825866649 2470 4072814
SGTC_1594 piperine 70.1 µM -0.0262188547011946 0.483274893228711 no 1742 0.489541388587368 2456 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3282 9108498 15.4605 µM -0.0264374797256507 0.483187779134513 no 1743 0.489454200045314 2489 16459645
SGTC_3097 9117246 49.47 µM -0.0266522525915727 0.483102200766394 no 1744 0.489368548250305 2450 16423892
SGTC_2777 climbazole 1.536 µM -0.0270545577686081 0.482941900396041 no 1745 0.489208109563671 2456 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2220 6782180 200 µM -0.0284173538442385 0.482398908600403 no 1746 0.488664641712141 2461 833803
SGTC_333 3486-0131 40.1 µM -0.0290373631553223 0.482151883141219 no 1747 0.488417395829925 2470 6744690
SGTC_1714 st033236 13.627 µM -0.0293565211778584 0.482024726172698 no 1748 0.488290124459675 2471 2916566
SGTC_2699 st077704 54.6 µM -0.0300761002171089 0.481738042664176 no 1749 0.488003180685148 2489 645852
SGTC_2521 angolensin 13.4 µM -0.0302960742163621 0.481650405916558 no 1750 0.487915463729378 2508 821428 A flavenoid.
SGTC_171 k064-0041 9.68 µM -0.0311357069638097 0.481315907829352 no 1751 0.487580656713007 2460 53325
SGTC_187 1488-2104 32.728 µM -0.0318498863024169 0.481031398990619 no 1752 0.487295881639541 2513 2852859
SGTC_2776 terbinafine 19.92 µM -0.0326026740466748 0.480731520117557 no 1753 0.48699571869233 2456 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2866 9034245 58.44 µM -0.0327525108300386 0.480671832761261 no 1754 0.486935974371101 2533 6462273
SGTC_1778 st046819 58.9 µM -0.0329511050459373 0.480592723590828 no 1755 0.486856789483197 2465 671715
SGTC_2338 7999974 200 µM -0.0338331336983096 0.48024138046667 no 1756 0.486505107096146 2516 315925
SGTC_3076 9116187 49.47 µM -0.0355171158503166 0.47957063383321 no 1757 0.48583369925531 2494 27241210
SGTC_1991 st073000 8.92 µM -0.038223019147296 0.478492967925312 no 1758 0.484754933839466 2546 4301969 YIL048W NEO1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.03901811229244 0.478176339884234 no 1759 0.484437974043908 2476 16623 A steroid.
SGTC_694 1315-0438 43.2 µM -0.0408230369885803 0.477457620477698 no 1760 0.483718486901898 2511 6793154
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0413515250685133 0.477247190766686 no 1761 0.48350782855263 2554 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2864 9034755 47.6 µM -0.0413811713613925 0.477235386599182 no 1762 0.483496011507784 2476 4930451
SGTC_2017 5132927 60.65 µM -0.0418385492001213 0.477053276497978 no 1763 0.483313702043241 2507 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2126 5251174 33.877 µM -0.043066364025889 0.476564432098549 no 1764 0.482824316014659 2486 790722
SGTC_867 0518-0118 155 µM -0.0430907874485453 0.476554708468501 no 1765 0.482814581515386 2498 6848158
SGTC_2842 9000675 19.48 µM -0.0437917500694643 0.476275642122017 no 1766 0.482535201634054 2532 2989072
SGTC_2385 9074692 200 µM -0.0438251004205581 0.47626236501158 no 1767 0.482521909530016 2489 17046906
SGTC_2009 4012297 12.05 µM -0.0449939395330633 0.475797055149504 no 1768 0.48205606980793 2523 45595307
SGTC_3309 9129340 25.759 µM -0.0451422701541678 0.475738007709091 no 1769 0.481996954517783 2533 17158987
SGTC_2183 6420625 130.508 µM -0.0454539192746783 0.475613948192316 no 1770 0.481872751999507 2481 2897619
SGTC_5 0352-0601 109.883 µM -0.0455408029867255 0.475579362437205 no 1771 0.481838126269657 2441 762456
SGTC_1520 flindersine 88 µM -0.0459478901380737 0.47541731591669 no 1772 0.481675891824583 2579 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1521 st012942 49.4 µM -0.0461955527067988 0.475318732484983 no 1773 0.481577193559145 2637 24207259
SGTC_2239 6685329 187.64 µM -0.0470393079146218 0.474982882516998 no 1774 0.481240949501208 2623 805680
SGTC_1087 pterostilbene 9.05 µM -0.0484617219324523 0.474416742433296 no 1775 0.480674135025633 2522 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2690 usnic acid 100 µM -0.0492847230694143 0.474089200329382 no 1776 0.480346196973578 2538 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1816 st051957 91.6 µM -0.0493293910662157 0.474071423635967 no 1777 0.480328398669722 2490 674121
SGTC_2431 5490079 200 µM -0.0494398662894638 0.474027457610939 no 1778 0.480284379143321 2516 5722345
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0497710995268994 0.473895638016735 no 1779 0.480152398683189 2592 94937 An inhibitor of serotonin biosynthesis.
SGTC_2049 5262831 67.185 µM -0.0506289585360605 0.473554252548918 no 1780 0.479810593417696 2507 763417
SGTC_2330 7979373 200 µM -0.0510531353190365 0.473385458323278 no 1781 0.479641589928202 2514 1863007
SGTC_2983 9022671 12.99 µM -0.0510856863105933 0.473372505384653 no 1782 0.479628620884615 2602 6405161
SGTC_2167 5876490 200 µM -0.0512387005825412 0.473311617156927 no 1783 0.479567656863124 2681 686534
SGTC_1163 k060-0048 49.9 µM -0.0525033743579911 0.472808395655706 no 1784 0.47906380334814 2482 6809982
SGTC_1132 3456-3614 2.5 µM -0.0534220500503291 0.47244287609238 no 1785 0.478697818448237 2566 3125502
SGTC_2321 7390090 138.78 µM -0.0549314167642084 0.471842384918416 no 1786 0.478096551349307 2562 649046
SGTC_1329 1447-1697 50.6 µM -0.0559262598908822 0.471446628327007 no 1787 0.477700275597955 2619 2840515
SGTC_2846 9008642 19.48 µM -0.0564051445213527 0.471256134200287 no 1788 0.477509529373339 2599 2992898
SGTC_3163 9099914 49.47 µM -0.0574762718181092 0.470830077452436 no 1789 0.477082903600708 2512 16268368
SGTC_3068 9116768 49.47 µM -0.0578329914359407 0.470688194327492 no 1790 0.476940829391349 2559 41904888
SGTC_1474 0330-0125 5.35 µM -0.0589729058816095 0.470234825107771 no 1791 0.476486844258015 2526 X1474
SGTC_1447 4239-0816 81.9 µM -0.0605444779657951 0.469609839468008 no 1792 0.475860996252781 2523 1341554
SGTC_638 3970-0837 4.09 µM -0.0608022866503785 0.469507320749493 no 1793 0.475758334604615 2537 4118451 YLR208W SEC13
SGTC_2872 9044037 25.97 µM -0.0622123998713113 0.468946619182081 no 1794 0.47519684397478 2521 6465195
SGTC_940 3232-1287 54.8 µM -0.0631222926764204 0.468584852256541 no 1795 0.474834561353032 2507 1585493 YIL048W NEO1
SGTC_2163 5671233 125 µM -0.0641711189322636 0.468167878576965 no 1796 0.474416986867901 2531 701023
SGTC_637 1181-0519 7.26 µM -0.0647675136349554 0.467930790128134 no 1797 0.474179553742545 2515 6252091 YGR060W ERG25
SGTC_44 0929-0055 61.211 µM -0.0650452573915929 0.467820380823874 no 1798 0.474068983168739 2530 1379590
SGTC_1676 st018489 23.4 µM -0.0651109018457928 0.467794286058542 no 1799 0.47404285021769 2579 3696235
SGTC_1234 0326-0494 15.5 µM -0.0667468030564852 0.467144033029413 no 1800 0.473391636955888 2617 1547813
SGTC_1193 1488-0126 41.5 µM -0.066990960346378 0.467046990625799 no 1801 0.473294449816783 2559 1384710
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.0672276806566779 0.466952905983411 no 1802 0.473200224495119 2564 688801
SGTC_2127 5253358 187.912 µM -0.0672392050890745 0.466948325637298 no 1803 0.473195637291354 2517 20612
SGTC_234 nsc-17383 10.7 µM -0.0675084483088834 0.466841317090306 no 1804 0.473088468296309 2544 408974
SGTC_2610 ononetin 44.17 µM -0.0675351254617768 0.46683071460134 no 1805 0.473077849885395 2565 259632
SGTC_1926 methyl fluorone black 53.6 µM -0.069409323914983 0.466085898039443 no 1806 0.472331903704726 2512 72721 Reacts with homocysteine.
SGTC_2695 st077686 51.995 µM -0.0699203004339398 0.465882853712714 no 1807 0.472128547630861 2564 2876092
SGTC_2390 9097792 176.6 µM -0.0700946950381276 0.46581355738228 no 1808 0.472059144532439 2550 4497149
SGTC_2104 5389443 200 µM -0.0708165643456449 0.465526731034961 no 1809 0.471771874240792 2624 2244536
SGTC_3099 9120367 49.47 µM -0.0709587086187667 0.465470253772046 no 1810 0.471715309180392 2541 24824940
SGTC_2742 clothiapine 36.27 µM -0.0717867261003837 0.465141276813599 no 1811 0.471385818301068 2522 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_787 4152-0075 138 µM -0.0717936130603633 0.465138540677302 no 1812 0.471383077872505 2564 9566539
SGTC_1887 st057648 70.8 µM -0.0720943704594366 0.465019053682434 no 1813 0.471263403145912 2586 688672
SGTC_2966 9084041 48.03 µM -0.0721481415232135 0.464997691471648 no 1814 0.471242007312486 2515 17741380
SGTC_1409 3909-8004 61.9 µM -0.0727322301427549 0.464765650794909 no 1815 0.471009600257988 2564 2119279
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0731263389652993 0.464609090089016 no 1816 0.470852791150359 2540 136420
SGTC_3352 9151559 45.5865 µM -0.0733550631656694 0.464518231344988 no 1817 0.470761787804182 2585 17159339
SGTC_606 k015-0008 38.6 µM -0.0744643954537109 0.464077584858165 no 1818 0.470320435398248 2571 1970475
SGTC_1 0258-0098 57.368 µM -0.0750577921228435 0.4638418952154 no 1819 0.470084365028782 2537 6790032 YDR047W HEM12
SGTC_2798 7813637 45.45 µM -0.0767803539208578 0.463157787658473 no 1820 0.469399139947416 2622 956368
SGTC_2102 5377816 72.7585 µM -0.076837339179741 0.463135158073437 no 1821 0.469376473079718 2602 1379702
SGTC_1298 1079-1278 263 µM -0.0777785794742416 0.462761396663347 no 1822 0.469002092962457 2564 2840950
SGTC_2380 9035439 200 µM -0.0781590083658088 0.462610339726369 no 1823 0.468850784405916 2678 6462575
SGTC_910 3454-3003 490 µM -0.079067879562422 0.462249476021165 no 1824 0.468489315948868 2535 820824
SGTC_2399 5884133 200 µM -0.0794841519119505 0.462084207091648 no 1825 0.468323768335303 2580 722445
SGTC_330 1488-0319 80.1 µM -0.0800068590917718 0.461876690556974 no 1826 0.468115900347474 2613 6846614
SGTC_3036 9090181 49.47 µM -0.0805917488423256 0.461644499635197 no 1827 0.46788331416529 2543 25236586
SGTC_870 0573-2213 57.6 µM -0.0814083776290916 0.461320334285724 no 1828 0.467558593421102 2545 3916321
SGTC_3268 9137683 49.47 µM -0.0818151205786984 0.461158884978164 no 1829 0.467396865951269 2529 1953228
SGTC_447 ml7 120 µM -0.0828152350830358 0.460761934766623 no 1830 0.466999227448552 2579 4216 Selective myosin light chain kinase inhibitor.
SGTC_1374 2889-5571 141 µM -0.0829418839147733 0.460711670022649 no 1831 0.466948875103636 2601 2853281
SGTC_3277 9138724 49.47 µM -0.0830021339561439 0.460687758037347 no 1832 0.46692492140967 2597 15943418
SGTC_1066 ketoconazole 628 nM -0.0836446916739218 0.460432749134887 no 1833 0.46666946629954 2633 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1204 4049-0315 18.3 µM -0.0847794811882495 0.459982430291954 no 1834 0.466218353220093 2801 588402
SGTC_113 0099-0221 2.5 µM -0.0848920359685159 0.459937767935284 no 1835 0.466173611654342 2546 89219
SGTC_2749 bexarotene 57.39 µM -0.0855203566400198 0.459688456135598 no 1836 0.465923856248557 2606 82146 An retinoic acid receptor inhibitor.
SGTC_1018 4259-0013 28.1 µM -0.0881690545888053 0.45863765280824 no 1837 0.464871156183151 2708 6801262
SGTC_1301 naphtanilide LB 4.81 µM -0.0882036977996017 0.458623910896818 no 1838 0.464857389177726 2616 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_753 1322-0200 289 µM -0.0883161587926016 0.45857930137134 no 1839 0.464812698139633 2675 5403907
SGTC_3207 9114163 49.47 µM -0.0886337521796033 0.458453325484619 no 1840 0.464686491638775 2628 849233
SGTC_2259 7964009 200 µM -0.0890468708521587 0.4582894649966 no 1841 0.464522330244769 2726 313134
SGTC_425 3825-7017 13.1 µM -0.0894787242230321 0.458118181106081 no 1842 0.464350730680654 2799 3397440
SGTC_2508 celastrol 40.54 µM -0.0897527939508335 0.458009482202289 no 1843 0.464241830844368 2544 122724 Celastrol is a natural product and antioxidant.
SGTC_2189 6047310 154.431 µM -0.0917073330570694 0.457234383204882 no 1844 0.463465285505175 2547 711535
SGTC_751 0833-0568 350 µM -0.0930679217040974 0.456694919161029 no 1845 0.462924800784797 2620 6954252
SGTC_1437 4092-1038 11.6 µM -0.0937447531415277 0.456426589810326 no 1846 0.462655959460447 2575 3977136
SGTC_3137 9097352 49.47 µM -0.0948078468403224 0.456005167215332 no 1847 0.462233727036599 2729 44120435
SGTC_310 1273-0058 1.06 µM -0.0991633671318595 0.454279110558516 no 1848 0.460504280125362 2607 2734232
SGTC_7 0192-1582 4.227 µM -0.10040399029912 0.453787618369077 no 1849 0.460011800988193 2599 252616
SGTC_3115 9123671 49.47 µM -0.101782610744361 0.453241539449477 no 1850 0.459464614287629 2574 3286988
SGTC_14 0354-0009 295 µM -0.102488425178785 0.452961996735303 no 1851 0.459184499919767 2563 1713507
SGTC_57 miconazole 162.5 nM -0.104059945597819 0.452339669075698 no 1852 0.458560888508646 2556 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3127 9126946 49.47 µM -0.105155764282009 0.451905790177248 no 1853 0.458126105517648 2698 27243249
SGTC_581 0958-0271 211 µM -0.108873513941447 0.45043421387902 no 1854 0.456651407277401 2583 4591145
SGTC_1351 1496-0003 46.5 µM -0.10995835689946 0.4500049339693 no 1855 0.456221200482601 2678 3891978
SGTC_1276 0871-0068 94.2 µM -0.110285003170825 0.449875689200882 no 1856 0.45609167522304 2693 3414906
SGTC_1845 st056753 3.01 µM -0.110418802638098 0.449822750038358 no 1857 0.456038620979086 2558 5375839
SGTC_1488 4013-0813 75.9 µM -0.110523810292954 0.449781203283752 no 1858 0.455996983830549 2585 2910057
SGTC_2028 5153890 36.43 µM -0.11084886898139 0.449652595831695 no 1859 0.455868096131477 2614 2830968 YPR165W RHO1
SGTC_1753 st043925 64 µM -0.110864617332988 0.449646365228352 no 1860 0.455861851934446 2624 670181
SGTC_3189 9110682 49.47 µM -0.111900669540512 0.449236493777425 no 1861 0.455451082861242 2682 17122418
SGTC_2997 9067075 71.4286 µM -0.112990812813832 0.448805281904443 no 1862 0.455018919440464 2683 27209819
SGTC_3152 9099253 49.47 µM -0.113868358745405 0.448458207926679 no 1863 0.454671074225132 2682 25236131
SGTC_1210 3013-0140 750 nM -0.116408839386456 0.447453657951193 no 1864 0.453664265102925 2743 905973
SGTC_2888 9058547 12.99 µM -0.116599917647823 0.447378115848004 no 1865 0.453588551493927 2638 16476514
SGTC_1141 3253-0389 52.6 µM -0.117905928569976 0.446861840381327 no 1866 0.453071097849276 2592 5402031
SGTC_1984 st072354 53.1 µM -0.118144631885678 0.446767488958869 no 1867 0.452976529967246 2624 5762938
SGTC_843 0310-0051 143 µM -0.118263819020542 0.446720379405599 no 1868 0.452929312203773 2629 2065037
SGTC_831 k061-1017 217 µM -0.118277767078756 0.446714866386627 no 1869 0.452923786515693 2693 1240153
SGTC_1799 st045822 46.1415 µM -0.119430565597978 0.446259254422622 no 1870 0.45246712337183 2620 3674992
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.122977641175163 0.444857817715199 no 1871 0.45106240165643 2727 521171
SGTC_301 4119-0100 24.5 µM -0.123595333958289 0.444613839478241 no 1872 0.450817843560635 2635 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_632 0781-2353 4.65 µM -0.125403711724853 0.44389968171739 no 1873 0.450101974890982 2711 6811515 YHR007C ERG11
SGTC_2093 5331342 194.4 µM -0.125765504102631 0.443756825820113 no 1874 0.449958774323154 2726 33839
SGTC_864 0469-0573 172 µM -0.126376823841043 0.443515459159882 no 1875 0.449716823472749 2618 689425
SGTC_3022 9087993 49.47 µM -0.127125374089669 0.443219938483861 no 1876 0.449420584384955 2634 17173644
SGTC_816 0325-0417 81.3 µM -0.128010535768799 0.442870525649015 no 1877 0.449070317651535 2697 68101
SGTC_3124 9127567 49.47 µM -0.128016698662128 0.442868093035284 no 1878 0.449067879075962 2715 17592030
SGTC_2709 st078560 56 µM -0.128129352326374 0.442823626824946 no 1879 0.449023303846549 2683 17250903
SGTC_3139 9095020 49.47 µM -0.128325386013399 0.442746250897952 no 1880 0.448945738027564 2594 25236292
SGTC_3323 9138564 53.9225 µM -0.1287039040092 0.442596853263885 no 1881 0.448795973076716 2690 43912313 YNL103W MET4
SGTC_2675 theaflavin digallate 100 µM -0.130987370335365 0.441695763620136 no 1882 0.447892649165846 2667 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2953 9074162 66.49 µM -0.13224464819858 0.441199751620703 no 1883 0.447395393529869 2698 16451992
SGTC_261 5-fluorouridine 15.376 µM -0.133546447668312 0.440686272464361 no 1884 0.446880616642746 2783 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1257 0669-0121 16 µM -0.134253524519229 0.440407416230832 no 1885 0.446601051257082 2742 4307855
SGTC_743 1275-0778 158 µM -0.134836614119621 0.440177480187969 no 1886 0.446370528144692 2753 2849257 YMR203W TOM40
SGTC_684 1140-0066 328 µM -0.134877087949083 0.44016152045192 no 1887 0.446354527582467 2701 6813534
SGTC_1712 st032288 53.4 µM -0.135270509491022 0.440006390609592 no 1888 0.446199000379077 2680 2883011
SGTC_393 acivicin 6.25 µM -0.135713446572351 0.439831747343321 no 1889 0.446023908623856 2671 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_48 0382-0018 55 µM -0.136077644807954 0.439688158359731 no 1890 0.445879949991298 2861 762596
SGTC_2234 tolnaftate 200 µM -0.13657379094509 0.439492560297906 no 1891 0.445683847071837 2660 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_417 st075190 100 µM -0.137477458298752 0.439136341184191 no 1892 0.445326704614063 2747 222757
SGTC_1995 st072814 61.1 µM -0.137675128028106 0.439058427770569 no 1893 0.445248588571101 2660 5769371
SGTC_1062 mesoridazine 14.2 µM -0.138278352422741 0.438820675717645 no 1894 0.445010216704403 2633 4078 A neuroleptic.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.138681885839955 0.438661641252823 no 1895 0.444850766385879 2645 5106787 A p450 inhibitor.
SGTC_1173 0443-0020 122 µM -0.139018731798984 0.438528896218987 no 1896 0.444717673471453 2681 5331295
SGTC_1516 st013856 110 µM -0.139629859547656 0.438288079247259 no 1897 0.444476223609527 2790 5281404 A mutagen and neurotoxin.
SGTC_3016 9080866 49.47 µM -0.140594465433851 0.437908019539915 no 1898 0.444095160375635 2662 17066299
SGTC_485 niflumic acid 177 µM -0.140889095364435 0.437791945225383 no 1899 0.443978778427897 2781 4488 A COX2 inhibitor.
SGTC_1703 st026983 48.3 µM -0.141171770050065 0.437680585907728 no 1900 0.443867123469469 2714 1104023
SGTC_1039 k821-0043 94 µM -0.141226984784095 0.437658834712398 no 1901 0.443845314470681 2661 15992768
SGTC_2962 9082311 13.18 µM -0.141244031657494 0.437652119335093 no 1902 0.443838581243564 2664 16459453
SGTC_1403 3909-7815 62.9 µM -0.141692338321563 0.437475521648185 no 1903 0.443661513507117 2640 6615483
SGTC_1739 st037196 92.5 µM -0.141777760377185 0.437441873465371 no 1904 0.443627775622303 2731 612214
SGTC_2917 7979103 53.79 µM -0.14196790288513 0.437366976987719 no 1905 0.443552679317943 2788 2980565
SGTC_3191 9110352 49.47 µM -0.142128731307054 0.437303628979263 no 1906 0.44348916212032 2621 17122424
SGTC_111 0083-0039 52.457 µM -0.143005072655461 0.436958478973242 no 1907 0.443143087486374 2643 759313
SGTC_820 1582-0060 59.9 µM -0.143005443737498 0.43695833283147 no 1908 0.443142940952096 2700 3848840
SGTC_839 0122-0028 230 µM -0.143714543374439 0.436679086662029 no 1909 0.442862943234776 2654 759448
SGTC_2105 5350118 200 µM -0.143997979558392 0.436567477218919 no 1910 0.442751032544083 2705 2133313
SGTC_1260 0700-1617 7.75 µM -0.146165932967158 0.435713963924727 no 1911 0.441895199119314 2745 2853078
SGTC_2048 5246248 200 µM -0.146790756302004 0.435468029243263 no 1912 0.441648590524425 2693 677046
SGTC_1938 st074717 56.4 µM -0.146857397009688 0.435441800482161 no 1913 0.441622289748827 2622 17250979
SGTC_705 1124-0212 310 µM -0.146946644444169 0.435406674504783 no 1914 0.441587067285577 2672 9554485
SGTC_692 k241-0027 77.8 µM -0.147229332836227 0.435295417460829 no 1915 0.441475504310741 2803 3600480
SGTC_200 k038-0079 37.545 µM -0.147700759419882 0.435109890542328 no 1916 0.441289466140367 2707 3436683
SGTC_758 0868-0029 16 µM -0.147966874107283 0.435005169113164 no 1917 0.441184455527841 2806 762687
SGTC_608 k048-0125 159 µM -0.148444644761097 0.434817168290698 no 1918 0.440995934454125 2738 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.148642106161667 0.434739472328657 no 1919 0.440918023074424 2810 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1452 4194-0072 190 µM -0.150250468039339 0.434106717586551 no 1920 0.440283505022247 2848 1343545
SGTC_2820 7989630 71.43 µM -0.153010239185163 0.433021374588793 no 1921 0.439195100336827 2705 2984098
SGTC_1548 st061468 90.8 µM -0.153490218403489 0.432832663131064 no 1922 0.439005851745485 2762 390799
SGTC_556 4058-0063 51.5 µM -0.15437593380305 0.432484470288591 no 1923 0.438656664108865 2686 6615692
SGTC_98 0074-0023 107.663 µM -0.155098020819548 0.43220064188967 no 1924 0.438372021231512 2750 3563821
SGTC_2515 chrysin 20.77 µM -0.155264419289434 0.432135241138334 no 1925 0.438306432349957 2788 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_719 2810-4230 27.3 µM -0.155472956213492 0.432053281042322 no 1926 0.438224236248794 2665 721079
SGTC_288 1315-0019 35.1 µM -0.156394321134029 0.431691197211462 no 1927 0.437861106588163 2734 6811474
SGTC_47 0149-0135 24.25 µM -0.156771460573953 0.431543003096245 no 1928 0.437712482927062 2652 5239155
SGTC_2317 5986382 200 µM -0.157331144406298 0.431323097295174 no 1929 0.437491938107522 2754 877883
SGTC_20 0481-0013 4.944 µM -0.158759343153185 0.430762039253725 no 1930 0.436929240966224 2684 182045
SGTC_1247 0448-0043 5.84 µM -0.159524295776253 0.430461590269184 no 1931 0.436627909075299 2791 3089013 YGL099W LSG1
SGTC_1055 3448-0672 86 µM -0.160162797245804 0.430210838076056 no 1932 0.436376417259464 2840 748378
SGTC_1346 1488-2224 62.4 µM -0.160893091095249 0.429924071701784 no 1933 0.43608880196003 2679 3722427
SGTC_2469 5655019 90.81 µM -0.161351061817053 0.429744258002871 no 1934 0.435908454278405 2843 2788239
SGTC_1834 st055981 52.8 µM -0.161820156566178 0.429560091769493 no 1935 0.435723739799598 2855 471719 YDL150W RPC53
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.161850798248616 0.42954806240173 no 1936 0.435711674574462 2675 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_643 k048-0106 28.4 µM -0.16217101150779 0.429422356410243 no 1937 0.43558559353069 2804 6763920
SGTC_916 4466-0038 42 nM -0.163244493464504 0.429000992306288 no 1938 0.435162967659263 2768 5722064 YGL116W CDC20
SGTC_2153 5569715 200 µM -0.163585533842416 0.428867143740391 no 1939 0.435028716803293 2696 2054701
SGTC_492 tmb-8 126 µM -0.165405803917845 0.42815287866093 no 1940 0.434312292866607 2728 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3098 9119039 49.47 µM -0.165641073529126 0.428060577139994 no 1941 0.434219710879529 2684 17161528
SGTC_2828 7998861 71.43 µM -0.165893993267119 0.427961355470485 no 1942 0.434120187337061 2756 2988188
SGTC_260 nsc-65238 3.989 µM -0.166074064855766 0.427890715267375 no 1943 0.434049331977982 2816 3246252
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.166145865263456 0.427862549361851 no 1944 0.43402108022917 2697 15053
SGTC_3326 9140064 16.379 µM -0.166531038613042 0.427711459615597 no 1945 0.43386952945496 2681 1868434
SGTC_378 3970-0959 8.33 µM -0.166725714281853 0.427635099335928 no 1946 0.433792935826469 2822 6615653
SGTC_2523 spermine 47.74 µM -0.167253859434657 0.427427951454473 no 1947 0.433585153750749 2796 1103 A DNA binding polyamine.
SGTC_164 4100-3994 89.624 µM -0.167894719566904 0.427176621632887 no 1948 0.433333052168714 2707 4615967
SGTC_415 dibenzyl ketone 100 µM -0.167895035732881 0.427176497647535 no 1949 0.433332927802017 2790 7593
SGTC_2045 5106652 78.05 µM -0.168482473222519 0.426946144865924 no 1950 0.433101865457452 2843 673349
SGTC_763 3453-1109 128 µM -0.16884317164059 0.426804715969676 no 1951 0.43295999986322 2690 1560353
SGTC_651 3253-0966 34.4 µM -0.171717662762665 0.425677973355801 no 1952 0.43182974960029 2741 781462
SGTC_342 k048-0088 23.3 µM -0.171853746014572 0.425624646429283 no 1953 0.431776255405107 2673 6820570
SGTC_3024 9090631 49.47 µM -0.171891249111738 0.425609950334469 no 1954 0.431761513193603 2725 25236383
SGTC_881 0833-0569 170 µM -0.172334300549947 0.425436342475686 no 1955 0.431587359896031 2726 5418700
SGTC_3247 9135149 49.47 µM -0.172401016157167 0.425410201494629 no 1956 0.431561136681254 2682 8934436 YOR116C RPO31
SGTC_39 0986-0283 58.349 µM -0.173596635426187 0.424941781196412 no 1957 0.431091238207048 2820 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2451 5856223 45.7 µM -0.173683868742439 0.424907609024825 no 1958 0.431056957856388 2751 2179896
SGTC_2468 5987765 72.9 µM -0.173972061122796 0.424794718562282 no 1959 0.430943709683904 2761 26772094
SGTC_1004 4084-0029 199 µM -0.174690845154586 0.424513184016146 no 1960 0.430661280834679 2854 716894 YLR208W SEC13
SGTC_914 3820-6779 408 µM -0.176204440390527 0.423920462560145 no 1961 0.430066666221118 2694 2893481
SGTC_3172 9105863 49.47 µM -0.176336159374101 0.423868889737672 no 1962 0.430014928010208 2760 2348785
SGTC_219 mitoxanthrone 164.414 µM -0.176667403897396 0.423739201098637 no 1963 0.42988482300372 2792 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1121 fusaric acid 630.51 nM -0.177521578421179 0.423404813392399 no 1964 0.429549358637011 2744 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1391 3442-0225 151 µM -0.178038380160255 0.423202525359038 no 1965 0.429346417105986 2722 5227075
SGTC_1718 roemerine 11.9335 µM -0.178325476654408 0.423090157960993 no 1966 0.429233685994415 2824 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3092 9117248 49.47 µM -0.178353117600342 0.423079339833671 no 1967 0.42922283282406 2718 17141857
SGTC_1480 1070-0044 41.2 µM -0.178804563159474 0.422902661058633 no 1968 0.429045581072847 2816 3124987
SGTC_826 1683-5028 118 µM -0.179183502614449 0.422754370408487 no 1969 0.428896808546288 2804 722377
SGTC_2775 cyproheptadine 69.59 µM -0.179707268271025 0.422549422840466 no 1970 0.42869119354455 2735 2913 A selective serotonin reuptake inhibitor.
SGTC_1964 st076914 61 µM -0.180184466244936 0.42236271528508 no 1971 0.428503876492914 2705 24208661
SGTC_834 0312-0008 75.7 µM -0.180342324590494 0.422300955772004 no 1972 0.428441915062355 2707 6385573 YIL048W NEO1
SGTC_2351 9026858 72.31 µM -0.182199041938333 0.421574689046759 no 1973 0.427713262416382 2726 1409300
SGTC_3302 9125395 16.351 µM -0.184311045945221 0.420748889671124 no 1974 0.426884724481171 2787 17599668
SGTC_322 k048-0136 19.3 µM -0.184732731043929 0.420584051273644 no 1975 0.426719336168374 2818 6823282
SGTC_2897 9048598 12.99 µM -0.184919058398199 0.420511219597166 no 1976 0.426646261172415 2756 6467404
SGTC_1802 st050112 57.9 µM -0.1858047825955 0.420165044785071 no 1977 0.42629892693837 2705 4662563
SGTC_336 4111-0029 111 µM -0.186287506207284 0.41997640395954 no 1978 0.426109652289088 2786 3131175
SGTC_745 0469-0705 296 µM -0.187662438048261 0.419439203027291 no 1979 0.425570638577592 2888 3486736
SGTC_459 nigericin 15.3 µM -0.18836948931965 0.419163008734486 no 1980 0.425293507768887 2844 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1556 plumbagin 1.48 µM -0.189626144145246 0.418672222082136 no 1981 0.424801049420561 2731 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1308 1187-1617 41.4 µM -0.190623021106719 0.418282981678997 no 1982 0.424410476338388 2715 2882570
SGTC_128 0906-2981 13.371 µM -0.190782861256481 0.418220577955635 no 1983 0.424347858392552 2885 6740226
SGTC_1935 st074532 41.6 µM -0.191094513298664 0.418098910768658 no 1984 0.424225773091692 2868 2829742
SGTC_725 1497-0963 19 µM -0.191148950185317 0.41807765972103 no 1985 0.424204448953147 2859 3549977
SGTC_513 4245-1575 41.7 µM -0.191903436047011 0.417783148521553 no 1986 0.423908922946477 2862 719745
SGTC_2074 5212007 75.395 µM -0.192696200868337 0.417473744924994 no 1987 0.423598449480844 2767 758611
SGTC_2525 harmine 47.85 µM -0.19419634704995 0.41688840150235 no 1988 0.423011071529037 2827 5280953 A monoamine oxidase inhibitor
SGTC_2231 micatex 6.853 µM -0.19507210862351 0.416546772355674 no 1989 0.422668248599889 2769 20737 An antifungal of unknown mechanism.
SGTC_1882 5615643 20 µM -0.195661584264616 0.416316857043844 no 1990 0.422437527239959 2710 2253075
SGTC_72 0744-0168 198.391 µM -0.195915593029832 0.416217793910327 no 1991 0.422338116152267 2759 677577
SGTC_2002 4023503 131 µM -0.196218297213426 0.416099746569113 no 1992 0.422219653661543 2802 4736863 YCR052W RSC6
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.19629819756744 0.416068588617509 no 1993 0.422188386040201 2760 2724 A muscle relaxant with antifungal properties.
SGTC_1489 4065-0444 182 µM -0.196352674318871 0.416047345159439 no 1994 0.422167067787082 2780 2877968
SGTC_1631 benzylvanillin 81.9 µM -0.197142735653189 0.415739284737081 no 1995 0.421857920694036 2902 75506
SGTC_318 1488-0629 67.2 µM -0.197227515985016 0.415706230294251 no 1996 0.421824749426701 2835 3662576
SGTC_2768 sulfasalazine 50.2 µM -0.197337947452414 0.41566317579424 no 1997 0.421781542693156 2812 5384001 An antioxidant and salicylic acid derivative.
SGTC_3306 9127676 59.7925 µM -0.197604461125895 0.415559272870315 no 1998 0.421677272079338 2827 41905287
SGTC_3051 9093778 49.47 µM -0.198089197797059 0.415370308746339 no 1999 0.421487638141496 2723 17217378
SGTC_88 0180-0332 8.668 µM -0.199007190746889 0.415012502682144 no 2000 0.421128559848515 2734 3101745
SGTC_3339 9145883 14.936 µM -0.199386412154863 0.414864714129143 no 2001 0.420980244312763 2901 2030670
SGTC_3230 9131665 49.47 µM -0.201061981342753 0.414211862934568 no 2002 0.420325054692566 2746 15943720
SGTC_2242 6630449 61.2675 µM -0.201452707241704 0.414059658601834 no 2003 0.420172302723334 2955 691249 YDR170C SEC7
SGTC_739 1486-1183 203 µM -0.202025885089037 0.413836404847267 no 2004 0.419948244010203 2835 4346692
SGTC_2561 acetosyringone 100 µM -0.202452536841389 0.413670241331997 no 2005 0.419781480079709 2751 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3123 9126162 49.47 µM -0.204203166982317 0.412988604195043 no 2006 0.419097368303808 2745 25239884
SGTC_2688 kanamycin b 96.69 µM -0.205592012322614 0.412448020466435 no 2007 0.41855480874286 2888 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2585 alliin 100 µM -0.206794438273209 0.411980131286551 no 2008 0.418085199943386 2968 87310 A garlic compound which reacts with lipids.
SGTC_2404 5161160 200 µM -0.207191817685543 0.411825530086011 no 2009 0.417930028606473 2740 2831543
SGTC_2560 caryophyllene 100 µM -0.207646020634777 0.411648838345451 no 2010 0.417752684087171 2759 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_115 0527-0192 112.043 µM -0.208209386708543 0.411429705410936 no 2011 0.41753273983262 2858 4233931
SGTC_2458 5808907 16.39 µM -0.208423359834358 0.411346483355339 no 2012 0.417449209148728 2841 2731747
SGTC_1500 4488-1866 171 µM -0.209386698472714 0.410971854818858 no 2013 0.417073187855174 2933 2900003
SGTC_1889 st059080 5.18 µM -0.210163964564318 0.410669646379521 no 2014 0.416769851779995 2819 176925 Isolated from Daphnopsis sellowiana.
SGTC_2621 lithochol-11-enic acid 100 µM -0.210569450493797 0.410512010633581 no 2015 0.416611626386405 2810 6708711
SGTC_2374 9071832 200 µM -0.210757018648556 0.410439096971975 no 2016 0.416538439647826 2758 17381698
SGTC_2282 7944268 200 µM -0.210971310116369 0.410355798903735 no 2017 0.416454829348973 2964 2970414
SGTC_2496 diffractaic acid 79.83 µM -0.211498246058194 0.41015098879396 no 2018 0.416249250350955 3049 94870 An apoptosis inducer which activates caspases.
SGTC_1337 1486-1011 40.3 µM -0.211563675770925 0.410125559202038 no 2019 0.416223725174647 2781 X1337
SGTC_771 0250-0039 27.3 µM -0.212387451765393 0.409805426823557 no 2020 0.415902387260478 2780 3005115
SGTC_1654 st012436 41.8 µM -0.213432537375963 0.409399376564286 no 2021 0.415494801985113 2814 4323132
SGTC_2844 9010103 25.97 µM -0.213740786868805 0.409279629999413 no 2022 0.415374601467463 2971 2480525
SGTC_2417 cerulenin 830 nM -0.214454452526449 0.409002422756571 no 2023 0.415096341131098 2757 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1621 st003705 32.4 µM -0.215355875699392 0.408652350419441 no 2024 0.414744934467922 2961 24207032
SGTC_2740 felodipine 17.08 µM -0.215731105791562 0.408506649342409 no 2025 0.414598676585739 2887 3333 L-type calcium channel blocker
SGTC_216 k038-0035 28.382 µM -0.215932851690698 0.408428317048686 no 2026 0.414520044587086 2815 4444231 YPR107C YTH1
SGTC_178 4092-0806 87.505 µM -0.216326468178878 0.408275497303405 no 2027 0.414366639430955 2827 2169044
SGTC_2054 5233173 129 µM -0.216786601671644 0.408096870330765 no 2028 0.414187326994202 2955 6889
SGTC_1702 st027038 51 µM -0.217267737064514 0.407910110702665 no 2029 0.413999849318755 2831 5521182
SGTC_1152 3909-8331 15.9 µM -0.217508951343399 0.407816487779657 no 2030 0.413905865908425 2801 16001939
SGTC_2714 st079313 56.9 µM -0.217854037971233 0.407682557852064 no 2031 0.413771419680571 2801 2939799
SGTC_411 enrofloxacin 100 µM -0.219088009423923 0.407203735436395 no 2032 0.413290745489807 2950 71188 A bacterial gyrase inhibitor.
SGTC_2594 a-mangostin 100 µM -0.220482764082853 0.406662690674088 no 2033 0.412747597193279 2963 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2880 9042983 58.44 µM -0.221606296819121 0.406226986152123 no 2034 0.412310190109414 2953 6464714
SGTC_1035 k081-0041 55.2 µM -0.222075261824578 0.406045156450244 no 2035 0.41212764762398 2811 731709
SGTC_1139 k015-0024 46.9 µM -0.223263787948682 0.40558442538019 no 2036 0.411665104488044 2858 2766652
SGTC_1844 rapamycin 4 nM -0.226277570574363 0.404416722912992 no 2037 0.410492771049699 2775 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1510 1123-0200 71.5 µM -0.226287935925357 0.404412708277581 no 2038 0.410488740397764 3004 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2162 5663267 200 µM -0.228823671231757 0.403430888365939 no 2039 0.409502983937348 2936 6456493
SGTC_884 0851-0618 334 µM -0.229142357555332 0.403307538037782 no 2040 0.409379136290011 2956 9642473
SGTC_2606 farnesol 9.78 µM -0.231277511029251 0.402481356917196 no 2041 0.408549608353496 2989 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2252 omeprazole 400 µM -0.232237679091053 0.402109969004181 no 2042 0.408176706979229 2873 4594 A proton pump inhibitor.
SGTC_2151 5563267 85.4165 µM -0.232461551623683 0.402023388986735 no 2043 0.408089773333745 2847 5310824
SGTC_2950 9072895 21.46 µM -0.232913457748372 0.401848634362917 no 2044 0.407914304017598 2941 17332245
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.234067631831115 0.401402397930639 no 2045 0.40746623701332 2787 1241132 A phosphatase inhibitor.
SGTC_100 0086-0128 49.5915 µM -0.234735769811572 0.401144135552991 no 2046 0.407206911500115 2850 93297
SGTC_1309 pyrazolanthrone 13.4 µM -0.234775327992519 0.40112884606777 no 2047 0.407191558991223 2920 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_478 N-arachidonylglycine 10 µM -0.235694984000348 0.400773435973752 no 2048 0.406834681222085 2824 5283389
SGTC_520 3584-0023 682 µM -0.237277023281181 0.400162233654554 no 2049 0.406220942973965 2879 1340790
SGTC_2737 bleomycin 30.5 nM -0.238027590920949 0.399872346058137 no 2050 0.405929847323651 2840 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2693 st077581 40.7 µM -0.238636040899387 0.399637388265902 no 2051 0.405693907891337 2928 25238761
SGTC_1567 st069303 68.4 µM -0.240188393645715 0.39903809973593 no 2052 0.40509210544623 2939 5581319
SGTC_2539 epi(13)torulosol 80 µM -0.240213224393452 0.399028515711131 no 2053 0.405082481099884 2937 6708597
SGTC_2892 9047358 58.44 µM -0.241142623132381 0.398669835721623 no 2054 0.404722289410165 2889 6466771
SGTC_1793 st048256 72.231 µM -0.241282680337208 0.398615791288151 no 2055 0.404668016748084 2808 672022
SGTC_2903 5923464 63.88 µM -0.24463049215983 0.397324538645409 no 2056 0.403371275972019 2927 2876576
SGTC_257 daunorubicin 18.5 µM -0.244830366990932 0.397247482258495 no 2057 0.403293889939973 2944 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2113 5491891 107.031 µM -0.245332696090804 0.397053840441684 no 2058 0.403099418665962 2853 789979
SGTC_3046 9092212 49.47 µM -0.245970851026493 0.396807876003628 no 2059 0.40285239845632 2827 25236637
SGTC_2807 7945238 51.95 µM -0.246139327484509 0.396742946866922 no 2060 0.402787190210067 2945 17148797
SGTC_1733 st037357 54.9 µM -0.246310683873865 0.396676910770124 no 2061 0.402720870069862 2795 1272339 YGL099W LSG1
SGTC_1080 nisoldipine 24.4 µM -0.246681159583302 0.396534149628562 no 2062 0.402577494260182 2800 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1986 st071812 45 µM -0.246816747959993 0.396481904725807 no 2063 0.402525024206689 2862 11838594
SGTC_2371 9071574 200 µM -0.247389906579521 0.396261075836139 no 2064 0.402303242426107 2945 45596039
SGTC_3067 9117431 49.47 µM -0.247705190623128 0.396139616098356 no 2065 0.40218125773834 2883 17150885
SGTC_3042 9091578 49.47 µM -0.24779369170211 0.396105523834907 no 2066 0.402147018020263 2842 25236497
SGTC_2396 5342950 42.78 µM -0.247964987322365 0.396039539830149 no 2067 0.402080748489891 2930 1886677
SGTC_2679 rapamycin 1 nM -0.249863086170321 0.395308581594944 no 2068 0.401346615435638 2934 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_538 2922-0838 53.3 µM -0.251404348360149 0.394715311964495 no 2069 0.400750753071692 3036 777039
SGTC_1888 azatryptophan 97.5 µM -0.25194862915225 0.394505863178163 no 2070 0.400540385529172 2953 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_548 1436-0017 110 µM -0.254182520287956 0.393646542761446 no 2071 0.399677277011899 2988 9677137
SGTC_1440 4100-1550 40 µM -0.25611400683726 0.392903966739383 no 2072 0.398931403357716 2879 742806
SGTC_2636 apigenin dimethyl ether 100 µM -0.25658724903881 0.392722084167429 no 2073 0.398748709663694 2998 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1415 3966-0071 78.1 µM -0.257968257141586 0.392191451295897 no 2074 0.398215702698392 2882 2893185
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.262259721587918 0.390543799815658 no 2075 0.39656060648008 2805 4000243
SGTC_3111 9122088 49.47 µM -0.262901613022472 0.39029752212085 no 2076 0.396313206511805 2915 16876704
SGTC_967 1306-0166 352 µM -0.263470319884448 0.390079360287634 no 2077 0.396094048464199 3026 4437607
SGTC_2790 5423970 71.43 µM -0.264776662899814 0.389578364784734 no 2078 0.395590757876511 3057 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3079 9117512 49.47 µM -0.265061918867629 0.389468990665376 no 2079 0.395480881349 2857 7185044
SGTC_726 3448-4391 34.2 µM -0.266820202429064 0.388795015319469 no 2080 0.394803799350336 3053 1356692
SGTC_1721 st082152 9.2685 µM -0.267186774802322 0.388654544942693 no 2081 0.394662679151204 2818 5296051
SGTC_1322 1348-1070 12 µM -0.269573222682734 0.387740415805251 no 2082 0.393744301554355 2911 6758089
SGTC_2381 9035592 200 µM -0.269573567193711 0.387740283885054 no 2083 0.393744169018593 2940 4749657
SGTC_634 1611-4317 11.2 µM -0.270735799097154 0.38729531571622 no 2084 0.393297120501367 2889 2843522
SGTC_1571 st070080 73.4 µM -0.273893390022449 0.386087160145581 no 2085 0.392083275711342 3034 4315245
SGTC_2421 5690543 90.72 µM -0.274081521631334 0.386015212069325 no 2086 0.392010986950338 2986 3397993
SGTC_740 k014-0057 261 µM -0.274599501695996 0.385817138723817 no 2087 0.39181197460601 2988 4012779
SGTC_1401 3807-4679 7.6 µM -0.274811288309955 0.385736161005483 no 2088 0.391730612538126 2881 3291456
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.275923134466897 0.385311122585736 no 2089 0.391303552338593 2863 364106
SGTC_854 0422-0053 192 µM -0.277254113694841 0.384802494756801 no 2090 0.390792495416737 2916 3596728
SGTC_3142 9086498 49.47 µM -0.277390119309852 0.384750531958353 no 2091 0.390740283860217 3022 25236367
SGTC_1562 morin hydrate 59.1 µM -0.277715118448331 0.384626369994741 no 2092 0.390615527057231 3075 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_621 3584-0052 32.1 µM -0.277924136348653 0.384546523502602 no 2093 0.390535297700798 2994 2273927
SGTC_323 4013-0906 34.3 µM -0.278260202831634 0.384418153715593 no 2094 0.390406311833637 2982 2910086
SGTC_3209 9113616 49.47 µM -0.279347724106272 0.384002832150119 no 2095 0.389988992414387 3100 16649353
SGTC_491 tetrandrine 80.3 µM -0.279573329011359 0.383916690883587 no 2096 0.389902435892421 3000 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3080 9117754 49.47 µM -0.283688193526385 0.382346548967016 no 2097 0.388324671689692 3121 9550191
SGTC_601 0986-0029 62.9 µM -0.283950015807955 0.38224670845935 no 2098 0.388224343091481 2927 24747981
SGTC_326 k292-0812 17.5 µM -0.285897330753243 0.381504386268782 no 2099 0.387478379105123 2994 3579357
SGTC_932 2857-0803 154 µM -0.286790312980267 0.3811641243408 no 2100 0.387136440322705 3141 674898
SGTC_3037 9091026 49.47 µM -0.288082744736219 0.380671818906529 no 2101 0.386641700344084 3010 25236398 YIL048W NEO1
SGTC_2251 lansoprazole 556 µM -0.288364191076593 0.380564637621076 no 2102 0.3865339877096 2890 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3197 9113331 49.47 µM -0.288477890274828 0.380521340932077 no 2103 0.386490476244578 3145 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2294 7971431 200 µM -0.28864302771539 0.380458459210343 no 2104 0.386427282457109 3044 5741572
SGTC_1723 st034307 2.5525 µM -0.288913968964862 0.380355295917151 no 2105 0.386323606839923 2995 867466
SGTC_387 norethindrone acetate 66.7 µM -0.290029926143 0.379930475064407 no 2106 0.385896671665056 2956 541197
SGTC_3155 9099265 49.47 µM -0.29150379837898 0.379369625707771 no 2107 0.38533301963653 3023 25236499
SGTC_2235 salicylic acid 500 µM -0.291949216696377 0.379200181535709 no 2108 0.385162726180409 2927 338 A COX inhibitor and kinase inhibitor.
SGTC_2141 5621638 7.665 µM -0.291977327240766 0.379189488618211 no 2109 0.385151979628594 3042 2856238
SGTC_169 k015-0017 16.025 µM -0.292660202795008 0.3789297592755 no 2110 0.384890946074924 3144 1840002
SGTC_1691 st019933 84.6 µM -0.292663688730135 0.378928433552319 no 2111 0.384889613687623 3007 6176082
SGTC_1751 st044839 27.194 µM -0.2932800877553 0.378694035509856 no 2112 0.384654036243159 2920 5291326
SGTC_3031 9088762 49.47 µM -0.295986854850325 0.377665262434745 no 2113 0.383620060087318 2876 205253
SGTC_486 niguldipine 82 µM -0.296040997891493 0.377644692870066 no 2114 0.383599386047476 2920 1236 A calcium channel blocker.
SGTC_2243 6634756 200 µM -0.296487197836623 0.377475189592057 no 2115 0.383429021181012 3187 885676
SGTC_1922 5578187 25 µM -0.296587863756705 0.377436951693469 no 2116 0.383390588755214 3143 1350412
SGTC_1244 0416-0015 52.5 µM -0.29781324240322 0.376971588663552 no 2117 0.382922853472904 2946 96201
SGTC_2702 st077768 96.8 µM -0.298211454387776 0.376820397809875 no 2118 0.382770889986817 3015 6484119
SGTC_1267 0828-0272 9.49 µM -0.298283874242497 0.376792903881969 no 2119 0.382743255455366 3070 745334
SGTC_2487 5918373 44.05 µM -0.298939827894476 0.3765439019996 no 2120 0.382492978765419 2999 2876279
SGTC_1236 0330-0013 258 µM -0.298995224354685 0.376522875695319 no 2121 0.38247184469664 2971 4617066
SGTC_2111 5486399 200 µM -0.299383072152533 0.376375674282921 no 2122 0.382323888334934 2948 689674
SGTC_2902 5787006 60.46 µM -0.300602733362818 0.375912888680818 no 2123 0.381858723446175 2940 591003
SGTC_3246 9135460 32.98 µM -0.301301732855209 0.375647742212373 no 2124 0.381592209828368 3023 41446951
SGTC_2780 5215298 71.43 µM -0.302051302877138 0.375363478429926 no 2125 0.38130647710996 3088 2834131
SGTC_2583 asiatic acid 100 µM -0.302327950072877 0.37525858099748 no 2126 0.381201036778797 3112 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.302383938198412 0.375237352876224 no 2127 0.381179698735872 2871 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3206 9114350 49.47 µM -0.30240429941267 0.37522963293426 no 2128 0.381171938814555 3064 17087243
SGTC_441 propafenone 146 µM -0.303528662927235 0.374803408849438 no 2129 0.380743503630449 2911 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1847 st056231 15 µM -0.304145002218956 0.374569831589228 no 2130 0.380508711481042 2939 5393180
SGTC_1321 1326-2144 215 µM -0.306195529947268 0.373793064246265 no 2131 0.379727887826648 3062 3513030
SGTC_3039 9090270 49.47 µM -0.306667004086385 0.373614535859999 no 2132 0.379548423643693 3077 17173750
SGTC_1705 st027868 56.3335 µM -0.307866977202443 0.373160276490588 no 2133 0.37909177724674 3019 292948
SGTC_96 0929-0093 37.281 µM -0.309143015953166 0.372677415242559 no 2134 0.378606369345331 2950 6991579
SGTC_3021 9087658 49.47 µM -0.310008346263965 0.372350082461895 no 2135 0.378277304712563 3049 25237042
SGTC_1737 st035557 69.7 µM -0.310493110168862 0.372166748696341 no 2136 0.378092999033367 2911 5716916
SGTC_1211 1056-0033 32.3 µM -0.31053187104653 0.372152090898083 no 2137 0.378078263469336 3098 6741922
SGTC_1016 4226-1401 38 µM -0.310743047296094 0.372072235825042 no 2138 0.377997984575871 2953 2901613
SGTC_3184 9108758 49.47 µM -0.311118049041174 0.371930444653418 no 2139 0.377855440217496 2900 902885
SGTC_2011 4012611 177 µM -0.311486551448516 0.371791127851691 no 2140 0.377715382564488 2933 2049887
SGTC_1948 st076329 66.6 µM -0.31269478554347 0.371334458151506 no 2141 0.377256278793016 2891 24208413
SGTC_1540 guanosine 70.6 µM -0.314199590967357 0.370765948241387 no 2142 0.376684726663588 2935 6802 Guanosine is a purine nucleoside
SGTC_1189 1431-2119 7.28 µM -0.314951397788589 0.370482023980296 no 2143 0.376399278063253 2964 3107275
SGTC_2306 7482397 179.52 µM -0.318902700888761 0.36899095399272 no 2144 0.374900148081625 3136 891448
SGTC_3210 9128157 49.47 µM -0.318990636771716 0.36895779268979 no 2145 0.374866806479715 3055 17590849
SGTC_2753 fluvastatin 17.09 µM -0.319604762281332 0.368726228407288 no 2146 0.374633981907151 3058 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1254 0550-0035 264 µM -0.320442900014203 0.368410274214648 no 2147 0.374316304552316 3112 15121435
SGTC_2912 7964298 10.93 µM -0.322820343052031 0.367514530196836 no 2148 0.373415652826602 3053 2975850
SGTC_2745 rifampicin 24.3 µM -0.32307645905186 0.36741807682496 no 2149 0.373318669012887 3018 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2154 5570129 200 µM -0.326309313925499 0.36620130355742 no 2150 0.372095171035661 3001 673366
SGTC_939 1165-0479 45.3 µM -0.328205148949138 0.365488378641805 no 2151 0.371378277494447 3117 1377347
SGTC_669 0108-0021 26.2 µM -0.328368372639917 0.365427020385052 no 2152 0.371316576690348 3250 17201
SGTC_1122 capsaicin 818.572 nM -0.330337864146765 0.36468693060876 no 2153 0.370572342874204 3117 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_954 1189-0853 2.85 µM -0.330749153887602 0.364532440872223 no 2154 0.370416985222925 2975 2828194
SGTC_469 w7 172 µM -0.333038549660014 0.363672894693991 no 2155 0.369552592060044 3015 45115570 A P450 inhibitor.
SGTC_2703 st077852 53.4 µM -0.333819082227705 0.363380002808669 no 2156 0.369258041543285 3111 6281836
SGTC_3285 9112818 20.8695 µM -0.334444336870073 0.363145435970256 no 2157 0.369022143793572 2972 17017947 YPR165W RHO1
SGTC_1836 st055642 81 µM -0.335557315606068 0.362728024473821 no 2158 0.368602358283657 3011 8571
SGTC_2738 aclarubicin 5.55 µM -0.33576435716688 0.362650393590591 no 2159 0.368524285078309 3053 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1911 st060208 74.3 µM -0.336926521703847 0.362214741219927 no 2160 0.368086145813933 3102 688783
SGTC_235 0330-0087 5 mM -0.337410775097735 0.362033265213408 no 2161 0.367903631533262 3035 46494818 YHR062C RPP1
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.337541087129594 0.361984435522509 no 2162 0.367854522240263 3164 1273210
SGTC_1354 1498-1681 81 µM -0.338162263872283 0.361751703036686 no 2163 0.367620455748816 3091 5754243
SGTC_143 4032-1194 15.74 µM -0.33844597629371 0.36164542324385 no 2164 0.367513566018047 2934 1806963
SGTC_3182 9108849 49.47 µM -0.33937999825162 0.361295610372867 no 2165 0.367161742255498 3106 17133045
SGTC_99 0109-0120 622.8 µM -0.340184961813224 0.360994225864191 no 2166 0.366858621158007 3234 759414
SGTC_227 fluconazole 33.516 µM -0.340217320534844 0.360982112314286 no 2167 0.366846437730284 3040 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1682 st012968 530 nM -0.341540633951165 0.360486846955511 no 2168 0.366348310165699 3002 24207270
SGTC_2250 alverine citrate 130 µM -0.341703951992882 0.360425739491447 no 2169 0.366286848844941 2996 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_892 0929-0076 29 µM -0.34187788940028 0.360360662580522 no 2170 0.366221394920213 3020 5751038
SGTC_2400 5203494 178.7 µM -0.34249498708178 0.360129814408715 no 2171 0.365989207938722 2999 6777674
SGTC_568 1193-0097 7.48 µM -0.342893643941914 0.35998070919858 no 2172 0.365839236808375 3095 3646150
SGTC_2651 TUB2.036 5 µM -0.343838820029114 0.359627280617017 no 2173 0.365483752007139 3175 15992207 YFL037W TUB2
SGTC_3065 9113888 49.47 µM -0.344134957843828 0.359516570832315 no 2174 0.365372397050149 3203 16648368
SGTC_3294 9122953 26.2835 µM -0.344655273706479 0.359322081658244 no 2175 0.365176773233087 2995 16459826
SGTC_1908 st060353 56.5 µM -0.345028023876073 0.359182773554533 no 2176 0.365036651440854 3223 4227716
SGTC_1471 k673-0312 37 µM -0.345292014871253 0.35908412339324 no 2177 0.364937424581412 3056 24099884
SGTC_2992 9074591 71.4286 µM -0.346070522615354 0.358793259434273 no 2178 0.364644857899374 3136 17741321
SGTC_1373 2887-0003 58.5 µM -0.347006773887574 0.358443568202484 no 2179 0.364293114893862 3075 776948
SGTC_2771 fluoxetine 41.05 µM -0.348419798910405 0.357916026049599 no 2180 0.36376246778578 3204 3386 A selective serotonin reuptake inhibitor.
SGTC_1120 ficusin 1.78878 µM -0.350031556813364 0.357314619642873 no 2181 0.363157507500182 3158 6199 A DNA cross-linker.
SGTC_503 tyrphostin 8 294 µM -0.350840941615607 0.357012741793223 no 2182 0.362853840072048 3126 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2386 9075165 157.42 µM -0.351307483474964 0.356838775404029 no 2183 0.362678840652961 3025 16452277
SGTC_2100 5377183 190 µM -0.351355451882127 0.356820890399065 no 2184 0.362660849373309 3094 2844202
SGTC_2537 larixol 68.93 µM -0.352255781438102 0.356485261246895 no 2185 0.362323223394622 3065 6708759
SGTC_1884 5633444 25 µM -0.352555694787543 0.356373482774863 no 2186 0.362210778850482 3183 5724239
SGTC_3348 9149464 3.537 µM -0.35324908994489 0.356115099878786 no 2187 0.361950854286785 3020 1951442
SGTC_2557 derrustone 83.84 µM -0.354037306532823 0.355821463484703 no 2188 0.361655462490493 3153 629853 An antioxidant.
SGTC_641 4092-0595 30 µM -0.354511346189431 0.35564490941735 no 2189 0.361477851219494 3111 786260
SGTC_1953 st076800 12.1 µM -0.355521218479521 0.35526889003996 no 2190 0.361099575893669 3053 297591
SGTC_3007 9078383 71.4286 µM -0.357569077780887 0.354506815737961 no 2191 0.360332911325376 3047 6496995
SGTC_2979 9012552 45.46 µM -0.359714049422299 0.353709226897361 no 2192 0.359530492237644 3146 17100905
SGTC_2360 9040895 200 µM -0.361078660637161 0.353202141974258 no 2193 0.359020322506918 3090 4914414
SGTC_713 1488-1073 324 µM -0.362265422322906 0.352761357101474 no 2194 0.358576847393012 3053 3312542
SGTC_1397 3532-0190 20.1 µM -0.362399035338045 0.35271174316141 no 2195 0.358526930133788 2974 5322280
SGTC_446 go6976 132 µM -0.362781279149379 0.352569820065285 no 2196 0.358384138807894 3162 3501 A protein kinase C inhibitor.
SGTC_525 k781-2675 26.7 µM -0.364255975183989 0.352022473427223 no 2197 0.357833435798285 3120 3651118 YDL195W SEC31
SGTC_1222 0366-0074 1.18 µM -0.365024639619715 0.351737298163669 no 2198 0.357546506832726 3169 286520
SGTC_689 0833-0039 98 µM -0.365025329314057 0.351737042323815 no 2199 0.357546249418036 3086 5374726
SGTC_902 1120-0002 2.07 µM -0.365747030602158 0.351469366412543 no 2200 0.357276924306576 3034 3280475
SGTC_2436 5633522 8.09 µM -0.366550825918137 0.351171328862549 no 2201 0.356977046950106 3224 5724242
SGTC_1463 k081-0032 34.1 µM -0.367676905207607 0.35075394626121 no 2202 0.356557081540799 3107 977755
SGTC_1881 5652484 16 µM -0.367773263903941 0.35071823915436 no 2203 0.35652115313444 3179 2255129
SGTC_1279 0874-0590 65.2 µM -0.368132192713983 0.350585244505415 no 2204 0.356387333761817 3096 3523074
SGTC_845 0330-0138 4.51 µM -0.369185376085437 0.350195111995392 no 2205 0.355994777677848 3114 9039800
SGTC_1529 apigenin 74 µM -0.370263833286533 0.349795781016735 no 2206 0.355592959350435 3292 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_947 3447-0010 211 µM -0.372152346203315 0.349096903042601 no 2207 0.354889712057811 3109 748350
SGTC_3297 9117502 71.43 µM -0.373412945290256 0.348630680309969 no 2208 0.354420563106203 3151 7453720
SGTC_1344 1488-0097 29.1 µM -0.373468882515012 0.348609997654158 no 2209 0.354399750424794 3165 747966
SGTC_438 sphingosine 6.67 µM -0.374819589615486 0.348110713664375 no 2210 0.353897322116764 3030 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_840 0245-0196 390 µM -0.375009855727208 0.348040403611854 no 2211 0.353826568431683 3204 3827528
SGTC_782 0083-0095 30.5 µM -0.375077461858341 0.34801542201481 no 2212 0.353801429159057 3021 3591729 An indicator and reagent.
SGTC_3244 9134489 49.47 µM -0.375646359797818 0.347805230842377 no 2213 0.353589910287237 3128 16584271
SGTC_838 0109-0203 71.4 µM -0.376199375417682 0.347600952547433 no 2214 0.353384339856993 3076 759422
SGTC_2490 carminic acid 95.39 µM -0.376434186969965 0.347514228947664 no 2215 0.353297067166329 3064 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1278 0874-0585 172 µM -0.377142448174369 0.347252693234641 no 2216 0.353033873617359 3136 766306
SGTC_1404 3909-7820 48.3 µM -0.378575659546969 0.346723681739813 no 2217 0.352501499973102 3174 23741373
SGTC_211 3455-0679 143.504 µM -0.378888830841555 0.346608127067061 no 2218 0.352385209316864 3161 748649
SGTC_1822 st052468 42 µM -0.378985276959639 0.346572543027806 no 2219 0.352349398524464 3128 2873678
SGTC_2429 5902844 64.44 µM -0.37967479975832 0.346318181299782 no 2220 0.352093414363061 3193 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2567 aureobasidin a 60 nM -0.379678574872711 0.346316788868423 no 2221 0.352092013042629 3278 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1842 st055362 61.2 µM -0.380050254575328 0.346179706910674 no 2222 0.351954055573353 3077 676032
SGTC_1431 4049-0260 9.09 µM -0.38093481648148 0.345853546125017 no 2223 0.351625808480952 3072 3854841
SGTC_2732 terfenadine 20 µM -0.381311505639498 0.345714685822096 no 2224 0.351486058585686 3081 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_860 0443-0016 25.1 µM -0.382103525090241 0.345422788504962 no 2225 0.351192288605337 3081 5337942
SGTC_1736 st036774 51 µM -0.383011402900887 0.345088304861324 no 2226 0.350855654657897 3296 1272247
SGTC_1596 piperlongumine 63 µM -0.383308799983854 0.344978763042936 no 2227 0.350745407596772 3213 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_825 1988-2224 89.6 µM -0.383343968924313 0.344965809942489 no 2228 0.350732371069233 3077 1180859
SGTC_547 1120-0019 610 nM -0.383463100488914 0.344921933851273 no 2229 0.35068821233235 3064 3676939
SGTC_1190 1486-1332 13 µM -0.384718354921966 0.344459751157989 no 2230 0.350223047354476 3130 4150046
SGTC_2014 4013930 200 µM -0.38604494161229 0.343971556331279 no 2231 0.349731692580369 3183 64556
SGTC_2070 5230947 200 µM -0.386760732183978 0.343708247439957 no 2232 0.349466675176453 3192 2835538
SGTC_3063 1327-0034 4 µM -0.386763717747102 0.343707149336995 no 2233 0.349465569942165 3162 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3196 9111891 49.47 µM -0.386936629296057 0.34364355397544 no 2234 0.349401561491045 3095 18891510
SGTC_1679 SEC14.276 6.7 µM -0.387582187143536 0.343406162534017 no 2235 0.3491626265384 3190 1005053 YMR079W SEC14
SGTC_3154 9100113 49.47 µM -0.388761143141163 0.342972783662018 no 2236 0.348726423693888 3094 25237525
SGTC_1286 0929-0070 131 µM -0.391488524489457 0.341971002887551 no 2237 0.347718084669496 3192 1420408
SGTC_1164 k060-0068 93.7 µM -0.392415912493115 0.341630621516659 no 2238 0.347375465272236 3093 5963676
SGTC_6 0844-0013 19.835 µM -0.398199033168075 0.339510943256842 no 2239 0.345241739291677 3208 1584900
SGTC_1814 st052110 31.539 µM -0.398327811187481 0.339463799878415 no 2240 0.345194281309595 3228 674163
SGTC_65 0798-0905 34.986 µM -0.39892304645729 0.339245927317538 no 2241 0.344974953583599 3462 3602145
SGTC_1448 4255-0083 152 µM -0.399634392059573 0.338985625649758 no 2242 0.344712910719945 3259 5399660
SGTC_698 k064-0052 127 µM -0.400923774712966 0.338513999691158 no 2243 0.344238122640535 3210 5088751
SGTC_2524 avocatin b 10.57 µM -0.403086337361643 0.337723553612882 no 2244 0.343442355600484 3177 6710748
SGTC_534 k292-0788 63.4 µM -0.403452503006633 0.337589785798493 no 2245 0.343307684681899 3272 4146317
SGTC_1899 st063254 59.6 µM -0.404321716273693 0.337272326566242 no 2246 0.342988079140087 3080 3093813
SGTC_1149 3909-7961 23.3 µM -0.40768564669837 0.336044825109137 no 2247 0.341752238229167 3147 735261
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.409337333856118 0.335442761281266 no 2248 0.341146060565436 3240 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1116 jasmonic acid 1.58368 µM -0.414328357606862 0.333626032485367 no 2249 0.339316824356279 3259 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1434 4073-0095 163 µM -0.4146375371145 0.333513619048412 no 2250 0.339203632361501 3239 24133745
SGTC_432 NS 1619 61.3 µM -0.415693232838258 0.33312989524015 no 2251 0.338817246866705 3273 4552 A K+/calcium channel activator.
SGTC_2991 9074669 71.4286 µM -0.415750121513436 0.333109222325258 no 2252 0.338796430375867 3302 17333109
SGTC_927 2425-1185 123 µM -0.417427737745577 0.332499817468215 no 2253 0.338182784902106 3099 730375
SGTC_2626 ethyl orsellinate 100 µM -0.417458485168613 0.332488652393761 no 2254 0.338171541985693 3103 75653 A natural product.
SGTC_3112 9123419 49.47 µM -0.418689701102807 0.332041692668827 no 2255 0.337721461706329 3147 17015854
SGTC_841 0251-0215 91.2 µM -0.419912850759331 0.331597897692806 no 2256 0.337274559795355 3209 3888614
SGTC_1666 st014829 29 µM -0.42010187103652 0.331529336593043 no 2257 0.337205517957264 3128 3858230
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.420515373773634 0.331379371295876 no 2258 0.337054500426822 3298 16725076
SGTC_501 nsc-95397 161 µM -0.420540404141225 0.331370294384243 no 2259 0.337045359795958 3295 262093
SGTC_2718 lomofungin 53.02 µM -0.421950393792931 0.330859141509406 no 2260 0.336530612959702 3279 5351222 A RNA synthesis inhibitor.
SGTC_2227 7312221 64.1025 µM -0.422640841180923 0.330608953739451 no 2261 0.336278662008099 3179 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2810 7959871 45.46 µM -0.422918202029233 0.330508471662986 no 2262 0.336177471034205 3214 2974535
SGTC_828 2074-0507 139 µM -0.422921717791103 0.330507198053854 no 2263 0.336176188437023 3274 X828
SGTC_901 1112-0062 60.1 µM -0.423273404395537 0.330379807062187 no 2264 0.336047898076026 3161 1908457
SGTC_1897 st060201 15 µM -0.423349779817406 0.330352144287374 no 2265 0.336020039912291 3168 611878
SGTC_1412 3909-8563 178 µM -0.425059620932995 0.329733091796286 no 2266 0.335396606300165 3265 23767530
SGTC_1414 3917-0015 5.4 µM -0.426328210997958 0.329274096524305 no 2267 0.334934352017745 3248 6618702
SGTC_2026 5148700 152 µM -0.427473144850806 0.328860062729095 no 2268 0.334517370678158 3128 79838
SGTC_2808 7946468 45.46 µM -0.428943967892277 0.328328488180414 no 2269 0.333982000984436 3202 2970879
SGTC_1025 k007-0731 70 µM -0.42905825616877 0.328287197444369 no 2270 0.333940414946393 3121 6256118
SGTC_798 1287-0182 476 µM -0.43053990287427 0.327752089491292 no 2271 0.333401473379438 3314 1649755
SGTC_2437 5741531 144.16 µM -0.431130012459476 0.327539065310967 no 2272 0.333186919620391 3320 2262990
SGTC_1349 flufenamic acid 69 µM -0.431186927437736 0.32751852248968 no 2273 0.333166229191966 3140 3371 A non-steroidal anti-inflammatory.
SGTC_2181 6316240 54.2555 µM -0.43269976558531 0.326972672155284 no 2274 0.332616450073107 3238 12779990
SGTC_1657 st012939 43.4 µM -0.43313913390556 0.326814212020483 no 2275 0.332456847007183 3286 24207257
SGTC_703 3875-0075 71.8 µM -0.434326666850141 0.326386079330586 no 2276 0.332025620891459 3175 2850814
SGTC_2990 9074105 71.4286 µM -0.436506251477227 0.325600884603819 no 2277 0.331234732262941 3230 6502001
SGTC_2342 7990637 118.86 µM -0.437777220597261 0.325143374998884 no 2278 0.330773892711072 3270 2033102 YER133W GLC7
SGTC_950 1165-0508 94.1 µM -0.43820252928665 0.324990335818424 no 2279 0.330619737627992 3231 6148369
SGTC_3253 9135987 49.47 µM -0.439137552111944 0.324653989609099 no 2280 0.330280935353496 3265 4182430
SGTC_2853 9015042 58.44 µM -0.439427327717107 0.324549780591996 no 2281 0.330175964389229 3062 6457456
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.439692914033586 0.324454282582481 no 2282 0.330079767712515 3390 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2271 7849410 118.62 µM -0.44207561214113 0.323598042555295 no 2283 0.329217245766966 3321 972430
SGTC_2329 6138490 200 µM -0.443723933449187 0.323006251894347 no 2284 0.328621094802324 3325 720019
SGTC_1496 4469-0713 57.4 µM -0.445504732792867 0.32236740132471 no 2285 0.327977520156432 3291 746691
SGTC_309 k408-0051 1.48 µM -0.44575747287968 0.322276774847073 no 2286 0.327886222094439 3258 3640463
SGTC_2566 crystal violet carbinol 226 nM -0.445835486910134 0.322248803037325 no 2287 0.327858042928625 3287 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1395 3486-0190 4.35 µM -0.447295719476576 0.321725424803589 no 2288 0.327330778612838 3353 6748079
SGTC_1343 1487-0095 224 µM -0.448088852601569 0.321441297219907 no 2289 0.327044536403835 3320 4560101 YGL055W OLE1
SGTC_1022 4477-0945 21.3 µM -0.448113757928774 0.321432376964978 no 2290 0.327035549702983 3187 4648966
SGTC_1153 4055-0057 267 µM -0.449124517526248 0.321070443642489 no 2291 0.326670917467615 3197 882706
SGTC_790 1575-0012 79.1 µM -0.449246813920541 0.321026663202986 no 2292 0.326626810174527 3310 378741 YLR208W SEC13
SGTC_1769 st044406 64.4 µM -0.449266761077313 0.321019522629167 no 2293 0.326619616283109 3167 670903
SGTC_1684 st024538 14.6195 µM -0.451219979749807 0.320320641025641 no 2294 0.325915505514293 3203 6732859
SGTC_3212 9128307 49.47 µM -0.451886832355761 0.320082180044967 no 2295 0.325675255464837 3064 27243542
SGTC_2196 6573537 42.6665 µM -0.452253095656107 0.31995123892213 no 2296 0.325543330896035 3326 2903087
SGTC_290 2043-6722 48.1 µM -0.453144048682313 0.319632812029018 no 2297 0.325222509314561 3293 773758 YLR208W SEC13
SGTC_3315 9136395 68.55 µM -0.454981593840206 0.318976492766091 no 2298 0.324561240365759 3381 16876844
SGTC_2315 7733312 200 µM -0.456356759619594 0.318485693264511 no 2299 0.32406672720019 3175 726316
SGTC_1675 st018485 24.5 µM -0.456644035098216 0.318383204224773 no 2300 0.323963461346272 3218 3323024
SGTC_1462 k081-0014 26.5 µM -0.458214402012125 0.317823202435807 no 2301 0.32339920694566 3194 3270634
SGTC_1106 tegaserod maleate 11.7 µM -0.460897677501521 0.316867295244522 no 2302 0.322436009061301 3246 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1885 st057546 99.9 µM -0.460942927661954 0.316851185492307 no 2303 0.322419776098436 3372 702008
SGTC_34 0469-0683 81.75 µM -0.461779524769286 0.316553406656551 no 2304 0.32211971774876 3277 3690923
SGTC_2905 7799065 20.05 µM -0.462145855588742 0.316423052071193 no 2305 0.321988364072727 3342 1296806
SGTC_1289 0976-0073 69.1 µM -0.462727578544969 0.31621609954745 no 2306 0.321779823855455 3308 3391136
SGTC_602 3130-1533 38.1 µM -0.462758453043533 0.316205117309371 no 2307 0.321768757311803 3324 720941
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.463447402146724 0.315960096311516 no 2308 0.321521854030018 3174 23665772 A membrane-active detergent.
SGTC_328 k915-0120 63.5 µM -0.464602803301947 0.315549365657344 no 2309 0.321107962200486 3302 6624543
SGTC_2650 prasterone 100 µM -0.464698305351986 0.315515426057799 no 2310 0.321073761055887 3275 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1877 wortmannin 25 µM -0.465753718018645 0.31514045628928 no 2311 0.320695898344554 3357 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2206 7254556 146.969 µM -0.467104496560714 0.314660825955108 no 2312 0.320212558627537 3258 4398905
SGTC_2589 lobaric acid 100 µM -0.468007629819971 0.314340318430753 no 2313 0.319889566735587 3212 73157 A novel microtubule depolymerizer.
SGTC_874 0599-0792 117 µM -0.469179141945547 0.31392477601895 no 2314 0.319470796607154 3380 765305
SGTC_224 benfluorex 43.875 µM -0.471610754400037 0.313063021714793 no 2315 0.318602324517322 3328 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1275 0867-0008 21.1 µM -0.471619005141083 0.313060099417291 no 2316 0.318599379383698 3171 3422836
SGTC_254 nsc-64875 3.808 µM -0.472324448920816 0.312810284501866 no 2317 0.318347610918896 3361 56993
SGTC_1033 k072-0102 21.3 µM -0.472783824468823 0.312647654569527 no 2318 0.318183707750503 3347 5965931
SGTC_2930 9013230 14.89 µM -0.473331345782442 0.312453866566597 no 2319 0.317988401057513 3324 2995857
SGTC_1846 st056244 14.8 µM -0.474037459655473 0.312204023363967 no 2320 0.317736597434057 3273 5393182
SGTC_809 3998-0021 90 µM -0.474077980197663 0.312189688660275 no 2321 0.317722150168441 3334 715485
SGTC_1206 3978-0017 132 µM -0.474738201261948 0.311956166373332 no 2322 0.317486792898032 3446 3873677
SGTC_1833 st055984 71 µM -0.476258436383114 0.311418741809056 no 2323 0.316945136226415 3241 676288
SGTC_2122 5258151 111.688 µM -0.47634213901674 0.311389163401793 no 2324 0.316915324526633 3243 2173356
SGTC_722 3534-0461 190 µM -0.477208154334253 0.311083206841652 no 2325 0.31660695255066 3282 658262
SGTC_748 act1.228 77.9 µM -0.477291358859933 0.311053818190399 no 2326 0.31657733166992 3259 4421505 YNR035C ARC35
SGTC_357 1325-0123 420 µM -0.478007952025127 0.310800760370349 no 2327 0.316322272611342 3340 1098503
SGTC_3164 9100705 49.47 µM -0.478212807202727 0.310728434220229 no 2328 0.316249373971816 3376 17174235
SGTC_1433 4060-0023 7.6 µM -0.478290499011476 0.310701006270045 no 2329 0.316221728858602 3347 3840627
SGTC_2605 digitonin 300 nM -0.479096655201043 0.31041646680301 no 2330 0.315934934573285 3429 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2349 9023730 187.07 µM -0.480313689628722 0.309987119367151 no 2331 0.315502178047121 3380 4126287
SGTC_3130 9127414 49.47 µM -0.481229832891254 0.309664091628867 no 2332 0.315176580060901 3320 1494646
SGTC_1641 st009299 47.1 µM -0.481592338102061 0.309536314586821 no 2333 0.315047785060674 3329 4046054
SGTC_1961 st076550 68.7 µM -0.481874483927204 0.309436878818135 no 2334 0.314947556621515 3331 1579337
SGTC_1482 3346-2049 8.48 µM -0.482059769683166 0.309371586728509 no 2335 0.314881743806909 3333 3826804
SGTC_3048 9093155 49.47 µM -0.482064926635434 0.309369769577265 no 2336 0.314879912160623 3346 25236002
SGTC_2272 7805186 180 µM -0.484022800917524 0.308680212140619 no 2337 0.31418484375165 3357 2956062 YPR165W RHO1
SGTC_522 1273-0010 11.6 µM -0.484544746900639 0.30849649803348 no 2338 0.313999657853914 3428 5705015
SGTC_975 1335-0046 28.5 µM -0.4861276025315 0.307939659098487 no 2339 0.31343834880579 3256 16486740
SGTC_1028 k015-0029 4.8 µM -0.486176763436217 0.307922371662486 no 2340 0.31342092237295 3269 4588309
SGTC_627 1391-0720 175 µM -0.486334874018255 0.307866774954235 no 2341 0.313364878558825 3299 997839
SGTC_1879 gemcitabine 100 µM -0.486537291346556 0.307795605022701 no 2342 0.313293136083034 3276 60750 A nucleoside analog which inhibits DNA replication.
SGTC_312 4092-0653 6.84 µM -0.486948467835435 0.307651057635836 no 2343 0.31314742515972 3330 1148278
SGTC_2730 imipramine 71.33 µM -0.48735536683107 0.307508043374084 no 2344 0.313003258793609 3367 3696 A tricyclic antidepressant.
SGTC_49 0717-0965 32.132 µM -0.488691290644396 0.307038707187106 no 2345 0.312530135341779 3496 5889349 YGL099W LSG1
SGTC_338 4055-0136 114 µM -0.490153789432894 0.306525265043634 no 2346 0.312012538863924 3255 2900563
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.490295344512318 0.306475589171187 no 2347 0.311962460437836 3366 229346 A bile salt which induces apoptosis.
SGTC_598 3937-0236 20.2 µM -0.490602473660792 0.306367820679394 no 2348 0.311853818257194 3337 1379313
SGTC_974 1326-0144 138 µM -0.491584913618423 0.306023205001413 no 2349 0.31150640529735 3280 5411856
SGTC_589 1227-0070 34.1 µM -0.492001304114005 0.305877197262773 no 2350 0.311359210812046 3371 2841384
SGTC_855 0428-0020 25 µM -0.492137958201433 0.305829286093752 no 2351 0.311310910016626 3282 6812414
SGTC_1258 0671-0043 57.1 µM -0.49342652126607 0.305377677047911 no 2352 0.310855623367058 3306 4298767
SGTC_1225 1216-0074 20.6 µM -0.493852138325217 0.3052285739464 no 2353 0.310705304083808 3276 4241466
SGTC_1957 st077035 62.4 µM -0.49397043154426 0.305187138944386 no 2354 0.310663530935966 3386 705593
SGTC_2750 bromebric acid 70.15 µM -0.49425927251272 0.305085976044806 no 2355 0.310561542138837 3381 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2427 5545055 42.75 µM -0.494433353221362 0.305025013667703 no 2356 0.310500081843518 3281 5372858
SGTC_229 benomyl 22.8748 µM -0.495716834584383 0.304575710648165 no 2357 0.310047103996956 3342 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1109 tnp00067 928.257 nM -0.496067888700192 0.304452869878962 no 2358 0.309923256959723 3312 676295
SGTC_1716 st033144 30.6155 µM -0.496620203375311 0.304259648714229 no 2359 0.309728451640157 3431 674617
SGTC_3311 9131146 2.8755 µM -0.497090810900467 0.304095054997423 no 2360 0.309562507167707 3308 4900406 YPR165W RHO1
SGTC_1090 efavirenz 20.7 µM -0.497101699615086 0.304091247168474 no 2361 0.309558668075171 3321 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2889 9059656 51.95 µM -0.498118913830714 0.303735616873869 no 2362 0.309200115094154 3338 3949838
SGTC_2215 7188065 200 µM -0.498263300964253 0.303685152445131 no 2363 0.309149235476926 3377 940217
SGTC_1525 8-methoxypsoralen 92.5 µM -0.499050286609781 0.303410160640854 no 2364 0.30887197923015 3459 4114 Related to psoralen; DNA damaging agent.
SGTC_1451 4152-0210 104 µM -0.49906774011263 0.303404063226388 no 2365 0.308865831567933 3405 659563
SGTC_1710 st031758 61.5 µM -0.499496217085875 0.303254391153651 no 2366 0.308714925554939 3425 5394341
SGTC_555 4296-0685 37 µM -0.501155236675254 0.302675187590324 no 2367 0.308130937480349 3335 2908540 YHR072W ERG7
SGTC_1233 0325-0408 14.2 µM -0.501442115031584 0.302575081752352 no 2368 0.308030003205253 3377 12874
SGTC_158 k038-0087 26.446 µM -0.50196737286538 0.302391832167477 no 2369 0.307845235962222 3240 X158
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.502165659726247 0.302322667685643 no 2370 0.307775498277175 3302 65057 A dermal irritant. YDR527W RBA50
SGTC_2856 9022925 19.48 µM -0.503117649886868 0.301990702673099 no 2371 0.307440779127423 3371 4944862
SGTC_1920 st075728 45.7 µM -0.504019600000754 0.301676338074223 no 2372 0.307123801887199 3422 3400306
SGTC_3258 9138477 49.47 µM -0.504884800712703 0.301374920430838 no 2373 0.306819875067039 3351 4970355
SGTC_1461 k072-0203 53.8 µM -0.505212555388455 0.301260773046848 no 2374 0.306704776396103 3300 5418714
SGTC_2284 7945075 39.21 µM -0.506030656663926 0.300975937255541 no 2375 0.306417564292606 3373 1245402
SGTC_2974 9094440 9.66 µM -0.50627773111456 0.300889937985915 no 2376 0.30633084684179 3417 25236134
SGTC_354 2783-3500 4.88 µM -0.5071710483174 0.300579093342579 no 2377 0.306017403578088 3271 6740761
SGTC_1609 st001574 46.4 µM -0.508524647054696 0.300108362566371 no 2378 0.305542729342972 3285 3960012
SGTC_777 1315-0167 517 µM -0.509412608956372 0.29979974400895 no 2379 0.305231520020352 3334 4221767
SGTC_2923 7992654 58.14 µM -0.509768197952857 0.299676196399671 no 2380 0.305106934071133 3322 2985126
SGTC_3267 9137951 49.47 µM -0.510507544184643 0.299419388130727 no 2381 0.304847965307331 3256 16643986
SGTC_3291 9121177 71.43 µM -0.511074870453959 0.299222397836897 no 2382 0.304649315761244 3302 17015612
SGTC_1998 st075797 76.8 µM -0.511101478797715 0.299213160178482 no 2383 0.304640000251297 3407 24208315
SGTC_667 1498-1044 59 µM -0.513484614647329 0.298386328754305 no 2384 0.303806185136668 3335 6739982
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.518119748513754 0.296781150077873 no 2385 0.302187361160864 3431 551469
SGTC_2493 resveratrol 26.09 µM -0.518303190478968 0.296717704259753 no 2386 0.302123373628741 3377 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2989 9073649 71.4286 µM -0.519204383129433 0.296406105157528 no 2387 0.301809111403493 3421 21367202
SGTC_334 1502-1024 68.5 µM -0.519421786024854 0.296330957736899 no 2388 0.301733321073 3404 3296216
SGTC_3121 9125696 49.47 µM -0.519857101187408 0.296180513090734 no 2389 0.301581588563336 3389 1235365
SGTC_359 0081-0058 15.9 µM -0.520495328913489 0.295960005360038 no 2390 0.301359191365163 3588 3494159
SGTC_2121 5257820 149.641 µM -0.522124907315411 0.295397328097338 no 2391 0.300791682779699 3433 791256
SGTC_603 3794-0023 45.9 µM -0.522135030914231 0.295393834057719 no 2392 0.300788158694694 3393 3802260
SGTC_3318 9139014 38.6185 µM -0.523630048159942 0.294878055518111 no 2393 0.300267938930677 3368 16643984
SGTC_370 0180-0345 38.7 µM -0.52420129909834 0.294681084526639 no 2394 0.300069268718392 3294 3989527
SGTC_1238 0333-0287 48.8 µM -0.524814449105753 0.294469734015589 no 2395 0.299856092995278 3340 7226
SGTC_1557 sumaresinolic acid 42.3 µM -0.525801133977598 0.294129774401338 no 2396 0.299513193286844 3336 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2287 7945887 168.79 µM -0.526256432547402 0.293972963685503 no 2397 0.299355024660184 3367 1245853
SGTC_2456 5770359 74.46 µM -0.526462479193656 0.293902011263105 no 2398 0.299283457457324 3434 3118787
SGTC_1605 st000082 49.1 µM -0.528034917796724 0.293360801087897 no 2399 0.298737550397564 3415 1114022
SGTC_1915 st067105 30.6 µM -0.530670844549178 0.292454591406963 no 2400 0.297823446599285 3423 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_766 1391-0721 126 µM -0.53161550252215 0.292130142889476 no 2401 0.297496162750547 3425 1020919 YIL115C NUP159
SGTC_3071 9117417 49.47 µM -0.532922371938324 0.291681567022918 no 2402 0.297043658976952 3298 45595590 YGL055W OLE1
SGTC_3008 9078912 71.4286 µM -0.533362163538381 0.29153068316528 no 2403 0.296891451875857 3361 16648731
SGTC_2240 6690706 185.951 µM -0.533816803388206 0.291374743438609 no 2404 0.296734143483865 3275 805876
SGTC_1946 st076057 65.1 µM -0.535501629417164 0.290797194207414 no 2405 0.296151515582769 3339 953009
SGTC_591 4299-0174 154 µM -0.542620548544424 0.288362795636561 no 2406 0.29369554398477 3344 5509088
SGTC_3188 9110789 49.47 µM -0.542765751565673 0.288313241891195 no 2407 0.293645548312439 3482 849217
SGTC_3255 9139072 49.47 µM -0.545084930568401 0.287522315504853 no 2408 0.292847553222431 3444 17646060
SGTC_2667 digitoxin 100 µM -0.545746409275504 0.287296914815773 no 2409 0.292620132860032 3399 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2128 5255449 168.493 µM -0.545756312805988 0.287293540795892 no 2410 0.292616728590117 3387 736008
SGTC_2471 5466956 24.79 µM -0.546327633241005 0.287098930187654 no 2411 0.292420372308291 3333 724419
SGTC_1012 4112-3522 18 µM -0.547464197467759 0.286711964590703 no 2412 0.292029930471616 3461 3112398
SGTC_652 0437-0092 114 µM -0.549639528942851 0.285972020659324 no 2413 0.291283320374966 3431 3091274
SGTC_2333 9017922 200 µM -0.549715124811777 0.285946322880963 no 2414 0.291257390636259 3455 3163164
SGTC_1674 st016616 23.6 µM -0.551839678731166 0.28522455924206 no 2415 0.29052909970322 3358 625830
SGTC_2756 carbadox 75.1 µM -0.552157224196626 0.285116755791517 no 2416 0.290420319286478 3383 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.553901568216187 0.284524915415074 no 2417 0.289823105908732 3451 5377381
SGTC_1632 st005650 90 µM -0.554464675553232 0.284333983477477 no 2418 0.289630437185674 3416 2759605
SGTC_2949 9072542 2.23 µM -0.554652010459864 0.28427047769629 no 2419 0.289566353363527 3439 16457352
SGTC_40 0327-0103 19.753 µM -0.554834926575309 0.284208476410616 no 2420 0.289503787553068 3349 409036
SGTC_1574 spiramycin 23.7 µM -0.555226474746595 0.284075778896125 no 2421 0.289369881230016 3413 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2068 5226020 147 µM -0.555430677762929 0.284006585295076 no 2422 0.289300056989914 3402 1810509
SGTC_1140 3229-1848 2.98 µM -0.555796958618347 0.28388249229507 no 2423 0.289174832441993 3461 2849525
SGTC_2103 5378138 10 µM -0.556145512669888 0.283764429097435 no 2424 0.289055692025059 3504 244142
SGTC_1304 1165-0502 251 µM -0.556655746949427 0.283591643534592 no 2425 0.288881328800522 3378 767425
SGTC_1127 asiatic acid 681.4 nM -0.556691760008786 0.283579449989123 no 2426 0.288869023867194 3353 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_650 1328-0195 38 µM -0.556728213365168 0.283567107620737 no 2427 0.288856568744519 3446 2780821
SGTC_467 ro 31-8220 72.8 µM -0.556943498909677 0.283494221543509 no 2428 0.288783016670818 3359 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2649 anisomycin 9.56 µM -0.557993670793965 0.283138808994279 no 2429 0.288424353052591 3439 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_951 1171-0579 82.7 µM -0.55824602318749 0.283053436553196 no 2430 0.288338198820982 3452 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2323 6148992 148.28 µM -0.559800933976501 0.282527672993514 no 2431 0.287807613261814 3355 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1300 1094-0077 113 µM -0.560118845281659 0.282420235164688 no 2432 0.287699188515044 3410 5532636
SGTC_3178 9107506 49.47 µM -0.560637488504929 0.282245002361721 no 2433 0.287522344896705 3481 8897194
SGTC_2092 5303694 80.6725 µM -0.561661831964006 0.281899063577874 no 2434 0.287173221956325 3397 1963699
SGTC_2069 5228469 200 µM -0.562069629858568 0.281761399938515 no 2435 0.287034289678089 3433 2835210
SGTC_1341 1486-1360 280 µM -0.563740520594308 0.281197682458919 no 2436 0.286465368178027 3364 3976547
SGTC_2450 5739737 12.93 µM -0.563929418189872 0.281133987334067 no 2437 0.286401084126051 3465 2262825
SGTC_2835 9006588 71.43 µM -0.564078211816514 0.281083819931639 no 2438 0.286350452742907 3508 2345538
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.564279048479645 0.281016112507882 no 2439 0.286282118933405 3424 77254
SGTC_2155 5570423 76 µM -0.564552282430934 0.280924010672987 no 2440 0.286189164692797 3369 797402
SGTC_1777 st045864 34.765 µM -0.566825211598852 0.280158416615013 no 2441 0.285416469926105 3485 4691462
SGTC_2555 cholic acid 100 µM -0.567382026490683 0.27997101812857 no 2442 0.285227329250283 3507 6708657 Influences liver metabolism.
SGTC_3043 9092303 49.47 µM -0.567734717317446 0.279852349937083 no 2443 0.285107556998363 3410 25236084
SGTC_977 1348-1378 135 µM -0.568068552339841 0.279740048547402 no 2444 0.2849942101858 3430 X977
SGTC_600 1495-0418 41.6 µM -0.569396427259696 0.279293570848497 no 2445 0.284543570438712 3431 5377768
SGTC_2194 5927483 104.545 µM -0.569936513210486 0.279112074291755 no 2446 0.284360379349762 3470 760979
SGTC_1008 4106-0037 6 µM -0.570632333140899 0.27887832770194 no 2447 0.284124448159055 3459 2905394
SGTC_1819 st053448 58.6 µM -0.57095162021698 0.278771101575867 no 2448 0.28401621905147 3397 2857616
SGTC_1144 3486-0183 12.5 µM -0.571100700022841 0.278721043002379 no 2449 0.2839656920538 3431 6744069
SGTC_935 2996-0153 430 µM -0.571387854115034 0.278624633663853 no 2450 0.283868380236823 3492 23738523
SGTC_1774 st048371 48.465 µM -0.572297521773626 0.278319328386584 no 2451 0.283560214194495 3387 4242727
SGTC_156 3474-0145 5.642 µM -0.575056629693297 0.277394307301476 no 2452 0.28262649919743 3466 2265471
SGTC_2793 7325131 81.82 µM -0.575250208356727 0.277329464409168 no 2453 0.282561045387808 3403 4176441
SGTC_2492 derrusnin 100 µM -0.575742995825178 0.277164429238146 no 2454 0.28239445446003 3436 1715307 Part of coumarin class of compounds.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.575924763914783 0.27710356699901 no 2455 0.282333018165362 3505 688798
SGTC_1154 4088-0362 150 µM -0.578196248937477 0.276343547319963 no 2456 0.2815658154975 3485 6618304
SGTC_982 1491-0518 27.5 µM -0.578761373109268 0.27615462052434 no 2457 0.281375098990172 3396 3091256
SGTC_2963 9082507 9 µM -0.578824303366406 0.276133586218875 no 2458 0.281353865323439 3486 16459611
SGTC_2405 ticlatone 3.52 µM -0.579138855697849 0.276028459558499 no 2459 0.281247741974446 3299 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2150 5556613 200 µM -0.579526816267631 0.275898826175243 no 2460 0.281116878852619 3447 743190
SGTC_3156 9099931 49.47 µM -0.579928956634748 0.275764486320616 no 2461 0.280981263789978 3430 18111053
SGTC_894 0960-0238 55.9 µM -0.582533161409517 0.274895299191076 no 2462 0.280103805741254 3495 6741907 YDL195W SEC31
SGTC_2223 6903751 107.57 µM -0.582962295204346 0.274752199896529 no 2463 0.279959341393225 3462 5598863
SGTC_1483 3453-0561 55.9 µM -0.584417080315514 0.274267359571792 no 2464 0.27946986900041 3489 4546991
SGTC_2020 4017018 200 µM -0.584859807744144 0.274119894450155 no 2465 0.279320992857932 3483 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2109 5483026 200 µM -0.584931712548014 0.274095947857373 no 2466 0.279296817036551 3469 759335
SGTC_2898 9056270 58.44 µM -0.58549801612322 0.273907386838799 no 2467 0.279106450086493 3441 19154699
SGTC_2184 6075246 200 µM -0.586279343223673 0.273647335165488 no 2468 0.278843905069045 3477 2267320
SGTC_2236 dapsone 200 µM -0.58806942304669 0.273051997914444 no 2469 0.278242847936245 3506 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1754 st042065 16.137 µM -0.589324596734199 0.272634940762342 no 2470 0.27782177394156 3488 1126236 YIL048W NEO1
SGTC_514 4466-0038 2.65 nM -0.589365014634337 0.272621516343859 no 2471 0.277808220092421 3473 5722064
SGTC_1261 0712-0010 12.7 µM -0.591416669342016 0.271940510220531 no 2472 0.277120637057435 3544 2840123
SGTC_1318 1280-3875 124 µM -0.591467253571131 0.271923730482589 no 2473 0.277103694993496 3491 373245
SGTC_1909 st060837 51.5 µM -0.592396149210269 0.271615689966944 no 2474 0.276792672178496 3421 678937
SGTC_2971 9092186 9.93 µM -0.5932901385644 0.271319389248765 no 2475 0.276493498635749 3386 25236400
SGTC_400 oxethazaine 37.5 µM -0.593803717239698 0.271149243404528 no 2476 0.276321701263621 3476 4621 A local anesthetic.
SGTC_419 nsc-638432 893 µM -0.594653046746249 0.270867981918457 no 2477 0.276037706731537 3456 368090
SGTC_2507 purpurin 79.67 µM -0.594864380462727 0.270798019889586 no 2478 0.275967064299759 3404 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_804 1595-0054 20.9 µM -0.595566693201241 0.270565584068675 no 2479 0.275732366321854 3441 761523 Stimulates phospholipase C.
SGTC_77 0828-0286 12.516 µM -0.597337526270731 0.269979956002432 no 2480 0.275141027474677 3509 745345
SGTC_3286 9117135 37.221 µM -0.599063779269528 0.269409682153235 no 2481 0.274565177124354 3421 3438150
SGTC_3133 9127736 49.47 µM -0.599668742399718 0.26920997341534 no 2482 0.27436351190067 3534 27243420
SGTC_2201 6605497 169.863 µM -0.599703679421852 0.269198442371807 no 2483 0.274351867833855 3494 670741
SGTC_3338 9144300 39.5675 µM -0.599935823645576 0.269121828936715 no 2484 0.274274503302008 3461 4901274
SGTC_2824 7998404 51.95 µM -0.601693446429788 0.268542124419647 no 2485 0.273689106590961 3477 837851
SGTC_1370 2001-0092 44.6 µM -0.602326646703222 0.268333434274369 no 2486 0.273478363425259 3620 790957
SGTC_3279 9140807 49.47 µM -0.602747669883954 0.268194718620554 no 2487 0.273338282002902 3534 45595718
SGTC_278 4092-0821 23.9 µM -0.603233963840104 0.268034542947623 no 2488 0.273176528144531 3510 877900
SGTC_2008 4012253 172 µM -0.603763734441124 0.26786010175096 no 2489 0.273000366833805 3496 603940
SGTC_965 1291-5240 308 µM -0.603979954814243 0.26778892182321 no 2490 0.272928484610178 3529 2834598
SGTC_711 k292-0785 179 µM -0.604786246353385 0.267523574028312 no 2491 0.272660516663432 3550 4146315
SGTC_2761 levamisole 97.89 µM -0.605132768308893 0.267409575581067 no 2492 0.272545391531433 3561 26879 An alkaline phosphatase inhibitor.
SGTC_620 0109-0052 432 µM -0.605160471846788 0.267400462756683 no 2493 0.272536188615549 3549 493037
SGTC_2085 5307070 144.047 µM -0.605204637647484 0.26738593514606 no 2494 0.272521517373505 3475 2840351
SGTC_2485 5633444 17.78 µM -0.605596076106935 0.267257195334445 no 2495 0.272391504304257 3499 5724239
SGTC_905 2-aminofluorene 215 µM -0.606104629305635 0.267089984501675 no 2496 0.272222638563816 3571 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.606332007254431 0.267015240375706 no 2497 0.272147154259382 3513 756377
SGTC_1003 4049-0218 100 µM -0.606367436825243 0.267003594848862 no 2498 0.27213539338515 3576 295161
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.606613878175051 0.266922597879103 no 2499 0.272053593974425 3508 97141
SGTC_2036 5160441 105 µM -0.606739593192999 0.266881284368956 no 2500 0.272011871050233 3531 134534 YIL048W NEO1
SGTC_1041 0206-0046 107 µM -0.607485678690684 0.266636166070891 no 2501 0.271764321991967 3471 50494
SGTC_1546 5-methoxyflavanone 78.7 µM -0.608252552526368 0.2663843366688 no 2502 0.271509992327346 3566 147795
SGTC_1125 tnp00248 1.32998 µM -0.60878712634355 0.266208862179279 no 2503 0.271332773888784 3558 24207736
SGTC_1785 bathophenanthroline 24 µM -0.609795630500471 0.265877978900023 no 2504 0.270998598180449 3465 72812 An iron chelator.
SGTC_551 k048-0028 34.9 µM -0.610117460619267 0.265772432533461 no 2505 0.270892000495396 3547 6836383
SGTC_3266 9136860 49.47 µM -0.610574768834662 0.265622491748681 no 2506 0.270740565286874 3470 4871271 YPR165W RHO1
SGTC_3241 9133421 49.47 µM -0.611242817152728 0.265403531295314 no 2507 0.270519420599385 3534 17018221
SGTC_1097 itavastatin 7.23 µM -0.611465390143633 0.265330600807379 no 2508 0.270445762092364 3540 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1526 st051518 75 µM -0.613358640160991 0.26471065116059 no 2509 0.269819613724447 3426 673993
SGTC_2316 5844804 197.44 µM -0.613449110818293 0.264681044759942 no 2510 0.269789710841997 3552 776813
SGTC_176 1486-1328 72.834 µM -0.614288916141028 0.264406299995192 no 2511 0.269512212773732 3521 22310231
SGTC_3356 9151811 4.48 µM -0.615291976779981 0.264078336115934 no 2512 0.269180957586116 3495 1859254 YPR165W RHO1
SGTC_2334 9017922 200 µM -0.618455376052395 0.263045380397681 no 2513 0.268137602243606 3535 3163164
SGTC_408 cantharidin 100 µM -0.620257821899402 0.262457746367643 no 2514 0.267544029418827 3483 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2622 2-methoxyxanthone 59.94 µM -0.620274834360643 0.262452203162402 no 2515 0.267538430114304 3530 71034 A hepatoprotective.
SGTC_1781 st038725 66.3 µM -0.622354247431079 0.261775115420354 no 2516 0.266854479008711 3528 4270275 YIL048W NEO1
SGTC_2033 5192550 145 µM -0.623928516992894 0.261263106563859 no 2517 0.266337265644593 3504 182073
SGTC_470 aa-861 153 µM -0.624102950620668 0.261206406179145 no 2518 0.266279988139768 3509 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1248 0469-0687 58.6 µM -0.625087044578499 0.260886640804204 no 2519 0.265956965192534 3530 4017482
SGTC_2565 isoliquiritigenin 100 µM -0.627806046821025 0.260004192946136 no 2520 0.265065502211819 3511 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2051 5263410 176 µM -0.628087198564892 0.259913033482471 no 2521 0.264973409342072 3622 227584
SGTC_1047 2043-3044 82 µM -0.628391861813085 0.259814269362127 no 2522 0.264873633501741 3532 669592
SGTC_2765 myclobutanil 7.74 µM -0.629683462338245 0.259395780295834 no 2523 0.264450852347158 3576 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_768 0384-0033 77.3 µM -0.631007390378266 0.258967178541611 no 2524 0.264017846111438 3516 3965305 YMR134W ERG29
SGTC_2086 5274770 176.623 µM -0.631940480775327 0.258665324793972 no 2525 0.263712885122265 3543 689278
SGTC_1312 1218-2183 165 µM -0.632242280406166 0.25856773193469 no 2526 0.263614286722595 3585 6744073
SGTC_1821 st053465 65.6 µM -0.632618634937336 0.2584460569993 no 2527 0.263491357480473 3540 675086
SGTC_2097 5376186 200 µM -0.633769138214065 0.258074284781044 no 2528 0.263115748392727 3550 742755
SGTC_1188 1403-0014 4.57 µM -0.634880132962216 0.257715542692859 no 2529 0.262753297634065 3593 9614867
SGTC_2354 9060492 162 µM -0.635135801693585 0.257633023483085 no 2530 0.262669924469122 3581 6471895
SGTC_2091 4-phenylthiadiazole 200 µM -0.635801374736022 0.257418268612193 no 2531 0.262452945663239 3553 270010
SGTC_146 3448-8650 53.125 µM -0.635895621372249 0.257387866360068 no 2532 0.262422228396035 3570 2891488 YIL048W NEO1
SGTC_3110 9122132 49.47 µM -0.636611864347109 0.257156880375245 no 2533 0.262188847585084 3641 918317
SGTC_268 camptothecin 39.6153 µM -0.637099775700719 0.256999592324326 no 2534 0.262029927330952 3598 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2191 5911152 200 µM -0.640666301401614 0.255851372701857 no 2535 0.26086975644058 3542 2875902
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.643125713690172 0.255061143607416 no 2536 0.260071265382136 3534 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1581 himbacine 57.9 µM -0.643186238994418 0.255041712446336 no 2537 0.260051630686411 3577 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_878 0828-0289 13.7 µM -0.643191058933485 0.255040165077039 no 2538 0.260050067108177 3601 745350 YLR208W SEC13
SGTC_614 0462-0418 107 µM -0.643735872985702 0.254865292336849 no 2539 0.259873361804966 3469 5188303
SGTC_1647 st011722 22.4 µM -0.643883384829237 0.254817955237331 no 2540 0.259825528387049 3589 2854783
SGTC_1199 1638-0010 4.46 µM -0.644777428096436 0.254531151933905 no 2541 0.259535715707325 3553 3111136
SGTC_1270 0831-1170 17.3 µM -0.644888509303084 0.254495529615543 no 2542 0.25949971933326 3582 6764716
SGTC_2023 5144124 124 µM -0.647119791098172 0.253780539741264 no 2543 0.258777208683369 3565 2830192
SGTC_847 0342-0274 5.54 µM -0.647544832830016 0.253644459443061 no 2544 0.258639694198228 3582 18097
SGTC_2145 5634607 200 µM -0.649790061504113 0.252926269042386 no 2545 0.257913919763269 3569 308662
SGTC_3064 1327-0027 10 µM -0.651361407772694 0.252424273484763 no 2546 0.257406608350691 3496 16000455 YPR107C YTH1
SGTC_2874 9043904 71.43 µM -0.652045380401437 0.252205929951179 no 2547 0.257185948870636 3530 4463428
SGTC_2724 maprotiline 69.64 µM -0.652181971252951 0.252162338197346 no 2548 0.257141894467048 3589 4011 A tricyclic antidepressant.
SGTC_1613 st002381 52.1 µM -0.652714119978881 0.25199254557717 no 2549 0.256970298918785 3600 551167
SGTC_324 1315-0088 19.6 µM -0.653700740754575 0.251677904308505 no 2550 0.256652312963369 3563 6787421
SGTC_688 0527-0193 473 µM -0.653978597603577 0.251589330993813 no 2551 0.256562797233919 3592 4007154
SGTC_2047 4141938 200 µM -0.654398486049428 0.25145551306506 no 2552 0.256427554768268 3578 3807862
SGTC_2263 7948595 193.29 µM -0.654778561255438 0.251334416008622 no 2553 0.256305167843645 3588 2971371
SGTC_2513 baicalein 25.65 µM -0.655178109089491 0.251207147959681 no 2554 0.256176543428642 3561 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3006 9075424 71.4286 µM -0.655812745428856 0.251005067204761 no 2555 0.255972307370918 3578 7465181
SGTC_1130 3454-2858 15.9 µM -0.656060117882198 0.25092632223125 no 2556 0.255892722001609 3562 715628 YIL048W NEO1
SGTC_70 0141-0289 43.283 µM -0.656472362430498 0.250795123312228 no 2557 0.255760122209377 3649 352408
SGTC_1388 3346-4487 254 µM -0.657182272911675 0.250569275853214 no 2558 0.255531861309723 3649 3345614
SGTC_2635 hydroquinidine 100 µM -0.657647166846828 0.250421435168729 no 2559 0.255382439433698 3598 442912 An experimental heart treatment.
SGTC_1493 4348-0038 111 µM -0.658171276818494 0.250254818679065 no 2560 0.255214039666376 3639 800424
SGTC_3183 9108214 49.47 µM -0.658570437263105 0.250127963547269 no 2561 0.255085825912505 3528 4974831
SGTC_320 4092-0846 5.34 µM -0.659431806922472 0.24985433234228 no 2562 0.254809261442218 3579 1359356
SGTC_3310 9130229 44.1445 µM -0.659835526049272 0.249726137645794 no 2563 0.254679691273022 3608 7761258
SGTC_138 0850-0259 40.9225 µM -0.660006218637334 0.249671947390898 no 2564 0.254624919339802 3652 6813004
SGTC_2704 st078022 71.1 µM -0.660515569122243 0.249510279595033 no 2565 0.254461515351269 3639 54697681
SGTC_918 glabranin 770.725 nM -0.661144440234864 0.249310752722996 no 2566 0.254259843951849 3634 124049 Also referred to as licorice root.
SGTC_2441 5730946 39.09 µM -0.661403798611938 0.249228488769202 no 2567 0.254176695254832 3629 1774275
SGTC_517 1365-0151 113 µM -0.661709294710111 0.249131609252705 no 2568 0.254078773382562 3652 768657
SGTC_2597 laccaic acid a 100 µM -0.661872119307132 0.249079982184514 no 2569 0.254026590656293 3584 5491415 A textile dye.
SGTC_2855 9016525 58.44 µM -0.663144173088573 0.248676845955683 no 2570 0.253619111031431 3633 43811474
SGTC_1158 4092-0494 91.8 µM -0.663217472561215 0.248653626656457 no 2571 0.253595641325525 3672 1148199
SGTC_2190 6049624 200 µM -0.664547994717699 0.248232353856033 no 2572 0.253169820769917 3559 2265554
SGTC_3053 9095903 49.47 µM -0.66471738843841 0.248178747374963 no 2573 0.253115634970406 3668 17174018
SGTC_3238 9133470 49.47 µM -0.664916584244416 0.248115717600317 no 2574 0.253051923861344 3632 3534688
SGTC_696 1560-0013 611 µM -0.667429481199343 0.247321317577363 no 2575 0.252248919939773 3676 1650269
SGTC_3134 9127454 49.47 µM -0.668145315731843 0.247095270488964 no 2576 0.252020418961734 3704 24262820
SGTC_2700 st077718 96.8 µM -0.668323813283218 0.247038921537387 no 2577 0.251963457915614 3610 904970
SGTC_3272 9137413 49.47 µM -0.66849778704915 0.246984007292165 no 2578 0.251907947010802 3582 17614870
SGTC_1760 st045453 10.4495 µM -0.66887820470932 0.246863952472813 no 2579 0.251786587245589 3639 3323419 YIL048W NEO1
SGTC_781 4335-2806 94.4 µM -0.669323233707554 0.246723546817127 no 2580 0.251644654542888 3692 845254
SGTC_439 amiodarone 34.4 µM -0.670165691775105 0.246457870311671 no 2581 0.251376085904606 3563 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2757 clomiphene 4.22 µM -0.671639901679957 0.245993334434519 no 2582 0.250906484808235 3688 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2813 7971799 71.43 µM -0.672465289975861 0.245733452963688 no 2583 0.250643765014077 3651 2234054
SGTC_1979 st071809 45.3 µM -0.675117846334127 0.244899269049791 no 2584 0.249800448047577 3692 4976333
SGTC_2138 5575593 77.673 µM -0.677206998805865 0.244243340373624 no 2585 0.249137313899925 3633 762213
SGTC_2980 9014342 25.29 µM -0.677280473057224 0.244220289004501 no 2586 0.249114008922738 3646 2996599
SGTC_2607 solasodine 47.35 µM -0.67732683274197 0.244205744999744 no 2587 0.249099304893325 3660 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2364 9055074 200 µM -0.67754850934715 0.244136206858129 no 2588 0.249029001493944 3624 6470630
SGTC_1983 st071813 46.9 µM -0.678401065335415 0.243868866535452 no 2589 0.248758716907795 3650 11838595
SGTC_1435 4092-0789 56.7 µM -0.679067560079773 0.243659980461971 no 2590 0.248547527884522 3652 2248285
SGTC_2686 alizarin 95.37 µM -0.679788465520008 0.243434150341552 no 2591 0.248319205586024 3622 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_201 4262-0159 12.803 µM -0.680086743401725 0.243340745193945 no 2592 0.248224768917753 3609 1341029
SGTC_2245 6637752 200 µM -0.680647960505279 0.243165053649063 no 2593 0.24804713595446 3611 681890
SGTC_2440 5628896 157.78 µM -0.680648357882027 0.243164929272783 no 2594 0.248047010203263 3663 5522048
SGTC_1067 clotrimazole 1.36 µM -0.682246559985667 0.242664981007425 no 2595 0.247541529086934 3672 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2420 aureobasidin a 50 nM -0.682821396138404 0.242485297408265 no 2596 0.24735985393873 3708 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1207 2099-0101 141 µM -0.684902490885734 0.241835387221742 no 2597 0.246702727041102 3670 5837381
SGTC_2274 7947094 46.08 µM -0.685056538869477 0.241787316798866 no 2598 0.246654122005682 3650 2971028
SGTC_2511 berberine 10.47 µM -0.688100508030346 0.240838515567289 no 2599 0.245694745292893 3658 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1291 0993-0025 5.79 µM -0.68827894420048 0.24078296016633 no 2600 0.245638569279181 3670 4353356
SGTC_648 0375-0473 33.3 µM -0.690081332810198 0.240222184707385 no 2601 0.245071520781634 3671 1713139
SGTC_162 k030-0015 37.8 µM -0.690644571984666 0.240047090706692 no 2602 0.244894464914514 3716 1809920 YMR134W ERG29
SGTC_2984 9022109 38.96 µM -0.692500368954892 0.239470672272078 no 2603 0.244311577142321 3705 6459207
SGTC_264 promethazine 12.5 mM -0.693199240917944 0.239253795734584 no 2604 0.244092262245085 3699 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2645 abamectin 100 µM -0.693978009330245 0.239012251905727 no 2605 0.243847999962535 3646 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.696547383003123 0.238216277964055 no 2606 0.243043047150196 3530 88881 An O-methylated flavonoid and antioxidant.
SGTC_2314 7727897 200 µM -0.69680898332921 0.238135317556188 no 2607 0.242961171708724 3668 900724
SGTC_2356 9061756 188.97 µM -0.697051700021739 0.238060214766191 no 2608 0.242885219796679 3649 20104043
SGTC_279 1273-0055 2.93 µM -0.697175074111747 0.238022044625252 no 2609 0.242846617991133 3709 2847562
SGTC_2600 tangeritin 87.95 µM -0.701105413142871 0.236807812546299 no 2610 0.241618616201288 3648 68077 A bioactive flavone.
SGTC_1068 loratadine 26.9 µM -0.701606535933887 0.236653241750637 no 2611 0.24146228723849 3684 3957 A H1 histamine antagonist.
SGTC_1971 st069429 63.5 µM -0.701910055365568 0.236559648498085 no 2612 0.241367628826742 3687 1246522 YGL099W LSG1
SGTC_1719 st032227 49.2 µM -0.702166221690479 0.236480672901263 no 2613 0.241287754088817 3704 3125804
SGTC_1524 corynanthine 62.1 µM -0.70252458055462 0.236370215889707 no 2614 0.241176038994347 3735 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_163 TUB2.036 7.546 µM -0.702820500096282 0.236279025976005 no 2615 0.241083809985177 3724 15992207 YJR013W GPI14
SGTC_283 0987-0079 11.7 µM -0.703922782139079 0.235939519708979 no 2616 0.24074043142841 3707 411556
SGTC_1812 st052057 4.327 µM -0.705025884754962 0.235600030043112 no 2617 0.240397063878893 3690 3645418
SGTC_2691 st077356 60.2 µM -0.706036935241719 0.23528910706253 no 2618 0.240082584245494 3727 2839272
SGTC_907 3448-6986 75.5 µM -0.706077653068303 0.235276590072873 no 2619 0.2400699239721 3715 590582
SGTC_2172 5754775 163.918 µM -0.706178477524948 0.235245597400624 no 2620 0.240038576488499 3631 2263357
SGTC_1183 1254-0324 198 µM -0.706410157418791 0.235174389302643 no 2621 0.239966553000702 3711 5799357
SGTC_3185 9108267 49.47 µM -0.706870255440983 0.23503301092718 no 2622 0.239823554974095 3653 4910486
SGTC_983 1491-0821 12.2 µM -0.709811583259847 0.234130313637359 no 2623 0.238910492545565 3660 46495113
SGTC_680 0417-1641 114 µM -0.709815769018377 0.234129030392146 no 2624 0.238909194536403 3676 2835990
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.712474552715034 0.233314703533291 no 2625 0.238085481970224 3748 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_676 falcarinol 140 µM -0.712525420964915 0.233299139046958 no 2626 0.238069737766097 3725 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1914 st062367 72.6 µM -0.715472827341983 0.232398286672196 no 2627 0.237158462706568 3706 978205
SGTC_1348 1493-0373 93.8 µM -0.71698535389483 0.231936746695228 no 2628 0.236691566904623 3691 3010129
SGTC_811 0416-0114 265 µM -0.718226543167913 0.231558385561131 no 2629 0.236308807128068 3722 6612453
SGTC_1295 1013-0063 9.78 µM -0.718743967289988 0.231400756912711 no 2630 0.236149343825026 3711 6826038
SGTC_827 3253-0474 693 µM -0.72144466807104 0.23057898445725 no 2631 0.235317986269131 3707 5402065
SGTC_1883 5-benzylidenerhodanine 20 µM -0.721676817490578 0.230508421953038 no 2632 0.235246599130132 3706 1273210
SGTC_1607 st000305 50.6 µM -0.722273812573259 0.230327018965702 no 2633 0.235063074999933 3703 5457690
SGTC_1673 st016611 27.3 µM -0.723003529922024 0.230105395438248 no 2634 0.234838857761282 3723 5226799
SGTC_2701 st077767 14.721 µM -0.723616251662601 0.229919397006747 no 2635 0.23465068061952 3717 5721188
SGTC_1895 st058434 18.3 µM -0.724722080564359 0.229583923567008 no 2636 0.234311273129129 3715 5393175
SGTC_784 4579-0127 173 µM -0.724970915474276 0.229508472756019 no 2637 0.234234936727742 3826 1948547
SGTC_2529 gangaleoidin 93.61 µM -0.728280254011999 0.228506349404225 no 2638 0.233221023615802 3764 4565183
SGTC_1854 st056233 32.9 µM -0.730928172985143 0.227706288443077 no 2639 0.23241151331874 3654 5393174
SGTC_1770 st043884 66.3 µM -0.730972280797396 0.227692974762063 no 2640 0.232398042116157 3717 670149
SGTC_2839 9003951 25.97 µM -0.732090439729754 0.227355611525773 no 2641 0.232056684321496 3706 2990634
SGTC_2401 5128683 200 µM -0.732355322948474 0.227275734057909 no 2642 0.231975860209545 3695 708373
SGTC_2920 7982904 15.77 µM -0.733183962402765 0.227025953926965 no 2643 0.231723117775466 3722 6456808
SGTC_2073 5212005 126 µM -0.733422947351699 0.226953944499372 no 2644 0.231650253748351 3590 691789
SGTC_812 4251-0442 148 µM -0.734343633675257 0.226676649575606 no 2645 0.231369665438866 3708 5723007
SGTC_1445 4239-0156 97.7 µM -0.735424210821443 0.226351442314763 no 2646 0.23104059072236 3804 4008346
SGTC_233 rapamycin 362 pM -0.735730202596687 0.226259399847065 no 2647 0.23094745267481 3728 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1924 st058459 75.1 µM -0.735825275383516 0.226230806214841 no 2648 0.230918518604582 3687 688683
SGTC_2720 fluspirilene 36.88 µM -0.736132881875638 0.226138305962088 no 2649 0.230824916749173 3709 3396 An atypical antipsychotic.
SGTC_3274 9138298 49.47 µM -0.736461167823656 0.226039610777913 no 2650 0.230725045701389 3706 17015756
SGTC_385 1494-0393 12.4 µM -0.737255440074795 0.225800923216388 no 2651 0.230483512326276 3754 3090647
SGTC_873 0591-4978 488 µM -0.73744403726505 0.225744268633464 no 2652 0.230426181834794 3768 3305145
SGTC_1744 st037937 38.9 µM -0.739870384274247 0.225016111723062 no 2653 0.229689323072835 3774 1016152
SGTC_835 0312-0010 67.2 µM -0.741380274213343 0.224563660107837 no 2654 0.229231450681438 3701 1626196
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.742160503842238 0.224330059952955 no 2655 0.228995047658522 3737 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_701 4424-0219 185 µM -0.743363275359181 0.2239702214531 no 2656 0.228630886104953 3753 2911779
SGTC_1898 st060199 18.6 µM -0.743594255998338 0.223901155505507 no 2657 0.228560989643699 3747 688866
SGTC_1896 st058441 89 µM -0.744273209034402 0.223698210594337 no 2658 0.228355602907925 3771 688759
SGTC_2518 prenyletin 46.28 µM -0.744276754768721 0.223697151018398 no 2659 0.228354530577633 3692 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2545 solidagenone 89.61 µM -0.746157075525124 0.223135654698863 no 2660 0.227786267240862 3567 6708572 An anti ulcer agent
SGTC_2060 5238662 140 µM -0.747396530612138 0.22276597118998 no 2661 0.227412119496526 3733 790130
SGTC_3192 9110362 49.47 µM -0.748259549707614 0.22250877083987 no 2662 0.227151809066099 3797 16649480
SGTC_2845 9003024 42.97 µM -0.748333121089766 0.222486852642638 no 2663 0.22712962567446 3757 2990173
SGTC_1484 3473-2379 286 µM -0.749915337278453 0.222015780914508 no 2664 0.226652848300853 3861 671917
SGTC_1175 0741-0056 27.6 µM -0.750366551218813 0.221881545840063 no 2665 0.226516985257949 3818 765927
SGTC_1467 k284-1082 293 µM -0.750416846744625 0.221866585912583 no 2666 0.226501843842431 3723 3334705
SGTC_2283 7944793 200 µM -0.75216451639802 0.221347116045799 no 2667 0.225976064764731 3780 2970533
SGTC_2455 5377712 9.75 µM -0.75228142817668 0.221312390525987 no 2668 0.225940916987191 3758 2243908
SGTC_3313 9133968 57.047 µM -0.753976916439246 0.220809141395109 no 2669 0.225431541378634 3744 1494643
SGTC_943 3253-1379 105 µM -0.754515182625484 0.220649512175325 no 2670 0.225269966106123 3746 668464
SGTC_468 gf-109203x 121 µM -0.754932327169818 0.220525848494197 no 2671 0.225144793919626 3714 2396 A protein kinase C inhibitor.
SGTC_1776 st049249 45.9 µM -0.756521960049472 0.220054961518577 no 2672 0.224668155563967 3809 1822314
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.756949440658609 0.219928430103561 no 2673 0.224540076734182 3770 688761
SGTC_2025 5147754 141 µM -0.758235826879294 0.219547920296353 no 2674 0.224154908456037 3765 315777 YLR208W SEC13
SGTC_3047 9092122 49.47 µM -0.758409217946427 0.219496660590082 no 2675 0.224103020614827 3753 17173831
SGTC_3005 9076496 71.4286 µM -0.761085334597861 0.218706390963366 no 2676 0.223303049683833 3792 21368410
SGTC_2884 9058502 51.95 µM -0.761333511637242 0.218633186203758 no 2677 0.223228944615187 3757 6471554
SGTC_1102 cgs 12066b 26.1 µM -0.762018269327277 0.218431276453527 no 2678 0.223024550224316 3780 6438352 A 5-HT1B full agonist.
SGTC_2320 7373003 200 µM -0.764327817434736 0.217751068490304 no 2679 0.222335956121518 3830 5415828
SGTC_2806 7952793 58.44 µM -0.764625357326108 0.217663526000797 no 2680 0.222247332578614 3805 2972490
SGTC_1202 1988-0068 29.6 µM -0.765807120050514 0.217316027138091 no 2681 0.221895538523477 3745 2850480
SGTC_1734 st037168 69.4 µM -0.76593640211971 0.217278031029101 no 2682 0.221857072386721 3843 708907
SGTC_1612 st002233 45.4 µM -0.766198281867961 0.217201076109398 no 2683 0.221779165270327 3790 1035021
SGTC_3145 9085516 49.47 µM -0.766905959388045 0.216993199642009 no 2684 0.221568715102814 3842 25236195
SGTC_3275 9138069 49.47 µM -0.766915704975648 0.216990337730894 no 2685 0.221565817742796 3884 17617007
SGTC_1368 1852-0141 284 µM -0.767846154062977 0.216717200445709 no 2686 0.221289295277723 3763 2838987
SGTC_428 3448-4153 16.5 µM -0.768118803015469 0.216637200871221 no 2687 0.221208303470735 3761 3834874
SGTC_2975 9084847 53.72 µM -0.769334812252569 0.21628061231086 no 2688 0.220847288059436 3854 27211724
SGTC_87 0100-0052 35.5 µM -0.77167911441414 0.215594117408921 no 2689 0.22015225185676 3859 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2885 9057732 51.95 µM -0.772028429118542 0.215491933937706 no 2690 0.220048794906161 3799 6471414
SGTC_1956 st077085 54 µM -0.772661712535899 0.215306754011464 no 2691 0.219861305739765 3832 24208685
SGTC_51 1013-0126 23.419 µM -0.772761430282825 0.215277603722539 no 2692 0.21983179177466 3838 1627850
SGTC_31 0508-1974 57.237 µM -0.773151406443496 0.215163624768997 no 2693 0.219716390400399 3738 6810525
SGTC_588 3970-1144 52.9 µM -0.774208392292694 0.214854874028728 no 2694 0.219403783105838 3734 1888707
SGTC_626 0214-0009 33 µM -0.774994518608282 0.214625409666614 no 2695 0.219171449281495 3838 3437874
SGTC_2800 7887935 81.82 µM -0.77523304051593 0.214555815090397 no 2696 0.219100983872117 3810 2961002
SGTC_2713 st079149 53.4 µM -0.775626887187285 0.214440929449875 no 2697 0.218984660113691 3831 3103253
SGTC_284 0988-0104 32.6 µM -0.777140937651436 0.213999611955646 no 2698 0.218537811795448 3797 4666532
SGTC_1757 st041620 31.8375 µM -0.777361103546905 0.213935481756983 no 2699 0.21847287702568 3866 5289815
SGTC_2731 amoxapine 43.43 µM -0.77835345701599 0.213646566690933 no 2700 0.218180334559456 3848 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_32 0928-0142 34.1 µM -0.778942912384323 0.213475059560699 no 2701 0.218006672023176 3755 2244242
SGTC_897 1000-0139 31.4 µM -0.779281354221274 0.213376623258 no 2702 0.217906997923709 3768 6151020
SGTC_1393 3470-5649 58.2 µM -0.780795973433947 0.212936418351865 no 2703 0.217461251331155 3768 4108395
SGTC_1111 tnp00062 510.699 nM -0.781219101573508 0.212813536285124 no 2704 0.217336820481064 3868 676306
SGTC_2588 indole-3-carbinol 100 µM -0.781576448379765 0.212709790245517 no 2705 0.217231766220949 3836 3712 Induces cell cycle arrest.
SGTC_1227 3909-8010 46.6 µM -0.782124909694231 0.212550616701595 no 2706 0.2170705844134 3796 15982272
SGTC_2188 6126565 140.678 µM -0.783090099920869 0.212270669786708 no 2707 0.216787102193039 3743 874518
SGTC_2849 9019321 12.99 µM -0.786085744271576 0.21140317691335 no 2708 0.2159086277208 3809 16489627
SGTC_2644 guaiazulene 100 µM -0.786926543972771 0.211160067840705 no 2709 0.215662433937611 3828 3515 A coloring agent.
SGTC_3215 9129942 49.47 µM -0.78710875880435 0.211107403798539 no 2710 0.215609101247892 3751 17682944
SGTC_1074 carmofur 3.8 µM -0.787197341385359 0.211081804290571 no 2711 0.215583176663049 3836 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3308 9128332 17.569 µM -0.787441096276863 0.211011370880261 no 2712 0.215511848669478 3807 17332805 YDL196W YDL196W
SGTC_529 4076-0302 30.3 µM -0.788235038366725 0.210782055437412 no 2713 0.215279618829556 3787 5816522
SGTC_1597 7-benzyloxygramine 47.5 µM -0.791674796793614 0.209790234905395 no 2714 0.214275160782182 3792 260807
SGTC_707 0865-0008 204 µM -0.793205731095926 0.209349688824605 no 2715 0.213828984499035 3815 723043
SGTC_564 3555-0129 330 µM -0.793267487855254 0.209331928952415 no 2716 0.21381099743671 3707 563260
SGTC_2642 cholecalciferol 100 µM -0.79402109469581 0.209115279802203 no 2717 0.213591575478048 3790 9821465 A vitamin D precursor, similar to steriods.
SGTC_1320 1313-0481 95.3 µM -0.794419897157885 0.209000684317015 no 2718 0.21347551231197 3805 6813365 YLR208W SEC13
SGTC_2228 7354201 200 µM -0.794655107848444 0.208933114106186 no 2719 0.213407076365994 3839 753451
SGTC_2648 atorvastatin 78.68 µM -0.794988586360767 0.208837336041236 no 2720 0.213310070736462 3811 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_225 nsc-122657 1.016 µM -0.795986072035591 0.208551003534438 no 2721 0.213020065437906 3832 275685
SGTC_3082 9117008 49.47 µM -0.797303000288771 0.208173328416219 no 2722 0.212637539139582 3898 41448529
SGTC_1081 sertraline 6 µM -0.798848442526095 0.207730634074216 no 2723 0.212189148691728 3841 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2291 7917025 104.35 µM -0.800564804926956 0.20723963173787 no 2724 0.211691816335405 3788 2964612
SGTC_531 3788-1495 174 µM -0.801385413258227 0.207005121818983 no 2725 0.211454278521638 3801 2896655
SGTC_1371 2421-0008 32.7 µM -0.801586849840922 0.206947580150991 no 2726 0.211395993446331 3826 2827552
SGTC_592 k241-0073 46.5 µM -0.804717975100538 0.206054371597402 no 2727 0.210491222195929 3825 4230158
SGTC_1115 galangin 695.678 nM -0.804933703833214 0.205992915479925 no 2728 0.21042896893606 3869 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1378 2093-0007 380 nM -0.805303137753632 0.205887697568136 no 2729 0.210322385776828 3913 3618014
SGTC_3312 9133330 71.43 µM -0.808686193942174 0.204925658184174 no 2730 0.209347835721414 3905 17617324
SGTC_1386 3228-0095 33.8 µM -0.809516947002908 0.204689826387395 no 2731 0.209108929433867 3858 870181
SGTC_1706 st031321 9.9705 µM -0.811372638382293 0.204163621486522 no 2732 0.208575853620287 3878 6103185
SGTC_2307 7538926 6.34 µM -0.811434624560546 0.204146058433885 no 2733 0.208558060978858 3879 96582
SGTC_2832 7992762 51.95 µM -0.811490893538579 0.204130116061746 no 2734 0.208541910189364 3808 2985177
SGTC_1970 st070122 35.8 µM -0.811542588236225 0.204115470348269 no 2735 0.208527072997793 3848 102928
SGTC_2418 pentamidine 31.67 µM -0.811921793038301 0.20400805632192 no 2736 0.208418254283707 3811 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_686 1319-0111 510 µM -0.814122599474834 0.203385318358967 no 2737 0.207787360204398 3864 4562600
SGTC_507 nimesulide 162 µM -0.814916959260714 0.203160825976539 no 2738 0.207559922423165 3884 4495 A COX2 inhibitor.
SGTC_961 1252-1571 372 µM -0.816651218543084 0.202671224815189 no 2739 0.207063888032838 3841 6813498
SGTC_1772 st048439 82.2 µM -0.817267996327154 0.20249727153922 no 2740 0.206887645906931 3910 2927068 YDL195W SEC31
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.817990089145925 0.202293729143773 no 2741 0.206681423233843 3852 6857784
SGTC_1832 st054113 55 µM -0.81964336052206 0.201828168664885 no 2742 0.20620972366744 3832 1251267
SGTC_2655 perillic acid 100 µM -0.82079421504067 0.201504467600493 no 2743 0.205881747146308 3897 5702197 An apoptosis inducer.
SGTC_510 ag-490 170 µM -0.821025763513344 0.201439377529718 no 2744 0.205815796670249 3979 5328779
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.824004542787543 0.200603143809674 no 2745 0.204968488373902 3875 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3160 9100216 49.47 µM -0.825622496477743 0.200149809961018 no 2746 0.204509134795689 3771 17191039
SGTC_2067 5224629 34.075 µM -0.826507833622099 0.199902008535662 no 2747 0.204258038088004 3860 2835000
SGTC_1507 4075-3230 155 µM -0.827427930388217 0.199644673671468 no 2748 0.203997277587937 3768 659771
SGTC_1294 1000-1494 117 µM -0.82758577981823 0.19960054600558 no 2749 0.203952562129288 3853 712797 YDL207W GLE1
SGTC_1735 st034310 56.75 µM -0.828398240743842 0.199373511007836 no 2750 0.203722501266417 3988 871153
SGTC_2347 9049783 174.81 µM -0.830044728267668 0.198913891759255 no 2751 0.203256747628317 3911 6467988 YPL169C MEX67
SGTC_215 1287-0124 461.5 µM -0.830614856061116 0.198754888773862 no 2752 0.203095619767649 3894 5560863
SGTC_1745 st081495 74 µM -0.831451849852899 0.198521598388365 no 2753 0.202859209221939 3796 13842402 YBL026W LSM2
SGTC_1432 4049-0298 68.4 µM -0.831888191902638 0.198400044850649 no 2754 0.202736028765457 3883 741646
SGTC_1226 3909-7979 35.4 µM -0.832561808683619 0.198212480952385 no 2755 0.20254595283802 3903 6615510
SGTC_678 1218-2179 85.9 µM -0.833028062848711 0.198082718437133 no 2756 0.202414451284473 3858 6820081 YOR116C RPO31
SGTC_2794 7785382 27.27 µM -0.834382507981515 0.197706055837626 no 2757 0.20203273548725 3809 2205081
SGTC_1958 st076513 41.9 µM -0.835457063945666 0.197407536786076 no 2758 0.201730206007527 3862 732122 YGL099W LSG1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.83546319451214 0.197405834454839 no 2759 0.201728480792306 3864 4620898
SGTC_293 4049-0273 38.5 µM -0.835567984103304 0.197376737930189 no 2760 0.201698993106005 3769 1380311
SGTC_150 3970-0969 77.2 µM -0.835934535651761 0.197274979371098 no 2761 0.201595866177722 3982 6615640
SGTC_1838 st055369 84.5 µM -0.837329615678344 0.196887980836932 no 2762 0.201203658344225 3874 676036
SGTC_1752 st044819 83.042 µM -0.837599523387032 0.196813160894081 no 2763 0.201127830308086 3900 441209 YML126C ERG13
SGTC_922 1866-0035 480 µM -0.838060470452513 0.196685423577165 no 2764 0.200998371192275 3842 3156169
SGTC_2484 5809818 12.04 µM -0.838195151503582 0.196648110343719 no 2765 0.200960554834618 3883 2870548
SGTC_2996 9066192 71.4286 µM -0.838654836113661 0.196520787538383 no 2766 0.20083151465147 3959 6472854
SGTC_1079 idarubicin 2.36 µM -0.841611939974325 0.19570292785004 no 2767 0.200002601863884 3858 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2786 7743617 45.45 µM -0.842026852759939 0.195588339047771 no 2768 0.199886461457427 3844 583674
SGTC_1861 st057647 17.4 µM -0.843271646865278 0.195244801775145 no 2769 0.199538268087224 3982 688668
SGTC_2822 7994718 71.43 µM -0.844023591341245 0.19503745849908 no 2770 0.199328111418634 3872 1018011
SGTC_316 k060-0003 58.6 µM -0.844071338439445 0.195024297101862 no 2771 0.199314771356481 3884 6152314
SGTC_2596 sinensetin 100 µM -0.848311784119514 0.193857580586869 no 2772 0.198132178277752 3936 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_797 k781-0471 270 µM -0.849827635020077 0.193441543626985 no 2773 0.197710461491952 3880 23738129
SGTC_259 usnic acid 108.925 µM -0.850482173817218 0.193262068917847 no 2774 0.197528533557846 3963 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_236 1509-0011 5.31 µM -0.85126674210769 0.193047074053276 no 2775 0.19731059756559 3965 3107280
SGTC_2403 6032726 181.2 µM -0.852315239025198 0.192759983052459 no 2776 0.197019575113585 3976 2881040
SGTC_212 3807-4682 38.772 µM -0.855713678505568 0.191831244101065 no 2777 0.196078086157842 3987 3125501 YBL034C STU1
SGTC_1150 3909-7983 10.9 µM -0.855769040776646 0.191816137194602 no 2778 0.196062771457654 3893 23965914
SGTC_4 0960-0234 25.671 µM -0.858020423559675 0.191202411330165 no 2779 0.19544059297802 3919 6821112
SGTC_1400 3771-8998 51.5 µM -0.861342086820818 0.190299128776907 no 2780 0.194524831133961 3829 670767
SGTC_795 0685-0265 78 µM -0.861915644828965 0.190143423044019 no 2781 0.194366969582691 3954 302754
SGTC_228 caffeine 993.056 µM -0.86209630733226 0.190094394200534 no 2782 0.194317261627572 3893 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_287 k060-0039 29.6 µM -0.862984678615627 0.189853417837643 no 2783 0.194072945455205 3956 5861974
SGTC_1350 1495-0454 146 µM -0.863294473214476 0.189769428271463 no 2784 0.193987791062337 3960 1069057
SGTC_170 4197-0004 226 µM -0.863815949011119 0.189628100642871 no 2785 0.193844502498641 3965 218692
SGTC_2657 nystatin 74.44 µM -0.865657558272367 0.189129515673608 no 2786 0.193338990552013 3960 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_129 0088-0017 176.636 µM -0.865723591986637 0.189111653153078 no 2787 0.193320879600438 3774 182446
SGTC_615 k087-0205 167 µM -0.867877713817878 0.188529520009259 no 2788 0.192730640240543 3914 9642773
SGTC_2918 7977171 22.06 µM -0.868695829338353 0.188308721062885 no 2789 0.192506761615886 3847 2236483
SGTC_1240 0356-0016 42.1 µM -0.868947502482568 0.188240829789949 no 2790 0.192437922844664 3923 4305613
SGTC_3276 9139060 49.47 µM -0.870684233750185 0.187772741488665 no 2791 0.191963294693585 4001 4870619
SGTC_2293 7624732 200 µM -0.870964223422413 0.187697345297066 no 2792 0.191886843941873 3836 894453
SGTC_3213 9129884 49.47 µM -0.871228535033585 0.187626188088188 no 2793 0.191814691165318 3933 17190742
SGTC_2149 5554786 194.827 µM -0.871549388626925 0.187539831209561 no 2794 0.191727125670293 3958 745063 YPR165W RHO1
SGTC_2682 pyrogallin 40.03 µM -0.871700388393336 0.187499198530821 no 2795 0.191685924165356 3939 822798 An ATP competetive kinase inhibitor.
SGTC_1384 3089-0840 101 µM -0.872188435157405 0.187367906750975 no 2796 0.191552793756562 3900 1069836
SGTC_2875 9039966 71.43 µM -0.872212170418277 0.187361523065109 no 2797 0.191546320647516 3958 6463691
SGTC_1469 k284-2957 126 µM -0.873218377762594 0.187091023568826 no 2798 0.191272029830632 3897 23884841
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.873301529376695 0.1870686806673 no 2799 0.191249373583831 3957 115019
SGTC_90 0870-0863 4.608 µM -0.873560345896478 0.1869991470374 no 2800 0.191178864605244 3925 1738164
SGTC_8 0354-0001 70 µM -0.874762469871543 0.186676394141042 no 2801 0.190851580826485 3923 4993152
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.875218545582012 0.186554034705475 no 2802 0.190727502119509 3933 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_994 3910-0338 138 µM -0.876584504006164 0.186187862288986 no 2803 0.190356179487931 4031 3479481
SGTC_1561 5-methoxyflavone 52.9 µM -0.879134223035288 0.185505551927113 no 2804 0.189664251891278 3875 94525
SGTC_3136 9095672 49.47 µM -0.880564697755953 0.18512343422604 no 2805 0.18927673650609 3679 17217380
SGTC_2411 st077133 39.94 µM -0.883004399985906 0.184472854089972 no 2806 0.188616947108033 4054 1403142 YNL221C POP1
SGTC_1221 2958-7315 257 µM -0.884761710511892 0.184005125312348 no 2807 0.188142582320331 3964 4562705
SGTC_2816 7982706 58.44 µM -0.885192673741192 0.183890532245479 no 2808 0.188026361509718 4012 2981853
SGTC_562 3772-2733 112 µM -0.885209464990124 0.183886068354322 no 2809 0.188021834195599 3966 2876874 YIL048W NEO1
SGTC_46 0329-0187a 2.197 µM -0.886210452342969 0.183620081520083 no 2810 0.187752066139836 4016 46494817
SGTC_2658 polymyxin b sulfate 77.05 µM -0.887901386094122 0.18317130394591 no 2811 0.187296899537776 3970 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2915 7971052 15.16 µM -0.888673310396689 0.182966661159825 no 2812 0.187089339477152 3826 5741558
SGTC_1934 st074720 32.6 µM -0.889517536855643 0.182743013949375 no 2813 0.186862501297269 3906 17250992
SGTC_1563 conessine 56.1 µM -0.890000894987062 0.182615042590314 no 2814 0.186732702753467 4027 441082 An anti-amoebic, histamine inhibitor.
SGTC_658 3253-0951 102 µM -0.890895256627595 0.18237840371619 no 2815 0.186492682625819 3961 1184878
SGTC_2544 sphondin 68.51 µM -0.893515219382235 0.181686291898835 no 2816 0.185790662764597 3941 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2625 euphol 100 µM -0.893978604595113 0.181564051344974 no 2817 0.185666669357567 3999 6708538 A triterpene alcohol.
SGTC_2439 5492030 7.2 µM -0.895069342397471 0.181276519044501 no 2818 0.185375010589488 3950 5722370
SGTC_3325 9138760 55.175 µM -0.896054586320437 0.181017041530243 no 2819 0.185111805090821 3907 43844959
SGTC_2438 5259590 200 µM -0.897425388234907 0.180656409387199 no 2820 0.184745985117698 3985 1201127
SGTC_67 0335-0847 266 µM -0.897757808103528 0.180569023904679 no 2821 0.184657341417896 4136 4552207 YOR254C SEC63
SGTC_3161 9100388 49.47 µM -0.898261818487909 0.180436581828235 no 2822 0.184522991526842 4027 25236368
SGTC_277 nystatin 15.5 µM -0.899156428188399 0.180201649566983 no 2823 0.184284672565411 3947 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_960 1222-0186 7.7 µM -0.899188993565771 0.180193101239803 no 2824 0.184276000947662 4018 3126296
SGTC_3084 9116877 49.47 µM -0.902375509408043 0.179357880277167 no 2825 0.183428713133501 3839 27241325
SGTC_159 3970-0959 50 µM -0.904236750115466 0.178871156542309 no 2826 0.182934938577066 4055 6615653
SGTC_2531 methyl deoxycholate 70.07 µM -0.905773899165066 0.178469811811184 no 2827 0.182527769369127 3923 16667744 Haematoxylin.
SGTC_2779 methotrexate 400 µM -0.906756496685819 0.178213556165898 no 2828 0.182267789876939 4000 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_978 1416-0512 87.4 µM -0.906869820480925 0.178184016909994 no 2829 0.182237821114745 4046 6814003
SGTC_1262 0737-0114 49.6 µM -0.907712669418462 0.177964414699865 no 2830 0.182015024234459 4050 765919
SGTC_1046 2001-0062 216 µM -0.907931876073308 0.177907328924583 no 2831 0.181957107536197 3886 739778
SGTC_2723 salbutamol 83.58 µM -0.908853101173297 0.177667549842403 no 2832 0.181713836202848 3999 9884233 β2-adrenoceptor agonist
SGTC_1969 st069479 40.1 µM -0.910711541070994 0.17718445079433 no 2833 0.181223690766394 3993 3895485
SGTC_1690 st023502 41.2 µM -0.912415807418866 0.176742158991559 no 2834 0.180774935676175 3975 24207482
SGTC_2698 st077697 67.5 µM -0.912556472017308 0.176705684873743 no 2835 0.180737928038636 3958 3154499
SGTC_1085 doxorubicin 7.67 µM -0.913306009851799 0.176511411095709 no 2836 0.180540811221482 4002 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1768 st044301 37.178 µM -0.914641012830059 0.176165724509568 no 2837 0.180190060257758 3987 3931349
SGTC_2305 7443522 69.23 µM -0.915063895253074 0.176056312472991 no 2838 0.180079043835362 3891 5415886
SGTC_2611 pyromycin 23.93 µM -0.916334989122506 0.175727702422633 no 2839 0.179745610868926 3989 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2267 7931562 200 µM -0.917496371267422 0.175427795584672 no 2840 0.179441296780208 3899 934880
SGTC_2055 5235184 200 µM -0.918593346602715 0.175144818848339 no 2841 0.179154156679149 4062 2836034
SGTC_195 4234-0266 16.654 µM -0.918717660094256 0.175112769103443 no 2842 0.179121635093829 3984 2303354
SGTC_2941 9056145 11.23 µM -0.920786410538081 0.174579962673785 no 2843 0.178580975648396 3856 2119517
SGTC_832 4083-0019 164 µM -0.924715590273438 0.173570840751875 no 2844 0.177556933842113 4062 1990758
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.925490022650344 0.173372383879274 no 2845 0.177355535609238 4010 616764
SGTC_2133 5320837 200 µM -0.926372991357881 0.173146289683429 no 2846 0.177126087558485 4034 2841355
SGTC_2388 9080168 200 µM -0.927165750572105 0.172943454722327 no 2847 0.176920241157149 3977 15943073
SGTC_1424 4048-1941 275 µM -0.927458280427573 0.172868646441806 no 2848 0.176844321593203 4070 X1424
SGTC_1335 1486-0900 202 µM -0.929654137238751 0.172307761344362 no 2849 0.176275093785659 3997 X1335
SGTC_2580 diallyl disulphide 81.36 µM -0.930492462205709 0.172093935581107 no 2850 0.176058082555202 3994 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1978 st071761 42 µM -0.931063928879666 0.171948272640027 no 2851 0.17591024802508 4028 5147680
SGTC_3221 9128209 49.47 µM -0.931825805253062 0.171754198038127 no 2852 0.175713278111075 4041 16460723
SGTC_888 0916-0002 6.97 µM -0.931873888233147 0.171741954440287 no 2853 0.17570085178033 4058 2802138 YIL048W NEO1
SGTC_131 0141-0277 33.849 µM -0.932711951533844 0.171528643938709 no 2854 0.175484356217074 3995 1547771
SGTC_738 1315-0003 72.4 µM -0.935520086030926 0.170815130016465 no 2855 0.17476016844064 4081 6251474
SGTC_2795 7780010 54.55 µM -0.93963043518043 0.169774168745054 no 2856 0.173703579569359 4019 953673
SGTC_980 1473-0395 201 µM -0.941443221528978 0.169316369321134 no 2857 0.173238886534317 3905 768876
SGTC_955 1216-0110 33 µM -0.942253805357019 0.169111921829872 no 2858 0.173031356325038 3995 3619719
SGTC_1209 2323-2347 50.3 µM -0.946037739267454 0.168159626904329 no 2859 0.172064668855957 4034 5412760
SGTC_1358 1509-0022 2.48 µM -0.946964473809548 0.167926924510775 no 2860 0.171828441089212 4052 3258434
SGTC_2965 9082772 38.63 µM -0.948551487030798 0.167528908268576 no 2861 0.17142438733954 4040 16459634
SGTC_1758 st042942 75.2445 µM -0.948567976070346 0.167524776079328 no 2862 0.171420192418259 3951 669317
SGTC_1029 k015-0030 64.7 µM -0.948824324374106 0.167460543081176 no 2863 0.171354984144755 4095 2208316
SGTC_3342 9147791 14.508 µM -0.952890693391991 0.166443758857789 no 2864 0.17032272796989 3931 1838168
SGTC_1650 st011916 45.8 µM -0.953197264520892 0.16636726351704 no 2865 0.170245066065188 3942 242528
SGTC_2125 5246583 200 µM -0.953402073115738 0.166316172519156 no 2866 0.170193195722415 4020 835267
SGTC_1667 st014849 34.6 µM -0.953813879405505 0.166213475108248 no 2867 0.170088931273657 4074 5348460
SGTC_356 1634-0012 32.5 µM -0.953968015083414 0.166175046856276 no 2868 0.17004991648631 4048 735457
SGTC_2304 7443016 91.4 µM -0.956619655129263 0.165514853416864 no 2869 0.169379632221483 3952 939854
SGTC_133 0724-0033 378.92 µM -0.958150451972567 0.165134495973812 no 2870 0.168993448939834 3886 280309
SGTC_2027 5150920 200 µM -0.959719145464097 0.164745309804173 no 2871 0.168598292449167 3983 786715
SGTC_979 1426-2828 121 µM -0.96009778364823 0.164651460377166 no 2872 0.168503001920056 4142 747872
SGTC_29 0299-0004 12.984 µM -0.962876929827005 0.163963680469647 no 2873 0.167804644172711 3934 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2466 5983409 37.09 µM -0.969000711609186 0.162454763036916 no 2874 0.166272417064296 4070 2879657
SGTC_1184 1269-1718 139 µM -0.972959686086623 0.16148408539363 no 2875 0.165286669347515 4134 5403821
SGTC_802 4112-3352 742 µM -0.975206608161491 0.160934861515544 no 2876 0.164728892448861 4121 704594
SGTC_1443 4112-3303 14 µM -0.976314427834181 0.160664522163827 no 2877 0.164454336167041 4098 704433
SGTC_1553 gossypol 38.6 µM -0.976903445153403 0.160520906104125 no 2878 0.164308478021081 3929 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1458 k015-0034 6.33 µM -0.978280875376137 0.160185384205283 no 2879 0.163967713006777 4092 3598957
SGTC_121 0557-0495 61.343 µM -0.979752959456797 0.159827313166649 no 2880 0.163604038658932 4174 3104427
SGTC_1947 st076332 61.6 µM -0.98055310606856 0.159632904615036 no 2881 0.16340658449866 3964 24208416
SGTC_1661 st013063 9.66 µM -0.9808656908648 0.159556999140744 no 2882 0.163329489239834 4119 721395
SGTC_3345 9148410 3.559 µM -0.981434553423882 0.159418921946156 no 2883 0.163189246813472 4042 4903596
SGTC_836 0330-0104 1.35 µM -0.981928155075372 0.159299175867324 no 2884 0.1630676219833 4080 46494820
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.982075758716732 0.159263379170074 no 2885 0.163031263479189 4061 676296 Flavone; oxidizing agent.
SGTC_2819 7996655 46.38 µM -0.984082819790923 0.158777151465797 no 2886 0.162537396703683 4029 6456960
SGTC_1179 1021-1431 9.29 µM -0.984515472910366 0.158672465173714 no 2887 0.162431063737752 4106 2840958
SGTC_3239 9133757 49.47 µM -0.984833536869527 0.158595534153701 no 2888 0.162352922180505 4087 17036923
SGTC_3293 9120939 62.045 µM -0.985706958452382 0.158384403056812 no 2889 0.162138466931457 4075 934087
SGTC_3201 9113999 49.47 µM -0.985743625034728 0.158375543724837 no 2890 0.162129468051963 4106 16649224
SGTC_2266 7929956 200 µM -0.989148535023069 0.157554270629542 no 2891 0.16129523703951 4039 2967153
SGTC_352 k048-0007 5.11 µM -0.990056772706854 0.157335674987557 no 2892 0.161073185198995 4063 6811911
SGTC_1302 1159-0335 255 µM -0.991277872401565 0.157042093742527 no 2893 0.160774957372013 4086 649284
SGTC_282 k297-0036 65.7 µM -0.99141141954304 0.157010007724013 no 2894 0.160742363187008 4086 5061378
SGTC_1015 4130-4525 82 µM -0.992864912292765 0.15666107064012 no 2895 0.160387895522617 4080 1363237
SGTC_1523 st012844 44.7 µM -0.993405029986956 0.156531535854859 no 2896 0.160256305658018 4187 4274103
SGTC_2627 acetyl isogambogic acid 100 µM -0.994260933318536 0.156326411617188 no 2897 0.160047924913664 4116 6857789 A caspase activator and apoptosis inducer.
SGTC_3303 9125618 40.5795 µM -0.994608106371545 0.156243259250033 no 2898 0.159963451671192 4107 22695467
SGTC_508 roscovitine 141 µM -0.994692168507195 0.15622312968066 no 2899 0.159943002277079 4156 160355 A CDKinase inhibitor.
SGTC_1051 3253-3903 78 µM -0.996669723151968 0.155750076143683 no 2900 0.159462425248409 4065 5509239
SGTC_2232 chlorophetanol 41.5365 µM -0.999170623542589 0.155153186353217 no 2901 0.15885602197538 4156 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1208 2323-2347 50.3 µM -0.999684242322392 0.155030788149185 no 2902 0.158731670108073 4111 5412760
SGTC_2372 9071633 200 µM -1.00449299101065 0.153887930348796 no 2903 0.157570523960806 4123 21321366
SGTC_1892 st058411 7.36 µM -1.00494747129995 0.15378020668211 no 2904 0.157461072120251 4112 3934738
SGTC_536 3852-0578 10.6 µM -1.00525264201418 0.153707901291841 no 2905 0.157387606338477 4158 2869208
SGTC_926 2268-1401 59.4 µM -1.00555954177841 0.153635208932812 no 2906 0.157313747036746 4056 2931578
SGTC_2425 5628681 7.85 µM -1.00670311522194 0.153364542289736 no 2907 0.15703873232851 4163 5714958
SGTC_1904 st060225 78 µM -1.0089803986293 0.152826484978093 no 2908 0.156492017411948 4035 66595
SGTC_972 1319-0219 195 µM -1.00986764719428 0.152617192657957 no 2909 0.156279352400275 4085 23903702
SGTC_506 n9-isopropylolomoucine 153 µM -1.01021812330135 0.152534571559484 no 2910 0.156195399100608 4115 6610355
SGTC_3218 9131285 49.47 µM -1.01105468105032 0.152337481753446 no 2911 0.155995129581842 4063 17156417
SGTC_196 k015-0023 18.111 µM -1.01135519571202 0.152266722935598 no 2912 0.155923228572916 4031 5211998
SGTC_2376 9072922 81.32 µM -1.0123849164264 0.152024431642359 no 2913 0.15567702373694 4132 17087968
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.01407026610891 0.151628424949703 no 2914 0.155274612419973 4125 2374 Ca(2+)-ATPase inhibitor.
SGTC_1831 st055328 12 µM -1.01581387641961 0.151219451017017 no 2915 0.154859013400301 4108 1103068
SGTC_2854 9024559 71.43 µM -1.02456274788176 0.149178439058472 no 2916 0.152784774654173 4165 3163529
SGTC_2465 5809242 33.21 µM -1.02470651444334 0.149145054325627 no 2917 0.152750844155113 4156 2731748
SGTC_1273 0849-0096 14.1 µM -1.02564090323047 0.148928196968176 no 2918 0.152530439871233 4140 5286025
SGTC_17 0960-0276 49.807 µM -1.02645858981808 0.148738597340235 no 2919 0.152337736601061 4098 6821114
SGTC_2734 clemastine 41.6 µM -1.02857746064856 0.148248038912734 no 2920 0.151839136970679 4155 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1145 3546-0597 10.2 µM -1.02925144674845 0.148092225629003 no 2921 0.151680766272064 4100 875334
SGTC_685 1278-0033 54.9 µM -1.02940987225557 0.148055616457368 no 2922 0.151643555988619 4187 3590572
SGTC_2760 etidronate 98.04 µM -1.03252771273707 0.147336374352844 no 2923 0.150912486105507 4076 3305 A chelator and antioxidant.
SGTC_1972 st070201 17.4 µM -1.03262624919491 0.147313681609574 no 2924 0.150889419625862 4122 2829099
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.03318992060012 0.147183914274314 no 2925 0.150757514439603 4004 17037758
SGTC_2296 7971656 126.45 µM -1.03353602899652 0.147104271855959 no 2926 0.150676559397994 4173 666570
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.03449226501592 0.146884384217166 no 2927 0.150453045497636 4162 6708561
SGTC_2373 9071805 200 µM -1.03476334516386 0.146822089135505 no 2928 0.150389722495533 4134 10149009
SGTC_1413 3910-0535 34.4 µM -1.03625189734243 0.146480331003356 no 2929 0.150042320467707 4139 2876951
SGTC_1444 4112-3581 28 µM -1.03816765779292 0.146041276181997 no 2930 0.149596003521247 4160 2877249
SGTC_2904 7225135 42.03 µM -1.03917008063627 0.145811893178258 no 2931 0.149362821314273 4234 4446116
SGTC_41 0478-0632 82.643 µM -1.03981509920489 0.145664422597563 no 2932 0.149212906361638 4067 3750424
SGTC_1472 k841-0093 193 µM -1.03987628567013 0.14565043874638 no 2933 0.149198690648048 4231 X1472
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.04114350607413 0.145361024973317 no 2934 0.148904475241853 4171 279621
SGTC_3166 9102297 49.47 µM -1.04129095397473 0.145327375268616 no 2935 0.148870266893986 4139 25237072
SGTC_2218 6965428 192.983 µM -1.042718181601 0.145001932521317 no 2936 0.148539417313313 4020 675684
SGTC_79 0052-0007 94.094 µM -1.04308053265347 0.144919385781471 no 2937 0.148455498029251 4144 2801472
SGTC_394 menadione 8.33 µM -1.04373049229103 0.144771398575606 no 2938 0.148305049022451 4117 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1627 st003713 25.6 µM -1.04413384348771 0.144679612040503 no 2939 0.148211734857296 4171 16195070 YER133W GLC7
SGTC_2158 5657123 3.6195 µM -1.0484705148937 0.143695236157375 no 2940 0.14721094002893 4101 2858827
SGTC_1347 1493-0251 600 nM -1.04867756734586 0.143648350882581 no 2941 0.147163271097149 4193 3986378
SGTC_2764 methyldopa 94.69 µM -1.04878930544355 0.143623053026011 no 2942 0.147137550341572 4148 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3251 9135047 49.47 µM -1.0494950815967 0.143463332565789 no 2943 0.146975158868366 4163 17682963
SGTC_1245 0418-0076 17.2 µM -1.04960916340499 0.143437526578889 no 2944 0.146948921164751 4191 6790114
SGTC_2587 piperic acid 92.2 µM -1.05011418656183 0.143323324969174 no 2945 0.14683280849822 4137 5370536
SGTC_925 2064-1272 59.6 µM -1.05067550974028 0.143196464223019 no 2946 0.146703823821142 4117 6815817
SGTC_2124 5246320 200 µM -1.05072097170932 0.143186193000892 no 2947 0.146693380588219 4158 579342
SGTC_222 nsc-310342 10.666 µM -1.05343668029535 0.142573535655003 no 2948 0.146070450210539 4149 432556
SGTC_75 0159-0059 199.013 µM -1.05413664992996 0.142415911949788 no 2949 0.145910179350972 4251 5377270
SGTC_3003 9075612 71.4286 µM -1.05589794976319 0.142019812668413 no 2950 0.145507420464227 4173 6501993
SGTC_2031 5180455 200 µM -1.05604338363974 0.141987139362273 no 2951 0.145474197345891 4103 29949
SGTC_1105 epirubicin 18.1 µM -1.0561530273563 0.141962510070535 no 2952 0.145449153555061 4185 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3025 9087895 49.47 µM -1.05801279648281 0.141545190330878 no 2953 0.145024804238504 4142 17173641
SGTC_1828 st055811 49 µM -1.06200260052993 0.140652711762843 no 2954 0.144117252309976 4173 5877589
SGTC_757 1066-0008 322 µM -1.06633077968449 0.139688869601777 no 2955 0.143137070169533 4193 6842497
SGTC_2491 paeonol 100 µM -1.06889634873735 0.13911966782318 no 2956 0.142558188706326 4076 11092 Increases levels of cortical cytochrome oxidase.
SGTC_365 0121-0052 13.6 µM -1.0700933474124 0.138854640371379 no 2957 0.142288646642536 4189 3101739
SGTC_857 0438-0306 1.35 µM -1.07098237151973 0.138658024205246 no 2958 0.142088678079408 4230 4686136
SGTC_2216 7189485 200 µM -1.07324033529746 0.138159506839132 no 2959 0.141581648763454 4174 731273
SGTC_281 1672-3440 14.9 µM -1.07326014774956 0.138155138025357 no 2960 0.141577205278091 4212 6833000
SGTC_1504 k297-0033 30 µM -1.07746890829253 0.137229205546894 no 2961 0.140635416875487 4043 4388117
SGTC_2934 9036370 36.88 µM -1.07756806952966 0.137207441184545 no 2962 0.140613279096555 4165 6462800
SGTC_1239 0337-0584 35.4 µM -1.07764274136502 0.137191053424561 no 2963 0.140596610145907 4244 914301 YML130C ERO1
SGTC_2811 7967822 32.47 µM -1.07817854011915 0.137073504244023 no 2964 0.140477043439782 4225 2232244
SGTC_1364 1653-0028 37.6 µM -1.07837029198404 0.1370314524234 no 2965 0.140434269639392 4161 5718652
SGTC_2970 9090938 41.86 µM -1.07851655250878 0.136999382931408 no 2966 0.140401649469447 4246 17217104
SGTC_2945 9067681 61.76 µM -1.07943362008069 0.136798421022084 no 2967 0.140197235129599 4246 16456930
SGTC_817 1391-0715 46 µM -1.08010048150719 0.136652414723825 no 2968 0.140048718743561 4169 1353946
SGTC_2115 tiliquinol 12.7705 µM -1.08023877787117 0.136622148704468 no 2969 0.140017932215308 4150 71208 A bioactive hydroxyquinoline.
SGTC_2982 9019404 25.97 µM -1.08301434586944 0.136015687526811 no 2970 0.139401027733669 4115 22333232
SGTC_106 0092-0003 11.579 µM -1.08323594830027 0.135967346997593 no 2971 0.139351853668721 4092 1072148
SGTC_2260 7964312 200 µM -1.08725775050112 0.135092071479867 no 2972 0.138461457395581 4234 231951
SGTC_2533 agelasine 13.65 µM -1.08971206057137 0.134559835905175 no 2973 0.137920000864249 4256 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_868 0527-0199 213 µM -1.0898883417401 0.13452166349025 no 2974 0.137881166345959 4142 2849450
SGTC_908 3448-7491 47.7 µM -1.09093849380213 0.13429441469355 no 2975 0.137649973771638 4186 1203031
SGTC_2143 5623677 140.463 µM -1.09292172491609 0.133865970661789 no 2976 0.137214084395886 4150 5375313
SGTC_418 lividomycin a 100 µM -1.09536123024454 0.133340245961137 no 2977 0.136679206070048 4216 72394 An antibiotic.
SGTC_1381 2324-0066 62.1 µM -1.10121194045801 0.132085184852202 no 2978 0.135402213055225 4241 10885928
SGTC_2595 hexamethylquercetagetin 100 µM -1.10323727265711 0.131652626199907 no 2979 0.134962069481811 4186 386331
SGTC_1628 st004252 77.7 µM -1.10352137985031 0.131592026514146 no 2980 0.1349004061099 4226 692968
SGTC_2478 5763493 32.33 µM -1.10434877557296 0.131415653794073 no 2981 0.134720936080021 4124 1365576 YLR208W SEC13
SGTC_2148 5546263 113.568 µM -1.10511334409767 0.13125281885121 no 2982 0.134555239585339 4182 792097
SGTC_574 1315-0397 40 µM -1.10541060285703 0.131189547427929 no 2983 0.134490855759132 4168 6794277
SGTC_1235 benzylparaben 21.5 µM -1.10735232082222 0.130776771682951 no 2984 0.134070815760449 4224 7180
SGTC_1336 1486-0901 104 µM -1.10985163838423 0.130246782541753 no 2985 0.133531481595865 4226 5006114
SGTC_2784 7567673 72.73 µM -1.11032870993569 0.130145786970725 no 2986 0.13342870292452 4173 3471247
SGTC_3292 9120825 59.784 µM -1.11326079715071 0.129526257173685 no 2987 0.132798219054121 4216 24824900
SGTC_3322 9139058 2.11 µM -1.11346920158248 0.129482300657917 no 2988 0.132753484276064 4281 4908926 YPR165W RHO1
SGTC_1093 fluphenazine 7.97 µM -1.11486585447217 0.129187986342966 no 2989 0.132453955436236 4216 6602611 An atypical antipsychotic.
SGTC_3104 9120930 49.47 µM -1.11512379091959 0.12913368260131 no 2990 0.132398688879392 4233 17014836
SGTC_2395 5646831 180.19 µM -1.1165739263166 0.128828678048281 no 2991 0.132088272561038 4235 6808628
SGTC_1876 myriocin 605 nM -1.11858713672633 0.128406071887503 no 2992 0.131658156822333 4217 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.11899541797329 0.128320484413123 no 2993 0.13157104690184 4243 4174840
SGTC_1699 st031318 29.054 µM -1.11983928903761 0.1281437103643 no 2994 0.131391126672167 4248 5340658
SGTC_2079 5212404 121 µM -1.12193633512103 0.127705153938756 no 2995 0.130944755077654 4188 758462
SGTC_1708 st033234 31.827 µM -1.12369176854872 0.127338842217951 no 2996 0.130571904823543 4304 674664
SGTC_1811 st050069 61.5 µM -1.1279773421879 0.126447630405121 no 2997 0.129664744096265 4189 3877702
SGTC_188 3229-0966 278.469 µM -1.12965639622649 0.126099648220343 no 2998 0.129310518644982 4249 5722370
SGTC_1334 1486-0610 236 µM -1.13082493297774 0.125857864538694 no 2999 0.129064391781615 4294 3742339
SGTC_2719 novobiocin 32.65 µM -1.13098569754492 0.125824625820836 no 3000 0.129030555656228 4255 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3041 9091929 49.47 µM -1.13128431295264 0.125762902139458 no 3001 0.128967722383641 4232 25236887
SGTC_2558 carylophyllene oxide 100 µM -1.13176120691958 0.125664372159278 no 3002 0.128867420571104 4349 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1671 st016596 74.5 µM -1.13677734827776 0.124631260486775 no 3003 0.127815687492489 4292 2829167
SGTC_730 1436-0052 41.2 µM -1.13960794193397 0.124050905991473 no 3004 0.127224837563498 4262 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3271 9137798 49.47 µM -1.14211370432971 0.123538731592193 no 3005 0.12670337986629 4177 6498326
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.14438268274598 0.123076234846045 no 3006 0.126232483383107 4265 5282362
SGTC_729 4092-0585 94.1 µM -1.14459022514518 0.123033991149235 no 3007 0.126189471669072 4239 2169061
SGTC_2896 9052656 71.43 µM -1.14490185863911 0.122970579582812 no 3008 0.126124906988802 4027 6469436
SGTC_1292 0kpi-0043 232 µM -1.15022438404604 0.121891081991679 no 3009 0.125025732785722 4261 3333905
SGTC_1333 1482-0047 286 µM -1.15140586117611 0.121652364150404 no 3010 0.124782651838942 4254 3811116
SGTC_623 k072-0108 16.9 µM -1.1536386094288 0.121202134189707 no 3011 0.124324181182992 4212 5382803
SGTC_1167 k781-0610 148 µM -1.15380018850022 0.121169597573601 no 3012 0.124291048444544 4278 4525169
SGTC_104 0074-0074 590.992 µM -1.15778095246189 0.120369944472134 no 3013 0.123476719170995 4012 3943124
SGTC_3091 9116372 49.47 µM -1.15831147305809 0.120263655225357 no 3014 0.123368475517519 4310 17169793
SGTC_1951 sophoraflavanone G 9.2 µM -1.15879558782416 0.120166721053392 no 3015 0.123269758205912 4212 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2180 6301957 200 µM -1.16195040651386 0.119536380836973 no 3016 0.12262780515608 4276 845462
SGTC_1214 0358-0031 63.7 µM -1.16436951614777 0.119054619615681 no 3017 0.122137147897368 4331 4301366
SGTC_410 α-linolenic acid 100 µM -1.1671716043832 0.118498304463557 no 3018 0.121570537860627 4299 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_112 phenothiazine 287.218 µM -1.16752084920592 0.118429095798527 no 3019 0.121500046790562 4211 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1622 st003707 19.4 µM -1.16805710748523 0.118322882934137 no 3020 0.121391865132674 4277 10140899
SGTC_661 1304-0007 33.6 µM -1.16851535209431 0.118232175058093 no 3021 0.121299475180029 4253 3117130
SGTC_898 1000-0849 28.3 µM -1.16866715596895 0.118202136870805 no 3022 0.121268879828184 4256 6751807
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.16990482073512 0.117957435336849 no 3023 0.121019636844454 4274 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3072 9116419 49.47 µM -1.17029748738758 0.117879875252277 no 3024 0.120940636346699 4304 17170162
SGTC_308 4092-1169 104 µM -1.17139959404867 0.117662378334145 no 3025 0.120719097687787 4198 2268590 YDL196W YDL196W
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.17616407703331 0.116725392741676 no 3026 0.119764658210986 4265 5024745
SGTC_909 3448-9333 149 µM -1.17824718292295 0.11631739459319 no 3027 0.119349038675319 4189 3344074
SGTC_373 0844-0104 25.9 µM -1.18040434754544 0.115895958772298 no 3028 0.118919716823109 4282 5375804
SGTC_214 4373-3496 70 µM -1.18128632255933 0.115723963804022 no 3029 0.118744499446769 4356 3779166
SGTC_327 1273-0057 3.96 µM -1.18148250804699 0.115685730106047 no 3030 0.118705549107746 4158 3108138
SGTC_1903 st060211 78.3 µM -1.186138722765 0.114780933970302 no 3031 0.117783760291597 4299 688960
SGTC_426 0988-0037 14.6 µM -1.19066484684795 0.113906253677985 no 3032 0.116892591670294 4324 5383008
SGTC_1724 st037281 8.293 µM -1.19157557765464 0.113730829094314 no 3033 0.116713852934557 4237 574124 YDL195W SEC31
SGTC_2925 9010536 32.5 µM -1.1967470771234 0.112738348105939 no 3034 0.115702575839433 4200 2994177
SGTC_1874 staurosporine 7.6 µM -1.20167896179433 0.111797628175243 no 3035 0.114743967623005 4296 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1078 idebenone 36.1 µM -1.20309274923541 0.111528997185792 no 3036 0.114470215471152 4334 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_406 estrone 100 µM -1.20473325013057 0.111217868120342 no 3037 0.114153147820581 4275 5870 A steroid.
SGTC_560 2332-1943 155 µM -1.20551456882514 0.111069905845925 no 3038 0.114002358627975 4265 21177716
SGTC_353 1988-1175 58.3 µM -1.20581272869612 0.111013478982147 no 3039 0.113944853226967 4129 2788357
SGTC_2001 4023502 57.655 µM -1.2060221551267 0.110973857231601 no 3040 0.113904473997112 4315 108941 YCR052W RSC6
SGTC_2769 toremifene 3.73 µM -1.20860344968373 0.110486329275027 no 3041 0.113407615232054 4329 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1339 1486-1321 22.7 µM -1.20912147990753 0.110388674410682 no 3042 0.113308089041597 4320 3469382
SGTC_1748 st037455 53.6035 µM -1.20927540780142 0.110359669100716 no 3043 0.113278527764455 4334 580690
SGTC_774 k060-0086 136 µM -1.20988939599432 0.11024402698036 no 3044 0.113160668365618 4293 5911235
SGTC_1311 1190-0148 100 µM -1.21101551040785 0.110032153946202 no 3045 0.112944730148527 4350 1961333
SGTC_2470 5664817 21.68 µM -1.21295433667516 0.10966805785527 no 3046 0.11257363968685 4329 2859561
SGTC_2659 sanguinarine 24.21 µM -1.21438333991344 0.10940025671258 no 3047 0.112300687148857 4235 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1555 citronellol 128 µM -1.21542192874292 0.109205915822106 no 3048 0.112102604282772 4262 8842 A terpine precursor.
SGTC_1498 4478-3555 97.6 µM -1.21831582420408 0.108665718529747 no 3049 0.111551989474455 4274 3437919
SGTC_1281 0884-0031 11.8 µM -1.21956328758897 0.108433450935235 no 3050 0.11131523534972 4319 1548255
SGTC_2752 diclazuril 33.15 µM -1.21989536261352 0.108371681495062 no 3051 0.111252272014475 4240 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_237 nikkomycin 200 µM -1.22052606446615 0.108254434050998 no 3052 0.111132757522802 4312 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_43 0570-0105 72.5 µM -1.22126745949159 0.108116725524033 no 3053 0.110992384881884 4291 1114046 YDL195W SEC31
SGTC_2157 5649910 96.377 µM -1.22172213349646 0.108032335670715 no 3054 0.110906361650561 4283 2858091
SGTC_1057 3448-5381 134 µM -1.22217828198375 0.107947719814275 no 3055 0.11082010745469 4286 5497911
SGTC_2497 7-hydroxyflavone 100 µM -1.22390207296644 0.107628386387076 no 3056 0.110494585764988 4310 5281894
SGTC_1157 4092-0394 27.6 µM -1.22532021764091 0.107366184906408 no 3057 0.110227296888195 4380 3659885
SGTC_1326 1431-2094 10.8 µM -1.22697725415162 0.107060398314261 no 3058 0.109915570072189 4286 616278
SGTC_3062 9077494 49.47 µM -1.22771514145447 0.106924432216148 no 3059 0.10977696020994 4267 16459633
SGTC_1508 1080-0625 72.9 µM -1.23023449698547 0.106461144413771 no 3060 0.109304652616303 4202 767111
SGTC_270 tamoxifen 5.46 µM -1.23085149493966 0.106347905063732 no 3061 0.109189205893322 4355 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2106 5357045 167.29 µM -1.23344680180906 0.105872533624042 no 3062 0.108704556420583 4322 668842
SGTC_2359 9039622 200 µM -1.2383171041383 0.104984609734417 no 3063 0.107799252074413 4274 6463596
SGTC_443 clozapine 122 µM -1.23874643617339 0.104906595849354 no 3064 0.10771970797383 4283 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_682 0kpi-0099 17 µM -1.2405315540996 0.10458267228469 no 3065 0.107389425299703 4331 1714895 YML126C ERG13
SGTC_1954 st077032 68.9 µM -1.24137470542345 0.104429928078632 no 3066 0.107233679436643 4269 698907
SGTC_1428 4049-0204 61.7 µM -1.24329629152402 0.104082420159174 no 3067 0.106879335142411 4354 X1428
SGTC_2087 5276107 200 µM -1.2448557703645 0.103801014193762 no 3068 0.106592385739219 4275 144405
SGTC_3159 9100096 49.47 µM -1.24729486339282 0.103361990278728 no 3069 0.106144700096562 4260 25236875
SGTC_276 colchicine 750 µM -1.2526045373902 0.102410941357099 no 3070 0.105174831379681 4383 2833 A microtubule depolymerizer.
SGTC_2030 5175110 200 µM -1.25303556042028 0.102334018285712 no 3071 0.105096382754325 4333 2831986
SGTC_321 4534-3890 65.3 µM -1.25488603485099 0.10200424846011 no 3072 0.104760067141926 4321 699746
SGTC_993 3909-8757 62.7 µM -1.25540376060102 0.101912124047819 no 3073 0.104666112439406 4267 4288324 YLR208W SEC13
SGTC_1852 st056254 31.4 µM -1.25879763338249 0.101309715631567 no 3074 0.104051717696185 4281 442583
SGTC_527 4476-4215 268 µM -1.2625000298373 0.100655508038273 no 3075 0.103384457783316 4339 4418754
SGTC_1625 st003711 30.1 µM -1.26629658690882 0.0999878678944342 no 3076 0.102703459226821 4387 24207034 YER133W GLC7
SGTC_1084 voriconazole 435 nM -1.26878883527453 0.0995513575320042 no 3077 0.102258194097162 4356 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_647 0140-0236 81 µM -1.27216963010288 0.0989614489638764 no 3078 0.101656427813947 4353 990837
SGTC_2448 5185112 27.17 µM -1.28554512439011 0.0966526531237627 no 3079 0.0993009293754322 4357 5718189
SGTC_813 k007-0158 173 µM -1.28869989725889 0.0961139085300452 no 3080 0.0987512191141856 4353 6523916
SGTC_875 0709-0210 25.7 µM -1.29074478433643 0.0957658818721689 no 3081 0.0983960949195471 4343 6251364
SGTC_83 0170-0301 39.027 µM -1.29331400443344 0.0953299323458079 no 3082 0.0979512394950771 4365 3089716
SGTC_1875 nocodazole 6 µM -1.29392915082623 0.0952257704107389 no 3083 0.0978449471403715 4392 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_213 1246-0773 967 nM -1.29968108202 0.0942558562203052 no 3084 0.0968551484407477 4388 6251622
SGTC_2160 5660466 132.927 µM -1.30141345578782 0.093965168943758 no 3085 0.0965584851421208 4295 2859134
SGTC_1798 st045719 60.953 µM -1.30153166684137 0.0939453576117292 no 3086 0.0965382662449715 4315 3980186
SGTC_2276 7947513 42.08 µM -1.30955110004253 0.0926085453354945 no 3087 0.0951738700964891 4306 2105100
SGTC_3023 9089636 49.47 µM -1.31439883078153 0.0918072984941353 no 3088 0.0943560118705185 4442 17249241
SGTC_134 0269-0018 6.916 µM -1.3216966874237 0.090610789009446 no 3089 0.0931345860892231 4347 4378915
SGTC_693 4161-2696 114 µM -1.32179888941543 0.0905941152103566 no 3090 0.0931175641334792 4419 805759
SGTC_2624 nerol 100 µM -1.32300061358294 0.0903982300803138 no 3091 0.0929175868912373 4294 637566 A natural product oil.
SGTC_567 1080-0542 68.4 µM -1.32317872720659 0.090369223735677 no 3092 0.0928879742893073 4266 5950415
SGTC_759 3486-0358 89.3 µM -1.32338849402959 0.0903350714352193 no 3093 0.0928531080760693 4370 875103
SGTC_1763 st044482 94.5 µM -1.32744395250951 0.089676681798643 no 3094 0.0921809342825449 4365 88505
SGTC_1058 3448-5425 97.3 µM -1.33028539600651 0.0892175133219766 no 3095 0.0917121285160083 4338 7279705
SGTC_1147 3809-1045 12.3 µM -1.331175174454 0.0890740881672019 no 3096 0.0915656890059538 4381 325925
SGTC_33 0986-0033 35.816 µM -1.33398351185455 0.0886225322670601 no 3097 0.0911046301137552 4348 2848082
SGTC_2944 9067346 25.62 µM -1.33461706609175 0.0885208984586806 no 3098 0.0910008547643871 4334 6473075
SGTC_1640 st009078 66.4 µM -1.34598735249058 0.0867116293106068 no 3099 0.0891532977250195 4371 690618
SGTC_3298 9116858 71.43 µM -1.34646694052447 0.0866359279907987 no 3100 0.0890759875805341 4461 2506942
SGTC_2618 avocadyne 43.43 µM -1.34704848933482 0.0865441987925701 no 3101 0.088982308189945 4327 3015189
SGTC_569 4130-2812 160 µM -1.34811866318284 0.0863755872683482 no 3102 0.088810109816317 4257 743552
SGTC_1980 st071811 45.7 µM -1.35191256701264 0.0857798166056889 no 3103 0.0882016434232237 4467 4974850
SGTC_2010 4012422 159 µM -1.35402190127651 0.0854499133847745 no 3104 0.0878646952552269 4358 952393
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.35459239738555 0.0853608503651223 no 3105 0.0877737285193605 4435 165521
SGTC_1940 st075990 51.1 µM -1.35679723673559 0.085017295426705 no 3106 0.0874228228826233 4460 1084979
SGTC_1366 1683-0113 21.9 µM -1.36075954419424 0.0844025007366049 no 3107 0.0867948452874674 4393 708623
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.36093957964346 0.0843746457345269 no 3108 0.0867663921204102 4421 7104
SGTC_132 0417-1715 25.805 µM -1.36165091197243 0.0842646561906785 no 3109 0.0866540398908847 4394 6769098
SGTC_2797 7859098 81.82 µM -1.36528023005881 0.0837051486245263 no 3110 0.0860824951246944 4378 972681
SGTC_3011 9081274 71.4286 µM -1.36567069044966 0.0836451206469288 no 3111 0.0860211738777853 4405 6625322
SGTC_53 0973-0023 39.979 µM -1.36716330043617 0.0834159502643311 no 3112 0.0857870628735563 4304 674768
SGTC_887 0885-0007 9.62 µM -1.37081056003878 0.0828579480468777 no 3113 0.0852170090894254 4447 5719458
SGTC_805 3852-0218 479 µM -1.37426774175451 0.0823316232470504 no 3114 0.0846792885134625 4395 6615355
SGTC_3170 9103054 49.47 µM -1.37457624604821 0.0822847788782745 no 3115 0.0846314285498169 4389 16432970
SGTC_2120 5538279 151.968 µM -1.3771499818169 0.0818947558119272 no 3116 0.0842329411861244 4384 2058197
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.37722647354163 0.0818831856362137 no 3117 0.0842211196812328 4425 140250 A respiratory chain inhibitor.
SGTC_3070 9117005 49.47 µM -1.37894604717973 0.0816234071115508 no 3118 0.0839556946689093 4522 8779016
SGTC_2249 haloperidol 116.36 µM -1.38075730251061 0.0813504505756025 no 3119 0.0836767979012633 4374 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3331 9141060 1.957 µM -1.38168109128954 0.0812115008365634 no 3120 0.0835348213779133 4376 4906567 YPR165W RHO1
SGTC_509 pifithrin 175 µM -1.38223802480186 0.0811278174219603 no 3121 0.0834493141222542 4501 4817 A p53 inhibitor.
SGTC_2170 morpholine 200 µM -1.38286493433913 0.0810336974542395 no 3122 0.0833531420086348 4459 121171 Reacts with secondary amines.
SGTC_1009 4106-0057 9.87 µM -1.38291798644172 0.08102573635324 no 3123 0.0833450072866102 4426 2928005
SGTC_586 0957-0265 8.15 µM -1.38985352848923 0.0799900506239025 no 3124 0.0822866798283313 4310 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_493 zm226600 134 µM -1.39058618796371 0.079881229674915 no 3125 0.0821754735444046 4439 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3026 9090633 49.47 µM -1.3920419264165 0.0796653430333627 no 3126 0.0819548511262726 4425 25236842
SGTC_1228 0124-0032 52.5 µM -1.39373157948859 0.079415320578871 no 3127 0.0816993381159413 4461 X1228
SGTC_2281 7943571 200 µM -1.39394673988522 0.0793835253986154 no 3128 0.0816668442462104 4519 1244024
SGTC_1560 lithocholic acid 53.1 µM -1.39614941860931 0.0790585800776518 no 3129 0.0813347523963386 4369 9903 A bile acid which acts as a detergent.
SGTC_414 piperonyl butoxide 100 µM -1.39790691640189 0.078800032413242 no 3130 0.0810705107248893 4439 5794 A potent inhibitor of cytochrome P450.
SGTC_2735 sertaconazole 140 nM -1.39883139941237 0.0786642879617141 no 3131 0.0809317740066548 4579 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_721 1187-1332 279 µM -1.40137384497229 0.0782918873743946 no 3132 0.0805511546679153 4418 25730
SGTC_2869 9037858 32.47 µM -1.40433097134164 0.077860430651639 no 3133 0.0801101578611362 4403 27187042
SGTC_1060 3448-7350 82 µM -1.40702662737136 0.0774686978990358 no 3134 0.0797097465897823 4371 570178
SGTC_1468 k284-1086 134 µM -1.41113021659544 0.0768752403347645 no 3135 0.0791031108881364 4443 15996457
SGTC_2960 9079389 5.97 µM -1.41719590743229 0.0760043639442288 no 3136 0.0782128290033981 4422 16457355
SGTC_2361 9034121 116 µM -1.41721863616888 0.076001114870281 no 3137 0.0782095073811436 4460 6496917
SGTC_2279 7948423 32.93 µM -1.42258418864126 0.0752370641731473 no 3138 0.0774283651072642 4406 1247112
SGTC_690 glyoxal 20.3 µM -1.42384195895931 0.0750588087706578 no 3139 0.0772461132336674 4251 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1330 1469-0054 61.8 µM -1.42473990799653 0.0749317456180122 no 3140 0.0771161992606972 4428 7102664
SGTC_3165 9101544 49.47 µM -1.42642172722722 0.0746942034279226 no 3141 0.0768733228741412 4448 5002184
SGTC_2336 9001819 198.65 µM -1.42892412203733 0.0743418263429077 no 3142 0.0765130217188543 4478 2989602
SGTC_71 0417-1750 47.813 µM -1.43317528027079 0.0737461073780915 no 3143 0.0759038760804717 4423 6811472
SGTC_1807 st050092 58.9 µM -1.43567258462077 0.0733978629763197 no 3144 0.0755477649302907 4476 5008496
SGTC_3122 9126309 49.47 µM -1.43749101271886 0.0731450789745181 no 3145 0.075289262342229 4551 17591206
SGTC_928 2764-0428 58.7 µM -1.43994924605331 0.0728044137826017 no 3146 0.0749408794482292 4480 662578
SGTC_1450 4112-4260 37.6 µM -1.44070132921784 0.0727004321615835 no 3147 0.0748345396156179 4452 1633175
SGTC_618 k072-0232 33.2 µM -1.44080542339245 0.0726860492583647 no 3148 0.0748198304275649 4494 5872756 YGL099W LSG1
SGTC_1054 3429-0080 167 µM -1.44133553541075 0.072612836408569 no 3149 0.0747449563485847 4474 1162877
SGTC_2217 6934799 96.0675 µM -1.44345659053119 0.072320466157005 no 3150 0.074445946231184 4436 675606
SGTC_2516 gossypol 71.55 µM -1.4530410649772 0.0710105607018034 no 3151 0.0731061763378529 4480 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3157 9099274 49.47 µM -1.45429441537232 0.0708406218178234 no 3152 0.0729323490598599 4493 17217662
SGTC_130 0136-0219 337.655 µM -1.45895001402057 0.0702121148230135 no 3153 0.0722894330287871 4339 234244
SGTC_1256 0570-0116 285 µM -1.46069298283263 0.069977920076937 no 3154 0.0720498578279717 4472 410638
SGTC_2678 equilin 100 µM -1.47151874197463 0.0685367502230248 no 3155 0.0705754413845029 4480 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1939 st074455 53.6 µM -1.47780473869627 0.0677105016188737 no 3156 0.0697300248278675 4433 1644229
SGTC_2012 4023501 200 µM -1.4787807435388 0.0675829058996464 no 3157 0.0695994620264881 4462 3477460
SGTC_430 0958-0115 16.4 µM -1.47985074792673 0.0674432349403933 no 3158 0.0694565410287796 4417 6833180
SGTC_2862 9027634 71.43 µM -1.48288776100219 0.0670480194059899 no 3159 0.0690521168550157 4443 5012562
SGTC_210 3551-0445 56.827 µM -1.48359368024798 0.0669564130961304 no 3160 0.0689583734962727 4484 2865180 YOR207C RET1
SGTC_2836 9010338 19.48 µM -1.48555118082999 0.0667028969816929 no 3161 0.0686989380957272 4444 2994051
SGTC_1017 4239-0030 168 µM -1.4864953851431 0.0665808788448414 no 3162 0.0685740683088962 4494 1149593
SGTC_3103 9120822 49.47 µM -1.49057977567192 0.0660550482345495 no 3163 0.0680359286871223 4498 17141819
SGTC_2134 5324836 1.464 µM -1.49632384000214 0.0653209999435922 no 3164 0.0672846427528508 4470 699272
SGTC_880 0833-0487 87.2 µM -1.49797349572128 0.065111360260692 no 3165 0.0670700683744359 4475 76075
SGTC_2327 6189656 200 µM -1.49931284371212 0.0649415391082947 no 3166 0.0668962459749443 4549 5349088
SGTC_1070 indatraline 8.81 µM -1.50090675988051 0.0647398885583812 no 3167 0.0666898397575019 4549 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_35 0133-0054 64.071 µM -1.50587981804702 0.0641138581344297 no 3168 0.0660490141672277 4461 99677
SGTC_2916 7875993 68.79 µM -1.50762119633135 0.0638957617048257 no 3169 0.0658257523216784 4393 1299250
SGTC_1837 st055472 66.5 µM -1.51022840813837 0.0635703043679161 no 3170 0.0654925761296723 4546 676091
SGTC_848 0368-0089 85.6 µM -1.5117435775574 0.0633817598246018 no 3171 0.0652995540096859 4492 762535
SGTC_1685 st024049 53.0905 µM -1.51656862355084 0.0627842404851295 no 3172 0.0646878161124023 4515 1941139
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.51665733376651 0.0627732961117074 no 3173 0.0646766109000646 4525 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2639 lactacystin 53 µM -1.51919607816547 0.0624607153014837 no 3174 0.0643565741025723 4522 3870 A proteasome inhibitor.
SGTC_2366 9070441 60.58 µM -1.5215332291077 0.0621740296248215 no 3175 0.0640630395536845 4486 6837235
SGTC_2932 9016711 44.54 µM -1.52320839882518 0.0619691779061017 no 3176 0.063853287751737 4492 7117328
SGTC_2229 7354935 190 µM -1.5252090215108 0.0617252180501451 no 3177 0.0636034855665773 4484 318112
SGTC_123 0083-0120 66.675 µM -1.5265799370319 0.0615584793170548 no 3178 0.0634327495417832 4490 16001701
SGTC_1011 4112-3381 17.4 µM -1.53042122234599 0.061093153134496 no 3179 0.0629562496080106 4551 2877139
SGTC_1792 st045773 43.6 µM -1.5328778238136 0.0607970092572126 no 3180 0.0626529804167849 4488 2919270
SGTC_952 1185-0122 232 µM -1.53700805134834 0.0603016410585092 no 3181 0.0621456688741287 4462 678600
SGTC_2546 rhodinyl acetate 100 µM -1.54272427837276 0.0596212708039187 no 3182 0.0614488443039286 4476 6708682
SGTC_877 0771-0151 33.1 µM -1.54575206950567 0.0592633349422255 no 3183 0.0610822283473187 4514 6166523
SGTC_3265 9137266 49.47 µM -1.54636069328973 0.0591915891813804 no 3184 0.0610087407507596 4497 17224265
SGTC_742 0kpi-0133 140 µM -1.54714041519606 0.0590997735930969 no 3185 0.0609146951114223 4554 2728852
SGTC_2238 6671620 73.2395 µM -1.55247739364942 0.0584743175037647 no 3186 0.0602740188675405 4433 729941
SGTC_1848 st056003 16.4 µM -1.55257880000857 0.0584624839117023 no 3187 0.060261896824619 4534 146492
SGTC_108 0509-0257 621.132 µM -1.55433316631589 0.0582580560876717 no 3188 0.0600524830883597 4486 536624
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.55930250517318 0.0576820502971537 no 3189 0.0594623995434861 4534 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3017 9080681 49.47 µM -1.56280621233934 0.0572786276075678 no 3190 0.0590490912765728 4549 16451914
SGTC_442 cape 100 µM -1.56895768462764 0.0565757115814585 no 3191 0.058328899634275 4560 5281787
SGTC_2319 6033012 152.6 µM -1.57353121144078 0.0560575230218222 no 3192 0.0577979335716591 4482 847246
SGTC_523 1934-0222 13.7 µM -1.57950919042735 0.0553858598570361 no 3193 0.0571096550841953 4505 1361595
SGTC_1959 st077091 55.8 µM -1.58029204159206 0.0552983742115021 no 3194 0.057020000787953 4535 821356 YKL052C ASK1
SGTC_1780 st038448 24.544 µM -1.58346453258954 0.0549449569090235 no 3195 0.0566578122131189 4558 728868 YDL195W SEC31
SGTC_720 r052-1644 49.9 µM -1.58520628546572 0.0547516850216606 no 3196 0.0564597364501511 4542 1422863 YOR257W CDC31
SGTC_2211 7117706 200 µM -1.58671572924553 0.0545846261334451 no 3197 0.0562885211283129 4505 822771
SGTC_1981 st071826 47 µM -1.58689152131447 0.0545651964401052 no 3198 0.0562686077762179 4579 11838600
SGTC_3254 9136651 49.47 µM -1.58816255326127 0.0544248763317768 no 3199 0.0561247931822474 4509 16454030
SGTC_474 dl-dihydrosphingosine 5 µM -1.58992820656346 0.0542304245675225 no 3200 0.0559254944036068 4520 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3250 9135583 49.47 µM -1.59191506110099 0.0540122696677031 no 3201 0.0557018954796488 4556 7699353
SGTC_24 0417-1663 219 µM -1.59704185626636 0.053452560364374 no 3202 0.0551281887182281 4555 4329390
SGTC_3013 9080133 71.4286 µM -1.59727554648837 0.0534271575597416 no 3203 0.0551021496010985 4585 17050193
SGTC_3344 9148862 3.898 µM -1.61406102412201 0.0516274145943341 no 3204 0.0532570952080446 4575 4905352
SGTC_1133 3473-0247 50 µM -1.61585422429205 0.0514380313492941 no 3205 0.0530629173126675 4518 711311
SGTC_168 3970-0862 530.542 µM -1.61870852042475 0.0511377238650452 no 3206 0.0527549963763445 4478 3135186
SGTC_1764 st044502 93.5 µM -1.61966027745565 0.0510378979200312 no 3207 0.0526526367611763 4580 8407
SGTC_2676 harmalol 100 µM -1.62360443966241 0.050625862819795 no 3208 0.0522301286636643 4514 5459187 A monoamine oxidase inhibitor
SGTC_1927 st060202 13.8 µM -1.63383308039416 0.0495696454805174 no 3209 0.0511469521156455 4498 688887
SGTC_599 1935-0052 86.5 µM -1.63444083201428 0.0495074462769937 no 3210 0.0510831602314269 4555 9557311
SGTC_149 3970-0822 46.1 µM -1.63450399725568 0.0495009853235817 no 3211 0.0510765338053747 4536 3114250 YBL034C STU1
SGTC_1442 4112-3290 3 µM -1.63465435253771 0.0494856087109687 no 3212 0.0510607633548465 4561 704353
SGTC_2746 daunorubicin 9.88 µM -1.63522578456765 0.0494272039771845 no 3213 0.0510008623956017 4586 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_230 MPP+ 141.667 µM -1.6384757568336 0.0490960775973502 no 3214 0.0506612436252664 4540 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_155 k072-0202 43.6 µM -1.64102060446072 0.0488380323953173 no 3215 0.0503965690826169 4555 5857737
SGTC_1558 st069300 45.6 µM -1.64482928938458 0.0484538613942308 no 3216 0.0500025101207881 4525 24208000
SGTC_1108 betulinic acid 729.144 nM -1.64617886205644 0.0483183152155461 no 3217 0.049863469928186 4550 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_325 2810-4341 181 µM -1.64857154810892 0.0480787482195559 no 3218 0.0496177207960227 4567 774970
SGTC_292 k038-0015 474 µM -1.65262942035999 0.0476746288586527 no 3219 0.0492031533367813 4553 46368540
SGTC_1849 st056239 19.2 µM -1.65644832235062 0.0472967974500709 no 3220 0.0488155310772575 4569 5393181
SGTC_2459 5811157 9.22 µM -1.6671443125827 0.0462513282169569 no 3221 0.0477428563332478 4530 2870684 YBR192W RIM2
SGTC_2598 perillyl alcohol 100 µM -1.66883742232333 0.0460875510839957 no 3222 0.047574802038038 4574 10819 An apoptosis inducer.
SGTC_546 peri-Naphthalide 147 µM -1.6788770564432 0.0451259500934746 no 3223 0.0465880034485484 4535 223824 A penicillin ester.
SGTC_2924 9010168 62.78 µM -1.68003996111298 0.0450156175821542 no 3224 0.0464747704864553 4570 2993929
SGTC_367 0335-0881 7.1 µM -1.68773012174578 0.0442914555972671 no 3225 0.0457315234132758 4510 23828853
SGTC_1636 st007707 68.9 µM -1.69525633849455 0.0435918518750964 no 3226 0.0450134017828869 4598 403051
SGTC_375 3970-0961 9.27 µM -1.70261149278758 0.0429167927841409 no 3227 0.0443203989377029 4572 2898222
SGTC_1606 st000094 49.2 µM -1.70373424971465 0.0428144928450394 no 3228 0.0442153732322914 4604 1242210
SGTC_1989 st071868 50.2 µM -1.70444688527966 0.0427496634036085 no 3229 0.0441488155258975 4590 16414057
SGTC_1727 st034309 9.9045 µM -1.70939594121735 0.0423016270854139 no 3230 0.0436888161273837 4602 870305
SGTC_2687 chenodiol 100 µM -1.7230505029497 0.0410851579830709 no 3231 0.0424396963009114 4613 5702181 A cholesterol synthesis inhibitor.
SGTC_1604 st002052 72.4 µM -1.72330896193062 0.0410624086592745 no 3232 0.0424163339853681 4629 6254834 YHR062C RPP1
SGTC_450 aminopyrene 156 nM -1.73557724482991 0.0399942627075486 no 3233 0.0413193061724278 4574 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1653 st012112 65 µM -1.73613085653074 0.0399465996711404 no 3234 0.0412703497585359 4578 720429
SGTC_2823 7987624 58.44 µM -1.74225168306371 0.0394226995837155 no 3235 0.0407322069803879 4536 2239440
SGTC_2081 5214970 32.255 µM -1.74269557296147 0.0393849241161043 no 3236 0.040693402688157 4552 2063512
SGTC_1824 st053723 68.6 µM -1.74311710181579 0.0393490788625778 no 3237 0.0406565809470088 4615 675225
SGTC_248 streptozotocin 5.23457 mM -1.74673466905469 0.0390425445609089 no 3238 0.0403416868273065 4643 5300 DNA alkylating agent.
SGTC_999 SEC7.066 22.7 µM -1.75433520891145 0.0384048457759863 no 3239 0.039686543057806 4587 740511 YDR170C SEC7
SGTC_476 mead acid 10 µM -1.76168252808828 0.0377964889989517 no 3240 0.039061475731448 4674 5312531 An omega 9 fatty acid.
SGTC_1307 1187-1599 12.2 µM -1.76615882398003 0.0374297237251479 no 3241 0.038684603460026 4633 1538471
SGTC_783 0848-0141 92.7 µM -1.7709282460013 0.0370421449903846 no 3242 0.0382863172876805 4570 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3187 9109394 49.47 µM -1.77478251914105 0.0367313362667985 no 3243 0.0379669019011889 4616 17098090
SGTC_1608 st001473 40.5 µM -1.77822507278732 0.0364555350169344 no 3244 0.0376834482911175 4592 7292267
SGTC_2943 9068529 45.32 µM -1.78412919702015 0.0359864711624478 no 3245 0.0372013369731092 4580 3270634
SGTC_903 1134-0042 114 µM -1.78579571220752 0.0358549701146036 no 3246 0.0370661706222283 4638 701009
SGTC_2182 6325192 200 µM -1.79244084779022 0.0353345263617238 no 3247 0.0365311882586586 4643 736248
SGTC_481 bay k-8644 50 µM -1.80207602201176 0.0345909241396705 no 3248 0.0357667228210082 4595 2303 A calcium channel antagonist.
SGTC_663 1486-0733 13.9 µM -1.80798980578006 0.0341409230788422 no 3249 0.0353040436011466 4631 722445 YPR165W RHO1
SGTC_351 caspofungin 25 nM -1.80950319104589 0.0340265408402199 no 3250 0.0351864324264106 4622 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3057 9095946 49.47 µM -1.80955480156891 0.0340226456605539 no 3251 0.0351824272426631 4660 24540043
SGTC_1006 4099-6547 255 µM -1.8218906025825 0.0331020941454335 no 3252 0.0342357932477284 4644 3146833
SGTC_1142 3253-1408 9.78 µM -1.83072710040565 0.0324553705307818 no 3253 0.0335706429959132 4626 256655
SGTC_462 ag-879 158 µM -1.83797915402407 0.0319324289298924 no 3254 0.03303273855957 4634 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1810 st050138 53 µM -1.83819726337098 0.031916809615386 no 3255 0.033016671456912 4650 3444541
SGTC_445 e6 berbamine 66 µM -1.85585555095514 0.0306730362822652 no 3256 0.0317370750164587 4639 6610268 A calcium/calmodulin antagonist.
SGTC_1575 cyproterone acetate 48 µM -1.85643681625836 0.0306327866404182 no 3257 0.0316956605828308 4623 9880 An androgen receptor antagonist and liver toxin.
SGTC_2483 5729050 27.16 µM -1.85907538627974 0.030450628729935 no 3258 0.0315082267853817 4618 2865180
SGTC_3319 9138450 16.7555 µM -1.86472212032298 0.0300638116440921 no 3259 0.0311101822600541 4604 2029690
SGTC_3237 9133362 49.47 µM -1.87049426111756 0.0296726237022049 no 3260 0.0307076065994236 4648 43845137
SGTC_760 0568-0725 82.9 µM -1.87117476826698 0.0296267841621935 no 3261 0.0306604304265787 4648 3916171
SGTC_1229 0139-0193 12.2 µM -1.87568493788885 0.0293244586358174 no 3262 0.0303492776829365 4683 3090752
SGTC_761 k216-0224 480 µM -1.87723147811816 0.0292213826977471 no 3263 0.0302431874888657 4653 1340404
SGTC_535 2293-4129 48.2 µM -1.88005597617622 0.029033908402224 no 3264 0.0300502247456362 4638 396118 YIL048W NEO1
SGTC_477 mead ethanolamide 10 µM -1.88418222383675 0.0287618287190046 no 3265 0.0297701655949591 4672 16061185
SGTC_81 0411-0046 9.971 µM -1.90143089081263 0.0276473245868515 no 3266 0.028622798293622 4678 12925265
SGTC_2460 5552655 174.22 µM -1.91922166232561 0.0265357380106524 no 3267 0.027478143578735 4637 5401989
SGTC_440 fluspirilene 35.1 µM -1.91929795191224 0.0265310529737978 no 3268 0.0274733185397546 4649 3396 An atypical antipsychotic.
SGTC_3227 9130768 49.47 µM -1.92425250006156 0.0262282646355508 no 3269 0.0271614706726061 4721 17720899
SGTC_386 1509-0011 3.07 µM -1.93195089244139 0.0257635266407935 no 3270 0.0266827836883939 4672 3107280
SGTC_2480 5767542 37.17 µM -1.93417285080282 0.0256306797839073 no 3271 0.0265459396104056 4609 2867358
SGTC_625 k213-0058 121 µM -1.94152361932266 0.0251952709136202 no 3272 0.0260973986853044 4710 3655420
SGTC_1878 temozolomide 1 mM -1.94158530552782 0.0251916434390793 no 3273 0.0260936616039186 4640 5394 DNA alkylating agent.
SGTC_2568 diosmetin 100 µM -1.94743560967493 0.0248495982318479 no 3274 0.0257412661819833 4665 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3281 9140613 49.47 µM -1.95069504881025 0.024660726472895 no 3275 0.0255466663527745 4653 16013766
SGTC_2178 5812956 200 µM -1.96121369119055 0.0240594086582009 no 3276 0.0249270502039341 4654 5403383
SGTC_1738 st035555 74 µM -1.96510852849864 0.0238399006869719 no 3277 0.0247008388657249 4646 5331140
SGTC_2343 7990716 14.84 µM -1.96885415643073 0.0236303923661989 no 3278 0.0244849206085287 4673 6456862
SGTC_181 1447-1644 8.07 µM -1.97942349602123 0.0230475389582778 no 3279 0.0238841726377191 4639 534600
SGTC_942 3253-1115 227 µM -1.99304080414964 0.0223144936444531 no 3280 0.0231284895717552 4684 46497897
SGTC_27 0485-0001 32.618 µM -2.00152710940532 0.0218676837454151 no 3281 0.0226678076496422 4706 2054479
SGTC_504 lovastatin 124 µM -2.0031368606693 0.0217837873780164 no 3282 0.0225813002414438 4676 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_398 bronopol 33.3 µM -2.01438099189199 0.0212053197742212 no 3283 0.0219847742308911 4633 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_962 1254-0300 21.5 µM -2.02340325883243 0.0207506036507747 no 3284 0.0215157942430278 4678 7340576
SGTC_1531 st059297 52.4 µM -2.02479679673375 0.0206811117556983 no 3285 0.0214441170719894 4696 7566702
SGTC_1990 st072050 59.8 µM -2.03348856095186 0.0202521114201576 no 3286 0.0210015940505977 4690 17233948
SGTC_545 4218-0007 221 µM -2.05238600494695 0.0193453665459989 no 3287 0.0200660817726781 4694 2840508
SGTC_2080 5212524 12.4 µM -2.05537796369156 0.0192050166230457 no 3288 0.0199212561212626 4662 260183
SGTC_63 0099-0242 26.702 µM -2.05632742036121 0.0191606598222347 no 3289 0.0198754834902375 4689 3898502 YLR359W ADE13
SGTC_1642 st009582 77.7 µM -2.07431904994371 0.0183364448506229 no 3290 0.0190248448725191 4704 6739311
SGTC_2297 7971671 152.32 µM -2.09867304097686 0.0172690223109426 no 3291 0.0179228663703635 4675 909016
SGTC_2602 kawain 100 µM -2.10476795373569 0.0170103450687953 no 3292 0.0176557559960773 4675 5369129
SGTC_3257 9139206 32.98 µM -2.10927702919608 0.0168211113728579 no 3293 0.017460338181619 4717 4910041
SGTC_3329 9141233 27.5565 µM -2.12573429549282 0.0161456467703729 no 3294 0.0167626948088455 4676 4909101 YNL103W MET4
SGTC_808 0711-0032 135 µM -2.13608507503087 0.0157328291252339 no 3295 0.0163362400255555 4692 4252555
SGTC_666 0272-0154 136 µM -2.13704041285321 0.0156951880998319 no 3296 0.0162973523863637 4701 6870312
SGTC_2935 9038016 29.96 µM -2.13711364881102 0.0156923057392604 no 3297 0.0162943745443641 4664 6463195
SGTC_190 3970-0790 3.722 µM -2.14046272875646 0.0155609797375602 no 3298 0.016158694890219 4699 2832352
SGTC_584 0986-0246 15.4 µM -2.14838102884793 0.0152542290011405 no 3299 0.0158417493069348 4749 53315 YDR232W HEM1
SGTC_3225 9130819 49.47 µM -2.14951001994488 0.0152109183681439 no 3300 0.0157969963327892 4693 4547121
SGTC_1345 1488-0192 31.4 µM -2.15212419231497 0.0151110381520192 no 3301 0.0156937871096656 4738 658348
SGTC_209 4077-0173 175.592 µM -2.15228866487208 0.0151047730029002 no 3302 0.0156873130139144 4698 15993494
SGTC_1479 0549-0158 134 µM -2.15527069482689 0.0149915669333071 no 3303 0.0155703288118198 4758 5440202
SGTC_1185 1319-0113 81.3 µM -2.16364614362574 0.0146775046517087 no 3304 0.0152457586315275 4736 4672763
SGTC_948 3448-0295 75.3 µM -2.16932050148306 0.014467958766684 no 3305 0.01502917990554 4703 678569
SGTC_12 0849-0099 9.267 µM -2.17191794599758 0.0143729013411617 no 3306 0.0149309262983408 4706 6071388
SGTC_515 4092-1064 102 µM -2.18812963703349 0.0137916788422344 no 3307 0.014330080321978 4671 717353
SGTC_1171 0368-0077 21.4 µM -2.20583009123805 0.0131803415409237 no 3308 0.013697949266554 4720 3239779
SGTC_995 3931-2021 34.6 µM -2.21103836426569 0.0130049771815632 no 3309 0.0135165902493757 4706 730143
SGTC_2878 9043973 25.97 µM -2.2156444814159 0.0128515720573538 no 3310 0.0133579299712659 4703 6465167
SGTC_3029 9088683 49.47 µM -2.22172846768057 0.0126513476869929 no 3311 0.0131508307359414 4730 25236615
SGTC_454 lyso-paf C-16 6.67 µM -2.24499968112663 0.0119102013103221 no 3312 0.0123840765173726 4724 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_110 0850-0284 111.64 µM -2.26569791549251 0.0112829444056802 no 3313 0.0117349426316132 4718 3906265
SGTC_1387 3342-1166 1.8 µM -2.27141911549643 0.0111147114763416 no 3314 0.0115608091560822 4745 3418228
SGTC_383 2324-0395 7.37 µM -2.29914600003603 0.0103299443984513 no 3315 0.0107483250817687 4725 3146421
SGTC_471 1-acyl-paf 4 µM -2.31121139636783 0.01000382448781 no 3316 0.0104105905951182 4734 16759367
SGTC_3140 9094243 49.47 µM -2.33633604834765 0.00935344161328349 no 3317 0.00973686707161427 4719 19291112
SGTC_749 1000-0129 128 µM -2.33971766601776 0.00926879162795406 no 3318 0.00964916125009931 4754 708470
SGTC_640 3381-0960 37.1 µM -2.37389422749608 0.00845020112064878 no 3319 0.00880079595159713 4773 1745025
SGTC_2929 9013348 24.6 µM -2.39776193705953 0.00791682591976839 no 3320 0.00824779109928569 4731 2995952
SGTC_2299 7976368 114.88 µM -2.40606650848343 0.00773831155863817 no 3321 0.00806266436870663 4736 2979718
SGTC_2022 5136654 200 µM -2.43619563735532 0.00712004891410273 no 3322 0.0074213272612633 4725 1713771
SGTC_58 0957-0393 9 µM -2.43690474448149 0.00710603828024433 no 3323 0.00740679051362038 4313 6997992
SGTC_107 0358-0022 2.6945 µM -2.45231624768234 0.00680748654694076 no 3324 0.00709699267743657 4757 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1677 st019204 53.9 µM -2.46611383245525 0.0065496573623719 no 3325 0.00682939596613707 4750 3945625
SGTC_80 0159-0065 512.242 µM -2.47561346935597 0.00637719880494793 no 3326 0.00665037446299474 4759 1548079
SGTC_3148 9097893 49.47 µM -2.49577573513138 0.00602442729314035 no 3327 0.00628410164557018 4735 17174100
SGTC_963 1269-2853 151 µM -2.51169168719488 0.005758282742316 no 3328 0.00600770056887817 4753 3668223
SGTC_3228 9131799 49.47 µM -2.55103069708603 0.00514471691407493 no 3329 0.00537024326730365 4779 17015818
SGTC_456 gingerol 170 µM -2.55875198423106 0.00503136010237754 no 3330 0.00525243285300285 4755 442793 A herb.
SGTC_544 k015-0020 52.4 µM -2.57632889215473 0.00478156799333998 no 3331 0.00499278072351814 4779 3008304
SGTC_479 n-linoleoylglycine 10 µM -2.57680496581111 0.00477495891877391 no 3332 0.00498590988926669 4778 6433346 An anti-infammatory.
SGTC_1648 st011736 69.8 µM -2.59212058591801 0.00456664020739298 no 3333 0.00476931655423104 4774 2855514
SGTC_2258 7960471 200 µM -2.59646922312552 0.00450898911118492 no 3334 0.00470936716187674 4768 2974708
SGTC_366 0181-0206 4.31 µM -2.71643934462948 0.00315421312980192 no 3335 0.00329941427146034 4753 274874
SGTC_1168 k815-0004 80.5 µM -2.71695693812703 0.00314926397152609 no 3336 0.00329425896109273 4774 642433
SGTC_695 3505-6186 243 µM -2.72551403274112 0.00306844896772376 no 3337 0.00321007236457537 4764 1819379
SGTC_3116 9124943 49.47 µM -2.7315599147751 0.00301248144553571 no 3338 0.00315176391953879 4786 41905195 YPL160W CDC60
SGTC_571 k831-0106 44.2 µM -2.74438136726278 0.00289682403715998 no 3339 0.00303125312005345 4754 4783639
SGTC_2408 sulbentine 18.36 µM -2.75841059138665 0.00277487188433829 no 3340 0.00290415958661187 4697 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.76402322411851 0.00272739449213545 no 3341 0.00285467377784415 4766 61125 An anti-inflammatory.
SGTC_381 3461-2219 42.7 µM -2.79198818074636 0.0025015908813786 no 3342 0.00261926347850968 4776 2883159
SGTC_2883 9059145 45.46 µM -2.81086968714423 0.00235883916474433 no 3343 0.00247038961765438 4776 16476510
SGTC_1166 k206-0078 225 µM -2.82260743086483 0.00227385614555556 no 3344 0.00238174297992371 4777 5404595
SGTC_2479 5617353 43.85 µM -2.84095902955657 0.00214653428259423 no 3345 0.0022489045206754 4773 2731746
SGTC_2877 9040724 71.43 µM -2.85592116386627 0.00204755085629794 no 3346 0.00214560835720163 4770 6463895
SGTC_1743 st037606 46.3785 µM -2.89567178280624 0.00180437269057496 no 3347 0.0018917394427359 4767 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1274 0865-0114 173 µM -2.92709585097201 0.00163105942956669 no 3348 0.00171071708421365 4791 870624
SGTC_1129 3453-1384 223 µM -3.01874405284542 0.0012086220439339 no 3349 0.00126912434901498 4771 1084452
SGTC_775 4577-0580 57.3 µM -3.04686018455047 0.00110071335463404 no 3350 0.00115622622082547 4784 2006902
SGTC_1040 k898-0338 155 µM -3.15230432011611 0.000770020018660553 yes 3351 0.000809936764785009 4790 20969351
SGTC_2016 5121758 140 µM -3.15251898648304 0.000769451972323541 yes 3352 0.000809341472697699 4762 2795203
SGTC_2894 9048625 32.47 µM -3.2105898037173 0.000629208424852809 yes 3353 0.000662314358116264 4792 4092861
SGTC_369 0957-0393 4.5 µM -3.23551358689711 0.000576591575157502 yes 3354 0.000607120532156264 4789 6997992
SGTC_109 0132-0036 33.701 µM -3.68860874683912 0.000106463025287125 yes 3355 0.000112741824473451 4805 67274 A color developer.
SGTC_174 3553-0389 74.3 µM -4.31160499264063 7.59330695976672e-06 yes 3356 8.1036891434913e-06 4806 738071