SGTCid condition conc unit YPL077C|YPL077C.score YPL077C|YPL077C.strain.pval YPL077C|YPL077C.strain.significant YPL077C|YPL077C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1750 st081859 2.357 µM 15.6279964144879 5.33401511836404e-54 yes 1 2.34664893844367e-55 19 5291695 SGTC_8 0354-0001 70 µM 9.23169401291412 4.03170136735864e-20 yes 2 1.33192547113875e-20 6 4993152 SGTC_568 1193-0097 7.48 µM 7.3083133097697 2.73068759075353e-13 yes 3 1.35258225861416e-13 43 3646150 SGTC_87 0100-0052 35.5 µM 5.96641905415749 1.9498876773733e-09 yes 4 1.2125848091259e-09 32 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_18 0111-0177 500 nM 4.68442310119736 1.8945876204834e-06 yes 5 1.40374771661699e-06 42 721752 SGTC_2694 st077685 81.9 µM 4.51372167144762 4.21262757004743e-06 yes 6 3.18499015170919e-06 18 2838096 SGTC_64 000l-0018 272.079 µM 4.43085018606456 6.14833287054613e-06 yes 7 4.69311425024231e-06 125 6811119 SGTC_59 0330-0160 1.33 µM 4.3405378634804 9.21571420619642e-06 yes 8 7.10671866574336e-06 91 4293482 SGTC_644 1498-1197 63.3 µM 4.12871810915384 2.31108663643181e-05 yes 9 1.8239565078917e-05 15 6741615 SGTC_1406 3909-7906 11.9 µM 4.12047111306627 2.3932876871986e-05 yes 10 1.89049236309876e-05 7 X1406 SGTC_1048 3161-0300 24.5 µM 4.06872336719197 2.97584320016097e-05 yes 11 2.36357152910521e-05 20 2165101 SGTC_675 1309-0189 238 µM 4.05234558390558 3.18661628661813e-05 yes 12 2.53533453377324e-05 11 4246530 SGTC_1685 st024049 53.0905 µM 4.02238426627145 3.60926300333049e-05 yes 13 2.88059824009748e-05 13 1941139 SGTC_2523 spermine 47.74 µM 4.00734838601225 3.84083925594531e-05 yes 14 3.07021270918669e-05 28 1103 A DNA binding polyamine. SGTC_46 0329-0187a 2.197 µM 3.96170385387409 4.63292169558782e-05 yes 15 3.72084034807074e-05 74 46494817 SGTC_71 0417-1750 47.813 µM 3.94564673909168 4.94653251791907e-05 yes 16 3.97924375997118e-05 45 6811472 SGTC_2688 kanamycin b 96.69 µM 3.9410186487186 5.04057939586483e-05 yes 17 4.05681586460513e-05 366 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_343 4130-2827 29.8 µM 3.84240312426259 7.49415286019853e-05 yes 18 6.09177545083133e-05 36 1118244 SGTC_562 3772-2733 112 µM 3.81753390291603 8.27068921881973e-05 yes 19 6.73961345841263e-05 85 2876874 YIL048W NEO1 SGTC_1966 st070145 16.1 µM 3.77539752764783 9.76166570223448e-05 yes 20 7.98763442326037e-05 27 3748532 SGTC_1445 4239-0156 97.7 µM 3.70761917505456 0.000127003581115714 yes 21 0.000104608482864661 35 4008346 SGTC_2854 9024559 71.43 µM 3.67837848799062 0.000142087142761794 yes 22 0.000117360734809112 31 3163529 SGTC_344 k064-0035 6.43 µM 3.66024358226704 0.000152268563694512 yes 23 0.000125987799928586 29 5088750 SGTC_548 1436-0017 110 µM 3.60469507651847 0.000187868183889182 yes 24 0.000156259817475654 48 9677137 SGTC_31 0508-1974 57.237 µM 3.5495296583523 0.000230805423588 yes 25 0.000192959995352944 42 6810525 SGTC_3300 9124615 50.48 µM 3.54121542017347 0.000238019974479397 yes 26 0.00019914412537423 31 24824903 SGTC_3152 9099253 49.47 µM 3.38165661883531 0.000424431722264429 yes 27 0.000360250736123461 168 25236131 SGTC_164 4100-3994 89.624 µM 3.30185854209939 0.0005618690207399 yes 28 0.000480232474886374 64 4615967 SGTC_2277 7947813 106.88 µM 3.25811931351431 0.000653641235511008 yes 29 0.000560766205534112 53 1246798 SGTC_338 4055-0136 114 µM 3.23361624126685 0.000710912684438187 yes 30 0.000611167908869404 27 2900563 SGTC_746 1095-0025 46.6 µM 3.23028916718121 0.000719036312698909 yes 31 0.00061832536927364 39 6749286 SGTC_56 0957-0365 83.25 µM 3.21612991296106 0.000754574572683919 yes 32 0.000649659994544231 79 6752360 SGTC_1703 st026983 48.3 µM 3.21443522183864 0.000758934808312543 yes 33 0.000653507008935507 32 1104023 SGTC_1724 st037281 8.293 µM 3.19156324567647 0.000820096729560518 yes 34 0.000707525635406374 81 574124 YDL195W SEC31 SGTC_448 monastrol 171 µM 3.17677632663905 0.000862019003344474 yes 35 0.00074460921717269 24 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_78 0336-0123 156.75 µM 3.1495464715417 0.000944413370112396 yes 36 0.000817620494151603 46 6765896 SGTC_2769 toremifene 3.73 µM 3.11352880736988 0.0010645162299536 no 37 0.00092432231070656 52 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1304 1165-0502 251 µM 3.1042790170258 0.00109754267588322 no 38 0.000953716786391263 103 767425 SGTC_3235 9132602 49.47 µM 3.09202467472004 0.00114274339740126 no 39 0.000993981619655037 72 4912240 SGTC_315 k915-0449 187 µM 3.08998751908674 0.00115042076617405 no 40 0.0010008245319623 103 20970215 YNL149C PGA2 SGTC_1276 0871-0068 94.2 µM 3.06901823798089 0.00123223862765053 no 41 0.00107381739982009 48 3414906 SGTC_1228 0124-0032 52.5 µM 3.06463784465514 0.0012499884506804 no 42 0.00108966859446026 59 X1228 SGTC_3319 9138450 16.7555 µM 3.02068641448052 0.00144148083562226 no 43 0.00126101203994705 53 2029690 SGTC_3068 9116768 49.47 µM 3.01026770856334 0.00149063584151076 no 44 0.0013050875910365 62 41904888 SGTC_28 pentachloropyridine N-oxide 1.606 µM 3.00230727439387 0.00152921818668655 no 45 0.00133970785830322 133 140250 A respiratory chain inhibitor. SGTC_3043 9092303 49.47 µM 2.96556978396067 0.00171934809801602 no 46 0.00151061396961036 58 25236084 SGTC_1270 0831-1170 17.3 µM 2.95732599805236 0.00176486530388305 no 47 0.00155159919460889 52 6764716 SGTC_1948 st076329 66.6 µM 2.94475791149363 0.00183637131707582 no 48 0.00161603722277511 82 24208413 SGTC_1042 0350-0096 82 µM 2.92438130293437 0.00195791814451475 no 49 0.00172570840512107 68 3122515 SGTC_1690 st023502 41.2 µM 2.91083820669939 0.00204269769819644 no 50 0.00180230309340867 47 24207482 SGTC_1763 st044482 94.5 µM 2.90809324024099 0.00206028197583201 no 51 0.00181819949147926 62 88505 SGTC_3328 9140624 29.0385 µM 2.86045227687582 0.00238816717571447 no 52 0.00211518608977938 67 4904392 SGTC_2707 st078556 66.6 µM 2.85750137137513 0.00240995130408779 no 53 0.00213495394571292 48 17250899 SGTC_1937 st074714 47.2 µM 2.85487807221064 0.0024294677781825 no 54 0.00215266770473455 94 17250970 SGTC_1476 4112-3294 3.34 µM 2.83340297845708 0.00259469064542001 no 55 0.00230276431149967 65 704369 SGTC_2035 5154463 94.595 µM 2.81482971005528 0.00274570346847569 no 56 0.00244015434052241 80 2769623 SGTC_1920 st075728 45.7 µM 2.78496007218484 0.00300525802029413 no 57 0.00267671573785809 89 3400306 SGTC_2963 9082507 9 µM 2.77565071220504 0.00309055685280341 no 58 0.00275456795320768 83 16459611 SGTC_1058 3448-5425 97.3 µM 2.7730589122491 0.00311468956067916 no 59 0.0027766033235727 91 7279705 SGTC_3245 9134821 49.47 µM 2.77256174607158 0.00311933810913641 no 60 0.0027808483468633 82 17014901 SGTC_2214 7179297 48.276 µM 2.75613491842416 0.00327648636919559 no 61 0.00292444328370115 31 769744 SGTC_1049 3226-0134 66 µM 2.75047011450186 0.00333230811373401 no 62 0.00297549098181772 113 5702385 SGTC_3142 9086498 49.47 µM 2.74063763994406 0.00343123169346567 no 63 0.00306600463233143 94 25236367 SGTC_699 0375-0592 111 µM 2.71195925053054 0.00373500833856931 no 64 0.0033443407438865 75 762578 SGTC_277 nystatin 15.5 µM 2.70502581062365 0.00381197968330975 no 65 0.0034149541215417 93 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2585 alliin 100 µM 2.70034949942881 0.00386469343346074 no 66 0.00346333341024513 112 87310 A garlic compound which reacts with lipids. SGTC_1289 0976-0073 69.1 µM 2.68082888007713 0.00409186390515374 no 67 0.00367200298522452 77 3391136 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.67697730900532 0.00413807300045603 no 68 0.00371448330073685 76 688662 SGTC_441 propafenone 146 µM 2.67178172683758 0.00420114641363528 no 69 0.00377248541391583 42 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1414 3917-0015 5.4 µM 2.66390024504641 0.00429846836967096 no 70 0.00386202320174262 69 6618702 SGTC_1040 k898-0338 155 µM 2.63304511594785 0.00469914829580285 no 71 0.00423115528511116 92 20969351 SGTC_345 1362-0200 395 µM 2.62536791728496 0.00480388156810216 no 72 0.00432776917667439 92 1419823 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.62390712304302 0.00482404394568906 no 73 0.00434637429092006 97 5393153 SGTC_103 0844-0104 51.839 µM 2.60872122575066 0.00503815603367599 no 74 0.00454406231790092 257 5375804 SGTC_668 1682-0499 62.6 µM 2.60445272047102 0.00509984384413574 no 75 0.00460105580698951 108 682214 SGTC_1190 1486-1332 13 µM 2.59872093952988 0.0051837360842014 no 76 0.00467859037821597 91 4150046 SGTC_1132 3456-3614 2.5 µM 2.5930574518176 0.00526783272392145 no 77 0.00475634390908567 175 3125502 SGTC_91 0417-1751 58.384 µM 2.59051103497185 0.00530603815612106 no 78 0.00479167745142871 159 6795624 SGTC_1249 0481-0015 10.2 µM 2.58758224441364 0.00535028512584672 no 79 0.00483260596984786 106 4227577 SGTC_412 gemfibrozil 100 µM 2.57644660854892 0.00552152762360185 no 80 0.00499108102168656 59 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2056 5235370 200 µM 2.57255470585604 0.00558251522955869 no 81 0.00504755001197158 120 5511916 SGTC_1371 2421-0008 32.7 µM 2.56926131070243 0.00563459059274179 no 82 0.00509577871207458 147 2827552 SGTC_1364 1653-0028 37.6 µM 2.56573586609901 0.0056908127295143 no 83 0.00514785979014279 110 5718652 SGTC_2283 7944793 200 µM 2.54075096717718 0.00610373255834659 no 84 0.00553073377563229 150 2970533 SGTC_2472 5377652 49.4 µM 2.52774270217715 0.00632905383625434 no 85 0.00573992240789471 171 1610903 SGTC_1026 k007-1105 30.6 µM 2.52337944382369 0.00640626386106839 no 86 0.00581164535591957 207 7066794 SGTC_234 nsc-17383 10.7 µM 2.51366920357044 0.00658108967664811 no 87 0.00597412234349445 128 408974 SGTC_132 0417-1715 25.805 µM 2.50766377255702 0.00669131248411482 no 88 0.00607661240540389 102 6769098 SGTC_2133 5320837 200 µM 2.50692078485748 0.00670506196307226 no 89 0.00608940010567219 112 2841355 SGTC_1647 st011722 22.4 µM 2.50463562519141 0.00674750697713666 no 90 0.00612888000188209 86 2854783 SGTC_1460 k062-0059 9.15 µM 2.50240056045719 0.00678925100895497 no 91 0.00616771363146927 99 1373085 SGTC_2348 9022543 33.42 µM 2.49633055940126 0.0069037730600471 no 92 0.00627428016079884 116 3162678 YDL140C RPO21 SGTC_542 3381-0244 89.3 µM 2.46865184362213 0.00744788440378955 no 93 0.0067811549389335 137 1112843 SGTC_807 1315-0151 48 µM 2.46064860143813 0.00761209847441009 no 94 0.00693430629098688 138 4011080 SGTC_1903 st060211 78.3 µM 2.4395395700057 0.00806060982112072 no 95 0.00735299599932465 138 688960 SGTC_74 000s-0487 160.283 µM 2.42593954513788 0.00836173126341089 no 96 0.00763440676235652 129 677548 SGTC_1178 0988-0033 191 µM 2.41789645414666 0.0085444251588733 no 97 0.00780525914486126 171 5392207 SGTC_1413 3910-0535 34.4 µM 2.40153054790308 0.00892700946245853 no 98 0.00816332291263767 106 2876951 SGTC_614 0462-0418 107 µM 2.38998539291212 0.00920585061857439 no 99 0.00842452145313475 164 5188303 SGTC_2069 5228469 200 µM 2.3844458062567 0.00934232966421047 no 100 0.00855243357514674 119 2835210 SGTC_1113 artemisinin 1.17947 µM 2.3820995559898 0.00940066590127588 no 101 0.00860712144382307 108 2240 An anti-malaria and mitochondrial poison. SGTC_3320 9137005 35.139 µM 2.37430177433884 0.00959684210786821 no 102 0.0087910870154128 122 4908713 SGTC_1600 coumarin 106 71.1 µM 2.36101139607782 0.00993945458792837 no 103 0.00911258527312719 152 100336 A hepatotoxic, DNA x-linker. SGTC_1239 0337-0584 35.4 µM 2.35978971886343 0.00997147766123811 no 104 0.00914264830724832 203 914301 YML130C ERO1 SGTC_1108 betulinic acid 729.144 nM 2.35049732153322 0.010218015089151 no 105 0.00937417129740551 128 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2816 7982706 58.44 µM 2.3486865658684 0.0102666705362097 no 106 0.00941987916611695 177 2981853 SGTC_724 3910-0327 137 µM 2.33345992569886 0.0106838688911736 no 107 0.00981200962789621 141 2885483 SGTC_2518 prenyletin 46.28 µM 2.32900295104642 0.0108087469043597 no 108 0.00992945468363351 72 3873459 A coumarin with calcium channel inhibitory activity. SGTC_605 1315-0399 119 µM 2.32768904837526 0.0108458022293628 no 109 0.00996431054680523 146 24020461 SGTC_1459 k035-0031 35.7 µM 2.3201778643141 0.0110597662478079 no 110 0.0101656287695306 119 3877128 YMR208W ERG12 SGTC_3249 9135183 49.47 µM 2.31800602294981 0.0111223137367692 no 111 0.0102244968636105 138 4902779 SGTC_303 1348-1668 34.2 µM 2.31109357847297 0.0113234391788566 no 112 0.0104138433058752 110 5380509 SGTC_1842 st055362 61.2 µM 2.30949556717545 0.0113703824314252 no 113 0.0104580486910318 146 676032 SGTC_1470 k295-0292 231 µM 2.30651698263723 0.0114583329421274 no 114 0.0105408811551504 133 5045612 SGTC_2817 7995342 71.43 µM 2.29781996410669 0.0117185253277192 no 115 0.0107860190104132 131 18879975 SGTC_2959 9079155 11 µM 2.290878966218 0.011929846813349 no 116 0.0109852074129739 141 16189457 SGTC_1672 st016598 6.51 µM 2.28981108420134 0.0119626505748017 no 117 0.0110161351692912 218 4665860 YNL267W PIK1 SGTC_1989 st071868 50.2 µM 2.27803566947445 0.012329592783176 no 118 0.0113622262466788 149 16414057 SGTC_619 1652-1634 108 µM 2.27298322827256 0.0124900009040739 no 119 0.0115135953272039 145 5400454 SGTC_3248 9135562 49.47 µM 2.25936487679844 0.0129313944185948 no 120 0.0119303486691385 125 17650701 SGTC_2986 9022445 71.43 µM 2.2367186100481 0.013695279402049 no 121 0.0126523684526859 161 6459286 SGTC_726 3448-4391 34.2 µM 2.22403610119 0.0141398483243409 no 122 0.0130730077108555 175 1356692 SGTC_3137 9097352 49.47 µM 2.2187126111545 0.0143301295107151 no 123 0.0132531412547852 223 44120435 SGTC_2136 5328288 199.296 µM 2.19608366187156 0.0151637788654717 no 124 0.0140429778879181 146 262395 SGTC_2463 5473429 200 µM 2.18382388221122 0.0156325890441542 no 125 0.014487595989 156 5399405 SGTC_397 arbidol 50 µM 2.17595565599972 0.0159399750809599 no 126 0.0147792882576802 179 131410 A RNA synthesis inhibitor. SGTC_272 doxorubicin 8.13 µM 2.1749709501628 0.0159788067624599 no 127 0.014816146684812 215 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_781 4335-2806 94.4 µM 2.17131673433991 0.0161236196838624 no 128 0.0149536190970134 172 845254 SGTC_13 0199-0087 65 µM 2.16943447747719 0.0161986494666998 no 129 0.0150248569039598 148 4589825 SGTC_816 0325-0417 81.3 µM 2.16711064890956 0.0162916934368732 no 130 0.0151132090681986 151 68101 SGTC_1793 st048256 72.231 µM 2.15382545084946 0.0168324552029213 no 131 0.0156269315019842 108 672022 SGTC_1658 st012944 20 µM 2.15083898799611 0.0169561078725814 no 132 0.0157444552941088 212 24207260 SGTC_2932 9016711 44.54 µM 2.15052011689143 0.016969356308555 no 133 0.0157570482446189 234 7117328 SGTC_2468 5987765 72.9 µM 2.14755283697878 0.0170930655759479 no 134 0.0158746477538749 149 26772094 SGTC_1237 0330-0133 46.1 µM 2.14065675778308 0.0173835513756885 no 135 0.0161508640388575 167 X1237 YHR072W ERG7 SGTC_637 1181-0519 7.26 µM 2.13706640671897 0.0175364506863165 no 136 0.0162962953983078 301 6252091 YGR060W ERG25 SGTC_1193 1488-0126 41.5 µM 2.12402801088286 0.0181013975118244 no 137 0.0168339006944919 198 1384710 SGTC_976 1348-1067 47.6 µM 2.12126598758472 0.0182230456112682 no 138 0.0169497124654044 208 5310671 YGL099W LSG1 SGTC_1390 3413-2614 145 µM 2.11661037810291 0.0184296699386486 no 139 0.017146464301409 216 3421432 SGTC_1161 k007-0610 110 µM 2.11305035446641 0.0185890134438967 no 140 0.0172982291121432 325 5843850 SGTC_3340 9146634 11.102 µM 2.09698880162608 0.0193225749841494 no 141 0.017997283332278 181 4907387 SGTC_2634 4'-methoxyflavone 100 µM 2.08394631714832 0.0199362131590235 no 142 0.0185825253042135 198 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_17 0960-0276 49.807 µM 2.06939229289453 0.0206404102249706 no 143 0.0192546445786156 241 6821114 SGTC_2059 5238311 157 µM 2.06908131356666 0.0206556839750572 no 144 0.019269228467906 204 703021 SGTC_161 4065-0411 162.148 µM 2.05519541732285 0.0213475134270341 no 145 0.0199300667957567 285 1906281 YLR208W SEC13 SGTC_2052 5265182 7.135 µM 2.05366217052841 0.0214250910765111 no 146 0.0200042001682111 212 1239884 SGTC_718 1130-0073 349 µM 2.03794908922182 0.0222339530722145 no 147 0.0207775122895113 210 6740020 SGTC_1437 4092-1038 11.6 µM 2.03388408441549 0.0224473536278617 no 148 0.0209816420070883 204 3977136 SGTC_2848 9016370 25.97 µM 2.02190840159442 0.0230861057263017 no 149 0.0215929078260514 227 7894410 SGTC_3289 9119912 71.43 µM 2.0183202092849 0.023280445126608 no 150 0.021778961655179 225 17014829 SGTC_786 4544-0069 423 µM 2.01553391531022 0.0234323011933253 no 151 0.0219243680782388 243 748821 YLR208W SEC13 SGTC_300 r073-0011 5.04 µM 2.00164385807348 0.0242018127297371 no 152 0.0226615242402311 238 2735780 SGTC_135 0933-0004 26.348 µM 1.99211910241661 0.0247416634779015 no 153 0.0231789957569595 226 21230617 YGL099W LSG1 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.99198327327453 0.0247494345638778 no 154 0.0231864465858696 201 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_572 0960-0087 17.7 µM 1.98996747982612 0.0248650034428082 no 155 0.023297258983653 287 6796365 SGTC_917 harmaline 728.087 nM 1.98015475047186 0.0254340670113066 no 156 0.0238430713056898 240 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1430 4049-0248 69.1 µM 1.97842549094429 0.0255354729197317 no 157 0.0239403632035915 244 22774488 SGTC_690 glyoxal 20.3 µM 1.96995777075555 0.0260369306994157 no 158 0.024421605276592 312 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_717 1532-0246 73.2 µM 1.96955186447487 0.0260611738768698 no 159 0.0244448764816766 243 9561992 SGTC_2581 avocatin a 64 µM 1.96632069976257 0.0262548326848967 no 160 0.0246307885952772 275 6710728 A skin care supplement. SGTC_2907 7721985 69.9 µM 1.96596361806261 0.0262763078959078 no 161 0.0246514066800967 244 3267881 SGTC_979 1426-2828 121 µM 1.95754896216532 0.0267866385591787 no 162 0.0251414805888149 270 747872 SGTC_3054 9094397 49.47 µM 1.95502126053001 0.026941545137274 no 163 0.0252902804553217 271 2598354 SGTC_2094 5332512 191.667 µM 1.95298139127877 0.027067100198022 no 164 0.0254109001234735 260 755774 SGTC_180 1486-1293 102.781 µM 1.9507726735456 0.027203598189228 no 165 0.0255420469459687 252 4140536 SGTC_2208 7283366 200 µM 1.9478745738793 0.0273835704004901 no 166 0.0257149864188159 210 898663 SGTC_2085 5307070 144.047 µM 1.94091409138443 0.0278198762151424 no 167 0.0261343492516 213 2840351 SGTC_3105 9121040 49.47 µM 1.94067447653537 0.0278349985914773 no 168 0.0261488870651473 92 41448907 SGTC_1699 st031318 29.054 µM 1.94021470575487 0.0278640344465656 no 169 0.0261768010258568 219 5340658 SGTC_2771 fluoxetine 41.05 µM 1.93768490390768 0.0280242504798899 no 170 0.0263308384038515 210 3386 A selective serotonin reuptake inhibitor. SGTC_2326 6164455 177.58 µM 1.923888514229 0.0289115527434539 no 171 0.0271842796172696 230 2888790 SGTC_3203 9113543 49.47 µM 1.91582343778822 0.0294409807721645 no 172 0.0276937866879786 258 17018012 SGTC_1280 0880-0253 10.1 µM 1.91214248888659 0.0296852765200062 no 173 0.0279289601622139 246 6836607 SGTC_946 3434-1334 87.4 µM 1.90856759081175 0.0299241417030578 no 174 0.0281589480469941 233 4047976 SGTC_3198 9112019 49.47 µM 1.90781464508926 0.029974654235826 no 175 0.028207588619185 224 45595555 SGTC_3202 9113761 49.47 µM 1.9042390631068 0.0302154938317871 no 176 0.0284395282020956 325 4798415 SGTC_3011 9081274 71.4286 µM 1.90407106127645 0.0302268492279936 no 177 0.0284504650003907 277 6625322 SGTC_250 brefeldin a 552.239 µM 1.89972191252737 0.030522045351915 no 178 0.0287348115732428 174 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3236 9132701 49.47 µM 1.89966331671865 0.0305260387561806 no 179 0.0287386586309439 237 24282524 SGTC_1644 st010134 20.9 µM 1.89302981925605 0.0309809287669385 no 180 0.0291769520263244 205 3818134 SGTC_3080 9117754 49.47 µM 1.89213106881196 0.0310429896079251 no 181 0.0292367598562906 267 9550191 SGTC_749 1000-0129 128 µM 1.88398086985871 0.0316104893884897 no 182 0.0297837815773351 275 708470 SGTC_1556 plumbagin 1.48 µM 1.88135722049684 0.0317949887114578 no 183 0.0299616710368711 202 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1987 st072290 61.9 µM 1.87512914905138 0.0322365212717066 no 184 0.0303874791585397 249 54697379 SGTC_1315 1237-0019 3.69 µM 1.86558855884965 0.0329226956725872 no 185 0.03104947577767 226 825140 SGTC_2322 7413319 38.22 µM 1.86379605791659 0.0330529490916401 no 186 0.0311751747812958 470 1840400 SGTC_1318 1280-3875 124 µM 1.8633425551018 0.0330859704312908 no 187 0.0312070432692856 301 373245 SGTC_3112 9123419 49.47 µM 1.86268468951914 0.0331339205446342 no 188 0.0312533206017534 274 17015854 SGTC_355 1311-2252 105 µM 1.85989818153647 0.0333376570988382 no 189 0.0314499663409848 287 5338538 SGTC_834 0312-0008 75.7 µM 1.85843346556791 0.0334451633259823 no 190 0.0315537418014617 320 6385573 YIL048W NEO1 SGTC_1350 1495-0454 146 µM 1.85652688140571 0.0335855289095844 no 191 0.0316892475499454 299 1069057 SGTC_1859 st055998 20 µM 1.8561459064898 0.0336136348975451 no 192 0.0317163819585661 266 676301 SGTC_1694 st024011 44.9 µM 1.85049470740902 0.0340328236506964 no 193 0.0321211400788922 286 2787533 SGTC_433 pimozide 108 µM 1.84867949906613 0.0341683789727443 no 194 0.032252052833049 188 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_940 3232-1287 54.8 µM 1.84562514951461 0.0343974719547989 no 195 0.0324733261102327 265 1585493 YIL048W NEO1 SGTC_1424 4048-1941 275 µM 1.8451709291647 0.0344316485368881 no 196 0.0325063389628276 289 X1424 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.84351672464589 0.0345563505947049 no 197 0.0326268010631924 365 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_409 arachidonic acid 100 µM 1.83369347660753 0.0353045393882026 no 198 0.0333497537528927 258 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_654 1124-0271 80.9 µM 1.83361168006101 0.0353108247712208 no 199 0.0333558285925958 310 5403748 SGTC_1465 k213-0056 144 µM 1.83331193337962 0.0353338656507243 no 200 0.0333780978714738 281 24048857 YMR208W ERG12 SGTC_2473 5854593 8.94 µM 1.82433000263848 0.0360300277872659 no 201 0.0340510986081323 227 2872951 SGTC_893 0958-0369 48.9 µM 1.82343061779299 0.0361003508876213 no 202 0.0341190982798049 319 6819948 SGTC_2896 9052656 71.43 µM 1.81707894998339 0.0366001950655619 no 203 0.0346025127107842 458 6469436 SGTC_2389 9091542 195.52 µM 1.80736549111059 0.0373755325396772 no 204 0.0353526554246144 309 3626624 YOL127W RPL25 SGTC_1252 0493-0875 34.8 µM 1.80588266892383 0.0374950647234123 no 205 0.0354683343911859 290 3960963 SGTC_1633 st005664 67.9 µM 1.80497236657317 0.0375685998791797 no 206 0.0355395031599827 315 2063822 SGTC_1555 citronellol 128 µM 1.80334534710316 0.0377003254797134 no 207 0.0356669975290093 210 8842 A terpine precursor. SGTC_2236 dapsone 200 µM 1.79793042493536 0.0381414423562136 no 208 0.0360940169923831 277 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2704 st078022 71.1 µM 1.78415388031524 0.0392827247395086 no 209 0.0371993320461021 283 54697681 SGTC_3169 9102970 49.47 µM 1.77278055698695 0.0402457243223656 no 210 0.0381325381991425 223 17027839 SGTC_460 trequinsin 123 µM 1.77229144264673 0.040287564784878 no 211 0.0381730955011919 235 5537 A vasodilator. SGTC_1970 st070122 35.8 µM 1.76626104791202 0.0408063333103457 no 212 0.038676031653411 322 102928 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.76112125846539 0.0412527534699366 no 213 0.039108940825596 185 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1671 st016596 74.5 µM 1.75617600806904 0.0416860059927701 no 214 0.0395291799826409 321 2829167 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.75533554295193 0.0417600041136998 no 215 0.0396009651452583 371 65057 A dermal irritant. YDR527W RBA50 SGTC_1078 idebenone 36.1 µM 1.75153604742929 0.0420958563986851 no 216 0.0399268088230599 381 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1748 st037455 53.6035 µM 1.74757435286458 0.0424483707588729 no 217 0.0402688797993296 329 580690 SGTC_2079 5212404 121 µM 1.74732159141985 0.0424709424317878 no 218 0.0402907849193919 275 758462 SGTC_3059 1327-0034 3 µM 1.74291363470841 0.0428661373005799 no 219 0.0406743509985141 329 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1336 1486-0901 104 µM 1.73780653423464 0.0433277244478373 no 220 0.0411224544660486 297 5006114 SGTC_2074 5212007 75.395 µM 1.73775675654279 0.0433322430991072 no 221 0.0411268416426296 246 758611 SGTC_2564 betulinic acid 100 µM 1.73614422463405 0.0434788292492061 no 222 0.0412691681860028 351 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1501 4491-0275 38.4 µM 1.73584911528375 0.0435056992514518 no 223 0.0412952585283718 273 5104718 SGTC_2250 alverine citrate 130 µM 1.73031823262284 0.0440117758407045 no 224 0.041786716883124 525 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2183 6420625 130.508 µM 1.72943749388613 0.0440927999919692 no 225 0.0418654122158585 395 2897619 SGTC_115 0527-0192 112.043 µM 1.72737925968279 0.0442826175948808 no 226 0.0420497864863586 426 4233931 SGTC_309 k408-0051 1.48 µM 1.72317506049699 0.0446723901670323 no 227 0.0424284361449317 403 3640463 SGTC_3072 9116419 49.47 µM 1.72142263237317 0.0448356720848973 no 228 0.042587080139621 286 17170162 SGTC_3004 9076122 71.4286 µM 1.71872566804313 0.0450878993112186 no 229 0.0428321679648307 335 44782551 SGTC_2489 cantharidin 73.42 µM 1.71624911806417 0.0453205173415478 no 230 0.0430582283660352 386 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2165 5727197 32.143 µM 1.7161730850585 0.0453276742350083 no 231 0.0430651839078538 335 1361712 SGTC_332 4112-0506 40.9 µM 1.71602672163889 0.0453414538034189 no 232 0.0430785758706231 299 2790355 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.71214227265128 0.04570839311597 no 233 0.0434352263581245 340 5106787 A p450 inhibitor. SGTC_2272 7805186 180 µM 1.71078262565686 0.0458373929293493 no 234 0.0435606240397344 283 2956062 YPR165W RHO1 SGTC_1791 st048313 56.1 µM 1.71008733712862 0.0459034730903046 no 235 0.0436248620117816 268 1204976 SGTC_2545 solidagenone 89.61 µM 1.70980295673554 0.0459305226251149 no 236 0.0436511580430304 163 6708572 An anti ulcer agent SGTC_1360 1598-0022 39.8 µM 1.70778777996597 0.0461225681905541 no 237 0.0438378636689537 395 761525 SGTC_518 1021-0119 62.6 µM 1.70504153273963 0.0463853222622116 no 238 0.0440933393419004 349 1097762 SGTC_828 2074-0507 139 µM 1.70342142878215 0.0465408924649575 no 239 0.0442446151633261 357 X828 SGTC_3103 9120822 49.47 µM 1.70076161663038 0.046797208277407 no 240 0.0444938797750353 322 17141819 SGTC_3037 9091026 49.47 µM 1.69988462353666 0.0468819685179098 no 241 0.0445763148726786 479 25236398 YIL048W NEO1 SGTC_1851 st056236 18.9 µM 1.69806905946165 0.0470578317209235 no 242 0.0447473642131195 318 5393171 SGTC_2296 7971656 126.45 µM 1.69663643294198 0.0471969750042865 no 243 0.0448827086915815 357 666570 SGTC_291 SEC14.278 35.5 µM 1.68876473640818 0.0479674046654169 no 244 0.0456322620714916 327 1068044 SGTC_374 0880-0231 82.3 µM 1.6881133371663 0.0480316076965565 no 245 0.0456947373564614 334 6833587 SGTC_1071 trifluoperazine 6.31 µM 1.68134057569624 0.0487032253358851 no 246 0.0463483904039296 360 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_578 3460-0051 92 µM 1.67646887314207 0.0491909511445394 no 247 0.0468231941174355 376 2876744 SGTC_1522 st012842 45.6 µM 1.66799422056211 0.050048670110413 no 248 0.0476584370394401 329 3491067 YOR116C RPO31 SGTC_427 1354-0053 47.3 µM 1.66568922387719 0.0502840098725648 no 249 0.0478876647122869 356 6813657 SGTC_2587 piperic acid 92.2 µM 1.65435212306268 0.0514543902658105 no 250 0.0490279940989819 329 5370536 SGTC_2215 7188065 200 µM 1.65319749416368 0.0515747935503928 no 251 0.0491453381558042 260 940217 SGTC_638 3970-0837 4.09 µM 1.64914757195461 0.0519988862624749 no 252 0.0495587028466204 355 4118451 YLR208W SEC13 SGTC_2819 7996655 46.38 µM 1.64911081136485 0.0520027483441598 no 253 0.0495624675695301 304 6456960 SGTC_2927 9011802 47.9 µM 1.64890585259041 0.0520242855694988 no 254 0.0495834619769513 352 43912568 SGTC_253 dyclonine 31.25 µM 1.64658081003932 0.0522690992868135 no 255 0.0498221187513904 395 3180 An oral anasthetic. SGTC_1971 st069429 63.5 µM 1.64145574018958 0.0528119706220872 no 256 0.0503514236951787 300 1246522 YGL099W LSG1 SGTC_1165 k072-0275 30.3 µM 1.64131251222336 0.0528272060037527 no 257 0.0503662800554353 337 6153523 YGL055W OLE1 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.63874104453927 0.0531013306995579 no 258 0.050633601036763 376 4174840 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.63740390125403 0.053244318486396 no 259 0.0507730518045021 282 15053 SGTC_2220 6782180 200 µM 1.63233634835551 0.0537889906921182 no 260 0.0513043250158621 249 833803 SGTC_1480 1070-0044 41.2 µM 1.62241769413731 0.0548678334225753 no 261 0.0523569715351122 352 3124987 SGTC_3254 9136651 49.47 µM 1.62038247628891 0.055091302635992 no 262 0.0525750709025173 388 16454030 SGTC_3348 9149464 3.537 µM 1.61972945101272 0.0551631577258651 no 263 0.0526452034277163 346 1951442 SGTC_1768 st044301 37.178 µM 1.61710279010457 0.0554529282079658 no 264 0.0529280473585879 369 3931349 SGTC_941 3237-0776 460 µM 1.61669652430064 0.0554978541473226 no 265 0.052971902276344 336 760008 SGTC_1866 st057638 64 µM 1.61545479490527 0.0556353459905318 no 266 0.0531061211243996 336 688802 SGTC_770 0389-1121 67.2 µM 1.61210258074338 0.0560078663303802 no 267 0.0534698096279029 421 6753108 SGTC_1963 st076565 50.3 µM 1.60989262058466 0.0562545259131624 no 268 0.0537106501362649 357 4914280 SGTC_1426 4048-4480 71.7 µM 1.60859993359494 0.0563992026807685 no 269 0.0538519243890094 362 14224343 SGTC_203 k066-0004 30.888 µM 1.60752746939444 0.05651945468965 no 270 0.0539693542678384 455 6795412 SGTC_1267 0828-0272 9.49 µM 1.60226819766063 0.0571120874705641 no 271 0.0545481575105677 404 745334 SGTC_363 0455-0021 3.06 µM 1.59555988636763 0.057875089142126 no 272 0.0552935447416343 421 4597466 SGTC_1838 st055369 84.5 µM 1.59272755186267 0.0581996342759983 no 273 0.0556106619497978 329 676036 SGTC_994 3910-0338 138 µM 1.58948471618744 0.0585729707780375 no 274 0.0559755009669709 418 3479481 SGTC_2858 9025781 8.96 µM 1.58933406979035 0.058590359774935 no 275 0.0559924953980789 505 4894980 YPL153C RAD53 SGTC_2474 5321570 43.32 µM 1.58548352075301 0.0590362028661745 no 276 0.0564282590825428 342 2841384 SGTC_1423 4048-0112 5.59 µM 1.58529398364417 0.0590582173150092 no 277 0.0564497776798364 379 X1423 SGTC_1109 tnp00067 928.257 nM 1.57505768371099 0.0602567414857059 no 278 0.0576215652133345 353 676295 SGTC_3041 9091929 49.47 µM 1.56358294999068 0.0616228108162322 no 279 0.0589577707576527 403 25236887 SGTC_1848 st056003 16.4 µM 1.55825868607577 0.0622648238569688 no 280 0.0595859691402821 386 146492 SGTC_216 k038-0035 28.382 µM 1.55677646431493 0.0624444790382049 no 281 0.0597617834763719 347 4444231 YPR107C YTH1 SGTC_348 k064-0012 10.7 µM 1.55655166314178 0.0624717617053187 no 282 0.0597884838164629 349 5066323 SGTC_2801 7907800 81.82 µM 1.55624020270086 0.0625095770055757 no 283 0.0598254923920069 412 6620925 SGTC_754 3474-0146 171 µM 1.55426244326189 0.0627501190119308 no 284 0.0600609140617771 369 24762078 SGTC_815 1582-0027 36.9 µM 1.55208519386249 0.0630157571601715 no 285 0.0603209201133806 401 3128206 SGTC_2905 7799065 20.05 µM 1.55166445584525 0.0630671906907099 no 286 0.0603712658577343 341 1296806 SGTC_1298 1079-1278 263 µM 1.55158499247661 0.0630769084376882 no 287 0.0603807781793316 409 2840950 SGTC_1395 3486-0190 4.35 µM 1.5514822087381 0.063089479812818 no 288 0.0603930838522057 402 6748079 SGTC_1212 0520-0165 585 µM 1.5510803170496 0.0631386535112542 no 289 0.0604412187441651 414 5403258 SGTC_1674 st016616 23.6 µM 1.55026505529048 0.0632384970334258 no 290 0.0605389555151372 403 625830 SGTC_1952 st077036 64.1 µM 1.54541602356414 0.0638348906302117 no 291 0.0611228334740261 429 2937007 SGTC_2345 9052315 157.45 µM 1.54143623521612 0.0643276350095126 no 292 0.0616053254007602 396 6469265 SGTC_1495 4469-0029 237 µM 1.53942705106785 0.0645775157458814 no 293 0.0618500371285217 545 793680 SGTC_729 4092-0585 94.1 µM 1.53484530738664 0.0651501635308361 no 294 0.0624109153248647 365 2169061 SGTC_1740 st038286 13.222 µM 1.53330691358515 0.065343320351019 no 295 0.0626001259870252 416 716786 SGTC_978 1416-0512 87.4 µM 1.53234662071632 0.0654641172960677 no 296 0.0627184611401531 459 6814003 SGTC_2424 5537928 59.2 µM 1.53171279200756 0.0655439425680015 no 297 0.0627966621625217 453 5382802 SGTC_895 0964-0006 13.7 µM 1.5301066703941 0.0657465577300463 no 298 0.0629951637157183 387 6738897 SGTC_264 promethazine 12.5 mM 1.52982289759551 0.0657824066006233 no 299 0.0630302861213598 527 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1912 st060209 90.8 µM 1.52559713144972 0.066318039916689 no 300 0.0635551134835932 411 688787 SGTC_2701 st077767 14.721 µM 1.52032892959409 0.066990528884314 no 301 0.0642141633331349 467 5721188 SGTC_804 1595-0054 20.9 µM 1.51419025204018 0.0677807747367772 no 302 0.0649887966625899 393 761523 Stimulates phospholipase C. SGTC_2543 pimpinellin 60.67 µM 1.49945229791344 0.0697074091475187 no 303 0.0668781674699636 399 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1836 st055642 81 µM 1.49576516319748 0.0701959445075589 no 304 0.0673574312580041 444 8571 SGTC_130 0136-0219 337.655 µM 1.49482064187306 0.0703215137324557 no 305 0.0674806288302009 418 234244 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.49455652650761 0.0703566573886869 no 306 0.0675151095556937 505 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2070 5230947 200 µM 1.49117896966116 0.0708072725033032 no 307 0.0679572567718256 421 2835538 SGTC_833 3852-0053 558 µM 1.49105165001546 0.0708243020601584 no 308 0.0679739674822002 472 3123681 SGTC_1359 1582-0056 520 nM 1.49068230824956 0.0708737209333984 no 309 0.0680224615612599 478 3661189 SGTC_2336 9001819 198.65 µM 1.49022919985043 0.0709343841752312 no 310 0.0680819905671897 471 2989602 SGTC_2295 7971645 200 µM 1.48677715315667 0.0713978626868573 no 311 0.0685368387940005 444 2978226 YKL099C UTP11 SGTC_1261 0712-0010 12.7 µM 1.48658039718403 0.0714243493761769 no 312 0.0685628341737896 469 2840123 SGTC_1330 1469-0054 61.8 µM 1.48644412311402 0.0714426985959322 no 313 0.0685808431479208 430 7102664 SGTC_2933 9026794 32.47 µM 1.48465949598959 0.0716833315800241 no 314 0.0688170231691436 456 17586027 SGTC_686 1319-0111 510 µM 1.48390928480734 0.0717846729043446 no 315 0.0689164941709392 459 4562600 SGTC_567 1080-0542 68.4 µM 1.48381899936724 0.0717968764026883 no 316 0.0689284726458228 387 5950415 SGTC_2989 9073649 71.4286 µM 1.48255034586593 0.0719685232035075 no 317 0.0690969589629549 533 21367202 SGTC_1122 capsaicin 818.572 nM 1.47744900415439 0.0726619043050337 no 318 0.0697776592508262 424 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2016 5121758 140 µM 1.47703813506376 0.0727179720276784 no 319 0.0698327075982195 485 2795203 SGTC_2926 9010726 65.15 µM 1.47653066689955 0.0727872675041743 no 320 0.0699007444416982 450 2994293 SGTC_1433 4060-0023 7.6 µM 1.47202657511609 0.0734045249943084 no 321 0.0705068506793583 436 3840627 SGTC_2365 9042475 200 µM 1.47149061413473 0.0734782408281167 no 322 0.0705792419819904 463 6464479 SGTC_41 0478-0632 82.643 µM 1.4708115774796 0.0735717165078626 no 323 0.0706710402863021 517 3750424 SGTC_3056 9094900 49.47 µM 1.46850493212927 0.0738899266831227 no 324 0.0709835587495083 439 25236784 SGTC_2186 6124449 200 µM 1.4675261947839 0.0740252644714792 no 325 0.0711164844040421 410 3834182 YLR033W RSC58 SGTC_2413 inermin 26.06 µM 1.46419421221528 0.0744874242214723 no 326 0.0715704455904332 475 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2486 5283202 22.39 µM 1.46087747424836 0.0749496538202936 no 327 0.0720245347117908 444 1377751 SGTC_2237 6667747 47.222 µM 1.45925325597757 0.0751768058298772 no 328 0.0722477078937749 407 729940 YDL015C TSC13 SGTC_1353 1498-1206 8.11 µM 1.45880902522563 0.0752390242146344 no 329 0.072308838929107 516 6756808 SGTC_2444 5485484 36.41 µM 1.45413040707086 0.0758966914409803 no 330 0.0729550773780586 464 6790631 SGTC_1985 st071382 65.5 µM 1.44843236768842 0.0767035589434341 no 331 0.0737480839882574 439 6123237 SGTC_1965 Pectolinarigenin 58.4 µM 1.43343836050087 0.0788579327512142 no 332 0.075866301179801 443 5320438 An anti-inflammatory. SGTC_3286 9117135 37.221 µM 1.43275748319966 0.0789568399688832 no 333 0.0759635778098477 461 3438150 SGTC_2354 9060492 162 µM 1.43115138071607 0.0791905216702653 no 334 0.0761934171485629 513 6471895 SGTC_1623 st003709 20.3 µM 1.42920635552521 0.0794742159376004 no 335 0.0764724657713172 538 16192618 SGTC_803 4488-1585 147 µM 1.4281099573288 0.0796344711848295 no 336 0.0766301059639637 423 747204 SGTC_3113 9123498 49.47 µM 1.42777049868428 0.0796841377538759 no 337 0.0766789634177041 440 8897275 SGTC_1579 chlormadinone acetate 49.4 µM 1.42707807744501 0.0797855193150134 no 338 0.0767786953526563 476 45114258 A steroidal progestin. SGTC_1762 st045503 25.4615 µM 1.42680947763882 0.0798248728820443 no 339 0.0768174092933692 471 4645554 SGTC_1199 1638-0010 4.46 µM 1.41583765903165 0.0814449722831089 no 340 0.0784115204006549 505 3111136 SGTC_1933 st074711 15.9 µM 1.41247655125192 0.0819462027392835 no 341 0.0789048451477425 514 17250958 SGTC_2262 9014885 67.46 µM 1.4096935032323 0.0823629854039322 no 342 0.0793151019561624 367 6457424 SGTC_194 1486-1323 56.904 µM 1.40760595555313 0.0826766577984129 no 343 0.0796238914861968 471 5178754 SGTC_1326 1431-2094 10.8 µM 1.40380658575371 0.0832498523479189 no 344 0.0801882261685109 501 616278 SGTC_1294 1000-1494 117 µM 1.40113837367081 0.0836541763906914 no 345 0.0805863492154497 471 712797 YDL207W GLE1 SGTC_643 k048-0106 28.4 µM 1.39948023397844 0.083906182675175 no 346 0.0808345108011823 478 6763920 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.3950684377892 0.0845794693691175 no 347 0.0814976014055191 526 5379071 SGTC_2226 7298446 200 µM 1.38831336229647 0.0856182062884398 no 348 0.082520822527852 409 3283010 SGTC_2571 chrysanthemic acid 100 µM 1.38738809544942 0.0857612263804017 no 349 0.0826617265347267 454 2743 An insecticide. SGTC_1516 st013856 110 µM 1.38623156676339 0.0859402443910522 no 350 0.0828381027058241 454 5281404 A mutagen and neurotoxin. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.3836053515376 0.0863477920643278 no 351 0.0832396643966336 448 616764 SGTC_694 1315-0438 43.2 µM 1.38250959842965 0.0865182625324091 no 352 0.083407642678857 416 6793154 SGTC_964 1287-0107 19.4 µM 1.38215976379238 0.0865727405850852 no 353 0.0834613257371672 536 51516812 YPR165W RHO1 SGTC_3019 9081971 49.47 µM 1.38184218468454 0.0866222178414534 no 354 0.0835100815813086 518 16451803 SGTC_2154 5570129 200 µM 1.37669503500231 0.0874270680576326 no 355 0.084303277217056 529 673366 SGTC_3174 9107204 49.47 µM 1.37665188180917 0.0874338393569653 no 356 0.0843099511075816 488 3938802 SGTC_1550 gossypolone 36.6 µM 1.37585838164632 0.0875584196756929 no 357 0.0844327411766467 507 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_79 0052-0007 94.094 µM 1.37462892788405 0.0877517066915517 no 358 0.0846232577560852 494 2801472 SGTC_1634 st006576 41 µM 1.3733364519505 0.0879552446615387 no 359 0.0848238877325985 486 3915356 SGTC_2037 5169046 200 µM 1.37221345164552 0.0881323794169198 no 360 0.0849984995293297 463 5718022 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.36755205509127 0.0888704812822813 no 361 0.0857261663309919 534 2333 A French combination drug. SGTC_148 3253-0744 288.01 µM 1.35887315858101 0.0902569734067641 no 362 0.0870933928447793 478 6893655 SGTC_138 0850-0259 40.9225 µM 1.35715948285992 0.090532629897338 no 363 0.0873652708059508 650 6813004 SGTC_1105 epirubicin 18.1 µM 1.35324684448889 0.0911643463259674 no 364 0.0879883922248019 500 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_738 1315-0003 72.4 µM 1.35145888786199 0.0914541072779522 no 365 0.0882742404924748 541 6251474 SGTC_2797 7859098 81.82 µM 1.35059383836711 0.0915945442611282 no 366 0.0884127878363737 523 972681 SGTC_1689 st020265 53.493 µM 1.35022431505313 0.0916545834346627 no 367 0.0884720204898418 506 5758320 YPR016C TIF6 SGTC_1216 1165-0504 9.65 µM 1.3496722229916 0.0917443402181418 no 368 0.0885605730364876 527 6304004 SGTC_3031 9088762 49.47 µM 1.34850666907966 0.0919340448445158 no 369 0.088747738313428 517 205253 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.34758501557405 0.0920842579922194 no 370 0.0888959463656359 502 6312947 SGTC_732 3970-1727 52.7 µM 1.34670197262781 0.0922283486891026 no 371 0.0890381183571574 482 1275699 SGTC_620 0109-0052 432 µM 1.3439867875864 0.0926724449613655 no 372 0.0894763297168291 512 493037 SGTC_628 1636-0253 16 µM 1.34329832713777 0.092785300656732 no 373 0.0895876967879618 544 4456143 SGTC_1954 st077032 68.9 µM 1.3379274855337 0.0936692053709163 no 374 0.0904600381706535 470 698907 SGTC_2053 5265679 138 µM 1.33560364374112 0.0940535720654002 no 375 0.0908394292697055 551 764595 SGTC_1327 1436-0082 2.18 µM 1.3313797844686 0.0947551821653802 no 376 0.0915320388596454 510 15992205 SGTC_2760 etidronate 98.04 µM 1.33040158366 0.0949182162496178 no 377 0.0916929965384417 510 3305 A chelator and antioxidant. SGTC_1172 0370-0043 85 µM 1.32878630101092 0.0951878832805008 no 378 0.0919592414911208 499 376585 SGTC_1817 st052116 64.4 µM 1.32832436608471 0.0952651056984097 no 379 0.0920354867980597 497 4361398 SGTC_664 1222-0054 14.9 µM 1.3242053296775 0.0959557321338664 no 380 0.0927174306413426 543 6813991 SGTC_16 erodoxin 22.806 µM 1.32266906408534 0.0962142536474768 no 381 0.092972727838093 603 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_224 benfluorex 43.875 µM 1.32158174894738 0.0963975353182516 no 382 0.0931537320803359 413 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1015 4130-4525 82 µM 1.32103386432875 0.0964899858320996 no 383 0.0932450364850665 536 1363237 SGTC_534 k292-0788 63.4 µM 1.3209053083096 0.0965116879164619 no 384 0.0932664697874666 588 4146317 SGTC_3279 9140807 49.47 µM 1.32022244318578 0.096627025380112 no 385 0.0933803804375919 512 45595718 SGTC_599 1935-0052 86.5 µM 1.31894635718588 0.0968428305182238 no 386 0.093593523348116 554 9557311 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.31756811064079 0.0970763098311727 no 387 0.0938241333104136 573 1377 SGTC_3197 9113331 49.47 µM 1.31733992815845 0.0971150044930709 no 388 0.0938623535264702 542 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1619 st003326 88.7 µM 1.31691706739054 0.0971867421761644 no 389 0.0939332124355167 494 2849032 SGTC_1907 st060210 83.7 µM 1.31508171247287 0.0974985580327312 no 390 0.0942412209816495 584 688793 SGTC_785 1270-0111 65.3 µM 1.31499860971711 0.0975126940392429 no 391 0.0942551848619578 524 6741994 SGTC_237 nikkomycin 200 µM 1.31420221718001 0.0976482388252181 no 392 0.0943890812883707 558 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_499 genistein 192 µM 1.31416180823 0.0976551200472782 no 393 0.0943958789289681 472 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1632 st005650 90 µM 1.30983033995711 0.0983947870315708 no 394 0.0951266184311171 524 2759605 SGTC_114 0364-0001 490.298 µM 1.30891918034607 0.098550902922469 no 395 0.0952808643872893 558 4003655 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.30741768230272 0.0988085614760188 no 396 0.0955354476121023 588 1273210 SGTC_912 3474-0017 2.18 µM 1.30731096514881 0.0988268929906028 no 397 0.0955535608426851 553 3360550 SGTC_683 panaxydol 45 µM 1.30722189842489 0.0988421944786931 no 398 0.0955686801793893 571 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1003 4049-0218 100 µM 1.30621391536167 0.0990154848250857 no 399 0.0957399109699217 573 295161 SGTC_84 0443-0269 128.823 µM 1.30326124852912 0.0995243799376196 no 400 0.0962427930427998 549 6150058 SGTC_655 k060-0012 42 µM 1.29819921810032 0.100401269060761 no 401 0.0971094433751655 553 5994525 SGTC_2024 5144227 134 µM 1.28893986005839 0.102019819547179 no 402 0.0987094975952305 594 3475211 SGTC_3341 9147222 25.867 µM 1.28392454323045 0.102904392086815 no 403 0.0995841793601082 526 1939759 SGTC_184 1494-0393 24.714 µM 1.28132688651644 0.103364736249662 no 404 0.100039436471683 578 3090647 SGTC_2095 5432005 200 µM 1.27913175767582 0.10375491030998 no 405 0.100425330987726 508 783734 SGTC_2915 7971052 15.16 µM 1.2689337818759 0.105581568053412 no 406 0.102232341207893 409 5741558 SGTC_1148 3909-7663 27.7 µM 1.26433733881887 0.106412441120919 no 407 0.103054486564556 575 4084526 SGTC_204 PMA1.184 62.41 µM 1.26399555445196 0.106474411609665 no 408 0.103115811289162 621 2252213 YGL008C PMA1 SGTC_2335 9018011 154.17 µM 1.26032678973013 0.107141253628559 no 409 0.103775749812059 614 6458208 SGTC_1392 3455-1037 33.9 µM 1.256907444181 0.107765467497221 no 410 0.104393576315733 582 981132 SGTC_2796 7949634 45.45 µM 1.25438436487143 0.108227741487643 no 411 0.10485116636015 554 2971588 SGTC_1361 1608-0041 5.61 µM 1.25168360735125 0.108724149080188 no 412 0.105342587820288 587 X1361 SGTC_52 0329-0193 875 nM 1.24775684022254 0.109448818779546 no 413 0.106060059346152 577 3739292 SGTC_685 1278-0033 54.9 µM 1.24534934736936 0.109894824123482 no 414 0.106501681856347 611 3590572 SGTC_577 r071-0003 38.6 µM 1.24378204607093 0.110185878012033 no 415 0.106789894956429 731 4568517 YMR134W ERG29 SGTC_2662 daunorubicin 22.37 µM 1.24308275836879 0.110315916659657 no 416 0.106918669307615 542 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1340 1486-1359 257 µM 1.24010242682838 0.110871369318897 no 417 0.10746875573837 606 4309068 SGTC_375 3970-0961 9.27 µM 1.23859730042045 0.111152644113013 no 418 0.107747334169838 590 2898222 SGTC_3082 9117008 49.47 µM 1.23659365126876 0.111527874094044 no 419 0.108118989037188 595 41448529 SGTC_2786 7743617 45.45 µM 1.23646925286037 0.111551200443072 no 420 0.108142093963085 511 583674 SGTC_198 3454-2873 16.191 µM 1.23582605067227 0.111671865061213 no 421 0.108261614723925 587 710957 SGTC_1775 st081588 35.1725 µM 1.23481670812846 0.111861405730961 no 422 0.108449363821682 634 1426443 YGL099W LSG1 SGTC_2116 5511452 16.8835 µM 1.23466375655569 0.111890147997615 no 423 0.108477834966166 604 870744 SGTC_1300 1094-0077 113 µM 1.23450316420535 0.111920331782761 no 424 0.108507734188634 548 5532636 SGTC_3187 9109394 49.47 µM 1.23286895922995 0.11222781634869 no 425 0.108812329055094 606 17098090 SGTC_331 k048-0133 24.5 µM 1.23020568356434 0.112730219051722 no 426 0.109310046048867 534 6813582 SGTC_2715 st079500 56.4 µM 1.2294942477768 0.112864696316423 no 427 0.109443276610386 555 28246688 SGTC_3098 9119039 49.47 µM 1.22879198524588 0.112997551907383 no 428 0.109574903639558 599 17161528 SGTC_246 cycloheximide 667 µM 1.2246297718159 0.113787260117841 no 429 0.110357372657312 529 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2669 eugenol 100 µM 1.22134476485013 0.114413305020868 no 430 0.110977755522422 539 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1993 st073995 70.8 µM 1.22081369459709 0.114514744310818 no 431 0.111078283748614 617 3098394 SGTC_2951 9072950 58.06 µM 1.21566040400663 0.115502395565918 no 432 0.112057156824602 645 16488155 SGTC_902 1120-0002 2.07 µM 1.21427672001364 0.115768612523575 no 433 0.112321036172405 632 3280475 SGTC_2787 5284540 71.43 µM 1.21265944372488 0.116080323974182 no 434 0.11263002583917 593 736958 SGTC_377 3970-0964 33.1 µM 1.20923877799055 0.116741579489844 no 435 0.113285561883947 710 16481235 SGTC_471 1-acyl-paf 4 µM 1.20879270494714 0.116828007178205 no 436 0.113371247472693 602 16759367 SGTC_3159 9100096 49.47 µM 1.20755581058084 0.117067895556984 no 437 0.11360908266184 598 25236875 SGTC_26 0302-0163 425.158 µM 1.20743651724982 0.117091050236579 no 438 0.113632039673315 616 3100915 SGTC_1960 st011366 51.8 µM 1.20735953128102 0.117105994835119 no 439 0.113646856739755 598 3972846 SGTC_265 mycophenolic acid 32.932 µM 1.20578217115482 0.117412491214649 no 440 0.113950745838173 671 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_926 2268-1401 59.4 µM 1.20024948980286 0.118492033994728 no 441 0.115021230033197 627 2931578 SGTC_756 0508-1999 28.3 µM 1.19878267978259 0.11877941232015 no 442 0.115306229512953 599 6753853 SGTC_2756 carbadox 75.1 µM 1.19700339012442 0.119128672242057 no 443 0.115652616689838 637 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_523 1934-0222 13.7 µM 1.19220745381223 0.120073683852912 no 444 0.116589955732896 630 1361595 SGTC_1833 st055984 71 µM 1.19180578663878 0.120153069150101 no 445 0.116668703143603 618 676288 SGTC_3173 9105693 49.47 µM 1.18831993141062 0.120843565224385 no 446 0.117353694054248 658 17096658 SGTC_158 k038-0087 26.446 µM 1.18828657085956 0.120850186916982 no 447 0.11736026332779 747 X158 SGTC_3290 9121031 71.43 µM 1.18583236106631 0.121338020394118 no 448 0.117844254464295 566 17014854 SGTC_2148 5546263 113.568 µM 1.18237248358346 0.122028104075326 no 449 0.11852896820348 617 792097 SGTC_3151 9099821 49.47 µM 1.1819622640858 0.122110106077814 no 450 0.118610337173471 607 17174189 SGTC_2840 9008771 71.43 µM 1.1804480447489 0.12241313028093 no 451 0.118911031430792 588 2992978 SGTC_192 3455-0609 60.9 µM 1.17955717139013 0.122591657431646 no 452 0.119088192742975 623 3769639 SGTC_1611 st001856 99.4 µM 1.17750188644229 0.123004224199456 no 453 0.119497622513508 606 647478 SGTC_957 1187-1561 14.1 µM 1.1769191805842 0.123121370316069 no 454 0.119613882817798 645 1538454 SGTC_301 4119-0100 24.5 µM 1.17586338302843 0.123333825073079 no 455 0.119824736616889 690 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2047 4141938 200 µM 1.1729176899706 0.123927935013699 no 456 0.120414407431532 584 3807862 SGTC_2198 6589944 200 µM 1.17275809412286 0.123960180628803 no 457 0.120446413700045 543 5290268 SGTC_1897 st060201 15 µM 1.17228447703514 0.12405590737347 no 458 0.120541430864252 605 611878 SGTC_2878 9043973 25.97 µM 1.1722536522434 0.124062139424463 no 459 0.120547616769641 610 6465167 SGTC_845 0330-0138 4.51 µM 1.1685689649535 0.124808675586902 no 460 0.121288669142286 640 9039800 SGTC_1068 loratadine 26.9 µM 1.1679183319239 0.124940822504212 no 461 0.121419854418053 619 3957 A H1 histamine antagonist. SGTC_120 rhodamine 6G 52.259 µM 1.16670914514156 0.12518667412701 no 462 0.121663924190908 745 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_563 tetrahydrosecaminediol 614 µM 1.16523021090936 0.125487829746681 no 463 0.121962909921503 677 334274 A psychoactive constituent of the cannabis plant. SGTC_2665 lovastatin 100 µM 1.16512952993769 0.125508349795746 no 464 0.121983282630746 633 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1466 k213-0079 57.5 µM 1.15542948621575 0.127496330740642 no 465 0.123957296464002 672 3657981 SGTC_1204 4049-0315 18.3 µM 1.15459755210962 0.127667845788699 no 466 0.124127634787917 647 588402 SGTC_673 1082-0474 110 µM 1.15334846013658 0.127925664946755 no 467 0.124383693505486 761 3098046 SGTC_1653 st012112 65 µM 1.15270085582939 0.128059476190086 no 468 0.124516595027021 630 720429 SGTC_3109 9122853 49.47 µM 1.15093249379897 0.128425359123421 no 469 0.1248800043003 703 1234709 SGTC_2708 st078559 56 µM 1.15087014860925 0.128438271884457 no 470 0.124892830129718 545 17250902 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.14973092699374 0.128674382982782 no 471 0.125127356101449 653 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2777 climbazole 1.536 µM 1.14854113955948 0.128921295521004 no 472 0.125372619963186 689 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_743 1275-0778 158 µM 1.14541701103201 0.129571198880421 no 473 0.12601822747198 711 2849257 YMR203W TOM40 SGTC_116 0155-0182 31.788 µM 1.14532009598213 0.129591396065844 no 474 0.126038292165426 792 771486 SGTC_962 1254-0300 21.5 µM 1.14224180850011 0.130234048956071 no 475 0.126676761000155 662 7340576 SGTC_387 norethindrone acetate 66.7 µM 1.14067653550285 0.130561674701209 no 476 0.127002277289333 632 541197 SGTC_2969 9091408 28.7 µM 1.14016094879491 0.130669716320185 no 477 0.12710962675076 636 4286311 SGTC_1940 st075990 51.1 µM 1.13796575389175 0.131130412958476 no 478 0.127567391307213 732 1084979 SGTC_147 4466-0538 29.23 µM 1.13773147857889 0.131179645544368 no 479 0.127616312402758 690 6742687 YHR072W ERG7 SGTC_2685 mycophenolic acid 18.85 µM 1.13750264552397 0.13122774677264 no 480 0.127664109642764 635 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2659 sanguinarine 24.21 µM 1.13689084305877 0.131356408856915 no 481 0.127791960283696 662 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2647 atorvastatin 60.16 µM 1.13619772911559 0.131502275952364 no 482 0.127936910365737 660 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1335 1486-0900 202 µM 1.13555318056714 0.131638022673845 no 483 0.128071806498344 699 X1335 SGTC_2837 9008476 45.46 µM 1.13415623307865 0.131932562048575 no 484 0.128364509561024 677 2992805 SGTC_2629 bisabolol 100 µM 1.13352076867815 0.132066696840399 no 485 0.128497812286016 709 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.13156967103914 0.132479124998308 no 486 0.128907698485571 723 688801 SGTC_574 1315-0397 40 µM 1.13151746046562 0.132490173585429 no 487 0.128918679316156 766 6794277 SGTC_1489 4065-0444 182 µM 1.13132243765039 0.132531449127576 no 488 0.128959701888884 659 2877968 SGTC_472 calcifediol 10 µM 1.13031393920982 0.132745033821643 no 489 0.129171981516147 608 5283731 A vitamin D metabolite. SGTC_2753 fluvastatin 17.09 µM 1.12992868648116 0.13282668705705 no 490 0.129253137573463 688 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2809 7964133 12.99 µM 1.12964533749559 0.132886764149149 no 491 0.129312849479044 690 1253665 SGTC_2481 5478948 45.16 µM 1.12723788377691 0.133397959523478 no 492 0.129820958594229 651 77792 SGTC_244 nsc-207895 1.295 µM 1.12338355623881 0.134219195500587 no 493 0.130637315264399 558 42640 SGTC_2874 9043904 71.43 µM 1.12242871608227 0.134423177461981 no 494 0.130840100270083 576 4463428 SGTC_1696 st025591 34.7925 µM 1.12004573808912 0.134933179798731 no 495 0.131347135916718 706 2787147 SGTC_2691 st077356 60.2 µM 1.11691852173081 0.135604474711977 no 496 0.132014582243048 718 2839272 SGTC_931 2812-0076 566 µM 1.11677150131091 0.135636090641401 no 497 0.132046018489261 719 3450959 SGTC_2709 st078560 56 µM 1.11590433349137 0.135822673020155 no 498 0.132231543336996 698 17250903 SGTC_1471 k673-0312 37 µM 1.11484947543211 0.136049876234302 no 499 0.132457465415509 682 24099884 SGTC_3155 9099265 49.47 µM 1.11256440499351 0.136542943597026 no 500 0.132947777489523 653 25236499 SGTC_129 0088-0017 176.636 µM 1.11134661527203 0.136806214124967 no 501 0.133209590813014 667 182446 SGTC_2843 9000894 45.46 µM 1.11017298285764 0.137060266555167 no 502 0.133462246252358 553 2242070 SGTC_2254 7938975 95.19 µM 1.10422462790216 0.138352843321857 no 503 0.134747854442068 788 2969277 SGTC_1457 k015-0032 57.3 µM 1.10407733077182 0.138384956041271 no 504 0.134779796980542 702 4302660 SGTC_3076 9116187 49.47 µM 1.10097452652785 0.139062589056649 no 505 0.135453872005693 641 27241210 SGTC_2869 9037858 32.47 µM 1.098482904764 0.13960837620042 no 506 0.135996839244912 653 27187042 SGTC_2814 7977482 42.97 µM 1.0964038230809 0.14006491029531 no 507 0.13645104582274 773 6456762 SGTC_938 3126-1755 342 µM 1.09552480285608 0.140258234252356 no 508 0.136643392718763 749 1777771 SGTC_2043 5101342 149 µM 1.09268961324183 0.140883015390933 no 509 0.137265050865732 692 678451 SGTC_2663 amphotericin b 100 µM 1.08766162346054 0.141995653431551 no 510 0.13837225770647 668 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2459 5811157 9.22 µM 1.0848617055218 0.142617815899036 no 511 0.1389914554709 705 2870684 YBR192W RIM2 SGTC_2340 7987427 183.45 µM 1.08437831831456 0.142725414416633 no 512 0.139098546497337 708 2239331 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.08434769099678 0.142732233685696 no 513 0.139105333655034 523 4000243 SGTC_2710 st078562 53.7235 µM 1.08363668775463 0.142890602714592 no 514 0.139262958675945 712 17250908 SGTC_759 3486-0358 89.3 µM 1.08185716039771 0.143287495471588 no 515 0.139658001477318 785 875103 SGTC_1183 1254-0324 198 µM 1.08019044359849 0.143659902375245 no 516 0.140028691515906 734 5799357 SGTC_872 0588-0139 234 µM 1.07896997966809 0.143933013605932 no 517 0.14030055528629 740 2047100 SGTC_2965 9082772 38.63 µM 1.0783885932303 0.144063237340199 no 518 0.140430187670209 762 16459634 SGTC_259 usnic acid 108.925 µM 1.07763520587331 0.144232105413817 no 519 0.140598292228517 745 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3315 9136395 68.55 µM 1.07619899594593 0.144554394341086 no 520 0.140919134355954 787 16876844 SGTC_1075 aripiprazole 15.2 µM 1.07551647892345 0.144707722729538 no 521 0.141071779209171 777 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1009 4106-0057 9.87 µM 1.0754221929092 0.144728912820584 no 522 0.141092875077087 773 2928005 SGTC_2445 5742597 35.57 µM 1.07451423121855 0.144933077520163 no 523 0.141296134951627 688 1774255 SGTC_2111 5486399 200 µM 1.07438654132965 0.144961805473831 no 524 0.141324736024549 783 689674 SGTC_347 4534-1311 26.2 µM 1.07392801927839 0.145064996375701 no 525 0.141427472058511 720 2862016 SGTC_2558 carylophyllene oxide 100 µM 1.07367329585336 0.145122343525418 no 526 0.141484567020987 776 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3295 9122362 53.5725 µM 1.07326509055807 0.145214276623541 no 527 0.141576096732546 689 4730473 SGTC_488 nitrendipine 139 µM 1.07177819755245 0.145549475392796 no 528 0.141909834024633 774 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2313 7726885 200 µM 1.07140747284931 0.145633130948301 no 529 0.141993127116296 711 726423 SGTC_532 1548-0774 215 µM 1.0705347918667 0.145830182600364 no 530 0.142189328568897 755 5932993 SGTC_802 4112-3352 742 µM 1.0690819102837 0.146158641082178 no 531 0.142516381062027 781 704594 SGTC_3214 9129694 49.47 µM 1.0685407539264 0.146281109277639 no 532 0.14263832859433 696 17158655 SGTC_49 0717-0965 32.132 µM 1.0677895891276 0.146451218316291 no 533 0.142807717640925 742 5889349 YGL099W LSG1 SGTC_447 ml7 120 µM 1.06499349412541 0.147085589749725 no 534 0.143439436929689 755 4216 Selective myosin light chain kinase inhibitor. SGTC_1492 4158-0558 28.5 µM 1.05754330567359 0.148784854177713 no 535 0.145131850703018 732 3967268 SGTC_2006 4011487 200 µM 1.05722038843072 0.148858801721166 no 536 0.145205508452549 768 45595294 SGTC_3287 9117173 37.0625 µM 1.05672402629298 0.148972515755606 no 537 0.145318778200178 701 2789709 SGTC_2512 diallyl trisulfide 49.23 µM 1.0538162599007 0.149639835791975 no 538 0.145983523840684 709 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2897 9048598 12.99 µM 1.0531258114271 0.149798583362203 no 539 0.146141667238996 696 6467404 SGTC_937 3122-0005 46.7 µM 1.05094061445113 0.150301742900872 no 540 0.146642932688516 801 759535 SGTC_1641 st009299 47.1 µM 1.04504400259325 0.15166510030423 no 541 0.148001316466378 692 4046054 SGTC_2968 9090663 33.37 µM 1.04493083041706 0.151691347016388 no 542 0.148027469690039 752 25236811 SGTC_1151 3909-8316 15.3 µM 1.04345685111575 0.152033465654904 no 543 0.14836837750949 759 800431 SGTC_1787 fluconazole 80 µM 1.04317203466651 0.152099632141377 no 544 0.148434311486219 793 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1153 4055-0057 267 µM 1.04309170975863 0.15211829609652 no 545 0.14845290995351 772 882706 SGTC_1552 6-methylflavone 10.6 µM 1.04136437590365 0.152520020070656 no 546 0.148853234748593 725 689013 SGTC_2327 6189656 200 µM 1.0395274696114 0.152947998855131 no 547 0.14927974469682 759 5349088 SGTC_2168 5727979 200 µM 1.03932919741851 0.152994241639634 no 548 0.149325830116999 683 695210 SGTC_2954 9074818 52.69 µM 1.03753952740661 0.153412063602994 no 549 0.149742242071571 737 16648742 SGTC_2536 dehydroabietamide 32.04 µM 1.03749956000757 0.153421403137327 no 550 0.14975155033143 810 3983547 SGTC_2411 st077133 39.94 µM 1.0371523902082 0.153502545207814 no 551 0.149832421135795 817 1403142 YNL221C POP1 SGTC_1198 1612-1005 86.7 µM 1.0362775093709 0.153707152290367 no 552 0.150036347754474 787 6998509 SGTC_1347 1493-0251 600 nM 1.03478683536345 0.154056189727909 no 553 0.150384236135497 833 3986378 SGTC_881 0833-0569 170 µM 1.03470224988037 0.154076010907502 no 554 0.150403992505865 760 5418700 SGTC_3106 9121286 49.47 µM 1.03457155803493 0.154106639651613 no 555 0.150434521196947 708 15943471 SGTC_3170 9103054 49.47 µM 1.03307663527607 0.15445727401814 no 556 0.150784018260561 710 16432970 SGTC_1839 st053978 48 µM 1.03283077506911 0.154514991029635 no 557 0.150841549488699 769 3788398 SGTC_550 4123-0385 25.7 µM 1.0298472230896 0.155216532048085 no 558 0.151540864453408 745 5731123 SGTC_278 4092-0821 23.9 µM 1.0269406352388 0.155901994781361 no 559 0.152224209252588 782 877900 SGTC_2864 9034755 47.6 µM 1.02458445059327 0.156459117808086 no 560 0.152779652253841 792 4930451 SGTC_1588 farnesol 29.9 µM 1.02297956871383 0.156839343978719 no 561 0.153158753044373 783 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2921 7974240 10.71 µM 1.02144904704508 0.157202518786765 no 562 0.153520868949976 757 2979074 YDR527W RBA50 SGTC_2084 5306078 60.6385 µM 1.02075411745732 0.15736759980532 no 563 0.153685473803547 754 679340 SGTC_2784 7567673 72.73 µM 1.01959220623153 0.157643867094546 no 564 0.15396095141654 807 3471247 SGTC_2566 crystal violet carbinol 226 nM 1.0180799500293 0.158003912755662 no 565 0.154319981427749 645 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2384 9036245 200 µM 1.01582358890423 0.15854212159991 no 566 0.154856700436459 812 6462766 SGTC_2767 sibutramine 71.45 µM 1.0154515177771 0.158630986907384 no 567 0.154945323017049 817 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.00595946159919 0.160909108317591 no 568 0.15721753548238 746 6708760 SGTC_889 0919-1524 82.7 µM 1.00391092482751 0.161403551315057 no 569 0.157710775124097 742 3905452 SGTC_2045 5106652 78.05 µM 1.00335279788532 0.161538434624505 no 570 0.157845335022579 815 673349 SGTC_2929 9013348 24.6 µM 1.00331217872722 0.161548253980588 no 571 0.157855130915964 748 2995952 SGTC_400 oxethazaine 37.5 µM 1.00240798274263 0.161766936858785 no 572 0.158073294121127 770 4621 A local anesthetic. SGTC_2894 9048625 32.47 µM 0.996784229304989 0.163131389693873 no 573 0.159434627425808 800 4092861 SGTC_2172 5754775 163.918 µM 0.996598153598939 0.163176663437258 no 574 0.159479801277357 722 2263357 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.993288953904375 0.163983182479896 no 575 0.160284579532187 820 688798 SGTC_2180 6301957 200 µM 0.99314666655768 0.1640179186867 no 576 0.160319242407507 841 845462 SGTC_913 3487-1245 167 µM 0.99233405658028 0.164216390330639 no 577 0.160517297654204 768 4016153 SGTC_1726 st035556 14.5795 µM 0.992016434457712 0.164294008590757 no 578 0.160594754270525 859 5919439 SGTC_2231 micatex 6.853 µM 0.991888680633971 0.164325234878686 no 579 0.16062591571849 807 20737 An antifungal of unknown mechanism. SGTC_22 0964-0034 14.468 µM 0.99061740291514 0.164636177176286 no 580 0.160936218309279 840 138402 SGTC_2223 6903751 107.57 µM 0.989732442987204 0.164852854779494 no 581 0.161152456523141 755 5598863 SGTC_1570 verbenone 133 µM 0.98545550501826 0.165902641645283 no 582 0.162200188540941 842 29025 A natural terpanoid with antifungal properties. SGTC_2426 5582046 32.21 µM 0.984164651001933 0.16622033249035 no 583 0.162517281610719 834 2251934 SGTC_231 b-estradiol 524 µM 0.982907003346412 0.166530228604096 no 584 0.162826605346774 748 450 A steroid. SGTC_3120 9124077 49.47 µM 0.980905909193554 0.167024085161634 no 585 0.163319571591587 849 18774327 YGL155W CDC43 SGTC_3070 9117005 49.47 µM 0.980425787326393 0.167142716346834 no 586 0.163437992899892 775 8779016 SGTC_1902 st060212 70.5 µM 0.978710163070081 0.167567066091313 no 587 0.16386160451953 841 688944 SGTC_2385 9074692 200 µM 0.977722157749557 0.16781175813077 no 588 0.16410587988102 825 17046906 SGTC_766 1391-0721 126 µM 0.970742966633122 0.169546791163208 no 589 0.165838144957841 847 1020919 YIL115C NUP159 SGTC_2666 tannic acid 100 µM 0.97047679826157 0.169613187898119 no 590 0.165904442231759 864 16134267 A thiamine antagonist. SGTC_2476 5806916 10.51 µM 0.965443769980598 0.170871835261638 no 591 0.167161293615008 822 2870194 SGTC_847 0342-0274 5.54 µM 0.960799023161071 0.172038670685582 no 592 0.168326614928087 885 18097 SGTC_1362 1611-0397 101 µM 0.9573861184077 0.172899281439735 no 593 0.169186201196062 837 27816 SGTC_423 5-fluorouracil 457 µM 0.957270446925941 0.172928497574692 no 594 0.169215383919346 811 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2391 6285546 200 µM 0.956346880861805 0.173161883368675 no 595 0.169448506028034 857 846083 SGTC_656 4090-1979 187 µM 0.955476831517149 0.173381928865772 no 596 0.169668308140705 907 22330961 SGTC_863 0466-0191 129 µM 0.952122952659624 0.174231828151065 no 597 0.170517314885212 895 765160 YPR165W RHO1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.95163062256193 0.174356810944161 no 598 0.170642172771176 839 7104 SGTC_3128 9127691 49.47 µM 0.950805949854623 0.174566289724229 no 599 0.170851445838059 743 41316314 SGTC_2443 5493264 126.67 µM 0.949415747776176 0.17491978277635 no 600 0.171204602069914 877 5340055 SGTC_1781 st038725 66.3 µM 0.948086396284731 0.175258227614603 no 601 0.171542736542072 904 4270275 YIL048W NEO1 SGTC_1286 0929-0070 131 µM 0.947718698130375 0.175351914605124 no 602 0.17163633970881 882 1420408 SGTC_1115 galangin 695.678 nM 0.947483690120727 0.175411809678014 no 603 0.171696181666718 935 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2233 sulbentine 40.3845 µM 0.947248182856229 0.175471845002115 no 604 0.171756164122622 901 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_298 1391-0729 10 µM 0.947133338075626 0.175501125865642 no 605 0.171785419335654 843 3237558 SGTC_3040 9091894 49.47 µM 0.946170458281791 0.175746743837004 no 606 0.172030825618385 785 25236966 SGTC_2274 7947094 46.08 µM 0.945270242152724 0.175976573999527 no 607 0.17226046331865 924 2971028 SGTC_3355 9151058 44.0485 µM 0.945217947418712 0.175989930981002 no 608 0.172273809281693 846 17015728 SGTC_2062 5245942 200 µM 0.945034770210675 0.176036722677112 no 609 0.172320562522892 941 1376160 SGTC_1322 1348-1070 12 µM 0.944275450874692 0.176230770968317 no 610 0.172514453736408 842 6758089 SGTC_2462 5162487 171.77 µM 0.942388540260078 0.176713567408599 no 611 0.172996876097766 885 2259986 SGTC_1089 terbinafine 2.25 µM 0.941976055607401 0.176819219521394 no 612 0.173102449527176 864 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2922 7999257 32.47 µM 0.941600679123514 0.17691540159469 no 613 0.1731985609604 799 2988377 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.937199301521035 0.178045624721939 no 614 0.174328024509188 858 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1024 4507-0395 26 µM 0.936138344360539 0.178318745770401 no 615 0.174600981429143 821 4201836 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.934069534283535 0.178852076131041 no 616 0.175134012989281 817 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_596 1155-0152 116 µM 0.92887537812293 0.18019552648894 no 617 0.176476837216182 906 280313 SGTC_2357 9067248 200 µM 0.926602149662782 0.180785476510834 no 618 0.177066569194113 838 9150235 SGTC_971 1315-0384 26.7 µM 0.923498575487196 0.181592871001928 no 619 0.177873721198937 852 6769120 SGTC_1807 st050092 58.9 µM 0.923234756220782 0.181661607465579 no 620 0.177942439993645 841 5008496 SGTC_1950 st077106 7.18 µM 0.923041287179091 0.181712024962878 no 621 0.177992844827052 888 13831864 SGTC_777 1315-0167 517 µM 0.922611888362049 0.181823956381843 no 622 0.178104749026214 830 4221767 SGTC_1207 2099-0101 141 µM 0.922028909428166 0.181975990547993 no 623 0.178256748195754 949 5837381 SGTC_2175 5807670 165.306 µM 0.920648761677486 0.182336233870271 no 624 0.178616917664782 875 241186 SGTC_969 1313-0238 134 µM 0.920343423528168 0.182415992760836 no 625 0.17869666192658 909 5212874 SGTC_947 3447-0010 211 µM 0.919300522979919 0.182688578304966 no 626 0.178969202181428 868 748350 SGTC_2741 miltefosine 3.04 µM 0.918027784907757 0.183021581436232 no 627 0.179302159850975 788 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1038 k292-0204 154 µM 0.917769865260897 0.183089110453665 no 628 0.179369680970443 824 4454212 SGTC_1868 st057644 42.7 µM 0.916765395001023 0.183352250903649 no 629 0.179632794887843 961 688665 SGTC_2804 7954240 19.48 µM 0.916001241065458 0.183552593680533 no 630 0.179833121986792 903 828705 SGTC_2080 5212524 12.4 µM 0.915587748491617 0.183661058348491 no 631 0.179941579796023 874 260183 SGTC_2289 7946404 165.07 µM 0.914170340352904 0.184033166575797 no 632 0.180313673177613 927 1246120 YPR165W RHO1 SGTC_1381 2324-0066 62.1 µM 0.913753259075052 0.184142751085493 no 633 0.180423255875236 840 10885928 SGTC_2977 9011197 71.43 µM 0.912472781792614 0.184479439144411 no 634 0.180759945639559 820 2704722 SGTC_1503 4585-0012 61.3 µM 0.911927604174228 0.184622904020865 no 635 0.180903414572352 891 2922052 SGTC_2073 5212005 126 µM 0.910797762607037 0.184920445497529 no 636 0.18120097079276 807 691789 SGTC_1957 st077035 62.4 µM 0.90708742186905 0.185899650579279 no 637 0.182180284515667 930 705593 SGTC_606 k015-0008 38.6 µM 0.906945032850659 0.185937292767271 no 638 0.182217932714986 978 1970475 SGTC_626 0214-0009 33 µM 0.906547308073848 0.186042460959167 no 639 0.182323118420017 935 3437874 SGTC_380 3970-0968 6 µM 0.905937072056902 0.186203894017689 no 640 0.182484580417594 867 2891601 SGTC_117 lucigenin 22.078 µM 0.904820470507749 0.186499506692129 no 641 0.182780252531763 933 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1143 3454-2408 5.08 µM 0.900841692228306 0.187555222340819 no 642 0.183836248293007 892 X1143 SGTC_789 1309-1135 70.6 µM 0.89841584182174 0.188200697739828 no 643 0.184481946928127 909 3092424 SGTC_898 1000-0849 28.3 µM 0.898294231577635 0.18823309209096 no 644 0.184514353517926 947 6751807 SGTC_1934 st074720 32.6 µM 0.898154742960062 0.188270253091994 no 645 0.184551528680121 965 17250992 SGTC_2241 6772625 37.8075 µM 0.897136481095168 0.18854166415966 no 646 0.18482304711433 887 2285411 SGTC_1779 st039427 55 µM 0.896331995125991 0.188756265164919 no 647 0.185037737911537 1008 1124498 SGTC_2400 5203494 178.7 µM 0.894770127983449 0.189173331358259 no 648 0.185454990958722 842 6777674 SGTC_3166 9102297 49.47 µM 0.894290984205777 0.189301391025905 no 649 0.185583111265797 901 25237072 SGTC_1861 st057647 17.4 µM 0.892931283129541 0.189665085740106 no 650 0.185946986548815 934 688668 SGTC_1661 st013063 9.66 µM 0.892195217033914 0.189862148905736 no 651 0.186144152704485 981 721395 SGTC_1378 2093-0007 380 nM 0.889492715082263 0.190586754782092 no 652 0.18686916831744 896 3618014 SGTC_496 calpeptin 138 µM 0.885646096267369 0.191621049237991 no 653 0.1879041318 843 73364 A calpain inhibitor. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.884370194908854 0.191964876659851 no 654 0.188248203442541 876 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3091 9116372 49.47 µM 0.883888820006925 0.19209469467597 no 655 0.18837811648989 888 17169793 SGTC_2628 lathosterol 100 µM 0.883837402019377 0.192108564342385 no 656 0.188391996400721 950 6710616 SGTC_3061 glucosamine 200 µM 0.88322157443058 0.192274727425354 no 657 0.188558283585287 919 91431 and experimental redox chemotherapeutic SGTC_1370 2001-0092 44.6 µM 0.880718900775887 0.192950904844435 no 658 0.189234992055489 1032 790957 SGTC_808 0711-0032 135 µM 0.878962621119684 0.19342628607344 no 659 0.189710771585404 951 4252555 SGTC_2549 cedrol 20.94 µM 0.877778114694273 0.193747305615869 no 660 0.190032071708741 913 6708665 A sedative which affects the nervous system. SGTC_2866 9034245 58.44 µM 0.876827140742056 0.194005269171717 no 661 0.19029026750055 951 6462273 SGTC_516 3992-2719 87.3 µM 0.874746373285471 0.194570432772217 no 662 0.19085596092415 961 5350887 YDR037W KRS1 SGTC_1402 3909-7673 35.9 µM 0.874546744512897 0.194624707175778 no 663 0.190910287724696 922 5328014 SGTC_1484 3473-2379 286 µM 0.872420818434765 0.195203268108374 no 664 0.191489423674937 1129 671917 SGTC_1238 0333-0287 48.8 µM 0.872048987238177 0.195304567529683 no 665 0.191590826868081 932 7226 SGTC_293 4049-0273 38.5 µM 0.870316154486595 0.195777071013754 no 666 0.192063826531913 891 1380311 SGTC_1840 st055363 71 µM 0.870211504619006 0.195805628814734 no 667 0.192092414961721 875 676033 SGTC_2152 5568786 200 µM 0.870020051646803 0.195857880773749 no 668 0.192144723150668 928 5399883 SGTC_2865 9030313 51.95 µM 0.869548985214641 0.195986481752227 no 669 0.192273463559118 858 42562754 SGTC_110 0850-0284 111.64 µM 0.867569994093085 0.196527305082255 no 670 0.19281488939278 821 3906265 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.866579999398891 0.196798192152339 no 671 0.19308608802575 1013 688761 SGTC_1166 k206-0078 225 µM 0.86439589769803 0.197396615608685 no 672 0.193685222831714 968 5404595 SGTC_275 trichlorophene 5.69 µM 0.864227242934494 0.197442871162222 no 673 0.193731534689102 1041 62616 SGTC_2610 ononetin 44.17 µM 0.863528434724636 0.197634597366608 no 674 0.193923496284514 930 259632 SGTC_1389 3405-0187 19 µM 0.863237966053195 0.197714323940839 no 675 0.194003321697916 878 799890 SGTC_2380 9035439 200 µM 0.863183151208616 0.197729371460065 no 676 0.194018387934859 1016 6462575 SGTC_1128 3448-9350 235 µM 0.862915007398981 0.197802991039136 no 677 0.194092099377664 850 619386 SGTC_3180 9109287 49.47 µM 0.861942930790484 0.198070016011243 no 678 0.194359461555367 898 18891271 SGTC_2508 celastrol 40.54 µM 0.861893228285383 0.198083674907466 no 679 0.194373137869144 907 122724 Celastrol is a natural product and antioxidant. SGTC_373 0844-0104 25.9 µM 0.861628891871826 0.198156327554866 no 680 0.194445883437593 1004 5375804 SGTC_792 4534-1957 155 µM 0.85966739535546 0.198695945717294 no 681 0.194986206271407 957 1717904 SGTC_1510 1123-0200 71.5 µM 0.858783246886763 0.198939469126812 no 682 0.195230056051805 1019 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_370 0180-0345 38.7 µM 0.858471519959521 0.199025371791113 no 683 0.19531607508133 889 3989527 SGTC_865 0488-0499 301 µM 0.854982761547682 0.199988293814138 no 684 0.19628034555636 1025 9634651 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.854419018716698 0.200144153293337 no 685 0.196436430884272 992 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2711 st079103 59.1 µM 0.853913850725221 0.200283880435236 no 686 0.19657636229024 960 54693780 SGTC_3329 9141233 27.5565 µM 0.85008049763058 0.20134607688246 no 687 0.197640166763583 978 4909101 YNL103W MET4 SGTC_1728 st035614 33.7865 µM 0.849493875463757 0.201508923344114 no 688 0.1978032683565 996 15945546 SGTC_260 nsc-65238 3.989 µM 0.846205343103687 0.202423281071564 no 689 0.198719100879856 950 3246252 SGTC_1152 3909-8331 15.9 µM 0.846035823898771 0.202470482064951 no 690 0.198766379948269 940 16001939 SGTC_2019 4016004 108 µM 0.845131462864763 0.202722403880044 no 691 0.199018721683913 941 45595336 SGTC_1021 4476-0760 85.3 µM 0.843143807007962 0.203276749705405 no 692 0.199574010577938 957 746768 SGTC_302 1094-0063 18.9 µM 0.842329578584915 0.203504094293433 no 693 0.199801749486916 918 5440289 SGTC_827 3253-0474 693 µM 0.841234409733702 0.203810120664074 no 694 0.200108313572465 1022 5402065 SGTC_611 3453-1652 23.7 µM 0.839216743014115 0.204374641123495 no 695 0.200673846737311 1025 1560575 SGTC_2911 7942208 15.64 µM 0.837298203484546 0.204912289310793 no 696 0.201212484418535 943 1243384 SGTC_113 0099-0221 2.5 µM 0.837000336811126 0.204995838302912 no 697 0.201296189358629 946 89219 SGTC_2003 4023581 200 µM 0.835130983948055 0.205520637564288 no 698 0.20182198157888 966 16641307 SGTC_1091 telmisartan 47.6 µM 0.835008174467472 0.205555142811418 no 699 0.201856552921183 1028 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2730 imipramine 71.33 µM 0.834739658366242 0.205630598595706 no 700 0.201932153589038 1067 3696 A tricyclic antidepressant. SGTC_2141 5621638 7.665 µM 0.833737902079113 0.205912247460818 no 701 0.202214347456643 991 2856238 SGTC_2661 dactinomycin 12.96 µM 0.833348858479288 0.206021690708104 no 702 0.202324004268943 1019 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1224 0823-0416 294 µM 0.833311235813262 0.206032276303979 no 703 0.202334610574325 1009 3598164 SGTC_463 ikarugamyin 104 µM 0.833024262602701 0.206113030329161 no 704 0.202415522893173 1011 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3345 9148410 3.559 µM 0.832619481114977 0.206226967405809 no 705 0.202529684233582 976 4903596 SGTC_2329 6138490 200 µM 0.832013255241301 0.206397676452643 no 706 0.2027007313134 859 720019 SGTC_2642 cholecalciferol 100 µM 0.831076083078396 0.206661742413673 no 707 0.202965324946991 993 9821465 A vitamin D precursor, similar to steriods. SGTC_188 3229-0966 278.469 µM 0.830588819877689 0.206799117040672 no 708 0.203102976375973 1113 5722370 SGTC_2600 tangeritin 87.95 µM 0.830470562157927 0.206832465714379 no 709 0.203136392481709 948 68077 A bioactive flavone. SGTC_911 3456-4043 236 µM 0.830285670619964 0.206884611501844 no 710 0.203188643894531 1021 914281 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.830031965261029 0.206956177821927 no 711 0.203260355545032 1037 23847180 SGTC_2616 abietic acid 100 µM 0.826704417594707 0.207896182487581 no 712 0.204202308438946 1040 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_990 3985-0011 41.3 µM 0.826605795047391 0.207924080954408 no 713 0.204230265842337 931 5399565 YGL099W LSG1 SGTC_727 3032-0951 202 µM 0.825252504946222 0.208307124542357 no 714 0.204614125104491 963 3652836 SGTC_2783 7738165 71.43 µM 0.824782476664928 0.208440261589727 no 715 0.204747548487047 914 17201110 SGTC_1001 4048-4355 44.4 µM 0.822009675505467 0.209226687219211 no 716 0.205535695117416 973 21824233 SGTC_736 0958-0254 92.6 µM 0.820551831235107 0.209640862608303 no 717 0.205950797210105 1044 6812352 SGTC_1365 1672-3266 55.4 µM 0.819890914577078 0.209828788596434 no 718 0.206139148288156 1034 6415873 SGTC_393 acivicin 6.25 µM 0.818035779348536 0.210356809205045 no 719 0.20666837865313 935 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1925 st057770 10.1 µM 0.81738584529205 0.210541982017868 no 720 0.206853981077175 947 5989122 SGTC_97 0535-0701 19.132 µM 0.816132929864467 0.210899220178949 no 721 0.207212055895069 964 2832013 YGL099W LSG1 SGTC_2460 5552655 174.22 µM 0.816122387408811 0.210902227609213 no 722 0.207215070412585 1011 5401989 SGTC_1881 5652484 16 µM 0.815763677860262 0.211004571119084 no 723 0.207317655538723 988 2255129 SGTC_228 caffeine 993.056 µM 0.814752625756805 0.211293191274935 no 724 0.207606961633682 982 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3259 9138485 49.47 µM 0.812647371194432 0.211894909737263 no 725 0.208210131724747 1104 17646153 SGTC_1027 k015-0025 8.67 µM 0.81240480413249 0.211964303978758 no 726 0.208279695249521 1041 3598955 SGTC_1895 st058434 18.3 µM 0.811367368107163 0.212261246444818 no 727 0.208577366452291 1060 5393175 SGTC_2836 9010338 19.48 µM 0.810965273359212 0.212376402270823 no 728 0.208692806787339 991 2994051 SGTC_1177 0983-0204 23.6 µM 0.810896275220173 0.212396166301565 no 729 0.208712619754692 1057 766818 SGTC_3218 9131285 49.47 µM 0.810660149961738 0.21246381084951 no 730 0.208780432030067 1057 17156417 SGTC_2364 9055074 200 µM 0.810354164414585 0.212551487510493 no 731 0.208868326633538 1012 6470630 SGTC_3255 9139072 49.47 µM 0.808447495987808 0.213098297481929 no 732 0.209416509693084 1070 17646060 SGTC_2539 epi(13)torulosol 80 µM 0.807969516627922 0.213235504844945 no 733 0.209554065337246 1017 6708597 SGTC_882 0843-0131 351 µM 0.807040790303073 0.213502249566757 no 734 0.20982149143876 1078 5425421 SGTC_2916 7875993 68.79 µM 0.806371510903404 0.213694597580256 no 735 0.210014334299513 1009 1299250 SGTC_1287 0971-0001 34.6 µM 0.805598229058153 0.213916961090053 no 736 0.210237273534862 1042 4665869 SGTC_508 roscovitine 141 µM 0.80457579644602 0.214211176651516 no 737 0.210532256875745 1058 160355 A CDKinase inhibitor. SGTC_483 fpl-64176 144 µM 0.802883938307756 0.214698543087262 no 738 0.211020910189755 1020 3423 SGTC_2638 epoxomicin 18 µM 0.802807514447349 0.2147205733867 no 739 0.211042999102413 1043 9915668 A protesome inhibitor. SGTC_2718 lomofungin 53.02 µM 0.802119714012785 0.214918901057389 no 740 0.211241856160094 1019 5351222 A RNA synthesis inhibitor. SGTC_482 fipronil 114 µM 0.800828274530085 0.215291575715419 no 741 0.211615533954376 1039 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_290 2043-6722 48.1 µM 0.800595162548696 0.21535888548808 no 742 0.211683026069819 1034 773758 YLR208W SEC13 SGTC_3234 9132280 49.47 µM 0.800133812732241 0.215492133639196 no 743 0.211816636240125 1048 17612295 SGTC_612 0302-0167 22.4 µM 0.799536040261184 0.215664854806457 no 744 0.21198982874226 1089 235821 SGTC_313 3474-0040 5.03 µM 0.799285039750898 0.215737403145718 no 745 0.212062575754203 1036 1043375 YIL048W NEO1 SGTC_21 0849-0113 22.993 µM 0.797904388771815 0.216136714685924 no 746 0.212462988175867 1044 1560156 SGTC_2779 methotrexate 400 µM 0.797339676322773 0.216300163942934 no 747 0.212626891648069 1149 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2110 5483698 200 µM 0.796387924234385 0.216575799052469 no 748 0.21290329745047 1044 2848765 YHR062C RPP1 SGTC_2833 9001315 45.46 µM 0.796095225549666 0.216660607798923 no 749 0.212988344518331 1009 2989378 SGTC_169 k015-0017 16.025 µM 0.795645158641553 0.216791051082315 no 750 0.213119155453635 1016 1840002 SGTC_2972 9093619 59.92 µM 0.795091871686177 0.216951472931534 no 751 0.213280031263212 995 25236256 SGTC_2369 9071472 200 µM 0.794670490429373 0.21707369561988 no 752 0.213402601158378 1036 17296037 SGTC_1355 1499-0035 1.68 µM 0.794562831434065 0.217104928760888 no 753 0.213433923211709 1024 1548538 SGTC_697 0508-1955 564 µM 0.793532810941715 0.217403881052133 no 754 0.213733730368062 1069 6243113 SGTC_1022 4477-0945 21.3 µM 0.79326323687751 0.217482161228354 no 755 0.213812235533697 1033 4648966 SGTC_1786 berberine 21.6 µM 0.791494034565723 0.217996314100566 no 756 0.214327877942871 1002 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1230 0170-0365 3.77 µM 0.789683784899562 0.218523120503428 no 757 0.214856231700756 1156 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_855 0428-0020 25 µM 0.78941774760422 0.218600602580217 no 758 0.214933943163056 972 6812414 SGTC_3346 9158254 43.5805 µM 0.788224325943034 0.218948375425842 no 759 0.215282751270677 1017 17639500 SGTC_2880 9042983 58.44 µM 0.787762989658274 0.219082897841478 no 760 0.215417676626563 1061 6464714 SGTC_3178 9107506 49.47 µM 0.784824510923523 0.219940852256386 no 761 0.216278233483556 1036 8897194 SGTC_2740 felodipine 17.08 µM 0.783374460110869 0.220364936378957 no 762 0.216703624723256 1013 3333 L-type calcium channel blocker SGTC_2318 6029776 164 µM 0.782490865951235 0.220623583377188 no 763 0.216963075639831 1043 818325 SGTC_2125 5246583 200 µM 0.78089974435361 0.221089777142345 no 764 0.217430731229067 1119 835267 SGTC_335 4077-0256 27.6 µM 0.77862276027085 0.22175790605896 no 765 0.218100983826488 1127 3121989 SGTC_1149 3909-7961 23.3 µM 0.778071603696731 0.221919803575075 no 766 0.218263401009085 1048 735261 SGTC_2670 beta-carotene 100 µM 0.776470333708003 0.222390545616004 no 767 0.218735665259474 1026 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1804 st050076 49.1 µM 0.775151784165471 0.222778600614092 no 768 0.219124987591827 1046 3895976 SGTC_1188 1403-0014 4.57 µM 0.774784644845782 0.222886719988089 no 769 0.219233462077638 1099 9614867 SGTC_1684 st024538 14.6195 µM 0.774459947524964 0.22298236546305 no 770 0.219329422423479 1064 6732859 SGTC_455 paf C-16 10 µM 0.774037693521019 0.223106782986117 no 771 0.219454250560051 1049 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3193 9111931 49.47 µM 0.768432664083226 0.224762050299706 no 772 0.221115090387271 1111 17087244 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.767692603928116 0.224981122795508 no 773 0.22133491561828 1148 91467 include heat shock SGTC_2263 7948595 193.29 µM 0.767013078721637 0.225182382274767 no 774 0.22153686974898 999 2971371 SGTC_2944 9067346 25.62 µM 0.766232991376315 0.225413551600024 no 775 0.221768840644164 1008 6473075 SGTC_1135 dihydrocapsaicin 536.708 nM 0.766192450961453 0.225425568926615 no 776 0.221780899747932 1037 107982 A Capsaicinoid. SGTC_1825 st052143 62.6 µM 0.766137807858369 0.225441767263108 no 777 0.221797154413331 1066 674173 SGTC_358 0075-0058 9.45 µM 0.764020487444233 0.226069930420074 no 778 0.222427516850374 1110 1069125 SGTC_190 3970-0790 3.722 µM 0.761911984140262 0.226696459666396 no 779 0.223056268466047 1074 2832352 SGTC_1036 k216-0215 33.5 µM 0.758721790612997 0.227646266974223 no 780 0.224009499463501 1092 622330 SGTC_111 0083-0039 52.457 µM 0.757149836201885 0.228115103229153 no 781 0.224480049850792 1022 759313 SGTC_2163 5671233 125 µM 0.75529051426769 0.228670347250321 no 782 0.225037344491023 1146 701023 SGTC_3130 9127414 49.47 µM 0.754877965242983 0.228793648387019 no 783 0.225161104020662 1139 1494646 SGTC_2288 7946289 167.31 µM 0.75346503122848 0.229216223593188 no 784 0.225585258526442 1142 1246052 SGTC_3083 9117465 49.47 µM 0.752894456278843 0.229386993065036 no 785 0.225756669861084 1126 16420915 SGTC_401 neomycin 50 µM 0.751731653839909 0.229735233131321 no 786 0.226106225324289 1075 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2703 st077852 53.4 µM 0.751676862190049 0.22975164962359 no 787 0.226122704040613 1077 6281836 SGTC_3327 9140648 26.9345 µM 0.75034786397468 0.230150040812073 no 788 0.226522611178884 1101 8029710 SGTC_3307 9126885 69.2785 µM 0.749676881365186 0.230351326673662 no 789 0.226724667282265 1104 24824909 SGTC_2150 5556613 200 µM 0.749435030253594 0.230423902918163 no 790 0.226797521956697 1105 743190 SGTC_2745 rifampicin 24.3 µM 0.748530910045877 0.230695330339787 no 791 0.227069994004438 1017 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1955 wogonin 32.4 µM 0.747062939261918 0.231136412475612 no 792 0.22751278488868 1104 5281703 A flavanone. SGTC_2005 4024620 188 µM 0.746521896519339 0.231299098549727 no 793 0.227676104695894 1120 236743 SGTC_517 1365-0151 113 µM 0.743615935584296 0.232173983510593 no 794 0.22855442985576 1120 768657 SGTC_2007 4011539 71.82 µM 0.738638790039356 0.233676700492646 no 795 0.230063181616683 1115 45595301 SGTC_2698 st077697 67.5 µM 0.738623246542759 0.23368140186952 no 796 0.230067902122234 1077 3154499 SGTC_879 0831-1030 162 µM 0.737534485375927 0.234010845387025 no 797 0.230398689902592 1144 1549252 SGTC_837 0091-0265 12.5 µM 0.736612753531203 0.234289949198583 no 798 0.230678938492607 1106 759367 SGTC_652 0437-0092 114 µM 0.736271904231811 0.234393206274771 no 799 0.230782620464871 1115 3091274 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.735558960514691 0.23460926724251 no 800 0.230999572908222 1120 688667 SGTC_1154 4088-0362 150 µM 0.735519661054392 0.234621180332282 no 801 0.231011535246216 1175 6618304 SGTC_1428 4049-0204 61.7 µM 0.734902607781476 0.234808275386198 no 802 0.23119940503602 1175 X1428 SGTC_710 3448-4187 58 µM 0.734428592669705 0.234952056218669 no 803 0.231343782896361 1160 3946412 SGTC_1731 st035964 63 µM 0.734389595182822 0.234963887313153 no 804 0.231355663181477 1081 6739575 SGTC_2592 piperlongumine 83.33 µM 0.733447612605084 0.235249766866484 no 805 0.231642734295926 1098 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1953 st076800 12.1 µM 0.732439468354217 0.235555938270465 no 806 0.231950188109081 1074 297591 SGTC_399 oxolinic acid 75 µM 0.732194828758881 0.235630267961001 no 807 0.232024830109021 1105 4628 A DNA gyrase inhibitor. SGTC_2008 4012253 172 µM 0.730693602581222 0.236086673843584 no 808 0.232483162015249 1157 603940 SGTC_1962 st076595 64.5 µM 0.728332870493224 0.236805372593943 no 809 0.233204922708181 1167 279619 SGTC_1680 diphenhydramine 100 µM 0.728064880966653 0.236887035010303 no 810 0.233286935281106 1106 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2998 9066762 71.4286 µM 0.727454202387592 0.237073180287789 no 811 0.233473880429141 1157 4945196 SGTC_316 k060-0003 58.6 µM 0.726580798094731 0.237339548487071 no 812 0.233741397340704 1172 6152314 SGTC_2606 farnesol 9.78 µM 0.721391975827417 0.238925403194525 no 813 0.235334191069768 1155 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_750 4073-0104 132 µM 0.720491628419825 0.239201164247693 no 814 0.235611176140048 1007 22330957 SGTC_2098 5376439 882.5 nM 0.719995378707587 0.239353231384937 no 815 0.235763920452312 1198 2844116 SGTC_1606 st000094 49.2 µM 0.719291517087105 0.239569008131418 no 816 0.235980660757335 1191 1242210 SGTC_2531 methyl deoxycholate 70.07 µM 0.716546565752887 0.240411517713924 no 817 0.236826962583542 1146 16667744 Haematoxylin. SGTC_2834 9001755 58.44 µM 0.716335768144634 0.240476284611184 no 818 0.236892022976672 1066 2989575 SGTC_3022 9087993 49.47 µM 0.713429087660524 0.241370321100245 no 819 0.237790139513597 1174 17173644 SGTC_2017 5132927 60.65 µM 0.71284360828002 0.241550621038529 no 820 0.237971268733723 1172 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2423 st077119 87.2 µM 0.711944509378948 0.241827643278301 no 821 0.238249569338994 1160 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1891 st059073 26.2 µM 0.711230385941776 0.242047795329177 no 822 0.238470740953647 1218 688754 SGTC_1187 1391-0724 117 µM 0.710754938755017 0.242194427819032 no 823 0.238618054308865 1198 6997986 SGTC_3162 9099653 49.47 µM 0.710588053356912 0.242245908297791 no 824 0.238669774167287 1146 25237511 SGTC_456 gingerol 170 µM 0.710481738356176 0.242278707232193 no 825 0.238702725705392 1237 442793 A herb. SGTC_2390 9097792 176.6 µM 0.710476258031747 0.242280398016512 no 826 0.23870442435836 1145 4497149 SGTC_1240 0356-0016 42.1 µM 0.708726527014797 0.24282055013211 no 827 0.239247099939994 1143 4305613 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.708657000726579 0.242842026754795 no 828 0.239268677295043 1184 5282362 SGTC_1716 st033144 30.6155 µM 0.705008526058662 0.243970479052918 no 829 0.240402465129093 1196 674617 SGTC_1481 3346-2004 36 µM 0.704582773147722 0.244102346064479 no 830 0.240534961090613 1195 2770522 SGTC_1749 st037932 54.2 µM 0.704381184173086 0.244164796943315 no 831 0.240597710231208 1151 594497 SGTC_883 0850-0245 24.6 µM 0.703554337473589 0.244421038480829 no 832 0.240855178235373 1191 6823229 YPR165W RHO1 SGTC_1734 st037168 69.4 µM 0.701426923302825 0.245080994119843 no 833 0.241518312410358 1134 708907 SGTC_2387 9077560 195.08 µM 0.699028369490892 0.245826209284173 no 834 0.24226715082285 1181 5303272 SGTC_3057 9095946 49.47 µM 0.698611364016692 0.245955894192961 no 835 0.242397469942542 1219 24540043 SGTC_1070 indatraline 8.81 µM 0.698076512658966 0.246122281823128 no 836 0.242564672869269 1185 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_904 1141-0088 396 µM 0.697850848714262 0.246192502029158 no 837 0.242635237690554 1161 1378119 SGTC_2205 7238770 200 µM 0.697052786685837 0.246440922405841 no 838 0.242884879782141 1210 279867 SGTC_842 0271-0008 11.1 µM 0.696893025949788 0.246490668785268 no 839 0.242934871289916 1218 1221709 SGTC_311 1315-0136 58 µM 0.694125717299142 0.247353207879832 no 840 0.243801685947622 1220 6759207 SGTC_1064 honokiol 6.76 µM 0.693845667721365 0.247440586003816 no 841 0.243889499868954 1197 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_55 0767-0285 6.563 µM 0.69085314125132 0.248375311636769 no 842 0.244828918030397 1175 3116166 SGTC_2292 7671323 168.05 µM 0.690458776229 0.24849863307609 no 843 0.244952862739239 1194 937504 SGTC_1056 3448-1962 115 µM 0.689989378055251 0.248645460565267 no 844 0.245100433562237 1181 715507 SGTC_2146 5545642 200 µM 0.689523910185753 0.24879110427436 no 845 0.245246815968529 1230 825326 SGTC_2937 9044753 11.33 µM 0.689121622759801 0.248917015565914 no 846 0.245373366963361 1222 6465530 YGL099W LSG1 SGTC_615 k087-0205 167 µM 0.689032645197471 0.248944869088948 no 847 0.245401362134826 1183 9642773 SGTC_430 0958-0115 16.4 µM 0.687075088588841 0.249558081771563 no 848 0.246017705776058 1164 6833180 SGTC_1277 0873-0036 22 µM 0.685718743173307 0.249983432750513 no 849 0.246445242517883 1237 5965735 SGTC_1419 3993-2473 62.6 µM 0.685615178996528 0.250015926358561 no 850 0.246477903571979 1240 704026 SGTC_1107 amlodipine 47 µM 0.684170558669788 0.250469414397803 no 851 0.246933735478771 1121 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2671 danthron 100 µM 0.684011242929818 0.250519452677015 no 852 0.246984033176491 1185 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2248 tofa 1.1 µM 0.683807926650513 0.250583318446123 no 853 0.247048230280354 1161 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2235 salicylic acid 500 µM 0.683180653808023 0.25078041191838 no 854 0.247246347888945 1224 338 A COX inhibitor and kinase inhibitor. SGTC_2993 9054257 71.4286 µM 0.682865712373945 0.250879399640791 no 855 0.247345850892306 1222 6470217 YGL055W OLE1 SGTC_1401 3807-4679 7.6 µM 0.682539229680084 0.250982036669645 no 856 0.247449022848596 1197 3291456 SGTC_3270 9137563 49.47 µM 0.682258781887359 0.251070219351048 no 857 0.247537665651964 1177 17015724 SGTC_479 n-linoleoylglycine 10 µM 0.682125954571562 0.251111990665314 no 858 0.24757965509204 1213 6433346 An anti-infammatory. SGTC_2607 solasodine 47.35 µM 0.67962828431723 0.251898137877813 no 859 0.248369927874076 1237 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1176 0848-0131 83.3 µM 0.679214729043179 0.252028430549873 no 860 0.248500908032623 1278 6769040 SGTC_1229 0139-0193 12.2 µM 0.67713029823227 0.252685681874767 no 861 0.249161643457303 1255 3090752 SGTC_2912 7964298 10.93 µM 0.67670435993397 0.252820097397647 no 862 0.249296774828278 1252 2975850 SGTC_768 0384-0033 77.3 µM 0.676171411023738 0.252988335806178 no 863 0.249465910793646 1220 3965305 YMR134W ERG29 SGTC_791 1348-1292 225 µM 0.67589054952212 0.253077020331996 no 864 0.24955506916064 1233 5437054 SGTC_3051 9093778 49.47 µM 0.675724040823715 0.25312960466047 no 865 0.249607934677271 1239 17217378 SGTC_211 3455-0679 143.504 µM 0.675126861038607 0.253318244454273 no 866 0.249797584608303 1246 748649 SGTC_1557 sumaresinolic acid 42.3 µM 0.674940854263014 0.253377016188814 no 867 0.249856671506581 1181 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1568 digitonin 820 nM 0.674490759476595 0.253519260287544 no 868 0.249999679274407 1242 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_936 3005-4620 401 µM 0.672006823608428 0.254305016144587 no 869 0.250789676144334 1253 777207 SGTC_1316 1272-0050 65.9 µM 0.670726233022149 0.254710609973597 no 870 0.251197473986868 1234 7340392 SGTC_2652 actinonin 100 µM 0.67016423570671 0.254888714922171 no 871 0.251376549956381 1225 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_73 0327-0325 16.231 µM 0.663977479808825 0.256853685822996 no 872 0.253352362402202 1272 53298 SGTC_899 1083-0020 478 µM 0.662691310128763 0.257263172769215 no 873 0.253764138194832 1288 767123 SGTC_2352 9027995 87.8 µM 0.661696956420012 0.257579984627032 no 874 0.254082727839955 1223 2997347 SGTC_3042 9091578 49.47 µM 0.66154726237775 0.257627696310725 no 875 0.254130707782083 1217 25236497 SGTC_1769 st044406 64.4 µM 0.661180265065407 0.257744688046279 no 876 0.254248357883167 1251 670903 SGTC_3044 9093193 49.47 µM 0.6609669265818 0.257812708954034 no 877 0.254316761954515 1215 25236277 SGTC_1506 4226-2149 212 µM 0.660750428560345 0.257881746772924 no 878 0.254386188950183 1275 991114 SGTC_1751 st044839 27.194 µM 0.660730647494786 0.257888055122298 no 879 0.254392532874998 1250 5291326 SGTC_36 0335-0881 14.2 µM 0.660651629287986 0.257913255496556 no 880 0.254417875388681 1204 23828853 SGTC_317 4495-0002 170 µM 0.659987075364478 0.258125244635082 no 881 0.25463106173674 1215 15991618 SGTC_3018 9082602 49.47 µM 0.659566514318354 0.25825944801816 no 882 0.254766024430413 1247 17332089 SGTC_3219 9131112 49.47 µM 0.658117202721564 0.258722208362757 no 883 0.255231411320733 1202 17612988 YMR079W SEC14 SGTC_3012 9080433 71.4286 µM 0.658084826133553 0.258732550997925 no 884 0.255241812805515 1264 17688859 SGTC_2408 sulbentine 18.36 µM 0.657856720704267 0.258805424877888 no 885 0.255315101519545 1248 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1917 st066507 28.5 µM 0.657057880102555 0.25906071782938 no 886 0.255571850230817 1255 3156428 SGTC_392 N-ethylmaleimide 8.33 µM 0.656200957494112 0.259334717285665 no 887 0.255847416450598 1216 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1497 4476-2978 41.3 µM 0.655513290321058 0.259554705866299 no 888 0.256068666195934 1272 1528379 SGTC_1607 st000305 50.6 µM 0.6533438418257 0.260249355562447 no 889 0.256767317134734 1279 5457690 SGTC_413 propylparaben 100 µM 0.653251436355812 0.260278964722837 no 890 0.256797097483506 1236 7175 A pharmaceutical preservative. SGTC_254 nsc-64875 3.808 µM 0.650551944363788 0.261144718854868 no 891 0.25766788001463 1292 56993 SGTC_1158 4092-0494 91.8 µM 0.649942673205646 0.261340322737541 no 892 0.25786462612086 1345 1148199 SGTC_3024 9090631 49.47 µM 0.644069813138031 0.263229630458358 no 893 0.259765082091263 1229 25236383 SGTC_909 3448-9333 149 µM 0.643450309587333 0.263429331669645 no 894 0.259965973876613 1249 3344074 SGTC_1136 pergolide 1.05886 µM 0.642744373484589 0.263656989247719 no 895 0.26019499152932 1275 47811 A dopamine receptor agonist. SGTC_484 loperamide 105 µM 0.640822345965564 0.264277332793046 no 896 0.260819056412987 1252 3955 An opioid-receptor agonist. SGTC_510 ag-490 170 µM 0.638551109485153 0.265011342001285 no 897 0.261557497593973 1397 5328779 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.638226184151597 0.265116434709636 no 898 0.261663227400517 1289 551469 SGTC_3302 9125395 16.351 µM 0.63784862352033 0.265238578176795 no 899 0.261786112131236 1277 17599668 SGTC_3101 9120531 49.47 µM 0.637376828889482 0.26539124714015 no 900 0.261939708818586 1335 24824904 SGTC_51 1013-0126 23.419 µM 0.637140739135795 0.265467660631454 no 901 0.262016587155444 1393 1627850 SGTC_1213 1315-0166 115 µM 0.636452751329285 0.265690400396142 no 902 0.262240683825696 1249 768401 SGTC_20 0481-0013 4.944 µM 0.635127798635757 0.266119627784759 no 903 0.262672534048269 1263 182045 SGTC_476 mead acid 10 µM 0.634328300678961 0.266378800316322 no 904 0.262933295387273 1315 5312531 An omega 9 fatty acid. SGTC_1554 st069299 38.7 µM 0.633566783393961 0.266625779388754 no 905 0.263181792090813 1284 24207999 SGTC_3274 9138298 49.47 µM 0.632856965323351 0.266856095324547 no 906 0.263413526404067 1259 17015756 SGTC_509 pifithrin 175 µM 0.632790708360122 0.26687759896786 no 907 0.263435162629799 1353 4817 A p53 inhibitor. SGTC_1677 st019204 53.9 µM 0.632321102461819 0.267030034265482 no 908 0.263588538534748 1247 3945625 SGTC_529 4076-0302 30.3 µM 0.632308727961621 0.267034051654955 no 909 0.263592580731564 1279 5816522 SGTC_1815 st051655 58.2 µM 0.631924429569336 0.267158829566014 no 910 0.263718129602497 1260 5984156 SGTC_2724 maprotiline 69.64 µM 0.630966349822748 0.267470036742086 no 911 0.264031263479455 1283 4011 A tricyclic antidepressant. SGTC_3199 9111318 49.47 µM 0.630962399121026 0.26747132040272 no 912 0.264032555098701 1280 8548020 SGTC_1657 st012939 43.4 µM 0.630561618948581 0.267601557899347 no 913 0.264163600545523 1325 24207257 SGTC_2556 citropten 84.59 µM 0.629129416219759 0.268067227484843 no 914 0.264632166858638 1281 2775 A potential DNA crosslinker. SGTC_394 menadione 8.33 µM 0.627266976540273 0.268673394790182 no 915 0.265242123244004 1282 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3200 9114385 49.47 µM 0.626476119712686 0.268931002723492 no 916 0.265501347731051 1269 17018030 YLR208W SEC13 SGTC_1376 2910-0861 41.3 µM 0.625745010476553 0.269169259171212 no 917 0.265741102622492 1346 1112859 SGTC_1931 st074438 57.1 µM 0.624827558702063 0.269468391329091 no 918 0.266042120601315 1280 2787313 SGTC_1032 k061-1018 98.7 µM 0.62407151758753 0.269715021236848 no 919 0.266290309116288 1434 4005393 SGTC_2487 5918373 44.05 µM 0.623825358554597 0.26979534573056 no 920 0.266371141966179 1338 2876279 SGTC_700 3453-2283 142 µM 0.623213744932645 0.269994974055397 no 921 0.266572035259485 1370 565664 SGTC_504 lovastatin 124 µM 0.622174551914409 0.270334332051215 no 922 0.266913548751026 1268 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1163 k060-0048 49.9 µM 0.622065537781209 0.270369943967991 no 923 0.266949387236441 1302 6809982 SGTC_486 niguldipine 82 µM 0.621295767567689 0.270621473427644 no 924 0.267202518980576 1304 1236 A calcium channel blocker. SGTC_167 3672-0051 66.205 µM 0.619473178193938 0.271217486754661 no 925 0.267802343075039 1260 3237971 SGTC_2904 7225135 42.03 µM 0.619236352173452 0.271294980333415 no 926 0.267880333579653 1373 4446116 SGTC_2891 9063876 19.48 µM 0.617097714068834 0.27199527919745 no 927 0.268585138188863 1282 6472478 SGTC_1215 3852-0577 11.2 µM 0.615755660770954 0.272435194309927 no 928 0.269027897595242 1410 2884876 SGTC_921 1561-0023 372 µM 0.615290966965673 0.272587599808978 no 929 0.269181290968926 1319 24050882 SGTC_3308 9128332 17.569 µM 0.614384725017407 0.272884941429153 no 930 0.269480563603286 1350 17332805 YDL196W YDL196W SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.613503279429811 0.27317430149544 no 931 0.269771807514968 1368 5377381 SGTC_2108 5365811 200 µM 0.611979189957867 0.273674986480705 no 932 0.270275762999157 1377 780283 SGTC_841 0251-0215 91.2 µM 0.610438538599567 0.274181573267608 no 933 0.270785672791786 1360 3888614 SGTC_836 0330-0104 1.35 µM 0.608848709356767 0.274704815516602 no 934 0.271312361991905 1333 46494820 SGTC_2397 5161689 200 µM 0.606564583193521 0.275457424597463 no 935 0.272069955106077 1406 2259942 SGTC_2504 purpurogallin 52.29 µM 0.605767337840763 0.275720351881777 no 936 0.272334630816135 1310 5281571 An antioxidant. SGTC_474 dl-dihydrosphingosine 5 µM 0.605536249702615 0.275796586576331 no 937 0.27241137315836 1366 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2349 9023730 187.07 µM 0.603904395674958 0.27633522080765 no 938 0.272953603095512 1381 4126287 SGTC_2936 9038235 15.59 µM 0.603795482493975 0.276371188689117 no 939 0.272989811640925 1321 4749415 SGTC_3149 9097855 49.47 µM 0.601541930301063 0.27711592478233 no 940 0.273739546445347 1380 25236625 YMR079W SEC14 SGTC_2071 5230951 39.92 µM 0.601413774257758 0.277158306270492 no 941 0.273782213295373 1348 1799272 SGTC_2743 auranofin 4.32 µM 0.600115213043574 0.277587922127522 no 942 0.274214727256407 1307 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1591 genipin 88.4 µM 0.596314164872803 0.278847327452566 no 943 0.275482685007707 1384 442424 A DNA cross-linking agent. SGTC_1397 3532-0190 20.1 µM 0.596027822601965 0.27894231404486 no 944 0.27557832005766 1311 5322280 SGTC_38 0929-0051 58.268 µM 0.595145184616234 0.279235205212786 no 945 0.275873213753574 1378 1379719 SGTC_1830 st055982 50.3 µM 0.593944020804915 0.279634034705495 no 946 0.27627477738062 1324 455313 An antimicrobial agent. SGTC_2999 9069765 71.4286 µM 0.592429118138186 0.280137430676439 no 947 0.276781636311084 1376 2097066 SGTC_2614 arthonioic acid 13.39 µM 0.592082880721075 0.28025254557904 no 948 0.276897544985962 1290 6710684 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.591839348934132 0.280333527264837 no 949 0.276979085496642 1388 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2310 7668677 200 µM 0.590672513776409 0.280721692395966 no 950 0.27736993399435 1396 2197143 SGTC_2970 9090938 41.86 µM 0.589784974168133 0.281017119655342 no 951 0.277667408822367 1386 17217104 SGTC_1072 oxiconazole 14.9 nM 0.589366938884155 0.28115631929187 no 952 0.277807574817277 1359 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3192 9110362 49.47 µM 0.588851961287191 0.281327845068792 no 953 0.277980292761915 1425 16649480 SGTC_3002 9075603 71.4286 µM 0.588675973731005 0.28138647357027 no 954 0.27803932910568 1329 20105405 SGTC_538 2922-0838 53.3 µM 0.588417007460552 0.281472756324854 no 955 0.278126212402517 1421 777039 SGTC_843 0310-0051 143 µM 0.586639570962669 0.282065309397519 no 956 0.278722900227738 1365 2065037 SGTC_3047 9092122 49.47 µM 0.584281786622953 0.282852261666958 no 957 0.279515371954642 1324 17173831 SGTC_720 r052-1644 49.9 µM 0.582975419557096 0.283288738320128 no 958 0.279954923757649 1345 1422863 YOR257W CDC31 SGTC_2546 rhodinyl acetate 100 µM 0.582249735927148 0.283531339483525 no 959 0.280199238395223 1363 6708682 SGTC_3228 9131799 49.47 µM 0.581624726368659 0.283740364359793 no 960 0.28040974203177 1391 17015818 SGTC_3242 9133940 49.47 µM 0.581109795481833 0.283912630533231 no 961 0.280583228604323 1408 17248444 SGTC_1170 0310-0127 64.8 µM 0.580805058496627 0.284014601522376 no 962 0.280685922713856 1395 774975 SGTC_1668 st014914 51.6 µM 0.578510312487763 0.284783030902169 no 963 0.281459818522043 1368 2839556 SGTC_1788 fluconazole 20 µM 0.578132227942541 0.284909733197786 no 964 0.28158742505295 1357 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2572 astragaloside iv 100 µM 0.575856615599232 0.285672895404821 no 965 0.282356051047761 1382 45006101 An anti-inflammatory agent. SGTC_630 4356-0227 183 µM 0.575385329156285 0.285831070177551 no 966 0.282515361969752 1392 779312 SGTC_1028 k015-0029 4.8 µM 0.573443755673925 0.286483146556504 no 967 0.283172135545144 1370 4588309 SGTC_2499 avocadenofuran 51.48 µM 0.572694269376339 0.286735049804279 no 968 0.283425859133545 1318 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2515 chrysin 20.77 µM 0.57231834142958 0.286861439172086 no 969 0.283553163043813 1437 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_137 0438-0332 85.389 µM 0.571693450599418 0.287071589841949 no 970 0.28376483613166 1362 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_956 1185-0240 191 µM 0.571688298910264 0.287073322657003 no 971 0.283766581509205 1392 1416193 SGTC_1310 1188-0297 994 nM 0.569681221564725 0.287748796982957 no 972 0.284446964384602 1349 1588352 SGTC_764 1951-2361 146 µM 0.569303234503913 0.287876091080946 no 973 0.284575186075796 1336 5438930 SGTC_1681 tripelennamine 100 µM 0.567446943913627 0.288501616763455 no 974 0.285205281779013 1358 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.5667053301528 0.288751701864335 no 975 0.285457199454188 1411 368090 SGTC_2341 7987486 176.74 µM 0.566675599676132 0.288761729627468 no 976 0.285467300763955 1436 1258686 SGTC_618 k072-0232 33.2 µM 0.566173931259557 0.288930961592996 no 977 0.285637774684937 1382 5872756 YGL099W LSG1 SGTC_723 4182-0001 115 µM 0.56482923129911 0.289384810431506 no 978 0.286094961268064 1339 744821 YLR208W SEC13 SGTC_102 gallobenzophenone 83.616 µM 0.559369984093385 0.291230788967969 no 979 0.287954621014003 1466 70837 SGTC_632 0781-2353 4.65 µM 0.557215583652237 0.291960783170272 no 980 0.288690071828085 1434 6811515 YHR007C ERG11 SGTC_973 1325-0077 65.9 µM 0.5542591067044 0.292963936507645 no 981 0.289700766163837 1497 2835149 SGTC_1169 aniline yellow 25.8 µM 0.554176977088223 0.292991826479484 no 982 0.289728866494173 1420 6051 A DNA damaging agent. SGTC_3 0833-0587 95.581 µM 0.55337311347253 0.293264871383217 no 983 0.2900039728222 1338 5382644 SGTC_145 3737-0113 38.366 µM 0.553121105063981 0.293350494275273 no 984 0.290090242893297 1398 6849351 SGTC_136 0097-0015 404.482 µM 0.552948892651352 0.293409012178715 no 985 0.290149203308088 1413 4861337 SGTC_3074 9116018 49.47 µM 0.552741165609355 0.293479605174342 no 986 0.290220330347966 1449 17027303 SGTC_3264 9137442 49.47 µM 0.551237965990604 0.293990679848918 no 987 0.290735278569775 1472 17015726 SGTC_2058 5236698 133 µM 0.550136946257527 0.294365277770338 no 988 0.29111272367967 1411 766665 SGTC_1409 3909-8004 61.9 µM 0.549964209681528 0.294424067613079 no 989 0.291171960978939 1409 2119279 SGTC_122 0236-0016 402.397 µM 0.549917099122406 0.294440102345935 no 990 0.291188117783018 1430 6808838 SGTC_1646 st011709 75.6 µM 0.549423185851254 0.294608236847324 no 991 0.291357533026658 1418 5757843 SGTC_144 4161-2749 112.381 µM 0.548910963976857 0.29478265060698 no 992 0.291533276799943 1325 797501 YMR168C CEP3 SGTC_1778 st046819 58.9 µM 0.548026036771201 0.295084084255842 no 993 0.291837012520841 1438 671715 SGTC_1448 4255-0083 152 µM 0.547896646239282 0.295128170576858 no 994 0.291881435898766 1543 5399660 SGTC_1291 0993-0025 5.79 µM 0.546462368415933 0.295617064939265 no 995 0.292374074301863 1487 4353356 SGTC_185 k048-0037 25.491 µM 0.543728108131723 0.296550106995781 no 996 0.293314293515351 1434 6827589 SGTC_1816 st051957 91.6 µM 0.541236789674034 0.29740142017002 no 997 0.294172191360678 1421 674121 SGTC_989 1501-0895 10.3 µM 0.541027842428471 0.297472870640142 no 998 0.294244196045242 1443 2830112 SGTC_1456 k015-0012 13 µM 0.540747735529792 0.297568666775987 no 999 0.294340735615199 1522 2989616 SGTC_813 k007-0158 173 µM 0.53931401727416 0.298059216608781 no 1000 0.294835099205784 1489 6523916 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.538680349853728 0.298276144662166 no 1001 0.295053717381072 1332 641818 YHR062C RPP1 SGTC_2247 cerulenin 830 nM 0.53644572667999 0.299041712840959 no 1002 0.295825267937176 1479 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2082 5219693 150 µM 0.535990125604744 0.299197908400749 no 1003 0.295982687437745 1405 2834649 SGTC_2030 5175110 200 µM 0.53464181884426 0.299660370617859 no 1004 0.29644878018856 1487 2831986 SGTC_2635 hydroquinidine 100 µM 0.53432773161466 0.299768147394001 no 1005 0.296557404497859 1456 442912 An experimental heart treatment. SGTC_2785 7756463 72.73 µM 0.533636199162833 0.300005503635426 no 1006 0.296796629170317 1380 2201551 SGTC_1292 0kpi-0043 232 µM 0.532636999286297 0.300348611373439 no 1007 0.297142442443172 1414 3333905 SGTC_3033 9090887 49.47 µM 0.532259262944864 0.300478365590238 no 1008 0.297273221250078 1394 19325384 SGTC_2278 7948257 134.34 µM 0.528488100950553 0.301775163234153 no 1009 0.298580301842565 1445 1247028 SGTC_967 1306-0166 352 µM 0.526329861124055 0.302518451915488 no 1010 0.299329519458576 1503 4437607 SGTC_2469 5655019 90.81 µM 0.526098992573882 0.302598010638067 no 1011 0.29940971429711 1550 2788239 SGTC_3296 9122258 64.045 µM 0.526056087623578 0.302612796981025 no 1012 0.299424618897087 1468 4730474 SGTC_974 1326-0144 138 µM 0.525463343227062 0.302817107746147 no 1013 0.299630564709686 1429 5411856 SGTC_875 0709-0210 25.7 µM 0.525280972527938 0.302879980818054 no 1014 0.29969394132423 1470 6251364 SGTC_757 1066-0008 322 µM 0.524500060323172 0.303149269676228 no 1015 0.29996538893292 1510 6842497 SGTC_1175 0741-0056 27.6 µM 0.524397139114438 0.303184768891224 no 1016 0.300001172974617 1542 765927 SGTC_1256 0570-0116 285 µM 0.523414246233717 0.303523878385565 no 1017 0.300343006206681 1423 410638 SGTC_1246 0422-0085 105 µM 0.523028856572709 0.303656888523727 no 1018 0.300477086120683 1481 264295 SGTC_1640 st009078 66.4 µM 0.522165750614283 0.30395486797902 no 1019 0.300777465098286 1516 690618 SGTC_948 3448-0295 75.3 µM 0.521653314146541 0.304131843653507 no 1020 0.300955867809387 1456 678569 SGTC_1663 st014140 55.4 µM 0.521453401624809 0.304200898130419 no 1021 0.301025479491002 1521 4207120 SGTC_68 0986-0284 82.829 µM 0.520940956919284 0.304377940449304 no 1022 0.301203951365419 1392 423278 YIL048W NEO1 SGTC_1809 st050081 57.6 µM 0.520031833647414 0.304692142358205 no 1023 0.301520693851011 1527 5036894 SGTC_1102 cgs 12066b 26.1 µM 0.519223799755051 0.304971527781144 no 1024 0.301802342091065 1453 6438352 A 5-HT1B full agonist. SGTC_1118 chelidonine 707.474 nM 0.51698398363536 0.305746559730411 no 1025 0.302583669707096 1552 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2091 4-phenylthiadiazole 200 µM 0.516414122095856 0.305943885077992 no 1026 0.302782602276369 1471 270010 SGTC_2728 chlorpromazine 9.18 µM 0.516388816055743 0.305952649080359 no 1027 0.302791437702485 1473 2726 A thorazine and dopamine antagonist. SGTC_544 k015-0020 52.4 µM 0.513585057599598 0.306924335439599 no 1028 0.303771064377682 1462 3008304 SGTC_183 3914-0051 30.55 µM 0.513085482804505 0.307097613626271 no 1029 0.303945762983404 1566 1596232 SGTC_1870 st057514 26.5 µM 0.512125505626904 0.307430703924407 no 1030 0.3042815875005 1463 5393161 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.511734161696929 0.307566536989176 no 1031 0.304418536990874 1432 75037 A free radical scavenger. SGTC_2953 9074162 66.49 µM 0.509981090619966 0.308175340821333 no 1032 0.305032354731713 1570 16451992 SGTC_639 0833-0042 114 µM 0.509665286571213 0.308285068952106 no 1033 0.305142988298949 1435 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1111 tnp00062 510.699 nM 0.509663682711768 0.308285626267032 no 1034 0.305143550213998 1590 676306 SGTC_1581 himbacine 57.9 µM 0.508184759359761 0.308799715879582 no 1035 0.305661889025682 1451 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1654 st012436 41.8 µM 0.507472754444165 0.309047350169495 no 1036 0.305911574305297 1475 4323132 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.506614594117127 0.309345932456499 no 1037 0.306212633150173 1538 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1263 0774-1208 64.8 µM 0.504454528488036 0.310098047645713 no 1038 0.3069710040728 1592 906585 SGTC_29 0299-0004 12.984 µM 0.503778921248517 0.31033345134108 no 1039 0.307208370847399 1407 16871 A napthoquinone isolated from Swertia calycina. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.50164515451551 0.311077435594397 no 1040 0.307958575278852 1449 688803 SGTC_2570 licareol 100 µM 0.501080206480933 0.311274546530049 no 1041 0.308157338235255 1453 443158 SGTC_2658 polymyxin b sulfate 77.05 µM 0.500447302288114 0.311495431721389 no 1042 0.308380076713947 1456 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_824 1304-0008 100 µM 0.499491564808821 0.311829115163251 no 1043 0.308716563874702 1490 768245 SGTC_1614 st002383 48.6 µM 0.499272777426676 0.311905523707882 no 1044 0.308793615109636 1482 1947235 SGTC_1079 idarubicin 2.36 µM 0.496754338002827 0.312785636989493 no 1045 0.309681149463036 1487 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2087 5276107 200 µM 0.496102962741731 0.313013445709567 no 1046 0.309910884507683 1456 144405 SGTC_1523 st012844 44.7 µM 0.496019852573411 0.313042517381816 no 1047 0.309940202167639 1511 4274103 SGTC_362 0310-0100 9.03 µM 0.495538582120004 0.313210887103711 no 1048 0.310109997252806 1490 790235 SGTC_126 0417-1624 672.48 µM 0.495349995192024 0.313276873787285 no 1049 0.310176542891011 1535 41912 YDL195W SEC31 SGTC_573 3702-0553 84.7 µM 0.494333221178551 0.313632746618752 no 1050 0.310535433448441 1468 1222756 SGTC_230 MPP+ 141.667 µM 0.492881133815121 0.314141280738456 no 1051 0.311048289261105 1444 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_587 k089-0003 57 µM 0.490543609664216 0.314960644204927 no 1052 0.311874639216791 1494 9659696 SGTC_2845 9003024 42.97 µM 0.487867647690242 0.31589975802711 no 1053 0.312821795753871 1573 2990173 SGTC_1837 st055472 66.5 µM 0.487692156578974 0.315961387272139 no 1054 0.312883954108945 1552 676091 SGTC_2245 6637752 200 µM 0.487599817234689 0.315993817202628 no 1055 0.312916662527018 1618 681890 SGTC_3133 9127736 49.47 µM 0.487398783899937 0.316064425774955 no 1056 0.312987877594668 1554 27243420 SGTC_564 3555-0129 330 µM 0.487232237599487 0.316122926610977 no 1057 0.313046881085804 1458 563260 SGTC_1860 st056228 74.6 µM 0.48705773913281 0.316184225653375 no 1058 0.313108706981483 1464 688679 SGTC_2118 5526350 200 µM 0.486316443708503 0.316444689404151 no 1059 0.313371411137239 1541 743594 SGTC_1808 st050063 61.5 µM 0.485781427722471 0.316632730794886 no 1060 0.313561071764096 1551 4011993 SGTC_457 grayanotoxin iii 135 µM 0.485566494477995 0.316708286458412 no 1061 0.313637278461875 1463 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_229 benomyl 22.8748 µM 0.485177237520756 0.316845141747138 no 1062 0.313775313592405 1474 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.484872528183811 0.316952289204532 no 1063 0.313883385327875 1607 5024745 SGTC_2920 7982904 15.77 µM 0.483633643766219 0.317388086379049 no 1064 0.314322946759106 1459 6456808 SGTC_37 0566-0070 1.56 µM 0.48334249111012 0.317490540703771 no 1065 0.314426287204149 1599 1626686 SGTC_934 2950-0684 338 µM 0.482961427847928 0.317624654987496 no 1066 0.31456156209789 1613 1121253 SGTC_93 0109-0045 59.227 µM 0.481501485538822 0.31813869952228 no 1067 0.315080062088385 1520 88733 SGTC_2532 xanthone 78.9 µM 0.481064672901456 0.318292569074236 no 1068 0.315235267444037 1573 7020 An insecticide. SGTC_2851 9015922 71.43 µM 0.479904786665337 0.318701297230371 no 1069 0.315647548727349 1572 2996893 SGTC_583 1488-1091 88.9 µM 0.479450666989151 0.318861382973668 no 1070 0.315809028012096 1569 4303273 SGTC_1824 st053723 68.6 µM 0.476750680166425 0.319813876293487 no 1071 0.316769834743661 1464 675225 SGTC_9 0092-0002 10.449 µM 0.476603657470292 0.319865776723876 no 1072 0.316822189242681 1511 759368 SGTC_3335 9143315 29.6265 µM 0.475346243106373 0.32030980009624 no 1073 0.317270101849169 1501 4899691 SGTC_1876 myriocin 605 nM 0.474490032918271 0.320612295938835 no 1074 0.317575251927925 1613 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_157 1348-1695 65.819 µM 0.473958573284782 0.320800118591737 no 1075 0.31776472451588 1486 5380510 SGTC_2255 7941087 197.44 µM 0.472313036236893 0.321381957073472 no 1076 0.318351683367052 1624 935561 SGTC_2450 5739737 12.93 µM 0.471902439446601 0.32152720668203 no 1077 0.318498213382446 1514 2262825 SGTC_2115 tiliquinol 12.7705 µM 0.470255452662942 0.322110106345303 no 1078 0.319086260100843 1548 71208 A bioactive hydroxyquinoline. SGTC_1922 5578187 25 µM 0.470085431669827 0.322170304935544 no 1079 0.319146991039246 1624 1350412 SGTC_748 act1.228 77.9 µM 0.469251424600856 0.322465665719815 no 1080 0.319444965895012 1448 4421505 YNR035C ARC35 SGTC_2239 6685329 187.64 µM 0.466372394694369 0.323486124836041 no 1081 0.320474483764714 1511 805680 SGTC_819 1013-0258 27.7 µM 0.465284165790059 0.32387218919011 no 1082 0.320863986243808 1517 5753198 SGTC_2768 sulfasalazine 50.2 µM 0.463561171019934 0.324483833119052 no 1083 0.321481089500981 1670 5384001 An antioxidant and salicylic acid derivative. SGTC_2311 7694451 200 µM 0.461698982322521 0.32514542208465 no 1084 0.322148600490118 1595 2163142 SGTC_2461 5755302 26.15 µM 0.460608180760633 0.325533212881922 no 1085 0.322539870622744 1637 2788904 SGTC_892 0929-0076 29 µM 0.459987055845736 0.32575411340998 no 1086 0.322762755795469 1526 5751038 SGTC_2210 7115885 190.385 µM 0.459228549751128 0.326023955980214 no 1087 0.323035025358345 1535 2927039 SGTC_3181 9108277 49.47 µM 0.458553245856635 0.326264275621881 no 1088 0.323277508897275 1481 17097298 SGTC_2441 5730946 39.09 µM 0.458286823176944 0.326359107016905 no 1089 0.323373194808497 1620 1774275 SGTC_1637 st007924 17.4 µM 0.456076150474391 0.327146413913007 no 1090 0.324167609803367 1517 683336 SGTC_2619 obliquin 87.91 µM 0.4555169079164 0.327345704168283 no 1091 0.324368703210378 1615 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1266 0828-0227 32.9 µM 0.454682660306655 0.327643085990143 no 1092 0.324668778614314 1591 3913820 SGTC_1610 st001799 48.1 µM 0.454389501113428 0.327747613574527 no 1093 0.324774253800444 1486 621897 SGTC_2479 5617353 43.85 µM 0.453751976342448 0.327974973260257 no 1094 0.325003676113773 1618 2731746 SGTC_801 0866-0028 10.1 µM 0.453677631509848 0.328001490920794 no 1095 0.32503043447716 1555 6849771 SGTC_551 k048-0028 34.9 µM 0.453221808088059 0.328164095088928 no 1096 0.325194515219388 1632 6836383 SGTC_1602 st001878 87.6 µM 0.453191184262194 0.328175020578498 no 1097 0.325205539958212 1590 595405 YLR310C CDC25 SGTC_2782 7736369 71.43 µM 0.45108088166714 0.328928254959654 no 1098 0.325965628135415 1562 2950836 YOL077C BRX1 SGTC_812 4251-0442 148 µM 0.449635150677606 0.329444684054191 no 1099 0.326486769101651 1555 5723007 SGTC_737 1950-0117 57.9 µM 0.448554637215748 0.329830866521303 no 1100 0.32687648186006 1612 5393513 SGTC_3005 9076496 71.4286 µM 0.448390046861368 0.329889708109484 no 1101 0.326935861857799 1588 21368410 SGTC_924 2046-0044 21.3 µM 0.446275065951046 0.33064619483097 no 1102 0.327699282496579 1509 3623589 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.445936601510232 0.330767321189452 no 1103 0.327821521147992 1654 756377 SGTC_160 3453-0671 289.699 µM 0.445094138604035 0.331068890543199 no 1104 0.328125862245483 1487 5322268 SGTC_1983 st071813 46.9 µM 0.444999918093749 0.331102624685216 no 1105 0.328159906658143 1564 11838595 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.443414587473859 0.331670432297296 no 1106 0.328732943263619 1530 803109 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.438412917334868 0.333464379475796 no 1107 0.330543492134702 1562 442882 SGTC_2147 5545932 89.7195 µM 0.437078543595485 0.333943625236642 no 1108 0.331027193690484 1583 797404 SGTC_1031 k035-0009 16 µM 0.436532616558136 0.334139775303696 no 1109 0.331225169972346 1696 5180959 SGTC_1396 3511-0007 98.6 µM 0.43652556535464 0.33414230907801 no 1110 0.331227727346354 1562 X1396 SGTC_1053 3366-3204 134 µM 0.436042117694777 0.334316048826926 no 1111 0.331403085893746 1539 3632071 YPR165W RHO1 SGTC_1061 3448-9325 110 µM 0.435851889968853 0.334384421943848 no 1112 0.331472096381015 1569 723482 SGTC_1978 st071761 42 µM 0.434871143738053 0.334737016464102 no 1113 0.331827980564644 1517 5147680 SGTC_2881 9058953 51.95 µM 0.434222478399928 0.334970302510491 no 1114 0.332063445713123 1488 17122249 SGTC_3237 9133362 49.47 µM 0.433786147737799 0.335127260334739 no 1115 0.33222187081587 1630 43845137 SGTC_454 lyso-paf C-16 6.67 µM 0.431368602724178 0.335997426027312 no 1116 0.333100187769154 1482 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2514 salinomycin 42.74 µM 0.431232305245137 0.336046510873877 no 1117 0.333149733260679 1732 23682228 A polyether potassium ionophore. SGTC_765 1319-0117 244 µM 0.430634230362753 0.336261928779623 no 1118 0.333367173854529 1517 3487746 YGL099W LSG1 SGTC_2682 pyrogallin 40.03 µM 0.429630139056401 0.336623708811298 no 1119 0.33373235474571 1611 822798 An ATP competetive kinase inhibitor. SGTC_225 nsc-122657 1.016 µM 0.427728151381461 0.337309420651655 no 1120 0.334424525861375 1613 275685 SGTC_165 k038-0023 64.381 µM 0.427356708793593 0.337443397731736 no 1121 0.334559767015018 1533 46368543 SGTC_1996 st072960 66.8 µM 0.426548791478695 0.337734879739502 no 1122 0.334854001447613 1644 1719405 SGTC_2506 ethyl hematommate 54.16 µM 0.426498005318468 0.337753205724841 no 1123 0.334872500587585 1507 3940691 An allergen. SGTC_2407 paclitaxel 400 µM 0.425915462717988 0.337963441424001 no 1124 0.335084723603116 1716 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1417 3966-0327 90.4 µM 0.423383488913539 0.338877800348878 no 1125 0.336007744705077 1630 651118 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.422854240721057 0.339069045316809 no 1126 0.336200805311996 1638 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2013 4024628 200 µM 0.422623017268717 0.339152611428268 no 1127 0.336285165202686 1628 5230760 SGTC_379 3970-0972 5.9 µM 0.421882075700099 0.339420447268725 no 1128 0.336555546887694 1621 2898042 YBL034C STU1 SGTC_308 4092-1169 104 µM 0.420982642291076 0.339745683818974 no 1129 0.336883878411755 1603 2268590 YDL196W YDL196W SGTC_3034 9090421 49.47 µM 0.420084039264201 0.3400707392887 no 1130 0.33721203098377 1648 17173761 SGTC_2376 9072922 81.32 µM 0.419594525466986 0.340247863231983 no 1131 0.33739084416758 1623 17087968 SGTC_1571 st070080 73.4 µM 0.418252646127086 0.340733584794027 no 1132 0.337881203925918 1701 4315245 SGTC_2565 isoliquiritigenin 100 µM 0.415724945530755 0.341649256445843 no 1133 0.33880564261638 1513 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_469 w7 172 µM 0.415482933811073 0.341736975355121 no 1134 0.338894202971724 1640 45115570 A P450 inhibitor. SGTC_561 1550-0330 72.9 µM 0.413603270363001 0.342418563698916 no 1135 0.339582338891305 1573 6812934 SGTC_2664 lyso-paf C-16 73.48 µM 0.412826313641053 0.342700447590804 no 1136 0.339866935526791 1616 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2439 5492030 7.2 µM 0.412780942129103 0.3427169113174 no 1137 0.339883557781907 1695 5722370 SGTC_2879 9041815 71.43 µM 0.412072712759341 0.342973941567092 no 1138 0.340143064220873 1584 4942971 SGTC_2307 7538926 6.34 µM 0.412039188402742 0.342986110012459 no 1139 0.340155349953632 1604 96582 SGTC_2617 dihydrotanshinone i 20.83 µM 0.41190179221331 0.343035982858054 no 1140 0.340205703561367 1576 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2952 9073731 13.78 µM 0.411593055077733 0.343148059984286 no 1141 0.340318861407675 1546 16457353 SGTC_3294 9122953 26.2835 µM 0.411491125500769 0.343185065282157 no 1142 0.340356223632901 1567 16459826 SGTC_1886 st057356 49.9 µM 0.40842863926405 0.344297593769849 no 1143 0.341479505535752 1543 24207747 SGTC_793 0488-0545 106 µM 0.408244420102228 0.344364559312927 no 1144 0.34154711975133 1572 292548 SGTC_1094 duloxetine 25.4 µM 0.407938744390152 0.344475686314348 no 1145 0.341659323552311 1623 60834 A selective serotonin reuptake inhibitor. SGTC_1665 st014639 11.4 µM 0.407712523495336 0.344557936526877 no 1146 0.341742371034914 1683 981133 YIL048W NEO1 SGTC_972 1319-0219 195 µM 0.407513688467042 0.344630235755984 no 1147 0.341815371274322 1576 23903702 SGTC_1529 apigenin 74 µM 0.407160219528552 0.344758776073856 no 1148 0.341945158369484 1708 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2962 9082311 13.18 µM 0.406796225829827 0.344891162492144 no 1149 0.342078829479703 1546 16459453 SGTC_1564 D-Arginine 115 µM 0.406792469999916 0.344892528606211 no 1150 0.342080208853908 1516 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1979 st071809 45.3 µM 0.406261286377884 0.345085757239463 no 1151 0.342275313716578 1681 4976333 SGTC_1943 st076331 65.2 µM 0.405822807206674 0.345245293222043 no 1152 0.342436399767313 1656 24208415 SGTC_2144 5628481 200 µM 0.405751250834339 0.345271330858168 no 1153 0.342462690472807 1631 2818399 SGTC_3119 9125183 49.47 µM 0.405314499089103 0.345430270145695 no 1154 0.342623175066544 1631 22695334 SGTC_1427 4048-4900 550 nM 0.400000136730049 0.347366407812567 no 1155 0.344578208036083 1717 24132586 SGTC_1218 1348-1416 30.7 µM 0.399796767008232 0.34744057939272 no 1156 0.344653106073816 1628 6787668 SGTC_263 alizarin 107.927 µM 0.399287609332967 0.347626301429221 no 1157 0.344840647961383 1659 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3088 9117578 49.47 µM 0.399077449931127 0.347702970534366 no 1158 0.344918068679324 1643 678341 SGTC_790 1575-0012 79.1 µM 0.39729111218676 0.34835490287263 no 1159 0.345576400337567 1697 378741 YLR208W SEC13 SGTC_839 0122-0028 230 µM 0.394710495687399 0.349297502162615 no 1160 0.346528277996566 1652 759448 SGTC_3093 9117344 49.47 µM 0.394405962713967 0.349408797745687 no 1161 0.34664067111749 1639 24824913 SGTC_543 3844-1095 191 µM 0.393854257547126 0.349610458632022 no 1162 0.346844321756071 1720 4230703 SGTC_3233 9132340 49.47 µM 0.392748629016021 0.350014718923477 no 1163 0.347252574996739 1573 17682950 SGTC_822 1487-0950 154 µM 0.39267072244648 0.35004321097859 no 1164 0.347281348683179 1721 1958375 SGTC_2447 5741742 33.78 µM 0.391859197265592 0.35034005281217 no 1165 0.34758112631146 1711 1776504 SGTC_2524 avocatin b 10.57 µM 0.390559797107253 0.350815541208611 no 1166 0.348061323578352 1722 6710748 SGTC_900 1112-0045 141 µM 0.389147421121611 0.351332635873935 no 1167 0.348583547852426 1600 56211 YIL048W NEO1 SGTC_1352 1496-0991 99 µM 0.387881284454971 0.351796423927517 no 1168 0.349051944398273 1630 3000039 SGTC_3350 9150499 3.57 µM 0.387564430395511 0.351912522660216 no 1169 0.349169197896648 1622 4910996 YPR165W RHO1 SGTC_2941 9056145 11.23 µM 0.387504077361407 0.351934638226431 no 1170 0.349191533484833 1630 2119517 SGTC_3001 9076041 71.4286 µM 0.386053715515427 0.35246625453021 no 1171 0.349728443648822 1631 16004211 SGTC_1268 0828-0275 2.46 µM 0.385940178432193 0.352507882647302 no 1172 0.349770486701326 1701 745337 SGTC_1875 nocodazole 6 µM 0.385564920376927 0.352645482738275 no 1173 0.349909458758278 1733 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2269 7935389 174.42 µM 0.38307580791512 0.353558680957151 no 1174 0.350831778228474 1585 97605 SGTC_1332 1480-0653 17.5 µM 0.38215576479028 0.353896437454834 no 1175 0.351172915366412 1754 5749438 SGTC_2824 7998404 51.95 µM 0.381779037268463 0.354034770881486 no 1176 0.351312634481486 1673 837851 SGTC_2275 7947463 200 µM 0.380554315531617 0.354484618769953 no 1177 0.351766992893045 1707 1225414 SGTC_415 dibenzyl ketone 100 µM 0.37993228064134 0.354713173841609 no 1178 0.35199784220189 1758 7593 SGTC_1008 4106-0037 6 µM 0.376368333538766 0.356023685678736 no 1179 0.353321542211779 1666 2905394 SGTC_560 2332-1943 155 µM 0.373586248299419 0.357047880718763 no 1180 0.354356083302635 1673 21177716 SGTC_2060 5238662 140 µM 0.373384783719935 0.35712208787896 no 1181 0.354431041405708 1653 790130 SGTC_1766 st045414 44.774 µM 0.372431770784746 0.357473192445654 no 1182 0.354785701418197 1660 253960 SGTC_1612 st002233 45.4 µM 0.371871056183512 0.3576798247019 no 1183 0.354994427997421 1676 1035021 SGTC_559 1550-0661 158 µM 0.371711030684289 0.357738804300589 no 1184 0.355054005638176 1716 5830875 SGTC_2344 7990960 76.95 µM 0.371301070652359 0.357889916203826 no 1185 0.355206650301715 1674 140813 SGTC_3258 9138477 49.47 µM 0.37095173244307 0.358018700385728 no 1186 0.355336741352175 1702 4970355 SGTC_2122 5258151 111.688 µM 0.370407731780387 0.358219279413367 no 1187 0.355539356871416 1638 2173356 SGTC_3073 9114972 49.47 µM 0.370355793183852 0.358238431792547 no 1188 0.355558703773869 1781 41905075 SGTC_1879 gemcitabine 100 µM 0.370089882560401 0.358336492032954 no 1189 0.355657760159484 1708 60750 A nucleoside analog which inhibits DNA replication. SGTC_787 4152-0075 138 µM 0.368410777446819 0.35895591356475 no 1190 0.356283481245441 1701 9566539 SGTC_1019 4262-0212 3.4 µM 0.365622249350789 0.359985420140428 no 1191 0.357323485202868 1798 4677213 SGTC_2886 9058944 51.95 µM 0.36517606052736 0.360150244702112 no 1192 0.357489993546777 1653 4949929 SGTC_2117 5521686 200 µM 0.364695583328077 0.360327764649466 no 1193 0.357669327935512 1641 803312 SGTC_1063 disulfiram 1.84 µM 0.364405317741887 0.360435022484156 no 1194 0.357777682544668 1680 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_187 1488-2104 32.728 µM 0.362265515840552 0.36122605236709 no 1195 0.358576812454368 1749 2852859 SGTC_2899 9053889 58.44 µM 0.362251879458069 0.361231095295397 no 1196 0.358581907085104 1799 6470052 SGTC_1014 4130-3005 69.3 µM 0.360324977379408 0.361943933190436 no 1197 0.359302061403189 1651 743608 SGTC_600 1495-0418 41.6 µM 0.358833775987034 0.362495917106192 no 1198 0.359859721761228 1696 5377768 SGTC_1324 1418-0026 34.4 µM 0.356446726039062 0.363380103658913 no 1199 0.360753020926515 1727 1372513 SGTC_2794 7785382 27.27 µM 0.356131157318029 0.363497047999405 no 1200 0.36087117234776 1853 2205081 SGTC_869 0564-0080 44.1 µM 0.354492768014837 0.364104411157102 no 1201 0.361484811453501 1655 6843321 SGTC_1328 1441-0025 69.2 µM 0.354012559512394 0.364282492819224 no 1202 0.361664735423574 1597 4562601 SGTC_2602 kawain 100 µM 0.352899107939078 0.364695520533181 no 1203 0.362082039811939 1711 5369129 SGTC_1309 pyrazolanthrone 13.4 µM 0.352332623848591 0.36490571449596 no 1204 0.36229441224155 1786 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3154 9100113 49.47 µM 0.351992410156113 0.365031970332118 no 1205 0.362421977258418 1654 25237525 SGTC_1421 4029-0249 71.4 µM 0.349176002556402 0.366077721023976 no 1206 0.363478590466346 1837 2894095 SGTC_3028 9087778 49.47 µM 0.348269575442469 0.366414495531047 no 1207 0.363818870282585 1634 17217395 SGTC_1710 st031758 61.5 µM 0.347945722360563 0.366534845074246 no 1208 0.363940473321147 1784 5394341 SGTC_2126 5251174 33.877 µM 0.347828172793361 0.366578531823277 no 1209 0.363984615196893 1885 790722 SGTC_1194 1488-0194 225 µM 0.347281747958083 0.366781630753869 no 1210 0.364189830767465 1710 1391452 SGTC_751 0833-0568 350 µM 0.347157001207091 0.366828002713668 no 1211 0.364236686178982 1732 6954252 SGTC_1025 k007-0731 70 µM 0.345896611179769 0.367296634893201 no 1212 0.364710207761491 1678 6256118 SGTC_2859 9028643 45.46 µM 0.344895882275431 0.367668861988881 no 1213 0.365086323181433 1798 17151580 SGTC_54 0159-0055 9 µM 0.344857488661678 0.367683145201764 no 1214 0.365100755681894 1822 3319099 SGTC_2399 5884133 200 µM 0.344302155457977 0.367889761017588 no 1215 0.365309531728314 1642 722445 SGTC_3094 9117742 49.47 µM 0.343071574100502 0.368347744038969 no 1216 0.365772307695909 1654 17149698 SGTC_3045 9092950 49.47 µM 0.34191046877306 0.36878004189985 no 1217 0.366209135495528 1844 44120432 SGTC_200 k038-0079 37.545 µM 0.340264991609302 0.36939296341309 no 1218 0.366828489271438 1745 3436683 SGTC_14 0354-0009 295 µM 0.339737091430881 0.369589670661554 no 1219 0.367027263233922 1757 1713507 SGTC_2065 5221596 34.26 µM 0.338675257768728 0.369985436645364 no 1220 0.367427190850964 1754 788581 SGTC_2083 5306046 65.942 µM 0.338378400980511 0.370096105575268 no 1221 0.367539024342726 1699 539837 SGTC_1744 st037937 38.9 µM 0.338184564292532 0.370168374167639 no 1222 0.367612053609438 1769 1016152 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.338036657571816 0.370223521664735 no 1223 0.367667781674605 1717 4620898 SGTC_118 0083-0097 135.343 µM 0.337941713500372 0.370258923273499 no 1224 0.36770355602325 1718 5207356 SGTC_2158 5657123 3.6195 µM 0.337617696706106 0.370379747050565 no 1225 0.367825652221826 1776 2858827 SGTC_2541 muurolladie-3-one 83.07 µM 0.336885816007736 0.370652707704263 no 1226 0.368101489078996 1755 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_367 0335-0881 7.1 µM 0.336428659975407 0.370823240688041 no 1227 0.368273820100549 1805 23828853 SGTC_2404 5161160 200 µM 0.336088381377466 0.370950191341598 no 1228 0.368402109834692 1755 2831543 SGTC_522 1273-0010 11.6 µM 0.336059178277274 0.370961087047232 no 1229 0.368413120490884 1760 5705015 SGTC_848 0368-0089 85.6 µM 0.335787171054584 0.371062578180196 no 1230 0.368515682531971 1791 762535 SGTC_2378 9074213 121.43 µM 0.335065100373433 0.371332040145523 no 1231 0.36878798926658 1696 657714 SGTC_3143 9086658 49.47 µM 0.332585398029311 0.372257893724217 no 1232 0.369723633582655 1710 25236626 SGTC_533 1222-0222 6.71 µM 0.33185553194902 0.372530546905449 no 1233 0.369999174818567 1838 3982874 SGTC_1676 st018489 23.4 µM 0.33090879265483 0.372884311730069 no 1234 0.370356690106105 1735 3696235 SGTC_3125 9127534 49.47 µM 0.329968935944818 0.373235610828766 no 1235 0.370711717140562 1759 1639235 SGTC_2068 5226020 147 µM 0.329862305759143 0.3732754736609 no 1236 0.370752003218443 1693 1810509 SGTC_1511 0906-3109 28.5 µM 0.328663141908382 0.373723864669971 no 1237 0.371205158224914 1724 2882180 SGTC_3250 9135583 49.47 µM 0.327885382797132 0.374014775583712 no 1238 0.371499163085332 1826 7699353 SGTC_1321 1326-2144 215 µM 0.326558531345698 0.374511233090796 no 1239 0.372000906258535 1845 3513030 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.32619362556478 0.374647803520231 no 1240 0.372138931968975 1816 688751 SGTC_2435 5706476 10.6 µM 0.326049976458696 0.374701570260908 no 1241 0.372193271790197 1896 5725375 SGTC_286 k060-0067 22.9 µM 0.325732944807712 0.374820241355728 no 1242 0.372313208052628 1732 5985051 SGTC_1701 st028638 40.4 µM 0.324307728144286 0.375353873872483 no 1243 0.372852534697322 1836 3490878 SGTC_1133 3473-0247 50 µM 0.320404444277636 0.376816568196721 no 1244 0.374330878473077 1650 711311 SGTC_1855 st056195 39.6 µM 0.319277144731167 0.377239336323431 no 1245 0.374758181156286 1868 4028379 SGTC_1530 rhein 70.4 µM 0.318373438058836 0.377578357327576 no 1246 0.375100842109339 1776 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2290 7904846 200 µM 0.318215982856592 0.377637435511205 no 1247 0.375160554926617 1703 2962154 SGTC_1487 3970-0795 2.82 µM 0.316449534653007 0.378300413914798 no 1248 0.375830661962625 1785 3765103 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.315666580103558 0.37859438499768 no 1249 0.376127797902354 1753 521171 SGTC_95 0471-0001 561.058 µM 0.314450747344436 0.379051025399788 no 1250 0.376589359237948 1662 4015405 SGTC_2990 9074105 71.4286 µM 0.314019841068541 0.379212905004119 no 1251 0.376752984718133 1759 6502001 SGTC_2221 6807166 181.081 µM 0.313367003168997 0.379458198547499 no 1252 0.37700092515121 1812 674925 SGTC_1863 st057641 20.1 µM 0.311583746027354 0.380128476345913 no 1253 0.377678444250618 1895 3921635 SGTC_608 k048-0125 159 µM 0.309756805776143 0.380815546973748 no 1254 0.378372950516014 1862 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3272 9137413 49.47 µM 0.309654889223035 0.38085388656153 no 1255 0.378411705407591 1670 17614870 SGTC_1908 st060353 56.5 µM 0.309333664398407 0.380974734519526 no 1256 0.378533862685228 1937 4227716 SGTC_3217 9129673 49.47 µM 0.309332342121011 0.380975231997371 no 1257 0.378534365553797 1772 17248312 SGTC_2360 9040895 200 µM 0.308705392315393 0.381211130247537 no 1258 0.378772820790141 1729 4914414 SGTC_1004 4084-0029 199 µM 0.30730912310474 0.381736653736434 no 1259 0.379304046112381 1896 716894 YLR208W SEC13 SGTC_2805 7950783 58.44 µM 0.307003112225253 0.38185185832898 no 1260 0.379420501665062 1800 1178958 YDL195W SEC31 SGTC_1723 st034307 2.5525 µM 0.305404879961737 0.382453718192488 no 1261 0.380028902777517 1730 867466 SGTC_3305 9127027 53.8275 µM 0.305244543892197 0.382514113006139 no 1262 0.380089954531047 1784 41905295 SGTC_2281 7943571 200 µM 0.304482003474926 0.382801383076004 no 1263 0.38038035071736 1945 1244024 SGTC_2557 derrustone 83.84 µM 0.301241932670021 0.384022724736097 no 1264 0.381615008171548 1713 629853 An antioxidant. SGTC_850 0388-0143 75.9 µM 0.301145435078699 0.384059117148754 no 1265 0.38165179797389 1762 67273 SGTC_339 3091-4833 71.4 µM 0.30110708181645 0.384073581708184 no 1266 0.381666420490062 1820 3240077 SGTC_1232 0279-0259 161 µM 0.300332381967196 0.384365786759209 no 1267 0.381961817701035 1740 1560000 SGTC_77 0828-0286 12.516 µM 0.300072210696408 0.384463934173179 no 1268 0.382061037829619 1801 745345 SGTC_1254 0550-0035 264 µM 0.299254200779811 0.384772569731017 no 1269 0.382373048342536 1862 15121435 SGTC_602 3130-1533 38.1 µM 0.29842129190022 0.385086901719032 no 1270 0.382690820197821 1884 720941 SGTC_1339 1486-1321 22.7 µM 0.298341681704372 0.385116949816783 no 1271 0.382721197262852 1764 3469382 SGTC_2046 4110841 106 µM 0.297900826794072 0.38528335871744 no 1272 0.382889428448423 1907 44119630 YMR134W ERG29 SGTC_2636 apigenin dimethyl ether 100 µM 0.297128383966063 0.385574982573946 no 1273 0.383184247555206 1822 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_999 SEC7.066 22.7 µM 0.296259583016046 0.385903062253064 no 1274 0.383515924627203 1826 740511 YDR170C SEC7 SGTC_273 hydroxyurea 18.1 mM 0.295566383611203 0.386164889215322 no 1275 0.383780624572072 1815 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1727 st034309 9.9045 µM 0.295371504386852 0.386238506000452 no 1276 0.383855049468948 1920 870305 SGTC_284 0988-0104 32.6 µM 0.294689684983436 0.386496099547303 no 1277 0.384115471820372 1862 4666532 SGTC_128 0906-2981 13.371 µM 0.294496745316465 0.386569001855193 no 1278 0.384189175035136 1889 6740226 SGTC_3243 9134147 49.47 µM 0.293342305985494 0.387005290643261 no 1279 0.384630259836212 1876 24282180 SGTC_691 1548-0686 185 µM 0.291828480469563 0.38757761595466 no 1280 0.385208884173252 1734 46495133 SGTC_1642 st009582 77.7 µM 0.288553754098408 0.388816511863195 no 1281 0.386461444765845 1926 6739311 SGTC_672 1441-0018 53.7 µM 0.287254285155708 0.389308441836334 no 1282 0.386958811671448 1755 251141 SGTC_2967 9089538 49.85 µM 0.286941834970076 0.389426750195514 no 1283 0.387078428539107 1968 728216 SGTC_2207 7258803 200 µM 0.286693143792053 0.389520923716919 no 1284 0.387173643892711 1872 3666799 SGTC_2331 7980721 200 µM 0.286664929786268 0.389531608109636 no 1285 0.387184446500267 1875 2981221 SGTC_1138 3761-0006 1.03 µM 0.286155971601584 0.3897243603728 no 1286 0.387379331929799 1840 12061087 SGTC_3126 9127922 49.47 µM 0.284638437808688 0.390299240481882 no 1287 0.387960579855326 1844 45595682 SGTC_1441 4106-0040 13 µM 0.284357894259264 0.390405543777998 no 1288 0.388068061579977 1817 2904180 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.284355822769097 0.390406328735574 no 1289 0.388068855240304 1881 6708630 An antioxidant. SGTC_2493 resveratrol 26.09 µM 0.283003520866612 0.390918856789035 no 1290 0.38858706901571 1765 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.282806719525437 0.390993461136135 no 1291 0.388662501545482 1826 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1631 benzylvanillin 81.9 µM 0.281754317011734 0.391392478687288 no 1292 0.389065951001728 1822 75506 SGTC_314 1671-0008 2.74 µM 0.280891187122781 0.391719819024916 no 1293 0.389396930151309 1840 3913060 SGTC_2375 9072683 200 µM 0.280407854362834 0.391903155542688 no 1294 0.389582305881883 1968 16798029 SGTC_1411 3909-8223 150 µM 0.27936007240528 0.392300679828746 no 1295 0.389984254673159 1913 X1411 SGTC_1941 st076221 61.8 µM 0.278678293286593 0.392559404500078 no 1296 0.390245861137283 1938 2828568 SGTC_2130 NSC 7 2.4545 µM 0.274057555607851 0.394314149375692 no 1297 0.392020195584592 1929 21448 SGTC_395 anisomycin 6.25 µM 0.272754626889505 0.394809331741208 no 1298 0.39252091997252 1812 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1439 4092-1168 46 µM 0.271613645441417 0.395243105146832 no 1299 0.392959553118328 1853 2886240 SGTC_1498 4478-3555 97.6 µM 0.271164308130581 0.395413967932898 no 1300 0.39313233142794 1950 3437919 SGTC_2793 7325131 81.82 µM 0.270207769474782 0.395777763518123 no 1301 0.393500207885086 1853 4176441 SGTC_1195 1502-0147 41.1 µM 0.269418518104183 0.396078003957272 no 1302 0.393803818722266 1808 817940 SGTC_1659 st012954 42.1 µM 0.26807748432097 0.39658829016797 no 1303 0.394319838311666 1896 24207262 SGTC_2597 laccaic acid a 100 µM 0.268076752413201 0.396588568719802 no 1304 0.394320119994941 1826 5491415 A textile dye. SGTC_2448 5185112 27.17 µM 0.266596766667656 0.397151934259455 no 1305 0.394889822694978 1829 5718189 SGTC_653 0203-0016 55.2 µM 0.266404058320106 0.397225305679513 no 1306 0.394964020021869 1860 295302 SGTC_1764 st044502 93.5 µM 0.264367653767542 0.398000864401005 no 1307 0.395748316835486 1838 8407 SGTC_1797 st048695 56.8 µM 0.263234009971303 0.398432784235682 no 1308 0.396185109355514 1940 592262 YIL048W NEO1 SGTC_1608 st001473 40.5 µM 0.262023736692702 0.398894037358232 no 1309 0.396651571052915 1773 7292267 SGTC_3331 9141060 1.957 µM 0.261584208133129 0.399061583213225 no 1310 0.396821010140387 1790 4906567 YPR165W RHO1 SGTC_665 3914-0008 307 µM 0.260911284073383 0.399318134165706 no 1311 0.397080461369104 1801 1069549 SGTC_975 1335-0046 28.5 µM 0.259929318079244 0.399692584741763 no 1312 0.397459147890047 1756 16486740 SGTC_2861 9024595 19.48 µM 0.259841654810932 0.399726017642673 no 1313 0.397492959161158 1967 16482810 SGTC_2246 7293507 91.5585 µM 0.258988933255193 0.400051265778847 no 1314 0.397821889619621 1989 887656 SGTC_2680 butyl paraben 22.24 µM 0.258271642644122 0.400324911064085 no 1315 0.398098634952566 1923 7184 An antifungal and steroid mimetic. SGTC_350 k064-0020 19.8 µM 0.257836360583719 0.400490994381702 no 1316 0.398266600647415 1987 2790705 SGTC_3288 9119690 36.221 µM 0.255929030574918 0.401218954272263 no 1317 0.399002818895495 1788 17595618 YKL019W RAM2 SGTC_873 0591-4978 488 µM 0.255370539710547 0.401432175373843 no 1318 0.399218461258638 2019 3305145 SGTC_943 3253-1379 105 µM 0.255123900386649 0.401526346885259 no 1319 0.399313702488523 1926 668464 SGTC_950 1165-0508 94.1 µM 0.25319776474342 0.402261977870022 no 1320 0.400057696864103 1807 6148369 SGTC_1720 st037298 9.481 µM 0.252774419137317 0.402423708812523 no 1321 0.400221268226048 1825 597396 SGTC_2204 7233102 200 µM 0.252400865142673 0.402566431712944 no 1322 0.400365615751168 1918 2172480 SGTC_1461 k072-0203 53.8 µM 0.252158556562347 0.402659016930659 no 1323 0.400459255127043 1901 5418714 SGTC_2266 7929956 200 µM 0.251536547934881 0.402896709123765 no 1324 0.40069965455427 1811 2967153 SGTC_310 1273-0058 1.06 µM 0.247773901778014 0.404335315732259 no 1325 0.402154674374987 1928 2734232 SGTC_2588 indole-3-carbinol 100 µM 0.247173713206132 0.404564911484148 no 1326 0.402386894027614 1988 3712 Induces cell cycle arrest. SGTC_1761 st044296 37 µM 0.246936129527256 0.404655805676842 no 1327 0.402478827325492 1846 1826700 SGTC_356 1634-0012 32.5 µM 0.244795634940743 0.405474942384585 no 1328 0.40330733696187 2033 735457 SGTC_337 1315-0038 354 µM 0.24404623468568 0.405761825227934 no 1329 0.403597506067189 1874 1626437 SGTC_2321 7390090 138.78 µM 0.243493972178286 0.405973272879733 no 1330 0.403811377063717 1799 649046 SGTC_3276 9139060 49.47 µM 0.24316186732826 0.406100440823234 no 1331 0.403940002933539 1895 4870619 SGTC_2697 mebhydrolin 72.4 µM 0.243103165618288 0.406122919621871 no 1332 0.403962739480167 1975 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2173 5763948 167 µM 0.243041945861255 0.406146362992485 no 1333 0.403986451671017 1970 2867177 SGTC_4 0960-0234 25.671 µM 0.24265296903136 0.40629532485536 no 1334 0.404137121939337 1858 6821112 SGTC_2427 5545055 42.75 µM 0.242542083738431 0.406337791771871 no 1335 0.404180075990054 1879 5372858 SGTC_3204 9114183 49.47 µM 0.242168651601604 0.406480817137925 no 1336 0.404324742287329 1801 17027248 SGTC_910 3454-3003 490 µM 0.241798013175639 0.406622784844479 no 1337 0.40446833924771 2016 820824 SGTC_1850 st056238 17 µM 0.240839126314102 0.406990129543664 no 1338 0.404839901788673 1982 5393177 SGTC_371 0195-0006 7.36 µM 0.239285930854936 0.407585324364916 no 1339 0.40544193706225 1827 3928593 SGTC_3336 9143619 71.43 µM 0.239276397268573 0.407588978358877 no 1340 0.405445633075355 1978 45595730 SGTC_473 2-arachidonoylglycerol 10 µM 0.239094882849063 0.407658549996074 no 1341 0.405516004809378 1821 5282280 An endocannabinoid. SGTC_3171 9103192 49.47 µM 0.238822530241343 0.407762943952199 no 1342 0.405621599533687 2030 13018434 SGTC_2312 7706453 155.7 µM 0.2386257263444 0.407838383830887 no 1343 0.40569790729442 1861 976098 SGTC_1314 1222-0010 41.1 µM 0.238366675059765 0.407937689906276 no 1344 0.4057983560093 1897 3526027 SGTC_1961 st076550 68.7 µM 0.236805386438893 0.408536327484519 no 1345 0.406403886312455 1899 1579337 SGTC_1047 2043-3044 82 µM 0.236677512514372 0.408585367061337 no 1346 0.406453490885256 1841 669592 SGTC_2985 9022375 71.43 µM 0.234556303936014 0.409399057587999 no 1347 0.407276563900681 1899 4939335 SGTC_1741 st038134 10.228 µM 0.23432565632341 0.409487557058787 no 1348 0.407366084721882 1969 1272587 SGTC_1932 st074806 40.9 µM 0.234280764306347 0.409504782658586 no 1349 0.407383509138122 1948 17251235 SGTC_809 3998-0021 90 µM 0.23366439372641 0.409741309019013 no 1350 0.407622766126977 2018 715485 SGTC_1202 1988-0068 29.6 µM 0.233046064589703 0.409978619965078 no 1351 0.407862817995682 1813 2850480 SGTC_2765 myclobutanil 7.74 µM 0.231153874235502 0.410705035572051 no 1352 0.408597631316994 1898 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_519 k048-0011 62.8 µM 0.230778600286303 0.41084914046813 no 1353 0.408743403505489 1915 6836379 SGTC_2939 9044578 71.43 µM 0.229243154070102 0.41143887572622 no 1354 0.409339966703707 1867 2653634 SGTC_3261 9137475 49.47 µM 0.228722648021062 0.411638837546047 no 1355 0.409542245389899 1979 17027690 SGTC_89 0302-0250 142.109 µM 0.228157220075548 0.411856082932228 no 1356 0.409762008879887 2013 4203518 YLR208W SEC13 SGTC_1299 1079-1439 3.74 µM 0.228087375868792 0.411882919937149 no 1357 0.409789157024865 1873 323161 SGTC_2505 galangin 7.89 µM 0.225763346536483 0.41277614147542 no 1358 0.410692743153205 1830 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2213 7173844 200 µM 0.222299025421815 0.414108462228613 no 1359 0.412040555363112 1909 892728 SGTC_3167 9103034 49.47 µM 0.2203189074988 0.414870428164775 no 1360 0.412811397931381 1957 5127859 SGTC_1245 0418-0076 17.2 µM 0.220212114398039 0.41491153217392 no 1361 0.412852981135704 1926 6790114 SGTC_2157 5649910 96.377 µM 0.21992045650276 0.41502379425274 no 1362 0.412966552159591 1855 2858091 SGTC_3139 9095020 49.47 µM 0.219618119709775 0.415140174072152 no 1363 0.413084289215436 2009 25236292 SGTC_2417 cerulenin 830 nM 0.219242656305723 0.415284713201628 no 1364 0.413230514374747 2035 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3316 9136639 10.545 µM 0.218844129603505 0.415438143366785 no 1365 0.413385734761847 1966 4903665 SGTC_2735 sertaconazole 140 nM 0.218510142810637 0.415566736022682 no 1366 0.413515828215612 2021 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2128 5255449 168.493 µM 0.217524038283692 0.415946461834919 no 1367 0.413899987804534 1912 736008 SGTC_2746 daunorubicin 9.88 µM 0.216279749263909 0.416425720422758 no 1368 0.414384846629921 2031 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_692 k241-0027 77.8 µM 0.215493989758787 0.416728432813894 no 1369 0.414691098737748 2006 3600480 SGTC_1278 0874-0585 172 µM 0.214858830647038 0.416973162785683 no 1370 0.414938691805884 1964 766306 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.213767996378621 0.417393541699487 no 1371 0.415363991620437 1870 2374 Ca(2+)-ATPase inhibitor. SGTC_3114 9122766 49.47 µM 0.21306466842625 0.417664635949029 no 1372 0.415638261194253 1880 17176985 SGTC_2012 4023501 200 µM 0.212326169863065 0.417949328652748 no 1373 0.415926290125503 1892 3477460 SGTC_2821 7996764 71.43 µM 0.212186486750931 0.418003181618117 no 1374 0.415980774364322 1936 2987135 SGTC_1946 st076057 65.1 µM 0.210352560528535 0.418710369708532 no 1375 0.416696257730867 1925 953009 SGTC_1444 4112-3581 28 µM 0.209571102785422 0.419011790931692 no 1376 0.417001217704494 1945 2877249 SGTC_205 1486-1330 71.903 µM 0.209350529293844 0.419096878400232 no 1377 0.417087304452243 1946 4118834 SGTC_844 0330-0132 15.3 µM 0.208866859997236 0.419283469800503 no 1378 0.417276087721978 2028 2828079 SGTC_730 1436-0052 41.2 µM 0.20869140906893 0.419351160278168 no 1379 0.417344573526811 1997 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1259 0671-0132 43 µM 0.206584900640961 0.420164055161328 no 1380 0.418167026717946 1899 X1259 SGTC_2826 7992541 19.48 µM 0.205902612712799 0.420427421106473 no 1381 0.418433492264879 2032 2985066 SGTC_2433 5607874 27.82 µM 0.205373333587321 0.420631749569531 no 1382 0.41864022646437 1921 2252428 SGTC_2396 5342950 42.78 µM 0.205245301124657 0.420681179778247 no 1383 0.418690238783344 1917 1886677 SGTC_594 1487-1584 10.8 µM 0.202112351391793 0.421891123088766 no 1384 0.419914446055911 1874 5013332 SGTC_3260 9137109 49.47 µM 0.20180928523727 0.422008206369061 no 1385 0.420032911166344 2058 17478346 SGTC_3211 9128781 49.47 µM 0.20159019655599 0.422092850999725 no 1386 0.420118554951169 1823 17194361 SGTC_854 0422-0053 192 µM 0.201575129458097 0.422098672285946 no 1387 0.420124444957666 2029 3596728 SGTC_970 1315-0089 19.5 µM 0.201080022081398 0.422289970193414 no 1388 0.420318001508527 2005 6811083 YLR033W RSC58 SGTC_1887 st057648 70.8 µM 0.200379040224748 0.422560844526237 no 1389 0.420592075271862 2070 688672 SGTC_1092 toremifene 6.32 µM 0.199943522405597 0.422729156350039 no 1390 0.420762375836282 2078 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2847 9005661 71.43 µM 0.197720338629335 0.423588555334032 no 1391 0.421631937962396 2076 2991449 SGTC_219 mitoxanthrone 164.414 µM 0.197634910047592 0.423621586081576 no 1392 0.421665359614968 2029 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_629 3448-6466 76.7 µM 0.196883911425868 0.423911980893121 no 1393 0.421959192040354 1972 573744 SGTC_141 0443-0274 32.331 µM 0.195955778632392 0.424270926706759 no 1394 0.422322389217126 2089 1627241 SGTC_3071 9117417 49.47 µM 0.195727572574458 0.424359192686735 no 1395 0.422411701003678 2075 45595590 YGL055W OLE1 SGTC_3324 9138759 60.749 µM 0.195512461605264 0.424442397196528 no 1396 0.42249589148784 1992 45595710 SGTC_2831 7999036 19.48 µM 0.19529969488114 0.424524698269244 no 1397 0.422579167960724 2070 2988270 SGTC_3230 9131665 49.47 µM 0.195206490258317 0.424560752126125 no 1398 0.422615649155016 1997 15943720 SGTC_794 k038-0031 316 µM 0.194923593634912 0.424670187411813 no 1399 0.422726381703515 1984 6624242 SGTC_2560 caryophyllene 100 µM 0.191930942468004 0.425828213896471 no 1400 0.42389814971133 2045 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_288 1315-0019 35.1 µM 0.191255911318497 0.426089510553831 no 1401 0.424162550546079 1975 6811474 SGTC_2913 7966556 36.57 µM 0.187627678511679 0.427494510201845 no 1402 0.425584263628831 2058 2976516 SGTC_1054 3429-0080 167 µM 0.187257170490259 0.427638038084143 no 1403 0.425729500967802 2039 1162877 SGTC_1878 temozolomide 1 mM 0.186711999649647 0.427849244485451 no 1404 0.425943223597597 2109 5394 DNA alkylating agent. SGTC_398 bronopol 33.3 µM 0.186251087500781 0.428027824085294 no 1405 0.426123931374368 1984 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_557 1315-0110 16.2 µM 0.185967875255457 0.428137561485291 no 1406 0.426234976837371 1993 6833801 SGTC_3013 9080133 71.4286 µM 0.184977625647205 0.42852130116223 no 1407 0.42662329243217 2029 17050193 SGTC_3273 9137859 49.47 µM 0.184509343136467 0.428702792686788 no 1408 0.426806949113002 2121 2377234 SGTC_2902 5787006 60.46 µM 0.183910795271325 0.428934792900028 no 1409 0.427041717930486 1952 591003 SGTC_825 1988-2224 89.6 µM 0.181881380336644 0.429721586810038 no 1410 0.427837908552799 1975 1180859 SGTC_1656 st012921 11 µM 0.181340667165879 0.429931265807758 no 1411 0.428050093678457 2049 6732821 SGTC_208 k072-0098 12.366 µM 0.181295450730301 0.429948800837479 no 1412 0.428067838327129 2106 5948901 SGTC_2164 5685496 200 µM 0.180574193691691 0.430228524506255 no 1413 0.428350906657214 2070 759046 SGTC_959 1222-0044 107 µM 0.180080626339047 0.430419963931682 no 1414 0.42854463595234 2133 6083612 SGTC_2561 acetosyringone 100 µM 0.179504249802696 0.430643543162375 no 1415 0.428770890334051 2129 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3188 9110789 49.47 µM 0.178994503410105 0.430841294768824 no 1416 0.428971008819709 2084 849217 SGTC_2041 5107442 45.335 µM 0.178454111235856 0.43105095407109 no 1417 0.429183178299989 2075 793005 SGTC_2299 7976368 114.88 µM 0.178328774632135 0.431099584468537 no 1418 0.429232391046266 2075 2979718 SGTC_2124 5246320 200 µM 0.178228090913174 0.431138650343613 no 1419 0.429271924766107 1997 579342 SGTC_535 2293-4129 48.2 µM 0.176802314658637 0.43169193205841 no 1420 0.429831835431861 2091 396118 YIL048W NEO1 SGTC_3141 9094609 49.47 µM 0.17608249231253 0.43197131476762 no 1421 0.430114567565468 1872 25236309 YDL196W YDL196W SGTC_3201 9113999 49.47 µM 0.174483390863637 0.432592091267667 no 1422 0.430742791360655 2039 16649224 SGTC_2192 5915882 198.485 µM 0.174219694138461 0.43269447523828 no 1423 0.430846404267792 2063 2876149 SGTC_1794 st048918 76.9 µM 0.17406916819392 0.432752921084473 no 1424 0.430905551735772 2098 672303 SGTC_1142 3253-1408 9.78 µM 0.172691041903205 0.433288084831036 no 1425 0.431447142763287 2120 256655 SGTC_2983 9022671 12.99 µM 0.171804531658722 0.433632405488034 no 1426 0.43179560137661 2139 6405161 SGTC_2308 7584454 197.62 µM 0.171594574564086 0.433713960229622 no 1427 0.431878136529261 2079 893577 SGTC_2285 7945142 200 µM 0.171473728436688 0.433760902408099 no 1428 0.431925643076852 1989 2970608 SGTC_1137 ixabepilone 100 µM 0.171251614383467 0.433847184129858 no 1429 0.432012962234545 1948 154225 A novel microtubule stabilizer. SGTC_871 0574-0004 149 µM 0.170059925012027 0.434310157734037 no 1430 0.432481504790819 1974 9551173 SGTC_3209 9113616 49.47 µM 0.168926269665175 0.434750668656229 no 1431 0.432927317964387 2172 16649353 SGTC_2720 fluspirilene 36.88 µM 0.168580182450676 0.43488516590469 no 1432 0.433063434778534 2076 3396 An atypical antipsychotic. SGTC_1711 st032263 62.8 µM 0.167732959556404 0.435214447480138 no 1433 0.433396682772331 2041 3958979 SGTC_918 glabranin 770.725 nM 0.167411553053066 0.435339377071511 no 1434 0.433523117718906 2031 124049 Also referred to as licorice root. SGTC_174 3553-0389 74.3 µM 0.166856760934131 0.435555038019728 no 1435 0.433741377939683 2049 738071 SGTC_2253 7938677 135.83 µM 0.163954873259674 0.436683381957116 no 1436 0.434883334452676 2142 2301972 SGTC_1112 tnp00069 1.16933 µM 0.161816058007475 0.43751535009147 no 1437 0.435725353620007 2108 145826 SGTC_1574 spiramycin 23.7 µM 0.160949638267116 0.437852453667504 no 1438 0.436066533110631 2095 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2273 7815444 169.05 µM 0.160523840784053 0.438018138016551 no 1439 0.436234221452911 2153 2824616 SGTC_2811 7967822 32.47 µM 0.159969875518079 0.43823371068144 no 1440 0.436452402217497 2064 2232244 SGTC_2885 9057732 51.95 µM 0.159945414360448 0.438243230035081 no 1441 0.436462036758857 2028 6471414 SGTC_2517 totarol 10 µM 0.159486744385651 0.43842173358229 no 1442 0.436642700548389 1959 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2759 disulfiram 3.38 µM 0.156278555077538 0.439670633546414 no 1443 0.437906729604145 2039 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1693 xanthone 101.9 µM 0.154864717429348 0.440221210744002 no 1444 0.438463984713434 2074 7020 An insecticide. SGTC_1819 st053448 58.6 µM 0.154594859763213 0.440326311990958 no 1445 0.438570361296384 2046 2857616 SGTC_2477 5967686 25.23 µM 0.154454589880335 0.440380944449995 no 1446 0.438625656757211 2024 776118 SGTC_182 3448-4371 550.524 µM 0.153979481522218 0.440565998571215 no 1447 0.438812957000979 2192 3491403 SGTC_2646 retinol 96.75 µM 0.153956580081515 0.440574918982469 no 1448 0.438821985699339 2090 445354 A vitamin A analog and teratogen. SGTC_2761 levamisole 97.89 µM 0.153767220189175 0.440648678297054 no 1449 0.438896640446921 2141 26879 An alkaline phosphatase inhibitor. SGTC_2317 5986382 200 µM 0.153244187850791 0.440852420128814 no 1450 0.439102856155448 2090 877883 SGTC_676 falcarinol 140 µM 0.152070375574973 0.441309723466359 no 1451 0.439565714647266 2145 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_99 0109-0120 622.8 µM 0.151000446206988 0.441726623448067 no 1452 0.43998768195612 2117 759414 SGTC_202 3594-0513 34.79 µM 0.150707916762906 0.441840619352586 no 1453 0.440103063948471 2136 708429 SGTC_1082 camptothecin 424.86 nM 0.149598684360958 0.442272920212709 no 1454 0.440540623115318 1963 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1205 4161-2785 76 µM 0.148859022868167 0.442561226538009 no 1455 0.440832437945674 1937 3498106 SGTC_3306 9127676 59.7925 µM 0.14878496477109 0.442590094688024 no 1456 0.440861657476642 2003 41905287 SGTC_1010 4112-3296 15.2 µM 0.148420638809702 0.442732114877583 no 1457 0.441005406520794 2166 704384 SGTC_731 3966-0296 387 µM 0.147716794575181 0.443006505641566 no 1458 0.441283138445287 2090 660956 SGTC_977 1348-1378 135 µM 0.144829860130049 0.444132249698782 no 1459 0.442422602902118 2143 X977 SGTC_992 3909-8734 162 µM 0.144436596833649 0.444285635634423 no 1460 0.442577859843069 2023 4288319 SGTC_2238 6671620 73.2395 µM 0.144283083501295 0.444345513272104 no 1461 0.442638467970681 2187 729941 SGTC_1926 methyl fluorone black 53.6 µM 0.143591216352461 0.444615390726166 no 1462 0.442911638555109 2096 72721 Reacts with homocysteine. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.143534518945675 0.444637507892108 no 1463 0.442934025652693 2153 165521 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.142574756420909 0.445011929017885 no 1464 0.443313017615424 2065 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_470 aa-861 153 µM 0.141721730894599 0.445344751257542 no 1465 0.443649904711548 2012 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3179 9107801 49.47 µM 0.141458264343538 0.445447554956569 no 1466 0.44375396433312 2083 4818259 SGTC_1088 bifonazole 369 nM 0.141039633373499 0.445610910795297 no 1467 0.443919316181663 2138 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_390 dec-rvkr-cmk 16.7 µM 0.140941490699019 0.445649208818715 no 1468 0.443958082220634 2081 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_687 k029-0044 34.9 µM 0.140305348415089 0.445897461656818 no 1469 0.444209369351348 2174 5829338 SGTC_2947 9072639 7.68 µM 0.140050233676884 0.445997025470848 no 1470 0.444310150362382 2058 16488146 SGTC_622 1348-1566 26.3 µM 0.139104561481453 0.446366123302967 no 1471 0.44468376186626 2106 7340407 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.139065812953206 0.446381247927752 no 1472 0.444699071494029 2086 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1914 st062367 72.6 µM 0.137977636707108 0.446806025058858 no 1473 0.445129045901528 2058 978205 SGTC_1609 st001574 46.4 µM 0.137416461891414 0.447025107418953 no 1474 0.445350809886733 2110 3960012 SGTC_495 decylubiquinone 155 µM 0.135354387935391 0.447830278378042 no 1475 0.446165842664823 2020 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_835 0312-0010 67.2 µM 0.134445020465827 0.448185424493642 no 1476 0.446525341787695 2070 1626196 SGTC_1086 cerivastatin 2.18 µM 0.134425751483799 0.448192950289201 no 1477 0.446532959847242 2186 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_589 1227-0070 34.1 µM 0.134136100877418 0.448306080007598 no 1478 0.446647476605295 2089 2841384 SGTC_33 0986-0033 35.816 µM 0.133913272124159 0.448393113773217 no 1479 0.446735577590027 2172 2848082 SGTC_650 1328-0195 38 µM 0.133663041257687 0.448490853378198 no 1480 0.446834515826993 2188 2780821 SGTC_2526 patulin 37.61 µM 0.133485336272067 0.448560266438713 no 1481 0.446904780223852 2088 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1785 bathophenanthroline 24 µM 0.133393194058168 0.448596258581753 no 1482 0.446941213831455 2004 72812 An iron chelator. SGTC_1847 st056231 15 µM 0.133078623406791 0.448719137824235 no 1483 0.447065600406475 2177 5393180 SGTC_19 0279-0214 38.434 µM 0.132903639561162 0.448787493064547 no 1484 0.447134794243892 2170 3566274 YBR002C RER2 SGTC_1988 st071872 53.4 µM 0.132894449615113 0.448791083043517 no 1485 0.447138428267456 2188 16414116 SGTC_341 1486-1430 230 µM 0.132515013824904 0.448939310259099 no 1486 0.447288474216591 2118 2054753 YPL210C SRP72 SGTC_1250 0485-0349 40.2 µM 0.132206698284232 0.449059759481608 no 1487 0.447410401582502 2078 6842794 YDL195W SEC31 SGTC_402 epigallocatechin gallate 10 µM 0.132169810269208 0.449074170788077 no 1488 0.447424989757978 2027 65064 An antioxidant. SGTC_1792 st045773 43.6 µM 0.13191120041269 0.449175205648523 no 1489 0.447527264700013 2052 2919270 SGTC_2086 5274770 176.623 µM 0.131808640220565 0.449215275238108 no 1490 0.447567826138063 2061 689278 SGTC_1130 3454-2858 15.9 µM 0.131516923865754 0.449329249721237 no 1491 0.447683199773062 1986 715628 YIL048W NEO1 SGTC_3283 9109332 35.8195 µM 0.131250339669351 0.449433408648554 no 1492 0.447788637526313 2170 17027281 SGTC_11 0438-0307 1.3 µM 0.131196949417835 0.449454269536438 no 1493 0.44780975455618 2192 4011476 SGTC_2683 piperine 63.03 µM 0.130708854429993 0.449644986754067 no 1494 0.448002813810678 2090 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2950 9072895 21.46 µM 0.129771820525934 0.45001115399147 no 1495 0.448373479156716 2034 17332245 SGTC_3016 9080866 49.47 µM 0.129425136528553 0.450146639424851 no 1496 0.448510629438742 2142 17066299 SGTC_1181 1222-0449 220 µM 0.125670886173597 0.451614183716458 no 1497 0.449996224293454 2147 658318 SGTC_1899 st063254 59.6 µM 0.125244235855517 0.451781004449001 no 1498 0.450165098890477 2026 3093813 SGTC_1140 3229-1848 2.98 µM 0.123879926961357 0.452314507695361 no 1499 0.450705173237169 2171 2849525 SGTC_1297 1068-0111 14.1 µM 0.122881750772793 0.452704891965942 no 1500 0.45110036843422 2102 767057 SGTC_1994 st072947 40.9 µM 0.122352275522981 0.452911987025901 no 1501 0.451310016534192 2103 5286565 YDL195W SEC31 SGTC_3223 9129970 49.47 µM 0.121641597635734 0.453189976478661 no 1502 0.451591433970394 2144 17248386 SGTC_1443 4112-3303 14 µM 0.121001744576818 0.453440281652254 no 1503 0.451844826688469 2144 704433 SGTC_2470 5664817 21.68 µM 0.120075507618461 0.453802650559421 no 1504 0.452211667041425 2225 2859561 SGTC_1509 1326-1131 80 µM 0.1200230141208 0.45382318858758 no 1505 0.452232458554163 2191 768313 SGTC_1349 flufenamic acid 69 µM 0.119760772005115 0.453925792399862 no 1506 0.452336328813467 2146 3371 A non-steroidal anti-inflammatory. SGTC_1756 st041558 35.5 µM 0.118081102325583 0.454583045945548 no 1507 0.453001698422955 2235 3955792 SGTC_2529 gangaleoidin 93.61 µM 0.117793568812719 0.454695570120482 no 1508 0.453115612707516 2134 4565183 SGTC_2332 7982454 138.89 µM 0.117433477050669 0.454836494571492 no 1509 0.45325827837234 2184 2981748 SGTC_2650 prasterone 100 µM 0.116821164545648 0.455076140430993 no 1510 0.453500885852188 2186 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2853 9015042 58.44 µM 0.116699790515725 0.455123645543277 no 1511 0.453548978143276 2149 6457456 SGTC_1311 1190-0148 100 µM 0.116248468666767 0.455300295999585 no 1512 0.453727812333693 2190 1961333 SGTC_671 0560-0003 407 µM 0.115117203373303 0.455743119733957 no 1513 0.454176112117503 2158 3238678 SGTC_1145 3546-0597 10.2 µM 0.114237971760548 0.456087325129629 no 1514 0.454524575906394 2110 875334 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.113669349393651 0.45630994944011 no 1515 0.454749955321268 2197 2346 DNA damaging agent; causes G2/M arrest. SGTC_3053 9095903 49.47 µM 0.113635039032331 0.456323382908199 no 1516 0.454763555058128 2222 17174018 SGTC_1393 3470-5649 58.2 µM 0.109492658143424 0.457945603511247 no 1517 0.456405872356037 2130 4108395 SGTC_3221 9128209 49.47 µM 0.109311537894132 0.458016549197114 no 1518 0.456477697759871 2116 16460723 SGTC_1524 corynanthine 62.1 µM 0.109160522310269 0.458075703761267 no 1519 0.456537585885363 2117 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_591 4299-0174 154 µM 0.108082105336141 0.458498159173914 no 1520 0.456965281432561 2152 5509088 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.107539003116942 0.458710929977489 no 1521 0.457180692350027 2194 66535 A nucleotide analog. SGTC_753 1322-0200 289 µM 0.103480917613545 0.460301133796699 no 1522 0.458790646859977 2147 5403907 SGTC_701 4424-0219 185 µM 0.103407509744948 0.460329905373431 no 1523 0.458819776093123 2235 2911779 SGTC_3027 9089541 49.47 µM 0.10249833247558 0.460686266679806 no 1524 0.459180568185742 2144 9943819 SGTC_3099 9120367 49.47 µM 0.101501321009547 0.461077091784838 no 1525 0.459576254481116 2227 24824940 SGTC_1986 st071812 45 µM 0.101315983150535 0.461149747750831 no 1526 0.459649814380537 2225 11838594 SGTC_2898 9056270 58.44 µM 0.100922866486049 0.461303861250194 no 1527 0.459805845475707 2182 19154699 SGTC_1303 1160-0052 261 µM 0.100847232343516 0.46133351276528 no 1528 0.459835865972416 2236 3562476 SGTC_2482 5981709 142.65 µM 0.100185871214391 0.461592801098534 no 1529 0.460098381357035 2171 877755 SGTC_2838 9002687 71.43 µM 0.099771292079958 0.461755346247051 no 1530 0.460262949951852 2089 6457060 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0994620932826019 0.461876578805782 no 1531 0.460385691897337 2251 1241132 A phosphatase inhibitor. SGTC_965 1291-5240 308 µM 0.0987751180363106 0.46214594493053 no 1532 0.460658412396545 2203 2834598 SGTC_1930 st074634 34.3 µM 0.0983058170974443 0.462329969956897 no 1533 0.460844729591262 2232 684253 YOR116C RPO31 SGTC_1351 1496-0003 46.5 µM 0.0964585566143158 0.463054406497805 no 1534 0.461578193712154 2220 3891978 SGTC_2719 novobiocin 32.65 µM 0.0961341224371461 0.463181651935707 no 1535 0.461707025507523 2214 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2356 9061756 188.97 µM 0.0961131361894144 0.463189883024173 no 1536 0.461715359219264 2225 20104043 SGTC_2001 4023502 57.655 µM 0.0956223470280615 0.463382381616951 no 1537 0.461910258082485 2168 108941 YCR052W RSC6 SGTC_425 3825-7017 13.1 µM 0.0933776123094965 0.464262925875526 no 1538 0.462801787793182 2176 3397440 SGTC_1732 st034308 51.822 µM 0.0926890590971306 0.464533060595904 no 1539 0.463075294583489 2030 830119 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0922938718069918 0.464688108740536 no 1540 0.463232278589801 2240 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_268 camptothecin 39.6153 µM 0.0918458609620646 0.464863888210871 no 1541 0.463410253122957 2259 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_693 4161-2696 114 µM 0.0917939639209311 0.464884250738562 no 1542 0.463430869954269 2198 805759 SGTC_2351 9026858 72.31 µM 0.0915962722939969 0.464961818646708 no 1543 0.463509406639604 2217 1409300 SGTC_320 4092-0846 5.34 µM 0.0909295873436273 0.465223414420994 no 1544 0.463774270135463 2226 1359356 SGTC_646 4092-0839 27.3 µM 0.0905870549758978 0.465357824116769 no 1545 0.463910359135409 2217 877796 SGTC_2737 bleomycin 30.5 nM 0.0905340876573569 0.465378608844958 no 1546 0.463931403566107 2221 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2872 9044037 25.97 µM 0.0903122383276556 0.465465665023508 no 1547 0.464019547557843 2165 6465195 SGTC_1947 st076332 61.6 µM 0.0899641722991431 0.465602253387034 no 1548 0.464157842852123 2246 24208416 SGTC_1997 st073024 93.8 µM 0.0894543674469788 0.465802318745661 no 1549 0.464360408817648 2264 686268 SGTC_1000 4048-0884 8.67 µM 0.0894135771694059 0.465818326659667 no 1550 0.464376616834825 2170 13040088 SGTC_1337 1486-1011 40.3 µM 0.0886930208354147 0.466101114016483 no 1551 0.464662939621758 2264 X1337 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0875733223333014 0.466540581411925 no 1552 0.46510790319481 2248 77254 SGTC_407 eburnamonine 100 µM 0.0845051112431083 0.467745022651527 no 1553 0.466327419597619 2199 3195 SGTC_2594 a-mangostin 100 µM 0.0837400089948593 0.468045413710845 no 1554 0.466631573132467 2231 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2036 5160441 105 µM 0.0830108255239517 0.468331719435866 no 1555 0.466921465900677 2183 134534 YIL048W NEO1 SGTC_2895 9054447 58.44 µM 0.0814449522141261 0.468946597222786 no 1556 0.467544050564512 2198 2697450 SGTC_1559 coumarin 343 70.1 µM 0.0795652660279336 0.469684798879878 no 1557 0.468291510648048 2235 108770 A hepatotoxic, DNA x-linker. SGTC_540 1187-0821 17.3 µM 0.0765079974121495 0.470885689255586 no 1558 0.469507475805714 2127 847520 SGTC_3138 9097216 49.47 µM 0.0755144587019907 0.47127600726056 no 1559 0.469902697001368 2310 25237486 SGTC_1798 st045719 60.953 µM 0.0745640170197614 0.471649420152327 no 1560 0.470280802325081 2271 3980186 SGTC_3025 9087895 49.47 µM 0.0744393159986722 0.471698414987409 no 1561 0.470330412961666 2279 17173641 SGTC_2580 diallyl disulphide 81.36 µM 0.0738209227840363 0.471941387022938 no 1562 0.470576439236478 2219 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2788 5282734 71.43 µM 0.0734941837500598 0.472069769833824 no 1563 0.470706436127615 2239 743706 SGTC_1857 st056007 79.3 µM 0.0729902096578356 0.472267797805726 no 1564 0.470906954145809 2276 619834 SGTC_1096 rimcazole 32.2 µM 0.0724368026248594 0.472485257498667 no 1565 0.47112714872428 2224 18528119 A dopamine reuptake inhibitor. SGTC_1628 st004252 77.7 µM 0.0722402449935292 0.47256249622855 no 1566 0.471205358974168 2254 692968 SGTC_565 1418-0001 44.5 µM 0.072149495363008 0.472598157294546 no 1567 0.471241468612466 2271 2862145 SGTC_2923 7992654 58.14 µM 0.0720541646473813 0.472635618784899 no 1568 0.471279401337344 2218 2985126 SGTC_354 2783-3500 4.88 µM 0.0720010498400039 0.472656491069794 no 1569 0.471300536185009 2187 6740761 SGTC_1806 st050005 60.3 µM 0.0712048307332313 0.472969386647003 no 1570 0.471617368404504 2178 5194765 SGTC_2832 7992762 51.95 µM 0.0709039904736341 0.473087614219153 no 1571 0.471737083716395 2153 2985177 SGTC_2695 st077686 51.995 µM 0.0703450721110327 0.473307270498601 no 1572 0.471959504489501 2212 2876092 SGTC_3339 9145883 14.936 µM 0.0702914788653948 0.473328333202334 no 1573 0.471980832306491 2273 2030670 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0664767124314626 0.474827764172529 no 1574 0.473499148738961 2282 3256 An antibiotic and ribosome inhibitor. SGTC_1527 coumarin 137 µM 0.0662518704693114 0.474916151824515 no 1575 0.473588650394261 2238 323 A hepatotoxic, DNA x-linker. SGTC_3280 9140961 49.47 µM 0.0651859190780549 0.475335204836571 no 1576 0.474012986115618 2231 4901226 SGTC_1468 k284-1086 134 µM 0.0650360219464492 0.475394135467855 no 1577 0.47407265979347 2238 15996457 SGTC_1125 tnp00248 1.32998 µM 0.0646837254704852 0.475532639592814 no 1578 0.474212910438339 2281 24207736 SGTC_123 0083-0120 66.675 µM 0.0646204755194099 0.475557506402971 no 1579 0.474238090837321 2233 16001701 SGTC_1765 st044815 90.4 µM 0.0645132880186804 0.475599647541936 no 1580 0.474280763422014 2176 645695 SGTC_43 0570-0105 72.5 µM 0.0642810542478363 0.475690951992892 no 1581 0.474373219385804 2282 1114046 YDL195W SEC31 SGTC_2436 5633522 8.09 µM 0.0633857468217745 0.476042960734541 no 1582 0.474729668407905 2301 5724242 SGTC_212 3807-4682 38.772 µM 0.0630306468533944 0.476182580868964 no 1583 0.474871050086612 2263 3125501 YBL034C STU1 SGTC_2810 7959871 45.46 µM 0.0629409352819622 0.476217854615303 no 1584 0.474906768903147 2253 2974535 SGTC_2102 5377816 72.7585 µM 0.0628536230469595 0.476252185144076 no 1585 0.474941532613425 2282 1379702 SGTC_1368 1852-0141 284 µM 0.0619185586852498 0.476619856576374 no 1586 0.475313844080603 2232 2838987 SGTC_2018 5133068 143 µM 0.0617949681013161 0.476668454435323 no 1587 0.475363055352307 2296 785362 SGTC_1127 asiatic acid 681.4 nM 0.0606065079477301 0.477135794204571 no 1588 0.475836295230783 2255 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3347 9188721 44.724 µM 0.059163967162404 0.477703088628238 no 1589 0.476410754692226 2225 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3227 9130768 49.47 µM 0.058338412740893 0.478027767039529 no 1590 0.476739535330044 2293 17720899 SGTC_1594 piperine 70.1 µM 0.0559305267276618 0.478974835705996 no 1591 0.477698576036541 2311 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_489 paxilline 115 µM 0.0557937610189069 0.479028631947958 no 1592 0.477753052594679 2200 105008 A toxic potassium channel blocker. SGTC_667 1498-1044 59 µM 0.0541229618735732 0.479685864624973 no 1593 0.478418599063735 2242 6739982 SGTC_3136 9095672 49.47 µM 0.053417959447452 0.479963204059116 no 1594 0.478699448035843 2331 17217380 SGTC_3210 9128157 49.47 µM 0.0522802237373599 0.480410795937924 no 1595 0.479152705467915 2110 17590849 SGTC_1702 st027038 51 µM 0.0522226753778478 0.480433436459942 no 1596 0.479175632622298 2226 5521182 SGTC_1872 amphotericin b 148 nM 0.0511730065198988 0.480846405382513 no 1597 0.479593830665404 2292 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1507 4075-3230 155 µM 0.0503882532252877 0.481155162608105 no 1598 0.479906498532302 2322 659771 SGTC_2412 st077135 33.4 µM 0.04971366099269 0.481420586562315 no 1599 0.480175285011614 2263 13258915 SGTC_903 1134-0042 114 µM 0.0480658140962462 0.482068980096228 no 1600 0.480831895549569 2302 701009 SGTC_1905 st060207 84.5 µM 0.0476358284995515 0.482238178372033 no 1601 0.481003238708095 2211 1948547 SGTC_2961 9083290 32.55 µM 0.0473188407546149 0.482362914321093 no 1602 0.481129556075316 2333 17741490 SGTC_2971 9092186 9.93 µM 0.0466347003206132 0.48263213219402 no 1603 0.481402187624869 2237 25236400 SGTC_2414 st077232 92.9 µM 0.0447450069569729 0.483375791094255 no 1604 0.482155279618914 2235 729801 SGTC_1394 3474-0001 65.7 µM 0.0439714441577991 0.483680231315429 no 1605 0.482463583052156 2278 5017666 YIL048W NEO1 SGTC_420 mitomycin C 81.9 mM 0.0432555437410418 0.483961986645713 no 1606 0.48274891449206 2335 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_722 3534-0461 190 µM 0.0403480979421835 0.485106344437858 no 1607 0.483907804181513 2303 658262 SGTC_1682 st012968 530 nM 0.0399837239733987 0.485249769262582 no 1608 0.48405305115197 2265 24207270 SGTC_728 3030-5151 22.5 µM 0.0395576169393164 0.485417495866059 no 1609 0.484222908876915 2326 3125388 SGTC_3124 9127567 49.47 µM 0.0392502414601667 0.485538488302798 no 1610 0.484345438789853 2339 17592030 SGTC_884 0851-0618 334 µM 0.0391222457698805 0.485588871734109 no 1611 0.484396462492318 2321 9642473 SGTC_1757 st041620 31.8375 µM 0.0390033663069509 0.485635666916186 no 1612 0.484443852366357 2280 5289815 SGTC_2333 9017922 200 µM 0.0373247135779189 0.486296465113285 no 1613 0.485113050316688 2338 3163164 SGTC_603 3794-0023 45.9 µM 0.0369816636411206 0.486431510705729 no 1614 0.485249813016674 2336 3802260 SGTC_1715 st032160 10.2275 µM 0.0369419171426948 0.486447157477404 no 1615 0.485265658747683 2322 5289825 SGTC_1273 0849-0096 14.1 µM 0.0363370260836301 0.486685283965223 no 1616 0.485506813439005 2296 5286025 SGTC_2884 9058502 51.95 µM 0.0353856201503494 0.487059831977806 no 1617 0.485886125494691 2304 6471554 SGTC_2409 alverine citrate 63.97 µM 0.0351010623612914 0.487171858479477 no 1618 0.48599957714694 2292 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3213 9129884 49.47 µM 0.0345386965826544 0.487393257147828 no 1619 0.48622379266679 2317 17190742 SGTC_60 0986-0278 202 µM 0.0338277583399708 0.487673153095409 no 1620 0.486507250327045 2291 3110598 SGTC_2177 5811945 192 µM 0.0333588329951698 0.487857772046115 no 1621 0.486694218944025 2314 5343475 SGTC_2980 9014342 25.29 µM 0.0324451252990136 0.48821751213295 no 1622 0.487058538314718 2276 2996599 SGTC_2611 pyromycin 23.93 µM 0.0320469741222343 0.488374273091925 no 1623 0.487217295092358 2328 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2212 7123476 200 µM 0.031714226733147 0.488505284506212 no 1624 0.487349974650871 2338 1085715 SGTC_2216 7189485 200 µM 0.0316894911239626 0.488515023616983 no 1625 0.487359837773703 2336 731273 SGTC_2657 nystatin 74.44 µM 0.0305694610695184 0.48895601829631 no 1626 0.487806448649118 2330 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3314 9135860 59.4275 µM 0.0301710635215617 0.489112884512368 no 1627 0.487965312992971 2334 25252478 SGTC_2054 5233173 129 µM 0.0300250136568607 0.48917039103651 no 1628 0.488023552073864 2327 6889 SGTC_661 1304-0007 33.6 µM 0.0299494329318809 0.489200150719727 no 1629 0.488053690866681 2336 3117130 SGTC_3030 9087619 49.47 µM 0.0293492452444325 0.489436474938035 no 1630 0.488293025886956 2346 25236973 SGTC_1375 2910-0797 186 µM 0.0289079500653239 0.489610237517974 no 1631 0.48846900251887 2327 742508 SGTC_2648 atorvastatin 78.68 µM 0.0281795722213755 0.489897044888557 no 1632 0.488759464879839 2349 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2099 5377090 177.372 µM 0.0274548501905913 0.490182417924545 no 1633 0.489048475293771 2322 2243829 SGTC_419 nsc-638432 893 µM 0.0271183729894235 0.490314913917286 no 1634 0.489182660311432 2310 368090 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0270552379887822 0.490339774962174 no 1635 0.489207838294382 2348 4330530 SGTC_330 1488-0319 80.1 µM 0.0267447689762967 0.490462030736888 no 1636 0.489331652704931 2291 6846614 SGTC_3003 9075612 71.4286 µM 0.0265612993079752 0.490534277423485 no 1637 0.489404820519446 2327 6501993 SGTC_3065 9113888 49.47 µM 0.0259510694547107 0.490774575958116 no 1638 0.489648183104915 2341 16648368 SGTC_670 4204-0025 119 µM 0.0255924814397031 0.49091578362045 no 1639 0.489791191524713 2336 719039 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0248550720023545 0.491206170176782 no 1640 0.490085281749872 2366 229346 A bile salt which induces apoptosis. SGTC_1052 3253-3998 198 µM 0.0242255151319651 0.491454088858553 no 1641 0.490336362984034 2353 5450317 SGTC_1366 1683-0113 21.9 µM 0.0236406016866363 0.491684429977788 no 1642 0.490569642864517 2359 708623 SGTC_1418 3966-3099 2.4 µM 0.0232488355720223 0.491838710505608 no 1643 0.490725891983223 2364 740335 SGTC_2714 st079313 56.9 µM 0.0230466147497812 0.491918347109608 no 1644 0.490806544808576 2363 2939799 SGTC_1482 3346-2049 8.48 µM 0.0230184702458956 0.491929430725352 no 1645 0.490817769863307 2359 3826804 SGTC_1513 0337-0559 19 µM 0.0215552883703036 0.492505656252574 no 1646 0.491401349973778 2348 775073 SGTC_2382 9035899 200 µM 0.0204994332341876 0.492921479471987 no 1647 0.49182248209794 2371 6462679 SGTC_1882 5615643 20 µM 0.0203724159186932 0.492971502722283 no 1648 0.491873144095386 2371 2253075 SGTC_1279 0874-0590 65.2 µM 0.019956884269509 0.493135152388269 no 1649 0.492038883538557 2353 3523074 SGTC_805 3852-0218 479 µM 0.0195717858739123 0.493286817496886 no 1650 0.492192485566098 2375 6615355 SGTC_2749 bexarotene 57.39 µM 0.0177718686272093 0.493995699865824 no 1651 0.492910423399333 2349 82146 An retinoic acid receptor inhibitor. SGTC_151 3013-0144 2.285 µM 0.0174991404082738 0.49410311330558 no 1652 0.493019209298466 2365 906558 YHR107C CDC12 SGTC_2825 7998094 58.44 µM 0.017265887750298 0.494194979717548 no 1653 0.49311224958833 2348 2987815 SGTC_2343 7990716 14.84 µM 0.0167696382679596 0.494390428280774 no 1654 0.49331019582132 2367 6456862 SGTC_1916 st067606 49.2 µM 0.016239308099246 0.494599301058014 no 1655 0.493521738131939 2374 19590279 SGTC_2258 7960471 200 µM 0.0157566877024395 0.494789384428368 no 1656 0.493714251174662 2340 2974708 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0155442080062773 0.494873071399127 no 1657 0.493799007928381 2382 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1415 3966-0071 78.1 µM 0.0137372080789674 0.495584782735554 no 1658 0.494519819244797 2385 2893185 SGTC_2949 9072542 2.23 µM 0.0137090850135095 0.495595859501802 no 1659 0.494531037668259 2362 16457352 SGTC_1500 4488-1866 171 µM 0.0130557850952811 0.495853174155804 no 1660 0.494791643285871 2378 2900003 SGTC_404 fumagillin 50 µM 0.0128758628772866 0.495924040266296 no 1661 0.494863415832528 2352 12015870 A methionine aminopeptidase binder. SGTC_2852 9023854 51.95 µM 0.0126636704068975 0.496007616852498 no 1662 0.494948061478655 2378 19798528 SGTC_1233 0325-0408 14.2 µM 0.012488721088497 0.496076524551078 no 1663 0.495017850639434 2379 12874 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0106289709366551 0.496809035535869 no 1664 0.495759733937053 2379 279621 SGTC_505 gw-5074 63.9 µM 0.00986441541159338 0.497110178883055 no 1665 0.496064731442303 2379 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1927 st060202 13.8 µM 0.00883292044568195 0.497516466990782 no 1666 0.49647622039602 2391 688887 SGTC_2455 5377712 9.75 µM 0.00813000565867838 0.49779333452465 no 1667 0.49675663273236 2377 2243908 SGTC_181 1447-1644 8.07 µM 0.00776841642161669 0.497935759494369 no 1668 0.49690088140877 2384 534600 SGTC_2228 7354201 200 µM 0.00743668118288324 0.498066425621355 no 1669 0.497033220796212 2375 753451 SGTC_2190 6049624 200 µM 0.00671494257355824 0.498350709620114 no 1670 0.497321145628748 2379 2265554 SGTC_1377 2944-0135 198 µM 0.00654274167836783 0.498418537572871 no 1671 0.497389842337141 2389 1894137 SGTC_2114 5491910 81.25 µM 0.00594551298393351 0.498653779430764 no 1672 0.497628097466155 2396 2849228 SGTC_2591 skatole 100 µM 0.00518881812624641 0.49895183392996 no 1673 0.497929970352987 2385 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_432 NS 1619 61.3 µM 0.00408346549639171 0.499387222227001 no 1674 0.498370937490282 2363 4552 A K+/calcium channel activator. SGTC_424 splitomicin 100 mM 0.003597405791627 0.499578676963402 no 1675 0.498564845825427 2385 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2020 4017018 200 µM 0.00281797079776305 0.499885689886477 no 1676 0.498875793791715 2397 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2903 5923464 63.88 µM 0.00264066320170108 0.499955529881141 no 1677 0.498946529024868 2391 2876576 SGTC_2029 5175081 200 µM 0.00262050972277001 0.499963468169825 no 1678 0.498954569071892 2395 1380876 SGTC_2484 5809818 12.04 µM 0.00243501798864664 0.499963468169825 no 1679 0.499028569330777 2403 2870548 SGTC_72 0744-0168 198.391 µM 0.00155646268451231 0.499617412557883 no 1680 0.499379061477993 2396 677577 SGTC_3000 9075062 71.4286 µM 0.00137281602043741 0.499545075695217 no 1681 0.499452325818262 2400 17057871 SGTC_1981 st071826 47 µM 0.00122152188790479 0.499485482231333 no 1682 0.499512683393668 2393 11838600 SGTC_2857 9024691 58.44 µM 0.000902647673902373 0.499359880446876 no 1683 0.499639895727475 2403 16478292 SGTC_530 4358-1714 28 µM 0.000480691918489214 0.499193675837798 no 1684 0.499808231677253 2400 1564641 SGTC_2890 9046729 58.44 µM 0.000336130989085001 0.499136734607625 no 1685 0.499865903139226 2404 903329 SGTC_1590 st077108 57.8 µM 0.000236116166185103 0.499097339692297 no 1686 0.499905803279098 2405 5489485 SGTC_2304 7443016 91.4 µM 0.000107327941880854 0.499046611212833 no 1687 0.499957182346197 2403 939854 SGTC_2346 9031566 143.75 µM -0.00181153710382662 0.498290790457719 no 1688 0.499277301652043 2409 4771086 SGTC_2211 7117706 200 µM -0.00194629080228096 0.498237712592451 no 1689 0.499223542799223 2407 822771 SGTC_1553 gossypol 38.6 µM -0.00242471256722326 0.498049268256994 no 1690 0.499032680586963 2412 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1739 st037196 92.5 µM -0.00269084483400043 0.497944442279202 no 1691 0.498926509521178 2410 612214 SGTC_492 tmb-8 126 µM -0.00342409401892983 0.497655625885445 no 1692 0.498633986793065 2413 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_742 0kpi-0133 140 µM -0.00420496011046828 0.497348055226076 no 1693 0.498322468568133 2416 2728852 SGTC_2330 7979373 200 µM -0.00525762916480063 0.496933428257001 no 1694 0.497902519094821 2410 1863007 SGTC_1846 st056244 14.8 µM -0.00538659648654375 0.496882630621019 no 1695 0.497851069306083 2431 5393182 SGTC_874 0599-0792 117 µM -0.00623328882090481 0.496549136820902 no 1696 0.497513293646434 2413 765305 SGTC_3110 9122132 49.47 µM -0.00650439249797947 0.496442355443876 no 1697 0.497405141121078 2463 918317 SGTC_1729 st035615 45.989 µM -0.0066655308087015 0.496378886964634 no 1698 0.497340857629745 2456 17385451 SGTC_1354 1498-1681 81 µM -0.00694860864461311 0.496267389681644 no 1699 0.497227928529115 2427 5754243 SGTC_878 0828-0289 13.7 µM -0.00851973629578408 0.495648567316046 no 1700 0.496601158091794 2428 745350 YLR208W SEC13 SGTC_2956 9076196 2.52 µM -0.00988669769866127 0.49511016867741 no 1701 0.496055842529351 2419 16423868 SGTC_2799 7812892 81.82 µM -0.00991722130744831 0.495098146585637 no 1702 0.496043665968219 2427 20205235 SGTC_2700 st077718 96.8 µM -0.0108619321943214 0.494726063054233 no 1703 0.495666801207266 2430 904970 SGTC_2870 9038528 12.99 µM -0.0117221053445089 0.494387279511384 no 1704 0.495323663657146 2482 6463316 SGTC_3322 9139058 2.11 µM -0.0119400479785393 0.49430144233652 no 1705 0.495236723210832 2502 4908926 YPR165W RHO1 SGTC_2303 7774051 200 µM -0.0147518841816959 0.493194019679191 no 1706 0.494115063129894 2459 2953184 SGTC_3352 9151559 45.5865 µM -0.0149976382802461 0.493097233459943 no 1707 0.494017032275328 2445 17159339 SGTC_1951 sophoraflavanone G 9.2 µM -0.0161478031407137 0.492644265396425 no 1708 0.493558238542664 2432 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1828 st055811 49 µM -0.0167023977713617 0.492425853403843 no 1709 0.493337017141851 2429 5877589 SGTC_431 k089-0097 107 µM -0.0169129366415576 0.492342938994298 no 1710 0.493253036148072 2438 5499420 SGTC_2717 st081029 62.2815 µM -0.0171350091523286 0.492255482765461 no 1711 0.493164454871443 2438 5292846 SGTC_3107 9121808 49.47 µM -0.0174286569907903 0.492139839431758 no 1712 0.493047323826141 2447 662681 SGTC_177 1327-0068 8.361 µM -0.0175547823113414 0.492090169414705 no 1713 0.492997014800047 2436 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_887 0885-0007 9.62 µM -0.0177768197748023 0.492002728075387 no 1714 0.49290844848921 2495 5719458 SGTC_932 2857-0803 154 µM -0.0189897725240032 0.491525057863837 no 1715 0.492424632141784 2546 674898 SGTC_2973 9094665 17.96 µM -0.0194394812460322 0.491347962128725 no 1716 0.492245257436009 2445 25237061 YIL048W NEO1 SGTC_1490 4089-0339 670 nM -0.0194739656015318 0.49133438222572 no 1717 0.492231502772345 2442 742542 SGTC_1284 0929-0043 16 µM -0.0203977589525863 0.490970597162473 no 1718 0.491863035788133 2477 1239883 SGTC_1871 st057448 67.3 µM -0.0211070081955973 0.490691303544631 no 1719 0.49158014720484 2460 691747 SGTC_528 3492-0019 172 µM -0.0212026458293454 0.490653642968373 no 1720 0.491542001845644 2437 2869262 SGTC_2491 paeonol 100 µM -0.0212381828430633 0.49063964907984 no 1721 0.491527827820037 2442 11092 Increases levels of cortical cytochrome oxidase. SGTC_156 3474-0145 5.642 µM -0.0215070099279711 0.490533789792294 no 1722 0.491420605821724 2428 2265471 SGTC_896 0964-0007 44.5 µM -0.0231823729962221 0.489874077164457 no 1723 0.490752399570486 2430 6756758 SGTC_613 3914-0030 117 µM -0.0247818231089809 0.489244282824781 no 1724 0.490114494832062 2427 1145395 SGTC_2182 6325192 200 µM -0.0260378554392231 0.488749730287771 no 1725 0.489613572201836 2454 736248 SGTC_207 4185-0010 4.486 µM -0.0261949275490047 0.488687885620448 no 1726 0.48955093086264 2441 3761753 SGTC_2620 irigenin 100 µM -0.0310010920067476 0.486795672702565 no 1727 0.48763433439859 2493 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_925 2064-1272 59.6 µM -0.0316818044782023 0.486527695569423 no 1728 0.48736290276271 2488 6815817 SGTC_2429 5902844 64.44 µM -0.032790952480781 0.486091068642721 no 1729 0.48692064660441 2500 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2675 theaflavin digallate 100 µM -0.0328557091524106 0.486065577057565 no 1730 0.486894826342911 2485 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2176 5809774 33.9695 µM -0.0328932924093127 0.486050782364152 no 1731 0.486879840892521 2481 2870539 SGTC_2727 riluzole 51.77 µM -0.0337288626212088 0.485721864160279 no 1732 0.486546681509194 2462 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1898 st060199 18.6 µM -0.0345297323564834 0.485406614746581 no 1733 0.486227366743742 2455 688866 SGTC_35 0133-0054 64.071 µM -0.0353065047274537 0.48510085958158 no 1734 0.48591766827186 2498 99677 SGTC_1664 st014217 9.02 µM -0.0355425292324527 0.485007956727736 no 1735 0.485823567179912 2484 3982782 SGTC_3165 9101544 49.47 µM -0.0364450149587408 0.484652732095889 no 1736 0.485463760627928 2486 5002184 SGTC_2803 7707263 71.43 µM -0.0370628350675446 0.484409560828252 no 1737 0.485217452487753 2487 2199229 SGTC_25 0118-0223 35.662 µM -0.0378859387397168 0.484085599879946 no 1738 0.484889312130558 2480 5333628 SGTC_621 3584-0052 32.1 µM -0.0380042645106178 0.484039029534666 no 1739 0.484842140949198 2475 2273927 SGTC_45 0kpi-0036 14.9 µM -0.038012978308233 0.484035599989749 no 1740 0.484838667157029 2500 2795021 SGTC_546 peri-Naphthalide 147 µM -0.0380288735743748 0.484029343991494 no 1741 0.484832330445109 2521 223824 A penicillin ester. SGTC_1157 4092-0394 27.6 µM -0.0385352342765446 0.483830054542344 no 1742 0.484630469723264 2575 3659885 SGTC_1629 st005085 44.9 µM -0.0387702653184616 0.483737554249235 no 1743 0.484536775920714 2479 24207091 SGTC_2449 5812982 45.77 µM -0.0398497364821759 0.483312722115693 no 1744 0.484106461859419 2461 776185 SGTC_1919 st067113 52.3 µM -0.0407084934987398 0.482974766821067 no 1745 0.483764145188591 2529 1268243 SGTC_3066 9117245 49.47 µM -0.0412024976151975 0.482780361934196 no 1746 0.483567231278147 2493 17176980 SGTC_1799 st045822 46.1415 µM -0.0415395397387981 0.482647728471291 no 1747 0.48343288594474 2478 3674992 SGTC_451 chloral hydrate 100 µM -0.0417261706567042 0.482574285939686 no 1748 0.483358495479107 2537 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2687 chenodiol 100 µM -0.0420221897756558 0.482457798450791 no 1749 0.483240504428065 2502 5702181 A cholesterol synthesis inhibitor. SGTC_1084 voriconazole 435 nM -0.0432212826104862 0.481985954779205 no 1750 0.482762569934807 2485 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2362 9071156 126 µM -0.044147715293126 0.481621420267266 no 1751 0.482393329266615 2520 653133 SGTC_2225 6654152 15.4 µM -0.0442615628725571 0.481576624357021 no 1752 0.482347955007135 2487 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_779 1360-0071 233 µM -0.0473139253555497 0.480375691698175 no 1753 0.481131514841918 2532 7566 SGTC_2519 cryptotanshinone 88.04 µM -0.0479045659000742 0.480143328149436 no 1754 0.480896150254241 2504 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2219 9098279 200 µM -0.0480573467903363 0.4800832238046 no 1755 0.480835269616741 2489 902349 SGTC_1783 st039459 87.517 µM -0.0495654484933805 0.479489957724972 no 1756 0.480234340440369 2599 729761 SGTC_2981 9013952 38.96 µM -0.0496187244473777 0.479469000534273 no 1757 0.480213112529547 2541 2996344 SGTC_584 0986-0246 15.4 µM -0.049763167934622 0.479412181007665 no 1758 0.480155559014572 2488 53315 YDR232W HEM1 SGTC_2189 6047310 154.431 µM -0.0498937169871835 0.479360827474724 no 1759 0.480103542093698 2474 711535 SGTC_2748 diazoxide 86.69 µM -0.052483628982638 0.47834211658303 no 1760 0.479071669767515 2547 3019 A potassium channel activatior. SGTC_1033 k072-0102 21.3 µM -0.0527410801332011 0.47824085887565 no 1761 0.478969103671527 2488 5965931 SGTC_3278 9139605 49.47 µM -0.0527622262552569 0.478232541989951 no 1762 0.478960679318909 2672 7958859 SGTC_2298 7976326 193.81 µM -0.0529962166327563 0.478140512925655 no 1763 0.478867461084455 2546 2235818 SGTC_2492 derrusnin 100 µM -0.0532753761119962 0.47803072025358 no 1764 0.478756249674304 2474 1715307 Part of coumarin class of compounds. SGTC_66 0109-0187 42.4 µM -0.0542614247049744 0.477642923396882 no 1765 0.478363441438849 2486 759417 SGTC_257 daunorubicin 18.5 µM -0.0544071734132742 0.477585604589882 no 1766 0.478305381882307 2621 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2015 5119600 184 µM -0.0553000279154985 0.477234480562765 no 1767 0.477949719964308 2539 2828786 SGTC_772 k072-0172 35.3 µM -0.0555453641195897 0.47713800271279 no 1768 0.477851995184536 2524 5861980 SGTC_3157 9099274 49.47 µM -0.0565580866355078 0.476739766354969 no 1769 0.47744861154435 2521 17217662 SGTC_1964 st076914 61 µM -0.0568709059486968 0.476616760017963 no 1770 0.477324015240052 2493 24208661 SGTC_1296 1068-0102 11.9 µM -0.0576060019724343 0.476327715462107 no 1771 0.477031234365948 2562 767053 SGTC_1050 3232-1156 69.3 µM -0.0580873480304074 0.476138453788134 no 1772 0.476839526092978 2546 700529 SGTC_2101 5377231 179.231 µM -0.0583604216516956 0.476031085670766 no 1773 0.476730769979183 2549 2844213 SGTC_2955 9076254 12.21 µM -0.0591803713529652 0.475708705240735 no 1774 0.476404221813984 2509 16459619 SGTC_364 0083-0097 67.7 µM -0.0596053229834918 0.47554163283307 no 1775 0.476234989390652 2592 5207356 SGTC_2026 5148700 152 µM -0.0601175054352061 0.475340270796747 no 1776 0.476031023928973 2523 79838 SGTC_1841 st054148 70 µM -0.0603928476969638 0.47523202392732 no 1777 0.475921377486219 2563 675442 SGTC_1467 k284-1082 293 µM -0.0609492515695832 0.47501328729627 no 1778 0.475699812622302 2523 3334705 SGTC_270 tamoxifen 5.46 µM -0.0614969813701779 0.474797968020876 no 1779 0.47548170918788 2512 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_703 3875-0075 71.8 µM -0.0628085627183996 0.474282399406091 no 1780 0.474959473635381 2542 2850814 SGTC_2432 5630864 12.22 µM -0.0634800686974996 0.474018454195525 no 1781 0.474692115052131 2611 5714970 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0639865668731595 0.473819375245739 no 1782 0.474490461485161 2729 5282309 SGTC_3356 9151811 4.48 µM -0.0644148351756751 0.473651049622441 no 1783 0.474319958898372 2522 1859254 YPR165W RHO1 SGTC_2166 5933061 31.504 µM -0.0645801986925113 0.473586056769983 no 1784 0.474254125473659 2740 2877375 SGTC_2686 alizarin 95.37 µM -0.0647175719760641 0.47353206545847 no 1785 0.474199435869203 2558 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_282 k297-0036 65.7 µM -0.0648395058835087 0.473484142634894 no 1786 0.474150893233797 2584 5061378 SGTC_858 0438-0351 2.77 µM -0.0649584108422594 0.473437410627222 no 1787 0.474103556811015 2535 2799119 SGTC_70 0141-0289 43.283 µM -0.0650702907349091 0.473393439943685 no 1788 0.474059017422083 2635 352408 SGTC_3220 9131269 49.47 µM -0.0652247490302557 0.473332735763057 no 1789 0.473997528102587 2510 17722206 SGTC_991 3996-0057 64.7 µM -0.0655519342629244 0.47320414962762 no 1790 0.473867278827376 2579 715343 SGTC_281 1672-3440 14.9 µM -0.0668159740860046 0.472707399291158 no 1791 0.473364103173091 2561 6833000 SGTC_1067 clotrimazole 1.36 µM -0.0672537317496019 0.472535376381269 no 1792 0.473189855080899 2538 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3095 9117207 49.47 µM -0.0680413370875861 0.47222588892456 no 1793 0.472876364137529 2521 17015229 SGTC_2420 aureobasidin a 50 nM -0.0682639123714256 0.472138431579998 no 1794 0.472787775423058 2743 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2393 9031399 185.94 µM -0.0682939201792379 0.472126640601728 no 1795 0.472775831912638 2586 1526623 YDL150W RPC53 SGTC_1505 k297-0037 20.6 µM -0.0683386373827579 0.472109069900856 no 1796 0.472758033910643 2548 4089396 SGTC_1638 st008370 60.6 µM -0.0688541442035716 0.471906516078885 no 1797 0.472552859734487 2508 24207134 SGTC_3048 9093155 49.47 µM -0.0692901278412432 0.471735214311053 no 1798 0.472379341846772 2523 25236002 SGTC_2197 6588183 93.1375 µM -0.0709392225076834 0.471087318213205 no 1799 0.471723063472796 2536 884136 SGTC_1248 0469-0687 58.6 µM -0.0710208892587955 0.471055234965033 no 1800 0.471690565122164 2585 4017482 SGTC_2161 5662504 8.5105 µM -0.0716387990223331 0.470812491698806 no 1801 0.471444681114607 2563 2859334 SGTC_411 enrofloxacin 100 µM -0.0725417962608142 0.470457772538798 no 1802 0.471085372229503 2571 71188 A bacterial gyrase inhibitor. SGTC_1479 0549-0158 134 µM -0.072616147044041 0.470428566793124 no 1803 0.471055788580204 2559 5440202 SGTC_1243 0416-0003 5.65 µM -0.0740402414337089 0.469869198882137 no 1804 0.470489182541366 2599 2141977 SGTC_2766 oltipraz 83.91 µM -0.0746783635651482 0.469618571066059 no 1805 0.470235311483836 2583 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2092 5303694 80.6725 µM -0.0747178957094503 0.469603044879935 no 1806 0.470219584378438 2559 1963699 SGTC_817 1391-0715 46 µM -0.0752191835608914 0.469406168899033 no 1807 0.470020160658845 2595 1353946 SGTC_2705 st078069 42.8 µM -0.0767528625591789 0.468803877880889 no 1808 0.469410075145244 2602 1530061 SGTC_1155 4088-0394 48.2 µM -0.077408301815041 0.468546502050012 no 1809 0.469149368353792 2529 2326248 SGTC_3251 9135047 49.47 µM -0.0774807326516698 0.468518060940933 no 1810 0.469120559154127 2646 17682963 SGTC_247 mechlorethamine 29.705 µM -0.0780330663624092 0.468301183702634 no 1811 0.468900875011696 2528 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1889 st059080 5.18 µM -0.0780848392050216 0.468280855257877 no 1812 0.468880283465669 2533 176925 Isolated from Daphnopsis sellowiana. SGTC_372 0155-0182 15.9 µM -0.0788518982057484 0.467979681658505 no 1813 0.468575211859792 2545 771486 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0799120464003594 0.467563461421231 no 1814 0.46815360441518 2666 165506 SGTC_1214 0358-0031 63.7 µM -0.0801317414431016 0.467477212313109 no 1815 0.468066238944838 2781 4301366 SGTC_2906 7926292 26.41 µM -0.0804367281275895 0.467357481467365 no 1816 0.467944958352977 2618 2966319 SGTC_775 4577-0580 57.3 µM -0.0828389945546288 0.46641451033447 no 1817 0.466989781248439 2744 2006902 SGTC_446 go6976 132 µM -0.0830197407310532 0.466343568882652 no 1818 0.466917921481939 2573 3501 A protein kinase C inhibitor. SGTC_2544 sphondin 68.51 µM -0.0840819461439661 0.465926683298397 no 1819 0.466495639348916 2728 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1942 st076330 65.2 µM -0.0851336090665605 0.465513972172958 no 1820 0.466077585558607 2697 24208414 SGTC_2596 sinensetin 100 µM -0.0858243752419299 0.465242910329321 no 1821 0.465803014663205 2604 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2723 salbutamol 83.58 µM -0.0859793578709724 0.465182096190333 no 1822 0.465741413242085 2599 9884233 β2-adrenoceptor agonist SGTC_901 1112-0062 60.1 µM -0.086598429017433 0.464939184971036 no 1823 0.465495357336596 2546 1908457 SGTC_2055 5235184 200 µM -0.087312269316614 0.464659104442965 no 1824 0.465211650881144 2645 2836034 SGTC_2625 euphol 100 µM -0.0874814032723903 0.464592746043456 no 1825 0.46514443339657 2615 6708538 A triterpene alcohol. SGTC_2978 9011784 42.97 µM -0.0881093248403964 0.464346394501777 no 1826 0.464894892527797 2717 2994934 SGTC_840 0245-0196 390 µM -0.0913788965114239 0.46306387126684 no 1827 0.463595764864313 2681 3827528 SGTC_1736 st036774 51 µM -0.0917091758394946 0.462934336914603 no 1828 0.463464553426373 2753 1272247 SGTC_1706 st031321 9.9705 µM -0.0917722050425152 0.462909617536385 no 1829 0.463439514004734 2614 6103185 SGTC_760 0568-0725 82.9 µM -0.0918397306892767 0.46288313486002 no 1830 0.463412688455139 2652 3916171 SGTC_2747 doxorubicin 7.63 µM -0.0919079690070003 0.462856372850537 no 1831 0.463385579955596 2557 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2402 5553605 200 µM -0.0929952564317161 0.462429978353384 no 1832 0.462953664856119 2663 6758546 SGTC_1826 st055655 41.6 µM -0.0931975754616005 0.462350640953432 no 1833 0.462873300254475 2609 676168 SGTC_3246 9135460 32.98 µM -0.0948774965782138 0.461691934706189 no 1834 0.462206065501118 2564 41446951 SGTC_3118 9124250 49.47 µM -0.0952569136376917 0.461543177684777 no 1835 0.462055382455523 2644 1504786 SGTC_660 4031-1742 102 µM -0.0955980967893773 0.461409415521893 no 1836 0.461919888410331 2575 6738706 SGTC_283 0987-0079 11.7 µM -0.0961076893642903 0.461209635932974 no 1837 0.461717522175154 2590 411556 SGTC_1662 st014054 52 µM -0.0961200090820313 0.461204806258025 no 1838 0.461712629967924 2559 2838777 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0968681144212527 0.460911538728763 no 1839 0.461415565348899 2591 689007 SGTC_3205 9113483 49.47 µM -0.0969395874266678 0.460883521442653 no 1840 0.461387185307792 2703 17018033 SGTC_3007 9078383 71.4286 µM -0.0974368546979019 0.460688598973293 no 1841 0.461189739070297 2608 6496995 SGTC_1221 2958-7315 257 µM -0.0979706117599157 0.460479383480097 no 1842 0.460977814747991 2657 4562705 SGTC_443 clozapine 122 µM -0.0992000603273994 0.459997521149204 no 1843 0.460489713480875 2563 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2200 6600604 21.907 µM -0.0992488708601084 0.459978391864128 no 1844 0.460470336518709 2578 2904777 SGTC_175 3793-3120 23.7 µM -0.100020445185309 0.459676017308572 no 1845 0.460164046962876 2610 5322297 SGTC_3257 9139206 32.98 µM -0.101579405243559 0.459065143164153 no 1846 0.459545263556382 2650 4910041 SGTC_1408 3909-7976 48.8 µM -0.102002131196467 0.458899515775892 no 1847 0.459377491729521 2607 24152374 SGTC_3241 9133421 49.47 µM -0.1025122559264 0.458699654354156 no 1848 0.4591750426383 2568 17018221 SGTC_3292 9120825 59.784 µM -0.102524263210672 0.458694950153958 no 1849 0.459170277531462 2588 24824900 SGTC_1669 st015249 58.4 µM -0.102975852284688 0.45851803130495 no 1850 0.458991068067892 2620 722793 SGTC_2162 5663267 200 µM -0.104041715429154 0.458100491225657 no 1851 0.458568122030395 2590 6456493 SGTC_1384 3089-0840 101 µM -0.104653213729117 0.457860964381858 no 1852 0.458325494024683 2591 1069836 SGTC_2123 5259487 200 µM -0.106142020330486 0.457277855789059 no 1853 0.457734836015077 2661 2173474 SGTC_2363 9053361 176 µM -0.107153352035173 0.456881808222159 no 1854 0.457333660983008 2705 6469797 YMR079W SEC14 SGTC_2540 epiandrosterone 100 µM -0.11033669793509 0.455635459632215 no 1855 0.456071177091661 2617 441302 A steroid. SGTC_1383 3049-0032 20.7 µM -0.110959205620088 0.455391785083524 no 1856 0.455824348054466 2716 712864 SGTC_1171 0368-0077 21.4 µM -0.111090295728078 0.455340473278016 no 1857 0.455772371998391 2601 3239779 SGTC_666 0272-0154 136 µM -0.111390654903948 0.455222908318872 no 1858 0.45565328512529 2636 6870312 SGTC_2252 omeprazole 400 µM -0.113658893090833 0.454335214175724 no 1859 0.454754099922742 2673 4594 A proton pump inhibitor. SGTC_968 1309-0633 340 µM -0.113891469928665 0.454244206083786 no 1860 0.454661913789153 2609 3761976 SGTC_1630 st005209 31.3 µM -0.114687037995265 0.453932915838364 no 1861 0.454346594156041 2593 3367314 SGTC_2934 9036370 36.88 µM -0.115448154947964 0.453635132123757 no 1862 0.454044955983149 2702 6462800 SGTC_3265 9137266 49.47 µM -0.115612639413755 0.453570781707623 no 1863 0.453979772640059 2582 17224265 SGTC_747 3448-8087 38.7 µM -0.115999562424762 0.453419412606719 no 1864 0.453826444294794 2662 5168703 SGTC_3263 9137018 49.47 µM -0.116763326689461 0.453120638397554 no 1865 0.453523802984459 2630 43844957 SGTC_520 3584-0023 682 µM -0.116795197991236 0.453108171352671 no 1866 0.453511174578185 2707 1340790 SGTC_3023 9089636 49.47 µM -0.116931250621369 0.453054952388232 no 1867 0.453457266801003 2592 17249241 SGTC_220 paclitaxel 373.376 µM -0.117452386011061 0.452851110512106 no 1868 0.453250786633315 2729 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_582 0987-0078 156 µM -0.118459870643306 0.452457068620176 no 1869 0.452851644873584 2624 1625765 SGTC_715 0868-0130 184 µM -0.118892317798055 0.452287946587702 no 1870 0.452680334050599 2688 2876258 SGTC_1385 3091-4834 14.1 µM -0.119269989774138 0.45214025318826 no 1871 0.452530729223597 2715 4072814 SGTC_949 1165-0505 146 µM -0.119632583703877 0.451998462480581 no 1872 0.452387103508699 2629 6244267 SGTC_1217 1183-1422 255 µM -0.121658404907079 0.451206387471446 no 1873 0.451584778269822 2733 2849664 SGTC_575 k072-0246 11.9 µM -0.121842802749294 0.451134299431589 no 1874 0.451511757386727 2619 6796779 SGTC_1488 4013-0813 75.9 µM -0.122728986409901 0.450787879491649 no 1875 0.451160854771469 2617 2910057 SGTC_541 4513-1321 94 µM -0.123784961476968 0.450375134997507 no 1876 0.450742769615797 2646 747515 SGTC_85 0868-0259 160.055 µM -0.124535340788432 0.450081870010113 no 1877 0.450445710132433 2698 83173 SGTC_1909 st060837 51.5 µM -0.124748722398409 0.449998480683683 no 1878 0.450361241875537 2678 678937 SGTC_1011 4112-3381 17.4 µM -0.12518545175835 0.44982781416028 no 1879 0.450188367226098 2802 2877139 SGTC_2593 nobiletin 86.24 µM -0.125862722693324 0.449563166380324 no 1880 0.449920295469822 2709 72344 An anti-infammatory. SGTC_1569 carminic acid 40.6 µM -0.125969434195897 0.449521470247622 no 1881 0.449878059889882 2679 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3277 9138724 49.47 µM -0.126042440270758 0.449492944393793 no 1882 0.44984916498224 2696 15943418 SGTC_1313 1220-0047 237 µM -0.126884307725528 0.449164018226245 no 1883 0.449515983434453 2671 3528706 SGTC_1968 st069590 43.6 µM -0.126935784964394 0.449143906677065 no 1884 0.449495611704911 2720 6384066 SGTC_741 4582-0002 126 µM -0.127657416251379 0.448861987634646 no 1885 0.449210045595531 2636 2912688 SGTC_1679 SEC14.276 6.7 µM -0.127848214557953 0.448787452942431 no 1886 0.449134546705244 2793 1005053 YMR079W SEC14 SGTC_734 2023-0417 80 µM -0.127970116184444 0.448739833443821 no 1887 0.449086311195422 2744 3935732 SGTC_2979 9012552 45.46 µM -0.128797102149782 0.448416800215279 no 1888 0.448759099290754 2678 17100905 SGTC_366 0181-0206 4.31 µM -0.130603867803103 0.447711169483878 no 1889 0.448044341437117 2686 274874 SGTC_1450 4112-4260 37.6 µM -0.130806304997408 0.447632118082405 no 1890 0.447964267594459 2611 1633175 SGTC_1258 0671-0043 57.1 µM -0.131041511573466 0.447540272902171 no 1891 0.447871234516702 2697 4298767 SGTC_3153 9100258 49.47 µM -0.131494932731397 0.447363225641574 no 1892 0.447691897432423 2671 25236848 SGTC_1560 lithocholic acid 53.1 µM -0.133162637638553 0.446712127766249 no 1893 0.447032379243043 2643 9903 A bile acid which acts as a detergent. SGTC_2355 9061122 103.12 µM -0.134637717608937 0.44613635329094 no 1894 0.446449159383115 2770 5302957 SGTC_1391 3442-0225 151 µM -0.134815768217709 0.446066861667764 no 1895 0.446378769211428 2643 5227075 SGTC_2325 6158266 200 µM -0.136228383184125 0.44551558906131 no 1896 0.445820368893649 2714 3623240 SGTC_2692 st077426 47.7 µM -0.136335064724737 0.44547396088342 no 1897 0.445778202512309 2719 25238571 SGTC_1700 st030840 7.9285 µM -0.136680433107673 0.44533919889682 no 1898 0.445641698241358 2761 5499307 SGTC_2875 9039966 71.43 µM -0.136817469850195 0.445285729209385 no 1899 0.445587537278221 2750 6463691 SGTC_2856 9022925 19.48 µM -0.137787888743957 0.444907114806666 no 1900 0.445204028219026 2790 4944862 SGTC_2806 7952793 58.44 µM -0.140941705213837 0.443676984349657 no 1901 0.443957997487389 2788 2972490 SGTC_3129 9127257 49.47 µM -0.141019386775562 0.443646691839687 no 1902 0.44392731347844 2680 837894 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.141150752402344 0.443595465573647 no 1903 0.443875425172419 2770 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1451 4152-0210 104 µM -0.142370937516114 0.443119697307977 no 1904 0.443393508511598 2675 659563 SGTC_2096 5468907 200 µM -0.142889902638268 0.4429173699265 no 1905 0.443188566633733 2799 759785 SGTC_2551 apiole 73.87 µM -0.143003688329855 0.442873010626598 no 1906 0.443143634134171 2649 10659 A possible DNA adduct former. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.144394768347917 0.442330756772721 no 1907 0.44259437388601 2640 6708784 An antioxidant flavonoid SGTC_3344 9148862 3.898 µM -0.144462047384344 0.442304533609586 no 1908 0.442567811919084 2791 4905352 SGTC_1085 doxorubicin 7.67 µM -0.144823748088801 0.442163558866519 no 1909 0.442425015815442 2720 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1972 st070201 17.4 µM -0.145265640190952 0.441991339048273 no 1910 0.442250571040308 2742 2829099 SGTC_1704 st028805 70.8 µM -0.145481691869391 0.441907140625186 no 1911 0.442165284867161 2707 2876101 SGTC_823 0417-1665 178 µM -0.146048161508626 0.441686391792915 no 1912 0.441941684310184 2755 3429856 SGTC_252 miconazole 1.30953 nM -0.146277921053777 0.441596861435957 no 1913 0.441850997406646 2726 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2721 ifenprodil 61.44 µM -0.146660625808866 0.441447739575784 no 1914 0.441699949257537 2795 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3089 9117425 49.47 µM -0.147548284291971 0.441101893224696 no 1915 0.441349635692942 2736 9401657 SGTC_933 2914-0560 114 µM -0.148393481422492 0.440772632250641 no 1916 0.441016122095221 2847 463887 SGTC_3111 9122088 49.47 µM -0.149385883640968 0.440386077295031 no 1917 0.440624574983295 2741 16876704 SGTC_3354 9151612 71.43 µM -0.149519174641518 0.440334162850087 no 1918 0.440571990128376 2790 27261949 SGTC_269 exalamide 29 µM -0.150121374366612 0.440099629696463 no 1919 0.440334428386794 2707 3316 A derivative of salicylamide. SGTC_391 gliotoxin 8.33 µM -0.150152133176612 0.440087650910854 no 1920 0.440322294921017 2796 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3036 9090181 49.47 µM -0.150316444375384 0.440023662088073 no 1921 0.440257479828973 2655 25236586 SGTC_1407 3909-7909 12.3 µM -0.152176093480688 0.439299555937363 no 1922 0.439524024492387 2686 4411780 SGTC_3299 9121982 43.1275 µM -0.153895655902847 0.438630177067652 no 1923 0.438846004693967 2714 17594604 YPL160W CDC60 SGTC_1973 st070275 50.2 µM -0.154432268510044 0.43842132421823 no 1924 0.438634456122643 2621 17118334 SGTC_868 0527-0199 213 µM -0.15730643327341 0.437302975334996 no 1925 0.437501675182209 2732 2849450 SGTC_1956 st077085 54 µM -0.157983666847059 0.43703953363778 no 1926 0.437234834524288 2725 24208685 SGTC_2415 st077333 57.7 µM -0.159543675701576 0.436432801577263 no 1927 0.436620275367529 2790 2766255 SGTC_1832 st054113 55 µM -0.161984362029049 0.435483849356199 no 1928 0.435659084261714 2694 1251267 SGTC_3256 9138902 49.47 µM -0.16298616804972 0.435094448878769 no 1929 0.435264662670312 2671 17228773 SGTC_515 4092-1064 102 µM -0.164356007901902 0.434562096151406 no 1930 0.434725446583387 2883 717353 SGTC_961 1252-1571 372 µM -0.164414277945378 0.434539453634029 no 1931 0.434702512174454 2825 6813498 SGTC_851 0394-0702 453 µM -0.16592137221287 0.433953903198633 no 1932 0.43410941401281 2704 762646 SGTC_3231 9132313 49.47 µM -0.166394142097357 0.433770247994165 no 1933 0.433923391812038 2759 4905967 SGTC_280 3448-3607 3.04 µM -0.166514196246635 0.433723613268436 no 1934 0.43387615606984 2737 626179 SGTC_2440 5628896 157.78 µM -0.168161743330154 0.433083721318093 no 1935 0.433228018350556 2725 5522048 SGTC_1790 st045711 43.5 µM -0.169558939993059 0.432541200520017 no 1936 0.43267850800285 2807 585119 SGTC_153 4077-0274 519.67 µM -0.170096491996471 0.432332506995087 no 1937 0.432467126148444 2880 3121976 SGTC_15 0266-0086 27.098 µM -0.170135125607953 0.43231750901533 no 1938 0.432451934976988 2747 1712902 YIL048W NEO1 SGTC_3131 9127911 49.47 µM -0.170163031290501 0.432306675792594 no 1939 0.432440962210206 2950 45595681 SGTC_2153 5569715 200 µM -0.17039068171928 0.432218301866351 no 1940 0.432351449949587 2708 2054701 SGTC_2106 5357045 167.29 µM -0.171120497276103 0.431935010255936 no 1941 0.432064509543498 2815 668842 SGTC_1398 3558-0053 112 µM -0.171413387721043 0.431821329163456 no 1942 0.431949364346846 2707 4532369 SGTC_124 0136-0217 7.121 µM -0.172678609335384 0.431330317101798 no 1943 0.43145202923694 2772 3976905 SGTC_2841 9004761 38.96 µM -0.173050820518702 0.431185888120374 no 1944 0.43130574058373 2731 2991039 SGTC_2048 5246248 200 µM -0.175526697239143 0.430225409566199 no 1945 0.430332897521833 2760 677046 SGTC_1189 1431-2119 7.28 µM -0.17734199676679 0.429521453737532 no 1946 0.429619882451677 2718 3107275 SGTC_1124 fisetin 1.16336 µM -0.178110114259493 0.429223652433892 no 1947 0.429318249503641 2794 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1906 st060206 94.7 µM -0.178241383017917 0.429172763193801 no 1948 0.429266705546518 2850 5133468 SGTC_2264 7948757 110.76 µM -0.17852992653775 0.429060907049681 no 1949 0.429153410361926 2700 2971411 SGTC_598 3937-0236 20.2 µM -0.181542601394946 0.427893362053663 no 1950 0.427970848784784 2789 1379313 SGTC_1320 1313-0481 95.3 µM -0.181841795703916 0.427777445282577 no 1951 0.427853441534713 2827 6813365 YLR208W SEC13 SGTC_3086 9117350 49.47 µM -0.183972191860763 0.426952247251399 no 1952 0.427017635115449 2727 2679265 SGTC_2249 haloperidol 116.36 µM -0.184554577500493 0.426726718629212 no 1953 0.426789207861726 2712 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.185144400393311 0.426498334347394 no 1954 0.426557888541136 2748 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_340 k038-0059 454 µM -0.18553952080092 0.426345354250478 no 1955 0.426402942615811 2731 23733424 SGTC_927 2425-1185 123 µM -0.185694439513908 0.426285376874325 no 1956 0.426342194553769 2704 730375 SGTC_2942 9052777 62.25 µM -0.186067897763715 0.426140798086464 no 1957 0.426195758070357 2766 6469503 SGTC_3303 9125618 40.5795 µM -0.18841955117236 0.425230619390716 no 1958 0.425273887277203 2841 22695467 SGTC_2995 9067767 71.4286 µM -0.191072354389497 0.424204362706735 no 1959 0.424234453292498 2828 11673567 SGTC_624 k048-0052 28 µM -0.192744554860752 0.423557723022429 no 1960 0.423579513957757 2799 6835531 SGTC_295 k015-0027 31 µM -0.193275929594043 0.423352283498018 no 1961 0.423371438152133 2844 3887424 SGTC_2145 5634607 200 µM -0.194297682860013 0.422957312954571 no 1962 0.422971399936877 2741 308662 SGTC_783 0848-0141 92.7 µM -0.194370873356237 0.422929023288794 no 1963 0.422942747338287 2732 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_920 mycophenolic acid 780.421 nM -0.195337569357528 0.422555412301703 no 1964 0.422564343712676 2795 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3317 9138495 8.753 µM -0.195473345558394 0.422502942761686 no 1965 0.42251120117105 2753 17020139 SGTC_1805 st050013 60.3 µM -0.195930256155737 0.422326383712927 no 1966 0.422332377614284 2811 4037144 SGTC_2807 7945238 51.95 µM -0.196525868965787 0.422096250896795 no 1967 0.422099293467188 2872 17148797 SGTC_1208 2323-2347 50.3 µM -0.196728791391805 0.422017851821089 no 1968 0.422019889043567 2894 5412760 SGTC_125 0133-0007 11.75 µM -0.196952970481701 0.42193124382644 no 1969 0.421932170480767 2868 26541 SGTC_176 1486-1328 72.834 µM -0.196985157860508 0.421918809058916 no 1970 0.421919576267123 2833 22310231 SGTC_2139 5578692 56.4705 µM -0.197005379175885 0.421910997112633 no 1971 0.42191166415185 2813 650991 YMR113W FOL3 SGTC_1255 0566-0045 221 µM -0.197576525265359 0.421690363308848 no 1972 0.421688201427387 2898 2788469 SGTC_92 0063-0024 660.874 µM -0.198310142164864 0.421407003083758 no 1973 0.421401208486098 2692 3594437 SGTC_585 0kpi-0023 191 µM -0.199893144646026 0.420795705709026 no 1974 0.420782076012799 2889 64601 SGTC_94 0334-0113 514.748 µM -0.202977324577185 0.419605258428152 no 1975 0.419576377826219 2778 6795178 SGTC_2552 juarezic acid 87.02 µM -0.203170036897422 0.419530898655924 no 1976 0.419501065748728 2733 1549512 SGTC_3175 9106517 49.47 µM -0.20318494270806 0.419525147235272 no 1977 0.419495240672805 2856 41468073 SGTC_2159 5658611 73.75 µM -0.205995447670926 0.418441019881672 no 1978 0.418397233641557 2767 793844 SGTC_2131 toluylene red 5.2905 µM -0.207301861242544 0.417937292757941 no 1979 0.41788706032943 2813 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_289 k017-0060 526 µM -0.211092077524341 0.416476625202632 no 1980 0.416407711083592 2782 5512909 SGTC_2456 5770359 74.46 µM -0.212128475134125 0.416077419753058 no 1981 0.416003402619365 2934 3118787 SGTC_464 bw-b 70c 158 µM -0.217878458766071 0.413864192203199 no 1982 0.413761905687854 2928 5353454 SGTC_2863 9028737 58.44 µM -0.219151060071401 0.413374721877483 no 1983 0.413266188583933 2895 6460917 SGTC_162 k030-0015 37.8 µM -0.219308558378115 0.413314153924663 no 1984 0.413204847776713 2881 1809920 YMR134W ERG29 SGTC_1197 1601-0112 267 µM -0.220085014669316 0.413015588081932 no 1985 0.412902472629621 2797 7350313 SGTC_1139 k015-0024 46.9 µM -0.221298820350887 0.412548951883913 no 1986 0.412429884219228 2846 2766652 SGTC_2677 mitomycin C 100 µM -0.222365247953423 0.4121390757593 no 1987 0.412014781357779 2816 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1343 1487-0095 224 µM -0.223290564204856 0.411783512700393 no 1988 0.411654685283967 2855 4560101 YGL055W OLE1 SGTC_1035 k081-0041 55.2 µM -0.227779881675412 0.410059475680574 no 1989 0.409908683846767 2862 731709 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.229461801786916 0.409414011752621 no 1990 0.409255003180898 2918 16725076 SGTC_1363 1636-0063 10.4 µM -0.229818145746338 0.409277290475578 no 1991 0.409116541911171 2815 6072185 SGTC_2184 6075246 200 µM -0.230816635555117 0.408894250902236 no 1992 0.408728628431774 2872 2267320 SGTC_2314 7727897 200 µM -0.232524093625244 0.408239439457387 no 1993 0.408065487981839 2827 900724 SGTC_2712 st079126 47.7 µM -0.232774792443757 0.40814331779608 no 1994 0.407968144003409 2801 3152970 SGTC_2940 9060638 45.86 µM -0.232873636698941 0.408105420955281 no 1995 0.407929765275692 2933 4027022 SGTC_1562 morin hydrate 59.1 µM -0.234074647509132 0.407645022754092 no 1996 0.407463513795567 3001 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_778 3456-2434 196 µM -0.235561525819313 0.407075216185059 no 1997 0.406886465640796 2984 5539063 SGTC_1864 st057645 30.4 µM -0.237152079085314 0.406465896625478 no 1998 0.406269405619164 2843 688666 SGTC_2174 5790901 200 µM -0.237290566014463 0.406412854839799 no 1999 0.406215690181772 2902 786020 SGTC_2751 anetholtrithion 17.25 µM -0.237937935815278 0.40616492895893 no 2000 0.405964615890191 2963 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2353 9059630 146.67 µM -0.238298761564351 0.406026758356574 no 2001 0.405824690907659 2937 4779114 SGTC_304 1310-0298 97 µM -0.238615128990779 0.405905621759333 no 2002 0.405702016361127 2839 1550234 SGTC_2457 5731572 11.68 µM -0.238721373267277 0.405864943010634 no 2003 0.405660821186145 2968 2865357 SGTC_1386 3228-0095 33.8 µM -0.239871778937536 0.405424541511162 no 2004 0.405214829681016 2961 870181 SGTC_2755 lomerizine 42.69 µM -0.240142828724098 0.405320794882208 no 2005 0.405109766464692 2877 3949 A calcium channel blocker. SGTC_677 0929-0063 136 µM -0.240504662372907 0.405182310320365 no 2006 0.404969524635637 2824 1539583 SGTC_681 1642-0006 26.6 µM -0.241703312763992 0.404723635848683 no 2007 0.404505031224752 2866 4446530 SGTC_1773 st048542 73.5835 µM -0.242194915486872 0.404535557408201 no 2008 0.404314567322544 2813 3237138 SGTC_1827 berberine 7.24 µM -0.243184803748769 0.404156910764621 no 2009 0.403931119209049 2835 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1412 3909-8563 178 µM -0.244185549852626 0.403774202092072 no 2010 0.403543558967221 2934 23767530 SGTC_636 0kpi-0074 126 µM -0.24430269099887 0.403729410597701 no 2011 0.403498199747519 2929 616434 SGTC_232 clozapine 119 µM -0.244966512508291 0.403475607704716 no 2012 0.403241180311756 2823 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1173 0443-0020 122 µM -0.245743363781969 0.403178641081438 no 2013 0.40294045091647 2849 5331295 SGTC_76 0433-0009 400.328 µM -0.245906617740335 0.403116241150104 no 2014 0.402877260445257 2969 2841569 SGTC_767 0929-0023 86 µM -0.24634227474114 0.40294973373414 no 2015 0.402708643747868 2860 1204563 SGTC_2791 5663188 71.43 µM -0.248389476320073 0.402167532652695 no 2016 0.401916537589817 3011 54690634 SGTC_1829 berberine 14.4 µM -0.248660367304811 0.402064059062856 no 2017 0.401811754163332 3002 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2655 perillic acid 100 µM -0.249641783954762 0.401689239943467 no 2018 0.401432191240015 2853 5702197 An apoptosis inducer. SGTC_1718 roemerine 11.9335 µM -0.249849256267253 0.401610014429968 no 2019 0.401351963210446 2991 235224 An aporphine alkaloid with mutagenic activity. SGTC_384 k007-0144 5.16 µM -0.250755439177093 0.401264026273807 no 2020 0.401001597682528 2907 6824886 SGTC_3332 9141069 11.198 µM -0.253109777079589 0.400365482963046 no 2021 0.400091691905461 2830 17332883 SGTC_1442 4112-3290 3 µM -0.25311505868704 0.400363467805356 no 2022 0.400089651274588 2856 704353 SGTC_1373 2887-0003 58.5 µM -0.254491227917244 0.399838491296417 no 2023 0.399558040086229 2920 776948 SGTC_982 1491-0518 27.5 µM -0.254879201226768 0.399690521179657 no 2024 0.39940820043522 2868 3091256 SGTC_1348 1493-0373 93.8 µM -0.255055281558387 0.399623370210023 no 2025 0.399340201119713 2917 3010129 SGTC_1873 rapamycin 2 nM -0.255664125998247 0.399391200818924 no 2026 0.399105099002072 2861 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2734 clemastine 41.6 µM -0.256400339251042 0.399110509666878 no 2027 0.398820862963124 2867 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2229 7354935 190 µM -0.256475749087252 0.399081761600372 no 2028 0.398791751880393 2946 318112 SGTC_2061 5245884 80.95 µM -0.25931972296485 0.397997970389361 no 2029 0.397694281521362 2847 573863 SGTC_2282 7944268 200 µM -0.259742448221193 0.397836943761865 no 2030 0.397531223560863 3071 2970414 SGTC_2466 5983409 37.09 µM -0.259917598032303 0.397770229913793 no 2031 0.397463668207182 2897 2879657 SGTC_121 0557-0495 61.343 µM -0.26228660991935 0.396868177383762 no 2032 0.396550242251924 2869 3104427 SGTC_2733 amorolfine 100 µM -0.262394871761874 0.396826967487312 no 2033 0.396508512978009 2903 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_61 0978-8327 98.565 µM -0.263138030578813 0.396544115028254 no 2034 0.396222096171805 2918 6150059 YHR072W ERG7 SGTC_3135 9127742 49.47 µM -0.263266939151646 0.396495056883664 no 2035 0.396172419914065 2934 3643468 SGTC_2716 st080858 38.6235 µM -0.263377800193703 0.39645286831562 no 2036 0.396129699808111 3004 5296050 SGTC_226 1,3-diallylurea 8.28947 mM -0.26435006663007 0.396082920821093 no 2037 0.395755092154637 2965 74537 YKL182W FAS1 SGTC_215 1287-0124 461.5 µM -0.264883472276966 0.395879999635779 no 2038 0.395549615456441 2922 5560863 SGTC_1603 st002045 67.8 µM -0.265077204542969 0.395806305896087 no 2039 0.395474993759458 3016 5887985 SGTC_1302 1159-0335 255 µM -0.265882464878007 0.395500033178426 no 2040 0.395164865084129 2871 649284 SGTC_195 4234-0266 16.654 µM -0.268919834803928 0.394345382094103 no 2041 0.393995686535051 2910 2303354 SGTC_711 k292-0785 179 µM -0.269236096429944 0.394225208926757 no 2042 0.393874002259061 2860 4146315 SGTC_733 4069-0007 56.1 µM -0.27030705546891 0.393818340497438 no 2043 0.393462018925912 2894 5717425 YNL287W SEC21 SGTC_774 k060-0086 136 µM -0.270333943437899 0.393808126968967 no 2044 0.393451677023709 3015 5911235 SGTC_271 rotenone 740 µM -0.270633086895202 0.393694500770745 no 2045 0.393336622740375 3011 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1144 3486-0183 12.5 µM -0.270747902544459 0.393650891771345 no 2046 0.393292465690848 2888 6744069 SGTC_908 3448-7491 47.7 µM -0.271903293189558 0.393212128453072 no 2047 0.39284818950383 2873 1203031 SGTC_1645 Cervolide 78 µM -0.272208612630674 0.393096205041512 no 2048 0.392730809940042 2955 23173 A fragrance. SGTC_966 1300-0360 30.2 µM -0.27236600395643 0.393036450546119 no 2049 0.39267030491007 2886 70588 SGTC_907 3448-6986 75.5 µM -0.272507643153059 0.392982678588948 no 2050 0.392615857596537 3072 590582 SGTC_763 3453-1109 128 µM -0.273128409252428 0.392747034815877 no 2051 0.392377254622617 3042 1560353 SGTC_1578 josamycin 24.2 µM -0.2734333721028 0.392631284838032 no 2052 0.392260051302225 2899 5282165 A P450 substrate. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.27428450692361 0.392308283175455 no 2053 0.391932994905899 2946 676296 Flavone; oxidizing agent. SGTC_679 0422-0091 41.4 µM -0.277091784258568 0.391243461575033 no 2054 0.390854815072108 2885 627384 YHR062C RPP1 SGTC_2762 leflunomide 42.06 µM -0.277645078695431 0.391033688644382 no 2055 0.390642412132971 2891 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_171 k064-0041 9.68 µM -0.278541372595775 0.390693940122344 no 2056 0.390298405173633 2918 53325 SGTC_2271 7849410 118.62 µM -0.278572833158935 0.390682016217986 no 2057 0.390286331839436 2968 972430 SGTC_2621 lithochol-11-enic acid 100 µM -0.279339334283841 0.390391535529598 no 2058 0.389992211394001 2968 6708711 SGTC_797 k781-0471 270 µM -0.280589893559087 0.389917742866416 no 2059 0.389512484263254 2918 23738129 SGTC_512 prima-1 270 µM -0.281158061827121 0.38970253798832 no 2060 0.389294584756106 3053 322968 A re-activator of the apoptotic function of mutant p53. SGTC_832 4083-0019 164 µM -0.281746231617171 0.389479792760152 no 2061 0.389069051085554 3025 1990758 SGTC_662 k832-1615 104 µM -0.284792295747286 0.388326803067212 no 2062 0.38790163751132 3001 5878478 SGTC_2100 5377183 190 µM -0.284907494450748 0.38828321753603 no 2063 0.387857507052138 2992 2844202 SGTC_139 0099-0334 718.624 µM -0.286760764502574 0.387582224907839 no 2064 0.387147753561199 2885 97690 SGTC_2418 pentamidine 31.67 µM -0.287533897366288 0.387289898373027 no 2065 0.386851775432063 2973 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2770 toltrazuril 17.5 µM -0.287752063645675 0.387207419845239 no 2066 0.386768266821723 2925 68591 Kills coccidiodes. SGTC_1134 3477-0009 42.5 µM -0.287777481097897 0.387197811019294 no 2067 0.38675853799585 3164 3973534 SGTC_1219 1469-0211 33.1 µM -0.288179350665533 0.38704589724245 no 2068 0.386604727199188 3019 6822282 SGTC_1885 st057546 99.9 µM -0.288185051318374 0.387043742419632 no 2069 0.386602545470195 3076 702008 SGTC_1436 4092-1007 8.32 µM -0.288750508055335 0.38683001945802 no 2070 0.386386154154969 2935 2881121 SGTC_2451 5856223 45.7 µM -0.288902264127682 0.386772666783276 no 2071 0.386328085525957 2940 2179896 SGTC_245 methotrexate 289.6 µM -0.288922687763768 0.386764948334221 no 2072 0.38632027072793 3002 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1707 st032323 6.317 µM -0.289661407544431 0.38648580334694 no 2073 0.38603764170536 2938 3132057 YMR211W DML1 SGTC_422 cantharidin 155 µM -0.290741228508074 0.386077869879401 no 2074 0.38562461859372 2875 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_352 k048-0007 5.11 µM -0.291312969777628 0.385861929105976 no 2075 0.385405984477333 3009 6811911 SGTC_428 3448-4153 16.5 µM -0.293465746220576 0.385049165446485 no 2076 0.38458308900978 2861 3834874 SGTC_846 0335-0850 148 µM -0.296094893592186 0.384057236654442 no 2077 0.383578806781505 3009 6819598 SGTC_1180 1193-0155 285 µM -0.297378653899834 0.383573172945341 no 2078 0.383088719334595 3065 2921347 SGTC_2300 7976697 71.57 µM -0.299539144709175 0.38275893350351 no 2079 0.382264354548302 2921 2236109 SGTC_1114 scopoletin 1.73284 µM -0.300837702172327 0.382269785922602 no 2080 0.381769128589079 3072 5280460 A coumarin with genotoxic properties. SGTC_1713 st033146 12.748 µM -0.301659924526635 0.38196016386257 no 2081 0.381455660714963 3085 674619 SGTC_2873 9040596 71.43 µM -0.302190924484004 0.381760246739702 no 2082 0.381253261124078 3049 6463863 SGTC_1062 mesoridazine 14.2 µM -0.302559312048297 0.381621570370049 no 2083 0.381112863066946 2918 4078 A neuroleptic. SGTC_62 0180-0423 3.232 µM -0.30360109421057 0.381229482612132 no 2084 0.380715908924382 2974 30102 YGL099W LSG1 SGTC_1575 cyproterone acetate 48 µM -0.309895873648434 0.378862970131723 no 2085 0.378320070399997 3010 9880 An androgen receptor antagonist and liver toxin. SGTC_2960 9079389 5.97 µM -0.310765196539715 0.378536503891449 no 2086 0.377989564820685 3116 16457355 SGTC_3067 9117431 49.47 µM -0.310790302552797 0.378527076844998 no 2087 0.377980021157014 2981 17150885 SGTC_2033 5192550 145 µM -0.310993937615443 0.378450616671191 no 2088 0.377902615180519 2984 182073 SGTC_566 0958-0068 16.5 µM -0.311356271443476 0.378314580613845 no 2089 0.377764896583285 3127 6815365 SGTC_166 k072-0058 166.424 µM -0.311737041669776 0.378171638973888 no 2090 0.377620187281566 3059 5846229 SGTC_2877 9040724 71.43 µM -0.312727412944174 0.377799930432252 no 2091 0.377243883462892 3153 6463895 SGTC_2324 6149169 200 µM -0.313828709276598 0.377386722075164 no 2092 0.376825569148453 3017 2888231 SGTC_10 0279-0212 42.575 µM -0.314534259647427 0.377122072027163 no 2093 0.37655765017107 2973 39851 YBR002C RER2 SGTC_381 3461-2219 42.7 µM -0.314848827041131 0.377004097236065 no 2094 0.376438218499604 3068 2883159 SGTC_53 0973-0023 39.979 µM -0.318383498207368 0.375679252233791 no 2095 0.375097027031868 3008 674768 SGTC_3349 9149703 23.001 µM -0.318493595452069 0.375638009659216 no 2096 0.375055276009858 2924 4910494 SGTC_866 0495-0101 262 µM -0.318809497995899 0.375519680034768 no 2097 0.374935487733669 2951 635694 SGTC_1220 1838-0075 193 µM -0.319322595003329 0.375327510984694 no 2098 0.374740950259932 2989 5529645 SGTC_131 0141-0277 33.849 µM -0.320084675198819 0.375042147935542 no 2099 0.374452071226371 3150 1547771 SGTC_2860 9025725 38.96 µM -0.321469505287007 0.374523769598997 no 2100 0.373927309053769 2933 40546248 SGTC_1106 tegaserod maleate 11.7 µM -0.323012614548961 0.373946410271805 no 2101 0.373342844351913 3008 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1733 st037357 54.9 µM -0.323502259045669 0.373763267217515 no 2102 0.373157448480658 2905 1272339 YGL099W LSG1 SGTC_570 0987-0065 62.6 µM -0.325395512568544 0.373055396964456 no 2103 0.372440875669886 2916 3104428 SGTC_1991 st073000 8.92 µM -0.326658104495663 0.372583563252815 no 2104 0.371963245543135 3170 4301969 YIL048W NEO1 SGTC_262 fenpropimorph 62.5 µM -0.330425107193027 0.37117696346966 no 2105 0.370539386543854 2996 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_705 1124-0212 310 µM -0.331287868388311 0.370855049493398 no 2106 0.370213527023417 3138 9554485 SGTC_1697 st025554 27.742 µM -0.331874342470878 0.370636275510633 no 2107 0.369992072575316 2964 1269519 SGTC_735 3076-0345 636 µM -0.331899287254948 0.370626971218447 no 2108 0.369982654301897 3150 2888990 SGTC_1772 st048439 82.2 µM -0.334933070811672 0.369495949311683 no 2109 0.368837787281526 3093 2927068 YDL195W SEC31 SGTC_641 4092-0595 30 µM -0.334941669065814 0.369492745403954 no 2110 0.36883454418328 3068 786260 SGTC_755 1995-0008 37.3 µM -0.335542906506851 0.369268732956576 no 2111 0.368607792006065 3116 689533 SGTC_199 4063-0024 41.6 µM -0.336819840605617 0.368793112943282 no 2112 0.368126357742822 3107 306215 SGTC_1854 st056233 32.9 µM -0.33690817166749 0.368760219667522 no 2113 0.368093062497305 3100 5393174 SGTC_527 4476-4215 268 µM -0.338258785596817 0.368257389434833 no 2114 0.367584089671631 3016 4418754 SGTC_524 r073-0010 27.8 µM -0.341084456018239 0.3672061298524 no 2115 0.366520001323676 2979 2772106 SGTC_1449 4112-4002 201 µM -0.341608386646672 0.367011316312662 no 2116 0.366322812443093 3049 2059539 SGTC_2188 6126565 140.678 µM -0.342616626398208 0.366636518109977 no 2117 0.365943446148466 3110 874518 SGTC_2181 6316240 54.2555 µM -0.343115521839735 0.366451108108175 no 2118 0.365755777214104 3093 12779990 SGTC_3186 9110464 49.47 µM -0.343445469944802 0.366328502982634 no 2119 0.365631678652927 3134 17018021 SGTC_604 1000-0114 314 µM -0.343590016988084 0.366274795171147 no 2120 0.365577316713853 3156 1572745 SGTC_1372 2752-0194 270 µM -0.345361011164485 0.365616978590474 no 2121 0.364911492287837 2985 823334 SGTC_2992 9074591 71.4286 µM -0.346481395397365 0.365201027878637 no 2122 0.364490481839263 3138 17741321 SGTC_2075 5212009 200 µM -0.347309884366932 0.364893547313204 no 2123 0.364179262892866 3148 780898 SGTC_3196 9111891 49.47 µM -0.347386678124152 0.364865050922101 no 2124 0.36415042012148 2995 18891510 SGTC_2171 5739187 198.077 µM -0.349066904240227 0.364241744876146 no 2125 0.363519541130577 2948 2262761 SGTC_2792 7535235 81.82 µM -0.349276779611965 0.364163913519081 no 2126 0.363440764619928 3087 1281891 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.349757624417233 0.363985615465823 no 2127 0.363260301779033 3010 16623 A steroid. SGTC_2641 levomentholum 100 µM -0.351172132144302 0.363461284467902 no 2128 0.362729607859832 3071 16666 SGTC_481 bay k-8644 50 µM -0.351728426581157 0.363255146740958 no 2129 0.362520969895295 3029 2303 A calcium channel antagonist. SGTC_2598 perillyl alcohol 100 µM -0.352255488013026 0.363059877982742 no 2130 0.362323333412379 3184 10819 An apoptosis inducer. SGTC_2057 5236571 38.335 µM -0.35230855719941 0.363040218576085 no 2131 0.362303435663161 3192 54684039 YBR257W POP4 SGTC_1747 st037496 66.6 µM -0.352463310164823 0.362982892614939 no 2132 0.362245414744228 3036 723305 SGTC_1308 1187-1617 41.4 µM -0.352583262688364 0.362938460077875 no 2133 0.362200443594821 3009 2882570 SGTC_1162 k048-0130 20.1 µM -0.35433287155024 0.362290583996282 no 2134 0.361544717877931 3014 6797406 SGTC_590 k048-0076 22.4 µM -0.356312950575033 0.361557840968272 no 2135 0.360803105894581 3145 6832814 SGTC_80 0159-0065 512.242 µM -0.356452905475449 0.361506068781611 no 2136 0.360750707429361 3100 1548079 SGTC_1502 4534-4282 27.7 µM -0.357016247659131 0.361297702612349 no 2137 0.360539821175688 3071 3278949 SGTC_2964 9083345 53.42 µM -0.357673300074059 0.36105472735056 no 2138 0.360293908228056 3087 17741579 SGTC_2112 5488546 200 µM -0.358141520193597 0.360881615687642 no 2139 0.360118704207266 3009 600757 SGTC_1285 0929-0069 65.5 µM -0.358582129266644 0.360718738483006 no 2140 0.359953858836494 3065 1206237 SGTC_631 k072-0230 41.5 µM -0.359491351933079 0.360382711696087 no 2141 0.359613773094553 3141 5773147 SGTC_3029 9088683 49.47 µM -0.359709825796474 0.360301985076345 no 2142 0.359532071659848 3171 25236615 SGTC_1692 fluoroquinolonic acid 71 µM -0.360102005168068 0.360157089477773 no 2143 0.359385426668223 3150 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1811 st050069 61.5 µM -0.360404976934354 0.360045166502075 no 2144 0.359272152653191 3109 3877702 SGTC_645 0845-0943 5.41 µM -0.360783395956848 0.359905388864445 no 2145 0.359130688056639 3092 1885106 SGTC_712 r015-0009 80.6 µM -0.361526920745642 0.359630805719123 no 2146 0.358852792032849 3143 6813872 YLR060W FRS1 SGTC_2689 tacrolimus 100 µM -0.364003620487199 0.358716685666493 no 2147 0.357927652911542 3108 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1146 3579-1023 7 µM -0.36637137732154 0.357843531086108 no 2148 0.357043987398427 3170 X1146 SGTC_3087 9117406 49.47 µM -0.369340620728517 0.35674961791024 no 2149 0.355936925789224 3158 42546093 SGTC_633 0437-0093 97.7 µM -0.36941723075238 0.356721409183371 no 2150 0.355908378299712 3069 2831118 SGTC_3325 9138760 55.175 µM -0.369779206289345 0.356588136062199 no 2151 0.355773504884614 3065 43844959 SGTC_1813 st051246 8.6015 µM -0.371205848506608 0.35606304173561 no 2152 0.355242108675499 3149 5291959 SGTC_1367 1812-0510 76.9 µM -0.371313065476752 0.356023590139908 no 2153 0.355202183814447 3114 1142582 YDR527W RBA50 SGTC_2627 acetyl isogambogic acid 100 µM -0.372520006208122 0.355579590220087 no 2154 0.354752859659695 3150 6857789 A caspase activator and apoptosis inducer. SGTC_3150 9097574 49.47 µM -0.373073700530091 0.355375966992795 no 2155 0.354546795932158 3232 17217476 SGTC_580 1123-0028 41 µM -0.37467946207104 0.354785675603571 no 2156 0.353949434150826 3060 1677248 YPR107C YTH1 SGTC_1721 st082152 9.2685 µM -0.375561909374042 0.354461428863475 no 2157 0.353621306488129 3029 5296051 SGTC_758 0868-0029 16 µM -0.376012647010183 0.354295850342804 no 2158 0.35345374693109 3170 762687 SGTC_1223 0764-0573 147 µM -0.377683073420983 0.353682459375483 no 2159 0.352833021762824 3064 1609797 SGTC_547 1120-0019 610 nM -0.378345211983109 0.353439422969314 no 2160 0.352587081432346 3051 3676939 SGTC_333 3486-0131 40.1 µM -0.378864407662444 0.353248895196999 no 2161 0.352394277939247 3205 6744690 SGTC_2374 9071832 200 µM -0.379120934531575 0.353154771827306 no 2162 0.352299030592861 3139 17381698 SGTC_1453 4237-0541 195 µM -0.380990621227491 0.35246902874358 no 2163 0.351605103918386 3209 739892 SGTC_2601 securinine 100 µM -0.381193453876615 0.352394664795422 no 2164 0.351529853072447 3056 442872 A GABA receptor antagonist. SGTC_525 k781-2675 26.7 µM -0.381261196881686 0.3523698296299 no 2165 0.351504721735834 3166 3651118 YDL195W SEC31 SGTC_2525 harmine 47.85 µM -0.381818327430973 0.352165604685267 no 2166 0.351298061772681 3086 5280953 A monoamine oxidase inhibitor SGTC_306 1672-3436 11.6 µM -0.382309035537772 0.351985763233542 no 2167 0.351116076713059 3177 6797378 SGTC_2490 carminic acid 95.39 µM -0.382424715188102 0.351943372185796 no 2168 0.351073180481128 3117 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2684 capsaicin 100 µM -0.383015350587696 0.351726961312699 no 2169 0.350854191142083 3189 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_249 wiskostatin 11.211 µM -0.383592418316366 0.351515568073583 no 2170 0.350640280116263 3188 2775510 A n-wasp and actin depolymerizer. SGTC_634 1611-4317 11.2 µM -0.386235389162989 0.350547974367853 no 2171 0.349661173297796 3206 2843522 SGTC_329 k048-0121 21.3 µM -0.387122632551076 0.350223370764754 no 2172 0.349332711529157 3159 6832902 SGTC_233 rapamycin 362 pM -0.389767557264623 0.349256358205582 no 2173 0.348354217872969 3153 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1029 k015-0030 64.7 µM -0.389850357728383 0.349226101229179 no 2174 0.348323601968825 3198 2208316 SGTC_3163 9099914 49.47 µM -0.390615629605482 0.348946500673128 no 2175 0.348040685492612 3170 16268368 SGTC_2994 9053520 71.4286 µM -0.391037968171161 0.348792229703266 no 2176 0.347884585629929 3198 4647384 SGTC_954 1189-0853 2.85 µM -0.391313721718439 0.348691516496385 no 2177 0.347782678723401 3124 2828194 SGTC_2612 dictamnine 15.46 µM -0.391991031118101 0.348444188694931 no 2178 0.34753242035873 3154 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1 0258-0098 57.368 µM -0.392089752320976 0.348408144818325 no 2179 0.34749594950634 3129 6790032 YDR047W HEM12 SGTC_334 1502-1024 68.5 µM -0.392142601058639 0.348388849896945 no 2180 0.34747642602826 3190 3296216 SGTC_2286 7945697 125 µM -0.392635682989549 0.348208846020973 no 2181 0.34729429029659 3147 1245733 SGTC_3253 9135987 49.47 µM -0.393991206196923 0.34771417669322 no 2182 0.346793765841482 3193 4182430 SGTC_2586 curcumin 80 µM -0.394050083803335 0.347692696431157 no 2183 0.346772031443761 3197 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3020 9089140 49.47 µM -0.395449271573502 0.347182376072929 no 2184 0.346255676230213 3213 17217859 SGTC_3247 9135149 49.47 µM -0.396199572396436 0.346908835768103 no 2185 0.345978903366324 3114 8934436 YOR116C RPO31 SGTC_2722 naftopidil 47.16 µM -0.396269479841614 0.346883353378969 no 2186 0.345953119918672 3212 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1486 3970-0793 4.53 µM -0.3976912889127 0.346365231505324 no 2187 0.34542887969755 3189 2844330 SGTC_1561 5-methoxyflavone 52.9 µM -0.398312644544263 0.346138893283491 no 2188 0.345199870477691 3146 94525 SGTC_2917 7979103 53.79 µM -0.399530395574969 0.345695468419635 no 2189 0.344751215914628 3240 2980565 SGTC_12 0849-0099 9.267 µM -0.400808359473741 0.345230345540728 no 2190 0.344280611888951 3177 6071388 SGTC_1929 genistein trimethyl ether 50.5 µM -0.403380627274225 0.344294861832062 no 2191 0.343334118064218 3295 136420 SGTC_1573 oleylamine 1.06 µM -0.403815658631075 0.344136743347024 no 2192 0.343174140458225 3108 5356789 An amine of the fatty acid oleic acid. SGTC_1821 st053465 65.6 µM -0.405521077070605 0.343517147155851 no 2193 0.342547264366549 3177 675086 SGTC_1017 4239-0030 168 µM -0.407421018935798 0.342827373460427 no 2194 0.341849395962417 3143 1149593 SGTC_1660 st012960 28.1 µM -0.408033040722595 0.342605290401715 no 2195 0.341624708884456 3202 24207266 SGTC_3050 9093513 49.47 µM -0.412601270870257 0.340949349146026 no 2196 0.339949384995439 3152 25236664 SGTC_1454 4239-0054 42.6 µM -0.413079954198648 0.340776007408588 no 2197 0.3397740177988 3309 1340767 SGTC_2368 9071271 200 µM -0.413412101879349 0.34065574919712 no 2198 0.339652354788207 3155 27209959 SGTC_3069 9117009 49.47 µM -0.414599332905747 0.340226029868764 no 2199 0.339217618306962 3145 41904981 SGTC_3092 9117248 49.47 µM -0.414726436722225 0.340180036811273 no 2200 0.339171088504646 3182 17141857 SGTC_2430 5571206 200 µM -0.414749502073492 0.340171690770533 no 2201 0.339162645069602 3283 1731771 SGTC_351 caspofungin 25 nM -0.415226167944042 0.339999229997778 no 2202 0.33898817210975 3158 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1043 0916-0009 19.3 µM -0.416573695243028 0.339511867150972 no 2203 0.338495126546953 3311 3101130 SGTC_274 sirtinol 40.1 µM -0.417273889657764 0.339258732318413 no 2204 0.338239042228968 3168 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2738 aclarubicin 5.55 µM -0.417346710143274 0.339232410361324 no 2205 0.338212413655404 3170 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_445 e6 berbamine 66 µM -0.417463264496084 0.339190281834614 no 2206 0.338169794418726 3224 6610268 A calcium/calmodulin antagonist. SGTC_569 4130-2812 160 µM -0.420769385411568 0.337996124703908 no 2207 0.336961744505293 3193 743552 SGTC_1624 st003710 6.25 µM -0.421224521453627 0.337831858709393 no 2208 0.336795569977202 3246 24207033 SGTC_2107 5363541 170.161 µM -0.421599008181343 0.337696723519794 no 2209 0.336658865173095 3244 244052 SGTC_769 0302-0231 76 µM -0.421700021565796 0.337660275976096 no 2210 0.33662199435734 3249 571869 YER009W NTF2 SGTC_1755 st041960 45.185 µM -0.422821885199724 0.337255588735316 no 2211 0.336212609449835 3258 2257073 SGTC_2000 st075254 36.4 µM -0.422877233005292 0.337235628119435 no 2212 0.336192417225351 3205 17234175 SGTC_459 nigericin 15.3 µM -0.425122205489588 0.336426388632117 no 2213 0.335373795619596 3283 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2763 lisinopril 49.32 µM -0.425128879449166 0.336423984013962 no 2214 0.3353713631454 3231 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1945 st075991 56.6 µM -0.425656193422643 0.3362340146931 no 2215 0.335179193567872 3167 1084980 SGTC_2316 5844804 197.44 µM -0.426320092444764 0.335994898913398 no 2216 0.334937309496951 3246 776813 SGTC_2032 5185112 25.99 µM -0.426580167411363 0.335901246083272 no 2217 0.334842572790732 3172 5718189 SGTC_674 0498-0004 451 µM -0.429187774183661 0.334962812557368 no 2218 0.333893289733294 3221 4231473 SGTC_2227 7312221 64.1025 µM -0.430180633197055 0.334605769697656 no 2219 0.333532124396787 3199 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3021 9087658 49.47 µM -0.430618438982975 0.334448377472768 no 2220 0.333372915846332 3284 25237042 SGTC_2023 5144124 124 µM -0.431041812382666 0.334296201395411 no 2221 0.333218984193155 3134 2830192 SGTC_1325 1431-0015 227 µM -0.431550749641904 0.334113306539318 no 2222 0.333033980097564 3150 1103340 SGTC_3117 9124945 49.47 µM -0.433269408230434 0.333495969993442 no 2223 0.33240952994683 3112 17592065 SGTC_1998 st075797 76.8 µM -0.433485582744952 0.333418352686134 no 2224 0.332331018890686 3283 24208315 SGTC_438 sphingosine 6.67 µM -0.433891849559038 0.333272502169836 no 2225 0.332183489320539 3113 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3075 9116269 49.47 µM -0.435525755208838 0.332686181842547 no 2226 0.331590424301617 3345 17015205 YNL244C SUI1 SGTC_704 1310-0270 142 µM -0.435747893243993 0.332606500073007 no 2227 0.331509826553313 3204 5718033 SGTC_210 3551-0445 56.827 µM -0.436305940418063 0.332406359768042 no 2228 0.33130738621443 3291 2865180 YOR207C RET1 SGTC_3164 9100705 49.47 µM -0.436357900589979 0.332387726991397 no 2229 0.331288539356825 3298 17174235 SGTC_1101 ebselen 5.29 µM -0.437920602627283 0.331827540021552 no 2230 0.33072192002888 3314 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_586 0957-0265 8.15 µM -0.439401016971157 0.33129719756233 no 2231 0.330185494882788 3236 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1334 1486-0610 236 µM -0.439529672336051 0.331251124122939 no 2232 0.330138893332387 3266 3742339 SGTC_1323 1348-1351 11.2 µM -0.44151567016423 0.330540232565903 no 2233 0.329419859814902 3184 6989654 SGTC_545 4218-0007 221 µM -0.442101358227925 0.330330700993627 no 2234 0.329207930794959 3291 2840508 SGTC_2966 9084041 48.03 µM -0.443306531173366 0.32989971432115 no 2235 0.328772016180565 3056 17741380 SGTC_2138 5575593 77.673 µM -0.443833088789974 0.329711480780581 no 2236 0.328581631791614 3182 762213 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.444884657697127 0.32933569557377 no 2237 0.328201555290591 3222 364106 SGTC_48 0382-0018 55 µM -0.445504059773544 0.329114428704543 no 2238 0.327977763286954 3428 762596 SGTC_2827 7993847 71.43 µM -0.445762495537838 0.329022126278804 no 2239 0.327884407848734 3256 2985692 SGTC_385 1494-0393 12.4 µM -0.447239294160244 0.328494875815147 no 2240 0.327351146414098 3205 3090647 SGTC_2828 7998861 71.43 µM -0.447329577363671 0.328462653733157 no 2241 0.327318557205211 3270 2988188 SGTC_3097 9117246 49.47 µM -0.448189828491605 0.32815569406079 no 2242 0.327008101441841 3273 16423892 SGTC_1770 st043884 66.3 µM -0.448440674772589 0.328066207508816 no 2243 0.326917596133251 3212 670149 SGTC_1290 0986-0249 10.2 µM -0.449159462621091 0.327809842799962 no 2244 0.326658313958025 3230 53329 SGTC_2774 tamoxifen 10.92 µM -0.449536534387183 0.327675387856898 no 2245 0.326522329557042 3282 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2132 5317594 122.667 µM -0.449694428181201 0.327619093270454 no 2246 0.326465394740574 3143 794577 SGTC_1150 3909-7983 10.9 µM -0.450007601454478 0.327507447785421 no 2247 0.326352479763314 3208 23965914 SGTC_1563 conessine 56.1 µM -0.450034402771804 0.327497893899464 no 2248 0.326342817257111 3273 441082 An anti-amoebic, histamine inhibitor. SGTC_2377 9073351 62.6 µM -0.45061618073361 0.327290534916898 no 2249 0.326133101329904 3172 7337946 YHR072W ERG7 SGTC_213 1246-0773 967 nM -0.452065590036258 0.32677416411691 no 2250 0.325610865913962 3237 6251622 SGTC_2347 9049783 174.81 µM -0.453924087324035 0.326112535696777 no 2251 0.324941732996736 3317 6467988 YPL169C MEX67 SGTC_3318 9139014 38.6185 µM -0.454196490239431 0.326015605676634 no 2252 0.32484370448541 3202 16643984 SGTC_2156 5649887 115 µM -0.455855682441393 0.325425463952307 no 2253 0.324246879959463 3295 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_795 0685-0265 78 µM -0.456187059208706 0.32530765217505 no 2254 0.324127735140925 3309 302754 SGTC_1622 st003707 19.4 µM -0.456400688011041 0.325231711659839 no 2255 0.324050935546737 3300 10140899 SGTC_1244 0416-0015 52.5 µM -0.457158773814754 0.324962286802169 no 2256 0.323778464008093 3203 96201 SGTC_986 1493-0483 84 µM -0.457269604567121 0.324922905047308 no 2257 0.323738637077034 3308 40079 SGTC_2790 5423970 71.43 µM -0.459343519406565 0.324186337177784 no 2258 0.322993750322289 3335 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1738 st035555 74 µM -0.46081333878835 0.323664734886139 no 2259 0.322466265486265 3288 5331140 SGTC_323 4013-0906 34.3 µM -0.461254002556174 0.323508421701189 no 2260 0.322308190804448 3286 2910086 SGTC_1546 5-methoxyflavanone 78.7 µM -0.461342668142241 0.323476973819052 no 2261 0.322276388612319 3288 147795 SGTC_2533 agelasine 13.65 µM -0.461486855888919 0.323425836046958 no 2262 0.32222467474762 3410 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1695 st026914 34.495 µM -0.462102229738628 0.323207624436773 no 2263 0.322004005641238 3200 3289191 SGTC_818 4072-2707 53.5 µM -0.462276342819504 0.323145894960714 no 2264 0.321941581194341 3160 882871 SGTC_2293 7624732 200 µM -0.464064648792615 0.322512157002232 no 2265 0.321300714176436 3232 894453 SGTC_945 3381-0768 11.3 µM -0.467664932079454 0.32123785699918 no 2266 0.320012111318481 3359 1126236 YIL048W NEO1 SGTC_1802 st050112 57.9 µM -0.468551539948513 0.320924369076372 no 2267 0.319695111380345 3271 4662563 SGTC_1039 k821-0043 94 µM -0.468902784539415 0.320800210854778 no 2268 0.319569562934414 3338 15992768 SGTC_186 3455-3465 67.277 µM -0.470202937653305 0.320340806154561 no 2269 0.319105017771028 3209 755278 SGTC_2049 5262831 67.185 µM -0.471501684415085 0.319882173111436 no 2270 0.31864125854331 3275 763417 SGTC_1281 0884-0031 11.8 µM -0.473328007349751 0.319237700088127 no 2271 0.317989591758762 3255 1548255 SGTC_1434 4073-0095 163 µM -0.476322325266261 0.318182246560138 no 2272 0.316922381324822 3330 24133745 SGTC_1831 st055328 12 µM -0.476885021182941 0.317984068765686 no 2273 0.316721999374743 3342 1103068 SGTC_1458 k015-0034 6.33 µM -0.477449810774692 0.317785205993173 no 2274 0.316520925908917 3277 3598957 SGTC_405 ebelactone b 50 µM -0.478148689179772 0.317539203209128 no 2275 0.316272189892011 3272 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_101 0490-5701 117.494 µM -0.478723105193212 0.317337071061484 no 2276 0.316067813184127 3310 4661669 SGTC_2242 6630449 61.2675 µM -0.478938330421589 0.317261349143671 no 2277 0.315991250707857 3345 691249 YDR170C SEC7 SGTC_1625 st003711 30.1 µM -0.479538268915572 0.317050315326351 no 2278 0.315777875123181 3431 24207034 YER133W GLC7 SGTC_1514 1189-1591 158 µM -0.479774093070865 0.31696737832137 no 2279 0.315694018132033 3398 767698 YMR146C TIF34 SGTC_1210 3013-0140 750 nM -0.480069909291737 0.316863355706926 no 2280 0.315588841906004 3340 905973 SGTC_1687 st020778 55.3625 µM -0.480499127591527 0.316712448515782 no 2281 0.315436261684805 3287 4259299 SGTC_285 1486-1325 46 µM -0.480513303460402 0.316707464997352 no 2282 0.31543122292743 3350 22310230 SGTC_1472 k841-0093 193 µM -0.482063826367742 0.31616258054675 no 2283 0.314880302953315 3378 X1472 SGTC_349 k015-0014 24 µM -0.482106660500539 0.316147533442864 no 2284 0.314865089294117 3191 2196908 SGTC_2862 9027634 71.43 µM -0.482434624347642 0.316032333870798 no 2285 0.314748614795023 3192 5012562 SGTC_1446 4239-0190 62 µM -0.482635047793123 0.315961942539604 no 2286 0.314677444616673 3236 1340085 SGTC_998 3996-0085 177 µM -0.482757643734635 0.315918888532808 no 2287 0.314633914305471 3252 715391 SGTC_1282 0886-0010 32.4 µM -0.483694589960199 0.315589928416404 no 2288 0.314301316626151 3415 2836211 YNL267W PIK1 SGTC_1959 st077091 55.8 µM -0.483893641741489 0.315520060501656 no 2289 0.314230676517766 3221 821356 YKL052C ASK1 SGTC_1167 k781-0610 148 µM -0.484175414662685 0.31542116843437 no 2290 0.314130691709752 3257 4525169 SGTC_2679 rapamycin 1 nM -0.48532139301861 0.315019107907761 no 2291 0.313724191303699 3329 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2167 5876490 200 µM -0.488296131840385 0.313976459662263 no 2292 0.312670050486324 3408 686534 SGTC_2639 lactacystin 53 µM -0.48861953956711 0.313863194259846 no 2293 0.312555538468819 3395 3870 A proteasome inhibitor. SGTC_784 4579-0127 173 µM -0.489634143955175 0.313507968505607 no 2294 0.31219640541239 3420 1948547 SGTC_325 2810-4341 181 µM -0.493049740210451 0.312313397468055 no 2295 0.310988721114297 3371 774970 SGTC_1235 benzylparaben 21.5 µM -0.493226592439746 0.312251598689066 no 2296 0.310926245059417 3337 7180 SGTC_3140 9094243 49.47 µM -0.494052264707852 0.311963147852615 no 2297 0.310634634436996 3389 19291112 SGTC_1272 0839-0021 27 µM -0.495712989292634 0.311383318473587 no 2298 0.310048460682069 3336 5027250 SGTC_1915 st067105 30.6 µM -0.498494888487218 0.31041308758039 no 2299 0.309067635541132 3360 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1572 epiandrosterone 68.9 µM -0.499913244720683 0.309918920354422 no 2300 0.308568082914173 3316 441302 A steroid. SGTC_2265 7929201 200 µM -0.500533512356286 0.30970292171245 no 2301 0.308349732583186 3192 1265108 SGTC_1358 1509-0022 2.48 µM -0.501083084449194 0.309511596589933 no 2302 0.308156325550842 3346 3258434 SGTC_146 3448-8650 53.125 µM -0.501377633502688 0.309409075081866 no 2303 0.308052688895605 3282 2891488 YIL048W NEO1 SGTC_1271 0832-2808 169 µM -0.5056064337366 0.3079388262359 no 2304 0.306566482073854 3407 3663794 SGTC_2458 5808907 16.39 µM -0.505706231599741 0.307904166080827 no 2305 0.306531446495318 3431 2731747 SGTC_2975 9084847 53.72 µM -0.505742617847544 0.307891529433029 no 2306 0.306518672981866 3344 27211724 SGTC_3353 9151644 39.2805 µM -0.5067117615228 0.30755503760266 no 2307 0.306178538414227 3394 4909158 SGTC_342 k048-0088 23.3 µM -0.508042418050089 0.307093290308738 no 2308 0.305711797934462 3265 6820570 SGTC_1293 1000-1278 195 µM -0.508341508213273 0.306989545950411 no 2309 0.305606932599235 3421 678847 SGTC_721 1187-1332 279 µM -0.509640213670432 0.306539247835405 no 2310 0.305151772687491 3293 25730 SGTC_214 4373-3496 70 µM -0.511076532577224 0.306041575166551 no 2311 0.304648733852627 3436 3779166 SGTC_2888 9058547 12.99 µM -0.51182553382639 0.305782194284451 no 2312 0.304386559166863 3287 16476514 SGTC_2 0422-0095 29 µM -0.513214063596192 0.30530160089707 no 2313 0.303900794694188 3306 6790840 SGTC_2764 methyldopa 94.69 µM -0.513701524595993 0.305132961992641 no 2314 0.303730342939466 3465 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_880 0833-0487 87.2 µM -0.513713550268619 0.305128802190184 no 2315 0.303726138430555 3348 76075 SGTC_1977 st070720 65.3 µM -0.514124702231026 0.304986595692125 no 2316 0.303582403921349 3398 682188 SGTC_2149 5554786 194.827 µM -0.51559124098878 0.3044795989938 no 2317 0.303069964576607 3317 745063 YPR165W RHO1 SGTC_2319 6033012 152.6 µM -0.51590595328662 0.304370848791818 no 2318 0.302960047961118 3263 847246 SGTC_2191 5911152 200 µM -0.516163686346834 0.304281800894618 no 2319 0.302870045240758 3336 2875902 SGTC_251 melphalan 456.522 µM -0.516414211770612 0.304195254389008 no 2320 0.302782570967264 3368 460612 A DNA alkylator. SGTC_2739 tacrine 100.86 µM -0.51644032547654 0.304186233780062 no 2321 0.302773453671776 3373 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_891 0929-0073 133 µM -0.519178781369078 0.30324093544036 no 2322 0.301818037173776 3406 5603632 SGTC_2822 7994718 71.43 µM -0.520024312330325 0.302949328871682 no 2323 0.301523314935438 3339 1018011 SGTC_218 alverine citrate 93.75 µM -0.520923559049811 0.302639334618 no 2324 0.301210011451549 3428 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_919 tnp00227 403.569 nM -0.521268532526623 0.302520450821644 no 2325 0.30108985934989 3322 1269246 A methoxyflavone. YNL221C POP1 SGTC_3232 9132874 49.47 µM -0.521594155150762 0.302408254872506 no 2326 0.300976466849319 3333 3784940 SGTC_988 1497-1057 103 µM -0.521741091866853 0.302357632731352 no 2327 0.300925304960148 3440 3533044 SGTC_894 0960-0238 55.9 µM -0.522504330118411 0.302094745639917 no 2328 0.300659616179745 3421 6741907 YDL195W SEC31 SGTC_1200 1643-0193 18.4 µM -0.522671442249739 0.302037199824517 no 2329 0.300601457365295 3425 5403974 SGTC_1853 st056710 91.2 µM -0.523068485504245 0.301900495937669 no 2330 0.300463297675216 3453 269167 SGTC_601 0986-0029 62.9 µM -0.523132206396953 0.301878559119389 no 2331 0.30044112729939 3374 24747981 SGTC_867 0518-0118 155 µM -0.523951289318504 0.301596642044854 no 2332 0.300156210048125 3409 6848158 SGTC_2846 9008642 19.48 µM -0.524171982218021 0.301520702842549 no 2333 0.300079463124203 3397 2992898 SGTC_322 k048-0136 19.3 µM -0.5242533604189 0.301492703226364 no 2334 0.300051165738033 3391 6823282 SGTC_2640 pentamidine 10.38 µM -0.524841363939773 0.301290424945151 no 2335 0.299846737004283 3388 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1901 st060216 58.6 µM -0.524952143049152 0.301252322819021 no 2336 0.299808229952853 3335 688792 SGTC_1888 azatryptophan 97.5 µM -0.525136992164692 0.301188749379756 no 2337 0.299743980997317 3372 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2358 9037157 4 µM -0.525828740938334 0.300950896297114 no 2338 0.299503601677074 3374 2388925 SGTC_3015 9080845 49.47 µM -0.526006316674876 0.300889851759099 no 2339 0.299441909073595 3436 5296973 SGTC_258 haloperidol 50.781 µM -0.526179318116692 0.300830385080013 no 2340 0.29938181119348 3349 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3156 9099931 49.47 µM -0.532880339825344 0.298531100599468 no 2341 0.297058207703394 3302 18111053 SGTC_3104 9120930 49.47 µM -0.533918853513779 0.298175477789348 no 2342 0.296698838711223 3436 17014836 SGTC_635 k038-0028 24.7 µM -0.534017896514974 0.298141572139827 no 2343 0.296664576108317 3350 4035102 SGTC_740 k014-0057 261 µM -0.534151048506788 0.298095992638304 no 2344 0.296618516811588 3400 4012779 SGTC_2416 tofa 880 nM -0.534972643946291 0.297814821062208 no 2345 0.29633438695623 3283 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2155 5570423 76 µM -0.535402233351997 0.297667852437561 no 2346 0.29618587305778 3318 797402 SGTC_2323 6148992 148.28 µM -0.537220950651144 0.297046010449463 no 2347 0.295557500611709 3310 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_922 1866-0035 480 µM -0.537561234664632 0.296929729137779 no 2348 0.295439999537843 3340 3156169 SGTC_2027 5150920 200 µM -0.538188753628965 0.296715348990233 no 2349 0.29522337175527 3362 786715 SGTC_1312 1218-2183 165 µM -0.539288402651886 0.296339845432481 no 2350 0.294843934919985 3447 6744073 SGTC_1131 3454-3128 32.3 µM -0.540304131083067 0.295993192432177 no 2351 0.294493654956035 3426 710982 SGTC_2908 7930301 100 µM -0.542194844377349 0.295348416392876 no 2352 0.293842143292668 3328 2223178 SGTC_1123 mangostin 811.285 nM -0.543700075389653 0.294835561063912 no 2353 0.293323940275727 3383 5281650 An antioxidant. SGTC_1066 ketoconazole 628 nM -0.543890189017758 0.294770815639488 no 2354 0.293258520353787 3467 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_610 4215-0184 155 µM -0.544476573901941 0.294571156698772 no 2355 0.293056782307895 3421 5605015 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.548093447100795 0.293341024622949 no 2356 0.291813869922796 3422 5355888 SGTC_2279 7948423 32.93 µM -0.549151813948141 0.292981514988123 no 2357 0.29145063480655 3499 1247112 SGTC_2388 9080168 200 µM -0.549682221050712 0.292801421440768 no 2358 0.291268676648685 3352 15943073 SGTC_627 1391-0720 175 µM -0.550691635877097 0.29245882846295 no 2359 0.290922539641509 3389 997839 SGTC_197 4544-0043 41.561 µM -0.550851856258479 0.292404467188437 no 2360 0.290867616380363 3431 896523 SGTC_324 1315-0088 19.6 µM -0.551914510442882 0.292044037543256 no 2361 0.290503463153635 3422 6787421 SGTC_876 0720-0963 56.8 µM -0.552139464518433 0.291967764449617 no 2362 0.290426402652637 3488 765861 SGTC_3333 9141820 12.094 µM -0.553915574593965 0.291365881254034 no 2363 0.289818312859003 3338 1939433 SGTC_255 tunicamycin 200.472 nM -0.554460502071547 0.291181333893219 no 2364 0.28963186493272 3402 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_657 3534-0529 86.7 µM -0.554725841528329 0.291091492713328 no 2365 0.289541098943543 3457 1049549 SGTC_2924 9010168 62.78 µM -0.554831746298562 0.291055638075101 no 2366 0.28950487530125 3432 2993929 SGTC_98 0074-0023 107.663 µM -0.555119597034078 0.290958195062033 no 2367 0.289406429659774 3419 3563821 SGTC_416 estradiol valerate 100 µM -0.556151485426175 0.290609006318466 no 2368 0.289053650658633 3457 13791 A steroid. SGTC_2004 4023728 41.89 µM -0.556724544908761 0.290415168973272 no 2369 0.288857822145087 3481 360084 YDR527W RBA50 SGTC_1478 0453-0656 35.7 µM -0.5568012797844 0.290389218000702 no 2370 0.288831604692892 3474 5258496 SGTC_616 4092-0450 108 µM -0.557520753613888 0.290145951929591 no 2371 0.288585841754772 3437 787165 SGTC_2876 9059903 25.97 µM -0.557543367445243 0.290138307365156 no 2372 0.288578118760148 3444 6916095 SGTC_1534 6-azauridine 81.6 µM -0.557768662111796 0.290062152068813 no 2373 0.288501182251058 3398 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.558142039025172 0.289935961862259 no 2374 0.288373698007472 3339 6708514 SGTC_2284 7945075 39.21 µM -0.558548724425499 0.289798543683412 no 2375 0.288234871279555 3456 1245402 SGTC_1493 4348-0038 111 µM -0.559137707638179 0.289599581629674 no 2376 0.288033871006074 3480 800424 SGTC_838 0109-0203 71.4 µM -0.559538708326819 0.289464157901869 no 2377 0.287897060747583 3442 759422 SGTC_987 1497-1013 404 µM -0.560622409115989 0.289098325372999 no 2378 0.287527485843879 3458 1676435 SGTC_2528 xanthyletin 44.79 µM -0.560723395418098 0.28906424579184 no 2379 0.287493057874416 3400 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1845 st056753 3.01 µM -0.560903172285258 0.289003581642815 no 2380 0.287431773668883 3330 5375839 SGTC_617 3770-0098 35 µM -0.561225239999009 0.28889491765652 no 2381 0.287321999334088 3410 5962639 SGTC_1820 st053765 18.6 µM -0.561258782244555 0.288883601781413 no 2382 0.287310567854986 3439 3690829 SGTC_1743 st037606 46.3785 µM -0.561317818578312 0.288863685679404 no 2383 0.287290448299148 3404 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1117 retinoic acid 1.10837 µM -0.562362938259579 0.288511218137874 no 2384 0.286934382402876 3502 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1168 k815-0004 80.5 µM -0.563138716013285 0.288249717521577 no 2385 0.286670214926497 3389 642433 SGTC_1247 0448-0043 5.84 µM -0.563221411881259 0.288221848838422 no 2386 0.2866420621717 3441 3089013 YGL099W LSG1 SGTC_1403 3909-7815 62.9 µM -0.564414838163862 0.287819803236618 no 2387 0.286235921465967 3391 6615483 SGTC_1211 1056-0033 32.3 µM -0.565693093927632 0.287389474022423 no 2388 0.285801215365672 3484 6741922 SGTC_1174 0739-0097 51.1 µM -0.566297426855672 0.287186129270835 no 2389 0.28559580466549 3420 728447 SGTC_3191 9110352 49.47 µM -0.568195100415051 0.286548046914285 no 2390 0.284951249008369 3458 17122424 SGTC_1691 st019933 84.6 µM -0.568681060222116 0.286384753817347 no 2391 0.284786301638336 3456 6176082 SGTC_3009 9080819 71.4286 µM -0.569417813204037 0.286137273016957 no 2392 0.284536315494968 3440 17027216 SGTC_1225 1216-0074 20.6 µM -0.569748447835064 0.286026243424052 no 2393 0.284424162616779 3400 4241466 SGTC_1975 st070967 30.8 µM -0.570577534347265 0.285747920018836 no 2394 0.284143025352161 3501 261391 SGTC_695 3505-6186 243 µM -0.570882062285997 0.285645722692545 no 2395 0.284039795502864 3470 1819379 SGTC_3100 9120536 49.47 µM -0.57130374648197 0.285504237313938 no 2396 0.283896881282569 3398 16421196 SGTC_1708 st033234 31.827 µM -0.571593011092251 0.28540720124669 no 2397 0.283798865676132 3527 674664 SGTC_1545 lovastatin 49.4 µM -0.571899612958231 0.285304366410841 no 2398 0.283694993133704 3468 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_24 0417-1663 219 µM -0.572297845937899 0.28517082468679 no 2399 0.283560104406679 3472 4329390 SGTC_1835 st008666 49.2 µM -0.572989246780095 0.284939044103815 no 2400 0.283325987431729 3366 690455 SGTC_2757 clomiphene 4.22 µM -0.573851759236102 0.284650027232492 no 2401 0.283034059927018 3562 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_714 4296-0578 26.1 µM -0.575089455296634 0.284235535826656 no 2402 0.282615399523135 3462 1589775 SGTC_3297 9117502 71.43 µM -0.575635142894846 0.284052882482954 no 2403 0.282430911006988 3473 7453720 SGTC_319 1348-1596 45.5 µM -0.577497685101592 0.283429872905915 no 2404 0.281801650981227 3533 5380505 SGTC_3216 9129716 49.47 µM -0.57795033938662 0.28327856166861 no 2405 0.281648823821115 3413 8056934 SGTC_105 0111-0055 734.78 µM -0.5780574892139 0.283242749778189 no 2406 0.281612653268867 3450 5179370 SGTC_514 4466-0038 2.65 nM -0.57885171148373 0.282977370497373 no 2407 0.281344617631784 3454 5722064 SGTC_485 niflumic acid 177 µM -0.57966028438381 0.282707318820395 no 2408 0.281071865474204 3499 4488 A COX2 inhibitor. SGTC_2383 9036125 200 µM -0.580062443108426 0.282573049740336 no 2409 0.280936254716049 3432 79580 SGTC_106 0092-0003 11.579 µM -0.580643821330944 0.282378998701461 no 2410 0.280740265799606 3435 1072148 SGTC_2178 5812956 200 µM -0.581534152626403 0.282081950352736 no 2411 0.280440253679235 3466 5403383 SGTC_2773 thioridazine 9.09 µM -0.582362181258082 0.281805823646627 no 2412 0.280161374860363 3513 5452 An antipsychotic. SGTC_168 3970-0862 530.542 µM -0.582717433442165 0.281687395932459 no 2413 0.280041767657451 3470 3135186 SGTC_1080 nisoldipine 24.4 µM -0.583042008585274 0.281579215770571 no 2414 0.279932510520953 3410 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1491 4138-0063 26.5 µM -0.583885367279493 0.281298219934121 no 2415 0.27964871928747 3481 23883227 SGTC_1241 0364-0022 50.8 µM -0.584534215370585 0.281082124607562 no 2416 0.279430476196376 3432 4563895 SGTC_745 0469-0705 296 µM -0.584672797980295 0.281035980818917 no 2417 0.279383874010648 3598 3486736 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.585179276036134 0.280867370189154 no 2418 0.27921358905848 3402 88881 An O-methylated flavonoid and antioxidant. SGTC_444 curcumin 90.4 µM -0.585360605720321 0.280807015965516 no 2419 0.279152635767571 3478 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_152 4469-0003 551.229 µM -0.586244498013208 0.280512908872767 no 2420 0.278855611351292 3509 697280 SGTC_1709 st033179 39.1045 µM -0.587525799441805 0.280086832403831 no 2421 0.278425314245187 3468 573381 SGTC_1275 0867-0008 21.1 µM -0.593919808493079 0.277965306829756 no 2422 0.276282874797965 3425 3422836 SGTC_3062 9077494 49.47 µM -0.594089397695552 0.277909144237017 no 2423 0.276226160871999 3480 16459633 SGTC_2930 9013230 14.89 µM -0.594665445814384 0.277718416645602 no 2424 0.276033561855106 3508 2995857 SGTC_376 3970-0862 59.1 µM -0.595212880655568 0.27753722207854 no 2425 0.275850590685403 3501 3135186 SGTC_406 estrone 100 µM -0.596076219186769 0.277251584511951 no 2426 0.27556215500433 3544 5870 A steroid. SGTC_1020 4335-0961 93.3 µM -0.596530994378278 0.27710117892252 no 2427 0.275410277291261 3396 669075 SGTC_2889 9059656 51.95 µM -0.596565878765687 0.277089643427648 no 2428 0.275398628926281 3519 3949838 SGTC_3338 9144300 39.5675 µM -0.597024964556205 0.27693785581781 no 2429 0.275245356611654 3456 4901274 SGTC_346 4513-0042 7.16 µM -0.599021271104342 0.276278290467842 no 2430 0.274579350024103 3516 2827372 SGTC_1852 st056254 31.4 µM -0.599134303124724 0.276240968567633 no 2431 0.274541664143152 3441 442583 SGTC_2234 tolnaftate 200 µM -0.599336332643603 0.276174266859185 no 2432 0.274474312062036 3466 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3122 9126309 49.47 µM -0.59936794640645 0.276163830030508 no 2433 0.274463773484956 3543 17591206 SGTC_1939 st074455 53.6 µM -0.599786336023443 0.276025722959493 no 2434 0.274324320407208 3558 1644229 SGTC_2464 5717415 7.67 µM -0.600164393164909 0.275900958491886 no 2435 0.274198340604766 3416 5285744 SGTC_47 0149-0135 24.25 µM -0.600569439653919 0.275767317886731 no 2436 0.274063398869661 3433 5239155 SGTC_2752 diclazuril 33.15 µM -0.601221061769859 0.275552389162949 no 2437 0.273846379041918 3529 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1719 st032227 49.2 µM -0.601722299885092 0.275387118639159 no 2438 0.273679501771131 3518 3125804 SGTC_2626 ethyl orsellinate 100 µM -0.603827140748347 0.274693633802379 no 2439 0.27297928650459 3488 75653 A natural product. SGTC_2789 5281112 71.43 µM -0.60592619209804 0.274002915164807 no 2440 0.272281882941737 3491 765948 SGTC_1822 st052468 42 µM -0.606089204601308 0.273949309837033 no 2441 0.272227759591465 3453 2873678 SGTC_1935 st074532 41.6 µM -0.607897596302554 0.273354982985894 no 2442 0.271627696949496 3589 2829742 SGTC_2855 9016525 58.44 µM -0.609405757165543 0.272859815612663 no 2443 0.27112776139891 3542 43811474 SGTC_647 0140-0236 81 µM -0.609489129003092 0.272832455510669 no 2444 0.271100138117494 3536 990837 SGTC_1006 4099-6547 255 µM -0.609655359293806 0.27277790784569 no 2445 0.2710450658418 3533 3146833 SGTC_2522 biochanin a 4.94 µM -0.60987408409575 0.272706142605181 no 2446 0.270972610580555 3524 5280373 A possible chelator. SGTC_2077 5212015 200 µM -0.610933282430614 0.27235874432122 no 2447 0.270621874959843 3470 780900 SGTC_2871 9038510 12.99 µM -0.611480455723312 0.272179367336021 no 2448 0.27044077663798 3576 4945164 SGTC_2179 6298986 200 µM -0.611525616326922 0.272164565192967 no 2449 0.270425832507833 3517 738374 SGTC_1810 st050138 53 µM -0.611594566046412 0.272141966541202 no 2450 0.270403017099084 3544 3444541 SGTC_3195 9113082 49.47 µM -0.611681617086621 0.272113436413798 no 2451 0.270374213351453 3523 17018038 SGTC_2982 9019404 25.97 µM -0.612776499664968 0.271754726365773 no 2452 0.27001206583685 3434 22333232 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.614119409380064 0.271315078214583 no 2453 0.26956821160963 3538 16486 A toxic proline analog. SGTC_1944 st076371 56.9 µM -0.615891450864844 0.270735481884585 no 2454 0.268983082169421 3436 24208455 SGTC_725 1497-0963 19 µM -0.615994229536095 0.270701884187559 no 2455 0.268949164146296 3570 3549977 SGTC_1976 st070609 63.5 µM -0.616959217702062 0.270386537237258 no 2456 0.268630812841405 3514 682556 SGTC_227 fluconazole 33.516 µM -0.61707414308304 0.270348993193813 no 2457 0.268592911377712 3516 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2835 9006588 71.43 µM -0.617609609217244 0.270174100455403 no 2458 0.268416354406066 3572 2345538 SGTC_1023 4482-3888 16 µM -0.618014102686922 0.270042023241254 no 2459 0.268283021199179 3569 3303168 SGTC_296 1222-0039 74.9 µM -0.618898585474962 0.269753330134929 no 2460 0.267991585214299 3509 5984176 SGTC_1688 st021091 57.6 µM -0.619409437121658 0.269586659800107 no 2461 0.267823332879783 3561 3656366 SGTC_1005 4092-0690 4.4 µM -0.623025546542318 0.268408346109448 no 2462 0.266633867139764 3499 1529343 SGTC_1911 st060208 74.3 µM -0.623929440897561 0.268114216138151 no 2463 0.266336962252298 3528 688783 SGTC_2010 4012422 159 µM -0.624631208894797 0.26788597062033 no 2464 0.266106565840851 3503 952393 SGTC_88 0180-0332 8.668 µM -0.625752717670676 0.267521410407708 no 2465 0.265738574606403 3589 3101745 SGTC_2301 7769476 200 µM -0.625807368406491 0.267503651908482 no 2466 0.265720649114753 3533 977820 SGTC_3085 9117376 49.47 µM -0.625950501098875 0.267457144431514 no 2467 0.265673704365399 3563 16480349 SGTC_2567 aureobasidin a 60 nM -0.628390476521103 0.266664961721976 no 2468 0.264874087135398 3614 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3081 9117243 49.47 µM -0.629107993113162 0.266432232722377 no 2469 0.264639178952701 3595 45595589 SGTC_2775 cyproheptadine 69.59 µM -0.630963249917398 0.265830950445622 no 2470 0.264032276944054 3602 2913 A selective serotonin reuptake inhibitor. SGTC_1473 k844-0725 134 µM -0.632220204666823 0.265423966962274 no 2471 0.263621498262684 3632 54682906 SGTC_1531 st059297 52.4 µM -0.633100355420171 0.265139175409597 no 2472 0.263334055102815 3586 7566702 SGTC_2569 tetrandrine 100 µM -0.63368111413817 0.264951343559868 no 2473 0.263144476272318 3504 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1936 st074407 74.3 µM -0.634571328736491 0.26466355728561 no 2474 0.262854016244177 3561 809813 SGTC_1678 st019265 80.2 µM -0.63582291928839 0.264259215392485 no 2475 0.262445923608185 3611 5367020 SGTC_1621 st003705 32.4 µM -0.636105484414113 0.264167972759261 no 2476 0.262353835548537 3605 24207032 SGTC_1776 st049249 45.9 µM -0.637089643839835 0.263850304806922 no 2477 0.262033226932222 3549 1822314 SGTC_3158 9100007 49.47 µM -0.637867071741553 0.263599503623948 no 2478 0.261780107097311 3555 19297233 SGTC_1420 4'-methoxyflavone 42 µM -0.637926085376094 0.263580470570409 no 2479 0.261760898192661 3578 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3123 9126162 49.47 µM -0.638104429527492 0.263522955348892 no 2480 0.261702851667318 3611 25239884 SGTC_2726 cimetidine 79.27 µM -0.638299374437354 0.263460093781959 no 2481 0.261639409569969 3567 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1999 st074831 12.5 µM -0.638881019498596 0.26327258311371 no 2482 0.261450168228417 3530 17112523 SGTC_2064 5220758 200 µM -0.639050721303777 0.263217887512097 no 2483 0.261394968083202 3630 788518 SGTC_261 5-fluorouridine 15.376 µM -0.639774951855488 0.262984530236916 no 2484 0.261159459620143 3615 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_426 0988-0037 14.6 µM -0.640331779156346 0.262805184582493 no 2485 0.260978462260535 3609 5383008 SGTC_2120 5538279 151.968 µM -0.640337269017261 0.262803416692745 no 2486 0.260976678096039 3576 2058197 SGTC_2496 diffractaic acid 79.83 µM -0.642131627513735 0.26222590881079 no 2487 0.260393860985872 3648 94870 An apoptosis inducer which activates caspases. SGTC_1041 0206-0046 107 µM -0.643326262560153 0.261841780624762 no 2488 0.260006209307317 3528 50494 SGTC_2218 6965428 192.983 µM -0.643794532081332 0.261691289965493 no 2489 0.259854339974434 3557 675684 SGTC_1046 2001-0062 216 µM -0.64385094010013 0.261673164768754 no 2490 0.259836048795198 3534 739778 SGTC_2699 st077704 54.6 µM -0.64418987900947 0.261564269450398 no 2491 0.259726156560312 3578 645852 SGTC_2438 5259590 200 µM -0.644336150915216 0.261517281956564 no 2492 0.259678739062733 3574 1201127 SGTC_2778 tioconazole 65.09 nM -0.645214885308976 0.261235093928537 no 2493 0.259393970611853 3565 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_209 4077-0173 175.592 µM -0.645610910368898 0.261107969540268 no 2494 0.259265684880728 3523 15993494 SGTC_1462 k081-0014 26.5 µM -0.64665870699176 0.260771779340403 no 2495 0.25892642679636 3412 3270634 SGTC_1759 st043059 70 µM -0.647898222487337 0.260374363054891 no 2496 0.258525390243662 3552 669426 SGTC_1683 st010134 710 nM -0.648032825105261 0.26033122524351 no 2497 0.258481859881602 3609 3818134 SGTC_3026 9090633 49.47 µM -0.648503067871244 0.260180549474836 no 2498 0.258329813611825 3575 25236842 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.65169401543572 0.259159290769784 no 2499 0.25729929201396 3579 688664 SGTC_1515 3460-0031 42.1 µM -0.653504577765682 0.258580745468839 no 2500 0.256715519589369 3574 2876596 SGTC_1387 3342-1166 1.8 µM -0.655348477445196 0.257992235707336 no 2501 0.256121707842489 3580 3418228 SGTC_1504 k297-0033 30 µM -0.658351453614336 0.257035277594361 no 2502 0.255156161164304 3510 4388117 SGTC_3052 9092717 49.47 µM -0.659400659159903 0.256701363131848 no 2503 0.254819259481456 3606 25237534 SGTC_3252 9135871 49.47 µM -0.659742624903471 0.256592579792417 no 2504 0.254709504037321 3637 17682838 SGTC_2507 purpurin 79.67 µM -0.661783143412924 0.255943966174979 no 2505 0.25405510533626 3587 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_696 1560-0013 611 µM -0.662227646302867 0.255802786912461 no 2506 0.253912669383088 3667 1650269 SGTC_2315 7733312 200 µM -0.662713297622609 0.255648584914288 no 2507 0.253757095801142 3587 726316 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.663047811188227 0.25554239979136 no 2508 0.253649966815352 3562 279621 SGTC_1651 st011928 86.1 µM -0.663073510133375 0.25553424309129 no 2509 0.253641737632728 3618 720198 SGTC_1730 st033808 45.1 µM -0.664533019797074 0.255071226263735 no 2510 0.253174611253042 3612 1045166 SGTC_1201 1889-3372 45.9 µM -0.666887925242672 0.254325079188612 no 2511 0.252421862149331 3558 5392199 SGTC_2206 7254556 146.969 µM -0.66856661923866 0.253793887713851 no 2512 0.251885986073024 3618 4398905 SGTC_1483 3453-0561 55.9 µM -0.668880306374504 0.253694691887093 no 2513 0.251785916864064 3633 4546991 SGTC_2113 5491891 107.031 µM -0.668895064884458 0.25369002537355 no 2514 0.251781209274716 3639 789979 SGTC_127 0180-0333 59.125 µM -0.670100078859541 0.253309162495504 no 2515 0.251396997315482 3606 771601 SGTC_2142 5622915 118.518 µM -0.67030673521511 0.253243875840781 no 2516 0.251331137237689 3611 5322196 SGTC_502 l-744,832 89.3 µM -0.670807531903573 0.253085701394132 no 2517 0.251171574332618 3601 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1399 3562-5772 25 µM -0.673723543923096 0.252165725060739 no 2518 0.250243545306049 3588 23847490 SGTC_2134 5324836 1.464 µM -0.673747065243563 0.252158311467072 no 2519 0.250236066979076 3593 699272 SGTC_799 1310-0557 151 µM -0.674489052023497 0.251924506558005 no 2520 0.250000221862943 3655 5354492 SGTC_2910 7948405 25.97 µM -0.675087269904989 0.251736087516093 no 2521 0.249810160503304 3594 2971328 SGTC_2105 5350118 200 µM -0.675450851274657 0.251621607659838 no 2522 0.249694683612057 3656 2133313 SGTC_112 phenothiazine 287.218 µM -0.677876061403733 0.250858692529684 no 2523 0.24892513966091 3633 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2868 9035608 32.47 µM -0.67794752292859 0.250836230970257 no 2524 0.248902483349588 3640 6462614 SGTC_2842 9000675 19.48 µM -0.679400960793669 0.250379622137106 no 2525 0.2484419206386 3613 2989072 SGTC_1893 st059353 36.1 µM -0.679427783062655 0.250371199854622 no 2526 0.248433425517613 3617 3112488 SGTC_2987 9018338 71.43 µM -0.68042801776041 0.250057230053021 no 2527 0.248116742788327 3703 5055682 SGTC_2367 9070478 135.38 µM -0.681251659961711 0.249798848863021 no 2528 0.247856132479377 3626 572802 SGTC_1784 st039334 36.3 µM -0.681593722329912 0.249691583648253 no 2529 0.247747942786087 3695 3496984 SGTC_2371 9071574 200 µM -0.681992585126803 0.249566537638692 no 2530 0.247621819738152 3619 45596039 SGTC_810 3825-7150 143 µM -0.682571067719727 0.249385238821038 no 2531 0.247438960682177 3680 22330411 YGL099W LSG1 SGTC_1055 3448-0672 86 µM -0.683475873887427 0.249101809298169 no 2532 0.24715309511394 3623 748378 SGTC_63 0099-0242 26.702 µM -0.683540880561549 0.249081452629915 no 2533 0.247132563628987 3661 3898502 YLR359W ADE13 SGTC_2072 5231554 129 µM -0.685096954729416 0.248594436365695 no 2534 0.246641370891266 3717 789545 SGTC_680 0417-1641 114 µM -0.685634679214745 0.24842625868995 no 2535 0.246471753607222 3635 2835990 SGTC_1179 1021-1431 9.29 µM -0.686030846607755 0.248302392942797 no 2536 0.24634682842629 3645 2840958 SGTC_435 c-PAF 6.7 µM -0.687714978522226 0.247776199756625 no 2537 0.24581614283923 3646 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1076 itraconazole 331 nM -0.687751641688784 0.247764751276574 no 2538 0.245804596764501 3673 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3060 1327-0027 12.5 µM -0.688112863094156 0.247651970990849 no 2539 0.245690855398279 3587 16000455 YPR107C YTH1 SGTC_382 3229-0966 23.2 µM -0.688706734140123 0.247466612613714 no 2540 0.245503918777123 3670 5722370 SGTC_83 0170-0301 39.027 µM -0.690064980162665 0.247042957185424 no 2541 0.24507666231214 3615 3089716 SGTC_826 1683-5028 118 µM -0.690421982223963 0.24693166781377 no 2542 0.244964428423188 3690 722377 SGTC_2401 5128683 200 µM -0.692930138247066 0.246150549442511 no 2543 0.244176697507558 3623 708373 SGTC_3177 9107506 49.47 µM -0.693538682559103 0.245961229637971 no 2544 0.243985779469387 3611 8897194 SGTC_507 nimesulide 162 µM -0.695279872276042 0.245419972615753 no 2545 0.243439962781429 3699 4495 A COX2 inhibitor. SGTC_142 0335-0849 62.6745 µM -0.697859783255316 0.244619173369114 no 2546 0.242632443659911 3685 3889043 YPR107C YTH1 SGTC_3168 9103419 49.47 µM -0.698651360268286 0.24437375185877 no 2547 0.242384968996607 3621 16649256 SGTC_2849 9019321 12.99 µM -0.701757707554324 0.243411939538887 no 2548 0.241415138921345 3654 16489627 SGTC_997 3996-0078 137 µM -0.702015039946834 0.243332354047285 no 2549 0.241334892045589 3713 735687 SGTC_3046 9092212 49.47 µM -0.702515593044229 0.243177587691777 no 2550 0.241178840424651 3690 25236637 SGTC_1269 0831-0796 3.05 µM -0.703601445486745 0.242842035258508 no 2551 0.240840505461496 3668 927758 SGTC_1016 4226-1401 38 µM -0.706043337674607 0.242088352717325 no 2552 0.240080593531856 3679 2901613 SGTC_2781 5567276 71.43 µM -0.706895600797112 0.241825603222117 no 2553 0.23981567901275 3696 2853274 SGTC_856 0433-0016 11.3 µM -0.706939241619007 0.241812153087892 no 2554 0.239802118144091 3696 3911780 SGTC_3079 9117512 49.47 µM -0.708631688779473 0.24129085286797 no 2555 0.239276533075031 3711 7185044 SGTC_2478 5763493 32.33 µM -0.709266782667793 0.241095391702098 no 2556 0.239079468829975 3650 1365576 YLR208W SEC13 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.709920689851079 0.240894230400368 no 2557 0.238876659709699 3736 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_172 1112-0046 2.638 µM -0.710134451538995 0.240828490753582 no 2558 0.238810381997356 3641 2802135 YIL048W NEO1 SGTC_2563 tomatine 8.54 µM -0.710232532822286 0.240798330388546 no 2559 0.238779974848925 3668 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_942 3253-1115 227 µM -0.71044769264458 0.24073217513063 no 2560 0.238713278444857 3728 46497897 SGTC_1344 1488-0097 29.1 µM -0.71054693823344 0.240701663392144 no 2561 0.238682517196647 3688 747966 SGTC_67 0335-0847 266 µM -0.710644806524025 0.240671577147013 no 2562 0.238652184967338 3784 4552207 YOR254C SEC63 SGTC_2081 5214970 32.255 µM -0.711195116988747 0.240502441212834 no 2563 0.238481667035234 3641 2063512 SGTC_2643 anethole 100 µM -0.711589218892364 0.240381355202045 no 2564 0.238359592528437 3693 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1288 0973-0013 65.5 µM -0.712140184946859 0.240212129077435 no 2565 0.238188986156622 3720 4315430 SGTC_1992 st073643 23.3 µM -0.712233402430472 0.240183504274513 no 2566 0.238160128026828 3679 3161292 SGTC_475 α-linolenic acid 10 µM -0.712756063069236 0.24002304245062 no 2567 0.237998359014438 3760 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1119 parthenolide 318.541 nM -0.714043494700165 0.23962803803947 no 2568 0.237600142310421 3820 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3116 9124943 49.47 µM -0.71409056893162 0.239613601646868 no 2569 0.237585588667247 3612 41905195 YPL160W CDC60 SGTC_2028 5153890 36.43 µM -0.714733701416745 0.239416417877081 no 2570 0.237386804459314 3672 2830968 YPR165W RHO1 SGTC_3096 9117468 49.47 µM -0.715167962495252 0.239283324006422 no 2571 0.237252631456434 3632 41316311 SGTC_3183 9108214 49.47 µM -0.715338987314806 0.239230918811377 no 2572 0.237199801605525 3613 4974831 SGTC_140 0062-0056 502.533 µM -0.715482817299475 0.239186851476089 no 2573 0.23715537728732 3689 3758964 SGTC_2009 4012297 12.05 µM -0.715499111747097 0.239181859383151 no 2574 0.23715034476044 3697 45595307 SGTC_2649 anisomycin 9.56 µM -0.715591227712971 0.239153639094515 no 2575 0.237121895922798 3682 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2844 9010103 25.97 µM -0.717179793205089 0.238667258742416 no 2576 0.236631582905689 3701 2480525 SGTC_506 n9-isopropylolomoucine 153 µM -0.717523561772329 0.238562076404726 no 2577 0.236525551703494 3695 6610355 SGTC_2291 7917025 104.35 µM -0.719405684748408 0.237986656126884 no 2578 0.23594549761846 3672 2964612 SGTC_984 1492-0255 2.91 µM -0.719809071982765 0.237863427885954 no 2579 0.235821279249857 3662 1585198 SGTC_2674 ligustilide 100 µM -0.720221143285962 0.2377375829396 no 2580 0.235694423960086 3695 5319022 A signalling regulator. SGTC_119 0121-0043 24.815 µM -0.72033140148328 0.237703916716839 no 2581 0.235660487587532 3786 1092378 SGTC_1374 2889-5571 141 µM -0.720906256630099 0.237528432898717 no 2582 0.235483596573629 3729 2853281 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.724105141232755 0.236553221638405 no 2583 0.234500594247148 3766 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_985 1493-0307 8.71 µM -0.724942609081462 0.236298275754045 no 2584 0.23424361973552 3700 3278274 SGTC_69 0096-0274 206.684 µM -0.725431196333706 0.236149607644762 no 2585 0.234093770227851 3821 6741392 SGTC_1667 st014849 34.6 µM -0.725431718882434 0.236149448670387 no 2586 0.234093609990797 3768 5348460 SGTC_2232 chlorophetanol 41.5365 µM -0.726379668782537 0.235861152081599 no 2587 0.233803025737217 3778 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_888 0916-0002 6.97 µM -0.72660296715263 0.23579326939806 no 2588 0.233734605030547 3779 2802138 YIL048W NEO1 SGTC_3330 9141424 71.43 µM -0.727478294482743 0.235527273875489 no 2589 0.233466503616306 3748 27261020 SGTC_1329 1447-1697 50.6 µM -0.728125300614523 0.235330767335573 no 2590 0.233268443717921 3724 2840515 SGTC_39 0986-0283 58.349 µM -0.728637823458084 0.235175169874136 no 2591 0.233111617720427 3756 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1186 1319-0216 26 µM -0.729615347685994 0.23487855963137 no 2592 0.232812669095275 3784 4565136 SGTC_1341 1486-1360 280 µM -0.730210496457495 0.234698074905133 no 2593 0.232630763756814 3708 3976547 SGTC_955 1216-0110 33 µM -0.730289757622384 0.234674043964048 no 2594 0.232606543795827 3673 3619719 SGTC_1655 st012546 55.1 µM -0.731228848243086 0.234389427640364 no 2595 0.232319691093275 3682 720985 YLR208W SEC13 SGTC_1904 st060225 78 µM -0.732131043776228 0.234116173355008 no 2596 0.232044293746209 3703 66595 SGTC_1737 st035557 69.7 µM -0.732549585755698 0.233989466539211 no 2597 0.231916594547355 3645 5716916 SGTC_3035 9091303 49.47 µM -0.733689210114503 0.233644656302479 no 2598 0.231569088039239 3770 25237002 SGTC_1159 4092-0538 61.2 µM -0.733837166016895 0.233599910722957 no 2599 0.231523993032239 3754 717301 SGTC_663 1486-0733 13.9 µM -0.73475577793544 0.233322205777001 no 2600 0.231244121819541 3747 722445 YPR165W RHO1 SGTC_3212 9128307 49.47 µM -0.73502510258862 0.233240821165867 no 2601 0.231162103139488 3711 27243542 SGTC_440 fluspirilene 35.1 µM -0.736595961749372 0.232766452513871 no 2602 0.230684045727122 3829 3396 An atypical antipsychotic. SGTC_2603 homopterocarpin 100 µM -0.737829527248535 0.232394316053238 no 2603 0.230309023927225 3779 101795 A weak amylase inhibitor. SGTC_3284 9108171 64.8615 µM -0.738010156920196 0.232339852301201 no 2604 0.230254138518069 3723 8687505 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.738686938876815 0.232135851063601 no 2605 0.230048559327121 3675 17037758 SGTC_449 xestospongin c 11.1929 µM -0.739495095724661 0.23189238037498 no 2606 0.229803208325039 3732 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1526 st051518 75 µM -0.739614572292574 0.231856398143175 no 2607 0.22976694847542 3740 673993 SGTC_1081 sertraline 6 µM -0.739889695227858 0.231773552407352 no 2608 0.229683463816386 3732 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1410 3909-8106 77.9 µM -0.740733557939357 0.231519549163015 no 2609 0.229427503960708 3748 1039210 SGTC_3090 9117696 49.47 µM -0.741383555275315 0.231324005375546 no 2610 0.229230456260779 3697 7923821 SGTC_2622 2-methoxyxanthone 59.94 µM -0.74170582007923 0.231227090099714 no 2611 0.229132796385364 3763 71034 A hepatoprotective. SGTC_1635 st007035 42.4 µM -0.742827917412114 0.23088981655977 no 2612 0.228792935551114 3735 3716403 SGTC_1260 0700-1617 7.75 µM -0.74298202925977 0.230843515974227 no 2613 0.22874628026716 3765 2853078 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.74434680989369 0.230433714520092 no 2614 0.228333344507771 3802 688788 SGTC_1226 3909-7979 35.4 µM -0.744498931475771 0.230388062314417 no 2615 0.228287343705161 3763 6615510 SGTC_3326 9140064 16.379 µM -0.745429476144381 0.230108912785205 no 2616 0.228006065088029 3712 1868434 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.745753508987309 0.230011752201757 no 2617 0.227908164455971 3767 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1018 4259-0013 28.1 µM -0.747573426875779 0.229466480346799 no 2618 0.227358749002382 3826 6801262 SGTC_2713 st079149 53.4 µM -0.748097416383382 0.229309620463504 no 2619 0.227200700144347 3783 3103253 SGTC_2513 baicalein 25.65 µM -0.748425227012602 0.229211518660035 no 2620 0.227101855432271 3748 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1753 st043925 64 µM -0.748704804176849 0.229127869977725 no 2621 0.227017573711321 3789 670181 SGTC_935 2996-0153 430 µM -0.750563343979267 0.228572235664345 no 2622 0.226457744259419 3734 23738523 SGTC_862 0452-0056 10.2 µM -0.751023013597124 0.228434928364796 no 2623 0.226319402896692 3702 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2630 antimycin a 100 µM -0.751279993990719 0.228358186294915 no 2624 0.226242083336417 3762 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2702 st077768 96.8 µM -0.752030490321381 0.22813414849469 no 2625 0.2260163615027 3710 6484119 SGTC_1231 0242-0792 125 µM -0.752491139562737 0.227996696940626 no 2626 0.225877878141211 3764 3707635 SGTC_3207 9114163 49.47 µM -0.752602942004457 0.227963343618147 no 2627 0.225844274603755 3768 849233 SGTC_593 1203-0218 61.7 µM -0.753354566083138 0.227739187577411 no 2628 0.225618438561741 3780 3666956 SGTC_780 0109-0199 192 µM -0.753385350643564 0.227730009376468 no 2629 0.225609191631792 3776 610414 SGTC_1356 1502-0781 85.8 µM -0.753785119063857 0.227610840132346 no 2630 0.225489130440408 3731 567702 SGTC_2988 9073640 71.4286 µM -0.757083960430185 0.226628811078094 no 2631 0.224499781406943 3778 9102229 SGTC_1735 st034310 56.75 µM -0.759288841493746 0.225973777666132 no 2632 0.223839895522065 3898 871153 SGTC_2256 7954252 200 µM -0.759448716509308 0.225926323119621 no 2633 0.223792090373115 3758 2972920 SGTC_2750 bromebric acid 70.15 µM -0.760254584264826 0.225687209013955 no 2634 0.223551211587173 3835 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_928 2764-0428 58.7 µM -0.761864053334165 0.225210082079971 no 2635 0.22307057309548 3825 662578 SGTC_2467 5474540 200 µM -0.763979441280788 0.224583845412476 no 2636 0.22243974708171 3750 5413519 SGTC_2196 6573537 42.6665 µM -0.765490815256768 0.22413702596055 no 2637 0.221989666807933 3796 2903087 SGTC_490 phenamil 164 µM -0.766932473352533 0.223711288050802 no 2638 0.221560832560499 3746 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_811 0416-0114 265 µM -0.767597999747392 0.223514905811297 no 2639 0.221363025564753 3823 6612453 SGTC_3108 9121785 49.47 µM -0.767626050976676 0.223506630663113 no 2640 0.221354690428928 3689 17140271 SGTC_2063 5246145 200 µM -0.76888622588033 0.223135057282642 no 2641 0.22098042752756 3829 711240 SGTC_206 4546-0025 72.014 µM -0.769269131892645 0.223022223867992 no 2642 0.220866778978142 3795 6620745 YIL048W NEO1 SGTC_2022 5136654 200 µM -0.76953274973918 0.222944560766319 no 2643 0.220788555247283 3823 1713771 SGTC_2589 lobaric acid 100 µM -0.772427725234019 0.222092701020529 no 2644 0.219930569071527 3808 73157 A novel microtubule depolymerizer. SGTC_1369 1866-0067 208 µM -0.772911820654034 0.221950435273883 no 2645 0.219787284278419 3784 3531355 SGTC_1209 2323-2347 50.3 µM -0.773536383872618 0.221766965813133 no 2646 0.219602502369444 3745 5412760 SGTC_1892 st058411 7.36 µM -0.773648344182725 0.221734085912288 no 2647 0.219569387469575 3771 3934738 SGTC_2583 asiatic acid 100 µM -0.774134629574535 0.22159130856058 no 2648 0.219425590391802 3780 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2259 7964009 200 µM -0.776032202161663 0.221034668611878 no 2649 0.218864986254553 3816 313134 SGTC_458 nppb 133 µM -0.777186553970686 0.220696439243591 no 2650 0.21852435700441 3801 4549 A chloride channel blocker. SGTC_2373 9071805 200 µM -0.777358612242577 0.22064605092883 no 2651 0.218473611737964 3768 10149009 SGTC_814 3342-0569 96 µM -0.77755710661016 0.220587928829822 no 2652 0.218415078086392 3835 4346283 SGTC_1626 st003712 1.76 µM -0.780335391882384 0.21977532677228 no 2653 0.217596742979745 3767 24207035 SGTC_2361 9034121 116 µM -0.78034202450296 0.219773388899855 no 2654 0.2175947914819 3796 6496917 SGTC_1012 4112-3522 18 µM -0.78061527550431 0.21969356087126 no 2655 0.217514402365757 3771 3112398 SGTC_2925 9010536 32.5 µM -0.781795910342009 0.219348839559623 no 2656 0.217167262445945 3779 2994177 SGTC_2882 9058044 58.44 µM -0.781999353588959 0.219289469689009 no 2657 0.217107476740446 3771 18076804 SGTC_2798 7813637 45.45 µM -0.782253318981689 0.219215369144345 no 2658 0.217032857478908 3801 956368 SGTC_236 1509-0011 5.31 µM -0.782381775258497 0.219177894401364 no 2659 0.216995120530349 3866 3107280 SGTC_906 1165-0455 526 µM -0.78482249004355 0.218466561111518 no 2660 0.216278825998343 3787 3252859 SGTC_897 1000-0139 31.4 µM -0.784930618228255 0.218435078514093 no 2661 0.216247124521029 3778 6151020 SGTC_1760 st045453 10.4495 µM -0.786032720789635 0.218114339457401 no 2662 0.215924158934392 3865 3323419 YIL048W NEO1 SGTC_2883 9059145 45.46 µM -0.787728299269281 0.217621414704019 no 2663 0.215427824381991 3801 16476510 SGTC_513 4245-1575 41.7 µM -0.788819839406072 0.217304431463658 no 2664 0.215108656132614 3764 719745 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.790926530611038 0.216693402881754 no 2665 0.214493432753838 3768 97141 SGTC_107 0358-0022 2.6945 µM -0.791536297628948 0.216516730543973 no 2666 0.214315551745901 3846 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3268 9137683 49.47 µM -0.7918273460653 0.216432432306403 no 2667 0.214230677465015 3844 1953228 SGTC_2516 gossypol 71.55 µM -0.792578870232707 0.216214851372722 no 2668 0.214011611708388 3860 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_981 1488-1094 54.9 µM -0.794182910994631 0.215750874111171 no 2669 0.213544477776291 3803 3449522 SGTC_2850 9015429 58.44 µM -0.794430705514921 0.21567924973847 no 2670 0.213472367276018 3885 6457570 SGTC_1982 st072467 71.9 µM -0.795692945437356 0.215314616540772 no 2671 0.213105264105508 3811 3163533 SGTC_885 0865-0106 16.8 µM -0.795940420941707 0.215243168305572 no 2672 0.213033332843114 3754 2793380 SGTC_2736 butenafine 14.65 µM -0.796107742773908 0.215194868899399 no 2673 0.212984707084958 3787 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2656 pseudo-anisatin 100 µM -0.797725018122309 0.214728347798942 no 2674 0.212515041135167 3873 6708809 A neurotoxin. SGTC_1618 st003135 44.5 µM -0.798743944831788 0.214434729045234 no 2675 0.21221944993653 3744 1270615 SGTC_1777 st045864 34.765 µM -0.798975248339603 0.214368108058249 no 2676 0.212152382148252 3822 4691462 SGTC_2654 protoveratrine a 100 µM -0.800243681547852 0.214002982779885 no 2677 0.211784812978506 3808 5702278 A heart drug and vasodilator. SGTC_421 streptovitacin 30 mM -0.800276738498742 0.213993472002453 no 2678 0.211775238652673 3931 91467 include heat shock SGTC_929 2805-0021 398 µM -0.80152254381997 0.213635222179531 no 2679 0.211414599179461 3911 3098024 SGTC_1093 fluphenazine 7.97 µM -0.802702986625184 0.213296090935203 no 2680 0.211073213143328 3852 6602611 An atypical antipsychotic. SGTC_3148 9097893 49.47 µM -0.803032890111737 0.213201368601273 no 2681 0.210977862302661 3842 17174100 SGTC_1331 1472-0049 76.2 µM -0.80348451117833 0.213071738338144 no 2682 0.210847372814415 3784 24051409 SGTC_2031 5180455 200 µM -0.805232297566257 0.212570499019064 no 2683 0.210342820996692 3817 29949 SGTC_3215 9129942 49.47 µM -0.805344246810036 0.212538417115603 no 2684 0.210310527610288 3789 17682944 SGTC_1508 1080-0625 72.9 µM -0.807179315629778 0.212012934740724 no 2685 0.209781590441366 3745 767111 SGTC_2287 7945887 168.79 µM -0.808019936582455 0.211772472135539 no 2686 0.209539552686307 3874 1245853 SGTC_27 0485-0001 32.618 µM -0.808456275772077 0.211647718707606 no 2687 0.209413983493386 3778 2054479 SGTC_684 1140-0066 328 µM -0.808465671752208 0.211645032782815 no 2688 0.209411280016052 3879 6813534 SGTC_2044 5102272 200 µM -0.808644484856346 0.211593921263832 no 2689 0.209359834569374 3858 592666 SGTC_3160 9100216 49.47 µM -0.808781148024603 0.211554862655976 no 2690 0.209320520890181 3748 17191039 SGTC_3309 9129340 25.759 µM -0.809069257399001 0.21147253424941 no 2691 0.209237655154628 3881 17158987 SGTC_196 k015-0023 18.111 µM -0.810235869897458 0.211139361904473 no 2692 0.208902312674552 3802 5211998 SGTC_2137 5261020 140 µM -0.81039405409562 0.211094209844685 no 2693 0.208856867053805 3820 763655 SGTC_1698 5-fluorocytosine 1.055 µM -0.811238239248027 0.210853341544232 no 2694 0.208614434900706 3868 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2919 7978188 46.38 µM -0.811828224568154 0.21068509888884 no 2695 0.208445102098209 3808 2980291 SGTC_1301 naphtanilide LB 4.81 µM -0.812426217162062 0.210514653238664 no 2696 0.208273553856572 3898 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_831 k061-1017 217 µM -0.812478113385363 0.210499865091029 no 2697 0.208258670133194 3908 1240153 SGTC_1722 st034304 3.6505 µM -0.812569199259617 0.210473911085849 no 2698 0.208232548420949 3865 4036148 YLR033W RSC58 SGTC_3145 9085516 49.47 µM -0.812977616958793 0.210357559658583 no 2699 0.20811544569125 3915 25236195 SGTC_450 aminopyrene 156 nM -0.813769103068699 0.210132185928549 no 2700 0.207888619130325 3770 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1274 0865-0114 173 µM -0.814057177741149 0.210050192592105 no 2701 0.207806098040787 3871 870624 SGTC_719 2810-4230 27.3 µM -0.814645155398136 0.20988289763212 no 2702 0.20763772760961 3833 721079 SGTC_3293 9120939 62.045 µM -0.814681978820895 0.209872423015683 no 2703 0.207627185715501 3830 934087 SGTC_958 1222-0007 33 µM -0.815033612430533 0.20977241446185 no 2704 0.207526535166834 3934 7312461 SGTC_2729 fluphenazine 10.66 µM -0.815190451366757 0.209727816741125 no 2705 0.207481651361395 3785 3372 An atypical antipsychotic. SGTC_500 h-89 112 µM -0.815803057031094 0.209553673519802 no 2706 0.207306392265977 3876 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2957 9076800 11.52 µM -0.816049105355169 0.2094837541906 no 2707 0.207236025453598 3827 16459615 SGTC_2067 5224629 34.075 µM -0.816782104727547 0.209275539787863 no 2708 0.20702648033385 3842 2835000 SGTC_829 1635-0120 117 µM -0.817985959993718 0.208933839401445 no 2709 0.206682602133338 3884 285054 SGTC_1617 st002906 78 µM -0.818783649295346 0.208707605668782 no 2710 0.206454930635942 3866 5150859 SGTC_2928 9011484 9.79 µM -0.820850365143366 0.208122133644214 no 2711 0.205865753118974 3893 2994751 SGTC_953 1188-0045 9.7 µM -0.822535542041125 0.207645464522016 no 2712 0.205386083489753 3908 6144426 SGTC_2090 5301565 104.445 µM -0.824031425338834 0.207222879897638 no 2713 0.204960851135493 3869 2056344 SGTC_1843 st055809 45.5 µM -0.82580697532938 0.206721950605004 no 2714 0.204456798302962 3924 16413835 SGTC_491 tetrandrine 80.3 µM -0.829111666813506 0.205791521700166 no 2715 0.203520611287832 3873 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2488 5268135 45.7 µM -0.830361883514616 0.20544017469932 no 2716 0.203167104719989 3948 1270356 YLR208W SEC13 SGTC_3182 9108849 49.47 µM -0.830486735358541 0.205405107299206 no 2717 0.203131822223688 3908 17133045 SGTC_2483 5729050 27.16 µM -0.83057458227938 0.205380435680453 no 2718 0.203106999322976 3861 2865180 SGTC_297 0986-0032 24 µM -0.831344581320953 0.2051642584407 no 2719 0.202889498242985 3839 2847425 SGTC_1649 st011737 51.3 µM -0.836435461684614 0.203738399232781 no 2720 0.201454984941546 3873 1761035 SGTC_1477 0139-0234 16 µM -0.836511258822528 0.203717214621439 no 2721 0.201433672773933 3898 620880 SGTC_1867 st057372 64 µM -0.837651204752768 0.203398768516607 no 2722 0.201113312868926 3865 688837 SGTC_1754 st042065 16.137 µM -0.839648916682957 0.202841420635039 no 2723 0.200552631807991 3778 1126236 YIL048W NEO1 SGTC_133 0724-0033 378.92 µM -0.839670502593344 0.202835403301244 no 2724 0.200546578601939 3739 280309 SGTC_521 r062-0005 13.8 µM -0.840831682518994 0.202511867525426 no 2725 0.200221117664877 3799 2832033 SGTC_2731 amoxapine 43.43 µM -0.842822618276475 0.201957858101334 no 2726 0.199663828094306 3972 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_361 000s-0510 1.45 µM -0.845234258253978 0.201287997485291 no 2727 0.198990029207779 3903 660 SGTC_651 3253-0966 34.4 µM -0.845920111974096 0.201097737301838 no 2728 0.198798656008945 3920 781462 SGTC_2996 9066192 71.4286 µM -0.845975629524718 0.201082341100399 no 2729 0.198783169848277 3969 6472854 SGTC_2918 7977171 22.06 µM -0.84659264764667 0.200911276405251 no 2730 0.198611106719847 3817 2236483 SGTC_1877 wortmannin 25 µM -0.848512466604982 0.200379576518297 no 2731 0.198076316304555 3910 312145 A covalent inhibitor of PI 3-kinase. SGTC_442 cape 100 µM -0.848687514572743 0.200331138520397 no 2732 0.198027597721854 3835 5281787 SGTC_930 2810-3379 265 µM -0.8495281749273 0.200098615144747 no 2733 0.197793729661442 3937 1015764 SGTC_3298 9116858 71.43 µM -0.853591497603679 0.19897700498893 no 2734 0.196665685579039 3967 2506942 SGTC_1834 st055981 52.8 µM -0.853851151129127 0.198905461130222 no 2735 0.19659373427452 3962 471719 YDL150W RPC53 SGTC_556 4058-0063 51.5 µM -0.854309200829009 0.198779289816606 no 2736 0.196466845275072 3960 6615692 SGTC_2945 9067681 61.76 µM -0.857027259835874 0.198031584603467 no 2737 0.195714909715449 3999 16456930 SGTC_1969 st069479 40.1 µM -0.857220065292161 0.197978610742162 no 2738 0.195661637619712 3920 3895485 SGTC_2428 5615643 7.78 µM -0.858878169693198 0.197523395107946 no 2739 0.195203867290225 3959 2253075 SGTC_82 0054-0107 293.755 µM -0.859342248313308 0.197396100492388 no 2740 0.195075860889722 3884 3104697 SGTC_1346 1488-2224 62.4 µM -0.861219376004269 0.196881719444552 no 2741 0.194558615215114 3882 3722427 SGTC_2406 ethylparaben 405.7 µM -0.863187731508407 0.19634321220296 no 2742 0.194017128980671 3969 8434 A possible steroid mimic. SGTC_2555 cholic acid 100 µM -0.863843449823552 0.196164017718031 no 2743 0.193836947751401 3937 6708657 Influences liver metabolism. SGTC_870 0573-2213 57.6 µM -0.864512164424979 0.195981373792303 no 2744 0.193653300430281 3906 3916321 SGTC_360 0957-0399 1.01 µM -0.864918463010695 0.195870453131618 no 2745 0.193541771558149 3953 6752301 YPR165W RHO1 SGTC_1060 3448-7350 82 µM -0.865075331432592 0.195827637804984 no 2746 0.193498721696062 3869 570178 SGTC_2568 diosmetin 100 µM -0.866777931167191 0.195363299379615 no 2747 0.193031848081342 3965 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2243 6634756 200 µM -0.867888510636112 0.195060779357392 no 2748 0.192727684638399 3999 885676 SGTC_2294 7971431 200 µM -0.871177296087822 0.194166591273337 no 2749 0.191828677267133 3922 5741572 SGTC_995 3931-2021 34.6 µM -0.87199309410088 0.193945170979724 no 2750 0.19160607249533 3929 730143 SGTC_32 0928-0142 34.1 µM -0.873987139341259 0.193404604100766 no 2751 0.19106262875152 3888 2244242 SGTC_3039 9090270 49.47 µM -0.874537897758549 0.193255460849637 no 2752 0.190912695492227 3923 17173750 SGTC_2475 5812728 15.03 µM -0.875009468522504 0.193127817105956 no 2753 0.190784376904307 3907 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2268 7933382 153.85 µM -0.875673408090594 0.192948190664182 no 2754 0.190603802793605 3949 935025 YOR257W CDC31 SGTC_497 capsazepine 133 µM -0.876631922179493 0.192689048206663 no 2755 0.190343297293955 3925 2733484 A calcium channel blocker. SGTC_2576 guaiol 23.12 µM -0.876777935916765 0.192649590823104 no 2756 0.190303632800802 3897 227829 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.87681080164368 0.192640710178009 no 2757 0.190294705557344 3969 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1045 1348-1485 165 µM -0.878503571710999 0.192183645283565 no 2758 0.189835250132165 3945 6810614 SGTC_1686 st019653 115.5 µM -0.878804535865708 0.192102451459635 no 2759 0.189753633247284 3888 97252 SGTC_762 1165-0429 115 µM -0.879415861242759 0.191937593306618 no 2760 0.189587917584969 3921 5967793 SGTC_2667 digitoxin 100 µM -0.883562725262132 0.190821582199167 no 2761 0.188466154073744 3892 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1400 3771-8998 51.5 µM -0.885946671505776 0.190181816653758 no 2762 0.187823132383644 3866 670767 SGTC_996 3970-0799 1.8 µM -0.886104353525342 0.190139546982819 no 2763 0.187780648647109 3985 6615648 YGL040C HEM2 SGTC_2693 st077581 40.7 µM -0.887918932977898 0.189653529943456 no 2764 0.187292179836009 4012 25238761 SGTC_1758 st042942 75.2445 µM -0.889259751930836 0.189294896355756 no 2765 0.186931748378668 3874 669317 SGTC_1795 st049545 62.3 µM -0.889642595865741 0.189192572405527 no 2766 0.186828913231242 3879 5291882 SGTC_1896 st058441 89 µM -0.895055948279036 0.187749375753618 no 2767 0.185378590395403 3977 688759 SGTC_2334 9017922 200 µM -0.895572094236459 0.187612127520471 no 2768 0.185240672650645 4042 3163164 SGTC_501 nsc-95397 161 µM -0.89627823671538 0.187424457810222 no 2769 0.185052089780393 4018 262093 SGTC_708 3448-5400 146 µM -0.898170091722021 0.186922236406515 no 2770 0.184547437847928 3921 3462195 SGTC_3077 9117319 49.47 µM -0.899066397344057 0.186684589564859 no 2771 0.184308647601522 3930 17154678 SGTC_386 1509-0011 3.07 µM -0.899219229526279 0.186644086251345 no 2772 0.184267949842164 3992 3107280 SGTC_1521 st012942 49.4 µM -0.899253417273632 0.18663502661997 no 2773 0.184258846735021 3985 24207259 SGTC_744 1594-0068 283 µM -0.901387502909525 0.186070040577371 no 2774 0.183691161826793 3971 668392 SGTC_2887 9044784 58.44 µM -0.902577363856325 0.18575549307133 no 2775 0.183375122382793 3956 6465546 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.903781155156853 0.185437598860132 no 2776 0.183055728098438 3993 23665772 A membrane-active detergent. SGTC_1666 st014829 29 µM -0.905046308073314 0.185103864623237 no 2777 0.182720427434996 3967 3858230 SGTC_2121 5257820 149.641 µM -0.90624018750086 0.184789273985946 no 2778 0.182404368115187 4028 791256 SGTC_3343 9148379 18.9835 µM -0.907629281332912 0.184423662367401 no 2779 0.182037059267704 4027 1955036 SGTC_1494 4358-1428 177 µM -0.908505942466823 0.184193155594455 no 2780 0.181805487788196 3996 1564571 SGTC_3146 9095609 49.47 µM -0.908983678684571 0.184067616515502 no 2781 0.181679370588087 4030 17173999 SGTC_3184 9108758 49.47 µM -0.9096689514864 0.183887634194758 no 2782 0.181498561574688 3999 902885 SGTC_1849 st056239 19.2 µM -0.909744033244859 0.183867921137137 no 2783 0.18147875812502 3996 5393181 SGTC_3206 9114350 49.47 µM -0.910464865857426 0.183678730233098 no 2784 0.181288701252055 3903 17087243 SGTC_2337 9009472 200 µM -0.910560508406798 0.183653636850922 no 2785 0.181263493222216 3929 5742383 SGTC_2534 helenine 20.12 µM -0.91080789373391 0.183588741185639 no 2786 0.181198301287595 3973 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_108 0509-0257 621.132 µM -0.912208083495173 0.183221704053423 no 2787 0.180829594727898 3955 536624 SGTC_1636 st007707 68.9 µM -0.91451849188073 0.182617069215556 no 2788 0.180222232866658 4028 403051 SGTC_1464 k208-0027 110 µM -0.915669166513243 0.182316402537211 no 2789 0.179920220856286 3949 X1464 SGTC_2651 TUB2.036 5 µM -0.917388811974945 0.18186764300131 no 2790 0.179469466658621 3997 15992207 YFL037W TUB2 SGTC_408 cantharidin 100 µM -0.917734239006934 0.181777583587144 no 2791 0.179379008870256 3950 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_914 3820-6779 408 µM -0.918323279659309 0.181624073819771 no 2792 0.179224821544591 3940 2893481 SGTC_916 4466-0038 42 nM -0.918709646269152 0.18152342696495 no 2793 0.179123731474288 4066 5722064 YGL116W CDC20 SGTC_2076 5212012 200 µM -0.919620348311172 0.181286331116198 no 2794 0.178885594723421 3921 604802 SGTC_179 1273-0063 6.77 µM -0.920873181920177 0.180960480412602 no 2795 0.178558320784331 3972 3108139 SGTC_2795 7780010 54.55 µM -0.923576572182337 0.180258604444562 no 2796 0.177853408076607 4001 953673 SGTC_2089 5281248 129.67 µM -0.924021726048069 0.18014319404921 no 2797 0.177737502134333 3987 2737878 SGTC_453 enantio-paf c16 10 µM -0.92419364805219 0.180098634044961 no 2798 0.17769275108615 3864 13871343 A lipid and platelet activating factor SGTC_1928 4'-methoxychalcone 40.3 µM -0.924461945495946 0.180029108575157 no 2799 0.177622927856442 4044 641818 SGTC_2398 5228213 48.84 µM -0.924861712786033 0.179925545829704 no 2800 0.177518922300553 4012 80771 YMR134W ERG29 SGTC_3222 9128301 49.47 µM -0.926160289071391 0.179589398029467 no 2801 0.177181343175139 4018 4911358 SGTC_2839 9003951 25.97 µM -0.926946765914009 0.179386003668531 no 2802 0.17697708719293 4057 2990634 SGTC_2257 7960413 200 µM -0.927875826832426 0.179145921665352 no 2803 0.176735992465463 3992 2974689 YIL048W NEO1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.928747696830521 0.178920802506363 no 2804 0.176509927949617 4041 6708561 SGTC_2051 5263410 176 µM -0.928819396520882 0.178902297380864 no 2805 0.176491345297612 4028 227584 SGTC_2732 terfenadine 20 µM -0.929037817067255 0.178845932181967 no 2806 0.176434744130548 4017 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1196 1588-0294 184 µM -0.929752426226137 0.178661599595927 no 2807 0.176249641657494 4013 6144269 SGTC_1469 k284-2957 126 µM -0.931048647167024 0.178327546368975 no 2808 0.175914200276603 3971 23884841 SGTC_2948 9070189 9.45 µM -0.933586512604336 0.177674645478662 no 2809 0.175258612616432 3956 6473636 YDL196W YDL196W SGTC_1565 sinapyl alcohol 95.1 µM -0.934204854142373 0.177515797390262 no 2810 0.175099116137488 4060 5280507 A phenol propionate derived from cinnamic acid. SGTC_3172 9105863 49.47 µM -0.93549918755262 0.177183581505516 no 2811 0.174765550917626 4030 2348785 SGTC_1184 1269-1718 139 µM -0.936537566299329 0.176917345455884 no 2812 0.174498240087611 4077 5403821 SGTC_761 k216-0224 480 µM -0.937507794238834 0.176668811590942 no 2813 0.174248708192431 4017 1340404 SGTC_1065 prochlorperazine maleate 2.48 µM -0.938861112356797 0.176322514151586 no 2814 0.173901028669476 4067 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1059 3448-6867 171 µM -0.941419196172562 0.17566910616021 no 2815 0.173245040058135 3934 3934407 SGTC_276 colchicine 750 µM -0.941690288254099 0.175599951485926 no 2816 0.173175614342054 4104 2833 A microtubule depolymerizer. SGTC_3285 9112818 20.8695 µM -0.944883817603874 0.174786591941869 no 2817 0.17235909700033 4004 17017947 YPR165W RHO1 SGTC_369 0957-0393 4.5 µM -0.944909347751601 0.174780099322284 no 2818 0.172352579397081 4071 6997992 SGTC_480 am 92016 50 µM -0.944910108556431 0.174779905842934 no 2819 0.172352385173276 3995 2129 K+ channel blocker. SGTC_2297 7971671 152.32 µM -0.94563647680068 0.174595246049271 no 2820 0.172167016295224 4047 909016 SGTC_1191 1487-1166 10.6 µM -0.946099221506359 0.174477670151265 no 2821 0.172048990408171 4057 3955771 SGTC_2403 6032726 181.2 µM -0.9474544249203 0.174133624412671 no 2822 0.171703634630458 4093 2881040 SGTC_3055 9094636 49.47 µM -0.948944113968529 0.173755934658573 no 2823 0.171324518255884 4055 25236176 SGTC_1958 st076513 41.9 µM -0.950154950629493 0.173449328223654 no 2824 0.171016762595212 4000 732122 YGL099W LSG1 SGTC_1380 2291-0730 164 µM -0.950246502731784 0.173426159534894 no 2825 0.170993507389922 4074 2999191 SGTC_1818 st052136 56.3 µM -0.950844317222925 0.173274921677218 no 2826 0.170841705901892 3810 674169 SGTC_336 4111-0029 111 µM -0.951269908216221 0.17316730490061 no 2827 0.170733689247163 4038 3131175 SGTC_1097 itavastatin 7.23 µM -0.951437559800589 0.173124923486462 no 2828 0.17069115062473 4032 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2425 5628681 7.85 µM -0.95162256035495 0.173078164014633 no 2829 0.170644217882489 4096 5714958 SGTC_3121 9125696 49.47 µM -0.954312523550444 0.172399176435465 no 2830 0.169962735321519 4106 1235365 SGTC_2584 androsterone 48.74 µM -0.960236357024738 0.170909911016774 no 2831 0.168468136306977 4005 2754130 A steroid. SGTC_3006 9075424 71.4286 µM -0.96031640521087 0.170889843248498 no 2832 0.16844799797862 3984 7465181 SGTC_359 0081-0058 15.9 µM -0.960743492311076 0.1707827996592 no 2833 0.16834057860545 4135 3494159 SGTC_821 1114-0266 29.2 µM -0.962076328717443 0.170449018280232 no 2834 0.168005631863505 4070 3123235 SGTC_2170 morpholine 200 µM -0.963302125041661 0.170142411935936 no 2835 0.167697963592362 4075 121171 Reacts with secondary amines. SGTC_96 0929-0093 37.281 µM -0.96338764856498 0.170121033280493 no 2836 0.167676511198396 4037 6991579 SGTC_2976 9009005 19.48 µM -0.965148287561658 0.169681301889674 no 2837 0.167235271973237 4065 2993148 SGTC_1164 k060-0068 93.7 µM -0.967261031258201 0.169154593223922 no 2838 0.166706779562928 4057 5963676 SGTC_1984 st072354 53.1 µM -0.967848699848235 0.169008273798173 no 2839 0.16655996894782 3936 5762938 SGTC_3208 9114115 49.47 µM -0.968021158329438 0.168965350019861 no 2840 0.16651690143405 4075 650895 SGTC_1307 1187-1599 12.2 µM -0.969068936360431 0.168704715509783 no 2841 0.166255397651151 4030 1538471 SGTC_1141 3253-0389 52.6 µM -0.97029816762245 0.168399274118254 no 2842 0.165948945193304 4045 5402031 SGTC_3301 9125354 19.7965 µM -0.971204813580455 0.168174217278956 no 2843 0.16572314866726 4027 41905162 SGTC_3282 9108498 15.4605 µM -0.97513526486209 0.167200799955471 no 2844 0.164746583973959 4052 16459645 SGTC_658 3253-0951 102 µM -0.976436825405513 0.166879257014623 no 2845 0.164424019994648 4064 1184878 SGTC_2624 nerol 100 µM -0.978074790292489 0.166475174574466 no 2846 0.164018667586453 3966 637566 A natural product oil. SGTC_1435 4092-0789 56.7 µM -0.980025374470373 0.165994794346299 no 2847 0.163536796745453 4057 2248285 SGTC_2093 5331342 194.4 µM -0.981239011408352 0.165696358346318 no 2848 0.163237445212051 4145 33839 SGTC_452 diindolylmethane 8 µM -0.981746567938487 0.165571652023029 no 2849 0.163112358710241 4071 3071 Inhibits expression of several cancer promoting factors. SGTC_2742 clothiapine 36.27 µM -0.982918564704719 0.165283925123935 no 2850 0.162823760039538 4038 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_849 0386-0493 241 µM -0.984899001008082 0.16479846094949 no 2851 0.162336842069409 4036 726119 SGTC_511 blebbistatin 171 µM -0.986734011010995 0.164349470338285 no 2852 0.161886526058515 4140 3476986 A myosin inhibitor. SGTC_201 4262-0159 12.803 µM -0.987892451311981 0.16406643169786 no 2853 0.161602661400464 4108 1341029 SGTC_2421 5690543 90.72 µM -0.988912978532859 0.163817351129872 no 2854 0.161352860011416 4092 3397993 SGTC_886 0866-0150 153 µM -0.989082233624651 0.1637760646982 no 2855 0.161311454651868 4144 271463 SGTC_2306 7482397 179.52 µM -0.992674078871209 0.162901497773416 no 2856 0.160434405494567 4092 891448 SGTC_1615 st002656 86.5 µM -0.993175144033441 0.162779736811077 no 2857 0.160312304566545 4075 1584458 SGTC_2222 6885208 172.143 µM -0.994179046558982 0.16253596237455 no 2858 0.160067853637192 4025 609514 SGTC_65 0798-0905 34.986 µM -0.996381453892004 0.162001991505737 no 2859 0.159532420318779 4202 3602145 SGTC_109 0132-0036 33.701 µM -0.998511805566921 0.161486578866996 no 2860 0.15901562136558 3886 67274 A color developer. SGTC_2575 plumbagin 510 nM -1.00027221183542 0.161061477718645 no 2861 0.158589395601346 3997 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1900 st060200 72.8 µM -1.00053609231039 0.16099781911889 no 2862 0.158525570057285 4078 688945 SGTC_279 1273-0055 2.93 µM -1.00056358230843 0.16099118836865 no 2863 0.158518921939935 4104 2847562 SGTC_1073 triclabendazole 3.09 µM -1.00069390745176 0.160959755598206 no 2864 0.158487406897966 4152 50248 An antihelmetic and likely tubulin inhibitor. SGTC_713 1488-1073 324 µM -1.00607021754036 0.159666549327554 no 2865 0.157190896980978 4025 3312542 SGTC_2339 9000433 200 µM -1.0066170909105 0.159535387588669 no 2866 0.157059409063048 4122 2988954 SGTC_1160 4092-0570 10.5 µM -1.00784288822656 0.159241649466261 no 2867 0.156764946426785 4082 4994975 SGTC_2014 4013930 200 µM -1.01147886579821 0.15837244411567 no 2868 0.155893645667155 4034 64556 SGTC_2914 7968218 45.32 µM -1.01149699817981 0.158368117260139 no 2869 0.155889308562797 4056 2977111 SGTC_963 1269-2853 151 µM -1.0116278642298 0.1583368915334 no 2870 0.155858008926685 4103 3668223 SGTC_806 3966-4455 5.86 µM -1.01677595901815 0.157111718560876 no 2871 0.154630010631017 4096 714982 SGTC_1357 1503-1303 39.5 µM -1.01795874048837 0.15683111660379 no 2872 0.154348782152858 4061 292895 SGTC_1126 isoteolin 1.0172 µM -1.0213377788471 0.15603129462979 no 2873 0.153547216695168 4054 133323 SGTC_3190 9110366 49.47 µM -1.02289322834017 0.155664023224898 no 2874 0.153179165787053 4118 17123768 SGTC_625 k213-0058 121 µM -1.02324631897826 0.155580731232998 no 2875 0.153095698867926 4171 3655420 SGTC_1404 3909-7820 48.3 µM -1.02443583542119 0.155300347724404 no 2876 0.152814731552598 4090 23741373 SGTC_2194 5927483 104.545 µM -1.02566098522162 0.155011913841147 no 2877 0.152525705234576 4140 760979 SGTC_2366 9070441 60.58 µM -1.02711482137655 0.154670100167224 no 2878 0.152183200194385 4102 6837235 SGTC_1185 1319-0113 81.3 µM -1.02779197382186 0.154511063949945 no 2879 0.152023846272709 4184 4672763 SGTC_50 0929-0078 56.389 µM -1.02806272270159 0.154447506050522 no 2880 0.151960162110639 3981 1377751 SGTC_3267 9137951 49.47 µM -1.03117629180755 0.153717842666752 no 2881 0.151229078160615 4158 16643986 SGTC_3084 9116877 49.47 µM -1.03160908371988 0.153616599046304 no 2882 0.151127641652229 4062 27241325 SGTC_3144 9087057 49.47 µM -1.03268896277304 0.153364173992449 no 2883 0.150874740175481 3997 17249618 SGTC_2800 7887935 81.82 µM -1.03614380561009 0.15255844063783 no 2884 0.150067529156117 4133 2961002 SGTC_3342 9147791 14.508 µM -1.0365864206393 0.152455417949141 no 2885 0.149964322275112 4034 1838168 SGTC_287 k060-0039 29.6 µM -1.03676759645618 0.152413260944209 no 2886 0.149922090209521 4180 5861974 SGTC_549 1661-1316 519 µM -1.03695099953206 0.152370593568965 no 2887 0.149879347048943 4159 2857282 SGTC_773 4358-1457 44.6 µM -1.03773981649095 0.152187171498061 no 2888 0.149695601296169 4138 1186886 SGTC_796 1234-0020 70.7 µM -1.04166660532435 0.151276265169632 no 2889 0.14878313840669 4066 46495034 SGTC_3240 9133527 49.47 µM -1.04239297704567 0.151108165313405 no 2890 0.148614760596872 4079 17617455 SGTC_1789 tunicamycin 25 nM -1.04388608810203 0.150763014021527 no 2891 0.14826904771401 4037 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1129 3453-1384 223 µM -1.04396268425507 0.150745322028447 no 2892 0.148251327265448 4232 1084452 SGTC_1540 guanosine 70.6 µM -1.0447403414569 0.150565778923529 no 2893 0.148071497215065 4008 6802 Guanosine is a purine nucleoside SGTC_2011 4012611 177 µM -1.04537056235811 0.150420379985703 no 2894 0.147925868342848 4142 2049887 SGTC_3064 1327-0027 10 µM -1.04694957359771 0.150056495545368 no 2895 0.147561418052282 4050 16000455 YPR107C YTH1 SGTC_1558 st069300 45.6 µM -1.05023061285778 0.149302255532389 no 2896 0.146806049016904 4077 24208000 SGTC_2419 paclitaxel 166.5 µM -1.05431554879159 0.148366760328742 no 2897 0.145869236150167 4073 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_752 1896-0090 130 µM -1.05440086451767 0.148347263978895 no 2898 0.145849713318169 4131 772567 SGTC_2830 7992007 71.43 µM -1.05459386619844 0.14830316555798 no 2899 0.145805555145658 4023 1952075 SGTC_2151 5563267 85.4165 µM -1.05492450358168 0.148227639516794 no 2900 0.145729927246302 4188 5310824 SGTC_2359 9039622 200 µM -1.05660273165399 0.147844686114205 no 2901 0.145346466649584 4096 6463596 SGTC_3102 9121669 49.47 µM -1.05884809264261 0.147333356038557 no 2902 0.144834483582722 4187 41905072 SGTC_1910 st062352 60.4 µM -1.06059403814853 0.146936576561867 no 2903 0.144437216566598 4059 2245730 SGTC_1265 0819-1001 68.8 µM -1.0612772904539 0.146781497532957 no 2904 0.14428195155235 4115 3106768 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.06231694493481 0.146545735980118 no 2905 0.144045912180732 4102 5711223 A potent inhibitor of glutathione S-transferases. SGTC_170 4197-0004 226 µM -1.06577272993055 0.145763897943613 no 2906 0.143263195540481 4183 218692 SGTC_2251 lansoprazole 556 µM -1.06632681161372 0.145638803601401 no 2907 0.143137966732226 4085 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3313 9133968 57.047 µM -1.06711295149101 0.145461441654479 no 2908 0.142960417034836 4150 1494643 SGTC_189 3970-0742 2.116 µM -1.06762947589425 0.145344987087039 no 2909 0.142843841043186 4088 2891807 SGTC_1597 7-benzyloxygramine 47.5 µM -1.06797895740387 0.14526622926248 no 2910 0.142765001932677 4093 260807 SGTC_539 4859-0462 2.54 µM -1.07220766190149 0.144315540225221 no 2911 0.141813384888807 4221 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2187 6125751 200 µM -1.07316399719029 0.144101121567501 no 2912 0.141598770559498 4176 874498 SGTC_321 4534-3890 65.3 µM -1.07390011438175 0.143936224099137 no 2913 0.141433726037728 4161 699746 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.07564044976465 0.143546878239175 no 2914 0.141044044814251 4142 6708739 YPR165W RHO1 SGTC_2754 granisetron 64.02 µM -1.07617004577653 0.143428538832443 no 2915 0.140925606781705 4180 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3161 9100388 49.47 µM -1.07995132737767 0.142585517359444 no 2916 0.140081927503261 4241 25236368 SGTC_299 1273-0059 1.44 µM -1.08037565433152 0.142491124909105 no 2917 0.139987466304013 4018 2848077 SGTC_150 3970-0969 77.2 µM -1.0807581325616 0.142406078023092 no 2918 0.139902358324368 4259 6615640 SGTC_1147 3809-1045 12.3 µM -1.08148548212863 0.142244441179277 no 2919 0.139740607587932 4162 325925 SGTC_923 1900-2434 73.3 µM -1.08206110841586 0.142116609405796 no 2920 0.139612687803773 4132 5910570 SGTC_1222 0366-0074 1.18 µM -1.08309843872638 0.141886441425276 no 2921 0.139382365954818 4193 286520 SGTC_1620 st003704 16.5 µM -1.08506227447618 0.141451387426971 no 2922 0.138947037314801 4165 2834414 SGTC_2442 5158906 48.48 µM -1.08507482680653 0.141448609584956 no 2923 0.138944257787381 4203 1893835 SGTC_1257 0669-0121 16 µM -1.08900535300493 0.140580598452025 no 2924 0.138075762557049 4194 4307855 SGTC_2002 4023503 131 µM -1.09015931824111 0.140326446639671 no 2925 0.137821485114063 4193 4736863 YCR052W RSC6 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.09115022576415 0.140108456168447 no 2926 0.137603392725912 4242 6710655 SGTC_2386 9075165 157.42 µM -1.09195095850162 0.139932470542811 no 2927 0.137427328763006 4161 16452277 SGTC_554 4483-2211 187 µM -1.09214956973714 0.139888842882475 no 2928 0.13738368222786 4243 747107 SGTC_952 1185-0122 232 µM -1.09437291052633 0.139401086823793 no 2929 0.13689572993472 4133 678600 SGTC_2935 9038016 29.96 µM -1.09463203363396 0.139344315815829 no 2930 0.136838937853296 4167 6463195 SGTC_1002 4049-0206 172 µM -1.09703719344735 0.138818122492713 no 2931 0.136312566796138 4154 4662749 SGTC_2744 captopril 92.04 µM -1.10227322470064 0.137677284475319 no 2932 0.135171453075593 4242 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2808 7946468 45.46 µM -1.10254744788473 0.137617712965573 no 2933 0.135111871314339 4188 2970879 SGTC_558 k064-0027 21.3 µM -1.10272059820131 0.137580107317534 no 2934 0.135074259407487 4201 5088526 SGTC_1242 0402-0103 60.1 µM -1.10373545233981 0.137359837285377 no 2935 0.134853956023725 4117 432868 SGTC_1752 st044819 83.042 µM -1.10423593379125 0.13725129850061 no 2936 0.134745402885985 4174 441209 YML126C ERG13 SGTC_42 0133-0086 60.653 µM -1.10456912609592 0.137179071992114 no 2937 0.134673167588697 4082 162923 Model of phenazepam hydroxylation. SGTC_1519 esterone 74 µM -1.10789083523532 0.136460440612395 no 2938 0.133954482041184 4166 698 A steroid. SGTC_3014 9081533 49.47 µM -1.10960501009186 0.136090598489782 no 2939 0.13358463569919 4245 21367265 SGTC_1714 st033236 13.627 µM -1.11034228591296 0.135931738606222 no 2940 0.133425778958672 4243 2916566 SGTC_1007 4101-0031 70 µM -1.11081926744719 0.135829031668791 no 2941 0.133323075641497 4179 1146276 SGTC_465 cgp-37157 41 µM -1.11500356704567 0.134930317525413 no 2942 0.132424446578669 4168 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_860 0443-0016 25.1 µM -1.11533812065298 0.134858637792155 no 2943 0.132352777772669 4233 5337942 SGTC_2829 7992743 58.44 µM -1.11887939900949 0.134101503415852 no 2944 0.131595796386416 4214 16462845 SGTC_597 k018-0003 82.8 µM -1.1202020915192 0.133819458877215 no 2945 0.131313826448184 4284 6786234 SGTC_3127 9126946 49.47 µM -1.12268232873338 0.133291684883817 no 2946 0.130786217857665 4202 27243249 SGTC_2395 5646831 180.19 µM -1.12987000741219 0.131770302380551 no 2947 0.129265501811625 4244 6808628 SGTC_649 1123-0311 367 µM -1.13045637952158 0.131646718438514 no 2948 0.129141984461154 4115 693629 YIL048W NEO1 SGTC_3291 9121177 71.43 µM -1.13075961038421 0.131582840808421 no 2949 0.129078141988338 4220 17015612 SGTC_2502 avocadyne acetate 18.59 µM -1.13324969289749 0.131059097214508 no 2950 0.128554705657612 4165 3952079 SGTC_57 miconazole 162.5 nM -1.13384770837594 0.130933530296459 no 2951 0.128429217451369 4091 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2645 abamectin 100 µM -1.13408058864061 0.130884654298655 no 2952 0.128380372620412 4182 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1120 ficusin 1.78878 µM -1.13416864012936 0.130866177682379 no 2953 0.128361907863393 4271 6199 A DNA cross-linker. SGTC_2195 6536160 144.242 µM -1.13752852509497 0.130162489988387 no 2954 0.127658703453234 4200 3834386 SGTC_2199 6590217 200 µM -1.13838283865847 0.129983982540992 no 2955 0.127480328430083 4123 703109 SGTC_1338 1486-1223 76 µM -1.13896084516995 0.129863305163098 no 2956 0.12735974283622 4241 3444526 SGTC_312 4092-0653 6.84 µM -1.14179018761685 0.129273708595967 no 2957 0.126770620996693 4147 1148278 SGTC_939 1165-0479 45.3 µM -1.14220388399982 0.129187655607273 no 2958 0.126684640955999 4225 1377347 SGTC_1567 st069303 68.4 µM -1.14480109467204 0.128648317022792 no 2959 0.126145780894283 4278 5581319 SGTC_905 2-aminofluorene 215 µM -1.1456581389161 0.128470685963989 no 2960 0.125968315508064 4254 1539 An established DNA mutagen. YPR165W RHO1 SGTC_830 4076-0286 57.8 µM -1.14671904821129 0.128251037720618 no 2961 0.125748877673069 4313 6866659 SGTC_389 tpck 16.7 µM -1.14864101189598 0.127853783179991 no 2962 0.125352019295799 4258 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3271 9137798 49.47 µM -1.14987199995267 0.127599797452607 no 2963 0.125098297429402 4188 6498326 SGTC_2676 harmalol 100 µM -1.15049097960663 0.127472218036132 no 2964 0.12497085367247 4197 5459187 A monoamine oxidase inhibitor SGTC_23 0213-0011 39.996 µM -1.15106591980323 0.127353795186719 no 2965 0.124852558616172 4255 627608 SGTC_1474 0330-0125 5.35 µM -1.15339841882419 0.126874145603423 no 2966 0.124373445093785 4271 X1474 SGTC_2553 4-methylesculetin 85.09 µM -1.15408121879226 0.126733974492964 no 2967 0.124233436244103 4271 5319502 SGTC_2394 5221648 200 µM -1.15555347055016 0.126432104886058 no 2968 0.123931924712464 4289 788586 SGTC_709 3807-1509 243 µM -1.15744661272122 0.126044672917269 no 2969 0.123544969639404 4320 1886677 YPL242C IQG1 SGTC_2066 5222451 176 µM -1.15787755657358 0.125956595940307 no 2970 0.123457003802072 4204 2281147 SGTC_178 4092-0806 87.505 µM -1.15856295927956 0.125816600692633 no 2971 0.123317187288171 4145 2169044 SGTC_1116 jasmonic acid  1.58368 µM -1.15862336798635 0.125804267266688 no 2972 0.123304869731034 4303 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_993 3909-8757 62.7 µM -1.15938877705911 0.125648069512041 no 2973 0.123148874667359 4194 4288324 YLR208W SEC13 SGTC_3239 9133757 49.47 µM -1.16082891858971 0.125354545381775 no 2974 0.122855740064143 4289 17036923 SGTC_2338 7999974 200 µM -1.16196330082655 0.125123677202734 no 2975 0.122625186199624 4254 315925 SGTC_327 1273-0057 3.96 µM -1.16660489507544 0.124182119204555 no 2976 0.121684982804233 4143 3108138 SGTC_1013 4112-3890 241 µM -1.16670879067392 0.124161100612422 no 2977 0.12166399578937 4197 705171 SGTC_2772 vinpocetine 57.06 µM -1.16838139486768 0.123823067047924 no 2978 0.121326478132508 4277 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1547 harmine 94.2 µM -1.16861258179012 0.123776394860307 no 2979 0.121279878370542 4205 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1742 st038235 28.8875 µM -1.16868782235658 0.123761207895527 no 2980 0.121264715035393 4301 564103 YBR002C RER2 SGTC_3304 9125678 46.087 µM -1.16876783050259 0.123745060047792 no 2981 0.121248592346058 4185 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1192 1488-0095 21.4 µM -1.17000247209714 0.123496062361598 no 2982 0.120999987002314 4304 915875 SGTC_1306 1185-0270 9.02 µM -1.17453648966542 0.122584671016447 no 2983 0.120090102541534 4294 1548076 SGTC_1648 st011736 69.8 µM -1.17464117327085 0.12256368424994 no 2984 0.120069151789864 4262 2855514 SGTC_890 0929-0006 47.2 µM -1.17653051424405 0.122185346088373 no 2985 0.119691473087129 4240 1378169 SGTC_1382 3002-2117 298 µM -1.17690061182288 0.122111330655682 no 2986 0.119617588931044 4330 1497314 SGTC_3010 9080089 71.4286 µM -1.177731814758 0.121945214008581 no 2987 0.119451769618675 4284 17027233 SGTC_1121 fusaric acid 630.51 nM -1.17912016036483 0.121668105995128 no 2988 0.119175165945112 4225 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2280 7785178 200 µM -1.17966273054185 0.121559931594401 no 2989 0.119067191258503 4254 2954328 SGTC_3032 9089427 49.47 µM -1.18114277077904 0.121265193783246 no 2990 0.118773005697094 4264 17173707 SGTC_2706 st078239 82.5 µM -1.18135151917251 0.121223663736174 no 2991 0.118731554418553 4243 15434492 SGTC_318 1488-0629 67.2 µM -1.18220462685952 0.121054043761076 no 2992 0.118562258605747 4322 3662576 SGTC_1924 st058459 75.1 µM -1.18447108966863 0.120604223328311 no 2993 0.11811331693486 4217 688683 SGTC_2452 5863136 48.41 µM -1.18654007883509 0.1201946237736 no 2994 0.117704541790501 4225 2184096 SGTC_1884 5633444 25 µM -1.18895440234598 0.119717898504674 no 2995 0.117228805247497 4249 5724239 SGTC_3008 9078912 71.4286 µM -1.19024975815298 0.119462671672279 no 2996 0.11697412072005 4274 16648731 SGTC_1431 4049-0260 9.09 µM -1.19542850295271 0.118446128212121 no 2997 0.115959827480845 4281 3854841 SGTC_1405 3909-7894 12 µM -1.19628150086194 0.118279280202955 no 2998 0.115793362662901 4263 7104060 SGTC_853 0419-0306 21 µM -1.19661291658369 0.118214499503889 no 2999 0.115728731799948 4299 762713 SGTC_1206 3978-0017 132 µM -1.19798319339271 0.11794692249501 no 3000 0.115461779969113 4357 3873677 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.19802076595888 0.117939591656447 no 3001 0.115454466401092 4286 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1880 MG-132 525 µM -1.19919578697242 0.117710494233835 no 3002 0.1152259125392 4229 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1251 0490-5699 265 µM -1.19920057480274 0.11770956138074 no 3003 0.115224981914618 4325 3883818 SGTC_1675 st018485 24.5 µM -1.19943768291978 0.11766337016523 no 3004 0.115178901200732 4313 3323024 SGTC_3244 9134489 49.47 µM -1.20118193343831 0.117323965691186 no 3005 0.114840317969394 4299 16584271 SGTC_2946 9065502 71.43 µM -1.20216615921375 0.117132756704851 no 3006 0.114649578865664 4114 16489101 SGTC_2974 9094440 9.66 µM -1.2031863951629 0.116934785048207 no 3007 0.114452099209055 4284 25236134 SGTC_3038 9091290 49.47 µM -1.20577630596444 0.11643329129787 no 3008 0.113951876886158 4304 25236843 SGTC_2537 larixol 68.93 µM -1.20858655277879 0.115890861068452 no 3009 0.113410862587623 4269 6708759 SGTC_2471 5466956 24.79 µM -1.20936621336217 0.115740690448749 no 3010 0.113261091475945 4277 724419 SGTC_944 3370-0224 231 µM -1.21012106557706 0.115595429904079 no 3011 0.113116220484908 4293 4580514 SGTC_1771 st048882 4.1505 µM -1.21034580455032 0.115552207124602 no 3012 0.113073114209225 4333 4580403 SGTC_1913 st060213 96.1 µM -1.21144702760152 0.115340581085036 no 3013 0.112862062508421 4311 688959 SGTC_2185 6113692 200 µM -1.21190801695897 0.115252072927611 no 3014 0.112773796487556 4297 874150 SGTC_3185 9108267 49.47 µM -1.21462195679188 0.114731985814365 no 3015 0.11225515528556 4299 4910486 SGTC_678 1218-2179 85.9 µM -1.21711563702507 0.114255582313684 no 3016 0.111780111001796 4313 6820081 YOR116C RPO31 SGTC_852 0418-0143 439 µM -1.21801377323963 0.114084344001752 no 3017 0.11160936939867 4293 5369229 SGTC_493 zm226600 134 µM -1.21986114367941 0.113732699971637 no 3018 0.111258758942705 4323 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.22009327346873 0.113688569131533 no 3019 0.111214759105892 4321 94937 An inhibitor of serotonin biosynthesis. SGTC_581 0958-0271 211 µM -1.22015157481743 0.113677487218047 no 3020 0.111203710134588 4304 4591145 SGTC_3049 9092223 49.47 µM -1.22082277051926 0.11354996187781 no 3021 0.11107656518664 4282 8623917 SGTC_2193 5925765 200 µM -1.22094978163415 0.113525841596681 no 3022 0.111052517124452 4306 877370 SGTC_163 TUB2.036 7.546 µM -1.22210324654067 0.11330695794126 no 3023 0.110834292780256 4271 15992207 YJR013W GPI14 SGTC_861 0443-0273 110 µM -1.22249635668109 0.113232429451548 no 3024 0.110759990406788 4304 6149169 SGTC_771 0250-0039 27.3 µM -1.22403561720215 0.112940942574625 no 3025 0.110469395833341 4270 3005115 SGTC_2653 dihydrofissinolide 100 µM -1.22524344838431 0.112712593166976 no 3026 0.110241754310501 4353 6857746 SGTC_292 k038-0015 474 µM -1.23120554779333 0.111590244263152 no 3027 0.109122998504825 4301 46368540 SGTC_800 3448-7362 155 µM -1.2315428085551 0.111526995663126 no 3028 0.109059958048081 4387 15991913 SGTC_1264 0783-0040 158 µM -1.23426421402412 0.111017572126911 no 3029 0.108552233112476 4218 2855798 SGTC_2644 guaiazulene 100 µM -1.23439271420238 0.110993559278478 no 3030 0.108528301306215 4327 3515 A coloring agent. SGTC_1087 pterostilbene 9.05 µM -1.238591118936 0.110211048128548 no 3031 0.107748479350152 4323 5281727 Similar to reservatol, lowers cholesterol. SGTC_1156 4092-0367 4.88 µM -1.23920596350054 0.110096784563327 no 3032 0.107634616327214 4340 1357585 SGTC_7 0192-1582 4.227 µM -1.23959805387241 0.110023962338613 no 3033 0.107562050424321 4361 252616 SGTC_6 0844-0013 19.835 µM -1.2406500050287 0.109828756139916 no 3034 0.107367535352483 4460 1584900 SGTC_706 4262-0057 46.9 µM -1.24089513246377 0.10978330459435 no 3035 0.107322245572351 4316 883298 SGTC_3189 9110682 49.47 µM -1.24093641773737 0.109775650804791 no 3036 0.107314619054604 4358 17122418 SGTC_2434 5670830 169.91 µM -1.24229499857823 0.10952400002526 no 3037 0.107063869999234 4343 1549830 SGTC_1440 4100-1550 40 µM -1.24284554522253 0.10942213996947 no 3038 0.106962377721238 4308 742806 SGTC_2867 9039098 71.43 µM -1.24561761312555 0.108910296219439 no 3039 0.10645240645316 4304 6463460 SGTC_1856 st057054 55.7 µM -1.24853532867935 0.108373421264652 no 3040 0.105917539491556 4331 1266018 SGTC_2261 9010538 184.68 µM -1.25138330783185 0.10785121739009 no 3041 0.105397332152702 4338 6457250 SGTC_5 0352-0601 109.883 µM -1.2525831932361 0.107631750550788 no 3042 0.105178717237105 4227 762456 SGTC_2267 7931562 200 µM -1.25696925553402 0.106832249479612 no 3043 0.104382384290269 4268 934880 SGTC_607 4491-0986 66.8 µM -1.25886184556834 0.10648859065705 no 3044 0.10404011858685 4343 698981 YDR232W HEM1 SGTC_2370 9071495 200 µM -1.26719312777588 0.104985275532713 no 3045 0.102543121225166 4347 21791103 SGTC_1583 clindamycin 39.6 µM -1.27030365132197 0.104427962853858 no 3046 0.10198824403604 4308 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2480 5767542 37.17 µM -1.2709431609828 0.104313648034412 no 3047 0.101874435072435 4265 2867358 SGTC_2931 9014674 55.67 µM -1.27232182522094 0.104067515045247 no 3048 0.10162939854698 4305 2996810 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.27282821622988 0.10397721485587 no 3049 0.101539503126723 4370 6728940 SGTC_1512 0259-0544 12.2 µM -1.27432020820028 0.103711491597738 no 3050 0.101274978782303 4310 18476 SGTC_983 1491-0821 12.2 µM -1.27435274818247 0.103705701732898 no 3051 0.101269215170707 4334 46495113 SGTC_1227 3909-8010 46.6 µM -1.27700127626599 0.103235233050008 no 3052 0.100800898340314 4338 15982272 SGTC_2302 7771753 200 µM -1.27746545475777 0.103152939017348 no 3053 0.100718984489409 4340 2203047 SGTC_1518 st038567 90.8 µM -1.28101998135597 0.102524337116121 no 3054 0.100093323918961 4296 77966 SGTC_1182 1222-0449 220 µM -1.28202994862758 0.102346238103611 no 3055 0.0999160703002429 4348 658318 SGTC_2909 7941780 10.49 µM -1.28478042820259 0.101862355712609 no 3056 0.0994345117621329 4324 1243215 SGTC_820 1582-0060 59.9 µM -1.28788563240546 0.101318071441074 no 3057 0.0988928887794923 4385 3848840 SGTC_1605 st000082 49.1 µM -1.28820586751753 0.101262060963494 no 3058 0.0988371550235956 4320 1114022 SGTC_1455 4262-0120 131 µM -1.29350578175169 0.100338357824037 no 3059 0.0979180928406195 4425 1529587 SGTC_798 1287-0182 476 µM -1.30439038967614 0.0984606309684758 no 3060 0.0960502551083208 4409 1649755 SGTC_2818 7996756 12.99 µM -1.3047520896425 0.098398678064519 no 3061 0.0959886389924937 4386 2241621 SGTC_3266 9136860 49.47 µM -1.30491174631384 0.0983713407405528 no 3062 0.0959614504947709 4154 4871271 YPR165W RHO1 SGTC_648 0375-0473 33.3 µM -1.31198618222985 0.0971655927172221 no 3063 0.0947623984082594 4348 1713139 SGTC_2820 7989630 71.43 µM -1.31719960152499 0.0962839977443287 no 3064 0.0938858637284088 4401 2984098 SGTC_2202 7226349 200 µM -1.32455332065681 0.0950504908288533 no 3065 0.0926596734579142 4366 844334 SGTC_595 3909-8003 73.7 µM -1.32983299303703 0.0941720882592649 no 3066 0.0917866513854725 4449 699517 SGTC_477 mead ethanolamide 10 µM -1.33944464558121 0.092588354451833 no 3067 0.0902129817268039 4353 16061185 SGTC_3017 9080681 49.47 µM -1.3400239707701 0.0924935311203616 no 3068 0.0901187759571751 4408 16451914 SGTC_100 0086-0128 49.5915 µM -1.34036898657547 0.0924370934469111 no 3069 0.0900627066586887 4397 93297 SGTC_478 N-arachidonylglycine 10 µM -1.34187915432805 0.0921903601022135 no 3070 0.0898175908776531 4390 5283389 SGTC_159 3970-0959 50 µM -1.34196442196782 0.0921764435087251 no 3071 0.0898037658653512 4442 6615653 SGTC_1525 8-methoxypsoralen 92.5 µM -1.34203227982848 0.092165369489257 no 3072 0.0897927647472519 4435 4114 Related to psoralen; DNA damaging agent. SGTC_2405 ticlatone 3.52 µM -1.34360371779242 0.0919091951153004 no 3073 0.0895382833239951 4203 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2309 7664088 163.95 µM -1.34530339758533 0.0916327089417827 no 3074 0.0892636384118344 4390 704922 SGTC_466 geldanamycin 89.2 µM -1.35157682484749 0.0906175479885687 no 3075 0.0882553641074753 4412 5288382 HSP90 inhibitor. SGTC_1862 st057513 3.81 µM -1.35213230976147 0.0905280637839777 no 3076 0.0881664965144623 4389 5393163 SGTC_1865 st057639 52.2 µM -1.35616406684819 0.0898805449360292 no 3077 0.0875234860907887 4394 688818 SGTC_526 4469-0568 170 µM -1.35628594777294 0.0898610240382324 no 3078 0.0875041023836779 4362 2901964 SGTC_2520 obtusaquinone 4.71 µM -1.35993988551093 0.089277258302343 no 3079 0.086924473938335 4447 5967872 SGTC_1319 1306-0155 43.7 µM -1.36054590691647 0.0891807116323 no 3080 0.0868286180002363 4453 3122360 SGTC_1949 st076024 69.1 µM -1.36323792492342 0.0887527789938794 no 3081 0.0864037692136388 4367 2921930 SGTC_1044 1222-0021 1.78 µM -1.36355558762765 0.0887023832541678 no 3082 0.0863537390420988 4334 4306703 SGTC_1416 3966-0321 25.3 µM -1.36483007548542 0.0885004058322779 no 3083 0.0861532318371614 4451 582530 YLR208W SEC13 SGTC_3226 9131256 49.47 µM -1.36529511372287 0.0884267932015806 no 3084 0.0860801570671091 4391 17178073 SGTC_1485 3909-9022 254 µM -1.3654158103469 0.0884076951435906 no 3085 0.0860611987287014 4472 714516 SGTC_34 0469-0683 81.75 µM -1.36680774133018 0.088187669297814 no 3086 0.0858427878391144 4380 3690923 SGTC_3229 9132204 49.47 µM -1.36891498705597 0.0878553490603317 no 3087 0.0855129252066071 4500 17682924 SGTC_1539 benzyladenosine 56 µM -1.37010071329769 0.0876687668794569 no 3088 0.0853277326055541 4422 92208 A nucleotide analog. SGTC_1670 st016595 4.04 µM -1.3721691245194 0.0873439960786414 no 3089 0.0850053973382874 4433 597879 SGTC_1425 4048-4433 7.33 µM -1.37330067060178 0.0871667072955504 no 3090 0.0848294471110002 4483 23734946 SGTC_439 amiodarone 34.4 µM -1.37380667264503 0.0870875147318921 no 3091 0.0847508545273685 4289 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_294 k038-0071 157 µM -1.37565788122146 0.0867982465960521 no 3092 0.0844637888109621 4424 24152826 SGTC_1388 3346-4487 254 µM -1.37672274311408 0.0866321778593004 no 3093 0.0842989922065739 4487 3345614 SGTC_2815 7968870 71.43 µM -1.37679828953441 0.0866204051730371 no 3094 0.0842873099166479 4358 2977326 YHR190W ERG9 SGTC_44 0929-0055 61.211 µM -1.37774789967352 0.0864725257789577 no 3095 0.0841405684317586 4301 1379590 SGTC_81 0411-0046 9.971 µM -1.37918024054175 0.0862498296356091 no 3096 0.0839195943752822 4405 12925265 SGTC_1345 1488-0192 31.4 µM -1.37994188438602 0.0861315863208649 no 3097 0.0838022695729895 4470 658348 SGTC_2109 5483026 200 µM -1.37999695437154 0.0861230415457944 no 3098 0.083793791285283 4425 759335 SGTC_3115 9123671 49.47 µM -1.38068404744264 0.0860164840455194 no 3099 0.0836880641803051 4567 3286988 SGTC_2143 5623677 140.463 µM -1.38269868568 0.0857046135318991 no 3100 0.0833786375430259 4368 5375313 SGTC_2943 9068529 45.32 µM -1.38296270582992 0.0856638054393997 no 3101 0.0833381507214261 4390 3270634 SGTC_623 k072-0108 16.9 µM -1.38544582781662 0.0852807149680397 no 3102 0.0829580930952544 4402 5382803 SGTC_1103 duloxetine 36.1 µM -1.38734655713712 0.084988343062779 no 3103 0.0826680564294668 4485 60835 A selective serotonin reuptake inhibitor. SGTC_3176 9106582 49.47 µM -1.38758327471256 0.0849519836271338 no 3104 0.0826319886551578 4420 17018027 SGTC_877 0771-0151 33.1 µM -1.38762120229259 0.0849461590963225 no 3105 0.0826262108722246 4441 6166523 SGTC_2431 5490079 200 µM -1.38934361346371 0.084681964142816 no 3106 0.0823641438411554 4463 5722345 SGTC_2203 7227154 166.4 µM -1.38988744925131 0.0845986751045535 no 3107 0.0822815286846881 4454 896304 SGTC_1650 st011916 45.8 µM -1.39026431826307 0.084540993262763 no 3108 0.0822243143960155 4371 242528 SGTC_1725 st036284 20.55 µM -1.39470497913069 0.083863546439151 no 3109 0.0815524114004209 4462 707914 SGTC_2372 9071633 200 µM -1.39534591643249 0.0837661056316552 no 3110 0.0814557760015492 4472 21321366 SGTC_1037 k284-1091 78.7 µM -1.39601957355418 0.0836637821681137 no 3111 0.0813543004820363 4398 3334711 SGTC_579 4491-1009 110 µM -1.40171099032794 0.0828030438025693 no 3112 0.08050078369591 4525 1271041 SGTC_266 formosanin C 406 nM -1.40583479202173 0.0821835578059817 no 3113 0.079886594051476 4293 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.40896925268274 0.0817150326440425 no 3114 0.0794221300562202 4445 115019 SGTC_410 α-linolenic acid 100 µM -1.40957689088165 0.081624439068395 no 3115 0.0793323272859832 4472 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3134 9127454 49.47 µM -1.41126693969738 0.0813728656980524 no 3116 0.0790829593931015 4492 24262820 SGTC_1923 st058458 19.1 µM -1.41254470319435 0.0811830519168325 no 3117 0.0788948188843344 4443 3534982 SGTC_1234 0326-0494 15.5 µM -1.41750423205504 0.0804494702153822 no 3118 0.0781677789549897 4505 1547813 SGTC_1780 st038448 24.544 µM -1.41917690087447 0.0802031924585695 no 3119 0.0779237242676122 4477 728868 YDL195W SEC31 SGTC_3321 9137793 26.8275 µM -1.42201488745584 0.079786641740746 no 3120 0.0775109645646095 4406 4904192 SGTC_2673 kobusone 100 µM -1.42463720155308 0.0794032032264601 no 3121 0.0771310502663485 4552 6710676 An epoxy ketone and protein crosslinker. SGTC_1520 flindersine 88 µM -1.42472568809326 0.0793902889663842 no 3122 0.0771182552811919 4470 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1034 k072-0165 12.7 µM -1.42697881930437 0.0790619887624884 no 3123 0.0767929999404242 4469 5835461 SGTC_2776 terbinafine 19.92 µM -1.42729186978675 0.0790164561376461 no 3124 0.0767478915491582 4461 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2892 9047358 58.44 µM -1.43307211208858 0.0781792952632671 no 3125 0.075918615126969 4462 6466771 SGTC_2129 girgensonine 121.053 µM -1.4331725532919 0.0781648079162593 no 3126 0.0759042656402665 4450 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2025 5147754 141 µM -1.43460046381229 0.0779590704489505 no 3127 0.0757004911837395 4421 315777 YLR208W SEC13 SGTC_468 gf-109203x 121 µM -1.43601779165311 0.0777552643644619 no 3128 0.075498639339287 4522 2396 A protein kinase C inhibitor. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.4361279859325 0.0777394358269449 no 3129 0.0754829629802993 4478 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2485 5633444 17.78 µM -1.4365236861357 0.0776826167801417 no 3130 0.0754266906817033 4435 5724239 SGTC_531 3788-1495 174 µM -1.43664682369569 0.077664941749777 no 3131 0.0754091858844081 4451 2896655 SGTC_640 3381-0960 37.1 µM -1.43826827960754 0.0774324844506606 no 3132 0.0751789742091598 4509 1745025 SGTC_1098 clofazimine 15.1 µM -1.44131688107107 0.0769968581133911 no 3133 0.0747475901538181 4515 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2900 5328528 85.29 µM -1.44167496169188 0.0769458130911333 no 3134 0.0746970451357686 4458 795359 SGTC_1587 estradiol valerate 56.1 µM -1.45239302178815 0.0754298149110198 no 3135 0.0731961777558783 4516 13791 A steroid. SGTC_429 1112-0049 25.5 µM -1.46234118334655 0.0740431833907377 no 3136 0.0718238691552226 4437 2836170 SGTC_2135 5326629 150.42 µM -1.46687782023734 0.0734173433519804 no 3137 0.071204647561063 4425 5020077 SGTC_1774 st048371 48.465 µM -1.46792325118431 0.0732736988426353 no 3138 0.0710625357965516 4475 4242727 SGTC_2595 hexamethylquercetagetin 100 µM -1.4829253020096 0.0712359915162539 no 3139 0.0690471290823887 4473 386331 SGTC_248 streptozotocin 5.23457 mM -1.48294545186173 0.07123328415141 no 3140 0.0690444520476253 4514 5300 DNA alkylating agent. SGTC_2991 9074669 71.4286 µM -1.4861987219815 0.0707972049514412 no 3141 0.068613282748985 4438 17333109 SGTC_3132 9126706 49.47 µM -1.48908412308284 0.0704121550840242 no 3142 0.0682326090459158 4505 850858 SGTC_3337 9144342 33.5465 µM -1.48964517848354 0.070337470911771 no 3143 0.0681587781265555 4479 17682949 SGTC_1745 st081495 74 µM -1.49101990444765 0.0701547335057758 no 3144 0.0679781345838296 4351 13842402 YBL026W LSM2 SGTC_1077 5-fluorocytosine 377 nM -1.49153105753724 0.0700868809636109 no 3145 0.0679110617344021 4524 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2140 5586273 200 µM -1.49405993125641 0.0697519304750314 no 3146 0.0675799778030081 4465 854421 SGTC_2984 9022109 38.96 µM -1.49614706334502 0.0694764181025945 no 3147 0.0673076679309384 4506 6459207 SGTC_3334 9142812 21.919 µM -1.4971028958465 0.0693505233267538 no 3148 0.0671832431904234 4496 45283678 SGTC_1990 st072050 59.8 µM -1.50019241218423 0.0689447981576883 no 3149 0.0667822841014816 4482 17233948 SGTC_149 3970-0822 46.1 µM -1.50129687977267 0.0688002007254614 no 3150 0.0666393958364167 4469 3114250 YBL034C STU1 SGTC_592 k241-0073 46.5 µM -1.50441726103763 0.0683929422994769 no 3151 0.0662369812913151 4525 4230158 SGTC_2034 5197015 53.07 µM -1.50802580529617 0.0679242931310667 no 3152 0.0657739613054465 4493 780676 SGTC_1844 rapamycin 4 nM -1.50843923602562 0.0678707587352715 no 3153 0.0657210737118575 4346 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3224 9130643 49.47 µM -1.51010862466962 0.0676549239992751 no 3154 0.065507854569597 4509 17644395 SGTC_3275 9138069 49.47 µM -1.51172353270736 0.0674466380121166 no 3155 0.0653021047013441 4547 17617007 SGTC_2893 9048488 25.97 µM -1.51374988594773 0.0671859865376134 no 3156 0.0650446436286822 4533 6467338 SGTC_368 fentichlor 4.58 µM -1.51937344256878 0.0664667034480068 no 3157 0.0643342614305561 4504 7329 A pesticide. SGTC_1074 carmofur 3.8 µM -1.52217298744096 0.0661108564196333 no 3158 0.0639828708228973 4545 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1616 st002734 56.1 µM -1.52233090023807 0.0660908283568999 no 3159 0.0639630946278991 4470 4026101 SGTC_2260 7964312 200 µM -1.52383475488503 0.0659003300974852 no 3160 0.0637749976260805 4529 231951 SGTC_552 k242-0005 476 µM -1.52857114504568 0.0653031356729917 no 3161 0.0631853969178135 4549 4088318 SGTC_2725 haloperidol 53.21 µM -1.5331444403769 0.0647304975995193 no 3162 0.0626201350255135 4480 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1262 0737-0114 49.6 µM -1.53323502435754 0.0647191947776591 no 3163 0.0626089787354192 4521 765919 SGTC_1643 st009866 20.2 µM -1.5344045686968 0.0645733998318506 no 3164 0.0624650771749309 4476 3156273 YOR207C RET1 SGTC_3147 9097027 49.47 µM -1.53536574568397 0.0644537709790643 no 3165 0.0623470064441943 4520 25236841 SGTC_3238 9133470 49.47 µM -1.54012614369356 0.063863824588721 no 3166 0.0617648041223677 4520 3534688 SGTC_2127 5253358 187.912 µM -1.5450201006455 0.0632617133724046 no 3167 0.0611707007256552 4448 20612 SGTC_3310 9130229 44.1445 µM -1.54612172528256 0.0631267901251633 no 3168 0.0610375864299374 4527 7761258 SGTC_960 1222-0186 7.7 µM -1.54667925069506 0.0630585917654086 no 3169 0.0609703044572732 4509 3126296 SGTC_222 nsc-310342 10.666 µM -1.54707555798035 0.063010149045404 no 3170 0.0609225134969434 4542 432556 SGTC_716 1683-5115 658 µM -1.5541703802113 0.0621478076444392 no 3171 0.0600718903882496 4523 723597 SGTC_3262 9137218 49.47 µM -1.55588661158509 0.0619405972937878 no 3172 0.0598675287964811 4518 17650664 SGTC_1613 st002381 52.1 µM -1.55654366929102 0.0618614098603935 no 3173 0.0597894334432177 4522 551167 SGTC_143 4032-1194 15.74 µM -1.56219228718946 0.0611839041083777 no 3174 0.0591213485181682 4553 1806963 SGTC_571 k831-0106 44.2 µM -1.56459997152024 0.0608968904093414 no 3175 0.0588383677911384 4426 4783639 SGTC_256 clotrimazole 625 nM -1.56471182142479 0.0608835827081132 no 3176 0.058825247692982 4472 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_223 busulfan 5 mM -1.56604685300952 0.0607249185257656 no 3177 0.0586688244281239 4522 2478 A DNA alkylator. SGTC_1090 efavirenz 20.7 µM -1.57005442583641 0.0602505734354936 no 3178 0.0582012249581597 4558 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_553 k007-0256 45.7 µM -1.57108722485961 0.060128800342877 no 3179 0.0580811947954614 4576 6287000 SGTC_2342 7990637 118.86 µM -1.5713322251701 0.0600999416581471 no 3180 0.058052749836703 4510 2033102 YER133W GLC7 SGTC_235 0330-0087 5 mM -1.57331488508446 0.0598668021651288 no 3181 0.0578229621824351 4573 46494818 YHR062C RPP1 SGTC_642 0335-0876 158 µM -1.58041520352878 0.059037688146204 no 3182 0.0570059060331304 4578 6812350 SGTC_980 1473-0395 201 µM -1.58899596031251 0.0580477525482223 no 3183 0.0560306523700848 4464 768876 SGTC_305 1682-2595 20.8 µM -1.58977562888745 0.0579584549370498 no 3184 0.0559426945986833 4550 226033 SGTC_2623 humulene 100 µM -1.59018891094973 0.0579111643966474 no 3185 0.055896114658154 4521 6187145 An anti-inflammatory. SGTC_788 1182-0090 188 µM -1.59243529470406 0.0576546481796765 no 3186 0.0556434655336183 4541 5715185 SGTC_1432 4049-0298 68.4 µM -1.59362495535363 0.057519162321631 no 3187 0.05551003080356 4568 741646 SGTC_782 0083-0095 30.5 µM -1.59795545088333 0.0570280929442881 no 3188 0.0550264459758847 4517 3591729 An indicator and reagent. SGTC_3281 9140613 49.47 µM -1.60398658355065 0.0563496814513676 no 3189 0.0543585049749801 4526 16013766 SGTC_86 0417-1630 471.922 µM -1.60474821209077 0.0562644640216432 no 3190 0.0542746135764334 4544 3634867 SGTC_2103 5378138 10 µM -1.60519316315405 0.0562147261771392 no 3191 0.0542256508006414 4619 244142 SGTC_2224 6650123 117.647 µM -1.60626327564202 0.0560952480244255 no 3192 0.0541080378639034 4587 2908370 SGTC_1874 staurosporine 7.6 µM -1.60994799165997 0.0556853805221928 no 3193 0.0537046053439805 4544 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_576 1073-0113 22.7 µM -1.61874230162639 0.054716701103297 no 3194 0.0527513605734259 4619 5439563 SGTC_1938 st074717 56.4 µM -1.62158526968697 0.054406417959324 no 3195 0.0524460893785617 4420 17250979 SGTC_1100 amiodarone 5.07 µM -1.62223548271137 0.0543356492768873 no 3196 0.0523764684722452 4581 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3351 9150312 21.596 µM -1.62787712367277 0.0537246705248212 no 3197 0.0517754714972193 4474 4904905 SGTC_191 3914-0123 66.505 µM -1.63374724184544 0.0530947374767769 no 3198 0.0511559671576257 4624 3144412 SGTC_1295 1013-0063 9.78 µM -1.63381122908507 0.053087903297611 no 3199 0.0511492468908356 4559 6826038 SGTC_2038 4100038 30.985 µM -1.63984074835412 0.0524470419515475 no 3200 0.0505191416117446 4524 3596803 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.64579760930727 0.0518199493675463 no 3201 0.04990271733525 4636 688664 SGTC_2958 9077254 16.72 µM -1.64684809825841 0.0517099825937399 no 3202 0.049794636104768 4566 16457351 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.65072280703431 0.0513059753821969 no 3203 0.0493975942940792 4570 688669 SGTC_1673 st016611 27.3 µM -1.65199410590155 0.0511739683408049 no 3204 0.0492678761993006 4563 5226799 SGTC_1499 4480-0877 67.3 µM -1.66184947857629 0.0501597690200984 no 3205 0.0482714793191738 4571 2861909 SGTC_739 1486-1183 203 µM -1.66457296694713 0.0498823437197518 no 3206 0.0479989911890988 4566 4346692 SGTC_2350 9023895 38.85 µM -1.66761835475189 0.0495735792810508 no 3207 0.047695756120884 4537 2997209 SGTC_2276 7947513 42.08 µM -1.66864743650012 0.0494695886454296 no 3208 0.0475936359726695 4499 2105100 SGTC_503 tyrphostin 8 294 µM -1.66897978670142 0.0494360412580811 no 3209 0.0475606928909454 4585 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_669 0108-0021 26.2 µM -1.66926793117745 0.0494069706908803 no 3210 0.0475321463362694 4575 17201 SGTC_2605 digitonin 300 nM -1.67423663400702 0.048907827302991 no 3211 0.0470420511888022 4562 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2104 5389443 200 µM -1.67686614743084 0.0486453080568274 no 3212 0.0467843296090037 4585 2244536 SGTC_659 k018-0002 107 µM -1.67743093869621 0.0485890689653408 no 3213 0.0467291218174753 4549 6797879 YHR007C ERG11 SGTC_2088 5278280 127.392 µM -1.67942901845827 0.0483905273019774 no 3214 0.0465342308907509 4606 791502 SGTC_536 3852-0578 10.6 µM -1.68368278933263 0.0479700072662671 no 3215 0.0461214946078389 4590 2869208 SGTC_2379 9035213 200 µM -1.68435279870306 0.0479040388059157 no 3216 0.0460567535729386 4589 646551 SGTC_951 1171-0579 82.7 µM -1.68564019705685 0.0477774866835495 no 3217 0.0459325609618388 4515 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1883 5-benzylidenerhodanine 20 µM -1.68971446654843 0.0473787466140224 no 3218 0.04554129712743 4567 1273210 SGTC_90 0870-0863 4.608 µM -1.69026418633334 0.0473251514705535 no 3219 0.045488711744249 4605 1738164 SGTC_1995 st072814 61.1 µM -1.69370852897092 0.0469904489730205 no 3220 0.0451603414822635 4596 5769371 SGTC_154 3389-1638 511.116 µM -1.69744952012304 0.0466290730324116 no 3221 0.0448058535459885 4583 5238686 SGTC_1767 st044992 70.3 µM -1.69755617394749 0.0466188031688201 no 3222 0.0447957802111869 4609 9600693 SGTC_418 lividomycin a 100 µM -1.6981932646594 0.0465574945054129 no 3223 0.0447356456782558 4607 72394 An antibiotic. SGTC_689 0833-0039 98 µM -1.70069022307182 0.0463178301447177 no 3224 0.0445005859905766 4555 5374726 SGTC_1604 st002052 72.4 µM -1.7038369955263 0.0460172068704556 no 3225 0.0442057721403716 4620 6254834 YHR062C RPP1 SGTC_2119 5528445 120.635 µM -1.70894849001444 0.0455322290681152 no 3226 0.0437302456668259 4593 791935 SGTC_2305 7443522 69.23 µM -1.71000124978856 0.045432855588886 no 3227 0.0436328209697886 4491 5415886 SGTC_3269 9137823 49.47 µM -1.71151625626148 0.0452901553091867 no 3228 0.0434929264251739 4543 17682936 SGTC_2078 5212016 200 µM -1.72077576124185 0.0444258103954448 no 3229 0.0426457612205744 4505 1899708 SGTC_1379 2144-0755 36.5 µM -1.72410432031073 0.0441183671274182 no 3230 0.042344506153451 4623 5392327 SGTC_609 0986-0026 86.3 µM -1.7279789375636 0.0437626500697239 no 3231 0.0419960003035878 4596 2848610 SGTC_1236 0330-0013 258 µM -1.73667493010113 0.0429727192910111 no 3232 0.041222282633844 4622 4617066 SGTC_417 st075190 100 µM -1.73844455785587 0.0428133883479825 no 3233 0.0410662555988158 4589 222757 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.74221734709719 0.0424752939553619 no 3234 0.0407352098377977 4587 61125 An anti-inflammatory. SGTC_2521 angolensin 13.4 µM -1.74654191586368 0.0420904120275946 no 3235 0.0403584150851371 4627 821428 A flavenoid. SGTC_1305 1181-0477 144 µM -1.75010205358636 0.0417756862535573 no 3236 0.0400503527402286 4632 6252086 SGTC_2812 7970281 58.44 µM -1.75585277092318 0.0412713353333687 no 3237 0.0395567755307506 4622 2233435 SGTC_537 1334-0398 209 µM -1.75706263494823 0.0411658585101956 no 3238 0.0394535668444436 4621 5846986 SGTC_2678 equilin 100 µM -1.76174839108951 0.0407594116005096 no 3239 0.0390559089467564 4628 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.76956640974329 0.0400885229820382 no 3240 0.0383996993375667 4570 6857784 SGTC_2217 6934799 96.0675 µM -1.77632840066829 0.0395155168433751 no 3241 0.0378394023709802 4598 675606 SGTC_1717 st033143 58.0435 µM -1.7825606610691 0.0389933162558767 no 3242 0.0373289241754001 4615 674616 SGTC_1803 st050068 52.4 µM -1.78538243049929 0.0387587354377295 no 3243 0.0370996532516346 4635 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2813 7971799 71.43 µM -1.79618279673802 0.037871472777919 no 3244 0.0362327249018029 4597 2234054 SGTC_2938 9059746 27.26 µM -1.79899983165533 0.0376427956768578 no 3245 0.0360093536706244 4594 6471769 SGTC_1746 st038117 42 µM -1.80794109415297 0.0369244323145747 no 3246 0.0353078345247486 4646 2898218 SGTC_2040 5100729 123 µM -1.81258329025157 0.0365559099546036 no 3247 0.0349480584801617 4655 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1104 tacrolimus 29.8 µM -1.81895452471209 0.0360550318973867 no 3248 0.0344591841260877 4681 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2381 9035592 200 µM -1.82495630840423 0.0355883531062132 no 3249 0.0340038114444415 4647 4749657 SGTC_2050 5263056 171 µM -1.82735461465984 0.0354032587386391 no 3250 0.0338232342815097 4610 763468 YGL055W OLE1 SGTC_1980 st071811 45.7 µM -1.83223008809618 0.0350294171784637 no 3251 0.0334585739718689 4678 4974850 SGTC_1705 st027868 56.3335 µM -1.84318328475429 0.0342013552466533 no 3252 0.0326511272756768 4574 292948 SGTC_3063 1327-0034 4 µM -1.84590324259341 0.0339982396397476 no 3253 0.0324531278875545 4523 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_857 0438-0306 1.35 µM -1.84650804968948 0.0339532101361167 no 3254 0.0324092358284685 4659 4686136 SGTC_1814 st052110 31.539 µM -1.85027339606139 0.0336739721310031 no 3255 0.0321370775247406 4588 674163 SGTC_1283 0922-0125 16.4 µM -1.85234304684938 0.0335212935028622 no 3256 0.0319882889993405 4637 3360884 SGTC_1447 4239-0816 81.9 µM -1.85375627492083 0.0334173670946441 no 3257 0.0318870183200021 4670 1341554 SGTC_2201 6605497 169.863 µM -1.85434131234825 0.0333744221425504 no 3258 0.0318451726276637 4625 670741 SGTC_326 k292-0812 17.5 µM -1.8592160319468 0.0330183550913509 no 3259 0.0314982616373086 4648 3579357 SGTC_2437 5741531 144.16 µM -1.86309408775916 0.0327373288823624 no 3260 0.0312245149554193 4650 2262990 SGTC_173 1273-0061 2.693 µM -1.86382876291689 0.0326843129245513 no 3261 0.0311728775810501 4588 2847414 YPL266W DIM1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.8886609833242 0.0309335803009051 no 3262 0.0294686349179397 4661 390807 SGTC_40 0327-0103 19.753 µM -1.88874974055183 0.0309274647250286 no 3263 0.0294626850896596 4511 409036 SGTC_2446 5162541 200 µM -1.89066081760193 0.0307960296870238 no 3264 0.029334818033575 4638 1549321 SGTC_414 piperonyl butoxide 100 µM -1.89811014267645 0.030288106331875 no 3265 0.0288407871701143 4664 5794 A potent inhibitor of cytochrome P450. SGTC_221 trifluoperazine 10.304 µM -1.90284264889288 0.0299690469095806 no 3266 0.0285305401450239 4648 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3058 9093861 49.47 µM -1.93259245460112 0.0280265944463955 no 3267 0.0266432113368785 4677 17217477 SGTC_1548 st061468 90.8 µM -1.93494055305824 0.0278778500961518 no 3268 0.0264987955189542 4709 390799 SGTC_104 0074-0074 590.992 µM -1.93899251625879 0.027622718208608 no 3269 0.0262511247165634 4583 3943124 SGTC_467 ro 31-8220 72.8 µM -1.93938466120307 0.027598130419054 no 3270 0.0262272584309219 4648 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_702 1488-0190 94 µM -1.94418331682234 0.027298725774948 no 3271 0.0259366744360831 4696 949357 SGTC_2681 menadione 3.18 µM -1.95021208002266 0.0269264152870149 no 3272 0.0255754232881953 4689 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1333 1482-0047 286 µM -1.96232964924196 0.0261909011317878 no 3273 0.0248620587277632 4690 3811116 SGTC_1057 3448-5381 134 µM -1.97393685006575 0.0255021927415957 no 3274 0.0241944619944274 4665 5497911 SGTC_2320 7373003 200 µM -1.98690594237612 0.0247506821631721 no 3275 0.0234664104978172 4637 5415828 SGTC_1782 st039423 80.636 µM -2.00427954581821 0.0237731364262446 no 3276 0.0225200618371087 4676 2068169 SGTC_1921 5740136 50 µM -2.00490793263538 0.0237383966180286 no 3277 0.0224864452565406 4618 1774243 SGTC_1429 4049-0205 9.46 µM -2.01127089884373 0.0233890238849001 no 3278 0.0221484252907379 4720 22774478 SGTC_2240 6690706 185.951 µM -2.02774042885592 0.0225047692763831 no 3279 0.0212933735510194 4631 805876 SGTC_365 0121-0052 13.6 µM -2.03873334176208 0.0219303799105944 no 3280 0.0207383241092093 4655 3101739 SGTC_2422 chlorphenesin carbamate 384.24 µM -2.03960641424771 0.0218852965270593 no 3281 0.0206947713414749 4638 2724 A muscle relaxant with antifungal properties. SGTC_588 3970-1144 52.9 µM -2.04100736015659 0.0218131185774064 no 3282 0.0206250477616466 4629 1888707 SGTC_1652 st011932 78 µM -2.04586013714772 0.0215646518265662 no 3283 0.0203850666459155 4663 1551076 SGTC_2097 5376186 200 µM -2.05254236340034 0.0212264332408583 no 3284 0.0200584911926698 4702 742755 SGTC_462 ag-879 158 µM -2.05979002770969 0.020864678236567 no 3285 0.019709309166457 4686 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_328 k915-0120 63.5 µM -2.06097415362923 0.0208060734257407 no 3286 0.0196527529775804 4714 6624543 SGTC_1422 4031-0024 15.5 µM -2.06683073339079 0.0205182646144423 no 3287 0.0193750532173395 4668 782427 SGTC_1342 1486-1464 234 µM -2.07626434263688 0.0200617651785365 no 3288 0.0189347546261374 4722 3253938 SGTC_864 0469-0573 172 µM -2.08311862306477 0.0197355105518882 no 3289 0.0186202061315725 4689 689425 SGTC_859 0439-0102 54.6 µM -2.08668076449592 0.0195677433701469 no 3290 0.0184585005897409 4716 610143 SGTC_2160 5660466 132.927 µM -2.09744490426702 0.0190681233135683 no 3291 0.0179771047833461 4687 2859134 SGTC_487 nimodipine 119 µM -2.09924597823952 0.0189855944401348 no 3292 0.0178976114191704 4728 4497 L-type voltage-gated calcium channels inhibitor SGTC_2823 7987624 58.44 µM -2.10236771050111 0.0188432698829447 no 3293 0.017760538712195 4647 2239440 SGTC_3312 9133330 71.43 µM -2.10879418929935 0.0185531329370832 no 3294 0.0174811751976449 4712 17617324 SGTC_2465 5809242 33.21 µM -2.10884138765592 0.0185510162176782 no 3295 0.0174791374108629 4749 2731748 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.11527702090946 0.0182643143594679 no 3296 0.0172031718934949 4707 2724278 An inhibitor of dopamine biosynthesis. SGTC_1596 piperlongumine 63 µM -2.11951395193114 0.018077630871765 no 3297 0.0170235279644354 4714 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_403 arphamenine a 50 µM -2.12064125484213 0.0180282355972358 no 3298 0.0169760018002679 4712 5487158 An arginine aminopeptidase inhibitor. SGTC_3078 9116413 49.47 µM -2.13276577743157 0.01750420747981 no 3299 0.0164719724692361 4688 17177322 SGTC_1030 k029-0042 36.7 µM -2.13505560793643 0.0174067137153039 no 3300 0.0163782340715254 4696 6080581 SGTC_3225 9130819 49.47 µM -2.13878959174864 0.0172487271061388 no 3301 0.016226356396286 4686 4547121 SGTC_1967 st070177 51.4 µM -2.13922444657687 0.0172304080805226 no 3302 0.0162087476059525 4721 5729214 SGTC_1496 4469-0713 57.4 µM -2.14054310518585 0.0171749588578123 no 3303 0.0161554505692771 4740 746691 SGTC_3323 9138564 53.9225 µM -2.14321143035058 0.0170632228433555 no 3304 0.0160480624353117 4723 43912313 YNL103W MET4 SGTC_1475 4092-1048 11.7 µM -2.15404082209589 0.0166160982358082 no 3305 0.0156184853515955 4713 2881759 SGTC_396 dithiazanine 1.25 µM -2.16090038907111 0.0163380978470734 no 3306 0.0153515174264561 4696 10578 An antihelmenthic. SGTC_1463 k081-0032 34.1 µM -2.1713832750911 0.0159209518860586 no 3307 0.0149511060509061 4253 977755 SGTC_2802 7925815 54.55 µM -2.18616459083745 0.0153482937076281 no 3308 0.0144017829112844 4692 1262923 SGTC_707 0865-0008 204 µM -2.18768084986538 0.0152905635831198 no 3309 0.0143464289762048 4756 723043 SGTC_1796 st049173 110.4 µM -2.22191342771226 0.0140359503694698 no 3310 0.0131445783879775 4722 94134 SGTC_1452 4194-0072 190 µM -2.22901559973895 0.0137870743497283 no 3311 0.012906433429211 4740 1343545 SGTC_776 4476-4378 112 µM -2.25922272096094 0.0127706126179227 no 3312 0.0119347670845977 4751 2892008 SGTC_58 0957-0393 9 µM -2.2844442103105 0.0119722293876683 no 3313 0.0111727189147876 4272 6997992 SGTC_353 1988-1175 58.3 µM -2.29756824489767 0.0115741807685158 no 3314 0.0107931873682476 4601 2788357 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -2.30279328111357 0.0114189345054095 no 3315 0.0106452383734507 4771 4213774 SGTC_698 k064-0052 127 µM -2.33957550666393 0.010376377239489 no 3316 0.00965283435392791 4778 5088751 SGTC_1051 3253-3903 78 µM -2.35790149096376 0.00988864052617654 no 3317 0.00918928463952376 4752 5509239 SGTC_2997 9067075 71.4286 µM -2.36893209004228 0.00960482008071306 no 3318 0.00891976434911129 4722 27209819 SGTC_1438 4092-1045 4 µM -2.38327598567155 0.00924641342022881 no 3319 0.00857966226028201 4777 1351342 SGTC_307 1501-1223 22.3 µM -2.40892117924447 0.0086347223323466 no 3320 0.00799987651851511 4762 2830329 SGTC_555 4296-0685 37 µM -2.41468470689166 0.00850223821250041 no 3321 0.00787441784363203 4762 2908540 YHR072W ERG7 SGTC_2328 6201408 200 µM -2.42792843498249 0.00820454815586699 no 3322 0.00759266968530282 4721 2890418 SGTC_2690 usnic acid 100 µM -2.43457871305526 0.00805854754247034 no 3323 0.00745456838249487 4734 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_378 3970-0959 8.33 µM -2.43530644233191 0.00804271039108673 no 3324 0.00743959134786027 4749 6615653 SGTC_193 1273-0060 1.558 µM -2.43814140600213 0.00798127531104794 no 3325 0.00738149889360362 4681 2847393 YHR072W ERG7 SGTC_2453 5731132 22.18 µM -2.46380974122947 0.00744354830897033 no 3326 0.00687345303882211 4760 1362040 SGTC_3311 9131146 2.8755 µM -2.46403521674271 0.00743896981050428 no 3327 0.00686913061614212 4751 4900406 YPR165W RHO1 SGTC_2608 thymoquinone 42.66 µM -2.50881566194461 0.00657741052475779 no 3328 0.00605683406660758 4720 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1800 st050079 29.0735 µM -2.51639905342271 0.00644058940368765 no 3329 0.00592804291222384 4659 3645560 SGTC_357 1325-0123 420 µM -2.52140413604412 0.00635167188964653 no 3330 0.00584437599684731 4757 1098503 SGTC_3194 9111903 49.47 µM -2.54602992070377 0.00592982155461493 no 3331 0.0054477924445829 4747 17087251 SGTC_2618 avocadyne 43.43 µM -2.55944853144055 0.00571057409150877 no 3332 0.00524191893308029 4736 3015189 SGTC_2495 cafestol 54.53 µM -2.56681990829519 0.00559322075990092 no 3333 0.00513179511532428 4745 16667697 An anti-infammatory. SGTC_1974 st069448 26.9 µM -2.58843998477183 0.00526128496038357 no 3334 0.00482058728730485 4766 6323587 YNR016C ACC1 SGTC_682 0kpi-0099 17 µM -2.61811275399767 0.00483427038368915 no 3335 0.00442087919873622 4767 1714895 YML126C ERG13 SGTC_383 2324-0395 7.37 µM -2.63711693535928 0.00457728574004232 no 3336 0.00418070013751103 4767 3146421 SGTC_1317 1273-0028 910 nM -2.69499459224982 0.00386809033432234 no 3337 0.00351948867183544 4772 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1253 0550-0034 176 µM -2.75817060382825 0.00320779459028762 no 3338 0.00290629266257939 4763 5969915 SGTC_1801 st050089 28.441 µM -2.76742143865796 0.00312013143003551 no 3339 0.00282508307863097 4786 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1627 st003713 25.6 µM -2.86613935593099 0.00231036032671995 no 3340 0.00207755646061857 4771 16195070 YER133W GLC7 SGTC_1203 3992-3522 103 µM -2.92763714020383 0.00190748456885134 no 3341 0.0017077419831188 4761 5322312 SGTC_155 k072-0202 43.6 µM -2.95443589456527 0.00175280415351831 no 3342 0.00156620611863044 4782 5857737 SGTC_134 0269-0018 6.916 µM -3.17308913994081 0.000858058453499189 yes 3343 0.000754131043903294 4785 4378915 SGTC_217 ketoconazole 989 nM -3.28872343775307 0.000577868752871161 yes 3344 0.00050321432160318 4730 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_75 0159-0059 199.013 µM -3.33904378522505 0.000484686993799692 yes 3345 0.000420336562017194 4797 5377270 SGTC_1712 st032288 53.4 µM -3.34045817217589 0.000482281187146806 yes 3346 0.00041820139370312 4729 2883011 SGTC_1812 st052057 4.327 µM -3.4925838922869 0.000279397457702752 yes 3347 0.000239185652527715 4803 3645418 SGTC_2497 7-hydroxyflavone 100 µM -3.56201769009248 0.000216246658022836 yes 3348 0.000184007789939387 4792 5281894 SGTC_2696 st077691 74.316 µM -3.66095284899506 0.000148960245106285 yes 3349 0.000125639501726126 4795 757133 SGTC_2582 agaric acid 100 µM -3.8901629991123 6.06682807819442e-05 yes 3350 5.00884548907334e-05 4697 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2270 7924575 90.91 µM -3.90210471977213 5.78174250728608e-05 yes 3351 4.76799415656339e-05 4803 1262135 SGTC_688 0527-0193 473 µM -3.9246768875925 5.27705169719812e-05 yes 3352 4.34231128404026e-05 4808 4007154 SGTC_2511 berberine 10.47 µM -3.95433608346727 4.67689483685061e-05 yes 3353 3.83737331428377e-05 4804 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2780 5215298 71.43 µM -4.41029315289665 6.5942100688603e-06 yes 3354 5.16153862114485e-06 4806 2834131 SGTC_2244 6635614 200 µM -4.65953641345464 2.08180953019239e-06 yes 3355 1.58461165551296e-06 4807 836499 SGTC_2021 4019055 173 µM -4.95259108859571 4.98099531548631e-07 yes 3356 3.66158787615766e-07 4792 44827708 YER133W GLC7