SGTCid condition conc unit YPL088W|YPL088W.score YPL088W|YPL088W.strain.pval YPL088W|YPL088W.strain.significant YPL088W|YPL088W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1404 3909-7820 48.3 µM 5.46828971306464 2.68118782197876e-08 yes 1 2.27199368785767e-08 3 23741373 SGTC_1726 st035556 14.5795 µM 5.29407938882112 6.97205425979511e-08 yes 2 5.98087316415523e-08 16 5919439 SGTC_1373 2887-0003 58.5 µM 5.22114131296322 1.03130260764578e-07 yes 3 8.8911889337016e-08 5 776948 SGTC_3198 9112019 49.47 µM 4.77389226566144 1.01814264878637e-06 yes 4 9.03495360151166e-07 5 45595555 SGTC_733 4069-0007 56.1 µM 4.46322006087015 4.46665002129452e-06 yes 5 4.03685291071668e-06 72 5717425 YNL287W SEC21 SGTC_1370 2001-0092 44.6 µM 4.43998720802561 4.97061451919503e-06 yes 6 4.49821125453863e-06 19 790957 SGTC_520 3584-0023 682 µM 4.22279033027106 1.31747845447639e-05 yes 7 1.20648135835404e-05 21 1340790 SGTC_324 1315-0088 19.6 µM 3.93266765898217 4.51978127819335e-05 yes 8 4.20041736653987e-05 10 6787421 SGTC_1745 st081495 74 µM 3.82181906482386 7.08948509337954e-05 yes 9 6.62354369199851e-05 78 13842402 YBL026W LSM2 SGTC_3207 9114163 49.47 µM 3.74660129731191 9.55937096905086e-05 yes 10 8.96233199925031e-05 38 849233 SGTC_2150 5556613 200 µM 3.6683747935033 0.000129718848203942 yes 11 0.000122048590839706 24 743190 SGTC_3002 9075603 71.4286 µM 3.61782435506841 0.000157527105820339 yes 12 0.000148544947740655 31 20105405 SGTC_154 3389-1638 511.116 µM 3.57226447800147 0.000187281409091063 yes 13 0.000176953862375232 35 5238686 SGTC_2768 sulfasalazine 50.2 µM 3.50784939739373 0.000238396886391464 yes 14 0.00022587235397715 29 5384001 An antioxidant and salicylic acid derivative. SGTC_2220 6782180 200 µM 3.42217723646715 0.000326663492919809 yes 15 0.000310609024195149 12 833803 SGTC_3203 9113543 49.47 µM 3.39589471667586 0.000359315433052789 yes 16 0.000342023328892091 49 17018012 SGTC_1381 2324-0066 62.1 µM 3.38160982692236 0.000378309589516849 yes 17 0.000360312099028952 48 10885928 SGTC_3282 9108498 15.4605 µM 3.35805912539161 0.000411671597906498 yes 18 0.000392459109462297 49 16459645 SGTC_501 nsc-95397 161 µM 3.34543058124489 0.00043066602036224 yes 19 0.00041077460825447 26 262093 SGTC_1075 aripiprazole 15.2 µM 3.33376038622668 0.000448938408397486 yes 20 0.000428402167073196 59 60795 An atypical antipschotic. YIL048W NEO1 SGTC_58 0957-0393 9 µM 3.32728207744476 0.000459389293160095 yes 21 0.000438487760801362 450 6997992 SGTC_3131 9127911 49.47 µM 3.32719861086569 0.000459525401571857 yes 22 0.000438619128321962 48 45595681 SGTC_3291 9121177 71.43 µM 3.25701616913462 0.000588164541514706 yes 23 0.000562950096357766 30 17015612 SGTC_2105 5350118 200 µM 3.21939383878097 0.000670110973385412 yes 24 0.000642309586241659 55 2133313 SGTC_2720 fluspirilene 36.88 µM 3.18882993192903 0.000744303089386877 yes 25 0.000714249460244863 34 3396 An atypical antipsychotic. SGTC_2389 9091542 195.52 µM 3.09596638447113 0.00101863386711059 no 26 0.000980862998236404 78 3626624 YOL127W RPL25 SGTC_2248 tofa 1.1 µM 3.06410811187745 0.0011323343032057 no 27 0.00109159999107595 70 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2628 lathosterol 100 µM 2.97991646886767 0.00149100691254587 no 28 0.00144163497668805 77 6710616 SGTC_3072 9116419 49.47 µM 2.96562997961772 0.00156127331268229 no 29 0.00151031836416059 61 17170162 SGTC_2191 5911152 200 µM 2.96364539719092 0.00157126954246296 no 30 0.00152009199706672 58 2875902 SGTC_2563 tomatine 8.54 µM 2.95056535016032 0.00163862574460356 no 31 0.00158596467775216 116 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_557 1315-0110 16.2 µM 2.93979944667759 0.00169602722251372 no 32 0.00164212374672083 68 6833801 SGTC_1943 st076331 65.2 µM 2.93002636405678 0.00174971418459476 no 33 0.00169466623275441 56 24208415 SGTC_369 0957-0393 4.5 µM 2.92806819026321 0.00176065532476119 no 34 0.00170537616203934 74 6997992 SGTC_404 fumagillin 50 µM 2.91894224737725 0.00181247147521711 no 35 0.00175610643214607 70 12015870 A methionine aminopeptidase binder. SGTC_2654 protoveratrine a 100 µM 2.88745624609771 0.00200206915846833 no 36 0.00194185308664739 45 5702278 A heart drug and vasodilator. SGTC_1765 st044815 90.4 µM 2.88674639984433 0.00200654389852353 no 37 0.00194623915396555 70 645695 SGTC_2663 amphotericin b 100 µM 2.87921160663979 0.00205460464460484 no 38 0.00199335368471849 45 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1074 carmofur 3.8 µM 2.86999460058417 0.00211481478580718 no 39 0.00205239404107215 86 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_905 2-aminofluorene 215 µM 2.86870323431033 0.00212337727717391 no 40 0.00206079156110645 86 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2881 9058953 51.95 µM 2.86059921075969 0.00217783314693438 no 41 0.00211420614550936 81 17122249 SGTC_2962 9082311 13.18 µM 2.86023173819506 0.00218033216123631 no 42 0.00211665769881433 78 16459453 SGTC_2825 7998094 58.44 µM 2.85038271555794 0.00224828693601886 no 43 0.0021833325742113 85 2987815 SGTC_1696 st025591 34.7925 µM 2.83382106300242 0.00236689423880982 no 44 0.00229975393049718 84 2787147 SGTC_1976 st070609 63.5 µM 2.8291036508966 0.00240169950340511 no 45 0.00233392892014157 52 682556 SGTC_2449 5812982 45.77 µM 2.82177520288785 0.00245668838182584 no 46 0.00238793205818156 46 776185 SGTC_357 1325-0123 420 µM 2.80596152801082 0.0025792444794121 no 47 0.0025083340770591 47 1098503 SGTC_2996 9066192 71.4286 µM 2.79000920491975 0.00270844701520714 no 48 0.0026353271525762 106 6472854 SGTC_1545 lovastatin 49.4 µM 2.78997295182145 0.00270874717790991 no 49 0.00263562225322639 103 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3028 9087778 49.47 µM 2.76884791832782 0.00288884962178315 no 50 0.00281274436028495 68 17217395 SGTC_2460 5552655 174.22 µM 2.76623752567257 0.0029118384063563 no 51 0.0028353607065319 98 5401989 SGTC_3156 9099931 49.47 µM 2.75813326754939 0.00298426428996997 no 52 0.00290662464471987 61 18111053 SGTC_2638 epoxomicin 18 µM 2.75573607871718 0.00300599633940757 no 53 0.00292801137525343 85 9915668 A protesome inhibitor. SGTC_351 caspofungin 25 nM 2.75540129991266 0.00300904264331874 no 54 0.00293100939541758 203 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3339 9145883 14.936 µM 2.74277553316869 0.00312598021881572 no 55 0.00304611574096375 65 2030670 SGTC_3170 9103054 49.47 µM 2.69380296501781 0.00361923872130812 no 56 0.00353209557484574 71 16432970 SGTC_2332 7982454 138.89 µM 2.69160147376728 0.00364296944433065 no 57 0.00355549310244799 140 2981748 SGTC_1756 st041558 35.5 µM 2.68849149832488 0.00367673100624925 no 58 0.00358878316865199 52 3955792 SGTC_551 k048-0028 34.9 µM 2.68034392236889 0.00376651506511621 no 59 0.00367732765921788 89 6836383 SGTC_2739 tacrine 100.86 µM 2.66437238949512 0.00394824073641189 no 60 0.0038566062386733 71 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_623 k072-0108 16.9 µM 2.65332203887304 0.00407852920733427 no 61 0.00398518935696379 100 5382803 SGTC_2013 4024628 200 µM 2.65050172278119 0.00411239245139586 no 62 0.00401861587042492 131 5230760 SGTC_2098 5376439 882.5 nM 2.6320052774972 0.00434078153283208 no 63 0.00424412721680065 75 2844116 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.62975710846805 0.00436930020879747 no 64 0.00427229464232805 62 5357218 A potent inhibitor of glutathione S-transferases. SGTC_384 k007-0144 5.16 µM 2.61753288164856 0.00452731808256037 no 65 0.00442839773435626 162 6824886 SGTC_2133 5320837 200 µM 2.60161091398573 0.00474077779257915 no 66 0.00463935279706024 104 2841355 SGTC_3027 9089541 49.47 µM 2.59991964109306 0.00476397128828408 no 67 0.00466227965031277 113 9943819 SGTC_2065 5221596 34.26 µM 2.5947967504741 0.00483484339696206 no 68 0.00473234350839133 89 788581 SGTC_2315 7733312 200 µM 2.57264314953677 0.0051522632544759 no 69 0.00504626046003671 103 726316 SGTC_1808 st050063 61.5 µM 2.56650457569252 0.00524343827247214 no 70 0.00513646349441193 83 4011993 SGTC_2949 9072542 2.23 µM 2.56122660415606 0.00532297561021324 no 71 0.00521516495218818 147 16457352 SGTC_1725 st036284 20.55 µM 2.55753873028289 0.00537918564588519 no 72 0.00527079092217763 123 707914 SGTC_1813 st051246 8.6015 µM 2.55621939630249 0.00539942253897644 no 73 0.00529081887470633 75 5291959 SGTC_2377 9073351 62.6 µM 2.55113068659299 0.00547811220584196 no 74 0.00536870274676561 114 7337946 YHR072W ERG7 SGTC_202 3594-0513 34.79 µM 2.55089339637507 0.00548180630409045 no 75 0.00537235927527268 66 708429 SGTC_691 1548-0686 185 µM 2.50467142013783 0.00624499759830589 no 76 0.00612825984106065 161 46495133 SGTC_2181 6316240 54.2555 µM 2.49242804469617 0.00646230390922676 no 77 0.00634365173220792 113 12779990 SGTC_2397 5161689 200 µM 2.48802376175969 0.00654209575972228 no 78 0.00642275750770017 141 2259942 SGTC_2800 7887935 81.82 µM 2.47755849781421 0.00673519820917572 no 79 0.00661423609608072 132 2961002 SGTC_2647 atorvastatin 60.16 µM 2.47092320436388 0.00686022432551045 no 80 0.00673823777949731 102 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_355 1311-2252 105 µM 2.46977815997512 0.00688200609182305 no 81 0.00675984319890701 127 5338538 SGTC_2868 9035608 32.47 µM 2.46385197307559 0.00699571665374632 no 82 0.00687264326086446 112 6462614 SGTC_2483 5729050 27.16 µM 2.46024769067295 0.00706568316403217 no 83 0.00694205787981748 151 2865180 SGTC_2381 9035592 200 µM 2.43344312812369 0.00760567094703581 no 84 0.00747799236301121 121 4749657 SGTC_470 aa-861 153 µM 2.41265664279265 0.00804911341001558 no 85 0.0079183653639383 182 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3033 9090887 49.47 µM 2.40386804797643 0.00824333670560307 no 86 0.00811131385504937 153 19325384 SGTC_281 1672-3440 14.9 µM 2.40241782557939 0.00827577848308757 no 87 0.0081435467044056 92 6833000 SGTC_2821 7996764 71.43 µM 2.40159102772623 0.00829432426672373 no 88 0.00816197356105695 181 2987135 SGTC_2586 curcumin 80 µM 2.40128957427705 0.00830109519978251 no 89 0.00816870116687085 207 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1578 josamycin 24.2 µM 2.38996030133421 0.0085591057986024 no 90 0.00842509702488167 101 5282165 A P450 substrate. SGTC_2116 5511452 16.8835 µM 2.38276966308837 0.00872649019542695 no 91 0.00859147096099503 122 870744 SGTC_2183 6420625 130.508 µM 2.38238160508433 0.0087356045194662 no 92 0.00860053108668899 215 2897619 SGTC_458 nppb 133 µM 2.34980298409708 0.00953116477370687 no 93 0.00939167507550154 105 4549 A chloride channel blocker. SGTC_1458 k015-0034 6.33 µM 2.34919558718621 0.00954657990565161 no 94 0.00940701057786716 123 3598957 SGTC_1651 st011928 86.1 µM 2.32253848541332 0.0102449327246255 no 95 0.0101019793224033 119 720198 SGTC_2943 9068529 45.32 µM 2.32037158722124 0.0103036106751341 no 96 0.0101603922718333 159 3270634 SGTC_1489 4065-0444 182 µM 2.30121285355724 0.0108352905323539 no 97 0.0106898013569444 127 2877968 SGTC_235 0330-0087 5 mM 2.26952334249802 0.0117671911834531 no 98 0.0116182596865165 166 46494818 YHR062C RPP1 SGTC_2912 7964298 10.93 µM 2.26820823208011 0.0118073240953359 no 99 0.0116582589761345 255 2975850 SGTC_3188 9110789 49.47 µM 2.26714163864479 0.0118399602450978 no 100 0.0116907873255977 176 849217 SGTC_2412 st077135 33.4 µM 2.25340187296713 0.0122674254151782 no 101 0.0121169107753153 174 13258915 SGTC_1743 st037606 46.3785 µM 2.23534615578878 0.012849454327266 no 102 0.0126973160460085 184 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3199 9111318 49.47 µM 2.23218543744765 0.0129537600572293 no 103 0.012801354742788 165 8548020 SGTC_2207 7258803 200 µM 2.23155331312545 0.0129747081881811 no 104 0.012822250103651 107 3666799 SGTC_284 0988-0104 32.6 µM 2.23068901267656 0.0130033978619076 no 105 0.0128508679699618 144 4666532 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.22383487422436 0.0132328631087547 no 106 0.0130797780447134 221 2724 A muscle relaxant with antifungal properties. SGTC_870 0573-2213 57.6 µM 2.21867656585995 0.0134078540436809 no 107 0.013254368209132 134 3916321 SGTC_2069 5228469 200 µM 2.20566364639179 0.0138582089997909 no 108 0.0137037795513397 145 2835210 SGTC_887 0885-0007 9.62 µM 2.20041560335474 0.0140434926579171 no 109 0.0138887108922028 191 5719458 SGTC_2675 theaflavin digallate 100 µM 2.19946582858252 0.0140772519109204 no 110 0.013922408165022 178 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_566 0958-0068 16.5 µM 2.1976332759885 0.0141425867371683 no 111 0.0139876249627973 141 6815365 SGTC_3023 9089636 49.47 µM 2.17979435657899 0.0147923545397773 no 112 0.0146363542282708 128 17249241 SGTC_1226 3909-7979 35.4 µM 2.17606366364718 0.0149314416194288 no 113 0.0147752502376379 202 6615510 SGTC_2001 4023502 57.655 µM 2.17468139293731 0.0149832599137438 no 114 0.0148270001021145 191 108941 YCR052W RSC6 SGTC_1485 3909-9022 254 µM 2.16166994447533 0.0154786527602485 no 115 0.015321812951027 156 714516 SGTC_693 4161-2696 114 µM 2.1585442893776 0.0155997308967494 no 116 0.0154427694238714 117 805759 SGTC_936 3005-4620 401 µM 2.14499171457773 0.016134161542324 no 117 0.015976754724042 206 777207 SGTC_2330 7979373 200 µM 2.14414734994442 0.0161679711184001 no 118 0.0160105410703552 216 1863007 SGTC_352 k048-0007 5.11 µM 2.14352990073635 0.0161927330820468 no 119 0.0160352863885961 249 6811911 SGTC_220 paclitaxel 373.376 µM 2.14283205145709 0.0162207584866982 no 120 0.0160632933286551 121 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_969 1313-0238 134 µM 2.14180253951932 0.0162621792201943 no 121 0.0161046874986749 218 5212874 SGTC_1347 1493-0251 600 nM 2.13517340068275 0.0165310676396803 no 122 0.0163734243884717 201 3986378 SGTC_2741 miltefosine 3.04 µM 2.12606803823524 0.0169065925664581 no 123 0.0167487973770326 144 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1689 st020265 53.493 µM 2.12384939588494 0.0169991916535666 no 124 0.016841369509129 159 5758320 YPR016C TIF6 SGTC_3137 9097352 49.47 µM 2.12334178062597 0.0170204387451832 no 125 0.0168626109958383 241 44120435 SGTC_1254 0550-0035 264 µM 2.11531169017509 0.0173595835916754 no 126 0.0172016953853489 192 15121435 SGTC_1934 st074720 32.6 µM 2.11099968018592 0.0175440681198751 no 127 0.017386169675653 247 17250992 SGTC_1438 4092-1045 4 µM 2.10103223943001 0.0179769292662566 no 128 0.0178190681418743 163 1351342 SGTC_1184 1269-1718 139 µM 2.10059477536416 0.0179961340390103 no 129 0.0178382765357553 168 5403821 SGTC_975 1335-0046 28.5 µM 2.09579753898578 0.0182078840504016 no 130 0.0180500773862994 232 16486740 SGTC_995 3931-2021 34.6 µM 2.09330651125989 0.0183186730407052 no 131 0.0181609008917866 189 730143 SGTC_2102 5377816 72.7585 µM 2.08493169285458 0.0186953653918664 no 132 0.0185377506772992 195 1379702 SGTC_1337 1486-1011 40.3 µM 2.06926535626671 0.0194177401706238 no 133 0.0192605963479664 166 X1337 SGTC_2481 5478948 45.16 µM 2.06821065603814 0.019467212970947 no 134 0.0193101093356078 228 77792 SGTC_2696 st077691 74.316 µM 2.05701591601213 0.0199989565713756 no 135 0.0198423474553792 192 757133 SGTC_1539 benzyladenosine 56 µM 2.04398890930285 0.02063319447952 no 136 0.0204773214053212 179 92208 A nucleotide analog. SGTC_1357 1503-1303 39.5 µM 2.04316810866431 0.0206737205409932 no 137 0.0205178997786125 238 292895 SGTC_1 0258-0098 57.368 µM 2.03461634593174 0.0210999785860607 no 138 0.0209447456699807 163 6790032 YDR047W HEM12 SGTC_2291 7917025 104.35 µM 2.03261081312258 0.0212010127078141 no 139 0.0210459290932286 265 2964612 SGTC_1001 4048-4355 44.4 µM 2.03229629093326 0.0212168946718046 no 140 0.0210618348703952 211 21824233 SGTC_2066 5222451 176 µM 2.03227651074753 0.021217893818967 no 141 0.0210628355187803 271 2281147 SGTC_552 k242-0005 476 µM 2.0307035289182 0.0212974766256157 no 142 0.0211425390818026 184 4088318 SGTC_429 1112-0049 25.5 µM 2.01643093750761 0.0220311823906223 no 143 0.0218774665806845 235 2836170 SGTC_499 genistein 192 µM 2.00627806472192 0.0225659994491595 no 144 0.0224132944983171 125 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_618 k072-0232 33.2 µM 2.0021066175368 0.0227888874931701 no 145 0.0226366329821392 194 5872756 YGL099W LSG1 SGTC_2143 5623677 140.463 µM 1.98715885865794 0.0236028654465078 no 146 0.0234523976988155 151 5375313 SGTC_2691 st077356 60.2 µM 1.98505973616329 0.0237191076613315 no 147 0.0235689128844702 239 2839272 SGTC_1034 k072-0165 12.7 µM 1.98504830727075 0.0237197418694442 no 148 0.0235695485939044 253 5835461 SGTC_156 3474-0145 5.642 µM 1.97621434563539 0.0242142363095437 no 149 0.0240652529013143 256 2265471 SGTC_1203 3992-3522 103 µM 1.97008326324085 0.024562499260589 no 150 0.024414414372343 256 5322312 SGTC_2346 9031566 143.75 µM 1.95878395647412 0.0252153462685006 no 151 0.025069046621838 208 4771086 SGTC_2407 paclitaxel 400 µM 1.95412389299836 0.0254887971163725 no 152 0.0253432835390241 276 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.95000334896251 0.0257326537984383 no 153 0.0255878599418539 250 6710655 SGTC_1266 0828-0227 32.9 µM 1.94609610622049 0.0259656878980003 no 154 0.0258215981211919 237 3913820 SGTC_1228 0124-0032 52.5 µM 1.94397683343634 0.0260928214160723 no 155 0.025949122408561 246 X1228 SGTC_492 tmb-8 126 µM 1.9364806409163 0.0265466967598389 no 156 0.0264044306620669 94 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1086 cerivastatin 2.18 µM 1.9337982983193 0.0267107000114006 no 157 0.0265689660549342 186 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1902 st060212 70.5 µM 1.92649206976144 0.0271617123999304 no 158 0.0270214805534156 227 688944 SGTC_3110 9122132 49.47 µM 1.92564300238481 0.0272145349214946 no 159 0.0270744826788132 212 918317 SGTC_1457 k015-0032 57.3 µM 1.92466643932514 0.0272753951962902 no 160 0.0271355508347068 280 4302660 SGTC_2974 9094440 9.66 µM 1.92153779069258 0.0274711403108747 no 161 0.0273319714072178 289 25236134 SGTC_1476 4112-3294 3.34 µM 1.9202208748267 0.0275538832231368 no 162 0.0274150029668614 217 704369 SGTC_519 k048-0011 62.8 µM 1.91632064573818 0.0278001574919675 no 163 0.0276621472680683 250 6836379 SGTC_17 0960-0276 49.807 µM 1.91625526803154 0.0278043012497064 no 164 0.0276663058037953 291 6821114 SGTC_1146 3579-1023 7 µM 1.91586594600668 0.0278289878444493 no 165 0.027691080533926 278 X1146 SGTC_804 1595-0054 20.9 µM 1.91483212209204 0.0278946304239605 no 166 0.0277569582587636 245 761523 Stimulates phospholipase C. SGTC_2267 7931562 200 µM 1.91304927292378 0.0280081353029983 no 167 0.0278708724370283 219 934880 SGTC_1193 1488-0126 41.5 µM 1.9096327600802 0.0282267220546394 no 168 0.0280902570010653 269 1384710 SGTC_1968 st069590 43.6 µM 1.9076876169787 0.0283518044530443 no 169 0.0282158015733546 221 6384066 SGTC_2815 7968870 71.43 µM 1.89820851961549 0.0289679765327438 no 170 0.0288343094833752 296 2977326 YHR190W ERG9 SGTC_2855 9016525 58.44 µM 1.89762487782701 0.029006276072898 no 171 0.028872757419776 250 43811474 SGTC_2342 7990637 118.86 µM 1.88254989523334 0.0300101940688722 no 172 0.0298806960128219 282 2033102 YER133W GLC7 SGTC_3244 9134489 49.47 µM 1.88128862954253 0.0300954785235267 no 173 0.0299663334546851 256 16584271 SGTC_769 0302-0231 76 µM 1.88096955023271 0.0301170858953871 no 174 0.0299880305380242 335 571869 YER009W NTF2 SGTC_1905 st060207 84.5 µM 1.87856862557562 0.0302800842143871 no 175 0.0301517092412106 214 1948547 SGTC_2318 6029776 164 µM 1.8720636833379 0.0307253805926393 no 176 0.0305988967886376 281 818325 SGTC_2002 4023503 131 µM 1.86982971527292 0.0308795523341381 no 177 0.0307537342445973 340 4736863 YCR052W RSC6 SGTC_2255 7941087 197.44 µM 1.86539460795882 0.0311875278991136 no 178 0.0310630563061005 296 935561 SGTC_3112 9123419 49.47 µM 1.85528287283401 0.0318991978415304 no 179 0.031777921337856 278 17015854 SGTC_1386 3228-0095 33.8 µM 1.85131374899185 0.0321821887438623 no 180 0.0320622146245764 246 870181 SGTC_624 k048-0052 28 µM 1.85088384061477 0.0322129643899777 no 181 0.0320931329857706 247 6835531 SGTC_2224 6650123 117.647 µM 1.84776428733428 0.0324370107720703 no 182 0.0323182246672587 194 2908370 SGTC_1302 1159-0335 255 µM 1.84643278008749 0.0325330303499316 no 183 0.0324146956239539 246 649284 SGTC_3231 9132313 49.47 µM 1.84320885633361 0.0327664899818174 no 184 0.0326492611636406 237 4905967 SGTC_2353 9059630 146.67 µM 1.83749781661733 0.033183443480739 no 185 0.0330682192498607 218 4779114 SGTC_263 alizarin 107.927 µM 1.83029912335469 0.0337152247959646 no 186 0.0336026112046898 371 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2427 5545055 42.75 µM 1.82742005229376 0.0339298613163481 no 187 0.0338183183229153 295 5372858 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.82389696552337 0.0341940373854569 no 188 0.0340838252644615 292 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1012 4112-3522 18 µM 1.82069517920086 0.0344355853379502 no 189 0.0343266027021193 289 3112398 SGTC_210 3551-0445 56.827 µM 1.82034415957265 0.034462151896266 no 190 0.0343533052153133 303 2865180 YOR207C RET1 SGTC_1981 st071826 47 µM 1.81916727595901 0.0345513460195003 no 191 0.0344429568453833 229 11838600 SGTC_1547 harmine 94.2 µM 1.81784989055156 0.0346514134033456 no 192 0.0345435394372184 352 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_583 1488-1091 88.9 µM 1.81560629407213 0.0348223827289862 no 193 0.0347153937152666 340 4303273 SGTC_894 0960-0238 55.9 µM 1.81458491727446 0.0349004440423155 no 194 0.0347938610433522 237 6741907 YDL195W SEC31 SGTC_1842 st055362 61.2 µM 1.81252246794794 0.0350585098700236 no 195 0.0349527527569173 313 676032 SGTC_1852 st056254 31.4 µM 1.81042946686669 0.0352195172904648 no 196 0.035114606568797 252 442583 SGTC_1525 8-methoxypsoralen 92.5 µM 1.81017355192565 0.0352392455054591 no 197 0.035134438847013 324 4114 Related to psoralen; DNA damaging agent. SGTC_139 0099-0334 718.624 µM 1.80872960828351 0.0353507275469537 no 198 0.0352465103899608 339 97690 SGTC_1779 st039427 55 µM 1.80223885111146 0.0358554350062708 no 199 0.0357539172931849 345 1124498 SGTC_1529 apigenin 74 µM 1.80050845813679 0.0359909789122166 no 200 0.0358901946285252 311 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_773 4358-1457 44.6 µM 1.79984495727746 0.0360430629790568 no 201 0.0359425614685648 340 1186886 SGTC_615 k087-0205 167 µM 1.79893801084984 0.0361143570912238 no 202 0.036014243497228 254 9642773 SGTC_1301 naphtanilide LB 4.81 µM 1.78888590605505 0.0369123017389749 no 203 0.0368165960249091 274 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2178 5812956 200 µM 1.78265015013876 0.0374145055735016 no 204 0.0373216353898384 256 5403383 SGTC_2406 ethylparaben 405.7 µM 1.78224269814729 0.0374475134907032 no 205 0.0373548313095389 269 8434 A possible steroid mimic. SGTC_3245 9134821 49.47 µM 1.77826433314168 0.0377710544854963 no 206 0.0376802256554023 306 17014901 SGTC_145 3737-0113 38.366 µM 1.7732612817706 0.0381811630842569 no 207 0.0380927108106721 403 6849351 SGTC_963 1269-2853 151 µM 1.76963102537277 0.0384810090526035 no 208 0.03839431347229 291 3668223 SGTC_215 1287-0124 461.5 µM 1.76469437923246 0.0388918347016651 no 209 0.0388075718771221 202 5560863 SGTC_617 3770-0098 35 µM 1.75051853551448 0.0400914309713043 no 210 0.0400144393041722 296 5962639 SGTC_612 0302-0167 22.4 µM 1.75030328131426 0.040109875462606 no 211 0.0400329975081257 373 235821 SGTC_952 1185-0122 232 µM 1.74904263757635 0.040218034733845 no 212 0.0401418247451477 317 678600 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.74689434959505 0.0404028968643376 no 213 0.0403278330738922 358 442882 SGTC_1031 k035-0009 16 µM 1.74620596586779 0.0404622786666987 no 214 0.0403875842698189 344 5180959 SGTC_457 grayanotoxin iii 135 µM 1.74507968192131 0.0405595876946311 no 215 0.0404854998901077 413 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_794 k038-0031 316 µM 1.74069932049673 0.0409398510996656 no 216 0.0408681487317874 410 6624242 SGTC_2770 toltrazuril 17.5 µM 1.74055249445612 0.0409526471309407 no 217 0.0408810254473148 318 68591 Kills coccidiodes. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.73943629908382 0.0410500307436037 no 218 0.0409790239807933 311 390807 SGTC_976 1348-1067 47.6 µM 1.73864330930356 0.0411193299916844 no 219 0.0410487617555942 338 5310671 YGL099W LSG1 SGTC_2000 st075254 36.4 µM 1.7321643149002 0.041689088672095 no 220 0.0416221553501164 251 17234175 SGTC_1238 0333-0287 48.8 µM 1.7224917517247 0.0425515703347693 no 221 0.0424902378449397 309 7226 SGTC_723 4182-0001 115 µM 1.72235642705671 0.0425637385212338 no 222 0.042502485885081 306 744821 YLR208W SEC13 SGTC_3109 9122853 49.47 µM 1.72176343199046 0.0426170929110728 no 223 0.0425561906846055 290 1234709 SGTC_99 0109-0120 622.8 µM 1.71681586070865 0.0430643584820043 no 224 0.0430064110225176 273 759414 SGTC_2516 gossypol 71.55 µM 1.71594319309665 0.0431436405650667 no 225 0.0430862200743439 326 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2596 sinensetin 100 µM 1.71358240282639 0.0433587099780957 no 226 0.0433027238296918 317 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1933 st074711 15.9 µM 1.7122409582281 0.0434813015445191 no 227 0.0434261361281482 341 17250958 SGTC_151 3013-0144 2.285 µM 1.70889881528039 0.0437879495322255 no 228 0.0437348470082568 329 906558 YHR107C CDC12 SGTC_3211 9128781 49.47 µM 1.70036862242626 0.044578524522237 no 229 0.0445308050206486 369 17194361 SGTC_3181 9108277 49.47 µM 1.69909628213701 0.0446974238569977 no 230 0.0446505219005087 310 17097298 SGTC_585 0kpi-0023 191 µM 1.69412199023856 0.0451647211938793 no 231 0.0451210522353007 299 64601 SGTC_2194 5927483 104.545 µM 1.69372877070348 0.0452018282493994 no 232 0.0451584173665825 354 760979 SGTC_170 4197-0004 226 µM 1.69334376635293 0.0452381838223874 no 233 0.0451950259805224 283 218692 SGTC_616 4092-0450 108 µM 1.68482990764256 0.0460481678985623 no 234 0.0460106964550186 357 787165 SGTC_1936 st074407 74.3 µM 1.68289578964417 0.0462337887037298 no 235 0.0461976334048107 384 809813 SGTC_972 1319-0219 195 µM 1.68164563968084 0.0463540872282415 no 236 0.0463187874699176 341 23903702 SGTC_280 3448-3607 3.04 µM 1.68123108476867 0.0463940341553402 no 237 0.046359018936522 295 626179 SGTC_3062 9077494 49.47 µM 1.67822141497107 0.0466848782227097 no 238 0.046651941318776 332 16459633 SGTC_3103 9120822 49.47 µM 1.67706585135219 0.0467969358249271 no 239 0.0467648027702683 336 17141819 SGTC_3105 9121040 49.47 µM 1.6741248398082 0.0470831058530833 no 240 0.0470530334413852 150 41448907 SGTC_652 0437-0092 114 µM 1.67079972922133 0.0474083380180075 no 241 0.0473806210281696 295 3091274 SGTC_632 0781-2353 4.65 µM 1.66943902522588 0.0475419477144767 no 242 0.0475152024962434 366 6811515 YHR007C ERG11 SGTC_1554 st069299 38.7 µM 1.66905315173215 0.0475798920977009 no 243 0.0475534232937651 342 24207999 SGTC_216 k038-0035 28.382 µM 1.66718642444781 0.0477637970257424 no 244 0.0477386706463803 298 4444231 YPR107C YTH1 SGTC_2149 5554786 194.827 µM 1.66481875201741 0.0479978720200207 no 245 0.0479744607986588 384 745063 YPR165W RHO1 SGTC_27 0485-0001 32.618 µM 1.65881425727477 0.048595611814467 no 246 0.0485766132515019 227 2054479 SGTC_2536 dehydroabietamide 32.04 µM 1.65426414884957 0.0490525211222294 no 247 0.0490369269669262 369 3983547 SGTC_2874 9043904 71.43 µM 1.65326422812613 0.0491533889007467 no 248 0.0491385499318983 276 4463428 SGTC_622 1348-1566 26.3 µM 1.65320811966255 0.0491590537904518 no 249 0.0491442572727259 377 7340407 SGTC_1068 loratadine 26.9 µM 1.63967742547227 0.0505404510945672 no 250 0.0505361275467477 339 3957 A H1 histamine antagonist. SGTC_2155 5570423 76 µM 1.63846075022758 0.0506661662825161 no 251 0.0506628076506366 337 797402 SGTC_3101 9120531 49.47 µM 1.63394667919747 0.0511347684078209 no 252 0.0511350235455623 378 24824904 SGTC_640 3381-0960 37.1 µM 1.63339865109693 0.0511918927811865 no 253 0.0511925902793953 350 1745025 SGTC_20 0481-0013 4.944 µM 1.63236663125831 0.0512996044545258 no 254 0.0513011371264772 358 182045 SGTC_802 4112-3352 742 µM 1.62960631730319 0.0515885839237951 no 255 0.0515923641924367 396 704594 SGTC_359 0081-0058 15.9 µM 1.62943323287131 0.0516067473082482 no 256 0.0516106691813546 349 3494159 SGTC_1676 st018489 23.4 µM 1.62908180617399 0.051643641473018 no 257 0.0516478511001733 384 3696235 SGTC_2297 7971671 152.32 µM 1.62806606724056 0.0517503956665459 no 258 0.0517554388340707 337 909016 SGTC_2293 7624732 200 µM 1.62300569160006 0.0522848574630711 no 259 0.0522940940907572 341 894453 SGTC_1772 st048439 82.2 µM 1.62114512132304 0.0524824638990443 no 260 0.0524932595056796 391 2927068 YDL195W SEC31 SGTC_1064 honokiol 6.76 µM 1.61795205533632 0.0528229725923445 no 261 0.0528364652825436 366 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_128 0906-2981 13.371 µM 1.61793182174814 0.0528251358777872 no 262 0.0528386457459228 311 6740226 SGTC_2869 9037858 32.47 µM 1.60904727100236 0.0537818433495102 no 263 0.0538030028424333 303 27187042 SGTC_2259 7964009 200 µM 1.60789635163814 0.0539067744070224 no 264 0.0539289405146488 339 313134 SGTC_2576 guaiol 23.12 µM 1.60768141322104 0.0539301311824766 no 265 0.053952485679369 391 227829 SGTC_542 3381-0244 89.3 µM 1.60578369279032 0.0541366991376152 no 266 0.0541607224238817 424 1112843 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.6042754239489 0.0543013212583727 no 267 0.0543266778913423 347 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1172 0370-0043 85 µM 1.60251012427469 0.0544945001426321 no 268 0.0545214252688598 333 376585 SGTC_1957 st077035 62.4 µM 1.59605656628564 0.0552053500607937 no 269 0.0552380823409756 343 705593 SGTC_2832 7992762 51.95 µM 1.59599581092 0.0552120768096681 no 270 0.0552448643072523 335 2985177 SGTC_2243 6634756 200 µM 1.59594597107353 0.0552175954909489 no 271 0.0552504282930338 308 885676 SGTC_3214 9129694 49.47 µM 1.59476441584614 0.0553485547337688 no 272 0.0553824635914412 356 17158655 SGTC_1154 4088-0362 150 µM 1.59143969773038 0.0557183705990591 no 273 0.0557553281596331 442 6618304 SGTC_810 3825-7150 143 µM 1.58789646021326 0.05611463641092 no 274 0.0561548770377646 374 22330411 YGL099W LSG1 SGTC_2908 7930301 100 µM 1.58310891041241 0.056653588884894 no 275 0.0566983215270214 413 2223178 SGTC_1647 st011722 22.4 µM 1.57661323877249 0.0573913413845581 no 276 0.0574422723405593 349 2854783 SGTC_1180 1193-0155 285 µM 1.55930400850671 0.0593941837774056 no 277 0.0594622217205327 388 2921347 SGTC_367 0335-0881 7.1 µM 1.55677316462294 0.0596915633456176 no 278 0.0597621753235697 434 23828853 SGTC_2844 9010103 25.97 µM 1.55420440046752 0.0599945903502702 no 279 0.0600678340998707 433 2480525 SGTC_3049 9092223 49.47 µM 1.55210133496866 0.0602435764921611 no 280 0.0603189893143704 363 8623917 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.54987051922292 0.060508570531423 no 281 0.0605862984200734 404 5282309 SGTC_2472 5377652 49.4 µM 1.54490201049006 0.0611020466326283 no 282 0.0611849835468192 454 1610903 SGTC_564 3555-0129 330 µM 1.54326415738317 0.0612986780733593 no 283 0.0613833481799487 301 563260 SGTC_673 1082-0474 110 µM 1.54054550393862 0.0616261553027953 no 284 0.0617137199569011 489 3098046 SGTC_1426 4048-4480 71.7 µM 1.53723755048485 0.0620264575719508 no 285 0.0621175739904512 408 14224343 SGTC_577 r071-0003 38.6 µM 1.53198812651057 0.0626658622056838 no 286 0.0627626823944996 544 4568517 YMR134W ERG29 SGTC_1753 st043925 64 µM 1.5312387880992 0.0627575526757699 no 287 0.0628551938338978 431 670181 SGTC_2132 5317594 122.667 µM 1.52807501844986 0.0631458304968095 no 288 0.0632469565840417 350 794577 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.52672196732708 0.0633124555197936 no 289 0.0634150812733969 389 97141 SGTC_1072 oxiconazole 14.9 nM 1.52200452956933 0.0638960749270106 no 290 0.0640039728703714 447 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2968 9090663 33.37 µM 1.52099541372543 0.0640214595733023 no 291 0.064130494118708 417 25236811 SGTC_2780 5215298 71.43 µM 1.51691991809262 0.0645297953802493 no 292 0.0646434520425672 435 2834131 SGTC_774 k060-0086 136 µM 1.51661480356845 0.0645679780571908 no 293 0.0646819828091278 472 5911235 SGTC_3326 9140064 16.379 µM 1.51486056861668 0.0647878473390639 no 294 0.0649038589678395 385 1868434 SGTC_2296 7971656 126.45 µM 1.51469130464007 0.0648090929724734 no 295 0.0649252987438158 434 666570 SGTC_842 0271-0008 11.1 µM 1.51198229067234 0.0651498589004342 no 296 0.0652691838912404 449 1221709 SGTC_2588 indole-3-carbinol 100 µM 1.5054586506079 0.0659761702482496 no 297 0.0661030999862816 468 3712 Induces cell cycle arrest. SGTC_2166 5933061 31.504 µM 1.50253214259681 0.0663494823701612 no 298 0.0664798666349662 421 2877375 SGTC_2113 5491891 107.031 µM 1.50210944830334 0.0664035371504406 no 299 0.0665344225858735 441 789979 SGTC_911 3456-4043 236 µM 1.49969687669963 0.0667127133697647 no 300 0.0668464699960845 445 914281 SGTC_2499 avocadenofuran 51.48 µM 1.49522362065788 0.06728891688755 no 301 0.0674280454656668 458 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2598 perillyl alcohol 100 µM 1.49458918544082 0.067370949562035 no 302 0.067510845136981 434 10819 An apoptosis inducer. SGTC_2941 9056145 11.23 µM 1.48150726120093 0.0690797304526607 no 303 0.0692357257121122 342 2119517 SGTC_1454 4239-0054 42.6 µM 1.47642645923621 0.0697523266324361 no 304 0.0699147219944068 488 1340767 SGTC_2314 7727897 200 µM 1.47569439838403 0.0698496508570514 no 305 0.0700129752062045 416 900724 SGTC_61 0978-8327 98.565 µM 1.47312858189443 0.0701915899052887 no 306 0.0703581839174195 449 6150059 YHR072W ERG7 SGTC_433 pimozide 108 µM 1.47160162632156 0.070395693148461 no 307 0.070564243073038 334 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2896 9052656 71.43 µM 1.47022113330636 0.0705806116940192 no 308 0.0707509364148274 582 6469436 SGTC_2708 st078559 56 µM 1.47005913819098 0.0706023355702869 no 309 0.07077286896059 327 17250902 SGTC_836 0330-0104 1.35 µM 1.46428716614061 0.0713797271521312 no 310 0.0715577511388709 437 46494820 SGTC_275 trichlorophene 5.69 µM 1.46393192465171 0.0714277862259878 no 311 0.071606274769123 625 62616 SGTC_455 paf C-16 10 µM 1.46088285268282 0.0718413037624139 no 312 0.0720237965753704 410 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_567 1080-0542 68.4 µM 1.45825658453275 0.0721989499314156 no 313 0.0723849161275788 401 5950415 SGTC_3147 9097027 49.47 µM 1.45310947062033 0.0729038417846957 no 314 0.0730966809810331 453 25236841 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.45310876692693 0.072903938513648 no 315 0.0730967786555956 440 641818 YHR062C RPP1 SGTC_2095 5432005 200 µM 1.45227424582674 0.073018720061541 no 316 0.0732126827666339 402 783734 SGTC_1022 4477-0945 21.3 µM 1.45184151948232 0.0730782924561352 no 317 0.0732728381511961 461 4648966 SGTC_2186 6124449 200 µM 1.45120260723686 0.0731663179568763 no 318 0.0733617255555625 418 3834182 YLR033W RSC58 SGTC_1786 berberine 21.6 µM 1.44138564977958 0.0745290602008514 no 319 0.0747378810541573 473 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1874 staurosporine 7.6 µM 1.43980897059823 0.0747497212677771 no 320 0.0749607262638122 479 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1057 3448-5381 134 µM 1.43874065760595 0.0748995180198871 no 321 0.0751120076463142 478 5497911 SGTC_2321 7390090 138.78 µM 1.43739661093823 0.0750883027541288 no 322 0.0753026656167817 407 649046 SGTC_1395 3486-0190 4.35 µM 1.43243546456716 0.0757882877671146 no 323 0.0760096175321241 482 6748079 SGTC_2126 5251174 33.877 µM 1.43184380832929 0.0758720971757789 no 324 0.0760942633159269 560 790722 SGTC_2666 tannic acid 100 µM 1.43165854621903 0.0758983544664703 no 325 0.0761207827383476 502 16134267 A thiamine antagonist. SGTC_1214 0358-0031 63.7 µM 1.42863523703923 0.0763278280465296 no 326 0.0765545504067306 468 4301366 SGTC_3166 9102297 49.47 µM 1.42836219682411 0.0763667054006407 no 327 0.0765938170846986 488 25237072 SGTC_1581 himbacine 57.9 µM 1.42680297686118 0.07658900667444 no 328 0.0768183464501088 490 5281825 An alkaloid muscarinic receptor antagonist. SGTC_916 4466-0038 42 nM 1.42623109893745 0.0766706637651241 no 329 0.0769008228012777 610 5722064 YGL116W CDC20 SGTC_582 0987-0078 156 µM 1.42398976613051 0.0769913366888039 no 330 0.0772247172804336 621 1625765 SGTC_1261 0712-0010 12.7 µM 1.42391988795328 0.0770013506906376 no 331 0.0772348319944087 506 2840123 SGTC_2221 6807166 181.081 µM 1.42124314095035 0.0773856918231153 no 332 0.0776230434660547 364 674925 SGTC_3193 9111931 49.47 µM 1.41979016800755 0.0775949263858496 no 333 0.0778343890886773 467 17087244 SGTC_1733 st037357 54.9 µM 1.41574236425588 0.0781800931927224 no 334 0.0784254749528755 510 1272339 YGL099W LSG1 SGTC_426 0988-0037 14.6 µM 1.41493910671797 0.0782966123247891 no 335 0.0785431753251545 532 5383008 SGTC_2393 9031399 185.94 µM 1.41398285398351 0.0784354963226935 no 336 0.0786834684267807 474 1526623 YDL150W RPC53 SGTC_718 1130-0073 349 µM 1.40802732732952 0.0793046706584782 no 337 0.079561489122812 502 6740020 SGTC_1221 2958-7315 257 µM 1.40405879269481 0.0798878905009625 no 338 0.0801506714917958 479 4562705 SGTC_2070 5230947 200 µM 1.40376050898315 0.0799318572906005 no 339 0.0801950886305386 487 2835538 SGTC_629 3448-6466 76.7 µM 1.4028534424447 0.0800656706253208 no 340 0.0803302733417464 504 573744 SGTC_869 0564-0080 44.1 µM 1.40211759480405 0.0801743495719094 no 341 0.0804400668891943 498 6843321 SGTC_1295 1013-0063 9.78 µM 1.4002842311088 0.0804456080134614 no 342 0.0807141104969017 489 6826038 SGTC_2927 9011802 47.9 µM 1.39795596567291 0.0807910891700805 no 343 0.0810631454186167 471 43912568 SGTC_606 k015-0008 38.6 µM 1.39434130540693 0.081329670880574 no 344 0.0816072816432824 516 1970475 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.39214097960095 0.0816588413335935 no 345 0.0819398554924096 514 16486 A toxic proline analog. SGTC_1013 4112-3890 241 µM 1.39189628317953 0.0816955100814422 no 346 0.0819769037706737 511 705171 SGTC_21 0849-0113 22.993 µM 1.38593136388934 0.0825932212778251 no 347 0.0828839313378381 507 1560156 SGTC_1472 k841-0093 193 µM 1.38474981437172 0.0827719203995822 no 348 0.0830644906373316 531 X1472 SGTC_3257 9139206 32.98 µM 1.38353105517753 0.0829565518163147 no 349 0.0832510459388696 394 4910041 SGTC_440 fluspirilene 35.1 µM 1.38326706080728 0.0829965854558016 no 350 0.0832914969957297 500 3396 An atypical antipsychotic. SGTC_3255 9139072 49.47 µM 1.38088829208172 0.0833579713839686 no 351 0.0836566551722781 488 17646060 SGTC_1522 st012842 45.6 µM 1.38077664078351 0.0833749626243125 no 352 0.0836738239575078 456 3491067 YOR116C RPO31 SGTC_903 1134-0042 114 µM 1.37950212222423 0.0835691050351411 no 353 0.0838699961796008 484 701009 SGTC_750 4073-0104 132 µM 1.37947582102284 0.083573114968226 no 354 0.0838740480604227 388 22330957 SGTC_812 4251-0442 148 µM 1.37571148711969 0.0841485251090379 no 355 0.0844554870604685 462 5723007 SGTC_783 0848-0141 92.7 µM 1.37286363940068 0.0845858148555432 no 356 0.0848973710654576 473 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.37218150475375 0.0846908098778561 no 357 0.0850034707896786 483 140250 A respiratory chain inhibitor. SGTC_1947 st076332 61.6 µM 1.37185124456553 0.0847416790442339 no 358 0.085054875396616 411 24208416 SGTC_2354 9060492 162 µM 1.37115541569873 0.0848489308439428 no 359 0.0851632565856828 555 6471895 SGTC_1672 st016598 6.51 µM 1.36846418420803 0.0852647027610254 no 360 0.085583412748463 520 4665860 YNL267W PIK1 SGTC_1227 3909-8010 46.6 µM 1.36686311747726 0.0855127767857965 no 361 0.0858341072372605 470 15982272 SGTC_2206 7254556 146.969 µM 1.36482815453966 0.0858288595674288 no 362 0.0861535337852587 434 4398905 SGTC_1018 4259-0013 28.1 µM 1.35987188605709 0.0866023546757553 no 363 0.0869352345148335 493 6801262 SGTC_497 capsazepine 133 µM 1.35920689762281 0.0867065306285885 no 364 0.0870405180927637 485 2733484 A calcium channel blocker. SGTC_1446 4239-0190 62 µM 1.35832046327727 0.0868455435086139 no 365 0.0871810099016463 549 1340085 SGTC_751 0833-0568 350 µM 1.35624424891941 0.0871717923774543 no 366 0.0875107337283063 506 6954252 SGTC_3069 9117009 49.47 µM 1.35533404622275 0.0873151065733209 no 367 0.0876555761939073 385 41904981 SGTC_373 0844-0104 25.9 µM 1.35522844408405 0.0873317453338288 no 368 0.0876723924570845 542 5375804 SGTC_2276 7947513 42.08 µM 1.35234250630962 0.0877873727873673 no 369 0.0881328862503105 472 2105100 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.3522226499085 0.0878063338107742 no 370 0.0881520500247833 544 2333 A French combination drug. SGTC_949 1165-0505 146 µM 1.3518341860165 0.0878678089531221 no 371 0.0882141826535487 550 6244267 SGTC_3024 9090631 49.47 µM 1.3492874083248 0.0882716366166806 no 372 0.0886223342416328 455 25236383 SGTC_2678 equilin 100 µM 1.34897645734295 0.0883210368983858 no 373 0.0886722640541264 513 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_393 acivicin 6.25 µM 1.34669217847707 0.0886845683714971 no 374 0.0890396961868719 470 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3241 9133421 49.47 µM 1.34189980485336 0.08945087005525 no 375 0.0898142425248075 428 17018221 SGTC_3077 9117319 49.47 µM 1.33280524018376 0.090918615816194 no 376 0.0912978628189089 453 17154678 SGTC_1093 fluphenazine 7.97 µM 1.33146633090912 0.0911361987728449 no 377 0.0915178081975054 555 6602611 An atypical antipsychotic. SGTC_1888 azatryptophan 97.5 µM 1.33135714260534 0.0911539597193026 no 378 0.091535762087606 465 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1108 betulinic acid 729.144 nM 1.32788515805503 0.0917200640240231 no 379 0.0921080242869214 531 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3032 9089427 49.47 µM 1.32735913321052 0.0918060586646113 no 380 0.0921949557162571 479 17173707 SGTC_2484 5809818 12.04 µM 1.32549609313247 0.0921111091580617 no 381 0.0925033321897667 521 2870548 SGTC_587 k089-0003 57 µM 1.32211476018748 0.0926666777921995 no 382 0.0930649697294224 371 9659696 SGTC_2208 7283366 200 µM 1.32153771290103 0.0927617363835589 no 383 0.0931610681992131 535 898663 SGTC_1692 fluoroquinolonic acid 71 µM 1.31699994446136 0.0935117698737502 no 384 0.0939193215896937 503 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1506 4226-2149 212 µM 1.31613810596869 0.093654725148316 no 385 0.0940638465719266 586 991114 SGTC_2348 9022543 33.42 µM 1.31532459687644 0.0937898118892951 no 386 0.0942004174995143 548 3162678 YDL140C RPO21 SGTC_2373 9071805 200 µM 1.31237226666902 0.0942812674381801 no 387 0.0946972797958933 538 10149009 SGTC_1860 st056228 74.6 µM 1.31037532413343 0.094614760891271 no 388 0.0950344485396615 522 688679 SGTC_2806 7952793 58.44 µM 1.30912598150665 0.0948238453541059 no 389 0.0952458398400939 537 2972490 SGTC_1029 k015-0030 64.7 µM 1.30887580327337 0.0948657549615453 no 390 0.0952882120786818 529 2208316 SGTC_2685 mycophenolic acid 18.85 µM 1.30840444333342 0.0949447537850656 no 391 0.0953680831713245 481 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_839 0122-0028 230 µM 1.30772551976084 0.0950586249484 no 392 0.0954832121489999 619 759448 SGTC_1020 4335-0961 93.3 µM 1.30760655603585 0.0950785882656752 no 393 0.0955033960407573 497 669075 SGTC_878 0828-0289 13.7 µM 1.30084954010679 0.0962175584293649 no 394 0.0966549804734435 601 745350 YLR208W SEC13 SGTC_2814 7977482 42.97 µM 1.30001259136341 0.0963593305824624 no 395 0.0967983268390515 625 6456762 SGTC_674 0498-0004 451 µM 1.2961230788615 0.0970201963776175 no 396 0.0974665424913402 540 4231473 SGTC_702 1488-0190 94 µM 1.29329591723207 0.0975026423467741 no 397 0.097954366098315 550 949357 SGTC_3009 9080819 71.4286 µM 1.28934224026856 0.0981802720199193 no 398 0.0986395660676617 548 17027216 SGTC_1563 conessine 56.1 µM 1.28563079820193 0.0988195179176981 no 399 0.0992859714623493 647 441082 An anti-amoebic, histamine inhibitor. SGTC_2880 9042983 58.44 µM 1.27905719002928 0.0999591981643488 no 400 0.100438458718569 571 6464714 SGTC_246 cycloheximide 667 µM 1.27800512584097 0.100142484213838 no 401 0.100623809462287 490 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_896 0964-0007 44.5 µM 1.27492275604964 0.100680893517573 no 402 0.101168291858993 573 6756758 SGTC_391 gliotoxin 8.33 µM 1.27461966116292 0.100733950053528 no 403 0.101221947497739 596 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3246 9135460 32.98 µM 1.27431570777619 0.10078717734397 no 404 0.101275775934204 473 41446951 SGTC_29 0299-0004 12.984 µM 1.27254788920216 0.101097158331549 no 405 0.101589260114266 461 16871 A napthoquinone isolated from Swertia calycina. SGTC_1342 1486-1464 234 µM 1.27162532401747 0.101259202668956 no 406 0.101753137312434 603 3253938 SGTC_2329 6138490 200 µM 1.26996730369985 0.101550901856946 no 407 0.102048138532305 508 720019 SGTC_2877 9040724 71.43 µM 1.2699479994438 0.101554301697683 no 408 0.102051576879332 552 6463895 SGTC_2790 5423970 71.43 µM 1.26747484880891 0.101990555647873 no 409 0.102492775632237 608 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1376 2910-0861 41.3 µM 1.26588451437003 0.102271803805615 no 410 0.102777215660574 609 1112859 SGTC_3075 9116269 49.47 µM 1.25845219465364 0.103593677581657 no 411 0.104114132870228 576 17015205 YNL244C SUI1 SGTC_595 3909-8003 73.7 µM 1.25813157959214 0.103650978169388 no 412 0.10417208709384 573 699517 SGTC_1618 st003135 44.5 µM 1.25637775825839 0.103964829556624 no 413 0.104489520863007 559 1270615 SGTC_1622 st003707 19.4 µM 1.25527335408573 0.10416281916701 no 414 0.10468977231576 615 10140899 SGTC_1583 clindamycin 39.6 µM 1.25203072386121 0.104745713626455 no 415 0.105279334426982 539 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2228 7354201 200 µM 1.25053836684645 0.105014771698165 no 416 0.105551474538826 558 753451 SGTC_658 3253-0951 102 µM 1.24848272988081 0.105386202523191 no 417 0.105927164524923 701 1184878 SGTC_1984 st072354 53.1 µM 1.24681816300297 0.105687666921627 no 418 0.106232089556396 577 5762938 SGTC_1300 1094-0077 113 µM 1.24446021789863 0.10611577323843 no 419 0.106665116043996 539 5532636 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.23631746937286 0.107603793730425 no 420 0.108170290023786 555 6708514 SGTC_1133 3473-0247 50 µM 1.23505095908799 0.107836582635743 no 421 0.108405769639791 629 711311 SGTC_1466 k213-0079 57.5 µM 1.23042295876658 0.108690308929717 no 422 0.109269380162569 603 3657981 SGTC_467 ro 31-8220 72.8 µM 1.22550419677545 0.109602988829594 no 423 0.110192654906836 629 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1170 0310-0127 64.8 µM 1.22474702900155 0.109743969163978 no 424 0.110335274365359 616 774975 SGTC_2670 beta-carotene 100 µM 1.22350522618751 0.10997546752008 no 425 0.110569465733974 516 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2905 7799065 20.05 µM 1.2219060054755 0.110274112056193 no 426 0.110871587079374 570 1296806 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.22166694225732 0.110318805550235 no 427 0.110916801153022 642 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1716 st033144 30.6155 µM 1.21734338385537 0.111129348898809 no 428 0.111736797160432 632 674617 SGTC_1236 0330-0013 258 µM 1.21729946802009 0.111137603679841 no 429 0.111745148322571 584 4617066 SGTC_381 3461-2219 42.7 µM 1.21687870183209 0.111216716605271 no 430 0.111825185068753 661 2883159 SGTC_283 0987-0079 11.7 µM 1.21465483290675 0.111635520650484 no 431 0.11224888303862 641 411556 SGTC_3278 9139605 49.47 µM 1.21378413060659 0.111799800260632 no 432 0.112415083911503 600 7958859 SGTC_473 2-arachidonoylglycerol 10 µM 1.21232507864144 0.112075474147454 no 433 0.112693983811638 590 5282280 An endocannabinoid. SGTC_2650 prasterone 100 µM 1.21124106941188 0.11228060169915 no 434 0.112901513431706 509 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_307 1501-1223 22.3 µM 1.21118601922714 0.112291026024078 no 435 0.112912059863256 608 2830329 SGTC_31 0508-1974 57.237 µM 1.20706981032322 0.113072433146332 no 436 0.113702630085642 605 6810525 SGTC_1431 4049-0260 9.09 µM 1.20696281833554 0.113092795754968 no 437 0.113723231736794 623 3854841 SGTC_762 1165-0429 115 µM 1.20694316870096 0.113096535738272 no 438 0.113727015626277 619 5967793 SGTC_3008 9078912 71.4286 µM 1.20664172982398 0.113153920710696 no 439 0.113785074335501 585 16648731 SGTC_2625 euphol 100 µM 1.20357776337666 0.113738387595405 no 440 0.114376409205725 667 6708538 A triterpene alcohol. SGTC_3272 9137413 49.47 µM 1.19967721054108 0.114485546529611 no 441 0.115132363573506 583 17614870 SGTC_175 3793-3120 23.7 µM 1.19323551457107 0.11572710399496 no 442 0.116388574707126 573 5322297 SGTC_3332 9141069 11.198 µM 1.1930325682506 0.115766374183308 no 443 0.116428309156745 559 17332883 SGTC_2456 5770359 74.46 µM 1.18932332174879 0.116485782495607 no 444 0.117156230716169 649 3118787 SGTC_2605 digitonin 300 nM 1.18318437204154 0.11768338812216 no 445 0.118368042621092 729 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_548 1436-0017 110 µM 1.17980542481522 0.118346269907221 no 446 0.119038805725524 719 9677137 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.17874562257108 0.11855472464212 no 447 0.119249741502422 618 5355888 SGTC_604 1000-0114 314 µM 1.17868776035997 0.118566113147512 no 448 0.119261265590512 689 1572745 SGTC_1430 4049-0248 69.1 µM 1.17503938231669 0.119285752725104 no 449 0.119989480145862 704 22774488 SGTC_614 0462-0418 107 µM 1.17441370964866 0.119409475148196 no 450 0.120114678283555 568 5188303 SGTC_2088 5278280 127.392 µM 1.17391031570705 0.119509083512404 no 451 0.120215475052646 668 791502 SGTC_1798 st045719 60.953 µM 1.16710710797799 0.12086101040395 no 452 0.121583558865559 593 3980186 SGTC_3234 9132280 49.47 µM 1.16603764997838 0.121074507162355 no 453 0.121799611743497 654 17612295 SGTC_2511 berberine 10.47 µM 1.16555295366903 0.121171354794053 no 454 0.121897619307163 646 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_203 k066-0004 30.888 µM 1.16363815457879 0.121554485399408 no 455 0.122285341118463 767 6795412 SGTC_2883 9059145 45.46 µM 1.16202619680856 0.121877680219434 no 456 0.122612411995287 614 16476510 SGTC_3187 9109394 49.47 µM 1.16140047130669 0.12200329962683 no 457 0.122739538706704 657 17098090 SGTC_703 3875-0075 71.8 µM 1.15996675225368 0.122291473012137 no 458 0.123031171471737 699 2850814 SGTC_621 3584-0052 32.1 µM 1.15830612951051 0.122625850182393 no 459 0.123369565445475 684 2273927 SGTC_3130 9127414 49.47 µM 1.15814886585178 0.122657549455394 no 460 0.123401645669001 647 1494646 SGTC_325 2810-4341 181 µM 1.15614222827391 0.123062527428223 no 461 0.123811492853127 644 774970 SGTC_2935 9038016 29.96 µM 1.15612790685899 0.123065421129196 no 462 0.123814421361729 692 6463195 SGTC_1321 1326-2144 215 µM 1.15486109371445 0.123321574680286 no 463 0.12407365699003 628 3513030 SGTC_626 0214-0009 33 µM 1.14991657236046 0.12432494582451 no 464 0.125089117238128 684 3437874 SGTC_3340 9146634 11.102 µM 1.14825829625842 0.124662727885569 no 465 0.125430974875929 670 4907387 SGTC_366 0181-0206 4.31 µM 1.14197854903439 0.125947690855183 no 466 0.126731468113562 707 274874 SGTC_3304 9125678 46.087 µM 1.14008979132477 0.12633596915469 no 467 0.127124447287666 680 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1872 amphotericin b 148 nM 1.13883130932139 0.126595142132285 no 468 0.127386760125245 680 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1216 1165-0504 9.65 µM 1.13807456837691 0.126751164250062 no 469 0.127544673229454 695 6304004 SGTC_45 0kpi-0036 14.9 µM 1.13747605982502 0.126874657372074 no 470 0.127669663506702 624 2795021 SGTC_758 0868-0029 16 µM 1.13329258005827 0.127740193638032 no 471 0.12854570333843 676 762687 SGTC_179 1273-0063 6.77 µM 1.13282321648501 0.127837557524294 no 472 0.128644249890523 612 3108139 SGTC_1406 3909-7906 11.9 µM 1.12832655342041 0.12877295077156 no 473 0.129591016656321 699 X1406 SGTC_844 0330-0132 15.3 µM 1.12755688109163 0.12893353227796 no 474 0.12975355274999 706 2828079 SGTC_2423 st077119 87.2 µM 1.12723234969002 0.129001282882579 no 475 0.129822128190409 682 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2746 daunorubicin 9.88 µM 1.12695996524378 0.129058166112115 no 476 0.129879704032249 536 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1550 gossypolone 36.6 µM 1.12485869449259 0.129497568234154 no 477 0.130324458853484 695 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2322 7413319 38.22 µM 1.12401251973294 0.12967480641364 no 478 0.130503857367655 789 1840400 SGTC_3349 9149703 23.001 µM 1.12138976192653 0.13022523149364 no 479 0.131060996087249 652 4910494 SGTC_2198 6589944 200 µM 1.12047576811121 0.130417426096871 no 480 0.131255536544663 587 5290268 SGTC_2193 5925765 200 µM 1.12044330437575 0.130424256176712 no 481 0.131262450005208 619 877370 SGTC_1914 st062367 72.6 µM 1.12033264673745 0.130447539413892 no 482 0.131286017488948 650 978205 SGTC_2549 cedrol 20.94 µM 1.11966463367349 0.130588155673097 no 483 0.131428350679963 620 6708665 A sedative which affects the nervous system. SGTC_924 2046-0044 21.3 µM 1.11760064188314 0.131023286476068 no 484 0.131868797261974 694 3623589 SGTC_2995 9067767 71.4286 µM 1.11682310010696 0.131187467327073 no 485 0.132034984927452 615 11673567 SGTC_1243 0416-0003 5.65 µM 1.11586525487443 0.131389915195644 no 486 0.132239908179161 649 2141977 SGTC_374 0880-0231 82.3 µM 1.11572269408665 0.131420064932783 no 487 0.132270426642626 689 6833587 SGTC_1284 0929-0043 16 µM 1.11549414470334 0.131468410096464 no 488 0.132319363101608 707 1239883 SGTC_3296 9122258 64.045 µM 1.11180605940535 0.132250250417962 no 489 0.133110773003677 685 4730474 SGTC_777 1315-0167 517 µM 1.10753311307215 0.133160076613914 no 490 0.134031751993414 652 4221767 SGTC_1077 5-fluorocytosine 377 nM 1.10391145723488 0.133934590777432 no 491 0.134815774177806 676 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3275 9138069 49.47 µM 1.09968363780842 0.134842646352055 no 492 0.135734993130848 673 17617007 SGTC_2100 5377183 190 µM 1.09935092940052 0.134914284665025 no 493 0.135807512870344 757 2844202 SGTC_2781 5567276 71.43 µM 1.09921282788279 0.134944028158456 no 494 0.135837622353978 678 2853274 SGTC_2723 salbutamol 83.58 µM 1.09233093306589 0.136431909032686 no 495 0.137343834338304 602 9884233 β2-adrenoceptor agonist SGTC_1749 st037932 54.2 µM 1.0912115523507 0.136674978675187 no 496 0.137589902882515 667 594497 SGTC_776 4476-4378 112 µM 1.08959642058098 0.137026220502968 no 497 0.13794548026008 677 2892008 SGTC_358 0075-0058 9.45 µM 1.08675057502429 0.137646604687275 no 498 0.138573528047786 790 1069125 SGTC_160 3453-0671 289.699 µM 1.08578001823073 0.13785862030711 no 499 0.13878816440778 765 5322268 SGTC_2086 5274770 176.623 µM 1.08546979946545 0.137926433755445 no 500 0.138856816285864 710 689278 SGTC_1003 4049-0218 100 µM 1.0829998577185 0.13846717185364 no 501 0.139404243097167 745 295161 SGTC_2420 aureobasidin a 50 nM 1.08241657826449 0.13859507832727 no 502 0.139533732537503 768 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1751 st044839 27.194 µM 1.08222644072935 0.138636790692754 no 503 0.139575961201054 715 5291326 SGTC_1425 4048-4433 7.33 µM 1.08111610058851 0.138880547861511 no 504 0.139822736150933 772 23734946 SGTC_1329 1447-1697 50.6 µM 1.07946031354548 0.139244590862446 no 505 0.140191288186275 719 2840515 SGTC_1847 st056231 15 µM 1.07901232669047 0.1393431972113 no 506 0.140291116299703 771 5393180 SGTC_3223 9129970 49.47 µM 1.07804740379905 0.139555747641119 no 507 0.140506300914015 759 17248386 SGTC_3087 9117406 49.47 µM 1.07589880246922 0.140029827125831 no 508 0.140986258784521 714 42546093 SGTC_2610 ononetin 44.17 µM 1.0719829899791 0.140896645704556 no 509 0.141863836187497 732 259632 SGTC_3249 9135183 49.47 µM 1.06971252945193 0.141400906868546 no 510 0.142374362409372 754 4902779 SGTC_132 0417-1715 25.805 µM 1.06723398036627 0.141952778576583 no 511 0.142933095887791 769 6769098 SGTC_2233 sulbentine 40.3845 µM 1.06630801397528 0.142159327159899 no 512 0.143142214001707 801 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1285 0929-0069 65.5 µM 1.06592973514354 0.14224376555531 no 513 0.143227703053117 731 1206237 SGTC_2817 7995342 71.43 µM 1.06336239768588 0.14281773648909 no 514 0.143808819122597 645 18879975 SGTC_1978 st071761 42 µM 1.05910461631731 0.143773081015483 no 515 0.144776068917984 708 5147680 SGTC_2649 anisomycin 9.56 µM 1.05882208797201 0.143836625827777 no 516 0.144840406160282 728 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1711 st032263 62.8 µM 1.05709991802407 0.144224377094002 no 517 0.145232994315744 720 3958979 SGTC_2075 5212009 200 µM 1.05653558171994 0.144351592103931 no 518 0.145361796780249 666 780898 SGTC_1781 st038725 66.3 µM 1.05461737141749 0.144784568248359 no 519 0.145800177839984 807 4270275 YIL048W NEO1 SGTC_2036 5160441 105 µM 1.05438072616086 0.144838044073493 no 520 0.145854321428136 816 134534 YIL048W NEO1 SGTC_1217 1183-1422 255 µM 1.05407134485754 0.144907976457447 no 521 0.145925127142425 799 2849664 SGTC_948 3448-0295 75.3 µM 1.05072514877496 0.145665801391114 no 522 0.146692421084423 793 678569 SGTC_1363 1636-0063 10.4 µM 1.05019735473764 0.145785575623352 no 523 0.146813692746971 795 6072185 SGTC_2236 dapsone 200 µM 1.04893395279992 0.146072552866625 no 524 0.147104258749874 788 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1474 0330-0125 5.35 µM 1.04513795033873 0.146937083115644 no 525 0.14797960821099 763 X1474 SGTC_407 eburnamonine 100 µM 1.04199219957304 0.147656115322819 no 526 0.148707647728157 694 3195 SGTC_2659 sanguinarine 24.21 µM 1.0396871171334 0.148184487499837 no 527 0.149242643909079 738 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1399 3562-5772 25 µM 1.03881280700806 0.148385227830245 no 528 0.149445901963281 674 23847490 SGTC_1985 st071382 65.5 µM 1.03801550208457 0.148568446365222 no 529 0.149631418993583 778 6123237 SGTC_1388 3346-4487 254 µM 1.03619118782354 0.148988237672735 no 530 0.150056478532737 809 3345614 SGTC_2089 5281248 129.67 µM 1.03214263038903 0.149922675713969 no 531 0.151002652853936 776 2737878 SGTC_1196 1588-0294 184 µM 1.02459205562151 0.151675826881343 no 532 0.152777857297748 726 6144269 SGTC_3041 9091929 49.47 µM 1.02025529693248 0.15268890531149 no 533 0.153803699195037 800 25236887 SGTC_827 3253-0474 693 µM 1.01994630287075 0.152761258052739 no 534 0.15387696402652 822 5402065 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.01729052944994 0.153384060219915 no 535 0.154507620272487 805 688669 SGTC_3098 9119039 49.47 µM 1.01627805401552 0.153621936836542 no 536 0.15474849809795 785 17161528 SGTC_3059 1327-0034 3 µM 1.01542032275328 0.153823648019784 no 537 0.154952754794094 769 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1111 tnp00062 510.699 nM 1.01412382194912 0.154128876487107 no 538 0.155261836145282 815 676306 SGTC_1652 st011932 78 µM 1.01276028982354 0.154450317745336 no 539 0.155587336265732 779 1551076 SGTC_559 1550-0661 158 µM 1.01201475495093 0.154626258603403 no 540 0.155765499313589 792 5830875 SGTC_981 1488-1094 54.9 µM 1.01193517908374 0.154645045754701 no 541 0.155784523776465 728 3449522 SGTC_1619 st003326 88.7 µM 1.01151325646213 0.154744683117392 no 542 0.155885419793951 753 2849032 SGTC_1991 st073000 8.92 µM 1.01026025180708 0.155040831126887 no 543 0.156185309608812 836 4301969 YIL048W NEO1 SGTC_1961 st076550 68.7 µM 1.00869573214881 0.155411130835008 no 544 0.156560289607919 718 1579337 SGTC_656 4090-1979 187 µM 1.00708786630149 0.155792297543418 no 545 0.156946275780697 845 22330961 SGTC_2264 7948757 110.76 µM 1.00705285993099 0.15580060313542 no 546 0.156954686408896 756 2971411 SGTC_600 1495-0418 41.6 µM 1.00512803711913 0.156257734884309 no 547 0.157417600584053 769 5377768 SGTC_454 lyso-paf C-16 6.67 µM 1.0003839716107 0.157388185587007 no 548 0.15856236188 815 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2462 5162487 171.77 µM 0.999838497384283 0.157518508909151 no 549 0.158694335992066 826 2259986 SGTC_1986 st071812 45 µM 0.999708125024589 0.157549667640425 no 550 0.15872588943759 762 11838594 SGTC_1115 galangin 695.678 nM 0.997978157139228 0.157963509888155 no 551 0.159144975282843 866 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_469 w7 172 µM 0.995251043392993 0.158617337053059 no 552 0.159807090925231 781 45115570 A P450 inhibitor. SGTC_1490 4089-0339 670 nM 0.994082628149332 0.158898007565434 no 553 0.16009132099816 783 742542 SGTC_2946 9065502 71.43 µM 0.993489280079515 0.15904066302779 no 554 0.160235786017332 648 16489101 SGTC_1277 0873-0036 22 µM 0.992907444229784 0.159180632129387 no 555 0.160377530828458 829 5965735 SGTC_298 1391-0729 10 µM 0.992354867351226 0.159313637238018 no 556 0.160512223507428 791 3237558 SGTC_1775 st081588 35.1725 µM 0.990354681448201 0.159795689752636 no 557 0.161000394005583 839 1426443 YGL099W LSG1 SGTC_35 0133-0054 64.071 µM 0.990334006483796 0.159800677476292 no 558 0.161005445044894 742 99677 SGTC_1303 1160-0052 261 µM 0.989804269605402 0.159928508376903 no 559 0.161134898765175 819 3562476 SGTC_1879 gemcitabine 100 µM 0.989497931225148 0.160002461458323 no 560 0.161209790768883 818 60750 A nucleoside analog which inhibits DNA replication. SGTC_1393 3470-5649 58.2 µM 0.987095721995566 0.160583153383749 no 561 0.161797857398825 699 4108395 SGTC_183 3914-0051 30.55 µM 0.98433083757447 0.161253217570324 no 562 0.162476435943752 836 1596232 SGTC_57 miconazole 162.5 nM 0.981671490139852 0.161899423393635 no 563 0.163130857587637 784 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2232 chlorophetanol 41.5365 µM 0.980506918519539 0.16218293791127 no 564 0.163417978102991 950 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2750 bromebric acid 70.15 µM 0.976947726851386 0.16305142428541 no 565 0.164297515951215 872 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1118 chelidonine 707.474 nM 0.974513685628932 0.163647097532438 no 566 0.164900773645357 888 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2079 5212404 121 µM 0.973979911089902 0.163777914709076 no 567 0.165033256944382 852 758462 SGTC_2290 7904846 200 µM 0.972940325750562 0.164032890498812 no 568 0.165291480670282 805 2962154 SGTC_1815 st051655 58.2 µM 0.972845609418936 0.164056134065649 no 569 0.165315020351166 829 5984156 SGTC_1126 isoteolin 1.0172 µM 0.97136165949581 0.164420577132035 no 570 0.165684106987139 796 133323 SGTC_2911 7942208 15.64 µM 0.971023411642371 0.164503720767454 no 571 0.165768310186434 772 1243384 SGTC_1414 3917-0015 5.4 µM 0.969024166332256 0.16499570534477 no 572 0.166266565899229 844 6618702 SGTC_408 cantharidin 100 µM 0.967936768043123 0.165263697515229 no 573 0.166537975056428 849 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3143 9086658 49.47 µM 0.967538041198652 0.165362035339008 no 574 0.166637566893721 890 25236626 SGTC_2833 9001315 45.46 µM 0.966193851265113 0.165693831197782 no 575 0.166973594532077 818 2989378 SGTC_125 0133-0007 11.75 µM 0.965932676165121 0.1657583487959 no 576 0.167038935120745 948 26541 SGTC_1920 st075728 45.7 µM 0.965881778813223 0.165770923764573 no 577 0.167051670501131 830 3400306 SGTC_2692 st077426 47.7 µM 0.964359015899412 0.16614743084937 no 578 0.167432981167339 861 25238571 SGTC_3092 9117248 49.47 µM 0.962431648459167 0.166624768910459 no 579 0.167916411155769 906 17141857 SGTC_2819 7996655 46.38 µM 0.961045826693314 0.166968532448452 no 580 0.168264563215131 736 6456960 SGTC_684 1140-0066 328 µM 0.960500996464345 0.167103806867789 no 581 0.16840156485989 861 6813534 SGTC_1039 k821-0043 94 µM 0.960241239928759 0.167168325982542 no 582 0.168466907833503 868 15992768 SGTC_920 mycophenolic acid 780.421 nM 0.958906745558566 0.167500044883319 no 583 0.168802863124068 812 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2092 5303694 80.6725 µM 0.958587010216587 0.167579585299888 no 584 0.168883419501156 850 1963699 SGTC_2468 5987765 72.9 µM 0.958324073870868 0.167645014083739 no 585 0.16894968404198 888 26772094 SGTC_2476 5806916 10.51 µM 0.95699453709196 0.167976106409065 no 586 0.169285006175375 830 2870194 SGTC_2849 9019321 12.99 µM 0.956601568754128 0.1680740471849 no 587 0.169384198362516 775 16489627 SGTC_2980 9014342 25.29 µM 0.956286810117031 0.168152522002592 no 588 0.16946367593195 788 2996599 SGTC_2617 dihydrotanshinone i 20.83 µM 0.954885169055403 0.168502261737631 no 589 0.169817885303709 878 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1857 st056007 79.3 µM 0.950733497522541 0.169540935584392 no 590 0.170869839548644 842 619834 SGTC_1157 4092-0394 27.6 µM 0.950276205163798 0.169655592568283 no 591 0.170985963091705 918 3659885 SGTC_2653 dihydrofissinolide 100 µM 0.949935795083168 0.169740975926302 no 592 0.171072438646539 854 6857746 SGTC_2364 9055074 200 µM 0.949116486012909 0.169946592088735 no 593 0.17128068523648 798 6470630 SGTC_1191 1487-1166 10.6 µM 0.948404931961877 0.170125295240398 no 594 0.171461674806534 940 3955771 SGTC_1248 0469-0687 58.6 µM 0.947223433634175 0.170422288364888 no 595 0.171762468395795 869 4017482 SGTC_1873 rapamycin 2 nM 0.945990049498893 0.17073267804704 no 596 0.17207683074486 884 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1297 1068-0111 14.1 µM 0.944357065813639 0.171144186017002 no 597 0.172493606796104 832 767057 SGTC_452 diindolylmethane 8 µM 0.94340466838069 0.171384480482831 no 598 0.172736978114502 795 3071 Inhibits expression of several cancer promoting factors. SGTC_223 busulfan 5 mM 0.94185472657828 0.171775999092095 no 599 0.173133510907858 779 2478 A DNA alkylator. SGTC_1308 1187-1617 41.4 µM 0.941501538814806 0.17186529492949 no 600 0.17322395052705 884 2882570 SGTC_1168 k815-0004 80.5 µM 0.940286285781974 0.172172771620935 no 601 0.17353536613319 866 642433 SGTC_293 4049-0273 38.5 µM 0.939659895826148 0.172331394411538 no 602 0.173696021239274 819 1380311 SGTC_379 3970-0972 5.9 µM 0.938651843876395 0.172586862405048 no 603 0.173954762759669 848 2898042 YBL034C STU1 SGTC_2794 7785382 27.27 µM 0.936457440830981 0.173143818788854 no 604 0.174518857612566 937 2205081 SGTC_60 0986-0278 202 µM 0.936070378899928 0.173242176722234 no 605 0.174618476434338 750 3110598 SGTC_2430 5571206 200 µM 0.935619700162387 0.173356745411886 no 606 0.174734513915084 968 1731771 SGTC_474 dl-dihydrosphingosine 5 µM 0.933710131493091 0.173842718855575 no 607 0.175226718701821 873 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1299 1079-1439 3.74 µM 0.93292335880146 0.174043199440439 no 608 0.175429770430538 836 323161 SGTC_1512 0259-0544 12.2 µM 0.932276690678906 0.174208089444987 no 609 0.175596775351065 912 18476 SGTC_2737 bleomycin 30.5 nM 0.931956595103369 0.174289745406841 no 610 0.175679478722894 920 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1104 tacrolimus 29.8 µM 0.931730625121437 0.174347404694902 no 611 0.175737877641743 896 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1495 4469-0029 237 µM 0.928170920978828 0.175257309950479 no 612 0.176659457919447 957 793680 SGTC_3277 9138724 49.47 µM 0.928041781932496 0.175290376024648 no 613 0.176692948374328 775 15943418 SGTC_909 3448-9333 149 µM 0.927908593611206 0.175324483059971 no 614 0.1767274931583 819 3344074 SGTC_3311 9131146 2.8755 µM 0.916887868191328 0.178161255037659 no 615 0.179600700920416 893 4900406 YPR165W RHO1 SGTC_2558 carylophyllene oxide 100 µM 0.915408641930173 0.178544203199593 no 616 0.179988571634532 939 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3327 9140648 26.9345 µM 0.911680539560084 0.179511647348035 no 617 0.180968455584807 897 8029710 SGTC_326 k292-0812 17.5 µM 0.906069834030586 0.180973825596742 no 618 0.182449445403299 902 3579357 SGTC_3217 9129673 49.47 µM 0.902968248888352 0.181785308296177 no 619 0.183271373273218 856 17248312 SGTC_1070 indatraline 8.81 µM 0.900940171957632 0.182317152691079 no 620 0.18381006530298 896 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1963 st076565 50.3 µM 0.900687911425171 0.182383373603127 no 621 0.183877138928865 895 4914280 SGTC_42 0133-0086 60.653 µM 0.898835986391772 0.182869982445082 no 622 0.184370014422083 849 162923 Model of phenazepam hydroxylation. SGTC_1667 st014849 34.6 µM 0.897884058493308 0.183120424499007 no 623 0.184623682184686 924 5348460 SGTC_1906 st060206 94.7 µM 0.897817006257757 0.183138073287754 no 624 0.184641558302617 960 5133468 SGTC_3135 9127742 49.47 µM 0.896530164839187 0.183476987792339 no 625 0.18498483856813 860 3643468 SGTC_272 doxorubicin 8.13 µM 0.895810152745083 0.183666787318169 no 626 0.185177083259535 974 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1358 1509-0022 2.48 µM 0.894607402797026 0.183984112197905 no 627 0.185498496585381 938 3258434 SGTC_1436 4092-1007 8.32 µM 0.892992441639524 0.184410728464558 no 628 0.185930610169007 915 2881121 SGTC_98 0074-0023 107.663 µM 0.892386226801576 0.184571027956657 no 629 0.18609297547653 954 3563821 SGTC_3347 9188721 44.724 µM 0.891170750681076 0.184892693456683 no 630 0.186418786706812 867 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1473 k844-0725 134 µM 0.890629889736302 0.185035939676541 no 631 0.186563879281689 1023 54682906 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.890471869029219 0.185077804238168 no 632 0.186606283468976 900 5377381 SGTC_2366 9070441 60.58 µM 0.88993702952051 0.185219543384059 no 633 0.186749849661636 962 6837235 SGTC_706 4262-0057 46.9 µM 0.88965539257922 0.185294207776751 no 634 0.186825476529626 917 883298 SGTC_106 0092-0003 11.579 µM 0.887850463936859 0.185773153549878 no 635 0.187310596824668 866 1072148 SGTC_2021 4019055 173 µM 0.886496904149751 0.18613282999421 no 636 0.18767491083373 993 44827708 YER133W GLC7 SGTC_438 sphingosine 6.67 µM 0.886154085026102 0.186223994511351 no 637 0.18776725088722 859 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1856 st057054 55.7 µM 0.885490336794791 0.18640058105348 no 638 0.187946114553729 962 1266018 SGTC_122 0236-0016 402.397 µM 0.884979949444375 0.186536437303899 no 639 0.188083722790394 999 6808838 SGTC_3080 9117754 49.47 µM 0.882103188176138 0.187303327523885 no 640 0.188860504149725 987 9550191 SGTC_2492 derrusnin 100 µM 0.879320693810818 0.188046939590964 no 641 0.189613709342485 859 1715307 Part of coumarin class of compounds. SGTC_144 4161-2749 112.381 µM 0.879212022146711 0.188076018647598 no 642 0.18964316358279 839 797501 YMR168C CEP3 SGTC_269 exalamide 29 µM 0.877755261079239 0.188466095996068 no 643 0.190038274091906 920 3316 A derivative of salicylamide. SGTC_861 0443-0273 110 µM 0.876911329753926 0.188692303820796 no 644 0.190267400929805 957 6149169 SGTC_1367 1812-0510 76.9 µM 0.874562254664166 0.189322831971346 no 645 0.190906066465756 923 1142582 YDR527W RBA50 SGTC_1697 st025554 27.742 µM 0.874341931934902 0.189382036459726 no 646 0.190966035099657 912 1269519 SGTC_1006 4099-6547 255 µM 0.874041116079282 0.189462889227296 no 647 0.191047931444289 936 3146833 SGTC_62 0180-0423 3.232 µM 0.872961900076847 0.189753133814957 no 648 0.191341922441701 923 30102 YGL099W LSG1 SGTC_2281 7943571 200 µM 0.872500816390423 0.189877221089138 no 649 0.191467611493225 1031 1244024 SGTC_1822 st052468 42 µM 0.868823643983111 0.190868609752617 no 650 0.192471799297877 947 2873678 SGTC_3276 9139060 49.47 µM 0.867828277181954 0.191137512049234 no 651 0.192744173750422 938 4870619 SGTC_2359 9039622 200 µM 0.866919412903916 0.191383248119489 no 652 0.19299308304186 989 6463596 SGTC_1931 st074438 57.1 µM 0.865795469982707 0.191687404143651 no 653 0.193301166924712 961 2787313 SGTC_2011 4012611 177 µM 0.86520953275816 0.191846084979993 no 654 0.193461897068273 952 2049887 SGTC_1776 st049249 45.9 µM 0.865183587063656 0.191853113333001 no 655 0.193469016191702 983 1822314 SGTC_2600 tangeritin 87.95 µM 0.864620289348993 0.192005742255898 no 656 0.193623616336221 900 68077 A bioactive flavone. SGTC_3177 9107506 49.47 µM 0.864206971513673 0.192117780475804 no 657 0.193737101586705 928 8897194 SGTC_347 4534-1311 26.2 µM 0.863467566447243 0.19231831104292 no 658 0.1939402221978 958 2862016 SGTC_1439 4092-1168 46 µM 0.861223412866811 0.192927720796582 no 659 0.194557503751061 971 2886240 SGTC_782 0083-0095 30.5 µM 0.860210162154864 0.193203259518091 no 660 0.194836601961801 1009 3591729 An indicator and reagent. SGTC_63 0099-0242 26.702 µM 0.859941405500034 0.193276384248124 no 661 0.194910671372082 1008 3898502 YLR359W ADE13 SGTC_2271 7849410 118.62 µM 0.856982768617466 0.194082501811985 no 662 0.195727203877259 974 972430 SGTC_1824 st053723 68.6 µM 0.856321526546373 0.194262945123148 no 663 0.195909978715522 1000 675225 SGTC_753 1322-0200 289 µM 0.855495059081686 0.194488619621014 no 664 0.196138569287404 983 5403907 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.854046969068322 0.19488441837889 no 665 0.196539482683821 989 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_814 3342-0569 96 µM 0.853575795624051 0.195013307262562 no 666 0.196670037188385 966 4346283 SGTC_3281 9140613 49.47 µM 0.852657368609459 0.195264690695278 no 667 0.196924669336145 905 16013766 SGTC_2765 myclobutanil 7.74 µM 0.850083865882609 0.1959701344438 no 668 0.197639230505834 955 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1204 4049-0315 18.3 µM 0.849769770403463 0.196056339453842 no 669 0.197726549732992 927 588402 SGTC_2048 5246248 200 µM 0.849711057661023 0.196072455998707 no 670 0.197742874589114 978 677046 SGTC_2894 9048625 32.47 µM 0.848722774037283 0.196343858706845 no 671 0.198017785337999 989 4092861 SGTC_334 1502-1024 68.5 µM 0.848007414487069 0.19654045293608 no 672 0.198216920754448 996 3296216 SGTC_1624 st003710 6.25 µM 0.846952042954461 0.196830706521453 no 673 0.198510926307751 1029 24207033 SGTC_1119 parthenolide 318.541 nM 0.846264605378845 0.197019908579936 no 674 0.198702574174398 1024 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_205 1486-1330 71.903 µM 0.845789129634859 0.197150837187138 no 675 0.198835195329124 951 4118834 SGTC_2239 6685329 187.64 µM 0.841237492959649 0.198406853629543 no 676 0.200107450106729 954 805680 SGTC_829 1635-0120 117 µM 0.839804246465217 0.198803352948838 no 677 0.200509076064173 1031 285054 SGTC_1750 st081859 2.357 µM 0.839064925992599 0.199008068287443 no 678 0.200716438411232 1076 5291695 SGTC_1151 3909-8316 15.3 µM 0.838878004274966 0.199059846389766 no 679 0.200768886023699 974 800431 SGTC_1634 st006576 41 µM 0.837665070580033 0.199396031306841 no 680 0.201109418026466 979 3915356 SGTC_271 rotenone 740 µM 0.836056056599145 0.199842523631063 no 681 0.201561684011471 1044 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2043 5101342 149 µM 0.834222236614829 0.200352130906767 no 682 0.202077881396067 953 678451 SGTC_530 4358-1714 28 µM 0.832376374091666 0.200865872338673 no 683 0.202598266695018 1016 1564641 SGTC_2735 sertaconazole 140 nM 0.831915665911829 0.200994220046792 no 684 0.202728274279613 976 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2710 st078562 53.7235 µM 0.830918874432922 0.201272082377001 no 685 0.203009730162847 1019 17250908 SGTC_594 1487-1584 10.8 µM 0.830895506138896 0.201278599207651 no 686 0.203016331275607 1021 5013332 SGTC_2014 4013930 200 µM 0.828881182870631 0.201840818698071 no 687 0.203585822089683 1040 64556 SGTC_1698 5-fluorocytosine 1.055 µM 0.828838888422122 0.201852633607589 no 688 0.203597789807274 1023 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1990 st072050 59.8 µM 0.828648526000363 0.201905816274881 no 689 0.203651660313745 1017 17233948 SGTC_1746 st038117 42 µM 0.828156867945812 0.202043212477142 no 690 0.203790833543335 965 2898218 SGTC_1811 st050069 61.5 µM 0.827979396255233 0.202092821533764 no 691 0.203841084227254 1019 3877702 SGTC_296 1222-0039 74.9 µM 0.826462034262116 0.202517270608502 no 692 0.204271023062885 973 5984176 SGTC_2114 5491910 81.25 µM 0.826430482712225 0.202526102121913 no 693 0.204279968803145 993 2849228 SGTC_779 1360-0071 233 µM 0.826063475792694 0.202628847001457 no 694 0.204384042589508 1066 7566 SGTC_2326 6164455 177.58 µM 0.826015216600743 0.202642359649378 no 695 0.204397730011145 957 2888790 SGTC_2601 securinine 100 µM 0.825610765750068 0.202755627678065 no 696 0.204512463062702 962 442872 A GABA receptor antagonist. SGTC_1353 1498-1206 8.11 µM 0.825067513287942 0.202907827151981 no 697 0.204666631116616 1032 6756808 SGTC_3175 9106517 49.47 µM 0.824691906295041 0.20301309838659 no 698 0.204773263959856 976 41468073 SGTC_1385 3091-4834 14.1 µM 0.823074674446477 0.203466731754449 no 699 0.205232764825158 962 4072814 SGTC_2543 pimpinellin 60.67 µM 0.822980769681676 0.203493090592821 no 700 0.20525946460392 947 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1041 0206-0046 107 µM 0.822840182819123 0.203532556789392 no 701 0.205299441279644 989 50494 SGTC_419 nsc-638432 893 µM 0.822826215318982 0.203536478060162 no 702 0.205303413270493 995 368090 SGTC_2952 9073731 13.78 µM 0.821895770772929 0.203797794844728 no 703 0.205568110100171 1072 16457353 SGTC_2960 9079389 5.97 µM 0.818820639408704 0.204662871825134 no 704 0.206444376754923 1013 16457355 SGTC_69 0096-0274 206.684 µM 0.816391371674886 0.205347800413265 no 705 0.207138164965562 1140 6741392 SGTC_2247 cerulenin 830 nM 0.816212012651666 0.205398424350404 no 706 0.207189443731822 1031 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2396 5342950 42.78 µM 0.816195929950082 0.20540296404181 no 707 0.207194042144914 1008 1886677 SGTC_208 k072-0098 12.366 µM 0.812516775764772 0.206443050427083 no 708 0.208247582255222 1091 5948901 SGTC_2060 5238662 140 µM 0.810736929270424 0.206947325817632 no 709 0.208758380530849 959 790130 SGTC_2766 oltipraz 83.91 µM 0.810343241193153 0.207058965949516 no 710 0.20887146474096 984 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_140 0062-0056 502.533 µM 0.809310754624855 0.207351922630819 no 711 0.209168210838897 1087 3758964 SGTC_2056 5235370 200 µM 0.808718573136773 0.207520058126967 no 712 0.209338521170715 968 5511916 SGTC_3328 9140624 29.0385 µM 0.807751175067547 0.207794900488111 no 713 0.209616918604855 1053 4904392 SGTC_1021 4476-0760 85.3 µM 0.80675588415355 0.208077891595643 no 714 0.20990357016218 1028 746768 SGTC_229 benomyl 22.8748 µM 0.805738384684535 0.20836743228004 no 715 0.210196855981555 1028 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2199 6590217 200 µM 0.805110145344935 0.20854632330867 no 716 0.210378060901555 978 703109 SGTC_174 3553-0389 74.3 µM 0.80462173361478 0.208685460996694 no 717 0.210518998275105 987 738071 SGTC_1160 4092-0570 10.5 µM 0.801128044934789 0.20968232994465 no 718 0.211528760970871 1015 4994975 SGTC_1234 0326-0494 15.5 µM 0.799945899934999 0.210020269384322 no 719 0.211871071254378 1048 1547813 SGTC_1800 st050079 29.0735 µM 0.799398226386392 0.210176941072149 no 720 0.212029769274715 1082 3645560 SGTC_2729 fluphenazine 10.66 µM 0.798421628118335 0.210456484531082 no 721 0.212312928194679 1043 3372 An atypical antipsychotic. SGTC_211 3455-0679 143.504 µM 0.797976164750223 0.210584067307786 no 722 0.212442161035082 1068 748649 SGTC_2168 5727979 200 µM 0.797912960368748 0.210602173011903 no 723 0.212460500904196 996 695210 SGTC_1287 0971-0001 34.6 µM 0.796074508400957 0.211129220697333 no 724 0.212994364882233 1053 4665869 SGTC_204 PMA1.184 62.41 µM 0.795740259625812 0.211225126162571 no 725 0.213091510662011 1101 2252213 YGL008C PMA1 SGTC_1835 st008666 49.2 µM 0.795671031670393 0.21124499281922 no 726 0.213111634246615 945 690455 SGTC_2441 5730946 39.09 µM 0.794821480598189 0.21148888143601 no 727 0.213358676950377 1037 1774275 SGTC_265 mycophenolic acid 32.932 µM 0.792645167968482 0.212114407653169 no 728 0.213992292491278 1110 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1636 st007707 68.9 µM 0.788876603604847 0.213200141210903 no 729 0.215092065694167 1077 403051 SGTC_1973 st070275 50.2 µM 0.788448611805316 0.21332365141586 no 730 0.215217172916082 1032 17118334 SGTC_965 1291-5240 308 µM 0.787582861526245 0.213573617801907 no 731 0.215470371363894 1043 2834598 SGTC_732 3970-1727 52.7 µM 0.786370527392334 0.213923939340974 no 732 0.215825222405871 1060 1275699 SGTC_2041 5107442 45.335 µM 0.784058103089546 0.214593074736513 no 733 0.216503008915536 1078 793005 SGTC_708 3448-5400 146 µM 0.781909545276691 0.21521588178481 no 734 0.217133867465413 1081 3462195 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.781295151514242 0.215394170125149 no 735 0.217314460554652 1096 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2325 6158266 200 µM 0.781157997529557 0.215433981958881 no 736 0.217354787031887 1066 3623240 SGTC_1155 4088-0394 48.2 µM 0.777185795073778 0.216588848185203 no 737 0.218524580841438 1056 2326248 SGTC_2835 9006588 71.43 µM 0.776419490660467 0.216812052617727 no 738 0.218750670079794 1005 2345538 SGTC_1440 4100-1550 40 µM 0.775546370478538 0.217066531712703 no 739 0.219008438068484 1109 742806 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.773821076141251 0.217569892143511 no 740 0.219518303548801 1135 66535 A nucleotide analog. SGTC_2190 6049624 200 µM 0.772895050183515 0.217840340924132 no 741 0.219792247183342 1036 2265554 SGTC_2818 7996756 12.99 µM 0.77249097919241 0.217958411857433 no 742 0.219911843829583 1069 2241621 SGTC_811 0416-0114 265 µM 0.771436723846608 0.21826664256603 no 743 0.22022405735104 1067 6612453 SGTC_266 formosanin C 406 nM 0.770738271475232 0.218470986043512 no 744 0.220431041141532 1084 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1876 myriocin 605 nM 0.770484680049598 0.218545205547701 no 745 0.220506219609055 1094 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_441 propafenone 146 µM 0.768499271867073 0.219126783566489 no 746 0.221095311542115 1087 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_483 fpl-64176 144 µM 0.768114762520208 0.219239519184815 no 747 0.221209503597327 1099 3423 SGTC_2445 5742597 35.57 µM 0.76800940648615 0.219270414700844 no 748 0.22124079824865 1032 1774255 SGTC_1087 pterostilbene 9.05 µM 0.76800304744482 0.219272279561281 no 749 0.221242687200911 1100 5281727 Similar to reservatol, lowers cholesterol. SGTC_2607 solasodine 47.35 µM 0.764395107871303 0.220331817376804 no 750 0.222315911610152 1090 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1372 2752-0194 270 µM 0.761879813221295 0.22107221302911 no 751 0.223065869604625 1039 823334 SGTC_1864 st057645 30.4 µM 0.761557908197507 0.221167070819216 no 752 0.223161952392973 1131 688666 SGTC_2593 nobiletin 86.24 µM 0.760425745194841 0.221500877364427 no 753 0.223500069534449 1050 72344 An anti-infammatory. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.759916248357198 0.221651191150613 no 754 0.223652324289188 1169 23665772 A membrane-active detergent. SGTC_1121 fusaric acid 630.51 nM 0.759266493388742 0.221842968989903 no 755 0.223846578419952 1064 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_112 phenothiazine 287.218 µM 0.75918178746324 0.221867977271752 no 756 0.223871909608282 1113 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2926 9010726 65.15 µM 0.758448778081962 0.222084455645481 no 757 0.2240911830714 1108 2994293 SGTC_83 0170-0301 39.027 µM 0.756882073503345 0.222547551779409 no 758 0.224560258072335 1055 3089716 SGTC_1520 flindersine 88 µM 0.755361840207102 0.222997437522211 no 759 0.225015951513446 1147 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3083 9117465 49.47 µM 0.75396727506723 0.223410589164772 no 760 0.225434436097308 1124 16420915 SGTC_1832 st054113 55 µM 0.748741607898535 0.224962604730752 no 761 0.227006480124028 1100 1251267 SGTC_1338 1486-1223 76 µM 0.748221261015179 0.225117480832352 no 762 0.227163354433095 1125 3444526 SGTC_2981 9013952 38.96 µM 0.74700183632227 0.225480667091873 no 763 0.227531226189327 1077 2996344 SGTC_682 0kpi-0099 17 µM 0.745816132605119 0.225834127911421 no 764 0.227889246595855 1140 1714895 YML126C ERG13 SGTC_828 2074-0507 139 µM 0.74075480994844 0.227346437731242 no 765 0.229421059880387 1146 X828 SGTC_2571 chrysanthemic acid 100 µM 0.740321189233606 0.227476267277789 no 766 0.229552563374424 1078 2743 An insecticide. SGTC_3289 9119912 71.43 µM 0.739760779378693 0.227644120358894 no 767 0.229722580561342 1143 17014829 SGTC_3184 9108758 49.47 µM 0.739297661823157 0.227782885209598 no 768 0.229863134405836 1128 902885 SGTC_874 0599-0792 117 µM 0.737787563697122 0.228235689499603 no 769 0.230321775851196 1174 765305 SGTC_2062 5245942 200 µM 0.736998146018425 0.228472598356868 no 770 0.230561738408955 1221 1376160 SGTC_980 1473-0395 201 µM 0.736162217456935 0.228723615938248 no 771 0.230815991305681 1089 768876 SGTC_250 brefeldin a 552.239 µM 0.735956490230212 0.22878541666358 no 772 0.230878588529489 1040 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1833 st055984 71 µM 0.733422689883093 0.229547341825791 no 773 0.231650332240982 1130 676288 SGTC_2906 7926292 26.41 µM 0.731963231596086 0.22998685197979 no 774 0.232095505052774 1129 2966319 SGTC_237 nikkomycin 200 µM 0.729506952444381 0.230727613060486 no 775 0.23284580826381 1158 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_876 0720-0963 56.8 µM 0.729416100917208 0.230755037467403 no 776 0.232873585893566 1159 765861 SGTC_729 4092-0585 94.1 µM 0.728736877676722 0.230960125212785 no 777 0.233081315039065 1148 2169061 SGTC_752 1896-0090 130 µM 0.728403747028052 0.231060749373283 no 778 0.233183235107776 1135 772567 SGTC_2756 carbadox 75.1 µM 0.727938425827224 0.231201343452588 no 779 0.233325639781366 1140 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_107 0358-0022 2.6945 µM 0.727348119602171 0.231379769687537 no 780 0.233506363693889 1086 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2240 6690706 185.951 µM 0.726699695572634 0.231575851109649 no 781 0.233704969984592 1069 805876 SGTC_2309 7664088 163.95 µM 0.726196627673125 0.23172804107002 no 782 0.233859119520878 1161 704922 SGTC_2370 9071495 200 µM 0.724555053691532 0.232225043514152 no 783 0.234362520568555 1105 21791103 SGTC_2779 methotrexate 400 µM 0.723945768727746 0.232409661273638 no 784 0.234549514882461 1228 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3013 9080133 71.4286 µM 0.722334549802367 0.232898265440161 no 785 0.235044408011464 1211 17050193 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.721665931844288 0.233101192084764 no 786 0.235249946255063 1226 65057 A dermal irritant. YDR527W RBA50 SGTC_3310 9130229 44.1445 µM 0.72134847314979 0.233197575677996 no 787 0.235347570205482 1136 7761258 SGTC_2703 st077852 53.4 µM 0.721183597544278 0.233247642266023 no 788 0.235398281081411 1134 6281836 SGTC_2473 5854593 8.94 µM 0.717709275182062 0.234304051016295 no 789 0.236468281557157 1111 2872951 SGTC_423 5-fluorouracil 457 µM 0.716065256925491 0.23480485573976 no 790 0.236975527721225 1143 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_556 4058-0063 51.5 µM 0.715703512642907 0.234915130506281 no 791 0.237087220694664 1211 6615692 SGTC_3280 9140961 49.47 µM 0.714928443765625 0.235151500197011 no 792 0.237326630052138 1145 4901226 SGTC_704 1310-0270 142 µM 0.714519200298656 0.235276358526084 no 793 0.237453093920933 1162 5718033 SGTC_3344 9148862 3.898 µM 0.712739478413405 0.235819769084332 no 794 0.238003491215863 1192 4905352 SGTC_65 0798-0905 34.986 µM 0.712636150036658 0.235851340045621 no 795 0.238035468044871 1234 3602145 SGTC_1107 amlodipine 47 µM 0.710790862015055 0.236415541692085 no 796 0.238606922046561 1091 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1648 st011736 69.8 µM 0.710534060836418 0.236494118173322 no 797 0.238686508433503 1187 2855514 SGTC_1477 0139-0234 16 µM 0.710089234104762 0.236630261052028 no 798 0.238824401014534 1162 620880 SGTC_2620 irigenin 100 µM 0.709271207026742 0.236880737480424 no 799 0.239078096300169 1196 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1721 st082152 9.2685 µM 0.708991176554425 0.236966515104443 no 800 0.239164976170922 1152 5296051 SGTC_748 act1.228 77.9 µM 0.707397039919485 0.237455148674678 no 801 0.23965988795886 1158 4421505 YNR035C ARC35 SGTC_3133 9127736 49.47 µM 0.707124696842623 0.237538682355913 no 802 0.239744494796015 1186 27243420 SGTC_837 0091-0265 12.5 µM 0.707076021064174 0.237553613998905 no 803 0.239759618261631 1144 759367 SGTC_709 3807-1509 243 µM 0.706861843566868 0.237619320596672 no 804 0.239826168959296 1208 1886677 YPL242C IQG1 SGTC_1868 st057644 42.7 µM 0.706585653092926 0.237704066609971 no 805 0.239912003627881 1203 688665 SGTC_1387 3342-1166 1.8 µM 0.706581906365988 0.23770521636596 no 806 0.239913168153477 1136 3418228 SGTC_2101 5377231 179.231 µM 0.706573006879855 0.237707947358497 no 807 0.239915934227938 1176 2844213 SGTC_2034 5197015 53.07 µM 0.70468614269857 0.238287359438454 no 808 0.240502788429878 1171 780676 SGTC_400 oxethazaine 37.5 µM 0.704160600100604 0.238448878973914 no 809 0.240666382236518 1131 4621 A local anesthetic. SGTC_1289 0976-0073 69.1 µM 0.703654635481196 0.238604438060337 no 810 0.240823938912169 1208 3391136 SGTC_479 n-linoleoylglycine 10 µM 0.703540486314122 0.23863954095861 no 811 0.24085949256059 1186 6433346 An anti-infammatory. SGTC_2144 5628481 200 µM 0.703326616168551 0.238705317437909 no 812 0.24092611364564 1177 2818399 SGTC_935 2996-0153 430 µM 0.703108296459997 0.238772472625567 no 813 0.240994131117535 1194 23738523 SGTC_3139 9095020 49.47 µM 0.702972720056391 0.238814181156928 no 814 0.241036375180988 1011 25236292 SGTC_1463 k081-0032 34.1 µM 0.702672221478832 0.238906640314376 no 815 0.241130021467247 1035 977755 SGTC_2120 5538279 151.968 µM 0.702567544925786 0.238938852404221 no 816 0.241162647132785 1186 2058197 SGTC_1706 st031321 9.9705 µM 0.701139936137487 0.239378407084326 no 817 0.241607844735544 1205 6103185 SGTC_399 oxolinic acid 75 µM 0.701018337755404 0.239415867109652 no 818 0.241645785615309 1169 4628 A DNA gyrase inhibitor. SGTC_1850 st056238 17 µM 0.697059773056921 0.240637103315261 no 819 0.242882693769874 1209 5393177 SGTC_1225 1216-0074 20.6 µM 0.695764479453379 0.241037442689479 no 820 0.243288168752009 1187 4241466 SGTC_2514 salinomycin 42.74 µM 0.694421501244452 0.241452902173938 no 821 0.24370895680341 1235 23682228 A polyether potassium ionophore. SGTC_823 0417-1665 178 µM 0.694150107775363 0.241536906816341 no 822 0.243794038740621 1219 3429856 SGTC_2257 7960413 200 µM 0.693774963009127 0.241653051809963 no 823 0.24391167313457 1183 2974689 YIL048W NEO1 SGTC_2526 patulin 37.61 µM 0.693708117671824 0.241673750339482 no 824 0.243932637085846 1235 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1611 st001856 99.4 µM 0.693542497745199 0.24172503837577 no 825 0.243984582788694 1170 647478 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.693260089493004 0.241812506238681 no 826 0.244073172215562 1199 5357218 A potent inhibitor of glutathione S-transferases. SGTC_860 0443-0016 25.1 µM 0.689438711731707 0.242997755308115 no 827 0.245273614645412 1227 5337942 SGTC_1752 st044819 83.042 µM 0.689272193914257 0.243049474287915 no 828 0.245325996398723 1169 441209 YML126C ERG13 SGTC_288 1315-0019 35.1 µM 0.689130868397126 0.243093373429377 no 829 0.245370458090203 1229 6811474 SGTC_1290 0986-0249 10.2 µM 0.688930276504766 0.243155689509209 no 830 0.245433572705176 1171 53329 SGTC_825 1988-2224 89.6 µM 0.688773683348946 0.243204342899683 no 831 0.245482849536557 1203 1180859 SGTC_484 loperamide 105 µM 0.688736530598485 0.243215887007223 no 832 0.245494541567259 1161 3955 An opioid-receptor agonist. SGTC_2957 9076800 11.52 µM 0.687653398407972 0.24355256815239 no 833 0.245835536489233 1153 16459615 SGTC_3333 9141820 12.094 µM 0.685258213204032 0.244297981208635 no 834 0.246590497713997 1191 1939433 SGTC_2119 5528445 120.635 µM 0.684854209742237 0.244423833478396 no 835 0.246717961705289 1211 791935 SGTC_2071 5230951 39.92 µM 0.684438774094102 0.244553283443979 no 836 0.246849069360038 1264 1799272 SGTC_95 0471-0001 561.058 µM 0.683937181482365 0.244709629162234 no 837 0.247007417040794 1156 4015405 SGTC_1150 3909-7983 10.9 µM 0.683176966545246 0.244946689654368 no 838 0.247247512723671 1213 23965914 SGTC_2068 5226020 147 µM 0.682615355583973 0.245121898102191 no 839 0.247424964208534 1244 1810509 SGTC_1806 st050005 60.3 µM 0.682204330327444 0.245250170313364 no 840 0.247554878447198 1198 5194765 SGTC_1671 st016596 74.5 µM 0.681810095203541 0.245373236581249 no 841 0.247679519999544 1255 2829167 SGTC_3038 9091290 49.47 µM 0.679085043573789 0.24622480820907 no 842 0.248541989258876 1244 25236843 SGTC_757 1066-0008 322 µM 0.678296502349889 0.246471520605789 no 843 0.248791857953061 1224 6842497 SGTC_2565 isoliquiritigenin 100 µM 0.677517378184896 0.246715416704388 no 844 0.249038873917205 1178 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2717 st081029 62.2815 µM 0.677286703480339 0.246787651626208 no 845 0.249112032775354 1205 5292846 SGTC_678 1218-2179 85.9 µM 0.67589466941137 0.247223802121375 no 846 0.249553761195843 1224 6820081 YOR116C RPO31 SGTC_1330 1469-0054 61.8 µM 0.674490759476595 0.247664090669745 no 847 0.249999679274407 1244 7102664 SGTC_1701 st028638 40.4 µM 0.671673413286231 0.248548917328449 no 848 0.250895815278735 1219 3490878 SGTC_1310 1188-0297 994 nM 0.671228263419645 0.248688876738212 no 849 0.251037563068842 1193 1588352 SGTC_937 3122-0005 46.7 µM 0.670843320472857 0.248809940345011 no 850 0.251160173497152 1226 759535 SGTC_1175 0741-0056 27.6 µM 0.670818855732632 0.248817635505709 no 851 0.251167966974909 1284 765927 SGTC_688 0527-0193 473 µM 0.668485365452057 0.249552195604624 no 852 0.251911910233995 1242 4007154 SGTC_1987 st072290 61.9 µM 0.668120444058435 0.249667173406679 no 853 0.252028356397216 1247 54697379 SGTC_2253 7938677 135.83 µM 0.668061403397977 0.249685778318108 no 854 0.252047198899771 1281 2301972 SGTC_1100 amiodarone 5.07 µM 0.667141316502375 0.249975811512642 no 855 0.252340935596489 1269 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2402 5553605 200 µM 0.666989933179415 0.250023548245376 no 856 0.252389281832743 1279 6758546 SGTC_945 3381-0768 11.3 µM 0.666840625842615 0.25007063508077 no 857 0.252436969857636 1250 1126236 YIL048W NEO1 SGTC_2358 9037157 4 µM 0.666540457582805 0.25016531293847 no 858 0.252532856483116 1257 2388925 SGTC_627 1391-0720 175 µM 0.666261067366796 0.250253454150222 no 859 0.252622122949882 1203 997839 SGTC_510 ag-490 170 µM 0.664904751846713 0.250681574522591 no 860 0.253055708118872 1344 5328779 SGTC_3334 9142812 21.919 µM 0.663921456573805 0.250992193600589 no 861 0.253370291295 1268 45283678 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.663697002498182 0.25106312629388 no 862 0.253442129126783 1301 94937 An inhibitor of serotonin biosynthesis. SGTC_2355 9061122 103.12 µM 0.661439219028462 0.251777227724514 no 863 0.254165340794444 1236 5302957 SGTC_1913 st060213 96.1 µM 0.65947129954976 0.252400523370586 no 864 0.254796585101825 1273 688959 SGTC_2179 6298986 200 µM 0.656533540165409 0.253332505771748 no 865 0.255740447250211 1220 738374 SGTC_1851 st056236 18.9 µM 0.654716595793001 0.253909822040582 no 866 0.256325119086567 1269 5393171 SGTC_1296 1068-0102 11.9 µM 0.653417120959018 0.254323140545696 no 867 0.256743702082075 1232 767053 SGTC_904 1141-0088 396 µM 0.653334631579326 0.254349389496082 no 868 0.256770285323692 1199 1378119 SGTC_2049 5262831 67.185 µM 0.65225447022162 0.254693238707336 no 869 0.257118513098263 1290 763417 SGTC_985 1493-0307 8.71 µM 0.651138810478246 0.255048643548045 no 870 0.257478442673669 1245 3278274 SGTC_1351 1496-0003 46.5 µM 0.650208303342323 0.255345264434534 no 871 0.257778839138654 1261 3891978 SGTC_2930 9013230 14.89 µM 0.649474002916052 0.255579467072701 no 872 0.258016022361976 1257 2995857 SGTC_2786 7743617 45.45 µM 0.647783480747444 0.256119079603828 no 873 0.258562500613641 1190 583674 SGTC_1694 st024011 44.9 µM 0.645714466160312 0.256780314136523 no 874 0.259232145113106 1322 2787533 SGTC_2385 9074692 200 µM 0.645697323152209 0.256785796564731 no 875 0.259237697255195 1253 17046906 SGTC_3222 9128301 49.47 µM 0.64545889617239 0.256862053139402 no 876 0.259314923473656 1297 4911358 SGTC_877 0771-0151 33.1 µM 0.644406173447361 0.257198888375813 no 877 0.259656041184564 1303 6166523 SGTC_1504 k297-0033 30 µM 0.644315093874091 0.257228041511474 no 878 0.259685564925272 1184 4388117 SGTC_1916 st067606 49.2 µM 0.641969660081763 0.257979369180855 no 879 0.260446441322914 1304 19590279 SGTC_130 0136-0219 337.655 µM 0.641212499916757 0.258222157929288 no 880 0.260692314707209 1248 234244 SGTC_815 1582-0027 36.9 µM 0.641104481653757 0.258256804398764 no 881 0.260727401320711 1315 3128206 SGTC_1606 st000094 49.2 µM 0.640849099130101 0.258338727006229 no 882 0.260810364621944 1313 1242210 SGTC_822 1487-0950 154 µM 0.640712432303544 0.258382573057564 no 883 0.260854767643156 1291 1958375 SGTC_3232 9132874 49.47 µM 0.640440642320058 0.258469781370462 no 884 0.260943083702485 1249 3784940 SGTC_3159 9100096 49.47 µM 0.640336498097141 0.258503201807375 no 885 0.26097692863904 1242 25236875 SGTC_3082 9117008 49.47 µM 0.640153905482492 0.258561802153465 no 886 0.261036273292294 1286 41448529 SGTC_609 0986-0026 86.3 µM 0.640132303237139 0.258568735523391 no 887 0.261043294723905 1293 2848610 SGTC_696 1560-0013 611 µM 0.639790804258174 0.258678354454238 no 888 0.261154305886253 1322 1650269 SGTC_1258 0671-0043 57.1 µM 0.639668812373232 0.258717518879807 no 889 0.261193967700944 1269 4298767 SGTC_320 4092-0846 5.34 µM 0.639648988527089 0.258723883441774 no 890 0.261200413091779 1263 1359356 SGTC_287 k060-0039 29.6 µM 0.638516404077773 0.259087640850793 no 891 0.261568789591536 1322 5861974 SGTC_218 alverine citrate 93.75 µM 0.637834003996908 0.259306938049627 no 892 0.261790870945591 1298 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_506 n9-isopropylolomoucine 153 µM 0.637284020650935 0.259483751367962 no 893 0.261969928754757 1294 6610355 SGTC_2570 licareol 100 µM 0.637232017580552 0.259500472978349 no 894 0.261986862617638 1252 443158 SGTC_760 0568-0725 82.9 µM 0.636145621855903 0.259849931213059 no 895 0.262340756086503 1294 3916171 SGTC_1241 0364-0022 50.8 µM 0.635904893918066 0.259927398421665 no 896 0.262419206347665 1318 4563895 SGTC_3172 9105863 49.47 µM 0.63575207372986 0.259976582747162 no 897 0.26246901479155 1264 2348785 SGTC_507 nimesulide 162 µM 0.635751118852261 0.259976890084282 no 898 0.26246932602852 1334 4495 A COX2 inhibitor. SGTC_1063 disulfiram 1.84 µM 0.63479768669256 0.260283855444223 no 899 0.262780186116971 1282 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3299 9121982 43.1275 µM 0.634044110498265 0.260526607592919 no 900 0.263026017692178 1298 17594604 YPL160W CDC60 SGTC_2614 arthonioic acid 13.39 µM 0.630845503219582 0.261558282143302 no 901 0.264070773815958 1248 6710684 SGTC_2972 9093619 59.92 µM 0.630575736552875 0.261645388121324 no 902 0.264158983866649 1269 25236256 SGTC_1341 1486-1360 280 µM 0.630547306759913 0.261654568791606 no 903 0.264168280898503 1290 3976547 SGTC_1625 st003711 30.1 µM 0.629357094569096 0.262039065474732 no 904 0.264557650266589 1372 24207034 YER133W GLC7 SGTC_1202 1988-0068 29.6 µM 0.628335873351995 0.262369200523845 no 905 0.264891968038012 1242 2850480 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.627165524972851 0.262747806368491 no 906 0.265275369523642 1359 165506 SGTC_1727 st034309 9.9045 µM 0.626791592252688 0.262868831892922 no 907 0.265397927757493 1388 870305 SGTC_1448 4255-0083 152 µM 0.626654924503307 0.26291307232583 no 908 0.265442728433929 1381 5399660 SGTC_1390 3413-2614 145 µM 0.625919154954444 0.263151312151526 no 909 0.265683984933663 1302 3421432 SGTC_1607 st000305 50.6 µM 0.624486540122668 0.263615504495065 no 910 0.266154053571313 1350 5457690 SGTC_1344 1488-0097 29.1 µM 0.622819911303557 0.264156046683549 no 911 0.266701436120728 1314 747966 SGTC_447 ml7 120 µM 0.622604658913087 0.264225901213398 no 912 0.266772174439656 1324 4216 Selective myosin light chain kinase inhibitor. SGTC_3300 9124615 50.48 µM 0.621647815340591 0.264536533567272 no 913 0.267086736327326 1367 24824903 SGTC_1283 0922-0125 16.4 µM 0.621491887849063 0.264587171902097 no 914 0.267138015158907 1301 3360884 SGTC_1575 cyproterone acetate 48 µM 0.620467431650174 0.264919992430834 no 915 0.267475044766932 1261 9880 An androgen receptor antagonist and liver toxin. SGTC_2424 5537928 59.2 µM 0.618494351415909 0.265561596438085 no 916 0.26812476005636 1335 5382802 SGTC_785 1270-0111 65.3 µM 0.615906185768319 0.266404406605789 no 917 0.268978219367227 1303 6741994 SGTC_2009 4012297 12.05 µM 0.612676899663969 0.267457885520497 no 918 0.270044999872357 1314 45595307 SGTC_2544 sphondin 68.51 µM 0.611044139691668 0.267991333741404 no 919 0.270585179563708 1361 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1036 k216-0215 33.5 µM 0.610635793757843 0.268124830439974 no 920 0.270720360401621 1311 622330 SGTC_513 4245-1575 41.7 µM 0.610249268957667 0.26825122418747 no 921 0.270848348522356 1294 719745 SGTC_24 0417-1663 219 µM 0.609934930201971 0.268354035169548 no 922 0.270952456283069 1305 4329390 SGTC_800 3448-7362 155 µM 0.609738022601384 0.26841844796104 no 923 0.271017681475935 1395 15991913 SGTC_2624 nerol 100 µM 0.608792206791973 0.26872795336031 no 924 0.271331089928102 1303 637566 A natural product oil. SGTC_3229 9132204 49.47 µM 0.608222699414107 0.268914403368475 no 925 0.271519890736569 1337 17682924 SGTC_1429 4049-0205 9.46 µM 0.608160272715634 0.268934845083701 no 926 0.271540590164607 1358 22774478 SGTC_9 0092-0002 10.449 µM 0.606830423534294 0.269370491413051 no 927 0.271981727805933 1325 759368 SGTC_2978 9011784 42.97 µM 0.606766847529315 0.269391327184705 no 928 0.272002826165538 1400 2994934 SGTC_2106 5357045 167.29 µM 0.60341559819634 0.270490775075779 no 929 0.27311612406136 1383 668842 SGTC_2438 5259590 200 µM 0.603334088622483 0.270517543909664 no 930 0.273143229959555 1339 1201127 SGTC_1206 3978-0017 132 µM 0.602549852059764 0.270775165291875 no 931 0.273404094860833 1411 3873677 SGTC_1704 st028805 70.8 µM 0.601653431962701 0.271069788851917 no 932 0.273702426995946 1325 2876101 SGTC_2395 5646831 180.19 µM 0.601208491113272 0.27121608550761 no 933 0.27385056483888 1390 6808628 SGTC_2569 tetrandrine 100 µM 0.598598159688935 0.272075155144775 no 934 0.274720441784567 1292 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1078 idebenone 36.1 µM 0.596409832994954 0.272796382495776 no 935 0.27545073658568 1350 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1291 0993-0025 5.79 µM 0.596351570414881 0.272815597594893 no 936 0.275470193189337 1401 4353356 SGTC_1128 3448-9350 235 µM 0.596258206719842 0.272846390501998 no 937 0.275501373108533 1340 619386 SGTC_1762 st045503 25.4615 µM 0.594922618325362 0.273287078507452 no 938 0.275947598714792 1354 4645554 SGTC_1325 1431-0015 227 µM 0.594851109035223 0.273310683505912 no 939 0.275971500272901 1272 1103340 SGTC_82 0054-0107 293.755 µM 0.593288671544679 0.273826691285647 no 940 0.276493989444003 1353 3104697 SGTC_1052 3253-3998 198 µM 0.592229732104881 0.274176688383691 no 941 0.276848381165257 1318 5450317 SGTC_2743 auranofin 4.32 µM 0.591955016834844 0.27426752243392 no 942 0.276940355535544 1331 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_279 1273-0055 2.93 µM 0.591857077118139 0.274299909596643 no 943 0.276973149262182 1382 2847562 SGTC_1244 0416-0015 52.5 µM 0.591515027377641 0.274413035012903 no 944 0.277087694683602 1368 96201 SGTC_1503 4585-0012 61.3 µM 0.590919026192577 0.274610204276614 no 945 0.277287338592913 1386 2922052 SGTC_707 0865-0008 204 µM 0.590868300701185 0.274626988522836 no 946 0.277304333477277 1394 723043 SGTC_913 3487-1245 167 µM 0.587206042536401 0.275840105866292 no 947 0.2785326673169 1299 4016153 SGTC_1642 st009582 77.7 µM 0.587080749559133 0.275881655505676 no 948 0.278574737851108 1396 6739311 SGTC_954 1189-0853 2.85 µM 0.585496495468854 0.276407290693892 no 949 0.279106961180722 1342 2828194 SGTC_1102 cgs 12066b 26.1 µM 0.585320942365484 0.27646556717791 no 950 0.27916596790229 1344 6438352 A 5-HT1B full agonist. SGTC_2245 6637752 200 µM 0.584432327793266 0.276760643442366 no 951 0.279464741083863 1362 681890 SGTC_1952 st077036 64.1 µM 0.584293514636837 0.276806752123239 no 952 0.279511427361697 1350 2937007 SGTC_2415 st077333 57.7 µM 0.583834721571866 0.276959173253916 no 953 0.279665757688357 1517 2766255 SGTC_2072 5231554 129 µM 0.582913100333987 0.277265480188027 no 954 0.279975900606563 1414 789545 SGTC_2008 4012253 172 µM 0.580725769676666 0.277993116642411 no 955 0.280712645439955 1372 603940 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.580364967715727 0.278113230330532 no 956 0.280834262131218 1342 4174840 SGTC_1187 1391-0724 117 µM 0.580227940621663 0.278158854313143 no 957 0.28088045697346 1380 6997986 SGTC_3301 9125354 19.7965 µM 0.579524180676489 0.278393232854457 no 958 0.281117767765597 1357 41905162 SGTC_2897 9048598 12.99 µM 0.576778995079127 0.279308401775276 no 959 0.282044380386 1343 6467404 SGTC_1662 st014054 52 µM 0.573471596777717 0.280412934679317 no 960 0.283162712596153 1360 2838777 SGTC_2128 5255449 168.493 µM 0.572922060749604 0.280596661432182 no 961 0.283348733395714 1344 736008 SGTC_1016 4226-1401 38 µM 0.572325404994993 0.280796207683155 no 962 0.283550770791665 1364 2901613 SGTC_2306 7482397 179.52 µM 0.572071154072893 0.280881260505091 no 963 0.283636885281764 1463 891448 SGTC_1841 st054148 70 µM 0.570471513780986 0.281416662702512 no 964 0.28417896875101 1324 675442 SGTC_103 0844-0104 51.839 µM 0.569654471925721 0.281690317815783 no 965 0.284456037554693 1410 5375804 SGTC_2867 9039098 71.43 µM 0.569133907488754 0.281864739441269 no 966 0.284632634548627 1354 6463460 SGTC_278 4092-0821 23.9 µM 0.568278116333802 0.282151596020273 no 967 0.284923068024302 1397 877900 SGTC_1417 3966-0327 90.4 µM 0.567047979594635 0.282564177249363 no 968 0.28534079220849 1426 651118 SGTC_3114 9122766 49.47 µM 0.565205179539426 0.283182784590115 no 969 0.285967107047024 1337 17176985 SGTC_2990 9074105 71.4286 µM 0.564348257171768 0.283470664979086 no 970 0.286258572767969 1395 6502001 SGTC_3065 9113888 49.47 µM 0.558764584727791 0.285349908902325 no 971 0.288161197697211 1456 16648368 SGTC_668 1682-0499 62.6 µM 0.5560038262571 0.286281258464161 no 972 0.289104119542878 1418 682214 SGTC_387 norethindrone acetate 66.7 µM 0.55457190685068 0.286764888244586 no 973 0.289593754518527 1404 541197 SGTC_770 0389-1121 67.2 µM 0.554188525478568 0.286894440733871 no 974 0.289724915179828 1499 6753108 SGTC_158 k038-0087 26.446 µM 0.554038793351812 0.286945045843651 no 975 0.289776148411028 1424 X158 SGTC_1631 benzylvanillin 81.9 µM 0.553782175153889 0.287031785173831 no 976 0.289863964297333 1442 75506 SGTC_255 tunicamycin 200.472 nM 0.552983781580628 0.287301728992643 no 977 0.290137257921457 1416 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_36 0335-0881 14.2 µM 0.552870899201601 0.287339905198576 no 978 0.290175907795943 1386 23828853 SGTC_3086 9117350 49.47 µM 0.552740885560001 0.287383878077992 no 979 0.290220426244132 1343 2679265 SGTC_378 3970-0959 8.33 µM 0.552461710050238 0.287478310855665 no 980 0.290316030565217 1406 6615653 SGTC_1153 4055-0057 267 µM 0.55146814513792 0.287814509086151 no 981 0.290656398840637 1368 882706 SGTC_2767 sibutramine 71.45 µM 0.55002916182372 0.288301755085756 no 982 0.291149686000303 1496 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2497 7-hydroxyflavone 100 µM 0.544826552759421 0.290066618700257 no 983 0.292936407346918 1447 5281894 SGTC_256 clotrimazole 625 nM 0.543726478299154 0.290440440848019 no 984 0.293314854377052 1407 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3329 9141233 27.5565 µM 0.541584339658764 0.291169018780533 no 985 0.294052441238199 1499 4909101 YNL103W MET4 SGTC_1410 3909-8106 77.9 µM 0.539057153089231 0.292029653728482 no 986 0.294923709531962 1464 1039210 SGTC_3171 9103192 49.47 µM 0.538616717286538 0.292179765510338 no 987 0.295075675034347 1457 13018434 SGTC_3107 9121808 49.47 µM 0.536322294601098 0.292962343495133 no 988 0.295867912449551 1398 662681 SGTC_2157 5649910 96.377 µM 0.534392170157865 0.293621419500529 no 989 0.296535117506989 1391 2858091 SGTC_2733 amorolfine 100 µM 0.533083579121658 0.294068651734795 no 990 0.296987862776725 1487 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_18 0111-0177 500 nM 0.531197118624493 0.294713933781978 no 991 0.297641094734269 1475 721752 SGTC_3161 9100388 49.47 µM 0.531109493555497 0.294743922647414 no 992 0.29767145293487 1503 25236368 SGTC_2539 epi(13)torulosol 80 µM 0.530585007624251 0.294923452492975 no 993 0.297853193583114 1417 6708597 SGTC_2435 5706476 10.6 µM 0.530268483855248 0.295031821936344 no 994 0.297962897331464 1478 5725375 SGTC_2942 9052777 62.25 µM 0.529787883415305 0.295196401992678 no 995 0.298129503500964 1505 6469503 SGTC_2111 5486399 200 µM 0.529538266479847 0.295281899173727 no 996 0.298216053083916 1425 689674 SGTC_167 3672-0051 66.205 µM 0.529345593618928 0.295347900030335 no 997 0.298282866293992 1394 3237971 SGTC_2787 5284540 71.43 µM 0.527413655412798 0.296010068102978 no 998 0.298953181374161 1465 736958 SGTC_2698 st077697 67.5 µM 0.526364014119475 0.296370116096198 no 999 0.299317656851229 1385 3154499 SGTC_838 0109-0203 71.4 µM 0.526157300070182 0.296441046813392 no 1000 0.299389459600053 1433 759422 SGTC_1830 st055982 50.3 µM 0.525942531017627 0.296514749720211 no 1001 0.299464068550948 1457 455313 An antimicrobial agent. SGTC_291 SEC14.278 35.5 µM 0.524746990776742 0.296925180042664 no 1002 0.299879543080378 1516 1068044 SGTC_3136 9095672 49.47 µM 0.524462089977098 0.297023025149566 no 1003 0.299978590384032 1377 17217380 SGTC_32 0928-0142 34.1 µM 0.523039133517923 0.29751193981998 no 1004 0.30047351034458 1426 2244242 SGTC_2156 5649887 115 µM 0.522441983287304 0.297717224509937 no 1005 0.300681315592832 1534 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_928 2764-0428 58.7 µM 0.522334706014812 0.297754110487679 no 1006 0.300718654411094 1504 662578 SGTC_546 peri-Naphthalide 147 µM 0.521285865104372 0.298114851379263 no 1007 0.301083823091517 1486 223824 A penicillin ester. SGTC_1215 3852-0577 11.2 µM 0.521015728015485 0.298207795221919 no 1008 0.301177907463593 1559 2884876 SGTC_3128 9127691 49.47 µM 0.519996679575011 0.29855852955635 no 1009 0.301532944691213 1461 41316314 SGTC_1435 4092-0789 56.7 µM 0.519241954039465 0.298818410567639 no 1010 0.301796012936513 1520 2248285 SGTC_1780 st038448 24.544 µM 0.51813484413713 0.299199816939093 no 1011 0.302182095332969 1550 728868 YDL195W SEC31 SGTC_679 0422-0091 41.4 µM 0.517884917216876 0.299285948900859 no 1012 0.302269283001309 1430 627384 YHR062C RPP1 SGTC_1318 1280-3875 124 µM 0.517540246934289 0.299404750582836 no 1013 0.302389540655799 1452 373245 SGTC_2697 mebhydrolin 72.4 µM 0.517526671466596 0.299409430241437 no 1014 0.302394277662051 1563 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_33 0986-0033 35.816 µM 0.516749909148108 0.299677246584443 no 1015 0.302665375518576 1449 2848082 SGTC_1558 st069300 45.6 µM 0.516600878834983 0.299728642472739 no 1016 0.302717401043589 1498 24208000 SGTC_2537 larixol 68.93 µM 0.51598728223079 0.299940294771676 no 1017 0.302931645864119 1480 6708759 SGTC_2970 9090938 41.86 µM 0.515340569271231 0.300163443318392 no 1018 0.303157527100772 1570 17217104 SGTC_2748 diazoxide 86.69 µM 0.514324304574701 0.300514257419591 no 1019 0.303512635942323 1487 3019 A potassium channel activatior. SGTC_77 0828-0286 12.516 µM 0.513865058478636 0.300672849680315 no 1020 0.303673169180557 1410 745345 SGTC_2020 4017018 200 µM 0.510926682631369 0.301688456973549 no 1021 0.304701198238604 1461 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1292 0kpi-0043 232 µM 0.5097233846967 0.302104804305777 no 1022 0.305122633825595 1446 3333905 SGTC_2854 9024559 71.43 µM 0.509182665865461 0.302291979798649 no 1023 0.305312096055201 1428 3163529 SGTC_2726 cimetidine 79.27 µM 0.506687755774937 0.303156292133195 no 1024 0.306186961552203 1483 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_157 1348-1695 65.819 µM 0.506247096121117 0.303309064738887 no 1025 0.306341598431065 1449 5380510 SGTC_2231 micatex 6.853 µM 0.506176808657278 0.303333435931019 no 1026 0.30636626699346 1499 20737 An antifungal of unknown mechanism. SGTC_1413 3910-0535 34.4 µM 0.504976537743113 0.30374974803619 no 1027 0.306787657556987 1537 2876951 SGTC_2391 6285546 200 µM 0.504410748568991 0.303946079513048 no 1028 0.306986383190047 1443 846083 SGTC_2479 5617353 43.85 µM 0.504188493117383 0.304023218666133 no 1029 0.307064462867782 1536 2731746 SGTC_2219 9098279 200 µM 0.503110913750869 0.304397342420871 no 1030 0.307443146985883 1506 902349 SGTC_660 4031-1742 102 µM 0.502750667212064 0.304522461767757 no 1031 0.307569791036433 1465 6738706 SGTC_3015 9080845 49.47 µM 0.501396327904282 0.304993049907017 no 1032 0.308046111814054 1586 5296973 SGTC_1050 3232-1156 69.3 µM 0.500833119451189 0.305188841268486 no 1033 0.30824428737069 1437 700529 SGTC_2439 5492030 7.2 µM 0.500238108622101 0.305395748845782 no 1034 0.308453713926884 1494 5722370 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.498605779669472 0.305963689976612 no 1035 0.309028566333466 1459 229346 A bile salt which induces apoptosis. SGTC_2707 st078556 66.6 µM 0.497602480449235 0.306313002652574 no 1036 0.309382127549576 1542 17250899 SGTC_2504 purpurogallin 52.29 µM 0.496758681095684 0.30660691958373 no 1037 0.309679617936941 1470 5281571 An antioxidant. SGTC_505 gw-5074 63.9 µM 0.496031898074904 0.306860176476499 no 1038 0.309935952962657 1559 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1002 4049-0206 172 µM 0.495479340874645 0.307052783850464 no 1039 0.310130900717346 1470 4662749 SGTC_3078 9116413 49.47 µM 0.495386364742481 0.307085198199171 no 1040 0.310163708882679 1412 17177322 SGTC_2656 pseudo-anisatin 100 µM 0.494788735293659 0.307293586249416 no 1041 0.31037462837877 1501 6708809 A neurotoxin. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.494447452443869 0.307412616452957 no 1042 0.310495104255374 1559 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3074 9116018 49.47 µM 0.492519671944209 0.308085354649716 no 1043 0.311176009364904 1530 17027303 SGTC_2645 abamectin 100 µM 0.490157546804461 0.308910545993415 no 1044 0.312011209560799 1521 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_48 0382-0018 55 µM 0.489586069086033 0.309110332803198 no 1045 0.312213418144443 1620 762596 SGTC_925 2064-1272 59.6 µM 0.488293614714012 0.309562378986815 no 1046 0.312670941819888 1470 6815817 SGTC_490 phenamil 164 µM 0.485920657533171 0.310393089751149 no 1047 0.313511710710196 1567 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_383 2324-0395 7.37 µM 0.485838289405379 0.310421942105648 no 1048 0.313540912225406 1560 3146421 SGTC_2091 4-phenylthiadiazole 200 µM 0.483248106468276 0.311329839808067 no 1049 0.314459790796291 1522 270010 SGTC_1690 st023502 41.2 µM 0.481542184643479 0.311928418693994 no 1050 0.315065602815635 1576 24207482 SGTC_1887 st057648 70.8 µM 0.480833830605907 0.312177114189369 no 1051 0.315317301965148 1616 688672 SGTC_2937 9044753 11.33 µM 0.480499248181197 0.312294612262426 no 1052 0.315436218821532 1458 6465530 YGL099W LSG1 SGTC_1587 estradiol valerate 56.1 µM 0.480120370652575 0.312427688862864 no 1053 0.315570902070157 1545 13791 A steroid. SGTC_3011 9081274 71.4286 µM 0.478896578140855 0.312857699716143 no 1054 0.316006102708519 1498 6625322 SGTC_532 1548-0774 215 µM 0.477765615831782 0.313255318841878 no 1055 0.316408518256745 1618 5932993 SGTC_1394 3474-0001 65.7 µM 0.47561170652592 0.314013181973809 no 1056 0.317175516897656 1466 5017666 YIL048W NEO1 SGTC_123 0083-0120 66.675 µM 0.474032288387645 0.314569406837124 no 1057 0.317738441226981 1439 16001701 SGTC_1067 clotrimazole 1.36 µM 0.472422801676293 0.315136654238936 no 1058 0.318312516096586 1513 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1177 0983-0204 23.6 µM 0.472349057875545 0.315162654960175 no 1059 0.318338829650578 1599 766818 SGTC_1784 st039334 36.3 µM 0.471212638569765 0.315563451435046 no 1060 0.318744447102578 1609 3496984 SGTC_1482 3346-2049 8.48 µM 0.468015081508847 0.316692340822779 no 1061 0.319886902319702 1562 3826804 SGTC_1814 st052110 31.539 µM 0.467314767691471 0.316939813381535 no 1062 0.320137346172556 1607 674163 SGTC_2619 obliquin 87.91 µM 0.466888351869157 0.317090537696514 no 1063 0.320289879712542 1596 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.465343686681309 0.317636781251484 no 1064 0.320842677227029 1563 77254 SGTC_2582 agaric acid 100 µM 0.462823706210336 0.318528780126144 no 1065 0.321745368722814 1439 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1314 1222-0010 41.1 µM 0.461110195967163 0.319135914012293 no 1066 0.32235977350041 1553 3526027 SGTC_75 0159-0059 199.013 µM 0.459326687945592 0.319768365282497 no 1067 0.322999792816709 1633 5377270 SGTC_2888 9058547 12.99 µM 0.458646734925113 0.32000962216059 no 1068 0.323243934996392 1490 16476514 SGTC_416 estradiol valerate 100 µM 0.458421183995055 0.320089667619273 no 1069 0.32332493755618 1545 13791 A steroid. SGTC_1863 st057641 20.1 µM 0.458302009525922 0.320131964664203 no 1070 0.323367740305467 1546 3921635 SGTC_1053 3366-3204 134 µM 0.457434229893869 0.320440024861918 no 1071 0.323679482839835 1502 3632071 YPR165W RHO1 SGTC_3055 9094636 49.47 µM 0.457250862148074 0.320505135925233 no 1072 0.323745372006651 1580 25236176 SGTC_233 rapamycin 362 pM 0.455780336792937 0.321027496500083 no 1073 0.324273972613163 1569 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2246 7293507 91.5585 µM 0.455066001496246 0.321281370913806 no 1074 0.324530878231538 1678 887656 SGTC_2652 actinonin 100 µM 0.45440890754991 0.321514975545527 no 1075 0.324767271161365 1552 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1210 3013-0140 750 nM 0.453933771861679 0.321683935865264 no 1076 0.324938247654345 1670 905973 SGTC_2461 5755302 26.15 µM 0.45294449744683 0.322035844477723 no 1077 0.325294354092628 1648 2788904 SGTC_101 0490-5701 117.494 µM 0.451676701925142 0.322487063075317 no 1078 0.325750952312636 1624 4661669 SGTC_3346 9158254 43.5805 µM 0.450911546726849 0.322759514585096 no 1079 0.326026650554461 1545 17639500 SGTC_1328 1441-0025 69.2 µM 0.449949319439359 0.323102273334658 no 1080 0.326373492204852 1456 4562601 SGTC_613 3914-0030 117 µM 0.44711140243956 0.324114053072199 no 1081 0.327397313288838 1508 1145395 SGTC_1889 st059080 5.18 µM 0.446789066856392 0.324229055167277 no 1082 0.327513683012307 1690 176925 Isolated from Daphnopsis sellowiana. SGTC_2955 9076254 12.21 µM 0.446351417481913 0.324385225475563 no 1083 0.327671710192491 1638 16459619 SGTC_3220 9131269 49.47 µM 0.446327378624535 0.32439380436956 no 1084 0.327680391078655 1564 17722206 SGTC_3164 9100705 49.47 µM 0.445103271893126 0.324830781952911 no 1085 0.328122562217597 1623 17174235 SGTC_857 0438-0306 1.35 µM 0.443813326029661 0.325291523542188 no 1086 0.328588776495176 1563 4686136 SGTC_161 4065-0411 162.148 µM 0.443670944790762 0.325342395518398 no 1087 0.328640252520199 1617 1906281 YLR208W SEC13 SGTC_2059 5238311 157 µM 0.442756508487811 0.325669195753974 no 1088 0.328970932159016 1535 703021 SGTC_488 nitrendipine 139 µM 0.442312387711461 0.325827963517283 no 1089 0.329131584014533 1611 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.441834311000227 0.3259989054205 no 1090 0.3293045540267 1596 17037758 SGTC_2991 9074669 71.4286 µM 0.441765543241149 0.326023497144503 no 1091 0.329329437476004 1656 17333109 SGTC_2007 4011539 71.82 µM 0.4415465275518 0.326101823386494 no 1092 0.329408692817138 1546 45595301 SGTC_105 0111-0055 734.78 µM 0.43972329228929 0.326754161707704 no 1093 0.330068765273924 1561 5179370 SGTC_2958 9077254 16.72 µM 0.438538574480337 0.327178328025544 no 1094 0.330497956822978 1559 16457351 SGTC_362 0310-0100 9.03 µM 0.437194630980914 0.327659772489236 no 1095 0.330985101572641 1571 790235 SGTC_2303 7774051 200 µM 0.436439242344242 0.327930503276138 no 1096 0.33125903614664 1641 2953184 SGTC_86 0417-1630 471.922 µM 0.435529556806096 0.328256654010573 no 1097 0.331589044912673 1586 3634867 SGTC_3314 9135860 59.4275 µM 0.434745860504464 0.328537738680635 no 1098 0.331873453134884 1636 25252478 SGTC_3325 9138760 55.175 µM 0.433242874157217 0.329077079187751 no 1099 0.332419167196016 1526 43844959 SGTC_2161 5662504 8.5105 µM 0.432788113855629 0.329240338267451 no 1100 0.332584354618187 1559 2859334 SGTC_1992 st073643 23.3 µM 0.43032042229425 0.330126807411801 no 1101 0.333481286679468 1587 3161292 SGTC_1925 st057770 10.1 µM 0.429982960740677 0.330248108068046 no 1102 0.333604018028517 1485 5989122 SGTC_2989 9073649 71.4286 µM 0.429178513654924 0.33053733875651 no 1103 0.333896659095693 1652 21367202 SGTC_2747 doxorubicin 7.63 µM 0.427176369013915 0.331257628542866 no 1104 0.3346254359416 1588 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_149 3970-0822 46.1 µM 0.426721020488749 0.331421531622729 no 1105 0.334791269061495 1608 3114250 YBL034C STU1 SGTC_2310 7668677 200 µM 0.426146949513361 0.331628214963616 no 1106 0.335000385563591 1626 2197143 SGTC_1570 verbenone 133 µM 0.424785578404508 0.332118555617397 no 1107 0.335496495859015 1706 29025 A natural terpanoid with antifungal properties. SGTC_336 4111-0029 111 µM 0.42439789037243 0.332258246312405 no 1108 0.335637829503256 1559 3131175 SGTC_543 3844-1095 191 µM 0.4237635296834 0.332486867691306 no 1109 0.335869139070556 1671 4230703 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.42324699524619 0.332673070944294 no 1110 0.336057531101851 1553 115019 SGTC_2409 alverine citrate 63.97 µM 0.422990041077745 0.332765714615497 no 1111 0.336151263562452 1725 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_495 decylubiquinone 155 µM 0.422688215239528 0.332874549608339 no 1112 0.336261377448278 1552 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2038 4100038 30.985 µM 0.421571866127634 0.333277214811775 no 1113 0.336668772540362 1625 3596803 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.419878507338398 0.3338883732574 no 1114 0.337287104714644 1662 804 An inhibitor of viral and cellular DNA polymerases. SGTC_636 0kpi-0074 126 µM 0.419745149638766 0.333936522788634 no 1115 0.337335819153384 1595 616434 SGTC_2368 9071271 200 µM 0.417144897682925 0.334875903588174 no 1116 0.338286213253592 1554 27209959 SGTC_3266 9136860 49.47 µM 0.416340267795878 0.335166798236432 no 1117 0.338580515314636 1575 4871271 YPR165W RHO1 SGTC_181 1447-1644 8.07 µM 0.415969416905755 0.335300903787842 no 1118 0.338716191235072 1682 534600 SGTC_576 1073-0113 22.7 µM 0.415223796655457 0.335570595387581 no 1119 0.338989039981862 1682 5439563 SGTC_508 roscovitine 141 µM 0.414199427092425 0.335941249046736 no 1120 0.339364030676727 1663 160355 A CDKinase inhibitor. SGTC_1132 3456-3614 2.5 µM 0.414093320020063 0.335979651521046 no 1121 0.339402882366006 1812 3125502 SGTC_1673 st016611 27.3 µM 0.413690184396459 0.33612557074423 no 1122 0.339550508257032 1690 5226799 SGTC_3284 9108171 64.8615 µM 0.411345705144448 0.336974668784107 no 1123 0.34040953008985 1620 8687505 SGTC_974 1326-0144 138 µM 0.411173778528527 0.337036968070038 no 1124 0.340472557008311 1585 5411856 SGTC_2443 5493264 126.67 µM 0.410316888097178 0.33734753730604 no 1125 0.34078675258131 1717 5340055 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.409749714466288 0.337553163289352 no 1126 0.340994778625795 1719 688664 SGTC_2227 7312221 64.1025 µM 0.409661798266024 0.337585041215381 no 1127 0.341027028564873 1652 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2284 7945075 39.21 µM 0.407246517325366 0.338461263802725 no 1128 0.34191346972992 1760 1245402 SGTC_219 mitoxanthrone 164.414 µM 0.407012158172631 0.338546331954384 no 1129 0.34199952924524 1683 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_664 1222-0054 14.9 µM 0.406568705979885 0.338707319654713 no 1130 0.34216239271365 1617 6813991 SGTC_1803 st050068 52.4 µM 0.405606354388713 0.339056786213032 no 1131 0.342515929575523 1638 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_922 1866-0035 480 µM 0.40551248139831 0.339090882495525 no 1132 0.342550422870217 1649 3156169 SGTC_1135 dihydrocapsaicin 536.708 nM 0.404198082223563 0.339568433161875 no 1133 0.343033531940172 1528 107982 A Capsaicinoid. SGTC_3051 9093778 49.47 µM 0.403810589253727 0.339709267256145 no 1134 0.343176004499662 1639 17217378 SGTC_2775 cyproheptadine 69.59 µM 0.403654793617666 0.339765897398558 no 1135 0.34323329338009 1645 2913 A selective serotonin reuptake inhibitor. SGTC_1092 toremifene 6.32 µM 0.403602724414428 0.339784824835237 no 1136 0.343252440973639 1625 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1035 k081-0041 55.2 µM 0.403315688458545 0.339889171206012 no 1137 0.343358000950034 1718 731709 SGTC_249 wiskostatin 11.211 µM 0.401373643982417 0.340595485876439 no 1138 0.344072525438739 1707 2775510 A n-wasp and actin depolymerizer. SGTC_3192 9110362 49.47 µM 0.40132943401784 0.340611571404311 no 1139 0.344088797834236 1659 16649480 SGTC_2812 7970281 58.44 µM 0.400830223997543 0.34079322605885 no 1140 0.344272562478764 1736 2233435 SGTC_1460 k062-0059 9.15 µM 0.400771062510388 0.340814756439189 no 1141 0.344294342904496 1566 1373085 SGTC_1134 3477-0009 42.5 µM 0.39973677499991 0.341191243874148 no 1142 0.344675201399746 1810 3973534 SGTC_1420 4'-methoxyflavone 42 µM 0.399223235802361 0.341378234288005 no 1143 0.34486436186564 1735 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1966 st070145 16.1 µM 0.399161787848409 0.341400611389254 no 1144 0.344886998615265 1583 3748532 SGTC_1047 2043-3044 82 µM 0.398953920447838 0.341476313239994 no 1145 0.344963578792388 1567 669592 SGTC_743 1275-0778 158 µM 0.398277446245529 0.341722718034478 no 1146 0.345212841784443 1731 2849257 YMR203W TOM40 SGTC_2272 7805186 180 µM 0.398209472584663 0.341747481077798 no 1147 0.345237892009958 1681 2956062 YPR165W RHO1 SGTC_2671 danthron 100 µM 0.396112886390318 0.342511608767306 no 1148 0.346010876118721 1623 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_942 3253-1115 227 µM 0.396083002959895 0.342522504835816 no 1149 0.346021898400455 1720 46497897 SGTC_1089 terbinafine 2.25 µM 0.395109385117094 0.342877576108634 no 1150 0.346381081443315 1707 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_134 0269-0018 6.916 µM 0.395050120234517 0.342899194061248 no 1151 0.346402949662244 1573 4378915 SGTC_2214 7179297 48.276 µM 0.394941698582187 0.342938744178144 no 1152 0.346442957620709 1685 769744 SGTC_964 1287-0107 19.4 µM 0.391389321666683 0.344235532150266 no 1153 0.347754742084253 1744 51516812 YPR165W RHO1 SGTC_1368 1852-0141 284 µM 0.390406286135738 0.344594711841691 no 1154 0.34811807013639 1646 2838987 SGTC_1763 st044482 94.5 µM 0.389948619905643 0.344761980911179 no 1155 0.348287270297636 1691 88505 SGTC_761 k216-0224 480 µM 0.388643010226399 0.345239325300622 no 1156 0.348770122780518 1820 1340404 SGTC_1844 rapamycin 4 nM 0.387575024896185 0.345629974964045 no 1157 0.349165277113635 1654 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_335 4077-0256 27.6 µM 0.3873821307078 0.345700549704273 no 1158 0.34923666537386 1730 3121989 SGTC_1660 st012960 28.1 µM 0.387216353220086 0.345761207465724 no 1159 0.349298022269801 1645 24207266 SGTC_843 0310-0051 143 µM 0.38609521049767 0.346171535958667 no 1160 0.349713078417795 1662 2065037 SGTC_3119 9125183 49.47 µM 0.384904725940588 0.346607440726148 no 1161 0.350154002185352 1688 22695334 SGTC_120 rhodamine 6G 52.259 µM 0.384220882657383 0.346857926942489 no 1162 0.350407370938075 1613 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3267 9137951 49.47 µM 0.384026070881198 0.346929297164067 no 1163 0.350479562262966 1685 16643986 SGTC_2452 5863136 48.41 µM 0.38342732481784 0.347148684622165 no 1164 0.350701473160462 1609 2184096 SGTC_1276 0871-0068 94.2 µM 0.383067886082492 0.347280411733241 no 1165 0.35083471500341 1732 3414906 SGTC_1316 1272-0050 65.9 µM 0.381125091297262 0.347992726206404 no 1166 0.351555214916971 1667 7340392 SGTC_1712 st032288 53.4 µM 0.380922596383465 0.348067000724642 no 1167 0.351630342415434 1629 2883011 SGTC_2872 9044037 25.97 µM 0.380916254678705 0.3480693269368 no 1168 0.35163269534055 1743 6465195 SGTC_1361 1608-0041 5.61 µM 0.378809715403254 0.348842346284614 no 1169 0.352414586142237 1628 X1361 SGTC_716 1683-5115 658 µM 0.378541196361219 0.348940927686715 no 1170 0.352514298113765 1702 723597 SGTC_651 3253-0966 34.4 µM 0.378327245622709 0.349019482725917 no 1171 0.352593753924713 1639 781462 SGTC_2751 anetholtrithion 17.25 µM 0.377939309564619 0.349161935436909 no 1172 0.352737839817713 1766 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1101 ebselen 5.29 µM 0.371249448581512 0.35162182559921 no 1173 0.355225872929549 1814 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_297 0986-0032 24 µM 0.370041946403786 0.352066495549531 no 1174 0.355675618258491 1663 2847425 SGTC_1161 k007-0610 110 µM 0.370041339399137 0.352066719133589 no 1175 0.355675844393569 1709 5843850 SGTC_1870 st057514 26.5 µM 0.369595001028597 0.352231137223702 no 1176 0.355842138186808 1654 5393161 SGTC_1461 k072-0203 53.8 µM 0.369295190385784 0.352341594266821 no 1177 0.355953855055102 1630 5418714 SGTC_3044 9093193 49.47 µM 0.368969470870463 0.352461610842809 no 1178 0.356075240229931 1624 25236277 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.368159293606383 0.352760197333056 no 1179 0.356377230458011 1700 616764 SGTC_68 0986-0284 82.829 µM 0.367605858085192 0.352964215193773 no 1180 0.35658357306199 1579 423278 YIL048W NEO1 SGTC_1597 7-benzyloxygramine 47.5 µM 0.366343287757265 0.353429805901004 no 1181 0.357054466162589 1645 260807 SGTC_921 1561-0023 372 µM 0.36343637523282 0.354502604257588 no 1182 0.358139466607224 1630 24050882 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.362508773869024 0.354845179829647 no 1183 0.358485934088935 1665 75037 A free radical scavenger. SGTC_2388 9080168 200 µM 0.362447138335094 0.35486794681816 no 1184 0.35850895964854 1605 15943073 SGTC_318 1488-0629 67.2 µM 0.361599824632863 0.35518098081605 no 1185 0.35882554786728 1653 3662576 SGTC_897 1000-0139 31.4 µM 0.36156202249035 0.35519494882717 no 1186 0.358839674429434 1796 6151020 SGTC_2773 thioridazine 9.09 µM 0.360156068242288 0.355714591408262 no 1187 0.359365212850603 1715 5452 An antipsychotic. SGTC_2975 9084847 53.72 µM 0.359865109627357 0.35582216363581 no 1188 0.359474004947392 1668 27211724 SGTC_2924 9010168 62.78 µM 0.35981871687906 0.355839316866105 no 1189 0.359491352675027 1679 2993929 SGTC_763 3453-1109 128 µM 0.35979418988636 0.355848385581399 no 1190 0.359500524216565 1806 1560353 SGTC_2145 5634607 200 µM 0.357979778151671 0.356519479854117 no 1191 0.360179223396002 1638 308662 SGTC_1790 st045711 43.5 µM 0.354822344375912 0.357688374823885 no 1192 0.36136134388144 1810 585119 SGTC_2028 5153890 36.43 µM 0.352396742870511 0.358587250552275 no 1193 0.362270372169534 1680 2830968 YPR165W RHO1 SGTC_85 0868-0259 160.055 µM 0.350651869451328 0.359234348241736 no 1194 0.362924769024671 1725 83173 SGTC_248 streptozotocin 5.23457 mM 0.350304440271252 0.35936324290891 no 1195 0.363055116639207 1793 5300 DNA alkylating agent. SGTC_2458 5808907 16.39 µM 0.350152022267588 0.359419794356419 no 1196 0.363112305453761 1816 2731747 SGTC_889 0919-1524 82.7 µM 0.350025583086917 0.359466709252913 no 1197 0.36315974906095 1677 3905452 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.349608281839477 0.359621562717924 no 1198 0.363316347355689 1813 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3297 9117502 71.43 µM 0.349223789187575 0.359764261871401 no 1199 0.363460653977861 1726 7453720 SGTC_672 1441-0018 53.7 µM 0.347748366910193 0.3603120258419 no 1200 0.364014584701509 1656 251141 SGTC_619 1652-1634 108 µM 0.347724103454794 0.360321036271408 no 1201 0.364023696522199 1689 5400454 SGTC_3141 9094609 49.47 µM 0.347419266385178 0.360434246580137 no 1202 0.36413818061218 1638 25236309 YDL196W YDL196W SGTC_2204 7233102 200 µM 0.34556052701129 0.361124809156014 no 1203 0.364836507627811 1764 2172480 SGTC_1197 1601-0112 267 µM 0.344340602895948 0.361578284101195 no 1204 0.36529507622894 1661 7350313 SGTC_207 4185-0010 4.486 µM 0.343212124182268 0.361997939800905 no 1205 0.365719442130954 1777 3761753 SGTC_1147 3809-1045 12.3 µM 0.343084533367765 0.362045398390448 no 1206 0.36576743317735 1695 325925 SGTC_2433 5607874 27.82 µM 0.342426691370342 0.362290122483275 no 1207 0.366014902227174 1663 2252428 SGTC_2716 st080858 38.6235 µM 0.342374945261063 0.362309374965743 no 1208 0.366034370606041 1787 5296050 SGTC_1514 1189-1591 158 µM 0.341625379844014 0.362588294779816 no 1209 0.36631641739774 1790 767698 YMR146C TIF34 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.340855358039819 0.362874902548615 no 1210 0.366606236743105 1829 5357218 A potent inhibitor of glutathione S-transferases. SGTC_328 k915-0120 63.5 µM 0.340692035417507 0.362935702308984 no 1211 0.36666771758622 1822 6624543 SGTC_2843 9000894 45.46 µM 0.339656701461471 0.363321204162149 no 1212 0.367057536163068 1680 2242070 SGTC_788 1182-0090 188 µM 0.338591063528742 0.363718134183241 no 1213 0.367458907817764 1867 5715185 SGTC_642 0335-0876 158 µM 0.338538365111003 0.363737767149508 no 1214 0.367478760395609 1724 6812350 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.337169837064704 0.364247741859754 no 1215 0.367994436943272 1806 1241132 A phosphatase inhibitor. SGTC_1028 k015-0029 4.8 µM 0.336492647509296 0.364500181937067 no 1216 0.368249697555986 1680 4588309 SGTC_1209 2323-2347 50.3 µM 0.335985207603874 0.364689381932851 no 1217 0.368441010672647 1835 5412760 SGTC_2338 7999974 200 µM 0.33581037115559 0.364754577693536 no 1218 0.368506934421842 1902 315925 SGTC_349 k015-0014 24 µM 0.334221925873908 0.365347081094358 no 1219 0.369106049963341 1680 2196908 SGTC_1777 st045864 34.765 µM 0.334075280932149 0.365401797119243 no 1220 0.369161376249019 1725 4691462 SGTC_553 k007-0256 45.7 µM 0.333304212201553 0.365689542618698 no 1221 0.369452330061807 1752 6287000 SGTC_3302 9125395 16.351 µM 0.332892580500055 0.365843185265195 no 1222 0.369607685122417 1742 17599668 SGTC_1871 st057448 67.3 µM 0.332752547978229 0.365895457689802 no 1223 0.369660540038674 1823 691747 SGTC_2931 9014674 55.67 µM 0.331850017095267 0.366232421103732 no 1224 0.370001257056968 1671 2996810 SGTC_1657 st012939 43.4 µM 0.329746788726974 0.367018069572013 no 1225 0.370795648445493 1826 24207257 SGTC_3253 9135987 49.47 µM 0.328983862741672 0.367303193947392 no 1226 0.37108394270935 1773 4182430 SGTC_64 000l-0018 272.079 µM 0.327526002575587 0.367848235895339 no 1227 0.371635039654291 1706 6811119 SGTC_1048 3161-0300 24.5 µM 0.326583268785949 0.368200832259331 no 1228 0.371991549910137 1704 2165101 SGTC_1568 digitonin 820 nM 0.326453609363199 0.368249335492233 no 1229 0.372040591342946 1906 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2032 5185112 25.99 µM 0.32576203688412 0.368508075638297 no 1230 0.372302201711184 1776 5718189 SGTC_1744 st037937 38.9 µM 0.325033753253813 0.368780615105137 no 1231 0.372577763016141 1790 1016152 SGTC_2026 5148700 152 µM 0.324831262358878 0.36885640330523 no 1232 0.372654391267099 1724 79838 SGTC_2904 7225135 42.03 µM 0.324704468407384 0.368903862284479 no 1233 0.372702376231621 1831 4446116 SGTC_3006 9075424 71.4286 µM 0.319047773432625 0.371023187401305 no 1234 0.374845143153424 1696 7465181 SGTC_2987 9018338 71.43 µM 0.31758386716561 0.371572292132911 no 1235 0.375400306602391 1747 5055682 SGTC_206 4546-0025 72.014 µM 0.317243207780712 0.371700109491066 no 1236 0.37552953338846 1775 6620745 YIL048W NEO1 SGTC_1818 st052136 56.3 µM 0.31667773508979 0.371912309314266 no 1237 0.375744072377097 1697 674169 SGTC_717 1532-0246 73.2 µM 0.316057981421907 0.372144923364747 no 1238 0.375979249567266 1741 9561992 SGTC_1471 k673-0312 37 µM 0.314698889367631 0.372655198836347 no 1239 0.376495143799078 1858 24099884 SGTC_137 0438-0332 85.389 µM 0.313809001584663 0.372989431240357 no 1240 0.376833053611984 1774 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1885 st057546 99.9 µM 0.312647055588979 0.373425989730928 no 1241 0.37727441189473 1851 702008 SGTC_3202 9113761 49.47 µM 0.312384254233571 0.373524750231908 no 1242 0.377374257684265 1905 4798415 SGTC_1891 st059073 26.2 µM 0.311925320537332 0.373697236998006 no 1243 0.377548639441016 1901 688754 SGTC_1484 3473-2379 286 µM 0.311849793202544 0.373725625802229 no 1244 0.377577340074164 1797 671917 SGTC_1548 st061468 90.8 µM 0.307852217717363 0.375229187024024 no 1245 0.379097392903987 1869 390799 SGTC_2801 7907800 81.82 µM 0.306570731575968 0.375711580169646 no 1246 0.379585067167966 1737 6620925 SGTC_534 k292-0788 63.4 µM 0.30601181395072 0.375922035888166 no 1247 0.3797978253839 1939 4146317 SGTC_365 0121-0052 13.6 µM 0.305680383474254 0.376046850677038 no 1248 0.379924005276546 1812 3101739 SGTC_1718 roemerine 11.9335 µM 0.305390729714111 0.376155943216745 no 1249 0.380034290698975 1780 235224 An aporphine alkaloid with mutagenic activity. SGTC_901 1112-0062 60.1 µM 0.305054644556366 0.376282535655331 no 1250 0.38016226706311 1767 1908457 SGTC_2124 5246320 200 µM 0.303259184337996 0.376959052794091 no 1251 0.38084617429855 1800 579342 SGTC_740 k014-0057 261 µM 0.302640197362897 0.377192370563537 no 1252 0.381082038547998 1881 4012779 SGTC_3309 9129340 25.759 µM 0.299741443911333 0.37828560720059 no 1253 0.382187191776316 1820 17158987 SGTC_1675 st018485 24.5 µM 0.298778152645967 0.378649119416442 no 1254 0.382554660805391 1764 3323024 SGTC_466 geldanamycin 89.2 µM 0.298610913718323 0.378712240450702 no 1255 0.382618468625051 1906 5288382 HSP90 inhibitor. SGTC_1288 0973-0013 65.5 µM 0.298522377020232 0.378745658190859 no 1256 0.382652249931282 1808 4315430 SGTC_3294 9122953 26.2835 µM 0.298181065589028 0.37887449298948 no 1257 0.382782486158778 1738 16459826 SGTC_1893 st059353 36.1 µM 0.297603012842933 0.379092721207137 no 1258 0.383003087401753 1755 3112488 SGTC_1616 st002734 56.1 µM 0.297047177596277 0.37930259815614 no 1259 0.383215245613955 1819 4026101 SGTC_1867 st057372 64 µM 0.296674798859281 0.379443223958056 no 1260 0.383357399430281 1798 688837 SGTC_2594 a-mangostin 100 µM 0.295604573808837 0.379847474484046 no 1261 0.383766040135741 1900 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_486 niguldipine 82 µM 0.295549751089967 0.379868185923545 no 1262 0.383786976409124 1833 1236 A calcium channel blocker. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.294799948432518 0.380151487946327 no 1263 0.384073352914652 1789 5379071 SGTC_2560 caryophyllene 100 µM 0.293345525087842 0.380701203889771 no 1264 0.384629029683046 1770 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_516 3992-2719 87.3 µM 0.293326740019653 0.380708305499617 no 1265 0.384636208256876 1668 5350887 YDR037W KRS1 SGTC_3122 9126309 49.47 µM 0.292447014447941 0.381040926740864 no 1266 0.384972433090676 1930 17591206 SGTC_1167 k781-0610 148 µM 0.29215419120562 0.381151661725418 no 1267 0.385084367246139 1787 4525169 SGTC_943 3253-1379 105 µM 0.291122151405295 0.381542018776279 no 1268 0.385478949462954 1868 668464 SGTC_222 nsc-310342 10.666 µM 0.289812305607663 0.382037626219652 no 1269 0.38597991659461 1901 432556 SGTC_2683 piperine 63.03 µM 0.287925223323714 0.382751982903423 no 1270 0.38670198934734 1820 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2673 kobusone 100 µM 0.287253793893808 0.383006249493491 no 1271 0.386958999735276 1844 6710676 An epoxy ketone and protein crosslinker. SGTC_1958 st076513 41.9 µM 0.286758606860191 0.383193806379843 no 1272 0.387148579662432 1776 732122 YGL099W LSG1 SGTC_390 dec-rvkr-cmk 16.7 µM 0.286754821363639 0.383195240278858 no 1273 0.387150029024966 1832 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1683 st010134 710 nM 0.286715962771987 0.383209959522626 no 1274 0.387164907002115 1722 3818134 SGTC_2865 9030313 51.95 µM 0.286662284284893 0.383230292671081 no 1275 0.387185459417035 1724 42562754 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.285628087880937 0.383622103952791 no 1276 0.38758149413338 1831 4000243 SGTC_1195 1502-0147 41.1 µM 0.285200258078094 0.383784224572458 no 1277 0.387745361325287 1786 817940 SGTC_327 1273-0057 3.96 µM 0.285060718988549 0.38383710552273 no 1278 0.387798811854692 1859 3108138 SGTC_2515 chrysin 20.77 µM 0.283446798294885 0.38444888794604 no 1279 0.38841717937793 1887 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_178 4092-0806 87.505 µM 0.28111388677505 0.385333723888885 no 1280 0.389311525183955 1821 2169044 SGTC_2418 pentamidine 31.67 µM 0.281008241217088 0.385373807725289 no 1281 0.389352039423412 1899 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1574 spiramycin 23.7 µM 0.279904368509164 0.385792710172585 no 1282 0.389775437776916 1790 6419898 An antibiotic and protein synthesis inhibitor. SGTC_113 0099-0221 2.5 µM 0.278772721967844 0.386222290652589 no 1283 0.390209624801513 1915 89219 SGTC_1208 2323-2347 50.3 µM 0.277940218096385 0.386538403707689 no 1284 0.390529125081515 1948 5412760 SGTC_16 erodoxin 22.806 µM 0.277879077629648 0.386561622546364 no 1285 0.39055259262952 1853 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2361 9034121 116 µM 0.277727975432896 0.386619007192248 no 1286 0.390610591902394 1799 6496917 SGTC_1838 st055369 84.5 µM 0.277398541543767 0.386744126124951 no 1287 0.390737050691242 1812 676036 SGTC_2313 7726885 200 µM 0.275200981962981 0.387579059472027 no 1288 0.391580916294392 1819 726423 SGTC_2971 9092186 9.93 µM 0.275138107788687 0.3876029553453 no 1289 0.391605067585078 1675 25236400 SGTC_735 3076-0345 636 µM 0.270646794361976 0.389311014113131 no 1290 0.393331350901773 1920 2888990 SGTC_2337 9009472 200 µM 0.269796827095602 0.389634500903986 no 1291 0.393658281975179 1927 5742383 SGTC_835 0312-0010 67.2 µM 0.26932633745723 0.389813596206812 no 1292 0.393839283176997 1824 1626196 SGTC_654 1124-0271 80.9 µM 0.266144148582768 0.391025532027193 no 1293 0.395064097525464 1767 5403748 SGTC_2274 7947094 46.08 µM 0.263653459276472 0.39197484992851 no 1294 0.396023480477278 1915 2971028 SGTC_879 0831-1030 162 µM 0.263496334111067 0.392034759294777 no 1295 0.396084024353099 1801 1549252 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.263178973807078 0.392155771616192 no 1296 0.396206318090798 1999 551469 SGTC_2646 retinol 96.75 µM 0.26075979452528 0.39307856832386 no 1297 0.397138875656656 1876 445354 A vitamin A analog and teratogen. SGTC_1555 citronellol 128 µM 0.260484843407074 0.393183486655719 no 1298 0.397244902552592 1980 8842 A terpine precursor. SGTC_1782 st039423 80.636 µM 0.260050861479522 0.393349105185959 no 1299 0.397412270501167 1788 2068169 SGTC_333 3486-0131 40.1 µM 0.258172327005452 0.394066223903532 no 1300 0.39813695699371 1975 6744690 SGTC_2241 6772625 37.8075 µM 0.25744075561398 0.394345594024905 no 1301 0.398419272186388 1937 2285411 SGTC_808 0711-0032 135 µM 0.256257117115058 0.394797713140974 no 1302 0.398876153738332 1980 4252555 SGTC_3196 9111891 49.47 µM 0.255606416063134 0.395046324424184 no 1303 0.399127381825128 1898 18891510 SGTC_3338 9144300 39.5675 µM 0.254875619477324 0.395325588498142 no 1304 0.399409583679368 1912 4901274 SGTC_2837 9008476 45.46 µM 0.254472197113222 0.395479773963464 no 1305 0.399565390377392 1882 2992805 SGTC_2127 5253358 187.912 µM 0.253989032975449 0.395664457758879 no 1306 0.399752015382003 1804 20612 SGTC_1661 st013063 9.66 µM 0.252405066732651 0.396270074280817 no 1307 0.400363992110656 1847 721395 SGTC_683 panaxydol 45 µM 0.252205568389003 0.396346368623663 no 1308 0.400441087109481 1949 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2363 9053361 176 µM 0.250084380670446 0.397157821413871 no 1309 0.401261047346316 1965 6469797 YMR079W SEC14 SGTC_2175 5807670 165.306 µM 0.250004983952926 0.397188203013833 no 1310 0.401291747182585 1970 241186 SGTC_3150 9097574 49.47 µM 0.248356135633286 0.397819284833457 no 1311 0.401929434598739 1981 17217476 SGTC_2546 rhodinyl acetate 100 µM 0.244910331789653 0.399138996928612 no 1312 0.403262930831742 1999 6708682 SGTC_539 4859-0462 2.54 µM 0.244755384305428 0.39919836764716 no 1313 0.403322920727843 2008 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1921 5740136 50 µM 0.24473341972944 0.399206783930315 no 1314 0.403331424777913 2005 1774243 SGTC_3054 9094397 49.47 µM 0.244134428454388 0.399436320643934 no 1315 0.403563354525404 1826 2598354 SGTC_3091 9116372 49.47 µM 0.243701794101307 0.399602130109103 no 1316 0.403730891883206 1905 17169793 SGTC_2480 5767542 37.17 µM 0.242817227948632 0.399941201222779 no 1317 0.40407349447232 1912 2867358 SGTC_982 1491-0518 27.5 µM 0.240522258486529 0.40082125812009 no 1318 0.404962704930982 1881 3091256 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.240243262113127 0.400928279882712 no 1319 0.405070838618735 1876 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_19 0279-0214 38.434 µM 0.236121862985993 0.40251009228152 no 1320 0.406669054658938 1906 3566274 YBR002C RER2 SGTC_364 0083-0097 67.7 µM 0.235856460781594 0.402612009921374 no 1321 0.406772027209114 1868 5207356 SGTC_3247 9135149 49.47 µM 0.235845922508999 0.402616056881522 no 1322 0.406776116052805 1910 8934436 YOR116C RPO31 SGTC_1245 0418-0076 17.2 µM 0.230396969867826 0.404709979024404 no 1323 0.408891657761696 1915 6790114 SGTC_1709 st033179 39.1045 µM 0.229261850053521 0.405146528386791 no 1324 0.409332701532794 1899 573381 SGTC_1615 st002656 86.5 µM 0.226370479575321 0.406259036461247 no 1325 0.410456642958435 1896 1584458 SGTC_962 1254-0300 21.5 µM 0.225989315546135 0.406405753031515 no 1326 0.41060486517238 1901 7340576 SGTC_1005 4092-0690 4.4 µM 0.225716009667581 0.406510961241097 no 1327 0.410711152743248 1863 1529343 SGTC_584 0986-0246 15.4 µM 0.225592901558374 0.406558353512761 no 1328 0.410759031140483 2018 53315 YDR232W HEM1 SGTC_833 3852-0053 558 µM 0.225434759331833 0.406619234689882 no 1329 0.410820536727596 1945 3123681 SGTC_2822 7994718 71.43 µM 0.224295337715942 0.407057952850031 no 1330 0.411263751882253 1966 1018011 SGTC_1715 st032160 10.2275 µM 0.223231221111491 0.40746778122922 no 1331 0.411677777012854 1988 5289825 SGTC_2146 5545642 200 µM 0.222705740920474 0.407670199351045 no 1332 0.411882266481932 2000 825326 SGTC_2376 9072922 81.32 µM 0.222192141708034 0.407868064671183 no 1333 0.412082155621272 1955 17087968 SGTC_1819 st053448 58.6 µM 0.22109466755021 0.408290947905917 no 1334 0.412509361102408 1938 2857616 SGTC_312 4092-0653 6.84 µM 0.220148578757957 0.40865558447393 no 1335 0.412877721170754 2004 1148278 SGTC_2828 7998861 71.43 µM 0.219761069075211 0.408804959266816 no 1336 0.413028620396488 2035 2988188 SGTC_1171 0368-0077 21.4 µM 0.219260875219434 0.408997790428075 no 1337 0.413223418695317 1898 3239779 SGTC_3079 9117512 49.47 µM 0.21864875768171 0.409233799574475 no 1338 0.413461834246679 1962 7185044 SGTC_514 4466-0038 2.65 nM 0.218068311267011 0.409457627941826 no 1339 0.413687943593248 1933 5722064 SGTC_2771 fluoxetine 41.05 µM 0.217723306554776 0.409590680641401 no 1340 0.413822351633002 1989 3386 A selective serotonin reuptake inhibitor. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.215705939574406 0.410368895754135 no 1341 0.414608485550434 1945 521171 SGTC_1785 bathophenanthroline 24 µM 0.214947387338863 0.410661604723454 no 1342 0.414904169256155 1858 72812 An iron chelator. SGTC_848 0368-0089 85.6 µM 0.214502374365557 0.410833348816016 no 1343 0.415077657789493 2030 762535 SGTC_1326 1431-2094 10.8 µM 0.212863735238266 0.411465896811111 no 1344 0.415716624599162 1861 616278 SGTC_968 1309-0633 340 µM 0.210724175536876 0.412292156605985 no 1345 0.416551254408702 2051 3761976 SGTC_1637 st007924 17.4 µM 0.210172087190408 0.412505426547676 no 1346 0.416766682103029 1905 683336 SGTC_1469 k284-2957 126 µM 0.209824728576131 0.412639623301224 no 1347 0.416902236025525 1981 23884841 SGTC_2799 7812892 81.82 µM 0.208839336400176 0.413020370208207 no 1348 0.417286831162347 2020 20205235 SGTC_3355 9151058 44.0485 µM 0.208468604164689 0.413163639101902 no 1349 0.417431547174697 2047 17015728 SGTC_1682 st012968 530 nM 0.207866958816296 0.413396168612934 no 1350 0.417666424342942 1857 24207270 SGTC_1620 st003704 16.5 µM 0.206702724095644 0.413846219119368 no 1351 0.418121014913084 2045 2834414 SGTC_1680 diphenhydramine 100 µM 0.206640949212144 0.41387010219424 no 1352 0.418145138780716 1902 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2052 5265182 7.135 µM 0.206599382760369 0.413886172572689 no 1353 0.418161371175352 2018 1239884 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.206313432617468 0.413996730227304 no 1354 0.418273043265392 2000 688761 SGTC_3322 9139058 2.11 µM 0.205292176359603 0.414391636801465 no 1355 0.418671928124595 2007 4908926 YPR165W RHO1 SGTC_789 1309-1135 70.6 µM 0.204492141317526 0.414701060479196 no 1356 0.418984466284111 2001 3092424 SGTC_1138 3761-0006 1.03 µM 0.203460730382963 0.415100049796534 no 1357 0.419387468159036 2042 12061087 SGTC_2840 9008771 71.43 µM 0.20256114019244 0.415448117313064 no 1358 0.419739032953154 2067 2992978 SGTC_2694 st077685 81.9 µM 0.199858194398346 0.416494333505148 no 1359 0.420795743391551 1910 2838096 SGTC_2679 rapamycin 1 nM 0.199366380448006 0.416684761417668 no 1360 0.420988078540884 1973 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_529 4076-0302 30.3 µM 0.198206647237885 0.417133881680246 no 1361 0.421441693459074 1922 5816522 SGTC_2218 6965428 192.983 µM 0.195552756472428 0.418162037965674 no 1362 0.422480120546968 2035 675684 SGTC_2033 5192550 145 µM 0.194518677599081 0.418562807184549 no 1363 0.42288488621025 1926 182073 SGTC_3285 9112818 20.8695 µM 0.193800773755569 0.418841088864899 no 1364 0.423165940565024 2011 17017947 YPR165W RHO1 SGTC_192 3455-0609 60.9 µM 0.193271041556199 0.419046455459511 no 1365 0.423373352113504 1992 3769639 SGTC_840 0245-0196 390 µM 0.193168260517862 0.419086304172465 no 1366 0.423413597502316 2052 3827528 SGTC_301 4119-0100 24.5 µM 0.192375213781509 0.419393800165037 no 1367 0.423724153156635 1947 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3240 9133527 49.47 µM 0.191795795489692 0.419618494988198 no 1368 0.423951082268888 1968 17617455 SGTC_91 0417-1751 58.384 µM 0.19141326193994 0.419766853497268 no 1369 0.42410091531891 2097 6795624 SGTC_2759 disulfiram 3.38 µM 0.190892319418207 0.419968909682724 no 1370 0.42430497887074 1943 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2006 4011487 200 µM 0.190623290400215 0.420073265307553 no 1371 0.424410370840101 2042 45595294 SGTC_1710 st031758 61.5 µM 0.189713585589597 0.420426178917062 no 1372 0.424766787193359 2076 5394341 SGTC_2626 ethyl orsellinate 100 µM 0.189120818692739 0.420656173126471 no 1373 0.424999062479135 1960 75653 A natural product. SGTC_2287 7945887 168.79 µM 0.187802453024693 0.421167797466388 no 1374 0.425515756374751 2084 1245853 SGTC_2629 bisabolol 100 µM 0.18662774190304 0.421623785318311 no 1375 0.425976256997207 2010 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2512 diallyl trisulfide 49.23 µM 0.186053560420332 0.421846703744293 no 1376 0.426201379689511 2095 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_677 0929-0063 136 µM 0.185507150867941 0.422058863340803 no 1377 0.42641563601374 2065 1539583 SGTC_1640 st009078 66.4 µM 0.184996495483973 0.422257160778721 no 1378 0.426615892165252 2064 690618 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.184422663130212 0.422480014579276 no 1379 0.426840946064615 2056 88881 An O-methylated flavonoid and antioxidant. SGTC_402 epigallocatechin gallate 10 µM 0.183850315268584 0.422702316582478 no 1380 0.427065441480222 1935 65064 An antioxidant. SGTC_332 4112-0506 40.9 µM 0.182931165018049 0.4230593693889 no 1381 0.427426014667985 1979 2790355 SGTC_1257 0669-0121 16 µM 0.182281108275955 0.423311928395294 no 1382 0.427681061862309 2063 4307855 SGTC_227 fluconazole 33.516 µM 0.182268132784829 0.423316969933507 no 1383 0.427686153052987 1948 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_768 0384-0033 77.3 µM 0.181889933070585 0.423463922355275 no 1384 0.427834552480734 1903 3965305 YMR134W ERG29 SGTC_3121 9125696 49.47 µM 0.181679094080663 0.423545850097552 no 1385 0.427917286710691 2128 1235365 SGTC_2153 5569715 200 µM 0.177517561369786 0.425163609116932 no 1386 0.429550936155471 2040 2054701 SGTC_1766 st045414 44.774 µM 0.176780883361069 0.425450118318996 no 1387 0.429840252707258 2035 253960 SGTC_1831 st055328 12 µM 0.175838829478886 0.425816559761357 no 1388 0.430210281685055 2088 1103068 SGTC_726 3448-4391 34.2 µM 0.174626729425501 0.426288138359424 no 1389 0.43068647212564 2052 1356692 SGTC_1737 st035557 69.7 µM 0.17365337437054 0.426666907383328 no 1390 0.431068941266593 2057 5716916 SGTC_276 colchicine 750 µM 0.173462432001747 0.426741218179836 no 1391 0.431143977562424 2015 2833 A microtubule depolymerizer. SGTC_2853 9015042 58.44 µM 0.172173042100639 0.427243089835308 no 1392 0.431650745334329 2019 6457456 SGTC_311 1315-0136 58 µM 0.171786684357838 0.42739349555574 no 1393 0.431802617121457 2087 6759207 SGTC_2159 5658611 73.75 µM 0.170674841350526 0.427826385212559 no 1394 0.432239723115111 2106 793844 SGTC_3210 9128157 49.47 µM 0.17024063781953 0.427995463471573 no 1395 0.432410446895017 1842 17590849 SGTC_254 nsc-64875 3.808 µM 0.169646261964428 0.428226934044596 no 1396 0.432644169026246 2106 56993 SGTC_538 2922-0838 53.3 µM 0.167410610021528 0.42909779496103 no 1397 0.433523488698834 2126 777039 SGTC_339 3091-4833 71.4 µM 0.167377580997286 0.429110663464692 no 1398 0.433536482049931 2030 3240077 SGTC_3096 9117468 49.47 µM 0.16718312365466 0.429186427902908 no 1399 0.433612981452253 2107 41316311 SGTC_3042 9091578 49.47 µM 0.166070906220815 0.429619819930388 no 1400 0.434050574833275 2115 25236497 SGTC_2029 5175081 200 µM 0.165660249781974 0.429779859777035 no 1401 0.434212164906264 2090 1380876 SGTC_2871 9038510 12.99 µM 0.164921796752657 0.430067676583786 no 1402 0.434502767995213 2144 4945164 SGTC_2838 9002687 71.43 µM 0.164265521875629 0.430323495124078 no 1403 0.434761061262435 1914 6457060 SGTC_569 4130-2812 160 µM 0.163597602065312 0.430583882935942 no 1404 0.435023966273452 2148 743552 SGTC_2792 7535235 81.82 µM 0.162562795144667 0.430987360857305 no 1405 0.435431341211862 1954 1281891 SGTC_1470 k295-0292 231 µM 0.162047990808682 0.431188113262561 no 1406 0.435634031032653 2090 5045612 SGTC_41 0478-0632 82.643 µM 0.16049189387527 0.431795034606696 no 1407 0.43624680330548 2169 3750424 SGTC_3168 9103419 49.47 µM 0.160413763380384 0.431825511943227 no 1408 0.436277574202815 2127 16649256 SGTC_2732 terfenadine 20 µM 0.160291912970995 0.431873044461904 no 1409 0.436325564511574 2136 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1437 4092-1038 11.6 µM 0.160085913371369 0.431953404906801 no 1410 0.436406698782365 2039 3977136 SGTC_2661 dactinomycin 12.96 µM 0.159107161504528 0.432335254429776 no 1411 0.4367922230165 2102 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_537 1334-0398 209 µM 0.15858850202675 0.432537629497977 no 1412 0.43699654409989 2143 5846986 SGTC_899 1083-0020 478 µM 0.157873168694829 0.432816773509732 no 1413 0.437278370584829 2102 767123 SGTC_923 1900-2434 73.3 µM 0.156155930614763 0.433487026692956 no 1414 0.437955056395317 2078 5910570 SGTC_3273 9137859 49.47 µM 0.155118549735071 0.433892018437608 no 1415 0.438363929307066 2169 2377234 SGTC_1362 1611-0397 101 µM 0.154819405955033 0.434008816576373 no 1416 0.43848184596646 2041 27816 SGTC_2081 5214970 32.255 µM 0.154496898365756 0.434134743369268 no 1417 0.438608978302392 2132 2063512 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.153394664210699 0.434565173741303 no 1418 0.439043526217316 2089 16725076 SGTC_2889 9059656 51.95 µM 0.152252523013592 0.435011269934372 no 1419 0.439493884707786 2076 3949838 SGTC_1124 fisetin 1.16336 µM 0.152014394083079 0.43510428849971 no 1420 0.439587791378257 1965 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3345 9148410 3.559 µM 0.150423568433106 0.435725793001965 no 1421 0.440215223950578 2136 4903596 SGTC_2459 5811157 9.22 µM 0.149799162872539 0.435969779530746 no 1422 0.440461534918265 2160 2870684 YBR192W RIM2 SGTC_1501 4491-0275 38.4 µM 0.14913077760383 0.436230978137503 no 1423 0.44072522021039 2163 5104718 SGTC_2585 alliin 100 µM 0.148379989528476 0.436524412138865 no 1424 0.441021445649709 2080 87310 A garlic compound which reacts with lipids. SGTC_1778 st046819 58.9 µM 0.147456629028761 0.436885341309637 no 1425 0.441385805234782 2016 671715 SGTC_200 k038-0079 37.545 µM 0.147409929576497 0.436903596894335 no 1426 0.44140423423673 2089 3436683 SGTC_940 3232-1287 54.8 µM 0.146208691902037 0.437373226548207 no 1427 0.441878322076617 2184 1585493 YIL048W NEO1 SGTC_141 0443-0274 32.331 µM 0.143922696589384 0.438267190660292 no 1428 0.442780756493875 2156 1627241 SGTC_3151 9099821 49.47 µM 0.143646440359708 0.438375245188826 no 1429 0.442889833407836 2046 17174189 SGTC_363 0455-0021 3.06 µM 0.143518516914718 0.438425282567536 no 1430 0.442940344123292 2081 4597466 SGTC_2540 epiandrosterone 100 µM 0.139858033215888 0.439857498277384 no 1431 0.44438607997646 2204 441302 A steroid. SGTC_3235 9132602 49.47 µM 0.139511797374039 0.439993008972921 no 1432 0.444522867074862 2095 4912240 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.139353604097929 0.44005492541456 no 1433 0.444585366557488 2058 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2925 9010536 32.5 µM 0.139332941510426 0.440063012806477 no 1434 0.444593530097427 2069 2994177 SGTC_2431 5490079 200 µM 0.138911936696568 0.440227800655766 no 1435 0.44475986915171 2049 5722345 SGTC_397 arbidol 50 µM 0.138074358503759 0.440555672583774 no 1436 0.445090825300647 2140 131410 A RNA synthesis inhibitor. SGTC_2513 baicalein 25.65 µM 0.136083966433077 0.44133497928854 no 1437 0.445877451270828 2031 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1912 st060209 90.8 µM 0.135590945201638 0.441528049219991 no 1438 0.446072332012162 2029 688787 SGTC_2842 9000675 19.48 µM 0.135305125758895 0.441639984112424 no 1439 0.446185316289527 1955 2989072 SGTC_900 1112-0045 141 µM 0.13523121128616 0.441668931847339 no 1440 0.446214535353698 2166 56211 YIL048W NEO1 SGTC_977 1348-1378 135 µM 0.134883387718676 0.441805157041579 no 1441 0.446352037095681 2167 X977 SGTC_1144 3486-0183 12.5 µM 0.133201587024533 0.442463931557664 no 1442 0.447016977884277 2077 6744069 SGTC_2798 7813637 45.45 µM 0.132951392984545 0.442561948165717 no 1443 0.447115910954673 2104 956368 SGTC_3206 9114350 49.47 µM 0.132916563804499 0.44257559320648 no 1444 0.447129683557107 2185 17087243 SGTC_780 0109-0199 192 µM 0.13230437838558 0.442815440421423 no 1445 0.447371772185381 2184 610414 SGTC_3152 9099253 49.47 µM 0.131995377758897 0.442936511282005 no 1446 0.447493973887151 2125 25236131 SGTC_685 1278-0033 54.9 µM 0.131920441134937 0.442965873325197 no 1447 0.447523610122033 2144 3590572 SGTC_2567 aureobasidin a 60 nM 0.131493473708774 0.443133175811581 no 1448 0.447692474487756 2060 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2202 7226349 200 µM 0.131423504310201 0.44316059351795 no 1449 0.447720148084781 2148 844334 SGTC_356 1634-0012 32.5 µM 0.130824510917841 0.443395321894015 no 1450 0.44795706636355 2202 735457 SGTC_721 1187-1332 279 µM 0.130289489682277 0.443604998209298 no 1451 0.448168697604083 2128 25730 SGTC_3046 9092212 49.47 µM 0.130190538613489 0.443643779141208 no 1452 0.448207839981796 2155 25236637 SGTC_1383 3049-0032 20.7 µM 0.129827808166224 0.443785945177399 no 1453 0.44835133068653 2161 712864 SGTC_628 1636-0253 16 µM 0.129004325585422 0.444108722012088 no 1454 0.448677113054847 2154 4456143 SGTC_1939 st074455 53.6 µM 0.127999544380957 0.4445026118666 no 1455 0.449074666803452 2191 1644229 SGTC_1112 tnp00069 1.16933 µM 0.12749986460707 0.44469851453892 no 1456 0.449272390167813 2166 145826 SGTC_1896 st058441 89 µM 0.127453800818495 0.444716574824591 no 1457 0.449290618251041 2031 688759 SGTC_1761 st044296 37 µM 0.127214651927067 0.444810340065424 no 1458 0.449385254520105 2142 1826700 SGTC_2584 androsterone 48.74 µM 0.125950215312448 0.445306150223705 no 1459 0.449885666532062 2193 2754130 A steroid. SGTC_162 k030-0015 37.8 µM 0.12588045912553 0.44533350547707 no 1460 0.44991327548905 2160 1809920 YMR134W ERG29 SGTC_2446 5162541 200 µM 0.125683134088288 0.445410888931124 no 1461 0.44999137651861 2084 1549321 SGTC_2533 agelasine 13.65 µM 0.123885053278474 0.446116124026477 no 1462 0.450703143765451 2194 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2131 toluylene red 5.2905 µM 0.123103954838277 0.446422536162098 no 1463 0.45101238979777 2065 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1279 0874-0590 65.2 µM 0.122164086870169 0.44679127337914 no 1464 0.451384533949903 2123 3523074 SGTC_2721 ifenprodil 61.44 µM 0.121769341424041 0.446946157100904 no 1465 0.451540847611162 2169 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_807 1315-0151 48 µM 0.120487688751526 0.447449086554569 no 1466 0.452048415775199 2216 4011080 SGTC_2541 muurolladie-3-one 83.07 µM 0.120179992576028 0.447569841291143 no 1467 0.452170283252078 2153 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1742 st038235 28.8875 µM 0.120117317495846 0.447594438594667 no 1468 0.452195107168004 2085 564103 YBR002C RER2 SGTC_2939 9044578 71.43 µM 0.119981835308507 0.447647610279985 no 1469 0.452248768662111 2150 2653634 SGTC_824 1304-0008 100 µM 0.119608465206297 0.447794148930122 no 1470 0.452396656802659 2098 768245 SGTC_2918 7977171 22.06 µM 0.119051802032783 0.448012638861021 no 1471 0.452617157742076 2165 2236483 SGTC_55 0767-0285 6.563 µM 0.118295270125625 0.448309602410988 no 1472 0.452916852489747 2187 3116166 SGTC_1836 st055642 81 µM 0.117094971683099 0.448780818233984 no 1473 0.453392397170696 2091 8571 SGTC_929 2805-0021 398 µM 0.115790380382333 0.449293059510988 no 1474 0.453909337287546 2096 3098024 SGTC_2485 5633444 17.78 µM 0.115634051377233 0.449354447003867 no 1475 0.453971287410996 2075 5724239 SGTC_1049 3226-0134 66 µM 0.115057454623372 0.449580876295234 no 1476 0.454199791084579 2187 5702385 SGTC_2778 tioconazole 65.09 nM 0.114002260123155 0.44999529317365 no 1477 0.454618000903701 2179 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2375 9072683 200 µM 0.113503976488849 0.450191007974062 no 1478 0.454815505337226 2213 16798029 SGTC_1384 3089-0840 101 µM 0.113049500486919 0.450369526669267 no 1479 0.454995655503424 2191 1069836 SGTC_253 dyclonine 31.25 µM 0.112524790273006 0.45057564593108 no 1480 0.455203657384249 2184 3180 An oral anasthetic. SGTC_3343 9148379 18.9835 µM 0.112197202787864 0.450704337230257 no 1481 0.455333523509648 2212 1955036 SGTC_2760 etidronate 98.04 µM 0.112163874577133 0.450717430361576 no 1482 0.455346736142914 2145 3305 A chelator and antioxidant. SGTC_947 3447-0010 211 µM 0.110682680590652 0.451299377755443 no 1483 0.455933990235308 2207 748350 SGTC_3317 9138495 8.753 µM 0.110578432073567 0.451340339989705 no 1484 0.45597532564633 2221 17020139 SGTC_1950 st077106 7.18 µM 0.108874493534841 0.452009939478424 no 1485 0.456651018785519 2061 13831864 SGTC_310 1273-0058 1.06 µM 0.108671266752654 0.452089810986922 no 1486 0.456731616331688 2193 2734232 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.107952181290599 0.452372439091413 no 1487 0.457016812126509 2155 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.10738956246496 0.452593586656474 no 1488 0.457239967283946 2204 6312947 SGTC_1481 3346-2004 36 µM 0.106974222960035 0.452756852844772 no 1489 0.457404714743057 2233 2770522 SGTC_2521 angolensin 13.4 µM 0.106778569815949 0.452833765088505 no 1490 0.457482324534812 2136 821428 A flavenoid. SGTC_2316 5844804 197.44 µM 0.106625048796606 0.45289411621939 no 1491 0.457543222899337 2217 776813 SGTC_1223 0764-0573 147 µM 0.106510859692835 0.452939006162971 no 1492 0.457588519816706 2184 1609797 SGTC_1572 epiandrosterone 68.9 µM 0.106350777428703 0.453001938607318 no 1493 0.457652022714544 2133 441302 A steroid. SGTC_3189 9110682 49.47 µM 0.105232605522081 0.453441553499433 no 1494 0.458095619442269 2115 17122418 SGTC_608 k048-0125 159 µM 0.10486705507875 0.453585283891605 no 1495 0.458240650514308 2210 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_244 nsc-207895 1.295 µM 0.104126730297436 0.453876390014569 no 1496 0.458534389223373 2193 42640 SGTC_996 3970-0799 1.8 µM 0.103730244359536 0.454032304065078 no 1497 0.458691712294665 2191 6615648 YGL040C HEM2 SGTC_1378 2093-0007 380 nM 0.102519022007468 0.454508648674421 no 1498 0.459172357509249 2128 3618014 SGTC_2898 9056270 58.44 µM 0.102049718691686 0.454693232002297 no 1499 0.459358605617405 2178 19154699 SGTC_2680 butyl paraben 22.24 µM 0.101865187066578 0.454765813462902 no 1500 0.459431841438676 2238 7184 An antifungal and steroid mimetic. SGTC_1600 coumarin 106 71.1 µM 0.101638932802522 0.454854807667686 no 1501 0.459521637772897 2174 100336 A hepatotoxic, DNA x-linker. SGTC_2121 5257820 149.641 µM 0.101296708591179 0.454989421464003 no 1502 0.459657464460016 2244 791256 SGTC_1352 1496-0991 99 µM 0.101188352587918 0.455032044345202 no 1503 0.459700471274261 2185 3000039 SGTC_1628 st004252 77.7 µM 0.100019304521615 0.455491933523008 no 1504 0.460164499751335 2198 692968 SGTC_217 ketoconazole 989 nM 0.0991290469146064 0.455842189991912 no 1505 0.460517904781278 2207 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3034 9090421 49.47 µM 0.0986386149270582 0.456035156659853 no 1506 0.46071260461548 2229 17173761 SGTC_649 1123-0311 367 µM 0.0986014467667426 0.456049781365915 no 1507 0.460727360633498 2228 693629 YIL048W NEO1 SGTC_2561 acetosyringone 100 µM 0.0984087122008547 0.456125618367997 no 1508 0.460803878462761 2265 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_252 miconazole 1.30953 nM 0.0982698658283439 0.456180252488897 no 1509 0.460859002961816 2237 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2634 4'-methoxyflavone 100 µM 0.0976971735275195 0.456405607707223 no 1510 0.461086380009797 2141 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1960 st011366 51.8 µM 0.097251146308001 0.456581129756982 no 1511 0.461263475810512 2226 3972846 SGTC_3045 9092950 49.47 µM 0.096241543062556 0.456978463275802 no 1512 0.461664368668075 2250 44120432 SGTC_1722 st034304 3.6505 µM 0.0955950807491179 0.457232903797527 no 1513 0.461921086150887 2167 4036148 YLR033W RSC58 SGTC_346 4513-0042 7.16 µM 0.0954103564293502 0.457305612501882 no 1514 0.461994445182766 2210 2827372 SGTC_994 3910-0338 138 µM 0.0953210273799485 0.457340773514658 no 1515 0.462029920632311 2204 3479481 SGTC_171 k064-0041 9.68 µM 0.0951400153596019 0.457412023096274 no 1516 0.462101807275569 2129 53325 SGTC_1664 st014217 9.02 µM 0.0948580883922297 0.457522997338571 no 1517 0.462213773483406 2245 3982782 SGTC_2929 9013348 24.6 µM 0.0943854708961904 0.457709040066027 no 1518 0.462401478412149 2169 2995952 SGTC_410 α-linolenic acid 100 µM 0.093494347371162 0.458059850079334 no 1519 0.462755420085493 2202 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2882 9058044 58.44 µM 0.0914611259413819 0.458860393478968 no 1520 0.463563096866977 2107 18076804 SGTC_1025 k007-0731 70 µM 0.0912200644645871 0.458955318112967 no 1521 0.463658866141052 2182 6256118 SGTC_766 1391-0721 126 µM 0.0905743685736782 0.459209590271215 no 1522 0.463915399557177 2239 1020919 YIL115C NUP159 SGTC_3085 9117376 49.47 µM 0.0898714444649741 0.459486417614581 no 1523 0.46419468665926 2152 16480349 SGTC_2262 9014885 67.46 µM 0.089701034323892 0.459553531929106 no 1524 0.464262396992917 2210 6457424 SGTC_1910 st062352 60.4 µM 0.0889920562605984 0.459832768136886 no 1525 0.464544111628814 2213 2245730 SGTC_2341 7987486 176.74 µM 0.0889388521067836 0.459853723783854 no 1526 0.464565253183353 2239 1258686 SGTC_3356 9151811 4.48 µM 0.088649599793416 0.459967654232296 no 1527 0.464680194145041 2179 1859254 YPR165W RHO1 SGTC_2163 5671233 125 µM 0.0872082096878158 0.460535436525585 no 1528 0.465253006916983 2242 701023 SGTC_2327 6189656 200 µM 0.0869730413036422 0.460628080074423 no 1529 0.465346470405412 2228 5349088 SGTC_2017 5132927 60.65 µM 0.0866338798318158 0.460761695004377 no 1530 0.465481267460768 2212 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1280 0880-0253 10.1 µM 0.0857728307484405 0.461100930915072 no 1531 0.465823502392839 2175 6836607 SGTC_2137 5261020 140 µM 0.0855490631152198 0.461189095477615 no 1532 0.465912445838661 2236 763655 SGTC_1685 st024049 53.0905 µM 0.084983640045567 0.461411880947851 no 1533 0.466137198502334 2181 1941139 SGTC_1096 rimcazole 32.2 µM 0.0849127512576135 0.461439813086924 no 1534 0.466165377181971 2143 18528119 A dopamine reuptake inhibitor. SGTC_3312 9133330 71.43 µM 0.0840785663021127 0.461768519236102 no 1535 0.466496982953031 2229 17617324 SGTC_1408 3909-7976 48.8 µM 0.0837349890406885 0.461903911636607 no 1536 0.466633568795389 2188 24152374 SGTC_1658 st012944 20 µM 0.0818966252864305 0.462628424427716 no 1537 0.467364459028791 2229 24207260 SGTC_398 bronopol 33.3 µM 0.0813965172839154 0.462825542256773 no 1538 0.467563309363578 2150 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2532 xanthone 78.9 µM 0.0809363834213424 0.463006912322451 no 1539 0.467746272540656 2230 7020 An insecticide. SGTC_541 4513-1321 94 µM 0.0804408879652406 0.463202229396872 no 1540 0.467943304178112 2083 747515 SGTC_2051 5263410 176 µM 0.0803459707196187 0.463239645403142 no 1541 0.46798104851046 2290 227584 SGTC_124 0136-0217 7.121 µM 0.0795435004885214 0.463555988987564 no 1542 0.468300166407872 2283 3976905 SGTC_698 k064-0052 127 µM 0.079364349820717 0.46362661552668 no 1543 0.468371411944526 2279 5088751 SGTC_1259 0671-0132 43 µM 0.0784464936889334 0.463988479736938 no 1544 0.468736445418271 2184 X1259 SGTC_1821 st053465 65.6 µM 0.0779056796610973 0.464201709299711 no 1545 0.468951540714426 2193 675086 SGTC_1513 0337-0559 19 µM 0.0778384898854761 0.464228201281734 no 1546 0.468978264406707 2103 775073 SGTC_2469 5655019 90.81 µM 0.0776281637403478 0.464311130942604 no 1547 0.469061919275318 2249 2788239 SGTC_403 arphamenine a 50 µM 0.0775301968594988 0.464349758910461 no 1548 0.469100884971454 2249 5487158 An arginine aminopeptidase inhibitor. SGTC_1327 1436-0082 2.18 µM 0.0773971228449443 0.464402230025531 no 1549 0.469153814777981 2126 15992205 SGTC_2023 5144124 124 µM 0.0758259984825181 0.465021771284968 no 1550 0.469778765933412 2229 2830192 SGTC_2387 9077560 195.08 µM 0.0744986821357949 0.465545237906504 no 1551 0.47030679487902 2232 5303272 SGTC_3318 9139014 38.6185 µM 0.0739145877701165 0.46577561181211 no 1552 0.470539174119698 2243 16643984 SGTC_2250 alverine citrate 130 µM 0.0737699053606117 0.465832678085434 no 1553 0.47059673690027 2245 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2861 9024595 19.48 µM 0.0733933497663626 0.465981204092555 no 1554 0.470746554721374 2284 16482810 SGTC_1527 coumarin 137 µM 0.072707326480257 0.466251806579785 no 1555 0.4710195091473 2219 323 A hepatotoxic, DNA x-linker. SGTC_2266 7929956 200 µM 0.0717096150599273 0.466645382537669 no 1556 0.471416502076688 2293 2967153 SGTC_645 0845-0943 5.41 µM 0.0716888653986558 0.466653568185756 no 1557 0.471424758743715 2204 1885106 SGTC_3111 9122088 49.47 µM 0.0714058722241579 0.466765209127359 no 1558 0.471537368091451 2274 16876704 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0710350563304893 0.466911500129929 no 1559 0.47168492751701 2146 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2713 st079149 53.4 µM 0.0701559954363382 0.4672583172717 no 1560 0.47203474926823 2209 3103253 SGTC_675 1309-0189 238 µM 0.0692921703514284 0.467599147625061 no 1561 0.472378528956895 2199 4246530 SGTC_895 0964-0006 13.7 µM 0.0692845107021782 0.467602169918704 no 1562 0.472381577388476 2273 6738897 SGTC_1455 4262-0120 131 µM 0.0692201770233551 0.467627554349074 no 1563 0.472407181342499 2250 1529587 SGTC_1643 st009866 20.2 µM 0.0684607669594435 0.467927208130367 no 1564 0.472709425100573 2280 3156273 YOR207C RET1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0665473143797807 0.46868231296613 no 1565 0.473471044869129 2233 4330530 SGTC_430 0958-0115 16.4 µM 0.0661001188366471 0.468858805863852 no 1566 0.473649058121036 2108 6833180 SGTC_2715 st079500 56.4 µM 0.0640534935482733 0.469666616949074 no 1567 0.474463816264339 2270 28246688 SGTC_1929 genistein trimethyl ether 50.5 µM 0.0623338770989441 0.470345453028158 no 1568 0.475148475448795 2318 136420 SGTC_13 0199-0087 65 µM 0.061843565911487 0.470539024232117 no 1569 0.475343704641994 2300 4589825 SGTC_2401 5128683 200 µM 0.0609216408223386 0.470903012203734 no 1570 0.475710807285512 2252 708373 SGTC_1941 st076221 61.8 µM 0.0607053965746342 0.470988391765728 no 1571 0.475796916882463 2310 2828568 SGTC_953 1188-0045 9.7 µM 0.0598089654739578 0.471342343195906 no 1572 0.476153892473114 2245 6144426 SGTC_76 0433-0009 400.328 µM 0.0596441894196007 0.47140740668528 no 1573 0.476219511463347 2135 2841569 SGTC_3268 9137683 49.47 µM 0.0564374508935049 0.472673769601496 no 1574 0.477496661493436 2276 1953228 SGTC_209 4077-0173 175.592 µM 0.0563084297745275 0.472724726788211 no 1575 0.477548051751151 2252 15993494 SGTC_1162 k048-0130 20.1 µM 0.056304328290466 0.472726346686069 no 1576 0.477549685414811 2250 6797406 SGTC_1027 k015-0025 8.67 µM 0.0555175530457968 0.47303709508895 no 1577 0.477863073103833 2321 3598955 SGTC_745 0469-0705 296 µM 0.0554324052784106 0.473070726433861 no 1578 0.477896989919095 2304 3486736 SGTC_1415 3966-0071 78.1 µM 0.0548658129851997 0.473294521803946 no 1579 0.478122684060677 2296 2893185 SGTC_1638 st008370 60.6 µM 0.0543076254040017 0.473515005683279 no 1580 0.478345037163559 2325 24207134 SGTC_1205 4161-2785 76 µM 0.0539234430379838 0.473666762287846 no 1581 0.478498079496116 2132 3498106 SGTC_2047 4141938 200 µM 0.053907612173674 0.473673015749697 no 1582 0.478504385924532 2243 3807862 SGTC_1056 3448-1962 115 µM 0.0526168869481653 0.474182895952914 no 1583 0.479018580884797 2252 715507 SGTC_1465 k213-0056 144 µM 0.0510491308377006 0.474802269547353 no 1584 0.479643185404682 2197 24048857 YMR208W ERG12 SGTC_213 1246-0773 967 nM 0.0510298885581141 0.474809871978458 no 1585 0.479650851971251 2246 6251622 SGTC_1944 st076371 56.9 µM 0.0509801472359228 0.474829524316996 no 1586 0.479670670092442 2268 24208455 SGTC_2171 5739187 198.077 µM 0.0507814113959657 0.47490804362872 no 1587 0.47974985166039 2310 2262761 SGTC_882 0843-0131 351 µM 0.0501739672535916 0.47514804711354 no 1588 0.47999187827 2329 5425421 SGTC_1024 4507-0395 26 µM 0.0491612537275523 0.475548194076333 no 1589 0.480395394477852 2218 4201836 SGTC_818 4072-2707 53.5 µM 0.0484818947780542 0.475816638642112 no 1590 0.480666096673275 2319 882871 SGTC_993 3909-8757 62.7 µM 0.0471461281325537 0.476344490621503 no 1591 0.481198381627973 2278 4288324 YLR208W SEC13 SGTC_817 1391-0715 46 µM 0.0456911246984233 0.476919508347661 no 1592 0.481778218943756 2284 1353946 SGTC_610 4215-0184 155 µM 0.0453348420657389 0.477060318705455 no 1593 0.481920208012448 2280 5605015 SGTC_3236 9132701 49.47 µM 0.0449786068577644 0.477201113183641 no 1594 0.482062180473974 2267 24282524 SGTC_2954 9074818 52.69 µM 0.0438857604660599 0.477633055430774 no 1595 0.48249773293373 2300 16648742 SGTC_1391 3442-0225 151 µM 0.0423439661374303 0.478242486745572 no 1596 0.483112248394017 2313 5227075 SGTC_568 1193-0097 7.48 µM 0.0423289435850523 0.478248425023542 no 1597 0.483118236156756 2322 3646150 SGTC_1556 plumbagin 1.48 µM 0.0417582432445927 0.478474021228446 no 1598 0.483345711510079 2329 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2103 5378138 10 µM 0.0389161864744223 0.479597579375337 no 1599 0.484478605702107 2343 244142 SGTC_2704 st078022 71.1 µM 0.0378551278686299 0.480017092644885 no 1600 0.484901595078609 2350 54697681 SGTC_667 1498-1044 59 µM 0.0378373433244073 0.480024124352425 no 1601 0.484908685005834 2287 6739982 SGTC_867 0518-0118 155 µM 0.0377706117925528 0.480050508925185 no 1602 0.484935288018804 2338 6848158 SGTC_803 4488-1585 147 µM 0.0375107147863013 0.480153268846991 no 1603 0.485038898498176 2332 747204 SGTC_1736 st036774 51 µM 0.037129653267588 0.480303938035937 no 1604 0.485190814217847 2341 1272247 SGTC_1082 camptothecin 424.86 nM 0.036342103673948 0.480615338798398 no 1605 0.485504789110614 2354 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2662 daunorubicin 22.37 µM 0.0363237839939771 0.480622582626363 no 1606 0.4855120927832 2315 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1982 st072467 71.9 µM 0.0346005933530287 0.481303981788164 no 1607 0.486199114178619 2274 3163533 SGTC_2749 bexarotene 57.39 µM 0.032901560866895 0.481975881612657 no 1608 0.486876544039674 2310 82146 An retinoic acid receptor inhibitor. SGTC_3261 9137475 49.47 µM 0.0327124297192615 0.482050678666848 no 1609 0.486951955857142 2347 17027690 SGTC_2690 usnic acid 100 µM 0.0326538946428865 0.482073828082331 no 1610 0.486975295505083 2340 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1065 prochlorperazine maleate 2.48 µM 0.0321537631348497 0.482271622235478 no 1611 0.487174714384113 2354 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3020 9089140 49.47 µM 0.0315816014792516 0.482497908529048 no 1612 0.487402857981708 2323 17217859 SGTC_3174 9107204 49.47 µM 0.0311375111973367 0.482673547299624 no 1613 0.487579937276797 2343 3938802 SGTC_415 dibenzyl ketone 100 µM 0.0310612307247182 0.482703716748672 no 1614 0.487610354069811 2336 7593 SGTC_1237 0330-0133 46.1 µM 0.0310211504113726 0.482719568826646 no 1615 0.487626336099773 2350 X1237 YHR072W ERG7 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0297842762337314 0.483208775562335 no 1616 0.488119549475943 2302 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1073 triclabendazole 3.09 µM 0.0297722751846824 0.483213522325405 no 1617 0.488124335079541 2305 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2300 7976697 71.57 µM 0.0295892489049871 0.483285914823377 no 1618 0.488197319845874 2325 2236109 SGTC_2956 9076196 2.52 µM 0.0294687191769699 0.483333588322544 no 1619 0.488245383291105 2363 16423868 SGTC_196 k015-0023 18.111 µM 0.0294372989988135 0.483346016082769 no 1620 0.488257912692949 2331 5211998 SGTC_245 methotrexate 289.6 µM 0.0289313631407427 0.483546133320828 no 1621 0.488459665958288 2285 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1880 MG-132 525 µM 0.0281499061797354 0.483855237959646 no 1622 0.488771295224985 2349 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_305 1682-2595 20.8 µM 0.0280839203041984 0.483881339063654 no 1623 0.488797609377116 2314 226033 SGTC_1235 benzylparaben 21.5 µM 0.0279960134925918 0.483916111231081 no 1624 0.488832665337086 2319 7180 SGTC_1416 3966-0321 25.3 µM 0.0270352115860941 0.484296171207944 no 1625 0.489215824751781 2344 582530 YLR208W SEC13 SGTC_573 3702-0553 84.7 µM 0.0267123832725869 0.484423874133824 no 1626 0.489344568117103 2349 1222756 SGTC_2789 5281112 71.43 µM 0.0265302433357462 0.484495924910484 no 1627 0.489417205695278 2342 765948 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0256747621600302 0.484834342232316 no 1628 0.489758377049203 2331 1609 A potent and irreversible inhibitor of serine proteases. SGTC_116 0155-0182 31.788 µM 0.0244848947495066 0.485305056547291 no 1629 0.490232916173845 2322 771486 SGTC_3100 9120536 49.47 µM 0.0230891670119975 0.485857235736321 no 1630 0.490789573428123 2373 16421196 SGTC_3064 1327-0027 10 µM 0.0220742845767489 0.486258761618613 no 1631 0.491194349705994 2330 16000455 YPR107C YTH1 SGTC_264 promethazine 12.5 mM 0.0217199774228732 0.486398942232931 no 1632 0.491335663926145 2368 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_535 2293-4129 48.2 µM 0.0208640090338781 0.486737610584207 no 1633 0.491677068500303 2375 396118 YIL048W NEO1 SGTC_3138 9097216 49.47 µM 0.0197080718160594 0.487194978299968 no 1634 0.492138125826608 2383 25237486 SGTC_2635 hydroquinidine 100 µM 0.0192284325647635 0.487384761326501 no 1635 0.492329437943147 2368 442912 An experimental heart treatment. SGTC_1837 st055472 66.5 µM 0.0185898268127403 0.487637448435084 no 1636 0.492584159231279 2340 676091 SGTC_2491 paeonol 100 µM 0.0184460632480661 0.487694334297333 no 1637 0.492641502762759 2357 11092 Increases levels of cortical cytochrome oxidase. SGTC_1791 st048313 56.1 µM 0.0175669889940286 0.488042180942628 no 1638 0.492992145789042 2373 1204976 SGTC_653 0203-0016 55.2 µM 0.0173566845712102 0.488125399034539 no 1639 0.493076032324768 2359 295302 SGTC_2731 amoxapine 43.43 µM 0.0161887756046078 0.488587553429159 no 1640 0.493541895030833 2375 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2910 7948405 25.97 µM 0.0158115170612137 0.488736842079237 no 1641 0.493692380149863 2365 2971328 SGTC_738 1315-0003 72.4 µM 0.0156834750518708 0.488787511188731 no 1642 0.493743455187743 2372 6251474 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0155595518196057 0.488836550577624 no 1643 0.493792887372708 2368 279621 SGTC_1754 st042065 16.137 µM 0.0142431410337075 0.48935749610362 no 1644 0.494318000951663 2364 1126236 YIL048W NEO1 SGTC_1008 4106-0037 6 µM 0.0136125705248476 0.489607039352101 no 1645 0.494569537785864 2380 2905394 SGTC_2170 morpholine 200 µM 0.0135475413765269 0.489632774351849 no 1646 0.494595478270527 2367 121171 Reacts with secondary amines. SGTC_2421 5690543 90.72 µM 0.0120235070068874 0.490235916387376 no 1647 0.495203430265656 2353 3397993 SGTC_2864 9034755 47.6 µM 0.0101011572633643 0.490996724824159 no 1648 0.495970289814267 2388 4930451 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.00954195831324826 0.491218045288608 no 1649 0.496193367156104 2368 689007 SGTC_917 harmaline 728.087 nM 0.00866815536361596 0.491563885507703 no 1650 0.49654194963696 2381 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3242 9133940 49.47 µM 0.0083811263970435 0.491677489359601 no 1651 0.496656453466489 2387 17248444 SGTC_442 cape 100 µM 0.00822430137699071 0.491739559779146 no 1652 0.496719015441155 2392 5281787 SGTC_300 r073-0011 5.04 µM 0.00772974413570636 0.491935303926203 no 1653 0.496916308955493 2384 2735780 SGTC_1142 3253-1408 9.78 µM 0.00741091398129902 0.492061496896547 no 1654 0.497043500139106 2383 256655 SGTC_432 NS 1619 61.3 µM 0.00609084123961641 0.492583989982195 no 1655 0.497570120930396 2344 4552 A K+/calcium channel activator. SGTC_1787 fluconazole 80 µM 0.0052009617483364 0.49293621711098 no 1656 0.497925125814068 2391 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2235 salicylic acid 500 µM 0.00499988026089028 0.493015808834648 no 1657 0.498005344677656 2392 338 A COX inhibitor and kinase inhibitor. SGTC_2295 7971645 200 µM 0.004668520783429 0.493146967570244 no 1658 0.498137536437985 2387 2978226 YKL099C UTP11 SGTC_1605 st000082 49.1 µM 0.00427534891514642 0.493302593851383 no 1659 0.498294387750318 2382 1114022 SGTC_3089 9117425 49.47 µM 0.0011724044343046 0.494530843026018 no 1660 0.499532278408576 2400 9401657 SGTC_2879 9041815 71.43 µM 0.000148725349523097 0.494936061380078 no 1661 0.499940667170126 2404 4942971 SGTC_460 trequinsin 123 µM -7.81127513309176e-05 0.495025854853653 no 1662 0.499968837520887 2407 5537 A vasodilator. SGTC_385 1494-0393 12.4 µM -0.000156423918853853 0.495056854253896 no 1663 0.499937595885358 2406 3090647 SGTC_2490 carminic acid 95.39 µM -0.00139895842701017 0.495548714212243 no 1664 0.499441896516984 2402 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2261 9010538 184.68 µM -0.00434541529993248 0.49671510118758 no 1665 0.498266435566666 2424 6457250 SGTC_2216 7189485 200 µM -0.00443989511793957 0.496752502568237 no 1666 0.498228743936272 2413 731273 SGTC_1940 st075990 51.1 µM -0.00464621011082165 0.496834175830093 no 1667 0.498146437012061 2457 1084979 SGTC_1113 artemisinin 1.17947 µM -0.00570680888347112 0.497254033722075 no 1668 0.497723325007885 2417 2240 An anti-malaria and mitochondrial poison. SGTC_966 1300-0360 30.2 µM -0.00572415023267778 0.497260898646547 no 1669 0.497716406923484 2416 70588 SGTC_3145 9085516 49.47 µM -0.00595854117967827 0.497353687131131 no 1670 0.497622900060099 2426 25236195 SGTC_1189 1431-2119 7.28 µM -0.00652279705260009 0.497577060019005 no 1671 0.497397798921843 2416 3107275 SGTC_1211 1056-0033 32.3 µM -0.0068115644230391 0.497691375124698 no 1672 0.497282599969375 2418 6741922 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.00894123509344146 0.498534458746127 no 1673 0.496433010809846 2427 688788 SGTC_1693 xanthone 101.9 µM -0.00905347463018037 0.498578891800182 no 1674 0.496388235525502 2440 7020 An insecticide. SGTC_797 k781-0471 270 µM -0.00963489396522028 0.498809062627557 no 1675 0.496156292899493 2454 23738129 SGTC_787 4152-0075 138 µM -0.0106338219791968 0.499204516625913 no 1676 0.495757798760446 2437 9566539 SGTC_593 1203-0218 61.7 µM -0.0115023875529705 0.499548363602376 no 1677 0.495411312464102 2423 3666956 SGTC_1164 k060-0068 93.7 µM -0.0120766958418677 0.499775720463461 no 1678 0.495182212531055 2424 5963676 SGTC_983 1491-0821 12.2 µM -0.0132097652823392 0.499775720463461 no 1679 0.494730219376083 2439 46495113 SGTC_2471 5466956 24.79 µM -0.0134044028341893 0.49969866744072 no 1680 0.494652577102111 2463 724419 SGTC_715 0868-0130 184 µM -0.0147063211445445 0.499183265059856 no 1681 0.494133238180223 2446 2876258 SGTC_2859 9028643 45.46 µM -0.015774745832492 0.498760298927706 no 1682 0.493707047918348 2456 17151580 SGTC_2807 7945238 51.95 µM -0.0158807125954716 0.498718349055583 no 1683 0.493664778591222 2453 17148797 SGTC_2055 5235184 200 µM -0.0165946312245041 0.498435725025532 no 1684 0.493380003815998 2443 2836034 SGTC_2139 5578692 56.4705 µM -0.017277253012769 0.498165491430032 no 1685 0.493107716180827 2440 650991 YMR113W FOL3 SGTC_3216 9129716 49.47 µM -0.0173438026897887 0.498139146051915 no 1686 0.493081170678458 2447 8056934 SGTC_633 0437-0093 97.7 µM -0.0177372543901444 0.49798338838351 no 1687 0.492924230305693 2432 2831118 SGTC_625 k213-0058 121 µM -0.0182029538637981 0.497799030031296 no 1688 0.492738473092582 2455 3655420 SGTC_2722 naftopidil 47.16 µM -0.0183075635211561 0.497757617842338 no 1689 0.492696746830654 2441 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_421 streptovitacin 30 mM -0.0185383364090285 0.497666261062522 no 1690 0.492604697391065 2545 91467 include heat shock SGTC_3035 9091303 49.47 µM -0.0190587155966004 0.497460257393921 no 1691 0.492397132811944 2443 25237002 SGTC_1932 st074806 40.9 µM -0.0197524955589847 0.497185610236988 no 1692 0.492120406766513 2573 17251235 SGTC_428 3448-4153 16.5 µM -0.0201251922505471 0.497038071080579 no 1693 0.491971751851718 2434 3834874 SGTC_1084 voriconazole 435 nM -0.021262616086361 0.496587802560164 no 1694 0.491518082566865 2443 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1255 0566-0045 221 µM -0.0216119426076593 0.496449516576727 no 1695 0.491378753467068 2476 2788469 SGTC_304 1310-0298 97 µM -0.0219925029872454 0.496298866702389 no 1696 0.491226967921245 2454 1550234 SGTC_912 3474-0017 2.18 µM -0.022206245052766 0.496214254300588 no 1697 0.491141717994192 2467 3360550 SGTC_2919 7978188 46.38 µM -0.0224766996490161 0.496107191796827 no 1698 0.491033849145411 2437 2980291 SGTC_3106 9121286 49.47 µM -0.0229008183481357 0.495939300191513 no 1699 0.490864693810168 2554 15943471 SGTC_2784 7567673 72.73 µM -0.0236127169691361 0.495657489673826 no 1700 0.490580764152814 2445 3471247 SGTC_1451 4152-0210 104 µM -0.0244998495712804 0.495306314492497 no 1701 0.49022695185234 2447 659563 SGTC_8 0354-0001 70 µM -0.0249053610748865 0.495145792248777 no 1702 0.490065225521215 2442 4993152 SGTC_3053 9095903 49.47 µM -0.0250220256630631 0.495099610567824 no 1703 0.49001869758443 2448 17174018 SGTC_2934 9036370 36.88 µM -0.0258894989001574 0.494756223360539 no 1704 0.489672737952241 2483 6462800 SGTC_2994 9053520 71.4286 µM -0.0266021194960231 0.49447413709674 no 1705 0.489388541372876 2463 4647384 SGTC_832 4083-0019 164 µM -0.0277857297316653 0.494005618798224 no 1706 0.488916523796925 2508 1990758 SGTC_49 0717-0965 32.132 µM -0.0280832118961804 0.493887865230056 no 1707 0.488797891879601 2640 5889349 YGL099W LSG1 SGTC_1418 3966-3099 2.4 µM -0.0282141534834582 0.493836034260247 no 1708 0.488745674435511 2445 740335 SGTC_39 0986-0283 58.349 µM -0.0284705518008829 0.493734543708949 no 1709 0.48864342738156 2467 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1239 0337-0584 35.4 µM -0.0292279882416084 0.493434728838936 no 1710 0.488341379688196 2477 914301 YML130C ERO1 SGTC_1323 1348-1351 11.2 µM -0.0313722052300064 0.492586007485023 no 1711 0.487486353624938 2473 6989654 SGTC_1281 0884-0031 11.8 µM -0.0327986358799862 0.492021417796823 no 1712 0.486917583019493 2471 1548255 SGTC_2682 pyrogallin 40.03 µM -0.0331692669854377 0.491874722383511 no 1713 0.486769803011779 2472 822798 An ATP competetive kinase inhibitor. SGTC_3295 9122362 53.5725 µM -0.0335507998251981 0.491723713222974 no 1714 0.486617678104398 2492 4730473 SGTC_550 4123-0385 25.7 µM -0.0348442487574782 0.491211780302896 no 1715 0.486101968315617 2489 5731123 SGTC_2618 avocadyne 43.43 µM -0.0349388129792822 0.491174353377306 no 1716 0.486064265606322 2479 3015189 SGTC_290 2043-6722 48.1 µM -0.0350794934874898 0.491118674546494 no 1717 0.486008176586646 2496 773758 YLR208W SEC13 SGTC_3341 9147222 25.867 µM -0.0354484672285158 0.490972642159284 no 1718 0.485861068858053 2524 1939759 SGTC_1185 1319-0113 81.3 µM -0.0367346366340697 0.490463611758305 no 1719 0.485348295615763 2520 4672763 SGTC_2903 5923464 63.88 µM -0.0368167734781153 0.490431104778117 no 1720 0.4853155499069 2478 2876576 SGTC_2217 6934799 96.0675 µM -0.0369846171516342 0.490364678136324 no 1721 0.485248635541977 2471 675606 SGTC_368 fentichlor 4.58 µM -0.0396128925378551 0.489324534909575 no 1722 0.4842008743743 2505 7329 A pesticide. SGTC_1143 3454-2408 5.08 µM -0.039765115242645 0.489264294742465 no 1723 0.484140194112497 2463 X1143 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0407279439672253 0.488883273454445 no 1724 0.48375639200429 2480 147795 SGTC_1970 st070122 35.8 µM -0.0409104812641448 0.488811038899224 no 1725 0.48368363080181 2529 102928 SGTC_1475 4092-1048 11.7 µM -0.042336026152994 0.48824692808793 no 1726 0.483115413151552 2511 2881759 SGTC_1483 3453-0561 55.9 µM -0.0431113025788 0.487940148660204 no 1727 0.482806404761047 2546 4546991 SGTC_2165 5727197 32.143 µM -0.0432641951897589 0.487879649388575 no 1728 0.482745466291399 2730 1361712 SGTC_471 1-acyl-paf 4 µM -0.0439849961378544 0.487594433810646 no 1729 0.482458181820073 2478 16759367 SGTC_67 0335-0847 266 µM -0.0442159381320839 0.487503053115053 no 1730 0.482366138842939 2634 4552207 YOR254C SEC63 SGTC_1176 0848-0131 83.3 µM -0.0444498992397001 0.487410478465233 no 1731 0.482272893542907 2516 6769040 SGTC_150 3970-0969 77.2 µM -0.0457442750005439 0.486898327175324 no 1732 0.481757037188676 2615 6615640 SGTC_108 0509-0257 621.132 µM -0.0468840871398743 0.486447350609295 no 1733 0.481302805384854 2496 536624 SGTC_2405 ticlatone 3.52 µM -0.0473947607451046 0.486245303752522 no 1734 0.481099302324755 2464 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_781 4335-2806 94.4 µM -0.0481570235313591 0.485943722789702 no 1735 0.480795550338182 2623 845254 SGTC_1564 D-Arginine 115 µM -0.0481781458062372 0.485935366105549 no 1736 0.480787133539316 2510 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2909 7941780 10.49 µM -0.0489306226353736 0.485637664956497 no 1737 0.480487292374616 2486 1243215 SGTC_2223 6903751 107.57 µM -0.0510761602996616 0.484788873990511 no 1738 0.479632416258348 2566 5598863 SGTC_1962 st076595 64.5 µM -0.0511593434394403 0.48475596747276 no 1739 0.479599274315537 2503 279619 SGTC_2551 apiole 73.87 µM -0.0517221878237012 0.484533313928687 no 1740 0.479375028786605 2496 10659 A possible DNA adduct former. SGTC_2140 5586273 200 µM -0.0520626436534822 0.484398636592895 no 1741 0.479239389311687 2497 854421 SGTC_512 prima-1 270 µM -0.0521216922505803 0.484375278360991 no 1742 0.479215864270078 2603 322968 A re-activator of the apoptotic function of mutant p53. SGTC_319 1348-1596 45.5 µM -0.0524201295070964 0.48425722444518 no 1743 0.47909696756949 2598 5380505 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0528959163522848 0.484069018562636 no 1744 0.478907419060968 2484 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_907 3448-6986 75.5 µM -0.0544909040753491 0.483438119155283 no 1745 0.478272027660307 2534 590582 SGTC_1729 st035615 45.989 µM -0.0553094965848251 0.483114339856841 no 1746 0.477945948284249 2636 17385451 SGTC_2379 9035213 200 µM -0.0554813948128133 0.48304635006361 no 1747 0.477877475952896 2490 646551 SGTC_2788 5282734 71.43 µM -0.0565277433892389 0.482632505291378 no 1748 0.477460697412888 2554 743706 SGTC_2414 st077232 92.9 µM -0.057168468881006 0.482379099050409 no 1749 0.477205497627278 2513 729801 SGTC_1181 1222-0449 220 µM -0.0571830316021952 0.482373339592233 no 1750 0.477199697430445 2557 658318 SGTC_1445 4239-0156 97.7 µM -0.0575148602361834 0.48224210460104 no 1751 0.477067534473382 2622 4008346 SGTC_2856 9022925 19.48 µM -0.0577168639967895 0.48216221502347 no 1752 0.476987080280865 2586 4944862 SGTC_80 0159-0065 512.242 µM -0.0584786910033879 0.481860929887106 no 1753 0.476683667779205 2497 1548079 SGTC_1456 k015-0012 13 µM -0.0587165660231085 0.481766857878054 no 1754 0.476588932162304 2507 2989616 SGTC_596 1155-0152 116 µM -0.0593952922189098 0.481498448840777 no 1755 0.476318631353296 2520 280313 SGTC_2212 7123476 200 µM -0.0594808832490692 0.481464601608009 no 1756 0.476284545736068 2513 1085715 SGTC_259 usnic acid 108.925 µM -0.0603276373522801 0.48112975736514 no 1757 0.47594734530168 2631 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1839 st053978 48 µM -0.0604202339460901 0.481093141355774 no 1758 0.475910471868731 2503 3788398 SGTC_2213 7173844 200 µM -0.0618057686581791 0.480545270531976 no 1759 0.475358754773938 2513 892728 SGTC_2085 5307070 144.047 µM -0.0622651863773943 0.480363614747756 no 1760 0.47517582595353 2513 2840351 SGTC_755 1995-0008 37.3 µM -0.0632301241687636 0.479982087428564 no 1761 0.474791628574513 2500 689533 SGTC_1855 st056195 39.6 µM -0.0635951510383423 0.479837764002429 no 1762 0.474646296419619 2546 4028379 SGTC_2863 9028737 58.44 µM -0.0651667672794018 0.479216412663587 no 1763 0.474020610366896 2633 6460917 SGTC_2829 7992743 58.44 µM -0.0654505000293417 0.479104241937645 no 1764 0.473907658516137 2538 16462845 SGTC_601 0986-0029 62.9 µM -0.0656308654828643 0.479032937233143 no 1765 0.473835857490193 2533 24747981 SGTC_1240 0356-0016 42.1 µM -0.066861498636896 0.478546443393786 no 1766 0.47334598202754 2585 4305613 SGTC_3126 9127922 49.47 µM -0.067143147208554 0.478435106562472 no 1767 0.473233872434533 2695 45595682 SGTC_1853 st056710 91.2 µM -0.0674918920406523 0.478297248638126 no 1768 0.473095058261758 2655 269167 SGTC_2304 7443016 91.4 µM -0.0687490281059448 0.477800327692972 no 1769 0.472594695853943 2519 939854 SGTC_1816 st051957 91.6 µM -0.0702265721803076 0.477216328010796 no 1770 0.472006662495529 2525 674121 SGTC_2340 7987427 183.45 µM -0.0702756740128366 0.477196921331681 no 1771 0.471987121976415 2595 2239331 SGTC_2524 avocatin b 10.57 µM -0.0706494748025168 0.477049184589677 no 1772 0.471838366779449 2566 6710748 SGTC_2846 9008642 19.48 µM -0.0714103206695255 0.476748486351068 no 1773 0.471535597937381 2639 2992898 SGTC_439 amiodarone 34.4 µM -0.0717239651315225 0.476624532976646 no 1774 0.471410791929793 2622 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_12 0849-0099 9.267 µM -0.0722857276360313 0.47640252815623 no 1775 0.471187261339167 2511 6071388 SGTC_1366 1683-0113 21.9 µM -0.0724532343227692 0.47633633203776 no 1776 0.471120610604719 2537 708623 SGTC_509 pifithrin 175 µM -0.0729324530342936 0.476146955637105 no 1777 0.470929934457247 2527 4817 A p53 inhibitor. SGTC_459 nigericin 15.3 µM -0.0731517895263018 0.476060280608903 no 1778 0.470842664965882 2610 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1974 st069448 26.9 µM -0.074192359792157 0.475649094783053 no 1779 0.470428662550096 2557 6323587 YNR016C ACC1 SGTC_1286 0929-0070 131 µM -0.074413649163147 0.47556165466314 no 1780 0.470340624226722 2605 1420408 SGTC_2432 5630864 12.22 µM -0.0750685768809863 0.475302873916845 no 1781 0.470080074636884 2633 5714970 SGTC_1000 4048-0884 8.67 µM -0.0756321574443953 0.475080195389789 no 1782 0.46985587589307 2631 13040088 SGTC_3218 9131285 49.47 µM -0.0763698026525541 0.474788753270266 no 1783 0.469562446708496 2558 17156417 SGTC_3014 9081533 49.47 µM -0.0764032957406778 0.474775520538351 no 1784 0.469549123825176 2569 21367265 SGTC_2347 9049783 174.81 µM -0.0789281465052132 0.473778062344382 no 1785 0.468544887699569 2614 6467988 YPL169C MEX67 SGTC_3153 9100258 49.47 µM -0.0794677917973468 0.473564893181279 no 1786 0.468330274496393 2588 25236848 SGTC_1380 2291-0730 164 µM -0.0799869458279719 0.473359825561665 no 1787 0.468123819211361 2604 2999191 SGTC_2466 5983409 37.09 µM -0.0811309470791096 0.472907966146001 no 1788 0.467668907296598 2601 2879657 SGTC_1194 1488-0194 225 µM -0.0813065121442555 0.472838624251075 no 1789 0.467599097598575 2542 1391452 SGTC_2270 7924575 90.91 µM -0.0833075888576182 0.472048329492928 no 1790 0.46680348311838 2720 1262135 SGTC_1163 k060-0048 49.9 µM -0.0833724162439491 0.472022728727823 no 1791 0.4667777103916 2537 6809982 SGTC_1967 st070177 51.4 µM -0.0841316131820814 0.471722925449622 no 1792 0.4664758950263 2639 5729214 SGTC_536 3852-0578 10.6 µM -0.0863467340827511 0.470848276879635 no 1793 0.465595394373655 2691 2869208 SGTC_605 1315-0399 119 µM -0.0888606176921633 0.469855831318608 no 1794 0.464596341109609 2660 24020461 SGTC_2108 5365811 200 µM -0.0891268263901608 0.469750746759745 no 1795 0.464490558926599 2633 780283 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0911329567682179 0.468958905048909 no 1796 0.463693472938847 2538 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1009 4106-0057 9.87 µM -0.0925897594349441 0.468383965790122 no 1797 0.463114739792898 2552 2928005 SGTC_1231 0242-0792 125 µM -0.0939015714443825 0.467866304679761 no 1798 0.462593672761598 2565 3707635 SGTC_1588 farnesol 29.9 µM -0.094981837284679 0.467440055990017 no 1799 0.462164626718775 2580 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1768 st044301 37.178 µM -0.095180139176249 0.467361814549041 no 1800 0.462085872500441 2607 3931349 SGTC_871 0574-0004 149 µM -0.0953298703087572 0.467302737886592 no 1801 0.462026408806307 2587 9551173 SGTC_3169 9102970 49.47 µM -0.0955728147741998 0.467206885284569 no 1802 0.461929928504138 2560 17027839 SGTC_2948 9070189 9.45 µM -0.0971599421856878 0.46658073863268 no 1803 0.461299689496176 2642 6473636 YDL196W YDL196W SGTC_2076 5212012 200 µM -0.0973394905757477 0.466509909155625 no 1804 0.461228397970498 2558 604802 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0978447273739528 0.466310605586198 no 1805 0.461027795222746 2592 279621 SGTC_2275 7947463 200 µM -0.0980054692853032 0.466247198599595 no 1806 0.460963975208317 2555 1225414 SGTC_511 blebbistatin 171 µM -0.0987921447469383 0.465936895399492 no 1807 0.460651652783218 2722 3476986 A myosin inhibitor. SGTC_1653 st012112 65 µM -0.0993615191213525 0.465712319261403 no 1808 0.460425617408258 2680 720429 SGTC_2719 novobiocin 32.65 µM -0.0995266736387779 0.465647180041915 no 1809 0.46036005526752 2614 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2804 7954240 19.48 µM -0.0998853679563127 0.465505709228538 no 1810 0.460217666465444 2680 828705 SGTC_1695 st026914 34.495 µM -0.100422491086506 0.465293873365623 no 1811 0.460004457357611 2574 3289191 SGTC_589 1227-0070 34.1 µM -0.103911458385573 0.46391810247138 no 1812 0.458619806929781 2677 2841384 SGTC_697 0508-1955 564 µM -0.104230467831559 0.463792331821435 no 1813 0.458493227907715 2595 6243113 SGTC_2772 vinpocetine 57.06 µM -0.107493063162079 0.46250625153384 no 1814 0.457198914116376 2690 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_133 0724-0033 378.92 µM -0.107679856754223 0.46243263122389 no 1815 0.457124824287253 2573 280309 SGTC_1678 st019265 80.2 µM -0.107840907954764 0.462369157706389 no 1816 0.457060946119139 2631 5367020 SGTC_1173 0443-0020 122 µM -0.108560099653044 0.462085721509322 no 1817 0.456775704755711 2622 5331295 SGTC_313 3474-0040 5.03 µM -0.109947966962543 0.461538812247639 no 1818 0.456225320487496 2587 1043375 YIL048W NEO1 SGTC_1907 st060210 83.7 µM -0.110645265196795 0.46126405913888 no 1819 0.455948825697807 2697 688793 SGTC_131 0141-0277 33.849 µM -0.111456400124534 0.460944474769425 no 1820 0.455627218889131 2716 1547771 SGTC_2018 5133068 143 µM -0.112107773162878 0.460687854284443 no 1821 0.455368977094752 2604 785362 SGTC_2040 5100729 123 µM -0.112407363569823 0.460569830579242 no 1822 0.45525020852425 2602 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2298 7976326 193.81 µM -0.113057740620288 0.460313626369584 no 1823 0.454992389106774 2651 2235818 SGTC_527 4476-4215 268 µM -0.115146015231268 0.459491100474618 no 1824 0.45416469377721 2617 4418754 SGTC_2700 st077718 96.8 µM -0.116197662709534 0.459076944846872 no 1825 0.45374794454696 2677 904970 SGTC_3182 9108849 49.47 µM -0.116276458920599 0.459045915419261 no 1826 0.453716721052088 2679 17133045 SGTC_315 k915-0449 187 µM -0.116384063919173 0.459003541684412 no 1827 0.453674082355855 2640 20970215 YNL149C PGA2 SGTC_2331 7980721 200 µM -0.117267765313581 0.458655566883883 no 1828 0.453323934152162 2716 2981221 SGTC_1596 piperlongumine 63 µM -0.117557928540478 0.458541316303444 no 1829 0.45320897093907 2754 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_102 gallobenzophenone 83.616 µM -0.11761242421689 0.458519859236106 no 1830 0.453187380087286 2708 70837 SGTC_1612 st002233 45.4 µM -0.118009722107116 0.458363431260891 no 1831 0.453029977293038 2616 1035021 SGTC_2442 5158906 48.48 µM -0.119332005597036 0.457842855568981 no 1832 0.452506163928877 2735 1893835 SGTC_992 3909-8734 162 µM -0.119901012510922 0.457618862897894 no 1833 0.452280781197852 2661 4288319 SGTC_377 3970-0964 33.1 µM -0.120337463863995 0.457447060564027 no 1834 0.452107913929574 2613 16481235 SGTC_1515 3460-0031 42.1 µM -0.120512669030586 0.45737809599126 no 1835 0.452038522176063 2638 2876596 SGTC_172 1112-0046 2.638 µM -0.120681593249605 0.457311604951591 no 1836 0.45197161944176 2673 2802135 YIL048W NEO1 SGTC_2606 farnesol 9.78 µM -0.122491054559385 0.45659944988038 no 1837 0.451255065036496 2716 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_225 nsc-122657 1.016 µM -0.124838688346048 0.45567569271769 no 1838 0.450325629045359 2743 275685 SGTC_6 0844-0013 19.835 µM -0.125064969090352 0.455586667364503 no 1839 0.450236058059884 2669 1584900 SGTC_1331 1472-0049 76.2 µM -0.125245000059469 0.455515839595833 no 1840 0.450164796399011 2626 24051409 SGTC_2677 mitomycin C 100 µM -0.12602937200268 0.455207268580162 no 1841 0.449854337222685 2641 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1272 0839-0021 27 µM -0.126615185870311 0.454976827699161 no 1842 0.449622488546568 2705 5027250 SGTC_1230 0170-0365 3.77 µM -0.128666324312827 0.454170093783383 no 1843 0.448810841585203 2719 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3269 9137823 49.47 µM -0.129938119960239 0.45366997816032 no 1844 0.448307692285453 2630 17682936 SGTC_2398 5228213 48.84 µM -0.130029285411715 0.453634131450133 no 1845 0.448271628485575 2688 80771 YMR134W ERG29 SGTC_630 4356-0227 183 µM -0.130084026333092 0.45361260722833 no 1846 0.448249973934685 2637 779312 SGTC_1207 2099-0101 141 µM -0.130305455213276 0.453525542413434 no 1847 0.448162382117297 2726 5837381 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.130809010259693 0.453327555212695 no 1848 0.447963197544845 2757 5393153 SGTC_395 anisomycin 6.25 µM -0.131318957756201 0.453127066458034 no 1849 0.447761497766789 2681 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2887 9044784 58.44 µM -0.131943427870172 0.45288156876426 no 1850 0.447514519205155 2654 6465546 SGTC_2793 7325131 81.82 µM -0.132052565832387 0.452838665245612 no 1851 0.447471357116997 2726 4176441 SGTC_3142 9086498 49.47 µM -0.132561701066633 0.452638525003815 no 1852 0.447270011577352 2719 25236367 SGTC_2437 5741531 144.16 µM -0.132730948227819 0.45257199687914 no 1853 0.447203083131212 2763 2262990 SGTC_1496 4469-0713 57.4 µM -0.133075024803517 0.452436750449639 no 1854 0.44706702338544 2635 746691 SGTC_1909 st060837 51.5 µM -0.133186543920899 0.45239291673258 no 1855 0.447022926215974 2695 678937 SGTC_918 glabranin 770.725 nM -0.133245252352186 0.45236984102295 no 1856 0.446999711843758 2693 124049 Also referred to as licorice root. SGTC_2525 harmine 47.85 µM -0.134274340045535 0.451965377977937 no 1857 0.446592821576271 2733 5280953 A monoamine oxidase inhibitor SGTC_1411 3909-8223 150 µM -0.134673957621135 0.451808329421244 no 1858 0.446434832192303 2674 X1411 SGTC_2378 9074213 121.43 µM -0.136540806183385 0.451074763609425 no 1859 0.445696883964132 2652 657714 SGTC_2135 5326629 150.42 µM -0.136738018948803 0.450997279868819 no 1860 0.445618938494564 2691 5020077 SGTC_37 0566-0070 1.56 µM -0.1381116551787 0.450457638196815 no 1861 0.445076087276858 2771 1626686 SGTC_1948 st076329 66.6 µM -0.13914486501281 0.450051795477011 no 1862 0.444667837940935 2627 24208413 SGTC_2093 5331342 194.4 µM -0.139166406644405 0.450043334522339 no 1863 0.444659326878865 2765 33839 SGTC_2117 5521686 200 µM -0.139285957113623 0.449996378830799 no 1864 0.444612093155285 2661 803312 SGTC_3123 9126162 49.47 µM -0.139412193190283 0.449946798001273 no 1865 0.444562218839228 2664 25239884 SGTC_1345 1488-0192 31.4 µM -0.140508130694732 0.449516387482526 no 1866 0.444129264427114 2691 658348 SGTC_1531 st059297 52.4 µM -0.141089544325622 0.44928807140348 no 1867 0.443899601722825 2757 7566702 SGTC_1608 st001473 40.5 µM -0.141844708002839 0.448991550267675 no 1868 0.443601334595205 2644 7292267 SGTC_3093 9117344 49.47 µM -0.142880749574711 0.448584786535118 no 1869 0.443192181092035 2812 24824913 SGTC_1734 st037168 69.4 µM -0.142895928349046 0.448578827546613 no 1870 0.443186187140071 2766 708907 SGTC_973 1325-0077 65.9 µM -0.143474122123484 0.448351844874382 no 1871 0.442957873673108 2740 2835149 SGTC_714 4296-0578 26.1 µM -0.145383990417945 0.447602204664306 no 1872 0.44220385208072 2684 1589775 SGTC_747 3448-8087 38.7 µM -0.146506727102412 0.447161607739734 no 1873 0.441760689880418 2719 5168703 SGTC_1713 st033146 12.748 µM -0.146663902916827 0.447099932233938 no 1874 0.441698655865994 2756 674619 SGTC_1626 st003712 1.76 µM -0.147117006853551 0.446922142232162 no 1875 0.44151983320472 2806 24207035 SGTC_2976 9009005 19.48 µM -0.148169550080125 0.446509184043614 no 1876 0.441104481024289 2842 2993148 SGTC_2394 5221648 200 µM -0.148906873027091 0.446219934912506 no 1877 0.440813558895709 2785 788586 SGTC_448 monastrol 171 µM -0.149810021552815 0.445865672012957 no 1878 0.44045725126786 2699 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1845 st056753 3.01 µM -0.150247026978511 0.445694270732326 no 1879 0.440284862398931 2630 5375839 SGTC_713 1488-1073 324 µM -0.151312740374377 0.445276321649697 no 1880 0.439864509815674 2655 3312542 SGTC_1218 1348-1416 30.7 µM -0.151357333964607 0.445258834358221 no 1881 0.439846922104105 2659 6787668 SGTC_692 k241-0027 77.8 µM -0.151396758159737 0.445243374323899 no 1882 0.43983137330078 2810 3600480 SGTC_1817 st052116 64.4 µM -0.151806192203083 0.445082821392533 no 1883 0.439669899035744 2802 4361398 SGTC_3208 9114115 49.47 µM -0.151985550223867 0.445012491884248 no 1884 0.439599166248858 2759 650895 SGTC_22 0964-0034 14.468 µM -0.152063681908545 0.444981855585435 no 1885 0.439568354336105 2708 138402 SGTC_3125 9127534 49.47 µM -0.152315863896894 0.444882974478062 no 1886 0.43946890666338 2641 1639235 SGTC_3124 9127567 49.47 µM -0.152356075494001 0.444867207740049 no 1887 0.439453049619948 2834 17592030 SGTC_1998 st075797 76.8 µM -0.15396583051493 0.444236103872153 no 1888 0.438818338790751 2634 24208315 SGTC_3019 9081971 49.47 µM -0.154298056215232 0.444105872453527 no 1889 0.438687364939769 2815 16451803 SGTC_3030 9087619 49.47 µM -0.154392817950302 0.444068727260135 no 1890 0.438650008104573 2705 25236973 SGTC_1402 3909-7673 35.9 µM -0.155916560223599 0.443471510598209 no 1891 0.438049395889449 2651 5328014 SGTC_659 k018-0002 107 µM -0.156642081532339 0.443187194276734 no 1892 0.43776346781955 2760 6797879 YHR007C ERG11 SGTC_2097 5376186 200 µM -0.157037349302218 0.44303230956955 no 1893 0.437607706388908 2752 742755 SGTC_3331 9141060 1.957 µM -0.157406549309999 0.442887647312947 no 1894 0.437462226098796 2695 4906567 YPR165W RHO1 SGTC_5 0352-0601 109.883 µM -0.15800491277655 0.442653208972923 no 1895 0.437226463755819 2714 762456 SGTC_2050 5263056 171 µM -0.158686061053449 0.442386360050755 no 1896 0.436958110342592 2789 763468 YGL055W OLE1 SGTC_1895 st058434 18.3 µM -0.158873414584077 0.442312966384721 no 1897 0.436884303360683 2841 5393175 SGTC_578 3460-0051 92 µM -0.159906235233531 0.441908405969187 no 1898 0.436477468360483 2679 2876744 SGTC_2215 7188065 200 µM -0.160073245129585 0.441842993134067 no 1899 0.436411688338453 2816 940217 SGTC_2115 tiliquinol 12.7705 µM -0.161628913350773 0.441233760342092 no 1900 0.435799043558289 2810 71208 A bioactive hydroxyquinoline. SGTC_487 nimodipine 119 µM -0.162475380160463 0.440902324233752 no 1901 0.435465757224905 2733 4497 L-type voltage-gated calcium channels inhibitor SGTC_2130 NSC 7 2.4545 µM -0.163583810851708 0.44046837816121 no 1902 0.435029395041347 2781 21448 SGTC_547 1120-0019 610 nM -0.16425448427639 0.440205846944018 no 1903 0.434765405621989 2671 3676939 SGTC_1136 pergolide 1.05886 µM -0.164346340294288 0.440169892483254 no 1904 0.43472925166214 2710 47811 A dopamine receptor agonist. SGTC_2581 avocatin a 64 µM -0.164423736025751 0.440139598478822 no 1905 0.434698789605146 2762 6710728 A skin care supplement. SGTC_1783 st039459 87.517 µM -0.165677846937214 0.439648767124794 no 1906 0.434205240338697 2933 729761 SGTC_1747 st037496 66.6 µM -0.166340465907821 0.439389470074689 no 1907 0.433944511209562 2715 723305 SGTC_94 0334-0113 514.748 µM -0.166805570676081 0.439207480103493 no 1908 0.433761517667834 2725 6795178 SGTC_579 4491-1009 110 µM -0.167153506549282 0.43907134532841 no 1909 0.433624633022112 2710 1271041 SGTC_2237 6667747 47.222 µM -0.167315454214799 0.439007983496778 no 1910 0.433560922418484 2735 729940 YDL015C TSC13 SGTC_3179 9107801 49.47 µM -0.167809901846014 0.438814541125463 no 1911 0.433366416211645 2732 4818259 SGTC_1123 mangostin 811.285 nM -0.167828290240397 0.438807347329456 no 1912 0.433359182881235 2798 5281650 An antioxidant. SGTC_2411 st077133 39.94 µM -0.171524467819047 0.437361764735575 no 1913 0.431905696493307 3023 1403142 YNL221C POP1 SGTC_1040 k898-0338 155 µM -0.172354862544991 0.437037109955 no 1914 0.43157927777283 2861 20969351 SGTC_1507 4075-3230 155 µM -0.172372084434663 0.437030377257143 no 1915 0.431572508537618 2668 659771 SGTC_1307 1187-1599 12.2 µM -0.172510315809712 0.436976337966463 no 1916 0.431518176047417 2705 1538471 SGTC_3238 9133470 49.47 µM -0.172512588056781 0.436975449678531 no 1917 0.431517282940872 2849 3534688 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.174457994438376 0.43621505039611 no 1918 0.430752770031323 2861 6728940 SGTC_2265 7929201 200 µM -0.17517340329482 0.435935478287878 no 1919 0.430471691138222 2689 1265108 SGTC_1630 st005209 31.3 µM -0.176735461883932 0.435325158342975 no 1920 0.429858092380283 2704 3367314 SGTC_873 0591-4978 488 µM -0.177758464954643 0.434925538930518 no 1921 0.429456333965725 2937 3305145 SGTC_3212 9128307 49.47 µM -0.179797730702766 0.434129131821761 no 1922 0.428655682611172 2724 27243542 SGTC_831 k061-1017 217 µM -0.179880023497012 0.434096999095275 no 1923 0.428623379162169 2783 1240153 SGTC_1263 0774-1208 64.8 µM -0.180427825746477 0.43388311079615 no 1924 0.4284083554955 2834 906585 SGTC_2324 6149169 200 µM -0.180860733242653 0.433714096615243 no 1925 0.428238445416191 2807 2888231 SGTC_2464 5717415 7.67 µM -0.181447961753123 0.433484852356926 no 1926 0.428007987784875 2730 5285744 SGTC_2258 7960471 200 µM -0.181642434529178 0.433408938343153 no 1927 0.427931672417889 2779 2974708 SGTC_3354 9151612 71.43 µM -0.185200787508181 0.432020343141068 no 1928 0.426535775717516 2857 27261949 SGTC_3070 9117005 49.47 µM -0.185251303187848 0.432000636138528 no 1929 0.426515965637511 2726 8779016 SGTC_273 hydroxyurea 18.1 mM -0.186396945445597 0.431553747662217 no 1930 0.426066743818856 2727 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2180 6301957 200 µM -0.187265887204938 0.431214852014221 no 1931 0.425726083942299 2783 845462 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.188315433397345 0.430805586433825 no 1932 0.425314693844056 2880 61125 An anti-inflammatory. SGTC_950 1165-0508 94.1 µM -0.189134386790947 0.430486291009724 no 1933 0.424993745538024 2828 6148369 SGTC_2953 9074162 66.49 µM -0.19024835227722 0.430052048578463 no 1934 0.424557261656781 2845 16451992 SGTC_2651 TUB2.036 5 µM -0.190591505524235 0.429918298705611 no 1935 0.424422822904884 2826 15992207 YFL037W TUB2 SGTC_348 k064-0012 10.7 µM -0.191039403347614 0.429743734935967 no 1936 0.42424736111048 2707 5066323 SGTC_970 1315-0089 19.5 µM -0.191779464277798 0.429455333580651 no 1937 0.423957478752068 2756 6811083 YLR033W RSC58 SGTC_2860 9025725 38.96 µM -0.192493623444451 0.429177061820555 no 1938 0.423677781135002 2736 40546248 SGTC_1060 3448-7350 82 µM -0.192825343257883 0.429047819323682 no 1939 0.4235478774487 2858 570178 SGTC_97 0535-0701 19.132 µM -0.195008843660252 0.428197288673317 no 1940 0.422693012148203 2763 2832013 YGL099W LSG1 SGTC_2808 7946468 45.46 µM -0.196016082107704 0.427805055039434 no 1941 0.422298789234875 2831 2970879 SGTC_2998 9066762 71.4286 µM -0.196062943293811 0.4277868083301 no 1942 0.42228045013353 2898 4945196 SGTC_353 1988-1175 58.3 µM -0.196158478464875 0.427749609526059 no 1943 0.422243063014877 2678 2788357 SGTC_2518 prenyletin 46.28 µM -0.198292113823286 0.426918997725063 no 1944 0.421408260722945 2848 3873459 A coumarin with calcium channel inhibitory activity. SGTC_602 3130-1533 38.1 µM -0.199140515997044 0.426588809513364 no 1945 0.421076414347934 2884 720941 SGTC_1356 1502-0781 85.8 µM -0.199508204625609 0.426445725360575 no 1946 0.420932612999404 2747 567702 SGTC_2211 7117706 200 µM -0.199887493606295 0.426298137133463 no 1947 0.420784285859062 2836 822771 SGTC_2616 abietic acid 100 µM -0.200502886090968 0.426058698713904 no 1948 0.42054365052633 2832 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2263 7948595 193.29 µM -0.200553789129335 0.426038894454019 no 1949 0.420523747371084 2755 2971371 SGTC_2568 diosmetin 100 µM -0.200687786525743 0.42598676251956 no 1950 0.420471355183631 2821 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_957 1187-1561 14.1 µM -0.200726467561522 0.425971713831726 no 1951 0.420456231390017 2740 1538454 SGTC_2728 chlorpromazine 9.18 µM -0.201731176902015 0.425580873885391 no 1952 0.420063444000371 2730 2726 A thorazine and dopamine antagonist. SGTC_1403 3909-7815 62.9 µM -0.202157494714542 0.425415054926775 no 1953 0.419896800665519 2737 6615483 SGTC_2740 felodipine 17.08 µM -0.203673283912176 0.424825586344831 no 1954 0.419304410457905 2869 3333 L-type calcium channel blocker SGTC_565 1418-0001 44.5 µM -0.204191036133759 0.424624278404752 no 1955 0.419102107961491 2937 2862145 SGTC_3120 9124077 49.47 µM -0.204897665552522 0.424349564600151 no 1956 0.418826039572992 2719 18774327 YGL155W CDC43 SGTC_1094 duloxetine 25.4 µM -0.205667996643293 0.424050127593377 no 1957 0.418525129537946 2757 60834 A selective serotonin reuptake inhibitor. SGTC_354 2783-3500 4.88 µM -0.205896782355654 0.423961204257463 no 1958 0.418435769455233 2792 6740761 SGTC_1081 sertraline 6 µM -0.206256095990424 0.423821555769528 no 1959 0.418295435727733 2889 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_477 mead ethanolamide 10 µM -0.206592077703417 0.423690983967942 no 1960 0.418164223936675 2750 16061185 SGTC_853 0419-0306 21 µM -0.206994445648728 0.423534623663295 no 1961 0.418007098147318 2775 762713 SGTC_2096 5468907 200 µM -0.207446478769303 0.423358977818678 no 1962 0.417830593580313 2922 759785 SGTC_1333 1482-0047 286 µM -0.208096437250525 0.423106451108809 no 1963 0.417576834466459 2867 3811116 SGTC_1825 st052143 62.6 µM -0.208210535242525 0.423062124163559 no 1964 0.417532291458765 2937 674173 SGTC_295 k015-0027 31 µM -0.212063818760389 0.421565703095078 no 1965 0.416028623084351 2872 3887424 SGTC_1019 4262-0212 3.4 µM -0.212565284586456 0.421371041835361 no 1966 0.415833025739328 2860 4677213 SGTC_722 3534-0461 190 µM -0.21423044126513 0.420724791928913 no 1967 0.415183679200801 2829 658262 SGTC_2416 tofa 880 nM -0.214476374705134 0.420629362837515 no 1968 0.415087794282673 2806 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2921 7974240 10.71 µM -0.216638639569374 0.419790544648896 no 1969 0.414244985366424 2920 2979074 YDR527W RBA50 SGTC_1956 st077085 54 µM -0.216832729801693 0.419715268018305 no 1970 0.414169352006645 2830 24208685 SGTC_635 k038-0028 24.7 µM -0.217838566336673 0.419325207997566 no 1971 0.413777447234511 2826 4035102 SGTC_2222 6885208 172.143 µM -0.218493983830085 0.419071081931495 no 1972 0.413522122650282 2824 609514 SGTC_1042 0350-0096 82 µM -0.218885058713595 0.418919465920477 no 1973 0.413369792841182 2760 3122515 SGTC_323 4013-0906 34.3 µM -0.219188755199805 0.41880173398771 no 1974 0.413251507283442 2896 2910086 SGTC_3149 9097855 49.47 µM -0.219506136806049 0.41867870460925 no 1975 0.41312789997577 2956 25236625 YMR079W SEC14 SGTC_56 0957-0365 83.25 µM -0.219635392202844 0.418628602499792 no 1976 0.413077562689862 2843 6752360 SGTC_2037 5169046 200 µM -0.219749925476831 0.418584208097652 no 1977 0.413032959988877 2901 5718022 SGTC_1735 st034310 56.75 µM -0.219908743737844 0.418522650045884 no 1978 0.412971113239952 3000 871153 SGTC_2992 9074591 71.4286 µM -0.219991732648777 0.418490484288625 no 1979 0.412938796692355 2875 17741321 SGTC_2627 acetyl isogambogic acid 100 µM -0.220011261856854 0.418482915022012 no 1980 0.412931191947828 2892 6857789 A caspase activator and apoptosis inducer. SGTC_3117 9124945 49.47 µM -0.220054177436709 0.418466281608439 no 1981 0.412914480580024 2760 17592065 SGTC_1046 2001-0062 216 µM -0.220099234148492 0.418448818482202 no 1982 0.412896935623227 2776 739778 SGTC_3283 9109332 35.8195 µM -0.220235461042825 0.418396020501558 no 1983 0.412843890312278 2764 17027281 SGTC_1375 2910-0797 186 µM -0.2204069384594 0.418329562430877 no 1984 0.412777121083575 2866 742508 SGTC_801 0866-0028 10.1 µM -0.220685887481589 0.418221457469239 no 1985 0.412668510359335 2777 6849771 SGTC_586 0957-0265 8.15 µM -0.221047834903957 0.4180811962022 no 1986 0.412527593602974 2837 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1335 1486-0900 202 µM -0.221270145054164 0.41799505210347 no 1987 0.412441047323361 2768 X1335 SGTC_3201 9113999 49.47 µM -0.221362486771424 0.417959271294726 no 1988 0.412405099554331 2995 16649224 SGTC_2816 7982706 58.44 µM -0.224228068212616 0.416849247285619 no 1989 0.411289922093789 2911 2981853 SGTC_749 1000-0129 128 µM -0.22455993645746 0.416720736012472 no 1990 0.411160817463184 2967 708470 SGTC_1826 st055655 41.6 µM -0.224908751605533 0.41658567188427 no 1991 0.411025130455478 2864 676168 SGTC_1740 st038286 13.222 µM -0.226053429543579 0.41614251232164 no 1992 0.410579932443702 3011 716786 SGTC_1389 3405-0187 19 µM -0.227009066028074 0.415772621359783 no 1993 0.410208346261376 2848 799890 SGTC_3167 9103034 49.47 µM -0.227658571085555 0.415521264932633 no 1994 0.409955841087171 2781 5127859 SGTC_89 0302-0250 142.109 µM -0.229278120435466 0.41489465515591 no 1995 0.409326378964507 2787 4203518 YLR208W SEC13 SGTC_1355 1499-0035 1.68 µM -0.229930845078581 0.414642174628809 no 1996 0.409072753735442 2805 1548538 SGTC_1668 st014914 51.6 µM -0.230415828684297 0.414454600866126 no 1997 0.408884331257871 2831 2839556 SGTC_2067 5224629 34.075 µM -0.230749753560644 0.414325462382655 no 1998 0.408754609310015 2962 2835000 SGTC_3056 9094900 49.47 µM -0.230822302610842 0.414297406774316 no 1999 0.408726427034323 2853 25236784 SGTC_2351 9026858 72.31 µM -0.231286665070429 0.414117842473487 no 2000 0.408546052798367 2794 1409300 SGTC_3274 9138298 49.47 µM -0.23177248868662 0.413929998574503 no 2001 0.408357363051857 2790 17015756 SGTC_855 0428-0020 25 µM -0.233037706015141 0.413440894296833 no 2002 0.407866063254521 2836 6812414 SGTC_443 clozapine 122 µM -0.234750725646307 0.412778893940437 no 2003 0.407201107131883 2796 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_257 daunorubicin 18.5 µM -0.235788916604332 0.412377803238169 no 2004 0.406798234487106 2927 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2564 betulinic acid 100 µM -0.235958537135819 0.412312281378365 no 2005 0.406732422168578 3104 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2192 5915882 198.485 µM -0.236056915847378 0.412274280281606 no 2006 0.406694252694905 2813 2876149 SGTC_759 3486-0358 89.3 µM -0.236113862199166 0.412252283786436 no 2007 0.406672158764265 2989 875103 SGTC_2305 7443522 69.23 µM -0.236609115022761 0.412060995605148 no 2008 0.406480024106752 2826 5415886 SGTC_515 4092-1064 102 µM -0.237582469894777 0.411685104538783 no 2009 0.406102474126755 3061 717353 SGTC_712 r015-0009 80.6 µM -0.238401516276572 0.41136886723246 no 2010 0.405784845753916 2942 6813872 YLR060W FRS1 SGTC_3040 9091894 49.47 µM -0.238727393091353 0.411243060802177 no 2011 0.405658487089742 2828 25236966 SGTC_2834 9001755 58.44 µM -0.241968781357806 0.40999220499376 no 2012 0.404402176693691 2907 2989575 SGTC_3353 9151644 39.2805 µM -0.242270361610914 0.409875871145112 no 2013 0.404285338889974 2957 4909158 SGTC_562 3772-2733 112 µM -0.242435967894966 0.409811992297538 no 2014 0.404221183563068 2942 2876874 YIL048W NEO1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.243554798245564 0.409380491799446 no 2015 0.403787819950112 2815 803109 SGTC_1922 5578187 25 µM -0.244764859531374 0.408913929733693 no 2016 0.403319252207864 3068 1350412 SGTC_687 k029-0044 34.9 µM -0.24477957427372 0.40890825697861 no 2017 0.403313555122983 2979 5829338 SGTC_2951 9072950 58.06 µM -0.2450074000122 0.408820429156076 no 2018 0.40322535079018 2838 16488155 SGTC_990 3985-0011 41.3 µM -0.24645032725418 0.408264280865267 no 2019 0.402666825899679 2898 5399565 YGL099W LSG1 SGTC_2915 7971052 15.16 µM -0.247526815549721 0.407849489606656 no 2020 0.402250270615341 2845 5741558 SGTC_1959 st077091 55.8 µM -0.247535033626682 0.407846323423091 no 2021 0.40224709099461 2808 821356 YKL052C ASK1 SGTC_644 1498-1197 63.3 µM -0.247992935227606 0.407669916907398 no 2022 0.402069936486584 2952 6741615 SGTC_1305 1181-0477 144 µM -0.25249485260603 0.4059365560969 no 2023 0.400329296137726 2987 6252086 SGTC_1699 st031318 29.054 µM -0.25278800749768 0.405823747007316 no 2024 0.400216017712626 2957 5340658 SGTC_2914 7968218 45.32 µM -0.252936104417308 0.405766760725567 no 2025 0.40015879454882 2948 2977111 SGTC_2506 ethyl hematommate 54.16 µM -0.253059266382808 0.405719370697102 no 2026 0.400111207633575 2913 3940691 An allergen. SGTC_1182 1222-0449 220 µM -0.253594613904697 0.405513396753562 no 2027 0.399904379061494 2918 658318 SGTC_3099 9120367 49.47 µM -0.255203133586854 0.404894679467892 no 2028 0.3992831054672 2842 24824940 SGTC_360 0957-0399 1.01 µM -0.255341653789876 0.404841408748882 no 2029 0.399229615417283 3004 6752301 YPR165W RHO1 SGTC_902 1120-0002 2.07 µM -0.255718581939302 0.404696462408894 no 2030 0.399084072904953 2839 3280475 SGTC_431 k089-0097 107 µM -0.257647464345031 0.403954922831274 no 2031 0.398339497384654 2978 5499420 SGTC_361 000s-0510 1.45 µM -0.258384824398675 0.403671543133413 no 2032 0.398054963715176 2950 660 SGTC_1530 rhein 70.4 µM -0.259048272728144 0.40341661214359 no 2033 0.39779899754232 2849 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1109 tnp00067 928.257 nM -0.26094738691206 0.402687101946797 no 2034 0.397066540474733 2895 676295 SGTC_1557 sumaresinolic acid 42.3 µM -0.261854378752413 0.402338816860937 no 2035 0.396716856548747 2866 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_910 3454-3003 490 µM -0.261925034200944 0.402311688402488 no 2036 0.396689619351535 2973 820824 SGTC_2082 5219693 150 µM -0.263544851864246 0.401689881844876 no 2037 0.396065329099168 2862 2834649 SGTC_3021 9087658 49.47 µM -0.263757144864342 0.401608406401701 no 2038 0.395983529451449 2920 25237042 SGTC_931 2812-0076 566 µM -0.264868314093025 0.401182023170227 no 2039 0.395555454239692 2845 3450959 SGTC_846 0335-0850 148 µM -0.265895809218426 0.400787852459592 no 2040 0.395159726357524 2940 6819598 SGTC_2488 5268135 45.7 µM -0.266002144595751 0.400747065528355 no 2041 0.395118778680825 3013 1270356 YLR208W SEC13 SGTC_3037 9091026 49.47 µM -0.266238237840676 0.400656511398568 no 2042 0.395027867925085 2970 25236398 YIL048W NEO1 SGTC_2592 piperlongumine 83.33 µM -0.266910045588396 0.400398867151598 no 2043 0.394769210947584 2956 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2636 apigenin dimethyl ether 100 µM -0.267611204795257 0.400130012575473 no 2044 0.394499302639385 3020 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2229 7354935 190 µM -0.267715014253442 0.40009021158646 no 2045 0.394459345922827 2965 318112 SGTC_2693 st077581 40.7 µM -0.269827679689286 0.399280432668843 no 2046 0.39364641353298 2995 25238761 SGTC_2455 5377712 9.75 µM -0.269961843993351 0.399229022447535 no 2047 0.393594804068622 2967 2243908 SGTC_1730 st033808 45.1 µM -0.272086385200707 0.398415156162529 no 2048 0.392777798906832 2876 1045166 SGTC_260 nsc-65238 3.989 µM -0.273076076083541 0.398036177331396 no 2049 0.392397368287392 3007 3246252 SGTC_3146 9095609 49.47 µM -0.273732578494709 0.397784838220567 no 2050 0.392145069801707 2955 17173999 SGTC_1686 st019653 115.5 µM -0.273755430787983 0.397776090082249 no 2051 0.392136288320892 3026 97252 SGTC_270 tamoxifen 5.46 µM -0.27524204540675 0.397207106390054 no 2052 0.3915651431889 3093 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_232 clozapine 119 µM -0.275297287543562 0.397185967339967 no 2053 0.391543924108788 2868 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2836 9010338 19.48 µM -0.275560811421642 0.397085131002172 no 2054 0.391442706284948 2906 2994051 SGTC_875 0709-0210 25.7 µM -0.275706228006615 0.397029490883708 no 2055 0.391386855857977 2992 6251364 SGTC_2251 lansoprazole 556 µM -0.276032936827328 0.396904491347443 no 2056 0.391261384342173 2873 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2289 7946404 165.07 µM -0.276084827476155 0.396884638841825 no 2057 0.391241456939352 2877 1246120 YPR165W RHO1 SGTC_984 1492-0255 2.91 µM -0.276931875672338 0.396560610005898 no 2058 0.390916208083319 3012 1585198 SGTC_3029 9088683 49.47 µM -0.277491701858985 0.396346493932049 no 2059 0.39070128835078 3042 25236615 SGTC_1854 st056233 32.9 µM -0.278498868386592 0.39596136286255 no 2060 0.390314716795449 2991 5393174 SGTC_489 paxilline 115 µM -0.279519292247999 0.395571265859964 no 2061 0.389923167366132 2967 105008 A toxic potassium channel blocker. SGTC_1945 st075991 56.6 µM -0.279912604366139 0.39542093479903 no 2062 0.389772278369417 2951 1084980 SGTC_1198 1612-1005 86.7 µM -0.2838502632643 0.393916751017888 no 2063 0.388262566739323 3104 6998509 SGTC_2185 6113692 200 µM -0.284028316520523 0.393848771960533 no 2064 0.38819434021539 3038 874150 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.284819384879154 0.393546788642533 no 2065 0.387891260043575 2924 688801 SGTC_2965 9082772 38.63 µM -0.285328982875891 0.393352288027109 no 2066 0.387696055102821 3095 16459634 SGTC_1923 st058458 19.1 µM -0.28638286962025 0.392950130698209 no 2067 0.387292446788296 3151 3534982 SGTC_1212 0520-0165 585 µM -0.287295179266385 0.392602090629876 no 2068 0.386943156768736 3317 5403258 SGTC_2820 7989630 71.43 µM -0.288512166316707 0.392137951865927 no 2069 0.386477359450515 2979 2984098 SGTC_2238 6671620 73.2395 µM -0.288634148419987 0.392091438355092 no 2070 0.386430680255048 2844 729941 SGTC_2197 6588183 93.1375 µM -0.288725453539189 0.392056623423581 no 2071 0.386395741372965 2925 884136 SGTC_1432 4049-0298 68.4 µM -0.288934321001316 0.391976984847847 no 2072 0.386315819464676 3022 741646 SGTC_2317 5986382 200 µM -0.289606017340433 0.391720906048263 no 2073 0.386058831514771 2983 877883 SGTC_3195 9113082 49.47 µM -0.290072006752096 0.391543278904195 no 2074 0.385880575456864 2995 17018038 SGTC_2674 ligustilide 100 µM -0.291122685086485 0.391142861423842 no 2075 0.385478745388688 3010 5319022 A signalling regulator. SGTC_1994 st072947 40.9 µM -0.291626243760547 0.390950994177124 no 2076 0.38528620380383 3032 5286565 YDL195W SEC31 SGTC_2997 9067075 71.4286 µM -0.292399934528127 0.39065625222219 no 2077 0.384990429140897 3026 27209819 SGTC_2343 7990716 14.84 µM -0.292887250796839 0.390470638513532 no 2078 0.384804167071687 2907 6456862 SGTC_1886 st057356 49.9 µM -0.294385863186046 0.389899989182354 no 2079 0.384231534054673 2910 24207747 SGTC_3337 9144342 33.5465 µM -0.294768923377054 0.389754163572197 no 2080 0.384085203860156 3010 17682949 SGTC_3163 9099914 49.47 µM -0.296680342806047 0.389026745450412 no 2081 0.383355282939689 3013 16268368 SGTC_445 e6 berbamine 66 µM -0.299028112919058 0.388133800099917 no 2082 0.382459297685417 3039 6610268 A calcium/calmodulin antagonist. SGTC_1114 scopoletin 1.73284 µM -0.300078451228049 0.387734507983235 no 2083 0.382058657820683 3068 5280460 A coumarin with genotoxic properties. SGTC_2475 5812728 15.03 µM -0.300530933845009 0.387562530682841 no 2084 0.381886102246856 2910 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1088 bifonazole 369 nM -0.300785516550989 0.387465779872658 no 2085 0.381789026697205 2988 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1759 st043059 70 µM -0.302738149800504 0.386723940056677 no 2086 0.381044710943166 2928 669426 SGTC_3134 9127454 49.47 µM -0.302990912986557 0.386627941049601 no 2087 0.38094839334656 3029 24262820 SGTC_3219 9131112 49.47 µM -0.303621112203365 0.386388622733555 no 2088 0.380708282621904 3045 17612988 YMR079W SEC14 SGTC_96 0929-0093 37.281 µM -0.304512931415495 0.386050028016713 no 2089 0.380368571201089 2938 6991579 SGTC_669 0108-0021 26.2 µM -0.304927179238803 0.385892781106249 no 2090 0.380210807443966 3166 17201 SGTC_2319 6033012 152.6 µM -0.305972173972291 0.385496188398775 no 2091 0.379812916165719 2959 847246 SGTC_2104 5389443 200 µM -0.307090287950967 0.385071978288044 no 2092 0.379387324941058 3118 2244536 SGTC_338 4055-0136 114 µM -0.309337236140901 0.384219907127592 no 2093 0.378532504335094 2941 2900563 SGTC_786 4544-0069 423 µM -0.309766690146976 0.384057116269682 no 2094 0.378369191940238 3059 748821 YLR208W SEC13 SGTC_1062 mesoridazine 14.2 µM -0.309801752228782 0.384043826374579 no 2095 0.378355859521199 2935 4078 A neuroleptic. SGTC_868 0527-0199 213 µM -0.313315885257032 0.382712527162951 no 2096 0.377020341297441 2979 2849450 SGTC_1271 0832-2808 169 µM -0.313731888798562 0.382555019140513 no 2097 0.376862339466697 3106 3663794 SGTC_1396 3511-0007 98.6 µM -0.313778510866824 0.382537368217746 no 2098 0.37684463327661 3063 X1396 SGTC_84 0443-0269 128.823 µM -0.314536620086108 0.382250385463143 no 2099 0.37655675394028 3038 6150058 SGTC_11 0438-0307 1.3 µM -0.316216901086708 0.38161454468444 no 2100 0.375918940114926 3050 4011476 SGTC_1878 temozolomide 1 mM -0.317592108561844 0.381094385331119 no 2101 0.375397180458763 3067 5394 DNA alkylating agent. SGTC_1304 1165-0502 251 µM -0.318413479917145 0.380783811688634 no 2102 0.375085657237871 2983 767425 SGTC_2830 7992007 71.43 µM -0.320291440767532 0.380074013492078 no 2103 0.374373705481662 2814 1952075 SGTC_1903 st060211 78.3 µM -0.323398762425789 0.378900451068997 no 2104 0.373196633335025 3139 688960 SGTC_978 1416-0512 87.4 µM -0.324484475233402 0.378490665257777 no 2105 0.372785636977315 3046 6814003 SGTC_1190 1486-1332 13 µM -0.325569093513524 0.378081428949072 no 2106 0.37237519950102 3035 4150046 SGTC_2734 clemastine 41.6 µM -0.325671602964424 0.378042758270355 no 2107 0.372336415719428 3000 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2205 7238770 200 µM -0.326366744620008 0.377780555196497 no 2108 0.372073447590056 3106 279867 SGTC_2031 5180455 200 µM -0.326506403112287 0.377727883677161 no 2109 0.372020622770406 2983 29949 SGTC_2745 rifampicin 24.3 µM -0.327132023738513 0.37749196182446 no 2110 0.371784015847258 3027 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2365 9042475 200 µM -0.328878312061381 0.37683367770915 no 2111 0.371123833873748 3107 6464479 SGTC_1928 4'-methoxychalcone 40.3 µM -0.331168827000406 0.375970783735708 no 2112 0.370258482679667 3196 641818 SGTC_2158 5657123 3.6195 µM -0.33149614793935 0.375847524305887 no 2113 0.370134875082557 2975 2858827 SGTC_1720 st037298 9.481 µM -0.331615647615639 0.375802527401441 no 2114 0.37008975125329 3076 597396 SGTC_3321 9137793 26.8275 µM -0.331877154101733 0.375704064555647 no 2115 0.369991010998461 3043 4904192 SGTC_1997 st073024 93.8 µM -0.332556844592352 0.375448184263108 no 2116 0.369734411905834 3127 686268 SGTC_1975 st070967 30.8 µM -0.333895239689552 0.374944484391025 no 2117 0.369229306016395 3163 261391 SGTC_858 0438-0351 2.77 µM -0.334445253704829 0.374737550490224 no 2118 0.369021797923891 3030 2799119 SGTC_2553 4-methylesculetin 85.09 µM -0.334748363800198 0.374623525616233 no 2119 0.36890745751502 3048 5319502 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.334846036404878 0.374586785174699 no 2120 0.368870615533353 3032 6857784 SGTC_561 1550-0330 72.9 µM -0.335739223552852 0.374250857528542 no 2121 0.368533762411701 2998 6812934 SGTC_2345 9052315 157.45 µM -0.335859617605469 0.374205584625381 no 2122 0.368488365186892 3081 6469265 SGTC_2189 6047310 154.431 µM -0.336009134698463 0.374149362727599 no 2123 0.368431989034784 2975 711535 SGTC_2400 5203494 178.7 µM -0.336027868863367 0.374142318435385 no 2124 0.368424925425809 2984 6777674 SGTC_3313 9133968 57.047 µM -0.336727355532377 0.373879332350895 no 2125 0.368161219850498 2971 1494643 SGTC_1717 st033143 58.0435 µM -0.33675010602046 0.373870779832242 no 2126 0.368152643987924 3166 674616 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.337447716240585 0.373608559604876 no 2127 0.367889709702993 3097 1377 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.339273338885938 0.372922615182431 no 2128 0.367201912656479 3016 2724278 An inhibitor of dopamine biosynthesis. SGTC_3076 9116187 49.47 µM -0.339874883285117 0.372696683940034 no 2129 0.366975376058629 3098 27241210 SGTC_164 4100-3994 89.624 µM -0.34029172377218 0.372540150455264 no 2130 0.366818424571674 3125 4615967 SGTC_2667 digitoxin 100 µM -0.340655914879674 0.372403405290039 no 2131 0.366681315191661 3082 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_934 2950-0684 338 µM -0.34215926967712 0.371839101459967 no 2132 0.366115517695825 3209 1121253 SGTC_863 0466-0191 129 µM -0.343332443021022 0.371398926663218 no 2133 0.36567418823591 3137 765160 YPR165W RHO1 SGTC_1127 asiatic acid 681.4 nM -0.34359870358112 0.371299049054652 no 2134 0.365574049904645 2996 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2917 7979103 53.79 µM -0.343788953076832 0.371227689438568 no 2135 0.365502504298988 3156 2980565 SGTC_1523 st012844 44.7 µM -0.343937592012834 0.371171940374134 no 2136 0.365446610099567 3131 4274103 SGTC_2936 9038235 15.59 µM -0.345040128217982 0.370758503564874 no 2137 0.365032101558239 2968 4749415 SGTC_3221 9128209 49.47 µM -0.345976615432287 0.370407450125231 no 2138 0.364680144460669 3044 16460723 SGTC_1433 4060-0023 7.6 µM -0.348022789348846 0.369640793126102 no 2139 0.363911534326923 3138 3840627 SGTC_2900 5328528 85.29 µM -0.34818212298514 0.369581115965227 no 2140 0.363851706304648 3010 795359 SGTC_1076 itraconazole 331 nM -0.349944165058038 0.368921366732743 no 2141 0.363190300552083 3063 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2413 inermin 26.06 µM -0.352701405461104 0.367889767537623 no 2142 0.362156152794404 3293 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2470 5664817 21.68 µM -0.352781307889682 0.36785988685129 no 2143 0.362126199045712 3010 2859561 SGTC_2374 9071832 200 µM -0.356538807251243 0.366455620685995 no 2144 0.360718547497669 3015 17381698 SGTC_930 2810-3379 265 µM -0.356781010225767 0.366365164796435 no 2145 0.360627876782273 3239 1015764 SGTC_2520 obtusaquinone 4.71 µM -0.357359764999316 0.366149046501379 no 2146 0.360411246815194 3203 5967872 SGTC_1497 4476-2978 41.3 µM -0.357517366341901 0.366090202444762 no 2147 0.360352263831042 3112 1528379 SGTC_2256 7954252 200 µM -0.357627312889241 0.366049153257904 no 2148 0.360311117827969 3106 2972920 SGTC_1915 st067105 30.6 µM -0.357894778421173 0.365949299838587 no 2149 0.360211029238676 3050 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1178 0988-0033 191 µM -0.358472929683195 0.365733488553125 no 2150 0.359994711324297 3164 5392207 SGTC_3 0833-0587 95.581 µM -0.362722835642618 0.36414839921115 no 2151 0.358405969732628 3088 5382644 SGTC_138 0850-0259 40.9225 µM -0.362873386229075 0.364092290702743 no 2152 0.358349734167867 3120 6813004 SGTC_2945 9067681 61.76 µM -0.363555229888131 0.363838211738223 no 2153 0.358095081755683 3068 16456930 SGTC_450 aminopyrene 156 nM -0.364879757603568 0.363344817220446 no 2154 0.357600582598975 3161 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2893 9048488 25.97 µM -0.365653990063677 0.363056515886648 no 2155 0.357311641266656 3077 6467338 SGTC_2950 9072895 21.46 µM -0.365947774436664 0.3629471395469 no 2156 0.357202023179029 3180 17332245 SGTC_767 0929-0023 86 µM -0.36649108615439 0.36274489328053 no 2157 0.356999331431155 3126 1204563 SGTC_3336 9143619 71.43 µM -0.368059714002181 0.362161190960921 no 2158 0.356414354564514 3180 45595730 SGTC_2279 7948423 32.93 µM -0.369539121215897 0.361610982066246 no 2159 0.355862959450198 3229 1247112 SGTC_3330 9141424 71.43 µM -0.369984514167864 0.361445391167151 no 2160 0.355697014436717 3183 27261020 SGTC_1315 1237-0019 3.69 µM -0.370953977492153 0.361085047952093 no 2161 0.355335905258114 3195 825140 SGTC_2984 9022109 38.96 µM -0.371558803478823 0.360860300471831 no 2162 0.355110683256132 3180 6459207 SGTC_1679 SEC14.276 6.7 µM -0.37244376859889 0.360531542585906 no 2163 0.35478123569577 3175 1005053 YMR079W SEC14 SGTC_2648 atorvastatin 78.68 µM -0.373163353987937 0.360264297988371 no 2164 0.354513434366165 3155 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1250 0485-0349 40.2 µM -0.374302205240712 0.359841483087956 no 2165 0.354089745794161 3075 6842794 YDL195W SEC31 SGTC_1670 st016595 4.04 µM -0.374314735554283 0.359836831981606 no 2166 0.354085085125881 3135 597879 SGTC_413 propylparaben 100 µM -0.374322622927677 0.359833904291177 no 2167 0.354082151417135 3048 7175 A pharmaceutical preservative. SGTC_2273 7815444 169.05 µM -0.374431952463914 0.359793323436299 no 2168 0.354041487185389 3217 2824616 SGTC_411 enrofloxacin 100 µM -0.374750206985483 0.359675202961403 no 2169 0.353923124481771 3233 71188 A bacterial gyrase inhibitor. SGTC_805 3852-0218 479 µM -0.375598047102448 0.359360591722415 no 2170 0.353607871414338 3035 6615355 SGTC_521 r062-0005 13.8 µM -0.376842789786514 0.358898873098653 no 2171 0.353145219661296 3047 2832033 SGTC_1369 1866-0067 208 µM -0.377341111270758 0.358714085947718 no 2172 0.352960061995849 3210 3531355 SGTC_701 4424-0219 185 µM -0.379196395419007 0.358026402084899 no 2173 0.352271014046006 3238 2911779 SGTC_772 k072-0172 35.3 µM -0.379813295577349 0.35779784234886 no 2174 0.352042006104451 3072 5861980 SGTC_588 3970-1144 52.9 µM -0.380491212471988 0.357546734874927 no 2175 0.351790409183106 3160 1888707 SGTC_1770 st043884 66.3 µM -0.3817696687694 0.357073349203638 no 2176 0.351316109287092 3052 670149 SGTC_51 1013-0126 23.419 µM -0.381936629356585 0.357011543406709 no 2177 0.351254184946194 3344 1627850 SGTC_1904 st060225 78 µM -0.382376443299612 0.356848750185975 no 2178 0.351091080392071 3133 66595 SGTC_1926 methyl fluorone black 53.6 µM -0.385739701783861 0.355604733694771 no 2179 0.349844728180201 3099 72721 Reacts with homocysteine. SGTC_2083 5306046 65.942 µM -0.385930383337549 0.355534249486758 no 2180 0.349774113934549 3102 539837 SGTC_847 0342-0274 5.54 µM -0.386000346706548 0.35550838921679 no 2181 0.349748206016447 3193 18097 SGTC_2967 9089538 49.85 µM -0.386167333939538 0.355446669106931 no 2182 0.349686372320344 3281 728216 SGTC_1603 st002045 67.8 µM -0.386670732029154 0.355260631207833 no 2183 0.349499993194341 3211 5887985 SGTC_2451 5856223 45.7 µM -0.386988185670826 0.355143329445162 no 2184 0.349382477164871 3099 2179896 SGTC_3060 1327-0027 12.5 µM -0.387491530352785 0.354957367535132 no 2185 0.349196176975922 3139 16000455 YPR107C YTH1 SGTC_1336 1486-0901 104 µM -0.390196720201254 0.353958521372848 no 2186 0.348195543350054 3132 5006114 SGTC_2595 hexamethylquercetagetin 100 µM -0.391715752444781 0.35339808389631 no 2187 0.347634124789166 3136 386331 SGTC_197 4544-0043 41.561 µM -0.392217038671092 0.353213207131973 no 2188 0.347448927834561 3111 896523 SGTC_476 mead acid 10 µM -0.392550345228977 0.353090301243611 no 2189 0.347325810031835 3081 5312531 An omega 9 fatty acid. SGTC_309 k408-0051 1.48 µM -0.392738286232705 0.353021005264454 no 2190 0.347256394906377 3144 3640463 SGTC_1334 1486-0610 236 µM -0.393602200216137 0.3527025331144 no 2191 0.346937378277981 3183 3742339 SGTC_396 dithiazanine 1.25 µM -0.394319335242773 0.352438247748006 no 2192 0.346672644939367 3100 10578 An antihelmenthic. SGTC_1688 st021091 57.6 µM -0.39576353472533 0.351906233985153 no 2193 0.346139740040821 3216 3656366 SGTC_3043 9092303 49.47 µM -0.396786229147305 0.351529669333274 no 2194 0.345762553241891 3147 25236084 SGTC_2268 7933382 153.85 µM -0.397241401260378 0.35136211796623 no 2195 0.345594727348575 3153 935025 YOR257W CDC31 SGTC_1681 tripelennamine 100 µM -0.397911526846963 0.351115493605934 no 2196 0.345347701479031 3183 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_597 k018-0003 82.8 µM -0.398876394744682 0.350760506233966 no 2197 0.344992141568916 3228 6786234 SGTC_1392 3455-1037 33.9 µM -0.399818210731449 0.35041412556924 no 2198 0.34464520838287 3254 981132 SGTC_1977 st070720 65.3 µM -0.400614452437763 0.350121381145061 no 2199 0.34435200172438 3212 682188 SGTC_798 1287-0182 476 µM -0.40103824874623 0.349965605449725 no 2200 0.344195981832045 3278 1649755 SGTC_3162 9099653 49.47 µM -0.401673077229027 0.349732307458143 no 2201 0.343962320416554 3244 25237511 SGTC_1827 berberine 7.24 µM -0.402822176286356 0.349310160556552 no 2202 0.343539522921224 3106 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_147 4466-0538 29.23 µM -0.404551546432194 0.348675189647397 no 2203 0.342903590459705 3320 6742687 YHR072W ERG7 SGTC_2328 6201408 200 µM -0.405291709695741 0.348403554090887 no 2204 0.342631549817895 3217 2890418 SGTC_1719 st032227 49.2 µM -0.406922703323428 0.347805263555866 no 2205 0.342032380312769 3106 3125804 SGTC_2669 eugenol 100 µM -0.407325697131948 0.347657493331279 no 2206 0.341884395803335 3175 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2658 polymyxin b sulfate 77.05 µM -0.407956860458693 0.347426104163557 no 2207 0.341652673331417 3144 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_180 1486-1293 102.781 µM -0.408490663527379 0.34723045235417 no 2208 0.341456741828609 3292 4140536 SGTC_3132 9126706 49.47 µM -0.409575788208723 0.346832853290466 no 2209 0.341058580405378 3299 850858 SGTC_1247 0448-0043 5.84 µM -0.412568146141516 0.345737302175526 no 2210 0.339961521629551 3227 3089013 YGL099W LSG1 SGTC_791 1348-1292 225 µM -0.41679211869785 0.344193034841797 no 2211 0.338415233823764 3161 5437054 SGTC_3225 9130819 49.47 µM -0.417446265190988 0.343954112891474 no 2212 0.338176010251393 3255 4547121 SGTC_2706 st078239 82.5 µM -0.41939933962864 0.343241138512183 no 2213 0.337462153324639 3196 15434492 SGTC_2489 cantharidin 73.42 µM -0.419454702423771 0.343220936310004 no 2214 0.337441926498423 3185 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1090 efavirenz 20.7 µM -0.419624490865067 0.343158982326026 no 2215 0.337379897131787 3177 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3265 9137266 49.47 µM -0.419800861916238 0.343094630881975 no 2216 0.337315467598367 3204 17224265 SGTC_2225 6654152 15.4 µM -0.421329602534283 0.342537039320902 no 2217 0.336757208393522 3191 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_153 4077-0274 519.67 µM -0.421497860753124 0.342475689890398 no 2218 0.336695786489441 3413 3121976 SGTC_3088 9117578 49.47 µM -0.422552393263836 0.342091286466982 no 2219 0.336310933408044 3254 678341 SGTC_886 0866-0150 153 µM -0.424821241062213 0.341264789871411 no 2220 0.33548349602438 3295 271463 SGTC_2447 5741742 33.78 µM -0.42630685892996 0.340724020452778 no 2221 0.334942130309483 3243 1776504 SGTC_1644 st010134 20.9 µM -0.426671894381162 0.340591196469258 no 2222 0.334809162197028 3274 3818134 SGTC_1103 duloxetine 36.1 µM -0.427409610828672 0.340322826900369 no 2223 0.334540504228162 3299 60835 A selective serotonin reuptake inhibitor. SGTC_343 4130-2827 29.8 µM -0.427442408827826 0.340310897383532 no 2224 0.334528561978765 3183 1118244 SGTC_230 MPP+ 141.667 µM -0.427594792299503 0.340255473501499 no 2225 0.334473079039498 3213 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1044 1222-0021 1.78 µM -0.427632663447176 0.340241699800053 no 2226 0.334459290686314 3211 4306703 SGTC_2210 7115885 190.385 µM -0.428435638463936 0.339949708726431 no 2227 0.334166991342051 3182 2927039 SGTC_1479 0549-0158 134 µM -0.428659542257413 0.339868306227527 no 2228 0.334085503697131 3196 5440202 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.429658923716927 0.339505062025101 no 2229 0.333721883773475 3209 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3230 9131665 49.47 µM -0.430271981463047 0.339282308261382 no 2230 0.333498903023935 3188 15943720 SGTC_2979 9012552 45.46 µM -0.430556671288997 0.339178885658224 no 2231 0.33339537591759 3260 17100905 SGTC_1848 st056003 16.4 µM -0.43167999898436 0.338770919553078 no 2232 0.332987003057337 3268 146492 SGTC_2964 9083345 53.42 µM -0.431832056878434 0.338715710233338 no 2233 0.332931739363465 3198 17741579 SGTC_3036 9090181 49.47 µM -0.432399736088007 0.33850962736956 no 2234 0.332725454949027 3182 25236586 SGTC_2173 5763948 167 µM -0.433204548580605 0.3382175416053 no 2235 0.332433087347602 3221 2867177 SGTC_2404 5161160 200 µM -0.433344090328164 0.33816690845383 no 2236 0.332382405796016 3157 2831543 SGTC_111 0083-0039 52.457 µM -0.433786742354307 0.338006310179707 no 2237 0.332221654899146 3098 759313 SGTC_2254 7938975 95.19 µM -0.433980498673241 0.3379360228582 no 2238 0.332151301208105 3344 2969277 SGTC_2307 7538926 6.34 µM -0.434294863595296 0.337821995407129 no 2239 0.332037166638926 3185 96582 SGTC_2360 9040895 200 µM -0.436473990274835 0.337031985233537 no 2240 0.331246433154001 3202 4914414 SGTC_2107 5363541 170.161 µM -0.438141692944897 0.336427869228831 no 2241 0.330641786278616 3273 244052 SGTC_1511 0906-3109 28.5 µM -0.439486241818248 0.335941121073427 no 2242 0.330154624441339 3210 2882180 SGTC_1802 st050112 57.9 µM -0.439729563433674 0.335853064130034 no 2243 0.330066494000494 3208 4662563 SGTC_2826 7992541 19.48 µM -0.440346873520026 0.335629702962232 no 2244 0.329842948247192 3228 2985066 SGTC_2727 riluzole 51.77 µM -0.441051191462335 0.335374930681803 no 2245 0.329587968655767 3230 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_292 k038-0015 474 µM -0.442179935445211 0.334966789046342 no 2246 0.329179502097986 3281 46368540 SGTC_386 1509-0011 3.07 µM -0.443701478655072 0.334416923823144 no 2247 0.328629213137631 3196 3107280 SGTC_1447 4239-0816 81.9 µM -0.44417079769255 0.334247389835986 no 2248 0.328459551752296 3197 1341554 SGTC_3226 9131256 49.47 µM -0.444185079590604 0.334242231258889 no 2249 0.328454389322749 3225 17178073 SGTC_1434 4073-0095 163 µM -0.445113921748419 0.333906803631421 no 2250 0.328118714242966 3284 24133745 SGTC_2643 anethole 100 µM -0.445181786691335 0.333882301137553 no 2251 0.328094193908361 3245 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_214 4373-3496 70 µM -0.445455252482325 0.333783574070899 no 2252 0.327995395281376 3299 3779166 SGTC_186 3455-3465 67.277 µM -0.445675850164961 0.333703941919126 no 2253 0.327915705789044 3137 755278 SGTC_1442 4112-3290 3 µM -0.44629997987872 0.333478681895775 no 2254 0.327690285397673 3181 704353 SGTC_177 1327-0068 8.361 µM -0.446795945463128 0.333299721490885 no 2255 0.327511199519852 3285 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3004 9076122 71.4286 µM -0.44698960258507 0.333229854042964 no 2256 0.327441283551244 3313 44782551 SGTC_2712 st079126 47.7 µM -0.447208585551374 0.333150856530425 no 2257 0.327362231492048 3160 3152970 SGTC_1233 0325-0408 14.2 µM -0.447594459907478 0.333011671416603 no 2258 0.327222951085453 3291 12874 SGTC_2015 5119600 184 µM -0.450655216056908 0.331908470978634 no 2259 0.326119032071499 3328 2828786 SGTC_2172 5754775 163.918 µM -0.451370236482918 0.33165096274961 no 2260 0.3258613655181 3166 2263357 SGTC_1964 st076914 61 µM -0.451522961944126 0.331595970341509 no 2261 0.325806339760894 3252 24208661 SGTC_1274 0865-0114 173 µM -0.451749815700678 0.331514292990406 no 2262 0.325724613178337 3232 870624 SGTC_2493 resveratrol 26.09 µM -0.452702164138674 0.331171493026967 no 2263 0.325381610506112 3238 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2591 skatole 100 µM -0.453573277160156 0.330858057783293 no 2264 0.325067995457564 3293 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2552 juarezic acid 87.02 µM -0.454880526592268 0.330387918718526 no 2265 0.324597596627374 3193 1549512 SGTC_1098 clofazimine 15.1 µM -0.456624748895629 0.329761043546421 no 2266 0.323970393662097 3319 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3005 9076496 71.4286 µM -0.456888174473398 0.329666409637047 no 2267 0.323875712115203 3298 21368410 SGTC_1298 1079-1278 263 µM -0.45779915898546 0.329339228525515 no 2268 0.323548370041592 3278 2840950 SGTC_425 3825-7017 13.1 µM -0.458398594546062 0.329124011812342 no 2269 0.323333050611986 3382 3397440 SGTC_306 1672-3436 11.6 µM -0.460514422858768 0.328364814199881 no 2270 0.322573510731163 3306 6797378 SGTC_2688 kanamycin b 96.69 µM -0.462131287762513 0.327785130881389 no 2271 0.321993587171452 3404 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2961 9083290 32.55 µM -0.462394845076263 0.327690678789277 no 2272 0.321899097668633 3294 17741490 SGTC_720 r052-1644 49.9 µM -0.462927249598553 0.327499912477051 no 2273 0.321708257280245 3300 1422863 YOR257W CDC31 SGTC_1573 oleylamine 1.06 µM -0.463100059435014 0.327438002516803 no 2274 0.32164632370632 3248 5356789 An amine of the fatty acid oleic acid. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.463138905722645 0.327424086299465 no 2275 0.321632402209838 3316 5024745 SGTC_3307 9126885 69.2785 µM -0.464160952639446 0.327058036435564 no 2276 0.321266217279196 3196 24824909 SGTC_2122 5258151 111.688 µM -0.464206762552941 0.327041633338227 no 2277 0.321249808300615 3219 2173356 SGTC_1983 st071813 46.9 µM -0.465882290522739 0.326441908995853 no 2278 0.320649879027739 3260 11838595 SGTC_695 3505-6186 243 µM -0.465915813283576 0.326429914711735 no 2279 0.320637880845724 3307 1819379 SGTC_771 0250-0039 27.3 µM -0.46620577319996 0.326326175925762 no 2280 0.320534108675351 3219 3005115 SGTC_53 0973-0023 39.979 µM -0.468689850005964 0.325438000469358 no 2281 0.319645671531969 3383 674768 SGTC_465 cgp-37157 41 µM -0.469746272479312 0.32506057911307 no 2282 0.319268152082267 3259 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_795 0685-0265 78 µM -0.470213069605923 0.324893866601586 no 2283 0.319101398734857 3348 302754 SGTC_2278 7948257 134.34 µM -0.472842283387391 0.323955521582669 no 2284 0.318162852418741 3326 1247028 SGTC_3264 9137442 49.47 µM -0.473012974364047 0.323894641930315 no 2285 0.318101961383314 3429 17015726 SGTC_1011 4112-3381 17.4 µM -0.473863841782851 0.32359123682352 no 2286 0.31779850259836 3398 2877139 SGTC_826 1683-5028 118 µM -0.474306726690502 0.323433357841377 no 2287 0.317640597696281 3303 722377 SGTC_2612 dictamnine 15.46 µM -0.474454876120688 0.323380552836175 no 2288 0.317587784329282 3275 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_341 1486-1430 230 µM -0.475102087266611 0.323149908642692 no 2289 0.317357105420731 3187 2054753 YPL210C SRP72 SGTC_2922 7999257 32.47 µM -0.475977455985684 0.322838064941633 no 2290 0.317045219464618 3324 2988377 SGTC_87 0100-0052 35.5 µM -0.476103050634696 0.322793332977106 no 2291 0.317000481880577 3369 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2796 7949634 45.45 µM -0.476499433045188 0.322652173684828 no 2292 0.316859305582039 3233 2971588 SGTC_680 0417-1641 114 µM -0.477038103476561 0.322460383895038 no 2293 0.316667494456332 3184 2835990 SGTC_3335 9143315 29.6265 µM -0.477276407721319 0.322375552426194 no 2294 0.316582654201083 3240 4899691 SGTC_2099 5377090 177.372 µM -0.478852962842669 0.321814564005751 no 2295 0.316021617733507 3315 2243829 SGTC_3104 9120930 49.47 µM -0.480271669390126 0.321310090048448 no 2296 0.315517115509503 3342 17014836 SGTC_906 1165-0455 526 µM -0.481328812567574 0.320934397581498 no 2297 0.315141411198065 3281 3252859 SGTC_951 1171-0579 82.7 µM -0.486399177973591 0.319135020452034 no 2298 0.313342086636987 3316 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3000 9075062 71.4286 µM -0.48711217968433 0.318882329701976 no 2299 0.313089417790307 3245 17057871 SGTC_2811 7967822 32.47 µM -0.487202150116918 0.318850449787299 no 2300 0.313057540893657 3359 2232244 SGTC_590 k048-0076 22.4 µM -0.487624423158408 0.318700840447062 no 2301 0.312907946479295 3340 6832814 SGTC_2986 9022445 71.43 µM -0.488246342236939 0.318480551267439 no 2302 0.312687681566476 3374 6459286 SGTC_228 caffeine 993.056 µM -0.488425758537748 0.318417012364071 no 2303 0.312624150169444 3350 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_40 0327-0103 19.753 µM -0.488957257138412 0.318228817572127 no 2304 0.312435978942885 3230 409036 SGTC_2203 7227154 166.4 µM -0.489751179206561 0.317947790386638 no 2305 0.312154990658219 3343 896304 SGTC_3194 9111903 49.47 µM -0.489840821362304 0.317916066042351 no 2306 0.312123270984731 3410 17087251 SGTC_2434 5670830 169.91 µM -0.49259803577972 0.316940941904484 no 2307 0.31114831810342 3336 1549830 SGTC_1166 k206-0078 225 µM -0.492688616570458 0.316908928362706 no 2308 0.311116311094392 3318 5404595 SGTC_730 1436-0052 41.2 µM -0.493936795940414 0.316467929880988 no 2309 0.310675408503319 3353 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1400 3771-8998 51.5 µM -0.494421069644094 0.316296899690982 no 2310 0.310504418464728 3273 670767 SGTC_2019 4016004 108 µM -0.496019346258546 0.31573271779913 no 2311 0.30994038077725 3308 45595336 SGTC_690 glyoxal 20.3 µM -0.497813938214281 0.315099749166835 no 2312 0.30930759544096 3325 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2288 7946289 167.31 µM -0.497858233065131 0.315084132830227 no 2313 0.309291983914465 3425 1246052 SGTC_289 k017-0060 526 µM -0.498247573574363 0.314946883412675 no 2314 0.309154777369142 3282 5512909 SGTC_247 mechlorethamine 29.705 µM -0.50070586737887 0.314080881950822 no 2315 0.308289071166093 3294 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_110 0850-0284 111.64 µM -0.50115976599591 0.313921095418425 no 2316 0.308129343787278 3243 3906265 SGTC_193 1273-0060 1.558 µM -0.502325657307746 0.313510825096782 no 2317 0.307719232031312 3332 2847393 YHR072W ERG7 SGTC_1091 telmisartan 47.6 µM -0.502731423025914 0.313368092586171 no 2318 0.307576556942482 3397 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1452 4194-0072 190 µM -0.50589369208417 0.312256688971281 no 2319 0.306465640382203 3414 1343545 SGTC_90 0870-0863 4.608 µM -0.506138416033088 0.31217074987353 no 2320 0.306379741898441 3291 1738164 SGTC_187 1488-2104 32.728 µM -0.507936499134358 0.311539635162411 no 2321 0.305748938458918 3343 2852859 SGTC_1364 1653-0028 37.6 µM -0.508883258125806 0.311207551551879 no 2322 0.305417027843943 3344 5718652 SGTC_3243 9134147 49.47 µM -0.509271627649602 0.311071372117139 no 2323 0.305280921188712 3381 24282180 SGTC_1409 3909-8004 61.9 µM -0.509465499826348 0.311003401682157 no 2324 0.305212987479991 3331 2119279 SGTC_1105 epirubicin 18.1 µM -0.509717507885044 0.310915058788084 no 2325 0.30512469271843 3280 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2084 5306078 60.6385 µM -0.50997889506124 0.310823439502099 no 2326 0.305033123825952 3270 679340 SGTC_3178 9107506 49.47 µM -0.511066636495126 0.310442299306682 no 2327 0.304652198473865 3413 8897194 SGTC_719 2810-4230 27.3 µM -0.511222133812343 0.31038783028696 no 2328 0.304597760843266 3336 721079 SGTC_2603 homopterocarpin 100 µM -0.511998572464619 0.310115914505287 no 2329 0.304326004326743 3383 101795 A weak amylase inhibitor. SGTC_1524 corynanthine 62.1 µM -0.513962321392808 0.309428655519809 no 2330 0.303639166968147 3413 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_449 xestospongin c 11.1929 µM -0.51414182079157 0.309365868774059 no 2331 0.303576420106804 3374 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1632 st005650 90 µM -0.515892577144813 0.308753767200209 no 2332 0.302964719357784 3351 2759605 SGTC_2757 clomiphene 4.22 µM -0.516802281883347 0.308435924599718 no 2333 0.302647093484442 3495 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1917 st066507 28.5 µM -0.517012262423629 0.308362579678747 no 2334 0.30257379941024 3255 3156428 SGTC_1883 5-benzylidenerhodanine 20 µM -0.517251823780226 0.308278911700048 no 2335 0.302490189817409 3378 1273210 SGTC_603 3794-0023 45.9 µM -0.5176334437822 0.308145649612418 no 2336 0.302357021565988 3388 3802260 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.517658221393844 0.308136998119601 no 2337 0.302348376200877 3311 15053 SGTC_881 0833-0569 170 µM -0.518145329225285 0.307966938411253 no 2338 0.302178437828908 3311 5418700 SGTC_52 0329-0193 875 nM -0.518783093665882 0.307744343608145 no 2339 0.301956004394659 3482 3739292 SGTC_572 0960-0087 17.7 µM -0.519219104259198 0.307592206356997 no 2340 0.301803979098318 3331 6796365 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.519402592042098 0.307528191823628 no 2341 0.301740012075996 3593 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3298 9116858 71.43 µM -0.520267503946387 0.307226523538104 no 2342 0.301438570909092 3413 2506942 SGTC_1989 st071868 50.2 µM -0.520349296958219 0.307198002109707 no 2343 0.301410071229044 3399 16414057 SGTC_2244 6635614 200 µM -0.523199119486805 0.306204991046474 no 2344 0.300417847059621 3165 836499 SGTC_3129 9127257 49.47 µM -0.52350641893184 0.306097998402483 no 2345 0.300310942650056 3264 837894 SGTC_1419 3993-2473 62.6 µM -0.523666564543121 0.306042246957466 no 2346 0.300255237448336 3376 704026 SGTC_864 0469-0573 172 µM -0.52534261403652 0.305459034087503 no 2347 0.299672519275399 3327 689425 SGTC_1610 st001799 48.1 µM -0.526107338599552 0.305193097635635 no 2348 0.299406815039655 3269 621897 SGTC_2689 tacrolimus 100 µM -0.527492468925638 0.30471167407318 no 2349 0.298925822455615 3378 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_344 k064-0035 6.43 µM -0.528058735221659 0.304514956708106 no 2350 0.298729285129253 3284 5088750 SGTC_1312 1218-2183 165 µM -0.528423444848071 0.304388288793035 no 2351 0.298602734351715 3433 6744073 SGTC_580 1123-0028 41 µM -0.52918046838766 0.304125440574696 no 2352 0.298340132229397 3436 1677248 YPR107C YTH1 SGTC_637 1181-0519 7.26 µM -0.529209853188877 0.304115239836753 no 2353 0.298329941124378 3406 6252091 YGR060W ERG25 SGTC_299 1273-0059 1.44 µM -0.531224242280518 0.303416321912109 no 2354 0.29763169787666 3387 2848077 SGTC_1942 st076330 65.2 µM -0.531546091952243 0.303304718597051 no 2355 0.297520204973028 3470 24208414 SGTC_2969 9091408 28.7 µM -0.532518348358147 0.302967694313316 no 2356 0.297183518598158 3272 4286311 SGTC_555 4296-0685 37 µM -0.533111749535754 0.302762079319251 no 2357 0.296978113070161 3381 2908540 YHR072W ERG7 SGTC_1141 3253-0389 52.6 µM -0.535062194321581 0.302086686086375 no 2358 0.296303425565544 3408 5402031 SGTC_1122 capsaicin 818.572 nM -0.535984479840666 0.301767556016596 no 2359 0.29598463840605 3434 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_643 k048-0106 28.4 µM -0.536533144437971 0.301577778522835 no 2360 0.295795067709843 3423 6763920 SGTC_3258 9138477 49.47 µM -0.536881035741082 0.301457474286832 no 2361 0.295674895680202 3424 4970355 SGTC_1862 st057513 3.81 µM -0.537651351864453 0.30119116828282 no 2362 0.295408885401936 3307 5393163 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.540918807198165 0.300062756329525 no 2363 0.294281773581849 3338 6708630 An antioxidant. SGTC_1252 0493-0875 34.8 µM -0.542323744913081 0.299578151343077 no 2364 0.293797750374273 3355 3960963 SGTC_1617 st002906 78 µM -0.542519239755028 0.299510747450926 no 2365 0.293730428519322 3434 5150859 SGTC_3066 9117245 49.47 µM -0.543110667240035 0.29930687337987 no 2366 0.293526804245541 3376 17176980 SGTC_1965 Pectolinarigenin 58.4 µM -0.544739735457604 0.298745634506478 no 2367 0.29296626595156 3354 5320438 An anti-inflammatory. SGTC_1708 st033234 31.827 µM -0.545350198145889 0.298535444073665 no 2368 0.292756342778125 3490 674664 SGTC_302 1094-0063 18.9 µM -0.546912771222741 0.297997736075397 no 2369 0.292219330614231 3343 5440289 SGTC_998 3996-0085 177 µM -0.54726001720657 0.297878302793708 no 2370 0.292100054258493 3370 715391 SGTC_919 tnp00227 403.569 nM -0.547415305899195 0.297824899194611 no 2371 0.292046721106531 3374 1269246 A methoxyflavone. YNL221C POP1 SGTC_634 1611-4317 11.2 µM -0.548217335031172 0.297549151856863 no 2372 0.29177134026472 3476 2843522 SGTC_2080 5212524 12.4 µM -0.548573381450033 0.297426776148544 no 2373 0.291649128680307 3449 260183 SGTC_2134 5324836 1.464 µM -0.550743377398854 0.296681430462069 no 2374 0.290904802210222 3321 699272 SGTC_650 1328-0195 38 µM -0.551092976158033 0.29656143105461 no 2375 0.290784970045196 3436 2780821 SGTC_1979 st071809 45.3 µM -0.55247917433923 0.296085839017619 no 2376 0.290310049445231 3484 4976333 SGTC_1866 st057638 64 µM -0.554088891087306 0.295533999437136 no 2377 0.289759006199992 3386 688802 SGTC_526 4469-0568 170 µM -0.554499983144936 0.295393145603661 no 2378 0.289618358599546 3433 2901964 SGTC_2870 9038528 12.99 µM -0.554542907782663 0.295378439973793 no 2379 0.289603674570891 3447 6463316 SGTC_2583 asiatic acid 100 µM -0.555084423916546 0.295192949908934 no 2380 0.289418458106803 3493 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_793 0488-0545 106 µM -0.556798947658726 0.294606013693292 no 2381 0.288832401476968 3330 292548 SGTC_1684 st024538 14.6195 µM -0.556922281235731 0.294563813437679 no 2382 0.288790265274508 3385 6732859 SGTC_401 neomycin 50 µM -0.55730106785158 0.294434223902065 no 2383 0.288660873116 3409 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2352 9027995 87.8 µM -0.557497254740881 0.294367115278085 no 2384 0.288593867108809 3389 2997347 SGTC_502 l-744,832 89.3 µM -0.557794451364004 0.29426546823749 no 2385 0.288492376023412 3444 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1398 3558-0053 112 µM -0.558226561273038 0.294117707151611 no 2386 0.288344842773456 3346 4532369 SGTC_46 0329-0187a 2.197 µM -0.558419631489319 0.294051697383365 no 2387 0.288278935219439 3420 46494817 SGTC_1023 4482-3888 16 µM -0.558530660074578 0.294013740351551 no 2388 0.288241037083955 3479 3303168 SGTC_2486 5283202 22.39 µM -0.559639142143406 0.293634910946031 no 2389 0.287862800334401 3378 1377751 SGTC_3228 9131799 49.47 µM -0.563009501236958 0.292484463821623 no 2390 0.2867142070758 3405 17015818 SGTC_198 3454-2873 16.191 µM -0.563083060991115 0.292459378122047 no 2391 0.286689162707924 3397 710957 SGTC_2286 7945697 125 µM -0.564256919779193 0.292059198569945 no 2392 0.286289647748841 3408 1245733 SGTC_3007 9078383 71.4286 µM -0.564328776487087 0.292034710220523 no 2393 0.28626520038907 3382 6496995 SGTC_3115 9123671 49.47 µM -0.565419635376974 0.291663069293162 no 2394 0.285894186078036 3524 3286988 SGTC_1349 flufenamic acid 69 µM -0.566170576939217 0.291407361805123 no 2395 0.28563891469276 3426 3371 A non-steroidal anti-inflammatory. SGTC_3239 9133757 49.47 µM -0.566481428053777 0.291301542698286 no 2396 0.285533277241578 3450 17036923 SGTC_1014 4130-3005 69.3 µM -0.567417475167587 0.290983004399774 no 2397 0.285215289951981 3394 743608 SGTC_2810 7959871 45.46 µM -0.567716143291564 0.290881401429345 no 2398 0.285113864057673 3427 2974535 SGTC_135 0933-0004 26.348 µM -0.568437011021654 0.290636240036793 no 2399 0.284869132575001 3459 21230617 YGL099W LSG1 SGTC_1509 1326-1131 80 µM -0.569657290402873 0.290221453155509 no 2400 0.284455081553122 3451 768313 SGTC_1812 st052057 4.327 µM -0.570302960264968 0.290002094849888 no 2401 0.284236116726652 3432 3645418 SGTC_2426 5582046 32.21 µM -0.570379260864012 0.289976177806669 no 2402 0.284210246370454 3508 2251934 SGTC_1834 st055981 52.8 µM -0.570388177849803 0.28997314904279 no 2403 0.284207223065324 3518 471719 YDL150W RPC53 SGTC_3271 9137798 49.47 µM -0.572117689417511 0.28938597980918 no 2404 0.28362112287831 3441 6498326 SGTC_914 3820-6779 408 µM -0.573401477095685 0.288950495381128 no 2405 0.283186445211122 3418 2893481 SGTC_1467 k284-1082 293 µM -0.574818085406074 0.288470313908938 no 2406 0.282707167036105 3473 3334705 SGTC_646 4092-0839 27.3 µM -0.575055515680798 0.288389870029061 no 2407 0.282626875894133 3522 877796 SGTC_2299 7976368 114.88 µM -0.57545507826661 0.288254517891637 no 2408 0.282491781662466 3454 2979718 SGTC_2639 lactacystin 53 µM -0.576153781760817 0.288017903570221 no 2409 0.282255620952206 3512 3870 A proteasome inhibitor. SGTC_2892 9047358 58.44 µM -0.576855004983208 0.287780528164236 no 2410 0.282018704142434 3403 6466771 SGTC_376 3970-0862 59.1 µM -0.576909852710848 0.287761965218847 no 2411 0.282000177208612 3465 3135186 SGTC_1594 piperine 70.1 µM -0.579021709967487 0.287047648044834 no 2412 0.281287262224408 3466 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_813 k007-0158 173 µM -0.579944092870895 0.286735923824666 no 2413 0.280976159966837 3458 6523916 SGTC_7 0192-1582 4.227 µM -0.580295000869718 0.286617374751384 no 2414 0.280857849032387 3507 252616 SGTC_1309 pyrazolanthrone 13.4 µM -0.580422115438918 0.286574436711935 no 2415 0.280814997464358 3495 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_330 1488-0319 80.1 µM -0.581807212977228 0.286106762393608 no 2416 0.280348272506754 3466 6846614 SGTC_152 4469-0003 551.229 µM -0.581869305778446 0.286085805427219 no 2417 0.28032735840521 3501 697280 SGTC_1488 4013-0813 75.9 µM -0.582424450628401 0.285898470682833 no 2418 0.280140408062421 3427 2910057 SGTC_2125 5246583 200 µM -0.58263047232997 0.285828963086859 no 2419 0.280071043656386 3556 835267 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.582968710395283 0.285714865767327 no 2420 0.279957182046271 3495 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3287 9117173 37.0625 µM -0.58303591070022 0.285692199773413 no 2421 0.27993456297516 3432 2789709 SGTC_1519 esterone 74 µM -0.583593904873956 0.285504026943387 no 2422 0.279746780952087 3410 698 A steroid. SGTC_2621 lithochol-11-enic acid 100 µM -0.585421866634696 0.28488799551002 no 2423 0.279132044603721 3516 6708711 SGTC_851 0394-0702 453 µM -0.585555750373242 0.284842901013924 no 2424 0.279087045854495 3513 762646 SGTC_2 0422-0095 29 µM -0.585697006267544 0.284795327133067 no 2425 0.279039573124658 3415 6790840 SGTC_420 mitomycin C 81.9 mM -0.587348689601336 0.284239334656244 no 2426 0.278484773442362 3470 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_412 gemfibrozil 100 µM -0.58928451660673 0.283588354503606 no 2427 0.277835214839901 3489 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_435 c-PAF 6.7 µM -0.590695260058084 0.283114399921117 no 2428 0.277362312218232 3453 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1949 st076024 69.1 µM -0.590823188756906 0.283071439689744 no 2429 0.277319448047153 3441 2921930 SGTC_43 0570-0105 72.5 µM -0.591387348073412 0.282882024496678 no 2430 0.277130457797106 3520 1114046 YDL195W SEC31 SGTC_2783 7738165 71.43 µM -0.592739103627006 0.282428423484564 no 2431 0.276677883735254 3432 17201110 SGTC_2429 5902844 64.44 µM -0.593869675586528 0.282049312654259 no 2432 0.276299641310477 3482 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3063 1327-0034 4 µM -0.594412476585489 0.281867384164193 no 2433 0.276118132822549 3461 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1789 tunicamycin 25 nM -0.59452897824617 0.281828344129428 no 2434 0.276079183192615 3527 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2234 tolnaftate 200 µM -0.594560483594053 0.28181778704622 no 2435 0.276068650573188 3460 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1260 0700-1617 7.75 µM -0.595549734229757 0.281486397405969 no 2436 0.275738032493294 3498 2853078 SGTC_854 0422-0053 192 µM -0.596125594590427 0.281293576224115 no 2437 0.275545663494056 3523 3596728 SGTC_2589 lobaric acid 100 µM -0.596475091798921 0.281176581620731 no 2438 0.27542894441799 3445 73157 A novel microtubule depolymerizer. SGTC_2742 clothiapine 36.27 µM -0.597138217331292 0.280954664181075 no 2439 0.275207552021743 3472 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM -0.59727764836963 0.280908013835146 no 2440 0.27516101245079 3513 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1183 1254-0324 198 µM -0.599877259640076 0.280038931403769 no 2441 0.274294019363731 3537 5799357 SGTC_1137 ixabepilone 100 µM -0.601185778110155 0.279601971066253 no 2442 0.273858127930526 3539 154225 A novel microtubule stabilizer. SGTC_2252 omeprazole 400 µM -0.601419643765913 0.279523909975554 no 2443 0.273780259094638 3466 4594 A proton pump inhibitor. SGTC_3160 9100216 49.47 µM -0.602462167616988 0.279176058854633 no 2444 0.273433269482573 3482 17191039 SGTC_424 splitomicin 100 mM -0.603718172645805 0.278757256739334 no 2445 0.273015514999383 3492 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_44 0929-0055 61.211 µM -0.60373444789417 0.278751831930783 no 2446 0.273010103835601 3433 1379590 SGTC_2873 9040596 71.43 µM -0.603859814418042 0.278710046924481 no 2447 0.272968423993196 3532 6463863 SGTC_3158 9100007 49.47 µM -0.603993814874685 0.278665387576551 no 2448 0.272923877168544 3472 19297233 SGTC_1311 1190-0148 100 µM -0.6061644546437 0.277942447773473 no 2449 0.272202776904418 3564 1961333 SGTC_2477 5967686 25.23 µM -0.606486345413613 0.27783531881642 no 2450 0.272095923431623 3502 776118 SGTC_389 tpck 16.7 µM -0.606616624335066 0.277791966221551 no 2451 0.272052682531211 3503 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3293 9120939 62.045 µM -0.607588041791193 0.277468814210664 no 2452 0.271730366953572 3533 934087 SGTC_15 0266-0086 27.098 µM -0.608843285513142 0.277051516778479 no 2453 0.271314159712386 3588 1712902 YIL048W NEO1 SGTC_453 enantio-paf c16 10 µM -0.609750748113754 0.276750028292849 no 2454 0.271013465942308 3543 13871343 A lipid and platelet activating factor SGTC_1951 sophoraflavanone G 9.2 µM -0.610817121894817 0.276395949904879 no 2455 0.270660328485017 3504 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_796 1234-0020 70.7 µM -0.611208630853392 0.27626600918806 no 2456 0.270530735132136 3507 46495034 SGTC_880 0833-0487 87.2 µM -0.613073979530034 0.275647317176077 no 2457 0.269913712218759 3522 76075 SGTC_2973 9094665 17.96 µM -0.614309677958975 0.275237840687309 no 2458 0.269505354229022 3576 25237061 YIL048W NEO1 SGTC_168 3970-0862 530.542 µM -0.614382748706224 0.275213636430742 no 2459 0.26948121643222 3550 3135186 SGTC_958 1222-0007 33 µM -0.61487236357895 0.275051481415172 no 2460 0.269319507653992 3606 7312461 SGTC_2417 cerulenin 830 nM -0.615225418936337 0.274934582606408 no 2461 0.269202931614607 3604 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.615619956670118 0.274803977698419 no 2462 0.269072688384156 3530 5106787 A p450 inhibitor. SGTC_1037 k284-1091 78.7 µM -0.616100495909492 0.274644944798548 no 2463 0.268914097403296 3547 3334711 SGTC_611 3453-1652 23.7 µM -0.61689015865525 0.274383707102243 no 2464 0.268653589250711 3547 1560575 SGTC_3022 9087993 49.47 µM -0.618881869226382 0.273725351032901 no 2465 0.267997091719325 3564 17173644 SGTC_143 4032-1194 15.74 µM -0.620782549026867 0.273097814478618 no 2466 0.267371353388861 3553 1806963 SGTC_3315 9136395 68.55 µM -0.620803660790118 0.273090848134742 no 2467 0.267364407153679 3613 16876844 SGTC_639 0833-0042 114 µM -0.621070251704267 0.273002887505441 no 2468 0.267276700703942 3521 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_754 3474-0146 171 µM -0.62310573609664 0.272331750783046 no 2469 0.266607520273753 3472 24762078 SGTC_1346 1488-2224 62.4 µM -0.623259125864153 0.272281208580689 no 2470 0.26655712660853 3563 3722427 SGTC_2176 5809774 33.9695 µM -0.624367370917654 0.271916178402379 no 2471 0.266193174255291 3534 2870539 SGTC_1665 st014639 11.4 µM -0.626127408308854 0.271336963717735 no 2472 0.26561568804035 3616 981133 YIL048W NEO1 SGTC_2147 5545932 89.7195 µM -0.626299211968729 0.271280457418816 no 2473 0.265559351563679 3552 797404 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.626625245480897 0.271173240983282 no 2474 0.265452457939196 3579 676296 Flavone; oxidizing agent. SGTC_3071 9117417 49.47 µM -0.62833855293224 0.270610165643363 no 2475 0.264891090541416 3480 45595590 YGL055W OLE1 SGTC_1633 st005664 67.9 µM -0.629236362241985 0.270315335632604 no 2476 0.264597163285201 3555 2063822 SGTC_1849 st056239 19.2 µM -0.632200897954048 0.269342958965138 no 2477 0.263627805320053 3471 5393181 SGTC_799 1310-0557 151 µM -0.632726327308773 0.26917079970686 no 2478 0.263456187145094 3599 5354492 SGTC_182 3448-4371 550.524 µM -0.634955105010545 0.268441145111295 no 2479 0.26272884796623 3597 3491403 SGTC_2077 5212015 200 µM -0.63509855402732 0.26839421702987 no 2480 0.262682070031227 3503 780900 SGTC_2891 9063876 19.48 µM -0.636584942429877 0.267908201145263 no 2481 0.262197617906236 3522 6472478 SGTC_2249 haloperidol 116.36 µM -0.638834772627375 0.267173400978607 no 2482 0.261465212323688 3593 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_890 0929-0006 47.2 µM -0.641196187168665 0.266403252826761 no 2483 0.260697613276586 3543 1378169 SGTC_2711 st079103 59.1 µM -0.642841379940182 0.265867356808769 no 2484 0.260163514827287 3577 54693780 SGTC_1339 1486-1321 22.7 µM -0.647032310880876 0.264504698861024 no 2485 0.258805516003654 3588 3469382 SGTC_3102 9121669 49.47 µM -0.649302535161343 0.263768034833956 no 2486 0.258071423721514 3599 41905072 SGTC_482 fipronil 114 µM -0.64968933959186 0.263642625244253 no 2487 0.257946455660264 3618 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2752 diclazuril 33.15 µM -0.651142041586566 0.26317190254424 no 2488 0.257477399888948 3643 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2087 5276107 200 µM -0.651537388461718 0.263043871662839 no 2489 0.257349825033313 3586 144405 SGTC_2875 9039966 71.43 µM -0.654182704369809 0.26218802070993 no 2490 0.256497051555751 3610 6463691 SGTC_2519 cryptotanshinone 88.04 µM -0.654370882315349 0.26212719305531 no 2491 0.256436444553276 3594 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1499 4480-0877 67.3 µM -0.655138126744534 0.261879259701159 no 2492 0.256189413227176 3547 2861909 SGTC_1629 st005085 44.9 µM -0.656170216176381 0.261545932069726 no 2493 0.255857305018265 3596 24207091 SGTC_2641 levomentholum 100 µM -0.657125968506087 0.261237452911092 no 2494 0.255549961247158 3574 16666 SGTC_1988 st071872 53.4 µM -0.657364837177053 0.261160384734635 no 2495 0.255473177759491 3626 16414116 SGTC_1152 3909-8331 15.9 µM -0.657404056913296 0.261147732063348 no 2496 0.255460571866443 3590 16001939 SGTC_166 k072-0058 166.424 µM -0.657530144211472 0.261107057199855 no 2497 0.255420047457522 3627 5846229 SGTC_1397 3532-0190 20.1 µM -0.659449389962286 0.26048832448383 no 2498 0.254803617598713 3535 5322280 SGTC_1129 3453-1384 223 µM -0.660533540381033 0.260139146531912 no 2499 0.2544557510216 3666 1084452 SGTC_1738 st035555 74 µM -0.660964794814174 0.260000317284496 no 2500 0.254317445525371 3618 5331140 SGTC_93 0109-0045 59.227 µM -0.661266460230072 0.259903227994855 no 2501 0.25422072331716 3670 88733 SGTC_71 0417-1750 47.813 µM -0.661363862067044 0.259871883764891 no 2502 0.25418949773606 3600 6811472 SGTC_821 1114-0266 29.2 µM -0.662208843712282 0.259600047767764 no 2503 0.253918693612798 3608 3123235 SGTC_2408 sulbentine 18.36 µM -0.664528482971502 0.258854560386141 no 2504 0.253176062594774 3571 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1278 0874-0585 172 µM -0.66464640050963 0.258816693567344 no 2505 0.253138341903527 3614 766306 SGTC_1139 k015-0024 46.9 µM -0.66564707320235 0.258495463303068 no 2506 0.252818355310443 3611 2766652 SGTC_2982 9019404 25.97 µM -0.666081220993619 0.258356159904679 no 2507 0.252679593490158 3516 22333232 SGTC_1149 3909-7961 23.3 µM -0.6675826683887 0.257874696082374 no 2508 0.25220001199174 3590 735261 SGTC_1319 1306-0155 43.7 µM -0.667742809416674 0.257823371715736 no 2509 0.252148889244399 3653 3122360 SGTC_1561 5-methoxyflavone 52.9 µM -0.667889002945444 0.257776522079241 no 2510 0.25210222381095 3592 94525 SGTC_544 k015-0020 52.4 µM -0.66818103720344 0.257682949096427 no 2511 0.252009019200567 3620 3008304 SGTC_989 1501-0895 10.3 µM -0.668543609771426 0.257566798924858 no 2512 0.251893327140364 3616 2830112 SGTC_2622 2-methoxyxanthone 59.94 µM -0.668850387819577 0.25746854377554 no 2513 0.251795460264813 3638 71034 A hepatoprotective. SGTC_1030 k029-0042 36.7 µM -0.669094835161438 0.257390265902493 no 2514 0.25171749220892 3622 6080581 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.671586097609659 0.256593209992965 no 2515 0.250923615617889 3633 7104 SGTC_1767 st044992 70.3 µM -0.673366311388405 0.256024435896986 no 2516 0.250357137751926 3604 9600693 SGTC_2094 5332512 191.667 µM -0.673684131088872 0.255922962488089 no 2517 0.250256076418418 3667 755774 SGTC_865 0488-0499 301 µM -0.675267590645519 0.255417708770976 no 2518 0.249752885382248 3655 9634651 SGTC_2269 7935389 174.42 µM -0.676227603193854 0.255111639888912 no 2519 0.249448074845037 3610 97605 SGTC_1256 0570-0116 285 µM -0.67642697858067 0.255048099574547 no 2520 0.249384796600785 3631 410638 SGTC_2841 9004761 38.96 µM -0.676908447904971 0.254894690944703 no 2521 0.249232021885818 3553 2991039 SGTC_2777 climbazole 1.536 µM -0.67709850703202 0.254834146468057 no 2522 0.24917172805258 3615 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_118 0083-0097 135.343 µM -0.680807906529465 0.253654003806151 no 2523 0.247996523250257 3721 5207356 SGTC_3233 9132340 49.47 µM -0.684165738856212 0.252588192399697 no 2524 0.246935257065497 3624 17682950 SGTC_1669 st015249 58.4 µM -0.684252146018259 0.252560797024106 no 2525 0.246907979595282 3716 722793 SGTC_2141 5621638 7.665 µM -0.684510421836607 0.252478920054369 no 2526 0.246826455333081 3658 2856238 SGTC_1732 st034308 51.822 µM -0.68617448207513 0.251951725738269 no 2527 0.246301543616717 3579 830119 SGTC_38 0929-0051 58.268 µM -0.686411773314497 0.251876596372528 no 2528 0.246226741170956 3659 1379719 SGTC_2383 9036125 200 µM -0.686511398685016 0.251845057262732 no 2529 0.2461953394227 3607 79580 SGTC_2369 9071472 200 µM -0.688289378867323 0.251282540261662 no 2530 0.245635284407673 3687 17296037 SGTC_1340 1486-1359 257 µM -0.688898114914114 0.251090101247907 no 2531 0.245443692900717 3619 4309068 SGTC_620 0109-0052 432 µM -0.689280562780527 0.250969238341533 no 2532 0.245323363648721 3659 493037 SGTC_3025 9087895 49.47 µM -0.6894888725776 0.250903420290056 no 2533 0.245257836653272 3667 17173641 SGTC_631 k072-0230 41.5 µM -0.692666785524306 0.249900453374267 no 2534 0.244259343876943 3678 5773147 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.692966476826476 0.249805979067129 no 2535 0.244165294778032 3674 6708739 YPR165W RHO1 SGTC_231 b-estradiol 524 µM -0.693077293251227 0.249771050240279 no 2536 0.2441305233227 3609 450 A steroid. SGTC_1875 nocodazole 6 µM -0.693336744733011 0.249689282471955 no 2537 0.244049124305698 3650 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2129 girgensonine 121.053 µM -0.695268542438353 0.24908091152251 no 2538 0.243443512250746 3712 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2463 5473429 200 µM -0.695485194082761 0.249012731765355 no 2539 0.243375643363877 3654 5399405 SGTC_885 0865-0106 16.8 µM -0.696404605077026 0.248723505834919 no 2540 0.243087739954898 3640 2793380 SGTC_518 1021-0119 62.6 µM -0.6968645684535 0.248578878909167 no 2541 0.242943776647341 3644 1097762 SGTC_73 0327-0325 16.231 µM -0.699863984061936 0.247636868128838 no 2542 0.242006125756548 3697 53298 SGTC_2848 9016370 25.97 µM -0.700095684064198 0.247564178738056 no 2543 0.241933775498278 3679 7894410 SGTC_1748 st037455 53.6035 µM -0.700672003308525 0.247383424153968 no 2544 0.241753865908394 3673 580690 SGTC_3290 9121031 71.43 µM -0.700896304885489 0.247313094131349 no 2545 0.241683865314759 3671 17014854 SGTC_2805 7950783 58.44 µM -0.701477743376294 0.247130833188509 no 2546 0.241502459783764 3690 1178958 YDL195W SEC31 SGTC_1980 st071811 45.7 µM -0.70168402259979 0.24706618902543 no 2547 0.241438119604818 3718 4974850 SGTC_1222 0366-0074 1.18 µM -0.702779255647903 0.246723114447001 no 2548 0.241096663459519 3712 286520 SGTC_1774 st048371 48.465 µM -0.702879183761126 0.246691825323899 no 2549 0.241065522372594 3667 4242727 SGTC_2450 5739737 12.93 µM -0.703910909199147 0.246368899515412 no 2550 0.240744128621323 3687 2262825 SGTC_1220 1838-0075 193 µM -0.703934508002627 0.246361515838599 no 2551 0.240736780064909 3639 5529645 SGTC_496 calpeptin 138 µM -0.703940438704138 0.246359660238457 no 2552 0.240734933291545 3641 73364 A calpain inhibitor. SGTC_2090 5301565 104.445 µM -0.704492889451475 0.24618684209381 no 2553 0.24056293832885 3708 2056344 SGTC_371 0195-0006 7.36 µM -0.704787030288936 0.246094855217713 no 2554 0.240471390512387 3584 3928593 SGTC_3165 9101544 49.47 µM -0.705326982355601 0.245926043613775 no 2555 0.24030338628539 3672 5002184 SGTC_2226 7298446 200 µM -0.706164845324629 0.245664215675665 no 2556 0.240042814765944 3678 3283010 SGTC_2292 7671323 168.05 µM -0.706691112443591 0.245499836438216 no 2557 0.239879226919871 3684 937504 SGTC_1700 st030840 7.9285 µM -0.708275448794991 0.245005326815816 no 2558 0.239387110156989 3714 5499307 SGTC_598 3937-0236 20.2 µM -0.709378273814964 0.244661425092725 no 2559 0.239044883229224 3745 1379313 SGTC_765 1319-0117 244 µM -0.710777169907674 0.244225571685345 no 2560 0.238611165061433 3666 3487746 YGL099W LSG1 SGTC_3017 9080681 49.47 µM -0.710777898235889 0.244225344869541 no 2561 0.23861093936048 3697 16451914 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.710985870994853 0.244160582687641 no 2562 0.238546495656023 3707 688664 SGTC_1313 1220-0047 237 µM -0.711102011371874 0.244124420903078 no 2563 0.238510511838305 3707 3528706 SGTC_2762 leflunomide 42.06 µM -0.713219343965212 0.243465669035331 no 2564 0.237855019035072 3687 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3050 9093513 49.47 µM -0.713378422686452 0.24341621472636 no 2565 0.23780581070106 3702 25236664 SGTC_1359 1582-0056 520 nM -0.716168467142757 0.242549730221006 no 2566 0.236943665607731 3756 3661189 SGTC_1491 4138-0063 26.5 µM -0.71784628555062 0.242029467348524 no 2567 0.236426035306784 3662 23883227 SGTC_809 3998-0021 90 µM -0.720081412662504 0.241337333746653 no 2568 0.235737435523054 3637 715485 SGTC_2827 7993847 71.43 µM -0.721345867081712 0.240946257245078 no 2569 0.235348371708292 3713 2985692 SGTC_2372 9071633 200 µM -0.72291514165499 0.240461384239262 no 2570 0.234866010165647 3751 21321366 SGTC_1033 k072-0102 21.3 µM -0.723023056039366 0.240428060491641 no 2571 0.234832859676135 3678 5965931 SGTC_2813 7971799 71.43 µM -0.723302961111672 0.240341638085283 no 2572 0.234746886992387 3760 2234054 SGTC_2983 9022671 12.99 µM -0.72365045886009 0.240234369577338 no 2573 0.234640177472535 3701 6405161 SGTC_2004 4023728 41.89 µM -0.725536979483362 0.239652478167799 no 2574 0.234061333572335 3702 360084 YDR527W RBA50 SGTC_1810 st050138 53 µM -0.726622340111074 0.239318050976873 no 2575 0.233728669498369 3692 3444541 SGTC_884 0851-0618 334 µM -0.726787840815188 0.239267078414062 no 2576 0.233677966412639 3747 9642473 SGTC_531 3788-1495 174 µM -0.726825280352393 0.239255548233517 no 2577 0.233666497216223 3690 2896655 SGTC_2167 5876490 200 µM -0.727818814869365 0.238949682310955 no 2578 0.233362252741573 3844 686534 SGTC_1924 st058459 75.1 µM -0.727965731730946 0.238904471173335 no 2579 0.233317281880653 3676 688683 SGTC_2242 6630449 61.2675 µM -0.72832485438559 0.2387939770482 no 2580 0.233207375637553 3769 691249 YDR170C SEC7 SGTC_1567 st069303 68.4 µM -0.728425417372818 0.238763041044457 no 2581 0.233176604395105 3777 5581319 SGTC_2824 7998404 51.95 µM -0.728534587622545 0.238729459686864 no 2582 0.233143201970265 3698 837851 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.729212945945802 0.238520850935362 no 2583 0.232935706684011 3666 756377 SGTC_563 tetrahydrosecaminediol 614 µM -0.730133677466936 0.238237867288799 no 2584 0.232654238796388 3765 334274 A psychoactive constituent of the cannabis plant. SGTC_2474 5321570 43.32 µM -0.731193560435132 0.237912343777599 no 2585 0.232330466475134 3763 2841384 SGTC_148 3253-0744 288.01 µM -0.731615588526411 0.237782793550483 no 2586 0.232201615434113 3687 6893655 SGTC_3303 9125618 40.5795 µM -0.731997232547135 0.237665673370495 no 2587 0.23208512846147 3756 22695467 SGTC_1213 1315-0166 115 µM -0.732059172451645 0.237646668033346 no 2588 0.232066225975335 3759 768401 SGTC_1268 0828-0275 2.46 µM -0.732379418828084 0.237548418505171 no 2589 0.231968508584825 3787 745337 SGTC_3176 9106582 49.47 µM -0.732533071645381 0.237501286724362 no 2590 0.231921632341184 3612 17018027 SGTC_2349 9023730 187.07 µM -0.732550488679542 0.237495944511437 no 2591 0.2319163191032 3707 4126287 SGTC_1293 1000-1278 195 µM -0.732609222405338 0.237477929986284 no 2592 0.231898402300851 3772 678847 SGTC_221 trifluoperazine 10.304 µM -0.734008565268296 0.237048952187789 no 2593 0.231471758922829 3729 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2782 7736369 71.43 µM -0.734986561844516 0.236749393872781 no 2594 0.231173839134903 3785 2950836 YOL077C BRX1 SGTC_480 am 92016 50 µM -0.736000850369102 0.236438939463578 no 2595 0.230865090138955 3659 2129 K+ channel blocker. SGTC_1773 st048542 73.5835 µM -0.736229071518858 0.236369116209084 no 2596 0.230795651465836 3696 3237138 SGTC_1656 st012921 11 µM -0.736511895246276 0.236282603289418 no 2597 0.230709615574257 3680 6732821 SGTC_2419 paclitaxel 166.5 µM -0.737001906785411 0.236132754995169 no 2598 0.23056059490194 3682 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2795 7780010 54.55 µM -0.737487936697253 0.235984176033567 no 2599 0.230412838262245 3738 953673 SGTC_662 k832-1615 104 µM -0.737546270183611 0.235966346996113 no 2600 0.230395108015508 3776 5878478 SGTC_478 N-arachidonylglycine 10 µM -0.737895451357496 0.23585963884102 no 2601 0.230288991643542 3671 5283389 SGTC_2736 butenafine 14.65 µM -0.737963584917445 0.235838820641669 no 2602 0.230268289000494 3706 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2200 6600604 21.907 µM -0.738685787219906 0.23561821412194 no 2603 0.230048909066998 3702 2904777 SGTC_820 1582-0060 59.9 µM -0.739092901497632 0.235493905713081 no 2604 0.22992529347836 3747 3848840 SGTC_741 4582-0002 126 µM -0.739226949823622 0.235452983273412 no 2605 0.229884599377283 3699 2912688 SGTC_2705 st078069 42.8 µM -0.739560788757454 0.235351085566915 no 2606 0.22978327080168 3749 1530061 SGTC_2858 9025781 8.96 µM -0.740037160962716 0.235205724568641 no 2607 0.229638723081945 3737 4894980 YPL153C RAD53 SGTC_1843 st055809 45.5 µM -0.740576352948076 0.235041254470855 no 2608 0.229475175149911 3741 16413835 SGTC_1273 0849-0096 14.1 µM -0.740989273787759 0.234915343916965 no 2609 0.229349971979838 3763 5286025 SGTC_1579 chlormadinone acetate 49.4 µM -0.741673794985391 0.234706697322374 no 2610 0.229142500299851 3747 45114258 A steroidal progestin. SGTC_926 2268-1401 59.4 µM -0.741685356236168 0.234703174256686 no 2611 0.229138997101988 3732 2931578 SGTC_1038 k292-0204 154 µM -0.744359057317703 0.233889201765946 no 2612 0.22832964075543 3700 4454212 SGTC_979 1426-2828 121 µM -0.744903243614973 0.233723723320666 no 2613 0.228165107068563 3851 747872 SGTC_1270 0831-1170 17.3 µM -0.745047699227463 0.233679807556714 no 2614 0.228121442389308 3729 6764716 SGTC_317 4495-0002 170 µM -0.749162875313532 0.232430681375238 no 2615 0.226879521078855 3781 15991618 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.749484098856723 0.232333333243497 no 2616 0.226782739575232 3749 1273210 SGTC_2920 7982904 15.77 µM -0.749663713238224 0.232278910246432 no 2617 0.226728633678667 3760 6456808 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.750223481786941 0.232109346383795 no 2618 0.226560059285676 3748 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1253 0550-0034 176 µM -0.750655220668664 0.231978612066464 no 2619 0.226430089394342 3749 5969915 SGTC_1169 aniline yellow 25.8 µM -0.751184689493698 0.231818340255227 no 2620 0.226270756552474 3699 6051 A DNA damaging agent. SGTC_1131 3454-3128 32.3 µM -0.753433980053468 0.23113816129049 no 2621 0.225594584981933 3840 710982 SGTC_1004 4084-0029 199 µM -0.754495590976617 0.230817520471272 no 2622 0.225275845923333 3780 716894 YLR208W SEC13 SGTC_2725 haloperidol 53.21 µM -0.754628213617813 0.230777481608466 no 2623 0.225236045106101 3725 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_728 3030-5151 22.5 µM -0.754933740521027 0.230685257598891 no 2624 0.225144369883595 3788 3125388 SGTC_1324 1418-0026 34.4 µM -0.755552161051823 0.230498648947919 no 2625 0.224958873720227 3819 1372513 SGTC_3058 9093861 49.47 µM -0.756716455694869 0.230147551620663 no 2626 0.224609876965815 3767 17217477 SGTC_2465 5809242 33.21 µM -0.756998209081362 0.23006263283444 no 2627 0.224525467704489 3760 2731748 SGTC_2769 toremifene 3.73 µM -0.757962181247167 0.229772230032474 no 2628 0.224236811681369 3774 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2963 9082507 9 µM -0.75832694549775 0.229662396015757 no 2629 0.224127640062283 3798 16459611 SGTC_591 4299-0174 154 µM -0.758410889874698 0.229637123721405 no 2630 0.224102520318061 3755 5509088 SGTC_1769 st044406 64.4 µM -0.75867736862783 0.229556907949902 no 2631 0.224022789085756 3769 670903 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.759405824573308 0.229337707355358 no 2632 0.223804915168202 3758 688667 SGTC_1379 2144-0755 36.5 µM -0.760188044918418 0.229102459150858 no 2633 0.223571095016568 3825 5392327 SGTC_3316 9136639 10.545 µM -0.76055463330549 0.22899225643142 no 2634 0.223461562787506 3804 4903665 SGTC_2776 terbinafine 19.92 µM -0.760580195566808 0.228984573089275 no 2635 0.22345392622806 3790 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_173 1273-0061 2.693 µM -0.760847595871645 0.228904208275347 no 2636 0.223374051025022 3764 2847414 YPL266W DIM1 SGTC_115 0527-0192 112.043 µM -0.761053880208456 0.228842222146057 no 2637 0.223312442888633 3815 4233931 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.761662125055199 0.228659506249287 no 2638 0.223130842979538 3830 6708561 SGTC_3252 9135871 49.47 µM -0.761842221250386 0.228605421329034 no 2639 0.223077088908444 3783 17682838 SGTC_321 4534-3890 65.3 µM -0.764647512339322 0.22776388890619 no 2640 0.222240734418569 3794 699746 SGTC_2277 7947813 106.88 µM -0.765157071359244 0.227611218500206 no 2641 0.222089009461446 3866 1246798 SGTC_2336 9001819 198.65 µM -0.765925667181377 0.227381046388625 no 2642 0.2218602662779 3801 2989602 SGTC_524 r073-0010 27.8 µM -0.76720370028532 0.226998603078482 no 2643 0.221480206606996 3731 2772106 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.767278460424651 0.226976242815798 no 2644 0.221457986071685 3815 6708784 An antioxidant flavonoid SGTC_1262 0737-0114 49.6 µM -0.767398255305102 0.226940415550178 no 2645 0.221422382771355 3810 765919 SGTC_3205 9113483 49.47 µM -0.768472684769383 0.22661922666097 no 2646 0.221103206325152 3846 17018033 SGTC_2046 4110841 106 µM -0.768836338321184 0.226510574571395 no 2647 0.220995236885692 3797 44119630 YMR134W ERG29 SGTC_2566 crystal violet carbinol 226 nM -0.769432995898725 0.226332369475074 no 2648 0.220818153492509 3786 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_554 4483-2211 187 µM -0.770957713240973 0.225877338569108 no 2649 0.220365998372053 3817 747107 SGTC_558 k064-0027 21.3 µM -0.771397914091092 0.225746062985926 no 2650 0.220235555554159 3826 5088526 SGTC_10 0279-0212 42.575 µM -0.771469849207628 0.225724614780888 no 2651 0.22021424354118 3791 39851 YBR002C RER2 SGTC_3094 9117742 49.47 µM -0.772656075421254 0.225371095351823 no 2652 0.219862974252965 3731 17149698 SGTC_1462 k081-0014 26.5 µM -0.772889260121351 0.22530163847749 no 2653 0.219793960658137 3522 3270634 SGTC_1229 0139-0193 12.2 µM -0.772894779997314 0.225299994462769 no 2654 0.219792327140386 3800 3090752 SGTC_2054 5233173 129 µM -0.77382346337145 0.225023496372812 no 2655 0.219517597594804 3813 6889 SGTC_939 1165-0479 45.3 µM -0.775354039903335 0.224568215762049 no 2656 0.219065242571054 3736 1377347 SGTC_2886 9058944 51.95 µM -0.77556069441736 0.22450678501152 no 2657 0.21900420785692 3658 4949929 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.77575962908352 0.224447658095086 no 2658 0.218945462413985 3802 91467 include heat shock SGTC_1999 st074831 12.5 µM -0.778593914535588 0.223606218551628 no 2659 0.218109482483503 3789 17112523 SGTC_1510 1123-0200 71.5 µM -0.779317544451645 0.223391675928858 no 2660 0.217896341137904 3830 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1674 st016616 23.6 µM -0.779742241774922 0.223265815743688 no 2661 0.217771304753348 3790 625830 SGTC_1521 st012942 49.4 µM -0.779790333319687 0.223251566230379 no 2662 0.217757148589848 3848 24207259 SGTC_444 curcumin 90.4 µM -0.78198642648224 0.222601416116451 no 2663 0.217111275336084 3760 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_737 1950-0117 57.9 µM -0.782654864337892 0.222403740566443 no 2664 0.21691490701307 3747 5393513 SGTC_1897 st060201 15 µM -0.78301051010082 0.22229860710507 no 2665 0.216810470104413 3847 611878 SGTC_1224 0823-0416 294 µM -0.784534229193203 0.221848497249336 no 2666 0.21636335267647 3877 3598164 SGTC_1881 5652484 16 µM -0.785482106185595 0.221568755205339 no 2667 0.216085478813685 3757 2255129 SGTC_1097 itavastatin 7.23 µM -0.787347023732865 0.221018960671442 no 2668 0.215539374723994 3817 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2587 piperic acid 92.2 µM -0.788065606663886 0.220807324499315 no 2669 0.215329165789888 3829 5370536 SGTC_3237 9133362 49.47 µM -0.791232933848717 0.219875871282803 no 2670 0.214404038187725 3753 43845137 SGTC_3081 9117243 49.47 µM -0.79192803039856 0.219671758217882 no 2671 0.214201320890082 3847 45595589 SGTC_2988 9073640 71.4286 µM -0.79200107696175 0.219650314628086 no 2672 0.214180024136879 3854 9102229 SGTC_850 0388-0143 75.9 µM -0.792628300905383 0.219466235897525 no 2673 0.213997207471657 3778 67273 SGTC_117 lucigenin 22.078 µM -0.792880778841133 0.219392163276012 no 2674 0.213923643495811 3843 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_189 3970-0742 2.116 µM -0.79346511863741 0.219220783282613 no 2675 0.21375344209359 3796 2891807 SGTC_3256 9138902 49.47 µM -0.794782610616252 0.218834660859886 no 2676 0.213369984024982 3858 17228773 SGTC_1865 st057639 52.2 µM -0.796334283850545 0.218380408254633 no 2677 0.212918881815609 3818 688818 SGTC_2556 citropten 84.59 µM -0.798534770186941 0.217737147694491 no 2678 0.212280112003645 3867 2775 A potential DNA crosslinker. SGTC_725 1497-0963 19 µM -0.804231273967575 0.216076995398411 no 2679 0.210631710184882 3867 3549977 SGTC_1788 fluconazole 20 µM -0.806066635456274 0.215543675175942 no 2680 0.210102214118839 3891 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2899 9053889 58.44 µM -0.807211820059809 0.215211294016635 no 2681 0.209772228473476 3768 6470052 SGTC_1935 st074532 41.6 µM -0.808827333438619 0.214742909707608 no 2682 0.209307235786931 3862 2829742 SGTC_4 0960-0234 25.671 µM -0.809521879898989 0.214541722698975 no 2683 0.209107511321197 3841 6821112 SGTC_1464 k208-0027 110 µM -0.80969303071748 0.214492162832277 no 2684 0.209058312262172 3817 X1464 SGTC_2382 9035899 200 µM -0.809720624740584 0.214484173098615 no 2685 0.209050380715253 3842 6462679 SGTC_2339 9000433 200 µM -0.809827300356097 0.214453287249092 no 2686 0.209019719848881 3889 2988954 SGTC_657 3534-0529 86.7 µM -0.810625304482025 0.214222322722516 no 2687 0.208790440323305 3865 1049549 SGTC_1604 st002052 72.4 µM -0.81209001707868 0.213798771064763 no 2688 0.208369990505963 3880 6254834 YHR062C RPP1 SGTC_834 0312-0008 75.7 µM -0.812181056819632 0.213772461166614 no 2689 0.208343873791077 3839 6385573 YIL048W NEO1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.812349758918246 0.213723712332722 no 2690 0.208295483057064 3827 4620898 SGTC_1424 4048-1941 275 µM -0.813850452484418 0.213290350988071 no 2691 0.207865314036848 3928 X1424 SGTC_268 camptothecin 39.6153 µM -0.814302621474861 0.213159876835307 no 2692 0.207735804160624 3834 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_845 0330-0138 4.51 µM -0.814425810500442 0.213124338497096 no 2693 0.20770052872322 3782 9039800 SGTC_1741 st038134 10.228 µM -0.815460878679828 0.212825872118324 no 2694 0.207404274572953 3910 1272587 SGTC_522 1273-0010 11.6 µM -0.816120238392634 0.212635870178844 no 2695 0.207215684907032 3980 5705015 SGTC_2301 7769476 200 µM -0.818357810493028 0.211991827444356 no 2696 0.206576452393431 3906 977820 SGTC_3251 9135047 49.47 µM -0.819755016236169 0.211590247529947 no 2697 0.206177889879402 3861 17682963 SGTC_1045 1348-1485 165 µM -0.820702345415858 0.211318223058403 no 2698 0.205907917259645 3877 6810614 SGTC_908 3448-7491 47.7 µM -0.820725570912616 0.211311556457918 no 2699 0.205901301024892 3880 1203031 SGTC_3209 9113616 49.47 µM -0.821512439999885 0.211085767920922 no 2700 0.205677220575061 3828 16649353 SGTC_2947 9072639 7.68 µM -0.823094006468606 0.210632372527089 no 2701 0.205227268441003 3904 16488146 SGTC_2644 guaiazulene 100 µM -0.826051236003903 0.209786143799248 no 2702 0.204387514024707 3869 3515 A coloring agent. SGTC_3057 9095946 49.47 µM -0.82975365717249 0.208729496720152 no 2703 0.203339038705311 3883 24540043 SGTC_1526 st051518 75 µM -0.831670078815823 0.208183796560375 no 2704 0.202797597049981 3880 673993 SGTC_3227 9130768 49.47 µM -0.831780259163289 0.208152448371677 no 2705 0.202766494287719 3902 17720899 SGTC_1422 4031-0024 15.5 µM -0.832152561408516 0.208046542642611 no 2706 0.202661418337652 3823 782427 SGTC_1494 4358-1428 177 µM -0.833951455869624 0.207535274378804 no 2707 0.20215416976343 3887 1564571 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.834135077096731 0.207483128731475 no 2708 0.202102435387677 3879 6708760 SGTC_262 fenpropimorph 62.5 µM -0.835340133484871 0.207141103194991 no 2709 0.201763113338642 3845 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_528 3492-0019 172 µM -0.835785178042967 0.207014872650034 no 2710 0.201637883169634 3878 2869262 SGTC_2357 9067248 200 µM -0.835921995751916 0.206976075406269 no 2711 0.201599393676232 3905 9150235 SGTC_2687 chenodiol 100 µM -0.837672879766155 0.206479959160617 no 2712 0.20110722448453 3950 5702181 A cholesterol synthesis inhibitor. SGTC_1079 idarubicin 2.36 µM -0.838976030372493 0.206111166735749 no 2713 0.200741380249844 3853 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_638 3970-0837 4.09 µM -0.839935955886579 0.205839757203553 no 2714 0.200472148114211 3877 4118451 YLR208W SEC13 SGTC_2640 pentamidine 10.38 µM -0.842019752377629 0.205251314425786 no 2715 0.199888448621384 3904 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_126 0417-1624 672.48 µM -0.842060599000178 0.205239789754291 no 2716 0.199877017154834 3947 41912 YDL195W SEC31 SGTC_2714 st079313 56.9 µM -0.842510832149519 0.205112784185162 no 2717 0.19975103951756 3860 2939799 SGTC_2030 5175110 200 µM -0.842514064721297 0.205111872482926 no 2718 0.199750135199469 3952 2831986 SGTC_1365 1672-3266 55.4 µM -0.842938138793535 0.2049922891294 no 2719 0.199631521028838 3904 6415873 SGTC_3190 9110366 49.47 µM -0.843086991670124 0.204950324389833 no 2720 0.199589896701561 3877 17123768 SGTC_1884 5633444 25 µM -0.843914837258774 0.204717030605893 no 2721 0.19935849822942 3926 5724239 SGTC_1350 1495-0454 146 µM -0.844164855529157 0.204646604443457 no 2722 0.199288645173701 3926 1069057 SGTC_25 0118-0223 35.662 µM -0.844291452488393 0.204610949595219 no 2723 0.199253280642678 3894 5333628 SGTC_1908 st060353 56.5 µM -0.844401767477152 0.204579883425281 no 2724 0.199222467519526 3936 4227716 SGTC_2774 tamoxifen 10.92 µM -0.847037601397713 0.203838432495129 no 2725 0.198487081629899 3911 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1294 1000-1494 117 µM -0.847122232161455 0.203814652724032 no 2726 0.198463497191324 3879 712797 YDL207W GLE1 SGTC_3319 9138450 16.7555 µM -0.849948468844667 0.203021479450309 no 2727 0.197676868318764 3842 2029690 SGTC_892 0929-0076 29 µM -0.849983992049716 0.203011521732965 no 2728 0.197666993121204 3884 5751038 SGTC_3350 9150499 3.57 µM -0.851004227895716 0.202725657947644 no 2729 0.197383502103136 3872 4910996 YPR165W RHO1 SGTC_1794 st048918 76.9 µM -0.853746919429522 0.201958366087462 no 2730 0.196622615489187 3805 672303 SGTC_517 1365-0151 113 µM -0.856648869566256 0.20114841586158 no 2731 0.195819484436822 3992 768657 SGTC_212 3807-4682 38.772 µM -0.856920388736973 0.20107273315456 no 2732 0.195744441963601 3989 3125501 YBL034C STU1 SGTC_3068 9116768 49.47 µM -0.857058408444272 0.201034268367648 no 2733 0.195706302767079 3863 41904888 SGTC_1707 st032323 6.317 µM -0.857423517824936 0.200932537120308 no 2734 0.195605433286199 3798 3132057 YMR211W DML1 SGTC_1569 carminic acid 40.6 µM -0.858554065114465 0.200617726137892 no 2735 0.19529329503856 3984 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1343 1487-0095 224 µM -0.858908056416503 0.200519215012529 no 2736 0.195195622123954 3900 4560101 YGL055W OLE1 SGTC_1401 3807-4679 7.6 µM -0.859235027598689 0.200428249044514 no 2737 0.195105430952248 3860 3291456 SGTC_2763 lisinopril 49.32 µM -0.859592396996901 0.200328854408901 no 2738 0.195006883766493 3824 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2386 9075165 157.42 µM -0.85974289203447 0.200287006303887 no 2739 0.194965392732825 3877 16452277 SGTC_1540 guanosine 70.6 µM -0.860144155553217 0.200175452766822 no 2740 0.194854791813806 3806 6802 Guanosine is a purine nucleoside SGTC_1654 st012436 41.8 µM -0.863390969069248 0.199274194402329 no 2741 0.193961271539003 3859 4323132 SGTC_2701 st077767 14.721 µM -0.865573991124078 0.198669602016406 no 2742 0.193361911852072 3904 5721188 SGTC_3197 9113331 49.47 µM -0.866438368963228 0.198430516851981 no 2743 0.193124905227123 3922 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2611 pyromycin 23.93 µM -0.867592011339511 0.198111692303182 no 2744 0.19280886064609 3929 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1505 k297-0037 20.6 µM -0.869750259489216 0.197516062680298 no 2745 0.192218449720678 3939 4089396 SGTC_570 0987-0065 62.6 µM -0.869993575839888 0.197448980628854 no 2746 0.192151957474575 3739 3104428 SGTC_2508 celastrol 40.54 µM -0.870098892368867 0.197419949249652 no 2747 0.192123181477086 3868 122724 Celastrol is a natural product and antioxidant. SGTC_1898 st060199 18.6 µM -0.872179132847441 0.196847042803828 no 2748 0.191555330730335 3904 688866 SGTC_1993 st073995 70.8 µM -0.872569583065937 0.196739623585321 no 2749 0.191448862840608 3915 3098394 SGTC_2016 5121758 140 µM -0.873475742649921 0.196490461157569 no 2750 0.19120191118146 3880 2795203 SGTC_2283 7944793 200 µM -0.880024672234298 0.194695423791521 no 2751 0.189422972029884 3977 2970533 SGTC_261 5-fluorouridine 15.376 µM -0.880144596173322 0.194662646377401 no 2752 0.189390491374755 3933 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2602 kawain 100 µM -0.880230883516371 0.194639064539536 no 2753 0.18936712310373 3907 5369129 SGTC_2738 aclarubicin 5.55 µM -0.881048750115351 0.194415632600547 no 2754 0.189145717250245 3886 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3248 9135562 49.47 µM -0.881489201620458 0.194295370924009 no 2755 0.189026548052885 3949 17650701 SGTC_475 α-linolenic acid 10 µM -0.882768758609783 0.193946255401595 no 2756 0.188680611675486 3967 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_641 4092-0595 30 µM -0.882845813289894 0.193925243941297 no 2757 0.188659791917983 3969 786260 SGTC_1382 3002-2117 298 µM -0.884913342317091 0.193361983129836 no 2758 0.188101685676959 4009 1497314 SGTC_2933 9026794 32.47 µM -0.885393015180821 0.193231447756209 no 2759 0.187972349152093 3935 17586027 SGTC_2196 6573537 42.6665 µM -0.88598447530295 0.193070565318902 no 2760 0.187812946492719 3973 2903087 SGTC_2895 9054447 58.44 µM -0.886006316771671 0.193064625810544 no 2761 0.187807061662188 3984 2697450 SGTC_2182 6325192 200 µM -0.886311680610532 0.192981597699918 no 2762 0.187724798240296 3863 736248 SGTC_2027 5150920 200 µM -0.887334472434346 0.19270366053427 no 2763 0.187449425631284 3914 786715 SGTC_671 0560-0003 407 µM -0.887497878889124 0.192659278542681 no 2764 0.187405453835797 3853 3238678 SGTC_1799 st045822 46.1415 µM -0.888750838516687 0.192319176208598 no 2765 0.187068501073779 3890 3674992 SGTC_866 0495-0101 262 µM -0.889622362360136 0.192082827155986 no 2766 0.18683434724703 3904 635694 SGTC_142 0335-0849 62.6745 µM -0.892772031649245 0.191230149344568 no 2767 0.185989633424452 3965 3889043 YPR107C YTH1 SGTC_1877 wortmannin 25 µM -0.892784965574496 0.191226652665763 no 2768 0.185986169547504 3970 312145 A covalent inhibitor of PI 3-kinase. SGTC_392 N-ethylmaleimide 8.33 µM -0.896234716853895 0.190295414374123 no 2769 0.185063708772971 3900 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2709 st078560 56 µM -0.89691650029917 0.190111701512903 no 2770 0.184881737355015 3944 17250903 SGTC_1242 0402-0103 60.1 µM -0.896929606186431 0.190108171078278 no 2771 0.184878240417731 3897 432868 SGTC_2938 9059746 27.26 µM -0.897502775343315 0.189953811464027 no 2772 0.18472534656563 3991 6471769 SGTC_3048 9093155 49.47 µM -0.897682640953107 0.189905387922941 no 2773 0.184677383315689 3889 25236002 SGTC_1125 tnp00248 1.32998 µM -0.897831026402825 0.18986544520543 no 2774 0.184637820444642 4066 24207736 SGTC_34 0469-0683 81.75 µM -0.900070151751615 0.189263339819139 no 2775 0.184041459589668 3937 3690923 SGTC_88 0180-0332 8.668 µM -0.901317450833334 0.188928448923435 no 2776 0.18370977895883 4034 3101745 SGTC_1246 0422-0085 105 µM -0.901376667374159 0.18891255878812 no 2777 0.183694041416093 4013 264295 SGTC_1755 st041960 45.185 µM -0.901398984675074 0.188906570389018 no 2778 0.183688110529784 4039 2257073 SGTC_1614 st002383 48.6 µM -0.901737868829024 0.188815652010801 no 2779 0.183598065761497 3967 1947235 SGTC_1809 st050081 57.6 µM -0.904512026550296 0.188072394499178 no 2780 0.18286198007903 4056 5036894 SGTC_2531 methyl deoxycholate 70.07 µM -0.906889432755917 0.187436874472862 no 2781 0.182232634911987 3924 16667744 Haematoxylin. SGTC_3116 9124943 49.47 µM -0.908514391222248 0.187003260786421 no 2782 0.181803256932462 3961 41905195 YPL160W CDC60 SGTC_648 0375-0473 33.3 µM -0.909737839791332 0.186677198284059 no 2783 0.181480391649654 3959 1713139 SGTC_2823 7987624 58.44 µM -0.910839984806365 0.186383766066046 no 2784 0.181189845600724 3985 2239440 SGTC_2063 5246145 200 µM -0.911559040480718 0.186192480659802 no 2785 0.181000446207897 4029 711240 SGTC_1500 4488-1866 171 µM -0.912030859423545 0.186067032062413 no 2786 0.180876236445811 4051 2900003 SGTC_3073 9114972 49.47 µM -0.912964026826731 0.185819073126872 no 2787 0.180630730717978 3973 41905075 SGTC_72 0744-0168 198.391 µM -0.916027125308715 0.185006595614828 no 2788 0.179826333996684 3890 677577 SGTC_986 1493-0483 84 µM -0.917393157376974 0.18464497252639 no 2789 0.179468328539918 3910 40079 SGTC_2831 7999036 19.48 µM -0.917812928719644 0.184533936820192 no 2790 0.179358406219958 4060 2988270 SGTC_394 menadione 8.33 µM -0.921227966309141 0.183632152903525 no 2791 0.178465710088947 3988 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2024 5144227 134 µM -0.921735281208065 0.183498424631918 no 2792 0.178333336361992 4075 3475211 SGTC_3250 9135583 49.47 µM -0.924151908404918 0.182862235012077 no 2793 0.177703615202232 4019 7699353 SGTC_2282 7944268 200 µM -0.924232861458088 0.182840947559424 no 2794 0.177682544889279 4026 2970414 SGTC_375 3970-0961 9.27 µM -0.924455204043371 0.18278248820812 no 2795 0.177624682077744 3957 2898222 SGTC_2890 9046729 58.44 µM -0.925777842059054 0.182434975234871 no 2796 0.177280722314352 3933 903329 SGTC_1796 st049173 110.4 µM -0.926068149977919 0.182358754335833 no 2797 0.177205282368701 3922 94134 SGTC_2350 9023895 38.85 µM -0.926888914864213 0.182143368613277 no 2798 0.176992106623373 4027 2997209 SGTC_1200 1643-0193 18.4 µM -0.928170634897139 0.181807336914922 no 2799 0.176659532106405 4000 5403974 SGTC_2702 st077768 96.8 µM -0.932123049647833 0.180773566394024 no 2800 0.175636468638141 4009 6484119 SGTC_710 3448-4187 58 µM -0.932130750805341 0.180771555728054 no 2801 0.175634478902411 3985 3946412 SGTC_2809 7964133 12.99 µM -0.93289079980421 0.18057318639515 no 2802 0.175438176528591 4020 1253665 SGTC_746 1095-0025 46.6 µM -0.933824552499928 0.180329668153393 no 2803 0.175197201139163 4040 6749286 SGTC_3097 9117246 49.47 µM -0.935683567663499 0.179845459753714 no 2804 0.174718066799475 4031 16423892 SGTC_1663 st014140 55.4 µM -0.935991449859615 0.179765346112461 no 2805 0.174638794974046 4090 4207120 SGTC_2791 5663188 71.43 µM -0.938259959533036 0.179175751407155 no 2806 0.174055415711578 4064 54690634 SGTC_136 0097-0015 404.482 µM -0.939801243186481 0.178775860407111 no 2807 0.173659760517729 4014 4861337 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.940859788059703 0.178501543241928 no 2808 0.173388358493735 4008 2346 DNA damaging agent; causes G2/M arrest. SGTC_2478 5763493 32.33 µM -0.941127825567614 0.17843212461081 no 2809 0.173319678790171 3952 1365576 YLR208W SEC13 SGTC_1320 1313-0481 95.3 µM -0.941618730157908 0.178305030074287 no 2810 0.173193938394045 4017 6813365 YLR208W SEC13 SGTC_1646 st011709 75.6 µM -0.942192274207202 0.17815661257125 no 2811 0.173047104317369 3939 5757843 SGTC_2367 9070478 135.38 µM -0.942870696214615 0.177981156088181 no 2812 0.172873522650949 3972 572802 SGTC_898 1000-0849 28.3 µM -0.943191931551609 0.177898114817352 no 2813 0.17279136980983 4020 6751807 SGTC_663 1486-0733 13.9 µM -0.945073632967666 0.177412174579035 no 2814 0.17231064270927 4029 722445 YPR165W RHO1 SGTC_3157 9099274 49.47 µM -0.945409964159607 0.177325407043448 no 2815 0.172224808571608 4032 17217662 SGTC_2523 spermine 47.74 µM -0.946263692611325 0.177105280466733 no 2816 0.172007053483626 4038 1103 A DNA binding polyamine. SGTC_382 3229-0966 23.2 µM -0.946895994709786 0.176942358101462 no 2817 0.171845889553149 4048 5722370 SGTC_1156 4092-0367 4.88 µM -0.949559082916326 0.17625721238234 no 2818 0.17116816874715 4037 1357585 SGTC_1829 berberine 14.4 µM -0.949901253552847 0.176169302345807 no 2819 0.171081214914386 4037 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1659 st012954 42.1 µM -0.950111488112552 0.176115302921599 no 2820 0.171027803243785 4014 24207262 SGTC_2184 6075246 200 µM -0.950239324863863 0.17608247276319 no 2821 0.170995330571439 4051 2267320 SGTC_2966 9084041 48.03 µM -0.950473726198812 0.176022285484303 no 2822 0.170935798959972 3939 17741380 SGTC_1623 st003709 20.3 µM -0.95166716150601 0.175716048875936 no 2823 0.170632904264145 3996 16192618 SGTC_1900 st060200 72.8 µM -0.951935444924701 0.175647253596931 no 2824 0.170564861080293 4011 688945 SGTC_3352 9151559 45.5865 µM -0.954797482447614 0.174914410560307 no 2825 0.169840060395576 4039 17159339 SGTC_1795 st049545 62.3 µM -0.955916552733279 0.174628393873734 no 2826 0.169557197739905 3951 5291882 SGTC_1120 ficusin 1.78878 µM -0.95696989240876 0.174359448368449 no 2827 0.169291225834939 4107 6199 A DNA cross-linker. SGTC_1199 1638-0010 4.46 µM -0.957087827829995 0.174329352722741 no 2828 0.169261463414334 4039 3111136 SGTC_3108 9121785 49.47 µM -0.957183544965018 0.174304929332551 no 2829 0.169237310514775 3889 17140271 SGTC_3095 9117207 49.47 µM -0.95752384052329 0.174218116391175 no 2830 0.169151459539378 4017 17015229 SGTC_2073 5212005 126 µM -0.957781641196112 0.17415236705075 no 2831 0.169086439288009 3828 691789 SGTC_2164 5685496 200 µM -0.959715758913311 0.173659593854387 no 2832 0.168599144886663 3947 759046 SGTC_1703 st026983 48.3 µM -0.960243594478351 0.173525266503984 no 2833 0.168466315462313 4063 1104023 SGTC_2110 5483698 200 µM -0.960535082827027 0.173451114823611 no 2834 0.168392991485518 4022 2848765 YHR062C RPP1 SGTC_2785 7756463 72.73 µM -0.961937080640816 0.173094742649184 no 2835 0.168040605344315 4000 2201551 SGTC_1899 st063254 59.6 µM -0.964634433221451 0.172410418645991 no 2836 0.167363973198884 4004 3093813 SGTC_2333 9017922 200 µM -0.968266615246521 0.171491656929314 no 2837 0.166455616648522 4109 3163164 SGTC_1498 4478-3555 97.6 µM -0.968536027912729 0.171423633772825 no 2838 0.16638836744425 3991 3437919 SGTC_155 k072-0202 43.6 µM -0.969136666911533 0.171272042413263 no 2839 0.166238502634653 3947 5857737 SGTC_1269 0831-0796 3.05 µM -0.969264445176287 0.171239804349654 no 2840 0.166206632063074 4084 927758 SGTC_1828 st055811 49 µM -0.970444418353823 0.170942284106718 no 2841 0.165912508594522 4089 5877589 SGTC_852 0418-0143 439 µM -0.972303822964594 0.170474122600823 no 2842 0.165449711262125 4077 5369229 SGTC_960 1222-0186 7.7 µM -0.972948833979544 0.170311913510106 no 2843 0.165289366241494 4103 3126296 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.975453344595651 0.169683010177999 no 2844 0.164667716881481 4063 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3308 9128332 17.569 µM -0.978038995195092 0.169035296745348 no 2845 0.164027518978711 4085 17332805 YDL196W YDL196W SGTC_1882 5615643 20 µM -0.978349162256848 0.168957705748793 no 2846 0.163950831327059 4005 2253075 SGTC_2425 5628681 7.85 µM -0.978386563920048 0.168948350942402 no 2847 0.163941585477051 4131 5714958 SGTC_464 bw-b 70c 158 µM -0.980354488171327 0.168456608207831 no 2848 0.163455583479912 4115 5353454 SGTC_417 st075190 100 µM -0.981608646631754 0.168143701125093 no 2849 0.16314634303174 4077 222757 SGTC_2847 9005661 71.43 µM -0.983985471110361 0.167551720399633 no 2850 0.162561328286545 4057 2991449 SGTC_446 go6976 132 µM -0.984138553657535 0.16751363916801 no 2851 0.162523696474995 4092 3501 A protein kinase C inhibitor. SGTC_2623 humulene 100 µM -0.984424230528397 0.167442588324359 no 2852 0.162453484569738 4093 6187145 An anti-inflammatory. SGTC_2695 st077686 51.995 µM -0.984893355886141 0.167325954042944 no 2853 0.16233822865321 4106 2876092 SGTC_1249 0481-0015 10.2 µM -0.985520873608627 0.167170022020412 no 2854 0.162184141734492 4021 4227577 SGTC_251 melphalan 456.522 µM -0.9856344686377 0.167141804782951 no 2855 0.162156258668774 4095 460612 A DNA alkylator. SGTC_3259 9138485 49.47 µM -0.986235188431305 0.166992635818345 no 2856 0.162008857734878 4068 17646153 SGTC_3026 9090633 49.47 µM -0.987690779722715 0.166631543870124 no 2857 0.161652055743666 4074 25236842 SGTC_3144 9087057 49.47 µM -0.991013534578315 0.165809149874174 no 2858 0.16083948571043 3908 17249618 SGTC_1282 0886-0010 32.4 µM -0.998548859587825 0.163953869230672 no 2859 0.159006642200284 4136 2836211 YNL267W PIK1 SGTC_971 1315-0384 26.7 µM -0.998804704354176 0.163891114745558 no 2860 0.15894465334047 4120 6769120 SGTC_727 3032-0951 202 µM -1.00068094369504 0.163431380666663 no 2861 0.158490541591221 4114 3652836 SGTC_2907 7721985 69.9 µM -1.00180732418705 0.16315578692922 no 2862 0.158218329577354 4126 3267881 SGTC_1859 st055998 20 µM -1.00261879647169 0.162957429680712 no 2863 0.15802241157999 4025 676301 SGTC_2487 5918373 44.05 µM -1.00300166513896 0.162863895269399 no 2864 0.157930028918722 4170 2876279 SGTC_2138 5575593 77.673 µM -1.00442136112465 0.162517369828272 no 2865 0.157587779043458 4070 762213 SGTC_1348 1493-0373 93.8 µM -1.00614892017323 0.162096347443077 no 2866 0.157171969595433 4094 3010129 SGTC_2724 maprotiline 69.64 µM -1.00743485626572 0.161783414297509 no 2867 0.156862924031104 4016 4011 A tricyclic antidepressant. SGTC_66 0109-0187 42.4 µM -1.00985735379868 0.161194968498339 no 2868 0.156281818536927 3998 759417 SGTC_2467 5474540 200 µM -1.01070562694862 0.160989246045357 no 2869 0.156078671544582 4054 5413519 SGTC_2362 9071156 126 µM -1.01073472226732 0.160982192915334 no 2870 0.156071706798691 4136 653133 SGTC_226 1,3-diallylurea 8.28947 mM -1.01119343633889 0.160871020583331 no 2871 0.155961928335903 4045 74537 YKL182W FAS1 SGTC_1421 4029-0249 71.4 µM -1.01214237819533 0.160641197492036 no 2872 0.15573499120588 4164 2894095 SGTC_1032 k061-1018 98.7 µM -1.01270561366713 0.160504889629513 no 2873 0.155600397846664 4212 4005393 SGTC_1591 genipin 88.4 µM -1.01281808508317 0.160477679626114 no 2874 0.155573530348893 4139 442424 A DNA cross-linking agent. SGTC_418 lividomycin a 100 µM -1.0153289744408 0.159871009471178 no 2875 0.154974518602773 4127 72394 An antibiotic. SGTC_3047 9092122 49.47 µM -1.01776561281746 0.159283715688221 no 2876 0.154394678761982 4082 17173831 SGTC_2744 captopril 92.04 µM -1.01799894989833 0.159227549549976 no 2877 0.154339227559211 4138 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2440 5628896 157.78 µM -1.0188327258495 0.159026958876793 no 2878 0.154141193153653 4089 5522048 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.01906723272358 0.158970570818135 no 2879 0.154085524521126 4103 3256 An antibiotic and ribosome inhibitor. SGTC_503 tyrphostin 8 294 µM -1.01926097417593 0.158923994842784 no 2880 0.154039543060641 4112 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_686 1319-0111 510 µM -1.02038703958492 0.15865346269361 no 2881 0.153772469036724 4166 4562600 SGTC_2839 9003951 25.97 µM -1.02068311148498 0.158582382913752 no 2882 0.153702299246678 4169 2990634 SGTC_1332 1480-0653 17.5 µM -1.02102031911633 0.158501452869819 no 2883 0.153622406009185 4109 5749438 SGTC_2597 laccaic acid a 100 µM -1.02203007729116 0.158259272308202 no 2884 0.153383332576691 4130 5491415 A textile dye. SGTC_2923 7992654 58.14 µM -1.02303380975339 0.158018777726095 no 2885 0.153145930204664 4119 2985126 SGTC_2657 nystatin 74.44 µM -1.02684451861598 0.157107916474294 no 2886 0.152246841359543 4142 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_849 0386-0493 241 µM -1.02709112169751 0.157049090944361 no 2887 0.152188779435214 4087 726119 SGTC_1158 4092-0494 91.8 µM -1.02987005815148 0.156387195683355 no 2888 0.151535503969706 4219 1148199 SGTC_2802 7925815 54.55 µM -1.03127687979286 0.156052816248366 no 2889 0.151205498602585 4085 1262923 SGTC_345 1362-0200 395 µM -1.03361355815329 0.155498466444406 no 2890 0.150658429233064 4115 1419823 SGTC_1026 k007-1105 30.6 µM -1.03484117629698 0.155207749497971 no 2891 0.150371544803547 4116 7066794 SGTC_944 3370-0224 231 µM -1.03623617132753 0.154877831159715 no 2892 0.150045987845684 4163 4580514 SGTC_504 lovastatin 124 µM -1.03706654852542 0.154681665850036 no 2893 0.149852421853195 4148 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3323 9138564 53.9225 µM -1.03720072488317 0.154649983926346 no 2894 0.14982116016233 4148 43912313 YNL103W MET4 SGTC_1590 st077108 57.8 µM -1.0393228211531 0.154149481609098 no 2895 0.149327312342621 4153 5489485 SGTC_2312 7706453 155.7 µM -1.03973893308598 0.1540514662366 no 2896 0.149230603626059 4131 976098 SGTC_1635 st007035 42.4 µM -1.04055835397025 0.153858571810127 no 2897 0.149040284034328 4096 3716403 SGTC_2005 4024620 188 µM -1.0407723926538 0.153808212728006 no 2898 0.148990597894362 4114 236743 SGTC_1552 6-methylflavone 10.6 µM -1.0410197338319 0.153750031815457 no 2899 0.148933194821781 4043 689013 SGTC_1354 1498-1681 81 µM -1.04223282179337 0.153464893760222 no 2900 0.148651874700475 4147 5754243 SGTC_427 1354-0053 47.3 µM -1.04588800795194 0.152607855914378 no 2901 0.147806370830524 4211 6813657 SGTC_1444 4112-3581 28 µM -1.04635680589387 0.152498166237559 no 2902 0.147698163699446 4177 2877249 SGTC_778 3456-2434 196 µM -1.04824060218887 0.152057921859274 no 2903 0.147263884119992 4098 5539063 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.04967965857854 0.15172218272533 no 2904 0.146932709532589 4171 5282362 SGTC_2505 galangin 7.89 µM -1.05068676027429 0.151487514055205 no 2905 0.146701239373937 4025 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2195 6536160 144.242 µM -1.05164368725513 0.151264760495577 no 2906 0.146481528077536 4092 3834386 SGTC_59 0330-0160 1.33 µM -1.0569740133726 0.150027955052047 no 2907 0.145261723767196 4113 4293482 SGTC_1861 st057647 17.4 µM -1.06027313380831 0.149265841480267 no 2908 0.144510179010771 4235 688668 SGTC_2502 avocadyne acetate 18.59 µM -1.06132165086905 0.149024170991524 no 2909 0.144271874803212 4084 3952079 SGTC_472 calcifediol 10 µM -1.06234382444892 0.148788824107454 no 2910 0.144039813008985 4212 5283731 A vitamin D metabolite. SGTC_1602 st001878 87.6 µM -1.06307100127756 0.148621549040518 no 2911 0.14387487699156 4161 595405 YLR310C CDC25 SGTC_1641 st009299 47.1 µM -1.06354970705426 0.148511499302583 no 2912 0.143766367985227 4079 4046054 SGTC_575 k072-0246 11.9 µM -1.06412472153035 0.148379381197922 no 2913 0.143636101547291 4242 6796779 SGTC_1901 st060216 58.6 µM -1.06654130388128 0.14782499519403 no 2914 0.143089508881817 4114 688792 SGTC_1459 k035-0031 35.7 µM -1.06900567766513 0.147261075451386 no 2915 0.142533555525287 3927 3877128 YMR208W ERG12 SGTC_2555 cholic acid 100 µM -1.07139384189667 0.146715972105108 no 2916 0.14199619030036 4119 6708657 Influences liver metabolism. SGTC_2764 methyldopa 94.69 µM -1.07395050173709 0.146133911622421 no 2917 0.141422433479547 4164 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1518 st038567 90.8 µM -1.07767052049636 0.145289769597014 no 2918 0.140590409368779 4115 77966 SGTC_1892 st058411 7.36 µM -1.07768477197191 0.145286541990905 no 2919 0.140587228267786 4186 3934738 SGTC_2730 imipramine 71.33 µM -1.08024165276185 0.144708252488864 no 2920 0.140017292276901 4147 3696 A tricyclic antidepressant. SGTC_2932 9016711 44.54 µM -1.08049853980772 0.144650238191444 no 2921 0.139960118338463 4191 7117328 SGTC_2057 5236571 38.335 µM -1.08661765032759 0.143272954664284 no 2922 0.138602910659592 4171 54684039 YBR257W POP4 SGTC_2012 4023501 200 µM -1.08738632472792 0.143100570398729 no 2923 0.138433056143311 4205 3477460 SGTC_1264 0783-0040 158 µM -1.08759600809244 0.143053570775632 no 2924 0.13838674690126 4059 2855798 SGTC_862 0452-0056 10.2 µM -1.08767203183961 0.143036532956567 no 2925 0.138369959421767 4135 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3351 9150312 21.596 µM -1.08831377233934 0.142892765971378 no 2926 0.138228306307964 4104 4904905 SGTC_1174 0739-0097 51.1 µM -1.09035830117697 0.142435388354562 no 2927 0.137777671333062 4211 728447 SGTC_1714 st033236 13.627 µM -1.09170567150178 0.142134512647281 no 2928 0.137481245766153 4228 2916566 SGTC_1219 1469-0211 33.1 µM -1.09179217386166 0.142115210867597 no 2929 0.137462229869273 4217 6822282 SGTC_2380 9035439 200 µM -1.09320097865839 0.141801105702882 no 2930 0.137152783727456 4291 6462575 SGTC_676 falcarinol 140 µM -1.09332315803877 0.141773886930221 no 2931 0.137125969281037 4224 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2177 5811945 192 µM -1.09623874910592 0.141125409537612 no 2932 0.136487153120268 4243 5343475 SGTC_1441 4106-0040 13 µM -1.09647219360016 0.141073574590589 no 2933 0.136436092776507 4184 2904180 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.09707224047994 0.140940397038658 no 2934 0.136304906980705 4243 368090 SGTC_3213 9129884 49.47 µM -1.09801274837036 0.140731827423359 no 2935 0.136099461284061 4186 17190742 SGTC_1559 coumarin 343 70.1 µM -1.09859723063762 0.140602316606177 no 2936 0.135971893101496 4217 108770 A hepatotoxic, DNA x-linker. SGTC_792 4534-1957 155 µM -1.09984561824033 0.140325967230384 no 2937 0.135699696204576 4141 1717904 SGTC_1930 st074634 34.3 µM -1.10241415307763 0.139758544252122 no 2938 0.135140830654397 4089 684253 YOR116C RPO31 SGTC_1360 1598-0022 39.8 µM -1.10306430281733 0.139615165386165 no 2939 0.134999620777359 4228 761525 SGTC_3001 9076041 71.4286 µM -1.10408959733967 0.139389258376757 no 2940 0.134777136680752 4173 16004211 SGTC_694 1315-0438 43.2 µM -1.10716029254801 0.138714168743986 no 2941 0.134112315859977 4199 6793154 SGTC_525 k781-2675 26.7 µM -1.10949042444342 0.138203379851214 no 2942 0.133609336507375 4154 3651118 YDL195W SEC31 SGTC_1645 Cervolide 78 µM -1.109755633272 0.138145324736192 no 2943 0.133552171189569 4200 23173 A fragrance. SGTC_599 1935-0052 86.5 µM -1.11009561703356 0.138070925459723 no 2944 0.133478912865722 4190 9557311 SGTC_806 3966-4455 5.86 µM -1.11026262843435 0.13803438805574 no 2945 0.133442936050727 4179 714982 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.11030541392446 0.138025028853289 no 2946 0.133433720473843 4274 4213774 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.11181916638331 0.137694178392064 no 2947 0.133107954679117 4235 688798 SGTC_3204 9114183 49.47 µM -1.11379273311009 0.137263642875005 no 2948 0.132684057607348 4189 17027248 SGTC_872 0588-0139 234 µM -1.11410550213554 0.137195496498402 no 2949 0.132616964244165 4165 2047100 SGTC_1666 st014829 29 µM -1.11541806353675 0.136909766538805 no 2950 0.13233565619107 4186 3858230 SGTC_3306 9127676 59.7925 µM -1.11580200807246 0.136826263038329 no 2951 0.132253447033963 4197 41905287 SGTC_2109 5483026 200 µM -1.11582443068287 0.136821387455786 no 2952 0.132248647054018 4219 759335 SGTC_1322 1348-1070 12 µM -1.1160697534329 0.136768052123447 no 2953 0.132196138966698 4197 6758089 SGTC_282 k297-0036 65.7 µM -1.11609715323045 0.136762096047983 no 2954 0.132190275295133 4204 5061378 SGTC_1995 st072814 61.1 µM -1.11808232903298 0.136331037012704 no 2955 0.131765916413006 4179 5769371 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.118752235791 0.136185784141181 no 2956 0.131622926884799 4231 165521 SGTC_2852 9023854 51.95 µM -1.11945077168536 0.136034436576845 no 2957 0.131473940645311 4261 19798528 SGTC_1969 st069479 40.1 µM -1.12056851804371 0.135792500805503 no 2958 0.131235785951903 4209 3895485 SGTC_2482 5981709 142.65 µM -1.1228809177056 0.135292918666601 no 2959 0.130744036456088 4151 877755 SGTC_2399 5884133 200 µM -1.12745651108987 0.134308101831794 no 2960 0.129774758856167 4205 722445 SGTC_705 1124-0212 310 µM -1.1278009459667 0.134234167972565 no 2961 0.129701996900673 4215 9554485 SGTC_50 0929-0078 56.389 µM -1.12792320624115 0.134207931204049 no 2962 0.129676176182361 4070 1377751 SGTC_1055 3448-0672 86 µM -1.13082884883884 0.133585423582383 no 2963 0.129063567537064 4216 748378 SGTC_146 3448-8650 53.125 µM -1.13227256488536 0.133276860007157 no 2964 0.12875993031313 4198 2891488 YIL048W NEO1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.13324442721018 0.13306942150225 no 2965 0.128555810992879 4207 688803 SGTC_3061 glucosamine 200 µM -1.1388773002791 0.131871494112394 no 2966 0.127377167335877 4166 91431 and experimental redox chemotherapeutic SGTC_2754 granisetron 64.02 µM -1.13926354118377 0.131789626743015 no 2967 0.127296625074146 4243 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_74 000s-0487 160.283 µM -1.13932670210498 0.131776242532113 no 2968 0.127283457588868 4114 677548 SGTC_1807 st050092 58.9 µM -1.1398997955017 0.131654843165268 no 2969 0.127164025132617 4252 5008496 SGTC_1565 sinapyl alcohol 95.1 µM -1.14190103851309 0.13123152183133 no 2970 0.126747578463301 4257 5280507 A phenol propionate derived from cinnamic acid. SGTC_169 k015-0017 16.025 µM -1.14652217187703 0.130257611632544 no 2971 0.125789579290924 4219 1840002 SGTC_742 0kpi-0133 140 µM -1.1486495212061 0.129810954929548 no 2972 0.125350264189604 4270 2728852 SGTC_2655 perillic acid 100 µM -1.15051917634603 0.129419280066338 no 2973 0.12496505031371 4261 5702197 An apoptosis inducer. SGTC_2851 9015922 71.43 µM -1.15137592643181 0.129240073000665 no 2974 0.124788806629888 4266 2996893 SGTC_1691 st019933 84.6 µM -1.15227930986599 0.129051297985154 no 2975 0.12460315812396 4235 6176082 SGTC_2517 totarol 10 µM -1.15353743688872 0.128788712860118 no 2976 0.124344930351632 4254 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1609 st001574 46.4 µM -1.15543015090817 0.128394380992406 no 2977 0.123957160433812 4223 3960012 SGTC_681 1642-0006 26.6 µM -1.16319474821717 0.126785465460351 no 2978 0.122375248423401 4264 4446530 SGTC_2845 9003024 42.97 µM -1.16429224729276 0.126559188109711 no 2979 0.122152798653481 4309 2990173 SGTC_2580 diallyl disulphide 81.36 µM -1.16601161197069 0.126205263160091 no 2980 0.121804875326909 4234 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_199 4063-0024 41.6 µM -1.17642717970798 0.124076004745494 no 2981 0.119712107947083 4280 306215 SGTC_2940 9060638 45.86 µM -1.17950422764714 0.123451800361258 no 2982 0.119098727131761 4263 4027022 SGTC_236 1509-0011 5.31 µM -1.18069822721578 0.123210181153855 no 2983 0.118861313009097 4318 3107280 SGTC_2699 st077704 54.6 µM -1.18332969563623 0.122678844547864 no 2984 0.118339254126715 4275 645852 SGTC_3185 9108267 49.47 µM -1.18509315517457 0.122323673871327 no 2985 0.117990308548269 4275 4910486 SGTC_560 2332-1943 155 µM -1.18567918723977 0.122205803651109 no 2986 0.117874508406199 4245 21177716 SGTC_92 0063-0024 660.874 µM -1.18606856798925 0.122127530549588 no 2987 0.117797611111386 4356 3594437 SGTC_78 0336-0123 156.75 µM -1.18727954983767 0.121884324657332 no 2988 0.117558685898728 4106 6765896 SGTC_2280 7785178 200 µM -1.18950745111225 0.121437776295866 no 2989 0.11712002034553 4266 2954328 SGTC_422 cantharidin 155 µM -1.19278429392932 0.120783075813308 no 2990 0.116476931369275 4188 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_987 1497-1013 404 µM -1.1930037916381 0.120739309974096 no 2991 0.116433944050368 4288 1676435 SGTC_277 nystatin 15.5 µM -1.19300480188985 0.12073910856493 no 2992 0.1164337462246 4287 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1478 0453-0656 35.7 µM -1.19344757575161 0.120650857577023 no 2993 0.116347065956379 4273 5258496 SGTC_1723 st034307 2.5525 µM -1.19436372399476 0.120468400709803 no 2994 0.116167860254178 4305 867466 SGTC_2285 7945142 200 µM -1.1946676369216 0.120407917423448 no 2995 0.116108455821457 4322 2970608 SGTC_274 sirtinol 40.1 µM -1.19585508086975 0.120171803103273 no 2996 0.115876558436597 4338 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_592 k241-0073 46.5 µM -1.1963480249856 0.120073880757195 no 2997 0.115780387440048 4313 4230158 SGTC_1649 st011737 51.3 µM -1.19669320105847 0.120005345715978 no 2998 0.115713079021195 4279 1761035 SGTC_468 gf-109203x 121 µM -1.20167858313307 0.119018567174735 no 2999 0.114744041005657 4302 2396 A protein kinase C inhibitor. SGTC_1017 4239-0030 168 µM -1.20209304897796 0.118936788841951 no 3000 0.114663739587383 4295 1149593 SGTC_1758 st042942 75.2445 µM -1.20245397832108 0.118865606136904 no 3001 0.114593843275706 4259 669317 SGTC_724 3910-0327 137 µM -1.2070422384634 0.117963328434283 no 3002 0.113707938881413 4333 2885483 SGTC_1840 st055363 71 µM -1.20744454597038 0.117884446647825 no 3003 0.113630494508886 4333 676033 SGTC_699 0375-0592 111 µM -1.20792314975017 0.117790653811911 no 3004 0.113538412055695 4365 762578 SGTC_1010 4112-3296 15.2 µM -1.2101338896953 0.117358096518564 no 3005 0.113113760427107 4336 704384 SGTC_2044 5102272 200 µM -1.21067620830736 0.117252157543053 no 3006 0.113009762085281 4293 592666 SGTC_647 0140-0236 81 µM -1.21084525772713 0.117219148515934 no 3007 0.112977358088006 4307 990837 SGTC_3113 9123498 49.47 µM -1.21118849012194 0.117152148322528 no 3008 0.112911586477875 4400 8897275 SGTC_114 0364-0001 490.298 µM -1.21170828144007 0.117050734856861 no 3009 0.112812033962655 4328 4003655 SGTC_3183 9108214 49.47 µM -1.21279160647807 0.116839573561652 no 3010 0.112604752652727 4238 4974831 SGTC_2260 7964312 200 µM -1.21391441969169 0.116621000366066 no 3011 0.112390202969004 4350 231951 SGTC_2977 9011197 71.43 µM -1.21628262967607 0.116160942267108 no 3012 0.111938638101475 4365 2704722 SGTC_1996 st072960 66.8 µM -1.21722875363016 0.115977504937602 no 3013 0.111758596513537 4320 1719405 SGTC_2187 6125751 200 µM -1.2204017694541 0.115363812847385 no 3014 0.111156303459123 4306 874498 SGTC_574 1315-0397 40 µM -1.22112087138318 0.115225052928081 no 3015 0.111020129185462 4288 6794277 SGTC_2575 plumbagin 510 nM -1.22250640051904 0.114958031976792 no 3016 0.110758092472716 4209 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1492 4158-0558 28.5 µM -1.2225598351142 0.114947742814284 no 3017 0.110747995594986 4313 3967268 SGTC_2058 5236698 133 µM -1.22267822754305 0.114924947951653 no 3018 0.110725626784624 4267 766665 SGTC_1760 st045453 10.4495 µM -1.22577723825756 0.114329418520372 no 3019 0.110141257505325 4347 3323419 YIL048W NEO1 SGTC_2444 5485484 36.41 µM -1.22736618538701 0.114024927936775 no 3020 0.109842494889553 4379 6790631 SGTC_176 1486-1328 72.834 µM -1.22922288709803 0.113669859927446 no 3021 0.109494125031831 4369 22310231 SGTC_1106 tegaserod maleate 11.7 µM -1.23167453474822 0.11320222538062 no 3022 0.109035343024262 4332 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2112 5488546 200 µM -1.23183780968861 0.113171130654835 no 3023 0.109004838184122 4265 600757 SGTC_1061 3448-9325 110 µM -1.23541658133601 0.112491105349463 no 3024 0.108337752418504 4276 723482 SGTC_2334 9017922 200 µM -1.23637830840526 0.112308860064786 no 3025 0.108158987625069 4359 3163164 SGTC_2850 9015429 58.44 µM -1.23684301789948 0.112220874224259 no 3026 0.108072684054411 4329 6457570 SGTC_3254 9136651 49.47 µM -1.23774984035777 0.11204932274716 no 3027 0.107904416223248 4261 16454030 SGTC_2390 9097792 176.6 µM -1.23793843839202 0.112013667583376 no 3028 0.10786944413173 4351 4497149 SGTC_2453 5731132 22.18 µM -1.24030032653942 0.111567830565973 no 3029 0.107432165842515 4363 1362040 SGTC_224 benfluorex 43.875 µM -1.24393309616464 0.110884578918086 no 3030 0.106762093673535 4344 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_581 0958-0271 211 µM -1.2457606702047 0.110541984215572 no 3031 0.106426136273202 4325 4591145 SGTC_1724 st037281 8.293 µM -1.24608857818287 0.110480595372461 no 3032 0.106365938798719 4288 574124 YDL195W SEC31 SGTC_533 1222-0222 6.71 µM -1.24707804178211 0.110295502454697 no 3033 0.106184441731977 4356 3982874 SGTC_194 1486-1323 56.904 µM -1.26064472044092 0.107780066505916 no 3034 0.103718439374223 4428 5178754 SGTC_2797 7859098 81.82 µM -1.26214844730009 0.107503821070502 no 3035 0.103447687521169 4313 972681 SGTC_2384 9036245 200 µM -1.26272753915907 0.107397573938146 no 3036 0.103343556726731 4264 6462766 SGTC_350 k064-0020 19.8 µM -1.26312376323297 0.107324921545407 no 3037 0.103272352600825 4357 2790705 SGTC_2572 astragaloside iv 100 µM -1.26869011899483 0.106308007210264 no 3038 0.1022758040001 4360 45006101 An anti-inflammatory agent. SGTC_2136 5328288 199.296 µM -1.26927902841412 0.106200828112573 no 3039 0.102170781676214 4331 262395 SGTC_258 haloperidol 50.781 µM -1.26971355243029 0.10612179658257 no 3040 0.102093341766877 4339 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1508 1080-0625 72.9 µM -1.27118757322738 0.105854017207584 no 3041 0.101830963195958 4256 767111 SGTC_3173 9105693 49.47 µM -1.27472464634855 0.105213444296339 no 3042 0.101203360056171 4336 17096658 SGTC_927 2425-1185 123 µM -1.27674731726163 0.10484839649124 no 3043 0.100845735189933 4272 730375 SGTC_1159 4092-0538 61.2 µM -1.2778591540184 0.104648125332104 no 3044 0.10064954620883 4369 717301 SGTC_2188 6126565 140.678 µM -1.28085061373163 0.104110660415797 no 3045 0.100123071133351 4250 874518 SGTC_1937 st074714 47.2 µM -1.28096232914606 0.104090627740922 no 3046 0.100103449053251 4297 17250970 SGTC_933 2914-0560 114 µM -1.28237066300149 0.103838326643406 no 3047 0.0998563252007305 4365 463887 SGTC_549 1661-1316 519 µM -1.28371898773374 0.103597192008754 no 3048 0.0996201491119857 4379 2857282 SGTC_1804 st050076 49.1 µM -1.28434980802422 0.103484515625633 no 3049 0.0995097932414064 4371 3895976 SGTC_1793 st048256 72.231 µM -1.28454971152457 0.103448827662282 no 3050 0.0994748407193794 4305 672022 SGTC_3305 9127027 53.8275 µM -1.28707146991868 0.102999395271866 no 3051 0.0990346892505951 4304 41905295 SGTC_2866 9034245 58.44 µM -1.28980479920984 0.102513860027824 no 3052 0.0985592206122448 4363 6462273 SGTC_1165 k072-0275 30.3 µM -1.29002771250959 0.102474336310818 no 3053 0.0985205181818064 4328 6153523 YGL055W OLE1 SGTC_1412 3909-8563 178 µM -1.29357543086594 0.101846797631994 no 3054 0.097906056772723 4449 23767530 SGTC_1702 st027038 51 µM -1.29651960243558 0.101328145054885 no 3055 0.0973982655257069 4387 5521182 SGTC_3262 9137218 49.47 µM -1.29861450810636 0.100960274759002 no 3056 0.0970381282551723 4314 17650664 SGTC_607 4491-0986 66.8 µM -1.29908883128415 0.10087711785706 no 3057 0.0969567227792638 4366 698981 YDR232W HEM1 SGTC_26 0302-0163 425.158 µM -1.29974376605595 0.100762378777157 no 3058 0.0968444023495441 4424 3100915 SGTC_2403 6032726 181.2 µM -1.30297792645118 0.100197176234575 no 3059 0.0962911488090102 4401 2881040 SGTC_790 1575-0012 79.1 µM -1.30481919505483 0.0998764314143029 no 3060 0.0959772106851029 4405 378741 YLR208W SEC13 SGTC_372 0155-0182 15.9 µM -1.30789498166454 0.0993423101535281 no 3061 0.095454465943201 4251 771486 SGTC_1054 3429-0080 167 µM -1.30897187450356 0.0991557983245839 no 3062 0.0952719390255686 4384 1162877 SGTC_1117 retinoic acid 1.10837 µM -1.31137209518869 0.0987410152205894 no 3063 0.0948660408666194 4412 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1764 st044502 93.5 µM -1.31660825857017 0.0978405612150254 no 3064 0.093984984561475 4395 8407 SGTC_1655 st012546 55.1 µM -1.31740272145462 0.0977044663928804 no 3065 0.0938518345997206 4365 720985 YLR208W SEC13 SGTC_3067 9117431 49.47 µM -1.31741606403181 0.0977021819391345 no 3066 0.0938495996070967 4395 17150885 SGTC_2944 9067346 25.62 µM -1.31867354329473 0.0974870579417365 no 3067 0.0936391376576096 4318 6473075 SGTC_2753 fluvastatin 17.09 µM -1.31972155271329 0.0973080347090718 no 3068 0.0934640007026957 4382 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_888 0916-0002 6.97 µM -1.32087725112517 0.0971108955917469 no 3069 0.0932711480617963 4417 2802138 YIL048W NEO1 SGTC_967 1306-0166 352 µM -1.32105171151398 0.0970811616086694 no 3070 0.093242061228581 4393 4437607 SGTC_3052 9092717 49.47 µM -1.3213781175722 0.0970255488635071 no 3071 0.0931876593204861 4387 25237534 SGTC_1423 4048-0112 5.59 µM -1.32450946246965 0.0964932212363752 no 3072 0.0926669512765024 4445 X1423 SGTC_2999 9069765 71.4286 µM -1.32632661922516 0.0961852907751271 no 3073 0.0923657666614765 4331 2097066 SGTC_1405 3909-7894 12 µM -1.33143867531551 0.095322891220059 no 3074 0.0915223553744607 4360 7104060 SGTC_1377 2944-0135 198 µM -1.33455362121343 0.0948002012816267 no 3075 0.0910112429994115 4396 1894137 SGTC_1739 st037196 92.5 µM -1.33683793288309 0.0944182367596899 no 3076 0.0906377721135087 4423 612214 SGTC_2003 4023581 200 µM -1.33799119723896 0.0942258286579925 no 3077 0.0904496531736459 4412 16641307 SGTC_316 k060-0003 58.6 µM -1.33986612631931 0.0939136371604628 no 3078 0.0901444362599989 4428 6152314 SGTC_463 ikarugamyin 104 µM -1.34262441370765 0.0934557476521451 no 3079 0.0896968104949068 4537 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.34362181706894 0.0932905802976717 no 3080 0.0895353554229514 4387 688662 SGTC_2876 9059903 25.97 µM -1.34570741020999 0.092945908756221 no 3081 0.0891984478172969 4386 6916095 SGTC_456 gingerol 170 µM -1.34797560039743 0.0925721303105658 no 3082 0.0888331152290726 4442 442793 A herb. SGTC_1493 4348-0038 111 µM -1.34841396966018 0.0925000191842054 no 3083 0.0887626366722516 4375 800424 SGTC_856 0433-0016 11.3 µM -1.35326833054511 0.0917042601282932 no 3084 0.0879849613591893 4435 3911780 SGTC_731 3966-0296 387 µM -1.36023995014237 0.0905703146162426 no 3085 0.0868770020805733 4404 660956 SGTC_1407 3909-7909 12.3 µM -1.36720270491904 0.0894482330734053 no 3086 0.0857808888769661 4430 4411780 SGTC_1820 st053765 18.6 µM -1.3729451663582 0.0885306147314961 no 3087 0.0848846969476008 4451 3690829 SGTC_2862 9027634 71.43 µM -1.37499554725127 0.088204678246155 no 3088 0.0845664125841168 4376 5012562 SGTC_739 1486-1183 203 µM -1.37547634053965 0.0881283791074516 no 3089 0.0844919079036449 4422 4346692 SGTC_1080 nisoldipine 24.4 µM -1.37684346174351 0.0879116936846713 no 3090 0.0842803251913829 4428 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_689 0833-0039 98 µM -1.38340422153012 0.086877355266865 no 3091 0.0832704784302616 4388 5374726 SGTC_3018 9082602 49.47 µM -1.38891210866012 0.0860160508470263 no 3092 0.0824297390075082 4355 17332089 SGTC_2201 6605497 169.863 µM -1.39562102910478 0.084975583268324 no 3093 0.0814143232136116 4369 670741 SGTC_883 0850-0245 24.6 µM -1.40089848192507 0.0841637696018128 no 3094 0.0806222164041491 4489 6823229 YPR165W RHO1 SGTC_3039 9090270 49.47 µM -1.40203283068367 0.0839900390152083 no 3095 0.0804527215597463 4444 17173750 SGTC_1938 st074717 56.4 µM -1.40746017443154 0.0831625417485975 no 3096 0.0796454893223757 4308 17250979 SGTC_104 0074-0074 590.992 µM -1.41024757067781 0.0827399424917923 no 3097 0.07923329686801 4295 3943124 SGTC_3148 9097893 49.47 µM -1.41083898211211 0.0826504863273432 no 3098 0.0791460486396574 4405 17174100 SGTC_665 3914-0008 307 µM -1.41122757139578 0.0825917484305236 no 3099 0.0790887614530802 4398 1069549 SGTC_414 piperonyl butoxide 100 µM -1.41228308452933 0.0824323590751426 no 3100 0.0789333125204665 4450 5794 A potent inhibitor of cytochrome P450. SGTC_195 4234-0266 16.654 µM -1.41252705408738 0.0823955510562841 no 3101 0.0788974152635059 4462 2303354 SGTC_955 1216-0110 33 µM -1.41276973844348 0.0823589492166218 no 3102 0.0788617193799218 4413 3619719 SGTC_711 k292-0785 179 µM -1.41279154280709 0.0823556612653936 no 3103 0.0788585128253678 4381 4146315 SGTC_47 0149-0135 24.25 µM -1.41375467769083 0.0822105255992237 no 3104 0.078716972518395 4460 5239155 SGTC_961 1252-1571 372 µM -1.41388049290906 0.0821915806256548 no 3105 0.0786984972001255 4461 6813498 SGTC_3324 9138759 60.749 µM -1.41518214455399 0.0819957737943788 no 3106 0.0785075491609624 4472 45595710 SGTC_188 3229-0966 278.469 µM -1.41526729602717 0.0819829767582922 no 3107 0.0784950699682959 4499 5722370 SGTC_54 0159-0055 9 µM -1.42503839949077 0.0805244940260944 no 3108 0.0770730507303477 4434 3319099 SGTC_1953 st076800 12.1 µM -1.42644866131915 0.0803156202122008 no 3109 0.0768694379804207 4438 297591 SGTC_81 0411-0046 9.971 µM -1.4294371934861 0.079874342352806 no 3110 0.076439307337504 4441 12925265 SGTC_2457 5731572 11.68 µM -1.4307284126087 0.0796842529634509 no 3111 0.0762540334441257 4499 2865357 SGTC_1427 4048-4900 550 nM -1.43122864017524 0.0796107030120818 no 3112 0.0761823489234472 4438 24132586 SGTC_2025 5147754 141 µM -1.43638878287284 0.0788549870893775 no 3113 0.07544587160412 4423 315777 YLR208W SEC13 SGTC_956 1185-0240 191 µM -1.43640895030275 0.0788520442178032 no 3114 0.07544300390635 4437 1416193 SGTC_1468 k284-1086 134 µM -1.43848148832546 0.0785500587750018 no 3115 0.0751487430879418 4459 15996457 SGTC_1687 st020778 55.3625 µM -1.43969316903583 0.0783739137020778 no 3116 0.0749771134213827 4472 4259299 SGTC_3320 9137005 35.139 µM -1.4416547553406 0.0780893881005202 no 3117 0.0746998966770798 4508 4908713 SGTC_2061 5245884 80.95 µM -1.44285838895201 0.0779151909054417 no 3118 0.0745301835044713 4428 573863 SGTC_1071 trifluoperazine 6.31 µM -1.44384586619443 0.0777724975061638 no 3119 0.0743911684434997 4513 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2878 9043973 25.97 µM -1.44434442818894 0.077700529211309 no 3120 0.0743210571403165 4478 6465167 SGTC_3084 9116877 49.47 µM -1.44716450204441 0.077294398057879 no 3121 0.0739254280250321 4418 27241325 SGTC_859 0439-0102 54.6 µM -1.44790516987663 0.0771879991054516 no 3122 0.0738217867978595 4510 610143 SGTC_191 3914-0123 66.505 µM -1.45245023878982 0.076537522825805 no 3123 0.073188227944066 4513 3144412 SGTC_1275 0867-0008 21.1 µM -1.45630647110485 0.0759889075524077 no 3124 0.0726539587291473 4444 3422836 SGTC_1116 jasmonic acid  1.58368 µM -1.46010515644224 0.075451411813316 no 3125 0.0721305878407492 4515 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1487 3970-0795 2.82 µM -1.46413348004873 0.0748845939878051 no 3126 0.071578740541854 4522 3765103 SGTC_1265 0819-1001 68.8 µM -1.46493676451301 0.0747719548068687 no 3127 0.0714690855676189 4412 3106768 SGTC_1059 3448-6867 171 µM -1.46653677943101 0.0745479807241975 no 3128 0.0712510544750956 4447 3934407 SGTC_1232 0279-0259 161 µM -1.47168189685291 0.0738312248130764 no 3129 0.0705533992099979 4462 1560000 SGTC_100 0086-0128 49.5915 µM -1.47629819168778 0.0731926315341128 no 3130 0.0699319296936501 4482 93297 SGTC_1705 st027868 56.3335 µM -1.48079103478658 0.0725751823288752 no 3131 0.0693311331395472 4412 292948 SGTC_3155 9099265 49.47 µM -1.48087062844708 0.072564279888434 no 3132 0.0693205255903207 4451 25236499 SGTC_3118 9124250 49.47 µM -1.48178809628935 0.0724386991463759 no 3133 0.0691983437170942 4445 1504786 SGTC_545 4218-0007 221 µM -1.48308209862748 0.0722618624010412 no 3134 0.0690262997747 4485 2840508 SGTC_308 4092-1169 104 µM -1.48523016572457 0.0719690409094134 no 3135 0.0687414318422836 4456 2268590 YDL196W YDL196W SGTC_775 4577-0580 57.3 µM -1.4909477468145 0.0711940621558459 no 3136 0.0679876071339786 4510 2006902 SGTC_1621 st003705 32.4 µM -1.49400391736089 0.0707824554497501 no 3137 0.0675872976949489 4493 24207032 SGTC_1731 st035964 63 µM -1.49454299474513 0.0707100422966196 no 3138 0.0675168765176659 4408 6739575 SGTC_2045 5106652 78.05 µM -1.5005776668094 0.0699032981397838 no 3139 0.06673241566232 4490 673349 SGTC_1553 gossypol 38.6 µM -1.50081198723958 0.0698721164994288 no 3140 0.0667020986649029 4411 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2928 9011484 9.79 µM -1.50283329272009 0.0696035802836861 no 3141 0.0664410191753377 4493 2994751 SGTC_1188 1403-0014 4.57 µM -1.50415519635684 0.0694283918218558 no 3142 0.066270705444354 4513 9614867 SGTC_451 chloral hydrate 100 µM -1.50485718664051 0.0693354970279991 no 3143 0.0661803987478923 4479 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3224 9130643 49.47 µM -1.50531278340052 0.0692752588878824 no 3144 0.0661218400758957 4506 17644395 SGTC_2302 7771753 200 µM -1.50589399866052 0.0691984702417306 no 3145 0.066047193706598 4481 2203047 SGTC_2294 7971431 200 µM -1.50619128208834 0.0691592192884003 no 3146 0.066009038384967 4487 5741572 SGTC_3191 9110352 49.47 µM -1.5063575212045 0.069137277869835 no 3147 0.06598770960373 4450 17122424 SGTC_1534 6-azauridine 81.6 µM -1.50892471819607 0.0687991216186313 no 3148 0.0656590111220868 4529 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.51055010438602 0.0685856827421153 no 3149 0.0654515572931069 4494 688751 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.51213321853759 0.0683782861856024 no 3150 0.0652499878485009 4508 23847180 SGTC_201 4262-0159 12.803 µM -1.51514757101502 0.0679847279085025 no 3151 0.0648675184476357 4555 1341029 SGTC_2174 5790901 200 µM -1.51997812633799 0.0673576936627131 no 3152 0.0642582366104234 4486 786020 SGTC_1486 3970-0793 4.53 µM -1.52052629533104 0.067286821482891 no 3153 0.0641893775569726 4539 2844330 SGTC_841 0251-0215 91.2 µM -1.52092609275201 0.0672351684687356 no 3154 0.064139192597577 4549 3888614 SGTC_2010 4012422 159 µM -1.52111898969866 0.067210257541774 no 3155 0.0641149899320098 4455 952393 SGTC_2522 biochanin a 4.94 µM -1.52154272494112 0.0671555609555839 no 3156 0.0640618490509618 4506 5280373 A possible chelator. SGTC_1192 1488-0095 21.4 µM -1.52163921130526 0.0671431111165473 no 3157 0.0640497534282931 4539 915875 SGTC_1972 st070201 17.4 µM -1.52298014779108 0.0669702719575557 no 3158 0.0638818361101843 4528 2829099 SGTC_1613 st002381 52.1 µM -1.52506883857513 0.0667017372584051 no 3159 0.0636209643075854 4502 551167 SGTC_1428 4049-0204 61.7 µM -1.52947499970144 0.0661379882886404 no 3160 0.0630733660652304 4541 X1428 SGTC_2557 derrustone 83.84 µM -1.52963426011441 0.0661176809465042 no 3161 0.0630536421185484 4487 629853 An antioxidant. SGTC_2035 5154463 94.595 µM -1.53160853076248 0.0658663420177398 no 3162 0.0628095330631492 4527 2769623 SGTC_303 1348-1668 34.2 µM -1.53249683682247 0.0657534960505186 no 3163 0.062699938787475 4530 5380509 SGTC_1797 st048695 56.8 µM -1.54132879241976 0.064639665800263 no 3164 0.0616183924014343 4478 592262 YIL048W NEO1 SGTC_2993 9054257 71.4286 µM -1.54163436191112 0.0646013932244063 no 3165 0.0615812352607036 4439 6470217 YGL055W OLE1 SGTC_2913 7966556 36.57 µM -1.54491271026547 0.0641918867615438 no 3166 0.0611836893182192 4417 2976516 SGTC_946 3434-1334 87.4 µM -1.54526895813238 0.0641475087929712 no 3167 0.0611406103296046 4489 4047976 SGTC_959 1222-0044 107 µM -1.54836741170184 0.0637625380757937 no 3168 0.0607669313099393 4511 6083612 SGTC_1846 st056244 14.8 µM -1.5523765062183 0.0632670937633615 no 3169 0.0602860807720928 4533 5393182 SGTC_2985 9022375 71.43 µM -1.55502381834053 0.0629415851763991 no 3170 0.0599701984034044 4545 4939335 SGTC_1317 1273-0028 910 nM -1.55828464094947 0.0625424354274693 no 3171 0.0595828941074402 4544 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_893 0958-0369 48.9 µM -1.55888527919322 0.0624691283738934 no 3172 0.0595117675507545 4396 6819948 SGTC_891 0929-0073 133 µM -1.56299563468307 0.0619692617913785 no 3173 0.0590268107964238 4544 5603632 SGTC_2448 5185112 27.17 µM -1.56470300489347 0.0617625457309414 no 3174 0.0588262817969709 4530 5718189 SGTC_2755 lomerizine 42.69 µM -1.57644854282443 0.0603550375345305 no 3175 0.0574612343538726 4479 3949 A calcium channel blocker. SGTC_1560 lithocholic acid 53.1 µM -1.58160469448284 0.0597451422341309 no 3176 0.0568699208338953 4478 9903 A bile acid which acts as a detergent. SGTC_2545 solidagenone 89.61 µM -1.58224212783619 0.0596700800032401 no 3177 0.0567971532644969 4477 6708572 An anti ulcer agent SGTC_784 4579-0127 173 µM -1.58326406700809 0.0595498937512187 no 3178 0.0566806446634631 4557 1948547 SGTC_1757 st041620 31.8375 µM -1.58366740751022 0.0595025107091502 no 3179 0.0566347127237166 4546 5289815 SGTC_3215 9129942 49.47 µM -1.58712892531042 0.0590970777610897 no 3180 0.0562417239712337 4506 17682944 SGTC_3286 9117135 37.221 µM -1.5885620201627 0.0589298609897483 no 3181 0.0560796542547434 4483 3438150 SGTC_819 1013-0258 27.7 µM -1.59073808463979 0.0586766629166681 no 3182 0.0558342660754255 4542 5753198 SGTC_1179 1021-1431 9.29 µM -1.59522529709636 0.0581572456209262 no 3183 0.0553309318682417 4557 2840958 SGTC_670 4204-0025 119 µM -1.59811124018847 0.0578250967288351 no 3184 0.0550091112690371 4556 719039 SGTC_2344 7990960 76.95 µM -1.59971762473041 0.0576408618914494 no 3185 0.0548306200762916 4529 140813 SGTC_1201 1889-3372 45.9 µM -1.5997692120044 0.0576349530512818 no 3186 0.0548248956234084 4457 5392199 SGTC_2356 9061756 188.97 µM -1.60369782053733 0.0571863654675855 no 3187 0.0543903382744905 4580 20104043 SGTC_1792 st045773 43.6 µM -1.60829994247307 0.0566643730013905 no 3188 0.0538847516320654 4531 2919270 SGTC_294 k038-0071 157 µM -1.61245235399908 0.0561966167217307 no 3189 0.0534317700453866 4579 24152826 SGTC_1130 3454-2858 15.9 µM -1.62227185322009 0.055102592347581 no 3190 0.0523725763046239 4515 715628 YIL048W NEO1 SGTC_1267 0828-0272 9.49 µM -1.62463030994103 0.0548423508630652 no 3191 0.0521206773858582 4601 745334 SGTC_119 0121-0043 24.815 µM -1.62484704242682 0.0548184845604875 no 3192 0.0520975772754821 4565 1092378 SGTC_2053 5265679 138 µM -1.62542572253334 0.0547548012733681 no 3193 0.0520359393600962 4476 764595 SGTC_127 0180-0333 59.125 µM -1.62576742802182 0.0547172243274167 no 3194 0.0519995699302181 4466 771601 SGTC_655 k060-0012 42 µM -1.63124791308595 0.0541173234092497 no 3195 0.0514190095504296 4546 5994525 SGTC_2074 5212007 75.395 µM -1.63441064337262 0.0537735028965422 no 3196 0.0510863274490172 4493 758611 SGTC_163 TUB2.036 7.546 µM -1.63584771809023 0.053617851123004 no 3197 0.0509357311451645 4516 15992207 YJR013W GPI14 SGTC_2064 5220758 200 µM -1.63654109504011 0.0535428781521523 no 3198 0.0508631961437938 4576 788518 SGTC_2686 alizarin 95.37 µM -1.65180927990213 0.0519129267480043 no 3199 0.0492867181670036 4537 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_756 0508-1999 28.3 µM -1.65595557127737 0.051477166431098 no 3200 0.0488654082363444 4595 6753853 SGTC_3270 9137563 49.47 µM -1.66308849113404 0.0507343335995826 no 3201 0.0481473616533276 4579 17015724 SGTC_2902 5787006 60.46 µM -1.66694859765576 0.0503359106333214 no 3202 0.0477623131731464 4549 591003 SGTC_3260 9137109 49.47 µM -1.66865413626404 0.0501606686515842 no 3203 0.0475929717009293 4559 17478346 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.67055298529977 0.0499661368018407 no 3204 0.047405002726197 4545 364106 SGTC_2534 helenine 20.12 µM -1.67670939156993 0.0493395645689988 no 3205 0.0467996616132681 4581 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2335 9018011 154.17 µM -1.67943164669386 0.0490645129626526 no 3206 0.0465339749652557 4556 6458208 SGTC_3127 9126946 49.47 µM -1.68305355219699 0.04870046276214 no 3207 0.0461823624801785 4536 27243249 SGTC_3140 9094243 49.47 µM -1.68380263720653 0.048625439778937 no 3208 0.0461099086952667 4546 19291112 SGTC_661 1304-0007 33.6 µM -1.68635190820093 0.0483708151140485 no 3209 0.0458640192635967 4597 3117130 SGTC_941 3237-0776 460 µM -1.68911760344856 0.048095780957642 no 3210 0.0455984475050828 4575 760008 SGTC_1145 3546-0597 10.2 µM -1.69097309351505 0.0479119644706845 no 3211 0.0454209708250733 4571 875334 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.69288195147036 0.0477234483375907 no 3212 0.0452389697139833 4459 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3180 9109287 49.47 µM -1.69558800326528 0.0474572208476517 no 3213 0.0449819656475318 4612 18891271 SGTC_1007 4101-0031 70 µM -1.70150700509083 0.0468790437474137 no 3214 0.044423911771531 4583 1146276 SGTC_2630 antimycin a 100 µM -1.70275726380977 0.0467576422518679 no 3215 0.0443067517772868 4523 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1140 3229-1848 2.98 µM -1.7043847991215 0.0465999847882545 no 3216 0.0441546109453368 4588 2849525 SGTC_322 k048-0136 19.3 µM -1.71955948569532 0.0451504750126051 no 3217 0.042756272975945 4639 6823282 SGTC_370 0180-0345 38.7 µM -1.72424795652791 0.0447100345325865 no 3218 0.0423315450397119 4452 3989527 SGTC_2123 5259487 200 µM -1.72651027387087 0.0444987508372543 no 3219 0.0421278263067024 4601 2173474 SGTC_121 0557-0495 61.343 µM -1.73204021024593 0.0439856810104565 no 3220 0.0416332016723144 4625 3104427 SGTC_1911 st060208 74.3 µM -1.73460247209708 0.0437495759955216 no 3221 0.0414056206624757 4612 688783 SGTC_997 3996-0078 137 µM -1.73643529455516 0.0435813148299763 no 3222 0.0412434480567098 4637 735687 SGTC_2496 diffractaic acid 79.83 µM -1.73690378458504 0.0435383893001696 no 3223 0.0412020776520914 4580 94870 An apoptosis inducer which activates caspases. SGTC_1502 4534-4282 27.7 µM -1.74340236281461 0.042946467728045 no 3224 0.0406316779346826 4599 3278949 SGTC_1919 st067113 52.3 µM -1.75395726590916 0.0419989493498403 no 3225 0.0397189149449272 4571 1268243 SGTC_1148 3909-7663 27.7 µM -1.75451768370865 0.0419491173062537 no 3226 0.0396709212565058 4630 4084526 SGTC_3031 9088762 49.47 µM -1.76868404534553 0.0407052717263337 no 3227 0.0384733081402751 4594 205253 SGTC_1516 st013856 110 µM -1.77084226806476 0.0405184281443037 no 3228 0.038293467448739 4621 5281404 A mutagen and neurotoxin. SGTC_2148 5546263 113.568 µM -1.78184187112929 0.0395769498082348 no 3229 0.037387511009437 4656 792097 SGTC_1627 st003713 25.6 µM -1.78325124761646 0.0394576147629003 no 3230 0.0372727067935767 4622 16195070 YER133W GLC7 SGTC_3090 9117696 49.47 µM -1.7832877851719 0.0394545249436515 no 3231 0.0372697343718087 4592 7923821 SGTC_165 k038-0023 64.381 µM -1.79068132609268 0.0388333240227538 no 3232 0.0366722240187725 4584 46368543 SGTC_2529 gangaleoidin 93.61 µM -1.79143955674928 0.0387700708099887 no 3233 0.0366113929655158 4601 4565183 SGTC_1051 3253-3903 78 µM -1.79154448751659 0.0387613238769661 no 3234 0.0366029811240723 4630 5509239 SGTC_700 3453-2283 142 µM -1.79325441593829 0.0386190122085915 no 3235 0.0364661263077478 4652 565664 SGTC_1946 st076057 65.1 µM -1.8031201811176 0.0378062105776955 no 3236 0.0356846711840434 4627 953009 SGTC_571 k831-0106 44.2 µM -1.80389560592583 0.0377429226344339 no 3237 0.0356238369809867 4528 4783639 SGTC_1186 1319-0216 26 µM -1.81250180285951 0.0370462990454634 no 3238 0.0349543478100916 4663 4565136 SGTC_1449 4112-4002 201 µM -1.82147426536299 0.0363312542712298 no 3239 0.0342673975605868 4665 2059539 SGTC_109 0132-0036 33.701 µM -1.8291614515618 0.0357276590633017 no 3240 0.0336877126736604 4570 67274 A color developer. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.82984669242714 0.0356742554763655 no 3241 0.0336364332618355 4624 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_405 ebelactone b 50 µM -1.84180808380988 0.0347525482662383 no 3242 0.0327516135981071 4618 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_493 zm226600 134 µM -1.84283347556259 0.0346744532149054 no 3243 0.032676663790292 4639 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1805 st050013 60.3 µM -1.8492075077985 0.0341922259553494 no 3244 0.0322139275264213 4596 4037144 SGTC_1015 4130-4525 82 µM -1.85274661658415 0.0339268639005237 no 3245 0.0319593424904992 4631 1363237 SGTC_184 1494-0393 24.714 µM -1.85627892156641 0.0336637033570712 no 3246 0.0317069059642601 4628 3090647 SGTC_2642 cholecalciferol 100 µM -1.85633409650816 0.0336596061268795 no 3247 0.0317029759878013 4653 9821465 A vitamin D precursor, similar to steriods. SGTC_938 3126-1755 342 µM -1.85680591588767 0.0336245860982255 no 3248 0.03166938587918 4636 1777771 SGTC_2959 9079155 11 µM -1.85864548549919 0.0334883332898741 no 3249 0.0315387026444667 4644 16189457 SGTC_2151 5563267 85.4165 µM -1.85944174969315 0.033429496898299 no 3250 0.0314822743347249 4683 5310824 SGTC_1650 st011916 45.8 µM -1.86073302531315 0.0333342647840052 no 3251 0.0313909438201796 4630 242528 SGTC_2608 thymoquinone 42.66 µM -1.86347255594619 0.0331329629561306 no 3252 0.0311979051138276 4604 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_666 0272-0154 136 µM -1.86591004790488 0.0329546980178952 no 3253 0.0310269757903372 4644 6870312 SGTC_1058 3448-5425 97.3 µM -1.87725674333517 0.0321352366505427 no 3254 0.0302414568902501 4615 7279705 SGTC_830 4076-0286 57.8 µM -1.88738528287221 0.0314180304623349 no 3255 0.029554261574749 4692 6866659 SGTC_23 0213-0011 39.996 µM -1.88845623800596 0.0313429754050397 no 3256 0.0294823637961794 4641 627608 SGTC_1374 2889-5571 141 µM -1.88855398919779 0.0313361321615858 no 3257 0.0294758085801237 4652 2853281 SGTC_764 1951-2361 146 µM -1.89023712008978 0.0312184952947004 no 3258 0.0293631271141067 4650 5438930 SGTC_1480 1070-0044 41.2 µM -1.89425643995629 0.0309390552809327 no 3259 0.0290954899372804 4695 3124987 SGTC_744 1594-0068 283 µM -1.89498631612567 0.0308885339744928 no 3260 0.0290471072847842 4653 668392 SGTC_2371 9071574 200 µM -1.89777996537767 0.0306957908014197 no 3261 0.0288625367304692 4672 45596039 SGTC_1251 0490-5699 265 µM -1.90133860645612 0.0304517116303023 no 3262 0.0286288376903558 4660 3883818 SGTC_2684 capsaicin 100 µM -1.91576559111801 0.0294786127513226 no 3263 0.0276974696710801 4679 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3010 9080089 71.4286 µM -1.92158831904059 0.0290932506557113 no 3264 0.0273287897770213 4674 17027233 SGTC_1771 st048882 4.1505 µM -1.92650893418218 0.028770864236736 no 3265 0.0270204286876615 4682 4580403 SGTC_79 0052-0007 94.094 µM -1.92898825091434 0.0286095542792767 no 3266 0.0268661604123287 4641 2801472 SGTC_3342 9147791 14.508 µM -1.93475238006484 0.0282374327304607 no 3267 0.026510344621862 4626 1838168 SGTC_3016 9080866 49.47 µM -1.94226211168891 0.0277586704909843 no 3268 0.0260526886337063 4659 17066299 SGTC_234 nsc-17383 10.7 µM -1.95303185568396 0.0270838964054151 no 3269 0.0254079103062041 4683 408974 SGTC_2885 9057732 51.95 µM -1.96156219498203 0.0265591953962819 no 3270 0.024906738662681 4669 6471414 SGTC_159 3970-0959 50 µM -1.967856141665 0.026177522676933 no 3271 0.0245422961818701 4672 6615653 SGTC_2118 5526350 200 µM -2.00413447608248 0.0240659148285013 no 3272 0.0225278285976677 4677 743594 SGTC_2916 7875993 68.79 µM -2.01202100008057 0.0236263241028813 no 3273 0.0221088616708979 4606 1299250 SGTC_1971 st069429 63.5 µM -2.02044911513708 0.023164029780956 no 3274 0.0216684116136065 4685 1246522 YGL099W LSG1 SGTC_314 1671-0008 2.74 µM -2.02344180460836 0.0230017192781807 no 3275 0.0215138089061407 4573 3913060 SGTC_2884 9058502 51.95 µM -2.02371722348521 0.0229868300044221 no 3276 0.0214996276999672 4681 6471554 SGTC_2718 lomofungin 53.02 µM -2.0274779246646 0.0227843356012172 no 3277 0.0213067799085596 4647 5351222 A RNA synthesis inhibitor. SGTC_285 1486-1325 46 µM -2.02824660725824 0.022743131553641 no 3278 0.0212675426412921 4723 22310230 SGTC_3348 9149464 3.537 µM -2.02866395886174 0.0227207863790337 no 3279 0.0212462646107155 4655 1951442 SGTC_1043 0916-0009 19.3 µM -2.03401706026639 0.0224358160590593 no 3280 0.0209749376907852 4703 3101130 SGTC_2676 harmalol 100 µM -2.03608787985322 0.0223263882672241 no 3281 0.0208707657830271 4698 5459187 A monoamine oxidase inhibitor SGTC_1571 st070080 73.4 µM -2.0512169419541 0.0215405089849771 no 3282 0.0201229123692358 4675 4315245 SGTC_2857 9024691 58.44 µM -2.05797967313794 0.0211968535950119 no 3283 0.0197960423453283 4692 16478292 SGTC_3154 9100113 49.47 µM -2.06156630548294 0.0210164847246797 no 3284 0.0196245223592235 4667 25237525 SGTC_1443 4112-3303 14 µM -2.06250067521758 0.020969709837292 no 3285 0.0195800466691766 4727 704433 SGTC_2308 7584454 197.62 µM -2.06801553588324 0.0206954249806479 no 3286 0.0193192811133359 4671 893577 SGTC_2323 6148992 148.28 µM -2.07897788511059 0.0201592215019938 no 3287 0.0188096915794023 4669 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2154 5570129 200 µM -2.08083926687142 0.0200693555696407 no 3288 0.0187243103331479 4719 673366 SGTC_3263 9137018 49.47 µM -2.09200798957218 0.0195372457275108 no 3289 0.0182189004998752 4664 43844957 SGTC_2078 5212016 200 µM -2.10592986377603 0.0188907880186771 no 3290 0.0176052225627888 4644 1899708 SGTC_523 1934-0222 13.7 µM -2.11478423173696 0.0184891777284677 no 3291 0.0172241707013518 4694 1361595 SGTC_70 0141-0289 43.283 µM -2.15016176233457 0.0169563198708081 no 3292 0.0157712107964558 4693 352408 SGTC_2803 7707263 71.43 µM -2.16122074361736 0.0165000129777843 no 3293 0.0153391458893896 4679 2199229 SGTC_1801 st050089 28.441 µM -2.16532113906161 0.0163335176196732 no 3294 0.0151815503049244 4729 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.18297447782788 0.0156330417141261 no 3295 0.0145188447887914 4726 16623 A steroid. SGTC_1677 st019204 53.9 µM -2.19400154081728 0.0152087012035294 no 3296 0.0141176493911403 4716 3945625 SGTC_337 1315-0038 354 µM -2.20135931918713 0.014931097457433 no 3297 0.0138552982647274 4720 1626437 SGTC_500 h-89 112 µM -2.20887262793896 0.0146521321583476 no 3298 0.0135917507823566 4698 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_190 3970-0790 3.722 µM -2.2177198736001 0.014329398490053 no 3299 0.0132869691685352 4713 2832352 SGTC_340 k038-0059 454 µM -2.22252003473814 0.0141568717281593 no 3300 0.0131240908027408 4731 23733424 SGTC_3186 9110464 49.47 µM -2.22721023656196 0.0139900288370854 no 3301 0.0129666131525398 4732 17018021 SGTC_736 0958-0254 92.6 µM -2.23160593332796 0.0138352037242308 no 3302 0.0128205095769242 4742 6812352 SGTC_2311 7694451 200 µM -2.24588104369297 0.0133425550855525 no 3303 0.0123558141973964 4718 2163142 SGTC_2761 levamisole 97.89 µM -2.25507198861458 0.0130334468522529 no 3304 0.0120644052701671 4724 26879 An alkaline phosphatase inhibitor. SGTC_462 ag-879 158 µM -2.25967339585285 0.012881032188102 no 3305 0.0119207643175514 4730 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_406 estrone 100 µM -2.27293067736963 0.0124504929795375 no 3306 0.0115151788897614 4720 5870 A steroid. SGTC_540 1187-0821 17.3 µM -2.30311996789484 0.0115163190429931 no 3307 0.0106360470610359 4700 847520 SGTC_734 2023-0417 80 µM -2.30315333714936 0.0115153211095859 no 3308 0.010635108608314 4737 3935732 SGTC_2152 5568786 200 µM -2.30669175786877 0.0114099272204281 no 3309 0.0105360050324812 4763 5399883 SGTC_932 2857-0803 154 µM -2.33732687080429 0.0105319503740369 no 3310 0.00971109719139576 4717 674898 SGTC_988 1497-1057 103 µM -2.34272511510757 0.0103834989048381 no 3311 0.00957174072901109 4740 3533044 SGTC_2681 menadione 3.18 µM -2.35876618078176 0.00995308223868029 no 3312 0.00916790234504192 4756 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_816 0325-0417 81.3 µM -2.36121584778523 0.00988874230225033 no 3313 0.00910756258886218 4748 68101 SGTC_1954 st077032 68.9 µM -2.38611915885229 0.00925500292673643 no 3314 0.0085136165016504 4705 698907 SGTC_1728 st035614 33.7865 µM -2.38822381922038 0.00920310948773392 no 3315 0.00846501386105179 4714 15945546 SGTC_185 k048-0037 25.491 µM -2.40544167134881 0.00878805736584971 no 3316 0.00807646516379051 4777 6827589 SGTC_342 k048-0088 23.3 µM -2.43584155941627 0.00809518681598816 no 3317 0.00742859529100317 4765 6820570 SGTC_2142 5622915 118.518 µM -2.4390864573553 0.00802414393837041 no 3318 0.00736222248559942 4769 5322196 SGTC_485 niflumic acid 177 µM -2.47654307738009 0.00724291650739663 no 3319 0.00663308075282343 4779 4488 A COX2 inhibitor. SGTC_2665 lovastatin 100 µM -2.47896277607965 0.00719483760360688 no 3320 0.00658825282900917 4778 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1955 wogonin 32.4 µM -2.48659360213491 0.00704505326024548 no 3321 0.0064486318287578 4731 5281703 A flavanone. SGTC_129 0088-0017 176.636 µM -2.51792508888842 0.00645851046173117 no 3322 0.00590242125469956 4687 182446 SGTC_2664 lyso-paf C-16 73.48 µM -2.55248455265643 0.00586202520094606 no 3323 0.00534788261580364 4766 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_999 SEC7.066 22.7 µM -2.56542905011885 0.00565151256000309 no 3324 0.0051524146873741 4762 740511 YDR170C SEC7 SGTC_3003 9075612 71.4286 µM -2.57774760057299 0.00545744086094112 no 3325 0.0049723303519819 4767 6501993 SGTC_991 3996-0057 64.7 µM -2.59473502339433 0.00519953421582662 no 3326 0.00473319342179956 4761 715343 SGTC_380 3970-0968 6 µM -2.61671037761715 0.00488201614830194 no 3327 0.00443908178679689 4748 2891601 SGTC_409 arachidonic acid 100 µM -2.62290799986146 0.00479564876689731 no 3328 0.00435914055624881 4767 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2507 purpurin 79.67 µM -2.63223802857073 0.00466819772615088 no 3329 0.0042412205737905 4754 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1066 ketoconazole 628 nM -2.67314493845185 0.00414435779952887 no 3330 0.00375718881537463 4781 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3279 9140807 49.47 µM -2.68330883211215 0.00402264708178493 no 3331 0.00364488191627721 4793 45595718 SGTC_1085 doxorubicin 7.67 µM -2.68534736119047 0.0039986249224838 no 3332 0.00362272305082003 4781 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3012 9080433 71.4286 µM -2.69788680393792 0.00385366414140147 no 3333 0.00348905820784312 4774 17688859 SGTC_2320 7373003 200 µM -2.70851055588709 0.00373455415360864 no 3334 0.00337929810518632 4753 5415828 SGTC_1371 2421-0008 32.7 µM -2.71619698841914 0.00365044615676776 no 3335 0.00330183066916402 4765 2827552 SGTC_14 0354-0009 295 µM -2.71723715750672 0.00363919574626984 no 3336 0.00329147095661397 4802 1713507 SGTC_1453 4237-0541 195 µM -2.81228971448273 0.00273343745258677 no 3337 0.00245950877984708 4782 739892 SGTC_1562 morin hydrate 59.1 µM -2.8179109444869 0.00268687250330152 no 3338 0.00241686073495014 4777 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3200 9114385 49.47 µM -2.83953271510928 0.0025143652969254 no 3339 0.00225898310536358 4760 17018030 YLR208W SEC13 SGTC_2162 5663267 200 µM -2.85406190748032 0.00240413815668264 no 3340 0.002158205953889 4784 6456493 SGTC_2436 5633522 8.09 µM -2.88781938389999 0.00216472557967015 no 3341 0.00193961276865955 4775 5724242 SGTC_481 bay k-8644 50 µM -2.92957793606648 0.00189856343209471 no 3342 0.00169711342005126 4790 2303 A calcium channel antagonist. SGTC_329 k048-0121 21.3 µM -2.94885476241347 0.00178603437088234 no 3343 0.00159476915173693 4792 6832902 SGTC_331 k048-0133 24.5 µM -2.95502330800508 0.00175132793152293 no 3344 0.00156322715052186 4796 6813582 SGTC_2495 cafestol 54.53 µM -2.96131594880169 0.00171655667970024 no 3345 0.00153163759383116 4768 16667697 An anti-infammatory. SGTC_1306 1185-0270 9.02 µM -2.99637580777674 0.00153407317974307 no 3346 0.00136604750100489 4803 1548076 SGTC_2528 xanthyletin 44.79 µM -3.05665697979119 0.00126118457324505 no 3347 0.00111910123985933 4792 65188 An natural product with antifungal activity of unknown mechanism. SGTC_286 k060-0067 22.9 µM -3.06660300659493 0.00122068668655144 no 3348 0.00108253098112187 4802 5985051 SGTC_1927 st060202 13.8 µM -3.11431294573837 0.00104247004247498 no 3349 0.000921869105119877 4782 688887 SGTC_2428 5615643 7.78 µM -3.20900308880994 0.000757430330896292 yes 3350 0.00066598030584658 4790 2253075 SGTC_2022 5136654 200 µM -3.56774343534606 0.000209508101014306 yes 3351 0.000180034403484284 4792 1713771 SGTC_2160 5660466 132.927 µM -4.04959777106462 3.08826572938504e-05 yes 3352 2.56528698840002e-05 4806 2859134 SGTC_1450 4112-4260 37.6 µM -4.29296428282545 1.08103291858757e-05 yes 3353 8.81516881927101e-06 4803 1633175 SGTC_3292 9120825 59.784 µM -4.64793229960339 2.11545689231142e-06 yes 3354 1.67639454293609e-06 4810 24824900 SGTC_3288 9119690 36.221 µM -4.87657355515662 6.94452730910318e-07 yes 3355 5.39722240530143e-07 4808 17595618 YKL019W RAM2 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -4.90578638048748 6.0017834479262e-07 yes 3356 4.65268792589463e-07 4808 2374 Ca(2+)-ATPase inhibitor.