SGTCid condition conc unit RLM1|YPL089C.score RLM1|YPL089C.strain.pval RLM1|YPL089C.strain.significant RLM1|YPL089C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_408 cantharidin 100 µM 9.45131804920067 1.34997505825409e-18 yes 1 1.67295290047881e-21 4 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_422 cantharidin 155 µM 8.46244013990563 3.02676117569846e-15 yes 2 1.30920074810397e-17 7 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_354 2783-3500 4.88 µM 8.42021792628174 4.13013046670085e-15 yes 3 1.87892319022989e-17 10 6740761 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 6.66998260165001 4.27942734844009e-10 yes 4 1.27916875994091e-11 25 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2489 cantharidin 73.42 µM 6.29945763539091 3.53458854228141e-09 yes 5 1.49344460601217e-10 7 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_663 1486-0733 13.9 µM 5.81657892962501 4.65365376046888e-08 yes 6 3.00320939806198e-09 21 722445 YPR165W RHO1 SGTC_255 tunicamycin 200.472 nM 5.67097613889601 9.74120668133667e-08 yes 7 7.0993087460253e-09 36 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_360 0957-0399 1.01 µM 5.66338922373283 1.01185323608159e-07 yes 8 7.42059973995895e-09 16 6752301 YPR165W RHO1 SGTC_395 anisomycin 6.25 µM 5.1086691504876 1.42914359852254e-06 yes 9 1.62217940094959e-07 3 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_586 0957-0265 8.15 µM 4.91233775634665 3.43009150302975e-06 yes 10 4.49984231803044e-07 28 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2368 9071271 200 µM 4.77560550426479 6.19259120627051e-06 yes 11 8.95836625868589e-07 13 27209959 SGTC_512 prima-1 270 µM 4.43624142087544 2.50912525906162e-05 yes 12 4.57715893836869e-06 16 322968 A re-activator of the apoptotic function of mutant p53. SGTC_138 0850-0259 40.9225 µM 4.3638462204604 3.34032741231208e-05 yes 13 6.38977139429734e-06 172 6813004 SGTC_2007 4011539 71.82 µM 4.22925381457636 5.62111849299767e-05 yes 14 1.17233849657865e-05 47 45595301 SGTC_2706 st078239 82.5 µM 4.1274181135075 8.2515671619235e-05 yes 15 1.83429501843749e-05 8 15434492 SGTC_1940 st075990 51.1 µM 4.06069771313516 0.000105622097755802 yes 16 2.44631423542916e-05 19 1084979 SGTC_2756 carbadox 75.1 µM 3.96427907226114 0.000149931619838577 yes 17 3.68090448803515e-05 58 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1026 k007-1105 30.6 µM 3.90294578625705 0.000186615799436427 yes 18 4.75144969977538e-05 98 7066794 SGTC_342 k048-0088 23.3 µM 3.86670560091236 0.000212073009763549 yes 19 5.51577323128353e-05 19 6820570 SGTC_2357 9067248 200 µM 3.83255901051246 0.000238994120537686 yes 20 6.34085830053864e-05 21 9150235 SGTC_3098 9119039 49.47 µM 3.73782698449832 0.000331292697156263 yes 21 9.28088018812119e-05 42 17161528 SGTC_404 fumagillin 50 µM 3.57039703098143 0.000579572449300578 yes 22 0.000178220276069351 31 12015870 A methionine aminopeptidase binder. SGTC_2009 4012297 12.05 µM 3.53975870838462 0.000640449242573789 yes 23 0.00020024650940555 81 45595307 SGTC_1017 4239-0030 168 µM 3.53923316635777 0.000641543162240154 yes 24 0.000200645617101532 42 1149593 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 3.53465181338341 0.000651152592730543 yes 25 0.000204156403603506 39 2333 A French combination drug. SGTC_514 4466-0038 2.65 nM 3.47822549989733 0.000780914152311264 yes 26 0.000252372555859323 184 5722064 SGTC_2360 9040895 200 µM 3.44687154661342 0.000862923702469173 yes 27 0.000283559078603097 30 4914414 SGTC_2369 9071472 200 µM 3.43344566437845 0.00090040435115023 yes 28 0.000297980819568454 28 17296037 SGTC_1915 st067105 30.6 µM 3.42620986638053 0.00092121930832686 yes 29 0.000306033633828024 69 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1015 4130-4525 82 µM 3.39375179754191 0.00102014074870406 no 30 0.000344710731803653 42 1363237 SGTC_454 lyso-paf C-16 6.67 µM 3.38676027040455 0.00104268560208109 no 31 0.000353615787201787 40 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2358 9037157 4 µM 3.31869932833175 0.00128728039545343 no 32 0.000452188752736529 56 2388925 SGTC_16 erodoxin 22.806 µM 3.30902004922079 0.00132604077250539 no 33 0.000468115662531886 91 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1786 berberine 21.6 µM 3.28757520077342 0.00141574344205936 no 34 0.000505270978948066 65 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2584 androsterone 48.74 µM 3.2792346912873 0.00145210310727142 no 35 0.000520445160161535 180 2754130 A steroid. SGTC_575 k072-0246 11.9 µM 3.25046582656226 0.00158415481870546 no 36 0.000576080573057354 49 6796779 SGTC_1019 4262-0212 3.4 µM 3.14687071466946 0.00215536918924219 no 37 0.000825139568320453 119 4677213 SGTC_1957 st077035 62.4 µM 3.04787366761998 0.0028695940743597 no 38 0.00115233397045752 44 705593 SGTC_2922 7999257 32.47 µM 3.04066600870948 0.00292912153230715 no 39 0.00118027760463349 34 2988377 SGTC_1460 k062-0059 9.15 µM 3.00080078491848 0.00327892380661358 no 40 0.00134635333415512 53 1373085 SGTC_1134 3477-0009 42.5 µM 2.99187990022754 0.00336216976638582 no 41 0.00138632658886237 97 3973534 SGTC_3097 9117246 49.47 µM 2.97850672908538 0.00349052353711479 no 42 0.00144828334633005 53 16423892 SGTC_2712 st079126 47.7 µM 2.96299743535126 0.00364487824977858 no 43 0.00152329553723233 55 3152970 SGTC_1227 3909-8010 46.6 µM 2.95353180186545 0.00374206715623645 no 44 0.00157080118565149 64 15982272 SGTC_2117 5521686 200 µM 2.92991406099893 0.00399477231586978 no 45 0.00169527879778998 69 803312 SGTC_2272 7805186 180 µM 2.9201107555391 0.00410407880181012 no 46 0.0017495350279553 43 2956062 YPR165W RHO1 SGTC_2912 7964298 10.93 µM 2.8785400792719 0.00459791824178282 no 47 0.0019976025557825 163 2975850 SGTC_2144 5628481 200 µM 2.8590872593187 0.00484671791346409 no 48 0.00212430949424157 75 2818399 SGTC_3041 9091929 49.47 µM 2.84206867358412 0.00507415230872465 no 49 0.00224109177944264 71 25236887 SGTC_2582 agaric acid 100 µM 2.83632934742211 0.00515296739245673 no 50 0.00228176796242431 471 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_649 1123-0311 367 µM 2.83422974902678 0.00518207112158397 no 51 0.00229681466796826 142 693629 YIL048W NEO1 SGTC_2263 7948595 193.29 µM 2.82938304236916 0.00524981333773361 no 52 0.00233189214761923 45 2971371 SGTC_1952 st077036 64.1 µM 2.82278439769176 0.00534330838393534 no 53 0.00238042879366398 93 2937007 SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.80308488874188 0.00563129566571311 no 54 0.00253081723722691 84 5282309 SGTC_2168 5727979 200 µM 2.79675586731377 0.00572670175229627 no 55 0.00258092604171472 70 695210 SGTC_572 0960-0087 17.7 µM 2.79286787737445 0.00578601968208966 no 56 0.00261215127833067 108 6796365 SGTC_927 2425-1185 123 µM 2.77779277010283 0.00602120374557821 no 57 0.00273647553049069 86 730375 SGTC_2314 7727897 200 µM 2.75641649248534 0.00636921150235154 no 58 0.00292192663253839 89 900724 SGTC_3347 9188721 44.724 µM 2.73647301326029 0.00670982467586694 no 59 0.00310508442197039 72 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_612 0302-0167 22.4 µM 2.71827660196232 0.00703454208086626 no 60 0.00328114766981401 118 235821 SGTC_957 1187-1561 14.1 µM 2.70170404717683 0.00734226887408798 no 61 0.00344925683556826 93 1538454 SGTC_1910 st062352 60.4 µM 2.69508714925764 0.00746841131139944 no 62 0.00351851115173386 121 2245730 SGTC_1879 gemcitabine 100 µM 2.67602743851111 0.00784249215530424 no 63 0.00372502727855018 88 60750 A nucleoside analog which inhibits DNA replication. SGTC_1848 st056003 16.4 µM 2.63662983246029 0.00866834454517194 no 64 0.00418670750299233 93 146492 SGTC_396 dithiazanine 1.25 µM 2.6311985576346 0.00878797876484808 no 65 0.0042542154909581 50 10578 An antihelmenthic. SGTC_1032 k061-1018 98.7 µM 2.61777320986887 0.00908992790686776 no 66 0.00442528029071394 123 4005393 SGTC_1951 sophoraflavanone G 9.2 µM 2.60051407586838 0.00949142312006524 no 67 0.00465421001175694 116 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1936 st074407 74.3 µM 2.59690930419994 0.00957721102394922 no 68 0.004703337910115 144 809813 SGTC_917 harmaline 728.087 nM 2.58763540306397 0.00980103719015679 no 69 0.00483186033359928 114 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2704 st078022 71.1 µM 2.5689961718616 0.0102647520754976 no 70 0.00509967920858342 86 54697681 SGTC_595 3909-8003 73.7 µM 2.56442866161157 0.010381261892345 no 71 0.00516729107737368 91 699517 SGTC_567 1080-0542 68.4 µM 2.5608569997901 0.0104731707841851 no 72 0.00522071622421248 79 5950415 SGTC_2979 9012552 45.46 µM 2.55698478732903 0.0105736140460806 no 73 0.00527919174281641 47 17100905 SGTC_1148 3909-7663 27.7 µM 2.55486196201939 0.0106290344199705 no 74 0.0053114958225792 90 4084526 SGTC_2870 9038528 12.99 µM 2.55462590765474 0.0106352126698764 no 75 0.00531509881717027 102 6463316 SGTC_1727 st034309 9.9045 µM 2.53509093503816 0.0111574628941655 no 76 0.00562090696992102 170 870305 SGTC_1288 0973-0013 65.5 µM 2.53191299222765 0.0112444982172897 no 77 0.00567210684020946 100 4315430 SGTC_58 0957-0393 9 µM 2.53038124075929 0.0112866591488312 no 78 0.00569693246166112 569 6997992 SGTC_511 blebbistatin 171 µM 2.52861196486742 0.0113355288037681 no 79 0.00572572773577214 105 3476986 A myosin inhibitor. SGTC_836 0330-0104 1.35 µM 2.52252115309408 0.0115051735751219 no 80 0.00582584710902381 101 46494820 SGTC_2447 5741742 33.78 µM 2.51278964485081 0.0117807977529093 no 81 0.00598903664962857 126 1776504 SGTC_2344 7990960 76.95 µM 2.51079130335298 0.0118381003062219 no 82 0.00602304443642173 108 140813 SGTC_1237 0330-0133 46.1 µM 2.50916460463799 0.0118849243784943 no 83 0.00605085386993669 104 X1237 YHR072W ERG7 SGTC_1160 4092-0570 10.5 µM 2.50347249212576 0.0120500372262949 no 84 0.00614906199872031 141 4994975 SGTC_1144 3486-0183 12.5 µM 2.49495963572915 0.0123006828086408 no 85 0.00629857295216105 126 6744069 SGTC_679 0422-0091 41.4 µM 2.48763322951781 0.0125199995944777 no 86 0.0064298138492239 143 627384 YHR062C RPP1 SGTC_1934 st074720 32.6 µM 2.45984822218895 0.0133827922381865 no 87 0.00694978919045191 176 17250992 SGTC_615 k087-0205 167 µM 2.45799571594359 0.0134421003080768 no 88 0.00698574203808151 87 9642773 SGTC_2352 9027995 87.8 µM 2.44306481848914 0.0139284534231795 no 89 0.00728156070697804 101 2997347 SGTC_1435 4092-0789 56.7 µM 2.43602444964896 0.0141629987360477 no 90 0.00742484038660927 100 2248285 SGTC_881 0833-0569 170 µM 2.43460465490294 0.0142107083930887 no 91 0.00745403402995019 138 5418700 SGTC_706 4262-0057 46.9 µM 2.42297500779869 0.0146067397894578 no 92 0.00769699284734409 148 883298 SGTC_1575 cyproterone acetate 48 µM 2.41192031414376 0.0149919597252856 no 93 0.00793437467151864 137 9880 An androgen receptor antagonist and liver toxin. SGTC_3351 9150312 21.596 µM 2.40671287461906 0.0151764271375451 no 94 0.00804840987801905 137 4904905 SGTC_1454 4239-0054 42.6 µM 2.39879764388533 0.0154605483443312 no 95 0.00822450100578377 157 1340767 SGTC_1522 st012842 45.6 µM 2.3901212740534 0.0157772251651521 no 96 0.00842140509659296 135 3491067 YOR116C RPO31 SGTC_2215 7188065 200 µM 2.37554881875279 0.0163216231031999 no 97 0.00876143713040642 85 940217 SGTC_173 1273-0061 2.693 µM 2.35618168318727 0.0170699784204978 no 98 0.00923194231885268 299 2847414 YPL266W DIM1 SGTC_1419 3993-2473 62.6 µM 2.34472943542126 0.0175261506031828 no 99 0.0095204457057474 135 704026 SGTC_1127 asiatic acid 681.4 nM 2.33512262314666 0.0179168023164512 no 100 0.00976850790111541 158 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2283 7944793 200 µM 2.33097010036561 0.0180879454823203 no 101 0.00987746817146556 180 2970533 SGTC_2241 6772625 37.8075 µM 2.32742993968026 0.0182349491638352 no 102 0.00997119690599264 136 2285411 SGTC_3099 9120367 49.47 µM 2.32141411037701 0.0184870889140916 no 103 0.0101322523570652 124 24824940 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.30597199706769 0.0191479376453331 no 104 0.0105560985475901 153 6708514 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.30551111310607 0.0191679660141066 no 105 0.0105689825413447 111 61125 An anti-inflammatory. SGTC_2885 9057732 51.95 µM 2.30238601952454 0.0193042417320474 no 106 0.0106567063402337 131 6471414 SGTC_1393 3470-5649 58.2 µM 2.29894463639928 0.0194552615570305 no 107 0.0107540416530428 106 4108395 SGTC_2162 5663267 200 µM 2.29491482740898 0.0196333781262453 no 108 0.0108690029496231 116 6456493 SGTC_711 k292-0785 179 µM 2.29423585208248 0.0196635245595172 no 109 0.0108884774968539 146 4146315 SGTC_1461 k072-0203 53.8 µM 2.28749890562674 0.0199647797005857 no 110 0.0110833596201159 139 5418714 SGTC_3070 9117005 49.47 µM 2.28287152269855 0.0201739626906404 no 111 0.0112189686882158 85 8779016 SGTC_3011 9081274 71.4286 µM 2.27444538006622 0.0205596449681999 no 112 0.011469610799425 165 6625322 SGTC_2630 antimycin a 100 µM 2.2629834955088 0.0210942926988381 no 113 0.0118183533562723 187 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1092 toremifene 6.32 µM 2.23678422396191 0.0223606857772701 no 114 0.0126502230638937 182 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1964 st076914 61 µM 2.23214231253373 0.022591620617278 no 115 0.0128027793335159 129 24208661 SGTC_2945 9067681 61.76 µM 2.20872293253711 0.023787615629328 no 116 0.0135969591694487 122 16456930 SGTC_1178 0988-0033 191 µM 2.16808187575939 0.0259893770879862 no 117 0.0150762287844163 222 5392207 SGTC_2399 5884133 200 µM 2.14979725945407 0.0270341972598693 no 118 0.0157856275358912 243 722445 SGTC_1550 gossypolone 36.6 µM 2.14545070843025 0.0272876599920337 no 119 0.0159584142320607 186 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1145 3546-0597 10.2 µM 2.14298632709729 0.0274322451934681 no 120 0.0160570981432209 197 875334 SGTC_1038 k292-0204 154 µM 2.14296967790896 0.0274332241692326 no 121 0.01605776661946 162 4454212 SGTC_401 neomycin 50 µM 2.13143283147258 0.0281186323324888 no 122 0.0165267502573687 148 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_421 streptovitacin 30 mM 2.12972915239749 0.0282210466364092 no 123 0.0165969903709716 208 91467 include heat shock SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.12454699350411 0.0285344752875844 no 124 0.0168122154249353 245 688664 SGTC_2610 ononetin 44.17 µM 2.12063984876572 0.0287726982587358 no 125 0.0169760610085665 250 259632 SGTC_348 k064-0012 10.7 µM 2.11441865078799 0.029155422807849 no 126 0.0172397630385405 153 5066323 SGTC_3185 9108267 49.47 µM 2.10778458039233 0.0295681969337418 no 127 0.0175248136135891 206 4910486 SGTC_1285 0929-0069 65.5 µM 2.10694206793641 0.0296209637894358 no 128 0.0175613007556104 188 1206237 SGTC_2196 6573537 42.6665 µM 2.10667935448595 0.0296374336017661 no 129 0.0175726914835576 143 2903087 SGTC_1465 k213-0056 144 µM 2.10162153138193 0.0299559988491038 no 130 0.0177932211064322 194 24048857 YMR208W ERG12 SGTC_289 k017-0060 526 µM 2.09655905582466 0.0302776956176663 no 131 0.018016313488932 153 5512909 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.0925915552434 0.0305318084245242 no 132 0.0181928155285189 201 390807 SGTC_2310 7668677 200 µM 2.09181661966417 0.0305816476035972 no 133 0.0182274615355519 225 2197143 SGTC_336 4111-0029 111 µM 2.08141733544636 0.0312570103239191 no 134 0.0186978616462165 157 3131175 SGTC_1166 k206-0078 225 µM 2.08131168212625 0.0312639345782041 no 135 0.0187026932841572 216 5404595 SGTC_678 1218-2179 85.9 µM 2.07938082480052 0.0313907017396006 no 136 0.0187911807674318 111 6820081 YOR116C RPO31 SGTC_361 000s-0510 1.45 µM 2.07442994882188 0.0317176860733863 no 137 0.019019699151675 225 660 SGTC_176 1486-1328 72.834 µM 2.0731311275689 0.0318039321641441 no 138 0.0190800389108228 276 22310231 SGTC_2267 7931562 200 µM 2.07021996100709 0.0319979473036835 no 139 0.0192158754179357 179 934880 SGTC_3254 9136651 49.47 µM 2.06362994125607 0.0324407521443616 no 140 0.0195264082501604 207 16454030 SGTC_2231 micatex 6.853 µM 2.04176753192002 0.0339461008288123 no 141 0.0205872981720928 156 20737 An antifungal of unknown mechanism. SGTC_2998 9066762 71.4286 µM 2.02717577640246 0.0349824423211136 no 142 0.0213222197647478 251 4945196 SGTC_1308 1187-1617 41.4 µM 2.02544675539866 0.0351069443559036 no 143 0.0214107552835661 255 2882570 SGTC_2131 toluylene red 5.2905 µM 2.0206192935236 0.0354564823678196 no 144 0.0216595950740329 238 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2113 5491891 107.031 µM 2.01971439936411 0.0355223188145187 no 145 0.0217065103114449 242 789979 SGTC_2204 7233102 200 µM 2.01534889417054 0.0358413448486512 no 146 0.0219340526059463 143 2172480 SGTC_2136 5328288 199.296 µM 2.00739895053415 0.036428346150931 no 147 0.0223536002434198 186 262395 SGTC_1440 4100-1550 40 µM 2.00501462696865 0.0366059236956073 no 148 0.02248074167311 139 742806 SGTC_446 go6976 132 µM 1.99826661276665 0.0371123375504129 no 149 0.0228438815638358 181 3501 A protein kinase C inhibitor. SGTC_1783 st039459 87.517 µM 1.98953183209318 0.0377763382641058 no 150 0.0233212659393319 253 729761 SGTC_1409 3909-8004 61.9 µM 1.98793755729584 0.0378985720345726 no 151 0.0234092981850626 269 2119279 SGTC_961 1252-1571 372 µM 1.98629663960103 0.038024718776582 no 152 0.0235001977804926 240 6813498 SGTC_764 1951-2361 146 µM 1.9777074023745 0.0386906228081139 no 153 0.0239808623546907 233 5438930 SGTC_3019 9081971 49.47 µM 1.97010030188995 0.0392882888751503 no 154 0.0244134381697205 211 16451803 SGTC_1212 0520-0165 585 µM 1.96760749788252 0.0394857672669634 no 155 0.0245566081840237 239 5403258 SGTC_2832 7992762 51.95 µM 1.95527467506816 0.0404746766017832 no 156 0.0252753293336542 226 2985177 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.95188322442055 0.0407501177624923 no 157 0.0254760352007685 212 689007 SGTC_407 eburnamonine 100 µM 1.95120458872824 0.0408054162779386 no 158 0.0255163566738959 203 3195 SGTC_1102 cgs 12066b 26.1 µM 1.94253642188869 0.0415171100192513 no 159 0.0260360975802496 193 6438352 A 5-HT1B full agonist. SGTC_2213 7173844 200 µM 1.94064872007115 0.0416734244363842 no 160 0.0261504501531922 224 892728 SGTC_1332 1480-0653 17.5 µM 1.9397284710913 0.041749799908035 no 161 0.0262063487867149 236 5749438 SGTC_2114 5491910 81.25 µM 1.93891036804894 0.0418177929937625 no 162 0.026256126628232 207 2849228 SGTC_2792 7535235 81.82 µM 1.93864341654125 0.0418399989040676 no 163 0.0262723865058692 234 1281891 SGTC_2301 7769476 200 µM 1.93757566436452 0.041928913557273 no 164 0.0263375069310369 206 977820 SGTC_2249 haloperidol 116.36 µM 1.93008854342302 0.0425566919793281 no 165 0.026797933865998 404 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3220 9131269 49.47 µM 1.92939707489102 0.0426150514541184 no 166 0.0268407932882261 171 17722206 SGTC_77 0828-0286 12.516 µM 1.92612759804117 0.0428918699662809 no 167 0.0270442216942834 282 745345 SGTC_861 0443-0273 110 µM 1.91839649417629 0.0435522258661074 no 168 0.0275303776290134 220 6149169 SGTC_3295 9122362 53.5725 µM 1.91732020130036 0.0436448051883192 no 169 0.0275986325250488 216 4730473 SGTC_2104 5389443 200 µM 1.91478081168096 0.0438638649032753 no 170 0.0277602312792048 269 2244536 SGTC_1378 2093-0007 380 nM 1.90768718509449 0.0444804964384208 no 171 0.0282158295000594 265 3618014 SGTC_721 1187-1332 279 µM 1.89408027239025 0.045682849668711 no 172 0.0291071779084903 160 25730 SGTC_1850 st056238 17 µM 1.8882206871808 0.0462086069981021 no 173 0.0294981648574426 268 5393177 SGTC_3094 9117742 49.47 µM 1.88755078796236 0.0462690226778915 no 174 0.0295431410149645 292 17149698 SGTC_2275 7947463 200 µM 1.88409810626149 0.046581413578279 no 175 0.0297758531753133 221 1225414 SGTC_3212 9128307 49.47 µM 1.882248520869 0.0467494548346817 no 176 0.0299011402555663 258 27243542 SGTC_2119 5528445 120.635 µM 1.87938538034941 0.0470105398376743 no 177 0.0300959455398972 239 791935 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.87864181735485 0.0470785350070506 no 178 0.0301467086017951 253 3256 An antibiotic and ribosome inhibitor. SGTC_72 0744-0168 198.391 µM 1.87862601890248 0.0470799805526272 no 179 0.0301477879320905 257 677577 SGTC_573 3702-0553 84.7 µM 1.87481427556892 0.0474297933658394 no 180 0.0304091392817812 242 1222756 SGTC_3304 9125678 46.087 µM 1.87344103728943 0.0475563278457137 no 181 0.0305037538408166 292 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_731 3966-0296 387 µM 1.86984574480394 0.0478888903733775 no 182 0.0307526209234107 253 660956 SGTC_175 3793-3120 23.7 µM 1.86932001629962 0.0479376756126356 no 183 0.0307891524763007 243 5322297 SGTC_636 0kpi-0074 126 µM 1.86251721889566 0.0485725392005797 no 184 0.0312651103252988 237 616434 SGTC_3280 9140961 49.47 µM 1.86229928148119 0.0485929885662124 no 185 0.0312804583557812 213 4901226 SGTC_2353 9059630 146.67 µM 1.86105264226404 0.048710094758051 no 186 0.0313683715164024 210 4779114 SGTC_2170 morpholine 200 µM 1.86022833948587 0.0487876515315733 no 187 0.0314266135854801 217 121171 Reacts with secondary amines. SGTC_1560 lithocholic acid 53.1 µM 1.85667326902429 0.0491232713495491 no 188 0.0316788263980719 158 9903 A bile acid which acts as a detergent. SGTC_931 2812-0076 566 µM 1.85397504600397 0.0493792285645056 no 189 0.0318713650721048 270 3450959 SGTC_1177 0983-0204 23.6 µM 1.84170259818066 0.0505568721622525 no 190 0.0327593319806547 263 766818 SGTC_197 4544-0043 41.561 µM 1.83643820811428 0.0510688429362179 no 191 0.0331464365318771 337 896523 SGTC_2617 dihydrotanshinone i 20.83 µM 1.83581204215907 0.0511300122348076 no 192 0.0331927299228856 320 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3035 9091303 49.47 µM 1.83027136506884 0.051673817230966 no 193 0.0336046855048282 201 25237002 SGTC_94 0334-0113 514.748 µM 1.8285826413634 0.0518404728293415 no 194 0.0337310775422096 289 6795178 SGTC_1775 st081588 35.1725 µM 1.82717966139811 0.0519792537597694 no 195 0.0338363804156719 289 1426443 YGL099W LSG1 SGTC_1104 tacrolimus 29.8 µM 1.82400444671297 0.0522944318435064 no 196 0.0340756999922503 292 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3146 9095609 49.47 µM 1.82347913343654 0.0523467214752711 no 197 0.0341154273171973 261 17173999 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.82129666249785 0.0525644090746765 no 198 0.0342808867546973 269 66535 A nucleotide analog. SGTC_1742 st038235 28.8875 µM 1.81799041980561 0.0528955537482565 no 199 0.0345327985219673 350 564103 YBR002C RER2 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.81721739267608 0.0529732163126619 no 200 0.0345919164180368 300 5106787 A p450 inhibitor. SGTC_297 0986-0032 24 µM 1.81717919521155 0.0529770561838267 no 201 0.0345948397550805 239 2847425 SGTC_1045 1348-1485 165 µM 1.81549203620331 0.0531468812976968 no 202 0.0347241643570551 336 6810614 SGTC_2091 4-phenylthiadiazole 200 µM 1.8120087586581 0.0534988644095478 no 203 0.0349924215847776 298 270010 SGTC_2785 7756463 72.73 µM 1.8087402727439 0.0538308202338364 no 204 0.0352456815952765 279 2201551 SGTC_391 gliotoxin 8.33 µM 1.80805831122977 0.053900287226004 no 205 0.0352987128120832 317 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1004 4084-0029 199 µM 1.80766487825106 0.0539403959631593 no 206 0.0353293370088651 282 716894 YLR208W SEC13 SGTC_146 3448-8650 53.125 µM 1.80487586594167 0.0542254011802586 no 207 0.0355470545789426 467 2891488 YIL048W NEO1 SGTC_2600 tangeritin 87.95 µM 1.79569553704652 0.0551719494096343 no 208 0.0362714760339326 271 68077 A bioactive flavone. SGTC_166 k072-0058 166.424 µM 1.79423584858624 0.05532364769129 no 209 0.0363877662644327 307 5846229 SGTC_2440 5628896 157.78 µM 1.78842582234256 0.0559307224857497 no 210 0.0368536666560453 268 5522048 SGTC_2035 5154463 94.595 µM 1.7830949470975 0.0564923434272274 no 211 0.0372854244192442 314 2769623 SGTC_1436 4092-1007 8.32 µM 1.78286396050223 0.0565167785286379 no 212 0.0373042254798793 275 2881121 SGTC_1421 4029-0249 71.4 µM 1.78234903814874 0.0565712799783457 no 213 0.0373461652542027 304 2894095 SGTC_2517 totarol 10 µM 1.77600883868262 0.057245751481955 no 214 0.0378657301668054 276 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2571 chrysanthemic acid 100 µM 1.77286132902877 0.057582926610134 no 215 0.0381258439735166 268 2743 An insecticide. SGTC_950 1165-0508 94.1 µM 1.769569694424 0.0579372098925427 no 216 0.0383994255368174 307 6148369 SGTC_1290 0986-0249 10.2 µM 1.7660972211803 0.058312811825489 no 217 0.0386897698009735 246 53329 SGTC_2240 6690706 185.951 µM 1.75550044752225 0.0594708495122368 no 218 0.0395868720885364 256 805876 SGTC_2155 5570423 76 µM 1.75027852137099 0.0600481045745013 no 219 0.0400351326423306 294 797402 SGTC_1892 st058411 7.36 µM 1.74304750051029 0.0608546871544776 no 220 0.0406626589539541 355 3934738 SGTC_1239 0337-0584 35.4 µM 1.73686297374803 0.0615512383981321 no 221 0.041205680148996 392 914301 YML130C ERO1 SGTC_951 1171-0579 82.7 µM 1.73429829253306 0.0618419134676752 no 222 0.0414325851468972 420 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1663 st014140 55.4 µM 1.73346232453847 0.0619368913504542 no 223 0.0415067641691639 332 4207120 SGTC_1705 st027868 56.3335 µM 1.72846232508871 0.0625073411252628 no 224 0.0419526849623985 271 292948 SGTC_2072 5231554 129 µM 1.72429759369125 0.0629856150083925 no 225 0.0423270667420872 278 789545 SGTC_2060 5238662 140 µM 1.72322409835939 0.0631093551300164 no 226 0.0424240037246517 302 790130 SGTC_962 1254-0300 21.5 µM 1.72239897540738 0.0632045943776524 no 227 0.0424986345876516 297 7340576 SGTC_2596 sinensetin 100 µM 1.72041622171675 0.0634339099247466 no 228 0.0426784051957182 313 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2513 baicalein 25.65 µM 1.71778262647064 0.0637394992938128 no 229 0.0429181358027722 310 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_810 3825-7150 143 µM 1.71772472573862 0.0637462306517252 no 230 0.0429234185836926 309 22330411 YGL099W LSG1 SGTC_371 0195-0006 7.36 µM 1.71438675891897 0.0641352279280052 no 231 0.0432288593528849 269 3928593 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.71262987664526 0.0643407099620831 no 232 0.0433903266164994 366 676296 Flavone; oxidizing agent. SGTC_2687 chenodiol 100 µM 1.71162007496488 0.0644590460085491 no 233 0.0434833531553997 289 5702181 A cholesterol synthesis inhibitor. SGTC_2726 cimetidine 79.27 µM 1.71053199126163 0.0645867449159706 no 234 0.0435837714415798 231 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_17 0960-0276 49.807 µM 1.70909640899653 0.0647555272625134 no 235 0.0437165463316049 364 6821114 SGTC_541 4513-1321 94 µM 1.70410772051984 0.0653447147143112 no 236 0.0441804822659322 319 747515 SGTC_2947 9072639 7.68 µM 1.69339885986809 0.066623518328939 no 237 0.045189785882095 386 16488146 SGTC_1484 3473-2379 286 µM 1.68921512523689 0.0671283508651408 no 238 0.0455891057346564 376 671917 SGTC_1179 1021-1431 9.29 µM 1.68791919289973 0.0672853237950853 no 239 0.0457133709031013 414 2840958 SGTC_271 rotenone 740 µM 1.6833197901954 0.0678447290255049 no 240 0.0461566006633769 363 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2234 tolnaftate 200 µM 1.68150269814777 0.068066721259261 no 241 0.0463326564030536 230 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_609 0986-0026 86.3 µM 1.67904318518097 0.0683680900623284 no 242 0.0465718138180966 370 2848610 SGTC_2864 9034755 47.6 µM 1.67692591042336 0.0686283475044085 no 243 0.0467784853609645 320 4930451 SGTC_1746 st038117 42 µM 1.67379325639107 0.0690148170976927 no 244 0.0470856190729294 357 2898218 SGTC_1078 idebenone 36.1 µM 1.66911661928034 0.0695948833199826 no 245 0.0475471351368305 408 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2206 7254556 146.969 µM 1.6689678597217 0.0696133961106951 no 246 0.0475618747961214 237 4398905 SGTC_2337 9009472 200 µM 1.66321186506977 0.0703326321257686 no 247 0.0481350167032122 399 5742383 SGTC_2713 st079149 53.4 µM 1.66321112450176 0.0703327250291322 no 248 0.0481350907978154 354 3103253 SGTC_1881 5652484 16 µM 1.66079163349706 0.0706367513191416 no 249 0.0483776510332623 360 2255129 SGTC_390 dec-rvkr-cmk 16.7 µM 1.66037212784834 0.0706895677847745 no 250 0.0484198068375144 362 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3007 9078383 71.4286 µM 1.65349532855161 0.0715597007683513 no 251 0.0491150480268598 345 6496995 SGTC_398 bronopol 33.3 µM 1.64037556166738 0.073242532251181 no 252 0.0504635516942 363 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3279 9140807 49.47 µM 1.63833063911466 0.0735075332831277 no 253 0.0506763697628996 316 45595718 SGTC_2389 9091542 195.52 µM 1.63720057385621 0.0736542923816984 no 254 0.0507942835955918 387 3626624 YOL127W RPL25 SGTC_860 0443-0016 25.1 µM 1.633026274369 0.0741983419158005 no 255 0.0512317354106556 346 5337942 SGTC_1673 st016611 27.3 µM 1.63269799969211 0.0742412568194354 no 256 0.0512662641769584 385 5226799 SGTC_2869 9037858 32.47 µM 1.63020405740402 0.0745679057918778 no 257 0.0515291883443829 292 27187042 SGTC_1129 3453-1384 223 µM 1.6279462714504 0.074864568779389 no 258 0.0517681394179683 401 1084452 SGTC_1930 st074634 34.3 µM 1.62703933914228 0.0749839887972057 no 259 0.0518643715122349 379 684253 YOR116C RPO31 SGTC_3243 9134147 49.47 µM 1.62397905637436 0.0753880229597748 no 260 0.0521901392381228 304 24282180 SGTC_268 camptothecin 39.6153 µM 1.62367230449398 0.0754286132329843 no 261 0.0522228824531726 481 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2781 5567276 71.43 µM 1.62349412810194 0.0754521976811487 no 262 0.0522419087918417 369 2853274 SGTC_2293 7624732 200 µM 1.62345504729158 0.0754573713925666 no 263 0.052246082722357 340 894453 SGTC_374 0880-0231 82.3 µM 1.61895946822075 0.0760543245790271 no 264 0.0527279921157355 361 6833587 SGTC_2661 dactinomycin 12.96 µM 1.61486808301854 0.076600724984332 no 265 0.0531696326966184 387 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1771 st048882 4.1505 µM 1.61178291400284 0.0770147169319623 no 266 0.0535045937416316 346 4580403 SGTC_892 0929-0076 29 µM 1.6113290843887 0.0770757585172369 no 267 0.0535540074033802 427 5751038 SGTC_100 0086-0128 49.5915 µM 1.61035360089697 0.0772070887166121 no 268 0.0536603419103601 425 93297 SGTC_2567 aureobasidin a 60 nM 1.60819892492751 0.0774977770739921 no 269 0.0538958092828507 424 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1114 scopoletin 1.73284 µM 1.60372449721413 0.0781040781980595 no 270 0.0543873968135347 328 5280460 A coumarin with genotoxic properties. SGTC_439 amiodarone 34.4 µM 1.60115140538423 0.0784543672907226 no 271 0.0546716944505062 436 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_273 hydroxyurea 18.1 mM 1.59869743781744 0.0787895477106375 no 272 0.054943923604481 431 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_641 4092-0595 30 µM 1.59766138767642 0.0789313841421369 no 273 0.055059178209627 372 786260 SGTC_449 xestospongin c 11.1929 µM 1.59675720081351 0.0790553263249926 no 274 0.0551599198074058 392 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3030 9087619 49.47 µM 1.5939138224292 0.0794460454142054 no 275 0.0554776690371846 351 25236973 SGTC_1245 0418-0076 17.2 µM 1.59084068524421 0.0798699780077927 no 276 0.0558227170638251 388 6790114 SGTC_1559 coumarin 343 70.1 µM 1.58848392666662 0.0801962451129708 no 277 0.0560884764049256 311 108770 A hepatotoxic, DNA x-linker. SGTC_1330 1469-0054 61.8 µM 1.57974376635414 0.081415022016568 no 278 0.0570827791598068 367 7102664 SGTC_73 0327-0325 16.231 µM 1.57806490212477 0.0816507234053187 no 279 0.0572753501726546 449 53298 SGTC_1071 trifluoperazine 6.31 µM 1.57798430051083 0.0816620522654584 no 280 0.057284608277056 403 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_867 0518-0118 155 µM 1.5770582115558 0.0817923025937406 no 281 0.0573910657038853 375 6848158 SGTC_62 0180-0423 3.232 µM 1.57562886850936 0.0819936406521583 no 282 0.0575556795368684 369 30102 YGL099W LSG1 SGTC_2800 7887935 81.82 µM 1.57504730666939 0.0820756665731455 no 283 0.0576227627445444 371 2961002 SGTC_2991 9074669 71.4286 µM 1.57292065492709 0.0823761448612644 no 284 0.0578685958885065 457 17333109 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.57038682194573 0.0827352349889974 no 285 0.0581625731936405 404 688801 SGTC_3043 9092303 49.47 µM 1.56683371612367 0.0832407568450014 no 286 0.058576782131133 365 25236084 SGTC_1301 naphtanilide LB 4.81 µM 1.5662008773491 0.0833310377773138 no 287 0.0586507986991114 395 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2222 6885208 172.143 µM 1.56309821417915 0.0837747297940827 no 288 0.0590147478111842 309 609514 SGTC_1564 D-Arginine 115 µM 1.56003840626917 0.0842140289771086 no 289 0.0593754027498565 402 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_165 k038-0023 64.381 µM 1.55799030644739 0.0845090409309097 no 290 0.0596177730109068 471 46368543 SGTC_1190 1486-1332 13 µM 1.55773328854059 0.0845461169324647 no 291 0.0596482429483342 382 4150046 SGTC_1353 1498-1206 8.11 µM 1.55697915014065 0.0846549752518579 no 292 0.0597377178546018 465 6756808 SGTC_372 0155-0182 15.9 µM 1.55620654409462 0.0847666083179614 no 293 0.0598294928732068 418 771486 SGTC_14 0354-0009 295 µM 1.55528076098351 0.0849005191225584 no 294 0.0599396086520555 392 1713507 SGTC_2728 chlorpromazine 9.18 µM 1.55384684081438 0.0851082428711567 no 295 0.060110477216535 266 2726 A thorazine and dopamine antagonist. SGTC_2256 7954252 200 µM 1.55074537010886 0.0855588375123176 no 296 0.0604813585410267 293 2972920 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.5507367179356 0.0855600970301382 no 297 0.0604823956874384 374 5355888 SGTC_2377 9073351 62.6 µM 1.54796938140025 0.0859636576993913 no 298 0.0608148342518845 381 7337946 YHR072W ERG7 SGTC_2845 9003024 42.97 µM 1.54649962819975 0.0861785701019034 no 299 0.0609919749038174 424 2990173 SGTC_1287 0971-0001 34.6 µM 1.54644290101907 0.0861868729947808 no 300 0.0609988199708648 456 4665869 SGTC_136 0097-0015 404.482 µM 1.54066178901485 0.0870361685878411 no 301 0.0616995605896756 435 4861337 SGTC_155 k072-0202 43.6 µM 1.53912314152388 0.0872632590359382 no 302 0.0618871182381467 361 5857737 SGTC_1986 st071812 45 µM 1.53853482688958 0.0873502057652874 no 303 0.061958949951044 345 11838594 SGTC_1377 2944-0135 198 µM 1.53721203825576 0.0875459361915362 no 304 0.062120696663376 433 1894137 SGTC_44 0929-0055 61.211 µM 1.53198189073378 0.0883230367290092 no 305 0.062763451809794 371 1379590 SGTC_1151 3909-8316 15.3 µM 1.52858732207376 0.0888301489467673 no 306 0.0631833904488425 416 800431 SGTC_1072 oxiconazole 14.9 nM 1.52829752607547 0.0888735416003391 no 307 0.0632193419403213 440 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_92 0063-0024 660.874 µM 1.52440733884299 0.0894575681547884 no 308 0.0637034939845954 441 3594437 SGTC_823 0417-1665 178 µM 1.52335884698769 0.0896154635611114 no 309 0.0638344759662717 407 3429856 SGTC_1802 st050112 57.9 µM 1.52231897481459 0.0897722654888442 no 310 0.0639645879412961 400 4662563 SGTC_3242 9133940 49.47 µM 1.52100209291745 0.0899711301712901 no 311 0.0641296560541232 391 17248444 SGTC_1037 k284-1091 78.7 µM 1.51561996566963 0.0907872984499121 no 312 0.0648077377835847 348 3334711 SGTC_1329 1447-1697 50.6 µM 1.51384517372186 0.091057636282502 no 313 0.0650325561330337 431 2840515 SGTC_1050 3232-1156 69.3 µM 1.50820804751757 0.0919202478094577 no 314 0.065750644139487 432 700529 SGTC_1250 0485-0349 40.2 µM 1.5072961538481 0.0920603555780612 no 315 0.0658673815088237 429 6842794 YDL195W SEC31 SGTC_1425 4048-4433 7.33 µM 1.5057778376273 0.0922939877627213 no 316 0.0660621072239595 475 23734946 SGTC_3005 9076496 71.4286 µM 1.50130762702036 0.0929843927460212 no 317 0.0666380065962834 377 21368410 SGTC_2390 9097792 176.6 µM 1.49978611227988 0.0932202529410973 no 318 0.066834907936249 398 4497149 SGTC_2407 paclitaxel 400 µM 1.49956031649827 0.093255292695226 no 319 0.0668641668000589 456 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_19 0279-0214 38.434 µM 1.49914127005064 0.093320347529768 no 320 0.066918493555679 513 3566274 YBR002C RER2 SGTC_1428 4049-0204 61.7 µM 1.4986353494987 0.0933989337955235 no 321 0.0669841284869084 427 X1428 SGTC_624 k048-0052 28 µM 1.49797176508249 0.0935020845931515 no 322 0.0670702932048339 393 6835531 SGTC_2179 6298986 200 µM 1.4972724935472 0.0936108737911809 no 323 0.0671611845333085 384 738374 SGTC_1849 st056239 19.2 µM 1.49492848922817 0.0939762241075801 no 324 0.0674665530819716 450 5393181 SGTC_2229 7354935 190 µM 1.49192062758366 0.0944465872115415 no 325 0.0678599771812038 337 318112 SGTC_1070 indatraline 8.81 µM 1.49165926224127 0.0944875408025461 no 326 0.0678942468975301 447 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2070 5230947 200 µM 1.48932684078322 0.0948535901072979 no 327 0.068200661542824 423 2835538 SGTC_2148 5546263 113.568 µM 1.48787146932099 0.0950825243135271 no 328 0.0683923965599065 422 792097 SGTC_2689 tacrolimus 100 µM 1.48664936619209 0.0952750788634762 no 329 0.0685537211296503 439 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1503 4585-0012 61.3 µM 1.48623596552586 0.0953402792097381 no 330 0.0686083587593937 395 2922052 SGTC_3078 9116413 49.47 µM 1.48616277720754 0.0953518256793654 no 331 0.0686180352858887 388 17177322 SGTC_1150 3909-7983 10.9 µM 1.48569569897917 0.0954255379807489 no 332 0.0686798144022053 461 23965914 SGTC_3349 9149703 23.001 µM 1.4852966495967 0.095488547477788 no 333 0.0687326295060631 399 4910494 SGTC_2101 5377231 179.231 µM 1.48224012568953 0.0959721853476853 no 334 0.0691382066873846 396 2844213 SGTC_2452 5863136 48.41 µM 1.48079327849344 0.0962017490831866 no 335 0.0693308341007309 433 2184096 SGTC_849 0386-0493 241 µM 1.48042614300534 0.0962600647213806 no 336 0.0693797787411973 406 726119 SGTC_1437 4092-1038 11.6 µM 1.47713536121126 0.0967839316285279 no 337 0.0698196781959203 443 3977136 SGTC_1003 4049-0218 100 µM 1.47544806938021 0.0970533459350524 no 338 0.0700460600171398 463 295161 SGTC_126 0417-1624 672.48 µM 1.46808314758644 0.0982357688752406 no 339 0.0710408193280429 548 41912 YDL195W SEC31 SGTC_1445 4239-0156 97.7 µM 1.46769891689968 0.0982977446653338 no 340 0.071093012545445 502 4008346 SGTC_145 3737-0113 38.366 µM 1.46120791791499 0.0993490640915667 no 341 0.0719791953854097 557 6849351 SGTC_1163 k060-0048 49.9 µM 1.46028577355441 0.0994990842432399 no 342 0.0721057751447256 483 6809982 SGTC_1943 st076331 65.2 µM 1.45929362446813 0.099660678023678 no 343 0.0722421547094011 444 24208415 SGTC_2061 5245884 80.95 µM 1.45709778002284 0.100019002326039 no 344 0.0725446955578957 461 573863 SGTC_1604 st002052 72.4 µM 1.45542067105164 0.100293310843202 no 345 0.0727764185993526 449 6254834 YHR062C RPP1 SGTC_1992 st073643 23.3 µM 1.44957642635111 0.10125348758747 no 346 0.0735883368619067 426 3161292 SGTC_3298 9116858 71.43 µM 1.44762633923754 0.101575361611872 no 347 0.0738607903686027 447 2506942 SGTC_2561 acetosyringone 100 µM 1.44744772853134 0.101604879628036 no 348 0.0738857831827085 511 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1906 st060206 94.7 µM 1.44709366175933 0.101663412773553 no 349 0.0739353464884757 480 5133468 SGTC_1600 coumarin 106 71.1 µM 1.44316803286484 0.102314030527312 no 350 0.0744865711322498 466 100336 A hepatotoxic, DNA x-linker. SGTC_2161 5662504 8.5105 µM 1.44060180278843 0.102740980718111 no 351 0.0748486054143785 436 2859334 SGTC_468 gf-109203x 121 µM 1.43613607962181 0.103487038786931 no 352 0.0754818116609795 305 2396 A protein kinase C inhibitor. SGTC_3246 9135460 32.98 µM 1.43502646061187 0.103673023677218 no 353 0.0756397787526502 375 41446951 SGTC_989 1501-0895 10.3 µM 1.42681061111185 0.10505764385662 no 354 0.0768172458919781 429 2830112 SGTC_1789 tunicamycin 25 nM 1.42064735251352 0.106105091851377 no 355 0.0777096525250175 450 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.41904578556939 0.106378509570394 no 356 0.077942834044686 495 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2021 4019055 173 µM 1.41840684058002 0.106487731399658 no 357 0.0780360098110544 653 44827708 YER133W GLC7 SGTC_353 1988-1175 58.3 µM 1.4175236844985 0.106638832152134 no 358 0.0781649373721193 433 2788357 SGTC_274 sirtinol 40.1 µM 1.41626368725092 0.106854675131598 no 359 0.0783491577027626 471 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1159 4092-0538 61.2 µM 1.41588808107991 0.106919079039635 no 360 0.078404137576972 519 717301 SGTC_750 4073-0104 132 µM 1.41558276392668 0.106971451359702 no 361 0.078448850347745 373 22330957 SGTC_785 1270-0111 65.3 µM 1.41548748248159 0.106987799169954 no 362 0.078462807983386 478 6741994 SGTC_1616 st002734 56.1 µM 1.41191659661808 0.107601769948298 no 363 0.0789872601649127 494 4026101 SGTC_1969 st069479 40.1 µM 1.41000120172884 0.107932143230925 no 364 0.0792696640320943 405 3895485 SGTC_392 N-ethylmaleimide 8.33 µM 1.40986634620636 0.107955431027262 no 365 0.0792895757589141 449 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_642 0335-0876 158 µM 1.40644845217057 0.108546865346628 no 366 0.0797955006269687 484 6812350 SGTC_3204 9114183 49.47 µM 1.40568223193928 0.108679771760289 no 367 0.0799092526968317 467 17027248 SGTC_2033 5192550 145 µM 1.40463120319792 0.108862270576243 no 368 0.0800654864851328 445 182073 SGTC_201 4262-0159 12.803 µM 1.39903590854313 0.109837537005253 no 369 0.0809011076429843 407 1341029 SGTC_1486 3970-0793 4.53 µM 1.39593411250804 0.110380877718852 no 370 0.0813671685187868 473 2844330 SGTC_331 k048-0133 24.5 µM 1.39592586307581 0.110382325334515 no 371 0.0813684107331687 430 6813582 SGTC_1266 0828-0227 32.9 µM 1.39479727250596 0.110580499473473 no 372 0.0815384908181934 456 3913820 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.39261927445949 0.110963664339545 no 373 0.0818674756625221 475 6312947 SGTC_991 3996-0057 64.7 µM 1.39166754711252 0.111131395455936 no 374 0.0820115469829384 478 715343 SGTC_977 1348-1378 135 µM 1.39080739219901 0.11128314409609 no 375 0.0821419204495867 499 X977 SGTC_3115 9123671 49.47 µM 1.38564544125987 0.112196932865815 no 376 0.0829275976959977 456 3286988 SGTC_1947 st076332 61.6 µM 1.38103364083622 0.113017856987101 no 377 0.0836343086449952 407 24208416 SGTC_3159 9100096 49.47 µM 1.3802361776944 0.113160243131245 no 378 0.0837569691884655 480 25236875 SGTC_2385 9074692 200 µM 1.37955656507647 0.113281688177746 no 379 0.0838616093511739 499 17046906 SGTC_2666 tannic acid 100 µM 1.37941673564605 0.113306686869875 no 380 0.0838831511048655 526 16134267 A thiamine antagonist. SGTC_544 k015-0020 52.4 µM 1.37058225678822 0.114894100191958 no 381 0.085252608601721 476 3008304 SGTC_1284 0929-0043 16 µM 1.3694158377663 0.115104863273012 no 382 0.0854346631742316 514 1239883 SGTC_2852 9023854 51.95 µM 1.36933611032656 0.11511927944835 no 383 0.085447117649308 523 19798528 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.36615829834769 0.115694931503088 no 384 0.0859446416548025 518 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3332 9141069 11.198 µM 1.36615032020276 0.115696379290886 no 385 0.0859458934498857 435 17332883 SGTC_1965 Pectolinarigenin 58.4 µM 1.36168754112518 0.11650825427207 no 386 0.0866482574009638 490 5320438 An anti-inflammatory. SGTC_2695 st077686 51.995 µM 1.35875181240916 0.117044524649071 no 387 0.0871126238372198 471 2876092 SGTC_1471 k673-0312 37 µM 1.35467961499136 0.117791286311892 no 388 0.0877598276925045 494 24099884 SGTC_905 2-aminofluorene 215 µM 1.3514796887998 0.118380451407831 no 389 0.0882709109832245 546 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1511 0906-3109 28.5 µM 1.34952964697236 0.11874050978501 no 390 0.0885834521735831 617 2882180 SGTC_528 3492-0019 172 µM 1.34874069547007 0.118886402461295 no 391 0.0887101346138337 750 2869262 SGTC_2043 5101342 149 µM 1.34864791457041 0.118903567793449 no 392 0.0887250413633632 519 678451 SGTC_1218 1348-1416 30.7 µM 1.34794289529951 0.119034060121579 no 393 0.0888383750414976 522 6787668 SGTC_2677 mitomycin C 100 µM 1.34740178738422 0.119134282587663 no 394 0.0889254326302743 444 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1317 1273-0028 910 nM 1.34626258426815 0.119345477231651 no 395 0.0891089239419193 508 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_820 1582-0060 59.9 µM 1.34473090587548 0.119629848315191 no 396 0.0893560751189888 524 3848840 SGTC_1093 fluphenazine 7.97 µM 1.33847074686316 0.120797075304375 no 397 0.0903715150725822 547 6602611 An atypical antipsychotic. SGTC_88 0180-0332 8.668 µM 1.33821898816768 0.120844183613211 no 398 0.0904125305317219 518 3101745 SGTC_1028 k015-0029 4.8 µM 1.32880943868638 0.12261414878909 no 399 0.0919554237006733 556 4588309 SGTC_1307 1187-1599 12.2 µM 1.32853233930032 0.122666546278826 no 400 0.092001153700774 522 1538471 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.32680059741996 0.122994361958399 no 401 0.0922873264036258 511 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_878 0828-0289 13.7 µM 1.32651792635528 0.123047929344683 no 402 0.0923341006601249 584 745350 YLR208W SEC13 SGTC_1529 apigenin 74 µM 1.32572453403265 0.123198367975612 no 403 0.0924654789091203 565 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1065 prochlorperazine maleate 2.48 µM 1.32293859784396 0.123727642440541 no 404 0.0929278990677782 552 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_187 1488-2104 32.728 µM 1.32197210349978 0.123911629241249 no 405 0.0930887202157694 551 2852859 SGTC_3083 9117465 49.47 µM 1.32047915992008 0.124196209809458 no 406 0.0933375447479557 531 16420915 SGTC_1197 1601-0112 267 µM 1.31483962889519 0.125275325016169 no 407 0.0942819028994943 577 7350313 SGTC_91 0417-1751 58.384 µM 1.31385331632852 0.125464724876309 no 408 0.0944477856937613 664 6795624 SGTC_3348 9149464 3.537 µM 1.31352882723846 0.125527079611281 no 409 0.0945024068491346 538 1951442 SGTC_2775 cyproheptadine 69.59 µM 1.3133429814434 0.125562801999747 no 410 0.0945337007056701 543 2913 A selective serotonin reuptake inhibitor. SGTC_2432 5630864 12.22 µM 1.3125275482933 0.125719624498478 no 411 0.0946710986511117 533 5714970 SGTC_2516 gossypol 71.55 µM 1.30939955309665 0.126322461521481 no 412 0.0951995213926473 576 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3311 9131146 2.8755 µM 1.30423920228951 0.127321377558731 no 413 0.0960760187165503 559 4900406 YPR165W RHO1 SGTC_2867 9039098 71.43 µM 1.30087028708714 0.127976472952963 no 414 0.0966514290662405 559 6463460 SGTC_1660 st012960 28.1 µM 1.29916703470037 0.128308565095654 no 415 0.0969433059731846 542 24207266 SGTC_2937 9044753 11.33 µM 1.29743696462558 0.12864649810034 no 416 0.0972404404153091 579 6465530 YGL099W LSG1 SGTC_2974 9094440 9.66 µM 1.29660093235781 0.128810020658814 no 417 0.0973842657515281 592 25236134 SGTC_431 k089-0097 107 µM 1.29549242576422 0.129027059704957 no 418 0.0975752062745361 621 5499420 SGTC_660 4031-1742 102 µM 1.29449633497508 0.12922230460304 no 419 0.0977470172133599 586 6738706 SGTC_2462 5162487 171.77 µM 1.28823271850447 0.130454735840644 no 420 0.0988324829192894 557 2259986 SGTC_2294 7971431 200 µM 1.28790952124047 0.130518548055386 no 421 0.0988887303703733 482 5741572 SGTC_139 0099-0334 718.624 µM 1.28333691139918 0.131423679648817 no 422 0.0996870331195974 639 97690 SGTC_879 0831-1030 162 µM 1.27621956690884 0.132841137583194 no 423 0.100938956825903 632 1549252 SGTC_886 0866-0150 153 µM 1.27443277261435 0.133198634446129 no 424 0.101255041940346 586 271463 SGTC_3121 9125696 49.47 µM 1.27425128310162 0.133234983369583 no 425 0.101287187860316 518 1235365 SGTC_1167 k781-0610 148 µM 1.27308450094628 0.133468830799731 no 426 0.101494029090848 615 4525169 SGTC_2956 9076196 2.52 µM 1.26764911940887 0.134561914021243 no 427 0.10246164120976 588 16423868 SGTC_755 1995-0008 37.3 µM 1.26743140947353 0.134605824235523 no 428 0.102500537384574 592 689533 SGTC_3049 9092223 49.47 µM 1.26543112831085 0.135009723964317 no 429 0.102858411223499 544 8623917 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.26387243272878 0.135325033740226 no 430 0.103137908919592 569 97141 SGTC_503 tyrphostin 8 294 µM 1.26264878881042 0.135572919050656 no 431 0.103357712937796 564 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2261 9010538 184.68 µM 1.26212278266779 0.13567957272173 no 432 0.103452304230479 491 6457250 SGTC_748 act1.228 77.9 µM 1.26094366156246 0.135918861586015 no 433 0.103664572963336 626 4421505 YNR035C ARC35 SGTC_1305 1181-0477 144 µM 1.25850608608442 0.136414454753564 no 434 0.10410439377642 555 6252086 SGTC_2053 5265679 138 µM 1.25820048323054 0.136476675178512 no 435 0.104159630133013 600 764595 SGTC_2897 9048598 12.99 µM 1.25759610813218 0.136599782470303 no 436 0.104268930794094 548 6467404 SGTC_316 k060-0003 58.6 µM 1.25597434482853 0.136930500343106 no 437 0.104562635914703 566 6152314 SGTC_3191 9110352 49.47 µM 1.25589988108041 0.136945698481484 no 438 0.1045761358495 539 17122424 SGTC_2238 6671620 73.2395 µM 1.25448608978431 0.137234473676177 no 439 0.104832689302515 555 729941 SGTC_2908 7930301 100 µM 1.25439213778955 0.137253678651404 no 440 0.104849754423631 633 2223178 SGTC_1399 3562-5772 25 µM 1.25143154953316 0.137859800723449 no 441 0.105388536346763 498 23847490 SGTC_1116 jasmonic acid  1.58368 µM 1.25122641787149 0.137901864929035 no 442 0.105425941234352 579 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2679 rapamycin 1 nM 1.25098279006804 0.137951834509441 no 443 0.105470378203797 681 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_312 4092-0653 6.84 µM 1.24794759786573 0.138575406804901 no 444 0.106025124051515 679 1148278 SGTC_3066 9117245 49.47 µM 1.24621927357978 0.13893134334311 no 445 0.106341952541153 594 17176980 SGTC_1676 st018489 23.4 µM 1.24393322050407 0.139403095749093 no 446 0.106762070790593 590 3696235 SGTC_1724 st037281 8.293 µM 1.24378141793724 0.139434460429563 no 447 0.106790010577476 605 574124 YDL195W SEC31 SGTC_2730 imipramine 71.33 µM 1.2374597187988 0.140744881376251 no 448 0.107958229955314 686 3696 A tricyclic antidepressant. SGTC_1199 1638-0010 4.46 µM 1.23737397007119 0.140762713431788 no 449 0.107974138915609 625 3111136 SGTC_1611 st001856 99.4 µM 1.23711188671723 0.140817225025406 no 450 0.108022773701523 566 647478 SGTC_3088 9117578 49.47 µM 1.23626778823904 0.140992889232651 no 451 0.10817952018943 569 678341 SGTC_2560 caryophyllene 100 µM 1.23495886493762 0.141265581335941 no 452 0.108422906887583 631 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3239 9133757 49.47 µM 1.23396017473292 0.141473881917174 no 453 0.108608872348162 579 17036923 SGTC_1942 st076330 65.2 µM 1.23338459086584 0.141594028113807 no 454 0.10871615561034 583 24208414 SGTC_1629 st005085 44.9 µM 1.23297296828455 0.141679991750106 no 455 0.108792924800045 602 24207091 SGTC_2940 9060638 45.86 µM 1.2327816458884 0.141719959726454 no 456 0.108828620426873 598 4027022 SGTC_704 1310-0270 142 µM 1.2312872270874 0.142032412285522 no 457 0.109107728687368 619 5718033 SGTC_2778 tioconazole 65.09 nM 1.22952501207456 0.142401454314529 no 458 0.1094375129696 616 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2652 actinonin 100 µM 1.22932988402539 0.142442357767972 no 459 0.109474073583869 565 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_657 3534-0529 86.7 µM 1.22748482094945 0.142829519463323 no 460 0.109820211733084 579 1049549 SGTC_2095 5432005 200 µM 1.22437725736854 0.143483206437584 no 461 0.11040497231186 553 783734 SGTC_232 clozapine 119 µM 1.22271027786786 0.143834692470238 no 462 0.110719571822225 592 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1 0258-0098 57.368 µM 1.22244223414684 0.143891264201456 no 463 0.110770218073861 522 6790032 YDR047W HEM12 SGTC_1354 1498-1681 81 µM 1.22039434687697 0.144323974608738 no 464 0.111157709674654 643 5754243 SGTC_662 k832-1615 104 µM 1.21846166090394 0.144733147095891 no 465 0.11152429277079 591 5878478 SGTC_2586 curcumin 80 µM 1.21600267540432 0.145254871784315 no 466 0.111991951424737 703 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3288 9119690 36.221 µM 1.21594328014171 0.145267489350753 no 467 0.112003264744761 530 17595618 YKL019W RAM2 SGTC_296 1222-0039 74.9 µM 1.21563896596447 0.145332147561756 no 468 0.1120612418437 573 5984176 SGTC_2418 pentamidine 31.67 µM 1.21530855075288 0.145402373428724 no 469 0.112124215930481 576 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2264 7948757 110.76 µM 1.21486121647714 0.145497485431702 no 470 0.112209514012503 580 2971411 SGTC_668 1682-0499 62.6 µM 1.21430026654076 0.145616813461996 no 471 0.112316541955061 651 682214 SGTC_2607 solasodine 47.35 µM 1.21332522741407 0.145824385134513 no 472 0.112502750711969 623 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1013 4112-3890 241 µM 1.21167793620074 0.146175521114199 no 473 0.112817844081454 631 705171 SGTC_754 3474-0146 171 µM 1.20867047988453 0.14681805313771 no 474 0.113394733591477 575 24762078 SGTC_1337 1486-1011 40.3 µM 1.20659301650769 0.14726300037422 no 475 0.113794458758171 592 X1337 SGTC_3067 9117431 49.47 µM 1.20555117305126 0.147486480407885 no 476 0.113995297742841 563 17150885 SGTC_1304 1165-0502 251 µM 1.20546892526498 0.147504132594052 no 477 0.11401116361984 667 767425 SGTC_2920 7982904 15.77 µM 1.20430814750126 0.147753412017936 no 478 0.114235249381916 550 6456808 SGTC_2959 9079155 11 µM 1.20397770798418 0.147824426141681 no 479 0.114299097366166 540 16189457 SGTC_1384 3089-0840 101 µM 1.20246821825878 0.148149118291248 no 480 0.11459108624119 582 1069836 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.20135854214982 0.148388114424352 no 481 0.114806075283503 671 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_208 k072-0098 12.366 µM 1.20123092856224 0.148415615683127 no 482 0.114830817570339 711 5948901 SGTC_3112 9123419 49.47 µM 1.19629944545637 0.149480982097256 no 483 0.115789862550992 645 17015854 SGTC_337 1315-0038 354 µM 1.19174338861673 0.150469769125231 no 484 0.116680939746653 624 1626437 SGTC_51 1013-0126 23.419 µM 1.19147627246157 0.150527875432248 no 485 0.116733333012869 597 1627850 SGTC_1524 corynanthine 62.1 µM 1.1910852511203 0.150612962030873 no 486 0.116810059630404 596 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_806 3966-4455 5.86 µM 1.1905263868843 0.15073462699145 no 487 0.116919782607271 556 714982 SGTC_1931 st074438 57.1 µM 1.18507915367991 0.151923918559572 no 488 0.117993076232508 604 2787313 SGTC_924 2046-0044 21.3 µM 1.18397243202462 0.152166308352293 no 489 0.118211987892833 633 3623589 SGTC_901 1112-0062 60.1 µM 1.18254335717425 0.152479678335573 no 490 0.118495086262821 621 1908457 SGTC_3221 9128209 49.47 µM 1.18073003088402 0.152877923676297 no 491 0.118854993761334 588 16460723 SGTC_1375 2910-0797 186 µM 1.17671514824105 0.153762130021869 no 492 0.119654609793817 640 742508 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.17381658722222 0.154402586543368 no 493 0.120234249296243 624 616764 SGTC_3032 9089427 49.47 µM 1.17365534886882 0.154438264949255 no 494 0.120266550908109 604 17173707 SGTC_473 2-arachidonoylglycerol 10 µM 1.17283375714438 0.154620149277959 no 495 0.120431239056014 621 5282280 An endocannabinoid. SGTC_625 k213-0058 121 µM 1.17064928401081 0.155104437185652 no 496 0.120869889304512 837 3655420 SGTC_2273 7815444 169.05 µM 1.17054892018452 0.155126711433489 no 497 0.120890069711538 630 2824616 SGTC_1475 4092-1048 11.7 µM 1.17036262334972 0.155168062823342 no 498 0.120927535169901 698 2881759 SGTC_2473 5854593 8.94 µM 1.16539056986603 0.156274373620494 no 499 0.121930466357236 625 2872951 SGTC_2011 4012611 177 µM 1.16361873223513 0.156669870459613 no 500 0.122289278319319 653 2049887 SGTC_3082 9117008 49.47 µM 1.16239719810523 0.156942915857753 no 501 0.122537080447255 653 41448529 SGTC_5 0352-0601 109.883 µM 1.16118576622742 0.157214012139502 no 502 0.12278318096796 598 762456 SGTC_850 0388-0143 75.9 µM 1.16111704068874 0.157229400881162 no 503 0.122797152838317 629 67273 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.16047259023469 0.157373751778755 no 504 0.122928223570186 600 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.16037300742733 0.15739606516797 no 505 0.12294848583872 567 4620898 SGTC_2146 5545642 200 µM 1.15965962546496 0.15755597253455 no 506 0.123093707247585 657 825326 SGTC_3000 9075062 71.4286 µM 1.15961797507446 0.157565311930112 no 507 0.123102189628151 615 17057871 SGTC_253 dyclonine 31.25 µM 1.15841890201992 0.157834339759781 no 508 0.123346564571678 711 3180 An oral anasthetic. SGTC_42 0133-0086 60.653 µM 1.15831456282862 0.157857763889929 no 509 0.123367845297466 584 162923 Model of phenazepam hydroxylation. SGTC_3268 9137683 49.47 µM 1.15826668377572 0.157868513493027 no 510 0.123377611434356 619 1953228 SGTC_2865 9030313 51.95 µM 1.15792807772019 0.157944549617764 no 511 0.123446694114509 600 42562754 SGTC_1064 honokiol 6.76 µM 1.15360043693745 0.158918465886073 no 512 0.124332009578704 679 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3122 9126309 49.47 µM 1.14872680101343 0.160019957604819 no 513 0.125334325460855 640 17591206 SGTC_1265 0819-1001 68.8 µM 1.14611955725442 0.160611266363835 no 514 0.125872843229036 627 3106768 SGTC_3274 9138298 49.47 µM 1.14278333533646 0.161369982245067 no 515 0.126564279742795 688 17015756 SGTC_558 k064-0027 21.3 µM 1.14252415621726 0.161429021852793 no 516 0.126618105498267 672 5088526 SGTC_2236 dapsone 200 µM 1.1417655193093 0.161601916201944 no 517 0.126775749185093 698 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_263 alizarin 107.927 µM 1.14131824679576 0.161703906738921 no 518 0.126868755797592 748 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1578 josamycin 24.2 µM 1.14030955404999 0.161934070613127 no 519 0.127078679420106 613 5282165 A P450 substrate. SGTC_1720 st037298 9.481 µM 1.14026222515482 0.161944875376832 no 520 0.127088535184606 627 597396 SGTC_2400 5203494 178.7 µM 1.13955265050355 0.162106921227206 no 521 0.127236360710236 619 6777674 SGTC_1677 st019204 53.9 µM 1.1379996447485 0.16246195011256 no 522 0.127560315338034 636 3945625 SGTC_2796 7949634 45.45 µM 1.13784652423242 0.162496982007038 no 523 0.12759228707498 642 2971588 SGTC_2731 amoxapine 43.43 µM 1.13453796039808 0.163255136966091 no 524 0.128284479979864 567 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_756 0508-1999 28.3 µM 1.13449461062564 0.163265085764234 no 525 0.128293566566404 657 6753853 SGTC_1406 3909-7906 11.9 µM 1.13255476107671 0.163710685572708 no 526 0.128700637763546 694 X1406 SGTC_1726 st035556 14.5795 µM 1.13246615131656 0.163731058819804 no 527 0.128719253616209 732 5919439 SGTC_2846 9008642 19.48 µM 1.13151798979628 0.163949164111696 no 528 0.128918567985062 621 2992898 SGTC_2235 salicylic acid 500 µM 1.1305260189491 0.164177548536439 no 529 0.129127320583235 671 338 A COX inhibitor and kinase inhibitor. SGTC_1268 0828-0275 2.46 µM 1.12992852522701 0.164315210830578 no 530 0.129253171550124 702 745337 SGTC_2040 5100729 123 µM 1.12814901822615 0.164725651713059 no 531 0.129628495255565 694 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_125 0133-0007 11.75 µM 1.12759480461223 0.164853615858238 no 532 0.129745540918847 735 26541 SGTC_1254 0550-0035 264 µM 1.12473505792438 0.165514934795796 no 533 0.13035066054109 729 15121435 SGTC_2674 ligustilide 100 µM 1.12234592117116 0.166068738550157 no 534 0.130857694155458 646 5319022 A signalling regulator. SGTC_803 4488-1585 147 µM 1.12203048305966 0.16614194671771 no 535 0.130924739608304 689 747204 SGTC_789 1309-1135 70.6 µM 1.11645684286407 0.167438937786687 no 536 0.132113316832444 684 3092424 SGTC_307 1501-1223 22.3 µM 1.11380344375442 0.168058672093072 no 537 0.13268175963667 683 2830329 SGTC_1444 4112-3581 28 µM 1.11341158140768 0.168150321347681 no 538 0.1327658516204 703 2877249 SGTC_1844 rapamycin 4 nM 1.11285288520747 0.168281045509482 no 539 0.132885808895769 789 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3036 9090181 49.47 µM 1.11233498867953 0.16840228170143 no 540 0.132997072734289 694 25236586 SGTC_2936 9038235 15.59 µM 1.11175143249919 0.168538955673253 no 541 0.133122519582394 664 4749415 SGTC_2318 6029776 164 µM 1.11168349288131 0.16855487236047 no 542 0.13313712982669 692 818325 SGTC_2304 7443016 91.4 µM 1.11008995270937 0.168928479241264 no 543 0.133480133164908 632 939854 SGTC_1864 st057645 30.4 µM 1.10974465162491 0.169009505453408 no 544 0.133554537931296 673 688666 SGTC_141 0443-0274 32.331 µM 1.10671012894984 0.169722641063334 no 545 0.134209637343004 803 1627241 SGTC_3227 9130768 49.47 µM 1.1049228847187 0.170143558604253 no 546 0.134596502654412 727 17720899 SGTC_2181 6316240 54.2555 µM 1.10156077020627 0.17093718818861 no 547 0.135326335608785 652 12779990 SGTC_2355 9061122 103.12 µM 1.1005039934819 0.171187129530171 no 548 0.135556295303243 708 5302957 SGTC_2816 7982706 58.44 µM 1.10024711167205 0.171247920685446 no 549 0.135612234447171 669 2981853 SGTC_2662 daunorubicin 22.37 µM 1.1001190290228 0.171278236637954 no 550 0.135640131912203 669 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2597 laccaic acid a 100 µM 1.10007597743227 0.171288427312967 no 551 0.135649509789015 727 5491415 A textile dye. SGTC_292 k038-0015 474 µM 1.09947161321867 0.171431526340655 no 552 0.135781204610627 666 46368540 SGTC_2833 9001315 45.46 µM 1.09869157430622 0.171616333862842 no 553 0.135951309476235 707 2989378 SGTC_3329 9141233 27.5565 µM 1.09828161178131 0.171713513562615 no 554 0.136040769406953 681 4909101 YNL103W MET4 SGTC_2903 5923464 63.88 µM 1.09784600936656 0.171816809587885 no 555 0.136135868490895 684 2876576 SGTC_650 1328-0195 38 µM 1.09684418399666 0.172054526724594 no 556 0.136354755866225 734 2780821 SGTC_3206 9114350 49.47 µM 1.09655365117516 0.172123504767717 no 557 0.13641827897531 659 17087243 SGTC_1636 st007707 68.9 µM 1.0947489686041 0.172552366132591 no 558 0.136813314458591 753 403051 SGTC_2223 6903751 107.57 µM 1.09451335104694 0.172608408090329 no 559 0.136864947548759 660 5598863 SGTC_1725 st036284 20.55 µM 1.09120400192756 0.173396767230868 no 560 0.137591563679944 783 707914 SGTC_2023 5144124 124 µM 1.09011822245586 0.173655922181369 no 561 0.13783053512318 709 2830192 SGTC_1664 st014217 9.02 µM 1.08637944165866 0.174550182231335 no 562 0.138655576600905 777 3982782 SGTC_2388 9080168 200 µM 1.08367045106379 0.175199955825367 no 563 0.1392554708116 666 15943073 SGTC_1680 diphenhydramine 100 µM 1.08340673570135 0.175263291951174 no 564 0.139313963623579 698 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_284 0988-0104 32.6 µM 1.08304183673542 0.175350953133607 no 565 0.139394926808987 754 4666532 SGTC_2636 apigenin dimethyl ether 100 µM 1.08275163826547 0.17542068854953 no 566 0.139459338416864 724 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_730 1436-0052 41.2 µM 1.07964252302513 0.176168919579835 no 567 0.140150698952764 690 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1822 st052468 42 µM 1.0791422202762 0.17628950945587 no 568 0.140262166215001 688 2873678 SGTC_2942 9052777 62.25 µM 1.07397711355277 0.177537526653172 no 569 0.141416469621158 799 6469503 SGTC_1588 farnesol 29.9 µM 1.07385658217494 0.177566716432698 no 570 0.141443482746853 736 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2686 alizarin 95.37 µM 1.07328671240309 0.177704766095069 no 571 0.14157124757478 673 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2762 leflunomide 42.06 µM 1.07260210382609 0.177870700487281 no 572 0.141724840210155 757 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_153 4077-0274 519.67 µM 1.070429021359 0.1783980560789 no 573 0.142213120998261 685 3121976 SGTC_2654 protoveratrine a 100 µM 1.06837531993692 0.178897345103149 no 574 0.142675622593694 717 5702278 A heart drug and vasodilator. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.06801147702626 0.178985892995381 no 575 0.142757667366631 699 279621 SGTC_74 000s-0487 160.283 µM 1.06496637595386 0.179728055517733 no 576 0.143445572937738 724 677548 SGTC_2446 5162541 200 µM 1.06278994914676 0.180259684770098 no 577 0.143938609262384 696 1549321 SGTC_638 3970-0837 4.09 µM 1.05908746871894 0.181166343337223 no 578 0.144779973213574 745 4118451 YLR208W SEC13 SGTC_1898 st060199 18.6 µM 1.05837700670212 0.181340646440684 no 579 0.144941798937846 721 688866 SGTC_2082 5219693 150 µM 1.05786658057921 0.181465937999397 no 580 0.145058136561799 741 2834649 SGTC_577 r071-0003 38.6 µM 1.05738239236282 0.181584839149859 no 581 0.145168552048128 870 4568517 YMR134W ERG29 SGTC_2431 5490079 200 µM 1.05689827113435 0.181703772584758 no 582 0.145279008790751 763 5722345 SGTC_47 0149-0135 24.25 µM 1.05470511319084 0.182243173164788 no 583 0.145780106269586 707 5239155 SGTC_505 gw-5074 63.9 µM 1.05446271750954 0.182302851003998 no 584 0.145835560571211 753 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2502 avocadyne acetate 18.59 µM 1.05288079108674 0.182692621277947 no 585 0.146197815444395 793 3952079 SGTC_2990 9074105 71.4286 µM 1.05073379342972 0.183222450844747 no 586 0.146690435354753 713 6502001 SGTC_2725 haloperidol 53.21 µM 1.04571712520298 0.184464179866107 no 587 0.147845826888861 752 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_540 1187-0821 17.3 µM 1.04376752632488 0.184948154979286 no 588 0.148296479664657 739 847520 SGTC_1709 st033179 39.1045 µM 1.04351910314365 0.185009881028139 no 589 0.148353968999563 786 573381 SGTC_317 4495-0002 170 µM 1.04268793190384 0.18521649632394 no 590 0.148546424475585 709 15991618 SGTC_987 1497-1013 404 µM 1.04108994749415 0.18561413096839 no 591 0.148916902290696 734 1676435 SGTC_1006 4099-6547 255 µM 1.03956510034332 0.185994059986619 no 592 0.149270999065635 757 3146833 SGTC_2291 7917025 104.35 µM 1.03941322142071 0.186031928335482 no 593 0.14930629882866 756 2964612 SGTC_2779 methotrexate 400 µM 1.03853437683885 0.186251146675876 no 594 0.149510669683908 797 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2784 7567673 72.73 µM 1.03807989124326 0.186364575993879 no 595 0.149616431213136 791 3471247 SGTC_1843 st055809 45.5 µM 1.03804908183214 0.186372266874131 no 596 0.14962360255457 715 16413835 SGTC_1462 k081-0014 26.5 µM 1.0361040877905 0.186858189073371 no 597 0.150076792684338 599 3270634 SGTC_2417 cerulenin 830 nM 1.0345947248684 0.187235816357015 no 598 0.150429109287421 748 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.03396705648692 0.187392991440021 no 599 0.150575782190681 792 6728940 SGTC_1953 st076800 12.1 µM 1.03368975143717 0.187462457650045 no 600 0.150640612876994 768 297591 SGTC_613 3914-0030 117 µM 1.03253346748275 0.187752283683119 no 601 0.150911138907876 529 1145395 SGTC_1640 st009078 66.4 µM 1.03175798953579 0.187946814515522 no 602 0.151092752009853 698 690618 SGTC_162 k030-0015 37.8 µM 1.03128913880691 0.188064487383911 no 603 0.151202625045539 810 1809920 YMR134W ERG29 SGTC_1229 0139-0193 12.2 µM 1.03122589130414 0.188080364818617 no 604 0.151217450877775 822 3090752 SGTC_3272 9137413 49.47 µM 1.03045138411947 0.188274861522451 no 605 0.151399081351 730 17614870 SGTC_3223 9129970 49.47 µM 1.02974978097106 0.188451157412106 no 606 0.151563740206555 793 17248386 SGTC_796 1234-0020 70.7 µM 1.02551961390457 0.189516252077113 no 607 0.152559037758635 734 46495034 SGTC_1073 triclabendazole 3.09 µM 1.02413852432096 0.189864790901117 no 608 0.152884925242509 834 50248 An antihelmetic and likely tubulin inhibitor. SGTC_574 1315-0397 40 µM 1.0214164850222 0.190552891587402 no 609 0.153528579161992 896 6794277 SGTC_1647 st011722 22.4 µM 1.02008493758363 0.190890048620049 no 610 0.153844089830217 740 2854783 SGTC_2682 pyrogallin 40.03 µM 1.0196881440153 0.190990590235221 no 611 0.153938193152839 837 822798 An ATP competetive kinase inhibitor. SGTC_1839 st053978 48 µM 1.01836577441906 0.19132589353683 no 612 0.15425208046803 780 3788398 SGTC_978 1416-0512 87.4 µM 1.01815150762489 0.191380257500591 no 613 0.154302980221346 814 6814003 SGTC_459 nigericin 15.3 µM 1.01725646394672 0.191607451134039 no 614 0.154515720758162 817 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3188 9110789 49.47 µM 1.01563872515254 0.192018509186804 no 615 0.154900728430136 784 849217 SGTC_1702 st027038 51 µM 1.01539683063206 0.192080019529991 no 616 0.154958351617991 786 5521182 SGTC_1857 st056007 79.3 µM 1.01483189392062 0.192223721870139 no 617 0.155092983814858 764 619834 SGTC_2332 7982454 138.89 µM 1.01423387163022 0.192375911785575 no 618 0.155235584884692 797 2981748 SGTC_1772 st048439 82.2 µM 1.01344614134076 0.192576492656219 no 619 0.155423554710165 779 2927068 YDL195W SEC31 SGTC_554 4483-2211 187 µM 1.01190661702352 0.192968872766124 no 620 0.155791352575259 773 747107 SGTC_1366 1683-0113 21.9 µM 1.01015078268815 0.193416979513636 no 621 0.156211527613165 763 708623 SGTC_855 0428-0020 25 µM 1.01004139954969 0.193444916192025 no 622 0.156237727921019 716 6812414 SGTC_171 k064-0041 9.68 µM 1.0098384244843 0.193496762962735 no 623 0.156286353771618 688 53325 SGTC_3276 9139060 49.47 µM 1.00862065824208 0.193808000039515 no 624 0.156578298017376 741 4870619 SGTC_952 1185-0122 232 µM 1.00653459583409 0.194341865150571 no 625 0.157079239195346 778 678600 SGTC_2614 arthonioic acid 13.39 µM 1.00578341884822 0.194534325425642 no 626 0.157259882570382 732 6710684 SGTC_1614 st002383 48.6 µM 1.00482900274091 0.19477902517873 no 627 0.157489597918603 794 1947235 SGTC_1111 tnp00062 510.699 nM 1.00427641860777 0.194920786034126 no 628 0.157622698366647 823 676306 SGTC_2321 7390090 138.78 µM 1.00148622072356 0.195637545768524 no 629 0.158295899264848 705 649046 SGTC_2306 7482397 179.52 µM 1.00144641818586 0.195647782002342 no 630 0.158305516191549 793 891448 SGTC_2934 9036370 36.88 µM 0.996557555339977 0.19690754883404 no 631 0.159489658485116 825 6462800 SGTC_3356 9151811 4.48 µM 0.996247070253228 0.196987720426773 no 632 0.159565057073469 793 1859254 YPR165W RHO1 SGTC_783 0848-0141 92.7 µM 0.992974518563262 0.1978339401589 no 633 0.160361186237247 769 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_137 0438-0332 85.389 µM 0.992108006094762 0.198058371050831 no 634 0.160572420736276 873 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1394 3474-0001 65.7 µM 0.991387976462043 0.198244979090558 no 635 0.160748084510647 706 5017666 YIL048W NEO1 SGTC_2882 9058044 58.44 µM 0.990171652246973 0.198560451350273 no 636 0.161045112922378 772 18076804 SGTC_2753 fluvastatin 17.09 µM 0.990135063220177 0.198569945962264 no 637 0.161054053569862 817 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_97 0535-0701 19.132 µM 0.990002442663747 0.198604362420142 no 638 0.161086462548102 766 2832013 YGL099W LSG1 SGTC_3065 9113888 49.47 µM 0.988506468933938 0.198992832786967 no 639 0.161452333936467 759 16648368 SGTC_3031 9088762 49.47 µM 0.983224018882259 0.200368223713863 no 640 0.162748597973705 862 205253 SGTC_1189 1431-2119 7.28 µM 0.982878025243089 0.200458508874801 no 641 0.162833737142847 848 3107275 SGTC_674 0498-0004 451 µM 0.97982124870874 0.201257219136043 no 642 0.163587180706988 787 4231473 SGTC_1765 st044815 90.4 µM 0.979463358104221 0.201350857580615 no 643 0.163675542468237 805 645695 SGTC_2826 7992541 19.48 µM 0.97894517066906 0.201486482333278 no 644 0.163803535777528 787 2985066 SGTC_1049 3226-0134 66 µM 0.978911859772036 0.20149520263795 no 645 0.163811765855833 856 5702385 SGTC_779 1360-0071 233 µM 0.978078493057084 0.201713439425344 no 646 0.164017751986519 878 7566 SGTC_76 0433-0009 400.328 µM 0.97795246896365 0.201746454133604 no 647 0.164048916418149 732 2841569 SGTC_2552 juarezic acid 87.02 µM 0.977639380665404 0.201828488318592 no 648 0.164126356483364 984 1549512 SGTC_2536 dehydroabietamide 32.04 µM 0.977194578108742 0.20194506810186 no 649 0.164236415857103 868 3983547 SGTC_3196 9111891 49.47 µM 0.976929983935544 0.202014435586688 no 650 0.164301908207398 817 18891510 SGTC_3333 9141820 12.094 µM 0.973869912805992 0.202817716626404 no 651 0.165060567174581 778 1939433 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.972680893460252 0.203130353081416 no 652 0.165355962080622 869 6708561 SGTC_2976 9009005 19.48 µM 0.971189130827786 0.203522998405343 no 653 0.165727052704627 851 2993148 SGTC_2962 9082311 13.18 µM 0.970221671450999 0.203777884225657 no 654 0.165968005347805 771 16459453 SGTC_2083 5306046 65.942 µM 0.968995599264993 0.204101177138563 no 655 0.166273692439993 815 539837 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.968993128105812 0.204101829046607 no 656 0.166274308921948 877 4174840 SGTC_451 chloral hydrate 100 µM 0.966309185286111 0.204810602813277 no 657 0.166944745601691 898 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3123 9126162 49.47 µM 0.966267406024002 0.204821647409499 no 658 0.166955195633541 819 25239884 SGTC_10 0279-0212 42.575 µM 0.965622326273465 0.204992223024901 no 659 0.167116599655837 938 39851 YBR002C RER2 SGTC_1311 1190-0148 100 µM 0.96539061677028 0.2050535135629 no 660 0.167174599744488 960 1961333 SGTC_3074 9116018 49.47 µM 0.964732382888829 0.205227685420609 no 661 0.16733943556106 801 17027303 SGTC_1468 k284-1086 134 µM 0.964282526505034 0.205346770135179 no 662 0.16745214943695 886 15996457 SGTC_1886 st057356 49.9 µM 0.962584453352849 0.205796648998086 no 663 0.167878051261427 796 24207747 SGTC_121 0557-0495 61.343 µM 0.962205661396558 0.205897083933204 no 664 0.167973152925687 1053 3104427 SGTC_1807 st050092 58.9 µM 0.962088362779566 0.20592819101417 no 665 0.168002609614113 803 5008496 SGTC_1492 4158-0558 28.5 µM 0.959855352967228 0.206520906980048 no 666 0.168564009601327 839 3967268 SGTC_3198 9112019 49.47 µM 0.959176481136747 0.206701302537856 no 667 0.168734923243994 827 45595555 SGTC_2477 5967686 25.23 µM 0.957985204417708 0.207018084076627 no 668 0.169035109678521 827 776118 SGTC_929 2805-0021 398 µM 0.957493189809873 0.207149003235028 no 669 0.169159191064381 826 3098024 SGTC_2923 7992654 58.14 µM 0.956882175694527 0.20731165488326 no 670 0.169313364380113 821 2985126 SGTC_1933 st074711 15.9 µM 0.955628391177252 0.207645648052163 no 671 0.169630006205836 881 17250958 SGTC_2663 amphotericin b 100 µM 0.955405940351513 0.207704939475708 no 672 0.169686225556126 816 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_786 4544-0069 423 µM 0.954819826902658 0.207861208406396 no 673 0.169834409523533 870 748821 YLR208W SEC13 SGTC_765 1319-0117 244 µM 0.953586710751552 0.208190207102381 no 674 0.170146442608193 799 3487746 YGL099W LSG1 SGTC_2646 retinol 96.75 µM 0.951114342363979 0.208850766530861 no 675 0.170773167397631 836 445354 A vitamin A analog and teratogen. SGTC_203 k066-0004 30.888 µM 0.951059522438321 0.208865427122112 no 676 0.170787080514086 1007 6795412 SGTC_1165 k072-0275 30.3 µM 0.950798539812709 0.208935230488542 no 677 0.170853326991476 841 6153523 YGL055W OLE1 SGTC_2026 5148700 152 µM 0.950268551572128 0.209077025360841 no 678 0.170987907052828 858 79838 SGTC_135 0933-0004 26.348 µM 0.949275677750467 0.20934281469638 no 679 0.171240210247065 803 21230617 YGL099W LSG1 SGTC_2185 6113692 200 µM 0.946817844677696 0.210001623990966 no 680 0.171865803551539 789 874150 SGTC_1442 4112-3290 3 µM 0.945249989628109 0.210422515023221 no 681 0.172265631819014 885 704353 SGTC_1694 st024011 44.9 µM 0.945148957534625 0.210449654083334 no 682 0.172291416967032 907 2787533 SGTC_1387 3342-1166 1.8 µM 0.944280849871018 0.210682928268185 no 683 0.172513074618738 799 3418228 SGTC_487 nimodipine 119 µM 0.942916872845159 0.211049756609306 no 684 0.172861711891189 758 4497 L-type voltage-gated calcium channels inhibitor SGTC_2943 9068529 45.32 µM 0.939414370677177 0.211993433718933 no 685 0.173759018789222 962 3270634 SGTC_2210 7115885 190.385 µM 0.939304084407629 0.212023188105449 no 686 0.173787321087802 885 2927039 SGTC_1778 st046819 58.9 µM 0.938535952514481 0.21223049190998 no 687 0.173984524849518 917 671715 SGTC_3154 9100113 49.47 µM 0.938456863018553 0.212251843346594 no 688 0.174004837701416 852 25237525 SGTC_2149 5554786 194.827 µM 0.937634511638841 0.212473924248611 no 689 0.174216134628288 894 745063 YPR165W RHO1 SGTC_1820 st053765 18.6 µM 0.936746819797708 0.212713803019391 no 690 0.174444403215074 838 3690829 SGTC_3062 9077494 49.47 µM 0.936319995094675 0.212829199073323 no 691 0.174554228133997 843 16459633 SGTC_1513 0337-0559 19 µM 0.933079190650347 0.213706572182899 no 692 0.175389541222034 805 775073 SGTC_3267 9137951 49.47 µM 0.932791794727915 0.213784479575401 no 693 0.17546373927692 866 16643986 SGTC_1195 1502-0147 41.1 µM 0.931242760636108 0.214204677048438 no 694 0.175864001623993 912 817940 SGTC_1897 st060201 15 µM 0.931136486778978 0.214233522943275 no 695 0.175891483417452 815 611878 SGTC_533 1222-0222 6.71 µM 0.928219126769545 0.215026263575889 no 696 0.176646957432256 914 3982874 SGTC_504 lovastatin 124 µM 0.927595669932911 0.215195897505795 no 697 0.176808672335732 821 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3284 9108171 64.8615 µM 0.924808974776756 0.21595506738567 no 698 0.177532640696397 832 8687505 SGTC_1136 pergolide 1.05886 µM 0.92289439861375 0.216477546904653 no 699 0.178031119978086 904 47811 A dopamine receptor agonist. SGTC_2881 9058953 51.95 µM 0.920088969380876 0.217244456009071 no 700 0.178763134085306 951 17122249 SGTC_1707 st032323 6.317 µM 0.919128839366256 0.217507282954557 no 701 0.179014093165708 870 3132057 YMR211W DML1 SGTC_1122 capsaicin 818.572 nM 0.917810123007297 0.217868568678117 no 702 0.179359140789897 897 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1666 st014829 29 µM 0.917710815585304 0.217895789712432 no 703 0.179385141910536 916 3858230 SGTC_2486 5283202 22.39 µM 0.917678932911503 0.217904529448523 no 704 0.179393490079649 823 1377751 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.917593565589928 0.217927931488046 no 705 0.179415843887943 882 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_8 0354-0001 70 µM 0.914958886826778 0.21865089736594 no 706 0.180106606968977 967 4993152 SGTC_2684 capsaicin 100 µM 0.914727951972238 0.218714332510649 no 707 0.180167233213738 871 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_124 0136-0217 7.121 µM 0.913900293997204 0.218941767612049 no 708 0.180384619588641 1003 3976905 SGTC_1867 st057372 64 µM 0.913797392893786 0.218970053680353 no 709 0.180411658310415 896 688837 SGTC_700 3453-2283 142 µM 0.912438310377108 0.21934384354429 no 710 0.180769015023595 941 565664 SGTC_472 calcifediol 10 µM 0.911375892665008 0.219636296561751 no 711 0.181048675596541 821 5283731 A vitamin D metabolite. SGTC_3171 9103192 49.47 µM 0.911179770248643 0.219690307890679 no 712 0.181100330589554 913 13018434 SGTC_843 0310-0051 143 µM 0.910822258553198 0.219788784800817 no 713 0.181194516266244 880 2065037 SGTC_2797 7859098 81.82 µM 0.910789683938524 0.219797758766424 no 714 0.181203099502275 882 972681 SGTC_2484 5809818 12.04 µM 0.909677865138458 0.220104179292564 no 715 0.181496210452709 865 2870548 SGTC_516 3992-2719 87.3 µM 0.908123846207822 0.220532881794962 no 716 0.181906396478937 890 5350887 YDR037W KRS1 SGTC_2643 anethole 100 µM 0.907822945715141 0.220615945558946 no 717 0.181985886639161 949 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3006 9075424 71.4286 µM 0.907458704249413 0.220716518612719 no 718 0.1820821389082 865 7465181 SGTC_913 3487-1245 167 µM 0.907338989796282 0.220749579473087 no 719 0.182113780880696 851 4016153 SGTC_2733 amorolfine 100 µM 0.906506396301748 0.220979590526281 no 720 0.182333940449763 865 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_246 cycloheximide 667 µM 0.906222263223011 0.221058116095554 no 721 0.182409110736717 809 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3259 9138485 49.47 µM 0.905272468642183 0.221320725733116 no 722 0.182660529026467 974 17646153 SGTC_3135 9127742 49.47 µM 0.905179561003251 0.221346423433834 no 723 0.182685134041067 845 3643468 SGTC_3113 9123498 49.47 µM 0.904674979771748 0.221486017397792 no 724 0.182818799970511 941 8897275 SGTC_2098 5376439 882.5 nM 0.902808928298007 0.222002703332098 no 725 0.183313655889061 951 2844116 SGTC_747 3448-8087 38.7 µM 0.902441958181326 0.22210439360632 no 726 0.183411070434745 902 5168703 SGTC_123 0083-0120 66.675 µM 0.900466362997942 0.22265230304644 no 727 0.183936059075191 882 16001701 SGTC_2296 7971656 126.45 µM 0.897525786651972 0.223469264471547 no 728 0.184719209901457 883 666570 SGTC_658 3253-0951 102 µM 0.896300795586259 0.223810098384492 no 729 0.185046067160312 980 1184878 SGTC_1472 k841-0093 193 µM 0.896054709911005 0.22387860335937 no 730 0.185111772088472 959 X1472 SGTC_2286 7945697 125 µM 0.895705226539745 0.223975912511189 no 731 0.185205109124826 908 1245733 SGTC_3258 9138477 49.47 µM 0.894267862468036 0.224376380627509 no 732 0.185589295275165 922 4970355 SGTC_976 1348-1067 47.6 µM 0.892073407088702 0.224988567324095 no 733 0.186176793785707 1002 5310671 YGL099W LSG1 SGTC_2815 7968870 71.43 µM 0.889430582833817 0.225727090296988 no 734 0.186885857414025 929 2977326 YHR190W ERG9 SGTC_515 4092-1064 102 µM 0.888972768490279 0.225855163256921 no 735 0.187008857541708 992 717353 SGTC_2635 hydroquinidine 100 µM 0.886793703881526 0.226465316688137 no 736 0.187594988996215 916 442912 An experimental heart treatment. SGTC_3057 9095946 49.47 µM 0.886586027928702 0.226523515956859 no 737 0.187650909491394 945 24540043 SGTC_3175 9106517 49.47 µM 0.885018087382901 0.226963189264368 no 738 0.188073438069516 904 41468073 SGTC_2444 5485484 36.41 µM 0.884970527453542 0.226976533275756 no 739 0.188086263687698 957 6790631 SGTC_1170 0310-0127 64.8 µM 0.88230834926855 0.227724172585465 no 740 0.188805041298774 946 774975 SGTC_2575 plumbagin 510 nM 0.882134660344946 0.227772999060371 no 741 0.188851995372939 897 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1048 3161-0300 24.5 µM 0.881411908240913 0.227976238414303 no 742 0.189047457315164 967 2165101 SGTC_972 1319-0219 195 µM 0.88134732760501 0.227994403583248 no 743 0.189064928641872 890 23903702 SGTC_2824 7998404 51.95 µM 0.881218765698879 0.228030567755724 no 744 0.18909971210619 872 837851 SGTC_1192 1488-0095 21.4 µM 0.881011080378303 0.228088995980421 no 745 0.189155911376043 898 915875 SGTC_3299 9121982 43.1275 µM 0.880573784003169 0.228212048330539 no 746 0.189274276602032 935 17594604 YPL160W CDC60 SGTC_2821 7996764 71.43 µM 0.879565861238741 0.228495813324735 no 747 0.189547269787717 976 2987135 SGTC_3173 9105693 49.47 µM 0.876803993272396 0.229274389192426 no 748 0.190296554878792 967 17096658 SGTC_3058 9093861 49.47 µM 0.876773994408572 0.229282854087381 no 749 0.19030470344108 925 17217477 SGTC_113 0099-0221 2.5 µM 0.876664429609498 0.229313771897367 no 750 0.190334466242073 890 89219 SGTC_2981 9013952 38.96 µM 0.873338023251938 0.230253553914362 no 751 0.191239430649357 899 2996344 SGTC_2665 lovastatin 100 µM 0.87265171941648 0.230447717359097 no 752 0.191426470533432 931 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1834 st055981 52.8 µM 0.872511742220526 0.230487329792237 no 753 0.191464632582864 952 471719 YDL150W RPC53 SGTC_356 1634-0012 32.5 µM 0.870430069257464 0.231076875648522 no 754 0.192032710059624 991 735457 SGTC_1668 st014914 51.6 µM 0.869065605932294 0.231463758357525 no 755 0.192405623846795 964 2839556 SGTC_2929 9013348 24.6 µM 0.868068425740425 0.231746729122488 no 756 0.192678437401978 914 2995952 SGTC_2423 st077119 87.2 µM 0.867214118499453 0.23198930991337 no 757 0.192912350966976 940 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2993 9054257 71.4286 µM 0.867213008253352 0.231989625260038 no 758 0.192912655070678 988 6470217 YGL055W OLE1 SGTC_3291 9121177 71.43 µM 0.867024300608652 0.232043227949689 no 759 0.1929643475886 857 17015612 SGTC_916 4466-0038 42 nM 0.866292117849368 0.232251270825722 no 760 0.193164993835008 1039 5722064 YGL116W CDC20 SGTC_2848 9016370 25.97 µM 0.865777745814899 0.232397486869828 no 761 0.193306027697148 980 7894410 SGTC_2036 5160441 105 µM 0.865541587124867 0.232464634783674 no 762 0.193370800261986 1001 134534 YIL048W NEO1 SGTC_557 1315-0110 16.2 µM 0.864989122001815 0.232621761466079 no 763 0.193522379680528 1005 6833801 SGTC_1749 st037932 54.2 µM 0.863455087884264 0.233058365737485 no 764 0.193943651274172 893 594497 SGTC_1253 0550-0034 176 µM 0.863255924652145 0.233115083305239 no 765 0.193998385808549 896 5969915 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.86314882754096 0.233145585514735 no 766 0.194027822393878 959 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2379 9035213 200 µM 0.861297306807221 0.23367326520609 no 767 0.194537159312392 1002 646551 SGTC_2105 5350118 200 µM 0.860448917014313 0.233915275619672 no 768 0.194770815416369 970 2133313 SGTC_543 3844-1095 191 µM 0.860303128430061 0.233956877032675 no 769 0.194810984415633 962 4230703 SGTC_320 4092-0846 5.34 µM 0.859000085057119 0.234328888164291 no 770 0.195170234539372 976 1359356 SGTC_2904 7225135 42.03 µM 0.858699867785327 0.234414644789825 no 771 0.195253061720055 1011 4446116 SGTC_3051 9093778 49.47 µM 0.858644910578599 0.234430345115962 no 772 0.195268226219809 926 17217378 SGTC_3130 9127414 49.47 µM 0.857184833244188 0.234847677031857 no 773 0.195671371567713 964 1494646 SGTC_1525 8-methoxypsoralen 92.5 µM 0.857044508475338 0.234887807486821 no 774 0.195710143562441 1032 4114 Related to psoralen; DNA damaging agent. SGTC_2058 5236698 133 µM 0.853847579792119 0.235803099723342 no 775 0.196594723801879 937 766665 SGTC_1200 1643-0193 18.4 µM 0.853452692572661 0.235916293651832 no 776 0.196704155696771 1002 5403974 SGTC_1860 st056228 74.6 µM 0.852243911413453 0.236262975345522 no 777 0.197039364677892 938 688679 SGTC_340 k038-0059 454 µM 0.850949986694752 0.236634387113139 no 778 0.197398567812122 985 23733424 SGTC_26 0302-0163 425.158 µM 0.85092041602761 0.236642878912715 no 779 0.197406781475255 989 3100915 SGTC_3181 9108277 49.47 µM 0.850680441507408 0.23671179852361 no 780 0.197473445372335 965 17097298 SGTC_2338 7999974 200 µM 0.85010949485679 0.236875816224652 no 781 0.197632106623851 1047 315925 SGTC_1014 4130-3005 69.3 µM 0.848947851897593 0.2372097179814 no 782 0.197955155164917 966 743608 SGTC_1121 fusaric acid 630.51 nM 0.848710246421922 0.237278046952509 no 783 0.198021271624207 954 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1085 doxorubicin 7.67 µM 0.84751885371732 0.237620822522851 no 784 0.198352991394452 1050 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_869 0564-0080 44.1 µM 0.846434347692548 0.237933081823359 no 785 0.198655242049724 937 6843321 SGTC_1497 4476-2978 41.3 µM 0.846014691393664 0.23805397283147 no 786 0.198772274299536 1019 1528379 SGTC_1937 st074714 47.2 µM 0.845084722564733 0.238321990245849 no 787 0.199031768764133 1001 17250970 SGTC_814 3342-0569 96 µM 0.844762401659251 0.238414921822084 no 788 0.199121755403047 979 4346283 SGTC_965 1291-5240 308 µM 0.844079543045059 0.238611869178159 no 789 0.19931247912578 965 2834598 SGTC_3266 9136860 49.47 µM 0.842451361206118 0.239081821932997 no 790 0.199767677066324 952 4871271 YPR165W RHO1 SGTC_1349 flufenamic acid 69 µM 0.84196626242643 0.239221936922013 no 791 0.199903419084926 941 3371 A non-steroidal anti-inflammatory. SGTC_491 tetrandrine 80.3 µM 0.8417738392425 0.239277528486878 no 792 0.199957278967365 952 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_782 0083-0095 30.5 µM 0.840887018027862 0.239533824666929 no 793 0.200205615897232 1033 3591729 An indicator and reagent. SGTC_378 3970-0959 8.33 µM 0.835911819793728 0.240974459353033 no 794 0.201602256220479 982 6615653 SGTC_2443 5493264 126.67 µM 0.835019496538186 0.241233340862831 no 795 0.201853365566259 997 5340055 SGTC_122 0236-0016 402.397 µM 0.834893567227421 0.24126988773861 no 796 0.201888818499243 1091 6808838 SGTC_1729 st035615 45.989 µM 0.83259992927337 0.241936067554126 no 797 0.202535199453278 943 17385451 SGTC_2748 diazoxide 86.69 µM 0.832584789850836 0.241940468063404 no 798 0.202539470071305 912 3019 A potassium channel activatior. SGTC_2062 5245942 200 µM 0.831905893769922 0.242137844418632 no 799 0.202731032427417 1088 1376160 SGTC_3282 9108498 15.4605 µM 0.83116628589599 0.242352970915887 no 800 0.202939848842888 937 16459645 SGTC_2071 5230951 39.92 µM 0.830328422780437 0.242596801546405 no 801 0.203176561174897 1075 1799272 SGTC_992 3909-8734 162 µM 0.830157654337025 0.242646513995185 no 802 0.203224826732908 991 4288319 SGTC_2280 7785178 200 µM 0.829532349787905 0.242828593640766 no 803 0.203401619618167 964 2954328 SGTC_1841 st054148 70 µM 0.829139390330824 0.242943055576469 no 804 0.203512768315007 913 675442 SGTC_588 3970-1144 52.9 µM 0.829078744167137 0.242960723299482 no 805 0.203529925326512 982 1888707 SGTC_1637 st007924 17.4 µM 0.827106333106592 0.243535714017614 no 806 0.204088397476522 962 683336 SGTC_3216 9129716 49.47 µM 0.826097663477792 0.243830041833772 no 807 0.204374346502456 944 8056934 SGTC_1413 3910-0535 34.4 µM 0.826041190551242 0.24384652619602 no 808 0.204390363130973 1033 2876951 SGTC_600 1495-0418 41.6 µM 0.825613311762277 0.243971442909886 no 809 0.204511740699963 981 5377768 SGTC_2558 carylophyllene oxide 100 µM 0.824524046912355 0.244289603173886 no 810 0.204820929033928 1087 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1984 st072354 53.1 µM 0.823496437124497 0.244589959685164 no 811 0.205112871223969 994 5762938 SGTC_1684 st024538 14.6195 µM 0.823144847333756 0.244692770297977 no 812 0.205212814037127 998 6732859 SGTC_628 1636-0253 16 µM 0.822956012180436 0.244747998392748 no 813 0.205266504205002 1012 4456143 SGTC_1298 1079-1278 263 µM 0.817470736897503 0.24635518640613 no 814 0.206829732882363 1034 2840950 SGTC_3147 9097027 49.47 µM 0.817270027143923 0.246414101542605 no 815 0.206887065754728 1043 25236841 SGTC_2366 9070441 60.58 µM 0.81710273614318 0.246463212907933 no 816 0.206934859725193 1069 6837235 SGTC_3033 9090887 49.47 µM 0.816928270436605 0.246514436127392 no 817 0.2069847104232 1046 19325384 SGTC_120 rhodamine 6G 52.259 µM 0.816846435965925 0.246538464734267 no 818 0.207008095721558 1122 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2086 5274770 176.623 µM 0.816797352120148 0.24655287755673 no 819 0.207022122839298 975 689278 SGTC_2980 9014342 25.29 µM 0.815703464443614 0.246874200304441 no 820 0.207334878544454 937 2996599 SGTC_555 4296-0685 37 µM 0.815476536156716 0.246940887148116 no 821 0.207399795055095 1037 2908540 YHR072W ERG7 SGTC_675 1309-0189 238 µM 0.814493107049646 0.247229996356741 no 822 0.207681259709051 999 4246530 SGTC_114 0364-0001 490.298 µM 0.811982719585235 0.247968821843459 no 823 0.208400773587059 1011 4003655 SGTC_1514 1189-1591 158 µM 0.810995459683868 0.248259702151203 no 824 0.20868413906643 1034 767698 YMR146C TIF34 SGTC_1016 4226-1401 38 µM 0.809980156370424 0.248559034659169 no 825 0.208975790359374 1059 2901613 SGTC_2529 gangaleoidin 93.61 µM 0.808962038162655 0.248859390027847 no 826 0.209268491189932 1036 4565183 SGTC_2851 9015922 71.43 µM 0.808654999942325 0.248950007371818 no 827 0.209356809556795 1006 2996893 SGTC_3054 9094397 49.47 µM 0.80790889231309 0.249170282082456 no 828 0.209571515947771 1078 2598354 SGTC_580 1123-0028 41 µM 0.807088209040094 0.249412693564146 no 829 0.209807832388019 1140 1677248 YPR107C YTH1 SGTC_2303 7774051 200 µM 0.805466691957693 0.249892021696828 no 830 0.210275209861468 995 2953184 SGTC_990 3985-0011 41.3 µM 0.805266422997016 0.24995125605622 no 831 0.210332976711758 962 5399565 YGL099W LSG1 SGTC_579 4491-1009 110 µM 0.804939026554919 0.250048107470037 no 832 0.210427433084542 1210 1271041 SGTC_2777 climbazole 1.536 µM 0.804875501327907 0.250066902002611 no 833 0.210445763481498 1043 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_902 1120-0002 2.07 µM 0.801924262998065 0.250940879040251 no 834 0.211298385037671 1060 3280475 SGTC_2203 7227154 166.4 µM 0.801728293625434 0.250998970414345 no 835 0.211355072732279 1055 896304 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.800442335026879 0.251380344743787 no 836 0.211727280536574 1006 688662 SGTC_2380 9035439 200 µM 0.799493317472801 0.251661989407274 no 837 0.212002209977874 1090 6462575 SGTC_1752 st044819 83.042 µM 0.798825199699405 0.251860369968034 no 838 0.212195888206219 1020 441209 YML126C ERG13 SGTC_1205 4161-2785 76 µM 0.797961332262451 0.252116995725965 no 839 0.212446464860674 925 3498106 SGTC_1706 st031321 9.9705 µM 0.797090249434221 0.252375904527334 no 840 0.212699309399708 1074 6103185 SGTC_975 1335-0046 28.5 µM 0.796637717637496 0.252510464213496 no 841 0.212830732696783 1059 16486740 SGTC_744 1594-0068 283 µM 0.796530771572542 0.252542269995424 no 842 0.212861798662772 1066 668392 SGTC_276 colchicine 750 µM 0.796308913263646 0.252608257433011 no 843 0.212926253070262 1069 2833 A microtubule depolymerizer. SGTC_3245 9134821 49.47 µM 0.795744229999825 0.252776252452681 no 844 0.213090356564219 1052 17014901 SGTC_3169 9102970 49.47 µM 0.795520868506939 0.25284271942064 no 845 0.213155288358007 1081 17027839 SGTC_2768 sulfasalazine 50.2 µM 0.794063398855669 0.253276652853163 no 846 0.213579261988841 1071 5384001 An antioxidant and salicylic acid derivative. SGTC_2378 9074213 121.43 µM 0.793969107063189 0.253304739891904 no 847 0.213606708106129 1069 657714 SGTC_3138 9097216 49.47 µM 0.793653100631364 0.253398881814049 no 848 0.213698705108925 1089 25237486 SGTC_2059 5238311 157 µM 0.793379646121908 0.253480361872232 no 849 0.213778332857227 1029 703021 SGTC_3126 9127922 49.47 µM 0.793282953853537 0.253509176143771 no 850 0.213806493000958 1073 45595682 SGTC_1076 itraconazole 331 nM 0.793188310883435 0.253537381391522 no 851 0.213834058409824 1105 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3346 9158254 43.5805 µM 0.792847272894146 0.253639030304182 no 852 0.213933405207179 1014 17639500 SGTC_2698 st077697 67.5 µM 0.792098393960817 0.253862314332469 no 853 0.214151653242988 994 3154499 SGTC_343 4130-2827 29.8 µM 0.790864038469114 0.25423057199872 no 854 0.214511667786416 1043 1118244 SGTC_2118 5526350 200 µM 0.789849403523825 0.254533487849991 no 855 0.214807861519666 1052 743594 SGTC_2067 5224629 34.075 µM 0.789716392873559 0.254573211746295 no 856 0.214846707793304 1059 2835000 SGTC_1249 0481-0015 10.2 µM 0.789578870687911 0.254614286436014 no 857 0.214886875968873 1045 4227577 SGTC_380 3970-0968 6 µM 0.788201044817989 0.255026002620343 no 858 0.215289559041967 1017 2891601 SGTC_1852 st056254 31.4 µM 0.788142099976394 0.255043624037917 no 859 0.215306796009824 1028 442583 SGTC_2737 bleomycin 30.5 nM 0.786443048299022 0.255551825077137 no 860 0.215803985966655 1105 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1417 3966-0327 90.4 µM 0.785732937869584 0.255764381877419 no 861 0.216011981121349 1104 651118 SGTC_1372 2752-0194 270 µM 0.785628921138489 0.255795524872449 no 862 0.216042457928323 995 823334 SGTC_2757 clomiphene 4.22 µM 0.783940479699233 0.256301327223474 no 863 0.216537517976805 1137 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1091 telmisartan 47.6 µM 0.783861489229077 0.256325002967839 no 864 0.21656069446452 1119 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_142 0335-0849 62.6745 µM 0.782534118148696 0.256723025195363 no 865 0.216950371262483 1094 3889043 YPR107C YTH1 SGTC_1548 st061468 90.8 µM 0.780612289424431 0.257299869701597 no 866 0.217515280763285 1092 390799 SGTC_2735 sertaconazole 140 nM 0.780512108307148 0.257329957924043 no 867 0.217544751639068 1066 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2557 derrustone 83.84 µM 0.780146661434171 0.257439731101434 no 868 0.217652276856888 1102 629853 An antioxidant. SGTC_432 NS 1619 61.3 µM 0.780077935594801 0.257460377732784 no 869 0.217672501445355 995 4552 A K+/calcium channel activator. SGTC_2673 kobusone 100 µM 0.779963084103057 0.25749488336238 no 870 0.217706302276301 1106 6710676 An epoxy ketone and protein crosslinker. SGTC_720 r052-1644 49.9 µM 0.779700777532824 0.257573698950569 no 871 0.217783510538963 998 1422863 YOR257W CDC31 SGTC_2019 4016004 108 µM 0.779682268711384 0.257579260792823 no 872 0.217788959088778 1052 45595336 SGTC_1234 0326-0494 15.5 µM 0.779166304446055 0.257734331521315 no 873 0.217940878146349 1072 1547813 SGTC_3256 9138902 49.47 µM 0.778705317878504 0.257872919931035 no 874 0.218076661397019 1099 17228773 SGTC_2212 7123476 200 µM 0.77824627802759 0.258010961504714 no 875 0.218211919686619 1018 1085715 SGTC_578 3460-0051 92 µM 0.77722441084908 0.258318392991842 no 876 0.218513191266473 1155 2876744 SGTC_3172 9105863 49.47 µM 0.775941727331303 0.258704560296671 no 877 0.218891696715284 1055 2348785 SGTC_821 1114-0266 29.2 µM 0.775429541496989 0.258858843447763 no 878 0.219042942295921 1044 3123235 SGTC_2460 5552655 174.22 µM 0.775029061895739 0.258979511050434 no 879 0.21916124351324 1086 5401989 SGTC_250 brefeldin a 552.239 µM 0.77322081364557 0.259524712263902 no 880 0.219695855133908 987 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1653 st012112 65 µM 0.77320399369455 0.259529786393566 no 881 0.219700831492906 1050 720429 SGTC_2707 st078556 66.6 µM 0.77120495595679 0.260133207302575 no 882 0.22029272855416 1050 17250899 SGTC_1155 4088-0394 48.2 µM 0.770438642735512 0.260364714914627 no 883 0.220519869180489 1072 2326248 SGTC_1692 fluoroquinolonic acid 71 µM 0.770059531743118 0.260479285744935 no 884 0.220632289944578 1070 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2260 7964312 200 µM 0.767155113036104 0.261357888343347 no 885 0.221494648604864 1028 231951 SGTC_332 4112-0506 40.9 µM 0.764605211502554 0.262130500432317 no 886 0.222253332462996 1073 2790355 SGTC_926 2268-1401 59.4 µM 0.764046456448443 0.262299957646696 no 887 0.222419779250276 1118 2931578 SGTC_1624 st003710 6.25 µM 0.760071015615284 0.26350723263887 no 888 0.223606068402585 1127 24207033 SGTC_1235 benzylparaben 21.5 µM 0.759838767794386 0.263577850000849 no 889 0.223675483247077 1056 7180 SGTC_3325 9138760 55.175 µM 0.758695317410653 0.263925668717253 no 890 0.22401741933611 1084 43844959 SGTC_893 0958-0369 48.9 µM 0.758562219814186 0.263966170003202 no 891 0.224057239974457 1117 6819948 SGTC_2754 granisetron 64.02 µM 0.757849456330301 0.264183116147144 no 892 0.224270555637993 1087 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1066 ketoconazole 628 nM 0.753132202478095 0.265621207866321 no 893 0.22568523752568 1145 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2868 9035608 32.47 µM 0.752763385397469 0.26573381174125 no 894 0.225796056397026 1134 6462614 SGTC_485 niflumic acid 177 µM 0.752658779237837 0.265765753546798 no 895 0.225827493125855 1080 4488 A COX2 inhibitor. SGTC_1368 1852-0141 284 µM 0.750813015053162 0.266329683161 no 896 0.22638259776695 1085 2838987 SGTC_1244 0416-0015 52.5 µM 0.750130121415266 0.266538478527997 no 897 0.22658816986008 1104 96201 SGTC_770 0389-1121 67.2 µM 0.749639873009172 0.266688423466688 no 898 0.226735814738716 1153 6753108 SGTC_93 0109-0045 59.227 µM 0.749191784974986 0.266825510732299 no 899 0.226870809927443 1224 88733 SGTC_2157 5649910 96.377 µM 0.747918809406498 0.267215156808123 no 900 0.227254565694493 1104 2858091 SGTC_2386 9075165 157.42 µM 0.746066566451839 0.267782623749695 no 901 0.227813602301342 1103 16452277 SGTC_1631 benzylvanillin 81.9 µM 0.745983119351362 0.267808203510427 no 902 0.227838806178482 1103 75506 SGTC_826 1683-5028 118 µM 0.745743465532003 0.26788167351005 no 903 0.227911198548181 1103 722377 SGTC_3203 9113543 49.47 µM 0.744744563623601 0.268188013369575 no 904 0.22821307677443 1097 17018012 SGTC_500 h-89 112 µM 0.744112206000561 0.268382033746912 no 905 0.22840429775826 1145 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_763 3453-1109 128 µM 0.742221145763923 0.268962670956604 no 906 0.228976679396459 1144 1560353 SGTC_298 1391-0729 10 µM 0.742115408836004 0.268995155369171 no 907 0.229008707340976 1100 3237558 SGTC_1041 0206-0046 107 µM 0.741908540371228 0.269058715024872 no 908 0.229071375515548 1096 50494 SGTC_2471 5466956 24.79 µM 0.741361172218672 0.269226928437908 no 909 0.229237240141043 1097 724419 SGTC_1757 st041620 31.8375 µM 0.741334429224759 0.269235148262139 no 910 0.229245345583264 1149 5289815 SGTC_701 4424-0219 185 µM 0.740658564106302 0.269442926413834 no 911 0.229450244564127 1173 2911779 SGTC_1999 st074831 12.5 µM 0.740350253282539 0.269537735703014 no 912 0.229543747844279 1084 17112523 SGTC_2774 tamoxifen 10.92 µM 0.737393734322411 0.270447748832428 no 913 0.230441472335051 1178 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1515 3460-0031 42.1 µM 0.736954823773411 0.270582975760755 no 914 0.230574911293845 1071 2876596 SGTC_643 k048-0106 28.4 µM 0.735970512476414 0.270886361657235 no 915 0.23087432163869 1128 6763920 SGTC_1787 fluconazole 80 µM 0.735883425177141 0.270913212006399 no 916 0.230900822527446 1078 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2323 6148992 148.28 µM 0.734024506031413 0.271486661799426 no 917 0.231466901291802 1078 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1108 betulinic acid 729.144 nM 0.73288625128611 0.271838095215939 no 918 0.231813904660777 1162 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3092 9117248 49.47 µM 0.732373218452398 0.271996566840239 no 919 0.231970400299807 1188 17141857 SGTC_178 4092-0806 87.505 µM 0.732276691866546 0.272026388243588 no 920 0.231999851363207 1112 2169044 SGTC_1759 st043059 70 µM 0.73162614241062 0.272227414621659 no 921 0.232198393696372 1150 669426 SGTC_1441 4106-0040 13 µM 0.730149980368512 0.272683837310752 no 922 0.232649256698702 1146 2904180 SGTC_61 0978-8327 98.565 µM 0.728276106193895 0.273263777295317 no 923 0.233222292895218 1192 6150059 YHR072W ERG7 SGTC_185 k048-0037 25.491 µM 0.725615862917908 0.274088136388361 no 924 0.23403714689046 1169 6827589 SGTC_2467 5474540 200 µM 0.725207317533605 0.274214845630661 no 925 0.234162427172548 1150 5413519 SGTC_308 4092-1169 104 µM 0.723579096078531 0.274720121314582 no 926 0.234662089348259 1146 2268590 YDL196W YDL196W SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.722725843472494 0.274985089009524 no 927 0.234924167394831 1196 6708784 An antioxidant flavonoid SGTC_3120 9124077 49.47 µM 0.722605797989 0.275022377842123 no 928 0.234961052551889 1216 18774327 YGL155W CDC43 SGTC_2508 celastrol 40.54 µM 0.722573706355779 0.275032346648575 no 929 0.234970913564288 1116 122724 Celastrol is a natural product and antioxidant. SGTC_2087 5276107 200 µM 0.721871192745762 0.275250617031226 no 930 0.235186836939066 1165 144405 SGTC_1381 2324-0066 62.1 µM 0.721157609420053 0.27547241402659 no 931 0.235406274812497 1124 10885928 SGTC_2581 avocatin a 64 µM 0.720480260713752 0.275683029826922 no 932 0.235614674478065 1156 6710728 A skin care supplement. SGTC_3310 9130229 44.1445 µM 0.718331366476612 0.276351733618823 no 933 0.236276497175995 1143 7761258 SGTC_1476 4112-3294 3.34 µM 0.717972113143112 0.276463605470835 no 934 0.236387240852188 1178 704369 SGTC_1803 st050068 52.4 µM 0.716964515992178 0.276777490681747 no 935 0.236697995837147 1246 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_724 3910-0327 137 µM 0.716930043024752 0.276788232738633 no 936 0.236708631685655 1178 2885483 SGTC_429 1112-0049 25.5 µM 0.716176843707985 0.277022986732745 no 937 0.236941079774513 1120 2836170 SGTC_1386 3228-0095 33.8 µM 0.715473813125932 0.27724219224749 no 938 0.237158158244155 1142 870181 SGTC_1485 3909-9022 254 µM 0.714037967249358 0.277690153597684 no 939 0.237601851229611 1194 714516 SGTC_2233 sulbentine 40.3845 µM 0.712568032818427 0.278149115959068 no 940 0.238056549433906 1170 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1770 st043884 66.3 µM 0.711562484314961 0.278463294568524 no 941 0.238367872579471 1178 670149 SGTC_1246 0422-0085 105 µM 0.710764870113686 0.27871262805018 no 942 0.238614976650799 1177 264295 SGTC_1224 0823-0416 294 µM 0.71027911256815 0.278864528654212 no 943 0.238765534943146 1182 3598164 SGTC_1023 4482-3888 16 µM 0.709345069571839 0.279156725165092 no 944 0.239055183211237 1160 3303168 SGTC_245 methotrexate 289.6 µM 0.70930179240348 0.279170267161255 no 945 0.239068608186639 1159 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_293 4049-0273 38.5 µM 0.708597169681684 0.279390797809681 no 946 0.239287246600353 1107 1380311 SGTC_1274 0865-0114 173 µM 0.707521312733791 0.279727679360523 no 947 0.239621286445279 1189 870624 SGTC_2166 5933061 31.504 µM 0.705431221937199 0.280382709365103 no 948 0.24027095986461 1377 2877375 SGTC_654 1124-0271 80.9 µM 0.704407176908775 0.280703913756262 no 949 0.240589618902257 1182 5403748 SGTC_2618 avocadyne 43.43 µM 0.702027700166759 0.281450952594275 no 950 0.24133094443985 1143 3015189 SGTC_1079 idarubicin 2.36 µM 0.701608976879649 0.281582510330803 no 951 0.241461525901873 1164 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_583 1488-1091 88.9 µM 0.70083486667673 0.281825804360496 no 952 0.241703038009467 1290 4303273 SGTC_853 0419-0306 21 µM 0.697834928652109 0.282769606554778 no 953 0.242640216292922 1146 762713 SGTC_2994 9053520 71.4286 µM 0.696211437182774 0.283281001149405 no 954 0.243148213062574 1175 4647384 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.695766503000925 0.283421231387045 no 955 0.243287535021297 1213 2724 A muscle relaxant with antifungal properties. SGTC_1297 1068-0111 14.1 µM 0.695365563066564 0.283547624422177 no 956 0.243413118039142 1170 767057 SGTC_177 1327-0068 8.361 µM 0.693612061676601 0.284100718531099 no 957 0.243962763749388 1202 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.693482207138177 0.284141698110893 no 958 0.244003494059741 1196 688667 SGTC_1316 1272-0050 65.9 µM 0.692173660178663 0.284554807902748 no 959 0.244414138925029 1198 7340392 SGTC_200 k038-0079 37.545 µM 0.692124259502731 0.284570409370523 no 960 0.244429649010415 1157 3436683 SGTC_3046 9092212 49.47 µM 0.691486538065032 0.284771847944289 no 961 0.244629918853588 1222 25236637 SGTC_795 0685-0265 78 µM 0.690669118014804 0.285030147811514 no 962 0.244886750364453 1265 302754 SGTC_1737 st035557 69.7 µM 0.69010003896403 0.285210039335403 no 963 0.245065639342744 1094 5716916 SGTC_1403 3909-7815 62.9 µM 0.690049224399988 0.28522610495314 no 964 0.245081616227507 1157 6615483 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.689703939059358 0.285335282363669 no 965 0.245190194114147 1212 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_954 1189-0853 2.85 µM 0.689578462117622 0.285374962444064 no 966 0.245229657803182 1189 2828194 SGTC_1365 1672-3266 55.4 µM 0.688128390143351 0.285833715134567 no 967 0.245685966875925 1205 6415873 SGTC_2197 6588183 93.1375 µM 0.687578298009843 0.286007836990976 no 968 0.245859189243069 1192 884136 SGTC_1740 st038286 13.222 µM 0.687491317967428 0.28603537358736 no 969 0.245886584998917 1221 716786 SGTC_909 3448-9333 149 µM 0.686858623941121 0.286235713071678 no 970 0.246085911396941 1167 3344074 SGTC_2849 9019321 12.99 µM 0.686238652504626 0.286432088624824 no 971 0.246281313665393 1185 16489627 SGTC_1282 0886-0010 32.4 µM 0.686220238579882 0.286437922201197 no 972 0.246287118628147 1262 2836211 YNL267W PIK1 SGTC_1356 1502-0781 85.8 µM 0.684436905281231 0.287003153512468 no 973 0.246849659224372 1189 567702 SGTC_2142 5622915 118.518 µM 0.682372539283856 0.287658117730404 no 974 0.247501707629479 1203 5322196 SGTC_797 k781-0471 270 µM 0.682011953847996 0.287772593592595 no 975 0.247615696093968 1207 23738129 SGTC_349 k015-0014 24 µM 0.679817642330262 0.288469690124697 no 976 0.248309967177852 1202 2196908 SGTC_2141 5621638 7.665 µM 0.678805079643447 0.288791632700858 no 977 0.248630687409681 1228 2856238 SGTC_492 tmb-8 126 µM 0.677646153701398 0.289160318682404 no 978 0.248998037525068 1126 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3241 9133421 49.47 µM 0.677374368159339 0.289246813108154 no 979 0.249084228432966 1234 17018221 SGTC_899 1083-0020 478 µM 0.676172499576512 0.289629447654678 no 980 0.24946556526983 1260 767123 SGTC_3338 9144300 39.5675 µM 0.676029559888435 0.289674970650882 no 981 0.249510938756696 1212 4901274 SGTC_3016 9080866 49.47 µM 0.675990047084816 0.2896875551606 no 982 0.249523482118694 1230 17066299 SGTC_922 1866-0035 480 µM 0.675419958385974 0.289869152370981 no 983 0.249704494384309 1221 3156169 SGTC_2476 5806916 10.51 µM 0.675373134288476 0.289884070186539 no 984 0.249719364881468 1155 2870194 SGTC_1193 1488-0126 41.5 µM 0.674430056374026 0.290184604554534 no 985 0.250018969680056 1254 1384710 SGTC_358 0075-0058 9.45 µM 0.67427937079758 0.290232637645762 no 986 0.250066858387175 1241 1069125 SGTC_1993 st073995 70.8 µM 0.673529231394588 0.290471810258034 no 987 0.250305329220424 1233 3098394 SGTC_611 3453-1652 23.7 µM 0.67351544554236 0.290476206568588 no 988 0.250309712898704 1232 1560575 SGTC_2064 5220758 200 µM 0.672654249185502 0.290750903949522 no 989 0.250583640099125 1281 788518 SGTC_1518 st038567 90.8 µM 0.671124682992081 0.291239091724811 no 990 0.251070551961751 1232 77966 SGTC_2872 9044037 25.97 µM 0.670407352237717 0.291468172100028 no 991 0.251299074528809 1229 6465195 SGTC_2429 5902844 64.44 µM 0.669713476548738 0.291689842012629 no 992 0.251520229525509 1252 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_9 0092-0002 10.449 µM 0.668230743444602 0.29216378846703 no 993 0.25199315694517 1216 759368 SGTC_870 0573-2213 57.6 µM 0.666622888809839 0.292678133841464 no 994 0.252506522500044 1243 3916321 SGTC_1264 0783-0040 158 µM 0.665040265071723 0.293184818322426 no 995 0.253012369831251 1200 2855798 SGTC_35 0133-0054 64.071 µM 0.664831249814022 0.293251765938903 no 996 0.253079216330684 1191 99677 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.662637487574795 0.293954855407026 no 997 0.253781377500881 1284 364106 SGTC_1320 1313-0481 95.3 µM 0.662282492932056 0.294068702589876 no 998 0.253895097302577 1268 6813365 YLR208W SEC13 SGTC_3229 9132204 49.47 µM 0.661692199519534 0.294258055460395 no 999 0.254084252448836 1247 17682924 SGTC_1124 fisetin 1.16336 µM 0.659410293296773 0.294990568847033 no 1000 0.254816167023002 1255 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1868 st057644 42.7 µM 0.65708966472228 0.295736372914293 no 1001 0.255561632025014 1257 688665 SGTC_1217 1183-1422 255 µM 0.656047083018428 0.29607171985108 no 1002 0.255896915292745 1284 2849664 SGTC_2029 5175081 200 µM 0.655346881035698 0.296297038091976 no 1003 0.256122221642188 1258 1380876 SGTC_1216 1165-0504 9.65 µM 0.654203375385503 0.296665176140957 no 1004 0.256490393618522 1257 6304004 SGTC_2397 5161689 200 µM 0.651720216216486 0.297465320157836 no 1005 0.257290839282871 1330 2259942 SGTC_956 1185-0240 191 µM 0.651377004019085 0.297575990296362 no 1006 0.257401575679904 1282 1416193 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.651171503975422 0.297642263597504 no 1007 0.257467891510125 1288 229346 A bile salt which induces apoptosis. SGTC_1976 st070609 63.5 µM 0.65102343736256 0.297690018921255 no 1008 0.257515678803134 1215 682556 SGTC_537 1334-0398 209 µM 0.649605934292802 0.298147377267872 no 1009 0.25797339943522 1258 5846986 SGTC_1963 st076565 50.3 µM 0.648659530489009 0.298452913191255 no 1010 0.258279233941025 1280 4914280 SGTC_167 3672-0051 66.205 µM 0.64823285947563 0.298590705752689 no 1011 0.258417175965489 1227 3237971 SGTC_1273 0849-0096 14.1 µM 0.644872087091695 0.299677070542099 no 1012 0.259505040863701 1270 5286025 SGTC_2322 7413319 38.22 µM 0.644767472593132 0.299710915744687 no 1013 0.259538941959689 1301 1840400 SGTC_2953 9074162 66.49 µM 0.644586502766519 0.299769467744232 no 1014 0.25959759195941 1247 16451992 SGTC_1887 st057648 70.8 µM 0.644341021735414 0.299848900341076 no 1015 0.25967716014805 1274 688672 SGTC_3170 9103054 49.47 µM 0.644149309762078 0.299910941006068 no 1016 0.259739308832844 1227 16432970 SGTC_1495 4469-0029 237 µM 0.641844814896662 0.300657161863895 no 1017 0.260486974201681 1285 793680 SGTC_2156 5649887 115 µM 0.640627663732791 0.301051626750176 no 1018 0.260882310886576 1325 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2450 5739737 12.93 µM 0.639645347252647 0.301370154375146 no 1019 0.26120159699993 1277 2262825 SGTC_1439 4092-1168 46 µM 0.638418869153401 0.301768067098099 no 1020 0.261600525586281 1286 2886240 SGTC_1571 st070080 73.4 µM 0.63620982254294 0.302485354770906 no 1021 0.262319835904655 1347 4315245 SGTC_493 zm226600 134 µM 0.635580921096158 0.302689701687273 no 1022 0.262524804045607 1312 5240098 A potassium channel opener. YCR052W RSC6 SGTC_55 0767-0285 6.563 µM 0.635241232031518 0.302800101475788 no 1023 0.262635547746361 1251 3116166 SGTC_400 oxethazaine 37.5 µM 0.635109051368594 0.302843065391986 no 1024 0.262678647073329 1266 4621 A local anesthetic. SGTC_477 mead ethanolamide 10 µM 0.635064317455278 0.302857606292062 no 1025 0.262693234001829 1177 16061185 SGTC_948 3448-0295 75.3 µM 0.634420708387387 0.303066848047649 no 1026 0.262903149263196 1312 678569 SGTC_825 1988-2224 89.6 µM 0.633569906035261 0.30334354897954 no 1027 0.263180772872211 1290 1180859 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.633128106551009 0.303487277081928 no 1028 0.263324994630575 1298 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_117 lucigenin 22.078 µM 0.631140633101723 0.304134226320819 no 1029 0.263974287530709 1263 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_264 promethazine 12.5 mM 0.630158894497908 0.304454021970681 no 1030 0.264295315087349 1323 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1712 st032288 53.4 µM 0.629672825031168 0.304612411648001 no 1031 0.26445433286658 1279 2883011 SGTC_1994 st072947 40.9 µM 0.629099694997735 0.30479921778729 no 1032 0.264641895071843 1312 5286565 YDL195W SEC31 SGTC_1363 1636-0063 10.4 µM 0.62543911917853 0.305993545864773 no 1033 0.265841447050916 1326 6072185 SGTC_1310 1188-0297 994 nM 0.624979369218721 0.306143693740455 no 1034 0.265992299309515 1251 1588352 SGTC_1788 fluconazole 20 µM 0.62402364656455 0.306455923537143 no 1035 0.266306027864405 1282 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_11 0438-0307 1.3 µM 0.622103451934085 0.307083666240698 no 1036 0.266936922652022 1322 4011476 SGTC_1777 st045864 34.765 µM 0.621826734057951 0.307174176484446 no 1037 0.267027902648719 1307 4691462 SGTC_1674 st016616 23.6 µM 0.617501689836789 0.308590357262071 no 1038 0.268451933508224 1282 625830 SGTC_1477 0139-0234 16 µM 0.616908526128718 0.308784804035775 no 1039 0.268647531367576 1323 620880 SGTC_966 1300-0360 30.2 µM 0.61555642689722 0.309228240075077 no 1040 0.269093658444369 1325 70588 SGTC_2430 5571206 200 µM 0.614585114615571 0.309546964440983 no 1041 0.269414373624746 1346 1731771 SGTC_119 0121-0043 24.815 µM 0.61386990334675 0.309781743979501 no 1042 0.269650649885552 1359 1092378 SGTC_1914 st062367 72.6 µM 0.613010611029951 0.310063923068612 no 1043 0.269934661784811 1324 978205 SGTC_322 k048-0136 19.3 µM 0.611487129720547 0.310564487150762 no 1044 0.270438568114424 1319 6823282 SGTC_2546 rhodinyl acetate 100 µM 0.610865417573042 0.310768861481593 no 1045 0.270644340459814 1326 6708682 SGTC_321 4534-3890 65.3 µM 0.60943812871965 0.311238272467431 no 1046 0.271117035685383 1349 699746 SGTC_1220 1838-0075 193 µM 0.607574925020923 0.311851510547336 no 1047 0.271734717821819 1261 5529645 SGTC_920 mycophenolic acid 780.421 nM 0.605660131553722 0.312482272347853 no 1048 0.272370231747412 1332 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_653 0203-0016 55.2 µM 0.605101046827599 0.312666547053842 no 1049 0.272555929368662 1365 295302 SGTC_684 1140-0066 328 µM 0.604887959159786 0.312736793224028 no 1050 0.272626722073634 1307 6813534 SGTC_1283 0922-0125 16.4 µM 0.60341856213737 0.31322137756383 no 1051 0.273115138431911 1349 3360884 SGTC_1670 st016595 4.04 µM 0.602908654488056 0.313389612662499 no 1052 0.273284729137559 1327 597879 SGTC_2100 5377183 190 µM 0.602883101828006 0.313398044337271 no 1053 0.273293229095111 1361 2844202 SGTC_1905 st060207 84.5 µM 0.601581299699779 0.313827732188085 no 1054 0.273726439895277 1307 1948547 SGTC_3044 9093193 49.47 µM 0.600804226990466 0.314084342228587 no 1055 0.273985194206028 1301 25236277 SGTC_2556 citropten 84.59 µM 0.599892057248206 0.314385679613156 no 1056 0.274289088095414 1320 2775 A potential DNA crosslinker. SGTC_3190 9110366 49.47 µM 0.599824145021553 0.314408119525366 no 1057 0.274311720046728 1295 17123768 SGTC_2811 7967822 32.47 µM 0.598003379995022 0.315010001649188 no 1058 0.274918838894205 1393 2232244 SGTC_3273 9137859 49.47 µM 0.597958196971171 0.315024943855337 no 1059 0.274933913210572 1398 2377234 SGTC_179 1273-0063 6.77 µM 0.597548352789091 0.315160494784739 no 1060 0.275070667255141 1307 3108139 SGTC_2984 9022109 38.96 µM 0.596488188413642 0.315511246569134 no 1061 0.275424571108373 1365 6459207 SGTC_2838 9002687 71.43 µM 0.596109124345344 0.315636699003175 no 1062 0.275551164543809 1328 6457060 SGTC_412 gemfibrozil 100 µM 0.594470316520278 0.316179311908895 no 1063 0.276098795043812 1329 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_366 0181-0206 4.31 µM 0.59390418400835 0.316366851758188 no 1064 0.276288100216802 1396 274874 SGTC_1587 estradiol valerate 56.1 µM 0.592012983222518 0.316993682513165 no 1065 0.276920947207429 1347 13791 A steroid. SGTC_1883 5-benzylidenerhodanine 20 µM 0.59189550657395 0.317032637022946 no 1066 0.276960281476704 1362 1273210 SGTC_2348 9022543 33.42 µM 0.590850029259596 0.317379399940964 no 1067 0.277310455199478 1376 3162678 YDL140C RPO21 SGTC_2268 7933382 153.85 µM 0.590848525393986 0.317379898857234 no 1068 0.277310959062363 1349 935025 YOR257W CDC31 SGTC_2950 9072895 21.46 µM 0.588922197770828 0.318019241534365 no 1069 0.277956733115368 1304 17332245 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.587891719009643 0.31836147746723 no 1070 0.278302487569658 1349 16623 A steroid. SGTC_1745 st081495 74 µM 0.587601008922344 0.318458054276958 no 1071 0.278400066840048 1321 13842402 YBL026W LSM2 SGTC_634 1611-4317 11.2 µM 0.587543123317099 0.318477285929253 no 1072 0.278419498617517 1380 2843522 SGTC_370 0180-0345 38.7 µM 0.587257752898708 0.318572103257908 no 1073 0.278515305054753 1325 3989527 SGTC_772 k072-0172 35.3 µM 0.585343266046121 0.319208518684905 no 1074 0.279158464154075 1276 5861980 SGTC_1960 st011366 51.8 µM 0.584799970583935 0.319389218644243 no 1075 0.279341112073227 1361 3972846 SGTC_2641 levomentholum 100 µM 0.582926329499539 0.320012720179934 no 1076 0.279971447563604 1323 16666 SGTC_1750 st081859 2.357 µM 0.581760940526001 0.320400789631705 no 1077 0.28036385848826 1368 5291695 SGTC_856 0433-0016 11.3 µM 0.578193267178975 0.321590029250992 no 1078 0.281566821938259 1367 3911780 SGTC_2911 7942208 15.64 µM 0.578082731082428 0.321626904385358 no 1079 0.281604132700861 1330 1243384 SGTC_2900 5328528 85.29 µM 0.577586445000044 0.321792488390628 no 1080 0.28177168031826 1340 795359 SGTC_604 1000-0114 314 µM 0.575804323585412 0.322387378165924 no 1081 0.28237372540352 1446 1572745 SGTC_2675 theaflavin digallate 100 µM 0.575715314849733 0.322417102108777 no 1082 0.282403810992945 1377 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2807 7945238 51.95 µM 0.574008058400111 0.32298744988084 no 1083 0.282981174089314 1415 17148797 SGTC_1981 st071826 47 µM 0.572696232410836 0.32342597819018 no 1084 0.283425194445179 1341 11838600 SGTC_2066 5222451 176 µM 0.572072744223002 0.323634489177468 no 1085 0.28363634666085 1344 2281147 SGTC_617 3770-0098 35 µM 0.571253791167387 0.32390845294013 no 1086 0.283913809986665 1390 5962639 SGTC_798 1287-0182 476 µM 0.570222980433945 0.324253424926825 no 1087 0.284263235765713 1429 1649755 SGTC_89 0302-0250 142.109 µM 0.564946393729242 0.326021650153559 no 1088 0.286055113212515 1434 4203518 YLR208W SEC13 SGTC_2472 5377652 49.4 µM 0.564056401781126 0.326320280742441 no 1089 0.286357873979546 1364 1610903 SGTC_1617 st002906 78 µM 0.563604250810197 0.326472039524001 no 1090 0.286511746623522 1386 5150859 SGTC_690 glyoxal 20.3 µM 0.563232723592829 0.326596759458618 no 1091 0.286638211345537 1296 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2967 9089538 49.85 µM 0.562755364731834 0.326757035027633 no 1092 0.286800739110842 1457 728216 SGTC_399 oxolinic acid 75 µM 0.562427679526428 0.326867075445255 no 1093 0.286912332327033 1361 4628 A DNA gyrase inhibitor. SGTC_2649 anisomycin 9.56 µM 0.56186116503104 0.327057352970688 no 1094 0.287105307385471 1359 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_193 1273-0060 1.558 µM 0.559937451672081 0.32770381373717 no 1095 0.287761051066436 1310 2847393 YHR072W ERG7 SGTC_2830 7992007 71.43 µM 0.559818222015281 0.32774389769712 no 1096 0.287801716620339 1409 1952075 SGTC_646 4092-0839 27.3 µM 0.558742885938297 0.328105505846259 no 1097 0.288168603138754 1468 877796 SGTC_2732 terfenadine 20 µM 0.558600236661848 0.328153487281469 no 1098 0.288217289236152 1397 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2587 piperic acid 92.2 µM 0.558570574130923 0.328163464910832 no 1099 0.288227413524293 1367 5370536 SGTC_82 0054-0107 293.755 µM 0.558204220182594 0.32828670603597 no 1100 0.288352469714546 1423 3104697 SGTC_2750 bromebric acid 70.15 µM 0.55781236334521 0.328418546996062 no 1101 0.288486259713395 1449 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1431 4049-0260 9.09 µM 0.555934312274151 0.329050717146667 no 1102 0.289127880376751 1407 3854841 SGTC_723 4182-0001 115 µM 0.555300749670952 0.32926409089646 no 1103 0.289344483087806 1354 744821 YLR208W SEC13 SGTC_86 0417-1630 471.922 µM 0.55516576036508 0.329309560325678 no 1104 0.289390643153347 1424 3634867 SGTC_357 1325-0123 420 µM 0.554028805093913 0.329692629355601 no 1105 0.289779566203731 1411 1098503 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.553013015422365 0.330035025823803 no 1106 0.290127248919795 1378 688803 SGTC_682 0kpi-0099 17 µM 0.550406386943244 0.330914304080823 no 1107 0.291020334461333 1397 1714895 YML126C ERG13 SGTC_1146 3579-1023 7 µM 0.550145769070997 0.331002268148998 no 1108 0.291109698185268 1518 X1146 SGTC_3321 9137793 26.8275 µM 0.549901960889472 0.331084567036075 no 1109 0.291193309605288 1398 4904192 SGTC_2760 etidronate 98.04 µM 0.549483996119872 0.331225672491737 no 1110 0.291336672253587 1382 3305 A chelator and antioxidant. SGTC_2195 6536160 144.242 µM 0.549069994288684 0.331365463683212 no 1111 0.291478708069432 1311 3834386 SGTC_2896 9052656 71.43 µM 0.545397390646208 0.33260657605532 no 1112 0.29274011734159 1372 6469436 SGTC_207 4185-0010 4.486 µM 0.545114748382561 0.332702167919106 no 1113 0.292837299912692 1467 3761753 SGTC_495 decylubiquinone 155 µM 0.544322059641 0.332970319579268 no 1114 0.293109934670421 1369 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1784 st039334 36.3 µM 0.539608276702519 0.334566664176678 no 1115 0.294733603743866 1504 3496984 SGTC_2880 9042983 58.44 µM 0.539285463804287 0.334676096180792 no 1116 0.294844948677561 1417 6464714 SGTC_1494 4358-1428 177 µM 0.538652186655619 0.334890814849883 no 1117 0.29506343554677 1521 1564571 SGTC_1534 6-azauridine 81.6 µM 0.538439426530323 0.334962965322538 no 1118 0.295136856622621 1421 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_874 0599-0792 117 µM 0.53648812360786 0.335624968201814 no 1119 0.295810620886596 1491 765305 SGTC_552 k242-0005 476 µM 0.535271675817514 0.336037921159797 no 1120 0.296231004656847 1431 4088318 SGTC_2193 5925765 200 µM 0.535032594695903 0.336119106389662 no 1121 0.29631365925663 1450 877370 SGTC_1407 3909-7909 12.3 µM 0.533881231416748 0.33651018400104 no 1122 0.296711854047865 1406 4411780 SGTC_2184 6075246 200 µM 0.531945902049629 0.337167945784976 no 1123 0.297381732128614 1461 2267320 SGTC_1133 3473-0247 50 µM 0.531164444032075 0.337433681764982 no 1124 0.297652414866356 1384 711311 SGTC_303 1348-1668 34.2 µM 0.530324635672236 0.337719350277589 no 1125 0.297943434369242 1448 5380509 SGTC_1295 1013-0063 9.78 µM 0.529644528757565 0.337950763423779 no 1126 0.298179207406915 1497 6826038 SGTC_1638 st008370 60.6 µM 0.528943957783907 0.338189203721133 no 1127 0.298422163546936 1404 24207134 SGTC_233 rapamycin 362 pM 0.528799469370482 0.338238388629872 no 1128 0.298472282946094 1467 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2308 7584454 197.62 µM 0.526670375962179 0.338963467200726 no 1129 0.299211255510094 1533 893577 SGTC_462 ag-879 158 µM 0.526445457285918 0.339040099836185 no 1130 0.29928936946677 1516 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1262 0737-0114 49.6 µM 0.526344130480524 0.339074625335658 no 1131 0.299324563153673 1459 765919 SGTC_2701 st077767 14.721 µM 0.525269108080079 0.339441005325943 no 1132 0.29969806461216 1415 5721188 SGTC_1911 st060208 74.3 µM 0.523806519717814 0.339939715984676 no 1133 0.300206559132348 1528 688783 SGTC_999 SEC7.066 22.7 µM 0.521688717858069 0.340662336629622 no 1134 0.300943540614326 1507 740511 YDR170C SEC7 SGTC_866 0495-0101 262 µM 0.521163279272633 0.340841713596515 no 1135 0.301126516109385 1393 635694 SGTC_2888 9058547 12.99 µM 0.519645307935092 0.341360128633447 no 1136 0.301655406473109 1384 16476514 SGTC_2499 avocadenofuran 51.48 µM 0.519414224890895 0.341439074019864 no 1137 0.301735956868696 1387 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3182 9108849 49.47 µM 0.517790911593272 0.341993845350982 no 1138 0.302302080033187 1456 17133045 SGTC_3249 9135183 49.47 µM 0.517577767082262 0.342066713388654 no 1139 0.302376448596685 1480 4902779 SGTC_2419 paclitaxel 166.5 µM 0.515080617190215 0.342920855338441 no 1140 0.303248343311079 1403 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2404 5161160 200 µM 0.51404673266146 0.343274727595733 no 1141 0.303609658949434 1494 2831543 SGTC_470 aa-861 153 µM 0.514003715127409 0.343289454379251 no 1142 0.303624696618174 1422 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2214 7179297 48.276 µM 0.513978499100765 0.343298087038765 no 1143 0.3036335115564 1507 769744 SGTC_257 daunorubicin 18.5 µM 0.51360375827009 0.343426388494819 no 1144 0.303764525724314 1581 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1967 st070177 51.4 µM 0.513493328302907 0.343464200269198 no 1145 0.30380313825883 1522 5729214 SGTC_66 0109-0187 42.4 µM 0.512530071379549 0.343794090665206 no 1146 0.304140039928776 1423 759417 SGTC_1591 genipin 88.4 µM 0.512321086311957 0.343865678319574 no 1147 0.304213154982658 1498 442424 A DNA cross-linking agent. SGTC_1572 epiandrosterone 68.9 µM 0.512145008558232 0.343925997947329 no 1148 0.304274763233167 1459 441302 A steroid. SGTC_3045 9092950 49.47 µM 0.511145118981293 0.344268609224972 no 1149 0.304624722214081 1581 44120432 SGTC_3231 9132313 49.47 µM 0.510800348583332 0.344386774152222 no 1150 0.30474543252834 1502 4905967 SGTC_614 0462-0418 107 µM 0.509837463796224 0.344716869018844 no 1151 0.305082668369268 1385 5188303 SGTC_463 ikarugamyin 104 µM 0.509505248672306 0.344830786012522 no 1152 0.305199060129033 1503 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_467 ro 31-8220 72.8 µM 0.509276804392029 0.344909128014269 no 1153 0.305279107147017 1470 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1718 roemerine 11.9335 µM 0.508696910947198 0.345108024803224 no 1154 0.305482343990705 1424 235224 An aporphine alkaloid with mutagenic activity. SGTC_1400 3771-8998 51.5 µM 0.506906931089066 0.345722237060032 no 1155 0.306110061110346 1502 670767 SGTC_3116 9124943 49.47 µM 0.506488097392042 0.345866014036752 no 1156 0.306257021664628 1385 41905195 YPL160W CDC60 SGTC_897 1000-0139 31.4 µM 0.504855718701221 0.346426587980622 no 1157 0.306830088811384 1565 6151020 SGTC_1950 st077106 7.18 µM 0.504205358524636 0.346650021502284 no 1158 0.307058537641883 1446 13831864 SGTC_2671 danthron 100 µM 0.501586296565125 0.347550348806411 no 1159 0.307979280361713 1461 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1926 methyl fluorone black 53.6 µM 0.500884377783 0.347791786467722 no 1160 0.308226248842951 1380 72721 Reacts with homocysteine. SGTC_1052 3253-3998 198 µM 0.50081152621735 0.347816848619368 no 1161 0.308251886471947 1433 5450317 SGTC_1426 4048-4480 71.7 µM 0.49899952135761 0.348440422169606 no 1162 0.308889860622658 1549 14224343 SGTC_231 b-estradiol 524 µM 0.498518849243349 0.348605906916909 no 1163 0.309059193498913 1419 450 A steroid. SGTC_2835 9006588 71.43 µM 0.496739169551797 0.349218861776693 no 1164 0.3096864984141 1472 2345538 SGTC_944 3370-0224 231 µM 0.494248740372035 0.35007727240226 no 1165 0.310565260747395 1476 4580514 SGTC_2147 5545932 89.7195 µM 0.494093488418001 0.350130810668071 no 1166 0.310620078178432 1483 797404 SGTC_1865 st057639 52.2 µM 0.493050225898739 0.35049065447536 no 1167 0.310988549529196 1487 688818 SGTC_2873 9040596 71.43 µM 0.491969301227403 0.350863630348171 no 1168 0.311370522797268 1475 6463863 SGTC_1187 1391-0724 117 µM 0.491562609777482 0.351003997530825 no 1169 0.311514290579384 1514 6997986 SGTC_60 0986-0278 202 µM 0.490737190937498 0.351288948529001 no 1170 0.311806169270709 1317 3110598 SGTC_1080 nisoldipine 24.4 µM 0.489369842418099 0.351761168351238 no 1171 0.312289941376119 1485 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1827 berberine 7.24 µM 0.488824954144673 0.351949411706381 no 1172 0.312482814791649 1375 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_981 1488-1094 54.9 µM 0.488384857267955 0.352101479120384 no 1173 0.312638632838589 1456 3449522 SGTC_1139 k015-0024 46.9 µM 0.488330472416291 0.352120272452258 no 1174 0.31265789033705 1510 2766652 SGTC_3337 9144342 33.5465 µM 0.487681741263601 0.352344477051249 no 1175 0.312887643345502 1565 17682949 SGTC_3275 9138069 49.47 µM 0.486954776929141 0.352595780389234 no 1176 0.313145189597915 1535 17617007 SGTC_1300 1094-0077 113 µM 0.484789684013578 0.353344609317663 no 1177 0.313912770560072 1457 5532636 SGTC_1581 himbacine 57.9 µM 0.483757416440526 0.353701834278886 no 1178 0.314279019836876 1485 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1450 4112-4260 37.6 µM 0.483596900493723 0.353757393770402 no 1179 0.31433598745275 1574 1633175 SGTC_1390 3413-2614 145 µM 0.481954244722412 0.354326146167339 no 1180 0.314919225161885 1502 3421432 SGTC_40 0327-0103 19.753 µM 0.479994514070645 0.355005107589888 no 1181 0.315615646945125 1475 409036 SGTC_34 0469-0683 81.75 µM 0.476547942031471 0.356200311373359 no 1182 0.316842030361788 1575 3690923 SGTC_304 1310-0298 97 µM 0.476545112400535 0.356201293216601 no 1183 0.316843038050659 1454 1550234 SGTC_593 1203-0218 61.7 µM 0.474718303448858 0.356835369674194 no 1184 0.317493885043082 1608 3666956 SGTC_739 1486-1183 203 µM 0.473389173724849 0.357296952934391 no 1185 0.317967776167687 1591 4346692 SGTC_1608 st001473 40.5 µM 0.47270484075793 0.357534691184983 no 1186 0.318211886256949 1461 7292267 SGTC_3330 9141424 71.43 µM 0.472411934901014 0.357636464001715 no 1187 0.318316393564638 1611 27261020 SGTC_1059 3448-6867 171 µM 0.471687938512872 0.35788806658596 no 1188 0.318574773800419 1544 3934407 SGTC_150 3970-0969 77.2 µM 0.471162739831256 0.358070621818261 no 1189 0.318762262235666 1559 6615640 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.469886987050757 0.35851419928585 no 1190 0.319217880942214 1569 5393153 SGTC_1405 3909-7894 12 µM 0.46983058268845 0.358533815416497 no 1191 0.31923803134604 1610 7104060 SGTC_589 1227-0070 34.1 µM 0.467172731140111 0.359458576984822 no 1192 0.320188150804675 1531 2841384 SGTC_2255 7941087 197.44 µM 0.466989685670158 0.359522295427088 no 1193 0.320253628766789 1639 935561 SGTC_2153 5569715 200 µM 0.466975872275731 0.359527104051921 no 1194 0.320258570241153 1550 2054701 SGTC_3053 9095903 49.47 µM 0.466402522914273 0.359726714142509 no 1195 0.320463702982691 1581 17174018 SGTC_1539 benzyladenosine 56 µM 0.466293689129108 0.359764608665453 no 1196 0.32050264769472 1498 92208 A nucleotide analog. SGTC_1995 st072814 61.1 µM 0.465726609055167 0.359962080946138 no 1197 0.320705601672808 1479 5769371 SGTC_3301 9125354 19.7965 µM 0.465547531971602 0.360024448091718 no 1198 0.320769703243835 1499 41905162 SGTC_2459 5811157 9.22 µM 0.465277543893195 0.360118483837664 no 1199 0.320866356979188 1499 2870684 YBR192W RIM2 SGTC_403 arphamenine a 50 µM 0.463350648800159 0.360789859020154 no 1200 0.321556523416348 1580 5487158 An arginine aminopeptidase inhibitor. SGTC_265 mycophenolic acid 32.932 µM 0.462365480394405 0.361133280632837 no 1201 0.321909624805789 1592 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1359 1582-0056 520 nM 0.461680756233781 0.361372035817077 no 1202 0.322155136564345 1583 3661189 SGTC_2199 6590217 200 µM 0.461541308033198 0.361420666370255 no 1203 0.322205146030168 1569 703109 SGTC_1806 st050005 60.3 µM 0.461105692101469 0.361572595576248 no 1204 0.322361389069496 1496 5194765 SGTC_2005 4024620 188 µM 0.460942270347675 0.361629597601788 no 1205 0.32242001189978 1514 236743 SGTC_1884 5633444 25 µM 0.460790776246882 0.361682441967008 no 1206 0.322474359973751 1560 5724239 SGTC_1341 1486-1360 280 µM 0.460086688306465 0.361928077425925 no 1207 0.322726999279155 1507 3976547 SGTC_735 3076-0345 636 µM 0.453135618539632 0.36435613860875 no 1208 0.325225544302072 1642 2888990 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.452024942078523 0.364744614109155 no 1209 0.325625507086547 1577 7104 SGTC_285 1486-1325 46 µM 0.451946818952131 0.364771944060419 no 1210 0.325653647365765 1598 22310230 SGTC_752 1896-0090 130 µM 0.45118176679931 0.365039619902005 no 1211 0.325929274860459 1551 772567 SGTC_859 0439-0102 54.6 µM 0.450963307360135 0.365116066396746 no 1212 0.326007997329145 1612 610143 SGTC_817 1391-0715 46 µM 0.450701187922818 0.365207798106021 no 1213 0.326102463035627 1528 1353946 SGTC_1355 1499-0035 1.68 µM 0.450211570467965 0.365379166016766 no 1214 0.326278947061246 1521 1548538 SGTC_1286 0929-0070 131 µM 0.447965093669264 0.366165785289276 no 1215 0.327089194381436 1622 1420408 SGTC_192 3455-0609 60.9 µM 0.445792724167392 0.366926990717718 no 1216 0.327873488982919 1570 3769639 SGTC_251 melphalan 456.522 µM 0.445623433382781 0.366986332792441 no 1217 0.327934640304587 1649 460612 A DNA alkylator. SGTC_2090 5301565 104.445 µM 0.445558986287326 0.367008924487443 no 1218 0.327957921136685 1567 2056344 SGTC_1863 st057641 20.1 µM 0.445466792950741 0.367041243327021 no 1219 0.327991226167321 1570 3921635 SGTC_2822 7994718 71.43 µM 0.444806927022026 0.36727259015424 no 1220 0.328229643995795 1589 1018011 SGTC_235 0330-0087 5 mM 0.444349517565354 0.367432984693868 no 1221 0.328394952841784 1541 46494818 YHR062C RPP1 SGTC_3040 9091894 49.47 µM 0.443018219710757 0.367899947219897 no 1222 0.328876278120062 1600 25236966 SGTC_2842 9000675 19.48 µM 0.442737237561903 0.367998528760483 no 1223 0.328977902377708 1481 2989072 SGTC_151 3013-0144 2.285 µM 0.442584010123545 0.368052291700438 no 1224 0.329033326260316 1628 906558 YHR107C CDC12 SGTC_3335 9143315 29.6265 µM 0.441349660571517 0.36848548234759 no 1225 0.329479939732803 1546 4899691 SGTC_1027 k015-0025 8.67 µM 0.439784079013091 0.369035158185333 no 1226 0.330046749895658 1519 3598955 SGTC_822 1487-0950 154 µM 0.439560203939313 0.369113782668713 no 1227 0.33012783456093 1608 1958375 SGTC_1096 rimcazole 32.2 µM 0.43912750490623 0.369265761232357 no 1228 0.3302845751848 1560 18528119 A dopamine reuptake inhibitor. SGTC_1211 1056-0033 32.3 µM 0.438918493485357 0.369339180447469 no 1229 0.330360298019649 1614 6741922 SGTC_3163 9099914 49.47 µM 0.43838692589722 0.369525925085015 no 1230 0.330552911157853 1618 16268368 SGTC_2629 bisabolol 100 µM 0.437675110736935 0.369776040576892 no 1231 0.3308109071717 1649 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2406 ethylparaben 405.7 µM 0.437328298251436 0.369897922486239 no 1232 0.330936637811377 1391 8434 A possible steroid mimic. SGTC_1031 k035-0009 16 µM 0.436630719041832 0.370143115532348 no 1233 0.331189590374676 1694 5180959 SGTC_1862 st057513 3.81 µM 0.434821814834512 0.370779175362911 no 1234 0.331845884596385 1558 5393163 SGTC_2907 7721985 69.9 µM 0.433792942871923 0.371141112419655 no 1235 0.332219403374903 1526 3267881 SGTC_1505 k297-0037 20.6 µM 0.432563657603295 0.371573700423621 no 1236 0.332665898236828 1556 4089396 SGTC_2110 5483698 200 µM 0.431971750154449 0.371782051768543 no 1237 0.332880972645967 1589 2848765 YHR062C RPP1 SGTC_2017 5132927 60.65 µM 0.431069239970747 0.372099807512975 no 1238 0.333209012938645 1525 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1147 3809-1045 12.3 µM 0.429868046219587 0.372522858862483 no 1239 0.333645815341476 1550 325925 SGTC_1333 1482-0047 286 µM 0.429282195438168 0.372729246923032 no 1240 0.333858936149948 1650 3811116 SGTC_749 1000-0129 128 µM 0.428613229149034 0.372964960244944 no 1241 0.334102358268714 1723 708470 SGTC_898 1000-0849 28.3 µM 0.428540985912254 0.372990418326032 no 1242 0.334128650171478 1605 6751807 SGTC_2593 nobiletin 86.24 µM 0.427413030914868 0.373387974734456 no 1243 0.33453925891504 1543 72344 An anti-infammatory. SGTC_1342 1486-1464 234 µM 0.425968520557787 0.373897300333748 no 1244 0.335065392201276 1578 3253938 SGTC_685 1278-0033 54.9 µM 0.422260990652834 0.375205559167928 no 1245 0.336417264061491 1672 3590572 SGTC_1259 0671-0132 43 µM 0.421183535058684 0.375586026039328 no 1246 0.336810533197815 1577 X1259 SGTC_460 trequinsin 123 µM 0.420726463645516 0.375747461875304 no 1247 0.336977417295848 1611 5537 A vasodilator. SGTC_1669 st015249 58.4 µM 0.41913111129312 0.376311104389748 no 1248 0.337560157336546 1674 722793 SGTC_2789 5281112 71.43 µM 0.417926730562792 0.37673679039379 no 1249 0.338000344049798 1545 765948 SGTC_2690 usnic acid 100 µM 0.417871682357775 0.37675625066016 no 1250 0.338020468808827 1737 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2124 5246320 200 µM 0.417156984369047 0.377008934232169 no 1251 0.338281793170305 1632 579342 SGTC_942 3253-1115 227 µM 0.416463035394462 0.377254332342245 no 1252 0.338535605362367 1689 46497897 SGTC_2426 5582046 32.21 µM 0.416419539455966 0.377269715270878 no 1253 0.338551516468425 1633 2251934 SGTC_1804 st050076 49.1 µM 0.414577079337982 0.377921504838846 no 1254 0.339225765081781 1637 3895976 SGTC_1795 st049545 62.3 µM 0.413705490993026 0.378229959600708 no 1255 0.339544902621706 1714 5291882 SGTC_12 0849-0099 9.267 µM 0.413364006449805 0.37835083201736 no 1256 0.339669970721227 1666 6071388 SGTC_2128 5255449 168.493 µM 0.411427006533418 0.379036680576016 no 1257 0.340379727204859 1571 736008 SGTC_2391 6285546 200 µM 0.410989428036357 0.37919167021536 no 1258 0.340540143370354 1572 846083 SGTC_1153 4055-0057 267 µM 0.410116941135638 0.379500761697391 no 1259 0.340860082936511 1578 882706 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.408563502101387 0.380051281166286 no 1260 0.341430009865876 1632 368090 SGTC_1473 k844-0725 134 µM 0.407720730580574 0.380350050713493 no 1261 0.341739358014976 1663 54682906 SGTC_2451 5856223 45.7 µM 0.407636945227393 0.380379757226012 no 1262 0.341770118123056 1568 2179896 SGTC_3140 9094243 49.47 µM 0.407399350984504 0.380464001279635 no 1263 0.341857351786165 1615 19291112 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.407112119188547 0.380565852945007 no 1264 0.341962821346984 1529 641818 YHR062C RPP1 SGTC_2603 homopterocarpin 100 µM 0.406085902365351 0.380929814409964 no 1265 0.342339741882627 1605 101795 A weak amylase inhibitor. SGTC_2364 9055074 200 µM 0.405823635709933 0.38102284769212 no 1266 0.342436095369331 1559 6470630 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.405758129146282 0.381046085767135 no 1267 0.342460163261873 1567 6708760 SGTC_606 k015-0008 38.6 µM 0.404860253380269 0.381364645213559 no 1268 0.342790117965069 1734 1970475 SGTC_1009 4106-0057 9.87 µM 0.404505278464204 0.381490609782061 no 1269 0.342920598560265 1658 2928005 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.400723650196169 0.382833315613682 no 1270 0.344311798220311 1567 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3289 9119912 71.43 µM 0.4000662748912 0.383066867683878 no 1271 0.344553851649725 1638 17014829 SGTC_1389 3405-0187 19 µM 0.398816937432407 0.383510848975361 no 1272 0.34501404801093 1589 799890 SGTC_2132 5317594 122.667 µM 0.396179814507481 0.384448513991766 no 1273 0.3459861906523 1678 794577 SGTC_1605 st000082 49.1 µM 0.39609352538456 0.384479206725683 no 1274 0.346018017267256 1680 1114022 SGTC_2343 7990716 14.84 µM 0.39529884667957 0.384761905136274 no 1275 0.346311175233326 1676 6456862 SGTC_478 N-arachidonylglycine 10 µM 0.395192437812975 0.384799763602626 no 1276 0.346350436592719 1664 5283389 SGTC_833 3852-0053 558 µM 0.393824054317715 0.385286708963057 no 1277 0.346855471936494 1690 3123681 SGTC_2259 7964009 200 µM 0.393211962094144 0.385504583315545 no 1278 0.347081467689137 1685 313134 SGTC_1667 st014849 34.6 µM 0.392600196791104 0.385722377408049 no 1279 0.347307397092771 1646 5348460 SGTC_1203 3992-3522 103 µM 0.390665471000795 0.386411394505873 no 1280 0.348022262355676 1860 5322312 SGTC_1081 sertraline 6 µM 0.390559190576622 0.386449254730992 no 1281 0.348061547780555 1737 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1303 1160-0052 261 µM 0.389448307794748 0.38684504861426 no 1282 0.348472271280354 1655 3562476 SGTC_1067 clotrimazole 1.36 µM 0.389293961438458 0.386900049646826 no 1283 0.348529351387492 1629 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3201 9113999 49.47 µM 0.389234100653968 0.386921381535662 no 1284 0.348551489924179 1724 16649224 SGTC_318 1488-0629 67.2 µM 0.38913874725641 0.386955362218008 no 1285 0.34858675589128 1605 3662576 SGTC_3101 9120531 49.47 µM 0.388883668753259 0.387046267711537 no 1286 0.34868110180469 1729 24824904 SGTC_2031 5180455 200 µM 0.388651683044377 0.387128948719319 no 1287 0.348766914510518 1621 29949 SGTC_1888 azatryptophan 97.5 µM 0.385936995153359 0.38809685838446 no 1288 0.349771665503617 1622 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3160 9100216 49.47 µM 0.384160436284598 0.3887306593248 no 1289 0.350429769949094 1649 17191039 SGTC_1082 camptothecin 424.86 nM 0.383580136152699 0.388937750108397 no 1290 0.350644832451555 1453 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2470 5664817 21.68 µM 0.383517907158344 0.388959959545128 no 1291 0.350667897711313 1660 2859561 SGTC_596 1155-0152 116 µM 0.382703323388997 0.389250716734295 no 1292 0.350969875009132 1634 280313 SGTC_1501 4491-0275 38.4 µM 0.382684384947714 0.389257477351935 no 1293 0.35097689686787 1757 5104718 SGTC_2140 5586273 200 µM 0.382593778060121 0.389289822532694 no 1294 0.351010492140627 1649 854421 SGTC_1893 st059353 36.1 µM 0.382587736725063 0.389291979218036 no 1295 0.351012732191656 1607 3112488 SGTC_2108 5365811 200 µM 0.381230926836121 0.389776430612506 no 1296 0.351515951253476 1706 780283 SGTC_389 tpck 16.7 µM 0.381175517275854 0.389796218340483 no 1297 0.351536507310954 1654 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_741 4582-0002 126 µM 0.379332099401455 0.390454697798165 no 1298 0.352220632916253 1617 2912688 SGTC_1056 3448-1962 115 µM 0.378851739123021 0.390626336954337 no 1299 0.352398981954514 1687 715507 SGTC_851 0394-0702 453 µM 0.375585921877398 0.391793820595691 no 1300 0.353612379239425 1775 762646 SGTC_1530 rhein 70.4 µM 0.375279862261098 0.391903282729996 no 1301 0.353726170581966 1674 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1774 st048371 48.465 µM 0.373649780287961 0.392486425035782 no 1302 0.354332446385104 1620 4242727 SGTC_1168 k815-0004 80.5 µM 0.371693616395483 0.393186537917316 no 1303 0.355060489207778 1632 642433 SGTC_90 0870-0863 4.608 µM 0.37148019762925 0.393262941642024 no 1304 0.355139951239936 1642 1738164 SGTC_647 0140-0236 81 µM 0.369501770418645 0.393971412122504 no 1305 0.355876876894563 1709 990837 SGTC_2862 9027634 71.43 µM 0.369087632738744 0.394119758433953 no 1306 0.356031203419722 1606 5012562 SGTC_2511 berberine 10.47 µM 0.367672842139751 0.394626659683681 no 1307 0.356558596528587 1660 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2056 5235370 200 µM 0.36711152073592 0.394827823409954 no 1308 0.356767917035198 1639 5511916 SGTC_1338 1486-1223 76 µM 0.365895885012907 0.395263573285628 no 1309 0.357221383527132 1742 3444526 SGTC_1908 st060353 56.5 µM 0.365883783058874 0.395267911942768 no 1310 0.357225898913291 1858 4227716 SGTC_921 1561-0023 372 µM 0.364332440687366 0.395824189174454 no 1311 0.357804888964351 1627 24050882 SGTC_102 gallobenzophenone 83.616 µM 0.362128023271746 0.396615009592604 no 1312 0.358628181619217 1779 70837 SGTC_1925 st057770 10.1 µM 0.361789091144712 0.396736637107228 no 1313 0.358754822369003 1573 5989122 SGTC_2992 9074591 71.4286 µM 0.361695978543351 0.396770052796716 no 1314 0.358789616271778 1684 17741321 SGTC_3318 9139014 38.6185 µM 0.36127864101223 0.396919833685807 no 1315 0.358945579497117 1681 16643984 SGTC_344 k064-0035 6.43 µM 0.359812792127538 0.397446041778195 no 1316 0.359493568149361 1629 5088750 SGTC_3184 9108758 49.47 µM 0.359596308006919 0.397523770746723 no 1317 0.359574522464288 1679 902885 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.359070068555715 0.397712734822663 no 1318 0.359771336170234 1715 688788 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.358862726887615 0.397787194456289 no 1319 0.359848892230333 1631 4330530 SGTC_661 1304-0007 33.6 µM 0.35835064373372 0.397971107469449 no 1320 0.360040461430459 1662 3117130 SGTC_714 4296-0578 26.1 µM 0.358163236547132 0.39803841982549 no 1321 0.360110578843491 1795 1589775 SGTC_1474 0330-0125 5.35 µM 0.357995319975557 0.398098734178279 no 1322 0.360173407943325 1669 X1474 SGTC_2887 9044784 58.44 µM 0.357407113102598 0.398310032800216 no 1323 0.360393526233584 1683 6465546 SGTC_2817 7995342 71.43 µM 0.355667405485863 0.398935153598682 no 1324 0.361044828789461 1602 18879975 SGTC_1763 st044482 94.5 µM 0.353805665801838 0.399604410812444 no 1325 0.36174226355224 1760 88505 SGTC_237 nikkomycin 200 µM 0.352468768701082 0.400085180042184 no 1326 0.362243368254533 1783 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2278 7948257 134.34 µM 0.350800754101032 0.400685236654307 no 1327 0.362868915712073 1852 1247028 SGTC_1194 1488-0194 225 µM 0.350430154503165 0.400818589153064 no 1328 0.363007949654319 1707 1391452 SGTC_2680 butyl paraben 22.24 µM 0.349195941511074 0.40126277809493 no 1329 0.363471106436587 1716 7184 An antifungal and steroid mimetic. SGTC_457 grayanotoxin iii 135 µM 0.348998738873448 0.401333762476274 no 1330 0.363545128174554 1724 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_801 0866-0028 10.1 µM 0.348653736876249 0.401457956036249 no 1331 0.363674639948606 1714 6849771 SGTC_2051 5263410 176 µM 0.348317735429562 0.401578919153919 no 1332 0.36380078794271 1754 227584 SGTC_2173 5763948 167 µM 0.348031850111135 0.401681847504758 no 1333 0.363908132021683 1718 2867177 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.344300221530967 0.403025982637728 no 1334 0.365310258852837 1781 5377381 SGTC_793 0488-0545 106 µM 0.34399881511091 0.403134599696963 no 1335 0.365423588590817 1660 292548 SGTC_1348 1493-0373 93.8 µM 0.342278223964521 0.403754787595553 no 1336 0.366070760872449 1739 3010129 SGTC_687 k029-0044 34.9 µM 0.341376278025661 0.40407999124168 no 1337 0.3664101655334 1847 5829338 SGTC_1376 2910-0861 41.3 µM 0.340240451443632 0.404489616674957 no 1338 0.366837728761535 1750 1112859 SGTC_681 1642-0006 26.6 µM 0.339000575430277 0.404936886111779 no 1339 0.367304648337171 1685 4446530 SGTC_560 2332-1943 155 µM 0.338714211759305 0.405040205827526 no 1340 0.367412516727619 1715 21177716 SGTC_2627 acetyl isogambogic acid 100 µM 0.336583081701018 0.405809322813011 no 1341 0.36821560581953 1630 6857789 A caspase activator and apoptosis inducer. SGTC_3217 9129673 49.47 µM 0.335391950614136 0.406239356288362 no 1342 0.368664719587622 1729 17248312 SGTC_22 0964-0034 14.468 µM 0.33528358473417 0.406278485191232 no 1343 0.368705587656093 1716 138402 SGTC_6 0844-0013 19.835 µM 0.334351854116132 0.406614954363587 no 1344 0.369057032828926 1792 1584900 SGTC_1392 3455-1037 33.9 µM 0.331807452036683 0.407534146552345 no 1345 0.370017328436285 1806 981132 SGTC_1818 st052136 56.3 µM 0.329242442001814 0.408461299151857 no 1346 0.370986222734075 1675 674169 SGTC_2154 5570129 200 µM 0.329030366344298 0.408537979369985 no 1347 0.371066367867986 1750 673366 SGTC_3317 9138495 8.753 µM 0.328525444798837 0.408720557995176 no 1348 0.371257204372356 1735 17020139 SGTC_1762 st045503 25.4615 µM 0.328292774041832 0.408804697947793 no 1349 0.37134515359103 1711 4645554 SGTC_1681 tripelennamine 100 µM 0.327654641740291 0.409035485171667 no 1350 0.371586401170324 1694 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_154 3389-1638 511.116 µM 0.327135159732573 0.409223384566383 no 1351 0.371782829950221 1612 5238686 SGTC_2612 dictamnine 15.46 µM 0.326837286389011 0.409331136345225 no 1352 0.371895478167676 1738 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2773 thioridazine 9.09 µM 0.32663398553803 0.409404681697861 no 1353 0.371972367741305 1767 5452 An antipsychotic. SGTC_458 nppb 133 µM 0.324414417071632 0.41020783135324 no 1354 0.372812153115203 1907 4549 A chloride channel blocker. SGTC_523 1934-0222 13.7 µM 0.324352612918204 0.410230200560237 no 1355 0.372835545714524 1710 1361595 SGTC_3305 9127027 53.8275 µM 0.324117951428271 0.410315135884294 no 1356 0.372924368322591 1757 41905295 SGTC_2776 terbinafine 19.92 µM 0.321292904892532 0.411337985712273 no 1357 0.373994216351679 1751 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1977 st070720 65.3 µM 0.320595450180206 0.411590602566664 no 1358 0.374258492995854 1738 682188 SGTC_998 3996-0085 177 µM 0.319986751403974 0.411811102135968 no 1359 0.374489186909647 1855 715391 SGTC_2408 sulbentine 18.36 µM 0.319507864091645 0.411984597413861 no 1360 0.374670714490257 1803 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1046 2001-0062 216 µM 0.319412870503693 0.412019014526891 no 1361 0.374706726172675 1710 739778 SGTC_536 3852-0578 10.6 µM 0.31861868717145 0.412306781429974 no 1362 0.375007840567331 1857 2869208 SGTC_1989 st071868 50.2 µM 0.318133124494791 0.412482744984732 no 1363 0.375191979073582 1885 16414057 SGTC_2715 st079500 56.4 µM 0.317445698654157 0.412731892012079 no 1364 0.375452718188986 1696 28246688 SGTC_1463 k081-0032 34.1 µM 0.316281967632817 0.413153748695218 no 1365 0.375894248464508 1671 977755 SGTC_784 4579-0127 173 µM 0.314807404607166 0.413688427099146 no 1366 0.376453944661884 1888 1948547 SGTC_2336 9001819 198.65 µM 0.314445465393931 0.413819691216685 no 1367 0.37659136478748 1838 2989602 SGTC_2449 5812982 45.77 µM 0.312593812852426 0.414491378465387 no 1368 0.377294639678454 1755 776185 SGTC_2250 alverine citrate 130 µM 0.312450475192638 0.414543384679526 no 1369 0.377349097665522 1734 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3096 9117468 49.47 µM 0.310969994709134 0.415080624681652 no 1370 0.377911716129281 1829 41316311 SGTC_2002 4023503 131 µM 0.310955704529947 0.415085811108753 no 1371 0.377917148007935 1946 4736863 YCR052W RSC6 SGTC_2151 5563267 85.4165 µM 0.310823523368566 0.415133785173426 no 1372 0.377967392890712 1762 5310824 SGTC_712 r015-0009 80.6 µM 0.310443116925943 0.415271857619831 no 1373 0.378112005021542 1829 6813872 YLR060W FRS1 SGTC_1687 st020778 55.3625 µM 0.310234281611221 0.415347661003926 no 1374 0.378191401370519 1800 4259299 SGTC_160 3453-0671 289.699 µM 0.308874828900995 0.415841194267277 no 1375 0.378708372414215 1712 5322268 SGTC_428 3448-4153 16.5 µM 0.308148567741127 0.416104909269875 no 1376 0.378984643170916 1672 3834874 SGTC_1767 st044992 70.3 µM 0.306466794043502 0.416715728306364 no 1377 0.37962462938944 1710 9600693 SGTC_539 4859-0462 2.54 µM 0.303606911564128 0.41775489671808 no 1378 0.380713692668539 1913 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_525 k781-2675 26.7 µM 0.303147151679227 0.417922009110522 no 1379 0.380888860930866 1791 3651118 YDL195W SEC31 SGTC_144 4161-2749 112.381 µM 0.301481062654795 0.418527719009526 no 1380 0.381523844237221 1816 797501 YMR168C CEP3 SGTC_3025 9087895 49.47 µM 0.296773324933513 0.420240266037733 no 1381 0.383319786040127 1889 17173641 SGTC_2540 epiandrosterone 100 µM 0.295658044863265 0.420646197218802 no 1382 0.383745620376958 1798 441302 A steroid. SGTC_1697 st025554 27.742 µM 0.294242323461772 0.421161602269761 no 1383 0.384286370931056 1766 1269519 SGTC_2739 tacrine 100.86 µM 0.292723889707932 0.42171455077702 no 1384 0.384866604002164 1787 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2085 5307070 144.047 µM 0.290444229595195 0.422544994874969 no 1385 0.385738205458742 1748 2840351 SGTC_2804 7954240 19.48 µM 0.290189258128762 0.42263789842562 no 1386 0.385835726796318 1880 828705 SGTC_3132 9126706 49.47 µM 0.288463319016995 0.423266889039105 no 1387 0.38649605242912 1826 850858 SGTC_497 capsazepine 133 µM 0.287120972150988 0.423756220978364 no 1388 0.387009847243526 1703 2733484 A calcium channel blocker. SGTC_1816 st051957 91.6 µM 0.285728142425045 0.424264079973031 no 1389 0.387543174171741 1810 674121 SGTC_1935 st074532 41.6 µM 0.283620325975562 0.425032879155067 no 1390 0.388350679310963 1959 2829742 SGTC_1569 carminic acid 40.6 µM 0.283583419358009 0.425046342922431 no 1391 0.388364822558836 1940 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2480 5767542 37.17 µM 0.282754700622989 0.425348687748325 no 1392 0.388682440715961 1854 2867358 SGTC_287 k060-0039 29.6 µM 0.282217755369695 0.425544607119836 no 1393 0.388888272316502 1916 5861974 SGTC_1987 st072290 61.9 µM 0.28061662299786 0.42612893365032 no 1394 0.38950223241603 1809 54697379 SGTC_20 0481-0013 4.944 µM 0.280344049188512 0.426228424510448 no 1395 0.389606779370117 1766 182045 SGTC_2018 5133068 143 µM 0.279096881182829 0.426683707125419 no 1396 0.390085238264589 1802 785362 SGTC_1721 st082152 9.2685 µM 0.27909537465802 0.426684257146256 no 1397 0.390085816323028 1793 5296051 SGTC_2016 5121758 140 µM 0.278978189497107 0.426727041000798 no 1398 0.390130781392714 1823 2795203 SGTC_3326 9140064 16.379 µM 0.278133851824379 0.427035330913121 no 1399 0.390454805271109 1752 1868434 SGTC_970 1315-0089 19.5 µM 0.277350659937092 0.427321334740617 no 1400 0.390755431820757 1760 6811083 YLR033W RSC58 SGTC_450 aminopyrene 156 nM 0.276968447274389 0.427460923974375 no 1401 0.390902167066629 1904 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1164 k060-0068 93.7 µM 0.276129175232089 0.427767469315902 no 1402 0.391224426436238 1821 5963676 SGTC_256 clotrimazole 625 nM 0.275914417046217 0.427845917071599 no 1403 0.391306900191717 1815 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_703 3875-0075 71.8 µM 0.273858346678101 0.428597110866563 no 1404 0.392096741377204 1846 2850814 SGTC_1469 k284-2957 126 µM 0.272554070833083 0.429073767740654 no 1405 0.392598010858183 1882 23884841 SGTC_190 3970-0790 3.722 µM 0.271240182675204 0.429554042099077 no 1406 0.393103154817228 1919 2832352 SGTC_2855 9016525 58.44 µM 0.271061352180149 0.429619419288973 no 1407 0.393171922815712 1831 43811474 SGTC_2174 5790901 200 µM 0.270152436242502 0.429951732291752 no 1408 0.393521491478127 1818 786020 SGTC_1954 st077032 68.9 µM 0.26908071887505 0.43034363162973 no 1409 0.393933783764215 1730 698907 SGTC_2326 6164455 177.58 µM 0.268571906825229 0.430529715091177 no 1410 0.394129566657528 1808 2888790 SGTC_2841 9004761 38.96 µM 0.265740360695804 0.431565552832311 no 1411 0.395219588630384 1695 2991039 SGTC_3015 9080845 49.47 µM 0.263563332155331 0.432362275097688 no 1412 0.396058208186474 1939 5296973 SGTC_247 mechlorethamine 29.705 µM 0.262686489581226 0.43268324911433 no 1413 0.396396115470037 1868 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1327 1436-0082 2.18 µM 0.262190001608186 0.432865011528424 no 1414 0.396587480699939 1846 15992205 SGTC_483 fpl-64176 144 µM 0.261806592926998 0.433005385753721 no 1415 0.3967352779467 1869 3423 SGTC_1033 k072-0102 21.3 µM 0.260284906249512 0.433562591404404 no 1416 0.397322007267258 1965 5965931 SGTC_887 0885-0007 9.62 µM 0.259949787662122 0.433685321684981 no 1417 0.397451252988294 1921 5719458 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.258861678459321 0.434083863296571 no 1418 0.397870983365546 1899 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2512 diallyl trisulfide 49.23 µM 0.258586642900658 0.434184611159534 no 1419 0.397977095113176 1929 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2719 novobiocin 32.65 µM 0.257054991011232 0.434745746282305 no 1420 0.398568161113576 1947 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1335 1486-0900 202 µM 0.256761105158185 0.434853429205356 no 1421 0.398681598613961 1841 X1335 SGTC_2134 5324836 1.464 µM 0.255521969397581 0.435307514865994 no 1422 0.399159988763409 1867 699272 SGTC_3027 9089541 49.47 µM 0.254499194185352 0.435682378745107 no 1423 0.399554963275136 1847 9943819 SGTC_1043 0916-0009 19.3 µM 0.253764286558709 0.435951770140735 no 1424 0.399838832821343 2020 3101130 SGTC_691 1548-0686 185 µM 0.253316064760511 0.43611608715076 no 1425 0.40001199149169 1797 46495133 SGTC_36 0335-0881 14.2 µM 0.247943755576811 0.438086412692383 no 1426 0.402088962311317 1876 23828853 SGTC_3127 9126946 49.47 µM 0.245343555891241 0.439040605618028 no 1427 0.403095214676245 1787 27243249 SGTC_2047 4141938 200 µM 0.245326685214886 0.439046797797864 no 1428 0.403101745569941 1871 3807862 SGTC_189 3970-0742 2.116 µM 0.245220821056975 0.43908565431039 no 1429 0.403142727801759 1986 2891807 SGTC_1661 st013063 9.66 µM 0.244653853064318 0.439293764930429 no 1430 0.403362231077588 1863 721395 SGTC_3350 9150499 3.57 µM 0.243816022138862 0.439601328890378 no 1431 0.403686655436143 1880 4910996 YPR165W RHO1 SGTC_2734 clemastine 41.6 µM 0.243754361598537 0.439623965639678 no 1432 0.403710534212411 1927 26987 Clemastine is a selective histamine H1 antagonist. SGTC_890 0929-0006 47.2 µM 0.242608030040282 0.440044841483371 no 1433 0.404154529985164 1823 1378169 SGTC_699 0375-0592 111 µM 0.242598932938962 0.440048181757421 no 1434 0.404158053958242 2046 762578 SGTC_1176 0848-0131 83.3 µM 0.242512138236188 0.440080051254623 no 1435 0.404191676289415 2011 6769040 SGTC_2541 muurolladie-3-one 83.07 µM 0.2418003022423 0.440341439614854 no 1436 0.404467452351917 1905 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_63 0099-0242 26.702 µM 0.241632092053786 0.440403210714186 no 1437 0.404532626469805 2009 3898502 YLR359W ADE13 SGTC_3002 9075603 71.4286 µM 0.240650025561829 0.44076387964631 no 1438 0.404913187264611 1963 20105405 SGTC_830 4076-0286 57.8 µM 0.240187180409029 0.440933878947986 no 1439 0.405092575695726 1889 6866659 SGTC_2736 butenafine 14.65 µM 0.238279166337884 0.441634791755559 no 1440 0.405832289451588 1964 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_671 0560-0003 407 µM 0.237804634479685 0.441809140460049 no 1441 0.406016311989936 1933 3238678 SGTC_1240 0356-0016 42.1 µM 0.235645652368915 0.442602518262139 no 1442 0.406853822682862 1914 4305613 SGTC_1973 st070275 50.2 µM 0.23518647340994 0.442771286092882 no 1443 0.407032002120666 2005 17118334 SGTC_262 fenpropimorph 62.5 µM 0.234258563030334 0.443112364356311 no 1444 0.407392126423333 1867 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_729 4092-0585 94.1 µM 0.234097044329589 0.443171739187131 no 1445 0.407454820236798 1821 2169061 SGTC_3303 9125618 40.5795 µM 0.233650574239729 0.443335869764925 no 1446 0.407628130841863 1940 22695467 SGTC_1904 st060225 78 µM 0.233600512564842 0.44335427395971 no 1447 0.407647564893422 1844 66595 SGTC_2403 6032726 181.2 µM 0.231198575795663 0.444237441854597 no 1448 0.40858026819299 1870 2881040 SGTC_1452 4194-0072 190 µM 0.230931000463426 0.444335843827606 no 1449 0.408684203342095 2023 1343545 SGTC_282 k297-0036 65.7 µM 0.229163857520472 0.444985804082786 no 1450 0.409370781314699 1954 5061378 SGTC_1837 st055472 66.5 µM 0.229111702601297 0.445004989067951 no 1451 0.409391049003028 1935 676091 SGTC_3153 9100258 49.47 µM 0.228512276847467 0.445225494748419 no 1452 0.409624006520679 1846 25236848 SGTC_2925 9010536 32.5 µM 0.228315104995181 0.445298030397082 no 1453 0.409700641280183 1941 2994177 SGTC_1280 0880-0253 10.1 µM 0.228123718631275 0.445368439429858 no 1454 0.409775030694267 1900 6836607 SGTC_362 0310-0100 9.03 µM 0.228050236811933 0.445395473077227 no 1455 0.409803592993844 1887 790235 SGTC_2188 6126565 140.678 µM 0.227545364272582 0.445581220386089 no 1456 0.409999849309504 1986 874518 SGTC_2474 5321570 43.32 µM 0.226871259611047 0.445829248385118 no 1457 0.410261925436698 1997 2841384 SGTC_1411 3909-8223 150 µM 0.226426728473006 0.445992819412907 no 1458 0.410434770685757 2011 X1411 SGTC_630 4356-0227 183 µM 0.226272505575684 0.446049569887722 no 1459 0.410494740619507 1940 779312 SGTC_2709 st078560 56 µM 0.225693675110267 0.446262576018879 no 1460 0.410719838853813 2005 17250903 SGTC_1054 3429-0080 167 µM 0.225637186209658 0.446283364426226 no 1461 0.410741808091609 1978 1162877 SGTC_78 0336-0123 156.75 µM 0.225428781350258 0.446360060506039 no 1462 0.410822861761699 1824 6765896 SGTC_2591 skatole 100 µM 0.225062173711777 0.446494982423588 no 1463 0.410965453542775 1895 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3339 9145883 14.936 µM 0.223986488481874 0.446890900524137 no 1464 0.411383908390783 1989 2030670 SGTC_2125 5246583 200 µM 0.221251818990697 0.447897663987997 no 1465 0.412448181576255 2066 835267 SGTC_3235 9132602 49.47 µM 0.221186758794182 0.44792161989199 no 1466 0.412473509447543 1947 4912240 SGTC_3252 9135871 49.47 µM 0.22092611505591 0.448017593783419 no 1467 0.41257498145556 1984 17682838 SGTC_2433 5607874 27.82 µM 0.220002165554838 0.448357833717371 no 1468 0.412934734076792 1889 2252428 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.21985786932673 0.448410973541484 no 1469 0.412990924435329 1898 15053 SGTC_1902 st060212 70.5 µM 0.216993945413825 0.449465858148025 no 1470 0.414106531695782 2035 688944 SGTC_696 1560-0013 611 µM 0.21647060932268 0.449658660189351 no 1471 0.414310466202185 1980 1650269 SGTC_1719 st032227 49.2 µM 0.214194255276424 0.450497428569608 no 1472 0.415197787877732 1858 3125804 SGTC_837 0091-0265 12.5 µM 0.213517288620353 0.45074691336516 no 1473 0.415461752825888 1899 759367 SGTC_3114 9122766 49.47 µM 0.212974490427843 0.450946966668727 no 1474 0.415673429957226 1881 17176985 SGTC_1949 st076024 69.1 µM 0.211244665810988 0.451584592450887 no 1475 0.416348179393186 1817 2921930 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.210719930672383 0.451778038364194 no 1476 0.416552910680998 1936 4213774 SGTC_1455 4262-0120 131 µM 0.210351395905079 0.45191390717229 no 1477 0.416696712182091 1998 1529587 SGTC_676 falcarinol 140 µM 0.209492323439574 0.452230645811304 no 1478 0.417031963724375 2050 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2227 7312221 64.1025 µM 0.20709518417108 0.45311462737151 no 1479 0.417967761524591 2015 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2120 5538279 151.968 µM 0.207084039105522 0.45311873783005 no 1480 0.417972113436476 1947 2058197 SGTC_3161 9100388 49.47 µM 0.206017439428073 0.453512138126183 no 1481 0.418388644405076 1979 25236368 SGTC_202 3594-0513 34.79 µM 0.205704899110634 0.453627422888564 no 1482 0.418510715733006 2036 708429 SGTC_1662 st014054 52 µM 0.204977432306566 0.453895774066322 no 1483 0.41879487853386 2049 2838777 SGTC_2191 5911152 200 µM 0.204416297685409 0.454102782278338 no 1484 0.419014097679411 1956 2875902 SGTC_1364 1653-0028 37.6 µM 0.204388458106591 0.454113052904397 no 1485 0.419024974456862 1946 5718652 SGTC_184 1494-0393 24.714 µM 0.202977374193485 0.454633672491987 no 1486 0.419576358435763 1878 3090647 SGTC_936 3005-4620 401 µM 0.202384460407353 0.454852451415092 no 1487 0.419808087920692 2075 777207 SGTC_1074 carmofur 3.8 µM 0.201746352165291 0.455087921914192 no 1488 0.420057511896773 2026 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2634 4'-methoxyflavone 100 µM 0.201594531940105 0.455143947940399 no 1489 0.420116860172862 1908 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1371 2421-0008 32.7 µM 0.201587809645679 0.455146428680867 no 1490 0.420119488037247 1910 2827552 SGTC_906 1165-0455 526 µM 0.199342225841852 0.45597521781951 no 1491 0.420997525241039 1916 3252859 SGTC_1831 st055328 12 µM 0.198847848664738 0.456157706001024 no 1492 0.421190882736265 2044 1103068 SGTC_1574 spiramycin 23.7 µM 0.198826479238712 0.456165594251334 no 1493 0.421199241032176 1987 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.197441904345971 0.456676729049373 no 1494 0.421740870021732 2083 756377 SGTC_3023 9089636 49.47 µM 0.197222735518999 0.456757644819472 no 1495 0.421826619823549 2113 17249241 SGTC_465 cgp-37157 41 µM 0.196419831143408 0.457054087420196 no 1496 0.422140787785981 2078 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1137 ixabepilone 100 µM 0.19624129446826 0.457120008705966 no 1497 0.422210654033444 1878 154225 A novel microtubule stabilizer. SGTC_1481 3346-2004 36 µM 0.1959829285735 0.457215407507847 no 1498 0.422311763955372 2063 2770522 SGTC_2892 9047358 58.44 µM 0.195876853057173 0.45725457545495 no 1499 0.422353277446587 1944 6466771 SGTC_1478 0453-0656 35.7 µM 0.19476801436593 0.457664034354902 no 1500 0.422787281777664 2030 5258496 SGTC_1090 efavirenz 20.7 µM 0.194710632463605 0.457685224895049 no 1501 0.422809743861564 1996 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1021 4476-0760 85.3 µM 0.194676570461828 0.45769780369519 no 1502 0.422823077514203 1862 746768 SGTC_1051 3253-3903 78 µM 0.194277521207222 0.457845172256841 no 1503 0.422979292887652 2010 5509239 SGTC_1135 dihydrocapsaicin 536.708 nM 0.193053768602064 0.458297139140285 no 1504 0.423458429393835 1857 107982 A Capsaicinoid. SGTC_1242 0402-0103 60.1 µM 0.192530109204465 0.458490558060916 no 1505 0.423663492662331 1986 432868 SGTC_2602 kawain 100 µM 0.19222266010239 0.458604122093651 no 1506 0.423783898338757 2096 5369129 SGTC_838 0109-0203 71.4 µM 0.191900781598041 0.458723019608027 no 1507 0.423909962597754 1963 759422 SGTC_1415 3966-0071 78.1 µM 0.190862729736797 0.459106486863892 no 1508 0.424316570347334 2028 2893185 SGTC_2000 st075254 36.4 µM 0.188344159535558 0.460037030602814 no 1509 0.425303435215043 1958 17234175 SGTC_469 w7 172 µM 0.187922588806964 0.460192811141355 no 1510 0.425468667445537 2093 45115570 A P450 inhibitor. SGTC_2931 9014674 55.67 µM 0.187817506115357 0.460231642679341 no 1511 0.425509856043447 1967 2996810 SGTC_1766 st045414 44.774 µM 0.187598098785623 0.460312722183237 no 1512 0.425595858366719 2003 253960 SGTC_2520 obtusaquinone 4.71 µM 0.186784308426813 0.46061346361597 no 1513 0.425914875227081 2070 5967872 SGTC_2939 9044578 71.43 µM 0.18640112103238 0.460755080781435 no 1514 0.426065106689915 1960 2653634 SGTC_1618 st003135 44.5 µM 0.185852039199345 0.4609580173523 no 1515 0.426280396998864 2065 1270615 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.183615625171333 0.461784683872847 no 1516 0.427157502210515 1888 23665772 A membrane-active detergent. SGTC_3296 9122258 64.045 µM 0.181405786521938 0.462601689302375 no 1517 0.428024538622649 1964 4730474 SGTC_2973 9094665 17.96 µM 0.179771437634912 0.463206030556851 no 1518 0.42866600386805 2076 25237061 YIL048W NEO1 SGTC_3247 9135149 49.47 µM 0.178084836049694 0.463829782578398 no 1519 0.429328175377444 2075 8934436 YOR116C RPO31 SGTC_521 r062-0005 13.8 µM 0.177929081181125 0.463887389554856 no 1520 0.429389335882759 1953 2832033 SGTC_2919 7978188 46.38 µM 0.177918771441182 0.463891202707632 no 1521 0.429393384284126 2092 2980291 SGTC_805 3852-0218 479 µM 0.177522530159044 0.464037758724914 no 1522 0.429548984884415 1921 6615355 SGTC_1223 0764-0573 147 µM 0.176880466971943 0.464275246158482 no 1523 0.429801140895039 2018 1609797 SGTC_3093 9117344 49.47 µM 0.17646817248895 0.464427753065795 no 1524 0.429963075472508 2017 24824913 SGTC_2694 st077685 81.9 µM 0.174865464966701 0.465020640824594 no 1525 0.430592673539538 1974 2838096 SGTC_3148 9097893 49.47 µM 0.174440139124532 0.46517799422046 no 1526 0.430759785702501 1920 17174100 SGTC_616 4092-0450 108 µM 0.172843548947974 0.465768716532658 no 1527 0.431387202528023 2030 787165 SGTC_2884 9058502 51.95 µM 0.172726993735736 0.465811843759355 no 1528 0.431433012380006 2001 6471554 SGTC_1695 st026914 34.495 µM 0.172646979040202 0.465841450663597 no 1529 0.431464461197437 1976 3289191 SGTC_835 0312-0010 67.2 µM 0.172282215467385 0.465976422265645 no 1530 0.431607832651145 1976 1626196 SGTC_980 1473-0395 201 µM 0.172252467066428 0.465987430087338 no 1531 0.431619525750038 1951 768876 SGTC_854 0422-0053 192 µM 0.171721894305436 0.466183762661468 no 1532 0.431828086166068 2085 3596728 SGTC_252 miconazole 1.30953 nM 0.171409836899603 0.466299239895179 no 1533 0.431950760260939 2076 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2504 purpurogallin 52.29 µM 0.170660124778644 0.466576683381963 no 1534 0.432245509293109 1950 5281571 An antioxidant. SGTC_3343 9148379 18.9835 µM 0.170529372868314 0.466625071976403 no 1535 0.43229691822324 2110 1955036 SGTC_2553 4-methylesculetin 85.09 µM 0.17006875760407 0.466795540143083 no 1536 0.432478031685675 1932 5319502 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.169813349702948 0.466890066161023 no 1537 0.432578463934858 1978 5282362 SGTC_2505 galangin 7.89 µM 0.168905369693459 0.467226123059407 no 1538 0.432935537740694 1922 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1443 4112-3303 14 µM 0.167187542960785 0.467861979986042 no 1539 0.433611242872236 2017 704433 SGTC_199 4063-0024 41.6 µM 0.166954727022595 0.467948163607396 no 1540 0.433702835726559 2091 306215 SGTC_1188 1403-0014 4.57 µM 0.166426757792258 0.468143612403033 no 1541 0.433910558954731 1992 9614867 SGTC_2192 5915882 198.485 µM 0.162163280927142 0.469722185148256 no 1542 0.435588637299084 2093 2876149 SGTC_1821 st053465 65.6 µM 0.162119078062106 0.469738554006918 no 1543 0.435606041405729 2006 675086 SGTC_728 3030-5151 22.5 µM 0.162065898752612 0.469758247019936 no 1544 0.435626979995997 2027 3125388 SGTC_3192 9110362 49.47 µM 0.161566524782169 0.469943175514877 no 1545 0.435823610129339 2081 16649480 SGTC_1711 st032263 62.8 µM 0.160978217314958 0.470161046235362 no 1546 0.436055278469032 2052 3958979 SGTC_2653 dihydrofissinolide 100 µM 0.160265249663267 0.470425094925516 no 1547 0.436336065876407 2052 6857746 SGTC_249 wiskostatin 11.211 µM 0.159881880110649 0.470567081825363 no 1548 0.436487061235379 2104 2775510 A n-wasp and actin depolymerizer. SGTC_1840 st055363 71 µM 0.15900837187543 0.470890613187215 no 1549 0.436831138974989 1952 676033 SGTC_2659 sanguinarine 24.21 µM 0.158408321267166 0.471112872026379 no 1550 0.437067528572618 2048 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1526 st051518 75 µM 0.158030580918505 0.471252791730007 no 1551 0.437216350699711 1969 673993 SGTC_2798 7813637 45.45 µM 0.157246858904062 0.471543103370042 no 1552 0.437525149780953 2057 956368 SGTC_1391 3442-0225 151 µM 0.156797627291727 0.471709517627751 no 1553 0.437702171434464 2022 5227075 SGTC_807 1315-0151 48 µM 0.155502054580473 0.472189479738134 no 1554 0.438212767161672 2155 4011080 SGTC_1812 st052057 4.327 µM 0.15527805446331 0.472272467669798 no 1555 0.438301057881611 2072 3645418 SGTC_2969 9091408 28.7 µM 0.155216005676807 0.472295455819283 no 1556 0.438325515251591 1884 4286311 SGTC_419 nsc-638432 893 µM 0.15440168323311 0.472597158657636 no 1557 0.438646513273461 2026 368090 SGTC_547 1120-0019 610 nM 0.153583018796935 0.47290048603315 no 1558 0.438969263552243 2022 3676939 SGTC_618 k072-0232 33.2 µM 0.153213848624538 0.473037274236092 no 1559 0.439114818495332 2047 5872756 YGL099W LSG1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.152535898763057 0.473288482494459 no 1560 0.43938213929102 1987 688669 SGTC_1029 k015-0030 64.7 µM 0.15253222196828 0.473289844926937 no 1561 0.439383589154695 2044 2208316 SGTC_206 4546-0025 72.014 µM 0.152483015733956 0.473308078275911 no 1562 0.439402992636204 2033 6620745 YIL048W NEO1 SGTC_629 3448-6466 76.7 µM 0.152395337661075 0.4733405674867 no 1563 0.439437567068542 2076 573744 SGTC_3307 9126885 69.2785 µM 0.151174966684312 0.47379279567235 no 1564 0.43991884850731 1975 24824909 SGTC_1231 0242-0792 125 µM 0.15018254628724 0.474160578015168 no 1565 0.440310297878795 2006 3707635 SGTC_1053 3366-3204 134 µM 0.149062997724015 0.474575499367472 no 1566 0.440751961583444 1995 3632071 YPR165W RHO1 SGTC_1545 lovastatin 49.4 µM 0.147157625616964 0.475281721782398 no 1567 0.441503803125883 2048 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1183 1254-0324 198 µM 0.145611709794228 0.475854769608013 no 1568 0.442113961719629 2102 5799357 SGTC_982 1491-0518 27.5 µM 0.145310760502045 0.475966332844877 no 1569 0.44223275962363 2037 3091256 SGTC_2883 9059145 45.46 µM 0.145160555848652 0.476022015081208 no 1570 0.442292053941885 2066 16476510 SGTC_2874 9043904 71.43 µM 0.145109196739118 0.476041054479484 no 1571 0.442312328599687 2017 4463428 SGTC_3141 9094609 49.47 µM 0.144891743530946 0.476121667429689 no 1572 0.442398172676404 1927 25236309 YDL196W YDL196W SGTC_2791 5663188 71.43 µM 0.144710980500598 0.476188679561067 no 1573 0.442469534618054 2120 54690634 SGTC_330 1488-0319 80.1 µM 0.144688814186456 0.47619689706184 no 1574 0.442478285602413 2035 6846614 SGTC_2496 diffractaic acid 79.83 µM 0.14437092232303 0.476314747114129 no 1575 0.442603788430653 2138 94870 An apoptosis inducer which activates caspases. SGTC_302 1094-0063 18.9 µM 0.144106534937616 0.476412763366131 no 1576 0.442708172226909 2043 5440289 SGTC_1830 st055982 50.3 µM 0.143969226052443 0.47646366840926 no 1577 0.442762385243318 2177 455313 An antimicrobial agent. SGTC_1360 1598-0022 39.8 µM 0.14281672659007 0.476890953962375 no 1578 0.443217463295794 2107 761525 SGTC_2825 7998094 58.44 µM 0.142791028304554 0.476900481825613 no 1579 0.44322761142396 2076 2987815 SGTC_1408 3909-7976 48.8 µM 0.142604259293933 0.476969728459821 no 1580 0.443301366717732 2072 24152374 SGTC_2688 kanamycin b 96.69 µM 0.139887640863153 0.47797702173209 no 1581 0.444374383215727 2071 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_582 0987-0078 156 µM 0.139309378832546 0.478191453534335 no 1582 0.444602839456894 2163 1625765 SGTC_194 1486-1323 56.904 µM 0.139047216793083 0.478288670851975 no 1583 0.444706418906629 2018 5178754 SGTC_2966 9084041 48.03 µM 0.138829253382892 0.478369499014717 no 1584 0.444792538483032 1903 17741380 SGTC_2020 4017018 200 µM 0.137927981281843 0.47870373042846 no 1585 0.445148667945618 2070 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_828 2074-0507 139 µM 0.137262255098662 0.478950620665705 no 1586 0.445411752029073 2157 X828 SGTC_2330 7979373 200 µM 0.137241865966078 0.478958182277509 no 1587 0.445419809860328 1979 1863007 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.137046029031981 0.4790308116904 no 1588 0.445497206206942 2011 2374 Ca(2+)-ATPase inhibitor. SGTC_1175 0741-0056 27.6 µM 0.1369129816029 0.47908015495919 no 1589 0.445549788816479 2139 765927 SGTC_2926 9010726 65.15 µM 0.13670099588692 0.479158774714001 no 1590 0.445633571159697 2022 2994293 SGTC_310 1273-0058 1.06 µM 0.136635634287315 0.479183015722942 no 1591 0.445659404276774 2135 2734232 SGTC_1944 st076371 56.9 µM 0.135278377565042 0.479686406110579 no 1592 0.446195890060406 1989 24208455 SGTC_877 0771-0151 33.1 µM 0.134949198792219 0.47980849951777 no 1593 0.4463260201423 2080 6166523 SGTC_953 1188-0045 9.7 µM 0.134029100626338 0.480149776735347 no 1594 0.446689781533082 2101 6144426 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.133661707364938 0.480286052089237 no 1595 0.446835043240813 2008 803109 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.1329588083199 0.480546781341157 no 1596 0.447112978695606 2147 16486 A toxic proline analog. SGTC_1100 amiodarone 5.07 µM 0.131344448741762 0.481145633746101 no 1597 0.44775141565906 2197 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_489 paxilline 115 µM 0.130828037306596 0.481337207444929 no 1598 0.447955671525882 2054 105008 A toxic potassium channel blocker. SGTC_2572 astragaloside iv 100 µM 0.130550533649588 0.481440155054551 no 1599 0.448065438064096 2054 45006101 An anti-inflammatory agent. SGTC_2623 humulene 100 µM 0.128628681655343 0.482153152476059 no 1600 0.448825735076497 2067 6187145 An anti-inflammatory. SGTC_1744 st037937 38.9 µM 0.128059330416576 0.482364389985005 no 1601 0.44905101030593 2123 1016152 SGTC_3003 9075612 71.4286 µM 0.127942971700499 0.482407561355621 no 1602 0.449097051988012 2100 6501993 SGTC_2628 lathosterol 100 µM 0.127621098127793 0.482526983850298 no 1603 0.449224416885522 2099 6710616 SGTC_919 tnp00227 403.569 nM 0.127494888113999 0.482573811095204 no 1604 0.449274359430332 2084 1269246 A methoxyflavone. YNL221C POP1 SGTC_1042 0350-0096 82 µM 0.123217215265294 0.484161078550374 no 1605 0.450967546818765 1989 3122515 SGTC_1567 st069303 68.4 µM 0.12134581973788 0.484855556438709 no 1606 0.451708564614737 2083 5581319 SGTC_1648 st011736 69.8 µM 0.120640335849532 0.485117374680976 no 1607 0.451987959381882 2169 2855514 SGTC_3355 9151058 44.0485 µM 0.12047947868027 0.485177072681988 no 1608 0.452051667432882 2206 17015728 SGTC_3152 9099253 49.47 µM 0.119822599044582 0.485420860097557 no 1609 0.452311839734952 2155 25236131 SGTC_1232 0279-0259 161 µM 0.119688806857786 0.485470514996859 no 1610 0.452364833724544 2068 1560000 SGTC_3199 9111318 49.47 µM 0.11926807982627 0.485626662787169 no 1611 0.452531485782311 2150 8548020 SGTC_2565 isoliquiritigenin 100 µM 0.119163290570323 0.485665554406112 no 1612 0.452572994626751 1929 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2262 9014885 67.46 µM 0.117949221585252 0.486116155373245 no 1613 0.45305394611449 2167 6457424 SGTC_1152 3909-8331 15.9 µM 0.117845111956756 0.486154796432104 no 1614 0.453095192193728 2059 16001939 SGTC_2325 6158266 200 µM 0.117576158777476 0.486254620995219 no 1615 0.453201748215909 2102 3623240 SGTC_2961 9083290 32.55 µM 0.117511301670958 0.486278693464153 no 1616 0.453227444327771 2207 17741490 SGTC_3189 9110682 49.47 µM 0.115784134229546 0.486919769854568 no 1617 0.453911812494084 2090 17122418 SGTC_984 1492-0255 2.91 µM 0.115215504660017 0.487130836771232 no 1618 0.454137154787738 2129 1585198 SGTC_880 0833-0487 87.2 µM 0.114967624799983 0.487222847254118 no 1619 0.454235391757982 2185 76075 SGTC_204 PMA1.184 62.41 µM 0.114373381869345 0.4874434269463 no 1620 0.454470906850847 2208 2252213 YGL008C PMA1 SGTC_15 0266-0086 27.098 µM 0.111905711940285 0.488359452725793 no 1621 0.455449083790549 2216 1712902 YIL048W NEO1 SGTC_3134 9127454 49.47 µM 0.11178277807162 0.488405088753951 no 1622 0.45549782151971 2222 24262820 SGTC_2977 9011197 71.43 µM 0.110245769263767 0.488975676254242 no 1623 0.456107232423568 2196 2704722 SGTC_2270 7924575 90.91 µM 0.108463009717957 0.489637522581861 no 1624 0.45681421066827 2234 1262135 SGTC_1161 k007-0610 110 µM 0.108214195256272 0.489729896821308 no 1625 0.456912892447595 2223 5843850 SGTC_2065 5221596 34.26 µM 0.107391705477832 0.490035256228054 no 1626 0.457239117261212 2166 788581 SGTC_2769 toremifene 3.73 µM 0.107190699457722 0.490109883070539 no 1627 0.457318846838322 2169 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_258 haloperidol 50.781 µM 0.107177039581753 0.490114954540255 no 1628 0.457324265127144 2050 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_531 3788-1495 174 µM 0.107078223720015 0.490151641718147 no 1629 0.457363461391196 2069 2896655 SGTC_1642 st009582 77.7 µM 0.106945347294276 0.490200974628438 no 1630 0.45741616876001 2207 6739311 SGTC_2319 6033012 152.6 µM 0.106687157410319 0.490296832980861 no 1631 0.457518585677285 2141 847246 SGTC_1422 4031-0024 15.5 µM 0.106094881038755 0.490516729983201 no 1632 0.457753536281603 2215 782427 SGTC_3110 9122132 49.47 µM 0.106077818141196 0.490523065041788 no 1633 0.457760305195755 2182 918317 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.104693389308197 0.491037079219734 no 1634 0.458309553851433 2208 6710655 SGTC_3012 9080433 71.4286 µM 0.104598443301988 0.491072331564013 no 1635 0.458347224997942 2220 17688859 SGTC_3079 9117512 49.47 µM 0.104580437487222 0.491079016920819 no 1636 0.458354369097216 2235 7185044 SGTC_384 k007-0144 5.16 µM 0.104538926212278 0.491094429600553 no 1637 0.458370839420603 2129 6824886 SGTC_633 0437-0093 97.7 µM 0.104104567209638 0.491255703113112 no 1638 0.458543183222979 2198 2831118 SGTC_2658 polymyxin b sulfate 77.05 µM 0.103083761292834 0.491634724565041 no 1639 0.458948246484917 2146 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1649 st011737 51.3 µM 0.102764096372554 0.491753416533739 no 1640 0.459075100649728 2108 1761035 SGTC_3077 9117319 49.47 µM 0.10263029035874 0.491803099084708 no 1641 0.459128200770478 2242 17154678 SGTC_1174 0739-0097 51.1 µM 0.10075957331359 0.49249771457648 no 1642 0.459870659640968 2133 728447 SGTC_2152 5568786 200 µM 0.100459455433463 0.492609153446169 no 1643 0.459989784914378 2211 5399883 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0990692984955021 0.493125349731127 no 1644 0.460541624195436 2232 1273210 SGTC_591 4299-0174 154 µM 0.098768976890188 0.49323686738506 no 1645 0.460660850437666 2169 5509088 SGTC_1221 2958-7315 257 µM 0.0972869691771539 0.493787185092951 no 1646 0.461249252000461 2163 4562705 SGTC_1723 st034307 2.5525 µM 0.0968949821846123 0.493932744643986 no 1647 0.461404896847245 2157 867466 SGTC_2413 inermin 26.06 µM 0.0968906523587146 0.493934352476154 no 1648 0.461406616108491 2210 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_804 1595-0054 20.9 µM 0.0965580589977928 0.49405785757397 no 1649 0.461538682434631 2087 761523 Stimulates phospholipase C. SGTC_21 0849-0113 22.993 µM 0.096293727531813 0.494156014731323 no 1650 0.461643646321458 2191 1560156 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0961524674618571 0.494208470557229 no 1651 0.461699740648375 2215 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2276 7947513 42.08 µM 0.096093289182334 0.494230445979873 no 1652 0.461723240550057 1978 2105100 SGTC_1873 rapamycin 2 nM 0.0953775145645442 0.494496245032698 no 1653 0.462007487712463 2160 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2414 st077232 92.9 µM 0.0937615082785147 0.495096349075307 no 1654 0.462649304439901 1994 729801 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0931625962345939 0.495318757993749 no 1655 0.462887194497365 2236 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1339 1486-1321 22.7 µM 0.0923899923595522 0.495605670363078 no 1656 0.463194095180502 2116 3469382 SGTC_3214 9129694 49.47 µM 0.0920424749471535 0.495734724367166 no 1657 0.46333214633708 2221 17158655 SGTC_1734 st037168 69.4 µM 0.0920107054439087 0.495746522306679 no 1658 0.463344766980403 2054 708907 SGTC_2362 9071156 126 µM 0.09183684004579 0.495811089118422 no 1659 0.463413836802083 2221 653133 SGTC_2468 5987765 72.9 µM 0.0915288682539203 0.495925458070295 no 1660 0.463536184476728 2162 26772094 SGTC_3319 9138450 16.7555 µM 0.0914336081265458 0.495960834108719 no 1661 0.463574029080103 2113 2029690 SGTC_771 0250-0039 27.3 µM 0.0912299983825961 0.496036447237061 no 1662 0.463654919537192 2121 3005115 SGTC_1682 st012968 530 nM 0.0906869219542795 0.496238126425731 no 1663 0.46387068128853 2062 24207270 SGTC_619 1652-1634 108 µM 0.0889995810814824 0.496864750463341 no 1664 0.464541121524284 2153 5400454 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0889797471409441 0.496872116198876 no 1665 0.464549002853134 2250 551469 SGTC_277 nystatin 15.5 µM 0.0887156970002532 0.496970176667295 no 1666 0.464653928661879 2253 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2958 9077254 16.72 µM 0.0882068491225666 0.497159148337894 no 1667 0.464856136862855 2153 16457351 SGTC_2274 7947094 46.08 µM 0.0869216000190462 0.497636456146971 no 1668 0.465366915083342 2272 2971028 SGTC_2790 5423970 71.43 µM 0.0866920712813711 0.497721697476098 no 1669 0.465458139445611 2234 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1607 st000305 50.6 µM 0.0836218074418639 0.498861926426845 no 1670 0.466678563914833 2242 5457690 SGTC_2722 naftopidil 47.16 µM 0.0832422456335071 0.49900288822943 no 1671 0.466829461062093 2243 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_841 0251-0215 91.2 µM 0.0830639525053477 0.499069102840328 no 1672 0.46690034424634 2187 3888614 SGTC_751 0833-0568 350 µM 0.0822420618918491 0.49937433738186 no 1673 0.467227113080471 2189 6954252 SGTC_769 0302-0231 76 µM 0.0819898855124885 0.499467990974477 no 1674 0.467327378283753 2237 571869 YER009W NTF2 SGTC_3290 9121031 71.43 µM 0.081589138464385 0.499616820994028 no 1675 0.467486719373577 2194 17014854 SGTC_347 4534-1311 26.2 µM 0.0807744274120406 0.49991938970788 no 1676 0.46781067278442 2251 2862016 SGTC_2145 5634607 200 µM 0.0807562602178569 0.499926136671138 no 1677 0.467817896846406 2202 308662 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0807501875127976 0.499928391962603 no 1678 0.467820311618895 2246 91467 include heat shock SGTC_694 1315-0438 43.2 µM 0.080364557102964 0.499928391962603 no 1679 0.467973657516571 2211 6793154 SGTC_3076 9116187 49.47 µM 0.0802565361602027 0.499888274962773 no 1680 0.468016612887749 2246 27241210 SGTC_1625 st003711 30.1 µM 0.0802394193759278 0.499881918102666 no 1681 0.468023419544835 2229 24207034 YER133W GLC7 SGTC_2068 5226020 147 µM 0.079415744227754 0.499576020307422 no 1682 0.468350973055091 2225 1810509 SGTC_1449 4112-4002 201 µM 0.0793761681429496 0.499561322482525 no 1683 0.468366711943596 2096 2059539 SGTC_2532 xanthone 78.9 µM 0.0792349918331666 0.499508892220826 no 1684 0.468422856308132 2233 7020 An insecticide. SGTC_3238 9133470 49.47 µM 0.0791155934225681 0.499464549873344 no 1685 0.468470340316671 2273 3534688 SGTC_626 0214-0009 33 µM 0.0788529699093857 0.499367016412481 no 1686 0.468574785639018 2224 3437874 SGTC_323 4013-0906 34.3 µM 0.0774640544481734 0.498851199955244 no 1687 0.469127192857113 2269 2910086 SGTC_424 splitomicin 100 mM 0.0772995340547965 0.498790100359594 no 1688 0.469192630785103 2068 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_440 fluspirilene 35.1 µM 0.0768067369406705 0.498607085507051 no 1689 0.46938864563478 2216 3396 An atypical antipsychotic. SGTC_2038 4100038 30.985 µM 0.0768050774367067 0.498606469201413 no 1690 0.469389305731198 2200 3596803 SGTC_553 k007-0256 45.7 µM 0.0767899769620188 0.498600861195867 no 1691 0.469395312210176 2181 6287000 SGTC_652 0437-0092 114 µM 0.0732876090190808 0.497300163590197 no 1692 0.470788625877209 2262 3091274 SGTC_680 0417-1641 114 µM 0.0732324161581123 0.497279666444852 no 1693 0.470810585634551 2219 2835990 SGTC_767 0929-0023 86 µM 0.0731683813146908 0.49725588563384 no 1694 0.47083606349051 2277 1204563 SGTC_2889 9059656 51.95 µM 0.0730893602301536 0.497226539351167 no 1695 0.470867504159964 2231 3949838 SGTC_2427 5545055 42.75 µM 0.0727841160327476 0.497113180096442 no 1696 0.470988955499212 2221 5372858 SGTC_278 4092-0821 23.9 µM 0.0719802388559655 0.496814643479784 no 1697 0.471308817080109 2228 877900 SGTC_709 3807-1509 243 µM 0.0718292337657313 0.496758564772594 no 1698 0.471368903861076 2275 1886677 YPL242C IQG1 SGTC_2305 7443522 69.23 µM 0.0718249954260183 0.496756990782786 no 1699 0.471370590357938 2217 5415886 SGTC_1479 0549-0158 134 µM 0.0711891521324094 0.496520858606265 no 1700 0.471623607428371 2269 5440202 SGTC_290 2043-6722 48.1 µM 0.0706472194603101 0.496319602836297 no 1701 0.471839264288197 2255 773758 YLR208W SEC13 SGTC_2258 7960471 200 µM 0.0703529697712099 0.496210328677481 no 1702 0.471956361565711 2126 2974708 SGTC_1985 st071382 65.5 µM 0.0701435278282338 0.496132549355506 no 1703 0.472039710901137 2292 6123237 SGTC_2809 7964133 12.99 µM 0.0700572295777526 0.496100501283412 no 1704 0.47207405443507 2217 1253665 SGTC_2455 5377712 9.75 µM 0.0692171193962006 0.495788515868666 no 1705 0.47240839824054 2127 2243908 SGTC_3145 9085516 49.47 µM 0.0688328174224767 0.495645801375251 no 1706 0.472561347751161 2100 25236195 SGTC_666 0272-0154 136 µM 0.068821463313218 0.495641584918299 no 1707 0.472565866669261 2220 6870312 SGTC_727 3032-0951 202 µM 0.0676879916852448 0.495220661928548 no 1708 0.473017004317094 2218 3652836 SGTC_2525 harmine 47.85 µM 0.067218607324943 0.495046354140109 no 1709 0.4732038360613 2246 5280953 A monoamine oxidase inhibitor SGTC_708 3448-5400 146 µM 0.065106052253814 0.494261860422733 no 1710 0.474044780828594 2293 3462195 SGTC_1731 st035964 63 µM 0.0635597012602264 0.493687639517338 no 1711 0.474660410281352 2095 6739575 SGTC_116 0155-0182 31.788 µM 0.0633972445586416 0.49362731369709 no 1712 0.474725090681542 2141 771486 SGTC_787 4152-0075 138 µM 0.0627313690687472 0.493380052519843 no 1713 0.474990208836915 2160 9566539 SGTC_2767 sibutramine 71.45 µM 0.0625790421700282 0.493323488953338 no 1714 0.475050859313263 2279 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3331 9141060 1.957 µM 0.0624388030579337 0.493271414064822 no 1715 0.475106697427807 2238 4906567 YPR165W RHO1 SGTC_2952 9073731 13.78 µM 0.0615359146945362 0.49293614796312 no 1716 0.475466206399841 2257 16457353 SGTC_2924 9010168 62.78 µM 0.0612856129310614 0.49284320523464 no 1717 0.475565874240824 2228 2993929 SGTC_1829 berberine 14.4 µM 0.0610679274710445 0.492762373995971 no 1718 0.475652555815509 2299 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1612 st002233 45.4 µM 0.0602516381205021 0.492459271081875 no 1719 0.475977609555628 2300 1035021 SGTC_2251 lansoprazole 556 µM 0.059746372140262 0.492271658908269 no 1720 0.476178819024691 2122 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2165 5727197 32.143 µM 0.0594876805439683 0.492175603837182 no 1721 0.476281838801061 2198 1361712 SGTC_722 3534-0461 190 µM 0.0591362824299273 0.492045126531269 no 1722 0.476421779998327 2244 658262 SGTC_1573 oleylamine 1.06 µM 0.0584815237938504 0.491802010994088 no 1723 0.476682539590129 2266 5356789 An amine of the fatty acid oleic acid. SGTC_2983 9022671 12.99 µM 0.0578503512753776 0.491567655995755 no 1724 0.476933915393036 2321 6405161 SGTC_379 3970-0972 5.9 µM 0.0566621830339328 0.491126495880352 no 1725 0.477407149579787 2229 2898042 YBL034C STU1 SGTC_2099 5377090 177.372 µM 0.0562410724709336 0.490970142498924 no 1726 0.47757488091186 2241 2243829 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0560454334489053 0.49089750450985 no 1727 0.477652806678954 2292 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3269 9137823 49.47 µM 0.0551523418241036 0.490565916150067 no 1728 0.478008548410536 2251 17682936 SGTC_1128 3448-9350 235 µM 0.0548864834576169 0.490467209117304 no 1729 0.478114450142389 2159 619386 SGTC_3104 9120930 49.47 µM 0.0546877267717732 0.490393415760113 no 1730 0.478193623673842 2217 17014836 SGTC_2242 6630449 61.2675 µM 0.0546246615942271 0.490370001314864 no 1731 0.478218745488352 2237 691249 YDR170C SEC7 SGTC_1438 4092-1045 4 µM 0.0524467439657258 0.489561418574621 no 1732 0.47908636452199 2317 1351342 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0523240319437818 0.489515861245466 no 1733 0.479135252410008 2265 279621 SGTC_158 k038-0087 26.446 µM 0.0506581476294553 0.488897408807032 no 1734 0.479798963577711 2216 X158 SGTC_707 0865-0008 204 µM 0.0502840410792647 0.488758526965383 no 1735 0.479948020527414 2278 723043 SGTC_1383 3049-0032 20.7 µM 0.0495192595308416 0.48847461673643 no 1736 0.480252744570586 2308 712864 SGTC_416 estradiol valerate 100 µM 0.0491910156315496 0.488352764375704 no 1737 0.48038353554386 2222 13791 A steroid. SGTC_911 3456-4043 236 µM 0.0485119073730693 0.488100665837083 no 1738 0.480654137452194 2284 914281 SGTC_2621 lithochol-11-enic acid 100 µM 0.0470577193227557 0.487560858330433 no 1739 0.481233612536973 2322 6708711 SGTC_2464 5717415 7.67 µM 0.0466472832899156 0.487408504914245 no 1740 0.48139717320351 2322 5285744 SGTC_775 4577-0580 57.3 µM 0.0462758898374159 0.487270645645182 no 1741 0.481545177919946 2289 2006902 SGTC_1966 st070145 16.1 µM 0.0449339092622462 0.486772522409418 no 1742 0.482079994224184 2322 3748532 SGTC_792 4534-1957 155 µM 0.0422564308699367 0.485778744670706 no 1743 0.483147138684551 2209 1717904 SGTC_3341 9147222 25.867 µM 0.0421358570088425 0.485733994289479 no 1744 0.483195197891514 2272 1939759 SGTC_1098 clofazimine 15.1 µM 0.0402799609099767 0.485045210805909 no 1745 0.483934964844506 2318 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_456 gingerol 170 µM 0.0396156224497394 0.48479866390511 no 1746 0.484199786151231 2303 442793 A herb. SGTC_1735 st034310 56.75 µM 0.03936696442096 0.484706384321075 no 1747 0.484298909027725 2258 871153 SGTC_2285 7945142 200 µM 0.0393509667097688 0.48470044743184 no 1748 0.484305286249628 2311 2970608 SGTC_1077 5-fluorocytosine 377 nM 0.0393212483075006 0.484689418684268 no 1749 0.484317133007833 2284 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1094 duloxetine 25.4 µM 0.037918741077207 0.484168949991036 no 1750 0.484876235287626 2343 60834 A selective serotonin reuptake inhibitor. SGTC_425 3825-7017 13.1 µM 0.0357643860195874 0.483369524346055 no 1751 0.485735115363986 2280 3397440 SGTC_13 0199-0087 65 µM 0.0354700137067342 0.483260295486242 no 1752 0.485852478459198 2345 4589825 SGTC_1470 k295-0292 231 µM 0.0351153105119525 0.483128682109799 no 1753 0.485993896459267 2334 5045612 SGTC_1326 1431-2094 10.8 µM 0.0345302394053975 0.482911594252563 no 1754 0.486227164581049 2340 616278 SGTC_2201 6605497 169.863 µM 0.0339547682390283 0.482698073349322 no 1755 0.486456609799972 2323 670741 SGTC_2703 st077852 53.4 µM 0.0337651070251172 0.482627703168998 no 1756 0.486532230315328 2310 6281836 SGTC_198 3454-2873 16.191 µM 0.0335725654849827 0.482556264852106 no 1757 0.486608999751416 2317 710957 SGTC_314 1671-0008 2.74 µM 0.0334349141618221 0.482505192689913 no 1758 0.48666388387176 2319 3913060 SGTC_2928 9011484 9.79 µM 0.0329086824591577 0.482309949920404 no 1759 0.486873704473099 2314 2994751 SGTC_1500 4488-1866 171 µM 0.032613431868349 0.482200407742227 no 1760 0.48699142922349 2340 2900003 SGTC_1683 st010134 710 nM 0.0322784306589705 0.482076119145659 no 1761 0.487125005040565 2350 3818134 SGTC_1602 st001878 87.6 µM 0.0276392890123261 0.480355138409252 no 1762 0.488974922762372 2336 595405 YLR310C CDC25 SGTC_1628 st004252 77.7 µM 0.0274481749998258 0.480284248543594 no 1763 0.489051137306381 2348 692968 SGTC_1281 0884-0031 11.8 µM 0.027038915738947 0.480132444223943 no 1764 0.489214347548613 2353 1548255 SGTC_1755 st041960 45.185 µM 0.0267848462271526 0.4800382050451 no 1765 0.489315669920782 2336 2257073 SGTC_300 r073-0011 5.04 µM 0.0259584720642771 0.479731695009423 no 1766 0.489645230885523 2363 2735780 SGTC_2049 5262831 67.185 µM 0.0246767039510129 0.479256298803241 no 1767 0.490156418487754 2337 763417 SGTC_2102 5377816 72.7585 µM 0.0227259832446056 0.478532850979027 no 1768 0.49093442477683 2350 1379702 SGTC_2972 9093619 59.92 µM 0.022583964818307 0.478480184500679 no 1769 0.490991067393913 2369 25236256 SGTC_2963 9082507 9 µM 0.0219453103304296 0.47824334888613 no 1770 0.49124579052462 2355 16459611 SGTC_441 propafenone 146 µM 0.021860332288475 0.478211836607631 no 1771 0.491279683727622 2369 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_49 0717-0965 32.132 µM 0.0215123874812575 0.478082810184952 no 1772 0.491418460984583 2353 5889349 YGL099W LSG1 SGTC_3177 9107506 49.47 µM 0.0212782155332712 0.477995974806406 no 1773 0.491511860695583 2370 8897194 SGTC_2349 9023730 187.07 µM 0.0210561313042788 0.477913622747278 no 1774 0.49160043963807 2358 4126287 SGTC_334 1502-1024 68.5 µM 0.020254532701769 0.477616386208159 no 1775 0.491920162992865 2309 3296216 SGTC_644 1498-1197 63.3 µM 0.0186361557352914 0.477016322518685 no 1776 0.492565679866574 2346 6741615 SGTC_2996 9066192 71.4286 µM 0.0179632330809194 0.476766830736544 no 1777 0.492834092213213 2360 6472854 SGTC_2710 st078562 53.7235 µM 0.0175067583741276 0.476597594045096 no 1778 0.493016170635284 2374 17250908 SGTC_3353 9151644 39.2805 µM 0.0174892123022527 0.4765910889732 no 1779 0.493023169433683 2347 4909158 SGTC_1248 0469-0687 58.6 µM 0.0169464820314844 0.476389878967231 no 1780 0.493239655391419 2354 4017482 SGTC_2487 5918373 44.05 µM 0.0159307417972262 0.47601332304454 no 1781 0.493644822351935 2380 2876279 SGTC_2664 lyso-paf C-16 73.48 µM 0.0158545955422839 0.475985094911138 no 1782 0.493675196476375 2379 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1292 0kpi-0043 232 µM 0.0158305436334822 0.475976178667207 no 1783 0.493684790595645 2362 3333905 SGTC_1880 MG-132 525 µM 0.0155418970919372 0.475869175917701 no 1784 0.493799929738462 2373 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1959 st077091 55.8 µM 0.0155061419807146 0.475855921436042 no 1785 0.493814192245367 2372 821356 YKL052C ASK1 SGTC_1671 st016596 74.5 µM 0.0144982442141303 0.47548230303395 no 1786 0.494216240015617 2377 2829167 SGTC_4 0960-0234 25.671 µM 0.0125930147397304 0.474776111201545 no 1787 0.494976246764118 2314 6821112 SGTC_831 k061-1017 217 µM 0.0118841565764345 0.474513386137363 no 1788 0.495259019072312 2374 1240153 SGTC_2232 chlorophetanol 41.5365 µM 0.0112450532042462 0.474276523883774 no 1789 0.495513967375713 2386 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2910 7948405 25.97 µM 0.0104070166297676 0.473965947495076 no 1790 0.495848275996447 2377 2971328 SGTC_2445 5742597 35.57 µM 0.0103976239955415 0.473962466673759 no 1791 0.495852022912635 2374 1774255 SGTC_1743 st037606 46.3785 µM 0.0102161540468835 0.473895216019418 no 1792 0.495924415102393 2383 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2295 7971645 200 µM 0.010212670001157 0.473893924879828 no 1793 0.495925804963033 2372 2978226 YKL099C UTP11 SGTC_452 diindolylmethane 8 µM 0.00904046479651927 0.473459537351403 no 1794 0.496393425485813 2384 3071 Inhibits expression of several cancer promoting factors. SGTC_2521 angolensin 13.4 µM 0.00801778470306432 0.473080585540699 no 1795 0.496801400957083 2377 821428 A flavenoid. SGTC_328 k915-0120 63.5 µM 0.0068817668958451 0.472659665270616 no 1796 0.497254593891215 2388 6624543 SGTC_98 0074-0023 107.663 µM 0.00639842446957647 0.472480585209458 no 1797 0.497447415368209 2383 3563821 SGTC_1698 5-fluorocytosine 1.055 µM 0.00530990843414007 0.472077306632349 no 1798 0.49788166297503 2397 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2812 7970281 58.44 µM 0.00514179033438398 0.472015023983906 no 1799 0.497948731477234 2392 2233435 SGTC_1172 0370-0043 85 µM 0.00366063945300007 0.471466332324107 no 1800 0.498539619410479 2396 376585 SGTC_940 3232-1287 54.8 µM 0.00297210987411216 0.471211285235107 no 1801 0.498814301454851 2401 1585493 YIL048W NEO1 SGTC_2787 5284540 71.43 µM 0.0026136569112952 0.471078510733757 no 1802 0.498957302938767 2396 736958 SGTC_1261 0712-0010 12.7 µM 0.00160765902088718 0.470705896443905 no 1803 0.499358637120374 2400 2840123 SGTC_1107 amlodipine 47 µM 0.000679214712782204 0.470362030184784 no 1804 0.499729032554435 2404 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1388 3346-4487 254 µM 0 0.470110484628145 no 1805 0.5 2405 3345614 SGTC_2723 salbutamol 83.58 µM -0.00185898349112669 0.469422075796216 no 1806 0.499258373313976 2402 9884233 β2-adrenoceptor agonist SGTC_2359 9039622 200 µM -0.00276311427690134 0.469087295823682 no 1807 0.498897678292031 2410 6463596 SGTC_3001 9076041 71.4286 µM -0.00525149946541006 0.468166014449807 no 1808 0.497904964457315 2420 16004211 SGTC_210 3551-0445 56.827 µM -0.00607168735051165 0.467862391249545 no 1809 0.497577762085301 2402 2865180 YOR207C RET1 SGTC_2282 7944268 200 µM -0.00727299191531837 0.46741771725851 no 1810 0.497098521599617 2415 2970414 SGTC_1861 st057647 17.4 µM -0.00814596340817827 0.467094604265684 no 1811 0.496750266722188 2427 688668 SGTC_2539 epi(13)torulosol 80 µM -0.00938728002938803 0.466635193054065 no 1812 0.496255072099538 2429 6708597 SGTC_1097 itavastatin 7.23 µM -0.00958453407508041 0.466562193419943 no 1813 0.496176382661272 2431 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3167 9103034 49.47 µM -0.0107320069587454 0.466137559869605 no 1814 0.495718630855895 2424 5127859 SGTC_2927 9011802 47.9 µM -0.0111777993847774 0.465972600397357 no 1815 0.495540796081628 2441 43912568 SGTC_2333 9017922 200 µM -0.0111912651824385 0.465967617651443 no 1816 0.495535424341597 2437 3163164 SGTC_1510 1123-0200 71.5 µM -0.0123261983546856 0.465547677849498 no 1817 0.495082682838916 2433 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_995 3931-2021 34.6 µM -0.0125688424610038 0.46545790138578 no 1818 0.494985889344973 2434 730143 SGTC_1506 4226-2149 212 µM -0.0128872056206444 0.465340112118618 no 1819 0.494858891108045 2459 991114 SGTC_548 1436-0017 110 µM -0.013319522384022 0.465180166707788 no 1820 0.494686436479656 2429 9677137 SGTC_1062 mesoridazine 14.2 µM -0.0149561627821008 0.464574705575245 no 1821 0.494033576749509 2434 4078 A neuroleptic. SGTC_3248 9135562 49.47 µM -0.0151166244131691 0.464515348557902 no 1822 0.493969569056821 2435 17650701 SGTC_2006 4011487 200 µM -0.0152226222218901 0.464476138908577 no 1823 0.493927286914522 2438 45595294 SGTC_2859 9028643 45.46 µM -0.0153015984557265 0.46444692503424 no 1824 0.493895783624982 2453 17151580 SGTC_174 3553-0389 74.3 µM -0.0153110906922005 0.464443413800907 no 1825 0.493891997214091 2442 738071 SGTC_3308 9128332 17.569 µM -0.0154390096784005 0.464396096096096 no 1826 0.493840970953525 2436 17332805 YDL196W YDL196W SGTC_2112 5488546 200 µM -0.0155769416746098 0.464345075106173 no 1827 0.493785950664974 2432 600757 SGTC_220 paclitaxel 373.376 µM -0.0158793230240983 0.464233226419254 no 1828 0.493665332880101 2424 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_930 2810-3379 265 µM -0.015990621222319 0.464192058727182 no 1829 0.493620936960059 2432 1015764 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0172383712419438 0.463730559281659 no 1830 0.493123225453394 2451 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1833 st055984 71 µM -0.0174580667427127 0.463649306572602 no 1831 0.493035592817481 2442 676288 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0185435568057593 0.463247868651821 no 1832 0.492602615112028 2468 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2373 9071805 200 µM -0.0195924241528092 0.462860010155617 no 1833 0.492184253662501 2443 10149009 SGTC_50 0929-0078 56.389 µM -0.0206082741543652 0.462484394728063 no 1834 0.491779070023985 2523 1377751 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0209390358627933 0.462362101197184 no 1835 0.491647143663492 2448 147795 SGTC_313 3474-0040 5.03 µM -0.0210174394402381 0.462333113325604 no 1836 0.491615872043388 2442 1043375 YIL048W NEO1 SGTC_99 0109-0120 622.8 µM -0.0224152699810841 0.4618163322101 no 1837 0.491058349864435 2451 759414 SGTC_1036 k216-0215 33.5 µM -0.0224305264223257 0.461810692223255 no 1838 0.491052264954872 2447 622330 SGTC_551 k048-0028 34.9 µM -0.0228414646866824 0.461658779845232 no 1839 0.490888366302993 2458 6836383 SGTC_3187 9109394 49.47 µM -0.0237947685377365 0.461306391662456 no 1840 0.490508156485793 2479 17098090 SGTC_900 1112-0045 141 µM -0.0241863839177356 0.461161640064998 no 1841 0.490351969507053 2444 56211 YIL048W NEO1 SGTC_2171 5739187 198.077 µM -0.0243967443687533 0.461083887296735 no 1842 0.490268072585776 2448 2262761 SGTC_2299 7976368 114.88 µM -0.0286803672398928 0.459500915808357 no 1843 0.488559757299676 2475 2979718 SGTC_3142 9086498 49.47 µM -0.0318772662202521 0.45831994948614 no 1844 0.487284964176272 2460 25236367 SGTC_490 phenamil 164 µM -0.03212948960304 0.458226791175418 no 1845 0.48718439312148 2468 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1922 5578187 25 µM -0.0321428503755346 0.458221856459007 no 1846 0.487179065696049 2465 1350412 SGTC_1791 st048313 56.1 µM -0.0336172398897275 0.457677339793842 no 1847 0.486591187297073 2471 1204976 SGTC_693 4161-2696 114 µM -0.0363388209420899 0.456672423852653 no 1848 0.485506097866671 2506 805759 SGTC_1633 st005664 67.9 µM -0.0380739873011446 0.456031875646719 no 1849 0.48481434569695 2473 2063822 SGTC_369 0957-0393 4.5 µM -0.0384061097869174 0.45590928339819 no 1850 0.484681944836086 2482 6997992 SGTC_1109 tnp00067 928.257 nM -0.0397640534725263 0.455408086300238 no 1851 0.484140617362731 2483 676295 SGTC_2506 ethyl hematommate 54.16 µM -0.0401396453393245 0.455269473345103 no 1852 0.483990897423223 2523 3940691 An allergen. SGTC_1813 st051246 8.6015 µM -0.0418448460098377 0.454640234240803 no 1853 0.483311192177621 2488 5291959 SGTC_3072 9116419 49.47 µM -0.0431853939943978 0.45414563609038 no 1854 0.482776874065384 2505 17170162 SGTC_1024 4507-0395 26 µM -0.0435560780480084 0.454008883902428 no 1855 0.482629131543312 2626 4201836 SGTC_1962 st076595 64.5 µM -0.0442970635197171 0.453735537046298 no 1856 0.48233380617531 2494 279619 SGTC_2995 9067767 71.4286 µM -0.0445545289525857 0.453640564104424 no 1857 0.482231193639346 2518 11673567 SGTC_3286 9117135 37.221 µM -0.0448278879236918 0.45353973131195 no 1858 0.482122248041473 2510 3438150 SGTC_2244 6635614 200 µM -0.0451664344271728 0.453414857216345 no 1859 0.481987324190325 2494 836499 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0452639419084103 0.453378892084949 no 1860 0.481948464076794 2487 688664 SGTC_1956 st077085 54 µM -0.0472884706977176 0.452632241910776 no 1861 0.481141658427165 2526 24208685 SGTC_2189 6047310 154.431 µM -0.0478972421295321 0.452407758445171 no 1862 0.480899068665899 2470 711535 SGTC_2683 piperine 63.03 µM -0.0485377145037872 0.452171601731589 no 1863 0.480643854010735 2492 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3095 9117207 49.47 µM -0.0495174202860725 0.451810394719917 no 1864 0.480253477424035 2478 17015229 SGTC_3236 9132701 49.47 µM -0.0505649058028501 0.451424242177648 no 1865 0.479836114073158 2504 24282524 SGTC_1186 1319-0216 26 µM -0.0507260134231682 0.451364854382789 no 1866 0.479771923807413 2543 4565136 SGTC_2803 7707263 71.43 µM -0.0514369039145689 0.451102817605531 no 1867 0.479488689304848 2515 2199229 SGTC_2409 alverine citrate 63.97 µM -0.053326905076568 0.450406260349294 no 1868 0.478735721772398 2779 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2178 5812956 200 µM -0.053927020773913 0.450185120402883 no 1869 0.478496654259737 2485 5403383 SGTC_738 1315-0003 72.4 µM -0.0545267273326043 0.449964146672467 no 1870 0.478257757464004 2534 6251474 SGTC_1362 1611-0397 101 µM -0.0552089720951591 0.449712778976095 no 1871 0.477985990570459 2510 27816 SGTC_2346 9031566 143.75 µM -0.0556933189303903 0.449534337449213 no 1872 0.477793060982314 2564 4771086 SGTC_1459 k035-0031 35.7 µM -0.0560285277275921 0.449410846858939 no 1873 0.477659540505073 2482 3877128 YMR208W ERG12 SGTC_3091 9116372 49.47 µM -0.0564220876512115 0.449265866025391 no 1874 0.477502780789695 2643 17169793 SGTC_2300 7976697 71.57 µM -0.057585412922503 0.448837356302308 no 1875 0.477039434596023 2524 2236109 SGTC_1672 st016598 6.51 µM -0.0576751420353522 0.448804307144108 no 1876 0.477003697254742 2580 4665860 YNL267W PIK1 SGTC_2827 7993847 71.43 µM -0.0589107308319243 0.448349249493919 no 1877 0.476511605464813 2558 2985692 SGTC_1847 st056231 15 µM -0.0592372284460783 0.448229014312891 no 1878 0.476381578839942 2505 5393180 SGTC_341 1486-1430 230 µM -0.0621442650089435 0.447158687367191 no 1879 0.475223973358356 2514 2054753 YPL210C SRP72 SGTC_513 4245-1575 41.7 µM -0.0632817427963516 0.446739989521537 no 1880 0.474771076879555 2642 719745 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0634242720485738 0.446687529647796 no 1881 0.474714329928922 2587 688751 SGTC_2708 st078559 56 µM -0.0644848610898608 0.446297194460762 no 1882 0.474292080560934 2521 17250902 SGTC_1352 1496-0991 99 µM -0.0654894974384267 0.445927499872442 no 1883 0.473892134107803 2525 3000039 SGTC_375 3970-0961 9.27 µM -0.0656003931820115 0.445886694392784 no 1884 0.473847988037761 2555 2898222 SGTC_2611 pyromycin 23.93 µM -0.066114011957959 0.44569770940408 no 1885 0.473643527665195 2552 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3306 9127676 59.7925 µM -0.0663248237628675 0.445620145195961 no 1886 0.473559610114715 2564 41905287 SGTC_1156 4092-0367 4.88 µM -0.0676615767007645 0.445128360851103 no 1887 0.473027518267355 2552 1357585 SGTC_3143 9086658 49.47 µM -0.0682634441473263 0.44490696451805 no 1888 0.47278796178273 2603 25236626 SGTC_2416 tofa 880 nM -0.0684326728642745 0.444844716997506 no 1889 0.472720606799394 2574 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_373 0844-0104 25.9 µM -0.0695559399296761 0.444431579412882 no 1890 0.472273553400528 2554 5375804 SGTC_466 geldanamycin 89.2 µM -0.0698962830380112 0.444306413126112 no 1891 0.472138105800805 2537 5288382 HSP90 inhibitor. SGTC_1554 st069299 38.7 µM -0.0704704221093776 0.444095277458672 no 1892 0.471909620871508 2588 24207999 SGTC_2955 9076254 12.21 µM -0.0713607078630634 0.443767912433843 no 1893 0.471555340217128 2539 16459619 SGTC_1296 1068-0102 11.9 µM -0.0715663520593292 0.443692300903526 no 1894 0.471473509276462 2604 767053 SGTC_857 0438-0306 1.35 µM -0.073932731978063 0.442822375393709 no 1895 0.470531955379128 2598 4686136 SGTC_405 ebelactone b 50 µM -0.0742746158354242 0.442696715178894 no 1896 0.470395937428664 2564 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3244 9134489 49.47 µM -0.0744099221210428 0.442646984627204 no 1897 0.470342106990594 2603 16584271 SGTC_983 1491-0821 12.2 µM -0.0745574684958549 0.442592756375931 no 1898 0.47028340755643 2613 46495113 SGTC_3208 9114115 49.47 µM -0.0764699729829049 0.441889944388977 no 1899 0.469522601047844 2609 650895 SGTC_2697 mebhydrolin 72.4 µM -0.0773353837717688 0.441571981014142 no 1900 0.469178371501945 2583 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2861 9024595 19.48 µM -0.0776407420739943 0.441459797308978 no 1901 0.469056916345549 2515 16482810 SGTC_1782 st039423 80.636 µM -0.077813291029182 0.441396407687568 no 1902 0.468988286897436 2585 2068169 SGTC_2589 lobaric acid 100 µM -0.07787091869262 0.44137523724305 no 1903 0.468965366333629 2577 73157 A novel microtubule depolymerizer. SGTC_2570 licareol 100 µM -0.0784484468445781 0.441163082293452 no 1904 0.468735668615809 2652 443158 SGTC_260 nsc-65238 3.989 µM -0.0786231465994353 0.441098909666801 no 1905 0.468666188101489 2550 3246252 SGTC_2747 doxorubicin 7.63 µM -0.0786369778777805 0.441093829076252 no 1906 0.468660687251093 2531 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2986 9022445 71.43 µM -0.0793662488767692 0.440825962502043 no 1907 0.468370656713068 2532 6459286 SGTC_912 3474-0017 2.18 µM -0.0815934992673372 0.440008045242776 no 1908 0.467484985446022 2651 3360550 SGTC_2421 5690543 90.72 µM -0.0820384974373271 0.439844658313468 no 1909 0.46730805004507 2608 3397993 SGTC_132 0417-1715 25.805 µM -0.083326890743363 0.439371665636379 no 1910 0.466795809460695 2571 6769098 SGTC_2656 pseudo-anisatin 100 µM -0.0834794777693502 0.439315653875234 no 1911 0.466735147397402 2560 6708809 A neurotoxin. SGTC_387 norethindrone acetate 66.7 µM -0.0837821711508526 0.43920454455601 no 1912 0.466614811767262 2603 541197 SGTC_3260 9137109 49.47 µM -0.0858655801661434 0.438439920346986 no 1913 0.465786636735518 2516 17478346 SGTC_1225 1216-0074 20.6 µM -0.0870520806885394 0.438004569678064 no 1914 0.465315057395205 2588 4241466 SGTC_811 0416-0114 265 µM -0.0874895766038103 0.437844062618589 no 1915 0.465141185163429 2633 6612453 SGTC_1005 4092-0690 4.4 µM -0.0875389347978173 0.437825954888494 no 1916 0.465121569353209 2604 1529343 SGTC_2657 nystatin 74.44 µM -0.08785427870305 0.437710269728658 no 1917 0.464996248168289 2614 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2930 9013230 14.89 µM -0.0895959417706687 0.437071429908527 no 1918 0.46430415471782 2616 2995857 SGTC_1579 chlormadinone acetate 49.4 µM -0.092546720612786 0.435989463211673 no 1919 0.463131836392268 2661 45114258 A steroidal progestin. SGTC_1204 4049-0315 18.3 µM -0.0931237659778643 0.435777932810457 no 1920 0.462902618476668 2818 588402 SGTC_590 k048-0076 22.4 µM -0.0932965363330396 0.435714603089496 no 1921 0.462833991844365 2634 6832814 SGTC_2138 5575593 77.673 µM -0.0940285227092457 0.435446308623397 no 1922 0.462543249630372 2572 762213 SGTC_2237 6667747 47.222 µM -0.0947394039151747 0.435185778258414 no 1923 0.462260909461877 2635 729940 YDL015C TSC13 SGTC_2269 7935389 174.42 µM -0.0948686131996992 0.435138427454706 no 1924 0.462209593542848 2563 97605 SGTC_269 exalamide 29 µM -0.0986137705403828 0.433766361688551 no 1925 0.460722468003701 2618 3316 A derivative of salicylamide. SGTC_2625 euphol 100 µM -0.0987157020592585 0.433729029408169 no 1926 0.460682000660606 2646 6708538 A triterpene alcohol. SGTC_2951 9072950 58.06 µM -0.0999372672200406 0.433281678915574 no 1927 0.460197064737878 2566 16488155 SGTC_800 3448-7362 155 µM -0.101659263320713 0.43265121044309 no 1928 0.459513568863636 2575 15991913 SGTC_746 1095-0025 46.6 µM -0.102536049778753 0.432330261411832 no 1929 0.459165600021845 2655 6749286 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.103057241408487 0.432139499558939 no 1930 0.458958770339095 2682 6708739 YPR165W RHO1 SGTC_955 1216-0110 33 µM -0.105744859127886 0.431156054076908 no 1931 0.457892393709383 2570 3619719 SGTC_2914 7968218 45.32 µM -0.108093957691406 0.43029682778128 no 1932 0.456960580567441 2673 2977111 SGTC_18 0111-0177 500 nM -0.108419957862663 0.430177613161502 no 1933 0.456831285183513 2595 721752 SGTC_2965 9082772 38.63 µM -0.110882926253784 0.429277139579333 no 1934 0.455854592489397 2659 16459634 SGTC_2224 6650123 117.647 µM -0.110919974463399 0.429263597365208 no 1935 0.455839903004452 2590 2908370 SGTC_3250 9135583 49.47 µM -0.11263458939693 0.428636946341055 no 1936 0.455160130580641 2746 7699353 SGTC_3102 9121669 49.47 µM -0.113715201269089 0.428242100674232 no 1937 0.454731780910525 2640 41905072 SGTC_1800 st050079 29.0735 µM -0.114182068419551 0.428071533896598 no 1938 0.45454673313183 2658 3645560 SGTC_311 1315-0136 58 µM -0.114202636964771 0.428064019625591 no 1939 0.454538580795945 2743 6759207 SGTC_480 am 92016 50 µM -0.114826555005127 0.427836097137639 no 1940 0.454291300209698 2668 2129 K+ channel blocker. SGTC_2834 9001755 58.44 µM -0.115103194847984 0.427735045985134 no 1941 0.45418166380749 2751 2989575 SGTC_3255 9139072 49.47 µM -0.11515637187045 0.427715621996333 no 1942 0.454160589378113 2678 17646060 SGTC_506 n9-isopropylolomoucine 153 µM -0.1184182907464 0.42652447652611 no 1943 0.452868116912987 2603 6610355 SGTC_433 pimozide 108 µM -0.118496329576706 0.42649598747391 no 1944 0.452837201590739 2607 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.1188122130743 0.426380674167136 no 1945 0.452712066295767 2605 1377 SGTC_556 4058-0063 51.5 µM -0.118994546540105 0.426314116178734 no 1946 0.452639838157341 2630 6615692 SGTC_1988 st071872 53.4 µM -0.119802282879305 0.426019289890476 no 1947 0.452319886746969 2608 16414116 SGTC_2342 7990637 118.86 µM -0.120733900967027 0.425679297731469 no 1948 0.451950903154658 2710 2033102 YER133W GLC7 SGTC_426 0988-0037 14.6 µM -0.121942053561873 0.425238467174349 no 1949 0.451472455100492 2593 5383008 SGTC_2381 9035592 200 µM -0.122332961583248 0.425095852692366 no 1950 0.451317664232362 2659 4749657 SGTC_71 0417-1750 47.813 µM -0.123808756000125 0.424557528976699 no 1951 0.450733349436986 2687 6811472 SGTC_1345 1488-0192 31.4 µM -0.12389695916487 0.424525359662319 no 1952 0.450698430316464 2658 658348 SGTC_3026 9090633 49.47 µM -0.124455269462691 0.424321745312342 no 1953 0.450477407376377 2620 25236842 SGTC_1912 st060209 90.8 µM -0.126685605267591 0.423508549513812 no 1954 0.449594619683125 2706 688787 SGTC_288 1315-0019 35.1 µM -0.127056590641708 0.423373317190551 no 1955 0.449447804290897 2678 6811474 SGTC_1650 st011916 45.8 µM -0.12753343034771 0.423199511895466 no 1956 0.449259107803789 2651 242528 SGTC_3075 9116269 49.47 µM -0.128779000136895 0.422745579551758 no 1957 0.448766261306191 2779 17015205 YNL244C SUI1 SGTC_1773 st048542 73.5835 µM -0.129045207152944 0.4226485770136 no 1958 0.448660938860005 2625 3237138 SGTC_1279 0874-0590 65.2 µM -0.130063717860008 0.422277487684424 no 1959 0.448258007593384 2704 3523074 SGTC_520 3584-0023 682 µM -0.131481927200832 0.42176088510616 no 1960 0.447697041229606 2724 1340790 SGTC_1971 st069429 63.5 µM -0.132006260624667 0.421569923364138 no 1961 0.44748966991237 2706 1246522 YGL099W LSG1 SGTC_37 0566-0070 1.56 µM -0.133321590805723 0.421090962605861 no 1962 0.44696952651448 2755 1626686 SGTC_1523 st012844 44.7 µM -0.136141906478515 0.420064374967032 no 1963 0.445854549668529 2778 4274103 SGTC_3225 9130819 49.47 µM -0.136899219736756 0.419788807187143 no 1964 0.445555227794998 2659 4547121 SGTC_1811 st050069 61.5 µM -0.139847211625824 0.418716480702654 no 1965 0.444390355152615 2656 3877702 SGTC_2771 fluoxetine 41.05 µM -0.139944386453425 0.418681143776837 no 1966 0.444351965508 2807 3386 A selective serotonin reuptake inhibitor. SGTC_2606 farnesol 9.78 µM -0.140491440266878 0.418482223852194 no 1967 0.444135857547532 2774 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1488 4013-0813 75.9 µM -0.141233426116569 0.418212455981959 no 1968 0.443842770251225 2656 2910057 SGTC_409 arachidonic acid 100 µM -0.141433510461861 0.418139716798161 no 1969 0.443763741407629 2655 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_106 0092-0003 11.579 µM -0.142016587988479 0.41792775925292 no 1970 0.443533451584921 2765 1072148 SGTC_410 α-linolenic acid 100 µM -0.142416129023477 0.417782533771894 no 1971 0.443375661560505 2774 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_719 2810-4230 27.3 µM -0.144377011880657 0.417069953470256 no 1972 0.442601384235996 2647 721079 SGTC_1202 1988-0068 29.6 µM -0.144955220671963 0.416859885617708 no 1973 0.442373113504211 2673 2850480 SGTC_3052 9092717 49.47 µM -0.145446046071855 0.416681583470421 no 1974 0.442179355823753 2822 25237534 SGTC_2837 9008476 45.46 µM -0.145830026177069 0.416542106961549 no 1975 0.442027785911745 2858 2992805 SGTC_710 3448-4187 58 µM -0.145837799517098 0.416539283490556 no 1976 0.442024717599553 2678 3946412 SGTC_209 4077-0173 175.592 µM -0.147106987080093 0.416078340760189 no 1977 0.441523787494396 2754 15993494 SGTC_2123 5259487 200 µM -0.150383967972772 0.414888744094506 no 1978 0.440230844566305 2776 2173474 SGTC_1010 4112-3296 15.2 µM -0.151147222976467 0.414611781872004 no 1979 0.439929790913299 2820 704384 SGTC_169 k015-0017 16.025 µM -0.15147701080435 0.414492124938757 no 1980 0.439799722146512 2752 1840002 SGTC_157 1348-1695 65.819 µM -0.153495949029374 0.413759766863392 no 1981 0.439003592329971 2681 5380510 SGTC_532 1548-0774 215 µM -0.154672590923533 0.413333085011874 no 1982 0.438539719594656 2892 5932993 SGTC_2226 7298446 200 µM -0.15590299783263 0.412887015986797 no 1983 0.43805474113845 2729 3283010 SGTC_864 0469-0573 172 µM -0.156635488507667 0.412621513787416 no 1984 0.437766065985611 2672 689425 SGTC_2324 6149169 200 µM -0.156879817226733 0.412532962073776 no 1985 0.437669783203223 2761 2888231 SGTC_96 0929-0093 37.281 µM -0.159818685339981 0.411468182310486 no 1986 0.43651195225213 2674 6991579 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.161539850662173 0.410844889900919 no 1987 0.435834113598063 2669 2346 DNA damaging agent; causes G2/M arrest. SGTC_1126 isoteolin 1.0172 µM -0.162299968736139 0.410569696880284 no 1988 0.435534819649366 2701 133323 SGTC_254 nsc-64875 3.808 µM -0.163211493555589 0.410239746644684 no 1989 0.435175958500372 2838 56993 SGTC_2871 9038510 12.99 µM -0.163938318171074 0.409976698989365 no 1990 0.43488985081143 2710 4945164 SGTC_1747 st037496 66.6 µM -0.165280555546327 0.409491031692539 no 1991 0.434361581378068 2714 723305 SGTC_1613 st002381 52.1 µM -0.16638977951702 0.409089781360334 no 1992 0.433925108302929 2709 551167 SGTC_1483 3453-0561 55.9 µM -0.166533243865154 0.409037891558797 no 1993 0.43386866180175 2798 4546991 SGTC_1928 4'-methoxychalcone 40.3 µM -0.166905054938332 0.408903418162529 no 1994 0.433722377839265 2929 641818 SGTC_529 4076-0302 30.3 µM -0.166992462828814 0.40887180679266 no 1995 0.433687989721836 2720 5816522 SGTC_413 propylparaben 100 µM -0.168433285575994 0.408350813761347 no 1996 0.433121212023591 2695 7175 A pharmaceutical preservative. SGTC_621 3584-0052 32.1 µM -0.168484174174695 0.408332415699103 no 1997 0.433101196439008 2715 2273927 SGTC_1119 parthenolide 318.541 nM -0.170023094367018 0.40777613622245 no 1998 0.432495987198547 2903 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1665 st014639 11.4 µM -0.170085218745273 0.407753683777275 no 1999 0.432471558936687 2728 981133 YIL048W NEO1 SGTC_406 estrone 100 µM -0.170569596424383 0.407578634661815 no 2000 0.43228110303595 2871 5870 A steroid. SGTC_2312 7706453 155.7 µM -0.172881515052921 0.406743385821054 no 2001 0.431372280857918 2752 976098 SGTC_1025 k007-0731 70 µM -0.172964757849464 0.40671331979022 no 2002 0.431339564609171 2720 6256118 SGTC_3165 9101544 49.47 µM -0.173139399827129 0.406650243553741 no 2003 0.43127092800431 2820 5002184 SGTC_2402 5553605 200 µM -0.17347577122936 0.40652876159204 no 2004 0.431138735448483 2888 6758546 SGTC_2046 4110841 106 µM -0.17500181079716 0.405977739061369 no 2005 0.430539105366434 2805 44119630 YMR134W ERG29 SGTC_993 3909-8757 62.7 µM -0.175301472669591 0.405869558958612 no 2006 0.430421377333169 2762 4288324 YLR208W SEC13 SGTC_1401 3807-4679 7.6 µM -0.179172459453197 0.404472753700264 no 2007 0.428901143974725 2707 3291456 SGTC_2190 6049624 200 µM -0.179750769896174 0.40426418043091 no 2008 0.428674116954823 2706 2265554 SGTC_350 k064-0020 19.8 µM -0.180309880982342 0.404062557463447 no 2009 0.428454649451792 2903 2790705 SGTC_420 mitomycin C 81.9 mM -0.18070843120176 0.403918850454915 no 2010 0.428298220301436 2729 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2585 alliin 100 µM -0.183740539894093 0.40282597559774 no 2011 0.427108502032369 2911 87310 A garlic compound which reacts with lipids. SGTC_3297 9117502 71.43 µM -0.185671382372677 0.40213042934454 no 2012 0.426351235808218 2720 7453720 SGTC_2089 5281248 129.67 µM -0.185821051445943 0.402076527051916 no 2013 0.42629254768853 2741 2737878 SGTC_2655 perillic acid 100 µM -0.186071972220122 0.40198616383077 no 2014 0.426194160493851 2728 5702197 An apoptosis inducer. SGTC_335 4077-0256 27.6 µM -0.186190430183192 0.401943505798838 no 2015 0.42614771417512 2836 3121989 SGTC_760 0568-0725 82.9 µM -0.186908804182562 0.401684836359118 no 2016 0.425866068054883 2892 3916171 SGTC_2351 9026858 72.31 µM -0.187336323124569 0.401530917362208 no 2017 0.425698472673764 2733 1409300 SGTC_519 k048-0011 62.8 µM -0.190673971113906 0.400329795958262 no 2018 0.424390516285055 2861 6836379 SGTC_3336 9143619 71.43 µM -0.190947769071638 0.400231305777967 no 2019 0.424283257172091 2731 45595730 SGTC_932 2857-0803 154 µM -0.19109807400151 0.40017724101686 no 2020 0.424224378278458 2970 674898 SGTC_367 0335-0881 7.1 µM -0.191952729275941 0.39986985746641 no 2021 0.423889616674816 2889 23828853 SGTC_3010 9080089 71.4286 µM -0.193439498906785 0.399335276902668 no 2022 0.42330739195235 2857 17027233 SGTC_31 0508-1974 57.237 µM -0.194718409381365 0.398875584779736 no 2023 0.422806699580774 2823 6810525 SGTC_1125 tnp00248 1.32998 µM -0.194906498289816 0.398807989836216 no 2024 0.422733073428854 2926 24207736 SGTC_1367 1812-0510 76.9 µM -0.195870264554743 0.398461681472747 no 2025 0.422355855937512 2793 1142582 YDR527W RBA50 SGTC_2109 5483026 200 µM -0.195950156252253 0.398432977720283 no 2026 0.422324589570057 2782 759335 SGTC_1374 2889-5571 141 µM -0.196058874953781 0.398393917789482 no 2027 0.422282042269652 2821 2853281 SGTC_1859 st055998 20 µM -0.19638577422148 0.398276477130635 no 2028 0.422154114994988 2785 676301 SGTC_3151 9099821 49.47 µM -0.196397210659526 0.398272368683653 no 2029 0.42214963965987 2882 17174189 SGTC_212 3807-4682 38.772 µM -0.196520546383569 0.398228062048585 no 2030 0.422101376259282 2826 3125501 YBL034C STU1 SGTC_1696 st025591 34.7925 µM -0.196826362088518 0.398118207692222 no 2031 0.421981710335918 2771 2787147 SGTC_1885 st057546 99.9 µM -0.196922694346586 0.398083605130373 no 2032 0.421944016939645 2906 702008 SGTC_1084 voriconazole 435 nM -0.196956765931953 0.398071366803561 no 2033 0.421930685400379 2784 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3020 9089140 49.47 µM -0.197112579691734 0.398015400632722 no 2034 0.421869719690001 2831 17217859 SGTC_1891 st059073 26.2 µM -0.197444260661001 0.397896272355135 no 2035 0.421739948133649 2947 688754 SGTC_3287 9117173 37.0625 µM -0.197779831089968 0.397775756805811 no 2036 0.421608663458429 2789 2789709 SGTC_1809 st050081 57.6 µM -0.197880897142856 0.397739462220168 no 2037 0.421569125256895 2904 5036894 SGTC_1447 4239-0816 81.9 µM -0.199038303727413 0.397323880472764 no 2038 0.421116390972422 2761 1341554 SGTC_535 2293-4129 48.2 µM -0.200454298246658 0.396815607930336 no 2039 0.42056264862713 2908 396118 YIL048W NEO1 SGTC_1149 3909-7961 23.3 µM -0.201019841853428 0.396612654455116 no 2040 0.420341529592926 2765 735261 SGTC_394 menadione 8.33 µM -0.201309017747902 0.396508890334988 no 2041 0.420228475880847 2773 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2289 7946404 165.07 µM -0.203551116032826 0.39570461416974 no 2042 0.419352148502532 2779 1246120 YPR165W RHO1 SGTC_1336 1486-0901 104 µM -0.203623847411253 0.395678531687479 no 2043 0.419323728010316 2846 5006114 SGTC_85 0868-0259 160.055 µM -0.203952426166761 0.395560704607454 no 2044 0.419195337919735 2834 83173 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.204516093309174 0.395358597972537 no 2045 0.418975108561232 2841 688761 SGTC_2334 9017922 200 µM -0.205365604861904 0.395054053090346 no 2046 0.418643245438611 2925 3163164 SGTC_339 3091-4833 71.4 µM -0.207115302824685 0.394426998852386 no 2047 0.417959905642198 2784 3240077 SGTC_605 1315-0399 119 µM -0.207406980840158 0.394322494256002 no 2048 0.417846015606916 2885 24020461 SGTC_3085 9117376 49.47 µM -0.208479141801107 0.393938417774406 no 2049 0.417427433634341 2852 16480349 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.208828243929343 0.393813382376548 no 2050 0.417291160966305 2842 75037 A free radical scavenger. SGTC_1826 st055655 41.6 µM -0.210660598430853 0.393157280939522 no 2051 0.416576061244768 2833 676168 SGTC_1521 st012942 49.4 µM -0.211934935685788 0.392701164501214 no 2052 0.416078897443721 3014 24207259 SGTC_3129 9127257 49.47 µM -0.213584048209741 0.392111125585542 no 2053 0.415435720020956 2812 837894 SGTC_3022 9087993 49.47 µM -0.214180061114983 0.391897938003581 no 2054 0.415203322116971 2798 17173644 SGTC_2183 6420625 130.508 µM -0.214547031350538 0.391766692726618 no 2055 0.415060247493129 2768 2897619 SGTC_1007 4101-0031 70 µM -0.214854042598045 0.391656900977576 no 2056 0.414940558376483 2963 1146276 SGTC_1030 k029-0042 36.7 µM -0.216304444265151 0.391138332769307 no 2057 0.414375222522162 2846 6080581 SGTC_592 k241-0073 46.5 µM -0.216333970763913 0.39112777804231 no 2058 0.414363715556172 2901 4230158 SGTC_402 epigallocatechin gallate 10 µM -0.216991030075868 0.390892922268261 no 2059 0.414107667685588 2814 65064 An antioxidant. SGTC_1130 3454-2858 15.9 µM -0.217697545933306 0.390640433405265 no 2060 0.413832387943618 2896 715628 YIL048W NEO1 SGTC_2133 5320837 200 µM -0.218414207066406 0.390384366008251 no 2061 0.413553198551885 2947 2841355 SGTC_140 0062-0056 502.533 µM -0.218591400956259 0.390321060876384 no 2062 0.413484175931412 2751 3758964 SGTC_2681 menadione 3.18 µM -0.219924623263092 0.389844840896544 no 2063 0.41296492957981 2854 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2893 9048488 25.97 µM -0.220316451022864 0.389704913485426 no 2064 0.412812354425444 2818 6467338 SGTC_865 0488-0499 301 µM -0.221844022917718 0.389159531925977 no 2065 0.412217653938407 2783 9634651 SGTC_3222 9128301 49.47 µM -0.22226778462183 0.38900827697957 no 2066 0.412052714506671 2827 4911358 SGTC_2159 5658611 73.75 µM -0.223532503531103 0.38855695593489 no 2067 0.411560544432136 2822 793844 SGTC_1874 staurosporine 7.6 µM -0.223792720262809 0.388464114974964 no 2068 0.411459297353824 2928 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3207 9114163 49.47 µM -0.224899667005842 0.388069246230704 no 2069 0.411028664175523 3077 849233 SGTC_2063 5246145 200 µM -0.227301047208319 0.387213026924664 no 2070 0.410094829431982 2928 711240 SGTC_1404 3909-7820 48.3 µM -0.229615497343428 0.386388321708364 no 2071 0.409195281733426 2897 23741373 SGTC_244 nsc-207895 1.295 µM -0.229713354796912 0.386353463557211 no 2072 0.409157258383011 2764 42640 SGTC_1846 st056244 14.8 µM -0.230292964514764 0.386147017533853 no 2073 0.408932063605939 2876 5393182 SGTC_115 0527-0192 112.043 µM -0.230814336195561 0.38596134233303 no 2074 0.408729521630847 2887 4233931 SGTC_95 0471-0001 561.058 µM -0.231616918119513 0.38567557127703 no 2075 0.408417783022162 2838 4015405 SGTC_1334 1486-0610 236 µM -0.232189761977549 0.385471639761731 no 2076 0.40819531462533 2909 3742339 SGTC_3283 9109332 35.8195 µM -0.232584571150052 0.385331106741296 no 2077 0.40804200461179 2788 17027281 SGTC_393 acivicin 6.25 µM -0.233822373838978 0.384890606370343 no 2078 0.407561439590998 2819 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.234078828991323 0.384799359500584 no 2079 0.40746189070631 2950 521171 SGTC_442 cape 100 µM -0.234652275982591 0.384595349869196 no 2080 0.407239315878501 2955 5281787 SGTC_3089 9117425 49.47 µM -0.236246780082112 0.384028256849002 no 2081 0.40662059070831 2885 9401657 SGTC_2818 7996756 12.99 µM -0.236596766954815 0.38390381551964 no 2082 0.406484814299261 2773 2241621 SGTC_1900 st060200 72.8 µM -0.241738654039348 0.382076952266392 no 2083 0.40449133803646 2810 688945 SGTC_1416 3966-0321 25.3 µM -0.243669400900041 0.381391651400093 no 2084 0.403743436839487 2896 582530 YLR208W SEC13 SGTC_3278 9139605 49.47 µM -0.244022263167259 0.381266446290065 no 2085 0.40360678875837 3038 7958859 SGTC_1458 k015-0034 6.33 µM -0.244786916615232 0.380995169149216 no 2086 0.403310712407228 2893 3598957 SGTC_960 1222-0186 7.7 µM -0.244802081842496 0.380989789551954 no 2087 0.403304840940797 2950 3126296 SGTC_1713 st033146 12.748 µM -0.245798732362234 0.380636295811566 no 2088 0.402919019196798 2977 674619 SGTC_1112 tnp00069 1.16933 µM -0.245821040182852 0.380628384773825 no 2089 0.402910384509186 2945 145826 SGTC_2194 5927483 104.545 µM -0.245885922735928 0.380605375713211 no 2090 0.402885270690015 2831 760979 SGTC_1590 st077108 57.8 µM -0.246105131460429 0.380527641655564 no 2091 0.402800425447472 2937 5489485 SGTC_550 4123-0385 25.7 µM -0.246212705339255 0.380489496424867 no 2092 0.402758790403484 2845 5731123 SGTC_2387 9077560 195.08 µM -0.246457411885998 0.380402728873725 no 2093 0.402664084086029 2842 5303272 SGTC_1779 st039427 55 µM -0.246765445156121 0.380293515615998 no 2094 0.402544877183299 3032 1124498 SGTC_1132 3456-3614 2.5 µM -0.247582723947541 0.380003795523732 no 2095 0.402228639465829 3112 3125502 SGTC_75 0159-0059 199.013 µM -0.248925648839081 0.379527883531864 no 2096 0.401709147370331 3152 5377270 SGTC_640 3381-0960 37.1 µM -0.248974909883957 0.379510429637813 no 2097 0.401690094706036 2897 1745025 SGTC_3211 9128781 49.47 µM -0.249825728279052 0.379209011260577 no 2098 0.401361061102827 2978 17194361 SGTC_2216 7189485 200 µM -0.249976060918991 0.379155760729913 no 2099 0.401302930824146 2961 731273 SGTC_3156 9099931 49.47 µM -0.251167822857363 0.378733698389103 no 2100 0.400842180466005 2829 18111053 SGTC_1851 st056236 18.9 µM -0.251352485350861 0.378668313114767 no 2101 0.400770799915355 2992 5393171 SGTC_1446 4239-0190 62 µM -0.257253681393115 0.376580656571512 no 2102 0.398491473129703 2875 1340085 SGTC_1512 0259-0544 12.2 µM -0.258319317642133 0.376204050621378 no 2103 0.398080239374762 2874 18476 SGTC_1982 st072467 71.9 µM -0.258570862084561 0.376115169610044 no 2104 0.397983183754835 2813 3163533 SGTC_1610 st001799 48.1 µM -0.260763445179658 0.375340718414754 no 2105 0.39713746793917 2831 621897 SGTC_226 1,3-diallylurea 8.28947 mM -0.260789506648075 0.375331516151238 no 2106 0.397127418496279 2958 74537 YKL182W FAS1 SGTC_2727 riluzole 51.77 µM -0.261727274633234 0.375000438991864 no 2107 0.396765855595031 2865 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2588 indole-3-carbinol 100 µM -0.261938564179369 0.374925856332101 no 2108 0.396684403693923 3009 3712 Induces cell cycle arrest. SGTC_2595 hexamethylquercetagetin 100 µM -0.263908215965454 0.374230818391333 no 2109 0.395925322300335 2952 386331 SGTC_1055 3448-0672 86 µM -0.264183852244145 0.374133586188454 no 2110 0.395819126615497 3011 748378 SGTC_1312 1218-2183 165 µM -0.264429448279257 0.374046957590572 no 2111 0.395724511190828 2858 6744073 SGTC_840 0245-0196 390 µM -0.267055360030685 0.373121123378424 no 2112 0.394713268605977 3018 3827528 SGTC_327 1273-0057 3.96 µM -0.268355059081485 0.372663150849219 no 2113 0.394213014401035 2921 3108138 SGTC_486 niguldipine 82 µM -0.270666610904116 0.371849078641849 no 2114 0.393323729571035 2867 1236 A calcium channel blocker. SGTC_1741 st038134 10.228 µM -0.271971386728435 0.371389820989696 no 2115 0.392822010208603 3122 1272587 SGTC_1547 harmine 94.2 µM -0.272179217756554 0.371316685084275 no 2116 0.39274211032749 2911 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1328 1441-0025 69.2 µM -0.273092897841567 0.370995215474538 no 2117 0.392390903002569 2865 4562601 SGTC_1509 1326-1131 80 µM -0.273212043361967 0.370953301890605 no 2118 0.392345111390275 2990 768313 SGTC_3068 9116768 49.47 µM -0.274666021517541 0.37044193794278 no 2119 0.391786419174916 3000 41904888 SGTC_1001 4048-4355 44.4 µM -0.276012736313269 0.369968502618608 no 2120 0.391269141959303 2895 21824233 SGTC_3294 9122953 26.2835 µM -0.279568749353523 0.368719340687936 no 2121 0.389904192888839 2876 16459826 SGTC_217 ketoconazole 989 nM -0.280082341610109 0.368539039401501 no 2122 0.389707166048619 2977 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.282694422614563 0.367622492963233 no 2123 0.388705546020209 2902 1241132 A phosphatase inhibitor. SGTC_2111 5486399 200 µM -0.284020968704479 0.367157312729133 no 2124 0.388197155686487 2921 689674 SGTC_2555 cholic acid 100 µM -0.284554533765763 0.36697026227518 no 2125 0.387992724237146 3062 6708657 Influences liver metabolism. SGTC_718 1130-0073 349 µM -0.285454769749628 0.366654740594101 no 2126 0.387647875960225 3075 6740020 SGTC_2802 7925815 54.55 µM -0.285575147527783 0.36661255648183 no 2127 0.387601770240269 2893 1262923 SGTC_1558 st069300 45.6 µM -0.285856870509349 0.36651383829757 no 2128 0.38749387412181 3019 24208000 SGTC_1835 st008666 49.2 µM -0.286114823598217 0.366423457034892 no 2129 0.387395089172899 2910 690455 SGTC_2438 5259590 200 µM -0.286423211088161 0.366315414355921 no 2130 0.387276999583984 3001 1201127 SGTC_2434 5670830 169.91 µM -0.288285620866795 0.365663149893214 no 2131 0.386564056520693 3014 1549830 SGTC_584 0986-0246 15.4 µM -0.289395925656584 0.365274476787886 no 2132 0.386139206265729 2922 53315 YDR232W HEM1 SGTC_1780 st038448 24.544 µM -0.290266915738099 0.364969674950111 no 2133 0.385806023594792 3097 728868 YDL195W SEC31 SGTC_2793 7325131 81.82 µM -0.290396775429264 0.364924238024168 no 2134 0.38575635515363 2984 4176441 SGTC_1657 st012939 43.4 µM -0.290453404980806 0.364904424365335 no 2135 0.385734696197193 3073 24207257 SGTC_2044 5102272 200 µM -0.292734231814107 0.364106704584504 no 2136 0.384862651140235 3007 592666 SGTC_3186 9110464 49.47 µM -0.295257605985362 0.363224839490023 no 2137 0.383898549556861 3047 17018021 SGTC_3197 9113331 49.47 µM -0.29879331624841 0.361990404308576 no 2138 0.382548875489355 3167 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_54 0159-0055 9 µM -0.299937731190885 0.361591157251258 no 2139 0.382112326597932 3167 3319099 SGTC_1845 st056753 3.01 µM -0.300510918878208 0.361391248349656 no 2140 0.381893734517436 2875 5375839 SGTC_2932 9016711 44.54 µM -0.300545988221135 0.361379018550891 no 2141 0.381880361619471 3068 7117328 SGTC_2987 9018338 71.43 µM -0.300695105401204 0.361327018214401 no 2142 0.381823500741351 3002 5055682 SGTC_925 2064-1272 59.6 µM -0.301620383893938 0.361004411199442 no 2143 0.381470733591827 2945 6815817 SGTC_3218 9131285 49.47 µM -0.30184888125141 0.360924758666269 no 2144 0.381383632953181 3115 17156417 SGTC_1267 0828-0272 9.49 µM -0.302127603183842 0.360827606373833 no 2145 0.38127739540137 3075 745334 SGTC_622 1348-1566 26.3 µM -0.303018834419105 0.360517015986083 no 2146 0.380937754095678 3022 7340407 SGTC_1260 0700-1617 7.75 µM -0.304432666059862 0.360024490336711 no 2147 0.380399142074768 3059 2853078 SGTC_1418 3966-3099 2.4 µM -0.305032571826234 0.359815575924716 no 2148 0.380170672498621 3036 740335 SGTC_2782 7736369 71.43 µM -0.305544577888651 0.359637305297427 no 2149 0.379975711922274 2997 2950836 YOL077C BRX1 SGTC_1732 st034308 51.822 µM -0.30630155816001 0.359373795340037 no 2150 0.379687526478514 2858 830119 SGTC_168 3970-0862 530.542 µM -0.306420789807299 0.359332296088866 no 2151 0.379642140596012 3032 3135186 SGTC_1714 st033236 13.627 µM -0.308147959695886 0.358731331149913 no 2152 0.378984874498097 3140 2916566 SGTC_2345 9052315 157.45 µM -0.312842665205052 0.357099588982299 no 2153 0.37720009950357 3044 6469265 SGTC_2860 9025725 38.96 µM -0.313203587846709 0.356974250518262 no 2154 0.377062996380013 2916 40546248 SGTC_737 1950-0117 57.9 µM -0.313279495758875 0.356947891761254 no 2155 0.377034163331173 3096 5393513 SGTC_484 loperamide 105 µM -0.313916495658684 0.35672672269495 no 2156 0.376792230749702 2940 3955 An opioid-receptor agonist. SGTC_1889 st059080 5.18 µM -0.315275688908247 0.356254966121994 no 2157 0.376276170949482 3131 176925 Isolated from Daphnopsis sellowiana. SGTC_2317 5986382 200 µM -0.316052072439969 0.355985593120179 no 2158 0.375981492063493 3033 877883 SGTC_2850 9015429 58.44 µM -0.317054947698336 0.355637743246309 no 2159 0.375600954543918 3025 6457570 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.31713454115174 0.355610141195662 no 2160 0.375570758262834 2978 2724278 An inhibitor of dopamine biosynthesis. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.318563375564404 0.355114767558429 no 2161 0.375028814788555 3023 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_603 3794-0023 45.9 µM -0.320009910971 0.354613506352632 no 2162 0.374480408722084 3076 3802260 SGTC_664 1222-0054 14.9 µM -0.320183255512911 0.354553454941436 no 2163 0.374414707880162 2988 6813991 SGTC_2544 sphondin 68.51 µM -0.320813195053178 0.354335256664845 no 2164 0.37417597966192 3165 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2696 st077691 74.316 µM -0.322671829509725 0.353691742244375 no 2165 0.373471894336578 3130 757133 SGTC_1921 5740136 50 µM -0.323038507762095 0.35356483664156 no 2166 0.373333039576016 3165 1774243 SGTC_1228 0124-0032 52.5 µM -0.323272754508136 0.353483773472946 no 2167 0.373244342962116 3052 X1228 SGTC_819 1013-0258 27.7 µM -0.324777823368393 0.352963089668432 no 2168 0.372674614925146 2992 5753198 SGTC_2298 7976326 193.81 µM -0.32516527709045 0.352829093213133 no 2169 0.372527993397961 2951 2235818 SGTC_3069 9117009 49.47 µM -0.325257356516703 0.352797251276505 no 2170 0.372493151110722 3032 41904981 SGTC_2376 9072922 81.32 µM -0.325727143592426 0.352634810516296 no 2171 0.372315402826153 3096 17087968 SGTC_601 0986-0029 62.9 µM -0.326263394893447 0.35244942090804 no 2172 0.372112540430618 2995 24747981 SGTC_985 1493-0307 8.71 µM -0.329889935781719 0.351196596682855 no 2173 0.37074156415056 3132 3278274 SGTC_482 fipronil 114 µM -0.329978717882386 0.351165946236018 no 2174 0.370708021486013 3030 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2836 9010338 19.48 µM -0.330026856619919 0.351149327594773 no 2175 0.370689834655135 2979 2994051 SGTC_2648 atorvastatin 78.68 µM -0.331257859139208 0.350724452930106 no 2176 0.370224859767582 3081 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1068 loratadine 26.9 µM -0.335978145380682 0.349097002478845 no 2177 0.368443673476173 3039 3957 A H1 histamine antagonist. SGTC_2265 7929201 200 µM -0.336306873911091 0.348983767027545 no 2178 0.368319733443145 2944 1265108 SGTC_3059 1327-0034 3 µM -0.337222348477251 0.348668489037126 no 2179 0.367974645664155 3003 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1623 st003709 20.3 µM -0.337293120243935 0.348644120474058 no 2180 0.367947972706708 2987 16192618 SGTC_914 3820-6779 408 µM -0.337311201333991 0.348637894783841 no 2181 0.367941158281382 2956 2893481 SGTC_172 1112-0046 2.638 µM -0.337733605609152 0.348492463929824 no 2182 0.367781973825892 3015 2802135 YIL048W NEO1 SGTC_778 3456-2434 196 µM -0.33882928727725 0.348115332186962 no 2183 0.367369168452716 3127 5539063 SGTC_2795 7780010 54.55 µM -0.340655249903167 0.347487172776364 no 2184 0.366681565524169 3146 953673 SGTC_2248 tofa 1.1 µM -0.340865604960053 0.347414834237109 no 2185 0.366602379526918 2943 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_509 pifithrin 175 µM -0.34278714407019 0.346754297891832 no 2186 0.365879299097827 3099 4817 A p53 inhibitor. SGTC_1487 3970-0795 2.82 µM -0.344523288218648 0.34615789200386 no 2187 0.365226392666305 3109 3765103 SGTC_218 alverine citrate 93.75 µM -0.346269624102775 0.345558369696901 no 2188 0.364570047321735 3152 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_502 l-744,832 89.3 µM -0.346695050092849 0.345412378280299 no 2189 0.364410214652339 3117 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_559 1550-0661 158 µM -0.349747435240511 0.344365581284669 no 2190 0.3632641255003 3094 5830875 SGTC_1793 st048256 72.231 µM -0.351118143340127 0.343895892270202 no 2191 0.362749858506106 3009 672022 SGTC_2729 fluphenazine 10.66 µM -0.352145839207612 0.343543898275875 no 2192 0.36236444628985 3011 3372 An atypical antipsychotic. SGTC_2858 9025781 8.96 µM -0.35349461429267 0.343082137940282 no 2193 0.361858832832348 3108 4894980 YPL153C RAD53 SGTC_669 0108-0021 26.2 µM -0.353567334766641 0.343057248347453 no 2194 0.361831579048746 3331 17201 SGTC_3056 9094900 49.47 µM -0.35365821603555 0.343026143927428 no 2195 0.36179752004631 3058 25236784 SGTC_363 0455-0021 3.06 µM -0.354863113318706 0.3426138643857 no 2196 0.361346071816004 3005 4597466 SGTC_107 0358-0022 2.6945 µM -0.354959793241626 0.342580791545424 no 2197 0.361309856353987 3109 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_665 3914-0008 307 µM -0.355959539266318 0.342238863309458 no 2198 0.360935433076793 3023 1069549 SGTC_2448 5185112 27.17 µM -0.357349035522316 0.341763849382804 no 2199 0.360415262489166 3160 5718189 SGTC_581 0958-0271 211 µM -0.358126311508817 0.341498238577809 no 2200 0.360124394707437 3034 4591145 SGTC_2281 7943571 200 µM -0.359551848907553 0.341011307862113 no 2201 0.359591148740678 3261 1244024 SGTC_2528 xanthyletin 44.79 µM -0.359915635247527 0.340887089194946 no 2202 0.359455112136675 3020 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1686 st019653 115.5 µM -0.361584418389635 0.340317486880292 no 2203 0.358831305116919 3171 97252 SGTC_65 0798-0905 34.986 µM -0.36230654834775 0.34007111654768 no 2204 0.358561482626058 3416 3602145 SGTC_1309 pyrazolanthrone 13.4 µM -0.36311152384885 0.33979656212984 no 2205 0.358260788256775 3153 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2711 st079103 59.1 µM -0.363794160134168 0.339563800734038 no 2206 0.358005861912274 3087 54693780 SGTC_1658 st012944 20 µM -0.365076968136674 0.339126561800941 no 2207 0.357526976439057 3126 24207260 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.365394437194737 0.339018387409001 no 2208 0.357408496546565 3063 65057 A dermal irritant. YDR527W RBA50 SGTC_1945 st075991 56.6 µM -0.365613223131525 0.33894384602312 no 2209 0.357326853330179 3077 1084980 SGTC_964 1287-0107 19.4 µM -0.365880097172685 0.338852929333458 no 2210 0.357227274166206 3206 51516812 YPR165W RHO1 SGTC_971 1315-0384 26.7 µM -0.366389119014908 0.338679545537955 no 2211 0.357037368945467 3063 6769120 SGTC_1395 3486-0190 4.35 µM -0.366837345250985 0.338526898334108 no 2212 0.356870174592701 3220 6748079 SGTC_2592 piperlongumine 83.33 µM -0.368903832882121 0.33782348203151 no 2213 0.356099703161118 3124 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2667 digitoxin 100 µM -0.369864712539272 0.33749659870827 no 2214 0.355741647576892 3138 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1412 3909-8563 178 µM -0.370222191000858 0.337375018761618 no 2215 0.355608471718669 3170 23767530 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.371103923085103 0.337075210529476 no 2216 0.355280064572328 3079 6857784 SGTC_2968 9090663 33.37 µM -0.371342443528268 0.336994126122353 no 2217 0.355191244455867 3092 25236811 SGTC_3277 9138724 49.47 µM -0.37139822195558 0.336975165482924 no 2218 0.355170474849369 3087 15943418 SGTC_2411 st077133 39.94 µM -0.372175887695345 0.336710858424761 no 2219 0.354880948754849 3326 1403142 YNL221C POP1 SGTC_2749 bexarotene 57.39 µM -0.372219792738091 0.336695938719608 no 2220 0.354864605340354 3127 82146 An retinoic acid receptor inhibitor. SGTC_1209 2323-2347 50.3 µM -0.373082093320899 0.336402965948318 no 2221 0.354543672785592 3158 5412760 SGTC_2127 5253358 187.912 µM -0.373210039408325 0.336359503809032 no 2222 0.354496062374583 2991 20612 SGTC_2297 7971671 152.32 µM -0.373704950377512 0.336191407580531 no 2223 0.354311920946375 3238 909016 SGTC_3131 9127911 49.47 µM -0.375687611318437 0.335518326584611 no 2224 0.353574574538829 3291 45595681 SGTC_1901 st060216 58.6 µM -0.376084954477043 0.335383498456598 no 2225 0.35342686961894 3039 688792 SGTC_1255 0566-0045 221 µM -0.376996594467977 0.335074237133116 no 2226 0.353088067869969 3211 2788469 SGTC_2482 5981709 142.65 µM -0.379391196220597 0.334262434290561 no 2227 0.35219869358578 3092 877755 SGTC_777 1315-0167 517 µM -0.382869026633114 0.333084782185119 no 2228 0.35090843892571 3140 4221767 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.382964105686894 0.333052609848799 no 2229 0.350873189204906 3174 5357218 A potent inhibitor of glutathione S-transferases. SGTC_791 1348-1292 225 µM -0.383826478319598 0.33276086099642 no 2230 0.350553530803128 3116 5437054 SGTC_2028 5153890 36.43 µM -0.385048880095223 0.332347484354102 no 2231 0.350100600562185 3085 2830968 YPR165W RHO1 SGTC_448 monastrol 171 µM -0.389170247096066 0.330955276389188 no 2232 0.348575105691702 3131 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_64 000l-0018 272.079 µM -0.389451953338699 0.330860200345389 no 2233 0.348470923132958 3020 6811119 SGTC_1799 st045822 46.1415 µM -0.390668600787491 0.330449706384134 no 2234 0.348021105488137 3226 3674992 SGTC_949 1165-0505 146 µM -0.392733898835184 0.329753346791648 no 2235 0.347258015312611 3092 6244267 SGTC_2365 9042475 200 µM -0.394606552123336 0.329122451160585 no 2236 0.346566638634873 3210 6464479 SGTC_1088 bifonazole 369 nM -0.395351251916748 0.328871697364203 no 2237 0.346291840037523 3180 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2034 5197015 53.07 µM -0.395557376644221 0.328802305068463 no 2238 0.346215793091022 3244 780676 SGTC_1252 0493-0875 34.8 µM -0.398331955771359 0.327868812722152 no 2239 0.345192753965241 3085 3960963 SGTC_868 0527-0199 213 µM -0.399659041958332 0.327422701142017 no 2240 0.344703831615931 3129 2849450 SGTC_1233 0325-0408 14.2 µM -0.400280529238708 0.32721386743062 no 2241 0.344474953645041 3214 12874 SGTC_1466 k213-0079 57.5 µM -0.404857226722609 0.325677663083091 no 2242 0.342791230415408 3124 3657981 SGTC_3063 1327-0034 4 µM -0.405253632434951 0.32554474512719 no 2243 0.342645542797851 3201 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_227 fluconazole 33.516 µM -0.405590987126549 0.325431644913395 no 2244 0.342521576131168 3158 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1323 1348-1351 11.2 µM -0.406597520564062 0.325094294007211 no 2245 0.342151809298083 3127 6989654 SGTC_2964 9083345 53.42 µM -0.40707860381053 0.324933104198771 no 2246 0.341975128769401 3154 17741579 SGTC_1615 st002656 86.5 µM -0.407858167822992 0.324671976209644 no 2247 0.341688902969923 3208 1584458 SGTC_2906 7926292 26.41 µM -0.40815549248851 0.324572405034044 no 2248 0.341579760797265 3234 2966319 SGTC_3111 9122088 49.47 µM -0.409078532403417 0.324263367735035 no 2249 0.341241014993701 3132 16876704 SGTC_3263 9137018 49.47 µM -0.409258358483902 0.324203175353472 no 2250 0.341175035616828 3178 43844957 SGTC_1230 0170-0365 3.77 µM -0.411025411459992 0.323611942194619 no 2251 0.340526950767337 3263 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2788 5282734 71.43 µM -0.411403348690773 0.323485546977075 no 2252 0.340388399425744 3273 743706 SGTC_2177 5811945 192 µM -0.413164184791727 0.322896931441233 no 2253 0.339743163233046 3267 5343475 SGTC_2702 st077768 96.8 µM -0.41332205966618 0.322844178373186 no 2254 0.339685334873072 3202 6484119 SGTC_1171 0368-0077 21.4 µM -0.413477922039742 0.322792101268386 no 2255 0.339628247378305 3106 3239779 SGTC_1941 st076221 61.8 µM -0.413576444432436 0.32275918452605 no 2256 0.339592163616229 3223 2828568 SGTC_2989 9073649 71.4286 µM -0.41367383231354 0.322726648193571 no 2257 0.339556496813242 3256 21367202 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.414265169975571 0.322529117246773 no 2258 0.339339959414455 3352 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3193 9111931 49.47 µM -0.414866731018125 0.322328222662094 no 2259 0.33911973281698 3112 17087244 SGTC_2853 9015042 58.44 µM -0.4169133360328 0.321645136564013 no 2260 0.338370899310278 3030 6457456 SGTC_875 0709-0210 25.7 µM -0.417191742193966 0.321552260704804 no 2261 0.338269082409194 3266 6251364 SGTC_3285 9112818 20.8695 µM -0.41771248714407 0.321378570949175 no 2262 0.338078670683272 3135 17017947 YPR165W RHO1 SGTC_834 0312-0008 75.7 µM -0.417759706573945 0.321362823267147 no 2263 0.338061406824962 3161 6385573 YIL048W NEO1 SGTC_1597 7-benzyloxygramine 47.5 µM -0.417980925619852 0.32128905098176 no 2264 0.337980531640539 3142 260807 SGTC_839 0122-0028 230 µM -0.420144462592807 0.320567925167123 no 2265 0.337189961656452 3142 759448 SGTC_2093 5331342 194.4 µM -0.420162672693811 0.320561858449457 no 2266 0.337183310615364 3266 33839 SGTC_758 0868-0029 16 µM -0.420627807841677 0.320406914353939 no 2267 0.337013442323287 3244 762687 SGTC_319 1348-1596 45.5 µM -0.423655830319396 0.319398996854833 no 2268 0.335908416113486 3306 5380505 SGTC_1299 1079-1439 3.74 µM -0.426772834046384 0.318362852845607 no 2269 0.334772397486109 3171 323161 SGTC_127 0180-0333 59.125 µM -0.42716656796267 0.318232069927761 no 2270 0.334629005041321 3230 771601 SGTC_1555 citronellol 128 µM -0.427295213686804 0.318189343788679 no 2271 0.334582159274389 3226 8842 A terpine precursor. SGTC_2948 9070189 9.45 µM -0.427968567445903 0.317965747334837 no 2272 0.334337002531959 3255 6473636 YDL196W YDL196W SGTC_688 0527-0193 473 µM -0.430300096062275 0.317192043897656 no 2273 0.333488678619891 3168 4007154 SGTC_52 0329-0193 875 nM -0.431763806168264 0.316706728363395 no 2274 0.332956543850837 3337 3739292 SGTC_2228 7354201 200 µM -0.434015187690997 0.315960863965534 no 2275 0.332138706111895 3202 753451 SGTC_1008 4106-0037 6 µM -0.434317782666632 0.315860673711264 no 2276 0.332028846159729 3085 2905394 SGTC_1627 st003713 25.6 µM -0.43499579757592 0.315636229722916 no 2277 0.331782738897442 3233 16195070 YER133W GLC7 SGTC_726 3448-4391 34.2 µM -0.43584449478994 0.315355380402475 no 2278 0.331474779306862 3363 1356692 SGTC_2088 5278280 127.392 µM -0.438352525508939 0.314526051259541 no 2279 0.330565377661137 3267 791502 SGTC_2054 5233173 129 µM -0.438988615199051 0.3143158643039 no 2280 0.330334892820235 3291 6889 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.439578183396102 0.314121103470435 no 2281 0.330121322338758 3145 442882 SGTC_236 1509-0011 5.31 µM -0.442391704192449 0.313192384821869 no 2282 0.329102890539727 3341 3107280 SGTC_2012 4023501 200 µM -0.442926934616502 0.313015843761039 no 2283 0.328909292282281 3221 3477460 SGTC_1207 2099-0101 141 µM -0.443747731352685 0.312745194431165 no 2284 0.328612490965804 3273 5837381 SGTC_346 4513-0042 7.16 µM -0.444857787494025 0.312379325324216 no 2285 0.328211264979521 3152 2827372 SGTC_1039 k821-0043 94 µM -0.447129027738742 0.311631312022322 no 2286 0.327390950679625 3299 15992768 SGTC_1269 0831-0796 3.05 µM -0.447256495745612 0.311589354527316 no 2287 0.327344937117135 3303 927758 SGTC_620 0109-0052 432 µM -0.447335825518975 0.311563243495705 no 2288 0.327316301879363 3333 493037 SGTC_1644 st010134 20.9 µM -0.447536143108921 0.311497314095994 no 2289 0.327243998848983 3301 3818134 SGTC_2001 4023502 57.655 µM -0.448496730533663 0.311181245379673 no 2290 0.326897372612779 3257 108941 YCR052W RSC6 SGTC_3029 9088683 49.47 µM -0.448697278906021 0.311115275117623 no 2291 0.326825023925749 3306 25236615 SGTC_2122 5258151 111.688 µM -0.450259178405462 0.31060169703681 no 2292 0.326261784934511 3196 2173356 SGTC_435 c-PAF 6.7 µM -0.452470445694946 0.309875227191392 no 2293 0.325465053802279 3286 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2172 5754775 163.918 µM -0.453213499472037 0.309631277362833 no 2294 0.325197506349851 3172 2263357 SGTC_695 3505-6186 243 µM -0.453274831363414 0.309611145411846 no 2295 0.325175426922444 3291 1819379 SGTC_2770 toltrazuril 17.5 µM -0.453436444135631 0.309558099393779 no 2296 0.32511724940524 3311 68591 Kills coccidiodes. SGTC_3281 9140613 49.47 µM -0.455001472901088 0.309044616730573 no 2297 0.324554089597643 3240 16013766 SGTC_1467 k284-1082 293 µM -0.456649550160216 0.308504289084341 no 2298 0.32396147899983 3280 3334705 SGTC_3324 9138759 60.749 µM -0.457448891436106 0.308242371552603 no 2299 0.323674214775652 3318 45595710 SGTC_438 sphingosine 6.67 µM -0.458132917578334 0.308018316438957 no 2300 0.323428475447665 3153 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_648 0375-0473 33.3 µM -0.459513606740808 0.30756628495003 no 2301 0.322932691591578 3213 1713139 SGTC_1236 0330-0013 258 µM -0.459534129460475 0.307559568104022 no 2302 0.322925324574226 3209 4617066 SGTC_305 1682-2595 20.8 µM -0.460219850723293 0.307335176662537 no 2303 0.322679211950529 3278 226033 SGTC_885 0865-0106 16.8 µM -0.460765672391528 0.30715661668269 no 2304 0.322483366276295 3192 2793380 SGTC_2207 7258803 200 µM -0.463138720491273 0.306380830128134 no 2305 0.321632468591338 3297 3666799 SGTC_1817 st052116 64.4 µM -0.463362693734647 0.306307654499038 no 2306 0.321552207300185 3332 4361398 SGTC_476 mead acid 10 µM -0.465003723812335 0.305771739615234 no 2307 0.320964394945131 3216 5312531 An omega 9 fatty acid. SGTC_2485 5633444 17.78 µM -0.467250908340507 0.305038545964351 no 2308 0.32016018741692 3270 5724239 SGTC_170 4197-0004 226 µM -0.467362396972073 0.305002190667816 no 2309 0.320120310551599 3334 218692 SGTC_2307 7538926 6.34 µM -0.467389936270322 0.304993210682185 no 2310 0.320110460711337 3249 96582 SGTC_1700 st030840 7.9285 µM -0.467900253290403 0.304826828295354 no 2311 0.319927961175149 3311 5499307 SGTC_928 2764-0428 58.7 µM -0.468543768034134 0.304617076008941 no 2312 0.31969788959783 3305 662578 SGTC_2619 obliquin 87.91 µM -0.46873860998864 0.304553580344252 no 2313 0.31962824271644 3229 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2741 miltefosine 3.04 µM -0.468902978478299 0.304500020040523 no 2314 0.319569493618842 3217 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_632 0781-2353 4.65 µM -0.46926959455012 0.304380571442327 no 2315 0.319438472874426 3315 6811515 YHR007C ERG11 SGTC_1397 3532-0190 20.1 µM -0.469549024066482 0.304289543443403 no 2316 0.319338625876095 3147 5322280 SGTC_385 1494-0393 12.4 µM -0.471127063253699 0.303775703247059 no 2317 0.318774999948278 3249 3090647 SGTC_894 0960-0238 55.9 µM -0.471622756922984 0.303614375708501 no 2318 0.318598040174565 3348 6741907 YDL195W SEC31 SGTC_1289 0976-0073 69.1 µM -0.472578541829668 0.303303415770128 no 2319 0.318256947292924 3327 3391136 SGTC_3042 9091578 49.47 µM -0.47280871671372 0.303228550773224 no 2320 0.318174827323737 3317 25236497 SGTC_2716 st080858 38.6235 µM -0.473146546508243 0.303118685693441 no 2321 0.31805431527406 3343 5296050 SGTC_1226 3909-7979 35.4 µM -0.474716918939203 0.302608221336276 no 2322 0.317494378524092 3335 6615510 SGTC_2383 9036125 200 µM -0.474973706612763 0.302524786743501 no 2323 0.317402857199604 3215 79580 SGTC_2569 tetrandrine 100 µM -0.475139009538213 0.30247108252585 no 2324 0.317343947727365 3223 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3018 9082602 49.47 µM -0.475859950378842 0.302236910626344 no 2325 0.31708707810392 3352 17332089 SGTC_858 0438-0351 2.77 µM -0.47615290353113 0.302141778503218 no 2326 0.316982724714819 3277 2799119 SGTC_1361 1608-0041 5.61 µM -0.477197734325287 0.301802594962225 no 2327 0.316610662165441 3250 X1361 SGTC_191 3914-0123 66.505 µM -0.477717366998199 0.301633970297159 no 2328 0.316425690849243 3207 3144412 SGTC_2875 9039966 71.43 µM -0.477738128294251 0.301627233982659 no 2329 0.316418301497184 3275 6463691 SGTC_3271 9137798 49.47 µM -0.478861985956301 0.301262682493791 no 2330 0.316018407965402 3313 6498326 SGTC_1434 4073-0095 163 µM -0.478906266089907 0.301248323183189 no 2331 0.316002656512815 3335 24133745 SGTC_2367 9070478 135.38 µM -0.479260645058035 0.30113341508729 no 2332 0.315876607873847 3288 572802 SGTC_1398 3558-0053 112 µM -0.480812693235665 0.300630393159426 no 2333 0.315324814016198 3173 4532369 SGTC_1258 0671-0043 57.1 µM -0.482002575138818 0.300245007116929 no 2334 0.31490205847023 3290 4298767 SGTC_2685 mycophenolic acid 18.85 µM -0.48353906461316 0.29974769042632 no 2335 0.314356514673029 3274 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2442 5158906 48.48 µM -0.483558960258758 0.299741253235162 no 2336 0.314349453208032 3344 1893835 SGTC_2350 9023895 38.85 µM -0.483807725180571 0.299660771193109 no 2337 0.314261166016728 3364 2997209 SGTC_1173 0443-0020 122 µM -0.484721168706582 0.299365332023649 no 2338 0.313937074166088 3253 5331295 SGTC_3008 9078912 71.4286 µM -0.487192274623108 0.298566753926242 no 2339 0.313061039753725 3268 16648731 SGTC_1075 aripiprazole 15.2 µM -0.487686005733198 0.298407312890289 no 2340 0.312886132814119 3272 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2518 prenyletin 46.28 µM -0.489820019270381 0.297718620091443 no 2341 0.312130631633681 3326 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1277 0873-0036 22 µM -0.490402713602715 0.297530698009038 no 2342 0.311924478424172 3358 5965735 SGTC_3150 9097574 49.47 µM -0.491617212262004 0.297139189776333 no 2343 0.311494986614057 3367 17217476 SGTC_1429 4049-0205 9.46 µM -0.491785611750091 0.297084922776675 no 2344 0.311435454530388 3345 22774478 SGTC_2218 6965428 192.983 µM -0.492863669587148 0.296737624370344 no 2345 0.311054459604782 3341 675684 SGTC_2287 7945887 168.79 µM -0.49375964155566 0.296449126798943 no 2346 0.3107379693742 3316 1245853 SGTC_1293 1000-1278 195 µM -0.49420836567421 0.296304688668416 no 2347 0.310579516119603 3394 678847 SGTC_1990 st072050 59.8 µM -0.495092775111223 0.296020103941773 no 2348 0.310267316756443 3255 17233948 SGTC_2537 larixol 68.93 µM -0.496590817979312 0.295538351089862 no 2349 0.309738814733384 3372 6708759 SGTC_2933 9026794 32.47 µM -0.497615727599918 0.295208960127571 no 2350 0.309377458121749 3269 17586027 SGTC_2382 9035899 200 µM -0.498250252749107 0.295005117767664 no 2351 0.309153833299845 3275 6462679 SGTC_79 0052-0007 94.094 µM -0.498534962364387 0.29491367536506 no 2352 0.309053516453973 3415 2801472 SGTC_2957 9076800 11.52 µM -0.498686024938196 0.294865162727255 no 2353 0.309000295648461 3272 16459615 SGTC_790 1575-0012 79.1 µM -0.498775185953446 0.294836531047331 no 2354 0.308968885242017 3390 378741 YLR208W SEC13 SGTC_2810 7959871 45.46 µM -0.499013952396897 0.294759863889686 no 2355 0.308884777432756 3319 2974535 SGTC_546 peri-Naphthalide 147 µM -0.499155080579049 0.294714552394955 no 2356 0.308835068365334 3273 223824 A penicillin ester. SGTC_2075 5212009 200 µM -0.500797090026703 0.294187594866387 no 2357 0.308256966908952 3364 780898 SGTC_1699 st031318 29.054 µM -0.501752713801799 0.293881114377712 no 2358 0.307920739592067 3363 5340658 SGTC_2902 5787006 60.46 µM -0.501779077483761 0.293872661309051 no 2359 0.307911466059896 3231 591003 SGTC_508 roscovitine 141 µM -0.50395872770337 0.293174182688805 no 2360 0.307145190038952 3349 160355 A CDKinase inhibitor. SGTC_947 3447-0010 211 µM -0.504276463757709 0.293072427074412 no 2361 0.307033557205993 3365 748350 SGTC_1871 st057448 67.3 µM -0.504489305599041 0.293004273207649 no 2362 0.306958787726081 3483 691747 SGTC_2096 5468907 200 µM -0.504650515226761 0.29295265733328 no 2363 0.306902161534761 3349 759785 SGTC_1764 st044502 93.5 µM -0.505389903239631 0.292715975180629 no 2364 0.306642504522021 3389 8407 SGTC_2069 5228469 200 µM -0.505784099366396 0.292589827146445 no 2365 0.306504111043281 3358 2835210 SGTC_2013 4024628 200 µM -0.50589247393339 0.292555150262477 no 2366 0.306466067981611 3414 5230760 SGTC_659 k018-0002 107 µM -0.508715355072957 0.291652579354278 no 2367 0.305475878903928 3403 6797879 YHR007C ERG11 SGTC_3087 9117406 49.47 µM -0.508753378195647 0.29164043093598 no 2368 0.305462551123573 3374 42546093 SGTC_219 mitoxanthrone 164.414 µM -0.509664806207621 0.291349299575967 no 2369 0.305143156595152 3348 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2669 eugenol 100 µM -0.510169343649307 0.291188196889663 no 2370 0.304966413754267 3346 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_973 1325-0077 65.9 µM -0.510460966448586 0.291095098458673 no 2371 0.304864277079062 3327 2835149 SGTC_3251 9135047 49.47 µM -0.511905304130239 0.290634209352916 no 2372 0.304358642897057 3356 17682963 SGTC_761 k216-0224 480 µM -0.51217505382318 0.290548169893548 no 2373 0.304264250233088 3461 1340404 SGTC_510 ag-490 170 µM -0.512826135344312 0.290340549814209 no 2374 0.304036473050244 3446 5328779 SGTC_2331 7980721 200 µM -0.512985500197793 0.290289741351255 no 2375 0.30398073174009 3304 2981221 SGTC_301 4119-0100 24.5 µM -0.513368888846265 0.290167527021571 no 2376 0.303846651923551 3330 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2292 7671323 168.05 µM -0.514093990151802 0.289936449524739 no 2377 0.303593139499581 3412 937504 SGTC_698 k064-0052 127 µM -0.514098680220427 0.28993495516028 no 2378 0.303591500049023 3418 5088751 SGTC_2164 5685496 200 µM -0.514189113761651 0.289906141646386 no 2379 0.303559889062878 3409 759046 SGTC_2315 7733312 200 µM -0.516361112684759 0.289214513260311 no 2380 0.302801110272217 3274 726316 SGTC_2073 5212005 126 µM -0.517139370598783 0.288966881930703 no 2381 0.302529435945562 3310 691789 SGTC_2515 chrysin 20.77 µM -0.519621377477739 0.288177807437597 no 2382 0.301663747647954 3366 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2783 7738165 71.43 µM -0.520310268360084 0.287958977033608 no 2383 0.301423670070313 3305 17201110 SGTC_1656 st012921 11 µM -0.520475091923418 0.287906631453251 no 2384 0.301366242024681 3364 6732821 SGTC_959 1222-0044 107 µM -0.521320113017895 0.287638335566323 no 2385 0.301071896044169 3403 6083612 SGTC_1728 st035614 33.7865 µM -0.524917987074664 0.28649732805213 no 2386 0.29982010240267 3345 15945546 SGTC_655 k060-0012 42 µM -0.525588274703776 0.286284994725229 no 2387 0.299587152610772 3309 5994525 SGTC_1319 1306-0155 43.7 µM -0.526032652558032 0.286144266167027 no 2388 0.299432760064247 3371 3122360 SGTC_1832 st054113 55 µM -0.530160693342758 0.284838543620408 no 2389 0.298000260572302 3417 1251267 SGTC_599 1935-0052 86.5 µM -0.531635531468055 0.284372734245954 no 2390 0.297489225349995 3303 9557311 SGTC_736 0958-0254 92.6 µM -0.532983380893983 0.283947351289254 no 2391 0.297022542307501 3450 6812352 SGTC_2025 5147754 141 µM -0.535203074164027 0.283247477712073 no 2392 0.296254720387785 3380 315777 YLR208W SEC13 SGTC_2137 5261020 140 µM -0.536046394206773 0.282981794341156 no 2393 0.295963243402178 3358 763655 SGTC_569 4130-2812 160 µM -0.537164051752912 0.282629866896206 no 2394 0.29557715006573 3370 743552 SGTC_566 0958-0068 16.5 µM -0.537360169521067 0.282568135133776 no 2395 0.295509425328053 3434 6815365 SGTC_1278 0874-0585 172 µM -0.538140558337754 0.282322557285479 no 2396 0.295240006809872 3388 766306 SGTC_1106 tegaserod maleate 11.7 µM -0.538143073718045 0.282321765895238 no 2397 0.295239138592215 3371 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.538572172290856 0.282186778305073 no 2398 0.295091046598146 3474 23847180 SGTC_1932 st074806 40.9 µM -0.541087027445659 0.281396270062227 no 2399 0.294223799647285 3547 17251235 SGTC_2428 5615643 7.78 µM -0.541112482721851 0.281388274031874 no 2400 0.294215027426217 3407 2253075 SGTC_1432 4049-0298 68.4 µM -0.541248865357772 0.281345435284178 no 2401 0.294168030244335 3429 741646 SGTC_2601 securinine 100 µM -0.541579826844638 0.281241491037627 no 2402 0.294053996006953 3303 442872 A GABA receptor antagonist. SGTC_283 0987-0079 11.7 µM -0.542245804200929 0.281032385408288 no 2403 0.293824592527013 3445 411556 SGTC_1557 sumaresinolic acid 42.3 µM -0.54234008537874 0.281002788783696 no 2404 0.293792122993535 3367 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2899 9053889 58.44 µM -0.542795047547603 0.280859988826283 no 2405 0.293635461725082 3430 6470052 SGTC_2488 5268135 45.7 µM -0.54630425624772 0.279759726390885 no 2406 0.292428405510722 3420 1270356 YLR208W SEC13 SGTC_1086 cerivastatin 2.18 µM -0.54697159239111 0.279550729542038 no 2407 0.292199124396046 3420 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1870 st057514 26.5 µM -0.549099943100222 0.278884677890359 no 2408 0.291468432142614 3347 5393161 SGTC_3265 9137266 49.47 µM -0.549880100209319 0.278640727012595 no 2409 0.2912008070405 3400 17224265 SGTC_2106 5357045 167.29 µM -0.550003654996823 0.27860210163714 no 2410 0.291158433330906 3406 668842 SGTC_2395 5646831 180.19 µM -0.552614225525807 0.277786602046533 no 2411 0.290263799447964 3478 6808628 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.55349344848672 0.277512209776553 no 2412 0.289962782764633 3366 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3352 9151559 45.5865 µM -0.553660521338083 0.277460083831892 no 2413 0.289905599133989 3377 17159339 SGTC_1785 bathophenanthroline 24 µM -0.554291362042764 0.277263307657971 no 2414 0.289689730474464 3341 72812 An iron chelator. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.55469149962967 0.277138529376782 no 2415 0.2895528456953 3358 6708630 An antioxidant. SGTC_1504 k297-0033 30 µM -0.555850010852872 0.276777416059651 no 2416 0.289156696992127 3274 4388117 SGTC_24 0417-1663 219 µM -0.55653000481046 0.276565566198113 no 2417 0.288924294278066 3450 4329390 SGTC_2531 methyl deoxycholate 70.07 µM -0.558100311215716 0.276076646386858 no 2418 0.288387944057021 3338 16667744 Haematoxylin. SGTC_1369 1866-0067 208 µM -0.558154886933147 0.276059661700001 no 2419 0.288369311744488 3484 3531355 SGTC_733 4069-0007 56.1 µM -0.558614633064824 0.275916602976824 no 2420 0.28821237557795 3480 5717425 YNL287W SEC21 SGTC_1583 clindamycin 39.6 µM -0.558622442018401 0.275914173387467 no 2421 0.288209710308654 3375 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2676 harmalol 100 µM -0.558676201161265 0.275897447661946 no 2422 0.288191362123154 3468 5459187 A monoamine oxidase inhibitor SGTC_1196 1588-0294 184 µM -0.559315348310359 0.275698632220422 no 2423 0.287973261173995 3421 6144269 SGTC_672 1441-0018 53.7 µM -0.559486450285429 0.275645420569078 no 2424 0.287914887995786 3374 251141 SGTC_524 r073-0010 27.8 µM -0.559591489901611 0.275612756402499 no 2425 0.287879055430925 3384 2772106 SGTC_1790 st045711 43.5 µM -0.559841338796758 0.275535068546747 no 2426 0.287793831987933 3513 585119 SGTC_1251 0490-5699 265 µM -0.560247775259935 0.275408714466842 no 2427 0.287655222003243 3522 3883818 SGTC_1191 1487-1166 10.6 µM -0.560892581531207 0.275208313838859 no 2428 0.287435383783832 3472 3955771 SGTC_345 1362-0200 395 µM -0.561780494525488 0.274932475134873 no 2429 0.28713279163703 3389 1419823 SGTC_1896 st058441 89 µM -0.562822704572358 0.274608876466727 no 2430 0.286777809072629 3384 688759 SGTC_3047 9092122 49.47 µM -0.563250104836479 0.274476226123024 no 2431 0.286632294327009 3405 17173831 SGTC_2854 9024559 71.43 µM -0.564371508100851 0.274128331507484 no 2432 0.286250662548557 3423 3163529 SGTC_677 0929-0063 136 µM -0.566722019698792 0.27339983632616 no 2433 0.285451529042025 3434 1539583 SGTC_315 k915-0449 187 µM -0.569099899245724 0.272663835697812 no 2434 0.28464417337297 3454 20970215 YNL149C PGA2 SGTC_2187 6125751 200 µM -0.571083664807086 0.272050574404873 no 2435 0.283971465510848 3447 874498 SGTC_542 3381-0244 89.3 µM -0.572296937867849 0.271675841472215 no 2436 0.283560411951501 3514 1112843 SGTC_686 1319-0111 510 µM -0.572677518285768 0.271558347926757 no 2437 0.283431531124901 3537 4562600 SGTC_1621 st003705 32.4 µM -0.574746951804951 0.270919911522055 no 2438 0.282731224223632 3510 24207032 SGTC_2121 5257820 149.641 µM -0.574889470723517 0.270875970904482 no 2439 0.282683025707691 3517 791256 SGTC_471 1-acyl-paf 4 µM -0.575152297840493 0.270794946880115 no 2440 0.282594150482464 3407 16759367 SGTC_3234 9132280 49.47 µM -0.577384039531748 0.270107436156271 no 2441 0.281840026781532 3491 17612295 SGTC_774 k060-0086 136 µM -0.57830527139736 0.269823896139075 no 2442 0.281529018052603 3521 5911235 SGTC_2135 5326629 150.42 µM -0.578407265777909 0.269792513111616 no 2443 0.281494594837345 3421 5020077 SGTC_1340 1486-1359 257 µM -0.578815003128206 0.269667073162092 no 2444 0.281357003322591 3392 4309068 SGTC_1825 st052143 62.6 µM -0.581375398115549 0.268880038806995 no 2445 0.280493737312692 3528 674173 SGTC_1970 st070122 35.8 µM -0.584527758035738 0.267912628456352 no 2446 0.279432647743557 3564 102928 SGTC_2115 tiliquinol 12.7705 µM -0.584711577917193 0.267856271123374 no 2447 0.279370833874306 3431 71208 A bioactive hydroxyquinoline. SGTC_2746 daunorubicin 9.88 µM -0.584884589351595 0.267803233007727 no 2448 0.279312660675109 3404 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2032 5185112 25.99 µM -0.585331136880287 0.267666364549065 no 2449 0.279162541167019 3406 5718189 SGTC_87 0100-0052 35.5 µM -0.58668514009524 0.267251573222191 no 2450 0.278707594828201 3557 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1047 2043-3044 82 µM -0.589619095552442 0.26635388671333 no 2451 0.277723023297483 3447 669592 SGTC_2700 st077718 96.8 µM -0.591262048268763 0.265851868622047 no 2452 0.2771724270938 3460 904970 SGTC_2624 nerol 100 µM -0.591340358979991 0.26582795210047 no 2453 0.277146196477205 3466 637566 A natural product oil. SGTC_1563 conessine 56.1 µM -0.592363780404802 0.265515493853211 no 2454 0.276803507373368 3555 441082 An anti-amoebic, histamine inhibitor. SGTC_1622 st003707 19.4 µM -0.59288814869645 0.265355472493678 no 2455 0.276628004928 3511 10140899 SGTC_2465 5809242 33.21 µM -0.593396715301606 0.265200320103564 no 2456 0.276457843310264 3491 2731748 SGTC_2938 9059746 27.26 µM -0.594590196420342 0.264836396473732 no 2457 0.276058717396218 3478 6471769 SGTC_147 4466-0538 29.23 µM -0.594884295455791 0.264746756982706 no 2458 0.275960407781286 3593 6742687 YHR072W ERG7 SGTC_1275 0867-0008 21.1 µM -0.59661533374167 0.264219460486621 no 2459 0.275382115661723 3433 3422836 SGTC_1402 3909-7673 35.9 µM -0.597060319988028 0.26408399842981 no 2460 0.275233554440067 3496 5328014 SGTC_938 3126-1755 342 µM -0.597077992249469 0.26407861939666 no 2461 0.275227655268444 3530 1777771 SGTC_1909 st060837 51.5 µM -0.597669280082207 0.263898677057303 no 2462 0.275030313566797 3430 678937 SGTC_1609 st001574 46.4 µM -0.597869703767872 0.263837697757095 no 2463 0.274963438190161 3424 3960012 SGTC_3090 9117696 49.47 µM -0.598530016909646 0.263636847023298 no 2464 0.274743168183153 3435 7923821 SGTC_1519 esterone 74 µM -0.598641711329428 0.263602880090929 no 2465 0.274705917298421 3435 698 A steroid. SGTC_2755 lomerizine 42.69 µM -0.599741403228969 0.263268576548508 no 2466 0.274339295240843 3492 3949 A calcium channel blocker. SGTC_946 3434-1334 87.4 µM -0.60103333227785 0.262876110207087 no 2467 0.273908892794054 3489 4047976 SGTC_134 0269-0018 6.916 µM -0.605032022215974 0.261663274179244 no 2468 0.272578859959012 3453 4378915 SGTC_2564 betulinic acid 100 µM -0.605097927439226 0.261643308655668 no 2469 0.272556965636582 3584 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_443 clozapine 122 µM -0.605194694327492 0.261613995224612 no 2470 0.272524820366801 3466 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1101 ebselen 5.29 µM -0.605510476508222 0.261518347585297 no 2471 0.272419932875711 3582 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1182 1222-0449 220 µM -0.605722513417868 0.261454133550189 no 2472 0.272349515773856 3491 658318 SGTC_527 4476-4215 268 µM -0.612813773646528 0.259311263130475 no 2473 0.269999741226992 3427 4418754 SGTC_1708 st033234 31.827 µM -0.613438617711254 0.259122880805489 no 2474 0.269793178999065 3582 674664 SGTC_1035 k081-0041 55.2 µM -0.61562512572203 0.25846423462647 no 2475 0.269070982207149 3583 731709 SGTC_377 3970-0964 33.1 µM -0.615736709284964 0.258430645359393 no 2476 0.269034152538857 3542 16481235 SGTC_1948 st076329 66.6 µM -0.616921382485847 0.258074170471035 no 2477 0.268643291178576 3471 24208413 SGTC_1748 st037455 53.6035 µM -0.61742309010802 0.257923280699743 no 2478 0.268477847934528 3554 580690 SGTC_376 3970-0862 59.1 µM -0.618776075695278 0.257516595305397 no 2479 0.268031942522821 3536 3135186 SGTC_565 1418-0001 44.5 µM -0.620432305980742 0.25701921331057 no 2480 0.267486604348117 3580 2862145 SGTC_1552 6-methylflavone 10.6 µM -0.621512975636922 0.256694947357446 no 2481 0.267131079868496 3530 689013 SGTC_3293 9120939 62.045 µM -0.621584892924809 0.256673375403457 no 2482 0.267107428603372 3559 934087 SGTC_2766 oltipraz 83.91 µM -0.621639491929308 0.256656998786466 no 2483 0.267089473466373 3552 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1243 0416-0003 5.65 µM -0.622315707422305 0.256454217446116 no 2484 0.266867147373766 3502 2141977 SGTC_2724 maprotiline 69.64 µM -0.622828558791298 0.256300480897106 no 2485 0.266698594497929 3556 4011 A tricyclic antidepressant. SGTC_3109 9122853 49.47 µM -0.623820645701642 0.256003221160317 no 2486 0.266372689677612 3552 1234709 SGTC_3081 9117243 49.47 µM -0.624785900076217 0.255714174001717 no 2487 0.266055792987509 3586 45595589 SGTC_762 1165-0429 115 µM -0.625049450539171 0.255635282966324 no 2488 0.265969301562647 3557 5967793 SGTC_3073 9114972 49.47 µM -0.625682877819381 0.255445725229352 no 2489 0.265761483034174 3504 41905075 SGTC_386 1509-0011 3.07 µM -0.62613930601502 0.255309181303668 no 2490 0.265611786444746 3589 3107280 SGTC_933 2914-0560 114 µM -0.628488589652586 0.254606979477679 no 2491 0.26484195956479 3583 463887 SGTC_499 genistein 192 µM -0.631388347097879 0.25374163776589 no 2492 0.263893316707994 3570 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2405 ticlatone 3.52 µM -0.631398467031526 0.253738620495355 no 2493 0.263890009052075 3455 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1373 2887-0003 58.5 µM -0.631774828576356 0.253626421222624 no 2494 0.263767011942809 3535 776948 SGTC_2759 disulfiram 3.38 µM -0.632805306158736 0.253319353114355 no 2495 0.263430395637574 3529 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.633306282364606 0.25317013974896 no 2496 0.263266825766039 3509 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2580 diallyl disulphide 81.36 µM -0.63356092609676 0.253094313055016 no 2497 0.263183703896453 3558 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_38 0929-0051 58.268 µM -0.634482083549744 0.252820114634509 no 2498 0.262883127848986 3556 1379719 SGTC_3028 9087778 49.47 µM -0.634971686170512 0.252674439637066 no 2499 0.262723440723404 3508 17217395 SGTC_3323 9138564 53.9225 µM -0.635312814271024 0.25257296747096 no 2500 0.262612208881046 3593 43912313 YNL103W MET4 SGTC_884 0851-0618 334 µM -0.635482742597983 0.252522428502221 no 2501 0.262556809244141 3579 9642473 SGTC_2014 4013930 200 µM -0.63612158730188 0.252332475179934 no 2502 0.262348588110986 3559 64556 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.636902589137685 0.252100355399755 no 2503 0.262094148090361 3548 5379071 SGTC_1410 3909-8106 77.9 µM -0.639223555552676 0.251411211553362 no 2504 0.261338755177937 3594 1039210 SGTC_3270 9137563 49.47 µM -0.639454450112921 0.251342708586998 no 2505 0.261263668328028 3517 17015724 SGTC_1142 3253-1408 9.78 µM -0.641058667650725 0.250867033777788 no 2506 0.260742283410488 3578 256655 SGTC_455 paf C-16 10 µM -0.642082022850277 0.250563842593767 no 2507 0.260409963827095 3557 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2245 6637752 200 µM -0.642456467935349 0.250452953643805 no 2508 0.260288422818096 3544 681890 SGTC_2916 7875993 68.79 µM -0.642963429022036 0.250302862580818 no 2509 0.260123915069978 3582 1299250 SGTC_2363 9053361 176 µM -0.646183793133112 0.249350555224863 no 2510 0.259080167075939 3641 6469797 YMR079W SEC14 SGTC_496 calpeptin 138 µM -0.646648474061733 0.249213301666677 no 2511 0.258929738928019 3553 73364 A calpain inhibitor. SGTC_3168 9103419 49.47 µM -0.647675514047859 0.248910085793189 no 2512 0.258597422283801 3544 16649256 SGTC_2384 9036245 200 µM -0.655725870515628 0.246540173921791 no 2513 0.256000260078829 3590 6462766 SGTC_1089 terbinafine 2.25 µM -0.6557523861977 0.246532388101135 no 2514 0.255991728274225 3599 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1733 st037357 54.9 µM -0.655766031544521 0.246528381458516 no 2515 0.25598733774414 3573 1272339 YGL099W LSG1 SGTC_903 1134-0042 114 µM -0.655986828072983 0.246463554479851 no 2516 0.255916299661264 3589 701009 SGTC_2079 5212404 121 µM -0.658257566243762 0.245797384614681 no 2517 0.255186319909314 3617 758462 SGTC_2481 5478948 45.16 µM -0.658542824966686 0.245713766229776 no 2518 0.255094694133789 3620 77792 SGTC_3300 9124615 50.48 µM -0.65961670666643 0.245399114453123 no 2519 0.254749915182579 3644 24824903 SGTC_2441 5730946 39.09 µM -0.660052139126987 0.245271592670647 no 2520 0.254610185400577 3628 1774275 SGTC_2130 NSC 7 2.4545 µM -0.660136119311307 0.245247002133422 no 2521 0.254583240873307 3597 21448 SGTC_2329 6138490 200 µM -0.660261812288761 0.245210200001164 no 2522 0.254542915842994 3599 720019 SGTC_444 curcumin 90.4 µM -0.660440602811813 0.245157856349846 no 2523 0.254485561735321 3590 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3210 9128157 49.47 µM -0.660508325702441 0.245138031010325 no 2524 0.25446383871703 3565 17590849 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.660832914449959 0.245043022197444 no 2525 0.25435973604752 3453 4000243 SGTC_1433 4060-0023 7.6 µM -0.661038520573523 0.244982850465818 no 2526 0.254293805243279 3625 3840627 SGTC_1493 4348-0038 111 µM -0.661105403225847 0.244963278613629 no 2527 0.254272360210998 3644 800424 SGTC_1018 4259-0013 28.1 µM -0.662137973696109 0.244661224583198 no 2528 0.253941400586664 3608 6801262 SGTC_2751 anetholtrithion 17.25 µM -0.664037490921699 0.244106090056987 no 2529 0.253333158024545 3597 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_181 1447-1644 8.07 µM -0.664196945316103 0.244059520383499 no 2530 0.253282134153683 3578 534600 SGTC_1306 1185-0270 9.02 µM -0.664271199096291 0.244037835728554 no 2531 0.253258375503002 3616 1548076 SGTC_1448 4255-0083 152 µM -0.665756737406331 0.243604225959314 no 2532 0.252783300776593 3656 5399660 SGTC_1141 3253-0389 52.6 µM -0.667127419232012 0.243204510687488 no 2533 0.252345373667293 3604 5402031 SGTC_364 0083-0097 67.7 µM -0.667938489458734 0.24296815522622 no 2534 0.252086428592662 3647 5207356 SGTC_2092 5303694 80.6725 µM -0.668990643150597 0.242661730433352 no 2535 0.251750723363542 3611 1963699 SGTC_230 MPP+ 141.667 µM -0.669500085228752 0.242513437889938 no 2536 0.251588263180456 3602 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_776 4476-4378 112 µM -0.671426877007885 0.241953015820299 no 2537 0.250974313881319 3622 2892008 SGTC_2863 9028737 58.44 µM -0.671511420074958 0.241928441923713 no 2538 0.250947393406792 3618 6460917 SGTC_1350 1495-0454 146 µM -0.673983898875874 0.2412103725805 no 2539 0.250160775117962 3653 1069057 SGTC_2507 purpurin 79.67 µM -0.674172126937392 0.241155753961019 no 2540 0.250100944041272 3622 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2806 7952793 58.44 µM -0.674179906335074 0.241153496737918 no 2541 0.250098471407882 3640 2972490 SGTC_3155 9099265 49.47 µM -0.674404391062361 0.241088366551401 no 2542 0.250027125913793 3591 25236499 SGTC_705 1124-0212 310 µM -0.674408753365157 0.241087101002821 no 2543 0.250025739598392 3633 9554485 SGTC_2876 9059903 25.97 µM -0.674490759476595 0.241063310864808 no 2544 0.249999679274407 3616 6916095 SGTC_1213 1315-0166 115 µM -0.674921481344719 0.240938378545288 no 2545 0.249862825932919 3602 768401 SGTC_2167 5876490 200 µM -0.676625800468659 0.240444380628226 no 2546 0.249321702525142 3683 686534 SGTC_3060 1327-0027 12.5 µM -0.677236884523382 0.240267391994884 no 2547 0.249127834439676 3564 16000455 YPR107C YTH1 SGTC_794 k038-0031 316 µM -0.677576781133485 0.240168978272335 no 2548 0.249020036026419 3674 6624242 SGTC_768 0384-0033 77.3 µM -0.679342184120591 0.239658176772922 no 2549 0.248460536866347 3638 3965305 YMR134W ERG29 SGTC_1241 0364-0022 50.8 µM -0.679866729418458 0.239506519234875 no 2550 0.248294424886253 3638 4563895 SGTC_2997 9067075 71.4286 µM -0.679963521146068 0.239478540353445 no 2551 0.248263779543245 3642 27209819 SGTC_1324 1418-0026 34.4 µM -0.680543339987622 0.239310973706707 no 2552 0.248080244649333 3675 1372513 SGTC_597 k018-0003 82.8 µM -0.680908461995213 0.239205486950399 no 2553 0.247964706687161 3723 6786234 SGTC_2239 6685329 187.64 µM -0.680952772963941 0.239192686875517 no 2554 0.247950687029529 3647 805680 SGTC_2094 5332512 191.667 µM -0.68259859894824 0.23871752363804 no 2555 0.247430259826433 3678 755774 SGTC_2257 7960413 200 µM -0.682940229635866 0.238618956870543 no 2556 0.247322305879327 3626 2974689 YIL048W NEO1 SGTC_2424 5537928 59.2 µM -0.682992470201219 0.238603886465537 no 2557 0.247305800286936 3700 5382802 SGTC_888 0916-0002 6.97 µM -0.683609212106744 0.23842600759215 no 2558 0.247110983011637 3692 2802138 YIL048W NEO1 SGTC_1325 1431-0015 227 µM -0.685848832944413 0.237780673797797 no 2559 0.24640421936862 3610 1103340 SGTC_195 4234-0266 16.654 µM -0.685926331159445 0.237758360297576 no 2560 0.246379782439337 3651 2303354 SGTC_2327 6189656 200 µM -0.686111553702255 0.237705035164482 no 2561 0.246321382870459 3693 5349088 SGTC_131 0141-0277 33.849 µM -0.691225933146017 0.236235212169791 no 2562 0.244711784568618 3622 1547771 SGTC_1502 4534-4282 27.7 µM -0.691867818159604 0.236051094815361 no 2563 0.244510171149249 3647 3278949 SGTC_1715 st032160 10.2275 µM -0.692187789838694 0.235959344147154 no 2564 0.244409702803235 3591 5289825 SGTC_32 0928-0142 34.1 µM -0.692452412150375 0.235883479551555 no 2565 0.244326630489808 3633 2244242 SGTC_2717 st081029 62.2815 µM -0.692570592452348 0.23584960277326 no 2566 0.244289535318149 3644 5292846 SGTC_2361 9034121 116 µM -0.694387166313124 0.235329213417444 no 2567 0.243719719929264 3670 6496917 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.694483914570941 0.235301515975681 no 2568 0.243689392473551 3691 165506 SGTC_2163 5671233 125 µM -0.69531147643509 0.235064672116813 no 2569 0.243430061817126 3709 701023 SGTC_1219 1469-0211 33.1 µM -0.695838995668403 0.234913767636775 no 2570 0.243264832496288 3638 6822282 SGTC_2982 9019404 25.97 µM -0.697932336224773 0.234315465459294 no 2571 0.242609755370194 3555 22333232 SGTC_359 0081-0058 15.9 µM -0.698452291970175 0.234166986654829 no 2572 0.242447191835149 3743 3494159 SGTC_2949 9072542 2.23 µM -0.69946303861744 0.233878506490787 no 2573 0.242131352033724 3707 16457352 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.699745971523268 0.233797789071955 no 2574 0.242042980666147 3689 165521 SGTC_3108 9121785 49.47 µM -0.701358031762334 0.233338182026131 no 2575 0.241539803086084 3618 17140271 SGTC_568 1193-0097 7.48 µM -0.705270355195044 0.232224845119968 no 2576 0.240321002629244 3582 3646150 SGTC_670 4204-0025 119 µM -0.705646694670538 0.232117905593301 no 2577 0.240203939050527 3703 719039 SGTC_2052 5265182 7.135 µM -0.705939878683842 0.232034614278882 no 2578 0.240112763221726 3677 1239884 SGTC_1651 st011928 86.1 µM -0.706411531369655 0.23190065631552 no 2579 0.239966125908877 3683 720198 SGTC_3119 9125183 49.47 µM -0.706438680188782 0.231892946867018 no 2580 0.239957686799299 3567 22695334 SGTC_1919 st067113 52.3 µM -0.707810587918732 0.231503552224702 no 2581 0.239531445184088 3694 1268243 SGTC_2522 biochanin a 4.94 µM -0.708064395405084 0.231431552901965 no 2582 0.239452634405525 3644 5280373 A possible chelator. SGTC_3205 9113483 49.47 µM -0.708159011073895 0.231404715816903 no 2583 0.23942325853905 3709 17018033 SGTC_1396 3511-0007 98.6 µM -0.708786154143976 0.231226874870192 no 2584 0.239228595617564 3649 X1396 SGTC_2772 vinpocetine 57.06 µM -0.708869436053543 0.231203264091885 no 2585 0.239202751722674 3702 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1704 st028805 70.8 µM -0.710270860380558 0.230806156111945 no 2586 0.238768093119176 3708 2876101 SGTC_2890 9046729 58.44 µM -0.711974792627451 0.230323842966792 no 2587 0.238240192779543 3639 903329 SGTC_338 4055-0136 114 µM -0.712815134514049 0.230086184409854 no 2588 0.237980079564911 3657 2900563 SGTC_3050 9093513 49.47 µM -0.714740520829835 0.229542180217417 no 2589 0.23738469715341 3705 25236664 SGTC_1214 0358-0031 63.7 µM -0.715052407374501 0.229454126768651 no 2590 0.237288330283405 3759 4301366 SGTC_2277 7947813 106.88 µM -0.716322548787985 0.229095729354606 no 2591 0.236896103314979 3752 1246798 SGTC_1257 0669-0121 16 µM -0.717369498000863 0.228800546608608 no 2592 0.23657306755265 3741 4307855 SGTC_1738 st035555 74 µM -0.72035582053174 0.227959740170865 no 2593 0.23565297201271 3715 5331140 SGTC_847 0342-0274 5.54 µM -0.720360808176856 0.227958337342611 no 2594 0.235651436956048 3719 18097 SGTC_118 0083-0097 135.343 µM -0.721403496907402 0.227665176691463 no 2595 0.235330647861811 3765 5207356 SGTC_1693 xanthone 101.9 µM -0.721620298274987 0.227604247839183 no 2596 0.235263977977974 3770 7020 An insecticide. SGTC_517 1365-0151 113 µM -0.726029195467861 0.226367185354477 no 2597 0.233910436414622 3763 768657 SGTC_827 3253-0474 693 µM -0.727712270188866 0.225895946281109 no 2598 0.233394868793465 3716 5402065 SGTC_221 trifluoperazine 10.304 µM -0.728217237457806 0.22575467025803 no 2599 0.233240307809977 3722 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_105 0111-0055 734.78 µM -0.728524930885517 0.225668610568076 no 2600 0.233146156499927 3730 5179370 SGTC_1256 0570-0116 285 µM -0.732209307409731 0.224639559255014 no 2601 0.232020412154805 3739 410638 SGTC_637 1181-0519 7.26 µM -0.732426898857383 0.224578869025553 no 2602 0.231954022863037 3740 6252091 YGR060W ERG25 SGTC_2765 myclobutanil 7.74 µM -0.732622968781675 0.224524189510485 no 2603 0.23189420906152 3742 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_161 4065-0411 162.148 µM -0.733116241098562 0.224386660309893 no 2604 0.23174376761909 3763 1906281 YLR208W SEC13 SGTC_594 1487-1584 10.8 µM -0.733425463145419 0.224300470532687 no 2605 0.231649486776914 3710 5013332 SGTC_3179 9107801 49.47 µM -0.7334945602174 0.224281213604655 no 2606 0.23162842221647 3733 4818259 SGTC_507 nimesulide 162 µM -0.734579814232163 0.223978883170745 no 2607 0.231297717625785 3761 4495 A COX2 inhibitor. SGTC_2220 6782180 200 µM -0.735202243369989 0.223805591185535 no 2608 0.231108166489933 3652 833803 SGTC_2030 5175110 200 µM -0.735489705925671 0.22372558378084 no 2609 0.231020653501231 3760 2831986 SGTC_732 3970-1727 52.7 µM -0.735918405408966 0.223606297120953 no 2610 0.230890177749 3738 1275699 SGTC_2084 5306078 60.6385 µM -0.737480377757725 0.223171980668108 no 2611 0.230415135829693 3673 679340 SGTC_2895 9054447 58.44 µM -0.737913452584868 0.223051646520388 no 2612 0.230283521800511 3763 2697450 SGTC_2401 5128683 200 µM -0.738702514355903 0.222832492878959 no 2613 0.230043829331193 3709 708373 SGTC_2576 guaiol 23.12 µM -0.739157651953063 0.222706138992103 no 2614 0.229905636171617 3743 227829 SGTC_863 0466-0191 129 µM -0.740358111512509 0.222373067104383 no 2615 0.229541364366446 3744 765160 YPR165W RHO1 SGTC_1838 st055369 84.5 µM -0.741218851376422 0.222134426695897 no 2616 0.229280377524509 3725 676036 SGTC_329 k048-0121 21.3 µM -0.741657280801219 0.222012928205199 no 2617 0.229147504348128 3731 6832902 SGTC_2786 7743617 45.45 µM -0.742303370188814 0.221833951716863 no 2618 0.228951775177267 3702 583674 SGTC_2356 9061756 188.97 µM -0.742944627687157 0.221656395251608 no 2619 0.2287576025981 3741 20104043 SGTC_2866 9034245 58.44 µM -0.744544354352293 0.221213804408792 no 2620 0.228273609065355 3745 6462273 SGTC_2253 7938677 135.83 µM -0.745311838269507 0.221001646866133 no 2621 0.228041613084873 3779 2301972 SGTC_2918 7977171 22.06 µM -0.746428085653559 0.220693287704485 no 2622 0.227704429267985 3691 2236483 SGTC_1063 disulfiram 1.84 µM -0.748684160745201 0.220070808370641 no 2623 0.227023796305818 3755 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3262 9137218 49.47 µM -0.750792030784243 0.219490131843592 no 2624 0.226388913111473 3601 17650664 SGTC_2699 st077704 54.6 µM -0.752561736584172 0.219003293292897 no 2625 0.225856659047968 3788 645852 SGTC_1456 k015-0012 13 µM -0.753106369909107 0.218853592047243 no 2626 0.225692998463631 3806 2989616 SGTC_781 4335-2806 94.4 µM -0.753613110852168 0.218714359021485 no 2627 0.225540784691936 3889 845254 SGTC_223 busulfan 5 mM -0.754562211413628 0.218453719702991 no 2628 0.225255852249246 3758 2478 A DNA alkylator. SGTC_3213 9129884 49.47 µM -0.755615478602988 0.218164683950395 no 2629 0.224939886415708 3752 17190742 SGTC_934 2950-0684 338 µM -0.758726824355779 0.217312162093959 no 2630 0.224007993558603 3815 1121253 SGTC_1516 st013856 110 µM -0.759688748779925 0.217048980602496 no 2631 0.223720327840413 3798 5281404 A mutagen and neurotoxin. SGTC_832 4083-0019 164 µM -0.761426984988939 0.216573868461503 no 2632 0.223201037326095 3847 1990758 SGTC_2988 9073640 71.4286 µM -0.762300615476391 0.216335306388709 no 2633 0.222940303325865 3788 9102229 SGTC_667 1498-1044 59 µM -0.762329666603517 0.216327376018322 no 2634 0.222931636032469 3785 6739982 SGTC_740 k014-0057 261 µM -0.762473682453518 0.216288065087752 no 2635 0.222888672285225 3785 4012779 SGTC_1853 st056710 91.2 µM -0.763582909824847 0.215985426202346 no 2636 0.222557918467652 3871 269167 SGTC_3232 9132874 49.47 µM -0.763623357228198 0.215974395269637 no 2637 0.222545862991111 3766 3784940 SGTC_2844 9010103 25.97 µM -0.764186602585415 0.215820819291009 no 2638 0.222378024628565 3805 2480525 SGTC_1907 st060210 83.7 µM -0.765450829248744 0.215476342437702 no 2639 0.222001567758427 3782 688793 SGTC_3166 9102297 49.47 µM -0.765833442382703 0.215372150798721 no 2640 0.221887706359618 3760 25237072 SGTC_2514 salinomycin 42.74 µM -0.765987967539818 0.215330079429767 no 2641 0.221841730853697 3871 23682228 A polyether potassium ionophore. SGTC_2820 7989630 71.43 µM -0.766300880839527 0.215244899553747 no 2642 0.221748647163769 3664 2984098 SGTC_1131 3454-3128 32.3 µM -0.766660187825366 0.21514711471721 no 2643 0.221641790067101 3861 710982 SGTC_562 3772-2733 112 µM -0.768915405119943 0.214533950009077 no 2644 0.220971765795417 3810 2876874 YIL048W NEO1 SGTC_3071 9117417 49.47 µM -0.770604088446845 0.214075484529455 no 2645 0.220470818552365 3724 45595590 YGL055W OLE1 SGTC_994 3910-0338 138 µM -0.771707887633916 0.213776119336544 no 2646 0.220143729003941 3877 3479481 SGTC_1903 st060211 78.3 µM -0.775111828169447 0.212854461542639 no 2647 0.219136791439561 3838 688960 SGTC_1736 st036774 51 µM -0.776558066552561 0.212463578218986 no 2648 0.21870977490061 3890 1272247 SGTC_1562 morin hydrate 59.1 µM -0.776565138616 0.212461667841863 no 2649 0.218707687979553 3845 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2311 7694451 200 µM -0.777509148991459 0.212206752321643 no 2650 0.218429219395832 3762 2163142 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.77935469810823 0.211708906861784 no 2651 0.217885400968675 3825 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2543 pimpinellin 60.67 µM -0.781888492243774 0.211026518752279 no 2652 0.217140054296781 3700 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_56 0957-0365 83.25 µM -0.782025112805813 0.210989761492139 no 2653 0.217099907578156 3778 6752360 SGTC_1703 st026983 48.3 µM -0.78415343805507 0.210417628258942 no 2654 0.216475041302042 3794 1104023 SGTC_1105 epirubicin 18.1 µM -0.787148655805623 0.20961400289979 no 2655 0.215597424764754 3810 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2456 5770359 74.46 µM -0.788054939314989 0.20937120066538 no 2656 0.215332285467107 3797 3118787 SGTC_1635 st007035 42.4 µM -0.78812879401723 0.209351421562649 no 2657 0.215310687120811 3802 3716403 SGTC_876 0720-0963 56.8 µM -0.788427760585122 0.209271366258672 no 2658 0.215223269060746 3812 765861 SGTC_1238 0333-0287 48.8 µM -0.789782514542025 0.208908825036105 no 2659 0.214827396194814 3810 7226 SGTC_2718 lomofungin 53.02 µM -0.790015964547209 0.20884638964592 no 2660 0.21475922248491 3785 5351222 A RNA synthesis inhibitor. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.790117654973947 0.208819196333644 no 2661 0.214729530063231 3849 688798 SGTC_128 0906-2981 13.371 µM -0.790287412521931 0.208773805656932 no 2662 0.214679968149278 3743 6740226 SGTC_1118 chelidonine 707.474 nM -0.790749319030758 0.208650328073429 no 2663 0.214545144944099 3795 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2022 5136654 200 µM -0.791189807442894 0.208532616119406 no 2664 0.214416619206401 3858 1713771 SGTC_2252 omeprazole 400 µM -0.792422037262614 0.208203534729169 no 2665 0.21405731701164 3764 4594 A proton pump inhibitor. SGTC_2453 5731132 22.18 µM -0.793304738636528 0.207967987492449 no 2666 0.213800148327714 3851 1362040 SGTC_745 0469-0705 296 µM -0.79481611575672 0.207565044800067 no 2667 0.213360237533943 3891 3486736 SGTC_1169 aniline yellow 25.8 µM -0.796514118746257 0.207112897248202 no 2668 0.2128666362564 3772 6051 A DNA damaging agent. SGTC_2533 agelasine 13.65 µM -0.797768870212479 0.206779154246718 no 2669 0.212502314669227 3861 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_45 0kpi-0036 14.9 µM -0.79982483778744 0.206232989871392 no 2670 0.211906145151948 3830 2795021 SGTC_1357 1503-1303 39.5 µM -0.803198285716528 0.205338693951012 no 2671 0.210930068099869 3813 292895 SGTC_2608 thymoquinone 42.66 µM -0.803421534215958 0.205279592488699 no 2672 0.210865566272249 3804 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_904 1141-0088 396 µM -0.803457278657746 0.205270130659222 no 2673 0.210855239922987 3852 1378119 SGTC_1996 st072960 66.8 µM -0.804527006021904 0.204987085492478 no 2674 0.210546339532946 3796 1719405 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.804806589226061 0.204913147264886 no 2675 0.210465649337371 3838 5357218 A potent inhibitor of glutathione S-transferases. SGTC_306 1672-3436 11.6 µM -0.805123758061894 0.204829288388142 no 2676 0.210374133573776 3842 6797378 SGTC_2831 7999036 19.48 µM -0.805452585193641 0.204742368629895 no 2677 0.210279278601001 3907 2988270 SGTC_2302 7771753 200 µM -0.80680822721495 0.204384259868698 no 2678 0.209888489214409 3856 2203047 SGTC_291 SEC14.278 35.5 µM -0.807445372595481 0.204216079317589 no 2679 0.209704967594218 3833 1068044 SGTC_3 0833-0587 95.581 µM -0.808729089238655 0.20387748056476 no 2680 0.209335496047133 3778 5382644 SGTC_2055 5235184 200 µM -0.811086354236047 0.203256589970329 no 2681 0.20865804082699 3888 2836034 SGTC_1739 st037196 92.5 µM -0.811251982748245 0.203213006807408 no 2682 0.20861048943044 3886 612214 SGTC_1805 st050013 60.3 µM -0.811410233590448 0.203171370201467 no 2683 0.20856506210682 3804 4037144 SGTC_1626 st003712 1.76 µM -0.812386877788743 0.202914522831444 no 2684 0.208284836720978 3819 24207035 SGTC_873 0591-4978 488 µM -0.813096130215979 0.202728118365429 no 2685 0.208081472496737 3895 3305145 SGTC_3117 9124945 49.47 µM -0.813623249252467 0.202589648179177 no 2686 0.207930407396824 3760 17592065 SGTC_1899 st063254 59.6 µM -0.813672215024017 0.202576788111456 no 2687 0.207916377764814 3781 3093813 SGTC_1385 3091-4834 14.1 µM -0.81371189601052 0.20256636690027 no 2688 0.207905008811693 3846 4072814 SGTC_2856 9022925 19.48 µM -0.818210910659572 0.201386893084122 no 2689 0.206618383073012 3896 4944862 SGTC_2309 7664088 163.95 µM -0.820325325956275 0.200833997054782 no 2690 0.206015336229078 3855 704922 SGTC_3194 9111903 49.47 µM -0.820414254373398 0.200810763244334 no 2691 0.205989996083637 3855 17087251 SGTC_1979 st071809 45.3 µM -0.820838044476184 0.200700064230584 no 2692 0.20586926252561 3970 4976333 SGTC_2198 6589944 200 µM -0.822587352769663 0.200243511929908 no 2693 0.205371346582543 3861 5290268 SGTC_2640 pentamidine 10.38 µM -0.822756990481985 0.200199271370405 no 2694 0.205323099673017 3874 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2823 7987624 58.44 µM -0.825946821374379 0.199368475601598 no 2695 0.204417129411908 3859 2239440 SGTC_2045 5106652 78.05 µM -0.826583099024333 0.199203004900935 no 2696 0.204236700006802 3850 673349 SGTC_1358 1509-0022 2.48 µM -0.828455942580185 0.198716432517726 no 2697 0.203706167986446 3906 3258434 SGTC_3124 9127567 49.47 µM -0.828539679482417 0.19869469407971 no 2698 0.203682466519979 3829 17592030 SGTC_3328 9140624 29.0385 µM -0.829597561453419 0.198420187157009 no 2699 0.203383177984077 3909 4904392 SGTC_2915 7971052 15.16 µM -0.830866159529283 0.198091303991401 no 2700 0.203024621333987 3725 5741558 SGTC_1678 st019265 80.2 µM -0.831266097826365 0.197987688548262 no 2701 0.20291166105003 3848 5367020 SGTC_2225 6654152 15.4 µM -0.831749950204021 0.197862376530267 no 2702 0.202775049906431 3772 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_324 1315-0088 19.6 µM -0.833265963428145 0.197470057483216 no 2703 0.202347373873087 3853 6787421 SGTC_205 1486-1330 71.903 µM -0.833503450683223 0.197408642365562 no 2704 0.202280426261944 3868 4118834 SGTC_576 1073-0113 22.7 µM -0.834518782390135 0.197146203964461 no 2705 0.201994353890621 4034 5439563 SGTC_534 k292-0788 63.4 µM -0.834874977133792 0.197054186383733 no 2706 0.201894052492057 3875 4146317 SGTC_211 3455-0679 143.504 µM -0.835543181757741 0.196881635854837 no 2707 0.201705972228058 3922 748649 SGTC_479 n-linoleoylglycine 10 µM -0.835827257514834 0.196808306672263 no 2708 0.20162604492374 3908 6433346 An anti-infammatory. SGTC_2279 7948423 32.93 µM -0.837691380076568 0.196327526541058 no 2709 0.20110202794306 3816 1247112 SGTC_1836 st055642 81 µM -0.838621814435368 0.196087822678693 no 2710 0.200840782660772 3894 8571 SGTC_3209 9113616 49.47 µM -0.841072467720596 0.195457321259345 no 2711 0.200153669017674 3864 16649353 SGTC_1939 st074455 53.6 µM -0.841102225701163 0.195449672732867 no 2712 0.200145334173215 3865 1644229 SGTC_39 0986-0283 58.349 µM -0.841913067599855 0.195241336563516 no 2713 0.199918307619332 3980 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2335 9018011 154.17 µM -0.845311125064647 0.194369714877004 no 2714 0.198968575602754 3929 6458208 SGTC_2642 cholecalciferol 100 µM -0.84590999553151 0.194216347005796 no 2715 0.198801477985108 3868 9821465 A vitamin D precursor, similar to steriods. SGTC_474 dl-dihydrosphingosine 5 µM -0.849036063009597 0.193416973144903 no 2716 0.197930612801673 3888 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2412 st077135 33.4 µM -0.850068223522362 0.193153478451126 no 2717 0.197643578564494 4005 13258915 SGTC_2913 7966556 36.57 µM -0.850471380567916 0.193050618201882 no 2718 0.197531532702001 3772 2976516 SGTC_3334 9142812 21.919 µM -0.851744866548776 0.192725924651626 no 2719 0.197177856357031 3947 45283678 SGTC_1185 1319-0113 81.3 µM -0.852959852093975 0.192416457875072 no 2720 0.196840784330363 3970 4672763 SGTC_3039 9090270 49.47 µM -0.853300123333342 0.192329842494004 no 2721 0.196746445852803 3875 17173750 SGTC_3200 9114385 49.47 µM -0.853758246081344 0.192213265910092 no 2722 0.196619476900465 3959 17018030 YLR208W SEC13 SGTC_3118 9124250 49.47 µM -0.854787720893809 0.191951457495795 no 2723 0.196334338593521 3858 1504786 SGTC_1568 digitonin 820 nM -0.856354232539826 0.191553492840808 no 2724 0.195900935972754 3887 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1430 4049-0248 69.1 µM -0.857934618769568 0.191152516005849 no 2725 0.1954642834653 3924 22774488 SGTC_1347 1493-0251 600 nM -0.858464134508729 0.191018282043173 no 2726 0.195318113327907 3964 3986378 SGTC_215 1287-0124 461.5 µM -0.859856761538733 0.190665522623057 no 2727 0.194934002817013 3926 5560863 SGTC_2425 5628681 7.85 µM -0.861583820543369 0.190228605728432 no 2728 0.194458288752744 3988 5714958 SGTC_715 0868-0130 184 µM -0.862220852390917 0.190067602790133 no 2729 0.19428299848124 3943 2876258 SGTC_1761 st044296 37 µM -0.862987152469217 0.189874039699024 no 2730 0.194072265367686 3917 1826700 SGTC_2182 6325192 200 µM -0.864474213730919 0.189498762345502 no 2731 0.193663719888309 3839 736248 SGTC_522 1273-0010 11.6 µM -0.866225199649714 0.189057466068386 no 2732 0.193183338346117 4052 5705015 SGTC_2396 5342950 42.78 µM -0.8667412458637 0.188927529186949 no 2733 0.193041900382705 3930 1886677 SGTC_2549 cedrol 20.94 µM -0.867446244194134 0.188750104416335 no 2734 0.192848776644328 3842 6708665 A sedative which affects the nervous system. SGTC_2626 ethyl orsellinate 100 µM -0.867534676253573 0.188727856241796 no 2735 0.192824560338891 3943 75653 A natural product. SGTC_286 k060-0067 22.9 µM -0.869419431339689 0.188254064652137 no 2736 0.192308879318092 3926 5985051 SGTC_46 0329-0187a 2.197 µM -0.869590745229736 0.188211036012104 no 2737 0.19226204859774 3999 46494817 SGTC_3237 9133362 49.47 µM -0.869656093139691 0.18819462427954 no 2738 0.192244186795522 3862 43845137 SGTC_2015 5119600 184 µM -0.869987106766759 0.188111505774589 no 2739 0.192153725127634 3970 2828786 SGTC_1321 1326-2144 215 µM -0.870959529922242 0.187867458507656 no 2740 0.191888125341297 3940 3513030 SGTC_1722 st034304 3.6505 µM -0.871023851552433 0.187851322722218 no 2741 0.191870564979813 3930 4036148 YLR033W RSC58 SGTC_1087 pterostilbene 9.05 µM -0.872911496265899 0.187378167533405 no 2742 0.19135565980012 3994 5281727 Similar to reservatol, lowers cholesterol. SGTC_1659 st012954 42.1 µM -0.87312586160393 0.187324481546725 no 2743 0.191297239560073 3922 24207262 SGTC_229 benomyl 22.8748 µM -0.87338097041227 0.187260604096058 no 2744 0.191227729891755 3945 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_988 1497-1057 103 µM -0.873858495473071 0.187141071386461 no 2745 0.19109765994112 3856 3533044 SGTC_2879 9041815 71.43 µM -0.874056464827685 0.187091530103194 no 2746 0.191043752265538 3944 4942971 SGTC_2714 st079313 56.9 µM -0.874872161176491 0.186887489933227 no 2747 0.190821733988593 3910 2939799 SGTC_2266 7929956 200 µM -0.877948281432052 0.186119261632011 no 2748 0.189985893023367 3896 2967153 SGTC_2200 6600604 21.907 µM -0.878719672014383 0.185926922440221 no 2749 0.189776644843502 3912 2904777 SGTC_1058 3448-5425 97.3 µM -0.87911108200325 0.185829375090259 no 2750 0.189670524801945 3810 7279705 SGTC_1457 k015-0032 57.3 µM -0.879132695089097 0.185823989593503 no 2751 0.189664666072412 3938 4302660 SGTC_2398 5228213 48.84 µM -0.881076000472238 0.185340157135702 no 2752 0.189138343011838 3944 80771 YMR134W ERG29 SGTC_355 1311-2252 105 µM -0.882633830952262 0.184952863248943 no 2753 0.188717071809443 3951 5338538 SGTC_108 0509-0257 621.132 µM -0.884554309440957 0.184476103731595 no 2754 0.188198529388278 3914 536624 SGTC_2720 fluspirilene 36.88 µM -0.88533469320388 0.184282591783457 no 2755 0.187988071857547 3948 3396 An atypical antipsychotic. SGTC_1856 st057054 55.7 µM -0.88996798706724 0.183136275764713 no 2756 0.186741537908622 3972 1266018 SGTC_871 0574-0004 149 µM -0.890253668937338 0.183065741540913 no 2757 0.186664846347916 3931 9551173 SGTC_1451 4152-0210 104 µM -0.892247159409311 0.182574025015517 no 2758 0.186130234925575 3938 659563 SGTC_518 1021-0119 62.6 µM -0.894185989712668 0.182096583052548 no 2759 0.185611193527844 3943 1097762 SGTC_2004 4023728 41.89 µM -0.895224867277415 0.181841078234315 no 2760 0.185333447063007 3969 360084 YDR527W RBA50 SGTC_799 1310-0557 151 µM -0.89640024510965 0.181552272628827 no 2761 0.185019518227488 4040 5354492 SGTC_2436 5633522 8.09 µM -0.897192896585952 0.181357670036424 no 2762 0.184807997490331 3942 5724242 SGTC_213 1246-0773 967 nM -0.898025823545891 0.181153320259247 no 2763 0.184585891181754 3948 6251622 SGTC_2495 cafestol 54.53 µM -0.898420027373912 0.181056656843757 no 2764 0.184480831628926 3993 16667697 An anti-infammatory. SGTC_1866 st057638 64 µM -0.901043063870448 0.180414280634506 no 2765 0.183782711718879 3941 688802 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.904184331707186 0.179646874683989 no 2766 0.18294883346431 4007 5024745 SGTC_196 k015-0023 18.111 µM -0.906700022438207 0.179033777484053 no 2767 0.18228272578332 3916 5211998 SGTC_815 1582-0027 36.9 µM -0.907111961514401 0.178933509686522 no 2768 0.182173796631075 4047 3128206 SGTC_1380 2291-0730 164 µM -0.907275854563069 0.17889362722074 no 2769 0.182130469667956 4019 2999191 SGTC_1158 4092-0494 91.8 µM -0.911790127980694 0.17779730380113 no 2770 0.180939604069222 4076 1148199 SGTC_1716 st033144 30.6155 µM -0.913235878211996 0.177447090991393 no 2771 0.180559249034345 3985 674617 SGTC_3261 9137475 49.47 µM -0.913299620593448 0.177431660319023 no 2772 0.180542490927264 3892 17027690 SGTC_1210 3013-0140 750 nM -0.916012475993709 0.176775721163792 no 2773 0.179830175673363 4026 905973 SGTC_1685 st024049 53.0905 µM -0.91755905213062 0.176402462698008 no 2774 0.179424881886021 4017 1941139 SGTC_1201 1889-3372 45.9 µM -0.917972576493642 0.17630274519063 no 2775 0.179316611588802 3868 5392199 SGTC_639 0833-0042 114 µM -0.918894191129864 0.176080634857044 no 2776 0.179075459286864 3991 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_333 3486-0131 40.1 µM -0.918926863331621 0.176072764066318 no 2777 0.179066913932334 4047 6744690 SGTC_2076 5212012 200 µM -0.920825669965472 0.175615720871781 no 2778 0.17857072530519 3923 604802 SGTC_2524 avocatin b 10.57 µM -0.921816082388012 0.175377626972875 no 2779 0.178312258615154 3947 6710748 SGTC_59 0330-0160 1.33 µM -0.924535200979759 0.174725007085885 no 2780 0.177603866448389 3954 4293482 SGTC_1876 myriocin 605 nM -0.927706834586667 0.173965729002469 no 2781 0.176779831118636 3998 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_270 tamoxifen 5.46 µM -0.929695534836755 0.173490712847464 no 2782 0.176264373512074 4021 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2491 paeonol 100 µM -0.930215735961678 0.173366595195483 no 2783 0.176129698004309 3866 11092 Increases levels of cortical cytochrome oxidase. SGTC_872 0588-0139 234 µM -0.932493294972438 0.172823845603162 no 2784 0.175540825110416 3974 2047100 SGTC_1140 3229-1848 2.98 µM -0.933133968858603 0.17267136633413 no 2785 0.175375401189272 4039 2849525 SGTC_2208 7283366 200 µM -0.933814573882122 0.172509477504604 no 2786 0.175199775230422 3965 898663 SGTC_2160 5660466 132.927 µM -0.934336468213222 0.172385405219136 no 2787 0.175065179181524 3902 2859134 SGTC_1011 4112-3381 17.4 µM -0.934388564308264 0.172373023305674 no 2788 0.175051747250217 4082 2877139 SGTC_2935 9038016 29.96 µM -0.936326011553654 0.171912944415419 no 2789 0.174552679752856 4025 6463195 SGTC_3257 9139206 32.98 µM -0.936348875610082 0.171907519652458 no 2790 0.174546795594874 4014 4910041 SGTC_631 k072-0230 41.5 µM -0.936539676757468 0.171862254126008 no 2791 0.174497697054931 4028 5773147 SGTC_610 4215-0184 155 µM -0.938254420392265 0.171455791204646 no 2792 0.174056838669264 4036 5605015 SGTC_3133 9127736 49.47 µM -0.938379122474683 0.171426255800148 no 2793 0.174024805566262 3969 27243420 SGTC_842 0271-0008 11.1 µM -0.940576537682839 0.17090633659903 no 2794 0.173460955041252 4074 1221709 SGTC_3342 9147791 14.508 µM -0.946389770180439 0.169535768206892 no 2795 0.171974910580913 3925 1838168 SGTC_958 1222-0007 33 µM -0.949467380698921 0.168813032208592 no 2796 0.171191477299296 4114 7312461 SGTC_1154 4088-0362 150 µM -0.949904485388949 0.168710544759394 no 2797 0.171080393761392 4019 6618304 SGTC_2752 diclazuril 33.15 µM -0.952402092724835 0.168125700800558 no 2798 0.170446549272106 4008 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2819 7996655 46.38 µM -0.953243417928387 0.167928988742966 no 2799 0.170233376252516 3996 6456960 SGTC_3105 9121040 49.47 µM -0.953853346305116 0.167786472748254 no 2800 0.170078940874751 3863 41448907 SGTC_222 nsc-310342 10.666 µM -0.954526431419451 0.167629289954097 no 2801 0.169908618308997 3999 432556 SGTC_48 0382-0018 55 µM -0.954609476696489 0.167609903307334 no 2802 0.16988761148278 4059 762596 SGTC_214 4373-3496 70 µM -0.955298734528066 0.167449054071343 no 2803 0.169713323639273 4103 3779166 SGTC_2290 7904846 200 µM -0.95545501331352 0.167412597776903 no 2804 0.169673822461849 4088 2962154 SGTC_2744 captopril 92.04 µM -0.961056398127523 0.166109299267637 no 2805 0.168261905658013 4070 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1322 1348-1070 12 µM -0.961363191928179 0.166038106069931 no 2806 0.168184792402326 4032 6758089 SGTC_2393 9031399 185.94 µM -0.961654929485289 0.165970425047741 no 2807 0.168111484658371 4105 1526623 YDL150W RPC53 SGTC_3137 9097352 49.47 µM -0.962608168281238 0.165749404797103 no 2808 0.167872098409753 4062 44120435 SGTC_1531 st059297 52.4 µM -0.96579019750074 0.165012990330762 no 2809 0.167074587275038 4055 7566702 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.966306332282107 0.1648937416539 no 2810 0.166945459195481 4055 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_908 3448-7491 47.7 µM -0.967304831876917 0.164663205035588 no 2811 0.166695834469411 4053 1203031 SGTC_2437 5741531 144.16 µM -0.968814955710108 0.164314940014879 no 2812 0.166318761614824 4083 2262990 SGTC_2415 st077333 57.7 µM -0.970617677371527 0.163899821854729 no 2813 0.165869349899839 4102 2766255 SGTC_941 3237-0776 460 µM -0.973598785840197 0.163214847563485 no 2814 0.165127894716555 4118 760008 SGTC_2371 9071574 200 µM -0.975699509811643 0.162733279580127 no 2815 0.164606697612194 4080 45596039 SGTC_33 0986-0033 35.816 µM -0.975863071486848 0.162695823674053 no 2816 0.164566162156485 3992 2848082 SGTC_1344 1488-0097 29.1 µM -0.975942961022989 0.162677530870933 no 2817 0.16454636550116 4085 747966 SGTC_2202 7226349 200 µM -0.980776460575861 0.161573263884372 no 2818 0.163351494400895 4016 844334 SGTC_945 3381-0768 11.3 µM -0.980980233019298 0.161526817393316 no 2819 0.163301244719877 4114 1126236 YIL048W NEO1 SGTC_1565 sinapyl alcohol 95.1 µM -0.981030898434387 0.161515270418025 no 2820 0.163288752337653 4110 5280507 A phenol propionate derived from cinnamic acid. SGTC_84 0443-0269 128.823 µM -0.9819911756052 0.161296518819331 no 2821 0.163052097790728 3952 6150058 SGTC_80 0159-0065 512.242 µM -0.984074203489673 0.160822668649219 no 2822 0.162539514788117 3941 1548079 SGTC_2247 cerulenin 830 nM -0.988262672191123 0.159872623693101 no 2823 0.161512010793686 4127 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_445 e6 berbamine 66 µM -0.989442392099612 0.1596056989441 no 2824 0.161223371114922 4105 6610268 A calcium/calmodulin antagonist. SGTC_3064 1327-0027 10 µM -0.989774454990217 0.159530618654934 no 2825 0.161142186688882 3978 16000455 YPR107C YTH1 SGTC_2805 7950783 58.44 µM -0.990505060892192 0.159365508148152 no 2826 0.160963658360899 4093 1178958 YDL195W SEC31 SGTC_1507 4075-3230 155 µM -0.990598730947824 0.159344347634696 no 2827 0.160940778810894 3949 659771 SGTC_2243 6634756 200 µM -0.991044808595773 0.159243601804704 no 2828 0.160831850429775 4157 885676 SGTC_1972 st070201 17.4 µM -0.993177037022768 0.158762618265898 no 2829 0.160311843392917 4082 2829099 SGTC_2616 abietic acid 100 µM -0.993381967130556 0.158716440786035 no 2830 0.160261923061373 4113 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1808 st050063 61.5 µM -0.994157111692773 0.15854185492479 no 2831 0.160073192185786 4058 4011993 SGTC_3302 9125395 16.351 µM -0.994620561688309 0.158437532236143 no 2832 0.159960421617889 4030 17599668 SGTC_743 1275-0778 158 µM -0.99472084245176 0.158414964942917 no 2833 0.159936027294665 4074 2849257 YMR203W TOM40 SGTC_3174 9107204 49.47 µM -0.995381298381145 0.158266387892902 no 2834 0.159775425408028 4126 3938802 SGTC_164 4100-3994 89.624 µM -0.998294510654167 0.157612119294704 no 2835 0.159068284333344 4015 4615967 SGTC_2466 5983409 37.09 µM -0.999129688334362 0.157424877758287 no 2836 0.15886593551518 4106 2879657 SGTC_526 4469-0568 170 µM -1.00221261086551 0.156734972506809 no 2837 0.158120459178374 4025 2901964 SGTC_2 0422-0095 29 µM -1.00315672062263 0.156524095516481 no 2838 0.157892625558526 3985 6790840 SGTC_1814 st052110 31.539 µM -1.00610219375236 0.155867393739366 no 2839 0.157183206764055 4046 674163 SGTC_1701 st028638 40.4 µM -1.0082605703477 0.155387332259776 no 2840 0.15666469332663 4104 3490878 SGTC_895 0964-0006 13.7 µM -1.00847732123072 0.155339176961624 no 2841 0.15661268487738 4065 6738897 SGTC_816 0325-0417 81.3 µM -1.00953823148851 0.155103617821086 no 2842 0.156358287970313 4114 68101 SGTC_1646 st011709 75.6 µM -1.01003910754475 0.154992487838187 no 2843 0.156238276950997 4030 5757843 SGTC_1271 0832-2808 169 µM -1.01077160429712 0.154830062588783 no 2844 0.156062878388753 4135 3663794 SGTC_2840 9008771 71.43 µM -1.01086491079311 0.154809380702264 no 2845 0.156040545187381 4042 2992978 SGTC_1424 4048-1941 275 µM -1.01268866606469 0.154405502009969 no 2846 0.155604446604363 4172 X1424 SGTC_2024 5144227 134 µM -1.01346055294606 0.154234774238203 no 2847 0.155420114435102 4159 3475211 SGTC_2568 diosmetin 100 µM -1.01417355856599 0.154077180930873 no 2848 0.155249971605473 4159 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_365 0121-0052 13.6 µM -1.01418661025922 0.154074297150876 no 2849 0.155246858257331 4144 3101739 SGTC_2027 5150920 200 µM -1.01469782640187 0.153961371706011 no 2850 0.155124945285996 4042 786715 SGTC_1482 3346-2049 8.48 µM -1.01688410312732 0.153479050670151 no 2851 0.15460428328451 4104 3826804 SGTC_753 1322-0200 289 µM -1.02202595020981 0.152348641056852 no 2852 0.153384309215194 4190 5403907 SGTC_2420 aureobasidin a 50 nM -1.02403596188969 0.151908256175846 no 2853 0.152909144687554 4243 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2878 9043973 25.97 µM -1.02768947180939 0.151109955597136 no 2854 0.152047960895285 4169 6465167 SGTC_2394 5221648 200 µM -1.03230802772236 0.15010479177658 no 2855 0.150963920798549 4181 788586 SGTC_3037 9091026 49.47 µM -1.0323137486495 0.150103549467599 no 2856 0.150962581214088 4059 25236398 YIL048W NEO1 SGTC_2129 girgensonine 121.053 µM -1.03337297486862 0.149873654821856 no 2857 0.150714694286878 4145 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1776 st049249 45.9 µM -1.03742126189225 0.148997178691044 no 2858 0.149769786792534 4148 1822314 SGTC_2010 4012422 159 µM -1.03902506982581 0.148650894481585 no 2859 0.149396538506959 4096 952393 SGTC_1520 flindersine 88 µM -1.04060785924762 0.14830967634385 no 2860 0.149028791080427 4225 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_717 1532-0246 73.2 µM -1.04210727438053 0.147986915693383 no 2861 0.148680973174711 4124 9561992 SGTC_3253 9135987 49.47 µM -1.04245309944059 0.147912540960676 no 2862 0.148600829535597 4147 4182430 SGTC_2545 solidagenone 89.61 µM -1.0445194673533 0.14746865986335 no 2863 0.148122558599259 3963 6708572 An anti ulcer agent SGTC_1181 1222-0449 220 µM -1.04548169708231 0.147262266030248 no 2864 0.147900197732599 4211 658318 SGTC_979 1426-2828 121 µM -1.04720478863749 0.146893154858008 no 2865 0.147502568593417 4243 747872 SGTC_427 1354-0053 47.3 µM -1.0477875377639 0.14676846209894 no 2866 0.147368252740043 4215 6813657 SGTC_3017 9080681 49.47 µM -1.0507812826062 0.146129000325399 no 2867 0.146679527124357 4154 16451914 SGTC_943 3253-1379 105 µM -1.05284848959658 0.145688540272923 no 2868 0.146205218648217 4173 668464 SGTC_967 1306-0166 352 µM -1.05295068414534 0.145666788844442 no 2869 0.146181797461353 4153 4437607 SGTC_234 nsc-17383 10.7 µM -1.05888607263172 0.144407226208097 no 2870 0.144825833913015 4174 408974 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.05917372772224 0.144346369295222 no 2871 0.144760333826561 3990 88881 An O-methylated flavonoid and antioxidant. SGTC_963 1269-2853 151 µM -1.06265346429173 0.143611558265109 no 2872 0.143969565868162 4147 3668223 SGTC_651 3253-0966 34.4 µM -1.06563884278769 0.142983155622642 no 2873 0.143293466665334 4177 781462 SGTC_2594 a-mangostin 100 µM -1.06851277861884 0.142379968735132 no 2874 0.142644634641176 4203 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1540 guanosine 70.6 µM -1.06861869947731 0.142357770811971 no 2875 0.142620759512055 4034 6802 Guanosine is a purine nucleoside SGTC_809 3998-0021 90 µM -1.06888612846204 0.142301735913854 no 2876 0.142560491609899 4120 715485 SGTC_2523 spermine 47.74 µM -1.06970373895345 0.142130513016178 no 2877 0.142376341416245 4188 1103 A DNA binding polyamine. SGTC_2354 9060492 162 µM -1.07147785085325 0.141759460578932 no 2878 0.14197731229514 4206 6471895 SGTC_773 4358-1457 44.6 µM -1.07467659668371 0.141092107564619 no 2879 0.141259772613675 4173 1186886 SGTC_397 arbidol 50 µM -1.07497961098982 0.141029000464782 no 2880 0.141191928423152 4212 131410 A RNA synthesis inhibitor. SGTC_3048 9093155 49.47 µM -1.07526039422602 0.140970540396528 no 2881 0.141129081440352 4144 25236002 SGTC_27 0485-0001 32.618 µM -1.07587107642713 0.140843450947788 no 2882 0.140992459529138 4113 2054479 SGTC_1291 0993-0025 5.79 µM -1.07779386736448 0.140443805542814 no 2883 0.140562878480667 4175 4353356 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.07804421168647 0.140391829050636 no 2884 0.140507013149299 4304 16725076 SGTC_3316 9136639 10.545 µM -1.08127322982111 0.13972259096094 no 2885 0.139787795912832 4184 4903665 SGTC_3224 9130643 49.47 µM -1.08216491406601 0.139538165549183 no 2886 0.139589627848285 4244 17644395 SGTC_275 trichlorophene 5.69 µM -1.08306633081793 0.139351895530311 no 2887 0.139389491100053 4228 62616 SGTC_2738 aclarubicin 5.55 µM -1.08442017537024 0.139072453162672 no 2888 0.139089271141426 4142 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_68 0986-0284 82.829 µM -1.08477252617713 0.138999788250384 no 2889 0.139011208302046 4231 423278 YIL048W NEO1 SGTC_2857 9024691 58.44 µM -1.08505873754896 0.138940782228168 no 2890 0.138947820521724 4272 16478292 SGTC_488 nitrendipine 139 µM -1.08586123818034 0.138775427732932 no 2891 0.13877019413015 4211 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1123 mangostin 811.285 nM -1.08698951675077 0.138543173769662 no 2892 0.138520721356116 4189 5281650 An antioxidant. SGTC_1489 4065-0444 182 µM -1.08951601712517 0.138024059527016 no 2893 0.13796319774938 4168 2877968 SGTC_382 3229-0966 23.2 µM -1.09211880288958 0.137490660044105 no 2894 0.137390442888807 4216 5722370 SGTC_889 0919-1524 82.7 µM -1.09622939168204 0.13665112992303 no 2895 0.136489200103109 4216 3905452 SGTC_2081 5214970 32.255 µM -1.09633649956601 0.136629301597207 no 2896 0.136465770978113 4152 2063512 SGTC_3233 9132340 49.47 µM -1.09888179805013 0.136111277457346 no 2897 0.135909813504532 4186 17682950 SGTC_2921 7974240 10.71 µM -1.10051865340123 0.135778852570818 no 2898 0.135553103404125 4280 2979074 YDR527W RBA50 SGTC_2645 abamectin 100 µM -1.10364058694584 0.13514636950256 no 2899 0.134874538845342 4155 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_846 0335-0850 148 µM -1.10743863672953 0.134379637433676 no 2900 0.134052164513573 4168 6819598 SGTC_1180 1193-0155 285 µM -1.10933374755326 0.133998180679934 no 2901 0.133643115852983 4281 2921347 SGTC_1020 4335-0961 93.3 µM -1.1105751354337 0.133748712028674 no 2902 0.133375635172372 4152 669075 SGTC_3264 9137442 49.47 µM -1.11172348472917 0.133518224813475 no 2903 0.133128529546584 4201 17015726 SGTC_3144 9087057 49.47 µM -1.11638721829758 0.132584966955814 no 2904 0.132128211151422 4104 17249618 SGTC_57 miconazole 162.5 nM -1.11738286690414 0.132386311643536 no 2905 0.131915328779536 4077 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2435 5706476 10.6 µM -1.11742942586397 0.132377027059302 no 2906 0.131905379673698 4194 5725375 SGTC_608 k048-0125 159 µM -1.11968809406942 0.131927152199992 no 2907 0.131423350181466 4246 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2439 5492030 7.2 µM -1.12479039087239 0.130914776919257 no 2908 0.130338933652095 4212 5722370 SGTC_3315 9136395 68.55 µM -1.12542604771755 0.13078902977093 no 2909 0.130204269208016 4214 16876844 SGTC_156 3474-0145 5.642 µM -1.12620533217333 0.130634983811686 no 2910 0.130039308531068 4045 2265471 SGTC_2074 5212007 75.395 µM -1.12777243635226 0.130325584568857 no 2911 0.129708018491224 4114 758611 SGTC_2478 5763493 32.33 µM -1.12944578754342 0.129995768636351 no 2912 0.129354913361356 4147 1365576 YLR208W SEC13 SGTC_1022 4477-0945 21.3 µM -1.12996910188123 0.129892742575044 no 2913 0.129244622140862 4171 4648966 SGTC_381 3461-2219 42.7 µM -1.13132920507047 0.129625240462254 no 2914 0.128958278227003 4221 2883159 SGTC_824 1304-0008 100 µM -1.13194965819067 0.129503337932035 no 2915 0.128827799836918 4239 768245 SGTC_111 0083-0039 52.457 µM -1.13426825987818 0.129048497486804 no 2916 0.128341019418147 4105 759313 SGTC_1819 st053448 58.6 µM -1.13448849238901 0.12900535211744 no 2917 0.128294849051722 4114 2857616 SGTC_635 k038-0028 24.7 µM -1.13785408046577 0.128347249906999 no 2918 0.127590709194239 4223 4035102 SGTC_130 0136-0219 337.655 µM -1.13871607426906 0.128179072490271 no 2919 0.127410798047616 4056 234244 SGTC_2743 auranofin 4.32 µM -1.13953838600297 0.128018779854474 no 2920 0.127239333656433 4225 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1527 coumarin 137 µM -1.13983093213112 0.127961787645146 no 2921 0.12717837211091 4305 323 A hepatotoxic, DNA x-linker. SGTC_2917 7979103 53.79 µM -1.13996406463256 0.12793585734913 no 2922 0.127150636333105 4258 2980565 SGTC_23 0213-0011 39.996 µM -1.14000458941555 0.127927965038034 no 2923 0.127142194554289 4240 627608 SGTC_2740 felodipine 17.08 µM -1.14461832419695 0.127031638610364 no 2924 0.126183649121895 4267 3333 L-type calcium channel blocker SGTC_2639 lactacystin 53 µM -1.14572639232313 0.126817022805287 no 2925 0.125954189983187 4283 3870 A proteasome inhibitor. SGTC_563 tetrahydrosecaminediol 614 µM -1.14787264728491 0.126402044462983 no 2926 0.125510570718755 4287 334274 A psychoactive constituent of the cannabis plant. SGTC_2622 2-methoxyxanthone 59.94 µM -1.15074079277897 0.125848966974514 no 2927 0.124919444514012 4235 71034 A hepatoprotective. SGTC_501 nsc-95397 161 µM -1.15078722428121 0.125840027282461 no 2928 0.124909890983995 4275 262093 SGTC_2828 7998861 71.43 µM -1.15190184330681 0.125625556967158 no 2929 0.124680705348541 4219 2988188 SGTC_1000 4048-0884 8.67 µM -1.15559828613483 0.124916128838618 no 2930 0.123922754691132 4293 13040088 SGTC_1655 st012546 55.1 µM -1.15933210665568 0.124202373440295 no 2931 0.123160419699639 4228 720985 YLR208W SEC13 SGTC_3055 9094636 49.47 µM -1.15954054326318 0.124162613042068 no 2932 0.123117960223186 4287 25236176 SGTC_1792 st045773 43.6 µM -1.16250222245997 0.123598618899769 no 2933 0.122515761225925 4203 2919270 SGTC_2375 9072683 200 µM -1.163003861817 0.123503269404601 no 2934 0.12241396779211 4337 16798029 SGTC_25 0118-0223 35.662 µM -1.16316729913214 0.123472215058654 no 2935 0.122380815662486 4258 5333628 SGTC_2126 5251174 33.877 µM -1.16323544482005 0.123459268470062 no 2936 0.12236699464232 4259 790722 SGTC_1002 4049-0206 172 µM -1.16712220613985 0.122722419410264 no 2937 0.121580510650597 4212 4662749 SGTC_1318 1280-3875 124 µM -1.17010107488355 0.122159779787141 no 2938 0.120980147988144 4261 373245 SGTC_3103 9120822 49.47 µM -1.17102137191243 0.121986323665674 no 2939 0.120795093341929 4262 17141819 SGTC_1754 st042065 16.137 µM -1.17212140282853 0.121779218632442 no 2940 0.120574159059733 4031 1126236 YIL048W NEO1 SGTC_1263 0774-1208 64.8 µM -1.17343459661672 0.121532304645853 no 2941 0.12031078512412 4304 906585 SGTC_7 0192-1582 4.227 µM -1.1748535280798 0.121265905051259 no 2942 0.120026660279435 4309 252616 SGTC_53 0973-0023 39.979 µM -1.17828473322273 0.120623405829186 no 2943 0.119341556021672 4155 674768 SGTC_2978 9011784 42.97 µM -1.17853312129764 0.120576987929205 no 2944 0.119292068031906 4238 2994934 SGTC_2598 perillyl alcohol 100 µM -1.17903756955003 0.120482757105764 no 2945 0.119191608067089 4300 10819 An apoptosis inducer. SGTC_1603 st002045 67.8 µM -1.17968875765246 0.120361192011164 no 2946 0.119062013445605 4271 5887985 SGTC_423 5-fluorouracil 457 µM -1.18071958174 0.120168932394859 no 2947 0.118857069933712 4196 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2944 9067346 25.62 µM -1.18154396650496 0.120015331708692 no 2948 0.118693349105102 4219 6473075 SGTC_2780 5215298 71.43 µM -1.18349965696637 0.119651498019238 no 2949 0.118305591195749 4291 2834131 SGTC_1331 1472-0049 76.2 µM -1.18468838027943 0.119430730231052 no 2950 0.118070339183515 4215 24051409 SGTC_2526 patulin 37.61 µM -1.19144528847107 0.11818130772995 no 2951 0.116739411420185 4312 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_112 phenothiazine 287.218 µM -1.1951393246501 0.117502163281845 no 2952 0.116016299942383 4239 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2313 7726885 200 µM -1.19595217198084 0.117353093851142 no 2953 0.115857611949207 4292 726423 SGTC_844 0330-0132 15.3 µM -1.19722695427832 0.117119579210388 no 2954 0.11560905328258 4317 2828079 SGTC_1916 st067606 49.2 µM -1.19739924354298 0.117088044531113 no 2955 0.115575489184896 4201 19590279 SGTC_183 3914-0051 30.55 µM -1.19749487811936 0.117070542812057 no 2956 0.115556861364797 4310 1596232 SGTC_923 1900-2434 73.3 µM -1.19947872491028 0.116707904558417 no 2957 0.115170926236399 4270 5910570 SGTC_645 0845-0943 5.41 µM -1.20283592347402 0.11609603946602 no 2958 0.11451991014466 4298 1885106 SGTC_2909 7941780 10.49 µM -1.20747465332214 0.115254360988421 no 2959 0.113624700343109 4276 1243215 SGTC_3139 9095020 49.47 µM -1.20840750283652 0.115085624460877 no 2960 0.113445277628663 4112 25236292 SGTC_2116 5511452 16.8835 µM -1.20855979267684 0.115058094520337 no 2961 0.113416005651335 4307 870744 SGTC_2799 7812892 81.82 µM -1.20858856447834 0.115052893872156 no 2962 0.113410475962822 4316 20205235 SGTC_683 panaxydol 45 µM -1.2086806789888 0.115036244834265 no 2963 0.113392773653089 4292 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3009 9080819 71.4286 µM -1.21088986852452 0.114637462825621 no 2964 0.112968808036879 4318 17027216 SGTC_2794 7785382 27.27 µM -1.21328153352166 0.11420685217389 no 2965 0.112511100342171 4286 2205081 SGTC_2339 9000433 200 µM -1.21707207231935 0.113526741161463 no 2966 0.111788397687227 4312 2988954 SGTC_2003 4023581 200 µM -1.21883389971492 0.113211613270078 no 2967 0.111453621023667 4314 16641307 SGTC_1794 st048918 76.9 µM -1.22501561059168 0.112110863954913 no 2968 0.110284669431119 4232 672303 SGTC_1594 piperine 70.1 µM -1.22504156577849 0.112106258417785 no 2969 0.110279779953787 4286 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2374 9071832 200 µM -1.22552746426871 0.112020064640676 no 2970 0.110188274357267 4238 17381698 SGTC_3309 9129340 25.759 µM -1.22650639936826 0.111846554761343 no 2971 0.110004084312594 4323 17158987 SGTC_1490 4089-0339 670 nM -1.22790403487408 0.111599166184723 no 2972 0.109741497340645 4282 742542 SGTC_414 piperonyl butoxide 100 µM -1.22818886352179 0.111548798128607 no 2973 0.10968803913257 4307 5794 A potent inhibitor of cytochrome P450. SGTC_41 0478-0632 82.643 µM -1.22842752878383 0.111506605963853 no 2974 0.109643259520478 4279 3750424 SGTC_2217 6934799 96.0675 µM -1.22995637823441 0.11123660094063 no 2975 0.109356720184328 4280 675606 SGTC_1276 0871-0068 94.2 µM -1.23491989743072 0.110363237824635 no 2976 0.108430158703956 4328 3414906 SGTC_3106 9121286 49.47 µM -1.23644695577466 0.110095533786704 no 2977 0.108146235649822 4279 15943471 SGTC_69 0096-0274 206.684 µM -1.23823249779253 0.1097831069332 no 2978 0.107814932426961 4425 6741392 SGTC_2534 helenine 20.12 µM -1.24065602567234 0.109360066744243 no 2979 0.107366422812489 4343 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_216 k038-0035 28.382 µM -1.24072418983928 0.109348185266297 no 2980 0.107353827502638 4239 4444231 YPR107C YTH1 SGTC_1875 nocodazole 6 µM -1.24082281575255 0.109330995740277 no 2981 0.107335605385867 4344 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2693 st077581 40.7 µM -1.24171695184852 0.10917524518553 no 2982 0.107170506596396 4325 25238761 SGTC_1632 st005650 90 µM -1.24262100575181 0.109017929197532 no 2983 0.107003762782591 4348 2759605 SGTC_2246 7293507 91.5585 µM -1.24628414265754 0.108382168053246 no 2984 0.106330048703293 4382 887656 SGTC_1057 3448-5381 134 µM -1.24922082888382 0.107874417177024 no 2985 0.105792157871465 4308 5497911 SGTC_2691 st077356 60.2 µM -1.24994420346506 0.1077496096424 no 2986 0.105659965208329 4341 2839272 SGTC_2847 9005661 71.43 µM -1.25137409535325 0.107503209144797 no 2987 0.105399011904551 4364 2991449 SGTC_883 0850-0245 24.6 µM -1.25290740165566 0.107239439642547 no 2988 0.105119703947954 4399 6823229 YPR165W RHO1 SGTC_1420 4'-methoxyflavone 42 µM -1.25498771480863 0.106882316887103 no 2989 0.104741609870697 4313 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1768 st044301 37.178 µM -1.25546494476781 0.106800513008631 no 2990 0.104655013026637 4335 3931349 SGTC_656 4090-1979 187 µM -1.2571130053049 0.106518359839388 no 2991 0.104356359245068 4360 22330961 SGTC_1464 k208-0027 110 µM -1.2583207870259 0.106311925762313 no 2992 0.104137883221984 4334 X1464 SGTC_862 0452-0056 10.2 µM -1.25974170302047 0.106069432868809 no 2993 0.103881278029607 4295 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_689 0833-0039 98 µM -1.2603611693221 0.105963840206588 no 2994 0.103769551412488 4283 5374726 SGTC_1480 1070-0044 41.2 µM -1.26235320166906 0.105624798340348 no 2995 0.103410860422302 4365 3124987 SGTC_2644 guaiazulene 100 µM -1.26517939324118 0.105145130309194 no 2996 0.102903513827831 4349 3515 A coloring agent. SGTC_186 3455-3465 67.277 µM -1.26687946135553 0.104857351072333 no 2997 0.102599196840235 4350 755278 SGTC_3080 9117754 49.47 µM -1.27284572739672 0.103851923894358 no 2998 0.101536395549885 4338 9550191 SGTC_3021 9087658 49.47 µM -1.27742285612125 0.103085345713705 no 2999 0.100726499871967 4345 25237042 SGTC_1654 st012436 41.8 µM -1.28186711417637 0.102344961300734 no 3000 0.0999446329381478 4360 4323132 SGTC_2221 6807166 181.081 µM -1.28407124535504 0.101979205292022 no 3001 0.0995585140484641 4319 674925 SGTC_2960 9079389 5.97 µM -1.29269256639111 0.100557710346333 no 3002 0.0980587048961199 4343 16457355 SGTC_2008 4012253 172 µM -1.29578253192059 0.10005176788222 no 3003 0.0975252089175716 4349 603940 SGTC_110 0850-0284 111.64 µM -1.29956088818242 0.0994356393386045 no 3004 0.096875756039258 4224 3906265 SGTC_1756 st041558 35.5 µM -1.30038470420417 0.0993016704600871 no 3005 0.0967345748520253 4451 3955792 SGTC_813 k007-0158 173 µM -1.30339325095084 0.0988135418753451 no 3006 0.096220269732728 4372 6523916 SGTC_159 3970-0959 50 µM -1.30536277717987 0.0984949439214891 no 3007 0.0958846734566213 4422 6615653 SGTC_2037 5169046 200 µM -1.30598426514221 0.0983945659725974 no 3008 0.0957789542750493 4421 5718022 SGTC_1561 5-methoxyflavone 52.9 µM -1.30854001163239 0.0979825688916491 no 3009 0.0953451063199526 4337 94525 SGTC_1877 wortmannin 25 µM -1.3098862982762 0.0977660508556318 no 3010 0.0951171515058758 4380 312145 A covalent inhibitor of PI 3-kinase. SGTC_818 4072-2707 53.5 µM -1.31679598907106 0.096660310216109 no 3011 0.0939535088351822 4290 882871 SGTC_3183 9108214 49.47 µM -1.32093150891623 0.0960029226420851 no 3012 0.093262101236752 4360 4974831 SGTC_1556 plumbagin 1.48 µM -1.32120449571823 0.0959596442638936 no 3013 0.093216593853347 4305 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3125 9127534 49.47 µM -1.32599568071867 0.095202400693223 no 3014 0.0924205640396643 4276 1639235 SGTC_3100 9120536 49.47 µM -1.32616504528024 0.0951757134919386 no 3015 0.0923925173540875 4269 16421196 SGTC_1496 4469-0713 57.4 µM -1.3267406930479 0.0950850484044834 no 3016 0.0922972374584806 4359 746691 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.32676702921315 0.0950809019549005 no 3017 0.0922928800972063 4409 94937 An inhibitor of serotonin biosynthesis. SGTC_1854 st056233 32.9 µM -1.32713416038969 0.0950231135230788 no 3018 0.0922321535019936 4306 5393174 SGTC_1620 st003704 16.5 µM -1.32997472630223 0.0945768673440762 no 3019 0.0917632993020364 4361 2834414 SGTC_1498 4478-3555 97.6 µM -1.3323541916509 0.0942042496003243 no 3020 0.0913719136725907 4373 3437919 SGTC_935 2996-0153 430 µM -1.33255736591916 0.0941724833193883 no 3021 0.0913385520457669 4397 23738523 SGTC_1828 st055811 49 µM -1.33400327962779 0.0939466430186711 no 3022 0.0911013908525705 4402 5877589 SGTC_2103 5378138 10 µM -1.33408300511293 0.0939342021645296 no 3023 0.0910883274423109 4464 244142 SGTC_996 3970-0799 1.8 µM -1.3385199201365 0.0932437540069057 no 3024 0.0903635055845812 4373 6615648 YGL040C HEM2 SGTC_3004 9076122 71.4286 µM -1.33982684332273 0.0930410945789667 no 3025 0.0901508232233306 4403 44782551 SGTC_163 TUB2.036 7.546 µM -1.34117796903154 0.0928319233076342 no 3026 0.0899313387355588 4342 15992207 YJR013W GPI14 SGTC_309 k408-0051 1.48 µM -1.34451925795148 0.0923161432376873 no 3027 0.0893902666273986 4312 3640463 SGTC_2551 apiole 73.87 µM -1.34541893151778 0.0921776276835249 no 3028 0.0892449924908174 4309 10659 A possible DNA adduct former. SGTC_1499 4480-0877 67.3 µM -1.34933061682895 0.0915771651711661 no 3029 0.0886153978521449 4386 2861909 SGTC_3176 9106582 49.47 µM -1.34934259707539 0.0915753306086829 no 3030 0.0886134746992129 4386 17018027 SGTC_447 ml7 120 µM -1.35409563818158 0.0908496335401625 no 3031 0.0878529338043105 4458 4216 Selective myosin light chain kinase inhibitor. SGTC_2463 5473429 200 µM -1.35528425230028 0.0906688240054953 no 3032 0.0876635051624733 4402 5399405 SGTC_1162 k048-0130 20.1 µM -1.3553695891118 0.0906558530285884 no 3033 0.0876499168254753 4375 6797406 SGTC_248 streptozotocin 5.23457 mM -1.35596859548734 0.0905648443543883 no 3034 0.0875545801692452 4430 5300 DNA alkylating agent. SGTC_2150 5556613 200 µM -1.35647114670247 0.0904885427106811 no 3035 0.0874746548362201 4437 743190 SGTC_1040 k898-0338 155 µM -1.36089702949718 0.0898186271677706 no 3036 0.086773116202635 4397 20969351 SGTC_2620 irigenin 100 µM -1.36655102065195 0.0889681931133358 no 3037 0.0858830392011501 4408 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_757 1066-0008 322 µM -1.36814305916529 0.088729814726799 no 3038 0.0856336503940892 4438 6842497 SGTC_1717 st033143 58.0435 µM -1.37198201494413 0.0881569587938363 no 3039 0.0850345183566165 4460 674616 SGTC_152 4469-0003 551.229 µM -1.37634945248794 0.087508599517259 no 3040 0.0843567346754908 4399 697280 SGTC_974 1326-0144 138 µM -1.37655361823552 0.0874783777959297 no 3041 0.084325149616063 4443 5411856 SGTC_3180 9109287 49.47 µM -1.3786513031974 0.0871683181385789 no 3042 0.0840011452542684 4450 18891271 SGTC_2493 resveratrol 26.09 µM -1.38029425588037 0.0869260462909512 no 3043 0.083748031423365 4354 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1652 st011932 78 µM -1.38155800011163 0.0867400355358122 no 3044 0.0835537287243604 4356 1551076 SGTC_845 0330-0138 4.51 µM -1.38524702083031 0.0861987494701404 no 3045 0.0829884736739815 4366 9039800 SGTC_1842 st055362 61.2 µM -1.38755297971649 0.0858616842365562 no 3046 0.0826366039297481 4377 676032 SGTC_104 0074-0074 590.992 µM -1.39054558203827 0.0854257234237557 no 3047 0.0821816339260397 4276 3943124 SGTC_2316 5844804 197.44 µM -1.39189362281046 0.0852298840205446 no 3048 0.08197730663338 4435 776813 SGTC_279 1273-0055 2.93 µM -1.39191563899562 0.0852266883679974 no 3049 0.0819739727423882 4460 2847562 SGTC_968 1309-0633 340 µM -1.39295128649618 0.085076465398905 no 3050 0.0818172609894792 4462 3761976 SGTC_1427 4048-4900 550 nM -1.40561498142888 0.0832555870434473 no 3051 0.0799192424718555 4423 24132586 SGTC_1138 3761-0006 1.03 µM -1.40570618806112 0.0832425798065702 no 3052 0.0799056943457396 4470 12061087 SGTC_368 fentichlor 4.58 µM -1.40831895851415 0.0828706136751818 no 3053 0.0795183221533221 4444 7329 A pesticide. SGTC_3292 9120825 59.784 µM -1.40976572419229 0.0826651840367509 no 3054 0.079304435296223 4416 24824900 SGTC_352 k048-0007 5.11 µM -1.41179033569831 0.0823783484763733 no 3055 0.0790058524538253 4376 6811911 SGTC_1157 4092-0394 27.6 µM -1.41656026385633 0.0817055354239559 no 3056 0.0783057665494799 4503 3659885 SGTC_2320 7373003 200 µM -1.41861865497051 0.0814164758656187 no 3057 0.0780051120836159 4444 5415828 SGTC_1872 amphotericin b 148 nM -1.41954929111065 0.0812860402457896 no 3058 0.077869468570654 4450 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.42197713770482 0.0809465015289871 no 3059 0.0775164440106984 4468 77254 SGTC_103 0844-0104 51.839 µM -1.42727923246802 0.0802087175640064 no 3060 0.0767497121083194 4277 5375804 SGTC_43 0570-0105 72.5 µM -1.42977493547952 0.0798632058809879 no 3061 0.0763908125172738 4420 1114046 YDL195W SEC31 SGTC_1570 verbenone 133 µM -1.43270005878388 0.0794596782700367 no 3062 0.0759717863506714 4471 29025 A natural terpanoid with antifungal properties. SGTC_3202 9113761 49.47 µM -1.43600443701889 0.0790056898156589 no 3063 0.0755005393527346 4385 4798415 SGTC_2814 7977482 42.97 µM -1.43635734160631 0.0789573206099266 no 3064 0.0754503425452535 4456 6456762 SGTC_3322 9139058 2.11 µM -1.4398064985988 0.0784857584690491 no 3065 0.0749610760495872 4495 4908926 YPR165W RHO1 SGTC_1508 1080-0625 72.9 µM -1.44407794641255 0.0779047372581425 no 3066 0.0743585254070094 4387 767111 SGTC_3128 9127691 49.47 µM -1.44427029252007 0.0778786504971505 no 3067 0.0743314794260153 4479 41316314 SGTC_225 nsc-122657 1.016 µM -1.44445752536026 0.0778532635858889 no 3068 0.0743051596421485 4472 275685 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.44583519669384 0.0776666581418353 no 3069 0.0741117157584142 4492 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3158 9100007 49.47 µM -1.44621025186063 0.0776159158070598 no 3070 0.0740591195654395 4482 19297233 SGTC_759 3486-0358 89.3 µM -1.44672361137618 0.0775465026724076 no 3071 0.073987174374196 4451 875103 SGTC_2829 7992743 58.44 µM -1.45203711877024 0.0768308112775284 no 3072 0.0732456422657245 4440 16462845 SGTC_2057 5236571 38.335 µM -1.45895274380154 0.0759068614043912 no 3073 0.0722890573372001 4417 54684039 YBR257W POP4 SGTC_1222 0366-0074 1.18 µM -1.45931733573333 0.0758583865665353 no 3074 0.0722388930845726 4488 286520 SGTC_2211 7117706 200 µM -1.4599584220125 0.0757732072080947 no 3075 0.0721507506424636 4421 822771 SGTC_2843 9000894 45.46 µM -1.46064757819458 0.0756817222052473 no 3076 0.0720560910719009 4455 2242070 SGTC_1641 st009299 47.1 µM -1.46328615488236 0.0753322306812769 no 3077 0.0716945472868875 4398 4046054 SGTC_109 0132-0036 33.701 µM -1.46331721591759 0.0753281238441757 no 3078 0.0716902995357324 4365 67274 A color developer. SGTC_1824 st053723 68.6 µM -1.46361443188461 0.0752888350851642 no 3079 0.0716496635347108 4489 675225 SGTC_3136 9095672 49.47 µM -1.46619142202969 0.0749488392968881 no 3080 0.0712980724259201 4346 17217380 SGTC_3226 9131256 49.47 µM -1.46935216202423 0.0745334269699857 no 3081 0.0708686477348037 4478 17178073 SGTC_602 3130-1533 38.1 µM -1.47049951690473 0.0743830670367139 no 3082 0.0707132582124663 4523 720941 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.47384069399963 0.0739465276347409 no 3083 0.0702622443629174 4491 140250 A respiratory chain inhibitor. SGTC_129 0088-0017 176.636 µM -1.476960327496 0.0735407036270854 no 3084 0.0698431360393836 4342 182446 SGTC_383 2324-0395 7.37 µM -1.47704739959248 0.0735294011513586 no 3085 0.0698314659660375 4466 3146421 SGTC_1691 st019933 84.6 µM -1.47875311072856 0.0733082574901285 no 3086 0.0696031559511908 4466 6176082 SGTC_997 3996-0078 137 µM -1.48169180041459 0.072928453298678 no 3087 0.0692111599211287 4537 735687 SGTC_896 0964-0007 44.5 µM -1.48326099860589 0.0727262637261202 no 3088 0.0690025401091805 4433 6756758 SGTC_852 0418-0143 439 µM -1.48623416619282 0.0723443516177882 no 3089 0.0686085966439445 4475 5369229 SGTC_1351 1496-0003 46.5 µM -1.48657998958249 0.0723000295425299 no 3090 0.0685628880339573 4507 3891978 SGTC_1491 4138-0063 26.5 µM -1.4869287501487 0.0722553521044918 no 3091 0.0685168150003381 4497 23883227 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.48743153909399 0.0721909803388472 no 3092 0.0684504360775333 4481 115019 SGTC_1895 st058434 18.3 µM -1.49077489604309 0.0717640497588824 no 3093 0.0680103024000067 4480 5393175 SGTC_2370 9071495 200 µM -1.49922031953976 0.0706942356246469 no 3094 0.0669082426707097 4497 21791103 SGTC_272 doxorubicin 8.13 µM -1.50839211139258 0.069546337256144 no 3095 0.0657271004046618 4533 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_734 2023-0417 80 µM -1.50865787042448 0.0695132913422145 no 3096 0.0656931185175881 4508 3935732 SGTC_228 caffeine 993.056 µM -1.51051614064998 0.0692825617517649 no 3097 0.065455886999266 4489 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1978 st071761 42 µM -1.51143785002633 0.0691683380701152 no 3098 0.0653384660029307 4500 5147680 SGTC_848 0368-0089 85.6 µM -1.51266460326106 0.0690165366971622 no 3099 0.0651824375465581 4493 762535 SGTC_266 formosanin C 406 nM -1.51586475882405 0.0686217503871014 no 3100 0.0647767764970701 4355 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1379 2144-0755 36.5 µM -1.51753560796035 0.068416319796239 no 3101 0.0645657551844724 4552 5392327 SGTC_1882 5615643 20 µM -1.51893767416371 0.0682443024267584 no 3102 0.0643890924231888 4479 2253075 SGTC_1980 st071811 45.7 µM -1.52409218631622 0.0676147713520456 no 3103 0.0637428421572899 4565 4974850 SGTC_545 4218-0007 221 µM -1.52590058697196 0.0673949740487495 no 3104 0.0635173122502011 4509 2840508 SGTC_3312 9133330 71.43 µM -1.52691521342556 0.0672718960195243 no 3105 0.0633910480191906 4515 17617324 SGTC_1690 st023502 41.2 µM -1.52795402730807 0.0671460640658182 no 3106 0.0632619763131547 4510 24207482 SGTC_937 3122-0005 46.7 µM -1.53456876644193 0.066349082849666 no 3107 0.0624448948288428 4500 759535 SGTC_3157 9099274 49.47 µM -1.53677189252901 0.0660852701359294 no 3108 0.0621745893721844 4526 17217662 SGTC_907 3448-6986 75.5 µM -1.53725656758462 0.0660273420564823 no 3109 0.0621152463949318 4520 590582 SGTC_2284 7945075 39.21 µM -1.53819117194409 0.0659157497744205 no 3110 0.062000939434921 4473 1245402 SGTC_299 1273-0059 1.44 µM -1.54831349925561 0.0647164828161399 no 3111 0.0607734179439163 4298 2848077 SGTC_1710 st031758 61.5 µM -1.54960110150019 0.064565153687082 no 3112 0.0606186442134524 4545 5394341 SGTC_415 dibenzyl ketone 100 µM -1.55064668631496 0.0644424706973286 no 3113 0.0604931887118629 4501 7593 SGTC_453 enantio-paf c16 10 µM -1.55143075029994 0.0643505919699905 no 3114 0.0603992453957341 4152 13871343 A lipid and platelet activating factor SGTC_430 0958-0115 16.4 µM -1.55263861648432 0.064209250199621 no 3115 0.0602547473011709 4454 6833180 SGTC_294 k038-0071 157 µM -1.55455769965643 0.063985179836355 no 3116 0.0600257223621156 4550 24152826 SGTC_1675 st018485 24.5 µM -1.55548477755652 0.0638771531217015 no 3117 0.0599153286046029 4519 3323024 SGTC_475 α-linolenic acid 10 µM -1.56081267745297 0.0632590733302182 no 3118 0.0592839776783941 4516 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2492 derrusnin 100 µM -1.56233400287309 0.063083444525781 no 3119 0.059104662832214 4549 1715307 Part of coumarin class of compounds. SGTC_1769 st044406 64.4 µM -1.56742137206232 0.0624988925670595 no 3120 0.0585081158163 4511 670903 SGTC_2813 7971799 71.43 µM -1.56910749076923 0.0623060876836011 no 3121 0.0583114473262242 4521 2234054 SGTC_1958 st076513 41.9 µM -1.57540260559477 0.0615903482547061 no 3122 0.0575817716793095 4460 732122 YGL099W LSG1 SGTC_2761 levamisole 97.89 µM -1.57828710828841 0.0612645396965044 no 3123 0.0572498331104585 4533 26879 An alkaline phosphatase inhibitor. SGTC_2721 ifenprodil 61.44 µM -1.58490550087366 0.0605220734346175 no 3124 0.056493903261614 4523 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_29 0299-0004 12.984 µM -1.58578387010156 0.0604240673927112 no 3125 0.0563941729491308 4450 16871 A napthoquinone isolated from Swertia calycina. SGTC_1991 st073000 8.92 µM -1.58976692003743 0.0599812071421032 no 3126 0.0559436764797083 4562 4301969 YIL048W NEO1 SGTC_1619 st003326 88.7 µM -1.59312821044995 0.0596094591696671 no 3127 0.0555657159609461 4512 2849032 SGTC_224 benfluorex 43.875 µM -1.59697918070704 0.059185776099201 no 3128 0.0551351740447445 4548 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3013 9080133 71.4286 µM -1.59753662098656 0.059124642776283 no 3129 0.0550730706618988 4586 17050193 SGTC_2158 5657123 3.6195 µM -1.5990030262356 0.0589640616434075 no 3130 0.0549099650906387 4544 2858827 SGTC_1815 st051655 58.2 µM -1.60078312345547 0.0587695891799246 no 3131 0.0547124813990001 4499 5984156 SGTC_1606 st000094 49.2 µM -1.60250495962744 0.0585819609295826 no 3132 0.054521995840273 4562 1242210 SGTC_2808 7946468 45.46 µM -1.60378155478192 0.058443154378699 no 3133 0.0543811058747978 4523 2970879 SGTC_598 3937-0236 20.2 µM -1.60537449159984 0.0582703137758419 no 3134 0.0542057072983583 4599 1379313 SGTC_2479 5617353 43.85 µM -1.60825495359608 0.0579587908568785 no 3135 0.0538896760130242 4567 2731746 SGTC_2143 5623677 140.463 µM -1.61121545778502 0.057639976953027 no 3136 0.0535663848991696 4517 5375313 SGTC_2670 beta-carotene 100 µM -1.61341375805712 0.0574041375703653 no 3137 0.0533273230435515 4542 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_561 1550-0330 72.9 µM -1.61580609723504 0.0571483445577293 no 3138 0.0530681214421801 4515 6812934 SGTC_3230 9131665 49.47 µM -1.61671313450221 0.0570515974623815 no 3139 0.0529701087005578 4581 15943720 SGTC_2328 6201408 200 µM -1.61826216770804 0.0568866714946185 no 3140 0.0528030550945801 4511 2890418 SGTC_3240 9133527 49.47 µM -1.61995851362604 0.0567064920594523 no 3141 0.0526205944925872 4543 17617455 SGTC_3344 9148862 3.898 µM -1.63102389907837 0.0555421763138784 no 3142 0.0514426383876429 4587 4905352 SGTC_1272 0839-0021 27 µM -1.63331979932081 0.0553029789092561 no 3143 0.0512008773797057 4604 5027250 SGTC_2077 5212015 200 µM -1.63396836087694 0.0552355563679202 no 3144 0.0511327470880363 4480 780900 SGTC_2080 5212524 12.4 µM -1.63457028115189 0.0551730406196981 no 3145 0.0510695809486658 4526 260183 SGTC_3024 9090631 49.47 µM -1.63855260849972 0.0547608410993448 no 3146 0.0506532345584363 4541 25236383 SGTC_1643 st009866 20.2 µM -1.63873384484783 0.054742139908591 no 3147 0.0506343510753906 4548 3156273 YOR207C RET1 SGTC_2970 9090938 41.86 µM -1.64069087403426 0.0545405218792453 no 3148 0.0504308001326216 4591 17217104 SGTC_2647 atorvastatin 60.16 µM -1.64081998935136 0.0545272407745363 no 3149 0.0504173937861686 4553 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_295 k015-0027 31 µM -1.64233035986656 0.0543720704015988 no 3150 0.0502607792856848 4607 3887424 SGTC_259 usnic acid 108.925 µM -1.64341835254687 0.0542605103062541 no 3151 0.0501482027648984 4595 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3228 9131799 49.47 µM -1.64350375708316 0.0542517608070478 no 3152 0.0501393743228071 4588 17015818 SGTC_418 lividomycin a 100 µM -1.64749016827708 0.053844602820931 no 3153 0.0497286677086578 4588 72394 An antibiotic. SGTC_411 enrofloxacin 100 µM -1.65312764834245 0.0532729452109233 no 3154 0.0491524437222453 4605 71188 A bacterial gyrase inhibitor. SGTC_83 0170-0301 39.027 µM -1.65860123501093 0.0527225203079357 no 3155 0.0485980863831294 4594 3089716 SGTC_1061 3448-9325 110 µM -1.65911582366273 0.0526710060866815 no 3156 0.0485462276410835 4544 723482 SGTC_3014 9081533 49.47 µM -1.65957136817715 0.0526254359677958 no 3157 0.048500356126105 4585 21367265 SGTC_1553 gossypol 38.6 µM -1.65980880711111 0.0526016963154965 no 3158 0.0484764607171235 4509 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3034 9090421 49.47 µM -1.66509793740567 0.0520750778090233 no 3159 0.0479466090887121 4517 17173761 SGTC_281 1672-3440 14.9 µM -1.66539927454535 0.0520452013826032 no 3160 0.0479165620317858 4609 6833000 SGTC_2107 5363541 170.161 µM -1.66584389354927 0.0520011439770378 no 3161 0.0478722555228303 4517 244052 SGTC_2651 TUB2.036 5 µM -1.66744748474218 0.0518424898449302 no 3162 0.0477127292514716 4462 15992207 YFL037W TUB2 SGTC_2457 5731572 11.68 µM -1.67239709352688 0.0513552166492772 no 3163 0.0472230224313443 4616 2865357 SGTC_2801 7907800 81.82 µM -1.67391904787623 0.0512061196327776 no 3164 0.047073255061911 4549 6620925 SGTC_969 1313-0238 134 µM -1.67422504621164 0.0511761843804574 no 3165 0.0470431894358887 4597 5212874 SGTC_802 4112-3352 742 µM -1.67495387459689 0.051104940525321 no 3166 0.0469716409839715 4604 704594 SGTC_2271 7849410 118.62 µM -1.68023868803973 0.0505907020116865 no 3167 0.0464554424047362 4520 972430 SGTC_1012 4112-3522 18 µM -1.68651664277717 0.0499851916310867 no 3168 0.0458481661371039 4579 3112398 SGTC_1423 4048-0112 5.59 µM -1.68690366800172 0.0499480528893672 no 3169 0.0458109383378196 4627 X1423 SGTC_1302 1159-0335 255 µM -1.69036821813306 0.0496165758260259 no 3170 0.0454787657124763 4617 649284 SGTC_2205 7238770 200 µM -1.69887797682297 0.0488098384252208 no 3171 0.0446710886864892 4620 279867 SGTC_2891 9063876 19.48 µM -1.69950732555843 0.048750594003626 no 3172 0.0446118177428643 4618 6472478 SGTC_3219 9131112 49.47 µM -1.70161088293232 0.0485529903681212 no 3173 0.0444141680254134 4457 17612988 YMR079W SEC14 SGTC_742 0kpi-0133 140 µM -1.70260127379556 0.0484601771898398 no 3174 0.0443213557722116 4619 2728852 SGTC_1797 st048695 56.8 µM -1.70775859421137 0.0479791565238934 no 3175 0.0438405724468481 4553 592262 YIL048W NEO1 SGTC_1382 3002-2117 298 µM -1.71338449877367 0.0474587975488909 no 3176 0.0433209130846509 4630 1497314 SGTC_3340 9146634 11.102 µM -1.7147454200207 0.0473336029468429 no 3177 0.0431959561180593 4582 4907387 SGTC_2763 lisinopril 49.32 µM -1.71682097028807 0.0471431775641965 no 3178 0.0430059440823603 4500 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1801 st050089 28.441 µM -1.72396656333579 0.0464922838113242 no 3179 0.0423569397654129 4632 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_673 1082-0474 110 µM -1.72398025217394 0.0464910438497113 no 3180 0.0423557041117909 4574 3098046 SGTC_2340 7987427 183.45 µM -1.73296125324023 0.0456832314456092 no 3181 0.0415512779284132 4585 2239331 SGTC_1034 k072-0165 12.7 µM -1.74820237058438 0.0443381961453997 no 3182 0.0402144956346878 4611 5835461 SGTC_2475 5812728 15.03 µM -1.75646328300853 0.0436226133283297 no 3183 0.0395046677604076 4569 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2048 5246248 200 µM -1.75752665904765 0.0435311816755298 no 3184 0.0394140409609103 4632 677046 SGTC_2186 6124449 200 µM -1.7632675000057 0.0430402385748451 no 3185 0.0389276919978038 4621 3834182 YLR033W RSC58 SGTC_1983 st071813 46.9 µM -1.76718975489136 0.0427073959577941 no 3186 0.0385982274471339 4657 11838595 SGTC_808 0711-0032 135 µM -1.77430984427049 0.0421085040338829 no 3187 0.0380059565605183 4591 4252555 SGTC_1688 st021091 57.6 µM -1.77677578690553 0.0419026778152396 no 3188 0.0378025686004894 4657 3656366 SGTC_3178 9107506 49.47 µM -1.78829523901969 0.0409519428057974 no 3189 0.036864193791862 4601 8897194 SGTC_70 0141-0289 43.283 µM -1.79288947541071 0.0405776807063971 no 3190 0.0364952992714594 4585 352408 SGTC_2372 9071633 200 µM -1.79384009672981 0.040500587599749 no 3191 0.0364193474878166 4661 21321366 SGTC_725 1497-0963 19 µM -1.79441163266033 0.0404542946728308 no 3192 0.0363737457858514 4664 3549977 SGTC_1198 1612-1005 86.7 µM -1.79464292535303 0.0404355727800399 no 3193 0.0363553046950468 4671 6998509 SGTC_1753 st043925 64 µM -1.79529215198434 0.0403830589797831 no 3194 0.0363035823895243 4645 670181 SGTC_2650 prasterone 100 µM -1.80382274162555 0.0396981787239581 no 3195 0.0356295497641202 4651 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2941 9056145 11.23 µM -1.80459808487653 0.039636401164839 no 3196 0.0355687989944611 4586 2119517 SGTC_2078 5212016 200 µM -1.80838184355478 0.0393360407977661 no 3197 0.0352735458882962 4544 1899708 SGTC_1923 st058458 19.1 µM -1.81490149508155 0.0388228478066629 no 3198 0.0347695243780934 4602 3534982 SGTC_1679 SEC14.276 6.7 µM -1.81509932723184 0.0388073611471417 no 3199 0.0347543232875791 4583 1005053 YMR079W SEC14 SGTC_2638 epoxomicin 18 µM -1.81610306332443 0.0387288643791393 no 3200 0.0346772819505174 4598 9915668 A protesome inhibitor. SGTC_1796 st049173 110.4 µM -1.82084179564729 0.0383600188317704 no 3201 0.0343154544525603 4619 94134 SGTC_530 4358-1714 28 µM -1.8220575630812 0.038265850993286 no 3202 0.03422312594684 4625 1564641 SGTC_1810 st050138 53 µM -1.83026922499935 0.0376347382867558 no 3203 0.0336048454306937 4646 3444541 SGTC_2583 asiatic acid 100 µM -1.84020592306718 0.0368824370331708 no 3204 0.0328690053666547 4614 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_788 1182-0090 188 µM -1.84169057789455 0.0367710978138199 no 3205 0.032760211600057 4629 5715185 SGTC_1798 st045719 60.953 µM -1.84408161799907 0.0365923636639702 no 3206 0.0325856232019066 4621 3980186 SGTC_261 5-fluorouridine 15.376 µM -1.84941996993843 0.0361958773768776 no 3207 0.0321985970215419 4644 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1143 3454-2408 5.08 µM -1.86186128108564 0.0352854855560036 no 3208 0.0313113229532164 4664 X1143 SGTC_1208 2323-2347 50.3 µM -1.86436207304751 0.0351047765534161 no 3209 0.0311354376149569 4648 5412760 SGTC_1878 temozolomide 1 mM -1.86856275569746 0.0348029417917675 no 3210 0.0308418357503602 4619 5394 DNA alkylating agent. SGTC_2678 equilin 100 µM -1.86877610454816 0.034787668913922 no 3211 0.0308269853418393 4656 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1343 1487-0095 224 µM -1.87969003504186 0.0340136907970164 no 3212 0.0300751672339606 4634 4560101 YGL055W OLE1 SGTC_1414 3917-0015 5.4 µM -1.88276836890509 0.0337979645800801 no 3213 0.029865882729797 4661 6618702 SGTC_2050 5263056 171 µM -1.88642774172676 0.0335429855211856 no 3214 0.02961866856448 4624 763468 YGL055W OLE1 SGTC_3038 9091290 49.47 µM -1.89137370555516 0.0332008773641447 no 3215 0.0292872380271803 4645 25236843 SGTC_2458 5808907 16.39 µM -1.89839787685669 0.0327199655087725 no 3216 0.0288218445502681 4729 2731747 SGTC_1113 artemisinin 1.17947 µM -1.90222142720687 0.0324606085899188 no 3217 0.0285711063541102 4678 2240 An anti-malaria and mitochondrial poison. SGTC_812 4251-0442 148 µM -1.91117767231825 0.0318597282441834 no 3218 0.0279908760884597 4672 5723007 SGTC_2483 5729050 27.16 µM -1.91216479723926 0.0317940671635487 no 3219 0.0279275299013398 4635 2865180 SGTC_1247 0448-0043 5.84 µM -1.91540332410754 0.0315794330512957 no 3220 0.0277205437788287 4625 3089013 YGL099W LSG1 SGTC_1645 Cervolide 78 µM -1.9179793917015 0.0314095599712751 no 3221 0.0275568121542139 4692 23173 A fragrance. SGTC_713 1488-1073 324 µM -1.92048044411771 0.0312453571290608 no 3222 0.0273986204973477 4691 3312542 SGTC_1370 2001-0092 44.6 µM -1.92504428994601 0.0309475545955565 no 3223 0.0271119087983264 4628 790957 SGTC_325 2810-4341 181 µM -1.93565677611838 0.0302641371340254 no 3224 0.0264548758297903 4676 774970 SGTC_1346 1488-2224 62.4 µM -1.94398935756324 0.0297363474785714 no 3225 0.0259483672418425 4678 3722427 SGTC_939 1165-0479 45.3 µM -1.94877945484009 0.0294364129271277 no 3226 0.0256608841628581 4656 1377347 SGTC_1998 st075797 76.8 µM -1.95101517415499 0.0292972842888119 no 3227 0.025527620368746 4667 24208315 SGTC_464 bw-b 70c 158 µM -1.95157531334571 0.0292625125521266 no 3228 0.0254943232707123 4662 5353454 SGTC_280 3448-3607 3.04 µM -1.95483042203239 0.0290611230318063 no 3229 0.0253015445641024 4650 626179 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.95550432649695 0.0290195736200632 no 3230 0.0252617866011693 4620 17037758 SGTC_417 st075190 100 µM -1.95652923154771 0.0289564779901219 no 3231 0.0252014212053144 4653 222757 SGTC_986 1493-0483 84 µM -1.9661748781919 0.0283682360525636 no 3232 0.024639206660692 4655 40079 SGTC_1630 st005209 31.3 µM -1.96709127070083 0.0283128706200662 no 3233 0.0245863447254891 4671 3367314 SGTC_2894 9048625 32.47 µM -1.97002272749827 0.0281363652445327 no 3234 0.0244178829376143 4678 4092861 SGTC_2288 7946289 167.31 µM -1.97663027012093 0.027741877678994 no 3235 0.0240417189847942 4656 1246052 SGTC_2180 6301957 200 µM -1.98124518546386 0.0274690975448067 no 3236 0.02378189209722 4693 845462 SGTC_2975 9084847 53.72 µM -1.98526880378074 0.0272330963897345 no 3237 0.0235572864584674 4649 27211724 SGTC_3162 9099653 49.47 µM -1.98632646069548 0.0271713421329819 no 3238 0.0234985431781722 4666 25237511 SGTC_2886 9058944 51.95 µM -1.99108797452868 0.0268947730144372 no 3239 0.0232356081426614 4669 4949929 SGTC_538 2922-0838 53.3 µM -1.99316808914421 0.0267746907639249 no 3240 0.0231215220651719 4699 777039 SGTC_1975 st070967 30.8 µM -1.99416418424413 0.0267173462433672 no 3241 0.0230670574083651 4662 261391 SGTC_1760 st045453 10.4495 µM -1.99568007099936 0.0266302745199008 no 3242 0.0229843788359603 4688 3323419 YIL048W NEO1 SGTC_882 0843-0131 351 µM -1.99606658560315 0.026608111291819 no 3243 0.0229633377717678 4703 5425421 SGTC_1634 st006576 41 µM -1.99914998465973 0.0264318565415565 no 3244 0.0227960641244146 4649 3915356 SGTC_2877 9040724 71.43 µM -2.00131513155719 0.0263086753482403 no 3245 0.0226792200441341 4645 6463895 SGTC_1751 st044839 27.194 µM -2.00418449933318 0.0261461687943437 no 3246 0.0225251501919063 4706 5291326 SGTC_2097 5376186 200 µM -2.01217598721716 0.0256979899862827 no 3247 0.0221006944113858 4691 742755 SGTC_2176 5809774 33.9695 µM -2.01501507939854 0.0255403239512234 no 3248 0.0219515345490461 4629 2870539 SGTC_1689 st020265 53.493 µM -2.01714263241033 0.0254227041405972 no 3249 0.0218403153694064 4676 5758320 YPR016C TIF6 SGTC_918 glabranin 770.725 nM -2.01910397133131 0.0253146755629461 no 3250 0.0217382070943429 4665 124049 Also referred to as licorice root. SGTC_188 3229-0966 278.469 µM -2.02681975312345 0.0248934233247028 no 3251 0.0213404247893539 4720 5722370 SGTC_3084 9116877 49.47 µM -2.02695674207046 0.0248859976860736 no 3252 0.0213334183913729 4656 27241325 SGTC_564 3555-0129 330 µM -2.02731873793923 0.0248663842356177 no 3253 0.0213149132135577 4656 563260 SGTC_910 3454-3003 490 µM -2.03210199500114 0.0246084356594703 no 3254 0.0210716657382193 4615 820824 SGTC_2563 tomatine 8.54 µM -2.03798106733053 0.0242944720836554 no 3255 0.0207759131555595 4618 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3327 9140648 26.9345 µM -2.04064209019516 0.0241534735942424 no 3256 0.020643207653274 4706 8029710 SGTC_133 0724-0033 378.92 µM -2.04793126323839 0.0237707614492008 no 3257 0.0202833675130448 4644 280309 SGTC_2497 7-hydroxyflavone 100 µM -2.06242257072484 0.0230250385022477 no 3258 0.0195837611357294 4692 5281894 SGTC_829 1635-0120 117 µM -2.07416826671645 0.0224351521913015 no 3259 0.0190318431309128 4690 285054 SGTC_2469 5655019 90.81 µM -2.11162924448684 0.0206382745425311 no 3260 0.0173591310847362 4737 2788239 SGTC_2764 methyldopa 94.69 µM -2.11316994036878 0.02056706060255 no 3261 0.0172931125682887 4679 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1117 retinoic acid 1.10837 µM -2.11351441992374 0.0205511665990239 no 3262 0.0172783810597126 4740 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1968 st069590 43.6 µM -2.11641163067476 0.0204179030027594 no 3263 0.0171549068722986 4684 6384066 SGTC_3107 9121808 49.47 µM -2.11787179596103 0.0203510175016579 no 3264 0.0170929634034042 4669 662681 SGTC_1955 wogonin 32.4 µM -2.12988615241127 0.0198076964739417 no 3265 0.0165905068284566 4677 5281703 A flavanone. SGTC_1103 duloxetine 36.1 µM -2.13275509071057 0.0196797919624721 no 3266 0.016472411024202 4736 60835 A selective serotonin reuptake inhibitor. SGTC_891 0929-0073 133 µM -2.13291749310582 0.0196725726723918 no 3267 0.0164657475345217 4723 5603632 SGTC_627 1391-0720 175 µM -2.13401689344669 0.0196237600262636 no 3268 0.0164206989898522 4716 997839 SGTC_1596 piperlongumine 63 µM -2.13442573232574 0.019605634103506 no 3269 0.016403973526245 4720 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3320 9137005 35.139 µM -2.15011209764361 0.0189208359345024 no 3270 0.0157731744588446 4724 4908713 SGTC_2745 rifampicin 24.3 µM -2.15993595857526 0.0185024149258371 no 3271 0.0153888137975949 4777 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1920 st075728 45.7 µM -2.16926372746381 0.0181124420611761 no 3272 0.0150313336892102 4699 3400306 SGTC_481 bay k-8644 50 µM -2.17148284310928 0.0180207044482273 no 3273 0.0149473463413315 4703 2303 A calcium channel antagonist. SGTC_1206 3978-0017 132 µM -2.1867025593063 0.0174021397166917 no 3274 0.0143821223321134 4692 3873677 SGTC_326 k292-0812 17.5 µM -2.1915497002186 0.0172089868067381 no 3275 0.0142060186577113 4733 3579357 SGTC_2742 clothiapine 36.27 µM -2.19439239921414 0.0170965629562732 no 3276 0.0141036059332401 4739 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2905 7799065 20.05 µM -2.20747245869709 0.0165873234976833 no 3277 0.0136405345285821 4665 1296806 SGTC_3313 9133968 57.047 µM -2.21529095098121 0.0162891724406882 no 3278 0.0133700502801201 4732 1494643 SGTC_2898 9056270 58.44 µM -2.2289453680206 0.0157794770826229 no 3279 0.0129087700002955 4747 19154699 SGTC_149 3970-0822 46.1 µM -2.23756745052998 0.0154647259935884 no 3280 0.0126246380772844 4721 3114250 YBL034C STU1 SGTC_1997 st073024 93.8 µM -2.24055197659068 0.0153570381501667 no 3281 0.012527555202255 4754 686268 SGTC_1974 st069448 26.9 µM -2.25153012778516 0.0149664464645776 no 3282 0.0121759904556573 4719 6323587 YNR016C ACC1 SGTC_1453 4237-0541 195 µM -2.2556723140283 0.0148213066122058 no 3283 0.0120455803483208 4729 739892 SGTC_3164 9100705 49.47 µM -2.25722707735106 0.0147671418792695 no 3284 0.011996944646172 4745 17174235 SGTC_3086 9117350 49.47 µM -2.26605341720653 0.0144628664098188 no 3285 0.0117240564385862 4738 2679265 SGTC_1924 st058459 75.1 µM -2.26659417389949 0.0144444013425809 no 3286 0.0117075141642396 4715 688683 SGTC_1730 st033808 45.1 µM -2.26717199432331 0.0144246931037704 no 3287 0.0116898604676346 4687 1045166 SGTC_2254 7938975 95.19 µM -2.27751745025008 0.0140757295897835 no 3288 0.0113776718880421 4733 2969277 SGTC_2985 9022375 71.43 µM -2.27818419103443 0.0140534913977551 no 3289 0.0113578028885015 4707 4939335 SGTC_3061 glucosamine 200 µM -2.27829251747594 0.0140498811841629 no 3290 0.0113545775892269 4690 91431 and experimental redox chemotherapeutic SGTC_1929 genistein trimethyl ether 50.5 µM -2.29007732606298 0.0136618706198571 no 3291 0.0110084172531481 4714 136420 SGTC_81 0411-0046 9.971 µM -2.29539855192548 0.0134897233561694 no 3292 0.0108551471352173 4754 12925265 SGTC_780 0109-0199 192 µM -2.29632143270805 0.013460058526651 no 3293 0.0108287547605683 4742 610414 SGTC_702 1488-0190 94 µM -2.30119593092536 0.013304306599951 no 3294 0.0106902793985688 4752 949357 SGTC_607 4491-0986 66.8 µM -2.30794860315878 0.0130911159221438 no 3295 0.0105009976605493 4729 698981 YDR232W HEM1 SGTC_1315 1237-0019 3.69 µM -2.32766359421603 0.0124854989754846 no 3296 0.00996498686074409 4741 825140 SGTC_716 1683-5115 658 µM -2.32931779397191 0.0124358055056495 no 3297 0.00992111820142496 4735 723597 SGTC_3215 9129942 49.47 µM -2.34075252241621 0.0120969585233812 no 3298 0.00962245949041342 4716 17682944 SGTC_1313 1220-0047 237 µM -2.34120969346395 0.0120835791476058 no 3299 0.00961068396998469 4756 3528706 SGTC_1938 st074717 56.4 µM -2.36190776741674 0.011491126629395 no 3300 0.00909058245130512 4689 17250979 SGTC_1913 st060213 96.1 µM -2.36231162458915 0.0114798222979896 no 3301 0.00908068436266597 4726 688959 SGTC_1270 0831-1170 17.3 µM -2.36818649340452 0.0113164683797371 no 3302 0.00893776143353473 4761 6764716 SGTC_2692 st077426 47.7 µM -2.37138883043834 0.0112282792334695 no 3303 0.00886068845061107 4731 25238571 SGTC_1215 3852-0577 11.2 µM -2.39529668650417 0.0105885577258143 no 3304 0.00830346074417467 4763 2884876 SGTC_2490 carminic acid 95.39 µM -2.40227032069115 0.0104080435729163 no 3305 0.00814683146662013 4727 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3195 9113082 49.47 µM -2.41973527580974 0.00996768449823795 no 3306 0.00776590476394132 4723 17018038 SGTC_67 0335-0847 266 µM -2.44584901879037 0.00933960634646148 no 3307 0.00722557512312528 4717 4552207 YOR254C SEC63 SGTC_1044 1222-0021 1.78 µM -2.47173537431477 0.00875144774146546 no 3308 0.00672295025663682 4713 4306703 SGTC_2219 9098279 200 µM -2.50149601961728 0.00811561024325073 no 3309 0.00618349163011491 4756 902349 SGTC_2519 cryptotanshinone 88.04 µM -2.51422965286825 0.00785619869913598 no 3310 0.00596463622563302 4757 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_697 0508-1955 564 µM -2.51809273770109 0.00777895500210523 no 3311 0.0058996124797703 4766 6243113 SGTC_1917 st066507 28.5 µM -2.52177363985211 0.00770597667335221 no 3312 0.00583824095264253 4683 3156428 SGTC_1060 3448-7350 82 µM -2.52719199514195 0.00759964770357951 no 3313 0.00574893136131047 4742 570178 SGTC_570 0987-0065 62.6 µM -2.53454201670447 0.0074574777932692 no 3314 0.00562972116877669 4728 3104428 SGTC_1758 st042942 75.2445 µM -2.53837984871111 0.00738417876855402 no 3315 0.0055683518095983 4752 669317 SGTC_1120 ficusin 1.78878 µM -2.54582018513267 0.00724388195603522 no 3316 0.00545106654071688 4743 6199 A DNA cross-linker. SGTC_549 1661-1316 519 µM -2.54904092079129 0.00718388352790241 no 3317 0.00540098123298875 4779 2857282 SGTC_1961 st076550 68.7 µM -2.56666077957021 0.00686334219984615 no 3318 0.00513415048323799 4771 1579337 SGTC_1927 st060202 13.8 µM -2.5699254956967 0.00680535745900781 no 3319 0.00508601944641889 4742 688887 SGTC_3354 9151612 71.43 µM -2.57969019355963 0.00663450106542025 no 3320 0.0049444493442445 4749 27261949 SGTC_623 k072-0108 16.9 µM -2.59742361919655 0.00633388868376986 no 3321 0.00469630035639475 4773 5382803 SGTC_2999 9069765 71.4286 µM -2.60321392559232 0.00623837808465491 no 3322 0.00461771533262916 4733 2097066 SGTC_1184 1269-1718 139 µM -2.64587268401057 0.00557317320042363 no 3323 0.00407402385004093 4784 5403821 SGTC_766 1391-0721 126 µM -2.65171888831719 0.00548709965471479 no 3324 0.00400415929993667 4780 1020919 YIL115C NUP159 SGTC_2946 9065502 71.43 µM -2.65645284923513 0.00541826929923911 no 3325 0.00394837464973038 4740 16489101 SGTC_1855 st056195 39.6 µM -2.66729235363732 0.00526354896913706 no 3326 0.00382325619323904 4738 4028379 SGTC_1781 st038725 66.3 µM -2.6750475886778 0.00515527713320724 no 3327 0.00373593216021843 4768 4270275 YIL048W NEO1 SGTC_2347 9049783 174.81 µM -2.6988659089387 0.00483503373283482 no 3328 0.00347881020207888 4760 6467988 YPL169C MEX67 SGTC_351 caspofungin 25 nM -2.69963345723392 0.00482501547765693 no 3329 0.00347079541197244 4773 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2605 digitonin 300 nM -2.74268334498558 0.00429190715469888 no 3330 0.00304697096743845 4773 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_101 0490-5701 117.494 µM -2.78692540168371 0.00379951236461183 no 3331 0.00266053633050842 4745 4661669 SGTC_1946 st076057 65.1 µM -2.82875295091649 0.00338120740823012 no 3332 0.0023364878136385 4788 953009 SGTC_180 1486-1293 102.781 µM -2.84433299028408 0.0032362988249186 no 3333 0.00222522550409294 4757 4140536 SGTC_2139 5578692 56.4705 µM -2.85179636479981 0.00316888209711275 no 3334 0.00217364701502936 4782 650991 YMR113W FOL3 SGTC_3149 9097855 49.47 µM -2.87057975060342 0.00300477045740784 no 3335 0.00204859915043663 4765 25236625 YMR079W SEC14 SGTC_1294 1000-1494 117 µM -2.87413605226952 0.00297457517041911 no 3336 0.00202567200138161 4792 712797 YDL207W GLE1 SGTC_2566 crystal violet carbinol 226 nM -2.87699504822759 0.00295049903087807 no 3337 0.00200740947714715 4725 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3314 9135860 59.4275 µM -3.01132250185477 0.00199925026558875 no 3338 0.00130056213500593 4787 25252478 SGTC_1115 galangin 695.678 nM -3.01287424142853 0.00199011373670785 no 3339 0.00129393066922572 4806 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2461 5755302 26.15 µM -3.09015978192532 0.00158029803445811 no 3340 0.00100024422302326 4794 2788904 SGTC_1314 1222-0010 41.1 µM -3.13422219479088 0.00138265563789939 no 3341 0.000861551627337836 4791 3526027 SGTC_2839 9003951 25.97 µM -3.17305803614476 0.00122746443709273 no 3342 0.00075421184161299 4800 2990634 SGTC_2705 st078069 42.8 µM -3.27010898017848 0.00090674967206449 yes 3343 0.00053753029017929 4800 1530061 SGTC_3345 9148410 3.559 µM -3.27990644247745 0.000879076014138422 yes 3344 0.000519207579842228 4782 4903596 SGTC_2954 9074818 52.69 µM -3.29649825788352 0.000833976123719584 yes 3345 0.000489491108881263 4787 16648742 SGTC_2041 5107442 45.335 µM -3.38053168219555 0.000636534126898775 yes 3346 0.000361728670146772 4805 793005 SGTC_2341 7987486 176.74 µM -3.42195992877118 0.000555983950561252 yes 3347 0.00031085737800392 4796 1258686 SGTC_692 k241-0027 77.8 µM -3.52050717428103 0.000400732846296457 yes 3348 0.000215361170342988 4807 3600480 SGTC_571 k831-0106 44.2 µM -3.55083324883463 0.000361745204784367 yes 3349 0.000192006817951788 4799 4783639 SGTC_2175 5807670 165.306 µM -3.76012040869886 0.000174881265611233 yes 3350 8.49157968129867e-05 4805 241186 SGTC_148 3253-0744 288.01 µM -3.88462538632582 0.000111576668073192 yes 3351 5.12438951806382e-05 4795 6893655 SGTC_585 0kpi-0023 191 µM -4.29103734032461 2.35482905505404e-05 yes 3352 8.89202022695164e-06 4794 64601 SGTC_587 k089-0003 57 µM -4.4994878199973 1.00563176938385e-05 yes 3353 3.40586911841115e-06 4793 9659696 SGTC_2971 9092186 9.93 µM -4.72819893361051 3.79298965123327e-06 yes 3354 1.13260096423424e-06 4803 25236400 SGTC_182 3448-4371 550.524 µM -5.03641436383076 9.51458897842322e-07 yes 3355 2.37166585973755e-07 4797 3491403 SGTC_143 4032-1194 15.74 µM -5.49032696448829 1.07415233831628e-07 yes 3356 2.00595180869319e-08 4809 1806963