SGTCid condition conc unit UME1|YPL139C.score UME1|YPL139C.strain.pval UME1|YPL139C.strain.significant UME1|YPL139C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_263 alizarin 107.927 µM 6.51904510584438 3.97591813649166e-11 yes 1 3.537818822269e-11 21 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_158 k038-0087 26.446 µM 5.67050269576217 7.81118918880768e-09 yes 2 7.11895646706666e-09 73 X158
SGTC_829 1635-0120 117 µM 5.33713845149798 5.13569741898312e-08 yes 3 4.72124688657848e-08 14 285054
SGTC_577 r071-0003 38.6 µM 5.17764053677982 1.21731210646709e-07 yes 4 1.12354830581466e-07 24 4568517 YMR134W ERG29
SGTC_3254 9136651 49.47 µM 5.15532088871589 1.37088057810325e-07 yes 5 1.26598479888234e-07 7 16454030
SGTC_903 1134-0042 114 µM 4.90889606426919 4.92955192650817e-07 yes 6 4.57952502130109e-07 11 701009
SGTC_2046 4110841 106 µM 4.71656372331208 1.28519995891187e-06 yes 7 1.19930632624426e-06 15 44119630 YMR134W ERG29
SGTC_142 0335-0849 62.6745 µM 4.6410995309583 1.85371242870729e-06 yes 8 1.73280067938329e-06 97 3889043 YPR107C YTH1
SGTC_890 0929-0006 47.2 µM 4.57942968659216 2.49043469312907e-06 yes 9 2.33122745466587e-06 10 1378169
SGTC_2481 5478948 45.16 µM 4.55843682023393 2.75147342721664e-06 yes 10 2.57678813655294e-06 22 77792
SGTC_3143 9086658 49.47 µM 4.47959107220161 3.98582951419715e-06 yes 11 3.73930882142428e-06 29 25236626
SGTC_2797 7859098 81.82 µM 4.44822110840907 4.61145255115426e-06 yes 12 4.32921882281466e-06 21 972681
SGTC_2399 5884133 200 µM 4.43011962054781 5.01405215345652e-06 yes 13 4.70904160148902e-06 54 722445
SGTC_1940 st075990 51.1 µM 4.42584083824414 5.11400958332678e-06 yes 14 4.80336697478572e-06 12 1084979
SGTC_3209 9113616 49.47 µM 4.41364303533269 5.40951751501553e-06 yes 15 5.08227536423264e-06 17 16649353
SGTC_3083 9117465 49.47 µM 4.35130901523575 7.19232566211876e-06 yes 16 6.76635840530449e-06 9 16420915
SGTC_1658 st012944 20 µM 4.2923444388136 9.38446366567578e-06 yes 17 8.83982047694417e-06 68 24207260
SGTC_572 0960-0087 17.7 µM 4.26241624583683 1.07275826143874e-05 yes 18 1.01114151736357e-05 21 6796365
SGTC_3258 9138477 49.47 µM 4.25643859969133 1.1016924531373e-05 yes 19 1.0385452255319e-05 5 4970355
SGTC_737 1950-0117 57.9 µM 4.22302547348821 1.27760374924467e-05 yes 20 1.20522282016392e-05 18 5393513
SGTC_255 tunicamycin 200.472 nM 4.12331938385685 1.97528805044393e-05 yes 21 1.86725656322888e-05 65 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2817 7995342 71.43 µM 4.11455488967036 2.05148431238049e-05 yes 22 1.93963621970828e-05 20 18879975
SGTC_2064 5220758 200 µM 3.99659503878348 3.3901186006729e-05 yes 23 3.21300449995871e-05 36 788518
SGTC_36 0335-0881 14.2 µM 3.96185344017833 3.92075140537986e-05 yes 24 3.71850943479496e-05 120 23828853
SGTC_200 k038-0079 37.545 µM 3.87138243155973 5.69504870247093e-05 yes 25 5.41099253788111e-05 56 3436683
SGTC_2543 pimpinellin 60.67 µM 3.85388555976026 6.11595006730724e-05 yes 26 5.81289760200036e-05 14 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1641 st009299 47.1 µM 3.83746135090407 6.53758654616102e-05 yes 27 6.21563959700071e-05 7 4046054
SGTC_3236 9132701 49.47 µM 3.81929284098097 7.03585303370153e-05 yes 28 6.69174012682107e-05 30 24282524
SGTC_2923 7992654 58.14 µM 3.79161054702609 7.86428294007765e-05 yes 29 7.48367490565741e-05 31 2985126
SGTC_2126 5251174 33.877 µM 3.78369887984509 8.11741351843972e-05 yes 30 7.72573745333804e-05 41 790722
SGTC_2007 4011539 71.82 µM 3.7732894284576 8.46215070612403e-05 yes 31 8.05546016015061e-05 70 45595301
SGTC_2451 5856223 45.7 µM 3.74589720511821 9.43628047816373e-05 yes 32 8.98750946807849e-05 26 2179896
SGTC_748 act1.228 77.9 µM 3.65538750538691 0.000134576293849 yes 33 0.000128396898206045 89 4421505 YNR035C ARC35
SGTC_1671 st016596 74.5 µM 3.570814645816 0.000186205577659479 yes 34 0.000177936335951329 21 2829167
SGTC_3247 9135149 49.47 µM 3.56520524200422 0.000190214175629482 yes 35 0.000181785781354858 28 8934436 YOR116C RPO31
SGTC_581 0958-0271 211 µM 3.53708042810971 0.000211557469767296 yes 36 0.000202288221195335 69 4591145
SGTC_165 k038-0023 64.381 µM 3.50076450950287 0.00024243051511166 yes 37 0.000231962796698222 106 46368543
SGTC_2751 anetholtrithion 17.25 µM 3.47286658264497 0.00026894770610153 yes 38 0.000257465631044217 40 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_137 0438-0332 85.389 µM 3.44043220616032 0.000303165729007507 yes 39 0.000290392957988423 153 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_513 4245-1575 41.7 µM 3.43788198499193 0.00030602119476753 yes 40 0.000293141578088702 150 719745
SGTC_2051 5263410 176 µM 3.36676503736242 0.000396481409014187 yes 41 0.000380277296230011 33 227584
SGTC_2350 9023895 38.85 µM 3.36364403108833 0.000400969718526832 yes 42 0.000384603435977567 49 2997209
SGTC_16 erodoxin 22.806 µM 3.36312918730455 0.000401714628686112 yes 43 0.000385321454697036 87 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3233 9132340 49.47 µM 3.34019067672796 0.000436236801300933 yes 44 0.000418604433655667 42 17682950
SGTC_34 0469-0683 81.75 µM 3.32183680259869 0.000465818663569126 yes 45 0.000447134909723142 50 3690923
SGTC_21 0849-0113 22.993 µM 3.2800324591881 0.000540266700141326 yes 46 0.000518975720367577 56 1560156
SGTC_397 arbidol 50 µM 3.27981063540171 0.000540689561241978 yes 47 0.000519383920428355 43 131410 A RNA synthesis inhibitor.
SGTC_67 0335-0847 266 µM 3.27919348635268 0.000541867639223028 yes 48 0.000520521161598529 157 4552207 YOR254C SEC63
SGTC_310 1273-0058 1.06 µM 3.24155703361509 0.00061836615870301 yes 49 0.000594393220548429 318 2734232
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 3.22678503866174 0.000651027405496865 yes 50 0.000625947359383511 101 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2071 5230951 39.92 µM 3.20634459227435 0.000698851423407595 yes 51 0.000672164486342637 44 1799272
SGTC_440 fluspirilene 35.1 µM 3.14482872556647 0.000863008423117677 yes 52 0.00083092045712874 47 3396 An atypical antipsychotic.
SGTC_86 0417-1630 471.922 µM 3.1353608197326 0.000891214101677493 yes 53 0.0008582142686954 209 3634867
SGTC_696 1560-0013 611 µM 3.13425247403305 0.000894570783502972 yes 54 0.000861462723322095 52 1650269
SGTC_3141 9094609 49.47 µM 3.13125334651946 0.000903712147414302 yes 55 0.00087030965829509 76 25236309 YDL196W YDL196W
SGTC_2758 dehydroepiandrosterone 69.35 µM 3.0814811346379 0.00106850470577811 no 56 0.00102986764153952 85 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1134 3477-0009 42.5 µM 3.05215196822382 0.00117808295069318 no 57 0.00113603519697294 91 3973534
SGTC_2475 5812728 15.03 µM 3.04177805352077 0.00121924190455615 no 58 0.0011759261858785 59 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3196 9111891 49.47 µM 2.99879683154909 0.00140417179665466 no 59 0.00135523992552844 44 18891510
SGTC_1365 1672-3266 55.4 µM 2.98536010888336 0.00146703624982492 no 60 0.00141622329768189 67 6415873
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.96590654275063 0.00156260847588494 no 61 0.00150896091146457 73 688664
SGTC_1078 idebenone 36.1 µM 2.95834982677228 0.00160123959062223 no 62 0.00154645451151158 100 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2504 purpurogallin 52.29 µM 2.95665017075977 0.00161004752241529 no 63 0.00155500373485588 55 5281571 An antioxidant.
SGTC_2303 7774051 200 µM 2.9489473994241 0.00165052075297172 no 64 0.00159429120624109 58 2953184
SGTC_2251 lansoprazole 556 µM 2.92465111413849 0.00178432860742262 no 65 0.00172421301603216 47 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2164 5685496 200 µM 2.89070111655417 0.00198784989533055 no 66 0.00192191747656659 59 759046
SGTC_3103 9120822 49.47 µM 2.8893227167031 0.00199654163149177 no 67 0.00193036316601597 60 17141819
SGTC_2063 5246145 200 µM 2.84317208141949 0.0023082311682825 no 68 0.00223334733900836 81 711240
SGTC_380 3970-0968 6 µM 2.83844774339808 0.00234250488765312 no 69 0.00226667708567348 64 2891601
SGTC_2292 7671323 168.05 µM 2.83618159883294 0.00235910806284905 no 70 0.0022828238703884 98 937504
SGTC_1131 3454-3128 32.3 µM 2.83423499758316 0.00237345503952054 no 71 0.00229677694258223 109 710982
SGTC_704 1310-0270 142 µM 2.82089761917058 0.00247389809928501 no 72 0.00239447419912396 99 5718033
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.80434657396506 0.00260388111731137 no 73 0.00252093385725411 101 4174840
SGTC_576 1073-0113 22.7 µM 2.78890301585143 0.00273069867600137 no 74 0.00264434499613296 169 5439563
SGTC_722 3534-0461 190 µM 2.78233519672966 0.00278630125159243 no 75 0.00269846337372974 101 658262
SGTC_1614 st002383 48.6 µM 2.78175327685849 0.00279127666750652 no 76 0.00270330625212635 73 1947235
SGTC_1937 st074714 47.2 µM 2.77924230401548 0.00281283754021325 no 77 0.00272429328569057 103 17250970
SGTC_676 falcarinol 140 µM 2.77585302212369 0.00284217841697071 no 78 0.00275285458175949 113 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.7565181680081 0.00301490127976061 no 79 0.00292101835747079 143 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1347 1493-0251 600 nM 2.74133294311057 0.00315712310674874 no 80 0.0030595234083726 79 3986378
SGTC_2636 apigenin dimethyl ether 100 µM 2.73245159132316 0.00324307578229125 no 81 0.00314324544384094 128 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_353 1988-1175 58.3 µM 2.72489656399603 0.00331784314449952 no 82 0.00321608172342191 96 2788357
SGTC_400 oxethazaine 37.5 µM 2.72098860008772 0.00335712284513732 no 83 0.0032543503026494 80 4621 A local anesthetic.
SGTC_2604 4'-hydroxychalcone 11.32 µM 2.72048039286068 0.00336226153067751 no 84 0.00325935688104683 109 5282362
SGTC_3146 9095609 49.47 µM 2.68829663342591 0.00370244377511396 no 85 0.00359087834273108 92 17173999
SGTC_413 propylparaben 100 µM 2.68485769022607 0.00374056054107021 no 86 0.00362803472676714 94 7175 A pharmaceutical preservative.
SGTC_157 1348-1695 65.819 µM 2.68403159893558 0.00374976908178669 no 87 0.00363701154414245 160 5380510
SGTC_2950 9072895 21.46 µM 2.68230617393133 0.00376906820584334 no 88 0.00365582539370787 134 17332245
SGTC_1484 3473-2379 286 µM 2.66581570794399 0.00395805819900845 no 89 0.00384008909136702 78 671917
SGTC_762 1165-0429 115 µM 2.66308637774992 0.00399014374147227 no 90 0.00387137679571339 95 5967793
SGTC_2440 5628896 157.78 µM 2.66183801763895 0.00400489672734936 no 91 0.00388576337017793 76 5522048
SGTC_1742 st038235 28.8875 µM 2.64374939956629 0.0042242155690851 no 92 0.00409966681605458 218 564103 YBR002C RER2
SGTC_2498 4'-Methoxychalcone 54.63 µM 2.63035528210024 0.00439347249292874 no 93 0.0042647838209843 100 641818 YHR062C RPP1
SGTC_3245 9134821 49.47 µM 2.61983713619845 0.00453060720064834 no 94 0.00439858845680962 106 17014901
SGTC_2826 7992541 19.48 µM 2.61098269293421 0.00464899997215404 no 95 0.00451412313288048 100 2985066
SGTC_603 3794-0023 45.9 µM 2.6087485848316 0.00467930502510029 no 96 0.0045436990588046 78 3802260
SGTC_1769 st044406 64.4 µM 2.59707432428934 0.00484054774872574 no 97 0.00470107885767255 87 670903
SGTC_1077 5-fluorocytosine 377 nM 2.58649878192632 0.00499087141907724 no 98 0.00484782565453885 89 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2011 4012611 177 µM 2.58411981937748 0.00502525420611277 no 99 0.00488139356231607 120 2049887
SGTC_2395 5646831 180.19 µM 2.58305724287466 0.00504067950064226 no 100 0.00489645366115775 118 6808628
SGTC_1952 st077036 64.1 µM 2.57674679205652 0.00513315934775821 no 101 0.00498674901795904 117 2937007
SGTC_3214 9129694 49.47 µM 2.57596198490169 0.00514476567701523 no 102 0.00499808178954667 109 17158655
SGTC_2516 gossypol 71.55 µM 2.56472331202372 0.00531355280146354 no 103 0.00516290547888935 95 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_40 0327-0103 19.753 µM 2.54816188930891 0.00557125679094655 no 104 0.00541461020464786 120 409036
SGTC_2990 9074105 71.4286 µM 2.53973716299141 0.00570656223952389 no 105 0.00554679016400823 77 6502001
SGTC_2268 7933382 153.85 µM 2.53335955817882 0.00581092166905066 no 106 0.0056487500812627 143 935025 YOR257W CDC31
SGTC_3077 9117319 49.47 µM 2.51430995328532 0.00613279120509747 no 107 0.00596327816189704 83 17154678
SGTC_2256 7954252 200 µM 2.51128340778651 0.00618535769697939 no 108 0.00601465395266932 67 2972920
SGTC_1611 st001856 99.4 µM 2.50424158985494 0.00630921071955537 no 109 0.00613571048716838 100 647478
SGTC_1385 3091-4834 14.1 µM 2.47028223414545 0.00693783240618116 no 110 0.00675032447920958 102 4072814
SGTC_635 k038-0028 24.7 µM 2.46748169403823 0.00699206124822945 no 111 0.00680335892529671 163 4035102
SGTC_1224 0823-0416 294 µM 2.4449795789062 0.00744153815936402 no 112 0.00724301719602165 112 3598164
SGTC_974 1326-0144 138 µM 2.4438167125229 0.00746544300590879 no 113 0.00726640381115742 158 5411856
SGTC_2967 9089538 49.85 µM 2.44340795414223 0.00747386183837882 no 114 0.00727464022560017 152 728216
SGTC_1670 st016595 4.04 µM 2.43669368796752 0.00761335160346334 no 115 0.00741111456249229 109 597879
SGTC_2155 5570423 76 µM 2.42870664229315 0.00778226474186212 no 116 0.00757639368724263 103 797402
SGTC_1443 4112-3303 14 µM 2.41164694896367 0.00815413128660841 no 117 0.00794032543719495 108 704433
SGTC_2325 6158266 200 µM 2.40523248836713 0.00829794093537081 no 118 0.00808109003082383 129 3623240
SGTC_821 1114-0266 29.2 µM 2.38486068210239 0.00876954333654943 no 119 0.00854279517378154 131 3123235
SGTC_64 000l-0018 272.079 µM 2.38165326348409 0.00884589667639021 no 120 0.00861755856160076 310 6811119
SGTC_1667 st014849 34.6 µM 2.37579151044843 0.00898694339870421 no 121 0.00875567706397273 98 5348460
SGTC_416 estradiol valerate 100 µM 2.36305248779164 0.00930028215385177 no 122 0.00906255116617874 124 13791 A steroid.
SGTC_919 tnp00227 403.569 nM 2.35947561048629 0.00938996307109816 no 123 0.00915039190500409 162 1269246 A methoxyflavone. YNL221C POP1
SGTC_525 k781-2675 26.7 µM 2.35814873767594 0.00942342280199709 no 124 0.00918316620093536 176 3651118 YDL195W SEC31
SGTC_3132 9126706 49.47 µM 2.34648595228843 0.00972203728918057 no 125 0.0094756902929764 132 850858
SGTC_123 0083-0120 66.675 µM 2.34328003510272 0.00980555686595221 no 126 0.00955751496138984 169 16001701
SGTC_2773 thioridazine 9.09 µM 2.33762617977715 0.0099543772535193 no 127 0.0097033243201626 121 5452 An antipsychotic.
SGTC_964 1287-0107 19.4 µM 2.33633914833628 0.00998852863417694 no 128 0.00973678635224965 180 51516812 YPR165W RHO1
SGTC_2626 ethyl orsellinate 100 µM 2.31492117557328 0.0105720524934534 no 129 0.0103086231312998 146 75653 A natural product.
SGTC_573 3702-0553 84.7 µM 2.30309316840595 0.0109068601556299 no 130 0.0106368008026555 116 1222756
SGTC_1903 st060211 78.3 µM 2.2998030936172 0.0110016150714828 no 131 0.0107296890594118 165 688960
SGTC_2367 9070478 135.38 µM 2.2990258129577 0.0110241052338862 no 132 0.0107517367895501 173 572802
SGTC_1884 5633444 25 µM 2.28737481552759 0.0113660436834985 no 133 0.0110869774909368 195 5724239
SGTC_1771 st048882 4.1505 µM 2.2789748757204 0.0116182515511092 no 134 0.0113342794221226 140 4580403
SGTC_1645 Cervolide 78 µM 2.27488139511524 0.0117429093135814 no 135 0.0114565228555011 106 23173 A fragrance.
SGTC_1931 st074438 57.1 µM 2.27184566969602 0.011836103608766 no 136 0.0115479166776562 135 2787313
SGTC_2982 9019404 25.97 µM 2.26150741040019 0.0121583098654506 no 137 0.0118639271686265 159 22333232
SGTC_837 0091-0265 12.5 µM 2.25412984632976 0.0123928653552092 no 138 0.0120940002657207 162 759367
SGTC_3131 9127911 49.47 µM 2.24994815920236 0.012527546589923 no 139 0.0122261181598773 162 45595681
SGTC_363 0455-0021 3.06 µM 2.24058545075497 0.0128336974566185 no 140 0.0125264700054988 224 4597466
SGTC_2881 9058953 51.95 µM 2.23742205747252 0.0129385896358943 no 141 0.0126293841187708 192 17122249
SGTC_767 0929-0023 86 µM 2.23454130285436 0.0130347541470592 no 142 0.0127237390345302 279 1204563
SGTC_431 k089-0097 107 µM 2.22112789200743 0.0134906953162813 no 143 0.0131711501867925 238 5499420
SGTC_1370 2001-0092 44.6 µM 2.21666302416844 0.0136454863446934 no 144 0.0133230636582965 201 790957
SGTC_1364 1653-0028 37.6 µM 2.19983164127594 0.0142428641592633 no 145 0.0139094210768618 178 5718652
SGTC_848 0368-0089 85.6 µM 2.19561735549722 0.0143959168322962 no 146 0.0140596714751392 178 762535
SGTC_1939 st074455 53.6 µM 2.19533901712236 0.0144060750753097 no 147 0.0140696440298918 191 1644229
SGTC_1966 st070145 16.1 µM 2.18884400388777 0.0146448755968744 no 148 0.0143040900867944 166 3748532
SGTC_3151 9099821 49.47 µM 2.18630905887167 0.0147389971070509 no 149 0.014396500915533 164 17174189
SGTC_1328 1441-0025 69.2 µM 2.18444056973822 0.0148087060627295 no 150 0.0144649449167066 138 4562601
SGTC_207 4185-0010 4.486 µM 2.18268089043593 0.0148746146424183 no 151 0.0145296590796153 258 3761753
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.1820504657547 0.0148982884143509 no 152 0.0145529042001867 146 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1693 xanthone 101.9 µM 2.16300006893274 0.0156291088818718 no 153 0.0152705871571941 173 7020 An insecticide.
SGTC_1018 4259-0013 28.1 µM 2.1513556328877 0.0160907987401452 no 154 0.015724070128451 164 6801262
SGTC_648 0375-0473 33.3 µM 2.13154449731551 0.0169031570553405 no 155 0.0165221553418423 196 1713139
SGTC_1474 0330-0125 5.35 µM 2.12701720128106 0.0170936456071617 no 156 0.0167093270003134 159 X1474
SGTC_3073 9114972 49.47 µM 2.12099321341677 0.0173499507626282 no 157 0.0169611867718748 160 41905075
SGTC_2524 avocatin b 10.57 µM 2.1045762528497 0.0180651699115756 no 158 0.0176641052769545 155 6710748
SGTC_3250 9135583 49.47 µM 2.10099331338778 0.0182245620618885 no 159 0.0178207766108203 139 7699353
SGTC_1953 st076800 12.1 µM 2.10034940742088 0.0182533338061004 no 160 0.0178490580051669 242 297591
SGTC_3074 9116018 49.47 µM 2.09437317973416 0.0185222219297808 no 161 0.0181133750085591 157 17027303
SGTC_2320 7373003 200 µM 2.09016570453892 0.0187135454797434 no 162 0.0183014585586713 184 5415828
SGTC_2825 7998094 58.44 µM 2.08287933143327 0.0190488524851532 no 163 0.0186311120119581 205 2987815
SGTC_1947 st076332 61.6 µM 2.07383382980861 0.0194722073385769 no 164 0.0190473730674942 153 24208416
SGTC_2965 9082772 38.63 µM 2.07265507772803 0.0195279604814961 no 165 0.0191021956377002 229 16459634
SGTC_2389 9091542 195.52 µM 2.0700251819783 0.0196528393221278 no 166 0.0192249931716624 230 3626624 YOL127W RPL25
SGTC_3331 9141060 1.957 µM 2.06650047098652 0.0198212707019711 no 167 0.0193906239903018 188 4906567 YPR165W RHO1
SGTC_663 1486-0733 13.9 µM 2.06338718954162 0.0199710589934817 no 168 0.0195379280449857 272 722445 YPR165W RHO1
SGTC_1453 4237-0541 195 µM 2.06292436904377 0.0199934083113529 no 169 0.0195599072086048 196 739892
SGTC_1744 st037937 38.9 µM 2.05952539973568 0.0201581934455909 no 170 0.0197219671926468 207 1016152
SGTC_921 1561-0023 372 µM 2.03184982693777 0.0215432873991866 no 171 0.021084430574271 202 24050882
SGTC_2378 9074213 121.43 µM 2.02863387280047 0.0217093355304342 no 172 0.0212477978999262 231 657714
SGTC_2239 6685329 187.64 µM 2.02513177707997 0.0218913864310872 no 173 0.0214269173510064 228 805680
SGTC_1822 st052468 42 µM 2.02090646168383 0.0221127471716175 no 174 0.021644724443807 172 2873678
SGTC_119 0121-0043 24.815 µM 2.01585946101042 0.0223796284291674 no 175 0.0219073368644999 408 1092378
SGTC_1247 0448-0043 5.84 µM 2.00083413866748 0.0231902893182875 no 176 0.0227051335458799 296 3089013 YGL099W LSG1
SGTC_1731 st035964 63 µM 1.99928034998451 0.0232755138874387 no 177 0.0227890145198424 236 6739575
SGTC_1253 0550-0034 176 µM 1.99472126440349 0.0235271005104374 no 178 0.0230366444202665 215 5969915
SGTC_2659 sanguinarine 24.21 µM 1.99152180621226 0.0237050207918717 no 179 0.0232117751577968 209 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_741 4582-0002 126 µM 1.98488247587791 0.0240778423016368 no 180 0.0235787742585316 223 2912688
SGTC_3142 9086498 49.47 µM 1.9803113417239 0.0243373807503485 no 181 0.0238342775760063 215 25236367
SGTC_2714 st079313 56.9 µM 1.97677324235438 0.024539874975347 no 182 0.0240336337705437 199 2939799
SGTC_2882 9058044 58.44 µM 1.97632797441779 0.0245654586549129 no 183 0.0240588216156906 192 18076804
SGTC_2041 5107442 45.335 µM 1.9695637060876 0.0249568728129008 no 184 0.0244441973210643 257 793005
SGTC_1390 3413-2614 145 µM 1.9664816529092 0.0251369422920129 no 185 0.0246214998081762 256 3421432
SGTC_2113 5491891 107.031 µM 1.96510434525074 0.0252177630638677 no 186 0.0247010809008949 264 789979
SGTC_1227 3909-8010 46.6 µM 1.96086725252147 0.0254677632699372 no 187 0.0249472551497471 222 15982272
SGTC_643 k048-0106 28.4 µM 1.96000479475932 0.0255189040968779 no 188 0.0249976149392744 196 6763920
SGTC_359 0081-0058 15.9 µM 1.95715218671591 0.0256886670883369 no 189 0.025164789164588 253 3494159
SGTC_2706 st078239 82.5 µM 1.95533244310999 0.0257974558676524 no 190 0.0252719221325072 211 15434492
SGTC_775 4577-0580 57.3 µM 1.95143233974013 0.0260319127621361 no 191 0.0255028187817737 207 2006902
SGTC_343 4130-2827 29.8 µM 1.94190590674501 0.0266121021791329 no 192 0.0260742461078051 249 1118244
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.94002180733026 0.0267281198954623 no 193 0.0261885198423751 252 1377
SGTC_274 sirtinol 40.1 µM 1.9362028224783 0.0269645786804791 no 194 0.0264214324689274 231 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1956 st077085 54 µM 1.91625599950191 0.028228170362584 no 195 0.0276662592736517 282 24208685
SGTC_1148 3909-7663 27.7 µM 1.91556769377912 0.0282726383681164 no 196 0.0277100724902738 234 4084526
SGTC_2864 9034755 47.6 µM 1.91199489205444 0.0285043970897997 no 197 0.0279384246113246 240 4930451
SGTC_2611 pyromycin 23.93 µM 1.91115404596083 0.0285591698181748 no 198 0.027992393713933 272 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1334 1486-0610 236 µM 1.90610883281034 0.0288896566151033 no 199 0.0283180434797399 256 3742339
SGTC_1448 4255-0083 152 µM 1.90402084289261 0.0290273574187073 no 200 0.0284537348603066 226 5399660
SGTC_3112 9123419 49.47 µM 1.89863243089542 0.0293852393516228 no 201 0.0288064106318577 258 17015854
SGTC_2997 9067075 71.4286 µM 1.89606061648546 0.0295573387390088 no 202 0.0289760147819121 291 27209819
SGTC_2096 5468907 200 µM 1.89287865624438 0.0297714246043888 no 203 0.0291870041346697 222 759785
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.89132419286219 0.0298764774867878 no 204 0.0292905405613487 239 4213774
SGTC_355 1311-2252 105 µM 1.89058350356763 0.0299266423968934 no 205 0.0293399820305428 280 5338538
SGTC_2796 7949634 45.45 µM 1.88957703386045 0.0299949198446331 no 206 0.0294072755549161 258 2971588
SGTC_3072 9116419 49.47 µM 1.88734403898239 0.0301468642873134 no 207 0.0295570333604272 225 17170162
SGTC_167 3672-0051 66.205 µM 1.88360003204233 0.0304030572978054 no 208 0.0298095487642212 257 3237971
SGTC_1084 voriconazole 435 nM 1.88103243820257 0.0305797919710948 no 209 0.0299837531866323 229 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_813 k007-0158 173 µM 1.87945246144763 0.0306889684909243 no 210 0.0300913693990376 313 6523916
SGTC_50 0929-0078 56.389 µM 1.87916243869113 0.0307090441055228 no 211 0.0301111583276501 282 1377751
SGTC_861 0443-0273 110 µM 1.87228957867011 0.0311879802601285 no 212 0.0305832758761054 229 6149169
SGTC_869 0564-0080 44.1 µM 1.87181809560724 0.0312210608379794 no 213 0.030615886948837 293 6843321
SGTC_58 0957-0393 9 µM 1.87023311237061 0.0313324805556572 no 214 0.030725726693097 697 6997992
SGTC_1831 st055328 12 µM 1.87019696588297 0.0313350253786029 no 215 0.0307282354543427 266 1103068
SGTC_2045 5106652 78.05 µM 1.8654827420262 0.0316683888498054 no 216 0.0310568845100441 222 673349
SGTC_2833 9001315 45.46 µM 1.85513635517502 0.0324103079388277 no 217 0.031788378698239 311 2989378
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.8456230109026 0.0331050905635217 no 218 0.0324734814802763 299 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_724 3910-0327 137 µM 1.84518998578154 0.0331370051961117 no 219 0.0325049533668044 277 2885483
SGTC_2036 5160441 105 µM 1.84453794635078 0.0331851093431646 no 220 0.0325523904856122 351 134534 YIL048W NEO1
SGTC_435 c-PAF 6.7 µM 1.8414608839438 0.0334128962111418 no 221 0.0327770238647212 304 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1372 2752-0194 270 µM 1.84070533622637 0.0334690238582916 no 222 0.0328323757629899 248 823334
SGTC_3212 9128307 49.47 µM 1.83917508668858 0.0335829398794848 no 223 0.0329447188882474 267 27243542
SGTC_2291 7917025 104.35 µM 1.83783768091395 0.033682761237754 no 224 0.0330431636710151 318 2964612
SGTC_2434 5670830 169.91 µM 1.83459965501826 0.0339254526699173 no 225 0.0332825149205253 300 1549830
SGTC_1356 1502-0781 85.8 µM 1.82828012838144 0.034403246735293 no 226 0.0337537602985506 266 567702
SGTC_444 curcumin 90.4 µM 1.82724084947495 0.0344823493802547 no 227 0.0338317822145986 278 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1026 k007-1105 30.6 µM 1.82529964153708 0.0346305007638925 no 228 0.0339779121267518 379 7066794
SGTC_507 nimesulide 162 µM 1.82246409816947 0.0348478462876974 no 229 0.0341922982214945 286 4495 A COX2 inhibitor.
SGTC_1396 3511-0007 98.6 µM 1.82127623137666 0.0349392289802493 no 230 0.0342824388077317 245 X1396
SGTC_3124 9127567 49.47 µM 1.82089796483112 0.0349683703155335 no 231 0.0343111843143994 242 17592030
SGTC_1608 st001473 40.5 µM 1.82038879207205 0.0350076280515871 no 232 0.0343499090168956 289 7292267
SGTC_1495 4469-0029 237 µM 1.82034676947731 0.0350108696514231 no 233 0.03435310661355 426 793680
SGTC_596 1155-0152 116 µM 1.81170132782193 0.0356830317895364 no 234 0.0350161791797064 350 280313
SGTC_1425 4048-4433 7.33 µM 1.80648898593263 0.0360933643696626 no 235 0.0354209965099876 304 23734946
SGTC_1488 4013-0813 75.9 µM 1.80434076508569 0.0362636000351835 no 236 0.0355889514502 219 2910057
SGTC_3278 9139605 49.47 µM 1.79298055659385 0.0371748000833058 no 237 0.0364880165493173 288 7958859
SGTC_496 calpeptin 138 µM 1.79035313195513 0.0373881876825866 no 238 0.0366985798834607 261 73364 A calpain inhibitor.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.78919558759258 0.0374825151825612 no 239 0.036791661022145 262 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_409 arachidonic acid 100 µM 1.78891065827376 0.0375057636610458 no 240 0.0368146025125955 281 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_830 4076-0286 57.8 µM 1.77461665761799 0.0386872633758701 no 241 0.037980602443222 481 6866659
SGTC_3022 9087993 49.47 µM 1.76859671207837 0.0391938464714721 no 242 0.0384805999264287 237 17173644
SGTC_2536 dehydroabietamide 32.04 µM 1.76692181419259 0.0393357464733092 no 243 0.038620661591113 324 3983547
SGTC_2804 7954240 19.48 µM 1.76604063228864 0.0394105692510258 no 244 0.0386945161440628 328 828705
SGTC_1431 4049-0260 9.09 µM 1.7579266133689 0.0401050011599153 no 245 0.039379998439919 290 3854841
SGTC_688 0527-0193 473 µM 1.7552621116266 0.0403351970193987 no 246 0.0396072420381834 261 4007154
SGTC_1510 1123-0200 71.5 µM 1.74840437250461 0.0409325992030371 no 247 0.0401970156527962 378 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.74179135876649 0.0415154605284071 no 248 0.0407724796566309 306 4330530
SGTC_693 4161-2696 114 µM 1.73956667119236 0.041713046295108 no 249 0.0409675678904665 237 805759
SGTC_1716 st033144 30.6155 µM 1.73566979722093 0.0420609824727989 no 250 0.0413111184002974 309 674617
SGTC_1302 1159-0335 255 µM 1.73361772870822 0.042245145434147 no 251 0.041492966354433 291 649284
SGTC_1025 k007-0731 70 µM 1.72937127840569 0.0426283152560771 no 252 0.0418713335156305 303 6256118
SGTC_1868 st057644 42.7 µM 1.72761584696967 0.0427875317466949 no 253 0.0420285598931845 349 688665
SGTC_1849 st056239 19.2 µM 1.72043923457393 0.043443451820901 no 254 0.042676315165027 342 5393181
SGTC_3100 9120536 49.47 µM 1.71520084235686 0.0439273306124365 no 255 0.0431542052491622 207 16421196
SGTC_390 dec-rvkr-cmk 16.7 µM 1.71429685241867 0.0440112717620052 no 256 0.0432371104633982 334 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.71047758836359 0.0443673431338604 no 257 0.0435887971457331 332 2333 A French combination drug.
SGTC_1770 st043884 66.3 µM 1.70920363301517 0.0444866294818373 no 258 0.043706618075452 312 670149
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.7067323024484 0.044718768372638 no 259 0.0439359101534998 269 6857784
SGTC_2798 7813637 45.45 µM 1.70395390415261 0.0449809147896601 no 260 0.0441948496470123 338 956368
SGTC_1898 st060199 18.6 µM 1.7022723953728 0.0451401677971684 no 261 0.0443521585241385 287 688866
SGTC_2448 5185112 27.17 µM 1.69758629302129 0.0455863760659277 no 262 0.044792935828471 296 5718189
SGTC_464 bw-b 70c 158 µM 1.69454865970195 0.0458775075857959 no 263 0.0450805367194848 372 5353454
SGTC_19 0279-0214 38.434 µM 1.69352850981757 0.0459756148090098 no 264 0.0451774564412815 415 3566274 YBR002C RER2
SGTC_2476 5806916 10.51 µM 1.6889001084104 0.0464228445213396 no 265 0.0456192872515251 287 2870194
SGTC_2922 7999257 32.47 µM 1.67531000875945 0.0477562264682708 no 266 0.046936711353267 285 2988377
SGTC_2219 9098279 200 µM 1.66700553473781 0.0485859949695991 no 267 0.0477566521647855 307 902349
SGTC_251 melphalan 456.522 µM 1.6669661795747 0.0485899545363762 no 268 0.0477605650214784 382 460612 A DNA alkylator.
SGTC_878 0828-0289 13.7 µM 1.66339254637433 0.0489505784137808 no 269 0.0481169420770287 419 745350 YLR208W SEC13
SGTC_2248 tofa 1.1 µM 1.66248256390018 0.0490427476858794 no 270 0.0482080282679934 307 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1063 disulfiram 1.84 µM 1.66156382586323 0.0491359443702651 no 271 0.0483001307606942 353 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_911 3456-4043 236 µM 1.66140343468302 0.0491522289270582 no 272 0.0483162242250593 383 914281
SGTC_1092 toremifene 6.32 µM 1.65818958950259 0.04947944085307 no 273 0.0486396026934491 400 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1107 amlodipine 47 µM 1.65358644817046 0.0499511274396219 no 274 0.049105784027341 366 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3157 9099274 49.47 µM 1.65128734510736 0.0501880570524257 no 275 0.0493399575411426 296 17217662
SGTC_876 0720-0963 56.8 µM 1.65044783966933 0.050274793610269 no 276 0.0494256866620001 360 765861
SGTC_2940 9060638 45.86 µM 1.64720605698252 0.0506108521540329 no 277 0.0497578496366743 370 4027022
SGTC_72 0744-0168 198.391 µM 1.64512147142771 0.050827893726543 no 278 0.0499723817730105 346 677577
SGTC_2031 5180455 200 µM 1.6438966634938 0.05095576274216 no 279 0.0500987747424816 299 29949
SGTC_938 3126-1755 342 µM 1.64095332070216 0.0512640926244757 no 280 0.0504035526595487 339 1777771
SGTC_887 0885-0007 9.62 µM 1.63723151185236 0.0516560937095322 no 281 0.0507910525417251 383 5719458
SGTC_1840 st055363 71 µM 1.6340696913121 0.0519909826775995 no 282 0.0511221090168216 313 676033
SGTC_3191 9110352 49.47 µM 1.63312338101203 0.0520915472513533 no 283 0.0512215250336333 301 17122424
SGTC_1765 st044815 90.4 µM 1.6325081729548 0.0521570083663068 no 284 0.0512862390831982 362 645695
SGTC_962 1254-0300 21.5 µM 1.63236337240576 0.0521724253407417 no 285 0.0513014801792024 346 7340576
SGTC_3286 9117135 37.221 µM 1.63111216751436 0.0523057924511558 no 286 0.0514333268654098 362 3438150
SGTC_1512 0259-0544 12.2 µM 1.62953920714995 0.0524738397066455 no 287 0.0515994609863529 396 18476
SGTC_2729 fluphenazine 10.66 µM 1.62684944809693 0.0527621929252706 no 288 0.0518845383165403 383 3372 An atypical antipsychotic.
SGTC_1176 0848-0131 83.3 µM 1.62515116782326 0.0529449020684333 no 289 0.0520651762351297 386 6769040
SGTC_2204 7233102 200 µM 1.61317654543896 0.054247471246084 no 290 0.0533530787885572 289 2172480
SGTC_70 0141-0289 43.283 µM 1.6068252147176 0.0549485730303409 no 291 0.0540463576794755 627 352408
SGTC_3256 9138902 49.47 µM 1.60677720337338 0.0549538999789645 no 292 0.0540516253788988 287 17228773
SGTC_1814 st052110 31.539 µM 1.60654582561814 0.054979577497123 no 293 0.0540770173376212 330 674163
SGTC_3181 9108277 49.47 µM 1.59284655927709 0.0565168457589545 no 294 0.0555973086709297 355 17097298
SGTC_2784 7567673 72.73 µM 1.59043502862476 0.0567909295321867 no 295 0.0558683899178772 420 3471247
SGTC_1991 st073000 8.92 µM 1.58967784728067 0.0568772029989838 no 296 0.0559537197859421 448 4301969 YIL048W NEO1
SGTC_22 0964-0034 14.468 µM 1.58890061795693 0.056965868051433 no 297 0.0560414158325266 417 138402
SGTC_934 2950-0684 338 µM 1.58697393239214 0.057186130483263 no 298 0.0562592743367491 395 1121253
SGTC_401 neomycin 50 µM 1.58510563767371 0.0574003571708602 no 299 0.0564711674502391 327 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_261 5-fluorouridine 15.376 µM 1.58062021658202 0.057917252425862 no 300 0.0569824502517566 374 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_404 fumagillin 50 µM 1.57673078473209 0.0583684220821715 no 301 0.0574287418790189 409 12015870 A methionine aminopeptidase binder.
SGTC_2962 9082311 13.18 µM 1.5750455140458 0.0585647666832644 no 302 0.0576229696188493 355 16459453
SGTC_615 k087-0205 167 µM 1.57209742938534 0.0589094836066773 no 303 0.0579639787941226 357 9642773
SGTC_1807 st050092 58.9 µM 1.57192276965941 0.0589299562624851 no 304 0.0579842315980588 363 5008496
SGTC_287 k060-0039 29.6 µM 1.56917009811119 0.0592533471347606 no 305 0.0583041548311751 361 5861974
SGTC_2144 5628481 200 µM 1.56666833252968 0.0595484665484064 no 306 0.0585961182476654 348 2818399
SGTC_2173 5763948 167 µM 1.5651229195769 0.0597313451699782 no 307 0.0587770452218689 399 2867177
SGTC_649 1123-0311 367 µM 1.55966148745264 0.0603811586000068 no 308 0.0594199488838189 452 693629 YIL048W NEO1
SGTC_3060 1327-0027 12.5 µM 1.55316813626659 0.061160936304494 no 309 0.0601914857612868 365 16000455 YPR107C YTH1
SGTC_37 0566-0070 1.56 µM 1.55160504060537 0.0613498165445082 no 310 0.0603783781673267 433 1626686
SGTC_3108 9121785 49.47 µM 1.53731506856671 0.0630977697950642 no 311 0.0621080866012461 392 17140271
SGTC_666 0272-0154 136 µM 1.53132332907163 0.0638421221882247 no 312 0.0628447513035382 444 6870312
SGTC_13 0199-0087 65 µM 1.52859838560497 0.0641828925565491 no 313 0.0631820182456294 418 4589825
SGTC_2388 9080168 200 µM 1.52808850323524 0.0642468131220293 no 314 0.0632452827671643 353 15943073
SGTC_1985 st071382 65.5 µM 1.52622653456245 0.064480656076607 no 315 0.0634767286893281 387 6123237
SGTC_2996 9066192 71.4286 µM 1.52616280608969 0.0644886713655061 no 316 0.0634846618999656 431 6472854
SGTC_3335 9143315 29.6265 µM 1.52424498875987 0.0647302423612596 no 317 0.0637237617426856 395 4899691
SGTC_1391 3442-0225 151 µM 1.51567917081401 0.0658177926477272 no 318 0.064800248500351 337 5227075
SGTC_914 3820-6779 408 µM 1.51213667481269 0.0662716802543691 no 319 0.0652495483069981 399 2893481
SGTC_1311 1190-0148 100 µM 1.50922382643101 0.0666467062689653 no 320 0.0656207966463615 513 1961333
SGTC_2092 5303694 80.6725 µM 1.50517341072589 0.0671709201166342 no 321 0.0661397496338629 447 1963699
SGTC_1147 3809-1045 12.3 µM 1.50342667562 0.0673979680182025 no 322 0.066364526001886 425 325925
SGTC_627 1391-0720 175 µM 1.50124172652709 0.0676828113304879 no 323 0.0666465255588253 410 997839
SGTC_2800 7887935 81.82 µM 1.49980860250662 0.0678701465899858 no 324 0.0668319941706694 401 2961002
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.49504002943592 0.068496369186713 no 325 0.0674519977463887 407 5355888
SGTC_1091 telmisartan 47.6 µM 1.49371471161667 0.0686712028537818 no 326 0.0676251008285192 438 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2409 alverine citrate 63.97 µM 1.49123408783242 0.068999367170376 no 327 0.0679500234928269 451 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_126 0417-1624 672.48 µM 1.48959377182189 0.0692170293007834 no 328 0.0681655403121098 530 41912 YDL195W SEC31
SGTC_214 4373-3496 70 µM 1.48900504794725 0.0692952790348509 no 329 0.0682430197348681 597 3779166
SGTC_2681 menadione 3.18 µM 1.48382140999963 0.0699872022683986 no 330 0.0689281527982134 427 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1761 st044296 37 µM 1.47091871479143 0.0717325597241963 no 331 0.070656550404078 431 1826700
SGTC_2468 5987765 72.9 µM 1.46612933754796 0.0723888524510145 no 332 0.0713065273111112 435 26772094
SGTC_2953 9074162 66.49 µM 1.46540539171671 0.0724884543999955 no 333 0.0714051736460032 385 16451992
SGTC_1285 0929-0069 65.5 µM 1.46312454009026 0.0728029451135687 no 334 0.0717166520298838 443 1206237
SGTC_3163 9099914 49.47 µM 1.46029235116623 0.0731949085435662 no 335 0.0721048716534917 342 16268368
SGTC_1242 0402-0103 60.1 µM 1.45985619123139 0.0732554145080401 no 336 0.0721648007438636 420 432868
SGTC_1905 st060207 84.5 µM 1.45636613428325 0.0737409489707321 no 337 0.0726457161045969 427 1948547
SGTC_3001 9076041 71.4286 µM 1.45489400622791 0.073946486570113 no 338 0.072849303710225 439 16004211
SGTC_881 0833-0569 170 µM 1.45327468599088 0.0741730803298619 no 339 0.0730737514015255 462 5418700
SGTC_3111 9122088 49.47 µM 1.45318552016016 0.0741855728184718 no 340 0.0730861256862089 321 16876704
SGTC_282 k297-0036 65.7 µM 1.45012287623803 0.074615637697943 no 341 0.0735121284324016 391 5061378
SGTC_2461 5755302 26.15 µM 1.44971078960558 0.074673648979673 no 342 0.0735695928345818 492 2788904
SGTC_218 alverine citrate 93.75 µM 1.44682901768611 0.07508029129607 no 343 0.0739724087304165 414 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2391 6285546 200 µM 1.44530727178344 0.0752957026771505 no 344 0.0741857981179691 481 846083
SGTC_755 1995-0008 37.3 µM 1.44443172225651 0.075419854795552 no 345 0.0743087864254631 445 689533
SGTC_2620 irigenin 100 µM 1.44310167491915 0.0756087527253351 no 346 0.0744959157998598 482 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2154 5570129 200 µM 1.44275034618786 0.0756587097819365 no 347 0.0745454055746313 497 673366
SGTC_2432 5630864 12.22 µM 1.43863441687133 0.0762458472032577 no 348 0.075127064874482 460 5714970
SGTC_491 tetrandrine 80.3 µM 1.43649357770144 0.0765526056599412 no 349 0.0754309712607105 384 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1689 st020265 53.493 µM 1.43603078330044 0.0766190421882042 no 350 0.0754967910042999 440 5758320 YPR016C TIF6
SGTC_2396 5342950 42.78 µM 1.43560326790714 0.0766804531888415 no 351 0.075557632162548 506 1886677
SGTC_2964 9083345 53.42 µM 1.43237675730327 0.0771451373440409 no 352 0.0760180133297562 419 17741579
SGTC_2114 5491910 81.25 µM 1.43190584098931 0.0772131375810974 no 353 0.0760853851967428 460 2849228
SGTC_2332 7982454 138.89 µM 1.42598271825976 0.07807232845242 no 354 0.0769366652737473 490 2981748
SGTC_3175 9106517 49.47 µM 1.425857200605 0.0780906138375559 no 355 0.0769547828770917 434 41468073
SGTC_2589 lobaric acid 100 µM 1.42452421190367 0.0782850038514414 no 356 0.0771473906993538 461 73157 A novel microtubule depolymerizer.
SGTC_1436 4092-1007 8.32 µM 1.42267741581472 0.0785549286035288 no 357 0.0774148452230381 437 2881121
SGTC_2236 dapsone 200 µM 1.42015727098339 0.0789244063341875 no 358 0.077780950068862 476 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1943 st076331 65.2 µM 1.41938986710544 0.0790371762585296 no 359 0.0778926924696414 471 24208415
SGTC_1324 1418-0026 34.4 µM 1.41480586277977 0.0797133382643523 no 360 0.0785627123419561 492 1372513
SGTC_710 3448-4187 58 µM 1.41365119788251 0.0798843446766709 no 361 0.0787321704596375 579 3946412
SGTC_2601 securinine 100 µM 1.40571924607813 0.0810665771404357 no 362 0.0799037548080884 461 442872 A GABA receptor antagonist.
SGTC_1353 1498-1206 8.11 µM 1.40532594295597 0.0811255395038511 no 363 0.0799621886501298 555 6756808
SGTC_3315 9136395 68.55 µM 1.40477320636366 0.0812084581589808 no 364 0.0800443644529107 488 16876844
SGTC_1317 1273-0028 910 nM 1.40459832840194 0.0812347057486706 no 365 0.0800703769943441 469 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_474 dl-dihydrosphingosine 5 µM 1.40445110059645 0.081256808263864 no 366 0.0800922816174516 480 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_483 fpl-64176 144 µM 1.40408769885554 0.0813113832241222 no 367 0.0801463680919427 389 3423
SGTC_1625 st003711 30.1 µM 1.40298028635682 0.0814778627808946 no 368 0.0803113588025606 466 24207034 YER133W GLC7
SGTC_1164 k060-0068 93.7 µM 1.39965443648053 0.0819793897867382 no 369 0.0808084121004508 523 5963676
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.3991999741467 0.0820481014359299 no 370 0.0808765121717318 506 165521
SGTC_374 0880-0231 82.3 µM 1.39911563851749 0.0820608571877022 no 371 0.0808891544246125 490 6833587
SGTC_2344 7990960 76.95 µM 1.39885953156765 0.082099602484493 no 372 0.0809275550393375 446 140813
SGTC_1059 3448-6867 171 µM 1.39722590415599 0.0823470711907627 no 373 0.081172824655508 472 3934407
SGTC_3023 9089636 49.47 µM 1.39490418087361 0.0826997413788847 no 374 0.0815223681010066 486 17249241
SGTC_2394 5221648 200 µM 1.39348335657717 0.0829161247833417 no 375 0.0817368372469857 554 788586
SGTC_473 2-arachidonoylglycerol 10 µM 1.39223667285879 0.0831063381429963 no 376 0.0819253704805758 482 5282280 An endocannabinoid.
SGTC_518 1021-0119 62.6 µM 1.39110323033181 0.0832795582998415 no 377 0.0820970627347761 495 1097762
SGTC_814 3342-0569 96 µM 1.3906741170558 0.0833452090052509 no 378 0.0821621348912233 532 4346283
SGTC_973 1325-0077 65.9 µM 1.38894840113146 0.0836096218210537 no 379 0.082424220496059 520 2835149
SGTC_2837 9008476 45.46 µM 1.38795735381159 0.0837617539440071 no 380 0.0825750157663688 516 2992805
SGTC_490 phenamil 164 µM 1.38371556444425 0.0844152460115853 no 381 0.083222782913547 364 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2386 9075165 157.42 µM 1.38350698154528 0.0844474787930776 no 382 0.0832547340564015 456 16452277
SGTC_2732 terfenadine 20 µM 1.37424914026657 0.0858874313359169 no 383 0.084682174913056 417 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3323 9138564 53.9225 µM 1.37348048615986 0.0860078079736714 no 384 0.0848015117787701 549 43912313 YNL103W MET4
SGTC_1574 spiramycin 23.7 µM 1.37328821063178 0.0860379394028028 no 385 0.0848313830912007 502 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2616 abietic acid 100 µM 1.37131235903554 0.0863480321270795 no 386 0.0851388023091755 523 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1284 0929-0043 16 µM 1.36996368171653 0.0865601747358202 no 387 0.0853491195096179 513 1239883
SGTC_460 trequinsin 123 µM 1.3669885272484 0.087029534311211 no 388 0.0858144507994156 508 5537 A vasodilator.
SGTC_1380 2291-0730 164 µM 1.36651943547486 0.0871037112643196 no 389 0.0858879924323587 459 2999191
SGTC_1124 fisetin 1.16336 µM 1.36367824513865 0.0875539948035599 no 390 0.0863344269404443 460 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_175 3793-3120 23.7 µM 1.3614552080358 0.0879075204058827 no 391 0.0866849397334957 469 5322297
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.35903110045165 0.0882942340546588 no 392 0.0870683668999343 544 688667
SGTC_1153 4055-0057 267 µM 1.3564780587591 0.0887028856450561 no 393 0.0874735559281576 511 882706
SGTC_1035 k081-0041 55.2 µM 1.35616016735602 0.0887538672580197 no 394 0.0875241063113965 539 731709
SGTC_508 roscovitine 141 µM 1.3525867929657 0.0893284466729665 no 395 0.088093837006544 495 160355 A CDKinase inhibitor.
SGTC_2694 st077685 81.9 µM 1.35153993337656 0.0894972990450211 no 396 0.0882612684424646 506 2838096
SGTC_441 propafenone 146 µM 1.34890459739957 0.0899234141801903 no 397 0.0886838056805328 454 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_295 k015-0027 31 µM 1.34665644590424 0.0902881145384752 no 398 0.0890454528517464 496 3887424
SGTC_1076 itraconazole 331 nM 1.34582387959912 0.0904234537527365 no 399 0.0891796611512389 532 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_486 niguldipine 82 µM 1.34562446546916 0.0904558922010189 no 400 0.0892118287086637 440 1236 A calcium channel blocker.
SGTC_786 4544-0069 423 µM 1.34559408539158 0.0904608348487489 no 401 0.0892167300864992 540 748821 YLR208W SEC13
SGTC_2999 9069765 71.4286 µM 1.34431757911494 0.0906686956660623 no 402 0.0894228566941193 542 2097066
SGTC_1053 3366-3204 134 µM 1.33469271464896 0.0922473924725835 no 403 0.0909884694927322 555 3632071 YPR165W RHO1
SGTC_69 0096-0274 206.684 µM 1.33251739894763 0.0926069959032275 no 404 0.0913451139899624 601 6741392
SGTC_1511 0906-3109 28.5 µM 1.33137287949442 0.0927966132727941 no 405 0.0915331743016949 633 2882180
SGTC_1473 k844-0725 134 µM 1.32869080752581 0.0932420878871706 no 406 0.0919749994635116 588 54682906
SGTC_257 daunorubicin 18.5 µM 1.3234798866146 0.0941121015798132 no 407 0.0928379203624358 479 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2540 epiandrosterone 100 µM 1.3230574155936 0.0941828988004782 no 408 0.0929081424125557 675 441302 A steroid.
SGTC_2884 9058502 51.95 µM 1.31502019515171 0.0955372595218115 no 409 0.094251557682397 545 6471554
SGTC_364 0083-0097 67.7 µM 1.31325978543052 0.095835812217396 no 410 0.094547712236618 530 5207356
SGTC_2805 7950783 58.44 µM 1.3123377953644 0.0959924485955564 no 411 0.0947030925287464 600 1178958 YDL195W SEC31
SGTC_2333 9017922 200 µM 1.31162565698667 0.0961135621895287 no 412 0.0948232358892262 535 3163164
SGTC_3234 9132280 49.47 µM 1.30984110314949 0.0964175552500631 no 413 0.0951247974801785 565 17612295
SGTC_807 1315-0151 48 µM 1.30579136967795 0.0971100341815974 no 414 0.0958117578787496 618 4011080
SGTC_2667 digitoxin 100 µM 1.30474145553861 0.0972901572729339 no 415 0.0959904501127521 441 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2755 lomerizine 42.69 µM 1.30156637346051 0.097836365179446 no 416 0.0965323305924729 563 3949 A calcium channel blocker.
SGTC_3042 9091578 49.47 µM 1.30000772183266 0.0981053203947356 no 417 0.0967991613126619 490 25236497
SGTC_1221 2958-7315 257 µM 1.29721639503583 0.0985883345388762 no 418 0.0972783705708306 547 4562705
SGTC_845 0330-0138 4.51 µM 1.29288825455967 0.0993407192994314 no 419 0.0980248551885385 551 9039800
SGTC_2360 9040895 200 µM 1.29181063225551 0.099528699385489 no 420 0.0982113662000234 510 4914414
SGTC_1430 4049-0248 69.1 µM 1.29158984961053 0.0995672447047017 no 421 0.0982496105341789 611 22774488
SGTC_365 0121-0052 13.6 µM 1.29078446637871 0.0997079449466713 no 422 0.0983892128214761 616 3101739
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.28914490505422 0.0999948246461936 no 423 0.0986738573393251 657 368090
SGTC_900 1112-0045 141 µM 1.28848068506726 0.100111216902758 no 424 0.0987893440736295 429 56211 YIL048W NEO1
SGTC_2433 5607874 27.82 µM 1.28731853739822 0.100315099640524 no 425 0.0989916424686914 552 2252428
SGTC_1272 0839-0021 27 µM 1.28713081865017 0.100348060706876 no 426 0.0990243476201866 577 5027250
SGTC_541 4513-1321 94 µM 1.28586946255049 0.100569744076973 no 427 0.0992443113998949 549 747515
SGTC_3228 9131799 49.47 µM 1.28537705953009 0.100656380807094 no 428 0.099330276845228 546 17015818
SGTC_662 k832-1615 104 µM 1.2844566117131 0.100818476611553 no 429 0.0994911178230947 546 5878478
SGTC_1737 st035557 69.7 µM 1.28393025733463 0.100911255948496 no 430 0.0995831795958624 458 5716916
SGTC_684 1140-0066 328 µM 1.28366926303252 0.10095728392326 no 431 0.0996288517654855 624 6813534
SGTC_191 3914-0123 66.505 µM 1.27862670561427 0.101849576836524 no 432 0.100514270539473 416 3144412
SGTC_3352 9151559 45.5865 µM 1.27601803742236 0.102313433752143 no 433 0.10097457149388 545 17159339
SGTC_194 1486-1323 56.904 µM 1.27496283562378 0.102501498864391 no 434 0.101161198289048 550 5178754
SGTC_1767 st044992 70.3 µM 1.27415863358534 0.102644997796839 no 435 0.101303601063135 564 9600693
SGTC_317 4495-0002 170 µM 1.27327938721365 0.102802054406791 no 436 0.101459459255863 508 15991618
SGTC_2803 7707263 71.43 µM 1.27240647200625 0.102958152775002 no 437 0.101614367868637 538 2199229
SGTC_2951 9072950 58.06 µM 1.27240027546095 0.102959261482451 no 438 0.101615468130514 596 16488155
SGTC_2770 toltrazuril 17.5 µM 1.27133424478324 0.103150128518435 no 439 0.101804882247828 600 68591 Kills coccidiodes.
SGTC_677 0929-0063 136 µM 1.26763604027493 0.103814263826415 no 440 0.102463977631863 498 1539583
SGTC_1559 coumarin 343 70.1 µM 1.26515946375193 0.104260745984122 no 441 0.102907085147321 519 108770 A hepatotoxic, DNA x-linker.
SGTC_2201 6605497 169.863 µM 1.26451071247119 0.104377933868077 no 442 0.103023389093024 526 670741
SGTC_1304 1165-0502 251 µM 1.2608968497846 0.105032474862949 no 443 0.103673006669846 629 767425
SGTC_1471 k673-0312 37 µM 1.25523404111554 0.106064086585987 no 444 0.104696905694786 551 24099884
SGTC_3275 9138069 49.47 µM 1.25497390688568 0.106111651312454 no 445 0.104744116190851 547 17617007
SGTC_1319 1306-0155 43.7 µM 1.25403388493214 0.106283659827486 no 446 0.104914844713025 638 3122360
SGTC_1085 doxorubicin 7.67 µM 1.25329872448617 0.10641832232817 no 447 0.105048506234757 620 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1707 st032323 6.317 µM 1.24664440788929 0.107642829336934 no 448 0.106263955534824 615 3132057 YMR211W DML1
SGTC_2213 7173844 200 µM 1.24583056431 0.107793284256506 no 449 0.106413303023677 609 892728
SGTC_1901 st060216 58.6 µM 1.24456511663971 0.108027527818783 no 450 0.106645824804288 601 688792
SGTC_1871 st057448 67.3 µM 1.24308142432083 0.108302636558793 no 451 0.106918915080555 617 691747
SGTC_1094 duloxetine 25.4 µM 1.23922900622261 0.109019311767862 no 452 0.107630350733174 581 60834 A selective serotonin reuptake inhibitor.
SGTC_2263 7948595 193.29 µM 1.23764054826507 0.109315807028929 no 453 0.107924686200084 517 2971371
SGTC_2569 tetrandrine 100 µM 1.23264125856093 0.110252734018282 no 454 0.108854818292224 528 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1296 1068-0102 11.9 µM 1.23053327587205 0.110649516656503 no 455 0.109248737039019 592 767053
SGTC_2764 methyldopa 94.69 µM 1.22846100876807 0.111040573121447 no 456 0.109636978882394 624 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1772 st048439 82.2 µM 1.22778859777141 0.111167675902513 no 457 0.109763168536413 604 2927068 YDL195W SEC31
SGTC_1384 3089-0840 101 µM 1.22430389031322 0.111828043189049 no 458 0.11041880495915 558 1069836
SGTC_862 0452-0056 10.2 µM 1.22288362511371 0.112097992822649 no 459 0.110686827091367 597 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_462 ag-879 158 µM 1.22247921893677 0.112174943390655 no 460 0.110763228894847 644 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_127 0180-0333 59.125 µM 1.21595068334459 0.113422423440682 no 461 0.112001854574197 694 771601
SGTC_2215 7188065 200 µM 1.2121311096373 0.114156843383246 no 462 0.112731098446603 546 940217
SGTC_2911 7942208 15.64 µM 1.21209902159821 0.114163027520043 no 463 0.112737239113474 557 1243384
SGTC_2734 clemastine 41.6 µM 1.20906665305297 0.114748514960041 no 464 0.113318619663206 455 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_122 0236-0016 402.397 µM 1.2075267117779 0.115046662258979 no 465 0.113614682180023 681 6808838
SGTC_1226 3909-7979 35.4 µM 1.20625794109148 0.115292721937528 no 466 0.113859024624136 664 6615510
SGTC_1816 st051957 91.6 µM 1.20525379748201 0.11548772603916 no 467 0.114052669937686 621 674121
SGTC_206 4546-0025 72.014 µM 1.20398433201945 0.115734590765639 no 468 0.114297817211299 705 6620745 YIL048W NEO1
SGTC_3011 9081274 71.4286 µM 1.20389357712163 0.115752253626781 no 469 0.114315357306348 659 6625322
SGTC_453 enantio-paf c16 10 µM 1.20360564445327 0.115808304208237 no 470 0.114371018409089 778 13871343 A lipid and platelet activating factor
SGTC_121 0557-0495 61.343 µM 1.20345191270056 0.11583823838138 no 471 0.114400744642177 780 3104427
SGTC_467 ro 31-8220 72.8 µM 1.20338571247984 0.115851130376654 no 472 0.114413547095835 647 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2366 9070441 60.58 µM 1.20180223898911 0.116159803625374 no 473 0.114720078896158 627 6837235
SGTC_1527 coumarin 137 µM 1.2001396657711 0.116484523790249 no 474 0.1150425513493 562 323 A hepatotoxic, DNA x-linker.
SGTC_1851 st056236 18.9 µM 1.1992894520812 0.116650829148141 no 475 0.115207707548241 643 5393171
SGTC_582 0987-0078 156 µM 1.19907793094339 0.11669222970897 no 476 0.115248822244898 756 1625765
SGTC_3347 9188721 44.724 µM 1.19521210174535 0.117450715601213 no 477 0.116002085759591 586 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1373 2887-0003 58.5 µM 1.19493133153994 0.117505939118601 no 478 0.116056930145322 595 776948
SGTC_3026 9090633 49.47 µM 1.1924896461268 0.117986959177305 no 479 0.116534654083137 621 25236842
SGTC_54 0159-0055 9 µM 1.18772955188811 0.118928714409478 no 480 0.117469988542741 621 3319099
SGTC_3159 9100096 49.47 µM 1.18697811840409 0.119077864680091 no 481 0.117618125851544 616 25236875
SGTC_2130 NSC 7 2.4545 µM 1.1862599688645 0.119220531869364 no 482 0.117759825110638 665 21448
SGTC_3105 9121040 49.47 µM 1.18034687417381 0.120399811355024 no 483 0.118931141091671 396 41448907
SGTC_2738 aclarubicin 5.55 µM 1.17828795768633 0.120812353937125 no 484 0.119340913497781 542 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_139 0099-0334 718.624 µM 1.17681989653026 0.121107114499006 no 485 0.11963369972525 736 97690
SGTC_1136 pergolide 1.05886 µM 1.17630051945565 0.121211517224276 no 486 0.119737404138234 735 47811 A dopamine receptor agonist.
SGTC_3305 9127027 53.8275 µM 1.16983288986345 0.1225169135409 no 487 0.121034112530821 642 41905295
SGTC_1344 1488-0097 29.1 µM 1.16925697515048 0.122633629978848 no 488 0.121150056074391 632 747966
SGTC_248 streptozotocin 5.23457 mM 1.1677414586254 0.12294114130232 no 489 0.121455534113918 677 5300 DNA alkylating agent.
SGTC_1313 1220-0047 237 µM 1.16674008591964 0.123144624823007 no 490 0.121657674616944 691 3528706
SGTC_311 1315-0136 58 µM 1.16610332198368 0.123274140880451 no 491 0.121786336857047 671 6759207
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.1658535989179 0.123324959921795 no 492 0.12183682109408 681 2724 A muscle relaxant with antifungal properties.
SGTC_1745 st081495 74 µM 1.1651314361333 0.12347200379166 no 493 0.121982896891485 712 13842402 YBL026W LSM2
SGTC_423 5-fluorouracil 457 µM 1.16491972375738 0.123515135079938 no 494 0.122025744413009 628 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1358 1509-0022 2.48 µM 1.16032341391968 0.124454124603647 no 495 0.122958577580188 657 3258434
SGTC_2867 9039098 71.43 µM 1.15965430693004 0.124591232923445 no 496 0.123094790379971 654 6463460
SGTC_455 paf C-16 10 µM 1.15873785725009 0.124779196127508 no 497 0.123281527314957 626 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2892 9047358 58.44 µM 1.15808950325333 0.124912292717056 no 498 0.12341375656831 610 6466771
SGTC_2030 5175110 200 µM 1.15786390125661 0.124958628410434 no 499 0.123459790502133 659 2831986
SGTC_1423 4048-0112 5.59 µM 1.15783205478695 0.124965170224905 no 500 0.123466289721224 653 X1423
SGTC_2211 7117706 200 µM 1.15781911454501 0.124967828442275 no 501 0.123468930630842 626 822771
SGTC_2570 licareol 100 µM 1.15671778896913 0.125194210293504 no 502 0.123693839692812 649 443158
SGTC_1308 1187-1617 41.4 µM 1.1555005140804 0.125444758979339 no 503 0.123942761107751 699 2882570
SGTC_849 0386-0493 241 µM 1.1498817584637 0.126605788615314 no 504 0.125096287513506 631 726119
SGTC_1021 4476-0760 85.3 µM 1.14901676764463 0.1267851883354 no 505 0.125274533325826 649 746768
SGTC_1054 3429-0080 167 µM 1.14403892055676 0.127821037324078 no 506 0.126303748174556 682 1162877
SGTC_578 3460-0051 92 µM 1.14241993897841 0.128159198039497 no 507 0.126639753601341 749 2876744
SGTC_2147 5545932 89.7195 µM 1.13947024363601 0.128776904444255 no 508 0.127253536263919 641 797404
SGTC_2137 5261020 140 µM 1.13842030613663 0.128997273294071 no 509 0.127472509437627 651 763655
SGTC_885 0865-0106 16.8 µM 1.13596706112099 0.129513197933265 no 510 0.127985175009869 666 2793380
SGTC_1997 st073024 93.8 µM 1.13486508500383 0.129745411431228 no 511 0.128215925493468 663 686268
SGTC_2657 nystatin 74.44 µM 1.13451234863084 0.12981980255 no 512 0.128289848432446 708 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_651 3253-0966 34.4 µM 1.13074972464584 0.130615167413137 no 513 0.1290802229946 704 781462
SGTC_2865 9030313 51.95 µM 1.12873973898794 0.131041427483237 no 514 0.129503820108075 623 42562754
SGTC_3090 9117696 49.47 µM 1.12870914873834 0.131047922210238 no 515 0.129510274322711 664 7923821
SGTC_1550 gossypolone 36.6 µM 1.1276341547071 0.131276299331566 no 516 0.129737228067725 693 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_136 0097-0015 404.482 µM 1.12629343664051 0.131561513149465 no 517 0.130020667486134 732 4861337
SGTC_1481 3346-2004 36 µM 1.12606414554448 0.131610333529566 no 518 0.130069184497712 702 2770522
SGTC_794 k038-0031 316 µM 1.12562680867381 0.131703485425506 no 519 0.130161757839912 776 6624242
SGTC_1763 st044482 94.5 µM 1.1253934509574 0.131753208771715 no 520 0.1302111725167 698 88505
SGTC_523 1934-0222 13.7 µM 1.12395781354762 0.132059396168249 no 521 0.130515461565542 696 1361595
SGTC_1505 k297-0037 20.6 µM 1.12326651109089 0.132207009472201 no 522 0.130662161136877 695 4089396
SGTC_607 4491-0986 66.8 µM 1.12079416631739 0.13273585808828 no 523 0.13118774395289 703 698981 YDR232W HEM1
SGTC_2194 5927483 104.545 µM 1.11963479565753 0.132984355215124 no 524 0.131434710734861 724 760979
SGTC_1218 1348-1416 30.7 µM 1.11783008263902 0.133371810635596 no 525 0.131819785392465 679 6787668
SGTC_1184 1269-1718 139 µM 1.11549665013625 0.133873927472793 no 526 0.132318826576536 694 5403821
SGTC_2490 carminic acid 95.39 µM 1.11486602969459 0.134009849485302 no 527 0.132453917886941 595 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_79 0052-0007 94.094 µM 1.1109546735466 0.134855009068489 no 528 0.133293930012784 715 2801472
SGTC_3171 9103192 49.47 µM 1.10641162628807 0.13584124486586 no 529 0.134274197782381 683 13018434
SGTC_660 4031-1742 102 µM 1.10310773787887 0.136561570314054 no 530 0.134990190466441 724 6738706
SGTC_340 k038-0059 454 µM 1.09875190748993 0.137515229633904 no 531 0.135938147277387 713 23733424
SGTC_339 3091-4833 71.4 µM 1.09696256111197 0.137908300910734 no 532 0.136328879284391 711 3240077
SGTC_428 3448-4153 16.5 µM 1.09675838607991 0.137953201343807 no 533 0.136373512915881 618 3834874
SGTC_179 1273-0063 6.77 µM 1.09544998635551 0.138241170147543 no 534 0.136659772596389 650 3108139
SGTC_3257 9139206 32.98 µM 1.09515768294459 0.138305559863247 no 535 0.136723780627635 666 4910041
SGTC_967 1306-0166 352 µM 1.09406413745446 0.138546631547449 no 536 0.136963424844576 710 4437607
SGTC_1832 st054113 55 µM 1.09128399105637 0.139160802359833 no 537 0.137573969899206 685 1251267
SGTC_2352 9027995 87.8 µM 1.08955754292799 0.139543128640701 no 538 0.137954047041338 653 2997347
SGTC_2070 5230947 200 µM 1.08866237735237 0.139741646277417 no 539 0.138151399235904 748 2835538
SGTC_1624 st003710 6.25 µM 1.08863860934475 0.139746919837933 no 540 0.138156641859071 766 24207033
SGTC_2482 5981709 142.65 µM 1.08433370619296 0.140704308282609 no 541 0.139108432828306 739 877755
SGTC_2857 9024691 58.44 µM 1.08430861921137 0.14070990051252 no 542 0.139113992473681 671 16478292
SGTC_3188 9110789 49.47 µM 1.08257992102994 0.141095614201137 no 543 0.139497461807313 715 849217
SGTC_1915 st067105 30.6 µM 1.08235277728728 0.141146348617225 no 544 0.139547901469476 713 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3284 9108171 64.8615 µM 1.08163702239539 0.141306299231373 no 545 0.139706923502864 690 8687505
SGTC_689 0833-0039 98 µM 1.08097996239035 0.141453241356144 no 546 0.13985301349089 750 5374726
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.079876825008 0.141700175131672 no 547 0.140098517255891 662 521171
SGTC_3010 9080089 71.4286 µM 1.07766507484804 0.142196147473978 no 548 0.140591624915974 731 17027233
SGTC_329 k048-0121 21.3 µM 1.07612188501297 0.142542893963109 no 549 0.140936374590898 705 6832902
SGTC_3180 9109287 49.47 µM 1.07505525103172 0.142782894847457 no 550 0.141174996241921 670 18891271
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.06940259890827 0.14405934325943 no 551 0.142444148379984 792 16486 A toxic proline analog.
SGTC_1254 0550-0035 264 µM 1.06887963629288 0.144177823268575 no 552 0.142561954483708 784 15121435
SGTC_1419 3993-2473 62.6 µM 1.06644372694854 0.144730557216712 no 553 0.143111551977783 741 704026
SGTC_2774 tamoxifen 10.92 µM 1.06442009086854 0.145190825848446 no 554 0.143569218190612 735 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.06277604522958 0.145565482415899 no 555 0.143941762652904 752 5282309
SGTC_1795 st049545 62.3 µM 1.06214692288819 0.145709023027872 no 556 0.144084495546343 731 5291882
SGTC_1653 st012112 65 µM 1.06209440272556 0.14572101033494 no 557 0.144096415436681 700 720429
SGTC_2988 9073640 71.4286 µM 1.06207637073594 0.145725126145227 no 558 0.144100508100931 693 9102229
SGTC_2945 9067681 61.76 µM 1.05933207019214 0.146352425099291 no 559 0.144724287198175 717 16456930
SGTC_2646 retinol 96.75 µM 1.05773609154864 0.146718070419131 no 560 0.145087888039457 721 445354 A vitamin A analog and teratogen.
SGTC_2860 9025725 38.96 µM 1.05331769629956 0.147733538106397 no 561 0.146097705529993 702 40546248
SGTC_2859 9028643 45.46 µM 1.05283316504171 0.147845182283515 no 562 0.146208730983005 714 17151580
SGTC_3288 9119690 36.221 µM 1.04945440950272 0.148625274681537 no 563 0.146984513813096 683 17595618 YKL019W RAM2
SGTC_1504 k297-0033 30 µM 1.04913229062919 0.148699789407656 no 564 0.147058618134553 619 4388117
SGTC_31 0508-1974 57.237 µM 1.04303548739559 0.150114852569498 no 565 0.148465928633236 742 6810525
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.04184177493016 0.150392959712638 no 566 0.148742521262377 786 3256 An antibiotic and ribosome inhibitor.
SGTC_940 3232-1287 54.8 µM 1.03979919797647 0.15086962824431 no 567 0.149216600910226 778 1585493 YIL048W NEO1
SGTC_2455 5377712 9.75 µM 1.03796987069793 0.151297384262533 no 568 0.149642041158432 679 2243908
SGTC_2108 5365811 200 µM 1.03359479710621 0.152323686966294 no 569 0.150662816363814 786 780283
SGTC_3224 9130643 49.47 µM 1.03063225120832 0.153021257655785 no 570 0.151356653046705 726 17644395
SGTC_1197 1601-0112 267 µM 1.03000890520716 0.153168301975868 no 571 0.151502912623238 784 7350313
SGTC_1207 2099-0101 141 µM 1.02976066362514 0.153226887033128 no 572 0.151561185253856 824 5837381
SGTC_2661 dactinomycin 12.96 µM 1.02791580814244 0.153662738426756 no 573 0.151994716399916 812 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2931 9014674 55.67 µM 1.02688526181421 0.153906564374715 no 574 0.152237247486917 743 2996810
SGTC_667 1498-1044 59 µM 1.02601829193274 0.154111886539426 no 575 0.152441481014204 797 6739982
SGTC_1439 4092-1168 46 µM 1.02454241148575 0.154461831968925 no 576 0.152789574672134 790 2886240
SGTC_3078 9116413 49.47 µM 1.02163775656074 0.155152086653748 no 577 0.153476190339043 716 17177322
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.01690531292591 0.156281047473331 no 578 0.154599237832145 767 616764
SGTC_1170 0310-0127 64.8 µM 1.01512508741374 0.156707131154557 no 579 0.155023102131393 804 774975
SGTC_1578 josamycin 24.2 µM 1.01253976098328 0.15732726992786 no 580 0.155640022800257 722 5282165 A P450 substrate.
SGTC_2089 5281248 129.67 µM 1.01131194980041 0.157622347597171 no 581 0.155933574225267 793 2737878
SGTC_2692 st077426 47.7 µM 1.01126952096923 0.157632550937909 no 582 0.155943724848471 809 25238571
SGTC_979 1426-2828 121 µM 1.01063362901026 0.15778552305272 no 583 0.156095907065142 837 747872
SGTC_1122 capsaicin 818.572 nM 1.00967922614812 0.158015300052229 no 584 0.156324499197274 809 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2810 7959871 45.46 µM 1.00925767000061 0.158116861595885 no 585 0.15642553765061 848 2974535
SGTC_2943 9068529 45.32 µM 1.00723635323191 0.158604433492227 no 586 0.156910603617121 868 3270634
SGTC_1332 1480-0653 17.5 µM 1.00561752313675 0.158995629794465 no 587 0.15729979565059 797 5749438
SGTC_1854 st056233 32.9 µM 1.00476580447082 0.159201704380575 no 588 0.157504816687842 778 5393174
SGTC_2761 levamisole 97.89 µM 1.00412130667155 0.159357757794796 no 589 0.157660073321149 773 26879 An alkaline phosphatase inhibitor.
SGTC_3303 9125618 40.5795 µM 1.00374836162943 0.159448105382954 no 590 0.157749960018587 862 22695467
SGTC_1163 k060-0048 49.9 µM 1.00042312218089 0.160255141469074 no 591 0.158552892411083 828 6809982
SGTC_1711 st032263 62.8 µM 0.998912351596389 0.160622686235441 no 592 0.158918576126822 780 3958979
SGTC_2558 carylophyllene oxide 100 µM 0.998265714789114 0.160780170091731 no 593 0.159075264073417 856 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2134 5324836 1.464 µM 0.997577937645738 0.160947783994461 no 594 0.159242031860295 743 699272
SGTC_208 k072-0098 12.366 µM 0.994320004047215 0.161743303948678 no 595 0.160033549918995 904 5948901
SGTC_2153 5569715 200 µM 0.992797290133666 0.1621159964048 no 596 0.160404375405134 798 2054701
SGTC_3229 9132204 49.47 µM 0.991271377079709 0.162490032426264 no 597 0.160776542762878 801 17682924
SGTC_519 k048-0011 62.8 µM 0.99073908050194 0.162620642445709 no 598 0.160906501448347 799 6836379
SGTC_1209 2323-2347 50.3 µM 0.98794026912138 0.163308512279001 no 599 0.161590951083429 818 5412760
SGTC_2243 6634756 200 µM 0.985587721408371 0.163888163027094 no 600 0.162167732877988 780 885676
SGTC_2290 7904846 200 µM 0.985473814970067 0.163916262596154 no 601 0.162195693674767 793 2962154
SGTC_3085 9117376 49.47 µM 0.983271209763196 0.164460237730683 no 602 0.162736987887687 822 16480349
SGTC_552 k242-0005 476 µM 0.983253447081295 0.164464629312812 no 603 0.162741357869283 800 4088318
SGTC_976 1348-1067 47.6 µM 0.982994656581277 0.164528620374088 no 604 0.162805034260554 876 5310671 YGL099W LSG1
SGTC_752 1896-0090 130 µM 0.982333677176197 0.164692133813595 no 605 0.162967744299724 836 772567
SGTC_2985 9022375 71.43 µM 0.982178117944873 0.164730631439397 no 606 0.163006052911082 824 4939335
SGTC_2853 9015042 58.44 µM 0.98199255459576 0.16477656207539 no 607 0.163051758107165 742 6457456
SGTC_2091 4-phenylthiadiazole 200 µM 0.981051114495473 0.165009715102833 no 608 0.163283767912256 830 270010
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.980761862781108 0.165081392820546 no 609 0.163355094559371 805 803109
SGTC_1605 st000082 49.1 µM 0.980556572987392 0.165132276670268 no 610 0.163405729295458 838 1114022
SGTC_47 0149-0135 24.25 µM 0.979302039119503 0.16544345041221 no 611 0.1637153816107 843 5239155
SGTC_2722 naftopidil 47.16 µM 0.979072084128197 0.16550052940641 no 612 0.16377218189981 840 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1212 0520-0165 585 µM 0.978409649562354 0.165665028856276 no 613 0.163935878777079 791 5403258
SGTC_1673 st016611 27.3 µM 0.977394697442566 0.165917272451782 no 614 0.164186893564692 851 5226799
SGTC_1812 st052057 4.327 µM 0.975624121981562 0.166357903179345 no 615 0.164625383140456 847 3645418
SGTC_2595 hexamethylquercetagetin 100 µM 0.974555103288799 0.166624307885899 no 616 0.164890496626942 761 386331
SGTC_2115 tiliquinol 12.7705 µM 0.974278997392483 0.166693159546439 no 617 0.164959014980674 814 71208 A bioactive hydroxyquinoline.
SGTC_624 k048-0052 28 µM 0.973803535731357 0.166811766949871 no 618 0.165077048603374 788 6835531
SGTC_1389 3405-0187 19 µM 0.97137118618388 0.167419385870212 no 619 0.165681735820152 758 799890
SGTC_89 0302-0250 142.109 µM 0.969587416673 0.167865889963159 no 620 0.166126093813416 893 4203518 YLR208W SEC13
SGTC_2279 7948423 32.93 µM 0.968021433942034 0.1682585101184 no 621 0.166516832611938 793 1247112
SGTC_3169 9102970 49.47 µM 0.966883803053358 0.168544104863779 no 622 0.166801062219826 856 17027839
SGTC_1343 1487-0095 224 µM 0.966215739465809 0.168711962985729 no 623 0.166968119307332 846 4560101 YGL055W OLE1
SGTC_1678 st019265 80.2 µM 0.965187822810609 0.168970447797968 no 624 0.167225372520942 864 5367020
SGTC_553 k007-0256 45.7 µM 0.964589868286384 0.169120929255098 no 625 0.167375138049512 841 6287000
SGTC_1797 st048695 56.8 µM 0.963265360956064 0.16945456158916 no 626 0.167707185898372 842 592262 YIL048W NEO1
SGTC_3002 9075603 71.4286 µM 0.963091319765183 0.169498432485656 no 627 0.167750848730178 865 20105405
SGTC_1699 st031318 29.054 µM 0.959902893361266 0.170303434741112 no 628 0.168552044941962 864 5340658
SGTC_989 1501-0895 10.3 µM 0.958594652247082 0.170634442141977 no 629 0.168881493826041 867 2830112
SGTC_1907 st060210 83.7 µM 0.958058004978264 0.170770342134731 no 630 0.169016755038139 912 688793
SGTC_2281 7943571 200 µM 0.957250269719311 0.170975022725768 no 631 0.169220474751741 924 1244024
SGTC_1442 4112-3290 3 µM 0.957154944248292 0.170999188605888 no 632 0.16924452727957 872 704353
SGTC_993 3909-8757 62.7 µM 0.954998059541567 0.171546562600181 no 633 0.169789339129521 774 4288324 YLR208W SEC13
SGTC_2507 purpurin 79.67 µM 0.954918100157013 0.171566876184204 no 634 0.16980955782737 844 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_707 0865-0008 204 µM 0.954747830737221 0.171610138043381 no 635 0.169852617654426 896 723043
SGTC_1845 st056753 3.01 µM 0.953434698358383 0.171944011324707 no 636 0.170184933906063 850 5375839
SGTC_1569 carminic acid 40.6 µM 0.951900675780196 0.172334572382237 no 637 0.170573678398903 883 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_970 1315-0089 19.5 µM 0.951515589726799 0.17243270381722 no 638 0.170671354225718 797 6811083 YLR033W RSC58
SGTC_2910 7948405 25.97 µM 0.950075915229367 0.17279989152806 no 639 0.171036840052421 813 2971328
SGTC_2374 9071832 200 µM 0.944946926119305 0.174112082263546 no 640 0.172342986284202 849 17381698
SGTC_2452 5863136 48.41 µM 0.944382956255864 0.174256752752706 no 641 0.172486993924569 841 2184096
SGTC_51 1013-0126 23.419 µM 0.943552069756055 0.174470032267575 no 642 0.172699297526272 828 1627850
SGTC_719 2810-4230 27.3 µM 0.942156660401903 0.174828591528837 no 643 0.173056219563908 831 721079
SGTC_3055 9094636 49.47 µM 0.941789554915522 0.174922999258671 no 644 0.173150196936292 836 25236176
SGTC_258 haloperidol 50.781 µM 0.940869214469822 0.175159823421847 no 645 0.173385942854855 832 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1768 st044301 37.178 µM 0.940144143430641 0.175346543554813 no 646 0.173571814190931 882 3931349
SGTC_202 3594-0513 34.79 µM 0.938159542041158 0.175858262811442 no 647 0.174081213250906 821 708429
SGTC_1826 st055655 41.6 µM 0.934970535478117 0.176682510523164 no 648 0.174901742127541 868 676168
SGTC_66 0109-0187 42.4 µM 0.934808168847374 0.176724541918248 no 649 0.174943584492714 788 759417
SGTC_626 0214-0009 33 µM 0.934585215214531 0.176782267599957 no 650 0.175001050657658 906 3437874
SGTC_338 4055-0136 114 µM 0.934215839972573 0.17687793002594 no 651 0.175096283259196 864 2900563
SGTC_1298 1079-1278 263 µM 0.932273411984202 0.177381526825875 no 652 0.17559762234518 896 2840950
SGTC_2062 5245942 200 µM 0.930754725823141 0.177775893605015 no 653 0.175990226983499 954 1376160
SGTC_2829 7992743 58.44 µM 0.92666869193224 0.178839683086608 no 654 0.17704928880568 896 16462845
SGTC_2707 st078556 66.6 µM 0.923446414091029 0.179681415368849 no 655 0.177887306704089 883 17250899
SGTC_1836 st055642 81 µM 0.922722670938638 0.179870815343966 no 656 0.178075874102607 902 8571
SGTC_3094 9117742 49.47 µM 0.920646235701319 0.180414903723372 no 657 0.178617577274567 958 17149698
SGTC_2009 4012297 12.05 µM 0.917283394035308 0.181298256778181 no 658 0.179497078412042 819 45595307
SGTC_1597 7-benzyloxygramine 47.5 µM 0.917143026539413 0.181335187376696 no 659 0.17953384852562 974 260807
SGTC_1064 honokiol 6.76 µM 0.916985113310406 0.18137673987642 no 660 0.179575220508559 889 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1695 st026914 34.495 µM 0.915534013922704 0.181758853980198 no 661 0.179955677220774 886 3289191
SGTC_336 4111-0029 111 µM 0.914618487048365 0.18200019612376 no 662 0.18019597500156 827 3131175
SGTC_2586 curcumin 80 µM 0.914008006700608 0.182161236217774 no 663 0.180356319274607 958 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2024 5144227 134 µM 0.913115306913844 0.18239688395659 no 664 0.18059095034099 936 3475211
SGTC_532 1548-0774 215 µM 0.911138043779161 0.182919503745407 no 665 0.18111132175575 949 5932993
SGTC_2665 lovastatin 100 µM 0.910761744108418 0.18301907104114 no 666 0.181210461700348 876 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_275 trichlorophene 5.69 µM 0.908622489702355 0.183585751027117 no 667 0.181774715527871 989 62616
SGTC_1486 3970-0793 4.53 µM 0.908417447375153 0.18364012328985 no 668 0.181828855546693 928 2844330
SGTC_3020 9089140 49.47 µM 0.907702166045056 0.183829877132822 no 669 0.182017799625273 913 17217859
SGTC_2098 5376439 882.5 nM 0.907636882661741 0.183847201954645 no 670 0.182035050571938 947 2844116
SGTC_1424 4048-1941 275 µM 0.907162149716657 0.183973216567982 no 671 0.182160528133368 996 X1424
SGTC_2522 biochanin a 4.94 µM 0.906282321756148 0.184206903046419 no 672 0.182393220029336 893 5280373 A possible chelator.
SGTC_189 3970-0742 2.116 µM 0.901392922546807 0.185508914021279 no 673 0.183689721545841 934 2891807
SGTC_538 2922-0838 53.3 µM 0.899426672712519 0.186034118222552 no 674 0.184212718638232 982 777039
SGTC_2323 6148992 148.28 µM 0.898489926624155 0.186284655964558 no 675 0.184462206611183 818 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_992 3909-8734 162 µM 0.898188375030517 0.186365352009737 no 676 0.184542564958666 893 4288319
SGTC_1159 4092-0538 61.2 µM 0.897572466274022 0.186530238179095 no 677 0.184706761752168 959 717301
SGTC_465 cgp-37157 41 µM 0.895896987968421 0.186979240809233 no 678 0.185153891500648 806 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2226 7298446 200 µM 0.895490549207541 0.187088260895168 no 679 0.185262457803202 899 3283010
SGTC_369 0957-0393 4.5 µM 0.893739231617892 0.18755847076353 no 680 0.185730714775906 868 6997992
SGTC_349 k015-0014 24 µM 0.8912036470269 0.188240540526414 no 681 0.18640996411452 856 2196908
SGTC_1809 st050081 57.6 µM 0.890999996870751 0.188295388534934 no 682 0.186464585956485 918 5036894
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.89081895519999 0.188344155798328 no 683 0.18651315220668 928 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1804 st050076 49.1 µM 0.88877864661432 0.188894293050988 no 684 0.187061027021372 916 3895976
SGTC_27 0485-0001 32.618 µM 0.887694691639437 0.189186966839173 no 685 0.187352501051492 871 2054479
SGTC_917 harmaline 728.087 nM 0.884957441868342 0.189927281225307 no 686 0.188089792608483 913 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2641 levomentholum 100 µM 0.884733203930128 0.189988007261948 no 687 0.18815027144873 906 16666
SGTC_1529 apigenin 74 µM 0.884191076285407 0.190134870536913 no 688 0.188296537364514 945 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3220 9131269 49.47 µM 0.883780756487674 0.190246073216633 no 689 0.188407288179226 925 17722206
SGTC_289 k017-0060 526 µM 0.882423537967672 0.190614183899762 no 690 0.188773905810117 936 5512909
SGTC_2560 caryophyllene 100 µM 0.882097364767947 0.190702715128563 no 691 0.188862078585088 1054 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1694 st024011 44.9 µM 0.881370400487005 0.19090012144984 no 692 0.189058686503999 983 2787533
SGTC_1721 st082152 9.2685 µM 0.879261268521337 0.191473562915868 no 693 0.189629815554493 898 5296051
SGTC_2312 7706453 155.7 µM 0.879139729548854 0.191506639676338 no 694 0.18966275924252 908 976098
SGTC_516 3992-2719 87.3 µM 0.878904369415367 0.191570702752064 no 695 0.189726564679672 953 5350887 YDR037W KRS1
SGTC_750 4073-0104 132 µM 0.878573009458489 0.191660918431889 no 696 0.189816417759592 790 22330957
SGTC_10 0279-0212 42.575 µM 0.87838699848735 0.191711572965487 no 697 0.18986686880985 1026 39851 YBR002C RER2
SGTC_777 1315-0167 517 µM 0.877020035271432 0.192084076028273 no 698 0.190237877929988 875 4221767
SGTC_2687 chenodiol 100 µM 0.875764393506001 0.192426633496387 no 699 0.190579065328668 888 5702181 A cholesterol synthesis inhibitor.
SGTC_1047 2043-3044 82 µM 0.875714466964518 0.192440261905143 no 700 0.190592639304892 978 669592
SGTC_1445 4239-0156 97.7 µM 0.87512133545655 0.192602213693683 no 701 0.190753944687402 1020 4008346
SGTC_1208 2323-2347 50.3 µM 0.874476034608652 0.192778504659891 no 702 0.190929532931508 959 5412760
SGTC_2592 piperlongumine 83.33 µM 0.874180404668858 0.192859301282643 no 703 0.191010007805942 875 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2048 5246248 200 µM 0.874129061377016 0.192873335678989 no 704 0.191023986334949 954 677046
SGTC_2192 5915882 198.485 µM 0.87198859602715 0.193458974675996 no 705 0.191607299439539 923 2876149
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.868695540010896 0.194362082160009 no 706 0.192506840762696 967 688669
SGTC_1352 1496-0991 99 µM 0.866972598459148 0.194835613105896 no 707 0.192978511788794 952 3000039
SGTC_2836 9010338 19.48 µM 0.865823699377431 0.195151764584398 no 708 0.193293425295566 912 2994051
SGTC_3350 9150499 3.57 µM 0.864315283924116 0.195567320063196 no 709 0.193707358177775 1000 4910996 YPR165W RHO1
SGTC_2746 daunorubicin 9.88 µM 0.861576047306757 0.196323328700571 no 710 0.194460428286866 836 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1195 1502-0147 41.1 µM 0.861349762118005 0.196385860826952 no 711 0.194522718131127 1000 817940
SGTC_2888 9058547 12.99 µM 0.857912034229743 0.197337333943392 no 712 0.195470519290022 865 16476514
SGTC_3185 9108267 49.47 µM 0.8570480774511 0.197576892261637 no 713 0.195709157390004 978 4910486
SGTC_481 bay k-8644 50 µM 0.856229397248368 0.197804058415551 no 714 0.195935452519696 894 2303 A calcium channel antagonist.
SGTC_1199 1638-0010 4.46 µM 0.855377895995845 0.198040499055726 no 715 0.196170988218439 939 3111136
SGTC_412 gemfibrozil 100 µM 0.854959204198932 0.198156821881853 no 716 0.1962868664511 937 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2170 morpholine 200 µM 0.854245384213065 0.198355233626231 no 717 0.19648452078771 961 121171 Reacts with secondary amines.
SGTC_2766 oltipraz 83.91 µM 0.849149400107385 0.199775181477762 no 718 0.197899082508321 937 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2873 9040596 71.43 µM 0.848781350044926 0.199877971364366 no 719 0.198001484824306 988 6463863
SGTC_2649 anisomycin 9.56 µM 0.846541864348315 0.200504105489872 no 720 0.198625264877001 956 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_709 3807-1509 243 µM 0.845602825979761 0.200766999814483 no 721 0.198887174263055 985 1886677 YPL242C IQG1
SGTC_2847 9005661 71.43 µM 0.844665969985293 0.2010294892188 no 722 0.199148682286017 886 2991449
SGTC_2720 fluspirilene 36.88 µM 0.844060887006019 0.201199131435286 no 723 0.19931769133659 914 3396 An atypical antipsychotic.
SGTC_601 0986-0029 62.9 µM 0.843791410553813 0.201274709985294 no 724 0.199392988073874 987 24747981
SGTC_91 0417-1751 58.384 µM 0.843196394284788 0.201441651133636 no 725 0.199559307339631 1129 6795624
SGTC_2364 9055074 200 µM 0.842216183426031 0.201716845543668 no 726 0.199833478400429 953 6470630
SGTC_176 1486-1328 72.834 µM 0.840546777458911 0.202186049589293 no 727 0.200300942787708 1013 22310231
SGTC_3059 1327-0034 3 µM 0.839144587026131 0.202580653999885 no 728 0.200694089142033 942 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2233 sulbentine 40.3845 µM 0.836004915008106 0.203465888185007 no 729 0.201576069012391 1024 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_675 1309-0189 238 µM 0.834455523597388 0.203903589937753 no 730 0.20201217014479 962 4246530
SGTC_2418 pentamidine 31.67 µM 0.833156635532503 0.204270956732979 no 731 0.202378197839429 1000 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1539 benzyladenosine 56 µM 0.833134384913236 0.204277253346267 no 732 0.202384471535002 1003 92208 A nucleotide analog.
SGTC_3341 9147222 25.867 µM 0.83200843972416 0.204596030915123 no 733 0.202702090360624 948 1939759
SGTC_1392 3455-1037 33.9 µM 0.83036674968811 0.205061356184878 no 734 0.203165729495592 970 981132
SGTC_1974 st069448 26.9 µM 0.829307861223643 0.205361823951856 no 735 0.203465111838098 1013 6323587 YNR016C ACC1
SGTC_3292 9120825 59.784 µM 0.828727437168164 0.205526634648204 no 736 0.203629328275436 1029 24824900
SGTC_1963 st076565 50.3 µM 0.828129973393323 0.205696365747919 no 737 0.203798448196664 994 4914280
SGTC_1376 2910-0861 41.3 µM 0.828080947419849 0.205710297033378 no 738 0.203812329354492 1023 1112859
SGTC_2477 5967686 25.23 µM 0.826876741682039 0.206052661493769 no 739 0.204153463680798 1002 776118
SGTC_2932 9016711 44.54 µM 0.82627048137947 0.206225153516469 no 740 0.204325337213322 1036 7117328
SGTC_957 1187-1561 14.1 µM 0.82520670109166 0.206528025030475 no 741 0.204627124823808 1019 1538454
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.822946161471097 0.207172503058429 no 742 0.205269305216743 1095 6708561
SGTC_2708 st078559 56 µM 0.822766966658567 0.20722364219032 no 743 0.205320262543694 918 17250902
SGTC_1629 st005085 44.9 µM 0.822736837667525 0.207232241221671 no 744 0.205328831011975 992 24207091
SGTC_2695 st077686 51.995 µM 0.822398321095148 0.207328870797599 no 745 0.205425117288716 995 2876092
SGTC_1888 azatryptophan 97.5 µM 0.822119474411797 0.207408487607228 no 746 0.20550445144252 911 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1957 st077035 62.4 µM 0.821173747505506 0.20767864783108 no 747 0.205773653899001 1046 705593
SGTC_3248 9135562 49.47 µM 0.818246575196696 0.208516152371355 no 748 0.206608202623504 1022 17650701
SGTC_2264 7948757 110.76 µM 0.813122509956223 0.209987003266388 no 749 0.208073910884819 1046 2971411
SGTC_1438 4092-1045 4 µM 0.810919302345147 0.210621298475835 no 750 0.208706007341868 1035 1351342
SGTC_2571 chrysanthemic acid 100 µM 0.809290028846359 0.211091082430634 no 751 0.209174170157631 965 2743 An insecticide.
SGTC_1857 st056007 79.3 µM 0.808214996759719 0.211401392695386 no 752 0.209483413018225 1017 619834
SGTC_795 0685-0265 78 µM 0.807110038424206 0.211720619488694 no 753 0.209801544571179 1112 302754
SGTC_1287 0971-0001 34.6 µM 0.806743622988919 0.211826540598761 no 754 0.209907102909354 1040 4665869
SGTC_2617 dihydrotanshinone i 20.83 µM 0.806540599677217 0.211885242669595 no 755 0.209965604066056 1068 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1050 3232-1156 69.3 µM 0.80637945323227 0.211931843255638 no 756 0.210012045225675 973 700529
SGTC_2049 5262831 67.185 µM 0.806262479389191 0.211965673693207 no 757 0.210045759963388 1011 763417
SGTC_556 4058-0063 51.5 µM 0.805130747759829 0.212293149061386 no 758 0.210372117032385 1078 6615692
SGTC_937 3122-0005 46.7 µM 0.803241489542419 0.212840478965081 no 759 0.21091758457922 1064 759535
SGTC_2037 5169046 200 µM 0.801678960274399 0.213293775124087 no 760 0.211369344702052 1025 5718022
SGTC_2135 5326629 150.42 µM 0.800976309068692 0.213497800464521 no 761 0.211572680560674 985 5020077
SGTC_2235 salicylic acid 500 µM 0.800685160800766 0.213582373057085 no 762 0.211656967690455 1054 338 A COX inhibitor and kinase inhibitor.
SGTC_1954 st077032 68.9 µM 0.799379675947606 0.213961829515372 no 763 0.212035145806745 994 698907
SGTC_2300 7976697 71.57 µM 0.798212021009813 0.21430155613309 no 764 0.212373731336147 931 2236109
SGTC_1631 benzylvanillin 81.9 µM 0.796071974579334 0.214925011737213 no 765 0.212995101212779 1022 75506
SGTC_1118 chelidonine 707.474 nM 0.795348139035284 0.215136123532263 no 766 0.213205509197222 1114 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1902 st060212 70.5 µM 0.79527459730513 0.215157579236492 no 767 0.213226893441086 1097 688944
SGTC_1006 4099-6547 255 µM 0.794807189682485 0.215293973834919 no 768 0.213362834062462 1037 3146833
SGTC_561 1550-0330 72.9 µM 0.788389275346107 0.217171858821843 no 769 0.215234521019632 1031 6812934
SGTC_1271 0832-2808 169 µM 0.786848684362646 0.217624040815357 no 770 0.215685225097641 1083 3663794
SGTC_1204 4049-0315 18.3 µM 0.784684160962357 0.21826027149526 no 771 0.216319385824299 1018 588402
SGTC_308 4092-1169 104 µM 0.784450180896542 0.218329110714956 no 772 0.216388001743489 1073 2268590 YDL196W YDL196W
SGTC_1145 3546-0597 10.2 µM 0.784033341380401 0.218451779954994 no 773 0.216510273390996 1038 875334
SGTC_309 k408-0051 1.48 µM 0.78387366800168 0.218498779803237 no 774 0.21655712101364 1074 3640463
SGTC_2960 9079389 5.97 µM 0.782013100255172 0.219046866864523 no 775 0.217103437361577 1052 16457355
SGTC_1755 st041960 45.185 µM 0.78129583017524 0.219258371643479 no 776 0.2173142610232 1049 2257073
SGTC_1192 1488-0095 21.4 µM 0.781111871106257 0.219312635420729 no 777 0.217368350249389 1018 915875
SGTC_276 colchicine 750 µM 0.778863582731221 0.219976453094232 no 778 0.21803003910627 1099 2833 A microtubule depolymerizer.
SGTC_1178 0988-0033 191 µM 0.778810103922114 0.219992256987812 no 779 0.218045792464074 1078 5392207
SGTC_3263 9137018 49.47 µM 0.777724390112087 0.220313244635701 no 780 0.218365755166034 1038 43844957
SGTC_1960 st011366 51.8 µM 0.776074484616785 0.220801547350226 no 781 0.218852504046203 1130 3972846
SGTC_1897 st060201 15 µM 0.775876611224186 0.220860151152627 no 782 0.218910921799329 1025 611878
SGTC_1757 st041620 31.8375 µM 0.774253087034588 0.221341323524576 no 783 0.219390570112208 1101 5289815
SGTC_763 3453-1109 128 µM 0.772839858917344 0.221760656950282 no 784 0.219808580453389 1105 1560353
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.772444079913293 0.221878173898902 no 785 0.219925727463485 1077 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_131 0141-0277 33.849 µM 0.772350706701857 0.221905903987279 no 786 0.219953370313034 1048 1547771
SGTC_1258 0671-0043 57.1 µM 0.769047689148835 0.222888110616775 no 787 0.220932500286355 1092 4298767
SGTC_60 0986-0278 202 µM 0.767953033330349 0.223214170147628 no 788 0.221257544207624 952 3110598
SGTC_1978 st071761 42 µM 0.767609240633012 0.223316629921221 no 789 0.221359685429032 1029 5147680
SGTC_1040 k898-0338 155 µM 0.766468600923657 0.223656763888254 no 790 0.221698763922268 1142 20969351
SGTC_319 1348-1596 45.5 µM 0.766342802428742 0.223694294497902 no 791 0.221736178260151 1103 5380505
SGTC_2467 5474540 200 µM 0.764219252712175 0.22432837255885 no 792 0.222368297612772 1104 5413519
SGTC_1995 st072814 61.1 µM 0.762916137503347 0.224717978858841 no 793 0.222756705722539 1043 5769371
SGTC_1806 st050005 60.3 µM 0.76056507997734 0.225421869506782 no 794 0.223458441894241 1087 5194765
SGTC_674 0498-0004 451 µM 0.759918418460803 0.225615694222385 no 795 0.223651675664355 1062 4231473
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.75920966007939 0.22582823959435 no 796 0.223863574161648 942 4000243
SGTC_1316 1272-0050 65.9 µM 0.758957908057059 0.225903763271004 no 797 0.223938868273412 1097 7340392
SGTC_2515 chrysin 20.77 µM 0.75867342002441 0.225989124685377 no 798 0.224023970401957 1100 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2567 aureobasidin a 60 nM 0.756261446796233 0.226713576120641 no 799 0.224746229087893 1092 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.754375291971078 0.227281006608286 no 800 0.225311951791502 1143 551469
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.754280737222134 0.227309473491942 no 801 0.22534033322299 1144 5393153
SGTC_110 0850-0284 111.64 µM 0.752562125182499 0.227827233006466 no 802 0.225856542251484 982 3906265
SGTC_863 0466-0191 129 µM 0.749601954277873 0.228720586138447 no 803 0.22674723673425 1141 765160 YPR165W RHO1
SGTC_946 3434-1334 87.4 µM 0.749458011262553 0.22876407694148 no 804 0.226790598642395 1076 4047976
SGTC_1879 gemcitabine 100 µM 0.748163947634387 0.22915527248701 no 805 0.227180637020708 1121 60750 A nucleoside analog which inhibits DNA replication.
SGTC_617 3770-0098 35 µM 0.745756654464612 0.229883994584712 no 806 0.227907214223112 1078 5962639
SGTC_373 0844-0104 25.9 µM 0.744528797456596 0.230256183489899 no 807 0.228278312994294 1160 5375804
SGTC_1310 1188-0297 994 nM 0.743659020680128 0.230520034645134 no 808 0.228541393523477 1096 1588352
SGTC_2823 7987624 58.44 µM 0.741085265076774 0.231301785340531 no 809 0.229320871612505 1115 2239440
SGTC_3193 9111931 49.47 µM 0.740801126111462 0.231388180053201 no 810 0.22940701614437 1163 17087244
SGTC_2067 5224629 34.075 µM 0.737103292340536 0.232514175438271 no 811 0.230529768583313 1137 2835000
SGTC_2614 arthonioic acid 13.39 µM 0.736075305621062 0.232827739167657 no 812 0.230842435067308 1104 6710684
SGTC_2107 5363541 170.161 µM 0.73537609151829 0.233041152545011 no 813 0.231055239225934 1146 244052
SGTC_600 1495-0418 41.6 µM 0.733252521893361 0.233689971647087 no 814 0.231702213393182 1140 5377768
SGTC_1460 k062-0059 9.15 µM 0.732577717518205 0.233896355653861 no 815 0.231908012813353 1125 1373085
SGTC_2752 diclazuril 33.15 µM 0.731763275995115 0.234145581109631 no 816 0.232156533792828 1223 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3235 9132602 49.47 µM 0.730274585124872 0.234601511923537 no 817 0.232611179971679 1179 4912240
SGTC_216 k038-0035 28.382 µM 0.728850961579461 0.235037973923169 no 818 0.233046417184814 1091 4444231 YPR107C YTH1
SGTC_2472 5377652 49.4 µM 0.726895438341577 0.235638239139486 no 819 0.233645005917064 1155 1610903
SGTC_656 4090-1979 187 µM 0.726334714492864 0.235810514163872 no 820 0.233816801493695 1179 22330961
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.725586738730787 0.236040427930926 no 821 0.23404607658193 1144 97141
SGTC_2240 6690706 185.951 µM 0.724519736846281 0.236368618026859 no 822 0.234373357331184 1075 805876
SGTC_1717 st033143 58.0435 µM 0.724361452119502 0.236417324877151 no 823 0.234421929458691 1151 674616
SGTC_2485 5633444 17.78 µM 0.723297899164624 0.236744741094364 no 824 0.234748441612028 1132 5724239
SGTC_82 0054-0107 293.755 µM 0.723242777343105 0.236761717216598 no 825 0.23476537093403 1156 3104697
SGTC_1984 st072354 53.1 µM 0.722408166421751 0.23701883799171 no 826 0.235021783767247 1123 5762938
SGTC_45 0kpi-0036 14.9 µM 0.72229699702525 0.237053097817322 no 827 0.235055949390585 1139 2795021
SGTC_1249 0481-0015 10.2 µM 0.721177552294092 0.237398236308998 no 828 0.235400140536769 1135 4227577
SGTC_806 3966-4455 5.86 µM 0.72109690346613 0.237423111978127 no 829 0.235424948043249 1074 714982
SGTC_2893 9048488 25.97 µM 0.720407940812761 0.237635676882049 no 830 0.235636931130785 1132 6467338
SGTC_3137 9097352 49.47 µM 0.719135219028773 0.238028622835655 no 831 0.236028804556415 1251 44120435
SGTC_3342 9147791 14.508 µM 0.717482349071264 0.238539468646724 no 832 0.236538261876646 1125 1838168
SGTC_2603 homopterocarpin 100 µM 0.715469802957554 0.239162287491965 no 833 0.237159396798369 1172 101795 A weak amylase inhibitor.
SGTC_1634 st006576 41 µM 0.712443522736698 0.240100495221995 no 834 0.23809508632201 1161 3915356
SGTC_2517 totarol 10 µM 0.71213681251464 0.240195693406835 no 835 0.238190030225077 1136 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2058 5236698 133 µM 0.711751017858005 0.2403154674019 no 836 0.238309484617461 1161 766665
SGTC_614 0462-0418 107 µM 0.711033343586159 0.240538363444149 no 837 0.23853178684571 1057 5188303
SGTC_715 0868-0130 184 µM 0.710540133138377 0.240691610511347 no 838 0.238684626371939 1187 2876258
SGTC_1342 1486-1464 234 µM 0.709892446996536 0.240892935922925 no 839 0.238885417278111 1207 3253938
SGTC_2655 perillic acid 100 µM 0.708672940226059 0.241272253358926 no 840 0.239263730406908 1160 5702197 An apoptosis inducer.
SGTC_2254 7938975 95.19 µM 0.706770299970026 0.241864701453897 no 841 0.239854617086022 1205 2969277
SGTC_1132 3456-3614 2.5 µM 0.705564142498798 0.24224068568727 no 842 0.240229614941097 1236 3125502
SGTC_3322 9139058 2.11 µM 0.705434903851583 0.242280990829422 no 843 0.240269814553406 1189 4908926 YPR165W RHO1
SGTC_1565 sinapyl alcohol 95.1 µM 0.704570481515079 0.24255066820969 no 844 0.24053878688494 1174 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1451 4152-0210 104 µM 0.703423695889446 0.242908686366888 no 845 0.240895871827675 1183 659563
SGTC_827 3253-0474 693 µM 0.702739385287892 0.243122459309679 no 846 0.241109089065308 1188 5402065
SGTC_1015 4130-4525 82 µM 0.700421860785051 0.243847189741599 no 847 0.241831943985361 1189 1363237
SGTC_3046 9092212 49.47 µM 0.700004129066512 0.243977945658864 no 848 0.241962362907677 1205 25236637
SGTC_2161 5662504 8.5105 µM 0.699864354360446 0.244021705556747 no 849 0.242006010118388 1159 2859334
SGTC_2496 diffractaic acid 79.83 µM 0.698818597415861 0.244349239695153 no 850 0.242332702318855 1231 94870 An apoptosis inducer which activates caspases.
SGTC_1583 clindamycin 39.6 µM 0.698298811179524 0.24451212637504 no 851 0.242495171279555 1120 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.698207300472212 0.244540809362834 no 852 0.242523780778306 1209 91467 include heat shock
SGTC_3182 9108849 49.47 µM 0.697551159556622 0.24474652232817 no 853 0.242728967278782 1205 17133045
SGTC_560 2332-1943 155 µM 0.695782083981589 0.245301625906136 no 854 0.243282655429759 1192 21177716
SGTC_2102 5377816 72.7585 µM 0.695563623453025 0.245370221743785 no 855 0.243351076885576 1217 1379702
SGTC_1014 4130-3005 69.3 µM 0.693123512040756 0.246137108331716 no 856 0.244116021797968 1228 743608
SGTC_1251 0490-5699 265 µM 0.692360559173912 0.246377155312901 no 857 0.244355463972715 1249 3883818
SGTC_2345 9052315 157.45 µM 0.69102513235397 0.246797620953642 no 858 0.244774873639233 1198 6469265
SGTC_1142 3253-1408 9.78 µM 0.690884498647968 0.246841922507967 no 859 0.244819064184942 1188 256655
SGTC_1196 1588-0294 184 µM 0.690677798078345 0.246907043759689 no 860 0.244884022346276 1186 6144269
SGTC_2198 6589944 200 µM 0.690056811819927 0.247102741486487 no 861 0.245079230589761 1163 5290268
SGTC_2736 butenafine 14.65 µM 0.687291742127025 0.247975132353669 no 862 0.245949450794451 1200 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_778 3456-2434 196 µM 0.686195704067063 0.248321391179007 no 863 0.246294853211284 1251 5539063
SGTC_3110 9122132 49.47 µM 0.685618595506407 0.248503814053485 no 864 0.246476826069616 1283 918317
SGTC_1723 st034307 2.5525 µM 0.685315411398258 0.248599678553516 no 865 0.24657245440745 1235 867466
SGTC_1680 diphenhydramine 100 µM 0.684725184198441 0.248786360378832 no 866 0.246758676983197 1220 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1733 st037357 54.9 µM 0.684616997789081 0.248820586542567 no 867 0.24679281904018 1189 1272339 YGL099W LSG1
SGTC_3192 9110362 49.47 µM 0.682759499533462 0.249408620826182 no 868 0.247379412740423 1276 16649480
SGTC_2177 5811945 192 µM 0.682302702696339 0.249553343565832 no 869 0.247523782220093 1240 5343475
SGTC_613 3914-0030 117 µM 0.682278667549362 0.249560959635695 no 870 0.247531379713619 1020 1145395
SGTC_429 1112-0049 25.5 µM 0.681400462941143 0.249839322927114 no 871 0.247809065013786 1189 2836170
SGTC_1454 4239-0054 42.6 µM 0.680936488229878 0.249986454863169 no 872 0.247955839347889 1303 1340767
SGTC_3311 9131146 2.8755 µM 0.680853097118337 0.250012904056854 no 873 0.24798222431274 1207 4900406 YPR165W RHO1
SGTC_172 1112-0046 2.638 µM 0.680216170440375 0.250214967328959 no 874 0.248183797455632 1147 2802135 YIL048W NEO1
SGTC_3271 9137798 49.47 µM 0.680193508995507 0.250222158206431 no 875 0.248190970908938 1159 6498326
SGTC_2869 9037858 32.47 µM 0.67906633509705 0.250579968679475 no 876 0.248547915951336 1194 27187042
SGTC_285 1486-1325 46 µM 0.678638140941185 0.250715965791309 no 877 0.248683584939726 1222 22310230
SGTC_2269 7935389 174.42 µM 0.67855883252319 0.25074115892488 no 878 0.248708717338217 1186 97605
SGTC_2851 9015922 71.43 µM 0.676052066317031 0.251538149286491 no 879 0.249503794227902 1216 2996893
SGTC_2331 7980721 200 µM 0.674744539600714 0.251954389175326 no 880 0.249919040853845 1215 2981221
SGTC_2588 indole-3-carbinol 100 µM 0.673573784588869 0.2523273971888 no 881 0.250291162302794 1220 3712 Induces cell cycle arrest.
SGTC_225 nsc-122657 1.016 µM 0.673063184699501 0.252490167820607 no 882 0.250453547107799 1185 275685
SGTC_1922 5578187 25 µM 0.671820921989352 0.252886411156613 no 883 0.250848853853928 1265 1350412
SGTC_2159 5658611 73.75 µM 0.671723417006614 0.252917526074131 no 884 0.250879895385141 1254 793844
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.670877647168229 0.253187505092049 no 885 0.251149238614588 1263 279621
SGTC_2767 sibutramine 71.45 µM 0.670780937634856 0.253218385489868 no 886 0.251180046401552 1294 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1839 st053978 48 µM 0.67048929003028 0.253311523709021 no 887 0.251272965757507 1281 3788398
SGTC_2052 5265182 7.135 µM 0.669697583851894 0.253564447362414 no 888 0.251525296117518 1238 1239884
SGTC_3198 9112019 49.47 µM 0.669412932941583 0.253655416224859 no 889 0.251616051964108 1274 45595555
SGTC_2010 4012422 159 µM 0.669017303988578 0.253781879960253 no 890 0.251742219895758 1215 952393
SGTC_2788 5282734 71.43 µM 0.668923117271185 0.25381199184603 no 891 0.251772261404875 1283 743706
SGTC_1388 3346-4487 254 µM 0.668166469671926 0.254053963275948 no 892 0.252013668090968 1282 3345614
SGTC_341 1486-1430 230 µM 0.666655465955085 0.254537535232341 no 893 0.252496115605257 1215 2054753 YPL210C SRP72
SGTC_1864 st057645 30.4 µM 0.666641614256465 0.254541970470735 no 894 0.252500540556226 1272 688666
SGTC_293 4049-0273 38.5 µM 0.664978783517551 0.255074693824895 no 895 0.253032031673793 1165 1380311
SGTC_1669 st015249 58.4 µM 0.663373752389209 0.255589452439681 no 896 0.253545606008279 1313 722793
SGTC_877 0771-0151 33.1 µM 0.661987725987474 0.256034409004581 no 897 0.253989543944464 1253 6166523
SGTC_2034 5197015 53.07 µM 0.661966741636512 0.256041148722328 no 898 0.253996268269173 1271 780676
SGTC_2110 5483698 200 µM 0.661764143443481 0.256106223621171 no 899 0.254061194596847 1252 2848765 YHR062C RPP1
SGTC_84 0443-0269 128.823 µM 0.661365489723727 0.256234297084223 no 900 0.254188975950608 1209 6150058
SGTC_1746 st038117 42 µM 0.66113760030267 0.256307524962013 no 901 0.254262036984945 1262 2898218
SGTC_391 gliotoxin 8.33 µM 0.660968097691831 0.256361998435727 no 902 0.254316386427743 1294 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1463 k081-0032 34.1 µM 0.66043325112646 0.256533922948456 no 903 0.254487919944683 1114 977755
SGTC_771 0250-0039 27.3 µM 0.658697071802105 0.257092425204701 no 904 0.255045156854915 1243 3005115
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.658362786164285 0.257200032318953 no 905 0.255152521019255 1213 77254
SGTC_2671 danthron 100 µM 0.657445426707921 0.257495452141137 no 906 0.255447275260142 1216 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2473 5854593 8.94 µM 0.656520707727363 0.257793420260998 no 907 0.255744574138665 1222 2872951
SGTC_1503 4585-0012 61.3 µM 0.653804769088817 0.258669598723811 no 908 0.25661879677889 1288 2922052
SGTC_512 prima-1 270 µM 0.65273318743533 0.259015721176705 no 909 0.256964151572971 1283 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2234 tolnaftate 200 µM 0.651560078797446 0.259394911447493 no 910 0.257342504064391 1251 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_638 3970-0837 4.09 µM 0.65123331880695 0.259500582893358 no 911 0.257447942640039 1256 4118451 YLR208W SEC13
SGTC_170 4197-0004 226 µM 0.647926152094716 0.260571342723318 no 912 0.258516357522327 1280 218692
SGTC_2750 bromebric acid 70.15 µM 0.647732871650636 0.260633991320148 no 913 0.258578869747476 1313 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2008 4012253 172 µM 0.646076906026879 0.26117106224397 no 914 0.259114775338217 1287 603940
SGTC_797 k781-0471 270 µM 0.645284084883263 0.261428395085409 no 915 0.259371552196651 1272 23738129
SGTC_389 tpck 16.7 µM 0.645125263958304 0.261479960621397 no 916 0.259423006507176 1254 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1169 aniline yellow 25.8 µM 0.643840055177808 0.261897430663141 no 917 0.259839578349182 1250 6051 A DNA damaging agent.
SGTC_2354 9060492 162 µM 0.643097801028146 0.262138690188522 no 918 0.260080320639583 1282 6471895
SGTC_619 1652-1634 108 µM 0.641611170401281 0.262622241324155 no 919 0.260562839150231 1241 5400454
SGTC_180 1486-1293 102.781 µM 0.640837628292573 0.262874029071335 no 920 0.260814091344984 1330 4140536
SGTC_959 1222-0044 107 µM 0.640434390527116 0.263005331781347 no 921 0.260945115355295 1256 6083612
SGTC_1660 st012960 28.1 µM 0.640134904721509 0.26310287235722 no 922 0.261042449151819 1256 24207266
SGTC_1288 0973-0013 65.5 µM 0.639131189446889 0.263429910616818 no 923 0.261368795714871 1323 4315430
SGTC_781 4335-2806 94.4 µM 0.637128243579683 0.264083145563894 no 924 0.262020656428434 1392 845254
SGTC_185 k048-0037 25.491 µM 0.636272880420403 0.264362362483906 no 925 0.262299288946002 1286 6827589
SGTC_3088 9117578 49.47 µM 0.636037700318733 0.264439158855735 no 926 0.262375924896891 1341 678341
SGTC_3128 9127691 49.47 µM 0.634960227490088 0.264791144974338 no 927 0.262727177480475 1285 41316314
SGTC_2425 5628681 7.85 µM 0.633137371516925 0.265387172872772 no 928 0.263321969745451 1289 5714958
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.632397332279051 0.265629341198335 no 929 0.263563638353932 1280 2374 Ca(2+)-ATPase inhibitor.
SGTC_2927 9011802 47.9 µM 0.631853674338209 0.265807317645675 no 930 0.26374124840047 1276 43912568
SGTC_3217 9129673 49.47 µM 0.631850416099139 0.265808384472463 no 931 0.263742313033162 1278 17248312
SGTC_1564 D-Arginine 115 µM 0.631636730782459 0.265878354985046 no 932 0.263812139697289 1244 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_991 3996-0057 64.7 µM 0.631118538809319 0.26604807389438 no 933 0.263981510156015 1299 715343
SGTC_259 usnic acid 108.925 µM 0.628260485047366 0.26698513223631 no 934 0.264916656458255 1353 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_860 0443-0016 25.1 µM 0.627583743632312 0.267207256489224 no 935 0.265138330407961 1302 5337942
SGTC_235 0330-0087 5 mM 0.625322217496988 0.267950224605688 no 936 0.265879800491114 1293 46494818 YHR062C RPP1
SGTC_1545 lovastatin 49.4 µM 0.623779326845712 0.268457699198561 no 937 0.266386259076981 1343 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2336 9001819 198.65 µM 0.623451961254659 0.2685654356406 no 938 0.266493780572957 1394 2989602
SGTC_2775 cyproheptadine 69.59 µM 0.621514757204852 0.269203416479665 no 939 0.267130493955775 1313 2913 A selective serotonin reuptake inhibitor.
SGTC_2919 7978188 46.38 µM 0.621288880142911 0.269277854199746 no 940 0.267204784392583 1294 2980291
SGTC_211 3455-0679 143.504 µM 0.621075522694634 0.269348175563998 no 941 0.267274966733258 1327 748649
SGTC_3317 9138495 8.753 µM 0.617808380475878 0.270426155261542 no 942 0.268350829260279 1300 17020139
SGTC_1070 indatraline 8.81 µM 0.616885059894788 0.270731191259098 no 943 0.268655270914694 1295 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1701 st028638 40.4 µM 0.615551725810389 0.271171985731076 no 944 0.269095210223003 1332 3490878
SGTC_536 3852-0578 10.6 µM 0.614152548610725 0.271634932111173 no 945 0.269557263161058 1381 2869208
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.613165390250281 0.271961790215506 no 946 0.26988349335511 1220 88881 An O-methylated flavonoid and antioxidant.
SGTC_2905 7799065 20.05 µM 0.612710622067247 0.272112434345552 no 947 0.270033848896146 1287 1296806
SGTC_2968 9090663 33.37 µM 0.612626096144254 0.272140438531853 no 948 0.270061799490821 1325 25236811
SGTC_779 1360-0071 233 µM 0.612593189341831 0.272151341234135 no 949 0.270072681333344 1432 7566
SGTC_657 3534-0529 86.7 µM 0.610472785692214 0.272854332102243 no 950 0.270774332805557 1393 1049549
SGTC_2267 7931562 200 µM 0.610232719268911 0.272933979567443 no 951 0.270853829216309 1248 934880
SGTC_315 k915-0449 187 µM 0.609630610393095 0.273133793508569 no 952 0.271053264825886 1367 20970215 YNL149C PGA2
SGTC_361 000s-0510 1.45 µM 0.606273159732517 0.274249313779735 no 953 0.272166689299451 1334 660
SGTC_1741 st038134 10.228 µM 0.605972586895048 0.27434928937302 no 954 0.272266478414311 1418 1272587
SGTC_999 SEC7.066 22.7 µM 0.605593377040837 0.274475446626681 no 955 0.272392400671396 1362 740511 YDR170C SEC7
SGTC_1016 4226-1401 38 µM 0.605344902653666 0.27455812573392 no 956 0.272474925961741 1329 2901613
SGTC_1613 st002381 52.1 µM 0.601363466054943 0.275884610100516 no 957 0.273798963248705 1329 551167
SGTC_1665 st014639 11.4 µM 0.599767097377313 0.276417350743125 no 958 0.274330732056176 1397 981133 YIL048W NEO1
SGTC_592 k241-0073 46.5 µM 0.599217456339525 0.276600893809451 no 959 0.274513941751023 1376 4230158
SGTC_1874 staurosporine 7.6 µM 0.598713510487659 0.276769230239488 no 960 0.274681973082747 1380 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_231 b-estradiol 524 µM 0.598569304828344 0.276817409461747 no 961 0.274730065098426 1283 450 A steroid.
SGTC_2185 6113692 200 µM 0.59735974001128 0.277221687661431 no 962 0.275133613550978 1345 874150
SGTC_1900 st060200 72.8 µM 0.596620361036121 0.277468955721589 no 963 0.275380437050169 1351 688945
SGTC_2537 larixol 68.93 µM 0.59642264417752 0.27753509577866 no 964 0.275446458422605 1322 6708759
SGTC_1413 3910-0535 34.4 µM 0.591871343451079 0.27905971885253 no 965 0.276968372264416 1400 2876951
SGTC_3356 9151811 4.48 µM 0.588796011555776 0.280092213275545 no 966 0.277999060855109 1340 1859254 YPR165W RHO1
SGTC_620 0109-0052 432 µM 0.587965258729875 0.280371442787044 no 967 0.278277805990454 1365 493037
SGTC_2419 paclitaxel 166.5 µM 0.585295589025069 0.281269673576593 no 968 0.279174490141096 1282 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_209 4077-0173 175.592 µM 0.583780166450696 0.281780166497248 no 969 0.279684111871066 1325 15993494
SGTC_764 1951-2361 146 µM 0.580951814026446 0.28273413241064 no 970 0.2806364649165 1320 5438930
SGTC_926 2268-1401 59.4 µM 0.580570120107222 0.282862991468943 no 971 0.280765107622569 1338 2931578
SGTC_948 3448-0295 75.3 µM 0.580546686684396 0.282870903461712 no 972 0.280773006342925 1371 678569
SGTC_2976 9009005 19.48 µM 0.579752456575229 0.283139127834637 no 973 0.281040781567928 1431 2993148
SGTC_1444 4112-3581 28 µM 0.578325009197787 0.283621506478267 no 974 0.281522356364864 1397 2877249
SGTC_3306 9127676 59.7925 µM 0.577276015473773 0.28397624470215 no 975 0.28187650664591 1366 41905287
SGTC_2993 9054257 71.4286 µM 0.576481473305226 0.28424507626308 no 976 0.282144894450475 1363 6470217 YGL055W OLE1
SGTC_3057 9095946 49.47 µM 0.57594666993262 0.284426094265001 no 977 0.282325614524572 1403 24540043
SGTC_1276 0871-0068 94.2 µM 0.57586286397465 0.284454465545005 no 978 0.282353939173679 1403 3414906
SGTC_858 0438-0351 2.77 µM 0.574034941427252 0.285073618049196 no 979 0.282972078348589 1367 2799119
SGTC_545 4218-0007 221 µM 0.573773555728523 0.285162206888445 no 980 0.283060522872855 1357 2840508
SGTC_1037 k284-1091 78.7 µM 0.573232536719475 0.285345610719928 no 981 0.283243628466648 1348 3334711
SGTC_2519 cryptotanshinone 88.04 µM 0.5717790707654 0.285838609375116 no 982 0.283735829017087 1395 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_889 0919-1524 82.7 µM 0.570793882707439 0.286173003791864 no 983 0.284069685051391 1350 3905452
SGTC_288 1315-0019 35.1 µM 0.569572079773862 0.286587968413163 no 984 0.284483984894342 1403 6811474
SGTC_1622 st003707 19.4 µM 0.568827864524959 0.286840868274895 no 985 0.284736481410968 1413 10140899
SGTC_2625 euphol 100 µM 0.567638591793917 0.287245227359903 no 986 0.285140198426124 1436 6708538 A triterpene alcohol.
SGTC_2180 6301957 200 µM 0.56671856130632 0.287558227600485 no 987 0.285452704055247 1356 845462
SGTC_546 peri-Naphthalide 147 µM 0.565428427413909 0.287997410767662 no 988 0.285891196728799 1385 223824 A penicillin ester.
SGTC_2909 7941780 10.49 µM 0.56536465945436 0.288019126657755 no 989 0.285912878583108 1397 1243215
SGTC_1925 st057770 10.1 µM 0.563788735933888 0.288556045699084 no 990 0.286448959285623 1304 5989122
SGTC_458 nppb 133 µM 0.558381328436241 0.29040193195958 no 991 0.288292010003921 1500 4549 A chloride channel blocker.
SGTC_1972 st070201 17.4 µM 0.558257987458513 0.290444100357712 no 992 0.288334114466845 1421 2829099
SGTC_1231 0242-0792 125 µM 0.557847295414059 0.29058453035806 no 993 0.288474331819369 1377 3707635
SGTC_2933 9026794 32.47 µM 0.556769175304476 0.29095332847929 no 994 0.288842573463 1452 17586027
SGTC_2304 7443016 91.4 µM 0.555522746914438 0.291379973082491 no 995 0.289268577877777 1378 939854
SGTC_2111 5486399 200 µM 0.554830875796679 0.291616922136285 no 996 0.289505173038831 1396 689674
SGTC_2638 epoxomicin 18 µM 0.553539421123856 0.292059454168521 no 997 0.289947047291175 1443 9915668 A protesome inhibitor.
SGTC_1264 0783-0040 158 µM 0.551808140352176 0.292653187681681 no 998 0.290539904733994 1358 2855798
SGTC_5 0352-0601 109.883 µM 0.549258596919765 0.293528559359005 no 999 0.291413998242492 1365 762456
SGTC_2000 st075254 36.4 µM 0.549209387148838 0.293545467184233 no 1000 0.291430881537594 1381 17234175
SGTC_1908 st060353 56.5 µM 0.548337323058306 0.293845171634707 no 1001 0.291730152163244 1526 4227716
SGTC_3260 9137109 49.47 µM 0.547088546521549 0.294274588091876 no 1002 0.292158950303319 1398 17478346
SGTC_1065 prochlorperazine maleate 2.48 µM 0.547010937389534 0.294301285087441 no 1003 0.292185608984818 1428 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_17 0960-0276 49.807 µM 0.545603263953591 0.294785708868474 no 1004 0.292669340126446 1413 6821114
SGTC_765 1319-0117 244 µM 0.544356460812874 0.295215078982955 no 1005 0.293098100401344 1369 3487746 YGL099W LSG1
SGTC_1267 0828-0272 9.49 µM 0.543388444069023 0.295548639924857 no 1006 0.293431190227404 1516 745334
SGTC_294 k038-0071 157 µM 0.542475834363277 0.295863267215832 no 1007 0.293745375261255 1425 24152826
SGTC_1027 k015-0025 8.67 µM 0.541223959626461 0.29629510808099 no 1008 0.294176612450333 1378 3598955
SGTC_56 0957-0365 83.25 µM 0.54089479473964 0.296408703237839 no 1009 0.294290049452944 1380 6752360
SGTC_3161 9100388 49.47 µM 0.540894348182408 0.296408857358779 no 1010 0.294290203359489 1486 25236368
SGTC_1540 guanosine 70.6 µM 0.538921875218987 0.297089977907293 no 1011 0.294970381213011 1391 6802 Guanosine is a purine nucleoside
SGTC_2326 6164455 177.58 µM 0.538086537528118 0.297378646437502 no 1012 0.295258653109359 1424 2888790
SGTC_2688 kanamycin b 96.69 µM 0.537003272490886 0.297753182170219 no 1013 0.295632676789648 1451 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3264 9137442 49.47 µM 0.535634085024442 0.298226882376324 no 1014 0.296105733511782 1499 17015726
SGTC_3324 9138759 60.749 µM 0.535358215141176 0.298322367092183 no 1015 0.296201089079071 1453 45595710
SGTC_1652 st011932 78 µM 0.535333111560156 0.298331056691958 no 1016 0.296209766934981 1469 1551076
SGTC_2678 equilin 100 µM 0.534380352444577 0.298660939213567 no 1017 0.296539204774517 1512 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_14 0354-0009 295 µM 0.533715651326978 0.298891182946126 no 1018 0.296769139464472 1476 1713507
SGTC_2029 5175081 200 µM 0.533127920630657 0.29909483228288 no 1019 0.296972516362704 1415 1380876
SGTC_2528 xanthyletin 44.79 µM 0.532953307298027 0.299155348130851 no 1020 0.29703295141782 1474 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_197 4544-0043 41.561 µM 0.531132118889359 0.29978684945151 no 1021 0.297663614124713 1433 896523
SGTC_1137 ixabepilone 100 µM 0.531112942456036 0.299793502134883 no 1022 0.297670258017066 1406 154225 A novel microtubule stabilizer.
SGTC_1190 1486-1332 13 µM 0.530561506288873 0.299984834822657 no 1023 0.297861338261217 1398 4150046
SGTC_2740 felodipine 17.08 µM 0.528744630748712 0.300615629609188 no 1024 0.298491306088298 1509 3333 L-type calcium channel blocker
SGTC_2384 9036245 200 µM 0.527799169757208 0.300944117668654 no 1025 0.298819366728477 1507 6462766
SGTC_2335 9018011 154.17 µM 0.527630763020337 0.301002645365329 no 1026 0.298877818501955 1546 6458208
SGTC_1690 st023502 41.2 µM 0.527530511228927 0.301037489082657 no 1027 0.298912617052594 1508 24207482
SGTC_193 1273-0060 1.558 µM 0.526851810028925 0.301273427659421 no 1028 0.299148250442551 1369 2847393 YHR072W ERG7
SGTC_901 1112-0062 60.1 µM 0.526159400451849 0.301514217494596 no 1029 0.299388729986864 1451 1908457
SGTC_637 1181-0519 7.26 µM 0.525959343398169 0.301583804728424 no 1030 0.299458227768174 1437 6252091 YGR060W ERG25
SGTC_1447 4239-0816 81.9 µM 0.525946243424171 0.301588361635338 no 1031 0.29946277882075 1393 1341554
SGTC_1705 st027868 56.3335 µM 0.525400666634841 0.301778171392304 no 1032 0.29965234510176 1504 292948
SGTC_3071 9117417 49.47 µM 0.524145101758229 0.302215194533768 no 1033 0.300088810447268 1454 45595590 YGL055W OLE1
SGTC_2195 6536160 144.242 µM 0.523914327646117 0.302295550725886 no 1034 0.300169064499568 1353 3834386
SGTC_2449 5812982 45.77 µM 0.523056532835334 0.302594321281499 no 1035 0.300467456443171 1444 776185
SGTC_2811 7967822 32.47 µM 0.521408396215053 0.30316873952274 no 1036 0.301041151857641 1519 2232244
SGTC_2227 7312221 64.1025 µM 0.521124879735233 0.303267601486924 no 1037 0.301139890093069 1461 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_114 0364-0001 490.298 µM 0.51923184187415 0.303928071257067 no 1038 0.301799538348039 1402 4003655
SGTC_2512 diallyl trisulfide 49.23 µM 0.518066111372606 0.304335106609737 no 1039 0.302206071814685 1420 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_987 1497-1013 404 µM 0.516975205154105 0.30471623543782 no 1040 0.302586733736754 1454 1676435
SGTC_2492 derrusnin 100 µM 0.516789874250449 0.304781005395793 no 1041 0.302651424639282 1395 1715307 Part of coumarin class of compounds.
SGTC_342 k048-0088 23.3 µM 0.516155689551294 0.305002688306543 no 1042 0.30287283761428 1413 6820570
SGTC_1872 amphotericin b 148 nM 0.516018409500567 0.30505068476537 no 1043 0.30292077576005 1498 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_530 4358-1714 28 µM 0.514005791691759 0.305754729748588 no 1044 0.303623970704519 1502 1564641
SGTC_2231 micatex 6.853 µM 0.5138378639082 0.305813506010936 no 1045 0.3036826764541 1484 20737 An antifungal of unknown mechanism.
SGTC_1127 asiatic acid 681.4 nM 0.511283630801728 0.306708126964391 no 1046 0.304576232724454 1436 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3277 9138724 49.47 µM 0.51003687020117 0.307145224268549 no 1047 0.305012815686919 1441 15943418
SGTC_1697 st025554 27.742 µM 0.50947363277192 0.307342777594535 no 1048 0.305210137804816 1449 1269519
SGTC_2407 paclitaxel 400 µM 0.507935520441412 0.307882549177225 no 1049 0.305749281647441 1610 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3218 9131285 49.47 µM 0.506556557629555 0.308366823941663 no 1050 0.306232998173828 1615 17156417
SGTC_1417 3966-0327 90.4 µM 0.505597047897552 0.308703988869551 no 1051 0.306569777208319 1512 651118
SGTC_144 4161-2749 112.381 µM 0.50466407166978 0.309031984817518 no 1052 0.306897399933987 1386 797501 YMR168C CEP3
SGTC_2844 9010103 25.97 µM 0.503257012456712 0.309526936801242 no 1053 0.307391792778087 1467 2480525
SGTC_2309 7664088 163.95 µM 0.503027360630732 0.30960775275392 no 1054 0.307472517897597 1518 704922
SGTC_2430 5571206 200 µM 0.50009910928809 0.310639029204284 no 1055 0.308502646646687 1540 1731771
SGTC_521 r062-0005 13.8 µM 0.496734255915825 0.311825908461888 no 1056 0.309688231150647 1476 2832033
SGTC_2237 6667747 47.222 µM 0.496658794089017 0.311852548469466 no 1057 0.309714842416936 1501 729940 YDL015C TSC13
SGTC_3318 9139014 38.6185 µM 0.496384664068253 0.311949331851921 no 1058 0.309811521500129 1483 16643984
SGTC_1289 0976-0073 69.1 µM 0.495531779804208 0.312250531197409 no 1059 0.310112397440695 1521 3391136
SGTC_2100 5377183 190 µM 0.495432015468606 0.312285771558429 no 1060 0.310147600080414 1586 2844202
SGTC_2887 9044784 58.44 µM 0.494840109670451 0.312494889342179 no 1061 0.310356494528859 1454 6465546
SGTC_1591 genipin 88.4 µM 0.493529027478939 0.312958304031698 no 1062 0.310819417371812 1537 442424 A DNA cross-linking agent.
SGTC_156 3474-0145 5.642 µM 0.491548820053542 0.313658787918249 no 1063 0.311519165830574 1562 2265471
SGTC_2771 fluoxetine 41.05 µM 0.491392933475357 0.313713960235429 no 1064 0.311574280633436 1533 3386 A selective serotonin reuptake inhibitor.
SGTC_809 3998-0021 90 µM 0.487346237590783 0.31514764620011 no 1065 0.313006493016064 1491 715485
SGTC_908 3448-7491 47.7 µM 0.487235062253719 0.31518707347536 no 1066 0.31304588033641 1488 1203031
SGTC_1125 tnp00248 1.32998 µM 0.485841777959851 0.315681366888926 no 1067 0.31353967542385 1644 24207736
SGTC_839 0122-0028 230 µM 0.485456771655313 0.315818013218523 no 1068 0.313676184835572 1509 759448
SGTC_1042 0350-0096 82 µM 0.48465572734375 0.316102400307768 no 1069 0.313960288142726 1468 3122515
SGTC_1167 k781-0610 148 µM 0.48404646834328 0.316318772579107 no 1070 0.314176445560317 1511 4525169
SGTC_1785 bathophenanthroline 24 µM 0.483887115226563 0.316375375633357 no 1071 0.314232992559586 1457 72812 An iron chelator.
SGTC_2806 7952793 58.44 µM 0.482082882580595 0.317016548278338 no 1072 0.314873534603621 1544 2972490
SGTC_2462 5162487 171.77 µM 0.47920835011318 0.318039210162452 no 1073 0.315895207255293 1515 2259986
SGTC_1725 st036284 20.55 µM 0.478583365120028 0.318261742880191 no 1074 0.316117527407824 1673 707914
SGTC_2253 7938677 135.83 µM 0.478146874110631 0.318417199176236 no 1075 0.316272835781007 1618 2301972
SGTC_1345 1488-0192 31.4 µM 0.478076565793164 0.318442242478167 no 1076 0.316297855297098 1566 658348
SGTC_2713 st079149 53.4 µM 0.477938921696497 0.318491272687708 no 1077 0.31634683897354 1542 3103253
SGTC_2314 7727897 200 µM 0.477589357244602 0.318615805342429 no 1078 0.316471253647692 1479 900724
SGTC_418 lividomycin a 100 µM 0.472511528348791 0.320427091249733 no 1079 0.31828085751018 1560 72394 An antibiotic.
SGTC_1020 4335-0961 93.3 µM 0.471706963967115 0.320714477649759 no 1080 0.318567982856122 1454 669075
SGTC_3109 9122853 49.47 µM 0.471448143822254 0.320806949778643 no 1081 0.318660371324435 1589 1234709
SGTC_733 4069-0007 56.1 µM 0.47080102538676 0.321038203066964 no 1082 0.318891416116593 1553 5717425 YNL287W SEC21
SGTC_2400 5203494 178.7 µM 0.47060684896609 0.321107607212431 no 1083 0.318960757888794 1487 6777674
SGTC_299 1273-0059 1.44 µM 0.469274273063567 0.321584076040773 no 1084 0.319436801019386 1529 2848077
SGTC_1677 st019204 53.9 µM 0.468030626485857 0.322029012713547 no 1085 0.319881344108471 1472 3945625
SGTC_357 1325-0123 420 µM 0.466540287490377 0.322562544155204 no 1086 0.320414408609606 1578 1098503
SGTC_3344 9148862 3.898 µM 0.46256658876386 0.323986886408754 no 1087 0.321837531011969 1615 4905352
SGTC_3089 9117425 49.47 µM 0.461293230076357 0.324443859230138 no 1088 0.322294120685316 1471 9401657
SGTC_1325 1431-0015 227 µM 0.461056753406785 0.324528753233434 no 1089 0.322378943948297 1460 1103340
SGTC_2247 cerulenin 830 nM 0.459145776371895 0.325215119194041 no 1090 0.323064743020193 1611 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2272 7805186 180 µM 0.458914546246135 0.325298210451084 no 1091 0.323147766258697 1546 2956062 YPR165W RHO1
SGTC_3262 9137218 49.47 µM 0.458451049756289 0.325464791483998 no 1092 0.323314211324017 1487 17650664
SGTC_712 r015-0009 80.6 µM 0.456944803616006 0.326006378284859 no 1093 0.323855359714665 1603 6813872 YLR060W FRS1
SGTC_1335 1486-0900 202 µM 0.456817981616866 0.326051995260543 no 1094 0.323900940018262 1520 X1335
SGTC_2677 mitomycin C 100 µM 0.45375867483175 0.327153193753071 no 1095 0.325001265222402 1550 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1062 mesoridazine 14.2 µM 0.452808315574669 0.327495582991937 no 1096 0.325343387616952 1547 4078 A neuroleptic.
SGTC_1013 4112-3890 241 µM 0.452329095616557 0.327668288300744 no 1097 0.325515959167678 1512 705171
SGTC_427 1354-0053 47.3 µM 0.452238505555739 0.327700940052143 no 1098 0.3255485856941 1624 6813657
SGTC_2441 5730946 39.09 µM 0.450422885277713 0.328355629138057 no 1099 0.326202773253492 1635 1774275
SGTC_3313 9133968 57.047 µM 0.449827600906652 0.328570395864867 no 1100 0.326417377220091 1530 1494643
SGTC_2163 5671233 125 µM 0.449363274764356 0.328737954802334 no 1101 0.326584809777686 1650 701023
SGTC_835 0312-0010 67.2 µM 0.448901891918587 0.328904485716384 no 1102 0.326751215611608 1544 1626196
SGTC_3206 9114350 49.47 µM 0.448892662322738 0.328907817381181 no 1103 0.326754544779349 1519 17087243
SGTC_1775 st081588 35.1725 µM 0.447671285997303 0.329348825054984 no 1104 0.327195223766642 1542 1426443 YGL099W LSG1
SGTC_2023 5144124 124 µM 0.447536659706306 0.329397449700254 no 1105 0.327243812395671 1530 2830192
SGTC_1485 3909-9022 254 µM 0.444493438347806 0.330497376056174 no 1106 0.328342935910489 1556 714516
SGTC_1193 1488-0126 41.5 µM 0.444311854676601 0.330563053160427 no 1107 0.328408565795436 1553 1384710
SGTC_1274 0865-0114 173 µM 0.443559156314861 0.330835352696447 no 1108 0.328680670421463 1581 870624
SGTC_2785 7756463 72.73 µM 0.442500405870705 0.331218522523746 no 1109 0.3290635683319 1498 2201551
SGTC_3154 9100113 49.47 µM 0.441872142239056 0.331445979512293 no 1110 0.329290865205688 1524 25237525
SGTC_2176 5809774 33.9695 µM 0.439513441266957 0.332300479579875 no 1111 0.330144772405515 1651 2870539
SGTC_746 1095-0025 46.6 µM 0.43812139553181 0.33280519366192 no 1112 0.330649142712477 1663 6749286
SGTC_3087 9117406 49.47 µM 0.438061821012326 0.33282680036825 no 1113 0.330670734807904 1555 42546093
SGTC_3308 9128332 17.569 µM 0.437003906620971 0.333210581065765 no 1114 0.331054257434467 1694 17332805 YDL196W YDL196W
SGTC_244 nsc-207895 1.295 µM 0.436902848920305 0.333247251020159 no 1115 0.331090902873965 1492 42640
SGTC_2337 9009472 200 µM 0.434996732668624 0.333939205572245 no 1116 0.331782399525641 1669 5742383
SGTC_1681 tripelennamine 100 µM 0.434354773603647 0.334172375583779 no 1117 0.33201541724225 1523 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1534 6-azauridine 81.6 µM 0.433694602300939 0.334412227341407 no 1118 0.332255113394291 1577 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2724 maprotiline 69.64 µM 0.431104035049945 0.335354078072455 no 1119 0.33319636341451 1637 4011 A tricyclic antidepressant.
SGTC_840 0245-0196 390 µM 0.430598352739812 0.335538049650089 no 1120 0.333380219573819 1651 3827528
SGTC_2069 5228469 200 µM 0.429184241207526 0.336052724816778 no 1121 0.333894575174185 1549 2835210
SGTC_1029 k015-0030 64.7 µM 0.428817877379506 0.336186115530879 no 1122 0.334027883863747 1629 2208316
SGTC_3123 9126162 49.47 µM 0.428764568434566 0.336205526694525 no 1123 0.334047283118487 1606 25239884
SGTC_90 0870-0863 4.608 µM 0.428009728865449 0.336480430128172 no 1124 0.334322018643664 1561 1738164
SGTC_1172 0370-0043 85 µM 0.427591963375165 0.336632612856557 no 1125 0.334474109020096 1631 376585
SGTC_2936 9038235 15.59 µM 0.427470360350641 0.336676915178099 no 1126 0.334518384537116 1567 4749415
SGTC_1202 1988-0068 29.6 µM 0.427086484131204 0.336816783540569 no 1127 0.334658168511688 1525 2850480
SGTC_499 genistein 192 µM 0.427081913036886 0.336818449191269 no 1128 0.334659833159611 1658 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.426487022701002 0.337035247234122 no 1129 0.334876501119484 1618 66535 A nucleotide analog.
SGTC_2149 5554786 194.827 µM 0.42573779514934 0.3373083679779 no 1130 0.335149459218461 1602 745063 YPR165W RHO1
SGTC_2489 cantharidin 73.42 µM 0.424371751873677 0.337806561161592 no 1131 0.335647359262974 1543 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_307 1501-1223 22.3 µM 0.420862063736126 0.339087839037846 no 1132 0.336927904179871 1598 2830329
SGTC_3127 9126946 49.47 µM 0.419426349900194 0.339612511358831 no 1133 0.337452285049095 1532 27243249
SGTC_446 go6976 132 µM 0.418722391541927 0.339869882063209 no 1134 0.337709514628161 1688 3501 A protein kinase C inhibitor.
SGTC_685 1278-0033 54.9 µM 0.414604511217571 0.341376892090375 no 1135 0.339215722597433 1679 3590572
SGTC_1996 st072960 66.8 µM 0.414464903990691 0.341428028310452 no 1136 0.339266832328539 1687 1719405
SGTC_3155 9099265 49.47 µM 0.414061404253483 0.341575841116146 no 1137 0.339414568833801 1632 25236499
SGTC_697 0508-1955 564 µM 0.413877428621734 0.341643244404728 no 1138 0.339481937461116 1712 6243113
SGTC_1244 0416-0015 52.5 µM 0.412653239125295 0.342091880121424 no 1139 0.33993034457915 1597 96201
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.412377698141682 0.342192889968461 no 1140 0.340031303462318 1681 688662
SGTC_3098 9119039 49.47 µM 0.410711322763935 0.342804002575197 no 1141 0.340642111689499 1614 17161528
SGTC_1780 st038448 24.544 µM 0.410477489570603 0.342889789573736 no 1142 0.340727856502452 1718 728868 YDL195W SEC31
SGTC_1360 1598-0022 39.8 µM 0.410474354762031 0.342890939704238 no 1143 0.340729006068286 1703 761525
SGTC_3179 9107801 49.47 µM 0.409052548833703 0.343412736281033 no 1144 0.34125054893846 1586 4818259
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.408619133490426 0.343571857252632 no 1145 0.341409593524517 1725 688664
SGTC_952 1185-0122 232 µM 0.408530276949179 0.343604482825337 no 1146 0.341442203492069 1568 678600
SGTC_166 k072-0058 166.424 µM 0.407764285136877 0.343885781332173 no 1147 0.341723368250288 1652 5846229
SGTC_562 3772-2733 112 µM 0.406375440537601 0.344396033136568 no 1148 0.34223338109956 1678 2876874 YIL048W NEO1
SGTC_2576 guaiol 23.12 µM 0.40611509693292 0.344491713119193 no 1149 0.342329016798501 1781 227829
SGTC_3203 9113543 49.47 µM 0.406052694740806 0.344514648292226 no 1150 0.342351941380997 1676 17018012
SGTC_1917 st066507 28.5 µM 0.40590330429034 0.344569557272607 no 1151 0.342406825045236 1591 3156428
SGTC_2961 9083290 32.55 µM 0.405624968615658 0.34467186925411 no 1152 0.342509090000406 1631 17741490
SGTC_583 1488-1091 88.9 µM 0.404827800532402 0.344964959027485 no 1153 0.34280204610519 1710 4303273
SGTC_2979 9012552 45.46 µM 0.404596709822361 0.345049940098323 no 1154 0.342886988708888 1649 17100905
SGTC_2786 7743617 45.45 µM 0.402283103229884 0.345901173703251 no 1155 0.343737844182052 1522 583674
SGTC_2447 5741742 33.78 µM 0.401598317523216 0.346153273142696 no 1156 0.343989834139526 1698 1776504
SGTC_29 0299-0004 12.984 µM 0.400129246050436 0.346694332275001 no 1157 0.344530662159016 1587 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2025 5147754 141 µM 0.394224452681212 0.348872214219867 no 1158 0.346707666932385 1716 315777 YLR208W SEC13
SGTC_728 3030-5151 22.5 µM 0.394116735050254 0.348911990569604 no 1159 0.346747428050896 1664 3125388
SGTC_3028 9087778 49.47 µM 0.392980613979806 0.349331621338876 no 1160 0.347166899855374 1563 17217395
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.392880124658881 0.349368746339225 no 1161 0.347204010943314 1666 1241132 A phosphatase inhibitor.
SGTC_535 2293-4129 48.2 µM 0.392493842237291 0.349511468798884 no 1162 0.347346680147361 1742 396118 YIL048W NEO1
SGTC_94 0334-0113 514.748 µM 0.390690708130223 0.350177966502321 no 1163 0.34801293395967 1579 6795178
SGTC_3024 9090631 49.47 µM 0.390500222981039 0.350248403081774 no 1164 0.348083345226542 1757 25236383
SGTC_62 0180-0423 3.232 µM 0.390061613022818 0.350410609508567 no 1165 0.348245493697484 1697 30102 YGL099W LSG1
SGTC_2342 7990637 118.86 µM 0.388579080625226 0.350959080420273 no 1166 0.348793772108292 1676 2033102 YER133W GLC7
SGTC_920 mycophenolic acid 780.421 nM 0.386618118362586 0.351685026173746 no 1167 0.34951947128772 1607 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3242 9133940 49.47 µM 0.384633479718103 0.352420287946811 no 1168 0.350254492847715 1689 17248444
SGTC_2189 6047310 154.431 µM 0.382762313690368 0.353114016306809 no 1169 0.35094800333659 1642 711535
SGTC_2104 5389443 200 µM 0.382746158095422 0.353120008068123 no 1170 0.350953993253198 1728 2244536
SGTC_1684 st024538 14.6195 µM 0.38269533656016 0.353138856915602 no 1171 0.350972836301748 1627 6732859
SGTC_2975 9084847 53.72 µM 0.381154948967395 0.353710331385738 no 1172 0.351544137933747 1635 27211724
SGTC_2072 5231554 129 µM 0.380776639383348 0.353850732448998 no 1173 0.35168449741563 1811 789545
SGTC_1477 0139-0234 16 µM 0.380230935787522 0.354053293035473 no 1174 0.351886998623952 1693 620880
SGTC_1290 0986-0249 10.2 µM 0.377203733294448 0.355177713934016 no 1175 0.353011103050594 1692 53329
SGTC_18 0111-0177 500 nM 0.377039720760471 0.355238670707623 no 1176 0.353072043303214 1689 721752
SGTC_1713 st033146 12.748 µM 0.374950630421032 0.356015424039603 no 1177 0.353848591826631 1783 674619
SGTC_2742 clothiapine 36.27 µM 0.374576945873272 0.356154428381733 no 1178 0.353987560633879 1756 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2533 agelasine 13.65 µM 0.37435499048547 0.356237001090102 no 1179 0.35407011239385 1835 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1382 3002-2117 298 µM 0.373262128665737 0.356643670056013 no 1180 0.354476679932378 1783 1497314
SGTC_1865 st057639 52.2 µM 0.3722651242796 0.35701481136248 no 1181 0.354847731199662 1664 688818
SGTC_2598 perillyl alcohol 100 µM 0.369113475073504 0.358188921846538 no 1182 0.356021572700712 1728 10819 An apoptosis inducer.
SGTC_1610 st001799 48.1 µM 0.368794091700182 0.35830797952001 no 1183 0.356140604442402 1607 621897
SGTC_2640 pentamidine 10.38 µM 0.36819466528804 0.358531467015605 no 1184 0.356364043927807 1821 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2220 6782180 200 µM 0.367265872545073 0.358877849689432 no 1185 0.356710353910386 1753 833803
SGTC_1815 st051655 58.2 µM 0.367125508662199 0.358930206904431 no 1186 0.356762700319571 1775 5984156
SGTC_3031 9088762 49.47 µM 0.366264392842412 0.359251470197819 no 1187 0.357083898353082 1619 205253
SGTC_1028 k015-0029 4.8 µM 0.366110249399291 0.359308988222238 no 1188 0.357141404883083 1641 4588309
SGTC_1672 st016598 6.51 µM 0.365242293920568 0.35963292191302 no 1189 0.357465274913079 1631 4665860 YNL267W PIK1
SGTC_2286 7945697 125 µM 0.364747823588295 0.359817510600549 no 1190 0.357649828140128 1599 1245733
SGTC_302 1094-0063 18.9 µM 0.36293331673075 0.360495156589267 no 1191 0.358327349021487 1677 5440289
SGTC_3290 9121031 71.43 µM 0.36287612162822 0.360516523818342 no 1192 0.358348712435293 1642 17014854
SGTC_482 fipronil 114 µM 0.361957027375737 0.360859943285849 no 1193 0.35869207166856 1722 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_680 0417-1641 114 µM 0.360615365074718 0.36136145666394 no 1194 0.359193500753285 1664 2835990
SGTC_554 4483-2211 187 µM 0.360237263762261 0.361502834021139 no 1195 0.359334855134566 1699 747107
SGTC_1104 tacrolimus 29.8 µM 0.359311565702708 0.36184904523878 no 1196 0.359681011547302 1709 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2728 chlorpromazine 9.18 µM 0.357685477328491 0.362457476218419 no 1197 0.360289351230322 1717 2726 A thorazine and dopamine antagonist.
SGTC_1802 st050112 57.9 µM 0.35556490633124 0.363251448995249 no 1198 0.361083214474023 1694 4662563
SGTC_2955 9076254 12.21 µM 0.354929313445632 0.363489538937974 no 1199 0.361321273687525 1829 16459619
SGTC_691 1548-0686 185 µM 0.354172550255672 0.363773087449971 no 1200 0.361604786875861 1647 46495133
SGTC_2717 st081029 62.2815 µM 0.353599807500147 0.363987735715447 no 1201 0.361819409320657 1799 5292846
SGTC_631 k072-0230 41.5 µM 0.352446693979414 0.364420020426032 no 1202 0.36225164443345 1739 5773147
SGTC_260 nsc-65238 3.989 µM 0.352310194711812 0.364471203353036 no 1203 0.362302821700533 1758 3246252
SGTC_2824 7998404 51.95 µM 0.351759309866856 0.364677792369601 no 1204 0.362509388329088 1723 837851
SGTC_846 0335-0850 148 µM 0.350076609396858 0.365309070188772 no 1205 0.363140602273151 1716 6819598
SGTC_2073 5212005 126 µM 0.349212652778687 0.365633332020937 no 1206 0.363464833950097 1815 691789
SGTC_1590 st077108 57.8 µM 0.348391944076709 0.365941450920412 no 1207 0.363772925863362 1832 5489485
SGTC_616 4092-0450 108 µM 0.348202653768099 0.366012528515282 no 1208 0.36384399746355 1742 787165
SGTC_3232 9132874 49.47 µM 0.347818157298494 0.366156919233814 no 1209 0.363988376270198 1652 3784940
SGTC_3283 9109332 35.8195 µM 0.347177400952104 0.36639758583491 no 1210 0.364229023808982 1670 17027281
SGTC_1472 k841-0093 193 µM 0.346814589701627 0.366533880209829 no 1211 0.364365307827486 1791 X1472
SGTC_2171 5739187 198.077 µM 0.346464046561058 0.366665581912266 no 1212 0.364496999823918 1649 2262761
SGTC_2520 obtusaquinone 4.71 µM 0.346342854556946 0.366711118315447 no 1213 0.364542532940116 1800 5967872
SGTC_2675 theaflavin digallate 100 µM 0.346152330550539 0.366782709157295 no 1214 0.364614118685856 1720 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1005 4092-0690 4.4 µM 0.34595903018687 0.366855347972329 no 1215 0.364686752419601 1675 1529343
SGTC_1479 0549-0158 134 µM 0.342555030251542 0.368135289256752 no 1216 0.365966618927128 1693 5440202
SGTC_2948 9070189 9.45 µM 0.342206209255227 0.368266532774489 no 1217 0.366097856354313 1837 6473636 YDL196W YDL196W
SGTC_3018 9082602 49.47 µM 0.341748211684013 0.368438877201958 no 1218 0.3662701932288 1721 17332089
SGTC_2346 9031566 143.75 µM 0.34087793830152 0.368766433880176 no 1219 0.366597736943567 1808 4771086
SGTC_738 1315-0003 72.4 µM 0.340789863928029 0.368799588952485 no 1220 0.366630890805324 1803 6251474
SGTC_932 2857-0803 154 µM 0.340146007525369 0.369041994500175 no 1221 0.366873288069542 1824 674898
SGTC_1418 3966-3099 2.4 µM 0.339605868400855 0.369245391709278 no 1222 0.367076679097804 1779 740335
SGTC_2066 5222451 176 µM 0.339605022259525 0.369245710364784 no 1223 0.367076997744177 1697 2281147
SGTC_2178 5812956 200 µM 0.337919323864509 0.369880719868058 no 1224 0.367711992469134 1729 5403383
SGTC_1935 st074532 41.6 µM 0.334701794138782 0.371093760606178 no 1225 0.368925023955906 1892 2829742
SGTC_1878 temozolomide 1 mM 0.33274621884804 0.371831659126419 no 1226 0.369662929010814 1869 5394 DNA alkylating agent.
SGTC_571 k831-0106 44.2 µM 0.331849211549654 0.372170285249174 no 1227 0.370001561206424 1840 4783639
SGTC_1819 st053448 58.6 µM 0.331608496914993 0.372261173436427 no 1228 0.37009245135253 1746 2857616
SGTC_1223 0764-0573 147 µM 0.328396831829942 0.373474501682807 no 1229 0.371305819062909 1732 1609797
SGTC_2928 9011484 9.79 µM 0.327894038998102 0.373664564692377 no 1230 0.371495890495809 1723 2994751
SGTC_2630 antimycin a 100 µM 0.327468882020243 0.373825304199904 no 1231 0.371656637600337 1679 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1969 st069479 40.1 µM 0.326227644673136 0.374294705470811 no 1232 0.372126063537306 1821 3895485
SGTC_484 loperamide 105 µM 0.325437037511533 0.374593788226132 no 1233 0.372425163935077 1751 3955 An opioid-receptor agonist.
SGTC_2673 kobusone 100 µM 0.325317991167081 0.374638829406948 no 1234 0.372470207902622 1788 6710676 An epoxy ketone and protein crosslinker.
SGTC_1794 st048918 76.9 µM 0.325212374832996 0.374678790775627 no 1235 0.37251017177218 1860 672303
SGTC_1998 st075797 76.8 µM 0.325008301651078 0.374756008436778 no 1236 0.372587394341548 1855 24208315
SGTC_220 paclitaxel 373.376 µM 0.324814082927254 0.374829502010313 no 1237 0.372660892679299 1792 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1003 4049-0218 100 µM 0.324261101569057 0.375038778487006 no 1238 0.372870183217519 1809 295161
SGTC_1847 st056231 15 µM 0.323017635398526 0.375509504104517 no 1239 0.373340943140561 1699 5393180
SGTC_1764 st044502 93.5 µM 0.32215939178563 0.375834508345349 no 1240 0.373665973228087 1731 8407
SGTC_174 3553-0389 74.3 µM 0.321657198964675 0.376024722260467 no 1241 0.37385620308867 1783 738071
SGTC_1638 st008370 60.6 µM 0.321327337029386 0.376149679370286 no 1242 0.373981171002194 1711 24207134
SGTC_487 nimodipine 119 µM 0.321197063216564 0.376199032804073 no 1243 0.374030528774817 1849 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3063 1327-0034 4 µM 0.318714688473838 0.377139851200719 no 1244 0.374971437647179 1812 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_867 0518-0118 155 µM 0.3186712063205 0.377156337427974 no 1245 0.374987925591311 1846 6848158
SGTC_729 4092-0585 94.1 µM 0.31669341948652 0.377906450173156 no 1246 0.37573812123608 1701 2169061
SGTC_99 0109-0120 622.8 µM 0.316586734856855 0.37794692543677 no 1247 0.375778601238841 1840 759414
SGTC_77 0828-0286 12.516 µM 0.315474220195439 0.378369084031323 no 1248 0.376200810884682 1721 745345
SGTC_1829 berberine 14.4 µM 0.310033825863538 0.380435597385507 no 1249 0.378267616760626 1885 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2682 pyrogallin 40.03 µM 0.308660144844436 0.380957927590723 no 1250 0.378790032082812 1819 822798 An ATP competetive kinase inhibitor.
SGTC_124 0136-0217 7.121 µM 0.30809055552104 0.381174572652501 no 1251 0.379006713768883 1935 3976905
SGTC_1523 st012844 44.7 µM 0.308039152501063 0.38119412578356 no 1252 0.379026270243513 1768 4274103
SGTC_1668 st014914 51.6 µM 0.307830166602946 0.381273624793145 no 1253 0.379105782912273 1780 2839556
SGTC_2791 5663188 71.43 µM 0.305579751616888 0.38213000780417 no 1254 0.37996231966405 1869 54690634
SGTC_3291 9121177 71.43 µM 0.305456213440665 0.382177036319859 no 1255 0.380009356972089 1741 17015612
SGTC_1552 6-methylflavone 10.6 µM 0.304075274879329 0.382702850210947 no 1256 0.380535271644169 1887 689013
SGTC_1046 2001-0062 216 µM 0.303716886299429 0.382839347639509 no 1257 0.380671795977448 1736 739778
SGTC_3120 9124077 49.47 µM 0.30166995976506 0.383619227390801 no 1258 0.381451835313806 1811 18774327 YGL155W CDC43
SGTC_2 0422-0095 29 µM 0.301432171268659 0.383709855534971 no 1259 0.381542482649903 1764 6790840
SGTC_2112 5488546 200 µM 0.29957562742382 0.384417657008062 no 1260 0.382250438639136 1761 600757
SGTC_2834 9001755 58.44 µM 0.299452474199131 0.384464622446836 no 1261 0.382297414620777 1762 2989575
SGTC_190 3970-0790 3.722 µM 0.299438719106778 0.384469868163444 no 1262 0.382302661517191 1865 2832352
SGTC_3172 9105863 49.47 µM 0.299315765838073 0.384516759228374 no 1263 0.382349563148311 1826 2348785
SGTC_1619 st003326 88.7 µM 0.299266635411727 0.384535496722188 no 1264 0.382368304874392 1876 2849032
SGTC_2118 5526350 200 µM 0.299256658829045 0.384539301651011 no 1265 0.382372110663341 1816 743594
SGTC_1088 bifonazole 369 nM 0.296007318825576 0.385779144178153 no 1266 0.383612246061001 1796 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2818 7996756 12.99 µM 0.294812594311968 0.386235306527203 no 1267 0.384068522474826 1765 2241621
SGTC_1738 st035555 74 µM 0.294234378305751 0.386456133924507 no 1268 0.384289406308562 1805 5331140
SGTC_698 k064-0052 127 µM 0.293475790684298 0.386745903100239 no 1269 0.384579250744441 1837 5088751
SGTC_3274 9138298 49.47 µM 0.292477578151472 0.387127301624315 no 1270 0.384960750409366 1843 17015756
SGTC_177 1327-0068 8.361 µM 0.292111206063563 0.387267312978381 no 1271 0.385100799485706 1785 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2013 4024628 200 µM 0.291901448890145 0.387347479579787 no 1272 0.385180987829259 1844 5230760
SGTC_3338 9144300 39.5675 µM 0.291832050792166 0.387374003733678 no 1273 0.385207519199811 1850 4901274
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.29149909977089 0.387501265887719 no 1274 0.385334816138157 1930 756377
SGTC_1480 1070-0044 41.2 µM 0.291231043277243 0.387603732525585 no 1275 0.385437310974185 1880 3124987
SGTC_392 N-ethylmaleimide 8.33 µM 0.290600276301693 0.387844878884385 no 1276 0.385678524367584 1754 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1927 st060202 13.8 µM 0.289258670750009 0.388357927257714 no 1277 0.386191718498744 1936 688887
SGTC_2370 9071495 200 µM 0.288961602936371 0.388471556447884 no 1278 0.386305380548443 1768 21791103
SGTC_802 4112-3352 742 µM 0.28834823429583 0.388706201694966 no 1279 0.38654009431281 1905 704594
SGTC_1784 st039334 36.3 µM 0.287220744942669 0.389137630601416 no 1280 0.386971651524837 1906 3496984
SGTC_960 1222-0186 7.7 µM 0.285693900182438 0.389722088967279 no 1281 0.387556288509521 1862 3126296
SGTC_383 2324-0395 7.37 µM 0.285001984941606 0.389987028271395 no 1282 0.387821310601396 1872 3146421
SGTC_224 benfluorex 43.875 µM 0.28458117533067 0.390148184292339 no 1283 0.387982517534552 1902 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1644 st010134 20.9 µM 0.284320058363737 0.390248192860849 no 1284 0.388082557908458 1924 3818134
SGTC_1045 1348-1485 165 µM 0.284141070355447 0.390316749992311 no 1285 0.388151136936171 1837 6810614
SGTC_322 k048-0136 19.3 µM 0.281443393937832 0.391350443235265 no 1286 0.389185169512725 1853 6823282
SGTC_2459 5811157 9.22 µM 0.280937344867063 0.39154443641145 no 1287 0.389379228289731 1894 2870684 YBR192W RIM2
SGTC_2511 berberine 10.47 µM 0.277381314623167 0.392908393660625 no 1288 0.390743663855136 1789 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1320 1313-0481 95.3 µM 0.277063127397289 0.393030502504159 no 1289 0.390865816976773 1948 6813365 YLR208W SEC13
SGTC_1441 4106-0040 13 µM 0.27703939402783 0.393039610942011 no 1290 0.390874928727035 1834 2904180
SGTC_1098 clofazimine 15.1 µM 0.275830665045045 0.393503576591906 no 1291 0.391339064863547 1899 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2082 5219693 150 µM 0.27521856256139 0.393738587348751 no 1292 0.391574163292111 1779 2834649
SGTC_6 0844-0013 19.835 µM 0.27505549008765 0.393801203962239 no 1293 0.391636803414173 1890 1584900
SGTC_2855 9016525 58.44 µM 0.273501576067515 0.394398013827278 no 1294 0.392233840491894 1821 43811474
SGTC_101 0490-5701 117.494 µM 0.272306788613041 0.394857063110777 no 1295 0.392693068415111 1924 4661669
SGTC_2014 4013930 200 µM 0.27205452743261 0.394954003066719 no 1296 0.392790046525807 1973 64556
SGTC_1144 3486-0183 12.5 µM 0.270003346518104 0.395742480155397 no 1297 0.393578839521982 1848 6744069
SGTC_2828 7998861 71.43 µM 0.269339133335068 0.395997896369143 no 1298 0.393834360194818 1964 2988188
SGTC_1730 st033808 45.1 µM 0.269080853310715 0.396097227308753 no 1299 0.39393373203902 1812 1045166
SGTC_2275 7947463 200 µM 0.268296522447221 0.39639891148059 no 1300 0.394235541407723 1958 1225414
SGTC_1041 0206-0046 107 µM 0.26803555840379 0.396499302171181 no 1301 0.394335974080937 1819 50494
SGTC_1230 0170-0365 3.77 µM 0.267838788313129 0.396575002521682 no 1302 0.394411706194777 1947 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_822 1487-0950 154 µM 0.26688540105261 0.396941839792264 no 1303 0.394778698678424 1956 1958375
SGTC_169 k015-0017 16.025 µM 0.266693571467809 0.39701566158824 no 1304 0.394852551967786 1910 1840002
SGTC_2028 5153890 36.43 µM 0.265967406894448 0.397295144968382 no 1305 0.395132155363687 1823 2830968 YPR165W RHO1
SGTC_510 ag-490 170 µM 0.264318607819653 0.397929923926807 no 1306 0.395767211515318 1974 5328779
SGTC_3199 9111318 49.47 µM 0.26425908726309 0.397952844092358 no 1307 0.395790141809137 1904 8548020
SGTC_1515 3460-0031 42.1 µM 0.2636476506882 0.398188316360253 no 1308 0.396025718612924 1901 2876596
SGTC_1381 2324-0066 62.1 µM 0.263297149706454 0.398323315625999 no 1309 0.396160778206732 1855 10885928
SGTC_3165 9101544 49.47 µM 0.262083696342861 0.398790784294748 no 1310 0.396628458006681 1913 5002184
SGTC_982 1491-0518 27.5 µM 0.259509978041315 0.399782758964995 no 1311 0.397620892150604 1856 3091256
SGTC_1119 parthenolide 318.541 nM 0.259322985349899 0.399854855865652 no 1312 0.39769302305196 1911 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_150 3970-0969 77.2 µM 0.258749734969772 0.400075899544176 no 1313 0.397914171485474 1860 6615640
SGTC_2084 5306078 60.6385 µM 0.258363613271316 0.400224804998363 no 1314 0.398063147942195 1899 679340
SGTC_117 lucigenin 22.078 µM 0.257428719178623 0.400585401185776 no 1315 0.398423917521313 1749 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1293 1000-1278 195 µM 0.257331897043844 0.400622751111437 no 1316 0.39846128552374 1917 678847
SGTC_1187 1391-0724 117 µM 0.256692706178551 0.400869346968399 no 1317 0.398708001280794 1878 6997986
SGTC_1783 st039459 87.517 µM 0.256562377186895 0.400919631933966 no 1318 0.398758310813553 1974 729761
SGTC_3021 9087658 49.47 µM 0.256316133440654 0.401014644885928 no 1319 0.398853370293687 1976 25237042
SGTC_2725 haloperidol 53.21 µM 0.25529442453028 0.401408932934335 no 1320 0.399247852944813 1895 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_836 0330-0104 1.35 µM 0.255016536244095 0.40151619028703 no 1321 0.399355163658098 1875 46494820
SGTC_1623 st003709 20.3 µM 0.254655163851174 0.401655681341882 no 1322 0.399494724380481 1793 16192618
SGTC_816 0325-0417 81.3 µM 0.254520100245082 0.401707819601902 no 1323 0.399546888759027 1836 68101
SGTC_736 0958-0254 92.6 µM 0.254360818104487 0.401769309129439 no 1324 0.399608409144502 1891 6812352
SGTC_787 4152-0075 138 µM 0.254331818814172 0.401780504322711 no 1325 0.399619609962372 1864 9566539
SGTC_256 clotrimazole 625 nM 0.252546293702396 0.402469962272987 no 1326 0.400309418099016 1864 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1080 nisoldipine 24.4 µM 0.252509481107304 0.402484180191499 no 1327 0.400323643317575 1846 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.251657623955459 0.402813224109357 no 1328 0.40065285706577 1951 16725076
SGTC_2059 5238311 157 µM 0.251651711043288 0.402815508310371 no 1329 0.40065514245167 1830 703021
SGTC_328 k915-0120 63.5 µM 0.249620789042101 0.403600263992671 no 1330 0.401440310051149 1976 6624543
SGTC_2191 5911152 200 µM 0.249441001608532 0.403669753266899 no 1331 0.401509836265064 1867 2875902
SGTC_2719 novobiocin 32.65 µM 0.249249210996367 0.403743885217325 no 1332 0.40158400770649 1962 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2357 9067248 200 µM 0.248265778196367 0.404124061280325 no 1333 0.401964387645047 1880 9150235
SGTC_140 0062-0056 502.533 µM 0.247613601941817 0.404376229952067 no 1334 0.402216692793034 1836 3758964
SGTC_2583 asiatic acid 100 µM 0.24736073642652 0.40447401292933 no 1335 0.402314528958835 1886 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2148 5546263 113.568 µM 0.246244058203291 0.404905903160052 no 1336 0.402746655900532 1867 792097
SGTC_923 1900-2434 73.3 µM 0.245632421798381 0.405142510859591 no 1337 0.4029833945149 1817 5910570
SGTC_2289 7946404 165.07 µM 0.2449902807441 0.405390956403927 no 1338 0.403231978463891 1840 1246120 YPR165W RHO1
SGTC_1215 3852-0577 11.2 µM 0.244427998834373 0.405608535611582 no 1339 0.403449679671581 1967 2884876
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.24419992988787 0.405696796921741 no 1340 0.403537990681576 1853 688803
SGTC_824 1304-0008 100 µM 0.244000591388165 0.405773943648555 no 1341 0.403615180949029 1875 768245
SGTC_2896 9052656 71.43 µM 0.243720024791805 0.405882532960043 no 1342 0.403723831704045 1926 6469436
SGTC_1793 st048256 72.231 µM 0.243169669189141 0.406095561298427 no 1343 0.40393698111459 1926 672022
SGTC_149 3970-0822 46.1 µM 0.242006426659942 0.406545913643422 no 1344 0.404387591736974 1840 3114250 YBL034C STU1
SGTC_2561 acetosyringone 100 µM 0.240796013657807 0.407014659416868 no 1345 0.404856609686297 2013 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2412 st077135 33.4 µM 0.240279958214611 0.407214548121055 no 1346 0.405056615493625 1947 13258915
SGTC_2508 celastrol 40.54 µM 0.23935394118768 0.40757329173505 no 1347 0.405415570830356 1984 122724 Celastrol is a natural product and antioxidant.
SGTC_1421 4029-0249 71.4 µM 0.239014089026607 0.407704971619718 no 1348 0.405547328930723 2011 2894095
SGTC_2361 9034121 116 µM 0.238687345056574 0.407831582407641 no 1349 0.405674015177009 1866 6496917
SGTC_1411 3909-8223 150 µM 0.237848050760016 0.408156846614592 no 1350 0.405999474376552 1985 X1411
SGTC_2815 7968870 71.43 µM 0.235442778784708 0.409089347342265 no 1351 0.406932543211929 1845 2977326 YHR190W ERG9
SGTC_534 k292-0788 63.4 µM 0.235402105929516 0.409105120255992 no 1352 0.406948325850715 2043 4146317
SGTC_1557 sumaresinolic acid 42.3 µM 0.235225665109102 0.409173545625195 no 1353 0.407016793453289 1853 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_843 0310-0051 143 µM 0.234383029490779 0.409500365585172 no 1354 0.407343816130794 1905 2065037
SGTC_1964 st076914 61 µM 0.234295779522169 0.409534209469869 no 1355 0.407377681102242 1955 24208661
SGTC_2328 6201408 200 µM 0.233437685911552 0.409867096144161 no 1356 0.407710776127456 1858 2890418
SGTC_602 3130-1533 38.1 µM 0.233204759537615 0.409957468237617 no 1357 0.407801205079321 1986 720941
SGTC_629 3448-6466 76.7 µM 0.232371406146298 0.410280836541667 no 1358 0.408124777865694 1907 573744
SGTC_2594 a-mangostin 100 µM 0.232344563360784 0.410291253433621 no 1359 0.408135201371601 1994 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1001 4048-4355 44.4 µM 0.231913724317964 0.410458457992572 no 1360 0.408302512322011 1872 21824233
SGTC_1501 4491-0275 38.4 µM 0.231515103536167 0.410613173446135 no 1361 0.408457326604202 2016 5104718
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.231323984780948 0.410687356713459 no 1362 0.408531557388923 1861 442882
SGTC_2471 5466956 24.79 µM 0.229962695899901 0.411215836987839 no 1363 0.409060378629407 1939 724419
SGTC_742 0kpi-0133 140 µM 0.229431352387855 0.411422159223017 no 1364 0.40926683514699 2009 2728852
SGTC_2903 5923464 63.88 µM 0.229239582795216 0.411496629934591 no 1365 0.409341354487814 2033 2876576
SGTC_529 4076-0302 30.3 µM 0.228577984531901 0.411753575696788 no 1366 0.409598468689986 1875 5816522
SGTC_93 0109-0045 59.227 µM 0.226736652531856 0.412468895063356 no 1367 0.410314262325797 2025 88733
SGTC_509 pifithrin 175 µM 0.225914112939516 0.412788528788523 no 1368 0.410634110513143 1947 4817 A p53 inhibitor.
SGTC_1993 st073995 70.8 µM 0.225772865522261 0.412843422472832 no 1369 0.410689041186741 1926 3098394
SGTC_1129 3453-1384 223 µM 0.224262953376965 0.413430333401731 no 1370 0.411276350484062 1928 1084452
SGTC_1455 4262-0120 131 µM 0.223170106846913 0.413855249474985 no 1371 0.411701558263927 1976 1529587
SGTC_2094 5332512 191.667 µM 0.223116400263765 0.413876134051445 no 1372 0.411722457248987 1991 755774
SGTC_3294 9122953 26.2835 µM 0.221745327224761 0.414409377828413 no 1373 0.4122560711791 1931 16459826
SGTC_1179 1021-1431 9.29 µM 0.21874069125697 0.415578504609332 no 1374 0.413426024715807 1937 2840958
SGTC_3202 9113761 49.47 µM 0.217954448617278 0.415884561471383 no 1375 0.413732301451511 2029 4798415
SGTC_1642 st009582 77.7 µM 0.217899576276219 0.415905923268567 no 1376 0.413753678648465 2038 6739311
SGTC_159 3970-0959 50 µM 0.217533682470444 0.416048372041938 no 1377 0.413896230291209 1992 6615653
SGTC_796 1234-0020 70.7 µM 0.217265969150134 0.416152604446278 no 1378 0.414000538162761 1962 46495034
SGTC_1513 0337-0559 19 µM 0.217254943323854 0.416156897405053 no 1379 0.414004834233307 1858 775073
SGTC_3064 1327-0027 10 µM 0.215371023098222 0.416890557313327 no 1380 0.414739030057611 1939 16000455 YPR107C YTH1
SGTC_1048 3161-0300 24.5 µM 0.215323700332717 0.416908990078298 no 1381 0.414757476392572 1949 2165101
SGTC_2737 bleomycin 30.5 nM 0.215241949680722 0.416940833333913 no 1382 0.414789343102991 1975 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2125 5246583 200 µM 0.214911419378407 0.417069586006178 no 1383 0.414918190767813 2078 835267
SGTC_1896 st058441 89 µM 0.211033382359482 0.418580872683435 no 1384 0.416430611270713 1880 688759
SGTC_1786 berberine 21.6 µM 0.210584316999914 0.418755953379352 no 1385 0.416605825556898 1903 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1787 fluconazole 80 µM 0.210551038491127 0.418768928578109 no 1386 0.416618810674478 1949 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3302 9125395 16.351 µM 0.210313252194737 0.418861643369751 no 1387 0.416711596415632 1935 17599668
SGTC_1060 3448-7350 82 µM 0.207579406704965 0.419927914243729 no 1388 0.417778692593712 2032 570178
SGTC_2128 5255449 168.493 µM 0.207087054412582 0.420120007163914 no 1389 0.417970936021986 1943 736008
SGTC_3025 9087895 49.47 µM 0.204829537934548 0.421001027879104 no 1390 0.418852654164017 2056 17173641
SGTC_682 0kpi-0099 17 µM 0.202844080940879 0.421776201639112 no 1391 0.419628451233094 1902 1714895 YML126C ERG13
SGTC_678 1218-2179 85.9 µM 0.202157925937846 0.422044164948567 no 1392 0.419896632111943 2007 6820081 YOR116C RPO31
SGTC_3054 9094397 49.47 µM 0.201473383466864 0.422311534484215 no 1393 0.42016421981068 1931 2598354
SGTC_2870 9038528 12.99 µM 0.200964514903582 0.422510312271577 no 1394 0.420363160489024 1958 6463316
SGTC_128 0906-2981 13.371 µM 0.200561989617668 0.422667563488968 no 1395 0.420520540988315 2057 6740226
SGTC_2763 lisinopril 49.32 µM 0.200451300131013 0.422710807794926 no 1396 0.420563820912062 2091 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1338 1486-1223 76 µM 0.200361941366459 0.422745719267442 no 1397 0.420598761159582 2013 3444526
SGTC_3270 9137563 49.47 µM 0.199677870058684 0.423012998379571 no 1398 0.420866261176628 2023 17015724
SGTC_1563 conessine 56.1 µM 0.199382613522864 0.423128371439126 no 1399 0.420981729922636 2060 441082 An anti-amoebic, histamine inhibitor.
SGTC_3346 9158254 43.5805 µM 0.19892551354932 0.423306998681691 no 1400 0.421160505706288 1960 17639500
SGTC_766 1391-0721 126 µM 0.198427664642886 0.423501567879764 no 1401 0.421355237246587 2034 1020919 YIL115C NUP159
SGTC_1904 st060225 78 µM 0.198164970219779 0.423604241576999 no 1402 0.421457996840108 1983 66595
SGTC_1433 4060-0023 7.6 µM 0.197838612679043 0.423731805126845 no 1403 0.421585667328968 2021 3840627
SGTC_2984 9022109 38.96 µM 0.195312073332116 0.42471962440818 no 1404 0.422574322964776 2113 6459207
SGTC_818 4072-2707 53.5 µM 0.194756962330815 0.424936723741891 no 1405 0.422791608065396 1972 882871
SGTC_658 3253-0951 102 µM 0.194680058716656 0.424966801908143 no 1406 0.422821712024385 1979 1184878
SGTC_501 nsc-95397 161 µM 0.193885060747885 0.425277763200902 no 1407 0.423132940765744 2041 262093
SGTC_2705 st078069 42.8 µM 0.193709457087197 0.425346456370583 no 1408 0.423201693211085 1952 1530061
SGTC_1160 4092-0570 10.5 µM 0.193089818111583 0.425588866708236 no 1409 0.423444313288525 1883 4994975
SGTC_1734 st037168 69.4 µM 0.189970546991478 0.426809589067122 no 1410 0.4246661051621 1885 708907
SGTC_152 4469-0003 551.229 µM 0.188832780769527 0.427255027457124 no 1411 0.425111939339962 2113 697280
SGTC_2699 st077704 54.6 µM 0.188103229990588 0.427540697301354 no 1412 0.42539786456459 1979 645852
SGTC_2474 5321570 43.32 µM 0.187156783453355 0.427911353506997 no 1413 0.42576885393293 2066 2841384
SGTC_1880 MG-132 525 µM 0.186910835841456 0.428007684228749 no 1414 0.425865271575095 2063 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1567 st069303 68.4 µM 0.186751487855289 0.428070098617926 no 1415 0.425927742355084 1953 5581319
SGTC_2283 7944793 200 µM 0.186620803427306 0.42812128723339 no 1416 0.425978977262128 1927 2970533
SGTC_3147 9097027 49.47 µM 0.186459208883806 0.428184584901221 no 1417 0.426042332225926 1997 25236841
SGTC_3351 9150312 21.596 µM 0.185084779823902 0.428723032529342 no 1418 0.426581269650396 2089 4904905
SGTC_3079 9117512 49.47 µM 0.184157172392656 0.429086507953868 no 1419 0.426945078138052 2028 7185044
SGTC_145 3737-0113 38.366 µM 0.183924287834157 0.429177771329965 no 1420 0.427036425448777 2099 6849351
SGTC_2912 7964298 10.93 µM 0.183333007953586 0.429409500548017 no 1421 0.427268368341439 1956 2975850
SGTC_414 piperonyl butoxide 100 µM 0.182578699758421 0.429705157693907 no 1422 0.427564299262723 1944 5794 A potent inhibitor of cytochrome P450.
SGTC_88 0180-0332 8.668 µM 0.182400009867082 0.429775202412348 no 1423 0.427634409031274 2026 3101745
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.1817033326236 0.43004831427992 no 1424 0.427907775229001 1963 6708514
SGTC_102 gallobenzophenone 83.616 µM 0.179951799623779 0.430735098972531 no 1425 0.428595204346333 2075 70837
SGTC_506 n9-isopropylolomoucine 153 µM 0.17985671491898 0.430772388167222 no 1426 0.428632528729577 2126 6610355
SGTC_756 0508-1999 28.3 µM 0.178789822975087 0.431190831468231 no 1427 0.429051368307931 1882 6753853
SGTC_1102 cgs 12066b 26.1 µM 0.178620922852816 0.431257082501318 no 1428 0.429117682319334 1993 6438352 A 5-HT1B full agonist.
SGTC_717 1532-0246 73.2 µM 0.178379331390321 0.431351850056857 no 1429 0.429212540073491 1976 9561992
SGTC_2551 apiole 73.87 µM 0.176261216961728 0.43218287802487 no 1430 0.43004436467021 2080 10659 A possible DNA adduct former.
SGTC_825 1988-2224 89.6 µM 0.174605592762617 0.432832660245724 no 1431 0.430694776855166 1986 1180859
SGTC_1323 1348-1351 11.2 µM 0.174584529821917 0.432840927984266 no 1432 0.430703052649266 1946 6989654
SGTC_1724 st037281 8.293 µM 0.173741722054883 0.433171775498905 no 1433 0.431034223344664 1965 574124 YDL195W SEC31
SGTC_399 oxolinic acid 75 µM 0.1736354336045 0.433213502780538 no 1434 0.431075991500771 1984 4628 A DNA gyrase inhibitor.
SGTC_834 0312-0008 75.7 µM 0.172874233233208 0.433512360578459 no 1435 0.43137514279552 2031 6385573 YIL048W NEO1
SGTC_641 4092-0595 30 µM 0.172753088023466 0.433559927375332 no 1436 0.431422756426823 2047 786260
SGTC_125 0133-0007 11.75 µM 0.172004199874087 0.433853994266646 no 1437 0.431717113594125 2125 26541
SGTC_955 1216-0110 33 µM 0.171765730128478 0.433947642187928 no 1438 0.431810854222269 1994 3619719
SGTC_2356 9061756 188.97 µM 0.171489895053407 0.434055968231749 no 1439 0.431919287663917 2101 20104043
SGTC_3122 9126309 49.47 µM 0.171224874299088 0.434160051936991 no 1440 0.432023474722987 2140 17591206
SGTC_3170 9103054 49.47 µM 0.168833753404616 0.435099341357903 no 1441 0.432963704021547 1999 16432970
SGTC_1291 0993-0025 5.79 µM 0.168252110616911 0.435327880141224 no 1442 0.433192473439003 2091 4353356
SGTC_1154 4088-0362 150 µM 0.166320869417942 0.43608685697008 no 1443 0.433952221678314 2106 6618304
SGTC_1051 3253-3903 78 µM 0.166082777108339 0.436180443486026 no 1444 0.43404590389632 2083 5509239
SGTC_204 PMA1.184 62.41 µM 0.165764773709925 0.436305446082275 no 1445 0.43417103452019 2116 2252213 YGL008C PMA1
SGTC_1318 1280-3875 124 µM 0.164757121176049 0.436701581867558 no 1446 0.434567577532838 2050 373245
SGTC_929 2805-0021 398 µM 0.163551906440624 0.437175468104 no 1447 0.435041953928106 2012 3098024
SGTC_1326 1431-2094 10.8 µM 0.161983589350385 0.437792259806101 no 1448 0.435659388498204 1945 616278
SGTC_1019 4262-0212 3.4 µM 0.16197508403907 0.437795605209898 no 1449 0.435662737403928 2135 4677213
SGTC_2238 6671620 73.2395 µM 0.161342690175631 0.438044357848555 no 1450 0.435911750889608 2139 729941
SGTC_1934 st074720 32.6 µM 0.161198192117053 0.438101199716799 no 1451 0.435968652489616 2069 17250992
SGTC_1265 0819-1001 68.8 µM 0.160947636715326 0.438199764878142 no 1452 0.436067321338553 2097 3106768
SGTC_3029 9088683 49.47 µM 0.160570745666636 0.438348036021048 no 1453 0.436215748724097 2043 25236615
SGTC_15 0266-0086 27.098 µM 0.160231836694897 0.438481372183346 no 1454 0.436349225663772 2129 1712902 YIL048W NEO1
SGTC_2994 9053520 71.4286 µM 0.160206198459339 0.438491459258559 no 1455 0.436359323399504 2100 4647384
SGTC_713 1488-1073 324 µM 0.160199131810556 0.43849423955901 no 1456 0.436362106638572 2131 3312542
SGTC_1469 k284-2957 126 µM 0.159778605685948 0.438659696707729 no 1457 0.43652773886806 2080 23884841
SGTC_1149 3909-7961 23.3 µM 0.159504046974787 0.438767728366642 no 1458 0.436635885056585 1961 735261
SGTC_1950 st077106 7.18 µM 0.158688712046956 0.439088568155728 no 1459 0.436957065981711 1973 13831864
SGTC_2753 fluvastatin 17.09 µM 0.157475008896151 0.439566242595452 no 1460 0.437435251078727 2046 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1113 artemisinin 1.17947 µM 0.157039917097257 0.439737502167511 no 1461 0.437606694540799 2156 2240 An anti-malaria and mitochondrial poison.
SGTC_2662 daunorubicin 22.37 µM 0.156418040231383 0.43998230310728 no 1462 0.4378517590731 2100 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1507 4075-3230 155 µM 0.155642629774044 0.440287574459721 no 1463 0.43815736034558 2152 659771
SGTC_3156 9099931 49.47 µM 0.155189817936034 0.440465858386525 no 1464 0.438335837575159 2029 18111053
SGTC_75 0159-0059 199.013 µM 0.155167092531293 0.440474806294278 no 1465 0.438344795196717 2112 5377270
SGTC_1259 0671-0132 43 µM 0.154939808240533 0.440564298951302 no 1466 0.438434385070212 1995 X1259
SGTC_1666 st014829 29 µM 0.154110398285961 0.440890902897745 no 1467 0.438761344790879 2041 3858230
SGTC_1661 st013063 9.66 µM 0.153348704163902 0.441190877218614 no 1468 0.439061647235698 2063 721395
SGTC_2168 5727979 200 µM 0.152855191085167 0.441385253117376 no 1469 0.439256236444351 2135 695210
SGTC_468 gf-109203x 121 µM 0.152695405182371 0.441448189692119 no 1470 0.439319242203138 2144 2396 A protein kinase C inhibitor.
SGTC_2005 4024620 188 µM 0.152689879588971 0.441450366142878 no 1471 0.439321421047419 2102 236743
SGTC_983 1491-0821 12.2 µM 0.150638177823617 0.442258623237522 no 1472 0.440130571735097 2141 46495113
SGTC_1387 3342-1166 1.8 µM 0.149738045227236 0.442613301807083 no 1473 0.440485645402287 2050 3418228
SGTC_1600 coumarin 106 71.1 µM 0.149715447642592 0.442622206509418 no 1474 0.440494560047411 2082 100336 A hepatotoxic, DNA x-linker.
SGTC_2411 st077133 39.94 µM 0.14938898525227 0.442750854039271 no 1475 0.440623351349545 2153 1403142 YNL221C POP1
SGTC_1811 st050069 61.5 µM 0.148699328915048 0.443022643563071 no 1476 0.440895445399536 2169 3877702
SGTC_2712 st079126 47.7 µM 0.146898500196804 0.44373246570975 no 1477 0.441606067875048 2079 3152970
SGTC_3336 9143619 71.43 µM 0.144731518647883 0.444586851351775 no 1478 0.442461426438718 2150 45595730
SGTC_811 0416-0114 265 µM 0.144545577309653 0.444660175339666 no 1479 0.442534834411352 2023 6612453
SGTC_1519 esterone 74 µM 0.144203194012914 0.444795195501202 no 1480 0.442670009425588 1924 698 A steroid.
SGTC_730 1436-0052 41.2 µM 0.143697999795794 0.444994432465553 no 1481 0.442869475369171 2187 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1256 0570-0116 285 µM 0.143615069276624 0.4450271396815 no 1482 0.442902220229242 2030 410638
SGTC_1936 st074407 74.3 µM 0.143613211308568 0.445027872455376 no 1483 0.442902953846674 1985 809813
SGTC_253 dyclonine 31.25 µM 0.143011773165441 0.445265086692602 no 1484 0.443140441564862 2080 3180 An oral anasthetic.
SGTC_2650 prasterone 100 µM 0.142278005943085 0.445554519600206 no 1485 0.443430209246788 2140 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3114 9122766 49.47 µM 0.141539905192316 0.445845691136647 no 1486 0.44372171877808 2010 17176985
SGTC_591 4299-0174 154 µM 0.140868568517682 0.446110550447799 no 1487 0.443986886593647 2086 5509088
SGTC_1449 4112-4002 201 µM 0.139520318523651 0.446642541721363 no 1488 0.444519500552188 1984 2059539
SGTC_864 0469-0573 172 µM 0.139227946592835 0.446757918280202 no 1489 0.444635012690299 1976 689425
SGTC_639 0833-0042 114 µM 0.137620907096954 0.447392172523412 no 1490 0.445270015639385 2016 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1633 st005664 67.9 µM 0.136930690347435 0.447664623471668 no 1491 0.44554278996381 2094 2063822
SGTC_1073 triclabendazole 3.09 µM 0.13659862355987 0.447795709814234 no 1492 0.445674032271626 2058 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2502 avocadyne acetate 18.59 µM 0.134650108038621 0.448565018216588 no 1493 0.446444260920763 2183 3952079
SGTC_3241 9133421 49.47 µM 0.134506109225372 0.448621879207579 no 1494 0.446501190263085 2172 17018221
SGTC_323 4013-0906 34.3 µM 0.133839034555397 0.448885301565499 no 1495 0.446764929874945 2180 2910086
SGTC_1456 k015-0012 13 µM 0.133527340211887 0.449008394856498 no 1496 0.44688817175205 2199 2989616
SGTC_2188 6126565 140.678 µM 0.132779050515872 0.449303926941751 no 1497 0.447184061453397 2149 874518
SGTC_2555 cholic acid 100 µM 0.132272876159575 0.449503853126224 no 1498 0.447384230266977 2079 6708657 Influences liver metabolism.
SGTC_770 0389-1121 67.2 µM 0.13182275028538 0.449681652335327 no 1499 0.447562245728693 2166 6753108
SGTC_597 k018-0003 82.8 µM 0.13051437363879 0.450198516855865 no 1500 0.448079741445056 2146 6786234
SGTC_3133 9127736 49.47 µM 0.12888805644897 0.450841099114349 no 1501 0.448723113705992 2210 27243420
SGTC_463 ikarugamyin 104 µM 0.128598633831054 0.450955467877029 no 1502 0.448837623688716 2176 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_978 1416-0512 87.4 µM 0.127771887727195 0.45128218875233 no 1503 0.449164749011473 2072 6814003
SGTC_3333 9141820 12.094 µM 0.126596537757951 0.451746730766693 no 1504 0.449629868681129 2049 1939433
SGTC_943 3253-1379 105 µM 0.126259544423302 0.451879935280964 no 1505 0.449763239397112 2134 668464
SGTC_2862 9027634 71.43 µM 0.123499540790957 0.452971093946806 no 1506 0.4508557689519 2066 5012562
SGTC_236 1509-0011 5.31 µM 0.12336501688707 0.453024286689784 no 1507 0.450909028953458 2161 3107280
SGTC_905 2-aminofluorene 215 µM 0.122701405960876 0.453286700590939 no 1508 0.451171775242566 2193 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3104 9120930 49.47 µM 0.122078845685081 0.453532900242904 no 1509 0.451418287626592 2096 17014836
SGTC_1171 0368-0077 21.4 µM 0.122061189902269 0.453539882715388 no 1510 0.451425278980922 2082 3239779
SGTC_1926 methyl fluorone black 53.6 µM 0.1218306995822 0.453631037867432 no 1511 0.451516550147137 2168 72721 Reacts with homocysteine.
SGTC_1920 st075728 45.7 µM 0.119584675240449 0.45451943092369 no 1512 0.452406079992784 2206 3400306
SGTC_3201 9113999 49.47 µM 0.118406849132644 0.4549853998085 no 1513 0.452872649567427 2148 16649224
SGTC_2684 capsaicin 100 µM 0.117608065712873 0.455301447976699 no 1514 0.453189106894678 2138 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_739 1486-1183 203 µM 0.11726561706717 0.455436950535827 no 1515 0.453324785306007 2207 4346692
SGTC_2019 4016004 108 µM 0.116848139334365 0.455602148158305 no 1516 0.453490197666637 2096 45595336
SGTC_1636 st007707 68.9 µM 0.116341054269506 0.455802814085724 no 1517 0.453691124951655 2166 403051
SGTC_497 capsazepine 133 µM 0.116193623852077 0.455861158015398 no 1518 0.453749544977366 2109 2733484 A calcium channel blocker.
SGTC_1457 k015-0032 57.3 µM 0.115713596908022 0.456051129868375 no 1519 0.453939764934788 2189 4302660
SGTC_2401 5128683 200 µM 0.11491509013 0.456367163141962 no 1520 0.454256212069825 2109 708373
SGTC_2075 5212009 200 µM 0.114456192940481 0.45654879812474 no 1521 0.45443808554554 2189 780898
SGTC_2287 7945887 168.79 µM 0.112866376426613 0.45717812951416 no 1522 0.455068246838694 2191 1245853
SGTC_2981 9013952 38.96 µM 0.112624145967096 0.457274026293787 no 1523 0.455164270564281 1974 2996344
SGTC_2095 5432005 200 µM 0.111247622501978 0.457819026169528 no 1524 0.455709994338183 2148 783734
SGTC_808 0711-0032 135 µM 0.111135931736651 0.457863250814334 no 1525 0.455754277906479 2217 4252555
SGTC_3014 9081533 49.47 µM 0.111031558139556 0.457904578652978 no 1526 0.455795660833676 2216 21367265
SGTC_2224 6650123 117.647 µM 0.110831182011847 0.457983920992466 no 1527 0.455875109000518 2177 2908370
SGTC_1887 st057648 70.8 µM 0.110126759585912 0.458262862314287 no 1528 0.456154423073396 2197 688672
SGTC_2731 amoxapine 43.43 µM 0.10955064482458 0.458491010901809 no 1529 0.456382877344113 2248 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1760 st045453 10.4495 µM 0.10921278337249 0.458624814591481 no 1530 0.456516860647259 2210 3323419 YIL048W NEO1
SGTC_1838 st055369 84.5 µM 0.108672404389221 0.458838831289229 no 1531 0.456731165152359 2219 676036
SGTC_9 0092-0002 10.449 µM 0.108665762770988 0.458841461771579 no 1532 0.456733799176123 2215 759368
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.108235880513011 0.459011724963195 no 1533 0.456904291797834 2203 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_700 3453-2283 142 µM 0.107655556157254 0.459241585581402 no 1534 0.457134462794203 2185 565664
SGTC_286 k060-0067 22.9 µM 0.107481586664138 0.45931049579942 no 1535 0.457203466204205 2148 5985051
SGTC_450 aminopyrene 156 nM 0.105437106734195 0.460120415949463 no 1536 0.458014486615214 2216 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3006 9075424 71.4286 µM 0.103827896968761 0.460758020513241 no 1537 0.458652963765588 2126 7465181
SGTC_184 1494-0393 24.714 µM 0.103486964694405 0.460893118442831 no 1538 0.458788247306529 2148 3090647
SGTC_2915 7971052 15.16 µM 0.101331165217637 0.461747480088681 no 1539 0.45964378862321 2238 5741558
SGTC_865 0488-0499 301 µM 0.100267046748576 0.462169264604927 no 1540 0.460066159252489 2238 9634651
SGTC_160 3453-0671 289.699 µM 0.0993273284895409 0.462541776015555 no 1541 0.460439190353519 2201 5322268
SGTC_2301 7769476 200 µM 0.0985154497660731 0.46286363733603 no 1542 0.460761502247845 2164 977820
SGTC_2427 5545055 42.75 µM 0.0983641364356371 0.462923626709359 no 1543 0.460821575758646 2163 5372858
SGTC_3337 9144342 33.5465 µM 0.0981417379937774 0.463011799870571 no 1544 0.460909872676468 2205 17682949
SGTC_368 fentichlor 4.58 µM 0.0975158449524441 0.463259954190743 no 1545 0.461158375873412 2121 7329 A pesticide.
SGTC_1166 k206-0078 225 µM 0.097042543030992 0.463447618622284 no 1546 0.461346304704544 2211 5404595
SGTC_1778 st046819 58.9 µM 0.0966673427832877 0.463596391476649 no 1547 0.461495287509801 2222 671715
SGTC_1109 tnp00067 928.257 nM 0.0964606705853821 0.463678342459768 no 1548 0.461577354274072 2107 676295
SGTC_3145 9085516 49.47 µM 0.096392051921098 0.463705551912834 no 1549 0.461604602189411 2037 25236195
SGTC_679 0422-0091 41.4 µM 0.0957894795577078 0.463944498035789 no 1550 0.461843886516403 2197 627384 YHR062C RPP1
SGTC_1553 gossypol 38.6 µM 0.095503809417119 0.464057783208309 no 1551 0.461957332307771 2221 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_891 0929-0073 133 µM 0.0942937398352733 0.464537679851645 no 1552 0.46243791132375 2211 5603632
SGTC_113 0099-0221 2.5 µM 0.0937397538081645 0.464757400207083 no 1553 0.462657945161919 2238 89219
SGTC_1743 st037606 46.3785 µM 0.0930211756907747 0.465042416607674 no 1554 0.462943369195699 2183 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2529 gangaleoidin 93.61 µM 0.0925850070765382 0.465215427026244 no 1555 0.463116627600688 2191 4565183
SGTC_708 3448-5400 146 µM 0.0921421901093738 0.46539108130359 no 1556 0.463292534075295 2247 3462195
SGTC_1378 2093-0007 380 nM 0.0917544319288862 0.465544900693616 no 1557 0.463446574661394 2151 3618014
SGTC_1348 1493-0373 93.8 µM 0.0908021322319408 0.465922689270979 no 1558 0.463824907888284 2193 3010129
SGTC_3355 9151058 44.0485 µM 0.0905427519983046 0.46602559381994 no 1559 0.463927961132293 2259 17015728
SGTC_330 1488-0319 80.1 µM 0.0897763700078103 0.46632965565006 no 1560 0.464232463175404 2139 6846614
SGTC_1155 4088-0394 48.2 µM 0.0897099868777984 0.466355994064892 no 1561 0.464258839782056 2118 2326248
SGTC_2387 9077560 195.08 µM 0.0889938088557101 0.466640156837064 no 1562 0.464543415207728 2161 5303272
SGTC_3091 9116372 49.47 µM 0.087618600623435 0.467185855014247 no 1563 0.465089908938527 2171 17169793
SGTC_395 anisomycin 6.25 µM 0.0875010530408923 0.467232502100149 no 1564 0.4651366242189 2130 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_420 mitomycin C 81.9 mM 0.0870712977967979 0.467403048180504 no 1565 0.46530741987832 2229 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1862 st057513 3.81 µM 0.0867090909280381 0.467546792696135 no 1566 0.465451375060705 2231 5393163
SGTC_1115 galangin 695.678 nM 0.0859676687819374 0.467841044819442 no 1567 0.465746059311569 2234 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1522 st012842 45.6 µM 0.0850154193027548 0.468218994855867 no 1568 0.466124566129469 2231 3491067 YOR116C RPO31
SGTC_2321 7390090 138.78 µM 0.0834750563070515 0.468830429019878 no 1569 0.466736905170491 2133 649046
SGTC_3252 9135871 49.47 µM 0.0834167151239785 0.468853588517048 no 1570 0.4667600990424 2227 17682838
SGTC_543 3844-1095 191 µM 0.0818184602725398 0.469488082928938 no 1571 0.467395538058088 2224 4230703
SGTC_2619 obliquin 87.91 µM 0.0810468560582552 0.469794431475201 no 1572 0.467702344647154 2222 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1846 st056244 14.8 µM 0.0809203939698317 0.469844642186675 no 1573 0.467752630554177 2195 5393182
SGTC_1108 betulinic acid 729.144 nM 0.0809019408807353 0.469851968871029 no 1574 0.467759968213845 2242 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3056 9094900 49.47 µM 0.0807309725593563 0.469919851265658 no 1575 0.467827952330547 2185 25236784
SGTC_892 0929-0076 29 µM 0.0807052557105919 0.469930062129301 no 1576 0.46783817850065 2236 5751038
SGTC_2021 4019055 173 µM 0.0803687663036073 0.470063666921852 no 1577 0.46797198370262 2231 44827708 YER133W GLC7
SGTC_2403 6032726 181.2 µM 0.0798735412347567 0.470260304624269 no 1578 0.468168916807273 2199 2881040
SGTC_2311 7694451 200 µM 0.0795994165081932 0.470369153722508 no 1579 0.468277929652336 2215 2163142
SGTC_393 acivicin 6.25 µM 0.0765359531131054 0.471585738632643 no 1580 0.469496355699849 2205 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_549 1661-1316 519 µM 0.0755181631069185 0.471989990065059 no 1581 0.469901223365476 2266 2857282
SGTC_2060 5238662 140 µM 0.0749238416304912 0.472226059309667 no 1582 0.470137653495654 2198 790130
SGTC_381 3461-2219 42.7 µM 0.0738108039031498 0.472668192980931 no 1583 0.470580465102906 2270 2883159
SGTC_456 gingerol 170 µM 0.0737413160294913 0.472695796877336 no 1584 0.470608111413059 2220 442793 A herb.
SGTC_3221 9128209 49.47 µM 0.0735967985733009 0.472753206520932 no 1585 0.470665609300402 2223 16460723
SGTC_2782 7736369 71.43 µM 0.0705730385676973 0.473954524946249 no 1586 0.471868784500055 2197 2950836 YOL077C BRX1
SGTC_1220 1838-0075 193 µM 0.0702628864797687 0.474077759752872 no 1587 0.471992210884562 2213 5529645
SGTC_1280 0880-0253 10.1 µM 0.0697152817471353 0.474295349258295 no 1588 0.472210139150714 2219 6836607
SGTC_2450 5739737 12.93 µM 0.0686284196548933 0.474727234109254 no 1589 0.47264269828961 2204 2262825
SGTC_3243 9134147 49.47 µM 0.0682988588842361 0.47485819709766 no 1590 0.472773866244083 2295 24282180
SGTC_1000 4048-0884 8.67 µM 0.0675497460671411 0.4751558944726 no 1591 0.473072030397098 2215 13040088
SGTC_1440 4100-1550 40 µM 0.067452529981883 0.475194529157641 no 1592 0.473110725747515 2263 742806
SGTC_2974 9094440 9.66 µM 0.0668498844115973 0.475434031975819 no 1593 0.4733506050897 2221 25236134
SGTC_2652 actinonin 100 µM 0.0664720838698713 0.475584181632956 no 1594 0.473500991192618 2307 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1873 rapamycin 2 nM 0.0658323913872699 0.47583842316755 no 1595 0.473755633782961 2248 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2653 dihydrofissinolide 100 µM 0.06422929116912 0.47647560770639 no 1596 0.474393827280336 2245 6857746
SGTC_1821 st053465 65.6 µM 0.0611568251400506 0.477696988087153 no 1597 0.475617156940969 2228 675086
SGTC_1548 st061468 90.8 µM 0.060292587803719 0.478040581812941 no 1598 0.475961302641829 2298 390799
SGTC_3017 9080681 49.47 µM 0.0601984552676751 0.478078006954498 no 1599 0.475998788001655 2216 16451914
SGTC_1238 0333-0287 48.8 µM 0.0593159710627001 0.478428873705092 no 1600 0.476350220221961 2279 7226
SGTC_705 1124-0212 310 µM 0.0586854238753004 0.478679583114563 no 1601 0.476601334694982 2306 9554485
SGTC_912 3474-0017 2.18 µM 0.0585477921861682 0.478734307439152 no 1602 0.476656147547999 2266 3360550
SGTC_540 1187-0821 17.3 µM 0.0583229297668454 0.47882371680958 no 1603 0.47674570164375 2233 847520
SGTC_430 0958-0115 16.4 µM 0.0579571766231692 0.478969149158082 no 1604 0.476891369629716 2135 6833180
SGTC_1796 st049173 110.4 µM 0.0542004626323281 0.480463068662608 no 1605 0.478387726050392 2313 94134
SGTC_354 2783-3500 4.88 µM 0.0540293530022763 0.480531119933179 no 1606 0.478455889038178 2253 6740761
SGTC_469 w7 172 µM 0.0532094866133307 0.480857193284946 no 1607 0.478782498550187 2310 45115570 A P450 inhibitor.
SGTC_2244 6635614 200 µM 0.0529601902373439 0.480956344800659 no 1608 0.478881813381431 2186 836499
SGTC_192 3455-0609 60.9 µM 0.0516045862028427 0.481495523500886 no 1609 0.47942188247492 2257 3769639
SGTC_2783 7738165 71.43 µM 0.0510856551467909 0.481701932439876 no 1610 0.479628633300961 2243 17201110
SGTC_772 k072-0172 35.3 µM 0.0510475243493037 0.481717099460817 no 1611 0.479643825466305 2224 5861980
SGTC_665 3914-0008 307 µM 0.0509968419409328 0.481737259089295 no 1612 0.479664018520843 2290 1069549
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0504226842681684 0.481965641488624 no 1613 0.479892779972064 2252 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1138 3761-0006 1.03 µM 0.0495530290786424 0.482311575028607 no 1614 0.480239288989163 2307 12061087
SGTC_442 cape 100 µM 0.0489618423506921 0.482546746331823 no 1615 0.480474852420531 2317 5281787
SGTC_595 3909-8003 73.7 µM 0.0483347791192678 0.482796195774585 no 1616 0.480724718603016 2270 699517
SGTC_1340 1486-1359 257 µM 0.0477180355702135 0.483041546556893 no 1617 0.480970480084683 2235 4309068
SGTC_1403 3909-7815 62.9 µM 0.0476863853093406 0.483054137728072 no 1618 0.480983092354149 2281 6615483
SGTC_1090 efavirenz 20.7 µM 0.0451155926187433 0.484076911023713 no 1619 0.482007586482448 2253 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2162 5663267 200 µM 0.0446758663804679 0.484251863952122 no 1620 0.482182835162315 2325 6456493
SGTC_747 3448-8087 38.7 µM 0.0434662945946249 0.484733129204365 no 1621 0.482664916068848 2297 5168703
SGTC_820 1582-0060 59.9 µM 0.0430438625410546 0.484901212035499 no 1622 0.482833284491852 2282 3848840
SGTC_2390 9097792 176.6 µM 0.0419937200554274 0.485319068124008 no 1623 0.483251852186243 2275 4497149
SGTC_2686 alizarin 95.37 µM 0.0410113612978603 0.485709967386336 no 1624 0.483643419238704 2288 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1982 st072467 71.9 µM 0.0402454899177914 0.486014731742547 no 1625 0.483948705638709 2250 3163533
SGTC_2329 6138490 200 µM 0.0382577480240993 0.48680575455081 no 1626 0.484741089148593 2245 720019
SGTC_1983 st071813 46.9 µM 0.0381575933874321 0.486845612534745 no 1627 0.484781015914015 2223 11838595
SGTC_2302 7771753 200 µM 0.0374427374530195 0.487130103569009 no 1628 0.485065998492803 2280 2203047
SGTC_331 k048-0133 24.5 µM 0.0373377126224871 0.487171900829346 no 1629 0.48510786806051 2333 6813582
SGTC_668 1682-0499 62.6 µM 0.0373065678247654 0.487184295708339 no 1630 0.485120284386511 2292 682214
SGTC_2566 crystal violet carbinol 226 nM 0.0349372562287171 0.488127260044978 no 1631 0.486064886281009 2214 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0346336231553627 0.488248108138841 no 1632 0.486185945086872 2316 6708760
SGTC_1106 tegaserod maleate 11.7 µM 0.0342385626199448 0.488405346617777 no 1633 0.486343458016132 2253 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3307 9126885 69.2785 µM 0.0342075061583422 0.488417707510998 no 1634 0.486355840498339 2328 24824909
SGTC_988 1497-1057 103 µM 0.0340607629354764 0.488476113455601 no 1635 0.486414348479351 2339 3533044
SGTC_1239 0337-0584 35.4 µM 0.0338643024760113 0.488554307972752 no 1636 0.486492679674203 2338 914301 YML130C ERO1
SGTC_1976 st070609 63.5 µM 0.0333828096559362 0.488745951945198 no 1637 0.486684658964838 2340 682556
SGTC_1305 1181-0477 144 µM 0.0333511612180891 0.488758548761083 no 1638 0.4866972778382 2334 6252086
SGTC_874 0599-0792 117 µM 0.0326594249130231 0.489033878711903 no 1639 0.486973090422631 2336 765305
SGTC_452 diindolylmethane 8 µM 0.0325065727423396 0.489094718762024 no 1640 0.487034037255362 2339 3071 Inhibits expression of several cancer promoting factors.
SGTC_2193 5925765 200 µM 0.0317007062120731 0.489415483564304 no 1641 0.487355365847643 2329 877370
SGTC_1604 st002052 72.4 µM 0.0279881769313018 0.490893293267402 no 1642 0.488835790448126 2285 6254834 YHR062C RPP1
SGTC_2793 7325131 81.82 µM 0.0276881676829711 0.491012720703681 no 1643 0.488955430454026 2324 4176441
SGTC_2157 5649910 96.377 µM 0.0273194676220687 0.49115949362486 no 1644 0.489102464872929 2342 2858091
SGTC_2408 sulbentine 18.36 µM 0.026178075891474 0.491613868824966 no 1645 0.489557651396684 2248 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1914 st062367 72.6 µM 0.0260139160147167 0.491679219933006 no 1646 0.489623119416505 2344 978205
SGTC_2295 7971645 200 µM 0.0252825585377487 0.491970371851159 no 1647 0.489914792877798 2330 2978226 YKL099C UTP11
SGTC_1367 1812-0510 76.9 µM 0.0252781377374104 0.49197213177591 no 1648 0.489916555958488 2341 1142582 YDR527W RBA50
SGTC_268 camptothecin 39.6153 µM 0.0242484506547088 0.492382055352094 no 1649 0.490327215721377 2359 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1789 tunicamycin 25 nM 0.0229697272087702 0.492891132700315 no 1650 0.490837210381631 2349 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1648 st011736 69.8 µM 0.0224807164166321 0.493085817711687 no 1651 0.491032247091782 2356 2855514
SGTC_2971 9092186 9.93 µM 0.0220306912822004 0.493264983206547 no 1652 0.491211736686065 2349 25236400
SGTC_3140 9094243 49.47 µM 0.0219832933766727 0.493283853497164 no 1653 0.491230641136241 2376 19291112
SGTC_1354 1498-1681 81 µM 0.0217127641501352 0.493391558228933 no 1654 0.491338540927142 2340 5754243
SGTC_1526 st051518 75 µM 0.0215821761346136 0.493443548892327 no 1655 0.491390625802557 2255 673993
SGTC_2506 ethyl hematommate 54.16 µM 0.0209157392073852 0.493708877390248 no 1656 0.491656435649365 2286 3940691 An allergen.
SGTC_1616 st002734 56.1 µM 0.0206418392796685 0.493817925967402 no 1657 0.491765682324175 2328 4026101
SGTC_1321 1326-2144 215 µM 0.0202514352241852 0.493973359469307 no 1658 0.491921398454226 2352 3513030
SGTC_1573 oleylamine 1.06 µM 0.0194736225540962 0.494283036587552 no 1659 0.492231639602524 2351 5356789 An amine of the fatty acid oleic acid.
SGTC_408 cantharidin 100 µM 0.0193243770697424 0.494342457350653 no 1660 0.492291168734246 2333 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2319 6033012 152.6 µM 0.0190382077863983 0.49445639345732 no 1661 0.492405312760355 2364 847246
SGTC_262 fenpropimorph 62.5 µM 0.01851634241146 0.49466417131397 no 1662 0.49261347022079 2372 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_292 k038-0015 474 µM 0.0183514727880203 0.494729813560135 no 1663 0.492679232510003 2353 46368540
SGTC_1951 sophoraflavanone G 9.2 µM 0.0178975186893972 0.494910554479866 no 1664 0.492860304248515 2375 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3332 9141069 11.198 µM 0.0176255338028881 0.495018845223296 no 1665 0.492968793405054 2371 17332883
SGTC_2890 9046729 58.44 µM 0.0156960730070482 0.495787069834333 no 1666 0.493738429949343 2355 903329
SGTC_608 k048-0125 159 µM 0.0146942950291491 0.49618593916369 no 1667 0.494138035387759 2382 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2885 9057732 51.95 µM 0.013566143646847 0.496635130050272 no 1668 0.494588057720321 2355 6471414
SGTC_2505 galangin 7.89 µM 0.0115239523691977 0.497448270489833 no 1669 0.495402709917306 2373 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1632 st005650 90 µM 0.0106904261603961 0.497780159323145 no 1670 0.495735218242844 2370 2759605
SGTC_472 calcifediol 10 µM 0.0101612375784885 0.497990869503456 no 1671 0.495946322466397 2353 5283731 A vitamin D metabolite.
SGTC_2726 cimetidine 79.27 µM 0.00947829208849543 0.498262802810785 no 1672 0.496218765156432 2394 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1497 4476-2978 41.3 µM 0.00919869233607277 0.498374133290975 no 1673 0.496330304455266 2373 1528379
SGTC_2001 4023502 57.655 µM 0.00914607803655442 0.498395083163822 no 1674 0.496351293640938 2378 108941 YCR052W RSC6
SGTC_2840 9008771 71.43 µM 0.00899566489268334 0.498454974439417 no 1675 0.496411297334876 2383 2992978
SGTC_1492 4158-0558 28.5 µM 0.00814624312465514 0.498793196514293 no 1676 0.496750155135161 2393 3967268
SGTC_2141 5621638 7.665 µM 0.00702098645841481 0.499241251601727 no 1677 0.497199054663382 2390 2856238
SGTC_1686 st019653 115.5 µM 0.006604564428793 0.499407062941805 no 1678 0.497365179161 2396 97252
SGTC_1852 st056254 31.4 µM 0.00362633883923606 0.499407062941805 no 1679 0.498553303284725 2382 442583
SGTC_873 0591-4978 488 µM 0.00362621357237514 0.499407013062904 no 1680 0.498553353258644 2394 3305145
SGTC_2966 9084041 48.03 µM 0.00213155398357746 0.498811868693279 no 1681 0.499149633636936 2401 17741380
SGTC_379 3970-0972 5.9 µM 0.00200011039624022 0.498759530521268 no 1682 0.49920207192948 2398 2898042 YBL034C STU1
SGTC_73 0327-0325 16.231 µM 0.00177413380060961 0.498669551272024 no 1683 0.499292223387141 2401 53298
SGTC_740 k014-0057 261 µM 0.00176202246384766 0.498664728787804 no 1684 0.499297055103896 2401 4012779
SGTC_1843 st055809 45.5 µM 0.00119729857452096 0.49843986762421 no 1685 0.49952234709048 2395 16413835
SGTC_95 0471-0001 561.058 µM 0.000690926396087473 0.498238241302795 no 1686 0.499724360269886 2405 4015405
SGTC_1182 1222-0449 220 µM 0 0.497963130266196 no 1687 0.5 2405 658318
SGTC_884 0851-0618 334 µM -0.000779523620013142 0.49765274301766 no 1688 0.499689015100901 2408 9642473
SGTC_1162 k048-0130 20.1 µM -0.00146295436471891 0.497380618765488 no 1689 0.499416365857802 2406 6797406
SGTC_432 NS 1619 61.3 µM -0.00257930218342301 0.496936120933218 no 1690 0.498971008446047 2444 4552 A K+/calcium channel activator.
SGTC_928 2764-0428 58.7 µM -0.00265841688026153 0.496904619857327 no 1691 0.498939446356718 2428 662578
SGTC_1570 verbenone 133 µM -0.00326537173299786 0.496662949476213 no 1692 0.498697307469506 2411 29025 A natural terpanoid with antifungal properties.
SGTC_1158 4092-0494 91.8 µM -0.00353302315878102 0.496556379459001 no 1693 0.498590530616551 2431 1148199
SGTC_495 decylubiquinone 155 µM -0.00388257878913512 0.496417198245688 no 1694 0.498451079055539 2421 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1024 4507-0395 26 µM -0.00407592532887974 0.496340214388026 no 1695 0.498373945556871 2446 4201836
SGTC_4 0960-0234 25.671 µM -0.0045286907381044 0.496159939510644 no 1696 0.498193319965255 2359 6821112
SGTC_2458 5808907 16.39 µM -0.00494223268769881 0.49599528268635 no 1697 0.498028342447806 2418 2731747
SGTC_1361 1608-0041 5.61 µM -0.00498654559574913 0.49597763899581 no 1698 0.498010664373059 2412 X1361
SGTC_1656 st012921 11 µM -0.00578516961624563 0.495659659101401 no 1699 0.497692064114532 2420 6732821
SGTC_3118 9124250 49.47 µM -0.00721872027097673 0.495088884065523 no 1700 0.497120172284805 2443 1504786
SGTC_2109 5483026 200 µM -0.00733201688326107 0.495043774891938 no 1701 0.497074974672155 2422 759335
SGTC_2444 5485484 36.41 µM -0.00853644209717721 0.494564235670888 no 1702 0.496594493683641 2427 6790631
SGTC_2741 miltefosine 3.04 µM -0.00902964739981492 0.494367869303677 no 1703 0.496397740826583 2423 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3239 9133757 49.47 µM -0.00936789955214702 0.494233197274976 no 1704 0.496262803451372 2420 17036923
SGTC_1234 0326-0494 15.5 µM -0.00962324084113307 0.494131535889561 no 1705 0.496160941607874 2428 1547813
SGTC_1337 1486-1011 40.3 µM -0.0100851268836768 0.493947641906802 no 1706 0.495976684684759 2424 X1337
SGTC_3184 9108758 49.47 µM -0.0103815146845992 0.493829639593776 no 1707 0.495858449251029 2421 902885
SGTC_2488 5268135 45.7 µM -0.0106111966015587 0.493738195588734 no 1708 0.495766824470961 2430 1270356 YLR208W SEC13
SGTC_2748 diazoxide 86.69 µM -0.0114379646646324 0.493409034502142 no 1709 0.495437011787461 2438 3019 A potassium channel activatior.
SGTC_3044 9093193 49.47 µM -0.0115501261063886 0.493364380019234 no 1710 0.495392268801802 2441 25236277
SGTC_611 3453-1652 23.7 µM -0.0116158998666417 0.493338193757068 no 1711 0.495366030628097 2432 1560575
SGTC_109 0132-0036 33.701 µM -0.0122691415463162 0.493078122657047 no 1712 0.495105443491014 2422 67274 A color developer.
SGTC_2801 7907800 81.82 µM -0.0131563907306162 0.492724892318707 no 1713 0.494751510891216 2437 6620925
SGTC_3005 9076496 71.4286 µM -0.0136148658285359 0.492542367106077 no 1714 0.494568622177027 2429 21368410
SGTC_634 1611-4317 11.2 µM -0.0141239946196887 0.492339677796146 no 1715 0.494365528712839 2431 2843522
SGTC_3062 9077494 49.47 µM -0.0146400043309062 0.492134251140851 no 1716 0.494159691913159 2423 16459633
SGTC_2992 9074591 71.4286 µM -0.0155376821440561 0.491776885058532 no 1717 0.493801611056363 2427 17741321
SGTC_972 1319-0219 195 µM -0.0165528988890439 0.491372734624287 no 1718 0.493396650322603 2446 23903702
SGTC_2129 girgensonine 121.053 µM -0.0168932544850081 0.491237243488048 no 1719 0.493260887070848 2457 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2591 skatole 100 µM -0.0169718728415874 0.491205946685945 no 1720 0.493229527380318 2448 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1377 2944-0135 198 µM -0.0171943833918509 0.49111736882907 no 1721 0.493140771466075 2444 1894137
SGTC_995 3931-2021 34.6 µM -0.017882102684193 0.490843601672716 no 1722 0.49286645336071 2446 730143
SGTC_517 1365-0151 113 µM -0.0180267183293941 0.490786033650575 no 1723 0.492808769363762 2490 768657
SGTC_671 0560-0003 407 µM -0.0203675025273218 0.489854251105904 no 1724 0.491875103848317 2469 3238678
SGTC_699 0375-0592 111 µM -0.0204801333193514 0.489809418167774 no 1725 0.49183018003389 2436 762578
SGTC_2795 7780010 54.55 µM -0.0216673950198229 0.489336833939735 no 1726 0.491356636334368 2483 953673
SGTC_3034 9090421 49.47 µM -0.0217525878348945 0.489302923887151 no 1727 0.491322657326959 2428 17173761
SGTC_1603 st002045 67.8 µM -0.0221168392239222 0.489157938547783 no 1728 0.49117737700167 2445 5887985
SGTC_1082 camptothecin 424.86 nM -0.022492289557072 0.489008497119794 no 1729 0.491027631243876 2441 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_670 4204-0025 119 µM -0.0228227750180968 0.488876954447728 no 1730 0.490895820458798 2474 719039
SGTC_2464 5717415 7.67 µM -0.0237302655207121 0.488515753520565 no 1731 0.490533882202362 2457 5285744
SGTC_451 chloral hydrate 100 µM -0.0247842747490623 0.488096246801738 no 1732 0.490113517069494 2478 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2179 6298986 200 µM -0.0248455448075015 0.488071861076936 no 1733 0.490089081377324 2474 738374
SGTC_2759 disulfiram 3.38 µM -0.0253231944911432 0.487881756155829 no 1734 0.489898586666613 2468 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_654 1124-0271 80.9 µM -0.0263510888239872 0.487472662858933 no 1735 0.489488653025553 2471 5403748
SGTC_1314 1222-0010 41.1 µM -0.0264460952788476 0.48743485174807 no 1736 0.489450764138223 2472 3526027
SGTC_2627 acetyl isogambogic acid 100 µM -0.0272576412205753 0.487111873556784 no 1737 0.48912712085659 2501 6857789 A caspase activator and apoptosis inducer.
SGTC_968 1309-0633 340 µM -0.0278094004197951 0.486892289831432 no 1738 0.488907084206336 2447 3761976
SGTC_1362 1611-0397 101 µM -0.0281218664905159 0.486767939401268 no 1739 0.488782477015757 2459 27816
SGTC_3168 9103419 49.47 µM -0.029345791103022 0.486280873252898 no 1740 0.488294403296714 2449 16649256
SGTC_522 1273-0010 11.6 µM -0.0293760279015069 0.486268840642846 no 1741 0.488282345757674 2621 5705015
SGTC_1606 st000094 49.2 µM -0.0293979365162776 0.486260122207185 no 1742 0.488273609258149 2450 1242210
SGTC_784 4579-0127 173 µM -0.0300610549232329 0.485996240317662 no 1743 0.488009180176255 2539 1948547
SGTC_2701 st077767 14.721 µM -0.0302584590055424 0.485917686352397 no 1744 0.487930463150702 2479 5721188
SGTC_2606 farnesol 9.78 µM -0.0306203221967999 0.485773689796284 no 1745 0.487786167489304 2470 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2514 salinomycin 42.74 µM -0.0307922312472285 0.48570528251682 no 1746 0.48771761802521 2484 23682228 A polyether potassium ionophore.
SGTC_1067 clotrimazole 1.36 µM -0.0323027497209887 0.485104224508388 no 1747 0.487115308195189 2477 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2957 9076800 11.52 µM -0.0324112138817829 0.485061066274288 no 1748 0.487072059901413 2496 16459615
SGTC_2260 7964312 200 µM -0.0330910223603014 0.484790572327159 no 1749 0.486801000974709 2548 231951
SGTC_406 estrone 100 µM -0.0333022896552375 0.484706511064003 no 1750 0.486716763946599 2475 5870 A steroid.
SGTC_1268 0828-0275 2.46 µM -0.0343737045008246 0.484280215748329 no 1751 0.486289575922577 2521 745337
SGTC_297 0986-0032 24 µM -0.0353064849188592 0.483909095012422 no 1752 0.485917676169422 2459 2847425
SGTC_195 4234-0266 16.654 µM -0.0390980582914271 0.482400707315305 no 1753 0.484406104523064 2488 2303354
SGTC_1777 st045864 34.765 µM -0.039105320082363 0.482397818618497 no 1754 0.484403209701482 2479 4691462
SGTC_1774 st048371 48.465 µM -0.0413657889664552 0.481498663352328 no 1755 0.483502142945462 2484 4242727
SGTC_958 1222-0007 33 µM -0.0413672370881522 0.481498087357154 no 1756 0.48350156572257 2518 7312461
SGTC_1700 st030840 7.9285 µM -0.0421476082428806 0.481187697810334 no 1757 0.483190513988389 2534 5499307
SGTC_3223 9129970 49.47 µM -0.0422802870706101 0.481134926459393 no 1758 0.483137629935481 2499 17248386
SGTC_2347 9049783 174.81 µM -0.0426187854920856 0.481000294428681 no 1759 0.483002710218905 2518 6467988 YPL169C MEX67
SGTC_2958 9077254 16.72 µM -0.0428647918594651 0.480902450909408 no 1760 0.482904657483209 2531 16457351
SGTC_856 0433-0016 11.3 µM -0.0437275714127806 0.480559308810024 no 1761 0.482560780711183 2531 3911780
SGTC_1103 duloxetine 36.1 µM -0.0441255513401948 0.480401030264947 no 1762 0.482402162796303 2578 60835 A selective serotonin reuptake inhibitor.
SGTC_969 1313-0238 134 µM -0.0446146984303726 0.480206498332936 no 1763 0.482207213336396 2494 5212874
SGTC_1349 flufenamic acid 69 µM -0.0457513549224478 0.479754472664756 no 1764 0.481754215662565 2490 3371 A non-steroidal anti-inflammatory.
SGTC_1916 st067606 49.2 µM -0.0480938290687351 0.47882300007089 no 1765 0.480820732103117 2550 19590279
SGTC_2973 9094665 17.96 µM -0.0481798373319364 0.478788801504913 no 1766 0.480786459500944 2536 25237061 YIL048W NEO1
SGTC_918 glabranin 770.725 nM -0.0483941246709688 0.47870359735169 no 1767 0.480701070826968 2522 124049 Also referred to as licorice root.
SGTC_1189 1431-2119 7.28 µM -0.0490329662782571 0.478449589263809 no 1768 0.480446512118037 2486 3107275
SGTC_2442 5158906 48.48 µM -0.0491978946946946 0.478384013938573 no 1769 0.480380794513505 2558 1893835
SGTC_372 0155-0182 15.9 µM -0.0496509969911893 0.478203864068442 no 1770 0.480200253496966 2499 771486
SGTC_362 0310-0100 9.03 µM -0.0502393290085577 0.477969954587338 no 1771 0.479965835546165 2536 790235
SGTC_304 1310-0298 97 µM -0.0505272294710794 0.477855493667635 no 1772 0.479851125566148 2507 1550234
SGTC_1727 st034309 9.9045 µM -0.050765262414099 0.477760860014327 no 1773 0.479756285873214 2585 870305
SGTC_2206 7254556 146.969 µM -0.0510866848244785 0.47763307558803 no 1774 0.479628223054676 2485 4398905
SGTC_2634 4'-methoxyflavone 100 µM -0.051517605224592 0.477461762842364 no 1775 0.479456536769066 2520 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2983 9022671 12.99 µM -0.0529829597576551 0.476879241339786 no 1776 0.478872742392548 2637 6405161
SGTC_332 4112-0506 40.9 µM -0.0558858580578226 0.4757254010008 no 1777 0.477716368428736 2510 2790355
SGTC_2484 5809818 12.04 µM -0.0576360803654666 0.475029822585702 no 1778 0.477019254727063 2544 2870548
SGTC_337 1315-0038 354 µM -0.0582052533167471 0.474803636519364 no 1779 0.476792568138578 2532 1626437
SGTC_1183 1254-0324 198 µM -0.059179020864339 0.474416685752079 no 1780 0.476404759638377 2565 5799357
SGTC_632 0781-2353 4.65 µM -0.0597130223150936 0.474204497209603 no 1781 0.47619209996806 2575 6811515 YHR007C ERG11
SGTC_489 paxilline 115 µM -0.0617331994274676 0.473401834943695 no 1782 0.475387650530269 2558 105008 A toxic potassium channel blocker.
SGTC_1899 st063254 59.6 µM -0.0622897857683233 0.473180709379347 no 1783 0.475166031229193 2505 3093813
SGTC_151 3013-0144 2.285 µM -0.0623102344535852 0.473172585501041 no 1784 0.475157889200199 2723 906558 YHR107C CDC12
SGTC_574 1315-0397 40 µM -0.0623497266980188 0.473156896006202 no 1785 0.475142164648982 2530 6794277
SGTC_851 0394-0702 453 µM -0.0623608283419071 0.473152485548126 no 1786 0.4751377443357 2521 762646
SGTC_1835 st008666 49.2 µM -0.0630562403730315 0.472876219027169 no 1787 0.474860860019746 2535 690455
SGTC_805 3852-0218 479 µM -0.0645666272635824 0.472276232348535 no 1788 0.474259528414323 2538 6615355
SGTC_2090 5301565 104.445 µM -0.0646375473442665 0.472248061563516 no 1789 0.47423129437352 2535 2056344
SGTC_2526 patulin 37.61 µM -0.0649167175527166 0.472137171275503 no 1790 0.474120154993769 2593 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1357 1503-1303 39.5 µM -0.0664738097488586 0.471518712463968 no 1791 0.473500304186019 2522 292895
SGTC_205 1486-1330 71.903 µM -0.066900447273735 0.471349268951447 no 1792 0.473330478482525 2518 4118834
SGTC_950 1165-0508 94.1 µM -0.0669915667879926 0.471313080563524 no 1793 0.473294208423856 2569 6148369
SGTC_2380 9035439 200 µM -0.0673431802611031 0.47117343844303 no 1794 0.473154251006005 2661 6462575
SGTC_3177 9107506 49.47 µM -0.0693778725433414 0.470365437305738 no 1795 0.472344420812451 2543 8897194
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0697277825941428 0.470226495955677 no 1796 0.472205164140999 2505 6708630 An antioxidant.
SGTC_2121 5257820 149.641 µM -0.0699678465887618 0.470131174080216 no 1797 0.472109625800525 2545 791256
SGTC_2769 toremifene 3.73 µM -0.0716902395745168 0.469447316422219 no 1798 0.471424211933806 2630 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3092 9117248 49.47 µM -0.0732203297554578 0.46883988605342 no 1799 0.470815394501473 2525 17141857
SGTC_1410 3909-8106 77.9 µM -0.0733896027593098 0.468772690808131 no 1800 0.470748045540495 2571 1039210
SGTC_1135 dihydrocapsaicin 536.708 nM -0.0738544175352115 0.468588180775299 no 1801 0.47056311314057 2512 107982 A Capsaicinoid.
SGTC_3019 9081971 49.47 µM -0.0740420307144619 0.468513708903177 no 1802 0.470488470675555 2576 16451803
SGTC_1588 farnesol 29.9 µM -0.0746036733836269 0.468290774972555 no 1803 0.470265025666733 2540 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2674 ligustilide 100 µM -0.0768036611838548 0.467417625890886 no 1804 0.469389869070344 2605 5319022 A signalling regulator.
SGTC_2138 5575593 77.673 µM -0.077010229451249 0.46733564937895 no 1805 0.469307703605638 2543 762213
SGTC_41 0478-0632 82.643 µM -0.0788689249472316 0.466598089746631 no 1806 0.468568440261652 2528 3750424
SGTC_1883 5-benzylidenerhodanine 20 µM -0.0790045128733333 0.466544290780869 no 1807 0.468514516766033 2580 1273210
SGTC_2532 xanthone 78.9 µM -0.0798809541288185 0.466196548697715 no 1808 0.468165968909773 2599 7020 An insecticide.
SGTC_1399 3562-5772 25 µM -0.0807711935571127 0.46584335838803 no 1809 0.467811958704201 2539 23847490
SGTC_1732 st034308 51.822 µM -0.0808381834551188 0.465816782147644 no 1810 0.467785320708677 2521 830119
SGTC_2696 st077691 74.316 µM -0.0821949302660087 0.465278566361293 no 1811 0.467245852433701 2657 757133
SGTC_3013 9080133 71.4286 µM -0.0822572783433809 0.465253834658552 no 1812 0.467221063093353 2671 17050193
SGTC_1371 2421-0008 32.7 µM -0.0828456652281756 0.465020444998137 no 1813 0.46698712915083 2607 2827552
SGTC_1031 k035-0009 16 µM -0.0828756291974797 0.465008559805344 no 1814 0.466975216223271 2671 5180959
SGTC_2772 vinpocetine 57.06 µM -0.0845465694005497 0.464345831958292 no 1815 0.466310939164229 2623 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2733 amorolfine 100 µM -0.0849106009722122 0.464201462913298 no 1816 0.466166231934791 2586 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1687 st020778 55.3625 µM -0.0853319733944558 0.464034359299106 no 1817 0.465998736566526 2575 4259299
SGTC_785 1270-0111 65.3 µM -0.0862371299641136 0.46367542294944 no 1818 0.465638957595998 2537 6741994
SGTC_1792 st045773 43.6 µM -0.0863623797794281 0.463625757939855 no 1819 0.465589175873043 2562 2919270
SGTC_249 wiskostatin 11.211 µM -0.0866214976334633 0.463523012357513 no 1820 0.465486188743001 2538 2775510 A n-wasp and actin depolymerizer.
SGTC_1180 1193-0155 285 µM -0.0872412087680831 0.463277293970185 no 1821 0.465239892173131 2640 2921347
SGTC_2404 5161160 200 µM -0.0872651969813177 0.463267782811555 no 1822 0.465230358619848 2552 2831543
SGTC_1498 4478-3555 97.6 µM -0.0873913052423955 0.463217782114257 no 1823 0.46518024017468 2558 3437919
SGTC_3045 9092950 49.47 µM -0.0873913157045508 0.463217777966138 no 1824 0.465180236016792 2561 44120432
SGTC_1446 4239-0190 62 µM -0.0886580915166731 0.462715546061312 no 1825 0.464676819724327 2578 1340085
SGTC_1893 st059353 36.1 µM -0.0890164316299302 0.462573487601044 no 1826 0.46453442570423 2617 3112488
SGTC_1114 scopoletin 1.73284 µM -0.0914565647203323 0.461606261990032 no 1827 0.463564908936307 2560 5280460 A coumarin with genotoxic properties.
SGTC_2371 9071574 200 µM -0.0918197369891795 0.461462326195655 no 1828 0.463420631227241 2557 45596039
SGTC_2022 5136654 200 µM -0.0919075817840012 0.461427511491089 no 1829 0.46338573378415 2677 1713771
SGTC_3293 9120939 62.045 µM -0.0920485352703944 0.461371649334125 no 1830 0.463329738838155 2647 934087
SGTC_2902 5787006 60.46 µM -0.0922041667731516 0.461309970926147 no 1831 0.463267913771926 2585 591003
SGTC_2043 5101342 149 µM -0.092331664886168 0.461259442771019 no 1832 0.463217265437478 2600 678451
SGTC_2946 9065502 71.43 µM -0.0923448318908962 0.461254224655229 no 1833 0.463212034908849 2546 16489101
SGTC_1596 piperlongumine 63 µM -0.092775296857025 0.461083634028058 no 1834 0.463041038301294 2651 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2807 7945238 51.95 µM -0.0930745141602639 0.460965060261966 no 1835 0.462922182141571 2657 17148797
SGTC_3280 9140961 49.47 µM -0.093405254242159 0.460833998694678 no 1836 0.462790808243683 2560 4901226
SGTC_2397 5161689 200 µM -0.0950851900984927 0.460168360581913 no 1837 0.462123580681637 2680 2259942
SGTC_271 rotenone 740 µM -0.0953975268217417 0.460044616185018 no 1838 0.46199954021557 2704 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1833 st055984 71 µM -0.0975201353539111 0.459203765002559 no 1839 0.461156672370107 2620 676288
SGTC_1913 st060213 96.1 µM -0.0992648066887657 0.458512766505804 no 1840 0.46046401028255 2641 688959
SGTC_454 lyso-paf C-16 6.67 µM -0.101053198295399 0.457804582174115 no 1841 0.459754115068641 2636 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2691 st077356 60.2 µM -0.101573452177211 0.457598592139978 no 1842 0.459547626265805 2706 2839272
SGTC_855 0428-0020 25 µM -0.102249748587029 0.457330835448126 no 1843 0.459279220492004 2608 6812414
SGTC_2431 5490079 200 µM -0.102702786614559 0.457151481187257 no 1844 0.459099430971965 2626 5722345
SGTC_2310 7668677 200 µM -0.103684689812461 0.456762783288221 no 1845 0.458709788460975 2702 2197143
SGTC_1240 0356-0016 42.1 µM -0.104122074842367 0.456589652588163 no 1846 0.458536236440381 2660 4305613
SGTC_1432 4049-0298 68.4 µM -0.104228730578264 0.456547436154331 no 1847 0.458493917217055 2649 741646
SGTC_1112 tnp00069 1.16933 µM -0.105917258045041 0.455879149496 no 1848 0.457824000575601 2727 145826
SGTC_2799 7812892 81.82 µM -0.105951612727415 0.455865553863314 no 1849 0.457810371727399 2676 20205235
SGTC_1219 1469-0211 33.1 µM -0.1064224160681 0.455679241846057 no 1850 0.457623604309579 2600 6822282
SGTC_291 SEC14.278 35.5 µM -0.106803788891654 0.45552832750257 no 1851 0.457472320785346 2612 1068044
SGTC_1762 st045503 25.4615 µM -0.106956695037779 0.455467822289776 no 1852 0.457411667483074 2656 4645554
SGTC_2669 eugenol 100 µM -0.107219048389481 0.455364011045478 no 1853 0.457307602054361 2583 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.107255304189415 0.455349665138186 no 1854 0.457293221010693 2694 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2711 st079103 59.1 µM -0.107345686394101 0.455313902431539 no 1855 0.457257370702436 2694 54693780
SGTC_1855 st056195 39.6 µM -0.107679463444953 0.455181835649363 no 1856 0.457124980287916 2653 4028379
SGTC_448 monastrol 171 µM -0.107842642022073 0.455117271988795 no 1857 0.457060258337422 2627 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2026 5148700 152 µM -0.107912004277885 0.455089828297082 no 1858 0.457032747347363 2600 79838
SGTC_3052 9092717 49.47 µM -0.108432239222063 0.454884000318568 no 1859 0.45682641434562 2731 25237534
SGTC_2883 9059145 45.46 µM -0.108789902734714 0.454742499819172 no 1860 0.456684566366469 2565 16476510
SGTC_1756 st041558 35.5 µM -0.108970943436351 0.454670877844217 no 1861 0.45661276842042 2676 3955792
SGTC_281 1672-3440 14.9 µM -0.11063217707611 0.454013742050626 no 1862 0.455954015242702 2681 6833000
SGTC_1759 st043059 70 µM -0.111346122888666 0.453731364382192 no 1863 0.455670940996645 2628 669426
SGTC_2564 betulinic acid 100 µM -0.11205132563178 0.453452467705958 no 1864 0.455391355402992 2700 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_898 1000-0849 28.3 µM -0.112596707840444 0.453236793290501 no 1865 0.455175147607511 2574 6751807
SGTC_1165 k072-0275 30.3 µM -0.112982464375335 0.453084252056322 no 1866 0.455022228794422 2618 6153523 YGL055W OLE1
SGTC_272 doxorubicin 8.13 µM -0.113243080265489 0.452981199599823 no 1867 0.45491892110073 2580 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1866 st057638 64 µM -0.113552180021012 0.452858979810754 no 1868 0.454796398438605 2631 688802
SGTC_1034 k072-0165 12.7 µM -0.113622448756773 0.452831195778378 no 1869 0.454768545529936 2642 5835461
SGTC_387 norethindrone acetate 66.7 µM -0.114065728556437 0.452655929698605 no 1870 0.454592844757227 2662 541197
SGTC_279 1273-0055 2.93 µM -0.114529626598488 0.452472521357871 no 1871 0.454408981140466 2644 2847562
SGTC_2435 5706476 10.6 µM -0.114908911430933 0.452322573522668 no 1872 0.454258660793219 2655 5725375
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.115045318944749 0.452268647345056 no 1873 0.454204600583077 2604 229346 A bile salt which induces apoptosis.
SGTC_790 1575-0012 79.1 µM -0.115217733379944 0.452200487759656 no 1874 0.454136271539132 2602 378741 YLR208W SEC13
SGTC_515 4092-1064 102 µM -0.11697538676227 0.451505725706215 no 1875 0.453439779037714 2688 717353
SGTC_2831 7999036 19.48 µM -0.11953642198561 0.45049367074362 no 1876 0.452425193158223 2872 2988270
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.119541938832523 0.45049149097325 no 1877 0.452423007923725 2697 688761
SGTC_1366 1683-0113 21.9 µM -0.119613914678723 0.450463052616272 no 1878 0.452394498273921 2619 708623
SGTC_2596 sinensetin 100 µM -0.119787640066731 0.450394413073611 no 1879 0.452325686617854 2671 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2875 9039966 71.43 µM -0.120670016803788 0.45004580571348 no 1880 0.451976204269995 2718 6463691
SGTC_847 0342-0274 5.54 µM -0.120851195839418 0.449974230679931 no 1881 0.451904449409607 2732 18097
SGTC_384 k007-0144 5.16 µM -0.12134775880583 0.449778071128294 no 1882 0.451707796713104 2695 6824886
SGTC_2316 5844804 197.44 µM -0.121696403407053 0.449640351778087 no 1883 0.451569730866253 2722 776813
SGTC_949 1165-0505 146 µM -0.122188440100183 0.449446000929472 no 1884 0.451374890658933 2636 6244267
SGTC_2270 7924575 90.91 µM -0.122599878508632 0.449283495114286 no 1885 0.451211975327312 2842 1262135
SGTC_985 1493-0307 8.71 µM -0.125167665331041 0.448269489705528 no 1886 0.450195407608852 2667 3278274
SGTC_801 0866-0028 10.1 µM -0.125185561156828 0.44826242391675 no 1887 0.450188323923063 2621 6849771
SGTC_2916 7875993 68.79 µM -0.125368133747614 0.448190339924238 no 1888 0.450116057314791 2645 1299250
SGTC_502 l-744,832 89.3 µM -0.125594763001918 0.44810086369516 no 1889 0.450026354324142 2677 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2891 9063876 19.48 µM -0.128630840603077 0.446902436491044 no 1890 0.448824880876905 2682 6472478
SGTC_2838 9002687 71.43 µM -0.129176283108305 0.446687185683409 no 1891 0.448609081149013 2614 6457060
SGTC_2709 st078560 56 µM -0.129570711442486 0.4465315401639 no 1892 0.44845303837362 2686 17250903
SGTC_3208 9114115 49.47 µM -0.131552799198475 0.445749512915791 no 1893 0.447669010862611 2717 650895
SGTC_1988 st071872 53.4 µM -0.132503947702341 0.445374314639564 no 1894 0.447292850371682 2630 16414116
SGTC_2421 5690543 90.72 µM -0.133635192778931 0.444928137630356 no 1895 0.446845526981066 2724 3397993
SGTC_2460 5552655 174.22 µM -0.134395882141278 0.444628151556729 no 1896 0.446544768835443 2758 5401989
SGTC_1464 k208-0027 110 µM -0.135760410162628 0.444090114757852 no 1897 0.44600534466813 2764 X1464
SGTC_579 4491-1009 110 µM -0.13703141176697 0.443589048310596 no 1898 0.445502983152117 2644 1271041
SGTC_2273 7815444 169.05 µM -0.137745686808743 0.443307499477088 no 1899 0.445220705338705 2757 2824616
SGTC_24 0417-1663 219 µM -0.1379072522941 0.443243818485875 no 1900 0.445156859338275 2709 4329390
SGTC_1303 1160-0052 261 µM -0.139019273096186 0.442805555647894 no 1901 0.444717459601784 2660 3562476
SGTC_939 1165-0479 45.3 µM -0.139142994744245 0.442756799544448 no 1902 0.444668576882073 2667 1377347
SGTC_598 3937-0236 20.2 µM -0.140166742362439 0.442353395437133 no 1903 0.444264124102695 2720 1379313
SGTC_664 1222-0054 14.9 µM -0.140208240358419 0.442337044557076 no 1904 0.444247730677744 2688 6813991
SGTC_1461 k072-0203 53.8 µM -0.141364062434671 0.441881671576187 no 1905 0.443791171572644 2642 5418714
SGTC_3320 9137005 35.139 µM -0.14202128064081 0.441622773707586 no 1906 0.443531598272142 2718 4908713
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.142960932850444 0.441252659999763 no 1907 0.443160517634897 2801 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_367 0335-0881 7.1 µM -0.14419620259366 0.440766185453247 no 1908 0.442672769750147 2791 23828853
SGTC_2143 5623677 140.463 µM -0.144612905749805 0.440602099332551 no 1909 0.44250825351905 2642 5375313
SGTC_2443 5493264 126.67 µM -0.144729291875658 0.440556271531935 no 1910 0.442462305536738 2790 5340055
SGTC_2097 5376186 200 µM -0.145450400664991 0.440272347987034 no 1911 0.442177636871319 2723 742755
SGTC_2843 9000894 45.46 µM -0.145660735423262 0.440189538258106 no 1912 0.442094609643351 2637 2242070
SGTC_3066 9117245 49.47 µM -0.145947841733848 0.440076507451332 no 1913 0.441981281834142 2722 17176980
SGTC_1932 st074806 40.9 µM -0.146554817025307 0.439837563597435 no 1914 0.441741709639524 2904 17251235
SGTC_1250 0485-0349 40.2 µM -0.147122501001037 0.439614107118746 no 1915 0.441517664949522 2703 6842794 YDL195W SEC31
SGTC_1912 st060209 90.8 µM -0.147346401680438 0.439525978760901 no 1916 0.441429304450078 2750 688787
SGTC_2581 avocatin a 64 µM -0.147816122781659 0.439341104075302 no 1917 0.441243942488938 2729 6710728 A skin care supplement.
SGTC_567 1080-0542 68.4 µM -0.147995897165136 0.439270351262037 no 1918 0.441173003087541 2666 5950415
SGTC_2879 9041815 71.43 µM -0.1487689622644 0.438966122428424 no 1919 0.44086797128825 2666 4942971
SGTC_74 000s-0487 160.283 µM -0.148908932784034 0.438911042860052 no 1920 0.440812746231538 2647 677548
SGTC_371 0195-0006 7.36 µM -0.149192732873512 0.43879936878666 no 1921 0.440700777072444 2638 3928593
SGTC_3097 9117246 49.47 µM -0.150489399425724 0.438289198374993 no 1922 0.440189256765468 2660 16423892
SGTC_907 3448-6986 75.5 µM -0.150559438108524 0.438261644730856 no 1923 0.440161630129819 2782 590582
SGTC_2365 9042475 200 µM -0.152638700229697 0.437443787253307 no 1924 0.439341602108322 2755 6464479
SGTC_57 miconazole 162.5 nM -0.153153997800795 0.437241141161375 no 1925 0.439138417015489 2639 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3259 9138485 49.47 µM -0.153655372117319 0.437043986334749 no 1926 0.438940737340259 2895 17646153
SGTC_2874 9043904 71.43 µM -0.154421488252246 0.436742757609928 no 1927 0.438638705846968 2762 4463428
SGTC_229 benomyl 22.8748 µM -0.157077037222081 0.435698908943995 no 1928 0.437592067278698 2750 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2004 4023728 41.89 µM -0.157446996953398 0.435553519784643 no 1929 0.437446288544105 2756 360084 YDR527W RBA50
SGTC_1722 st034304 3.6505 µM -0.158598478587468 0.435101058943961 no 1930 0.436992613767765 2724 4036148 YLR033W RSC58
SGTC_831 k061-1017 217 µM -0.159636525154598 0.434693243849966 no 1931 0.436583702510166 2756 1240153
SGTC_570 0987-0065 62.6 µM -0.161209679990954 0.434075334498358 no 1932 0.435964128654333 2669 3104428
SGTC_3273 9137859 49.47 µM -0.163205603282812 0.433291600615116 no 1933 0.435178277289821 2694 2377234
SGTC_1200 1643-0193 18.4 µM -0.165232335431768 0.432496037472213 no 1934 0.434380557526955 2677 5403974
SGTC_347 4534-1311 26.2 µM -0.165476980150486 0.43240002431884 no 1935 0.434284283611616 2678 2862016
SGTC_1398 3558-0053 112 µM -0.166201129195402 0.432115848534923 no 1936 0.433999335418883 2694 4532369
SGTC_2934 9036370 36.88 µM -0.166685842572024 0.431925653431933 no 1937 0.433808622838393 2806 6462800
SGTC_2816 7982706 58.44 µM -0.169504171296458 0.430820092542267 no 1938 0.432700045808501 2813 2981853
SGTC_2288 7946289 167.31 µM -0.170820385622397 0.430303959217599 no 1939 0.432182499629224 2847 1246052
SGTC_2341 7987486 176.74 µM -0.170830850657949 0.430299855989804 no 1940 0.432178385157186 2815 1258686
SGTC_1715 st032160 10.2275 µM -0.171260272683168 0.430131490731861 no 1941 0.432009558355994 2804 5289825
SGTC_2685 mycophenolic acid 18.85 µM -0.171421710421583 0.430068198458224 no 1942 0.431946092494585 2775 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.175421754638451 0.428500543931851 no 1943 0.430374123945626 2906 94937 An inhibitor of serotonin biosynthesis.
SGTC_3330 9141424 71.43 µM -0.176911527548495 0.427916974910817 no 1944 0.429788941885661 2849 27261020
SGTC_977 1348-1378 135 µM -0.177012074023924 0.427877594835248 no 1945 0.429749452820998 2708 X977
SGTC_1970 st070122 35.8 µM -0.177520934701965 0.42767830527034 no 1946 0.429549611429057 2881 102928
SGTC_1967 st070177 51.4 µM -0.177843332949299 0.427552051165017 no 1947 0.429423007497197 2886 5729214
SGTC_1739 st037196 92.5 µM -0.177955451170881 0.427508146380873 no 1948 0.429378981018835 2840 612214
SGTC_2743 auranofin 4.32 µM -0.17834573690349 0.427355319969526 no 1949 0.429225730836875 2754 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2327 6189656 200 µM -0.179537060534648 0.426888894091731 no 1950 0.42875800997896 2831 5349088
SGTC_804 1595-0054 20.9 µM -0.180256871843726 0.426607123753923 no 1951 0.428475456145424 2738 761523 Stimulates phospholipase C.
SGTC_1194 1488-0194 225 µM -0.180335733547644 0.426576255591738 no 1952 0.428444502096152 2693 1391452
SGTC_1579 chlormadinone acetate 49.4 µM -0.180925077506432 0.426345587978227 no 1953 0.428213192336048 2896 45114258 A steroidal progestin.
SGTC_3134 9127454 49.47 µM -0.181963392280118 0.425939255755715 no 1954 0.427805727480015 2726 24262820
SGTC_2151 5563267 85.4165 µM -0.182208413879158 0.425843380896861 no 1955 0.427709585102456 2771 5310824
SGTC_3299 9121982 43.1275 µM -0.182532861154367 0.42571643419569 no 1956 0.427582284023568 2759 17594604 YPL160W CDC60
SGTC_237 nikkomycin 200 µM -0.183875644103716 0.425191124630387 no 1957 0.427055506100018 2874 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2852 9023854 51.95 µM -0.184958124495955 0.42476774454754 no 1958 0.426630940311607 2893 19798528
SGTC_854 0422-0053 192 µM -0.185752994139728 0.424456910098353 no 1959 0.426319234063821 2748 3596728
SGTC_2181 6316240 54.2555 µM -0.186019690130189 0.424352628920162 no 1960 0.426214660164185 2811 12779990
SGTC_78 0336-0123 156.75 µM -0.187305311788333 0.423850010585064 no 1961 0.425710629243529 2690 6765896
SGTC_2777 climbazole 1.536 µM -0.18779025082634 0.42366045407844 no 1962 0.42552053925946 2774 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2808 7946468 45.46 µM -0.18781287228571 0.423651612068366 no 1963 0.425511672355059 2814 2970879
SGTC_3219 9131112 49.47 µM -0.188732918571236 0.423292027818678 no 1964 0.425151074965952 2776 17612988 YMR079W SEC14
SGTC_234 nsc-17383 10.7 µM -0.188846685966366 0.423247568223169 no 1965 0.4251064900033 2847 408974
SGTC_2298 7976326 193.81 µM -0.189177827659958 0.423118165658428 no 1966 0.424976722422952 2766 2235818
SGTC_326 k292-0812 17.5 µM -0.189877703856317 0.422844697427607 no 1967 0.424702482181135 2778 3579357
SGTC_2221 6807166 181.081 µM -0.190977804414433 0.422414921519098 no 1968 0.424271491303413 2776 674925
SGTC_327 1273-0057 3.96 µM -0.191390329015819 0.422253784455296 no 1969 0.424109898173866 2808 3108138
SGTC_1333 1482-0047 286 µM -0.192546971763051 0.421802055378875 no 1970 0.423656889018331 2800 3811116
SGTC_1790 st045711 43.5 µM -0.193743487150966 0.421334862223786 no 1971 0.423188369558359 2879 585119
SGTC_544 k015-0020 52.4 µM -0.194000182552436 0.421234646964112 no 1972 0.423087869481359 2777 3008304
SGTC_800 3448-7362 155 µM -0.19440957422966 0.421074828821345 no 1973 0.42292759689402 2818 15991913
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.195020848573212 0.420836224024641 no 1974 0.42268831309026 2775 688801
SGTC_1233 0325-0408 14.2 µM -0.195143035224401 0.420788533177624 no 1975 0.422640486451163 2845 12874
SGTC_1133 3473-0247 50 µM -0.195578888150164 0.420618424271208 no 1976 0.422469892979617 2832 711311
SGTC_2642 cholecalciferol 100 µM -0.197017085742594 0.420057215887813 no 1977 0.421907083667731 2852 9821465 A vitamin D precursor, similar to steriods.
SGTC_345 1362-0200 395 µM -0.19710667893376 0.420022260514692 no 1978 0.421872028462914 2776 1419823
SGTC_1986 st071812 45 µM -0.199030790922746 0.419271708267396 no 1979 0.42111932936575 2767 11838594
SGTC_44 0929-0055 61.211 µM -0.19924550523607 0.419187971269084 no 1980 0.421035352459687 2772 1379590
SGTC_3244 9134489 49.47 µM -0.200612148755607 0.418655076323383 no 1981 0.420500928930132 2835 16584271
SGTC_2355 9061122 103.12 µM -0.200811172059396 0.418577483645651 no 1982 0.420423113417518 2894 5302957
SGTC_3149 9097855 49.47 µM -0.201078507118029 0.418473263434643 no 1983 0.420318593795678 2912 25236625 YMR079W SEC14
SGTC_2762 leflunomide 42.06 µM -0.201328639267403 0.418375754936727 no 1984 0.42022080505924 2769 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2721 ifenprodil 61.44 µM -0.202385219688552 0.417963925790226 no 1985 0.419807791151754 2911 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1575 cyproterone acetate 48 µM -0.202510802198595 0.417914982777915 no 1986 0.419758707213376 2807 9880 An androgen receptor antagonist and liver toxin.
SGTC_1121 fusaric acid 630.51 nM -0.203090493119467 0.417689077521875 no 1987 0.419532151142352 2781 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3076 9116187 49.47 µM -0.203132997165668 0.417672514784606 no 1988 0.419515540666822 2880 27241210
SGTC_1489 4065-0444 182 µM -0.203585281934349 0.417496280055011 no 1989 0.41933879779241 2809 2877968
SGTC_3069 9117009 49.47 µM -0.205947664721396 0.416576037423225 no 1990 0.418415896179523 2817 41904981
SGTC_2534 helenine 20.12 µM -0.208434871352669 0.415607664841007 no 1991 0.417444715395571 2760 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_563 tetrahydrosecaminediol 614 µM -0.209266115285899 0.415284141065799 no 1992 0.417120251110538 2927 334274 A psychoactive constituent of the cannabis plant.
SGTC_673 1082-0474 110 µM -0.209583405652178 0.415160665399631 no 1993 0.416996416184856 2787 3098046
SGTC_630 4356-0227 183 µM -0.210165562655577 0.414934136910857 no 1994 0.416769228159448 2787 779312
SGTC_1346 1488-2224 62.4 µM -0.211090678636057 0.414574214694558 no 1995 0.416408256862956 2818 3722427
SGTC_2050 5263056 171 µM -0.21119601861608 0.414533236051895 no 1996 0.416367158687245 2921 763468 YGL055W OLE1
SGTC_2056 5235370 200 µM -0.211993265919032 0.414223126518589 no 1997 0.416056143974748 2819 5511916
SGTC_3265 9137266 49.47 µM -0.214636816457437 0.413195234185558 no 1998 0.415025243724399 2750 17224265
SGTC_2305 7443522 69.23 µM -0.215341272377221 0.412921420506081 no 1999 0.41475062681703 2796 5415886
SGTC_2463 5473429 200 µM -0.215760046792142 0.412758667913379 no 2000 0.414587396400308 2843 5399405
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.21623266896241 0.412575005929486 no 2001 0.41440319485381 2832 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1300 1094-0077 113 µM -0.217042592930871 0.412260312271399 no 2002 0.414087575823388 2802 5532636
SGTC_2359 9039622 200 µM -0.219686223041261 0.411233530830923 no 2003 0.41305776749435 2778 6463596
SGTC_1126 isoteolin 1.0172 µM -0.220269723838821 0.411006981744453 no 2004 0.412830548992558 2807 133323
SGTC_246 cycloheximide 667 µM -0.220968923807191 0.410735550578503 no 2005 0.41255831504893 2779 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_479 n-linoleoylglycine 10 µM -0.22155546900243 0.410507885236118 no 2006 0.412329975745026 2816 6433346 An anti-infammatory.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.222305489586709 0.410216811465402 no 2007 0.412038039474288 2802 16623 A steroid.
SGTC_636 0kpi-0074 126 µM -0.222516376836619 0.410134977616664 no 2008 0.411955962970653 2882 616434
SGTC_2812 7970281 58.44 µM -0.223033423499478 0.409934356551096 no 2009 0.41175474670955 2935 2233435
SGTC_1257 0669-0121 16 µM -0.223338960029724 0.409815815342446 no 2010 0.41163585360935 2895 4307855
SGTC_2382 9035899 200 µM -0.223974933883384 0.409569098431385 no 2011 0.411388403820592 2815 6462679
SGTC_832 4083-0019 164 µM -0.224183133239956 0.409488338259989 no 2012 0.411307403604361 2931 1990758
SGTC_2593 nobiletin 86.24 µM -0.224538504860095 0.40935049909577 no 2013 0.411169154573204 2881 72344 An anti-infammatory.
SGTC_568 1193-0097 7.48 µM -0.224578941801603 0.409334815395486 no 2014 0.411153424223987 2892 3646150
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.224948686205147 0.409191414635416 no 2015 0.411009596813706 2791 23665772 A membrane-active detergent.
SGTC_203 k066-0004 30.888 µM -0.224973919825437 0.409181628532916 no 2016 0.410999781587085 2779 6795412
SGTC_1714 st033236 13.627 µM -0.225388625558211 0.40902080547102 no 2017 0.4108384797542 2959 2916566
SGTC_3075 9116269 49.47 µM -0.225783039359925 0.408867865836675 no 2018 0.410685084554912 3003 17015205 YNL244C SUI1
SGTC_2690 usnic acid 100 µM -0.227065481598 0.408370676396995 no 2019 0.41018641235474 3026 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_503 tyrphostin 8 294 µM -0.227622710893125 0.408154690338329 no 2020 0.409969781320877 2929 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2245 6637752 200 µM -0.227971289918419 0.408019592798661 no 2021 0.409834280094888 2971 681890
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.228665133634335 0.407750714802959 no 2022 0.409564598067997 2760 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3314 9135860 59.4275 µM -0.228749828506245 0.407717896858148 no 2023 0.409531681932893 2904 25252478
SGTC_1906 st060206 94.7 µM -0.229510139269018 0.407423317294937 no 2024 0.409236220469354 2966 5133468
SGTC_2139 5578692 56.4705 µM -0.229961959533386 0.407248286007675 no 2025 0.409060664731325 2907 650991 YMR113W FOL3
SGTC_201 4262-0159 12.803 µM -0.23014001226375 0.407179314995217 no 2026 0.408991486967298 2899 1341029
SGTC_2426 5582046 32.21 µM -0.230169174123033 0.407168019048624 no 2027 0.408980157154356 2971 2251934
SGTC_402 epigallocatechin gallate 10 µM -0.230848191808616 0.406905021058442 no 2028 0.408716370276604 2835 65064 An antioxidant.
SGTC_870 0573-2213 57.6 µM -0.231137892674473 0.406792826519865 no 2029 0.408603838969952 2791 3916321
SGTC_899 1083-0020 478 µM -0.231158978951636 0.406784660584144 no 2030 0.408595648517633 2993 767123
SGTC_3211 9128781 49.47 µM -0.231726377091286 0.406564943486774 no 2031 0.408375271490081 2954 17194361
SGTC_2666 tannic acid 100 µM -0.232577992565631 0.406235222371724 no 2032 0.408044559054364 2891 16134267 A thiamine antagonist.
SGTC_1929 genistein trimethyl ether 50.5 µM -0.232810617733657 0.406145168121669 no 2033 0.407954233846158 3003 136420
SGTC_565 1418-0001 44.5 µM -0.233439331414793 0.405901804270573 no 2034 0.407710137311601 2994 2862145
SGTC_439 amiodarone 34.4 µM -0.234170148837169 0.405618963583738 no 2035 0.407426444279173 2879 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_120 rhodamine 6G 52.259 µM -0.236107458754845 0.404869425410866 no 2036 0.406674643144846 2814 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3004 9076122 71.4286 µM -0.238797920320398 0.403829074826338 no 2037 0.405631141465461 2980 44782551
SGTC_2225 6654152 15.4 µM -0.23939086836548 0.403599884221629 no 2038 0.405401255089396 2882 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_265 mycophenolic acid 32.932 µM -0.240029091846771 0.403353230413551 no 2039 0.405153851858399 3066 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.24004065697821 0.403348761199144 no 2040 0.405149369058821 2919 6708739 YPR165W RHO1
SGTC_2607 solasodine 47.35 µM -0.240728933926586 0.403082807096653 no 2041 0.404882606139471 2855 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_774 k060-0086 136 µM -0.241387103465497 0.402828528593917 no 2042 0.404627553610053 2840 5911235
SGTC_819 1013-0258 27.7 µM -0.24260693906821 0.402357363666349 no 2043 0.404154952598075 2851 5753198
SGTC_2654 protoveratrine a 100 µM -0.24426012566385 0.401719042155786 no 2044 0.403514681682865 2843 5702278 A heart drug and vasodilator.
SGTC_38 0929-0051 58.268 µM -0.244624262240378 0.40157847842689 no 2045 0.403373688086145 2969 1379719
SGTC_2183 6420625 130.508 µM -0.245593915173288 0.401204235874249 no 2046 0.402998299993837 2824 2897619
SGTC_1676 st018489 23.4 µM -0.245939037544869 0.401071055964289 no 2047 0.402864712060719 2873 3696235
SGTC_43 0570-0105 72.5 µM -0.24690584056135 0.400698035811578 no 2048 0.402490548065995 2851 1114046 YDL195W SEC31
SGTC_2628 lathosterol 100 µM -0.247867358544435 0.400327144564709 no 2049 0.402118518014789 2997 6710616
SGTC_61 0978-8327 98.565 µM -0.24791692949157 0.400308025743007 no 2050 0.402099340449371 2857 6150059 YHR072W ERG7
SGTC_2832 7992762 51.95 µM -0.248757308750866 0.399983939594674 no 2051 0.401774257926728 2814 2985177
SGTC_661 1304-0007 33.6 µM -0.248921086296408 0.399920787987961 no 2052 0.401710912034001 2857 3117130
SGTC_789 1309-1135 70.6 µM -0.249171480804619 0.399824242477521 no 2053 0.401614069417976 2828 3092424
SGTC_3113 9123498 49.47 µM -0.24951750911197 0.399690833179118 no 2054 0.401480249405258 2815 8897275
SGTC_3325 9138760 55.175 µM -0.250249768809344 0.399408553133024 no 2055 0.401197099698133 2888 43844959
SGTC_2266 7929956 200 µM -0.25050492260978 0.399310205802228 no 2056 0.401098449172675 2813 2967153
SGTC_138 0850-0259 40.9225 µM -0.252543982507155 0.39852449383352 no 2057 0.40031031119319 2940 6813004
SGTC_1726 st035556 14.5795 µM -0.253469086183321 0.398168158561623 no 2058 0.399952873488698 3062 5919439
SGTC_2402 5553605 200 µM -0.25357994863639 0.398125461793641 no 2059 0.399910044533497 3040 6758546
SGTC_1307 1187-1599 12.2 µM -0.258479012471264 0.396239896589941 no 2060 0.398018622173205 2845 1538471
SGTC_2087 5276107 200 µM -0.262383169337382 0.394738987557876 no 2061 0.396513023593017 2840 144405
SGTC_642 0335-0876 158 µM -0.262412750725971 0.394727621257695 no 2062 0.396501621687161 2860 6812350
SGTC_744 1594-0068 283 µM -0.265336329450863 0.39360471410475 no 2063 0.395375190148473 2913 668392
SGTC_990 3985-0011 41.3 µM -0.267074870176738 0.392937382701657 no 2064 0.394705757864299 2927 5399565 YGL099W LSG1
SGTC_3230 9131665 49.47 µM -0.268158635749759 0.392521542954992 no 2065 0.39428860657683 2865 15943720
SGTC_1493 4348-0038 111 µM -0.268273433598062 0.392477502314734 no 2066 0.394244426926364 2924 800424
SGTC_1301 naphtanilide LB 4.81 µM -0.26946943323255 0.392018755245347 no 2067 0.393784230636046 3017 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2954 9074818 52.69 µM -0.269779717861589 0.391899764511834 no 2068 0.393664863634759 3050 16648742
SGTC_721 1187-1332 279 µM -0.27020370178067 0.39173718770276 no 2069 0.393501772488182 2820 25730
SGTC_1299 1079-1439 3.74 µM -0.27064227501003 0.391569036508225 no 2070 0.393333089024857 2910 323161
SGTC_909 3448-9333 149 µM -0.270992959058697 0.391434597043618 no 2071 0.393198223786828 2859 3344074
SGTC_1747 st037496 66.6 µM -0.271694968488135 0.391165511227031 no 2072 0.392928285190908 2908 723305
SGTC_2469 5655019 90.81 µM -0.272176507224592 0.39098096369652 no 2073 0.39274315235254 3008 2788239
SGTC_893 0958-0369 48.9 µM -0.272607137395333 0.390815947432185 no 2074 0.392577612418926 3022 6819948
SGTC_2580 diallyl disulphide 81.36 µM -0.273077535094368 0.390635714830262 no 2075 0.392396807529097 2892 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1139 k015-0024 46.9 µM -0.273488301862207 0.39047834899876 no 2076 0.392238941735873 3009 2766652
SGTC_76 0433-0009 400.328 µM -0.273553513731839 0.390453367809058 no 2077 0.392213881155086 3002 2841569
SGTC_1074 carmofur 3.8 µM -0.274376127083908 0.39013828213839 no 2078 0.391897793562623 2892 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2880 9042983 58.44 µM -0.274727693151702 0.390003643751786 no 2079 0.391762726726336 3032 6464714
SGTC_1696 st025591 34.7925 µM -0.276309805640774 0.389397909570443 no 2080 0.391155062584409 2891 2787147
SGTC_550 4123-0385 25.7 µM -0.276661569393741 0.389263268285824 no 2081 0.391019991784024 2900 5731123
SGTC_1429 4049-0205 9.46 µM -0.276855633977513 0.389188993709825 no 2082 0.390945480184376 2904 22774478
SGTC_857 0438-0306 1.35 µM -0.277065522913457 0.38910866721763 no 2083 0.390864897289996 2994 4686136
SGTC_1621 st003705 32.4 µM -0.277323038704709 0.389010119949537 no 2084 0.390766035365649 3053 24207032
SGTC_653 0203-0016 55.2 µM -0.277382677366108 0.388987298184073 no 2085 0.39074314071682 2939 295302
SGTC_2618 avocadyne 43.43 µM -0.277731098263443 0.388853976558324 no 2086 0.39060939320623 2865 3015189
SGTC_931 2812-0076 566 µM -0.278677597802587 0.38849186905175 no 2087 0.390246128027868 2871 3450959
SGTC_751 0833-0568 350 µM -0.2792816460922 0.388260825618581 no 2088 0.390014345214838 2976 6954252
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.279437033642241 0.388201397566856 no 2089 0.389954726891544 3021 5024745
SGTC_2495 cafestol 54.53 µM -0.279456423235896 0.388193982190046 no 2090 0.389947287770204 3096 16667697 An anti-infammatory.
SGTC_2429 5902844 64.44 µM -0.280267357969129 0.38788388398038 no 2091 0.389636196084954 3062 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1973 st070275 50.2 µM -0.281247021465394 0.387509359922234 no 2092 0.389260470792305 2894 17118334
SGTC_321 4534-3890 65.3 µM -0.283106839337706 0.386798642206975 no 2093 0.388547469475029 3016 699746
SGTC_2035 5154463 94.595 µM -0.28509538084232 0.386039153342637 no 2094 0.387785534412934 3053 2769623
SGTC_1422 4031-0024 15.5 µM -0.286308162736545 0.385576166491922 no 2095 0.387321053370218 2966 782427
SGTC_743 1275-0778 158 µM -0.286864455053085 0.385363853010429 no 2096 0.387108053937161 3015 2849257 YMR203W TOM40
SGTC_706 4262-0057 46.9 µM -0.287268710199333 0.385209587298157 no 2097 0.386953289519007 2922 883298
SGTC_1470 k295-0292 231 µM -0.288550090995223 0.384720726351903 no 2098 0.38646284654326 3014 5045612
SGTC_2120 5538279 151.968 µM -0.288878660944187 0.384595402767292 no 2099 0.386337116987549 2946 2058197
SGTC_1720 st037298 9.481 µM -0.291694498538247 0.383521878057766 no 2100 0.385260107961209 3008 597396
SGTC_551 k048-0028 34.9 µM -0.294185157876361 0.382573070388733 no 2101 0.384308210702106 3082 6836383
SGTC_2175 5807670 165.306 µM -0.295722793986949 0.381987664771475 no 2102 0.383720894132178 3060 241186
SGTC_2605 digitonin 300 nM -0.298356868506323 0.380985452843996 no 2103 0.382715402340488 3063 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1156 4092-0367 4.88 µM -0.298822188529755 0.380808490745995 no 2104 0.382537860021627 2957 1357585
SGTC_2486 5283202 22.39 µM -0.299705048145597 0.380472806090727 no 2105 0.382201073829896 2981 1377751
SGTC_1609 st001574 46.4 µM -0.300212310537349 0.380279973304352 no 2106 0.382007607738264 2923 3960012
SGTC_542 3381-0244 89.3 µM -0.300973314701925 0.379990737898057 no 2107 0.381717421692124 3112 1112843
SGTC_396 dithiazanine 1.25 µM -0.301469432629408 0.37980221412275 no 2108 0.381528277819747 2950 10578 An antihelmenthic.
SGTC_1434 4073-0095 163 µM -0.302705341393047 0.379332695675519 no 2109 0.381057213410938 2963 24133745
SGTC_2749 bexarotene 57.39 µM -0.303413124250298 0.379063890928279 no 2110 0.380787522549231 3035 82146 An retinoic acid receptor inhibitor.
SGTC_3000 9075062 71.4286 µM -0.303738135473334 0.378940476382012 no 2111 0.380663700915126 2965 17057871
SGTC_1408 3909-7976 48.8 µM -0.30395550988912 0.378857940995883 no 2112 0.380580893194256 2982 24152374
SGTC_226 1,3-diallylurea 8.28947 mM -0.304401358957144 0.378688672837111 no 2113 0.380411066294504 3036 74537 YKL182W FAS1
SGTC_716 1683-5115 658 µM -0.304564765751205 0.378626640701071 no 2114 0.380348829320591 2919 723597
SGTC_1496 4469-0713 57.4 µM -0.305063059515851 0.378437498805854 no 2115 0.380159062608113 3051 746691
SGTC_1058 3448-5425 97.3 µM -0.305255891808344 0.378364311511869 no 2116 0.380085633445102 2937 7279705
SGTC_2416 tofa 880 nM -0.305319767845292 0.378340069053638 no 2117 0.38006131085823 2955 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2768 sulfasalazine 50.2 µM -0.305625747402911 0.378223949258319 no 2118 0.379944807167221 3070 5384001 An antioxidant and salicylic acid derivative.
SGTC_2959 9079155 11 µM -0.306940954289224 0.377724951226228 no 2119 0.379444157837061 3106 16189457
SGTC_278 4092-0821 23.9 µM -0.307437546962091 0.377536593748289 no 2120 0.379255176368936 3020 877900
SGTC_2027 5150920 200 µM -0.308491967214611 0.377136749022984 no 2121 0.378854005818277 3000 786715
SGTC_2172 5754775 163.918 µM -0.309020929336816 0.376936211868051 no 2122 0.378652803087471 2940 2263357
SGTC_826 1683-5028 118 µM -0.312897983176939 0.37546738143054 no 2123 0.377179084946498 3035 722377
SGTC_2545 solidagenone 89.61 µM -0.313862042991761 0.3751024243696 no 2124 0.376812909984718 2873 6708572 An anti ulcer agent
SGTC_252 miconazole 1.30953 nM -0.313945065756434 0.375071000273348 no 2125 0.376781380958488 3057 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2760 etidronate 98.04 µM -0.316030281274866 0.374282019176076 no 2126 0.375989761985443 2984 3305 A chelator and antioxidant.
SGTC_2525 harmine 47.85 µM -0.316760341792971 0.374005911041045 no 2127 0.375712729193277 3000 5280953 A monoamine oxidase inhibitor
SGTC_2214 7179297 48.276 µM -0.316928183505501 0.373942442610594 no 2128 0.375649048102508 2971 769744
SGTC_2776 terbinafine 19.92 µM -0.317447365850395 0.373746138273935 no 2129 0.375452085756223 3005 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2487 5918373 44.05 µM -0.318048704008414 0.373518811521067 no 2130 0.37522399651035 3056 2876279
SGTC_290 2043-6722 48.1 µM -0.31900484242451 0.373157448559962 no 2131 0.374861420379195 3056 773758 YLR208W SEC13
SGTC_1161 k007-0610 110 µM -0.319013425350011 0.373154205233724 no 2132 0.374858166158348 3065 5843850
SGTC_1427 4048-4900 550 nM -0.319149503718053 0.373102784977014 no 2133 0.374806573162134 3083 24132586
SGTC_1475 4092-1048 11.7 µM -0.320752724919263 0.372497142379573 no 2134 0.374198893939738 3041 2881759
SGTC_971 1315-0384 26.7 µM -0.321088676161766 0.372370271282747 no 2135 0.374071595728694 2987 6769120
SGTC_2644 guaiazulene 100 µM -0.321266050021586 0.372303292100211 no 2136 0.374004390992527 3049 3515 A coloring agent.
SGTC_2296 7971656 126.45 µM -0.321749807055542 0.372120637410673 no 2137 0.373821120975413 3042 666570
SGTC_92 0063-0024 660.874 µM -0.322677137464627 0.37177058085349 no 2138 0.373469884187925 2941 3594437
SGTC_3167 9103034 49.47 µM -0.322834782635493 0.371711082148617 no 2139 0.373410184755424 2989 5127859
SGTC_2754 granisetron 64.02 µM -0.322878752340985 0.371694487575073 no 2140 0.373393534191156 3105 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1766 st045414 44.774 µM -0.324498112857072 0.371083492252657 no 2141 0.372780475377432 2981 253960
SGTC_2222 6885208 172.143 µM -0.324662064141423 0.371021650442799 no 2142 0.372718424497912 3014 609514
SGTC_2280 7785178 200 µM -0.325943500360447 0.370538412374821 no 2143 0.372233551387084 2980 2954328
SGTC_351 caspofungin 25 nM -0.326545605283828 0.37031142509338 no 2144 0.372005795264059 3004 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3040 9091894 49.47 µM -0.326691809764384 0.370256314338004 no 2145 0.371950497760188 2968 25236966
SGTC_53 0973-0023 39.979 µM -0.328301600751136 0.369649691224723 no 2146 0.371341816984712 3060 674768
SGTC_2908 7930301 100 µM -0.329848532916642 0.369067060922681 no 2147 0.370757206855872 2984 2223178
SGTC_488 nitrendipine 139 µM -0.33023800177395 0.368920420271233 no 2148 0.370610067359965 2986 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2262 9014885 67.46 µM -0.333719673862468 0.367610370349505 no 2149 0.369295551137088 2968 6457424
SGTC_2136 5328288 199.296 µM -0.335262531872758 0.367030329820465 no 2150 0.368713527502571 3012 262395
SGTC_2848 9016370 25.97 µM -0.336053302848048 0.366733155418527 no 2151 0.36841533575954 3115 7894410
SGTC_247 mechlorethamine 29.705 µM -0.33639149802097 0.366606084901268 no 2152 0.368287829956856 2993 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2904 7225135 42.03 µM -0.33815189579916 0.365944884721483 no 2153 0.367624362153973 3120 4446116
SGTC_1252 0493-0875 34.8 µM -0.338216156741072 0.365920756019257 no 2154 0.367600150616848 2975 3960963
SGTC_2935 9038016 29.96 µM -0.339334382834876 0.365500969402004 no 2155 0.367178921905796 3172 6463195
SGTC_1397 3532-0190 20.1 µM -0.341591768726741 0.364654028742132 no 2156 0.366329066296302 2932 5322280
SGTC_433 pimozide 108 µM -0.343798470277288 0.363826742146693 no 2157 0.365498925364437 2964 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3334 9142812 21.919 µM -0.344112443626444 0.363709085828601 no 2158 0.36538086254015 3119 45283678
SGTC_2383 9036125 200 µM -0.344465137356136 0.363576935014929 no 2159 0.365248254974056 3007 79580
SGTC_1911 st060208 74.3 µM -0.345741771273542 0.363098728857 no 2160 0.36476839451521 3119 688783
SGTC_223 busulfan 5 mM -0.345906767437968 0.363036939549153 no 2161 0.364706391285183 3093 2478 A DNA alkylator.
SGTC_1554 st069299 38.7 µM -0.345956819237985 0.363018196387322 no 2162 0.364687583224581 3087 24207999
SGTC_2405 ticlatone 3.52 µM -0.346900256184815 0.362664963994812 no 2163 0.364333127089156 2841 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2819 7996655 46.38 µM -0.347405130980091 0.362475981711786 no 2164 0.36414348957504 3060 6456960
SGTC_316 k060-0003 58.6 µM -0.347580135119267 0.362410482829068 no 2165 0.36407776351317 3141 6152314
SGTC_2086 5274770 176.623 µM -0.348893540273384 0.36191904270641 no 2166 0.363584617474788 3086 689278
SGTC_2241 6772625 37.8075 µM -0.349297594890434 0.36176790231046 no 2167 0.3634329519407 3016 2285411
SGTC_555 4296-0685 37 µM -0.350764998451526 0.361219187814861 no 2168 0.362882328994453 3074 2908540 YHR072W ERG7
SGTC_2373 9071805 200 µM -0.35078330812303 0.361212342976586 no 2169 0.362875460330367 3186 10149009
SGTC_2197 6588183 93.1375 µM -0.350920044863374 0.361161227087002 no 2170 0.362824166499419 3022 884136
SGTC_2612 dictamnine 15.46 µM -0.351433310024044 0.360969376819802 no 2171 0.362631648140187 3097 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2792 7535235 81.82 µM -0.351864798975058 0.360808120241859 no 2172 0.362469829721314 3090 1281891
SGTC_35 0133-0054 64.071 µM -0.352941926218242 0.360405682962726 no 2173 0.362065989149604 3062 99677
SGTC_3225 9130819 49.47 µM -0.353292263938331 0.360274822756234 no 2174 0.361934672283904 3151 4547121
SGTC_2735 sertaconazole 140 nM -0.353634462625548 0.360147018490791 no 2175 0.361806421856955 3066 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1426 4048-4480 71.7 µM -0.354290149079998 0.359902176580744 no 2176 0.361560724750419 3144 14224343
SGTC_1071 trifluoperazine 6.31 µM -0.355254776820068 0.359542076445029 no 2177 0.361199365741754 3174 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2703 st077852 53.4 µM -0.359897439839676 0.357810697450604 no 2178 0.359461915821526 3155 6281836
SGTC_2747 doxorubicin 7.63 µM -0.361218194409545 0.35731868327346 no 2179 0.358968170949737 3062 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1075 aripiprazole 15.2 µM -0.363140865590028 0.356602864063081 no 2180 0.35824982946248 3022 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2917 7979103 53.79 µM -0.36511165936576 0.355869652435113 no 2181 0.357514028955767 3195 2980565
SGTC_178 4092-0806 87.505 µM -0.365273457757373 0.355809480796752 no 2182 0.357453644620138 3129 2169044
SGTC_1400 3771-8998 51.5 µM -0.365566878659377 0.3557003688745 no 2183 0.357344146912105 3037 670767
SGTC_3215 9129942 49.47 µM -0.365992473341664 0.355542127629778 no 2184 0.357185345964212 3185 17682944
SGTC_1572 epiandrosterone 68.9 µM -0.366994597725549 0.355169624046035 no 2185 0.356811523838593 2992 441302 A steroid.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.367141232141874 0.355115129587736 no 2186 0.356756836371395 3087 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1188 1403-0014 4.57 µM -0.367701063120927 0.354907104150933 no 2187 0.356548073875881 3068 9614867
SGTC_346 4513-0042 7.16 µM -0.367869820577349 0.354844404698611 no 2188 0.356485152187278 3010 2827372
SGTC_2779 methotrexate 400 µM -0.369404681140367 0.354274329579257 no 2189 0.355913054654848 3147 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2212 7123476 200 µM -0.37113065209919 0.353633662482597 no 2190 0.355270110844954 3080 1085715
SGTC_2218 6965428 192.983 µM -0.372315672551479 0.353194031827943 no 2191 0.354828915527375 3141 675684
SGTC_2839 9003951 25.97 µM -0.372879412342989 0.352984958752107 no 2192 0.35461909767734 3173 2990634
SGTC_8 0354-0001 70 µM -0.375362937914403 0.35206442762366 no 2193 0.353695282201758 3095 4993152
SGTC_1279 0874-0590 65.2 µM -0.375404121066601 0.352049170169974 no 2194 0.353679970240338 3109 3523074
SGTC_3328 9140624 29.0385 µM -0.375892769146772 0.351868154970462 no 2195 0.353498308181945 3204 4904392
SGTC_1097 itavastatin 7.23 µM -0.377297812479027 0.351347856718521 no 2196 0.352976148830414 3098 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1685 st024049 53.0905 µM -0.380123444272832 0.350302347604735 no 2197 0.351926891829797 3125 1941139
SGTC_2145 5634607 200 µM -0.380563556537892 0.350139603930447 no 2198 0.351763563786657 3064 308662
SGTC_1813 st051246 8.6015 µM -0.380973315883413 0.349988108822237 no 2199 0.351611524464616 3165 5291959
SGTC_1309 pyrazolanthrone 13.4 µM -0.38120723277112 0.349901636411234 no 2200 0.351524741318141 3189 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2466 5983409 37.09 µM -0.38148040804264 0.349800661147593 no 2201 0.351423403109937 3102 2879657
SGTC_2991 9074669 71.4286 µM -0.381974946295889 0.349617889305714 no 2202 0.351239974058175 3252 17333109
SGTC_2858 9025781 8.96 µM -0.38228713862892 0.349502526956991 no 2203 0.351124196720184 3165 4894980 YPL153C RAD53
SGTC_1758 st042942 75.2445 µM -0.382771302721159 0.349323644526575 no 2204 0.35094467054161 3145 669317
SGTC_1547 harmine 94.2 µM -0.382992371411563 0.349241978168844 no 2205 0.350862710184211 3107 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1331 1472-0049 76.2 µM -0.384414328754934 0.348716851059877 no 2206 0.35033569103887 3035 24051409
SGTC_2276 7947513 42.08 µM -0.38499431531086 0.348502745855459 no 2207 0.35012081363069 3147 2105100
SGTC_1637 st007924 17.4 µM -0.385152473989574 0.348444369086203 no 2208 0.350062226238038 3053 683336
SGTC_1359 1582-0056 520 nM -0.386483718744389 0.347953145652006 no 2209 0.34956922913807 3172 3661189
SGTC_2033 5192550 145 µM -0.386547895233015 0.347929471249116 no 2210 0.349545469193657 3103 182073
SGTC_2521 angolensin 13.4 µM -0.387013532980847 0.347757717446995 no 2211 0.349373094636789 3226 821428 A flavenoid.
SGTC_2255 7941087 197.44 µM -0.388658720814822 0.347151128566292 no 2212 0.348764311089241 3234 935561
SGTC_1105 epirubicin 18.1 µM -0.388995041125818 0.347027173739078 no 2213 0.348639907341859 3066 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1992 st073643 23.3 µM -0.39006262791975 0.34663381049086 no 2214 0.348245118471083 3071 3161292
SGTC_2343 7990716 14.84 µM -0.390169407502719 0.346594475550449 no 2215 0.348205640889722 3059 6456862
SGTC_1283 0922-0125 16.4 µM -0.390317320611434 0.346539990775417 no 2216 0.348150958510508 3176 3360884
SGTC_2565 isoliquiritigenin 100 µM -0.390936222267418 0.346312048686672 no 2217 0.34792218940994 3199 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1800 st050079 29.0735 µM -0.392602109800776 0.345698777381508 no 2218 0.347306690519675 3192 3645560
SGTC_2456 5770359 74.46 µM -0.393345369053513 0.345425288184729 no 2219 0.347032206737406 3242 3118787
SGTC_2900 5328528 85.29 µM -0.39352493249857 0.345359228229695 no 2220 0.346965906435119 3092 795359
SGTC_422 cantharidin 155 µM -0.395521443931131 0.344625045404122 no 2221 0.346229049536203 3034 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3227 9130768 49.47 µM -0.395837244691574 0.344508968594794 no 2222 0.346112549463002 3097 17720899
SGTC_1066 ketoconazole 628 nM -0.400286093204152 0.342875295004041 no 2223 0.344472904834982 3236 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_872 0588-0139 234 µM -0.401943104396969 0.342267567586284 no 2224 0.343862949530962 3107 2047100
SGTC_378 3970-0959 8.33 µM -0.402157987998834 0.342188786489946 no 2225 0.34378387936467 3215 6615653
SGTC_1052 3253-3998 198 µM -0.402867626360883 0.341928666129689 no 2226 0.343522804119802 3055 5450317
SGTC_589 1227-0070 34.1 µM -0.40290925159151 0.341913410587517 no 2227 0.343507492555058 3232 2841384
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.403955740667653 0.341529959850743 no 2228 0.343122632935802 3137 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1056 3448-1962 115 µM -0.40410278839537 0.341476092247464 no 2229 0.343068567296275 3187 715507
SGTC_2924 9010168 62.78 µM -0.404264589972169 0.341416823637137 no 2230 0.343009080761031 3198 2993929
SGTC_2813 7971799 71.43 µM -0.405529421909823 0.340953645159608 no 2231 0.342544198042724 3199 2234054
SGTC_1820 st053765 18.6 µM -0.405943467650165 0.340802074607859 no 2232 0.3423920693415 3178 3690829
SGTC_875 0709-0210 25.7 µM -0.406179249335735 0.340715773016534 no 2233 0.342305449849838 3249 6251364
SGTC_352 k048-0007 5.11 µM -0.406229540959248 0.340697366189014 no 2234 0.342286975209594 3213 6811911
SGTC_2261 9010538 184.68 µM -0.407002706808463 0.340414433820012 no 2235 0.342003000072709 3216 6457250
SGTC_130 0136-0219 337.655 µM -0.407025455655131 0.340406110464547 no 2236 0.341994646029119 3088 234244
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.410923926653193 0.338980887786959 no 2237 0.340564158644022 3104 6312947
SGTC_1959 st077091 55.8 µM -0.412730491524485 0.338321213795395 no 2238 0.339902041173129 3063 821356 YKL052C ASK1
SGTC_2899 9053889 58.44 µM -0.412778212168936 0.338303795136288 no 2239 0.339884557936914 3225 6470052
SGTC_2103 5378138 10 µM -0.4135640581054 0.338017000888912 no 2240 0.339596700019633 3218 244142
SGTC_2866 9034245 58.44 µM -0.414470400296856 0.337686348284251 no 2241 0.339264820093609 3165 6462273
SGTC_3353 9151644 39.2805 µM -0.414948492966731 0.33751198051208 no 2242 0.339089804674352 3247 4909158
SGTC_215 1287-0124 461.5 µM -0.415140319601284 0.337442028182839 no 2243 0.339019592441358 3158 5560863
SGTC_3136 9095672 49.47 µM -0.41754114782519 0.336567007601206 no 2244 0.338141316775059 3161 17217380
SGTC_325 2810-4341 181 µM -0.418112838878983 0.336358775742065 no 2245 0.337932309201782 3253 774970
SGTC_3116 9124943 49.47 µM -0.418299016762653 0.336290973429793 no 2246 0.337864254219116 3156 41905195 YPL160W CDC60
SGTC_3251 9135047 49.47 µM -0.418468958909251 0.336229088500705 no 2247 0.337802138632468 3223 17682963
SGTC_2284 7945075 39.21 µM -0.419779681946865 0.335751934091398 no 2248 0.3373232045319 3263 1245402
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.421690198776745 0.33505690550289 no 2249 0.336625579696889 3241 7104
SGTC_1177 0983-0204 23.6 µM -0.423881012835889 0.334260602085658 no 2250 0.335826296007293 3276 766818
SGTC_2781 5567276 71.43 µM -0.42445484983935 0.334052150426189 no 2251 0.33561706318202 3283 2853274
SGTC_410 α-linolenic acid 100 µM -0.425098359494041 0.333818450407738 no 2252 0.335382486883675 3271 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1068 loratadine 26.9 µM -0.426006224120759 0.333488855593861 no 2253 0.335051655331471 3188 3957 A H1 histamine antagonist.
SGTC_1948 st076329 66.6 µM -0.4260360958947 0.333478013007456 no 2254 0.33504077204271 3163 24208413
SGTC_1646 st011709 75.6 µM -0.426297396337932 0.333383174466746 no 2255 0.334945577436237 3251 5757843
SGTC_1561 5-methoxyflavone 52.9 µM -0.428740681054412 0.332496904589665 no 2256 0.334055975938097 3213 94525
SGTC_2830 7992007 71.43 µM -0.429062510110875 0.332380234896746 no 2257 0.333938867105221 3051 1952075
SGTC_2160 5660466 132.927 µM -0.429617673987279 0.332179014676544 no 2258 0.333736889193812 3252 2859134
SGTC_2664 lyso-paf C-16 73.48 µM -0.429630382469545 0.332174409028728 no 2259 0.333732266198969 3146 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2446 5162541 200 µM -0.431200964381662 0.33160541388362 no 2260 0.333161126388627 3121 1549321
SGTC_394 menadione 8.33 µM -0.431733019427001 0.331412747373843 no 2261 0.332967732974888 3265 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1044 1222-0021 1.78 µM -0.431809397478893 0.331385093195205 no 2262 0.332939974431729 3218 4306703
SGTC_324 1315-0088 19.6 µM -0.432619686636797 0.331091768676834 no 2263 0.332645542481254 3231 6787421
SGTC_118 0083-0097 135.343 µM -0.433377890887786 0.330817392729478 no 2264 0.332370129896493 3235 5207356
SGTC_2203 7227154 166.4 µM -0.433427404504457 0.330799478097308 no 2265 0.332352147554874 3214 896304
SGTC_720 r052-1644 49.9 µM -0.43392919861031 0.330617944721494 no 2266 0.332169927889571 3238 1422863 YOR257W CDC31
SGTC_986 1493-0483 84 µM -0.435886819248786 0.329910120146685 no 2267 0.331459424367981 3272 40079
SGTC_803 4488-1585 147 µM -0.436979151594772 0.329515425606434 no 2268 0.331063233926965 3270 747204
SGTC_1393 3470-5649 58.2 µM -0.437628262041345 0.329280971180582 no 2269 0.330827890210586 3215 4108395
SGTC_2358 9037157 4 µM -0.437771033118422 0.329229412207549 no 2270 0.33077613560302 3249 2388925
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.438299497817323 0.329038595815975 no 2271 0.330584594960481 3191 65057 A dermal irritant. YDR527W RBA50
SGTC_3197 9113331 49.47 µM -0.438514755891074 0.328960883862705 no 2272 0.330506587949102 3357 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1842 st055362 61.2 µM -0.438597472482993 0.328931023683147 no 2273 0.330476614380593 3156 676032
SGTC_2229 7354935 190 µM -0.440067150553392 0.328400661140565 no 2274 0.329944236462098 3247 318112
SGTC_187 1488-2104 32.728 µM -0.440490079114347 0.328248102953556 no 2275 0.329791098058741 3250 2852859
SGTC_604 1000-0114 314 µM -0.441184303724112 0.327997745340416 no 2276 0.329539787794248 3308 1572745
SGTC_1409 3909-8004 61.9 µM -0.441535334519679 0.327871182816293 no 2277 0.329412743452395 3225 2119279
SGTC_793 0488-0545 106 µM -0.441899891213806 0.327739764515879 no 2278 0.329280824687408 3156 292548
SGTC_2379 9035213 200 µM -0.442093491991192 0.327669982437626 no 2279 0.329210776799712 3310 646551
SGTC_3240 9133527 49.47 µM -0.442417428269339 0.327553235279032 no 2280 0.329093584831833 3198 17617455
SGTC_1140 3229-1848 2.98 µM -0.442560397893467 0.327501714157151 no 2281 0.329041867372148 3280 2849525
SGTC_1237 0330-0133 46.1 µM -0.443651987626126 0.327108452738503 no 2282 0.32864710647384 3153 X1237 YHR072W ERG7
SGTC_2040 5100729 123 µM -0.44427256976047 0.326884964326143 no 2283 0.328422765260801 3172 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_466 geldanamycin 89.2 µM -0.445056272187878 0.326602820595076 no 2284 0.32813954423179 3199 5288382 HSP90 inhibitor.
SGTC_3160 9100216 49.47 µM -0.445782359894221 0.326341507437502 no 2285 0.327877232639467 3255 17191039
SGTC_2689 tacrolimus 100 µM -0.446157088017978 0.326206679112991 no 2286 0.327741888904887 3245 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1101 ebselen 5.29 µM -0.446755468829931 0.32599142696263 no 2287 0.3275258135502 3329 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2921 7974240 10.71 µM -0.447167363665001 0.325843292043076 no 2288 0.327377111852639 3286 2979074 YDR527W RBA50
SGTC_2132 5317594 122.667 µM -0.449260518220788 0.325090929751722 no 2289 0.326621867746526 3141 794577
SGTC_2317 5986382 200 µM -0.451597969729558 0.324251599700912 no 2290 0.325779316447476 3237 877883
SGTC_1805 st050013 60.3 µM -0.453328931663503 0.323630622143374 no 2291 0.325155951371102 3219 4037144
SGTC_2353 9059630 146.67 µM -0.453928868879011 0.323415510848759 no 2292 0.32494001217377 3284 4779114
SGTC_621 3584-0052 32.1 µM -0.45547339875753 0.322861981515948 no 2293 0.32438435045774 3328 2273927
SGTC_2351 9026858 72.31 µM -0.455587090177488 0.322821252214389 no 2294 0.324343464139065 3139 1409300
SGTC_935 2996-0153 430 µM -0.455789428591199 0.322748770890747 no 2295 0.324270703351219 3323 23738523
SGTC_23 0213-0011 39.996 µM -0.458120685554199 0.321914158273056 no 2296 0.323432869178986 3363 627608
SGTC_984 1492-0255 2.91 µM -0.45823635989723 0.321872769075031 no 2297 0.323391320050653 3288 1585198
SGTC_2437 5741531 144.16 µM -0.460337810008594 0.321121238720901 no 2298 0.322636882939513 3369 2262990
SGTC_1776 st049249 45.9 µM -0.460527528952595 0.321053426534196 no 2299 0.322568808209063 3267 1822314
SGTC_888 0916-0002 6.97 µM -0.460618302751685 0.32102098291383 no 2300 0.322536238963717 3350 2802138 YIL048W NEO1
SGTC_2002 4023503 131 µM -0.461190527652165 0.320816494486941 no 2301 0.322330958509643 3408 4736863 YCR052W RSC6
SGTC_1509 1326-1131 80 µM -0.461328317247781 0.32076726256297 no 2302 0.322281535841364 3295 768313
SGTC_1236 0330-0013 258 µM -0.461872892450334 0.320572717876285 no 2303 0.322086237187783 3213 4617066
SGTC_2584 androsterone 48.74 µM -0.461964639094087 0.320539947046555 no 2304 0.322053339318266 3308 2754130 A steroid.
SGTC_1120 ficusin 1.78878 µM -0.462232051773536 0.320444438342151 no 2305 0.321957460306252 3322 6199 A DNA cross-linker.
SGTC_305 1682-2595 20.8 µM -0.464281515454609 0.319712850170785 no 2306 0.321223032776629 3285 226033
SGTC_2531 methyl deoxycholate 70.07 µM -0.466297947528763 0.318993737064738 no 2307 0.320501123846295 3167 16667744 Haematoxylin.
SGTC_3174 9107204 49.47 µM -0.466320353542058 0.318985750306091 no 2308 0.320493106008946 3329 3938802
SGTC_3036 9090181 49.47 µM -0.466419133834361 0.318950540476842 no 2309 0.320457759161337 3263 25236586
SGTC_405 ebelactone b 50 µM -0.466926594978779 0.318769683797914 no 2310 0.32027619849957 3254 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1808 st050063 61.5 µM -0.467230294368927 0.31866146745359 no 2311 0.320167560778029 3348 4011993
SGTC_111 0083-0039 52.457 µM -0.46744846527999 0.318583736774174 no 2312 0.320089527360203 3197 759313
SGTC_1748 st037455 53.6035 µM -0.468638770025821 0.318159791587247 no 2313 0.319663930036833 3363 580690
SGTC_1965 Pectolinarigenin 58.4 µM -0.468734424196671 0.318125733224793 no 2314 0.319629738874354 3230 5320438 An anti-inflammatory.
SGTC_902 1120-0002 2.07 µM -0.469461211605203 0.31786700553664 no 2315 0.319370002004356 3280 3280475
SGTC_2850 9015429 58.44 µM -0.469831057963623 0.317735378741858 no 2316 0.319237861552214 3255 6457570
SGTC_1420 4'-methoxyflavone 42 µM -0.470264048796772 0.317581308354718 no 2317 0.319083189719107 3314 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2190 6049624 200 µM -0.474055105096273 0.316233694816776 no 2318 0.317730306063344 3282 2265554
SGTC_2624 nerol 100 µM -0.474476454092688 0.316084067314183 no 2319 0.317580092369396 3255 637566 A natural product oil.
SGTC_1683 st010134 710 nM -0.476041156062547 0.315528681356372 no 2320 0.317022528772395 3212 3818134
SGTC_2575 plumbagin 510 nM -0.476244740387634 0.315456450341655 no 2321 0.316950014333091 3182 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_25 0118-0223 35.662 µM -0.476587558240321 0.315334835687572 no 2322 0.316827922370351 3375 5333628
SGTC_1628 st004252 77.7 µM -0.47801163664154 0.314829858063828 no 2323 0.316320961360909 3344 692968
SGTC_1216 1165-0504 9.65 µM -0.478053577005122 0.314814991268935 no 2324 0.316306036138295 3357 6304004
SGTC_1263 0774-1208 64.8 µM -0.47885184305137 0.314532083446962 no 2325 0.316022016074841 3396 906585
SGTC_298 1391-0729 10 µM -0.48029244634001 0.314021805016477 no 2326 0.315509729628296 3250 3237558
SGTC_3210 9128157 49.47 µM -0.480952239966938 0.313788217038094 no 2327 0.315275221644316 3252 17590849
SGTC_270 tamoxifen 5.46 µM -0.482237378668991 0.313333451245464 no 2328 0.314818663270408 3434 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_42 0133-0086 60.653 µM -0.482585143574416 0.313210438107608 no 2329 0.314695164914579 3216 162923 Model of phenazepam hydroxylation.
SGTC_599 1935-0052 86.5 µM -0.483171955489749 0.313002915194668 no 2330 0.314486823122824 3222 9557311
SGTC_2127 5253358 187.912 µM -0.484297862973188 0.312604909884853 no 2331 0.314087246183165 3196 20612
SGTC_1012 4112-3522 18 µM -0.484946549160294 0.312375700185166 no 2332 0.313857130724106 3371 3112398
SGTC_1810 st050138 53 µM -0.485071073597124 0.312331708460615 no 2333 0.313812965103631 3337 3444541
SGTC_1692 fluoroquinolonic acid 71 µM -0.485893739744861 0.312041145972587 no 2334 0.313521253595738 3355 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2150 5556613 200 µM -0.486557612627109 0.311806753871996 no 2335 0.313285934031683 3253 743190
SGTC_1885 st057546 99.9 µM -0.487118879376238 0.311608648131303 no 2336 0.313087044013589 3418 702008
SGTC_1828 st055811 49 µM -0.487340158173817 0.311530560141736 no 2337 0.313008646783422 3341 5877589
SGTC_586 0957-0265 8.15 µM -0.487947055426196 0.311316433175133 no 2338 0.312793671552388 3301 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.488341980673562 0.311177128961518 no 2339 0.312653815258051 3256 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1 0258-0098 57.368 µM -0.48914307119789 0.31089463885157 no 2340 0.312370205054426 3262 6790032 YDR047W HEM12
SGTC_2930 9013230 14.89 µM -0.489559695266412 0.310747767921608 no 2341 0.312222751480379 3352 2995857
SGTC_1023 4482-3888 16 µM -0.489876981993134 0.310635936237799 no 2342 0.312110476021757 3392 3303168
SGTC_1518 st038567 90.8 µM -0.490307974595056 0.310484055518231 no 2343 0.311957992419007 3344 77966
SGTC_1987 st072290 61.9 µM -0.490641011311531 0.310366716332348 no 2344 0.311840187315619 3277 54697379
SGTC_695 3505-6186 243 µM -0.490794677344186 0.310312581518914 no 2345 0.311785837506956 3347 1819379
SGTC_1079 idarubicin 2.36 µM -0.491627323282592 0.310019321214301 no 2346 0.311491412057187 3354 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_520 3584-0023 682 µM -0.492136235865903 0.309840140206692 no 2347 0.311311518761054 3283 1340790
SGTC_868 0527-0199 213 µM -0.492660781545638 0.309655502271783 no 2348 0.311126146536473 3250 2849450
SGTC_1659 st012954 42.1 µM -0.492938911937355 0.309557620989706 no 2349 0.31102787586173 3353 24207262
SGTC_2259 7964009 200 µM -0.496141159868802 0.308431641461333 no 2350 0.309897410624642 3387 313134
SGTC_3068 9116768 49.47 µM -0.497211316673696 0.308055751861472 no 2351 0.309520020958305 3358 41904888
SGTC_652 0437-0092 114 µM -0.497398340948087 0.307990080754576 no 2352 0.309454087644303 3334 3091274
SGTC_386 1509-0011 3.07 µM -0.497689684247476 0.30788779164727 no 2353 0.309351390045422 3325 3107280
SGTC_3153 9100258 49.47 µM -0.499828277052755 0.307137400233231 no 2354 0.308597999016792 3259 25236848
SGTC_1292 0kpi-0043 232 µM -0.500407922543642 0.30693415255587 no 2355 0.30839393799134 3319 3333905
SGTC_471 1-acyl-paf 4 µM -0.500590434638408 0.306870168545952 no 2356 0.308329697854781 3254 16759367
SGTC_1002 4049-0206 172 µM -0.502054402650316 0.306357152281639 no 2357 0.307814626645933 3287 4662749
SGTC_1336 1486-0901 104 µM -0.502199984588694 0.306306156928674 no 2358 0.307763426894085 3346 5006114
SGTC_1946 st076057 65.1 µM -0.503785567570462 0.305750992118617 no 2359 0.307206035345527 3303 953009
SGTC_1710 st031758 61.5 µM -0.504595348320985 0.305467633234424 no 2360 0.306921538840141 3430 5394341
SGTC_585 0kpi-0023 191 µM -0.504903018287724 0.305360003735972 no 2361 0.306813477042189 3351 64601
SGTC_776 4476-4378 112 µM -0.505374959334579 0.305194941416882 no 2362 0.30664775153676 3370 2892008
SGTC_2207 7258803 200 µM -0.505515623525616 0.305145751497808 no 2363 0.306598363934771 3357 3666799
SGTC_757 1066-0008 322 µM -0.50735844577711 0.304501646483816 no 2364 0.305951668380224 3387 6842497
SGTC_2274 7947094 46.08 µM -0.508258579662715 0.304187250899158 no 2365 0.305636006950906 3387 2971028
SGTC_199 4063-0024 41.6 µM -0.508474196961534 0.304111962325047 no 2366 0.30556041511063 3388 306215
SGTC_1824 st053723 68.6 µM -0.509115822353841 0.303887970715802 no 2367 0.305335520947497 3332 675225
SGTC_625 k213-0058 121 µM -0.511696253361592 0.302987885513476 no 2368 0.304431804342568 3368 3655420
SGTC_947 3447-0010 211 µM -0.511722508552241 0.302978733522662 no 2369 0.304422615390227 3381 748350
SGTC_2942 9052777 62.25 µM -0.511907763456184 0.302914161191867 no 2370 0.304357782253956 3370 6469503
SGTC_2970 9090938 41.86 µM -0.512444222947516 0.302727207972622 no 2371 0.304170073723898 3439 17217104
SGTC_1801 st050089 28.441 µM -0.515440771799473 0.301683879061935 no 2372 0.303122523843743 3389 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_559 1550-0661 158 µM -0.516481001073092 0.301322073770639 no 2373 0.302759252507142 3385 5830875
SGTC_2465 5809242 33.21 µM -0.517014566038158 0.301136568767313 no 2374 0.302572995373685 3363 2731748
SGTC_3129 9127257 49.47 µM -0.517517083449325 0.300961905163844 no 2375 0.302397623312531 3251 837894
SGTC_3008 9078912 71.4286 µM -0.517793320717476 0.30086591084273 no 2376 0.302301239509035 3330 16648731
SGTC_141 0443-0274 32.331 µM -0.518414083860888 0.300650241850339 no 2377 0.302084695169182 3496 1627241
SGTC_273 hydroxyurea 18.1 mM -0.519402504395307 0.300306983377966 no 2378 0.301740042629732 3350 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_20 0481-0013 4.944 µM -0.521340850209259 0.299634349869868 no 2379 0.30106467429274 3384 182045
SGTC_1650 st011916 45.8 µM -0.522701002501526 0.299162765653764 no 2380 0.300591170255481 3431 242528
SGTC_2258 7960471 200 µM -0.524837191942832 0.298422799078723 no 2381 0.299848187242944 3355 2974708
SGTC_966 1300-0360 30.2 µM -0.525424612625309 0.29821946525753 no 2382 0.299644023679849 3307 70588
SGTC_1206 3978-0017 132 µM -0.525950821944351 0.298037373150552 no 2383 0.299461188196772 3502 3873677
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.526899056040561 0.297709369462109 no 2384 0.29913184470956 3411 364106
SGTC_1185 1319-0113 81.3 µM -0.52745250765447 0.297518001145771 no 2385 0.298939694264156 3404 4672763
SGTC_3268 9137683 49.47 µM -0.527706097826682 0.297430335419057 no 2386 0.298851670134879 3309 1953228
SGTC_2623 humulene 100 µM -0.52866470994501 0.29709905134536 no 2387 0.298519031055299 3379 6187145 An anti-inflammatory.
SGTC_640 3381-0960 37.1 µM -0.531304181341545 0.296187756870461 no 2388 0.297604004168575 3409 1745025
SGTC_1971 st069429 63.5 µM -0.532443668638497 0.295794738237155 no 2389 0.297209373546791 3408 1246522 YGL099W LSG1
SGTC_366 0181-0206 4.31 µM -0.533741367023421 0.295347443298538 no 2390 0.29676024232366 3501 274874
SGTC_303 1348-1668 34.2 µM -0.533795402544865 0.295328824908953 no 2391 0.29674154746109 3381 5380509
SGTC_3231 9132313 49.47 µM -0.535708604642173 0.294669963553274 no 2392 0.296079977914137 3370 4905967
SGTC_1655 st012546 55.1 µM -0.537033627583878 0.294214054864378 no 2393 0.295622192987946 3394 720985 YLR208W SEC13
SGTC_2937 9044753 11.33 µM -0.537383987244764 0.294093558985699 no 2394 0.295501200913722 3384 6465530 YGL099W LSG1
SGTC_925 2064-1272 59.6 µM -0.537638865481056 0.294005915462803 no 2395 0.295413196398323 3334 6815817
SGTC_880 0833-0487 87.2 µM -0.537797764704356 0.293951281806174 no 2396 0.295358337678033 3404 76075
SGTC_2952 9073731 13.78 µM -0.53820965727967 0.293809684362518 no 2397 0.295216156799276 3355 16457353
SGTC_956 1185-0240 191 µM -0.541269900489209 0.292758645702049 no 2398 0.294160781889148 3346 1416193
SGTC_3152 9099253 49.47 µM -0.541288731304438 0.29275218367804 no 2399 0.294154293174539 3420 25236131
SGTC_1213 1315-0166 115 µM -0.542319174957648 0.292398675389623 no 2400 0.293799324198761 3378 768401
SGTC_2277 7947813 106.88 µM -0.542477705014713 0.292344307029005 no 2401 0.293744731091069 3503 1246798
SGTC_476 mead acid 10 µM -0.542574848867695 0.292310993575139 no 2402 0.293711279913618 3366 5312531 An omega 9 fatty acid.
SGTC_1863 st057641 20.1 µM -0.54381202528407 0.291886884287897 no 2403 0.293285416425142 3443 3921635
SGTC_375 3970-0961 9.27 µM -0.544062249598319 0.291801141196819 no 2404 0.293199318489679 3365 2898222
SGTC_944 3370-0224 231 µM -0.544089573348857 0.291791779017141 no 2405 0.293189917561046 3382 4580514
SGTC_1889 st059080 5.18 µM -0.54445090479088 0.291667985976017 no 2406 0.293065612082161 3475 176925 Isolated from Daphnopsis sellowiana.
SGTC_537 1334-0398 209 µM -0.544833054401742 0.291537087222263 no 2407 0.292934171329111 3459 5846986
SGTC_690 glyoxal 20.3 µM -0.545229719178275 0.291401245532541 no 2408 0.292797767012955 3387 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_426 0988-0037 14.6 µM -0.545936517301934 0.291159268896427 no 2409 0.292554787758164 3486 5383008
SGTC_12 0849-0099 9.267 µM -0.546723552638589 0.290889933023641 no 2410 0.292284335295793 3393 6071388
SGTC_1702 st027038 51 µM -0.547410014269921 0.290655110176196 no 2411 0.29204853841646 3420 5521182
SGTC_557 1315-0110 16.2 µM -0.54744847625323 0.290641955833746 no 2412 0.292035329496124 3413 6833801
SGTC_1437 4092-1038 11.6 µM -0.54756642319246 0.290601618661699 no 2413 0.291994824954024 3382 3977136
SGTC_2393 9031399 185.94 µM -0.548691091370271 0.290217120264508 no 2414 0.291608730445311 3484 1526623 YDL150W RPC53
SGTC_3047 9092122 49.47 µM -0.549077018329994 0.290085235584235 no 2415 0.291476297990866 3386 17173831
SGTC_3117 9124945 49.47 µM -0.54913173735049 0.290066538463558 no 2416 0.291457523200525 3290 17592065
SGTC_1830 st055982 50.3 µM -0.551621261904353 0.28921648277733 no 2417 0.290603933042369 3440 455313 An antimicrobial agent.
SGTC_1186 1319-0216 26 µM -0.551965316329337 0.28909909651943 no 2418 0.29048605820003 3497 4565136
SGTC_314 1671-0008 2.74 µM -0.551973094370503 0.289096443026364 no 2419 0.290483393661206 3379 3913060
SGTC_1691 st019933 84.6 µM -0.553548363306529 0.288559273346068 no 2420 0.28994398661534 3434 6176082
SGTC_2297 7971671 152.32 µM -0.553561328019879 0.288554854306111 no 2421 0.289939549159104 3490 909016
SGTC_1910 st062352 60.4 µM -0.555532541026354 0.287883334983701 no 2422 0.289265229294462 3375 2245730
SGTC_527 4476-4215 268 µM -0.558404366232929 0.286906333303314 no 2423 0.288284145996062 3343 4418754
SGTC_2006 4011487 200 µM -0.560211376256407 0.286292390592156 no 2424 0.287667634133943 3504 45595294
SGTC_1466 k213-0079 57.5 µM -0.56059179973734 0.286163218913362 no 2425 0.287537921493136 3430 3657981
SGTC_963 1269-2853 151 µM -0.56077709733014 0.286100311685979 no 2426 0.287474750761758 3387 3668223
SGTC_485 niflumic acid 177 µM -0.561727101710397 0.285777895125793 no 2427 0.287150983128624 3467 4488 A COX2 inhibitor.
SGTC_415 dibenzyl ketone 100 µM -0.563436160400785 0.285198302937922 no 2428 0.286568959897891 3420 7593
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.563725918958973 0.28510009283331 no 2429 0.286470337569671 3442 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1860 st056228 74.6 µM -0.565049724368017 0.284651610447712 no 2430 0.286019971669397 3447 688679
SGTC_3194 9111903 49.47 µM -0.565186159109728 0.284605407868101 no 2431 0.285973574950661 3505 17087251
SGTC_524 r073-0010 27.8 µM -0.565605566107746 0.28446340132994 no 2432 0.285830971597067 3401 2772106
SGTC_264 promethazine 12.5 mM -0.565673874383914 0.284440276114249 no 2433 0.285807749175632 3532 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.567828917710943 0.283711165129769 no 2434 0.285075571016846 3323 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1375 2910-0797 186 µM -0.568407945814609 0.283515416511662 no 2435 0.284878998148124 3394 742508
SGTC_3327 9140648 26.9345 µM -0.568821530694943 0.283375637946489 no 2436 0.284738630804683 3481 8029710
SGTC_2423 st077119 87.2 µM -0.5694102323089 0.283176732487998 no 2437 0.284538887219214 3434 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2146 5545642 200 µM -0.569442101867734 0.28316596658595 no 2438 0.284528075943116 3482 825326
SGTC_1491 4138-0063 26.5 µM -0.569464567688683 0.283158377492293 no 2439 0.284520454863803 3460 23883227
SGTC_1315 1237-0019 3.69 µM -0.569916030642348 0.283005891195209 no 2440 0.284367325778514 3487 825140
SGTC_1017 4239-0030 168 µM -0.571133922967485 0.282594732142899 no 2441 0.28395443252566 3392 1149593
SGTC_2756 carbadox 75.1 µM -0.572136501716077 0.282256478332156 no 2442 0.283614750915248 3422 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_588 3970-1144 52.9 µM -0.573148881983902 0.281915115475936 no 2443 0.283271946128666 3442 1888707
SGTC_850 0388-0143 75.9 µM -0.573721780870457 0.281722028796734 no 2444 0.283078043395899 3394 67273
SGTC_2483 5729050 27.16 µM -0.573832571821939 0.281684695783807 no 2445 0.283040552562963 3532 2865180
SGTC_1945 st075991 56.6 µM -0.574758095746405 0.281372917001616 no 2446 0.28272745530842 3409 1084980
SGTC_2372 9071633 200 µM -0.57615658999709 0.280902126167602 no 2447 0.282254671964379 3506 21321366
SGTC_3348 9149464 3.537 µM -0.576956956731069 0.280632861144265 no 2448 0.281984266478326 3475 1951442
SGTC_1111 tnp00062 510.699 nM -0.577668265811358 0.280393662378291 no 2449 0.281744054068084 3528 676306
SGTC_2648 atorvastatin 78.68 µM -0.577749164135943 0.280366464171552 no 2450 0.28171674057312 3503 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1882 5615643 20 µM -0.578312978109004 0.280176944075069 no 2451 0.281526416958056 3450 2253075
SGTC_221 trifluoperazine 10.304 µM -0.578370048103857 0.280157764060704 no 2452 0.281507155607847 3493 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1514 1189-1591 158 µM -0.580770450479071 0.27935161643049 no 2453 0.280697586509272 3533 767698 YMR146C TIF34
SGTC_1643 st009866 20.2 µM -0.580862720217064 0.279320651202461 no 2454 0.280666489746101 3484 3156273 YOR207C RET1
SGTC_2338 7999974 200 µM -0.582652889328117 0.278720210356675 no 2455 0.280063496692715 3525 315925
SGTC_792 4534-1957 155 µM -0.583326569649587 0.278494413993209 no 2456 0.279836739765197 3421 1717904
SGTC_3301 9125354 19.7965 µM -0.583976609883369 0.278276625553859 no 2457 0.279618024412468 3479 41905162
SGTC_2299 7976368 114.88 µM -0.584224883304114 0.278193466342395 no 2458 0.279534511165477 3466 2979718
SGTC_1627 st003713 25.6 µM -0.585299568938376 0.277833640088679 no 2459 0.279173152329856 3479 16195070 YER133W GLC7
SGTC_2044 5102272 200 µM -0.588852338757486 0.276645721418223 no 2460 0.277980166143251 3497 592666
SGTC_3115 9123671 49.47 µM -0.589222793734233 0.276521998028857 no 2461 0.277855914268558 3567 3286988
SGTC_2523 spermine 47.74 µM -0.589431357644063 0.276452354447153 no 2462 0.277785973146072 3475 1103 A DNA binding polyamine.
SGTC_65 0798-0905 34.986 µM -0.589833618323617 0.276318056011393 no 2463 0.277651100824874 3660 3602145
SGTC_71 0417-1750 47.813 µM -0.590079483917692 0.27623598727942 no 2464 0.277568681319869 3510 6811472
SGTC_2557 derrustone 83.84 µM -0.590709742186111 0.276025664800807 no 2465 0.277357459630655 3520 629853 An antioxidant.
SGTC_694 1315-0438 43.2 µM -0.591118668288948 0.275889244799699 no 2466 0.277220456178278 3421 6793154
SGTC_2894 9048625 32.47 µM -0.59164093773073 0.275715061015745 no 2467 0.277045527200477 3579 4092861
SGTC_1297 1068-0111 14.1 µM -0.593944568167658 0.274947415378152 no 2468 0.276274594325321 3450 767057
SGTC_1351 1496-0003 46.5 µM -0.596145566224775 0.274214955366709 no 2469 0.275538993055316 3520 3891978
SGTC_2898 9056270 58.44 µM -0.59650042787775 0.274096952865194 no 2470 0.275420484055133 3456 19154699
SGTC_147 4466-0538 29.23 µM -0.596643831867304 0.274049273711468 no 2471 0.275372600215893 3596 6742687 YHR072W ERG7
SGTC_2949 9072542 2.23 µM -0.596730988214191 0.274020297853006 no 2472 0.275343499955265 3518 16457352
SGTC_1834 st055981 52.8 µM -0.597084862673389 0.273902664876731 no 2473 0.275225361871359 3558 471719 YDL150W RPC53
SGTC_3261 9137475 49.47 µM -0.598581809590866 0.273405334455247 no 2474 0.274725894645307 3409 17027690
SGTC_2710 st078562 53.7235 µM -0.600002290365923 0.272933822174746 no 2475 0.274252354544323 3482 17250908
SGTC_3095 9117207 49.47 µM -0.600544809255152 0.272753845729295 no 2476 0.27407160358015 3485 17015229
SGTC_2698 st077697 67.5 µM -0.605951386767009 0.270963479337769 no 2477 0.272273517467868 3449 3154499
SGTC_1657 st012939 43.4 µM -0.606522505767891 0.270774698539988 no 2478 0.272083921099307 3547 24207257
SGTC_105 0111-0055 734.78 µM -0.607888204373768 0.270323539447869 no 2479 0.271630811688177 3489 5179370
SGTC_2016 5121758 140 µM -0.608603813329507 0.270087287873171 no 2480 0.271393538133117 3531 2795203
SGTC_3061 glucosamine 200 µM -0.608764190297897 0.270034355095944 no 2481 0.271340376313856 3485 91431 and experimental redox chemotherapeutic
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.609553159215082 0.269774029741742 no 2482 0.271078924178009 3499 5379071
SGTC_296 1222-0039 74.9 µM -0.610831874660727 0.269352376455554 no 2483 0.270655444610968 3500 5984176
SGTC_965 1291-5240 308 µM -0.610848320736974 0.269346955555316 no 2484 0.27065000022175 3539 2834598
SGTC_871 0574-0004 149 µM -0.611581590113089 0.269105313382482 no 2485 0.270407310751875 3452 9551173
SGTC_2047 4141938 200 µM -0.611770805517625 0.269042976849398 no 2486 0.270344703967239 3488 3807862
SGTC_3051 9093778 49.47 µM -0.611825918602976 0.269024821346778 no 2487 0.27032646974775 3520 17217378
SGTC_3148 9097893 49.47 µM -0.613213676626593 0.268567865106296 no 2488 0.269867531365896 3436 17174100
SGTC_2549 cedrol 20.94 µM -0.61369760039186 0.268408612123131 no 2489 0.269707587176992 3514 6708665 A sedative which affects the nervous system.
SGTC_2846 9008642 19.48 µM -0.613754945105922 0.268389743875068 no 2490 0.269688637020924 3534 2992898
SGTC_3053 9095903 49.47 µM -0.614712138148183 0.268074895222433 no 2491 0.269372421152478 3559 17174018
SGTC_107 0358-0022 2.6945 µM -0.616084241547452 0.267623894986807 no 2492 0.268919461016587 3507 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2124 5246320 200 µM -0.618201524762708 0.266928710907633 no 2493 0.268221252546695 3535 579342
SGTC_3086 9117350 49.47 µM -0.619118863795755 0.266627797320786 no 2494 0.267919028580971 3485 2679265
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.621175942750206 0.265953640370771 no 2495 0.26724193314656 3477 390807
SGTC_1751 st044839 27.194 µM -0.622045921771226 0.265668786250622 no 2496 0.266955836273781 3571 5291326
SGTC_1944 st076371 56.9 µM -0.623510127348841 0.265189716202519 no 2497 0.266474674623601 3458 24208455
SGTC_2202 7226349 200 µM -0.624778794532304 0.264774978921951 no 2498 0.266058125066844 3507 844334
SGTC_1401 3807-4679 7.6 µM -0.625014958991118 0.264697811327191 no 2499 0.265980620114635 3555 3291456
SGTC_1368 1852-0141 284 µM -0.626380028962392 0.264251993987447 no 2500 0.265532852800284 3537 2838987
SGTC_2918 7977171 22.06 µM -0.626609552690814 0.264177071546001 no 2501 0.265457602490528 3517 2236483
SGTC_3162 9099653 49.47 µM -0.627982587270392 0.263729103857535 no 2502 0.265007673473531 3546 25237511
SGTC_3297 9117502 71.43 µM -0.628606177339848 0.263525778726267 no 2503 0.264803457576278 3552 7453720
SGTC_2428 5615643 7.78 µM -0.629229604620813 0.26332258667043 no 2504 0.264599374993767 3554 2253075
SGTC_132 0417-1715 25.805 µM -0.629920540606443 0.263097485180664 no 2505 0.264373286554244 3614 6769098
SGTC_1962 st076595 64.5 µM -0.630058973393219 0.263052396698347 no 2506 0.264328000332379 3560 279619
SGTC_1395 3486-0190 4.35 µM -0.630184777658292 0.263011424835122 no 2507 0.264286848768749 3614 6748079
SGTC_996 3970-0799 1.8 µM -0.630806633426389 0.262808947114688 no 2508 0.264083482787019 3625 6615648 YGL040C HEM2
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.631114766933447 0.262708647655848 no 2509 0.263982743192493 3501 279621
SGTC_2078 5212016 200 µM -0.633705805475691 0.261866023129006 no 2510 0.263136417749708 3511 1899708
SGTC_2375 9072683 200 µM -0.634991208988518 0.261448515564113 no 2511 0.262717074256414 3631 16798029
SGTC_2216 7189485 200 µM -0.635785487652905 0.261190699567436 no 2512 0.26245812383069 3581 731273
SGTC_2038 4100038 30.985 µM -0.636638996821882 0.260913803556256 no 2513 0.262180008822931 3568 3596803
SGTC_168 3970-0862 530.542 µM -0.636676036435339 0.260901790559172 no 2514 0.262167942925927 3596 3135186
SGTC_1955 wogonin 32.4 µM -0.636964858744299 0.26080812705192 no 2515 0.262073866925139 3651 5281703 A flavanone.
SGTC_153 4077-0274 519.67 µM -0.637306209187909 0.260697451264078 no 2516 0.261962703628289 3678 3121976
SGTC_3187 9109394 49.47 µM -0.637812683544887 0.260533282026136 no 2517 0.26179781106485 3526 17098090
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.638676495721807 0.260253407717478 no 2518 0.261516703123745 3605 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_334 1502-1024 68.5 µM -0.638872673650968 0.260189867853031 no 2519 0.261452883097627 3590 3296216
SGTC_3173 9105693 49.47 µM -0.639644989183625 0.259939801101155 no 2520 0.261201713421085 3639 17096658
SGTC_3295 9122362 53.5725 µM -0.641283420763715 0.259409706817211 no 2521 0.260669279439574 3575 4730473
SGTC_3321 9137793 26.8275 µM -0.641699895608153 0.259275050599229 no 2522 0.260534028515363 3577 4904192
SGTC_2101 5377231 179.231 µM -0.642014068109245 0.259173495068382 no 2523 0.260432024367948 3579 2844213
SGTC_1662 st014054 52 µM -0.644725848204205 0.258297773961286 no 2524 0.259552431284346 3581 2838777
SGTC_1506 4226-2149 212 µM -0.645963834704896 0.257898498701635 no 2525 0.259151388547864 3590 991114
SGTC_1201 1889-3372 45.9 µM -0.646257411606665 0.257803861310336 no 2526 0.259056332032126 3532 5392199
SGTC_1217 1183-1422 255 µM -0.646474337323175 0.257733944760629 no 2527 0.258986105792958 3603 2849664
SGTC_2414 st077232 92.9 µM -0.647081485723207 0.257538309277558 no 2528 0.258789603545885 3542 729801
SGTC_1262 0737-0114 49.6 µM -0.647490411884195 0.257406588486729 no 2529 0.258657298988584 3632 765919
SGTC_2656 pseudo-anisatin 100 µM -0.647792424691129 0.257309328448863 no 2530 0.25855960781775 3601 6708809 A neurotoxin.
SGTC_2420 aureobasidin a 50 nM -0.64903052950083 0.256910809596617 no 2531 0.258159321606996 3653 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1990 st072050 59.8 µM -0.649201421303403 0.256855828498701 no 2532 0.258104096575806 3598 17233948
SGTC_2265 7929201 200 µM -0.652276261772514 0.255867605966104 no 2533 0.257111485403528 3604 1265108
SGTC_85 0868-0259 160.055 µM -0.654194596453949 0.255252079331524 no 2534 0.256493221217743 3531 83173
SGTC_2956 9076196 2.52 µM -0.65424713612684 0.255235232082981 no 2535 0.256476298997694 3644 16423868
SGTC_2920 7982904 15.77 µM -0.654552154696322 0.255137437028537 no 2536 0.256378068702293 3565 6456808
SGTC_1546 5-methoxyflavanone 78.7 µM -0.654793732127394 0.255059996381145 no 2537 0.256300283346759 3634 147795
SGTC_1128 3448-9350 235 µM -0.654802763841657 0.255057101391367 no 2538 0.256297375469693 3565 619386
SGTC_134 0269-0018 6.916 µM -0.655916311728373 0.254700300926582 no 2539 0.255938986154982 3527 4378915
SGTC_2790 5423970 71.43 µM -0.656694806765439 0.254451012652403 no 2540 0.25568858717263 3624 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_254 nsc-64875 3.808 µM -0.657709730504418 0.254126207705198 no 2541 0.255362334292656 3624 56993
SGTC_301 4119-0100 24.5 µM -0.658371151633092 0.253914650915208 no 2542 0.25514983395213 3612 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3027 9089541 49.47 µM -0.661408281818559 0.252944407032692 no 2543 0.254175258091811 3599 9943819
SGTC_2597 laccaic acid a 100 µM -0.66192381043152 0.252779909789637 no 2544 0.254010025638658 3585 5491415 A textile dye.
SGTC_1273 0849-0096 14.1 µM -0.661924091253671 0.252779820198964 no 2545 0.254009935647506 3622 5286025
SGTC_1248 0469-0687 58.6 µM -0.663013060319528 0.252432532234461 no 2546 0.253661094780889 3606 4017482
SGTC_173 1273-0061 2.693 µM -0.663255749785952 0.25235516933736 no 2547 0.253583385821669 3569 2847414 YPL266W DIM1
SGTC_605 1315-0399 119 µM -0.663963440337452 0.252129647937186 no 2548 0.253356855335694 3662 24020461
SGTC_1635 st007035 42.4 µM -0.666059519956809 0.251462309586005 no 2549 0.252686528598223 3638 3716403
SGTC_2106 5357045 167.29 µM -0.668948456842824 0.250544077756601 no 2550 0.251764178986 3632 668842
SGTC_3316 9136639 10.545 µM -0.671774486643541 0.24964756240482 no 2551 0.250863636683177 3632 4903665
SGTC_2700 st077718 96.8 µM -0.671845748691533 0.249624977640251 no 2552 0.25084095038928 3618 904970
SGTC_2765 myclobutanil 7.74 µM -0.672992273420011 0.24926176389285 no 2553 0.250476103259144 3649 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.673478803168085 0.249107718480002 no 2554 0.250321364779589 3606 689007
SGTC_2368 9071271 200 µM -0.673829911803451 0.248996581669442 no 2555 0.250209727834387 3621 27209959
SGTC_879 0831-1030 162 µM -0.674372857276678 0.248824774487396 no 2556 0.250037147295599 3659 1549252
SGTC_1827 berberine 7.24 µM -0.674676045169085 0.24872886256526 no 2557 0.249940803541528 3562 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1729 st035615 45.989 µM -0.675311498757294 0.248527903997189 no 2558 0.24973893994238 3614 17385451
SGTC_2986 9022445 71.43 µM -0.675410205032583 0.24849669646556 no 2559 0.24970759183639 3603 6459286
SGTC_3237 9133362 49.47 µM -0.67899603083968 0.24736439877833 no 2560 0.248570188438337 3593 43845137
SGTC_2079 5212404 121 µM -0.680311224548461 0.246949791829003 no 2561 0.248153709395919 3644 758462
SGTC_769 0302-0231 76 µM -0.680323724731118 0.246945853006009 no 2562 0.248149752781201 3652 571869 YER009W NTF2
SGTC_1151 3909-8316 15.3 µM -0.680820673246296 0.246789291154388 no 2563 0.247992483637016 3663 800431
SGTC_1363 1636-0063 10.4 µM -0.681097960835708 0.246701955794881 no 2564 0.247904753641427 3678 6072185
SGTC_575 k072-0246 11.9 µM -0.681993373853008 0.246420046782495 no 2565 0.247621570371703 3663 6796779
SGTC_52 0329-0193 875 nM -0.682449915727858 0.246276377056384 no 2566 0.247477251000131 3712 3739292
SGTC_1698 5-fluorocytosine 1.055 µM -0.682512356876067 0.24625673086597 no 2567 0.247457515960831 3668 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1379 2144-0755 36.5 µM -0.682921162145178 0.246128127052733 no 2568 0.247328330467511 3674 5392327
SGTC_1520 flindersine 88 µM -0.684570786606333 0.245609546867859 no 2569 0.246807403388019 3711 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2217 6934799 96.0675 µM -0.684891106582269 0.245508918340198 no 2570 0.246706319206415 3601 675606
SGTC_623 k072-0108 16.9 µM -0.685740892240692 0.245242065517685 no 2571 0.246438257663353 3635 5382803
SGTC_2339 9000433 200 µM -0.686157532004951 0.245111287758144 no 2572 0.246306887334081 3631 2988954
SGTC_2947 9072639 7.68 µM -0.686370363190025 0.245044497315948 no 2573 0.24623979420396 3659 16488146
SGTC_129 0088-0017 176.636 µM -0.6868396730366 0.244897253632058 no 2574 0.246091883100577 3580 182446
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.687475960875816 0.244697697476032 no 2575 0.245891422130762 3665 115019
SGTC_186 3455-3465 67.277 µM -0.687869858846188 0.244574204879602 no 2576 0.245767369444419 3617 755278
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.687997049005176 0.244534336132931 no 2577 0.245727319850689 3611 4620898
SGTC_3038 9091290 49.47 µM -0.688446144955014 0.244393591515542 no 2578 0.245585936706362 3682 25236843
SGTC_703 3875-0075 71.8 µM -0.688774507730753 0.24429071175672 no 2579 0.245482590105661 3692 2850814
SGTC_788 1182-0090 188 µM -0.692690854255307 0.243065477798327 no 2580 0.244251789908685 3760 5715185
SGTC_3354 9151612 71.43 µM -0.693113601516037 0.242933419805189 no 2581 0.244119131267351 3664 27261949
SGTC_1462 k081-0014 26.5 µM -0.694243936171113 0.242580516045328 no 2582 0.243764621696137 3467 3270634
SGTC_761 k216-0224 480 µM -0.694446612288352 0.242517267545145 no 2583 0.243701085293641 3705 1340404
SGTC_2480 5767542 37.17 µM -0.694726967039183 0.242429792842127 no 2584 0.2436132123605 3667 2867358
SGTC_1719 st032227 49.2 µM -0.697720428466634 0.241496856441125 no 2585 0.242676024999524 3691 3125804
SGTC_2944 9067346 25.62 µM -0.698238988935877 0.241335441262823 no 2586 0.242513873631669 3616 6473075
SGTC_1979 st071809 45.3 µM -0.699796654443357 0.240850930829615 no 2587 0.242027152191775 3734 4976333
SGTC_277 nystatin 15.5 µM -0.699928758048912 0.240809864481279 no 2588 0.241985898357198 3668 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2849 9019321 12.99 µM -0.699929765462682 0.240809551326533 no 2589 0.24198558377271 3648 16489627
SGTC_533 1222-0222 6.71 µM -0.700238649064797 0.240713545254984 no 2590 0.241889139338627 3759 3982874
SGTC_3279 9140807 49.47 µM -0.700846412588716 0.240524703252857 no 2591 0.241699434875189 3708 45595718
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.701027192946721 0.240468547428538 no 2592 0.241643022527338 3679 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1055 3448-0672 86 µM -0.702137517794461 0.24012380373689 no 2593 0.241296703481792 3656 748378
SGTC_1615 st002656 86.5 µM -0.703973098326971 0.239554467436821 no 2594 0.240724763482435 3692 1584458
SGTC_1688 st021091 57.6 µM -0.703977383837403 0.239553139076227 no 2595 0.240723429043991 3694 3656366
SGTC_421 streptovitacin 30 mM -0.704485662255453 0.239395618802489 no 2596 0.240565187945969 3729 91467 include heat shock
SGTC_3106 9121286 49.47 µM -0.704520898304745 0.239384700915782 no 2597 0.240554220091023 3697 15943471
SGTC_2610 ononetin 44.17 µM -0.70724516207152 0.238541411878624 no 2598 0.239707068732068 3690 259632
SGTC_1709 st033179 39.1045 µM -0.70883434193404 0.238050237199528 no 2599 0.239213641881783 3675 573381
SGTC_1412 3909-8563 178 µM -0.709164993528682 0.237948110995719 no 2600 0.239111047165113 3759 23767530
SGTC_2123 5259487 200 µM -0.712650503663785 0.236873026712305 no 2601 0.238031025915352 3675 2173474
SGTC_2841 9004761 38.96 µM -0.713616747005941 0.236575468341425 no 2602 0.237732099520097 3639 2991039
SGTC_1981 st071826 47 µM -0.714034338176851 0.236446933205774 no 2603 0.237602973231804 3674 11838600
SGTC_838 0109-0203 71.4 µM -0.714246929102311 0.236381512195296 no 2604 0.237537251290948 3702 759422
SGTC_1210 3013-0140 750 nM -0.714272221168873 0.2363737296828 no 2605 0.237529432977432 3717 905973
SGTC_3226 9131256 49.47 µM -0.714921249777994 0.236174068155597 no 2606 0.237328852809154 3602 17178073
SGTC_2635 hydroquinidine 100 µM -0.715840521380635 0.235891430455843 no 2607 0.237044914167566 3668 442912 An experimental heart treatment.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.717595455674961 0.235352379395485 no 2608 0.236503380216359 3698 688798
SGTC_2978 9011784 42.97 µM -0.717981451178123 0.235233907109946 no 2609 0.236384361941519 3761 2994934
SGTC_2117 5521686 200 µM -0.718216528988698 0.235161771614947 no 2610 0.236311893951015 3682 803312
SGTC_994 3910-0338 138 µM -0.72058417546534 0.234435922023759 no 2611 0.235582696451578 3784 3479481
SGTC_164 4100-3994 89.624 µM -0.720863768401036 0.234350289104739 no 2612 0.235496668291307 3724 4615967
SGTC_3119 9125183 49.47 µM -0.72241808154548 0.233874554301685 no 2613 0.235018736691538 3592 22695334
SGTC_492 tmb-8 126 µM -0.723794639356531 0.233453673000332 no 2614 0.234595910437739 3604 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1558 st069300 45.6 µM -0.724383733312139 0.233273686513302 no 2615 0.234415091791747 3663 24208000
SGTC_2054 5233173 129 µM -0.724443623769619 0.233255392433354 no 2616 0.234396713116054 3732 6889
SGTC_1602 st001878 87.6 µM -0.724523486117088 0.233230998998485 no 2617 0.234372206876716 3724 595405 YLR310C CDC25
SGTC_3144 9087057 49.47 µM -0.72467709666414 0.23318408363657 no 2618 0.234325074547574 3630 17249618
SGTC_2252 omeprazole 400 µM -0.725225758210337 0.233016555532314 no 2619 0.234156771546163 3652 4594 A proton pump inhibitor.
SGTC_376 3970-0862 59.1 µM -0.726311636794004 0.2326851909195 no 2620 0.233823873579957 3718 3135186
SGTC_842 0271-0008 11.1 µM -0.726534894682383 0.232617094448108 no 2621 0.233755461895275 3768 1221709
SGTC_1919 st067113 52.3 µM -0.728836996593159 0.231915570788114 no 2622 0.233050688867889 3748 1268243
SGTC_447 ml7 120 µM -0.729729429567725 0.231643935320161 no 2623 0.232777794207559 3738 4216 Selective myosin light chain kinase inhibitor.
SGTC_2363 9053361 176 µM -0.731124573166189 0.231219642122192 no 2624 0.232351533028951 3750 6469797 YMR079W SEC14
SGTC_2886 9058944 51.95 µM -0.731783162448631 0.231019501692598 no 2625 0.232150463819465 3604 4949929
SGTC_1977 st070720 65.3 µM -0.734821077692468 0.23009755453576 no 2626 0.231224234292263 3750 682188
SGTC_1157 4092-0394 27.6 µM -0.736616438755042 0.229553667228213 no 2627 0.230677817637141 3811 3659885
SGTC_2715 st079500 56.4 µM -0.73754189473852 0.229273590852329 no 2628 0.230396437889347 3688 28246688
SGTC_63 0099-0242 26.702 µM -0.737616808749617 0.229250927554642 no 2629 0.230373669099002 3783 3898502 YLR359W ADE13
SGTC_1581 himbacine 57.9 µM -0.73788497659827 0.229169810600686 no 2630 0.230292174531548 3739 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_702 1488-0190 94 µM -0.738716592013269 0.228918361171016 no 2631 0.230039554243901 3763 949357
SGTC_1096 rimcazole 32.2 µM -0.738754651970387 0.2289068569683 no 2632 0.230027996461138 3677 18528119 A dopamine reuptake inhibitor.
SGTC_687 k029-0044 34.9 µM -0.7392249739943 0.228764721741161 no 2633 0.229885199166 3750 5829338
SGTC_2568 diosmetin 100 µM -0.739958952922058 0.228543006232486 no 2634 0.229662450597499 3733 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1853 st056710 91.2 µM -0.740188844703647 0.228473586872465 no 2635 0.229592707708804 3822 269167
SGTC_1818 st052136 56.3 µM -0.74340419761893 0.227503904028111 no 2636 0.228618501849553 3629 674169
SGTC_1383 3049-0032 20.7 µM -0.743869922078858 0.227363643748101 no 2637 0.228477586747504 3769 712864
SGTC_1649 st011737 51.3 µM -0.745510488574405 0.226869949490115 no 2638 0.227981586437777 3758 1761035
SGTC_425 3825-7017 13.1 µM -0.745664329071378 0.226823685433543 no 2639 0.227935106187089 3844 3397440
SGTC_791 1348-1292 225 µM -0.745739381890641 0.226801116924258 no 2640 0.227912432208245 3734 5437054
SGTC_711 k292-0785 179 µM -0.746746976756836 0.226498254149021 no 2641 0.227608153691314 3752 4146315
SGTC_2587 piperic acid 92.2 µM -0.747122492331025 0.226385440146845 no 2642 0.227494812159985 3762 5370536
SGTC_2187 6125751 200 µM -0.747661329855575 0.22622361571587 no 2643 0.227332230855188 3759 874498
SGTC_1241 0364-0022 50.8 µM -0.748501001018217 0.225971574833359 no 2644 0.227079010752666 3773 4563895
SGTC_2478 5763493 32.33 µM -0.749775173029779 0.225589414898473 no 2645 0.226695061901226 3716 1365576 YLR208W SEC13
SGTC_2842 9000675 19.48 µM -0.750843642722868 0.225269232994689 no 2646 0.226373380360369 3750 2989072
SGTC_2663 amphotericin b 100 µM -0.752606352318264 0.224741575341213 no 2647 0.225843249638308 3755 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2727 riluzole 51.77 µM -0.75263887651955 0.224731845986258 no 2648 0.225833474663447 3756 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_320 4092-0846 5.34 µM -0.753072031024898 0.224602294052618 no 2649 0.225703315207125 3743 1359356
SGTC_2863 9028737 58.44 µM -0.755688154898765 0.223820740320682 no 2650 0.224918093784195 3765 6460917
SGTC_1339 1486-1321 22.7 µM -0.756214079653191 0.223663809788809 no 2651 0.224760426255679 3799 3469382
SGTC_2697 mebhydrolin 72.4 µM -0.757550260608192 0.223265388673794 no 2652 0.224360133200993 3763 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_108 0509-0257 621.132 µM -0.758058341555235 0.223113995669714 no 2653 0.224208028582705 3744 536624
SGTC_32 0928-0142 34.1 µM -0.758295843198049 0.223043247299465 no 2654 0.224136947605251 3723 2244242
SGTC_212 3807-4682 38.772 µM -0.758834086210221 0.222882959635145 no 2655 0.22397590624749 3864 3125501 YBL034C STU1
SGTC_897 1000-0139 31.4 µM -0.759897037894687 0.222566607650349 no 2656 0.223658066173689 3735 6151020
SGTC_906 1165-0455 526 µM -0.760840644418368 0.222285989389696 no 2657 0.22337612728943 3745 3252859
SGTC_3081 9117243 49.47 µM -0.76090890769624 0.222265696470392 no 2658 0.223355738846506 3788 45595589
SGTC_526 4469-0568 170 µM -0.76111148124822 0.222205482779119 no 2659 0.223295241697002 3756 2901964
SGTC_2099 5377090 177.372 µM -0.762394246789388 0.221824405110668 no 2660 0.222912369467016 3777 2243829
SGTC_403 arphamenine a 50 µM -0.763137883163097 0.221603660318043 no 2661 0.222690584655882 3745 5487158 An arginine aminopeptidase inhibitor.
SGTC_2340 7987427 183.45 µM -0.763254086137603 0.221569177382863 no 2662 0.222655939224956 3771 2239331
SGTC_1191 1487-1166 10.6 µM -0.763923577383316 0.22137056731333 no 2663 0.222456393063322 3836 3955771
SGTC_3158 9100007 49.47 µM -0.765066993716459 0.221031598996218 no 2664 0.222115826440977 3799 19297233
SGTC_438 sphingosine 6.67 µM -0.765477991730042 0.220909830334218 no 2665 0.221993483407231 3741 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3195 9113082 49.47 µM -0.765517273662855 0.220898194069018 no 2666 0.221981792249083 3702 17018038
SGTC_2629 bisabolol 100 µM -0.766437101452276 0.22062581900223 no 2667 0.221708131993634 3792 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3319 9138450 16.7555 µM -0.766571994212555 0.22058589137696 no 2668 0.221668015925726 3737 2029690
SGTC_3272 9137413 49.47 µM -0.766656952113016 0.220560746361251 no 2669 0.221642752229422 3735 17614870
SGTC_2068 5226020 147 µM -0.766779924650507 0.220524353050965 no 2670 0.221606187140059 3829 1810509
SGTC_2645 abamectin 100 µM -0.767006150268881 0.220457411325938 no 2671 0.221538929419675 3747 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1556 plumbagin 1.48 µM -0.767062354549378 0.220440781896905 no 2672 0.221522221487052 3702 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_312 4092-0653 6.84 µM -0.768461011247392 0.220027186269304 no 2673 0.221106672716232 3773 1148278
SGTC_1989 st071868 50.2 µM -0.768674376581147 0.21996413134185 no 2674 0.22104331991055 3766 16414057
SGTC_844 0330-0132 15.3 µM -0.769421461809285 0.219743430229157 no 2675 0.220821575951467 3811 2828079
SGTC_1211 1056-0033 32.3 µM -0.769543221571568 0.219707472469503 no 2676 0.220785448251933 3774 6741922
SGTC_2018 5133068 143 µM -0.77070620202348 0.219364194543702 no 2677 0.220440547482078 3779 785362
SGTC_2871 9038510 12.99 µM -0.772194293953327 0.218925402996159 no 2678 0.219999680288751 3764 4945164
SGTC_2639 lactacystin 53 µM -0.773268403420172 0.218608995857653 no 2679 0.219681775550352 3809 3870 A proteasome inhibitor.
SGTC_768 0384-0033 77.3 µM -0.7740727330148 0.218372231940319 no 2680 0.219443890515374 3777 3965305 YMR134W ERG29
SGTC_2745 rifampicin 24.3 µM -0.774210858722549 0.21833158787238 no 2681 0.219403053949492 3750 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1150 3909-7983 10.9 µM -0.77489141092135 0.21813139618011 no 2682 0.219201913935106 3781 23965914
SGTC_3289 9119912 71.43 µM -0.776144615579714 0.21776302957012 no 2683 0.218831801579804 3793 17014829
SGTC_1999 st074831 12.5 µM -0.777067299122391 0.217492045759518 no 2684 0.218559532902055 3787 17112523
SGTC_1961 st076550 68.7 µM -0.778868419055801 0.216963634351096 no 2685 0.218028614492994 3796 1579337
SGTC_783 0848-0141 92.7 µM -0.779061728620474 0.216906965441839 no 2686 0.217971676602174 3777 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_735 3076-0345 636 µM -0.779685888292115 0.216724050777732 no 2687 0.217787893565484 3837 2888990
SGTC_669 0108-0021 26.2 µM -0.779913722958644 0.21665730435357 no 2688 0.21772083020733 3807 17201
SGTC_1612 st002233 45.4 µM -0.780636977122469 0.216445498674333 no 2689 0.21750801859009 3808 1035021
SGTC_2376 9072922 81.32 µM -0.781328677274951 0.216243045762683 no 2690 0.217304603854596 3834 17087968
SGTC_2223 6903751 107.57 µM -0.783347025802513 0.215652924781781 no 2691 0.216711677595271 3760 5598863
SGTC_3012 9080433 71.4286 µM -0.783637376559739 0.215568109457354 no 2692 0.216626458873348 3796 17688859
SGTC_2835 9006588 71.43 µM -0.783842628393157 0.215508164334968 no 2693 0.216566228609286 3869 2345538
SGTC_799 1310-0557 151 µM -0.785887284293194 0.214911537479111 no 2694 0.215966762350672 3877 5354492
SGTC_782 0083-0095 30.5 µM -0.786926349085749 0.214608708290925 no 2695 0.215662490983434 3797 3591729 An indicator and reagent.
SGTC_3065 9113888 49.47 µM -0.790426366576593 0.21359047583148 no 2696 0.214639404480976 3850 16648368
SGTC_1214 0358-0031 63.7 µM -0.791165339881838 0.213375852619522 no 2697 0.214423757178326 3961 4301366
SGTC_569 4130-2812 160 µM -0.791370210253896 0.213316373497635 no 2698 0.214363994188633 3675 743552
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.79231900266767 0.213041040811077 no 2699 0.214087347127835 3843 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_566 0958-0068 16.5 µM -0.79348333435118 0.212703443685007 no 2700 0.213748137647211 3764 6815365
SGTC_3015 9080845 49.47 µM -0.793867434555576 0.212592142665891 no 2701 0.213636304877927 3898 5296973
SGTC_3102 9121669 49.47 µM -0.794879628550249 0.212299001388481 no 2702 0.213341762667175 3832 41905072
SGTC_196 k015-0023 18.111 µM -0.794939455235069 0.212281682392912 no 2703 0.213324360884167 3783 5211998
SGTC_182 3448-4371 550.524 µM -0.795183469878936 0.212211052090657 no 2704 0.213253392936018 3795 3491403
SGTC_1049 3226-0134 66 µM -0.795813351311189 0.21202879573955 no 2705 0.213070265148976 3854 5702385
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.796716339244997 0.211767675697843 no 2706 0.212807896179518 3797 15053
SGTC_590 k048-0076 22.4 µM -0.797809743254131 0.21145174442312 no 2707 0.212490453164078 3816 6832814
SGTC_2200 6600604 21.907 µM -0.799988014680568 0.210823171766866 no 2708 0.211858870645839 3792 2904777
SGTC_1270 0831-1170 17.3 µM -0.802186212163101 0.210189961444715 no 2709 0.211222625403349 3833 6764716
SGTC_883 0850-0245 24.6 µM -0.804659198534217 0.209478932678791 no 2710 0.210508185337535 3933 6823229 YPR165W RHO1
SGTC_1607 st000305 50.6 µM -0.804870968971346 0.20941811065623 no 2711 0.210447071342554 3824 5457690
SGTC_1848 st056003 16.4 µM -0.806104918565703 0.209063918008627 no 2712 0.210091177893015 3875 146492
SGTC_1933 st074711 15.9 µM -0.806916388208702 0.208831186322821 no 2713 0.209857328165737 3827 17250958
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.806982794268902 0.20881214764496 no 2714 0.20983819800921 3863 6710655
SGTC_749 1000-0129 128 µM -0.80912893998445 0.208197396546238 no 2715 0.209220491722735 3887 708470
SGTC_930 2810-3379 265 µM -0.810228177653293 0.207882940259241 no 2716 0.20890452277081 3862 1015764
SGTC_1617 st002906 78 µM -0.810287553838276 0.207865962643822 no 2717 0.208887463466163 3851 5150859
SGTC_1968 st069590 43.6 µM -0.811086532758843 0.207637587790505 no 2718 0.208657989570248 3844 6384066
SGTC_2479 5617353 43.85 µM -0.811105147778589 0.207632268764121 no 2719 0.20865264494193 3869 2731746
SGTC_3070 9117005 49.47 µM -0.813361155849294 0.206988236880682 no 2720 0.208005511682614 3879 8779016
SGTC_1735 st034310 56.75 µM -0.814112282839121 0.206774072157098 no 2721 0.20779031498846 3971 871153
SGTC_188 3229-0966 278.469 µM -0.814570113575468 0.206643597762445 no 2722 0.207659211733988 3894 5722370
SGTC_2789 5281112 71.43 µM -0.814592201528318 0.20663730428431 no 2723 0.207652887919554 3873 765948
SGTC_1277 0873-0036 22 µM -0.815525668769028 0.206371437029077 no 2724 0.207385738856791 3899 5965735
SGTC_2647 atorvastatin 60.16 µM -0.815569654624152 0.206358914116642 no 2725 0.207373155556259 3845 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_894 0960-0238 55.9 µM -0.816321755300183 0.206144858356025 no 2726 0.20715806740394 3804 6741907 YDL195W SEC31
SGTC_2417 cerulenin 830 nM -0.817375802831599 0.205845086978656 no 2727 0.206856849688088 3894 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1877 wortmannin 25 µM -0.817710956466905 0.205749823421559 no 2728 0.20676112637105 3862 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1198 1612-1005 86.7 µM -0.817961940709869 0.205678501178946 no 2729 0.206689459872207 3931 6998509
SGTC_773 4358-1457 44.6 µM -0.818205631127945 0.205609265666511 no 2730 0.206619890141652 3835 1186886
SGTC_2723 salbutamol 83.58 µM -0.818231279993898 0.205601979305925 no 2731 0.206612568605927 3832 9884233 β2-adrenoceptor agonist
SGTC_1508 1080-0625 72.9 µM -0.818602906746572 0.205496424333462 no 2732 0.206506504021768 3763 767111
SGTC_1817 st052116 64.4 µM -0.819127623813139 0.20534744117005 no 2733 0.206356801445896 3839 4361398
SGTC_2987 9018338 71.43 µM -0.819757118621337 0.205168793090994 no 2734 0.206177290503329 3899 5055682
SGTC_300 r073-0011 5.04 µM -0.821989316063752 0.204536049288793 no 2735 0.205541488779941 3860 2735780
SGTC_866 0495-0101 262 µM -0.822010417792464 0.204530073290446 no 2736 0.205535483887506 3831 635694
SGTC_853 0419-0306 21 µM -0.823168392118111 0.204202294899602 no 2737 0.205206120299671 3878 762713
SGTC_2015 5119600 184 µM -0.823419735647389 0.204131190469439 no 2738 0.205134671896582 3895 2828786
SGTC_2730 imipramine 71.33 µM -0.823569301750506 0.204088885607928 no 2739 0.205092162365491 3860 3696 A tricyclic antidepressant.
SGTC_250 brefeldin a 552.239 µM -0.824297094224884 0.203883103622412 no 2740 0.204885384635703 3736 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_417 st075190 100 µM -0.825611763542092 0.203511696871933 no 2741 0.204512179965772 3858 222757
SGTC_2140 5586273 200 µM -0.825666185336358 0.203496330894341 no 2742 0.204496739583355 3824 854421
SGTC_1229 0139-0193 12.2 µM -0.825723303858759 0.203480204240718 no 2743 0.204480534839815 3900 3090752
SGTC_2210 7115885 190.385 µM -0.826351489398839 0.203302894727197 no 2744 0.204302366623398 3911 2927039
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.828613016953518 0.202665327547101 no 2745 0.203661709930437 3940 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2057 5236571 38.335 µM -0.829559221281728 0.202398929688042 no 2746 0.203394020331546 3852 54684039 YBR257W POP4
SGTC_1033 k072-0102 21.3 µM -0.832966694361646 0.201441313432634 no 2747 0.202431756632942 3829 5965931
SGTC_2963 9082507 9 µM -0.835252615929896 0.200800415892631 no 2748 0.201787745201708 3927 16459611
SGTC_1030 k029-0042 36.7 µM -0.835933969113764 0.2006096237716 no 2749 0.201596025545178 3876 6080581
SGTC_1203 3992-3522 103 µM -0.836171383852882 0.200543168614175 no 2750 0.201529247257497 3974 5322312
SGTC_1949 st076024 69.1 µM -0.836946231239368 0.200326371780261 no 2751 0.201311396064377 3830 2921930
SGTC_7 0192-1582 4.227 µM -0.837005902032622 0.200309682154503 no 2752 0.201294625257749 3925 252616
SGTC_1004 4084-0029 199 µM -0.837715434297634 0.200111293522548 no 2753 0.201095271487272 3919 716894 YLR208W SEC13
SGTC_500 h-89 112 µM -0.839085749300786 0.199728481327362 no 2754 0.200710596192171 3914 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_828 2074-0507 139 µM -0.840988814316603 0.199197571092575 no 2755 0.200177100425027 3973 X828
SGTC_1483 3453-0561 55.9 µM -0.841423022403889 0.199076556485678 no 2756 0.200055496207938 3909 4546991
SGTC_2257 7960413 200 µM -0.841898377858432 0.198944124831548 no 2757 0.199922419202822 3880 2974689 YIL048W NEO1
SGTC_1415 3966-0071 78.1 µM -0.842560125069233 0.198759853793582 no 2758 0.199737249997265 3831 2893185
SGTC_3039 9090270 49.47 µM -0.84263845425623 0.198738048953796 no 2759 0.199715338861777 3860 17173750
SGTC_377 3970-0964 33.1 µM -0.846819857540409 0.197576147947071 no 2760 0.198547769068561 3876 16481235
SGTC_3125 9127534 49.47 µM -0.847261312672462 0.197453719394448 no 2761 0.19842474266729 3760 1639235
SGTC_558 k064-0027 21.3 µM -0.849468991810191 0.196842153357264 no 2762 0.197810188684853 3932 5088526
SGTC_3216 9129716 49.47 µM -0.8498502699164 0.196736648865795 no 2763 0.197704168471562 3882 8056934
SGTC_1407 3909-7909 12.3 µM -0.852194057216778 0.196088845840441 no 2764 0.197053197242231 3884 4411780
SGTC_3135 9127742 49.47 µM -0.852907744630342 0.195891845902908 no 2765 0.196855233278649 3989 3643468
SGTC_564 3555-0129 330 µM -0.854576274836747 0.195431748446032 no 2766 0.196392883302837 3777 563260
SGTC_650 1328-0195 38 µM -0.855534518373454 0.19516780962594 no 2767 0.196127651664735 3843 2780821
SGTC_584 0986-0246 15.4 µM -0.855748438277159 0.195108917071833 no 2768 0.196068470580974 4004 53315 YDR232W HEM1
SGTC_1994 st072947 40.9 µM -0.858912650749799 0.194239065474738 no 2769 0.195194354655433 3978 5286565 YDL195W SEC31
SGTC_3139 9095020 49.47 µM -0.85916047574248 0.194171037509394 no 2770 0.195125992979104 3638 25236292
SGTC_1825 st052143 62.6 µM -0.860465492209986 0.193813049932316 no 2771 0.194766248786403 3928 674173
SGTC_895 0964-0006 13.7 µM -0.864410373044633 0.192733352576948 no 2772 0.193681248279685 3902 6738897
SGTC_2493 resveratrol 26.09 µM -0.865736511831678 0.192371220930754 no 2773 0.193317336218184 3800 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3050 9093513 49.47 µM -0.865822080975907 0.19234786867431 no 2774 0.193293869120883 3913 25236664
SGTC_2166 5933061 31.504 µM -0.86750418378923 0.191889166283875 no 2775 0.192832910209714 4011 2877375
SGTC_1465 k213-0056 144 µM -0.867564706109399 0.191872674590427 no 2776 0.192816337361846 3803 24048857 YMR208W ERG12
SGTC_1282 0886-0010 32.4 µM -0.86810476013403 0.191725553986443 no 2777 0.192668492708647 3992 2836211 YNL267W PIK1
SGTC_1386 3228-0095 33.8 µM -0.869645173328434 0.191306296900941 no 2778 0.192247171480007 3952 870181
SGTC_1791 st048313 56.1 µM -0.874998088658959 0.189853758536172 no 2779 0.190787472842829 3919 1204976
SGTC_2877 9040724 71.43 µM -0.87541822141865 0.189740041289402 no 2780 0.190673194444313 3896 6463895
SGTC_681 1642-0006 26.6 µM -0.875765909276486 0.189645964374952 no 2781 0.190578653231846 3942 4446530
SGTC_2718 lomofungin 53.02 µM -0.876262964110654 0.189511521785804 no 2782 0.19044354702749 3899 5351222 A RNA synthesis inhibitor.
SGTC_2293 7624732 200 µM -0.877092849904029 0.189287186351909 no 2783 0.190218104000111 3840 894453
SGTC_1891 st059073 26.2 µM -0.877261212177006 0.189241694474537 no 2784 0.190172387479262 4022 688754
SGTC_313 3474-0040 5.03 µM -0.877451875537448 0.189190184920129 no 2785 0.190120623549185 3943 1043375 YIL048W NEO1
SGTC_2085 5307070 144.047 µM -0.877698059785849 0.189123688631164 no 2786 0.190053798848221 3890 2840351
SGTC_475 α-linolenic acid 10 µM -0.88354220135299 0.187549369308055 no 2787 0.188471695874506 3968 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1708 st033234 31.827 µM -0.885422566778184 0.187044555510255 no 2788 0.187964382807138 4042 674664
SGTC_1255 0566-0045 221 µM -0.885679467215365 0.186975651852259 no 2789 0.187895137888159 4003 2788469
SGTC_2122 5258151 111.688 µM -0.886798437368282 0.186675714368748 no 2790 0.187593714539579 3945 2173356
SGTC_3253 9135987 49.47 µM -0.887240257487811 0.186557367532083 no 2791 0.187474781263153 3936 4182430
SGTC_2228 7354201 200 µM -0.887874667067929 0.186387514565481 no 2792 0.187304086472788 3964 753451
SGTC_143 4032-1194 15.74 µM -0.888328306659613 0.186266118618845 no 2793 0.187182088750918 3964 1806963
SGTC_941 3237-0776 460 µM -0.890422237733881 0.18570640869429 no 2794 0.186619603048249 4000 760008
SGTC_633 0437-0093 97.7 µM -0.890954061520818 0.185564417977161 no 2795 0.186476907834776 3896 2831118
SGTC_2787 5284540 71.43 µM -0.891098841428648 0.185525775108927 no 2796 0.186438073215032 4009 736958
SGTC_219 mitoxanthrone 164.414 µM -0.891778789074306 0.185344358678245 no 2797 0.186255756441929 3922 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2119 5528445 120.635 µM -0.894654035001005 0.184578434240921 no 2798 0.185486028517826 3976 791935
SGTC_1057 3448-5381 134 µM -0.894930405183139 0.184504917006468 no 2799 0.185412146008898 3984 5497911
SGTC_3043 9092303 49.47 µM -0.896187682749392 0.184170698527201 no 2800 0.185076266512559 3979 25236084
SGTC_55 0767-0285 6.563 µM -0.896936048216382 0.183971941702386 no 2801 0.184876521558353 3880 3116166
SGTC_2794 7785382 27.27 µM -0.898062638578667 0.183672984900624 no 2802 0.184576078005411 3882 2205081
SGTC_183 3914-0051 30.55 µM -0.898715494625442 0.183499878858643 no 2803 0.184402110825225 4004 1596232
SGTC_1521 st012942 49.4 µM -0.898816754153557 0.183473038811365 no 2804 0.184375137241677 3983 24207259
SGTC_726 3448-4391 34.2 µM -0.900026675992004 0.1831525239119 no 2805 0.184053027343968 4082 1356692
SGTC_961 1252-1571 372 µM -0.902726857043644 0.182438491609593 no 2806 0.183335439422953 3965 6813498
SGTC_80 0159-0065 512.242 µM -0.904782628790416 0.181896033696953 no 2807 0.182790278120235 3869 1548079
SGTC_335 4077-0256 27.6 µM -0.90483208345623 0.181882996497822 no 2808 0.182777175926214 3959 3121989
SGTC_3190 9110366 49.47 µM -0.905632779472088 0.18167199899518 no 2809 0.182565126380465 3982 17123768
SGTC_1243 0416-0003 5.65 µM -0.906025338780218 0.181568608677884 no 2810 0.182461220452315 3980 2141977
SGTC_39 0986-0283 58.349 µM -0.907364809206926 0.181216102895868 no 2811 0.182106956208626 4076 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2998 9066762 71.4286 µM -0.907632992962806 0.181145577042229 no 2812 0.182036078445984 4005 4945196
SGTC_1942 st076330 65.2 µM -0.908224812360513 0.180990003672498 no 2813 0.181879728688157 3992 24208414
SGTC_2780 5215298 71.43 µM -0.9086164374806 0.180887102028674 no 2814 0.181776313431021 4015 2834131
SGTC_2821 7996764 71.43 µM -0.909086898437784 0.180763534330441 no 2815 0.181652128881465 4012 2987135
SGTC_2989 9073649 71.4286 µM -0.909279034911616 0.180713084447801 no 2816 0.181601427125023 3878 21367202
SGTC_2081 5214970 32.255 µM -0.914826746527487 0.179260213239683 no 2817 0.180141295574614 3903 2063512
SGTC_1640 st009078 66.4 µM -0.914889200157399 0.179243899397885 no 2818 0.180124900134226 3958 690618
SGTC_1100 amiodarone 5.07 µM -0.914914025163371 0.179237414986597 no 2819 0.180118383288745 4079 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1975 st070967 30.8 µM -0.915953129025568 0.178966128384956 no 2820 0.17984573951305 3953 261391
SGTC_2600 tangeritin 87.95 µM -0.916965972842556 0.178701946503219 no 2821 0.179580235562728 3928 68077 A bioactive flavone.
SGTC_98 0074-0023 107.663 µM -0.918710272076461 0.178247553671853 no 2822 0.179123567765367 4002 3563821
SGTC_2186 6124449 200 µM -0.919072544652798 0.17815327246679 no 2823 0.179028814371969 4003 3834182 YLR033W RSC58
SGTC_1007 4101-0031 70 µM -0.919493246867961 0.178043824441847 no 2824 0.178918818130093 3951 1146276
SGTC_1312 1218-2183 165 µM -0.920299898556574 0.177834088111118 no 2825 0.178708031039893 3997 6744073
SGTC_759 3486-0358 89.3 µM -0.921854125343403 0.177430415490602 no 2826 0.178302335296434 3960 875103
SGTC_318 1488-0629 67.2 µM -0.92230681458793 0.177312949329716 no 2827 0.178184280231851 4047 3662576
SGTC_1867 st057372 64 µM -0.923160387538554 0.177091593404781 no 2828 0.177961814333522 3973 688837
SGTC_954 1189-0853 2.85 µM -0.923750767471394 0.176938593146649 no 2829 0.17780804669127 3936 2828194
SGTC_2406 ethylparaben 405.7 µM -0.925241232093634 0.176552702694236 no 2830 0.177420220141159 4049 8434 A possible steroid mimic.
SGTC_1374 2889-5571 141 µM -0.926888131186382 0.176126929892839 no 2831 0.176992310089249 4049 2853281
SGTC_1530 rhein 70.4 µM -0.927020790845202 0.176092661702177 no 2832 0.176957869834633 4064 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_100 0086-0128 49.5915 µM -0.927507005717677 0.175967100421817 no 2833 0.176831678037694 4066 93297
SGTC_1675 st018485 24.5 µM -0.928057019373461 0.175825131948717 no 2834 0.176688996542433 4058 3323024
SGTC_945 3381-0768 11.3 µM -0.928057248417233 0.175825072843493 no 2835 0.176688937140334 4056 1126236 YIL048W NEO1
SGTC_2572 astragaloside iv 100 µM -0.928119553246098 0.175808995419466 no 2836 0.176672778961358 4080 45006101 An anti-inflammatory agent.
SGTC_3084 9116877 49.47 µM -0.928438009762954 0.175726833982429 no 2837 0.176590204812889 3899 27241325
SGTC_1146 3579-1023 7 µM -0.929042615016073 0.175570913425097 no 2838 0.176433500926319 4049 X1146
SGTC_3200 9114385 49.47 µM -0.929733892260773 0.175392748647932 no 2839 0.176254440886638 4074 17018030 YLR208W SEC13
SGTC_2436 5633522 8.09 µM -0.930471673064472 0.175202724872788 no 2840 0.176063462046537 3985 5724242
SGTC_1278 0874-0585 172 µM -0.932967697117471 0.174560814255197 no 2841 0.175418323552732 4060 766306
SGTC_284 0988-0104 32.6 µM -0.934041675041083 0.174285076022956 no 2842 0.175141197994941 3993 4666532
SGTC_2861 9024595 19.48 µM -0.934117055768737 0.174265732814107 no 2843 0.175121757447148 3900 16482810
SGTC_2318 6029776 164 µM -0.934898842991283 0.174065201326889 no 2844 0.174920216712215 4037 818325
SGTC_1594 piperine 70.1 µM -0.937260578570544 0.173460298263526 no 2845 0.174312267790414 3986 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_83 0170-0301 39.027 µM -0.937722214555263 0.173342217565858 no 2846 0.174193592266983 3947 3089716
SGTC_3080 9117754 49.47 µM -0.939878747929797 0.172791281500981 no 2847 0.173639879786221 4026 9550191
SGTC_2232 chlorophetanol 41.5365 µM -0.940684563275428 0.172585704175947 no 2848 0.173433265999842 4085 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_33 0986-0033 35.816 µM -0.945165436776835 0.171445402818631 no 2849 0.172287211009652 3937 2848082
SGTC_659 k018-0002 107 µM -0.94537308144892 0.171392678002082 no 2850 0.172234219972332 4042 6797879 YHR007C ERG11
SGTC_910 3454-3003 490 µM -0.94554172779911 0.171349863207597 no 2851 0.172191188983156 3968 820824
SGTC_217 ketoconazole 989 nM -0.947098806692511 0.170954885566009 no 2852 0.171794216378331 3898 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2716 st080858 38.6235 µM -0.947492299342206 0.170855162215571 no 2853 0.171693989197051 4005 5296050
SGTC_1173 0443-0020 122 µM -0.9480951823188 0.170702445025328 no 2854 0.171540500322346 4021 5331295
SGTC_1856 st057054 55.7 µM -0.948157842459988 0.170686577505147 no 2855 0.17152455261524 4068 1266018
SGTC_3009 9080819 71.4286 µM -0.949791471192755 0.170273224490045 no 2856 0.171109110188056 4048 17027216
SGTC_222 nsc-310342 10.666 µM -0.95328802379992 0.169390657736252 no 2857 0.170222078891064 3997 432556
SGTC_2334 9017922 200 µM -0.954280008661548 0.169140805871088 no 2858 0.169970962300632 4114 3163164
SGTC_1330 1469-0054 61.8 µM -0.955582195031286 0.168813182757735 no 2859 0.169641680240343 4034 7102664
SGTC_810 3825-7150 143 µM -0.956421222040956 0.168602304210055 no 2860 0.169429733561202 4103 22330411 YGL099W LSG1
SGTC_612 0302-0167 22.4 µM -0.956532709978022 0.168574295915093 no 2861 0.169401583380585 4060 235821
SGTC_1369 1866-0067 208 µM -0.958550301984606 0.168067948011177 no 2862 0.168892669612301 4051 3531355
SGTC_2876 9059903 25.97 µM -0.958651428978291 0.168042594312682 no 2863 0.168867187397568 3986 6916095
SGTC_148 3253-0744 288.01 µM -0.960520212379508 0.167574511915725 no 2864 0.168396731653934 3944 6893655
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.962763430625282 0.167013753442823 no 2865 0.167833128269401 4094 6708784 An antioxidant flavonoid
SGTC_2131 toluylene red 5.2905 µM -0.966046769776006 0.166195170594977 no 2866 0.167010389239706 4050 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_758 0868-0029 16 µM -0.967279556544839 0.165888489775011 no 2867 0.166702150325277 4086 762687
SGTC_2897 9048598 12.99 µM -0.969530016006464 0.165329586113302 no 2868 0.166140405770247 4037 6467404
SGTC_280 3448-3607 3.04 µM -0.971296290519755 0.16489178465755 no 2869 0.165700377740952 4030 626179
SGTC_1753 st043925 64 µM -0.972135683603846 0.164683990105746 no 2870 0.165491526006191 4109 670181
SGTC_594 1487-1584 10.8 µM -0.972532523951937 0.164585810047933 no 2871 0.165392846359068 4018 5013332
SGTC_2133 5320837 200 µM -0.973699555755326 0.164297301057035 no 2872 0.165102868974859 4108 2841355
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.974083031713162 0.164202571268496 no 2873 0.165007656947856 4091 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3058 9093861 49.47 µM -0.976071049964039 0.163712040498342 no 2874 0.164514628237383 4069 17217477
SGTC_181 1447-1644 8.07 µM -0.977768768367757 0.163293893190334 no 2875 0.164094350521946 4080 534600
SGTC_2105 5350118 200 µM -0.978893170717182 0.163017335684593 no 2876 0.16381638345288 4055 2133313
SGTC_1245 0418-0076 17.2 µM -0.978966266495875 0.162999367625344 no 2877 0.163798323798909 4129 6790114
SGTC_531 3788-1495 174 µM -0.9817821918973 0.162308150353506 no 2878 0.163103581582392 4025 2896655
SGTC_1306 1185-0270 9.02 µM -0.98254619921041 0.162120941195806 no 2879 0.162915417271792 4096 1548076
SGTC_2939 9044578 71.43 µM -0.986196588134746 0.161228406973209 no 2880 0.162018326613978 4015 2653634
SGTC_11 0438-0307 1.3 µM -0.988113347505714 0.160761037826873 no 2881 0.161548569769312 4051 4011476
SGTC_3267 9137951 49.47 µM -0.988396721971526 0.160692016922817 no 2882 0.16147919614906 4103 16643986
SGTC_701 4424-0219 185 µM -0.988414922677516 0.160687584477829 no 2883 0.161474741052141 4122 2911779
SGTC_1626 st003712 1.76 µM -0.997306978996626 0.158531637670993 no 2884 0.159307763603386 4123 24207035
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.999117366658588 0.158095030597005 no 2885 0.158868919613183 4102 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.00277944433172 0.157214271012222 no 2886 0.157983644421073 4071 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3345 9148410 3.559 µM -1.00287726164579 0.157190789475176 no 2887 0.157960042438617 4059 4903596
SGTC_1036 k216-0215 33.5 µM -1.0045657831031 0.156785814945571 no 2888 0.157552990183521 4076 622330
SGTC_233 rapamycin 362 pM -1.00543128523698 0.156578499553695 no 2889 0.15734461082025 4078 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3183 9108214 49.47 µM -1.00567257821587 0.156520734367272 no 2890 0.157286549134179 4024 4974831
SGTC_2088 5278280 127.392 µM -1.00612653368404 0.156412096127689 no 2891 0.157177353223559 4158 791502
SGTC_1886 st057356 49.9 µM -1.00921558863043 0.155674158662642 no 2892 0.156435626061305 4048 24207747
SGTC_3238 9133470 49.47 µM -1.00956412628969 0.155591041661396 no 2893 0.156352082030318 4109 3534688
SGTC_1022 4477-0945 21.3 µM -1.01033747047918 0.155406724102823 no 2894 0.156166817374689 4057 4648966
SGTC_154 3389-1638 511.116 µM -1.01357086379238 0.154637643673772 no 2895 0.155393783179028 4106 5238686
SGTC_1394 3474-0001 65.7 µM -1.01371618883285 0.154603136475951 no 2896 0.155359098510517 4094 5017666 YIL048W NEO1
SGTC_606 k015-0008 38.6 µM -1.01663028142212 0.153912264050741 no 2897 0.154664671618798 4201 1970475
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.01678509534252 0.153875618042783 no 2898 0.154627837001621 4149 688788
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.01688594271138 0.15385174956516 no 2899 0.154603845674265 3978 17037758
SGTC_2158 5657123 3.6195 µM -1.01840092677921 0.153493479217679 no 2900 0.154243730974321 4054 2858827
SGTC_3309 9129340 25.759 µM -1.01905185849338 0.153339713761276 no 2901 0.154089173739616 4125 17158987
SGTC_1181 1222-0449 220 µM -1.02083744781316 0.15291843945041 no 2902 0.153665729552743 4182 658318
SGTC_477 mead ethanolamide 10 µM -1.02170243262219 0.152714639649718 no 2903 0.15346087970357 4022 16061185
SGTC_2003 4023581 200 µM -1.02241613947318 0.152546618291101 no 2904 0.153291992479188 4154 16641307
SGTC_1752 st044819 83.042 µM -1.02324533411153 0.152351562812526 no 2905 0.153095931638145 4112 441209 YML126C ERG13
SGTC_2246 7293507 91.5585 µM -1.02344288604949 0.152305116141549 no 2906 0.153049245541226 4161 887656
SGTC_1117 retinoic acid 1.10837 µM -1.0251874494677 0.151895357818946 no 2907 0.152637374495402 4161 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1923 st058458 19.1 µM -1.02672702673015 0.151534354999982 no 2908 0.15227450962845 4142 3534982
SGTC_1654 st012436 41.8 µM -1.0272627210987 0.151408878302781 no 2909 0.152148385568863 4070 4323132
SGTC_2809 7964133 12.99 µM -1.02903544359062 0.150994142931077 no 2910 0.151731509916571 4138 1253665
SGTC_1909 st060837 51.5 µM -1.02974619281962 0.150828072892087 no 2911 0.151564582613697 4106 678937
SGTC_3049 9092223 49.47 µM -1.0316549793218 0.15038267755352 no 2912 0.151116887430071 4102 8623917
SGTC_2330 7979373 200 µM -1.03209244342307 0.150280723449686 no 2913 0.151014406735274 4069 1863007
SGTC_1704 st028805 70.8 µM -1.03601594976987 0.149368382046504 no 2914 0.150097350789761 4158 2876101
SGTC_1958 st076513 41.9 µM -1.03675238305793 0.149197550639052 no 2915 0.149925636146135 4086 732122 YGL099W LSG1
SGTC_49 0717-0965 32.132 µM -1.03813812603805 0.148876451875369 no 2916 0.149602876838663 4218 5889349 YGL099W LSG1
SGTC_1341 1486-1360 280 µM -1.0388749367468 0.148705909252738 no 2917 0.149431452056973 4114 3976547
SGTC_3207 9114163 49.47 µM -1.0392855493027 0.148610925325152 no 2918 0.149335976747439 4180 849233
SGTC_647 0140-0236 81 µM -1.03941194433333 0.148581695475426 no 2919 0.149306595673472 4146 990837
SGTC_2929 9013348 24.6 µM -1.04089431756537 0.148239171853109 no 2920 0.148962299648852 4124 2995952
SGTC_1841 st054148 70 µM -1.04331621767372 0.147680694498306 no 2921 0.148400931193431 4166 675442
SGTC_953 1188-0045 9.7 µM -1.04671785153692 0.146898678114647 no 2922 0.147614863939906 4158 6144426
SGTC_1859 st055998 20 µM -1.04823980909539 0.146549689680142 no 2923 0.147264066774931 4079 676301
SGTC_1232 0279-0259 161 µM -1.05323857083763 0.145407379815448 no 2924 0.146115832461698 4145 1560000
SGTC_1674 st016616 23.6 µM -1.05735137368083 0.144472030624257 no 2925 0.145175627552796 4097 625830
SGTC_213 1246-0773 967 nM -1.05783485437177 0.144362342525804 no 2926 0.145065369754065 4159 6251622
SGTC_2683 piperine 63.03 µM -1.05969983351974 0.143939757418717 no 2927 0.144640589285323 4133 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_798 1287-0182 476 µM -1.06100181203526 0.143645237523123 no 2928 0.144344538839942 4187 1649755
SGTC_2077 5212015 200 µM -1.06136481602848 0.143563195129776 no 2929 0.144262070019381 4008 780900
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.0614230430489 0.143550038207355 no 2930 0.144248844709019 4193 5377381
SGTC_1008 4106-0037 6 µM -1.06781504163622 0.142110655911381 no 2931 0.142801975828678 4117 2905394
SGTC_228 caffeine 993.056 µM -1.06860149857385 0.141934234855738 no 2932 0.142624636504089 4170 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1651 st011928 86.1 µM -1.07122808382894 0.141346104070054 no 2933 0.142033443475482 4186 720198
SGTC_1618 st003135 44.5 µM -1.0721681892408 0.14113600272916 no 2934 0.141822247808891 4128 1270615
SGTC_2385 9074692 200 µM -1.07433642781467 0.140652237354854 no 2935 0.14133596195026 4180 17046906
SGTC_2676 harmalol 100 µM -1.07694228237702 0.14007232415135 no 2936 0.140753025924524 4120 5459187 A monoamine oxidase inhibitor
SGTC_1123 mangostin 811.285 nM -1.0778556274712 0.139869451134559 no 2937 0.140549095066362 4183 5281650 An antioxidant.
SGTC_1286 0929-0070 131 µM -1.07895763765273 0.139624937635308 no 2938 0.140303306354678 4240 1420408
SGTC_112 phenothiazine 287.218 µM -1.07976443766342 0.139446109631214 no 2939 0.14012354553894 4124 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_760 0568-0725 82.9 µM -1.08033513093852 0.139319709031644 no 2940 0.13999648551622 4203 3916171
SGTC_2165 5727197 32.143 µM -1.08273075924679 0.138789961387591 no 2941 0.139463973443654 4330 1361712
SGTC_1788 fluconazole 20 µM -1.08365206004226 0.138586598947751 no 2942 0.139259549449943 4216 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_443 clozapine 122 µM -1.08802314538827 0.137624518953916 no 2943 0.138292444926752 4126 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1487 3970-0795 2.82 µM -1.08907864891323 0.137392886565274 no 2944 0.138059602218334 4214 3765103
SGTC_645 0845-0943 5.41 µM -1.08975800812201 0.137243940696332 no 2945 0.137909877958146 4190 1885106
SGTC_2491 paeonol 100 µM -1.09495665346894 0.136107816833304 no 2946 0.136767813564045 4110 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1141 3253-0389 52.6 µM -1.09613929538922 0.135850260926243 no 2947 0.136508910187997 4187 5402031
SGTC_48 0382-0018 55 µM -1.09653967161445 0.135763142609214 no 2948 0.136421336025591 4254 762596
SGTC_2313 7726885 200 µM -1.09890666494149 0.135248887678204 no 2949 0.135904389608105 4220 726423
SGTC_1459 k035-0031 35.7 µM -1.10061447132365 0.134878678614813 no 2950 0.135532242269575 3949 3877128 YMR208W ERG12
SGTC_580 1123-0028 41 µM -1.1009857960636 0.134798276933714 no 2951 0.135451419559573 4230 1677248 YPR107C YTH1
SGTC_2868 9035608 32.47 µM -1.10576141770865 0.133767158614725 no 2952 0.134414899331829 4171 6462614
SGTC_1803 st050068 52.4 µM -1.10693418727993 0.133514773971692 no 2953 0.134161191804839 4254 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1168 k815-0004 80.5 µM -1.10762941057534 0.133365313883084 no 2954 0.134010948191961 4173 642433
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.10923624541897 0.13302031480881 no 2955 0.133664140157638 4181 676296 Flavone; oxidizing agent.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.11022877797782 0.132807518085376 no 2956 0.133450227418796 4266 165506
SGTC_2324 6149169 200 µM -1.11161891656774 0.132509869819351 no 2957 0.133151017823759 4102 2888231
SGTC_2602 kawain 100 µM -1.11207714888551 0.132411856624862 no 2958 0.133052490417612 4202 5369129
SGTC_230 MPP+ 141.667 µM -1.11255557730016 0.132309576928695 no 2959 0.132949674084861 4170 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3107 9121808 49.47 µM -1.11388362919537 0.132025947903138 no 2960 0.132664556706654 4122 662681
SGTC_1499 4480-0877 67.3 µM -1.11578152295913 0.13162134727141 no 2961 0.132257832361324 4156 2861909
SGTC_81 0411-0046 9.971 µM -1.1174615539721 0.131263906204618 no 2962 0.131898514574115 4152 12925265
SGTC_2739 tacrine 100.86 µM -1.12355432467795 0.129973243453031 no 2963 0.130601071087949 4266 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1571 st070080 73.4 µM -1.12902353243729 0.128822178513244 no 2964 0.129443953357036 4248 4315245
SGTC_1490 4089-0339 670 nM -1.13272796390196 0.128046561842392 no 2965 0.128664255312394 4194 742542
SGTC_3298 9116858 71.43 µM -1.13421957900032 0.12773517234622 no 2966 0.128351226615901 4281 2506942
SGTC_407 eburnamonine 100 µM -1.14018985772625 0.126494088554223 no 2967 0.12710360599928 4065 3195
SGTC_1152 3909-8331 15.9 µM -1.14061919823181 0.126405163412561 no 2968 0.12701421226899 4190 16001939
SGTC_618 k072-0232 33.2 µM -1.14110658966914 0.126304267543089 no 2969 0.126912784696589 4271 5872756 YGL099W LSG1
SGTC_360 0957-0399 1.01 µM -1.14174926177195 0.126171312525425 no 2970 0.1267791289736 4241 6752301 YPR165W RHO1
SGTC_815 1582-0027 36.9 µM -1.14293299629624 0.125926678738973 no 2971 0.126533205740168 4267 3128206
SGTC_2083 5306046 65.942 µM -1.14468623763784 0.12556495720856 no 2972 0.126169577206279 4236 539837
SGTC_1414 3917-0015 5.4 µM -1.14549509029582 0.125398322704178 no 2973 0.12600206404335 4230 6618702
SGTC_2544 sphondin 68.51 µM -1.14643582592354 0.12520471277524 no 2974 0.125807433090753 4225 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_115 0527-0192 112.043 µM -1.14886950630664 0.124704813216665 no 2975 0.125304896640299 4227 4233931
SGTC_2744 captopril 92.04 µM -1.1498907937527 0.124495447784746 no 2976 0.125094426576453 4292 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2055 5235184 200 µM -1.15180995060248 0.124102682897966 no 2977 0.124699589010516 4281 2836034
SGTC_1736 st036774 51 µM -1.15214823818002 0.124033540658061 no 2978 0.124630081840964 4299 1272247
SGTC_2020 4017018 200 µM -1.15231566918997 0.123999329585155 no 2979 0.124595690197402 4300 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_593 1203-0218 61.7 µM -1.15311500567245 0.12383609268145 no 2980 0.124431591651404 4266 3666956
SGTC_2445 5742597 35.57 µM -1.15758943837123 0.12292512193525 no 2981 0.12351581068256 4239 1774255
SGTC_1266 0828-0227 32.9 µM -1.15793094613169 0.122855786268774 no 2982 0.123446108785112 4237 3913820
SGTC_1061 3448-9325 110 µM -1.16004370783868 0.12242744594888 no 2983 0.123015505611504 4200 723482
SGTC_2017 5132927 60.65 µM -1.16264171274002 0.121902165831817 no 2984 0.122487449682992 4241 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2906 7926292 26.41 µM -1.1628379225971 0.121862559347547 no 2985 0.122447633863366 4250 2966319
SGTC_2518 prenyletin 46.28 µM -1.16316312086967 0.121796935458527 no 2986 0.122381663115651 4244 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1281 0884-0031 11.8 µM -1.16626506324767 0.12117222195398 no 2987 0.121753646942581 4274 1548255
SGTC_1087 pterostilbene 9.05 µM -1.16626735196783 0.121171761852394 no 2988 0.121753184408107 4268 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2199 6590217 200 µM -1.16821232084572 0.120781208751733 no 2989 0.121360565924428 4150 703109
SGTC_2757 clomiphene 4.22 µM -1.1723753942948 0.119948236452721 no 2990 0.120523186931254 4279 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1428 4049-0204 61.7 µM -1.17318538902578 0.119786639653417 no 2991 0.120360734976304 4308 X1428
SGTC_2242 6630449 61.2675 µM -1.17363024306548 0.119697955040903 no 2992 0.120271581017787 4309 691249 YDR170C SEC7
SGTC_1482 3346-2049 8.48 µM -1.17693414062415 0.119040749944338 no 2993 0.119610897023142 4274 3826804
SGTC_1500 4488-1866 171 µM -1.1774373847574 0.118940869588036 no 2994 0.119510487835079 4328 2900003
SGTC_1275 0867-0008 21.1 µM -1.17803276447368 0.118822779253298 no 2995 0.119391772213307 4236 3422836
SGTC_104 0074-0074 590.992 µM -1.18197690523829 0.118042571657093 no 2996 0.118607432352838 4048 3943124
SGTC_2080 5212524 12.4 µM -1.18337598374392 0.117766686461737 no 2997 0.118330085527017 4217 260183
SGTC_1682 st012968 530 nM -1.18539623231991 0.11736911799406 no 2998 0.117930410354264 4287 24207270
SGTC_714 4296-0578 26.1 µM -1.19055836863836 0.116357571492738 no 2999 0.116913501593194 4328 1589775
SGTC_2872 9044037 25.97 µM -1.19366714932898 0.115751382557839 no 3000 0.116304097801393 4309 6465195
SGTC_26 0302-0163 425.158 µM -1.19666535762666 0.115168882348951 no 3001 0.115718507385821 4347 3100915
SGTC_1895 st058434 18.3 µM -1.19675015092448 0.115152438830871 no 3002 0.115701976619884 4293 5393175
SGTC_3048 9093155 49.47 µM -1.19693810368337 0.115115996092193 no 3003 0.115665340516568 4261 25236002
SGTC_2621 lithochol-11-enic acid 100 µM -1.19787176074489 0.114935087997599 no 3004 0.11548347247174 4246 6708711
SGTC_1525 8-methoxypsoralen 92.5 µM -1.19866734534701 0.114781092865508 no 3005 0.115328660126064 4333 4114 Related to psoralen; DNA damaging agent.
SGTC_1779 st039427 55 µM -1.19911399295474 0.114694703123755 no 3006 0.115241811907031 4266 1124498
SGTC_2362 9071156 126 µM -1.19947555557611 0.114624804253688 no 3007 0.115171542063082 4294 653133
SGTC_1502 4534-4282 27.7 µM -1.19984100827169 0.11455418414935 no 3008 0.115100547143486 4233 3278949
SGTC_2704 st078022 71.1 µM -1.20062180611115 0.114403406492763 no 3009 0.114948969190982 4319 54697681
SGTC_3035 9091303 49.47 µM -1.20069133792895 0.114389986254997 no 3010 0.114935477718433 4364 25237002
SGTC_2778 tioconazole 65.09 nM -1.20070882903003 0.114386610498769 no 3011 0.114932084043574 4165 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.20220080654939 0.114098922086424 no 3012 0.114642868457806 4291 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3349 9149703 23.001 µM -1.20264082487846 0.114014174687362 no 3013 0.114557671140665 4297 4910494
SGTC_97 0535-0701 19.132 µM -1.20337694545944 0.113872498364962 no 3014 0.114415242625461 4190 2832013 YGL099W LSG1
SGTC_859 0439-0102 54.6 µM -1.20757273278233 0.113067357822508 no 3015 0.113605826392425 4309 610143
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.20776729122691 0.113030122303973 no 3016 0.113568393093914 4284 688751
SGTC_2156 5649887 115 µM -1.20990940452982 0.112620733014017 no 3017 0.113156829057608 4320 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_87 0100-0052 35.5 µM -1.22196020802825 0.110337378803756 no 3018 0.110861337576398 4345 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1861 st057647 17.4 µM -1.22294876946716 0.110151552877199 no 3019 0.110674523329187 4376 688668
SGTC_852 0418-0143 439 µM -1.22730663993616 0.109335053525418 no 3020 0.109853680453714 4303 5369229
SGTC_2457 5731572 11.68 µM -1.22754096241442 0.109291273897851 no 3021 0.109809667889082 4351 2865357
SGTC_2651 TUB2.036 5 µM -1.22952497602499 0.108921095502115 no 3022 0.109437519723301 4236 15992207 YFL037W TUB2
SGTC_1143 3454-2408 5.08 µM -1.23081317026897 0.108681226600924 no 3023 0.109196374284044 4316 X1143
SGTC_1010 4112-3296 15.2 µM -1.23775773512496 0.107394653463826 no 3024 0.107902952117849 4351 704384
SGTC_459 nigericin 15.3 µM -1.25420414579095 0.104391607622601 no 3025 0.104883906690196 4405 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2424 5537928 59.2 µM -1.25445399575093 0.104346460124675 no 3026 0.104838518527521 4329 5382802
SGTC_2306 7482397 179.52 µM -1.25672423290125 0.103936880108429 no 3027 0.10442675502764 4356 891448
SGTC_3326 9140064 16.379 µM -1.25969534524927 0.10340261629008 no 3028 0.10388964260044 4276 1868434
SGTC_198 3454-2873 16.191 µM -1.26224194000446 0.102946277941043 no 3029 0.103430870752583 4334 710957
SGTC_780 0109-0199 192 µM -1.26283061008955 0.10284099941121 no 3030 0.103325030759759 4383 610414
SGTC_1478 0453-0656 35.7 µM -1.26446440565332 0.102549219172684 no 3031 0.103031694330009 4337 5258496
SGTC_3164 9100705 49.47 µM -1.26581917331602 0.102307727446879 no 3032 0.102788914522419 4339 17174235
SGTC_1980 st071811 45.7 µM -1.26632076107398 0.10221842279846 no 3033 0.102699133513116 4412 4974850
SGTC_1116 jasmonic acid 1.58368 µM -1.26721150463287 0.102059971113644 no 3034 0.102539836599436 4378 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_269 exalamide 29 µM -1.2681435600181 0.101894362012752 no 3035 0.102373344049229 4276 3316 A derivative of salicylamide.
SGTC_1072 oxiconazole 14.9 nM -1.27014165943161 0.101539995739538 no 3036 0.102017087255698 4319 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1750 st081859 2.357 µM -1.27102976323349 0.101382777489607 no 3037 0.101859030198043 4276 5291695
SGTC_997 3996-0078 137 µM -1.27354646536757 0.100938216968686 no 3038 0.101412097618859 4387 735687
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.27957687841487 0.0998787663368356 no 3039 0.100346992947977 4395 1273210
SGTC_478 N-arachidonylglycine 10 µM -1.28250348196661 0.0993675443184532 no 3040 0.0998330421401755 4348 5283389
SGTC_2925 9010536 32.5 µM -1.28513848342635 0.0989088984676915 no 3041 0.0993719478705729 4273 2994177
SGTC_2941 9056145 11.23 µM -1.28514406898025 0.0989079278993044 no 3042 0.0993709721206761 4276 2119517
SGTC_2670 beta-carotene 100 µM -1.2863296615503 0.0987020722282788 no 3043 0.0991640174370977 4309 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3312 9133330 71.43 µM -1.28680860635685 0.0986190015281622 no 3044 0.09908050322942 4380 17617324
SGTC_135 0933-0004 26.348 µM -1.28845514295973 0.0983338079897382 no 3045 0.0987937870079897 4306 21230617 YGL099W LSG1
SGTC_2702 st077768 96.8 µM -1.29271578009969 0.0975986355499216 no 3046 0.0980546889923593 4329 6484119
SGTC_2093 5331342 194.4 µM -1.29289115561466 0.0975684611256425 no 3047 0.098024353434863 4411 33839
SGTC_1205 4161-2785 76 µM -1.29549471572596 0.0971213071690032 no 3048 0.0975748115452975 4383 3498106
SGTC_1837 st055472 66.5 µM -1.29589628862664 0.0970524722738583 no 3049 0.0975056090347257 4422 676091
SGTC_1174 0739-0097 51.1 µM -1.29828864111625 0.0966431334972809 no 3050 0.09709408407884 4405 728447
SGTC_306 1672-3436 11.6 µM -1.29831975818262 0.0966378176401533 no 3051 0.0970887398300183 4381 6797378
SGTC_548 1436-0017 110 µM -1.30132362644189 0.0961256649955499 no 3052 0.0965738516932276 4403 9677137
SGTC_1494 4358-1428 177 µM -1.30209830818516 0.0959939077954474 no 3053 0.0964413907208274 4390 1564571
SGTC_133 0724-0033 378.92 µM -1.30574314868201 0.0953757785337628 no 3054 0.0958199595826544 4197 280309
SGTC_1749 st037932 54.2 µM -1.30734448114543 0.0951051365943877 no 3055 0.0955478718601559 4393 594497
SGTC_1295 1013-0063 9.78 µM -1.31344207766858 0.0940797561265494 no 3056 0.0945170133239485 4396 6826038
SGTC_3150 9097574 49.47 µM -1.31579895374701 0.0936856139301018 no 3057 0.0941207652712842 4412 17217476
SGTC_2182 6325192 200 µM -1.32024084752819 0.0929461089613911 no 3058 0.0933773090104962 4393 736248
SGTC_2563 tomatine 8.54 µM -1.32057931108923 0.0928899375790884 no 3059 0.093320837486005 4345 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2827 7993847 71.43 µM -1.32149749418915 0.0927376823968153 no 3060 0.0931677687480281 4432 2985692
SGTC_3176 9106582 49.47 µM -1.32179596967948 0.0926882282919261 no 3061 0.0931180503897095 4366 17018027
SGTC_504 lovastatin 124 µM -1.32242041435467 0.092584827774228 no 3062 0.0930140973580657 4401 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_68 0986-0284 82.829 µM -1.32617811728066 0.0919643986115411 no 3063 0.0923903528992855 4393 423278 YIL048W NEO1
SGTC_686 1319-0111 510 µM -1.32642586949417 0.0919236010356565 no 3064 0.0923493373154713 4411 4562600
SGTC_3007 9078383 71.4286 µM -1.32734116366229 0.0917729949653082 no 3065 0.092197926455481 4383 6496995
SGTC_382 3229-0966 23.2 µM -1.32875918919484 0.0915400285932844 no 3066 0.0919637151768358 4424 5722370
SGTC_3186 9110464 49.47 µM -1.32948475886813 0.0914209949169615 no 3067 0.0918440454137016 4374 17018021
SGTC_1728 st035614 33.7865 µM -1.33221820080437 0.0909735890437967 no 3068 0.0913942486912818 4325 15945546
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.33364389699209 0.0907408786242146 no 3069 0.0911602947021917 4409 6728940
SGTC_672 1441-0018 53.7 µM -1.33416860927948 0.0906553433392498 no 3070 0.0910743023281814 4395 251141
SGTC_3304 9125678 46.087 µM -1.33469505410041 0.0905695857833742 no 3071 0.0909880864948943 4334 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2926 9010726 65.15 µM -1.33615628418595 0.090331867828338 no 3072 0.0907490982032243 4386 2994293
SGTC_2814 7977482 42.97 µM -1.33626677291613 0.0903139120009144 no 3073 0.0907310464218841 4393 6456762
SGTC_1562 morin hydrate 59.1 µM -1.3397661708384 0.0897465858384574 no 3074 0.0901606885318803 4404 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1261 0712-0010 12.7 µM -1.34051217347867 0.089625986418486 no 3075 0.090039444643393 4379 2840123
SGTC_841 0251-0215 91.2 µM -1.34051945570415 0.0896248097619065 no 3076 0.0900382616989096 4427 3888614
SGTC_3033 9090887 49.47 µM -1.34140695924846 0.0894814935865588 no 3077 0.0898941796608621 4413 19325384
SGTC_2415 st077333 57.7 µM -1.34632610953022 0.0886902268276277 no 3078 0.0890986845228409 4415 2766255
SGTC_1228 0124-0032 52.5 µM -1.35081169210413 0.087973254428076 no 3079 0.0883778808708358 4443 X1228
SGTC_3032 9089427 49.47 µM -1.35131624023573 0.0878928790021815 no 3080 0.0882970759556635 4387 17173707
SGTC_46 0329-0187a 2.197 µM -1.35574358607873 0.0871899422548131 no 3081 0.0875903831380139 4426 46494817
SGTC_2856 9022925 19.48 µM -1.3570625836537 0.0869813366953033 no 3082 0.0873806629555927 4427 4944862
SGTC_1587 estradiol valerate 56.1 µM -1.35887816343723 0.0866948044483924 no 3083 0.0870925997411443 4450 13791 A steroid.
SGTC_2315 7733312 200 µM -1.35977249607531 0.0865539217178826 no 3084 0.0869509642769362 4306 726316
SGTC_3213 9129884 49.47 µM -1.36498204158296 0.0857366709890608 no 3085 0.0861293472193197 4393 17190742
SGTC_2541 muurolladie-3-one 83.07 µM -1.36515255887107 0.085710018952384 no 3086 0.0861025527957835 4367 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1175 0741-0056 27.6 µM -1.3659932464477 0.0855787092396397 no 3087 0.0859705415760911 4482 765927
SGTC_2889 9059656 51.95 µM -1.37067521769477 0.0848501713510347 no 3088 0.0852381117870934 4478 3949838
SGTC_1246 0422-0085 105 µM -1.37598605962946 0.0840294181736489 no 3089 0.0844129746125927 4429 264295
SGTC_998 3996-0085 177 µM -1.37806328637151 0.083710024174293 no 3090 0.0840918747610139 4442 715391
SGTC_539 4859-0462 2.54 µM -1.37971168853731 0.0834572158659931 no 3091 0.0838377163010422 4452 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2513 baicalein 25.65 µM -1.38447576709268 0.0827297956423711 no 3092 0.0831064115923749 4412 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_812 4251-0442 148 µM -1.3878356846359 0.0822196508422373 no 3093 0.0825935429452034 4451 5723007
SGTC_2693 st077581 40.7 µM -1.39051504572808 0.0818145375696328 no 3094 0.0821862668614426 4413 25238761
SGTC_1630 st005209 31.3 µM -1.39072366819086 0.081783057573604 no 3095 0.0821546188096876 4423 3367314
SGTC_2369 9071472 200 µM -1.39193187826197 0.081600924762588 no 3096 0.081971513710453 4449 17296037
SGTC_2278 7948257 134.34 µM -1.39462775964835 0.0811956342362196 no 3097 0.081564059768757 4434 1247028
SGTC_398 bronopol 33.3 µM -1.40498944195939 0.0796520208099781 no 3098 0.0800122089295559 4366 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2895 9054447 58.44 µM -1.40659785839073 0.0794144137538821 no 3099 0.0797733342479875 4500 2697450
SGTC_1458 k015-0034 6.33 µM -1.40734937360629 0.0793035784786811 no 3100 0.0796619077048674 4469 3598957
SGTC_348 k064-0012 10.7 µM -1.41093979358723 0.078775670314238 no 3101 0.0791311836431058 4388 5066323
SGTC_470 aa-861 153 µM -1.41926367009605 0.0775620379857296 no 3102 0.0779110797930475 4406 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_622 1348-1566 26.3 µM -1.42119943078097 0.0772818469022527 no 3103 0.0776293950694175 4443 7340407
SGTC_1924 st058459 75.1 µM -1.42344924145722 0.0769571656928205 no 3104 0.0773029832702784 4414 688683
SGTC_1706 st031321 9.9705 µM -1.4272858236376 0.076405882837088 no 3105 0.0767487625662375 4477 6103185
SGTC_2585 alliin 100 µM -1.42878491696699 0.0761912946561338 no 3106 0.0765330310159585 4499 87310 A garlic compound which reacts with lipids.
SGTC_3178 9107506 49.47 µM -1.42983022172587 0.0760419358372818 no 3107 0.0763828764493582 4443 8897194
SGTC_646 4092-0839 27.3 µM -1.43230310704313 0.0756894840876037 no 3108 0.0760285471420455 4478 877796
SGTC_1404 3909-7820 48.3 µM -1.44399784206369 0.074039513366538 no 3109 0.0743697911766466 4462 23741373
SGTC_333 3486-0131 40.1 µM -1.44464900881853 0.0739484564987349 no 3110 0.0742782496997864 4483 6744690
SGTC_942 3253-1115 227 µM -1.44746806635026 0.0735552362608335 no 3111 0.0738829370064256 4494 46497897
SGTC_2032 5185112 25.99 µM -1.44876990990364 0.0733741872930686 no 3112 0.0737009247734026 4344 5718189
SGTC_2307 7538926 6.34 µM -1.44948267972297 0.073275206029338 no 3113 0.0736014169254283 4434 96582
SGTC_155 k072-0202 43.6 µM -1.4544233303792 0.0725919112070977 no 3114 0.0729144877854606 4442 5857737
SGTC_3300 9124615 50.48 µM -1.45508621713262 0.0725006061256268 no 3115 0.0728226971825448 4491 24824903
SGTC_2142 5622915 118.518 µM -1.45723678308418 0.0722049958373995 no 3116 0.0725255151529646 4476 5322196
SGTC_896 0964-0007 44.5 µM -1.46321745799633 0.0713877669148017 no 3117 0.0717039426136578 4426 6756758
SGTC_2249 haloperidol 116.36 µM -1.46846855333434 0.0706761009846958 no 3118 0.0709884960605434 4426 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_916 4466-0038 42 nM -1.46940867986277 0.070549265749422 no 3119 0.0708609872262614 4531 5722064 YGL116W CDC20
SGTC_547 1120-0019 610 nM -1.47015344488873 0.0704489115691082 no 3120 0.0707601001257214 4462 3676939
SGTC_2381 9035592 200 µM -1.47135351928324 0.070287437169824 no 3121 0.0705977683136186 4492 4749657
SGTC_1892 st058411 7.36 µM -1.47499818532696 0.0697987786223196 no 3122 0.0701065156484417 4480 3934738
SGTC_3016 9080866 49.47 µM -1.4798343341389 0.0691544139565754 no 3123 0.0694587317179776 4453 17066299
SGTC_3310 9130229 44.1445 µM -1.48298221372723 0.0687374620616944 no 3124 0.0690395682083531 4496 7761258
SGTC_1782 st039423 80.636 µM -1.4830227805469 0.0687321014697952 no 3125 0.0690341791872952 4494 2068169
SGTC_951 1171-0579 82.7 µM -1.48309480321458 0.0687225850247644 no 3126 0.0690246122734113 4430 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2878 9043973 25.97 µM -1.48786275176621 0.0680948472855537 no 3127 0.0683935462885823 4507 6465167
SGTC_2980 9014342 25.29 µM -1.48942573715185 0.0678900342448022 no 3128 0.0681876477065203 4518 2996599
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.49760114764842 0.0668264747304754 no 3129 0.0671184542111016 4508 140250 A respiratory chain inhibitor.
SGTC_1773 st048542 73.5835 µM -1.49870023490656 0.066684480189065 no 3130 0.0669757078821527 4482 3237138
SGTC_1329 1447-1697 50.6 µM -1.50076624683168 0.0664181977166153 no 3131 0.0667080158425487 4499 2840515
SGTC_1225 1216-0074 20.6 µM -1.50238687494998 0.0662098962885766 no 3132 0.0664986120100782 4493 4241466
SGTC_2294 7971431 200 µM -1.50269025797364 0.0661709583633277 no 3133 0.0664594680352288 4485 5741572
SGTC_1038 k292-0204 154 µM -1.50537267339825 0.0658274530377419 no 3134 0.0661141452925603 4446 4454212
SGTC_146 3448-8650 53.125 µM -1.50712481875023 0.0656038237348061 no 3135 0.0658893331305366 4474 2891488 YIL048W NEO1
SGTC_2076 5212012 200 µM -1.50959923428353 0.0652890137537588 no 3136 0.0655728584343474 4482 604802
SGTC_2322 7413319 38.22 µM -1.51491271497332 0.0646169623653849 no 3137 0.0648972549712199 4446 1840400
SGTC_644 1498-1197 63.3 µM -1.51567594921694 0.0645208710861545 no 3138 0.0648006560059754 4550 6741615
SGTC_725 1497-0963 19 µM -1.51719393982857 0.0643300858828724 no 3139 0.0646088629620753 4571 3549977
SGTC_161 4065-0411 162.148 µM -1.52662265914457 0.0631548612705836 no 3140 0.0634274345984376 4489 1906281 YLR208W SEC13
SGTC_2969 9091408 28.7 µM -1.52859058659853 0.0629116948511747 no 3141 0.0631829855493585 4446 4286311
SGTC_1235 benzylparaben 21.5 µM -1.5290486089319 0.0628552042209625 no 3142 0.0631261969981051 4535 7180
SGTC_2348 9022543 33.42 µM -1.53193304125213 0.0625003576477891 no 3143 0.0627694794668993 4513 3162678 YDL140C RPO21
SGTC_1881 5652484 16 µM -1.53277210558989 0.0623974286578663 no 3144 0.0626660079175826 4501 2255129
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.54484424532687 0.0609311138897364 no 3145 0.0611919711028515 4520 75037 A free radical scavenger.
SGTC_1467 k284-1082 293 µM -1.55058192008668 0.060243711873938 no 3146 0.060500953843487 4494 3334705
SGTC_511 blebbistatin 171 µM -1.55092129431118 0.0602032440757805 no 3147 0.0604602733132457 4567 3476986 A myosin inhibitor.
SGTC_232 clozapine 119 µM -1.55131287327578 0.0601565777043767 no 3148 0.0604133616388911 4561 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_913 3487-1245 167 µM -1.55260336924116 0.0600029834551172 no 3149 0.0602589601235046 4457 4016153
SGTC_1452 4194-0072 190 µM -1.55904451763077 0.0592409479932855 no 3150 0.0594929219712524 4574 1343545
SGTC_2907 7721985 69.9 µM -1.56405125090295 0.0586538733627801 no 3151 0.0589027665006431 4525 3267881
SGTC_1402 3909-7673 35.9 µM -1.56580156161077 0.0584497179022751 no 3152 0.0586975402726734 4552 5328014
SGTC_3126 9127922 49.47 µM -1.58184721076463 0.0566040704169495 no 3153 0.05684222722044 4509 45595682
SGTC_1130 3454-2858 15.9 µM -1.58664227595092 0.0560615226759295 no 3154 0.056296843406977 4494 715628 YIL048W NEO1
SGTC_2196 6573537 42.6665 µM -1.59738347211667 0.0548610726394807 no 3155 0.0550901271833822 4576 2903087
SGTC_882 0843-0131 351 µM -1.60134494623465 0.0544234959526864 no 3156 0.0546502695844556 4560 5425421
SGTC_1850 st056238 17 µM -1.60210238054592 0.0543401464805662 no 3157 0.0545664858429595 4549 5393177
SGTC_3003 9075612 71.4286 µM -1.60308472566568 0.0542321978626516 no 3158 0.0544579748837926 4559 6501993
SGTC_3096 9117468 49.47 µM -1.60359787065849 0.0541758765396056 no 3159 0.0544013602065331 4513 41316311
SGTC_283 0987-0079 11.7 µM -1.60381292742337 0.0541522862944116 no 3160 0.0543776470983691 4541 411556
SGTC_3099 9120367 49.47 µM -1.61841978947909 0.0525689534137298 no 3161 0.0527860800208651 4583 24824940
SGTC_1531 st059297 52.4 µM -1.63633684550426 0.0506772325724032 no 3162 0.0508845543851945 4586 7566702
SGTC_1355 1499-0035 1.68 µM -1.64238501635427 0.0500510343560937 no 3163 0.0502551190813084 4563 1548538
SGTC_609 0986-0026 86.3 µM -1.65018136334596 0.049252958114523 no 3164 0.0494529236996863 4562 2848610
SGTC_505 gw-5074 63.9 µM -1.65245153708503 0.049022490954482 no 3165 0.0492212684038853 4573 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2977 9011197 71.43 µM -1.65951442094356 0.0483109752233161 no 3166 0.0485060885890416 4592 2704722
SGTC_3269 9137823 49.47 µM -1.66554974480005 0.0477095428912818 no 3167 0.0479015639214014 4520 17682936
SGTC_2174 5790901 200 µM -1.6721217957202 0.0470614597919721 no 3168 0.0472501537598198 4551 786020
SGTC_1560 lithocholic acid 53.1 µM -1.68032512958461 0.0462624375551353 no 3169 0.0464470371571411 4535 9903 A bile acid which acts as a detergent.
SGTC_1222 0366-0074 1.18 µM -1.68210045158896 0.046090959391889 no 3170 0.0462746814201285 4589 286520
SGTC_1647 st011722 22.4 µM -1.68951311480923 0.0453804800321745 no 3171 0.045560570363745 4586 2854783
SGTC_1416 3966-0321 25.3 µM -1.69029300454328 0.0453062451050302 no 3172 0.0454859563843228 4635 582530 YLR208W SEC13
SGTC_2116 5511452 16.8835 µM -1.6910461462836 0.04523464897284 no 3173 0.0454139947479871 4587 870744
SGTC_1870 st057514 26.5 µM -1.69559338608544 0.0448043052115527 no 3174 0.04498145559421 4587 5393161
SGTC_2413 inermin 26.06 µM -1.69779611121313 0.0445970311349892 no 3175 0.0447731250696683 4613 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_981 1488-1094 54.9 µM -1.70167340944006 0.0442340584307591 no 3176 0.0444083038665183 4565 3449522
SGTC_2349 9023730 187.07 µM -1.70544705516955 0.0438830794712217 no 3177 0.044055539360329 4608 4126287
SGTC_3041 9091929 49.47 µM -1.7073114123683 0.0437105103572031 no 3178 0.0438820930144233 4566 25236887
SGTC_2184 6075246 200 µM -1.71034631660447 0.0434307642940696 no 3179 0.0436009258708535 4577 2267320
SGTC_116 0155-0182 31.788 µM -1.71272511990103 0.0432125070695843 no 3180 0.043381560765828 4453 771486
SGTC_3121 9125696 49.47 µM -1.71395865046526 0.0430996788496928 no 3181 0.0432681601189275 4682 1235365
SGTC_1516 st013856 110 µM -1.71525860990326 0.0429810321968035 no 3182 0.0431489117362215 4605 5281404 A mutagen and neurotoxin.
SGTC_514 4466-0038 2.65 nM -1.7154780742952 0.0429610278520083 no 3183 0.0431288059591145 4396 5722064
SGTC_2680 butyl paraben 22.24 µM -1.72115939828686 0.0424457838417652 no 3184 0.0426109516041075 4669 7184 An antifungal and steroid mimetic.
SGTC_445 e6 berbamine 66 µM -1.72603761816447 0.0420073725734641 no 3185 0.0421703226421259 4592 6610268 A calcium/calmodulin antagonist.
SGTC_419 nsc-638432 893 µM -1.72688737370545 0.0419313802473105 no 3186 0.0420939462335112 4587 368090
SGTC_2053 5265679 138 µM -1.72961507567391 0.041688197828127 no 3187 0.0418495353644275 4519 764595
SGTC_655 k060-0012 42 µM -1.74771684564987 0.0401031794599692 no 3188 0.0402565351802374 4613 5994525
SGTC_1740 st038286 13.222 µM -1.75718663724042 0.0392937042687219 no 3189 0.0394430010903446 4602 716786
SGTC_731 3966-0296 387 µM -1.75743473293825 0.039272677178276 no 3190 0.0394218687285409 4621 660956
SGTC_2012 4023501 200 µM -1.7584185540475 0.039189384587144 no 3191 0.0393381592186237 4586 3477460
SGTC_1260 0700-1617 7.75 µM -1.75916216252971 0.0391265244122572 no 3192 0.0392749844863406 4580 2853078
SGTC_385 1494-0393 12.4 µM -1.76596647648779 0.0385551323403771 no 3193 0.0387007366141894 4577 3090647
SGTC_1435 4092-0789 56.7 µM -1.77134146614547 0.0381085910220482 no 3194 0.0382519679536588 4632 2248285
SGTC_2643 anethole 100 µM -1.77144340029988 0.0381001635076369 no 3195 0.0382434984411553 4622 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_718 1130-0073 349 µM -1.77527686320825 0.0377843298375687 no 3196 0.0379260918642942 4621 6740020
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.78212220030182 0.0372256683256363 no 3197 0.0373646531271671 4616 23847180
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.78449907038111 0.0370332729937973 no 3198 0.0371713028643412 4647 5106787 A p450 inhibitor.
SGTC_2074 5212007 75.395 µM -1.78573360165941 0.0369336652355536 no 3199 0.0370712010226789 4567 758611
SGTC_227 fluconazole 33.516 µM -1.78965509168693 0.0366187130978018 no 3200 0.0367546880258883 4621 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3249 9135183 49.47 µM -1.79367531899158 0.0362981151645189 no 3201 0.0364325034576703 4572 4902779
SGTC_2438 5259590 200 µM -1.79654872575186 0.036070382713231 no 3202 0.0362036453317241 4650 1201127
SGTC_2622 2-methoxyxanthone 59.94 µM -1.796603059751 0.0360660877588783 no 3203 0.0361993291585777 4590 71034 A hepatoprotective.
SGTC_904 1141-0088 396 µM -1.80437944967439 0.0354556911895688 no 3204 0.0355859212003823 4645 1378119
SGTC_3343 9148379 18.9835 µM -1.81817020586228 0.0343940482232118 no 3205 0.0345190611358757 4646 1955036
SGTC_3138 9097216 49.47 µM -1.82359073259601 0.0339839793512475 no 3206 0.0341069843386033 4583 25237486
SGTC_980 1473-0395 201 µM -1.82737300995448 0.03370023424624 no 3207 0.0338218522878729 4575 768876
SGTC_1663 st014140 55.4 µM -1.83107031006528 0.0334247512566727 no 3208 0.0335450246698574 4684 4207120
SGTC_2271 7849410 118.62 µM -1.83113852367902 0.0334196861846474 no 3209 0.0335399348932846 4579 972430
SGTC_1524 corynanthine 62.1 µM -1.83362869316463 0.0332352155817759 no 3210 0.0333545649938206 4680 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3281 9140613 49.47 µM -1.83438739729398 0.0331791781129421 no 3211 0.0332982545143816 4635 16013766
SGTC_2152 5568786 200 µM -1.83520301066547 0.0331190241914631 no 3212 0.033237807617304 4674 5399883
SGTC_3340 9146634 11.102 µM -1.83736427880871 0.0329600586017624 no 3213 0.0330780682475185 4633 4907387
SGTC_1009 4106-0057 9.87 µM -1.84094901094531 0.0326977811603212 no 3214 0.0328145155884511 4631 2928005
SGTC_927 2425-1185 123 µM -1.84245793597023 0.0325878962890665 no 3215 0.0327040969855825 4600 730375
SGTC_975 1335-0046 28.5 µM -1.8425745902877 0.0325794138373985 no 3216 0.0326955733463626 4628 16486740
SGTC_933 2914-0560 114 µM -1.84957673323 0.032073582532235 no 3217 0.0321872894068689 4652 463887
SGTC_411 enrofloxacin 100 µM -1.85008828569688 0.0320368838150134 no 3218 0.0321504130175146 4669 71188 A bacterial gyrase inhibitor.
SGTC_424 splitomicin 100 mM -1.85015397691171 0.0320321736476519 no 3219 0.0321456800491492 4629 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3255 9139072 49.47 µM -1.85046656948666 0.0320097680834194 no 3220 0.0321231660322565 4656 17646060
SGTC_1679 SEC14.276 6.7 µM -1.85437175739737 0.0317309467528841 no 3221 0.0318429962414999 4594 1005053 YMR079W SEC14
SGTC_350 k064-0020 19.8 µM -1.85663380006564 0.0315703620311794 no 3222 0.0316816358651104 4650 2790705
SGTC_2470 5664817 21.68 µM -1.86453678782444 0.0310145852569657 no 3223 0.0311231802076935 4703 2859561
SGTC_96 0929-0093 37.281 µM -1.86481518863402 0.0309951553253693 no 3224 0.0311036567824201 4653 6991579
SGTC_1043 0916-0009 19.3 µM -1.86576861043283 0.0309286911575888 no 3225 0.0310368728825044 4653 3101130
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.8674989359101 0.0308083694077634 no 3226 0.030915972640164 4620 61125 An anti-inflammatory.
SGTC_1568 digitonin 820 nM -1.87092633412631 0.0305711820623423 no 3227 0.0306776461681615 4619 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1754 st042065 16.137 µM -1.87217031832085 0.0304854691724197 no 3228 0.0305915220381923 4417 1126236 YIL048W NEO1
SGTC_3189 9110682 49.47 µM -1.87470509038034 0.0303114345668747 no 3229 0.0304166531089976 4637 17122418
SGTC_59 0330-0160 1.33 µM -1.87519526707507 0.0302778747685783 no 3230 0.0303829325290058 4607 4293482
SGTC_1476 4112-3294 3.34 µM -1.87725822894723 0.0301369720526473 no 3231 0.0302413551324214 4632 704369
SGTC_2820 7989630 71.43 µM -1.88604125199687 0.0295431515872911 no 3232 0.0296446979598293 4674 2984098
SGTC_3030 9087619 49.47 µM -1.88608211489951 0.0295404117096018 no 3233 0.0296419450189371 4642 25236973
SGTC_1798 st045719 60.953 µM -1.88933385979924 0.0293230558610053 no 3234 0.0294235536121438 4634 3980186
SGTC_3082 9117008 49.47 µM -1.88992126537972 0.0292839339825627 no 3235 0.0293842455020959 4673 41448529
SGTC_3282 9108498 15.4605 µM -1.89015898866809 0.0292681136680182 no 3236 0.0293683498920189 4632 16459645
SGTC_2205 7238770 200 µM -1.89989370267948 0.0286263467325589 no 3237 0.028723535305661 4680 279867
SGTC_210 3551-0445 56.827 µM -1.90081476507632 0.0285662359029324 no 3238 0.0286631397068472 4632 2865180 YOR207C RET1
SGTC_610 4215-0184 155 µM -1.92211703122733 0.0272050287475659 no 3239 0.0272955167569983 4677 5605015
SGTC_1712 st032288 53.4 µM -1.92510329235308 0.0270186042070914 no 3240 0.0271082185817195 4459 2883011
SGTC_2822 7994718 71.43 µM -1.92616254664981 0.0269527343998466 no 3241 0.0270420403906285 4668 1018011
SGTC_2208 7283366 200 µM -1.93208607902095 0.0265868452495538 no 3242 0.0266744411323514 4666 898663
SGTC_2658 polymyxin b sulfate 77.05 µM -1.95245499145825 0.0253602052297944 no 3243 0.025442104812439 4695 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1555 citronellol 128 µM -1.95459592676111 0.0252340740592737 no 3244 0.0253153912386475 4666 8842 A terpine precursor.
SGTC_103 0844-0104 51.839 µM -1.95830481058463 0.0250168128445019 no 3245 0.0250971283343666 4492 5375804
SGTC_692 k241-0027 77.8 µM -1.96006355013246 0.0249143377590614 no 3246 0.02499418144976 4691 3600480
SGTC_2308 7584454 197.62 µM -1.96482732348474 0.0246385372698437 no 3247 0.0247171133091815 4645 893577
SGTC_1406 3909-7906 11.9 µM -1.96711593233363 0.024506951091552 no 3248 0.024584923439788 4692 X1406
SGTC_1081 sertraline 6 µM -1.97059746146839 0.0243079080541781 no 3249 0.0243849686168277 4664 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2439 5492030 7.2 µM -1.97769228293449 0.0239064888176964 no 3250 0.0239817156875944 4671 5722370
SGTC_1269 0831-0796 3.05 µM -1.98772926327572 0.0233481323263917 no 3251 0.0234208203351622 4686 927758
SGTC_1921 5740136 50 µM -1.99343615142179 0.023035581323097 no 3252 0.0231068542721846 4616 1774243
SGTC_2497 7-hydroxyflavone 100 µM -2.01029446029225 0.0221328051386085 no 3253 0.0222000164288894 4675 5281894
SGTC_1350 1495-0454 146 µM -2.01568500226315 0.0218505131326773 no 3254 0.021916462439709 4692 1069057
SGTC_2377 9073351 62.6 µM -2.01718956112465 0.0217722673059255 no 3255 0.0218378675155346 4676 7337946 YHR072W ERG7
SGTC_2972 9093619 59.92 µM -2.01777035274723 0.0217421261381632 no 3256 0.0218075919532722 4661 25236256
SGTC_1032 k061-1018 98.7 µM -2.0205207345591 0.0215998686817663 no 3257 0.0216647008113454 4708 4005393
SGTC_2553 4-methylesculetin 85.09 µM -2.02110691874218 0.0215696514898982 no 3258 0.0216343491487806 4671 5319502
SGTC_1938 st074717 56.4 µM -2.0214229849327 0.0215533734323066 no 3259 0.0216179986707837 4597 17250979
SGTC_3246 9135460 32.98 µM -2.03184443507005 0.0210224330060778 no 3260 0.0210847035839383 4701 41446951
SGTC_1405 3909-7894 12 µM -2.03745792653669 0.0207410583273292 no 3261 0.0208020870301637 4697 7104060
SGTC_1294 1000-1494 117 µM -2.03814927981761 0.0207066260219465 no 3262 0.0207675030449259 4706 712797 YDL207W GLE1
SGTC_734 2023-0417 80 µM -2.0411843829798 0.0205560372931919 no 3263 0.0206162517010532 4690 3935732
SGTC_3 0833-0587 95.581 µM -2.04152433655393 0.0205392281875281 no 3264 0.0205993687089191 4597 5382644
SGTC_245 methotrexate 289.6 µM -2.0491392834608 0.020165745730562 no 3265 0.0202242485700894 4658 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2167 5876490 200 µM -2.04925792038007 0.0201599729324355 no 3266 0.0202184505195678 4686 686534
SGTC_1799 st045822 46.1415 µM -2.05101858083663 0.0200744648890984 no 3267 0.0201325686506913 4685 3674992
SGTC_2499 avocadenofuran 51.48 µM -2.06201474413183 0.0195473575991692 no 3268 0.0196031661337097 4658 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2845 9003024 42.97 µM -2.0703019145336 0.0191579170431072 no 3269 0.0192120402100946 4676 2990173
SGTC_2061 5245884 80.95 µM -2.07370063025347 0.0190001184799348 no 3270 0.0190535613316822 4675 573863
SGTC_3130 9127414 49.47 µM -2.08239189829499 0.0186016123654581 no 3271 0.0186533439315682 4716 1494646
SGTC_480 am 92016 50 µM -2.0902669944328 0.0182466953619318 no 3272 0.0182969112028926 4700 2129 K+ channel blocker.
SGTC_1322 1348-1070 12 µM -2.09456141892602 0.0180555958727253 no 3273 0.018104998943096 4699 6758089
SGTC_528 3492-0019 172 µM -2.10222387993755 0.0177188577419151 no 3274 0.0177668344548081 4700 2869262
SGTC_106 0092-0003 11.579 µM -2.10708811947889 0.0175078840458386 no 3275 0.0175549709801871 4665 1072148
SGTC_1093 fluphenazine 7.97 µM -2.11693387932948 0.0170874072316197 no 3276 0.017132729920219 4729 6602611 An atypical antipsychotic.
SGTC_732 3970-1727 52.7 µM -2.16911553996768 0.0150001979644331 no 3277 0.0150369565916243 4744 1275699
SGTC_3037 9091026 49.47 µM -2.17657556252785 0.0147204876589421 no 3278 0.0147561250711433 4609 25236398 YIL048W NEO1
SGTC_1327 1436-0082 2.18 µM -2.17834320276798 0.0146548721370003 no 3279 0.0146902475017129 4733 15992205
SGTC_356 1634-0012 32.5 µM -2.19054196167972 0.0142088733187615 no 3280 0.0142424775263991 4718 735457
SGTC_683 panaxydol 45 µM -2.21172386463148 0.0134621956016831 no 3281 0.0134928752588716 4727 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2914 7968218 45.32 µM -2.21372905138349 0.0133932991340379 no 3282 0.0134237116107043 4710 2977111
SGTC_1450 4112-4260 37.6 µM -2.22767047815123 0.0129226486567887 no 3283 0.012951248527763 4718 1633175
SGTC_370 0180-0345 38.7 µM -2.23016546793336 0.0128399462477069 no 3284 0.0128682299224085 4626 3989527
SGTC_162 k030-0015 37.8 µM -2.2323207386248 0.0127688735797941 no 3285 0.0127968860863928 4736 1809920 YMR134W ERG29
SGTC_1086 cerivastatin 2.18 µM -2.24371683221593 0.0123987044458996 no 3286 0.0124253132054184 4742 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1703 st026983 48.3 µM -2.2540899713586 0.0120698800209129 no 3287 0.0120952542232385 4748 1104023
SGTC_2913 7966556 36.57 µM -2.26205557112827 0.0118225315645684 no 3288 0.0118469850574917 4649 2976516
SGTC_2938 9059746 27.26 µM -2.26730930862041 0.0116618096198776 no 3289 0.0116856686106845 4703 6471769
SGTC_493 zm226600 134 µM -2.26799210977506 0.0116410613315752 no 3290 0.0116648437945326 4730 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1011 4112-3381 17.4 µM -2.27374065587373 0.011467647267982 no 3291 0.0114907920955892 4741 2877139
SGTC_723 4182-0001 115 µM -2.28739197239745 0.0110647996558839 no 3292 0.0110864772179023 4724 744821 YLR208W SEC13
SGTC_833 3852-0053 558 µM -2.30167657982047 0.0106564978118335 no 3293 0.0106767089552117 4749 3123681
SGTC_449 xestospongin c 11.1929 µM -2.31561239887858 0.0102708743958791 no 3294 0.0102897206284415 4752 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2854 9024559 71.43 µM -2.31648805845235 0.0102470552657171 no 3295 0.0102658178506838 4715 3163529
SGTC_3276 9139060 49.47 µM -2.32289919206517 0.0100741266207614 no 3296 0.0100922842755834 4772 4870619
SGTC_3287 9117173 37.0625 µM -2.33188731298762 0.00983597855566927 no 3297 0.00985331004006292 4754 2789709
SGTC_1781 st038725 66.3 µM -2.33383229054602 0.00978509661642731 no 3298 0.00980225264172233 4728 4270275 YIL048W NEO1
SGTC_3329 9141233 27.5565 µM -2.35376412684417 0.00927677547279518 no 3299 0.00929219978086682 4721 4909101 YNL103W MET4
SGTC_936 3005-4620 401 µM -2.36411209315956 0.00902209993896509 no 3300 0.00903667162132173 4748 777207
SGTC_628 1636-0253 16 µM -2.36443146375036 0.00901433823652323 no 3301 0.00902888409612042 4760 4456143
SGTC_2995 9067767 71.4286 µM -2.38346155551246 0.00856227885054652 no 3302 0.00857533787742887 4731 11673567
SGTC_3067 9117431 49.47 µM -2.38393272294999 0.00855134324211008 no 3303 0.00856436672843065 4735 17150885
SGTC_3339 9145883 14.936 µM -2.39040895482335 0.00840226957153583 no 3304 0.00841481064088262 4715 2030670
SGTC_1718 roemerine 11.9335 µM -2.41099786842636 0.00794338966134695 no 3305 0.00795447070978157 4431 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3093 9117344 49.47 µM -2.42670885382875 0.00760819929758476 no 3306 0.0076182388374693 4764 24824913
SGTC_823 0417-1665 178 µM -2.44462113530283 0.00724129368037088 no 3307 0.00725021883355443 4753 3429856
SGTC_2539 epi(13)torulosol 80 µM -2.45032488300078 0.00712778241257738 no 3308 0.0071363684804019 4715 6708597
SGTC_886 0866-0150 153 µM -2.45047637929566 0.00712478898030456 no 3309 0.00713336614331786 4764 271463
SGTC_2556 citropten 84.59 µM -2.47554334886377 0.0066445064379088 no 3310 0.00665168054564961 4730 2775 A potential DNA crosslinker.
SGTC_587 k089-0003 57 µM -2.48144600517196 0.00653566316533147 no 3311 0.00654252665239718 4732 9659696
SGTC_457 grayanotoxin iii 135 µM -2.48941779904819 0.00639116965614817 no 3312 0.00639762516259404 4614 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -2.50841629015073 0.00605814999434406 no 3313 0.00606368494750099 4766 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1468 k284-1086 134 µM -2.52215794146127 0.0058269534694239 no 3314 0.00583186627540738 4761 15996457
SGTC_2802 7925815 54.55 µM -2.54073735855205 0.00552682194342676 no 3315 0.00553094903207794 4737 1262923
SGTC_2398 5228213 48.84 µM -2.54080133994194 0.00552581257215094 no 3316 0.00552993706171696 4730 80771 YMR134W ERG29
SGTC_924 2046-0044 21.3 µM -2.54814494864725 0.00541104224878307 no 3317 0.00541487316166085 4749 3623589
SGTC_2608 thymoquinone 42.66 µM -2.5511665752873 0.00536443709500496 no 3318 0.00536814991186661 4727 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3101 9120531 49.47 µM -2.55329452868691 0.00533183034876934 no 3319 0.00533546093038358 4748 24824904
SGTC_2453 5731132 22.18 µM -2.57095520188498 0.00506794510562984 no 3320 0.00507092225530457 4766 1362040
SGTC_727 3032-0951 202 µM -2.57918319019606 0.00494902269385548 no 3321 0.00495171263022969 4781 3652836
SGTC_2250 alverine citrate 130 µM -2.68523326067443 0.00362411765641929 no 3322 0.00362396012520227 4679 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1620 st003704 16.5 µM -2.7103341584851 0.00336140491927694 no 3323 0.00336077262922793 4767 2834414
SGTC_1875 nocodazole 6 µM -2.73124449867756 0.00315576127437021 no 3324 0.00315478216351612 4789 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1664 st014217 9.02 µM -2.76142947578761 0.00287885577358217 no 3325 0.00287744720143554 4794 3982782
SGTC_1928 4'-methoxychalcone 40.3 µM -2.77354772422603 0.0027739944411595 no 3326 0.00277243533402701 4775 641818
SGTC_2552 juarezic acid 87.02 µM -2.80938904527041 0.00248371915186265 no 3327 0.00248178125523479 4770 1549512
SGTC_3222 9128301 49.47 µM -2.81289029705737 0.0024568898467681 no 3328 0.00245491992528467 4750 4911358
SGTC_1089 terbinafine 2.25 µM -2.8309315995921 0.00232275419957758 no 3329 0.00232063226848053 4795 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3166 9102297 49.47 µM -2.83810641090281 0.00227127907787277 no 3330 0.00226910251895054 4776 25237072
SGTC_3266 9136860 49.47 µM -2.86992366031125 0.00205523642776465 no 3331 0.00205285454543904 4624 4871271 YPR165W RHO1
SGTC_754 3474-0146 171 µM -2.89002665871336 0.00192852881736712 no 3332 0.00192604579049587 4781 24762078
SGTC_2582 agaric acid 100 µM -2.89759811557517 0.00188267635162106 no 3333 0.00188016049093842 4583 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_266 formosanin C 406 nM -2.90528389194484 0.00183714705623066 no 3334 0.0018346006589343 4731 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1876 myriocin 605 nM -2.92072244322553 0.00174870359382601 no 3335 0.00174610397614929 4765 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_171 k064-0041 9.68 µM -2.9460006833688 0.00161222346722171 no 3336 0.00160955844482328 4765 53325
SGTC_745 0469-0705 296 µM -2.95598678487556 0.00156103621908281 no 3337 0.0015583522231413 4798 3486736
SGTC_753 1322-0200 289 µM -2.96895082711563 0.00149679531613381 no 3338 0.00149409205115848 4798 5403907
SGTC_3285 9112818 20.8695 µM -3.03612806730475 0.00120090731070928 no 3339 0.00119818777991568 4786 17017947 YPR165W RHO1
SGTC_1039 k821-0043 94 µM -3.0974100723909 0.000978737414384401 yes 3340 0.000976098084684039 4757 15992768
SGTC_358 0075-0058 9.45 µM -3.12241810140062 0.00089944754319172 yes 3341 0.000896860018661742 4764 1069125
SGTC_2679 rapamycin 1 nM -3.29099803488135 0.000501242440712277 yes 3342 0.000499163053348201 4711 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_817 1391-0715 46 µM -3.37831298645801 0.000366436037582562 yes 3343 0.000364660101276204 4797 1353946
SGTC_2065 5221596 34.26 µM -3.47238921683134 0.00025938393680821 yes 3344 0.000257923932738141 4796 788581
SGTC_344 k064-0035 6.43 µM -3.65378321563336 0.000130142551037445 yes 3345 0.000129202232456075 4791 5088750
SGTC_2282 7944268 200 µM -3.70905164266507 0.000104829340110073 yes 3346 0.000104018498567479 4797 2970414
SGTC_1941 st076221 61.8 µM -3.76589642673027 8.36682478632687e-05 yes 3347 8.2976290646758e-05 4780 2828568
SGTC_2546 rhodinyl acetate 100 µM -3.80645771459488 7.11013753561018e-05 yes 3348 7.04856909134164e-05 4806 6708682
SGTC_1930 st074634 34.3 µM -3.86949021023119 5.50421120344447e-05 yes 3349 5.45315801487168e-05 4789 684253 YOR116C RPO31
SGTC_3296 9122258 64.045 µM -4.04920442988021 2.59846776152208e-05 yes 3350 2.56960193308296e-05 4806 4730474
SGTC_1844 rapamycin 4 nM -4.57515850469139 2.42076130516326e-06 yes 3351 2.37929788105869e-06 4771 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2285 7945142 200 µM -4.67210032281182 1.51853163354885e-06 yes 3352 1.49067633445732e-06 4808 2970608
SGTC_3204 9114183 49.47 µM -4.69181390203968 1.379620637352e-06 yes 3353 1.35396696846789e-06 4802 17027248
SGTC_922 1866-0035 480 µM -4.8167608604821 7.4459104485675e-07 yes 3354 7.29536892096545e-07 4805 3156169
SGTC_3205 9113483 49.47 µM -4.84863010918066 6.34685278244471e-07 yes 3355 6.21584905596008e-07 4806 17018033
SGTC_163 TUB2.036 7.546 µM -5.89241614258283 1.97485139551806e-09 yes 3356 1.90294623960216e-09 4808 15992207 YJR013W GPI14