SGTCid condition conc unit PRM4|YPL156C.score PRM4|YPL156C.strain.pval PRM4|YPL156C.strain.significant PRM4|YPL156C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_67 0335-0847 266 µM 7.43090424194427 2.84533066026626e-17 yes 1 5.39288881201162e-14 44 4552207 YOR254C SEC63 SGTC_2433 5607874 27.82 µM 6.0515924199946 4.65883133647793e-12 yes 2 7.17104820133238e-10 3 2252428 SGTC_2299 7976368 114.88 µM 6.01172613459746 6.36261302739267e-12 yes 3 9.17791156351542e-10 8 2979718 SGTC_1927 st060202 13.8 µM 5.50325293282709 2.84902080047859e-10 yes 4 1.86423453363964e-08 3 688887 SGTC_2321 7390090 138.78 µM 4.79954746134369 3.23447470844231e-08 yes 5 7.95122741267092e-07 13 649046 SGTC_49 0717-0965 32.132 µM 4.63675982066604 8.8581507538919e-08 yes 6 1.76956623621021e-06 11 5889349 YGL099W LSG1 SGTC_3210 9128157 49.47 µM 4.58664010914851 1.20004774482646e-07 yes 7 2.25218078150161e-06 31 17590849 SGTC_2967 9089538 49.85 µM 4.40475107689479 3.5191441342335e-07 yes 8 5.29527080466377e-06 22 728216 SGTC_2211 7117706 200 µM 4.13849811046611 1.57968970850692e-06 yes 9 1.7479337563923e-05 9 822771 SGTC_2441 5730946 39.09 µM 4.05111503139215 2.53734273540007e-06 yes 10 2.54870692102362e-05 14 1774275 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 3.96007549696076 4.11610784232237e-06 yes 11 3.74630360534683e-05 31 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1088 bifonazole 369 nM 3.89832850484434 5.68185333853351e-06 yes 12 4.84294801702442e-05 17 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2806 7952793 58.44 µM 3.80232569672605 9.29297702893591e-06 yes 13 7.16720559976616e-05 26 2972490 SGTC_158 k038-0087 26.446 µM 3.76283706740913 1.13403497508893e-05 yes 14 8.39983288794044e-05 153 X158 SGTC_505 gw-5074 63.9 µM 3.71752554901032 1.421785325567e-05 yes 15 0.000100591823200946 67 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2506 ethyl hematommate 54.16 µM 3.68745340430291 1.64973301409197e-05 yes 16 0.000113254776839211 20 3940691 An allergen. SGTC_1183 1254-0324 198 µM 3.57886328399031 2.79666516813398e-05 yes 17 0.000172545962684553 34 5799357 SGTC_1731 st035964 63 µM 3.55067015086005 3.19991838496231e-05 yes 18 0.000192125832891969 44 6739575 SGTC_2998 9066762 71.4286 µM 3.40488255612497 6.32368679435639e-05 yes 19 0.00033096257287093 43 4945196 SGTC_2398 5228213 48.84 µM 3.40368674403661 6.35844260495263e-05 yes 20 0.000332414752926225 68 80771 YMR134W ERG29 SGTC_1725 st036284 20.55 µM 3.39698011072714 6.55672847491733e-05 yes 21 0.000340669594740377 55 707914 SGTC_1644 st010134 20.9 µM 3.39068635581597 6.74809468380276e-05 yes 22 0.000348589188849837 23 3818134 SGTC_1338 1486-1223 76 µM 3.36190385427206 7.69225781909063e-05 yes 23 0.00038703535454135 40 3444526 SGTC_1239 0337-0584 35.4 µM 3.33662251572117 8.62284128541526e-05 yes 24 0.000424015213145543 83 914301 YML130C ERO1 SGTC_533 1222-0222 6.71 µM 3.26836430675891 0.000116919694353317 yes 25 0.000540855162405002 60 3982874 SGTC_1348 1493-0373 93.8 µM 3.18078507720357 0.000171391753641323 yes 26 0.000734382751031829 38 3010129 SGTC_51 1013-0126 23.419 µM 3.1672243128906 0.000181698512044264 yes 27 0.000769507782303731 48 1627850 SGTC_1423 4048-0112 5.59 µM 3.14188186709449 0.000202530339831782 yes 28 0.000839328749263011 57 X1423 SGTC_650 1328-0195 38 µM 3.10944197250612 0.000232456881297693 yes 29 0.000937205495026861 51 2780821 SGTC_3155 9099265 49.47 µM 3.08565230373594 0.000256972566677242 yes 30 0.00101553087371791 62 25236499 SGTC_263 alizarin 107.927 µM 3.06715264215053 0.000277680192087502 yes 31 0.00108054234863457 123 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2213 7173844 200 µM 3.06321960428799 0.000282278438161138 yes 32 0.00109484652133818 48 892728 SGTC_1552 6-methylflavone 10.6 µM 3.050435133049 0.000297719712908898 yes 33 0.00114255017723925 38 689013 SGTC_664 1222-0054 14.9 µM 3.03243270590079 0.00032079967993099 yes 34 0.00121295590343401 75 6813991 SGTC_1421 4029-0249 71.4 µM 2.96586041180002 0.000421389957308029 yes 35 0.00150918725829046 49 2894095 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.92947079044272 0.00048804528615973 yes 36 0.00169769861739546 52 7104 SGTC_2328 6201408 200 µM 2.87970494536712 0.00059507200122423 yes 37 0.00199023747455932 63 2890418 SGTC_2278 7948257 134.34 µM 2.85979612171956 0.000643663710122816 yes 38 0.00211956720652902 57 1247028 SGTC_2323 6148992 148.28 µM 2.83592509648858 0.000706745547025454 yes 39 0.00228465805493707 78 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2763 lisinopril 49.32 µM 2.78923040717484 0.000846914728504082 yes 40 0.00264167314617801 48 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_625 k213-0058 121 µM 2.78741063504989 0.000852862847305461 yes 41 0.00265655530801386 237 3655420 SGTC_103 0844-0104 51.839 µM 2.73703402941229 0.00103358160735577 no 42 0.00309979398243617 245 5375804 SGTC_2424 5537928 59.2 µM 2.73670261856777 0.00103487892044707 no 43 0.00310291823855494 118 5382802 SGTC_3219 9131112 49.47 µM 2.72703438733272 0.00107338911217547 no 44 0.00319531893716269 94 17612988 YMR079W SEC14 SGTC_1508 1080-0625 72.9 µM 2.72305113805282 0.00108963382368229 no 45 0.00323410224147625 68 767111 SGTC_2271 7849410 118.62 µM 2.71597741953404 0.00111903880032807 no 46 0.00330402124104022 67 972430 SGTC_3150 9097574 49.47 µM 2.71558439809936 0.00112069369256885 no 47 0.00330794555946735 57 17217476 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.70198064039002 0.00117937579624959 no 48 0.00344638878273578 115 4174840 SGTC_2461 5755302 26.15 µM 2.69960137801342 0.00118992364673959 no 49 0.00347113005291015 114 2788904 SGTC_2208 7283366 200 µM 2.69008183944475 0.0012329957947445 no 50 0.00357172490866985 59 898663 SGTC_159 3970-0959 50 µM 2.64209704328653 0.00147263160912689 no 51 0.00411972221049635 220 6615653 SGTC_276 colchicine 750 µM 2.62957195751416 0.00154181806393345 no 52 0.00427462184076488 92 2833 A microtubule depolymerizer. SGTC_552 k242-0005 476 µM 2.62659210113154 0.00155870887204324 no 53 0.00431223246087929 86 4088318 SGTC_603 3794-0023 45.9 µM 2.61710736722683 0.00161360068035811 no 54 0.00443392215308871 76 3802260 SGTC_12 0849-0099 9.267 µM 2.61423415370509 0.00163057336210409 no 55 0.0044713862511353 84 6071388 SGTC_2397 5161689 200 µM 2.60554962384827 0.00168286822182192 no 56 0.0045863492627555 125 2259942 SGTC_638 3970-0837 4.09 µM 2.59638347803499 0.00173971582303277 no 57 0.0047105426992744 130 4118451 YLR208W SEC13 SGTC_759 3486-0358 89.3 µM 2.58658027995755 0.0018024437744393 no 58 0.00484667934583269 104 875103 SGTC_359 0081-0058 15.9 µM 2.58117600526807 0.00183789726342763 no 59 0.00492321837341197 148 3494159 SGTC_2255 7941087 197.44 µM 2.56543360185661 0.00194481503695481 no 60 0.00515234708744815 118 935561 SGTC_1924 st058459 75.1 µM 2.52636094716593 0.00223502339080476 no 61 0.00576255013801032 77 688683 SGTC_2808 7946468 45.46 µM 2.52281465655876 0.00226321516149731 no 62 0.00582098717797204 126 2970879 SGTC_974 1326-0144 138 µM 2.49155900063613 0.00252596847407705 no 63 0.00635919207802776 152 5411856 SGTC_2217 6934799 96.0675 µM 2.47377310786137 0.00268751214219561 no 64 0.00668472872371258 65 675606 SGTC_3244 9134489 49.47 µM 2.45829623983273 0.00283561184669813 no 65 0.00697989843302705 123 16584271 SGTC_2331 7980721 200 µM 2.45776716525514 0.00284080229914509 no 66 0.00699018903450288 128 2981221 SGTC_2640 pentamidine 10.38 µM 2.45571136070286 0.00286105207924068 no 67 0.0070303020561256 147 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1646 st011709 75.6 µM 2.44573940094183 0.00296113552973379 no 68 0.00722777215438944 91 5757843 SGTC_2739 tacrine 100.86 µM 2.44069425871061 0.00301296359570855 no 69 0.00732952976545613 104 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3019 9081971 49.47 µM 2.4384516810596 0.00303626255374313 no 70 0.00737516525014935 96 16451803 SGTC_3313 9133968 57.047 µM 2.43832243096407 0.00303761031337332 no 71 0.00737780304953958 94 1494643 SGTC_116 0155-0182 31.788 µM 2.36371764258749 0.00391170830199403 no 72 0.00904629801420764 268 771486 SGTC_1228 0124-0032 52.5 µM 2.36126875421507 0.00394388216776495 no 73 0.00910626325236971 144 X1228 SGTC_2561 acetosyringone 100 µM 2.30935068061061 0.00468414927729555 no 74 0.0104620647256917 176 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_655 k060-0012 42 µM 2.29888446775143 0.00484759096399438 no 75 0.0107557503119968 132 5994525 SGTC_2708 st078559 56 µM 2.29871612003215 0.00485026093489316 no 76 0.0107605322775915 73 17250902 SGTC_2161 5662504 8.5105 µM 2.28714380740305 0.00503696777605069 no 77 0.0110937153132809 150 2859334 SGTC_1720 st037298 9.481 µM 2.24230047980882 0.00582234729420687 no 78 0.0124709793866266 176 597396 SGTC_720 r052-1644 49.9 µM 2.23988301616236 0.00586761727982851 no 79 0.0125492592599601 143 1422863 YOR257W CDC31 SGTC_822 1487-0950 154 µM 2.23970628262579 0.00587093904741614 no 80 0.0125549987168733 148 1958375 SGTC_727 3032-0951 202 µM 2.23133412018679 0.00603022023631258 no 81 0.0128295025822405 163 3652836 SGTC_503 tyrphostin 8 294 µM 2.23069389356196 0.00604255681475887 no 82 0.012850706203904 188 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2420 aureobasidin a 50 nM 2.22993427944787 0.00605722289126997 no 83 0.0128759031212582 213 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_468 gf-109203x 121 µM 2.21861410406147 0.00627955324547598 no 84 0.013256494593488 72 2396 A protein kinase C inhibitor. SGTC_2330 7979373 200 µM 2.21535202592896 0.00634494802452705 no 85 0.0133679557304397 200 1863007 SGTC_1115 galangin 695.678 nM 2.19739919078241 0.00671574799603622 no 86 0.0139959745145507 181 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1169 aniline yellow 25.8 µM 2.18649735987746 0.00695014714305877 no 87 0.014389618816121 132 6051 A DNA damaging agent. SGTC_399 oxolinic acid 75 µM 2.17504686445018 0.00720409213863027 no 88 0.0148133023350109 135 4628 A DNA gyrase inhibitor. SGTC_2716 st080858 38.6235 µM 2.17342548722034 0.00724070408307109 no 89 0.0148741541477848 149 5296050 SGTC_2513 baicalein 25.65 µM 2.1438895267924 0.00793697024720946 no 90 0.0160208697849101 179 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_921 1561-0023 372 µM 2.11127190436458 0.0087736762107923 no 91 0.0173744737537723 179 24050882 SGTC_3238 9133470 49.47 µM 2.10404444385349 0.00896921358631672 no 92 0.0176872851620603 144 3534688 SGTC_3203 9113543 49.47 µM 2.09987563647214 0.00908372717616355 no 93 0.0178698912323049 211 17018012 SGTC_3024 9090631 49.47 µM 2.09676327230386 0.00917005391045795 no 94 0.0180072681638565 123 25236383 SGTC_2764 methyldopa 94.69 µM 2.09503038745895 0.00921842899533775 no 95 0.0180841456426175 205 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_754 3474-0146 171 µM 2.08138968340885 0.00960708349688096 no 96 0.0186991261004549 217 24762078 SGTC_1803 st050068 52.4 µM 2.0650913941454 0.0100901749149378 no 97 0.0194571767735546 472 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2524 avocatin b 10.57 µM 2.063146883329 0.0101492034413665 no 98 0.0195493374730732 164 6710748 SGTC_1717 st033143 58.0435 µM 2.06212358010527 0.0101803881545686 no 99 0.0195979859590611 244 674616 SGTC_732 3970-1727 52.7 µM 2.05556648916234 0.0103822034022983 no 100 0.0199121603322915 159 1275699 SGTC_3300 9124615 50.48 µM 2.04659025656623 0.0106641257279923 no 101 0.0203491661586873 231 24824903 SGTC_3207 9114163 49.47 µM 2.02559248410033 0.0113497862171055 no 102 0.0214032811867115 267 849233 SGTC_2025 5147754 141 µM 2.02492823371572 0.0113720878237881 no 103 0.0214373669884673 163 315777 YLR208W SEC13 SGTC_74 000s-0487 160.283 µM 1.99792887711028 0.0123113775898935 no 104 0.0228621857116299 230 677548 SGTC_563 tetrahydrosecaminediol 614 µM 1.9914337435675 0.0125471217547807 no 105 0.0232166113033846 227 334274 A psychoactive constituent of the cannabis plant. SGTC_1797 st048695 56.8 µM 1.99035565097121 0.0125866274960489 no 106 0.0232758858158324 240 592262 YIL048W NEO1 SGTC_1818 st052136 56.3 µM 1.99032262162149 0.0125878395250875 no 107 0.0232777038087135 260 674169 SGTC_368 fentichlor 4.58 µM 1.98515185360807 0.0127788337429859 no 108 0.023563789561245 204 7329 A pesticide. SGTC_1101 ebselen 5.29 µM 1.98358691178041 0.012837130473204 no 109 0.023650954726889 227 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1885 st057546 99.9 µM 1.98083189602761 0.0129403185215646 no 110 0.0238050642859822 236 702008 SGTC_1388 3346-4487 254 µM 1.97996694439045 0.0129728625384308 no 111 0.0238536215702876 242 3345614 SGTC_2220 6782180 200 µM 1.96894658494957 0.0133937408726201 no 112 0.024479612621305 133 833803 SGTC_2430 5571206 200 µM 1.96331784268103 0.0136132210559967 no 113 0.0248046267345486 268 1731771 SGTC_2347 9049783 174.81 µM 1.94724505506579 0.0142571080783903 no 114 0.0257526812370225 283 6467988 YPL169C MEX67 SGTC_672 1441-0018 53.7 µM 1.93858293068567 0.0146148743290455 no 115 0.0262760718374185 219 251141 SGTC_1702 st027038 51 µM 1.93685380146997 0.0146872090682718 no 116 0.0263816085410475 235 5521182 SGTC_1263 0774-1208 64.8 µM 1.9337059012816 0.0148196862501911 no 117 0.0265746489329345 312 906585 SGTC_1590 st077108 57.8 µM 1.9239854791442 0.0152352686208199 no 118 0.0271782018105234 187 5489485 SGTC_137 0438-0332 85.389 µM 1.91893961660293 0.0154549167677111 no 119 0.0274959880802116 409 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_823 0417-1665 178 µM 1.90749603002686 0.0159631544088102 no 120 0.0282281923199348 264 3429856 SGTC_1903 st060211 78.3 µM 1.90605508343947 0.016028154898752 no 121 0.0283215297037812 270 688960 SGTC_686 1319-0111 510 µM 1.90228326263889 0.0161993751882349 no 122 0.0285670663083881 250 4562600 SGTC_576 1073-0113 22.7 µM 1.89010948166571 0.0167627297084231 no 123 0.0293716596394293 388 5439563 SGTC_3072 9116419 49.47 µM 1.88556703435054 0.0169771877997538 no 124 0.0296766616073899 226 17170162 SGTC_2807 7945238 51.95 µM 1.88000375467654 0.0172430331850719 no 125 0.0300537831050541 284 17148797 SGTC_2894 9048625 32.47 µM 1.87183173133108 0.0176399839989337 no 126 0.0306149434023879 236 4092861 SGTC_2118 5526350 200 µM 1.86556307825957 0.0179497416410548 no 127 0.0310512596596703 262 743594 SGTC_1578 josamycin 24.2 µM 1.86184708162977 0.0181355436859127 no 128 0.0313123239683472 246 5282165 A P450 substrate. SGTC_3156 9099931 49.47 µM 1.85424361812296 0.0185208343886646 no 129 0.0318521571991648 244 18111053 SGTC_827 3253-0474 693 µM 1.84701466697503 0.0188935891103103 no 130 0.0323725073074413 273 5402065 SGTC_256 clotrimazole 625 nM 1.84616872722229 0.0189376235478575 no 131 0.0324338551027103 285 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2308 7584454 197.62 µM 1.8448107354951 0.0190084948138814 no 132 0.0325325376094028 305 893577 SGTC_1074 carmofur 3.8 µM 1.83771469780091 0.0193825041779262 no 133 0.0330522284626726 332 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2275 7947463 200 µM 1.83771013216564 0.0193827468162579 no 134 0.0330525650241909 240 1225414 SGTC_959 1222-0044 107 µM 1.8241178657197 0.0201166339579636 no 135 0.0340671275651425 280 6083612 SGTC_620 0109-0052 432 µM 1.81573595274868 0.020580842823552 no 136 0.0347054430830668 269 493037 SGTC_562 3772-2733 112 µM 1.81241760833686 0.0207671112780486 no 137 0.0349608470565631 354 2876874 YIL048W NEO1 SGTC_634 1611-4317 11.2 µM 1.81036678949303 0.0208829419927977 no 138 0.0351194629390232 303 2843522 SGTC_1216 1165-0504 9.65 µM 1.80794183096014 0.0210206094013739 no 139 0.0353077771811326 287 6304004 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.80615270503085 0.0211226715892894 no 140 0.0354472450614977 155 1241132 A phosphatase inhibitor. SGTC_1814 st052110 31.539 µM 1.8060852107248 0.0211265300504025 no 141 0.0354525152802026 243 674163 SGTC_598 3937-0236 20.2 µM 1.80260532156267 0.0213262750816133 no 142 0.0357251103429809 319 1379313 SGTC_559 1550-0661 158 µM 1.80244736769972 0.0213353793661037 no 143 0.0357375242060969 267 5830875 SGTC_1726 st035556 14.5795 µM 1.79587096152534 0.0217173636158845 no 144 0.0362575208456272 331 5919439 SGTC_2003 4023581 200 µM 1.79425176263538 0.021812294649622 no 145 0.0363864967831702 297 16641307 SGTC_1179 1021-1431 9.29 µM 1.79146455485893 0.021976525061761 no 146 0.0366093888327313 365 2840958 SGTC_3068 9116768 49.47 µM 1.79133485066834 0.0219841929642839 no 147 0.0366197883711411 276 41904888 SGTC_1568 digitonin 820 nM 1.78775715729846 0.0221965925751214 no 148 0.0369075978567386 316 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1913 st060213 96.1 µM 1.78744526670748 0.0222151906015726 no 149 0.0369327754611486 329 688959 SGTC_1946 st076057 65.1 µM 1.78120586470106 0.0225900175447989 no 150 0.0374394129680688 169 953009 SGTC_182 3448-4371 550.524 µM 1.77914217305286 0.0227151596415148 no 151 0.0376082280292408 312 3491403 SGTC_1203 3992-3522 103 µM 1.77477281429475 0.0229820461567401 no 152 0.0379677034326641 316 5322312 SGTC_1961 st076550 68.7 µM 1.77312316918692 0.0230834932815172 no 153 0.0381041497733933 255 1579337 SGTC_293 4049-0273 38.5 µM 1.76412863224929 0.0236432802696748 no 154 0.0388551624392161 255 1380311 SGTC_73 0327-0325 16.231 µM 1.76362357170184 0.0236750490238725 no 155 0.0388976882139186 365 53298 SGTC_1654 st012436 41.8 µM 1.75626631646143 0.0241419115590373 no 156 0.0395214729327733 256 4323132 SGTC_1011 4112-3381 17.4 µM 1.75498301483423 0.0242241318196303 no 157 0.0396311065505029 322 2877139 SGTC_1866 st057638 64 µM 1.75205423153932 0.0244126581153427 no 158 0.0398822415862468 265 688802 SGTC_884 0851-0618 334 µM 1.74955251149381 0.0245746682472873 no 159 0.0400977800920934 323 9642473 SGTC_3251 9135047 49.47 µM 1.74822265224655 0.0246611559230418 no 160 0.0402127403077813 216 17682963 SGTC_2052 5265182 7.135 µM 1.74286459878311 0.0250122096278344 no 161 0.0406786345541861 318 1239884 SGTC_1641 st009299 47.1 µM 1.73766552567987 0.0253568424677482 no 162 0.0411348832960511 218 4046054 SGTC_1240 0356-0016 42.1 µM 1.73534227148495 0.0255121259270467 no 163 0.0413400993153956 319 4305613 SGTC_2679 rapamycin 1 nM 1.73150292484569 0.0257704882257007 no 164 0.0416810518358071 458 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1609 st001574 46.4 µM 1.73129731951845 0.025784385637247 no 165 0.0416993746456408 299 3960012 SGTC_1507 4075-3230 155 µM 1.72604203292152 0.0261417390767741 no 166 0.042169925552183 243 659771 SGTC_1032 k061-1018 98.7 µM 1.71881445675759 0.0266399624932501 no 167 0.0428240811433728 364 4005393 SGTC_37 0566-0070 1.56 µM 1.71481441817514 0.0269190929268377 no 168 0.0431896286122045 354 1626686 SGTC_1008 4106-0037 6 µM 1.70951598837734 0.0272925825934271 no 169 0.0436777063420049 286 2905394 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.70243167627423 0.027798704274227 no 170 0.0443372381217967 297 279621 SGTC_1117 retinoic acid 1.10837 µM 1.69788065259763 0.0281279485180194 no 171 0.0447651447772582 341 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2692 st077426 47.7 µM 1.69242903761786 0.0285266136697027 no 172 0.0452820998561734 339 25238571 SGTC_1282 0886-0010 32.4 µM 1.69076360540203 0.028649336475045 no 173 0.0454409803935023 353 2836211 YNL267W PIK1 SGTC_1428 4049-0204 61.7 µM 1.6890038340812 0.0287794877322069 no 174 0.0456093476024042 317 X1428 SGTC_1791 st048313 56.1 µM 1.68838516371614 0.0288253607229579 no 175 0.0456686582914626 276 1204976 SGTC_725 1497-0963 19 µM 1.68314132236681 0.0292166258480036 no 176 0.0461738683558662 317 3549977 SGTC_2712 st079126 47.7 µM 1.67674121045956 0.02970013278709 no 177 0.0467965491398352 306 3152970 SGTC_2048 5246248 200 µM 1.67641265880572 0.0297251318752609 no 178 0.0468286955386731 270 677046 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.67195019429813 0.0300664076579361 no 179 0.0472670718548142 319 688798 SGTC_2426 5582046 32.21 µM 1.67085138518567 0.0301509378895603 no 180 0.0473755179796471 364 2251934 SGTC_2690 usnic acid 100 µM 1.65929033161274 0.0310523161244428 no 181 0.0485286512894379 400 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2218 6965428 192.983 µM 1.65690358321831 0.0312411530152472 no 182 0.0487694849129189 317 675684 SGTC_1560 lithocholic acid 53.1 µM 1.65328594982434 0.0315291862071276 no 183 0.049136340547585 225 9903 A bile acid which acts as a detergent. SGTC_1379 2144-0755 36.5 µM 1.65316218666421 0.0315390788378929 no 184 0.0491489299615363 381 5392327 SGTC_1315 1237-0019 3.69 µM 1.65152402345955 0.0316702623114075 no 185 0.0493158097440227 329 825140 SGTC_336 4111-0029 111 µM 1.6428053012582 0.0323760612308591 no 186 0.0502116115143764 293 3131175 SGTC_788 1182-0090 188 µM 1.64201095481436 0.0324410053529951 no 187 0.0502938669089683 473 5715185 SGTC_729 4092-0585 94.1 µM 1.63691516765563 0.03286018713537 no 188 0.0508240981198841 323 2169061 SGTC_1837 st055472 66.5 µM 1.63615196044791 0.0329233516556339 no 189 0.0509038938518236 353 676091 SGTC_2738 aclarubicin 5.55 µM 1.63402500331278 0.0330999110079889 no 190 0.0511268003232243 237 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3173 9105693 49.47 µM 1.6335664890844 0.0331380744439605 no 191 0.051174954531559 376 17096658 SGTC_3289 9119912 71.43 µM 1.62920950062143 0.0335025308173892 no 192 0.0516343382112002 351 17014829 SGTC_2827 7993847 71.43 µM 1.62654344387224 0.0337271658045201 no 193 0.0519170496814453 298 2985692 SGTC_1403 3909-7815 62.9 µM 1.62566321871333 0.0338016028635999 no 194 0.0520106593088417 295 6615483 SGTC_1895 st058434 18.3 µM 1.62459068009295 0.0338924857161967 no 195 0.0521249021541221 354 5393175 SGTC_1332 1480-0653 17.5 µM 1.61956965600315 0.0343206250736463 no 196 0.0526623761280684 368 5749438 SGTC_1490 4089-0339 670 nM 1.596271443167 0.0363657882963632 no 197 0.0552141014591086 291 742542 SGTC_1120 ficusin 1.78878 µM 1.59591203614066 0.0363981024420522 no 198 0.0552542169505034 356 6199 A DNA cross-linker. SGTC_470 aa-861 153 µM 1.59129624551251 0.0368151990842506 no 199 0.0557714606852834 427 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.58786862693797 0.0371274511177552 no 200 0.0561580245369823 380 390807 SGTC_384 k007-0144 5.16 µM 1.58662194054352 0.037241558186073 no 201 0.0562991475857145 444 6824886 SGTC_1876 myriocin 605 nM 1.58630695383643 0.0372704336777663 no 202 0.0563348478178153 357 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_716 1683-5115 658 µM 1.5838077797832 0.0375001870695458 no 203 0.0566187341757351 433 723597 SGTC_2458 5808907 16.39 µM 1.581711549519 0.0376937878827166 no 204 0.0568577174488771 354 2731747 SGTC_1433 4060-0023 7.6 µM 1.58055172653199 0.0378012553716403 no 205 0.0569902854324673 374 3840627 SGTC_429 1112-0049 25.5 µM 1.57841767319586 0.0379996469098113 no 206 0.057234843852457 368 2836170 SGTC_36 0335-0881 14.2 µM 1.57433570744724 0.038381491600149 no 207 0.0577049294099533 475 23828853 SGTC_442 cape 100 µM 1.57192638786645 0.0386083338947771 no 208 0.0579838119896508 342 5281787 SGTC_2886 9058944 51.95 µM 1.57045796427985 0.0387471239335837 no 209 0.05815430322434 195 4949929 SGTC_1275 0867-0008 21.1 µM 1.57029808489272 0.0387622596540385 no 210 0.0581728897631494 396 3422836 SGTC_3039 9090270 49.47 µM 1.5660076049193 0.0391702398216977 no 211 0.0586734183937051 340 17173750 SGTC_298 1391-0729 10 µM 1.56220839375018 0.0395344168334394 no 212 0.059119451936389 353 3237558 SGTC_2736 butenafine 14.65 µM 1.56159624514176 0.0395933517243748 no 213 0.0591915673021382 437 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_106 0092-0003 11.579 µM 1.55875323716662 0.0398680008066425 no 214 0.0595273980327723 298 1072148 SGTC_3265 9137266 49.47 µM 1.5585569890796 0.0398870163705227 no 215 0.0595506348552736 318 17224265 SGTC_2329 6138490 200 µM 1.55062322395712 0.0406619566836877 no 216 0.0604960016356259 367 720019 SGTC_274 sirtinol 40.1 µM 1.54950779872006 0.0407718804510751 no 217 0.0606298491212169 387 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2642 cholecalciferol 100 µM 1.54445815638006 0.0412725367343254 no 218 0.0612386903201016 358 9821465 A vitamin D precursor, similar to steriods. SGTC_2375 9072683 200 µM 1.53725358206933 0.0419954633810965 no 219 0.0621156118021948 436 16798029 SGTC_2002 4023503 131 µM 1.53541152222033 0.0421819369045726 no 220 0.0623413876111919 507 4736863 YCR052W RSC6 SGTC_3060 1327-0027 12.5 µM 1.53487581909006 0.0422362922427072 no 221 0.0624071671338728 372 16000455 YPR107C YTH1 SGTC_2163 5671233 125 µM 1.53344597767176 0.0423816492317533 no 222 0.0625830038072225 439 701023 SGTC_164 4100-3994 89.624 µM 1.53339150415821 0.0423871949747189 no 223 0.0625897103899667 466 4615967 SGTC_3226 9131256 49.47 µM 1.53075192797902 0.0426566243872554 no 224 0.0629153572788501 240 17178073 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.53052844348766 0.0426794995504092 no 225 0.0629429892589789 380 689007 SGTC_2376 9072922 81.32 µM 1.52811629133488 0.0429270315006802 no 226 0.0632418336411935 436 17087968 SGTC_2801 7907800 81.82 µM 1.52663622847656 0.0430794870629317 no 227 0.0634257465468061 430 6620925 SGTC_1781 st038725 66.3 µM 1.52301536622625 0.0434543024611817 no 228 0.0638774305383975 519 4270275 YIL048W NEO1 SGTC_1096 rimcazole 32.2 µM 1.51925088623655 0.0438467712442422 no 229 0.0643496785342163 366 18528119 A dopamine reuptake inhibitor. SGTC_1799 st045822 46.1415 µM 1.5191264431793 0.043859793814624 no 230 0.0643653359179213 386 3674992 SGTC_2634 4'-methoxyflavone 100 µM 1.51687918084866 0.0440954999980413 no 231 0.0646485954310707 400 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2758 dehydroepiandrosterone 69.35 µM 1.51179461773632 0.0446325691562433 no 232 0.0652930595353754 450 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2828 7998861 71.43 µM 1.50731109459832 0.0451105119165208 no 233 0.0658654675538787 330 2988188 SGTC_2684 capsaicin 100 µM 1.49850258453939 0.046061488152193 no 234 0.0670013608180147 395 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2519 cryptotanshinone 88.04 µM 1.49210367233097 0.0467623685678288 no 235 0.0678359846643376 378 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1500 4488-1866 171 µM 1.47990680126974 0.0481219865436734 no 236 0.0694490601919272 484 2900003 SGTC_86 0417-1630 471.922 µM 1.47867347499879 0.0482612119701983 no 237 0.0696138024152567 581 3634867 SGTC_1851 st056236 18.9 µM 1.47647124566927 0.0485106143627138 no 238 0.0699087144497622 429 5393171 SGTC_153 4077-0274 519.67 µM 1.47374204483848 0.0488211250948877 no 239 0.0702755288995032 404 3121976 SGTC_685 1278-0033 54.9 µM 1.47254873536315 0.0489573902245285 no 240 0.0704363783220761 472 3590572 SGTC_2288 7946289 167.31 µM 1.47146825381731 0.0490810333992711 no 241 0.0705822633915023 495 1246052 SGTC_2493 resveratrol 26.09 µM 1.46170167620469 0.0502100061755413 no 242 0.0719114888627542 386 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_318 1488-0629 67.2 µM 1.46081016964911 0.0503140830459125 no 243 0.072033772086332 408 3662576 SGTC_636 0kpi-0074 126 µM 1.45931105672128 0.0504894810782012 no 244 0.0722397567888478 415 616434 SGTC_305 1682-2595 20.8 µM 1.45818966020749 0.0506210040549289 no 245 0.0723941365111326 461 226033 SGTC_3043 9092303 49.47 µM 1.45794503314619 0.0506497313638094 no 246 0.0724278472392323 404 25236084 SGTC_1988 st071872 53.4 µM 1.45532035919545 0.0509587725975664 no 247 0.0727902964445018 394 16414116 SGTC_418 lividomycin a 100 µM 1.45312618936312 0.0512182745553092 no 248 0.0730943604033286 456 72394 An antibiotic. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.45099131498286 0.0514717718236901 no 249 0.0733911393139944 530 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2551 apiole 73.87 µM 1.4505038869632 0.0515297892304567 no 250 0.0734590280279061 292 10659 A possible DNA adduct former. SGTC_1755 st041960 45.185 µM 1.44723497299174 0.0519202252568113 no 251 0.0739155622819965 434 2257073 SGTC_1922 5578187 25 µM 1.44417196448194 0.0522881979170609 no 252 0.07434530449241 444 1350412 SGTC_3008 9078912 71.4286 µM 1.44402636863569 0.0523057404116744 no 253 0.0743657790878982 419 16648731 SGTC_246 cycloheximide 667 µM 1.44168983647231 0.0525879033488245 no 254 0.0746949460443623 381 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1505 k297-0037 20.6 µM 1.44135742695426 0.0526281435664804 no 255 0.0747418655730283 482 4089396 SGTC_210 3551-0445 56.827 µM 1.43947846258109 0.0528560634069166 no 256 0.0750075039067097 467 2865180 YOR207C RET1 SGTC_2257 7960413 200 µM 1.43598855016341 0.0532814696411027 no 257 0.0755027996821695 525 2974689 YIL048W NEO1 SGTC_1938 st074717 56.4 µM 1.43370150876465 0.0535617196351448 no 258 0.0758287307347646 391 17250979 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.43323077620801 0.0536195470307816 no 259 0.075895948595579 451 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3075 9116269 49.47 µM 1.43145004355253 0.0538387496291025 no 260 0.0761506373537947 456 17015205 YNL244C SUI1 SGTC_1405 3909-7894 12 µM 1.42845054767307 0.0542095817794506 no 261 0.0765811094255681 449 7104060 SGTC_2356 9061756 188.97 µM 1.42610581880243 0.0545008692758276 no 262 0.0769188997132237 422 20104043 SGTC_2462 5162487 171.77 µM 1.42421501810891 0.0547366653767618 no 263 0.0771921193977829 457 2259986 SGTC_1188 1403-0014 4.57 µM 1.42405081109555 0.0547571811452765 no 264 0.0772158819783215 536 9614867 SGTC_2452 5863136 48.41 µM 1.42099631336832 0.0551399146247778 no 265 0.0776589156033532 458 2184096 SGTC_3324 9138759 60.749 µM 1.42041799427634 0.0552126163142369 no 266 0.0777430136088726 459 45595710 SGTC_553 k007-0256 45.7 µM 1.41753925082954 0.055575636224045 no 267 0.0781626635229799 487 6287000 SGTC_46 0329-0187a 2.197 µM 1.41183223810853 0.0563008789538223 no 268 0.0789996818341873 581 46494817 SGTC_1687 st020778 55.3625 µM 1.41081241611703 0.0564312593867261 no 269 0.0791499662384288 641 4259299 SGTC_1389 3405-0187 19 µM 1.40741853001628 0.0568668693618644 no 270 0.079651659860028 436 799890 SGTC_11 0438-0307 1.3 µM 1.40586054202181 0.0570677240864723 no 271 0.0798827700695627 448 4011476 SGTC_176 1486-1328 72.834 µM 1.40581479306459 0.0570736304396622 no 272 0.0798895640751461 513 22310231 SGTC_819 1013-0258 27.7 µM 1.39773054894563 0.0581249124180665 no 273 0.0810969984785868 492 5753198 SGTC_2247 cerulenin 830 nM 1.39343214550029 0.0586900437060264 no 274 0.0817445753383918 486 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1217 1183-1422 255 µM 1.39122238418067 0.0589822452426748 no 275 0.0820790007399945 493 2849664 SGTC_1272 0839-0021 27 µM 1.38903886110944 0.059272097115518 no 276 0.0824104666660128 500 5027250 SGTC_2976 9009005 19.48 µM 1.38892005747987 0.0592878996904387 no 277 0.0824285303128504 476 2993148 SGTC_1822 st052468 42 µM 1.38854777455692 0.0593374400179702 no 278 0.0824851538436979 448 2873678 SGTC_511 blebbistatin 171 µM 1.38788983417433 0.0594250726326732 no 279 0.0825852969356153 469 3476986 A myosin inhibitor. SGTC_2757 clomiphene 4.22 µM 1.38661988369834 0.0595945071734459 no 280 0.0827788509641077 563 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2415 st077333 57.7 µM 1.38439752413124 0.0598919211346056 no 281 0.0831183833210917 570 2766255 SGTC_1334 1486-0610 236 µM 1.38407928031492 0.0599346060683001 no 282 0.0831670902501562 503 3742339 SGTC_44 0929-0055 61.211 µM 1.3807456447034 0.060383168237239 no 283 0.0836785907400056 453 1379590 SGTC_1453 4237-0541 195 µM 1.38064664550589 0.0603965292768589 no 284 0.083693816858706 478 739892 SGTC_1100 amiodarone 5.07 µM 1.37922954355573 0.060588036583323 no 285 0.0839119959303319 525 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2689 tacrolimus 100 µM 1.37821423972927 0.0607255367041534 no 286 0.0840685760242588 494 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_215 1287-0124 461.5 µM 1.37208366150537 0.0615609781817757 no 287 0.0850186975472397 396 5560863 SGTC_1346 1488-2224 62.4 µM 1.36924698101379 0.0619505704142903 no 288 0.0854610424304155 516 3722427 SGTC_425 3825-7017 13.1 µM 1.36900261811173 0.0619842212452854 no 289 0.0854992282615637 540 3397440 SGTC_682 0kpi-0099 17 µM 1.3683972854805 0.0620676420817624 no 290 0.0855938767409373 548 1714895 YML126C ERG13 SGTC_217 ketoconazole 989 nM 1.36776541660821 0.0621548132903576 no 291 0.085692758035098 499 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1150 3909-7983 10.9 µM 1.36571724549197 0.0624380310188455 no 292 0.0860138646562271 536 23965914 SGTC_2166 5933061 31.504 µM 1.36289191964509 0.0628303625912657 no 293 0.0864582878453845 487 2877375 SGTC_3081 9117243 49.47 µM 1.36171957773979 0.0629937196137975 no 294 0.0866432001521124 468 45595589 SGTC_2103 5378138 10 µM 1.35825815666763 0.0634779734232434 no 295 0.0871908913002029 568 244142 SGTC_3164 9100705 49.47 µM 1.3577637571731 0.0635473758871176 no 296 0.0872693292983032 429 17174235 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.35730616618015 0.0636116638778605 no 297 0.0873419744494179 547 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1177 0983-0204 23.6 µM 1.35709170831998 0.0636418109573556 no 298 0.0873760363765369 544 766818 SGTC_2999 9069765 71.4286 µM 1.35588765435465 0.0638112754222881 no 299 0.0875674580743544 537 2097066 SGTC_1620 st003704 16.5 µM 1.34937537880602 0.0647339349591483 no 300 0.088608212505504 504 2834414 SGTC_2385 9074692 200 µM 1.34909986981678 0.0647731963118252 no 301 0.08865244504221 515 17046906 SGTC_1680 diphenhydramine 100 µM 1.34534289281337 0.0653104306081854 no 302 0.0892572639852487 503 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2174 5790901 200 µM 1.34324419310032 0.0656120384045535 no 303 0.0895964580132978 500 786020 SGTC_2473 5854593 8.94 µM 1.34083543962838 0.0659595343743864 no 304 0.089986943533022 480 2872951 SGTC_2581 avocatin a 64 µM 1.33822012160342 0.0663384431078345 no 305 0.0904123458462084 563 6710728 A skin care supplement. SGTC_150 3970-0969 77.2 µM 1.33769465368242 0.0664147761450879 no 306 0.0904979972516737 609 6615640 SGTC_817 1391-0715 46 µM 1.33051479468066 0.0674645965468405 no 307 0.0916743575509744 488 1353946 SGTC_984 1492-0255 2.91 µM 1.32670527725028 0.0680267978079896 no 308 0.0923030972997044 487 1585198 SGTC_1206 3978-0017 132 µM 1.3260749961288 0.068120161213448 no 309 0.092407428663719 495 3873677 SGTC_2046 4110841 106 µM 1.32517011021996 0.0682543746715321 no 310 0.0925573682993644 522 44119630 YMR134W ERG29 SGTC_1025 k007-0731 70 µM 1.32253471483503 0.068646421569136 no 311 0.0929950787326075 493 6256118 SGTC_2313 7726885 200 µM 1.32186515978547 0.0687463021085551 no 312 0.0931065278934453 529 726423 SGTC_873 0591-4978 488 µM 1.31683138697707 0.0695008043570897 no 313 0.0939475747374678 585 3305145 SGTC_3125 9127534 49.47 µM 1.31660934231087 0.0695342324580638 no 314 0.0939848028343866 421 1639235 SGTC_1432 4049-0298 68.4 µM 1.31553068161457 0.0696967974909239 no 315 0.0941658064159366 508 741646 SGTC_64 000l-0018 272.079 µM 1.31388976918139 0.0699446603959118 no 316 0.0944416510502149 656 6811119 SGTC_1251 0490-5699 265 µM 1.30791068984224 0.0708535527164606 no 317 0.0954518016521436 601 3883818 SGTC_1983 st071813 46.9 µM 1.30670007127886 0.0710386810653803 no 318 0.0956572972369227 541 11838595 SGTC_2678 equilin 100 µM 1.30445060704169 0.0713836563079786 no 319 0.0960399949751059 553 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1739 st037196 92.5 µM 1.30401489068317 0.0714506256710071 no 320 0.0961142526708377 569 612214 SGTC_973 1325-0077 65.9 µM 1.30367044726547 0.0715036005496079 no 321 0.0961729848897142 586 2835149 SGTC_2857 9024691 58.44 µM 1.29901536540933 0.0722225045378141 no 322 0.0969693280406868 508 16478292 SGTC_2837 9008476 45.46 µM 1.29830582501498 0.0723325666944457 no 323 0.0970911327768097 569 2992805 SGTC_1401 3807-4679 7.6 µM 1.2980652577033 0.0723699120630833 no 324 0.0971324557481103 508 3291456 SGTC_284 0988-0104 32.6 µM 1.29750201094283 0.0724574075726353 no 325 0.0972292568253642 576 4666532 SGTC_1001 4048-4355 44.4 µM 1.29556954836068 0.0727582149713037 no 326 0.0975619130095457 534 21824233 SGTC_212 3807-4682 38.772 µM 1.29475341815606 0.0728855407312551 no 327 0.0977026529450767 713 3125501 YBL034C STU1 SGTC_1012 4112-3522 18 µM 1.29472261099841 0.0728903503432606 no 328 0.0977079684885419 542 3112398 SGTC_1688 st021091 57.6 µM 1.29465224410861 0.0729013369300379 no 329 0.0977201105616349 526 3656366 SGTC_945 3381-0768 11.3 µM 1.29464943397724 0.0729017757103288 no 330 0.0977205954834069 574 1126236 YIL048W NEO1 SGTC_1674 st016616 23.6 µM 1.29364979575394 0.073057989798404 no 331 0.0978932069686347 538 625830 SGTC_3201 9113999 49.47 µM 1.28826597926699 0.0739037306277227 no 332 0.0988266957303317 544 16649224 SGTC_2196 6573537 42.6665 µM 1.2857067680106 0.074308369974083 no 333 0.0992727091631404 523 2903087 SGTC_2090 5301565 104.445 µM 1.2836969524803 0.0746273281263031 no 334 0.0996240055809561 621 2056344 SGTC_367 0335-0881 7.1 µM 1.28310979414525 0.0747207072187374 no 335 0.0997268064581771 588 23828853 SGTC_2685 mycophenolic acid 18.85 µM 1.27943035723981 0.075307899901077 no 336 0.100372774692658 508 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2016 5121758 140 µM 1.2793729804554 0.0753170843012347 no 337 0.100382871981138 611 2795203 SGTC_21 0849-0113 22.993 µM 1.27365197101409 0.0762371497111012 no 338 0.101393392476924 580 1560156 SGTC_314 1671-0008 2.74 µM 1.26979845678871 0.0768616852034531 no 339 0.102078215288557 620 3913060 SGTC_228 caffeine 993.056 µM 1.26962983790355 0.0768891016680347 no 340 0.102108257862601 512 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_658 3253-0951 102 µM 1.2681982931352 0.0771221622013935 no 341 0.102363573216702 686 1184878 SGTC_2829 7992743 58.44 µM 1.26712894865861 0.0772966052254661 no 342 0.102554593013122 580 16462845 SGTC_2955 9076254 12.21 µM 1.26338656276399 0.0779094641718684 no 343 0.103225145412918 531 16459619 SGTC_3259 9138485 49.47 µM 1.26283671002369 0.0779998187393543 no 344 0.103323934433294 627 17646153 SGTC_2826 7992541 19.48 µM 1.26015521350386 0.0784415953570486 no 345 0.103806687818573 558 2985066 SGTC_2709 st078560 56 µM 1.25936065875176 0.0785728619173087 no 346 0.10395004629921 565 17250903 SGTC_502 l-744,832 89.3 µM 1.25875731764212 0.0786726496796881 no 347 0.104059000697698 582 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_892 0929-0076 29 µM 1.25823508715426 0.07875909991524 no 348 0.104153374561259 626 5751038 SGTC_2311 7694451 200 µM 1.25417278578054 0.0794340342264999 no 349 0.104889604607031 586 2163142 SGTC_2315 7733312 200 µM 1.25375743911841 0.0795032882492621 no 350 0.104965091627053 524 726316 SGTC_2387 9077560 195.08 µM 1.24942551317362 0.0802283100030347 no 351 0.10575474083889 581 5303272 SGTC_2988 9073640 71.4286 µM 1.24918695264904 0.0802683818771484 no 352 0.105798351493238 538 9102229 SGTC_2348 9022543 33.42 µM 1.24855662113341 0.0803743337235457 no 353 0.105913643373522 593 3162678 YDL140C RPO21 SGTC_863 0466-0191 129 µM 1.24837873081356 0.0804042542555558 no 354 0.105946197133577 633 765160 YPR165W RHO1 SGTC_2850 9015429 58.44 µM 1.24795194657878 0.0804760721912607 no 355 0.106024327726526 541 6457570 SGTC_2149 5554786 194.827 µM 1.24620768745736 0.0807700945766702 no 356 0.106344078760579 620 745063 YPR165W RHO1 SGTC_2612 dictamnine 15.46 µM 1.24491134829607 0.0809891378876119 no 357 0.106582169483629 574 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1872 amphotericin b 148 nM 1.24271195301522 0.0813617964454121 no 358 0.106986998823444 588 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2899 9053889 58.44 µM 1.24176479170575 0.081522678318739 no 359 0.107161678314713 553 6470052 SGTC_1474 0330-0125 5.35 µM 1.23598959826259 0.0825088293079008 no 360 0.108231215064284 597 X1474 SGTC_495 decylubiquinone 155 µM 1.23537043414452 0.0826150862460809 no 361 0.108346335551606 578 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_142 0335-0849 62.6745 µM 1.23531319871273 0.0826249138184993 no 362 0.108356981718472 716 3889043 YPR107C YTH1 SGTC_3283 9109332 35.8195 µM 1.23077958350825 0.0834061534583068 no 363 0.109202656756269 497 17027281 SGTC_2226 7298446 200 µM 1.23035288483091 0.0834799677542037 no 364 0.109282494225446 533 3283010 SGTC_2602 kawain 100 µM 1.22462605538986 0.0844754041592847 no 365 0.110358073106935 666 5369129 SGTC_466 geldanamycin 89.2 µM 1.22328677983159 0.084709476402557 no 366 0.110610699317209 462 5288382 HSP90 inhibitor. SGTC_2935 9038016 29.96 µM 1.21884960724162 0.0854884599050852 no 367 0.111450639561435 634 6463195 SGTC_2657 nystatin 74.44 µM 1.21463989317431 0.0862324588408556 no 368 0.112251733274138 631 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1555 citronellol 128 µM 1.21352569872272 0.0864301828662266 no 369 0.112464447570026 567 8842 A terpine precursor. SGTC_693 4161-2696 114 µM 1.20430805756902 0.0880789573439508 no 370 0.114235266755292 559 805759 SGTC_1488 4013-0813 75.9 µM 1.20227185347885 0.088446318243493 no 371 0.114629109143384 557 2910057 SGTC_449 xestospongin c 11.1929 µM 1.19255530870946 0.0902150569315451 no 372 0.116521788757177 648 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_787 4152-0075 138 µM 1.19251699025492 0.0902220838153691 no 373 0.116529296402328 610 9566539 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.19142590796519 0.0904223384177526 no 374 0.116743213581924 658 442882 SGTC_1159 4092-0538 61.2 µM 1.18863264917041 0.0909365100838669 no 375 0.117292127142455 672 717301 SGTC_1176 0848-0131 83.3 µM 1.18808219881554 0.0910380900695705 no 376 0.117400513427429 695 6769040 SGTC_99 0109-0120 622.8 µM 1.18310204147434 0.0919609551861465 no 377 0.118384354441016 581 759414 SGTC_2246 7293507 91.5585 µM 1.17980443759794 0.0925758299985257 no 378 0.119039002091823 659 887656 SGTC_1092 toremifene 6.32 µM 1.17586828945472 0.0933137437567899 no 379 0.119823756146596 683 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1844 rapamycin 4 nM 1.17532358645571 0.0934162011207855 no 380 0.119932640817505 751 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2915 7971052 15.16 µM 1.17302150219929 0.0938501356148677 no 381 0.120393591546385 469 5741558 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.17205670406026 0.0940324383189162 no 382 0.120587145519471 727 551469 SGTC_2934 9036370 36.88 µM 1.1704384258164 0.0943388053543185 no 383 0.120912289834102 677 6462800 SGTC_2645 abamectin 100 µM 1.16902230832116 0.0946075033910938 no 384 0.121197321755649 625 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2605 digitonin 300 nM 1.16876797952782 0.094655820135141 no 385 0.12124856231693 736 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1086 cerivastatin 2.18 µM 1.16561588075486 0.0952561582233094 no 386 0.1218848920664 618 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_184 1494-0393 24.714 µM 1.16130146568483 0.0960824054291101 no 387 0.122759661840048 678 3090647 SGTC_1165 k072-0275 30.3 µM 1.15970933826401 0.0963886386646842 no 388 0.123083583439924 635 6153523 YGL055W OLE1 SGTC_2045 5106652 78.05 µM 1.15900319177409 0.0965246897757308 no 389 0.123227442016244 640 673349 SGTC_1805 st050013 60.3 µM 1.15592131205027 0.0971201179263511 no 390 0.123856672210707 619 4037144 SGTC_3114 9122766 49.47 µM 1.15465840232706 0.0973648928719824 no 391 0.124115170171089 607 17176985 SGTC_889 0919-1524 82.7 µM 1.15414652363274 0.0974642330883519 no 392 0.124220051196768 622 3905452 SGTC_765 1319-0117 244 µM 1.15368989939168 0.0975529128020305 no 393 0.124313663205465 619 3487746 YGL099W LSG1 SGTC_2401 5128683 200 µM 1.15002291146448 0.0982672147445857 no 394 0.125067217397803 607 708373 SGTC_3195 9113082 49.47 µM 1.14930271146192 0.0984079532879574 no 395 0.125215590214564 642 17018038 SGTC_3063 1327-0034 4 µM 1.14785375780684 0.0986915489811347 no 396 0.125514470309274 639 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2847 9005661 71.43 µM 1.14633254253232 0.0989899312163333 no 397 0.125828791375296 530 2991449 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.14393407486696 0.0994617237655763 no 398 0.126325489145922 646 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2093 5331342 194.4 µM 1.14392940935773 0.0994626430972474 no 399 0.126326456654044 692 33839 SGTC_1659 st012954 42.1 µM 1.14142103795057 0.099957813722267 no 400 0.126847377026102 656 24207262 SGTC_1767 st044992 70.3 µM 1.13950268461925 0.100337723661426 no 401 0.127246774597953 655 9600693 SGTC_1325 1431-0015 227 µM 1.13902049688138 0.1004333814424 no 402 0.127347302620453 636 1103340 SGTC_383 2324-0395 7.37 µM 1.1377658931133 0.100682585105492 no 403 0.12760912518298 675 3146421 SGTC_1365 1672-3266 55.4 µM 1.13731822958477 0.10077161420717 no 404 0.127702638363681 718 6415873 SGTC_2546 rhodinyl acetate 100 µM 1.13618716265738 0.100996810927527 no 405 0.12793912100005 702 6708682 SGTC_674 0498-0004 451 µM 1.13547814518438 0.101138164049965 no 406 0.128087516904872 643 4231473 SGTC_2603 homopterocarpin 100 µM 1.13458592645193 0.101316245855766 no 407 0.12827442629104 686 101795 A weak amylase inhibitor. SGTC_717 1532-0246 73.2 µM 1.13420813792971 0.101391719110264 no 408 0.128353625612329 682 9561992 SGTC_2407 paclitaxel 400 µM 1.13266572808253 0.101700281241184 no 409 0.128677327555083 707 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1621 st003705 32.4 µM 1.12353026559992 0.103541872693515 no 410 0.130606177005709 748 24207032 SGTC_1139 k015-0024 46.9 µM 1.12318036856647 0.103612885521158 no 411 0.130680449211807 694 2766652 SGTC_965 1291-5240 308 µM 1.12030473428305 0.10419784464788 no 412 0.131291962649084 715 2834598 SGTC_165 k038-0023 64.381 µM 1.11619630504315 0.105037725642189 no 413 0.132169057889959 687 46368543 SGTC_2442 5158906 48.48 µM 1.11594970507856 0.105088293198525 no 414 0.132221831931812 707 1893835 SGTC_1484 3473-2379 286 µM 1.11261182325672 0.105774490065856 no 415 0.132937590180163 796 671917 SGTC_2981 9013952 38.96 µM 1.11151133602691 0.106001435052634 no 416 0.133174156667115 635 2996344 SGTC_185 k048-0037 25.491 µM 1.10974013705188 0.106367434240337 no 417 0.133555510911046 728 6827589 SGTC_705 1124-0212 310 µM 1.10967939474926 0.106380002147205 no 418 0.133568602552282 709 9554485 SGTC_1200 1643-0193 18.4 µM 1.10832323682841 0.106660877743014 no 419 0.133861121793872 730 5403974 SGTC_2859 9028643 45.46 µM 1.10761388132194 0.106808006292212 no 420 0.134014302931631 659 17151580 SGTC_3277 9138724 49.47 µM 1.10757952226754 0.106815136474652 no 421 0.134021725623791 592 15943418 SGTC_2105 5350118 200 µM 1.10756122571196 0.106818933511463 no 422 0.134025678400209 711 2133313 SGTC_1760 st045453 10.4495 µM 1.10592063869817 0.107159796275797 no 423 0.134380435432303 734 3323419 YIL048W NEO1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.1043954968509 0.107477376014698 no 424 0.134710806678359 676 115019 SGTC_2549 cedrol 20.94 µM 1.10299494861554 0.107769608630897 no 425 0.135014679403951 644 6708665 A sedative which affects the nervous system. SGTC_3136 9095672 49.47 µM 1.10011814977705 0.108371663976454 no 426 0.135640323432818 618 17217380 SGTC_3032 9089427 49.47 µM 1.09955323939355 0.108490171942373 no 427 0.135763412633007 669 17173707 SGTC_1780 st038448 24.544 µM 1.09951669234427 0.108497842061026 no 428 0.135771378560226 702 728868 YDL195W SEC31 SGTC_1134 3477-0009 42.5 µM 1.0972246662582 0.108979648595484 no 429 0.136271596506766 756 3973534 SGTC_1998 st075797 76.8 µM 1.09513171777394 0.109420948698406 no 430 0.136729467421149 798 24208315 SGTC_2515 chrysin 20.77 µM 1.09475770075789 0.109499945515741 no 431 0.136811401155558 715 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_392 N-ethylmaleimide 8.33 µM 1.09342432621369 0.109781903248479 no 432 0.137103768829523 681 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1270 0831-1170 17.3 µM 1.09317107727605 0.109835514552503 no 433 0.137159346665216 773 6764716 SGTC_3002 9075603 71.4286 µM 1.09247968620732 0.10998197362672 no 434 0.137311157224483 727 20105405 SGTC_1553 gossypol 38.6 µM 1.09159439970199 0.110169710567633 no 435 0.137505709393632 611 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_718 1130-0073 349 µM 1.09071625380905 0.110356160229633 no 436 0.137698878160065 738 6740020 SGTC_2814 7977482 42.97 µM 1.08999446702095 0.110509580754145 no 437 0.137857790678587 778 6456762 SGTC_3015 9080845 49.47 µM 1.08924746399794 0.110668522098824 no 438 0.1380223866444 758 5296973 SGTC_1653 st012112 65 µM 1.08635407575371 0.111285700261405 no 439 0.138661185593034 679 720429 SGTC_408 cantharidin 100 µM 1.08634379348848 0.111287897919013 no 440 0.138663459285283 741 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1893 st059353 36.1 µM 1.08558295631887 0.111450600010759 no 441 0.1388317718258 708 3112488 SGTC_1887 st057648 70.8 µM 1.08429170672263 0.111727118245891 no 442 0.139117740616139 733 688672 SGTC_687 k029-0044 34.9 µM 1.0839267168446 0.111805368908595 no 443 0.139198646350044 768 5829338 SGTC_3299 9121982 43.1275 µM 1.08258772126668 0.112092773593653 no 444 0.139495729902784 727 17594604 YPL160W CDC60 SGTC_1567 st069303 68.4 µM 1.08194371537592 0.112231192239436 no 445 0.139638769257534 739 5581319 SGTC_2130 NSC 7 2.4545 µM 1.0812364800184 0.112383341726375 no 446 0.13979596729682 770 21448 SGTC_3158 9100007 49.47 µM 1.08014287199532 0.112618902669227 no 447 0.140039281593361 648 19297233 SGTC_564 3555-0129 330 µM 1.0771565034032 0.11326395606181 no 448 0.140705176835268 642 563260 SGTC_1492 4158-0558 28.5 µM 1.07613499479572 0.113485204975353 no 449 0.140933443443401 709 3967268 SGTC_1879 gemcitabine 100 µM 1.07532931983274 0.113659923667903 no 450 0.141113656900909 741 60750 A nucleoside analog which inhibits DNA replication. SGTC_346 4513-0042 7.16 µM 1.07347771016802 0.114062190331812 no 451 0.141528417158655 749 2827372 SGTC_964 1287-0107 19.4 µM 1.07239392873739 0.114298114477462 no 452 0.141771566874271 778 51516812 YPR165W RHO1 SGTC_794 k038-0031 316 µM 1.06980895345071 0.114862229875056 no 453 0.142352655674707 811 6624242 SGTC_1993 st073995 70.8 µM 1.06577018945319 0.115747563141304 no 454 0.143263769887826 754 3098394 SGTC_2836 9010338 19.48 µM 1.0626130022148 0.116443014148354 no 455 0.143978744075771 668 2994051 SGTC_1085 doxorubicin 7.67 µM 1.06158868820077 0.116669280963227 no 456 0.144211225606144 791 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3004 9076122 71.4286 µM 1.06134187339979 0.116723847931385 no 457 0.144267281284757 750 44782551 SGTC_2379 9035213 200 µM 1.06131680119385 0.116729392023931 no 458 0.144272976414537 803 646551 SGTC_2212 7123476 200 µM 1.05934676337513 0.11716560052662 no 459 0.144720942604844 656 1085715 SGTC_1411 3909-8223 150 µM 1.05932188325746 0.117171116891087 no 460 0.144726606069641 778 X1411 SGTC_2050 5263056 171 µM 1.0592436040022 0.117188473993921 no 461 0.144744425761502 812 763468 YGL055W OLE1 SGTC_352 k048-0007 5.11 µM 1.05917293432088 0.117204145366634 no 462 0.144760514459427 800 6811911 SGTC_647 0140-0236 81 µM 1.0584309487227 0.117368774191522 no 463 0.144929508005861 832 990837 SGTC_2996 9066192 71.4286 µM 1.05797108145359 0.117470889883093 no 464 0.14503431334076 716 6472854 SGTC_2195 6536160 144.242 µM 1.05702444018219 0.117681294024233 no 465 0.145250216707264 660 3834386 SGTC_2740 felodipine 17.08 µM 1.05435755854243 0.118275479202345 no 466 0.145859622822476 685 3333 L-type calcium channel blocker SGTC_111 0083-0039 52.457 µM 1.05377265638887 0.118406079398037 no 467 0.145993507580793 624 759313 SGTC_1310 1188-0297 994 nM 1.05250360835945 0.118689789912491 no 468 0.146284277944191 756 1588352 SGTC_987 1497-1013 404 µM 1.05232446022036 0.118729879225045 no 469 0.146325356526476 723 1676435 SGTC_1076 itraconazole 331 nM 1.05135697975871 0.118946544854679 no 470 0.146547333188617 777 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1142 3253-1408 9.78 µM 1.05027376835654 0.119189459373105 no 471 0.14679613096543 750 256655 SGTC_1754 st042065 16.137 µM 1.04991480182203 0.119270036260644 no 472 0.146878642791476 847 1126236 YIL048W NEO1 SGTC_3315 9136395 68.55 µM 1.04974032569199 0.119309214638473 no 473 0.146918758999861 813 16876844 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.049581304501 0.119344930541149 no 474 0.146955328151132 773 688669 SGTC_2536 dehydroabietamide 32.04 µM 1.04939788564573 0.119386135489128 no 475 0.146997515467925 799 3983547 SGTC_897 1000-0139 31.4 µM 1.04747274879999 0.119819222140065 no 476 0.147440797189294 749 6151020 SGTC_1268 0828-0275 2.46 µM 1.04691860790286 0.119944089003894 no 477 0.147568559431643 800 745337 SGTC_3176 9106582 49.47 µM 1.04377450339158 0.120654299830706 no 478 0.148294865268345 605 17018027 SGTC_1081 sertraline 6 µM 1.04310238848152 0.120806504835502 no 479 0.148450437307127 781 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3237 9133362 49.47 µM 1.0412703015045 0.121222079510711 no 480 0.148875058011714 758 43845137 SGTC_1867 st057372 64 µM 1.04030236607098 0.121442043026927 no 481 0.14909972264193 743 688837 SGTC_1060 3448-7350 82 µM 1.03860979123207 0.121827355025754 no 482 0.14949312512921 768 570178 SGTC_57 miconazole 162.5 nM 1.03729285115233 0.122127747880809 no 483 0.14979969822211 720 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_362 0310-0100 9.03 µM 1.03724145698627 0.122139481379067 no 484 0.149811670868228 722 790235 SGTC_2946 9065502 71.43 µM 1.03459331331391 0.12274513481816 no 485 0.150429439031201 602 16489101 SGTC_587 k089-0003 57 µM 1.03445272423495 0.122777347539806 no 486 0.150462283515673 640 9659696 SGTC_1889 st059080 5.18 µM 1.0343103648482 0.122809971927279 no 487 0.150495546447876 819 176925 Isolated from Daphnopsis sellowiana. SGTC_2034 5197015 53.07 µM 1.03394516842757 0.122893691501064 no 488 0.150580898688055 769 780676 SGTC_1377 2944-0135 198 µM 1.0286272225938 0.124117341567126 no 489 0.151827440342407 790 1894137 SGTC_435 c-PAF 6.7 µM 1.02851999611385 0.124142101554086 no 490 0.151852644850334 784 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1354 1498-1681 81 µM 1.0275596884995 0.124364003117666 no 491 0.152078497360206 826 5754243 SGTC_983 1491-0821 12.2 µM 1.02709324094704 0.124471886777842 no 492 0.152188280528266 797 46495113 SGTC_2944 9067346 25.62 µM 1.02649211361713 0.124611016716264 no 493 0.15232983953545 745 6473075 SGTC_2941 9056145 11.23 µM 1.02517219605072 0.124916890779731 no 494 0.152640972459563 699 2119517 SGTC_299 1273-0059 1.44 µM 1.02466931410936 0.125033565135616 no 495 0.152759623366156 733 2848077 SGTC_2176 5809774 33.9695 µM 1.02203873576542 0.125645129797727 no 496 0.153381283636196 813 2870539 SGTC_230 MPP+ 141.667 µM 1.02130035752822 0.125817164658305 no 497 0.153556078546643 745 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3294 9122953 26.2835 µM 1.0170744023074 0.126804931434941 no 498 0.154559018219989 792 16459826 SGTC_151 3013-0144 2.285 µM 1.01630822090201 0.126984593838083 no 499 0.154741317515902 792 906558 YHR107C CDC12 SGTC_3181 9108277 49.47 µM 1.01326524137524 0.127699892999539 no 500 0.15546674262859 766 17097298 SGTC_1063 disulfiram 1.84 µM 1.0125082228172 0.127878276068017 no 501 0.155647558543633 759 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_891 0929-0073 133 µM 1.01152523666795 0.128110164195274 no 502 0.155882554326068 797 5603632 SGTC_1834 st055981 52.8 µM 1.00929456338166 0.128637466823938 no 503 0.156416693339088 807 471719 YDL150W RPC53 SGTC_535 2293-4129 48.2 µM 1.00899554653137 0.128708264891635 no 504 0.156488385006279 877 396118 YIL048W NEO1 SGTC_3280 9140961 49.47 µM 1.00770333984025 0.129014530854508 no 505 0.15679845058438 756 4901226 SGTC_3096 9117468 49.47 µM 1.00683383245106 0.129220897052549 no 506 0.157007316667694 681 41316311 SGTC_1870 st057514 26.5 µM 1.00244314303737 0.130266464104691 no 507 0.158064806995207 779 5393161 SGTC_2006 4011487 200 µM 1.00093190650867 0.130627689346339 no 508 0.158429864908062 828 45595294 SGTC_324 1315-0088 19.6 µM 1.00074531061793 0.13067233865567 no 509 0.158474977787145 721 6787421 SGTC_3303 9125618 40.5795 µM 0.997761443022614 0.131387762366675 no 510 0.159197525458913 869 22695467 SGTC_1527 coumarin 137 µM 0.997239636487635 0.131513150023151 no 511 0.159324102950188 749 323 A hepatotoxic, DNA x-linker. SGTC_1106 tegaserod maleate 11.7 µM 0.996046968147881 0.131800052699906 no 512 0.159613662480857 832 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3064 1327-0027 10 µM 0.995718303809212 0.131879190481472 no 513 0.159693517069372 653 16000455 YPR107C YTH1 SGTC_458 nppb 133 µM 0.992478088371627 0.132661143707136 no 514 0.160482181522806 788 4549 A chloride channel blocker. SGTC_3257 9139206 32.98 µM 0.9913729046724 0.132928583936794 no 515 0.160751762876673 784 4910041 SGTC_995 3931-2021 34.6 µM 0.988200505808922 0.133698324695527 no 516 0.161527230255701 790 730143 SGTC_846 0335-0850 148 µM 0.987698373739424 0.133820440765505 no 517 0.161650195603505 804 6819598 SGTC_291 SEC14.278 35.5 µM 0.986960866395715 0.133999937911624 no 518 0.16183091176333 829 1068044 SGTC_1855 st056195 39.6 µM 0.985489215229215 0.134358607824094 no 519 0.162191913164863 786 4028379 SGTC_2592 piperlongumine 83.33 µM 0.985071789573132 0.134460462449162 no 520 0.162294404585252 754 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2924 9010168 62.78 µM 0.98478416727223 0.134530675035558 no 521 0.162365049637131 804 2993929 SGTC_1427 4048-4900 550 nM 0.983693802507624 0.134797076704467 no 522 0.162633043971863 838 24132586 SGTC_319 1348-1596 45.5 µM 0.983091614967848 0.134944360283403 no 523 0.162781175381262 852 5380505 SGTC_75 0159-0059 199.013 µM 0.982901794634328 0.134990809587262 no 524 0.162827887247043 789 5377270 SGTC_135 0933-0004 26.348 µM 0.981105704403999 0.135430858186078 no 525 0.163270308844194 770 21230617 YGL099W LSG1 SGTC_2038 4100038 30.985 µM 0.98008412751238 0.135681586337305 no 526 0.163522296715142 824 3596803 SGTC_2111 5486399 200 µM 0.979827415192563 0.135744641836886 no 527 0.163585658498247 861 689674 SGTC_465 cgp-37157 41 µM 0.978681023058657 0.136026471720365 no 528 0.163868805744366 714 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2871 9038510 12.99 µM 0.975337860419789 0.136850643456589 no 529 0.164696348071713 846 4945164 SGTC_1415 3966-0071 78.1 µM 0.973767471723612 0.137238958659236 no 530 0.165086003743792 832 2893185 SGTC_778 3456-2434 196 µM 0.97364252572445 0.137269886758647 no 531 0.165117031817301 929 5539063 SGTC_450 aminopyrene 156 nM 0.971492317333609 0.137802877467477 no 532 0.165651588516644 832 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1633 st005664 67.9 µM 0.971034385258169 0.137916571181284 no 533 0.165765577987559 837 2063822 SGTC_3213 9129884 49.47 µM 0.96952586203275 0.138291554356814 no 534 0.166141441529414 745 17190742 SGTC_1340 1486-1359 257 µM 0.968596000744686 0.138523041797347 no 535 0.166373399766437 833 4309068 SGTC_2783 7738165 71.43 µM 0.968125613009391 0.138640244561176 no 536 0.166490819791419 712 17201110 SGTC_1618 st003135 44.5 µM 0.967098536418388 0.138896387783047 no 537 0.166747388547859 829 1270615 SGTC_1059 3448-6867 171 µM 0.966717988657342 0.138991374571493 no 538 0.166842515978084 857 3934407 SGTC_464 bw-b 70c 158 µM 0.964142518970964 0.139635388133525 no 539 0.167487239037579 871 5353454 SGTC_360 0957-0399 1.01 µM 0.962824728285676 0.139965694082616 no 540 0.16781774443994 864 6752301 YPR165W RHO1 SGTC_586 0957-0265 8.15 µM 0.960759637351576 0.140484379042153 no 541 0.168336518728785 770 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3217 9129673 49.47 µM 0.960418299851419 0.140570237643666 no 542 0.168422365811663 798 17248312 SGTC_2134 5324836 1.464 µM 0.959533862270435 0.140792871044609 no 543 0.168644934633946 786 699272 SGTC_844 0330-0132 15.3 µM 0.959050361547013 0.140914680453534 no 544 0.168766687536158 893 2828079 SGTC_943 3253-1379 105 µM 0.959037066873542 0.14091803081966 no 545 0.168770036136693 836 668464 SGTC_2280 7785178 200 µM 0.954761798929584 0.14199823650469 no 546 0.169849084942386 831 2954328 SGTC_2302 7771753 200 µM 0.954121773318934 0.142160428966118 no 547 0.170011002952372 845 2203047 SGTC_2555 cholic acid 100 µM 0.953763468198757 0.142251283787305 no 548 0.170101692591554 840 6708657 Influences liver metabolism. SGTC_325 2810-4341 181 µM 0.953406899843367 0.142341737216977 no 549 0.170191973415316 866 774970 SGTC_2248 tofa 1.1 µM 0.94870364060197 0.143538490825166 no 550 0.171385680950158 829 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_420 mitomycin C 81.9 mM 0.945536233543261 0.144348260308124 no 551 0.172192590762851 842 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3116 9124943 49.47 µM 0.944983284897293 0.144489940504307 no 552 0.172333704835901 814 41905195 YPL160W CDC60 SGTC_2270 7924575 90.91 µM 0.944298471611795 0.144665537781355 no 553 0.172508573376569 879 1262135 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.943378130167355 0.144901754628047 no 554 0.172743762702084 932 1273210 SGTC_192 3455-0609 60.9 µM 0.941454744985327 0.145396252916388 no 555 0.173235935124343 857 3769639 SGTC_2747 doxorubicin 7.63 µM 0.941073842751075 0.145494316580168 no 556 0.173333509505404 684 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1648 st011736 69.8 µM 0.940797055152369 0.145565603724993 no 557 0.173404435154127 844 2855514 SGTC_113 0099-0221 2.5 µM 0.940125736082951 0.145738600711142 no 558 0.173576534548393 834 89219 SGTC_2771 fluoxetine 41.05 µM 0.939417385255655 0.145921290468276 no 559 0.173758245211874 828 3386 A selective serotonin reuptake inhibitor. SGTC_1840 st055363 71 µM 0.938737126854419 0.146096879744846 no 560 0.173932863284345 807 676033 SGTC_1410 3909-8106 77.9 µM 0.937296152372539 0.146469294746301 no 561 0.174303120793974 851 1039210 SGTC_1774 st048371 48.465 µM 0.93591005786054 0.146828127021056 no 562 0.174659749120258 873 4242727 SGTC_296 1222-0039 74.9 µM 0.935877119352592 0.146836661312328 no 563 0.174668229502206 823 5984176 SGTC_1917 st066507 28.5 µM 0.934497195015835 0.147194495510181 no 564 0.175023741108166 875 3156428 SGTC_3093 9117344 49.47 µM 0.934001874407252 0.147323081712621 no 565 0.175151463055669 826 24824913 SGTC_2184 6075246 200 µM 0.93249649080402 0.147714344223987 no 566 0.175539999691765 865 2267320 SGTC_85 0868-0259 160.055 µM 0.925796156365785 0.149464256178137 no 567 0.177275962525893 829 83173 SGTC_3123 9126162 49.47 µM 0.923665359529642 0.150023639899254 no 568 0.177830286464319 872 25239884 SGTC_1306 1185-0270 9.02 µM 0.923435271526285 0.150084126744862 no 569 0.177890208884755 916 1548076 SGTC_766 1391-0721 126 µM 0.919992813273541 0.150991040982744 no 570 0.178788257413754 903 1020919 YIL115C NUP159 SGTC_797 k781-0471 270 µM 0.918822000834634 0.151300320481411 no 571 0.17909434143605 918 23738129 SGTC_1382 3002-2117 298 µM 0.917820883783009 0.151565107526603 no 572 0.179356323496989 955 1497314 SGTC_2171 5739187 198.077 µM 0.91707082196674 0.151763694315935 no 573 0.179552764793549 844 2262761 SGTC_2870 9038528 12.99 µM 0.915430491525716 0.152198591416766 no 574 0.179982838586191 780 6463316 SGTC_1223 0764-0573 147 µM 0.913209892666637 0.152788650835394 no 575 0.180566081009932 925 1609797 SGTC_24 0417-1663 219 µM 0.912577042942146 0.152957089632738 no 576 0.180732516404603 886 4329390 SGTC_2152 5568786 200 µM 0.910955962770711 0.153389116475541 no 577 0.181159288590764 888 5399883 SGTC_382 3229-0966 23.2 µM 0.910766389109494 0.153439691647201 no 578 0.181209237720796 931 5722370 SGTC_1030 k029-0042 36.7 µM 0.910090897874536 0.153619991518705 no 579 0.181387287200544 916 6080581 SGTC_1718 roemerine 11.9335 µM 0.903997751737012 0.155252691637179 no 580 0.18299829677034 902 235224 An aporphine alkaloid with mutagenic activity. SGTC_2928 9011484 9.79 µM 0.903900975235398 0.155278715626323 no 581 0.183023956002978 847 2994751 SGTC_3061 glucosamine 200 µM 0.902389161788948 0.155685628352882 no 582 0.183425088227132 901 91431 and experimental redox chemotherapeutic SGTC_2479 5617353 43.85 µM 0.90152838751044 0.155917624288005 no 583 0.183653723709095 883 2731746 SGTC_2188 6126565 140.678 µM 0.900953976113006 0.156072566397615 no 584 0.183806395351972 878 874518 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.900301944934292 0.1562485686379 no 585 0.18397979317033 915 229346 A bile salt which induces apoptosis. SGTC_996 3970-0799 1.8 µM 0.900109876169875 0.1563004385224 no 586 0.184030890364225 1093 6615648 YGL040C HEM2 SGTC_1796 st049173 110.4 µM 0.899073724965245 0.156580456026429 no 587 0.184306696197916 868 94134 SGTC_3117 9124945 49.47 µM 0.899068113843528 0.156581973317841 no 588 0.184308190482954 821 17592065 SGTC_2564 betulinic acid 100 µM 0.897306858145851 0.157058709059648 no 589 0.1847775989682 964 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1738 st035555 74 µM 0.894148005010119 0.157916134867884 no 590 0.185621353723215 907 5331140 SGTC_2960 9079389 5.97 µM 0.893718432749302 0.15803297312243 no 591 0.185736280262642 916 16457355 SGTC_2260 7964312 200 µM 0.893172882436126 0.158181437729069 no 592 0.185882298850385 857 231951 SGTC_260 nsc-65238 3.989 µM 0.890303430699133 0.158963829082612 no 593 0.186651489751554 901 3246252 SGTC_2606 farnesol 9.78 µM 0.890119415844127 0.159014089376553 no 594 0.186700884285318 906 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1740 st038286 13.222 µM 0.888878345344188 0.159353336986018 no 595 0.187034232261093 896 716786 SGTC_251 melphalan 456.522 µM 0.88881158465786 0.159371599495032 no 596 0.187052174419467 1014 460612 A DNA alkylator. SGTC_2449 5812982 45.77 µM 0.888746079160432 0.159389519976724 no 597 0.187069780276455 876 776185 SGTC_619 1652-1634 108 µM 0.887815603284982 0.15964421475432 no 598 0.187319974167651 863 5400454 SGTC_2879 9041815 71.43 µM 0.887319592240672 0.159780094290232 no 599 0.187453430127888 848 4942971 SGTC_369 0957-0393 4.5 µM 0.885215107966672 0.160357447633608 no 600 0.188020312732018 887 6997992 SGTC_1079 idarubicin 2.36 µM 0.884882334970422 0.160448866697904 no 601 0.188110048228093 909 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1028 k015-0029 4.8 µM 0.884291372224659 0.160611299306463 no 602 0.188269472255625 931 4588309 SGTC_223 busulfan 5 mM 0.884161113746721 0.160647116722551 no 603 0.188304623295808 853 2478 A DNA alkylator. SGTC_3346 9158254 43.5805 µM 0.880272287656281 0.161718836951876 no 604 0.18935591069695 916 17639500 SGTC_2435 5706476 10.6 µM 0.880251903918635 0.161724466747279 no 605 0.189361430643608 978 5725375 SGTC_2121 5257820 149.641 µM 0.876508396158023 0.162760553791976 no 606 0.190376856985107 997 791256 SGTC_1316 1272-0050 65.9 µM 0.875228190006598 0.163115863655081 no 607 0.190724878818426 932 7340392 SGTC_1290 0986-0249 10.2 µM 0.873524286860542 0.163589548248411 no 608 0.191188687156199 940 53329 SGTC_2778 tioconazole 65.09 nM 0.872759490410319 0.163802451578583 no 609 0.191397092052106 889 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_697 0508-1955 564 µM 0.871913241910132 0.164038238946748 no 610 0.191627854575326 985 6243113 SGTC_1661 st013063 9.66 µM 0.871582772786351 0.164130376196883 no 611 0.191718016066043 1009 721395 SGTC_1546 5-methoxyflavanone 78.7 µM 0.87078151833944 0.164353911226976 no 612 0.191936729172138 976 147795 SGTC_2682 pyrogallin 40.03 µM 0.869175042514995 0.164802682270214 no 613 0.192375698027607 1019 822798 An ATP competetive kinase inhibitor. SGTC_2588 indole-3-carbinol 100 µM 0.868557178205117 0.164975494588224 no 614 0.192544692528294 973 3712 Induces cell cycle arrest. SGTC_2369 9071472 200 µM 0.868351885126529 0.165032939584977 no 615 0.192600863125544 945 17296037 SGTC_2953 9074162 66.49 µM 0.867838570336281 0.165176631715486 no 616 0.19274135590351 902 16451992 SGTC_2795 7780010 54.55 µM 0.867523410533067 0.165264894461262 no 617 0.192827645249491 895 953673 SGTC_3345 9148410 3.559 µM 0.86676723332555 0.16547679171615 no 618 0.193034779410968 942 4903596 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.865883600390379 0.165724627407536 no 619 0.193276998668646 952 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2437 5741531 144.16 µM 0.865793852488914 0.165749812741184 no 620 0.193301610511938 1000 2262990 SGTC_250 brefeldin a 552.239 µM 0.864042721783501 0.166241715581764 no 621 0.193782211120016 862 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_916 4466-0038 42 nM 0.863957397342245 0.166265707781743 no 622 0.193805647144856 1044 5722064 YGL116W CDC20 SGTC_2012 4023501 200 µM 0.86336701391573 0.166431777720712 no 623 0.193967854820338 883 3477460 SGTC_1758 st042942 75.2445 µM 0.862610407582365 0.166644761290693 no 624 0.194175853095309 958 669317 SGTC_1162 k048-0130 20.1 µM 0.861401716856282 0.166985370731494 no 625 0.19450841540287 932 6797406 SGTC_55 0767-0285 6.563 µM 0.860227191930083 0.167316782049797 no 626 0.194831909127746 1003 3116166 SGTC_2431 5490079 200 µM 0.859492544595852 0.167524290096184 no 627 0.195034415738376 995 5722345 SGTC_2327 6189656 200 µM 0.856488116630409 0.168374643601599 no 628 0.195863921563267 957 5349088 SGTC_1677 st019204 53.9 µM 0.856018849558202 0.16850771208013 no 629 0.195993676621715 897 3945625 SGTC_245 methotrexate 289.6 µM 0.854590044290218 0.168913289787022 no 630 0.196389070525434 977 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2361 9034121 116 µM 0.852089406093226 0.169624623634837 no 631 0.197082235694336 949 6496917 SGTC_2820 7989630 71.43 µM 0.851793713252008 0.169708863560388 no 632 0.197164298138545 861 2984098 SGTC_183 3914-0051 30.55 µM 0.848168538150498 0.170743819991724 no 633 0.198172058040533 982 1596232 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.848136820997253 0.170752892756924 no 634 0.19818088877005 921 77254 SGTC_1994 st072947 40.9 µM 0.848120538506799 0.170757550520916 no 635 0.198185422253708 946 5286565 YDL195W SEC31 SGTC_908 3448-7491 47.7 µM 0.847707362390952 0.170875770759448 no 636 0.198300482556588 1015 1203031 SGTC_2766 oltipraz 83.91 µM 0.847631763425003 0.170897407220741 no 637 0.198321539539354 939 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_543 3844-1095 191 µM 0.844303963361678 0.17185156181344 no 638 0.199249785968012 983 4230703 SGTC_820 1582-0060 59.9 µM 0.843622866816927 0.172047265990591 no 639 0.1994400910356 956 3848840 SGTC_3132 9126706 49.47 µM 0.843345510166039 0.172127001540042 no 640 0.199517618550483 921 850858 SGTC_862 0452-0056 10.2 µM 0.842415614635887 0.172394503517254 no 641 0.199777677902459 964 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2532 xanthone 78.9 µM 0.842074164229634 0.172492794690985 no 642 0.199873220833263 890 7020 An insecticide. SGTC_1800 st050079 29.0735 µM 0.840062416660601 0.173072629181216 no 643 0.200436695594673 1036 3645560 SGTC_2617 dihydrotanshinone i 20.83 µM 0.839794711435568 0.173149881821847 no 644 0.200511749600954 1008 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1466 k213-0079 57.5 µM 0.839763449006277 0.173158904763165 no 645 0.200520515455855 988 3657981 SGTC_525 k781-2675 26.7 µM 0.839727882155949 0.173169170407724 no 646 0.200530488532323 1028 3651118 YDL195W SEC31 SGTC_2891 9063876 19.48 µM 0.838362325985214 0.173563603387789 no 647 0.200913620761766 937 6472478 SGTC_1619 st003326 88.7 µM 0.837793949895371 0.173727943893654 no 648 0.201073218627089 971 2849032 SGTC_722 3534-0461 190 µM 0.836279640446905 0.174166274982011 no 649 0.201498802031722 1017 658262 SGTC_937 3122-0005 46.7 µM 0.835325793737139 0.174442735366224 no 650 0.201767149145029 1026 759535 SGTC_2098 5376439 882.5 nM 0.834821087297047 0.174589130840395 no 651 0.201909225495369 1040 2844116 SGTC_1534 6-azauridine 81.6 µM 0.832865736780162 0.175157037418918 no 652 0.202460227666354 1073 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2643 anethole 100 µM 0.832739820590781 0.175193648279016 no 653 0.202495740628279 1030 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_704 1310-0270 142 µM 0.831406815989945 0.175581524683145 no 654 0.202871924939301 1037 5718033 SGTC_1625 st003711 30.1 µM 0.830720939398889 0.175781312278279 no 655 0.203065647220157 1003 24207034 YER133W GLC7 SGTC_1936 st074407 74.3 µM 0.829235604723313 0.176214465768606 no 656 0.203485550697389 1055 809813 SGTC_1331 1472-0049 76.2 µM 0.828387555982049 0.176462076536388 no 657 0.203725525817459 979 24051409 SGTC_1234 0326-0494 15.5 µM 0.82681785089668 0.176920974782368 no 658 0.204170155318773 1013 1547813 SGTC_1132 3456-3614 2.5 µM 0.826410783015912 0.177040102810796 no 659 0.204285554332198 1082 3125502 SGTC_1494 4358-1428 177 µM 0.82625112047605 0.177086841735332 no 660 0.204330827408224 1040 1564571 SGTC_2646 retinol 96.75 µM 0.825547471308294 0.177292917830035 no 661 0.204530421652556 996 445354 A vitamin A analog and teratogen. SGTC_2252 omeprazole 400 µM 0.825438079441216 0.177324968767586 no 662 0.204561461719488 924 4594 A proton pump inhibitor. SGTC_1727 st034309 9.9045 µM 0.824929629411656 0.177473988556353 no 663 0.204705771783487 1063 870305 SGTC_968 1309-0633 340 µM 0.823737785826198 0.177823611426773 no 664 0.205044282258016 1001 3761976 SGTC_3186 9110464 49.47 µM 0.82194817344421 0.178349402867065 no 665 0.205553196983021 986 17018021 SGTC_2069 5228469 200 µM 0.821436047671953 0.178500046457094 no 666 0.205698968835434 961 2835210 SGTC_193 1273-0060 1.558 µM 0.819304347697263 0.17912795424998 no 667 0.206306396334398 894 2847393 YHR072W ERG7 SGTC_1744 st037937 38.9 µM 0.819210264948254 0.179155698988592 no 668 0.206333229667934 1012 1016152 SGTC_2964 9083345 53.42 µM 0.818333381376338 0.179414419485076 no 669 0.206583425023099 969 17741579 SGTC_1642 st009582 77.7 µM 0.816456198301094 0.179969062959403 no 670 0.207119632872567 1011 6739311 SGTC_800 3448-7362 155 µM 0.81619394499115 0.180046635484016 no 671 0.207194609694364 1163 15991913 SGTC_708 3448-5400 146 µM 0.81616988120648 0.180053754418964 no 672 0.207201490205957 1034 3462195 SGTC_946 3434-1334 87.4 µM 0.814816873334081 0.180454307204773 no 673 0.207588570505433 988 4047976 SGTC_407 eburnamonine 100 µM 0.814441537076854 0.180565523030817 no 674 0.20769602563961 963 3195 SGTC_631 k072-0230 41.5 µM 0.809316452897313 0.182088434591941 no 675 0.209166572422336 1059 5773147 SGTC_701 4424-0219 185 µM 0.808821945449691 0.182235800362471 no 676 0.209308785601083 1081 2911779 SGTC_2860 9025725 38.96 µM 0.808799697563568 0.182242432098981 no 677 0.209315185108316 965 40546248 SGTC_848 0368-0089 85.6 µM 0.808665978048347 0.182282294910173 no 678 0.209353651368619 1031 762535 SGTC_894 0960-0238 55.9 µM 0.80706295861908 0.182760591380187 no 679 0.209815105751213 1036 6741907 YDL195W SEC31 SGTC_1395 3486-0190 4.35 µM 0.804440076270223 0.183544874557212 no 680 0.210571431930733 1076 6748079 SGTC_1898 st060199 18.6 µM 0.80117630881979 0.18452371661297 no 681 0.211514792221876 1070 688866 SGTC_752 1896-0090 130 µM 0.800750303986753 0.184651719563404 no 682 0.211638107097213 1029 772567 SGTC_237 nikkomycin 200 µM 0.798639416880754 0.185286798394286 no 683 0.212249762485243 1055 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2917 7979103 53.79 µM 0.797439163356351 0.185648509252158 no 684 0.212598010939661 1054 2980565 SGTC_2651 TUB2.036 5 µM 0.795979070211821 0.186089116113015 no 685 0.213022100320235 1178 15992207 YFL037W TUB2 SGTC_753 1322-0200 289 µM 0.795399851720019 0.186264084144026 no 686 0.213190473086723 1072 5403907 SGTC_2132 5317594 122.667 µM 0.792654658279757 0.187094727028996 no 687 0.213989527089489 995 794577 SGTC_3188 9110789 49.47 µM 0.792306933291806 0.187200105189718 no 688 0.214090864987909 1044 849217 SGTC_1098 clofazimine 15.1 µM 0.789338317177243 0.188101238745099 no 689 0.21495714854272 1055 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2009 4012297 12.05 µM 0.788936416425444 0.188223442527291 no 690 0.215074585040666 988 45595307 SGTC_428 3448-4153 16.5 µM 0.788324794102492 0.188409509187389 no 691 0.215253374215555 1002 3834874 SGTC_1610 st001799 48.1 µM 0.786928034555443 0.188834854086016 no 692 0.215661997626055 961 621897 SGTC_2788 5282734 71.43 µM 0.784503172072298 0.189574683580286 no 693 0.216372460691421 1092 743706 SGTC_3069 9117009 49.47 µM 0.784158081548947 0.189680116024634 no 694 0.216473679132864 941 41904981 SGTC_2748 diazoxide 86.69 µM 0.780776152985088 0.190715274381462 no 695 0.2174670810117 990 3019 A potassium channel activatior. SGTC_2671 danthron 100 µM 0.779823649712735 0.19100744614232 no 696 0.217747341931734 1051 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2890 9046729 58.44 µM 0.778369598123301 0.191453992385001 no 697 0.218175578081828 995 903329 SGTC_320 4092-0846 5.34 µM 0.777410041921848 0.191749026762146 no 698 0.218458444864164 1076 1359356 SGTC_2790 5423970 71.43 µM 0.776716978350521 0.191962295813107 no 699 0.218662883801912 1086 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1062 mesoridazine 14.2 µM 0.775106880505302 0.192458314147349 no 700 0.219138253109808 1077 4078 A neuroleptic. SGTC_1320 1313-0481 95.3 µM 0.773105981490093 0.193075816339753 no 701 0.219729830719354 1118 6813365 YLR208W SEC13 SGTC_2831 7999036 19.48 µM 0.771689692772635 0.193513630849583 no 702 0.220149118442211 1082 2988270 SGTC_1419 3993-2473 62.6 µM 0.770770654998059 0.19379805487195 no 703 0.220421441939396 1098 704026 SGTC_2570 licareol 100 µM 0.767959176019098 0.194669733018038 no 704 0.221255719452626 1016 443158 SGTC_2669 eugenol 100 µM 0.767646799642005 0.194766730017254 no 705 0.221348525290753 1061 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1372 2752-0194 270 µM 0.767083924009696 0.194941584548553 no 706 0.221515809691774 1027 823334 SGTC_2464 5717415 7.67 µM 0.761299991336925 0.196743859132441 no 707 0.223238952878706 1065 5285744 SGTC_898 1000-0849 28.3 µM 0.761186045351185 0.196779465785187 no 708 0.223272976006645 1106 6751807 SGTC_1583 clindamycin 39.6 µM 0.760774921235569 0.19690796921334 no 709 0.223395758073447 1021 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2980 9014342 25.29 µM 0.759356820294805 0.197351609083611 no 710 0.223819568080114 1048 2996599 SGTC_1021 4476-0760 85.3 µM 0.758328309097528 0.197673747283702 no 711 0.224127232002191 1108 746768 SGTC_168 3970-0862 530.542 µM 0.757191792782168 0.198030082947285 no 712 0.224467483245443 1146 3135186 SGTC_1747 st037496 66.6 µM 0.757110924065457 0.198055452753923 no 713 0.22449170495779 1113 723305 SGTC_492 tmb-8 126 µM 0.755661568020294 0.198510471595485 no 714 0.22492606595655 987 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3250 9135583 49.47 µM 0.755362878656551 0.198604322096424 no 715 0.225015640057069 1084 7699353 SGTC_297 0986-0032 24 µM 0.75472142606707 0.198805961870058 no 716 0.225208073897602 1086 2847425 SGTC_1196 1588-0294 184 µM 0.754200250607379 0.198969883526043 no 717 0.22536449357637 1052 6144269 SGTC_660 4031-1742 102 µM 0.753799647511553 0.199095937751618 no 718 0.225484767838594 1063 6738706 SGTC_2490 carminic acid 95.39 µM 0.753222738720688 0.199277553037751 no 719 0.225658038706585 1064 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1970 st070122 35.8 µM 0.752927266586834 0.199370608540107 no 720 0.225746811037809 1127 102928 SGTC_295 k015-0027 31 µM 0.75125976362335 0.199896259435036 no 721 0.226248169652962 1092 3887424 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.749807303677395 0.20035480027977 no 722 0.22668538464566 1225 5282309 SGTC_3076 9116187 49.47 µM 0.746407135917666 0.201430699670346 no 723 0.227710754950154 1066 27241210 SGTC_2789 5281112 71.43 µM 0.745885751906963 0.201595984446288 no 724 0.227868216458798 1106 765948 SGTC_423 5-fluorouracil 457 µM 0.745802848390135 0.201622273306998 no 725 0.227893259527492 1096 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_25 0118-0223 35.662 µM 0.745140891070311 0.201832254868103 no 726 0.228093275732179 1136 5333628 SGTC_852 0418-0143 439 µM 0.744847244616331 0.201925445293292 no 727 0.228182035181229 1172 5369229 SGTC_1660 st012960 28.1 µM 0.742535642135438 0.202659944974202 no 728 0.228881432620636 1092 24207266 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.742383137317114 0.202708458668237 no 729 0.228927616679152 1158 5357218 A potent inhibitor of glutathione S-transferases. SGTC_571 k831-0106 44.2 µM 0.74166896765981 0.202935737314626 no 730 0.229143963046379 1092 4783639 SGTC_627 1391-0720 175 µM 0.73910570145445 0.203752728346648 no 731 0.22992140752101 1070 997839 SGTC_1451 4152-0210 104 µM 0.739020097106307 0.203780046852681 no 732 0.229947396967725 1119 659563 SGTC_2514 salinomycin 42.74 µM 0.738947798860344 0.203803120746622 no 733 0.229969347967742 1168 23682228 A polyether potassium ionophore. SGTC_3194 9111903 49.47 µM 0.737152164310798 0.204376694764405 no 734 0.230514909864036 1128 17087251 SGTC_404 fumagillin 50 µM 0.737061923321911 0.204405545503419 no 735 0.230542346571786 1110 12015870 A methionine aminopeptidase binder. SGTC_3107 9121808 49.47 µM 0.736389323660142 0.20462065715686 no 736 0.230746900046728 1095 662681 SGTC_1269 0831-0796 3.05 µM 0.734003732303206 0.20538470523073 no 737 0.231473231684201 1127 927758 SGTC_2696 st077691 74.316 µM 0.733905012771859 0.205416359211495 no 738 0.231503315873731 1096 757133 SGTC_3230 9131665 49.47 µM 0.732428491652169 0.205890144811956 no 739 0.231953536924678 1084 15943720 SGTC_1195 1502-0147 41.1 µM 0.731775423633292 0.206099907665925 no 740 0.232152825939697 1169 817940 SGTC_1035 k081-0041 55.2 µM 0.731609555040501 0.206153204171577 no 741 0.232203457260953 1172 731709 SGTC_1003 4049-0218 100 µM 0.731500363048863 0.206188293944868 no 742 0.232236791426436 1153 295161 SGTC_1187 1391-0724 117 µM 0.729761194042791 0.206747667843296 no 743 0.232768084308508 1158 6997986 SGTC_2115 tiliquinol 12.7705 µM 0.728895225395785 0.207026526552493 no 744 0.2330328778244 1112 71208 A bioactive hydroxyquinoline. SGTC_747 3448-8087 38.7 µM 0.728826843650631 0.207048556277884 no 745 0.233053794530366 1163 5168703 SGTC_1397 3532-0190 20.1 µM 0.727861279712737 0.20735976844216 no 746 0.233349253871732 1078 5322280 SGTC_2713 st079149 53.4 µM 0.727419363479639 0.207502295240653 no 747 0.233484548061429 1139 3103253 SGTC_739 1486-1183 203 µM 0.719659385589888 0.210014464439025 no 748 0.235867369211644 1158 4346692 SGTC_790 1575-0012 79.1 µM 0.718732378779145 0.21031575846175 no 749 0.236152914602488 1192 378741 YLR208W SEC13 SGTC_265 mycophenolic acid 32.932 µM 0.718587152573658 0.21036298259629 no 750 0.236197665795401 1239 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2930 9013230 14.89 µM 0.718343263500408 0.210442303571652 no 751 0.23627283028015 1141 2995857 SGTC_3200 9114385 49.47 µM 0.717506448167942 0.210714597650527 no 752 0.2365308295666 1156 17018030 YLR208W SEC13 SGTC_610 4215-0184 155 µM 0.717072227683601 0.210855971484509 no 753 0.236664765543221 1168 5605015 SGTC_2357 9067248 200 µM 0.715673071483481 0.21131188803102 no 754 0.237096621094483 1150 9150235 SGTC_1197 1601-0112 267 µM 0.713153409003879 0.21213437753393 no 755 0.237875416546095 1174 7350313 SGTC_2647 atorvastatin 60.16 µM 0.711978597702199 0.212518508283039 no 756 0.238239014633922 1134 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1337 1486-1011 40.3 µM 0.706147588459986 0.214431090499787 no 757 0.240048180017054 1211 X1337 SGTC_3287 9117173 37.0625 µM 0.705547747384287 0.214628405694173 no 758 0.240234714429726 1151 2789709 SGTC_3127 9126946 49.47 µM 0.705512051384276 0.214640151068859 no 759 0.240245817413551 1105 27243249 SGTC_1279 0874-0590 65.2 µM 0.705452453680192 0.214659761867879 no 760 0.240264355473507 1174 3523074 SGTC_247 mechlorethamine 29.705 µM 0.705342590420278 0.21469591542419 no 761 0.240298530840983 1114 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2243 6634756 200 µM 0.704704881408246 0.214905841152242 no 762 0.240496956458979 1207 885676 SGTC_858 0438-0351 2.77 µM 0.703947241808204 0.215155401407685 no 763 0.240732814868448 1178 2799119 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.702948743690319 0.215484555291679 no 764 0.241043846362615 1202 364106 SGTC_600 1495-0418 41.6 µM 0.701326143104421 0.216020066418261 no 765 0.241549751085828 1193 5377768 SGTC_2221 6807166 181.081 µM 0.700235536288915 0.216380435061657 no 766 0.241890111153812 1148 674925 SGTC_2816 7982706 58.44 µM 0.699558665317921 0.216604268065666 no 767 0.242101481998084 1184 2981853 SGTC_2895 9054447 58.44 µM 0.697232171774472 0.217374631824406 no 768 0.242828754157463 1217 2697450 SGTC_2358 9037157 4 µM 0.696813152974891 0.217513548001981 no 769 0.242959866817481 1201 2388925 SGTC_776 4476-4378 112 µM 0.695403556475905 0.217981243716441 no 770 0.243401216183431 1162 2892008 SGTC_1185 1319-0113 81.3 µM 0.694139036176228 0.218401296948768 no 771 0.243797510030737 1202 4672763 SGTC_1784 st039334 36.3 µM 0.693656357058315 0.218561758024584 no 772 0.2439488708527 1240 3496984 SGTC_351 caspofungin 25 nM 0.692807299040198 0.218844182168254 no 773 0.244215245505892 1257 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1398 3558-0053 112 µM 0.690913387084695 0.219474914503446 no 774 0.244809986382024 1127 4532369 SGTC_3118 9124250 49.47 µM 0.690698340514825 0.219546597746213 no 775 0.244877566221352 1121 1504786 SGTC_203 k066-0004 30.888 µM 0.690587281993562 0.219583623062181 no 776 0.244912471043885 1275 6795412 SGTC_3306 9127676 59.7925 µM 0.689125432744643 0.220071316768582 no 777 0.245372168259258 1207 41905287 SGTC_2198 6589944 200 µM 0.689111007268488 0.220076132406602 no 778 0.245376706844429 1166 5290268 SGTC_3316 9136639 10.545 µM 0.689105850393153 0.220077853934282 no 779 0.245378329326459 1201 4903665 SGTC_1643 st009866 20.2 µM 0.687895826303543 0.220482011660936 no 780 0.24575919253565 1211 3156273 YOR207C RET1 SGTC_3309 9129340 25.759 µM 0.686775735092023 0.220856509891049 no 781 0.246112031443592 1228 17158987 SGTC_396 dithiazanine 1.25 µM 0.686342198737994 0.221001558824987 no 782 0.246248672233299 1187 10578 An antihelmenthic. SGTC_2371 9071574 200 µM 0.686254091384238 0.221031043704551 no 783 0.246276446637786 1184 45596039 SGTC_2517 totarol 10 µM 0.68587586774005 0.221157640761695 no 784 0.246395694542312 1181 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3142 9086498 49.47 µM 0.683741585096971 0.22187279384804 no 785 0.247069179553675 1150 25236367 SGTC_139 0099-0334 718.624 µM 0.683329333698969 0.222011082632943 no 786 0.247199381210312 1262 97690 SGTC_3336 9143619 71.43 µM 0.68248215065809 0.222295422656416 no 787 0.247467062779855 1242 45595730 SGTC_1457 k015-0032 57.3 µM 0.681638465087953 0.222578795194656 no 788 0.247733793122949 1208 4302660 SGTC_2027 5150920 200 µM 0.679687567882002 0.223234840084566 no 789 0.248351154752712 1208 786715 SGTC_53 0973-0023 39.979 µM 0.67921292587494 0.223394618320729 no 790 0.24850147920799 1204 674768 SGTC_1477 0139-0234 16 µM 0.678572500667162 0.223610307074289 no 791 0.248704385882614 1226 620880 SGTC_115 0527-0192 112.043 µM 0.678426829860935 0.223659384060421 no 792 0.248750551249963 1252 4233931 SGTC_2793 7325131 81.82 µM 0.676268502670462 0.224387249042487 no 793 0.249435093374229 1206 4176441 SGTC_2200 6600604 21.907 µM 0.676010804996208 0.224474243653625 no 794 0.249516892466135 1193 2904777 SGTC_836 0330-0104 1.35 µM 0.675293251988332 0.224716578883284 no 795 0.249744735158897 1239 46494820 SGTC_544 k015-0020 52.4 µM 0.674982747786775 0.224821489734639 no 796 0.249843362965693 1225 3008304 SGTC_895 0964-0006 13.7 µM 0.674735649671299 0.22490499724796 no 797 0.249921865388081 1209 6738897 SGTC_2140 5586273 200 µM 0.674490759476595 0.224987775933268 no 798 0.249999679274407 1222 854421 SGTC_195 4234-0266 16.654 µM 0.673957214668594 0.225168186492866 no 799 0.250169257702755 1227 2303354 SGTC_1896 st058441 89 µM 0.673673694030074 0.22526408828393 no 800 0.250259394884479 1187 688759 SGTC_1237 0330-0133 46.1 µM 0.673471647591842 0.225332445272451 no 801 0.250323640209426 1188 X1237 YHR072W ERG7 SGTC_1000 4048-0884 8.67 µM 0.673465201204179 0.225334626428007 no 802 0.250325690130986 1228 13040088 SGTC_2384 9036245 200 µM 0.673003455742519 0.225490890552618 no 803 0.250472546205451 1230 6462766 SGTC_2905 7799065 20.05 µM 0.668589738964488 0.226987674572227 no 804 0.251878609941915 1185 1296806 SGTC_1944 st076371 56.9 µM 0.666618879299458 0.227657839698394 no 805 0.252507803369231 1217 24208455 SGTC_547 1120-0019 610 nM 0.664165620333754 0.22849359247798 no 806 0.253292157419935 1219 3676939 SGTC_809 3998-0021 90 µM 0.66377073782199 0.228628278136125 no 807 0.253418528527202 1193 715485 SGTC_226 1,3-diallylurea 8.28947 mM 0.663497325949813 0.228721558972011 no 808 0.25350604576247 1211 74537 YKL182W FAS1 SGTC_644 1498-1197 63.3 µM 0.663147190165661 0.228841047157871 no 809 0.253618144973155 1278 6741615 SGTC_1311 1190-0148 100 µM 0.661384725561367 0.229443041871863 no 810 0.254182809471468 1298 1961333 SGTC_2104 5389443 200 µM 0.660924354232398 0.229600434277114 no 811 0.254330413351565 1286 2244536 SGTC_1707 st032323 6.317 µM 0.659274727824949 0.230164907283952 no 812 0.254859683946299 1191 3132057 YMR211W DML1 SGTC_3111 9122088 49.47 µM 0.659252702023576 0.230172449372208 no 813 0.25486675466196 1173 16876704 SGTC_1010 4112-3296 15.2 µM 0.658504361775708 0.230428778620994 no 814 0.255107047597803 1286 704384 SGTC_3162 9099653 49.47 µM 0.656828096971867 0.231003528862462 no 815 0.255645727882886 1234 25237511 SGTC_255 tunicamycin 200.472 nM 0.655655589741595 0.23140602811663 no 816 0.256022874653078 1233 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_400 oxethazaine 37.5 µM 0.655148271016451 0.231580302048104 no 817 0.256186147885634 1246 4621 A local anesthetic. SGTC_635 k038-0028 24.7 µM 0.654773253568723 0.231709174908631 no 818 0.256306876746938 1291 4035102 SGTC_1735 st034310 56.75 µM 0.654246865597103 0.231890132880798 no 819 0.256476386129669 1332 871153 SGTC_1013 4112-3890 241 µM 0.653755750806976 0.232059035836469 no 820 0.256634589363162 1220 705171 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.653187378675425 0.23225459440956 no 821 0.256817742988152 1289 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_501 nsc-95397 161 µM 0.652380078650319 0.232532517942477 no 822 0.257078006215177 1298 262093 SGTC_3314 9135860 59.4275 µM 0.652265357428797 0.2325720272157 no 823 0.257115002001645 1257 25252478 SGTC_1283 0922-0125 16.4 µM 0.651538915670447 0.232822295850413 no 824 0.257349332280589 1261 3360884 SGTC_1052 3253-3998 198 µM 0.649767324299316 0.233433259087127 no 825 0.257921264308209 1252 5450317 SGTC_252 miconazole 1.30953 nM 0.649533857566662 0.233513840311745 no 826 0.257996684732288 1224 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1215 3852-0577 11.2 µM 0.649121426973251 0.233656228744785 no 827 0.258129946610638 1335 2884876 SGTC_2409 alverine citrate 63.97 µM 0.648862596569767 0.233745612493221 no 828 0.258213596422968 1385 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_606 k015-0008 38.6 µM 0.64789448924981 0.234080103859935 no 829 0.258526597623333 1323 1970475 SGTC_1058 3448-5425 97.3 µM 0.647806847203641 0.234110398198125 no 830 0.258554943089231 1210 7279705 SGTC_3054 9094397 49.47 µM 0.644743193935005 0.235170743574505 no 831 0.259546809963972 1253 2598354 SGTC_391 gliotoxin 8.33 µM 0.64458239150284 0.235226471244336 no 832 0.259598924446726 1320 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_285 1486-1325 46 µM 0.6438086222888 0.235494730537817 no 833 0.25984977094282 1292 22310230 SGTC_3160 9100216 49.47 µM 0.643651539296405 0.235549210499193 no 834 0.259900710589697 1231 17191039 SGTC_1701 st028638 40.4 µM 0.643491511255036 0.235604719020136 no 835 0.259952610567918 1271 3490878 SGTC_2382 9035899 200 µM 0.643480704376276 0.23560846783485 no 836 0.259956115626152 1294 6462679 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.643222704092557 0.235697975717053 no 837 0.260039801604614 1372 6728940 SGTC_960 1222-0186 7.7 µM 0.643144095504996 0.235725251073584 no 838 0.26006530215342 1292 3126296 SGTC_1932 st074806 40.9 µM 0.642011710689811 0.236118355411475 no 839 0.260432789687936 1368 17251235 SGTC_1861 st057647 17.4 µM 0.641952472271094 0.236138929804432 no 840 0.260452021412952 1350 688668 SGTC_327 1273-0057 3.96 µM 0.641907828090547 0.236154436051733 no 841 0.260466515608639 1222 3108138 SGTC_1199 1638-0010 4.46 µM 0.640813764893476 0.236534611872064 no 842 0.260821844334761 1268 3111136 SGTC_2219 9098279 200 µM 0.640358163028435 0.23669302815304 no 843 0.260969887753151 1277 902349 SGTC_1464 k208-0027 110 µM 0.638920823462034 0.237193184471993 no 844 0.2614372203653 1342 X1464 SGTC_3269 9137823 49.47 µM 0.638892977745597 0.237202879777476 no 845 0.261446278286079 1222 17682936 SGTC_1261 0712-0010 12.7 µM 0.636849815102864 0.237914860650849 no 846 0.262111337184539 1300 2840123 SGTC_2791 5663188 71.43 µM 0.636815673483908 0.237926767925908 no 847 0.262122457799972 1284 54690634 SGTC_3224 9130643 49.47 µM 0.635999745331554 0.238211429269332 no 848 0.262388294009772 1329 17644395 SGTC_1948 st076329 66.6 µM 0.635050105399602 0.238542974860274 no 849 0.262697868385566 1198 24208413 SGTC_2269 7935389 174.42 µM 0.634752490435451 0.238646932445318 no 850 0.262794926723527 1264 97605 SGTC_417 st075190 100 µM 0.633483391418962 0.23909050976868 no 851 0.263209011669802 1312 222757 SGTC_1880 MG-132 525 µM 0.631839610673186 0.239665715639192 no 852 0.263745843731983 1253 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3036 9090181 49.47 µM 0.631590167536079 0.23975306887569 no 853 0.26382735657546 1328 25236586 SGTC_760 0568-0725 82.9 µM 0.628892199823796 0.240698987426678 no 854 0.264709816501849 1302 3916171 SGTC_33 0986-0033 35.816 µM 0.627360075557658 0.24123705940354 no 855 0.26521161600602 1259 2848082 SGTC_2060 5238662 140 µM 0.627357268054872 0.241238045979755 no 856 0.265212535959123 1278 790130 SGTC_2902 5787006 60.46 µM 0.627187966666274 0.24129754373089 no 857 0.26526801506554 1290 591003 SGTC_2023 5144124 124 µM 0.623262463083628 0.242679320601112 no 858 0.266556030273939 1300 2830192 SGTC_2395 5646831 180.19 µM 0.621752955995239 0.243211805082455 no 859 0.267052162228823 1350 6808628 SGTC_3329 9141233 27.5565 µM 0.619429638173142 0.244032597146211 no 860 0.267816680625137 1324 4909101 YNL103W MET4 SGTC_1756 st041558 35.5 µM 0.618679190449808 0.244298037563381 no 861 0.268063860735153 1381 3955792 SGTC_1271 0832-2808 169 µM 0.618490647441108 0.244364751452265 no 862 0.268125980484211 1328 3663794 SGTC_626 0214-0009 33 µM 0.618150959828603 0.244484970987248 no 863 0.268237916516095 1383 3437874 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.617970806519067 0.244548742340305 no 864 0.268297291325144 1337 688761 SGTC_1569 carminic acid 40.6 µM 0.616480987281052 0.245076457474769 no 865 0.26878855823292 1326 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2625 euphol 100 µM 0.616260124662713 0.245154742251172 no 866 0.268861425972124 1329 6708538 A triterpene alcohol. SGTC_1689 st020265 53.493 µM 0.616007851376201 0.245244176991742 no 867 0.268944668959513 1358 5758320 YPR016C TIF6 SGTC_990 3985-0011 41.3 µM 0.615825274680292 0.245308914164121 no 868 0.269004922130165 1310 5399565 YGL099W LSG1 SGTC_80 0159-0065 512.242 µM 0.614783578931905 0.245678449318537 no 869 0.269348827613351 1285 1548079 SGTC_2404 5161160 200 µM 0.614275386324594 0.245858835948213 no 870 0.26951668231626 1298 2831543 SGTC_922 1866-0035 480 µM 0.61425519992314 0.245866002724618 no 871 0.269523350914801 1331 3156169 SGTC_1634 st006576 41 µM 0.614141879939722 0.245906236790166 no 872 0.269560787823143 1328 3915356 SGTC_2463 5473429 200 µM 0.612334988011303 0.246548247739514 no 873 0.270158072696919 1326 5399405 SGTC_2920 7982904 15.77 µM 0.608819131984554 0.247800043792719 no 874 0.271322165415902 1310 6456808 SGTC_977 1348-1378 135 µM 0.608693479100211 0.247844844343189 no 875 0.271363815049263 1306 X977 SGTC_455 paf C-16 10 µM 0.608383768689233 0.24795528762111 no 876 0.271466487059287 1306 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1686 st019653 115.5 µM 0.60796218942455 0.248105665725936 no 877 0.271606275772245 1361 97252 SGTC_1450 4112-4260 37.6 µM 0.606850810659194 0.248502329649122 no 878 0.271974962298491 1322 1633175 SGTC_268 camptothecin 39.6153 µM 0.605781172691684 0.248884414682698 no 879 0.272330036724365 1347 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_446 go6976 132 µM 0.603776104569538 0.249601486058286 no 880 0.2729962541452 1299 3501 A protein kinase C inhibitor. SGTC_2711 st079103 59.1 µM 0.601653693536211 0.250361716775948 no 881 0.27370233991977 1337 54693780 SGTC_1260 0700-1617 7.75 µM 0.600885936196404 0.250637023342422 no 882 0.273957980500234 1362 2853078 SGTC_3205 9113483 49.47 µM 0.600514811686456 0.250770160639362 no 883 0.2740815963296 1377 17018033 SGTC_2695 st077686 51.995 µM 0.600347499229674 0.250830194594865 no 884 0.274137334530384 1306 2876092 SGTC_1214 0358-0031 63.7 µM 0.599904467729444 0.250989196984604 no 885 0.274284952365306 1512 4301366 SGTC_657 3534-0529 86.7 µM 0.599430175939752 0.251159477673861 no 886 0.274443029599044 1407 1049549 SGTC_232 clozapine 119 µM 0.597916494025601 0.251703329614141 no 887 0.274947826837239 1328 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_216 k038-0035 28.382 µM 0.597302789984712 0.251924004870518 no 888 0.275152621044609 1291 4444231 YPR107C YTH1 SGTC_1715 st032160 10.2275 µM 0.595248450944029 0.252663444979317 no 889 0.27583870395852 1315 5289825 SGTC_3169 9102970 49.47 µM 0.595189605960851 0.25268464250795 no 890 0.275858368659562 1393 17027839 SGTC_2187 6125751 200 µM 0.593971059055551 0.25312380594741 no 891 0.276265735011229 1340 874498 SGTC_3101 9120531 49.47 µM 0.59365525538091 0.253237686838552 no 892 0.27637135790755 1393 24824904 SGTC_770 0389-1121 67.2 µM 0.592631660312554 0.253606987076678 no 893 0.276713843004444 1441 6753108 SGTC_676 falcarinol 140 µM 0.592194583094099 0.253764765188425 no 894 0.276860148180773 1446 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_146 3448-8650 53.125 µM 0.591817611921443 0.253900887330387 no 895 0.276986364161546 1382 2891488 YIL048W NEO1 SGTC_2505 galangin 7.89 µM 0.590174850806547 0.254494526088357 no 896 0.277536715478644 1307 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1722 st034304 3.6505 µM 0.589373214931248 0.254784474202327 no 897 0.277805470221831 1348 4036148 YLR033W RSC58 SGTC_512 prima-1 270 µM 0.589289437622021 0.2548147860588 no 898 0.277833564556939 1411 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1041 0206-0046 107 µM 0.585734162589491 0.256102874448838 no 899 0.27902708642533 1384 50494 SGTC_497 capsazepine 133 µM 0.584981578560344 0.256375973094585 no 900 0.279280051691133 1304 2733484 A calcium channel blocker. SGTC_147 4466-0538 29.23 µM 0.584053936148139 0.256712805855746 no 901 0.279592012405912 1415 6742687 YHR072W ERG7 SGTC_2322 7413319 38.22 µM 0.583727761817737 0.256831296520153 no 902 0.27970174310746 1407 1840400 SGTC_2614 arthonioic acid 13.39 µM 0.582786867494606 0.25717325841081 no 903 0.280018393317238 1303 6710684 SGTC_3353 9151644 39.2805 µM 0.581621719731919 0.257597051607695 no 904 0.280410754854052 1353 4909158 SGTC_3342 9147791 14.508 µM 0.581529350544589 0.257630664084934 no 905 0.28044187140516 1323 1838168 SGTC_2681 menadione 3.18 µM 0.578357713813365 0.258786179801953 no 906 0.281511318426085 1372 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_490 phenamil 164 µM 0.576312984674728 0.25953255107404 no 907 0.282201823904688 1403 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_48 0382-0018 55 µM 0.576286766443186 0.259542128520213 no 908 0.282210683098093 1472 762596 SGTC_955 1216-0110 33 µM 0.576195208416992 0.259575575840863 no 909 0.282241621790007 1323 3619719 SGTC_1004 4084-0029 199 µM 0.575964677788416 0.25965980148998 no 910 0.28231952842694 1391 716894 YLR208W SEC13 SGTC_1452 4194-0072 190 µM 0.573464100448994 0.260574306929351 no 911 0.283165249748116 1475 1343545 SGTC_1928 4'-methoxychalcone 40.3 µM 0.573210082337685 0.260667298542065 no 912 0.283251229284907 1514 641818 SGTC_1122 capsaicin 818.572 nM 0.572370918196298 0.260974623308165 no 913 0.283535356845725 1473 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_56 0957-0365 83.25 µM 0.5723463435613 0.260983626016044 no 914 0.283543679482119 1330 6752360 SGTC_1090 efavirenz 20.7 µM 0.570287309994207 0.261738502208355 no 915 0.284241423220973 1409 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3119 9125183 49.47 µM 0.569738865129571 0.261939760043759 no 916 0.284427412819963 1279 22695334 SGTC_61 0978-8327 98.565 µM 0.566342626760347 0.263187811471524 no 917 0.285580444196534 1398 6150059 YHR072W ERG7 SGTC_27 0485-0001 32.618 µM 0.56607689858196 0.263285589383688 no 918 0.285670753331495 1349 2054479 SGTC_2453 5731132 22.18 µM 0.564925629554374 0.263709427006521 no 919 0.286062175113367 1490 1362040 SGTC_1626 st003712 1.76 µM 0.563054233171779 0.264399120059009 no 920 0.286698977387553 1394 24207035 SGTC_2190 6049624 200 µM 0.562615363575882 0.264560995888035 no 921 0.286848413995689 1381 2265554 SGTC_1333 1482-0047 286 µM 0.562223462613099 0.264705590071435 no 922 0.286981888813072 1361 3811116 SGTC_2097 5376186 200 µM 0.561429189005832 0.264998765240333 no 923 0.28725249512308 1419 742755 SGTC_1363 1636-0063 10.4 µM 0.559778916532718 0.265608426096042 no 924 0.287815123101546 1412 6072185 SGTC_2523 spermine 47.74 µM 0.559772406922436 0.265610832351864 no 925 0.287817343455587 1397 1103 A DNA binding polyamine. SGTC_2236 dapsone 200 µM 0.558936971793874 0.265919739901615 no 926 0.28810236800468 1392 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2284 7945075 39.21 µM 0.558876650994894 0.265942050951802 no 927 0.28812295274467 1463 1245402 SGTC_3323 9138564 53.9225 µM 0.558704780988625 0.266005626270716 no 928 0.288181607951395 1477 43912313 YNL103W MET4 SGTC_1057 3448-5381 134 µM 0.558628365669273 0.266033895037889 no 929 0.288207688518658 1456 5497911 SGTC_607 4491-0986 66.8 µM 0.558152333821346 0.2662100305486 no 930 0.28837018337181 1471 698981 YDR232W HEM1 SGTC_2898 9056270 58.44 µM 0.556145874976997 0.266953084280335 no 931 0.289055568195677 1358 19154699 SGTC_29 0299-0004 12.984 µM 0.554320732019883 0.267629899815005 no 932 0.289679682140601 1310 16871 A napthoquinone isolated from Swertia calycina. SGTC_2448 5185112 27.17 µM 0.553526384338864 0.267924736703733 no 933 0.289951509469703 1373 5718189 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.553324776550084 0.267999593195608 no 934 0.290020519074809 1433 5393153 SGTC_2650 prasterone 100 µM 0.552957207968455 0.268136097629994 no 935 0.290146356261486 1385 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.55280724813295 0.268191798462611 no 936 0.290197702392187 1380 688667 SGTC_3112 9123419 49.47 µM 0.552777332498544 0.268202910972829 no 937 0.290207945991387 1421 17015854 SGTC_989 1501-0895 10.3 µM 0.552529269414993 0.268295065814319 no 938 0.290292893346454 1423 2830112 SGTC_2228 7354201 200 µM 0.552113666695002 0.268449496919644 no 939 0.290435239495934 1451 753451 SGTC_882 0843-0131 351 µM 0.551178579906069 0.268797123053622 no 940 0.290755631117887 1410 5425421 SGTC_2325 6158266 200 µM 0.5499531090488 0.269253043893773 no 941 0.291175767959277 1410 3623240 SGTC_1437 4092-1038 11.6 µM 0.54926433174907 0.269509464879519 no 942 0.291412030719524 1383 3977136 SGTC_3344 9148862 3.898 µM 0.548653695626634 0.269736897431765 no 943 0.291621564442246 1479 4905352 SGTC_1679 SEC14.276 6.7 µM 0.547617284205012 0.270123130669443 no 944 0.291977359415434 1464 1005053 YMR079W SEC14 SGTC_1525 8-methoxypsoralen 92.5 µM 0.547379626709309 0.270211736040928 no 945 0.29205897455097 1537 4114 Related to psoralen; DNA damaging agent. SGTC_2863 9028737 58.44 µM 0.546517990579188 0.270533099949761 no 946 0.292354962281985 1450 6460917 SGTC_2499 avocadenofuran 51.48 µM 0.544319290737042 0.271354012034726 no 947 0.293110887204425 1356 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_545 4218-0007 221 µM 0.543539215702076 0.271645560843997 no 948 0.293379298918011 1404 2840508 SGTC_1759 st043059 70 µM 0.542980354366882 0.271854528078089 no 949 0.293571664424951 1389 669426 SGTC_1232 0279-0259 161 µM 0.542687154158789 0.271964192326265 no 950 0.293672610140408 1425 1560000 SGTC_1039 k821-0043 94 µM 0.541719048135683 0.272326444507006 no 951 0.294006032804624 1486 15992768 SGTC_1658 st012944 20 µM 0.541225342832378 0.27251127460653 no 952 0.294176135811702 1377 24207260 SGTC_979 1426-2828 121 µM 0.540598198113233 0.272746150644082 no 953 0.294392280061844 1497 747872 SGTC_1966 st070145 16.1 µM 0.540337929020533 0.272843655193676 no 954 0.294482002839528 1349 3748532 SGTC_2476 5806916 10.51 µM 0.539462024944755 0.273171921880911 no 955 0.294784046637718 1425 2870194 SGTC_1854 st056233 32.9 µM 0.537932836270423 0.273745491766514 no 956 0.295311708956997 1432 5393174 SGTC_690 glyoxal 20.3 µM 0.536437982642373 0.274306758367178 no 957 0.295827943339425 1335 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3040 9091894 49.47 µM 0.535901541275022 0.27450831226361 no 958 0.296013299602621 1396 25236966 SGTC_519 k048-0011 62.8 µM 0.535263829599554 0.274748010874476 no 959 0.296233717066229 1462 6836379 SGTC_2936 9038235 15.59 µM 0.534959067549076 0.274862599137295 no 960 0.296339081026275 1414 4749415 SGTC_2948 9070189 9.45 µM 0.533822751233322 0.275290053140926 no 961 0.296732085743073 1451 6473636 YDL196W YDL196W SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.533476676678574 0.275420302770254 no 962 0.296851825977419 1461 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3199 9111318 49.47 µM 0.533093915103871 0.275564395335647 no 963 0.296984285503337 1475 8548020 SGTC_365 0121-0052 13.6 µM 0.530602701960153 0.276503130181568 no 964 0.297847061459435 1472 3101739 SGTC_2157 5649910 96.377 µM 0.530473181511994 0.276551978709422 no 965 0.297891949211814 1394 2858091 SGTC_1005 4092-0690 4.4 µM 0.530372763754378 0.276589854093314 no 966 0.297926753000872 1403 1529343 SGTC_2746 daunorubicin 9.88 µM 0.529336421128292 0.276980888344267 no 967 0.298286047210522 1410 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_972 1319-0219 195 µM 0.528930541372579 0.277134109182059 no 968 0.298426817201521 1387 23903702 SGTC_2982 9019404 25.97 µM 0.527181387007966 0.277794894350419 no 969 0.299033816450694 1278 22333232 SGTC_3296 9122258 64.045 µM 0.527136545196389 0.277811844532829 no 970 0.2990493850213 1466 4730474 SGTC_1972 st070201 17.4 µM 0.52676600852074 0.277951926534276 no 971 0.29917804525315 1501 2829099 SGTC_2804 7954240 19.48 µM 0.526234011246242 0.278153109237132 no 972 0.299362812830074 1514 828705 SGTC_1254 0550-0035 264 µM 0.525977995114574 0.278249950860777 no 973 0.299451748042854 1522 15121435 SGTC_2616 abietic acid 100 µM 0.525799093835188 0.278317632486464 no 974 0.299513902108166 1473 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_487 nimodipine 119 µM 0.522111595513534 0.279714465082064 no 975 0.300796316725517 1431 4497 L-type voltage-gated calcium channels inhibitor SGTC_1811 st050069 61.5 µM 0.521995833606403 0.279758370965991 no 976 0.300836615738745 1455 3877702 SGTC_3196 9111891 49.47 µM 0.516837757594753 0.281718099276333 no 977 0.302634710066971 1426 18891510 SGTC_1853 st056710 91.2 µM 0.515022117531696 0.282409493984235 no 978 0.303268782282213 1624 269167 SGTC_2264 7948757 110.76 µM 0.514908024646274 0.282452967730358 no 979 0.303308646529141 1436 2971411 SGTC_2076 5212012 200 µM 0.514416655455078 0.282640234925193 no 980 0.303480358512761 1415 604802 SGTC_2443 5493264 126.67 µM 0.514383025013478 0.282653054105786 no 981 0.303492112464776 1552 5340055 SGTC_1299 1079-1439 3.74 µM 0.513501487765596 0.282989176228935 no 982 0.303800285176319 1412 323161 SGTC_439 amiodarone 34.4 µM 0.512427596127735 0.283398900405023 no 983 0.304175890715535 1528 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1344 1488-0097 29.1 µM 0.509881866715415 0.28437131258919 no 984 0.305067113274194 1491 747966 SGTC_1815 st051655 58.2 µM 0.509604233531526 0.284477458659124 no 985 0.305164378665549 1468 5984156 SGTC_2839 9003951 25.97 µM 0.509495714514507 0.284518953321947 no 986 0.305202400717584 1477 2990634 SGTC_386 1509-0011 3.07 µM 0.508383852570091 0.284944264955011 no 987 0.305592087343716 1458 3107280 SGTC_2290 7904846 200 µM 0.50532420768651 0.286116209126387 no 988 0.306665571448294 1467 2962154 SGTC_2339 9000433 200 µM 0.50491065316905 0.286274789553405 no 989 0.306810795684128 1430 2988954 SGTC_2796 7949634 45.45 µM 0.504043035021633 0.286607619469339 no 990 0.307115567909585 1440 2971588 SGTC_167 3672-0051 66.205 µM 0.503446911717655 0.286836406652931 no 991 0.307325048164894 1427 3237971 SGTC_2972 9093619 59.92 µM 0.503084998402725 0.286975348195282 no 992 0.307452256715907 1419 25236256 SGTC_1125 tnp00248 1.32998 µM 0.502145192459407 0.287336296348025 no 993 0.307782696313825 1600 24207736 SGTC_3144 9087057 49.47 µM 0.501059467654008 0.287753554283375 no 994 0.308164635748335 1534 17249618 SGTC_1314 1222-0010 41.1 µM 0.500049346284933 0.288142013724348 no 995 0.308520165824387 1486 3526027 SGTC_337 1315-0038 354 µM 0.500037930787275 0.288146405162683 no 996 0.308524184737606 1464 1626437 SGTC_1145 3546-0597 10.2 µM 0.498039337540163 0.288915732117064 no 997 0.309228158015732 1474 875334 SGTC_3157 9099274 49.47 µM 0.497944316946691 0.288952332853458 no 998 0.309261645011519 1482 17217662 SGTC_112 phenothiazine 287.218 µM 0.497904793045862 0.288967557604924 no 999 0.309275574423977 1556 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2779 methotrexate 400 µM 0.497430153194117 0.289150420089872 no 1000 0.309442873203434 1495 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3215 9129942 49.47 µM 0.49545985612505 0.289910089225311 no 1001 0.310137776108195 1495 17682944 SGTC_611 3453-1652 23.7 µM 0.494234908575002 0.290382852226561 no 1002 0.310570144403059 1547 1560575 SGTC_1172 0370-0043 85 µM 0.493631735059585 0.290615776888892 no 1003 0.310783142088902 1529 376585 SGTC_2450 5739737 12.93 µM 0.493473793655041 0.290676782811082 no 1004 0.310838926162392 1481 2262825 SGTC_3254 9136651 49.47 µM 0.492268899794561 0.291142378138826 no 1005 0.311264631366781 1454 16454030 SGTC_1511 0906-3109 28.5 µM 0.492264648772322 0.291144021436042 no 1006 0.311266133757511 1490 2882180 SGTC_796 1234-0020 70.7 µM 0.491233660842763 0.291542693325331 no 1007 0.311630596960389 1449 46495034 SGTC_1454 4239-0054 42.6 µM 0.491169962907077 0.291567332976512 no 1008 0.311653120793814 1586 1340767 SGTC_271 rotenone 740 µM 0.490893348168177 0.291674344420405 no 1009 0.31175094099627 1532 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1897 st060201 15 µM 0.488417010473568 0.292633157318833 no 1010 0.312627247734019 1458 611878 SGTC_1412 3909-8563 178 µM 0.488240734859205 0.292701465241654 no 1011 0.312689667231283 1598 23767530 SGTC_1469 k284-2957 126 µM 0.488210628019246 0.292713132574194 no 1012 0.312700328652112 1529 23884841 SGTC_1563 conessine 56.1 µM 0.487742778297558 0.292894466575794 no 1013 0.31286602352226 1558 441082 An anti-amoebic, histamine inhibitor. SGTC_839 0122-0028 230 µM 0.487584374986714 0.292955873971127 no 1014 0.312922132619749 1500 759448 SGTC_1540 guanosine 70.6 µM 0.487509083036862 0.292985064107916 no 1015 0.31294880380508 1483 6802 Guanosine is a purine nucleoside SGTC_2096 5468907 200 µM 0.487146698684321 0.293125576738748 no 1016 0.313077187400547 1593 759785 SGTC_4 0960-0234 25.671 µM 0.486629092704269 0.293326329921075 no 1017 0.313260601391477 1496 6821112 SGTC_2080 5212524 12.4 µM 0.484429781864884 0.294180041066524 no 1018 0.314040443310308 1586 260183 SGTC_2294 7971431 200 µM 0.483454759882827 0.294558884352699 no 1019 0.314386437295869 1508 5741572 SGTC_1093 fluphenazine 7.97 µM 0.483209667337905 0.29465415007662 no 1020 0.314473435921755 1543 6602611 An atypical antipsychotic. SGTC_2622 2-methoxyxanthone 59.94 µM 0.483112692532239 0.294691847415459 no 1021 0.314507861171969 1645 71034 A hepatoprotective. SGTC_2487 5918373 44.05 µM 0.483077549623003 0.294705509184563 no 1022 0.314520337010895 1547 2876279 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.482897059122143 0.294775679279371 no 1023 0.314584415020888 1526 616764 SGTC_34 0469-0683 81.75 µM 0.48173207257193 0.295228781494114 no 1024 0.314998144601814 1568 3690923 SGTC_2309 7664088 163.95 µM 0.478736084313178 0.296395491329368 no 1025 0.31606319587376 1580 704922 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.476857626364418 0.29712808435449 no 1026 0.316731753713898 1478 6708760 SGTC_3012 9080433 71.4286 µM 0.475949571494999 0.297482519636381 no 1027 0.317055152454001 1599 17688859 SGTC_2832 7992762 51.95 µM 0.474305503240936 0.298124729038426 no 1028 0.317641033855772 1372 2985177 SGTC_3026 9090633 49.47 µM 0.474113056048544 0.298199944441285 no 1029 0.317709644386768 1488 25236842 SGTC_1141 3253-0389 52.6 µM 0.473030334864262 0.298623272487121 no 1030 0.318095768602388 1533 5402031 SGTC_789 1309-1135 70.6 µM 0.472647032211079 0.298773203654151 no 1031 0.318232510904226 1481 3092424 SGTC_2192 5915882 198.485 µM 0.472577008013897 0.298800597740942 no 1032 0.318257494545514 1502 2876149 SGTC_2139 5578692 56.4705 µM 0.471503514649035 0.299220700663861 no 1033 0.318640605199699 1591 650991 YMR113W FOL3 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.470657053225278 0.299552145338332 no 1034 0.31894282898554 1532 165521 SGTC_2724 maprotiline 69.64 µM 0.470054950780927 0.299788008811532 no 1035 0.319157879225464 1570 4011 A tricyclic antidepressant. SGTC_2223 6903751 107.57 µM 0.468817352935366 0.300273080761478 no 1036 0.319600097602226 1536 5598863 SGTC_200 k038-0079 37.545 µM 0.46861249554593 0.300353408077186 no 1037 0.319673322002398 1566 3436683 SGTC_3071 9117417 49.47 µM 0.467505885028515 0.300787492624467 no 1038 0.320068991301397 1587 45595590 YGL055W OLE1 SGTC_904 1141-0088 396 µM 0.466948948763881 0.301006066231376 no 1039 0.32026820169776 1439 1378119 SGTC_569 4130-2812 160 µM 0.465756949820703 0.301474115155725 no 1040 0.320694741567952 1532 743552 SGTC_2124 5246320 200 µM 0.463559531567622 0.302337808091391 no 1041 0.321481676917932 1564 579342 SGTC_1602 st001878 87.6 µM 0.463473986778966 0.302371453817143 no 1042 0.321512328297026 1577 595405 YLR310C CDC25 SGTC_756 0508-1999 28.3 µM 0.463191843701946 0.302482435758814 no 1043 0.321613431021766 1456 6753853 SGTC_2916 7875993 68.79 µM 0.462915398506925 0.302591194129335 no 1044 0.321712504792138 1663 1299250 SGTC_876 0720-0963 56.8 µM 0.462671652359375 0.302687102658919 no 1045 0.321799870237814 1657 765861 SGTC_2126 5251174 33.877 µM 0.462113902511466 0.302906615675482 no 1046 0.321999820466082 1706 790722 SGTC_2896 9052656 71.43 µM 0.461867719046616 0.30300352850414 no 1047 0.32208809227221 1506 6469436 SGTC_3278 9139605 49.47 µM 0.461222482022885 0.303257598968037 no 1048 0.322319496767526 1598 7958859 SGTC_2295 7971645 200 µM 0.461015181173581 0.303339246581662 no 1049 0.322393856702871 1598 2978226 YKL099C UTP11 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.459287583042166 0.304020060950545 no 1050 0.323013831657225 1538 97141 SGTC_2516 gossypol 71.55 µM 0.458699697878203 0.304251890822748 no 1051 0.323224915519041 1656 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1714 st033236 13.627 µM 0.458610190116887 0.304287194711693 no 1052 0.323257058838231 1646 2916566 SGTC_3027 9089541 49.47 µM 0.457160348336263 0.304859299052867 no 1053 0.323777898191075 1531 9943819 SGTC_702 1488-0190 94 µM 0.456055832576263 0.305295459013647 no 1054 0.324174914850894 1647 949357 SGTC_1845 st056753 3.01 µM 0.455912541674581 0.305352063145157 no 1055 0.324226435234012 1480 5375839 SGTC_1984 st072354 53.1 µM 0.454782528408541 0.305798614706366 no 1056 0.324632850470648 1562 5762938 SGTC_1954 st077032 68.9 µM 0.452788908283416 0.306587145211372 no 1057 0.325350375635234 1461 698907 SGTC_3281 9140613 49.47 µM 0.452104871055444 0.306857907063839 no 1058 0.325596717360801 1452 16013766 SGTC_1817 st052116 64.4 µM 0.451889874860103 0.30694303059487 no 1059 0.325674159493651 1596 4361398 SGTC_394 menadione 8.33 µM 0.451374723687663 0.307147036951833 no 1060 0.325859748760171 1562 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1399 3562-5772 25 µM 0.451236605781493 0.307201743536039 no 1061 0.325909514698343 1513 23847490 SGTC_652 0437-0092 114 µM 0.450557537989597 0.307470775250928 no 1062 0.32615423803397 1510 3091274 SGTC_1882 5615643 20 µM 0.449330002414259 0.307957360684193 no 1063 0.32659680888181 1504 2253075 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.448392040663399 0.308329389090277 no 1064 0.326935142518705 1541 2724 A muscle relaxant with antifungal properties. SGTC_986 1493-0483 84 µM 0.448242583372277 0.308388687274737 no 1065 0.326989066641976 1602 40079 SGTC_2035 5154463 94.595 µM 0.447772984934571 0.308575036136768 no 1066 0.327158521050396 1623 2769623 SGTC_2717 st081029 62.2815 µM 0.447316844443714 0.308756091753704 no 1067 0.327323153282615 1590 5292846 SGTC_1941 st076221 61.8 µM 0.445507292321431 0.309474814114503 no 1068 0.327976595518691 1625 2828568 SGTC_2583 asiatic acid 100 µM 0.444821898491532 0.309747231121144 no 1069 0.328224233839985 1573 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_813 k007-0158 173 µM 0.443311639252209 0.310347868347549 no 1070 0.328770169068511 1668 6523916 SGTC_506 n9-isopropylolomoucine 153 µM 0.442744899367664 0.310573394171249 no 1071 0.328975131125344 1714 6610355 SGTC_1752 st044819 83.042 µM 0.442620200529025 0.310623025806146 no 1072 0.329020235493001 1493 441209 YML126C ERG13 SGTC_1050 3232-1156 69.3 µM 0.44087807353762 0.31131677340629 no 1073 0.329650634062602 1523 700529 SGTC_2088 5278280 127.392 µM 0.440486477112872 0.311472806843878 no 1074 0.329792402188753 1593 791502 SGTC_2350 9023895 38.85 µM 0.439990233031206 0.311670586283868 no 1075 0.329972090628289 1646 2997209 SGTC_79 0052-0007 94.094 µM 0.437826937349334 0.312533407897316 no 1076 0.330755871164447 1660 2801472 SGTC_1485 3909-9022 254 µM 0.435238554600387 0.313567125314945 no 1077 0.331694640087031 1570 714516 SGTC_938 3126-1755 342 µM 0.434619354748527 0.313814631534793 no 1078 0.331919371942732 1611 1777771 SGTC_188 3229-0966 278.469 µM 0.431495935439514 0.315064398728057 no 1079 0.333053903690361 1706 5722370 SGTC_415 dibenzyl ketone 100 µM 0.4311942717436 0.315185215277539 no 1080 0.333163559337135 1680 7593 SGTC_292 k038-0015 474 µM 0.431083125619489 0.315229734373167 no 1081 0.333203964878846 1601 46368540 SGTC_1710 st031758 61.5 µM 0.430774608476229 0.315353323630593 no 1082 0.333316131901132 1652 5394341 SGTC_2759 disulfiram 3.38 µM 0.430575677806219 0.315433024467819 no 1083 0.333388464672671 1526 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1061 3448-9325 110 µM 0.429947547415948 0.315684738941854 no 1084 0.33361689852879 1591 723482 SGTC_763 3453-1109 128 µM 0.427582341389367 0.31663332875062 no 1085 0.33447761228985 1664 1560353 SGTC_1539 benzyladenosine 56 µM 0.427397190233659 0.316707636523206 no 1086 0.334545026799067 1550 92208 A nucleotide analog. SGTC_2760 etidronate 98.04 µM 0.427012688187106 0.316861974556807 no 1087 0.334685043056906 1555 3305 A chelator and antioxidant. SGTC_2585 alliin 100 µM 0.426620404467793 0.31701946898335 no 1088 0.334827916700896 1698 87310 A garlic compound which reacts with lipids. SGTC_3044 9093193 49.47 µM 0.426316690011516 0.317141427315233 no 1089 0.334938548960443 1533 25236277 SGTC_935 2996-0153 430 µM 0.425870119585406 0.317320786377548 no 1090 0.335101244529872 1711 23738523 SGTC_2065 5221596 34.26 µM 0.425645420955829 0.317411049818028 no 1091 0.335183118957724 1614 788581 SGTC_2030 5175110 200 µM 0.425471297452187 0.317481004248266 no 1092 0.335246570490158 1646 2831986 SGTC_1788 fluconazole 20 µM 0.425188667981147 0.31759456502282 no 1093 0.335349572182349 1559 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2151 5563267 85.4165 µM 0.425038141890059 0.317655053547386 no 1094 0.335404435074033 1586 5310824 SGTC_1064 honokiol 6.76 µM 0.424848887047834 0.317731112028955 no 1095 0.335473418581148 1589 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1942 st076330 65.2 µM 0.42308136129737 0.31844182327733 no 1096 0.336117950349923 1615 24208414 SGTC_837 0091-0265 12.5 µM 0.421299149192924 0.319159116932892 no 1097 0.336768325713892 1561 759367 SGTC_1264 0783-0040 158 µM 0.417970934896215 0.32050044861542 no 1098 0.337984183975045 1532 2855798 SGTC_1829 berberine 14.4 µM 0.416792119245338 0.320976097037471 no 1099 0.338415233623519 1703 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2197 6588183 93.1375 µM 0.416261953197601 0.321190113252623 no 1100 0.338609164992097 1594 884136 SGTC_1078 idebenone 36.1 µM 0.414954234389194 0.32171826402525 no 1101 0.339087703122298 1613 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1650 st011916 45.8 µM 0.414531171626131 0.321889204376368 no 1102 0.339242571603731 1691 242528 SGTC_1850 st056238 17 µM 0.414271177442504 0.321994274863767 no 1103 0.339337759858302 1564 5393177 SGTC_3282 9108498 15.4605 µM 0.411454390275691 0.32313352345438 no 1104 0.340369689291778 1581 16459645 SGTC_1413 3910-0535 34.4 µM 0.410766128824423 0.323412143474843 no 1105 0.340622015924487 1687 2876951 SGTC_936 3005-4620 401 µM 0.409967442695736 0.323735589458613 no 1106 0.340914915274203 1714 777207 SGTC_65 0798-0905 34.986 µM 0.409070629114988 0.324098933096269 no 1107 0.341243914873798 1802 3602145 SGTC_1980 st071811 45.7 µM 0.407913613096933 0.324567945237163 no 1108 0.341668549070813 1685 4974850 SGTC_749 1000-0129 128 µM 0.407643683979254 0.324677404739223 no 1109 0.341767644086926 1755 708470 SGTC_622 1348-1566 26.3 µM 0.407077485218588 0.324907054330834 no 1110 0.341975539538469 1699 7340407 SGTC_1974 st069448 26.9 µM 0.405899182591836 0.32538518586368 no 1111 0.342408339338585 1724 6323587 YNR016C ACC1 SGTC_653 0203-0016 55.2 µM 0.404914000867638 0.325785173579512 no 1112 0.342770363261998 1652 295302 SGTC_3297 9117502 71.43 µM 0.403120627687658 0.326513805025596 no 1113 0.343429743224763 1630 7453720 SGTC_532 1548-0774 215 µM 0.401787192447513 0.327055997356176 no 1114 0.343920324325568 1738 5932993 SGTC_342 k048-0088 23.3 µM 0.399485321182319 0.327992827507111 no 1115 0.344767818733575 1577 6820570 SGTC_1336 1486-0901 104 µM 0.399042399440839 0.328173215056475 no 1116 0.344930981577322 1659 5006114 SGTC_180 1486-1293 102.781 µM 0.399036674367158 0.328175546954324 no 1117 0.344933090760198 1797 4140536 SGTC_2159 5658611 73.75 µM 0.398891940618189 0.328234501139096 no 1118 0.344986413935602 1712 793844 SGTC_2994 9053520 71.4286 µM 0.398691505959488 0.328316150957983 no 1119 0.345060263665237 1733 4647384 SGTC_1695 st026914 34.495 µM 0.396642526583732 0.329151300805881 no 1120 0.34581554391664 1605 3289191 SGTC_2182 6325192 200 µM 0.396187900507714 0.329336719079828 no 1121 0.345983208292571 1634 736248 SGTC_1319 1306-0155 43.7 µM 0.390426921026095 0.331689945484751 no 1122 0.348110442086299 1669 3122360 SGTC_2073 5212005 126 µM 0.389926390415468 0.331894716272652 no 1123 0.348295489355862 1697 691789 SGTC_2843 9000894 45.46 µM 0.38653206675176 0.333284681820715 no 1124 0.349551329288666 1598 2242070 SGTC_849 0386-0493 241 µM 0.385701138289147 0.333625294632597 no 1125 0.349859009857982 1627 726119 SGTC_1914 st062367 72.6 µM 0.385595419698347 0.333668640463913 no 1126 0.349898162970786 1643 978205 SGTC_520 3584-0023 682 µM 0.385424290183993 0.333738810227487 no 1127 0.349961544545867 1614 1340790 SGTC_2489 cantharidin 73.42 µM 0.385391170292733 0.333752391344108 no 1128 0.349973811708083 1602 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2504 purpurogallin 52.29 µM 0.383959863427636 0.334339519805783 no 1129 0.350504097963349 1626 5281571 An antioxidant. SGTC_2265 7929201 200 µM 0.383421104747339 0.334560626140987 no 1130 0.350703778748236 1587 1265108 SGTC_2911 7942208 15.64 µM 0.382884011998469 0.334781105904752 no 1131 0.35090288314845 1621 1243384 SGTC_1513 0337-0559 19 µM 0.382569601230302 0.33491019983399 no 1132 0.351019456636039 1578 775073 SGTC_3312 9133330 71.43 µM 0.381462130710268 0.33536507150028 no 1133 0.351430183013824 1731 17617324 SGTC_2769 toremifene 3.73 µM 0.381407814845178 0.335387386887164 no 1134 0.351450331547323 1680 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1257 0669-0121 16 µM 0.38110604148307 0.335511379457927 no 1135 0.351562282328391 1764 4307855 SGTC_2014 4013930 200 µM 0.379966194600923 0.335979881030222 no 1136 0.351985254661436 1686 64556 SGTC_356 1634-0012 32.5 µM 0.377032445325463 0.337186886190059 no 1137 0.353074746640303 1811 735457 SGTC_939 1165-0479 45.3 µM 0.376900945839834 0.337241027178241 no 1138 0.353123609249282 1724 1377347 SGTC_478 N-arachidonylglycine 10 µM 0.376352146352507 0.337467015363793 no 1139 0.353327558424284 1706 5283389 SGTC_1400 3771-8998 51.5 µM 0.375728019484918 0.337724093602413 no 1140 0.353559552547882 1722 670767 SGTC_329 k048-0121 21.3 µM 0.37483840501192 0.338090657233332 no 1141 0.353890325067181 1632 6832902 SGTC_95 0471-0001 561.058 µM 0.374618573185986 0.338181262114088 no 1142 0.353972078971775 1580 4015405 SGTC_2077 5212015 200 µM 0.373951678613221 0.338456183659669 no 1143 0.35422013353742 1589 780900 SGTC_2125 5246583 200 µM 0.373640149267636 0.338584638472005 no 1144 0.354336029546061 1833 835267 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.370261552885205 0.33997895951169 no 1145 0.355593808827518 1617 23665772 A membrane-active detergent. SGTC_3261 9137475 49.47 µM 0.369095291403488 0.340460776600753 no 1146 0.356028349238924 1680 17027690 SGTC_1472 k841-0093 193 µM 0.369037626964903 0.340484606249786 no 1147 0.356049839440892 1754 X1472 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.367914226370493 0.34094897498788 no 1148 0.356468596012454 1665 6857784 SGTC_616 4092-0450 108 µM 0.36741578895062 0.341155086271331 no 1149 0.356654448024631 1709 787165 SGTC_2160 5660466 132.927 µM 0.367040205566851 0.341310426906146 no 1150 0.356794514028528 1775 2859134 SGTC_1280 0880-0253 10.1 µM 0.365392412751744 0.341992268662174 no 1151 0.357409252027967 1664 6836607 SGTC_1884 5633444 25 µM 0.361704341561028 0.343520224989334 no 1152 0.358786491168623 1720 5724239 SGTC_769 0302-0231 76 µM 0.361306664627585 0.343685134666535 no 1153 0.358935106053894 1729 571869 YER009W NTF2 SGTC_1957 st077035 62.4 µM 0.360998997339963 0.34381273933036 no 1154 0.359050098304931 1715 705593 SGTC_294 k038-0071 157 µM 0.35987479808373 0.344279150924572 no 1155 0.359470382161233 1700 24152826 SGTC_357 1325-0123 420 µM 0.359679397116455 0.344360243730051 no 1156 0.359543450516406 1794 1098503 SGTC_3330 9141424 71.43 µM 0.359624880823016 0.344382869660375 no 1157 0.359563837288327 1785 27261020 SGTC_1368 1852-0141 284 µM 0.358915007190379 0.344677539757503 no 1158 0.35982933626177 1693 2838987 SGTC_444 curcumin 90.4 µM 0.35882080125173 0.344716651937242 no 1159 0.359864575197596 1727 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1247 0448-0043 5.84 µM 0.358789002519361 0.344729854428014 no 1160 0.35987647018892 1690 3089013 YGL099W LSG1 SGTC_1987 st072290 61.9 µM 0.358762073894993 0.344741035050338 no 1161 0.359886543519019 1706 54697379 SGTC_2977 9011197 71.43 µM 0.357178658397304 0.345398698904243 no 1162 0.360479030846455 1748 2704722 SGTC_3183 9108214 49.47 µM 0.356340164229694 0.345747152616345 no 1163 0.36079291702389 1728 4974831 SGTC_3065 9113888 49.47 µM 0.355353420106045 0.346157382095331 no 1164 0.361162419972694 1768 16648368 SGTC_1374 2889-5571 141 µM 0.354656150637315 0.346447374166772 no 1165 0.361423602420945 1669 2853281 SGTC_3077 9117319 49.47 µM 0.353815539534014 0.346797101231093 no 1166 0.361738563494552 1713 17154678 SGTC_1656 st012921 11 µM 0.353611695941106 0.346881927813155 no 1167 0.361814953953229 1769 6732821 SGTC_2963 9082507 9 µM 0.353130672753765 0.347082129118747 no 1168 0.361995239386778 1740 16459611 SGTC_934 2950-0684 338 µM 0.352898513018891 0.347178769014029 no 1169 0.362082262822681 1821 1121253 SGTC_1094 duloxetine 25.4 µM 0.352233162850314 0.347455785817872 no 1170 0.362331704115194 1711 60834 A selective serotonin reuptake inhibitor. SGTC_1361 1608-0041 5.61 µM 0.352144818385802 0.347492573936543 no 1171 0.362364829054986 1671 X1361 SGTC_3137 9097352 49.47 µM 0.351338649345003 0.347828342588296 no 1172 0.362667151385552 1765 44120435 SGTC_2589 lobaric acid 100 µM 0.349089297570379 0.348765826009871 no 1173 0.363511135541424 1644 73157 A novel microtubule depolymerizer. SGTC_910 3454-3003 490 µM 0.348785848479502 0.348892368201365 no 1174 0.363625044167894 1783 820824 SGTC_2940 9060638 45.86 µM 0.348496967143899 0.349012851068848 no 1175 0.363733495557277 1719 4027022 SGTC_1304 1165-0502 251 µM 0.348138199507406 0.349162502396486 no 1176 0.363868198754562 1734 767425 SGTC_2143 5623677 140.463 µM 0.348107983880766 0.34917510719286 no 1177 0.363879544307462 1748 5375313 SGTC_1161 k007-0610 110 µM 0.346430058093902 0.349875334052206 no 1178 0.3645097694572 1755 5843850 SGTC_473 2-arachidonoylglycerol 10 µM 0.345505973177256 0.350261188667253 no 1179 0.364857010251193 1672 5282280 An endocannabinoid. SGTC_591 4299-0174 154 µM 0.345465887680406 0.350277929996386 no 1180 0.364872075576968 1742 5509088 SGTC_2742 clothiapine 36.27 µM 0.345386244104564 0.350311193246742 no 1181 0.364902008628172 1806 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1220 1838-0075 193 µM 0.343807340426213 0.350970861277136 no 1182 0.365495589763568 1748 5529645 SGTC_2784 7567673 72.73 µM 0.343695101342664 0.351017772045955 no 1183 0.365537797785074 1671 3471247 SGTC_2355 9061122 103.12 µM 0.343488903200348 0.351103959292064 no 1184 0.365615343784063 1823 5302957 SGTC_393 acivicin 6.25 µM 0.342587790617674 0.351480698544746 no 1185 0.365954294252548 1710 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2338 7999974 200 µM 0.342509594490562 0.351513397851144 no 1186 0.365983712401174 1892 315925 SGTC_2057 5236571 38.335 µM 0.342169645029318 0.351655567425931 no 1187 0.366111613873247 1825 54684039 YBR257W POP4 SGTC_3050 9093513 49.47 µM 0.341544823163201 0.351916927016857 no 1188 0.366346733600735 1699 25236664 SGTC_940 3232-1287 54.8 µM 0.341464116883411 0.351950691121291 no 1189 0.366377106939332 1817 1585493 YIL048W NEO1 SGTC_750 4073-0104 132 µM 0.341310526906523 0.352014949916105 no 1190 0.366434911945169 1686 22330957 SGTC_2391 6285546 200 µM 0.341205968102147 0.352058697524398 no 1191 0.36647426535028 1672 846083 SGTC_32 0928-0142 34.1 µM 0.341063244644233 0.352118416459048 no 1192 0.366527985274092 1798 2244242 SGTC_834 0312-0008 75.7 µM 0.340017228103601 0.352556206224586 no 1193 0.366921776961738 1709 6385573 YIL048W NEO1 SGTC_412 gemfibrozil 100 µM 0.339994796276382 0.352565596768986 no 1194 0.366930223361028 1744 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_390 dec-rvkr-cmk 16.7 µM 0.33986793295021 0.352618706737006 no 1195 0.36697799323241 1758 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2165 5727197 32.143 µM 0.33886932088795 0.353036865182444 no 1196 0.36735408842184 1769 1361712 SGTC_2451 5856223 45.7 µM 0.338863296070591 0.353039388551541 no 1197 0.36735635786261 1675 2179896 SGTC_599 1935-0052 86.5 µM 0.338704075913276 0.353106076935674 no 1198 0.36741633492254 1724 9557311 SGTC_1298 1079-1278 263 µM 0.338568806948507 0.353162737054959 no 1199 0.367467292286097 1731 2840950 SGTC_2483 5729050 27.16 µM 0.338134068870474 0.35334485785762 no 1200 0.36763107888304 1845 2865180 SGTC_2136 5328288 199.296 µM 0.337824331529698 0.353474633749399 no 1201 0.367747786422639 1681 262395 SGTC_911 3456-4043 236 µM 0.337573692153846 0.353579660838318 no 1202 0.367842235073492 1790 914281 SGTC_3352 9151559 45.5865 µM 0.337136905608762 0.353762717054258 no 1203 0.368006848817054 1679 17159339 SGTC_493 zm226600 134 µM 0.335285117159903 0.354539172397275 no 1204 0.3687050097214 1762 5240098 A potassium channel opener. YCR052W RSC6 SGTC_628 1636-0253 16 µM 0.333901072958744 0.355119897654458 no 1205 0.369227105053214 1810 4456143 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.333088159653998 0.355461141551852 no 1206 0.369533868396152 1731 88881 An O-methylated flavonoid and antioxidant. SGTC_82 0054-0107 293.755 µM 0.332364142047381 0.355765166503572 no 1207 0.369807155747937 1843 3104697 SGTC_2475 5812728 15.03 µM 0.330888670737067 0.356385021086032 no 1208 0.37036428992288 1686 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1499 4480-0877 67.3 µM 0.328445561735949 0.357412220256043 no 1209 0.371287399300109 1772 2861909 SGTC_865 0488-0499 301 µM 0.32799965623216 0.357599811924267 no 1210 0.371455961272953 1826 9634651 SGTC_1347 1493-0251 600 nM 0.327551586576571 0.357788348706227 no 1211 0.371625366177099 1847 3986378 SGTC_1973 st070275 50.2 µM 0.326553632558107 0.358208388066226 no 1212 0.372002759117391 1816 17118334 SGTC_3052 9092717 49.47 µM 0.325512720609299 0.358646691353584 no 1213 0.372396528373006 1717 25237534 SGTC_132 0417-1715 25.805 µM 0.325276419281359 0.358746218186367 no 1214 0.372485938008463 1888 6769098 SGTC_1607 st000305 50.6 µM 0.324500214026971 0.359073212515583 no 1215 0.372779680123737 1810 5457690 SGTC_1795 st049545 62.3 µM 0.323834652000947 0.359353678095066 no 1216 0.373031610061371 1883 5291882 SGTC_930 2810-3379 265 µM 0.321713503126781 0.360248028098414 no 1217 0.373834873629136 1887 1015764 SGTC_1119 parthenolide 318.541 nM 0.321687285794623 0.360259087033873 no 1218 0.373844805378377 1816 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1460 k062-0059 9.15 µM 0.321649895266724 0.360274859223653 no 1219 0.373858969944934 1677 1373085 SGTC_259 usnic acid 108.925 µM 0.321623935750093 0.360285809688264 no 1220 0.373868804228324 1821 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_277 nystatin 15.5 µM 0.321422686610826 0.360370706203804 no 1221 0.37394504653275 1692 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1326 1431-2094 10.8 µM 0.320989686602433 0.360553389660998 no 1222 0.374109103298411 1695 616278 SGTC_583 1488-1091 88.9 µM 0.319814614680563 0.361049314855417 no 1223 0.374554434055712 1889 4303273 SGTC_899 1083-0020 478 µM 0.319689091145157 0.361102304405399 no 1224 0.374602015084009 1862 767123 SGTC_2707 st078556 66.6 µM 0.317908474660559 0.361854275333309 no 1225 0.375277181997203 1891 17250899 SGTC_107 0358-0022 2.6945 µM 0.316883183532725 0.362287507647162 no 1226 0.375666121281385 1841 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2083 5306046 65.942 µM 0.316747196123244 0.362344981801748 no 1227 0.375717716955704 1728 539837 SGTC_2880 9042983 58.44 µM 0.316524335023206 0.362439179240433 no 1228 0.375802278623832 1741 6464714 SGTC_1265 0819-1001 68.8 µM 0.31650510683026 0.362447306874751 no 1229 0.375809574784451 1738 3106768 SGTC_22 0964-0034 14.468 µM 0.316067005142991 0.36263250645075 no 1230 0.375975825015805 1739 138402 SGTC_1502 4534-4282 27.7 µM 0.314527591378239 0.363283520471425 no 1231 0.376560182038004 1775 3278949 SGTC_1459 k035-0031 35.7 µM 0.314261186663081 0.363396222481084 no 1232 0.37666133725977 1661 3877128 YMR208W ERG12 SGTC_695 3505-6186 243 µM 0.313358363309066 0.363778248081814 no 1233 0.377004206812392 1798 1819379 SGTC_779 1360-0071 233 µM 0.312122375118829 0.364301470477305 no 1234 0.377473761242146 1914 7566 SGTC_3165 9101544 49.47 µM 0.31202482561541 0.364342776222645 no 1235 0.377510828219574 1831 5002184 SGTC_3231 9132313 49.47 µM 0.311619742546764 0.364514318888204 no 1236 0.377664764237187 1782 4905967 SGTC_874 0599-0792 117 µM 0.31149396633666 0.364567587526409 no 1237 0.377712564533904 1915 765305 SGTC_1111 tnp00062 510.699 nM 0.310590758643532 0.364950190078612 no 1238 0.378055876752316 1876 676306 SGTC_2474 5321570 43.32 µM 0.307840156384589 0.366116183799936 no 1239 0.379101981992974 1869 2841384 SGTC_1163 k060-0048 49.9 µM 0.307757434347108 0.366151269294972 no 1240 0.379133456485566 1756 6809982 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.307554406385172 0.366237385753834 no 1241 0.379210708971502 1900 756377 SGTC_2210 7115885 190.385 µM 0.307245639722817 0.366368365314594 no 1242 0.379328204459137 1794 2927039 SGTC_350 k064-0020 19.8 µM 0.307117324575346 0.366422801488816 no 1243 0.379377035713311 1890 2790705 SGTC_491 tetrandrine 80.3 µM 0.306191960968493 0.366815455506097 no 1244 0.379729246438741 1866 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_209 4077-0173 175.592 µM 0.304363580442991 0.367591690775832 no 1245 0.380425455490619 1800 15993494 SGTC_2861 9024595 19.48 µM 0.30384784245627 0.367810744305166 no 1246 0.380621907892768 1850 16482810 SGTC_1863 st057641 20.1 µM 0.303772961518777 0.367842552662753 no 1247 0.380650433735485 1918 3921635 SGTC_1155 4088-0394 48.2 µM 0.303752535066481 0.367851229686615 no 1248 0.380658215291384 1741 2326248 SGTC_2933 9026794 32.47 µM 0.303396669278123 0.368002409973607 no 1249 0.380793791831594 1815 17586027 SGTC_1772 st048439 82.2 µM 0.302943713966366 0.368194865782989 no 1250 0.380966378381213 1776 2927068 YDL195W SEC31 SGTC_536 3852-0578 10.6 µM 0.302885322506332 0.368219678090551 no 1251 0.380988628614889 1890 2869208 SGTC_1510 1123-0200 71.5 µM 0.298389316497403 0.370131811138604 no 1252 0.38270302104694 1884 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1588 farnesol 29.9 µM 0.297547851891991 0.370490041114158 no 1253 0.383024140362224 1768 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_866 0495-0101 262 µM 0.297339192184954 0.37057888953032 no 1254 0.383103781428655 1698 635694 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.29691138222973 0.37076107487228 no 1255 0.383267083030446 1833 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_730 1436-0052 41.2 µM 0.29586326800311 0.3712075427724 no 1256 0.383667251869469 1804 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.295526801410467 0.371350905101163 no 1257 0.383795740773538 2007 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1682 st012968 530 nM 0.294631723715982 0.371732368372789 no 1258 0.384137612663014 1711 24207270 SGTC_1630 st005209 31.3 µM 0.294523815347569 0.371778365164163 no 1259 0.384178833993869 1939 3367314 SGTC_440 fluspirilene 35.1 µM 0.293497725803629 0.372215835276377 no 1260 0.384570868772491 1864 3396 An atypical antipsychotic. SGTC_1860 st056228 74.6 µM 0.292939782577029 0.372453781927992 no 1261 0.38478408995635 1753 688679 SGTC_957 1187-1561 14.1 µM 0.291749897728229 0.372961395962437 no 1262 0.385238927576186 1831 1538454 SGTC_580 1123-0028 41 µM 0.291676118756942 0.372992877912923 no 1263 0.385267135050124 1828 1677248 YPR107C YTH1 SGTC_2539 epi(13)torulosol 80 µM 0.291317294846178 0.373146002419365 no 1264 0.385404330707874 1733 6708597 SGTC_745 0469-0705 296 µM 0.289003341193696 0.374133939253986 no 1265 0.386289410353289 1916 3486736 SGTC_2354 9060492 162 µM 0.288872905383444 0.374189653192046 no 1266 0.386339319289888 1895 6471895 SGTC_3059 1327-0034 3 µM 0.287853157522423 0.374625315550432 no 1267 0.386729572384334 1757 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_110 0850-0284 111.64 µM 0.287013976098716 0.374983955416013 no 1268 0.387050809437296 1856 3906265 SGTC_1703 st026983 48.3 µM 0.285351820575504 0.375694627556605 no 1269 0.387687307632463 1918 1104023 SGTC_1130 3454-2858 15.9 µM 0.284397059249288 0.376103036789157 no 1270 0.388053056190603 1728 715628 YIL048W NEO1 SGTC_218 alverine citrate 93.75 µM 0.283962536185134 0.376288954600629 no 1271 0.388219545551057 1875 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1312 1218-2183 165 µM 0.282457231583108 0.376933245580413 no 1272 0.388796468090751 1874 6744073 SGTC_3179 9107801 49.47 µM 0.282350868976152 0.376978783221443 no 1273 0.388837241882639 1767 4818259 SGTC_3126 9127922 49.47 µM 0.279785923992184 0.378077444856329 no 1274 0.389820875808438 1851 45595682 SGTC_2571 chrysanthemic acid 100 µM 0.279461379794443 0.378216529751374 no 1275 0.389945386115343 1733 2743 An insecticide. SGTC_1498 4478-3555 97.6 µM 0.279354610533245 0.378262289655916 no 1276 0.389986350258261 1935 3437919 SGTC_2353 9059630 146.67 µM 0.278253980286287 0.378734104760079 no 1277 0.390408700002737 1889 4779114 SGTC_1445 4239-0156 97.7 µM 0.277406749576902 0.379097416443752 no 1278 0.390733899757993 1941 4008346 SGTC_1616 st002734 56.1 µM 0.277369750146203 0.379113285072942 no 1279 0.390748103307124 1853 4026101 SGTC_152 4469-0003 551.229 µM 0.27638118125393 0.379537346229193 no 1280 0.391127654601739 1958 697280 SGTC_2425 5628681 7.85 µM 0.275774024753603 0.379797866817221 no 1281 0.391360817796456 1913 5714958 SGTC_871 0574-0004 149 µM 0.275301247120219 0.380000765499831 no 1282 0.391542403206547 1823 9551173 SGTC_2522 biochanin a 4.94 µM 0.273781451052022 0.380653229306232 no 1283 0.39212628954667 1875 5280373 A possible chelator. SGTC_3100 9120536 49.47 µM 0.273549416654722 0.380752873945081 no 1284 0.392215455627256 1937 16421196 SGTC_2342 7990637 118.86 µM 0.27346601396108 0.380788692254367 no 1285 0.392247506962317 1834 2033102 YER133W GLC7 SGTC_2078 5212016 200 µM 0.272610130935512 0.381156320702476 no 1286 0.392576461730463 1951 1899708 SGTC_1925 st057770 10.1 µM 0.271053670909298 0.381825143556563 no 1287 0.393174876668619 1699 5989122 SGTC_2600 tangeritin 87.95 µM 0.270086671307663 0.382240848598777 no 1288 0.393546787976225 1754 68077 A bioactive flavone. SGTC_2341 7987486 176.74 µM 0.269814717890878 0.382357783580497 no 1289 0.393651399693479 1978 1258686 SGTC_734 2023-0417 80 µM 0.269713252706119 0.382401414497944 no 1290 0.393690432047592 1890 3935732 SGTC_1668 st014914 51.6 µM 0.269237002026674 0.382606226399836 no 1291 0.393873653838101 1866 2839556 SGTC_1202 1988-0068 29.6 µM 0.268831473832677 0.382780649941049 no 1292 0.394029685999678 1754 2850480 SGTC_2185 6113692 200 µM 0.268686965358567 0.382842810873464 no 1293 0.394085291596426 1848 874150 SGTC_3086 9117350 49.47 µM 0.265760331805161 0.384102362051615 no 1294 0.395211897740161 1831 2679265 SGTC_2145 5634607 200 µM 0.265664926058838 0.384143443030762 no 1295 0.395248638937783 1784 308662 SGTC_3227 9130768 49.47 µM 0.265116547215814 0.38437959596383 no 1296 0.395459840236509 1892 17720899 SGTC_1956 st077085 54 µM 0.264446605670227 0.384668156691685 no 1297 0.395717901566801 1806 24208685 SGTC_2122 5258151 111.688 µM 0.264111469518135 0.384812532279665 no 1298 0.395847013100225 1816 2173356 SGTC_2644 guaiazulene 100 µM 0.263250298839121 0.385183595084677 no 1299 0.39617883233662 1945 3515 A coloring agent. SGTC_925 2064-1272 59.6 µM 0.262376931308967 0.385560020690681 no 1300 0.396515428001679 1789 6815817 SGTC_629 3448-6466 76.7 µM 0.26237184081792 0.385562215033186 no 1301 0.396517390102224 1851 573744 SGTC_1219 1469-0211 33.1 µM 0.262231552380901 0.38562269018461 no 1302 0.396571464505876 1942 6822282 SGTC_1509 1326-1131 80 µM 0.26196851017357 0.38573608918532 no 1303 0.396672859908829 1952 768313 SGTC_523 1934-0222 13.7 µM 0.260990811216771 0.386157666340767 no 1304 0.39704979666985 1795 1361595 SGTC_3311 9131146 2.8755 µM 0.260955873611913 0.386172733689906 no 1305 0.397063268106985 1849 4900406 YPR165W RHO1 SGTC_2652 actinonin 100 µM 0.260360563165709 0.38642949632604 no 1306 0.397292830102831 1890 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2666 tannic acid 100 µM 0.259936506265764 0.386612426139518 no 1307 0.397456375477699 1883 16134267 A thiamine antagonist. SGTC_398 bronopol 33.3 µM 0.257539532796688 0.387646906050866 no 1308 0.398381150721245 1859 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_738 1315-0003 72.4 µM 0.257496194855806 0.387665617099837 no 1309 0.398397876183192 1937 6251474 SGTC_3105 9121040 49.47 µM 0.256661309955342 0.388026127468271 no 1310 0.398720120681458 1975 41448907 SGTC_3246 9135460 32.98 µM 0.253958865112394 0.389193726433969 no 1311 0.399763668657556 1923 41446951 SGTC_1054 3429-0080 167 µM 0.253712134509892 0.389300377128413 no 1312 0.399858979378128 1919 1162877 SGTC_2036 5160441 105 µM 0.252491125245974 0.38982828787531 no 1313 0.400330736486568 1894 134534 YIL048W NEO1 SGTC_2950 9072895 21.46 µM 0.252272043693194 0.389923030650442 no 1314 0.400415397675657 1791 17332245 SGTC_1574 spiramycin 23.7 µM 0.251515842726983 0.39025010327801 no 1315 0.400707657534582 1852 6419898 An antibiotic and protein synthesis inhibitor. SGTC_221 trifluoperazine 10.304 µM 0.251015005348479 0.390466768635552 no 1316 0.40090125396852 1871 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2158 5657123 3.6195 µM 0.247437925025512 0.392015221173088 no 1317 0.402284663278185 1971 2858827 SGTC_2067 5224629 34.075 µM 0.246453746286664 0.392441555444443 no 1318 0.402665502704006 1809 2835000 SGTC_2201 6605497 169.863 µM 0.243081222941424 0.393903467944718 no 1319 0.403971238475965 1962 670741 SGTC_3228 9131799 49.47 µM 0.241234040831583 0.39470481517234 no 1320 0.404686864520677 1900 17015818 SGTC_609 0986-0026 86.3 µM 0.241146712950549 0.394742710941023 no 1321 0.404720704565178 1908 2848610 SGTC_1909 st060837 51.5 µM 0.241041397789153 0.394788413580729 no 1322 0.404761515729782 1838 678937 SGTC_1636 st007707 68.9 µM 0.239965987387184 0.395255182190709 no 1323 0.405178312209863 1970 403051 SGTC_1939 st074455 53.6 µM 0.239657104743713 0.395389276708377 no 1324 0.405298045667317 2025 1644229 SGTC_2127 5253358 187.912 µM 0.239242800228166 0.395569157230564 no 1325 0.405458658157169 1835 20612 SGTC_646 4092-0839 27.3 µM 0.238702692300758 0.395803691809579 no 1326 0.40566806447179 1959 877796 SGTC_2 0422-0095 29 µM 0.238407815299193 0.395931754096808 no 1327 0.405782403216175 1897 6790840 SGTC_3340 9146634 11.102 µM 0.238338610378354 0.395961810766138 no 1328 0.405809238633118 1868 4907387 SGTC_2770 toltrazuril 17.5 µM 0.237975087903428 0.396119703838466 no 1329 0.405950208089217 1995 68591 Kills coccidiodes. SGTC_555 4296-0685 37 µM 0.236356910767385 0.39682275254525 no 1330 0.406577864611768 1923 2908540 YHR072W ERG7 SGTC_2144 5628481 200 µM 0.23624970358605 0.396869342677092 no 1331 0.406619456496775 1876 2818399 SGTC_2752 diclazuril 33.15 µM 0.236024457782933 0.396967234866601 no 1332 0.406706845842133 2006 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1828 st055811 49 µM 0.235511056202714 0.397190384276473 no 1333 0.406906049276378 2011 5877589 SGTC_793 0488-0545 106 µM 0.235090254325538 0.397373310435335 no 1334 0.407069341337423 1843 292548 SGTC_2767 sibutramine 71.45 µM 0.23468150410679 0.397551019249999 no 1335 0.407227972223063 2005 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2909 7941780 10.49 µM 0.234466821106714 0.397644363649804 no 1336 0.407311294127077 2034 1243215 SGTC_2913 7966556 36.57 µM 0.234466041405302 0.397644702675503 no 1337 0.407311596749305 1973 2976516 SGTC_1416 3966-0321 25.3 µM 0.234324084802147 0.397706428792948 no 1338 0.407366694690055 1906 582530 YLR208W SEC13 SGTC_2693 st077581 40.7 µM 0.233636841675778 0.398005294684157 no 1339 0.407633461830566 2024 25238761 SGTC_1406 3909-7906 11.9 µM 0.233598248979153 0.398022079517954 no 1340 0.407648443627703 1949 X1406 SGTC_178 4092-0806 87.505 µM 0.233119027537946 0.398230519439216 no 1341 0.407834490030551 1938 2169044 SGTC_83 0170-0301 39.027 µM 0.229289510613931 0.39989722689058 no 1342 0.409321952826692 1997 3089716 SGTC_23 0213-0011 39.996 µM 0.229273731434018 0.399904098205396 no 1343 0.409328084500595 1995 627608 SGTC_3233 9132340 49.47 µM 0.227762046561472 0.400562530758023 no 1344 0.409915616834621 1863 17682950 SGTC_2854 9024559 71.43 µM 0.226265642931335 0.401214585792347 no 1345 0.410497409223431 1846 3163529 SGTC_985 1493-0307 8.71 µM 0.225336724267159 0.401619498911635 no 1346 0.410858666191633 2022 3278274 SGTC_1742 st038235 28.8875 µM 0.225074692498884 0.40173373696963 no 1347 0.410960584175276 1884 564103 YBR002C RER2 SGTC_2563 tomatine 8.54 µM 0.224581170919826 0.401948920495594 no 1348 0.411152557080261 2127 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3175 9106517 49.47 µM 0.224464506984526 0.401999792236706 no 1349 0.411197940810112 1891 41468073 SGTC_1952 st077036 64.1 µM 0.223709743185544 0.402328949867433 no 1350 0.411491582057633 2045 2937007 SGTC_2094 5332512 191.667 µM 0.22353869500116 0.40240355478084 no 1351 0.41155813534009 1990 755774 SGTC_595 3909-8003 73.7 µM 0.223096919189394 0.402596257547957 no 1352 0.411730038032993 1940 699517 SGTC_617 3770-0098 35 µM 0.220982899482463 0.403518720543008 no 1353 0.412552874039352 1904 5962639 SGTC_3301 9125354 19.7965 µM 0.220973211440319 0.403522949208328 no 1354 0.412556645785912 1869 41905162 SGTC_2005 4024620 188 µM 0.220839813970117 0.403581176077735 no 1355 0.412608580882253 1920 236743 SGTC_731 3966-0296 387 µM 0.220149084594414 0.403882707773815 no 1356 0.412877524202588 1910 660956 SGTC_795 0685-0265 78 µM 0.218995203368889 0.404386551588585 no 1357 0.413326892120461 1949 302754 SGTC_2630 antimycin a 100 µM 0.218980368916439 0.404393030107003 no 1358 0.413332669995561 1901 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_782 0083-0095 30.5 µM 0.217720544097292 0.404943317667446 no 1359 0.413823427880793 1915 3591729 An indicator and reagent. SGTC_206 4546-0025 72.014 µM 0.217066477692404 0.405229086055189 no 1360 0.414078269018938 1923 6620745 YIL048W NEO1 SGTC_967 1306-0166 352 µM 0.216578810040613 0.405442185998244 no 1361 0.414268300464292 2040 4437607 SGTC_1708 st033234 31.827 µM 0.215620171791582 0.405861171299696 no 1362 0.414641915414498 2004 674664 SGTC_830 4076-0286 57.8 µM 0.215350852879127 0.405978900057336 no 1363 0.414746892352342 1928 6866659 SGTC_1171 0368-0077 21.4 µM 0.21432234592719 0.406428574729009 no 1364 0.415147846674464 1902 3239779 SGTC_2019 4016004 108 µM 0.213940262980184 0.406595657116895 no 1365 0.415296820865589 1863 45595336 SGTC_1773 st048542 73.5835 µM 0.213708145059429 0.406697169079804 no 1366 0.415387329621026 1852 3237138 SGTC_2303 7774051 200 µM 0.211863463189747 0.407504124837427 no 1367 0.416106777832657 2012 2953184 SGTC_3084 9116877 49.47 µM 0.210593468376064 0.408059912282334 no 1368 0.416602254748926 2048 27241325 SGTC_2568 diosmetin 100 µM 0.206846277800758 0.409700868571921 no 1369 0.418064956578603 2080 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1291 0993-0025 5.79 µM 0.2067113769878 0.409759973544997 no 1370 0.418117635874647 2018 4353356 SGTC_3020 9089140 49.47 µM 0.203923587293723 0.410981863201492 no 1371 0.419206606184499 1916 17217859 SGTC_104 0074-0074 590.992 µM 0.203822360674566 0.411026247211917 no 1372 0.419246159168059 2055 3943124 SGTC_1955 wogonin 32.4 µM 0.203270457870043 0.411268255555386 no 1373 0.41946182234752 2029 5281703 A flavanone. SGTC_280 3448-3607 3.04 µM 0.202718683008069 0.411510241554645 no 1374 0.419677459719007 2057 626179 SGTC_3177 9107506 49.47 µM 0.200162269528 0.412631818373086 no 1375 0.420676837277455 2063 8897194 SGTC_888 0916-0002 6.97 µM 0.199338470416925 0.412993396747063 no 1376 0.420998993965957 2024 2802138 YIL048W NEO1 SGTC_1836 st055642 81 µM 0.198996151275291 0.413143667726599 no 1377 0.421132877613101 1864 8571 SGTC_875 0709-0210 25.7 µM 0.198885236520347 0.413192359726662 no 1378 0.421176259183219 2098 6251364 SGTC_1605 st000082 49.1 µM 0.198227359426788 0.413481197702201 no 1379 0.421433591233069 2013 1114022 SGTC_1293 1000-1278 195 µM 0.198199419651802 0.413493465572252 no 1380 0.421444520765176 2013 678847 SGTC_1465 k213-0056 144 µM 0.197792269928683 0.413672247521792 no 1381 0.421603797199095 1931 24048857 YMR208W ERG12 SGTC_1018 4259-0013 28.1 µM 0.196987715858617 0.414025584757479 no 1382 0.42191857538213 1952 6801262 SGTC_551 k048-0028 34.9 µM 0.196367320136234 0.4142980924381 no 1383 0.422161336514295 2028 6836383 SGTC_3017 9080681 49.47 µM 0.196311417068053 0.414322649786494 no 1384 0.422183212864598 1925 16451914 SGTC_3135 9127742 49.47 µM 0.195996141513359 0.414461151702554 no 1385 0.422306593027423 1913 3643468 SGTC_2619 obliquin 87.91 µM 0.195885636363955 0.41450969961135 no 1386 0.422349839997337 2012 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1131 3454-3128 32.3 µM 0.195535875550079 0.414663367626727 no 1387 0.422486727527895 1995 710982 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.195520763139557 0.414670007584807 no 1388 0.422492642354012 2027 23847180 SGTC_1376 2910-0861 41.3 µM 0.194895875141303 0.414944586705559 no 1389 0.422737231717775 1992 1112859 SGTC_358 0075-0058 9.45 µM 0.192975488150716 0.415788674524952 no 1390 0.423489082440262 2173 1069125 SGTC_1358 1509-0022 2.48 µM 0.191313380307999 0.416519552137848 no 1391 0.424140039366678 1983 3258434 SGTC_524 r073-0010 27.8 µM 0.190374985495596 0.416932319562118 no 1392 0.42450764894612 1889 2772106 SGTC_572 0960-0087 17.7 µM 0.190112160095164 0.417047943803741 no 1393 0.424610620738523 1933 6796365 SGTC_2813 7971799 71.43 µM 0.18983940466812 0.41716794412835 no 1394 0.424717488434895 1967 2234054 SGTC_1045 1348-1485 165 µM 0.188920004775581 0.417572496199419 no 1395 0.42507775717853 2076 6810614 SGTC_2413 inermin 26.06 µM 0.188759915524739 0.417642947208104 no 1396 0.425140494887006 2087 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1571 st070080 73.4 µM 0.188087059640894 0.417939082011959 no 1397 0.425404202486083 2037 4315245 SGTC_2664 lyso-paf C-16 73.48 µM 0.188083989590419 0.417940433297812 no 1398 0.425405405785608 2015 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1493 4348-0038 111 µM 0.18763078825055 0.418139920949387 no 1399 0.425583044669045 2006 800424 SGTC_1670 st016595 4.04 µM 0.186035410178252 0.418842332852927 no 1400 0.426208496353608 2109 597879 SGTC_2456 5770359 74.46 µM 0.185382326310232 0.419129946930286 no 1401 0.426464584860235 2059 3118787 SGTC_1793 st048256 72.231 µM 0.185273778562771 0.419177754876757 no 1402 0.426507151820331 2073 672022 SGTC_1937 st074714 47.2 µM 0.184979799819995 0.419307238634605 no 1403 0.426622439775943 1850 17250970 SGTC_821 1114-0266 29.2 µM 0.182916234573839 0.42021638691287 no 1404 0.4274318722289 1965 3123235 SGTC_2723 salbutamol 83.58 µM 0.182186147515563 0.420538144786955 no 1405 0.427718321873914 2069 9884233 β2-adrenoceptor agonist SGTC_2084 5306078 60.6385 µM 0.180892581348953 0.421108364728918 no 1406 0.428225946009136 2022 679340 SGTC_194 1486-1323 56.904 µM 0.180619444428208 0.42122878806239 no 1407 0.428333146229721 1942 5178754 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.179682910327987 0.421641752455554 no 1408 0.428700755328386 2129 6708630 An antioxidant. SGTC_758 0868-0029 16 µM 0.178186438862943 0.422301799761741 no 1409 0.429288279757663 2115 762687 SGTC_546 peri-Naphthalide 147 µM 0.177644873434449 0.422540721416207 no 1410 0.429500940545734 2046 223824 A penicillin ester. SGTC_2286 7945697 125 µM 0.176964318924037 0.422841001088876 no 1411 0.429768208281204 1931 1245733 SGTC_3042 9091578 49.47 µM 0.175305537008143 0.423573089526846 no 1412 0.430419780620682 2089 25236497 SGTC_1174 0739-0097 51.1 µM 0.172266818184639 0.424914883457146 no 1413 0.431613884799209 2002 728447 SGTC_1526 st051518 75 µM 0.170736229842584 0.425591069337759 no 1414 0.432215586893863 1952 673993 SGTC_913 3487-1245 167 µM 0.169642772619628 0.426074272870722 no 1415 0.432645541185804 1990 4016153 SGTC_2179 6298986 200 µM 0.164830740346533 0.428202040723218 no 1416 0.434538603836165 2114 738374 SGTC_149 3970-0822 46.1 µM 0.164490788027882 0.428352439400215 no 1417 0.434672399032737 2046 3114250 YBL034C STU1 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.164332519742567 0.428422462597126 no 1418 0.434734691310843 2120 688662 SGTC_2056 5235370 200 µM 0.163962078326135 0.428586367108935 no 1419 0.434880498423973 1991 5511916 SGTC_3327 9140648 26.9345 µM 0.162704147830757 0.429143039421309 no 1420 0.435375690507756 2113 8029710 SGTC_1222 0366-0074 1.18 µM 0.161814422884002 0.429536854808287 no 1421 0.435725997455327 2126 286520 SGTC_2352 9027995 87.8 µM 0.161143936018422 0.429833676083355 no 1422 0.435990018231953 2038 2997347 SGTC_804 1595-0054 20.9 µM 0.160907417835167 0.429938391005241 no 1423 0.43608315992548 1976 761523 Stimulates phospholipase C. SGTC_1309 pyrazolanthrone 13.4 µM 0.16006675761321 0.43031062070543 no 1424 0.436414243537273 2136 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3149 9097855 49.47 µM 0.15942673532719 0.43059405296911 no 1425 0.436666338268972 2118 25236625 YMR079W SEC14 SGTC_1691 st019933 84.6 µM 0.159089541082555 0.430743392985792 no 1426 0.436799164141692 2152 6176082 SGTC_426 0988-0037 14.6 µM 0.156708481594311 0.431798221530978 no 1427 0.437737301164702 2184 5383008 SGTC_1570 verbenone 133 µM 0.155563030427155 0.432305839398693 no 1428 0.438188733771743 2139 29025 A natural terpanoid with antifungal properties. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.153310896824848 0.433304219528158 no 1429 0.439076553919527 1998 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1370 2001-0092 44.6 µM 0.152637569812962 0.433602791141996 no 1430 0.439342047856381 2122 790957 SGTC_2116 5511452 16.8835 µM 0.151777542363681 0.433984205925861 no 1431 0.4396811977498 2067 870744 SGTC_1305 1181-0477 144 µM 0.150618808918731 0.43449819139681 no 1432 0.440138211645948 2132 6252086 SGTC_2565 isoliquiritigenin 100 µM 0.149402182138091 0.435037976079524 no 1433 0.440618144979806 1861 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_534 k292-0788 63.4 µM 0.149290184906219 0.435087672350242 no 1434 0.440662329896545 2190 4146317 SGTC_2586 curcumin 80 µM 0.148993347371291 0.435219392336251 no 1435 0.440779441200529 2114 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_88 0180-0332 8.668 µM 0.148758291141126 0.435323702316693 no 1436 0.440872181603357 2135 3101745 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.146356500681992 0.436389792121776 no 1437 0.441819982449203 1988 6708561 SGTC_1976 st070609 63.5 µM 0.145135685446587 0.436931856658854 no 1438 0.442301871828655 2144 682556 SGTC_542 3381-0244 89.3 µM 0.144734023020297 0.437110228145197 no 1439 0.442460437748427 2165 1112843 SGTC_2715 st079500 56.4 µM 0.143942702759179 0.437461677453104 no 1440 0.442772857433034 2045 28246688 SGTC_1801 st050089 28.441 µM 0.143499870005665 0.437658374451513 no 1441 0.442947706953665 2128 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.143076647359627 0.437846375451673 no 1442 0.443114823940559 2066 521171 SGTC_2893 9048488 25.97 µM 0.142985502119886 0.437886865189451 no 1443 0.443150815584458 2008 6467338 SGTC_1053 3366-3204 134 µM 0.142537456717252 0.438085911261949 no 1444 0.443327747608004 2012 3632071 YPR165W RHO1 SGTC_1706 st031321 9.9705 µM 0.14238181078217 0.438155061298201 no 1445 0.443389214449882 2138 6103185 SGTC_1102 cgs 12066b 26.1 µM 0.140033385783218 0.439198642443249 no 1446 0.444316806113139 2062 6438352 A 5-HT1B full agonist. SGTC_1140 3229-1848 2.98 µM 0.139726894678493 0.43933487074035 no 1447 0.444437887988058 2147 2849525 SGTC_1051 3253-3903 78 µM 0.139144609056372 0.439593703181084 no 1448 0.444667939069043 2149 5509239 SGTC_3334 9142812 21.919 µM 0.138425649930563 0.439913324131754 no 1449 0.444952013219439 2112 45283678 SGTC_2921 7974240 10.71 µM 0.137575167843948 0.440291465569078 no 1450 0.445288091036061 2110 2979074 YDR527W RBA50 SGTC_1627 st003713 25.6 µM 0.137172992910083 0.440470299619784 no 1451 0.445447028814337 2042 16195070 YER133W GLC7 SGTC_2393 9031399 185.94 µM 0.134278613615284 0.441757691491072 no 1452 0.446591131969427 2129 1526623 YDL150W RPC53 SGTC_131 0141-0277 33.849 µM 0.133344130975679 0.442173472413162 no 1453 0.446960613863822 2147 1547771 SGTC_58 0957-0393 9 µM 0.132317841652448 0.442630174428636 no 1454 0.447366447927398 2096 6997992 SGTC_931 2812-0076 566 µM 0.131285591436519 0.443089605972804 no 1455 0.447774694750828 2074 3450959 SGTC_522 1273-0010 11.6 µM 0.130050778995553 0.443639293918734 no 1456 0.448263125981423 2091 5705015 SGTC_84 0443-0269 128.823 µM 0.129934067833758 0.443691254576547 no 1457 0.448309295260926 2165 6150058 SGTC_662 k832-1615 104 µM 0.129220849633878 0.444008805506396 no 1458 0.448591449450015 2103 5878478 SGTC_688 0527-0193 473 µM 0.128754454066237 0.444216481392014 no 1459 0.448775972923392 2092 4007154 SGTC_2074 5212007 75.395 µM 0.128431361625181 0.444360356470842 no 1460 0.448903806837078 2192 758611 SGTC_1683 st010134 710 nM 0.128349974345273 0.444396599890954 no 1461 0.448936009153194 2057 3818134 SGTC_2873 9040596 71.43 µM 0.12771693960408 0.444678519056125 no 1462 0.449186492007264 2008 6463863 SGTC_3293 9120939 62.045 µM 0.124585488006695 0.446073505823628 no 1463 0.450425858884709 2124 934087 SGTC_1865 st057639 52.2 µM 0.124130140360931 0.446276408324141 no 1464 0.45060611707419 2199 688818 SGTC_2370 9071495 200 µM 0.123396002676346 0.446603569016611 no 1465 0.450896761143189 2016 21791103 SGTC_2810 7959871 45.46 µM 0.123234692374587 0.446675460124466 no 1466 0.450960627196838 2142 2974535 SGTC_2114 5491910 81.25 µM 0.122528103545551 0.446990385950441 no 1467 0.451240395130919 2156 2849228 SGTC_2123 5259487 200 µM 0.122229757100806 0.447123368665717 no 1468 0.45135853019011 2168 2173474 SGTC_2838 9002687 71.43 µM 0.122192788330042 0.447139847263682 no 1469 0.451373168867935 2023 6457060 SGTC_1067 clotrimazole 1.36 µM 0.121506713547321 0.447445677331541 no 1470 0.451644848731537 2087 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_781 4335-2806 94.4 µM 0.121177066457422 0.447592634525569 no 1471 0.451775394279561 2180 845254 SGTC_1843 st055809 45.5 µM 0.120981704724626 0.447679730491588 no 1472 0.451852763128918 2088 16413835 SGTC_288 1315-0019 35.1 µM 0.119386205184387 0.44839112850929 no 1473 0.452484694898188 2121 6811474 SGTC_2914 7968218 45.32 µM 0.119298482801858 0.448430246817766 no 1474 0.452519442732661 2155 2977111 SGTC_81 0411-0046 9.971 µM 0.119194454505501 0.448476637121783 no 1475 0.452560649996546 2144 12925265 SGTC_3339 9145883 14.936 µM 0.117873938867757 0.449065567940707 no 1476 0.453083771517766 2190 2030670 SGTC_283 0987-0079 11.7 µM 0.117700663638882 0.44914285453704 no 1477 0.453152420464536 2174 411556 SGTC_907 3448-6986 75.5 µM 0.116339555647249 0.449750021491048 no 1478 0.453691718783033 2183 590582 SGTC_1147 3809-1045 12.3 µM 0.116258692968065 0.449786096663352 no 1479 0.453723760897693 2051 325925 SGTC_2608 thymoquinone 42.66 µM 0.11625442847441 0.449787999188431 no 1480 0.45372545072633 2219 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_301 4119-0100 24.5 µM 0.115431300157103 0.450155244243104 no 1481 0.454051635417072 2102 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1705 st027868 56.3335 µM 0.114115653088354 0.450742318855675 no 1482 0.454573056956412 2201 292948 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.114072529156161 0.450761563663598 no 1483 0.454590149303937 2132 5379071 SGTC_1160 4092-0570 10.5 µM 0.114058751187772 0.450767712347033 no 1484 0.454595610275984 2049 4994975 SGTC_949 1165-0505 146 µM 0.114012893039501 0.450788177512951 no 1485 0.454613786462081 2092 6244267 SGTC_1121 fusaric acid 630.51 nM 0.113588212595479 0.450977706327423 no 1486 0.454782115928093 2042 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1233 0325-0408 14.2 µM 0.1130449171185 0.451220187626847 no 1487 0.454997472356311 2171 12874 SGTC_1143 3454-2408 5.08 µM 0.11262271145562 0.451408637216037 no 1488 0.455164839233589 2208 X1143 SGTC_1287 0971-0001 34.6 µM 0.112473953600247 0.451475037223574 no 1489 0.455223810348991 2130 4665869 SGTC_630 4356-0227 183 µM 0.112182058511507 0.451605332344779 no 1490 0.455339527299264 2200 779312 SGTC_1721 st082152 9.2685 µM 0.111317580549986 0.451991245561527 no 1491 0.455682257392433 2204 5296051 SGTC_2722 naftopidil 47.16 µM 0.110260288346377 0.452463294980587 no 1492 0.456101475245546 2183 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_419 nsc-638432 893 µM 0.110148248843235 0.452513321224891 no 1493 0.456145901938951 2101 368090 SGTC_2744 captopril 92.04 µM 0.109633067601998 0.452743362126655 no 1494 0.456350192283788 2216 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1495 4469-0029 237 µM 0.109352189359011 0.452868787751376 no 1495 0.456461576810808 2199 793680 SGTC_2013 4024628 200 µM 0.108025912298202 0.453461097473478 no 1496 0.456987568721237 2145 5230760 SGTC_1771 st048882 4.1505 µM 0.107383496436336 0.453748034983121 no 1497 0.457242373365857 2053 4580403 SGTC_1246 0422-0085 105 µM 0.107345886904655 0.45376483417435 no 1498 0.457257291169853 2213 264295 SGTC_1236 0330-0013 258 µM 0.107297473364128 0.453786459354699 no 1499 0.457276494467807 2115 4617066 SGTC_671 0560-0003 407 µM 0.106848090998346 0.453987194329789 no 1500 0.457454747360534 2177 3238678 SGTC_2799 7812892 81.82 µM 0.105488493407692 0.454594585454345 no 1501 0.457994099988474 2182 20205235 SGTC_577 r071-0003 38.6 µM 0.105212348672893 0.454717964286031 no 1502 0.458103656142258 2198 4568517 YMR134W ERG29 SGTC_1723 st034307 2.5525 µM 0.103510618008696 0.455478377268119 no 1503 0.45877886140514 2139 867466 SGTC_1548 st061468 90.8 µM 0.101840592551358 0.45622478150533 no 1504 0.459441602468608 2216 390799 SGTC_2875 9039966 71.43 µM 0.101809102883088 0.456238857047698 no 1505 0.459454100071004 2194 6463691 SGTC_565 1418-0001 44.5 µM 0.101687380593145 0.456293266115812 no 1506 0.459502409523815 2215 2862145 SGTC_721 1187-1332 279 µM 0.101246737736815 0.456490237438785 no 1507 0.459677297979478 2199 25730 SGTC_208 k072-0098 12.366 µM 0.100948528233806 0.456623545840096 no 1508 0.459795659937124 2254 5948901 SGTC_270 tamoxifen 5.46 µM 0.100783086808753 0.456697505119855 no 1509 0.459861326621852 2251 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2541 muurolladie-3-one 83.07 µM 0.100368701611215 0.456882759321428 no 1510 0.460025808380527 2192 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2741 miltefosine 3.04 µM 0.100220034512345 0.456949224417698 no 1511 0.460084820424387 2177 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2237 6667747 47.222 µM 0.0996071304885715 0.457223250162685 no 1512 0.460328116335798 2069 729940 YDL015C TSC13 SGTC_345 1362-0200 395 µM 0.0991583598080055 0.457423905771766 no 1513 0.460506267961421 2100 1419823 SGTC_2102 5377816 72.7585 µM 0.0986221006176824 0.457663693719094 no 1514 0.460719160904423 2218 1379702 SGTC_3295 9122362 53.5725 µM 0.0970032061165668 0.45838767447607 no 1515 0.461361924173155 2109 4730473 SGTC_3003 9075612 71.4286 µM 0.0966975529088572 0.458524380260417 no 1516 0.461483291610448 2165 6501993 SGTC_160 3453-0671 289.699 µM 0.0966384770684118 0.458550802957656 no 1517 0.461506749600495 2209 5322268 SGTC_1383 3049-0032 20.7 µM 0.0961091589129874 0.458787557868151 no 1518 0.461716938611418 2219 712864 SGTC_1470 k295-0292 231 µM 0.0959262691817686 0.458869364703111 no 1519 0.461789565496724 2223 5045612 SGTC_673 1082-0474 110 µM 0.095288431867984 0.459154683842495 no 1520 0.462042865437708 2198 3098046 SGTC_2968 9090663 33.37 µM 0.0944237019654378 0.459541530769281 no 1521 0.462386294235588 2100 25236811 SGTC_1999 st074831 12.5 µM 0.0941960997733287 0.459643357626638 no 1522 0.462476691465067 2097 17112523 SGTC_1501 4491-0275 38.4 µM 0.093782981794582 0.459828189079325 no 1523 0.462640775328226 2255 5104718 SGTC_2743 auranofin 4.32 µM 0.0935101249704546 0.459950271616467 no 1524 0.462749153188714 2202 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_312 4092-0653 6.84 µM 0.0926844870844222 0.460319704306676 no 1525 0.463077110734756 2210 1148278 SGTC_2667 digitoxin 100 µM 0.0924092959321816 0.460442846554477 no 1526 0.463186426973589 2256 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_710 3448-4187 58 µM 0.0906640379440084 0.461223900607323 no 1527 0.463879773233657 2222 3946412 SGTC_1916 st067606 49.2 µM 0.0902691264460284 0.461400655928707 no 1528 0.464036676745654 2207 19590279 SGTC_1009 4106-0057 9.87 µM 0.0897209181371017 0.461646036792046 no 1529 0.464254496355584 2257 2928005 SGTC_2307 7538926 6.34 µM 0.0892954266896862 0.461836499024858 no 1530 0.464423564262549 2148 96582 SGTC_528 3492-0019 172 µM 0.0892612125973519 0.461851814619263 no 1531 0.464437159421547 2249 2869262 SGTC_2251 lansoprazole 556 µM 0.0891898084905599 0.461883778131883 no 1532 0.464465532372398 2050 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2817 7995342 71.43 µM 0.0881568395116567 0.462346206382285 no 1533 0.46487601039201 2178 18879975 SGTC_2017 5132927 60.65 µM 0.0878827120754646 0.462468933325231 no 1534 0.464984948599431 2205 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2718 lomofungin 53.02 µM 0.0876891613163451 0.46255558821614 no 1535 0.465061867227058 2221 5351222 A RNA synthesis inhibitor. SGTC_2974 9094440 9.66 µM 0.0870379557106665 0.462847153446263 no 1536 0.465320671138549 2181 25236134 SGTC_403 arphamenine a 50 µM 0.086474388334629 0.463099496402997 no 1537 0.465544657470151 2190 5487158 An arginine aminopeptidase inhibitor. SGTC_1989 st071868 50.2 µM 0.0856181704068828 0.463482904969802 no 1538 0.465884976801816 2279 16414057 SGTC_1504 k297-0033 30 µM 0.0855202551369557 0.463526752930013 no 1539 0.46592389659461 2207 4388117 SGTC_744 1594-0068 283 µM 0.0839788618023632 0.464217070560673 no 1540 0.466536619114217 2206 668392 SGTC_186 3455-3465 67.277 µM 0.0830180667709719 0.46464742013698 no 1541 0.46691858699802 2261 755278 SGTC_851 0394-0702 453 µM 0.0821702508654784 0.46502719961362 no 1542 0.46725566489743 2267 762646 SGTC_878 0828-0289 13.7 µM 0.081714452806373 0.465231387728131 no 1543 0.467436892559479 2172 745350 YLR208W SEC13 SGTC_196 k015-0023 18.111 µM 0.0817008706903053 0.465237472376278 no 1544 0.467442292982719 2141 5211998 SGTC_2249 haloperidol 116.36 µM 0.0796911608604187 0.466137890498703 no 1545 0.46824144485329 2196 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_791 1348-1292 225 µM 0.0791318628441116 0.466388506000381 no 1546 0.468463870042058 2236 5437054 SGTC_433 pimozide 108 µM 0.0781822256548748 0.466814058814148 no 1547 0.468841550303977 2253 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2628 lathosterol 100 µM 0.0778105783504602 0.466980612306759 no 1548 0.468989365828421 2213 6710616 SGTC_422 cantharidin 155 µM 0.0774264018441411 0.467152786829948 no 1549 0.469142169093456 2267 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3354 9151612 71.43 µM 0.0755821348942738 0.467979408018315 no 1550 0.469875775045764 2251 27261949 SGTC_1802 st050112 57.9 µM 0.074608900282973 0.468415678605006 no 1551 0.470262946230821 2274 4662563 SGTC_1168 k815-0004 80.5 µM 0.0742336937112672 0.468583882116256 no 1552 0.470412218049206 2246 642433 SGTC_2511 berberine 10.47 µM 0.0741601482347552 0.468616852899071 no 1553 0.470441477798226 2245 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1351 1496-0003 46.5 µM 0.0731885233208384 0.469052457034805 no 1554 0.470828049479258 2262 3891978 SGTC_3216 9129716 49.47 µM 0.0729730076715703 0.469149083214663 no 1555 0.470913798493567 2228 8056934 SGTC_1375 2910-0797 186 µM 0.0729012276223812 0.469181266116295 no 1556 0.4709423585218 2212 742508 SGTC_651 3253-0966 34.4 µM 0.0719265482671289 0.469618287747844 no 1557 0.471330181150407 2233 781462 SGTC_1442 4112-3290 3 µM 0.0707545509225381 0.470143830208719 no 1558 0.47179655211429 2279 704353 SGTC_2840 9008771 71.43 µM 0.0695956126005576 0.470663567942282 no 1559 0.472257764556252 2276 2992978 SGTC_1467 k284-1082 293 µM 0.0690725753723874 0.470898145751903 no 1560 0.472465925279795 2300 3334705 SGTC_3202 9113761 49.47 µM 0.0682746405552973 0.471256032250649 no 1561 0.472783505459021 2258 4798415 SGTC_2706 st078239 82.5 µM 0.0677749423376535 0.471480166714389 no 1562 0.472982395501529 2298 15434492 SGTC_748 act1.228 77.9 µM 0.0677148321129415 0.471507129143627 no 1563 0.473006321047021 2239 4421505 YNR035C ARC35 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.066808848226832 0.471913523781225 no 1564 0.473366939641675 2215 676296 Flavone; oxidizing agent. SGTC_3087 9117406 49.47 µM 0.0664088037596932 0.472092979932481 no 1565 0.47352618064536 2169 42546093 SGTC_125 0133-0007 11.75 µM 0.0650101938546458 0.472720427353354 no 1566 0.474082941951814 2289 26541 SGTC_508 roscovitine 141 µM 0.0648850324397687 0.472776580862997 no 1567 0.474132768931256 2301 160355 A CDKinase inhibitor. SGTC_665 3914-0008 307 µM 0.0640520614400614 0.473150305971569 no 1568 0.474464386422044 2257 1069549 SGTC_2037 5169046 200 µM 0.0635008083562549 0.473397647069231 no 1569 0.474683857784825 2238 5718022 SGTC_2701 st077767 14.721 µM 0.0630595917394912 0.473595623428373 no 1570 0.474859525673488 2251 5721188 SGTC_929 2805-0021 398 µM 0.0622922921069841 0.47393993056134 no 1571 0.475165033282715 2182 3098024 SGTC_2324 6149169 200 µM 0.0622280047748853 0.473968778832571 no 1572 0.475190630557777 2270 2888231 SGTC_2414 st077232 92.9 µM 0.0612268412948604 0.474418058046414 no 1573 0.475589276783199 2085 729801 SGTC_3152 9099253 49.47 µM 0.0605483087603878 0.474722572867787 no 1574 0.475859470785493 2246 25236131 SGTC_1417 3966-0327 90.4 µM 0.0601017040850078 0.474923010152224 no 1575 0.476037316377554 2247 651118 SGTC_641 4092-0595 30 µM 0.059954602291945 0.474989031193344 no 1576 0.47609589586509 2259 786260 SGTC_76 0433-0009 400.328 µM 0.0590961202332744 0.475374341832831 no 1577 0.476437774424151 2136 2841569 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0569425393655118 0.476341029421694 no 1578 0.477295483876451 2311 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_540 1187-0821 17.3 µM 0.0559314424576435 0.476794933451855 no 1579 0.477698211284103 2246 847520 SGTC_1910 st062352 60.4 µM 0.0540753756288443 0.477628241330304 no 1580 0.478437555468369 2303 2245730 SGTC_304 1310-0298 97 µM 0.0525388123972854 0.478318177650297 no 1581 0.479049685101712 2295 1550234 SGTC_2170 morpholine 200 µM 0.0521396513792511 0.478497416710791 no 1582 0.47920870934308 2271 121171 Reacts with secondary amines. SGTC_963 1269-2853 151 µM 0.0513594925745322 0.478847751347105 no 1583 0.479519531195781 2272 3668223 SGTC_3129 9127257 49.47 µM 0.0512405678143101 0.478901156612219 no 1584 0.479566912922673 2182 837894 SGTC_1409 3909-8004 61.9 µM 0.0508224235959259 0.479088934663673 no 1585 0.479733511259363 2251 2119279 SGTC_2703 st077852 53.4 µM 0.0506494038265904 0.479166634850332 no 1586 0.479802447378121 2254 6281836 SGTC_3239 9133757 49.47 µM 0.0502521981710711 0.479345016032327 no 1587 0.479960707969846 2305 17036923 SGTC_1 0258-0098 57.368 µM 0.0470433517141375 0.480786226270435 no 1588 0.481239338042583 2227 6790032 YDR047W HEM12 SGTC_257 daunorubicin 18.5 µM 0.0464005924777976 0.481074943738007 no 1589 0.481495482147095 2313 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_585 0kpi-0023 191 µM 0.0458600953337347 0.481317734351756 no 1590 0.481710880001463 2325 64601 SGTC_20 0481-0013 4.944 µM 0.0454921974218473 0.481482997584245 no 1591 0.481857497008471 2309 182045 SGTC_869 0564-0080 44.1 µM 0.0444133598232847 0.481967639912078 no 1592 0.482287456279262 2184 6843321 SGTC_2798 7813637 45.45 µM 0.0443168334814461 0.482011003402336 no 1593 0.482325926839476 2294 956368 SGTC_3080 9117754 49.47 µM 0.043692333862668 0.4822915587082 no 1594 0.482574825037106 2341 9550191 SGTC_2569 tetrandrine 100 µM 0.0434429133053818 0.482403612893579 no 1595 0.482674235051013 2241 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_172 1112-0046 2.638 µM 0.0431580949380776 0.482531571528395 no 1596 0.482787754668807 2293 2802135 YIL048W NEO1 SGTC_3333 9141820 12.094 µM 0.0423003340167379 0.482916943434919 no 1597 0.483129639509594 2243 1939433 SGTC_696 1560-0013 611 µM 0.0420954816249116 0.483008981194672 no 1598 0.483211291060455 2303 1650269 SGTC_1873 rapamycin 2 nM 0.0417299350028355 0.483173219220056 no 1599 0.48335699502916 2316 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2245 6637752 200 µM 0.0413066343850549 0.483363409354139 no 1600 0.483525722055846 2321 681890 SGTC_602 3130-1533 38.1 µM 0.040892282541094 0.483549582446164 no 1601 0.483690884971512 2320 720941 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0408710267556985 0.483559133014276 no 1602 0.483699357719757 2302 17037758 SGTC_3033 9090887 49.47 µM 0.0396568089936482 0.484104716180569 no 1603 0.484183367999251 2322 19325384 SGTC_2488 5268135 45.7 µM 0.0394709880871812 0.484188213540651 no 1604 0.484257441818673 2295 1270356 YLR208W SEC13 SGTC_1447 4239-0816 81.9 µM 0.0390363766622909 0.48438350592849 no 1605 0.484430693161512 2297 1341554 SGTC_282 k297-0036 65.7 µM 0.0375120473101782 0.485068491727085 no 1606 0.485038367271939 2315 5061378 SGTC_1353 1498-1206 8.11 µM 0.0371178798856925 0.485245625455637 no 1607 0.48519550788221 2327 6756808 SGTC_477 mead ethanolamide 10 µM 0.0370041680467347 0.485296726623964 no 1608 0.485240841198738 2340 16061185 SGTC_1244 0416-0015 52.5 µM 0.0357003560980802 0.485882666073829 no 1609 0.485760643304611 2315 96201 SGTC_198 3454-2873 16.191 µM 0.0351403682679394 0.486134336767274 no 1610 0.485983906026777 2314 710957 SGTC_1600 coumarin 106 71.1 µM 0.0348612999479772 0.486259758199567 no 1611 0.486095170005058 2302 100336 A hepatotoxic, DNA x-linker. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.034498482406399 0.486422821002002 no 1612 0.486239826246852 2289 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_453 enantio-paf c16 10 µM 0.0342685959889163 0.486526141117664 no 1613 0.486331483462406 2337 13871343 A lipid and platelet activating factor SGTC_1248 0469-0687 58.6 µM 0.0341348877855868 0.486586235328186 no 1614 0.486384794128471 2305 4017482 SGTC_2856 9022925 19.48 µM 0.0341156060396125 0.486594901398309 no 1615 0.486392481954515 2309 4944862 SGTC_567 1080-0542 68.4 µM 0.0339673382445576 0.486661539719483 no 1616 0.486451597984332 2352 5950415 SGTC_880 0833-0487 87.2 µM 0.033524866181205 0.486860409087365 no 1617 0.486628018314573 2347 76075 SGTC_1198 1612-1005 86.7 µM 0.0331749181319273 0.487017695791105 no 1618 0.486767549770572 2324 6998509 SGTC_1530 rhein 70.4 µM 0.0330306443753294 0.487082541272824 no 1619 0.486825075145361 2347 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1335 1486-0900 202 µM 0.0302950871713229 0.488312131276704 no 1620 0.487915857322711 2351 X1335 SGTC_1116 jasmonic acid  1.58368 µM 0.0299613934874777 0.488462129184185 no 1621 0.488048921435705 2337 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2919 7978188 46.38 µM 0.029605677745462 0.488622027974782 no 1622 0.488190768556916 2352 2980291 SGTC_1698 5-fluorocytosine 1.055 µM 0.0293699085094575 0.488728010281149 no 1623 0.488284785988985 2355 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2822 7994718 71.43 µM 0.0290418689643804 0.488875470993013 no 1624 0.488415599029964 2358 1018011 SGTC_2204 7233102 200 µM 0.028347119106381 0.489187780740625 no 1625 0.488692650035276 2345 2172480 SGTC_2059 5238311 157 µM 0.0280707089277224 0.489312036802489 no 1626 0.488802877876692 2340 703021 SGTC_777 1315-0167 517 µM 0.0276115327643933 0.489518454866424 no 1627 0.488985991678716 2220 4221767 SGTC_451 chloral hydrate 100 µM 0.0271351718909345 0.489732601111634 no 1628 0.489175960984698 2338 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1945 st075991 56.6 µM 0.0265847058791852 0.489980064726271 no 1629 0.489395485944819 2287 1084980 SGTC_3234 9132280 49.47 µM 0.0258595863300821 0.490306050223833 no 1630 0.489684667347173 2286 17612295 SGTC_162 k030-0015 37.8 µM 0.0258312835686797 0.49031877417536 no 1631 0.489695954744804 2359 1809920 YMR134W ERG29 SGTC_2381 9035592 200 µM 0.0247302351698529 0.490813775319796 no 1632 0.490135069136577 2256 4749657 SGTC_2183 6420625 130.508 µM 0.0245274976309886 0.490904922118596 no 1633 0.490215925185922 2354 2897619 SGTC_114 0364-0001 490.298 µM 0.0243935262627552 0.490965153264288 no 1634 0.490269356042357 2284 4003655 SGTC_2110 5483698 200 µM 0.0231498272757646 0.491524307873294 no 1635 0.490765379950876 2339 2848765 YHR062C RPP1 SGTC_2071 5230951 39.92 µM 0.0227699083552627 0.491695118986863 no 1636 0.490916905726388 2354 1799272 SGTC_2508 celastrol 40.54 µM 0.0212062854117588 0.492398137769491 no 1637 0.491540550188726 2372 122724 Celastrol is a natural product and antioxidant. SGTC_474 dl-dihydrosphingosine 5 µM 0.0205033917908714 0.492714172816879 no 1638 0.491820903194157 2360 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1278 0874-0585 172 µM 0.0204631937447889 0.492732246803499 no 1639 0.491836936530459 2353 766306 SGTC_2400 5203494 178.7 µM 0.0185271159778851 0.493602769861406 no 1640 0.492609172926798 2380 6777674 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0183906676286358 0.493664122641291 no 1641 0.492663598669312 2351 5377381 SGTC_2466 5983409 37.09 µM 0.0182661193160118 0.493720124807014 no 1642 0.492713277912063 2274 2879657 SGTC_1874 staurosporine 7.6 µM 0.0175275093904821 0.494052237436367 no 1643 0.493007893447524 2370 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_970 1315-0089 19.5 µM 0.0174221520385133 0.494099611236917 no 1644 0.493049918532672 2377 6811083 YLR033W RSC58 SGTC_2833 9001315 45.46 µM 0.016486582348899 0.494520292542328 no 1645 0.493423103184588 2334 2989378 SGTC_2242 6630449 61.2675 µM 0.0164400453183016 0.494541218200214 no 1646 0.493441666257852 2325 691249 YDR170C SEC7 SGTC_615 k087-0205 167 µM 0.0161878050625207 0.49465463982002 no 1647 0.493542282170376 2366 9642773 SGTC_1173 0443-0020 122 µM 0.0157864191337917 0.49483512673654 no 1648 0.493702391524727 2367 5331295 SGTC_2189 6047310 154.431 µM 0.0157392989973897 0.494856314814237 no 1649 0.493721187404164 2356 711535 SGTC_1414 3917-0015 5.4 µM 0.0153667424873028 0.495023839374465 no 1650 0.493869797971746 2372 6618702 SGTC_1765 st044815 90.4 µM 0.0151735009783821 0.495110733113776 no 1651 0.493946881192337 2341 645695 SGTC_3091 9116372 49.47 µM 0.0148517993254567 0.495255391260786 no 1652 0.494075207120968 2321 17169793 SGTC_2485 5633444 17.78 µM 0.0146806534867835 0.495332349901955 no 1653 0.49414347698881 2366 5724239 SGTC_991 3996-0057 64.7 µM 0.0145378570118427 0.495396560901955 no 1654 0.494200438461131 2370 715343 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0124806731454583 0.49632162299127 no 1655 0.495021061053973 2389 4000243 SGTC_514 4466-0038 2.65 nM 0.0116520771862793 0.496694226914697 no 1656 0.495351598942398 2330 5722064 SGTC_68 0986-0284 82.829 µM 0.011434379718457 0.496792121838134 no 1657 0.495438441880542 2315 423278 YIL048W NEO1 SGTC_322 k048-0136 19.3 µM 0.0103751380269664 0.49726844782311 no 1658 0.495860993032368 2355 6823282 SGTC_1967 st070177 51.4 µM 0.0103221734713948 0.497292265341403 no 1659 0.495882121701531 2386 5729214 SGTC_1328 1441-0025 69.2 µM 0.00981087695960976 0.49752218966552 no 1660 0.496086089160906 2387 4562601 SGTC_640 3381-0960 37.1 µM 0.0086466357345152 0.498045738875603 no 1661 0.496550534405144 2380 1745025 SGTC_2389 9091542 195.52 µM 0.00791913985020198 0.498372889249019 no 1662 0.496840753310232 2389 3626624 YOL127W RPL25 SGTC_1604 st002052 72.4 µM 0.00775419317130149 0.498447064904442 no 1663 0.496906555493786 2348 6254834 YHR062C RPP1 SGTC_326 k292-0812 17.5 µM 0.00774830993825012 0.498449710564461 no 1664 0.496908902493688 2398 3579357 SGTC_416 estradiol valerate 100 µM 0.00756183645551353 0.498533566777163 no 1665 0.496983292470354 2382 13791 A steroid. SGTC_335 4077-0256 27.6 µM 0.00756137746692956 0.498533773182164 no 1666 0.496983475575072 2393 3121989 SGTC_3055 9094636 49.47 µM 0.00732726754934225 0.498639051357994 no 1667 0.497076869331365 2389 25236176 SGTC_857 0438-0306 1.35 µM 0.00724641274301856 0.49867541142273 no 1668 0.497109124875808 2350 4686136 SGTC_316 k060-0003 58.6 µM 0.00563395517596333 0.499400528676343 no 1669 0.497752388964834 2395 6152314 SGTC_2234 tolnaftate 200 µM 0.00558136300631663 0.499424179261107 no 1670 0.497773369875038 2386 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2545 solidagenone 89.61 µM 0.00536337547630585 0.499522207801794 no 1671 0.497860333015043 2394 6708572 An anti ulcer agent SGTC_1899 st063254 59.6 µM 0.00518088348046764 0.499604274096724 no 1672 0.49793313577612 2397 3093813 SGTC_2618 avocadyne 43.43 µM 0.00498799444720479 0.499691015937257 no 1673 0.498010086372144 2394 3015189 SGTC_1418 3966-3099 2.4 µM 0.00491132616819628 0.499725493524426 no 1674 0.498040672215533 2394 740335 SGTC_38 0929-0051 58.268 µM 0.00467802378989145 0.49983040919585 no 1675 0.498133745328315 2394 1379719 SGTC_355 1311-2252 105 µM 0.00452952946337879 0.499897186841298 no 1676 0.498192985365714 2395 5338538 SGTC_1827 berberine 7.24 µM 0.00443857335848531 0.499938089648129 no 1677 0.498229271236807 2397 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1503 4585-0012 61.3 µM 0.00433132788356726 0.499986317757966 no 1678 0.498272055579787 2391 2922052 SGTC_2408 sulbentine 18.36 µM 0.00427047712484505 0.499986317757966 no 1679 0.498296331295708 2374 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1029 k015-0030 64.7 µM 0.00301713255428088 0.499422691009533 no 1680 0.498796340084693 2374 2208316 SGTC_211 3455-0679 143.504 µM 0.00238617050853977 0.499138948903526 no 1681 0.499048056599261 2366 748649 SGTC_330 1488-0319 80.1 µM 0.00211709233794942 0.499017945225106 no 1682 0.499155402985803 2401 6846614 SGTC_3255 9139072 49.47 µM 0.00182920590838427 0.498888483627117 no 1683 0.49927025283054 2393 17646060 SGTC_1266 0828-0227 32.9 µM 0.000879288110074175 0.498461309564296 no 1684 0.499649214841439 2402 3913820 SGTC_2175 5807670 165.306 µM 0 0.498065898938492 no 1685 0.5 2405 241186 SGTC_1734 st037168 69.4 µM -0.000149637775516215 0.497998607900618 no 1686 0.499940303164824 2406 708907 SGTC_1033 k072-0102 21.3 µM -0.000776407319095997 0.497716754758576 no 1687 0.499690258324719 2407 5965931 SGTC_1968 st069590 43.6 µM -0.00141566090326533 0.497429288820421 no 1688 0.499435233199617 2409 6384066 SGTC_3106 9121286 49.47 µM -0.00173128956653407 0.497287354252793 no 1689 0.49930931573733 2417 15943471 SGTC_1329 1447-1697 50.6 µM -0.00187099984999503 0.497224528259095 no 1690 0.499253579488704 2424 2840515 SGTC_942 3253-1115 227 µM -0.00275420314838567 0.496827364270977 no 1691 0.498901233304435 2412 46497897 SGTC_3288 9119690 36.221 µM -0.00325403219764056 0.496602599609627 no 1692 0.498701831265566 2416 17595618 YKL019W RAM2 SGTC_513 4245-1575 41.7 µM -0.00368473772045429 0.49640891949027 no 1693 0.498530005657545 2419 719745 SGTC_1040 k898-0338 155 µM -0.00423199124141918 0.496162831169606 no 1694 0.498311684803061 2416 20969351 SGTC_3341 9147222 25.867 µM -0.00689337516165682 0.494966085709654 no 1695 0.497249962973025 2428 1939759 SGTC_3249 9135183 49.47 µM -0.00726324677860415 0.494799768748149 no 1696 0.497102409243996 2435 4902779 SGTC_1935 st074532 41.6 µM -0.00750293223541744 0.494691991948814 no 1697 0.49700679118761 2453 2829742 SGTC_1367 1812-0510 76.9 µM -0.00799284017805823 0.494471701490662 no 1698 0.496811352063909 2423 1142582 YDR527W RBA50 SGTC_43 0570-0105 72.5 µM -0.00918128981354218 0.493937314119061 no 1699 0.496337246764123 2420 1114046 YDL195W SEC31 SGTC_2300 7976697 71.57 µM -0.00933944641380196 0.493866199670978 no 1700 0.496274154114715 2429 2236109 SGTC_2802 7925815 54.55 µM -0.00951099673710429 0.493789063012304 no 1701 0.496205718477418 2426 1262923 SGTC_3272 9137413 49.47 µM -0.0109866200605347 0.493125566998613 no 1702 0.4956170609137 2423 17614870 SGTC_1979 st071809 45.3 µM -0.0123616811864015 0.492507304630083 no 1703 0.495068528315541 2472 4976333 SGTC_2064 5220758 200 µM -0.0124577258468824 0.49246412116931 no 1704 0.495030214989937 2444 788518 SGTC_2676 harmalol 100 µM -0.0131111660962093 0.492170324683756 no 1705 0.494769551353972 2422 5459187 A monoamine oxidase inhibitor SGTC_2297 7971671 152.32 µM -0.013837385582617 0.491843810557608 no 1706 0.494479858001351 2445 909016 SGTC_1825 st052143 62.6 µM -0.0140587904055617 0.491744266244162 no 1707 0.4943915388482 2431 674173 SGTC_2429 5902844 64.44 µM -0.0147262832808389 0.491444162458643 no 1708 0.494125275302353 2445 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_475 α-linolenic acid 10 µM -0.0149471407768843 0.491344866320979 no 1709 0.494037175606555 2443 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2021 4019055 173 µM -0.0152984558237954 0.491186918398657 no 1710 0.493897037206996 2435 44827708 YER133W GLC7 SGTC_2567 aureobasidin a 60 nM -0.0160531872647641 0.490847602986373 no 1711 0.493595979923873 2469 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_980 1473-0395 201 µM -0.0165579456010146 0.490620675240136 no 1712 0.493394637251713 2436 768876 SGTC_1572 epiandrosterone 68.9 µM -0.0177549283268198 0.490082551588838 no 1713 0.492917180535249 2444 441302 A steroid. SGTC_3270 9137563 49.47 µM -0.0190982152506913 0.489478675975754 no 1714 0.492381377597481 2534 17015724 SGTC_456 gingerol 170 µM -0.0193576370567407 0.489362055449975 no 1715 0.492277902400718 2463 442793 A herb. SGTC_2054 5233173 129 µM -0.019923884081753 0.489107507832286 no 1716 0.492052046091613 2469 6889 SGTC_2047 4141938 200 µM -0.0205150101424788 0.488841780962696 no 1717 0.491816269117185 2459 3807862 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0208549045579991 0.488688991627626 no 1718 0.491680699870551 2449 688664 SGTC_1191 1487-1166 10.6 µM -0.022091694162007 0.488133044149975 no 1719 0.49118740597964 2494 3955771 SGTC_2033 5192550 145 µM -0.0233170147260343 0.487582274838779 no 1720 0.490698699807416 2452 182073 SGTC_3007 9078383 71.4286 µM -0.0237367314850112 0.487393621755222 no 1721 0.490531303382219 2466 6496995 SGTC_905 2-aminofluorene 215 µM -0.0239448281569267 0.48730008810408 no 1722 0.490448308411339 2450 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1985 st071382 65.5 µM -0.0241657446125066 0.487200793082227 no 1723 0.490360200992618 2450 6123237 SGTC_2572 astragaloside iv 100 µM -0.0247783395383991 0.486925455035288 no 1724 0.490115884149032 2540 45006101 An anti-inflammatory agent. SGTC_1591 genipin 88.4 µM -0.024914444912701 0.48686428170388 no 1725 0.490061602718397 2516 442424 A DNA cross-linking agent. SGTC_3252 9135871 49.47 µM -0.0266305799615237 0.486092982081005 no 1726 0.489377191310943 2494 17682838 SGTC_1655 st012546 55.1 µM -0.026750892928461 0.486038910546958 no 1727 0.489329210475288 2494 720985 YLR208W SEC13 SGTC_1997 st073024 93.8 µM -0.0278924947105006 0.485525860227762 no 1728 0.488873947234781 2449 686268 SGTC_2908 7930301 100 µM -0.0284014082947917 0.485297155678904 no 1729 0.488671000499415 2452 2223178 SGTC_452 diindolylmethane 8 µM -0.0284688869821711 0.485266831279534 no 1730 0.488644091279026 2487 3071 Inhibits expression of several cancer promoting factors. SGTC_1684 st024538 14.6195 µM -0.0294314660960445 0.484834265043538 no 1731 0.488260238676667 2459 6732859 SGTC_2298 7976326 193.81 µM -0.0305354911221428 0.484338157489197 no 1732 0.487819994373759 2482 2235818 SGTC_2823 7987624 58.44 µM -0.03071215509208 0.484258773538809 no 1733 0.487749548687201 2489 2239440 SGTC_443 clozapine 122 µM -0.0308437966789465 0.48419962080061 no 1734 0.487697056160927 2452 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2434 5670830 169.91 µM -0.0309828597770983 0.484137133607085 no 1735 0.487641604513542 2499 1549830 SGTC_1483 3453-0561 55.9 µM -0.0311446585862777 0.484064430744612 no 1736 0.487577087263414 2487 4546991 SGTC_72 0744-0168 198.391 µM -0.0315735588945812 0.483871710758239 no 1737 0.487406064909494 2509 677577 SGTC_1521 st012942 49.4 µM -0.0322692644958046 0.483559113806666 no 1738 0.487128659906649 2557 24207259 SGTC_2883 9059145 45.46 µM -0.0330899723191372 0.483190363412345 no 1739 0.486801419651242 2457 16476510 SGTC_2978 9011784 42.97 µM -0.0341624794080101 0.482708499374156 no 1740 0.486373793079913 2520 2994934 SGTC_2305 7443522 69.23 µM -0.0346207691753185 0.482502603167472 no 1741 0.486191070009561 2492 5415886 SGTC_214 4373-3496 70 µM -0.0351319836478419 0.482272934945103 no 1742 0.485987248942102 2492 3779166 SGTC_3266 9136860 49.47 µM -0.0354046505584061 0.482150439005133 no 1743 0.485878538214524 2467 4871271 YPR165W RHO1 SGTC_253 dyclonine 31.25 µM -0.0355597971467658 0.482080739963764 no 1744 0.485816682630813 2464 3180 An oral anasthetic. SGTC_3145 9085516 49.47 µM -0.036006968736316 0.481879852822858 no 1745 0.485638401155479 2525 25236195 SGTC_961 1252-1571 372 µM -0.0366466001111788 0.481592513154262 no 1746 0.485383393474605 2478 6813498 SGTC_3305 9127027 53.8275 µM -0.0369820316967861 0.481441832050011 no 1747 0.485249666284082 2509 41905295 SGTC_810 3825-7150 143 µM -0.0373932029291365 0.48125713113319 no 1748 0.485085746079535 2477 22330411 YGL099W LSG1 SGTC_373 0844-0104 25.9 µM -0.037474905881768 0.481220430088538 no 1749 0.485053174146964 2483 5375804 SGTC_1103 duloxetine 36.1 µM -0.0379936204191184 0.480987426747095 no 1750 0.484846384262725 2518 60835 A selective serotonin reuptake inhibitor. SGTC_2959 9079155 11 µM -0.0380835473215465 0.480947032800672 no 1751 0.484810534564668 2542 16189457 SGTC_3225 9130819 49.47 µM -0.0391258654830089 0.480478851983073 no 1752 0.484395019540488 2481 4547121 SGTC_1175 0741-0056 27.6 µM -0.0392376957870481 0.480428622456379 no 1753 0.484350439936707 2499 765927 SGTC_1436 4092-1007 8.32 µM -0.0399378937180975 0.480114129730631 no 1754 0.484071320186103 2484 2881121 SGTC_893 0958-0369 48.9 µM -0.0412292917228282 0.479534133094833 no 1755 0.483556551051119 2570 6819948 SGTC_1496 4469-0713 57.4 µM -0.0426127678272106 0.478912830167243 no 1756 0.48300510874088 2478 746691 SGTC_683 panaxydol 45 µM -0.042955644871169 0.478758855963802 no 1757 0.482868445729015 2542 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2636 apigenin dimethyl ether 100 µM -0.0430283105875328 0.478726224713997 no 1758 0.482839483080778 2549 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3320 9137005 35.139 µM -0.0434479294102824 0.47853779357849 no 1759 0.482672235802371 2510 4908713 SGTC_1930 st074634 34.3 µM -0.0441744993505534 0.478211536459025 no 1760 0.482382654387836 2487 684253 YOR116C RPO31 SGTC_2250 alverine citrate 130 µM -0.0445835791937632 0.478027850696384 no 1761 0.482219615774736 2471 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1072 oxiconazole 14.9 nM -0.0450106355572652 0.477836098064589 no 1762 0.482049415799243 2481 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_601 0986-0029 62.9 µM -0.045415893135502 0.477654138052136 no 1763 0.481887906584071 2501 24747981 SGTC_2942 9052777 62.25 µM -0.0456529158436148 0.477547717387167 no 1764 0.481793446181636 2503 6469503 SGTC_1156 4092-0367 4.88 µM -0.0457574977988842 0.477500761714616 no 1765 0.48175176757327 2506 1357585 SGTC_1107 amlodipine 47 µM -0.0463326962002418 0.477242512172543 no 1766 0.481522539742153 2514 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2131 toluylene red 5.2905 µM -0.04648322936647 0.477174928159564 no 1767 0.48146255033196 2500 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1482 3346-2049 8.48 µM -0.0467594642717978 0.477050910266201 no 1768 0.481352468248738 2571 3826804 SGTC_808 0711-0032 135 µM -0.0505013542750213 0.475371182417084 no 1769 0.47986143511407 2480 4252555 SGTC_1341 1486-1360 280 µM -0.0507698264388355 0.475250682205622 no 1770 0.479754467435657 2499 3976547 SGTC_1384 3089-0840 101 µM -0.0511093967807258 0.475098273752672 no 1771 0.479619174116206 2484 1069836 SGTC_1070 indatraline 8.81 µM -0.0515722655042528 0.474890531488024 no 1772 0.479434759421581 2514 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3264 9137442 49.47 µM -0.0523731832817625 0.474531084013203 no 1773 0.479115670712156 2518 17015726 SGTC_1355 1499-0035 1.68 µM -0.0532058444408918 0.474157412267754 no 1774 0.478783949511435 2504 1548538 SGTC_2412 st077135 33.4 µM -0.0537007783030601 0.473935312503114 no 1775 0.47858678135113 2759 13258915 SGTC_2888 9058547 12.99 µM -0.0539464234768063 0.473825083131653 no 1776 0.478488924952315 2514 16476514 SGTC_2966 9084041 48.03 µM -0.0552116808280182 0.473257350913501 no 1777 0.477984911588116 2491 17741380 SGTC_1649 st011737 51.3 µM -0.0563565851959732 0.472743668929479 no 1778 0.477528870975335 2534 1761035 SGTC_2194 5927483 104.545 µM -0.0565969608843522 0.472635825772315 no 1779 0.477433127764625 2496 760979 SGTC_1404 3909-7820 48.3 µM -0.0566421663559034 0.472615544823777 no 1780 0.477415122274637 2511 23741373 SGTC_1518 st038567 90.8 µM -0.0581749198044582 0.471927933829792 no 1781 0.476804648988419 2503 77966 SGTC_7 0192-1582 4.227 µM -0.0587245069551877 0.471681402923138 no 1782 0.476585769645793 2512 252616 SGTC_1207 2099-0101 141 µM -0.0587905897070334 0.471651760599595 no 1783 0.476559451911639 2533 5837381 SGTC_1700 st030840 7.9285 µM -0.0602722295662665 0.470987192282793 no 1784 0.475969409659787 2599 5499307 SGTC_1276 0871-0068 94.2 µM -0.0603091894262093 0.470970615492577 no 1785 0.475954691583183 2571 3414906 SGTC_1611 st001856 99.4 µM -0.0603328304038108 0.470960012353062 no 1786 0.475945277340703 2524 647478 SGTC_1056 3448-1962 115 µM -0.0605209874899674 0.470875623352612 no 1787 0.475870350443199 2570 715507 SGTC_2649 anisomycin 9.56 µM -0.0612801844796293 0.470535134617631 no 1788 0.475568035816804 2554 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1071 trifluoperazine 6.31 µM -0.0615896755242888 0.470396338581327 no 1789 0.475444799536054 2622 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_507 nimesulide 162 µM -0.0618308868985249 0.470288166110093 no 1790 0.475348753174708 2550 4495 A COX2 inhibitor. SGTC_1912 st060209 90.8 µM -0.0627802980781414 0.469862419197434 no 1791 0.474970727385973 2568 688787 SGTC_476 mead acid 10 µM -0.063466870719278 0.469554559088388 no 1792 0.474697369687838 2519 5312531 An omega 9 fatty acid. SGTC_2428 5615643 7.78 µM -0.0635881709644136 0.469500169779534 no 1793 0.474649075441502 2567 2253075 SGTC_2363 9053361 176 µM -0.0641908833703342 0.469229930547256 no 1794 0.474409118220876 2567 6469797 YMR079W SEC14 SGTC_2362 9071156 126 µM -0.0645709969305214 0.469059505635742 no 1795 0.474257788799554 2573 653133 SGTC_94 0334-0113 514.748 µM -0.0646477544421434 0.469025091891072 no 1796 0.474227230829602 2521 6795178 SGTC_2010 4012422 159 µM -0.0655051564221324 0.468640696927528 no 1797 0.473885900462342 2576 952393 SGTC_19 0279-0214 38.434 µM -0.0658906723919637 0.468467869886512 no 1798 0.473732433399287 2533 3566274 YBR002C RER2 SGTC_2215 7188065 200 µM -0.0673739520975498 0.467802970404506 no 1799 0.473142002637448 2551 940217 SGTC_2491 paeonol 100 µM -0.0678585844208349 0.467585747018432 no 1800 0.472949103782423 2526 11092 Increases levels of cortical cytochrome oxidase. SGTC_1808 st050063 61.5 µM -0.0685064276743962 0.467295383815403 no 1801 0.472691251777305 2515 4011993 SGTC_201 4262-0159 12.803 µM -0.0695090153622591 0.466846058594763 no 1802 0.472292228395239 2567 1341029 SGTC_3208 9114115 49.47 µM -0.0697371547701314 0.466743820261078 no 1803 0.472201434263255 2599 650895 SGTC_539 4859-0462 2.54 µM -0.0703978298041835 0.466447757928765 no 1804 0.471938509265159 2567 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2772 vinpocetine 57.06 µM -0.072152109554925 0.465661718928293 no 1805 0.471240428411814 2593 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1813 st051246 8.6015 µM -0.0729772423044565 0.465292048358207 no 1806 0.470912113611754 2549 5291959 SGTC_385 1494-0393 12.4 µM -0.073502205756232 0.465056873239787 no 1807 0.470703244442549 2576 3090647 SGTC_1892 st058411 7.36 µM -0.0741621725781771 0.464761236125748 no 1808 0.470440672419834 2536 3934738 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0745068660544948 0.464606835806493 no 1809 0.47030353901648 2586 4213774 SGTC_3153 9100258 49.47 µM -0.0760658835562049 0.46390856398988 no 1810 0.469683341227148 2581 25236848 SGTC_3146 9095609 49.47 µM -0.0766909810065694 0.463628618802347 no 1811 0.469434689762308 2601 17173999 SGTC_3166 9102297 49.47 µM -0.0769400089453564 0.463517098523005 no 1812 0.469335634663569 2584 25237072 SGTC_1921 5740136 50 µM -0.0771588441436152 0.463419101594185 no 1813 0.469248590807455 2514 1774243 SGTC_2697 mebhydrolin 72.4 µM -0.0774797102006203 0.463275418083573 no 1814 0.46912096583057 2584 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1640 st009078 66.4 µM -0.0775554143599788 0.46324151853188 no 1815 0.46909085484469 2571 690618 SGTC_2626 ethyl orsellinate 100 µM -0.0778136773533433 0.463125873003284 no 1816 0.468988133242285 2560 75653 A natural product. SGTC_1614 st002383 48.6 µM -0.0778718150230727 0.46309984042861 no 1817 0.468965009832058 2542 1947235 SGTC_2754 granisetron 64.02 µM -0.0782671571705272 0.462922820433786 no 1818 0.468807771039107 2594 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_941 3237-0776 460 µM -0.0783680448137929 0.46287764775014 no 1819 0.46876764593814 2622 760008 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0786145224561554 0.462767288810666 no 1820 0.468669618020449 2583 5024745 SGTC_2087 5276107 200 µM -0.0790248902125317 0.462583555381778 no 1821 0.468506412721476 2539 144405 SGTC_108 0509-0257 621.132 µM -0.0792130184877993 0.462499327616845 no 1822 0.468431594937809 2558 536624 SGTC_1751 st044839 27.194 µM -0.0795472091456787 0.462349709747781 no 1823 0.4682986915412 2533 5291326 SGTC_122 0236-0016 402.397 µM -0.0803139316584798 0.462006466611339 no 1824 0.46799378907339 2557 6808838 SGTC_2858 9025781 8.96 µM -0.0803628844528509 0.461984552586753 no 1825 0.467974322656105 2610 4894980 YPL153C RAD53 SGTC_190 3970-0790 3.722 µM -0.080403719401932 0.461966272654667 no 1826 0.467958084414733 2525 2832352 SGTC_1330 1469-0054 61.8 µM -0.0805142814064155 0.461916779524202 no 1827 0.467914119095185 2602 7102664 SGTC_699 0375-0592 111 µM -0.0814335461857571 0.461505293144239 no 1828 0.467548585846722 2539 762578 SGTC_1779 st039427 55 µM -0.0817839452957417 0.461348456381292 no 1829 0.467409261549806 2533 1124498 SGTC_454 lyso-paf C-16 6.67 µM -0.0822140969348443 0.461155931035412 no 1830 0.4672382318311 2604 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_128 0906-2981 13.371 µM -0.0828070641833801 0.460890548341261 no 1831 0.467002476007974 2592 6740226 SGTC_1778 st046819 58.9 µM -0.0835756315002926 0.460546601711138 no 1832 0.466696921190885 2559 671715 SGTC_3214 9129694 49.47 µM -0.0837791352217427 0.460455535350044 no 1833 0.466616018684507 2582 17158655 SGTC_1606 st000094 49.2 µM -0.0840729986334139 0.460324037378868 no 1834 0.466499196294872 2541 1242210 SGTC_2765 myclobutanil 7.74 µM -0.0847012812134781 0.460042908124426 no 1835 0.466249438684434 2638 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1736 st036774 51 µM -0.0848797743982743 0.459963043788999 no 1836 0.466178485721135 2643 1272247 SGTC_1302 1159-0335 255 µM -0.0850119814633665 0.459903890586222 no 1837 0.46612593268176 2564 649284 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.085053401553912 0.459885358241653 no 1838 0.466109468088217 2727 94937 An inhibitor of serotonin biosynthesis. SGTC_2167 5876490 200 µM -0.0858378856578514 0.459534377690245 no 1839 0.465797644604111 2800 686534 SGTC_886 0866-0150 153 µM -0.0858701065067756 0.459519962657708 no 1840 0.465784837631759 2595 271463 SGTC_269 exalamide 29 µM -0.0863190452635788 0.459319121017939 no 1841 0.46560639952508 2589 3316 A derivative of salicylamide. SGTC_3021 9087658 49.47 µM -0.0865093444279039 0.459233990049861 no 1842 0.465530764071066 2564 25237042 SGTC_2150 5556613 200 µM -0.0866926081874895 0.459152008160502 no 1843 0.465457926054446 2593 743190 SGTC_1603 st002045 67.8 µM -0.0868744941765273 0.459070644325668 no 1844 0.465385636775682 2571 5887985 SGTC_971 1315-0384 26.7 µM -0.0885200140608106 0.4583346252313 no 1845 0.464731688929094 2602 6769120 SGTC_1523 st012844 44.7 µM -0.0910135444927263 0.457219575356196 no 1846 0.463740914388091 2689 4274103 SGTC_1285 0929-0069 65.5 µM -0.0911061468204773 0.457178172139694 no 1847 0.463704124250915 2600 1206237 SGTC_1249 0481-0015 10.2 µM -0.0924233467933145 0.456589292389427 no 1848 0.463180845377556 2577 4227577 SGTC_1743 st037606 46.3785 µM -0.0924560122484116 0.456574689871275 no 1849 0.463167869305893 2607 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2595 hexamethylquercetagetin 100 µM -0.0932328774900038 0.456227423231118 no 1850 0.462859277836237 2652 386331 SGTC_2970 9090938 41.86 µM -0.0932723753265615 0.456209768188559 no 1851 0.462843588843917 2606 17217104 SGTC_3307 9126885 69.2785 µM -0.0935846588064975 0.456070184396923 no 1852 0.462719548311851 2576 24824909 SGTC_121 0557-0495 61.343 µM -0.0939711294007557 0.455897448118282 no 1853 0.462566045313983 2581 3104427 SGTC_1256 0570-0116 285 µM -0.094760581385431 0.45554462186192 no 1854 0.46225249871247 2610 410638 SGTC_684 1140-0066 328 µM -0.0950050680093249 0.455435361641933 no 1855 0.462155400721134 2615 6813534 SGTC_1878 temozolomide 1 mM -0.095159575298345 0.455366314610667 no 1856 0.462094039232636 2555 5394 DNA alkylating agent. SGTC_1208 2323-2347 50.3 µM -0.0956172634754218 0.455161788427068 no 1857 0.461912276876375 2600 5412760 SGTC_2007 4011539 71.82 µM -0.0990927537511244 0.453609094778621 no 1858 0.460532312720236 2584 45595301 SGTC_2028 5153890 36.43 µM -0.100188270564597 0.453119812662714 no 1859 0.460097428946692 2586 2830968 YPR165W RHO1 SGTC_1564 D-Arginine 115 µM -0.100295240797351 0.453072041184912 no 1860 0.46005496786809 2617 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2075 5212009 200 µM -0.100481041377756 0.452989066741007 no 1861 0.459981216722676 2634 780898 SGTC_489 paxilline 115 µM -0.10082545572066 0.452835264318342 no 1862 0.459844509532382 2640 105008 A toxic potassium channel blocker. SGTC_568 1193-0097 7.48 µM -0.101592435175242 0.45249278575132 no 1863 0.459540092118526 2597 3646150 SGTC_1991 st073000 8.92 µM -0.102287186148317 0.452182589794868 no 1864 0.45926436296568 2775 4301969 YIL048W NEO1 SGTC_2291 7917025 104.35 µM -0.10249850127127 0.452088246521475 no 1865 0.45918050119881 2602 2964612 SGTC_1274 0865-0114 173 µM -0.10311904292164 0.451811216551971 no 1866 0.4589342457627 2644 870624 SGTC_597 k018-0003 82.8 µM -0.103692012486741 0.451555445139103 no 1867 0.458706882798445 2690 6786234 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.103706955718665 0.451548774806378 no 1868 0.458700953279078 2603 65057 A dermal irritant. YDR527W RBA50 SGTC_966 1300-0360 30.2 µM -0.103800840826152 0.451506866855654 no 1869 0.458663699596368 2606 70588 SGTC_2108 5365811 200 µM -0.104151395172475 0.451350392992083 no 1870 0.458524602573855 2665 780283 SGTC_1663 st014140 55.4 µM -0.104467688429345 0.451209218436015 no 1871 0.45839910442181 2597 4207120 SGTC_1859 st055998 20 µM -0.104470460592896 0.451207981133829 no 1872 0.458398004507085 2592 676301 SGTC_2496 diffractaic acid 79.83 µM -0.105038848963097 0.450954301884798 no 1873 0.458172491098205 2659 94870 An apoptosis inducer which activates caspases. SGTC_2688 kanamycin b 96.69 µM -0.105668440421011 0.450673330275405 no 1874 0.457922710510139 2652 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1138 3761-0006 1.03 µM -0.106491627717289 0.450305998781301 no 1875 0.45759614887561 2576 12061087 SGTC_3143 9086658 49.47 µM -0.108196940354098 0.449545171605129 no 1876 0.456919735976576 2682 25236626 SGTC_3161 9100388 49.47 µM -0.108345280452063 0.449478998228619 no 1877 0.456860902692767 2609 25236368 SGTC_2877 9040724 71.43 µM -0.108446120615416 0.449434015009596 no 1878 0.456820908935458 2609 6463895 SGTC_2310 7668677 200 µM -0.109493790355591 0.448966704485004 no 1879 0.456405423368221 2719 2197143 SGTC_3095 9117207 49.47 µM -0.109906403401634 0.448782678838332 no 1880 0.456241802066239 2609 17015229 SGTC_2472 5377652 49.4 µM -0.110119928910202 0.4486874506674 no 1881 0.456157131645217 2642 1610903 SGTC_1373 2887-0003 58.5 µM -0.110401381187572 0.448561933012887 no 1882 0.456045528898595 2697 776948 SGTC_1635 st007035 42.4 µM -0.110526237393642 0.448506253256154 no 1883 0.455996021453547 2580 3716403 SGTC_2983 9022671 12.99 µM -0.110931425447025 0.44832556620912 no 1884 0.455835362741888 2820 6405161 SGTC_1036 k216-0215 33.5 µM -0.111422510487294 0.448106589164931 no 1885 0.455640655207574 2594 622330 SGTC_2162 5663267 200 µM -0.111474139523825 0.448083568461062 no 1886 0.455620185720543 2609 6456493 SGTC_3167 9103034 49.47 µM -0.113713388415246 0.447085286309348 no 1887 0.454732499473671 2600 5127859 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.113963022806448 0.446974017160683 no 1888 0.454633552972885 2597 6312947 SGTC_920 mycophenolic acid 780.421 nM -0.114462841052165 0.446751246505398 no 1889 0.454435450649222 2635 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_700 3453-2283 142 µM -0.115224821516599 0.446411661632767 no 1890 0.454133462490142 2741 565664 SGTC_2815 7968870 71.43 µM -0.115225207684898 0.44641148954261 no 1891 0.454133309450597 2625 2977326 YHR190W ERG9 SGTC_2368 9071271 200 µM -0.115653920438302 0.446220446315959 no 1892 0.453963413629022 2644 27209959 SGTC_2345 9052315 157.45 µM -0.116142203116016 0.446002872712905 no 1893 0.453769920931589 2705 6469265 SGTC_2965 9082772 38.63 µM -0.116211317769071 0.445972077265617 no 1894 0.453742533623139 2673 16459634 SGTC_2720 fluspirilene 36.88 µM -0.116213764758018 0.445970986965616 no 1895 0.453741563985594 2685 3396 An atypical antipsychotic. SGTC_1596 piperlongumine 63 µM -0.116678872429685 0.445763757292888 no 1896 0.453557266630018 2749 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1950 st077106 7.18 µM -0.118304368601005 0.445039630891302 no 1897 0.452913248033588 2694 13831864 SGTC_2259 7964009 200 µM -0.118820294660768 0.444809834252515 no 1898 0.452708864886803 2794 313134 SGTC_220 paclitaxel 373.376 µM -0.119000279217443 0.444729672384262 no 1899 0.452637567285235 2734 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1631 benzylvanillin 81.9 µM -0.119637791048552 0.444445754342789 no 1900 0.45238504089236 2733 75506 SGTC_2156 5649887 115 µM -0.120255791029162 0.444170553175942 no 1901 0.452140261770409 2735 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_742 0kpi-0133 140 µM -0.120763470369767 0.443944498952694 no 1902 0.451939192354813 2745 2728852 SGTC_1690 st023502 41.2 µM -0.12207995030609 0.44335839547623 no 1903 0.451417850218174 2673 24207482 SGTC_1753 st043925 64 µM -0.122251486156059 0.443282035950974 no 1904 0.451349926076645 2646 670181 SGTC_1394 3474-0001 65.7 µM -0.122886783664874 0.442999250366933 no 1905 0.451098375703378 2685 5017666 YIL048W NEO1 SGTC_2326 6164455 177.58 µM -0.123397511093626 0.442771934845193 no 1906 0.450896163935878 2690 2888790 SGTC_1969 st069479 40.1 µM -0.123958092069772 0.442522452100518 no 1907 0.450674228378435 2733 3895485 SGTC_2819 7996655 46.38 µM -0.124126485765623 0.442447514080302 no 1908 0.450607563857828 2707 6456960 SGTC_2926 9010726 65.15 µM -0.124303844600952 0.442368588649221 no 1909 0.450537351680623 2717 2994293 SGTC_3235 9132602 49.47 µM -0.124790900646459 0.442151858426262 no 1910 0.45034454565543 2707 4912240 SGTC_2081 5214970 32.255 µM -0.125411789893987 0.44187560021123 no 1911 0.450098777410439 2650 2063512 SGTC_826 1683-5028 118 µM -0.12613212922148 0.441555128149678 no 1912 0.449813667561242 2703 722377 SGTC_1681 tripelennamine 100 µM -0.126821516879278 0.441248462013097 no 1913 0.449540832619036 2619 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_624 k048-0052 28 µM -0.1271071414023 0.441121415552215 no 1914 0.449427799644668 2694 6835531 SGTC_1007 4101-0031 70 µM -0.127212799112856 0.441074420288095 no 1915 0.449385987729081 2662 1146276 SGTC_2958 9077254 16.72 µM -0.127626353448178 0.440890484337299 no 1916 0.449222337320954 2787 16457351 SGTC_1182 1222-0449 220 µM -0.127678347746021 0.440867359811783 no 1917 0.449201762913207 2702 658318 SGTC_1392 3455-1037 33.9 µM -0.128927619267711 0.440311805625687 no 1918 0.448707461018798 2767 981132 SGTC_558 k064-0027 21.3 µM -0.128930464787984 0.440310540349357 no 1919 0.448706335216381 2731 5088526 SGTC_2663 amphotericin b 100 µM -0.129197215300267 0.44019193096694 no 1920 0.448600799806306 2640 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1104 tacrolimus 29.8 µM -0.129310736830962 0.440141455770345 no 1921 0.448555888000857 2629 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3260 9137109 49.47 µM -0.130817972850402 0.439471384360371 no 1922 0.447959652450728 2628 17478346 SGTC_724 3910-0327 137 µM -0.131150007389003 0.439323795114768 no 1923 0.447828321293011 2681 2885483 SGTC_2360 9040895 200 µM -0.131334241327193 0.439241906825346 no 1924 0.447755452856829 2685 4914414 SGTC_3124 9127567 49.47 µM -0.132205288638967 0.43885477903451 no 1925 0.447410959056366 2736 17592030 SGTC_1385 3091-4834 14.1 µM -0.132512943273736 0.438718059134421 no 1926 0.447289293026213 2744 4072814 SGTC_2411 st077133 39.94 µM -0.132513360253265 0.438717873836143 no 1927 0.447289128129594 2945 1403142 YNL221C POP1 SGTC_2186 6124449 200 µM -0.133334614242294 0.438352949301858 no 1928 0.446964376889859 2758 3834182 YLR033W RSC58 SGTC_16 erodoxin 22.806 µM -0.134048854295374 0.438035619051299 no 1929 0.446681971435244 2645 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1671 st016596 74.5 µM -0.135780533729807 0.43726641568226 no 1930 0.445997390180264 2685 2829167 SGTC_1662 st014054 52 µM -0.135909817850663 0.437208997794758 no 1931 0.445946286987298 2618 2838777 SGTC_2961 9083290 32.55 µM -0.136421647775951 0.436981695995745 no 1932 0.44574398060439 2635 17741490 SGTC_3056 9094900 49.47 µM -0.138821871492277 0.435916044127095 no 1933 0.444795455189288 2703 25236784 SGTC_1806 st050005 60.3 µM -0.13905284151622 0.435813522411816 no 1934 0.44470419655542 2655 5194765 SGTC_2314 7727897 200 µM -0.139843525460494 0.435462590629523 no 1935 0.444391811410154 2679 900724 SGTC_1213 1315-0166 115 µM -0.140204842432174 0.435302243063592 no 1936 0.444249072995579 2788 768401 SGTC_566 0958-0068 16.5 µM -0.142180168487405 0.434425808911177 no 1937 0.443468847947987 2781 6815365 SGTC_1444 4112-3581 28 µM -0.142981409865008 0.434070397024922 no 1938 0.443152431554571 2656 2877249 SGTC_2658 polymyxin b sulfate 77.05 µM -0.144419943657673 0.433432431077356 no 1939 0.442584434567409 2691 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3058 9093861 49.47 µM -0.145318906891225 0.433033843685336 no 1940 0.442229543817553 2811 17217477 SGTC_803 4488-1585 147 µM -0.145995291928571 0.432733989153688 no 1941 0.441962552550927 2783 747204 SGTC_1123 mangostin 811.285 nM -0.146662215829742 0.432438366846516 no 1942 0.441699321716476 2757 5281650 An antioxidant. SGTC_3025 9087895 49.47 µM -0.147050581240926 0.432266236463739 no 1943 0.441546048089211 2738 17173641 SGTC_2566 crystal violet carbinol 226 nM -0.147352903074939 0.432132251005285 no 1944 0.441426738773545 2848 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_207 4185-0010 4.486 µM -0.148755764512407 0.431510621803373 no 1945 0.440873178491242 2680 3761753 SGTC_578 3460-0051 92 µM -0.149294924290485 0.431271756947644 no 1946 0.440660460109473 2657 2876744 SGTC_2334 9017922 200 µM -0.149993724877059 0.430962203568434 no 1947 0.440384783037222 2824 3163164 SGTC_2440 5628896 157.78 µM -0.151043369380471 0.430497313751973 no 1948 0.439970752255494 2696 5522048 SGTC_3018 9082602 49.47 µM -0.151885754448596 0.430124289217676 no 1949 0.439638522117198 2672 17332089 SGTC_548 1436-0017 110 µM -0.15320651665862 0.429539555608056 no 1950 0.439117709397055 2765 9677137 SGTC_2346 9031566 143.75 µM -0.153375378075466 0.429464807660687 no 1951 0.439051130293477 2789 4771086 SGTC_1286 0929-0070 131 µM -0.154515516062327 0.428960182160031 no 1952 0.438601639042982 2790 1420408 SGTC_2949 9072542 2.23 µM -0.155427896383385 0.428556445869458 no 1953 0.438241996630217 2770 16457352 SGTC_302 1094-0063 18.9 µM -0.155814476648173 0.42838540323656 no 1954 0.438089629642889 2671 5440289 SGTC_2624 nerol 100 µM -0.156997280561561 0.427862154727147 no 1955 0.437623495661249 2652 637566 A natural product oil. SGTC_927 2425-1185 123 µM -0.157550711196635 0.427617371716552 no 1956 0.437405422562227 2656 730375 SGTC_1713 st033146 12.748 µM -0.157610201202692 0.427591060874625 no 1957 0.437381982327008 2780 674619 SGTC_1218 1348-1416 30.7 µM -0.158604982937123 0.427151143265489 no 1958 0.436990051339517 2676 6787668 SGTC_224 benfluorex 43.875 µM -0.159027844399775 0.426964170649305 no 1959 0.436823468162416 2700 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2129 girgensonine 121.053 µM -0.159370815920258 0.426812534254882 no 1960 0.436688365268982 2751 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1694 st024011 44.9 µM -0.159377537850321 0.42680956242737 no 1961 0.436685717448803 2714 2787533 SGTC_843 0310-0051 143 µM -0.159877313286017 0.426588618729329 no 1962 0.436488859997753 2706 2065037 SGTC_3133 9127736 49.47 µM -0.160197429419629 0.426447111982146 no 1963 0.436362777135213 2657 27243420 SGTC_2852 9023854 51.95 µM -0.160346226191314 0.426381339865492 no 1964 0.436304173345638 2839 19798528 SGTC_3262 9137218 49.47 µM -0.160402139725352 0.426356625130703 no 1965 0.436282152093577 2636 17650664 SGTC_2032 5185112 25.99 µM -0.16062481397496 0.42625820218824 no 1966 0.436194454968626 2776 5718189 SGTC_3232 9132874 49.47 µM -0.162578830209679 0.425394716548106 no 1967 0.435425028125245 2702 3784940 SGTC_2945 9067681 61.76 µM -0.16417246866187 0.424690747576126 no 1968 0.434797686920972 2640 16456930 SGTC_1883 5-benzylidenerhodanine 20 µM -0.164931907055682 0.424355359927843 no 1969 0.434498789052879 2789 1273210 SGTC_3204 9114183 49.47 µM -0.165537470419727 0.424087966708793 no 1970 0.43426047975384 2673 17027248 SGTC_1794 st048918 76.9 µM -0.166290742219201 0.423755399970721 no 1971 0.433964075626978 2664 672303 SGTC_26 0302-0163 425.158 µM -0.166354251527111 0.423727363322777 no 1972 0.433939087111047 2699 3100915 SGTC_885 0865-0106 16.8 µM -0.166689868008172 0.423579209390017 no 1973 0.433807039077531 2697 2793380 SGTC_166 k072-0058 166.424 µM -0.166765758154649 0.423545710077751 no 1974 0.433777181184195 2708 5846229 SGTC_341 1486-1430 230 µM -0.166828809997531 0.423517878250069 no 1975 0.433752374625281 2687 2054753 YPL210C SRP72 SGTC_654 1124-0271 80.9 µM -0.166863094226372 0.423502744946924 no 1976 0.433738886251287 2732 5403748 SGTC_1838 st055369 84.5 µM -0.168103570573736 0.422955265914206 no 1977 0.433250900207282 2689 676036 SGTC_1669 st015249 58.4 µM -0.168141928873527 0.422938339005202 no 1978 0.43323581220671 2760 722793 SGTC_431 k089-0097 107 µM -0.168195971184626 0.422914491232312 no 1979 0.433214555162186 2715 5499420 SGTC_550 4123-0385 25.7 µM -0.169623831702746 0.422284508010851 no 1980 0.432652989578283 2717 5731123 SGTC_3070 9117005 49.47 µM -0.169967544693819 0.422132888774598 no 1981 0.432517830403682 2694 8779016 SGTC_1749 st037932 54.2 µM -0.170631585618982 0.421839998657414 no 1982 0.432256730198937 2837 594497 SGTC_832 4083-0019 164 µM -0.172848980026065 0.420862281278674 no 1983 0.431385067966588 2830 1990758 SGTC_2372 9071633 200 µM -0.173366308161215 0.420634245370406 no 1984 0.43118175313102 2707 21321366 SGTC_2319 6033012 152.6 µM -0.173491746157754 0.420578956875938 no 1985 0.431132457560111 2734 847246 SGTC_669 0108-0021 26.2 µM -0.174174737976747 0.420277946505982 no 1986 0.43086406912085 2662 17201 SGTC_89 0302-0250 142.109 µM -0.174706814322674 0.420043480389751 no 1987 0.430655006537377 2680 4203518 YLR208W SEC13 SGTC_737 1950-0117 57.9 µM -0.1754108641821 0.419733275613371 no 1988 0.430378402276144 2761 5393513 SGTC_1209 2323-2347 50.3 µM -0.176849973974679 0.41909935834826 no 1989 0.429813117053433 2707 5412760 SGTC_2659 sanguinarine 24.21 µM -0.177725657468895 0.418713728860648 no 1990 0.429469217138966 2707 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1996 st072960 66.8 µM -0.178481053288933 0.418381133836625 no 1991 0.429172599790831 2712 1719405 SGTC_144 4161-2749 112.381 µM -0.179021371325706 0.418143271700516 no 1992 0.42896046043867 2716 797501 YMR168C CEP3 SGTC_761 k216-0224 480 µM -0.179472491322517 0.417944699802239 no 1993 0.428783357683852 2751 1340404 SGTC_663 1486-0733 13.9 µM -0.179511050812123 0.417927727835404 no 1994 0.428768220487459 2729 722445 YPR165W RHO1 SGTC_3010 9080089 71.4286 µM -0.179999096887847 0.417712927481007 no 1995 0.428576638599081 2830 17027233 SGTC_1468 k284-1086 134 µM -0.180322969489393 0.417570397212484 no 1996 0.428449512093579 2751 15996457 SGTC_2582 agaric acid 100 µM -0.180761950051827 0.417377227374355 no 1997 0.428277215253397 2820 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_861 0443-0273 110 µM -0.181125724431318 0.417217166513152 no 1998 0.428134446678172 2812 6149169 SGTC_504 lovastatin 124 µM -0.182111102414054 0.416783668817692 no 1999 0.427747767980349 2737 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1906 st060206 94.7 µM -0.182175097492567 0.416755518932397 no 2000 0.42772265764334 2865 5133468 SGTC_2811 7967822 32.47 µM -0.183044133364931 0.416373293410117 no 2001 0.427381695073629 2858 2232244 SGTC_1471 k673-0312 37 µM -0.183247942116623 0.416283664231604 no 2002 0.427301739408755 2734 24099884 SGTC_3221 9128209 49.47 µM -0.183870394611624 0.416009954643899 no 2003 0.427057565239464 2779 16460723 SGTC_2396 5342950 42.78 µM -0.184743225736273 0.415626215277106 no 2004 0.42671522022918 2809 1886677 SGTC_3222 9128301 49.47 µM -0.184787688517824 0.415606669408223 no 2005 0.426697782350091 2770 4911358 SGTC_3325 9138760 55.175 µM -0.185188636378814 0.415430421893742 no 2006 0.426540540896237 2771 43844959 SGTC_2099 5377090 177.372 µM -0.185891639126807 0.415121439043903 no 2007 0.42626486946878 2811 2243829 SGTC_3139 9095020 49.47 µM -0.188773622188192 0.413855304272258 no 2008 0.425135123280009 2688 25236292 SGTC_2272 7805186 180 µM -0.190434197732716 0.41312617310746 no 2009 0.4244844510233 2735 2956062 YPR165W RHO1 SGTC_1227 3909-8010 46.6 µM -0.190508795022216 0.413093425687475 no 2010 0.424455225981318 2754 15982272 SGTC_715 0868-0130 184 µM -0.191426137751924 0.41269077145215 no 2011 0.424095871864595 2878 2876258 SGTC_2540 epiandrosterone 100 µM -0.191490143145701 0.412662680639633 no 2012 0.424070801142512 2771 441302 A steroid. SGTC_1343 1487-0095 224 µM -0.192069660494182 0.412408361307431 no 2013 0.423843819921495 2757 4560101 YGL055W OLE1 SGTC_3048 9093155 49.47 µM -0.193674404336511 0.411704316823316 no 2014 0.423215417364095 2762 25236002 SGTC_1084 voriconazole 435 nM -0.193722348893287 0.411683286611498 no 2015 0.423196645724245 2777 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_618 k072-0232 33.2 µM -0.193874125458503 0.411616713608929 no 2016 0.423137222088154 2846 5872756 YGL099W LSG1 SGTC_2995 9067767 71.4286 µM -0.193927981441337 0.411593091637582 no 2017 0.423116136787279 2833 11673567 SGTC_1768 st044301 37.178 µM -0.195092072442883 0.411082583843644 no 2018 0.422660434306366 2795 3931349 SGTC_141 0443-0274 32.331 µM -0.197100067892603 0.410202339158552 no 2019 0.421874615149511 2868 1627241 SGTC_3159 9100096 49.47 µM -0.19854718288967 0.409568247692971 no 2020 0.421308486422178 2691 25236875 SGTC_405 ebelactone b 50 µM -0.199283642451471 0.409245639273722 no 2021 0.421020436990586 2760 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_244 nsc-207895 1.295 µM -0.200557887406823 0.408687597550614 no 2022 0.420522144948009 2727 42640 SGTC_488 nitrendipine 139 µM -0.202422626744436 0.407871289113516 no 2023 0.419793170469204 2733 4507 Dihydropyridine L-type calcium channel blocker. SGTC_900 1112-0045 141 µM -0.20279650872286 0.40770766650936 no 2024 0.419647043437344 2790 56211 YIL048W NEO1 SGTC_332 4112-0506 40.9 µM -0.203179102685555 0.407540247929301 no 2025 0.419497522906491 2772 2790355 SGTC_2774 tamoxifen 10.92 µM -0.203323837554371 0.407476918068015 no 2026 0.419440962485565 2749 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3187 9109394 49.47 µM -0.203909788740626 0.407220555322069 no 2027 0.419211997741424 2800 17098090 SGTC_1832 st054113 55 µM -0.204373996431055 0.407017485452738 no 2028 0.419030624582082 2792 1251267 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.204824684038162 0.406820353919893 no 2029 0.418854550391079 2803 2374 Ca(2+)-ATPase inhibitor. SGTC_143 4032-1194 15.74 µM -0.206755616066866 0.405976028766862 no 2030 0.418100360179003 2710 1806963 SGTC_1002 4049-0206 172 µM -0.20678538587814 0.405963014941294 no 2031 0.418088734931031 2767 4662749 SGTC_855 0428-0020 25 µM -0.207345326660897 0.405718257093524 no 2032 0.417870088827643 2784 6812414 SGTC_859 0439-0102 54.6 µM -0.20943457800362 0.40480534251058 no 2033 0.417054500947723 2786 610143 SGTC_645 0845-0943 5.41 µM -0.210636056066828 0.404280581570954 no 2034 0.416585637397103 2825 1885106 SGTC_2459 5811157 9.22 µM -0.211258741939273 0.404008683214581 no 2035 0.41634268774647 2758 2870684 YBR192W RIM2 SGTC_3212 9128307 49.47 µM -0.212021897051138 0.403675511637179 no 2036 0.416044975639988 2771 27243542 SGTC_2737 bleomycin 30.5 nM -0.213515636506138 0.403023590408372 no 2037 0.415462397070132 2796 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_364 0083-0097 67.7 µM -0.214627026471668 0.402538714878975 no 2038 0.415029060431513 2933 5207356 SGTC_2768 sulfasalazine 50.2 µM -0.21532089271612 0.402236071918779 no 2039 0.41475857080274 2859 5384001 An antioxidant and salicylic acid derivative. SGTC_854 0422-0053 192 µM -0.215706812298127 0.402067771099582 no 2040 0.414608145390507 2801 3596728 SGTC_1842 st055362 61.2 µM -0.215837257195211 0.402010887748243 no 2041 0.414557302841969 2807 676032 SGTC_1037 k284-1091 78.7 µM -0.21655339213188 0.40169863844613 no 2042 0.414278205715311 2771 3334711 SGTC_1733 st037357 54.9 µM -0.216941200293004 0.401529572429282 no 2043 0.414127084456525 2750 1272339 YGL099W LSG1 SGTC_2281 7943571 200 µM -0.21720734942466 0.401413554658322 no 2044 0.414023378698386 2951 1244024 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.219016833065402 0.400625008760363 no 2045 0.413318467597458 2904 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2417 cerulenin 830 nM -0.219093537488889 0.400591591041528 no 2046 0.413288592410783 2771 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_667 1498-1044 59 µM -0.219190098175012 0.400549523604474 no 2047 0.413250984230755 2828 6739982 SGTC_1907 st060210 83.7 µM -0.219212436568433 0.400539791868566 no 2048 0.413242284050493 2968 688793 SGTC_3098 9119039 49.47 µM -0.221865630408649 0.39938436697439 no 2049 0.412209243347435 2782 17161528 SGTC_1043 0916-0009 19.3 µM -0.222526819604128 0.399096566001036 no 2050 0.4119518987859 2980 3101130 SGTC_1561 5-methoxyflavone 52.9 µM -0.225266292436666 0.397904720292137 no 2051 0.410886060256533 2799 94525 SGTC_757 1066-0008 322 µM -0.225895595693563 0.397631067250751 no 2052 0.410641311711687 2961 6842497 SGTC_1789 tunicamycin 25 nM -0.226226681990832 0.397487114312545 no 2053 0.410512559630827 2923 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3097 9117246 49.47 µM -0.226673641854832 0.397292802878823 no 2054 0.41033876220148 2811 16423892 SGTC_1369 1866-0067 208 µM -0.227122952432703 0.397097495184081 no 2055 0.410164068458798 2926 3531355 SGTC_2469 5655019 90.81 µM -0.228384488223235 0.396549265031545 no 2056 0.409673673715942 2944 2788239 SGTC_2374 9071832 200 µM -0.229251450489131 0.396172624581476 no 2057 0.409336742750587 2780 17381698 SGTC_2989 9073649 71.4286 µM -0.230804359629133 0.395498225884757 no 2058 0.408733397089334 2785 21367202 SGTC_35 0133-0054 64.071 µM -0.231870676515808 0.395035325895106 no 2059 0.408319230316385 2847 99677 SGTC_3005 9076496 71.4286 µM -0.232709064274743 0.394671476435003 no 2060 0.407993665080153 2900 21368410 SGTC_621 3584-0052 32.1 µM -0.233836352488919 0.394182392749348 no 2061 0.407556013307057 2875 2273927 SGTC_2584 androsterone 48.74 µM -0.235345909160889 0.393527719968565 no 2062 0.406970132616145 2951 2754130 A steroid. SGTC_1456 k015-0012 13 µM -0.237944548656513 0.39240143354253 no 2063 0.405962051381672 2878 2989616 SGTC_773 4358-1457 44.6 µM -0.238332658235489 0.39223329853775 no 2064 0.405811546701161 3004 1186886 SGTC_825 1988-2224 89.6 µM -0.238796063099704 0.39203257081605 no 2065 0.405631861562417 2820 1180859 SGTC_675 1309-0189 238 µM -0.239964677490762 0.391526503340049 no 2066 0.405178819951705 2877 4246530 SGTC_2423 st077119 87.2 µM -0.239977571943387 0.391520920430381 no 2067 0.405173821812989 2780 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_772 k072-0172 35.3 µM -0.241071617183652 0.391047313275135 no 2068 0.404749805166641 2857 5861980 SGTC_1289 0976-0073 69.1 µM -0.242937151347241 0.390240105001124 no 2069 0.40402704245029 2943 3391136 SGTC_784 4579-0127 173 µM -0.243058692509041 0.390187531059087 no 2070 0.403979965172638 3039 1948547 SGTC_2641 levomentholum 100 µM -0.243978627176204 0.389789668576979 no 2071 0.403623686426819 2871 16666 SGTC_1597 7-benzyloxygramine 47.5 µM -0.245150247747647 0.389283121675701 no 2072 0.403170048798327 2829 260807 SGTC_3322 9139058 2.11 µM -0.245199974884601 0.389261626441017 no 2073 0.403150797916895 3016 4908926 YPR165W RHO1 SGTC_2004 4023728 41.89 µM -0.245868847688833 0.38897252998714 no 2074 0.402891879818426 2989 360084 YDR527W RBA50 SGTC_2845 9003024 42.97 µM -0.24778112770529 0.388146354590781 no 2075 0.402151878793343 3076 2990173 SGTC_3122 9126309 49.47 µM -0.247801222708894 0.388137675488919 no 2076 0.402144104423227 2871 17591206 SGTC_2922 7999257 32.47 µM -0.248393195398125 0.387882025509768 no 2077 0.401915098964321 2814 2988377 SGTC_2225 6654152 15.4 µM -0.248682940354508 0.387756913637218 no 2078 0.401803022993393 2897 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2884 9058502 51.95 µM -0.249312221529064 0.38748523017642 no 2079 0.4015596391672 2949 6471554 SGTC_2061 5245884 80.95 µM -0.252467144675443 0.386123968614267 no 2080 0.40034000323496 2837 573863 SGTC_792 4534-1957 155 µM -0.252470981964037 0.386122313780517 no 2081 0.400338520397915 2898 1717904 SGTC_1154 4088-0362 150 µM -0.253278169580337 0.385774259579809 no 2082 0.400026632196993 2831 6618304 SGTC_348 k064-0012 10.7 µM -0.25418538275437 0.385383184737138 no 2083 0.399676171354198 2812 5066323 SGTC_2648 atorvastatin 78.68 µM -0.2558743004556 0.384655449039947 no 2084 0.399023949719351 2961 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2518 prenyletin 46.28 µM -0.25634030767535 0.384454723156024 no 2085 0.398844037851169 2965 3873459 A coumarin with calcium channel inhibitory activity. SGTC_958 1222-0007 33 µM -0.256537236358572 0.384369908276046 no 2086 0.39876801585722 3034 7312461 SGTC_2735 sertaconazole 140 nM -0.25686165058765 0.384230198935522 no 2087 0.398642787948792 2848 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2596 sinensetin 100 µM -0.259053938444136 0.383286482860652 no 2088 0.397796811831696 2913 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1819 st053448 58.6 µM -0.259811978144691 0.38296032960005 no 2089 0.397504405472997 2882 2857616 SGTC_380 3970-0968 6 µM -0.260103933892158 0.38283473518424 no 2090 0.397391801766218 2878 2891601 SGTC_3109 9122853 49.47 µM -0.261258190292574 0.382338314379796 no 2091 0.396946703218389 2913 1234709 SGTC_2797 7859098 81.82 µM -0.261467192187962 0.382248447816315 no 2092 0.39686612329269 2884 972681 SGTC_2881 9058953 51.95 µM -0.262160989072296 0.381950174767239 no 2093 0.396598663998665 2825 17122249 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.262589677896911 0.381765910412309 no 2094 0.396433428394898 2910 688788 SGTC_3151 9099821 49.47 µM -0.264003266232247 0.381158494318491 no 2095 0.395888700964179 2999 17174189 SGTC_1307 1187-1599 12.2 µM -0.267180897621209 0.379794142902703 no 2096 0.394664941593995 2867 1538471 SGTC_762 1165-0429 115 µM -0.267438535879354 0.379683588342371 no 2097 0.394565766122284 3025 5967793 SGTC_2923 7992654 58.14 µM -0.267997302020769 0.379443851293069 no 2098 0.394350697737438 2919 2985126 SGTC_2656 pseudo-anisatin 100 µM -0.269245959243079 0.378908286029804 no 2099 0.393870207626679 2898 6708809 A neurotoxin. SGTC_2745 rifampicin 24.3 µM -0.26957854756459 0.378765673742016 no 2100 0.393742253036749 2940 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3066 9117245 49.47 µM -0.270760547900204 0.378258971317981 no 2101 0.393287602486485 2928 17176980 SGTC_287 k060-0039 29.6 µM -0.271435942813017 0.377969535491764 no 2102 0.393027880468962 3017 5861974 SGTC_2653 dihydrofissinolide 100 µM -0.271527204281866 0.377930431268033 no 2103 0.392992789668021 2930 6857746 SGTC_2985 9022375 71.43 µM -0.271843187924034 0.377795046497414 no 2104 0.39287129802399 3083 4939335 SGTC_556 4058-0063 51.5 µM -0.27226294825687 0.377615221301008 no 2105 0.392709921718913 2933 6615692 SGTC_2399 5884133 200 µM -0.272528282993513 0.377501565661829 no 2106 0.392607923641481 2906 722445 SGTC_829 1635-0120 117 µM -0.273190080218673 0.377218132297484 no 2107 0.392353552449491 3019 285054 SGTC_2719 novobiocin 32.65 µM -0.274054289990414 0.376848109623338 no 2108 0.392021450360498 3006 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3240 9133527 49.47 µM -0.274183069995174 0.376792980459819 no 2109 0.391971968977397 2918 17617455 SGTC_1422 4031-0024 15.5 µM -0.274849661902328 0.37650766070011 no 2110 0.391715871060966 2947 782427 SGTC_2040 5100729 123 µM -0.27501054999029 0.376438806251213 no 2111 0.391654066497657 2885 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1431 4049-0260 9.09 µM -0.275698401233287 0.376144474446655 no 2112 0.39138986184483 2858 3854841 SGTC_1014 4130-3005 69.3 µM -0.276674855490195 0.375726773029512 no 2113 0.391014890425273 2875 743608 SGTC_133 0724-0033 378.92 µM -0.276854490432725 0.375649945773688 no 2114 0.390945919239637 2822 280309 SGTC_3236 9132701 49.47 µM -0.276895856381653 0.375632254856417 no 2115 0.390930037188875 2959 24282524 SGTC_2481 5478948 45.16 µM -0.276919770998857 0.375622027444945 no 2116 0.390920855488912 3038 77792 SGTC_2402 5553605 200 µM -0.277398040769948 0.375417507229726 no 2117 0.390737242930571 3086 6758546 SGTC_2997 9067075 71.4286 µM -0.277677975673783 0.375297816244255 no 2118 0.390629784414012 3000 27209819 SGTC_307 1501-1223 22.3 µM -0.277957662160486 0.375178243462096 no 2119 0.390522429598751 2985 2830329 SGTC_338 4055-0136 114 µM -0.279427038723691 0.374550246480482 no 2120 0.389958561614357 2895 2900563 SGTC_1877 wortmannin 25 µM -0.280295575626001 0.374179198710707 no 2121 0.389625372467707 3038 312145 A covalent inhibitor of PI 3-kinase. SGTC_3170 9103054 49.47 µM -0.280300340699191 0.374177163344229 no 2122 0.389623544708223 2951 16432970 SGTC_3034 9090421 49.47 µM -0.282387545211753 0.373285967027955 no 2123 0.388823182017476 2891 17173761 SGTC_102 gallobenzophenone 83.616 µM -0.282548868825362 0.373217113080419 no 2124 0.388761340206308 3083 70837 SGTC_841 0251-0215 91.2 µM -0.283437071665087 0.372838095001936 no 2125 0.388420906958063 2952 3888614 SGTC_2825 7998094 58.44 µM -0.283645946709995 0.372748980723986 no 2126 0.388340861093829 2965 2987815 SGTC_814 3342-0569 96 µM -0.283755193611931 0.372702374427398 no 2127 0.388298996982198 2912 4346283 SGTC_1678 st019265 80.2 µM -0.284386706141257 0.372432998658939 no 2128 0.38805702278885 3138 5367020 SGTC_579 4491-1009 110 µM -0.284925561616256 0.372203195687166 no 2129 0.387850585991818 3016 1271041 SGTC_321 4534-3890 65.3 µM -0.286680725046082 0.371454995892309 no 2130 0.387178398784176 3022 699746 SGTC_2336 9001819 198.65 µM -0.287331477133079 0.371177713259945 no 2131 0.386929261533907 3151 2989602 SGTC_1522 st012842 45.6 µM -0.28758365406809 0.371070279731924 no 2132 0.38683272934635 2832 3491067 YOR116C RPO31 SGTC_1787 fluconazole 80 µM -0.287757801670239 0.370996094468434 no 2133 0.386766070519772 2985 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_372 0155-0182 15.9 µM -0.288437280243289 0.370706688766317 no 2134 0.386506017104754 2904 771486 SGTC_812 4251-0442 148 µM -0.288868432641612 0.370523088865751 no 2135 0.386341030738136 3048 5723007 SGTC_1807 st050092 58.9 µM -0.28888305079634 0.370516864456378 no 2136 0.386335437261119 2930 5008496 SGTC_1785 bathophenanthroline 24 µM -0.289044082755984 0.370448299301671 no 2137 0.386273821706622 2936 72812 An iron chelator. SGTC_3110 9122132 49.47 µM -0.289241632395936 0.370364191050978 no 2138 0.386198237333011 3070 918317 SGTC_1981 st071826 47 µM -0.289545978764961 0.370234625415955 no 2139 0.386081799966664 3007 11838600 SGTC_3148 9097893 49.47 µM -0.289865925274298 0.37009843439902 no 2140 0.385959405334154 2928 17174100 SGTC_1782 st039423 80.636 µM -0.290135693650396 0.369983615266237 no 2141 0.385856215024103 2969 2068169 SGTC_2937 9044753 11.33 µM -0.291237509670825 0.369514779453823 no 2142 0.385434838371506 2878 6465530 YGL099W LSG1 SGTC_1497 4476-2978 41.3 µM -0.292384842541861 0.369026781817312 no 2143 0.384996198025225 3005 1528379 SGTC_234 nsc-17383 10.7 µM -0.292686807387783 0.368898381487812 no 2144 0.384880777353945 3071 408974 SGTC_157 1348-1695 65.819 µM -0.292728834050967 0.368880512231371 no 2145 0.384864714220677 2918 5380510 SGTC_3189 9110682 49.47 µM -0.293622527896885 0.368500590985353 no 2146 0.384523179717291 3038 17122418 SGTC_2229 7354935 190 µM -0.293737329724364 0.368451796495132 no 2147 0.384479313481027 3012 318112 SGTC_156 3474-0145 5.642 µM -0.29484880653 0.367979492697634 no 2148 0.384054690326491 2870 2265471 SGTC_1044 1222-0021 1.78 µM -0.295792110275205 0.367578807756306 no 2149 0.383694424313934 3039 4306703 SGTC_496 calpeptin 138 µM -0.296774501608957 0.367161672853681 no 2150 0.383319336838246 2978 73364 A calpain inhibitor. SGTC_258 haloperidol 50.781 µM -0.29773774762552 0.366752819461683 no 2151 0.38295166541128 2972 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2654 protoveratrine a 100 µM -0.297936606878565 0.366668431709288 no 2152 0.382875773866663 2937 5702278 A heart drug and vasodilator. SGTC_344 k064-0035 6.43 µM -0.299008096331956 0.366213846311977 no 2153 0.382466934013256 2938 5088750 SGTC_1737 st035557 69.7 µM -0.299145962032564 0.366155369632362 no 2154 0.382414339176274 2865 5716916 SGTC_723 4182-0001 115 µM -0.301355654720054 0.365218538389648 no 2155 0.381571652900077 2939 744821 YLR208W SEC13 SGTC_2268 7933382 153.85 µM -0.302491744343457 0.364737189213439 no 2156 0.381138612967081 2868 935025 YOR257W CDC31 SGTC_1166 k206-0078 225 µM -0.303209706924372 0.364433105909474 no 2157 0.380865025981239 2927 5404595 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.304005711359327 0.36409606874954 no 2158 0.380561769967168 2918 16486 A toxic proline analog. SGTC_1448 4255-0083 152 µM -0.30426747634122 0.363985257483682 no 2159 0.380462060660845 3093 5399660 SGTC_3073 9114972 49.47 µM -0.304410321849542 0.363924792420141 no 2160 0.380407652504897 3062 41905075 SGTC_1288 0973-0013 65.5 µM -0.30464722624724 0.363824520646309 no 2161 0.380317423652068 3047 4315430 SGTC_3182 9108849 49.47 µM -0.305404376734363 0.363504112906683 no 2162 0.380029094388575 3046 17133045 SGTC_2141 5621638 7.665 µM -0.307373716090494 0.362671183736471 no 2163 0.379279465994062 3065 2856238 SGTC_2991 9074669 71.4286 µM -0.307730378244953 0.362520403351418 no 2164 0.379143751099904 3138 17333109 SGTC_229 benomyl 22.8748 µM -0.307730911106865 0.36252017809781 no 2165 0.379143548349699 3019 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1151 3909-8316 15.3 µM -0.30802576812251 0.362395542212007 no 2166 0.379031362432099 3054 800431 SGTC_3331 9141060 1.957 µM -0.3086691854677 0.362123620730544 no 2167 0.378786593179396 2954 4906567 YPR165W RHO1 SGTC_2910 7948405 25.97 µM -0.310216561082849 0.361469952853728 no 2168 0.378198138711429 3116 2971328 SGTC_1790 st045711 43.5 µM -0.310223912369377 0.36146684836535 no 2169 0.378195343749445 3118 585119 SGTC_2214 7179297 48.276 µM -0.310292068355942 0.361438066154959 no 2170 0.378169431120484 2960 769744 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.310523763677478 0.361340227298627 no 2171 0.378081345599938 2994 688801 SGTC_1022 4477-0945 21.3 µM -0.311220244936432 0.361046176154712 no 2172 0.377816596752149 2953 4648966 SGTC_222 nsc-310342 10.666 µM -0.311639103459993 0.360869375558571 no 2173 0.377657406435018 3035 432556 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.312678717233482 0.360430682086121 no 2174 0.377262383279396 2947 688803 SGTC_2180 6301957 200 µM -0.313373858325277 0.36013745070805 no 2175 0.376998321376864 3089 845462 SGTC_370 0180-0345 38.7 µM -0.314832620131732 0.359522368840254 no 2176 0.376444371481242 2877 3989527 SGTC_2834 9001755 58.44 µM -0.31552685699582 0.359229773922811 no 2177 0.37618083138616 3003 2989575 SGTC_1387 3342-1166 1.8 µM -0.315984992210867 0.359036732231076 no 2178 0.376006949730685 3018 3418228 SGTC_101 0490-5701 117.494 µM -0.316175770530992 0.35895635572396 no 2179 0.375934548725139 2988 4661669 SGTC_1875 nocodazole 6 µM -0.316646771974305 0.358757945607126 no 2180 0.375755820819242 3058 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_63 0099-0242 26.702 µM -0.317191215045424 0.358528645572077 no 2181 0.375549257702499 3114 3898502 YLR359W ADE13 SGTC_2862 9027634 71.43 µM -0.317428412874296 0.35842876223546 no 2182 0.375459275381328 2929 5012562 SGTC_2041 5107442 45.335 µM -0.317807265933729 0.358269248371184 no 2183 0.375315569411 3124 793005 SGTC_249 wiskostatin 11.211 µM -0.317807891445567 0.358268985023528 no 2184 0.375315332157096 3045 2775510 A n-wasp and actin depolymerizer. SGTC_954 1189-0853 2.85 µM -0.318817623604474 0.357843964182637 no 2185 0.374932406712623 2948 2828194 SGTC_1871 st057448 67.3 µM -0.319183424716159 0.357690033036166 no 2186 0.374793712642994 3168 691747 SGTC_1186 1319-0216 26 µM -0.319696666737768 0.357474096952796 no 2187 0.374599143421081 3118 4565136 SGTC_1579 chlormadinone acetate 49.4 µM -0.32200459780492 0.356503646885729 no 2188 0.373724605668631 3115 45114258 A steroidal progestin. SGTC_2821 7996764 71.43 µM -0.323628351192996 0.355821439071358 no 2189 0.373109710506719 3206 2987135 SGTC_1386 3228-0095 33.8 µM -0.323902273139008 0.355706398250462 no 2190 0.373006011485921 3107 870181 SGTC_1449 4112-4002 201 µM -0.324128599817464 0.355611356244303 no 2191 0.372920337614163 3009 2059539 SGTC_2906 7926292 26.41 µM -0.325146214689261 0.355184137323816 no 2192 0.372535206623403 3098 2966319 SGTC_2439 5492030 7.2 µM -0.325552430837684 0.35501364891065 no 2193 0.372381503837964 3080 5722370 SGTC_1364 1653-0028 37.6 µM -0.325851836435165 0.354888007331385 no 2194 0.372268228701984 3025 5718652 SGTC_1958 st076513 41.9 µM -0.326598942782722 0.354574562924534 no 2195 0.371985621632781 2952 732122 YGL099W LSG1 SGTC_340 k038-0059 454 µM -0.327113628809042 0.354358686458735 no 2196 0.371790972036833 2997 23733424 SGTC_1692 fluoroquinolonic acid 71 µM -0.327651087962844 0.354133308120111 no 2197 0.371587744826482 3092 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1077 5-fluorocytosine 377 nM -0.330767915094806 0.35282730597729 no 2198 0.370409899002209 3051 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_376 3970-0862 59.1 µM -0.331199312680213 0.352646679383217 no 2199 0.370246969676791 3104 3135186 SGTC_472 calcifediol 10 µM -0.332172838036871 0.352239185466633 no 2200 0.369879376261827 3036 5283731 A vitamin D metabolite. SGTC_608 k048-0125 159 µM -0.332893855916441 0.351937494285437 no 2201 0.369607203731094 3110 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_485 niflumic acid 177 µM -0.332894108419924 0.351937388648234 no 2202 0.369607108426567 3102 4488 A COX2 inhibitor. SGTC_1357 1503-1303 39.5 µM -0.334632364172604 0.35121044426859 no 2203 0.368951213991126 3018 292895 SGTC_956 1185-0240 191 µM -0.334860569938759 0.351115048197846 no 2204 0.368865133605922 3004 1416193 SGTC_1587 estradiol valerate 56.1 µM -0.336521927946982 0.350420839521696 no 2205 0.368238659349996 3154 13791 A steroid. SGTC_1565 sinapyl alcohol 95.1 µM -0.336686912310382 0.350351927008442 no 2206 0.368176465202719 3093 5280507 A phenol propionate derived from cinnamic acid. SGTC_2497 7-hydroxyflavone 100 µM -0.336924888626233 0.350252535078002 no 2207 0.368086761368515 3160 5281894 SGTC_692 k241-0027 77.8 µM -0.336937287788943 0.350247356790247 no 2208 0.368082087770936 3181 3600480 SGTC_3192 9110362 49.47 µM -0.337479832293295 0.35002080008816 no 2209 0.367877606422186 2982 16649480 SGTC_2786 7743617 45.45 µM -0.337579311564697 0.349979265144869 no 2210 0.367840117418487 3031 583674 SGTC_2533 agelasine 13.65 µM -0.33854145640182 0.349577639666774 no 2211 0.367477595832999 3206 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2782 7736369 71.43 µM -0.339141106475257 0.349327414490367 no 2212 0.367251716479948 3045 2950836 YOL077C BRX1 SGTC_1294 1000-1494 117 µM -0.339320640789875 0.349252510186259 no 2213 0.367184097478487 3033 712797 YDL207W GLE1 SGTC_1812 st052057 4.327 µM -0.339702213007119 0.349093332260092 no 2214 0.367040397507974 2982 3645418 SGTC_3011 9081274 71.4286 µM -0.340044711761287 0.34895047695622 no 2215 0.366911428452249 3010 6625322 SGTC_2386 9075165 157.42 µM -0.340472227164005 0.348772191476326 no 2216 0.366750467168168 2988 16452277 SGTC_3328 9140624 29.0385 µM -0.340493096203272 0.348763489377194 no 2217 0.366742610489694 3154 4904392 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.341121071272408 0.348501669743787 no 2218 0.366506219496497 3100 688664 SGTC_2674 ligustilide 100 µM -0.341505757163782 0.34834131951856 no 2219 0.366361435757672 3090 5319022 A signalling regulator. SGTC_500 h-89 112 µM -0.342395053317742 0.347970734278626 no 2220 0.366026805334148 3172 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_467 ro 31-8220 72.8 µM -0.342656693543324 0.347861731847278 no 2221 0.365928372950447 3034 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2262 9014885 67.46 µM -0.344149976526972 0.347239853272475 no 2222 0.365366749965521 2991 6457424 SGTC_173 1273-0061 2.693 µM -0.344988918654899 0.346890655560706 no 2223 0.365051350772641 3111 2847414 YPL266W DIM1 SGTC_643 k048-0106 28.4 µM -0.345291622845079 0.346764691153547 no 2224 0.364937571926423 3097 6763920 SGTC_1665 st014639 11.4 µM -0.346108476401601 0.346424858131749 no 2225 0.364630596710766 3044 981133 YIL048W NEO1 SGTC_2304 7443016 91.4 µM -0.346120924644041 0.346419680283833 no 2226 0.364625919306943 2946 939854 SGTC_1719 st032227 49.2 µM -0.346905401286735 0.346093435059706 no 2227 0.364331194354619 3009 3125804 SGTC_728 3030-5151 22.5 µM -0.347166030355574 0.345985070873961 no 2228 0.364233294724188 3010 3125388 SGTC_1888 azatryptophan 97.5 µM -0.347759940276757 0.345738182519292 no 2229 0.364010238503406 3116 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1900 st060200 72.8 µM -0.348623237572092 0.345379426811863 no 2230 0.363686089962439 2998 688945 SGTC_395 anisomycin 6.25 µM -0.349821814443943 0.344881571103716 no 2231 0.363236213318876 3074 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1732 st034308 51.822 µM -0.353173738589619 0.343490701890893 no 2232 0.361979097246877 2918 830119 SGTC_1830 st055982 50.3 µM -0.354239178372485 0.343049043775241 no 2233 0.361579822315532 3145 455313 An antimicrobial agent. SGTC_279 1273-0055 2.93 µM -0.354459907613468 0.342957571383419 no 2234 0.361497122575197 3091 2847562 SGTC_427 1354-0053 47.3 µM -0.358241559296214 0.341391850852417 no 2235 0.36008127422633 3227 6813657 SGTC_2773 thioridazine 9.09 µM -0.359489401958854 0.340875802294638 no 2236 0.359614502344281 3080 5452 An antipsychotic. SGTC_2962 9082311 13.18 µM -0.359716092747111 0.340782085648674 no 2237 0.359529728138484 2989 16459453 SGTC_741 4582-0002 126 µM -0.36112561244043 0.340199594266684 no 2238 0.359002773704603 3023 2912688 SGTC_992 3909-8734 162 µM -0.361238079602154 0.340153133025447 no 2239 0.358960738957566 3072 4288319 SGTC_680 0417-1641 114 µM -0.362286242191544 0.339720244002422 no 2240 0.358569069018916 3011 2835990 SGTC_806 3966-4455 5.86 µM -0.362782183238659 0.33951549496613 no 2241 0.358383801098991 3056 714982 SGTC_1212 0520-0165 585 µM -0.366283394628605 0.338071371784839 no 2242 0.357076809552406 3436 5403258 SGTC_3308 9128332 17.569 µM -0.367601995951457 0.337528112054937 no 2243 0.356585013165445 3205 17332805 YDL196W YDL196W SGTC_155 k072-0202 43.6 µM -0.368397442969129 0.337200553889064 no 2244 0.356288451910576 3134 5857737 SGTC_3102 9121669 49.47 µM -0.368514161375241 0.33715250063811 no 2245 0.356244943865047 3068 41905072 SGTC_2203 7227154 166.4 µM -0.37031045605059 0.336413297259803 no 2246 0.35557559196403 3100 896304 SGTC_2993 9054257 71.4286 µM -0.370423149072431 0.336366943352044 no 2247 0.355533614068483 3015 6470217 YGL055W OLE1 SGTC_10 0279-0212 42.575 µM -0.37049592879632 0.33633700826292 no 2248 0.355506504717313 3067 39851 YBR002C RER2 SGTC_1881 5652484 16 µM -0.372170274595059 0.335648618523702 no 2249 0.3548830382203 3186 2255129 SGTC_2730 imipramine 71.33 µM -0.372794485437612 0.335392121700504 no 2250 0.354650703732496 3097 3696 A tricyclic antidepressant. SGTC_1225 1216-0074 20.6 µM -0.37350712238541 0.335099383153479 no 2251 0.354385522685624 3081 4241466 SGTC_2086 5274770 176.623 µM -0.374227027290889 0.33480376072738 no 2252 0.354117708800449 3129 689278 SGTC_3209 9113616 49.47 µM -0.374301248643943 0.334773288218226 no 2253 0.354090101602613 3271 16649353 SGTC_2938 9059746 27.26 µM -0.374726217233463 0.334598832978289 no 2254 0.353932046068748 3167 6471769 SGTC_1940 st075990 51.1 µM -0.374884147007236 0.334534009809865 no 2255 0.353873314788507 3317 1084979 SGTC_1321 1326-2144 215 µM -0.37547510353187 0.33429149213599 no 2256 0.353653579402618 3166 3513030 SGTC_445 e6 berbamine 66 µM -0.375647024120719 0.334220952073335 no 2257 0.353589663315334 3152 6610268 A calcium/calmodulin antagonist. SGTC_2952 9073731 13.78 µM -0.37614647199492 0.334016058791489 no 2258 0.353404003599768 3087 16457353 SGTC_1857 st056007 79.3 µM -0.376868350093939 0.333720003254745 no 2259 0.35313572155859 3143 619834 SGTC_204 PMA1.184 62.41 µM -0.378746462586816 0.332950239927568 no 2260 0.352438073556198 3081 2252213 YGL008C PMA1 SGTC_3178 9107506 49.47 µM -0.381241031400842 0.331928903730249 no 2261 0.351512202668964 3214 8897194 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.382024316008803 0.331608465273946 no 2262 0.351221664252513 3037 2333 A French combination drug. SGTC_2951 9072950 58.06 µM -0.384049782029452 0.330780427210954 no 2263 0.350470775343157 3128 16488155 SGTC_2000 st075254 36.4 µM -0.384095917025709 0.330761576218858 no 2264 0.350453678782883 3097 17234175 SGTC_1434 4073-0095 163 µM -0.384474620501531 0.330606852294312 no 2265 0.350313351505369 3171 24133745 SGTC_2762 leflunomide 42.06 µM -0.384994763296563 0.33039438879076 no 2266 0.3501206476764 3065 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1809 st050081 57.6 µM -0.386126246538657 0.329932398994459 no 2267 0.349701586202663 3247 5036894 SGTC_1728 st035614 33.7865 µM -0.386207258864533 0.329899331228605 no 2268 0.349671589111957 3122 15945546 SGTC_711 k292-0785 179 µM -0.386985000525671 0.329581938819863 no 2269 0.349383656180666 3065 4146315 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.387198276342561 0.329494923475607 no 2270 0.349304713049079 3108 4620898 SGTC_1833 st055984 71 µM -0.387383510253351 0.329419356563111 no 2271 0.349236154798547 3107 676288 SGTC_714 4296-0578 26.1 µM -0.387610484117685 0.329326771167965 no 2272 0.349152154581787 3074 1589775 SGTC_901 1112-0062 60.1 µM -0.387742298576332 0.329273007252621 no 2273 0.349103375074528 3091 1908457 SGTC_828 2074-0507 139 µM -0.388178347744143 0.329095178550524 no 2274 0.34894202766537 3218 X828 SGTC_594 1487-1584 10.8 µM -0.390215492939549 0.328264906900248 no 2275 0.348188603107037 3094 5013332 SGTC_457 grayanotoxin iii 135 µM -0.391454891587029 0.327760184233648 no 2276 0.347730512535932 3196 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_225 nsc-122657 1.016 µM -0.392674025676039 0.327264020736237 no 2277 0.347280128664323 3190 275685 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.392940406258397 0.327155649678574 no 2278 0.347181748543765 3077 803109 SGTC_262 fenpropimorph 62.5 µM -0.393511154693494 0.32692350234414 no 2279 0.346970993455188 3144 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2865 9030313 51.95 µM -0.393687594431235 0.326851750447084 no 2280 0.34690585073092 3058 42562754 SGTC_3319 9138450 16.7555 µM -0.393740258808467 0.326830334919325 no 2281 0.34688640756947 3077 2029690 SGTC_1623 st003709 20.3 µM -0.394119097983878 0.326676299956294 no 2282 0.346746555818247 3082 16192618 SGTC_2537 larixol 68.93 µM -0.394660362389421 0.326456274599603 no 2283 0.346546779622016 3171 6708759 SGTC_537 1334-0398 209 µM -0.39508017526426 0.326285661161748 no 2284 0.346391859557376 3248 5846986 SGTC_2673 kobusone 100 µM -0.395198615054488 0.32623753338375 no 2285 0.346348157349356 3116 6710676 An epoxy ketone and protein crosslinker. SGTC_879 0831-1030 162 µM -0.395375808823872 0.32616553644352 no 2286 0.346282779771608 3120 1549252 SGTC_366 0181-0206 4.31 µM -0.395378301735538 0.326164523575939 no 2287 0.346281860017271 3294 274874 SGTC_3168 9103419 49.47 µM -0.395765663779194 0.326007154339223 no 2288 0.34613895465144 3166 16649256 SGTC_334 1502-1024 68.5 µM -0.397195757890452 0.325426434573009 no 2289 0.345611555085394 3200 3296216 SGTC_3041 9091929 49.47 µM -0.397195948565648 0.325426357173551 no 2290 0.345611484786882 3278 25236887 SGTC_2011 4012611 177 µM -0.397240505582981 0.325408270659224 no 2291 0.34559505756279 3067 2049887 SGTC_1430 4049-0248 69.1 µM -0.398268766836384 0.324990994775823 no 2292 0.345216040355574 3205 22774488 SGTC_694 1315-0438 43.2 µM -0.399254689391574 0.324591106291805 no 2293 0.344852774924581 3133 6793154 SGTC_363 0455-0021 3.06 µM -0.400266136266512 0.324181075222392 no 2294 0.344480253567245 3077 4597466 SGTC_52 0329-0193 875 nM -0.40220039813739 0.323397537510772 no 2295 0.343768274622308 3301 3739292 SGTC_2432 5630864 12.22 µM -0.404007493415507 0.322666219794373 no 2296 0.343103604425006 3231 5714970 SGTC_2932 9016711 44.54 µM -0.4041519150872 0.322607802984278 no 2297 0.343050505400428 3246 7117328 SGTC_3304 9125678 46.087 µM -0.404918736858378 0.322297706273331 no 2298 0.342768622585593 3112 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3030 9087619 49.47 µM -0.405705278452483 0.321979763450265 no 2299 0.342479581703209 3153 25236973 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.405716411927408 0.321975263912695 no 2300 0.342475490998929 3241 5282362 SGTC_1124 fisetin 1.16336 µM -0.406471438762569 0.32167018456497 no 2301 0.34219811926653 3165 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2749 bexarotene 57.39 µM -0.406590051713127 0.32162226823332 no 2302 0.342154552548159 3174 82146 An retinoic acid receptor inhibitor. SGTC_1089 terbinafine 2.25 µM -0.406881815994714 0.321504416209412 no 2303 0.342047396022161 3218 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3103 9120822 49.47 µM -0.407009939088132 0.321452669265473 no 2304 0.342000344159146 3352 17141819 SGTC_2593 nobiletin 86.24 µM -0.407866092319078 0.321106971139319 no 2305 0.341685993867929 3171 72344 An anti-infammatory. SGTC_1657 st012939 43.4 µM -0.409065995580197 0.320622734244568 no 2306 0.341245615017971 3248 24207257 SGTC_1226 3909-7979 35.4 µM -0.409847614391266 0.32030746564632 no 2307 0.340958867765066 3233 6615510 SGTC_2063 5246145 200 µM -0.410831733508934 0.319910702268251 no 2308 0.340597961217615 3235 711240 SGTC_2947 9072639 7.68 µM -0.41109032623061 0.319806480618406 no 2309 0.340503151557759 3206 16488146 SGTC_2846 9008642 19.48 µM -0.411413811249114 0.319676125195833 no 2310 0.340384564170578 3225 2992898 SGTC_1514 1189-1591 158 µM -0.412256158137973 0.319336787481896 no 2311 0.340075839660415 3294 767698 YMR146C TIF34 SGTC_1664 st014217 9.02 µM -0.413078841046775 0.319005517364462 no 2312 0.339774425565406 3242 3982782 SGTC_1129 3453-1384 223 µM -0.413633940459353 0.318782076852006 no 2313 0.339571106413218 3301 1084452 SGTC_2349 9023730 187.07 µM -0.413997154010065 0.318635910531688 no 2314 0.339438095555225 3277 4126287 SGTC_432 NS 1619 61.3 µM -0.414333310780641 0.318500657683989 no 2315 0.339315010862979 3270 4552 A K+/calcium channel activator. SGTC_3016 9080866 49.47 µM -0.414547202389037 0.318414610874449 no 2316 0.339236702806828 3122 17066299 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.414591467756728 0.318396804509453 no 2317 0.339220497638831 3152 2346 DNA damaging agent; causes G2/M arrest. SGTC_374 0880-0231 82.3 µM -0.414765535375438 0.318326787437311 no 2318 0.339156775874535 3175 6833587 SGTC_3247 9135149 49.47 µM -0.415132106965342 0.318179358668172 no 2319 0.339022598309321 3157 8934436 YOR116C RPO31 SGTC_1230 0170-0365 3.77 µM -0.415405809144496 0.318069299152046 no 2320 0.338922427393195 3279 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_978 1416-0512 87.4 µM -0.415642766220983 0.31797402833444 no 2321 0.338835713834239 3230 6814003 SGTC_1046 2001-0062 216 µM -0.41652601769848 0.317619014954364 no 2322 0.338512566523926 3106 739778 SGTC_1748 st037455 53.6035 µM -0.416900795439959 0.317468427732659 no 2323 0.338375485853025 3298 580690 SGTC_2729 fluphenazine 10.66 µM -0.41766327406141 0.317162153968249 no 2324 0.338096663801781 3118 3372 An atypical antipsychotic. SGTC_2662 daunorubicin 22.37 µM -0.41887275670679 0.316676583684064 no 2325 0.337654564141895 3156 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2705 st078069 42.8 µM -0.421038835821229 0.315807758575933 no 2326 0.336863361734626 3204 1530061 SGTC_1852 st056254 31.4 µM -0.421314837412974 0.315697125894789 no 2327 0.336762598542323 3127 442583 SGTC_1995 st072814 61.1 µM -0.421495660720754 0.315624653499212 no 2328 0.336696589573235 3137 5769371 SGTC_2855 9016525 58.44 µM -0.421846232158949 0.315484167740986 no 2329 0.336568628926058 3126 43811474 SGTC_2560 caryophyllene 100 µM -0.422842054596128 0.31508525372888 no 2330 0.33620525110916 3138 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2866 9034245 58.44 µM -0.423431057156475 0.314849408094151 no 2331 0.335990394748898 3179 6462273 SGTC_944 3370-0224 231 µM -0.42506656763395 0.314194920745423 no 2332 0.335394074352046 3171 4580514 SGTC_1769 st044406 64.4 µM -0.425733981480506 0.313928007266944 no 2333 0.335150848834694 3128 670903 SGTC_1557 sumaresinolic acid 42.3 µM -0.426491537257153 0.313625161980821 no 2334 0.334874856643488 3139 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1149 3909-7961 23.3 µM -0.426698292682021 0.313542529927832 no 2335 0.334799547133089 3183 735261 SGTC_3108 9121785 49.47 µM -0.427676580375948 0.313151673538215 no 2336 0.334443301428728 3220 17140271 SGTC_2939 9044578 71.43 µM -0.427748154058177 0.313123085856619 no 2337 0.334417243555133 3107 2653634 SGTC_3347 9188721 44.724 µM -0.428053241438431 0.313001241642769 no 2338 0.334306179157908 3223 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3337 9144342 33.5465 µM -0.428264831537588 0.312916749878915 no 2339 0.334229160146442 3241 17682949 SGTC_656 4090-1979 187 µM -0.429231279220522 0.312530954780246 no 2340 0.333877460985315 3294 22330961 SGTC_1204 4049-0315 18.3 µM -0.429278674054752 0.31251204057177 no 2341 0.333860217321007 3355 588402 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.430250427791281 0.312124344519749 no 2342 0.333506741506775 3231 75037 A free radical scavenger. SGTC_2525 harmine 47.85 µM -0.431810300783108 0.311502444274367 no 2343 0.332939646143824 3167 5280953 A monoamine oxidase inhibitor SGTC_2553 4-methylesculetin 85.09 µM -0.432493091484754 0.311230393856051 no 2344 0.332691536123131 3220 5319502 SGTC_6 0844-0013 19.835 µM -0.433502297515473 0.310828475656297 no 2345 0.332324948665154 3289 1584900 SGTC_17 0960-0276 49.807 µM -0.43507268432255 0.310203514907765 no 2346 0.331754834966096 3170 6821114 SGTC_1622 st003707 19.4 µM -0.435270328963085 0.31012489780829 no 2347 0.33168310956035 3269 10140899 SGTC_1667 st014849 34.6 µM -0.435809549164101 0.309910456357684 no 2348 0.331487457483954 3207 5348460 SGTC_2878 9043973 25.97 µM -0.436131510164884 0.309782447125974 no 2349 0.331370658223978 3302 6465167 SGTC_1651 st011928 86.1 µM -0.436360817712669 0.309691290260029 no 2350 0.331287481278383 3264 720198 SGTC_896 0964-0007 44.5 µM -0.437057925451683 0.309414240190603 no 2351 0.331034669845326 3270 6756758 SGTC_1136 pergolide 1.05886 µM -0.437722328647748 0.309150288605739 no 2352 0.3307937906416 3128 47811 A dopamine receptor agonist. SGTC_581 0958-0271 211 µM -0.437761032455656 0.30913491553793 no 2353 0.330779760744384 3193 4591145 SGTC_3298 9116858 71.43 µM -0.438988036429228 0.308647725604743 no 2354 0.330335102506188 3289 2506942 SGTC_1229 0139-0193 12.2 µM -0.440186371763876 0.308172243623465 no 2355 0.329901064711394 3313 3090752 SGTC_1170 0310-0127 64.8 µM -0.44075159146673 0.307948084302309 no 2356 0.329696421198406 3225 774975 SGTC_349 k015-0014 24 µM -0.440789106960336 0.307933208644189 no 2357 0.329682840137702 3114 2196908 SGTC_1575 cyproterone acetate 48 µM -0.44250576609097 0.307252856258505 no 2358 0.329061629351933 3204 9880 An androgen receptor antagonist and liver toxin. SGTC_2639 lactacystin 53 µM -0.44465210542556 0.306403144062939 no 2359 0.328285593118697 3325 3870 A proteasome inhibitor. SGTC_3085 9117376 49.47 µM -0.445779315028902 0.305957310326024 no 2360 0.327878332471927 3284 16480349 SGTC_2677 mitomycin C 100 µM -0.446200707308974 0.305790715079265 no 2361 0.327726136025467 3228 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2018 5133068 143 µM -0.44773501843882 0.305184472850973 no 2362 0.327172222802614 3155 785362 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.447777364283777 0.305167748583392 no 2363 0.327156940599326 3185 4330530 SGTC_97 0535-0701 19.132 µM -0.44794822248448 0.30510027317273 no 2364 0.3270952824812 3216 2832013 YGL099W LSG1 SGTC_310 1273-0058 1.06 µM -0.450230389336788 0.304199634563648 no 2365 0.326272163026443 3289 2734232 SGTC_1487 3970-0795 2.82 µM -0.451021055434652 0.30388788108535 no 2366 0.325987186895053 3288 3765103 SGTC_1080 nisoldipine 24.4 µM -0.451763348792296 0.303595330356598 no 2367 0.32571973799662 3142 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2732 terfenadine 20 µM -0.452102169151908 0.303461837168774 no 2368 0.325597690546083 3241 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_236 1509-0011 5.31 µM -0.452543131337489 0.303288139996019 no 2369 0.325438878294767 3361 3107280 SGTC_2222 6885208 172.143 µM -0.4531265225347 0.30305840765398 no 2370 0.325228819023751 3234 609514 SGTC_1704 st028805 70.8 µM -0.453496329132663 0.302912822652 no 2371 0.325095693030345 3267 2876101 SGTC_1902 st060212 70.5 µM -0.453931972114701 0.302741359438153 no 2372 0.32493889535932 3322 688944 SGTC_39 0986-0283 58.349 µM -0.454427483842027 0.302546385555211 no 2373 0.324760587274604 3384 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_5 0352-0601 109.883 µM -0.454572835078431 0.302489203450204 no 2374 0.32470829077697 3242 762456 SGTC_1764 st044502 93.5 µM -0.45550513686022 0.302122545245572 no 2375 0.32437293641785 3314 8407 SGTC_2029 5175081 200 µM -0.455947562186043 0.301948616837524 no 2376 0.324213843264226 3214 1380876 SGTC_588 3970-1144 52.9 µM -0.455999001589014 0.301928397647095 no 2377 0.32419534808486 3274 1888707 SGTC_2068 5226020 147 µM -0.456039901768016 0.301912321523938 no 2378 0.324180642622171 3233 1810509 SGTC_306 1672-3436 11.6 µM -0.457836479882847 0.301206542809671 no 2379 0.323534962513994 3294 6797378 SGTC_3190 9110366 49.47 µM -0.457870836732932 0.301193053099981 no 2380 0.32352262002253 3280 17123768 SGTC_2761 levamisole 97.89 µM -0.45788631549969 0.301186975679786 no 2381 0.323517059432241 3345 26879 An alkaline phosphatase inhibitor. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.458378786479384 0.300993645900526 no 2382 0.323340164796669 3315 368090 SGTC_1864 st057645 30.4 µM -0.45927819169984 0.300640710046888 no 2383 0.323017203229942 3306 688666 SGTC_1295 1013-0063 9.78 µM -0.459913909429581 0.300391360617992 no 2384 0.322789007931978 3340 6826038 SGTC_2001 4023502 57.655 µM -0.46141525902072 0.299802853119203 no 2385 0.322250352995825 3277 108941 YCR052W RSC6 SGTC_1839 st053978 48 µM -0.461715185204812 0.299685348949728 no 2386 0.322142790005974 3291 3788398 SGTC_1675 st018485 24.5 µM -0.461964132258011 0.299587833076838 no 2387 0.32205352105217 3226 3323024 SGTC_462 ag-879 158 µM -0.462185200250828 0.299501249858534 no 2388 0.321974257747526 3290 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3104 9120930 49.47 µM -0.464873606692356 0.298449220915174 no 2389 0.321010986181039 3308 17014836 SGTC_1479 0549-0158 134 µM -0.465374653112319 0.298253337152309 no 2390 0.320831591198379 3272 5440202 SGTC_1696 st025591 34.7925 µM -0.465504240888463 0.298202684428139 no 2391 0.320785200313821 3224 2787147 SGTC_219 mitoxanthrone 164.414 µM -0.467850236967095 0.297286369670254 no 2392 0.319945846083753 3261 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1558 st069300 45.6 µM -0.469903659654894 0.296485387708301 no 2393 0.319211924772787 3312 24208000 SGTC_2015 5119600 184 µM -0.469944461477786 0.296469482099502 no 2394 0.319197348808148 3361 2828786 SGTC_1971 st069429 63.5 µM -0.470004032662397 0.296446260408996 no 2395 0.319176068214785 3312 1246522 YGL099W LSG1 SGTC_2312 7706453 155.7 µM -0.470376105863427 0.296301239879419 no 2396 0.319043166120551 3216 976098 SGTC_1105 epirubicin 18.1 µM -0.470965330224618 0.296071648345045 no 2397 0.318832746648769 3207 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.471656722995688 0.295802351002553 no 2398 0.318585915996945 3280 3256 An antibiotic and ribosome inhibitor. SGTC_2882 9058044 58.44 µM -0.472095920364873 0.295631342181209 no 2399 0.31842916214873 3291 18076804 SGTC_3090 9117696 49.47 µM -0.477142254956906 0.293669736895799 no 2400 0.316630413618782 3257 7923821 SGTC_2670 beta-carotene 100 µM -0.477568432297206 0.293504349985255 no 2401 0.316478701776014 3313 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2193 5925765 200 µM -0.477755675564403 0.293431700014255 no 2402 0.316412056137069 3325 877370 SGTC_2800 7887935 81.82 µM -0.477831687075308 0.293402210094707 no 2403 0.316385003003186 3350 2961002 SGTC_917 harmaline 728.087 nM -0.477896504129569 0.293377064334006 no 2404 0.316361934846422 3291 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1519 esterone 74 µM -0.478792844577157 0.293029431701774 no 2405 0.31604300379749 3192 698 A steroid. SGTC_1205 4161-2785 76 µM -0.479222065608808 0.292863032246304 no 2406 0.315890329114704 3319 3498106 SGTC_1366 1683-0113 21.9 µM -0.480277031020008 0.292454232101796 no 2407 0.315515209526758 3241 708623 SGTC_1919 st067113 52.3 µM -0.480932059673713 0.292200541402591 no 2408 0.315282393147892 3345 1268243 SGTC_401 neomycin 50 µM -0.481741120242747 0.291887335998948 no 2409 0.314994930545627 3275 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_903 1134-0042 114 µM -0.482309294830078 0.291667476442463 no 2410 0.314793122687028 3262 701009 SGTC_438 sphingosine 6.67 µM -0.482439352402265 0.291617160517131 no 2411 0.314746935787975 3180 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2534 helenine 20.12 µM -0.482767249363392 0.291490323592783 no 2412 0.314630503730356 3268 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3258 9138477 49.47 µM -0.486912197837658 0.289889199874863 no 2413 0.313160277189833 3305 4970355 SGTC_840 0245-0196 390 µM -0.487082218573426 0.289823611891075 no 2414 0.313100033445999 3402 3827528 SGTC_2106 5357045 167.29 µM -0.48913919261236 0.28903065622577 no 2415 0.312371577923105 3306 668842 SGTC_2531 methyl deoxycholate 70.07 µM -0.489331686476075 0.288956502823646 no 2416 0.312303445712959 3202 16667744 Haematoxylin. SGTC_300 r073-0011 5.04 µM -0.489333313495895 0.288955876093481 no 2417 0.312302869865033 3373 2735780 SGTC_1066 ketoconazole 628 nM -0.490204860341113 0.288620247078651 no 2418 0.3119944709328 3377 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2380 9035439 200 µM -0.494062856716918 0.287136758959061 no 2419 0.31063089432751 3403 6462575 SGTC_2986 9022445 71.43 µM -0.494871297150771 0.286826353160975 no 2420 0.31034548636545 3379 6459286 SGTC_1342 1486-1464 234 µM -0.494913786422953 0.286810043537036 no 2421 0.310330489311513 3271 3253938 SGTC_1741 st038134 10.228 µM -0.495100027432857 0.286738559599766 no 2422 0.310264757228392 3472 1272587 SGTC_1712 st032288 53.4 µM -0.495163696013509 0.286714123950534 no 2423 0.310242287367666 3372 2883011 SGTC_1594 piperine 70.1 µM -0.495511897278082 0.286580503698008 no 2424 0.310119413009416 3261 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2261 9010538 184.68 µM -0.496464382705843 0.286215143827404 no 2425 0.309783405291821 3337 6457250 SGTC_1556 plumbagin 1.48 µM -0.49755442313223 0.285797291455288 no 2426 0.309399067312798 3336 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3174 9107204 49.47 µM -0.49792041507763 0.285657058441599 no 2427 0.309270068716942 3392 3938802 SGTC_71 0417-1750 47.813 µM -0.498190493894285 0.285553596380459 no 2428 0.30917489101638 3398 6811472 SGTC_1615 st002656 86.5 µM -0.499073389332313 0.285215500435126 no 2429 0.30886384174993 3382 1584458 SGTC_1489 4065-0444 182 µM -0.499336348843735 0.285114839609708 no 2430 0.308771226039592 3364 2877968 SGTC_1164 k060-0068 93.7 µM -0.499788018855972 0.28494197999403 no 2431 0.30861217389141 3340 5963676 SGTC_1024 4507-0395 26 µM -0.500721489604598 0.284584887855826 no 2432 0.308283573085769 3430 4201836 SGTC_2282 7944268 200 µM -0.501646910700192 0.28423108612992 no 2433 0.307957957496609 3446 2970414 SGTC_1709 st033179 39.1045 µM -0.502281528217175 0.283988584386184 no 2434 0.307734750428449 3304 573381 SGTC_2072 5231554 129 µM -0.502386837947201 0.283948352729176 no 2435 0.307697717870567 3412 789545 SGTC_1645 Cervolide 78 µM -0.502595494752955 0.283868647267981 no 2436 0.307624348716436 3342 23173 A fragrance. SGTC_3256 9138902 49.47 µM -0.504595191143434 0.283105320677752 no 2437 0.306921594049326 3331 17228773 SGTC_1178 0988-0033 191 µM -0.504915475084305 0.282983153070851 no 2438 0.306809102240558 3380 5392207 SGTC_2091 4-phenylthiadiazole 200 µM -0.505469766117561 0.282771786714721 no 2439 0.30661446421684 3265 270010 SGTC_2107 5363541 170.161 µM -0.505895140754101 0.282609631165587 no 2440 0.306465131865526 3374 244052 SGTC_70 0141-0289 43.283 µM -0.506004962799019 0.282567773555862 no 2441 0.306426582870848 3305 352408 SGTC_1441 4106-0040 13 µM -0.506466115400356 0.282392042244441 no 2442 0.306264735576965 3348 2904180 SGTC_831 k061-1017 217 µM -0.507085658454365 0.282156035907651 no 2443 0.306047358668599 3353 1240153 SGTC_331 k048-0133 24.5 µM -0.508493983393002 0.281619907554887 no 2444 0.305553478731805 3299 6813582 SGTC_3115 9123671 49.47 µM -0.508767774004052 0.281515736606592 no 2445 0.305457505204127 3427 3286988 SGTC_774 k060-0086 136 µM -0.508860770301587 0.281480357911789 no 2446 0.305424909674021 3432 5911235 SGTC_1730 st033808 45.1 µM -0.509020385562036 0.281419640284657 no 2447 0.305368967558353 3247 1045166 SGTC_397 arbidol 50 µM -0.509184473963811 0.281357227664162 no 2448 0.30531146242947 3403 131410 A RNA synthesis inhibitor. SGTC_273 hydroxyurea 18.1 mM -0.510368646463852 0.280907014315047 no 2449 0.304896609176534 3314 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1318 1280-3875 124 µM -0.51155842136194 0.280455021965534 no 2450 0.304480045654585 3354 373245 SGTC_1862 st057513 3.81 µM -0.512531697477773 0.280085538922163 no 2451 0.304139471056346 3260 5393163 SGTC_2181 6316240 54.2555 µM -0.512748586480258 0.280003233900593 no 2452 0.304063599093426 3356 12779990 SGTC_2471 5466956 24.79 µM -0.513484363017067 0.279724108868976 no 2453 0.30380627312367 3260 724419 SGTC_134 0269-0018 6.916 µM -0.513832245326333 0.279592182863355 no 2454 0.303684640737565 3326 4378915 SGTC_2887 9044784 58.44 µM -0.514125971490158 0.279480817797009 no 2455 0.303581960248402 3346 6465546 SGTC_2406 ethylparaben 405.7 µM -0.515191218854547 0.279077114462647 no 2456 0.303209702303055 3140 8434 A possible steroid mimic. SGTC_3276 9139060 49.47 µM -0.517087016533839 0.2783593545088 no 2457 0.302547708277923 3383 4870619 SGTC_1038 k292-0204 154 µM -0.517609778382893 0.278161592224805 no 2458 0.302365278963256 3334 4454212 SGTC_838 0109-0203 71.4 µM -0.518001989928673 0.278013262493986 no 2459 0.302228440470268 3363 759422 SGTC_1963 st076565 50.3 µM -0.518209637472832 0.277934748296472 no 2460 0.302156005674275 3323 4914280 SGTC_887 0885-0007 9.62 µM -0.518359727053474 0.277878004241395 no 2461 0.302103653981093 3393 5719458 SGTC_347 4534-1311 26.2 µM -0.519255982370581 0.27753927662188 no 2462 0.301791122259916 3365 2862016 SGTC_2031 5180455 200 µM -0.520457510188135 0.27708549218174 no 2463 0.301372367641624 3341 29949 SGTC_2164 5685496 200 µM -0.521809482104103 0.276575323623812 no 2464 0.300901493503758 3423 759046 SGTC_2610 ononetin 44.17 µM -0.522882905086215 0.276170594096935 no 2465 0.30052787077973 3366 259632 SGTC_2168 5727979 200 µM -0.523516143808723 0.275931970559902 no 2466 0.300307559806429 3355 695210 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.523770368594212 0.275836199457084 no 2467 0.300219132643725 3493 6710655 SGTC_2844 9010103 25.97 µM -0.525831525488676 0.275060327703872 no 2468 0.299502634236032 3433 2480525 SGTC_1666 st014829 29 µM -0.526363897268576 0.274860104278188 no 2469 0.299317697437535 3370 3858230 SGTC_3291 9121177 71.43 µM -0.526412189481333 0.274841945276457 no 2470 0.299300924116312 3323 17015612 SGTC_706 4262-0057 46.9 µM -0.526685831419752 0.274739060676003 no 2471 0.29920588818998 3342 883298 SGTC_2818 7996756 12.99 µM -0.52724581022818 0.274528577611874 no 2472 0.299011450080327 3312 2241621 SGTC_3154 9100113 49.47 µM -0.527394903660023 0.274472550258576 no 2473 0.298959690928911 3315 25237525 SGTC_2418 pentamidine 31.67 µM -0.529185299749284 0.273800183985794 no 2474 0.298338456627333 3416 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2394 5221648 200 µM -0.529474171858791 0.273691777164269 no 2475 0.298238278433134 3419 788586 SGTC_740 k014-0057 261 µM -0.530504297281138 0.273305368582025 no 2476 0.297881165174087 3396 4012779 SGTC_1964 st076914 61 µM -0.530741926226142 0.273216270365487 no 2477 0.297798814106198 3400 24208661 SGTC_926 2268-1401 59.4 µM -0.53132849963733 0.272996398153507 no 2478 0.29759557968717 3413 2931578 SGTC_2199 6590217 200 µM -0.531360061247605 0.272984570031359 no 2479 0.297584646098156 3352 703109 SGTC_1152 3909-8331 15.9 µM -0.531421705997386 0.272961468595922 no 2480 0.297563291621538 3332 16001939 SGTC_1393 3470-5649 58.2 µM -0.532126510782308 0.272697411171786 no 2481 0.297319188573436 3350 4108395 SGTC_3197 9113331 49.47 µM -0.532373562684785 0.272604882379336 no 2482 0.297233645942407 3487 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_623 k072-0108 16.9 µM -0.534495969207751 0.271810616273468 no 2483 0.296499218736308 3385 5382803 SGTC_2687 chenodiol 100 µM -0.534927349534912 0.271649322165919 no 2484 0.296350047734276 3433 5702181 A cholesterol synthesis inhibitor. SGTC_1463 k081-0032 34.1 µM -0.536313224965108 0.271131462791098 no 2485 0.29587104602675 3349 977755 SGTC_2853 9015042 58.44 µM -0.536425087420634 0.2710896846852 no 2486 0.295832398392194 3287 6457456 SGTC_3184 9108758 49.47 µM -0.536626091799287 0.271014622148747 no 2487 0.295762958723196 3392 902885 SGTC_130 0136-0219 337.655 µM -0.537143645988524 0.270821395829255 no 2488 0.295584197134599 3369 234244 SGTC_950 1165-0508 94.1 µM -0.537266328639907 0.270775602946853 no 2489 0.295541830216747 3385 6148369 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.538098317855257 0.27046515426938 no 2490 0.295254586861448 3387 6708739 YPR165W RHO1 SGTC_2191 5911152 200 µM -0.538739026215816 0.270226201464337 no 2491 0.295033470629625 3380 2875902 SGTC_2780 5215298 71.43 µM -0.539619894753696 0.269897853122821 no 2492 0.294729596796041 3455 2834131 SGTC_1313 1220-0047 237 µM -0.540763459058243 0.269471881708961 no 2493 0.294335316072837 3389 3528706 SGTC_2070 5230947 200 µM -0.541012118088647 0.269379302210186 no 2494 0.294249615092279 3473 2835538 SGTC_2457 5731572 11.68 µM -0.542736775170527 0.268737625618266 no 2495 0.293655525024048 3440 2865357 SGTC_909 3448-9333 149 µM -0.543546020047624 0.268436802551387 no 2496 0.293376957156011 3359 3344074 SGTC_1891 st059073 26.2 µM -0.544034918611005 0.268255144879274 no 2497 0.293208722047985 3472 688754 SGTC_1390 3413-2614 145 µM -0.545917076357805 0.267556378501015 no 2498 0.292561469807967 3412 3421432 SGTC_2137 5261020 140 µM -0.546051677399422 0.267506441952401 no 2499 0.292515207518255 3389 763655 SGTC_171 k064-0041 9.68 µM -0.546196642882319 0.267452665486744 no 2500 0.292465386779803 3348 53325 SGTC_1810 st050138 53 µM -0.546939788272442 0.267177073556194 no 2501 0.29221004965018 3439 3444541 SGTC_642 0335-0876 158 µM -0.547033950681931 0.267142164109461 no 2502 0.292177703817244 3416 6812350 SGTC_870 0573-2213 57.6 µM -0.547236151031557 0.267067208831481 no 2503 0.292108251382968 3450 3916321 SGTC_2239 6685329 187.64 µM -0.547517726349196 0.26696284709986 no 2504 0.292011547778357 3436 805680 SGTC_2062 5245942 200 µM -0.551117390663134 0.265630502128572 no 2505 0.290776602333678 3489 1376160 SGTC_2918 7977171 22.06 µM -0.551987814776073 0.265308838782356 no 2506 0.290478350894299 3407 2236483 SGTC_161 4065-0411 162.148 µM -0.552293804599605 0.265195807895873 no 2507 0.290373537290345 3402 1906281 YLR208W SEC13 SGTC_1015 4130-4525 82 µM -0.552570438861733 0.265093641836064 no 2508 0.290278794370133 3340 1363237 SGTC_2480 5767542 37.17 µM -0.553081032882512 0.264905122705305 no 2509 0.290103961916644 3399 2867358 SGTC_441 propafenone 146 µM -0.553103197566748 0.264896940707836 no 2510 0.290096373626831 3394 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1547 harmine 94.2 µM -0.553214005932011 0.264856038204548 no 2511 0.290058438727415 3482 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_584 0986-0246 15.4 µM -0.553535432863391 0.264737408593784 no 2512 0.289948412373567 3499 53315 YDR232W HEM1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.554196101219435 0.264493659414807 no 2513 0.289722323132449 3431 16623 A steroid. SGTC_205 1486-1330 71.903 µM -0.555493786897482 0.264015219631537 no 2514 0.289278479344525 3432 4118834 SGTC_575 k072-0246 11.9 µM -0.559178432093791 0.262659147121561 no 2515 0.288019975557023 3446 6796779 SGTC_105 0111-0055 734.78 µM -0.559496698147122 0.262542182013381 no 2516 0.287911392010935 3427 5179370 SGTC_2544 sphondin 68.51 µM -0.559577585557502 0.262512459546278 no 2517 0.287883798551918 3496 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_570 0987-0065 62.6 µM -0.559761966469838 0.262444714333768 no 2518 0.287820904592135 3358 3104428 SGTC_969 1313-0238 134 µM -0.560669933825869 0.262111239693448 no 2519 0.28751128360904 3382 5212874 SGTC_2316 5844804 197.44 µM -0.561158613609894 0.261931849257931 no 2520 0.287344706805543 3440 776813 SGTC_890 0929-0006 47.2 µM -0.561213502292424 0.261911703995467 no 2521 0.287325999693941 3369 1378169 SGTC_2876 9059903 25.97 µM -0.56194447583856 0.261643497607109 no 2522 0.287076924896777 3449 6916095 SGTC_997 3996-0078 137 µM -0.562688810114843 0.261370533855521 no 2523 0.286823402624682 3397 735687 SGTC_231 b-estradiol 524 µM -0.563835914145417 0.260950152154311 no 2524 0.286432903785725 3356 450 A steroid. SGTC_1194 1488-0194 225 µM -0.564672864734265 0.26064365259719 no 2525 0.28614814713056 3416 1391452 SGTC_174 3553-0389 74.3 µM -0.565109425833612 0.260483853183567 no 2526 0.285999668833553 3481 738071 SGTC_2680 butyl paraben 22.24 µM -0.566982541766891 0.259798788373496 no 2527 0.285363021454526 3476 7184 An antifungal and steroid mimetic. SGTC_679 0422-0091 41.4 µM -0.5671248133041 0.259746792648841 no 2528 0.285314692831465 3431 627384 YHR062C RPP1 SGTC_2113 5491891 107.031 µM -0.568773132541948 0.259144776138216 no 2529 0.284755055038505 3434 789979 SGTC_2092 5303694 80.6725 µM -0.569587494825228 0.258847612617144 no 2530 0.28447875602382 3419 1963699 SGTC_3245 9134821 49.47 µM -0.569819534940534 0.258762972691228 no 2531 0.284400052283125 3395 17014901 SGTC_1886 st057356 49.9 µM -0.570026681896243 0.258687425001702 no 2532 0.284329800635394 3353 24207747 SGTC_1277 0873-0036 22 µM -0.570305921481336 0.258585602787456 no 2533 0.28423511268048 3479 5965735 SGTC_2885 9057732 51.95 µM -0.570387032358149 0.258556030322626 no 2534 0.28420761144355 3507 6471414 SGTC_2835 9006588 71.43 µM -0.571222559767461 0.258251504780476 no 2535 0.283924393833304 3517 2345538 SGTC_484 loperamide 105 µM -0.571592795993753 0.258116623863454 no 2536 0.28379893855497 3415 3955 An opioid-receptor agonist. SGTC_1724 st037281 8.293 µM -0.572526286638017 0.257776705717974 no 2537 0.283482741274624 3442 574124 YDL195W SEC31 SGTC_1322 1348-1070 12 µM -0.573148834877661 0.257550142306396 no 2538 0.283271962074812 3478 6758089 SGTC_2594 a-mangostin 100 µM -0.57421165955697 0.257163588628946 no 2539 0.28291229012811 3493 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3046 9092212 49.47 µM -0.575190601613528 0.256807810479974 no 2540 0.282581199148748 3479 25236637 SGTC_1761 st044296 37 µM -0.576403111493079 0.256367501913323 no 2541 0.282171370891697 3456 1826700 SGTC_96 0929-0093 37.281 µM -0.576928399630307 0.256176871977815 no 2542 0.281993912404404 3402 6991579 SGTC_9 0092-0002 10.449 µM -0.57746277251767 0.255983021005396 no 2543 0.281813439983598 3487 759368 SGTC_1673 st016611 27.3 µM -0.578985162869193 0.255431173253437 no 2544 0.281299592291642 3513 5226799 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.583073920403455 0.25395213166501 no 2545 0.279921769613388 3379 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1245 0418-0076 17.2 µM -0.585801373405979 0.252968024509869 no 2546 0.279004500346807 3492 6790114 SGTC_1113 artemisinin 1.17947 µM -0.586333444163663 0.252776279363647 no 2547 0.278825730279685 3489 2240 An anti-malaria and mitochondrial poison. SGTC_1491 4138-0063 26.5 µM -0.586671144507217 0.252654620218123 no 2548 0.278712295511985 3486 23883227 SGTC_2607 solasodine 47.35 µM -0.586689741778537 0.252647921304184 no 2549 0.278706049273987 3450 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_175 3793-3120 23.7 µM -0.587103617810397 0.252498863433434 no 2550 0.27856705898118 3428 5322297 SGTC_670 4204-0025 119 µM -0.58909587254451 0.251781999771505 no 2551 0.27789848101919 3478 719039 SGTC_2889 9059656 51.95 µM -0.590453225608898 0.251294205970053 no 2552 0.27744341786331 3501 3949838 SGTC_2438 5259590 200 µM -0.590495804036781 0.251278912589686 no 2553 0.277429149009199 3464 1201127 SGTC_41 0478-0632 82.643 µM -0.590971129900147 0.251108217786073 no 2554 0.277269882486365 3537 3750424 SGTC_1087 pterostilbene 9.05 µM -0.591166824236655 0.251037959602859 no 2555 0.277204324559446 3537 5281727 Similar to reservatol, lowers cholesterol. SGTC_1267 0828-0272 9.49 µM -0.591636850305545 0.25086925333742 no 2556 0.277046896033281 3566 745334 SGTC_2675 theaflavin digallate 100 µM -0.59267506118304 0.250496821522471 no 2557 0.276699317268601 3505 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2638 epoxomicin 18 µM -0.59342473770189 0.250228076359149 no 2558 0.276448468770094 3484 9915668 A protesome inhibitor. SGTC_1953 st076800 12.1 µM -0.594699656603242 0.24977139285843 no 2559 0.276022125711218 3441 297591 SGTC_2751 anetholtrithion 17.25 µM -0.596468760401887 0.249138423251553 no 2560 0.275431058652894 3485 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_18 0111-0177 500 nM -0.597973563622302 0.248600690318113 no 2561 0.27492878642166 3572 721752 SGTC_713 1488-1073 324 µM -0.599287708797484 0.248131594169019 no 2562 0.274490521409651 3499 3312542 SGTC_1763 st044482 94.5 µM -0.59968191375139 0.247990971213864 no 2563 0.274359122027394 3489 88505 SGTC_62 0180-0423 3.232 µM -0.600074613814602 0.247850927384582 no 2564 0.274228255147888 3487 30102 YGL099W LSG1 SGTC_2258 7960471 200 µM -0.600814822931111 0.247587070467698 no 2565 0.27398166509363 3464 2974708 SGTC_1133 3473-0247 50 µM -0.601121984024311 0.247477623073683 no 2566 0.273879370963042 3427 711311 SGTC_1506 4226-2149 212 µM -0.60190675380998 0.247198111979798 no 2567 0.27361810416746 3498 991114 SGTC_402 epigallocatechin gallate 10 µM -0.602299007600678 0.247058466432978 no 2568 0.27348756065777 3445 65064 An antioxidant. SGTC_2698 st077697 67.5 µM -0.603180711764451 0.246744726673153 no 2569 0.273194238839697 3445 3154499 SGTC_1048 3161-0300 24.5 µM -0.603970175104429 0.246463990395361 no 2570 0.272931735661214 3535 2165101 SGTC_3338 9144300 39.5675 µM -0.604287103492218 0.246351337575799 no 2571 0.272826389510653 3469 4901274 SGTC_1408 3909-7976 48.8 µM -0.60657143120381 0.245540185811236 no 2572 0.27206768220452 3515 24152374 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.609093683369413 0.244646217809239 no 2573 0.271231172109352 3604 688751 SGTC_3211 9128781 49.47 µM -0.609310231661784 0.244569547852789 no 2574 0.271159413234733 3459 17194361 SGTC_323 4013-0906 34.3 µM -0.609608719938234 0.244463887871426 no 2575 0.271060516947696 3532 2910086 SGTC_1783 st039459 87.517 µM -0.610437969199287 0.244170476276812 no 2576 0.270785861335088 3587 729761 SGTC_3051 9093778 49.47 µM -0.611078151599601 0.243944091774949 no 2577 0.270573921616458 3517 17217378 SGTC_3343 9148379 18.9835 µM -0.613416702356284 0.243118085046032 no 2578 0.269800422482666 3573 1955036 SGTC_2903 5923464 63.88 µM -0.613542418960416 0.243073723174274 no 2579 0.269758871836159 3566 2876576 SGTC_1345 1488-0192 31.4 µM -0.614774561032617 0.242639166516127 no 2580 0.269351805745256 3571 658348 SGTC_2273 7815444 169.05 µM -0.615120884573199 0.242517099557202 no 2581 0.269237445382521 3538 2824616 SGTC_2655 perillic acid 100 µM -0.616506130314852 0.242029181544753 no 2582 0.268780263587431 3493 5702197 An apoptosis inducer. SGTC_387 norethindrone acetate 66.7 µM -0.616515709530996 0.242025809360976 no 2583 0.268777103453606 3512 541197 SGTC_860 0443-0016 25.1 µM -0.617763156595385 0.241586886762273 no 2584 0.268365736651061 3550 5337942 SGTC_2686 alizarin 95.37 µM -0.619056838642529 0.241132152994121 no 2585 0.267939457808202 3485 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_649 1123-0311 367 µM -0.619515408796869 0.240971075753709 no 2586 0.267788437080304 3540 693629 YIL048W NEO1 SGTC_1380 2291-0730 164 µM -0.619753948671109 0.240887309439567 no 2587 0.267709895797532 3505 2999191 SGTC_3006 9075424 71.4286 µM -0.621849427913973 0.240152136441921 no 2588 0.26702044071647 3494 7465181 SGTC_377 3970-0964 33.1 µM -0.623128633753553 0.239703944738897 no 2589 0.266599997322304 3553 16481235 SGTC_1137 ixabepilone 100 µM -0.623365155308281 0.239621125386123 no 2590 0.26652229520833 3575 154225 A novel microtubule stabilizer. SGTC_315 k915-0449 187 µM -0.623730700263524 0.239493158492425 no 2591 0.266402228832419 3548 20970215 YNL149C PGA2 SGTC_805 3852-0218 479 µM -0.62389105555288 0.239437034442588 no 2592 0.266349567399084 3514 6615355 SGTC_1757 st041620 31.8375 µM -0.624479491183751 0.239231144628401 no 2593 0.266156367505173 3548 5289815 SGTC_3128 9127691 49.47 µM -0.628031344270654 0.237990430845312 no 2594 0.264991703442993 3536 41316314 SGTC_994 3910-0338 138 µM -0.628367781208044 0.237873091706519 no 2595 0.264881519096235 3617 3479481 SGTC_824 1304-0008 100 µM -0.629500628423666 0.237478221842679 no 2596 0.264510678718991 3558 768245 SGTC_902 1120-0002 2.07 µM -0.629967867240915 0.237315464034267 no 2597 0.264357803907213 3575 3280475 SGTC_3267 9137951 49.47 µM -0.631257006567609 0.236866723516987 no 2598 0.263936246701173 3535 16643986 SGTC_661 1304-0007 33.6 µM -0.631992151030282 0.236611033820408 no 2599 0.263696003036748 3551 3117130 SGTC_1073 triclabendazole 3.09 µM -0.632811790701039 0.236326135076815 no 2600 0.263428278088389 3590 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2969 9091408 28.7 µM -0.633302027884343 0.236155823729698 no 2601 0.263268214645109 3467 4286311 SGTC_371 0195-0006 7.36 µM -0.633452161640254 0.236103679885484 no 2602 0.26321920560383 3490 3928593 SGTC_227 fluconazole 33.516 µM -0.633663173998347 0.236030402656883 no 2603 0.263150331482676 3539 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1241 0364-0022 50.8 µM -0.633956352585402 0.235928612768287 no 2604 0.263054653711812 3539 4563895 SGTC_975 1335-0046 28.5 µM -0.634831682193601 0.235624847458636 no 2605 0.262769098877847 3524 16486740 SGTC_2556 citropten 84.59 µM -0.634849874307237 0.235618536545416 no 2606 0.262763165828863 3515 2775 A potential DNA crosslinker. SGTC_2128 5255449 168.493 µM -0.635634523432865 0.235346427542134 no 2607 0.262507331068174 3566 736008 SGTC_2809 7964133 12.99 µM -0.635689471611122 0.235327378527406 no 2608 0.262489419999082 3553 1253665 SGTC_2611 pyromycin 23.93 µM -0.636254751431639 0.235131461061868 no 2609 0.262305196062979 3540 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1049 3226-0134 66 µM -0.636730515351984 0.23496663829899 no 2610 0.262150196578567 3600 5702385 SGTC_254 nsc-64875 3.808 µM -0.638575799253209 0.234327965972081 no 2611 0.261549464508212 3593 56993 SGTC_1959 st077091 55.8 µM -0.638584622468675 0.234324914473433 no 2612 0.261546593809388 3583 821356 YKL052C ASK1 SGTC_3121 9125696 49.47 µM -0.638952828435539 0.234197590486341 no 2613 0.261426809680683 3613 1235365 SGTC_2467 5474540 200 µM -0.640118073055653 0.233794906597687 no 2614 0.261047920048284 3573 5413519 SGTC_2874 9043904 71.43 µM -0.640468341159305 0.23367393640547 no 2615 0.260934082474627 3499 4463428 SGTC_1407 3909-7909 12.3 µM -0.640556060136192 0.233643646813178 no 2616 0.260905577694781 3599 4411780 SGTC_1112 tnp00069 1.16933 µM -0.640710992422581 0.233590153607495 no 2617 0.260855235480857 3588 145826 SGTC_2520 obtusaquinone 4.71 µM -0.642079842497539 0.233117828268366 no 2618 0.260410671632677 3649 5967872 SGTC_3147 9097027 49.47 µM -0.642662024588156 0.232917105626426 no 2619 0.260221713679633 3582 25236841 SGTC_3082 9117008 49.47 µM -0.642938057947952 0.232821969400688 no 2620 0.260132146653025 3540 41448529 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.645755304405369 0.231852227518431 no 2621 0.259218918992383 3553 2724278 An inhibitor of dopamine biosynthesis. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.647109015070592 0.231387059827888 no 2622 0.258780695561927 3614 279621 SGTC_3014 9081533 49.47 µM -0.648171920440123 0.231022184918963 no 2623 0.25843688056811 3591 21367265 SGTC_3171 9103192 49.47 µM -0.649157687581559 0.230684077320273 no 2624 0.258118228888999 3636 13018434 SGTC_3172 9105863 49.47 µM -0.649542734260932 0.230552085540702 no 2625 0.257993816945184 3565 2348785 SGTC_3271 9137798 49.47 µM -0.650095673469862 0.230362615015897 no 2626 0.25781521188037 3539 6498326 SGTC_2333 9017922 200 µM -0.650933703421964 0.230075621139963 no 2627 0.257544641943322 3608 3163164 SGTC_3045 9092950 49.47 µM -0.65135620290972 0.229931006777874 no 2628 0.257408287891951 3625 44120432 SGTC_867 0518-0118 155 µM -0.651455346492634 0.229897078993913 no 2629 0.257376296532256 3632 6848158 SGTC_3009 9080819 71.4286 µM -0.651882761629387 0.229750845957797 no 2630 0.257238403129544 3592 17027216 SGTC_1990 st072050 59.8 µM -0.652246515037784 0.229626434771383 no 2631 0.257121078640579 3602 17233948 SGTC_2447 5741742 33.78 µM -0.652775362417312 0.229445625369729 no 2632 0.256950554635298 3626 1776504 SGTC_3292 9120825 59.784 µM -0.652938650865733 0.229389814260765 no 2633 0.256897915040484 3621 24824900 SGTC_1281 0884-0031 11.8 µM -0.653183511195979 0.229306136586092 no 2634 0.256818989487179 3614 1548255 SGTC_1766 st045414 44.774 µM -0.653506890841287 0.229195652236261 no 2635 0.25671477423487 3638 253960 SGTC_77 0828-0286 12.516 µM -0.653557849926641 0.229178244521007 no 2636 0.256698353707025 3581 745345 SGTC_3023 9089636 49.47 µM -0.653884307430361 0.229066743642124 no 2637 0.256593172397008 3679 17249241 SGTC_2020 4017018 200 µM -0.654345209349194 0.228909375377541 no 2638 0.256444712678426 3610 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1849 st056239 19.2 µM -0.657907727282886 0.227695054309036 no 2639 0.255298712499956 3527 5393181 SGTC_2232 chlorophetanol 41.5365 µM -0.65832186956419 0.227554125285358 no 2640 0.255165664028585 3656 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_313 3474-0040 5.03 µM -0.659938611239322 0.227004432535171 no 2641 0.254646612501626 3587 1043375 YIL048W NEO1 SGTC_2892 9047358 58.44 µM -0.660130620153207 0.226939199216506 no 2642 0.254585005198767 3588 6466771 SGTC_2142 5622915 118.518 µM -0.661818919740169 0.226366069849206 no 2643 0.254043639663562 3599 5322196 SGTC_928 2764-0428 58.7 µM -0.661898561522721 0.226339053951106 no 2644 0.254018116872199 3609 662578 SGTC_1746 st038117 42 µM -0.663298116428643 0.22586459753303 no 2645 0.253569821341209 3618 2898218 SGTC_2842 9000675 19.48 µM -0.663440292397529 0.225816430627525 no 2646 0.25352430380679 3576 2989072 SGTC_2714 st079313 56.9 µM -0.663501789525023 0.225795598201117 no 2647 0.253504616875646 3625 2939799 SGTC_726 3448-4391 34.2 µM -0.664689557923013 0.225393449662773 no 2648 0.253124536999225 3698 1356692 SGTC_3356 9151811 4.48 µM -0.665670438074893 0.225061654224877 no 2649 0.252810886435346 3597 1859254 YPR165W RHO1 SGTC_1473 k844-0725 134 µM -0.6659833116329 0.224955878932365 no 2650 0.252710883664728 3689 54682906 SGTC_2521 angolensin 13.4 µM -0.667513916505346 0.224438823206504 no 2651 0.252221961730453 3635 821428 A flavenoid. SGTC_353 1988-1175 58.3 µM -0.667619836832457 0.224403067085038 no 2652 0.252188146007191 3498 2788357 SGTC_2904 7225135 42.03 µM -0.668139791758679 0.224227589869614 no 2653 0.252022181846622 3693 4446116 SGTC_3275 9138069 49.47 µM -0.668149272801002 0.224224390879386 no 2654 0.252019156132404 3636 17617007 SGTC_1943 st076331 65.2 µM -0.668667442087365 0.224049595247966 no 2655 0.251853820326836 3680 24208415 SGTC_923 1900-2434 73.3 µM -0.671012604405234 0.223259463101069 no 2656 0.251106249980776 3620 5910570 SGTC_2492 derrusnin 100 µM -0.671153654066389 0.223211991263003 no 2657 0.251061324855631 3570 1715307 Part of coumarin class of compounds. SGTC_771 0250-0039 27.3 µM -0.672212876152974 0.222855681888616 no 2658 0.250724092466758 3618 3005115 SGTC_1647 st011722 22.4 µM -0.673986900282976 0.222259648308776 no 2659 0.250159821016711 3633 2854783 SGTC_2576 guaiol 23.12 µM -0.676938901143784 0.221269858971064 no 2660 0.249222360462394 3639 227829 SGTC_414 piperonyl butoxide 100 µM -0.677670249317286 0.221025032273723 no 2661 0.248990396887444 3621 5794 A potent inhibitor of cytochrome P450. SGTC_2202 7226349 200 µM -0.678845529260842 0.220631919561794 no 2662 0.248617871123058 3599 844334 SGTC_2351 9026858 72.31 µM -0.680447117382518 0.220096858810767 no 2663 0.248110697782941 3596 1409300 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.680549952901722 0.220062528828496 no 2664 0.24807815182603 3655 91467 include heat shock SGTC_3130 9127414 49.47 µM -0.681132187814216 0.219868217017241 no 2665 0.247893925842813 3654 1494646 SGTC_2289 7946404 165.07 µM -0.681143544447687 0.219864427897486 no 2666 0.247890333196411 3690 1246120 YPR165W RHO1 SGTC_3284 9108171 64.8615 µM -0.681758499715185 0.219659305177378 no 2667 0.247695834931939 3605 8687505 SGTC_1562 morin hydrate 59.1 µM -0.681773981143566 0.219654142654844 no 2668 0.247690939512302 3672 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.682900456164227 0.21927868909384 no 2669 0.247334872843977 3684 1377 SGTC_2287 7945887 168.79 µM -0.683083596024303 0.219217683547499 no 2670 0.247277010168683 3668 1245853 SGTC_309 k408-0051 1.48 µM -0.684591211723675 0.218715853975633 no 2671 0.246800957120524 3638 3640463 SGTC_2869 9037858 32.47 µM -0.685235927713285 0.218501453829106 no 2672 0.246597527916568 3623 27187042 SGTC_2872 9044037 25.97 µM -0.686574668190874 0.218056642783694 no 2673 0.24617539809651 3642 6465195 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.687397717509244 0.217783435026055 no 2674 0.245916067790669 3606 641818 YHR062C RPP1 SGTC_54 0159-0055 9 µM -0.68757560094014 0.217724413329876 no 2675 0.245860038703706 3695 3319099 SGTC_1420 4'-methoxyflavone 42 µM -0.689018742128754 0.217245920540082 no 2676 0.24540573663755 3646 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_881 0833-0569 170 µM -0.689339846476213 0.217139536759634 no 2677 0.245304714108188 3646 5418700 SGTC_2416 tofa 880 nM -0.690071737300109 0.216897169488416 no 2678 0.245074537754434 3636 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2812 7970281 58.44 µM -0.691684458587485 0.216363665552 no 2679 0.244567754498661 3680 2233435 SGTC_2704 st078022 71.1 µM -0.69392011763861 0.215625345475459 no 2680 0.243866153268565 3677 54697681 SGTC_2373 9071805 200 µM -0.69439573986268 0.215468461246648 no 2681 0.243717032315959 3673 10149009 SGTC_976 1348-1067 47.6 µM -0.694783694219665 0.215340543351161 no 2682 0.243595434170032 3712 5310671 YGL099W LSG1 SGTC_1146 3579-1023 7 µM -0.695901050833897 0.214972370268565 no 2683 0.243245399592954 3717 X1146 SGTC_1613 st002381 52.1 µM -0.696293288969035 0.214843213110285 no 2684 0.243122587563399 3669 551167 SGTC_1608 st001473 40.5 µM -0.69669565840465 0.214710766744166 no 2685 0.242996638212638 3637 7292267 SGTC_2803 7707263 71.43 µM -0.698476385003005 0.214125181897633 no 2686 0.242439660608311 3669 2199229 SGTC_2841 9004761 38.96 µM -0.698491328856203 0.214120271606654 no 2687 0.24243498938179 3600 2991039 SGTC_361 000s-0510 1.45 µM -0.70103518241939 0.213285360839284 no 2688 0.241640529584532 3681 660 SGTC_286 k060-0067 22.9 µM -0.701466668763709 0.213143932495346 no 2689 0.24150591430948 3653 5985051 SGTC_712 r015-0009 80.6 µM -0.702257782103007 0.212884771288434 no 2690 0.241259208294398 3668 6813872 YLR060W FRS1 SGTC_1798 st045719 60.953 µM -0.703448649093847 0.212495001571289 no 2691 0.240888098856442 3616 3980186 SGTC_100 0086-0128 49.5915 µM -0.70379559284442 0.212381525653683 no 2692 0.240780039347466 3659 93297 SGTC_768 0384-0033 77.3 µM -0.704925971368976 0.212012055117511 no 2693 0.240428153362289 3674 3965305 YMR134W ERG29 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.7058896729035 0.211697360941049 no 2694 0.240128375127249 3821 16725076 SGTC_3067 9117431 49.47 µM -0.707613854730121 0.211135016556579 no 2695 0.23959254333547 3706 17150885 SGTC_853 0419-0306 21 µM -0.712580343106056 0.209520089865231 no 2696 0.238052739484973 3699 762713 SGTC_2587 piperic acid 92.2 µM -0.712613292336491 0.209509400259626 no 2697 0.238042542090339 3684 5370536 SGTC_1055 3448-0672 86 µM -0.713037738160715 0.209371727448089 no 2698 0.237911202569757 3682 748378 SGTC_2734 clemastine 41.6 µM -0.714518799894349 0.208891748958398 no 2699 0.237453217671449 3686 26987 Clemastine is a selective histamine H1 antagonist. SGTC_189 3970-0742 2.116 µM -0.715344926796107 0.20862430185346 no 2700 0.237197967005999 3703 2891807 SGTC_3180 9109287 49.47 µM -0.716838530177293 0.208141281205678 no 2701 0.236736867164387 3696 18891271 SGTC_1554 st069299 38.7 µM -0.717295635076522 0.20799358875413 no 2702 0.236595849978959 3678 24207999 SGTC_2154 5570129 200 µM -0.717538364281159 0.207915187117121 no 2703 0.236520986638245 3716 673366 SGTC_1292 0kpi-0043 232 µM -0.718256841141199 0.207683221077517 no 2704 0.23629946805761 3718 3333905 SGTC_2460 5552655 174.22 µM -0.71902717170229 0.207434683576113 no 2705 0.236062089059741 3680 5401989 SGTC_2931 9014674 55.67 µM -0.7201204699259 0.207082246607021 no 2706 0.235725412569182 3712 2996810 SGTC_864 0469-0573 172 µM -0.720300758567697 0.20702416258149 no 2707 0.235669918900647 3704 689425 SGTC_2276 7947513 42.08 µM -0.721575245574009 0.206613833045787 no 2708 0.235277831544799 3598 2105100 SGTC_2022 5136654 200 µM -0.723782102000785 0.205904461192927 no 2709 0.234599759537572 3724 1713771 SGTC_1841 st054148 70 µM -0.72444553221914 0.205691490987615 no 2710 0.234396127480359 3716 675442 SGTC_3218 9131285 49.47 µM -0.724734359849601 0.205598814217037 no 2711 0.234307505824903 3713 17156417 SGTC_3035 9091303 49.47 µM -0.725496883840862 0.205354260568199 no 2712 0.234073627945855 3752 25237002 SGTC_3351 9150312 21.596 µM -0.725501915547588 0.205352647393351 no 2713 0.23407208507324 3683 4904905 SGTC_2455 5377712 9.75 µM -0.727421851094849 0.204737661901455 no 2714 0.23348378634764 3693 2243908 SGTC_1821 st053465 65.6 µM -0.72813058780264 0.204510919533427 no 2715 0.233266825601333 3693 675086 SGTC_1632 st005650 90 µM -0.728936903252852 0.204253141120621 no 2716 0.233020129853237 3745 2759605 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.729570495224507 0.204050718082966 no 2717 0.232826381309994 3719 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2781 5567276 71.43 µM -0.729803189896191 0.203976405676408 no 2718 0.232755247183968 3751 2853274 SGTC_767 0929-0023 86 µM -0.730655596063869 0.203704322536369 no 2719 0.232494772127174 3792 1204563 SGTC_2277 7947813 106.88 µM -0.730795506708732 0.203659684546258 no 2720 0.232452034252639 3779 1246798 SGTC_2044 5102272 200 µM -0.731524789651208 0.203427103887597 no 2721 0.232229334234401 3716 592666 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.732255359565661 0.203194271744462 no 2722 0.232006360306341 3766 5357218 A potent inhibitor of glutathione S-transferases. SGTC_811 0416-0114 265 µM -0.732630175151541 0.203074880032667 no 2723 0.231892010823898 3749 6612453 SGTC_1929 genistein trimethyl ether 50.5 µM -0.73270014277404 0.20305259756802 no 2724 0.231870668440033 3716 136420 SGTC_1762 st045503 25.4615 µM -0.733150975220853 0.202909056770637 no 2725 0.231733176227276 3797 4645554 SGTC_666 0272-0154 136 µM -0.734216210149744 0.202570136897124 no 2726 0.231408487720448 3772 6870312 SGTC_2343 7990716 14.84 µM -0.735755039338193 0.202081134112291 no 2727 0.23093989376531 3713 6456862 SGTC_1118 chelidonine 707.474 nM -0.735882956231951 0.202040517035663 no 2728 0.230900965233269 3727 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2253 7938677 135.83 µM -0.736266373058186 0.201918801087476 no 2729 0.230784303191323 3760 2301972 SGTC_2388 9080168 200 µM -0.736278517154988 0.2019149466525 no 2730 0.230780608651146 3704 15943073 SGTC_1181 1222-0449 220 µM -0.738307716863922 0.201271514352266 no 2731 0.230163739097905 3768 658318 SGTC_2177 5811945 192 µM -0.738608339031989 0.201176295706422 no 2732 0.230072429532028 3763 5343475 SGTC_2147 5545932 89.7195 µM -0.738683614567579 0.201152457267756 no 2733 0.230049568867747 3749 797404 SGTC_275 trichlorophene 5.69 µM -0.739430762683002 0.200915940454639 no 2734 0.229822734036261 3795 62616 SGTC_202 3594-0513 34.79 µM -0.74021363509141 0.200668293880404 no 2735 0.229585187690914 3720 708429 SGTC_3038 9091290 49.47 µM -0.741135670463471 0.200376860915974 no 2736 0.229305591729113 3748 25236843 SGTC_2403 6032726 181.2 µM -0.741166689698304 0.200367060912841 no 2737 0.229296188845388 3771 2881040 SGTC_3285 9112818 20.8695 µM -0.742132034750991 0.200062220388444 no 2738 0.229003671148783 3763 17017947 YPR165W RHO1 SGTC_148 3253-0744 288.01 µM -0.742154651186315 0.200055081824124 no 2739 0.228996820454757 3702 6893655 SGTC_93 0109-0045 59.227 µM -0.74223977338643 0.200028215554317 no 2740 0.228971037309646 3822 88733 SGTC_2824 7998404 51.95 µM -0.742701423591544 0.19988254729737 no 2741 0.228831233841064 3732 837851 SGTC_2320 7373003 200 µM -0.745806793932245 0.19890434341856 no 2742 0.227892067643297 3786 5415828 SGTC_170 4197-0004 226 µM -0.745990917136959 0.198846434638465 no 2743 0.227836450914191 3765 218692 SGTC_2792 7535235 81.82 µM -0.748835608082925 0.197953039970925 no 2744 0.226978147440854 3758 1281891 SGTC_1284 0929-0043 16 µM -0.748916306626944 0.197927731455416 no 2745 0.226953825608442 3745 1239883 SGTC_2868 9035608 32.47 µM -0.748967812864128 0.197911579194508 no 2746 0.226938302849388 3732 6462614 SGTC_1127 asiatic acid 681.4 nM -0.750837617415828 0.197325751195866 no 2747 0.22637519366162 3739 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1480 1070-0044 41.2 µM -0.751801480310375 0.197024173680529 no 2748 0.226085225834284 3763 3124987 SGTC_2244 6635614 200 µM -0.752230972343835 0.196889882286186 no 2749 0.225956085399498 3683 836499 SGTC_1034 k072-0165 12.7 µM -0.755057763387188 0.196007399025344 no 2750 0.225107162094378 3750 5835461 SGTC_1026 k007-1105 30.6 µM -0.755413448124227 0.195896529598885 no 2751 0.225000473333082 3757 7066794 SGTC_1745 st081495 74 µM -0.755703630355335 0.195806105954766 no 2752 0.22491345348592 3686 13842402 YBL026W LSM2 SGTC_343 4130-2827 29.8 µM -0.755821769052729 0.19576930002871 no 2753 0.224878031518606 3832 1118244 SGTC_3229 9132204 49.47 µM -0.756588430451715 0.195530549931847 no 2754 0.22464823743432 3768 17682924 SGTC_783 0848-0141 92.7 µM -0.757091499955575 0.195373982507824 no 2755 0.224497523067495 3749 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_541 4513-1321 94 µM -0.757477031721721 0.195254047238911 no 2756 0.22438206062238 3772 747515 SGTC_1573 oleylamine 1.06 µM -0.759909931149671 0.194498227773573 no 2757 0.223654212452905 3788 5356789 An amine of the fatty acid oleic acid. SGTC_1512 0259-0544 12.2 µM -0.760639750872385 0.194271845179924 no 2758 0.223436135043461 3746 18476 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.761266657360489 0.194077513385427 no 2759 0.223248905764185 3799 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_181 1447-1644 8.07 µM -0.761745449997642 0.19392917449961 no 2760 0.223105971715803 3740 534600 SGTC_1820 st053765 18.6 µM -0.762819260086863 0.193596739458314 no 2761 0.222785596555188 3772 3690829 SGTC_1360 1598-0022 39.8 µM -0.763521798073053 0.193379432719971 no 2762 0.222576133724893 3847 761525 SGTC_3332 9141069 11.198 µM -0.763532903846247 0.193375998714127 no 2763 0.22257282342251 3722 17332883 SGTC_2283 7944793 200 µM -0.763626309468858 0.19334711832054 no 2764 0.222544983081022 3807 2970533 SGTC_3131 9127911 49.47 µM -0.763752708425039 0.193308040799827 no 2765 0.222507311957106 3793 45595681 SGTC_2066 5222451 176 µM -0.765532552838157 0.192758295720141 no 2766 0.221977244928938 3777 2281147 SGTC_1776 st049249 45.9 µM -0.765985464281615 0.192618556418502 no 2767 0.221842475598851 3828 1822314 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.768354742503047 0.191888559340659 no 2768 0.221138230092051 3733 5355888 SGTC_1750 st081859 2.357 µM -0.76837227222451 0.191883164586548 no 2769 0.221133024319912 3768 5291695 SGTC_109 0132-0036 33.701 µM -0.768450366214208 0.191859132368084 no 2770 0.221109833730065 3619 67274 A color developer. SGTC_2051 5263410 176 µM -0.76910020047732 0.191659227383686 no 2771 0.22091691459882 3833 227584 SGTC_281 1672-3440 14.9 µM -0.769483487113474 0.191541378831077 no 2772 0.220803171816877 3832 6833000 SGTC_933 2914-0560 114 µM -0.772725320975915 0.190546393683398 no 2773 0.219842478965918 3809 463887 SGTC_1114 scopoletin 1.73284 µM -0.772993359387515 0.190464269481737 no 2774 0.219763155342562 3786 5280460 A coumarin with genotoxic properties. SGTC_117 lucigenin 22.078 µM -0.774266694671149 0.190074429652351 no 2775 0.219386547411784 3809 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_557 1315-0110 16.2 µM -0.774492881821039 0.190005232319764 no 2776 0.219319687992783 3805 6833801 SGTC_681 1642-0006 26.6 µM -0.778879462689556 0.188666311349224 no 2777 0.218025361442109 3820 4446530 SGTC_163 TUB2.036 7.546 µM -0.779640277774763 0.188434680183998 no 2778 0.217801320497459 3843 15992207 YJR013W GPI14 SGTC_2756 carbadox 75.1 µM -0.779909430642068 0.188352778253018 no 2779 0.217722093544813 3820 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1020 4335-0961 93.3 µM -0.78019457243554 0.188266034926978 no 2780 0.217638178284789 3752 669075 SGTC_1273 0849-0096 14.1 µM -0.780375988548766 0.188210858945574 no 2781 0.217584798491711 3818 5286025 SGTC_1158 4092-0494 91.8 µM -0.783168271176221 0.187362871956507 no 2782 0.216764152196001 3923 1148199 SGTC_3317 9138495 8.753 µM -0.786058616874833 0.186487596260845 no 2783 0.21591657357968 3772 17020139 SGTC_1027 k015-0025 8.67 µM -0.786214239277025 0.186440541500414 no 2784 0.215870992678319 3800 3598955 SGTC_2805 7950783 58.44 µM -0.788603037189462 0.185719175837277 no 2785 0.215172027623727 3847 1178958 YDL195W SEC31 SGTC_248 streptozotocin 5.23457 mM -0.789007983509912 0.185597062607008 no 2786 0.215053670217401 3811 5300 DNA alkylating agent. SGTC_1629 st005085 44.9 µM -0.78943242208731 0.185469124897683 no 2787 0.214929656212622 3807 24207091 SGTC_2224 6650123 117.647 µM -0.792036751380659 0.184685305838019 no 2788 0.214169623694296 3776 2908370 SGTC_856 0433-0016 11.3 µM -0.796150553746989 0.183451387319875 no 2789 0.212972266736394 3884 3911780 SGTC_998 3996-0085 177 µM -0.796691610056442 0.183289482907527 no 2790 0.21281507889221 3861 715391 SGTC_375 3970-0961 9.27 µM -0.796833146550859 0.183247144568519 no 2791 0.2127739708442 3792 2898222 SGTC_119 0121-0043 24.815 µM -0.798662985509539 0.182700327271702 no 2792 0.212242927487533 3890 1092378 SGTC_78 0336-0123 156.75 µM -0.799828765878042 0.182352484825865 no 2793 0.211905007059618 3690 6765896 SGTC_530 4358-1714 28 µM -0.801191743630952 0.181946328231991 no 2794 0.211510325123931 3894 1564641 SGTC_1031 k035-0009 16 µM -0.802759327741669 0.181479900635194 no 2795 0.211056927280984 3920 5180959 SGTC_2207 7258803 200 µM -0.803767524517129 0.181180312080467 no 2796 0.210765624261569 3782 3666799 SGTC_637 1181-0519 7.26 µM -0.803977402739871 0.181117985143827 no 2797 0.210705012832847 3847 6252091 YGR060W ERG25 SGTC_1624 st003710 6.25 µM -0.80442050754221 0.180986441695144 no 2798 0.210577080714175 3833 24207033 SGTC_1982 st072467 71.9 µM -0.80616984178614 0.180467705995947 no 2799 0.210072462654674 3824 3163533 SGTC_1826 st055655 41.6 µM -0.807032712029318 0.180212180138415 no 2800 0.209823818451859 3884 676168 SGTC_2377 9073351 62.6 µM -0.807469268132975 0.180082987259 no 2801 0.209698086624905 3822 7337946 YHR072W ERG7 SGTC_1023 4482-3888 16 µM -0.807919905652625 0.17994968818079 no 2802 0.209568345712346 3824 3303168 SGTC_2943 9068529 45.32 µM -0.808073293312262 0.179904330079378 no 2803 0.209524195371195 3855 3270634 SGTC_2135 5326629 150.42 µM -0.808367665647585 0.179817301664951 no 2804 0.20943948003022 3811 5020077 SGTC_59 0330-0160 1.33 µM -0.808406206200389 0.179805909470865 no 2805 0.209428390208181 3809 4293482 SGTC_2750 bromebric acid 70.15 µM -0.809509414347823 0.17948000465087 no 2806 0.209111094938136 3930 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_31 0508-1974 57.237 µM -0.811282915839357 0.178956863605837 no 2807 0.20860160935058 3796 6810525 SGTC_15 0266-0086 27.098 µM -0.813304718087043 0.178361651469712 no 2808 0.208021686324683 3923 1712902 YIL048W NEO1 SGTC_2635 hydroquinidine 100 µM -0.814133808549212 0.178117930928254 no 2809 0.207784149845417 3799 442912 An experimental heart treatment. SGTC_2512 diallyl trisulfide 49.23 µM -0.815174889550929 0.177812190839489 no 2810 0.207486104549573 3875 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_69 0096-0274 206.684 µM -0.816379084712053 0.177458961274845 no 2811 0.207141677570165 3961 6741392 SGTC_328 k915-0120 63.5 µM -0.817266078511487 0.177199060679565 no 2812 0.206888193778505 3849 6624543 SGTC_389 tpck 16.7 µM -0.817325012713134 0.177181800721926 no 2813 0.206871358155515 3874 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_127 0180-0333 59.125 µM -0.818095556932627 0.176956230481494 no 2814 0.206651312852619 3770 771601 SGTC_845 0330-0138 4.51 µM -0.818943196655647 0.176708300903135 no 2815 0.20640941146295 3791 9039800 SGTC_3013 9080133 71.4286 µM -0.819028843062675 0.176683262060631 no 2816 0.20638497882912 3917 17050193 SGTC_1323 1348-1351 11.2 µM -0.819101922729534 0.176661898895316 no 2817 0.206364132505888 3809 6989654 SGTC_2753 fluvastatin 17.09 µM -0.821926148733227 0.17583755262681 no 2818 0.205559464850413 3908 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1339 1486-1321 22.7 µM -0.822559204062602 0.175653108729272 no 2819 0.205379353048747 3885 3469382 SGTC_1476 4112-3294 3.34 µM -0.824449297972232 0.175103149955257 no 2820 0.204842156743074 3902 704369 SGTC_289 k017-0060 526 µM -0.824650108354811 0.175044784610825 no 2821 0.204785132217284 3849 5512909 SGTC_124 0136-0217 7.121 µM -0.825363413731064 0.174837562890106 no 2822 0.204582649809313 3935 3976905 SGTC_746 1095-0025 46.6 µM -0.825493295280058 0.174799847877881 no 2823 0.204545793811958 3895 6749286 SGTC_2095 5432005 200 µM -0.827455744364699 0.174230620382444 no 2824 0.203989398043299 3874 783734 SGTC_3028 9087778 49.47 µM -0.827694929780935 0.174161322944785 no 2825 0.203921645632147 3858 17217395 SGTC_261 5-fluorouridine 15.376 µM -0.827794496753665 0.174132481300091 no 2826 0.203893445932643 3870 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2851 9015922 71.43 µM -0.828357199648468 0.173969539767292 no 2827 0.203734118974977 3876 2996893 SGTC_847 0342-0274 5.54 µM -0.828768216465391 0.173850583166852 no 2828 0.203617788214767 3880 18097 SGTC_1923 st058458 19.1 µM -0.829428889780882 0.173659479348672 no 2829 0.20343087979824 3868 3534982 SGTC_1359 1582-0056 520 nM -0.829733647750766 0.173571371295035 no 2830 0.203344696461899 3961 3661189 SGTC_169 k015-0017 16.025 µM -0.830418479514683 0.173373484562975 no 2831 0.203151110524852 3858 1840002 SGTC_1424 4048-1941 275 µM -0.830426127410012 0.173371275463547 no 2832 0.203148949264916 3956 X1424 SGTC_469 w7 172 µM -0.833570239890525 0.172464614746853 no 2833 0.202261600784592 3912 45115570 A P450 inhibitor. SGTC_2691 st077356 60.2 µM -0.834120861070151 0.172306145071947 no 2834 0.202106440400142 3948 2839272 SGTC_2049 5262831 67.185 µM -0.834370856829905 0.172234226558097 no 2835 0.202036017228888 3930 763417 SGTC_589 1227-0070 34.1 µM -0.837825592499229 0.171242333722435 no 2836 0.201064331504789 3927 2841384 SGTC_605 1315-0399 119 µM -0.842152629897586 0.170005156387226 no 2837 0.199851262534185 3974 24020461 SGTC_924 2046-0044 21.3 µM -0.845291924946829 0.169111171221312 no 2838 0.198973934244558 3891 3623589 SGTC_3062 9077494 49.47 µM -0.845805639458519 0.168965167351246 no 2839 0.198830589464379 3889 16459633 SGTC_2206 7254556 146.969 µM -0.847761760157035 0.168409955649967 no 2840 0.198285331691802 3921 4398905 SGTC_2178 5812956 200 µM -0.848345657765636 0.168244453837972 no 2841 0.198122748542993 3869 5403383 SGTC_1652 st011932 78 µM -0.8484906174606 0.168203382213973 no 2842 0.198082397770616 3817 1551076 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.849846694073571 0.167819475670297 no 2843 0.197705162629841 3840 140250 A respiratory chain inhibitor. SGTC_379 3970-0972 5.9 µM -0.85106121964408 0.167476121634909 no 2844 0.197367673167886 3901 2898042 YBL034C STU1 SGTC_906 1165-0455 526 µM -0.851390630923566 0.16738307307113 no 2845 0.197276197250718 3874 3252859 SGTC_2359 9039622 200 µM -0.852996363195594 0.166929980142096 no 2846 0.196830660500785 3852 6463596 SGTC_632 0781-2353 4.65 µM -0.853553834663687 0.166772862387107 no 2847 0.19667612349462 3970 6811515 YHR007C ERG11 SGTC_3053 9095903 49.47 µM -0.854559830577791 0.166489574032717 no 2848 0.19639743679572 3990 17174018 SGTC_2055 5235184 200 µM -0.857103099047702 0.165774776166886 no 2849 0.195693954311227 3963 2836034 SGTC_3253 9135987 49.47 µM -0.858700274502399 0.165326898029915 no 2850 0.195252949496114 3883 4182430 SGTC_3185 9108267 49.47 µM -0.86071191055828 0.164763912506866 no 2851 0.194698365781719 3901 4910486 SGTC_1091 telmisartan 47.6 µM -0.863356736901509 0.164025611585347 no 2852 0.193970679159396 3984 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1193 1488-0126 41.5 µM -0.8649657271289 0.163577515037798 no 2853 0.193528800112408 3910 1384710 SGTC_1440 4100-1550 40 µM -0.8673163819596 0.162924298532506 no 2854 0.1928843415889 3922 742806 SGTC_410 α-linolenic acid 100 µM -0.868151258404156 0.162692705902498 no 2855 0.19265576662832 4005 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_604 1000-0114 314 µM -0.868297557770079 0.162652144886425 no 2856 0.192615729404011 3920 1572745 SGTC_2956 9076196 2.52 µM -0.869082360404446 0.16243467325273 no 2857 0.192401042092817 3945 16423868 SGTC_3001 9076041 71.4286 µM -0.869933020571304 0.16219916607937 no 2858 0.192168504392808 3916 16004211 SGTC_2848 9016370 25.97 µM -0.870477179321203 0.162048631165517 no 2859 0.192019842577588 3892 7894410 SGTC_2117 5521686 200 µM -0.870720915538406 0.161981234015195 no 2860 0.191953277726355 3885 803312 SGTC_1391 3442-0225 151 µM -0.871152975534385 0.161861807060881 no 2861 0.191835315985535 3886 5227075 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.871434869626227 0.161783918832802 no 2862 0.191758376719658 3958 6708784 An antioxidant flavonoid SGTC_1697 st025554 27.742 µM -0.872004609733761 0.161626572419899 no 2863 0.191602931386208 3903 1269519 SGTC_2543 pimpinellin 60.67 µM -0.873009772915516 0.161349217555267 no 2864 0.191328875449395 3780 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3047 9092122 49.47 µM -0.875266743455777 0.160727582958248 no 2865 0.190714392431092 3932 17173831 SGTC_2528 xanthyletin 44.79 µM -0.877454611632268 0.160126475998011 no 2866 0.190119880779287 3986 65188 An natural product with antifungal activity of unknown mechanism. SGTC_42 0133-0086 60.653 µM -0.878935885744683 0.159720338067739 no 2867 0.189718019930401 3838 162923 Model of phenazepam hydroxylation. SGTC_993 3909-8757 62.7 µM -0.880916299008604 0.159178399305007 no 2868 0.18918156245982 3912 4288324 YLR208W SEC13 SGTC_177 1327-0068 8.361 µM -0.883005999278452 0.158607861731518 no 2869 0.188616515063345 3936 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2665 lovastatin 100 µM -0.883057580601224 0.158593795790392 no 2870 0.188602580831421 3977 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_278 4092-0821 23.9 µM -0.88332514422802 0.158520845797946 no 2871 0.188530311101366 3962 877900 SGTC_235 0330-0087 5 mM -0.88408846087075 0.158312851992722 no 2872 0.188324230873782 3959 46494818 YHR062C RPP1 SGTC_499 genistein 192 µM -0.886956073573292 0.157533065654098 no 2873 0.187551275201724 3976 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_719 2810-4230 27.3 µM -0.890069601605135 0.156689270604399 no 2874 0.186714257157839 3944 721079 SGTC_1109 tnp00067 928.257 nM -0.89619540541943 0.155037820811134 no 2875 0.185074204583484 3961 676295 SGTC_482 fipronil 114 µM -0.897732162223467 0.154625337868882 no 2876 0.184664179254358 4030 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_290 2043-6722 48.1 µM -0.897923881702982 0.154573929117416 no 2877 0.184613065831168 3978 773758 YLR208W SEC13 SGTC_1439 4092-1168 46 µM -0.898600339667319 0.154392630088286 no 2878 0.184432788866291 3962 2886240 SGTC_14 0354-0009 295 µM -0.90017255505484 0.153971800401307 no 2879 0.184014214557154 4032 1713507 SGTC_1816 st051957 91.6 µM -0.900390930580705 0.153913408636932 no 2880 0.183956122785223 3946 674121 SGTC_471 1-acyl-paf 4 µM -0.900811737467312 0.153800929775357 no 2881 0.183844212882143 3905 16759367 SGTC_1515 3460-0031 42.1 µM -0.901161084315785 0.153707593047249 no 2882 0.183751339370886 3894 2876596 SGTC_421 streptovitacin 30 mM -0.90121508275722 0.153693169362964 no 2883 0.18373698654757 4047 91467 include heat shock SGTC_521 r062-0005 13.8 µM -0.902708048705952 0.153294733675524 no 2884 0.18334043180087 3876 2832033 SGTC_1978 st071761 42 µM -0.902714915497613 0.153292902681169 no 2885 0.18333860910902 3990 5147680 SGTC_1462 k081-0014 26.5 µM -0.907138337176858 0.152116431142681 no 2886 0.182166823494343 3623 3270634 SGTC_480 am 92016 50 µM -0.907945242853081 0.151902471526207 no 2887 0.181953576265559 3943 2129 K+ channel blocker. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.908508888143694 0.151753133649086 no 2888 0.18180470999357 3920 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2138 5575593 77.673 µM -0.908662799849294 0.15171237169096 no 2889 0.181764073096595 3947 762213 SGTC_3326 9140064 16.379 µM -0.91361823549621 0.150403863270232 no 2890 0.18045874052016 3931 1868434 SGTC_1770 st043884 66.3 µM -0.914101257291378 0.150276722259214 no 2891 0.180331820969755 3977 670149 SGTC_3029 9088683 49.47 µM -0.9146356940512 0.150136131289668 no 2892 0.180191456833786 4014 25236615 SGTC_1992 st073643 23.3 µM -0.915297814514335 0.14996207299774 no 2893 0.180017653066086 3935 3161292 SGTC_2058 5236698 133 µM -0.916284278991473 0.149703000791526 no 2894 0.179758905702515 3993 766665 SGTC_1296 1068-0102 11.9 µM -0.919253079991969 0.14892511600017 no 2895 0.178981606631492 4003 767053 SGTC_947 3447-0010 211 µM -0.92177651223885 0.148266053717759 no 2896 0.178322580664134 3949 748350 SGTC_613 3914-0030 117 µM -0.923127246770841 0.147914075983141 no 2897 0.177970448510466 3724 1145395 SGTC_1856 st057054 55.7 µM -0.923170458667035 0.14790282496215 no 2898 0.177959190550884 4035 1266018 SGTC_118 0083-0097 135.343 µM -0.925136853011328 0.147391443827229 no 2899 0.177447362712101 4028 5207356 SGTC_3120 9124077 49.47 µM -0.92567792923965 0.147250939484867 no 2900 0.177306690532396 4094 18774327 YGL155W CDC43 SGTC_2205 7238770 200 µM -0.926272905788142 0.14709654221029 no 2901 0.177152086345448 4054 279867 SGTC_883 0850-0245 24.6 µM -0.931211275967163 0.145819218183085 no 2902 0.175872143090417 4086 6823229 YPR165W RHO1 SGTC_2227 7312221 64.1025 µM -0.932304196239232 0.145537541659376 no 2903 0.175589669866859 4069 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1672 st016598 6.51 µM -0.932868981637627 0.145392123950537 no 2904 0.175443809696536 4045 4665860 YNL267W PIK1 SGTC_2079 5212404 121 µM -0.932971353567429 0.145365776279368 no 2905 0.175417379583664 3969 758462 SGTC_2390 9097792 176.6 µM -0.934423715581552 0.144992324941331 no 2906 0.17504268457013 4009 4497149 SGTC_1184 1269-1718 139 µM -0.934632559750438 0.144938677209949 no 2907 0.17498884663046 4072 5403821 SGTC_3 0833-0587 95.581 µM -0.93611954970739 0.14455708669992 no 2908 0.174605819253886 3932 5382644 SGTC_483 fpl-64176 144 µM -0.938799152974156 0.143871158645545 no 2909 0.173916936945993 4065 3423 SGTC_123 0083-0120 66.675 µM -0.939722829936785 0.143635224409576 no 2910 0.173679875763797 3980 16001701 SGTC_918 glabranin 770.725 nM -0.946468150417664 0.141920189542743 no 2911 0.171954929829162 4039 124049 Also referred to as licorice root. SGTC_3350 9150499 3.57 µM -0.946659763785659 0.141871674169472 no 2912 0.171906089839497 3993 4910996 YPR165W RHO1 SGTC_807 1315-0151 48 µM -0.948919203735963 0.141300444279496 no 2913 0.171330853348832 4066 4011080 SGTC_13 0199-0087 65 µM -0.949892905937673 0.141054755003312 no 2914 0.171083335908978 4080 4589825 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.950062563206924 0.14101197591145 no 2915 0.171040232031515 4012 66535 A nucleotide analog. SGTC_2112 5488546 200 µM -0.950955435072156 0.140786983232329 no 2916 0.170813499540821 4001 600757 SGTC_1153 4055-0057 267 µM -0.951311783061951 0.140697255984211 no 2917 0.170723063610478 4079 882706 SGTC_2337 9009472 200 µM -0.951345325067469 0.140688812216688 no 2918 0.17071455271633 3979 5742383 SGTC_2148 5546263 113.568 µM -0.953662136114241 0.140106417038755 no 2919 0.170127346104035 4019 792097 SGTC_1545 lovastatin 49.4 µM -0.954896766000929 0.139796728249088 no 2920 0.169814952687779 4106 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3318 9139014 38.6185 µM -0.955357379440619 0.139681309402346 no 2921 0.169698499802952 4028 16643984 SGTC_411 enrofloxacin 100 µM -0.955369049311422 0.139678386050202 no 2922 0.169695550076593 4129 71188 A bacterial gyrase inhibitor. SGTC_2421 5690543 90.72 µM -0.956753548108764 0.139331858431258 no 2923 0.169345831651685 4055 3397993 SGTC_3279 9140807 49.47 µM -0.9572585793521 0.139205599363352 no 2924 0.169218378168757 4076 45595718 SGTC_818 4072-2707 53.5 µM -0.957521242389076 0.139139963737681 no 2925 0.169152114899975 3951 882871 SGTC_2053 5265679 138 µM -0.95837160663821 0.138927614727186 no 2926 0.168937703719778 3964 764595 SGTC_2279 7948423 32.93 µM -0.962511214216362 0.137897043676253 no 2927 0.167896436392245 3966 1247112 SGTC_1192 1488-0095 21.4 µM -0.966138704757383 0.13699826373221 no 2928 0.166987389670598 4104 915875 SGTC_2727 riluzole 51.77 µM -0.966262657023774 0.136967623086067 no 2929 0.166956383503234 4066 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_798 1287-0182 476 µM -0.969843292319243 0.136084521538806 no 2930 0.166062304919295 4094 1649755 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.970012181896218 0.136042964324859 no 2931 0.16602021001607 4088 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2155 5570423 76 µM -0.970529289968722 0.135915777986969 no 2932 0.165891366230494 3993 797402 SGTC_2591 skatole 100 µM -0.971287339855602 0.135729477524887 no 2933 0.165702605698589 4105 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_764 1951-2361 146 µM -0.973363084379137 0.135220232253971 no 2934 0.165186439670924 4050 5438930 SGTC_2119 5528445 120.635 µM -0.973485430517096 0.135190257839915 no 2935 0.165156048920549 4078 791935 SGTC_1224 0823-0416 294 µM -0.97515999410583 0.134780452965052 no 2936 0.164740451541291 4129 3598164 SGTC_3000 9075062 71.4286 µM -0.975537120363985 0.134688279067457 no 2937 0.164646948955063 4010 17057871 SGTC_2026 5148700 152 µM -0.978113569149886 0.134059723363468 no 2938 0.16400907872135 4033 79838 SGTC_3248 9135562 49.47 µM -0.978202284560027 0.134038116122448 no 2939 0.163987143390683 4053 17650701 SGTC_3092 9117248 49.47 µM -0.980573042162802 0.13346158824518 no 2940 0.163401666796575 4155 17141857 SGTC_378 3970-0959 8.33 µM -0.980617201817475 0.133450865574917 no 2941 0.1633907741313 4099 6615653 SGTC_2575 plumbagin 510 nM -0.983714811828092 0.132700194603692 no 2942 0.162627877497286 3981 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3302 9125395 16.351 µM -0.986168017576212 0.132107755275364 no 2943 0.162025335371666 4026 17599668 SGTC_1933 st074711 15.9 µM -0.98767104944128 0.131745681434565 no 2944 0.161656888704343 4038 17250958 SGTC_1716 st033144 30.6155 µM -0.989387118396764 0.131333125743826 no 2945 0.16123688730115 4091 674617 SGTC_2683 piperine 63.03 µM -0.989552780128752 0.131293346703 no 2946 0.161196379927348 4059 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1911 st060208 74.3 µM -0.990604300754751 0.131041047393718 no 2947 0.16093941841443 4128 688783 SGTC_90 0870-0863 4.608 µM -0.991064901853979 0.130930637447261 no 2948 0.160826944959574 4087 1738164 SGTC_1975 st070967 30.8 µM -0.991988731761015 0.130709381481245 no 2949 0.160601511119588 4048 261391 SGTC_833 3852-0053 558 µM -0.992432906115363 0.130603094410059 no 2950 0.160493196786935 4146 3123681 SGTC_2785 7756463 72.73 µM -0.992732207226625 0.130531507959482 no 2951 0.160420237503195 4037 2201551 SGTC_308 4092-1169 104 µM -0.993485380060091 0.130351485129578 no 2952 0.160236735853716 4006 2268590 YDL196W YDL196W SGTC_2777 climbazole 1.536 µM -0.993892531260531 0.130254239691012 no 2953 0.160137595435332 3954 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_272 doxorubicin 8.13 µM -0.994418188331933 0.130128764139798 no 2954 0.160009658420451 4066 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3163 9099914 49.47 µM -0.997364682222641 0.129426977939442 no 2955 0.159293763913626 4089 16268368 SGTC_1148 3909-7663 27.7 µM -0.998393327759192 0.129182597257328 no 2956 0.159044333888588 4119 4084526 SGTC_1019 4262-0212 3.4 µM -0.999158852776014 0.129000935224338 no 2957 0.158858872535273 4102 4677213 SGTC_639 0833-0042 114 µM -1.00176422318042 0.128383998577068 no 2958 0.158228740135017 4086 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2468 5987765 72.9 µM -1.00244097924674 0.128224082339625 no 2959 0.158065329290597 4137 26772094 SGTC_3198 9112019 49.47 µM -1.00477777359864 0.127672965735049 no 2960 0.157501934329159 4137 45595555 SGTC_2256 7954252 200 µM -1.00506258806665 0.12760590698205 no 2961 0.157433356646184 4112 2972920 SGTC_1300 1094-0077 113 µM -1.00597657395564 0.127390877006776 no 2962 0.157213419504508 4074 5532636 SGTC_2233 sulbentine 40.3845 µM -1.0067673191653 0.127205044835843 no 2963 0.157023301487035 4083 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2929 9013348 24.6 µM -1.00755505526009 0.127020107444123 no 2964 0.156834057377348 4095 2995952 SGTC_311 1315-0136 58 µM -1.00844851714187 0.126810575312408 no 2965 0.156619595640635 4135 6759207 SGTC_1516 st013856 110 µM -1.00891889664974 0.126700360001856 no 2966 0.156506765908271 4143 5281404 A mutagen and neurotoxin. SGTC_447 ml7 120 µM -1.00940951453834 0.126585473699052 no 2967 0.156389138642085 4116 4216 Selective myosin light chain kinase inhibitor. SGTC_3191 9110352 49.47 µM -1.00944815131722 0.126576429340529 no 2968 0.15637987781997 4043 17122424 SGTC_1317 1273-0028 910 nM -1.01020401207326 0.126399582872289 no 2969 0.156198778740169 4080 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_953 1188-0045 9.7 µM -1.01257268511216 0.125846506907763 no 2970 0.155632156151051 4122 6144426 SGTC_3321 9137793 26.8275 µM -1.01407937381736 0.125495580466972 no 2971 0.155272439637192 4074 4904192 SGTC_1846 st056244 14.8 µM -1.01545787581114 0.125175109066204 no 2972 0.154943808333462 4136 5393182 SGTC_735 3076-0345 636 µM -1.01694356639276 0.124830359014173 no 2973 0.154590138254483 4168 2888990 SGTC_872 0588-0139 234 µM -1.02091896412046 0.123911144424403 no 2974 0.153646416746709 4065 2047100 SGTC_3113 9123498 49.47 µM -1.02238383954919 0.123573624867298 no 2975 0.153299633074147 4209 8897275 SGTC_3243 9134147 49.47 µM -1.02368559833308 0.123274229508016 no 2976 0.152991899930163 4180 24282180 SGTC_2623 humulene 100 µM -1.02519234669228 0.122928323073422 no 2977 0.152636219353801 4132 6187145 An anti-inflammatory. SGTC_1362 1611-0397 101 µM -1.02722040770125 0.122463813422099 no 2978 0.152158345325244 4087 27816 SGTC_3037 9091026 49.47 µM -1.02778051324021 0.122335743484072 no 2979 0.15202654236291 4055 25236398 YIL048W NEO1 SGTC_91 0417-1751 58.384 µM -1.02855985592235 0.122157700713304 no 2980 0.151843275134321 4239 6795624 SGTC_3310 9130229 44.1445 µM -1.02948175446913 0.121947325691575 no 2981 0.151626674612961 4162 7761258 SGTC_2109 5483026 200 µM -1.03080641945748 0.121645486073122 no 2982 0.151315803649129 4124 759335 SGTC_743 1275-0778 158 µM -1.03113818706865 0.121569971427339 no 2983 0.151238011207162 4113 2849257 YMR203W TOM40 SGTC_1847 st056231 15 µM -1.0314466101232 0.12149979986596 no 2984 0.151165716432352 4127 5393180 SGTC_2285 7945142 200 µM -1.0315620759132 0.121473536734734 no 2985 0.151138657013194 4174 2970608 SGTC_2954 9074818 52.69 µM -1.03182430977831 0.121413905473576 no 2986 0.15107721445253 4156 16648742 SGTC_1617 st002906 78 µM -1.03204087233813 0.121364675260445 no 2987 0.151026485414122 4114 5150859 SGTC_538 2922-0838 53.3 µM -1.03363226013107 0.121003342581851 no 2988 0.150654055999903 4135 777039 SGTC_2721 ifenprodil 61.44 µM -1.03367891124962 0.120992761640008 no 2989 0.150643147563886 4128 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3355 9151058 44.0485 µM -1.0352414542216 0.12063873721743 no 2990 0.150278081832851 4109 17015728 SGTC_2694 st077685 81.9 µM -1.03766610662657 0.12009083015132 no 2991 0.149712764784978 4075 2838096 SGTC_266 formosanin C 406 nM -1.03883683273787 0.119826905876778 no 2992 0.149440314036742 4014 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2082 5219693 150 µM -1.04098303043168 0.119344137416035 no 2993 0.14894171203268 4128 2834649 SGTC_98 0074-0023 107.663 µM -1.04164508808934 0.119195490706647 no 2994 0.148788128188873 4154 3563821 SGTC_1144 3486-0183 12.5 µM -1.04237396474484 0.119031992833457 no 2995 0.148619166150788 4122 6744069 SGTC_2405 ticlatone 3.52 µM -1.04376012538108 0.118721493455337 no 2996 0.148298192153092 3975 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_531 3788-1495 174 µM -1.04614243651512 0.118189194425122 no 2997 0.147747637484184 4106 2896655 SGTC_2580 diallyl disulphide 81.36 µM -1.04689077334288 0.118022336341721 no 2998 0.147574978899105 4130 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2794 7785382 27.27 µM -1.04737952323449 0.117913448843354 no 2999 0.147462286007226 4109 2205081 SGTC_2100 5377183 190 µM -1.04855170600243 0.117652590549546 no 3000 0.147192246462283 4154 2844202 SGTC_1908 st060353 56.5 µM -1.04868250813776 0.11762350711341 no 3001 0.147162133723056 4204 4227716 SGTC_2378 9074213 121.43 µM -1.0507721582223 0.117159570045535 no 3002 0.146681622946669 4111 657714 SGTC_3074 9116018 49.47 µM -1.05086586824848 0.117138795275646 no 3003 0.146660099210069 4200 17027303 SGTC_1262 0737-0114 49.6 µM -1.05199097839088 0.116889571033629 no 3004 0.146401844377165 4220 765919 SGTC_1920 st075728 45.7 µM -1.05304621663981 0.116656165944945 no 3005 0.146159905378797 4123 3400306 SGTC_612 0302-0167 22.4 µM -1.05434750853829 0.11636879226063 no 3006 0.145861922582731 4150 235821 SGTC_2173 5763948 167 µM -1.05477582495807 0.116274314004584 no 3007 0.145763931788862 4121 2867177 SGTC_1327 1436-0082 2.18 µM -1.05564327954919 0.116083137192412 no 3008 0.145565609974432 4157 15992205 SGTC_919 tnp00227 403.569 nM -1.05720309962224 0.115739932670262 no 3009 0.145209452756555 4117 1269246 A methoxyflavone. YNL221C POP1 SGTC_339 3091-4833 71.4 µM -1.05888990215202 0.115369600170614 no 3010 0.144824961786579 4017 3240077 SGTC_842 0271-0008 11.1 µM -1.05902809196405 0.115339298371695 no 3011 0.144793493112488 4200 1221709 SGTC_1581 himbacine 57.9 µM -1.060973010619 0.114913423079731 no 3012 0.144351083430799 4147 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3335 9143315 29.6265 µM -1.06326324761902 0.114413369522302 no 3013 0.143831293568289 4159 4899691 SGTC_66 0109-0187 42.4 µM -1.0639384521888 0.114266240531981 no 3014 0.143678291139359 4051 759417 SGTC_1201 1889-3372 45.9 µM -1.06542849491729 0.113942032845834 no 3015 0.143341033851308 4026 5392199 SGTC_3193 9111931 49.47 µM -1.06557823886898 0.113909487416052 no 3016 0.143307170288215 4168 17087244 SGTC_2465 5809242 33.21 µM -1.06865684493333 0.113241849041575 no 3017 0.142612161983668 4208 2731748 SGTC_1792 st045773 43.6 µM -1.07022562160695 0.112902713845088 no 3018 0.142258882100951 4121 2919270 SGTC_1301 naphtanilide LB 4.81 µM -1.07237115178067 0.112440071873672 no 3019 0.141776679988544 4224 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1638 st008370 60.6 µM -1.07338688142554 0.112221522472612 no 3020 0.141548784013208 4117 24207134 SGTC_413 propylparaben 100 µM -1.07996915406507 0.110812604727887 no 3021 0.140077958158502 4125 7175 A pharmaceutical preservative. SGTC_2557 derrustone 83.84 µM -1.08252065280221 0.11026988609197 no 3022 0.139510621746156 4168 629853 An antioxidant. SGTC_786 4544-0069 423 µM -1.08369342602935 0.110021070888794 no 3023 0.13925037569086 4175 748821 YLR208W SEC13 SGTC_1211 1056-0033 32.3 µM -1.08460641612411 0.109827650241845 no 3024 0.139048006040242 4226 6741922 SGTC_2306 7482397 179.52 µM -1.08628682979858 0.109472286037944 no 3025 0.138676055987291 4193 891448 SGTC_1238 0333-0287 48.8 µM -1.09374489577895 0.107905062950719 no 3026 0.137033438922941 4155 7226 SGTC_1524 corynanthine 62.1 µM -1.09748696548109 0.107124827708276 no 3027 0.136214287803695 4307 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2235 salicylic acid 500 µM -1.09831006532689 0.106953755622589 no 3028 0.13603455911834 4220 338 A COX inhibitor and kinase inhibitor. SGTC_554 4483-2211 187 µM -1.1008322404278 0.106430777143592 no 3029 0.135484838542289 4251 747107 SGTC_751 0833-0568 350 µM -1.10443267069635 0.105687423130922 no 3030 0.134702747580138 4220 6954252 SGTC_677 0929-0063 136 µM -1.1079757927424 0.104959572792067 no 3031 0.13393613525228 4184 1539583 SGTC_1378 2093-0007 380 nM -1.11051081574002 0.104441044004226 no 3032 0.133389485023433 4260 3618014 SGTC_2446 5162541 200 µM -1.11158785213764 0.104221303258401 no 3033 0.133157698998707 4163 1549321 SGTC_199 4063-0024 41.6 µM -1.11317190860809 0.103898727689943 no 3034 0.132817302464622 4216 306215 SGTC_2254 7938975 95.19 µM -1.11344595704579 0.103842994311418 no 3035 0.132758473287095 4293 2969277 SGTC_3057 9095946 49.47 µM -1.11598718573999 0.10332721586003 no 3036 0.13221380988353 4257 24540043 SGTC_479 n-linoleoylglycine 10 µM -1.11600009453604 0.103324600592976 no 3037 0.132211047070133 4247 6433346 An anti-infammatory. SGTC_45 0kpi-0036 14.9 µM -1.11648290285756 0.103226820193537 no 3038 0.132107742289671 4243 2795021 SGTC_659 k018-0002 107 µM -1.11759469277517 0.103001911305065 no 3039 0.131870068244803 4208 6797879 YHR007C ERG11 SGTC_2146 5545642 200 µM -1.11767917068662 0.102984836458066 no 3040 0.131852020957084 4168 825326 SGTC_510 ag-490 170 µM -1.1242627777828 0.10166046161881 no 3041 0.130450782085391 4338 5328779 SGTC_1235 benzylparaben 21.5 µM -1.12602863051531 0.101307356686739 no 3042 0.130076700445966 4244 7180 SGTC_354 2783-3500 4.88 µM -1.12632502571969 0.101248176344151 no 3043 0.130013984354468 4222 6740761 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.12677989497588 0.101157402961889 no 3044 0.129917776473719 4224 5106787 A p450 inhibitor. SGTC_2383 9036125 200 µM -1.13119056569869 0.10028028688992 no 3045 0.128987445961548 4139 79580 SGTC_850 0388-0143 75.9 µM -1.13229638766417 0.100061253502705 no 3046 0.128754924150824 4201 67273 SGTC_691 1548-0686 185 µM -1.13383265316912 0.0997575409429974 no 3047 0.12843237560824 4206 46495133 SGTC_1777 st045864 34.765 µM -1.13687097954159 0.0991588620178442 no 3048 0.127796112727814 4217 4691462 SGTC_2552 juarezic acid 87.02 µM -1.13969565101993 0.0986046429115113 no 3049 0.127206559824795 4190 1549512 SGTC_1775 st081588 35.1725 µM -1.14443270532019 0.0976802974686343 no 3050 0.126222115619184 4241 1426443 YGL099W LSG1 SGTC_2867 9039098 71.43 µM -1.14919245274209 0.0967579388792651 no 3051 0.125238316133287 4205 6463460 SGTC_1868 st057644 42.7 µM -1.1501781810102 0.0965677234861454 no 3052 0.125035245464134 4261 688665 SGTC_2120 5538279 151.968 µM -1.15136529013574 0.0963390125483453 no 3053 0.124790993577172 4204 2058197 SGTC_3286 9117135 37.221 µM -1.15552766847844 0.0955402251022163 no 3054 0.123937204465118 4229 3438150 SGTC_2477 5967686 25.23 µM -1.15945215588073 0.0947915648033343 no 3055 0.123135963878343 4230 776118 SGTC_1529 apigenin 74 µM -1.16452401113076 0.0938304406915132 no 3056 0.122105859261582 4277 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2710 st078562 53.7235 µM -1.16820303745601 0.0931377744498395 no 3057 0.121362437786369 4199 17250908 SGTC_951 1171-0579 82.7 µM -1.16838930688291 0.0931028054722541 no 3058 0.121324883119611 4207 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1210 3013-0140 750 nM -1.17217387621832 0.0923944157290994 no 3059 0.120563627224444 4280 905973 SGTC_1016 4226-1401 38 µM -1.17299216765365 0.0922417750169725 no 3060 0.120399473299127 4242 2901613 SGTC_2957 9076800 11.52 µM -1.1752943919545 0.0918133289855083 no 3061 0.119938478688843 4232 16459615 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.1772813341778 0.0914447438570412 no 3062 0.119541617278946 4358 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_573 3702-0553 84.7 µM -1.17755043612463 0.091394908898814 no 3063 0.119487939577243 4223 1222756 SGTC_1711 st032263 62.8 µM -1.17864934065086 0.0911916118530727 no 3064 0.119268917860059 4271 3958979 SGTC_1461 k072-0203 53.8 µM -1.18072975096965 0.0908076551677021 no 3065 0.118855049378043 4176 5418714 SGTC_2597 laccaic acid a 100 µM -1.18206423377963 0.0905619978049646 no 3066 0.11859010731902 4263 5491415 A textile dye. SGTC_1531 st059297 52.4 µM -1.18243142764246 0.0904944897994355 no 3067 0.118517279613904 4297 7566702 SGTC_2912 7964298 10.93 µM -1.18583851794492 0.0898698824633785 no 3068 0.117843038510783 4276 2975850 SGTC_154 3389-1638 511.116 µM -1.18934979749892 0.0892295331218015 no 3069 0.11715102358031 4271 5238686 SGTC_409 arachidonic acid 100 µM -1.18985741169572 0.0891372414915807 no 3070 0.117051219925184 4263 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_303 1348-1668 34.2 µM -1.19047283393248 0.0890254440900243 no 3071 0.116930300603575 4289 5380509 SGTC_2731 amoxapine 43.43 µM -1.19207414751894 0.0887350391221784 no 3072 0.116616086437914 4425 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_981 1488-1094 54.9 µM -1.19400783775189 0.0883852972768372 no 3073 0.116237451081459 4246 3449522 SGTC_3206 9114350 49.47 µM -1.19521867806604 0.0881668191337793 no 3074 0.116000801391326 4141 17087243 SGTC_3078 9116413 49.47 µM -1.19600276688617 0.0880255568662598 no 3075 0.115847739664572 4209 17177322 SGTC_1804 st050076 49.1 µM -1.20114582528356 0.0871031593735866 no 3076 0.114847319878682 4304 3895976 SGTC_2366 9070441 60.58 µM -1.20718427698686 0.0860294103537463 no 3077 0.113680592107358 4267 6837235 SGTC_3022 9087993 49.47 µM -1.20989272946116 0.0855510270312598 no 3078 0.113160028721849 4366 17173644 SGTC_1190 1486-1332 13 µM -1.21270112015384 0.0850570985334563 no 3079 0.11262205571199 4287 4150046 SGTC_333 3486-0131 40.1 µM -1.21296078835521 0.0850115372986149 no 3080 0.112572406293722 4335 6744690 SGTC_1231 0242-0792 125 µM -1.21347616735274 0.084921163379842 no 3081 0.112473910437146 4289 3707635 SGTC_1017 4239-0030 168 µM -1.2151215132406 0.0846331269115548 no 3082 0.112159874763177 4309 1149593 SGTC_999 SEC7.066 22.7 µM -1.21581179455596 0.0845125037650522 no 3083 0.112028312384616 4255 740511 YDR170C SEC7 SGTC_816 0325-0417 81.3 µM -1.21807721517277 0.084117539207405 no 3084 0.111597315729577 4323 68101 SGTC_233 rapamycin 362 pM -1.22140283189463 0.0835402472877791 no 3085 0.110966767753128 4297 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3263 9137018 49.47 µM -1.2245640381195 0.0829942601905028 no 3086 0.110369762219434 4265 43844957 SGTC_1481 3346-2004 36 µM -1.22514399277422 0.0828943854733863 no 3087 0.110260486118762 4380 2770522 SGTC_3094 9117742 49.47 µM -1.2279393202521 0.0824142664809107 no 3088 0.109734873771956 4251 17149698 SGTC_775 4577-0580 57.3 µM -1.22996195886495 0.0820681704794281 no 3089 0.109355675240158 4356 2006902 SGTC_2787 5284540 71.43 µM -1.2327942197388 0.0815853807683515 no 3090 0.108826274225189 4341 736958 SGTC_2008 4012253 172 µM -1.23776491417015 0.0807432537126696 no 3091 0.107901620757403 4310 603940 SGTC_1931 st074438 57.1 µM -1.23832755211603 0.0806483475493176 no 3092 0.107797315832737 4319 2787313 SGTC_1157 4092-0394 27.6 µM -1.23909836553663 0.080518463008183 no 3093 0.107654536125948 4388 3659885 SGTC_2598 perillyl alcohol 100 µM -1.24033329716178 0.0803107025244913 no 3094 0.10742607074048 4344 10819 An apoptosis inducer. SGTC_179 1273-0063 6.77 µM -1.24129009404625 0.0801500131555477 no 3095 0.107249301389251 4282 3108139 SGTC_3290 9121031 71.43 µM -1.24190886587628 0.0800462229283365 no 3096 0.10713509429287 4328 17014854 SGTC_1475 4092-1048 11.7 µM -1.24369667936664 0.0797469134253908 no 3097 0.106805609298626 4312 2881759 SGTC_3223 9129970 49.47 µM -1.24549681265837 0.0794463975110205 no 3098 0.106474593202513 4325 17248386 SGTC_1676 st018489 23.4 µM -1.24613311195624 0.0793403783872621 no 3099 0.106357765168045 4338 3696235 SGTC_648 0375-0473 33.3 µM -1.24662955998992 0.0792577354480918 no 3100 0.106266678899096 4292 1713139 SGTC_1951 sophoraflavanone G 9.2 µM -1.25288460423875 0.0782220442913943 no 3101 0.105123852811721 4270 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1612 st002233 45.4 µM -1.25746726669246 0.0774697994164242 no 3102 0.10429224239183 4343 1035021 SGTC_1835 st008666 49.2 µM -1.259731166733 0.0771002132001891 no 3103 0.103883179103194 4273 690455 SGTC_40 0327-0103 19.753 µM -1.26211243966988 0.0767129131171364 no 3104 0.103454164833787 4178 409036 SGTC_988 1497-1057 103 µM -1.26380133028634 0.0764391229459181 no 3105 0.103150671804264 4307 3533044 SGTC_3140 9094243 49.47 µM -1.26416797177083 0.0763797841340166 no 3106 0.103084871967324 4297 19291112 SGTC_1977 st070720 65.3 µM -1.26564426747516 0.076141208823824 no 3107 0.102820234960254 4370 682188 SGTC_2830 7992007 71.43 µM -1.2733207043817 0.0749098001802593 no 3108 0.10145213132591 4220 1952075 SGTC_1097 itavastatin 7.23 µM -1.2733390389937 0.0749068773450393 no 3109 0.10144887965944 4359 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1550 gossypolone 36.6 µM -1.27336529027534 0.0749026926154257 no 3110 0.101444224093819 4372 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_582 0987-0078 156 µM -1.27336534003817 0.0749026846828787 no 3111 0.101444215268718 4399 1625765 SGTC_574 1315-0397 40 µM -1.27365638423946 0.0748563011368665 no 3112 0.101392610109046 4320 6794277 SGTC_689 0833-0039 98 µM -1.2759776867141 0.07448714052234 no 3113 0.10098170344711 4297 5374726 SGTC_2216 7189485 200 µM -1.28129047480252 0.0736474710145682 no 3114 0.100045828655933 4346 731273 SGTC_593 1203-0218 61.7 µM -1.28243266569929 0.073467900061961 no 3115 0.0998454556828212 4383 3666956 SGTC_2661 dactinomycin 12.96 µM -1.28445467009222 0.0731508294573388 no 3116 0.0994914573070631 4317 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2849 9019321 12.99 µM -1.28569454247908 0.0729569235230287 no 3117 0.0992748433269073 4386 16489627 SGTC_707 0865-0008 204 µM -1.28799179294865 0.0725986923865543 no 3118 0.0988744100389762 4396 723043 SGTC_802 4112-3352 742 µM -1.28862542735848 0.072500121446498 no 3119 0.0987641695670888 4405 704594 SGTC_2266 7929956 200 µM -1.29028530266529 0.0722423900522066 no 3120 0.0984758089798997 4300 2967153 SGTC_733 4069-0007 56.1 µM -1.29099973046877 0.0721316761368375 no 3121 0.0983518854878457 4377 5717425 YNL287W SEC21 SGTC_1905 st060207 84.5 µM -1.29932533397851 0.0708510398603471 no 3122 0.0969161518595344 4348 1948547 SGTC_2101 5377231 179.231 µM -1.29993319578861 0.0707582277633424 no 3123 0.0968119332263744 4397 2844213 SGTC_3049 9092223 49.47 µM -1.29994177070562 0.070756919160567 no 3124 0.0968104636354914 4348 8623917 SGTC_406 estrone 100 µM -1.30109320923235 0.0705813690252979 no 3125 0.096613275955293 4337 5870 A steroid. SGTC_590 k048-0076 22.4 µM -1.30176083018262 0.0704797359145401 no 3126 0.0964990788546319 4394 6832814 SGTC_527 4476-4215 268 µM -1.30494884419211 0.0699959695759415 no 3127 0.0959551337771611 4370 4418754 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.30497493460838 0.069992021042796 no 3128 0.0959506915016188 4423 165506 SGTC_50 0929-0078 56.389 µM -1.3081144735567 0.0695181320082903 no 3129 0.0954172425066182 4216 1377751 SGTC_2864 9034755 47.6 µM -1.31160560844227 0.0689940777623369 no 3130 0.0948266198614559 4301 4930451 SGTC_3141 9094609 49.47 µM -1.31290377741815 0.0687999881111974 no 3131 0.094607686937751 4340 25236309 YDL196W YDL196W SGTC_1006 4099-6547 255 µM -1.31331576937264 0.0687384791469201 no 3132 0.0945382834824385 4380 3146833 SGTC_92 0063-0024 660.874 µM -1.31488920055087 0.0685039614975541 no 3133 0.0942735713748948 4475 3594437 SGTC_1559 coumarin 343 70.1 µM -1.31535714770329 0.0684343338615153 no 3134 0.0941949500981529 4415 108770 A hepatotoxic, DNA x-linker. SGTC_2240 6690706 185.951 µM -1.31626971875847 0.0682987060233653 no 3135 0.0940417653116219 4276 805876 SGTC_2293 7624732 200 µM -1.31778232495227 0.0680743569338779 no 3136 0.093788263197198 4264 894453 SGTC_780 0109-0199 192 µM -1.32407033179122 0.0671478164687263 no 3137 0.0927398438417934 4433 610414 SGTC_2601 securinine 100 µM -1.32511724630834 0.0669945045972082 no 3138 0.0925661334130509 4359 442872 A GABA receptor antagonist. SGTC_799 1310-0557 151 µM -1.32915556148541 0.0664056624841742 no 3139 0.0918983263424142 4415 5354492 SGTC_952 1185-0122 232 µM -1.33034038919159 0.0662336607825671 no 3140 0.0917030727241204 4341 678600 SGTC_1520 flindersine 88 µM -1.33069270378965 0.0661825818067062 no 3141 0.0916450723853454 4426 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1965 Pectolinarigenin 58.4 µM -1.33309955882436 0.0658344490241022 no 3142 0.0912495670763045 4369 5320438 An anti-inflammatory. SGTC_191 3914-0123 66.505 µM -1.33590170062348 0.0654309310876886 no 3143 0.0907907025169205 4416 3144412 SGTC_633 0437-0093 97.7 µM -1.33787830308872 0.0651474493241937 no 3144 0.0904680555061952 4324 2831118 SGTC_1381 2324-0066 62.1 µM -1.34135046574032 0.0646517849532826 no 3145 0.0899033460072251 4427 10885928 SGTC_3349 9149703 23.001 µM -1.34298384243279 0.0644196295770918 no 3146 0.0896386028964229 4411 4910494 SGTC_1425 4048-4433 7.33 µM -1.35201544074551 0.0631476228941109 no 3147 0.0881851879115873 4464 23734946 SGTC_2728 chlorpromazine 9.18 µM -1.35459287996843 0.0627882281965525 no 3148 0.0877736516003133 4489 2726 A thorazine and dopamine antagonist. SGTC_1478 0453-0656 35.7 µM -1.35530982858786 0.0626885417077082 no 3149 0.0876594324383683 4416 5258496 SGTC_2419 paclitaxel 166.5 µM -1.35563306876261 0.0626436378760937 no 3150 0.0876079723940356 4353 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_560 2332-1943 155 µM -1.36196394666524 0.0617692106091783 no 3151 0.0866046317227658 4404 21177716 SGTC_481 bay k-8644 50 µM -1.36463522600061 0.0614031215738686 no 3152 0.0861838637157895 4368 2303 A calcium channel antagonist. SGTC_463 ikarugamyin 104 µM -1.36602523938923 0.0612132969276597 no 3153 0.0859655207918629 4553 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3241 9133421 49.47 µM -1.36697230840852 0.0610842250447016 no 3154 0.0858169927132037 4501 17018221 SGTC_1324 1418-0026 34.4 µM -1.37379021806149 0.0601613101496793 no 3155 0.0847534094053236 4455 1372513 SGTC_982 1491-0518 27.5 µM -1.37487420195617 0.0600155864077099 no 3156 0.0845852242776463 4356 3091256 SGTC_835 0312-0010 67.2 µM -1.37634824427682 0.0598178694225737 no 3157 0.0843569216158286 4433 1626196 SGTC_1831 st055328 12 µM -1.37938532228788 0.0594121075464021 no 3158 0.0838879911356896 4406 1103068 SGTC_1068 loratadine 26.9 µM -1.38049404674535 0.0592645177203502 no 3159 0.0837172906896517 4473 3957 A H1 histamine antagonist. SGTC_2365 9042475 200 µM -1.38135856073746 0.0591496360110892 no 3160 0.0835843703156725 4465 6464479 SGTC_1075 aripiprazole 15.2 µM -1.38549462611069 0.0586024262654318 no 3161 0.0829506372900815 4479 60795 An atypical antipschotic. YIL048W NEO1 SGTC_126 0417-1624 672.48 µM -1.38755163890879 0.0583317631698862 no 3162 0.0826368081988464 4476 41912 YDL195W SEC31 SGTC_3138 9097216 49.47 µM -1.38760256654752 0.0583250745545561 no 3163 0.0826290497522311 4361 25237486 SGTC_877 0771-0151 33.1 µM -1.39290470421084 0.0576320049462332 no 3164 0.0818243048584758 4444 6166523 SGTC_197 4544-0043 41.561 µM -1.39654676068888 0.0571596973055895 no 3165 0.0812749548248021 4449 896523 SGTC_2024 5144227 134 µM -1.39701679832117 0.0570989646896171 no 3166 0.081204259844815 4411 3475211 SGTC_1486 3970-0793 4.53 µM -1.3988266750618 0.0568655883992693 no 3167 0.0809324825317751 4465 2844330 SGTC_962 1254-0300 21.5 µM -1.40596195691761 0.0559528335156576 no 3168 0.0798677108826916 4411 7340576 SGTC_678 1218-2179 85.9 µM -1.40680646050056 0.055845572674633 no 3169 0.0797423931713343 4479 6820081 YOR116C RPO31 SGTC_3031 9088762 49.47 µM -1.40711881290202 0.0558059417547293 no 3170 0.079696080223053 4419 205253 SGTC_430 0958-0115 16.4 µM -1.40776924424876 0.0557234869786861 no 3171 0.079599705121032 4371 6833180 SGTC_1180 1193-0155 285 µM -1.40925342490431 0.0555356983077464 no 3172 0.0793801227081969 4484 2921347 SGTC_2558 carylophyllene oxide 100 µM -1.41609423361657 0.0546766023939606 no 3173 0.0783739580930341 4557 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1255 0566-0045 221 µM -1.43012153068295 0.0529478811652015 no 3174 0.0763410708461172 4470 2788469 SGTC_424 splitomicin 100 mM -1.43577983280275 0.0522629430890862 no 3175 0.0755325000894375 4460 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1926 methyl fluorone black 53.6 µM -1.43662092436037 0.0521617322641964 no 3176 0.0754128673845932 4093 72721 Reacts with homocysteine. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.43712472573549 0.0521011830710864 no 3177 0.0753412783571814 4409 6708514 SGTC_2089 5281248 129.67 µM -1.43721437410165 0.0520904145670323 no 3178 0.0753285449594448 4445 2737878 SGTC_2776 terbinafine 19.92 µM -1.43991959888167 0.051766295558483 no 3179 0.0749450737321433 4469 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3099 9120367 49.47 µM -1.44462823407934 0.0512059687083787 no 3180 0.0742811688976683 4501 24824940 SGTC_136 0097-0015 404.482 µM -1.44588453073048 0.0510572880242612 no 3181 0.0741047957268203 4456 4861337 SGTC_1167 k781-0610 148 µM -1.45049670788005 0.0505143883467964 no 3182 0.0734600282855297 4495 4525169 SGTC_2725 haloperidol 53.21 µM -1.45127627164619 0.0504230818623692 no 3183 0.0733514729355745 4432 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1962 st076595 64.5 µM -1.45222016256849 0.0503127046024033 no 3184 0.0732201990754952 4436 279619 SGTC_1082 camptothecin 424.86 nM -1.46125309706894 0.0492661188655606 no 3185 0.0719729981706829 4341 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2340 7987427 183.45 µM -1.46285985598734 0.0490817886031516 no 3186 0.0717528652929517 4472 2239331 SGTC_486 niguldipine 82 µM -1.46310548036605 0.0490536587415083 no 3187 0.0717192592540799 4547 1236 A calcium channel blocker. SGTC_87 0100-0052 35.5 µM -1.46749489170843 0.0485531343836021 no 3188 0.0711207389337132 4494 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_561 1550-0330 72.9 µM -1.46820829125492 0.0484721725945606 no 3189 0.071023826388004 4432 6812934 SGTC_1949 st076024 69.1 µM -1.47910670675202 0.0472487132285089 no 3190 0.069555899001793 4447 2921930 SGTC_2755 lomerizine 42.69 µM -1.48279328859755 0.0468405033956265 no 3191 0.0690646698745096 4420 3949 A calcium channel blocker. SGTC_3242 9133940 49.47 µM -1.49011014303989 0.0460386996675719 no 3192 0.0680976388223797 4494 17248444 SGTC_1455 4262-0120 131 µM -1.49658960342546 0.0453378995376254 no 3193 0.0672500384983318 4533 1529587 SGTC_2153 5569715 200 µM -1.4972790471887 0.0452638390620743 no 3194 0.0671603322489467 4506 2054701 SGTC_1848 st056003 16.4 µM -1.50009666015412 0.0449621804111409 no 3195 0.066794682985656 4494 146492 SGTC_2979 9012552 45.46 µM -1.5035989019112 0.0445894823191093 no 3196 0.0663423370306566 4502 17100905 SGTC_2973 9094665 17.96 µM -1.50393949220098 0.0445533708798401 no 3197 0.0662984736055151 4485 25237061 YIL048W NEO1 SGTC_801 0866-0028 10.1 µM -1.5074924637586 0.0441780664817536 no 3198 0.0658422370573652 4531 6849771 SGTC_1108 betulinic acid 729.144 nM -1.50820858648253 0.0441027311114982 no 3199 0.065750575190573 4496 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2484 5809818 12.04 µM -1.5109025071799 0.0438202606674129 no 3200 0.0654066459986459 4477 2870548 SGTC_2529 gangaleoidin 93.61 µM -1.51999773013737 0.0428773489368281 no 3201 0.0642557730608905 4493 4565183 SGTC_948 3448-0295 75.3 µM -1.52364647142581 0.0425037181675796 no 3202 0.0637985238880968 4482 678569 SGTC_1458 k015-0034 6.33 µM -1.52424698485032 0.0424424787330917 no 3203 0.0637235125206213 4535 3598957 SGTC_3134 9127454 49.47 µM -1.5332049481144 0.0415374037259965 no 3204 0.0626126827427633 4557 24262820 SGTC_2620 irigenin 100 µM -1.53352317768862 0.0415055410290171 no 3205 0.0625735001787754 4499 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_614 0462-0418 107 µM -1.53958854795422 0.0409020235422044 no 3206 0.0618303393630999 4287 5188303 SGTC_1693 xanthone 101.9 µM -1.54329165683636 0.040537069366133 no 3207 0.0613800135082339 4567 7020 An insecticide. SGTC_1947 st076332 61.6 µM -1.54330914894808 0.0405353517516811 no 3208 0.0613778924324175 4387 24208416 SGTC_187 1488-2104 32.728 µM -1.54736657000464 0.0401385321350949 no 3209 0.0608874388153455 4510 2852859 SGTC_2526 patulin 37.61 µM -1.557953228176 0.0391179913439658 no 3210 0.0596221679539611 4535 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_140 0062-0056 502.533 µM -1.56309238594425 0.0386302532978293 no 3211 0.0590154331391322 4438 3758964 SGTC_1356 1502-0781 85.8 µM -1.57315167950645 0.0376899069244248 no 3212 0.0578418504432674 4538 567702 SGTC_1189 1431-2119 7.28 µM -1.57387904811033 0.0376226430193496 no 3213 0.0577577072887486 4528 3107275 SGTC_145 3737-0113 38.366 µM -1.57642418321834 0.0373880509863168 no 3214 0.057464039377426 4520 6849351 SGTC_2925 9010536 32.5 µM -1.58214830804921 0.0368648068021841 no 3215 0.0568078588583607 4457 2994177 SGTC_317 4495-0002 170 µM -1.59252112691689 0.0359318861038372 no 3216 0.0556338299543794 4546 15991618 SGTC_1637 st007924 17.4 µM -1.59695425262486 0.035539117971128 no 3217 0.055137952527719 4455 683336 SGTC_2495 cafestol 54.53 µM -1.5972920930344 0.0355093307313817 no 3218 0.0551003062575888 4529 16667697 An anti-infammatory. SGTC_1128 3448-9350 235 µM -1.59944836022636 0.0353196955087742 no 3219 0.0548605070516728 4528 619386 SGTC_2486 5283202 22.39 µM -1.60016633915492 0.0352567367226855 no 3220 0.0547808436767507 4547 1377751 SGTC_1915 st067105 30.6 µM -1.60240798741873 0.035060761205316 no 3221 0.0545327098533922 4488 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2984 9022109 38.96 µM -1.61072117705264 0.034341772825757 no 3222 0.053620253925554 4565 6459207 SGTC_529 4076-0302 30.3 µM -1.61811349527003 0.0337126483574439 no 3223 0.0528190703386429 4521 5816522 SGTC_2900 5328528 85.29 µM -1.61933280755114 0.0336097954209734 no 3224 0.0526878377123659 4543 795359 SGTC_526 4469-0568 170 µM -1.62458434797273 0.0331697583927144 no 3225 0.0521255772195239 4523 2901964 SGTC_2436 5633522 8.09 µM -1.62817040700112 0.0328720108151251 no 3226 0.051744378895153 4539 5724242 SGTC_1628 st004252 77.7 µM -1.63018517934023 0.0327056947673421 no 3227 0.0515311826477943 4550 692968 SGTC_668 1682-0499 62.6 µM -1.63273610598214 0.0324961161016516 no 3228 0.0512622551107808 4550 682214 SGTC_120 rhodamine 6G 52.259 µM -1.63392000507273 0.0323992265611878 no 3229 0.0511378242931248 4554 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1252 0493-0875 34.8 µM -1.64361542251525 0.0316146958723108 no 3230 0.0501278331072212 4555 3960963 SGTC_2444 5485484 36.41 µM -1.64643150453014 0.0313897898690839 no 3231 0.0498374756502366 4600 6790631 SGTC_2344 7990960 76.95 µM -1.64725943304705 0.0313239196712143 no 3232 0.0497523661781213 4553 140813 SGTC_1786 berberine 21.6 µM -1.6479212377601 0.0312713485637361 no 3233 0.0496844173388439 4471 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_755 1995-0008 37.3 µM -1.65014154590175 0.0310955090046009 no 3234 0.0494569945429444 4548 689533 SGTC_703 3875-0075 71.8 µM -1.65744888368818 0.0305225643003577 no 3235 0.0487143776281344 4609 2850814 SGTC_1429 4049-0205 9.46 µM -1.66111462588604 0.0302384554742081 no 3236 0.0483452137790267 4625 22774478 SGTC_2621 lithochol-11-enic acid 100 µM -1.66545406470216 0.0299049693057467 no 3237 0.0479111003922354 4522 6708711 SGTC_1047 2043-3044 82 µM -1.66722318443845 0.0297698904516878 no 3238 0.0477350171464992 4539 669592 SGTC_596 1155-0152 116 µM -1.66953383407445 0.0295942265087637 no 3239 0.0475058154400247 4592 280313 SGTC_1135 dihydrocapsaicin 536.708 nM -1.66967324117739 0.0295836558523592 no 3240 0.0474920153939273 4490 107982 A Capsaicinoid. SGTC_381 3461-2219 42.7 µM -1.67398832241757 0.0292580078447709 no 3241 0.0470664471975541 4561 2883159 SGTC_2702 st077768 96.8 µM -1.67874389563206 0.028902571385648 no 3242 0.046600983538809 4537 6484119 SGTC_1901 st060216 58.6 µM -1.67996097954828 0.0288121843279216 no 3243 0.0464824539862376 4554 688792 SGTC_1824 st053723 68.6 µM -1.68084402852903 0.0287467516697196 no 3244 0.0463966070492403 4588 675225 SGTC_2367 9070478 135.38 µM -1.68362941288567 0.0285411677357557 no 3245 0.0461266553588528 4525 572802 SGTC_509 pifithrin 175 µM -1.68636936913899 0.0283401314860313 no 3246 0.045862338712724 4664 4817 A p53 inhibitor. SGTC_2133 5320837 200 µM -1.70481085941985 0.0270174859357243 no 3247 0.0441148527702267 4599 2841355 SGTC_3088 9117578 49.47 µM -1.70919808807303 0.026710530865548 no 3248 0.0437071314569047 4651 678341 SGTC_709 3807-1509 243 µM -1.71130296691965 0.0265642988746387 no 3249 0.0435125994755381 4654 1886677 YPL242C IQG1 SGTC_517 1365-0151 113 µM -1.71177740865257 0.0265314305744279 no 3250 0.043468848435212 4582 768657 SGTC_448 monastrol 171 µM -1.71323982564237 0.0264303311962 no 3251 0.0433342138172554 4519 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1308 1187-1617 41.4 µM -1.71416460206478 0.0263665661419102 no 3252 0.0432492499648923 4613 2882570 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.71756084789294 0.0261334908573376 no 3253 0.0429383734148846 4560 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2172 5754775 163.918 µM -1.72883107151135 0.0253723566940015 no 3254 0.0419196666945128 4583 2263357 SGTC_3079 9117512 49.47 µM -1.73647243543179 0.0248669320027699 no 3255 0.0412401670719355 4669 7185044 SGTC_2699 st077704 54.6 µM -1.74750165407088 0.0241523327160653 no 3256 0.0402751791195252 4595 645852 SGTC_459 nigericin 15.3 µM -1.74776702474187 0.0241353537256487 no 3257 0.0402521887321628 4617 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1297 1068-0111 14.1 µM -1.75212681804586 0.0238578371748122 no 3258 0.0398760018999518 4609 767057 SGTC_2987 9018338 71.43 µM -1.75919311575691 0.0234137405209555 no 3259 0.039272356584499 4617 5055682 SGTC_138 0850-0259 40.9225 µM -1.75993729063352 0.0233673787242065 no 3260 0.0392092198527743 4558 6813004 SGTC_1371 2421-0008 32.7 µM -1.76696217758848 0.0229335256018547 no 3261 0.0386172813643717 4606 2827552 SGTC_129 0088-0017 176.636 µM -1.76999733946802 0.0227481857827181 no 3262 0.0383637919675784 4481 182446 SGTC_1986 st071812 45 µM -1.77445225802229 0.0224784367918972 no 3263 0.0379941862067544 4573 11838594 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.78115899398855 0.0220774285355416 no 3264 0.0374432402277433 4565 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3274 9138298 49.47 µM -1.78206514557103 0.0220237139122214 no 3265 0.0373693044122065 4587 17015756 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.78983799003754 0.0215674732425433 no 3266 0.036739979965533 4639 15053 SGTC_3268 9137683 49.47 µM -1.80250750594535 0.0208409412096377 no 3267 0.0357327974222774 4667 1953228 SGTC_1438 4092-1045 4 µM -1.80887043881407 0.0204839449983815 no 3268 0.0352355669524489 4656 1351342 SGTC_1699 st031318 29.054 µM -1.82061270942277 0.0198387349456229 no 3269 0.0343328747503635 4680 5340658 SGTC_1042 0350-0096 82 µM -1.82436191227186 0.019636392450729 no 3270 0.0340486880692337 4621 3122515 SGTC_1243 0416-0003 5.65 µM -1.82700349451306 0.0194948822504899 no 3271 0.0338496219894518 4615 2141977 SGTC_1258 0671-0043 57.1 µM -1.82901078047975 0.0193879315007584 no 3272 0.0336989966382552 4635 4298767 SGTC_912 3474-0017 2.18 µM -1.8361186559219 0.0190132140740933 no 3273 0.0331700548559348 4635 3360550 SGTC_868 0527-0199 213 µM -1.85154967942619 0.0182208677145988 no 3274 0.0320452573186666 4632 2849450 SGTC_1960 st011366 51.8 µM -1.85155616686015 0.0182205406101043 no 3275 0.0320447911443189 4682 3972846 SGTC_785 1270-0111 65.3 µM -1.87017513415727 0.0173021337025227 no 3276 0.0307297507760359 4571 6741994 SGTC_1685 st024049 53.0905 µM -1.879766718214 0.0168446484087875 no 3277 0.0300699391002652 4680 1941139 SGTC_2927 9011802 47.9 µM -1.88172138165465 0.0167526975996516 no 3278 0.0299369275345766 4615 43912568 SGTC_2043 5101342 149 µM -1.88293799765735 0.0166956829078962 no 3279 0.0298543855053506 4666 678451 SGTC_2975 9084847 53.72 µM -1.90322250980351 0.0157692644753048 no 3280 0.0285057585771835 4626 27211724 SGTC_2502 avocadyne acetate 18.59 µM -1.9064461856701 0.0156261722721096 no 3281 0.0282961706776278 4629 3952079 SGTC_1065 prochlorperazine maleate 2.48 µM -1.91154133369738 0.0154022816428888 no 3282 0.0279675251525738 4694 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_460 trequinsin 123 µM -1.91986337436328 0.015042518086891 no 3283 0.0274375796410872 4730 5537 A vasodilator. SGTC_1352 1496-0991 99 µM -1.9298057594689 0.014622196436372 no 3284 0.0268154548047408 4672 3000039 SGTC_60 0986-0278 202 µM -1.9348957514343 0.0144109521180414 no 3285 0.0265015448337801 4621 3110598 SGTC_264 promethazine 12.5 mM -1.94654872024207 0.0139372032563078 no 3286 0.0257944307752501 4545 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2733 amorolfine 100 µM -1.94857481384736 0.013856218062335 no 3287 0.0256731111720588 4771 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1303 1160-0052 261 µM -1.95694844135052 0.0135258048537365 no 3288 0.0251767652228399 4644 3562476 SGTC_2241 6772625 37.8075 µM -1.96252997224907 0.0133093613019509 no 3289 0.0248504073179132 4488 2285411 SGTC_2470 5664817 21.68 µM -1.96810542250914 0.0130961468621922 no 3290 0.0245279545382872 4722 2859561 SGTC_2482 5981709 142.65 µM -1.97431958996932 0.0128619917293221 no 3291 0.0241727073771095 4640 877755 SGTC_914 3820-6779 408 µM -1.98086504261218 0.0126192778319488 no 3292 0.0238032051333317 4607 2893481 SGTC_2238 6671620 73.2395 µM -1.98621049130702 0.0124240122452386 no 3293 0.0235049782081703 4598 729941 SGTC_1396 3511-0007 98.6 µM -1.99315159788292 0.0121743672823752 no 3294 0.0231224246875561 4693 X1396 SGTC_815 1582-0027 36.9 µM -2.00305348500688 0.0118257646129884 no 3295 0.0225857739726458 4688 3128206 SGTC_2990 9074105 71.4286 µM -2.0039276819796 0.0117954081523358 no 3296 0.0225389038690032 4612 6502001 SGTC_1904 st060225 78 µM -2.01011351188895 0.011582531114909 no 3297 0.0222095881531629 4671 66595 SGTC_2296 7971656 126.45 µM -2.014347317417 0.0114387605761532 no 3298 0.0219865406777852 4662 666570 SGTC_2364 9055074 200 µM -2.02927229293704 0.0109442365840383 no 3299 0.0212152818828395 4676 6470630 SGTC_1402 3909-7673 35.9 µM -2.03005155638566 0.0109189354340092 no 3300 0.0211756494831219 4695 5328014 SGTC_2629 bisabolol 100 µM -2.0336214319045 0.0108036782070683 no 3301 0.0209948896314471 4677 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_515 4092-1064 102 µM -2.03471442943398 0.010768602048334 no 3302 0.020939807726092 4655 717353 SGTC_2726 cimetidine 79.27 µM -2.07273292560526 0.00960867775712158 no 3303 0.019098570878401 4724 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2478 5763493 32.33 µM -2.08663166654255 0.00921274818453958 no 3304 0.0184607212659257 4672 1365576 YLR208W SEC13 SGTC_8 0354-0001 70 µM -2.09022887535371 0.0091126311306213 no 3305 0.0182986224256414 4704 4993152 SGTC_592 k241-0073 46.5 µM -2.09279935002829 0.00904167480371026 no 3306 0.0181835349366318 4737 4230158 SGTC_736 0958-0254 92.6 µM -2.0967330018405 0.00893402565453147 no 3307 0.0180086086837548 4725 6812352 SGTC_1350 1495-0454 146 µM -2.11526006422792 0.00844197127694355 no 3308 0.0172038940906643 4720 1069057 SGTC_1259 0671-0132 43 µM -2.1244678792487 0.00820639395233954 no 3309 0.0168155196058905 4661 X1259 SGTC_2907 7721985 69.9 µM -2.13564266832855 0.00792826510213858 no 3310 0.0163542753780043 4697 3267881 SGTC_932 2857-0803 154 µM -2.13576687064307 0.0079252209956978 no 3311 0.016349210369369 4691 674898 SGTC_2445 5742597 35.57 µM -2.14582307444843 0.00768213653810281 no 3312 0.0159435484815586 4704 1774255 SGTC_1126 isoteolin 1.0172 µM -2.15615137464758 0.00743933067252771 no 3313 0.0155359235096705 4674 133323 SGTC_3348 9149464 3.537 µM -2.15713921367243 0.00741646593122954 no 3314 0.0154974095059947 4686 1951442 SGTC_2427 5545055 42.75 µM -2.18515769062967 0.00679321596184793 no 3315 0.0144386432486408 4692 5372858 SGTC_698 k064-0052 127 µM -2.19683231153477 0.00654748946191455 no 3316 0.0140162122513505 4763 5088751 SGTC_2085 5307070 144.047 µM -2.20048279461806 0.00647228455163615 no 3317 0.0138863296641153 4683 2840351 SGTC_1435 4092-0789 56.7 µM -2.21332588822911 0.00621373748475968 no 3318 0.013437593025675 4742 2248285 SGTC_2627 acetyl isogambogic acid 100 µM -2.25142230445098 0.00549980767025768 no 3319 0.0121794013788512 4712 6857789 A caspase activator and apoptosis inducer. SGTC_2231 micatex 6.853 µM -2.25481307289393 0.00543994303112317 no 3320 0.0120725321834017 4735 20737 An antifungal of unknown mechanism. SGTC_3220 9131269 49.47 µM -2.29040210930143 0.00484569735318119 no 3321 0.0109990086875852 4742 17722206 SGTC_3273 9137859 49.47 µM -2.29743688753855 0.00473532992628856 no 3322 0.010796929756547 4762 2377234 SGTC_549 1661-1316 519 µM -2.30271260472954 0.0046540370551838 no 3323 0.0106475092634011 4758 2857282 SGTC_1446 4239-0190 62 µM -2.37330939495338 0.003679949082503 no 3324 0.00881474476310635 4752 1340085 SGTC_1349 flufenamic acid 69 µM -2.38267985013744 0.00356545574793057 no 3325 0.00859356711034816 4713 3371 A non-steroidal anti-inflammatory. SGTC_518 1021-0119 62.6 µM -2.38628609095222 0.0035222519227017 no 3326 0.00850975263992177 4730 1097762 SGTC_1426 4048-4480 71.7 µM -2.48246773977296 0.00253029391169159 no 3327 0.00652379408120017 4772 14224343 SGTC_2897 9048598 12.99 µM -2.48624949080742 0.00249704696720295 no 3328 0.006454871207834 4750 6467404 SGTC_2700 st077718 96.8 µM -2.5141839859633 0.00226344594864434 no 3329 0.00596540867976881 4744 904970 SGTC_2318 6029776 164 µM -2.51540025456116 0.00225374005022042 no 3330 0.00594486578730856 4748 818325 SGTC_1729 st035615 45.989 µM -2.52277229136339 0.00219571334574501 no 3331 0.00582168845321347 4738 17385451 SGTC_461 N-acetylfarnesylcysteine 136 µM -2.59229406901614 0.00171151548974367 no 3332 0.00476691198148069 4787 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1221 2958-7315 257 µM -2.63172908773693 0.00148221282586941 no 3333 0.00424757864190289 4787 4562705 SGTC_213 1246-0773 967 nM -2.64488817137828 0.00141217199139299 no 3334 0.0040858959325298 4780 6251622 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.64520287103248 0.00141053459499226 no 3335 0.00408209765648207 4757 61125 An anti-inflammatory. SGTC_3083 9117465 49.47 µM -2.65478883382006 0.0013614815497734 no 3336 0.00396790344434473 4748 16420915 SGTC_1242 0402-0103 60.1 µM -2.71681187413088 0.00107997179380579 no 3337 0.00329570308960236 4741 432868 SGTC_1250 0485-0349 40.2 µM -2.82203898629017 0.000721459240047173 yes 3338 0.00238596879106367 4760 6842794 YDL195W SEC31 SGTC_2301 7769476 200 µM -2.82439000145575 0.000714878518342065 yes 3339 0.00236853525812224 4771 977820 SGTC_2507 purpurin 79.67 µM -2.91046563310359 0.000508823154649463 yes 3340 0.00180445326747841 4778 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2332 7982454 138.89 µM -2.98249517463946 0.000380234918405863 yes 3341 0.00142954577671756 4759 2981748 SGTC_2992 9074591 71.4286 µM -2.99369773998261 0.000363189963955526 yes 3342 0.00137809421651825 4771 17741321 SGTC_2335 9018011 154.17 µM -3.03507669558951 0.000306194586104859 yes 3343 0.001202372634356 4785 6458208 SGTC_1934 st074720 32.6 µM -3.09444600672964 0.000238822447690594 yes 3344 0.000985904105200326 4764 17250992 SGTC_2775 cyproheptadine 69.59 µM -3.17397653221536 0.000170070494928946 yes 3345 0.00075182923897458 4793 2913 A selective serotonin reuptake inhibitor. SGTC_2971 9092186 9.93 µM -3.18199325496051 0.000164279526818974 yes 3346 0.000731326124014836 4771 25236400 SGTC_1443 4112-3303 14 µM -3.28589213573922 0.000104124843923832 yes 3347 0.00050829965432936 4802 704433 SGTC_3089 9117425 49.47 µM -3.35279328474853 7.71001493018782e-05 yes 3348 0.000400002161569973 4796 9401657 SGTC_1253 0550-0034 176 µM -3.45546307745295 4.81087138500597e-05 yes 3349 0.000274674213081558 4797 5969915 SGTC_47 0149-0135 24.25 µM -3.53227292194523 3.35247625729952e-05 yes 3350 0.000206001950951425 4805 5239155 SGTC_516 3992-2719 87.3 µM -3.53483132147024 3.31197979570022e-05 yes 3351 0.000204017769509386 4782 5350887 YDR037W KRS1 SGTC_2317 5986382 200 µM -3.55447117056878 3.01616842474717e-05 yes 3352 0.0001893700158467 4799 877883 SGTC_2263 7948595 193.29 µM -3.60602332792232 2.35415805451606e-05 yes 3353 0.000155462599001771 4806 2971371 SGTC_2292 7671323 168.05 µM -4.01253290710038 2.9788968933491e-06 yes 3354 3.00353509358056e-05 4804 937504 SGTC_2267 7931562 200 µM -4.3165263838392 5.56436957408025e-07 yes 3355 7.9251871675986e-06 4799 934880 SGTC_2274 7947094 46.08 µM -5.98309770437236 7.43545632377337e-12 yes 3356 1.09466673885095e-09 4809 2971028