SGTCid condition conc unit COA2|YPL189C-A.score COA2|YPL189C-A.strain.pval COA2|YPL189C-A.strain.significant COA2|YPL189C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1635 st007035 42.4 µM 21.2532037997788 4.8691090276552e-108 yes 1 1.53960438977121e-100 20 3716403
SGTC_386 1509-0011 3.07 µM 12.2417347377403 3.15204766681252e-37 yes 2 9.30069343660544e-35 33 3107280
SGTC_236 1509-0011 5.31 µM 11.9615578286064 1.24057676669614e-35 yes 3 2.82460252121837e-33 151 3107280
SGTC_134 0269-0018 6.916 µM 5.25676704081257 2.59892146832719e-08 yes 4 7.33049170305973e-08 95 4378915
SGTC_3342 9147791 14.508 µM 4.38945548648954 2.75833704931434e-06 yes 5 5.68174174812368e-06 9 1838168
SGTC_1989 st071868 50.2 µM 4.27401254229693 4.83819114685196e-06 yes 6 9.59931143766201e-06 7 16414057
SGTC_3064 1327-0027 10 µM 3.82713402035651 3.74106314014429e-05 yes 7 6.48219678477733e-05 10 16000455 YPR107C YTH1
SGTC_3045 9092950 49.47 µM 3.81248641000953 3.98658418836577e-05 yes 8 6.878789795208e-05 20 44120432
SGTC_2018 5133068 143 µM 3.80485898598326 4.12038931494732e-05 yes 9 7.09424994823305e-05 26 785362
SGTC_2852 9023854 51.95 µM 3.62503087061489 8.81984423697637e-05 yes 10 0.000144463468273918 39 19798528
SGTC_740 k014-0057 261 µM 3.61929564877603 9.03162110360622e-05 yes 11 0.000147702992412153 37 4012779
SGTC_1060 3448-7350 82 µM 3.43774778632288 0.000188116944033914 yes 12 0.000293286885629404 48 570178
SGTC_3336 9143619 71.43 µM 3.29088332109445 0.000332316555596445 yes 13 0.000499366644066284 43 45595730
SGTC_1312 1218-2183 165 µM 3.26362260252136 0.000368448480263688 yes 14 0.000549987902721344 17 6744073
SGTC_1319 1306-0155 43.7 µM 3.26353060542481 0.000368576368508261 yes 15 0.000550166495394075 63 3122360
SGTC_3048 9093155 49.47 µM 3.25882119424673 0.000375178426493344 yes 16 0.000559380774982037 16 25236002
SGTC_929 2805-0021 398 µM 3.21660206615041 0.00043946526461084 yes 17 0.000648591917420843 34 3098024
SGTC_621 3584-0052 32.1 µM 3.19999687817333 0.000467439150179201 yes 18 0.000687145380663164 46 2273927
SGTC_1214 0358-0031 63.7 µM 3.15549213803947 0.000550754612797625 yes 19 0.00080113792244408 47 4301366
SGTC_604 1000-0114 314 µM 3.13508128532881 0.000593385057199992 yes 20 0.000859032493094827 59 1572745
SGTC_2621 lithochol-11-enic acid 100 µM 3.03352846772589 0.000854518885176083 yes 21 0.00120855952381658 75 6708711
SGTC_3061 glucosamine 200 µM 2.98757725778121 0.00100440128170304 no 22 0.00140599106443598 42 91431 and experimental redox chemotherapeutic
SGTC_2941 9056145 11.23 µM 2.9706764411589 0.00106534361007078 no 23 0.00148572330426294 44 2119517
SGTC_421 streptovitacin 30 mM 2.96912672885704 0.00107109808236071 no 24 0.00149323701250644 79 91467 include heat shock
SGTC_1350 1495-0454 146 µM 2.89280261892357 0.00139238119851968 no 25 0.00190910581045018 81 1069057
SGTC_852 0418-0143 439 µM 2.85362849344468 0.00158945880575208 no 26 0.00216115222040835 142 5369229
SGTC_2854 9024559 71.43 µM 2.85134383136504 0.00160170166496357 no 27 0.00217674328194452 83 3163529
SGTC_841 0251-0215 91.2 µM 2.82464724950443 0.00175126829613388 no 28 0.00236663469629199 136 3888614
SGTC_2629 bisabolol 100 µM 2.80069914315456 0.00189613452056707 no 29 0.00254960171027035 93 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1630 st005209 31.3 µM 2.77503064681725 0.00206342775417921 no 30 0.00275982531093408 105 3367314
SGTC_3194 9111903 49.47 µM 2.7437139990211 0.00228561516075798 no 31 0.00303742192248894 86 17087251
SGTC_3215 9129942 49.47 µM 2.74071277120924 0.00230800756874067 no 32 0.00306530370568361 52 17682944
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.73944533686661 0.00231752352104437 no 33 0.00307714739554553 109 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1202 1988-0068 29.6 µM 2.73583932561076 0.00234479225619471 no 34 0.00311106993736829 98 2850480
SGTC_3034 9090421 49.47 µM 2.66779632515773 0.00291683546399937 no 35 0.00381752636881033 54 17173761
SGTC_2690 usnic acid 100 µM 2.65495781421353 0.00303792088459021 no 36 0.00396591636084854 107 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_291 SEC14.278 35.5 µM 2.65451052378224 0.00304221992720012 no 37 0.00397117810669285 62 1068044
SGTC_1262 0737-0114 49.6 µM 2.63774387794287 0.00320737474650528 no 38 0.0041729794999011 108 765919
SGTC_3039 9090270 49.47 µM 2.63269410369624 0.00325867314380433 no 39 0.00423553017536128 59 17173750
SGTC_2123 5259487 200 µM 2.6163484510784 0.00342982045226343 no 40 0.00444379038230626 98 2173474
SGTC_690 glyoxal 20.3 µM 2.60418333790521 0.00356239201896428 no 41 0.00460467393885255 185 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_534 k292-0788 63.4 µM 2.59739961043211 0.00363830036920307 no 42 0.00469662866766275 106 4146317
SGTC_1779 st039427 55 µM 2.59565710688563 0.0036580314198225 no 43 0.00472051151728897 138 1124498
SGTC_2027 5150920 200 µM 2.57134093832006 0.00394356784863331 no 44 0.00506527700448956 75 786715
SGTC_2125 5246583 200 µM 2.49291702691659 0.00500537906303566 no 45 0.00633492248214163 164 835267
SGTC_737 1950-0117 57.9 µM 2.47628579899898 0.00526087139406581 no 46 0.00663786297792093 119 5393513
SGTC_1881 5652484 16 µM 2.44769111319397 0.00572736191428554 no 47 0.00718874269117566 134 2255129
SGTC_1112 tnp00069 1.16933 µM 2.44429867806966 0.00578507322099765 no 48 0.00725670284836341 128 145826
SGTC_2876 9059903 25.97 µM 2.43774781414348 0.00589797701736974 no 49 0.00738954017958602 103 6916095
SGTC_794 k038-0031 316 µM 2.42689442822549 0.00608933976783699 no 50 0.00761434328997189 220 6624242
SGTC_3296 9122258 64.045 µM 2.4187745965627 0.00623608297897823 no 51 0.00778644334280821 130 4730474
SGTC_2525 harmine 47.85 µM 2.40957576020093 0.00640610220317866 no 52 0.00798553988955705 83 5280953 A monoamine oxidase inhibitor
SGTC_932 2857-0803 154 µM 2.39823745285337 0.00662129953260004 no 53 0.00823709092168302 124 674898
SGTC_2884 9058502 51.95 µM 2.35370459954976 0.00752961879845507 no 54 0.00929368782661114 150 6471554
SGTC_495 decylubiquinone 155 µM 2.34398507276555 0.00774187280056775 no 55 0.00953946748234789 157 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2456 5770359 74.46 µM 2.33363568385866 0.00797365330581775 no 56 0.00980740322277807 125 3118787
SGTC_2074 5212007 75.395 µM 2.29725121238247 0.00883763993433912 no 57 0.010802221592809 116 758611
SGTC_2060 5238662 140 µM 2.29237612140147 0.00895942476089787 no 58 0.0109419743518601 150 790130
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.28008039656378 0.00927313651953163 no 59 0.0113014603303303 245 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2253 7938677 135.83 µM 2.27508705212104 0.00940325529487009 no 60 0.0114503541153599 121 2301972
SGTC_1546 5-methoxyflavanone 78.7 µM 2.26794018320442 0.0095922692608509 no 61 0.0116664263752247 118 147795
SGTC_1113 artemisinin 1.17947 µM 2.25046984914889 0.0100683507755767 no 62 0.0122095676870527 139 2240 An anti-malaria and mitochondrial poison.
SGTC_2316 5844804 197.44 µM 2.24941951578127 0.0100976192251223 no 63 0.0122429090581837 214 776813
SGTC_514 4466-0038 2.65 nM 2.23575518066327 0.0104852067691972 no 64 0.0126839061348591 338 5722064
SGTC_2001 4023502 57.655 µM 2.23496106038217 0.0105081252650954 no 65 0.012709952638596 173 108941 YCR052W RSC6
SGTC_450 aminopyrene 156 nM 2.21845047766451 0.010994611250371 no 66 0.013262066317203 191 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1434 4073-0095 163 µM 2.2098427650098 0.0112559231804691 no 67 0.0135580382962895 134 24133745
SGTC_430 0958-0115 16.4 µM 2.20249022849876 0.0114833890811316 no 68 0.0138153493060702 178 6833180
SGTC_933 2914-0560 114 µM 2.19456387987157 0.0117330691594468 no 69 0.0140974484705323 192 463887
SGTC_545 4218-0007 221 µM 2.18046919303489 0.0121887024198702 no 70 0.0146113500076812 180 2840508
SGTC_1555 citronellol 128 µM 2.17599845941448 0.0123363938502004 no 71 0.014777687877405 102 8842 A terpine precursor.
SGTC_289 k017-0060 526 µM 2.17333778656414 0.0124250234588934 no 72 0.0148774517545409 130 5512909
SGTC_1384 3089-0840 101 µM 2.15340504371561 0.0131067158650316 no 73 0.0156434297762419 146 1069836
SGTC_2003 4023581 200 µM 2.15198037853721 0.0131566535497716 no 74 0.0156994498968303 192 16641307
SGTC_2976 9009005 19.48 µM 2.15150864878887 0.0131732249208742 no 75 0.015718036954772 171 2993148
SGTC_2761 levamisole 97.89 µM 2.14407235900265 0.0134368468456014 no 76 0.0160135447114874 161 26879 An alkaline phosphatase inhibitor.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.14382703397285 0.0134456208619939 no 77 0.0160233741843646 217 23847180
SGTC_2297 7971671 152.32 µM 2.14152171505949 0.0135283122062882 no 78 0.0161159946221247 177 909016
SGTC_2949 9072542 2.23 µM 2.13449094424724 0.0137832210584257 no 79 0.0164013070774019 231 16457352
SGTC_3021 9087658 49.47 µM 2.11084927344639 0.0146709935946881 no 80 0.0173926346795687 119 25237042
SGTC_1008 4106-0037 6 µM 2.1105086185481 0.0146841369962344 no 81 0.01740728480084 159 2905394
SGTC_597 k018-0003 82.8 µM 2.08238430703882 0.0158047693350872 no 82 0.0186536903487308 174 6786234
SGTC_778 3456-2434 196 µM 2.0705002059482 0.0162999017721191 no 83 0.0192027633889724 287 5539063
SGTC_3226 9131256 49.47 µM 2.06613997231258 0.0164848661173643 no 84 0.0194076324378226 70 17178073
SGTC_846 0335-0850 148 µM 2.05689158876327 0.016883143770802 no 85 0.0198483276271523 181 6819598
SGTC_1673 st016611 27.3 µM 2.05508850047301 0.0169617441039738 no 86 0.0199352287160535 257 5226799
SGTC_2364 9055074 200 µM 2.04908695402739 0.0172256214470214 no 87 0.0202268064740901 198 6470630
SGTC_684 1140-0066 328 µM 2.04786126051861 0.0172799421685164 no 88 0.0202867978414896 247 6813534
SGTC_2318 6029776 164 µM 2.04278290777358 0.0175065682511262 no 89 0.0205369666436771 230 818325
SGTC_1330 1469-0054 61.8 µM 2.04112774574503 0.0175809775304586 no 90 0.0206190655943935 184 7102664
SGTC_2709 st078560 56 µM 2.02549388974767 0.0182972258606302 no 91 0.0214083376275878 192 17250903
SGTC_2758 dehydroepiandrosterone 69.35 µM 2.01691527527521 0.0187007049690232 no 92 0.0218521778512898 234 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1883 5-benzylidenerhodanine 20 µM 2.00793041582235 0.0191313852899583 no 93 0.0223253432594009 307 1273210
SGTC_3294 9122953 26.2835 µM 2.00536075840846 0.0192560992264476 no 94 0.0224622468432278 212 16459826
SGTC_3025 9087895 49.47 µM 1.99657675487592 0.0196876465841816 no 95 0.0229355900435262 217 17173641
SGTC_1988 st071872 53.4 µM 1.99120875548405 0.0199553908482706 no 96 0.0232289708497805 175 16414116
SGTC_58 0957-0393 9 µM 1.98507166118395 0.0202652746788281 no 97 0.0235682495942709 672 6997992
SGTC_1751 st044839 27.194 µM 1.95057552477298 0.0220840098617867 no 98 0.0255537805326452 183 5291326
SGTC_286 k060-0067 22.9 µM 1.94568810964354 0.0223525076967493 no 99 0.0258461079012224 237 5985051
SGTC_206 4546-0025 72.014 µM 1.93903056404966 0.0227226763035911 no 100 0.0262488082995186 296 6620745 YIL048W NEO1
SGTC_365 0121-0052 13.6 µM 1.93756657548774 0.0228047653664419 no 101 0.0263380618250666 345 3101739
SGTC_716 1683-5115 658 µM 1.93599832607924 0.0228929776400109 no 102 0.0264339529917217 267 723597
SGTC_3257 9139206 32.98 µM 1.9299099292119 0.0232381722074092 no 103 0.0268089994657999 152 4910041
SGTC_2872 9044037 25.97 µM 1.92624549979883 0.0234480392935797 no 104 0.0270368634903423 157 6465195
SGTC_2616 abietic acid 100 µM 1.90898304388424 0.0244582544798524 no 105 0.02813213953241 262 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3315 9136395 68.55 µM 1.90242322825236 0.0248516033266333 no 106 0.0285579233472561 236 16876844
SGTC_1345 1488-0192 31.4 µM 1.89708016114962 0.0251758998125522 no 107 0.0289086795666133 243 658348
SGTC_1749 st037932 54.2 µM 1.89704693796797 0.0251779273293002 no 108 0.0289108717198764 260 594497
SGTC_2250 alverine citrate 130 µM 1.88860779699279 0.0256973948226903 no 109 0.0294722007341271 465 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1369 1866-0067 208 µM 1.8866054492757 0.025821956659854 no 110 0.0296067066446893 306 3531355
SGTC_353 1988-1175 58.3 µM 1.88570171739978 0.0258783411808671 no 111 0.0296675806720015 230 2788357
SGTC_32 0928-0142 34.1 µM 1.88345821139278 0.0260187606760281 no 112 0.0298191489621969 198 2244242
SGTC_713 1488-1073 324 µM 1.87626432172778 0.0264733262671423 no 113 0.0303094968071725 210 3312542
SGTC_287 k060-0039 29.6 µM 1.87335240713813 0.0266592009123942 no 114 0.030509868725653 239 5861974
SGTC_3262 9137218 49.47 µM 1.86489435977305 0.0272052900575992 no 115 0.0310981065953736 121 17650664
SGTC_2702 st077768 96.8 µM 1.86285686436853 0.0273382255878856 no 116 0.0312412035401074 249 6484119
SGTC_1691 st019933 84.6 µM 1.86085905630527 0.0274690973319824 no 117 0.0313820415318299 227 6176082
SGTC_1064 honokiol 6.76 µM 1.86001260839996 0.0275247034917856 no 118 0.031441871068037 269 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1043 0916-0009 19.3 µM 1.85324867635386 0.0279724297961837 no 119 0.0319233618680151 328 3101130
SGTC_71 0417-1750 47.813 µM 1.85313272919338 0.0279801572782264 no 120 0.0319316683664464 306 6811472
SGTC_1151 3909-8316 15.3 µM 1.84970625173434 0.0282093241588299 no 121 0.0321779494801644 276 800431
SGTC_41 0478-0632 82.643 µM 1.84731606325612 0.0283701061745202 no 122 0.0323506731089176 311 3750424
SGTC_312 4092-0653 6.84 µM 1.84566955928799 0.0284813053943756 no 123 0.0324700998812584 388 1148278
SGTC_2124 5246320 200 µM 1.84515158144827 0.0285163627287793 no 124 0.0325077457743836 271 579342
SGTC_2875 9039966 71.43 µM 1.83320365273781 0.0293350283850486 no 125 0.0333861454463794 210 6463691
SGTC_844 0330-0132 15.3 µM 1.83244293525077 0.0293878065657056 no 126 0.0334427281280029 262 2828079
SGTC_2030 5175110 200 µM 1.83128906116731 0.0294680122253957 no 127 0.0335287047487726 252 2831986
SGTC_888 0916-0002 6.97 µM 1.83022849448716 0.0295418922951735 no 128 0.0336078893122226 256 2802138 YIL048W NEO1
SGTC_2889 9059656 51.95 µM 1.82098795953516 0.0301921244764194 no 129 0.0343043435761544 270 3949838
SGTC_2766 oltipraz 83.91 µM 1.81905533230493 0.0303296077342057 no 130 0.034451494396018 259 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1243 0416-0003 5.65 µM 1.81892274044167 0.0303390590421003 no 131 0.0344616089626345 313 2141977
SGTC_643 k048-0106 28.4 µM 1.81234763008178 0.0308108111272024 no 132 0.0349662496582972 250 6763920
SGTC_1875 nocodazole 6 µM 1.80687699335645 0.0312079326650141 no 133 0.0353907302293847 274 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_513 4245-1575 41.7 µM 1.80596684995324 0.031274410310763 no 134 0.0354617589022311 450 719745
SGTC_3234 9132280 49.47 µM 1.80171892698358 0.0315862328916105 no 135 0.035794819353115 285 17612295
SGTC_2799 7812892 81.82 µM 1.80155298010389 0.0315984663351242 no 136 0.0358078823445406 295 20205235
SGTC_705 1124-0212 310 µM 1.79998152626751 0.0317145066185324 no 137 0.0359317776412803 302 9554485
SGTC_2898 9056270 58.44 µM 1.79813629804215 0.031851212354191 no 138 0.0360777056702066 210 19154699
SGTC_3264 9137442 49.47 µM 1.79716875190117 0.0319230883674864 no 139 0.0361544168431346 231 17015726
SGTC_63 0099-0242 26.702 µM 1.7800903053016 0.033213997428669 no 140 0.0375305914604104 373 3898502 YLR359W ADE13
SGTC_777 1315-0167 517 µM 1.76040309066546 0.0347551341663273 no 141 0.0391697428473298 280 4221767
SGTC_1168 k815-0004 80.5 µM 1.75708075378593 0.0350209123580775 no 142 0.0394520228649786 274 642433
SGTC_1302 1159-0335 255 µM 1.75652470188698 0.0350655575711224 no 143 0.0394994286948756 279 649284
SGTC_179 1273-0063 6.77 µM 1.75597312331267 0.0351098897542372 no 144 0.0395464989216902 269 3108139
SGTC_1851 st056236 18.9 µM 1.75420731421702 0.0352521230093394 no 145 0.0396974951977319 300 5393171
SGTC_2835 9006588 71.43 µM 1.75307742759842 0.035343381400255 no 146 0.0397943587551585 336 2345538
SGTC_1404 3909-7820 48.3 µM 1.75263457431995 0.0353792024723171 no 147 0.0398323763060643 272 23741373
SGTC_1176 0848-0131 83.3 µM 1.7520833766347 0.0354238287832723 no 148 0.0398797361181956 327 6769040
SGTC_3168 9103419 49.47 µM 1.74906712078186 0.0356688503190305 no 149 0.0401397089041368 175 16649256
SGTC_962 1254-0300 21.5 µM 1.74303374966002 0.0361631316157792 no 150 0.0406638598485986 287 7340576
SGTC_396 dithiazanine 1.25 µM 1.73665255461621 0.0366919965630423 no 151 0.0412242585396439 253 10578 An antihelmenthic.
SGTC_2568 diosmetin 100 µM 1.73570052330116 0.0367714392804848 no 152 0.0413084004669515 325 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3231 9132313 49.47 µM 1.73493767845879 0.0368351967058502 no 153 0.0413759222314668 285 4905967
SGTC_857 0438-0306 1.35 µM 1.73482517491344 0.0368446072273116 no 154 0.0413858878340406 301 4686136
SGTC_283 0987-0079 11.7 µM 1.72338277687371 0.0378120398530337 no 155 0.0424096637031776 348 411556
SGTC_2674 ligustilide 100 µM 1.72187608121029 0.0379409588649286 no 156 0.0425459843499518 254 5319022 A signalling regulator.
SGTC_779 1360-0071 233 µM 1.71904737597577 0.0381839630127082 no 157 0.0428028728688341 321 7566
SGTC_1509 1326-1131 80 µM 1.71168224760693 0.0388226344301758 no 158 0.0434776209423213 282 768313
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.71104542522018 0.0388782631431459 no 159 0.0435363637779054 335 140250 A respiratory chain inhibitor.
SGTC_1450 4112-4260 37.6 µM 1.70678069742685 0.0392524775105664 no 160 0.0439314107328264 329 1633175
SGTC_1200 1643-0193 18.4 µM 1.69620080957255 0.0401934905211917 no 161 0.0449239286040032 327 5403974
SGTC_945 3381-0768 11.3 µM 1.69369699623831 0.0404188494638612 no 162 0.0451614377771936 341 1126236 YIL048W NEO1
SGTC_84 0443-0269 128.823 µM 1.69288735890962 0.0404919410505682 no 163 0.0452384549733418 342 6150058
SGTC_1118 chelidonine 707.474 nM 1.69122369302346 0.0406424685226415 no 164 0.0453970437500337 341 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1019 4262-0212 3.4 µM 1.68437300198191 0.0412671071769986 no 165 0.0460548025239176 399 4677213
SGTC_1828 st055811 49 µM 1.67681763704313 0.0419649978043347 no 166 0.0467890738907781 279 5877589
SGTC_27 0485-0001 32.618 µM 1.67593675714153 0.0420469831523394 no 167 0.0468752904764158 220 2054479
SGTC_188 3229-0966 278.469 µM 1.67145462560913 0.0424661548291556 no 168 0.047315956971174 403 5722370
SGTC_395 anisomycin 6.25 µM 1.66364290109824 0.0432047854828508 no 169 0.0480919065807078 269 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2677 mitomycin C 100 µM 1.66188272920491 0.0433726411891798 no 170 0.04826814510952 271 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1482 3346-2049 8.48 µM 1.65960910202277 0.0435902405411666 no 171 0.0484965580333042 323 3826804
SGTC_2097 5376186 200 µM 1.65626329184518 0.0439120553803106 no 172 0.0488342554287434 370 742755
SGTC_2584 androsterone 48.74 µM 1.65372495747485 0.0441574797580619 no 173 0.0490917046605216 514 2754130 A steroid.
SGTC_1322 1348-1070 12 µM 1.65262104261629 0.0442645586325971 no 174 0.0492040063800721 266 6758089
SGTC_489 paxilline 115 µM 1.65135002450313 0.0443881054927202 no 175 0.04933356157472 319 105008 A toxic potassium channel blocker.
SGTC_2179 6298986 200 µM 1.64430132494725 0.0450783126868624 no 176 0.0500569878995683 302 738374
SGTC_371 0195-0006 7.36 µM 1.63644703831064 0.0458575492885246 no 177 0.0508730307081691 293 3928593
SGTC_773 4358-1457 44.6 µM 1.63100197924109 0.0464040885012949 no 178 0.0514449509401636 411 1186886
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.62972600828825 0.0465329153652577 no 179 0.0515797089840114 376 688801
SGTC_3170 9103054 49.47 µM 1.62934198358148 0.0465717441005444 no 180 0.0516203215630062 311 16432970
SGTC_3160 9100216 49.47 µM 1.62543253501518 0.0469685098343412 no 181 0.052035214076088 319 17191039
SGTC_3318 9139014 38.6185 µM 1.62184886742724 0.0473345893663054 no 182 0.0524178560660275 328 16643984
SGTC_984 1492-0255 2.91 µM 1.61920586498045 0.0476060401401737 no 183 0.0527014882602804 334 1585198
SGTC_738 1315-0003 72.4 µM 1.61679273386873 0.0478549694518629 no 184 0.0529615141995876 372 6251474
SGTC_2625 euphol 100 µM 1.61543505428418 0.0479954798764039 no 185 0.0531082570686306 405 6708538 A triterpene alcohol.
SGTC_1753 st043925 64 µM 1.6142243039164 0.0481210625076101 no 186 0.0532393910689752 371 670181
SGTC_3176 9106582 49.47 µM 1.6138427852066 0.0481606892001754 no 187 0.0532807657542616 191 17018027
SGTC_3297 9117502 71.43 µM 1.6136348899627 0.0481822933646886 no 188 0.0533033221639615 303 7453720
SGTC_458 nppb 133 µM 1.60696980296981 0.0488790379198382 no 189 0.0540304962280118 313 4549 A chloride channel blocker.
SGTC_1557 sumaresinolic acid 42.3 µM 1.60481681407027 0.0491058163186109 no 190 0.0542670622789553 345 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2819 7996655 46.38 µM 1.60300534687581 0.049297271910439 no 191 0.0544667368118232 327 6456960
SGTC_747 3448-8087 38.7 µM 1.59973607593375 0.0496443121864633 no 192 0.0548285725588421 403 5168703
SGTC_675 1309-0189 238 µM 1.59828302871709 0.049799180804178 no 193 0.0549900013281676 353 4246530
SGTC_1720 st037298 9.481 µM 1.5978408476701 0.0498463857354901 no 194 0.0550392006533249 356 597396
SGTC_3067 9117431 49.47 µM 1.59755428643178 0.0498769965669403 no 195 0.0550711034914052 319 17150885
SGTC_81 0411-0046 9.971 µM 1.59659825321354 0.0499792297017456 no 196 0.0551776442774721 336 12925265
SGTC_1837 st055472 66.5 µM 1.59562370520716 0.050083614629964 no 197 0.0552864158675118 368 676091
SGTC_500 h-89 112 µM 1.59468035192087 0.050184823751113 no 198 0.0553918669719291 386 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1435 4092-0789 56.7 µM 1.59376084719603 0.050283631082606 no 199 0.0554948049902882 354 2248285
SGTC_314 1671-0008 2.74 µM 1.59376021993885 0.0502836985387385 no 200 0.055494875262874 436 3913060
SGTC_1882 5615643 20 µM 1.5913414840032 0.0505443496684515 no 201 0.0557663728019766 326 2253075
SGTC_442 cape 100 µM 1.58636677468669 0.0510838240090079 no 202 0.0563280664189007 331 5281787
SGTC_3347 9188721 44.724 µM 1.58499280848704 0.051233626360177 no 203 0.0564839841116917 329 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3139 9095020 49.47 µM 1.58442522738782 0.0512956111603419 no 204 0.0565484924051688 256 25236292
SGTC_2458 5808907 16.39 µM 1.58051165613118 0.0517246325990848 no 205 0.0569948698322149 355 2731747
SGTC_1895 st058434 18.3 µM 1.57710922413243 0.0520999343209929 no 206 0.0573851975672595 379 5393175
SGTC_1204 4049-0315 18.3 µM 1.57514144886017 0.0523179730314131 no 207 0.0576118992654145 390 588402
SGTC_1143 3454-2408 5.08 µM 1.57353481366553 0.0524965324952065 no 208 0.0577975168721684 299 X1143
SGTC_1059 3448-6867 171 µM 1.56420886769307 0.0535425791256021 no 209 0.0588842626888237 377 3934407
SGTC_1841 st054148 70 µM 1.55967098404979 0.0540575100513103 no 210 0.059418826207256 362 675442
SGTC_2048 5246248 200 µM 1.55732328239116 0.0543254470219111 no 211 0.0596968751771242 328 677046
SGTC_2188 6126565 140.678 µM 1.55172431012354 0.0549686839247827 no 212 0.060364101655945 307 874518
SGTC_2104 5389443 200 µM 1.54150171394174 0.0561586163688601 no 213 0.0615973630565331 442 2244536
SGTC_69 0096-0274 206.684 µM 1.5399807672213 0.0563373808215021 no 214 0.0617825207902234 472 6741392
SGTC_3055 9094636 49.47 µM 1.53910633810377 0.0564403597333683 no 215 0.061889168990689 363 25236176
SGTC_3221 9128209 49.47 µM 1.5358937640746 0.0568199692130544 no 216 0.0622822189091534 360 16460723
SGTC_195 4234-0266 16.654 µM 1.53465326028499 0.0569670887064993 no 217 0.0624345112598257 455 2303354
SGTC_502 l-744,832 89.3 µM 1.5342529766475 0.0570146249250608 no 218 0.06248371460827 419 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1913 st060213 96.1 µM 1.5273729488332 0.0578365627286772 no 219 0.0633341495600432 444 688959
SGTC_1044 1222-0021 1.78 µM 1.52683575514015 0.0579011298234038 no 220 0.0634009290739888 422 4306703
SGTC_3123 9126162 49.47 µM 1.5262985546527 0.0579657543819672 no 221 0.06346776422906 381 25239884
SGTC_1967 st070177 51.4 µM 1.52609212921138 0.0579906021811053 no 222 0.0634934609821884 357 5729214
SGTC_1783 st039459 87.517 µM 1.52460437607181 0.0581699333480016 no 223 0.063678902626018 453 729761
SGTC_732 3970-1727 52.7 µM 1.52439323357424 0.0581954193642713 no 224 0.0637052546851089 369 1275699
SGTC_2879 9041815 71.43 µM 1.52344151466401 0.0583104057758734 no 225 0.0638241411741112 277 4942971
SGTC_1912 st060209 90.8 µM 1.5201442223308 0.0587101643532195 no 226 0.0642373661585504 414 688787
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.5198037818126 0.0587515610523802 no 227 0.0642801491834927 466 6728940
SGTC_2264 7948757 110.76 µM 1.5183161908051 0.0589327171448683 no 228 0.0644673539982206 380 2971411
SGTC_1144 3486-0183 12.5 µM 1.51815180128965 0.0589527630597918 no 229 0.0644880674418646 437 6744069
SGTC_3086 9117350 49.47 µM 1.51531790600311 0.0592991743701542 no 230 0.06484595793854 292 2679265
SGTC_2272 7805186 180 µM 1.51366920978922 0.0595014418091925 no 231 0.0650548789669377 375 2956062 YPR165W RHO1
SGTC_1689 st020265 53.493 µM 1.51020725822646 0.059927924997604 no 232 0.065495273610352 386 5758320 YPR016C TIF6
SGTC_731 3966-0296 387 µM 1.5096849839119 0.0599924721049366 no 233 0.0655619123306024 402 660956
SGTC_1763 st044482 94.5 µM 1.49755743602042 0.0615066603755413 no 234 0.067124136213769 431 88505
SGTC_536 3852-0578 10.6 µM 1.48446349670631 0.0631748447361323 no 235 0.0688430001567231 405 2869208
SGTC_612 0302-0167 22.4 µM 1.48412141574251 0.0632188939043324 no 236 0.0688883563562023 498 235821
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.48364129093042 0.0632807590713332 no 237 0.0689520545137488 383 364106
SGTC_3089 9117425 49.47 µM 1.48354474095939 0.0632932054435871 no 238 0.0689648692792076 412 9401657
SGTC_1588 farnesol 29.9 µM 1.47944727711306 0.0638231731839334 no 239 0.0695104062501962 433 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1221 2958-7315 257 µM 1.47543903912255 0.064344933758847 no 240 0.0700472731128444 438 4562705
SGTC_1876 myriocin 605 nM 1.47373275577997 0.0645680474939138 no 241 0.0702767799051032 432 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2899 9053889 58.44 µM 1.47292387569926 0.0646740264642865 no 242 0.0703857816630763 383 6470052
SGTC_2523 spermine 47.74 µM 1.47105283414801 0.0649196868147399 no 243 0.0706384145291377 414 1103 A DNA binding polyamine.
SGTC_2484 5809818 12.04 µM 1.47088245996087 0.0649420922066031 no 244 0.0706614534656831 426 2870548
SGTC_1372 2752-0194 270 µM 1.4708788846349 0.0649425624511583 no 245 0.0706619370028204 416 823334
SGTC_220 paclitaxel 373.376 µM 1.47015319998721 0.0650380628115857 no 246 0.070760133282336 360 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_223 busulfan 5 mM 1.46088466193485 0.0662674131092325 no 247 0.0720235482748996 348 2478 A DNA alkylator.
SGTC_2480 5767542 37.17 µM 1.46076534499846 0.066283355459149 no 248 0.0720399246524936 420 2867358
SGTC_1498 4478-3555 97.6 µM 1.45829385002356 0.0666142488619736 no 249 0.0723797823288332 359 3437919
SGTC_503 tyrphostin 8 294 µM 1.45686319724302 0.0668063736548163 no 250 0.0725770733878675 450 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_916 4466-0038 42 nM 1.45534583988369 0.0670106103535664 no 251 0.0727867710755675 581 5722064 YGL116W CDC20
SGTC_2145 5634607 200 µM 1.45522388877186 0.0670270459485527 no 252 0.0728036447501611 386 308662
SGTC_2788 5282734 71.43 µM 1.45389195944688 0.0672067557640792 no 253 0.0729881311896997 504 743706
SGTC_2023 5144124 124 µM 1.45130235807159 0.0675572222874887 no 254 0.0733478424870226 441 2830192
SGTC_647 0140-0236 81 µM 1.44872608927091 0.0679072840707872 no 255 0.0737070458063052 511 990837
SGTC_2117 5521686 200 µM 1.44822463019971 0.0679755845867871 no 256 0.0737771191903014 428 803312
SGTC_2589 lobaric acid 100 µM 1.44614135446771 0.0682599022241317 no 257 0.0740687793136136 448 73157 A novel microtubule depolymerizer.
SGTC_118 0083-0097 135.343 µM 1.44454078122323 0.0684789651879879 no 258 0.0742934584454601 689 5207356
SGTC_707 0865-0008 204 µM 1.44352032887162 0.0686189125845335 no 259 0.0744369750417156 444 723043
SGTC_989 1501-0895 10.3 µM 1.44309774877972 0.0686769308248123 no 260 0.0744964687152381 416 2830112
SGTC_591 4299-0174 154 µM 1.44257792177651 0.0687483524867994 no 261 0.0745697032458647 418 5509088
SGTC_1853 st056710 91.2 µM 1.43777166498097 0.069411423856602 no 262 0.0752494257481659 455 269167
SGTC_2764 methyldopa 94.69 µM 1.43679385437318 0.069546923649351 no 263 0.0753882885824689 469 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2780 5215298 71.43 µM 1.43494448907355 0.0698037556410063 no 264 0.0756514583313199 489 2834131
SGTC_2909 7941780 10.49 µM 1.43457367765751 0.0698553401025253 no 265 0.0757043099468474 460 1243215
SGTC_861 0443-0273 110 µM 1.4247288170895 0.0712356374078903 no 266 0.0771178028638223 459 6149169
SGTC_2469 5655019 90.81 µM 1.42116973467244 0.0717397590324647 no 267 0.0776337104894797 470 2788239
SGTC_78 0336-0123 156.75 µM 1.41846480946582 0.0721247214514302 no 268 0.0780275528678329 416 6765896
SGTC_2054 5233173 129 µM 1.41792391019305 0.0722018913634246 no 269 0.07810649040985 528 6889
SGTC_1394 3474-0001 65.7 µM 1.41631572004549 0.0724317050902532 no 270 0.0783415436362833 415 5017666 YIL048W NEO1
SGTC_934 2950-0684 338 µM 1.41612759616475 0.0724586249564806 no 271 0.0783690748460496 500 1121253
SGTC_830 4076-0286 57.8 µM 1.41276382040328 0.0729412642366503 no 272 0.0788625897052704 635 6866659
SGTC_837 0091-0265 12.5 µM 1.40566601139885 0.0739677376197929 no 273 0.0799116621021605 507 759367
SGTC_2395 5646831 180.19 µM 1.40428295192429 0.0741690321116013 no 274 0.0801173043981305 471 6808628
SGTC_1679 SEC14.276 6.7 µM 1.39916043494324 0.0749182240327645 no 275 0.0808824390729529 562 1005053 YMR079W SEC14
SGTC_3349 9149703 23.001 µM 1.39790987533849 0.0751019978956417 no 276 0.0810700663925697 450 4910494
SGTC_2608 thymoquinone 42.66 µM 1.39787603369083 0.0751069758104105 no 277 0.0810751483745236 423 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2954 9074818 52.69 µM 1.39459387523009 0.0755909592439249 no 278 0.0815691715456439 474 16648742
SGTC_3247 9135149 49.47 µM 1.39444958371438 0.075612290711823 no 279 0.0815909419556476 419 8934436 YOR116C RPO31
SGTC_2047 4141938 200 µM 1.39444665234693 0.0756127241207333 no 280 0.0815913842797998 412 3807862
SGTC_3144 9087057 49.47 µM 1.39302882974457 0.0758225741402001 no 281 0.0818055364194723 475 17249618
SGTC_736 0958-0254 92.6 µM 1.38996168675607 0.0762780551531905 no 282 0.08227025596306 522 6812352
SGTC_3236 9132701 49.47 µM 1.38607908776346 0.0768576166860651 no 283 0.0828613775948033 481 24282524
SGTC_1424 4048-1941 275 µM 1.38573236392242 0.0769095350759145 no 284 0.0829143209592521 514 X1424
SGTC_3265 9137266 49.47 µM 1.38508227748088 0.0770069507963547 no 285 0.083013655177059 421 17224265
SGTC_1739 st037196 92.5 µM 1.38488248291466 0.0770369089265404 no 286 0.083044202071984 508 612214
SGTC_2287 7945887 168.79 µM 1.3836650910319 0.0772196417951081 no 287 0.0832305136854439 501 1245853
SGTC_1525 8-methoxypsoralen 92.5 µM 1.37122397750895 0.0791059979900827 no 288 0.0851525729141348 552 4114 Related to psoralen; DNA damaging agent.
SGTC_506 n9-isopropylolomoucine 153 µM 1.3689912982398 0.0794481853045867 no 289 0.0855009974923895 474 6610355
SGTC_2804 7954240 19.48 µM 1.36742216974924 0.0796893442799389 no 290 0.0857465086428114 537 828705
SGTC_1192 1488-0095 21.4 µM 1.36493939189397 0.0800720525325669 no 291 0.0861360500006858 476 915875
SGTC_1079 idarubicin 2.36 µM 1.35720050008592 0.0812738818277134 no 292 0.0873587559517783 485 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1861 st057647 17.4 µM 1.35679026136327 0.0813379685849607 no 293 0.0874239313768401 510 688668
SGTC_2917 7979103 53.79 µM 1.35351156983154 0.0818515303271212 no 294 0.0879461281818687 577 2980565
SGTC_743 1275-0778 158 µM 1.35156639315321 0.0821573682585102 no 295 0.0882570336293099 534 2849257 YMR203W TOM40
SGTC_1257 0669-0121 16 µM 1.34989289405586 0.0824211788128314 no 296 0.0885251706870381 581 4307855
SGTC_2086 5274770 176.623 µM 1.34764111774735 0.0827771548481528 no 297 0.0888869194970373 495 689278
SGTC_1710 st031758 61.5 µM 1.34665518821866 0.0829333809190474 no 298 0.0890456554751283 468 5394341
SGTC_639 0833-0042 114 µM 1.34406728861487 0.0833445031998778 no 299 0.0894633143973138 552 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2798 7813637 45.45 µM 1.34273000058687 0.0835575486641462 no 300 0.0896797083388694 514 956368
SGTC_275 trichlorophene 5.69 µM 1.33599727752955 0.0846363695229972 no 301 0.0907750815792767 696 62616
SGTC_1903 st060211 78.3 µM 1.33534101643864 0.0847420820361887 no 302 0.0908823800245455 543 688960
SGTC_1270 0831-1170 17.3 µM 1.33507493157135 0.0847849719881827 no 303 0.0909259116027312 572 6764716
SGTC_1233 0325-0408 14.2 µM 1.3307593475744 0.0854828712424758 no 304 0.0916341041063468 518 12874
SGTC_3178 9107506 49.47 µM 1.32815340662218 0.085906372029933 no 305 0.0920637166123922 524 8897194
SGTC_3354 9151612 71.43 µM 1.3264025360047 0.0861917929020944 no 306 0.0923531996190725 563 27261949
SGTC_2620 irigenin 100 µM 1.32532224379889 0.0863682519027016 no 307 0.0925321471804332 554 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1727 st034309 9.9045 µM 1.32317553139559 0.0867197055479753 no 308 0.0928885055531501 611 870305
SGTC_3207 9114163 49.47 µM 1.32039594417439 0.0871763581021153 no 309 0.0933514285158947 602 849233
SGTC_2891 9063876 19.48 µM 1.31537357045587 0.0880060228960617 no 310 0.0941921917384885 453 6472478
SGTC_1212 0520-0165 585 µM 1.30854904461702 0.0891428084453215 no 311 0.0953435755055048 539 5403258
SGTC_168 3970-0862 530.542 µM 1.30694694341528 0.0894112529813592 no 312 0.0956153657020891 723 3135186
SGTC_3256 9138902 49.47 µM 1.303865230905 0.0899293078859591 no 313 0.0961397684282436 505 17228773
SGTC_2180 6301957 200 µM 1.29771881711768 0.0909692136860635 no 314 0.0971919875665728 522 845462
SGTC_3353 9151644 39.2805 µM 1.29627230146283 0.0912152399001529 no 315 0.0974408438942843 561 4909158
SGTC_769 0302-0231 76 µM 1.29188780031769 0.0919639782995098 no 316 0.0981980015931141 644 571869 YER009W NTF2
SGTC_1569 carminic acid 40.6 µM 1.29041478199675 0.092216543308357 no 317 0.0984533412260911 582 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1247 0448-0043 5.84 µM 1.28867882086424 0.0925148513785611 no 318 0.0987548842119574 588 3089013 YGL099W LSG1
SGTC_618 k072-0232 33.2 µM 1.28724810435416 0.0927612423012296 no 319 0.0990039126841903 528 5872756 YGL099W LSG1
SGTC_2910 7948405 25.97 µM 1.28301217259344 0.093493578373526 no 320 0.0997439057493431 505 2971328
SGTC_3012 9080433 71.4286 µM 1.28286176554934 0.0935196600239276 no 321 0.0997702550854708 578 17688859
SGTC_1558 st069300 45.6 µM 1.28158694813575 0.0937409382421639 no 322 0.0999937905550583 464 24208000
SGTC_2716 st080858 38.6235 µM 1.28008927899254 0.0940013917632222 no 323 0.100256869370057 538 5296050
SGTC_1184 1269-1718 139 µM 1.27404312261709 0.0950582842598723 no 324 0.101324066970207 576 5403821
SGTC_413 propylparaben 100 µM 1.27147690359568 0.0955095059871166 no 325 0.101779519505679 548 7175 A pharmaceutical preservative.
SGTC_539 4859-0462 2.54 µM 1.2710482217116 0.0955850351018205 no 326 0.101855747009096 564 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_701 4424-0219 185 µM 1.26954339198792 0.0958505177895519 no 327 0.102123662295924 633 2911779
SGTC_1767 st044992 70.3 µM 1.26220551396248 0.097152842394071 no 328 0.103437422560677 576 9600693
SGTC_3103 9120822 49.47 µM 1.26134927472905 0.0973056495047892 no 329 0.103591517700673 606 17141819
SGTC_1333 1482-0047 286 µM 1.25892345710997 0.0977395257813716 no 330 0.104028990131976 618 3811116
SGTC_1216 1165-0504 9.65 µM 1.25850742747722 0.0978140781625981 no 331 0.10410415137246 595 6304004
SGTC_640 3381-0960 37.1 µM 1.25513125725053 0.0984206290690736 no 332 0.104715557596532 611 1745025
SGTC_1334 1486-0610 236 µM 1.25505594954264 0.0984341899196126 no 333 0.104729225004011 586 3742339
SGTC_1348 1493-0373 93.8 µM 1.25322231076298 0.098764800255062 no 334 0.1050624062899 572 3010129
SGTC_1225 1216-0074 20.6 µM 1.25292174181033 0.0988190711286758 no 335 0.105117094267909 582 4241466
SGTC_3266 9136860 49.47 µM 1.25266224761674 0.0988659430738974 no 336 0.105164325336286 581 4871271 YPR165W RHO1
SGTC_662 k832-1615 104 µM 1.25006241211463 0.0993364446110211 no 337 0.105638374595865 565 5878478
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.24777212769725 0.0997522799919405 no 338 0.106057259296333 614 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3027 9089541 49.47 µM 1.24615604775697 0.100046467783261 no 339 0.106353555758655 607 9943819
SGTC_1467 k284-1082 293 µM 1.24549475164883 0.100167031213779 no 340 0.106474971765627 612 3334705
SGTC_225 nsc-122657 1.016 µM 1.24503506066602 0.100250901707921 no 341 0.106559431391142 449 275685
SGTC_802 4112-3352 742 µM 1.24394525144536 0.100449941885955 no 342 0.106759856679904 647 704594
SGTC_2340 7987427 183.45 µM 1.2394189487844 0.101279701024472 no 343 0.107595193821694 583 2239331
SGTC_279 1273-0055 2.93 µM 1.23769198676347 0.101597599308539 no 344 0.107915145761475 645 2847562
SGTC_985 1493-0307 8.71 µM 1.23673753715314 0.101773605360192 no 345 0.108092269070897 541 3278274
SGTC_2831 7999036 19.48 µM 1.23639193107912 0.101837391834844 no 346 0.108156456983173 620 2988270
SGTC_1744 st037937 38.9 µM 1.23304115534206 0.102457334003045 no 347 0.108780204959348 589 1016152
SGTC_33 0986-0033 35.816 µM 1.23108175966761 0.102821119707733 no 348 0.10914614343042 554 2848082
SGTC_3232 9132874 49.47 µM 1.23100002934682 0.102836314303852 no 349 0.109161426653277 569 3784940
SGTC_3131 9127911 49.47 µM 1.23086585232262 0.102861262876425 no 350 0.109186520521414 582 45595681
SGTC_67 0335-0847 266 µM 1.23024002028175 0.10297768676509 no 351 0.109303618761395 754 4552207 YOR254C SEC63
SGTC_2439 5492030 7.2 µM 1.22942541285889 0.103129371998253 no 352 0.109456173509112 582 5722370
SGTC_729 4092-0585 94.1 µM 1.22907980164884 0.103193776069962 no 353 0.109520943666038 559 2169061
SGTC_83 0170-0301 39.027 µM 1.2284724600961 0.103307023903055 no 354 0.109634830743329 476 3089716
SGTC_2077 5212015 200 µM 1.22818226110793 0.103361167651068 no 355 0.109689278098244 572 780900
SGTC_98 0074-0023 107.663 µM 1.22526650603891 0.103906316987924 no 356 0.110237411879246 634 3563821
SGTC_620 0109-0052 432 µM 1.22486129049222 0.103982243566596 no 357 0.110313743694898 614 493037
SGTC_1101 ebselen 5.29 µM 1.22377962825366 0.104185115218748 no 358 0.110517685655023 639 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1891 st059073 26.2 µM 1.22108952078665 0.104690903322641 no 359 0.111026063466087 650 688754
SGTC_1301 naphtanilide LB 4.81 µM 1.21734498710592 0.105397899450764 no 360 0.111736492290121 638 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1022 4477-0945 21.3 µM 1.21674068535099 0.105512319059509 no 361 0.111851447032797 616 4648966
SGTC_1261 0712-0010 12.7 µM 1.21648402462741 0.105560942844078 no 362 0.111900296512522 641 2840123
SGTC_319 1348-1596 45.5 µM 1.2146438811421 0.105910028409538 no 363 0.112250972435678 637 5380505
SGTC_2645 abamectin 100 µM 1.21389571505321 0.106052198027752 no 364 0.112393774699642 596 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2281 7943571 200 µM 1.21126156456606 0.106553847506037 no 365 0.112897587180547 644 1244024
SGTC_3237 9133362 49.47 µM 1.20782884642055 0.107210144359575 no 366 0.113556551625903 601 43845137
SGTC_833 3852-0053 558 µM 1.20667366899264 0.107431655334359 no 367 0.11377892168368 686 3123681
SGTC_1688 st021091 57.6 µM 1.20563008477532 0.107632051208514 no 368 0.113980076882233 606 3656366
SGTC_2295 7971645 200 µM 1.20369594478105 0.108004169318346 no 369 0.114353560113291 621 2978226 YKL099C UTP11
SGTC_1134 3477-0009 42.5 µM 1.20347978350851 0.10804581506266 no 370 0.114395355014671 670 3973534
SGTC_3058 9093861 49.47 µM 1.20148788086794 0.108430120311946 no 371 0.114781002390925 603 17217477
SGTC_626 0214-0009 33 µM 1.20083804323839 0.10855570843852 no 372 0.11490701573099 646 3437874
SGTC_3230 9131665 49.47 µM 1.19778858286732 0.109146447178126 no 373 0.115499666528765 486 15943720
SGTC_318 1488-0629 67.2 µM 1.19653608375649 0.109389748245024 no 374 0.115743713031472 583 3662576
SGTC_760 0568-0725 82.9 µM 1.19590834603073 0.109511834303147 no 375 0.115866163930488 663 3916171
SGTC_416 estradiol valerate 100 µM 1.19270142144643 0.110137062427609 no 376 0.116493164378577 612 13791 A steroid.
SGTC_1798 st045719 60.953 µM 1.18494433559621 0.11165997607824 no 377 0.118019728157788 574 3980186
SGTC_2700 st077718 96.8 µM 1.18287648684553 0.112068478831577 no 378 0.118429050800457 579 904970
SGTC_2978 9011784 42.97 µM 1.18132175024392 0.112376319311713 no 379 0.118737465025529 743 2994934
SGTC_3313 9133968 57.047 µM 1.1800451525112 0.112629539177087 no 380 0.118991128525178 669 1494643
SGTC_1130 3454-2858 15.9 µM 1.17720388060815 0.113194582516031 no 381 0.119557070076279 620 715628 YIL048W NEO1
SGTC_2087 5276107 200 µM 1.175401274619 0.113554113462946 no 382 0.119917106898553 638 144405
SGTC_1596 piperlongumine 63 µM 1.17474969070123 0.113684272439721 no 383 0.12004743647867 712 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_516 3992-2719 87.3 µM 1.17451276875109 0.113731625805052 no 384 0.120094850261686 584 5350887 YDR037W KRS1
SGTC_1448 4255-0083 152 µM 1.17422365209262 0.113789430321293 no 385 0.120152727338167 662 5399660
SGTC_823 0417-1665 178 µM 1.17411355321278 0.113811448436346 no 386 0.120174772747415 639 3429856
SGTC_3136 9095672 49.47 µM 1.17208535776103 0.114217600206002 no 387 0.120581393972698 567 17217380
SGTC_1276 0871-0068 94.2 µM 1.1720759738977 0.114219481746541 no 388 0.120583277538099 616 3414906
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.16768427871501 0.115102476080389 no 389 0.121467070285046 679 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_586 0957-0265 8.15 µM 1.1635729664871 0.115933485446832 no 390 0.122298556075885 566 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_466 geldanamycin 89.2 µM 1.15832268750761 0.117000892608663 no 391 0.123366188118618 514 5288382 HSP90 inhibitor.
SGTC_2934 9036370 36.88 µM 1.15692158206449 0.117286917690429 no 392 0.123652200127034 686 6462800
SGTC_1927 st060202 13.8 µM 1.15603127720747 0.117468923828843 no 393 0.123834181903334 645 688887
SGTC_1382 3002-2117 298 µM 1.15585604578984 0.117504770148389 no 394 0.123870021956793 704 1497314
SGTC_57 miconazole 162.5 nM 1.15536759880187 0.117604730477234 no 395 0.123969962263396 629 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_161 4065-0411 162.148 µM 1.1541257305695 0.117859148963859 no 396 0.124224312886788 705 1906281 YLR208W SEC13
SGTC_2827 7993847 71.43 µM 1.1530162947313 0.118086765493972 no 397 0.12445184817841 599 2985692
SGTC_1887 st057648 70.8 µM 1.15247670984225 0.118197581309783 no 398 0.124562617443116 667 688672
SGTC_2202 7226349 200 µM 1.14928905044295 0.118853738875058 no 399 0.125218405792095 633 844334
SGTC_1003 4049-0218 100 µM 1.14919903038983 0.118872306157421 no 400 0.125236960304069 686 295161
SGTC_1086 cerivastatin 2.18 µM 1.1489993074738 0.118913507757362 no 401 0.125278133110627 635 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2741 miltefosine 3.04 µM 1.14681164532469 0.119365469233726 no 402 0.125729737602845 552 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1620 st003704 16.5 µM 1.14637757076213 0.119455291079261 no 403 0.125819479540675 683 2834414
SGTC_922 1866-0035 480 µM 1.14228979041462 0.120303503694 no 404 0.126666791803072 772 3156169
SGTC_2916 7875993 68.79 µM 1.13981935866102 0.120818169436385 no 405 0.127180783435465 673 1299250
SGTC_898 1000-0849 28.3 µM 1.13490828020918 0.121845893511534 no 406 0.128206875110465 697 6751807
SGTC_2984 9022109 38.96 µM 1.13303663013798 0.122239178824271 no 407 0.128599435528143 652 6459207
SGTC_3165 9101544 49.47 µM 1.13292867177154 0.122261891007806 no 408 0.128622104163804 673 5002184
SGTC_109 0132-0036 33.701 µM 1.13228637997578 0.122397077014882 no 409 0.128757027168316 545 67274 A color developer.
SGTC_1548 st061468 90.8 µM 1.13178215403563 0.122503277166209 no 410 0.128863016149807 695 390799
SGTC_34 0469-0683 81.75 µM 1.13148884650911 0.122565083382689 no 411 0.128924697625393 672 3690923
SGTC_1020 4335-0961 93.3 µM 1.13086079401235 0.122697501149166 no 412 0.129056843575042 634 669075
SGTC_553 k007-0256 45.7 µM 1.1292673129808 0.123033918794346 no 413 0.129392542715574 685 6287000
SGTC_332 4112-0506 40.9 µM 1.12025973146668 0.124947768036642 no 414 0.131301548329869 686 2790355
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.11749967224465 0.125538341181414 no 415 0.13189036982232 513 6708630 An antioxidant.
SGTC_1617 st002906 78 µM 1.11728750479887 0.125583819392004 no 416 0.131935708163263 713 5150859
SGTC_975 1335-0046 28.5 µM 1.11692217803203 0.125662154325887 no 417 0.132013800510047 676 16486740
SGTC_1645 Cervolide 78 µM 1.1135028174759 0.126397001261101 no 418 0.132746269473022 664 23173 A fragrance.
SGTC_201 4262-0159 12.803 µM 1.11179456310276 0.126765237678619 no 419 0.13311324502699 611 1341029
SGTC_1621 st003705 32.4 µM 1.10967357744534 0.127223482301323 no 420 0.133569856387999 761 24207032
SGTC_295 k015-0027 31 µM 1.10957415747618 0.127244990491655 no 421 0.133591286175505 693 3887424
SGTC_2871 9038510 12.99 µM 1.10867369893241 0.127439907953578 no 422 0.133785486000978 743 4945164
SGTC_2393 9031399 185.94 µM 1.10799471329464 0.127587021606701 no 423 0.133932049546212 694 1526623 YDL150W RPC53
SGTC_2437 5741531 144.16 µM 1.1069383936902 0.127816125659112 no 424 0.134160282416349 739 2262990
SGTC_335 4077-0256 27.6 µM 1.10622405612471 0.127971219537166 no 425 0.134314776545921 782 3121989
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.10565318794662 0.128095257924055 no 426 0.134438329479162 730 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1808 st050063 61.5 µM 1.10454738205946 0.128335765212707 no 427 0.134677880833237 700 4011993
SGTC_700 3453-2283 142 µM 1.10448998473869 0.128348257398407 no 428 0.134690322839279 758 565664
SGTC_2529 gangaleoidin 93.61 µM 1.10405237850892 0.128443527548686 no 429 0.134785208589109 703 4565183
SGTC_2582 agaric acid 100 µM 1.0996428303519 0.129406258994323 no 430 0.135743886417427 905 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2867 9039098 71.43 µM 1.09877353862329 0.12959663894705 no 431 0.135933428473555 694 6463460
SGTC_1993 st073995 70.8 µM 1.09856847356635 0.129641577657191 no 432 0.13597816765934 719 3098394
SGTC_3100 9120536 49.47 µM 1.09803843741517 0.1297577817267 no 433 0.136093852712887 579 16421196
SGTC_354 2783-3500 4.88 µM 1.09657732152923 0.130078487268646 no 434 0.13641310284923 693 6740761
SGTC_358 0075-0058 9.45 µM 1.09531450087478 0.13035610990232 no 435 0.136689438394943 785 1069125
SGTC_544 k015-0020 52.4 µM 1.0944428558183 0.130547974137779 no 436 0.136880398419126 693 3008304
SGTC_1268 0828-0275 2.46 µM 1.09362884660058 0.130727327977243 no 437 0.137058896159163 747 745337
SGTC_776 4476-4378 112 µM 1.09033202764832 0.131455470578896 no 438 0.137783455920805 674 2892008
SGTC_2905 7799065 20.05 µM 1.08877065338076 0.131801294292894 no 439 0.13812751799082 681 1296806
SGTC_589 1227-0070 34.1 µM 1.08363015801217 0.132944278411997 no 440 0.139264406842442 721 2841384
SGTC_3156 9099931 49.47 µM 1.07693630014458 0.134442853603408 no 441 0.14075436229343 758 18111053
SGTC_2974 9094440 9.66 µM 1.0765578258523 0.134527928881572 no 442 0.140838927042275 744 25236134
SGTC_181 1447-1644 8.07 µM 1.07648135590628 0.134545122651921 no 443 0.140856017359403 732 534600
SGTC_1236 0330-0013 258 µM 1.07416881696523 0.13506579465316 no 444 0.141373512838723 707 4617066
SGTC_734 2023-0417 80 µM 1.07387587960971 0.13513184845927 no 445 0.141439157629389 717 3935732
SGTC_3162 9099653 49.47 µM 1.07298043542582 0.135333897541797 no 446 0.141639947181917 671 25237511
SGTC_543 3844-1095 191 µM 1.07147835637588 0.135673293253826 no 447 0.14197719870217 789 4230703
SGTC_8 0354-0001 70 µM 1.07144370524597 0.135681129572676 no 448 0.141984985092895 833 4993152
SGTC_1572 epiandrosterone 68.9 µM 1.06560442940669 0.137006105991252 no 449 0.143301248033676 781 441302 A steroid.
SGTC_2858 9025781 8.96 µM 1.06320449030494 0.13755322576417 no 450 0.143844613266088 835 4894980 YPL153C RAD53
SGTC_1389 3405-0187 19 µM 1.06213165643218 0.137798283956598 no 451 0.144087960327719 672 799890
SGTC_387 norethindrone acetate 66.7 µM 1.0619303164471 0.13784430749133 no 452 0.144133660474335 697 541197
SGTC_2216 7189485 200 µM 1.06077986399856 0.138107486157206 no 453 0.144394977607022 767 731273
SGTC_2168 5727979 200 µM 1.06076780344782 0.138110246954634 no 454 0.14439771876585 670 695210
SGTC_12 0849-0099 9.267 µM 1.06019986790999 0.138240296481948 no 455 0.144526840599835 734 6071388
SGTC_2925 9010536 32.5 µM 1.05955267450095 0.13838859673191 no 456 0.144674076755034 806 2994177
SGTC_1791 st048313 56.1 µM 1.05723656335255 0.138920207008955 no 457 0.145201818338189 686 1204976
SGTC_972 1319-0219 195 µM 1.05535329355327 0.139353492157659 no 458 0.145631887826336 739 23903702
SGTC_2760 etidronate 98.04 µM 1.05493644328077 0.13944952132096 no 459 0.145727196728615 699 3305 A chelator and antioxidant.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.05443842877738 0.139564307164494 no 460 0.145841118030308 715 616764
SGTC_941 3237-0776 460 µM 1.05420122551118 0.139619002006433 no 461 0.145895399545824 717 760008
SGTC_408 cantharidin 100 µM 1.04402364119676 0.141979506313469 no 462 0.148237225946352 772 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2756 carbadox 75.1 µM 1.04277298892048 0.142271425333716 no 463 0.148526722087008 738 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1603 st002045 67.8 µM 1.04208997670649 0.142431020887011 no 464 0.148684982603314 775 5887985
SGTC_899 1083-0020 478 µM 1.04195491862269 0.142462593471233 no 465 0.148716290207473 784 767123
SGTC_2333 9017922 200 µM 1.04019724419362 0.142873917437582 no 466 0.149124135795116 756 3163164
SGTC_2598 perillyl alcohol 100 µM 1.03901540890867 0.1431509366736 no 467 0.149398784995893 779 10819 An apoptosis inducer.
SGTC_193 1273-0060 1.558 µM 1.0344600694031 0.144222089718107 no 468 0.150460567415886 661 2847393 YHR072W ERG7
SGTC_961 1252-1571 372 µM 1.03243072627093 0.144701009470609 no 469 0.150935192038188 784 6813498
SGTC_1501 4491-0275 38.4 µM 1.03151296546048 0.144917950016199 no 470 0.15115016565871 791 5104718
SGTC_1115 galangin 695.678 nM 1.03086157255963 0.145072059243462 no 471 0.151302869576782 819 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3201 9113999 49.47 µM 1.03077874214168 0.14509166350834 no 472 0.151322294592954 737 16649224
SGTC_1189 1431-2119 7.28 µM 1.02672233140325 0.146053914934956 no 473 0.152275615404527 804 3107275
SGTC_2649 anisomycin 9.56 µM 1.02669917088934 0.146059421293865 no 474 0.152281069914726 765 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1686 st019653 115.5 µM 1.02483016095083 0.14650423386533 no 475 0.152721666209337 784 97252
SGTC_2131 toluylene red 5.2905 µM 1.02383862755101 0.14674058132902 no 476 0.152955751052375 754 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1320 1313-0481 95.3 µM 1.02136034767459 0.147332436269643 no 477 0.153541872269151 824 6813365 YLR208W SEC13
SGTC_1141 3253-0389 52.6 µM 1.0206002249024 0.147514286531856 no 478 0.153721941439701 776 5402031
SGTC_3138 9097216 49.47 µM 1.01946078823599 0.147787164641034 no 479 0.153992129873572 809 25237486
SGTC_149 3970-0822 46.1 µM 1.0193759271958 0.147807501111437 no 480 0.154012265076452 899 3114250 YBL034C STU1
SGTC_2231 micatex 6.853 µM 1.01893876115139 0.147912295180977 no 481 0.154116020217302 764 20737 An antifungal of unknown mechanism.
SGTC_3268 9137683 49.47 µM 1.01634994487661 0.148533885441147 no 482 0.154731386379046 766 1953228
SGTC_530 4358-1714 28 µM 1.01583047360111 0.148658823697805 no 483 0.154855060905348 832 1564641
SGTC_1084 voriconazole 435 nM 1.01080207982768 0.149871835563025 no 484 0.156055583743651 811 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1776 st049249 45.9 µM 1.00637439063186 0.150945388558179 no 485 0.157117753959443 804 1822314
SGTC_979 1426-2828 121 µM 1.00598202601727 0.151040768917507 no 486 0.157212108153238 842 747872
SGTC_4 0960-0234 25.671 µM 1.0052472124525 0.151219503446259 no 487 0.157388913236187 759 6821112
SGTC_129 0088-0017 176.636 µM 1.00410116542314 0.151498546283678 no 488 0.157664926877243 765 182446
SGTC_2826 7992541 19.48 µM 1.00291581710872 0.151787518246256 no 489 0.157950740167907 762 2985066
SGTC_1365 1672-3266 55.4 µM 1.00103058570649 0.152247866305421 no 490 0.158406010860745 828 6415873
SGTC_3042 9091578 49.47 µM 1.0002763714102 0.152432294576221 no 491 0.158588389382096 783 25236497
SGTC_1119 parthenolide 318.541 nM 0.996543103818413 0.153347374317397 no 492 0.159493167393175 868 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2373 9071805 200 µM 0.996297242686832 0.153407766024231 no 493 0.159552871556578 818 10149009
SGTC_864 0469-0573 172 µM 0.996274025633516 0.153413469722088 no 494 0.159558510270434 761 689425
SGTC_2526 patulin 37.61 µM 0.994449359005472 0.153862172123964 no 495 0.160002074047773 841 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1129 3453-1384 223 µM 0.993296982491881 0.154145999213961 no 496 0.16028262381961 843 1084452
SGTC_2724 maprotiline 69.64 µM 0.992104174776432 0.15444014893436 no 497 0.160573355121178 829 4011 A tricyclic antidepressant.
SGTC_1834 st055981 52.8 µM 0.988376255083578 0.155361855058791 no 498 0.161484206048784 829 471719 YDL150W RPC53
SGTC_3030 9087619 49.47 µM 0.986594349523338 0.155803700306487 no 499 0.161920770693642 814 25236973
SGTC_3312 9133330 71.43 µM 0.985381049086205 0.156105026645217 no 500 0.162218467384671 871 17617324
SGTC_1804 st050076 49.1 µM 0.985118492478417 0.156170283774433 no 501 0.162282935426068 814 3895976
SGTC_2177 5811945 192 µM 0.983631908575539 0.156540105693035 no 502 0.16264826514316 808 5343475
SGTC_451 chloral hydrate 100 µM 0.982735963959932 0.156763270760715 no 503 0.162868702759892 877 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2514 salinomycin 42.74 µM 0.981980441769956 0.15695162155632 no 504 0.163054741847324 902 23682228 A polyether potassium ionophore.
SGTC_2174 5790901 200 µM 0.98004198354342 0.157435557657704 no 505 0.163532697603894 799 786020
SGTC_496 calpeptin 138 µM 0.978630220093134 0.157788620963317 no 506 0.16388136091751 730 73364 A calpain inhibitor.
SGTC_1393 3470-5649 58.2 µM 0.978383920930428 0.157850270351781 no 507 0.163942238824202 709 4108395
SGTC_642 0335-0876 158 µM 0.975662276407925 0.15853255881262 no 508 0.164615926062823 828 6812350
SGTC_3311 9131146 2.8755 µM 0.975341627069188 0.15861306949277 no 509 0.164695414181589 820 4900406 YPR165W RHO1
SGTC_2394 5221648 200 µM 0.975092018366103 0.158675761393068 no 510 0.164757308726294 923 788586
SGTC_884 0851-0618 334 µM 0.974603474480812 0.158798511435501 no 511 0.16487849474457 848 9642473
SGTC_2061 5245884 80.95 µM 0.974436334869679 0.158840520709414 no 512 0.164919967901725 831 573863
SGTC_2029 5175081 200 µM 0.973557023213205 0.15906164897978 no 513 0.165138266991204 851 1380876
SGTC_276 colchicine 750 µM 0.972830383147476 0.159244535701315 no 514 0.165318804711622 850 2833 A microtubule depolymerizer.
SGTC_1746 st038117 42 µM 0.971413138684399 0.159601635481031 no 515 0.165671294216904 804 2898218
SGTC_1244 0416-0015 52.5 µM 0.969409348048784 0.160107419548751 no 516 0.166170495032029 814 96201
SGTC_2475 5812728 15.03 µM 0.969178497075622 0.160165756728379 no 517 0.166228068882343 892 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3187 9109394 49.47 µM 0.968201916589443 0.160412697144238 no 518 0.166471768959194 818 17098090
SGTC_1102 cgs 12066b 26.1 µM 0.968003888639226 0.16046280127418 no 519 0.166521213815526 799 6438352 A 5-HT1B full agonist.
SGTC_2035 5154463 94.595 µM 0.967969352017574 0.160471540619881 no 520 0.166529838105834 835 2769623
SGTC_3309 9129340 25.759 µM 0.96735067621128 0.16062814658944 no 521 0.166684379179812 892 17158987
SGTC_1116 jasmonic acid 1.58368 µM 0.9654212395565 0.161117187509652 no 522 0.167166933694073 844 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_435 c-PAF 6.7 µM 0.963534323105233 0.161596389783771 no 523 0.167639724031767 857 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1126 isoteolin 1.0172 µM 0.963498501592987 0.161605496010996 no 524 0.167648707878362 803 133323
SGTC_1436 4092-1007 8.32 µM 0.963349391331543 0.161643405093763 no 525 0.167686107278246 824 2881121
SGTC_2020 4017018 200 µM 0.962680296252843 0.16181358399641 no 526 0.167853993893343 818 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2537 larixol 68.93 µM 0.962559428757512 0.161844338107826 no 527 0.167884333009207 889 6708759
SGTC_628 1636-0253 16 µM 0.961196381845393 0.162191421998161 no 528 0.168226717640507 852 4456143
SGTC_1148 3909-7663 27.7 µM 0.959927860746031 0.162514871081366 no 529 0.168545761530465 867 4084526
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.959923023969433 0.162516105171361 no 530 0.168546978765043 880 688664
SGTC_1081 sertraline 6 µM 0.959712251937465 0.162569888987342 no 531 0.168600027639584 874 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1430 4049-0248 69.1 µM 0.958825663881762 0.162796251154061 no 532 0.168823289076487 937 22774488
SGTC_2336 9001819 198.65 µM 0.95864789056423 0.16284166459702 no 533 0.168868078973656 861 2989602
SGTC_218 alverine citrate 93.75 µM 0.958578159210369 0.162859480210507 no 534 0.168885649837342 816 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_334 1502-1024 68.5 µM 0.958322629058028 0.162924776257123 no 535 0.168950048206124 869 3296216
SGTC_1300 1094-0077 113 µM 0.958270863467456 0.162938006078015 no 536 0.168963096022519 793 5532636
SGTC_555 4296-0685 37 µM 0.957691268628003 0.16308618181515 no 537 0.169109230446595 887 2908540 YHR072W ERG7
SGTC_2161 5662504 8.5105 µM 0.957205290996239 0.163210491423695 no 538 0.16923182351203 784 2859334
SGTC_2630 antimycin a 100 µM 0.956753542592923 0.163326100643947 no 539 0.16934583304404 886 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1251 0490-5699 265 µM 0.956183285306093 0.163472114019813 no 540 0.169489821508952 920 3883818
SGTC_2663 amphotericin b 100 µM 0.956114798264251 0.163489655707054 no 541 0.169507119589233 813 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_87 0100-0052 35.5 µM 0.955523712562192 0.163641102164348 no 542 0.169656459839267 1036 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2334 9017922 200 µM 0.954294388045673 0.163956368135977 no 543 0.169967323969992 872 3163164
SGTC_1272 0839-0021 27 µM 0.954254790965972 0.163966529537756 no 544 0.169977343105761 858 5027250
SGTC_2347 9049783 174.81 µM 0.953066576744157 0.164271639138099 no 545 0.17027816967494 888 6467988 YPL169C MEX67
SGTC_119 0121-0043 24.815 µM 0.951744966068782 0.164611434454724 no 546 0.170613169350611 1013 1092378
SGTC_189 3970-0742 2.116 µM 0.949257294626211 0.165252266697966 no 547 0.171244883900657 864 2891807
SGTC_1208 2323-2347 50.3 µM 0.947448674859835 0.165719185252278 no 548 0.171705099021694 880 5412760
SGTC_817 1391-0715 46 µM 0.946375333892943 0.165996685006555 no 549 0.171978590852319 817 1353946
SGTC_2794 7785382 27.27 µM 0.944497359895222 0.166482935084218 no 550 0.172457775170912 930 2205081
SGTC_2495 cafestol 54.53 µM 0.943626727681055 0.166708673164131 no 551 0.172680214530391 798 16667697 An anti-infammatory.
SGTC_1559 coumarin 343 70.1 µM 0.94309672839701 0.166846188386691 no 552 0.172815714504091 817 108770 A hepatotoxic, DNA x-linker.
SGTC_2627 acetyl isogambogic acid 100 µM 0.942544990238401 0.166989421760821 no 553 0.17295684422338 813 6857789 A caspase activator and apoptosis inducer.
SGTC_3004 9076122 71.4286 µM 0.941900014643503 0.167156960439214 no 554 0.173121916318982 866 44782551
SGTC_2093 5331342 194.4 µM 0.940391297322031 0.167549287490172 no 555 0.173508442264779 889 33839
SGTC_23 0213-0011 39.996 µM 0.939587736176855 0.167758487540211 no 556 0.173714534662053 858 627608
SGTC_1685 st024049 53.0905 µM 0.932933452994995 0.169497330856412 no 557 0.175427164358498 856 1941139
SGTC_1150 3909-7983 10.9 µM 0.929355503645916 0.170437055273847 no 558 0.176352439814887 862 23965914
SGTC_1831 st055328 12 µM 0.927892230631852 0.170822333618562 no 559 0.176731737485463 889 1103068
SGTC_2541 muurolladie-3-one 83.07 µM 0.927607191290874 0.170897449004336 no 560 0.176805683028138 837 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2391 6285546 200 µM 0.926358606582591 0.171226733010409 no 561 0.177129824079788 884 846083
SGTC_1814 st052110 31.539 µM 0.925304233794812 0.171505114038538 no 562 0.177403838547274 877 674163
SGTC_1847 st056231 15 µM 0.923453274166794 0.171994513206833 no 563 0.17788551995084 933 5393180
SGTC_2182 6325192 200 µM 0.922327328593213 0.17229265220827 no 564 0.178178931631479 851 736248
SGTC_1602 st001878 87.6 µM 0.921132576017025 0.172609370948668 no 565 0.178490607198991 890 595405 YLR310C CDC25
SGTC_373 0844-0104 25.9 µM 0.920829622273412 0.172689740370234 no 566 0.178569693407642 942 5375804
SGTC_1324 1418-0026 34.4 µM 0.920757625916113 0.172708843511881 no 567 0.178588491333599 903 1372513
SGTC_3261 9137475 49.47 µM 0.920184570291479 0.172860943162724 no 568 0.178738158020106 706 17027690
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.919288920439883 0.173098836250526 no 569 0.178972235733145 937 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_316 k060-0003 58.6 µM 0.918013405045699 0.173437985000379 no 570 0.179305923952975 870 6152314
SGTC_2897 9048598 12.99 µM 0.916838916643032 0.173750645299553 no 571 0.179613528188514 851 6467404
SGTC_478 N-arachidonylglycine 10 µM 0.916725256505773 0.173780921755598 no 572 0.179643313921294 790 5283389
SGTC_2343 7990716 14.84 µM 0.916580721587457 0.173819427392421 no 573 0.179681195170399 896 6456862
SGTC_2075 5212009 200 µM 0.915224642910024 0.174180965415079 no 574 0.180036855121667 818 780898
SGTC_2372 9071633 200 µM 0.913813362269419 0.174557727702086 no 575 0.1804074619642 963 21321366
SGTC_2363 9053361 176 µM 0.913245843497554 0.174709381047243 no 576 0.180556629059697 903 6469797 YMR079W SEC14
SGTC_2918 7977171 22.06 µM 0.911239124936898 0.175246290376053 no 577 0.181084696695559 892 2236483
SGTC_493 zm226600 134 µM 0.910870511623872 0.175345028668763 no 578 0.181181802309264 897 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3210 9128157 49.47 µM 0.907287878367028 0.176306524388978 no 579 0.182127291294347 793 17590849
SGTC_1452 4194-0072 190 µM 0.906903481887111 0.176409885306295 no 580 0.182228919864607 976 1343545
SGTC_2101 5377231 179.231 µM 0.906538154434096 0.176508154247851 no 581 0.182325539716642 907 2844213
SGTC_2436 5633522 8.09 µM 0.903068232784612 0.177443249389884 no 582 0.183244841324185 940 5724242
SGTC_2221 6807166 181.081 µM 0.901961784155191 0.177742078138833 no 583 0.183538584407583 851 674925
SGTC_2025 5147754 141 µM 0.900546850482373 0.178124684596687 no 584 0.183914652308088 913 315777 YLR208W SEC13
SGTC_1511 0906-3109 28.5 µM 0.899827443974529 0.178319415325694 no 585 0.184106043525155 1001 2882180
SGTC_1938 st074717 56.4 µM 0.899073827861158 0.178523549801496 no 586 0.18430666879601 846 17250979
SGTC_1526 st051518 75 µM 0.898941796737022 0.178559328653067 no 587 0.184341831698738 837 673993
SGTC_2227 7312221 64.1025 µM 0.896139197284283 0.179319864628319 no 588 0.185089212308216 944 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1652 st011932 78 µM 0.893881054304267 0.179934132025609 no 589 0.185692767763714 903 1551076
SGTC_2304 7443016 91.4 µM 0.892985684647998 0.180178058815301 no 590 0.185932419440879 838 939854
SGTC_603 3794-0023 45.9 µM 0.892338161130083 0.180354593807717 no 591 0.186105852885791 912 3802260
SGTC_341 1486-1430 230 µM 0.891132210567932 0.180683662492542 no 592 0.186429123250891 906 2054753 YPL210C SRP72
SGTC_385 1494-0393 12.4 µM 0.890652009780473 0.180814799993996 no 593 0.186557943937677 926 3090647
SGTC_566 0958-0068 16.5 µM 0.888222858683314 0.181479088077248 no 594 0.187210442589677 858 6815365
SGTC_1413 3910-0535 34.4 µM 0.886963593305207 0.181824053693001 no 595 0.18754925086302 971 2876951
SGTC_1335 1486-0900 202 µM 0.886143552069121 0.182048917761628 no 596 0.187770088436369 943 X1335
SGTC_2450 5739737 12.93 µM 0.885125668900193 0.182328273935817 no 597 0.188044428254761 878 2262825
SGTC_1924 st058459 75.1 µM 0.884612280245093 0.18246927407766 no 598 0.18818289055442 916 688683
SGTC_1139 k015-0024 46.9 µM 0.884240648854313 0.18257138364013 no 599 0.18828315978339 953 2766652
SGTC_758 0868-0029 16 µM 0.88411378032061 0.182606250249064 no 600 0.188317397510771 962 762687
SGTC_432 NS 1619 61.3 µM 0.883121871144118 0.182878994735085 no 601 0.188585214206134 860 4552 A K+/calcium channel activator.
SGTC_1835 st008666 49.2 µM 0.88179068369573 0.18324542964204 no 602 0.188945005293779 831 690455
SGTC_748 act1.228 77.9 µM 0.877755723564062 0.18435892465734 no 603 0.190038148574071 944 4421505 YNR035C ARC35
SGTC_1489 4065-0444 182 µM 0.875587854988097 0.184958908369602 no 604 0.190627065098393 922 2877968
SGTC_3013 9080133 71.4286 µM 0.875494889490161 0.184984664791232 no 605 0.190652344845204 991 17050193
SGTC_1700 st030840 7.9285 µM 0.873576409111726 0.185516684028321 no 606 0.191174489054036 966 5499307
SGTC_1579 chlormadinone acetate 49.4 µM 0.872962426053712 0.185687149803086 no 607 0.191341779091983 964 45114258 A steroidal progestin.
SGTC_2492 derrusnin 100 µM 0.872202101544202 0.185898380336455 no 608 0.191549066626663 867 1715307 Part of coumarin class of compounds.
SGTC_2424 5537928 59.2 µM 0.871435159913036 0.186111600108095 no 609 0.191758297499451 974 5382802
SGTC_3291 9121177 71.43 µM 0.867795662080808 0.187125493077544 no 610 0.192753102604518 854 17015612
SGTC_1499 4480-0877 67.3 µM 0.867226184615234 0.187284446899429 no 611 0.19290904599747 898 2861909
SGTC_331 k048-0133 24.5 µM 0.867096715454014 0.187320596264772 no 612 0.192944510054015 909 6813582
SGTC_3006 9075424 71.4286 µM 0.866735969712301 0.187421343618882 no 613 0.193043346150447 910 7465181
SGTC_1506 4226-2149 212 µM 0.864190965596598 0.188133051495344 no 614 0.193741497168984 1003 991114
SGTC_904 1141-0088 396 µM 0.862318093625429 0.188657862155925 no 615 0.194256249350167 935 1378119
SGTC_3173 9105693 49.47 µM 0.86018569359387 0.189256494555459 no 616 0.194843344795711 994 17096658
SGTC_133 0724-0033 378.92 µM 0.859769063129165 0.189373592377849 no 617 0.194958177987872 919 280309
SGTC_173 1273-0061 2.693 µM 0.859428009283632 0.189469481882827 no 618 0.195052211103431 920 2847414 YPL266W DIM1
SGTC_485 niflumic acid 177 µM 0.859047984032408 0.18957636364005 no 619 0.195157021628707 940 4488 A COX2 inhibitor.
SGTC_3108 9121785 49.47 µM 0.858557857048905 0.189714266169148 no 620 0.195292248614607 958 17140271
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.853588660625494 0.191115884724751 no 621 0.19666647180812 967 7104
SGTC_2869 9037858 32.47 µM 0.851481702621199 0.191712088229613 no 622 0.197250911607421 975 27187042
SGTC_1376 2910-0861 41.3 µM 0.851277165704915 0.191770026396672 no 623 0.197307703096525 996 1112859
SGTC_2116 5511452 16.8835 µM 0.851222304600349 0.191785568455461 no 624 0.19732293745085 964 870744
SGTC_2742 clothiapine 36.27 µM 0.850741656369243 0.191921768267908 no 625 0.197456438851945 922 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_31 0508-1974 57.237 µM 0.850391774750624 0.19202095037263 no 626 0.197553653797581 949 6810525
SGTC_3017 9080681 49.47 µM 0.845784411138528 0.193329939379607 no 627 0.198836511693941 946 16451914
SGTC_827 3253-0474 693 µM 0.844972231416354 0.193561249414436 no 628 0.199063171638864 1015 5402065
SGTC_1456 k015-0012 13 µM 0.84494651677187 0.193568575740402 no 629 0.199070350522932 1062 2989616
SGTC_774 k060-0086 136 µM 0.844060893762238 0.193821000648147 no 630 0.199317689448991 1051 5911235
SGTC_2143 5623677 140.463 µM 0.843688729036838 0.193927136836929 no 631 0.199421683706667 965 5375313
SGTC_2267 7931562 200 µM 0.840352025311124 0.194880299724457 no 632 0.200355519734917 885 934880
SGTC_2196 6573537 42.6665 µM 0.840282174813655 0.194900283616794 no 633 0.200375096673294 999 2903087
SGTC_1911 st060208 74.3 µM 0.838321798098304 0.195461646139076 no 634 0.200924998322547 1000 688783
SGTC_2701 st077767 14.721 µM 0.835473900545138 0.196278901570418 no 635 0.201725468006902 1005 5721188
SGTC_2081 5214970 32.255 µM 0.834764001319809 0.196482942029415 no 636 0.201925299135556 997 2063512
SGTC_3269 9137823 49.47 µM 0.832520529009687 0.197128609180802 no 637 0.202557597749363 915 17682936
SGTC_1719 st032227 49.2 µM 0.832173343628555 0.19722864308027 no 638 0.20265555387011 1014 3125804
SGTC_3124 9127567 49.47 µM 0.831018063856914 0.197561732817614 no 639 0.202981712403712 969 17592030
SGTC_3195 9113082 49.47 µM 0.830943134506212 0.197583348150994 no 640 0.20300287727447 987 17018038
SGTC_446 go6976 132 µM 0.830846118607044 0.197611337051386 no 641 0.203030282765626 987 3501 A protein kinase C inhibitor.
SGTC_824 1304-0008 100 µM 0.830099125164198 0.197826923480913 no 642 0.203241370843876 992 768245
SGTC_2994 9053520 71.4286 µM 0.829842445665382 0.197901035391305 no 643 0.203313934481265 999 4647384
SGTC_1644 st010134 20.9 µM 0.82911260568455 0.198111856098878 no 644 0.203520345678611 984 3818134
SGTC_190 3970-0790 3.722 µM 0.828383728563431 0.198322533952277 no 645 0.20372660925692 975 2832352
SGTC_3275 9138069 49.47 µM 0.825827942006315 0.199062337362666 no 646 0.204450850579148 991 17617007
SGTC_3316 9136639 10.545 µM 0.825572013792341 0.199136510363575 no 647 0.204523458079721 994 4903665
SGTC_2935 9038016 29.96 µM 0.824373225713781 0.199484164172345 no 648 0.20486376160028 1030 6463195
SGTC_2886 9058944 51.95 µM 0.823038032520084 0.199871805816234 no 649 0.205243182914978 870 4949929
SGTC_2103 5378138 10 µM 0.820286178261551 0.200672169050603 no 650 0.206026491947628 1084 244142
SGTC_2719 novobiocin 32.65 µM 0.819387519101464 0.200933955817136 no 651 0.206282676747063 980 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2065 5221596 34.26 µM 0.819046393771067 0.201033382044285 no 652 0.206379972292063 976 788581
SGTC_874 0599-0792 117 µM 0.818819937408787 0.201099402531222 no 653 0.206444577043943 1078 765305
SGTC_2162 5663267 200 µM 0.817782589596736 0.201401994334353 no 654 0.206740670616308 1044 6456493
SGTC_2379 9035213 200 µM 0.815871882491114 0.201960056599644 no 655 0.20728670760281 1057 646551
SGTC_882 0843-0131 351 µM 0.815152229463848 0.202170486161814 no 656 0.207492589088721 1068 5425421
SGTC_1793 st048256 72.231 µM 0.814236283289554 0.20243850230917 no 657 0.207754801705901 988 672022
SGTC_2292 7671323 168.05 µM 0.814018423836248 0.202502281695828 no 658 0.207817198252913 1001 937504
SGTC_568 1193-0097 7.48 µM 0.813922069931491 0.202530493588821 no 659 0.207844798248313 988 3646150
SGTC_2491 paeonol 100 µM 0.810884514109745 0.203421077284439 no 660 0.208715997094001 1008 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1519 esterone 74 µM 0.810417925259105 0.203558083592141 no 661 0.208850009479945 1006 698 A steroid.
SGTC_2985 9022375 71.43 µM 0.810244700550328 0.203608962245756 no 662 0.208899775513508 1060 4939335
SGTC_2655 perillic acid 100 µM 0.81008994722278 0.203654421995237 no 663 0.208944240779024 1010 5702197 An apoptosis inducer.
SGTC_2305 7443522 69.23 µM 0.807910060023183 0.20429542020892 no 664 0.209571179816245 1034 5415886
SGTC_2051 5263410 176 µM 0.806365972782772 0.204750186688506 no 665 0.210015930460559 1098 227584
SGTC_1784 st039334 36.3 µM 0.804615224086424 0.205266547071297 no 666 0.210520877055844 1032 3496984
SGTC_2805 7950783 58.44 µM 0.803303972404829 0.205653789774016 no 667 0.210899531247613 1046 1178958 YDL195W SEC31
SGTC_186 3455-3465 67.277 µM 0.803002034819306 0.205743020251347 no 668 0.210986779228351 985 755278
SGTC_619 1652-1634 108 µM 0.802419588280395 0.205915213376766 no 669 0.211155142931791 953 5400454
SGTC_1908 st060353 56.5 µM 0.80174702346337 0.20611415517301 no 670 0.21134965440204 1073 4227716
SGTC_3214 9129694 49.47 µM 0.80021585803906 0.206567492197069 no 671 0.211792871732296 1004 17158655
SGTC_2059 5238311 157 µM 0.799097502592628 0.2068989801558 no 672 0.212116938827599 1016 703021
SGTC_2229 7354935 190 µM 0.797285634834608 0.207436697484483 no 673 0.212642580647322 1008 318112
SGTC_2159 5658611 73.75 µM 0.797266456515736 0.207442393547684 no 674 0.21264814854383 1079 793844
SGTC_2656 pseudo-anisatin 100 µM 0.796456785224514 0.207682954584539 no 675 0.212883291954789 1057 6708809 A neurotoxin.
SGTC_709 3807-1509 243 µM 0.796366077890884 0.207709914857757 no 676 0.212909644479695 1047 1886677 YPL242C IQG1
SGTC_2669 eugenol 100 µM 0.795766077119112 0.207888300734043 no 677 0.213084006166734 1019 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2256 7954252 200 µM 0.79543907125661 0.207985560730801 no 678 0.21317906992784 925 2972920
SGTC_70 0141-0289 43.283 µM 0.794088854048312 0.208387434591941 no 679 0.213571852934774 1141 352408
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.791472334740716 0.209167508566765 no 680 0.214334206946678 1041 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.78958276140991 0.209731922626383 no 681 0.214885739487154 1093 94937 An inhibitor of serotonin biosynthesis.
SGTC_2957 9076800 11.52 µM 0.788311534997547 0.210112140310835 no 682 0.215257251066393 994 16459615
SGTC_491 tetrandrine 80.3 µM 0.788272558498555 0.210123804387865 no 683 0.215268647701729 1036 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_39 0986-0283 58.349 µM 0.784781047157978 0.211170213736523 no 684 0.21629097711154 1104 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2992 9074591 71.4286 µM 0.784618987703242 0.211218857156077 no 685 0.216338496969223 1034 17741321
SGTC_2050 5263056 171 µM 0.782654920418694 0.211808909146688 no 686 0.216914890542409 1094 763468 YGL055W OLE1
SGTC_3107 9121808 49.47 µM 0.779516987913933 0.212753616550145 no 687 0.217837617247955 1038 662681
SGTC_2412 st077135 33.4 µM 0.779427966817423 0.212780453116514 no 688 0.217863827383171 1047 13258915
SGTC_2980 9014342 25.29 µM 0.77868608965473 0.213004178473367 no 689 0.218082326115252 1001 2996599
SGTC_294 k038-0071 157 µM 0.778609696586088 0.21302722386122 no 690 0.218104832682931 1073 24152826
SGTC_2041 5107442 45.335 µM 0.777909384268379 0.213238553860096 no 691 0.218311217796392 1091 793005
SGTC_1314 1222-0010 41.1 µM 0.776585910669118 0.213638266008242 no 692 0.218701558344723 1062 3526027
SGTC_759 3486-0358 89.3 µM 0.775506056347019 0.213964724015701 no 693 0.219020344075672 1112 875103
SGTC_2580 diallyl disulphide 81.36 µM 0.77522671562786 0.214049220637055 no 694 0.219102852236007 1020 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1825 st052143 62.6 µM 0.775090356511387 0.214090474396556 no 695 0.219143134773264 1046 674173
SGTC_1355 1499-0035 1.68 µM 0.772450813254073 0.214889946710284 no 696 0.219923734155905 1059 1548538
SGTC_1631 benzylvanillin 81.9 µM 0.770369223192447 0.215521645804786 no 697 0.22054045224826 1069 75506
SGTC_585 0kpi-0023 191 µM 0.770291999645818 0.21554510149595 no 698 0.220563350515926 1047 64601
SGTC_1725 st036284 20.55 µM 0.768517472762129 0.216084499695061 no 699 0.221089907054332 1119 707914
SGTC_2493 resveratrol 26.09 µM 0.767878969864968 0.216278774818496 no 700 0.221279546273224 1028 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.767367732712603 0.21643440009288 no 701 0.22143145384186 1110 4213774
SGTC_1036 k216-0215 33.5 µM 0.766586472062098 0.216672348138718 no 702 0.221663710571271 1076 622330
SGTC_2659 sanguinarine 24.21 µM 0.766413727477365 0.216724981262866 no 703 0.221715083655365 1053 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2251 lansoprazole 556 µM 0.765780987314852 0.216917832443004 no 704 0.221903314429401 914 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1025 k007-0731 70 µM 0.76562862947227 0.216964283996074 no 705 0.221948652247512 1102 6256118
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.764933424934787 0.217176314078344 no 706 0.222155594552377 1040 521171
SGTC_2341 7987486 176.74 µM 0.764926264954298 0.217178498419762 no 707 0.222157726444464 1119 1258686
SGTC_1583 clindamycin 39.6 µM 0.76303827344838 0.217754922917969 no 708 0.222720285321476 1015 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3079 9117512 49.47 µM 0.762507488403733 0.217917136209621 no 709 0.222878587757416 1138 7185044
SGTC_1142 3253-1408 9.78 µM 0.759918796058772 0.218709264815333 no 710 0.223651562803761 1094 256655
SGTC_3 0833-0587 95.581 µM 0.759780569174688 0.218751608196927 no 711 0.223692879724495 1061 5382644
SGTC_1040 k898-0338 155 µM 0.759115142719313 0.218955515932017 no 712 0.223891840770617 1149 20969351
SGTC_2988 9073640 71.4286 µM 0.757869234333389 0.219337595552628 no 713 0.224264634927614 1088 9102229
SGTC_443 clozapine 122 µM 0.757809347684121 0.219355970488087 no 714 0.224282562768618 1006 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1364 1653-0028 37.6 µM 0.756847946460703 0.219651076922964 no 715 0.224570481983967 1060 5718652
SGTC_1146 3579-1023 7 µM 0.756235407557179 0.219839217336388 no 716 0.224754033663825 1135 X1146
SGTC_1955 wogonin 32.4 µM 0.755951233012489 0.219926532525226 no 717 0.224839217487617 1086 5281703 A flavanone.
SGTC_104 0074-0074 590.992 µM 0.7540117158508 0.220522997818236 no 718 0.225421093403112 984 3943124
SGTC_1865 st057639 52.2 µM 0.75194273122975 0.22116029924021 no 719 0.226042749651508 1129 688818
SGTC_1160 4092-0570 10.5 µM 0.749786603872082 0.221825562729585 no 720 0.226691619081086 1095 4994975
SGTC_2496 diffractaic acid 79.83 µM 0.749379981111105 0.221951152356702 no 721 0.226814106679326 1111 94870 An apoptosis inducer which activates caspases.
SGTC_2697 mebhydrolin 72.4 µM 0.748363535858759 0.222265269475242 no 722 0.227120455308728 1118 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2367 9070478 135.38 µM 0.747573940662904 0.222509456950402 no 723 0.227358594000496 1087 572802
SGTC_703 3875-0075 71.8 µM 0.743916799102063 0.223642444980332 no 724 0.228463405784299 1173 2850814
SGTC_670 4204-0025 119 µM 0.742286369829704 0.224148609813409 no 725 0.228956924139044 1140 719039
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.742275963720543 0.22415184246576 no 726 0.228960075907956 1121 97141
SGTC_3278 9139605 49.47 µM 0.742212966328247 0.224171413137944 no 727 0.22897915687555 1141 7958859
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.742187545478905 0.224179310614351 no 728 0.228986856723134 1198 65057 A dermal irritant. YDR527W RBA50
SGTC_1065 prochlorperazine maleate 2.48 µM 0.742073621677178 0.224214705177919 no 729 0.229021365454808 1183 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2386 9075165 157.42 µM 0.741983540315124 0.224242694468709 no 730 0.229048654123339 1111 16452277
SGTC_2938 9059746 27.26 µM 0.740631325798882 0.224663081034917 no 731 0.229458504429948 1062 6471769
SGTC_1939 st074455 53.6 µM 0.738847991156913 0.225218180345256 no 732 0.229999653242628 1124 1644229
SGTC_1758 st042942 75.2445 µM 0.738313570540062 0.225384680834022 no 733 0.230161960936295 1123 669317
SGTC_2106 5357045 167.29 µM 0.737906554920222 0.22551153461699 no 734 0.230285617712503 1126 668842
SGTC_2133 5320837 200 µM 0.735013664191656 0.2264143198517 no 735 0.231165586197233 1092 2841355
SGTC_2975 9084847 53.72 µM 0.732613980748408 0.227164735910135 no 736 0.231896950795632 1112 27211724
SGTC_2820 7989630 71.43 µM 0.732200136402516 0.227294292667649 no 737 0.232023210551678 1037 2984098
SGTC_3128 9127691 49.47 µM 0.72987932379918 0.228021609615098 no 738 0.232731975880097 1044 41316314
SGTC_2912 7964298 10.93 µM 0.728708460171515 0.228389041516037 no 739 0.233090008302766 1186 2975850
SGTC_923 1900-2434 73.3 µM 0.727837036374835 0.228662721206205 no 740 0.23335667492593 1141 5910570
SGTC_1695 st026914 34.495 µM 0.726605584046703 0.229049785410879 no 741 0.233733803255558 1104 3289191
SGTC_3032 9089427 49.47 µM 0.725480329425453 0.229403791210281 no 742 0.234078704067254 1140 17173707
SGTC_2214 7179297 48.276 µM 0.724828668128886 0.229608944398193 no 743 0.234278573012504 1152 769744
SGTC_3244 9134489 49.47 µM 0.72465337293561 0.229664147608794 no 744 0.234332353357423 1141 16584271
SGTC_770 0389-1121 67.2 µM 0.722522279308639 0.230335856714701 no 745 0.234986716376444 1196 6753108
SGTC_1795 st049545 62.3 µM 0.721581801803909 0.230632639110291 no 746 0.235275815496291 1136 5291882
SGTC_1492 4158-0558 28.5 µM 0.721031013846498 0.230806548028651 no 747 0.235445216701463 1144 3967268
SGTC_2165 5727197 32.143 µM 0.720481523051495 0.230980120329792 no 748 0.235614286000375 1262 1361712
SGTC_1600 coumarin 106 71.1 µM 0.719370603207649 0.231331258448817 no 749 0.235956302271775 1177 100336 A hepatotoxic, DNA x-linker.
SGTC_2487 5918373 44.05 µM 0.718234782497418 0.231690574805566 no 750 0.236306267410721 1210 2876279
SGTC_761 k216-0224 480 µM 0.717555622067942 0.231905575383548 no 751 0.236515664431216 1212 1340404
SGTC_1092 toremifene 6.32 µM 0.717380262109438 0.231961106808995 no 752 0.236569747550511 1181 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2390 9097792 176.6 µM 0.714804782874166 0.23277753900406 no 753 0.237364839675415 1137 4497149
SGTC_1100 amiodarone 5.07 µM 0.71417449656586 0.232977583986465 no 754 0.237559642503664 1190 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2800 7887935 81.82 µM 0.713967837260065 0.233043195842153 no 755 0.23762353386883 1140 2961002
SGTC_1647 st011722 22.4 µM 0.713115603330073 0.233313878288921 no 756 0.237887112468245 1150 2854783
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.712881356967171 0.233388309049064 no 757 0.237959588176253 1113 6857784
SGTC_558 k064-0027 21.3 µM 0.71239663462862 0.233542369284129 no 758 0.23810959946086 1168 5088526
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.712101212304172 0.23363629158528 no 759 0.23820105181724 1280 5282309
SGTC_2220 6782180 200 µM 0.711809125615322 0.233729173988491 no 760 0.238291490494489 1115 833803
SGTC_501 nsc-95397 161 µM 0.711791758046361 0.233734697450859 no 761 0.238296868599838 1170 262093
SGTC_3088 9117578 49.47 µM 0.710017580948758 0.234299325620317 no 762 0.238846616970029 1230 678341
SGTC_51 1013-0126 23.419 µM 0.709984502441745 0.234309859950502 no 763 0.23885687329375 1220 1627850
SGTC_2359 9039622 200 µM 0.709810799367737 0.234365182515591 no 764 0.238910735631956 1155 6463596
SGTC_718 1130-0073 349 µM 0.709380378674486 0.23450229803068 no 765 0.239044230308342 1217 6740020
SGTC_3223 9129970 49.47 µM 0.709055910448066 0.234605690485452 no 766 0.239144890850985 1207 17248386
SGTC_1228 0124-0032 52.5 µM 0.707823324487257 0.234998686195414 no 767 0.239527489963744 1213 X1228
SGTC_228 caffeine 993.056 µM 0.707717579222689 0.235032418776401 no 768 0.239560329231852 1168 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_5 0352-0601 109.883 µM 0.707503250531695 0.235100797512517 no 769 0.239626896700011 1105 762456
SGTC_172 1112-0046 2.638 µM 0.707032029864308 0.235251172867942 no 770 0.239773286685973 1094 2802135 YIL048W NEO1
SGTC_1627 st003713 25.6 µM 0.706990242994221 0.235264510405134 no 771 0.239786270600804 1223 16195070 YER133W GLC7
SGTC_219 mitoxanthrone 164.414 µM 0.705658274420668 0.235689866938876 no 772 0.240200337564137 1147 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1581 himbacine 57.9 µM 0.705164159998539 0.235847767334614 no 773 0.240354041165765 1173 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_907 3448-6986 75.5 µM 0.704316513127782 0.236118779191282 no 774 0.240617842448765 1215 590582
SGTC_2462 5162487 171.77 µM 0.704244975830996 0.236141659129004 no 775 0.240640113211502 1163 2259986
SGTC_2337 9009472 200 µM 0.703611999223626 0.236344158690514 no 776 0.24083721834656 1199 5742383
SGTC_2428 5615643 7.78 µM 0.702355198165802 0.236746513108537 no 777 0.241228838898836 1186 2253075
SGTC_1454 4239-0054 42.6 µM 0.701632003305151 0.236978208582915 no 778 0.241454343970775 1244 1340767
SGTC_726 3448-4391 34.2 µM 0.701094941752177 0.237150351717741 no 779 0.241621883415112 1255 1356692
SGTC_2007 4011539 71.82 µM 0.699342020857056 0.237712689279528 no 780 0.242169156106115 1204 45595301
SGTC_2449 5812982 45.77 µM 0.69893673509577 0.237842809114257 no 781 0.242295784394296 1141 776185
SGTC_1923 st058458 19.1 µM 0.698656575998542 0.237932778984092 no 782 0.242383338830539 1231 3534982
SGTC_2729 fluphenazine 10.66 µM 0.697411790349891 0.238332753115013 no 783 0.242772562513012 1147 3372 An atypical antipsychotic.
SGTC_3335 9143315 29.6265 µM 0.696325336569305 0.238682152854721 no 784 0.243112554756198 1174 4899691
SGTC_1521 st012942 49.4 µM 0.694540554641086 0.239256740394753 no 785 0.24367163858558 1240 24207259
SGTC_2167 5876490 200 µM 0.693887216406152 0.239467263021506 no 786 0.243876470551408 1213 686534
SGTC_2736 butenafine 14.65 µM 0.693713554415028 0.239523238458108 no 787 0.243930931984908 1191 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2036 5160441 105 µM 0.692331648425314 0.239968914486125 no 788 0.244364539698496 1217 134534 YIL048W NEO1
SGTC_2309 7664088 163.95 µM 0.69051406221798 0.240555788854601 no 789 0.244935484909659 1221 704922
SGTC_1646 st011709 75.6 µM 0.68961479984289 0.240846437401269 no 790 0.245218228892439 1188 5757843
SGTC_1131 3454-3128 32.3 µM 0.689287419134512 0.240952296794126 no 791 0.245321206729175 1245 710982
SGTC_3059 1327-0034 3 µM 0.689028482074003 0.241036042678008 no 792 0.24540267202793 1175 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_159 3970-0959 50 µM 0.687890257601083 0.241404356890178 no 793 0.245760946055523 1302 6615653
SGTC_3105 9121040 49.47 µM 0.68787134379104 0.241410479727407 no 794 0.245766901845276 1069 41448907
SGTC_3216 9129716 49.47 µM 0.685785511833767 0.242086229090518 no 795 0.246424186902425 1171 8056934
SGTC_68 0986-0284 82.829 µM 0.684221963711614 0.242593445386819 no 796 0.246917507522309 1177 423278 YIL048W NEO1
SGTC_2453 5731132 22.18 µM 0.683780022705944 0.242736915658656 no 797 0.247057041645905 1257 1362040
SGTC_1056 3448-1962 115 µM 0.682666564476314 0.243098588608125 no 798 0.247408780981752 1197 715507
SGTC_2331 7980721 200 µM 0.682607700440219 0.243117716901912 no 799 0.247427383464464 1201 2981221
SGTC_47 0149-0135 24.25 µM 0.682435030712029 0.243173831872501 no 800 0.247481955656146 1177 5239155
SGTC_1500 4488-1866 171 µM 0.682399170248949 0.243185486842242 no 801 0.247493290146252 1270 2900003
SGTC_893 0958-0369 48.9 µM 0.682289944495102 0.243220988045356 no 802 0.247527815063266 1225 6819948
SGTC_1368 1852-0141 284 µM 0.681886069578692 0.243352282198072 no 803 0.24765549730049 1204 2838987
SGTC_108 0509-0257 621.132 µM 0.681040388557312 0.243627325427417 no 804 0.247922967359134 1215 536624
SGTC_1175 0741-0056 27.6 µM 0.680433864584985 0.243824690255834 no 805 0.248114892267662 1268 765927
SGTC_2181 6316240 54.2555 µM 0.680384041417869 0.243840906707328 no 806 0.248130661541835 1206 12779990
SGTC_410 α-linolenic acid 100 µM 0.679852758077237 0.24401386507514 no 807 0.248298848535634 1264 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2768 sulfasalazine 50.2 µM 0.678782326460056 0.244362543124615 no 808 0.248637896812247 1263 5384001 An antioxidant and salicylic acid derivative.
SGTC_797 k781-0471 270 µM 0.678679928703328 0.244395911819981 no 809 0.248670343173413 1212 23738129
SGTC_3183 9108214 49.47 µM 0.677664408195641 0.244726975732989 no 810 0.248992249075741 1138 4974831
SGTC_876 0720-0963 56.8 µM 0.67712780977138 0.244902006502262 no 811 0.249162432822654 1241 765861
SGTC_2259 7964009 200 µM 0.676976687016587 0.244951312749069 no 812 0.249210373005591 1233 313134
SGTC_406 estrone 100 µM 0.675772967584048 0.245344236350833 no 813 0.249592400106089 1247 5870 A steroid.
SGTC_3157 9099274 49.47 µM 0.675220101459847 0.24552481890546 no 814 0.249767968654864 1214 17217662
SGTC_477 mead ethanolamide 10 µM 0.675016322860308 0.245591397075209 no 815 0.249832697263262 1112 16061185
SGTC_853 0419-0306 21 µM 0.673413170246372 0.246115514215769 no 816 0.250342236061517 1184 762713
SGTC_254 nsc-64875 3.808 µM 0.671835962691518 0.246631734028698 no 817 0.250844065700924 1242 56993
SGTC_3084 9116877 49.47 µM 0.670911718837624 0.246934508186872 no 818 0.251138385220412 1164 27241325
SGTC_1920 st075728 45.7 µM 0.66890796969598 0.247591601283951 no 819 0.25177709300611 1267 3400306
SGTC_1427 4048-4900 550 nM 0.66872632646659 0.247651214017814 no 820 0.251835035310432 1230 24132586
SGTC_1283 0922-0125 16.4 µM 0.66661741259887 0.248343890478244 no 821 0.252508271918964 1238 3360884
SGTC_2034 5197015 53.07 µM 0.666243969455126 0.248466656079552 no 822 0.252627586351425 1261 780676
SGTC_1874 staurosporine 7.6 µM 0.665997602731712 0.248547664313599 no 823 0.252706316344247 1258 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_955 1216-0110 33 µM 0.665237992936549 0.248797521369033 no 824 0.252949141776897 1208 3619719
SGTC_2152 5568786 200 µM 0.664815750800823 0.248936466505021 no 825 0.253084173538692 1219 5399883
SGTC_2260 7964312 200 µM 0.663867362354675 0.249248698496865 no 826 0.253387603485355 1281 231951
SGTC_2328 6201408 200 µM 0.663510285430809 0.249366310637162 no 827 0.253501897164411 1215 2890418
SGTC_3276 9139060 49.47 µM 0.663289661575836 0.249438993317112 no 828 0.253572528291503 1295 4870619
SGTC_2064 5220758 200 µM 0.663261313535311 0.249448333157678 no 829 0.253581604460537 1289 788518
SGTC_587 k089-0003 57 µM 0.661778534510161 0.249937123968794 no 830 0.254056582426862 1201 9659696
SGTC_787 4152-0075 138 µM 0.660638016269587 0.250313435772708 no 831 0.254422241454118 1269 9566539
SGTC_7 0192-1582 4.227 µM 0.660239676607864 0.250444937921737 no 832 0.254550017206231 1289 252616
SGTC_2384 9036245 200 µM 0.660074936465742 0.250499333572211 no 833 0.254602870866504 1251 6462766
SGTC_3126 9127922 49.47 µM 0.65988729863981 0.250561297448518 no 834 0.254663077803323 1287 45595682
SGTC_2066 5222451 176 µM 0.659340581597678 0.250741886797996 no 835 0.2548385442018 1257 2281147
SGTC_2823 7987624 58.44 µM 0.658475349035191 0.251027827689367 no 836 0.255116366008458 1287 2239440
SGTC_1219 1469-0211 33.1 µM 0.657507559449396 0.251347865792467 no 837 0.255427305944348 1233 6822282
SGTC_1089 terbinafine 2.25 µM 0.656915523682745 0.251543752237255 no 838 0.255617617977152 1252 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2460 5552655 174.22 µM 0.656535793508371 0.251669435729865 no 839 0.255739722582851 1241 5401989
SGTC_2408 sulbentine 18.36 µM 0.656197316797281 0.251781493059463 no 840 0.255848587544082 1252 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3330 9141424 71.43 µM 0.654931721553647 0.252200718911506 no 841 0.256255857744456 1265 27261020
SGTC_1421 4029-0249 71.4 µM 0.653999618485676 0.252509711391739 no 842 0.256556025704861 1344 2894095
SGTC_780 0109-0199 192 µM 0.651685888382802 0.253277574972722 no 843 0.257301913941981 1291 610414
SGTC_462 ag-879 158 µM 0.649998252013345 0.253838428547126 no 844 0.25784667535756 1269 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_936 3005-4620 401 µM 0.648292631697521 0.254405920434699 no 845 0.258397849407547 1308 777207
SGTC_1680 diphenhydramine 100 µM 0.647341051052066 0.254722817890877 no 846 0.258705619347045 1286 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_257 daunorubicin 18.5 µM 0.645735685257317 0.255257908413404 no 847 0.259225272924647 1310 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_321 4534-3890 65.3 µM 0.645515958194757 0.255331192163377 no 848 0.259296440069712 1292 699746
SGTC_1486 3970-0793 4.53 µM 0.644953548953533 0.255518817953182 no 849 0.259478644133326 1294 2844330
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.644269280942326 0.255747194234161 no 850 0.259700415991456 1315 688788
SGTC_1305 1181-0477 144 µM 0.643695423759047 0.255938802733337 no 851 0.259886479001391 1303 6252086
SGTC_2746 daunorubicin 9.88 µM 0.643135187175945 0.256125935605997 no 852 0.260068192087971 1176 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1803 st050068 52.4 µM 0.643028737670309 0.256161500438667 no 853 0.260102726456194 1358 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_317 4495-0002 170 µM 0.642892614249363 0.256206983092912 no 854 0.260146891085735 1238 15991618
SGTC_1169 aniline yellow 25.8 µM 0.642247652696446 0.256422540067247 no 855 0.260356198483802 1254 6051 A DNA damaging agent.
SGTC_2205 7238770 200 µM 0.641444320727802 0.256691159186829 no 856 0.260617022615343 1306 279867
SGTC_2946 9065502 71.43 µM 0.640581538693291 0.256979820384682 no 857 0.260897298593068 1123 16489101
SGTC_22 0964-0034 14.468 µM 0.638938784407932 0.257529903606107 no 858 0.261431377942651 1254 138402
SGTC_1973 st070275 50.2 µM 0.638534581196587 0.257665346456075 no 859 0.261562875323992 1243 17118334
SGTC_2285 7945142 200 µM 0.635762622775289 0.258595186532419 no 860 0.262465576402236 1277 2970608
SGTC_1928 4'-methoxychalcone 40.3 µM 0.635377051333823 0.258724662123746 no 861 0.262591265760425 1342 641818
SGTC_960 1222-0186 7.7 µM 0.635334318765993 0.258739013862977 no 862 0.262605197705158 1311 3126296
SGTC_2763 lisinopril 49.32 µM 0.63442324101187 0.259045097476942 no 863 0.26290232307116 1257 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_657 3534-0529 86.7 µM 0.632720152471101 0.259617764987028 no 864 0.263458203668035 1342 1049549
SGTC_473 2-arachidonoylglycerol 10 µM 0.630857843473141 0.260244718002687 no 865 0.264066739078974 1257 5282280 An endocannabinoid.
SGTC_3205 9113483 49.47 µM 0.630205712127192 0.260464444656372 no 866 0.264280001256072 1302 17018033
SGTC_2651 TUB2.036 5 µM 0.629909038017298 0.260564436510257 no 867 0.264377049632468 1372 15992207 YFL037W TUB2
SGTC_1843 st055809 45.5 µM 0.628971100264314 0.260880691571663 no 868 0.26468398820243 1300 16413835
SGTC_1405 3909-7894 12 µM 0.628770131283959 0.260948480226393 no 869 0.264749778535233 1328 7104060
SGTC_1703 st026983 48.3 µM 0.624721199660678 0.262316148509908 no 870 0.266077028408559 1326 1104023
SGTC_2429 5902844 64.44 µM 0.624389888164514 0.262428222836357 no 871 0.266185782104946 1325 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_865 0488-0499 301 µM 0.623543860995833 0.262714523692459 no 872 0.266463594373239 1311 9634651
SGTC_3070 9117005 49.47 µM 0.622606144855943 0.263032039262406 no 873 0.266771686082266 1355 8779016
SGTC_2218 6965428 192.983 µM 0.622292791358197 0.263138186092753 no 874 0.266874680185162 1297 675684
SGTC_1755 st041960 45.185 µM 0.622068648004124 0.263214126885894 no 875 0.266948364714432 1324 2257073
SGTC_2232 chlorophetanol 41.5365 µM 0.621550011964273 0.263389886058015 no 876 0.267118899688756 1367 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1451 4152-0210 104 µM 0.620555593987556 0.263727049192028 no 877 0.267446032345723 1346 659563
SGTC_996 3970-0799 1.8 µM 0.619007028443489 0.264252537202577 no 878 0.267955864363405 1403 6615648 YGL040C HEM2
SGTC_2284 7945075 39.21 µM 0.619004823675707 0.264253285745244 no 879 0.267956590584688 1362 1245402
SGTC_378 3970-0959 8.33 µM 0.617998288998906 0.264595127955705 no 880 0.268288233240217 1326 6615653
SGTC_1070 indatraline 8.81 µM 0.617780588677309 0.26466909354526 no 881 0.268359990370878 1293 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_356 1634-0012 32.5 µM 0.617596397145519 0.264731682441772 no 882 0.268420710063973 1321 735457
SGTC_3080 9117754 49.47 µM 0.617237993507979 0.264853490759342 no 883 0.268538879476874 1428 9550191
SGTC_1050 3232-1156 69.3 µM 0.617124354075404 0.264892118603307 no 884 0.26857635304107 1288 700529
SGTC_908 3448-7491 47.7 µM 0.615213110889422 0.265542209207847 no 885 0.26920699520682 1319 1203031
SGTC_3066 9117245 49.47 µM 0.614873445039997 0.265657827849132 no 886 0.269319150525604 1389 17176980
SGTC_1995 st072814 61.1 µM 0.614767831851982 0.265693782656546 no 887 0.269354028046028 1259 5769371
SGTC_2747 doxorubicin 7.63 µM 0.614531206704702 0.265774347949583 no 888 0.269432178954499 1227 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2765 myclobutanil 7.74 µM 0.612924090234832 0.266321860750611 no 889 0.269963266791775 1334 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3300 9124615 50.48 µM 0.611447520848041 0.26682540138761 no 890 0.270451675403168 1383 24824903
SGTC_389 tpck 16.7 µM 0.610132850645929 0.267274135546971 no 891 0.270886903481823 1309 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2110 5483698 200 µM 0.609910382793214 0.267350107778403 no 892 0.270960587128786 1330 2848765 YHR062C RPP1
SGTC_549 1661-1316 519 µM 0.609099584811427 0.267627085496363 no 893 0.271229216388511 1361 2857282
SGTC_1819 st053448 58.6 µM 0.608990535030572 0.267664349161375 no 894 0.27126535630618 1317 2857616
SGTC_3292 9120825 59.784 µM 0.608887908389883 0.267699420347972 no 895 0.271299369739135 1339 24824900
SGTC_571 k831-0106 44.2 µM 0.60725735623412 0.268256948734603 no 896 0.271840066830075 1365 4783639
SGTC_2667 digitoxin 100 µM 0.607041082457784 0.268330942246235 no 897 0.271911824264607 1300 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2982 9019404 25.97 µM 0.606668435312546 0.268458459686613 no 898 0.272035486889987 1188 22333232
SGTC_198 3454-2873 16.191 µM 0.606135565211753 0.268640857305051 no 899 0.272212367935516 1304 710957
SGTC_1694 st024011 44.9 µM 0.604351610333416 0.26925194515083 no 900 0.272804950079423 1376 2787533
SGTC_2960 9079389 5.97 µM 0.603696150382669 0.269476645806127 no 901 0.273022837004406 1366 16457355
SGTC_535 2293-4129 48.2 µM 0.602028519132564 0.270048756092621 no 902 0.273577576918747 1367 396118 YIL048W NEO1
SGTC_1125 tnp00248 1.32998 µM 0.601768451428235 0.270138031647449 no 903 0.273664139061566 1432 24207736
SGTC_1715 st032160 10.2275 µM 0.60043644214003 0.270595512615604 no 904 0.274107703536192 1302 5289825
SGTC_2265 7929201 200 µM 0.597924589460514 0.271459264520169 no 905 0.274945125877168 1314 1265108
SGTC_1641 st009299 47.1 µM 0.597586326898606 0.271575687867839 no 906 0.275057994901995 1290 4046054
SGTC_1816 st051957 91.6 µM 0.597333834532735 0.271662606998166 no 907 0.275142259616356 1350 674121
SGTC_3102 9121669 49.47 µM 0.596863635198091 0.271824507474998 no 908 0.275299213924543 1395 41905072
SGTC_2596 sinensetin 100 µM 0.596236176142964 0.272040630856547 no 909 0.275508730735491 1334 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1426 4048-4480 71.7 µM 0.596217509117511 0.272047061876591 no 910 0.275514965101339 1377 14224343
SGTC_2704 st078022 71.1 µM 0.595138465322737 0.272418934177919 no 911 0.275875459297074 1410 54697681
SGTC_2096 5468907 200 µM 0.593909726899182 0.272842703148368 no 912 0.276286246458846 1365 759785
SGTC_367 0335-0881 7.1 µM 0.593189218936061 0.273091344897771 no 913 0.27652726344958 1375 23828853
SGTC_2913 7966556 36.57 µM 0.593067473602643 0.273133369363236 no 914 0.27656799863725 1353 2976516
SGTC_2314 7727897 200 µM 0.592298429823496 0.273398904529629 no 915 0.276825383583104 1330 900724
SGTC_2115 tiliquinol 12.7705 µM 0.591148075173002 0.273796337028289 no 916 0.277210605198366 1371 71208 A bioactive hydroxyquinoline.
SGTC_3015 9080845 49.47 µM 0.590957176929058 0.27386231750645 no 917 0.277274557044391 1422 5296973
SGTC_424 splitomicin 100 mM 0.590826000469049 0.273907660801494 no 918 0.277318505982886 1313 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_266 formosanin C 406 nM 0.588853684491268 0.274589871242432 no 919 0.277979714730443 1336 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2442 5158906 48.48 µM 0.588279342185795 0.274788689729991 no 920 0.278172404552616 1428 1893835
SGTC_3355 9151058 44.0485 µM 0.588043456693266 0.27487036611238 no 921 0.278251562171106 1341 17015728
SGTC_2856 9022925 19.48 µM 0.587877317106388 0.27492789985067 no 922 0.278307321296301 1377 4944862
SGTC_53 0973-0023 39.979 µM 0.587691665892324 0.274992197438016 no 923 0.278369635281478 1346 674768
SGTC_3271 9137798 49.47 µM 0.585997790760056 0.275579188282573 no 924 0.278938499731918 1326 6498326
SGTC_142 0335-0849 62.6745 µM 0.584595976957809 0.276065434490092 no 925 0.279409706710257 1394 3889043 YPR107C YTH1
SGTC_1315 1237-0019 3.69 µM 0.583194779215962 0.276551887595727 no 926 0.279881092660784 1386 825140
SGTC_65 0798-0905 34.986 µM 0.582298229766711 0.276863362506575 no 927 0.280182908838825 1562 3602145
SGTC_2808 7946468 45.46 µM 0.582233812478917 0.276885748665645 no 928 0.280204600472648 1399 2970879
SGTC_152 4469-0003 551.229 µM 0.580533825155538 0.277476844795265 no 929 0.2807773416332 1362 697280
SGTC_1502 4534-4282 27.7 µM 0.580148495352128 0.27761091205062 no 930 0.28090724140038 1361 3278949
SGTC_3024 9090631 49.47 µM 0.579745392228894 0.277751197014311 no 931 0.281043163870649 1330 25236383
SGTC_224 benfluorex 43.875 µM 0.577995357646043 0.278360632169288 no 932 0.281633626740686 1381 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2451 5856223 45.7 µM 0.577994971660921 0.278360766657289 no 933 0.281633757038289 1339 2179896
SGTC_1946 st076057 65.1 µM 0.577919507327186 0.278387061148132 no 934 0.281659232210143 1280 953009
SGTC_1974 st069448 26.9 µM 0.577857927606329 0.278408518636811 no 935 0.281680021051952 1370 6323587 YNR016C ACC1
SGTC_1623 st003709 20.3 µM 0.577107561254094 0.27867004894378 no 936 0.28193339839397 1342 16192618
SGTC_1654 st012436 41.8 µM 0.576750057715774 0.27879469415047 no 937 0.282054155760498 1369 4323132
SGTC_1659 st012954 42.1 µM 0.576679174401053 0.278819411158013 no 938 0.282078101649572 1369 24207262
SGTC_1005 4092-0690 4.4 µM 0.575809242001168 0.279122843359878 no 939 0.282372062988762 1349 1529343
SGTC_2861 9024595 19.48 µM 0.575404493739307 0.279264074156167 no 940 0.282508882842901 1330 16482810
SGTC_1624 st003710 6.25 µM 0.574294392790245 0.279651605267291 no 941 0.282884301464076 1430 24207033
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.573339824158744 0.279985049345689 no 942 0.283207312971088 1337 61125 An anti-inflammatory.
SGTC_669 0108-0021 26.2 µM 0.572105366741903 0.28041654807941 no 943 0.283625296761307 1599 17201
SGTC_1080 nisoldipine 24.4 µM 0.571755552021623 0.280538882673473 no 944 0.283743796751981 1356 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3092 9117248 49.47 µM 0.568438981487908 0.281700010450883 no 945 0.284868463747581 1441 17141857
SGTC_110 0850-0284 111.64 µM 0.567545864578166 0.28201308522863 no 946 0.285171687575329 1264 3906265
SGTC_2327 6189656 200 µM 0.565510262583994 0.282727274327424 no 947 0.285863372956335 1473 5349088
SGTC_1496 4469-0713 57.4 µM 0.564007296124779 0.283255145816245 no 948 0.286374583351087 1421 746691
SGTC_808 0711-0032 135 µM 0.563905940859753 0.283290760793576 no 949 0.28640907336234 1390 4252555
SGTC_1736 st036774 51 µM 0.562436212003209 0.28380744641402 no 950 0.286909426330707 1442 1272247
SGTC_1357 1503-1303 39.5 µM 0.562412887417747 0.283815649846323 no 951 0.286917370265784 1405 292895
SGTC_2073 5212005 126 µM 0.562260469744942 0.283869259083785 no 952 0.286969283554183 1296 691789
SGTC_297 0986-0032 24 µM 0.562121090439848 0.283918286632526 no 953 0.287016759883655 1359 2847425
SGTC_1985 st071382 65.5 µM 0.561727736771327 0.28405667311649 no 954 0.287150766753504 1403 6123237
SGTC_2750 bromebric acid 70.15 µM 0.559768960510248 0.284746273799233 no 955 0.287818518990868 1447 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_757 1066-0008 322 µM 0.555778049435532 0.286153768741385 no 956 0.289181296512697 1456 6842497
SGTC_1922 5578187 25 µM 0.555528975057531 0.286241720521368 no 957 0.28926644848852 1488 1350412
SGTC_76 0433-0009 400.328 µM 0.555398665422652 0.286287739860149 no 958 0.289311002618933 1410 2841569
SGTC_691 1548-0686 185 µM 0.553856200800703 0.286832733763869 no 959 0.289838631111433 1363 46495133
SGTC_123 0083-0120 66.675 µM 0.553341694836736 0.287014631743729 no 960 0.290014727711522 1338 16001701
SGTC_290 2043-6722 48.1 µM 0.553153659243058 0.287081123309637 no 961 0.290079097940462 1425 773758 YLR208W SEC13
SGTC_2670 beta-carotene 100 µM 0.552741822001023 0.287226779210514 no 962 0.290220105582485 1354 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2567 aureobasidin a 60 nM 0.551907826864554 0.28752184823891 no 963 0.290505752833521 1493 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2207 7258803 200 µM 0.549190475917298 0.288484244982281 no 964 0.291437369880653 1414 3666799
SGTC_952 1185-0122 232 µM 0.547248555695606 0.289172938332253 no 965 0.292103990838741 1349 678600
SGTC_38 0929-0051 58.268 µM 0.54712517046291 0.289216722460003 no 966 0.292146370398671 1475 1379719
SGTC_2546 rhodinyl acetate 100 µM 0.546689500506212 0.289371347968297 no 967 0.292296034374658 1423 6708682
SGTC_2100 5377183 190 µM 0.54424657681712 0.29023909526109 no 968 0.293135902121941 1479 2844202
SGTC_1111 tnp00062 510.699 nM 0.543324639035654 0.290566891929859 no 969 0.293453151386145 1521 676306
SGTC_1197 1601-0112 267 µM 0.543188187909906 0.290615422090559 no 970 0.293500119277155 1390 7350313
SGTC_1114 scopoletin 1.73284 µM 0.542436439993689 0.290882856466165 no 971 0.293758941103566 1460 5280460 A coumarin with genotoxic properties.
SGTC_1933 st074711 15.9 µM 0.541249117747822 0.291305480591905 no 972 0.294167943274448 1381 17250958
SGTC_807 1315-0151 48 µM 0.54093597764072 0.291416989700253 no 973 0.294275855870994 1493 4011080
SGTC_3270 9137563 49.47 µM 0.540373215123472 0.291617439319147 no 974 0.294469837892806 1448 17015724
SGTC_1963 st076565 50.3 µM 0.539990266959362 0.291753877849597 no 975 0.294601872352138 1436 4914280
SGTC_2348 9022543 33.42 µM 0.538854379652108 0.292158751866352 no 976 0.294993668863068 1454 3162678 YDL140C RPO21
SGTC_2089 5281248 129.67 µM 0.538461724667435 0.292298770021457 no 977 0.295129161396957 1422 2737878
SGTC_2602 kawain 100 µM 0.538014775497122 0.292458187093329 no 978 0.295283423963657 1393 5369129
SGTC_1809 st050081 57.6 µM 0.537840127699207 0.292520491153569 no 979 0.295343712975175 1497 5036894
SGTC_715 0868-0130 184 µM 0.53766797434168 0.292581911380524 no 980 0.295403146440041 1567 2876258
SGTC_2404 5161160 200 µM 0.537659892822209 0.292584794821868 no 981 0.295405936603335 1450 2831543
SGTC_1632 st005650 90 µM 0.537652795312918 0.292587327184726 no 982 0.295408387044836 1436 2759605
SGTC_1033 k072-0102 21.3 µM 0.537070144586075 0.292795249351878 no 983 0.295609581261287 1494 5965931
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.536500045955479 0.292998758609973 no 984 0.295806502081462 1482 688798
SGTC_1677 st019204 53.9 µM 0.535757173732472 0.293264041636847 no 985 0.296063191935568 1379 3945625
SGTC_2686 alizarin 95.37 µM 0.535755274047555 0.29326472016561 no 986 0.296063848478062 1398 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2829 7992743 58.44 µM 0.533078995823407 0.294221354031248 no 987 0.296989449058099 1484 16462845
SGTC_2748 diazoxide 86.69 µM 0.532493853112248 0.294430704801252 no 988 0.29719199901112 1446 3019 A potassium channel activatior.
SGTC_2160 5660466 132.927 µM 0.531431380316037 0.294811009114634 no 989 0.297559940385668 1429 2859134
SGTC_2921 7974240 10.71 µM 0.530904003542073 0.294999863809653 no 990 0.297742651653274 1485 2979074 YDR527W RBA50
SGTC_372 0155-0182 15.9 µM 0.530506768574434 0.295142151249983 no 991 0.297880308686092 1447 771486
SGTC_3208 9114115 49.47 µM 0.529952761491116 0.295340646376256 no 992 0.298072341666105 1364 650895
SGTC_2927 9011802 47.9 µM 0.529426408804962 0.295529290096276 no 993 0.298254841164451 1378 43912568
SGTC_112 phenothiazine 287.218 µM 0.528985217828822 0.295687454706378 no 994 0.298407852177377 1477 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_517 1365-0151 113 µM 0.528452716116273 0.29587840552311 no 995 0.29859257855658 1456 768657
SGTC_1170 0310-0127 64.8 µM 0.526585226738673 0.296548519284881 no 996 0.299240826633777 1484 774975
SGTC_2411 st077133 39.94 µM 0.526066963221265 0.296734611678325 no 997 0.299420840829579 1593 1403142 YNL221C POP1
SGTC_2310 7668677 200 µM 0.523260949808358 0.297743091392396 no 998 0.300396335928746 1499 2197143
SGTC_1012 4112-3522 18 µM 0.521743951226032 0.298288950207746 no 999 0.300924309398894 1486 3112398
SGTC_3164 9100705 49.47 µM 0.52097113590404 0.298567205994749 no 1000 0.301193439447234 1515 17174235
SGTC_1293 1000-1278 195 µM 0.519566596859716 0.299073218897453 no 1001 0.301682842312572 1509 678847
SGTC_2278 7948257 134.34 µM 0.518342089483005 0.299514689261244 no 1002 0.302109805807087 1471 1247028
SGTC_847 0342-0274 5.54 µM 0.517480098083269 0.299825639161541 no 1003 0.302410529171519 1523 18097
SGTC_3190 9110366 49.47 µM 0.516914259439586 0.300029836020835 no 1004 0.302608006532908 1496 17123768
SGTC_688 0527-0193 473 µM 0.516683333740965 0.300113189340984 no 1005 0.302688616070497 1488 4007154
SGTC_2762 leflunomide 42.06 µM 0.513120582998056 0.301400499808752 no 1006 0.303933487172287 1490 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_271 rotenone 740 µM 0.512380324061321 0.301668285351092 no 1007 0.304192429399449 1492 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_905 2-aminofluorene 215 µM 0.51205607748594 0.301785613866097 no 1008 0.304305881642516 1470 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2769 toremifene 3.73 µM 0.509715339412164 0.30263321695507 no 1009 0.305125452426702 1484 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_838 0109-0203 71.4 µM 0.509094838036843 0.302858085034473 no 1010 0.305342874935101 1453 759422
SGTC_1032 k061-1018 98.7 µM 0.508364615663494 0.303122811491821 no 1011 0.305598831456461 1619 4005393
SGTC_456 gingerol 170 µM 0.507758862179784 0.303342492929554 no 1012 0.305811231437676 1518 442793 A herb.
SGTC_1561 5-methoxyflavone 52.9 µM 0.507543011249808 0.303420790219218 no 1013 0.305886932694198 1453 94525
SGTC_3106 9121286 49.47 µM 0.507239268375663 0.30353098452857 no 1014 0.30599347265295 1505 15943471
SGTC_2948 9070189 9.45 µM 0.506944345451781 0.303637996163009 no 1015 0.306096934659725 1527 6473636 YDL196W YDL196W
SGTC_1222 0366-0074 1.18 µM 0.506310250318899 0.303868132125777 no 1016 0.306319434156497 1559 286520
SGTC_863 0466-0191 129 µM 0.506137775490868 0.303930742909454 no 1017 0.306379966715863 1487 765160 YPR165W RHO1
SGTC_1179 1021-1431 9.29 µM 0.50568474854751 0.304095225442238 no 1018 0.306538988302695 1486 2840958
SGTC_2572 astragaloside iv 100 µM 0.505560895441078 0.304140200251704 no 1019 0.306582469582018 1497 45006101 An anti-inflammatory agent.
SGTC_569 4130-2812 160 µM 0.505246984951734 0.30425420391937 no 1020 0.306692686760796 1453 743552
SGTC_2532 xanthone 78.9 µM 0.505163999353532 0.304284345189834 no 1021 0.306721826773858 1524 7020 An insecticide.
SGTC_1061 3448-9325 110 µM 0.504918696504231 0.304373449622523 no 1022 0.306807970888909 1460 723482
SGTC_222 nsc-310342 10.666 µM 0.502919611678494 0.30510003491291 no 1023 0.307510396043005 1511 432556
SGTC_1152 3909-8331 15.9 µM 0.502873969351038 0.305116633014139 no 1024 0.307526441799078 1460 16001939
SGTC_2752 diclazuril 33.15 µM 0.502530912035681 0.305241400655021 no 1025 0.307647056855754 1506 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3329 9141233 27.5565 µM 0.502403739376596 0.305287658247851 no 1026 0.30769177460256 1565 4909101 YNL103W MET4
SGTC_2273 7815444 169.05 µM 0.501313639672998 0.305684296998035 no 1027 0.308075203730275 1591 2824616
SGTC_1373 2887-0003 58.5 µM 0.499522337954674 0.306336567185566 no 1028 0.308705727047157 1487 776948
SGTC_3293 9120939 62.045 µM 0.498557585138198 0.306688119135731 no 1029 0.309045545976795 1538 934087
SGTC_1568 digitonin 820 nM 0.49556567293362 0.307779489940994 no 1030 0.310100438376292 1632 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3328 9140624 29.0385 µM 0.494486340370178 0.308173620537656 no 1031 0.310481375445494 1593 4904392
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.494456786844905 0.308184415458974 no 1032 0.31049180885843 1431 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1462 k081-0014 26.5 µM 0.494378741168037 0.308212923750449 no 1033 0.310519362405018 1354 3270634
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.494104445202225 0.308313126938032 no 1034 0.310616209343539 1562 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1271 0832-2808 169 µM 0.493072527218301 0.308690225283356 no 1035 0.310980670910815 1579 3663794
SGTC_355 1311-2252 105 µM 0.490743903687139 0.30954192562344 no 1036 0.311803795079172 1461 5338538
SGTC_2545 solidagenone 89.61 µM 0.489459808961199 0.310012025045388 no 1037 0.312258100977236 1426 6708572 An anti ulcer agent
SGTC_2164 5685496 200 µM 0.488823425441794 0.310245116472692 no 1038 0.312483355976977 1529 759046
SGTC_427 1354-0053 47.3 µM 0.488520708920952 0.310356020760355 no 1039 0.312590530446418 1573 6813657
SGTC_404 fumagillin 50 µM 0.487060876207996 0.310891092173994 no 1040 0.313107595449778 1514 12015870 A methionine aminopeptidase binder.
SGTC_1827 berberine 7.24 µM 0.487052009099074 0.310894343452505 no 1041 0.313110737257312 1382 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3323 9138564 53.9225 µM 0.487017833824053 0.310906874544969 no 1042 0.313122846419714 1613 43912313 YNL103W MET4
SGTC_2551 apiole 73.87 µM 0.486554816010684 0.311076671493938 no 1043 0.313286925174401 1470 10659 A possible DNA adduct former.
SGTC_1378 2093-0007 380 nM 0.485950894092349 0.31129820094873 no 1044 0.313500991403939 1524 3618014
SGTC_1428 4049-0204 61.7 µM 0.485688666845187 0.311394411923177 no 1045 0.313593960070573 1581 X1428
SGTC_1327 1436-0082 2.18 µM 0.485346881722256 0.311519831958866 no 1046 0.313715152541735 1496 15992205
SGTC_2989 9073649 71.4286 µM 0.484925866156466 0.311674356132376 no 1047 0.313864466712816 1522 21367202
SGTC_210 3551-0445 56.827 µM 0.484565635902563 0.311806596773734 no 1048 0.313992247431848 1536 2865180 YOR207C RET1
SGTC_3099 9120367 49.47 µM 0.484328246943923 0.311893755603082 no 1049 0.31407646613439 1493 24824940
SGTC_405 ebelactone b 50 µM 0.483993683880818 0.312016610393389 no 1050 0.314195175824582 1488 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2438 5259590 200 µM 0.483558445059197 0.312176465594556 no 1051 0.314349636064457 1594 1201127
SGTC_753 1322-0200 289 µM 0.483154226614015 0.31232495926175 no 1052 0.314493116720584 1500 5403907
SGTC_3152 9099253 49.47 µM 0.482902665192963 0.312417388244667 no 1053 0.314582424661112 1549 25236131
SGTC_1464 k208-0027 110 µM 0.481493331575597 0.312935425361185 no 1054 0.315082959001375 1587 X1464
SGTC_1035 k081-0041 55.2 µM 0.480988003347475 0.313121261923957 no 1055 0.315262512524676 1521 731709
SGTC_959 1222-0044 107 µM 0.480853041594256 0.31317090270694 no 1056 0.315310474600929 1559 6083612
SGTC_448 monastrol 171 µM 0.48012416392907 0.313439052409115 no 1057 0.31556955351613 1536 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_487 nimodipine 119 µM 0.480009661429205 0.313481186157392 no 1058 0.315610261571833 1540 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1972 st070201 17.4 µM 0.479643803401773 0.313615828087928 no 1059 0.315740346817427 1599 2829099
SGTC_1769 st044406 64.4 µM 0.478626406904534 0.313990377679662 no 1060 0.316102214417257 1520 670903
SGTC_570 0987-0065 62.6 µM 0.477478135807957 0.314413338408976 no 1061 0.316510843204468 1484 3104428
SGTC_2415 st077333 57.7 µM 0.47618367023841 0.314890441511378 no 1062 0.316971766093068 1753 2766255
SGTC_101 0490-5701 117.494 µM 0.475753132626448 0.315049193937419 no 1063 0.317125131474664 1568 4661669
SGTC_1029 k015-0030 64.7 µM 0.472805814048407 0.316136877095263 no 1064 0.318175862858011 1565 2208316
SGTC_625 k213-0058 121 µM 0.472262743112705 0.316337466958417 no 1065 0.318369629989146 1590 3655420
SGTC_1959 st077091 55.8 µM 0.471956119189961 0.316450746116858 no 1066 0.318479055034282 1502 821356 YKL052C ASK1
SGTC_699 0375-0592 111 µM 0.471387903618736 0.316660713231915 no 1067 0.318681876291872 1556 762578
SGTC_475 α-linolenic acid 10 µM 0.470480157863691 0.316996266174313 no 1068 0.319006003593005 1588 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3250 9135583 49.47 µM 0.469884464098106 0.317216549315576 no 1069 0.319218782253196 1603 7699353
SGTC_2175 5807670 165.306 µM 0.469706905630073 0.317282221656257 no 1070 0.319282216724497 1508 241186
SGTC_988 1497-1057 103 µM 0.468363193094398 0.317779397855233 no 1071 0.31976244236624 1595 3533044
SGTC_1156 4092-0367 4.88 µM 0.466828667232938 0.31834757740063 no 1072 0.320311231974279 1546 1357585
SGTC_990 3985-0011 41.3 µM 0.466452981181664 0.318486745592738 no 1073 0.320445647838352 1528 5399565 YGL099W LSG1
SGTC_2237 6667747 47.222 µM 0.464410614730864 0.31924376237785 no 1074 0.321176793271414 1536 729940 YDL015C TSC13
SGTC_994 3910-0338 138 µM 0.464242151666062 0.319306238054287 no 1075 0.321237132261503 1624 3479481
SGTC_1590 st077108 57.8 µM 0.463419949923503 0.319611230782943 no 1076 0.321531690759018 1569 5489485
SGTC_2967 9089538 49.85 µM 0.462286750458596 0.320031786972363 no 1077 0.321937849921509 1705 728216
SGTC_2338 7999974 200 µM 0.46209853336212 0.320101661053349 no 1078 0.322005330950852 1645 315925
SGTC_234 nsc-17383 10.7 µM 0.461069983897116 0.320483614419604 no 1079 0.322374197978513 1602 408974
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.45915862265015 0.321193906181945 no 1080 0.323060130818955 1620 688761
SGTC_1379 2144-0755 36.5 µM 0.458664143455283 0.32137776907718 no 1081 0.323237683384167 1606 5392327
SGTC_617 3770-0098 35 µM 0.456897344501252 0.322035077832975 no 1082 0.323872416389808 1554 5962639
SGTC_2611 pyromycin 23.93 µM 0.45665254781765 0.322126194437684 no 1083 0.323960401517111 1518 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_122 0236-0016 402.397 µM 0.455815361227559 0.322437887280835 no 1084 0.324261378473784 1579 6808838
SGTC_966 1300-0360 30.2 µM 0.454593547445106 0.322893004673128 no 1085 0.324700838873689 1548 70588
SGTC_2594 a-mangostin 100 µM 0.454254524623092 0.323019335446194 no 1086 0.32482282145854 1663 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1996 st072960 66.8 µM 0.453936602958493 0.323137821804642 no 1087 0.324937228781367 1582 1719405
SGTC_1177 0983-0204 23.6 µM 0.453226217374441 0.32340264054426 no 1088 0.325192927865637 1644 766818
SGTC_2497 7-hydroxyflavone 100 µM 0.452063827254822 0.323836151267705 no 1089 0.325611500852636 1601 5281894
SGTC_214 4373-3496 70 µM 0.451143891951285 0.324179408548093 no 1090 0.325942922611767 1615 3779166
SGTC_2771 fluoxetine 41.05 µM 0.45065365512934 0.32436239266825 no 1091 0.326119594662148 1595 3386 A selective serotonin reuptake inhibitor.
SGTC_2345 9052315 157.45 µM 0.448654105667692 0.325109176656243 no 1092 0.326840598307182 1572 6469265
SGTC_2448 5185112 27.17 µM 0.447465991453484 0.325553242168394 no 1093 0.327269318790027 1532 5718189
SGTC_476 mead acid 10 µM 0.447423462470327 0.325569142251756 no 1094 0.327284669225989 1587 5312531 An omega 9 fatty acid.
SGTC_327 1273-0057 3.96 µM 0.44729063468387 0.325618803909128 no 1095 0.327332614045316 1534 3108138
SGTC_2945 9067681 61.76 µM 0.446518849037592 0.325907420373369 no 1096 0.327611250074149 1573 16456930
SGTC_2375 9072683 200 µM 0.446508668260869 0.325911228267778 no 1097 0.327614926259061 1702 16798029
SGTC_799 1310-0557 151 µM 0.445237457205442 0.326386839229729 no 1098 0.328074080105276 1583 5354492
SGTC_1810 st050138 53 µM 0.444554986381731 0.326642295458573 no 1099 0.328320691773042 1612 3444541
SGTC_187 1488-2104 32.728 µM 0.444047768340064 0.326832205345194 no 1100 0.328504024113677 1635 2852859
SGTC_3050 9093513 49.47 µM 0.443610187240706 0.326996078189871 no 1101 0.328662219586512 1539 25236664
SGTC_3009 9080819 71.4286 µM 0.442583544888317 0.327380683683111 no 1102 0.329033494546232 1550 17027216
SGTC_1420 4'-methoxyflavone 42 µM 0.440295158792484 0.32823862863443 no 1103 0.329861673307955 1650 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1888 azatryptophan 97.5 µM 0.440134491534621 0.328298898944031 no 1104 0.3299198510257 1538 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_698 k064-0052 127 µM 0.438742305251828 0.328821329865267 no 1105 0.330424134724639 1638 5088751
SGTC_524 r073-0010 27.8 µM 0.438192468314771 0.329027753561344 no 1106 0.330623383941689 1515 2772106
SGTC_2964 9083345 53.42 µM 0.43749544105806 0.329289511449389 no 1107 0.330876040806312 1520 17741579
SGTC_2015 5119600 184 µM 0.436789196712944 0.32955481604096 no 1108 0.331132117253574 1686 2828786
SGTC_2226 7298446 200 µM 0.435740976208511 0.329948744035695 no 1109 0.331512336125111 1640 3283010
SGTC_1138 3761-0006 1.03 µM 0.435291243957126 0.33011781416176 no 1110 0.331675519852455 1589 12061087
SGTC_689 0833-0039 98 µM 0.434289999477553 0.330494341651442 no 1111 0.332038932506054 1673 5374726
SGTC_2516 gossypol 71.55 µM 0.433755205261353 0.330695526443221 no 1112 0.332233106702835 1699 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2644 guaiazulene 100 µM 0.43352595223958 0.330781784359628 no 1113 0.332316358164099 1631 3515 A coloring agent.
SGTC_163 TUB2.036 7.546 µM 0.43323520192848 0.330891193949513 no 1114 0.332421953791478 1588 15992207 YJR013W GPI14
SGTC_2895 9054447 58.44 µM 0.433104565362152 0.330940357304738 no 1115 0.3324694031287 1584 2697450
SGTC_1976 st070609 63.5 µM 0.432148453134556 0.331300266288925 no 1116 0.332816760412528 1541 682556
SGTC_100 0086-0128 49.5915 µM 0.430874201161504 0.331780174779128 no 1117 0.333279921537956 1483 93297
SGTC_492 tmb-8 126 µM 0.430684096180923 0.331851795768188 no 1118 0.333349042122199 1616 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3337 9144342 33.5465 µM 0.429965907734966 0.332122424695815 no 1119 0.333610220506805 1647 17682949
SGTC_2016 5121758 140 µM 0.429357485039725 0.332351760051624 no 1120 0.333831544294146 1537 2795203
SGTC_1224 0823-0416 294 µM 0.428985721129509 0.332491921511904 no 1121 0.333966808011188 1650 3598164
SGTC_2151 5563267 85.4165 µM 0.427732964133541 0.332964405054149 no 1122 0.33442277369346 1578 5310824
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.427312414201582 0.333123077077589 no 1123 0.334575895978763 1625 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_155 k072-0202 43.6 µM 0.426632786573732 0.33337956135887 no 1124 0.334823406648813 1568 5857737
SGTC_2661 dactinomycin 12.96 µM 0.424812135202022 0.334067039643592 no 1125 0.335486815294917 1590 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_719 2810-4230 27.3 µM 0.42395351923358 0.334391446669347 no 1126 0.335799855866384 1627 721079
SGTC_48 0382-0018 55 µM 0.422380425614881 0.334986122414635 no 1127 0.33637368154602 1716 762596
SGTC_1563 conessine 56.1 µM 0.422302186310256 0.335015709995366 no 1128 0.336402231277054 1650 441082 An anti-amoebic, histamine inhibitor.
SGTC_130 0136-0219 337.655 µM 0.420952615433136 0.335526235181333 no 1129 0.336894841640595 1680 234244
SGTC_2528 xanthyletin 44.79 µM 0.420337083448534 0.335759183900193 no 1130 0.337119611564505 1607 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2940 9060638 45.86 µM 0.419256187394494 0.336168402843027 no 1131 0.33751445624551 1602 4027022
SGTC_2740 felodipine 17.08 µM 0.417855843814328 0.336698850930692 no 1132 0.338026259217274 1704 3333 L-type calcium channel blocker
SGTC_182 3448-4371 550.524 µM 0.416999216869364 0.337023500275383 no 1133 0.338339490265165 1757 3491403
SGTC_46 0329-0187a 2.197 µM 0.415943057880236 0.337423936550634 no 1134 0.338725835490174 1672 46494817
SGTC_2998 9066762 71.4286 µM 0.415641864160334 0.33753816609662 no 1135 0.338836043923781 1689 4945196
SGTC_677 0929-0063 136 µM 0.415039792466233 0.337766550307037 no 1136 0.339056386606649 1566 1539583
SGTC_217 ketoconazole 989 nM 0.413133611955883 0.338490016583452 no 1137 0.339754362265179 1570 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1402 3909-7673 35.9 µM 0.410135567991939 0.33962909172624 no 1138 0.34085325130089 1582 5328014
SGTC_153 4077-0274 519.67 µM 0.410061166054758 0.339657378644857 no 1139 0.340880539466394 1734 3121976
SGTC_174 3553-0389 74.3 µM 0.408943708473437 0.340082334102176 no 1140 0.341290485968143 1654 738071
SGTC_2642 cholecalciferol 100 µM 0.408020945409873 0.340433402853501 no 1141 0.341629148804874 1659 9821465 A vitamin D precursor, similar to steriods.
SGTC_454 lyso-paf C-16 6.67 µM 0.406878803688059 0.340868126596959 no 1142 0.34204850228972 1518 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3109 9122853 49.47 µM 0.404555564203977 0.341753053439966 no 1143 0.342902113542208 1671 1234709
SGTC_1180 1193-0155 285 µM 0.403871184615522 0.34201390124514 no 1144 0.343153723459769 1584 2921347
SGTC_1619 st003326 88.7 µM 0.403444035549708 0.342176745179042 no 1145 0.343310798676788 1696 2849032
SGTC_2915 7971052 15.16 µM 0.403225263346344 0.342260160046375 no 1146 0.343391258105529 1572 5741558
SGTC_537 1334-0398 209 µM 0.40250856696073 0.342533480526231 no 1147 0.343654892394335 1734 5846986
SGTC_974 1326-0144 138 µM 0.402087887087659 0.342693950097609 no 1148 0.343809673465875 1595 5411856
SGTC_2197 6588183 93.1375 µM 0.401883533543799 0.342771911603236 no 1149 0.343884870873828 1621 884136
SGTC_3253 9135987 49.47 µM 0.399593126987172 0.343646166203415 no 1150 0.344728109760826 1654 4182430
SGTC_3069 9117009 49.47 µM 0.398884166911978 0.343916948097579 no 1151 0.344989278031314 1622 41904981
SGTC_3101 9120531 49.47 µM 0.398754775611862 0.343966376762802 no 1152 0.345036951456955 1712 24824904
SGTC_3305 9127027 53.8275 µM 0.397325737176686 0.344512459765509 no 1153 0.345563635298028 1640 41905295
SGTC_1877 wortmannin 25 µM 0.396071286583588 0.344992094251795 no 1154 0.346026219934585 1723 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2482 5981709 142.65 µM 0.395686689910219 0.345139193290714 no 1155 0.346168087865162 1661 877755
SGTC_1329 1447-1697 50.6 µM 0.39545333110138 0.345228458868839 no 1156 0.346254178520203 1643 2840515
SGTC_871 0574-0004 149 µM 0.394936114437773 0.345426337861061 no 1157 0.346445018235384 1640 9551173
SGTC_127 0180-0333 59.125 µM 0.394238210336045 0.345693412003627 no 1158 0.346702588779045 1645 771601
SGTC_2300 7976697 71.57 µM 0.392442971599113 0.346380767141546 no 1159 0.347365470275737 1573 2236109
SGTC_1443 4112-3303 14 µM 0.389863239272609 0.347369372578046 no 1160 0.348318839039364 1635 704433
SGTC_2317 5986382 200 µM 0.387113697698228 0.348424196517653 no 1161 0.349336018692775 1769 877883
SGTC_2518 prenyletin 46.28 µM 0.386955468635241 0.348484934707906 no 1162 0.34939458779727 1726 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1195 1502-0147 41.1 µM 0.386824608626158 0.348535169882158 no 1163 0.349443028849174 1610 817940
SGTC_1011 4112-3381 17.4 µM 0.386597651984701 0.348622301395488 no 1164 0.349527048247804 1681 2877139
SGTC_1254 0550-0035 264 µM 0.386576658336866 0.348630361524918 no 1165 0.34953482047342 1719 15121435
SGTC_2646 retinol 96.75 µM 0.386006472934978 0.348849299963573 no 1166 0.349745937465118 1662 445354 A vitamin A analog and teratogen.
SGTC_1495 4469-0029 237 µM 0.384541565652812 0.349412022234376 no 1167 0.350288547333084 1623 793680
SGTC_2618 avocadyne 43.43 µM 0.381664173877858 0.350518292395642 no 1168 0.351355238530188 1729 3015189
SGTC_2933 9026794 32.47 µM 0.379165652403806 0.351479928275071 no 1169 0.352282427983123 1712 17586027
SGTC_1468 k284-1086 134 µM 0.379050190685133 0.351524390453597 no 1170 0.352325296560402 1660 15996457
SGTC_95 0471-0001 561.058 µM 0.378459706332113 0.351751806836767 no 1171 0.352544560659733 1571 4015405
SGTC_252 miconazole 1.30953 nM 0.377745437218424 0.352026968005263 no 1172 0.352809855144547 1698 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2839 9003951 25.97 µM 0.3777030491261 0.352043299802131 no 1173 0.352825601219835 1698 2990634
SGTC_1833 st055984 71 µM 0.377026466329146 0.352304018732969 no 1174 0.35307696826456 1679 676288
SGTC_1422 4031-0024 15.5 µM 0.376628578575857 0.352457375882009 no 1175 0.353224823241658 1713 782427
SGTC_1726 st035556 14.5795 µM 0.376482650073781 0.352513626851106 no 1176 0.353279055786721 1752 5919439
SGTC_896 0964-0007 44.5 µM 0.376453818007675 0.352524741111369 no 1177 0.353289771224399 1751 6756758
SGTC_2610 ononetin 44.17 µM 0.375113706790943 0.353041469474947 no 1178 0.353787951779398 1618 259632
SGTC_2128 5255449 168.493 µM 0.374983513256319 0.353091684767076 no 1179 0.353836364025847 1626 736008
SGTC_2397 5161689 200 µM 0.374254596226658 0.353372873319729 no 1180 0.354107454235191 1727 2259942
SGTC_2699 st077704 54.6 µM 0.372882830021933 0.353902265696927 no 1181 0.354617825788653 1661 645852
SGTC_381 3461-2219 42.7 µM 0.372839719093905 0.353918907662938 no 1182 0.354633869632534 1773 2883159
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.372527740435028 0.35403934804762 no 1183 0.354749980985094 1645 16486 A toxic proline analog.
SGTC_140 0062-0056 502.533 µM 0.372455145498196 0.354067375656203 no 1184 0.354777001103316 1565 3758964
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.371056079077351 0.354607684506616 no 1185 0.355297881645478 1714 1241132 A phosphatase inhibitor.
SGTC_886 0866-0150 153 µM 0.370506202855602 0.35482012271612 no 1186 0.355502677843821 1801 271463
SGTC_150 3970-0969 77.2 µM 0.370233267998559 0.354925584659382 no 1187 0.355604345349601 1704 6615640
SGTC_56 0957-0365 83.25 µM 0.369452712817681 0.355227252271086 no 1188 0.355895156754214 1671 6752360
SGTC_2841 9004761 38.96 µM 0.368882502425786 0.355447683568259 no 1189 0.356107653036939 1553 2991039
SGTC_1969 st069479 40.1 µM 0.36877004383583 0.355491163396601 no 1190 0.356149567465347 1750 3895485
SGTC_2120 5538279 151.968 µM 0.36858087043332 0.355564307690697 no 1191 0.356220078184092 1697 2058197
SGTC_3146 9095609 49.47 µM 0.36823403993585 0.355698424247112 no 1192 0.356349365297514 1734 17173999
SGTC_2098 5376439 882.5 nM 0.366352542804031 0.356426294968463 no 1193 0.357051013571227 1798 2844116
SGTC_2684 capsaicin 100 µM 0.364312209079596 0.357216204194732 no 1194 0.35781244194453 1700 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2507 purpurin 79.67 µM 0.364019503419217 0.357329574634289 no 1195 0.357921722732929 1591 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1321 1326-2144 215 µM 0.361722567540197 0.358219657826574 no 1196 0.35877968049414 1770 3513030
SGTC_1560 lithocholic acid 53.1 µM 0.361407016539646 0.358341997007763 no 1197 0.358897601768174 1781 9903 A bile acid which acts as a detergent.
SGTC_2517 totarol 10 µM 0.359787896261472 0.358969958744397 no 1198 0.359502877646634 1620 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3096 9117468 49.47 µM 0.359494126957882 0.359083935534168 no 1199 0.359612735293983 1723 41316311
SGTC_968 1309-0633 340 µM 0.358719983051131 0.359384348410283 no 1200 0.359902288854092 1793 3761976
SGTC_1893 st059353 36.1 µM 0.358618455271198 0.359423753548502 no 1201 0.359940269325487 1646 3112488
SGTC_1780 st038448 24.544 µM 0.35834909914514 0.3595283037595 no 1202 0.360041039310909 1785 728868 YDL195W SEC31
SGTC_1975 st070967 30.8 µM 0.35818635542234 0.359591477609065 no 1203 0.360101928783407 1807 261391
SGTC_26 0302-0163 425.158 µM 0.356033776264595 0.360427426108783 no 1204 0.360907635264825 1726 3100915
SGTC_154 3389-1638 511.116 µM 0.353923236310173 0.361247697071945 no 1205 0.361698206313631 1573 5238686
SGTC_1618 st003135 44.5 µM 0.3531512468125 0.361547893956793 no 1206 0.36198752769033 1794 1270615
SGTC_2455 5377712 9.75 µM 0.35265643216303 0.3617403530962 no 1207 0.362173012714181 1613 2243908
SGTC_562 3772-2733 112 µM 0.350602451543349 0.362539626385524 no 1208 0.362943308543971 1790 2876874 YIL048W NEO1
SGTC_1898 st060199 18.6 µM 0.348710157678954 0.363276512560362 no 1209 0.363653458836434 1671 688866
SGTC_1760 st045453 10.4495 µM 0.347410732512167 0.363782820617326 no 1210 0.36414138575349 1821 3323419 YIL048W NEO1
SGTC_2233 sulbentine 40.3845 µM 0.344970128300444 0.364734420275144 no 1211 0.365058413983247 1706 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3199 9111318 49.47 µM 0.344532880012855 0.364904993087088 no 1212 0.365222786592365 1782 8548020
SGTC_671 0560-0003 407 µM 0.344227098189682 0.365024296044504 no 1213 0.365337752373231 1792 3238678
SGTC_80 0159-0065 512.242 µM 0.343052692751185 0.365482620073173 no 1214 0.365779409794235 1815 1548079
SGTC_2228 7354201 200 µM 0.34302974477209 0.36549157767847 no 1215 0.365788041591176 1804 753451
SGTC_2787 5284540 71.43 µM 0.340438103474453 0.366503680150374 no 1216 0.366763314015769 1694 736958
SGTC_644 1498-1197 63.3 µM 0.339091979128532 0.367029743354356 no 1217 0.36727022030169 1774 6741615
SGTC_1282 0886-0010 32.4 µM 0.337210992586618 0.367765248009909 no 1218 0.367978925610756 1866 2836211 YNL267W PIK1
SGTC_576 1073-0113 22.7 µM 0.335066395559244 0.368604421684977 no 1219 0.368787500768087 1816 5439563
SGTC_2431 5490079 200 µM 0.334772744288434 0.368719375342839 no 1220 0.368898261113187 1680 5722345
SGTC_608 k048-0125 159 µM 0.332747115377363 0.369512653967497 no 1221 0.369662590609573 1817 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_357 1325-0123 420 µM 0.331636334677917 0.369947895096109 no 1222 0.370081939870032 1847 1098503
SGTC_2483 5729050 27.16 µM 0.33128846902857 0.37008423481266 no 1223 0.370213300197752 1857 2865180
SGTC_3306 9127676 59.7925 µM 0.33083917921185 0.370260350076788 no 1224 0.37038298251768 1701 41905287
SGTC_1524 corynanthine 62.1 µM 0.330781438499323 0.370282985594123 no 1225 0.37040479115832 1765 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_931 2812-0076 566 µM 0.330263887312283 0.370485896089081 no 1226 0.370600288596208 1698 3450959
SGTC_1385 3091-4834 14.1 µM 0.328663555662294 0.371113547960029 no 1227 0.37120500183958 1804 4072814
SGTC_156 3474-0145 5.642 µM 0.326712869614586 0.371879072959038 no 1228 0.371942532714726 1877 2265471
SGTC_819 1013-0258 27.7 µM 0.325223768386817 0.372463795433734 no 1229 0.372505860531123 1724 5753198
SGTC_1782 st039423 80.636 µM 0.32456761137748 0.372721540754354 no 1230 0.372754171768788 1685 2068169
SGTC_1239 0337-0584 35.4 µM 0.32434200582002 0.372810174145395 no 1231 0.372839560501525 1878 914301 YML130C ERO1
SGTC_2208 7283366 200 µM 0.323215283728007 0.373252928844081 no 1232 0.373266103426561 1835 898663
SGTC_1704 st028805 70.8 µM 0.322174086995068 0.373662224503324 no 1233 0.373660407168799 1725 2876101
SGTC_2842 9000675 19.48 µM 0.321651843490419 0.373867572743564 no 1234 0.373858231899684 1645 2989072
SGTC_2558 carylophyllene oxide 100 µM 0.317119926455264 0.375651038422951 no 1235 0.375576302750695 1783 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.315894841657948 0.376133609911709 no 1236 0.376041163683363 1867 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1360 1598-0022 39.8 µM 0.314737494977014 0.37658967675523 no 1237 0.376480486546299 1840 761525
SGTC_2154 5570129 200 µM 0.314547271254716 0.376664653281928 no 1238 0.376552709825176 1774 673366
SGTC_2973 9094665 17.96 µM 0.313376620683375 0.377126166578671 no 1239 0.376997272159892 1879 25237061 YIL048W NEO1
SGTC_1896 st058441 89 µM 0.313034125749889 0.377261223843741 no 1240 0.377127367754626 1712 688759
SGTC_638 3970-0837 4.09 µM 0.310990173026451 0.378067534748789 no 1241 0.377904046135625 1733 4118451 YLR208W SEC13
SGTC_2607 solasodine 47.35 µM 0.309363865825176 0.378709470129905 no 1242 0.378522376990725 1729 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2004 4023728 41.89 µM 0.309117642727363 0.37880668844353 no 1243 0.378616019512152 1889 360084 YDR527W RBA50
SGTC_391 gliotoxin 8.33 µM 0.308910055516226 0.378888657787018 no 1244 0.37869497373538 1811 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_735 3076-0345 636 µM 0.30477238953067 0.380523617482389 no 1245 0.380269755829784 1870 2888990
SGTC_877 0771-0151 33.1 µM 0.304488048458629 0.380636050956622 no 1246 0.380378048357347 1790 6166523
SGTC_1453 4237-0541 195 µM 0.304264262676151 0.380724546892164 no 1247 0.380463284734868 1897 739892
SGTC_1717 st033143 58.0435 µM 0.303104678634143 0.381183203469454 no 1248 0.380905044370069 1884 674616
SGTC_1047 2043-3044 82 µM 0.30192010211508 0.381651917853097 no 1249 0.381356485583844 1707 669592
SGTC_465 cgp-37157 41 µM 0.301906360653452 0.381657356107736 no 1250 0.381361723393078 1864 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1226 3909-7979 35.4 µM 0.301849689364372 0.381679784310832 no 1251 0.38138332492021 1880 6615510
SGTC_2224 6650123 117.647 µM 0.301771328339063 0.381710797088236 no 1252 0.381413194583287 1788 2908370
SGTC_910 3454-3003 490 µM 0.300623453927877 0.382165175846373 no 1253 0.381850822329989 1889 820824
SGTC_2650 prasterone 100 µM 0.299727928990886 0.38251977643628 no 1254 0.382192346612398 1819 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_834 0312-0008 75.7 µM 0.299224159651891 0.382719297066897 no 1255 0.382384508274756 1768 6385573 YIL048W NEO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.298464326861491 0.383020291913342 no 1256 0.382674399538617 1779 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1880 MG-132 525 µM 0.297933458907459 0.383230628164479 no 1257 0.382876975205914 1874 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_204 PMA1.184 62.41 µM 0.297927732604836 0.383232897182054 no 1258 0.382879160499542 1798 2252213 YGL008C PMA1
SGTC_1438 4092-1045 4 µM 0.297300094130073 0.383481619921917 no 1259 0.383118704892069 1773 1351342
SGTC_1206 3978-0017 132 µM 0.296955526043905 0.383618186978255 no 1260 0.38325023170127 1857 3873677
SGTC_1346 1488-2224 62.4 µM 0.296316337962751 0.383871562804493 no 1261 0.383494255013087 1913 3722427
SGTC_2490 carminic acid 95.39 µM 0.296294962898573 0.383880036794369 no 1262 0.383502416186546 1798 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_592 k241-0073 46.5 µM 0.294563637085602 0.384566592458609 no 1263 0.384163621814089 1888 4230158
SGTC_2828 7998861 71.43 µM 0.294042752527212 0.38477321973142 no 1264 0.384362617413596 1921 2988188
SGTC_2563 tomatine 8.54 µM 0.293870381252106 0.38484160410193 no 1265 0.384428475812146 2034 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2623 humulene 100 µM 0.292557784586431 0.385362464248341 no 1266 0.38493009276874 1741 6187145 An anti-inflammatory.
SGTC_963 1269-2853 151 µM 0.289145087264914 0.386717645064748 no 1267 0.386235175880189 1724 3668223
SGTC_3198 9112019 49.47 µM 0.289013137497294 0.386770070133056 no 1268 0.386285662048369 1808 45595555
SGTC_2464 5717415 7.67 µM 0.287921147157563 0.387204008915576 no 1269 0.386703549476269 1725 5285744
SGTC_855 0428-0020 25 µM 0.287081219620657 0.387537878100178 no 1270 0.387025065890374 1805 6812414
SGTC_2754 granisetron 64.02 µM 0.286189519528309 0.387892417782584 no 1271 0.387366485202275 1916 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3148 9097893 49.47 µM 0.285617387124325 0.388119946698494 no 1272 0.387585592488664 1675 17174100
SGTC_686 1319-0111 510 µM 0.284116390618481 0.388717054026425 no 1273 0.388160593219662 1904 4562600
SGTC_1296 1068-0102 11.9 µM 0.284091409766999 0.38872699381977 no 1274 0.388170164945661 1883 767053
SGTC_3154 9100113 49.47 µM 0.283251056508425 0.389061409845258 no 1275 0.388492196361285 1760 25237525
SGTC_2127 5253358 187.912 µM 0.28161254145739 0.389713688118285 no 1276 0.389120311290027 1756 20612
SGTC_897 1000-0139 31.4 µM 0.28158131737355 0.389726121171557 no 1277 0.38913228367525 1934 6151020
SGTC_632 0781-2353 4.65 µM 0.281053311731029 0.389936383723666 no 1278 0.38933475508914 1856 6811515 YHR007C ERG11
SGTC_1508 1080-0625 72.9 µM 0.280495141960754 0.390158693265312 no 1279 0.389548826046287 1841 767111
SGTC_1954 st077032 68.9 µM 0.280248519367668 0.390256930304536 no 1280 0.389643422168862 1711 698907
SGTC_1266 0828-0227 32.9 µM 0.280052251236974 0.390335114687006 no 1281 0.38971870868756 1867 3913820
SGTC_3217 9129673 49.47 µM 0.279551993659718 0.390534414825007 no 1282 0.38991062126905 1821 17248312
SGTC_227 fluconazole 33.516 µM 0.279472548187152 0.39056606815543 no 1283 0.38994110121076 1777 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1556 plumbagin 1.48 µM 0.278531671474877 0.390940995236531 no 1284 0.390302128105913 1883 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_59 0330-0160 1.33 µM 0.27678560885452 0.391637046818957 no 1285 0.39097236605024 1864 4293482
SGTC_1232 0279-0259 161 µM 0.275626582621954 0.392099273613883 no 1286 0.391417445136499 1770 1560000
SGTC_422 cantharidin 155 µM 0.274892927878171 0.392391938402267 no 1287 0.391699250327813 1731 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_111 0083-0039 52.457 µM 0.274410165521052 0.392584552044614 no 1288 0.391884715894426 1854 759313
SGTC_3288 9119690 36.221 µM 0.274314713303226 0.392622638908399 no 1289 0.391921389227721 1757 17595618 YKL019W RAM2
SGTC_1921 5740136 50 µM 0.273741642837024 0.392851324210484 no 1290 0.392141586628382 1966 1774243
SGTC_623 k072-0108 16.9 µM 0.273527242352935 0.392936890809401 no 1291 0.392223977054972 1844 5382803
SGTC_812 4251-0442 148 µM 0.273259448625435 0.393043773760062 no 1292 0.392326892374955 1945 5723007
SGTC_875 0709-0210 25.7 µM 0.272775397364691 0.393236990775972 no 1293 0.392512936339233 1976 6251364
SGTC_3118 9124250 49.47 µM 0.272683832550112 0.393273543336064 no 1294 0.39254813182477 1805 1504786
SGTC_2290 7904846 200 µM 0.271285193720595 0.393831994977551 no 1295 0.393085846664326 1777 2962154
SGTC_3071 9117417 49.47 µM 0.2706485707538 0.394086259622049 no 1296 0.393330667709793 1965 45595590 YGL055W OLE1
SGTC_2920 7982904 15.77 µM 0.270349678324691 0.394205651633679 no 1297 0.393445624959198 1808 6456808
SGTC_2722 naftopidil 47.16 µM 0.270018515376344 0.394337945651937 no 1298 0.393573004645824 1908 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_859 0439-0102 54.6 µM 0.269251004169234 0.394644600286724 no 1299 0.3938682666387 1961 610143
SGTC_3180 9109287 49.47 µM 0.268375764247771 0.394994376977418 no 1300 0.394205046391493 1840 18891271
SGTC_1023 4482-3888 16 µM 0.263769238805032 0.396836695540668 no 1301 0.39597886961424 1931 3303168
SGTC_987 1497-1013 404 µM 0.26368839320566 0.396869049363259 no 1302 0.396010019985928 1877 1676435
SGTC_894 0960-0238 55.9 µM 0.262852390936481 0.397203652995795 no 1303 0.396332176378042 1954 6741907 YDL195W SEC31
SGTC_3035 9091303 49.47 µM 0.262826612705371 0.397213971743202 no 1304 0.396342111235667 1846 25237002
SGTC_2718 lomofungin 53.02 µM 0.262622692635396 0.39729560127915 no 1305 0.396420703827762 1946 5351222 A RNA synthesis inhibitor.
SGTC_1249 0481-0015 10.2 µM 0.261771383697581 0.397636430186843 no 1306 0.396748851224295 1791 4227577
SGTC_683 panaxydol 45 µM 0.260767102772423 0.39803860322065 no 1307 0.397136057547537 1938 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2857 9024691 58.44 µM 0.259854325074305 0.398404227003015 no 1308 0.397488072258208 1834 16478292
SGTC_17 0960-0276 49.807 µM 0.25898553164089 0.398752315241846 no 1309 0.397823201910519 1878 6821114
SGTC_2806 7952793 58.44 µM 0.258699054490548 0.398867112013057 no 1310 0.397933724571398 1872 2972490
SGTC_340 k038-0059 454 µM 0.25638158643108 0.399796085797081 no 1311 0.398828102356702 1872 23733424
SGTC_1960 st011366 51.8 µM 0.254654546526697 0.400488751527899 no 1312 0.399494962799975 1863 3972846
SGTC_610 4215-0184 155 µM 0.254505238279596 0.4005486494792 no 1313 0.399552628869262 1868 5605015
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.254501127686048 0.400550298558049 no 1314 0.399554216500258 1992 5024745
SGTC_1672 st016598 6.51 µM 0.251807903311998 0.401631140108337 no 1315 0.400594774083738 1828 4665860 YNL267W PIK1
SGTC_986 1493-0483 84 µM 0.251706165916867 0.401671984046955 no 1316 0.400634095353982 1982 40079
SGTC_449 xestospongin c 11.1929 µM 0.251704950338665 0.401672472064779 no 1317 0.400634565178261 1933 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1643 st009866 20.2 µM 0.251677108003172 0.401683649961019 no 1318 0.400645326355972 1953 3156273 YOR207C RET1
SGTC_1279 0874-0590 65.2 µM 0.251472531955988 0.40176578382139 no 1319 0.400724398155569 1906 3523074
SGTC_3302 9125395 16.351 µM 0.247254433618368 0.403460241769844 no 1320 0.402355660392879 1863 17599668
SGTC_1945 st075991 56.6 µM 0.247086224658302 0.403527851036102 no 1321 0.402420747201512 1816 1084980
SGTC_2801 7907800 81.82 µM 0.245634811655234 0.404111345992412 no 1322 0.402982469432995 1843 6620925
SGTC_1616 st002734 56.1 µM 0.245205881010334 0.404283824979784 no 1323 0.403148511492264 1905 4026101
SGTC_2847 9005661 71.43 µM 0.243494870577891 0.40497203093533 no 1324 0.403811029123156 1956 2991449
SGTC_1977 st070720 65.3 µM 0.241484125101913 0.405781172549564 no 1325 0.404589959405737 1858 682188
SGTC_2457 5731572 11.68 µM 0.240846181704703 0.406037970883217 no 1326 0.404837167556039 1997 2865357
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.240581778349168 0.406144415915823 no 1327 0.404939637103141 1993 77254
SGTC_2717 st081029 62.2815 µM 0.240548745031887 0.406157715147512 no 1328 0.404952439626782 2009 5292846
SGTC_655 k060-0012 42 µM 0.23917244742275 0.406711909378557 no 1329 0.405485933251322 1859 5994525
SGTC_1733 st037357 54.9 µM 0.237820253776692 0.407256579674727 no 1330 0.406010254525971 1758 1272339 YGL099W LSG1
SGTC_43 0570-0105 72.5 µM 0.23748714352547 0.407390785711789 no 1331 0.406139445966855 1879 1114046 YDL195W SEC31
SGTC_1411 3909-8223 150 µM 0.236177481828243 0.407918537607069 no 1332 0.4066474761003 1989 X1411
SGTC_2687 chenodiol 100 µM 0.2359723740325 0.408001204667128 no 1333 0.40672705360536 1895 5702181 A cholesterol synthesis inhibitor.
SGTC_211 3455-0679 143.504 µM 0.234908762657907 0.408429950348203 no 1334 0.407139774120627 1876 748649
SGTC_919 tnp00227 403.569 nM 0.233500010873583 0.408997992098573 no 1335 0.407686580555601 1873 1269246 A methoxyflavone. YNL221C POP1
SGTC_1856 st057054 55.7 µM 0.233150479888688 0.409138960834519 no 1336 0.407822278760673 2011 1266018
SGTC_1570 verbenone 133 µM 0.232603150257807 0.409359727002306 no 1337 0.408034790426801 2021 29025 A natural terpanoid with antifungal properties.
SGTC_1318 1280-3875 124 µM 0.23253035403876 0.409389091626068 no 1338 0.408063057053415 1923 373245
SGTC_645 0845-0943 5.41 µM 0.232328472095445 0.40947052965935 no 1339 0.408141449912231 1897 1885106
SGTC_593 1203-0218 61.7 µM 0.228879559969528 0.410862401940241 no 1340 0.409481263843311 2012 3666956
SGTC_2046 4110841 106 µM 0.228171232406611 0.411148400219879 no 1341 0.409756562398725 2029 44119630 YMR134W ERG29
SGTC_1892 st058411 7.36 µM 0.226221704919971 0.411935795739055 no 1342 0.410514495031385 2004 3934738
SGTC_741 4582-0002 126 µM 0.225881348227383 0.412073299011307 no 1343 0.410646852449909 1860 2912688
SGTC_2346 9031566 143.75 µM 0.223117234594912 0.413190392574498 no 1344 0.411722132581581 1991 4771086
SGTC_2225 6654152 15.4 µM 0.222250775182264 0.413540710138504 no 1345 0.412059334738121 1991 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2306 7482397 179.52 µM 0.220431745552924 0.414276384285669 no 1346 0.412767462000103 2006 891448
SGTC_2141 5621638 7.665 µM 0.21861718743531 0.415010549785344 no 1347 0.413474131505603 2013 2856238
SGTC_1273 0849-0096 14.1 µM 0.216571592927213 0.415838547917553 no 1348 0.414271112937172 1901 5286025
SGTC_1109 tnp00067 928.257 nM 0.216368262203736 0.41592087085896 no 1349 0.414350351705919 1898 676295
SGTC_1494 4358-1428 177 µM 0.215267478802082 0.416366611336118 no 1350 0.414779391695621 2072 1564571
SGTC_2282 7944268 200 µM 0.213999339677257 0.416880252527433 no 1351 0.415273786057229 1988 2970414
SGTC_2017 5132927 60.65 µM 0.213352255530315 0.417142399230665 no 1352 0.415526108831965 1894 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1716 st033144 30.6155 µM 0.213303024757988 0.41716234510862 no 1353 0.415545307214019 2041 674617
SGTC_2426 5582046 32.21 µM 0.211604548369022 0.417850614087832 no 1354 0.416207780300399 1972 2251934
SGTC_2664 lyso-paf C-16 73.48 µM 0.21155346919243 0.417871316673003 no 1355 0.416227706900731 1952 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1387 3342-1166 1.8 µM 0.211278057956445 0.417982945818347 no 1356 0.416335151841287 1937 3418228
SGTC_1477 0139-0234 16 µM 0.20971255274891 0.41861759861333 no 1357 0.416946013856679 1980 620880
SGTC_1651 st011928 86.1 µM 0.209584633812645 0.41866946609018 no 1358 0.416995936863382 1974 720198
SGTC_3287 9117173 37.0625 µM 0.209492172935467 0.418706957216731 no 1359 0.417032022463636 2061 2789709
SGTC_221 trifluoperazine 10.304 µM 0.209308786730352 0.418781319018103 no 1360 0.417103596438225 1991 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2723 salbutamol 83.58 µM 0.209229299042551 0.418813551611664 no 1361 0.417134620616338 2017 9884233 β2-adrenoceptor agonist
SGTC_2156 5649887 115 µM 0.208892913311505 0.418949963479349 no 1362 0.417265918242257 2038 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3057 9095946 49.47 µM 0.207464984538915 0.419529128526581 no 1363 0.417823368017847 1994 24540043
SGTC_883 0850-0245 24.6 µM 0.206453516281651 0.41993948360233 no 1364 0.41821833557771 2024 6823229 YPR165W RHO1
SGTC_1692 fluoroquinolonic acid 71 µM 0.204984096742765 0.42053578559475 no 1365 0.418792275081829 2001 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_403 arphamenine a 50 µM 0.204795985087983 0.420612135980623 no 1366 0.418865761984538 1957 5487158 An arginine aminopeptidase inhibitor.
SGTC_2271 7849410 118.62 µM 0.204589500204252 0.420695947094635 no 1367 0.418946429754378 2089 972430
SGTC_1574 spiramycin 23.7 µM 0.204581871901108 0.420699043451112 no 1368 0.418949409980696 1971 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3051 9093778 49.47 µM 0.204496014053035 0.420733893807711 no 1369 0.418982953255023 2069 17217378
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.20349024080567 0.421142191048384 no 1370 0.419375936412006 1976 3256 An antibiotic and ribosome inhibitor.
SGTC_2636 apigenin dimethyl ether 100 µM 0.203146063282003 0.421281930644635 no 1371 0.419510434489877 1965 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_116 0155-0182 31.788 µM 0.20023636560413 0.422463692242472 no 1372 0.420647863703826 1918 771486
SGTC_1311 1190-0148 100 µM 0.20021845867396 0.422470967240362 no 1373 0.420654865759381 2023 1961333
SGTC_13 0199-0087 65 µM 0.199794580448622 0.42264318276567 no 1374 0.420820620025211 2046 4589825
SGTC_2276 7947513 42.08 µM 0.199483538922816 0.422769563798004 no 1375 0.420942259313595 1787 2105100
SGTC_77 0828-0286 12.516 µM 0.198513648716014 0.423163696328668 no 1376 0.421321603556404 2069 745345
SGTC_762 1165-0429 115 µM 0.198423299012697 0.423200415496227 no 1377 0.421356944929932 2063 5967793
SGTC_792 4534-1957 155 µM 0.197578880291619 0.423543629271472 no 1378 0.421687280068023 1958 1717904
SGTC_2961 9083290 32.55 µM 0.197195486904859 0.423699478582442 no 1379 0.42183728110276 2046 17741490
SGTC_596 1155-0152 116 µM 0.197079483758989 0.423746636183977 no 1380 0.421882669076869 1918 280313
SGTC_754 3474-0146 171 µM 0.194795527937904 0.424675331542568 no 1381 0.422776511708567 1845 24762078
SGTC_1182 1222-0449 220 µM 0.193723788700046 0.42511126348767 no 1382 0.423196082002177 1998 658318
SGTC_924 2046-0044 21.3 µM 0.192486772140228 0.425614536124708 no 1383 0.423680464238807 2086 3623589
SGTC_2706 st078239 82.5 µM 0.19210846679708 0.425768471585013 no 1384 0.423828621447287 2046 15434492
SGTC_1298 1079-1278 263 µM 0.191507235080848 0.426013140833455 no 1385 0.424064106334407 1955 2840950
SGTC_3049 9092223 49.47 µM 0.191376208720926 0.426066465358535 no 1386 0.424115429130584 1975 8623917
SGTC_1640 st009078 66.4 µM 0.18941954585165 0.426862939615191 no 1387 0.424882003195166 2057 690618
SGTC_3181 9108277 49.47 µM 0.188576308890369 0.427206277692526 no 1388 0.425212451205664 1954 17097298
SGTC_885 0865-0106 16.8 µM 0.188079870617815 0.427408436672017 no 1389 0.425407020208943 1945 2793380
SGTC_842 0271-0008 11.1 µM 0.187697181326343 0.427564287946036 no 1390 0.425557019988178 2027 1221709
SGTC_1878 temozolomide 1 mM 0.186687236975244 0.427975644798581 no 1391 0.425952931794285 2110 5394 DNA alkylating agent.
SGTC_1690 st023502 41.2 µM 0.186548053660358 0.428032341209164 no 1392 0.426007499392627 2077 24207482
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.186467972148922 0.428064963136504 no 1393 0.426038896440006 1996 6708739 YPR165W RHO1
SGTC_3219 9131112 49.47 µM 0.186457011791513 0.428069427975393 no 1394 0.426043193633904 2083 17612988 YMR079W SEC14
SGTC_2991 9074669 71.4286 µM 0.185870206608845 0.428308483848079 no 1395 0.426273273360576 2040 17333109
SGTC_2511 berberine 10.47 µM 0.184817292851886 0.428737491459366 no 1396 0.426686171891923 1944 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1013 4112-3890 241 µM 0.184254008712732 0.428967035068195 no 1397 0.426907095933532 1952 705171
SGTC_563 tetrahydrosecaminediol 614 µM 0.183681238106634 0.429200469138223 no 1398 0.42713176414732 2084 334274 A psychoactive constituent of the cannabis plant.
SGTC_303 1348-1668 34.2 µM 0.18353468616489 0.429260200724412 no 1399 0.427189252676813 2004 5380509
SGTC_2520 obtusaquinone 4.71 µM 0.181984537125838 0.429892108814534 no 1400 0.427797430427115 2080 5967872
SGTC_832 4083-0019 164 µM 0.180429650656367 0.430526128551945 no 1401 0.428407639216259 2060 1990758
SGTC_1351 1496-0003 46.5 µM 0.180275347475741 0.430589056937622 no 1402 0.428468204225818 2081 3891978
SGTC_783 0848-0141 92.7 µM 0.179223458850849 0.431018088193442 no 1403 0.428881122221689 1992 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1860 st056228 74.6 µM 0.178994051682251 0.431111666769065 no 1404 0.428971186169126 1962 688679
SGTC_1991 st073000 8.92 µM 0.177531707024773 0.431708269455392 no 1405 0.429545381082951 2070 4301969 YIL048W NEO1
SGTC_2553 4-methylesculetin 85.09 µM 0.176762683898054 0.43202207564434 no 1406 0.429847400684575 1923 5319502
SGTC_2153 5569715 200 µM 0.176715102170283 0.432041493169432 no 1407 0.429866088878166 2042 2054701
SGTC_3145 9085516 49.47 µM 0.176444515210388 0.432151919540776 no 1408 0.42997236756599 1874 25236195
SGTC_872 0588-0139 234 µM 0.175289410054722 0.432623376751066 no 1409 0.430426116248187 2089 2047100
SGTC_1742 st038235 28.8875 µM 0.17159339501391 0.434132549988231 no 1410 0.431878600224562 1988 564103 YBR002C RER2
SGTC_1653 st012112 65 µM 0.171573305467249 0.4341407556855 no 1411 0.431886497680361 2084 720429
SGTC_588 3970-1144 52.9 µM 0.170765401577757 0.434470772413454 no 1412 0.432204117480171 2089 1888707
SGTC_1697 st025554 27.742 µM 0.169943507464414 0.434806550801123 no 1413 0.432527282370795 2021 1269519
SGTC_320 4092-0846 5.34 µM 0.168246731245651 0.435499903896296 no 1414 0.433194589336422 2091 1359356
SGTC_2888 9058547 12.99 µM 0.16746593699821 0.435819026346332 no 1415 0.433501723674505 1987 16476514
SGTC_1940 st075990 51.1 µM 0.167233398870971 0.435914076291834 no 1416 0.433593202973724 2053 1084979
SGTC_2427 5545055 42.75 µM 0.166700163822866 0.436132050053293 no 1417 0.433802988314262 2029 5372858
SGTC_1906 st060206 94.7 µM 0.165178351536244 0.436754237061185 no 1418 0.434401802086367 2099 5133468
SGTC_2301 7769476 200 µM 0.164734963238363 0.436935544141704 no 1419 0.43457629812052 2035 977820
SGTC_1185 1319-0113 81.3 µM 0.164503664630739 0.437030130326609 no 1420 0.434667331045569 2039 4672763
SGTC_2795 7780010 54.55 µM 0.164343498457275 0.437095630051885 no 1421 0.434730370183412 2013 953673
SGTC_2569 tetrandrine 100 µM 0.164265360035127 0.437127585272654 no 1422 0.43476112496222 1920 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_523 1934-0222 13.7 µM 0.163763188655656 0.437332961335354 no 1423 0.43495878578989 1934 1361595
SGTC_1786 berberine 21.6 µM 0.163248958256699 0.437543286747899 no 1424 0.435161210041423 2096 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1098 clofazimine 15.1 µM 0.161043798177277 0.438445418827362 no 1425 0.436029452433435 2094 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2942 9052777 62.25 µM 0.160420940238247 0.438700288466597 no 1426 0.436274747654566 2025 6469503
SGTC_573 3702-0553 84.7 µM 0.160398037373823 0.438709660663118 no 1427 0.436283767776493 2044 1222756
SGTC_2792 7535235 81.82 µM 0.159951977301383 0.438892201998718 no 1428 0.436459451802849 1965 1281891
SGTC_2217 6934799 96.0675 µM 0.158604753269964 0.439443605765366 no 1429 0.436990141818251 2120 675606
SGTC_829 1635-0120 117 µM 0.15850355099296 0.439485031486822 no 1430 0.437030011373785 2125 285054
SGTC_393 acivicin 6.25 µM 0.158355368048476 0.439545689275776 no 1431 0.437088390543361 2025 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1768 st044301 37.178 µM 0.158042881066462 0.439673608576045 no 1432 0.437211504547877 1993 3931349
SGTC_2983 9022671 12.99 µM 0.157910443729471 0.439727824868406 no 1433 0.437263684207593 2167 6405161
SGTC_2009 4012297 12.05 µM 0.157614354279679 0.439849040031911 no 1434 0.437380345941004 1976 45595307
SGTC_2189 6047310 154.431 µM 0.156320116096123 0.440378950329141 no 1435 0.437890350450611 2051 711535
SGTC_3239 9133757 49.47 µM 0.155545962404022 0.440695969379554 no 1436 0.438195461042899 2075 17036923
SGTC_1090 efavirenz 20.7 µM 0.153465610168292 0.441548069756355 no 1437 0.439015554064035 2065 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1284 0929-0043 16 µM 0.152766624540944 0.441834431202758 no 1438 0.439291159249599 2030 1239883
SGTC_2 0422-0095 29 µM 0.152600709752865 0.441902407884276 no 1439 0.43935658262694 2065 6790840
SGTC_1062 mesoridazine 14.2 µM 0.152475947999978 0.441953524948955 no 1440 0.439405779665853 2121 4078 A neuroleptic.
SGTC_2812 7970281 58.44 µM 0.152383318519395 0.441991477486937 no 1441 0.439442306659006 2111 2233435
SGTC_192 3455-0609 60.9 µM 0.151851280570791 0.442209476601687 no 1442 0.439652117514688 2067 3769639
SGTC_918 glabranin 770.725 nM 0.151596923621923 0.442313703907381 no 1443 0.439752429978601 2055 124049 Also referred to as licorice root.
SGTC_1375 2910-0797 186 µM 0.151107518777846 0.442514257516175 no 1444 0.439945450740662 2052 742508
SGTC_2499 avocadenofuran 51.48 µM 0.1506912210623 0.442684864093322 no 1445 0.440109649364584 2001 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1713 st033146 12.748 µM 0.150463018001015 0.442778390481091 no 1446 0.440199662947701 2131 674619
SGTC_499 genistein 192 µM 0.150383587053769 0.442810945085371 no 1447 0.440230994822317 2159 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1788 fluconazole 20 µM 0.148418168120782 0.443616590271304 no 1448 0.441006381386391 1989 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2963 9082507 9 µM 0.148326602992842 0.443654129455958 no 1449 0.441042510708553 2082 16459611
SGTC_2900 5328528 85.29 µM 0.14778773770525 0.443875059639226 no 1450 0.441255143480313 2096 795359
SGTC_943 3253-1379 105 µM 0.147146824532209 0.444137851293775 no 1451 0.441508065733747 2099 668464
SGTC_440 fluspirilene 35.1 µM 0.146275194936048 0.44449528228793 no 1452 0.441852073397079 2088 3396 An atypical antipsychotic.
SGTC_3056 9094900 49.47 µM 0.146083070577969 0.4445740732121 no 1453 0.441927905381109 2017 25236784
SGTC_1210 3013-0140 750 nM 0.145436035790993 0.444839440710371 no 1454 0.442183307332905 2175 905973
SGTC_942 3253-1115 227 µM 0.143801504633059 0.445509918604806 no 1455 0.442828607350435 2136 46497897
SGTC_1811 st050069 61.5 µM 0.143426357897748 0.445663824301068 no 1456 0.442976733789052 2181 3877702
SGTC_1796 st049173 110.4 µM 0.1424487132929 0.44606494597364 no 1457 0.443362793509046 2147 94134
SGTC_3125 9127534 49.47 µM 0.141295890541152 0.446538013080215 no 1458 0.44381809795996 2181 1639235
SGTC_45 0kpi-0036 14.9 µM 0.140727952114273 0.446771097733293 no 1459 0.444042431123054 2064 2795021
SGTC_1817 st052116 64.4 µM 0.139960141832175 0.447086239975149 no 1460 0.444345741276608 2128 4361398
SGTC_1396 3511-0007 98.6 µM 0.139449952554285 0.447295662007466 no 1461 0.444547300750986 2045 X1396
SGTC_693 4161-2696 114 µM 0.138565357145761 0.447658804724519 no 1462 0.444896810077189 2123 805759
SGTC_2597 laccaic acid a 100 µM 0.138095315144598 0.447851783499144 no 1463 0.445082544138314 2060 5491415 A textile dye.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.138034275147642 0.447876844770021 no 1464 0.44510666458425 2199 136420
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.137802365265547 0.447972062207751 no 1465 0.445198307492258 2127 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1253 0550-0034 176 µM 0.137168761680015 0.448232222103547 no 1466 0.445448701024645 2058 5969915
SGTC_1539 benzyladenosine 56 µM 0.136987179526583 0.448306784494401 no 1467 0.445520464415383 2105 92208 A nucleotide analog.
SGTC_1914 st062367 72.6 µM 0.136771075351862 0.448395524911694 no 1468 0.445605873638921 2064 978205
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.135139766486366 0.449065484055714 no 1469 0.446250684719955 2122 5377381
SGTC_666 0272-0154 136 µM 0.133666101942233 0.449670825481339 no 1470 0.446833305649598 2077 6870312
SGTC_2468 5987765 72.9 µM 0.133250956889146 0.449841377018097 no 1471 0.446997456176673 2098 26772094
SGTC_2849 9019321 12.99 µM 0.132754979386484 0.450045148606644 no 1472 0.447193580180177 2091 16489627
SGTC_504 lovastatin 124 µM 0.132535374704328 0.450135377060324 no 1473 0.447280422418856 1998 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_561 1550-0330 72.9 µM 0.131624460475997 0.450509669692766 no 1474 0.447640668595665 2043 6812934
SGTC_3149 9097855 49.47 µM 0.131558416508956 0.450536808727533 no 1475 0.447666789188501 2165 25236625 YMR079W SEC14
SGTC_999 SEC7.066 22.7 µM 0.131474913531087 0.450571122415593 no 1476 0.447699815198878 2079 740511 YDR170C SEC7
SGTC_927 2425-1185 123 µM 0.131436075763623 0.450587082056607 no 1477 0.447715175930445 2042 730375
SGTC_895 0964-0006 13.7 µM 0.131366635606089 0.450615617366225 no 1478 0.447742640413577 2166 6738897
SGTC_706 4262-0057 46.9 µM 0.131320560036514 0.450634551517209 no 1479 0.447760864037347 2138 883298
SGTC_2370 9071495 200 µM 0.129963569964013 0.451192238985042 no 1480 0.448297624570678 2003 21791103
SGTC_3018 9082602 49.47 µM 0.129043591283749 0.451570381060757 no 1481 0.448661578153422 2078 17332089
SGTC_1820 st053765 18.6 µM 0.127830702490269 0.452068986120529 no 1482 0.449141476153744 2046 3690829
SGTC_2332 7982454 138.89 µM 0.127696703648263 0.452124076202655 no 1483 0.449194499422074 2176 2981748
SGTC_2076 5212012 200 µM 0.12763701715595 0.452148615023183 no 1484 0.449218117626495 2174 604802
SGTC_330 1488-0319 80.1 µM 0.127542287681265 0.452187561389191 no 1485 0.449255602860711 2075 6846614
SGTC_2223 6903751 107.57 µM 0.127345279727132 0.452268559235376 no 1486 0.449333561982558 2145 5598863
SGTC_261 5-fluorouridine 15.376 µM 0.127120320062468 0.452361051576417 no 1487 0.449422584424092 2168 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.126435756561698 0.452642526275015 no 1488 0.449693499804331 2056 75037 A free radical scavenger.
SGTC_672 1441-0018 53.7 µM 0.124935863255286 0.453259326380604 no 1489 0.450287163012314 2084 251141
SGTC_801 0866-0028 10.1 µM 0.124462450438198 0.453454031097978 no 1490 0.450474564683778 2061 6849771
SGTC_1418 3966-3099 2.4 µM 0.124155109998328 0.453580439738399 no 1491 0.450596232094977 2156 740335
SGTC_1738 st035555 74 µM 0.123640287942292 0.453792195772807 no 1492 0.450800046021907 2114 5331140
SGTC_1039 k821-0043 94 µM 0.122026542866416 0.45445604445208 no 1493 0.451438998592218 2182 15992768
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.121973867197551 0.4544777158737 no 1494 0.451459857333348 2188 88881 An O-methylated flavonoid and antioxidant.
SGTC_1173 0443-0020 122 µM 0.121851001654513 0.454528264804149 no 1495 0.45150851068779 2086 5331295
SGTC_212 3807-4682 38.772 µM 0.12131758507308 0.454747729796874 no 1496 0.451719746009857 2158 3125501 YBL034C STU1
SGTC_767 0929-0023 86 µM 0.119543712568095 0.455477657828402 no 1497 0.452422305343694 2200 1204563
SGTC_2652 actinonin 100 µM 0.118599517103062 0.455866244805757 no 1498 0.45279632397428 2196 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_345 1362-0200 395 µM 0.117908001200047 0.456150867422772 no 1499 0.453070276717103 2053 1419823
SGTC_2388 9080168 200 µM 0.117393642534074 0.456362588087669 no 1500 0.453274060881037 2065 15943073
SGTC_1657 st012939 43.4 µM 0.117388757002347 0.456364599133065 no 1501 0.453275996542769 2178 24207257
SGTC_235 0330-0087 5 mM 0.1173127342205 0.456395892752154 no 1502 0.453306117130759 2141 46494818 YHR062C RPP1
SGTC_2056 5235370 200 µM 0.116598543249861 0.456689891755138 no 1503 0.453589096084813 2085 5511916
SGTC_2210 7115885 190.385 µM 0.116276453070528 0.456822488977165 no 1504 0.453716723370205 2171 2927039
SGTC_191 3914-0123 66.505 µM 0.114662891827148 0.457486827620966 no 1505 0.454356163953015 2085 3144412
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.113154938978294 0.458107792404849 no 1506 0.454953859815561 2187 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1794 st048918 76.9 µM 0.112953125800415 0.45819090549842 no 1507 0.455033858746032 2209 672303
SGTC_1287 0971-0001 34.6 µM 0.112182123503054 0.458508445598947 no 1508 0.455339501534024 2131 4665869
SGTC_1196 1588-0294 184 µM 0.111561486856419 0.458764076305838 no 1509 0.455585555183917 2084 6144269
SGTC_1518 st038567 90.8 µM 0.110352892188115 0.459261926739975 no 1510 0.456064755731826 2213 77966
SGTC_305 1682-2595 20.8 µM 0.11021798381502 0.459317502858367 no 1511 0.456118250072008 2137 226033
SGTC_1655 st012546 55.1 µM 0.109261626420244 0.459711501372361 no 1512 0.45649749100258 2155 720985 YLR208W SEC13
SGTC_1231 0242-0792 125 µM 0.107167159411843 0.460574514063472 no 1513 0.457328184173103 2122 3707635
SGTC_1190 1486-1332 13 µM 0.106831057431905 0.460713020288465 no 1514 0.457461504097075 2199 4150046
SGTC_3019 9081971 49.47 µM 0.106707268668916 0.460764034323655 no 1515 0.457510607985603 2200 16451803
SGTC_2822 7994718 71.43 µM 0.106658393190739 0.460784176356908 no 1516 0.457529995837042 2224 1018011
SGTC_1899 st063254 59.6 µM 0.105790944061309 0.46114167679829 no 1517 0.457874111030272 2153 3093813
SGTC_2321 7390090 138.78 µM 0.105749822186877 0.461158625073491 no 1518 0.45789042477495 2084 649046
SGTC_102 gallobenzophenone 83.616 µM 0.103634077209788 0.462030718441395 no 1519 0.458729871777419 2224 70837
SGTC_2932 9016711 44.54 µM 0.103509669556782 0.462082004017668 no 1520 0.458779237761094 2226 7117328
SGTC_607 4491-0986 66.8 µM 0.10329651628347 0.462169875386064 no 1521 0.458863820216741 2210 698981 YDR232W HEM1
SGTC_360 0957-0399 1.01 µM 0.102400336915795 0.462539340989171 no 1522 0.459219458129526 2208 6752301 YPR165W RHO1
SGTC_2698 st077697 67.5 µM 0.101976386804658 0.462714133111415 no 1523 0.459387708978536 2107 3154499
SGTC_99 0109-0120 622.8 µM 0.101359651440122 0.462968422299067 no 1524 0.459632482476102 2209 759414
SGTC_2419 paclitaxel 166.5 µM 0.101136099439229 0.463060599865021 no 1525 0.459721210870186 2067 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_249 wiskostatin 11.211 µM 0.101135681600694 0.463060772154934 no 1526 0.459721376713311 2222 2775510 A n-wasp and actin depolymerizer.
SGTC_2781 5567276 71.43 µM 0.100315271763411 0.463399070070911 no 1527 0.46004701676817 2191 2853274
SGTC_292 k038-0015 474 µM 0.0999541628885338 0.463547982564253 no 1528 0.460190357922831 2190 46368540
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0999019793211004 0.463569502217673 no 1529 0.460211072471801 2203 5106787 A p450 inhibitor.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0981002488266799 0.464312571480147 no 1530 0.460926344972829 2259 16623 A steroid.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0977349955164625 0.464463224424241 no 1531 0.461071363084747 2196 17037758
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0968236971947628 0.464839122103127 no 1532 0.461433202354403 2175 641818 YHR062C RPP1
SGTC_950 1165-0508 94.1 µM 0.0963517062102744 0.465033824070697 no 1533 0.461620623228267 2131 6148369
SGTC_3029 9088683 49.47 µM 0.0962522600557155 0.465074847876886 no 1534 0.461660112963392 2162 25236615
SGTC_995 3931-2021 34.6 µM 0.0961714390179701 0.465108188671179 no 1535 0.46169220700542 2145 730143
SGTC_455 paf C-16 10 µM 0.0952305194201864 0.465496360607307 no 1536 0.462065864573298 2210 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1730 st033808 45.1 µM 0.0949361551613626 0.465617805951745 no 1537 0.462182769266957 2048 1045166
SGTC_1386 3228-0095 33.8 µM 0.09467955817123 0.465723672333218 no 1538 0.462284677621195 2213 870181
SGTC_3022 9087993 49.47 µM 0.0943750138115095 0.465849323912192 no 1539 0.462405631646367 2247 17173644
SGTC_1363 1636-0063 10.4 µM 0.0936825807988983 0.46613502663906 no 1540 0.462680653961503 2196 6072185
SGTC_1748 st037455 53.6035 µM 0.0936112657013993 0.466164452743263 no 1541 0.462708980089928 2170 580690
SGTC_1473 k844-0725 134 µM 0.0927646152574452 0.466513812553791 no 1542 0.463045281345269 2245 54682906
SGTC_1285 0929-0069 65.5 µM 0.0919193951290486 0.466862607900005 no 1543 0.463381040806611 2149 1206237
SGTC_1409 3909-8004 61.9 µM 0.0916032249009732 0.466993087807667 no 1544 0.463506644562686 2148 2119279
SGTC_366 0181-0206 4.31 µM 0.0914170038311731 0.467069940815676 no 1545 0.463580625609044 2243 274874
SGTC_641 4092-0595 30 µM 0.0911856104529292 0.467165438041835 no 1546 0.463672554255905 2210 786260
SGTC_2245 6637752 200 µM 0.0911552729379721 0.467177958629088 no 1547 0.463684606977659 2241 681890
SGTC_2361 9034121 116 µM 0.0900808524120655 0.467621403272169 no 1548 0.464111482456476 2148 6496917
SGTC_2832 7992762 51.95 µM 0.0889581456375167 0.46808481998249 no 1549 0.464557586566778 2062 2985177
SGTC_1437 4092-1038 11.6 µM 0.0889337177389548 0.468094903504724 no 1550 0.464567293415015 2220 3977136
SGTC_1587 estradiol valerate 56.1 µM 0.0888481423039846 0.468130228104675 no 1551 0.464601298461345 2260 13791 A steroid.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0885031616761222 0.468272634862048 no 1552 0.464738385773877 2192 390807
SGTC_2108 5365811 200 µM 0.0871055060649454 0.468849623406337 no 1553 0.465293824408369 2201 780283
SGTC_1127 asiatic acid 681.4 nM 0.0862774037230882 0.469191516512004 no 1554 0.465622950351138 2156 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1117 retinoic acid 1.10837 µM 0.0862539962619927 0.469201180926119 no 1555 0.46563225389514 2236 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2206 7254556 146.969 µM 0.0848092893777238 0.469797702799862 no 1556 0.466206504147608 2251 4398905
SGTC_2745 rifampicin 24.3 µM 0.0845989440451346 0.469884560422772 no 1557 0.466290119294975 2259 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1642 st009582 77.7 µM 0.0821715138155361 0.470887018653151 no 1558 0.467255162751378 2243 6739311
SGTC_2638 epoxomicin 18 µM 0.0818453520298131 0.471021728204807 no 1559 0.467384845659733 2257 9915668 A protesome inhibitor.
SGTC_2435 5706476 10.6 µM 0.081782774553701 0.471047573990325 no 1560 0.46740972704895 2254 5725375
SGTC_483 fpl-64176 144 µM 0.0817416245002558 0.47106456987576 no 1561 0.467426088764105 2247 3423
SGTC_285 1486-1325 46 µM 0.081458515143692 0.471181501750813 no 1562 0.467538657657476 2255 22310230
SGTC_1269 0831-0796 3.05 µM 0.0810130611105765 0.471365491425067 no 1563 0.467715782692031 2261 927758
SGTC_2557 derrustone 83.84 µM 0.0807282049988922 0.471483151177892 no 1564 0.467829052835439 2084 629853 An antioxidant.
SGTC_3279 9140807 49.47 µM 0.0806073440339493 0.471533073524923 no 1565 0.467877112759785 2237 45595718
SGTC_1057 3448-5381 134 µM 0.0798152963420697 0.471860244612962 no 1566 0.468192079208111 2248 5497911
SGTC_1037 k284-1091 78.7 µM 0.0785414324409072 0.472386479228209 no 1567 0.468698686836448 2264 3334711
SGTC_1634 st006576 41 µM 0.0776546760982726 0.472752827786371 no 1568 0.469051374206576 2266 3915356
SGTC_903 1134-0042 114 µM 0.0773161903794699 0.472892673597544 no 1569 0.469186005699993 2184 701009
SGTC_376 3970-0862 59.1 µM 0.0762265845770446 0.47334286824318 no 1570 0.46961941639046 2276 3135186
SGTC_2344 7990960 76.95 µM 0.0760989157864917 0.47339561965666 no 1571 0.469670201359229 2185 140813
SGTC_1147 3809-1045 12.3 µM 0.0760794450740455 0.473403664793112 no 1572 0.469677946596399 2162 325925
SGTC_1024 4507-0395 26 µM 0.0747684150639536 0.473945396280436 no 1573 0.47019948628981 2168 4201836
SGTC_2481 5478948 45.16 µM 0.0718958390772895 0.475132542170644 no 1574 0.471342400708739 2186 77792
SGTC_2067 5224629 34.075 µM 0.071815539013028 0.475165730899456 no 1575 0.471374353203712 2184 2835000
SGTC_2878 9043973 25.97 µM 0.0708051037721795 0.475583367397817 no 1576 0.47177643489979 2264 6465167
SGTC_138 0850-0259 40.9225 µM 0.0705554374270846 0.475686564483791 no 1577 0.47187578887901 2297 6813004
SGTC_132 0417-1715 25.805 µM 0.0703349810797855 0.475777689265531 no 1578 0.471963520281713 2296 6769098
SGTC_2821 7996764 71.43 µM 0.0702820492427879 0.475799568625198 no 1579 0.471984584900841 2223 2987135
SGTC_1323 1348-1351 11.2 µM 0.0695859028402462 0.476087327307084 no 1580 0.47226162882176 2157 6989654
SGTC_1120 ficusin 1.78878 µM 0.0688682911658959 0.476383971914381 no 1581 0.472547229278353 2203 6199 A DNA cross-linker.
SGTC_594 1487-1584 10.8 µM 0.0685627501186358 0.47651027972817 no 1582 0.472668835080332 2250 5013332
SGTC_2923 7992654 58.14 µM 0.0684888826580888 0.476540816200841 no 1583 0.472698234824908 2232 2985126
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0669688069074413 0.477169238939426 no 1584 0.473303267957596 2265 2333 A French combination drug.
SGTC_2813 7971799 71.43 µM 0.0667584544183912 0.477256206407384 no 1585 0.473386999079506 2233 2234054
SGTC_804 1595-0054 20.9 µM 0.0645641617067114 0.478163471657049 no 1586 0.474260509981146 2159 761523 Stimulates phospholipase C.
SGTC_1607 st000305 50.6 µM 0.0641844318206179 0.478320488641601 no 1587 0.474411686720199 2273 5457690
SGTC_2243 6634756 200 µM 0.0638129173017677 0.478474111857204 no 1588 0.474559596351948 2286 885676
SGTC_1108 betulinic acid 729.144 nM 0.0627523560169002 0.478912677068642 no 1589 0.474981852719258 2286 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2843 9000894 45.46 µM 0.0623784460006377 0.479067303126671 no 1590 0.47513072956366 2308 2242070
SGTC_417 st075190 100 µM 0.0617807131152807 0.479314495015017 no 1591 0.475368731423721 2300 222757
SGTC_2406 ethylparaben 405.7 µM 0.0612336976886064 0.479540719719286 no 1592 0.475586546600569 2038 8434 A possible steroid mimic.
SGTC_1552 6-methylflavone 10.6 µM 0.0598270576802273 0.48012248243302 no 1593 0.476146687628792 2309 689013
SGTC_1872 amphotericin b 148 nM 0.0594027155168482 0.480297991604403 no 1594 0.476315675105669 2276 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1205 4161-2785 76 µM 0.0585604817061452 0.480646353275435 no 1595 0.476651093832943 2119 3498106
SGTC_1709 st033179 39.1045 µM 0.0559462397985936 0.481727739416332 no 1596 0.477692317228083 2308 573381
SGTC_1678 st019265 80.2 µM 0.0556284498459102 0.481859203159826 no 1597 0.477818899945495 2312 5367020
SGTC_3085 9117376 49.47 µM 0.0556022702951824 0.481870033237125 no 1598 0.477829327935443 2203 16480349
SGTC_3251 9135047 49.47 µM 0.0552190410885015 0.482028570790293 no 1599 0.477981979741635 2302 17682963
SGTC_3068 9116768 49.47 µM 0.0547380017214442 0.482227575311127 no 1600 0.478173596868315 2235 41904888
SGTC_1480 1070-0044 41.2 µM 0.0544945253675413 0.482328302428093 no 1601 0.478270585117117 2286 3124987
SGTC_581 0958-0271 211 µM 0.0539377343507802 0.482558653271835 no 1602 0.478492386372471 2306 4591145
SGTC_364 0083-0097 67.7 µM 0.0529411638593277 0.482970960425726 no 1603 0.478889393174598 2239 5207356
SGTC_1458 k015-0034 6.33 µM 0.0516457020673961 0.483506953849586 no 1604 0.47940550146168 2177 3598957
SGTC_2362 9071156 126 µM 0.0501666382755957 0.484118948436429 no 1605 0.479994798431771 2291 653133
SGTC_2782 7736369 71.43 µM 0.0499910456657459 0.484191606183648 no 1606 0.480064761962414 2261 2950836 YOL077C BRX1
SGTC_3184 9108758 49.47 µM 0.0495959360686411 0.484355098882167 no 1607 0.480222192597938 2301 902885
SGTC_1785 bathophenanthroline 24 µM 0.0487100166536528 0.484721693665197 no 1608 0.480575196608897 2231 72812 An iron chelator.
SGTC_2239 6685329 187.64 µM 0.0481685052195682 0.484945778288123 no 1609 0.480790975116844 2188 805680
SGTC_399 oxolinic acid 75 µM 0.0479776527155104 0.485024756725629 no 1610 0.480867026321164 2217 4628 A DNA gyrase inhibitor.
SGTC_3104 9120930 49.47 µM 0.0475741732026549 0.485191726239564 no 1611 0.481027807757422 2228 17014836
SGTC_1188 1403-0014 4.57 µM 0.0449237892958579 0.486288581955351 no 1612 0.482084027433876 2298 9614867
SGTC_1915 st067105 30.6 µM 0.0446477951077492 0.486402807666508 no 1613 0.48219402281641 2328 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2262 9014885 67.46 µM 0.0444972572618359 0.486465111233679 no 1614 0.482254019100667 2300 6457424
SGTC_2770 toltrazuril 17.5 µM 0.0444562840891629 0.486482068985533 no 1615 0.482270348871978 2324 68591 Kills coccidiodes.
SGTC_1650 st011916 45.8 µM 0.0436075783940065 0.486833332092796 no 1616 0.482608605380547 2324 242528
SGTC_949 1165-0505 146 µM 0.0425512356199906 0.487270546467249 no 1617 0.483029634294664 2282 6244267
SGTC_3241 9133421 49.47 µM 0.0411212973929584 0.487862414187947 no 1618 0.483599598048811 2327 17018221
SGTC_164 4100-3994 89.624 µM 0.0403800570297391 0.48816923262069 no 1619 0.483895064732402 2341 4615967
SGTC_983 1491-0821 12.2 µM 0.0401694002800064 0.488256430147925 no 1620 0.483979036485394 2323 46495113
SGTC_2258 7960471 200 µM 0.0398833340941333 0.488374842936627 no 1621 0.484093068998628 2208 2974708
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0396222105868886 0.488482931974118 no 1622 0.48419715992672 2330 15053
SGTC_1578 josamycin 24.2 µM 0.0389162161638012 0.488775174363655 no 1623 0.484478593866724 2262 5282165 A P450 substrate.
SGTC_162 k030-0015 37.8 µM 0.0387988505197514 0.48882375779518 no 1624 0.484525380649173 2329 1809920 YMR134W ERG29
SGTC_582 0987-0078 156 µM 0.0386468145562374 0.488886693229203 no 1625 0.484585988766408 2338 1625765
SGTC_1046 2001-0062 216 µM 0.0383291536454249 0.489018190161479 no 1626 0.484712623305837 2317 739778
SGTC_85 0868-0259 160.055 µM 0.0377945311634325 0.489239501842346 no 1627 0.48492575237904 2288 83173
SGTC_2971 9092186 9.93 µM 0.0373929488402584 0.489405742561499 no 1628 0.485085847375489 2286 25236400
SGTC_2296 7971656 126.45 µM 0.0362608976636917 0.489874381073447 no 1629 0.485537164282506 2300 666570
SGTC_1699 st031318 29.054 µM 0.0362049887888467 0.489897526200223 no 1630 0.485559454060423 2315 5340658
SGTC_1970 st070122 35.8 µM 0.0358667118772557 0.490037566622013 no 1631 0.48569431942696 2316 102928
SGTC_2166 5933061 31.504 µM 0.0356793043733701 0.490115150412681 no 1632 0.485769036380572 2306 2877375
SGTC_260 nsc-65238 3.989 µM 0.0341414064635469 0.490751830079766 no 1633 0.486382195067152 2333 3246252
SGTC_2031 5180455 200 µM 0.0337365617393979 0.490919437129572 no 1634 0.486543611752456 2347 29949
SGTC_1388 3346-4487 254 µM 0.0334984626660485 0.49101801168118 no 1635 0.486638545880065 2313 3345614
SGTC_1956 st077085 54 µM 0.0329478258157853 0.491245980978833 no 1636 0.486858096996797 2315 24208685
SGTC_791 1348-1292 225 µM 0.0315990923652778 0.491804382373894 no 1637 0.487395883608656 2330 5437054
SGTC_3031 9088762 49.47 µM 0.0315463521636979 0.49182621815756 no 1638 0.487416913420683 2355 205253
SGTC_169 k015-0017 16.025 µM 0.0310049240434214 0.492050384562661 no 1639 0.487632806371677 2321 1840002
SGTC_265 mycophenolic acid 32.932 µM 0.0299797674729768 0.492474834913077 no 1640 0.488041594567397 2334 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1948 st076329 66.6 µM 0.0290041071450707 0.492878800024094 no 1641 0.488430657472817 2360 24208413
SGTC_1072 oxiconazole 14.9 nM 0.0288930816941316 0.492924769780638 no 1642 0.488474931664133 2354 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2403 6032726 181.2 µM 0.028823363437987 0.492953636464548 no 1643 0.488502733645106 2320 2881040
SGTC_654 1124-0271 80.9 µM 0.0275995963576496 0.493460340287574 no 1644 0.48899075180193 2331 5403748
SGTC_2619 obliquin 87.91 µM 0.027453589068085 0.49352079569191 no 1645 0.489048978219287 2339 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2928 9011484 9.79 µM 0.0271339820435779 0.493653131875333 no 1646 0.489176435490398 2325 2994751
SGTC_2376 9072922 81.32 µM 0.0266168942961622 0.493867238213707 no 1647 0.489382649166821 2322 17087968
SGTC_1491 4138-0063 26.5 µM 0.0264368842675212 0.493941773927018 no 1648 0.489454437515737 2367 23883227
SGTC_1460 k062-0059 9.15 µM 0.0260296185856045 0.494110408853213 no 1649 0.489616857117628 2326 1373085
SGTC_3134 9127454 49.47 µM 0.0257226158572286 0.494237528983278 no 1650 0.489739292489097 2364 24262820
SGTC_3043 9092303 49.47 µM 0.0257198050471366 0.494238692853653 no 1651 0.489740413469214 2355 25236084
SGTC_176 1486-1328 72.834 µM 0.0252976637282602 0.49441348919637 no 1652 0.489908768705457 2330 22310231
SGTC_2738 aclarubicin 5.55 µM 0.0249111335816736 0.494573540938318 no 1653 0.490062923338465 2351 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3320 9137005 35.139 µM 0.0247465596703653 0.494641686837101 no 1654 0.490128558595608 2256 4908713
SGTC_158 k038-0087 26.446 µM 0.0239032340684256 0.494990889073297 no 1655 0.490464897303773 2299 X158
SGTC_2374 9071832 200 µM 0.0235878210222548 0.495121495549168 no 1656 0.490590693433081 2368 17381698
SGTC_1529 apigenin 74 µM 0.0231867478446239 0.495287572991325 no 1657 0.490750654727498 2359 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2906 7926292 26.41 µM 0.0227879203889343 0.495452721328955 no 1658 0.490909721828629 2329 2966319
SGTC_2641 levomentholum 100 µM 0.0226667711420862 0.495502887531163 no 1659 0.490958040904614 2347 16666
SGTC_1267 0828-0272 9.49 µM 0.0220984238835004 0.495738233087825 no 1660 0.491184721864462 2356 745334
SGTC_2749 bexarotene 57.39 µM 0.0214257709225386 0.496016772253343 no 1661 0.491453008029375 2341 82146 An retinoic acid receptor inhibitor.
SGTC_2006 4011487 200 µM 0.0210396493344133 0.496176662400486 no 1662 0.491607013536389 2358 45595294
SGTC_3314 9135860 59.4275 µM 0.0195488857593345 0.496793982310209 no 1663 0.492201619642482 2367 25252478
SGTC_248 streptozotocin 5.23457 mM 0.0194786933945508 0.49682304892036 no 1664 0.492229617013511 2366 5300 DNA alkylating agent.
SGTC_1006 4099-6547 255 µM 0.0193349781477688 0.496882561358007 no 1665 0.492286940306025 2354 3146833
SGTC_14 0354-0009 295 µM 0.0177482536849334 0.497539627766469 no 1666 0.492919842912588 2374 1713507
SGTC_1514 1189-1591 158 µM 0.0167968325198161 0.49793361686949 no 1667 0.493299348412312 2370 767698 YMR146C TIF34
SGTC_1838 st055369 84.5 µM 0.0160200277155363 0.498255297821942 no 1668 0.493609206969131 2377 676036
SGTC_3317 9138495 8.753 µM 0.0151431442744472 0.498618423473816 no 1669 0.493958990373758 2377 17020139
SGTC_2846 9008642 19.48 µM 0.0146893359364264 0.498806350228558 no 1670 0.494140013566012 2338 2992898
SGTC_304 1310-0298 97 µM 0.0146614638790508 0.498817892346591 no 1671 0.494151131710834 2380 1550234
SGTC_1347 1493-0251 600 nM 0.014313684794919 0.498961911477168 no 1672 0.494289860931345 2381 3986378
SGTC_103 0844-0104 51.839 µM 0.0138063371462253 0.499172009936773 no 1673 0.494492243352239 2379 5375804
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0134707918064187 0.499310963226582 no 1674 0.494626094125252 2339 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1483 3453-0561 55.9 µM 0.0134657308792571 0.499313059016999 no 1675 0.494628112959964 2378 4546991
SGTC_2997 9067075 71.4286 µM 0.0126524007073384 0.49964986896697 no 1676 0.494952557078127 2360 27209819
SGTC_114 0364-0001 490.298 µM 0.012345796900304 0.499776837422929 no 1677 0.495074864745324 2341 4003655
SGTC_3083 9117465 49.47 µM 0.0122998725016747 0.499795855290757 no 1678 0.495093184538634 2332 16420915
SGTC_2255 7941087 197.44 µM 0.0113139342089315 0.499795855290757 no 1679 0.495486489578647 2396 935561
SGTC_2576 guaiol 23.12 µM 0.0109077168832012 0.499627635636812 no 1680 0.495648536841086 2384 227829
SGTC_2463 5473429 200 µM 0.0105244060017193 0.499468901886922 no 1681 0.49580144697742 2318 5399405
SGTC_1909 st060837 51.5 µM 0.00906041636910958 0.498862646767414 no 1682 0.496385466285924 2374 678937
SGTC_1106 tegaserod maleate 11.7 µM 0.00886859577821053 0.498783211796195 no 1683 0.49646198855495 2335 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1336 1486-0901 104 µM 0.00869571877878734 0.498711621611335 no 1684 0.496530953839674 2343 5006114
SGTC_1414 3917-0015 5.4 µM 0.00854940001295986 0.498651029502838 no 1685 0.496589324411803 2386 6618702
SGTC_810 3825-7150 143 µM 0.00840952865624207 0.498593107361955 no 1686 0.496645123003737 2389 22330411 YGL099W LSG1
SGTC_2600 tangeritin 87.95 µM 0.00687308276255061 0.497956851825918 no 1687 0.497258058277223 2396 68077 A bioactive flavone.
SGTC_2628 lathosterol 100 µM 0.00608640654130092 0.497631084307078 no 1688 0.497571890086263 2390 6710616
SGTC_439 amiodarone 34.4 µM 0.00450324463201871 0.496975492118607 no 1689 0.49820347138933 2367 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_270 tamoxifen 5.46 µM 0.00308928013883649 0.496389971949488 no 1690 0.498767557496948 2398 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1994 st072947 40.9 µM 0.00306687195158288 0.496380692818469 no 1691 0.498776497027921 2380 5286565 YDL195W SEC31
SGTC_2407 paclitaxel 400 µM 0.00233233326163695 0.496076524716322 no 1692 0.499069534493534 2378 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_667 1498-1044 59 µM 0.000875525477067482 0.49547327619763 no 1693 0.499650715914253 2401 6739982
SGTC_2904 7225135 42.03 µM 0.000752719610402355 0.495422424055843 no 1694 0.49969970835048 2396 4446116
SGTC_1752 st044819 83.042 µM 0.000516182805764759 0.495324477779951 no 1695 0.499794072863509 2403 441209 YML126C ERG13
SGTC_3014 9081533 49.47 µM 0 0.495110735355465 no 1696 0.5 2406 21367265
SGTC_2485 5633444 17.78 µM -3.13307255589037e-05 0.495097761885284 no 1697 0.499987500848901 2406 5724239
SGTC_1735 st034310 56.75 µM -0.00142427798386227 0.494520973797962 no 1698 0.499431795485299 2428 871153
SGTC_1015 4130-4525 82 µM -0.00152657813366872 0.494478614046775 no 1699 0.499390983674689 2412 1363237
SGTC_1341 1486-1360 280 µM -0.00170061664380571 0.494406549505914 no 1700 0.499321552445054 2408 3976547
SGTC_343 4130-2827 29.8 µM -0.00313510454103832 0.493812574851065 no 1701 0.498749276293971 2412 1118244
SGTC_822 1487-0950 154 µM -0.00372358636160941 0.493568907614745 no 1702 0.498514507398378 2409 1958375
SGTC_2172 5754775 163.918 µM -0.00437083736450113 0.493300909139945 no 1703 0.498256293726568 2411 2263357
SGTC_1997 st073024 93.8 µM -0.00592246338764589 0.492658460865618 no 1704 0.497637292762765 2415 686268
SGTC_306 1672-3436 11.6 µM -0.00603900389482173 0.492610208203044 no 1705 0.497590800658599 2418 6797378
SGTC_2396 5342950 42.78 µM -0.00616492378254253 0.492558072204716 no 1706 0.497540566826688 2425 1886677
SGTC_315 k915-0449 187 µM -0.00711856925003632 0.492163228056397 no 1707 0.49716012573486 2425 20970215 YNL149C PGA2
SGTC_3167 9103034 49.47 µM -0.00719689167718847 0.492130800039152 no 1708 0.497128880407581 2416 5127859
SGTC_1932 st074806 40.9 µM -0.00726144193493072 0.492104074184423 no 1709 0.497103129253459 2503 17251235
SGTC_307 1501-1223 22.3 µM -0.00920894726695931 0.491297762402487 no 1710 0.496326213503029 2425 2830329
SGTC_1879 gemcitabine 100 µM -0.00949454754014698 0.491179520263426 no 1711 0.496212280461274 2426 60750 A nucleoside analog which inhibits DNA replication.
SGTC_692 k241-0027 77.8 µM -0.0095608816399423 0.491152057214476 no 1712 0.496185818185353 2425 3600480
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.00985696607293584 0.491029475506802 no 1713 0.496067703153976 2427 551469
SGTC_775 4577-0580 57.3 µM -0.0109715233010141 0.490568046146171 no 1714 0.49562308328639 2467 2006902
SGTC_1277 0873-0036 22 µM -0.0111539419789684 0.490492525562418 no 1715 0.495550313216205 2438 5965735
SGTC_1540 guanosine 70.6 µM -0.0123272267822562 0.490006798733768 no 1716 0.495082272586846 2421 6802 Guanosine is a purine nucleoside
SGTC_2937 9044753 11.33 µM -0.0123486807841988 0.489997917151911 no 1717 0.495073714329803 2433 6465530 YGL099W LSG1
SGTC_1021 4476-0760 85.3 µM -0.0139537679866922 0.489333453474348 no 1718 0.494433432621983 2435 746768
SGTC_2653 dihydrofissinolide 100 µM -0.0141493646936762 0.489252483594132 no 1719 0.494355408528957 2446 6857746
SGTC_2883 9059145 45.46 µM -0.015245075738912 0.488798907596387 no 1720 0.49391833029658 2429 16476510
SGTC_428 3448-4153 16.5 µM -0.015651850659021 0.488630524394259 no 1721 0.493756069946739 2429 3834874
SGTC_61 0978-8327 98.565 µM -0.0190427273053958 0.487226963354048 no 1722 0.492403510059945 2434 6150059 YHR072W ERG7
SGTC_2326 6164455 177.58 µM -0.0191559694020135 0.487180092505346 no 1723 0.492358341238914 2462 2888790
SGTC_1172 0370-0043 85 µM -0.0192580647456635 0.487137835444049 no 1724 0.492317618601895 2465 376585
SGTC_1053 3366-3204 134 µM -0.0194921723585489 0.487040939310967 no 1725 0.492224240705617 2448 3632071 YPR165W RHO1
SGTC_52 0329-0193 875 nM -0.0195618619663212 0.487012095229844 no 1726 0.49219644387461 2486 3739292
SGTC_2294 7971431 200 µM -0.0200050983326968 0.486828644140725 no 1727 0.492019652749477 2467 5741572
SGTC_2591 skatole 100 µM -0.0202053479272702 0.486745763752524 no 1728 0.49193978086424 2459 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1054 3429-0080 167 µM -0.0202345215713468 0.486733689254189 no 1729 0.491928144643098 2446 1162877
SGTC_226 1,3-diallylurea 8.28947 mM -0.0213761872999978 0.486261181977829 no 1730 0.49147278450347 2486 74537 YKL182W FAS1
SGTC_425 3825-7017 13.1 µM -0.0247159221391542 0.484879061308607 no 1731 0.490140777464864 2587 3397440
SGTC_237 nikkomycin 200 µM -0.0247452021230279 0.484866944816947 no 1732 0.490129100012843 2453 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2890 9046729 58.44 µM -0.0250394363169908 0.484745187120444 no 1733 0.490011753914025 2465 903329
SGTC_1234 0326-0494 15.5 µM -0.0251062972172673 0.484717519462718 no 1734 0.48998508865686 2482 1547813
SGTC_3324 9138759 60.749 µM -0.0256162071986671 0.484506516435391 no 1735 0.489781729418431 2514 45595710
SGTC_209 4077-0173 175.592 µM -0.0257311086220542 0.484458970310143 no 1736 0.489735905487196 2504 15993494
SGTC_3037 9091026 49.47 µM -0.0258488520040594 0.48441024841373 no 1737 0.489688948292657 2458 25236398 YIL048W NEO1
SGTC_361 000s-0510 1.45 µM -0.0260122826517979 0.484342621634919 no 1738 0.489623770813601 2474 660
SGTC_1766 st045414 44.774 µM -0.0261538036595332 0.484284061318569 no 1739 0.489567331301972 2454 253960
SGTC_2401 5128683 200 µM -0.0268877987900791 0.483980345184078 no 1740 0.489274612577742 2474 708373
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0270685466543138 0.483905555858482 no 1741 0.489202530848805 2497 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1626 st003712 1.76 µM -0.0272603172576714 0.483826206195101 no 1742 0.48912605366881 2478 24207035
SGTC_1873 rapamycin 2 nM -0.0281012153059473 0.483478272165495 no 1743 0.48879071239174 2476 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1158 4092-0494 91.8 µM -0.0285918013109836 0.483275290729358 no 1744 0.488595075509427 2527 1148199
SGTC_3209 9113616 49.47 µM -0.0286048982759657 0.483269871879849 no 1745 0.488589852712561 2466 16649353
SGTC_1361 1608-0041 5.61 µM -0.0289634647017122 0.483121516765842 no 1746 0.488446864652919 2458 X1361
SGTC_2176 5809774 33.9695 µM -0.0290521237213853 0.483084834887378 no 1747 0.488411509699325 2476 2870539
SGTC_2478 5763493 32.33 µM -0.0300426606935494 0.482675018859045 no 1748 0.488016515099307 2472 1365576 YLR208W SEC13
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0305675039113232 0.482457882247694 no 1749 0.487807229077558 2458 688662
SGTC_2381 9035592 200 µM -0.0310649642638621 0.482252079197925 no 1750 0.487608865321622 2488 4749657
SGTC_3245 9134821 49.47 µM -0.0313713224504924 0.482125338885888 no 1751 0.487486705629748 2447 17014901
SGTC_650 1328-0195 38 µM -0.0324240302433296 0.481689847759264 no 1752 0.487066949598831 2457 2780821
SGTC_1058 3448-5425 97.3 µM -0.0328419899210216 0.481516949464087 no 1753 0.486900296572253 2463 7279705
SGTC_2744 captopril 92.04 µM -0.0331504245840435 0.481389360849148 no 1754 0.486777315910724 2476 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1665 st014639 11.4 µM -0.0344697341730598 0.480843630367628 no 1755 0.486251288315511 2471 981133 YIL048W NEO1
SGTC_392 N-ethylmaleimide 8.33 µM -0.0347596811673048 0.48072369899384 no 1756 0.486135685477973 2485 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_328 k915-0120 63.5 µM -0.0356242356123688 0.480366101954062 no 1757 0.485790991680099 2506 6624543
SGTC_1307 1187-1599 12.2 µM -0.03648766659773 0.480008985368811 no 1758 0.485446756395631 2479 1538471
SGTC_1790 st045711 43.5 µM -0.037616555379664 0.479542099215749 no 1759 0.484996703989813 2479 585119
SGTC_1263 0774-1208 64.8 µM -0.0385135303025612 0.479171148043676 no 1760 0.484639121933262 2487 906585
SGTC_2671 danthron 100 µM -0.0385462307384694 0.479157624855074 no 1761 0.484626086026622 2491 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2970 9090938 41.86 µM -0.0389758440429742 0.478979961514269 no 1762 0.484454823818597 2481 17217104
SGTC_40 0327-0103 19.753 µM -0.0389969893527845 0.478971217138482 no 1763 0.484446394468972 2493 409036
SGTC_1207 2099-0101 141 µM -0.0400747331517642 0.478525543300977 no 1764 0.48401677281957 2482 5837381
SGTC_3263 9137018 49.47 µM -0.0406586731308518 0.478284080791273 no 1765 0.483784004198103 2489 43844957
SGTC_382 3229-0966 23.2 µM -0.0414397182440032 0.477961126661342 no 1766 0.48347267469878 2503 5722370
SGTC_1211 1056-0033 32.3 µM -0.0416404785930759 0.47787811664908 no 1767 0.483392651980027 2501 6741922
SGTC_1194 1488-0194 225 µM -0.0419082411274003 0.477767404193293 no 1768 0.483285923350849 2471 1391452
SGTC_1164 k060-0068 93.7 µM -0.0419306638167886 0.477758133104645 no 1769 0.483276985848134 2471 5963676
SGTC_259 usnic acid 108.925 µM -0.0423737770160112 0.477574921975621 no 1770 0.48310036623884 2533 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2902 5787006 60.46 µM -0.0427302235922531 0.477427547768619 no 1771 0.482958293311653 2489 591003
SGTC_1792 st045773 43.6 µM -0.0431685537646455 0.477246322708191 no 1772 0.482783586085682 2489 2919270
SGTC_725 1497-0963 19 µM -0.0444783696375365 0.476704815139656 no 1773 0.482261546719687 2484 3549977
SGTC_2555 cholic acid 100 µM -0.0446504000598474 0.476633697038288 no 1774 0.482192984626234 2616 6708657 Influences liver metabolism.
SGTC_2107 5363541 170.161 µM -0.0466064826619083 0.475825097142125 no 1775 0.481413432614959 2481 244052
SGTC_2688 kanamycin b 96.69 µM -0.047543230833815 0.475437901877185 no 1776 0.481040138024235 2510 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1295 1013-0063 9.78 µM -0.047813603557759 0.475326150377532 no 1777 0.480932397442776 2503 6826038
SGTC_739 1486-1183 203 µM -0.0481316615967134 0.475194691884445 no 1778 0.480805656566933 2477 4346692
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0483669532051272 0.475097443822611 no 1779 0.480711897994645 2507 1273210
SGTC_1628 st004252 77.7 µM -0.0487818611313057 0.47492596239751 no 1780 0.480546568841539 2526 692968
SGTC_2863 9028737 58.44 µM -0.0500679731039856 0.47439444203842 no 1781 0.480034110738067 2534 6460917
SGTC_441 propafenone 146 µM -0.0512550176362254 0.473903904384621 no 1782 0.479561155842747 2483 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3053 9095903 49.47 µM -0.0517194871542844 0.473711976410038 no 1783 0.479376104757722 2506 17174018
SGTC_3258 9138477 49.47 µM -0.0517623101770079 0.473694281398166 no 1784 0.479359043695936 2508 4970355
SGTC_2914 7968218 45.32 µM -0.0518786496052762 0.473646208744539 no 1785 0.479312693254807 2540 2977111
SGTC_2950 9072895 21.46 µM -0.0519884874343853 0.473600822971047 no 1786 0.479268933352936 2532 17332245
SGTC_490 phenamil 164 µM -0.0521041100157979 0.473553047266918 no 1787 0.479222869048826 2523 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1229 0139-0193 12.2 µM -0.052765030364836 0.473279959709105 no 1788 0.478959562197155 2503 3090752
SGTC_2544 sphondin 68.51 µM -0.0540115642543335 0.472764935107443 no 1789 0.478462975374592 2547 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2222 6885208 172.143 µM -0.0543890448240464 0.472608982160124 no 1790 0.478312603450258 2512 609514
SGTC_3081 9117243 49.47 µM -0.0543995579356517 0.472604638815784 no 1791 0.478308415525616 2579 45595589
SGTC_557 1315-0110 16.2 µM -0.0547430156825874 0.472462745868072 no 1792 0.478171599581924 2508 6833801
SGTC_2069 5228469 200 µM -0.0567256738850086 0.471643717719037 no 1793 0.477381861068738 2573 2835210
SGTC_567 1080-0542 68.4 µM -0.0568131636878885 0.471607578769383 no 1794 0.477347013884718 2508 5950415
SGTC_784 4579-0127 173 µM -0.0578647546302322 0.471173222043561 no 1795 0.476928178895298 2669 1948547
SGTC_2797 7859098 81.82 µM -0.0580865925700034 0.47108159685935 no 1796 0.476839826970052 2528 972681
SGTC_2874 9043904 71.43 µM -0.0585111659935786 0.470906240604274 no 1797 0.476670734278501 2578 4463428
SGTC_1510 1123-0200 71.5 µM -0.0604808625212604 0.470092795789351 no 1798 0.475886328719801 2571 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1490 4089-0339 670 nM -0.0622921497832779 0.469344880854659 no 1799 0.475165089951605 2516 742542
SGTC_1132 3456-3614 2.5 µM -0.0626514223562144 0.469196543151432 no 1800 0.475022040346937 2609 3125502
SGTC_2043 5101342 149 µM -0.0632654766166236 0.468943020213489 no 1801 0.474777553169331 2548 678451
SGTC_1068 loratadine 26.9 µM -0.0635458918012538 0.468827250129309 no 1802 0.474665908343965 2557 3957 A H1 histamine antagonist.
SGTC_1902 st060212 70.5 µM -0.0636057136961918 0.468802552856737 no 1803 0.474642091042822 2518 688944
SGTC_1941 st076221 61.8 µM -0.063682851255476 0.46877070704631 no 1804 0.474611379871307 2576 2828568
SGTC_1925 st057770 10.1 µM -0.06594087728689 0.467838582993918 no 1805 0.473712448008371 2522 5989122
SGTC_1983 st071813 46.9 µM -0.0659507258205 0.467834517854138 no 1806 0.473708527545938 2584 11838595
SGTC_2570 licareol 100 µM -0.0662268936055612 0.467720526550766 no 1807 0.473598592885186 2609 443158
SGTC_2329 6138490 200 µM -0.0665152179468669 0.467601520318933 no 1808 0.47348382118535 2745 720019
SGTC_714 4296-0578 26.1 µM -0.066754717286536 0.467502668868672 no 1809 0.473388486661055 2561 1589775
SGTC_2102 5377816 72.7585 µM -0.0672425033234831 0.46730134525992 no 1810 0.473194324457434 2580 1379702
SGTC_2791 5663188 71.43 µM -0.0689058582673311 0.466614893074547 no 1811 0.472532277691207 2599 54690634
SGTC_1292 0kpi-0043 232 µM -0.0695565941605347 0.466346366914154 no 1812 0.472273293030783 2556 3333905
SGTC_1762 st045503 25.4615 µM -0.0698632504467272 0.466219830503425 no 1813 0.472151251761824 2573 4645554
SGTC_1756 st041558 35.5 µM -0.0704245177504111 0.465988242114945 no 1814 0.471927888674717 2562 3955792
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0706184809295396 0.465908212298299 no 1815 0.471850700739361 2511 6708784 An antioxidant flavonoid
SGTC_920 mycophenolic acid 780.421 nM -0.071067390442071 0.465722996117133 no 1816 0.471672060591722 2555 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_870 0573-2213 57.6 µM -0.0721111165411592 0.465292392524945 no 1817 0.471256739769213 2529 3916321
SGTC_1737 st035557 69.7 µM -0.0723883231581738 0.465178033922194 no 1818 0.471146438592937 2521 5716916
SGTC_3345 9148410 3.559 µM -0.0749147423068336 0.464135920641219 no 1819 0.470141273427158 2566 4903596
SGTC_1698 5-fluorocytosine 1.055 µM -0.0754668179266382 0.463908229516108 no 1820 0.469921648842194 2545 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2094 5332512 191.667 µM -0.0757653506075089 0.463785111371275 no 1821 0.469802891534738 2620 755774
SGTC_1031 k035-0009 16 µM -0.0771481356435405 0.463214881109622 no 1822 0.469252850184695 2608 5180959
SGTC_467 ro 31-8220 72.8 µM -0.0787742408650869 0.462544407709738 no 1823 0.46860609658701 2603 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2833 9001315 45.46 µM -0.0795322198732626 0.462231915122568 no 1824 0.468304652509633 2603 2989378
SGTC_121 0557-0495 61.343 µM -0.0801118335789583 0.461992973053295 no 1825 0.468074155582302 2559 3104427
SGTC_452 diindolylmethane 8 µM -0.0801930328827401 0.46195950024939 no 1826 0.46804186563563 2612 3071 Inhibits expression of several cancer promoting factors.
SGTC_3193 9111931 49.47 µM -0.0817785974059715 0.461305936983565 no 1827 0.467411387926453 2572 17087244
SGTC_1187 1391-0724 117 µM -0.0823271192032221 0.461079862760365 no 1828 0.467193294804339 2591 6997986
SGTC_1649 st011737 51.3 µM -0.0823344899535774 0.461076824978125 no 1829 0.467190364249414 2593 1761035
SGTC_3233 9132340 49.47 µM -0.0831153040990817 0.460755033009466 no 1830 0.466879928520139 2549 17682950
SGTC_3235 9132602 49.47 µM -0.0844519305821175 0.46020423739842 no 1831 0.466348560041374 2637 4912240
SGTC_2132 5317594 122.667 µM -0.0846676740614452 0.460115341185447 no 1832 0.466262798009379 2565 794577
SGTC_1656 st012921 11 µM -0.0861399138152166 0.459508764302677 no 1833 0.46567759744395 2610 6732821
SGTC_3007 9078383 71.4286 µM -0.0862665351295419 0.459456599489352 no 1834 0.465627270186733 2590 6496995
SGTC_3229 9132204 49.47 µM -0.0869928727789081 0.4591573800643 no 1835 0.465338588664678 2566 17682924
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0872116325341172 0.459067265114237 no 1836 0.465251646581785 2703 165506
SGTC_2882 9058044 58.44 µM -0.0878570301526608 0.458801415076205 no 1837 0.464995154726788 2630 18076804
SGTC_369 0957-0393 4.5 µM -0.0883639340466663 0.458592625824579 no 1838 0.464793712796017 2596 6997992
SGTC_766 1391-0721 126 µM -0.0884214040898909 0.458568955139575 no 1839 0.464770874959444 2671 1020919 YIL115C NUP159
SGTC_2743 auranofin 4.32 µM -0.0896384012111523 0.458067734610248 no 1840 0.464287283735449 2595 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1990 st072050 59.8 µM -0.090326709786126 0.457784284040412 no 1841 0.464013797781303 2546 17233948
SGTC_2708 st078559 56 µM -0.0908604866008592 0.457564485567447 no 1842 0.463801723699381 2568 17250902
SGTC_1085 doxorubicin 7.67 µM -0.0909392760853951 0.457532042752367 no 1843 0.463770420834744 2579 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3153 9100258 49.47 µM -0.0913048121988016 0.457381531187809 no 1844 0.463625197190598 2607 25236848
SGTC_3327 9140648 26.9345 µM -0.0916472340771562 0.45724054258492 no 1845 0.463489160984741 2590 8029710
SGTC_2277 7947813 106.88 µM -0.0922511306959266 0.456991907636184 no 1846 0.463249257391463 2800 1246798
SGTC_479 n-linoleoylglycine 10 µM -0.0924722808683096 0.456900860394032 no 1847 0.463161406750895 2578 6433346 An anti-infammatory.
SGTC_1260 0700-1617 7.75 µM -0.0925805494912202 0.456856287165551 no 1848 0.463118398314754 2626 2853078
SGTC_3065 9113888 49.47 µM -0.0926579943076835 0.456824404156821 no 1849 0.463087634537371 2680 16648368
SGTC_1371 2421-0008 32.7 µM -0.0943027939180326 0.456147327825755 no 1850 0.462434315291176 2637 2827552
SGTC_1383 3049-0032 20.7 µM -0.0947603664740758 0.455958992145606 no 1851 0.462252584065619 2671 712864
SGTC_599 1935-0052 86.5 µM -0.0953773349975867 0.455705065171369 no 1852 0.46200755902422 2581 9557311
SGTC_1907 st060210 83.7 µM -0.0953856811647689 0.455701630246381 no 1853 0.462004244496771 2600 688793
SGTC_2354 9060492 162 µM -0.0955757037543462 0.455623425982617 no 1854 0.461928781219694 2658 6471895
SGTC_2254 7938975 95.19 µM -0.0964354970762988 0.455269597462543 no 1855 0.461587350449525 2741 2969277
SGTC_2055 5235184 200 µM -0.0969885640590665 0.455042013972923 no 1856 0.46136773809526 2673 2836034
SGTC_2811 7967822 32.47 µM -0.0979682403906238 0.454638919755488 no 1857 0.460978756258293 2670 2232244
SGTC_2965 9082772 38.63 µM -0.098187853417429 0.454548564937111 no 1858 0.460891563712639 2629 16459634
SGTC_1661 st013063 9.66 µM -0.0987545740719159 0.454315411403277 no 1859 0.460666568376653 2580 721395
SGTC_2693 st077581 40.7 µM -0.0991366735798827 0.454158221405233 no 1860 0.460514877095675 2577 25238761
SGTC_694 1315-0438 43.2 µM -0.0991727735806074 0.454143370778023 no 1861 0.460500545902212 2626 6793154
SGTC_2877 9040724 71.43 µM -0.100251598117773 0.453699599326287 no 1862 0.460072291466611 2591 6463895
SGTC_3242 9133940 49.47 µM -0.100586356434506 0.453561909155368 no 1863 0.459939413879657 2737 17248444
SGTC_3238 9133470 49.47 µM -0.102072222768557 0.452950821844153 no 1864 0.459349674426617 2621 3534688
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.10285120809682 0.452630495557825 no 1865 0.45904053127241 2573 66535 A nucleotide analog.
SGTC_1799 st045822 46.1415 µM -0.1029334322667 0.452596685980521 no 1866 0.459007901754108 2590 3674992
SGTC_105 0111-0055 734.78 µM -0.103176115072404 0.452496899771391 no 1867 0.458911598068953 2677 5179370
SGTC_3147 9097027 49.47 µM -0.103792837282336 0.452243329719223 no 1868 0.458666875394546 2629 25236841
SGTC_1950 st077106 7.18 µM -0.104552686283046 0.451930938786673 no 1869 0.458365379864266 2668 13831864
SGTC_1447 4239-0816 81.9 µM -0.106177143951124 0.451263187939486 no 1870 0.457720902454012 2598 1341554
SGTC_1520 flindersine 88 µM -0.107158327365963 0.450859928587171 no 1871 0.457331687476056 2872 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3281 9140613 49.47 µM -0.108310906822134 0.450386291499196 no 1872 0.456874535561253 2626 16013766
SGTC_2371 9071574 200 µM -0.110006518774502 0.449689631091496 no 1873 0.456202102530065 2584 45596039
SGTC_2689 tacrolimus 100 µM -0.110242932166573 0.449592510372639 no 1874 0.456108357404373 2698 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_509 pifithrin 175 µM -0.111059912148407 0.449256911030919 no 1875 0.455784418748794 2607 4817 A p53 inhibitor.
SGTC_1055 3448-0672 86 µM -0.111110288196757 0.449236218724588 no 1876 0.45576444522976 2729 748378
SGTC_3341 9147222 25.867 µM -0.112559129138141 0.448641156704867 no 1877 0.45519004464005 2719 1939759
SGTC_2213 7173844 200 µM -0.11518272624074 0.447563898548834 no 1878 0.454150145002957 2625 892728
SGTC_3185 9108267 49.47 µM -0.115784377169782 0.44731691278799 no 1879 0.453911716222429 2656 4910486
SGTC_1487 3970-0795 2.82 µM -0.116281758014948 0.447112746713028 no 1880 0.453714621262845 2680 3765103
SGTC_82 0054-0107 293.755 µM -0.11680400014066 0.44689839060435 no 1881 0.453507686899652 2702 3104697
SGTC_3290 9121031 71.43 µM -0.116982944246579 0.446824945934856 no 1882 0.453436784596098 2644 17014854
SGTC_2398 5228213 48.84 µM -0.117199303716935 0.446736147179366 no 1883 0.453351059335503 2650 80771 YMR134W ERG29
SGTC_637 1181-0519 7.26 µM -0.117901303948116 0.446448049029018 no 1884 0.453072930027312 2615 6252091 YGR060W ERG25
SGTC_2848 9016370 25.97 µM -0.117926547725164 0.446437689607178 no 1885 0.453062928985272 2619 7894410
SGTC_1218 1348-1416 30.7 µM -0.118169804199164 0.44633786504022 no 1886 0.452966557523917 2606 6787668
SGTC_627 1391-0720 175 µM -0.119735918730631 0.445695264131377 no 1887 0.452346173000653 2686 997839
SGTC_2818 7996756 12.99 µM -0.120021490298809 0.445578105045148 no 1888 0.452233062108289 2611 2241621
SGTC_3344 9148862 3.898 µM -0.120680668375825 0.445307687667693 no 1889 0.451971985735937 2726 4905352
SGTC_1014 4130-3005 69.3 µM -0.121128576149787 0.445123955101271 no 1890 0.451794597661363 2631 743608
SGTC_659 k018-0002 107 µM -0.12133130019436 0.445040801209702 no 1891 0.451714314589781 2673 6797879 YHR007C ERG11
SGTC_10 0279-0212 42.575 µM -0.122707801272593 0.444476248450972 no 1892 0.451169243017385 2646 39851 YBR002C RER2
SGTC_976 1348-1067 47.6 µM -0.12343495469241 0.444178061986091 no 1893 0.450881339432404 2621 5310671 YGL099W LSG1
SGTC_2084 5306078 60.6385 µM -0.125810691992684 0.443204055813857 no 1894 0.449940889020842 2704 679340
SGTC_2922 7999257 32.47 µM -0.12596567399011 0.44314052806071 no 1895 0.44987954814034 2618 2988377
SGTC_1240 0356-0016 42.1 µM -0.12616101265947 0.443060460025262 no 1896 0.449802236053969 2706 4305613
SGTC_2078 5212016 200 µM -0.126237719464692 0.44302901904605 no 1897 0.449771877183229 2593 1899708
SGTC_245 methotrexate 289.6 µM -0.127109901687733 0.442671549793627 no 1898 0.449426707310035 2691 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1545 lovastatin 49.4 µM -0.127433585891229 0.442538897687917 no 1899 0.449298617613327 2674 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3132 9126706 49.47 µM -0.127695789479742 0.442431446260467 no 1900 0.449194861161174 2850 850858
SGTC_560 2332-1943 155 µM -0.128184612668803 0.442231137090538 no 1901 0.449001438459713 2624 21177716
SGTC_3259 9138485 49.47 µM -0.128458289767285 0.442118996580927 no 1902 0.448893152315698 2800 17646153
SGTC_1944 st076371 56.9 µM -0.129391580728324 0.441736611045826 no 1903 0.448523904642775 2633 24208455
SGTC_1622 st003707 19.4 µM -0.129926470507096 0.441517481854619 no 1904 0.448312300679827 2742 10140899
SGTC_2382 9035899 200 µM -0.130297983652397 0.441365293971914 no 1905 0.448165337641789 2666 6462679
SGTC_3299 9121982 43.1275 µM -0.13072693764407 0.441189586599139 no 1906 0.447995661024246 2668 17594604 YPL160W CDC60
SGTC_170 4197-0004 226 µM -0.130777870403451 0.441168724380757 no 1907 0.447975514743552 2766 218692
SGTC_850 0388-0143 75.9 µM -0.130838473784887 0.441143901257863 no 1908 0.447951543455848 2661 67273
SGTC_2040 5100729 123 µM -0.1310303232707 0.441065321303581 no 1909 0.44787565984779 2637 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_459 nigericin 15.3 µM -0.1334708161257 0.440065919245167 no 1910 0.446910521550793 2758 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_311 1315-0136 58 µM -0.13359944008227 0.440013257203019 no 1911 0.446859663484818 2781 6759207
SGTC_2864 9034755 47.6 µM -0.133831772513783 0.439918136864747 no 1912 0.446767801179607 2623 4930451
SGTC_1004 4084-0029 199 µM -0.134374744435146 0.43969584965106 no 1913 0.446553125757855 2759 716894 YLR208W SEC13
SGTC_2283 7944793 200 µM -0.134444020485084 0.439667490102782 no 1914 0.4465257371331 2694 2970533
SGTC_1475 4092-1048 11.7 µM -0.134887112601254 0.43948610873712 no 1915 0.446350564539513 2687 2881759
SGTC_2726 cimetidine 79.27 µM -0.136519969521362 0.438817802780813 no 1916 0.445705119473582 2646 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_615 k087-0205 167 µM -0.136579757000196 0.438793335883221 no 1917 0.445681489055378 2659 9642773
SGTC_3255 9139072 49.47 µM -0.136636314536194 0.438770190994061 no 1918 0.445659135418198 2714 17646060
SGTC_515 4092-1064 102 µM -0.136877694765768 0.438671413962998 no 1919 0.445563734936133 2766 717353
SGTC_2118 5526350 200 µM -0.138148054878426 0.438151623377036 no 1920 0.445061703771862 2794 743594
SGTC_349 k015-0014 24 µM -0.138913608016857 0.43783843506241 no 1921 0.444759208793604 2639 2196908
SGTC_255 tunicamycin 200.472 nM -0.140188618440629 0.437316913939844 no 1922 0.444255482135033 2765 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1133 3473-0247 50 µM -0.142400725999374 0.43641234818809 no 1923 0.443381744482958 2744 711311
SGTC_3322 9139058 2.11 µM -0.143384943032495 0.436009992860916 no 1924 0.442993086909903 2811 4908926 YPR165W RHO1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.143615532196277 0.435915735834804 no 1925 0.44290203744576 2818 688751
SGTC_1998 st075797 76.8 µM -0.144186631272605 0.43568230559185 no 1926 0.442676548665865 2618 24208315
SGTC_50 0929-0078 56.389 µM -0.144707988040111 0.435469226513036 no 1927 0.442470716002493 2722 1377751
SGTC_590 k048-0076 22.4 µM -0.144763805768778 0.435446414855672 no 1928 0.442448679974197 2765 6832814
SGTC_685 1278-0033 54.9 µM -0.145843920139683 0.435005034784524 no 1929 0.442022301654566 2739 3590572
SGTC_723 4182-0001 115 µM -0.146353085565727 0.43479699646869 no 1930 0.441821330369848 2698 744821 YLR208W SEC13
SGTC_3133 9127736 49.47 µM -0.147109232668176 0.434488078004029 no 1931 0.441522901275672 2636 27243420
SGTC_635 k038-0028 24.7 µM -0.14715142818709 0.4344708405045 no 1932 0.441506248917669 2692 4035102
SGTC_2350 9023895 38.85 µM -0.14782231414726 0.434196790330221 no 1933 0.441241499329917 2800 2997209
SGTC_20 0481-0013 4.944 µM -0.148758822179131 0.433814289116631 no 1934 0.440871972080989 2666 182045
SGTC_1093 fluphenazine 7.97 µM -0.149788588821394 0.433393769513166 no 1935 0.440465706291768 2685 6602611 An atypical antipsychotic.
SGTC_839 0122-0028 230 µM -0.150057500146669 0.43328396821011 no 1936 0.440359625108204 2663 759448
SGTC_96 0929-0093 37.281 µM -0.15199576148264 0.432492694279712 no 1937 0.439595139328922 2661 6991579
SGTC_1203 3992-3522 103 µM -0.15366312433693 0.431812228117253 no 1938 0.438937680948403 3018 5322312
SGTC_1512 0259-0544 12.2 µM -0.15554483559871 0.431044527426705 no 1939 0.438195905167889 2697 18476
SGTC_2944 9067346 25.62 µM -0.155553339797531 0.431041058472133 no 1940 0.438192553280027 2830 6473075
SGTC_2892 9047358 58.44 µM -0.15613539390431 0.430803644970327 no 1941 0.437963150085525 2733 6466771
SGTC_771 0250-0039 27.3 µM -0.156491199318522 0.430658528143919 no 1942 0.437822927854235 2668 3005115
SGTC_854 0422-0053 192 µM -0.157382381585305 0.430295096615349 no 1943 0.437471748937719 2693 3596728
SGTC_344 k064-0035 6.43 µM -0.15758274899607 0.430213393239968 no 1944 0.437392799010327 2697 5088750
SGTC_3206 9114350 49.47 µM -0.158140522567137 0.429985966892504 no 1945 0.43717303497599 2778 17087243
SGTC_1412 3909-8563 178 µM -0.158238805241166 0.429945895563685 no 1946 0.437134313389419 2759 23767530
SGTC_1844 rapamycin 4 nM -0.158365612321698 0.429894195470211 no 1947 0.437084354595097 2673 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2434 5670830 169.91 µM -0.15871356480713 0.429752339095728 no 1948 0.436947275239558 2775 1549830
SGTC_3202 9113761 49.47 µM -0.160486884293321 0.429029517646136 no 1949 0.436248776266584 2882 4798415
SGTC_274 sirtinol 40.1 µM -0.160953833740852 0.428839224201938 no 1950 0.436064880898628 2730 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_564 3555-0129 330 µM -0.161013500259123 0.428814909811477 no 1951 0.436041383854623 2678 563260
SGTC_1123 mangostin 811.285 nM -0.161105982143935 0.428777223536712 no 1952 0.436004964362405 2782 5281650 An antioxidant.
SGTC_538 2922-0838 53.3 µM -0.161825444588049 0.42848406551786 no 1953 0.435721657625898 2695 777039
SGTC_2790 5423970 71.43 µM -0.161893136241046 0.428456485354781 no 1954 0.435695004001801 2836 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_253 dyclonine 31.25 µM -0.162630997978359 0.428155875011429 no 1955 0.435404489523374 2672 3180 An oral anasthetic.
SGTC_3304 9125678 46.087 µM -0.163423383746095 0.427833097600531 no 1956 0.435092546403669 2727 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3174 9107204 49.47 µM -0.163672276266344 0.427731721480778 no 1957 0.434994571763085 2808 3938802
SGTC_1740 st038286 13.222 µM -0.164417679434777 0.427428140757375 no 1958 0.434701173394718 2890 716786
SGTC_551 k048-0028 34.9 µM -0.165132721823255 0.427136965457787 no 1959 0.434419759129194 2839 6836383
SGTC_484 loperamide 105 µM -0.166396600550163 0.426622393474671 no 1960 0.433922424515364 2675 3955 An opioid-receptor agonist.
SGTC_1034 k072-0165 12.7 µM -0.166822939710297 0.426448843085014 no 1961 0.433754684168111 2872 5835461
SGTC_2524 avocatin b 10.57 µM -0.167228031663532 0.426283955014565 no 1962 0.433595314447453 2810 6710748
SGTC_2274 7947094 46.08 µM -0.16763264282329 0.42611927550757 no 1963 0.433436144655272 2682 2971028
SGTC_938 3126-1755 342 µM -0.167731454402546 0.426079060475672 no 1964 0.433397274854144 2735 1777771
SGTC_2349 9023730 187.07 µM -0.169203410063131 0.425480084844116 no 1965 0.432818323811969 2824 4126287
SGTC_2335 9018011 154.17 µM -0.169515486626651 0.425353115117738 no 1966 0.432695596035267 2815 6458208
SGTC_1507 4075-3230 155 µM -0.169847916490811 0.425217873076655 no 1967 0.432564871225431 2663 659771
SGTC_2135 5326629 150.42 µM -0.169953470464752 0.425174932520501 no 1968 0.432523364695319 2751 5020077
SGTC_821 1114-0266 29.2 µM -0.170190481572737 0.425078516943387 no 1969 0.432430168561781 2777 3123235
SGTC_1830 st055982 50.3 µM -0.170765031241038 0.424844810060472 no 1970 0.432204263084626 2691 455313 An antimicrobial agent.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.170914807093764 0.424783890773982 no 1971 0.432145376800981 2947 6710655
SGTC_359 0081-0058 15.9 µM -0.171495174310819 0.424547851298898 no 1972 0.431917212288485 3096 3494159
SGTC_3222 9128301 49.47 µM -0.171602905179034 0.42450403936324 no 1973 0.431874861667428 2747 4911358
SGTC_970 1315-0089 19.5 µM -0.171676953032213 0.424473926160169 no 1974 0.431845752799058 2714 6811083 YLR033W RSC58
SGTC_508 roscovitine 141 µM -0.172232646652507 0.424247955094808 no 1975 0.431627316523392 2710 160355 A CDKinase inhibitor.
SGTC_2279 7948423 32.93 µM -0.172962493959374 0.423951202818922 no 1976 0.431340454361508 2737 1247112
SGTC_1702 st027038 51 µM -0.173623259516643 0.423682576021342 no 1977 0.431080775599428 2769 5521182
SGTC_1777 st045864 34.765 µM -0.173697891418134 0.42365223748871 no 1978 0.431051447369863 2715 4691462
SGTC_333 3486-0131 40.1 µM -0.173840475402723 0.423594277087524 no 1979 0.430995416947873 2857 6744690
SGTC_2038 4100038 30.985 µM -0.174246568356945 0.423429209331977 no 1980 0.430835844510639 2815 3596803
SGTC_2324 6149169 200 µM -0.17744755360032 0.42212855269462 no 1981 0.42957842877714 2798 2888231
SGTC_2357 9067248 200 µM -0.178116620733221 0.421856797363212 no 1982 0.429315694644937 2815 9150235
SGTC_1423 4048-0112 5.59 µM -0.179320068414536 0.421368086149641 no 1983 0.428843194965165 2807 X1423
SGTC_511 blebbistatin 171 µM -0.180819440356429 0.420759371800061 no 1984 0.428254651717511 2859 3476986 A myosin inhibitor.
SGTC_2420 aureobasidin a 50 nM -0.181055737084452 0.420663457400781 no 1985 0.428161913505756 3026 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_474 dl-dihydrosphingosine 5 µM -0.181343199796241 0.420546780741857 no 1986 0.428049099782302 2887 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2767 sibutramine 71.45 µM -0.183126576623041 0.419823092094359 no 1987 0.427349351620665 2867 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2539 epi(13)torulosol 80 µM -0.183494217332009 0.419673938280237 no 1988 0.427205127823884 2824 6708597
SGTC_574 1315-0397 40 µM -0.187181177239756 0.418178760387722 no 1989 0.425759291197707 2719 6794277
SGTC_1747 st037496 66.6 µM -0.187240407133498 0.418154750394489 no 1990 0.425736072360388 2751 723305
SGTC_2549 cedrol 20.94 µM -0.18766019929986 0.417984588194539 no 1991 0.425571516120034 2894 6708665 A sedative which affects the nervous system.
SGTC_2083 5306046 65.942 µM -0.187708800863235 0.417964888606037 no 1992 0.425552465408923 2773 539837
SGTC_3177 9107506 49.47 µM -0.189476258311361 0.417248628332934 no 1993 0.424859780587202 2838 8897194
SGTC_2990 9074105 71.4286 µM -0.191793081634152 0.416310154236691 no 1994 0.423952145209517 2765 6502001
SGTC_37 0566-0070 1.56 µM -0.192596505917821 0.415984822785053 no 1995 0.423637490785779 2858 1626686
SGTC_2715 st079500 56.4 µM -0.192636419107875 0.415968662193516 no 1996 0.423621860385356 2722 28246688
SGTC_2203 7227154 166.4 µM -0.192932085013812 0.41584895341423 no 1997 0.423506078433124 2750 896304
SGTC_1666 st014829 29 µM -0.193483421578521 0.415625749935561 no 1998 0.423290194204683 2707 3858230
SGTC_809 3998-0021 90 µM -0.193773127507175 0.415508476090384 no 1999 0.423176764661592 2866 715485
SGTC_634 1611-4317 11.2 µM -0.194908679621254 0.415048873779774 no 2000 0.422732219577002 2727 2843522
SGTC_3319 9138450 16.7555 µM -0.195688903674123 0.414733153949174 no 2001 0.42242683504014 2773 2029690
SGTC_2211 7117706 200 µM -0.19587085027376 0.414659536663278 no 2002 0.422355626709083 2819 822771
SGTC_1087 pterostilbene 9.05 µM -0.196095839056425 0.414568508254881 no 2003 0.422267576494218 2879 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3026 9090633 49.47 µM -0.196517401039993 0.414397960478278 no 2004 0.422102607072055 2737 25236842
SGTC_1010 4112-3296 15.2 µM -0.196822309775857 0.414274616177794 no 2005 0.421983295961951 2920 704384
SGTC_879 0831-1030 162 µM -0.197373237179617 0.414051771738762 no 2006 0.421767735651053 2783 1549252
SGTC_180 1486-1293 102.781 µM -0.198589837987404 0.413559767406092 no 2007 0.421291801698822 2818 4140536
SGTC_107 0358-0022 2.6945 µM -0.198664321409195 0.413529650038944 no 2008 0.421262667529685 2818 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1754 st042065 16.137 µM -0.198956315646036 0.413411587094654 no 2009 0.421148458226572 2808 1126236 YIL048W NEO1
SGTC_744 1594-0068 283 µM -0.199167199600327 0.413326324593042 no 2010 0.421065978157607 2804 668392
SGTC_420 mitomycin C 81.9 mM -0.199835565349992 0.413056124628653 no 2011 0.420804592586472 2765 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1441 4106-0040 13 µM -0.200179575799145 0.412917067701407 no 2012 0.420670070018003 2750 2904180
SGTC_106 0092-0003 11.579 µM -0.200214603445893 0.412902909334446 no 2013 0.42065637325283 2845 1072148
SGTC_2062 5245942 200 µM -0.200764734082785 0.412680558387699 no 2014 0.420441269781857 2727 1376160
SGTC_3010 9080089 71.4286 µM -0.200979769632093 0.412593653265008 no 2015 0.420357196401411 2873 17027233
SGTC_840 0245-0196 390 µM -0.201876424787316 0.412231322544116 no 2016 0.42000666645523 2892 3827528
SGTC_1562 morin hydrate 59.1 µM -0.202456304146614 0.411997038035636 no 2017 0.419780007629941 2942 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2383 9036125 200 µM -0.202666906376248 0.411911957683072 no 2018 0.419697695618032 2759 79580
SGTC_825 1988-2224 89.6 µM -0.203288843994717 0.411660727775912 no 2019 0.419454637340871 2760 1180859
SGTC_2385 9074692 200 µM -0.203468481706033 0.411588170376057 no 2020 0.419384439178545 2802 17046906
SGTC_2695 st077686 51.995 µM -0.203634456007873 0.411521134445801 no 2021 0.419319582633366 2820 2876092
SGTC_1859 st055998 20 µM -0.205094217434636 0.410931657857506 no 2022 0.418749257113287 2838 676301
SGTC_2778 tioconazole 65.09 nM -0.205538076777503 0.410752459681623 no 2023 0.418575876055968 2737 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_873 0591-4978 488 µM -0.205919291871198 0.410598567572295 no 2024 0.418426977821653 2987 3305145
SGTC_86 0417-1630 471.922 µM -0.206077432470745 0.410534732084881 no 2025 0.418365213349736 2773 3634867
SGTC_3340 9146634 11.102 µM -0.206158449861796 0.410502029290721 no 2026 0.41833357142417 2849 4907387
SGTC_3005 9076496 71.4286 µM -0.206271259694609 0.410456494465156 no 2027 0.418289513611812 2842 21368410
SGTC_2026 5148700 152 µM -0.207705107977878 0.409877837950661 no 2028 0.417729614535527 2763 79838
SGTC_944 3370-0224 231 µM -0.209429019054423 0.409182381000617 no 2029 0.41705667054101 2813 4580514
SGTC_749 1000-0129 128 µM -0.210388884731932 0.408795277508377 no 2030 0.416682083610031 2938 708470
SGTC_2234 tolnaftate 200 µM -0.211759297379447 0.408242759085341 no 2031 0.416147412167513 2810 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_472 calcifediol 10 µM -0.211796116544784 0.408227916967409 no 2032 0.416133049172977 2847 5283731 A vitamin D metabolite.
SGTC_806 3966-4455 5.86 µM -0.212119448822827 0.408097584639984 no 2033 0.416006923485319 2775 714982
SGTC_1807 st050092 58.9 µM -0.212609032778544 0.407900257117192 no 2034 0.415815962692773 2790 5008496
SGTC_1042 0350-0096 82 µM -0.213234985392318 0.40764800004086 no 2035 0.415571840660723 2747 3122515
SGTC_1338 1486-1223 76 µM -0.213479233759389 0.40754957904042 no 2036 0.415476592429715 2859 3444526
SGTC_2057 5236571 38.335 µM -0.214231106735966 0.407246645028608 no 2037 0.415183419739161 2926 54684039 YBR257W POP4
SGTC_1805 st050013 60.3 µM -0.21465226138536 0.407076983587595 no 2038 0.415019222407512 2844 4037144
SGTC_2170 morpholine 200 µM -0.215956417156936 0.40655171735187 no 2039 0.414510859990749 2909 121171 Reacts with secondary amines.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.217057072180809 0.406108544528585 no 2040 0.414081933912953 2803 756377
SGTC_1140 3229-1848 2.98 µM -0.217302881368957 0.406009587191588 no 2041 0.413986155869207 2894 2849525
SGTC_418 lividomycin a 100 µM -0.218910016027281 0.405362738608795 no 2042 0.413360072017909 2863 72394 An antibiotic.
SGTC_1957 st077035 62.4 µM -0.219680769563556 0.40505261296461 no 2043 0.413059891246834 2843 705593
SGTC_1606 st000094 49.2 µM -0.220161937683864 0.404859037094717 no 2044 0.412872519332536 2824 1242210
SGTC_3228 9131799 49.47 µM -0.222891524067533 0.403761355459516 no 2045 0.411809966638211 2860 17015818
SGTC_1217 1183-1422 255 µM -0.225144732383198 0.402855815834431 no 2046 0.410933341378955 2937 2849664
SGTC_2186 6124449 200 µM -0.225884567904294 0.402558597426548 no 2047 0.410645600338908 2968 3834182 YLR033W RSC58
SGTC_2894 9048625 32.47 µM -0.226730081396869 0.402218993356569 no 2048 0.410316817304856 2963 4092861
SGTC_296 1222-0039 74.9 µM -0.228821844833622 0.401379145350675 no 2049 0.409503693736903 2845 5984176
SGTC_3119 9125183 49.47 µM -0.229739644376505 0.401010790160099 no 2050 0.409147043487677 2871 22695334
SGTC_2810 7959871 45.46 µM -0.230955706410079 0.400522864070865 no 2051 0.408674606462338 2925 2974535
SGTC_230 MPP+ 141.667 µM -0.231433406023902 0.400331236898965 no 2052 0.408489057627428 2848 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_62 0180-0423 3.232 µM -0.232149411790262 0.400044059166853 no 2053 0.408210983968584 2842 30102 YGL099W LSG1
SGTC_268 camptothecin 39.6153 µM -0.233062617133845 0.399677866480872 no 2054 0.407856391405377 2820 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2753 fluvastatin 17.09 µM -0.233303754336417 0.399581185875021 no 2055 0.407762771751176 2894 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.235287120314123 0.3987862169886 no 2056 0.40699294552815 2919 5379071
SGTC_2409 alverine citrate 63.97 µM -0.236008830985913 0.398497046299451 no 2057 0.406712908793688 3087 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2444 5485484 36.41 µM -0.236296460339432 0.398381816221114 no 2058 0.4066013167101 2953 6790631
SGTC_3060 1327-0027 12.5 µM -0.236484248013297 0.398306589498759 no 2059 0.406528464476248 2913 16000455 YPR107C YTH1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.236555600579494 0.398278007038883 no 2060 0.406500784094036 2810 688803
SGTC_342 k048-0088 23.3 µM -0.236921845083737 0.398131305157719 no 2061 0.406358711236848 2780 6820570
SGTC_1951 sophoraflavanone G 9.2 µM -0.237078319488027 0.398068632593912 no 2062 0.406298015747054 2804 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3111 9122088 49.47 µM -0.23715333398734 0.398038588030996 no 2063 0.406268918867751 2873 16876704
SGTC_977 1348-1378 135 µM -0.237549226969997 0.397880036282052 no 2064 0.406115367128406 2811 X977
SGTC_2786 7743617 45.45 µM -0.237706518941047 0.397817046874537 no 2065 0.40605436359853 2856 583674
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.240055636611722 0.396876633071856 no 2066 0.405143562771083 2913 279621
SGTC_1088 bifonazole 369 nM -0.240597347128025 0.396659856904051 no 2067 0.40493360324065 2809 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2465 5809242 33.21 µM -0.2407196004998 0.396610939215947 no 2068 0.404886223301016 2816 2731748
SGTC_3348 9149464 3.537 µM -0.242568191180573 0.395871454624943 no 2069 0.404169962548534 2792 1951442
SGTC_141 0443-0274 32.331 µM -0.243271300571401 0.395590290684717 no 2070 0.403897617742866 2962 1627241
SGTC_1121 fusaric acid 630.51 nM -0.244063237725657 0.395273670787685 no 2071 0.403590921871006 2843 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2953 9074162 66.49 µM -0.245680239777461 0.39462740124891 no 2072 0.402964884912419 2956 16451992
SGTC_831 k061-1017 217 µM -0.245821964595866 0.394570771678444 no 2073 0.402910026697683 2899 1240153
SGTC_3277 9138724 49.47 µM -0.247355743205515 0.393958056189791 no 2074 0.402316460947001 2913 15943418
SGTC_1848 st056003 16.4 µM -0.247473358393074 0.393911081964121 no 2075 0.402270953651248 2847 146492
SGTC_2977 9011197 71.43 µM -0.247749713163448 0.393800714952113 no 2076 0.402164032552489 3059 2704722
SGTC_2198 6589944 200 µM -0.247977638304837 0.393709695560327 no 2077 0.402075854286817 2873 5290268
SGTC_64 000l-0018 272.079 µM -0.248648876803731 0.393441677617718 no 2078 0.401816198664356 2797 6811119
SGTC_1248 0469-0687 58.6 µM -0.249014729010787 0.393295618216974 no 2079 0.401674694057409 2952 4017482
SGTC_997 3996-0078 137 µM -0.250275032738465 0.392792581475407 no 2080 0.401187331583384 2915 735687
SGTC_2885 9057732 51.95 µM -0.251702163255083 0.392223173758138 no 2081 0.400635642394185 3013 6471414
SGTC_3016 9080866 49.47 µM -0.251929316368933 0.392132563679332 no 2082 0.400547849533687 2880 17066299
SGTC_712 r015-0009 80.6 µM -0.25236387121308 0.391959238536813 no 2083 0.400379911566653 2955 6813872 YLR060W FRS1
SGTC_200 k038-0079 37.545 µM -0.252596004202298 0.391866659504496 no 2084 0.400290209048472 2868 3436683
SGTC_521 r062-0005 13.8 µM -0.252670594410248 0.391836912816409 no 2085 0.400261386474099 2823 2832033
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.254782489700739 0.390994948782998 no 2086 0.399445550127607 2787 4000243
SGTC_2705 st078069 42.8 µM -0.257383842245769 0.389958551646929 no 2087 0.398441237425789 2943 1530061
SGTC_971 1315-0384 26.7 µM -0.257469420005036 0.389924470108945 no 2088 0.398408209525781 2885 6769120
SGTC_2028 5153890 36.43 µM -0.257922543906379 0.389744026589492 no 2089 0.398233342916564 2870 2830968 YPR165W RHO1
SGTC_3127 9126946 49.47 µM -0.259415641082664 0.389149612067093 no 2090 0.397657281423511 2943 27243249
SGTC_3063 1327-0034 4 µM -0.259762174530756 0.389011691219864 no 2091 0.397523614961591 2942 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3046 9092212 49.47 µM -0.260174517837048 0.388847596169332 no 2092 0.397364579698234 2859 25236637
SGTC_1343 1487-0095 224 µM -0.261486311767225 0.388325690141872 no 2093 0.396858752027764 2969 4560101 YGL055W OLE1
SGTC_322 k048-0136 19.3 µM -0.262943837767281 0.387746040070182 no 2094 0.39629693357017 2963 6823282
SGTC_90 0870-0863 4.608 µM -0.263659656607967 0.387461454341168 no 2095 0.396021092556854 2834 1738164
SGTC_29 0299-0004 12.984 µM -0.264109359225685 0.387282698471457 no 2096 0.395847826128697 2890 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2930 9013230 14.89 µM -0.265173598069025 0.386859760971127 no 2097 0.395437866376982 3016 2995857
SGTC_486 niguldipine 82 µM -0.267180757238438 0.386062464882716 no 2098 0.394664995634909 2861 1236 A calcium channel blocker.
SGTC_3308 9128332 17.569 µM -0.267647970039009 0.385876944630705 no 2099 0.394485151408561 3034 17332805 YDL196W YDL196W
SGTC_1855 st056195 39.6 µM -0.267890096986511 0.385780811441313 no 2100 0.394391958325585 3059 4028379
SGTC_329 k048-0121 21.3 µM -0.268165488849725 0.385671479399306 no 2101 0.394285969141127 2956 6832902
SGTC_2624 nerol 100 µM -0.268653938996189 0.385477584426046 no 2102 0.394098000154915 2852 637566 A natural product oil.
SGTC_782 0083-0095 30.5 µM -0.269765337546345 0.385036510818231 no 2103 0.393670395544694 2834 3591729 An indicator and reagent.
SGTC_213 1246-0773 967 nM -0.270245423144915 0.384846028287495 no 2104 0.393485724810614 2915 6251622
SGTC_580 1123-0028 41 µM -0.270358629631956 0.38480111564055 no 2105 0.393442182054971 2868 1677248 YPR107C YTH1
SGTC_3008 9078912 71.4286 µM -0.270701472937785 0.384665108128881 no 2106 0.393310321928028 2915 16648731
SGTC_2966 9084041 48.03 µM -0.270815598507591 0.384619837139899 no 2107 0.393266431085245 2813 17741380
SGTC_1246 0422-0085 105 µM -0.270819007025132 0.38461848508357 no 2108 0.393265120245551 3026 264295
SGTC_128 0906-2981 13.371 µM -0.271201706091652 0.384466688809597 no 2109 0.39311795043297 3053 6740226
SGTC_828 2074-0507 139 µM -0.273386532308386 0.383600424863037 no 2110 0.392278052136678 3029 X828
SGTC_510 ag-490 170 µM -0.274002713610855 0.383356219450346 no 2111 0.392041268139496 2960 5328779
SGTC_1476 4112-3294 3.34 µM -0.276785135146804 0.382254066515995 no 2112 0.390972547930197 3022 704369
SGTC_702 1488-0190 94 µM -0.277066842754598 0.382142531510181 no 2113 0.39086439057673 2985 949357
SGTC_2939 9044578 71.43 µM -0.277277790480335 0.382059018493738 no 2114 0.390783405931148 2869 2653634
SGTC_2612 dictamnine 15.46 µM -0.278459548049958 0.381591268907845 no 2115 0.390329806730802 2983 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_930 2810-3379 265 µM -0.279434192426167 0.381205626503933 no 2116 0.389955816971983 3103 1015764
SGTC_2658 polymyxin b sulfate 77.05 µM -0.279569346542125 0.381152158703066 no 2117 0.389903963775911 2912 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1304 1165-0502 251 µM -0.279941560538712 0.381004920283581 no 2118 0.389761170372662 2918 767425
SGTC_264 promethazine 12.5 mM -0.280473126955787 0.380794675960773 no 2119 0.389557269995005 2939 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2430 5571206 200 µM -0.283195794842112 0.379718363614624 no 2120 0.388513375849693 3071 1731771
SGTC_1741 st038134 10.228 µM -0.283617076814515 0.379551907377452 no 2121 0.388351924439175 3143 1272587
SGTC_3260 9137109 49.47 µM -0.28618410340713 0.378538111503768 no 2122 0.387368559224718 2996 17478346
SGTC_2261 9010538 184.68 µM -0.28636668282398 0.378466037150109 no 2123 0.387298644945827 3027 6457250
SGTC_781 4335-2806 94.4 µM -0.288154039070846 0.377760690855245 no 2124 0.386614414385597 3072 845254
SGTC_2193 5925765 200 µM -0.28953786242404 0.377214870842975 no 2125 0.386084904997455 3030 877370
SGTC_1497 4476-2978 41.3 µM -0.289719242973424 0.377143347254255 no 2126 0.386015516825283 2998 1528379
SGTC_2903 5923464 63.88 µM -0.291278243341412 0.376528762424653 no 2127 0.385419262844061 3002 2876576
SGTC_1439 4092-1168 46 µM -0.292862727731775 0.375904451897191 no 2128 0.384813539645012 2983 2886240
SGTC_3038 9091290 49.47 µM -0.293055520706333 0.375828510708364 no 2129 0.384739857103619 3083 25236843
SGTC_3087 9117406 49.47 µM -0.293086552112326 0.37581628788099 no 2130 0.384727997761295 3043 42546093
SGTC_2873 9040596 71.43 µM -0.294604336443676 0.375218606638959 no 2131 0.384148074561754 3034 6463863
SGTC_3130 9127414 49.47 µM -0.295168325511157 0.374996592236346 no 2132 0.383932648586548 2933 1494646
SGTC_1854 st056233 32.9 µM -0.295655220762943 0.374804959134435 no 2133 0.383746698848595 3023 5393174
SGTC_3114 9122766 49.47 µM -0.29719493042421 0.374199161083774 no 2134 0.383158846028878 2990 17176985
SGTC_813 k007-0158 173 µM -0.298433267854405 0.373712163002012 no 2135 0.382686250564948 2990 6523916
SGTC_2022 5136654 200 µM -0.301936961818194 0.372335367680222 no 2136 0.381350059229566 3079 1713771
SGTC_401 neomycin 50 µM -0.302045856981423 0.372292602772067 no 2137 0.381308552827798 2991 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2178 5812956 200 µM -0.302272944651293 0.372203426804142 no 2138 0.381222000647985 2894 5403383
SGTC_868 0527-0199 213 µM -0.302381549945964 0.372160780577557 no 2139 0.381180608932808 2965 2849450
SGTC_1706 st031321 9.9705 µM -0.303764061534947 0.371618044574078 no 2140 0.38065382422148 3055 6103185
SGTC_1256 0570-0116 285 µM -0.303963224682391 0.371539879599608 no 2141 0.380577954381991 2972 410638
SGTC_1775 st081588 35.1725 µM -0.303999607776093 0.371525601005952 no 2142 0.38056409498724 2947 1426443 YGL099W LSG1
SGTC_1359 1582-0056 520 nM -0.304245150435732 0.371429242084796 no 2143 0.380470564546543 3048 3661189
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.304846380277138 0.371193333980336 no 2144 0.380241577672211 3043 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1636 st007707 68.9 µM -0.304852955515068 0.371190754282727 no 2145 0.380239073631851 3151 403051
SGTC_542 3381-0244 89.3 µM -0.306150191174315 0.370681916350882 no 2146 0.379745147161326 3119 1112843
SGTC_1410 3909-8106 77.9 µM -0.306450332347012 0.370564218790576 no 2147 0.379630895396371 3030 1039210
SGTC_426 0988-0037 14.6 µM -0.306892586027464 0.37039081521381 no 2148 0.379462566223853 3151 5383008
SGTC_533 1222-0222 6.71 µM -0.307572579745072 0.370124247349874 no 2149 0.379203793780434 3121 3982874
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.307842565616024 0.370018426079974 no 2150 0.379101065328615 3006 1377
SGTC_763 3453-1109 128 µM -0.308438116496298 0.369785034035834 no 2151 0.378874491001769 3099 1560353
SGTC_598 3937-0236 20.2 µM -0.30927365110386 0.36945767497726 no 2152 0.378556686242215 3019 1379313
SGTC_2919 7978188 46.38 µM -0.310405422627377 0.369014402420856 no 2153 0.378126335501069 3122 2980291
SGTC_1729 st035615 45.989 µM -0.310988901754589 0.368785943476713 no 2154 0.377904529358199 3055 17385451
SGTC_2515 chrysin 20.77 µM -0.313478406845937 0.367811709382394 no 2155 0.376958611705378 3028 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1401 3807-4679 7.6 µM -0.313555858433025 0.367781413352005 no 2156 0.376929194843924 2961 3291456
SGTC_1687 st020778 55.3625 µM -0.314920401499419 0.367247792566369 no 2157 0.376411045506241 2991 4259299
SGTC_1223 0764-0573 147 µM -0.319066238900889 0.365628089712123 no 2158 0.374838142068069 2959 1609797
SGTC_2639 lactacystin 53 µM -0.319371857003999 0.365508784659322 no 2159 0.374722274561163 3113 3870 A proteasome inhibitor.
SGTC_2147 5545932 89.7195 µM -0.319527704188667 0.365447951136057 no 2160 0.374663193328225 2997 797404
SGTC_310 1273-0058 1.06 µM -0.320772670642882 0.364962111496796 no 2161 0.374191335748721 3082 2734232
SGTC_3196 9111891 49.47 µM -0.321777109163582 0.364570294151183 no 2162 0.373810778497104 2948 18891510
SGTC_2679 rapamycin 1 nM -0.321985470598242 0.364489032984975 no 2163 0.373731850822552 3048 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_579 4491-1009 110 µM -0.322290221898156 0.364370190643201 no 2164 0.373616420035828 3096 1271041
SGTC_1395 3486-0190 4.35 µM -0.32281760626758 0.364164560003953 no 2165 0.373416689212015 3137 6748079
SGTC_2682 pyrogallin 40.03 µM -0.323023047520401 0.364084467684975 no 2166 0.373338893772207 3012 822798 An ATP competetive kinase inhibitor.
SGTC_2911 7942208 15.64 µM -0.324920416179792 0.363345049838301 no 2167 0.372620652332028 3060 1243384
SGTC_1813 st051246 8.6015 µM -0.324991819866848 0.363317233240965 no 2168 0.372593631375443 3077 5291959
SGTC_2012 4023501 200 µM -0.329883630580278 0.361413263304197 no 2169 0.370743946348916 3069 3477460
SGTC_2865 9030313 51.95 µM -0.331090610561002 0.360944012931622 no 2170 0.370288021870051 2961 42562754
SGTC_2665 lovastatin 100 µM -0.331103552578588 0.360938982459102 no 2171 0.370283134139852 3012 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_171 k064-0041 9.68 µM -0.332491418317851 0.360399668434428 no 2172 0.36975910933723 3005 53325
SGTC_3343 9148379 18.9835 µM -0.332545309446078 0.360378732346391 no 2173 0.36973876621048 3145 1955036
SGTC_352 k048-0007 5.11 µM -0.332595014266164 0.360359422962381 no 2174 0.369720003678106 3080 6811911
SGTC_3203 9113543 49.47 µM -0.332656456307557 0.360335554381782 no 2175 0.369696811018302 3134 17018012
SGTC_3220 9131269 49.47 µM -0.332989295279089 0.360206264855955 no 2176 0.369571181815497 3006 17722206
SGTC_2987 9018338 71.43 µM -0.335123141656119 0.359377763948351 no 2177 0.368766098346131 3105 5055682
SGTC_2183 6420625 130.508 µM -0.335184319076027 0.359354020534522 no 2178 0.368743025057299 3008 2897619
SGTC_676 falcarinol 140 µM -0.335455504626884 0.359248777936188 no 2179 0.368640752127864 3191 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1547 harmine 94.2 µM -0.336278247645935 0.358929550438588 no 2180 0.368330525817236 3026 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1625 st003711 30.1 µM -0.336707811643732 0.358762917056948 no 2181 0.36816858702856 3203 24207034 YER133W GLC7
SGTC_3285 9112818 20.8695 µM -0.336949721111954 0.358669089101272 no 2182 0.368077401316973 2977 17017947 YPR165W RHO1
SGTC_2809 7964133 12.99 µM -0.337379493455834 0.358502416953061 no 2183 0.367915420630402 3035 1253665
SGTC_733 4069-0007 56.1 µM -0.340268781348042 0.357382608867469 no 2184 0.3668270624235 3027 5717425 YNL287W SEC21
SGTC_1743 st037606 46.3785 µM -0.34170986161366 0.356824543975666 no 2185 0.366284624947357 3009 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_409 arachidonic acid 100 µM -0.342860746726233 0.356379078381267 no 2186 0.365851611669741 3029 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.342969529866789 0.356336982524371 no 2187 0.365810691526785 3011 4620898
SGTC_3169 9102970 49.47 µM -0.344873096095997 0.355600642448836 no 2188 0.36509488868564 3041 17027839
SGTC_2673 kobusone 100 µM -0.345952882855201 0.355183197072749 no 2189 0.364689062394869 3027 6710676 An epoxy ketone and protein crosslinker.
SGTC_75 0159-0059 199.013 µM -0.346136090813739 0.355112386133292 no 2190 0.364620220674268 3302 5377270
SGTC_2683 piperine 63.03 µM -0.346767137297844 0.354868521314684 no 2191 0.36438313380311 3034 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3121 9125696 49.47 µM -0.346855096449387 0.354834534650721 no 2192 0.364350091289921 3044 1235365
SGTC_2236 dapsone 200 µM -0.347474365437043 0.354595287122291 no 2193 0.364117486808212 3058 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2171 5739187 198.077 µM -0.34752816943563 0.354574503266085 no 2194 0.364097279775683 2940 2262761
SGTC_89 0302-0250 142.109 µM -0.349031185361582 0.353994080954799 no 2195 0.363532948750704 3015 4203518 YLR208W SEC13
SGTC_1469 k284-2957 126 µM -0.349051587574979 0.353986204525965 no 2196 0.363525290451547 3046 23884841
SGTC_2190 6049624 200 µM -0.350300390268129 0.353504213874087 no 2197 0.363056636202867 3106 2265554
SGTC_2091 4-phenylthiadiazole 200 µM -0.3536507282883 0.352212271840562 no 2198 0.361800326140949 3023 270010
SGTC_2002 4023503 131 µM -0.353750159807285 0.352173955472512 no 2199 0.361763063970305 3177 4736863 YCR052W RSC6
SGTC_1325 1431-0015 227 µM -0.354023866078157 0.352068489323154 no 2200 0.36166049874072 3028 1103340
SGTC_2358 9037157 4 µM -0.354402287596833 0.351922692405605 no 2201 0.361518710212063 3117 2388925
SGTC_1455 4262-0120 131 µM -0.356083488313878 0.351275228733687 no 2202 0.360889021154069 3190 1529587
SGTC_1966 st070145 16.1 µM -0.35626837073861 0.351204053147958 no 2203 0.360819796927228 2957 3748532
SGTC_1155 4088-0394 48.2 µM -0.356649021661971 0.351057527518182 no 2204 0.360677286837263 3000 2326248
SGTC_2184 6075246 200 µM -0.356774727492664 0.351009143883746 no 2205 0.360630228677156 3085 2267320
SGTC_2956 9076196 2.52 µM -0.357491609716111 0.350733265180702 no 2206 0.360361903132504 3164 16423868
SGTC_939 1165-0479 45.3 µM -0.35778839576241 0.35061907565038 no 2207 0.36025083767062 3166 1377347
SGTC_1674 st016616 23.6 µM -0.358101220298415 0.350498729861038 no 2208 0.360133782933275 2992 625830
SGTC_2288 7946289 167.31 µM -0.358321629852205 0.350413945771934 no 2209 0.360051316513591 3229 1246052
SGTC_2360 9040895 200 µM -0.358652853275156 0.350286549356736 no 2210 0.359927401240181 3083 4914414
SGTC_814 3342-0569 96 µM -0.358987719280225 0.350157769039151 no 2211 0.359802138189606 3064 4346283
SGTC_622 1348-1566 26.3 µM -0.359110677177802 0.350110487114425 no 2212 0.359756147208998 3107 7340407
SGTC_196 k015-0023 18.111 µM -0.359487290212902 0.349965679732767 no 2213 0.359615292093839 3040 5211998
SGTC_2955 9076254 12.21 µM -0.362078719210963 0.348969870086711 no 2214 0.358646602935495 3142 16459619
SGTC_704 1310-0270 142 µM -0.363953598017125 0.348250056994835 no 2215 0.357946329925332 3100 5718033
SGTC_3020 9089140 49.47 µM -0.364798016078816 0.347926041940837 no 2216 0.357631093068613 3140 17217859
SGTC_207 4185-0010 4.486 µM -0.365938773103019 0.347488493787565 no 2217 0.357205381620358 3134 3761753
SGTC_54 0159-0055 9 µM -0.367092728950187 0.347046089752937 no 2218 0.356774925364396 3282 3319099
SGTC_928 2764-0428 58.7 µM -0.367336155548966 0.346952791366959 no 2219 0.356684144030008 3160 662578
SGTC_505 gw-5074 63.9 µM -0.367368745779984 0.346940301176597 no 2220 0.356671990737314 3152 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1832 st054113 55 µM -0.369229174084397 0.34622756902137 no 2221 0.3559784560255 3189 1251267
SGTC_280 3448-3607 3.04 µM -0.369419799628643 0.346154570861994 no 2222 0.355907421063413 3165 626179
SGTC_2201 6605497 169.863 µM -0.369938912396471 0.345955810765393 no 2223 0.355714003540662 3080 670741
SGTC_1522 st012842 45.6 µM -0.370060980655052 0.34590907891403 no 2224 0.355668527215207 2959 3491067 YOR116C RPO31
SGTC_2014 4013930 200 µM -0.370975825265114 0.345558920260284 no 2225 0.355327768816144 3143 64556
SGTC_2109 5483026 200 µM -0.371029650517948 0.345538322646281 no 2226 0.355307723757103 3099 759335
SGTC_856 0433-0016 11.3 µM -0.371255540460104 0.345451885051835 no 2227 0.355223604463701 3138 3911780
SGTC_616 4092-0450 108 µM -0.373345677685331 0.344652469348432 no 2228 0.354445592081835 3108 787165
SGTC_652 0437-0092 114 µM -0.373882572592442 0.344447234678942 no 2229 0.354245841385462 3083 3091274
SGTC_2298 7976326 193.81 µM -0.37423759644011 0.344311547600339 no 2230 0.354113777478033 3030 2235818
SGTC_2400 5203494 178.7 µM -0.380398621786051 0.341960060676438 no 2231 0.351824768762359 3097 6777674
SGTC_3095 9117207 49.47 µM -0.381120784436128 0.341684830689435 no 2232 0.351556812742217 3162 17015229
SGTC_2082 5219693 150 µM -0.381586835899501 0.341507254232712 no 2233 0.35138392505804 3053 2834649
SGTC_3197 9113331 49.47 µM -0.382451745792123 0.341177796407685 no 2234 0.351063157288474 3293 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1245 0418-0076 17.2 µM -0.382728918314694 0.341072242617249 no 2235 0.350960385187956 3235 6790114
SGTC_445 e6 berbamine 66 µM -0.384288478582383 0.340478557594057 no 2236 0.350382323204759 3163 6610268 A calcium/calmodulin antagonist.
SGTC_2605 digitonin 300 nM -0.386367416234637 0.339687773271751 no 2237 0.349612289105949 3255 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1999 st074831 12.5 µM -0.387092570931638 0.339412105309844 no 2238 0.349343838640297 3093 17112523
SGTC_2111 5486399 200 µM -0.387129682687367 0.339397999564903 no 2239 0.349330101986224 3095 689674
SGTC_2130 NSC 7 2.4545 µM -0.387726891276982 0.339171038512653 no 2240 0.349109076600136 3188 21448
SGTC_177 1327-0068 8.361 µM -0.389209216528693 0.338607953117708 no 2241 0.34856069306462 3193 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1337 1486-1011 40.3 µM -0.38925532355624 0.338590444388145 no 2242 0.34854364092023 3169 X1337
SGTC_1209 2323-2347 50.3 µM -0.391591589287243 0.337703725861548 no 2243 0.347680001686056 3186 5412760
SGTC_1067 clotrimazole 1.36 µM -0.392538233779471 0.337344687430515 no 2244 0.347330283514399 3105 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1162 k048-0130 20.1 µM -0.392892766005069 0.337210260370961 no 2245 0.347199342365575 3086 6797406
SGTC_2733 amorolfine 100 µM -0.39301721367704 0.337163078798338 no 2246 0.347153383812219 3155 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_980 1473-0395 201 µM -0.393595505760509 0.33694386580311 no 2247 0.346939849916018 3067 768876
SGTC_954 1189-0853 2.85 µM -0.3945652235818 0.336576399478609 no 2248 0.346581891476089 3132 2828194
SGTC_3082 9117008 49.47 µM -0.394927959873064 0.336438983718156 no 2249 0.346448027373409 3127 41448529
SGTC_1235 benzylparaben 21.5 µM -0.395414337808434 0.336254762950635 no 2250 0.346268564687832 3166 7180
SGTC_1289 0976-0073 69.1 µM -0.395708202000571 0.336143477839959 no 2251 0.346160152031963 3198 3391136
SGTC_464 bw-b 70c 158 µM -0.395840999325482 0.336093192771881 no 2252 0.346111164452188 3212 5353454
SGTC_602 3130-1533 38.1 µM -0.395966228606334 0.336045776108307 no 2253 0.346064971005825 3209 720941
SGTC_2774 tamoxifen 10.92 µM -0.398572407501013 0.335059568785065 no 2254 0.345104148037903 3153 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_93 0109-0045 59.227 µM -0.398683433684168 0.33501758041544 no 2255 0.345063238001794 3184 88733
SGTC_1461 k072-0203 53.8 µM -0.400004736957258 0.334518042547786 no 2256 0.344576513911415 3144 5418714
SGTC_1299 1079-1439 3.74 µM -0.400471425045771 0.334341674277808 no 2257 0.344404662996315 3120 323161
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.401633434287983 0.333902692869677 no 2258 0.343976910056708 3179 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_136 0097-0015 404.482 µM -0.404129702020109 0.332960426998567 no 2259 0.343058672201558 3215 4861337
SGTC_2830 7992007 71.43 µM -0.404975768475559 0.3326413012017 no 2260 0.342747661322297 2975 1952075
SGTC_958 1222-0007 33 µM -0.406066337527789 0.332230130922627 no 2261 0.342346929404953 3276 7312461
SGTC_2315 7733312 200 µM -0.407070593815992 0.331851681102743 no 2262 0.341978070201824 3097 726316
SGTC_19 0279-0214 38.434 µM -0.407650185826211 0.331633342284906 no 2263 0.341765257033477 3139 3566274 YBR002C RER2
SGTC_3001 9076041 71.4286 µM -0.40773015579035 0.331603221189685 no 2264 0.341735897804429 3101 16004211
SGTC_1815 st051655 58.2 µM -0.407820629290187 0.331569145196923 no 2265 0.341702683585359 3215 5984156
SGTC_1693 xanthone 101.9 µM -0.408316221301611 0.331382509864443 no 2266 0.341520765852245 3136 7020 An insecticide.
SGTC_2432 5630864 12.22 µM -0.408679936295196 0.331245564823015 no 2267 0.341387279839581 3239 5714970
SGTC_157 1348-1695 65.819 µM -0.412056913589588 0.329975153407495 no 2268 0.340148854150591 3193 5380510
SGTC_860 0443-0016 25.1 µM -0.412087398266274 0.329963694037139 no 2269 0.340137682449534 3171 5337942
SGTC_300 r073-0011 5.04 µM -0.412317189815734 0.329877319168964 no 2270 0.340053475395855 3241 2735780
SGTC_25 0118-0223 35.662 µM -0.414393749138705 0.329097186436413 no 2271 0.339292883015774 3268 5333628
SGTC_1953 st076800 12.1 µM -0.415007986457914 0.328866568903933 no 2272 0.339068028315792 3141 297591
SGTC_611 3453-1652 23.7 µM -0.416503254018557 0.32830543794418 no 2273 0.338520893376361 3238 1560575
SGTC_1391 3442-0225 151 µM -0.417295210526256 0.328008396150779 no 2274 0.338231245653432 3101 5227075
SGTC_1367 1812-0510 76.9 µM -0.417767773227057 0.327831202262113 no 2275 0.338058457616372 3183 1142582 YDR527W RBA50
SGTC_2417 cerulenin 830 nM -0.419293992094568 0.327259190362458 no 2276 0.337500643398501 3262 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1241 0364-0022 50.8 µM -0.419324156515822 0.327247889113891 no 2277 0.337489622266261 3160 4563895
SGTC_1836 st055642 81 µM -0.42096556065088 0.326633167992472 no 2278 0.336890115142236 3153 8571
SGTC_3338 9144300 39.5675 µM -0.421309303950901 0.32650449244271 no 2279 0.336764618594233 3182 4901274
SGTC_815 1582-0027 36.9 µM -0.421357807880811 0.326486337328854 no 2280 0.336746911855123 3242 3128206
SGTC_2603 homopterocarpin 100 µM -0.422115947292575 0.326202617736359 no 2281 0.33647019418654 3233 101795 A weak amylase inhibitor.
SGTC_281 1672-3440 14.9 µM -0.422228257292825 0.326160596352678 no 2282 0.336429209039588 3245 6833000
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.422354991584454 0.326113180694196 no 2283 0.3363829623881 3254 6708760
SGTC_1527 coumarin 137 µM -0.422906772256005 0.325906773333477 no 2284 0.336181640782272 3301 323 A hepatotoxic, DNA x-linker.
SGTC_1432 4049-0298 68.4 µM -0.423566370124011 0.325660104250955 no 2285 0.335941042849208 3238 741646
SGTC_2185 6113692 200 µM -0.42391391462009 0.325530164114267 no 2286 0.335814297961041 3260 874150
SGTC_2339 9000433 200 µM -0.424261015793481 0.325400410887131 no 2287 0.335687733382903 3172 2988954
SGTC_3122 9126309 49.47 µM -0.424814349054168 0.325193607818777 no 2288 0.335486008299773 3238 17591206
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.425898344650125 0.324788630791871 no 2289 0.335090960592698 3102 688667
SGTC_2215 7188065 200 µM -0.427376107468823 0.324236877192812 no 2290 0.334552703482946 3270 940217
SGTC_624 k048-0052 28 µM -0.42744182957151 0.324212347424598 no 2291 0.334528772893331 3183 6835531
SGTC_1178 0988-0033 191 µM -0.427763310486119 0.32409237059305 no 2292 0.334411725647634 3260 5392207
SGTC_1513 0337-0559 19 µM -0.428239001648579 0.323914875938199 no 2293 0.334238561878416 3150 775073
SGTC_3143 9086658 49.47 µM -0.428309904563481 0.323888423358905 no 2294 0.334212754420709 3207 25236626
SGTC_3227 9130768 49.47 µM -0.428901052809865 0.323667911404061 no 2295 0.333997617008057 3182 17720899
SGTC_131 0141-0277 33.849 µM -0.429596023637876 0.323408750383953 no 2296 0.333744765051074 3292 1547771
SGTC_3172 9105863 49.47 µM -0.4317872192208 0.322592194610144 no 2297 0.332948034717579 3199 2348785
SGTC_2351 9026858 72.31 µM -0.43211686093675 0.322469426495998 no 2298 0.33282824036597 3094 1409300
SGTC_2105 5350118 200 µM -0.432454768882958 0.322343599888887 no 2299 0.332705459712296 3194 2133313
SGTC_1259 0671-0132 43 µM -0.432912107479778 0.322173333366355 no 2300 0.332539311869788 3137 X1259
SGTC_1930 st074634 34.3 µM -0.434887609226135 0.321438285855876 no 2301 0.331822004465788 3130 684253 YOR116C RPO31
SGTC_507 nimesulide 162 µM -0.435489339942937 0.321214531718331 no 2302 0.331603637499033 3347 4495 A COX2 inhibitor.
SGTC_2893 9048488 25.97 µM -0.436191282464766 0.32095359572036 no 2303 0.331348976158876 3197 6467338
SGTC_2585 alliin 100 µM -0.436466369256487 0.32085136067319 no 2304 0.331249197263055 3369 87310 A garlic compound which reacts with lipids.
SGTC_2802 7925815 54.55 µM -0.436795142751393 0.320729190968703 no 2305 0.331129960955368 3145 1262923
SGTC_1275 0867-0008 21.1 µM -0.437541514515856 0.32045191703485 no 2306 0.330859337823936 3120 3422836
SGTC_1159 4092-0538 61.2 µM -0.437990560227827 0.320285146723283 no 2307 0.330696563195046 3197 717301
SGTC_764 1951-2361 146 µM -0.439533282142947 0.319712474580359 no 2308 0.33013758582602 3180 5438930
SGTC_609 0986-0026 86.3 µM -0.440691021495084 0.319282993432675 no 2309 0.329718348731905 3177 2848610
SGTC_1406 3909-7906 11.9 µM -0.441485137923314 0.318988543884344 no 2310 0.3294309092949 3233 X1406
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.442907468347331 0.318461445076217 no 2311 0.328916332624818 3197 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_906 1165-0455 526 µM -0.443613871972616 0.318199796674977 no 2312 0.328660887344267 3193 3252859
SGTC_6 0844-0013 19.835 µM -0.443852382847119 0.318111473902009 no 2313 0.32857465659575 3310 1584900
SGTC_251 melphalan 456.522 µM -0.443914027902552 0.318088647852146 no 2314 0.328552371049029 3243 460612 A DNA alkylator.
SGTC_2308 7584454 197.62 µM -0.445816571985519 0.317384510245981 no 2315 0.32786487503014 3378 893577
SGTC_2088 5278280 127.392 µM -0.446216775534379 0.317236477621272 no 2316 0.327720333146947 3282 791502
SGTC_2739 tacrine 100.86 µM -0.449503518053747 0.31602184123369 no 2317 0.32653423540532 3280 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1648 st011736 69.8 µM -0.449715306749174 0.315943641269346 no 2318 0.326457866454448 3329 2855514
SGTC_146 3448-8650 53.125 µM -0.450876225057419 0.315515135066908 no 2319 0.326039379842193 3204 2891488 YIL048W NEO1
SGTC_1097 itavastatin 7.23 µM -0.451197153480311 0.315396720997621 no 2320 0.325923730519462 3218 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1714 st033236 13.627 µM -0.453032506405681 0.314719889005284 no 2321 0.325262667273643 3368 2916566
SGTC_710 3448-4187 58 µM -0.45371792631373 0.314467282776402 no 2322 0.325015931366508 3270 3946412
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.455918724486452 0.313656783063522 no 2323 0.3242242121285 3255 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3003 9075612 71.4286 µM -0.457513944740331 0.313069864224864 no 2324 0.323650840786216 3256 6501993
SGTC_2219 9098279 200 µM -0.457887593328022 0.312932458535588 no 2325 0.323516600387107 3294 902349
SGTC_2522 biochanin a 4.94 µM -0.458242089678413 0.312802119915624 no 2326 0.323389262024767 3328 5280373 A possible chelator.
SGTC_278 4092-0821 23.9 µM -0.458283309080186 0.312786966186403 no 2327 0.323374456977144 3282 877900
SGTC_463 ikarugamyin 104 µM -0.45903202475761 0.312511766560384 no 2328 0.323105584466486 3270 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_541 4513-1321 94 µM -0.461477594454987 0.311613596319749 no 2329 0.322227996317191 3229 747515
SGTC_2725 haloperidol 53.21 µM -0.461968705533002 0.311433363628086 no 2330 0.322051881235322 3192 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.462877232820805 0.311100062626748 no 2331 0.321726183792137 3219 71034 A hepatoprotective.
SGTC_3282 9108498 15.4605 µM -0.464019120969355 0.310681370837416 no 2332 0.321317023185698 3275 16459645
SGTC_1137 ixabepilone 100 µM -0.464557446112259 0.310484070169114 no 2333 0.321124206025255 3297 154225 A novel microtubule stabilizer.
SGTC_313 3474-0040 5.03 µM -0.464566400925042 0.310480788616097 no 2334 0.32112099900029 3181 1043375 YIL048W NEO1
SGTC_1066 ketoconazole 628 nM -0.466357467332154 0.309824743452668 no 2335 0.320479825279398 3343 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_411 enrofloxacin 100 µM -0.468227433192676 0.309140444123633 no 2336 0.319810978042137 3388 71188 A bacterial gyrase inhibitor.
SGTC_1288 0973-0013 65.5 µM -0.470527161875999 0.308299783738886 no 2337 0.318989216545855 3342 4315430
SGTC_1723 st034307 2.5525 µM -0.470632367501565 0.308261350063161 no 2338 0.318951644677708 3262 867466
SGTC_663 1486-0733 13.9 µM -0.472241689562462 0.307673695381574 no 2339 0.318377142874491 3222 722445 YPR165W RHO1
SGTC_73 0327-0325 16.231 µM -0.473433467780699 0.307238827308184 no 2340 0.317951978650052 3303 53298
SGTC_117 lucigenin 22.078 µM -0.473912482290412 0.307064115948453 no 2341 0.317781158832171 3315 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2121 5257820 149.641 µM -0.474015918068638 0.307026395479464 no 2342 0.317744278022421 3350 791256
SGTC_2735 sertaconazole 140 nM -0.474940311228527 0.306689382889807 no 2343 0.317414758969032 3311 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2556 citropten 84.59 µM -0.475306898979845 0.30655577860758 no 2344 0.317284121226863 3245 2775 A potential DNA crosslinker.
SGTC_1392 3455-1037 33.9 µM -0.477664071633746 0.305697312820007 no 2345 0.316444660049249 3368 981132
SGTC_992 3909-8734 162 µM -0.479660904340667 0.304970914628487 no 2346 0.315734265863104 3266 4288319
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.479673957408958 0.304966168769239 no 2347 0.315729624332103 3269 2724278 An inhibitor of dopamine biosynthesis.
SGTC_447 ml7 120 µM -0.479782353856076 0.3049267590515 no 2348 0.315691080841586 3338 4216 Selective myosin light chain kinase inhibitor.
SGTC_2859 9028643 45.46 µM -0.481358325633827 0.304354038462038 no 2349 0.31513092511726 3290 17151580
SGTC_527 4476-4215 268 µM -0.481904860432388 0.304155535301642 no 2350 0.314936766596555 3230 4418754
SGTC_229 benomyl 22.8748 µM -0.482118769080119 0.30407785871676 no 2351 0.314860788673295 3316 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2443 5493264 126.67 µM -0.482233154461166 0.304036325614943 no 2352 0.314820163499444 3363 5340055
SGTC_1174 0739-0097 51.1 µM -0.482421773869881 0.303967843810433 no 2353 0.314753178222467 3265 728447
SGTC_415 dibenzyl ketone 100 µM -0.482804683341459 0.303828842521538 no 2354 0.314617212570809 3305 7593
SGTC_2506 ethyl hematommate 54.16 µM -0.483194134070326 0.30368749576224 no 2355 0.314478949994182 3301 3940691 An allergen.
SGTC_11 0438-0307 1.3 µM -0.485529630460287 0.302840470135215 no 2356 0.313650349761412 3354 4011476
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.485955356197314 0.302686184202231 no 2357 0.313499409535244 3210 279621
SGTC_2486 5283202 22.39 µM -0.486246583408317 0.302580661747923 no 2358 0.31339617348212 3263 1377751
SGTC_1018 4259-0013 28.1 µM -0.486952507197762 0.302324947739626 no 2359 0.313145993852856 3340 6801262
SGTC_756 0508-1999 28.3 µM -0.487651350552756 0.302071894087358 no 2360 0.312898408227124 3240 6753853
SGTC_1370 2001-0092 44.6 µM -0.487923664960194 0.301973313834313 no 2361 0.312801955747635 3447 790957
SGTC_1605 st000082 49.1 µM -0.489186192480548 0.301516456510819 no 2362 0.312354941970149 3348 1114022
SGTC_2090 5301565 104.445 µM -0.490823581805991 0.300924415646075 no 2363 0.311775614807987 3280 2056344
SGTC_3094 9117742 49.47 µM -0.490827893032578 0.300922857501673 no 2364 0.311774090060264 3288 17149698
SGTC_3352 9151559 45.5865 µM -0.491336580649322 0.300739035423924 no 2365 0.311594205612923 3280 17159339
SGTC_1163 k060-0048 49.9 µM -0.493152092305762 0.300083385955497 no 2366 0.310952562833373 3306 6809982
SGTC_540 1187-0821 17.3 µM -0.494305346684507 0.299667238567988 no 2367 0.310545274846383 3264 847520
SGTC_3040 9091894 49.47 µM -0.494365151055285 0.299645665523752 no 2368 0.310524160419491 3259 25236966
SGTC_258 haloperidol 50.781 µM -0.496573668047804 0.298849487367814 no 2369 0.309744862921152 3307 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_674 0498-0004 451 µM -0.498082135876876 0.298306232503618 no 2370 0.309213075616382 3323 4231473
SGTC_324 1315-0088 19.6 µM -0.499111678785902 0.297935714494289 no 2371 0.308850355248609 3341 6787421
SGTC_811 0416-0114 265 µM -0.502508907173871 0.296714590773903 no 2372 0.307654794225141 3379 6612453
SGTC_2995 9067767 71.4286 µM -0.502819949660664 0.296602902077003 no 2373 0.307545433128921 3289 11673567
SGTC_2986 9022445 71.43 µM -0.504139201299174 0.296129401265565 no 2374 0.307081780565747 3389 6459286
SGTC_1094 duloxetine 25.4 µM -0.504181321968621 0.29611428918943 no 2375 0.307066982281231 3281 60834 A selective serotonin reuptake inhibitor.
SGTC_299 1273-0059 1.44 µM -0.505975161392572 0.295471023264873 no 2376 0.306437043348099 3351 2848077
SGTC_2575 plumbagin 510 nM -0.507808928112686 0.294814104633752 no 2377 0.305793673958562 3252 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2540 epiandrosterone 100 µM -0.509714678896638 0.294132113169789 no 2378 0.305125683833549 3418 441302 A steroid.
SGTC_1466 k213-0079 57.5 µM -0.509804548079574 0.29409997061635 no 2379 0.3050941995299 3355 3657981
SGTC_2586 curcumin 80 µM -0.509949295052963 0.294048203921387 no 2380 0.305043492658318 3378 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2058 5236698 133 µM -0.513365342886257 0.292827727614755 no 2381 0.303847891906339 3291 766665
SGTC_1286 0929-0070 131 µM -0.513801876372647 0.292671933730012 no 2382 0.303695257969199 3407 1420408
SGTC_2936 9038235 15.59 µM -0.51454121818783 0.292408158823639 no 2383 0.303436825191771 3327 4749415
SGTC_696 1560-0013 611 µM -0.517358308054728 0.29140412026345 no 2384 0.302453028940278 3472 1650269
SGTC_1135 dihydrocapsaicin 536.708 nM -0.517981906552814 0.291182081245561 no 2385 0.302235446674243 3334 107982 A Capsaicinoid.
SGTC_2855 9016525 58.44 µM -0.520984353900471 0.290114134641278 no 2386 0.301188835418055 3371 43811474
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.52332843989781 0.289281640025719 no 2387 0.300372856525905 3308 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_658 3253-0951 102 µM -0.529074254569752 0.287245795531056 no 2388 0.298376970151135 3375 1184878
SGTC_3041 9091929 49.47 µM -0.529224595606994 0.287192618176828 no 2389 0.298324828284719 3490 25236887
SGTC_2505 galangin 7.89 µM -0.530580523433155 0.286713221575882 no 2390 0.297854747627095 3324 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2085 5307070 144.047 µM -0.532893524839779 0.285896322481699 no 2391 0.297053643891847 3309 2840351
SGTC_2851 9015922 71.43 µM -0.533714197491449 0.285606745899513 no 2392 0.296769642467501 3440 2996893
SGTC_803 4488-1585 147 µM -0.534833672388737 0.285211961341621 no 2393 0.29638243829813 3411 747204
SGTC_2640 pentamidine 10.38 µM -0.535468582470708 0.284988174939214 no 2394 0.29616293846421 3407 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2471 5466956 24.79 µM -0.538592498036436 0.283888311481644 no 2395 0.295084032554752 3316 724419
SGTC_1429 4049-0205 9.46 µM -0.538657142363294 0.283865573077602 no 2396 0.295061725489227 3445 22774478
SGTC_2008 4012253 172 µM -0.539682213391981 0.283505124682671 no 2397 0.294708104159553 3353 603940
SGTC_751 0833-0568 350 µM -0.540866726602504 0.283088884593346 no 2398 0.294299723246087 3406 6954252
SGTC_2713 st079149 53.4 µM -0.541581223661832 0.282837950921416 no 2399 0.294053514770745 3406 3103253
SGTC_1840 st055363 71 µM -0.541611684507169 0.282827255349129 no 2400 0.294043020387272 3374 676033
SGTC_788 1182-0090 188 µM -0.541997089346793 0.28269194675551 no 2401 0.293910255502672 3506 5715185
SGTC_21 0849-0113 22.993 µM -0.542481659465406 0.282521867200468 no 2402 0.293743369354103 3375 1560156
SGTC_1470 k295-0292 231 µM -0.543483120102226 0.282170519927783 no 2403 0.293398604931889 3447 5045612
SGTC_1403 3909-7815 62.9 µM -0.543529142163069 0.282154378842089 no 2404 0.293382765811173 3352 6615483
SGTC_957 1187-1561 14.1 µM -0.544867005358909 0.281685351193754 no 2405 0.29292249518569 3420 1538454
SGTC_3179 9107801 49.47 µM -0.544991559184306 0.281641704288301 no 2406 0.292879661473523 3379 4818259
SGTC_3093 9117344 49.47 µM -0.545663869625227 0.281406165520568 no 2407 0.292648506008013 3452 24824913
SGTC_1935 st074532 41.6 µM -0.545876841537872 0.28133157228742 no 2408 0.292575299149182 3440 2829742
SGTC_3074 9116018 49.47 µM -0.547287690174064 0.280837664924346 no 2409 0.292090549779454 3373 17027303
SGTC_522 1273-0010 11.6 µM -0.547827914870443 0.280648655088721 no 2410 0.291905034575232 3503 5705015
SGTC_565 1418-0001 44.5 µM -0.550410817556713 0.279745819617869 no 2411 0.291018815351226 3492 2862145
SGTC_2588 indole-3-carbinol 100 µM -0.551808770140013 0.279257763586414 no 2412 0.290539688967198 3464 3712 Induces cell cycle arrest.
SGTC_2240 6690706 185.951 µM -0.55233882600804 0.279072817665059 no 2413 0.290358117173736 3326 805876
SGTC_2979 9012552 45.46 µM -0.55266008492118 0.278960753711702 no 2414 0.290248095099484 3491 17100905
SGTC_3163 9099914 49.47 µM -0.553395696853302 0.27870423449515 no 2415 0.289996242437809 3446 16268368
SGTC_44 0929-0055 61.211 µM -0.555122738409651 0.278102440177128 no 2416 0.289405355388555 3331 1379590
SGTC_765 1319-0117 244 µM -0.555837772939301 0.277853469299637 no 2417 0.289160880370124 3443 3487746 YGL099W LSG1
SGTC_3339 9145883 14.936 µM -0.556839978840374 0.277504690257884 no 2418 0.288818383090108 3434 2030670
SGTC_1871 st057448 67.3 µM -0.558202878002985 0.277030729470578 no 2419 0.288352927919239 3554 691747
SGTC_1818 st052136 56.3 µM -0.558514463536017 0.276922428393848 no 2420 0.288246565411248 3434 674169
SGTC_2860 9025725 38.96 µM -0.559006172060857 0.276751562247703 no 2421 0.28807875396166 3329 40546248
SGTC_2617 dihydrotanshinone i 20.83 µM -0.55920292728003 0.276683205307691 no 2422 0.288011617792608 3393 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2368 9071271 200 µM -0.559767313586275 0.27648717143953 no 2423 0.287819080740272 3386 27209959
SGTC_2731 amoxapine 43.43 µM -0.560615556932652 0.276192670857472 no 2424 0.287529821941798 3467 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3186 9110464 49.47 µM -0.562136498740277 0.275665002722914 no 2425 0.287011511220384 3497 17018021
SGTC_3189 9110682 49.47 µM -0.562880718086268 0.275406987598222 no 2426 0.286758055459377 3449 17122418
SGTC_668 1682-0499 62.6 µM -0.563319296614602 0.275254991458392 no 2427 0.286608740255769 3424 682214
SGTC_2519 cryptotanshinone 88.04 µM -0.56361234944438 0.275153452508629 no 2428 0.28650899021179 3481 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_277 nystatin 15.5 µM -0.563830196354681 0.275077983373917 no 2429 0.286434849618613 3355 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2044 5102272 200 µM -0.564570264583329 0.2748216762522 no 2430 0.286183047664027 3458 592666
SGTC_2150 5556613 200 µM -0.564803279891482 0.274741000657899 no 2431 0.286103787945102 3410 743190
SGTC_633 0437-0093 97.7 µM -0.566843710521123 0.274035052928779 no 2432 0.285410185193549 3450 2831118
SGTC_1934 st074720 32.6 µM -0.568566144656485 0.273439824089553 no 2433 0.284825302849947 3452 17250992
SGTC_1800 st050079 29.0735 µM -0.569079070668124 0.273262693850101 no 2434 0.284651240513964 3444 3645560
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.569104308379439 0.273253979904802 no 2435 0.284642677363666 3373 23665772 A membrane-active detergent.
SGTC_1237 0330-0133 46.1 µM -0.570229177806846 0.272865730710524 no 2436 0.284261134356754 3425 X1237 YHR072W ERG7
SGTC_681 1642-0006 26.6 µM -0.570778016047302 0.27267639830534 no 2437 0.284075063409955 3490 4446530
SGTC_2037 5169046 200 µM -0.57097491354127 0.272608490586156 no 2438 0.284008324058565 3477 5718022
SGTC_216 k038-0035 28.382 µM -0.574078672259976 0.271539149727067 no 2439 0.28295728253514 3441 4444231 YPR107C YTH1
SGTC_680 0417-1641 114 µM -0.575551960721539 0.271032288478141 no 2440 0.282459029867953 3393 2835990
SGTC_1571 st070080 73.4 µM -0.577783578182973 0.270265436226432 no 2441 0.281705121833235 3535 4315245
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.581188771935545 0.269097401621977 no 2442 0.280556617090426 3602 16725076
SGTC_2825 7998094 58.44 µM -0.581334299569997 0.269047539871798 no 2443 0.280507584020063 3439 2987815
SGTC_72 0744-0168 198.391 µM -0.583524540155528 0.268297664009889 no 2444 0.279770120964107 3357 677577
SGTC_165 k038-0023 64.381 µM -0.584180919231672 0.26807314347218 no 2445 0.279549298746623 3434 46368543
SGTC_49 0717-0965 32.132 µM -0.585152295668511 0.267741048815194 no 2446 0.279222658960349 3617 5889349 YGL099W LSG1
SGTC_1682 st012968 530 nM -0.586381423547872 0.267321131289934 no 2447 0.278809612461661 3378 24207270
SGTC_2952 9073731 13.78 µM -0.588152272734086 0.26671672564631 no 2448 0.27821504470481 3446 16457353
SGTC_1136 pergolide 1.05886 µM -0.588648645746264 0.266547433412456 no 2449 0.278048497031498 3445 47811 A dopamine receptor agonist.
SGTC_199 4063-0024 41.6 µM -0.588975212105218 0.266436084824939 no 2450 0.277938950994349 3512 306215
SGTC_2534 helenine 20.12 µM -0.589809060172669 0.266151876342556 no 2451 0.277659333908897 3487 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_648 0375-0473 33.3 µM -0.59012997829695 0.266042535643335 no 2452 0.277551755983408 3494 1713139
SGTC_2068 5226020 147 µM -0.590264578089293 0.265996682634077 no 2453 0.27750664160862 3479 1810509
SGTC_143 4032-1194 15.74 µM -0.590809130501486 0.265811215292328 no 2454 0.277324158289673 3513 1806963
SGTC_2246 7293507 91.5585 µM -0.591102603458173 0.265711289476196 no 2455 0.277225837790687 3508 887656
SGTC_215 1287-0124 461.5 µM -0.593722257689645 0.26482015721084 no 2456 0.276348946829904 3465 5560863
SGTC_346 4513-0042 7.16 µM -0.595007938925307 0.264383361300825 no 2457 0.275919082138272 3502 2827372
SGTC_2533 agelasine 13.65 µM -0.596924067461573 0.263733059192951 no 2458 0.275279038939803 3574 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3307 9126885 69.2785 µM -0.597383779174141 0.263577162124753 no 2459 0.275125590496207 3454 24824909
SGTC_3117 9124945 49.47 µM -0.597842104999537 0.263421781860733 no 2460 0.274972646596245 3408 17592065
SGTC_148 3253-0744 288.01 µM -0.599751679590534 0.262774907188219 no 2461 0.274335870383654 3517 6893655
SGTC_497 capsazepine 133 µM -0.599769739171117 0.262768793326515 no 2462 0.274329851623181 3445 2733484 A calcium channel blocker.
SGTC_606 k015-0008 38.6 µM -0.601197420121593 0.262285698823691 no 2463 0.273854251301265 3565 1970475
SGTC_845 0330-0138 4.51 µM -0.602230232968861 0.261936502448929 no 2464 0.273510446880079 3501 9039800
SGTC_2711 st079103 59.1 µM -0.602532548738156 0.26183433391847 no 2465 0.273409851950041 3477 54693780
SGTC_1075 aripiprazole 15.2 µM -0.604487457881588 0.261174160236194 no 2466 0.272759802653464 3525 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1076 itraconazole 331 nM -0.605316270683894 0.260894528220893 no 2467 0.272484436237044 3546 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2793 7325131 81.82 µM -0.605927140440291 0.260688526328735 no 2468 0.272281568058036 3463 4176441
SGTC_3135 9127742 49.47 µM -0.606753814706773 0.260409882642337 no 2469 0.272007151344004 3473 3643468
SGTC_3098 9119039 49.47 µM -0.606888880479163 0.260364371163195 no 2470 0.271962328978043 3537 17161528
SGTC_384 k007-0144 5.16 µM -0.607253097856919 0.260241665664988 no 2471 0.271841479625285 3515 6824886
SGTC_1829 berberine 14.4 µM -0.607299732927041 0.2602259563773 no 2472 0.271826007779363 3562 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2286 7945697 125 µM -0.608073445089224 0.259965398379231 no 2473 0.271569381752493 3489 1245733
SGTC_166 k072-0058 166.424 µM -0.608802671439972 0.259719944804399 no 2474 0.271327621342078 3553 5846229
SGTC_2680 butyl paraben 22.24 µM -0.609505172467122 0.259483599990774 no 2475 0.271094822657154 3552 7184 An antifungal and steroid mimetic.
SGTC_337 1315-0038 354 µM -0.613064221441957 0.258287926179621 no 2476 0.269916938180414 3520 1626437
SGTC_1764 st044502 93.5 µM -0.613378665173765 0.258182425259022 no 2477 0.269812994798947 3547 8407
SGTC_414 piperonyl butoxide 100 µM -0.614070247312754 0.257950466973675 no 2478 0.269584454049701 3469 5794 A potent inhibitor of cytochrome P450.
SGTC_2543 pimpinellin 60.67 µM -0.614271256008958 0.257883068464957 no 2479 0.269518046763562 3460 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.614393994675001 0.257841918505037 no 2480 0.269477501595727 3606 5393153
SGTC_1845 st056753 3.01 µM -0.615077051500874 0.257612975826318 no 2481 0.269251918264714 3480 5375839
SGTC_2908 7930301 100 µM -0.615262073852146 0.257550979376022 no 2482 0.269190829906835 3457 2223178
SGTC_3188 9110789 49.47 µM -0.615410466700481 0.257501262173732 no 2483 0.269141840443489 3576 849217
SGTC_2866 9034245 58.44 µM -0.615857805955241 0.257351416819609 no 2484 0.268994185803594 3525 6462273
SGTC_1073 triclabendazole 3.09 µM -0.615922022478147 0.257329909913145 no 2485 0.2689729929969 3551 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1306 1185-0270 9.02 µM -0.616845791318769 0.257020631718864 no 2486 0.268668222582873 3553 1548076
SGTC_3333 9141820 12.094 µM -0.619340118553218 0.256186496841606 no 2487 0.267846160283282 3504 1939433
SGTC_2824 7998404 51.95 µM -0.620770304697642 0.255708861818995 no 2488 0.267375382084619 3515 837851
SGTC_2269 7935389 174.42 µM -0.622941640232272 0.254984597152254 no 2489 0.266661436582374 3535 97605
SGTC_3280 9140961 49.47 µM -0.624062770973328 0.254611056496334 no 2490 0.266293181086398 3509 4901226
SGTC_1398 3558-0053 112 µM -0.624684944719151 0.254403883097038 no 2491 0.266088928072894 3469 4532369
SGTC_2440 5628896 157.78 µM -0.624877189024711 0.254339886845956 no 2492 0.266025832363957 3557 5522048
SGTC_1339 1486-1321 22.7 µM -0.62496241436291 0.254311518863463 no 2493 0.265997863332641 3520 3469382
SGTC_2313 7726885 200 µM -0.626852608558015 0.253682778156106 no 2494 0.265377927410504 3530 726423
SGTC_1309 pyrazolanthrone 13.4 µM -0.627062061522806 0.253613157492374 no 2495 0.265309277287902 3573 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1771 st048882 4.1505 µM -0.62978979172377 0.252707396744094 no 2496 0.264416062727955 3462 4580403
SGTC_1465 k213-0056 144 µM -0.629982502965509 0.252643470198591 no 2497 0.264353016004207 3491 24048857 YMR208W ERG12
SGTC_15 0266-0086 27.098 µM -0.630594484475204 0.252440518996207 no 2498 0.264152853064405 3627 1712902 YIL048W NEO1
SGTC_1984 st072354 53.1 µM -0.632858718316678 0.251690379621245 no 2499 0.263412953976034 3495 5762938
SGTC_3036 9090181 49.47 µM -0.634007146674447 0.251310356427052 no 2500 0.263038079051734 3585 25236586
SGTC_848 0368-0089 85.6 µM -0.634326403088762 0.251204766099356 no 2501 0.262933914455766 3560 762535
SGTC_2155 5570423 76 µM -0.634426220983514 0.251171757312532 no 2502 0.262901350947362 3505 797402
SGTC_661 1304-0007 33.6 µM -0.635567105860653 0.250794641022164 no 2503 0.262529307552076 3557 3117130
SGTC_1433 4060-0023 7.6 µM -0.636473670420145 0.250495192542061 no 2504 0.262233868451729 3585 3840627
SGTC_1407 3909-7909 12.3 µM -0.636537116085268 0.250474242820553 no 2505 0.262213198608667 3592 4411780
SGTC_3298 9116858 71.43 µM -0.636947473996672 0.250338765304815 no 2506 0.262079529043758 3594 2506942
SGTC_2606 farnesol 9.78 µM -0.637165819330871 0.250266695573115 no 2507 0.262008419696726 3597 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3182 9108849 49.47 µM -0.637935504741064 0.250012731560934 no 2508 0.261757832261614 3601 17133045
SGTC_120 rhodamine 6G 52.259 µM -0.638014641936414 0.249986627349468 no 2509 0.261732074439156 3586 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1002 4049-0206 172 µM -0.639235777240765 0.249584006823092 no 2510 0.261334780410384 3595 4662749
SGTC_3161 9100388 49.47 µM -0.640239218980959 0.249253420063974 no 2511 0.261008544582352 3606 25236368
SGTC_529 4076-0302 30.3 µM -0.641078226371267 0.248977185505619 no 2512 0.26073592995815 3548 5816522
SGTC_3044 9093193 49.47 µM -0.641431291120537 0.248860991286263 no 2513 0.260621254148971 3556 25236277
SGTC_1332 1480-0653 17.5 µM -0.642090532823303 0.248644110992992 no 2514 0.260407201253118 3568 5749438
SGTC_2447 5741742 33.78 µM -0.642613659301942 0.248472082163026 no 2515 0.260237408835138 3603 1776504
SGTC_546 peri-Naphthalide 147 µM -0.644110873859118 0.247980077650311 no 2516 0.259751769806774 3519 223824 A penicillin ester.
SGTC_2870 9038528 12.99 µM -0.644269649603791 0.247927932345157 no 2517 0.25970029648162 3588 6463316
SGTC_3212 9128307 49.47 µM -0.64437460099536 0.24789346730621 no 2518 0.259666275301632 3479 27243542
SGTC_727 3032-0951 202 µM -0.644482864703794 0.247857917213605 no 2519 0.259631182807461 3555 3652836
SGTC_1705 st027868 56.3335 µM -0.648855601581157 0.246424337714501 no 2520 0.258215857285476 3607 292948
SGTC_548 1436-0017 110 µM -0.649202436937916 0.246310820020084 no 2521 0.258103768383831 3641 9677137
SGTC_2592 piperlongumine 83.33 µM -0.649389192009612 0.246249707515366 no 2522 0.258043424058131 3540 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_554 4483-2211 187 µM -0.650976701656971 0.245730549700755 no 2523 0.25753076332789 3556 747107
SGTC_1611 st001856 99.4 µM -0.653427777517312 0.244930138328258 no 2524 0.256740267976442 3552 647478
SGTC_185 k048-0037 25.491 µM -0.654005050733585 0.244741831123456 no 2525 0.256554275811293 3621 6827589
SGTC_2158 5657123 3.6195 µM -0.654051525040275 0.244726674540483 no 2526 0.256539305266626 3584 2858827
SGTC_1781 st038725 66.3 µM -0.656091472608351 0.244061888260739 no 2527 0.255882635392106 3612 4270275 YIL048W NEO1
SGTC_917 harmaline 728.087 nM -0.656106701202951 0.244056929170774 no 2528 0.255877736528089 3576 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3321 9137793 26.8275 µM -0.656826317949941 0.243822652766715 no 2529 0.255646299900331 3605 4904192
SGTC_512 prima-1 270 µM -0.657495777019508 0.243604814581944 no 2530 0.255431092726698 3615 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.658311400204026 0.24333955751544 no 2531 0.255169026996805 3569 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3023 9089636 49.47 µM -0.660973521483069 0.242474869347586 no 2532 0.254314647244987 3692 17249241
SGTC_2080 5212524 12.4 µM -0.661075255130703 0.242441858117309 no 2533 0.254282026679072 3595 260183
SGTC_2319 6033012 152.6 µM -0.661673711634046 0.242247716150922 no 2534 0.254090177948287 3567 847246
SGTC_1917 st066507 28.5 µM -0.662109988127415 0.242106239227418 no 2535 0.253950367543491 3576 3156428
SGTC_2560 caryophyllene 100 µM -0.662586768568865 0.241951678820907 no 2536 0.253797623306527 3654 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3331 9141060 1.957 µM -0.662610464701155 0.24194399851833 no 2537 0.25379003313004 3598 4906567 YPR165W RHO1
SGTC_2536 dehydroabietamide 32.04 µM -0.66273515839831 0.241903585438413 no 2538 0.253750094095849 3631 3983547
SGTC_1821 st053465 65.6 µM -0.663160650278575 0.241765711595936 no 2539 0.253613835112303 3583 675086
SGTC_2010 4012422 159 µM -0.664792817190639 0.241237229785493 no 2540 0.253091508723649 3593 952393
SGTC_926 2268-1401 59.4 µM -0.664833726045672 0.241223991915243 no 2541 0.253078424336905 3613 2931578
SGTC_947 3447-0010 211 µM -0.665674583578192 0.240951982731474 no 2542 0.25280956128526 3641 748350
SGTC_1979 st071809 45.3 µM -0.666016293126279 0.240841490727879 no 2543 0.252700343109754 3678 4976333
SGTC_1778 st046819 58.9 µM -0.670582476830978 0.239367660921041 no 2544 0.251243274329961 3662 671715
SGTC_1431 4049-0260 9.09 µM -0.671414460287272 0.239099652687068 no 2545 0.250978267782018 3615 3854841
SGTC_3171 9103192 49.47 µM -0.671722271165738 0.239000538631496 no 2546 0.250880260185307 3662 13018434
SGTC_2212 7123476 200 µM -0.673198524311952 0.238525502489957 no 2547 0.250410499952056 3588 1085715
SGTC_3097 9117246 49.47 µM -0.673913038934683 0.238295768144833 no 2548 0.250183300966344 3654 16423892
SGTC_890 0929-0006 47.2 µM -0.674428668092337 0.238130055776808 no 2549 0.250019410861422 3624 1378169
SGTC_3090 9117696 49.47 µM -0.675493783992387 0.23778794996201 no 2550 0.249681049645403 3605 7923821
SGTC_1317 1273-0028 910 nM -0.676117711054186 0.237587675375513 no 2551 0.249482956326514 3622 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3142 9086498 49.47 µM -0.676656151334311 0.237414915661212 no 2552 0.249312071737615 3586 25236367
SGTC_1919 st067113 52.3 µM -0.676659205503116 0.237413935921377 no 2553 0.249311102614732 3641 1268243
SGTC_1157 4092-0394 27.6 µM -0.677248791913883 0.237224845423375 no 2554 0.249124057584144 3723 3659885
SGTC_575 k072-0246 11.9 µM -0.677422263797876 0.237169225762659 no 2555 0.249069038214872 3656 6796779
SGTC_724 3910-0327 137 µM -0.678152442801386 0.236935189679541 no 2556 0.248837521211155 3643 2885483
SGTC_2472 5377652 49.4 µM -0.678517067200229 0.236818368255606 no 2557 0.248721953081481 3642 1610903
SGTC_2880 9042983 58.44 µM -0.679252781871798 0.236582750273273 no 2558 0.24848885450169 3646 6464714
SGTC_1949 st076024 69.1 µM -0.680260478224601 0.23626023760672 no 2559 0.248169772198914 3624 2921930
SGTC_1801 st050089 28.441 µM -0.680595145771608 0.236153181021594 no 2560 0.24806384965569 3665 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_124 0136-0217 7.121 µM -0.680630000377617 0.236142032940825 no 2561 0.248052819532249 3746 3976905
SGTC_2834 9001755 58.44 µM -0.681853449479398 0.23575090227132 no 2562 0.247665811452394 3584 2989575
SGTC_1503 4585-0012 61.3 µM -0.68250148629931 0.235543872892763 no 2563 0.247460951635707 3656 2922052
SGTC_351 caspofungin 25 nM -0.682578536864307 0.235519264097072 no 2564 0.247436600148412 3691 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_646 4092-0839 27.3 µM -0.682898115164024 0.235417210722917 no 2565 0.247335612525193 3690 877796
SGTC_1958 st076513 41.9 µM -0.682899585183508 0.235416741346787 no 2566 0.247335148045898 3620 732122 YGL099W LSG1
SGTC_790 1575-0012 79.1 µM -0.683392884660251 0.235259260360882 no 2567 0.247179307472428 3687 378741 YLR208W SEC13
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.683415097394207 0.23525217053371 no 2568 0.2471722913782 3625 5355888
SGTC_708 3448-5400 146 µM -0.684461991574597 0.234918158250339 no 2569 0.24684174115382 3634 3462195
SGTC_2757 clomiphene 4.22 µM -0.686292106368816 0.234334888923704 no 2570 0.246264462828691 3699 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1124 fisetin 1.16336 µM -0.686410127013594 0.234297302516872 no 2571 0.246227260100253 3649 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2139 5578692 56.4705 µM -0.686588811042714 0.234240402801841 no 2572 0.246170940661234 3608 650991 YMR113W FOL3
SGTC_1153 4055-0057 267 µM -0.687627626305937 0.233909756509676 no 2573 0.245843653235113 3673 882706
SGTC_1901 st060216 58.6 µM -0.68767989471522 0.233893126743829 no 2574 0.24582719180988 3667 688792
SGTC_460 trequinsin 123 µM -0.688624539918786 0.233592690477071 no 2575 0.245529787025529 3696 5537 A vasodilator.
SGTC_1128 3448-9350 235 µM -0.688685825499905 0.233573206520824 no 2576 0.245510499026639 3664 619386
SGTC_820 1582-0060 59.9 µM -0.689384214881138 0.233351237726864 no 2577 0.245290757137457 3653 3848840
SGTC_1449 4112-4002 201 µM -0.69091861568918 0.232863971095148 no 2578 0.244808343382712 3634 2059539
SGTC_2052 5265182 7.135 µM -0.693386017873899 0.232081605819993 no 2579 0.244033667249866 3658 1239884
SGTC_978 1416-0512 87.4 µM -0.694510059592825 0.231725679752323 no 2580 0.243681197202892 3705 6814003
SGTC_3286 9117135 37.221 µM -0.694583417109031 0.231702461785529 no 2581 0.243658203765359 3639 3438150
SGTC_1707 st032323 6.317 µM -0.694913759262378 0.231597923148586 no 2582 0.243554674678084 3604 3132057 YMR211W DML1
SGTC_2377 9073351 62.6 µM -0.695213430080785 0.231503113373398 no 2583 0.243460778529917 3640 7337946 YHR072W ERG7
SGTC_998 3996-0085 177 µM -0.695632116999286 0.231370685558154 no 2584 0.243329623707556 3702 715391
SGTC_851 0394-0702 453 µM -0.695795864918568 0.231318904703324 no 2585 0.243278339613056 3662 762646
SGTC_969 1313-0238 134 µM -0.696152268202436 0.23120622414285 no 2586 0.243166738120619 3691 5212874
SGTC_1614 st002383 48.6 µM -0.696553019815285 0.231079558987823 no 2587 0.243041282788356 3673 1947235
SGTC_1850 st056238 17 µM -0.696598878220818 0.231065067038035 no 2588 0.243026929042418 3684 5393177
SGTC_3150 9097574 49.47 µM -0.696902689772715 0.230969070805433 no 2589 0.242931847177982 3644 17217476
SGTC_1884 5633444 25 µM -0.697235535645337 0.230863926075501 no 2590 0.242827701743753 3687 5724239
SGTC_3218 9131285 49.47 µM -0.703862776441431 0.228775979102423 no 2591 0.240759117314099 3680 17156417
SGTC_2692 st077426 47.7 µM -0.704043971356537 0.228719041967918 no 2592 0.240702695287732 3658 25238571
SGTC_3284 9108171 64.8615 µM -0.704880203083088 0.22845637480346 no 2593 0.240442395552327 3645 8687505
SGTC_2678 equilin 100 µM -0.705519015418527 0.228255832909524 no 2594 0.240243651278877 3694 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2502 avocadyne acetate 18.59 µM -0.705718773139885 0.228193143428367 no 2595 0.240181521979146 3656 3952079
SGTC_1481 3346-2004 36 µM -0.706706681260192 0.227883252971152 no 2596 0.239874388347178 3697 2770522
SGTC_786 4544-0069 423 µM -0.707034481478405 0.227780479800735 no 2597 0.239772524938305 3723 748821 YLR208W SEC13
SGTC_869 0564-0080 44.1 µM -0.709301166610302 0.227070534312148 no 2598 0.239068802316458 3709 6843321
SGTC_3002 9075603 71.4286 µM -0.709459187484054 0.227021087362106 no 2599 0.23901978476215 3676 20105405
SGTC_18 0111-0177 500 nM -0.711199429230133 0.226476943064037 no 2600 0.238480331117499 3780 721752
SGTC_695 3505-6186 243 µM -0.712270814926144 0.226142305385897 no 2601 0.238148546460886 3696 1819379
SGTC_1664 st014217 9.02 µM -0.713353914126638 0.225804293305279 no 2602 0.237813391649065 3745 3982782
SGTC_742 0kpi-0133 140 µM -0.714366341967342 0.22548859479829 no 2603 0.23750033948574 3710 2728852
SGTC_1374 2889-5571 141 µM -0.714816472409289 0.225348313947943 no 2604 0.237361227615013 3716 2853281
SGTC_1381 2324-0066 62.1 µM -0.715139218069373 0.225247762339021 no 2605 0.237261511291684 3713 10885928
SGTC_1981 st071826 47 µM -0.71532473944498 0.225189974544015 no 2606 0.237204202549418 3678 11838600
SGTC_728 3030-5151 22.5 µM -0.717641325459814 0.224469091924515 no 2607 0.236489234950389 3730 3125388
SGTC_1862 st057513 3.81 µM -0.720882756013333 0.223462614823288 no 2608 0.235490826607264 3687 5393163
SGTC_2079 5212404 121 µM -0.721002905736619 0.223425357266576 no 2609 0.235453863480458 3689 758462
SGTC_3273 9137859 49.47 µM -0.722850533948699 0.222852866403387 no 2610 0.234885858406163 3774 2377234
SGTC_2565 isoliquiritigenin 100 µM -0.724162099200137 0.222446983321397 no 2611 0.234483111923412 3724 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3211 9128781 49.47 µM -0.724385822850881 0.222377790875763 no 2612 0.234414450558394 3736 17194361
SGTC_1354 1498-1681 81 µM -0.725686730568802 0.22197569414254 no 2613 0.234015419132104 3776 5754243
SGTC_2712 st079126 47.7 µM -0.725942678501194 0.221896632261274 no 2614 0.233936955753013 3704 3152970
SGTC_891 0929-0073 133 µM -0.726052298989113 0.221862775598322 no 2615 0.233903354962954 3752 5603632
SGTC_1167 k781-0610 148 µM -0.726568636386538 0.221703342708656 no 2616 0.233745123575926 3740 4525169
SGTC_1826 st055655 41.6 µM -0.727827230353204 0.221314992758829 no 2617 0.233359676654489 3750 676168
SGTC_1597 7-benzyloxygramine 47.5 µM -0.728982536759656 0.220958855784321 no 2618 0.233006172414972 3703 260807
SGTC_468 gf-109203x 121 µM -0.731460296539773 0.220196164022421 no 2619 0.232249023610679 3669 2396 A protein kinase C inhibitor.
SGTC_338 4055-0136 114 µM -0.732090316336196 0.220002475462301 no 2620 0.232056721976363 3684 2900563
SGTC_2777 climbazole 1.536 µM -0.733282338120561 0.219636276790016 no 2621 0.231693122495238 3688 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_208 k072-0098 12.366 µM -0.733456228865292 0.219582885426833 no 2622 0.231640107573753 3730 5948901
SGTC_3000 9075062 71.4286 µM -0.734944494514572 0.219126233789846 no 2623 0.231186649386182 3710 17057871
SGTC_301 4119-0100 24.5 µM -0.737205295365549 0.218433587306483 no 2624 0.230498756847423 3764 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3078 9116413 49.47 µM -0.738301423789105 0.218098218457899 no 2625 0.230165650743503 3672 17177322
SGTC_3011 9081274 71.4286 µM -0.73877105500931 0.217954622074027 no 2626 0.2300230154007 3739 6625322
SGTC_3274 9138298 49.47 µM -0.740929555677317 0.217295331461297 no 2627 0.22936807694776 3713 17015756
SGTC_383 2324-0395 7.37 µM -0.741383450394001 0.217156840947622 no 2628 0.229230488048055 3765 3146421
SGTC_964 1287-0107 19.4 µM -0.741827572991959 0.217021381433158 no 2629 0.229095906174191 3740 51516812 YPR165W RHO1
SGTC_973 1325-0077 65.9 µM -0.742723917656489 0.216748140806277 no 2630 0.228824423093385 3768 2835149
SGTC_1103 duloxetine 36.1 µM -0.743437195797374 0.216530848172659 no 2631 0.22860851592395 3830 60835 A selective serotonin reuptake inhibitor.
SGTC_1772 st048439 82.2 µM -0.744184458988936 0.216303337599049 no 2632 0.228382444352399 3761 2927068 YDL195W SEC31
SGTC_2280 7785178 200 µM -0.744378324504814 0.216244336225223 no 2633 0.2283238142198 3754 2954328
SGTC_1000 4048-0884 8.67 µM -0.744606416399998 0.216174930266883 no 2634 0.228254843944584 3732 13040088
SGTC_2648 atorvastatin 78.68 µM -0.746298900540887 0.215660328330925 no 2635 0.227743437729802 3741 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3303 9125618 40.5795 µM -0.747021388592067 0.215440871417232 no 2636 0.227525325084017 3780 22695467
SGTC_325 2810-4341 181 µM -0.748026554206379 0.215135766329996 no 2637 0.227222070397626 3737 774970
SGTC_940 3232-1287 54.8 µM -0.74877784273997 0.214907886257766 no 2638 0.226995558310504 3698 1585493 YIL048W NEO1
SGTC_789 1309-1135 70.6 µM -0.748923912189092 0.214863596906126 no 2639 0.226951533434601 3756 3092424
SGTC_518 1021-0119 62.6 µM -0.753118507730201 0.213594028050564 no 2640 0.225689351851395 3769 1097762
SGTC_2352 9027995 87.8 µM -0.755111689111501 0.212992291439884 no 2641 0.225090985059783 3732 2997347
SGTC_3346 9158254 43.5805 µM -0.755346926410495 0.212921339187476 no 2642 0.225020424552591 3766 17639500
SGTC_2289 7946404 165.07 µM -0.755619167754049 0.212839242999681 no 2643 0.224938780162227 3795 1246120 YPR165W RHO1
SGTC_1041 0206-0046 107 µM -0.755901708955372 0.212754060362353 no 2644 0.22485406463284 3794 50494
SGTC_556 4058-0063 51.5 µM -0.757258840936006 0.212345179544046 no 2645 0.224447402178025 3829 6615692
SGTC_370 0180-0345 38.7 µM -0.758297325977929 0.212032612004623 no 2646 0.224136503869818 3695 3989527
SGTC_1516 st013856 110 µM -0.759162683768384 0.211772358664195 no 2647 0.22387762276659 3796 5281404 A mutagen and neurotoxin.
SGTC_3072 9116419 49.47 µM -0.75921919438342 0.211755369798098 no 2648 0.223860722920361 3787 17170162
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.759866669893414 0.211560775245634 no 2649 0.223667143146219 3718 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1198 1612-1005 86.7 µM -0.762877909114707 0.210657143597865 no 2650 0.222768105957097 3823 6998509
SGTC_197 4544-0043 41.561 µM -0.763733493600407 0.210400808113313 no 2651 0.222513038384255 3770 896523
SGTC_1708 st033234 31.827 µM -0.764452318161503 0.210185587897705 no 2652 0.222298870589091 3868 674664
SGTC_2845 9003024 42.97 µM -0.765702737227405 0.209811513481087 no 2653 0.22192659900416 3778 2990173
SGTC_2657 nystatin 74.44 µM -0.766024714099432 0.209715254525617 no 2654 0.221830798537244 3808 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3137 9097352 49.47 µM -0.766897246771664 0.209454530694105 no 2655 0.221571305379157 3834 44120435
SGTC_469 w7 172 µM -0.767365415817469 0.209314714495659 no 2656 0.221432142413249 3815 45115570 A P450 inhibitor.
SGTC_1986 st071812 45 µM -0.768736029106729 0.208905704049403 no 2657 0.221025015870239 3729 11838594
SGTC_3166 9102297 49.47 µM -0.769593683126313 0.208650007587117 no 2658 0.220770476646747 3770 25237072
SGTC_1445 4239-0156 97.7 µM -0.770210322978594 0.208466279877693 no 2659 0.220587570701767 3881 4008346
SGTC_2299 7976368 114.88 µM -0.770512185870431 0.208376374688879 no 2660 0.220498064658294 3831 2979718
SGTC_16 erodoxin 22.806 µM -0.77076289016776 0.208301723682765 no 2661 0.220423743587331 3812 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1910 st062352 60.4 µM -0.770936738629043 0.208249966932033 no 2662 0.220372214793461 3735 2245730
SGTC_1757 st041620 31.8375 µM -0.771109317977116 0.208198595516738 no 2663 0.220321068995857 3858 5289815
SGTC_183 3914-0051 30.55 µM -0.772669285967689 0.207734581752664 no 2664 0.219859064113115 3795 1596232
SGTC_1399 3562-5772 25 µM -0.772784915970437 0.207700211848888 no 2665 0.219824840927984 3735 23847490
SGTC_1701 st028638 40.4 µM -0.772795426815343 0.207697087768125 no 2666 0.219821730169087 3751 3490878
SGTC_2685 mycophenolic acid 18.85 µM -0.774860508443804 0.207083833559269 no 2667 0.219211044992018 3784 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_379 3970-0972 5.9 µM -0.776715083615273 0.206534006191716 no 2668 0.218663442859209 3798 2898042 YBL034C STU1
SGTC_912 3474-0017 2.18 µM -0.7781605016638 0.206106082195801 no 2669 0.218237199462327 3830 3360550
SGTC_126 0417-1624 672.48 µM -0.783396083657937 0.204560466139166 no 2670 0.216697277622799 3876 41912 YDL195W SEC31
SGTC_887 0885-0007 9.62 µM -0.784672903329081 0.204184580092353 no 2671 0.21632268689767 3890 5719458
SGTC_2149 5554786 194.827 µM -0.78570765671796 0.203880258508564 no 2672 0.216019388246513 3838 745063 YPR165W RHO1
SGTC_1613 st002381 52.1 µM -0.787213165051752 0.203437970694208 no 2673 0.215578545897945 3782 551167
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.7875394849695 0.203342180055337 no 2674 0.21548306187166 3818 2724 A muscle relaxant with antifungal properties.
SGTC_1684 st024538 14.6195 µM -0.787859368477191 0.20324830494102 no 2675 0.215389485008656 3792 6732859
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.788739264808984 0.202990218249015 no 2676 0.21513220689759 3801 803109
SGTC_1071 trifluoperazine 6.31 µM -0.789919230399526 0.202644424150268 no 2677 0.214787469944693 3910 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1978 st071761 42 µM -0.791796574402251 0.202094986453644 no 2678 0.214239650039201 3842 5147680
SGTC_160 3453-0671 289.699 µM -0.79316776622265 0.201694246991335 no 2679 0.213840042455405 3860 5322268
SGTC_1734 st037168 69.4 µM -0.793838081225946 0.201498516528675 no 2680 0.213644850049128 3881 708907
SGTC_2387 9077560 195.08 µM -0.795751494008379 0.200940430808266 no 2681 0.213088245090907 3812 5303272
SGTC_1774 st048371 48.465 µM -0.796088668059466 0.200842183340599 no 2682 0.212990250101736 3800 4242727
SGTC_2479 5617353 43.85 µM -0.796601928051136 0.200692682419525 no 2683 0.21284112865256 3846 2731746
SGTC_1213 1315-0166 115 µM -0.797385594504591 0.200464547178229 no 2684 0.2126135614894 3900 768401
SGTC_1531 st059297 52.4 µM -0.797878888288729 0.200321023016114 no 2685 0.212470387904512 3842 7566702
SGTC_273 hydroxyurea 18.1 mM -0.798175119687427 0.200234863965834 no 2686 0.212384436779817 3892 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2504 purpurogallin 52.29 µM -0.798988105168216 0.199998521179031 no 2687 0.212148654600096 3758 5281571 An antioxidant.
SGTC_1797 st048695 56.8 µM -0.800334805073698 0.199607391643644 no 2688 0.211758421371502 3794 592262 YIL048W NEO1
SGTC_2561 acetosyringone 100 µM -0.802713182476673 0.198917751614835 no 2689 0.21107026589415 3851 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_115 0527-0192 112.043 µM -0.803890384495324 0.19857693924587 no 2690 0.210730141879599 3868 4233931
SGTC_720 r052-1644 49.9 µM -0.804968956887002 0.198264990573765 no 2691 0.210418796921261 3840 1422863 YOR257W CDC31
SGTC_1658 st012944 20 µM -0.804992113462803 0.198258296388778 no 2692 0.210412115415149 3746 24207260
SGTC_3332 9141069 11.198 µM -0.805513591513879 0.198107581797517 no 2693 0.210261683202251 3787 17332883
SGTC_1326 1431-2094 10.8 µM -0.807128335411049 0.197641336728046 no 2694 0.209796274324504 3820 616278
SGTC_3334 9142812 21.919 µM -0.807364756248098 0.197573127707941 no 2695 0.209728182891982 3900 45283678
SGTC_2691 st077356 60.2 µM -0.807448769496034 0.197548892741576 no 2696 0.20970398941317 3905 2839272
SGTC_1472 k841-0093 193 µM -0.809640719327773 0.196917225027265 no 2697 0.209073348984528 3941 X1472
SGTC_1961 st076550 68.7 µM -0.811394840006311 0.196412611116844 no 2698 0.208569480717127 3869 1579337
SGTC_194 1486-1323 56.904 µM -0.811657037337598 0.196337251297741 no 2699 0.208494226519509 3881 5178754
SGTC_1328 1441-0025 69.2 µM -0.811737417732295 0.196314152162905 no 2700 0.208471159460762 3804 4562601
SGTC_1965 Pectolinarigenin 58.4 µM -0.815818229361479 0.195143604101887 no 2701 0.207302052756302 3840 5320438 An anti-inflammatory.
SGTC_2868 9035608 32.47 µM -0.817258616138437 0.194731455712039 no 2702 0.206890325598476 3820 6462614
SGTC_2474 5321570 43.32 µM -0.819304159156985 0.194147060350797 no 2703 0.206306450105888 3878 2841384
SGTC_755 1995-0008 37.3 µM -0.820029338936165 0.193940139018345 no 2704 0.206099691022881 3832 689533
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.821258128262779 0.193589825700356 no 2705 0.205749626302125 3871 689007
SGTC_3267 9137951 49.47 µM -0.821881103174589 0.193412370428492 no 2706 0.205572284422513 3870 16643986
SGTC_2694 st077685 81.9 µM -0.823046896711507 0.193080559253699 no 2707 0.205240662605399 3855 2838096
SGTC_2200 6600604 21.907 µM -0.823150988156457 0.193050949388256 no 2708 0.205211068200396 3825 2904777
SGTC_362 0310-0100 9.03 µM -0.825598767070372 0.192355453328425 no 2709 0.20451586738698 3950 790235
SGTC_2643 anethole 100 µM -0.826459979544645 0.192111118830914 no 2710 0.204271605625226 3870 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3113 9123498 49.47 µM -0.826876827586436 0.191992923149794 no 2711 0.204153439333184 3917 8897275
SGTC_1419 3993-2473 62.6 µM -0.829226602901607 0.191327486154442 no 2712 0.203488097086507 3929 704026
SGTC_2907 7721985 69.9 µM -0.831345513585652 0.190728641790633 no 2713 0.202889234991192 3913 3267881
SGTC_2844 9010103 25.97 µM -0.832606429830344 0.190372829475522 no 2714 0.202533365754163 3948 2480525
SGTC_3073 9114972 49.47 µM -0.833421332773749 0.190143092681574 no 2715 0.202303573785994 3837 41905075
SGTC_697 0508-1955 564 µM -0.835748864683363 0.189487855464866 no 2716 0.201648099565999 3852 6243113
SGTC_2330 7979373 200 µM -0.836811329070724 0.189189217303474 no 2717 0.20134931415257 3839 1863007
SGTC_2389 9091542 195.52 µM -0.836955482532751 0.189148720897045 no 2718 0.201308795882318 3880 3626624 YOL127W RPL25
SGTC_2720 fluspirilene 36.88 µM -0.837294539087411 0.189053492255832 no 2719 0.201213514041507 3878 3396 An atypical antipsychotic.
SGTC_3356 9151811 4.48 µM -0.838244568735386 0.188786820849985 no 2720 0.200946680310169 3876 1859254 YPR165W RHO1
SGTC_2291 7917025 104.35 µM -0.838839083602516 0.188620059712411 no 2721 0.200779807653117 3837 2964612
SGTC_1897 st060201 15 µM -0.83917772264962 0.188525112230428 no 2722 0.200684793230468 3937 611878
SGTC_2353 9059630 146.67 µM -0.840160327786555 0.18824977665926 no 2723 0.20040924938446 3938 4779114
SGTC_137 0438-0332 85.389 µM -0.840344164888344 0.188198291270422 no 2724 0.200357722711417 3892 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_687 k029-0044 34.9 µM -0.840939350593798 0.188031663270741 no 2725 0.200190956041903 3945 5829338
SGTC_2947 9072639 7.68 µM -0.841956684250148 0.187747061809732 no 2726 0.199906099841644 3935 16488146
SGTC_1936 st074407 74.3 µM -0.84243630921763 0.187612977946783 no 2727 0.199771888132091 3932 809813
SGTC_2654 protoveratrine a 100 µM -0.843284650072683 0.187375960858222 no 2728 0.199534632762282 3882 5702278 A heart drug and vasodilator.
SGTC_1886 st057356 49.9 µM -0.84424128577826 0.187108909538975 no 2729 0.199267294130444 3861 24207747
SGTC_488 nitrendipine 139 µM -0.844992668552984 0.186899321115406 no 2730 0.199057466213928 3933 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_377 3970-0964 33.1 µM -0.846305747946334 0.186533403677721 no 2731 0.198691101071041 3875 16481235
SGTC_2751 anetholtrithion 17.25 µM -0.846346557897334 0.18652203823204 no 2732 0.198679721116467 3915 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_24 0417-1663 219 µM -0.847298759911649 0.186256974656156 no 2733 0.198414308844463 3870 4329390
SGTC_1048 3161-0300 24.5 µM -0.847467659476173 0.186209982628058 no 2734 0.198367252930193 3887 2165101
SGTC_2134 5324836 1.464 µM -0.849366282205389 0.185682244542681 no 2735 0.197838754534644 3872 699272
SGTC_1297 1068-0111 14.1 µM -0.849566352481191 0.185626687428187 no 2736 0.1977831127947 3858 767057
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.851789426380965 0.18501006070382 no 2737 0.197165488008636 3948 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_438 sphingosine 6.67 µM -0.853445927899141 0.184551415866762 no 2738 0.196706030657294 3878 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3151 9099821 49.47 µM -0.854492289379998 0.184262068637821 no 2739 0.19641613994317 3869 17174189
SGTC_2071 5230951 39.92 µM -0.855309513397059 0.184036280565453 no 2740 0.196189911129791 3942 1799272
SGTC_1353 1498-1206 8.11 µM -0.856328236489274 0.183755062305056 no 2741 0.195908123490941 3961 6756808
SGTC_2263 7948595 193.29 µM -0.856617603445708 0.183675231472302 no 2742 0.19582812688863 3887 2971371
SGTC_935 2996-0153 430 µM -0.857083520133844 0.183546739346328 no 2743 0.195699364100603 3915 23738523
SGTC_2312 7706453 155.7 µM -0.858012177258509 0.183290798213683 no 2744 0.195442869685331 3939 976098
SGTC_1078 idebenone 36.1 µM -0.858622585487732 0.183122688860369 no 2745 0.19527438665059 3977 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_730 1436-0052 41.2 µM -0.859533707580884 0.182871940459045 no 2746 0.195023065718549 3922 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_982 1491-0518 27.5 µM -0.861084020230033 0.182445774291603 no 2747 0.194595884779288 3851 3091256
SGTC_348 k064-0012 10.7 µM -0.864219311626855 0.181585810504972 no 2748 0.193733712757548 3835 5066323
SGTC_1761 st044296 37 µM -0.864531877834035 0.181500217519588 no 2749 0.193647888199396 3921 1826700
SGTC_1669 st015249 58.4 µM -0.864609690802783 0.181478913178926 no 2750 0.193626525887204 4002 722793
SGTC_2583 asiatic acid 100 µM -0.86815168554227 0.180510811504802 no 2751 0.192655649727558 3921 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2488 5268135 45.7 µM -0.872239431390897 0.179397579174563 no 2752 0.191538886167442 3996 1270356 YLR208W SEC13
SGTC_2005 4024620 188 µM -0.874298471691667 0.178838470660559 no 2753 0.190977865708358 3913 236743
SGTC_2593 nobiletin 86.24 µM -0.876845331348581 0.178148419633588 no 2754 0.190285326608409 3965 72344 An anti-infammatory.
SGTC_532 1548-0774 215 µM -0.877030316122917 0.178098364968561 no 2755 0.190235085930579 4091 5932993
SGTC_2399 5884133 200 µM -0.879906755544991 0.177321175998249 no 2756 0.189454912376351 3967 722445
SGTC_2581 avocatin a 64 µM -0.880505449827787 0.177159683652522 no 2757 0.189292777078215 3935 6710728 A skin care supplement.
SGTC_2112 5488546 200 µM -0.881558578358996 0.176875837312975 no 2758 0.189007781598886 3907 600757
SGTC_1077 5-fluorocytosine 377 nM -0.882272306495402 0.176683631970578 no 2759 0.188814784305138 3962 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_826 1683-5028 118 µM -0.883052164195084 0.176473769129551 no 2760 0.188604043995158 4011 722377
SGTC_1457 k015-0032 57.3 µM -0.889649892354107 0.174704608377708 no 2761 0.18682695367227 3960 4302660
SGTC_1711 st032263 62.8 µM -0.889754385613141 0.174676679712302 no 2762 0.186798892156808 3948 3958979
SGTC_135 0933-0004 26.348 µM -0.893206957070983 0.173755480580703 no 2763 0.185873176562729 3963 21230617 YGL099W LSG1
SGTC_1417 3966-0327 90.4 µM -0.894497326481862 0.173411984961088 no 2764 0.185527929788639 4037 651118
SGTC_167 3672-0051 66.205 µM -0.894786693166238 0.173335015086342 no 2765 0.185450562505625 3889 3237971
SGTC_3110 9122132 49.47 µM -0.894965963976689 0.173287340994489 no 2766 0.185402641343019 4068 918317
SGTC_2416 tofa 880 nM -0.895429032602522 0.173164234231295 no 2767 0.185278893317293 4003 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1842 st055362 61.2 µM -0.896743162748202 0.172815176233454 no 2768 0.184927991470725 3934 676032
SGTC_2191 5911152 200 µM -0.898090710034826 0.172457708038093 no 2769 0.184568595678146 3973 2875902
SGTC_1165 k072-0275 30.3 µM -0.898504670934253 0.172347990058695 no 2770 0.184458278062675 3940 6153523 YGL055W OLE1
SGTC_2311 7694451 200 µM -0.899754547623257 0.172016987629691 no 2771 0.1841254438175 3935 2163142
SGTC_2815 7968870 71.43 µM -0.900507727455954 0.171817720558824 no 2772 0.183925057427876 3963 2977326 YHR190W ERG9
SGTC_656 4090-1979 187 µM -0.903165204404272 0.171115816214776 no 2773 0.18321911100792 4024 22330961
SGTC_921 1561-0023 372 µM -0.903431929558139 0.171045469016726 no 2774 0.183148350145467 3934 24050882
SGTC_1294 1000-1494 117 µM -0.905210551815316 0.170576840872503 no 2775 0.182676926419374 3966 712797 YDL207W GLE1
SGTC_482 fipronil 114 µM -0.906501190686561 0.170237300879243 no 2776 0.182335317473957 4041 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1609 st001574 46.4 µM -0.906635664431113 0.170201948586075 no 2777 0.182299747662621 3963 3960012
SGTC_1943 st076331 65.2 µM -0.907447015050061 0.169988749482887 no 2778 0.182085228353017 4003 24208415
SGTC_1340 1486-1359 257 µM -0.908122057631826 0.16981149864992 no 2779 0.181906868910486 3910 4309068
SGTC_3115 9123671 49.47 µM -0.908733060396163 0.169651165440528 no 2780 0.181745524281087 4071 3286988
SGTC_1377 2944-0135 198 µM -0.908878073509752 0.169613126818528 no 2781 0.181707244499372 4034 1894137
SGTC_1193 1488-0126 41.5 µM -0.909116838275287 0.16955050797223 no 2782 0.181644227652482 3979 1384710
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.909215438826711 0.169524653154732 no 2783 0.181618208138687 3918 6708514
SGTC_2696 st077691 74.316 µM -0.913760865362322 0.168335508299512 no 2784 0.180421257047933 4040 757133
SGTC_862 0452-0056 10.2 µM -0.916465183351749 0.167630573954673 no 2785 0.179711480269896 3945 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1149 3909-7961 23.3 µM -0.917023053215336 0.167485390973848 no 2786 0.179565280014921 4014 735261
SGTC_3272 9137413 49.47 µM -0.918872432426743 0.167004678445696 no 2787 0.179081150378136 3932 17614870
SGTC_2999 9069765 71.4286 µM -0.920409555872932 0.166605808929133 no 2788 0.178679388436114 3995 2097066
SGTC_3225 9130819 49.47 µM -0.923745224787712 0.165742350009366 no 2789 0.177809489923337 3939 4547121
SGTC_2564 betulinic acid 100 µM -0.924181871845355 0.165629535700807 no 2790 0.177695816188877 4075 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1255 0566-0045 221 µM -0.92434224462376 0.165588113462351 no 2791 0.177654077342588 4038 2788469
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.925346764550678 0.165328811230259 no 2792 0.177392780313275 4010 165521
SGTC_722 3534-0461 190 µM -0.928574956330691 0.164497280403389 no 2793 0.176554702773039 4056 658262
SGTC_2807 7945238 51.95 µM -0.928726696878551 0.16445826127014 no 2794 0.176515370812713 4060 17148797
SGTC_1942 st076330 65.2 µM -0.928917427230146 0.164409224662961 no 2795 0.176465940348732 4036 24208414
SGTC_1242 0402-0103 60.1 µM -0.929072956747783 0.164369245176047 no 2796 0.176425639159785 3941 432868
SGTC_1980 st071811 45.7 µM -0.931221176820243 0.163817681402479 no 2797 0.175869582851555 4098 4974850
SGTC_2402 5553605 200 µM -0.93184856975993 0.163656822754423 no 2798 0.175707394893602 4103 6758546
SGTC_2452 5863136 48.41 µM -0.937410571954194 0.162235255001259 no 2799 0.174273702461411 3982 2184096
SGTC_2840 9008771 71.43 µM -0.937852923791936 0.162122542384722 no 2800 0.174159999391906 3966 2992978
SGTC_2796 7949634 45.45 µM -0.938541133485649 0.161947285835161 no 2801 0.173983194253878 3966 2971588
SGTC_3091 9116372 49.47 µM -0.942365441284823 0.160975653229761 no 2802 0.173002787083011 4100 17169793
SGTC_1493 4348-0038 111 µM -0.944594443988954 0.160411094685286 no 2803 0.172432982315215 4008 800424
SGTC_113 0099-0221 2.5 µM -0.944971622360362 0.160315691635849 no 2804 0.172336681942848 3945 89219
SGTC_402 epigallocatechin gallate 10 µM -0.94649077274192 0.159931815073012 no 2805 0.171949163204096 3969 65064 An antioxidant.
SGTC_2634 4'-methoxyflavone 100 µM -0.947280897880017 0.159732394928626 no 2806 0.171747830978525 4041 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1660 st012960 28.1 µM -0.947317243349727 0.159723225590104 no 2807 0.171738573393033 4030 24207266
SGTC_2192 5915882 198.485 µM -0.954926585488855 0.15781110331106 no 2808 0.169807412135321 3986 2876149
SGTC_3158 9100007 49.47 µM -0.95516167673811 0.157752268542656 no 2809 0.169747971353474 4055 19297233
SGTC_2157 5649910 96.377 µM -0.956052764191828 0.157529392660342 no 2810 0.169522788791671 4029 2858091
SGTC_2307 7538926 6.34 µM -0.957130732931448 0.157260051338157 no 2811 0.1692506366298 4047 96582
SGTC_309 k408-0051 1.48 µM -0.958754529304806 0.156854901387369 no 2812 0.168841210480889 3979 3640463
SGTC_1230 0170-0365 3.77 µM -0.960623836531733 0.156389345720819 no 2813 0.168370669542461 4091 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1662 st014054 52 µM -0.962072129327722 0.156029271071849 no 2814 0.16800668651172 4082 2838777
SGTC_1675 st018485 24.5 µM -0.962914574542607 0.155820073833548 no 2815 0.167795197430519 4092 3323024
SGTC_2413 inermin 26.06 µM -0.963455419912924 0.155685867829733 no 2816 0.167659512947516 4155 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1390 3413-2614 145 µM -0.964022836563402 0.155545150362241 no 2817 0.167517238377916 4082 3421432
SGTC_3141 9094609 49.47 µM -0.965344916895803 0.155217604373192 no 2818 0.167186040586153 4002 25236309 YDL196W YDL196W
SGTC_1 0258-0098 57.368 µM -0.9671234018747 0.154777702634253 no 2819 0.166741174023462 3991 6790032 YDR047W HEM12
SGTC_2366 9070441 60.58 µM -0.968640367431992 0.154403138286294 no 2820 0.166362327540825 4057 6837235
SGTC_1479 0549-0158 134 µM -0.969901691005941 0.154092152937379 no 2821 0.166047748551554 4086 5440202
SGTC_1238 0333-0287 48.8 µM -0.972135234393733 0.153542479365796 no 2822 0.165491637729854 4017 7226
SGTC_1759 st043059 70 µM -0.972329952848301 0.153494620893459 no 2823 0.165443213609153 4067 669426
SGTC_2369 9071472 200 µM -0.972354153138292 0.153488673565597 no 2824 0.165437195930682 4129 17296037
SGTC_139 0099-0334 718.624 µM -0.972413705078886 0.153474039063776 no 2825 0.165422388263538 4096 97690
SGTC_605 1315-0399 119 µM -0.972949314450921 0.153342458082726 no 2826 0.165289246837318 4131 24020461
SGTC_2969 9091408 28.7 µM -0.975022897211691 0.152833754363003 no 2827 0.16477445110646 4010 4286311
SGTC_651 3253-0966 34.4 µM -0.975219436156234 0.15278559638475 no 2828 0.164725711526773 4068 781462
SGTC_2924 9010168 62.78 µM -0.97538560819983 0.152744887067032 no 2829 0.164684509904929 4149 2993929
SGTC_1916 st067606 49.2 µM -0.975693075595141 0.152669581769821 no 2830 0.164608292334976 4022 19590279
SGTC_1971 st069429 63.5 µM -0.978837884973359 0.151900765493579 no 2831 0.163830043669121 4034 1246522 YGL099W LSG1
SGTC_946 3434-1334 87.4 µM -0.981994307092112 0.1511317009754 no 2832 0.163051326419446 4062 4047976
SGTC_2122 5258151 111.688 µM -0.982808741197614 0.150933684713916 no 2833 0.162850789450904 4062 2173356
SGTC_3325 9138760 55.175 µM -0.983480017111468 0.150770604890338 no 2834 0.162685622748499 4005 43844959
SGTC_2467 5474540 200 µM -0.983884554788878 0.150672383148041 no 2835 0.16258613933572 4024 5413519
SGTC_577 r071-0003 38.6 µM -0.988129041790076 0.149644391057682 no 2836 0.161544727103638 4094 4568517 YMR134W ERG29
SGTC_2587 piperic acid 92.2 µM -0.989613921477986 0.149285868664404 no 2837 0.161181431408117 4077 5370536
SGTC_1442 4112-3290 3 µM -0.990570768241011 0.149055143284806 no 2838 0.160947608670492 4048 704353
SGTC_363 0455-0021 3.06 µM -0.993760924551458 0.148287619560425 no 2839 0.160169636991246 4065 4597466
SGTC_1696 st025591 34.7925 µM -0.994195893607243 0.148183174991806 no 2840 0.160063753450251 4085 2787147
SGTC_2129 girgensonine 121.053 µM -0.994624734100401 0.14808025020835 no 2841 0.159959406587381 4107 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_816 0325-0417 81.3 µM -0.99473317427349 0.148054231372101 no 2842 0.159933027620683 4099 68101
SGTC_1009 4106-0057 9.87 µM -0.997350642500595 0.147427131475864 no 2843 0.159297170091875 4091 2928005
SGTC_419 nsc-638432 893 µM -0.999226962787819 0.146978694508258 no 2844 0.158842378604984 4048 368090
SGTC_94 0334-0113 514.748 µM -0.999335275197497 0.146952836005831 no 2845 0.158816151331999 4114 6795178
SGTC_866 0495-0101 262 µM -1.00193165427832 0.146333889679749 no 2846 0.158188301577191 4058 635694
SGTC_1145 3546-0597 10.2 µM -1.00401202670049 0.145839218244733 no 2847 0.157686408342462 4071 875334
SGTC_246 cycloheximide 667 µM -1.00453670576711 0.145714637607145 no 2848 0.157559994025862 3979 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1608 st001473 40.5 µM -1.00943828127685 0.144554256063706 no 2849 0.156382243528596 4070 7292267
SGTC_1671 st016596 74.5 µM -1.01351627005903 0.143593604435083 no 2850 0.155406814363469 4156 2829167
SGTC_1356 1502-0781 85.8 µM -1.01605673130958 0.142997331261809 no 2851 0.154801185966262 4096 567702
SGTC_1161 k007-0610 110 µM -1.01612460163015 0.142981424357633 no 2852 0.15478502756398 4079 5843850
SGTC_2730 imipramine 71.33 µM -1.01648044168951 0.142898044972429 no 2853 0.154700328257163 4075 3696 A tricyclic antidepressant.
SGTC_1712 st032288 53.4 µM -1.01649049797005 0.142895689092211 no 2854 0.154697935042569 4003 2883011
SGTC_772 k072-0172 35.3 µM -1.01923961411026 0.142252639238749 no 2855 0.154044612088088 4152 5861980
SGTC_1889 st059080 5.18 µM -1.019270047275 0.142245531547479 no 2856 0.15403738992705 4058 176925 Isolated from Daphnopsis sellowiana.
SGTC_901 1112-0062 60.1 µM -1.02029660017848 0.142005920012695 no 2857 0.153793907632457 4128 1908457
SGTC_1278 0874-0585 172 µM -1.02062637958158 0.14192900299651 no 2858 0.153715743209369 4171 766306
SGTC_2194 5927483 104.545 µM -1.02159235117628 0.141703864270902 no 2859 0.153486939669892 4131 760979
SGTC_1380 2291-0730 164 µM -1.02745596310507 0.140342426217354 no 2860 0.15210290563656 4151 2999191
SGTC_2816 7982706 58.44 µM -1.02856481478333 0.140085970420215 no 2861 0.151842109497808 4146 2981853
SGTC_1852 st056254 31.4 µM -1.02882322087635 0.140026251897452 no 2862 0.151781376441962 4039 442583
SGTC_423 5-fluorouracil 457 µM -1.02953876158936 0.139860978295402 no 2863 0.151613287507595 4058 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1553 gossypol 38.6 µM -1.0318838943591 0.139320235712626 no 2864 0.151063255837927 3980 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2414 st077232 92.9 µM -1.03515693121051 0.138567917117562 no 2865 0.15029781432452 4068 729801
SGTC_519 k048-0011 62.8 µM -1.03581259298361 0.138417544437391 no 2866 0.150144790719905 4165 6836379
SGTC_956 1185-0240 191 µM -1.03614682982028 0.138340931737968 no 2867 0.150066823824445 4108 1416193
SGTC_2204 7233102 200 µM -1.0414840658448 0.137121462962594 no 2868 0.148825472313866 4040 2172480
SGTC_1264 0783-0040 158 µM -1.04196158927796 0.137012715909598 no 2869 0.148714743789824 4024 2855798
SGTC_2045 5106652 78.05 µM -1.04226090587739 0.136944582192405 no 2870 0.148645366095036 4098 673349
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.04281672935165 0.136818121005537 no 2871 0.148516590846391 4172 6708561
SGTC_1280 0880-0253 10.1 µM -1.04310301961785 0.136753015282448 no 2872 0.148450291169077 4117 6836607
SGTC_1505 k297-0037 20.6 µM -1.04353253755671 0.136655377657313 no 2873 0.14835085966744 4136 4089396
SGTC_1331 1472-0049 76.2 µM -1.04675392698187 0.135924613770432 no 2874 0.147606542411884 4069 24051409
SGTC_2033 5192550 145 µM -1.04760431636086 0.135732152338074 no 2875 0.147410473977992 4149 182073
SGTC_470 aa-861 153 µM -1.04820817771598 0.135595598890819 no 2876 0.147271351825229 4122 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1937 st074714 47.2 µM -1.04838128957564 0.135556469817051 no 2877 0.147231485239773 4096 17250970
SGTC_798 1287-0182 476 µM -1.05253154849806 0.134620688099864 no 2878 0.146277871981959 4178 1649755
SGTC_2772 vinpocetine 57.06 µM -1.05272287886022 0.134577654962786 no 2879 0.146234009864468 4179 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1358 1509-0022 2.48 µM -1.05361699097489 0.134376680583674 no 2880 0.146029153475968 4184 3258434
SGTC_2837 9008476 45.46 µM -1.05370380277909 0.134357178410287 no 2881 0.146009273679635 4170 2992805
SGTC_2838 9002687 71.43 µM -1.05385914008151 0.134322286911886 no 2882 0.145973706166483 4136 6457060
SGTC_9 0092-0002 10.449 µM -1.05396087700888 0.134299438375772 no 2883 0.145950414662644 4122 759368
SGTC_953 1188-0045 9.7 µM -1.05496830514427 0.134073329714376 no 2884 0.145719910332935 4167 6144426
SGTC_3301 9125354 19.7965 µM -1.05934723286869 0.133093556668208 no 2885 0.144720835735392 4121 41905162
SGTC_1839 st053978 48 µM -1.05974892843333 0.133003925793699 no 2886 0.144629418420639 4164 3788398
SGTC_2356 9061756 188.97 µM -1.06055843885043 0.132823424906383 no 2887 0.144445309379805 4181 20104043
SGTC_3116 9124943 49.47 µM -1.06235173914892 0.132424164065116 no 2888 0.144038017134912 4137 41905195 YPL160W CDC60
SGTC_2727 riluzole 51.77 µM -1.06420151494772 0.132013196852201 no 2889 0.14361871044312 4175 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2521 angolensin 13.4 µM -1.06699078175061 0.131395166247862 no 2890 0.14298799930046 4194 821428 A flavenoid.
SGTC_1425 4048-4433 7.33 µM -1.06783819585612 0.131207797115046 no 2891 0.142796752621202 4218 23734946
SGTC_2421 5690543 90.72 µM -1.06801878015823 0.131167892538521 no 2892 0.142756020232968 4176 3397993
SGTC_1604 st002052 72.4 µM -1.06852769105726 0.131055481166653 no 2893 0.142641273134199 4241 6254834 YHR062C RPP1
SGTC_858 0438-0351 2.77 µM -1.07039054805333 0.130644569639413 no 2894 0.14222177600143 4130 2799119
SGTC_900 1112-0045 141 µM -1.07190999535345 0.130310068127697 no 2895 0.141880230142055 4031 56211 YIL048W NEO1
SGTC_1186 1319-0216 26 µM -1.07232304789647 0.130219238434788 no 2896 0.141787479060949 4235 4565136
SGTC_805 3852-0218 479 µM -1.07506658657552 0.129617049820823 no 2897 0.141172458875413 4136 6615355
SGTC_531 3788-1495 174 µM -1.07863911365407 0.128835798947623 no 2898 0.140374318883304 4143 2896655
SGTC_2049 5262831 67.185 µM -1.08074633121417 0.128376520900846 no 2899 0.13990498380109 4174 763417
SGTC_2293 7624732 200 µM -1.08092518248252 0.128337591817482 no 2900 0.139865197882009 4063 894453
SGTC_3192 9110362 49.47 µM -1.08162457879579 0.128185438675913 no 2901 0.139709689234691 4195 16649480
SGTC_572 0960-0087 17.7 µM -1.08631488992182 0.127168302225302 no 2902 0.138669850796571 4156 6796365
SGTC_350 k064-0020 19.8 µM -1.08699394270612 0.127021510131566 no 2903 0.138519743338786 4213 2790705
SGTC_3289 9119912 71.43 µM -1.08700435482234 0.127019260243535 no 2904 0.138517442559143 4226 17014829
SGTC_1122 capsaicin 818.572 nM -1.08917176998314 0.126551520956565 no 2905 0.138039072673101 4235 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3033 9090887 49.47 µM -1.09497471444045 0.125305126654026 no 2906 0.136763857142833 4205 19325384
SGTC_2775 cyproheptadine 69.59 µM -1.09538104340892 0.125218174843731 no 2907 0.136674867741756 4188 2913 A selective serotonin reuptake inhibitor.
SGTC_1446 4239-0190 62 µM -1.09640339898566 0.124999583651516 no 2908 0.136451138578433 4201 1340085
SGTC_2136 5328288 199.296 µM -1.09964614887863 0.124308011127422 no 2909 0.135743163186428 4186 262395
SGTC_1670 st016595 4.04 µM -1.10162972136522 0.123886301443089 no 2910 0.135311340803351 4215 597879
SGTC_2714 st079313 56.9 µM -1.10360745443784 0.123466831170841 no 2911 0.13488172807045 4180 2939799
SGTC_2199 6590217 200 µM -1.10855661964167 0.122421493463554 no 2912 0.133810750471591 4088 703109
SGTC_125 0133-0007 11.75 µM -1.10869704139112 0.122391925178445 no 2913 0.133780449337744 4281 26541
SGTC_653 0203-0016 55.2 µM -1.11073163685818 0.121964067439435 no 2914 0.133341940116822 4258 295302
SGTC_444 curcumin 90.4 µM -1.11113346309772 0.121879691251779 no 2915 0.133255452983228 4136 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_91 0417-1751 58.384 µM -1.11191776276139 0.121715120759807 no 2916 0.133086755334794 4305 6795624
SGTC_2635 hydroquinidine 100 µM -1.11436917749513 0.121201744590418 no 2917 0.132560420323635 4125 442912 An experimental heart treatment.
SGTC_981 1488-1094 54.9 µM -1.11491225998865 0.121088218425693 no 2918 0.13244401122095 4177 3449522
SGTC_2737 bleomycin 30.5 nM -1.11784092299381 0.12047729904816 no 2919 0.13181747004658 4273 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_262 fenpropimorph 62.5 µM -1.11920769414822 0.120192934586016 no 2920 0.131525771881197 4187 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2489 cantharidin 73.42 µM -1.11947905425924 0.120136532896024 no 2921 0.131467910889753 4166 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_892 0929-0076 29 µM -1.11954745136332 0.120122319629661 no 2922 0.131453329631966 4187 5751038
SGTC_1484 3473-2379 286 µM -1.12096261181092 0.119828507954777 no 2923 0.131151888720723 4339 671917
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.12372604458319 0.119256233333723 no 2924 0.130564631982393 4234 2374 Ca(2+)-ATPase inhibitor.
SGTC_66 0109-0187 42.4 µM -1.12410076430252 0.119178782027642 no 2925 0.130485140559367 4097 759417
SGTC_2571 chrysanthemic acid 100 µM -1.12465213185025 0.119064883723062 no 2926 0.130368236696258 4220 2743 An insecticide.
SGTC_1474 0330-0125 5.35 µM -1.12628730341468 0.11872755147938 no 2927 0.130021965087316 4234 X1474
SGTC_3326 9140064 16.379 µM -1.12716030351355 0.11854773022349 no 2928 0.129837355384905 4138 1868434
SGTC_1773 st048542 73.5835 µM -1.12910705250154 0.118147430674685 no 2929 0.129426338298358 4175 3237138
SGTC_937 3122-0005 46.7 µM -1.13302225279145 0.117345265656589 no 2930 0.128602454261786 4248 759535
SGTC_3175 9106517 49.47 µM -1.13539425227955 0.116861159380792 no 2931 0.128105083425072 4247 41468073
SGTC_2508 celastrol 40.54 µM -1.1386424986034 0.116200517260861 no 2932 0.127426147511535 4171 122724 Celastrol is a natural product and antioxidant.
SGTC_1802 st050112 57.9 µM -1.13921525538961 0.116084302970816 no 2933 0.127306692103506 4226 4662563
SGTC_2459 5811157 9.22 µM -1.1408575633157 0.115751530632866 no 2934 0.126964600756915 4201 2870684 YBR192W RIM2
SGTC_2405 ticlatone 3.52 µM -1.14108807848542 0.115704876816021 no 2935 0.126916635897323 4065 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3350 9150499 3.57 µM -1.14136266301846 0.11564932126132 no 2936 0.12685951768843 4234 4910996 YPR165W RHO1
SGTC_2380 9035439 200 µM -1.14201110408982 0.115518200074905 no 2937 0.12672470205961 4334 6462575
SGTC_3204 9114183 49.47 µM -1.14401375345795 0.115113911572077 no 2938 0.12630896662692 4226 17027248
SGTC_2803 7707263 71.43 µM -1.14453638947411 0.115008569205368 no 2939 0.126200627754898 4210 2199229
SGTC_2195 6536160 144.242 µM -1.14619929977375 0.11467384962215 no 2940 0.125856348783587 4207 3834386
SGTC_768 0384-0033 77.3 µM -1.14709891922861 0.11449305857119 no 2941 0.125670370254278 4194 3965305 YMR134W ERG29
SGTC_1523 st012844 44.7 µM -1.14737130829868 0.114438358233537 no 2942 0.125614097036661 4323 4274103
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.14751344015482 0.114409823137784 no 2943 0.125584740810548 4284 91467 include heat shock
SGTC_2647 atorvastatin 60.16 µM -1.14823799767545 0.114264436110036 no 2944 0.125435163514018 4202 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1183 1254-0324 198 µM -1.14826486081953 0.114259048381512 no 2945 0.125429620291392 4315 5799357
SGTC_79 0052-0007 94.094 µM -1.14977822802582 0.113955816398991 no 2946 0.125117612354041 4241 2801472
SGTC_682 0kpi-0099 17 µM -1.15110431902104 0.113690580488611 no 2947 0.124844660691063 4260 1714895 YML126C ERG13
SGTC_2601 securinine 100 µM -1.1516978118943 0.113572016645105 no 2948 0.124722635870559 4217 442872 A GABA receptor antagonist.
SGTC_1591 genipin 88.4 µM -1.15603276199833 0.112708683782165 no 2949 0.123833878250316 4284 442424 A DNA cross-linking agent.
SGTC_1074 carmofur 3.8 µM -1.15632130691044 0.112651385030167 no 2950 0.123774878126123 4286 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3243 9134147 49.47 µM -1.15667289566234 0.112581595262062 no 2951 0.123703013736183 4346 24282180
SGTC_2446 5162541 200 µM -1.15817186410867 0.112284399074477 no 2952 0.123396953888367 4207 1549321
SGTC_2926 9010726 65.15 µM -1.15921224200388 0.112078456195851 no 2953 0.123184841316682 4272 2994293
SGTC_2836 9010338 19.48 µM -1.16102742373644 0.111719787667322 no 2954 0.122815373598339 4232 2994051
SGTC_1344 1488-0097 29.1 µM -1.1614988685312 0.111626767595513 no 2955 0.122719541524045 4296 747966
SGTC_1534 6-azauridine 81.6 µM -1.16269045920581 0.11139190366897 no 2956 0.122477556974685 4275 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_583 1488-1091 88.9 µM -1.16340150553138 0.111251924209992 no 2957 0.122333319498867 4353 4303273
SGTC_1408 3909-7976 48.8 µM -1.16451552204699 0.111032867697385 no 2958 0.122107578341815 4299 24152374
SGTC_3246 9135460 32.98 µM -1.1647696718094 0.110982935837425 no 2959 0.122056119155871 4230 41446951
SGTC_3129 9127257 49.47 µM -1.16577392903806 0.110785790491672 no 2960 0.121852930320798 4204 837894
SGTC_1201 1889-3372 45.9 µM -1.16839068568894 0.110273275076394 no 2961 0.121324605162428 4127 5392199
SGTC_481 bay k-8644 50 µM -1.16918392600831 0.110118248180498 no 2962 0.12116476795881 4232 2303 A calcium channel antagonist.
SGTC_2968 9090663 33.37 µM -1.17179349467296 0.109609350556286 no 2963 0.12063998756092 4218 25236811
SGTC_1731 st035964 63 µM -1.17179894170562 0.109608290087675 no 2964 0.120638893846889 4184 6739575
SGTC_948 3448-0295 75.3 µM -1.17248206815715 0.109475352366903 no 2965 0.120501783675117 4239 678569
SGTC_284 0988-0104 32.6 µM -1.17437491548697 0.109107605676707 no 2966 0.120122444089392 4237 4666532
SGTC_3248 9135562 49.47 µM -1.17476469877815 0.109031988048022 no 2967 0.12004443344575 4243 17650701
SGTC_2785 7756463 72.73 µM -1.1757129562128 0.108848184209439 no 2968 0.119854799739202 4232 2201551
SGTC_965 1291-5240 308 µM -1.17746573551037 0.108509023945091 no 2969 0.119504832954633 4282 2834598
SGTC_2814 7977482 42.97 µM -1.17927346863201 0.108160027274156 no 2970 0.11914464968634 4281 6456762
SGTC_1308 1187-1617 41.4 µM -1.18522481430168 0.107016785014167 no 2971 0.117964285652171 4292 2882570
SGTC_457 grayanotoxin iii 135 µM -1.18702694718249 0.106672324152638 no 2972 0.117608495749515 4121 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1274 0865-0114 173 µM -1.18729383803127 0.106621378568019 no 2973 0.117555868905194 4278 870624
SGTC_2759 disulfiram 3.38 µM -1.18773328849927 0.106537532129253 no 2974 0.117469252238889 4177 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1444 4112-3581 28 µM -1.19249274458372 0.105632483737101 no 2975 0.116534046977178 4337 2877249
SGTC_2441 5730946 39.09 µM -1.19272739153555 0.105588007990487 no 2976 0.11648807720139 4328 1774275
SGTC_2552 juarezic acid 87.02 µM -1.19951496065205 0.104307325911156 no 2977 0.115163885511719 4230 1549512
SGTC_1281 0884-0031 11.8 µM -1.20048195287313 0.104125793411982 no 2978 0.114976108756149 4309 1548255
SGTC_1215 3852-0577 11.2 µM -1.20083227206973 0.104060084885197 no 2979 0.114908135288504 4329 2884876
SGTC_3240 9133527 49.47 µM -1.20342314192585 0.103575054904784 no 2980 0.114406308493935 4242 17617455
SGTC_2929 9013348 24.6 µM -1.20505551112663 0.103270306980715 no 2981 0.114090936437016 4272 2995952
SGTC_339 3091-4833 71.4 µM -1.20516491022526 0.103249906503717 no 2982 0.114069822806926 4145 3240077
SGTC_202 3594-0513 34.79 µM -1.20607249145472 0.103080775795045 no 2983 0.113894770237132 4347 708429
SGTC_1863 st057641 20.1 µM -1.20610991398699 0.103073806306791 no 2984 0.113887556360635 4309 3921635
SGTC_752 1896-0090 130 µM -1.20861464214628 0.102608109130309 no 2985 0.113405464229325 4285 772567
SGTC_1849 st056239 19.2 µM -1.21083910180478 0.102195805472656 no 2986 0.112978537960853 4283 5393181
SGTC_1027 k015-0025 8.67 µM -1.21618298278115 0.101210245034063 no 2987 0.111957612359767 4290 3598955
SGTC_2931 9014674 55.67 µM -1.21821413976923 0.100837465452178 no 2988 0.111571303874335 4261 2996810
SGTC_2140 5586273 200 µM -1.21822804004867 0.100834917778561 no 2989 0.111568663451423 4266 854421
SGTC_1463 k081-0032 34.1 µM -1.22107848411325 0.100313473324053 no 2990 0.111028152626084 3887 977755
SGTC_1870 st057514 26.5 µM -1.22274843847173 0.100008896818464 no 2991 0.110712362812487 4295 5393161
SGTC_2099 5377090 177.372 µM -1.22331539072585 0.0999056462969775 no 2992 0.110605298143639 4319 2243829
SGTC_1199 1638-0010 4.46 µM -1.22337524956346 0.0998947496490304 no 2993 0.110593998585023 4274 3111136
SGTC_835 0312-0010 67.2 µM -1.22352488331669 0.0998675142548448 no 2994 0.110565755826253 4309 1626196
SGTC_595 3909-8003 73.7 µM -1.22509290100939 0.0995824396856485 no 2995 0.110270109803197 4372 699517
SGTC_1594 piperine 70.1 µM -1.22519705874352 0.0995635242991996 no 2996 0.110250491209381 4287 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2996 9066192 71.4286 µM -1.22817174002775 0.0990244202099675 no 2997 0.109691252435893 4325 6472854
SGTC_2092 5303694 80.6725 µM -1.22892590369586 0.0988880823919455 no 2998 0.109549794162499 4303 1963699
SGTC_2681 menadione 3.18 µM -1.22915075674289 0.0988474600157661 no 2999 0.109507643899509 4329 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2476 5806916 10.51 µM -1.22943134515525 0.0987967855102089 no 3000 0.109455061992078 4196 2870194
SGTC_2072 5231554 129 µM -1.22954103696962 0.0987769802448269 no 3001 0.10943451081812 4347 789545
SGTC_1515 3460-0031 42.1 µM -1.23098326993981 0.0985168498968296 no 3002 0.109164560781194 4261 2876596
SGTC_1478 0453-0656 35.7 µM -1.23336254734481 0.0980888050329498 no 3003 0.108720265824006 4313 5258496
SGTC_2789 5281112 71.43 µM -1.24474234351038 0.0960603539216133 no 3004 0.106613237894069 4325 765948
SGTC_1220 1838-0075 193 µM -1.24587838780184 0.0958595596000416 no 3005 0.10640452280109 4249 5529645
SGTC_1250 0485-0349 40.2 µM -1.24641003280227 0.0957656981639013 no 3006 0.106306949904981 4347 6842794 YDL195W SEC31
SGTC_3295 9122362 53.5725 µM -1.24900544413204 0.0953084512455424 no 3007 0.105831541319442 4324 4730473
SGTC_1227 3909-8010 46.6 µM -1.25060524284189 0.0950274083995147 no 3008 0.10553926842893 4314 15982272
SGTC_2244 6635614 200 µM -1.2572921826288 0.0938592948803665 no 3009 0.104323926834849 4262 836499
SGTC_293 4049-0273 38.5 µM -1.2585947826049 0.0936329877649751 no 3010 0.104088366251853 4210 1380311
SGTC_433 pimozide 108 µM -1.26455069351271 0.0926033693325792 no 3011 0.103016218790138 4259 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2626 ethyl orsellinate 100 µM -1.26520482778077 0.092490799361719 no 3012 0.102898956146541 4294 75653 A natural product.
SGTC_1485 3909-9022 254 µM -1.26522240569525 0.0924877757757753 no 3013 0.10289580640004 4396 714516
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.26591743454918 0.0923682821163505 no 3014 0.102771321897733 4433 688664
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.26607991050724 0.0923403647274489 no 3015 0.102742237112639 4384 368090
SGTC_394 menadione 8.33 µM -1.26888245059958 0.0918598013635613 no 3016 0.102241496186162 4347 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1564 D-Arginine 115 µM -1.27278186173946 0.091194238176225 no 3017 0.101547729648527 4356 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_263 alizarin 107.927 µM -1.27280136316897 0.0911909186240896 no 3018 0.101544268674729 4380 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_967 1306-0166 352 µM -1.27359007849586 0.0910567378243193 no 3019 0.101404365123635 4364 4437607
SGTC_1822 st052468 42 µM -1.27435393811616 0.0909269252656194 no 3020 0.10126900440943 4352 2873678
SGTC_282 k297-0036 65.7 µM -1.27688450167223 0.0904978546602242 no 3021 0.100821513267289 4349 5061378
SGTC_1154 4088-0362 150 µM -1.2811278564661 0.0897817477380195 no 3022 0.100074380426922 4350 6618304
SGTC_1745 st081495 74 µM -1.28163158892805 0.0896970185272405 no 3023 0.0999859567498123 4207 13842402 YBL026W LSM2
SGTC_1765 st044815 90.4 µM -1.28329291398392 0.0894180003408868 no 3024 0.0996947371511677 4382 645695
SGTC_2126 5251174 33.877 µM -1.28461529142621 0.0891963699847461 no 3025 0.0994633762270325 4348 790722
SGTC_2138 5575593 77.673 µM -1.2948517558794 0.0874945513851395 no 3026 0.0976856869286727 4366 762213
SGTC_818 4072-2707 53.5 µM -1.29620143897529 0.0872719861821619 no 3027 0.0974530469654973 4268 882871
SGTC_1728 st035614 33.7865 µM -1.29703105002475 0.0871353917251787 no 3028 0.0973102517392892 4305 15945546
SGTC_1397 3532-0190 20.1 µM -1.29781322679664 0.0870067535478332 no 3029 0.0971757616988393 4308 5322280
SGTC_2070 5230947 200 µM -1.3019181435163 0.0863339765509784 no 3030 0.0964721847254945 4470 2835538
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.30442554373311 0.0859249435088533 no 3031 0.0960442652879391 4435 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1668 st014914 51.6 µM -1.30845217393652 0.0852711150706413 no 3032 0.0953599930646746 4385 2839556
SGTC_2173 5763948 167 µM -1.30845963277797 0.0852699074015732 no 3033 0.0953587288727251 4346 2867177
SGTC_2981 9013952 38.96 µM -1.31617438928383 0.0840276520754147 no 3034 0.0940577587776384 4334 2996344
SGTC_233 rapamycin 362 pM -1.31765127158949 0.0837913971307321 no 3035 0.0938102068356338 4371 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_336 4111-0029 111 µM -1.31853507572265 0.0836502549616595 no 3036 0.0936622956268846 4383 3131175
SGTC_2146 5545642 200 µM -1.31865470358978 0.0836311643073315 no 3037 0.0936422882501384 4339 825326
SGTC_3075 9116269 49.47 µM -1.32031291050525 0.0833668786272163 no 3038 0.0933652834266635 4389 17015205 YNL244C SUI1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.32190925748638 0.0831130457795007 no 3039 0.0930991846824056 4276 4330530
SGTC_2862 9027634 71.43 µM -1.32556397459422 0.082534103559335 no 3040 0.0924920828492515 4334 5012562
SGTC_3112 9123419 49.47 µM -1.3257275231876 0.0825082670387561 no 3041 0.0924649836739631 4441 17015854
SGTC_1567 st069303 68.4 µM -1.3332874935536 0.081320618525687 no 3042 0.0912187381413213 4414 5581319
SGTC_2958 9077254 16.72 µM -1.33461641569248 0.0811131882756374 no 3043 0.091000961253951 4437 16457351
SGTC_323 4013-0906 34.3 µM -1.33464104512208 0.081109347662449 no 3044 0.0909969287536885 4413 2910086
SGTC_889 0919-1524 82.7 µM -1.33932573136044 0.0803813294472525 no 3045 0.0902323277625029 4405 3905452
SGTC_2303 7774051 200 µM -1.34077780827717 0.0801566765012475 no 3046 0.0899963016769907 4397 2953184
SGTC_1051 3253-3903 78 µM -1.34151144875551 0.0800433545287182 no 3047 0.0898772275607854 4387 5509239
SGTC_665 3914-0008 307 µM -1.34251318034628 0.0798888174505054 no 3048 0.0897148298475834 4362 1069549
SGTC_471 1-acyl-paf 4 µM -1.3437049828832 0.0797052521739077 no 3049 0.0895219026913591 4358 16759367
SGTC_902 1120-0002 2.07 µM -1.34399338162806 0.0796608800527724 no 3050 0.08947526354633 4393 3280475
SGTC_3047 9092122 49.47 µM -1.34455089191384 0.0795751562642462 no 3051 0.0893851555742193 4363 17173831
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.34655183151759 0.079268062943779 no 3052 0.0890623082536947 4409 4174840
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.34827552832777 0.079004239409852 no 3053 0.0887848899948901 4399 5282362
SGTC_2962 9082311 13.18 µM -1.349878947392 0.0787594227670084 no 3054 0.0885274078438904 4372 16459453
SGTC_1824 st053723 68.6 µM -1.35173297162961 0.0784770598094482 no 3055 0.0882303766883915 4416 675225
SGTC_1352 1496-0991 99 µM -1.35424115309913 0.07809629266996 no 3056 0.0878297268020867 4404 3000039
SGTC_368 fentichlor 4.58 µM -1.35502924267916 0.0779769425800038 no 3057 0.0877041201779775 4407 7329 A pesticide.
SGTC_390 dec-rvkr-cmk 16.7 µM -1.35794263781395 0.0775369326348725 no 3058 0.0872409432551104 4450 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2662 daunorubicin 22.37 µM -1.35986908589639 0.0772470184377446 no 3059 0.0869356776477159 4296 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3120 9124077 49.47 µM -1.36537508671686 0.0764229523077779 no 3060 0.0860675950153828 4528 18774327 YGL155W CDC43
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.3670216962406 0.0761778131400268 no 3061 0.085809252531647 4410 229346 A bile salt which induces apoptosis.
SGTC_843 0310-0051 143 µM -1.36974086425051 0.0757743076068612 no 3062 0.0853839038307104 4441 2065037
SGTC_1096 rimcazole 32.2 µM -1.37101067139175 0.0755864356297971 no 3063 0.0851858147238925 4345 18528119 A dopamine reuptake inhibitor.
SGTC_2418 pentamidine 31.67 µM -1.37452167078616 0.0750688195242895 no 3064 0.0846398936322315 4372 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2270 7924575 90.91 µM -1.3755861782301 0.0749124176309325 no 3065 0.0844748941495866 4391 1262135
SGTC_92 0063-0024 660.874 µM -1.37608820835545 0.0748387435729772 no 3066 0.0843971628802248 4522 3594437
SGTC_326 k292-0812 17.5 µM -1.3776619094131 0.0746081575888371 no 3067 0.0841538484445067 4396 3579357
SGTC_3249 9135183 49.47 µM -1.37782471168278 0.0745843340279732 no 3068 0.0841287072039491 4387 4902779
SGTC_2707 st078556 66.6 µM -1.38362744599725 0.0737389811859831 no 3069 0.083236279947417 4357 17250899
SGTC_1718 roemerine 11.9335 µM -1.38454527919343 0.0736059430767968 no 3070 0.0830957768351378 4060 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1342 1486-1464 234 µM -1.39987177741733 0.0714114235376996 no 3071 0.0807758593993337 4444 3253938
SGTC_836 0330-0104 1.35 µM -1.40153578639001 0.0711762173587984 no 3072 0.0805269569502237 4460 46494820
SGTC_2703 st077852 53.4 µM -1.40637648440836 0.070495370742227 no 3073 0.0798061796539549 4467 6281836
SGTC_2378 9074213 121.43 µM -1.40683402361315 0.0704312774802851 no 3074 0.0797383055294453 4404 657714
SGTC_578 3460-0051 92 µM -1.4071090252227 0.0703927761130769 no 3075 0.0796975311477254 4500 2876744
SGTC_2959 9079155 11 µM -1.40790456437819 0.070281488444248 no 3076 0.0795796656797966 4455 16189457
SGTC_629 3448-6466 76.7 µM -1.41715706551141 0.0689970778263046 no 3077 0.0782185056857446 4455 573744
SGTC_1366 1683-0113 21.9 µM -1.41839640806982 0.0688264180378816 no 3078 0.0780375318590499 4429 708623
SGTC_2473 5854593 8.94 µM -1.42093633529378 0.0684776824469111 no 3079 0.0776676342837043 4367 2872951
SGTC_2470 5664817 21.68 µM -1.42494587668039 0.0679299432681471 no 3080 0.0770864234312554 4495 2859561
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.42807820455388 0.0675043980731714 no 3081 0.0766346750593329 4439 6312947
SGTC_2322 7413319 38.22 µM -1.42905041131793 0.0673727378430924 no 3082 0.0764948723766732 4409 1840400
SGTC_660 4031-1742 102 µM -1.43359128167273 0.066760421572018 no 3083 0.0758444664531344 4336 6738706
SGTC_2710 st078562 53.7235 µM -1.43359215116969 0.0667603047379468 no 3084 0.0758443423163939 4413 17250908
SGTC_2187 6125751 200 µM -1.43399647992568 0.0667059923333359 no 3085 0.0757866336878497 4479 874498
SGTC_97 0535-0701 19.132 µM -1.43520336222991 0.0665440783968426 no 3086 0.0756145779004487 4348 2832013 YGL099W LSG1
SGTC_1864 st057645 30.4 µM -1.43555484131808 0.0664969816140565 no 3087 0.0755645262687946 4492 688666
SGTC_1440 4100-1550 40 µM -1.43649114333028 0.0663716468415098 no 3088 0.075431317368435 4480 742806
SGTC_1905 st060207 84.5 µM -1.44200703143143 0.0656369915047283 no 3089 0.0746501950074389 4456 1948547
SGTC_547 1120-0019 610 nM -1.44239363382822 0.0655857377154097 no 3090 0.0745956793833992 4437 3676939
SGTC_1030 k029-0042 36.7 µM -1.44480963281865 0.0652661394479714 no 3091 0.0742556823018988 4441 6080581
SGTC_2776 terbinafine 19.92 µM -1.45086754834944 0.0644700867173384 no 3092 0.0734083729173889 4476 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_614 0462-0418 107 µM -1.45465009113768 0.0639768725804813 no 3093 0.0728830780314476 4243 5188303
SGTC_2595 hexamethylquercetagetin 100 µM -1.45882923935528 0.063435361233325 no 3094 0.0723060563821379 4462 386331
SGTC_1171 0368-0077 21.4 µM -1.45899349025129 0.0634141515799926 no 3095 0.0722834497030982 4458 3239779
SGTC_601 0986-0029 62.9 µM -1.46140388595002 0.063103532620162 no 3096 0.0719523174539406 4441 24747981
SGTC_1573 oleylamine 1.06 µM -1.46183304725235 0.0630483526360074 no 3097 0.0718934828579579 4466 5356789 An amine of the fatty acid oleic acid.
SGTC_480 am 92016 50 µM -1.4648079836079 0.0626668788526798 no 3098 0.0714866565441815 4500 2129 K+ channel blocker.
SGTC_2032 5185112 25.99 µM -1.47340555762265 0.0615745267346197 no 3099 0.0703208563017303 4362 5718189
SGTC_1052 3253-3998 198 µM -1.48059543194835 0.0606724934413986 no 3100 0.0693572066926869 4432 5450317
SGTC_664 1222-0054 14.9 µM -1.48224962456417 0.0604664301369179 no 3101 0.0691369434094668 4455 6813991
SGTC_993 3909-8757 62.7 µM -1.48400501203898 0.0602483602645442 no 3102 0.0689037954678644 4439 4288324 YLR208W SEC13
SGTC_678 1218-2179 85.9 µM -1.48949236643634 0.0595706407217731 no 3103 0.0681788809971508 4526 6820081 YOR116C RPO31
SGTC_785 1270-0111 65.3 µM -1.49033082633277 0.0594676144115559 no 3104 0.0680686354668105 4400 6741994
SGTC_1770 st043884 66.3 µM -1.49505467881596 0.0588897757867124 no 3105 0.0674500862694921 4502 670149
SGTC_380 3970-0968 6 µM -1.49512135934883 0.0588816508312718 no 3106 0.0674413862051261 4392 2891601
SGTC_2755 lomerizine 42.69 µM -1.497412574427 0.058603002614499 no 3107 0.0671429691931596 4433 3949 A calcium channel blocker.
SGTC_308 4092-1169 104 µM -1.49923906538835 0.0583816146806848 no 3108 0.0669058119472072 4460 2268590 YDL196W YDL196W
SGTC_2423 st077119 87.2 µM -1.50122178838223 0.0581420340496029 no 3109 0.0666491031306327 4413 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1612 st002233 45.4 µM -1.50443082577638 0.0577559104875876 no 3110 0.0662352360561664 4515 1035021
SGTC_407 eburnamonine 100 µM -1.50468232744315 0.0577257342543756 no 3111 0.0662028843797492 4346 3195
SGTC_144 4161-2749 112.381 µM -1.50620171270846 0.0575436955841448 no 3112 0.0660076999603736 4486 797501 YMR168C CEP3
SGTC_711 k292-0785 179 µM -1.51785093388845 0.0561629567194828 no 3113 0.0645259907925638 4450 4146315
SGTC_1615 st002656 86.5 µM -1.52071723462951 0.055827261626213 no 3114 0.0641654059098701 4511 1584458
SGTC_1806 st050005 60.3 µM -1.5253242400587 0.0552910183468531 no 3115 0.0635891223137005 4552 5194765
SGTC_2784 7567673 72.73 µM -1.53611611349674 0.0540507973068944 no 3116 0.0622549524866111 4433 3471247
SGTC_3224 9130643 49.47 µM -1.53680940338289 0.0539718820986457 no 3117 0.0621699950141022 4517 17644395
SGTC_2242 6630449 61.2675 µM -1.53846711507314 0.0537835592907506 no 3118 0.0619672215642237 4529 691249 YDR170C SEC7
SGTC_2817 7995342 71.43 µM -1.5402632995395 0.0535800932079601 no 3119 0.0617480929179349 4495 18879975
SGTC_925 2064-1272 59.6 µM -1.54596131635866 0.0529386731687996 no 3120 0.0610569552702516 4496 6815817
SGTC_1637 st007924 17.4 µM -1.54945372534176 0.0525485563076454 no 3121 0.060636343637243 4430 683336
SGTC_1017 4239-0030 168 µM -1.55058223363009 0.0524229860852791 no 3122 0.0605009162493945 4526 1149593
SGTC_649 1123-0311 367 µM -1.55400319350939 0.0520437876781251 no 3123 0.0600918274372848 4416 693629 YIL048W NEO1
SGTC_35 0133-0054 64.071 µM -1.55750572498496 0.0516578083410554 no 3124 0.0596752312033171 4486 99677
SGTC_1962 st076595 64.5 µM -1.55999077128643 0.0513853386936592 no 3125 0.059381031042475 4491 279619
SGTC_2943 9068529 45.32 µM -1.56047063120948 0.0513328569931473 no 3126 0.0593243524946251 4481 3270634
SGTC_2275 7947463 200 µM -1.56147443483161 0.0512232100940066 no 3127 0.0592059256306589 4477 1225414
SGTC_429 1112-0049 25.5 µM -1.57232234177504 0.0500501295664806 no 3128 0.0579379070935969 4491 2836170
SGTC_1530 rhein 70.4 µM -1.57591546561133 0.0496663302358122 no 3129 0.0575226431391699 4614 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2323 6148992 148.28 µM -1.57660557081123 0.0495928862109001 no 3130 0.0574431550701469 4491 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2053 5265679 138 µM -1.57740806230981 0.0495075905611581 no 3131 0.0573508307572739 4448 764595
SGTC_3200 9114385 49.47 µM -1.58032267139781 0.0491987855050366 no 3132 0.0570164952311222 4506 17018030 YLR208W SEC13
SGTC_2252 omeprazole 400 µM -1.58083926663953 0.0491442126717234 no 3133 0.0569573968782696 4574 4594 A proton pump inhibitor.
SGTC_1846 st056244 14.8 µM -1.58093078706396 0.0491345495483662 no 3134 0.0569469319981713 4554 5393182
SGTC_795 0685-0265 78 µM -1.58721557260381 0.0484745968847805 no 3135 0.0562319144901764 4542 302754
SGTC_1362 1611-0397 101 µM -1.59000499190499 0.0481839658768087 no 3136 0.055916839913011 4525 27816
SGTC_1857 st056007 79.3 µM -1.5932839937674 0.0478441095295846 no 3137 0.0555482478903425 4530 619834
SGTC_3310 9130229 44.1445 µM -1.59403165775615 0.0477668862564447 no 3138 0.0554644722284866 4552 7761258
SGTC_520 3584-0023 682 µM -1.59453908628348 0.0477145328366092 no 3139 0.055407671768288 4535 1340790
SGTC_2268 7933382 153.85 µM -1.59561434795079 0.0476037456660389 no 3140 0.055287461073049 4575 935025 YOR257W CDC31
SGTC_1063 disulfiram 1.84 µM -1.60120308636296 0.0470312369969896 no 3141 0.0546659727447039 4565 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1722 st034304 3.6505 µM -1.60222821542606 0.0469268247523635 no 3142 0.0545525764381091 4490 4036148 YLR033W RSC58
SGTC_2887 9044784 58.44 µM -1.60924750807414 0.0462168756929494 no 3143 0.053781115996101 4480 6465546
SGTC_2513 baicalein 25.65 µM -1.61517441450999 0.0456241525031135 no 3144 0.0531364647987295 4528 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1724 st037281 8.293 µM -1.61585688791055 0.0455562955525702 no 3145 0.0530626292990701 4497 574124 YDL195W SEC31
SGTC_528 3492-0019 172 µM -1.61630809889704 0.0455114771332647 no 3146 0.053013858331104 4548 2869262
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.61736782737633 0.0454063545853931 no 3147 0.0528994530724102 4617 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2163 5671233 125 µM -1.62025507660301 0.045120936920816 no 3148 0.0525887473374916 4503 701023
SGTC_2248 tofa 1.1 µM -1.62381692036533 0.0447708235665944 no 3149 0.0522074438781499 4583 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_584 0986-0246 15.4 µM -1.63103094201503 0.0440684202984422 no 3150 0.051441895372263 4635 53315 YDR232W HEM1
SGTC_231 b-estradiol 524 µM -1.63178415264175 0.0439955980388661 no 3151 0.0513624824488201 4567 450 A steroid.
SGTC_1683 st010134 710 nM -1.6334541478852 0.0438344848738101 no 3152 0.051186758362669 4522 3818134
SGTC_2000 st075254 36.4 µM -1.63394672773514 0.0437870541223747 no 3153 0.0511350184492823 4444 17234175
SGTC_453 enantio-paf c16 10 µM -1.63656845954961 0.0435353025042053 no 3154 0.0508603351970557 4171 13871343 A lipid and platelet activating factor
SGTC_375 3970-0961 9.27 µM -1.63712380957645 0.0434821252872506 no 3155 0.0508023012897647 4538 2898222
SGTC_1471 k673-0312 37 µM -1.64563465377341 0.0426737144329296 no 3156 0.0499195000259716 4546 24099884
SGTC_3140 9094243 49.47 µM -1.64736523853981 0.0425108290313577 no 3157 0.0497414979363629 4528 19291112
SGTC_552 k242-0005 476 µM -1.64941833701429 0.0423182406011034 no 3158 0.0495309803053514 4613 4088318
SGTC_1952 st077036 64.1 µM -1.64955777789583 0.0423051861562954 no 3159 0.0495167083454594 4583 2937007
SGTC_2531 methyl deoxycholate 70.07 µM -1.65888079963548 0.0414397300771468 no 3160 0.0485699071844031 4509 16667744 Haematoxylin.
SGTC_1789 tunicamycin 25 nM -1.65902762288205 0.0414262161024515 no 3161 0.0485551131149196 4489 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_412 gemfibrozil 100 µM -1.66120638404247 0.0412260969476583 no 3162 0.048336001928673 4526 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1964 st076914 61 µM -1.66626130383852 0.0407648204535389 no 3163 0.0478306902307497 4607 24208661
SGTC_3213 9129884 49.47 µM -1.66798591087179 0.0406084063860641 no 3164 0.0476592618416885 4546 17190742
SGTC_1610 st001799 48.1 µM -1.66925935302606 0.0404932238653909 no 3165 0.047532995977881 4544 621897
SGTC_347 4534-1311 26.2 µM -1.67014862641776 0.040412946703272 no 3166 0.0474449806891891 4594 2862016
SGTC_2148 5546263 113.568 µM -1.69192150082538 0.0384874371804024 no 3167 0.0453304709365235 4617 792097
SGTC_2365 9042475 200 µM -1.70464667248812 0.037397133934639 no 3168 0.04413017059231 4608 6464479
SGTC_2972 9093619 59.92 µM -1.70727975023936 0.0371747098036948 no 3169 0.0438850340261937 4562 25236256
SGTC_1866 st057638 64 µM -1.70904610713687 0.0370261069403825 no 3170 0.0437212045880843 4607 688802
SGTC_914 3820-6779 408 µM -1.71147468142783 0.0368225850956873 no 3171 0.0434967605765287 4515 2893481
SGTC_1968 st069590 43.6 µM -1.72070057974194 0.0360577497717388 no 3172 0.0426525855680629 4565 6384066
SGTC_2512 diallyl trisulfide 49.23 µM -1.72112160056935 0.0360231595274571 no 3173 0.0426143801899145 4629 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2783 7738165 71.43 µM -1.73049648641592 0.0352599515900475 no 3174 0.0417708042235335 4579 17201110
SGTC_867 0518-0118 155 µM -1.73202934599955 0.0351364325543684 no 3175 0.0416341687915173 4578 6848158
SGTC_1565 sinapyl alcohol 95.1 µM -1.73356520970112 0.035013027738385 no 3176 0.0414976289250009 4598 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1091 telmisartan 47.6 µM -1.75361689285773 0.0334342930296623 no 3177 0.0397480872307559 4632 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3252 9135871 49.47 µM -1.75675191632255 0.033192843326743 no 3178 0.0394800520858465 4629 17682838
SGTC_1575 cyproterone acetate 48 µM -1.757082449533 0.0331674706051212 no 3179 0.0394518783660257 4598 9880 An androgen receptor antagonist and liver toxin.
SGTC_256 clotrimazole 625 nM -1.76278871068345 0.0327319540053075 no 3180 0.0389680660824179 4557 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3062 9077494 49.47 µM -1.76990169609019 0.0321956857581624 no 3181 0.0383717591211003 4544 16459633
SGTC_559 1550-0661 158 µM -1.774066182412 0.0318850934607271 no 3182 0.0380261018674982 4641 5830875
SGTC_1667 st014849 34.6 µM -1.78150878297583 0.031336180458249 no 3183 0.0374146856762296 4708 5348460
SGTC_2302 7771753 200 µM -1.78228028434816 0.0312797297336554 no 3184 0.0373517680779289 4589 2203047
SGTC_800 3448-7362 155 µM -1.80302615531168 0.0297930139315607 no 3185 0.0356920535510385 4682 15991913
SGTC_2011 4012611 177 µM -1.80434320833706 0.0297006430387284 no 3186 0.035588760058632 4603 2049887
SGTC_1416 3966-0321 25.3 µM -1.8069622502174 0.0295176638511164 no 3187 0.0353840826631961 4682 582530 YLR208W SEC13
SGTC_205 1486-1330 71.903 µM -1.80699222367125 0.0295155751859818 no 3188 0.0353817458450964 4708 4118834
SGTC_2676 harmalol 100 µM -1.80974084452337 0.0293245615566791 no 3189 0.0351679926667537 4608 5459187 A monoamine oxidase inhibitor
SGTC_269 exalamide 29 µM -1.81008969099042 0.0293003922731745 no 3190 0.0351409396981849 4629 3316 A derivative of salicylamide.
SGTC_2266 7929956 200 µM -1.81381614502575 0.0290432414695689 no 3191 0.0348530180180983 4598 2967153
SGTC_1504 k297-0033 30 µM -1.82013545601695 0.0286114534535797 no 3192 0.0343691896526079 4548 4388117
SGTC_2881 9058953 51.95 µM -1.82633613784058 0.028192974245439 no 3193 0.0338998224823747 4607 17122249
SGTC_909 3448-9333 149 µM -1.83045604601177 0.0279177520552073 no 3194 0.0335908867890779 4573 3344074
SGTC_880 0833-0487 87.2 µM -1.8342214580832 0.0276681722067736 no 3195 0.0333105637103656 4628 76075
SGTC_3155 9099265 49.47 µM -1.8455216709816 0.026930309215327 no 3196 0.0324808445229606 4631 25236499
SGTC_272 doxorubicin 8.13 µM -1.85671549830794 0.0262156605368765 no 3197 0.0316758206744183 4666 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_36 0335-0881 14.2 µM -1.86083289562948 0.0259568133617841 no 3198 0.031383889237984 4566 23828853
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.86718292117097 0.0255618018894425 no 3199 0.030938023889527 4636 442882
SGTC_1291 0993-0025 5.79 µM -1.86764002741153 0.0255335622676911 no 3200 0.0309061315921522 4640 4353356
SGTC_2137 5261020 140 µM -1.86856502674643 0.0254764965388093 no 3201 0.0308416776400329 4628 763655
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.86932770872896 0.0254295249856058 no 3202 0.0307886176898355 4641 688669
SGTC_2235 salicylic acid 500 µM -1.8723417265745 0.0252446087911995 no 3203 0.0305796707292299 4706 338 A COX inhibitor and kinase inhibitor.
SGTC_550 4123-0385 25.7 µM -1.87507981535615 0.0250775994080374 no 3204 0.0303908719749582 4672 5731123
SGTC_2320 7373003 200 µM -1.87540928596397 0.0250575659572541 no 3205 0.0303682193086368 4615 5415828
SGTC_247 mechlorethamine 29.705 µM -1.87696936816521 0.0249628872750299 no 3206 0.0302611461508118 4648 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2095 5432005 200 µM -1.88175912238661 0.0246740776098936 no 3207 0.0299343641506978 4667 783734
SGTC_1812 st052057 4.327 µM -1.88615068023964 0.0244117467687884 no 3208 0.0296373262366511 4676 3645418
SGTC_2024 5144227 134 µM -1.89698290919828 0.0237746757040643 no 3209 0.0289150968969293 4627 3475211
SGTC_1750 st081859 2.357 µM -1.90154760189561 0.0235104315675927 no 3210 0.0286151618477425 4588 5291695
SGTC_2113 5491891 107.031 µM -1.90337006147111 0.0234056240707999 no 3211 0.028496137353131 4653 789979
SGTC_878 0828-0289 13.7 µM -1.91568566422717 0.0227076252071929 no 3212 0.0277025591297828 4636 745350 YLR208W SEC13
SGTC_2853 9015042 58.44 µM -1.91712509572555 0.022627201002541 no 3213 0.0276110205583514 4580 6457456
SGTC_1303 1160-0052 261 µM -1.92216558774156 0.0223474677005358 no 3214 0.0272924626836559 4631 3562476
SGTC_2721 ifenprodil 61.44 µM -1.93973532567034 0.0213950976639075 no 3215 0.0262059320503807 4637 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2728 chlorpromazine 9.18 µM -1.94726927271574 0.0209973569520749 no 3216 0.0257512302588367 4743 2726 A thorazine and dopamine antagonist.
SGTC_2257 7960413 200 µM -1.95150435364183 0.0207765338688388 no 3217 0.025498539409675 4702 2974689 YIL048W NEO1
SGTC_1400 3771-8998 51.5 µM -1.95530715782669 0.0205799289533308 no 3218 0.025273413429557 4663 670767
SGTC_232 clozapine 119 µM -1.96097715150898 0.0202897184483152 no 3219 0.02494084415032 4719 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1105 epirubicin 18.1 µM -1.96803296256345 0.0199334285084896 no 3220 0.0245321225838253 4686 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_374 0880-0231 82.3 µM -1.96805974759948 0.0199320861523739 no 3221 0.0245305817840543 4556 6833587
SGTC_2850 9015429 58.44 µM -1.97605062978899 0.0195350258887195 no 3222 0.0240745216088617 4670 6457570
SGTC_636 0kpi-0074 126 µM -1.9832130145578 0.0191848619853536 no 3223 0.0236718203865816 4701 616434
SGTC_1676 st018489 23.4 µM -1.9846819554708 0.0191137097076603 no 3224 0.0235899338268221 4637 3696235
SGTC_2445 5742597 35.57 µM -1.98512604021817 0.0190922434323965 no 3225 0.0235652251377199 4675 1774255
SGTC_1104 tacrolimus 29.8 µM -1.98517600844519 0.0190898293397257 no 3226 0.023562446289545 4724 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2993 9054257 71.4286 µM -1.9914115583149 0.0187906041795186 no 3227 0.0232178297870031 4618 6470217 YGL055W OLE1
SGTC_2342 7990637 118.86 µM -1.99323684581323 0.0187037728873315 no 3228 0.0231177591003434 4661 2033102 YER133W GLC7
SGTC_2013 4024628 200 µM -1.99914510046026 0.0184250476122035 no 3229 0.0227963282769429 4675 5230760
SGTC_1038 k292-0204 154 µM -2.00090557205596 0.0183426835585368 no 3230 0.0227012834934587 4633 4454212
SGTC_1987 st072290 61.9 µM -2.00147940748831 0.0183159044111234 no 3231 0.022670375387772 4693 54697379
SGTC_2114 5491910 81.25 µM -2.00334050571059 0.018229281714123 no 3232 0.0225703762945115 4690 2849228
SGTC_2355 9061122 103.12 µM -2.00491219159657 0.0181564015050005 no 3233 0.0224862175608959 4689 5302957
SGTC_203 k066-0004 30.888 µM -2.01954583650512 0.0174896693881505 no 3234 0.0217152591179743 4724 6795412
SGTC_3076 9116187 49.47 µM -2.02350561152921 0.0173128904316058 no 3235 0.021510522810235 4698 27241210
SGTC_2425 5628681 7.85 µM -2.02854168509583 0.0170902683358831 no 3236 0.0212524966853074 4700 5714958
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.03072852834498 0.0169943623968453 no 3237 0.0211412703592017 4633 676296 Flavone; oxidizing agent.
SGTC_2773 thioridazine 9.09 µM -2.03279095445417 0.0169043348328841 no 3238 0.0210368237013891 4684 5452 An antipsychotic.
SGTC_951 1171-0579 82.7 µM -2.03331862032852 0.0168813671594165 no 3239 0.0210101715762885 4622 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_746 1095-0025 46.6 µM -2.04271300767484 0.0164769034471413 no 3240 0.0205404282021723 4703 6749286
SGTC_2734 clemastine 41.6 µM -2.04757002096385 0.0162710638232734 no 3241 0.0203010746715278 4754 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_302 1094-0063 18.9 µM -2.04969147935777 0.0161818501415874 no 3242 0.0201972735117515 4707 5440289
SGTC_1663 st014140 55.4 µM -2.0498638603752 0.0161746194486196 no 3243 0.0201888588597917 4733 4207120
SGTC_88 0180-0332 8.668 µM -2.05213077983514 0.0160797885300291 no 3244 0.020078477169357 4733 3101745
SGTC_1007 4101-0031 70 µM -2.06333093205247 0.0156182203803576 no 3245 0.0195405985706555 4697 1146276
SGTC_1028 k015-0029 4.8 µM -2.07124583696405 0.0152989372778069 no 3246 0.0191679140256311 4689 4588309
SGTC_3254 9136651 49.47 µM -2.07188308432462 0.015273476638847 no 3247 0.0191381729304211 4670 16454030
SGTC_717 1532-0246 73.2 µM -2.07582223560157 0.0151168978355855 no 3248 0.0189551975262344 4688 9561992
SGTC_1349 flufenamic acid 69 µM -2.08236776420632 0.0148597670190665 no 3249 0.0186544452784785 4653 3371 A non-steroidal anti-inflammatory.
SGTC_721 1187-1332 279 µM -2.08998683285297 0.0145652088449202 no 3250 0.0183094912592074 4705 25730
SGTC_145 3737-0113 38.366 µM -2.09223757897085 0.0144791607481367 no 3251 0.0182086342162408 4675 6849351
SGTC_147 4466-0538 29.23 µM -2.10578255997723 0.0139705098890542 no 3252 0.0176116222133565 4686 6742687 YHR072W ERG7
SGTC_2325 6158266 200 µM -2.10990880279243 0.0138186517375597 no 3253 0.0174331059438139 4685 3623240
SGTC_1181 1222-0449 220 µM -2.11131509806448 0.0137672221455188 no 3254 0.0173726185844107 4732 658318
SGTC_1166 k206-0078 225 µM -2.11236837203363 0.0137288111037876 no 3255 0.0173274328002479 4699 5404595
SGTC_3028 9087778 49.47 µM -2.11683015484799 0.0135671213624403 no 3256 0.0171371325625856 4680 17217395
SGTC_630 4356-0227 183 µM -2.12346688116855 0.0133296557255092 no 3257 0.0168573739569155 4683 779312
SGTC_2142 5622915 118.518 µM -2.12361523092892 0.013324388970683 no 3258 0.0168511654471547 4719 5322196
SGTC_1049 3226-0134 66 µM -2.12584548774179 0.0132454261277719 no 3259 0.0167580635403075 4709 5702385
SGTC_1900 st060200 72.8 µM -2.12714449155388 0.0131996211078126 no 3260 0.0167040397670484 4705 688945
SGTC_2461 5755302 26.15 µM -2.1300206955382 0.0130986881690148 no 3261 0.0165849524003354 4700 2788904
SGTC_526 4469-0568 170 µM -2.13511035003622 0.0129217139964309 no 3262 0.0163759987057649 4685 2901964
SGTC_1992 st073643 23.3 µM -2.13837608280995 0.0128092522511589 no 3263 0.0162431160150446 4715 3161292
SGTC_2119 5528445 120.635 µM -2.14347540396371 0.0126353406883327 no 3264 0.0160374720120893 4726 791935
SGTC_745 0469-0705 296 µM -2.15453652955146 0.012265113833238 no 3265 0.0155990602213732 4737 3486736
SGTC_2614 arthonioic acid 13.39 µM -2.15806363759994 0.0121490516354429 no 3266 0.0154614421984025 4611 6710684
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.16160527583201 0.0120334703695965 no 3267 0.0153243072290688 4695 115019
SGTC_1290 0986-0249 10.2 µM -2.17979421121741 0.0114547789948278 no 3268 0.0146363596182103 4632 53329
SGTC_397 arbidol 50 µM -2.20014374906078 0.0108361432228027 no 3269 0.0138983488803715 4725 131410 A RNA synthesis inhibitor.
SGTC_1732 st034308 51.822 µM -2.20364022351972 0.0107328290435902 no 3270 0.01377482806223 4655 830119
SGTC_1982 st072467 71.9 µM -2.21013683634654 0.0105431421627031 no 3271 0.0135478335146248 4712 3163533
SGTC_1252 0493-0875 34.8 µM -2.25630076135745 0.009277432326861 no 3272 0.0120259008750727 4711 3960963
SGTC_184 1494-0393 24.714 µM -2.25882243124963 0.00921229591151018 no 3273 0.0119472163119104 4709 3090647
SGTC_2433 5607874 27.82 µM -2.26389069999269 0.00908258887865579 no 3274 0.0117904190447759 4711 2252428
SGTC_175 3793-3120 23.7 µM -2.28113461869611 0.0086531828187199 no 3275 0.0112702410826307 4716 5322297
SGTC_600 1495-0418 41.6 µM -2.28534129996525 0.00855116996719742 no 3276 0.0111464115228042 4735 5377768
SGTC_2566 crystal violet carbinol 226 nM -2.30047170654757 0.00819292528793913 no 3277 0.0107107552187853 4665 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_991 3996-0057 64.7 µM -2.30780922976393 0.00802399120617267 no 3278 0.0105048746756325 4734 715343
SGTC_1885 st057546 99.9 µM -2.31469896886515 0.00786816203709846 no 3279 0.0103147061234622 4741 702008
SGTC_2466 5983409 37.09 µM -2.33273005395486 0.0074728750596319 no 3280 0.00983115889177625 4753 2879657
SGTC_525 k781-2675 26.7 µM -2.33857518273713 0.00734854490780687 no 3281 0.00967871522358371 4717 3651118 YDL195W SEC31
SGTC_1787 fluconazole 80 µM -2.34001775015852 0.00731814239034191 no 3282 0.009641411706568 4432 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2951 9072950 58.06 µM -2.34255539088617 0.00726492990538924 no 3283 0.00957609542450768 4699 16488155
SGTC_2732 terfenadine 20 µM -2.34365477740108 0.00724198268414657 no 3284 0.00954791863520277 4776 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_298 1391-0729 10 µM -2.34606167530772 0.00719196712173646 no 3285 0.00948648383068013 4717 3237558
SGTC_244 nsc-207895 1.295 µM -2.34690823795208 0.00717444803313807 no 3286 0.00946495807884188 4694 42640
SGTC_1488 4013-0813 75.9 µM -2.34724569161403 0.00716747513866915 no 3287 0.00945638947718694 4765 2910057
SGTC_1947 st076332 61.6 µM -2.35359697492695 0.00703734733866364 no 3288 0.00929637872446588 4671 24208416
SGTC_42 0133-0086 60.653 µM -2.35669999825119 0.00697453282809515 no 3289 0.00921906795431921 4685 162923 Model of phenazepam hydroxylation.
SGTC_3159 9100096 49.47 µM -2.37489046378456 0.00661616288556897 no 3290 0.00877707931851145 4698 25236875
SGTC_1904 st060225 78 µM -2.38302052796219 0.00646132655561441 no 3291 0.00858561838793556 4735 66595
SGTC_881 0833-0569 170 µM -2.39791294112845 0.00618599844400953 no 3292 0.00824439184506035 4762 5418700
SGTC_2063 5246145 200 µM -2.40498055054923 0.0060590085302821 no 3293 0.00808666326260187 4737 711240
SGTC_1082 camptothecin 424.86 nM -2.41283716495851 0.00592055835920165 no 3294 0.00791444477753606 4662 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1681 tripelennamine 100 µM -2.41752303421731 0.00583932563990286 no 3295 0.0078132724627508 4693 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2675 theaflavin digallate 100 µM -2.42593048573598 0.00569605237072146 no 3296 0.00763459733615225 4714 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1415 3966-0071 78.1 µM -2.42767383365218 0.00566673722893592 no 3297 0.00759800128443154 4710 2893185
SGTC_250 brefeldin a 552.239 µM -2.45510710989816 0.00522275202428799 no 3298 0.00704213081357048 4770 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1868 st057644 42.7 µM -2.47660102758499 0.00489680065607988 no 3299 0.00663200400953952 4767 688665
SGTC_1026 k007-1105 30.6 µM -2.47796636023089 0.00487672161492474 no 3300 0.00660668012533025 4729 7066794
SGTC_2779 methotrexate 400 µM -2.47808698825382 0.00487495115146819 no 3301 0.00660444685954763 4739 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1016 4226-1401 38 µM -2.48031776624462 0.00484231300419617 no 3302 0.00656326713557474 4767 2901613
SGTC_679 0422-0091 41.4 µM -2.48241512067704 0.00481180475923238 no 3303 0.00652475764443239 4767 627384 YHR062C RPP1
SGTC_2477 5967686 25.23 µM -2.54526617049258 0.00397355059773976 no 3304 0.0054597234487119 4748 776118
SGTC_151 3013-0144 2.285 µM -2.55044136807341 0.00391073449884262 no 3305 0.00537933094153661 4571 906558 YHR107C CDC12
SGTC_2896 9052656 71.43 µM -2.590183291631 0.00345725116463824 no 3306 0.00479624210710267 4448 6469436
SGTC_673 1082-0474 110 µM -2.61615208871972 0.00318703852017177 no 3307 0.00444634688569206 4754 3098046
SGTC_400 oxethazaine 37.5 µM -2.65275724852121 0.00283840506720101 no 3308 0.00399186327083503 4786 4621 A local anesthetic.
SGTC_2249 haloperidol 116.36 µM -2.65387149946929 0.00282835425115623 no 3309 0.00397870617976262 4723 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_74 000s-0487 160.283 µM -2.68228632851668 0.00258265451042212 no 3310 0.00365604229299611 4720 677548
SGTC_60 0986-0278 202 µM -2.69116797462667 0.00250991166997248 no 3311 0.0035601167109563 4752 3110598
SGTC_1867 st057372 64 µM -2.69475025111432 0.00248110000340125 no 3312 0.00352207039777214 4782 688837
SGTC_1310 1188-0297 994 nM -2.70829170963085 0.00237487081092316 no 3313 0.00338152746081606 4731 1588352
SGTC_1931 st074438 57.1 µM -2.72759410008555 0.00223055906276597 no 3314 0.00318990290339923 4776 2787313
SGTC_2019 4016004 108 µM -2.72792472583629 0.00222815794116086 no 3315 0.00318670750152577 4761 45595336
SGTC_1721 st082152 9.2685 µM -2.76303513174909 0.00198611342335854 no 3316 0.00286333011059357 4761 5296051
SGTC_55 0767-0285 6.563 µM -2.76428176870315 0.00197797586465202 no 3317 0.00285241265815765 4763 3116166
SGTC_1459 k035-0031 35.7 µM -2.77186989090645 0.00192909322239032 no 3318 0.00278676545573155 4699 3877128 YMR208W ERG12
SGTC_849 0386-0493 241 µM -2.80985435005941 0.00170049915115906 no 3319 0.00247819622417413 4788 726119
SGTC_1316 1272-0050 65.9 µM -2.82534009795426 0.00161460052184002 no 3320 0.0023615227599401 4788 7340392
SGTC_431 k089-0097 107 µM -2.95222566404161 0.00104637592381172 no 3321 0.00157746135855229 4600 5499420
SGTC_2247 cerulenin 830 nM -2.95281626301824 0.00104422606753392 no 3322 0.00157444663300945 4788 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2666 tannic acid 100 µM -2.98299543330044 0.000939614579821827 yes 3323 0.00142721126661815 4789 16134267 A thiamine antagonist.
SGTC_1313 1220-0047 237 µM -2.99091914552271 0.000913791396380537 yes 3324 0.00139069563777912 4805 3528706
SGTC_796 1234-0020 70.7 µM -3.06799245731872 0.000694534961624432 yes 3325 0.00107751028677515 4774 46495034
SGTC_3054 9094397 49.47 µM -3.08453509375236 0.000654306183444413 yes 3326 0.00101935278301995 4780 2598354
SGTC_1554 st069299 38.7 µM -3.09961727117262 0.00061951415285631 yes 3327 0.00096885426102641 4789 24207999
SGTC_911 3456-4043 236 µM -3.16141304986467 0.000494063420833186 yes 3328 0.000785028426242572 4777 914281
SGTC_3077 9117319 49.47 µM -3.22439130091781 0.000390759288047472 yes 3329 0.000631203860005868 4777 17154678
SGTC_631 k072-0230 41.5 µM -3.26265497455148 0.000338191477898257 yes 3330 0.000551869031764278 4800 5773147
SGTC_613 3914-0030 117 µM -3.2864878084745 0.000308855076078851 yes 3331 0.00050722582533567 4726 1145395
SGTC_1265 0819-1001 68.8 µM -3.28741297176993 0.000307765496795404 yes 3332 0.000505562180897786 4777 3106768
SGTC_2144 5628481 200 µM -3.29205390774625 0.000302353563169239 yes 3333 0.000497292726169126 4802 2818399
SGTC_2241 6772625 37.8075 µM -3.30084524624662 0.000292343728313255 yes 3334 0.000481970176352322 4724 2285411
SGTC_1258 0671-0043 57.1 µM -3.49171043582465 0.000138053569805587 yes 3335 0.000239969119948584 4796 4298767
SGTC_793 0488-0545 106 µM -3.52917917536974 0.000118628543333257 yes 3336 0.0002084253980403 4800 292548
SGTC_1191 1487-1166 10.6 µM -3.53149428606465 0.000117516689187691 yes 3337 0.000206609394749259 4797 3955771
SGTC_1550 gossypolone 36.6 µM -3.57358981709199 9.89289233397779e-05 yes 3338 0.000176060191973436 4804 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1638 st008370 60.6 µM -3.66773527860814 6.68716835141903e-05 yes 3339 0.000122354171263469 4787 24207134
SGTC_288 1315-0019 35.1 µM -3.68255529980236 6.28217496009369e-05 yes 3340 0.000115453878798763 4805 6811474
SGTC_750 4073-0104 132 µM -3.74468355256953 4.82284691685076e-05 yes 3341 9.03106436620478e-05 4727 22330957
SGTC_3052 9092717 49.47 µM -3.78055296614633 4.13274040392723e-05 yes 3342 7.82402118745123e-05 4801 25237534
SGTC_2238 6671620 73.2395 µM -3.78502633876743 4.05353591789056e-05 yes 3343 7.68461500089326e-05 4774 729941
SGTC_1045 1348-1485 165 µM -3.80355243087874 3.74053922981545e-05 yes 3344 7.13178935905165e-05 4801 6810614
SGTC_2021 4019055 173 µM -3.84860138832907 3.07207385503032e-05 yes 3345 5.93970643568075e-05 4765 44827708 YER133W GLC7
SGTC_3283 9109332 35.8195 µM -3.88583369008937 2.60664356311879e-05 yes 3346 5.09896532929175e-05 4788 17027281
SGTC_1001 4048-4355 44.4 µM -3.89041958677586 2.55417515944894e-05 yes 3347 5.00355178134567e-05 4805 21824233
SGTC_3351 9150312 21.596 µM -3.90518572130102 2.39194955014053e-05 yes 3348 4.70765240416747e-05 4803 4904905
SGTC_398 bronopol 33.3 µM -4.02258839521264 1.40830638244698e-05 yes 3349 2.87810200060233e-05 4802 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_178 4092-0806 87.505 µM -4.19436568712708 6.32371931443926e-06 yes 3350 1.36818115625274e-05 4795 2169044
SGTC_913 3487-1245 167 µM -4.57515162228998 9.6135171360407e-07 yes 3351 2.37937610046112e-06 4804 4016153
SGTC_1629 st005085 44.9 µM -4.57541557655145 9.60047141187271e-07 yes 3352 2.37637798883598e-06 4809 24207091
SGTC_1107 amlodipine 47 µM -4.76716593595729 3.51199200584646e-07 yes 3353 9.34177131830478e-07 4708 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3191 9110352 49.47 µM -4.84744241975797 2.27915758635915e-07 yes 3354 6.25316573506326e-07 4807 17122424
SGTC_1633 st005664 67.9 µM -5.00090963545339 9.78736531480909e-08 yes 3355 2.8530227004356e-07 4810 2063822
SGTC_1926 methyl fluorone black 53.6 µM -6.79303477731404 8.11190992350298e-13 yes 3356 5.48994489091099e-12 4805 72721 Reacts with homocysteine.