SGTCid condition conc unit NAB3|YPL190C.score NAB3|YPL190C.strain.pval NAB3|YPL190C.strain.significant NAB3|YPL190C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_429 1112-0049 25.5 µM 7.18371835002425 1.88135900622745e-14 yes 1 3.39202747780922e-13 2 2836170 SGTC_2998 9066762 71.4286 µM 7.04272865370728 5.83608013351839e-14 yes 2 9.42555612005528e-13 2 4945196 SGTC_2022 5136654 200 µM 4.15651630615924 5.91594556881784e-06 yes 3 1.61568559302175e-05 3 1713771 SGTC_2990 9074105 71.4286 µM 3.86593861778641 2.30444509503501e-05 yes 4 5.53313852272123e-05 5 6502001 SGTC_425 3825-7017 13.1 µM 3.83092964203562 2.69829968659292e-05 yes 5 6.38300046019124e-05 9 3397440 SGTC_1747 st037496 66.6 µM 3.81625118790626 2.88172822381948e-05 yes 6 6.77472860075931e-05 8 723305 SGTC_2087 5276107 200 µM 3.7948732078666 3.17011788956785e-05 yes 7 7.38594633283521e-05 7 144405 SGTC_1716 st033144 30.6155 µM 3.74428826473324 3.9650991425642e-05 yes 8 9.04529303098698e-05 8 674617 SGTC_2992 9074591 71.4286 µM 3.48971415238603 0.00011736017572417 yes 9 0.000241768729299444 6 17741321 SGTC_593 1203-0218 61.7 µM 3.41041262782748 0.000162283960359604 yes 10 0.000324323316306724 7 3666956 SGTC_631 k072-0230 41.5 µM 3.19485429526656 0.000378811174489693 yes 11 0.000699507256192258 12 5773147 SGTC_2894 9048625 32.47 µM 3.06738512581525 0.00061124896036372 yes 12 0.00107970220949145 20 4092861 SGTC_1911 st060208 74.3 µM 3.06411550935754 0.0006186593922585 yes 13 0.00109157299840007 15 688783 SGTC_1853 st056710 91.2 µM 3.05399362607458 0.000642129366548875 yes 14 0.00112908439293912 15 269167 SGTC_2520 obtusaquinone 4.71 µM 2.97907695788047 0.000843093344453829 yes 15 0.0014455907690671 17 5967872 SGTC_829 1635-0120 117 µM 2.95977243775209 0.000903520076341727 yes 16 0.00153933178984445 68 285054 SGTC_623 k072-0108 16.9 µM 2.94356912411139 0.000957285001129008 yes 17 0.00162225679772628 30 5382803 SGTC_431 k089-0097 107 µM 2.9200820457448 0.00104044683529085 no 18 0.00174969621630915 30 5499420 SGTC_2612 dictamnine 15.46 µM 2.85357672262952 0.00131316580737928 no 19 0.00216150439230561 51 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3035 9091303 49.47 µM 2.83282239538098 0.00141079523448078 no 20 0.00230695066772353 7 25237002 SGTC_1914 st062367 72.6 µM 2.80878487013269 0.00153212542934113 no 21 0.0024864432383679 18 978205 SGTC_2127 5253358 187.912 µM 2.79127162978458 0.001626435519343 no 22 0.00262506959668194 20 20612 SGTC_103 0844-0104 51.839 µM 2.78297171318251 0.00167295292292939 no 23 0.00269317510075876 74 5375804 SGTC_2922 7999257 32.47 µM 2.77047579504748 0.00174527521880181 no 24 0.00279872301794238 22 2988377 SGTC_2797 7859098 81.82 µM 2.74586515631496 0.00189609358915211 no 25 0.00301757817308058 22 972681 SGTC_3007 9078383 71.4286 µM 2.74487369268057 0.00190241049947066 no 26 0.00302670955794522 22 6496995 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.72342218434627 0.00204385274985909 no 27 0.00323047170879316 24 6708739 YPR165W RHO1 SGTC_326 k292-0812 17.5 µM 2.71627591026859 0.00209305046655237 no 28 0.00330104360904281 15 3579357 SGTC_2447 5741742 33.78 µM 2.70757470908055 0.00215440206128726 no 29 0.00338884070574054 27 1776504 SGTC_3270 9137563 49.47 µM 2.67739998991172 0.00238000155246224 no 30 0.00370979997017048 15 17015724 SGTC_2335 9018011 154.17 µM 2.67626743180531 0.00238887092599273 no 31 0.00372236071677921 31 6458208 SGTC_3085 9117376 49.47 µM 2.66452261581179 0.00248262700067416 no 32 0.00385488410477542 25 16480349 SGTC_2987 9018338 71.43 µM 2.65507075384842 0.00256048176926786 no 33 0.00396458877184584 29 5055682 SGTC_1468 k284-1086 134 µM 2.64573253340996 0.00263956079552848 no 34 0.0040757120170202 38 15996457 SGTC_1724 st037281 8.293 µM 2.62574768859594 0.002816257366335 no 35 0.00432294396853162 39 574124 YDL195W SEC31 SGTC_1557 sumaresinolic acid 42.3 µM 2.59457787897087 0.00311321176245279 no 36 0.0047353577406647 11 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_527 4476-4215 268 µM 2.56804471153187 0.00338789011185786 no 37 0.00511369817338662 17 4418754 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.5539229434106 0.00354279493522266 no 38 0.00532584132632398 37 16725076 SGTC_2275 7947463 200 µM 2.49128420785726 0.00430930932462311 no 39 0.00636411296090192 34 1225414 SGTC_605 1315-0399 119 µM 2.47564154697466 0.00452250987186267 no 40 0.00664985154547928 32 24020461 SGTC_1293 1000-1278 195 µM 2.44405766733891 0.00498189565523112 no 41 0.007261552464076 32 678847 SGTC_526 4469-0568 170 µM 2.44091333182677 0.00502983091839048 no 42 0.00732508509632049 33 2901964 SGTC_426 0988-0037 14.6 µM 2.43893268903748 0.00506023618193278 no 43 0.00736535590435445 41 5383008 SGTC_3097 9117246 49.47 µM 2.42615540645407 0.00526034637850211 no 44 0.00762986713719248 19 16423892 SGTC_1975 st070967 30.8 µM 2.41221577319799 0.00548666208456277 no 45 0.00792794736457583 54 261391 SGTC_2399 5884133 200 µM 2.40851964382428 0.005548103381098 no 46 0.00800868213925248 45 722445 SGTC_763 3453-1109 128 µM 2.40180448296762 0.00566129604351505 no 47 0.00815721277596313 27 1560353 SGTC_1392 3455-1037 33.9 µM 2.40180075999722 0.00566135936350749 no 48 0.00815729579007989 31 981132 SGTC_3137 9097352 49.47 µM 2.3980678271341 0.00572516608230322 no 49 0.00824090648300199 42 44120435 SGTC_2800 7887935 81.82 µM 2.38039097637919 0.00603606311584162 no 50 0.00864713887718703 37 2961002 SGTC_1963 st076565 50.3 µM 2.37716349546459 0.00609441585062559 no 51 0.00872317664250949 29 4914280 SGTC_2724 maprotiline 69.64 µM 2.33591197198808 0.00688547653578855 no 52 0.00974791493816621 31 4011 A tricyclic antidepressant. SGTC_384 k007-0144 5.16 µM 2.3353403923826 0.00689704651779113 no 53 0.00976282282605963 55 6824886 SGTC_1301 naphtanilide LB 4.81 µM 2.32325120208108 0.00714581171754322 no 54 0.0100828308049833 51 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1874 staurosporine 7.6 µM 2.30603447772915 0.0075137443219705 no 55 0.01055435295674 33 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_967 1306-0166 352 µM 2.30517661746599 0.00753250612792288 no 56 0.0105783419317774 26 4437607 SGTC_152 4469-0003 551.229 µM 2.30335659313664 0.00757244760297699 no 57 0.0106293939416863 61 697280 SGTC_761 k216-0224 480 µM 2.29984954983285 0.00764993793494568 no 58 0.0107283725666759 37 1340404 SGTC_2837 9008476 45.46 µM 2.28391804388829 0.00801081034923523 no 59 0.011188173988723 31 2992805 SGTC_3142 9086498 49.47 µM 2.28346540268664 0.00802127840738813 no 60 0.0112014842774091 88 25236367 SGTC_2278 7948257 134.34 µM 2.26791642302876 0.00838825180425918 no 61 0.0116671505829319 22 1247028 SGTC_842 0271-0008 11.1 µM 2.24856981640929 0.00886537206601178 no 62 0.0122699392833828 49 1221709 SGTC_1043 0916-0009 19.3 µM 2.23781638205768 0.00914072171846278 no 63 0.0126165158306864 43 3101130 SGTC_648 0375-0473 33.3 µM 2.2255919923272 0.00946280390828098 no 64 0.0130207615279927 39 1713139 SGTC_2085 5307070 144.047 µM 2.21996057083255 0.00961448736021248 no 65 0.013210722121863 49 2840351 SGTC_1558 st069300 45.6 µM 2.21176779718433 0.00983895497118742 no 66 0.013491356630979 37 24208000 SGTC_1979 st071809 45.3 µM 2.2049928944349 0.0100280192003807 no 67 0.013727296574668 35 4976333 SGTC_288 1315-0019 35.1 µM 2.1919599081998 0.0104006574618645 no 68 0.0141912008269781 61 6811474 SGTC_2515 chrysin 20.77 µM 2.18115534695227 0.0107186749547141 no 69 0.0145859641449441 29 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2160 5660466 132.927 µM 2.17716684192994 0.0108381929635519 no 70 0.0147340606573971 55 2859134 SGTC_2277 7947813 106.88 µM 2.16944119937353 0.0110729993875108 no 71 0.0150246019821713 48 1246798 SGTC_1648 st011736 69.8 µM 2.16059899779171 0.0113471600085751 no 72 0.0153631644564802 37 2855514 SGTC_3352 9151559 45.5865 µM 2.15280429813407 0.0115937146446759 no 73 0.0156670311089038 39 17159339 SGTC_3223 9129970 49.47 µM 2.14451727543625 0.0118609306977705 no 74 0.01599573136748 40 17248386 SGTC_138 0850-0259 40.9225 µM 2.12684626137836 0.0124486324667188 no 75 0.0167164295528011 96 6813004 SGTC_102 gallobenzophenone 83.616 µM 2.12164857129461 0.0126262275101334 no 76 0.0169336301785231 42 70837 SGTC_1287 0971-0001 34.6 µM 2.10875004288133 0.0130764462923267 no 77 0.0174830814007108 57 4665869 SGTC_489 paxilline 115 µM 2.09873476843885 0.0134355329416817 no 78 0.0179201439771583 44 105008 A toxic potassium channel blocker. SGTC_1947 st076332 61.6 µM 2.09777172717976 0.0134705062516832 no 79 0.0179626575976831 37 24208416 SGTC_1323 1348-1351 11.2 µM 2.08369432102557 0.013990775263164 no 80 0.0185939905644683 42 6989654 SGTC_769 0302-0231 76 µM 2.0787084168525 0.014179151930303 no 81 0.0188220794480183 80 571869 YER009W NTF2 SGTC_349 k015-0014 24 µM 2.07866053261377 0.0141809716278467 no 82 0.0188242814860277 50 2196908 SGTC_2292 7671323 168.05 µM 2.07635221401505 0.0142689313374595 no 83 0.0189306937141811 82 937504 SGTC_1173 0443-0020 122 µM 2.07499216884655 0.0143209762735138 no 84 0.0189936302838759 51 5331295 SGTC_492 tmb-8 126 µM 2.06740739962407 0.0146142310784895 no 85 0.0193478907934952 31 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_214 4373-3496 70 µM 2.06738249949724 0.0146152022547685 no 86 0.0193490629830628 79 3779166 SGTC_1637 st007924 17.4 µM 2.06064577010478 0.0148800022611355 no 87 0.0196684233972714 39 683336 SGTC_1650 st011916 45.8 µM 2.05163209264155 0.0152407468369245 no 88 0.0201027154158331 35 242528 SGTC_1084 voriconazole 435 nM 2.05128879889929 0.0152546333409705 no 89 0.0201194153198912 59 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_617 3770-0098 35 µM 2.050650692948 0.0152804741086101 no 90 0.020150487951192 57 5962639 SGTC_1369 1866-0067 208 µM 2.04426071432908 0.0155413228896306 no 91 0.020463899026874 45 3531355 SGTC_444 curcumin 90.4 µM 2.02260889428175 0.0164537871673166 no 92 0.0215567432370065 68 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_319 1348-1596 45.5 µM 2.02220112311765 0.0164714026488482 no 93 0.0215777891550334 49 5380505 SGTC_3171 9103192 49.47 µM 2.02070551639083 0.0165361502752764 no 94 0.0216551292282835 27 13018434 SGTC_878 0828-0289 13.7 µM 2.01418451513157 0.0168210083459636 no 95 0.0219950824146854 65 745350 YLR208W SEC13 SGTC_2445 5742597 35.57 µM 2.01206459435646 0.0169145126435065 no 96 0.0221065641533501 55 1774255 SGTC_234 nsc-17383 10.7 µM 2.00841722956686 0.0170764288269872 no 97 0.0222994867588637 52 408974 SGTC_108 0509-0257 621.132 µM 2.00425387310215 0.0172628686122117 no 98 0.0225214361415494 66 536624 SGTC_2961 9083290 32.55 µM 1.99916423254256 0.0174931482402868 no 99 0.0227952935698297 39 17741490 SGTC_3036 9090181 49.47 µM 1.9984120016616 0.0175274042212301 no 100 0.0228360057725343 34 25236586 SGTC_1464 k208-0027 110 µM 1.9960476887323 0.0176354462053121 no 101 0.0229643661013948 53 X1464 SGTC_491 tetrandrine 80.3 µM 1.99049106146734 0.0178916070649094 no 102 0.0232684338357687 46 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1058 3448-5425 97.3 µM 1.98249314856269 0.0182658782486934 no 103 0.0237120367287796 66 7279705 SGTC_1859 st055998 20 µM 1.97846448179227 0.0184569171739781 no 104 0.0239381658227242 55 676301 SGTC_105 0111-0055 734.78 µM 1.97639351628338 0.0185557825582845 no 105 0.0240551126625025 35 5179370 SGTC_2481 5478948 45.16 µM 1.96464756290237 0.0191250909070255 no 106 0.024727521475572 55 77792 SGTC_2588 indole-3-carbinol 100 µM 1.96122862558819 0.0192935662521959 no 107 0.0249261795107584 52 3712 Induces cell cycle arrest. SGTC_1313 1220-0047 237 µM 1.96104866241192 0.0193024691498584 no 108 0.0249366732764148 66 3528706 SGTC_1181 1222-0449 220 µM 1.9601245463471 0.0193482407958654 no 109 0.0249906174304227 50 658318 SGTC_1649 st011737 51.3 µM 1.96003908726535 0.0193524782554887 no 110 0.0249956109390218 40 1761035 SGTC_292 k038-0015 474 µM 1.9584921265688 0.0194293202179087 no 111 0.0250861470090033 41 46368540 SGTC_1077 5-fluorocytosine 377 nM 1.95586460553053 0.0195604307323963 no 112 0.0252405529033128 75 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1133 3473-0247 50 µM 1.95304404883345 0.0197020089746285 no 113 0.0254071879543155 110 711311 SGTC_2525 harmine 47.85 µM 1.95022383189634 0.0198444390274473 no 114 0.0255747232363494 43 5280953 A monoamine oxidase inhibitor SGTC_3356 9151811 4.48 µM 1.94793006408003 0.019960925192545 no 115 0.0257116659493218 57 1859254 YPR165W RHO1 SGTC_2177 5811945 192 µM 1.92696214549687 0.021052898340879 no 116 0.0269921738393413 55 5343475 SGTC_3259 9138485 49.47 µM 1.92498987354438 0.0211581636295521 no 117 0.0271153125616983 47 17646153 SGTC_297 0986-0032 24 µM 1.92028475031837 0.0214110876701404 no 118 0.0274109707682789 56 2847425 SGTC_339 3091-4833 71.4 µM 1.91404094646519 0.021750666151081 no 119 0.027807462023814 89 3240077 SGTC_2678 equilin 100 µM 1.91258142498382 0.0218306971240364 no 120 0.027900829752173 36 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1733 st037357 54.9 µM 1.91234905516145 0.0218434617446052 no 121 0.0279157188609328 59 1272339 YGL099W LSG1 SGTC_2193 5925765 200 µM 1.90482255577661 0.0222603316270864 no 122 0.0284015704182319 43 877370 SGTC_2117 5521686 200 µM 1.8983141410041 0.0226262057351115 no 123 0.0288273561280526 58 803312 SGTC_604 1000-0114 314 µM 1.89463020256426 0.0228355380038344 no 124 0.0290707052852715 46 1572745 SGTC_1883 5-benzylidenerhodanine 20 µM 1.87432615380383 0.0240187691191865 no 125 0.0304427424259891 64 1273210 SGTC_3102 9121669 49.47 µM 1.87102128330053 0.0242161552238177 no 126 0.0306710655300934 49 41905072 SGTC_2859 9028643 45.46 µM 1.8634935676529 0.0246708443492167 no 127 0.0311964283447424 40 17151580 SGTC_852 0418-0143 439 µM 1.8621267481923 0.024754166623953 no 128 0.0312926132634367 64 5369229 SGTC_1500 4488-1866 171 µM 1.86055845232907 0.0248500617317277 no 129 0.0314032783556314 52 2900003 SGTC_960 1222-0186 7.7 µM 1.85710208006211 0.0250625055924369 no 130 0.031648316171702 68 3126296 SGTC_75 0159-0059 199.013 µM 1.85084045416787 0.025451250201986 no 131 0.032096254640526 79 5377270 SGTC_2019 4016004 108 µM 1.84777997593356 0.0256430856802457 no 132 0.0323170894037055 75 45595336 SGTC_60 0986-0278 202 µM 1.84596780922633 0.0257572445925095 no 133 0.0324484398210266 49 3110598 SGTC_2600 tangeritin 87.95 µM 1.84488053308474 0.0258259423758558 no 134 0.0325274595294051 70 68077 A bioactive flavone. SGTC_3228 9131799 49.47 µM 1.84463425880754 0.0258415240971592 no 135 0.0325453799774678 64 17015818 SGTC_741 4582-0002 126 µM 1.84378492335782 0.0258953217308379 no 136 0.0326072453894418 51 2912688 SGTC_1651 st011928 86.1 µM 1.83636627220142 0.0263692211521744 no 137 0.0331517521563479 66 720198 SGTC_1235 benzylparaben 21.5 µM 1.8306042671582 0.0267422772001386 no 138 0.0335798155958193 63 7180 SGTC_477 mead ethanolamide 10 µM 1.83036300578504 0.0267579931119551 no 139 0.033597837847205 15 16061185 SGTC_3245 9134821 49.47 µM 1.82435365788963 0.0271519411679691 no 140 0.0340493116138501 69 17014901 SGTC_350 k064-0020 19.8 µM 1.82425114140516 0.0271587034837455 no 141 0.0340570565982131 66 2790705 SGTC_1959 st077091 55.8 µM 1.82321999720984 0.0272267992403829 no 142 0.034135038766619 98 821356 YKL052C ASK1 SGTC_2041 5107442 45.335 µM 1.81842089036162 0.0275456043823848 no 143 0.0344999139204509 98 793005 SGTC_2884 9058502 51.95 µM 1.81740218391803 0.027613676032713 no 144 0.034577776797799 50 6471554 SGTC_1655 st012546 55.1 µM 1.80700574062361 0.0283164345756397 no 145 0.0353806920653756 53 720985 YLR208W SEC13 SGTC_1234 0326-0494 15.5 µM 1.80695077901781 0.0283201889506645 no 146 0.0353849770249442 73 1547813 SGTC_263 alizarin 107.927 µM 1.80446677282152 0.0284903020127695 no 147 0.0355790817617448 97 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_79 0052-0007 94.094 µM 1.80372945971837 0.0285409589934083 no 148 0.0356368644458563 59 2801472 SGTC_2673 kobusone 100 µM 1.80254712053304 0.0286223478141538 no 149 0.0357296840498018 41 6710676 An epoxy ketone and protein crosslinker. SGTC_490 phenamil 164 µM 1.80175311979573 0.0286771128050238 no 150 0.0357921282516699 58 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2630 antimycin a 100 µM 1.79275033084203 0.0293041840804181 no 151 0.0365064273701269 75 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1555 citronellol 128 µM 1.79224234149302 0.029339903840763 no 152 0.0365470774342662 53 8842 A terpine precursor. SGTC_1527 coumarin 137 µM 1.79159011351893 0.0293858188847779 no 153 0.036599323979938 69 323 A hepatotoxic, DNA x-linker. SGTC_1993 st073995 70.8 µM 1.78527327215607 0.0298336016722825 no 154 0.0371085010018852 70 3098394 SGTC_3050 9093513 49.47 µM 1.77421342443232 0.0306312288112275 no 155 0.0380139272521197 86 25236664 SGTC_782 0083-0095 30.5 µM 1.77038032000546 0.0309117574368481 no 156 0.0383319029585718 62 3591729 An indicator and reagent. SGTC_26 0302-0163 425.158 µM 1.76922155206812 0.030996980126551 no 157 0.0384284544548456 84 3100915 SGTC_3005 9076496 71.4286 µM 1.76908317760763 0.0310071699905318 no 158 0.0384399974054762 49 21368410 SGTC_2079 5212404 121 µM 1.7680229341545 0.0310853380995983 no 159 0.0385285348393506 59 758462 SGTC_1795 st049545 62.3 µM 1.76440434761979 0.0313533527780174 no 160 0.0388319633639877 39 5291882 SGTC_439 amiodarone 34.4 µM 1.76430033708257 0.0313610845975831 no 161 0.0388407136298767 66 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2723 salbutamol 83.58 µM 1.75204210044059 0.032283428047827 no 162 0.0398832844779903 47 9884233 β2-adrenoceptor agonist SGTC_2830 7992007 71.43 µM 1.74933252743926 0.0324902963609718 no 163 0.0401167782490257 72 1952075 SGTC_3222 9128301 49.47 µM 1.74588579772014 0.0327550235337225 no 164 0.0404153991096195 85 4911358 SGTC_2688 kanamycin b 96.69 µM 1.74568891124816 0.0327701990003781 no 165 0.0404325114866536 109 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2131 toluylene red 5.2905 µM 1.74080097823472 0.0331488095261972 no 166 0.0408592352263852 74 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2560 caryophyllene 100 µM 1.73987458220311 0.0332209711613579 no 167 0.0409405213700872 73 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2321 7390090 138.78 µM 1.73829524721084 0.0333442917921685 no 168 0.0410794017037398 63 649046 SGTC_3109 9122853 49.47 µM 1.7348122821706 0.033617587950072 no 169 0.0413870300018445 67 1234709 SGTC_1888 azatryptophan 97.5 µM 1.72848794544717 0.0341185488550093 no 170 0.0419503901855433 61 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1178 0988-0033 191 µM 1.72133536474261 0.0346924956457036 no 171 0.0425949928331775 67 5392207 SGTC_2309 7664088 163.95 µM 1.72094013133124 0.034724440273518 no 172 0.0426308441540558 76 704922 SGTC_130 0136-0219 337.655 µM 1.71994543755103 0.0348049430163122 no 173 0.042721180040184 85 234244 SGTC_2069 5228469 200 µM 1.71566701917054 0.0351529535892174 no 174 0.043111502227201 75 2835210 SGTC_2938 9059746 27.26 µM 1.71553555361955 0.0351636921683589 no 175 0.0431235413602201 79 6471769 SGTC_2913 7966556 36.57 µM 1.71049872470756 0.0355771496521574 no 176 0.0435868445285427 71 2976516 SGTC_420 mitomycin C 81.9 mM 1.70728123311926 0.0358433433532281 no 177 0.0438848962818363 89 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1101 ebselen 5.29 µM 1.70646226398148 0.0359113592950458 no 178 0.0439610232315432 94 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2015 5119600 184 µM 1.69842271141935 0.0365846789280287 no 179 0.0447140042926969 94 2828786 SGTC_2596 sinensetin 100 µM 1.69763064513954 0.0366515704308456 no 180 0.0447887475713757 74 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2931 9014674 55.67 µM 1.69370092276757 0.0369849239627448 no 181 0.0451610645211758 62 2996810 SGTC_827 3253-0474 693 µM 1.68985686838194 0.0373134043396557 no 182 0.0455276704895869 89 5402065 SGTC_1645 Cervolide 78 µM 1.68457071566321 0.0377690024776865 no 183 0.0460357126376827 78 23173 A fragrance. SGTC_2619 obliquin 87.91 µM 1.68426649832816 0.037795359651179 no 184 0.0460650884262224 91 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1355 1499-0035 1.68 µM 1.68221164916507 0.0379737837094898 no 185 0.0462639030047005 70 1548538 SGTC_360 0957-0399 1.01 µM 1.68105908903045 0.0380741617980426 no 186 0.046375718903903 90 6752301 YPR165W RHO1 SGTC_1545 lovastatin 49.4 µM 1.67943070498208 0.0382163488640083 no 187 0.0465340666646881 96 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_402 epigallocatechin gallate 10 µM 1.67485754856239 0.0386179841835864 no 188 0.046981092219968 82 65064 An antioxidant. SGTC_3167 9103034 49.47 µM 1.67313895869873 0.0387698048623013 no 189 0.0471499718138651 74 5127859 SGTC_3339 9145883 14.936 µM 1.66515875706679 0.0394811604861973 no 190 0.0479405433983024 54 2030670 SGTC_358 0075-0058 9.45 µM 1.66409182580358 0.039577066388123 no 191 0.0480470401728728 83 1069125 SGTC_1247 0448-0043 5.84 µM 1.6593309501319 0.0400073306437191 no 192 0.0485245609430214 88 3089013 YGL099W LSG1 SGTC_2100 5377183 190 µM 1.65886229168078 0.0400498903893407 no 193 0.0485717723217367 78 2844202 SGTC_2563 tomatine 8.54 µM 1.65862417016575 0.0400715287373513 no 194 0.0485957741025609 84 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1395 3486-0190 4.35 µM 1.65602198467463 0.0403086116563041 no 195 0.0488586833780571 77 6748079 SGTC_1819 st053448 58.6 µM 1.64900597609355 0.0409535147082942 no 196 0.0495732052054766 93 2857616 SGTC_2324 6149169 200 µM 1.64701231805275 0.0411382886030443 no 197 0.0497777569797324 72 2888231 SGTC_1757 st041620 31.8375 µM 1.64316851604013 0.0414964432052063 no 198 0.0501740359922852 60 5289815 SGTC_812 4251-0442 148 µM 1.64241297898284 0.0415671382687531 no 199 0.0502522234789504 82 5723007 SGTC_505 gw-5074 63.9 µM 1.64213412136033 0.0415932554179377 no 200 0.0502811058555678 83 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2476 5806916 10.51 µM 1.64082414175758 0.0417161229922278 no 201 0.0504169626792212 68 2870194 SGTC_808 0711-0032 135 µM 1.63831637234247 0.0419521554539383 no 202 0.0506778570336398 92 4252555 SGTC_2351 9026858 72.31 µM 1.63621362556066 0.0421508993057799 no 203 0.0508974428674292 95 1409300 SGTC_2924 9010168 62.78 µM 1.63281609083765 0.0424736312674287 no 204 0.0512538409181064 72 2993929 SGTC_2037 5169046 200 µM 1.62905874065583 0.0428328662013285 no 205 0.0516502922404847 77 5718022 SGTC_1321 1326-2144 215 µM 1.62886965486506 0.0428510091268933 no 206 0.0516703076033507 86 3513030 SGTC_2298 7976326 193.81 µM 1.62806891929327 0.0429279091661734 no 207 0.0517551364935763 45 2235818 SGTC_107 0358-0022 2.6945 µM 1.62504049680132 0.0432197579921996 no 208 0.0520769650981021 66 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1905 st060207 84.5 µM 1.62021684547617 0.0436879197495736 no 209 0.0525928520233138 97 1948547 SGTC_946 3434-1334 87.4 µM 1.61449682742338 0.044248372746769 no 210 0.0532098522195007 95 4047976 SGTC_2651 TUB2.036 5 µM 1.60244442975453 0.045448248373593 no 211 0.0545286833121298 110 15992207 YFL037W TUB2 SGTC_2761 levamisole 97.89 µM 1.5980661021528 0.045890558632857 no 212 0.0550141333431622 67 26879 An alkaline phosphatase inhibitor. SGTC_1174 0739-0097 51.1 µM 1.59770008936361 0.0459276903400535 no 213 0.0550548694382873 85 728447 SGTC_1821 st053465 65.6 µM 1.59755946038561 0.0459419634562183 no 214 0.0550705273460832 68 675086 SGTC_3099 9120367 49.47 µM 1.59650318334348 0.0460492840794528 no 215 0.0551882478021741 80 24824940 SGTC_1071 trifluoperazine 6.31 µM 1.59377643163453 0.0463272606133013 no 216 0.0554930590642196 81 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1233 0325-0408 14.2 µM 1.59090482794152 0.0466214588145717 no 217 0.0558154979395778 82 12874 SGTC_3244 9134489 49.47 µM 1.58922980637926 0.0467937572822325 no 218 0.0560042597439853 95 16584271 SGTC_97 0535-0701 19.132 µM 1.58761537537269 0.0469603062507272 no 219 0.0561866696388374 82 2832013 YGL099W LSG1 SGTC_3161 9100388 49.47 µM 1.58634653814829 0.0470915361958277 no 220 0.0563303603971748 85 25236368 SGTC_502 l-744,832 89.3 µM 1.58423721777476 0.0473103439078573 no 221 0.0565698733875351 71 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1472 k841-0093 193 µM 1.58286707746224 0.0474529096908368 no 222 0.0567258820156398 72 X1472 SGTC_3239 9133757 49.47 µM 1.57888280837445 0.0478694371932466 no 223 0.0571814699846711 68 17036923 SGTC_1015 4130-4525 82 µM 1.57692301346404 0.0480753913470101 no 224 0.0574066202479895 91 1363237 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.5762494392806 0.0481463405441366 no 225 0.0574841644068805 89 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_773 4358-1457 44.6 µM 1.5726796960183 0.0485237499238394 no 226 0.0578965017760714 108 1186886 SGTC_346 4513-0042 7.16 µM 1.56982186005375 0.0488275950974285 no 227 0.0582282802252979 95 2827372 SGTC_694 1315-0438 43.2 µM 1.56769079717488 0.0490551578723161 no 228 0.0584766552182201 71 6793154 SGTC_1856 st057054 55.7 µM 1.56450055384184 0.0493974064325288 no 229 0.0588500315051279 87 1266018 SGTC_1831 st055328 12 µM 1.56033472476466 0.0498471823215385 no 230 0.0593404007469218 98 1103068 SGTC_602 3130-1533 38.1 µM 1.55725967997225 0.0501812794215284 no 231 0.0597044220598289 110 720941 SGTC_1227 3909-8010 46.6 µM 1.5551679525209 0.0504095595214308 no 232 0.0599530373147155 72 15982272 SGTC_3092 9117248 49.47 µM 1.55250081166077 0.0507018365781097 no 233 0.0602712193259059 72 17141857 SGTC_1881 5652484 16 µM 1.54961807955053 0.051019255046482 no 234 0.0606166054614064 79 2255129 SGTC_2969 9091408 28.7 µM 1.54757460683818 0.0512452188919983 no 235 0.0608623745282862 89 4286311 SGTC_1241 0364-0022 50.8 µM 1.5455130506067 0.0514739884885197 no 236 0.0611111073300298 90 4563895 SGTC_3023 9089636 49.47 µM 1.54265895339985 0.0517920455695131 no 237 0.0614567729885873 81 17249241 SGTC_100 0086-0128 49.5915 µM 1.54094616211589 0.0519836656307516 no 238 0.0616649447926996 95 93297 SGTC_1307 1187-1599 12.2 µM 1.53709110346996 0.0524170144303369 no 239 0.0621355006340234 110 1538471 SGTC_3301 9125354 19.7965 µM 1.53638436338674 0.0524967695909212 no 240 0.0622220697418526 80 41905162 SGTC_2295 7971645 200 µM 1.53361105406035 0.0528106667726158 no 241 0.0625626836178583 75 2978226 YKL099C UTP11 SGTC_48 0382-0018 55 µM 1.52173667750197 0.0541715379921967 no 242 0.0640375367757353 64 762596 SGTC_3191 9110352 49.47 µM 1.52089227787885 0.0542693582532111 no 243 0.0641434360612169 73 17122424 SGTC_1179 1021-1431 9.29 µM 1.51902090736416 0.0544866469973885 no 244 0.0643786167185064 110 2840958 SGTC_2655 perillic acid 100 µM 1.51880176409301 0.0545121371246537 no 245 0.0644062008695038 80 5702197 An apoptosis inducer. SGTC_2431 5490079 200 µM 1.51770210443862 0.0546401888646786 no 246 0.0645447566608906 126 5722345 SGTC_2035 5154463 94.595 µM 1.51709174182377 0.0547113661531716 no 247 0.0646217614800959 116 2769623 SGTC_3079 9117512 49.47 µM 1.51574207595988 0.0548690173641372 no 248 0.0647922919137352 96 7185044 SGTC_951 1171-0579 82.7 µM 1.51457954762179 0.0550050971186258 no 249 0.0649394574295049 118 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1760 st045453 10.4495 µM 1.50370624876964 0.0562908187235377 no 250 0.0663285097818993 101 3323419 YIL048W NEO1 SGTC_352 k048-0007 5.11 µM 1.50298867051435 0.0563764957615589 no 251 0.0664209827818901 127 6811911 SGTC_3256 9138902 49.47 µM 1.49832786762724 0.0569354883532755 no 252 0.0670240435605081 86 17228773 SGTC_1276 0871-0068 94.2 µM 1.49511045384582 0.0573239080213543 no 253 0.0674428090285233 113 3414906 SGTC_2072 5231554 129 µM 1.49420087084686 0.0574340939095803 no 254 0.0675615625368663 104 789545 SGTC_1199 1638-0010 4.46 µM 1.48467870035993 0.0585976261637342 no 255 0.0688144783026867 104 3111136 SGTC_1330 1469-0054 61.8 µM 1.4782147040245 0.0593979630760709 no 256 0.0696751597140077 102 7102664 SGTC_699 0375-0592 111 µM 1.47802656182531 0.0594213855276055 no 257 0.069700334406441 67 762578 SGTC_1588 farnesol 29.9 µM 1.47750078394291 0.0594868797649856 no 258 0.0697707241518498 98 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2007 4011539 71.82 µM 1.4772805420197 0.0595143313093057 no 259 0.0698002258101923 74 45595301 SGTC_478 N-arachidonylglycine 10 µM 1.47628278609453 0.0596388186846235 no 260 0.069933996646159 49 5283389 SGTC_372 0155-0182 15.9 µM 1.47591345388461 0.059684951001373 no 261 0.0699835636407445 93 771486 SGTC_247 mechlorethamine 29.705 µM 1.4738908153098 0.0599380895154051 no 262 0.0702554955433822 74 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_154 3389-1638 511.116 µM 1.47089245008753 0.0603148889814614 no 263 0.0706601023863401 97 5238686 SGTC_268 camptothecin 39.6153 µM 1.46939827256441 0.0605033505954143 no 264 0.0708623977985556 160 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3285 9112818 20.8695 µM 1.46805080497748 0.0606737024008443 no 265 0.0710452115562709 126 17017947 YPR165W RHO1 SGTC_2109 5483026 200 µM 1.46516341773432 0.0610399996104645 no 266 0.0714381688588539 153 759335 SGTC_153 4077-0274 519.67 µM 1.46447923622844 0.0611270484636532 no 267 0.0715315261498732 107 3121976 SGTC_354 2783-3500 4.88 µM 1.46290794640266 0.0613273319355313 no 268 0.0717462846680934 128 6740761 SGTC_3022 9087993 49.47 µM 1.46189347609216 0.0614569128710102 no 269 0.071885201509269 93 17173644 SGTC_3227 9130768 49.47 µM 1.45922898488975 0.0617982738150967 no 270 0.0722510468390906 82 17720899 SGTC_3243 9134147 49.47 µM 1.45703966696994 0.0620798641839413 no 271 0.0725527154673817 87 24282180 SGTC_2905 7799065 20.05 µM 1.45002203232834 0.0629892240320701 no 272 0.0735261876786973 108 1296806 SGTC_3212 9128307 49.47 µM 1.44849266749355 0.063188772632143 no 273 0.0737396575977615 96 27243542 SGTC_3283 9109332 35.8195 µM 1.44812594162681 0.0632366954160652 no 274 0.0737909158264003 80 17027281 SGTC_3272 9137413 49.47 µM 1.44737129740059 0.0633353993914712 no 275 0.0738964800872202 103 17614870 SGTC_2154 5570129 200 µM 1.44052834891184 0.064235908319359 no 276 0.0748589877439149 95 673366 SGTC_1780 st038448 24.544 µM 1.43733209136849 0.0646599201763469 no 277 0.0753118272266458 104 728868 YDL195W SEC31 SGTC_3172 9105863 49.47 µM 1.43672073090636 0.0647412696509409 no 278 0.0753986809853472 80 2348785 SGTC_1352 1496-0991 99 µM 1.43622180496977 0.0648077171249011 no 279 0.0754696181362947 104 3000039 SGTC_2326 6164455 177.58 µM 1.43604708553998 0.0648309989545804 no 280 0.0754944717167447 124 2888790 SGTC_1432 4049-0298 68.4 µM 1.43574914278468 0.0648707155989786 no 281 0.0755368680189104 93 741646 SGTC_3343 9148379 18.9835 µM 1.42745831210019 0.0659835012152895 no 282 0.076723916577793 91 1955036 SGTC_357 1325-0123 420 µM 1.42714935487206 0.0660252531814742 no 283 0.0767684244555349 104 1098503 SGTC_3046 9092212 49.47 µM 1.426785430613 0.0660744595533272 no 284 0.076820875973154 92 25236637 SGTC_2379 9035213 200 µM 1.42554937023727 0.0662418000029859 no 285 0.0769992297860137 113 646551 SGTC_2654 protoveratrine a 100 µM 1.42418441743558 0.0664269713386973 no 286 0.0771965472341578 108 5702278 A heart drug and vasodilator. SGTC_2796 7949634 45.45 µM 1.41941073734434 0.0670777281256351 no 287 0.0778896519238807 124 2971588 SGTC_3082 9117008 49.47 µM 1.41743551974394 0.0673484310901417 no 288 0.0781778169704 103 41448529 SGTC_2822 7994718 71.43 µM 1.41606715801653 0.0675364592488794 no 289 0.0783779212945131 126 1018011 SGTC_1497 4476-2978 41.3 µM 1.41155128813534 0.0681598692858367 no 290 0.0790410619832733 108 1528379 SGTC_161 4065-0411 162.148 µM 1.41014224108372 0.0683552928981541 no 291 0.0792488432984107 115 1906281 YLR208W SEC13 SGTC_1901 st060216 58.6 µM 1.40903404811225 0.0685092939492547 no 292 0.0794125502850056 99 688792 SGTC_1390 3413-2614 145 µM 1.40767267383692 0.0686988447624858 no 293 0.079614008484491 135 3421432 SGTC_1857 st056007 79.3 µM 1.40539438197088 0.0690169669217782 no 294 0.0799520182054951 76 619834 SGTC_1758 st042942 75.2445 µM 1.40260156123231 0.0694084812372448 no 295 0.0803678430030356 112 669317 SGTC_2627 acetyl isogambogic acid 100 µM 1.40016186475609 0.06975189033611 no 296 0.0807324263799877 110 6857789 A caspase activator and apoptosis inducer. SGTC_1302 1159-0335 255 µM 1.39898329793993 0.0699182519506893 no 297 0.0809089958212225 99 649284 SGTC_932 2857-0803 154 µM 1.39661769798976 0.0702530915184078 no 298 0.0812642826816164 115 674898 SGTC_861 0443-0273 110 µM 1.39653813392378 0.0702643748375746 no 299 0.0812762527482702 121 6149169 SGTC_2732 terfenadine 20 µM 1.39388719879796 0.0706411125574516 no 300 0.0816758352619221 107 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1791 st048313 56.1 µM 1.39310226030081 0.0707529614771469 no 301 0.0817944348576048 83 1204976 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.38900044548872 0.0713396596404527 no 302 0.0824163072911475 118 689007 SGTC_3135 9127742 49.47 µM 1.38854778178708 0.0714046339776065 no 303 0.08248515274372 104 3643468 SGTC_1704 st028805 70.8 µM 1.38599702964387 0.0717716126137734 no 304 0.0828739052484024 118 2876101 SGTC_1986 st071812 45 µM 1.38505721637912 0.0719071883561897 no 305 0.0830174863433766 102 11838594 SGTC_205 1486-1330 71.903 µM 1.3815834677367 0.0724100098674244 no 306 0.0835498165212877 108 4118834 SGTC_1968 st069590 43.6 µM 1.38090735455851 0.0725081889852431 no 307 0.0836537241715665 125 6384066 SGTC_500 h-89 112 µM 1.38031322659642 0.0725945470882982 no 308 0.0837451121381775 120 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_157 1348-1695 65.819 µM 1.37974810366707 0.0726767623125017 no 309 0.0838321081644014 142 5380510 SGTC_2889 9059656 51.95 µM 1.37936181585072 0.0727330012587211 no 310 0.0838916130403992 117 3949838 SGTC_2700 st077718 96.8 µM 1.37926717488427 0.072746784947255 no 311 0.0839061966411342 113 904970 SGTC_2810 7959871 45.46 µM 1.37711558162465 0.0730606869380595 no 312 0.0842382580108579 118 2974535 SGTC_2124 5246320 200 µM 1.376768945097 0.0731113555226616 no 313 0.0842918475151351 132 579342 SGTC_3088 9117578 49.47 µM 1.37314212397139 0.0736431091805377 no 314 0.0848540839221539 115 678341 SGTC_414 piperonyl butoxide 100 µM 1.36843688192025 0.0743373777024199 no 315 0.0855876831315379 115 5794 A potent inhibitor of cytochrome P450. SGTC_3098 9119039 49.47 µM 1.36563368542647 0.0747533645599895 no 316 0.0860269840614543 119 17161528 SGTC_976 1348-1067 47.6 µM 1.36429172180038 0.074953135992356 no 317 0.0862378851298468 114 5310671 YGL099W LSG1 SGTC_2406 ethylparaben 405.7 µM 1.36248338628496 0.0752229776428033 no 318 0.0865226918766782 100 8434 A possible steroid mimic. SGTC_3103 9120822 49.47 µM 1.36173186919848 0.0753353373965288 no 319 0.08664125990062 146 17141819 SGTC_3067 9117431 49.47 µM 1.36046884268631 0.0755244613298296 no 320 0.0868408030593766 157 17150885 SGTC_2713 st079149 53.4 µM 1.35812195284531 0.075876841933334 no 321 0.0872124951993055 112 3103253 SGTC_1699 st031318 29.054 µM 1.35665507953473 0.0760977249008537 no 322 0.0874454159256223 122 5340658 SGTC_1098 clofazimine 15.1 µM 1.35628544671595 0.0761534616463226 no 323 0.0875041820642554 142 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_528 3492-0019 172 µM 1.34891115540895 0.0772719317197184 no 324 0.0886827523339197 139 2869262 SGTC_1498 4478-3555 97.6 µM 1.3476676047384 0.077461766404667 no 325 0.0888826579636871 80 3437919 SGTC_1640 st009078 66.4 µM 1.34414256989191 0.0780018068135954 no 326 0.0894511442757528 121 690618 SGTC_2066 5222451 176 µM 1.34138971530021 0.0784255308892962 no 327 0.0898969775016513 153 2281147 SGTC_929 2805-0021 398 µM 1.34057035391367 0.0785519847985498 no 328 0.0900299939779447 132 3098024 SGTC_1966 st070145 16.1 µM 1.33620574498285 0.0792281904878059 no 329 0.0907410169093805 135 3748532 SGTC_393 acivicin 6.25 µM 1.33439879586062 0.0795094262723127 no 330 0.0910365972354346 133 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1381 2324-0066 62.1 µM 1.3334769561809 0.0796531932325234 no 331 0.091187666387264 135 10885928 SGTC_2853 9015042 58.44 µM 1.33343186083849 0.0796602311901747 no 332 0.0911950612838058 101 6457456 SGTC_3019 9081971 49.47 µM 1.33203157648219 0.079879005506954 no 333 0.0914249062955674 108 16451803 SGTC_3013 9080133 71.4286 µM 1.33052825799717 0.080114382860609 no 334 0.0916721411462449 116 17050193 SGTC_1904 st060225 78 µM 1.32877594816989 0.080389406572963 no 335 0.0919609497810122 105 66595 SGTC_809 3998-0021 90 µM 1.32400570584913 0.0811417063786681 no 336 0.0927505748663755 132 715485 SGTC_135 0933-0004 26.348 µM 1.32359109214001 0.0812073438961727 no 337 0.0928194425914582 133 21230617 YGL099W LSG1 SGTC_99 0109-0120 622.8 µM 1.32048723707273 0.0816999884296859 no 338 0.0933361972318936 109 759414 SGTC_1957 st077035 62.4 µM 1.31979264125098 0.0818105427008649 no 339 0.0934521295872113 119 705593 SGTC_588 3970-1144 52.9 µM 1.31864987083764 0.0819926752903348 no 340 0.0936430964512488 85 1888707 SGTC_3248 9135562 49.47 µM 1.31594832731308 0.0824244568193467 no 341 0.0940956933117494 116 17650701 SGTC_2475 5812728 15.03 µM 1.31572774168717 0.0824597879738094 no 342 0.0941327197626862 126 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1458 k015-0034 6.33 µM 1.31463023129639 0.0826357454974351 no 343 0.0943171024154501 103 3598957 SGTC_759 3486-0358 89.3 µM 1.30958017157336 0.0834490357194977 no 344 0.0951689499428244 142 875103 SGTC_2805 7950783 58.44 µM 1.30481387626647 0.0842221313983122 no 345 0.0959781164585125 129 1178958 YDL195W SEC31 SGTC_1928 4'-methoxychalcone 40.3 µM 1.30131820211257 0.0847925398811118 no 346 0.0965747796572366 142 641818 SGTC_2760 etidronate 98.04 µM 1.30034479553491 0.0849518904654882 no 347 0.0967414107018757 118 3305 A chelator and antioxidant. SGTC_3349 9149703 23.001 µM 1.29783919385103 0.0853631000573112 no 348 0.0971712991788499 107 4910494 SGTC_740 k014-0057 261 µM 1.29193640149346 0.086337734543216 no 349 0.0981895851209961 133 4012779 SGTC_2970 9090938 41.86 µM 1.29164647705182 0.0863858186897704 no 350 0.0982398003953706 133 17217104 SGTC_2360 9040895 200 µM 1.28852721386113 0.0869044176903672 no 351 0.0987812509756526 118 4914414 SGTC_3057 9095946 49.47 µM 1.28816681449493 0.0869644861416515 no 352 0.0988439505853698 148 24540043 SGTC_972 1319-0219 195 µM 1.28497584084219 0.0874976854096767 no 353 0.0994003632512168 141 23903702 SGTC_2895 9054447 58.44 µM 1.28247152604568 0.0879178525252509 no 354 0.0998386436257855 127 2697450 SGTC_1282 0886-0010 32.4 µM 1.28151771792782 0.0880782749183442 no 355 0.100005940329121 145 2836211 YNL267W PIK1 SGTC_3335 9143315 29.6265 µM 1.28015238770862 0.0883082914701938 no 356 0.100245773580866 115 4899691 SGTC_2536 dehydroabietamide 32.04 µM 1.27862627946407 0.088565923735484 no 357 0.100514345608682 111 3983547 SGTC_2553 4-methylesculetin 85.09 µM 1.27678121485827 0.0888781482552936 no 358 0.100839749676705 115 5319502 SGTC_843 0310-0051 143 µM 1.27537125304226 0.089117295899543 no 359 0.10108893431566 135 2065037 SGTC_2649 anisomycin 9.56 µM 1.27089808358667 0.0898791724646663 no 360 0.101882454145034 135 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2450 5739737 12.93 µM 1.26892095837009 0.090217457759399 no 361 0.102234628235553 119 2262825 SGTC_3020 9089140 49.47 µM 1.26824263618305 0.0903337360274833 no 362 0.102355657693185 128 17217859 SGTC_2488 5268135 45.7 µM 1.26761308580147 0.0904417533602872 no 363 0.102468078252306 146 1270356 YLR208W SEC13 SGTC_2949 9072542 2.23 µM 1.26745814186613 0.0904683531143489 no 364 0.102495760782774 129 16457352 SGTC_112 phenothiazine 287.218 µM 1.26643950641242 0.0906433703690925 no 365 0.102677887201006 124 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1411 3909-8223 150 µM 1.26635683232731 0.0906575860683014 no 366 0.102692679186273 148 X1411 SGTC_570 0987-0065 62.6 µM 1.26561206358526 0.0907857226699362 no 367 0.102826002475702 119 3104428 SGTC_663 1486-0733 13.9 µM 1.26444794621989 0.090986276848406 no 368 0.103034646485356 138 722445 YPR165W RHO1 SGTC_682 0kpi-0099 17 µM 1.26296433901722 0.0912423488282106 no 369 0.103300997918643 173 1714895 YML126C ERG13 SGTC_646 4092-0839 27.3 µM 1.26146375212213 0.0915018947030432 no 370 0.103570905861369 145 877796 SGTC_1210 3013-0140 750 nM 1.26005145470179 0.0917466692308805 no 371 0.103825400477738 131 905973 SGTC_2720 fluspirilene 36.88 µM 1.25927789102196 0.0918809460693217 no 372 0.103964988017676 124 3396 An atypical antipsychotic. SGTC_1608 st001473 40.5 µM 1.25922928896248 0.0918893873759807 no 373 0.103973762673718 164 7292267 SGTC_586 0957-0265 8.15 µM 1.25649869858636 0.0923645651071583 no 374 0.104467608736115 140 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_514 4466-0038 2.65 nM 1.25309014725145 0.0929602703060433 no 375 0.10508645066486 159 5722064 SGTC_251 melphalan 456.522 µM 1.25196737023642 0.0931571161821643 no 376 0.10529087700672 154 460612 A DNA alkylator. SGTC_2075 5212009 200 µM 1.25189183780568 0.0931703696188118 no 377 0.10530463967474 128 780898 SGTC_1842 st055362 61.2 µM 1.25045736781531 0.0934223361054237 no 378 0.105566259731755 124 676032 SGTC_2068 5226020 147 µM 1.2489461168152 0.093688333361944 no 379 0.105842391275952 132 1810509 SGTC_2179 6298986 200 µM 1.24809478032325 0.0938384242175833 no 380 0.10599817478588 139 738374 SGTC_45 0kpi-0036 14.9 µM 1.24698180553193 0.0940349095591082 no 381 0.106202084496538 136 2795021 SGTC_1087 pterostilbene 9.05 µM 1.24660844811919 0.0941008902875377 no 382 0.106270551271999 156 5281727 Similar to reservatol, lowers cholesterol. SGTC_109 0132-0036 33.701 µM 1.2447596205571 0.0944281234860134 no 383 0.10661006152798 124 67274 A color developer. SGTC_2930 9013230 14.89 µM 1.23638301099971 0.0959212581531813 no 384 0.108158114033858 150 2995857 SGTC_2005 4024620 188 µM 1.23605939454711 0.095979289338215 no 385 0.10821824344334 138 236743 SGTC_2262 9014885 67.46 µM 1.23339858780764 0.096457406620868 no 386 0.10871354581208 117 6457424 SGTC_1597 7-benzyloxygramine 47.5 µM 1.2311682450086 0.0968595206883992 no 387 0.109129972713443 173 260807 SGTC_3221 9128209 49.47 µM 1.22990382290055 0.0970880324964093 no 388 0.10936656125028 133 16460723 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.22932905891658 0.0971920370318839 no 389 0.109474228200894 130 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_850 0388-0143 75.9 µM 1.22546722364883 0.0978929636251403 no 390 0.110199616060347 132 67273 SGTC_2772 vinpocetine 57.06 µM 1.22293356914362 0.0983548325596417 no 391 0.110677394114521 133 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1371 2421-0008 32.7 µM 1.22021877905822 0.0988514902577752 no 392 0.111190974908185 163 2827552 SGTC_3345 9148410 3.559 µM 1.21852171330584 0.0991628909057503 no 393 0.111512889297117 137 4903596 SGTC_3163 9099914 49.47 µM 1.21630947117777 0.0995698994014674 no 394 0.111933527471463 155 16268368 SGTC_2188 6126565 140.678 µM 1.2161590373058 0.0995976205034107 no 395 0.111962172278899 135 874518 SGTC_1943 st076331 65.2 µM 1.21543329931112 0.0997314346265857 no 396 0.112100437035975 132 24208415 SGTC_1855 st056195 39.6 µM 1.21397912564923 0.0999999554512578 no 397 0.112377847715469 130 4028379 SGTC_449 xestospongin c 11.1929 µM 1.21207978748759 0.100351472839234 no 398 0.112740920047024 128 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3206 9114350 49.47 µM 1.21018008056593 0.100703959639904 no 399 0.11310489992286 125 17087243 SGTC_1929 genistein trimethyl ether 50.5 µM 1.20704110213491 0.101288368081825 no 400 0.11370815767842 138 136420 SGTC_2331 7980721 200 µM 1.20674059621852 0.101344444979883 no 401 0.113766029821634 159 2981221 SGTC_1157 4092-0394 27.6 µM 1.20287971340862 0.102066930729349 no 402 0.114511435896062 125 3659885 SGTC_886 0866-0150 153 µM 1.2028159736285 0.102078889697979 no 403 0.114523770996085 140 271463 SGTC_442 cape 100 µM 1.20074980566634 0.102467100055669 no 404 0.114924133915184 132 5281787 SGTC_874 0599-0792 117 µM 1.19759699994974 0.103061544737353 no 405 0.115536972304534 163 765305 SGTC_2106 5357045 167.29 µM 1.19553386323734 0.103451891598587 no 406 0.115939256948225 148 668842 SGTC_2312 7706453 155.7 µM 1.19479834568222 0.103591311168476 no 407 0.116082913425613 149 976098 SGTC_3258 9138477 49.47 µM 1.19314227924364 0.103905722545499 no 408 0.116406827868566 138 4970355 SGTC_373 0844-0104 25.9 µM 1.19233546138673 0.104059150887823 no 409 0.116564867591235 157 5375804 SGTC_322 k048-0136 19.3 µM 1.19178439305218 0.104164039049141 no 410 0.116672898443741 151 6823282 SGTC_110 0850-0284 111.64 µM 1.19108517540635 0.104297235653393 no 411 0.116810074490535 111 3906265 SGTC_1388 3346-4487 254 µM 1.19057187226407 0.104395095245677 no 412 0.116910849638379 152 3345614 SGTC_470 aa-861 153 µM 1.18966881460175 0.104567421748346 no 413 0.117088293568574 150 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2719 novobiocin 32.65 µM 1.18949227076164 0.1046011348959 no 414 0.117123005371289 141 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_169 k015-0017 16.025 µM 1.18944426001995 0.10461030448004 no 415 0.117132446436941 152 1840002 SGTC_3229 9132204 49.47 µM 1.1892952456918 0.104638768473778 no 416 0.11716175277258 114 17682924 SGTC_2137 5261020 140 µM 1.18894503244743 0.104705686591933 no 417 0.117230648926477 133 763655 SGTC_1285 0929-0069 65.5 µM 1.18794672658307 0.104896611171563 no 418 0.117427199424625 126 1206237 SGTC_101 0490-5701 117.494 µM 1.18584636189989 0.105299125672005 no 419 0.117841489380774 121 4661669 SGTC_2088 5278280 127.392 µM 1.18213614756237 0.106012880452905 no 420 0.118575841748532 140 791502 SGTC_3247 9135149 49.47 µM 1.17996677322768 0.10643183136629 no 421 0.119006715164326 165 8934436 YOR116C RPO31 SGTC_1012 4112-3522 18 µM 1.17813637104671 0.106786248552286 no 422 0.119371122103918 141 3112398 SGTC_2575 plumbagin 510 nM 1.17576542427479 0.107246595273741 no 423 0.119844313280404 158 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3241 9133421 49.47 µM 1.17512310132749 0.107371555665363 no 424 0.119972734812964 141 17018221 SGTC_564 3555-0129 330 µM 1.171459675141 0.108086261665773 no 425 0.120707028774932 140 563260 SGTC_3059 1327-0034 3 µM 1.17051976237088 0.108270182197731 no 426 0.120895932990935 150 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_978 1416-0512 87.4 µM 1.17028203299769 0.108316736345594 no 427 0.120943744925061 138 6814003 SGTC_399 oxolinic acid 75 µM 1.16797060573134 0.108770130394203 no 428 0.121409310915932 139 4628 A DNA gyrase inhibitor. SGTC_446 go6976 132 µM 1.16717182418348 0.108927130864733 no 429 0.121570493487419 139 3501 A protein kinase C inhibitor. SGTC_1792 st045773 43.6 µM 1.16600289365617 0.109157177630675 no 430 0.121806637769954 68 2919270 SGTC_3333 9141820 12.094 µM 1.16573398200741 0.109210149087535 no 431 0.121861008162068 144 1939433 SGTC_3106 9121286 49.47 µM 1.16418677024897 0.109515284864718 no 432 0.12217416523275 122 15943471 SGTC_1129 3453-1384 223 µM 1.16416158825549 0.109520256229143 no 433 0.122179266759724 154 1084452 SGTC_3012 9080433 71.4286 µM 1.16281694651442 0.109785947349455 no 434 0.122451889994292 168 17688859 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.16069009690666 0.110207140971285 no 435 0.12288397529173 159 7104 SGTC_2725 haloperidol 53.21 µM 1.15842706219416 0.110656575553847 no 436 0.123344900354107 167 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2031 5180455 200 µM 1.15784651296385 0.110772082991644 no 437 0.123463339070609 149 29949 SGTC_2697 mebhydrolin 72.4 µM 1.15695182808567 0.110950260714891 no 438 0.123646021013367 133 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3193 9111931 49.47 µM 1.15638280375414 0.111063689444147 no 439 0.123762306124092 151 17087244 SGTC_779 1360-0071 233 µM 1.15551136839145 0.111237561421025 no 440 0.12394053995391 158 7566 SGTC_2731 amoxapine 43.43 µM 1.1540885705294 0.111521861949084 no 441 0.12423192936284 155 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3341 9147222 25.867 µM 1.15162612880359 0.112015129910937 no 442 0.124737369810997 157 1939759 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.15072699636196 0.112195629262902 no 443 0.124922283299003 154 688662 SGTC_2290 7904846 200 µM 1.14931359167365 0.112479787992402 no 444 0.125213347801481 145 2962154 SGTC_1207 2099-0101 141 µM 1.14616479963841 0.113114686254013 no 445 0.125863484824069 159 5837381 SGTC_2734 clemastine 41.6 µM 1.14615670808191 0.113116321060791 no 446 0.125865158530089 161 26987 Clemastine is a selective histamine H1 antagonist. SGTC_501 nsc-95397 161 µM 1.1457333963301 0.113201869889599 no 447 0.125952740516944 164 262093 SGTC_271 rotenone 740 µM 1.14064162946122 0.114234504583009 no 448 0.127009543026952 141 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2486 5283202 22.39 µM 1.13967676067757 0.114430938239734 no 449 0.127210496237974 138 1377751 SGTC_3203 9113543 49.47 µM 1.13963292028446 0.114439869232249 no 450 0.127219632126934 159 17018012 SGTC_1093 fluphenazine 7.97 µM 1.13859513275617 0.114651428144689 no 451 0.127436029724881 166 6602611 An atypical antipsychotic. SGTC_2128 5255449 168.493 µM 1.13839496589198 0.114692265299329 no 452 0.127477797592149 137 736008 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.13789530555108 0.114794248944727 no 453 0.127582100875801 142 2724 A muscle relaxant with antifungal properties. SGTC_419 nsc-638432 893 µM 1.13782646932391 0.114808303882511 no 454 0.127596474975158 146 368090 SGTC_1085 doxorubicin 7.67 µM 1.13749151246163 0.114876712637206 no 455 0.127666435365709 176 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1259 0671-0132 43 µM 1.13438534515358 0.115512471365041 no 456 0.128316471787496 152 X1259 SGTC_1251 0490-5699 265 µM 1.13325906792008 0.115743610018711 no 457 0.128552737736519 158 3883818 SGTC_925 2064-1272 59.6 µM 1.13096071656106 0.116216304615622 no 458 0.129035813001294 158 6815817 SGTC_2018 5133068 143 µM 1.12649335187203 0.117139008938492 no 459 0.12997837650454 153 785362 SGTC_3037 9091026 49.47 µM 1.12514248670524 0.117419040361201 no 460 0.130264329951269 158 25236398 YIL048W NEO1 SGTC_567 1080-0542 68.4 µM 1.11644439958071 0.11923348998008 no 461 0.132115978656066 131 5950415 SGTC_2956 9076196 2.52 µM 1.11410036634471 0.119725830453581 no 462 0.1326180657549 170 16423868 SGTC_106 0092-0003 11.579 µM 1.11060081971045 0.120463539878209 no 463 0.133370104896813 148 1072148 SGTC_376 3970-0862 59.1 µM 1.10641985346977 0.121349083140774 no 464 0.134272418113925 186 3135186 SGTC_2363 9053361 176 µM 1.10373352665212 0.121920466186654 no 465 0.13485437381626 164 6469797 YMR079W SEC14 SGTC_1041 0206-0046 107 µM 1.10369899779664 0.121927822772024 no 466 0.134861865263771 160 50494 SGTC_2195 6536160 144.242 µM 1.0987079183062 0.122994484550703 no 467 0.135947743807011 136 3834386 SGTC_2874 9043904 71.43 µM 1.09834529181065 0.123072236911223 no 468 0.136026870832884 161 4463428 SGTC_3330 9141424 71.43 µM 1.09682216714726 0.123399193098969 no 469 0.136359568998158 142 27261020 SGTC_2143 5623677 140.463 µM 1.09591175928147 0.123594912901637 no 470 0.136558696218372 151 5375313 SGTC_2036 5160441 105 µM 1.0958180090903 0.123615079689423 no 471 0.136579212837537 189 134534 YIL048W NEO1 SGTC_3169 9102970 49.47 µM 1.09364545957447 0.124083066628059 no 472 0.13705525164049 163 17027839 SGTC_2029 5175081 200 µM 1.09344364952474 0.124126601189746 no 473 0.137099528780981 147 1380876 SGTC_1965 Pectolinarigenin 58.4 µM 1.09124115267146 0.124602419670573 no 474 0.137583392103011 148 5320438 An anti-inflammatory. SGTC_3141 9094609 49.47 µM 1.09066623941967 0.12472683116285 no 475 0.137709885568285 204 25236309 YDL196W YDL196W SGTC_2094 5332512 191.667 µM 1.09038936449382 0.124786777986155 no 476 0.137770832401468 165 755774 SGTC_2238 6671620 73.2395 µM 1.08861218684806 0.125172038149268 no 477 0.138162470154816 143 729941 SGTC_1161 k007-0610 110 µM 1.08528156225669 0.1258962928774 no 478 0.138898484733833 200 5843850 SGTC_2095 5432005 200 µM 1.0841335568464 0.126146606183364 no 479 0.139152793087434 165 783734 SGTC_1728 st035614 33.7865 µM 1.08260519340867 0.126480391559277 no 480 0.139491850575927 182 15945546 SGTC_729 4092-0585 94.1 µM 1.08250637031488 0.126501995086433 no 481 0.13951379316109 158 2169061 SGTC_284 0988-0104 32.6 µM 1.08246358808943 0.126511348424008 no 482 0.139523293213591 180 4666532 SGTC_2544 sphondin 68.51 µM 1.08025947781513 0.126993877695686 no 483 0.140013324540402 176 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_914 3820-6779 408 µM 1.07857353510138 0.127363832030175 no 484 0.140388942157276 149 2893481 SGTC_1299 1079-1439 3.74 µM 1.07706168669315 0.127696220949113 no 485 0.14072635403515 172 323161 SGTC_1632 st005650 90 µM 1.07674539674377 0.127765835387558 no 486 0.14079701266158 155 2759605 SGTC_1351 1496-0003 46.5 µM 1.07463709827717 0.128230539240077 no 487 0.141268617841876 171 3891978 SGTC_457 grayanotoxin iii 135 µM 1.0737797351895 0.128419851543918 no 488 0.141460707284775 181 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2653 dihydrofissinolide 100 µM 1.07165256750625 0.128890383947196 no 489 0.14193805642447 157 6857746 SGTC_1032 k061-1018 98.7 µM 1.06953843041898 0.129359217465368 no 490 0.142413560828809 155 4005393 SGTC_2709 st078560 56 µM 1.068996304096 0.129479630180208 no 491 0.142535667395352 186 17250903 SGTC_872 0588-0139 234 µM 1.06674320017016 0.129980903353256 no 492 0.143043906827592 143 2047100 SGTC_2568 diosmetin 100 µM 1.06481234077096 0.130411550793152 no 493 0.143480429723473 199 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1166 k206-0078 225 µM 1.06126289371968 0.131205770695491 no 494 0.14428522196364 174 5404595 SGTC_1061 3448-9325 110 µM 1.05984656716862 0.131523616740185 no 495 0.144607203811841 186 723482 SGTC_2248 tofa 1.1 µM 1.05950623065524 0.131600072764674 no 496 0.144684646589089 180 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2374 9071832 200 µM 1.05826028980624 0.131880232950545 no 497 0.144968395809331 157 17381698 SGTC_2872 9044037 25.97 µM 1.05707434114468 0.132147285325039 no 498 0.145238830245892 157 6465195 SGTC_723 4182-0001 115 µM 1.05393680180774 0.132855594798428 no 499 0.145955926178533 159 744821 YLR208W SEC13 SGTC_888 0916-0002 6.97 µM 1.05390048684882 0.13286380829078 no 500 0.14596423999662 144 2802138 YIL048W NEO1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.0527216253865 0.133130625783132 no 501 0.146234297192162 186 6728940 SGTC_1653 st012112 65 µM 1.04979521224169 0.133794568387166 no 502 0.146906138485618 158 720429 SGTC_1656 st012921 11 µM 1.04818181275057 0.134161587090287 no 503 0.147277424147743 161 6732821 SGTC_1182 1222-0449 220 µM 1.04502527161145 0.134881640761979 no 504 0.148005644839305 164 658318 SGTC_1163 k060-0048 49.9 µM 1.0419961177411 0.135575124120303 no 505 0.148706739436944 168 6809982 SGTC_202 3594-0513 34.79 µM 1.04161621700513 0.135662269285386 no 506 0.148794823482303 164 708429 SGTC_3308 9128332 17.569 µM 1.0362815568858 0.136890036334534 no 507 0.15003540389037 177 17332805 YDL196W YDL196W SGTC_1493 4348-0038 111 µM 1.03626657957669 0.136893494004795 no 508 0.150038896558056 210 800424 SGTC_2721 ifenprodil 61.44 µM 1.03616217779191 0.136917597919574 no 509 0.150063244275811 175 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_467 ro 31-8220 72.8 µM 1.03391363128474 0.137437438410999 no 510 0.150588270934384 180 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2218 6965428 192.983 µM 1.03282840024815 0.137688814037927 no 511 0.150842105267469 162 675684 SGTC_1318 1280-3875 124 µM 1.03216311089534 0.137843072237772 no 512 0.15099785645596 199 373245 SGTC_342 k048-0088 23.3 µM 1.030596425524 0.138206799446126 no 513 0.1513650565072 188 6820570 SGTC_1416 3966-0321 25.3 µM 1.0302638838938 0.138284087596385 no 514 0.15144307402363 176 582530 YLR208W SEC13 SGTC_1440 4100-1550 40 µM 1.026503271324 0.139160166529997 no 515 0.152327211219893 184 742806 SGTC_3072 9116419 49.47 µM 1.02505407434248 0.139498780166339 no 516 0.152668836821309 168 17170162 SGTC_613 3914-0030 117 µM 1.02433598983442 0.139666772421369 no 517 0.152838302221081 141 1145395 SGTC_816 0325-0417 81.3 µM 1.02392706899199 0.139762498838758 no 518 0.152934861814911 178 68101 SGTC_3318 9139014 38.6185 µM 1.02342904077324 0.139879145095699 no 519 0.153052517193013 197 16643984 SGTC_1977 st070720 65.3 µM 1.02303331316899 0.139971878059303 no 520 0.153146047596351 149 682188 SGTC_2346 9031566 143.75 µM 1.01821566233445 0.14110417419677 no 521 0.154287738902827 166 4771086 SGTC_2049 5262831 67.185 µM 1.01765350937366 0.141236700967979 no 522 0.154421324178341 154 763417 SGTC_362 0310-0100 9.03 µM 1.01765135845184 0.141237208206779 no 523 0.154421835452016 165 790235 SGTC_2255 7941087 197.44 µM 1.01213397865822 0.142542404100115 no 524 0.155736998979023 170 935561 SGTC_150 3970-0969 77.2 µM 1.00872701559016 0.14335241916108 no 525 0.156552785871572 224 6615640 SGTC_813 k007-0158 173 µM 1.00845904929788 0.1434162604885 no 526 0.156617068710944 183 6523916 SGTC_466 geldanamycin 89.2 µM 1.00765518160182 0.143607892197261 no 527 0.156810013984449 146 5288382 HSP90 inhibitor. SGTC_175 3793-3120 23.7 µM 1.00581080130697 0.144048221596274 no 528 0.157253295226792 195 5322297 SGTC_2054 5233173 129 µM 1.00458176830177 0.144342147291191 no 529 0.15754913992443 121 6889 SGTC_3009 9080819 71.4286 µM 1.00381152171188 0.144526559207509 no 530 0.157734734895836 170 17027216 SGTC_3184 9108758 49.47 µM 1.00115097846031 0.145164765391952 no 531 0.158376911115004 185 902885 SGTC_1033 k072-0102 21.3 µM 0.996705855798081 0.14623527866079 no 532 0.159453653247159 189 5965931 SGTC_183 3914-0051 30.55 µM 0.996186031434969 0.146360812675 no 533 0.159579882560337 159 1596232 SGTC_208 k072-0098 12.366 µM 0.995940579167514 0.146420112853118 no 534 0.159639508631325 192 5948901 SGTC_1065 prochlorperazine maleate 2.48 µM 0.994542531999271 0.146758182396236 no 535 0.159979404822551 203 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1739 st037196 92.5 µM 0.989434534716386 0.147997824926023 no 536 0.161225292451078 161 612214 SGTC_1066 ketoconazole 628 nM 0.986653305888387 0.148675730460202 no 537 0.161906314170042 200 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2762 leflunomide 42.06 µM 0.986424501538449 0.148731592216372 no 538 0.161962423338722 210 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_851 0394-0702 453 µM 0.98627432800513 0.148768264167092 no 539 0.161999256935955 205 762646 SGTC_1267 0828-0272 9.49 µM 0.985072555541662 0.149061951269204 no 540 0.162294216476745 186 745334 SGTC_1621 st003705 32.4 µM 0.983776354088369 0.149379148599741 no 541 0.162612744041944 182 24207032 SGTC_1970 st070122 35.8 µM 0.982808472408373 0.149616295459651 no 542 0.162850855608035 207 102928 SGTC_2541 muurolladie-3-one 83.07 µM 0.981576640958144 0.149918477464612 no 543 0.163154230006191 218 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2749 bexarotene 57.39 µM 0.980036408801897 0.150296885841251 no 544 0.163534073450158 187 82146 An retinoic acid receptor inhibitor. SGTC_3273 9137859 49.47 µM 0.979963564627403 0.150314798143351 no 545 0.163552052083989 221 2377234 SGTC_549 1661-1316 519 µM 0.978443052329381 0.150689015191607 no 546 0.163927621943696 210 2857282 SGTC_38 0929-0051 58.268 µM 0.975133623010385 0.151505649899753 no 547 0.164746991130547 191 1379719 SGTC_1286 0929-0070 131 µM 0.973342372085016 0.151948883968873 no 548 0.165191584957888 194 1420408 SGTC_1600 coumarin 106 71.1 µM 0.971688388585061 0.152358916192172 no 549 0.165602797525861 197 100336 A hepatotoxic, DNA x-linker. SGTC_3038 9091290 49.47 µM 0.971463403448116 0.152414748021432 no 550 0.165658784325814 181 25236843 SGTC_2626 ethyl orsellinate 100 µM 0.97100566205401 0.152528382056438 no 551 0.165772729521186 199 75653 A natural product. SGTC_391 gliotoxin 8.33 µM 0.969447996062555 0.152915492775281 no 552 0.166160857540352 187 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1116 jasmonic acid  1.58368 µM 0.96610438005178 0.153748645424751 no 553 0.16699597651597 191 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_992 3909-8734 162 µM 0.965895862116763 0.153800702681972 no 554 0.167048146557157 178 4288319 SGTC_2888 9058547 12.99 µM 0.965188650603826 0.1539773474731 no 555 0.167225165249202 156 16476514 SGTC_2006 4011487 200 µM 0.962971119457478 0.154532104653006 no 556 0.16778100842679 192 45595294 SGTC_2674 ligustilide 100 µM 0.961252267302207 0.154963015646287 no 557 0.168212670911642 196 5319022 A signalling regulator. SGTC_3120 9124077 49.47 µM 0.958336430475873 0.155695820263348 no 558 0.16894656958825 206 18774327 YGL155W CDC43 SGTC_702 1488-0190 94 µM 0.95733841656023 0.155947164044778 no 559 0.169198235489244 159 949357 SGTC_2397 5161689 200 µM 0.957078251254175 0.156012729030526 no 560 0.169263880052997 191 2259942 SGTC_1676 st018489 23.4 µM 0.956751201265945 0.156095175582412 no 561 0.16934642406238 183 3696235 SGTC_1837 st055472 66.5 µM 0.955634289330753 0.156376956106189 no 562 0.169628515745275 178 676091 SGTC_2223 6903751 107.57 µM 0.950891065515244 0.157577332058864 no 563 0.170829838865436 197 5598863 SGTC_1708 st033234 31.827 µM 0.94648422711895 0.15869798968864 no 564 0.171950831727007 185 674664 SGTC_2233 sulbentine 40.3845 µM 0.945150193904113 0.159038261714205 no 565 0.172291101409147 212 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_662 k832-1615 104 µM 0.944623255798018 0.159172799487177 no 566 0.172425624935391 194 5878478 SGTC_2219 9098279 200 µM 0.942780693628457 0.159643828156458 no 567 0.172896544407971 160 902349 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.941816824419997 0.159890592647324 no 568 0.173143214947046 199 804 An inhibitor of viral and cellular DNA polymerases. SGTC_670 4204-0025 119 µM 0.939741233821039 0.160422820550025 no 569 0.173675154506862 181 719039 SGTC_1417 3966-0327 90.4 µM 0.939524030225482 0.160478583245879 no 570 0.17373088023061 194 651118 SGTC_540 1187-0821 17.3 µM 0.939418817403427 0.160505599094041 no 571 0.173757877706178 210 847520 SGTC_2656 pseudo-anisatin 100 µM 0.938612164026792 0.160712824887535 no 572 0.17396495258738 215 6708809 A neurotoxin. SGTC_2979 9012552 45.46 µM 0.938293319666893 0.160794782793051 no 573 0.174046845936127 220 17100905 SGTC_1927 st060202 13.8 µM 0.937446869487749 0.161012492420629 no 574 0.174264370689088 203 688887 SGTC_652 0437-0092 114 µM 0.935219760658882 0.161586230307221 no 575 0.174837528411927 192 3091274 SGTC_1559 coumarin 343 70.1 µM 0.934347129954461 0.161811396515502 no 576 0.175062430212567 192 108770 A hepatotoxic, DNA x-linker. SGTC_1907 st060210 83.7 µM 0.934302618663926 0.161822887308219 no 577 0.175073906958074 211 688793 SGTC_803 4488-1585 147 µM 0.933633212987549 0.161995761561961 no 578 0.17524656339376 185 747204 SGTC_1895 st058434 18.3 µM 0.931935051418217 0.162434851848911 no 579 0.175685045869809 217 5393175 SGTC_902 1120-0002 2.07 µM 0.931500822565804 0.162547253783237 no 580 0.175797279649387 206 3280475 SGTC_2263 7948595 193.29 µM 0.930818302638202 0.162724029152963 no 581 0.175973780222468 188 2971371 SGTC_2968 9090663 33.37 µM 0.930096474293529 0.162911121562236 no 582 0.176160568047815 237 25236811 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.929253653989155 0.16312975108779 no 583 0.176378823761419 191 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2893 9048488 25.97 µM 0.927677225235134 0.163539191975595 no 584 0.176787512853821 195 6467338 SGTC_111 0083-0039 52.457 µM 0.927637563672235 0.163549501747435 no 585 0.176797802826305 169 759313 SGTC_940 3232-1287 54.8 µM 0.926994508719931 0.163716718699829 no 586 0.176964692695979 194 1585493 YIL048W NEO1 SGTC_1304 1165-0502 251 µM 0.925647822474074 0.164067264034752 no 587 0.177314516015737 204 767425 SGTC_3325 9138760 55.175 µM 0.924819125995705 0.164283217330972 no 588 0.177530000073739 183 43844959 SGTC_1344 1488-0097 29.1 µM 0.923415795387222 0.164649336943386 no 589 0.177895281691116 223 747966 SGTC_1937 st074714 47.2 µM 0.922239130291474 0.164956728201284 no 590 0.178201928222702 174 17250970 SGTC_1816 st051957 91.6 µM 0.922069752159322 0.165001007016402 no 591 0.178246096673164 196 674121 SGTC_880 0833-0487 87.2 µM 0.921745430754859 0.165085812560643 no 592 0.178330688671153 214 76075 SGTC_1713 st033146 12.748 µM 0.921466219401729 0.165158845052136 no 593 0.178403534979091 187 674619 SGTC_2845 9003024 42.97 µM 0.917273154929049 0.166258127252417 no 594 0.179499760447719 194 2990173 SGTC_1482 3346-2049 8.48 µM 0.917216588137633 0.166272989418329 no 595 0.179514578030161 185 3826804 SGTC_290 2043-6722 48.1 µM 0.915025731999395 0.166849267604593 no 596 0.180089060809506 199 773758 YLR208W SEC13 SGTC_2012 4023501 200 µM 0.914838237252156 0.166898645608905 no 597 0.180138278938376 225 3477460 SGTC_1817 st052116 64.4 µM 0.912295460975974 0.167569233455905 no 598 0.180806601553387 173 4361398 SGTC_2645 abamectin 100 µM 0.909639021611814 0.168271647912516 no 599 0.181506456209656 195 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_587 k089-0003 57 µM 0.909282894122409 0.168365958745576 no 600 0.181600408831474 192 9659696 SGTC_1121 fusaric acid 630.51 nM 0.908562072960575 0.168556952951783 no 601 0.181790667105707 179 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2832 7992762 51.95 µM 0.908191826352448 0.168655110408244 no 602 0.181888440883125 209 2985177 SGTC_2815 7968870 71.43 µM 0.907326692596844 0.168884612430356 no 603 0.182117031373358 193 2977326 YHR190W ERG9 SGTC_934 2950-0684 338 µM 0.905789034845965 0.169293016069398 no 604 0.182523762955981 218 1121253 SGTC_2322 7413319 38.22 µM 0.901923855129584 0.170322409265493 no 605 0.183548659111384 210 1840400 SGTC_2395 5646831 180.19 µM 0.901813485369009 0.170351862229799 no 606 0.183577977476223 210 6808628 SGTC_2718 lomofungin 53.02 µM 0.89961448661336 0.170939360793819 no 607 0.184162722567683 213 5351222 A RNA synthesis inhibitor. SGTC_3138 9097216 49.47 µM 0.897530463120193 0.171497336736631 no 608 0.184717962794704 233 25237486 SGTC_1636 st007707 68.9 µM 0.895967559827913 0.171916550947795 no 609 0.185135044653849 220 403051 SGTC_509 pifithrin 175 µM 0.895320391092578 0.172090331035018 no 610 0.185307921497566 229 4817 A p53 inhibitor. SGTC_1625 st003711 30.1 µM 0.894481238193315 0.172315830289876 no 611 0.185532231863863 203 24207034 YER133W GLC7 SGTC_1690 st023502 41.2 µM 0.893782777447438 0.172503666086578 no 612 0.185719062855171 208 24207482 SGTC_3123 9126162 49.47 µM 0.892229528427098 0.172921846436103 no 613 0.186134959013654 209 25239884 SGTC_3338 9144300 39.5675 µM 0.89165051518056 0.173077898983634 no 614 0.186290142518409 176 4901274 SGTC_198 3454-2873 16.191 µM 0.891394409000433 0.17314695195453 no 615 0.18635880805624 220 710957 SGTC_645 0845-0943 5.41 µM 0.887813722916597 0.174114236332072 no 616 0.187320479985698 196 1885106 SGTC_23 0213-0011 39.996 µM 0.886268596991851 0.174532694543087 no 617 0.187736403393133 216 627608 SGTC_2073 5212005 126 µM 0.88450246717285 0.175011787648324 no 618 0.188212515600948 225 691789 SGTC_1940 st075990 51.1 µM 0.884186524586095 0.175097580412687 no 619 0.188297765708842 227 1084979 SGTC_535 2293-4129 48.2 µM 0.882488351551963 0.175559168492188 no 620 0.188756388098963 241 396118 YIL048W NEO1 SGTC_545 4218-0007 221 µM 0.882383910785552 0.175587582158522 no 621 0.188784616674618 224 2840508 SGTC_530 4358-1714 28 µM 0.882266394809041 0.175619556489453 no 622 0.188816382369294 219 1564641 SGTC_3220 9131269 49.47 µM 0.881908637841327 0.175716919494677 no 623 0.188913107781975 229 17722206 SGTC_1731 st035964 63 µM 0.881330247521601 0.175874399844851 no 624 0.189069549569681 218 6739575 SGTC_2824 7998404 51.95 µM 0.880666084633169 0.176055344007775 no 625 0.189249289326929 208 837851 SGTC_1953 st076800 12.1 µM 0.879530186920401 0.17636508038278 no 626 0.189556936518356 214 297591 SGTC_24 0417-1663 219 µM 0.877314668849145 0.176970198763474 no 627 0.190157873447913 217 4329390 SGTC_2167 5876490 200 µM 0.876921669476397 0.177077674445971 no 628 0.190264592675009 219 686534 SGTC_3196 9111891 49.47 µM 0.875655216853338 0.17742429862843 no 629 0.190608748933639 228 18891510 SGTC_1014 4130-3005 69.3 µM 0.875274724702462 0.177528521779473 no 630 0.19071222160743 206 743608 SGTC_1175 0741-0056 27.6 µM 0.875044179535406 0.177591690745072 no 631 0.190774933821393 219 765927 SGTC_1350 1495-0454 146 µM 0.874060000636262 0.177861513512428 no 632 0.191042789538563 210 1069057 SGTC_2329 6138490 200 µM 0.873208872170317 0.178095067518454 no 633 0.19127461991574 206 720019 SGTC_3347 9188721 44.724 µM 0.87244018499219 0.178306165290749 no 634 0.191484143064463 242 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1519 esterone 74 µM 0.869905484154139 0.179003364351668 no 635 0.192176029094015 212 698 A steroid. SGTC_2439 5492030 7.2 µM 0.869320002684537 0.179164651415433 no 636 0.192336062540712 211 5722370 SGTC_2781 5567276 71.43 µM 0.868283320738822 0.179450458273495 no 637 0.192619625378074 220 2853274 SGTC_571 k831-0106 44.2 µM 0.866804939483757 0.179858534420976 no 638 0.193024447618013 226 4783639 SGTC_727 3032-0951 202 µM 0.865471214946314 0.180227180805454 no 639 0.193390104193792 208 3652836 SGTC_774 k060-0086 136 µM 0.861862538261069 0.181227007638575 no 640 0.194381582935307 213 5911235 SGTC_1203 3992-3522 103 µM 0.860799694234939 0.181522142208905 no 641 0.194674186726796 234 5322312 SGTC_2610 ononetin 44.17 µM 0.860510528419363 0.181602490901187 no 642 0.194753841195215 210 259632 SGTC_1681 tripelennamine 100 µM 0.860265077332075 0.181670710317475 no 643 0.194821469430038 193 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.858793836690929 0.182079955435447 no 644 0.195227134268198 242 5282309 SGTC_1623 st003709 20.3 µM 0.858189367304351 0.182248263532949 no 645 0.195393953131632 227 16192618 SGTC_2904 7225135 42.03 µM 0.85665572019162 0.18267572743558 no 646 0.195817590846191 255 4446116 SGTC_2687 chenodiol 100 µM 0.854717942877543 0.183216726422242 no 647 0.196353657404278 211 5702181 A cholesterol synthesis inhibitor. SGTC_2407 paclitaxel 400 µM 0.85414083407533 0.183378039645814 no 648 0.196513480489672 223 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2586 curcumin 80 µM 0.852133396028273 0.183939847342202 no 649 0.197070029111222 213 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3159 9100096 49.47 µM 0.851683145200146 0.184066002909984 no 650 0.197194988955139 206 25236875 SGTC_1934 st074720 32.6 µM 0.85116957792665 0.184209964826186 no 651 0.197337579766537 219 17250992 SGTC_2677 mitomycin C 100 µM 0.849653609023609 0.184635326074007 no 652 0.197758848753946 240 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.849537685288585 0.184667877890572 no 653 0.197791084875235 203 5379071 SGTC_104 0074-0074 590.992 µM 0.849408572299871 0.18470413749873 no 654 0.19782699240696 195 3943124 SGTC_520 3584-0023 682 µM 0.847764321567755 0.185166289754807 no 655 0.19828461830496 225 1340790 SGTC_281 1672-3440 14.9 µM 0.846948154578182 0.185395957647952 no 656 0.198512010018351 219 6833000 SGTC_1262 0737-0114 49.6 µM 0.845916805240845 0.185686430259938 no 657 0.198799578417732 232 765919 SGTC_754 3474-0146 171 µM 0.845493912386454 0.185805616769558 no 658 0.198917565073971 223 24762078 SGTC_3175 9106517 49.47 µM 0.845417457350111 0.185827169629141 no 659 0.198938900451612 220 41468073 SGTC_2635 hydroquinidine 100 µM 0.844652854411289 0.186042798331245 no 660 0.199152344753459 203 442912 An experimental heart treatment. SGTC_2366 9070441 60.58 µM 0.84326214962029 0.186435393941747 no 661 0.199540923270522 208 6837235 SGTC_2348 9022543 33.42 µM 0.841537209899099 0.186923056381646 no 662 0.200023524260815 240 3162678 YDL140C RPO21 SGTC_594 1487-1584 10.8 µM 0.839504578584615 0.187498719155711 no 663 0.200593110485802 227 5013332 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.839092185408084 0.187615646837336 no 664 0.200708790488755 205 1241132 A phosphatase inhibitor. SGTC_1952 st077036 64.1 µM 0.8389291232867 0.187661892995913 no 665 0.200754541928836 209 2937007 SGTC_2371 9071574 200 µM 0.837979342483385 0.18793140092122 no 666 0.20102115273227 227 45596039 SGTC_248 streptozotocin 5.23457 mM 0.837420103218893 0.188090201273856 no 667 0.201178234809555 238 5300 DNA alkylating agent. SGTC_1879 gemcitabine 100 µM 0.836150865635439 0.188450918359491 no 668 0.201535017948901 232 60750 A nucleoside analog which inhibits DNA replication. SGTC_1652 st011932 78 µM 0.835889458395623 0.188525263197886 no 669 0.201608546671049 227 1551076 SGTC_2370 9071495 200 µM 0.83565339125514 0.188592416790456 no 670 0.201674961528415 229 21791103 SGTC_1910 st062352 60.4 µM 0.835216046988113 0.188716866287851 no 671 0.201798038083494 225 2245730 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.832466727773299 0.189500363868611 no 672 0.202572775568492 251 279621 SGTC_2432 5630864 12.22 µM 0.832414106716601 0.189515379247339 no 673 0.202587621105764 234 5714970 SGTC_1892 st058411 7.36 µM 0.826978295191557 0.191070425785413 no 674 0.204124681894893 238 3934738 SGTC_6 0844-0013 19.835 µM 0.825933630409503 0.191370171574473 no 675 0.20442087098058 252 1584900 SGTC_3288 9119690 36.221 µM 0.824087877703539 0.191900477521161 no 676 0.204944813767607 238 17595618 YKL019W RAM2 SGTC_2187 6125751 200 µM 0.822636235037342 0.192318182417477 no 677 0.205357443214839 235 874498 SGTC_473 2-arachidonoylglycerol 10 µM 0.822593821313132 0.192330395167 no 678 0.20536950673117 232 5282280 An endocannabinoid. SGTC_989 1501-0895 10.3 µM 0.821501389455247 0.192645117057045 no 679 0.205680366488774 221 2830112 SGTC_1744 st037937 38.9 µM 0.821136048362753 0.192750439430304 no 680 0.205784389346743 238 1016152 SGTC_1009 4106-0057 9.87 µM 0.817955400476654 0.193668858352485 no 681 0.206691327195662 235 2928005 SGTC_3267 9137951 49.47 µM 0.817326687740452 0.193850715863187 no 682 0.20687087966545 242 16643986 SGTC_1695 st026914 34.495 µM 0.815168037526596 0.194475905293252 no 683 0.207488065351118 222 3289191 SGTC_397 arbidol 50 µM 0.814393432213785 0.194700545779646 no 684 0.207709799971089 224 131410 A RNA synthesis inhibitor. SGTC_1865 st057639 52.2 µM 0.814355703736586 0.194711491309215 no 685 0.207720603509067 246 688818 SGTC_53 0973-0023 39.979 µM 0.812492559317254 0.195252479710499 no 686 0.208254527183168 242 674768 SGTC_1513 0337-0559 19 µM 0.812080339586557 0.195372296389084 no 687 0.208372766817018 230 775073 SGTC_2196 6573537 42.6665 µM 0.81205394695193 0.195379969250458 no 688 0.208380338534517 245 2903087 SGTC_728 3030-5151 22.5 µM 0.810395671023338 0.195862429893309 no 689 0.208856402547698 234 3125388 SGTC_1374 2889-5571 141 µM 0.810062858011284 0.195959345915962 no 690 0.208952024894086 249 2853281 SGTC_1048 3161-0300 24.5 µM 0.809201358458154 0.196210351942192 no 691 0.209199666835444 213 2165101 SGTC_3063 1327-0034 4 µM 0.8089808150907 0.196274640662305 no 692 0.209263090790247 250 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2691 st077356 60.2 µM 0.802064482077962 0.198297236376772 no 693 0.211257829593263 237 2839272 SGTC_1715 st032160 10.2275 µM 0.800916303408702 0.198634220333148 no 694 0.21159005053088 213 5289825 SGTC_1050 3232-1156 69.3 µM 0.79906598123781 0.199178005640078 no 695 0.21212607700447 245 700529 SGTC_1119 parthenolide 318.541 nM 0.7984460453306 0.199360396993076 no 696 0.212305845875121 261 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1571 st070080 73.4 µM 0.798436392092834 0.199363237867224 no 697 0.21230864582259 231 4315245 SGTC_2601 securinine 100 µM 0.798216390709465 0.199427989201702 no 698 0.212372463663339 277 442872 A GABA receptor antagonist. SGTC_1045 1348-1485 165 µM 0.798097866320546 0.199462878831126 no 699 0.212406849777293 243 6810614 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.796667602811769 0.199884190363619 no 700 0.212822052048177 207 6312947 SGTC_700 3453-2283 142 µM 0.796468845048546 0.199942780597344 no 701 0.212879788447466 241 565664 SGTC_2659 sanguinarine 24.21 µM 0.796020478468762 0.200074988964616 no 702 0.213010066344621 246 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_168 3970-0862 530.542 µM 0.795886611508264 0.2001144720566 no 703 0.21304897189479 260 3135186 SGTC_3074 9116018 49.47 µM 0.79523401961357 0.200307016373994 no 704 0.213238693036051 282 17027303 SGTC_687 k029-0044 34.9 µM 0.795214335870007 0.200312825703201 no 705 0.213244417012891 215 5829338 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.794601265220583 0.200493813969862 no 706 0.213422741069268 235 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2377 9073351 62.6 µM 0.794089953789854 0.200644836371836 no 707 0.213571532844538 244 7337946 YHR072W ERG7 SGTC_2040 5100729 123 µM 0.792340851166776 0.201161972492148 no 708 0.214080979033014 243 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1239 0337-0584 35.4 µM 0.790104399235437 0.201824360383863 no 709 0.21473340044946 251 914301 YML130C ERO1 SGTC_1680 diphenhydramine 100 µM 0.78880815952587 0.202208875202307 no 710 0.215112069896374 236 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1248 0469-0687 58.6 µM 0.788458840853115 0.2023125715457 no 711 0.215214182348118 233 4017482 SGTC_1594 piperine 70.1 µM 0.787863701063843 0.202489313895186 no 712 0.215388217740772 229 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_401 neomycin 50 µM 0.78722127900244 0.202680201522001 no 713 0.215576171388476 220 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3320 9137005 35.139 µM 0.785488174659555 0.203195707768398 no 714 0.216083700482869 241 4908713 SGTC_667 1498-1044 59 µM 0.785468533745164 0.203201554375887 no 715 0.216089456168685 266 6739982 SGTC_1530 rhein 70.4 µM 0.784641122421686 0.203447945175225 no 716 0.21633200616363 256 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3110 9122132 49.47 µM 0.783829269491561 0.203689876065138 no 717 0.216570148426479 220 918317 SGTC_52 0329-0193 875 nM 0.783284499506418 0.20385231278548 no 718 0.21673003176681 254 3739292 SGTC_2089 5281248 129.67 µM 0.782516053667327 0.204081575243162 no 719 0.216955677252461 228 2737878 SGTC_792 4534-1957 155 µM 0.781522534288741 0.204378214961823 no 720 0.217247614224537 230 1717904 SGTC_1742 st038235 28.8875 µM 0.781268252055435 0.204454178429171 no 721 0.217322369283648 254 564103 YBR002C RER2 SGTC_2473 5854593 8.94 µM 0.78101054063475 0.204531183464727 no 722 0.217398147625319 248 2872951 SGTC_1453 4237-0541 195 µM 0.780585301394261 0.204658284102655 no 723 0.217523219766024 234 739892 SGTC_3145 9085516 49.47 µM 0.779888955091253 0.204866517936401 no 724 0.21772812007622 246 25236195 SGTC_1008 4106-0037 6 µM 0.779855965375276 0.204876386231627 no 725 0.217737830081397 263 2905394 SGTC_2962 9082311 13.18 µM 0.779521060976337 0.204976583010278 no 726 0.217836418075543 259 16459453 SGTC_3329 9141233 27.5565 µM 0.779151310967767 0.205087238734936 no 727 0.217945293697087 244 4909101 YNL103W MET4 SGTC_1206 3978-0017 132 µM 0.778798301008101 0.205192917757842 no 728 0.218049269360016 234 3873677 SGTC_453 enantio-paf c16 10 µM 0.777575622348343 0.205559195667836 no 729 0.21840961847385 273 13871343 A lipid and platelet activating factor SGTC_2361 9034121 116 µM 0.77551358318147 0.206177799448289 no 730 0.219018121140909 271 6496917 SGTC_576 1073-0113 22.7 µM 0.774764930331973 0.206402665210368 no 731 0.219239287774277 274 5439563 SGTC_2333 9017922 200 µM 0.774679559866121 0.206428316355226 no 732 0.219264516024218 250 3163164 SGTC_2229 7354935 190 µM 0.773713320613748 0.206718772561238 no 733 0.21955017047434 267 318112 SGTC_2345 9052315 157.45 µM 0.773670865538841 0.206731540310047 no 734 0.219562726594328 241 6469265 SGTC_2986 9022445 71.43 µM 0.77232933043179 0.207135227990397 no 735 0.219959698971912 250 6459286 SGTC_3280 9140961 49.47 µM 0.772308520214793 0.207141493761848 no 736 0.219965860145478 257 4901226 SGTC_2349 9023730 187.07 µM 0.771200543156469 0.207475257675847 no 737 0.220294036155091 250 4126287 SGTC_2767 sibutramine 71.45 µM 0.763471768130902 0.209812280111232 no 738 0.222591046518369 242 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1308 1187-1617 41.4 µM 0.762913437195319 0.209981705120852 no 739 0.222757510980851 249 2882570 SGTC_2835 9006588 71.43 µM 0.762745989833463 0.210032532535746 no 740 0.222807448665679 225 2345538 SGTC_2965 9082772 38.63 µM 0.762139266321923 0.210216759533451 no 741 0.222988444726421 187 16459634 SGTC_1354 1498-1681 81 µM 0.761858444429632 0.21030206109233 no 742 0.223072247069774 230 5754243 SGTC_1568 digitonin 820 nM 0.761547256158387 0.210396610381424 no 743 0.223165132235386 276 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1140 3229-1848 2.98 µM 0.760447053502482 0.210731088352894 no 744 0.223493703181724 252 2849525 SGTC_2856 9022925 19.48 µM 0.760379850879116 0.210751529053045 no 745 0.223513781879533 248 4944862 SGTC_937 3122-0005 46.7 µM 0.759926601460629 0.210889422129066 no 746 0.223649229847482 255 759535 SGTC_1040 k898-0338 155 µM 0.759863783985535 0.210908537402215 no 747 0.223668005752792 264 20969351 SGTC_1562 morin hydrate 59.1 µM 0.759314876788333 0.211075612343476 no 748 0.223832110163118 249 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_551 k048-0028 34.9 µM 0.757230641779339 0.211710712459411 no 749 0.22445584776235 258 6836383 SGTC_885 0865-0106 16.8 µM 0.757067911677962 0.211760345977091 no 750 0.224504588586704 254 2793380 SGTC_1782 st039423 80.636 µM 0.755733703660477 0.212167542989641 no 751 0.224904436194339 246 2068169 SGTC_1214 0358-0031 63.7 µM 0.755528863336962 0.212230100263502 no 752 0.224965860334105 257 4301366 SGTC_3268 9137683 49.47 µM 0.753642723785741 0.212806624934538 no 753 0.225531891418842 303 1953228 SGTC_72 0744-0168 198.391 µM 0.751111457635042 0.213581776440334 no 754 0.226292790411267 268 677577 SGTC_1774 st048371 48.465 µM 0.750905509467292 0.213644916389658 no 755 0.226354762191204 271 4242727 SGTC_2147 5545932 89.7195 µM 0.75017402779235 0.213869263203524 no 756 0.226574949514528 271 797404 SGTC_1955 wogonin 32.4 µM 0.748192583002014 0.214477664682783 no 757 0.227172002064047 239 5281703 A flavanone. SGTC_722 3534-0461 190 µM 0.747956472023278 0.214550229462573 no 758 0.227243206538493 243 658262 SGTC_1385 3091-4834 14.1 µM 0.746831718915461 0.214896099484279 no 759 0.227582573263514 234 4072814 SGTC_964 1287-0107 19.4 µM 0.746737349134428 0.214925133619145 no 760 0.227611060005974 230 51516812 YPR165W RHO1 SGTC_2877 9040724 71.43 µM 0.742193280151913 0.216325871646191 no 761 0.228985119706794 243 6463895 SGTC_378 3970-0959 8.33 µM 0.741912976904041 0.216412449592514 no 762 0.229070031423332 261 6615653 SGTC_553 k007-0256 45.7 µM 0.741491660499964 0.21654262033224 no 763 0.229197693200868 247 6287000 SGTC_249 wiskostatin 11.211 µM 0.740508517306837 0.216846550300688 no 764 0.229495747494052 242 2775510 A n-wasp and actin depolymerizer. SGTC_2043 5101342 149 µM 0.740411542550432 0.216876542540739 no 765 0.229525158578933 271 678451 SGTC_1565 sinapyl alcohol 95.1 µM 0.738797457855538 0.217376096804817 no 766 0.230014997856271 258 5280507 A phenol propionate derived from cinnamic acid. SGTC_2821 7996764 71.43 µM 0.738478145733014 0.217475001589388 no 767 0.230111971344962 220 2987135 SGTC_1518 st038567 90.8 µM 0.737593840886233 0.217749044625274 no 768 0.230380649641628 282 77966 SGTC_1921 5740136 50 µM 0.737573895636517 0.217755227886079 no 769 0.23038671162776 251 1774243 SGTC_1428 4049-0204 61.7 µM 0.73720012190028 0.217871120851489 no 770 0.230500329667568 269 X1428 SGTC_961 1252-1571 372 µM 0.734373785342303 0.218748610612071 no 771 0.231360479624999 271 6813498 SGTC_1844 rapamycin 4 nM 0.731070920678479 0.219776620099309 no 772 0.232367917554843 261 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_337 1315-0038 354 µM 0.729714600212589 0.220199573871839 no 773 0.232782327384606 259 1626437 SGTC_2067 5224629 34.075 µM 0.728323034185222 0.220634003320968 no 774 0.23320793262096 260 2835000 SGTC_1081 sertraline 6 µM 0.724066549714713 0.221965867928468 no 775 0.234512439697099 264 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2860 9025725 38.96 µM 0.722839056114177 0.222350804854593 no 776 0.234889384627697 245 40546248 SGTC_1956 st077085 54 µM 0.720692864163276 0.223024755942405 no 777 0.235549251884896 285 24208685 SGTC_2890 9046729 58.44 µM 0.719032220119567 0.22354703177613 no 778 0.236060533812705 266 903329 SGTC_427 1354-0053 47.3 µM 0.717681541618408 0.223972335341099 no 779 0.236476833525578 266 6813657 SGTC_1506 4226-2149 212 µM 0.717081871257092 0.224161307664506 no 780 0.236661790515213 263 991114 SGTC_2597 laccaic acid a 100 µM 0.714298055376559 0.225039748125583 no 781 0.237521447222424 258 5491415 A textile dye. SGTC_3189 9110682 49.47 µM 0.713612326919154 0.225256430610081 no 782 0.237733466491918 261 17122418 SGTC_1635 st007035 42.4 µM 0.710680648915793 0.226184139237589 no 783 0.238641076895563 256 3716403 SGTC_2148 5546263 113.568 µM 0.710101912359428 0.226367531126052 no 784 0.238820470258037 252 792097 SGTC_2180 6301957 200 µM 0.708843709325733 0.226766524142912 no 785 0.239210735032499 260 845462 SGTC_1114 scopoletin 1.73284 µM 0.706949624188562 0.227367911497217 no 786 0.239798891945146 264 5280460 A coumarin with genotoxic properties. SGTC_704 1310-0270 142 µM 0.706246514915083 0.227591382852487 no 787 0.240017424142299 285 5718033 SGTC_1112 tnp00069 1.16933 µM 0.706162563855155 0.227618073535053 no 788 0.240043524083202 255 145826 SGTC_93 0109-0045 59.227 µM 0.704879242795516 0.228026300981169 no 789 0.240442694379847 274 88733 SGTC_2118 5526350 200 µM 0.70444648001977 0.228164056628159 no 790 0.240577384442206 269 743594 SGTC_529 4076-0302 30.3 µM 0.70422191821283 0.228235556851696 no 791 0.240647291674649 273 5816522 SGTC_2945 9067681 61.76 µM 0.702002334205708 0.228942947006118 no 792 0.241338853880648 300 16456930 SGTC_1404 3909-7820 48.3 µM 0.701829987380579 0.228997926043933 no 793 0.241392597620347 262 23741373 SGTC_2350 9023895 38.85 µM 0.701813547188361 0.229003170890448 no 794 0.241397724584249 265 2997209 SGTC_2947 9072639 7.68 µM 0.700674618752233 0.22936668254275 no 795 0.24175304961082 289 16488146 SGTC_1786 berberine 21.6 µM 0.700581483458635 0.229396422822841 no 796 0.241782118684226 277 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1606 st000094 49.2 µM 0.699201517461241 0.229837331462283 no 797 0.24221305120279 248 1242210 SGTC_1462 k081-0014 26.5 µM 0.699138086454594 0.229857609505037 no 798 0.242232869290996 241 3270634 SGTC_963 1269-2853 151 µM 0.698359724200094 0.230106523026556 no 799 0.242476128718338 253 3668223 SGTC_2226 7298446 200 µM 0.697828932116883 0.230276352198079 no 800 0.242642091574091 272 3283010 SGTC_1419 3993-2473 62.6 µM 0.696384047188787 0.230739004172476 no 801 0.243094175417077 284 704026 SGTC_732 3970-1727 52.7 µM 0.694356868512548 0.231388980905777 no 802 0.243729217730653 280 1275699 SGTC_1256 0570-0116 285 µM 0.693751963221047 0.23158313002918 no 803 0.243918886189706 271 410638 SGTC_921 1561-0023 372 µM 0.693710178418718 0.231596544542868 no 804 0.243931990782454 274 24050882 SGTC_897 1000-0139 31.4 µM 0.692627247728682 0.231944357583315 no 805 0.244271753082584 275 6151020 SGTC_1331 1472-0049 76.2 µM 0.692591706628221 0.23195577751515 no 806 0.244282908188348 286 24051409 SGTC_2704 st078022 71.1 µM 0.692506257485901 0.231983234991295 no 807 0.24430972880293 276 54697681 SGTC_585 0kpi-0023 191 µM 0.692098091784033 0.232114416335696 no 808 0.244437864974222 246 64601 SGTC_1141 3253-0389 52.6 µM 0.691393027632476 0.232341115813859 no 809 0.244659292267842 281 5402031 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.690553083944827 0.232611343843538 no 810 0.244923219761608 291 442882 SGTC_965 1291-5240 308 µM 0.689893460326286 0.23282368143684 no 811 0.245130594351733 294 2834598 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.686850034937196 0.233804775422943 no 812 0.246088617906459 287 688751 SGTC_2189 6047310 154.431 µM 0.68506836828029 0.23438018407692 no 813 0.246650389816191 273 711535 SGTC_348 k064-0012 10.7 µM 0.683471950860542 0.234896429442675 no 814 0.247154334178481 280 5066323 SGTC_1818 st052136 56.3 µM 0.682070350135674 0.235350193050728 no 815 0.247597233924942 268 674169 SGTC_3158 9100007 49.47 µM 0.68196465111128 0.235384432370338 no 816 0.247630651541201 271 19297233 SGTC_2434 5670830 169.91 µM 0.681928835945708 0.235396034680023 no 817 0.247641975346907 294 1549830 SGTC_2546 rhodinyl acetate 100 µM 0.681739298705745 0.23545744045389 no 818 0.247701906601016 268 6708682 SGTC_745 0469-0705 296 µM 0.681024283096963 0.235689168873427 no 819 0.247928062652847 298 3486736 SGTC_1647 st011722 22.4 µM 0.678853001114106 0.236393626932715 no 820 0.24861550373712 270 2854783 SGTC_474 dl-dihydrosphingosine 5 µM 0.678603500963976 0.236474649786236 no 821 0.248694561990313 248 3058739 A sphingolipid protein kinase C inhibitor. SGTC_898 1000-0849 28.3 µM 0.677779762786139 0.23674225959794 no 822 0.248955672112083 287 6751807 SGTC_49 0717-0965 32.132 µM 0.676867341253529 0.237038874506362 no 823 0.249245063466926 299 5889349 YGL099W LSG1 SGTC_219 mitoxanthrone 164.414 µM 0.675617259675699 0.237445589137047 no 824 0.249641840184183 295 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_159 3970-0959 50 µM 0.674857960236657 0.237692814461848 no 825 0.24988300600648 271 6615653 SGTC_44 0929-0055 61.211 µM 0.674698883346904 0.237744627244551 no 826 0.249933547071556 269 1379590 SGTC_423 5-fluorouracil 457 µM 0.674612368126693 0.237772808635504 no 827 0.249961036505609 282 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_213 1246-0773 967 nM 0.673872351299249 0.238013935908428 no 828 0.250196235749264 276 6251622 SGTC_2650 prasterone 100 µM 0.672285835673074 0.23853133799146 no 829 0.250700872637185 258 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_912 3474-0017 2.18 µM 0.67103930667451 0.238938293533977 no 830 0.251097744828724 287 3360550 SGTC_724 3910-0327 137 µM 0.670392831350995 0.239149498378551 no 831 0.251303701633805 299 2885483 SGTC_262 fenpropimorph 62.5 µM 0.670045184209769 0.239263117600956 no 832 0.251414493427584 297 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.669943417398422 0.239296382956061 no 833 0.251446930413675 272 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_276 colchicine 750 µM 0.669878856996473 0.239317487655733 no 834 0.251467509436567 292 2833 A microtubule depolymerizer. SGTC_1991 st073000 8.92 µM 0.66953728786455 0.239429163017 no 835 0.251576401495612 292 4301969 YIL048W NEO1 SGTC_982 1491-0518 27.5 µM 0.668744485425086 0.239688477878183 no 836 0.251829242474528 287 3091256 SGTC_1435 4092-0789 56.7 µM 0.666249756201253 0.240505468831173 no 837 0.252625737269651 285 2248285 SGTC_182 3448-4371 550.524 µM 0.665466751447796 0.240762204889135 no 838 0.252876001332616 248 3491403 SGTC_3294 9122953 26.2835 µM 0.664821285353809 0.240973956080314 no 839 0.253082403360107 287 16459826 SGTC_1213 1315-0166 115 µM 0.66306452288631 0.241550791080029 no 840 0.25364461546632 273 768401 SGTC_1764 st044502 93.5 µM 0.661840839500781 0.241953031564698 no 841 0.254036614906639 277 8407 SGTC_1660 st012960 28.1 µM 0.661177735770284 0.242171153998163 no 842 0.254249168810596 289 24207266 SGTC_2984 9022109 38.96 µM 0.659896887714852 0.242592779922085 no 843 0.254660000797116 311 6459207 SGTC_1277 0873-0036 22 µM 0.656439126222245 0.243732978318563 no 844 0.255770811413657 284 5965735 SGTC_1001 4048-4355 44.4 µM 0.656163712316222 0.243823920405395 no 845 0.255859397142219 284 21824233 SGTC_1951 sophoraflavanone G 9.2 µM 0.656132186637603 0.243834331399996 no 846 0.255869538265902 280 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2787 5284540 71.43 µM 0.65593592712189 0.243899149254633 no 847 0.255932675392091 291 736958 SGTC_410 α-linolenic acid 100 µM 0.654910376653398 0.24423800493336 no 848 0.256262729458166 275 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3202 9113761 49.47 µM 0.654594287235907 0.244342496276034 no 849 0.256364501588379 286 4798415 SGTC_1909 st060837 51.5 µM 0.654273070820067 0.244448707155478 no 850 0.256467946046569 288 678937 SGTC_815 1582-0027 36.9 µM 0.65366395691843 0.244650180230294 no 851 0.25666416464389 299 3128206 SGTC_2836 9010338 19.48 µM 0.653268475139519 0.244781039307507 no 852 0.256791606104977 268 2994051 SGTC_3304 9125678 46.087 µM 0.652622295118081 0.244994931779896 no 853 0.256999904314956 289 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2489 cantharidin 73.42 µM 0.651738519245179 0.245287633744033 no 854 0.25728493456051 286 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1118 chelidonine 707.474 nM 0.651222045678319 0.245458774088736 no 855 0.25745158064199 282 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1446 4239-0190 62 µM 0.650816196397271 0.245593302618296 no 856 0.257582571872278 284 1340085 SGTC_1707 st032323 6.317 µM 0.650593024346277 0.245667295247992 no 857 0.257654617254113 277 3132057 YMR211W DML1 SGTC_356 1634-0012 32.5 µM 0.649688071012069 0.245967454920664 no 858 0.257946865459363 300 735457 SGTC_866 0495-0101 262 µM 0.647695890672753 0.246628924586472 no 859 0.258590831307492 278 635694 SGTC_692 k241-0027 77.8 µM 0.646949256407417 0.246877077050467 no 860 0.258832392700658 279 3600480 SGTC_2784 7567673 72.73 µM 0.645594287065427 0.247327757770084 no 861 0.259271069064062 285 3471247 SGTC_2683 piperine 63.03 µM 0.645448036722616 0.247376428852039 no 862 0.259318441119692 294 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_726 3448-4391 34.2 µM 0.643987165422809 0.247862877351243 no 863 0.259791878350552 298 1356692 SGTC_2347 9049783 174.81 µM 0.642664727675888 0.248303669459622 no 864 0.260220836507399 316 6467988 YPL169C MEX67 SGTC_1226 3909-7979 35.4 µM 0.641852840707936 0.248574492784874 no 865 0.260484368402891 295 6615510 SGTC_1430 4049-0248 69.1 µM 0.640351469818244 0.249075723396181 no 866 0.260972062969063 297 22774488 SGTC_2880 9042983 58.44 µM 0.639428610348674 0.24938408538402 no 867 0.261272070861689 302 6464714 SGTC_2679 rapamycin 1 nM 0.638855937981591 0.249575538698055 no 868 0.261458327184263 264 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_132 0417-1715 25.805 µM 0.638302961680076 0.249760481385759 no 869 0.261638242225903 301 6769098 SGTC_33 0986-0033 35.816 µM 0.637200234742225 0.250129505081206 no 870 0.26199721240257 265 2848082 SGTC_1501 4491-0275 38.4 µM 0.637140035270242 0.250149658945004 no 871 0.26201681637376 292 5104718 SGTC_1766 st045414 44.774 µM 0.636072061557666 0.250507343367265 no 872 0.262364727204563 315 253960 SGTC_1010 4112-3296 15.2 µM 0.635962364078498 0.25054409845177 no 873 0.262400476440863 289 704384 SGTC_1229 0139-0193 12.2 µM 0.633860210769183 0.251248994665128 no 874 0.263086027286416 304 3090752 SGTC_329 k048-0121 21.3 µM 0.63276526459654 0.251616568082355 no 875 0.263443471537396 284 6832902 SGTC_1023 4482-3888 16 µM 0.632700503870447 0.251638317151124 no 876 0.263464620383708 306 3303168 SGTC_1005 4092-0690 4.4 µM 0.632638505205056 0.251659139547152 no 877 0.263484868038509 307 1529343 SGTC_3192 9110362 49.47 µM 0.632571847995477 0.251681527541225 no 878 0.263506637976426 314 16649480 SGTC_503 tyrphostin 8 294 µM 0.63141312330307 0.252070873583058 no 879 0.263885218751484 317 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1908 st060353 56.5 µM 0.629958270412697 0.252560171992295 no 880 0.264360943419241 312 4227716 SGTC_2816 7982706 58.44 µM 0.629575254038467 0.252689071818232 no 881 0.264486259114629 298 2981853 SGTC_76 0433-0009 400.328 µM 0.628999407386895 0.252882931673266 no 882 0.264674722092078 331 2841569 SGTC_3051 9093778 49.47 µM 0.628927924768112 0.252907001891717 no 883 0.264698121673781 318 17217378 SGTC_2221 6807166 181.081 µM 0.628103355790028 0.253184744732996 no 884 0.264968117444162 275 674925 SGTC_2111 5486399 200 µM 0.626685413904894 0.253662730559492 no 885 0.265432733455092 280 689674 SGTC_1781 st038725 66.3 µM 0.626357471158548 0.253773346949998 no 886 0.265540249054136 295 4270275 YIL048W NEO1 SGTC_2246 7293507 91.5585 µM 0.624719732837743 0.254326141412183 no 887 0.26607750984668 288 887656 SGTC_1607 st000305 50.6 µM 0.624612891599199 0.254362226019534 no 888 0.266112578281969 313 5457690 SGTC_12 0849-0099 9.267 µM 0.623888986893832 0.25460678858704 no 889 0.266350246722931 297 6071388 SGTC_255 tunicamycin 200.472 nM 0.621937887478098 0.255266557063724 no 890 0.266991355467107 284 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_54 0159-0055 9 µM 0.621899746546465 0.255279463403305 no 891 0.267003895899126 322 3319099 SGTC_550 4123-0385 25.7 µM 0.62156272677079 0.255393520843771 no 892 0.267114718220307 291 5731123 SGTC_835 0312-0010 67.2 µM 0.619536215098455 0.256079913341754 no 893 0.267781585966401 306 1626196 SGTC_1410 3909-8106 77.9 µM 0.618776807183507 0.25633737729022 no 894 0.268031701546072 309 1039210 SGTC_2652 actinonin 100 µM 0.618165067865881 0.256544874858471 no 895 0.26823326707761 293 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1138 3761-0006 1.03 µM 0.618031411382438 0.256590221817495 no 896 0.26827731647629 288 12061087 SGTC_2937 9044753 11.33 µM 0.617351828057554 0.256820855342783 no 897 0.26850134420637 291 6465530 YGL099W LSG1 SGTC_1534 6-azauridine 81.6 µM 0.617245378270996 0.256856991500295 no 898 0.268536444379748 298 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2225 6654152 15.4 µM 0.616951889113233 0.256956634998491 no 899 0.268633229842045 306 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1358 1509-0022 2.48 µM 0.61654446966811 0.257094992683712 no 900 0.268767615745365 309 3258434 SGTC_2581 avocatin a 64 µM 0.61592670867354 0.257304855234667 no 901 0.268971446486418 315 6710728 A skin care supplement. SGTC_2011 4012611 177 µM 0.615466562412771 0.257461231567523 no 902 0.269123322529932 298 2049887 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.614668276214338 0.257732638623546 no 903 0.269386907204756 296 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3174 9107204 49.47 µM 0.61442493408842 0.257815401348423 no 904 0.269467281633813 313 3938802 SGTC_1785 bathophenanthroline 24 µM 0.613278802512071 0.258205395823553 no 905 0.269846003502068 282 72812 An iron chelator. SGTC_1978 st071761 42 µM 0.612992108762613 0.258302996971064 no 906 0.269940778770352 290 5147680 SGTC_2191 5911152 200 µM 0.611928660910648 0.258665200846258 no 907 0.270292478993842 296 2875902 SGTC_2892 9047358 58.44 µM 0.611350339887865 0.258862283789177 no 908 0.270483835676707 304 6466771 SGTC_1364 1653-0028 37.6 µM 0.611235581696565 0.258901400858435 no 909 0.270521815275996 279 5718652 SGTC_3153 9100258 49.47 µM 0.609218523817621 0.259589444521193 no 910 0.271189801843992 317 25236848 SGTC_2826 7992541 19.48 µM 0.608393905180902 0.259871003874494 no 911 0.27146312640754 345 2985066 SGTC_1367 1812-0510 76.9 µM 0.608127562578678 0.259961978046711 no 912 0.271551436496874 277 1142582 YDR527W RBA50 SGTC_1575 cyproterone acetate 48 µM 0.60781320421273 0.260069374008368 no 913 0.271655685374935 325 9880 An androgen receptor antagonist and liver toxin. SGTC_1447 4239-0816 81.9 µM 0.60136539180423 0.26227721071162 no 914 0.273798322067384 296 1341554 SGTC_1209 2323-2347 50.3 µM 0.600169608927901 0.262687719224544 no 915 0.274196602758381 294 5412760 SGTC_1693 xanthone 101.9 µM 0.599448679919944 0.262935370628969 no 916 0.274436861544327 319 7020 An insecticide. SGTC_3018 9082602 49.47 µM 0.598651408747315 0.263209385790693 no 917 0.274702683257974 312 17332089 SGTC_2020 4017018 200 µM 0.59596119434222 0.264135064362972 no 918 0.275600575477064 318 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3317 9138495 8.753 µM 0.594188400418109 0.264745972020813 no 919 0.27619305507837 305 17020139 SGTC_1370 2001-0092 44.6 µM 0.593820268277997 0.264872920978732 no 920 0.276316165641473 308 790957 SGTC_2730 imipramine 71.33 µM 0.591436442039536 0.265695722518867 no 921 0.277114014571261 289 3696 A tricyclic antidepressant. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.590641430089678 0.265970416752817 no 922 0.277380349616164 299 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_834 0312-0008 75.7 µM 0.590424667133135 0.266045338108528 no 923 0.277452988561496 311 6385573 YIL048W NEO1 SGTC_2903 5923464 63.88 µM 0.589852138966676 0.266243276567922 no 924 0.277644891885382 302 2876576 SGTC_2469 5655019 90.81 µM 0.589684169822367 0.26630136218032 no 925 0.277701205060595 316 2788239 SGTC_750 4073-0104 132 µM 0.589610755770023 0.266326751596313 no 926 0.27772581953764 295 22330957 SGTC_705 1124-0212 310 µM 0.588365867959545 0.266757468324848 no 927 0.27814337129304 337 9554485 SGTC_1833 st055984 71 µM 0.587999029663743 0.26688445723801 no 928 0.278266472065305 307 676288 SGTC_1387 3342-1166 1.8 µM 0.587659493980375 0.267002021978476 no 929 0.278380434501867 305 3418228 SGTC_672 1441-0018 53.7 µM 0.587493861586126 0.267059381933616 no 930 0.278436035943533 291 251141 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.587403157844473 0.2670907960737 no 931 0.278466486741515 315 5377381 SGTC_3208 9114115 49.47 µM 0.585053891513881 0.267905085351686 no 932 0.279255740376413 320 650895 SGTC_1887 st057648 70.8 µM 0.584481132215974 0.268103801314311 no 933 0.279448327856273 321 688672 SGTC_893 0958-0369 48.9 µM 0.581677470893444 0.269077586708657 no 934 0.280391974682933 318 6819948 SGTC_2727 riluzole 51.77 µM 0.580964442766516 0.269325522951897 no 935 0.280632209126249 326 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2759 disulfiram 3.38 µM 0.579410893893511 0.269866123968764 no 936 0.281155977589745 301 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_977 1348-1378 135 µM 0.578342945607531 0.270238061413325 no 937 0.281516302728866 304 X977 SGTC_487 nimodipine 119 µM 0.57698677273384 0.270710748814729 no 938 0.281974195493947 303 4497 L-type voltage-gated calcium channels inhibitor SGTC_3303 9125618 40.5795 µM 0.576866472023792 0.270752698963156 no 939 0.282014830659074 313 22695467 SGTC_517 1365-0151 113 µM 0.576047472474067 0.271038379124107 no 940 0.282291547199306 306 768657 SGTC_22 0964-0034 14.468 µM 0.575895119807001 0.271091538756216 no 941 0.282343037219724 321 138402 SGTC_1843 st055809 45.5 µM 0.575270149433282 0.271309660853916 no 942 0.282554303222856 305 16413835 SGTC_806 3966-4455 5.86 µM 0.57521228293474 0.27132986137398 no 943 0.282573868351806 310 714982 SGTC_2252 omeprazole 400 µM 0.574518115601243 0.271572245509793 no 944 0.282808622667159 302 4594 A proton pump inhibitor. SGTC_780 0109-0199 192 µM 0.57443628623907 0.271600825174807 no 945 0.282836301987309 312 610414 SGTC_608 k048-0125 159 µM 0.573770191680723 0.27183352058522 no 946 0.283061661245043 300 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2120 5538279 151.968 µM 0.572050864270918 0.272434613536952 no 947 0.28364375795372 296 2058197 SGTC_2943 9068529 45.32 µM 0.571549154757533 0.27261014021423 no 948 0.283813725094342 331 3270634 SGTC_1208 2323-2347 50.3 µM 0.569801514260241 0.273222002788053 no 949 0.2844061641939 326 5412760 SGTC_2090 5301565 104.445 µM 0.569175586115122 0.273441310472146 no 950 0.284618493506701 324 2056344 SGTC_69 0096-0274 206.684 µM 0.567324341472334 0.274090444331731 no 951 0.285246921109649 336 6741392 SGTC_2165 5727197 32.143 µM 0.566547896073821 0.274362929233215 no 952 0.285510691631847 327 1361712 SGTC_3188 9110789 49.47 µM 0.564441069987456 0.275102969510513 no 953 0.286226997456622 322 849217 SGTC_3053 9095903 49.47 µM 0.563746545736515 0.275347142233011 no 954 0.28646331764625 357 17174018 SGTC_2398 5228213 48.84 µM 0.563236309045666 0.275526593218285 no 955 0.286636990761227 326 80771 YMR134W ERG29 SGTC_2288 7946289 167.31 µM 0.563122245478093 0.275566717405952 no 956 0.286675822266959 333 1246052 SGTC_511 blebbistatin 171 µM 0.562464753530748 0.27579805962041 no 957 0.286899705740599 323 3476986 A myosin inhibitor. SGTC_1425 4048-4433 7.33 µM 0.561532408178067 0.276126274075669 no 958 0.287217321877102 354 23734946 SGTC_504 lovastatin 124 µM 0.560465751972404 0.276502005118735 no 959 0.287580896819004 333 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_403 arphamenine a 50 µM 0.559803762466102 0.276735317783494 no 960 0.287806648510588 327 5487158 An arginine aminopeptidase inhibitor. SGTC_1790 st045711 43.5 µM 0.559263368591336 0.276925846563114 no 961 0.287990995689995 285 585119 SGTC_2340 7987427 183.45 µM 0.558476208411123 0.277203493572148 no 962 0.288259623143683 304 2239331 SGTC_137 0438-0332 85.389 µM 0.557988768937531 0.277375491389083 no 963 0.288426026688354 333 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_725 1497-0963 19 µM 0.556136228583894 0.278029654086091 no 964 0.289058865149987 321 3549977 SGTC_2735 sertaconazole 140 nM 0.555983294825833 0.278083691147239 no 965 0.289111137372444 344 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2858 9025781 8.96 µM 0.555502187053393 0.278253717430502 no 966 0.2892756073041 295 4894980 YPL153C RAD53 SGTC_869 0564-0080 44.1 µM 0.555469805362956 0.278265163128392 no 967 0.289286678782344 299 6843321 SGTC_671 0560-0003 407 µM 0.555288756508115 0.278329161252346 no 968 0.289348584051769 323 3238678 SGTC_2522 biochanin a 4.94 µM 0.552998889956138 0.279139214236659 no 969 0.290132085137545 326 5280373 A possible chelator. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.552652606697963 0.27926181355553 no 970 0.290250655957013 317 140250 A respiratory chain inhibitor. SGTC_2490 carminic acid 95.39 µM 0.552319578051319 0.279379744844802 no 971 0.290364709673502 290 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_685 1278-0033 54.9 µM 0.552169473202917 0.27943290751481 no 972 0.29041612357008 337 3590572 SGTC_2282 7944268 200 µM 0.551411885770289 0.279701297389733 no 973 0.290675677350256 318 2970414 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.549609764398973 0.280340235698011 no 974 0.291293530049179 314 279621 SGTC_3198 9112019 49.47 µM 0.547493079934261 0.281091603154917 no 975 0.292020011693376 366 45595555 SGTC_3066 9117245 49.47 µM 0.547473295213203 0.281098630798399 no 976 0.292026806119052 299 17176980 SGTC_1139 k015-0024 46.9 µM 0.547219974891585 0.281188619091915 no 977 0.292113807333413 322 2766652 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.546434350939621 0.281467788811494 no 978 0.292383701449933 323 15053 SGTC_556 4058-0063 51.5 µM 0.545108379773603 0.281939272808739 no 979 0.292839489841926 330 6615692 SGTC_3311 9131146 2.8755 µM 0.544514621051024 0.2821505226307 no 980 0.293043694908424 327 4900406 YPR165W RHO1 SGTC_289 k017-0060 526 µM 0.543592138804643 0.282478878079824 no 981 0.293361085299047 326 5512909 SGTC_2411 st077133 39.94 µM 0.543364199806936 0.282560040748504 no 982 0.293439534809918 328 1403142 YNL221C POP1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.542697933057843 0.282797343862951 no 983 0.293668898795573 327 23847180 SGTC_2712 st079126 47.7 µM 0.542078231912667 0.283018147681006 no 984 0.293882306913153 323 3152970 SGTC_41 0478-0632 82.643 µM 0.540281355110837 0.283658854803803 no 985 0.29450150727952 356 3750424 SGTC_2492 derrusnin 100 µM 0.538374712538307 0.2843394595858 no 986 0.295159190346517 347 1715307 Part of coumarin class of compounds. SGTC_2557 derrustone 83.84 µM 0.538240877523509 0.284387263309116 no 987 0.295205381192228 341 629853 An antioxidant. SGTC_366 0181-0206 4.31 µM 0.535254302785214 0.285455017728949 no 988 0.296237010467058 331 274874 SGTC_493 zm226600 134 µM 0.532974402827207 0.286271405766621 no 989 0.297025649789636 337 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1702 st027038 51 µM 0.53210046056893 0.286584641240593 no 990 0.297328209211273 308 5521182 SGTC_1797 st048695 56.8 µM 0.530493679596288 0.287160962159057 no 991 0.297884845008929 341 592262 YIL048W NEO1 SGTC_1223 0764-0573 147 µM 0.529821092650855 0.287402368739693 no 992 0.298117989738159 316 1609797 SGTC_3298 9116858 71.43 µM 0.529387157879373 0.287558168615895 no 993 0.298268452469778 362 2506942 SGTC_2181 6316240 54.2555 µM 0.52922929770937 0.287614856611285 no 994 0.298323197550084 317 12779990 SGTC_2993 9054257 71.4286 µM 0.524717367548363 0.289237331043702 no 995 0.299889841066284 328 6470217 YGL055W OLE1 SGTC_757 1066-0008 322 µM 0.523270626960755 0.289758483367482 no 996 0.300392969253753 327 6842497 SGTC_2449 5812982 45.77 µM 0.523246517908813 0.289767171785127 no 997 0.300401356808833 332 776185 SGTC_3181 9108277 49.47 µM 0.523160950566715 0.289798009521799 no 998 0.300431126597782 359 17097298 SGTC_3127 9126946 49.47 µM 0.521585123180886 0.29036619928379 no 999 0.300979611818474 348 27243249 SGTC_98 0074-0023 107.663 µM 0.520944825810936 0.290597217679098 no 1000 0.301202603747149 326 3563821 SGTC_1243 0416-0003 5.65 µM 0.519253419814331 0.291207887839894 no 1001 0.301792015637501 345 2141977 SGTC_305 1682-2595 20.8 µM 0.518913151759587 0.29133081156319 no 1002 0.301910652996597 333 226033 SGTC_1059 3448-6867 171 µM 0.518639172602195 0.291429805649218 no 1003 0.302006193392029 331 3934407 SGTC_1705 st027868 56.3335 µM 0.514519084055475 0.29292036385466 no 1004 0.303444560626583 348 292948 SGTC_328 k915-0120 63.5 µM 0.514041911524784 0.293093222835959 no 1005 0.303611344260927 311 6624543 SGTC_2059 5238311 157 µM 0.513892916141981 0.293147207113922 no 1006 0.303663430226228 319 703021 SGTC_1263 0774-1208 64.8 µM 0.513462441748164 0.293303203278304 no 1007 0.303813938329366 359 906585 SGTC_1932 st074806 40.9 µM 0.512789250988474 0.293547232578119 no 1008 0.304049374802059 371 17251235 SGTC_1824 st053723 68.6 µM 0.511042981885632 0.294180686885519 no 1009 0.304660480030567 345 675225 SGTC_2675 theaflavin digallate 100 µM 0.509920990587843 0.294588019108723 no 1010 0.305053407810516 321 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_156 3474-0145 5.642 µM 0.507422547962981 0.295495997333741 no 1011 0.305929184078314 315 2265471 SGTC_2848 9016370 25.97 µM 0.504936695300723 0.296400675338911 no 1012 0.306801649807062 329 7894410 SGTC_627 1391-0720 175 µM 0.50412008592701 0.296698141334967 no 1013 0.307088496486603 384 997839 SGTC_2190 6049624 200 µM 0.503752592351777 0.296832052672139 no 1014 0.307217622836527 341 2265554 SGTC_1553 gossypol 38.6 µM 0.5035595735328 0.296902398063625 no 1015 0.307285453505167 348 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_971 1315-0384 26.7 µM 0.503450184355311 0.29694226815596 no 1016 0.307323897974454 352 6769120 SGTC_218 alverine citrate 93.75 µM 0.502737067728611 0.297202244428265 no 1017 0.307574572360833 354 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1723 st034307 2.5525 µM 0.50090569929976 0.29787037064983 no 1018 0.308218745637773 330 867466 SGTC_2057 5236571 38.335 µM 0.500612185627142 0.297977514980269 no 1019 0.30832204238921 343 54684039 YBR257W POP4 SGTC_577 r071-0003 38.6 µM 0.500572871621051 0.297991867512323 no 1020 0.308335879385166 352 4568517 YMR134W ERG29 SGTC_2817 7995342 71.43 µM 0.499724059365919 0.298301823836218 no 1021 0.308634694556416 327 18879975 SGTC_1658 st012944 20 µM 0.499336006260417 0.298443576029844 no 1022 0.308771346691312 344 24207260 SGTC_1422 4031-0024 15.5 µM 0.498993945410857 0.298568553091411 no 1023 0.308891824704187 356 782427 SGTC_220 paclitaxel 373.376 µM 0.498222595191151 0.298850464786923 no 1024 0.30916357914186 342 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3211 9128781 49.47 µM 0.498194026178089 0.298860908460969 no 1025 0.309173646299206 355 17194361 SGTC_747 3448-8087 38.7 µM 0.497729623775027 0.299030698420887 no 1026 0.309337312647656 354 5168703 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.496567987490477 0.29945559543801 no 1027 0.309746866268634 347 4620898 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.496287771119025 0.299558132425304 no 1028 0.309845696466511 375 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_324 1315-0088 19.6 µM 0.495731516770959 0.299761724567325 no 1029 0.310041923892616 364 6787421 SGTC_283 0987-0079 11.7 µM 0.495100095714414 0.299992904041978 no 1030 0.310264733130144 342 411556 SGTC_1612 st002233 45.4 µM 0.494770774137302 0.30011350913494 no 1031 0.310380968319437 333 1035021 SGTC_686 1319-0111 510 µM 0.493694442312146 0.300507839337024 no 1032 0.310760995423125 370 4562600 SGTC_2373 9071805 200 µM 0.490727730974713 0.301595947620051 no 1033 0.311809515120609 351 10149009 SGTC_2376 9072922 81.32 µM 0.489993824720217 0.30186539748606 no 1034 0.312069134311075 331 17087968 SGTC_1522 st012842 45.6 µM 0.489267536095403 0.302132157026229 no 1035 0.31232615069644 344 3491067 YOR116C RPO31 SGTC_731 3966-0296 387 µM 0.488261475048764 0.302501849281724 no 1036 0.312682322815709 346 660956 SGTC_636 0kpi-0074 126 µM 0.488174909274458 0.302533668650324 no 1037 0.312712977561438 334 616434 SGTC_1466 k213-0079 57.5 µM 0.487171946435519 0.302902441520241 no 1038 0.313068242027199 351 3657981 SGTC_2846 9008642 19.48 µM 0.486995026394755 0.302967512969898 no 1039 0.313130927779629 364 2992898 SGTC_3089 9117425 49.47 µM 0.485424079371508 0.303545583764039 no 1040 0.313687777521134 363 9401657 SGTC_3173 9105693 49.47 µM 0.485190643241937 0.303631524674098 no 1041 0.313770559331216 346 17096658 SGTC_418 lividomycin a 100 µM 0.484776545428593 0.303784003984728 no 1042 0.313917430988831 336 72394 An antibiotic. SGTC_1383 3049-0032 20.7 µM 0.484089069449996 0.304037222155425 no 1043 0.314161329150502 373 712864 SGTC_3147 9097027 49.47 µM 0.481479662387578 0.304999200660135 no 1044 0.315087815370638 376 25236841 SGTC_2145 5634607 200 µM 0.479838456039708 0.305604935965582 no 1045 0.315671132875451 345 308662 SGTC_34 0469-0683 81.75 µM 0.479797221075974 0.305620161800572 no 1046 0.315685794528048 343 3690923 SGTC_1130 3454-2858 15.9 µM 0.477607291050711 0.306429266553963 no 1047 0.316464870260092 383 715628 YIL048W NEO1 SGTC_3130 9127414 49.47 µM 0.475237482101866 0.307305894783779 no 1048 0.317308856979582 331 1494646 SGTC_2228 7354201 200 µM 0.473998058165722 0.307764815763201 no 1049 0.317750645976861 376 753451 SGTC_1144 3486-0183 12.5 µM 0.473941159813622 0.307785890721457 no 1050 0.317770933463027 375 6744069 SGTC_2558 carylophyllene oxide 100 µM 0.473222179887711 0.30805225308646 no 1051 0.318027337658767 352 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1748 st037455 53.6035 µM 0.472060077238688 0.308482994096805 no 1052 0.318441953694407 363 580690 SGTC_1378 2093-0007 380 nM 0.469937424902022 0.30927044972741 no 1053 0.319199862520981 386 3618014 SGTC_1186 1319-0216 26 µM 0.469923800698511 0.30927550683222 no 1054 0.319204729590222 341 4565136 SGTC_2951 9072950 58.06 µM 0.466903999064037 0.310397303078869 no 1055 0.320284282005218 352 16488155 SGTC_179 1273-0063 6.77 µM 0.466403620793158 0.310583354488777 no 1056 0.32046331013151 378 3108139 SGTC_546 peri-Naphthalide 147 µM 0.465844234519229 0.310791403714062 no 1057 0.3206634999366 331 223824 A penicillin ester. SGTC_20 0481-0013 4.944 µM 0.465410015776139 0.310952941839864 no 1058 0.320818931507193 349 182045 SGTC_2690 usnic acid 100 µM 0.464551868562412 0.31127229703699 no 1059 0.321126203543508 367 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_435 c-PAF 6.7 µM 0.46407332282206 0.311450447176373 no 1060 0.32129760699851 348 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1674 st016616 23.6 µM 0.464056915890134 0.311456555833773 no 1061 0.321303484237977 333 625830 SGTC_129 0088-0017 176.636 µM 0.463871940060973 0.311525429946951 no 1062 0.321369748792643 354 182446 SGTC_2505 galangin 7.89 µM 0.46221818512719 0.312141483810224 no 1063 0.321962431807468 375 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2483 5729050 27.16 µM 0.461440702525481 0.312431292036764 no 1064 0.322241227574502 373 2865180 SGTC_2771 fluoxetine 41.05 µM 0.458837822137451 0.313402364850419 no 1065 0.32317531601731 378 3386 A selective serotonin reuptake inhibitor. SGTC_480 am 92016 50 µM 0.455883201865988 0.314506232768943 no 1066 0.324236984805913 381 2129 K+ channel blocker. SGTC_3077 9117319 49.47 µM 0.454459343751551 0.31503879018482 no 1067 0.324749123975804 361 17154678 SGTC_2933 9026794 32.47 µM 0.453308665794787 0.31546945277252 no 1068 0.325163246819358 385 17586027 SGTC_1475 4092-1048 11.7 µM 0.450802704221754 0.316408222632492 no 1069 0.326065876065329 360 2881759 SGTC_1810 st050138 53 µM 0.448418941836971 0.317302314240605 no 1070 0.326925436971127 396 3444541 SGTC_2310 7668677 200 µM 0.448396258986468 0.317310827163071 no 1071 0.326933620602074 393 2197143 SGTC_1861 st057647 17.4 µM 0.447810488370425 0.317530701597082 no 1072 0.32714498664084 398 688668 SGTC_1450 4112-4260 37.6 µM 0.447480979858686 0.317654413975573 no 1073 0.327263908935936 363 1633175 SGTC_785 1270-0111 65.3 µM 0.447338971095715 0.317707736759291 no 1074 0.327315166458542 338 6741994 SGTC_1317 1273-0028 910 nM 0.445824545694188 0.318276622427053 no 1075 0.327861994906584 353 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2643 anethole 100 µM 0.444690530427903 0.31870288999716 no 1076 0.328271706807809 394 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3307 9126885 69.2785 µM 0.443978430514075 0.318970685564538 no 1077 0.328529089258717 352 24824909 SGTC_73 0327-0325 16.231 µM 0.443880755007212 0.3190074252397 no 1078 0.328564399588694 326 53298 SGTC_826 1683-5028 118 µM 0.443206237539173 0.319261186833228 no 1079 0.328808283809575 364 722377 SGTC_632 0781-2353 4.65 µM 0.441550979587032 0.319884273565483 no 1080 0.329407081680102 370 6811515 YHR007C ERG11 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.441522016038779 0.319895180810487 no 1081 0.329417563290279 358 4330530 SGTC_738 1315-0003 72.4 µM 0.441221479683222 0.320008367557603 no 1082 0.329526332215958 378 6251474 SGTC_2380 9035439 200 µM 0.44024288912099 0.320377036313574 no 1083 0.329880599738144 354 6462575 SGTC_1278 0874-0585 172 µM 0.440216171177633 0.320387104371299 no 1084 0.329890274260054 356 766306 SGTC_909 3448-9333 149 µM 0.439883102657807 0.320512624867019 no 1085 0.33001088735447 360 3344074 SGTC_1657 st012939 43.4 µM 0.439364759974042 0.32070800878343 no 1086 0.330198628369314 354 24207257 SGTC_1863 st057641 20.1 µM 0.439296691339148 0.320733670243202 no 1087 0.330223285650907 375 3921635 SGTC_1796 st049173 110.4 µM 0.438749247096581 0.320940084521751 no 1088 0.330421619454793 380 94134 SGTC_941 3237-0776 460 µM 0.438099566272057 0.321185119008368 no 1089 0.330657054409738 375 760008 SGTC_2867 9039098 71.43 µM 0.437901393763657 0.32125987751999 no 1090 0.330728882610064 369 6463460 SGTC_1827 berberine 7.24 µM 0.437810348673754 0.321294225758833 no 1091 0.330761884256815 361 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1132 3456-3614 2.5 µM 0.437336932086405 0.321472854488256 no 1092 0.330933507538001 357 3125502 SGTC_1516 st013856 110 µM 0.437030008772338 0.321588684329486 no 1093 0.331044792562146 365 5281404 A mutagen and neurotoxin. SGTC_385 1494-0393 12.4 µM 0.434985754342661 0.322360607937086 no 1094 0.331786383881819 365 3090647 SGTC_1184 1269-1718 139 µM 0.434135087253481 0.322682051369265 no 1095 0.332095173721542 343 5403821 SGTC_804 1595-0054 20.9 µM 0.433385842059687 0.322965280093672 no 1096 0.332367242166072 372 761523 Stimulates phospholipase C. SGTC_2182 6325192 200 µM 0.43286042148391 0.323163960188456 no 1097 0.332558087374504 354 736248 SGTC_1237 0330-0133 46.1 µM 0.432764421213465 0.32320026673774 no 1098 0.332592961640006 385 X1237 YHR072W ERG7 SGTC_3156 9099931 49.47 µM 0.432761523535286 0.323201362643085 no 1099 0.332594014309549 357 18111053 SGTC_1505 k297-0037 20.6 µM 0.43238989995339 0.323341923839117 no 1100 0.332729028792564 347 4089396 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.429846084502369 0.324304761182709 no 1101 0.333653803607593 344 16623 A steroid. SGTC_1669 st015249 58.4 µM 0.428476744713715 0.324823545362925 no 1102 0.334152030529509 369 722793 SGTC_2726 cimetidine 79.27 µM 0.428108080279886 0.324963274645562 no 1103 0.334286217093971 381 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_206 4546-0025 72.014 µM 0.427893876724591 0.325044472278817 no 1104 0.334364192681892 378 6620745 YIL048W NEO1 SGTC_1604 st002052 72.4 µM 0.427769184056923 0.325091743059434 no 1105 0.334409587302456 332 6254834 YHR062C RPP1 SGTC_810 3825-7150 143 µM 0.426800367340854 0.325459115715035 no 1106 0.334762369457373 345 22330411 YGL099W LSG1 SGTC_1408 3909-7976 48.8 µM 0.426747993084859 0.325478980726474 no 1107 0.334781445028904 360 24152374 SGTC_2728 chlorpromazine 9.18 µM 0.426697284841449 0.325498214309004 no 1108 0.334799914217285 403 2726 A thorazine and dopamine antagonist. SGTC_3070 9117005 49.47 µM 0.42504839896419 0.326123887936838 no 1109 0.335400696522661 356 8779016 SGTC_887 0885-0007 9.62 µM 0.424606257543842 0.326291742886635 no 1110 0.335561865299162 376 5719458 SGTC_753 1322-0200 289 µM 0.423537607641976 0.326697591319748 no 1111 0.335951532982762 345 5403907 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.422989304915074 0.326905903638028 no 1112 0.33615153211657 382 688667 SGTC_1815 st051655 58.2 µM 0.422557665405145 0.327069930982974 no 1113 0.3363090097633 358 5984156 SGTC_2838 9002687 71.43 µM 0.421739750566502 0.327380838446321 no 1114 0.336607493336453 380 6457060 SGTC_2390 9097792 176.6 µM 0.420425930892058 0.32788050093156 no 1115 0.337087164111768 361 4497149 SGTC_1320 1313-0481 95.3 µM 0.419991973078258 0.328045608429827 no 1116 0.33724565878808 357 6813365 YLR208W SEC13 SGTC_316 k060-0003 58.6 µM 0.416002387283246 0.32956509339223 no 1117 0.338704128163643 379 6152314 SGTC_141 0443-0274 32.331 µM 0.415747843202138 0.329662135668253 no 1118 0.338797264037536 337 1627241 SGTC_2058 5236698 133 µM 0.414966913470114 0.329959928531943 no 1119 0.339083062173668 352 766665 SGTC_939 1165-0479 45.3 µM 0.414793825242014 0.330025947071305 no 1120 0.339146420102548 400 1377347 SGTC_1664 st014217 9.02 µM 0.414678854278949 0.330069801708911 no 1121 0.339188507062463 386 3982782 SGTC_2818 7996756 12.99 µM 0.413043029994525 0.33069402486243 no 1122 0.339787543867563 388 2241621 SGTC_321 4534-3890 65.3 µM 0.41304022805828 0.330695094473326 no 1123 0.339788570280837 386 699746 SGTC_2958 9077254 16.72 µM 0.41248401513935 0.330907450511333 no 1124 0.339992347297459 343 16457351 SGTC_650 1328-0195 38 µM 0.412252169666632 0.330995982662277 no 1125 0.340077301203455 389 2780821 SGTC_3287 9117173 37.0625 µM 0.410975543922374 0.331483642164516 no 1126 0.340545233755387 348 2789709 SGTC_2950 9072895 21.46 µM 0.409884664250036 0.331900574858178 no 1127 0.340945277810561 328 17332245 SGTC_2416 tofa 880 nM 0.409689924279644 0.331975026125316 no 1128 0.341016711088312 341 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1024 4507-0395 26 µM 0.409529503914494 0.332036361607727 no 1129 0.341075559748043 349 4201836 SGTC_838 0109-0203 71.4 µM 0.408644298367294 0.332374893984184 no 1130 0.34140035833833 351 759422 SGTC_1893 st059353 36.1 µM 0.406294370864749 0.333274248299132 no 1131 0.342263160484762 399 3112488 SGTC_272 doxorubicin 8.13 µM 0.406179341080239 0.333318296684773 no 1132 0.342305416147128 375 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1560 lithocholic acid 53.1 µM 0.405976242496934 0.333396074891045 no 1133 0.342380028297837 380 9903 A bile acid which acts as a detergent. SGTC_848 0368-0089 85.6 µM 0.404550093677541 0.33394243143985 no 1134 0.342904124487335 404 762535 SGTC_3276 9139060 49.47 µM 0.404003659007137 0.334151863539131 no 1135 0.34310501425111 405 4870619 SGTC_2524 avocatin b 10.57 µM 0.403583030932502 0.334313112910575 no 1136 0.343259683032765 363 6710748 SGTC_1697 st025554 27.742 µM 0.402581454773765 0.334697193988491 no 1137 0.343628077387829 361 1269519 SGTC_1427 4048-4900 550 nM 0.400953917997815 0.335321685232445 no 1138 0.344227025941708 381 24132586 SGTC_400 oxethazaine 37.5 µM 0.400723344438368 0.335410193932748 no 1139 0.344311910789168 382 4621 A local anesthetic. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.400494216814993 0.335498156641443 no 1140 0.344396271090116 383 688669 SGTC_1547 harmine 94.2 µM 0.400326849256127 0.335562415195145 no 1141 0.344457897438556 372 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2235 salicylic acid 500 µM 0.400302891953239 0.335571613677287 no 1142 0.344466719086273 354 338 A COX inhibitor and kinase inhibitor. SGTC_2496 diffractaic acid 79.83 µM 0.398946685726999 0.336092493884984 no 1143 0.344966244241509 370 94870 An apoptosis inducer which activates caspases. SGTC_452 diindolylmethane 8 µM 0.396950694089935 0.336859670020289 no 1144 0.34570191009645 396 3071 Inhibits expression of several cancer promoting factors. SGTC_2733 amorolfine 100 µM 0.396294237937635 0.337112133043941 no 1145 0.345943988743896 398 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2420 aureobasidin a 50 nM 0.396238947498351 0.337133400255656 no 1146 0.345964380849909 344 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2096 5468907 200 µM 0.39365396920588 0.338128280238348 no 1147 0.346918265038747 370 759785 SGTC_2038 4100038 30.985 µM 0.393570486007902 0.338160429294076 no 1148 0.346949087434589 376 3596803 SGTC_1688 st021091 57.6 µM 0.393048226413981 0.338361576214201 no 1149 0.347141931151315 395 3656366 SGTC_2789 5281112 71.43 µM 0.392896384745236 0.338420066295684 no 1150 0.347198005932289 358 765948 SGTC_1480 1070-0044 41.2 µM 0.391664606905456 0.338894696545877 no 1151 0.347653022223232 372 3124987 SGTC_1113 artemisinin 1.17947 µM 0.390510292253795 0.339339710859068 no 1152 0.348079623071645 381 2240 An anti-malaria and mitochondrial poison. SGTC_1834 st055981 52.8 µM 0.389382978955611 0.339774531923931 no 1153 0.3484964306619 383 471719 YDL150W RPC53 SGTC_432 NS 1619 61.3 µM 0.389065416025548 0.339897059074957 no 1154 0.34861387796267 349 4552 A K+/calcium channel activator. SGTC_2241 6772625 37.8075 µM 0.388596662905952 0.340077951725157 no 1155 0.34878726787775 365 2285411 SGTC_1509 1326-1131 80 µM 0.38737238146391 0.34055057765182 no 1156 0.349240273615704 368 768313 SGTC_3032 9089427 49.47 µM 0.386977633807267 0.340703020869768 no 1157 0.349386383056415 382 17173707 SGTC_199 4063-0024 41.6 µM 0.386154451950212 0.341021000025139 no 1158 0.349691142249767 392 306215 SGTC_2423 st077119 87.2 µM 0.385958973626941 0.34109652610757 no 1159 0.349763526668659 347 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1950 st077106 7.18 µM 0.385164874030321 0.341403404248085 no 1160 0.350057632989008 353 13831864 SGTC_1798 st045719 60.953 µM 0.384912291333938 0.341501036304246 no 1161 0.350151199526579 412 3980186 SGTC_475 α-linolenic acid 10 µM 0.382170166697115 0.342561644913332 no 1162 0.351167574446974 371 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_42 0133-0086 60.653 µM 0.381499756199629 0.342821137984988 no 1163 0.351416226039416 421 162923 Model of phenazepam hydroxylation. SGTC_654 1124-0271 80.9 µM 0.37907004568303 0.343762216940045 no 1164 0.352317924671726 391 5403748 SGTC_1687 st020778 55.3625 µM 0.376600910234093 0.344719558826928 no 1165 0.353235105613907 371 4259299 SGTC_3080 9117754 49.47 µM 0.376418184350189 0.344790445573869 no 1166 0.353303014634283 393 9550191 SGTC_2205 7238770 200 µM 0.373979997402072 0.345736837309478 no 1167 0.354209598972539 386 279867 SGTC_1117 retinoic acid 1.10837 µM 0.371766463818087 0.34659686479452 no 1168 0.355033367430147 384 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_87 0100-0052 35.5 µM 0.370804988894659 0.346970674832888 no 1169 0.355391392629186 381 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_908 3448-7491 47.7 µM 0.370549102904057 0.34707018538426 no 1170 0.355486698625048 347 1203031 SGTC_1026 k007-1105 30.6 µM 0.370081042825313 0.347252234813147 no 1171 0.355661053283788 363 7066794 SGTC_1327 1436-0082 2.18 µM 0.369985754516555 0.347289301003859 no 1172 0.355696552344355 386 15992205 SGTC_1434 4073-0095 163 µM 0.369061570850826 0.347648874860654 no 1173 0.356040916053118 395 24133745 SGTC_1490 4089-0339 670 nM 0.368647527719926 0.347810011881825 no 1174 0.35619523241153 396 742542 SGTC_1995 st072814 61.1 µM 0.36706261757671 0.348427079947859 no 1175 0.356786155394107 366 5769371 SGTC_606 k015-0008 38.6 µM 0.366849047858304 0.348510261789007 no 1176 0.35686580973248 387 1970475 SGTC_2023 5144124 124 µM 0.366668670650659 0.348580521376056 no 1177 0.356933089239707 391 2830192 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.366454446402982 0.348663971633046 no 1178 0.357012999249965 378 1609 A potent and irreversible inhibitor of serine proteases. SGTC_294 k038-0071 157 µM 0.366148185852377 0.348783287006245 no 1179 0.357127251571407 388 24152826 SGTC_3332 9141069 11.198 µM 0.365291341407651 0.349117182572432 no 1180 0.35744697053088 378 17332883 SGTC_2293 7624732 200 µM 0.365010705310153 0.349226566398158 no 1181 0.357551707550392 376 894453 SGTC_1930 st074634 34.3 µM 0.364565345121183 0.349400180614306 no 1182 0.357717943751651 372 684253 YOR116C RPO31 SGTC_2870 9038528 12.99 µM 0.362532658480127 0.350192980013415 no 1183 0.358477011508452 393 6463316 SGTC_1057 3448-5381 134 µM 0.361364123259793 0.35064903438314 no 1184 0.358913632007054 384 5497911 SGTC_2714 st079313 56.9 µM 0.360698727683312 0.350908820341172 no 1185 0.35916233796859 376 2939799 SGTC_1826 st055655 41.6 µM 0.360587403022224 0.35095229089668 no 1186 0.359203953796059 383 676168 SGTC_133 0724-0033 378.92 µM 0.35875400548357 0.351668484480579 no 1187 0.35988956173045 404 280309 SGTC_2306 7482397 179.52 µM 0.358742748966306 0.351672883326421 no 1188 0.359893772555241 420 891448 SGTC_984 1492-0255 2.91 µM 0.357386242066774 0.35220312723222 no 1189 0.360401337425968 399 1585198 SGTC_3162 9099653 49.47 µM 0.357170855527112 0.352287345976458 no 1190 0.360481951379656 369 25237511 SGTC_2916 7875993 68.79 µM 0.356872545085467 0.35240400093356 no 1191 0.360593611979403 410 1299250 SGTC_215 1287-0124 461.5 µM 0.35675020740119 0.352451845370709 no 1192 0.360639407643314 402 5560863 SGTC_839 0122-0028 230 µM 0.355458794831285 0.352957039764698 no 1193 0.361122954446958 392 759448 SGTC_1556 plumbagin 1.48 µM 0.351436237588593 0.35453230330002 no 1194 0.362630550152496 400 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1284 0929-0043 16 µM 0.351279015950205 0.354593923233196 no 1195 0.362689517973845 398 1239883 SGTC_2883 9059145 45.46 µM 0.351131983694444 0.354651553081536 no 1196 0.362744667094674 418 16476510 SGTC_701 4424-0219 185 µM 0.350258102014061 0.354994142918536 no 1197 0.363072502910548 390 2911779 SGTC_1864 st057645 30.4 µM 0.350120746766774 0.355048001282459 no 1198 0.363124040723236 409 688666 SGTC_2315 7733312 200 µM 0.348343034451781 0.3557453210033 no 1199 0.36379128919295 360 726316 SGTC_3134 9127454 49.47 µM 0.348059630795851 0.355856532707603 no 1200 0.363897700475176 395 24262820 SGTC_181 1447-1644 8.07 µM 0.346737159688408 0.356375651602622 no 1201 0.364394395346609 398 534600 SGTC_2955 9076254 12.21 µM 0.346713282431054 0.35638502676033 no 1202 0.364403365284107 385 16459619 SGTC_1620 st003704 16.5 µM 0.346109647143352 0.356622066720983 no 1203 0.364630156805883 392 2834414 SGTC_1298 1079-1278 263 µM 0.34603949759816 0.356649617156237 no 1204 0.364656515732403 402 2840950 SGTC_428 3448-4153 16.5 µM 0.34576707805347 0.35675661392162 no 1205 0.364758884354772 370 3834874 SGTC_1185 1319-0113 81.3 µM 0.344368050952861 0.357306279716144 no 1206 0.36528475640299 404 4672763 SGTC_51 1013-0126 23.419 µM 0.344087160070328 0.357416675086997 no 1207 0.365390369397443 417 1627850 SGTC_1685 st024049 53.0905 µM 0.344074085115513 0.357421814079535 no 1208 0.36539528573711 417 1941139 SGTC_367 0335-0881 7.1 µM 0.344046709328647 0.357432573968294 no 1209 0.365405579432605 412 23828853 SGTC_381 3461-2219 42.7 µM 0.340727409324902 0.35873804260194 no 1210 0.366654401212585 412 2883159 SGTC_611 3453-1652 23.7 µM 0.340540820813343 0.358811476369009 no 1211 0.366724643561121 395 1560575 SGTC_1923 st058458 19.1 µM 0.339946210296965 0.359045526063845 no 1212 0.366948517971286 420 3534982 SGTC_1550 gossypolone 36.6 µM 0.338459213137665 0.359631067122332 no 1213 0.367508579237416 375 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1474 0330-0125 5.35 µM 0.338013129590286 0.359806787645226 no 1214 0.367676646767947 376 X1474 SGTC_635 k038-0028 24.7 µM 0.336897321540879 0.360246454694332 no 1215 0.368097152258111 413 4035102 SGTC_1633 st005664 67.9 µM 0.336665979492136 0.360337634641259 no 1216 0.368184356054851 387 2063822 SGTC_2567 aureobasidin a 60 nM 0.335084884447454 0.360961011613084 no 1217 0.368780527433441 400 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_559 1550-0661 158 µM 0.333365323635838 0.361639400821973 no 1218 0.369429267642519 411 5830875 SGTC_2139 5578692 56.4705 µM 0.333174214228134 0.361714822885289 no 1219 0.369501390655533 396 650991 YMR113W FOL3 SGTC_338 4055-0136 114 µM 0.330419176411866 0.362802704805557 no 1220 0.370541626884673 381 2900563 SGTC_1751 st044839 27.194 µM 0.329186548344131 0.363289792105381 no 1221 0.371007344863741 368 5291326 SGTC_3117 9124945 49.47 µM 0.32789266039434 0.363801324875038 no 1222 0.371496411694296 379 17592065 SGTC_1145 3546-0597 10.2 µM 0.327684533229439 0.363883629708214 no 1223 0.371575099488106 389 875334 SGTC_2803 7707263 71.43 µM 0.327212576083541 0.364070290569152 no 1224 0.371753554827316 407 2199229 SGTC_2912 7964298 10.93 µM 0.326807163672023 0.364230658487291 no 1225 0.371906870433489 400 2975850 SGTC_246 cycloheximide 667 µM 0.326671446376956 0.364284349132489 no 1226 0.371958199448593 399 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1091 telmisartan 47.6 µM 0.325518017352358 0.364740760566688 no 1227 0.372394524316351 406 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2806 7952793 58.44 µM 0.325207443608608 0.364863687277009 no 1228 0.372512037717943 383 2972490 SGTC_1939 st074455 53.6 µM 0.324445612858102 0.36516528268015 no 1229 0.372800345825807 431 1644229 SGTC_1467 k284-1082 293 µM 0.322821862648097 0.365808375018105 no 1230 0.373415077375322 403 3334705 SGTC_2175 5807670 165.306 µM 0.321539203191113 0.366316643917116 no 1231 0.3739009041646 390 241186 SGTC_733 4069-0007 56.1 µM 0.321022331639973 0.366521526718013 no 1232 0.374096733821577 396 5717425 YNL287W SEC21 SGTC_2936 9038235 15.59 µM 0.32059625940506 0.366690446172196 no 1233 0.374258186333464 393 4749415 SGTC_1899 st063254 59.6 µM 0.31990987206601 0.366962623747381 no 1234 0.374518327007501 386 3093813 SGTC_2928 9011484 9.79 µM 0.318518738897268 0.367514463738175 no 1235 0.375045741330488 417 2994751 SGTC_259 usnic acid 108.925 µM 0.317473026642609 0.367929461109282 no 1236 0.375442351655967 436 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1240 0356-0016 42.1 µM 0.316778660318986 0.368205109901399 no 1237 0.375705778767596 407 4305613 SGTC_2276 7947513 42.08 µM 0.315858766552163 0.368570392819196 no 1238 0.376054855186426 404 2105100 SGTC_155 k072-0202 43.6 µM 0.31410782952228 0.36926600480979 no 1239 0.376719571585392 428 5857737 SGTC_2033 5192550 145 µM 0.312929716105447 0.369734286706871 no 1240 0.377167030195884 388 182073 SGTC_1034 k072-0165 12.7 µM 0.310414547487729 0.370734673350774 no 1241 0.378122866429902 422 5835461 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.310371852928424 0.370751662311034 no 1242 0.378139098046673 429 91467 include heat shock SGTC_2782 7736369 71.43 µM 0.310136231799089 0.370845424878421 no 1243 0.378228680351539 401 2950836 YOL077C BRX1 SGTC_1236 0330-0013 258 µM 0.310095804334532 0.370861513268075 no 1244 0.378244051386077 404 4617066 SGTC_1100 amiodarone 5.07 µM 0.30980748558429 0.370976258257527 no 1245 0.378353679416335 394 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_584 0986-0246 15.4 µM 0.309611513049913 0.371054257884444 no 1246 0.378428200046129 441 53315 YDR232W HEM1 SGTC_3146 9095609 49.47 µM 0.309048247578348 0.371278474380944 no 1247 0.378642412867821 386 17173999 SGTC_1915 st067105 30.6 µM 0.306795716996891 0.37217556493452 no 1248 0.379499434249644 425 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1039 k821-0043 94 µM 0.305272101653745 0.372782752348782 no 1249 0.380079461048373 414 15992768 SGTC_674 0498-0004 451 µM 0.304811894721015 0.372966215128078 no 1250 0.380254710849401 400 4231473 SGTC_2242 6630449 61.2675 µM 0.30444581917597 0.373112172744946 no 1251 0.380394132362222 407 691249 YDR170C SEC7 SGTC_771 0250-0039 27.3 µM 0.301168757152856 0.374419575864524 no 1252 0.381642906312018 445 3005115 SGTC_2289 7946404 165.07 µM 0.300514016257315 0.374680962290617 no 1253 0.38189255339654 403 1246120 YPR165W RHO1 SGTC_3295 9122362 53.5725 µM 0.300282396648099 0.374773443538072 no 1254 0.381980879733868 407 4730473 SGTC_2237 6667747 47.222 µM 0.300094247843722 0.374848573032486 no 1255 0.382052633340027 444 729940 YDL015C TSC13 SGTC_1730 st033808 45.1 µM 0.298524251139322 0.37547567164029 no 1256 0.38265153484916 409 1045166 SGTC_2362 9071156 126 µM 0.296114366645151 0.376438883779407 no 1257 0.383571371368691 393 653133 SGTC_139 0099-0334 718.624 µM 0.295061705788264 0.376859866127489 no 1258 0.383973371199646 401 97690 SGTC_691 1548-0686 185 µM 0.294537078825712 0.377069730761627 no 1259 0.384173767233523 431 46495133 SGTC_2297 7971671 152.32 µM 0.293998707133244 0.377285131409735 no 1260 0.384379445649011 416 909016 SGTC_2620 irigenin 100 µM 0.293630509423986 0.37743246802879 no 1261 0.38452012989611 457 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_683 panaxydol 45 µM 0.293207545487151 0.377601741713937 no 1262 0.384681758480952 405 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2269 7935389 174.42 µM 0.292575121724243 0.377854886815046 no 1263 0.384923466016692 425 97605 SGTC_1080 nisoldipine 24.4 µM 0.291876527634016 0.378134579401155 no 1264 0.38519051533518 446 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_889 0919-1524 82.7 µM 0.291043073856133 0.378468348636171 no 1265 0.385509188264793 400 3905452 SGTC_50 0929-0078 56.389 µM 0.289163231837323 0.379221492554632 no 1266 0.386228233616662 428 1377751 SGTC_2539 epi(13)torulosol 80 µM 0.289012166050729 0.37928203582124 no 1267 0.386286033747068 400 6708597 SGTC_1628 st004252 77.7 µM 0.286568274997927 0.380261894675814 no 1268 0.387221454447349 392 692968 SGTC_1389 3405-0187 19 µM 0.286560898905679 0.380264853228841 no 1269 0.387224278705781 426 799890 SGTC_2875 9039966 71.43 µM 0.285664419031021 0.380624483717167 no 1270 0.387567579513491 429 6463691 SGTC_2634 4'-methoxyflavone 100 µM 0.285491307344298 0.380693940830807 no 1271 0.387633881581067 408 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2027 5150920 200 µM 0.285291381317127 0.380774161371622 no 1272 0.387710457663601 428 786715 SGTC_204 PMA1.184 62.41 µM 0.284439585644511 0.38111600273639 no 1273 0.388036763126161 405 2252213 YGL008C PMA1 SGTC_2923 7992654 58.14 µM 0.283980796941971 0.381300161599104 no 1274 0.388212548450653 422 2985126 SGTC_170 4197-0004 226 µM 0.282940812550457 0.381717713247551 no 1275 0.388611104203535 410 218692 SGTC_1868 st057644 42.7 µM 0.282424354380918 0.3819251213563 no 1276 0.388809071338531 393 688665 SGTC_2564 betulinic acid 100 µM 0.282115484586509 0.382049178774673 no 1277 0.388927480147551 405 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1759 st043059 70 µM 0.281532189616208 0.382283491969486 no 1278 0.38915112115637 414 669426 SGTC_2428 5615643 7.78 µM 0.280913057968744 0.382532248146142 no 1279 0.389388542479543 447 2253075 SGTC_697 0508-1955 564 µM 0.277633622322033 0.383850673704984 no 1280 0.39064680976344 421 6243113 SGTC_883 0850-0245 24.6 µM 0.276934874358973 0.384131764488542 no 1281 0.390915056785523 430 6823229 YPR165W RHO1 SGTC_2081 5214970 32.255 µM 0.276694677219457 0.384228404547946 no 1282 0.391007279665466 413 2063512 SGTC_1794 st048918 76.9 µM 0.276256955539974 0.384404534430979 no 1283 0.391175357184253 429 672303 SGTC_2257 7960413 200 µM 0.275743761293014 0.38461106326194 no 1284 0.391372440740122 426 2974689 YIL048W NEO1 SGTC_894 0960-0238 55.9 µM 0.273517963342476 0.38550718716519 no 1285 0.392227542928559 439 6741907 YDL195W SEC31 SGTC_307 1501-1223 22.3 µM 0.273311457776988 0.385590359017245 no 1286 0.392306904243069 430 2830329 SGTC_840 0245-0196 390 µM 0.273109191984698 0.38567182836523 no 1287 0.392384640529898 404 3827528 SGTC_196 k015-0023 18.111 µM 0.272826720661167 0.385785611627269 no 1288 0.392493209185885 414 5211998 SGTC_807 1315-0151 48 µM 0.272799858795883 0.385796432461082 no 1289 0.392503534055954 436 4011080 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.272601194531514 0.385876463652747 no 1290 0.392579896802215 465 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_176 1486-1328 72.834 µM 0.271932055166488 0.386146059780533 no 1291 0.392837131592543 398 22310231 SGTC_1526 st051518 75 µM 0.270696541553547 0.386643992394083 no 1292 0.393312218488974 415 673993 SGTC_811 0416-0114 265 µM 0.267800766039622 0.387811768471492 no 1293 0.394426340521042 438 6612453 SGTC_3078 9116413 49.47 µM 0.265871364896196 0.388590400233594 no 1294 0.395169139552212 430 17177322 SGTC_752 1896-0090 130 µM 0.26553799799546 0.388724979697866 no 1295 0.395297520970201 429 772567 SGTC_854 0422-0053 192 µM 0.265503837172634 0.388738771099514 no 1296 0.395310677132226 425 3596728 SGTC_3024 9090631 49.47 µM 0.26509037410437 0.38890570545501 no 1297 0.395469921253479 429 25236383 SGTC_2451 5856223 45.7 µM 0.264893736960903 0.388985104255313 no 1298 0.395545661614538 420 2179896 SGTC_2149 5554786 194.827 µM 0.264509847797306 0.389140125658648 no 1299 0.395693538757824 406 745063 YPR165W RHO1 SGTC_209 4077-0173 175.592 µM 0.26428209389732 0.389232105154903 no 1300 0.395781278460765 428 15993494 SGTC_2268 7933382 153.85 µM 0.264136770518955 0.389290797936926 no 1301 0.395837265465684 379 935025 YOR257W CDC31 SGTC_2092 5303694 80.6725 µM 0.263038567860261 0.38973441839988 no 1302 0.396260426315407 438 1963699 SGTC_1062 mesoridazine 14.2 µM 0.261794200970475 0.390237255734638 no 1303 0.396740055073785 434 4078 A neuroleptic. SGTC_3143 9086658 49.47 µM 0.26150822530329 0.390352841887572 no 1304 0.396850303640329 416 25236626 SGTC_1319 1306-0155 43.7 µM 0.261494039995227 0.390358575582966 no 1305 0.396855772536675 419 3122360 SGTC_2580 diallyl disulphide 81.36 µM 0.260147328421918 0.390903024250256 no 1306 0.397375065764585 405 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2518 prenyletin 46.28 µM 0.259607887683452 0.391121169460479 no 1307 0.397583125702924 431 3873459 A coumarin with calcium channel inhibitory activity. SGTC_875 0709-0210 25.7 µM 0.258619799293207 0.391520832734968 no 1308 0.397964302611549 449 6251364 SGTC_86 0417-1630 471.922 µM 0.258549170275568 0.391549405242807 no 1309 0.39799155304898 425 3634867 SGTC_658 3253-0951 102 µM 0.258421573493091 0.391601025171097 no 1310 0.39804078433309 448 1184878 SGTC_825 1988-2224 89.6 µM 0.257791853674002 0.39185580947018 no 1311 0.398283775939794 417 1180859 SGTC_2942 9052777 62.25 µM 0.25711744246391 0.392128727320926 no 1312 0.398544056474783 450 6469503 SGTC_2051 5263410 176 µM 0.256267284148466 0.392472841371339 no 1313 0.398872228697414 421 227584 SGTC_823 0417-1665 178 µM 0.254406268208016 0.393226408029551 no 1314 0.399590854455889 446 3429856 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.25411674738536 0.393343677482422 no 1315 0.399702682707554 412 688801 SGTC_2464 5717415 7.67 µM 0.253693103318595 0.393515290549639 no 1316 0.399866331274117 405 5285744 SGTC_1443 4112-3303 14 µM 0.253282372889776 0.393681692211339 no 1317 0.400025008252282 436 704433 SGTC_10 0279-0212 42.575 µM 0.253154394215722 0.393733544941874 no 1318 0.400074453469427 423 39851 YBR002C RER2 SGTC_2680 butyl paraben 22.24 µM 0.251678775756397 0.394331552686988 no 1319 0.400644681760337 450 7184 An antifungal and steroid mimetic. SGTC_1088 bifonazole 369 nM 0.251613344677343 0.394358075003523 no 1320 0.400669971428954 442 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1920 st075728 45.7 µM 0.251241424607132 0.394508841131042 no 1321 0.400813729606119 456 3400306 SGTC_730 1436-0052 41.2 µM 0.250439497387017 0.394833974030242 no 1322 0.40112374403123 412 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2369 9071472 200 µM 0.249683477269814 0.395140561471305 no 1323 0.401416068405539 417 17296037 SGTC_2426 5582046 32.21 µM 0.248682285202207 0.395546672938137 no 1324 0.401803276403125 407 2251934 SGTC_390 dec-rvkr-cmk 16.7 µM 0.248207557341223 0.395739275494351 no 1325 0.401986909684734 418 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2091 4-phenylthiadiazole 200 µM 0.24627731481326 0.39652265886938 no 1326 0.402733784692939 417 270010 SGTC_325 2810-4341 181 µM 0.246218410059982 0.396546571780964 no 1327 0.402756582497724 429 774970 SGTC_3355 9151058 44.0485 µM 0.245488524598849 0.396842907570195 no 1328 0.403039096213695 424 17015728 SGTC_2587 piperic acid 92.2 µM 0.245470567839649 0.396850198822441 no 1329 0.403046047300096 441 5370536 SGTC_1269 0831-0796 3.05 µM 0.2452320458749 0.396947052892887 no 1330 0.403138382389315 451 927758 SGTC_634 1611-4317 11.2 µM 0.244265666805449 0.397339525127457 no 1331 0.403512536060129 441 2843522 SGTC_512 prima-1 270 µM 0.24382284408325 0.397519401967803 no 1332 0.403684013579243 424 322968 A re-activator of the apoptotic function of mutant p53. SGTC_676 falcarinol 140 µM 0.243508799629799 0.397646981631781 no 1333 0.403805634560022 451 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2791 5663188 71.43 µM 0.243356046316353 0.397709041188529 no 1334 0.403864795177983 471 54690634 SGTC_2702 st077768 96.8 µM 0.242554216701487 0.398034845388411 no 1335 0.404175375942473 402 6484119 SGTC_59 0330-0160 1.33 µM 0.241463043746359 0.3984783314981 no 1336 0.404598127991132 421 4293482 SGTC_2133 5320837 200 µM 0.241277936848326 0.398553577637363 no 1337 0.404669854836798 432 2841355 SGTC_1461 k072-0203 53.8 µM 0.240938875419957 0.398691416226633 no 1338 0.404801245641757 451 5418714 SGTC_1006 4099-6547 255 µM 0.240913204743615 0.398701852637494 no 1339 0.40481119380694 427 3146833 SGTC_1333 1482-0047 286 µM 0.240532209223371 0.398856754838989 no 1340 0.404958848348613 456 3811116 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.240043941383244 0.399055294276986 no 1341 0.405148095981784 432 521171 SGTC_1683 st010134 710 nM 0.239490005698676 0.399280567190038 no 1342 0.405362822656959 425 3818134 SGTC_3346 9158254 43.5805 µM 0.239331712871019 0.399344947410821 no 1343 0.405424188252405 451 17639500 SGTC_2504 purpurogallin 52.29 µM 0.238877288347176 0.39952978432528 no 1344 0.405600368536685 422 5281571 An antioxidant. SGTC_2452 5863136 48.41 µM 0.238875049629191 0.399530694978317 no 1345 0.405601236534508 440 2184096 SGTC_592 k241-0073 46.5 µM 0.238707104818378 0.399599012176582 no 1346 0.405666353576375 449 4230158 SGTC_1230 0170-0365 3.77 µM 0.238116749330252 0.399839183501628 no 1347 0.405895272113529 439 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_673 1082-0474 110 µM 0.238088055519965 0.399850857825204 no 1348 0.405906399357576 450 3098046 SGTC_2532 xanthone 78.9 µM 0.237388928254972 0.400135331406064 no 1349 0.406177539127801 455 7020 An insecticide. SGTC_1460 k062-0059 9.15 µM 0.236688672254166 0.400420317394906 no 1350 0.406449161763627 405 1373085 SGTC_1964 st076914 61 µM 0.236006950302794 0.400697811447355 no 1351 0.406713638470678 456 24208661 SGTC_868 0527-0199 213 µM 0.23489337257959 0.401151199585749 no 1352 0.407145746797699 445 2849450 SGTC_65 0798-0905 34.986 µM 0.234629608850502 0.401258609322541 no 1353 0.407248113216983 464 3602145 SGTC_1332 1480-0653 17.5 µM 0.233975117870796 0.401525163035144 no 1354 0.407502147810954 451 5749438 SGTC_1686 st019653 115.5 µM 0.232165038510324 0.402262590039114 no 1355 0.408204915566928 466 97252 SGTC_997 3996-0078 137 µM 0.232019773194481 0.402321786301733 no 1356 0.408261328015777 431 735687 SGTC_2513 baicalein 25.65 µM 0.231725834101139 0.402441574641382 no 1357 0.408375482373223 440 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2318 6029776 164 µM 0.230443349956259 0.402964329573886 no 1358 0.408873639514452 446 818325 SGTC_2129 girgensonine 121.053 µM 0.229664687072815 0.403281806013905 no 1359 0.409176168536593 472 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1456 k015-0012 13 µM 0.228394427555872 0.403799852993581 no 1360 0.409669810575365 445 2989616 SGTC_688 0527-0193 473 µM 0.228172597034299 0.403890338956759 no 1361 0.409756031979773 448 4007154 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.227815359592523 0.404036069001281 no 1362 0.409894892711159 415 115019 SGTC_282 k297-0036 65.7 µM 0.22702465157944 0.404358674675231 no 1363 0.410202286699921 434 5061378 SGTC_2952 9073731 13.78 µM 0.226965221669971 0.40438292446884 no 1364 0.410225392778898 405 16457353 SGTC_1494 4358-1428 177 µM 0.226341222356289 0.404637563449619 no 1365 0.410468019680331 451 1564571 SGTC_2183 6420625 130.508 µM 0.22572758370795 0.404888013889176 no 1366 0.410706651511896 424 2897619 SGTC_3094 9117742 49.47 µM 0.223722062580112 0.405706818418719 no 1367 0.411486788792292 473 17149698 SGTC_1044 1222-0021 1.78 µM 0.223284693352825 0.405885440369132 no 1368 0.411656969750557 423 4306703 SGTC_2308 7584454 197.62 µM 0.222561617826236 0.406180787966329 no 1369 0.411938355853749 447 893577 SGTC_2358 9037157 4 µM 0.220876406669591 0.40686933667156 no 1370 0.412594334242574 452 2388925 SGTC_639 0833-0042 114 µM 0.216592660330321 0.408620894523117 no 1371 0.414262903088201 460 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_928 2764-0428 58.7 µM 0.215121323049246 0.409222924929218 no 1372 0.414836364839921 461 662578 SGTC_1254 0550-0035 264 µM 0.214285230271088 0.409565126429147 no 1373 0.415162317539033 462 15121435 SGTC_1765 st044815 90.4 µM 0.213653849467279 0.409823587760339 no 1374 0.415408501518896 448 645695 SGTC_775 4577-0580 57.3 µM 0.212113463115389 0.41045432279186 no 1375 0.416009258315837 455 2006902 SGTC_1201 1889-3372 45.9 µM 0.211802104216319 0.410581841711264 no 1376 0.416130713419222 440 5392199 SGTC_2493 resveratrol 26.09 µM 0.210686286866455 0.411038909000663 no 1377 0.416566037961323 451 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1347 1493-0251 600 nM 0.207620436575628 0.412295379764201 no 1378 0.417762672993958 445 3986378 SGTC_1552 6-methylflavone 10.6 µM 0.207286396859441 0.412432333104144 no 1379 0.417893098587397 475 689013 SGTC_2876 9059903 25.97 µM 0.206191798201303 0.412881183539371 no 1380 0.418320547143528 454 6916095 SGTC_1511 0906-3109 28.5 µM 0.205013813282061 0.41336435455164 no 1381 0.418780666403497 432 2882180 SGTC_3121 9125696 49.47 µM 0.203911384459292 0.413816653811155 no 1382 0.419211374239912 477 1235365 SGTC_2477 5967686 25.23 µM 0.203815392721174 0.413856042266191 no 1383 0.419248881835156 435 776118 SGTC_625 k213-0058 121 µM 0.203803874094757 0.41386076878223 no 1384 0.41925338264658 450 3655420 SGTC_1106 tegaserod maleate 11.7 µM 0.202622763849102 0.414345487876071 no 1385 0.419714948042013 446 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1 0258-0098 57.368 µM 0.202515105048067 0.414389676768492 no 1386 0.419757025466282 422 6790032 YDR047W HEM12 SGTC_2972 9093619 59.92 µM 0.202454129866259 0.414414704703738 no 1387 0.419780857446427 393 25236256 SGTC_3148 9097893 49.47 µM 0.202405302300296 0.414434746766767 no 1388 0.419799941776845 422 17174100 SGTC_3331 9141060 1.957 µM 0.202293845648379 0.414480496784202 no 1389 0.419843505489903 433 4906567 YPR165W RHO1 SGTC_2769 toremifene 3.73 µM 0.200801436896713 0.415093202772768 no 1390 0.420426919666673 447 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_145 3737-0113 38.366 µM 0.200563703211736 0.415190823062521 no 1391 0.420519870975407 449 6849351 SGTC_1384 3089-0840 101 µM 0.19699629793777 0.416656327813815 no 1392 0.421915217418421 432 1069836 SGTC_1143 3454-2408 5.08 µM 0.193785344879306 0.41797639240142 no 1393 0.423171981292378 450 X1143 SGTC_871 0574-0004 149 µM 0.193537399896673 0.41807836445579 no 1394 0.423269059408775 471 9551173 SGTC_3045 9092950 49.47 µM 0.193150299840426 0.4182375776694 no 1395 0.423420630345039 447 44120432 SGTC_1922 5578187 25 µM 0.192749140074111 0.418402587740922 no 1396 0.423577718387916 471 1350412 SGTC_1829 berberine 14.4 µM 0.192090919737344 0.418673366294054 no 1397 0.423835493732724 461 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.190601175728886 0.419286359017194 no 1398 0.424419034490903 482 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_575 k072-0246 11.9 µM 0.190039187893893 0.419517654062612 no 1399 0.424639211271544 467 6796779 SGTC_2701 st077767 14.721 µM 0.190021105582973 0.419525096587921 no 1400 0.424646295988351 433 5721188 SGTC_2919 7978188 46.38 µM 0.188664142157683 0.420083693146962 no 1401 0.425178028616886 447 2980291 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.18856897783701 0.420122873774708 no 1402 0.425215324332299 488 1273210 SGTC_2253 7938677 135.83 µM 0.18829554910406 0.420235453031065 no 1403 0.425322487126408 442 2301972 SGTC_837 0091-0265 12.5 µM 0.186829215979428 0.420839299870003 no 1404 0.425897269591156 466 759367 SGTC_1622 st003707 19.4 µM 0.185682579373749 0.421311623188573 no 1405 0.426346845192477 469 10140899 SGTC_3351 9150312 21.596 µM 0.185050266180133 0.421572134555008 no 1406 0.426594804816432 480 4904905 SGTC_2163 5671233 125 µM 0.184146347580103 0.421944606222756 no 1407 0.426949324006962 441 701023 SGTC_979 1426-2828 121 µM 0.183735751855144 0.422113820730962 no 1408 0.427110380211079 468 747872 SGTC_2617 dihydrotanshinone i 20.83 µM 0.183695316790639 0.422130485588081 no 1409 0.427126241525826 451 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1873 rapamycin 2 nM 0.18146838478128 0.423048505043057 no 1410 0.427999973215735 451 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3255 9139072 49.47 µM 0.181162794488327 0.423174512802863 no 1411 0.428119898519987 453 17646060 SGTC_95 0471-0001 561.058 µM 0.180713619279908 0.423359740938122 no 1412 0.428296184078563 436 4015405 SGTC_2119 5528445 120.635 µM 0.179722551743762 0.423768491193659 no 1413 0.428685193992707 471 791935 SGTC_649 1123-0311 367 µM 0.179715893552968 0.42377123753789 no 1414 0.428687807674203 469 693629 YIL048W NEO1 SGTC_2156 5649887 115 µM 0.179711656843047 0.423772985081186 no 1415 0.428689470801847 463 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.178508255999552 0.424269420213256 no 1416 0.429161918988885 464 17037758 SGTC_2778 tioconazole 65.09 nM 0.178071393920364 0.424449667314435 no 1417 0.429333453652308 469 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2199 6590217 200 µM 0.177266177542254 0.42478193692693 no 1418 0.429649658221788 451 703109 SGTC_3002 9075603 71.4286 µM 0.177203250800206 0.424807905673185 no 1419 0.429674371152564 486 20105405 SGTC_1089 terbinafine 2.25 µM 0.175784928450003 0.425393308418889 no 1420 0.430231455306273 450 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_15 0266-0086 27.098 µM 0.175455952317799 0.425529114595559 no 1421 0.430360689394139 479 1712902 YIL048W NEO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.172299821689159 0.426832458361179 no 1422 0.431600912263967 461 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2766 oltipraz 83.91 µM 0.171127265810112 0.427316876990823 no 1423 0.432061848537366 442 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2854 9024559 71.43 µM 0.170757911739477 0.427469491169248 no 1424 0.432207062244827 454 3163529 SGTC_2799 7812892 81.82 µM 0.169473526749125 0.428000273234004 no 1425 0.432712096872772 473 20205235 SGTC_223 busulfan 5 mM 0.168769168363181 0.428291410189447 no 1426 0.432989105244669 469 2478 A DNA alkylator. SGTC_2973 9094665 17.96 µM 0.168707423385937 0.428316933498863 no 1427 0.433013389732665 494 25237061 YIL048W NEO1 SGTC_3217 9129673 49.47 µM 0.168257117681092 0.428503083884504 no 1428 0.433190503984877 429 17248312 SGTC_1002 4049-0206 172 µM 0.161976944438689 0.431100863745919 no 1429 0.43566200488444 469 4662749 SGTC_1109 tnp00067 928.257 nM 0.160063620487502 0.431892904139555 no 1430 0.436415479138946 476 676295 SGTC_3033 9090887 49.47 µM 0.160052555013632 0.431897485607325 no 1431 0.436419837438495 449 19325384 SGTC_2403 6032726 181.2 µM 0.159732972525057 0.432029807150495 no 1432 0.43654571302814 470 2881040 SGTC_3296 9122258 64.045 µM 0.159732545379647 0.432029984013038 no 1433 0.43654588127439 474 4730474 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.159510243121512 0.432122031664585 no 1434 0.436633444398268 476 6708514 SGTC_966 1300-0360 30.2 µM 0.15896781449893 0.432346647990692 no 1435 0.436847115820764 477 70588 SGTC_2448 5185112 27.17 µM 0.158711739173414 0.432452694796527 no 1436 0.436947994446447 440 5718189 SGTC_1754 st042065 16.137 µM 0.15781071864715 0.432825867188366 no 1437 0.437302976120062 469 1126236 YIL048W NEO1 SGTC_1368 1852-0141 284 µM 0.15754477437509 0.432936023826778 no 1438 0.437407761799016 462 2838987 SGTC_1365 1672-3266 55.4 µM 0.157190380468301 0.433082825240606 no 1439 0.437547404665547 486 6415873 SGTC_2155 5570423 76 µM 0.156261959480978 0.433467450964332 no 1440 0.437913269940946 473 797402 SGTC_935 2996-0153 430 µM 0.15593291182892 0.433603783784707 no 1441 0.438042951362197 497 23738523 SGTC_232 clozapine 119 µM 0.155851363847804 0.433637572411829 no 1442 0.438075091378244 481 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2611 pyromycin 23.93 µM 0.154753347679959 0.434092572054623 no 1443 0.438507885590085 451 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2484 5809818 12.04 µM 0.154499007669966 0.434197978805398 no 1444 0.438608146795097 454 2870548 SGTC_118 0083-0097 135.343 µM 0.153020022908968 0.434811010539113 no 1445 0.439191242622671 488 5207356 SGTC_568 1193-0097 7.48 µM 0.15165535956814 0.435376795703424 no 1446 0.439729383858242 455 3646150 SGTC_1136 pergolide 1.05886 µM 0.151452471432715 0.435460923817855 no 1447 0.439809400284402 500 47811 A dopamine receptor agonist. SGTC_395 anisomycin 6.25 µM 0.151423110192471 0.435473098777621 no 1448 0.439820980177147 472 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1382 3002-2117 298 µM 0.150750880902463 0.435751862721718 no 1449 0.440086117342182 488 1497314 SGTC_2989 9073649 71.4286 µM 0.150526470253345 0.435844929746809 no 1450 0.440174634206218 494 21367202 SGTC_1258 0671-0043 57.1 µM 0.15022908158167 0.435968267508364 no 1451 0.440291941234092 463 4298767 SGTC_1570 verbenone 133 µM 0.149810218065738 0.436141995809904 no 1452 0.440457173745367 489 29025 A natural terpanoid with antifungal properties. SGTC_2472 5377652 49.4 µM 0.149719488308329 0.436179628610427 no 1453 0.440492966020805 475 1610903 SGTC_1047 2043-3044 82 µM 0.148396793996891 0.436728319905448 no 1454 0.441014815040163 485 669592 SGTC_2897 9048598 12.99 µM 0.146538662909223 0.437499331057939 no 1455 0.441748085368135 468 6467404 SGTC_1448 4255-0083 152 µM 0.146053563987699 0.437700656740555 no 1456 0.441939551897668 479 5399660 SGTC_1328 1441-0025 69.2 µM 0.145956827078083 0.437740806409023 no 1457 0.441977735177898 458 4562601 SGTC_2754 granisetron 64.02 µM 0.144754369973062 0.438239927351076 no 1458 0.442452405076747 486 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3042 9091578 49.47 µM 0.144564135704276 0.438318899612147 no 1459 0.442527507634929 465 25236497 SGTC_3157 9099274 49.47 µM 0.143766276939304 0.438650142735406 no 1460 0.442842516642223 497 17217662 SGTC_1122 capsaicin 818.572 nM 0.143348513761329 0.438823600589392 no 1461 0.443007471493675 491 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2556 citropten 84.59 µM 0.140698841913754 0.439924032961146 no 1462 0.444053930007003 430 2775 A potential DNA crosslinker. SGTC_1142 3253-1408 9.78 µM 0.140423299606159 0.440038494937213 no 1463 0.444162774907728 482 256655 SGTC_2158 5657123 3.6195 µM 0.140053838522669 0.440191979216191 no 1464 0.444308726272156 493 2858827 SGTC_1372 2752-0194 270 µM 0.139928697125203 0.440243968427727 no 1465 0.444358163659479 484 823334 SGTC_1155 4088-0394 48.2 µM 0.139286344157136 0.440510846151396 no 1466 0.444611940237828 471 2326248 SGTC_2342 7990637 118.86 µM 0.139067994944487 0.440601569633622 no 1467 0.444698209382337 481 2033102 YER133W GLC7 SGTC_253 dyclonine 31.25 µM 0.138379257374756 0.440887758558673 no 1468 0.444970344755492 448 3180 An oral anasthetic. SGTC_1375 2910-0797 186 µM 0.137652305614954 0.441189859993716 no 1469 0.445257607529977 505 742508 SGTC_1437 4092-1038 11.6 µM 0.135397822531848 0.442126978892737 no 1470 0.446148672824095 495 3977136 SGTC_2768 sulfasalazine 50.2 µM 0.135389135743319 0.442130590352004 no 1471 0.446152106732473 471 5384001 An antioxidant and salicylic acid derivative. SGTC_1148 3909-7663 27.7 µM 0.134012264582901 0.442703073558952 no 1472 0.446696438092359 488 4084526 SGTC_1149 3909-7961 23.3 µM 0.133751277292309 0.44281160184329 no 1473 0.446799627995533 498 735261 SGTC_1159 4092-0538 61.2 µM 0.132824548329982 0.443197005050453 no 1474 0.447166069806462 478 717301 SGTC_2412 st077135 33.4 µM 0.130347408724554 0.44422744780251 no 1475 0.448145786625032 487 13258915 SGTC_2327 6189656 200 µM 0.129775301047536 0.444465487526469 no 1476 0.448372102272618 496 5349088 SGTC_280 3448-3607 3.04 µM 0.129609277698025 0.444534569451905 no 1477 0.448437781313285 488 626179 SGTC_2807 7945238 51.95 µM 0.12932698954488 0.444652032755619 no 1478 0.448549458096345 497 17148797 SGTC_2286 7945697 125 µM 0.129264444608774 0.444678059071407 no 1479 0.448574202220464 473 1245733 SGTC_1074 carmofur 3.8 µM 0.128167787323601 0.445134440807448 no 1480 0.449008095888155 488 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1852 st056254 31.4 µM 0.127042636204383 0.445602756039273 no 1481 0.449453326556493 486 442583 SGTC_1190 1486-1332 13 µM 0.126589568427427 0.445791355330453 no 1482 0.449632626852009 502 4150046 SGTC_3238 9133470 49.47 µM 0.126516205911868 0.445821895224181 no 1483 0.449661660829097 489 3534688 SGTC_125 0133-0007 11.75 µM 0.125676518800135 0.446171469272575 no 1484 0.449993994875853 498 26541 SGTC_2 0422-0095 29 µM 0.125071967108129 0.446423178923737 no 1485 0.450233288004428 452 6790840 SGTC_506 n9-isopropylolomoucine 153 µM 0.124702286074341 0.446577109050902 no 1486 0.450379623752659 500 6610355 SGTC_3104 9120930 49.47 µM 0.124606893295418 0.446616830607118 no 1487 0.450417385437727 495 17014836 SGTC_2389 9091542 195.52 µM 0.124526190406815 0.446650435710795 no 1488 0.450449332410385 474 3626624 YOL127W RPL25 SGTC_895 0964-0006 13.7 µM 0.121696061536184 0.447829156716028 no 1489 0.451569866246785 497 6738897 SGTC_786 4544-0069 423 µM 0.121603235043303 0.447867825905015 no 1490 0.451606625656173 464 748821 YLR208W SEC13 SGTC_3010 9080089 71.4286 µM 0.121000180964213 0.448119055158984 no 1491 0.451845445929786 470 17027233 SGTC_91 0417-1751 58.384 µM 0.121000100879342 0.448119088523317 no 1492 0.451845477645996 514 6795624 SGTC_1414 3917-0015 5.4 µM 0.120792375647347 0.4482056306204 no 1493 0.451927744618517 505 6618702 SGTC_622 1348-1566 26.3 µM 0.120476898452506 0.448337068851899 no 1494 0.452052689351282 484 7340407 SGTC_4 0960-0234 25.671 µM 0.11989295643249 0.448580373361137 no 1495 0.452283972090532 451 6821112 SGTC_538 2922-0838 53.3 µM 0.119606696599919 0.448699653074379 no 1496 0.452397357345582 460 777039 SGTC_755 1995-0008 37.3 µM 0.117771283432599 0.44946454895639 no 1497 0.453124441833086 502 689533 SGTC_19 0279-0214 38.434 µM 0.116691020671587 0.449914829059425 no 1498 0.453552453063744 505 3566274 YBR002C RER2 SGTC_1272 0839-0021 27 µM 0.116509249907282 0.449990601941659 no 1499 0.453624477829311 494 5027250 SGTC_1578 josamycin 24.2 µM 0.116480268912324 0.450002683115279 no 1500 0.453635961386713 469 5282165 A P450 substrate. SGTC_3305 9127027 53.8275 µM 0.116341975942424 0.450060333305324 no 1501 0.453690759737393 481 41905295 SGTC_2495 cafestol 54.53 µM 0.11628907869317 0.450082384860218 no 1502 0.453711720414304 483 16667697 An anti-infammatory. SGTC_16 erodoxin 22.806 µM 0.116051321842261 0.450181501713092 no 1503 0.45380593379559 488 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2910 7948405 25.97 µM 0.115633389592444 0.450355738203481 no 1504 0.45397154966573 505 2971328 SGTC_2003 4023581 200 µM 0.114455576986422 0.450846821161413 no 1505 0.454438329671366 486 16641307 SGTC_1315 1237-0019 3.69 µM 0.114022329777223 0.451027480346387 no 1506 0.454610046139725 505 825140 SGTC_89 0302-0250 142.109 µM 0.11382119214974 0.451111355912157 no 1507 0.454689769430122 507 4203518 YLR208W SEC13 SGTC_1847 st056231 15 µM 0.113232635157397 0.451356800142032 no 1508 0.454923061465134 477 5393180 SGTC_2629 bisabolol 100 µM 0.112761739219717 0.451553189917725 no 1509 0.455109726248521 503 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1394 3474-0001 65.7 µM 0.111172398680446 0.45221612052011 no 1510 0.455739819297079 475 5017666 YIL048W NEO1 SGTC_1721 st082152 9.2685 µM 0.111120723612446 0.452237676979267 no 1511 0.45576030772242 475 5296051 SGTC_999 SEC7.066 22.7 µM 0.109438760745671 0.452939390958432 no 1512 0.456427245865795 483 740511 YDR170C SEC7 SGTC_561 1550-0330 72.9 µM 0.109204024031234 0.453037334724332 no 1513 0.456520334342478 492 6812934 SGTC_64 000l-0018 272.079 µM 0.109119138053563 0.453072754055878 no 1514 0.456553997778301 501 6811119 SGTC_1126 isoteolin 1.0172 µM 0.107828796410804 0.453611204907859 no 1515 0.457065749914633 469 133323 SGTC_1712 st032288 53.4 µM 0.106050535501906 0.454353400731094 no 1516 0.457771128344454 494 2883011 SGTC_542 3381-0244 89.3 µM 0.105303276061085 0.454665333410446 no 1517 0.458067581755012 511 1112843 SGTC_1322 1348-1070 12 µM 0.10518123107221 0.45471628199252 no 1518 0.458116001768895 494 6758089 SGTC_583 1488-1091 88.9 µM 0.105151205169796 0.454728816641483 no 1519 0.458127914312424 508 4303273 SGTC_1279 0874-0590 65.2 µM 0.104955255226904 0.45481061924435 no 1520 0.458205656853196 483 3523074 SGTC_2166 5933061 31.504 µM 0.103318253634375 0.455494087672666 no 1521 0.458855194420473 478 2877375 SGTC_1871 st057448 67.3 µM 0.102039428604186 0.456028104714533 no 1522 0.45936268945026 504 691747 SGTC_1205 4161-2785 76 µM 0.101450283292705 0.456274149236834 no 1523 0.459596511021084 468 3498106 SGTC_830 4076-0286 57.8 µM 0.101328202318953 0.456325135965716 no 1524 0.459644964595974 496 6866659 SGTC_3031 9088762 49.47 µM 0.100721685456769 0.456578456441804 no 1525 0.459885698204285 474 205253 SGTC_610 4215-0184 155 µM 0.100363934266379 0.456727884644629 no 1526 0.460027700720756 501 5605015 SGTC_2657 nystatin 74.44 µM 0.0999699850977753 0.45689243936909 no 1527 0.46018407723275 496 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_18 0111-0177 500 nM 0.0995105906125197 0.45708434029476 no 1528 0.460366439772347 491 721752 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0977164606709152 0.457833890098183 no 1529 0.461078722193347 481 6857784 SGTC_1086 cerivastatin 2.18 µM 0.0971684012063714 0.458062887860641 no 1530 0.461296330727514 498 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_269 exalamide 29 µM 0.0968045955195433 0.458214905861392 no 1531 0.461440787190596 499 3316 A derivative of salicylamide. SGTC_417 st075190 100 µM 0.096666209330493 0.458272732818972 no 1532 0.461495737584271 514 222757 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0959774682406065 0.45856054778496 no 1533 0.461769233837559 499 165506 SGTC_776 4476-4378 112 µM 0.0935987681975108 0.459554738370792 no 1534 0.462713944077942 505 2892008 SGTC_1436 4092-1007 8.32 µM 0.0929435106894145 0.459828651504854 no 1535 0.462974219398726 492 2881121 SGTC_820 1582-0060 59.9 µM 0.0928804245824819 0.459855023997738 no 1536 0.462999278716356 483 3848840 SGTC_80 0159-0065 512.242 µM 0.0907939711003175 0.460727343068753 no 1537 0.463828150315411 499 1548079 SGTC_2474 5321570 43.32 µM 0.0901916662214075 0.460979194251052 no 1538 0.464067453364652 517 2841384 SGTC_1052 3253-3998 198 µM 0.0890750843203776 0.461446129476374 no 1539 0.464511119249712 494 5450317 SGTC_31 0508-1974 57.237 µM 0.0889720649937318 0.461489213063713 no 1540 0.464552055479134 504 6810525 SGTC_1776 st049249 45.9 µM 0.0880662004909152 0.461868072959413 no 1541 0.464912030036119 513 1822314 SGTC_2570 licareol 100 µM 0.0875875430852965 0.462068275938345 no 1542 0.465102251651802 494 443158 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0872216926524507 0.462221302818897 no 1543 0.465247648410727 501 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2267 7931562 200 µM 0.0866836924433225 0.462446346171163 no 1544 0.465461469582196 487 934880 SGTC_2621 lithochol-11-enic acid 100 µM 0.0859204248298082 0.462765638593209 no 1545 0.465764837442147 504 6708711 SGTC_1673 st016611 27.3 µM 0.0858078462722791 0.462812734831924 no 1546 0.46580958453187 511 5226799 SGTC_1507 4075-3230 155 µM 0.0848219049844681 0.463225216805758 no 1547 0.466201489318714 503 659771 SGTC_3263 9137018 49.47 µM 0.0837572475605177 0.463670675137132 no 1548 0.466624720015272 519 43844957 SGTC_1642 st009582 77.7 µM 0.0829212205074846 0.464020505261493 no 1549 0.466957090311201 508 6739311 SGTC_1198 1612-1005 86.7 µM 0.0824741832109465 0.464207576564783 no 1550 0.467134823596994 517 6998509 SGTC_1999 st074831 12.5 µM 0.0815882451186601 0.464578337637472 no 1551 0.467487074582725 507 17112523 SGTC_1056 3448-1962 115 µM 0.0806006311976897 0.46499168582459 no 1552 0.467879782108507 504 715507 SGTC_3112 9123419 49.47 µM 0.0803466405411631 0.465097995207703 no 1553 0.467980782151459 515 17015854 SGTC_920 mycophenolic acid 780.421 nM 0.0798863471286895 0.465290660246806 no 1554 0.468163824267941 506 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2533 agelasine 13.65 µM 0.0780804244901832 0.466046643548999 no 1555 0.468882039321271 503 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1108 betulinic acid 729.144 nM 0.0779507554155798 0.466100929500356 no 1556 0.468933612609834 495 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_746 1095-0025 46.6 µM 0.076934216104849 0.466526525404509 no 1557 0.469337938842883 521 6749286 SGTC_2628 lathosterol 100 µM 0.0751442596695015 0.467276021659334 no 1558 0.470049966611818 488 6710616 SGTC_211 3455-0679 143.504 µM 0.0746073885727068 0.467500844775479 no 1559 0.470263547639796 483 748649 SGTC_985 1493-0307 8.71 µM 0.0745541673440905 0.467523132558151 no 1560 0.470284720870293 509 3278274 SGTC_1255 0566-0045 221 µM 0.0743147014546309 0.46762341642661 no 1561 0.470379989654553 515 2788469 SGTC_2885 9057732 51.95 µM 0.072988597146362 0.468178801314787 no 1562 0.470907595733521 500 6471414 SGTC_3274 9138298 49.47 µM 0.07293552961079 0.468201027791191 no 1563 0.4709287103409 481 17015756 SGTC_2212 7123476 200 µM 0.0712455107680338 0.468908916241053 no 1564 0.471601180531515 516 1085715 SGTC_1485 3909-9022 254 µM 0.0701223519004009 0.469379421833115 no 1565 0.472048138123379 517 714516 SGTC_293 4049-0273 38.5 µM 0.0694189553843072 0.469674105434091 no 1566 0.472328070550211 500 1380311 SGTC_1982 st072467 71.9 µM 0.0692809926080895 0.469731906035812 no 1567 0.472382977540484 492 3163533 SGTC_1228 0124-0032 52.5 µM 0.0684178915841658 0.470093523498899 no 1568 0.472726489888486 510 X1228 SGTC_600 1495-0418 41.6 µM 0.0673578811397345 0.470537674739032 no 1569 0.473148399490534 513 5377768 SGTC_936 3005-4620 401 µM 0.0660892268547897 0.47106929723849 no 1570 0.473653393912301 526 777207 SGTC_598 3937-0236 20.2 µM 0.0638356637014086 0.472013766841256 no 1571 0.474550540315265 521 1379313 SGTC_3265 9137266 49.47 µM 0.0626535689918761 0.472509246678766 no 1572 0.475021185642359 516 17224265 SGTC_389 tpck 16.7 µM 0.0620415994556548 0.472765772977265 no 1573 0.47526485210761 489 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_655 k060-0012 42 µM 0.0614650935965579 0.473007443893992 no 1574 0.475494406548821 513 5994525 SGTC_1662 st014054 52 µM 0.061056682047068 0.473178655793131 no 1575 0.475657033734612 520 2838777 SGTC_2026 5148700 152 µM 0.0610465321604754 0.473182910832409 no 1576 0.475661075414218 521 79838 SGTC_184 1494-0393 24.714 µM 0.0606245731224366 0.473359807361197 no 1577 0.475829101496703 513 3090647 SGTC_1221 2958-7315 257 µM 0.0606003685635799 0.473369954720122 no 1578 0.475838739997031 514 4562705 SGTC_275 trichlorophene 5.69 µM 0.0605919458052099 0.473373485825602 no 1579 0.475842094027982 525 62616 SGTC_3252 9135871 49.47 µM 0.0601631096853718 0.473553271205201 no 1580 0.47601286333726 514 17682838 SGTC_2523 spermine 47.74 µM 0.0600643011200983 0.47359469650178 no 1581 0.476052211092674 511 1103 A DNA binding polyamine. SGTC_1619 st003326 88.7 µM 0.0582361025785539 0.474361216191489 no 1582 0.476780281904381 523 2849032 SGTC_2607 solasodine 47.35 µM 0.0581704126576442 0.474388760179404 no 1583 0.476806444039996 516 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1994 st072947 40.9 µM 0.0580874553120577 0.474423544627037 no 1584 0.476839483365937 519 5286565 YDL195W SEC31 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0577038440191375 0.474584397373992 no 1585 0.476992265858002 521 688803 SGTC_2311 7694451 200 µM 0.0563933307889234 0.475133942147947 no 1586 0.477514234880927 527 2163142 SGTC_3154 9100113 49.47 µM 0.0560801645926968 0.47526527090689 no 1587 0.477638972714675 514 25237525 SGTC_644 1498-1197 63.3 µM 0.0556901952619363 0.475428811432175 no 1588 0.477794305214695 512 6741615 SGTC_1420 4'-methoxyflavone 42 µM 0.0553918300517535 0.475553938948594 no 1589 0.47791315226023 525 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_552 k242-0005 476 µM 0.0538070064443232 0.4762186176881 no 1590 0.478544463636532 525 4088318 SGTC_17 0960-0276 49.807 µM 0.0530634952364504 0.476530470952061 no 1591 0.478840658518015 525 6821114 SGTC_216 k038-0035 28.382 µM 0.0530294120704058 0.476544766908528 no 1592 0.47885423661667 506 4444231 YPR107C YTH1 SGTC_956 1185-0240 191 µM 0.0513940959884612 0.477230724457541 no 1593 0.479505744638258 511 1416193 SGTC_1349 flufenamic acid 69 µM 0.0509547606250688 0.477415021764276 no 1594 0.479680784739018 516 3371 A non-steroidal anti-inflammatory. SGTC_1484 3473-2379 286 µM 0.0503753932785829 0.477658068630514 no 1595 0.479911622401607 534 671917 SGTC_2750 bromebric acid 70.15 µM 0.0496639058053177 0.477956551765638 no 1596 0.480195109970745 516 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1156 4092-0367 4.88 µM 0.049427611225397 0.478055684781524 no 1597 0.480289262236485 517 1357585 SGTC_621 3584-0052 32.1 µM 0.0489009145174304 0.478276655510376 no 1598 0.480499130028172 528 2273927 SGTC_334 1502-1024 68.5 µM 0.0486208064632536 0.478394174976345 no 1599 0.480610744206662 526 3296216 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0475045611276635 0.478862514791027 no 1600 0.481055547593744 514 6708561 SGTC_1884 5633444 25 µM 0.0473280362446632 0.478936581513121 no 1601 0.481125891711031 522 5724239 SGTC_2402 5553605 200 µM 0.0471132145407461 0.479026717885617 no 1602 0.48121149767653 517 6758546 SGTC_2116 5511452 16.8835 µM 0.0467688144517682 0.479171225887169 no 1603 0.481348742143128 521 870744 SGTC_459 nigericin 15.3 µM 0.0456239962796674 0.47965160359892 no 1604 0.481804971409405 518 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2274 7947094 46.08 µM 0.0455966399835828 0.479663082952018 no 1605 0.48181587364668 534 2971028 SGTC_1735 st034310 56.75 µM 0.0450648125991265 0.47988625372341 no 1606 0.482027824195896 531 871153 SGTC_458 nppb 133 µM 0.0446247136452083 0.480070937256285 no 1607 0.482203221819121 524 4549 A chloride channel blocker. SGTC_2882 9058044 58.44 µM 0.0441539054891449 0.480268512362536 no 1608 0.482390862141447 515 18076804 SGTC_1250 0485-0349 40.2 µM 0.0439014189672651 0.48037447058004 no 1609 0.48249149211038 524 6842794 YDL195W SEC31 SGTC_1974 st069448 26.9 µM 0.0425918183302439 0.480924078232281 no 1610 0.483013458800042 524 6323587 YNR016C ACC1 SGTC_2982 9019404 25.97 µM 0.042152630685955 0.481108402815386 no 1611 0.483188512102593 495 22333232 SGTC_1429 4049-0205 9.46 µM 0.040992168774757 0.481595461481898 no 1612 0.483651069514324 515 22774478 SGTC_3204 9114183 49.47 µM 0.0395887823474055 0.482184514881849 no 1613 0.484210485409564 529 17027248 SGTC_590 k048-0076 22.4 µM 0.0387134097120414 0.482551961063475 no 1614 0.48455944101025 519 6832814 SGTC_607 4491-0986 66.8 µM 0.0382651040107145 0.482740147502407 no 1615 0.484738156681776 530 698981 YDR232W HEM1 SGTC_2192 5915882 198.485 µM 0.037719051753788 0.482969370455127 no 1616 0.484955842851077 528 2876149 SGTC_2462 5162487 171.77 µM 0.0376520184707208 0.482997510215663 no 1617 0.484982566278843 531 2259986 SGTC_2104 5389443 200 µM 0.0369501083879353 0.483292168629131 no 1618 0.485262393143176 533 2244536 SGTC_3324 9138759 60.749 µM 0.0367513317407987 0.483375615756673 no 1619 0.485341639726212 519 45595710 SGTC_2125 5246583 200 µM 0.0365657784578801 0.48345351232717 no 1620 0.485415615053367 533 835267 SGTC_1111 tnp00062 510.699 nM 0.0359810111644011 0.483699005858835 no 1621 0.485648750022413 525 676306 SGTC_1714 st033236 13.627 µM 0.0344485729377543 0.484342374051231 no 1622 0.486259725416245 532 2916566 SGTC_2555 cholic acid 100 µM 0.0334190125213411 0.484774640523504 no 1623 0.486670224165285 517 6708657 Influences liver metabolism. SGTC_286 k060-0067 22.9 µM 0.0327938459629902 0.485037128825538 no 1624 0.486919492892503 518 5985051 SGTC_167 3672-0051 66.205 µM 0.0325539755470007 0.485137844798346 no 1625 0.487015136275707 532 3237971 SGTC_1300 1094-0077 113 µM 0.0296087749989757 0.4863745408886 no 1626 0.488189533472985 531 5532636 SGTC_2110 5483698 200 µM 0.029297467447716 0.48650526746895 no 1627 0.488313673360381 527 2848765 YHR062C RPP1 SGTC_1948 st076329 66.6 µM 0.0283324228591436 0.486910525317145 no 1628 0.48869851063574 536 24208413 SGTC_291 SEC14.278 35.5 µM 0.0272913696387763 0.487347717139686 no 1629 0.489113670168424 536 1068044 SGTC_1128 3448-9350 235 µM 0.0254426372679293 0.488124132144942 no 1630 0.489850951240936 534 619386 SGTC_1288 0973-0013 65.5 µM 0.0234827189661583 0.488947291166464 no 1631 0.490632611475999 541 4315430 SGTC_3210 9128157 49.47 µM 0.023079086414532 0.489116821427356 no 1632 0.490793593933304 518 17590849 SGTC_1752 st044819 83.042 µM 0.0220373600963462 0.489554367336735 no 1633 0.491209076859891 534 441209 YML126C ERG13 SGTC_2985 9022375 71.43 µM 0.0200981801820505 0.490368894802531 no 1634 0.491982525928753 519 4939335 SGTC_901 1112-0062 60.1 µM 0.0182773109869297 0.491133764007219 no 1635 0.492708813826588 540 1908457 SGTC_1880 MG-132 525 µM 0.0166769180605938 0.491806047583158 no 1636 0.493347180660173 542 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2401 5128683 200 µM 0.0157754960897775 0.492184721952296 no 1637 0.493706748646235 540 708373 SGTC_2684 capsaicin 100 µM 0.0155438149028782 0.492282049028885 no 1638 0.493799164735003 540 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3291 9121177 71.43 µM 0.0148288178247718 0.492582415414345 no 1639 0.494084374403725 538 17015612 SGTC_1211 1056-0033 32.3 µM 0.0147817921545626 0.492602170792011 no 1640 0.494103132875821 542 6741922 SGTC_962 1254-0300 21.5 µM 0.0147346297675527 0.49262198362232 no 1641 0.494121945897147 542 7340576 SGTC_890 0929-0006 47.2 µM 0.0138698162495688 0.492985293335798 no 1642 0.494466921278605 532 1378169 SGTC_1750 st081859 2.357 µM 0.0129312917330411 0.493379575746548 no 1643 0.494841304759265 540 5291695 SGTC_525 k781-2675 26.7 µM 0.0123888417522398 0.493607466732636 no 1644 0.495057693647149 539 3651118 YDL195W SEC31 SGTC_2466 5983409 37.09 µM 0.0117985628890571 0.493855453683375 no 1645 0.495293163619212 532 2879657 SGTC_867 0518-0118 155 µM 0.0117154693654282 0.493890362985883 no 1646 0.495326310847998 540 6848158 SGTC_2405 ticlatone 3.52 µM 0.0117083616111623 0.493893349102175 no 1647 0.495329146237223 515 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_647 0140-0236 81 µM 0.0104893833879511 0.494405472280916 no 1648 0.495815418207624 540 990837 SGTC_3115 9123671 49.47 µM 0.0103733426654943 0.49445422437886 no 1649 0.495861709239425 545 3286988 SGTC_1886 st057356 49.9 µM 0.0101802749116064 0.494535337966452 no 1650 0.49593872806212 542 24207747 SGTC_126 0417-1624 672.48 µM 0.00973463682272191 0.494722564827984 no 1651 0.496116503122563 543 41912 YDL195W SEC31 SGTC_1105 epirubicin 18.1 µM 0.00904358663746424 0.495012899470483 no 1652 0.496392180102378 542 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.00854496618924274 0.495222389218956 no 1653 0.496591093186938 546 94937 An inhibitor of serotonin biosynthesis. SGTC_2809 7964133 12.99 µM 0.00838548082006006 0.495289395476002 no 1654 0.496654716364084 541 1253665 SGTC_1820 st053765 18.6 µM 0.00766037563603593 0.49559404315217 no 1655 0.496943982163602 541 3690829 SGTC_2443 5493264 126.67 µM 0.00764231452198879 0.495601631431583 no 1656 0.496951187294718 541 5340055 SGTC_1540 guanosine 70.6 µM 0.00677613696110462 0.49596555306836 no 1657 0.497296733155655 545 6802 Guanosine is a purine nucleoside SGTC_2364 9055074 200 µM 0.00647924261367078 0.496090293034178 no 1658 0.497415174261857 541 6470630 SGTC_335 4077-0256 27.6 µM 0.00572547225618049 0.496406990845838 no 1659 0.497715879521056 543 3121989 SGTC_2396 5342950 42.78 µM 0.00481879813238054 0.496787934399645 no 1660 0.498077585124284 547 1886677 SGTC_1103 duloxetine 36.1 µM 0.00404382037177471 0.497113547419342 no 1661 0.498386753476116 540 60835 A selective serotonin reuptake inhibitor. SGTC_2336 9001819 198.65 µM 0.00260201838237732 0.497719336850253 no 1662 0.498961946024245 546 2989602 SGTC_1962 st076595 64.5 µM 0.00251600480026521 0.497755476610745 no 1663 0.498996260366474 545 279619 SGTC_185 k048-0037 25.491 µM 0.00200196435562946 0.497971457973708 no 1664 0.499201332308174 547 6827589 SGTC_438 sphingosine 6.67 µM 0.00052907139451958 0.498590317857258 no 1665 0.499788931061222 548 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1268 0828-0275 2.46 µM 1.51184131872312e-05 0.49880626441857 no 1666 0.499993968625767 548 745337 SGTC_67 0335-0847 266 µM -0.00033512531365356 0.498953425805219 no 1667 0.499866304345653 550 4552207 YOR254C SEC63 SGTC_421 streptovitacin 30 mM -0.000867120333712231 0.499176953628674 no 1668 0.499654069080037 553 91467 include heat shock SGTC_1581 himbacine 57.9 µM -0.00134608639414365 0.499378200549438 no 1669 0.499462989386476 552 5281825 An alkaloid muscarinic receptor antagonist. SGTC_465 cgp-37157 41 µM -0.00134654726075287 0.499378394191606 no 1670 0.499462805527466 551 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2271 7849410 118.62 µM -0.00134916862690005 0.499379495610141 no 1671 0.499461759754628 549 972430 SGTC_1340 1486-1359 257 µM -0.00208587817804906 0.499689038771595 no 1672 0.499167855606437 549 4309068 SGTC_2064 5220758 200 µM -0.00221313714541719 0.499742509180422 no 1673 0.499117086741114 551 788518 SGTC_13 0199-0087 65 µM -0.00231901397214435 0.499786995457353 no 1674 0.499074848106888 550 4589825 SGTC_2777 climbazole 1.536 µM -0.00237417579531036 0.499810172807223 no 1675 0.499052841783955 549 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2258 7960471 200 µM -0.00261147684112772 0.499909879622492 no 1676 0.498958172657963 551 2974708 SGTC_222 nsc-310342 10.666 µM -0.00275173057220893 0.499968810056322 no 1677 0.498902219715875 551 432556 SGTC_2332 7982454 138.89 µM -0.00278688150585034 0.499983579430193 no 1678 0.498888196576023 550 2981748 SGTC_2482 5981709 142.65 µM -0.0028650430262797 0.499983579430193 no 1679 0.498857014765342 550 877755 SGTC_762 1165-0429 115 µM -0.00286565856392894 0.499983320799632 no 1680 0.498856769202356 552 5967793 SGTC_791 1348-1292 225 µM -0.00306808099788701 0.499898268931471 no 1681 0.498776014690501 549 5437054 SGTC_368 fentichlor 4.58 µM -0.0032923475294555 0.4998040388307 no 1682 0.498686545741601 550 7329 A pesticide. SGTC_821 1114-0266 29.2 µM -0.00366408447175225 0.499647846092898 no 1683 0.498538245056059 550 3123235 SGTC_981 1488-1094 54.9 µM -0.00371412219861868 0.499626821741193 no 1684 0.498518283027035 549 3449522 SGTC_1127 asiatic acid 681.4 nM -0.00407906813011239 0.499473482444156 no 1685 0.498372691771003 552 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1483 3453-0561 55.9 µM -0.004438228099988 0.499322574309885 no 1686 0.498229408973663 552 4546991 SGTC_1170 0310-0127 64.8 µM -0.00458377295879798 0.499261420797625 no 1687 0.498171345566612 551 774975 SGTC_2317 5986382 200 µM -0.00461045179530646 0.499250211165756 no 1688 0.498160702363202 553 877883 SGTC_1755 st041960 45.185 µM -0.00517417636065849 0.499013351481551 no 1689 0.497935811493928 551 2257073 SGTC_1218 1348-1416 30.7 µM -0.00602004808682167 0.498657942936837 no 1690 0.497598362794406 549 6787668 SGTC_70 0141-0289 43.283 µM -0.00646448671385525 0.49847120429216 no 1691 0.497421060890896 551 352408 SGTC_2283 7944793 200 µM -0.00700541476318734 0.498243924388887 no 1692 0.497205266718214 550 2970533 SGTC_2865 9030313 51.95 µM -0.00724629002220493 0.49814271682755 no 1693 0.497109173833043 552 42562754 SGTC_907 3448-6986 75.5 µM -0.00727819840344971 0.498129310023799 no 1694 0.497096444566343 556 590582 SGTC_2008 4012253 172 µM -0.00736690224944572 0.49809203973138 no 1695 0.49706105780048 551 603940 SGTC_609 0986-0026 86.3 µM -0.00781572861315388 0.497903458657039 no 1696 0.496882007148186 554 2848610 SGTC_3235 9132602 49.47 µM -0.00832383715316095 0.497689969861944 no 1697 0.496679307770866 559 4912240 SGTC_3350 9150499 3.57 µM -0.00994036799601873 0.497010766879461 no 1698 0.496034432230644 555 4910996 YPR165W RHO1 SGTC_1303 1160-0052 261 µM -0.0100694077300466 0.496956549781779 no 1699 0.495982955401347 551 3562476 SGTC_1029 k015-0030 64.7 µM -0.0114922535920245 0.496358733426337 no 1700 0.495415355062391 555 2208316 SGTC_1011 4112-3381 17.4 µM -0.0115591035270932 0.496330646256544 no 1701 0.495388687568185 561 2877139 SGTC_2204 7233102 200 µM -0.0116673114201786 0.496285182474389 no 1702 0.495345521775491 560 2172480 SGTC_3187 9109394 49.47 µM -0.0126291753395025 0.495881055440796 no 1703 0.494961821919092 552 17098090 SGTC_2467 5474540 200 µM -0.0131528262766056 0.495661045300252 no 1704 0.494752932779597 553 5413519 SGTC_147 4466-0538 29.23 µM -0.0133395780043712 0.495582582519799 no 1705 0.494678436155507 571 6742687 YHR072W ERG7 SGTC_3113 9123498 49.47 µM -0.0136830926737499 0.495438257042043 no 1706 0.494541406139037 552 8897275 SGTC_805 3852-0218 479 µM -0.0136890780257282 0.495435742340163 no 1707 0.494539018552688 551 6615355 SGTC_443 clozapine 122 µM -0.0140064396204036 0.495302405448396 no 1708 0.494412421733639 558 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_643 k048-0106 28.4 µM -0.0140719256543457 0.495274892088894 no 1709 0.494386299160417 558 6763920 SGTC_781 4335-2806 94.4 µM -0.0142404964273626 0.495204068720784 no 1710 0.494319055889957 575 845254 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.014396971502556 0.495138327377516 no 1711 0.494256637765699 578 61125 An anti-inflammatory. SGTC_171 k064-0041 9.68 µM -0.0158602049936606 0.49452357197601 no 1712 0.493672958910395 550 53325 SGTC_404 fumagillin 50 µM -0.0167417099703261 0.494153227188062 no 1713 0.493321336036134 553 12015870 A methionine aminopeptidase binder. SGTC_1694 st024011 44.9 µM -0.0174912142242356 0.493838343530872 no 1714 0.49302237090451 565 2787533 SGTC_2227 7312221 64.1025 µM -0.0175901290111098 0.493796787478428 no 1715 0.492982915684047 555 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1987 st072290 61.9 µM -0.0175936810628439 0.493795295192701 no 1716 0.492981498839684 557 54697379 SGTC_2056 5235370 200 µM -0.0177211911403603 0.493741725797311 no 1717 0.492930637608124 560 5511916 SGTC_1860 st056228 74.6 µM -0.0185393925799628 0.493397986623512 no 1718 0.492604276112224 553 688679 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0194183877469332 0.493028712526663 no 1719 0.492253670936512 564 616764 SGTC_1605 st000082 49.1 µM -0.0214479875575 0.492176081999467 no 1720 0.491444146910613 578 1114022 SGTC_1463 k081-0032 34.1 µM -0.0216517637787568 0.492090477956102 no 1721 0.491362870834734 555 977755 SGTC_706 4262-0057 46.9 µM -0.0221080781550588 0.49189878686973 no 1722 0.491180871308067 561 883298 SGTC_2421 5690543 90.72 µM -0.0229691145438414 0.491537083036173 no 1723 0.490837454735107 555 3397993 SGTC_113 0099-0221 2.5 µM -0.0230338249084298 0.491509899808652 no 1724 0.490811645862919 558 89219 SGTC_513 4245-1575 41.7 µM -0.0252649258806294 0.49057269431693 no 1725 0.48992182504394 558 719745 SGTC_1762 st045503 25.4615 µM -0.0258506157022094 0.490326675444531 no 1726 0.489688244913937 563 4645554 SGTC_1727 st034309 9.9045 µM -0.0275243019767695 0.489623664520135 no 1727 0.489020778506707 599 870305 SGTC_1567 st069303 68.4 µM -0.0277705058897222 0.489520252322274 no 1728 0.488922594888395 563 5581319 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0278059465845351 0.489505366344793 no 1729 0.488908461554619 563 2374 Ca(2+)-ATPase inhibitor. SGTC_1176 0848-0131 83.3 µM -0.0294599828008569 0.488810646412379 no 1730 0.48824886708836 562 6769040 SGTC_562 3772-2733 112 µM -0.029468074172467 0.48880724799709 no 1731 0.48824564049897 563 2876874 YIL048W NEO1 SGTC_930 2810-3379 265 µM -0.0297348001786796 0.488695222238271 no 1732 0.48813927882778 583 1015764 SGTC_1870 st057514 26.5 µM -0.0299416031527297 0.488608364954201 no 1733 0.488056813096412 558 5393161 SGTC_2261 9010538 184.68 µM -0.0310264127112846 0.488152753701835 no 1734 0.487624237755891 585 6457250 SGTC_2526 patulin 37.61 µM -0.031359332677017 0.488012933078197 no 1735 0.487491486505068 566 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_440 fluspirilene 35.1 µM -0.0317690183736753 0.487840874200044 no 1736 0.487328126957737 584 3396 An atypical antipsychotic. SGTC_2083 5306046 65.942 µM -0.031813533547177 0.487822178953257 no 1737 0.487310376945014 567 539837 SGTC_347 4534-1311 26.2 µM -0.0333837430766077 0.487162748091439 no 1738 0.486684286791307 560 2862016 SGTC_995 3931-2021 34.6 µM -0.0334772487690323 0.487123480192746 no 1739 0.486647004256421 568 730143 SGTC_1134 3477-0009 42.5 µM -0.0340246813637389 0.486893587319563 no 1740 0.486428734605353 555 3973534 SGTC_2418 pentamidine 31.67 µM -0.0341533125409958 0.486839569625295 no 1741 0.486377447997912 569 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_485 niflumic acid 177 µM -0.0342174043283972 0.486812654851865 no 1742 0.486351894010149 575 4488 A COX2 inhibitor. SGTC_3219 9131112 49.47 µM -0.0353087326139407 0.486354370609541 no 1743 0.485916780027572 564 17612988 YMR079W SEC14 SGTC_1813 st051246 8.6015 µM -0.0354002463882838 0.486315941809748 no 1744 0.485880294123482 564 5291959 SGTC_2783 7738165 71.43 µM -0.0368351589060688 0.485713404926956 no 1745 0.485308220154161 566 17201110 SGTC_1942 st076330 65.2 µM -0.036858270987445 0.485703700151501 no 1746 0.485299006024757 589 24208414 SGTC_1839 st053978 48 µM -0.0373344277663576 0.485503763555339 no 1747 0.485109177615439 566 3788398 SGTC_3166 9102297 49.47 µM -0.0375319263148617 0.485420835659451 no 1748 0.48503044227724 571 25237072 SGTC_3278 9139605 49.47 µM -0.0379949075952729 0.485226436387414 no 1749 0.484845871124243 596 7958859 SGTC_1348 1493-0373 93.8 µM -0.0384406577032075 0.485039275557249 no 1750 0.484668172381857 569 3010129 SGTC_2198 6589944 200 µM -0.0384634674226716 0.485029698337639 no 1751 0.48465907934515 564 5290268 SGTC_2456 5770359 74.46 µM -0.0415388600589605 0.483738500713682 no 1752 0.483433156863927 562 3118787 SGTC_370 0180-0345 38.7 µM -0.0419995489741094 0.483545095721732 no 1753 0.483249528833903 560 3989527 SGTC_124 0136-0217 7.121 µM -0.0421600151958866 0.483477730196871 no 1754 0.483185568725943 569 3976905 SGTC_207 4185-0010 4.486 µM -0.0422590724449518 0.483436145084816 no 1755 0.483146085789098 562 3761753 SGTC_537 1334-0398 209 µM -0.0426527083098855 0.483270895041231 no 1756 0.482989189267441 591 5846986 SGTC_799 1310-0557 151 µM -0.0430243929109781 0.483114862870707 no 1757 0.482841044561569 601 5354492 SGTC_394 menadione 8.33 µM -0.0433058829868019 0.482996695832701 no 1758 0.482728850839187 562 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1167 k781-0610 148 µM -0.043435682344722 0.482942207715623 no 1759 0.482677117066523 578 4525169 SGTC_2671 danthron 100 µM -0.0438536550914783 0.482766750250503 no 1760 0.482510528805995 558 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2616 abietic acid 100 µM -0.0446015131306938 0.482452821204721 no 1761 0.482212468278955 569 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3353 9151644 39.2805 µM -0.0454924885088651 0.482078829881548 no 1762 0.481857381001655 581 4909158 SGTC_2491 paeonol 100 µM -0.0467913620475743 0.481533649629616 no 1763 0.481339756790888 573 11092 Increases levels of cortical cytochrome oxidase. SGTC_1310 1188-0297 994 nM -0.0468620758643827 0.481503969680165 no 1764 0.481311576972034 566 1588352 SGTC_1917 st066507 28.5 µM -0.049456075311323 0.480415290411829 no 1765 0.480277920579928 574 3156428 SGTC_2887 9044784 58.44 µM -0.0505604626163269 0.479951832413344 no 1766 0.4798378843837 574 6465546 SGTC_2648 atorvastatin 78.68 µM -0.0512179355330506 0.479675935622331 no 1767 0.479575930056356 574 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1051 3253-3903 78 µM -0.0520473038023784 0.479327919915007 no 1768 0.479245500741123 560 5509239 SGTC_1672 st016598 6.51 µM -0.052355461617962 0.479198616147798 no 1769 0.479122730946826 617 4665860 YNL267W PIK1 SGTC_764 1951-2361 146 µM -0.0524636325208338 0.479153227892857 no 1770 0.479079636226284 589 5438930 SGTC_164 4100-3994 89.624 µM -0.0527020731229694 0.479053179735822 no 1771 0.478984643605 567 4615967 SGTC_1187 1391-0724 117 µM -0.0528469667664611 0.478992383930724 no 1772 0.47892691984516 578 6997986 SGTC_1481 3346-2004 36 µM -0.0542386903189026 0.478408456886408 no 1773 0.4783724978101 580 2770522 SGTC_3083 9117465 49.47 µM -0.0569090066667864 0.477288200039046 no 1774 0.477308839829931 598 16420915 SGTC_2300 7976697 71.57 µM -0.0583100237597072 0.476700513553687 no 1775 0.47675084164814 570 2236109 SGTC_424 splitomicin 100 mM -0.0587883827874759 0.476499867202442 no 1776 0.476560330824995 605 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_456 gingerol 170 µM -0.0591994474908071 0.476327452024534 no 1777 0.47639662485548 593 442793 A herb. SGTC_2213 7173844 200 µM -0.0593404515721101 0.476268310909763 no 1778 0.476340471084505 569 892728 SGTC_146 3448-8650 53.125 µM -0.0601057740509621 0.475947322087225 no 1779 0.47603569562615 598 2891488 YIL048W NEO1 SGTC_1783 st039459 87.517 µM -0.0602678641521759 0.475879340831423 no 1780 0.475971148047842 567 729761 SGTC_2211 7117706 200 µM -0.0605226203376974 0.475772496458027 no 1781 0.475869700223135 563 822771 SGTC_1212 0520-0165 585 µM -0.0636548422162512 0.474458991895882 no 1782 0.474622531236099 602 5403258 SGTC_2959 9079155 11 µM -0.0653407561865298 0.473752113936849 no 1783 0.473951346457412 577 16189457 SGTC_210 3551-0445 56.827 µM -0.0655962248074308 0.473645007003787 no 1784 0.473849647404536 585 2865180 YOR207C RET1 SGTC_736 0958-0254 92.6 µM -0.0657770471498588 0.473569197174753 no 1785 0.473777665186696 583 6812352 SGTC_1096 rimcazole 32.2 µM -0.0697954254184331 0.471884742701396 no 1786 0.472178244143717 605 18528119 A dopamine reuptake inhibitor. SGTC_558 k064-0027 21.3 µM -0.0698836227122813 0.471847777015226 no 1787 0.472143144219639 584 5088526 SGTC_833 3852-0053 558 µM -0.0708905566881999 0.47142576313265 no 1788 0.471742429569234 588 3123681 SGTC_879 0831-1030 162 µM -0.0708908129820106 0.471425655721979 no 1789 0.471742327579393 578 1549252 SGTC_1969 st069479 40.1 µM -0.0711337106940232 0.471323860183488 no 1790 0.471645669431017 585 3895485 SGTC_1406 3909-7906 11.9 µM -0.0712050492264493 0.471293963409726 no 1791 0.471617281459014 582 X1406 SGTC_2594 a-mangostin 100 µM -0.071349810587994 0.471233296866045 no 1792 0.47155967654746 581 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1661 st013063 9.66 µM -0.0730535513498509 0.470519344287774 no 1793 0.470881751748455 596 721395 SGTC_994 3910-0338 138 µM -0.074120873154002 0.470072131204255 no 1794 0.470457103284229 577 3479481 SGTC_387 norethindrone acetate 66.7 µM -0.0753538333560331 0.469555561842129 no 1795 0.469966595183989 604 541197 SGTC_2141 5621638 7.665 µM -0.0756590360754856 0.469427699920276 no 1796 0.469845183506783 592 2856238 SGTC_1070 indatraline 8.81 µM -0.0774345371850307 0.468683932708363 no 1797 0.469138933276697 589 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_922 1866-0035 480 µM -0.077516310244143 0.468649680135329 no 1798 0.469106408307266 618 3156169 SGTC_1353 1498-1206 8.11 µM -0.0775170376027778 0.468649375465064 no 1799 0.46910611900365 584 6756808 SGTC_2070 5230947 200 µM -0.0788429430191253 0.46809402133137 no 1800 0.468578773374322 609 2835538 SGTC_302 1094-0063 18.9 µM -0.080275070906721 0.467494245802989 no 1801 0.46800924237462 575 5440289 SGTC_122 0236-0016 402.397 µM -0.0804982261168837 0.467400794953835 no 1802 0.46792050350594 583 6808838 SGTC_523 1934-0222 13.7 µM -0.0808052661835871 0.467272218527821 no 1803 0.467798409979608 600 1361595 SGTC_2172 5754775 163.918 µM -0.0814706874142736 0.46699357776044 no 1804 0.467533817710875 585 2263357 SGTC_788 1182-0090 188 µM -0.0816739063364345 0.466908484390118 no 1805 0.467453014372798 584 5715185 SGTC_392 N-ethylmaleimide 8.33 µM -0.0822816119262927 0.466654030329824 no 1806 0.46721138819488 583 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1554 st069299 38.7 µM -0.0824597798407695 0.466579431736691 no 1807 0.467140550204428 579 24207999 SGTC_3027 9089541 49.47 µM -0.0827227687473505 0.466469320889255 no 1808 0.467035990038563 596 9943819 SGTC_1654 st012436 41.8 µM -0.0833285784766289 0.466215684141583 no 1809 0.466795138486046 594 4323132 SGTC_483 fpl-64176 144 µM -0.0835674273043064 0.466115688126777 no 1810 0.466700182781828 587 3423 SGTC_2739 tacrine 100.86 µM -0.0839158036926911 0.465969841340134 no 1811 0.466561687175231 587 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_958 1222-0007 33 µM -0.0845086186351501 0.465721671562006 no 1812 0.466326025338029 600 7312461 SGTC_120 rhodamine 6G 52.259 µM -0.0847584195639872 0.465617101529239 no 1813 0.466226725457894 581 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3029 9088683 49.47 µM -0.0848113972687109 0.465594924653501 no 1814 0.466205666239646 591 25236615 SGTC_2001 4023502 57.655 µM -0.0852237614651359 0.465422309478755 no 1815 0.466041750191347 584 108941 YCR052W RSC6 SGTC_876 0720-0963 56.8 µM -0.0863299705090085 0.464959283879489 no 1816 0.465602057192294 596 765861 SGTC_203 k066-0004 30.888 µM -0.0871283799044126 0.46462512333128 no 1817 0.465284733628832 575 6795412 SGTC_1496 4469-0713 57.4 µM -0.0879997780273575 0.464260443085346 no 1818 0.464938426283856 614 746691 SGTC_1471 k673-0312 37 µM -0.0890412306999371 0.463824634393362 no 1819 0.464524571437291 579 24099884 SGTC_3348 9149464 3.537 µM -0.0892282690399791 0.463746370479814 no 1820 0.464450249765679 584 1951442 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0901274233556691 0.463370149953367 no 1821 0.464092978604826 588 688788 SGTC_756 0508-1999 28.3 µM -0.090876161189927 0.463056891066835 no 1822 0.463795496206587 597 6753853 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0921344591890268 0.462530492766442 no 1823 0.463295605202459 582 5355888 SGTC_201 4262-0159 12.803 µM -0.0924431480575619 0.462401365382733 no 1824 0.463172979490615 576 1341029 SGTC_341 1486-1430 230 µM -0.0933577932640885 0.462018784223284 no 1825 0.462809660060108 600 2054753 YPL210C SRP72 SGTC_1670 st016595 4.04 µM -0.0945577942207416 0.461516896760319 no 1826 0.462333037448645 582 597879 SGTC_1025 k007-0731 70 µM -0.0946334584467793 0.46148525305894 no 1827 0.462302986543748 578 6256118 SGTC_2024 5144227 134 µM -0.0951657720531437 0.461262639925007 no 1828 0.462091578253644 590 3475211 SGTC_2251 lansoprazole 556 µM -0.0954493134514448 0.461144068083938 no 1829 0.461978974186213 624 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_116 0155-0182 31.788 µM -0.0955123899775795 0.46111769110051 no 1830 0.461953924736496 593 771486 SGTC_2200 6600604 21.907 µM -0.0959031342683334 0.460954295688828 no 1831 0.461798752635367 611 2904777 SGTC_229 benomyl 22.8748 µM -0.0959601673577581 0.460930447023108 no 1832 0.461776104180281 599 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_814 3342-0569 96 µM -0.0984460214580756 0.459891112665646 no 1833 0.460789066147127 582 4346283 SGTC_115 0527-0192 112.043 µM -0.0987714875208936 0.45975505560174 no 1834 0.460659853714599 607 4233931 SGTC_2207 7258803 200 µM -0.0988737776791244 0.459712295438269 no 1835 0.460619244622968 594 3666799 SGTC_2765 myclobutanil 7.74 µM -0.0995494974515919 0.459429837295964 no 1836 0.460350994879344 592 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2009 4012297 12.05 µM -0.100001350407766 0.459240969309892 no 1837 0.460171626675204 618 45595307 SGTC_1007 4101-0031 70 µM -0.101016883005079 0.458816525038119 no 1838 0.459768529015944 636 1146276 SGTC_304 1310-0298 97 µM -0.101604732543978 0.458570853342595 no 1839 0.459535211433197 589 1550234 SGTC_2689 tacrolimus 100 µM -0.102116048365973 0.458357179171813 no 1840 0.459332281424937 588 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_665 3914-0008 307 µM -0.102892186566382 0.458032861184054 no 1841 0.459024269502157 614 1069549 SGTC_3064 1327-0027 10 µM -0.103596766133165 0.457738468956075 no 1842 0.458744677053836 586 16000455 YPR107C YTH1 SGTC_2751 anetholtrithion 17.25 µM -0.103599952415465 0.457737137694468 no 1843 0.458743412714185 608 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_273 hydroxyurea 18.1 mM -0.10401844464841 0.45756229144987 no 1844 0.458577355629114 591 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2112 5488546 200 µM -0.106379143764204 0.456576145101162 no 1845 0.457640770018067 607 600757 SGTC_3052 9092717 49.47 µM -0.106739493541563 0.456425637804068 no 1846 0.457497825126722 612 25237534 SGTC_270 tamoxifen 5.46 µM -0.107025110684175 0.456306348527742 no 1847 0.457384529360215 581 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_801 0866-0028 10.1 µM -0.109705867887149 0.455186911688099 no 1848 0.456321323304355 583 6849771 SGTC_2920 7982904 15.77 µM -0.110014831877155 0.455057916479888 no 1849 0.456198806089745 603 6456808 SGTC_2378 9074213 121.43 µM -0.110550436698819 0.4548343079482 no 1850 0.455986426128306 579 657714 SGTC_2866 9034245 58.44 µM -0.110901592839213 0.454687712271521 no 1851 0.455847191246315 617 6462273 SGTC_197 4544-0043 41.561 µM -0.111569897521331 0.454408734992223 no 1852 0.455582220631216 596 896523 SGTC_601 0986-0029 62.9 µM -0.11183639691185 0.454297493682014 no 1853 0.455476563987747 604 24747981 SGTC_2517 totarol 10 µM -0.111905098090721 0.454268817239837 no 1854 0.455449327152524 592 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_945 3381-0768 11.3 µM -0.111917501631738 0.454263639924285 no 1855 0.455444409745347 603 1126236 YIL048W NEO1 SGTC_1561 5-methoxyflavone 52.9 µM -0.112777021134469 0.453904890086623 no 1856 0.455103668288658 585 94525 SGTC_365 0121-0052 13.6 µM -0.113939474651797 0.453419760262113 no 1857 0.454642886532651 600 3101739 SGTC_1668 st014914 51.6 µM -0.11446617975691 0.453199971853824 no 1858 0.454434127395909 587 2839556 SGTC_1291 0993-0025 5.79 µM -0.115021235970901 0.45296836834585 no 1859 0.454214144941613 611 4353356 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.115752324917498 0.452663337607326 no 1860 0.453924417819843 587 6708630 An antioxidant. SGTC_1830 st055982 50.3 µM -0.118048051168213 0.451705678863495 no 1861 0.453014792348569 630 455313 An antimicrobial agent. SGTC_488 nitrendipine 139 µM -0.118407652494442 0.451555697022886 no 1862 0.452872331311297 591 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2354 9060492 162 µM -0.120897893572694 0.450517262875041 no 1863 0.451885955309568 614 6471895 SGTC_180 1486-1293 102.781 µM -0.122158930260926 0.449991537460332 no 1864 0.451386575846315 624 4140536 SGTC_595 3909-8003 73.7 µM -0.122402050258572 0.449890190945073 no 1865 0.451290307425096 608 699517 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.123045841193298 0.44962183734808 no 1866 0.451035398862132 618 390807 SGTC_1360 1598-0022 39.8 µM -0.123142460027493 0.449581565371206 no 1867 0.450997144443453 626 761525 SGTC_1183 1254-0324 198 µM -0.123607719645599 0.449387646437036 no 1868 0.450812939986498 605 5799357 SGTC_1980 st071811 45.7 µM -0.124781867348886 0.448898318737595 no 1869 0.450348121470445 621 4974850 SGTC_860 0443-0016 25.1 µM -0.124912755541714 0.448843775701149 no 1870 0.450296310002721 606 5337942 SGTC_1771 st048882 4.1505 µM -0.125054001271533 0.448784917611201 no 1871 0.450240399503626 605 4580403 SGTC_330 1488-0319 80.1 µM -0.125459024895708 0.448616147670242 no 1872 0.450080081035984 597 6846614 SGTC_1573 oleylamine 1.06 µM -0.126150993980575 0.448327831496393 no 1873 0.449806201248986 619 5356789 An amine of the fatty acid oleic acid. SGTC_1525 8-methoxypsoralen 92.5 µM -0.126154946163372 0.448326184856234 no 1874 0.449804637052579 640 4114 Related to psoralen; DNA damaging agent. SGTC_2185 6113692 200 µM -0.12644922355609 0.44820357942392 no 1875 0.449688170027072 612 874150 SGTC_2457 5731572 11.68 µM -0.126808130773167 0.448054053824722 no 1876 0.449546130133697 626 2865357 SGTC_2831 7999036 19.48 µM -0.127056954459799 0.447950394843386 no 1877 0.44944766031531 637 2988270 SGTC_2098 5376439 882.5 nM -0.127152813592581 0.447910461249035 no 1878 0.449409725724292 610 2844116 SGTC_760 0568-0725 82.9 µM -0.129969691156863 0.446737226232391 no 1879 0.448295203105525 603 3916171 SGTC_2244 6635614 200 µM -0.130280550496056 0.446607781076124 no 1880 0.448172233684659 590 836499 SGTC_265 mycophenolic acid 32.932 µM -0.130421190037424 0.44654921913398 no 1881 0.448116601273597 596 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1290 0986-0249 10.2 µM -0.132495980799245 0.445685417733517 no 1882 0.447296000928464 615 53329 SGTC_2593 nobiletin 86.24 µM -0.13311560793263 0.445427497043496 no 1883 0.447050975826834 603 72344 An anti-infammatory. SGTC_3030 9087619 49.47 µM -0.134126322566584 0.445006835227208 no 1884 0.446651342652645 602 25236973 SGTC_2176 5809774 33.9695 µM -0.134935284382929 0.444670188000355 no 1885 0.446331520877221 631 2870539 SGTC_306 1672-3436 11.6 µM -0.134993872123608 0.444645808420647 no 1886 0.446308359659748 607 6797378 SGTC_1967 st070177 51.4 µM -0.135603706645021 0.444392056019806 no 1887 0.446067287522262 624 5729214 SGTC_1811 st050069 61.5 µM -0.137069355195679 0.443782292445789 no 1888 0.445487987408601 607 3877702 SGTC_836 0330-0104 1.35 µM -0.138258741165917 0.443287561983088 no 1889 0.445017966032174 601 46494820 SGTC_96 0929-0093 37.281 µM -0.138527080996209 0.443175957012955 no 1890 0.444911934198611 612 6991579 SGTC_1249 0481-0015 10.2 µM -0.141956172811773 0.441750166505035 no 1891 0.443557312022212 601 4227577 SGTC_1745 st081495 74 µM -0.141993162139543 0.441734790701318 no 1892 0.44354270339154 601 13842402 YBL026W LSM2 SGTC_2077 5212015 200 µM -0.142407740793699 0.441562463762173 no 1893 0.443378974216866 598 780900 SGTC_2927 9011802 47.9 µM -0.144368927073392 0.440747412520028 no 1894 0.442604576167893 620 43912568 SGTC_766 1391-0721 126 µM -0.14553885235596 0.440261321452322 no 1895 0.442142721273387 659 1020919 YIL115C NUP159 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.146101110728611 0.440027741274295 no 1896 0.441920784796128 611 368090 SGTC_1324 1418-0026 34.4 µM -0.147416308805177 0.439481447421722 no 1897 0.44140171679463 641 1372513 SGTC_2932 9016711 44.54 µM -0.149425001725045 0.438647319325441 no 1898 0.440609142334112 638 7117328 SGTC_11 0438-0307 1.3 µM -0.15009321586716 0.438369897500107 no 1899 0.440345536153981 620 4011476 SGTC_1067 clotrimazole 1.36 µM -0.152679445902587 0.437296461460857 no 1900 0.43932553524909 601 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2440 5628896 157.78 µM -0.153933247218075 0.436776226489487 no 1901 0.438831184515186 613 5522048 SGTC_2108 5365811 200 µM -0.155165797456103 0.436264915697342 no 1902 0.438345305674536 601 780283 SGTC_1784 st039334 36.3 µM -0.156950028712064 0.435524934573918 no 1903 0.437642115598438 614 3496984 SGTC_1618 st003135 44.5 µM -0.157020789810292 0.435495592186186 no 1904 0.437614231721149 614 1270615 SGTC_2983 9022671 12.99 µM -0.157894996980336 0.435133115487808 no 1905 0.437269770221895 666 6405161 SGTC_3194 9111903 49.47 µM -0.157919262690921 0.435123054856257 no 1906 0.437260209546212 633 17087251 SGTC_3289 9119912 71.43 µM -0.158104846601499 0.435046112636676 no 1907 0.437187090806684 664 17014829 SGTC_1936 st074407 74.3 µM -0.158457879660667 0.434899753576529 no 1908 0.437048004219113 604 809813 SGTC_2792 7535235 81.82 µM -0.158731770134598 0.434786211282179 no 1909 0.436940103277299 612 1281891 SGTC_2485 5633444 17.78 µM -0.158805408233401 0.434755685256845 no 1910 0.436911093866934 614 5724239 SGTC_1732 st034308 51.822 µM -0.159424105560778 0.434499225107285 no 1911 0.436667374145816 600 830119 SGTC_377 3970-0964 33.1 µM -0.159509282658163 0.434463919964894 no 1912 0.436633822724022 607 16481235 SGTC_1031 k035-0009 16 µM -0.159646011595231 0.434407248140614 no 1913 0.436579965887112 664 5180959 SGTC_2249 haloperidol 116.36 µM -0.159678729284443 0.434393687413432 no 1914 0.436567078729048 628 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1768 st044301 37.178 µM -0.160334585217012 0.434121866568542 no 1915 0.436308758107132 623 3931349 SGTC_629 3448-6466 76.7 µM -0.160449614631611 0.434074195597029 no 1916 0.436263454505834 639 573744 SGTC_2873 9040596 71.43 µM -0.162059354095485 0.433407181527777 no 1917 0.435629556873331 638 6463863 SGTC_1691 st019933 84.6 µM -0.162168208714505 0.433362083187934 no 1918 0.435586697076542 628 6176082 SGTC_1700 st030840 7.9285 µM -0.162285851752494 0.433313344792128 no 1919 0.43554037782849 612 5499307 SGTC_3299 9121982 43.1275 µM -0.163226784716601 0.43292356173775 no 1920 0.435169938928297 635 17594604 YPL160W CDC60 SGTC_1049 3226-0134 66 µM -0.163722008776819 0.432718440527088 no 1921 0.434974995418214 602 5702385 SGTC_1689 st020265 53.493 µM -0.164098383169881 0.432562558827571 no 1922 0.434826847301919 641 5758320 YPR016C TIF6 SGTC_3107 9121808 49.47 µM -0.164266959723199 0.432492743452756 no 1923 0.434760495331358 616 662681 SGTC_353 1988-1175 58.3 µM -0.165750501077078 0.431878431249686 no 1924 0.434176650789313 629 2788357 SGTC_1877 wortmannin 25 µM -0.166202472123899 0.431691309485732 no 1925 0.433998807016595 632 312145 A covalent inhibitor of PI 3-kinase. SGTC_374 0880-0231 82.3 µM -0.167310419310053 0.431232670172677 no 1926 0.433562903136206 634 6833587 SGTC_2516 gossypol 71.55 µM -0.167681750630239 0.431078976750946 no 1927 0.433416826892529 646 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1836 st055642 81 µM -0.167895573139905 0.430990480699819 no 1928 0.433332716408201 645 8571 SGTC_450 aminopyrene 156 nM -0.169356594766359 0.430385891541684 no 1929 0.432758081316374 615 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_237 nikkomycin 200 µM -0.16939145821995 0.430371466592792 no 1930 0.432744370887268 642 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_123 0083-0120 66.675 µM -0.169716012999073 0.430237184699192 no 1931 0.432616740107745 621 16001701 SGTC_784 4579-0127 173 µM -0.170176766323899 0.430046565628026 no 1932 0.432435561489975 664 1948547 SGTC_2855 9016525 58.44 µM -0.170359407031353 0.429971009528328 no 1933 0.432363746966639 634 43811474 SGTC_1152 3909-8331 15.9 µM -0.170414537313058 0.429948203347192 no 1934 0.432342070119281 632 16001939 SGTC_340 k038-0059 454 µM -0.171226665673761 0.429612270884672 no 1935 0.432022770467701 612 23733424 SGTC_303 1348-1668 34.2 µM -0.171924497436522 0.429323657282615 no 1936 0.431748443583553 627 5380509 SGTC_2231 micatex 6.853 µM -0.172488689076609 0.429090343003605 no 1937 0.431526676450813 626 20737 An antifungal of unknown mechanism. SGTC_2540 epiandrosterone 100 µM -0.172513617289527 0.429080034828974 no 1938 0.431516878401131 626 441302 A steroid. SGTC_2341 7987486 176.74 µM -0.175214132874738 0.427963620678439 no 1939 0.430455689843384 621 1258686 SGTC_569 4130-2812 160 µM -0.175968108567333 0.427652023810992 no 1940 0.430159498566133 649 743552 SGTC_892 0929-0076 29 µM -0.176416930407814 0.427466559826014 no 1941 0.429983202359276 611 5751038 SGTC_2016 5121758 140 µM -0.17699109338035 0.427229325241253 no 1942 0.429757692793152 639 2795203 SGTC_1779 st039427 55 µM -0.177083767686871 0.427191036224309 no 1943 0.429721295965929 637 1124498 SGTC_1564 D-Arginine 115 µM -0.177673055566417 0.426947584010303 no 1944 0.429489873539486 666 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2437 5741531 144.16 µM -0.178184803484398 0.426736188411937 no 1945 0.429288921903855 626 2262990 SGTC_3309 9129340 25.759 µM -0.179304127719569 0.42627388532927 no 1946 0.428849452963154 618 17158987 SGTC_1945 st075991 56.6 µM -0.179858686531794 0.426044879037617 no 1947 0.428631754789659 634 1084980 SGTC_1846 st056244 14.8 µM -0.180942591623154 0.42559735009929 no 1948 0.42820631865233 652 5393182 SGTC_415 dibenzyl ketone 100 µM -0.181799260418483 0.425243711555981 no 1949 0.427870132475284 641 7593 SGTC_1919 st067113 52.3 µM -0.182990163863707 0.424752198710256 no 1950 0.427402868203592 640 1268243 SGTC_3232 9132874 49.47 µM -0.183973277234537 0.424346533639176 no 1951 0.427017209379983 657 3784940 SGTC_2046 4110841 106 µM -0.184046189302941 0.424316450896419 no 1952 0.426988609976845 653 44119630 YMR134W ERG29 SGTC_212 3807-4682 38.772 µM -0.185463772163202 0.423731659136762 no 1953 0.426432646460744 624 3125501 YBL034C STU1 SGTC_949 1165-0505 146 µM -0.18593172591722 0.423538652199149 no 1954 0.426249151151252 628 6244267 SGTC_1188 1403-0014 4.57 µM -0.187501784067598 0.422891217968852 no 1955 0.425633612505959 616 9614867 SGTC_1393 3470-5649 58.2 µM -0.18763231730497 0.42283740021404 no 1956 0.425582445308419 636 4108395 SGTC_3254 9136651 49.47 µM -0.188022718949492 0.42267644950097 no 1957 0.425429420823717 626 16454030 SGTC_3093 9117344 49.47 µM -0.189729180645505 0.421973079156538 no 1958 0.424760676634103 627 24824913 SGTC_2716 st080858 38.6235 µM -0.189814168338583 0.421938055367302 no 1959 0.424727376504766 622 5296050 SGTC_896 0964-0007 44.5 µM -0.189887835929745 0.421907697139644 no 1960 0.42469851228587 622 6756758 SGTC_1876 myriocin 605 nM -0.19079773464863 0.421532768500892 no 1961 0.424342031785485 641 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.191544891758147 0.421224951579844 no 1962 0.424049356517927 626 3256 An antibiotic and ribosome inhibitor. SGTC_233 rapamycin 362 pM -0.191729881186455 0.421148746287077 no 1963 0.423976899197798 624 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_462 ag-879 158 µM -0.192081085478765 0.421004077901153 no 1964 0.423839345318732 648 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1626 st003712 1.76 µM -0.192612501564775 0.420785196797678 no 1965 0.423631226717623 664 24207035 SGTC_3087 9117406 49.47 µM -0.193422771643461 0.420451507704918 no 1966 0.423313941484289 624 42546093 SGTC_630 4356-0227 183 µM -0.194192176587592 0.420134700780344 no 1967 0.423012704225089 655 779312 SGTC_944 3370-0224 231 µM -0.194557556744451 0.41998427149934 no 1968 0.422869666414609 642 4580514 SGTC_1076 itraconazole 331 nM -0.194965742456135 0.419816232729965 no 1969 0.422709883252927 622 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2717 st081029 62.2815 µM -0.195022338823302 0.419792934724019 no 1970 0.422687729765555 673 5292846 SGTC_1524 corynanthine 62.1 µM -0.195574000443573 0.419565856868556 no 1971 0.422471805954552 679 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.195753272491437 0.419492069728235 no 1972 0.422401642764958 611 4000243 SGTC_1280 0880-0253 10.1 µM -0.19583109717298 0.419460038506301 no 1973 0.422371184639603 663 6836607 SGTC_933 2914-0560 114 µM -0.196649713652028 0.419123143239445 no 1974 0.422050832128648 643 463887 SGTC_947 3447-0010 211 µM -0.197652762687157 0.418710427038556 no 1975 0.421658375199566 651 748350 SGTC_917 harmaline 728.087 nM -0.197820635764013 0.418641362433666 no 1976 0.421592700105785 633 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2372 9071633 200 µM -0.198186891935933 0.418490689814645 no 1977 0.421449421399559 605 21321366 SGTC_3282 9108498 15.4605 µM -0.198783252235341 0.418245381203122 no 1978 0.421216148664849 655 16459645 SGTC_3000 9075062 71.4286 µM -0.198933387234332 0.418183629234514 no 1979 0.421157426101751 601 17057871 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.200540578943911 0.417522702481285 no 1980 0.420528912551515 619 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3315 9136395 68.55 µM -0.200757235595746 0.41743362436622 no 1981 0.420444201563339 681 16876844 SGTC_2097 5376186 200 µM -0.201629584816168 0.417075001982893 no 1982 0.42010315743822 636 742755 SGTC_2676 harmalol 100 µM -0.202874374566696 0.416563388978673 no 1983 0.419616611952642 627 5459187 A monoamine oxidase inhibitor SGTC_1591 genipin 88.4 µM -0.203156981608494 0.41644725613299 no 1984 0.419506167669519 630 442424 A DNA cross-linking agent. SGTC_468 gf-109203x 121 µM -0.204043534809164 0.416082988638738 no 1985 0.419159739311398 648 2396 A protein kinase C inhibitor. SGTC_266 formosanin C 406 nM -0.20451282509405 0.415890195528125 no 1986 0.418976385406482 646 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_88 0180-0332 8.668 µM -0.204558661320031 0.415871366244774 no 1987 0.418958477921688 631 3101745 SGTC_2194 5927483 104.545 µM -0.205857385563841 0.415337937495036 no 1988 0.418451156919462 631 760979 SGTC_2215 7188065 200 µM -0.206059438347911 0.415254961771898 no 1989 0.418372241155709 646 940217 SGTC_969 1313-0238 134 µM -0.207020608703382 0.414860295910606 no 1990 0.417996881855364 633 5212874 SGTC_2595 hexamethylquercetagetin 100 µM -0.207102007452282 0.414826876736111 no 1991 0.417965097182856 676 386331 SGTC_679 0422-0091 41.4 µM -0.207983850941634 0.414464865505116 no 1992 0.417620788360998 629 627384 YHR062C RPP1 SGTC_2722 naftopidil 47.16 µM -0.208887567341592 0.41409395045489 no 1993 0.417268004948558 675 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_515 4092-1064 102 µM -0.20909406781229 0.414009206584602 no 1994 0.417187402778255 696 717353 SGTC_1900 st060200 72.8 µM -0.209435696577897 0.413869017422114 no 1995 0.417054064381483 624 688945 SGTC_3344 9148862 3.898 µM -0.209528713203381 0.413830849460463 no 1996 0.417017761456532 674 4905352 SGTC_1204 4049-0315 18.3 µM -0.210198442215005 0.41355606036871 no 1997 0.416756397669054 645 588402 SGTC_710 3448-4187 58 µM -0.213192166925034 0.412328257698903 no 1998 0.415588538860909 634 3946412 SGTC_560 2332-1943 155 µM -0.213258454717882 0.412301081048581 no 1999 0.415562688237674 636 21177716 SGTC_1885 st057546 99.9 µM -0.213309925948746 0.412279979178112 no 2000 0.415542615964446 635 702008 SGTC_3277 9138724 49.47 µM -0.214008004612828 0.411993810087627 no 2001 0.415270407505387 638 15943418 SGTC_1983 st071813 46.9 µM -0.21483130165747 0.411656369350397 no 2002 0.414949423719476 656 11838595 SGTC_1845 st056753 3.01 µM -0.21807009638611 0.410329536650676 no 2003 0.41368724816712 639 5375839 SGTC_2459 5811157 9.22 µM -0.218349894164216 0.410214960189639 no 2004 0.413578251120802 634 2870684 YBR192W RIM2 SGTC_1326 1431-2094 10.8 µM -0.219490137437016 0.409748112896453 no 2005 0.413134130877341 667 616278 SGTC_2391 6285546 200 µM -0.220021373631179 0.409530653673218 no 2006 0.412927254399033 632 846083 SGTC_2080 5212524 12.4 µM -0.224858601287054 0.407551844045781 no 2007 0.411044637974802 647 260183 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.225056448637853 0.407470958616405 no 2008 0.410967680399569 659 165521 SGTC_336 4111-0029 111 µM -0.225189796153211 0.407416444715918 no 2009 0.41091581354873 661 3131175 SGTC_904 1141-0088 396 µM -0.225315500452828 0.407365057086115 no 2010 0.410866921029256 683 1378119 SGTC_1624 st003710 6.25 µM -0.225407549537135 0.407327428642311 no 2011 0.410831119539071 683 24207033 SGTC_641 4092-0595 30 µM -0.227083965998253 0.406642281790911 no 2012 0.410179225834025 640 786260 SGTC_1891 st059073 26.2 µM -0.22769705653784 0.406391784586047 no 2013 0.409940880440766 645 688754 SGTC_1840 st055363 71 µM -0.227988731510793 0.406272625146408 no 2014 0.409827500402405 662 676033 SGTC_1021 4476-0760 85.3 µM -0.228324246695971 0.406135566181128 no 2015 0.409697088100174 642 746768 SGTC_1102 cgs 12066b 26.1 µM -0.228946668582772 0.405881335435802 no 2016 0.409455183725361 631 6438352 A 5-HT1B full agonist. SGTC_2413 inermin 26.06 µM -0.23212627678554 0.40458323297525 no 2017 0.408219968140058 685 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_845 0330-0138 4.51 µM -0.235123816613171 0.403360422245618 no 2018 0.407056316907061 652 9039800 SGTC_3165 9101544 49.47 µM -0.235480252910806 0.403215080880336 no 2019 0.406918001937355 664 5002184 SGTC_32 0928-0142 34.1 µM -0.237956419775732 0.402205762908525 no 2020 0.405957447684359 655 2244242 SGTC_578 3460-0051 92 µM -0.238709328585897 0.40189899633508 no 2021 0.40566549134058 680 2876744 SGTC_2325 6158266 200 µM -0.239622627764745 0.401526961134984 no 2022 0.405311410671452 636 3623240 SGTC_3043 9092303 49.47 µM -0.239910252767256 0.401409814676808 no 2023 0.405199916195383 657 25236084 SGTC_144 4161-2749 112.381 µM -0.239967297128383 0.401386582196857 no 2024 0.405177804528349 643 797501 YMR168C CEP3 SGTC_3262 9137218 49.47 µM -0.241138114454717 0.400909820071607 no 2025 0.404724036569161 637 17650664 SGTC_406 estrone 100 µM -0.241325479604605 0.400833537809439 no 2026 0.40465143224645 674 5870 A steroid. SGTC_1659 st012954 42.1 µM -0.241424632691081 0.400793170990315 no 2027 0.40461301158047 684 24207262 SGTC_2208 7283366 200 µM -0.242403286463753 0.40039480216265 no 2028 0.404233844037524 645 898663 SGTC_2511 berberine 10.47 µM -0.244865128958023 0.399393148479917 no 2029 0.403280431449802 656 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_942 3253-1115 227 µM -0.245040853579165 0.39932167636235 no 2030 0.403212399421501 680 46497897 SGTC_2519 cryptotanshinone 88.04 µM -0.245480504507001 0.399142872822498 no 2031 0.40304220079859 645 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_497 capsazepine 133 µM -0.24792741437895 0.398148116017047 no 2032 0.402095284179954 637 2733484 A calcium channel blocker. SGTC_1426 4048-4480 71.7 µM -0.250028496293888 0.397294478387531 no 2033 0.401282655748033 671 14224343 SGTC_3226 9131256 49.47 µM -0.250784961862904 0.396987258103819 no 2034 0.400990184402428 640 17178073 SGTC_2062 5245942 200 µM -0.252438795861338 0.396315816098302 no 2035 0.400350958064517 651 1376160 SGTC_2430 5571206 200 µM -0.252510931066352 0.396286536824262 no 2036 0.400323083018134 670 1731771 SGTC_2598 perillyl alcohol 100 µM -0.25379670777143 0.395764745576923 no 2037 0.399826308504293 652 10819 An apoptosis inducer. SGTC_1802 st050112 57.9 µM -0.254168701360278 0.395613818696198 no 2038 0.399682614729091 642 4662563 SGTC_3185 9108267 49.47 µM -0.25467030665773 0.395410329967704 no 2039 0.399488876024945 671 4910486 SGTC_2375 9072683 200 µM -0.255970217233427 0.394883121564705 no 2040 0.398986917279435 675 16798029 SGTC_2829 7992743 58.44 µM -0.255997319727336 0.394872131574115 no 2041 0.398976453461748 667 16462845 SGTC_2074 5212007 75.395 µM -0.256214525544017 0.394784058204098 no 2042 0.398892596567075 643 758611 SGTC_298 1391-0729 10 µM -0.257997106869492 0.394061454449505 no 2043 0.398204570023187 651 3237558 SGTC_817 1391-0715 46 µM -0.258215518420856 0.393972942129543 no 2044 0.398120290986079 678 1353946 SGTC_1644 st010134 20.9 µM -0.259376706337031 0.393502457263448 no 2045 0.397672300262342 680 3818134 SGTC_1244 0416-0015 52.5 µM -0.259837629995876 0.393315745362211 no 2046 0.39749451153009 670 96201 SGTC_1806 st050005 60.3 µM -0.259839630268227 0.393314935141219 no 2047 0.397493740025952 661 5194765 SGTC_3336 9143619 71.43 µM -0.259903184342834 0.393289192464658 no 2048 0.397469227456996 677 45595730 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.260143430763304 0.393191884495235 no 2049 0.397376568969855 648 6708784 An antioxidant flavonoid SGTC_1631 benzylvanillin 81.9 µM -0.260470420886041 0.39305945309919 no 2050 0.397250464387727 661 75506 SGTC_2879 9041815 71.43 µM -0.261516683350436 0.392635798751936 no 2051 0.39684704279848 648 4942971 SGTC_1022 4477-0945 21.3 µM -0.261627917660172 0.392590765039859 no 2052 0.396804159162514 648 4648966 SGTC_2210 7115885 190.385 µM -0.26167396487982 0.392572123036095 no 2053 0.396786407161491 678 2927039 SGTC_619 1652-1634 108 µM -0.262593220639004 0.392200018224132 no 2054 0.396432062943099 660 5400454 SGTC_344 k064-0035 6.43 µM -0.262789159986281 0.39212071682146 no 2055 0.396356545527998 685 5088750 SGTC_1610 st001799 48.1 µM -0.263771491217031 0.391723211167529 no 2056 0.395978001753742 646 621897 SGTC_398 bronopol 33.3 µM -0.263964194469891 0.391645245999079 no 2057 0.395903754573396 667 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_333 3486-0131 40.1 µM -0.264091570367907 0.39159371379676 no 2058 0.395854679627067 647 6744690 SGTC_1925 st057770 10.1 µM -0.265421575536965 0.391055750160775 no 2059 0.395342358574399 667 5989122 SGTC_2857 9024691 58.44 µM -0.265433812331167 0.391050801559215 no 2060 0.395337645771306 718 16478292 SGTC_1711 st032263 62.8 µM -0.265516667414397 0.391017295143383 no 2061 0.395305735880713 666 3958979 SGTC_2409 alverine citrate 63.97 µM -0.26735891550167 0.390272503399882 no 2062 0.394596414523194 646 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2658 polymyxin b sulfate 77.05 µM -0.267990980068611 0.390017062308671 no 2063 0.394353130868871 657 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1684 st024538 14.6195 µM -0.268105083010054 0.389970954070435 no 2064 0.394309216673326 648 6732859 SGTC_1738 st035555 74 µM -0.268202367997203 0.389931643078082 no 2065 0.394271776175843 708 5331140 SGTC_1808 st050063 61.5 µM -0.268614469107585 0.389765133433949 no 2066 0.39411318833298 701 4011993 SGTC_2929 9013348 24.6 µM -0.268792560787575 0.389693181666766 no 2067 0.394044659186562 666 2995952 SGTC_2047 4141938 200 µM -0.269298161047185 0.38948893202427 no 2068 0.393850123600107 658 3807862 SGTC_2013 4024628 200 µM -0.269546402411521 0.38938865999691 no 2069 0.393754619536482 691 5230760 SGTC_548 1436-0017 110 µM -0.269577759570392 0.389375994436967 no 2070 0.393742556183193 680 9677137 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.272443634603242 0.388218928427329 no 2071 0.392640462768053 648 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2455 5377712 9.75 µM -0.272821465341842 0.388066457109893 no 2072 0.392495229162112 642 2243908 SGTC_119 0121-0043 24.815 µM -0.273484181910032 0.387799063515329 no 2073 0.39224052502698 685 1092378 SGTC_873 0591-4978 488 µM -0.273621444723364 0.38774368721382 no 2074 0.392187776105363 692 3305145 SGTC_1035 k081-0041 55.2 µM -0.273809666811326 0.387667755988932 no 2075 0.392115447192735 673 731709 SGTC_778 3456-2434 196 µM -0.273937431409843 0.387616216544834 no 2076 0.392066352663762 672 5539063 SGTC_309 k408-0051 1.48 µM -0.276142805456673 0.386726895206516 no 2077 0.391219192175354 670 3640463 SGTC_708 3448-5400 146 µM -0.276544835331632 0.38656483981145 no 2078 0.391064814056741 662 3462195 SGTC_3096 9117468 49.47 µM -0.277802586887054 0.386057976930738 no 2079 0.390581952635993 712 41316311 SGTC_3061 glucosamine 200 µM -0.27863311736341 0.38572338693372 no 2080 0.3902631974142 655 91431 and experimental redox chemotherapeutic SGTC_2502 avocadyne acetate 18.59 µM -0.278748230272243 0.385677018904415 no 2081 0.390219023224146 646 3952079 SGTC_55 0767-0285 6.563 µM -0.279124535829094 0.385525452631655 no 2082 0.390074627130609 678 3116166 SGTC_217 ketoconazole 989 nM -0.281061116218524 0.384745724402829 no 2083 0.389331762126411 658 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1960 st011366 51.8 µM -0.281801735737064 0.38444765066747 no 2084 0.389047769962716 649 3972846 SGTC_3218 9131285 49.47 µM -0.281953889044587 0.384386422677326 no 2085 0.388989433780035 706 17156417 SGTC_2296 7971656 126.45 µM -0.282237997554698 0.384272102335946 no 2086 0.388880512148584 660 666570 SGTC_2365 9042475 200 µM -0.28224236626477 0.384270344521275 no 2087 0.388878837338972 666 6464479 SGTC_2552 juarezic acid 87.02 µM -0.282433403911396 0.384193480046089 no 2088 0.388805602252018 660 1549512 SGTC_396 dithiazanine 1.25 µM -0.282929315547645 0.383993970020821 no 2089 0.388615510884181 659 10578 An antihelmenthic. SGTC_2170 morpholine 200 µM -0.286624490492375 0.382508336777306 no 2090 0.387199930091069 677 121171 Reacts with secondary amines. SGTC_1196 1588-0294 184 µM -0.288616090621788 0.381708335335607 no 2091 0.386437590374066 693 6144269 SGTC_58 0957-0393 9 µM -0.288948009826321 0.381575056447867 no 2092 0.386310581684515 681 6997992 SGTC_2394 5221648 200 µM -0.289702535579603 0.381272136318155 no 2093 0.386021908182432 682 788586 SGTC_165 k038-0023 64.381 µM -0.290232424168154 0.381059444931518 no 2094 0.385819216167216 674 46368543 SGTC_1261 0712-0010 12.7 µM -0.291367102435109 0.38060411860758 no 2095 0.385385286010896 692 2840123 SGTC_2966 9084041 48.03 µM -0.291481424808441 0.380558252218891 no 2096 0.385341574140044 674 17741380 SGTC_3205 9113483 49.47 µM -0.292976086890842 0.379958745178572 no 2097 0.384770214995153 709 17018033 SGTC_332 4112-0506 40.9 µM -0.295196154074566 0.379068811671814 no 2098 0.38392201988385 670 2790355 SGTC_250 brefeldin a 552.239 µM -0.295403318809938 0.37898580046651 no 2099 0.383842899163024 663 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2014 4013930 200 µM -0.296343742258712 0.378609041671527 no 2100 0.383483791905485 712 64556 SGTC_1502 4534-4282 27.7 µM -0.296429550475676 0.378574670341193 no 2101 0.383451030416307 705 3278949 SGTC_1306 1185-0270 9.02 µM -0.29670531107176 0.378464218210672 no 2102 0.383345750946954 676 1548076 SGTC_3281 9140613 49.47 µM -0.299276531383994 0.377434830125335 no 2103 0.382364529847301 659 16013766 SGTC_8 0354-0001 70 µM -0.299459638622097 0.377361556243843 no 2104 0.382294681751635 680 4993152 SGTC_2757 clomiphene 4.22 µM -0.299563637457667 0.377319941076018 no 2105 0.382255012056148 678 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2201 6605497 169.863 µM -0.300381132793037 0.376992869697674 no 2106 0.381943226721098 707 670741 SGTC_3275 9138069 49.47 µM -0.300728156693129 0.376854055712236 no 2107 0.38181089807534 676 17617007 SGTC_2585 alliin 100 µM -0.301141513341402 0.376688728555038 no 2108 0.381653293162731 713 87310 A garlic compound which reacts with lipids. SGTC_1734 st037168 69.4 µM -0.30316787605567 0.37587858712696 no 2109 0.380880964429147 691 708907 SGTC_737 1950-0117 57.9 µM -0.305282537665762 0.375033726772313 no 2110 0.380075487232284 682 5393513 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.305487035811672 0.374952056347654 no 2111 0.379997621151333 688 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_25 0118-0223 35.662 µM -0.305784416393593 0.374833301470658 no 2112 0.379884397213993 679 5333628 SGTC_3292 9120825 59.784 µM -0.30607705970144 0.374716449944697 no 2113 0.379772986985235 686 24824900 SGTC_522 1273-0010 11.6 µM -0.308305224655187 0.373827128801748 no 2114 0.3789250454276 650 5705015 SGTC_923 1900-2434 73.3 µM -0.308436735419489 0.373774660218249 no 2115 0.378875016377358 708 5910570 SGTC_2113 5491891 107.031 µM -0.308664265098365 0.373683888687551 no 2116 0.378788464805241 703 789979 SGTC_1756 st041558 35.5 µM -0.308817439990113 0.373622784476097 no 2117 0.37873020098272 720 3955792 SGTC_2827 7993847 71.43 µM -0.308896545556485 0.373591229090799 no 2118 0.378700112321739 693 2985692 SGTC_3011 9081274 71.4286 µM -0.312975187704768 0.371965402500829 no 2119 0.377149756587868 671 6625322 SGTC_2316 5844804 197.44 µM -0.313194469372469 0.371878056875016 no 2120 0.377066460009912 705 776813 SGTC_3015 9080845 49.47 µM -0.314245063187413 0.371459669416084 no 2121 0.376667459697135 715 5296973 SGTC_2234 tolnaftate 200 µM -0.314462356844568 0.371373153533248 no 2122 0.376584951138003 694 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_128 0906-2981 13.371 µM -0.315586739941941 0.370925582165525 no 2123 0.376158101851188 714 6740226 SGTC_3069 9117009 49.47 µM -0.318340067795727 0.369830332081644 no 2124 0.375113497093381 664 41904981 SGTC_2707 st078556 66.6 µM -0.320443933654211 0.368994142944812 no 2125 0.374315912826825 673 17250899 SGTC_767 0929-0023 86 µM -0.32114657014741 0.368715015350193 no 2126 0.374049660001045 666 1204563 SGTC_178 4092-0806 87.505 µM -0.32129792799656 0.368654896374032 no 2127 0.373992313232583 661 2169044 SGTC_46 0329-0187a 2.197 µM -0.321976116494881 0.368385561010814 no 2128 0.373735394059709 707 46494817 SGTC_2142 5622915 118.518 µM -0.322445379887616 0.368199235875752 no 2129 0.373557655129181 665 5322196 SGTC_532 1548-0774 215 µM -0.322469432108374 0.368189686565842 no 2130 0.373548545796941 738 5932993 SGTC_690 glyoxal 20.3 µM -0.322854489034768 0.368036820799939 no 2131 0.373402722254842 692 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.324969638261371 0.367197489841371 no 2132 0.37260202538743 706 1377 SGTC_285 1486-1325 46 µM -0.32510619436672 0.367143323565458 no 2133 0.372550350485851 672 22310230 SGTC_1800 st050079 29.0735 µM -0.325361150688391 0.367042199797243 no 2134 0.372453877287119 688 3645560 SGTC_1809 st050081 57.6 µM -0.325629029312143 0.366935960570878 no 2135 0.372352523025678 698 5036894 SGTC_2186 6124449 200 µM -0.326113671970457 0.366743779789689 no 2136 0.372169176632625 684 3834182 YLR033W RSC58 SGTC_959 1222-0044 107 µM -0.327728274431647 0.366103764613907 no 2137 0.371558561563187 701 6083612 SGTC_1614 st002383 48.6 µM -0.328976690292213 0.365609157950999 no 2138 0.371086653376209 694 1947235 SGTC_3164 9100705 49.47 µM -0.329108480196507 0.365556957468376 no 2139 0.371036847350486 704 17174235 SGTC_1912 st060209 90.8 µM -0.330447339975703 0.365026791616628 no 2140 0.370530988193379 729 688787 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.330513826270869 0.365000470880789 no 2141 0.370505873612288 684 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1469 k284-2957 126 µM -0.331011489564804 0.364803475086055 no 2142 0.370317903453303 687 23884841 SGTC_416 estradiol valerate 100 µM -0.33273379237724 0.364121991883766 no 2143 0.369667619479218 704 13791 A steroid. SGTC_870 0573-2213 57.6 µM -0.33297119451633 0.364028089899249 no 2144 0.369578013543366 677 3916321 SGTC_797 k781-0471 270 µM -0.333996427471544 0.363622663321576 no 2145 0.369191127247432 665 23738129 SGTC_2162 5663267 200 µM -0.33442794180568 0.363452067359297 no 2146 0.369028328738113 731 6456493 SGTC_1151 3909-8316 15.3 µM -0.334796319688437 0.363306453342383 no 2147 0.368889368464715 722 800431 SGTC_2779 methotrexate 400 µM -0.334868696107271 0.363277846396652 no 2148 0.368862068494749 693 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_849 0386-0493 241 µM -0.33527637788441 0.363116723487859 no 2149 0.368708305630944 692 726119 SGTC_2256 7954252 200 µM -0.339379602149729 0.36149641118798 no 2150 0.367161891434005 717 2972920 SGTC_2313 7726885 200 µM -0.340238500735457 0.361157555831699 no 2151 0.366838463215831 688 726423 SGTC_2531 methyl deoxycholate 70.07 µM -0.34156526565328 0.36063433053614 no 2152 0.366339040321475 725 16667744 Haematoxylin. SGTC_2646 retinol 96.75 µM -0.341838540470292 0.360526593767756 no 2153 0.366236201871166 711 445354 A vitamin A analog and teratogen. SGTC_451 chloral hydrate 100 µM -0.3430808443414 0.360036963454754 no 2154 0.365768820771148 721 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_709 3807-1509 243 µM -0.343083539077499 0.360035901625266 no 2155 0.36576780717044 725 1886677 YPL242C IQG1 SGTC_1499 4480-0877 67.3 µM -0.343706321025453 0.359790530607677 no 2156 0.365533578498712 685 2861909 SGTC_166 k072-0058 166.424 µM -0.343811444581891 0.359749118478905 no 2157 0.365494046407889 718 5846229 SGTC_2847 9005661 71.43 µM -0.343926854476113 0.359703656070371 no 2158 0.365450647748143 665 2991449 SGTC_351 caspofungin 25 nM -0.345066028007852 0.359255018019603 no 2159 0.365022366189567 670 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3028 9087778 49.47 µM -0.345305341663843 0.359160794318217 no 2160 0.364932415651171 666 17217395 SGTC_2571 chrysanthemic acid 100 µM -0.346297463346648 0.358770262913951 no 2161 0.364559587389336 750 2743 An insecticide. SGTC_445 e6 berbamine 66 µM -0.347149318317471 0.358435062807878 no 2162 0.364239571971421 712 6610268 A calcium/calmodulin antagonist. SGTC_2425 5628681 7.85 µM -0.347236016605146 0.358400953632507 no 2163 0.364207007422966 707 5714958 SGTC_3008 9078912 71.4286 µM -0.347695770747717 0.358220094267243 no 2164 0.364034336593988 730 16648731 SGTC_464 bw-b 70c 158 µM -0.347710291290394 0.358214382653662 no 2165 0.364028883532723 736 5353454 SGTC_2528 xanthyletin 44.79 µM -0.348635227177744 0.357850627218814 no 2166 0.363681588823895 692 65188 An natural product with antifungal activity of unknown mechanism. SGTC_343 4130-2827 29.8 µM -0.348643924422924 0.357847207409642 no 2167 0.36367832371531 680 1118244 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.351378608049562 0.35677248042694 no 2168 0.362652164409533 714 4174840 SGTC_2444 5485484 36.41 µM -0.351832717952922 0.356594125594542 no 2169 0.362481860007715 735 6790631 SGTC_1678 st019265 80.2 µM -0.352184257838889 0.356456077380015 no 2170 0.362350041023082 730 5367020 SGTC_2812 7970281 58.44 µM -0.353514822835349 0.355933740605084 no 2171 0.361851259114366 724 2233435 SGTC_2786 7743617 45.45 µM -0.355069738406112 0.355323673606387 no 2172 0.361268673357637 709 583674 SGTC_1078 idebenone 36.1 µM -0.355357584769334 0.355210778452951 no 2173 0.36116086017188 686 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1489 4065-0444 182 µM -0.35546164322093 0.355169969200652 no 2174 0.361121887672809 686 2877968 SGTC_163 TUB2.036 7.546 µM -0.355931077284325 0.354985888969946 no 2175 0.3609460907718 691 15992207 YJR013W GPI14 SGTC_2991 9074669 71.4286 µM -0.35654590731074 0.354744845490891 no 2176 0.360715889419405 735 17333109 SGTC_3186 9110464 49.47 µM -0.357498436314377 0.354371522320746 no 2177 0.360359348300134 705 17018021 SGTC_1470 k295-0292 231 µM -0.357831010006921 0.354241210172595 no 2178 0.360234891221949 689 5045612 SGTC_534 k292-0788 63.4 µM -0.357909791780788 0.354210343657468 no 2179 0.360205411355748 717 4146317 SGTC_918 glabranin 770.725 nM -0.360994124506775 0.353002663889427 no 2180 0.359051919654485 712 124049 Also referred to as licorice root. SGTC_2429 5902844 64.44 µM -0.361081436002688 0.352968498284944 no 2181 0.359019285172331 717 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3251 9135047 49.47 µM -0.362517851502669 0.352406589119503 no 2182 0.358482542945834 702 17682963 SGTC_2055 5235184 200 µM -0.362754446787564 0.352314066626692 no 2183 0.358394161682036 758 2836034 SGTC_3004 9076122 71.4286 µM -0.362933293276993 0.352244133065461 no 2184 0.358327357781803 729 44782551 SGTC_2291 7917025 104.35 µM -0.363113189657063 0.352173794010052 no 2185 0.358260166093927 695 2964612 SGTC_345 1362-0200 395 µM -0.363989144062523 0.351831370226162 no 2186 0.357933057975183 713 1419823 SGTC_2804 7954240 19.48 µM -0.364534991455955 0.351618050994829 no 2187 0.357729274615649 696 828705 SGTC_1889 st059080 5.18 µM -0.365219795114058 0.351350493200603 no 2188 0.357473671513168 710 176925 Isolated from Daphnopsis sellowiana. SGTC_1154 4088-0362 150 µM -0.366417180095429 0.350882843166177 no 2189 0.357026900982842 712 6618304 SGTC_371 0195-0006 7.36 µM -0.366504132052159 0.350848892042425 no 2190 0.356994464931339 678 3928593 SGTC_970 1315-0089 19.5 µM -0.369125225131736 0.349826024297951 no 2191 0.356017193811376 690 6811083 YLR033W RSC58 SGTC_1603 st002045 67.8 µM -0.370418186080391 0.349321853706508 no 2192 0.355535462734901 716 5887985 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.371401388259672 0.348938646690705 no 2193 0.355169295860047 745 6710655 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.372380934711595 0.348557017659911 no 2194 0.354804623402277 742 5393153 SGTC_228 caffeine 993.056 µM -0.373421796494055 0.348151668222246 no 2195 0.354417269791149 707 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1104 tacrolimus 29.8 µM -0.375484211818421 0.347349001278527 no 2196 0.35365019304942 701 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_47 0149-0135 24.25 µM -0.375964268274864 0.347162267167856 no 2197 0.353471730134365 706 5239155 SGTC_794 k038-0031 316 µM -0.37644154854892 0.346976649725369 no 2198 0.353294331204156 698 6624242 SGTC_256 clotrimazole 625 nM -0.377755616239114 0.346465789946002 no 2199 0.352806073940297 689 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1329 1447-1697 50.6 µM -0.378312257247656 0.346249473101643 no 2200 0.352599320463476 706 2840515 SGTC_541 4513-1321 94 µM -0.378393753757423 0.346217806864628 no 2201 0.352569053822064 691 747515 SGTC_3302 9125395 16.351 µM -0.378930610483803 0.346009233000509 no 2202 0.352369696223944 704 17599668 SGTC_2285 7945142 200 µM -0.378978672929518 0.34599056256762 no 2203 0.352351850582988 749 2970608 SGTC_2063 5246145 200 µM -0.379504375922327 0.345786371394803 no 2204 0.352156677691098 743 711240 SGTC_717 1532-0246 73.2 µM -0.379521368063905 0.345779772132145 no 2205 0.352150369825048 720 9561992 SGTC_626 0214-0009 33 µM -0.379606739653152 0.345746616953379 no 2206 0.35211867858201 725 3437874 SGTC_1123 mangostin 811.285 nM -0.381138146562485 0.3451520761058 no 2207 0.351550371490934 695 5281650 An antioxidant. SGTC_2400 5203494 178.7 µM -0.381257819764215 0.3451056312379 no 2208 0.351505974565326 707 6777674 SGTC_2780 5215298 71.43 µM -0.381519786129633 0.345003970896355 no 2209 0.351408796125527 737 2834131 SGTC_1775 st081588 35.1725 µM -0.386681911550537 0.343003013840918 no 2210 0.349495854477348 731 1426443 YGL099W LSG1 SGTC_1028 k015-0029 4.8 µM -0.387459829895682 0.342701854720132 no 2211 0.349207909019503 709 4588309 SGTC_2842 9000675 19.48 µM -0.387895968927934 0.342533053914188 no 2212 0.349046510681719 680 2989072 SGTC_3246 9135460 32.98 µM -0.388619844828253 0.342252958461159 no 2213 0.348778692234173 721 41446951 SGTC_3249 9135183 49.47 µM -0.389235295508286 0.342014885130038 no 2214 0.348551048021715 728 4902779 SGTC_783 0848-0141 92.7 µM -0.389710596021097 0.341831068725973 no 2215 0.348375280164095 700 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_589 1227-0070 34.1 µM -0.390537474902568 0.341511373243976 no 2216 0.348069574948434 693 2841384 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.390598474394031 0.341487793561763 no 2217 0.348047026746572 731 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1225 1216-0074 20.6 µM -0.392164483713398 0.340882656267068 no 2218 0.347468342216052 712 4241466 SGTC_2343 7990716 14.84 µM -0.392624301721489 0.340705051040333 no 2219 0.347298493938045 710 6456862 SGTC_1455 4262-0120 131 µM -0.393273765533503 0.340454255068911 no 2220 0.347058646247706 703 1529587 SGTC_677 0929-0063 136 µM -0.39437343539973 0.340029769079101 no 2221 0.346652676679267 721 1539583 SGTC_2034 5197015 53.07 µM -0.396538801069992 0.339194504465423 no 2222 0.34585379483266 754 780676 SGTC_642 0335-0876 158 µM -0.396564517147427 0.339184589524484 no 2223 0.345844311353632 714 6812350 SGTC_2939 9044578 71.43 µM -0.397152109376113 0.338958071243432 no 2224 0.345627647646883 702 2653634 SGTC_863 0466-0191 129 µM -0.399121084385888 0.338199451188446 no 2225 0.34490199362838 735 765160 YPR165W RHO1 SGTC_460 trequinsin 123 µM -0.399237540278637 0.33815460280286 no 2226 0.344859092333767 713 5537 A vasodilator. SGTC_2971 9092186 9.93 µM -0.400303124174281 0.337744341984999 no 2227 0.344466633576566 676 25236400 SGTC_1309 pyrazolanthrone 13.4 µM -0.401902413148065 0.337128960975175 no 2228 0.343877923354354 712 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2339 9000433 200 µM -0.402122684048784 0.337044238319511 no 2229 0.343796869599378 689 2988954 SGTC_2667 digitoxin 100 µM -0.402923293816077 0.336736369941179 no 2230 0.3435023272739 701 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3044 9093193 49.47 µM -0.403257069378466 0.336608051388024 no 2231 0.34337956013101 749 25236277 SGTC_1380 2291-0730 164 µM -0.405143394345031 0.335883219931791 no 2232 0.34268605531652 725 2999191 SGTC_1311 1190-0148 100 µM -0.406211088098165 0.33547322249373 no 2233 0.342293753828808 723 1961333 SGTC_3086 9117350 49.47 µM -0.406524768945799 0.335352805354798 no 2234 0.342178530748636 723 2679265 SGTC_188 3229-0966 278.469 µM -0.406876660660825 0.335217739795427 no 2235 0.342049289315831 728 5722370 SGTC_1854 st056233 32.9 µM -0.407047205361463 0.335152287788103 no 2236 0.341986658971492 759 5393174 SGTC_1423 4048-0112 5.59 µM -0.407807382975838 0.334860606106148 no 2237 0.341707546435362 719 X1423 SGTC_2140 5586273 200 µM -0.407830329994621 0.334851802836552 no 2238 0.341699122379683 721 854421 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.408055236213743 0.334765525841051 no 2239 0.341616561470066 736 5711223 A potent inhibitor of glutathione S-transferases. SGTC_758 0868-0029 16 µM -0.409279914677672 0.334295876165305 no 2240 0.34116712683281 691 762687 SGTC_2435 5706476 10.6 µM -0.409684391488842 0.334140821021682 no 2241 0.34101874067473 703 5725375 SGTC_1671 st016596 74.5 µM -0.410016577593344 0.334013499499606 no 2242 0.340896893435741 705 2829167 SGTC_310 1273-0058 1.06 µM -0.41008618953413 0.333986820797257 no 2243 0.340871361590303 719 2734232 SGTC_1362 1611-0397 101 µM -0.410346309818005 0.33388713740052 no 2244 0.340775962701271 715 27816 SGTC_1036 k216-0215 33.5 µM -0.411339691890699 0.333506561036069 no 2245 0.340411734425234 717 622330 SGTC_3132 9126706 49.47 µM -0.411392290958111 0.333486414485846 no 2246 0.340392452871631 776 850858 SGTC_1973 st070275 50.2 µM -0.412503887773295 0.333060761900577 no 2247 0.339985065851644 729 17118334 SGTC_1789 tunicamycin 25 nM -0.413644313633896 0.332624293502094 no 2248 0.339567307420695 744 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.413928266083165 0.332515653313133 no 2249 0.339463321167544 714 5106787 A p450 inhibitor. SGTC_2543 pimpinellin 60.67 µM -0.414237957907522 0.332397181278173 no 2250 0.339349922829022 717 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1746 st038117 42 µM -0.415195363636814 0.332031033417314 no 2251 0.338999446299295 726 2898218 SGTC_1438 4092-1045 4 µM -0.41550385542327 0.331913088723136 no 2252 0.338886546687427 718 1351342 SGTC_14 0354-0009 295 µM -0.417049707372182 0.3313223190408 no 2253 0.338321024988687 736 1713507 SGTC_3236 9132701 49.47 µM -0.417125777197505 0.331293258674999 no 2254 0.338293205632422 738 24282524 SGTC_2814 7977482 42.97 µM -0.418840165536595 0.330638593916874 no 2255 0.337666474190901 737 6456762 SGTC_2773 thioridazine 9.09 µM -0.420078660938228 0.330165977973171 no 2256 0.337213995418362 730 5452 An antipsychotic. SGTC_1457 k015-0032 57.3 µM -0.420120653786384 0.330149958039103 no 2257 0.337198657640484 752 4302660 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.420581311435021 0.329974241298179 no 2258 0.337030421410152 712 676296 Flavone; oxidizing agent. SGTC_2915 7971052 15.16 µM -0.420793933350259 0.32989314983384 no 2259 0.336952781005511 736 5741558 SGTC_486 niguldipine 82 µM -0.42252465156918 0.32923337217018 no 2260 0.336321055583118 708 1236 A calcium channel blocker. SGTC_1168 k815-0004 80.5 µM -0.422711147522326 0.329162308593136 no 2261 0.336253010664093 709 642433 SGTC_1169 aniline yellow 25.8 µM -0.42308899332402 0.329018350803991 no 2262 0.336115166278606 732 6051 A DNA damaging agent. SGTC_996 3970-0799 1.8 µM -0.424626029772878 0.32843300740903 no 2263 0.335554657307156 704 6615648 YGL040C HEM2 SGTC_194 1486-1323 56.904 µM -0.425113846126804 0.328247322183317 no 2264 0.335376842386513 725 5178754 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.425419516142445 0.328130991806922 no 2265 0.335265440782241 761 229346 A bile salt which induces apoptosis. SGTC_2236 dapsone 200 µM -0.426103294187935 0.32787082331378 no 2266 0.335016289957773 726 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2184 6075246 200 µM -0.426705796126012 0.327641648513097 no 2267 0.334796814170377 721 2267320 SGTC_2214 7179297 48.276 µM -0.427300015493656 0.327415687750405 no 2268 0.334580410767678 702 769744 SGTC_2710 st078562 53.7235 µM -0.42773654782378 0.327249730103857 no 2269 0.33442146898969 755 17250908 SGTC_121 0557-0495 61.343 µM -0.427764588378837 0.327239071018843 no 2270 0.334411260414728 735 3104427 SGTC_2408 sulbentine 18.36 µM -0.428259506841996 0.327050960349283 no 2271 0.334231098255467 739 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2330 7979373 200 µM -0.429069959782952 0.326743014909448 no 2272 0.333936156471197 719 1863007 SGTC_2178 5812956 200 µM -0.429217558525836 0.326686944940097 no 2273 0.333882453051654 720 5403383 SGTC_441 propafenone 146 µM -0.430793932085367 0.326088354808203 no 2274 0.333309106013625 706 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1153 4055-0057 267 µM -0.430918188082264 0.326041190589144 no 2275 0.333263929067168 730 882706 SGTC_1459 k035-0031 35.7 µM -0.43139515871468 0.32586017127377 no 2276 0.333090534741078 715 3877128 YMR208W ERG12 SGTC_405 ebelactone b 50 µM -0.431629059611373 0.32577141648498 no 2277 0.333005517198198 730 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2694 st077685 81.9 µM -0.431704935218528 0.325742627251922 no 2278 0.332977940020941 697 2838096 SGTC_1336 1486-0901 104 µM -0.43254328781325 0.325424603078897 no 2279 0.332673298852062 710 5006114 SGTC_3090 9117696 49.47 µM -0.433645635844249 0.325006627184492 no 2280 0.332272894956455 743 7923821 SGTC_2584 androsterone 48.74 µM -0.435915855447048 0.324146524909173 no 2281 0.3314488904562 736 2754130 A steroid. SGTC_236 1509-0011 5.31 µM -0.436501630902866 0.323924748253549 no 2282 0.331236408099769 771 3107280 SGTC_1729 st035615 45.989 µM -0.437009460166632 0.323732532865994 no 2283 0.331052243660358 723 17385451 SGTC_2561 acetosyringone 100 µM -0.437019457680133 0.323728749239207 no 2284 0.331048618469054 760 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.437422247166113 0.323576325983317 no 2285 0.330902576435314 776 688798 SGTC_1246 0422-0085 105 µM -0.440059491125814 0.322579074565265 no 2286 0.329947010130719 762 264295 SGTC_2126 5251174 33.877 µM -0.440092605127662 0.322566560877341 no 2287 0.32993501879684 739 790722 SGTC_318 1488-0629 67.2 µM -0.440237913081977 0.322511651787347 no 2288 0.329882401544796 752 3662576 SGTC_1719 st032227 49.2 µM -0.440701486200047 0.322336502273961 no 2289 0.329714560258905 710 3125804 SGTC_968 1309-0633 340 µM -0.440894740671655 0.322263497547234 no 2290 0.329644600667948 762 3761976 SGTC_3207 9114163 49.47 µM -0.44114772511647 0.322167939303692 no 2291 0.329553027380756 788 849233 SGTC_1160 4092-0570 10.5 µM -0.44218008520566 0.321778114234514 no 2292 0.329179447916629 749 4994975 SGTC_2512 diallyl trisulfide 49.23 µM -0.442313692027638 0.321727677857778 no 2293 0.329131112157882 752 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1546 5-methoxyflavanone 78.7 µM -0.443089729603802 0.321434789804448 no 2294 0.328850416788615 722 147795 SGTC_612 0302-0167 22.4 µM -0.44502426781246 0.320705149976297 no 2295 0.328151108310968 740 235821 SGTC_131 0141-0277 33.849 µM -0.445034539324847 0.320701277767637 no 2296 0.32814739690728 760 1547771 SGTC_257 daunorubicin 18.5 µM -0.445776378102891 0.320421667100204 no 2297 0.327879393317163 742 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_581 0958-0271 211 µM -0.447000916758245 0.319960342269174 no 2298 0.327437198986026 737 4591145 SGTC_980 1473-0395 201 µM -0.449027778166938 0.319197367240141 no 2299 0.326705809102689 747 768876 SGTC_510 ag-490 170 µM -0.449131544613528 0.319158326815515 no 2300 0.32666838301986 746 5328779 SGTC_3240 9133527 49.47 µM -0.450798004974134 0.318531623398518 no 2301 0.326067569660182 774 17617455 SGTC_657 3534-0529 86.7 µM -0.452069658318287 0.318053743384405 no 2302 0.325609400555783 746 1049549 SGTC_2802 7925815 54.55 µM -0.452842336872616 0.317763523042561 no 2303 0.325331137655166 735 1262923 SGTC_1016 4226-1401 38 µM -0.453614623928182 0.317473561582151 no 2304 0.325053113017664 744 2901613 SGTC_1958 st076513 41.9 µM -0.454557431590409 0.317119728548665 no 2305 0.32471383269533 752 732122 YGL099W LSG1 SGTC_1692 fluoroquinolonic acid 71 µM -0.454971444121053 0.316964403614489 no 2306 0.324564891382493 761 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3060 1327-0027 12.5 µM -0.455047949259317 0.316935704738498 no 2307 0.324537371672912 750 16000455 YPR107C YTH1 SGTC_1726 st035556 14.5795 µM -0.455423840031883 0.316794715274487 no 2308 0.32440217369531 737 5919439 SGTC_2357 9067248 200 µM -0.456202690895708 0.316502667851646 no 2309 0.324122115292702 754 9150235 SGTC_1627 st003713 25.6 µM -0.456226815712113 0.316493623541517 no 2310 0.324113442103615 715 16195070 YER133W GLC7 SGTC_855 0428-0020 25 µM -0.456312918971325 0.316461344622587 no 2311 0.324082487626807 720 6812414 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.456410105729571 0.316424912333021 no 2312 0.324047550047473 748 77254 SGTC_3170 9103054 49.47 µM -0.456536187073804 0.316377651017534 no 2313 0.324002227489031 764 16432970 SGTC_2907 7721985 69.9 µM -0.459612289128712 0.315225511567237 no 2314 0.322897268323138 741 3267881 SGTC_2344 7990960 76.95 µM -0.460954540441934 0.31472333945755 no 2315 0.322415610204792 756 140813 SGTC_57 miconazole 162.5 nM -0.46195097611844 0.31435076763437 no 2316 0.322058238404112 750 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1611 st001856 99.4 µM -0.461974197227594 0.314342087408832 no 2317 0.322049912109828 772 647478 SGTC_39 0986-0283 58.349 µM -0.462134857544544 0.314282034184436 no 2318 0.321992307270726 720 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_716 1683-5115 658 µM -0.462531114070885 0.314133938461751 no 2319 0.321850247574945 772 723597 SGTC_2173 5763948 167 µM -0.462825147280104 0.31402406671195 no 2320 0.321744852210436 733 2867177 SGTC_1992 st073643 23.3 µM -0.462845428737576 0.314016488722462 no 2321 0.321737582908563 758 3161292 SGTC_1997 st073024 93.8 µM -0.465043375471601 0.313195710463718 no 2322 0.320950197375305 743 686268 SGTC_1629 st005085 44.9 µM -0.465079151266289 0.313182358361633 no 2323 0.320937387812116 758 24207091 SGTC_3075 9116269 49.47 µM -0.465510450922323 0.313021409671465 no 2324 0.320782977265725 770 17015205 YNL244C SUI1 SGTC_707 0865-0008 204 µM -0.466134409925882 0.31278862907877 no 2325 0.320559647186598 760 723043 SGTC_2682 pyrogallin 40.03 µM -0.466321431630161 0.312718871363604 no 2326 0.320492720224664 743 822798 An ATP competetive kinase inhibitor. SGTC_2301 7769476 200 µM -0.467387575516535 0.31232133572565 no 2327 0.320111305065128 741 977820 SGTC_2661 dactinomycin 12.96 µM -0.467503881683877 0.312277981567151 no 2328 0.320069707784339 733 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_926 2268-1401 59.4 µM -0.467566050442831 0.312254808675087 no 2329 0.320047473852118 761 2931578 SGTC_227 fluconazole 33.516 µM -0.467624321127458 0.312233089432335 no 2330 0.320026634607529 752 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_261 5-fluorouridine 15.376 µM -0.468059232901491 0.312071005302115 no 2331 0.319871115797568 741 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_693 4161-2696 114 µM -0.468795249903751 0.311796787317792 no 2332 0.319607997790323 749 805759 SGTC_2028 5153890 36.43 µM -0.468909748257711 0.311754138017556 no 2333 0.31956707404027 763 2830968 YPR165W RHO1 SGTC_2685 mycophenolic acid 18.85 µM -0.469199771949872 0.311646118875329 no 2334 0.319463424241564 739 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2224 6650123 117.647 µM -0.470884669640384 0.311018900577199 no 2335 0.318861548115713 743 2908370 SGTC_1158 4092-0494 91.8 µM -0.470915516174404 0.311007422785586 no 2336 0.318850533617629 758 1148199 SGTC_2355 9061122 103.12 µM -0.471898234361939 0.310641856105155 no 2337 0.318499714201402 754 5302957 SGTC_2988 9073640 71.4286 µM -0.473504425645905 0.310044762741612 no 2338 0.317926672149591 768 9102229 SGTC_2404 5161160 200 µM -0.474737243491098 0.309586808479779 no 2339 0.317487134273198 756 2831543 SGTC_2220 6782180 200 µM -0.475005383300192 0.309487241809366 no 2340 0.317391568130396 742 833803 SGTC_1180 1193-0155 285 µM -0.475620047419036 0.309259055217432 no 2341 0.317172545220376 778 2921347 SGTC_543 3844-1095 191 µM -0.475786065064977 0.309197435793748 no 2342 0.31711339922705 761 4230703 SGTC_355 1311-2252 105 µM -0.477957423523156 0.308392004919821 no 2343 0.316340254504472 764 5338538 SGTC_312 4092-0653 6.84 µM -0.477987273147136 0.308380939088405 no 2344 0.316329631680123 765 1148278 SGTC_3105 9121040 49.47 µM -0.478884798368741 0.308048290530055 no 2345 0.316010293028731 736 41448907 SGTC_2002 4023503 131 µM -0.47910314361174 0.307967389356781 no 2346 0.315932626736277 793 4736863 YCR052W RSC6 SGTC_85 0868-0259 160.055 µM -0.480140961866107 0.307582985085618 no 2347 0.315563581683155 749 83173 SGTC_1013 4112-3890 241 µM -0.480387685560771 0.30749163054248 no 2348 0.315475874515971 748 705171 SGTC_857 0438-0306 1.35 µM -0.481565323453153 0.307055750367778 no 2349 0.315057382359175 737 4686136 SGTC_1193 1488-0126 41.5 µM -0.481637194562377 0.307029157467194 no 2350 0.315031849506953 722 1384710 SGTC_2048 5246248 200 µM -0.482036199499462 0.306881540828052 no 2351 0.314890115522628 739 677046 SGTC_1793 st048256 72.231 µM -0.482666687933078 0.306648347931201 no 2352 0.314666209861624 767 672022 SGTC_2891 9063876 19.48 µM -0.483004913641234 0.306523283772492 no 2353 0.314546123675089 764 6472478 SGTC_331 k048-0133 24.5 µM -0.483879855920277 0.306199864952006 no 2354 0.314235568653138 738 6813582 SGTC_678 1218-2179 85.9 µM -0.48412276387461 0.306110101788899 no 2355 0.314149373373659 756 6820081 YOR116C RPO31 SGTC_1803 st050068 52.4 µM -0.484446706279429 0.305990411615913 no 2356 0.314034438994646 754 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1548 st061468 90.8 µM -0.485680978945665 0.305534562694666 no 2357 0.313596685876658 748 390799 SGTC_1274 0865-0114 173 µM -0.485848070710333 0.305472874509857 no 2358 0.313537444452496 733 870624 SGTC_1053 3366-3204 134 µM -0.487083586201721 0.305016909160273 no 2359 0.313099548872104 742 3632071 YPR165W RHO1 SGTC_3081 9117243 49.47 µM -0.488100994970733 0.304641662902952 no 2360 0.312739153182946 764 45595589 SGTC_3321 9137793 26.8275 µM -0.488400964782406 0.304531065602235 no 2361 0.312632929318475 732 4904192 SGTC_2294 7971431 200 µM -0.488620979044106 0.304449958852883 no 2362 0.312555028820092 791 5741572 SGTC_2775 cyproheptadine 69.59 µM -0.488628729219262 0.304447101979241 no 2363 0.312552284866529 764 2913 A selective serotonin reuptake inhibitor. SGTC_1264 0783-0040 158 µM -0.488834311749875 0.304371324395074 no 2364 0.312479502058197 734 2855798 SGTC_230 MPP+ 141.667 µM -0.489619442870743 0.304082002887929 no 2365 0.312201607788837 771 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2878 9043973 25.97 µM -0.490758618868777 0.303662433622067 no 2366 0.311798590583565 752 6465167 SGTC_1643 st009866 20.2 µM -0.492102622949403 0.303167756818554 no 2367 0.311323399055672 752 3156273 YOR207C RET1 SGTC_905 2-aminofluorene 215 µM -0.492154905573927 0.30314852085621 no 2368 0.311304920143576 742 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3126 9127922 49.47 µM -0.49535952006693 0.301970514357861 no 2369 0.3101731817514 808 45595682 SGTC_1825 st052143 62.6 µM -0.495677677526817 0.301853672935587 no 2370 0.310060919401736 773 674173 SGTC_1275 0867-0008 21.1 µM -0.496756002801398 0.301457815645118 no 2371 0.309680562396576 765 3422836 SGTC_2303 7774051 200 µM -0.496894632962307 0.30140694094168 no 2372 0.309631678235375 802 2953184 SGTC_1192 1488-0095 21.4 µM -0.496969090208525 0.301379618105679 no 2373 0.309605424299563 784 915875 SGTC_1465 k213-0056 144 µM -0.497832587509426 0.301062830563338 no 2374 0.309301022536475 762 24048857 YMR208W ERG12 SGTC_3316 9136639 10.545 µM -0.501964023841426 0.299549229604726 no 2375 0.307846413876875 762 4903665 SGTC_793 0488-0545 106 µM -0.501976723984375 0.299544582077157 no 2376 0.307841947008446 760 292548 SGTC_2222 6885208 172.143 µM -0.502333352752066 0.299414089645515 no 2377 0.307716525893361 736 609514 SGTC_1773 st048542 73.5835 µM -0.502533260592168 0.299340953541139 no 2378 0.307646231059254 776 3237138 SGTC_2044 5102272 200 µM -0.502878505725762 0.299214665002064 no 2379 0.307524847000594 752 592666 SGTC_1998 st075797 76.8 µM -0.50700798681317 0.29770600416117 no 2380 0.306074607303896 767 24208315 SGTC_596 1155-0152 116 µM -0.507888397487824 0.297384805123078 no 2381 0.305765805986811 755 280313 SGTC_1020 4335-0961 93.3 µM -0.508319698074179 0.297227512102376 no 2382 0.305614579010511 774 669075 SGTC_1135 dihydrocapsaicin 536.708 nM -0.511086003663955 0.296219560533716 no 2383 0.304645418038802 776 107982 A Capsaicinoid. SGTC_2569 tetrandrine 100 µM -0.512061715326598 0.295864417426893 no 2384 0.304303908829521 737 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_361 000s-0510 1.45 µM -0.512112022070818 0.295846111896198 no 2385 0.304286305569133 756 660 SGTC_2084 5306078 60.6385 µM -0.51245729141532 0.295720489926684 no 2386 0.304165501677619 770 679340 SGTC_1587 estradiol valerate 56.1 µM -0.513265681668734 0.295426463078414 no 2387 0.303882743249179 776 13791 A steroid. SGTC_1896 st058441 89 µM -0.513513973695823 0.295336181567435 no 2388 0.303795919300563 736 688759 SGTC_3040 9091894 49.47 µM -0.51395042884029 0.295177512809765 no 2389 0.303643324402967 732 25236966 SGTC_43 0570-0105 72.5 µM -0.514883727943989 0.294838353326314 no 2390 0.303317136140455 782 1114046 YDL195W SEC31 SGTC_158 k038-0087 26.446 µM -0.515347776228111 0.294669785771278 no 2391 0.303155009469593 718 X158 SGTC_3271 9137798 49.47 µM -0.515477175801741 0.294622788741149 no 2392 0.303109807460123 743 6498326 SGTC_1898 st060199 18.6 µM -0.515929068293462 0.294458691643004 no 2393 0.30295197550263 756 688866 SGTC_1634 st006576 41 µM -0.517151086297342 0.294015147955591 no 2394 0.302525347063605 778 3915356 SGTC_1046 2001-0062 216 µM -0.517432709494537 0.29391297380217 no 2395 0.302427065544164 772 739778 SGTC_3133 9127736 49.47 µM -0.518088385142601 0.293675155393015 no 2396 0.302198301822163 750 27243420 SGTC_148 3253-0744 288.01 µM -0.518689377822056 0.29345724916894 no 2397 0.301988685107788 744 6893655 SGTC_943 3253-1379 105 µM -0.519095096601221 0.293310187162382 no 2398 0.301847213769216 782 668464 SGTC_2417 cerulenin 830 nM -0.519310664979963 0.293232063394345 no 2399 0.301772058681732 777 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1055 3448-0672 86 µM -0.519497057337858 0.293164521035613 no 2400 0.301707082213104 764 748378 SGTC_3108 9121785 49.47 µM -0.519886504915349 0.293023421542063 no 2401 0.301571340901274 739 17140271 SGTC_1265 0819-1001 68.8 µM -0.521004447201607 0.292618558613213 no 2402 0.301181836676418 761 3106768 SGTC_495 decylubiquinone 155 µM -0.521488640265061 0.292443288729492 no 2403 0.301013208492058 789 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1242 0402-0103 60.1 µM -0.521497897264468 0.292439938324236 no 2404 0.30100998500468 772 432868 SGTC_582 0987-0078 156 µM -0.522664700553708 0.292017777703087 no 2405 0.300603803530201 780 1625765 SGTC_1491 4138-0063 26.5 µM -0.522968349717417 0.291907961066632 no 2406 0.300498139358556 769 23883227 SGTC_1042 0350-0096 82 µM -0.523254291783011 0.291804565901547 no 2407 0.300398652261311 754 3122515 SGTC_1072 oxiconazole 14.9 nM -0.523266594342716 0.291800117742765 no 2408 0.300394372196861 751 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.524614588553432 0.291312923478532 no 2409 0.299925571588047 788 756377 SGTC_2232 chlorophetanol 41.5365 µM -0.52627530171645 0.29071322830697 no 2410 0.299348470415336 766 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2995 9067767 71.4286 µM -0.526290917836554 0.290707591957518 no 2411 0.299343046172981 774 11673567 SGTC_974 1326-0144 138 µM -0.526485380261936 0.290637408626313 no 2412 0.299275503595087 771 5411856 SGTC_287 k060-0039 29.6 µM -0.529573917696576 0.289523790360678 no 2413 0.29820369105098 771 5861974 SGTC_140 0062-0056 502.533 µM -0.531332299372674 0.288890676043644 no 2414 0.29759426337122 764 3758964 SGTC_2776 terbinafine 19.92 µM -0.532361468698115 0.288520420892841 no 2415 0.297237833267973 747 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_235 0330-0087 5 mM -0.533620824413225 0.288067658076243 no 2416 0.296801948824513 754 46494818 YHR062C RPP1 SGTC_3279 9140807 49.47 µM -0.535073823788056 0.287545693606907 no 2417 0.296299404870958 781 45595718 SGTC_1373 2887-0003 58.5 µM -0.537553512069378 0.286655943350089 no 2418 0.295442665934468 769 776948 SGTC_1079 idarubicin 2.36 µM -0.538488349630535 0.28632084847639 no 2419 0.295119973077785 791 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_689 0833-0039 98 µM -0.539340767106918 0.286015459480033 no 2420 0.294825872033223 811 5374726 SGTC_90 0870-0863 4.608 µM -0.539742725950659 0.285871506531278 no 2421 0.294687235100861 804 1738164 SGTC_2319 6033012 152.6 µM -0.539876687225374 0.285823538825214 no 2422 0.294641038095816 763 847246 SGTC_2337 9009472 200 µM -0.540549633338767 0.285582633969372 no 2423 0.29440902087853 779 5742383 SGTC_2813 7971799 71.43 µM -0.540810982793346 0.285489100750733 no 2424 0.294318936003193 773 2234054 SGTC_1090 efavirenz 20.7 µM -0.54106446929518 0.285398395504904 no 2425 0.294231573581926 755 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1924 st058459 75.1 µM -0.541837105700065 0.285122007200397 no 2426 0.29396536356338 774 688683 SGTC_2695 st077686 51.995 µM -0.542147417653341 0.285011038005569 no 2427 0.293858477680468 762 2876092 SGTC_2551 apiole 73.87 µM -0.543706574685477 0.284453787131415 no 2428 0.293321703694079 766 10659 A possible DNA adduct former. SGTC_1788 fluconazole 20 µM -0.544668723277515 0.284110170102472 no 2429 0.292990689836165 797 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1147 3809-1045 12.3 µM -0.544743320023081 0.284083537281575 no 2430 0.29296503310341 759 325925 SGTC_1019 4262-0212 3.4 µM -0.545573659055018 0.283787167058334 no 2431 0.292679517509615 785 4677213 SGTC_2359 9039622 200 µM -0.546339729693125 0.283513867307114 no 2432 0.292416215558713 778 6463596 SGTC_3214 9129694 49.47 µM -0.549471180668354 0.282398019135237 no 2433 0.29134106849631 801 17158655 SGTC_1696 st025591 34.7925 µM -0.549484375582482 0.282393321787395 no 2434 0.29133654208231 788 2787147 SGTC_2479 5617353 43.85 µM -0.549503286260964 0.282386589710989 no 2435 0.291330054976448 798 2731746 SGTC_3003 9075612 71.4286 µM -0.550530541480954 0.282021009695534 no 2436 0.290977767399286 799 6501993 SGTC_1195 1502-0147 41.1 µM -0.552046909167324 0.281481781057545 no 2437 0.290458107350865 772 817940 SGTC_1473 k844-0725 134 µM -0.552740617681206 0.281235260459648 no 2438 0.290220517972797 781 54682906 SGTC_1539 benzyladenosine 56 µM -0.554956502178249 0.280448508957556 no 2439 0.289462206560429 760 92208 A nucleotide analog. SGTC_1092 toremifene 6.32 µM -0.555340470383147 0.280312289133498 no 2440 0.289330901110087 808 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1224 0823-0416 294 µM -0.555397423473615 0.280292086700382 no 2441 0.289311427268891 787 3598164 SGTC_264 promethazine 12.5 mM -0.555741370650126 0.280170096550957 no 2442 0.289193835284307 809 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2582 agaric acid 100 µM -0.556626163486044 0.279856399151719 no 2443 0.288891437055615 781 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1063 disulfiram 1.84 µM -0.557903033277953 0.279403994025633 no 2444 0.288455300065968 781 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2334 9017922 200 µM -0.559482495016097 0.278844870129591 no 2445 0.28791623731304 782 3163164 SGTC_1391 3442-0225 151 µM -0.559579703289854 0.278810476536783 no 2446 0.287883076137843 766 5227075 SGTC_536 3852-0578 10.6 µM -0.560542504149751 0.278469936198526 no 2447 0.287554728204232 771 2869208 SGTC_924 2046-0044 21.3 µM -0.561133258105754 0.278261088317387 no 2448 0.287353348640318 781 3623589 SGTC_916 4466-0038 42 nM -0.562792387840468 0.277674948748024 no 2449 0.286788132182589 784 5722064 YGL116W CDC20 SGTC_2763 lisinopril 49.32 µM -0.563702022910614 0.277353847822809 no 2450 0.286478470228025 802 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3049 9092223 49.47 µM -0.565088192911074 0.27686487962248 no 2451 0.286006889491388 790 8623917 SGTC_1075 aripiprazole 15.2 µM -0.565992018268411 0.276546284896152 no 2452 0.285699603220651 769 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3122 9126309 49.47 µM -0.566957624540685 0.276206111346614 no 2453 0.285371486059164 813 17591206 SGTC_1801 st050089 28.441 µM -0.567168028228045 0.276132015464029 no 2454 0.285300013803109 777 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_681 1642-0006 26.6 µM -0.567506786985166 0.276012738492211 no 2455 0.285184958395266 801 4446530 SGTC_3269 9137823 49.47 µM -0.570489330588097 0.274963678112116 no 2456 0.284172928293582 767 17682936 SGTC_3200 9114385 49.47 µM -0.571506590650015 0.27460632353811 no 2457 0.283828147035864 770 17018030 YLR208W SEC13 SGTC_1740 st038286 13.222 µM -0.571999001467325 0.274433426242137 no 2458 0.283661325566858 764 716786 SGTC_407 eburnamonine 100 µM -0.572566670802283 0.274234170561871 no 2459 0.283469065931133 794 3195 SGTC_1770 st043884 66.3 µM -0.57261242363099 0.274218114129032 no 2460 0.283453572971687 811 670149 SGTC_1377 2944-0135 198 µM -0.573383644782656 0.273947532765868 no 2461 0.283192480864435 780 1894137 SGTC_718 1130-0073 349 µM -0.573518496995487 0.273900233702007 no 2462 0.283146839343001 796 6740020 SGTC_2793 7325131 81.82 µM -0.575527426740559 0.273196085244234 no 2463 0.282467323579914 768 4176441 SGTC_684 1140-0066 328 µM -0.575594275454518 0.273172669579757 no 2464 0.282444725648185 801 6813534 SGTC_3168 9103419 49.47 µM -0.575755698502869 0.273116130663527 no 2465 0.282390160838208 796 16649256 SGTC_714 4296-0578 26.1 µM -0.575929257992752 0.273055347391984 no 2466 0.282331499281097 783 1589775 SGTC_195 4234-0266 16.654 µM -0.576265060603655 0.272937763060456 no 2467 0.282218017646403 789 2303354 SGTC_2414 st077232 92.9 µM -0.577058425445544 0.27266005893408 no 2468 0.281949993986394 761 729801 SGTC_2071 5230951 39.92 µM -0.578381631821438 0.272197204818539 no 2469 0.281503246134716 797 1799272 SGTC_2698 st077697 67.5 µM -0.579092793672043 0.271948603714512 no 2470 0.281263281126419 796 3154499 SGTC_134 0269-0018 6.916 µM -0.579552645107062 0.271787913427865 no 2471 0.281108167561691 775 4378915 SGTC_1682 st012968 530 nM -0.58088024796721 0.271324261747214 no 2472 0.280660582729056 764 24207270 SGTC_2273 7815444 169.05 µM -0.58121814125944 0.271206318942415 no 2473 0.280546721260364 837 2824616 SGTC_2197 6588183 93.1375 µM -0.581588211629134 0.271077173952875 no 2474 0.280422042587296 785 884136 SGTC_2157 5649910 96.377 µM -0.58194567563928 0.270952457385865 no 2475 0.28030163653967 792 2858091 SGTC_2453 5731132 22.18 µM -0.582025029385276 0.270924775330465 no 2476 0.280274910893216 817 1362040 SGTC_1717 st033143 58.0435 µM -0.582827507948875 0.270644915048338 no 2477 0.280004712517939 807 674616 SGTC_1445 4239-0156 97.7 µM -0.583317952363782 0.270473946186079 no 2478 0.27983963973174 803 4008346 SGTC_472 calcifediol 10 µM -0.583991985928548 0.270239066252854 no 2479 0.279612851926452 784 5283731 A vitamin D metabolite. SGTC_2681 menadione 3.18 µM -0.585450222028495 0.269731265165061 no 2480 0.279122513971503 806 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1146 3579-1023 7 µM -0.586217591336251 0.269464236439683 no 2481 0.27886465083913 815 X1146 SGTC_3323 9138564 53.9225 µM -0.587385961274025 0.269057922369961 no 2482 0.278472260107407 774 43912313 YNL103W MET4 SGTC_2902 5787006 60.46 µM -0.588401247779483 0.268705094682089 no 2483 0.278131500209831 784 591003 SGTC_1709 st033179 39.1045 µM -0.588675965020165 0.268609666186495 no 2484 0.278039332027948 787 573381 SGTC_2647 atorvastatin 60.16 µM -0.588709444437167 0.268598037609765 no 2485 0.278028100635568 776 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1334 1486-0610 236 µM -0.589453855091378 0.268339543031526 no 2486 0.277778429225446 778 3742339 SGTC_1646 st011709 75.6 µM -0.590188745211129 0.268084477226169 no 2487 0.277532058390456 799 5757843 SGTC_2864 9034755 47.6 µM -0.590570252300086 0.267952111811054 no 2488 0.277404200819315 781 4930451 SGTC_715 0868-0130 184 µM -0.590773390241828 0.267881645716772 no 2489 0.27733613330095 804 2876258 SGTC_2764 methyldopa 94.69 µM -0.59170745477144 0.26755775021037 no 2490 0.277023251855609 808 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_787 4152-0075 138 µM -0.594747924625147 0.266504808399853 no 2491 0.276005990844868 784 9566539 SGTC_1926 methyl fluorone black 53.6 µM -0.595563464557381 0.266222736551339 no 2492 0.275733445041448 770 72721 Reacts with homocysteine. SGTC_1399 3562-5772 25 µM -0.595922353293768 0.26609865514589 no 2493 0.275613549716439 802 23847490 SGTC_1171 0368-0077 21.4 µM -0.597523714763014 0.265545361053755 no 2494 0.275078889373107 795 3239779 SGTC_63 0099-0242 26.702 µM -0.600922994575238 0.264372796925965 no 2495 0.273945638441311 802 3898502 YLR359W ADE13 SGTC_547 1120-0019 610 nM -0.601526484650947 0.26416490195918 no 2496 0.273744688574281 788 3676939 SGTC_300 r073-0011 5.04 µM -0.601850953583 0.264053160803197 no 2497 0.273636677193711 804 2735780 SGTC_2729 fluphenazine 10.66 µM -0.602029806324147 0.263991577493832 no 2498 0.273577148517621 809 3372 An atypical antipsychotic. SGTC_71 0417-1750 47.813 µM -0.602130776629985 0.26395681421684 no 2499 0.273543544769908 757 6811472 SGTC_2576 guaiol 23.12 µM -0.603144537193277 0.263607913839646 no 2500 0.273206270184476 793 227829 SGTC_1666 st014829 29 µM -0.604455615419602 0.263157036476882 no 2501 0.272770384809917 795 3858230 SGTC_2640 pentamidine 10.38 µM -0.60453689376482 0.263129097980483 no 2502 0.272743374105959 804 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3237 9133362 49.47 µM -0.606963858485821 0.262295555604835 no 2503 0.271937448674113 815 43845137 SGTC_2146 5545642 200 µM -0.608099956712572 0.261905827307976 no 2504 0.271560590475293 785 825326 SGTC_1941 st076221 61.8 µM -0.609207678709877 0.261526119341412 no 2505 0.271193395626404 787 2828568 SGTC_975 1335-0046 28.5 µM -0.610344241189984 0.261136819309128 no 2506 0.270816898019898 823 16486740 SGTC_1841 st054148 70 µM -0.610622323981255 0.26104161462508 no 2507 0.270724820076861 815 675442 SGTC_818 4072-2707 53.5 µM -0.615316612409211 0.259437171106365 no 2508 0.269172824377438 803 882871 SGTC_3326 9140064 16.379 µM -0.618560155439601 0.258331555707542 no 2509 0.268103078662393 813 1868434 SGTC_412 gemfibrozil 100 µM -0.618674629616 0.2582925799413 no 2510 0.268065363319264 793 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1933 st074711 15.9 µM -0.619187033571902 0.258118155797759 no 2511 0.267896576403953 817 17250958 SGTC_1238 0333-0287 48.8 µM -0.619505385846701 0.258009818310807 no 2512 0.267791737476038 793 7226 SGTC_1521 st012942 49.4 µM -0.619675183644136 0.257952044588786 no 2513 0.267735828568911 783 24207259 SGTC_2101 5377231 179.231 µM -0.619994630506897 0.257843370946099 no 2514 0.267630661022932 816 2844213 SGTC_1641 st009299 47.1 µM -0.621073117278177 0.25747665269109 no 2515 0.267275758030076 796 4046054 SGTC_1508 1080-0625 72.9 µM -0.621279149731127 0.257406626237471 no 2516 0.267207984936501 805 767111 SGTC_1814 st052110 31.539 µM -0.621761713819035 0.257242650759183 no 2517 0.267049282437529 813 674163 SGTC_1609 st001574 46.4 µM -0.623213486341016 0.256749665462001 no 2518 0.266572120213827 821 3960012 SGTC_3327 9140648 26.9345 µM -0.62389501905648 0.256518403911135 no 2519 0.266348265832521 817 8029710 SGTC_2900 5328528 85.29 µM -0.625002359479969 0.256142886382382 no 2520 0.26598475476004 807 795359 SGTC_2602 kawain 100 µM -0.625241541463769 0.256061813463009 no 2521 0.265906270551493 805 5369129 SGTC_712 r015-0009 80.6 µM -0.625289441683872 0.256045578854461 no 2522 0.265890554177494 798 6813872 YLR060W FRS1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.625765760954897 0.255884171302461 no 2523 0.265734296341477 810 688761 SGTC_186 3455-3465 67.277 µM -0.625828505221611 0.255862913475051 no 2524 0.265713716384342 809 755278 SGTC_1064 honokiol 6.76 µM -0.625946463478347 0.255822951581672 no 2525 0.265675028569043 816 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_448 monastrol 171 µM -0.62684530174454 0.255518550217175 no 2526 0.265380322448095 818 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1698 5-fluorocytosine 1.055 µM -0.627233333693345 0.255387197474198 no 2527 0.26525314796979 806 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1252 0493-0875 34.8 µM -0.627478398221044 0.255304258835615 no 2528 0.265172845905469 787 3960963 SGTC_2572 astragaloside iv 100 µM -0.627946308301641 0.255145940372665 no 2529 0.265019556725284 799 45006101 An anti-inflammatory agent. SGTC_479 n-linoleoylglycine 10 µM -0.628023047608814 0.255119980351475 no 2530 0.264994420924768 822 6433346 An anti-infammatory. SGTC_1902 st060212 70.5 µM -0.629127727144121 0.254746433157626 no 2531 0.264632719714204 791 688944 SGTC_308 4092-1169 104 µM -0.63129420289508 0.254014672133541 no 2532 0.263924088340496 815 2268590 YDL196W YDL196W SGTC_1720 st037298 9.481 µM -0.632524543094705 0.253599597040605 no 2533 0.263522088096227 825 597396 SGTC_1197 1601-0112 267 µM -0.632607118314559 0.253571751723502 no 2534 0.263495118738155 815 7350313 SGTC_2625 euphol 100 µM -0.63261768458244 0.253568188771945 no 2535 0.26349166785946 808 6708538 A triterpene alcohol. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.632682544986343 0.25354631838298 no 2536 0.263470485352217 833 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2247 cerulenin 830 nM -0.632721232034818 0.253533273903724 no 2537 0.263457851113259 788 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_955 1216-0110 33 µM -0.633708344528197 0.253200559126617 no 2538 0.263135589085182 814 3619719 SGTC_2135 5326629 150.42 µM -0.633877662245651 0.253143512209257 no 2539 0.263080332273818 811 5020077 SGTC_1996 st072960 66.8 µM -0.634580925263863 0.252906639575411 no 2540 0.262850885973944 791 1719405 SGTC_913 3487-1245 167 µM -0.63565393353052 0.252545454470401 no 2541 0.262501004024439 791 4016153 SGTC_1115 galangin 695.678 nM -0.637239695785961 0.252012169348851 no 2542 0.261984362313081 834 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2240 6690706 185.951 µM -0.639635847967202 0.251207482184748 no 2543 0.261204685569308 800 805876 SGTC_1574 spiramycin 23.7 µM -0.640479889798028 0.250924356026566 no 2544 0.260930329587325 819 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1442 4112-3290 3 µM -0.641215599489311 0.250677706732733 no 2545 0.260691307936436 826 704353 SGTC_519 k048-0011 62.8 µM -0.641319269791451 0.250642961219556 no 2546 0.260657635984739 800 6836379 SGTC_379 3970-0972 5.9 µM -0.642829680267598 0.250137030608585 no 2547 0.260167311038669 816 2898042 YBL034C STU1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.643627860490255 0.249869889232493 no 2548 0.259908389716383 794 688664 SGTC_193 1273-0060 1.558 µM -0.644670536830858 0.249521146195012 no 2549 0.259570356745996 818 2847393 YHR072W ERG7 SGTC_770 0389-1121 67.2 µM -0.646029883445581 0.249066875390909 no 2550 0.259130001222788 817 6753108 SGTC_719 2810-4230 27.3 µM -0.647554272956081 0.248557973858435 no 2551 0.258636640447477 817 721079 SGTC_2744 captopril 92.04 µM -0.648136800903206 0.248363649377164 no 2552 0.258448236804016 778 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2926 9010726 65.15 µM -0.648618653869019 0.248202970106595 no 2553 0.258292447630743 818 2994293 SGTC_1675 st018485 24.5 µM -0.649056643783607 0.248056965572041 no 2554 0.258150882174423 824 3323024 SGTC_911 3456-4043 236 µM -0.65124924641765 0.247326747857592 no 2555 0.25744280261481 817 914281 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.651338390890072 0.247297083782311 no 2556 0.25741403564099 813 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2151 5563267 85.4165 µM -0.651495583977092 0.247244780209353 no 2557 0.257363313408569 830 5310824 SGTC_1292 0kpi-0043 232 µM -0.654371627405619 0.24628886617165 no 2558 0.256436204594779 818 3333905 SGTC_1296 1068-0102 11.9 µM -0.654774316310091 0.246155182280367 no 2559 0.256306534578147 813 767053 SGTC_455 paf C-16 10 µM -0.656032157350304 0.245737857365898 no 2560 0.255901716896122 810 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_903 1134-0042 114 µM -0.656388751003237 0.245619616322982 no 2561 0.255787013195153 829 701009 SGTC_2999 9069765 71.4286 µM -0.656855947320236 0.245464747369995 no 2562 0.255636773114054 797 2097066 SGTC_2134 5324836 1.464 µM -0.658730587471965 0.244843858738965 no 2563 0.25503439376588 839 699272 SGTC_1271 0832-2808 169 µM -0.659632726473179 0.244545368080782 no 2564 0.254744773733499 834 3663794 SGTC_2954 9074818 52.69 µM -0.659941606819341 0.244443213929269 no 2565 0.254645651290434 832 16648742 SGTC_1492 4158-0558 28.5 µM -0.659963685693865 0.244435912795603 no 2566 0.254638566757366 795 3967268 SGTC_1396 3511-0007 98.6 µM -0.660507279479411 0.244256192016515 no 2567 0.254464174299599 809 X1396 SGTC_3183 9108214 49.47 µM -0.661135112775384 0.244048708990554 no 2568 0.254262834543507 804 4974831 SGTC_711 k292-0785 179 µM -0.664619396255686 0.24289897112857 no 2569 0.253146980044798 817 4146315 SGTC_2642 cholecalciferol 100 µM -0.666525914018632 0.242271104389307 no 2570 0.252537502809088 824 9821465 A vitamin D precursor, similar to steriods. SGTC_668 1682-0499 62.6 µM -0.666610633793739 0.242243224352681 no 2571 0.25251043747074 832 682214 SGTC_2603 homopterocarpin 100 µM -0.666673890199333 0.242222408730477 no 2572 0.252490230009376 826 101795 A weak amylase inhibitor. SGTC_1476 4112-3294 3.34 µM -0.667654916872832 0.241899708963312 no 2573 0.252176947013203 815 704369 SGTC_721 1187-1332 279 µM -0.672615183902486 0.240271651227597 no 2574 0.250596069651658 837 25730 SGTC_1405 3909-7894 12 µM -0.672634640394523 0.240265276999143 no 2575 0.250589879063339 823 7104060 SGTC_1769 st044406 64.4 µM -0.674164617751247 0.239764322892606 no 2576 0.250103330801898 847 670903 SGTC_2795 7780010 54.55 µM -0.674381764103653 0.239693269778497 no 2577 0.250034316700005 825 953673 SGTC_2202 7226349 200 µM -0.674565040386069 0.239633308335659 no 2578 0.249976075148978 809 844334 SGTC_1125 tnp00248 1.32998 µM -0.674875735675305 0.239531678658527 no 2579 0.249877358825446 834 24207736 SGTC_1295 1013-0063 9.78 µM -0.675171813345279 0.239434852364558 no 2580 0.249783306175131 825 6826038 SGTC_1838 st055369 84.5 µM -0.676991124759838 0.238840352323577 no 2581 0.249205792755054 806 676036 SGTC_1037 k284-1091 78.7 µM -0.677980779278724 0.238517300288653 no 2582 0.248891940061028 820 3334711 SGTC_3312 9133330 71.43 µM -0.678168370178082 0.238456092138984 no 2583 0.248832472413476 843 17617324 SGTC_2996 9066192 71.4286 µM -0.678879605342831 0.238224104705234 no 2584 0.24860707453672 819 6472854 SGTC_2819 7996655 46.38 µM -0.679153382763437 0.238134838207421 no 2585 0.248520340602252 809 6456960 SGTC_3026 9090633 49.47 µM -0.680247595587845 0.237778247735495 no 2586 0.248173850045723 829 25236842 SGTC_1835 st008666 49.2 µM -0.680298437161547 0.237761686216663 no 2587 0.248157756952651 825 690455 SGTC_92 0063-0024 660.874 µM -0.681172434840851 0.237477082553552 no 2588 0.247881193908378 836 3594437 SGTC_2259 7964009 200 µM -0.681560189935655 0.237350876089555 no 2589 0.247758547513219 813 313134 SGTC_2896 9052656 71.43 µM -0.683391434962927 0.23675534074488 no 2590 0.247179765376227 829 6469436 SGTC_796 1234-0020 70.7 µM -0.684652687271091 0.236345649925318 no 2591 0.246781555679312 817 46495034 SGTC_1165 k072-0275 30.3 µM -0.685944066290165 0.235926577819336 no 2592 0.246374190336598 831 6153523 YGL055W OLE1 SGTC_580 1123-0028 41 µM -0.686106958670119 0.235873745871712 no 2593 0.246322831567066 847 1677248 YPR107C YTH1 SGTC_2010 4012422 159 µM -0.68716572462493 0.23553050841125 no 2594 0.245989150374252 828 952393 SGTC_1615 st002656 86.5 µM -0.687406775413862 0.235452401568155 no 2595 0.245913214598698 825 1584458 SGTC_2471 5466956 24.79 µM -0.690004159430729 0.234611687763196 no 2596 0.24509578581949 828 724419 SGTC_1172 0370-0043 85 µM -0.69066725341763 0.234397325730628 no 2597 0.244887336382457 828 376585 SGTC_1805 st050013 60.3 µM -0.690670044574543 0.234396423647137 no 2598 0.244886459159376 829 4037144 SGTC_2886 9058944 51.95 µM -0.691564540504981 0.234107427447318 no 2599 0.244605418249142 793 4949929 SGTC_2239 6685329 187.64 µM -0.694376635103343 0.233200174723167 no 2600 0.243723021246539 823 805680 SGTC_983 1491-0821 12.2 µM -0.694705938140859 0.233094061047562 no 2601 0.243619802955247 821 46495113 SGTC_2250 alverine citrate 130 µM -0.696537714273718 0.232504284309361 no 2602 0.243046073546615 824 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_841 0251-0215 91.2 µM -0.697612444530873 0.232158640160629 no 2603 0.242709798440084 837 3888614 SGTC_2082 5219693 150 µM -0.698252378623353 0.23195296678441 no 2604 0.24250968751804 827 2834649 SGTC_151 3013-0144 2.285 µM -0.698781054486402 0.231783128118493 no 2605 0.242344435090624 850 906558 YHR107C CDC12 SGTC_2960 9079389 5.97 µM -0.699467474688951 0.231562717030948 no 2606 0.242129966334546 821 16457355 SGTC_2446 5162541 200 µM -0.700467508935323 0.231241812958896 no 2607 0.241817694608525 843 1549321 SGTC_3213 9129884 49.47 µM -0.700571194264354 0.231208555254925 no 2608 0.24178533022916 833 17190742 SGTC_953 1188-0045 9.7 µM -0.700926388013354 0.231094644917862 no 2609 0.241674477734304 838 6144426 SGTC_408 cantharidin 100 µM -0.701374721266369 0.230950909546741 no 2610 0.24153459670976 829 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3342 9147791 14.508 µM -0.704810094602228 0.229851188933953 no 2611 0.240464212823108 828 1838168 SGTC_1150 3909-7983 10.9 µM -0.705187316250392 0.229730612848771 no 2612 0.240346836780836 842 23965914 SGTC_659 k018-0002 107 µM -0.70569263531364 0.229569146903806 no 2613 0.240189650953362 841 6797879 YHR007C ERG11 SGTC_508 roscovitine 141 µM -0.705773323767541 0.229543370195553 no 2614 0.240164556986877 858 160355 A CDKinase inhibitor. SGTC_1572 epiandrosterone 68.9 µM -0.706242486928973 0.229393523610204 no 2615 0.240018676386554 829 441302 A steroid. SGTC_748 act1.228 77.9 µM -0.706682975996079 0.229252885197071 no 2616 0.239881755636313 827 4421505 YNR035C ARC35 SGTC_2152 5568786 200 µM -0.708086734115241 0.228805018973791 no 2617 0.239445698601259 850 5399883 SGTC_1749 st037932 54.2 µM -0.708666587015612 0.228620161503073 no 2618 0.23926570214477 871 594497 SGTC_3231 9132313 49.47 µM -0.709020551762492 0.228507358559272 no 2619 0.239155861658958 842 4905967 SGTC_476 mead acid 10 µM -0.710725731412199 0.22796438321771 no 2620 0.238627105584472 860 5312531 An omega 9 fatty acid. SGTC_1314 1222-0010 41.1 µM -0.711259420471893 0.227794591425497 no 2621 0.238461746459525 849 3526027 SGTC_2433 5607874 27.82 µM -0.711522817529906 0.227710818571485 no 2622 0.238380158195921 843 2252428 SGTC_3225 9130819 49.47 µM -0.711552131835115 0.227701496293817 no 2623 0.238371078921252 855 4547121 SGTC_906 1165-0455 526 µM -0.711556187664174 0.227700206511629 no 2624 0.23836982275814 846 3252859 SGTC_1266 0828-0227 32.9 µM -0.712755382400553 0.227319034559129 no 2625 0.237998569649439 856 3913820 SGTC_9 0092-0002 10.449 µM -0.712823932506362 0.227297256324847 no 2626 0.237977357123182 851 759368 SGTC_2705 st078069 42.8 µM -0.712991187452231 0.227244124690329 no 2627 0.237925605171662 834 1530061 SGTC_565 1418-0001 44.5 µM -0.713317940085557 0.227140345854573 no 2628 0.237824519321205 855 2862145 SGTC_3 0833-0587 95.581 µM -0.715412601761448 0.226475702149364 no 2629 0.237177063970202 838 5382644 SGTC_327 1273-0057 3.96 µM -0.715768449822373 0.226362899500604 no 2630 0.237067168415885 834 3108138 SGTC_2753 fluvastatin 17.09 µM -0.716123042325703 0.226250526431669 no 2631 0.236957688451289 862 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.718361030662491 0.225542018467738 no 2632 0.23626735415101 846 803109 SGTC_496 calpeptin 138 µM -0.719816988354662 0.225081762727117 no 2633 0.235818841856737 822 73364 A calpain inhibitor. SGTC_743 1275-0778 158 µM -0.720469402281205 0.224875695143915 no 2634 0.235618016117204 847 2849257 YMR203W TOM40 SGTC_315 k915-0449 187 µM -0.720883293469117 0.224745021400913 no 2635 0.235490661256048 832 20970215 YNL149C PGA2 SGTC_2115 tiliquinol 12.7705 µM -0.720935128457295 0.224728659090973 no 2636 0.235474714239041 847 71208 A bioactive hydroxyquinoline. SGTC_1030 k029-0042 36.7 µM -0.721270684863878 0.224622753196946 no 2637 0.235371494837712 845 6080581 SGTC_2387 9077560 195.08 µM -0.721704744562633 0.224485800411013 no 2638 0.235238012217837 837 5303272 SGTC_1583 clindamycin 39.6 µM -0.723112251831692 0.224042035407785 no 2639 0.234805461350103 856 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2279 7948423 32.93 µM -0.723666986173795 0.223867273358213 no 2640 0.234635102937602 819 1247112 SGTC_2534 helenine 20.12 µM -0.724358246909962 0.223649608853622 no 2641 0.234422913084567 831 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_516 3992-2719 87.3 µM -0.725580014342174 0.223265192618826 no 2642 0.234048138356095 844 5350887 YDR037W KRS1 SGTC_1990 st072050 59.8 µM -0.726894508508308 0.222852021187971 no 2643 0.233645290743103 839 17233948 SGTC_2743 auranofin 4.32 µM -0.727425142759679 0.222685355884963 no 2644 0.233482778434032 802 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2114 5491910 81.25 µM -0.729805804865847 0.221938495913459 no 2645 0.232754447863512 844 2849228 SGTC_162 k030-0015 37.8 µM -0.731257463619965 0.221483785254602 no 2646 0.23231095338961 866 1809920 YMR134W ERG29 SGTC_1812 st052057 4.327 µM -0.731896943721209 0.221283646662023 no 2647 0.232115735881951 854 3645418 SGTC_3234 9132280 49.47 µM -0.732149707646945 0.221204567468241 no 2648 0.232038598474477 831 17612295 SGTC_3017 9080681 49.47 µM -0.733976665856149 0.22063347007304 no 2649 0.231481479805932 851 16451914 SGTC_847 0342-0274 5.54 µM -0.735111604580603 0.220279120028016 no 2650 0.231135763732908 855 18097 SGTC_2756 carbadox 75.1 µM -0.73614416052747 0.219957019550521 no 2651 0.230821485160835 844 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2740 felodipine 17.08 µM -0.736601807428493 0.219814345451536 no 2652 0.230682267751751 811 3333 L-type calcium channel blocker SGTC_383 2324-0395 7.37 µM -0.738456141155126 0.219236790039594 no 2653 0.230118654867158 819 3146421 SGTC_2382 9035899 200 µM -0.739617645512949 0.218875469737862 no 2654 0.229766015828452 852 6462679 SGTC_1679 SEC14.276 6.7 µM -0.739932966550842 0.2187774389578 no 2655 0.229670334899323 842 1005053 YMR079W SEC14 SGTC_94 0334-0113 514.748 µM -0.744877555249857 0.217243513909212 no 2656 0.228172872397237 854 6795178 SGTC_1345 1488-0192 31.4 µM -0.745353273823128 0.217096263365828 no 2657 0.228029091668945 852 658348 SGTC_2711 st079103 59.1 µM -0.748387451163484 0.2161584435778 no 2658 0.22711324474492 863 54693780 SGTC_40 0327-0103 19.753 µM -0.749067441339497 0.215948590830873 no 2659 0.226908278887731 855 409036 SGTC_1312 1218-2183 165 µM -0.750005934225718 0.215659155157453 no 2660 0.226625565363351 848 6744073 SGTC_2217 6934799 96.0675 µM -0.750409143553344 0.215534872588958 no 2661 0.226504162843062 850 675606 SGTC_27 0485-0001 32.618 µM -0.750706954924905 0.215443103863941 no 2662 0.226414518232905 836 2054479 SGTC_2790 5423970 71.43 µM -0.750812337172028 0.215410636408811 no 2663 0.226382801777883 866 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1514 1189-1591 158 µM -0.751011018158842 0.215349432054882 no 2664 0.226323012416052 873 767698 YMR146C TIF34 SGTC_2881 9058953 51.95 µM -0.751469704094753 0.215208170834487 no 2665 0.22618501345407 817 17122249 SGTC_1663 st014140 55.4 µM -0.751566861731212 0.215178256162081 no 2666 0.226155788983854 851 4207120 SGTC_3310 9130229 44.1445 µM -0.751926499821558 0.215067545205889 no 2667 0.226047630439967 872 7761258 SGTC_566 0958-0068 16.5 µM -0.754506307398814 0.21427434757766 no 2668 0.225272629715495 847 6815365 SGTC_2102 5377816 72.7585 µM -0.754731452549655 0.214205204408925 no 2669 0.225205065266118 847 1379702 SGTC_1386 3228-0095 33.8 µM -0.755253117686629 0.214045048405288 no 2670 0.225048561406995 843 870181 SGTC_3354 9151612 71.43 µM -0.755840893611316 0.213864679310666 no 2671 0.224872297628138 836 27261949 SGTC_447 ml7 120 µM -0.757815188553933 0.213259481403445 no 2672 0.224280814193083 868 4216 Selective myosin light chain kinase inhibitor. SGTC_364 0083-0097 67.7 µM -0.758502392922694 0.213049061158945 no 2673 0.224075140518166 867 5207356 SGTC_313 3474-0040 5.03 µM -0.759338107829661 0.212793330651667 no 2674 0.223825163492629 853 1043375 YIL048W NEO1 SGTC_703 3875-0075 71.8 µM -0.759540614810515 0.212731390074511 no 2675 0.223764613959854 883 2850814 SGTC_1985 st071382 65.5 µM -0.759874821230384 0.212629189766395 no 2676 0.22366470669722 876 6123237 SGTC_2852 9023854 51.95 µM -0.760468936810886 0.212447580057669 no 2677 0.223487165141515 868 19798528 SGTC_3048 9093155 49.47 µM -0.76285119695277 0.211720279745353 no 2678 0.222776072090798 825 25236002 SGTC_173 1273-0061 2.693 µM -0.763902167505533 0.211399883859552 no 2679 0.222462772835721 844 2847414 YPL266W DIM1 SGTC_698 k064-0052 127 µM -0.765795424732734 0.210823427944451 no 2680 0.221899018495465 894 5088751 SGTC_1452 4194-0072 190 µM -0.766244826282854 0.210686730390606 no 2681 0.221765320317526 880 1343545 SGTC_1038 k292-0204 154 µM -0.766589340284105 0.210581972421682 no 2682 0.22166285763864 862 4454212 SGTC_2264 7948757 110.76 µM -0.767142173275447 0.210413933823709 no 2683 0.221498494889832 850 2971411 SGTC_2662 daunorubicin 22.37 µM -0.767691359682824 0.210247081602225 no 2684 0.221335285310349 830 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3176 9106582 49.47 µM -0.768209238122067 0.210089812482214 no 2685 0.221181442991719 815 17018027 SGTC_68 0986-0284 82.829 µM -0.768402458775865 0.210031153018015 no 2686 0.221124060034449 839 423278 YIL048W NEO1 SGTC_3039 9090270 49.47 µM -0.768419598252566 0.210025950143956 no 2687 0.221118970338498 833 17173750 SGTC_3071 9117417 49.47 µM -0.768649718599201 0.209956101951082 no 2688 0.221050640870458 866 45595590 YGL055W OLE1 SGTC_117 lucigenin 22.078 µM -0.769197294921561 0.209789951570161 no 2689 0.220888098024311 870 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2841 9004761 38.96 µM -0.771438233912267 0.209110792279748 no 2690 0.220223609969411 849 2991039 SGTC_2424 5537928 59.2 µM -0.771616771690713 0.209056738739778 no 2691 0.220170718908418 862 5382802 SGTC_2314 7727897 200 µM -0.772123450241887 0.208903383142555 no 2692 0.220020657213419 835 900724 SGTC_2703 st077852 53.4 µM -0.772707130799064 0.208726803640549 no 2693 0.219847862785053 873 6281836 SGTC_1799 st045822 46.1415 µM -0.777159323871684 0.207382789364291 no 2694 0.218532388618544 851 3674992 SGTC_2272 7805186 180 µM -0.777310256636267 0.20733731609316 no 2695 0.218487872605113 897 2956062 YPR165W RHO1 SGTC_2415 st077333 57.7 µM -0.778634134505363 0.206938708700659 no 2696 0.21809763275211 862 2766255 SGTC_1778 st046819 58.9 µM -0.778782522027038 0.206894058871457 no 2697 0.218053917573534 880 671715 SGTC_2521 angolensin 13.4 µM -0.778806479579922 0.206886850574577 no 2698 0.218046860117411 867 821428 A flavenoid. SGTC_3047 9092122 49.47 µM -0.782097896224712 0.205897949916078 no 2699 0.217078521513296 874 17173831 SGTC_2669 eugenol 100 µM -0.782799991229918 0.205687370081026 no 2700 0.216872286365078 843 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1579 chlormadinone acetate 49.4 µM -0.783573459927144 0.205455531124138 no 2701 0.216645216911454 874 45114258 A steroidal progestin. SGTC_1602 st001878 87.6 µM -0.783982887952199 0.205332872295719 no 2702 0.216525075620355 869 595405 YLR310C CDC25 SGTC_2243 6634756 200 µM -0.786341793757848 0.204627025250922 no 2703 0.215833636867356 844 885676 SGTC_3250 9135583 49.47 µM -0.78950780251221 0.203681944059765 no 2704 0.214907635630605 861 7699353 SGTC_1772 st048439 82.2 µM -0.790071939735886 0.203513817784971 no 2705 0.214742878085797 854 2927068 YDL195W SEC31 SGTC_2442 5158906 48.48 µM -0.790216856700584 0.203470642458708 no 2706 0.214700566611781 853 1893835 SGTC_314 1671-0008 2.74 µM -0.790939204478041 0.203255513823808 no 2707 0.21448973466475 867 3913060 SGTC_720 r052-1644 49.9 µM -0.791187277189646 0.203181664472223 no 2708 0.214417357355981 864 1422863 YOR257W CDC31 SGTC_433 pimozide 108 µM -0.793125294986532 0.202605282904495 no 2709 0.213852413366124 865 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_749 1000-0129 128 µM -0.793143055812545 0.20260000521993 no 2710 0.213847239988419 885 708470 SGTC_2122 5258151 111.688 µM -0.794180388918167 0.20229190104413 no 2711 0.213545211796863 865 2173356 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.795972709733141 0.201760214609053 no 2712 0.213023948823558 876 4213774 SGTC_1875 nocodazole 6 µM -0.796035393170721 0.201741634919267 no 2713 0.213005731964246 858 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_653 0203-0016 55.2 µM -0.797075031565212 0.201433630263799 no 2714 0.212703728169938 876 295302 SGTC_1424 4048-1941 275 µM -0.803059357011162 0.199666192573786 no 2715 0.210970213762489 868 X1424 SGTC_637 1181-0519 7.26 µM -0.805154828289499 0.199049519062728 no 2716 0.210365169839832 875 6252091 YGR060W ERG25 SGTC_1761 st044296 37 µM -0.806281643078662 0.198718385201076 no 2717 0.210040236299082 885 1826700 SGTC_2737 bleomycin 30.5 nM -0.806412509734842 0.19867994932843 no 2718 0.210002518105148 865 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3180 9109287 49.47 µM -0.807939423377255 0.198231822255787 no 2719 0.209562727523719 858 18891271 SGTC_2917 7979103 53.79 µM -0.809260713987369 0.197844535410765 no 2720 0.209182599280127 866 2980565 SGTC_2921 7974240 10.71 µM -0.810303601926771 0.197539174915574 no 2721 0.208882852848872 856 2979074 YDR527W RBA50 SGTC_3179 9107801 49.47 µM -0.811462360593758 0.197200221535502 no 2722 0.208550099860044 847 4818259 SGTC_2909 7941780 10.49 µM -0.812037329332924 0.197032165705679 no 2723 0.20838510600528 861 1243215 SGTC_1215 3852-0577 11.2 µM -0.815826467011226 0.195926819862766 no 2724 0.207299696689797 861 2884876 SGTC_881 0833-0569 170 µM -0.81624091093133 0.195806149304902 no 2725 0.207181181202826 877 5418700 SGTC_696 1560-0013 611 µM -0.819088033032435 0.194978393780399 no 2726 0.206368094512134 860 1650269 SGTC_3006 9075424 71.4286 µM -0.81966834955705 0.194809937363261 no 2727 0.206202598874002 875 7465181 SGTC_2254 7938975 95.19 µM -0.820169875208298 0.194664423985539 no 2728 0.206059636347558 880 2969277 SGTC_2785 7756463 72.73 µM -0.821074162269859 0.194402220003657 no 2729 0.205802013144847 891 2201551 SGTC_2641 levomentholum 100 µM -0.82123406173611 0.194355878482163 no 2730 0.205756479126143 864 16666 SGTC_1346 1488-2224 62.4 µM -0.821620771182024 0.1942438314666 no 2731 0.205646381928583 863 3722427 SGTC_1479 0549-0158 134 µM -0.822295618288299 0.194048392337596 no 2732 0.205454334958168 892 5440202 SGTC_2052 5265182 7.135 µM -0.826801464780313 0.192746549295977 no 2733 0.204174799842233 856 1239884 SGTC_2367 9070478 135.38 µM -0.826842783248953 0.192734636182134 no 2734 0.204163088548683 866 572802 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.826992379367382 0.19269150776638 no 2735 0.20412069041933 871 2333 A French combination drug. SGTC_1000 4048-0884 8.67 µM -0.827109913368555 0.192657626965181 no 2736 0.204087382928196 898 13040088 SGTC_62 0180-0423 3.232 µM -0.827439341235415 0.19256268423062 no 2737 0.203994044936536 888 30102 YGL099W LSG1 SGTC_1232 0279-0259 161 µM -0.828068698053085 0.192381380022019 no 2738 0.203815797714124 869 1560000 SGTC_1444 4112-3581 28 µM -0.82844349936843 0.19227345740608 no 2739 0.203709690138671 887 2877249 SGTC_1487 3970-0795 2.82 µM -0.828491788365822 0.192259555465887 no 2740 0.203696021748423 870 3765103 SGTC_2964 9083345 53.42 µM -0.828837906002527 0.192159929507955 no 2741 0.203598067799577 865 17741579 SGTC_675 1309-0189 238 µM -0.830187533341655 0.191771756665742 no 2742 0.203216381313213 868 4246530 SGTC_35 0133-0054 64.071 µM -0.838191347182358 0.189479621644713 no 2743 0.200961622970636 884 99677 SGTC_591 4299-0174 154 µM -0.838983085095472 0.18925380342621 no 2744 0.200739400806955 890 5509088 SGTC_2770 toltrazuril 17.5 µM -0.840784346316974 0.188740668212192 no 2745 0.200234379067815 848 68591 Kills coccidiodes. SGTC_3014 9081533 49.47 µM -0.843018851240871 0.188105305469635 no 2746 0.199608950435017 894 21367265 SGTC_3182 9108849 49.47 µM -0.848779653081618 0.186473368154611 no 2747 0.198001957043343 876 17133045 SGTC_2260 7964312 200 µM -0.849224089758501 0.186347832197128 no 2748 0.197878305563579 878 231951 SGTC_990 3985-0011 41.3 µM -0.849738571966536 0.186202576522963 no 2749 0.197735224239054 887 5399565 YGL099W LSG1 SGTC_2470 5664817 21.68 µM -0.84999971473336 0.186128873969453 no 2750 0.197662622422516 891 2859561 SGTC_2130 NSC 7 2.4545 µM -0.850899053703853 0.185875191129277 no 2751 0.197412715285695 879 21448 SGTC_1596 piperlongumine 63 µM -0.851156305777546 0.1858026656936 no 2752 0.197341265575674 879 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1289 0976-0073 69.1 µM -0.853087904879875 0.185258663118288 no 2753 0.196805279130288 892 3391136 SGTC_927 2425-1185 123 µM -0.85359341802303 0.185116457253915 no 2754 0.196665153362584 900 730375 SGTC_2076 5212012 200 µM -0.853773711054214 0.185065755443082 no 2755 0.196615191641671 879 604802 SGTC_3068 9116768 49.47 µM -0.854476004913279 0.184868339388169 no 2756 0.196420649512151 884 41904888 SGTC_1972 st070201 17.4 µM -0.855126928340906 0.1846854805698 no 2757 0.196240441699268 895 2829099 SGTC_1822 st052468 42 µM -0.855443324400174 0.184596638532869 no 2758 0.196152883831308 895 2873678 SGTC_77 0828-0286 12.516 µM -0.855983461659403 0.184445032787924 no 2759 0.196003463694364 901 745345 SGTC_1531 st059297 52.4 µM -0.85608950546157 0.184415277507995 no 2760 0.195974136521938 892 7566702 SGTC_1710 st031758 61.5 µM -0.85850111820779 0.183739399207618 no 2761 0.1953079066469 882 5394341 SGTC_1753 st043925 64 µM -0.858643301978098 0.183699599033338 no 2762 0.195268670096341 906 670181 SGTC_2105 5350118 200 µM -0.858830060346528 0.183647329670144 no 2763 0.195217140168783 891 2133313 SGTC_279 1273-0055 2.93 µM -0.858979387801629 0.183605543024906 no 2764 0.195175944036149 909 2847562 SGTC_713 1488-1073 324 µM -0.859691824490523 0.183406261805225 no 2765 0.1949794713009 891 3312542 SGTC_2144 5628481 200 µM -0.859820789485387 0.183370202420497 no 2766 0.194943918745952 866 2818399 SGTC_616 4092-0450 108 µM -0.859987954249156 0.183323468730158 no 2767 0.194897841297738 913 787165 SGTC_2086 5274770 176.623 µM -0.863483540649373 0.182347921347065 no 2768 0.193935832582883 887 689278 SGTC_2663 amphotericin b 100 µM -0.863644742513331 0.182303011550737 no 2769 0.193891538666221 878 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1804 st050076 49.1 µM -0.864641816110908 0.182025386905423 no 2770 0.193617706814273 899 3895976 SGTC_454 lyso-paf C-16 6.67 µM -0.865491837195003 0.181788916343169 no 2771 0.193384447142082 890 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2320 7373003 200 µM -0.867582741833095 0.181208057934334 no 2772 0.19281139880168 881 5415828 SGTC_3199 9111318 49.47 µM -0.869976552932099 0.180544480358175 no 2773 0.192156608949766 862 8548020 SGTC_422 cantharidin 155 µM -0.870341968785462 0.180443319328159 no 2774 0.192056774937938 902 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3195 9113082 49.47 µM -0.874892225196426 0.179186614608067 no 2775 0.190816274909022 880 17018038 SGTC_37 0566-0070 1.56 µM -0.875485327832481 0.179023216083507 no 2776 0.190654945026343 895 1626686 SGTC_802 4112-3352 742 µM -0.875953773651845 0.17889422653683 no 2777 0.190527582246712 870 704594 SGTC_277 nystatin 15.5 µM -0.876399954003516 0.178771422332492 no 2778 0.190406321669259 913 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1120 ficusin 1.78878 µM -0.876822946572526 0.178655049221854 no 2779 0.190291406722742 916 6199 A DNA cross-linker. SGTC_1412 3909-8563 178 µM -0.879312982307115 0.177970961411662 no 2780 0.189615799366628 912 23767530 SGTC_3056 9094900 49.47 µM -0.880558889980232 0.177629293893606 no 2781 0.189278308845518 900 25236784 SGTC_597 k018-0003 82.8 µM -0.880587400130114 0.177621480350852 no 2782 0.189270590368285 913 6786234 SGTC_1981 st071826 47 µM -0.880777367256716 0.17756942315723 no 2783 0.189219166019334 873 11838600 SGTC_413 propylparaben 100 µM -0.882192774776238 0.177181858488503 no 2784 0.188836284247711 893 7175 A pharmaceutical preservative. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.882708615101089 0.177040744842199 no 2785 0.188696863110121 937 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_789 1309-1135 70.6 µM -0.883422558634069 0.176845555124886 no 2786 0.188504003421892 879 3092424 SGTC_2004 4023728 41.89 µM -0.887731738946996 0.175670329789078 no 2787 0.187342534448837 914 360084 YDR527W RBA50 SGTC_2061 5245884 80.95 µM -0.888902124899647 0.175351991628802 no 2788 0.18702784168296 910 573863 SGTC_1418 3966-3099 2.4 µM -0.889974309408981 0.17506068490315 no 2789 0.186739840459152 877 740335 SGTC_1725 st036284 20.55 µM -0.894364234369544 0.173871170363098 no 2790 0.185563521034986 889 707914 SGTC_856 0433-0016 11.3 µM -0.895019997822261 0.173693923928515 no 2791 0.185388198978485 896 3911780 SGTC_2844 9010103 25.97 µM -0.895072244972779 0.173679806981607 no 2792 0.185374234832538 898 2480525 SGTC_1216 1165-0504 9.65 µM -0.895847741033782 0.173470357237057 no 2793 0.185167044041293 909 6304004 SGTC_666 0272-0154 136 µM -0.898547619415917 0.172742415771582 no 2794 0.184446834948734 897 6870312 SGTC_1807 st050092 58.9 µM -0.8989024453588 0.172646892539794 no 2795 0.184352312676536 906 5008496 SGTC_1848 st056003 16.4 µM -0.899123684038933 0.172587349586945 no 2796 0.184293392043207 875 146492 SGTC_409 arachidonic acid 100 µM -0.899720685122011 0.172426741371075 no 2797 0.18413445625729 901 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2153 5569715 200 µM -0.900357277575257 0.172255587147435 no 2798 0.183965074338522 904 2054701 SGTC_859 0439-0102 54.6 µM -0.903314378394963 0.171461963081073 no 2799 0.183179533785804 895 610143 SGTC_2967 9089538 49.85 µM -0.904650066875556 0.171104259573413 no 2800 0.182825401094362 899 728216 SGTC_411 enrofloxacin 100 µM -0.906036278061597 0.1707335309241 no 2801 0.182458325479671 897 71188 A bacterial gyrase inhibitor. SGTC_2862 9027634 71.43 µM -0.906333976450362 0.170653981507093 no 2802 0.18237955356036 889 5012562 SGTC_2245 6637752 200 µM -0.907084622867431 0.170453503030547 no 2803 0.182181024535516 914 681890 SGTC_1931 st074438 57.1 µM -0.907436519587601 0.17035957235644 no 2804 0.182088002322174 917 2787313 SGTC_3242 9133940 49.47 µM -0.907851571979847 0.17024882636271 no 2805 0.181978323382556 904 17248444 SGTC_2906 7926292 26.41 µM -0.908023588649757 0.17020294168665 no 2806 0.181932879531013 916 2966319 SGTC_614 0462-0418 107 µM -0.909268783824351 0.169871027767213 no 2807 0.181604132000077 883 5188303 SGTC_1082 camptothecin 424.86 nM -0.909890866403161 0.169705363648507 no 2808 0.181440033545222 889 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1003 4049-0218 100 µM -0.910303486331489 0.169595537801771 no 2809 0.181331240225903 905 295161 SGTC_2171 5739187 198.077 µM -0.911245555069106 0.169344961039197 no 2810 0.181083003063678 886 2262761 SGTC_2566 crystal violet carbinol 226 nM -0.912922896223095 0.168899400904 no 2811 0.180641547307724 924 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1667 st014849 34.6 µM -0.913361314263179 0.1687830660914 no 2812 0.180526272363079 903 5348460 SGTC_3076 9116187 49.47 µM -0.913401198389878 0.168772485340858 no 2813 0.180515787766111 893 27241210 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.914150115440613 0.168573886338199 no 2814 0.180318986047363 909 5357218 A potent inhibitor of glutathione S-transferases. SGTC_884 0851-0618 334 µM -0.914372233967674 0.168515013495321 no 2815 0.18026064325285 910 9642473 SGTC_2356 9061756 188.97 µM -0.91437468465851 0.168514364009843 no 2816 0.180259999607876 891 20104043 SGTC_1563 conessine 56.1 µM -0.91515084143929 0.168308746837879 no 2817 0.180056223772549 910 441082 An anti-amoebic, histamine inhibitor. SGTC_931 2812-0076 566 µM -0.917105902212553 0.16779153340387 no 2818 0.179543574258922 917 3450959 SGTC_555 4296-0685 37 µM -0.918738864885437 0.167360316580163 no 2819 0.179116088090663 911 2908540 YHR072W ERG7 SGTC_1504 k297-0033 30 µM -0.919687827339094 0.16711005224635 no 2820 0.178867957766981 849 4388117 SGTC_2869 9037858 32.47 µM -0.920431996202722 0.166913965821965 no 2821 0.178673527355208 899 27187042 SGTC_828 2074-0507 139 µM -0.921265496673286 0.166694517042842 no 2822 0.178455915167688 899 X828 SGTC_1202 1988-0068 29.6 µM -0.922753189168499 0.166303291779579 no 2823 0.178067920197405 903 2850480 SGTC_3095 9117207 49.47 µM -0.923330588452513 0.166151610324953 no 2824 0.177917475985914 907 17015229 SGTC_2436 5633522 8.09 µM -0.923796083401079 0.166029390969237 no 2825 0.17779624737702 920 5724242 SGTC_2123 5259487 200 µM -0.924769742069982 0.165773937119 no 2826 0.177542846479632 900 2173474 SGTC_2977 9011197 71.43 µM -0.925536957231746 0.165572825889226 no 2827 0.17734333447883 888 2704722 SGTC_3224 9130643 49.47 µM -0.92627834235842 0.16537863550393 no 2828 0.17715067404966 905 17644395 SGTC_2978 9011784 42.97 µM -0.92815018442959 0.164889001456348 no 2829 0.17666483539087 885 2994934 SGTC_1777 st045864 34.765 µM -0.928758634618874 0.164730046230308 no 2830 0.176507093085911 932 4691462 SGTC_554 4483-2211 187 µM -0.928867503910002 0.164701615028798 no 2831 0.176478877836061 924 747107 SGTC_524 r073-0010 27.8 µM -0.93003210231095 0.164397679220135 no 2832 0.176177231705506 912 2772106 SGTC_1294 1000-1494 117 µM -0.930989725676236 0.164148032151636 no 2833 0.175929439445237 909 712797 YDL207W GLE1 SGTC_66 0109-0187 42.4 µM -0.931504298646717 0.164013987462853 no 2834 0.175796381017285 901 759417 SGTC_2918 7977171 22.06 µM -0.931608570155084 0.163986833708676 no 2835 0.175769426229763 900 2236483 SGTC_900 1112-0045 141 µM -0.93203711071925 0.163875266400857 no 2836 0.175658673510492 895 56211 YIL048W NEO1 SGTC_1094 duloxetine 25.4 µM -0.934944565289508 0.163119633626032 no 2837 0.174908434295923 896 60834 A selective serotonin reuptake inhibitor. SGTC_1270 0831-1170 17.3 µM -0.938718082084504 0.162142297907425 no 2838 0.173937753562713 901 6764716 SGTC_1954 st077032 68.9 µM -0.939137573326809 0.162033886243163 no 2839 0.173830057676977 927 698907 SGTC_1665 st014639 11.4 µM -0.939800535457791 0.161862649210809 no 2840 0.173659942063794 900 981133 YIL048W NEO1 SGTC_2121 5257820 149.641 µM -0.940575206749022 0.161662708163278 no 2841 0.173461296202787 905 791256 SGTC_2747 doxorubicin 7.63 µM -0.941006393064226 0.161551489640978 no 2842 0.173350791499486 831 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3001 9076041 71.4286 µM -0.942381758055998 0.161197066746161 no 2843 0.172998611637961 907 16004211 SGTC_1569 carminic acid 40.6 µM -0.942613503727098 0.161137397323391 no 2844 0.172939315089505 892 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_628 1636-0253 16 µM -0.943260194404372 0.160970964900862 no 2845 0.172773915449396 904 4456143 SGTC_1379 2144-0755 36.5 µM -0.944063890258227 0.16076428202203 no 2846 0.172568500239442 919 5392327 SGTC_844 0330-0132 15.3 µM -0.94417492975418 0.160735740120185 no 2847 0.172540132099172 911 2828079 SGTC_2078 5212016 200 µM -0.948180114644223 0.159708448611849 no 2848 0.171518884323358 903 1899708 SGTC_3337 9144342 33.5465 µM -0.950618385177257 0.159085164004896 no 2849 0.170899066102101 900 17682949 SGTC_1737 st035557 69.7 µM -0.952483501085898 0.158609469601487 no 2850 0.170425914743685 905 5716916 SGTC_1529 apigenin 74 µM -0.953662309419179 0.158309298239174 no 2851 0.170127302227559 912 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2030 5175110 200 µM -0.954300185221914 0.158147025273738 no 2852 0.169965857158847 939 2831986 SGTC_1018 4259-0013 28.1 µM -0.954326060496131 0.158140445015917 no 2853 0.169959310253003 926 6801262 SGTC_1743 st037606 46.3785 µM -0.955397925774049 0.157868020308758 no 2854 0.169688251280002 908 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2638 epoxomicin 18 µM -0.956304204197928 0.157637921658364 no 2855 0.169459283245936 895 9915668 A protesome inhibitor. SGTC_2465 5809242 33.21 µM -0.956314290207428 0.157635362121459 no 2856 0.169456736167365 951 2731748 SGTC_177 1327-0068 8.361 µM -0.960607177525551 0.156548430677127 no 2857 0.168374859209951 913 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_507 nimesulide 162 µM -0.96066340307468 0.156534227545033 no 2858 0.168360718997987 918 4495 A COX2 inhibitor. SGTC_795 0685-0265 78 µM -0.961422635310038 0.156342521023733 no 2859 0.168169853815374 907 302754 SGTC_2107 5363541 170.161 µM -0.964971343692689 0.155448521790701 no 2860 0.167279582567679 907 244052 SGTC_2605 digitonin 300 nM -0.965692371463278 0.155267291818739 no 2861 0.167099068931611 912 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_988 1497-1057 103 µM -0.966404568934088 0.155088418297708 no 2862 0.166920889361682 915 3533044 SGTC_2529 gangaleoidin 93.61 µM -0.967369120022691 0.154846381349219 no 2863 0.166679770701263 925 4565183 SGTC_2368 9071271 200 µM -0.96922836793385 0.154380540541087 no 2864 0.166215630081981 932 27209959 SGTC_74 000s-0487 160.283 µM -0.969241045586994 0.154377367296442 no 2865 0.166212468114808 922 677548 SGTC_5 0352-0601 109.883 µM -0.97012163990483 0.154157058120597 no 2866 0.16599293182411 912 762456 SGTC_224 benfluorex 43.875 µM -0.970514833628413 0.154058755173896 no 2867 0.165894967325705 933 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2384 9036245 200 µM -0.972463061765528 0.15357228771245 no 2868 0.165410116309332 894 6462766 SGTC_2944 9067346 25.62 µM -0.97330691615106 0.153361895544607 no 2869 0.165200393057105 925 6473075 SGTC_2168 5727979 200 µM -0.97398097981729 0.153193973327166 no 2870 0.165032991616493 920 695210 SGTC_2093 5331342 194.4 µM -0.974552976070507 0.153051573667387 no 2871 0.164891024446309 906 33839 SGTC_114 0364-0001 490.298 µM -0.975374355414728 0.152847243077169 no 2872 0.164687299772349 929 4003655 SGTC_664 1222-0054 14.9 µM -0.978572489823829 0.152053382651098 no 2873 0.163895628825157 913 6813991 SGTC_2742 clothiapine 36.27 µM -0.979446486213972 0.151836911228871 no 2874 0.163679708835236 907 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3319 9138450 16.7555 µM -0.979760856244034 0.151759098157699 no 2875 0.163602089192587 902 2029690 SGTC_3260 9137109 49.47 µM -0.981661333196483 0.151289255296597 no 2876 0.163133360323659 907 17478346 SGTC_3058 9093861 49.47 µM -0.983388700313592 0.150863049489798 no 2877 0.162708084740895 903 17217477 SGTC_1878 temozolomide 1 mM -0.984643117246261 0.150554039556553 no 2878 0.162399701296354 894 5394 DNA alkylating agent. SGTC_3286 9117135 37.221 µM -0.984963072376854 0.150475290135001 no 2879 0.162321105071537 910 3438150 SGTC_2914 7968218 45.32 µM -0.98924393047291 0.149424297558381 no 2880 0.16127190476078 905 2977111 SGTC_317 4495-0002 170 µM -0.996344904726443 0.147691768352786 no 2881 0.159541296310125 920 15991618 SGTC_1935 st074532 41.6 µM -0.997810571470228 0.147335849821499 no 2882 0.15918561149373 906 2829742 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.998291302151782 0.147219235781864 no 2883 0.159069062022314 921 2724278 An inhibitor of dopamine biosynthesis. SGTC_1897 st060201 15 µM -0.999995495887906 0.146806336707026 no 2884 0.158656343797178 930 611878 SGTC_573 3702-0553 84.7 µM -1.00342927561417 0.145976748107317 no 2885 0.157826892403276 923 1222756 SGTC_1486 3970-0793 4.53 µM -1.00819184242536 0.144831352951029 no 2886 0.156681186671868 934 2844330 SGTC_1478 0453-0656 35.7 µM -1.00871881296551 0.144704989650176 no 2887 0.156554753353843 957 5258496 SGTC_2302 7771753 200 µM -1.00885189213476 0.144673090082493 no 2888 0.156522834983025 918 2203047 SGTC_2203 7227154 166.4 µM -1.01007563390717 0.144379976713338 no 2889 0.156229527527794 935 896304 SGTC_1413 3910-0535 34.4 µM -1.01161433504664 0.144011991937613 no 2890 0.155861244551042 927 2876951 SGTC_1361 1608-0041 5.61 µM -1.01171920884284 0.143986934114924 no 2891 0.155836164209737 926 X1361 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.01191543021222 0.143940058230634 no 2892 0.155789245441067 930 551469 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.01256769396167 0.143784311062625 no 2893 0.155633348682974 943 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_56 0957-0365 83.25 µM -1.01472732021242 0.143269448435024 no 2894 0.15511791363806 929 6752360 SGTC_735 3076-0345 636 µM -1.01531269296653 0.143130108223869 no 2895 0.154978397889031 927 2888990 SGTC_2794 7785382 27.27 µM -1.01550246222397 0.143084955828496 no 2896 0.154933186723013 914 2205081 SGTC_3177 9107506 49.47 µM -1.01794359508128 0.142504987508212 no 2897 0.154352381118565 934 8897194 SGTC_1283 0922-0125 16.4 µM -1.01898060985487 0.142259093679709 no 2898 0.154106086022138 916 3360884 SGTC_1162 k048-0130 20.1 µM -1.02249113840651 0.141428819591301 no 2899 0.153274252343312 922 6797406 SGTC_1097 itavastatin 7.23 µM -1.03021798713741 0.139612933085704 no 2900 0.151453843950725 926 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_572 0960-0087 17.7 µM -1.03045036083062 0.13955856963837 no 2901 0.151399321419441 949 6796365 SGTC_3253 9135987 49.47 µM -1.03252465089163 0.139073930686473 no 2902 0.150913202892996 934 4182430 SGTC_620 0109-0052 432 µM -1.03275039384987 0.139021257108638 no 2903 0.150860361843582 948 493037 SGTC_1245 0418-0076 17.2 µM -1.03302951182503 0.13895614808756 no 2904 0.150795044004719 972 6790114 SGTC_993 3909-8757 62.7 µM -1.0334114034494 0.138867099002326 no 2905 0.150705706081246 932 4288324 YLR208W SEC13 SGTC_2419 paclitaxel 166.5 µM -1.03476307189863 0.138552230604356 no 2906 0.150389786320018 945 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_83 0170-0301 39.027 µM -1.03793865784127 0.137814399446969 no 2907 0.149649307238999 936 3089716 SGTC_521 r062-0005 13.8 µM -1.03907608955286 0.137550776269659 no 2908 0.149384675074386 940 2832033 SGTC_2583 asiatic acid 100 µM -1.03973777296198 0.137397576014866 no 2909 0.149230873192724 951 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3300 9124615 50.48 µM -1.03982244484271 0.137377980257127 no 2910 0.14921119967036 950 24824903 SGTC_1787 fluconazole 80 µM -1.04076164888874 0.137160746649544 no 2911 0.148993091648005 905 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2591 skatole 100 µM -1.04150216539387 0.136989634094316 no 2912 0.148821274371313 946 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3257 9139206 32.98 µM -1.04374789012772 0.136471602456144 no 2913 0.148301023271008 940 4910041 SGTC_1976 st070609 63.5 µM -1.04446540251785 0.136306373387261 no 2914 0.148135059031542 916 682556 SGTC_2468 5987765 72.9 µM -1.04551552518146 0.136064797519634 no 2915 0.147892384493724 929 26772094 SGTC_3129 9127257 49.47 µM -1.04647608201181 0.135844082645512 no 2916 0.147670641060404 948 837894 SGTC_579 4491-1009 110 µM -1.04697632979685 0.135729233828923 no 2917 0.147555247662895 969 1271041 SGTC_363 0455-0021 3.06 µM -1.04719293744309 0.135679524848946 no 2918 0.147505300985355 915 4597466 SGTC_278 4092-0821 23.9 µM -1.04763077125578 0.135579085074596 no 2919 0.147404377255002 947 877900 SGTC_2487 5918373 44.05 µM -1.04822138276761 0.135443678576174 no 2920 0.147268310529018 940 2876279 SGTC_615 k087-0205 167 µM -1.04852942414778 0.13537309228085 no 2921 0.147197376512575 940 9642773 SGTC_919 tnp00227 403.569 nM -1.04906502627902 0.135250421503513 no 2922 0.147074095642197 956 1269246 A methoxyflavone. YNL221C POP1 SGTC_899 1083-0020 478 µM -1.04924239546026 0.135209814838626 no 2923 0.147033285401701 947 767123 SGTC_1376 2910-0861 41.3 µM -1.0519468915645 0.134591686385171 no 2924 0.146411958200781 946 1112859 SGTC_1017 4239-0030 168 µM -1.05295013299997 0.134362883639114 no 2925 0.146181923767387 917 1149593 SGTC_2136 5328288 199.296 µM -1.05517633217753 0.133856123203974 no 2926 0.145672343263319 956 262395 SGTC_3062 9077494 49.47 µM -1.06057074014242 0.132633621554194 no 2927 0.14444251288399 842 16459633 SGTC_603 3794-0023 45.9 µM -1.06131632485471 0.132465261174338 no 2928 0.144273084616027 961 3802260 SGTC_2132 5317594 122.667 µM -1.06339515537652 0.131996618679013 no 2929 0.143801394424535 945 794577 SGTC_245 methotrexate 289.6 µM -1.064689587787 0.13170538582121 no 2930 0.143508211720849 925 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_359 0081-0058 15.9 µM -1.06701899827856 0.131182412016899 no 2931 0.142981628534847 926 3494159 SGTC_1866 st057638 64 µM -1.06758514930371 0.131055522933805 no 2932 0.142853842727546 918 688802 SGTC_950 1165-0508 94.1 µM -1.06836047611297 0.13088188976205 no 2933 0.142678969178509 950 6148369 SGTC_2060 5238662 140 µM -1.07457767806045 0.12949530601064 no 2934 0.141281925044838 965 790130 SGTC_1068 loratadine 26.9 µM -1.07508796691121 0.129381953122573 no 2935 0.141167673150559 971 3957 A H1 histamine antagonist. SGTC_822 1487-0950 154 µM -1.07557759288743 0.129273254833842 no 2936 0.141058106509269 932 1958375 SGTC_1137 ixabepilone 100 µM -1.07838574918106 0.128651059163304 no 2937 0.140430822010868 941 154225 A novel microtubule stabilizer. SGTC_7 0192-1582 4.227 µM -1.08445504664448 0.127313408630938 no 2938 0.139081544128181 971 252616 SGTC_3118 9124250 49.47 µM -1.08655320819439 0.126853239969809 no 2939 0.138617156930484 928 1504786 SGTC_311 1315-0136 58 µM -1.08732171191149 0.126684981868649 no 2940 0.138447328218927 961 6759207 SGTC_2287 7945887 168.79 µM -1.0886208570341 0.126400897393878 no 2941 0.138160557659669 928 1245853 SGTC_3340 9146634 11.102 µM -1.0889418884453 0.12633076579969 no 2942 0.138089756314413 934 4907387 SGTC_2808 7946468 45.46 µM -1.09005087066796 0.126088709385544 no 2943 0.13784536803905 963 2970879 SGTC_2438 5259590 200 µM -1.09096660921956 0.125889075943842 no 2944 0.137643787758359 955 1201127 SGTC_380 3970-0968 6 µM -1.09167904571633 0.125733915423893 no 2945 0.137487099299604 936 2891601 SGTC_1107 amlodipine 47 µM -1.09599428197077 0.124796957590107 no 2946 0.136540638409197 862 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_877 0771-0151 33.1 µM -1.09623935095703 0.124743893095102 no 2947 0.136487021463074 959 6166523 SGTC_2863 9028737 58.44 µM -1.09656788859706 0.124672779973961 no 2948 0.136415165584113 941 6460917 SGTC_1495 4469-0029 237 µM -1.09665761538702 0.124653363223418 no 2949 0.136395545552036 941 793680 SGTC_891 0929-0073 133 µM -1.10200109526654 0.123500850918131 no 2950 0.135230597724599 963 5603632 SGTC_1630 st005209 31.3 µM -1.10375877470433 0.123123381015722 no 2951 0.134848896130545 928 3367314 SGTC_2021 4019055 173 µM -1.10589180914027 0.12266638891268 no 2952 0.134386675233707 952 44827708 YER133W GLC7 SGTC_200 k038-0079 37.545 µM -1.10716450560264 0.122394287416102 no 2953 0.134111405262995 982 3436683 SGTC_680 0417-1641 114 µM -1.10786310355073 0.122245107936172 no 2954 0.133960471142587 960 2835990 SGTC_1913 st060213 96.1 µM -1.11315380531282 0.121119468171996 no 2955 0.132821189278138 965 688959 SGTC_853 0419-0306 21 µM -1.11463177648275 0.12080632480127 no 2956 0.132504123736304 954 762713 SGTC_190 3970-0790 3.722 µM -1.11616043144433 0.120483042788145 no 2957 0.132176734177277 951 2832352 SGTC_2861 9024595 19.48 µM -1.11948014043157 0.119783085655797 no 2958 0.131467679325046 948 16482810 SGTC_1510 1123-0200 71.5 µM -1.12070564895623 0.119525414538369 no 2959 0.131206588432142 964 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1944 st076371 56.9 µM -1.12177660250862 0.119300559976926 no 2960 0.130978718418875 952 24208455 SGTC_221 trifluoperazine 10.304 µM -1.12445184889361 0.118740177106564 no 2961 0.130410693366307 969 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2935 9038016 29.96 µM -1.12516715547893 0.118590657680791 no 2962 0.130259104124587 952 6463195 SGTC_386 1509-0011 3.07 µM -1.12684941477882 0.118239542135984 no 2963 0.129903076914915 959 3107280 SGTC_3233 9132340 49.47 µM -1.13312799931846 0.116935590129316 no 2964 0.128580252385067 981 17682950 SGTC_3065 9113888 49.47 µM -1.13349185831254 0.116860336653102 no 2965 0.128503879159452 972 16648368 SGTC_1613 st002381 52.1 µM -1.13467279940014 0.116616330430823 no 2966 0.128256219106754 953 551167 SGTC_2820 7989630 71.43 µM -1.13623871683699 0.116293337810281 no 2967 0.127928335476419 922 2984098 SGTC_274 sirtinol 40.1 µM -1.13702307452903 0.116131791756 no 2968 0.127764319845474 950 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1060 3448-7350 82 µM -1.13764046770823 0.116004745730655 no 2969 0.127635320702974 970 570178 SGTC_2463 5473429 200 µM -1.13769782242482 0.115992948393948 no 2970 0.127623341512618 944 5399405 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.14127208727373 0.115259434782585 no 2971 0.126878356991011 960 6708760 SGTC_142 0335-0849 62.6745 µM -1.14402903507095 0.114695908571925 no 2972 0.1263057979335 925 3889043 YPR107C YTH1 SGTC_2206 7254556 146.969 µM -1.14644773189223 0.114203138405372 no 2973 0.125804971182073 951 4398905 SGTC_865 0488-0499 301 µM -1.1468682694994 0.114117614801748 no 2974 0.125718034236387 942 9634651 SGTC_2699 st077704 54.6 µM -1.14760796756004 0.113967295104779 no 2975 0.125565219563255 963 645852 SGTC_798 1287-0182 476 µM -1.14886312040983 0.113712548792623 no 2976 0.125306213442863 986 1649755 SGTC_1616 st002734 56.1 µM -1.14969363637427 0.113544210244784 no 2977 0.125135038133543 955 4026101 SGTC_61 0978-8327 98.565 µM -1.15034681531274 0.113411941293289 no 2978 0.125000528028108 951 6150059 YHR072W ERG7 SGTC_1851 st056236 18.9 µM -1.15653071032516 0.112165143209425 no 2979 0.123732072758085 931 5393171 SGTC_2798 7813637 45.45 µM -1.15663913135486 0.112143371080814 no 2980 0.123709913858599 957 956368 SGTC_3136 9095672 49.47 µM -1.15790970186969 0.111888451728952 no 2981 0.123450443945309 912 17217380 SGTC_2736 butenafine 14.65 µM -1.15981975785361 0.111506010158366 no 2982 0.123061099031195 957 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1124 fisetin 1.16336 µM -1.16067910349636 0.111334252848886 no 2983 0.122886211458476 962 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.16273807983805 0.110923496174722 no 2984 0.122467893286757 977 364106 SGTC_1477 0139-0234 16 µM -1.16388467784144 0.110695226091091 no 2985 0.12223537488175 966 620880 SGTC_3197 9113331 49.47 µM -1.16406227778299 0.110659898797515 no 2986 0.122199387159193 955 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.16408709113372 0.110654963693074 no 2987 0.122194359731926 967 97141 SGTC_1512 0259-0544 12.2 µM -1.16493110424271 0.110487192625936 no 2988 0.122023440898667 948 18476 SGTC_1882 5615643 20 µM -1.16504231103105 0.110465100789159 no 2989 0.122000933234548 923 2253075 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.16578611380913 0.110317421721712 no 2990 0.121850466466686 949 2346 DNA damaging agent; causes G2/M arrest. SGTC_2911 7942208 15.64 µM -1.16614271385353 0.110246670440166 no 2991 0.121778374703843 936 1243384 SGTC_2017 5132927 60.65 µM -1.1720349584843 0.109082327342848 no 2992 0.120591510553931 981 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2216 7189485 200 µM -1.17369461798069 0.10875596956646 no 2993 0.120258683385404 956 731273 SGTC_29 0299-0004 12.984 µM -1.17392616271628 0.108710494154422 no 2994 0.120212301028465 972 16871 A napthoquinone isolated from Swertia calycina. SGTC_744 1594-0068 283 µM -1.1739927238855 0.10869742406421 no 2995 0.120198970024569 985 668392 SGTC_295 k015-0027 31 µM -1.17462332340163 0.108573654293211 no 2996 0.12007272397392 973 3887424 SGTC_160 3453-0671 289.699 µM -1.17890854481333 0.107735264796788 no 2997 0.119217297426506 999 5322268 SGTC_656 4090-1979 187 µM -1.18535576790878 0.10648268965367 no 2998 0.117938406232482 958 22330961 SGTC_2706 st078239 82.5 µM -1.18738642307282 0.106090357137987 no 2999 0.117537616428786 975 15434492 SGTC_1177 0983-0204 23.6 µM -1.18752388850011 0.106063835936857 no 3000 0.117510519807583 953 766818 SGTC_36 0335-0881 14.2 µM -1.18876535790398 0.105824536235357 no 3001 0.117266006770092 937 23828853 SGTC_2745 rifampicin 24.3 µM -1.19457622589834 0.104709648821155 no 3002 0.116126321237211 944 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_143 4032-1194 15.74 µM -1.19520607873063 0.104589316620963 no 3003 0.116003262074979 969 1806963 SGTC_1222 0366-0074 1.18 µM -1.19593688923015 0.104449822229527 no 3004 0.115860594099433 980 286520 SGTC_3322 9139058 2.11 µM -1.19827535140866 0.104004371152417 no 3005 0.115404919554497 973 4908926 YPR165W RHO1 SGTC_1949 st076024 69.1 µM -1.19876187075584 0.103911867989754 no 3006 0.115310276290325 978 2921930 SGTC_2788 5282734 71.43 µM -1.19992876616226 0.103690246408759 no 3007 0.115083503430855 963 743706 SGTC_1325 1431-0015 227 µM -1.20055300686708 0.103571828938147 no 3008 0.114962319628593 967 1103340 SGTC_2427 5545055 42.75 µM -1.20104886459033 0.103477835477631 no 3009 0.114866123504671 958 5372858 SGTC_3201 9113999 49.47 µM -1.20153265996455 0.10338618820935 no 3010 0.114772322669461 974 16649224 SGTC_777 1315-0167 517 µM -1.20195983608723 0.103305315543966 no 3011 0.114689544792325 949 4221767 SGTC_2738 aclarubicin 5.55 µM -1.20256146946781 0.103191492670549 no 3012 0.114573032778304 976 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1617 st002906 78 µM -1.20495506230224 0.102739551326297 no 3013 0.114110325147915 981 5150859 SGTC_225 nsc-122657 1.016 µM -1.20723964398075 0.102309536025991 no 3014 0.113669933532214 980 275685 SGTC_3091 9116372 49.47 µM -1.20858964846131 0.102056047580483 no 3015 0.113410267634538 986 17169793 SGTC_127 0180-0333 59.125 µM -1.20890431798712 0.101997028253968 no 3016 0.113349803534709 911 771601 SGTC_831 k061-1017 217 µM -1.20979189091413 0.101830689166434 no 3017 0.113179379312678 1011 1240153 SGTC_3084 9116877 49.47 µM -1.21184743112943 0.10144622094335 no 3018 0.11278539409344 959 27241325 SGTC_2666 tannic acid 100 µM -1.21263233861749 0.101299691153367 no 3019 0.112635209588549 957 16134267 A thiamine antagonist. SGTC_2843 9000894 45.46 µM -1.21727344789646 0.100436420310659 no 3020 0.111750096595096 936 2242070 SGTC_2053 5265679 138 µM -1.21792798785354 0.100315105636711 no 3021 0.111625669700108 962 764595 SGTC_660 4031-1742 102 µM -1.21845770570496 0.100217004243424 no 3022 0.111525043860919 945 6738706 SGTC_2164 5685496 200 µM -1.21855631655572 0.100198749686175 no 3023 0.111506318794008 994 759046 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.22275700148321 0.0994233834382677 no 3024 0.110710745199987 980 16486 A toxic proline analog. SGTC_2305 7443522 69.23 µM -1.22851715373428 0.0983673125572053 no 3025 0.1096264470136 951 5415886 SGTC_187 1488-2104 32.728 µM -1.23094035824989 0.0979255036592589 no 3026 0.109172585866141 985 2852859 SGTC_192 3455-0609 60.9 µM -1.2329244326151 0.097564843079421 no 3027 0.108801979456928 984 3769639 SGTC_191 3914-0123 66.505 µM -1.24133080042399 0.0960475572973428 no 3028 0.107241785491817 1005 3144412 SGTC_1449 4112-4002 201 µM -1.24256495850072 0.0958262697195629 no 3029 0.107014094700312 988 2059539 SGTC_2755 lomerizine 42.69 µM -1.2427947912141 0.0957851016043283 no 3030 0.106971731225686 964 3949 A calcium channel blocker. SGTC_2537 larixol 68.93 µM -1.242977560532 0.0957523728708736 no 3031 0.10693805125752 971 6708759 SGTC_1194 1488-0194 225 µM -1.24506902237994 0.0953784377091124 no 3032 0.106553189906967 979 1391452 SGTC_772 k072-0172 35.3 µM -1.24541751420466 0.0953162350337969 no 3033 0.106489159323083 954 5861980 SGTC_2280 7785178 200 µM -1.24843209009919 0.0947794063661362 no 3034 0.105936431675766 976 2954328 SGTC_1849 st056239 19.2 µM -1.24893910341357 0.0946893379215787 no 3035 0.105843673960883 972 5393181 SGTC_2746 daunorubicin 9.88 µM -1.25012831398052 0.0944783279984819 no 3036 0.105626339115148 959 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_320 4092-0846 5.34 µM -1.25065769425573 0.0943845079625218 no 3037 0.105529695787086 971 1359356 SGTC_1706 st031321 9.9705 µM -1.25074548971176 0.0943689549547593 no 3038 0.105513674088316 977 6103185 SGTC_1335 1486-0900 202 µM -1.2532493513955 0.0939261898574923 no 3039 0.105057487305506 979 X1335 SGTC_81 0411-0046 9.971 µM -1.25501864055633 0.0936142470541043 no 3040 0.104735996597121 966 12925265 SGTC_2811 7967822 32.47 µM -1.25600795616795 0.0934401549508873 no 3041 0.104556542747124 973 2232244 SGTC_174 3553-0389 74.3 µM -1.25857114383202 0.0929902176288261 no 3042 0.104092637620115 989 738071 SGTC_1903 st060211 78.3 µM -1.2609994641381 0.0925654339488775 no 3043 0.103654520106539 966 688960 SGTC_2975 9084847 53.72 µM -1.26656122189406 0.0915979331233736 no 3044 0.102656112776695 987 27211724 SGTC_3334 9142812 21.919 µM -1.26706519747926 0.0915106352312284 no 3045 0.102565989232354 980 45283678 SGTC_2307 7538926 6.34 µM -1.2680077920278 0.0913475259599132 no 3046 0.102397583972177 975 96582 SGTC_1523 st012844 44.7 µM -1.26973667241347 0.0910489158846592 no 3047 0.102089222571479 995 4274103 SGTC_2461 5755302 26.15 µM -1.27011087727017 0.0909843791073725 no 3048 0.102022568797686 1019 2788904 SGTC_1520 flindersine 88 µM -1.27049953511541 0.0909173856444322 no 3049 0.101953374172176 971 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_695 3505-6186 243 µM -1.27208374136425 0.0906446925124269 no 3050 0.101671683633442 984 1819379 SGTC_1850 st056238 17 µM -1.27266172665173 0.0905453538479252 no 3051 0.101569052256674 967 5393177 SGTC_3131 9127911 49.47 µM -1.27365398444929 0.0903750024350167 no 3052 0.101393035538563 979 45595681 SGTC_84 0443-0269 128.823 µM -1.27424248191035 0.0902740813378786 no 3053 0.101288746940455 954 6150058 SGTC_1421 4029-0249 71.4 µM -1.27482759650419 0.0901738233730357 no 3054 0.101185135328548 985 2894095 SGTC_1961 st076550 68.7 µM -1.27527614099334 0.0900970223890053 no 3055 0.101105759752852 991 1579337 SGTC_574 1315-0397 40 µM -1.27613480515871 0.0899501352000291 no 3056 0.100953934964979 1004 6794277 SGTC_954 1189-0853 2.85 µM -1.27766795928548 0.0896883092141307 no 3057 0.100683263610265 969 2828194 SGTC_2353 9059630 146.67 µM -1.2817506409879 0.0889938490235481 no 3058 0.0999650670483356 1002 4779114 SGTC_1407 3909-7909 12.3 µM -1.28385268822705 0.0886378575456013 no 3059 0.0995967520466342 957 4411780 SGTC_2385 9074692 200 µM -1.28466449322374 0.0885006588729041 no 3060 0.0994547755424874 992 17046906 SGTC_973 1325-0077 65.9 µM -1.29215281969593 0.0872425511747573 no 3061 0.0981521134769347 1007 2835149 SGTC_3261 9137475 49.47 µM -1.29319679167022 0.0870682202324943 no 3062 0.0979715025136051 944 17027690 SGTC_299 1273-0059 1.44 µM -1.29477595492241 0.0868050133134104 no 3063 0.0976987645297407 951 2848077 SGTC_533 1222-0222 6.71 µM -1.29733688740845 0.0863794346397644 no 3064 0.0972576488062193 999 3982874 SGTC_2774 tamoxifen 10.92 µM -1.29759942267513 0.0863358945548506 no 3065 0.0972125103268257 980 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1337 1486-1011 40.3 µM -1.29815106938806 0.0862444603434463 no 3066 0.0971177141360356 988 X1337 SGTC_2150 5556613 200 µM -1.30509957203609 0.0850989559161121 no 3067 0.095929472240871 1003 743190 SGTC_2338 7999974 200 µM -1.30550402911844 0.0850326314796002 no 3068 0.0958606380414059 976 315925 SGTC_2506 ethyl hematommate 54.16 µM -1.30641052640403 0.0848841212886808 no 3069 0.0957064940274335 991 3940691 An allergen. SGTC_2925 9010536 32.5 µM -1.3091465849161 0.0844370558473917 no 3070 0.095242350896023 919 2994177 SGTC_2592 piperlongumine 83.33 µM -1.3096022244978 0.0843627773364985 no 3071 0.0951652177642375 1005 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2994 9053520 71.4286 µM -1.31689702074468 0.0831802447473371 no 3072 0.0939365726380057 994 4647384 SGTC_1189 1431-2119 7.28 µM -1.32269824536938 0.0822487609717608 no 3073 0.0929678736445091 997 3107275 SGTC_3073 9114972 49.47 µM -1.32490260186427 0.081896881834296 no 3074 0.0926017288953991 989 41905075 SGTC_1433 4060-0023 7.6 µM -1.32571175101753 0.0817680032386868 no 3075 0.0924675967868508 993 3840627 SGTC_1971 st069429 63.5 µM -1.32571486895774 0.0817675069193488 no 3076 0.092467080206186 975 1246522 YGL099W LSG1 SGTC_2265 7929201 200 µM -1.32636732021186 0.0816636985015851 no 3077 0.0923590289814218 991 1265108 SGTC_296 1222-0039 74.9 µM -1.32638558608219 0.0816607937361862 no 3078 0.0923560053501156 1006 5984176 SGTC_3209 9113616 49.47 µM -1.32708312750189 0.0815499241392196 no 3079 0.0922405930020689 997 16649353 SGTC_3293 9120939 62.045 µM -1.32992179108187 0.0810999079680511 no 3080 0.0917720204352926 999 934087 SGTC_987 1497-1013 404 µM -1.33260017329225 0.0806770220626228 no 3081 0.0913315241401932 1006 1676435 SGTC_800 3448-7362 155 µM -1.33275073941697 0.0806532989265005 no 3082 0.0913068081135252 1005 15991913 SGTC_2851 9015922 71.43 µM -1.3364767016628 0.0800679148508124 no 3083 0.0906967553532803 977 2996893 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.33701260754516 0.0799839838388526 no 3084 0.0906092607693564 958 88881 An O-methylated flavonoid and antioxidant. SGTC_1257 0669-0121 16 µM -1.33718266959521 0.0799573634447219 no 3085 0.0905815087171468 981 4307855 SGTC_864 0469-0573 172 µM -1.33777780516334 0.0798642575830254 no 3086 0.0904844395283365 1021 689425 SGTC_323 4013-0906 34.3 µM -1.33836424821954 0.0797725918474041 no 3087 0.090388863693503 981 2910086 SGTC_1281 0884-0031 11.8 µM -1.33872961978459 0.0797155216017394 no 3088 0.0903293550038688 1000 1548255 SGTC_819 1013-0258 27.7 µM -1.34024705703337 0.079478831662581 no 3089 0.0900825187420983 997 5753198 SGTC_1916 st067606 49.2 µM -1.34045715956899 0.0794461018195433 no 3090 0.0900483816254347 959 19590279 SGTC_2940 9060638 45.86 µM -1.34129455236317 0.0793157538344552 no 3091 0.0899124189084797 983 4027022 SGTC_1356 1502-0781 85.8 µM -1.3421337743803 0.0791852836026471 no 3092 0.0897763123176618 990 567702 SGTC_2065 5221596 34.26 µM -1.3463822721312 0.0785272804733069 no 3093 0.0890896325951846 983 788581 SGTC_1339 1486-1321 22.7 µM -1.34706775269742 0.0784215033705718 no 3094 0.0889792063866293 999 3469382 SGTC_531 3788-1495 174 µM -1.3500960447748 0.0779554974281727 no 3095 0.0884925884554701 979 2896655 SGTC_78 0336-0123 156.75 µM -1.35075474997374 0.0778544119810396 no 3096 0.0883870037851723 987 6765896 SGTC_3230 9131665 49.47 µM -1.35367081673175 0.0774081046297486 no 3097 0.0879207113217563 977 15943720 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.35571579252435 0.0770962797950554 no 3098 0.0875948063410777 1005 641818 YHR062C RPP1 SGTC_1701 st028638 40.4 µM -1.35728713831294 0.0768573249144068 no 3099 0.0873449962079749 1003 3490878 SGTC_382 3229-0966 23.2 µM -1.357345699832 0.0768484303473759 no 3100 0.0873356964781775 1012 5722370 SGTC_499 genistein 192 µM -1.35780955927145 0.0767780050934099 no 3101 0.0872620604412304 1023 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1415 3966-0071 78.1 µM -1.3581985733604 0.0767189810444344 no 3102 0.0872003415840333 997 2893185 SGTC_1342 1486-1464 234 µM -1.35963030135438 0.0765020460115667 no 3103 0.0869734721443986 989 3253938 SGTC_1451 4152-0210 104 µM -1.3599353916628 0.0764558791825236 no 3104 0.0869251850368186 1013 659563 SGTC_2741 miltefosine 3.04 µM -1.36292027010281 0.0760053193360124 no 3105 0.0864538198129947 982 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2304 7443016 91.4 µM -1.36403788289819 0.0758371396661993 no 3106 0.0862778215417813 1004 939854 SGTC_2174 5790901 200 µM -1.36486523802158 0.0757128209823898 no 3107 0.0861477048762199 1002 786020 SGTC_862 0452-0056 10.2 µM -1.3649061615323 0.0757066758323383 no 3108 0.0861412727206898 1025 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1989 st071868 50.2 µM -1.36699221277907 0.0753939335636728 no 3109 0.0858138731888189 990 16414057 SGTC_3160 9100216 49.47 µM -1.37033871899918 0.0748942812454057 no 3110 0.0852905959291781 1002 17191039 SGTC_3190 9110366 49.47 µM -1.37034713974784 0.0748930271738569 no 3111 0.0852892822387034 1008 17123768 SGTC_2850 9015429 58.44 µM -1.37249420929198 0.0745737943542609 no 3112 0.0849548201648989 1011 6457570 SGTC_948 3448-0295 75.3 µM -1.37334812238445 0.0744471210264788 no 3113 0.0848220745464909 982 678569 SGTC_3313 9133968 57.047 µM -1.37350319477171 0.0744241345226288 no 3114 0.0847979843621119 985 1494643 SGTC_2934 9036370 36.88 µM -1.37387757502588 0.0743686621709818 no 3115 0.0847398462839937 973 6462800 SGTC_2614 arthonioic acid 13.39 µM -1.3744593545016 0.0742825218943063 no 3116 0.0846495601889103 1010 6710684 SGTC_1439 4092-1168 46 µM -1.37474871734003 0.0742397062170409 no 3117 0.0846046809752983 1021 2886240 SGTC_2545 solidagenone 89.61 µM -1.37943249790625 0.073549287813276 no 3118 0.0838807226047795 963 6708572 An anti ulcer agent SGTC_3178 9107506 49.47 µM -1.38191536185005 0.0731852948434022 no 3119 0.0834988452721854 997 8897194 SGTC_1357 1503-1303 39.5 µM -1.38353445706324 0.0729486756345275 no 3120 0.0832505247746455 996 292895 SGTC_3125 9127534 49.47 µM -1.39110391426478 0.0718502151728203 no 3121 0.0820969590519169 997 1639235 SGTC_952 1185-0122 232 µM -1.39244725043846 0.0716566059299221 no 3122 0.0818935023160515 997 678600 SGTC_471 1-acyl-paf 4 µM -1.39601576447053 0.0711442352290113 no 3123 0.0813548739905183 1012 16759367 SGTC_882 0843-0131 351 µM -1.39742720417894 0.0709423574857391 no 3124 0.081142571600675 996 5425421 SGTC_2946 9065502 71.43 µM -1.39822179593684 0.070828901041598 no 3125 0.0810232367639281 952 16489101 SGTC_2974 9094440 9.66 µM -1.40002842087624 0.0705714594450202 no 3126 0.0807524039326595 991 25236134 SGTC_2644 guaiazulene 100 µM -1.40353503194052 0.0700738256797106 no 3127 0.0802286765440162 990 3515 A coloring agent. SGTC_651 3253-0966 34.4 µM -1.40682282198463 0.0696097016978417 no 3128 0.0797399667249602 1021 781462 SGTC_1004 4084-0029 199 µM -1.40802677166598 0.0694403382894979 no 3129 0.0795615713885198 1014 716894 YLR208W SEC13 SGTC_2161 5662504 8.5105 µM -1.40884277164307 0.0693257295523387 no 3130 0.0794408323430133 961 2859334 SGTC_2834 9001755 58.44 µM -1.41225194859785 0.0688484797105792 no 3131 0.0789378946974213 998 2989575 SGTC_2549 cedrol 20.94 µM -1.41885710099195 0.067931038628917 no 3132 0.077970340661512 990 6708665 A sedative which affects the nervous system. SGTC_1832 st054113 55 µM -1.41958268494711 0.0678308348308913 no 3133 0.0778646046296508 1007 1251267 SGTC_3114 9122766 49.47 µM -1.42075947820492 0.0676685613858423 no 3134 0.0776933473448852 981 17176985 SGTC_3111 9122088 49.47 µM -1.42137241169753 0.0675841600321683 no 3135 0.0776042612101323 1003 16876704 SGTC_469 w7 172 µM -1.42611778367722 0.0669334692179124 no 3136 0.076917173138895 1019 45115570 A P450 inhibitor. SGTC_3128 9127691 49.47 µM -1.42698988691244 0.0668144143265807 no 3137 0.0767914048316267 1008 41316314 SGTC_3328 9140624 29.0385 µM -1.42738945831161 0.0667599217270902 no 3138 0.0767338338434439 1030 4904392 SGTC_231 b-estradiol 524 µM -1.43267118642313 0.0660428398535863 no 3139 0.075975913769301 1015 450 A steroid. SGTC_1073 triclabendazole 3.09 µM -1.4341789794223 0.0658392308616008 no 3140 0.0757605970400887 1024 50248 An antihelmetic and likely tubulin inhibitor. SGTC_638 3970-0837 4.09 µM -1.43464316998231 0.0657766456502435 no 3141 0.0756944030901395 1002 4118451 YLR208W SEC13 SGTC_2159 5658611 73.75 µM -1.43470188866743 0.0657687320992438 no 3142 0.0756860328981228 1007 793844 SGTC_1343 1487-0095 224 µM -1.43489267162666 0.0657430252641912 no 3143 0.07565884216303 1014 4560101 YGL055W OLE1 SGTC_1217 1183-1422 255 µM -1.43630086474982 0.0655535207212761 no 3144 0.0754583740488291 1006 2849664 SGTC_563 tetrahydrosecaminediol 614 µM -1.43792760385776 0.0653351334197819 no 3145 0.0752272982787367 1022 334274 A psychoactive constituent of the cannabis plant. SGTC_1219 1469-0211 33.1 µM -1.43807249266976 0.0653157097176264 no 3146 0.0752067432414816 1004 6822282 SGTC_2388 9080168 200 µM -1.43890546011325 0.0652041295245409 no 3147 0.0750886551613194 1014 15943073 SGTC_2636 apigenin dimethyl ether 100 µM -1.44076072205102 0.0649561394287396 no 3148 0.074826146749374 1018 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1164 k060-0068 93.7 µM -1.4452201206831 0.064363053375291 no 3149 0.074198033247564 1009 5963676 SGTC_1200 1643-0193 18.4 µM -1.44527312815128 0.0643560289401789 no 3150 0.0741905913536336 1014 5403974 SGTC_1253 0550-0034 176 µM -1.44785287211982 0.0640148863119746 no 3151 0.0738291011474532 1006 5969915 SGTC_2941 9056145 11.23 µM -1.45099326722115 0.063601503335002 no 3152 0.0733908675038062 1001 2119517 SGTC_2686 alizarin 95.37 µM -1.4523732921685 0.0634205032899491 no 3153 0.0731989191705536 992 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_252 miconazole 1.30953 nM -1.45332586352311 0.0632958008758073 no 3154 0.0730666497935435 984 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3140 9094243 49.47 µM -1.45361158376871 0.0632584340895715 no 3155 0.0730270117649625 1018 19291112 SGTC_189 3970-0742 2.116 µM -1.45656505597464 0.0628731816568105 no 3156 0.0726182397255876 1009 2891807 SGTC_640 3381-0960 37.1 µM -1.4603878696156 0.062377249092347 no 3157 0.0720917523556466 1027 1745025 SGTC_260 nsc-65238 3.989 µM -1.46145925066465 0.062238807804798 no 3158 0.0719447253190897 1018 3246252 SGTC_2825 7998094 58.44 µM -1.47264825153986 0.0608072748644482 no 3159 0.0704229534579846 1018 2987815 SGTC_2050 5263056 171 µM -1.47513454119372 0.0604926999623689 no 3160 0.070088187845098 1014 763468 YGL055W OLE1 SGTC_369 0957-0393 4.5 µM -1.47996235978701 0.0598855039705223 no 3161 0.0694416460064912 1016 6997992 SGTC_3025 9087895 49.47 µM -1.50025845003139 0.0573849327819811 no 3162 0.0667737339302106 1022 17173641 SGTC_2441 5730946 39.09 µM -1.50103625749847 0.0572907632073999 no 3163 0.066673091969004 1002 1774275 SGTC_1260 0700-1617 7.75 µM -1.50395080783602 0.0569389781882216 no 3164 0.066297016690261 994 2853078 SGTC_2460 5552655 174.22 µM -1.50617526695383 0.0566716331263466 no 3165 0.0660110934379297 1022 5401989 SGTC_518 1021-0119 62.6 µM -1.50881064417739 0.0563561830361377 no 3166 0.0656735899182018 1011 1097762 SGTC_1366 1683-0113 21.9 µM -1.51229451843267 0.0559412954509004 no 3167 0.065229477462114 1034 708623 SGTC_301 4119-0100 24.5 µM -1.51239351064895 0.0559295419649974 no 3168 0.0652168924010368 1031 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1703 st026983 48.3 µM -1.51962117386214 0.0550766422553753 no 3169 0.0643031065753163 1004 1104023 SGTC_258 haloperidol 50.781 µM -1.52684502170066 0.0542344935485708 no 3170 0.0633997766668064 1021 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2801 7907800 81.82 µM -1.54200496549597 0.0525003065340008 no 3171 0.0615361934797846 1005 6620925 SGTC_1431 4049-0260 9.09 µM -1.54208638417165 0.0524911130911056 no 3172 0.0615263016047844 1034 3854841 SGTC_957 1187-1561 14.1 µM -1.54369733512546 0.0523094741642286 no 3173 0.0613308361017196 1015 1538454 SGTC_3054 9094397 49.47 µM -1.54422477789685 0.0522501121881149 no 3174 0.0612669441130864 1026 2598354 SGTC_2514 salinomycin 42.74 µM -1.54430267305639 0.0522413498756743 no 3175 0.061257512661153 1032 23682228 A polyether potassium ionophore. SGTC_3101 9120531 49.47 µM -1.55254850478055 0.0513203696341719 no 3176 0.0602655180943849 1025 24824904 SGTC_3016 9080866 49.47 µM -1.55391143578776 0.0511693947449912 no 3177 0.0601027717665008 1032 17066299 SGTC_1191 1487-1166 10.6 µM -1.55416462693123 0.0511413871637979 no 3178 0.0600725763820374 1050 3955771 SGTC_2665 lovastatin 100 µM -1.55615441722064 0.0509217043127705 no 3179 0.0598356888071045 1036 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_226 1,3-diallylurea 8.28947 mM -1.5611986611444 0.050368159780323 no 3180 0.0592384424059438 1022 74537 YKL182W FAS1 SGTC_2963 9082507 9 µM -1.5684679757322 0.0495788869607544 no 3181 0.0583859789973013 1041 16459611 SGTC_3055 9094636 49.47 µM -1.56910450582438 0.0495102477075555 no 3182 0.0583117950301047 1023 25236176 SGTC_832 4083-0019 164 µM -1.57158731861199 0.0492432419674827 no 3183 0.0580231446823338 1041 1990758 SGTC_1515 3460-0031 42.1 µM -1.57400943885169 0.0489838724652584 no 3184 0.0577426336585582 1020 2876596 SGTC_2623 humulene 100 µM -1.57531104468697 0.0488449432607293 no 3185 0.0575923329258389 1037 6187145 An anti-inflammatory. SGTC_1231 0242-0792 125 µM -1.57857508239196 0.0484979350962871 no 3186 0.0572167768930982 1031 3707635 SGTC_1984 st072354 53.1 µM -1.58013181305632 0.0483331308188581 no 3187 0.0570383415816966 1011 5762938 SGTC_1338 1486-1223 76 µM -1.58910787870685 0.0473915937949349 no 3188 0.056018019673121 1022 3444526 SGTC_2386 9075165 157.42 µM -1.59323415815569 0.0469637302141454 no 3189 0.0555538355137641 1033 16452277 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.59981281606699 0.0462879857620653 no 3190 0.0548200574069746 1046 75037 A free radical scavenger. SGTC_21 0849-0113 22.993 µM -1.60356238428832 0.0459063454815975 no 3191 0.0544052738764765 1041 1560156 SGTC_1409 3909-8004 61.9 µM -1.61035881986564 0.0452210353009826 no 3192 0.053659772561707 1031 2119279 SGTC_1441 4106-0040 13 µM -1.61171222657592 0.0450855539122649 no 3193 0.0535122879206552 1041 2904180 SGTC_1736 st036774 51 µM -1.61345301197348 0.0449117748628615 no 3194 0.053323061936312 1021 1272247 SGTC_1741 st038134 10.228 µM -1.61346845052721 0.0449102360793245 no 3195 0.0533213861180321 1037 1272587 SGTC_1454 4239-0054 42.6 µM -1.62101390117156 0.0441632344796468 no 3196 0.0525073287130579 1028 1340767 SGTC_3149 9097855 49.47 µM -1.62398079202161 0.0438722689451635 no 3197 0.0521899540185973 1025 25236625 YMR079W SEC14 SGTC_2323 6148992 148.28 µM -1.62669516447903 0.0436074244319741 no 3198 0.0519009281295436 1014 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2497 7-hydroxyflavone 100 µM -1.62978142811219 0.0433078631793027 no 3199 0.0515738501521732 1033 5281894 SGTC_661 1304-0007 33.6 µM -1.64646809747957 0.041716871313431 no 3200 0.0498337115133943 1052 3117130 SGTC_482 fipronil 114 µM -1.6521622729201 0.0411849179408722 no 3201 0.0492507375185615 1053 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1069 diphenylcyclopropenone 8.49 µM -1.65258137614196 0.0411459833426312 no 3202 0.0492080454822893 1051 65057 A dermal irritant. YDR527W RBA50 SGTC_2328 6201408 200 µM -1.65264312741845 0.0411402491858919 no 3203 0.0492017576744994 1034 2890418 SGTC_1767 st044992 70.3 µM -1.65696467299944 0.0407405617823018 no 3204 0.0487633087899798 1040 9600693 SGTC_2840 9008771 71.43 µM -1.66356615886084 0.040136097722936 no 3205 0.0480995797036146 1036 2992978 SGTC_2606 farnesol 9.78 µM -1.66584799993411 0.0399288635517751 no 3206 0.0478718464724099 1023 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1638 st008370 60.6 µM -1.67160353037859 0.0394100142283533 no 3207 0.0473012640810811 1006 24207134 SGTC_2828 7998861 71.43 µM -1.67625044713925 0.0389951178498364 no 3208 0.0468445733051609 1017 2988188 SGTC_2833 9001315 45.46 µM -1.68560173091482 0.0381709750816084 no 3209 0.0459362678059703 1036 2989378 SGTC_2589 lobaric acid 100 µM -1.68608574415381 0.0381287078863318 no 3210 0.0458896426981386 1034 73157 A novel microtubule depolymerizer. SGTC_2752 diclazuril 33.15 µM -1.69262271149077 0.0375615876592676 no 3211 0.0452636526076347 1026 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1590 st077108 57.8 µM -1.69677077934009 0.0372053038745904 no 3212 0.0448700026012821 1044 5489485 SGTC_1677 st019204 53.9 µM -1.69745122545152 0.0371471238262031 no 3213 0.0448056924652679 1037 3945625 SGTC_2499 avocadenofuran 51.48 µM -1.69824068495717 0.037079716018612 no 3214 0.0447311723112047 1043 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_539 4859-0462 2.54 µM -1.70291093391935 0.0366829902416366 no 3215 0.0442923687673619 1024 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_858 0438-0351 2.77 µM -1.70773394575092 0.0362769386691267 no 3216 0.0438428602161697 1050 2799119 SGTC_1718 roemerine 11.9335 µM -1.71079096744511 0.0360214771008484 no 3217 0.0435598538024522 978 235224 An aporphine alkaloid with mutagenic activity. SGTC_149 3970-0822 46.1 µM -1.71287333398301 0.0358483081734488 no 3218 0.0433679225123359 1027 3114250 YBL034C STU1 SGTC_2715 st079500 56.4 µM -1.71436947540222 0.0357243110876837 no 3219 0.0432304454376395 1046 28246688 SGTC_3021 9087658 49.47 µM -1.72638817920705 0.0347409279872843 no 3220 0.042138800480535 1042 25237042 SGTC_2823 7987624 58.44 µM -1.72881519633087 0.0345450693427356 no 3221 0.0419210877553572 1042 2239440 SGTC_1862 st057513 3.81 µM -1.73019575797529 0.0344340642771598 no 3222 0.0417976530010533 1043 5393163 SGTC_2480 5767542 37.17 µM -1.73039407642329 0.0344181424389924 no 3223 0.041779945731194 1041 2867358 SGTC_765 1319-0117 244 µM -1.73232855766184 0.0342631512327166 no 3224 0.0416075400607405 1027 3487746 YGL099W LSG1 SGTC_430 0958-0115 16.4 µM -1.7417965304352 0.0335128282002463 no 3225 0.0407720270202657 1039 6833180 SGTC_2270 7924575 90.91 µM -1.7422238086647 0.0334792885573417 no 3226 0.0407346447266623 1030 1262135 SGTC_463 ikarugamyin 104 µM -1.74653309361658 0.03314256913594 no 3227 0.0403591808665205 1077 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_938 3126-1755 342 µM -1.746825121469 0.0331198519321863 no 3228 0.0403338387751358 1037 1777771 SGTC_1906 st060206 94.7 µM -1.76968410565193 0.0313810257494649 no 3229 0.0383898895664237 1028 5133468 SGTC_2871 9038510 12.99 µM -1.77593364216218 0.0309190016854654 no 3230 0.0378719275646602 1047 4945164 SGTC_1988 st071872 53.4 µM -1.78621865550521 0.0301709023559889 no 3231 0.0370319308200147 1060 16414116 SGTC_3041 9091929 49.47 µM -1.78837073984093 0.030016280059538 no 3232 0.0368581069001434 1039 25236887 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.78993636575609 0.0299042068215652 no 3233 0.0367320709175079 1059 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_254 nsc-64875 3.808 µM -1.79908699000248 0.0292560934618037 no 3234 0.0360024606498547 1053 56993 SGTC_986 1493-0483 84 µM -1.79976512099713 0.0292085312547125 no 3235 0.0359488667677467 1050 40079 SGTC_3152 9099253 49.47 µM -1.80217547294807 0.0290399955071317 no 3236 0.0357589011572942 1010 25236131 SGTC_1400 3771-8998 51.5 µM -1.80344428561117 0.0289516031900057 no 3237 0.0356592339490574 1075 670767 SGTC_2899 9053889 58.44 µM -1.80401521751384 0.0289119020106617 no 3238 0.0356144606959697 1043 6470052 SGTC_244 nsc-207895 1.295 µM -1.80423497189387 0.0288966329051517 no 3239 0.0355972395462918 1037 42640 SGTC_2639 lactacystin 53 µM -1.804671296479 0.0288663358050398 no 3240 0.0355630670077249 1028 3870 A proteasome inhibitor. SGTC_3100 9120536 49.47 µM -1.80613683254624 0.0287647665091169 no 3241 0.0354484843892362 1040 16421196 SGTC_2000 st075254 36.4 µM -1.81755581261293 0.0279835062981896 no 3242 0.0345660252479553 1042 17234175 SGTC_2352 9027995 87.8 µM -1.8195322173055 0.0278500958406168 no 3243 0.0344151361167972 1045 2997347 SGTC_998 3996-0085 177 µM -1.82687949105488 0.0273587809491061 no 3244 0.0338589452584029 1060 715391 SGTC_3306 9127676 59.7925 µM -1.83588980982995 0.026766146572903 no 3245 0.0331869775470419 1045 41905287 SGTC_1946 st076057 65.1 µM -1.8437553760389 0.0262576060255504 no 3246 0.0326093993543645 1057 953009 SGTC_2507 purpurin 79.67 µM -1.84552376763058 0.0261443914384654 no 3247 0.032480692173032 1055 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2748 diazoxide 86.69 µM -1.8553195567313 0.0255246219607236 no 3248 0.0317753035541106 1056 3019 A potassium channel activatior. SGTC_2299 7976368 114.88 µM -1.8571231895893 0.0254118597730419 no 3249 0.0316468148403814 1045 2979718 SGTC_484 loperamide 105 µM -1.85837463322876 0.0253338656073049 no 3250 0.0315579159915597 1068 3955 An opioid-receptor agonist. SGTC_1398 3558-0053 112 µM -1.86190007995774 0.0251152254559284 no 3251 0.03130858789476 1070 4532369 SGTC_3290 9121031 71.43 µM -1.86229517470509 0.0250908214313303 no 3252 0.0312807476312982 1044 17014854 SGTC_1402 3909-7673 35.9 µM -1.86312573734664 0.0250395844391875 no 3253 0.0312222889753295 1060 5328014 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.86556202062633 0.0248897970836752 no 3254 0.0310513337058204 1062 688664 SGTC_2281 7943571 200 µM -1.87124720292607 0.0245431817594545 no 3255 0.0306554124283618 1058 1244024 SGTC_2032 5185112 25.99 µM -1.87192232767878 0.0245022910131192 no 3256 0.0306086750498888 1047 5718189 SGTC_1828 st055811 49 µM -1.87535632248748 0.024295185985431 no 3257 0.0303718598547048 1058 5877589 SGTC_82 0054-0107 293.755 µM -1.88811571748306 0.0235384977133574 no 3258 0.0295052086279021 1058 3104697 SGTC_3034 9090421 49.47 µM -1.88986707284145 0.0234361985774512 no 3259 0.0293878701411446 1053 17173761 SGTC_2381 9035592 200 µM -1.89692171865021 0.023027907162022 no 3260 0.0289191352629535 1063 4749657 SGTC_910 3454-3003 490 µM -1.91092844063548 0.0222349992967646 no 3261 0.0280068887939148 1045 820824 SGTC_1054 3429-0080 167 µM -1.91195555113541 0.0221777732557113 no 3262 0.0279409477459233 1067 1162877 SGTC_742 0kpi-0133 140 µM -1.93014398904339 0.0211848032568967 no 3263 0.0267944996461071 1074 2728852 SGTC_544 k015-0020 52.4 µM -1.93231042214826 0.0210690759003528 no 3264 0.0266606014066474 1056 3008304 SGTC_1722 st034304 3.6505 µM -1.93434676075441 0.020960786119082 no 3265 0.026535253779839 1066 4036148 YLR033W RSC58 SGTC_3216 9129716 49.47 µM -1.93595371746538 0.0208756631778045 no 3266 0.0264366848631103 1037 8056934 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.94010650490097 0.0206570379595826 no 3267 0.0261833738207156 1054 23665772 A membrane-active detergent. SGTC_3314 9135860 59.4275 µM -1.95015546902376 0.0201360170664972 no 3268 0.0255787957951899 1049 25252478 SGTC_1403 3909-7815 62.9 µM -1.95117960867871 0.0200835485533266 no 3269 0.0255178418949977 1062 6615483 SGTC_2908 7930301 100 µM -1.95762640411008 0.0197559231845532 no 3270 0.0251369333724643 1051 2223178 SGTC_2708 st078559 56 µM -1.96453231763022 0.0194100095851379 no 3271 0.0247341961291877 1042 17250902 SGTC_2981 9013952 38.96 µM -1.96548119219333 0.0193628854344207 no 3272 0.0246792851994803 1048 2996344 SGTC_739 1486-1183 203 µM -1.97069803782952 0.0191055331404465 no 3273 0.0243792125612614 1062 4346692 SGTC_768 0384-0033 77.3 µM -1.97894150558526 0.0187048048176639 no 3274 0.023911296234549 1041 3965305 YMR134W ERG29 SGTC_624 k048-0052 28 µM -1.98013297533947 0.0186474814400317 no 3275 0.0238442943525975 1070 6835531 SGTC_2266 7929956 200 µM -1.9929922867419 0.0180382593877231 no 3276 0.0231311458517558 1060 2967153 SGTC_2664 lyso-paf C-16 73.48 µM -2.00046854323829 0.0176919270765271 no 3277 0.0227248466959005 1062 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2696 st077691 74.316 µM -2.00191845425904 0.0176254220172174 no 3278 0.0226467512699301 1061 757133 SGTC_2045 5106652 78.05 µM -2.0028702006414 0.0175818830518919 no 3279 0.0225956111838391 1053 673349 SGTC_557 1315-0110 16.2 µM -2.00913451006268 0.0172975979746873 no 3280 0.0222614353444571 1064 6833801 SGTC_618 k072-0232 33.2 µM -2.01073794755143 0.0172254655744872 no 3281 0.0221765717662721 1037 5872756 YGL099W LSG1 SGTC_2284 7945075 39.21 µM -2.0178338948781 0.0169093238898256 no 3282 0.0218042817753994 1054 1245402 SGTC_3155 9099265 49.47 µM -2.04649736684518 0.0156823001687805 no 3283 0.0203537306344802 1061 25236499 SGTC_2898 9056270 58.44 µM -2.0498020924416 0.0155458689882119 no 3284 0.0201918736740059 1041 19154699 SGTC_2458 5808907 16.39 µM -2.05837739449567 0.0151965911989045 no 3285 0.019776959997629 1075 2731747 SGTC_2608 thymoquinone 42.66 µM -2.06794416172527 0.0148149067074076 no 3286 0.0193226370368936 1064 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2478 5763493 32.33 µM -2.07840889499836 0.0144068658854533 no 3287 0.0188358570719204 1053 1365576 YLR208W SEC13 SGTC_136 0097-0015 404.482 µM -2.08326742437196 0.014220735118812 no 3288 0.0186134271506101 1062 4861337 SGTC_2383 9036125 200 µM -2.08976315991389 0.0139751216619654 no 3289 0.0183195401033285 1070 79580 SGTC_1341 1486-1360 280 µM -2.09268379442251 0.013865885347318 no 3290 0.0181886954170223 1074 3976547 SGTC_2980 9014342 25.29 µM -2.11077786143298 0.0132054152004248 no 3291 0.0173957049345669 1035 2996599 SGTC_375 3970-0961 9.27 µM -2.12026166271254 0.0128702238368938 no 3292 0.0169919924094907 1060 2898222 SGTC_1316 1272-0050 65.9 µM -2.13142933633622 0.0124849752782456 no 3293 0.0165268940956905 1072 7340392 SGTC_1359 1582-0056 520 nM -2.14209303326367 0.0121264724036278 no 3294 0.0160929982048924 1082 3661189 SGTC_2138 5575593 77.673 µM -2.16036769463748 0.0115328261667063 no 3295 0.015372108131104 1062 762213 SGTC_991 3996-0057 64.7 µM -2.17002438617436 0.0112294469486837 no 3296 0.0150024993020984 1073 715343 SGTC_3151 9099821 49.47 µM -2.17488346290757 0.0110794328319039 no 3297 0.0148194252320838 1064 17174189 SGTC_1027 k015-0025 8.67 µM -2.17754116225913 0.0109981214861756 no 3298 0.0147201070483282 1073 3598955 SGTC_3116 9124943 49.47 µM -2.17977068379833 0.010930310998656 no 3299 0.0146372320264657 1061 41905195 YPL160W CDC60 SGTC_2849 9019321 12.99 µM -2.20933403833324 0.0100649624436514 no 3300 0.0135757076541917 1060 16489627 SGTC_2508 celastrol 40.54 µM -2.21622500360629 0.00987206761313277 no 3301 0.0133380481431027 1060 122724 Celastrol is a natural product and antioxidant. SGTC_1488 4013-0813 75.9 µM -2.23544814610299 0.009350930531232 no 3302 0.0126939711382832 1078 2910057 SGTC_751 0833-0568 350 µM -2.23555710577366 0.00934804659215604 no 3303 0.0126903985037313 1080 6954252 SGTC_172 1112-0046 2.638 µM -2.23698929209837 0.0093102118258211 no 3304 0.0126435199472659 1078 2802135 YIL048W NEO1 SGTC_846 0335-0850 148 µM -2.23802380656498 0.0092829659590696 no 3305 0.012609751348248 1070 6819598 SGTC_599 1935-0052 86.5 µM -2.23803033335424 0.00928279428562294 no 3306 0.0126095385489849 1073 9557311 SGTC_2670 beta-carotene 100 µM -2.25810284114017 0.0087677938803942 no 3307 0.0119696242790883 1078 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1363 1636-0063 10.4 µM -2.27296372199651 0.00840281464108311 no 3308 0.0115141831048945 1078 6072185 SGTC_669 0108-0021 26.2 µM -2.27318134429326 0.00839757049871476 no 3309 0.0115076270234679 1067 17201 SGTC_2953 9074162 66.49 µM -2.27934852741319 0.00825014668688885 no 3310 0.011323177741314 1063 16451992 SGTC_734 2023-0417 80 µM -2.33124187951741 0.00709707749646905 no 3311 0.00987030449224319 1080 3935732 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -2.34976579480552 0.00672133036954957 no 3312 0.00939261339852665 1086 66535 A nucleotide analog. SGTC_1397 3532-0190 20.1 µM -2.36196451507977 0.00648359076119273 no 3313 0.00908919105917949 1087 5322280 SGTC_1273 0849-0096 14.1 µM -2.36607580342956 0.00640515909904724 no 3314 0.00898888152297854 1082 5286025 SGTC_2692 st077426 47.7 µM -2.37888513649022 0.00616614983801148 no 3315 0.00868254303815853 1075 25238571 SGTC_1220 1838-0075 193 µM -2.38622270869437 0.00603282680972985 no 3316 0.0085112195239097 1069 5529645 SGTC_3124 9127567 49.47 µM -2.39546315244801 0.00586856756002703 no 3317 0.00829969129177068 1074 17592030 SGTC_1872 amphotericin b 148 nM -2.40545361083188 0.00569545040731278 no 3318 0.00807620126164267 1083 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2948 9070189 9.45 µM -2.40626512775326 0.00568158935574538 no 3319 0.00805828180323162 1059 6473636 YDL196W YDL196W SGTC_2997 9067075 71.4286 µM -2.42941016265895 0.00529866406036402 no 3320 0.00756170619840485 1071 27209819 SGTC_1305 1181-0477 144 µM -2.45061547185793 0.00496816126788541 no 3321 0.00713061060331608 1082 6252086 SGTC_2622 2-methoxyxanthone 59.94 µM -2.46279235557186 0.00478678974621529 no 3322 0.00689298646562487 1088 71034 A hepatoprotective. SGTC_2393 9031399 185.94 µM -2.47261170077477 0.00464485809209893 no 3323 0.00670648949735267 1079 1526623 YDL150W RPC53 SGTC_1503 4585-0012 61.3 µM -2.48224681024749 0.00450925180085141 no 3324 0.00652784059782453 1080 2922052 SGTC_3119 9125183 49.47 µM -2.50488346200703 0.00420447181751427 no 3325 0.00612458727648155 1083 22695334 SGTC_2604 4'-hydroxychalcone 11.32 µM -2.50717788012196 0.00417463227212856 no 3326 0.00608497249539055 1080 5282362 SGTC_3297 9117502 71.43 µM -2.52020457291019 0.00400877993225955 no 3327 0.00586433234319655 1086 7453720 SGTC_3284 9108171 64.8615 µM -2.52315988413531 0.00397198482390225 no 3328 0.00581527538515982 1072 8687505 SGTC_3150 9097574 49.47 µM -2.56100144877209 0.00352686267108469 no 3329 0.00521854604748582 1082 17217476 SGTC_1131 3454-3128 32.3 µM -2.62377031807823 0.00288647884725361 no 3330 0.00434812033543513 1071 710982 SGTC_2103 5378138 10 µM -2.62765721888667 0.0028505081805973 no 3331 0.00429875511225717 1089 244142 SGTC_1297 1068-0111 14.1 µM -2.71763620836591 0.00212310954742474 no 3332 0.00328750431688005 1083 767057 SGTC_2099 5377090 177.372 µM -2.72373585172634 0.00208050288505543 no 3333 0.00322740546502357 1077 2243829 SGTC_633 0437-0093 97.7 µM -2.76403196299523 0.00181798006925633 no 3334 0.00285459732499985 1087 2831118 SGTC_2025 5147754 141 µM -2.78187828066401 0.00171164660978344 no 3335 0.00270226527882857 1079 315777 YLR208W SEC13 SGTC_481 bay k-8644 50 µM -2.7946628439435 0.00163898761510932 no 3336 0.00259769336917241 1089 2303 A calcium channel antagonist. SGTC_790 1575-0012 79.1 µM -2.80254559653936 0.00159559918956432 no 3337 0.0025350524452692 1081 378741 YLR208W SEC13 SGTC_2693 st077581 40.7 µM -2.81808437632211 0.00151312173372483 no 3338 0.00241555562053679 1065 25238761 SGTC_2976 9009005 19.48 µM -2.84841961779658 0.00136321358931629 no 3339 0.00219684754611257 1085 2993148 SGTC_824 1304-0008 100 µM -2.86225371623131 0.00129946316267825 no 3340 0.00210320016268472 1089 768245 SGTC_2839 9003951 25.97 µM -2.86506132380309 0.00128686265320779 no 3341 0.00208464246564902 1087 2990634 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.87845379044948 0.00122828106705195 no 3342 0.00199814911601451 1083 5024745 SGTC_1867 st057372 64 µM -2.90429133654059 0.00112210396324274 no 3343 0.001840427348806 1093 688837 SGTC_3264 9137442 49.47 µM -2.91245838588911 0.0010903340182632 no 3344 0.0017929798887504 1083 17015726 SGTC_2957 9076800 11.52 µM -2.94259546433456 0.000980103973508305 yes 3345 0.00162736709210886 1079 16459615 SGTC_2565 isoliquiritigenin 100 µM -3.07248083698832 0.000612503776667088 yes 3346 0.00106143731571086 1087 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2868 9035608 32.47 µM -3.16651341906806 0.000431076897783074 yes 3347 0.000771391138758031 1092 6462614 SGTC_3139 9095020 49.47 µM -3.23520101714838 0.000331582898934599 yes 3348 0.000607785591309308 1090 25236292 SGTC_3215 9129942 49.47 µM -3.34457592378985 0.00021612678615614 yes 3349 0.000412042352515134 1091 17682944 SGTC_3266 9136860 49.47 µM -3.35222880276777 0.000209652047251746 yes 3350 0.000400818688745518 1081 4871271 YPR165W RHO1 SGTC_2618 avocadyne 43.43 µM -3.36204147327385 0.000201614928723028 yes 3351 0.000386842511679812 1094 3015189 SGTC_1938 st074717 56.4 µM -3.48425502608849 0.000122861221449906 yes 3352 0.00024675450300403 1089 17250979 SGTC_1401 3807-4679 7.6 µM -3.65881272763744 5.89328285932352e-05 yes 3353 0.000126693204735531 1092 3291456 SGTC_1763 st044482 94.5 µM -3.96659586190258 1.49200090255144e-05 yes 3354 3.64532299926137e-05 1093 88505 SGTC_3144 9087057 49.47 µM -4.18814904793555 5.21585222160472e-06 yes 3355 1.40619399201056e-05 1090 17249618 SGTC_2624 nerol 100 µM -4.61130297209771 6.05907006442756e-07 yes 3356 2.0007641059292e-06 1095 637566 A natural product oil.