SGTCid condition conc unit APL5|YPL195W.score APL5|YPL195W.strain.pval APL5|YPL195W.strain.significant APL5|YPL195W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2779 methotrexate 400 µM 12.1846270774018 1.14773529553742e-27 yes 1 1.87683204674854e-34 4 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_528 3492-0019 172 µM 10.1033809479391 1.29601985676704e-19 yes 2 2.6684905298943e-24 39 2869262 SGTC_445 e6 berbamine 66 µM 9.80592637066158 1.39024330409834e-18 yes 3 5.3084154874767e-23 6 6610268 A calcium/calmodulin antagonist. SGTC_245 methotrexate 289.6 µM 7.70792709946846 3.62047794589631e-12 yes 4 6.39388780422188e-15 4 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_841 0251-0215 91.2 µM 7.59653598083927 7.20718311027125e-12 yes 5 1.5208137873012e-14 23 3888614 SGTC_1687 st020778 55.3625 µM 7.370539188368 2.82836800117737e-11 yes 6 8.49696502464522e-14 80 4259299 SGTC_1951 sophoraflavanone G 9.2 µM 7.04666617613849 1.87267634116285e-10 yes 7 9.16276225120531e-13 1 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3217 9129673 49.47 µM 6.44435610325337 5.07438748918746e-09 yes 8 5.80461092564403e-11 4 17248312 SGTC_459 nigericin 15.3 µM 6.21657302648975 1.6428003842542e-08 yes 9 2.54064978624283e-10 28 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1529 apigenin 74 µM 5.97104874753573 5.57299620440577e-08 yes 10 1.17866644173292e-09 5 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1173 0443-0020 122 µM 5.96779386242492 5.6622145485248e-08 yes 11 1.20241458175965e-09 9 5331295 SGTC_2291 7917025 104.35 µM 5.93667416005229 6.5880206701953e-08 yes 12 1.45430959538569e-09 21 2964612 SGTC_391 gliotoxin 8.33 µM 5.62626365524655 2.86486179037748e-07 yes 13 9.20774036108272e-09 29 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1873 rapamycin 2 nM 5.52102589288575 4.63701912225854e-07 yes 14 1.68513053025334e-08 39 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1953 st076800 12.1 µM 5.33095054394343 1.08303439086052e-06 yes 15 4.88500127099669e-08 19 297591 SGTC_1981 st071826 47 µM 5.18866890937466 2.00709231862471e-06 yes 16 1.05901296280148e-07 4 11838600 SGTC_1624 st003710 6.25 µM 4.83482908951019 8.70617382273041e-06 yes 17 6.66300389827303e-07 25 24207033 SGTC_2322 7413319 38.22 µM 4.78648623144697 1.0560465676989e-05 yes 18 8.4863288580109e-07 107 1840400 SGTC_2737 bleomycin 30.5 nM 4.77639998372796 1.09921244153518e-05 yes 19 8.92306253504542e-07 64 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_524 r073-0010 27.8 µM 4.71406051467122 1.40563502436747e-05 yes 20 1.21414247586005e-06 34 2772106 SGTC_1828 st055811 49 µM 4.56184909745211 2.53074574527727e-05 yes 21 2.53525425155506e-06 3 5877589 SGTC_1555 citronellol 128 µM 4.55996884206605 2.54891621300571e-05 yes 22 2.55806056122896e-06 1 8842 A terpine precursor. SGTC_679 0422-0091 41.4 µM 4.55520957055856 2.59546318397549e-05 yes 23 2.61666881932654e-06 17 627384 YHR062C RPP1 SGTC_146 3448-8650 53.125 µM 4.48820027770195 3.34258854939317e-05 yes 24 3.59136940343502e-06 110 2891488 YIL048W NEO1 SGTC_1055 3448-0672 86 µM 4.48501804455766 3.38270293813729e-05 yes 25 3.6453882183888e-06 18 748378 SGTC_2526 patulin 37.61 µM 4.4651919297401 3.6430711022065e-05 yes 26 3.99985027057676e-06 64 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1310 1188-0297 994 nM 4.37997989470059 4.99358346230403e-05 yes 27 5.93451296589695e-06 24 1588352 SGTC_149 3970-0822 46.1 µM 4.36406202813583 5.29334830613905e-05 yes 28 6.38346756924194e-06 73 3114250 YBL034C STU1 SGTC_3216 9129716 49.47 µM 4.3586155037413 5.39975932782576e-05 yes 29 6.54439186846068e-06 17 8056934 SGTC_1174 0739-0097 51.1 µM 4.3271483702025 6.05514422848765e-05 yes 30 7.55261080693948e-06 18 728447 SGTC_2810 7959871 45.46 µM 4.20331043492846 9.43565581858258e-05 yes 31 1.31519724205478e-05 32 2974535 SGTC_431 k089-0097 107 µM 4.14366971175967 0.000116349967896761 yes 32 1.70895957868998e-05 36 5499420 SGTC_313 3474-0040 5.03 µM 4.10456261668402 0.00013329166166276 yes 33 2.02540272510524e-05 66 1043375 YIL048W NEO1 SGTC_2003 4023581 200 µM 3.98495626468946 0.000200573865144872 yes 34 3.37462777169941e-05 34 16641307 SGTC_208 k072-0098 12.366 µM 3.92664778905167 0.000243841170010757 yes 35 4.30689867662166e-05 44 5948901 SGTC_2026 5148700 152 µM 3.90826382383157 0.00025919407117723 yes 36 4.64808808735064e-05 17 79838 SGTC_414 piperonyl butoxide 100 µM 3.89927811448314 0.000267021769907879 yes 37 4.82399525723511e-05 9 5794 A potent inhibitor of cytochrome P450. SGTC_2546 rhodinyl acetate 100 µM 3.87675138448507 0.000287624229967151 yes 38 5.29302146417237e-05 13 6708682 SGTC_2785 7756463 72.73 µM 3.83189498884356 0.000333128032536638 yes 39 6.35800086976585e-05 32 2201551 SGTC_301 4119-0100 24.5 µM 3.79609513868176 0.000374154730040704 yes 40 7.34965532639676e-05 85 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1164 k060-0068 93.7 µM 3.78366418849279 0.000389465352819378 yes 41 7.72681490547346e-05 30 5963676 SGTC_1495 4469-0029 237 µM 3.71608389513641 0.00048337613434544 yes 42 0.000101167211687563 125 793680 SGTC_123 0083-0120 66.675 µM 3.7132359424402 0.000487760255861593 yes 43 0.000102312976415716 55 16001701 SGTC_1718 roemerine 11.9335 µM 3.6403746561928 0.0006132478233282 yes 44 0.000136120807148127 68 235224 An aporphine alkaloid with mutagenic activity. SGTC_2030 5175110 200 µM 3.63570783562621 0.000622223278205298 yes 45 0.000138609191921021 35 2831986 SGTC_2407 paclitaxel 400 µM 3.59412594532105 0.000707720240107659 yes 46 0.000162741187946901 51 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_717 1532-0246 73.2 µM 3.55684308776991 0.000793456429723741 yes 47 0.000187669095918977 45 9561992 SGTC_263 alizarin 107.927 µM 3.53180270870503 0.000856301180677967 yes 48 0.000206368582570575 78 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1195 1502-0147 41.1 µM 3.46822346888932 0.00103698880516015 no 49 0.000261955710905742 44 817940 SGTC_488 nitrendipine 139 µM 3.44830996602943 0.00110039825508436 no 50 0.000282053132176099 64 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2730 imipramine 71.33 µM 3.40863217730199 0.00123745578482159 no 51 0.000326447235544122 46 3696 A tricyclic antidepressant. SGTC_805 3852-0218 479 µM 3.39822389365906 0.00127590775930458 no 52 0.000339124438193873 92 6615355 SGTC_598 3937-0236 20.2 µM 3.3709057775343 0.00138208573058752 no 53 0.000374607389344623 45 1379313 SGTC_1334 1486-0610 236 µM 3.36361838966892 0.00141174233557485 no 54 0.000384639166963879 37 3742339 SGTC_1721 st082152 9.2685 µM 3.36210664315862 0.00141796681931588 no 55 0.000386751221498986 41 5296051 SGTC_1963 st076565 50.3 µM 3.35685160931202 0.00143979941328779 no 56 0.000394177055685125 27 4914280 SGTC_767 0929-0023 86 µM 3.35505680850158 0.00144732611949805 no 57 0.000396743439529823 121 1204563 SGTC_2200 6600604 21.907 µM 3.3531299796023 0.00145544646199677 no 58 0.000399515865331464 70 2904777 SGTC_847 0342-0274 5.54 µM 3.34865488187167 0.00147446679734708 no 59 0.000406024394069197 34 18097 SGTC_466 geldanamycin 89.2 µM 3.32638330530942 0.00157254379744102 no 60 0.000439904252904295 20 5288382 HSP90 inhibitor. SGTC_339 3091-4833 71.4 µM 3.32577311422852 0.00157531270049382 no 61 0.000440868348956272 33 3240077 SGTC_3322 9139058 2.11 µM 3.32119232812611 0.00159624155574497 no 62 0.000448168736619028 52 4908926 YPR165W RHO1 SGTC_2675 theaflavin digallate 100 µM 3.30024326252826 0.00169522124990479 no 63 0.00048300527406189 57 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2352 9027995 87.8 µM 3.28742589036503 0.00175850353629056 no 64 0.00050553898625722 49 2997347 SGTC_770 0389-1121 67.2 µM 3.25501507388733 0.00192822619773153 no 65 0.000566931737725977 57 6753108 SGTC_457 grayanotoxin iii 135 µM 3.2520344284148 0.00194455893610839 no 66 0.000572910708964558 120 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2021 4019055 173 µM 3.25065338513416 0.00195216901513976 no 67 0.000575700699267984 187 44827708 YER133W GLC7 SGTC_444 curcumin 90.4 µM 3.22991965202477 0.00206971814445166 no 68 0.000619125056999924 49 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1480 1070-0044 41.2 µM 3.22080397959421 0.00212340282724044 no 69 0.000639157739347853 40 3124987 SGTC_1329 1447-1697 50.6 µM 3.21385374570873 0.00216517977823496 no 70 0.000654831819049427 34 2840515 SGTC_1504 k297-0033 30 µM 3.2016926572113 0.0022400748713077 no 71 0.000683113405040467 34 4388117 SGTC_1554 st069299 38.7 µM 3.19966747949837 0.00225277265876931 no 72 0.00068793111802892 44 24207999 SGTC_1877 wortmannin 25 µM 3.1843362657663 0.00235103396876154 no 73 0.000725431818838816 132 312145 A covalent inhibitor of PI 3-kinase. SGTC_687 k029-0044 34.9 µM 3.179468489414 0.00238303465861741 no 74 0.000737727051709724 48 5829338 SGTC_2210 7115885 190.385 µM 3.16739620989193 0.00246410560392084 no 75 0.000769053015358751 58 2927039 SGTC_2268 7933382 153.85 µM 3.13879316671551 0.00266623421845929 no 76 0.000848225719726275 65 935025 YOR257W CDC31 SGTC_1832 st054113 55 µM 3.12209116165407 0.00279107309221419 no 77 0.000897856624840121 19 1251267 SGTC_2586 curcumin 80 µM 3.09937285759116 0.00296934494249315 no 78 0.000969653966687649 103 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1196 1588-0294 184 µM 3.08509978617322 0.00308653101840073 no 79 0.00101741935721856 41 6144269 SGTC_573 3702-0553 84.7 µM 3.06096725159226 0.00329416850507785 no 80 0.00110311611809519 42 1222756 SGTC_1063 disulfiram 1.84 µM 3.05162272360112 0.00337788560686206 no 81 0.00113803991642638 70 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1377 2944-0135 198 µM 3.02964668478235 0.00358235135165913 no 82 0.00122419988520459 89 1894137 SGTC_2647 atorvastatin 60.16 µM 2.99936339928722 0.00388230371009296 no 83 0.00135272204509256 45 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1482 3346-2049 8.48 µM 2.99796708967 0.00389666153220858 no 84 0.00135893510516203 66 3826804 SGTC_1978 st071761 42 µM 2.97559778558246 0.0041332548703055 no 85 0.0014620905354117 39 5147680 SGTC_124 0136-0217 7.121 µM 2.9646835637711 0.00425329163290413 no 86 0.00151497208217855 113 3976905 SGTC_2661 dactinomycin 12.96 µM 2.95894102882738 0.00431769253283877 no 87 0.00154349084247011 71 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2300 7976697 71.57 µM 2.9573311602399 0.00433590249733933 no 88 0.00155157321580382 78 2236109 SGTC_1752 st044819 83.042 µM 2.91258495398419 0.00487030624309763 no 89 0.00179225341236619 70 441209 YML126C ERG13 SGTC_2912 7964298 10.93 µM 2.90454635375551 0.00497230288518644 no 90 0.00183892869367693 159 2975850 SGTC_1825 st052143 62.6 µM 2.89842278683778 0.00505127326808567 no 91 0.00187522321264732 50 674173 SGTC_2161 5662504 8.5105 µM 2.89123499396887 0.00514539141014663 no 92 0.0019186553488443 72 2859334 SGTC_976 1348-1067 47.6 µM 2.88598357389653 0.00521513787433853 no 93 0.0019509626070391 85 5310671 YGL099W LSG1 SGTC_10 0279-0212 42.575 µM 2.88497960274512 0.00522856744293416 no 94 0.0019571951120623 207 39851 YBR002C RER2 SGTC_554 4483-2211 187 µM 2.88057526346911 0.00528784610653925 no 95 0.0019847508295144 64 747107 SGTC_848 0368-0089 85.6 µM 2.85736100654932 0.005610276666012 no 96 0.00213589839801376 58 762535 SGTC_582 0987-0078 156 µM 2.85652261094571 0.00562224128068992 no 97 0.00214154748251611 164 1625765 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.85158970739146 0.00569309793963172 no 98 0.0021750604844774 162 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2944 9067346 25.62 µM 2.84952625955006 0.0057229718859818 no 99 0.00218921956136376 88 6473075 SGTC_537 1334-0398 209 µM 2.83953419035204 0.00586961091425228 no 100 0.00225897265993745 81 5846986 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.82013176839209 0.0061639001232557 no 101 0.00240019665128194 67 5106787 A p450 inhibitor. SGTC_3274 9138298 49.47 µM 2.81748070551491 0.00620510918378288 no 102 0.00242010113709973 78 17015756 SGTC_2957 9076800 11.52 µM 2.78999525764021 0.00664694532709499 no 103 0.00263544068006443 71 16459615 SGTC_3054 9094397 49.47 µM 2.75010019107508 0.00733772702804716 no 104 0.00297885226675602 107 2598354 SGTC_1658 st012944 20 µM 2.73973065277289 0.00752732916578408 no 105 0.0030744776389443 129 24207260 SGTC_3056 9094900 49.47 µM 2.73880641599401 0.00754443602663504 no 106 0.00308313347636412 88 25236784 SGTC_843 0310-0051 143 µM 2.73474614208524 0.00761999463375152 no 107 0.00312142005622731 74 2065037 SGTC_1067 clotrimazole 1.36 µM 2.73234928915185 0.00766491031170528 no 108 0.00314422171616046 112 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_91 0417-1751 58.384 µM 2.72677701838292 0.00777023338469335 no 109 0.00319781213157849 138 6795624 SGTC_351 caspofungin 25 nM 2.72068010119318 0.00788693002714059 no 110 0.00325738863856809 208 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2627 acetyl isogambogic acid 100 µM 2.71470926925779 0.00800270459714514 no 111 0.00331669877943466 124 6857789 A caspase activator and apoptosis inducer. SGTC_1712 st032288 53.4 µM 2.70655452298087 0.00816323802036434 no 112 0.00339927087674005 309 2883011 SGTC_1426 4048-4480 71.7 µM 2.69630038943656 0.00836911084112417 no 113 0.00350572031166022 79 14224343 SGTC_2389 9091542 195.52 µM 2.67922673614106 0.00872202278215706 no 114 0.00368962035920737 115 3626624 YOL127W RPL25 SGTC_1158 4092-0494 91.8 µM 2.66618207306546 0.00900038282527497 no 115 0.00383590655899124 82 1148199 SGTC_2296 7971656 126.45 µM 2.66536260091775 0.00901812646689946 no 116 0.00384526754822242 122 666570 SGTC_607 4491-0986 66.8 µM 2.62766883453136 0.00986811123744935 no 117 0.00429860834278711 100 698981 YDR232W HEM1 SGTC_481 bay k-8644 50 µM 2.6156306813017 0.0101539234819965 no 118 0.00445314162982994 90 2303 A calcium channel antagonist. SGTC_2403 6032726 181.2 µM 2.6091748021988 0.0103101549916924 no 119 0.00453804332185435 122 2881040 SGTC_2013 4024628 200 µM 2.59873799380892 0.0105671588597913 no 120 0.00467835796416861 136 5230760 SGTC_1839 st053978 48 µM 2.54960179875898 0.0118535060719011 no 121 0.00539230102754835 112 3788398 SGTC_2619 obliquin 87.91 µM 2.5421889194668 0.0120589162142914 no 122 0.0055080306510876 280 6708593 A bioactive alkalod. YER133W GLC7 SGTC_796 1234-0020 70.7 µM 2.5419512569748 0.0120655525642627 no 123 0.00551177726651346 101 46495034 SGTC_2688 kanamycin b 96.69 µM 2.53909013314395 0.0121456937782343 no 124 0.00555705930265243 630 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1550 gossypolone 36.6 µM 2.5347781291929 0.0122673463254381 no 125 0.00562592831400288 112 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_612 0302-0167 22.4 µM 2.53464248961369 0.0122711901280337 no 126 0.00562810691844934 145 235821 SGTC_1326 1431-2094 10.8 µM 2.528129325911 0.0124569947740588 no 127 0.00573360516279644 115 616278 SGTC_918 glabranin 770.725 nM 2.51324122611208 0.0128908876636002 no 128 0.00598137525862988 123 124049 Also referred to as licorice root. SGTC_1711 st032263 62.8 µM 2.49302419537855 0.0135009706887285 no 129 0.0063330107451614 96 3958979 SGTC_296 1222-0039 74.9 µM 2.47904365329732 0.0139372941994186 no 130 0.00658675911570184 100 5984176 SGTC_1086 cerivastatin 2.18 µM 2.47874684611376 0.0139466876338936 no 131 0.00659224228553556 81 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_820 1582-0060 59.9 µM 2.47581448886005 0.0140397853871956 no 132 0.00664663147747289 135 3848840 SGTC_879 0831-1030 162 µM 2.45280212171283 0.0147891642025503 no 133 0.00708741449707378 187 1549252 SGTC_2351 9026858 72.31 µM 2.44417522229954 0.0150788274923304 no 134 0.0072591866673529 130 1409300 SGTC_452 diindolylmethane 8 µM 2.43658460309506 0.0153377148507099 no 135 0.00741335032543706 86 3071 Inhibits expression of several cancer promoting factors. SGTC_2897 9048598 12.99 µM 2.43219577099029 0.015489135795764 no 136 0.00750379660372929 103 6467404 SGTC_1054 3429-0080 167 µM 2.43135840522489 0.0155181714094502 no 137 0.00752116327070626 141 1162877 SGTC_1153 4055-0057 267 µM 2.42717966302609 0.015663768341511 no 138 0.00760835910724701 141 882706 SGTC_962 1254-0300 21.5 µM 2.42625706279259 0.015696071321842 no 139 0.00762773009863938 111 7340576 SGTC_1923 st058458 19.1 µM 2.39966006244239 0.0166521935599667 no 140 0.00820515177265463 182 3534982 SGTC_2011 4012611 177 µM 2.39912100316622 0.0166720761787775 no 141 0.0082172414212581 148 2049887 SGTC_2596 sinensetin 100 µM 2.38384713122666 0.017243937761008 no 142 0.00856635881868059 142 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2231 micatex 6.853 µM 2.37728009462373 0.0174949150893819 no 143 0.00872041945318435 92 20737 An antifungal of unknown mechanism. SGTC_139 0099-0334 718.624 µM 2.36825737890777 0.0178448241948856 no 144 0.00893604904389788 180 97690 SGTC_2582 agaric acid 100 µM 2.36498401479953 0.0179732355171614 no 145 0.00901542458496903 559 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1285 0929-0069 65.5 µM 2.36118969827404 0.018123068578255 no 146 0.00910820485834854 146 1206237 SGTC_1558 st069300 45.6 µM 2.35683131859418 0.018296488414394 no 147 0.00921580860040395 82 24208000 SGTC_3330 9141424 71.43 µM 2.35325782457321 0.0184397306231568 no 148 0.0093048628323772 138 27261020 SGTC_994 3910-0338 138 µM 2.34398402390992 0.0188159300596847 no 149 0.00953949430869908 167 3479481 SGTC_3219 9131112 49.47 µM 2.32418035437876 0.0196411876759493 no 150 0.0100579148894168 148 17612988 YMR079W SEC14 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.3234687665353 0.0196714041103365 no 151 0.0100769918267878 192 2724 A muscle relaxant with antifungal properties. SGTC_609 0986-0026 86.3 µM 2.32185461509749 0.0197400927906791 no 152 0.0101203826490866 180 2848610 SGTC_70 0141-0289 43.283 µM 2.32130300586441 0.0197636126270969 no 153 0.0101352480632889 412 352408 SGTC_300 r073-0011 5.04 µM 2.31301911526883 0.020119696795352 no 154 0.0103607940984168 149 2735780 SGTC_1049 3226-0134 66 µM 2.31201406228854 0.0201632669945391 no 155 0.0103884541917052 176 5702385 SGTC_3180 9109287 49.47 µM 2.30864612508036 0.0203098546742907 no 156 0.0104816130954505 131 18891271 SGTC_1782 st039423 80.636 µM 2.30259282473394 0.0205755926520295 no 157 0.0106508816254282 161 2068169 SGTC_148 3253-0744 288.01 µM 2.30255891621519 0.0205770894818065 no 158 0.0106518364763256 150 6893655 SGTC_2226 7298446 200 µM 2.3015781584079 0.0206204231844661 no 159 0.0106794865228188 85 3283010 SGTC_2275 7947463 200 µM 2.29133098013951 0.0210778247296083 no 160 0.0109721390602726 134 1225414 SGTC_3026 9090633 49.47 µM 2.2856181241948 0.0213365352420253 no 161 0.0111383044612595 157 25236842 SGTC_2896 9052656 71.43 µM 2.28410933488974 0.0214053082864293 no 162 0.011182553053595 334 6469436 SGTC_2958 9077254 16.72 µM 2.27992205173744 0.0215971538767419 no 163 0.0113061559673327 168 16457351 SGTC_446 go6976 132 µM 2.27815438364657 0.0216785768701727 no 164 0.0113586905099652 118 3501 A protein kinase C inhibitor. SGTC_834 0312-0008 75.7 µM 2.26886598011374 0.0221106967470677 no 165 0.0116382385477588 193 6385573 YIL048W NEO1 SGTC_2455 5377712 9.75 µM 2.26787612659426 0.022157172952057 no 166 0.0116683789033242 144 2243908 SGTC_1788 fluconazole 20 µM 2.26703432159861 0.0221967627370229 no 167 0.0116940645767761 189 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_947 3447-0010 211 µM 2.2647121749918 0.0223062820140388 no 168 0.0117651739319204 137 748350 SGTC_3341 9147222 25.867 µM 2.26388324929455 0.0223454868424711 no 169 0.0117906482304245 130 1939759 SGTC_3049 9092223 49.47 µM 2.25964370423119 0.0225469101465684 no 170 0.011921686417177 141 8623917 SGTC_1724 st037281 8.293 µM 2.253239500392 0.0228540792114548 no 171 0.0121220260339082 208 574124 YDL195W SEC31 SGTC_1105 epirubicin 18.1 µM 2.25323390332963 0.022854349201441 no 172 0.0121222023927534 142 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_579 4491-1009 110 µM 2.23741460978159 0.0236282500601768 no 173 0.0126296272740838 212 1271041 SGTC_2151 5563267 85.4165 µM 2.23244289552634 0.0238759788531916 no 174 0.0127928527114618 174 5310824 SGTC_957 1187-1561 14.1 µM 2.2305611324514 0.0239703104717201 no 175 0.0128551069023707 170 1538454 SGTC_670 4204-0025 119 µM 2.22884488526673 0.0240566177736383 no 176 0.0129121136429748 180 719039 SGTC_345 1362-0200 395 µM 2.22668077378467 0.0241658194915849 no 177 0.012984308137012 156 1419823 SGTC_1579 chlormadinone acetate 49.4 µM 2.22073933305743 0.0244677691479249 no 178 0.0131843108633095 144 45114258 A steroidal progestin. SGTC_905 2-aminofluorene 215 µM 2.2017080685435 0.0254563527931059 no 179 0.0138429682110412 184 1539 An established DNA mutagen. YPR165W RHO1 SGTC_475 α-linolenic acid 10 µM 2.19832666084252 0.0256354547034351 no 180 0.0139629179094692 182 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1826 st055655 41.6 µM 2.19752208683817 0.025678225329867 no 181 0.0139915904171681 190 676168 SGTC_672 1441-0018 53.7 µM 2.18564935976438 0.0263163471103662 no 182 0.0144206342200467 153 251141 SGTC_1047 2043-3044 82 µM 2.16787631763525 0.0272963272916981 no 183 0.0150840490899758 203 669592 SGTC_709 3807-1509 243 µM 2.16544424063774 0.02743276666556 no 184 0.0151768405766786 125 1886677 YPL242C IQG1 SGTC_562 3772-2733 112 µM 2.16129780477128 0.0276666925525207 no 185 0.0153361711990203 243 2876874 YIL048W NEO1 SGTC_1414 3917-0015 5.4 µM 2.1578676794019 0.0278614612963163 no 186 0.0154690605113118 141 6618702 SGTC_746 1095-0025 46.6 µM 2.1575845902283 0.0278775865127494 no 187 0.0154800719255366 172 6749286 SGTC_2862 9027634 71.43 µM 2.14584650978039 0.0285530827291906 no 188 0.0159426132837521 181 5012562 SGTC_406 estrone 100 µM 2.12975922977086 0.0295009304957403 no 189 0.0165957481144751 149 5870 A steroid. SGTC_2679 rapamycin 1 nM 2.12780453870644 0.0296178587323925 no 190 0.0166766464549313 354 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_738 1315-0003 72.4 µM 2.123816799498 0.0298575953845254 no 191 0.0168427328379965 196 6251474 SGTC_1292 0kpi-0043 232 µM 2.11602175714684 0.0303308703691851 no 192 0.0171714785875269 169 3333905 SGTC_1545 lovastatin 49.4 µM 2.1069915416746 0.0308868937706506 no 193 0.0175591563789777 225 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_645 0845-0943 5.41 µM 2.10523831346071 0.03099581857585 no 194 0.01763528436298 170 1885106 SGTC_1899 st063254 59.6 µM 2.10013430685205 0.0313147319936134 no 195 0.0178585140974981 149 3093813 SGTC_3133 9127736 49.47 µM 2.0984824261345 0.03141852577441 no 196 0.0179312753663202 176 27243420 SGTC_1078 idebenone 36.1 µM 2.0939583264774 0.0317042487495425 no 197 0.0181318463653347 271 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3295 9122362 53.5725 µM 2.09174557890221 0.0318447764361607 no 198 0.0182306404545722 165 4730473 SGTC_157 1348-1695 65.819 µM 2.08328621828078 0.0323867669181659 no 199 0.0186125711009343 290 5380510 SGTC_3127 9126946 49.47 µM 2.08196006622382 0.0324724195461452 no 200 0.0186730587364567 159 27243249 SGTC_1286 0929-0070 131 µM 2.07402244027481 0.0329890045644228 no 201 0.0190386134137272 214 1420408 SGTC_1952 st077036 64.1 µM 2.07256143475982 0.0330848216974416 no 202 0.0191065566243007 215 2937007 SGTC_727 3032-0951 202 µM 2.06747417076802 0.0334202506324392 no 203 0.0193447477965758 192 3652836 SGTC_3090 9117696 49.47 µM 2.06657799350988 0.0334796292042921 no 204 0.019386968106806 163 7923821 SGTC_2183 6420625 130.508 µM 2.06291041759748 0.0337235397708086 no 205 0.0195605700832097 293 2897619 SGTC_2153 5569715 200 µM 2.06222948062711 0.0337689857412207 no 206 0.0195929466165097 154 2054701 SGTC_956 1185-0240 191 µM 2.05289964437769 0.0343967527217251 no 207 0.0200411557650367 204 1416193 SGTC_2539 epi(13)torulosol 80 µM 2.05265871605062 0.0344130899791864 no 208 0.0200528443156708 211 6708597 SGTC_2873 9040596 71.43 µM 2.0496528446423 0.0346174534871228 no 209 0.0201991598447233 232 6463863 SGTC_3142 9086498 49.47 µM 2.04809297844053 0.0347238980707556 no 210 0.0202754448972901 203 25236367 SGTC_121 0557-0495 61.343 µM 2.04763568890072 0.0347551542052687 no 211 0.0202978548255523 334 3104427 SGTC_516 3992-2719 87.3 µM 2.04061251546159 0.0352381028658546 no 212 0.020644678593747 195 5350887 YDR037W KRS1 SGTC_1768 st044301 37.178 µM 2.03341490939713 0.0357387444750484 no 213 0.0210053111503962 208 3931349 SGTC_68 0986-0284 82.829 µM 2.0326899686859 0.0357894904590682 no 214 0.0210419276994941 278 423278 YIL048W NEO1 SGTC_1436 4092-1007 8.32 µM 2.03142535484631 0.0358781549878055 no 215 0.0211059322763619 193 2881121 SGTC_885 0865-0106 16.8 µM 2.02750282496443 0.0361543165482642 no 216 0.0213055079184345 231 2793380 SGTC_1987 st072290 61.9 µM 2.02712027446133 0.0361813425117363 no 217 0.0213250569569562 195 54697379 SGTC_417 st075190 100 µM 2.00337992490203 0.0378911607512822 no 218 0.0225682622812069 217 222757 SGTC_3355 9151058 44.0485 µM 2.00068430442754 0.0380894048585975 no 219 0.022713210964585 206 17015728 SGTC_376 3970-0862 59.1 µM 1.99828296533825 0.0382667183788348 no 220 0.0228429956223999 219 3135186 SGTC_2420 aureobasidin a 50 nM 1.99636804441577 0.0384085969135656 no 221 0.0229469382349381 280 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.99223341303329 0.0387163987860482 no 222 0.0231727268764079 235 5282309 SGTC_176 1486-1328 72.834 µM 1.98715584288759 0.0390971436422193 no 223 0.0234525647457602 291 22310231 SGTC_126 0417-1624 672.48 µM 1.98491188929129 0.0392663763898643 no 224 0.0235771376864475 303 41912 YDL195W SEC31 SGTC_120 rhodamine 6G 52.259 µM 1.98253472364462 0.0394463053871581 no 225 0.023709712515263 297 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2984 9022109 38.96 µM 1.97531456503628 0.039996919094597 no 226 0.0241162306852189 146 6459207 SGTC_3132 9126706 49.47 µM 1.97260882472376 0.0402048626295262 no 227 0.0242700734081327 205 850858 SGTC_333 3486-0131 40.1 µM 1.96553575105414 0.0407525983019647 no 228 0.0246761310154822 213 6744690 SGTC_3344 9148862 3.898 µM 1.95493150451419 0.0415851154117322 no 229 0.0252955777179048 210 4905352 SGTC_2137 5261020 140 µM 1.95412813846351 0.0416487433984149 no 230 0.0253430325613736 244 763655 SGTC_235 0330-0087 5 mM 1.95296568707057 0.041740951158231 no 231 0.0254118305960814 252 46494818 YHR062C RPP1 SGTC_1013 4112-3890 241 µM 1.95126900000709 0.0418758321642441 no 232 0.0255125273521078 247 705171 SGTC_2516 gossypol 71.55 µM 1.95056908964735 0.0419315754395486 no 233 0.0255541636042568 243 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1327 1436-0082 2.18 µM 1.94775544134977 0.0421562705511597 no 234 0.0257221163842286 223 15992205 SGTC_1854 st056233 32.9 µM 1.94213618052679 0.042607935056547 no 235 0.0260603082661469 224 5393174 SGTC_902 1120-0002 2.07 µM 1.94194537534947 0.0426233399988282 no 236 0.0260718567385971 283 3280475 SGTC_900 1112-0045 141 µM 1.94058497287668 0.0427333046891471 no 237 0.0261543191287938 173 56211 YIL048W NEO1 SGTC_2659 sanguinarine 24.21 µM 1.93774665916254 0.042963470971455 no 238 0.0263270691792172 227 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1557 sumaresinolic acid 42.3 µM 1.93496660076562 0.043189883213895 no 239 0.0264971971742232 236 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1393 3470-5649 58.2 µM 1.93289631462069 0.043359115753419 no 240 0.0266244859875938 174 4108395 SGTC_377 3970-0964 33.1 µM 1.92985080321122 0.0436090393481202 no 241 0.0268126633107349 346 16481235 SGTC_1505 k297-0037 20.6 µM 1.92615655963183 0.0439137588034167 no 242 0.0270424140575768 247 4089396 SGTC_324 1315-0088 19.6 µM 1.91122140772594 0.0451632313528496 no 243 0.0279880669505438 183 6787421 SGTC_1028 k015-0029 4.8 µM 1.90885881261152 0.0453634810383057 no 244 0.0281401537474461 294 4588309 SGTC_2842 9000675 19.48 µM 1.90557542590797 0.0456429607427937 no 245 0.0283526564660652 244 2989072 SGTC_1460 k062-0059 9.15 µM 1.90548999392311 0.0456502510922349 no 246 0.028358203451271 237 1373085 SGTC_833 3852-0053 558 µM 1.90321948702021 0.0458443483631798 no 247 0.0285059557084218 267 3123681 SGTC_2077 5212015 200 µM 1.90197195912784 0.0459512769014899 no 248 0.0285874102896974 279 780900 SGTC_2825 7998094 58.44 µM 1.9000782893979 0.0461139706136969 no 249 0.0287114231754222 242 2987815 SGTC_232 clozapine 119 µM 1.8939881703035 0.046640338949345 no 250 0.029113290044181 284 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_534 k292-0788 63.4 µM 1.89295730208154 0.0467299120294224 no 251 0.0291817739482126 278 4146317 SGTC_2423 st077119 87.2 µM 1.88339262525266 0.0475675917793516 no 252 0.0298235895209285 251 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2124 5246320 200 µM 1.88208739119267 0.0476828318822703 no 253 0.0299120755201081 253 579342 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.8817440460373 0.0477131832001358 no 254 0.0299353881278349 257 6312947 SGTC_1925 st057770 10.1 µM 1.88032097924555 0.0478391456553644 no 255 0.0300321728892444 242 5989122 SGTC_718 1130-0073 349 µM 1.87767078227079 0.0480744367749293 no 256 0.0302131080417714 272 6740020 SGTC_3174 9107204 49.47 µM 1.87110873800516 0.0486610179791954 no 257 0.0306650053450886 264 3938802 SGTC_1776 st049249 45.9 µM 1.86967144529155 0.0487902583342764 no 258 0.0307647285799342 282 1822314 SGTC_535 2293-4129 48.2 µM 1.86951259588479 0.0488045587810122 no 259 0.0307757664372005 340 396118 YIL048W NEO1 SGTC_145 3737-0113 38.366 µM 1.868643714809 0.0488828392399252 no 260 0.0308361997950002 367 6849351 SGTC_892 0929-0076 29 µM 1.8682118066239 0.0489217886357667 no 261 0.0308662768734633 330 5751038 SGTC_3044 9093193 49.47 µM 1.86680637810154 0.0490487015563102 no 262 0.0309643157500519 295 25236277 SGTC_2567 aureobasidin a 60 nM 1.8618611207663 0.0494973599444273 no 263 0.0313113342550576 354 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2241 6772625 37.8075 µM 1.86069258747826 0.0496038521208177 no 264 0.0313938006176931 248 2285411 SGTC_480 am 92016 50 µM 1.85549426099317 0.0500798098651813 no 265 0.0317628390032614 203 2129 K+ channel blocker. SGTC_971 1315-0384 26.7 µM 1.85334647125057 0.0502775210257936 no 266 0.0319163571920994 272 6769120 SGTC_1844 rapamycin 4 nM 1.85323670158425 0.05028764237331 no 267 0.0319242196623925 442 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.85059610379285 0.0505316092995322 no 268 0.0321138403314772 368 6708739 YPR165W RHO1 SGTC_2895 9054447 58.44 µM 1.84510241523277 0.0510421966339447 no 269 0.0325113209752392 219 2697450 SGTC_928 2764-0428 58.7 µM 1.8428717274343 0.0512506869146581 no 270 0.0326738705533872 310 662578 SGTC_52 0329-0193 875 nM 1.83740772658333 0.0517642402017595 no 271 0.0330748635188153 279 3739292 SGTC_2522 biochanin a 4.94 µM 1.83675575432784 0.0518257902935164 no 272 0.0331229801969799 242 5280373 A possible chelator. SGTC_210 3551-0445 56.827 µM 1.83604820083231 0.0518926533867921 no 273 0.0331752641052967 294 2865180 YOR207C RET1 SGTC_262 fenpropimorph 62.5 µM 1.82437158103983 0.0530060123016239 no 274 0.0340479576923895 258 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_15 0266-0086 27.098 µM 1.82251997486177 0.053184289308829 no 275 0.0341880628535965 367 1712902 YIL048W NEO1 SGTC_1994 st072947 40.9 µM 1.82236604525163 0.0531991313904965 no 276 0.0341997315254068 288 5286565 YDL195W SEC31 SGTC_1233 0325-0408 14.2 µM 1.82148353758962 0.0532842872486404 no 277 0.0342666934414289 277 12874 SGTC_2674 ligustilide 100 µM 1.81496260106377 0.0539168654828208 no 278 0.0347648285143457 217 5319022 A signalling regulator. SGTC_2768 sulfasalazine 50.2 µM 1.81454093719867 0.0539579737392544 no 279 0.0347972430826398 266 5384001 An antioxidant and salicylic acid derivative. SGTC_74 000s-0487 160.283 µM 1.81112158711142 0.0542922452744064 no 280 0.0350610163153805 288 677548 SGTC_2780 5215298 71.43 µM 1.80336310278557 0.055056781479863 no 281 0.0356656041610108 321 2834131 SGTC_2110 5483698 200 µM 1.79948336948271 0.0554422754139836 no 282 0.0359711261432349 266 2848765 YHR062C RPP1 SGTC_3135 9127742 49.47 µM 1.79938210969861 0.0554523651442746 no 283 0.0359791287850177 241 3643468 SGTC_1588 farnesol 29.9 µM 1.79873767902074 0.0555166114999432 no 284 0.0360300928364744 291 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2112 5488546 200 µM 1.79781524430316 0.0556086756361663 no 285 0.036103145385823 314 600757 SGTC_2507 purpurin 79.67 µM 1.7929053797073 0.0561007368860096 no 286 0.0364940275007708 313 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_824 1304-0008 100 µM 1.78793485178022 0.0566023688331846 no 287 0.0368932596111656 331 768245 SGTC_2418 pentamidine 31.67 µM 1.78508760903534 0.0568913041935253 no 288 0.0371235537522032 301 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3028 9087778 49.47 µM 1.78405135002054 0.056996750552675 no 289 0.0372076607571665 259 17217395 SGTC_2379 9035213 200 µM 1.78118959728888 0.0572887525866618 no 290 0.0374407412583895 292 646551 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.7759775112218 0.0578235965938151 no 291 0.0378683119508328 339 165506 SGTC_288 1315-0019 35.1 µM 1.7746711186819 0.0579582668954086 no 292 0.0379761033897966 294 6811474 SGTC_648 0375-0473 33.3 µM 1.77260099749434 0.0581721713214068 no 293 0.0381474231659119 326 1713139 SGTC_2344 7990960 76.95 µM 1.77086321028478 0.0583522143290381 no 294 0.0382917257359814 285 140813 SGTC_23 0213-0011 39.996 µM 1.76792578488838 0.0586575403606392 no 295 0.038536655759133 287 627608 SGTC_2459 5811157 9.22 µM 1.7640615627023 0.0590611092219723 no 296 0.0388608074708789 293 2870684 YBR192W RIM2 SGTC_2543 pimpinellin 60.67 µM 1.76405122181168 0.0590621921111376 no 297 0.0388616778903676 293 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1526 st051518 75 µM 1.76279785067159 0.0591935594420621 no 298 0.0389672950304623 288 673993 SGTC_1007 4101-0031 70 µM 1.76123126286076 0.0593580774578481 no 299 0.0390996343460757 307 1146276 SGTC_2028 5153890 36.43 µM 1.75794227403105 0.0597046427110842 no 300 0.0393786659535002 296 2830968 YPR165W RHO1 SGTC_1870 st057514 26.5 µM 1.75790232757008 0.0597088616482113 no 301 0.0393820648680846 296 5393161 SGTC_2327 6189656 200 µM 1.74761925110527 0.0608026975185079 no 302 0.0402649897852121 277 5349088 SGTC_2190 6049624 200 µM 1.74743616006837 0.0608223143976669 no 303 0.0402808548328433 233 2265554 SGTC_257 daunorubicin 18.5 µM 1.74659158277682 0.0609128688166837 no 304 0.0403541041590865 250 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_806 3966-4455 5.86 µM 1.74298690504263 0.0613005429065542 no 305 0.0406679511171379 273 714982 SGTC_1311 1190-0148 100 µM 1.74091488525824 0.0615242543986399 no 306 0.0408492495587232 379 1961333 SGTC_581 0958-0271 211 µM 1.73749500269407 0.0618948857749718 no 307 0.0411499176671097 396 4591145 SGTC_946 3434-1334 87.4 µM 1.73385857421476 0.0622908945979943 no 308 0.0414715898336729 301 4047976 SGTC_1965 Pectolinarigenin 58.4 µM 1.7266713094082 0.0630794009963603 no 309 0.0421133555670233 288 5320438 An anti-inflammatory. SGTC_16 erodoxin 22.806 µM 1.72514230797319 0.0632481444804749 no 310 0.0422509148052588 410 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_147 4466-0538 29.23 µM 1.72165163204026 0.0636346990609165 no 311 0.0425663220304851 355 6742687 YHR072W ERG7 SGTC_1931 st074438 57.1 µM 1.71770990841589 0.0640734093807686 no 312 0.0429247705797031 284 2787313 SGTC_363 0455-0021 3.06 µM 1.71704148357147 0.0641480371054466 no 313 0.0429857963249589 375 4597466 SGTC_878 0828-0289 13.7 µM 1.71065130020385 0.0648648976299263 no 314 0.043572751396871 398 745350 YLR208W SEC13 SGTC_799 1310-0557 151 µM 1.70833776109738 0.0651259620800883 no 315 0.0437868442538787 336 5354492 SGTC_619 1652-1634 108 µM 1.70204821283903 0.0658398093369062 no 316 0.0443731653457423 280 5400454 SGTC_2588 indole-3-carbinol 100 µM 1.70093631374712 0.065966635411895 no 317 0.0444774733737499 389 3712 Induces cell cycle arrest. SGTC_2213 7173844 200 µM 1.6999762915787 0.0660762902248246 no 318 0.0445676925586267 310 892728 SGTC_2881 9058953 51.95 µM 1.69383794725745 0.0667807599351791 no 319 0.0451480405227697 364 17122249 SGTC_2090 5301565 104.445 µM 1.69051277313663 0.0671647941675085 no 320 0.0454649483352895 369 2056344 SGTC_3141 9094609 49.47 µM 1.68822747280034 0.0674297188609688 no 321 0.0456837857152965 340 25236309 YDL196W YDL196W SGTC_1247 0448-0043 5.84 µM 1.68534141280038 0.0677654400876047 no 322 0.0459613600466592 401 3089013 YGL099W LSG1 SGTC_2743 auranofin 4.32 µM 1.6684346379203 0.069758116517807 no 323 0.0476147385030677 309 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_733 4069-0007 56.1 µM 1.65328604386729 0.071581607245086 no 324 0.0491363309823445 428 5717425 YNL287W SEC21 SGTC_1748 st037455 53.6035 µM 1.652625702595 0.0716619189779419 no 325 0.0492035318876632 363 580690 SGTC_136 0097-0015 404.482 µM 1.65017714151184 0.0719603202636612 no 326 0.0494533553175501 377 4861337 SGTC_2752 diclazuril 33.15 µM 1.64640996220963 0.0724212782027403 no 327 0.0498396917089142 517 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1564 D-Arginine 115 µM 1.64162401793302 0.0730101523422864 no 328 0.0503339735017978 360 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.64133780388246 0.0730454846051206 no 329 0.050363656417207 364 2333 A French combination drug. SGTC_827 3253-0474 693 µM 1.63799439887702 0.0734591876970475 no 330 0.0507114311047898 363 5402065 SGTC_1122 capsaicin 818.572 nM 1.63774447864208 0.0734901839228138 no 331 0.0507375039700593 348 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_93 0109-0045 59.227 µM 1.63292387105621 0.0740900160782879 no 332 0.0512425044655845 453 88733 SGTC_3259 9138485 49.47 µM 1.6326461275601 0.0741246895449786 no 333 0.0512717219133516 402 17646153 SGTC_2712 st079126 47.7 µM 1.63245679803684 0.0741483325249467 no 334 0.0512916461783608 329 3152970 SGTC_1440 4100-1550 40 µM 1.6297715835331 0.074484275637745 no 335 0.0515748908554317 283 742806 SGTC_2009 4012297 12.05 µM 1.62246071444087 0.0754048153869301 no 336 0.0523523691293378 373 45595307 SGTC_416 estradiol valerate 100 µM 1.61733117408646 0.076055854240126 no 337 0.0529034067846779 347 13791 A steroid. SGTC_3145 9085516 49.47 µM 1.6149918910436 0.0763541719214948 no 338 0.0531562254652299 355 25236195 SGTC_224 benfluorex 43.875 µM 1.61423078797642 0.0764514235078048 no 339 0.0532386881101497 231 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2035 5154463 94.595 µM 1.61219061402006 0.0767125759857442 no 340 0.0534602335507156 400 2769623 SGTC_374 0880-0231 82.3 µM 1.60829255095869 0.0772134330546137 no 341 0.0538855606660902 369 6833587 SGTC_1452 4194-0072 190 µM 1.60396964923763 0.0777717782543756 no 342 0.0543603714105276 393 1343545 SGTC_2489 cantharidin 73.42 µM 1.60396888416835 0.0777718773410982 no 343 0.0543604557347492 421 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_389 tpck 16.7 µM 1.60311027084124 0.0778831396800084 no 344 0.0544551554131619 340 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_71 0417-1750 47.813 µM 1.59891188926188 0.0784289217542066 no 345 0.0549200909508848 420 6811472 SGTC_2201 6605497 169.863 µM 1.59850414315218 0.0784820821190638 no 346 0.0549654120422682 328 670741 SGTC_1749 st037932 54.2 µM 1.59472223485686 0.0789764551149031 no 347 0.0553871817942141 371 594497 SGTC_2046 4110841 106 µM 1.59047946173093 0.079533876047654 no 348 0.0558633857598684 365 44119630 YMR134W ERG29 SGTC_1155 4088-0394 48.2 µM 1.58813532123055 0.0798431263514219 no 349 0.0561278713878288 382 2326248 SGTC_3113 9123498 49.47 µM 1.58575924110332 0.0801575174996301 no 350 0.0563969674410073 347 8897275 SGTC_724 3910-0327 137 µM 1.58472467703571 0.0802946979458958 no 351 0.0565144512967401 385 2885483 SGTC_125 0133-0007 11.75 µM 1.58260489055004 0.0805763300728783 no 352 0.0567557740647296 365 26541 SGTC_1041 0206-0046 107 µM 1.58115545592538 0.0807693291934749 no 353 0.0569212487133291 371 50494 SGTC_1354 1498-1681 81 µM 1.57769796629279 0.0812311195701067 no 354 0.0573175068694948 407 5754243 SGTC_1056 3448-1962 115 µM 1.57475594725492 0.0816256287974274 no 355 0.0576563941901712 354 715507 SGTC_2972 9093619 59.92 µM 1.57475549378363 0.0816256897166843 no 356 0.0576564465461242 379 25236256 SGTC_310 1273-0058 1.06 µM 1.57448866273469 0.0816615416994093 no 357 0.0576872602588447 654 2734232 SGTC_1893 st059353 36.1 µM 1.56908575080148 0.0823900446342381 no 358 0.0583139797624195 413 3112488 SGTC_1581 himbacine 57.9 µM 1.56377475707346 0.0831109124962121 no 359 0.05893523719705 422 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3103 9120822 49.47 µM 1.56023971568567 0.0835933507288604 no 360 0.0593516217334029 403 17141819 SGTC_3099 9120367 49.47 µM 1.55916519553842 0.0837404100861361 no 361 0.0594786430763389 386 24824940 SGTC_117 lucigenin 22.078 µM 1.55683612999562 0.0840598341702699 no 362 0.0597546983654011 466 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1248 0469-0687 58.6 µM 1.55361543224285 0.0845030487695595 no 363 0.0601380879917746 400 4017482 SGTC_2757 clomiphene 4.22 µM 1.55152558757708 0.0847915780553884 no 364 0.0603878901278874 461 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1886 st057356 49.9 µM 1.54768054421187 0.085324363403062 no 365 0.060849614289181 371 24207747 SGTC_1523 st012844 44.7 µM 1.54732519120764 0.0853737289224184 no 366 0.0608924250967866 415 4274103 SGTC_1704 st028805 70.8 µM 1.54619683605256 0.0855306214606549 no 367 0.0610285187071317 374 2876101 SGTC_1059 3448-6867 171 µM 1.54569578213814 0.0856003598649035 no 368 0.0610890281960852 386 3934407 SGTC_2466 5983409 37.09 µM 1.54221414197059 0.0860861227230002 no 369 0.0615107823107462 395 2879657 SGTC_1029 k015-0030 64.7 µM 1.53249198209059 0.0874534879276783 no 370 0.0627005373320885 403 2208316 SGTC_1628 st004252 77.7 µM 1.53077032387982 0.0876973093661837 no 371 0.0629130832012683 418 692968 SGTC_1275 0867-0008 21.1 µM 1.5282367113566 0.0880570416686577 no 372 0.0632268885100562 420 3422836 SGTC_790 1575-0012 79.1 µM 1.52597456855011 0.0883791583015402 no 373 0.0635080990722999 417 378741 YLR208W SEC13 SGTC_763 3453-1109 128 µM 1.52155682968439 0.0890107502454941 no 374 0.0640600807560647 422 1560353 SGTC_990 3985-0011 41.3 µM 1.52103874587087 0.089085038810293 no 375 0.0641250572149487 363 5399565 YGL099W LSG1 SGTC_1230 0170-0365 3.77 µM 1.51721455944129 0.0896348207403944 no 376 0.0646062607814486 565 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2648 atorvastatin 78.68 µM 1.51540428924734 0.0898959512470877 no 377 0.0648350259243775 372 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_588 3970-1144 52.9 µM 1.51336136660989 0.090191320317953 no 378 0.0650939463413003 432 1888707 SGTC_2397 5161689 200 µM 1.51195543465585 0.090395010617594 no 379 0.0652726000830331 439 2259942 SGTC_768 0384-0033 77.3 µM 1.51021559294542 0.0906475501688484 no 380 0.0654942105817667 502 3965305 YMR134W ERG29 SGTC_1633 st005664 67.9 µM 1.50934495735118 0.0907741201090957 no 381 0.0656053257017227 441 2063822 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.50419131718186 0.0915260249850053 no 382 0.0662660563964681 425 115019 SGTC_1860 st056228 74.6 µM 1.50112762178928 0.0919751935729342 no 383 0.0666612778814104 391 688679 SGTC_1468 k284-1086 134 µM 1.50068769661228 0.0920398248281694 no 384 0.0667181783875515 500 15996457 SGTC_2283 7944793 200 µM 1.49997188532725 0.0921450595348988 no 385 0.0668108426904572 437 2970533 SGTC_2072 5231554 129 µM 1.49708181933699 0.0925708473108196 no 386 0.0671859848895034 400 789545 SGTC_187 1488-2104 32.728 µM 1.49264438753366 0.0932274358006631 no 387 0.0677651488962722 445 2852859 SGTC_1979 st071809 45.3 µM 1.48941807668859 0.0937069758127252 no 388 0.068188655683284 417 4976333 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.48566183132947 0.094267573681662 no 389 0.0686842956478026 448 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1394 3474-0001 65.7 µM 1.48033892104351 0.0950662180447496 no 390 0.0693914106421038 379 5017666 YIL048W NEO1 SGTC_2315 7733312 200 µM 1.47483614781198 0.0958970764556644 no 391 0.0701283001553825 395 726316 SGTC_2476 5806916 10.51 µM 1.47478330571954 0.0959050808392584 no 392 0.0701354054319055 396 2870194 SGTC_577 r071-0003 38.6 µM 1.47354299096274 0.0960931016640948 no 393 0.0703023402642112 577 4568517 YMR134W ERG29 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.47156714776137 0.096393181663887 no 394 0.0705689012252562 421 2724278 An inhibitor of dopamine biosynthesis. SGTC_2431 5490079 200 µM 1.4703694211841 0.0965754205861838 no 395 0.0707308642730791 445 5722345 SGTC_2705 st078069 42.8 µM 1.46891972268331 0.0967963364679359 no 396 0.0709272822389701 408 1530061 SGTC_3115 9123671 49.47 µM 1.4682536616803 0.0968979601414926 no 397 0.0710176664246026 403 3286988 SGTC_250 brefeldin a 552.239 µM 1.46711415721621 0.0970720006415598 no 398 0.0711725017703009 362 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1384 3089-0840 101 µM 1.46420519303391 0.0975173371888205 no 399 0.0715689458814592 390 1069836 SGTC_2254 7938975 95.19 µM 1.46223687989923 0.0978195172153751 no 400 0.071838154315773 545 2969277 SGTC_1312 1218-2183 165 µM 1.45902803762663 0.0983136168312477 no 401 0.07227869546314 450 6744073 SGTC_2357 9067248 200 µM 1.45816889989865 0.0984462171000132 no 402 0.0723969969097601 412 9150235 SGTC_1057 3448-5381 134 µM 1.45450841943007 0.0990126473879872 no 403 0.0729027004658794 470 5497911 SGTC_2232 chlorophetanol 41.5365 µM 1.45136832104639 0.0995004493216716 no 404 0.0733386630311498 594 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1000 4048-0884 8.67 µM 1.44516884385427 0.100468666337653 no 405 0.0742052327138156 456 13040088 SGTC_1066 ketoconazole 628 nM 1.44404347705365 0.100645157686962 no 406 0.0743633729723089 486 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1943 st076331 65.2 µM 1.44209679704334 0.100950989392838 no 407 0.0746375342585797 451 24208415 SGTC_748 act1.228 77.9 µM 1.44070078050717 0.101170726288507 no 408 0.074834617157871 521 4421505 YNR035C ARC35 SGTC_211 3455-0679 143.504 µM 1.44051606465802 0.101199827169062 no 409 0.074860724167554 479 748649 SGTC_1849 st056239 19.2 µM 1.43755744483507 0.101666771635505 no 410 0.0752798313234179 476 5393181 SGTC_1291 0993-0025 5.79 µM 1.43569688425838 0.101961217103911 no 411 0.0755443061099959 445 4353356 SGTC_3248 9135562 49.47 µM 1.43471255176953 0.102117244722512 no 412 0.0756845129769957 473 17650701 SGTC_2233 sulbentine 40.3845 µM 1.43381140592351 0.102260238578853 no 413 0.0758130445921452 512 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_986 1493-0483 84 µM 1.43309240011142 0.102374434864903 no 414 0.0759157165213669 427 40079 SGTC_2203 7227154 166.4 µM 1.43203452761849 0.1025426202945 no 415 0.076066970070948 412 896304 SGTC_2339 9000433 200 µM 1.42951816782148 0.102943489728792 no 416 0.0764276784709303 419 2988954 SGTC_2691 st077356 60.2 µM 1.42655454508514 0.103417069049569 no 417 0.0768541670660065 474 2839272 SGTC_1026 k007-1105 30.6 µM 1.42362347241719 0.103887000461745 no 418 0.0772777486880726 561 7066794 SGTC_390 dec-rvkr-cmk 16.7 µM 1.42349513234932 0.10390761223158 no 419 0.0772963360976095 487 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2313 7726885 200 µM 1.41750238873486 0.10487336853834 no 420 0.0781680482284156 467 726423 SGTC_3335 9143315 29.6265 µM 1.41179895756976 0.105798521115135 no 421 0.079004582752657 460 4899691 SGTC_1662 st014054 52 µM 1.40801069057309 0.106416267024823 no 422 0.0795639522141254 413 2838777 SGTC_3282 9108498 15.4605 µM 1.40667423851388 0.10663482014182 no 423 0.079762004050846 498 16459645 SGTC_2239 6685329 187.64 µM 1.40487370499357 0.106929777580347 no 424 0.0800294184919861 491 805680 SGTC_861 0443-0273 110 µM 1.40267391271569 0.107290938509467 no 425 0.0803570499670282 473 6149169 SGTC_2451 5856223 45.7 µM 1.39974936969428 0.107772449336887 no 426 0.0807941920582844 470 2179896 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.39567704267627 0.108445526881791 no 427 0.0814058852807188 539 676296 Flavone; oxidizing agent. SGTC_2575 plumbagin 510 nM 1.39426583817059 0.108679476083665 no 428 0.0816186714504604 475 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1457 k015-0032 57.3 µM 1.39197140297185 0.109060621535832 no 429 0.0819655289110329 494 4302660 SGTC_1618 st003135 44.5 µM 1.39070026786262 0.109272192194193 no 430 0.0821581681850269 467 1270615 SGTC_3091 9116372 49.47 µM 1.38658477985112 0.109959205928663 no 431 0.0827842060095266 449 17169793 SGTC_2841 9004761 38.96 µM 1.38455519874438 0.110299150298401 no 432 0.0830942593120822 436 2991039 SGTC_1664 st014217 9.02 µM 1.38440920908547 0.110323631837541 no 433 0.083116595357745 501 3982782 SGTC_1966 st070145 16.1 µM 1.38397564047739 0.110396361510782 no 434 0.0831829568656869 481 3748532 SGTC_1745 st081495 74 µM 1.38313130906866 0.110538093907211 no 435 0.0833123035748628 553 13842402 YBL026W LSM2 SGTC_3053 9095903 49.47 µM 1.38254360875574 0.110636824281471 no 436 0.0834024250881287 461 17174018 SGTC_2330 7979373 200 µM 1.38061534931283 0.110961204943065 no 437 0.08369863065948 506 1863007 SGTC_958 1222-0007 33 µM 1.37948713824095 0.111151313401194 no 438 0.0838723045471783 541 7312461 SGTC_1390 3413-2614 145 µM 1.3786201762325 0.111297558647315 no 439 0.0840059462229084 518 3421432 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.37621263956761 0.11170440110457 no 440 0.0843779050157181 554 6708784 An antioxidant flavonoid SGTC_1313 1220-0047 237 µM 1.37240276426971 0.112350392552739 no 441 0.0849690450369424 549 3528706 SGTC_1037 k284-1091 78.7 µM 1.36896430560773 0.112935695489433 no 442 0.0855052163960496 431 3334711 SGTC_197 4544-0043 41.561 µM 1.36716266072351 0.113243243462301 no 443 0.0857871631081388 541 896523 SGTC_89 0302-0250 142.109 µM 1.365121424276 0.113592412084493 no 444 0.0861074446995514 541 4203518 YLR208W SEC13 SGTC_177 1327-0068 8.361 µM 1.36296330624827 0.113962408205653 no 445 0.0864470376460268 524 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_793 0488-0545 106 µM 1.35901464181034 0.114641603741883 no 446 0.0870709745267246 514 292548 SGTC_2240 6690706 185.951 µM 1.35773840292587 0.114861739730015 no 447 0.0872733532471825 419 805876 SGTC_2855 9016525 58.44 µM 1.3523661580622 0.115791684471442 no 448 0.0881291049514527 501 43811474 SGTC_233 rapamycin 362 pM 1.34631395544234 0.116845721425076 no 449 0.0891006435308278 507 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1769 st044406 64.4 µM 1.34503507630682 0.117069315598345 no 450 0.089306953732315 563 670903 SGTC_625 k213-0058 121 µM 1.34208368510818 0.117586481874199 no 451 0.0897844315889034 707 3655420 SGTC_172 1112-0046 2.638 µM 1.34064623892961 0.117838947463404 no 452 0.0900176685380424 458 2802135 YIL048W NEO1 SGTC_782 0083-0095 30.5 µM 1.32496533317437 0.120617994298936 no 453 0.0925913248246839 577 3591729 An indicator and reagent. SGTC_1731 st035964 63 µM 1.32466966172424 0.12067083417444 no 454 0.092640369893192 523 6739575 SGTC_2139 5578692 56.4705 µM 1.32455707232958 0.120690959472731 no 455 0.0926590509257322 462 650991 YMR113W FOL3 SGTC_2259 7964009 200 µM 1.32118432912705 0.121294931499447 no 456 0.0932199550984182 493 313134 SGTC_2658 polymyxin b sulfate 77.05 µM 1.32046206941885 0.121424545568572 no 457 0.0933403960135674 551 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1813 st051246 8.6015 µM 1.31927311500968 0.121638122975092 no 458 0.0935389112454529 486 5291959 SGTC_1240 0356-0016 42.1 µM 1.31548116914051 0.122321051060818 no 459 0.0941741209758628 538 4305613 SGTC_1497 4476-2978 41.3 µM 1.31014272220634 0.123287058009196 no 460 0.0950737790530432 585 1528379 SGTC_1666 st014829 29 µM 1.30801555633391 0.123673460050999 no 461 0.0954340164684374 568 3858230 SGTC_287 k060-0039 29.6 µM 1.30748995412518 0.123769066784658 no 462 0.0955231822641605 525 5861974 SGTC_2144 5628481 200 µM 1.30641357729329 0.123965020552282 no 463 0.0957059755514912 481 2818399 SGTC_728 3030-5151 22.5 µM 1.30183696661491 0.124800613516504 no 464 0.0964860619590524 506 3125388 SGTC_160 3453-0671 289.699 µM 1.29681195099829 0.125722599867523 no 465 0.0973479488171887 560 5322268 SGTC_1364 1653-0028 37.6 µM 1.29411693128189 0.126219033058732 no 466 0.0978125170358345 563 5718652 SGTC_1622 st003707 19.4 µM 1.29409401221263 0.126223260691688 no 467 0.0978164747881371 590 10140899 SGTC_2731 amoxapine 43.43 µM 1.29307266661125 0.126411757476487 no 468 0.097992963835875 409 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2399 5884133 200 µM 1.29291008048292 0.126441782019229 no 469 0.098021080319306 542 722445 SGTC_1483 3453-0561 55.9 µM 1.29177945693256 0.12665071002344 no 470 0.0982167657796249 607 4546991 SGTC_1933 st074711 15.9 µM 1.29033613173404 0.126917771387316 no 471 0.0984669884759642 592 17250958 SGTC_334 1502-1024 68.5 µM 1.2881247277914 0.127327711877798 no 472 0.0988512744164535 570 3296216 SGTC_2954 9074818 52.69 µM 1.28776267889175 0.127394914573964 no 473 0.0989142937312531 550 16648742 SGTC_1104 tacrolimus 29.8 µM 1.28576658143872 0.127765868570401 no 474 0.0992622682478014 602 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1707 st032323 6.317 µM 1.27951757168881 0.128932033464426 no 475 0.100357427928146 595 3132057 YMR211W DML1 SGTC_901 1112-0062 60.1 µM 1.27784125742007 0.129246112272901 no 476 0.1006527019442 536 1908457 SGTC_2318 6029776 164 µM 1.2755869539649 0.129669320256221 no 477 0.101050784122264 578 818325 SGTC_2923 7992654 58.14 µM 1.2748960084732 0.12979922574029 no 478 0.101173026038217 554 2985126 SGTC_2662 daunorubicin 22.37 µM 1.27340531041122 0.130079800526155 no 479 0.10143712697338 521 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1995 st072814 61.1 µM 1.27226591015303 0.130294537910463 no 480 0.101639328239561 540 5769371 SGTC_1961 st076550 68.7 µM 1.27110977010876 0.130512680712604 no 481 0.101844800020866 510 1579337 SGTC_560 2332-1943 155 µM 1.27103288107365 0.130527197240363 no 482 0.101858475625878 558 21177716 SGTC_2488 5268135 45.7 µM 1.2706957419548 0.130590861752005 no 483 0.1019184555004 668 1270356 YLR208W SEC13 SGTC_3337 9144342 33.5465 µM 1.26935513126061 0.130844231759358 no 484 0.102157215709469 565 17682949 SGTC_338 4055-0136 114 µM 1.26844312979404 0.131016790410758 no 485 0.102319873831022 565 2900563 SGTC_49 0717-0965 32.132 µM 1.26694209952355 0.131301140687009 no 486 0.102587996940689 577 5889349 YGL099W LSG1 SGTC_2774 tamoxifen 10.92 µM 1.26507934353861 0.13165460730379 no 487 0.102921443417388 548 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2104 5389443 200 µM 1.26444462662692 0.131775197650503 no 488 0.103035241893256 633 2244536 SGTC_3116 9124943 49.47 µM 1.26396614940763 0.131866154263735 no 489 0.103121088532704 520 41905195 YPL160W CDC60 SGTC_1506 4226-2149 212 µM 1.26326782167698 0.131998981298167 no 490 0.103246473163164 628 991114 SGTC_2447 5741742 33.78 µM 1.26257742998691 0.132130389518075 no 491 0.103370541659448 593 1776504 SGTC_675 1309-0189 238 µM 1.25993440372524 0.132634293047548 no 492 0.103846513286639 574 4246530 SGTC_2236 dapsone 200 µM 1.25939182701769 0.132737901024593 no 493 0.103944420023778 594 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2008 4012253 172 µM 1.25716900884918 0.1331629421327 no 494 0.104346221407777 590 603940 SGTC_1425 4048-4433 7.33 µM 1.25232087071317 0.134093236224315 no 495 0.10522648343214 619 23734946 SGTC_3169 9102970 49.47 µM 1.24645812652054 0.135224171675023 no 496 0.106298126445006 572 17027839 SGTC_37 0566-0070 1.56 µM 1.24390253754442 0.135719190762433 no 497 0.106767717669927 639 1626686 SGTC_505 gw-5074 63.9 µM 1.24335659925335 0.135825100026902 no 498 0.106868227966048 589 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2903 5923464 63.88 µM 1.24283723921982 0.135925905762912 no 499 0.106963908401996 563 2876576 SGTC_785 1270-0111 65.3 µM 1.2373876764294 0.136986733235101 no 500 0.107971595861805 579 6741994 SGTC_823 0417-1665 178 µM 1.23733722861616 0.136996579906815 no 501 0.107980956073883 587 3429856 SGTC_3120 9124077 49.47 µM 1.2363386171904 0.137191593726835 no 502 0.108166361182036 598 18774327 YGL155W CDC43 SGTC_464 bw-b 70c 158 µM 1.23620066338241 0.137218548934454 no 503 0.108191992092419 639 5353454 SGTC_1683 st010134 710 nM 1.22904893828019 0.138620902272046 no 504 0.109526729033361 600 3818134 SGTC_2939 9044578 71.43 µM 1.22903818554214 0.138623018058354 no 505 0.109528744695714 581 2653634 SGTC_1171 0368-0077 21.4 µM 1.22900880087874 0.13862880010891 no 506 0.109534253155086 558 3239779 SGTC_3112 9123419 49.47 µM 1.22289466289324 0.139835460091652 no 507 0.110684742325764 626 17015854 SGTC_3077 9117319 49.47 µM 1.21311673952847 0.141779988284212 no 508 0.112542595429085 539 17154678 SGTC_497 capsazepine 133 µM 1.21104905203915 0.142193522270044 no 509 0.112938302882445 587 2733484 A calcium channel blocker. SGTC_1090 efavirenz 20.7 µM 1.21019984764352 0.142363597931013 no 510 0.113101108279999 605 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_140 0062-0056 502.533 µM 1.20846008775815 0.142712460528445 no 511 0.113435169552082 645 3758964 SGTC_1962 st076595 64.5 µM 1.20674470555006 0.143057000254478 no 512 0.113765238295255 616 279619 SGTC_995 3931-2021 34.6 µM 1.20495968717295 0.143416122821881 no 513 0.114109432400203 587 730143 SGTC_478 N-arachidonylglycine 10 µM 1.20359262644049 0.143691568971923 no 514 0.114373535414898 472 5283389 SGTC_315 k915-0449 187 µM 1.20219774604935 0.143972988185196 no 515 0.114643461196416 711 20970215 YNL149C PGA2 SGTC_305 1682-2595 20.8 µM 1.20112169919634 0.14419033608222 no 516 0.114851998455766 633 226033 SGTC_2860 9025725 38.96 µM 1.20059316843857 0.144297173601962 no 517 0.114954526174185 559 40546248 SGTC_2802 7925815 54.55 µM 1.19940569852756 0.144537404043197 no 518 0.115185116434337 630 1262923 SGTC_1199 1638-0010 4.46 µM 1.19756744166875 0.144909822741204 no 519 0.115542728770969 660 3111136 SGTC_3065 9113888 49.47 µM 1.19349567409237 0.145737034592152 no 520 0.116337652672334 577 16648368 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.19282691207292 0.145873201789688 no 521 0.116468583979132 565 15053 SGTC_2129 girgensonine 121.053 µM 1.19127568700255 0.146189377113393 no 522 0.116772687637379 675 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2836 9010338 19.48 µM 1.19031925910604 0.146384548315767 no 523 0.116960466982101 567 2994051 SGTC_1857 st056007 79.3 µM 1.18565021033512 0.147339837482545 no 524 0.117880232362338 597 619834 SGTC_1789 tunicamycin 25 nM 1.18544698775781 0.147381511565186 no 525 0.117920381483267 635 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_941 3237-0776 460 µM 1.18523525664062 0.147424938862886 no 526 0.117962221860429 600 760008 SGTC_3182 9108849 49.47 µM 1.18446472384951 0.14758305204548 no 527 0.118114576192371 649 17133045 SGTC_1106 tegaserod maleate 11.7 µM 1.18227949185883 0.148032078924178 no 528 0.118547410091554 663 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_914 3820-6779 408 µM 1.18103709966787 0.148287776035847 no 529 0.118793992762089 592 2893481 SGTC_897 1000-0139 31.4 µM 1.18042420055337 0.148414025754562 no 530 0.118915770721858 635 6151020 SGTC_808 0711-0032 135 µM 1.17987540194147 0.148527132539835 no 531 0.119024887235314 636 4252555 SGTC_1659 st012954 42.1 µM 1.17867386217735 0.148774969743614 no 532 0.119264033729708 620 24207262 SGTC_2049 5262831 67.185 µM 1.17814921092254 0.148883274277944 no 533 0.119368563128691 634 763417 SGTC_1299 1079-1439 3.74 µM 1.17480299701246 0.149575277493011 no 534 0.120036770421507 609 323161 SGTC_3197 9113331 49.47 µM 1.17412287413237 0.149716190200783 no 535 0.120172906282973 637 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2346 9031566 143.75 µM 1.16923183564843 0.150732158397407 no 536 0.121155118955058 651 4771086 SGTC_2178 5812956 200 µM 1.16727568543425 0.151139772738072 no 537 0.121549527285656 616 5403383 SGTC_1591 genipin 88.4 µM 1.16648191046626 0.151305385202251 no 538 0.121709829106286 613 442424 A DNA cross-linking agent. SGTC_395 anisomycin 6.25 µM 1.16555708408811 0.151498492287653 no 539 0.121896783885681 568 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1597 7-benzyloxygramine 47.5 µM 1.16331308406877 0.151967728466429 no 540 0.122351249513417 762 260807 SGTC_1463 k081-0032 34.1 µM 1.16087493300613 0.152478656178558 no 541 0.122846382101339 531 977755 SGTC_970 1315-0089 19.5 µM 1.15690799661773 0.153312382578335 no 542 0.123654975637494 615 6811083 YLR033W RSC58 SGTC_95 0471-0001 561.058 µM 1.15266461834891 0.154207545644433 no 543 0.124524034623987 643 4015405 SGTC_1159 4092-0538 61.2 µM 1.15133471714088 0.154488805385666 no 544 0.12479727989281 701 717301 SGTC_422 cantharidin 155 µM 1.14961777912755 0.154852420418369 no 545 0.125150666077405 655 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3346 9158254 43.5805 µM 1.14845222993393 0.155099583609942 no 546 0.125390961340447 659 17639500 SGTC_2561 acetosyringone 100 µM 1.14738505342493 0.155326114455162 no 547 0.125611257878948 755 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2168 5727979 200 µM 1.14659930550668 0.155493045616265 no 548 0.125773631822919 600 695210 SGTC_1092 toremifene 6.32 µM 1.14554686831062 0.155716819949058 no 549 0.125991346114377 708 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1423 4048-0112 5.59 µM 1.14401979436477 0.156041891313647 no 550 0.126307714018123 665 X1423 SGTC_2012 4023501 200 µM 1.13796877052271 0.157334379314925 no 551 0.127566761462921 620 3477460 SGTC_368 fentichlor 4.58 µM 1.13404217505259 0.158176847654006 no 552 0.12838842868449 592 7329 A pesticide. SGTC_2155 5570423 76 µM 1.13332061493955 0.158331982972592 no 553 0.128539818854529 653 797402 SGTC_2156 5649887 115 µM 1.12952224369749 0.159150277565485 no 554 0.129338795761668 764 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_447 ml7 120 µM 1.1289577884527 0.159272115869411 no 555 0.129457820464813 686 4216 Selective myosin light chain kinase inhibitor. SGTC_529 4076-0302 30.3 µM 1.12635328170025 0.159835092577113 no 556 0.130008006590028 681 5816522 SGTC_1213 1315-0166 115 µM 1.12586520230303 0.159940737948568 no 557 0.130111290184472 579 768401 SGTC_3088 9117578 49.47 µM 1.12534965629593 0.160052378085851 no 558 0.130220447704217 664 678341 SGTC_2869 9037858 32.47 µM 1.12515023860397 0.160095575128031 no 559 0.130262687775403 633 27187042 SGTC_18 0111-0177 500 nM 1.12451354392249 0.160233544333238 no 560 0.130397614022751 788 721752 SGTC_355 1311-2252 105 µM 1.12437457575714 0.160263668511848 no 561 0.130427076548015 674 5338538 SGTC_1307 1187-1599 12.2 µM 1.12429977782741 0.160279884017935 no 562 0.130442936300827 687 1538471 SGTC_2943 9068529 45.32 µM 1.12384372832718 0.160378774572518 no 563 0.130539663455132 730 3270634 SGTC_2771 fluoxetine 41.05 µM 1.12086313666396 0.161026072772631 no 564 0.131173062137403 648 3386 A selective serotonin reuptake inhibitor. SGTC_1900 st060200 72.8 µM 1.11892035274643 0.161448905767924 no 565 0.131587059655673 689 688945 SGTC_1819 st053448 58.6 µM 1.11750041197106 0.161758403241933 no 566 0.131890211768013 688 2857616 SGTC_336 4111-0029 111 µM 1.11574050110655 0.162142538545193 no 567 0.13226661436915 629 3131175 SGTC_1392 3455-1037 33.9 µM 1.11319161696346 0.162699935144771 no 568 0.13281307113056 689 981132 SGTC_2456 5770359 74.46 µM 1.11222718971425 0.162911163235187 no 569 0.133020240106442 721 3118787 SGTC_1734 st037168 69.4 µM 1.11205338855378 0.162949247980349 no 570 0.133057598041695 682 708907 SGTC_1034 k072-0165 12.7 µM 1.11096895938096 0.16318700777502 no 571 0.133290855298966 741 5835461 SGTC_1637 st007924 17.4 µM 1.11044529407986 0.163301901439437 no 572 0.133403594709112 687 683336 SGTC_3245 9134821 49.47 µM 1.10999226154387 0.163401340462558 no 573 0.133501180563441 699 17014901 SGTC_3348 9149464 3.537 µM 1.10870485708951 0.163684135789839 no 574 0.133778762953234 701 1951442 SGTC_2569 tetrandrine 100 µM 1.10844670855505 0.163740879732701 no 575 0.133834471103941 611 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_563 tetrahydrosecaminediol 614 µM 1.10749931477573 0.163949236916798 no 576 0.13403905419423 730 334274 A psychoactive constituent of the cannabis plant. SGTC_3246 9135460 32.98 µM 1.10745305148357 0.163959415853306 no 577 0.134049049929603 615 41446951 SGTC_1901 st060216 58.6 µM 1.10620453827034 0.164234270923572 no 578 0.134318999505002 699 688792 SGTC_1964 st076914 61 µM 1.10464705099416 0.164577563976439 no 579 0.134656277491731 708 24208661 SGTC_1349 flufenamic acid 69 µM 1.10460102242781 0.164587716417301 no 580 0.13466625393406 677 3371 A non-steroidal anti-inflammatory. SGTC_1807 st050092 58.9 µM 1.10442763252889 0.164625964369766 no 581 0.134703839809509 674 5008496 SGTC_2173 5763948 167 µM 1.10140510194969 0.165293627356302 no 582 0.1353601929659 722 2867177 SGTC_692 k241-0027 77.8 µM 1.10021877778167 0.165556159034244 no 583 0.135618405465247 689 3600480 SGTC_1850 st056238 17 µM 1.10008227559207 0.165586384046054 no 584 0.135648137840615 750 5393177 SGTC_251 melphalan 456.522 µM 1.09959414822777 0.165694496895777 no 585 0.13575449637504 794 460612 A DNA alkylator. SGTC_557 1315-0110 16.2 µM 1.09828717568205 0.165984196257534 no 586 0.136039555011242 708 6833801 SGTC_1766 st045414 44.774 µM 1.09804796184935 0.166037255047222 no 587 0.136091773327115 763 253960 SGTC_932 2857-0803 154 µM 1.09531495068786 0.166644227928818 no 588 0.136689339896927 758 674898 SGTC_662 k832-1615 104 µM 1.09391891403478 0.166954824756063 no 589 0.136995271301068 695 5878478 SGTC_1118 chelidonine 707.474 nM 1.09312932707422 0.167130660990114 no 590 0.137168510613034 771 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1669 st015249 58.4 µM 1.09160385551596 0.167470712303394 no 591 0.137503630373014 719 722793 SGTC_3250 9135583 49.47 µM 1.0905334740415 0.167709582906263 no 592 0.137739108126121 685 7699353 SGTC_2956 9076196 2.52 µM 1.09012524297642 0.167800743149828 no 593 0.137828989053316 707 16423868 SGTC_202 3594-0513 34.79 µM 1.08808730201112 0.168256303652891 no 594 0.13827828442237 685 708429 SGTC_1481 3346-2004 36 µM 1.08773268959905 0.168335654756533 no 595 0.138356566038227 737 2770522 SGTC_2247 cerulenin 830 nM 1.08756102981807 0.168374075460295 no 596 0.138394471231247 718 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2649 anisomycin 9.56 µM 1.08678848225844 0.16854705600276 no 597 0.138565149543341 696 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_868 0527-0199 213 µM 1.08669980296336 0.168566919424388 no 598 0.13858475056101 742 2849450 SGTC_886 0866-0150 153 µM 1.08596940284315 0.16873058019187 no 599 0.138746264674671 759 271463 SGTC_2391 6285546 200 µM 1.08352446191078 0.169279160879579 no 600 0.139287849552668 737 846083 SGTC_1771 st048882 4.1505 µM 1.07949115715565 0.170186628047412 no 601 0.140184416860016 710 4580403 SGTC_1665 st014639 11.4 µM 1.07936843892238 0.170214287622097 no 602 0.14021175733115 773 981133 YIL048W NEO1 SGTC_1252 0493-0875 34.8 µM 1.07933133788029 0.170222650426855 no 603 0.140220023808258 690 3960963 SGTC_2334 9017922 200 µM 1.07874268538267 0.170355371569279 no 604 0.140351225668543 750 3163164 SGTC_26 0302-0163 425.158 µM 1.07734482042131 0.170670808148267 no 605 0.14066312286575 734 3100915 SGTC_2549 cedrol 20.94 µM 1.07686957283622 0.170778135715191 no 606 0.140769269068157 667 6708665 A sedative which affects the nervous system. SGTC_2304 7443016 91.4 µM 1.07395677910421 0.171436890060715 no 607 0.141421026670714 668 939854 SGTC_2062 5245942 200 µM 1.07088467428958 0.172133431318561 no 608 0.142110643850223 759 1376160 SGTC_1357 1503-1303 39.5 µM 1.06806840087 0.172773552197666 no 609 0.142744829217861 769 292895 SGTC_1264 0783-0040 158 µM 1.0657328379185 0.173305560040802 no 610 0.143272214446775 696 2855798 SGTC_2056 5235370 200 µM 1.06482747199385 0.173512069677505 no 611 0.143477005409677 700 5511916 SGTC_3215 9129942 49.47 µM 1.06443874952892 0.173600783447651 no 612 0.143564993834399 693 17682944 SGTC_1616 st002734 56.1 µM 1.06389128024427 0.173725775163416 no 613 0.143688976806948 769 4026101 SGTC_1479 0549-0158 134 µM 1.06360560608439 0.173791019635556 no 614 0.143753700863694 795 5440202 SGTC_21 0849-0113 22.993 µM 1.06159339251454 0.174251025952884 no 615 0.144210157322158 754 1560156 SGTC_1309 pyrazolanthrone 13.4 µM 1.05990557845145 0.174637468347719 no 616 0.144593778773694 791 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_500 h-89 112 µM 1.05436484713944 0.175909897488217 no 617 0.145857954975152 804 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3229 9132204 49.47 µM 1.05271289824123 0.176290400972439 no 618 0.146236297683788 724 17682924 SGTC_853 0419-0306 21 µM 1.05229732716649 0.176386203926354 no 619 0.146331578798038 686 762713 SGTC_572 0960-0087 17.7 µM 1.05210882675074 0.176429670398144 no 620 0.146374811449118 798 6796365 SGTC_1908 st060353 56.5 µM 1.0508007341479 0.176731491228412 no 621 0.146675059276062 813 4227716 SGTC_1333 1482-0047 286 µM 1.04987331900875 0.176945674638235 no 622 0.14688818001017 792 3811116 SGTC_1015 4130-4525 82 µM 1.04943968226463 0.177045877842649 no 623 0.146987901307812 751 1363237 SGTC_1064 honokiol 6.76 µM 1.0488994986878 0.177170751638123 no 624 0.147112188144342 757 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.04656433318817 0.177711209774542 no 625 0.147650279553132 718 6708514 SGTC_1005 4092-0690 4.4 µM 1.04533583736404 0.177995953867727 no 626 0.147933889955883 698 1529343 SGTC_1407 3909-7909 12.3 µM 1.04344929930454 0.178433780527399 no 627 0.148370125473586 792 4411780 SGTC_1773 st048542 73.5835 µM 1.04296584587051 0.178546089237724 no 628 0.148482055671934 735 3237138 SGTC_1471 k673-0312 37 µM 1.04263434230561 0.178623124939946 no 629 0.148558838729599 751 24099884 SGTC_2387 9077560 195.08 µM 1.04111762323473 0.178975851150995 no 630 0.14891048067881 751 5303272 SGTC_1777 st045864 34.765 µM 1.04008338181849 0.179216624146812 no 631 0.149150581824121 782 4691462 SGTC_1999 st074831 12.5 µM 1.03998939140462 0.179238515353683 no 632 0.149172414689506 763 17112523 SGTC_3283 9109332 35.8195 µM 1.03634864988683 0.180087770498772 no 633 0.150019758650609 678 17027281 SGTC_1283 0922-0125 16.4 µM 1.03537743909965 0.180314745477027 no 634 0.150246338829619 814 3360884 SGTC_506 n9-isopropylolomoucine 153 µM 1.03537373169126 0.180315612253673 no 635 0.150247204192151 782 6610355 SGTC_55 0767-0285 6.563 µM 1.03478303822592 0.180453747319314 no 636 0.150385122984127 797 3116166 SGTC_1223 0764-0573 147 µM 1.03326752514452 0.180808457188401 no 637 0.150739360153944 789 1609797 SGTC_540 1187-0821 17.3 µM 1.03187550719582 0.181134647507236 no 638 0.15106522060945 753 847520 SGTC_1750 st081859 2.357 µM 1.03116876125189 0.181300399652272 no 639 0.151230843551108 921 5291695 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.02951190498308 0.181689352042401 no 640 0.151619594204664 752 5355888 SGTC_2931 9014674 55.67 µM 1.02710013374709 0.182256455507767 no 641 0.152186657854827 742 2996810 SGTC_326 k292-0812 17.5 µM 1.02551291113553 0.182630277640548 no 642 0.152560618257277 770 3579357 SGTC_1428 4049-0204 61.7 µM 1.02480457461687 0.182797259220888 no 643 0.152727703736555 813 X1428 SGTC_576 1073-0113 22.7 µM 1.02429710215036 0.182916948161146 no 644 0.152847483136044 960 5439563 SGTC_708 3448-5400 146 µM 1.01765032871713 0.184489122662876 no 645 0.15442208022014 778 3462195 SGTC_366 0181-0206 4.31 µM 1.01281934171655 0.185637063559593 no 646 0.155573230177958 815 274874 SGTC_2419 paclitaxel 166.5 µM 1.01061672461332 0.186161918011244 no 647 0.156099953975053 811 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2964 9083345 53.42 µM 1.00623314044801 0.187209201204403 no 648 0.157151716918939 727 17741579 SGTC_975 1335-0046 28.5 µM 1.00403113065001 0.187736655931554 no 649 0.157681804335992 787 16486740 SGTC_720 r052-1644 49.9 µM 1.0009591750138 0.188474023465944 no 650 0.158423272966966 714 1422863 YOR257W CDC31 SGTC_2805 7950783 58.44 µM 0.999007344005801 0.188943451888772 no 651 0.158895566836405 844 1178958 YDL195W SEC31 SGTC_3268 9137683 49.47 µM 0.996735745282303 0.189490692696816 no 652 0.159446397150674 787 1953228 SGTC_2999 9069765 71.4286 µM 0.994637494556262 0.189997038570759 no 653 0.159956302353515 820 2097066 SGTC_166 k072-0058 166.424 µM 0.993345549792774 0.190309221514913 no 654 0.160270793468215 815 5846229 SGTC_2793 7325131 81.82 µM 0.99226382174251 0.190570850314499 no 655 0.160534423303987 778 4176441 SGTC_1419 3993-2473 62.6 µM 0.991108803568924 0.190850448827404 no 656 0.160816227348577 823 704026 SGTC_1202 1988-0068 29.6 µM 0.989768273581804 0.191175270090208 no 657 0.161143697707393 808 2850480 SGTC_1926 methyl fluorone black 53.6 µM 0.989650189575589 0.191203899034703 no 658 0.161172564606339 728 72721 Reacts with homocysteine. SGTC_2784 7567673 72.73 µM 0.987417391386793 0.191745725669253 no 659 0.161719030996542 836 3471247 SGTC_426 0988-0037 14.6 µM 0.987222476616885 0.191793069647373 no 660 0.161766792670906 863 5383008 SGTC_1705 st027868 56.3335 µM 0.987060584956513 0.191832397891652 no 661 0.161806469390768 825 292948 SGTC_547 1120-0019 610 nM 0.985270304150802 0.192267638857517 no 662 0.162245657616916 802 3676939 SGTC_1350 1495-0454 146 µM 0.983065207214453 0.19280455649094 no 663 0.162787673401436 862 1069057 SGTC_616 4092-0450 108 µM 0.981607178926046 0.193160073415995 no 664 0.163146704704613 854 787165 SGTC_487 nimodipine 119 µM 0.981431192000027 0.19320301206846 no 665 0.163190075279767 715 4497 L-type voltage-gated calcium channels inhibitor SGTC_1218 1348-1416 30.7 µM 0.981420578690613 0.193205601772108 no 666 0.163192691084797 811 6787668 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.979608283740046 0.193648121987038 no 667 0.163639757174876 869 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1619 st003326 88.7 µM 0.978294593714769 0.193969280550368 no 668 0.163964321509342 789 2849032 SGTC_658 3253-0951 102 µM 0.978174961849177 0.1939985431374 no 669 0.163993898865304 908 1184878 SGTC_13 0199-0087 65 µM 0.973626665911179 0.195113074695749 no 670 0.165120970584365 861 4589825 SGTC_2439 5492030 7.2 µM 0.972557572862525 0.195375613112351 no 671 0.165386618890827 812 5722370 SGTC_1627 st003713 25.6 µM 0.9714010621081 0.195659860304054 no 672 0.165674299925431 892 16195070 YER133W GLC7 SGTC_396 dithiazanine 1.25 µM 0.970934434772833 0.195774619009991 no 673 0.165790464625268 789 10578 An antihelmenthic. SGTC_277 nystatin 15.5 µM 0.969024220361025 0.196244828083116 no 674 0.16626655242102 859 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2611 pyromycin 23.93 µM 0.968719902026103 0.19631980078308 no 675 0.1663424799439 807 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1853 st056710 91.2 µM 0.968591341930349 0.196351478417222 no 676 0.166374562455638 884 269167 SGTC_1902 st060212 70.5 µM 0.967861458689944 0.196531382791374 no 677 0.166556782476172 848 688944 SGTC_1755 st041960 45.185 µM 0.96729455209962 0.196671184956554 no 678 0.166698403184262 827 2257073 SGTC_3218 9131285 49.47 µM 0.964472092670936 0.197368114485237 no 679 0.167404646677973 909 17156417 SGTC_3304 9125678 46.087 µM 0.963776856221776 0.197540013199648 no 680 0.167578906160384 810 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2269 7935389 174.42 µM 0.963287738106227 0.197661002931801 no 681 0.16770157252997 798 97605 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.962408143839533 0.197878694685226 no 682 0.167922312218276 788 6708760 SGTC_1956 st077085 54 µM 0.96210374624849 0.197954064101565 no 683 0.167998746241469 864 24208685 SGTC_3011 9081274 71.4286 µM 0.959878553620953 0.198505552471985 no 684 0.168558170542414 870 6625322 SGTC_1682 st012968 530 nM 0.959545507779792 0.198588173718665 no 685 0.168642002812435 752 24207270 SGTC_2907 7721985 69.9 µM 0.959216740546137 0.198669753878137 no 686 0.168724784378093 827 3267881 SGTC_2286 7945697 125 µM 0.959182643835507 0.198678215777712 no 687 0.168733371214319 818 1245733 SGTC_3231 9132313 49.47 µM 0.955288296300877 0.199646119024049 no 688 0.16971596222582 853 4905967 SGTC_1342 1486-1464 234 µM 0.95520406443427 0.199667085357447 no 689 0.169737255412495 856 3253938 SGTC_830 4076-0286 57.8 µM 0.95236184286668 0.200375325089834 no 690 0.170456751970566 965 6866659 SGTC_2733 amorolfine 100 µM 0.95133361257261 0.200631916213252 no 691 0.170717524594944 805 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2276 7947513 42.08 µM 0.949417164850567 0.201110684934114 no 692 0.171204241849753 775 2105100 SGTC_2480 5767542 37.17 µM 0.947587862262211 0.201568321537633 no 693 0.17166965384176 881 2867358 SGTC_2474 5321570 43.32 µM 0.946311300322064 0.201888048312778 no 694 0.171994915663694 862 2841384 SGTC_1733 st037357 54.9 µM 0.945542690082096 0.202080700227432 no 695 0.172190943471358 837 1272339 YGL099W LSG1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.94478224854412 0.202271412883115 no 696 0.17238502816969 836 803109 SGTC_2071 5230951 39.92 µM 0.942136849792394 0.202935695941171 no 697 0.17306129016232 915 1799272 SGTC_2866 9034245 58.44 µM 0.941397719183066 0.203121530810577 no 698 0.173250540996176 862 6462273 SGTC_3272 9137413 49.47 µM 0.941353462893477 0.203132661108428 no 699 0.173261876786027 831 17614870 SGTC_3351 9150312 21.596 µM 0.940757704250315 0.203282527705106 no 700 0.173414520155688 831 4904905 SGTC_2718 lomofungin 53.02 µM 0.939728383131686 0.20354161493388 no 701 0.173678451161366 840 5351222 A RNA synthesis inhibitor. SGTC_3238 9133470 49.47 µM 0.939701397579989 0.203548410031784 no 702 0.173685374035562 871 3534688 SGTC_3070 9117005 49.47 µM 0.93955429785876 0.203585452861698 no 703 0.173723114088894 830 8779016 SGTC_3005 9076496 71.4286 µM 0.939361345420349 0.203634048473297 no 704 0.17377262607049 855 21368410 SGTC_923 1900-2434 73.3 µM 0.938431437693164 0.203868345315453 no 705 0.174011368103361 842 5910570 SGTC_930 2810-3379 265 µM 0.937685801317171 0.204056329696588 no 706 0.174202951370014 940 1015764 SGTC_1488 4013-0813 75.9 µM 0.935632263297371 0.204574586201725 no 707 0.174731278587425 841 2910057 SGTC_1103 duloxetine 36.1 µM 0.935583576154469 0.204586882994306 no 708 0.174743816980289 952 60835 A selective serotonin reuptake inhibitor. SGTC_1140 3229-1848 2.98 µM 0.934376013548397 0.204892014834994 no 709 0.175054983151674 885 2849525 SGTC_2821 7996764 71.43 µM 0.933229435603464 0.205181987114814 no 710 0.175350759852543 899 2987135 SGTC_1461 k072-0203 53.8 µM 0.933201274554223 0.205189112177684 no 711 0.175358028395173 833 5418714 SGTC_2366 9070441 60.58 µM 0.932315058336743 0.205413409971674 no 712 0.175586863922133 887 6837235 SGTC_2922 7999257 32.47 µM 0.92996995310598 0.20600764880688 no 713 0.17619332091029 815 2988377 SGTC_1778 st046819 58.9 µM 0.929173050284286 0.206209812163319 no 714 0.176399705757463 935 671715 SGTC_1014 4130-3005 69.3 µM 0.928482750062919 0.206385026919548 no 715 0.17657860583723 883 743608 SGTC_2074 5212007 75.395 µM 0.928317302479425 0.20642703458735 no 716 0.17662150072235 827 758611 SGTC_1631 benzylvanillin 81.9 µM 0.928245083931043 0.206445372694729 no 717 0.176640226581215 866 75506 SGTC_3037 9091026 49.47 µM 0.926886512946366 0.206790527896483 no 718 0.176992730232547 964 25236398 YIL048W NEO1 SGTC_1650 st011916 45.8 µM 0.92362709093398 0.207620000353887 no 719 0.177840251971965 899 242528 SGTC_1822 st052468 42 µM 0.923517625266812 0.207647891750004 no 720 0.177868759821586 876 2873678 SGTC_1133 3473-0247 50 µM 0.923157157641335 0.207739753046174 no 721 0.177962655808268 836 711311 SGTC_221 trifluoperazine 10.304 µM 0.920683165897579 0.208370870699908 no 722 0.178607933821328 997 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2715 st079500 56.4 µM 0.918325834945265 0.208973278975211 no 723 0.179224152854382 841 28246688 SGTC_206 4546-0025 72.014 µM 0.918048364176236 0.209044253145894 no 724 0.179296773066158 932 6620745 YIL048W NEO1 SGTC_48 0382-0018 55 µM 0.91708297621238 0.209291300056472 no 725 0.179549580517409 863 762596 SGTC_2246 7293507 91.5585 µM 0.916515068818634 0.209436710231098 no 726 0.179698403804149 934 887656 SGTC_1448 4255-0083 152 µM 0.915243433465064 0.209762522321443 no 727 0.180031923888232 944 5399660 SGTC_2252 omeprazole 400 µM 0.914725037533895 0.209895428605774 no 728 0.180167998409416 817 4594 A proton pump inhibitor. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.91270858597975 0.210412876687398 no 729 0.180697913518447 923 94937 An inhibitor of serotonin biosynthesis. SGTC_2798 7813637 45.45 µM 0.912171569395725 0.210550808398653 no 730 0.180839203868575 869 956368 SGTC_3252 9135871 49.47 µM 0.910827548596925 0.210896250138434 no 731 0.181193122392167 897 17682838 SGTC_496 calpeptin 138 µM 0.91026300369299 0.211041449161318 no 732 0.181341912262057 813 73364 A calpain inhibitor. SGTC_1680 diphenhydramine 100 µM 0.90904316434081 0.211355387706327 no 733 0.181663670850807 868 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3208 9114115 49.47 µM 0.908311691090603 0.211543771197775 no 734 0.181856783709964 796 650895 SGTC_3171 9103192 49.47 µM 0.907987848878595 0.211627204849816 no 735 0.181942320780959 923 13018434 SGTC_2222 6885208 172.143 µM 0.907780531052189 0.211680627650298 no 736 0.181997093247062 890 609514 SGTC_2706 st078239 82.5 µM 0.905000275533213 0.212397821579595 no 737 0.182732620610707 909 15434492 SGTC_1277 0873-0036 22 µM 0.902343036152102 0.213084607424443 no 738 0.183437335436297 938 5965735 SGTC_1867 st057372 64 µM 0.899424944213539 0.213840303207034 no 739 0.184213178803979 911 688837 SGTC_2181 6316240 54.2555 µM 0.898329069348244 0.214124503583877 no 740 0.18450506961793 858 12779990 SGTC_1080 nisoldipine 24.4 µM 0.89823605963047 0.214148634515437 no 741 0.184529856378528 922 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1228 0124-0032 52.5 µM 0.896151891480288 0.214689776963094 no 742 0.185085822857323 950 X1228 SGTC_655 k060-0012 42 µM 0.895582129389151 0.214837850659976 no 743 0.185237991820551 888 5994525 SGTC_258 haloperidol 50.781 µM 0.894753228999764 0.215053376909761 no 744 0.185459508716118 873 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_361 000s-0510 1.45 µM 0.893699638304295 0.215327507050876 no 745 0.185741309482602 892 660 SGTC_755 1995-0008 37.3 µM 0.893289347966259 0.215434313912902 no 746 0.185851120439246 939 689533 SGTC_949 1165-0505 146 µM 0.892113729810475 0.215740521200415 no 747 0.186165988222372 946 6244267 SGTC_3198 9112019 49.47 µM 0.891689096863278 0.215851185177676 no 748 0.18627979960523 914 45595555 SGTC_1367 1812-0510 76.9 µM 0.888374936874593 0.216716021016618 no 749 0.187169551229195 909 1142582 YDR527W RBA50 SGTC_2266 7929956 200 µM 0.887764132162941 0.216875629988849 no 750 0.187333820175588 917 2967153 SGTC_804 1595-0054 20.9 µM 0.887084713829425 0.217053248150557 no 751 0.187516646645235 874 761523 Stimulates phospholipase C. SGTC_1385 3091-4834 14.1 µM 0.88569266502696 0.217417429446953 no 752 0.187891580976736 879 4072814 SGTC_1203 3992-3522 103 µM 0.884700209098358 0.217677286400394 no 753 0.188159171442508 971 5322312 SGTC_605 1315-0399 119 µM 0.883721933236103 0.217933605845493 no 754 0.188423168655677 972 24020461 SGTC_1267 0828-0272 9.49 µM 0.883385305581535 0.218021846365525 no 755 0.188514063692884 950 745334 SGTC_3327 9140648 26.9345 µM 0.882054179478267 0.21837097738484 no 756 0.188873754551234 935 8029710 SGTC_2059 5238311 157 µM 0.874212896715193 0.220434133428685 no 757 0.191001161969357 893 703021 SGTC_2753 fluvastatin 17.09 µM 0.873782165556926 0.220547787863192 no 758 0.191118447307757 929 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1992 st073643 23.3 µM 0.873768820412456 0.220551309702198 no 759 0.191122081810371 928 3161292 SGTC_667 1498-1044 59 µM 0.87226719323668 0.220947801103986 no 760 0.191531315273349 972 6739982 SGTC_2525 harmine 47.85 µM 0.872014521069218 0.221014557039972 no 761 0.19160022790515 903 5280953 A monoamine oxidase inhibitor SGTC_3110 9122132 49.47 µM 0.866399598801131 0.222500993927121 no 762 0.193135531945928 976 918317 SGTC_2365 9042475 200 µM 0.864782266354391 0.222930205072541 no 763 0.19357915314427 926 6464479 SGTC_881 0833-0569 170 µM 0.864027086654954 0.223130777691116 no 764 0.193786505484257 909 5418700 SGTC_2924 9010168 62.78 µM 0.863248718899467 0.223337616445292 no 765 0.19400036628782 951 2993929 SGTC_1437 4092-1038 11.6 µM 0.862274142721423 0.223596748210175 no 766 0.194268339092621 999 3977136 SGTC_2832 7992762 51.95 µM 0.861053304301656 0.223921600198781 no 767 0.194604342867818 815 2985177 SGTC_1764 st044502 93.5 µM 0.858545790333111 0.224589663137605 no 768 0.195295578562817 952 8407 SGTC_1280 0880-0253 10.1 µM 0.858488767350173 0.224604868589988 no 769 0.195311315173742 950 6836607 SGTC_2597 laccaic acid a 100 µM 0.858340758564307 0.224644338568901 no 770 0.195352164696967 933 5491415 A textile dye. SGTC_1259 0671-0132 43 µM 0.856463182383366 0.225145379241367 no 771 0.195870814715159 908 X1259 SGTC_3299 9121982 43.1275 µM 0.85159824521758 0.226446553297515 no 772 0.197218556944724 980 17594604 YPL160W CDC60 SGTC_2099 5377090 177.372 µM 0.851430139112732 0.226491590657114 no 773 0.197265227740608 934 2243829 SGTC_3008 9078912 71.4286 µM 0.850373007460076 0.226774923005454 no 774 0.197558869124899 949 16648731 SGTC_1604 st002052 72.4 µM 0.85005252897843 0.22686085711081 no 775 0.1976479411866 954 6254834 YHR062C RPP1 SGTC_3105 9121040 49.47 µM 0.848639199683078 0.227240050716351 no 776 0.198041043786982 782 41448907 SGTC_3275 9138069 49.47 µM 0.848088906377724 0.227387789938512 no 777 0.198194229668913 962 17617007 SGTC_35 0133-0054 64.071 µM 0.846733478944561 0.227751917099588 no 778 0.198571846766507 930 99677 SGTC_888 0916-0002 6.97 µM 0.845709498118967 0.228027220669003 no 779 0.198857411611459 1002 2802138 YIL048W NEO1 SGTC_3130 9127414 49.47 µM 0.845483678324327 0.228087958895973 no 780 0.198920420889342 978 1494646 SGTC_1284 0929-0043 16 µM 0.845080443824453 0.228196438569686 no 781 0.199032963156791 972 1239883 SGTC_668 1682-0499 62.6 µM 0.843480517730479 0.228627142496658 no 782 0.199479878588965 1003 682214 SGTC_1165 k072-0275 30.3 µM 0.842805135543883 0.22880909393939 no 783 0.199668717679811 1000 6153523 YGL055W OLE1 SGTC_3086 9117350 49.47 µM 0.840282275245717 0.229489483942574 no 784 0.200375068524462 953 2679265 SGTC_1762 st045503 25.4615 µM 0.839238004679787 0.229771444615234 no 785 0.200667882293006 1009 4645554 SGTC_1097 itavastatin 7.23 µM 0.838884455412055 0.229866949435599 no 786 0.200767075788075 1027 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1856 st057054 55.7 µM 0.836458174705723 0.230522963700421 no 787 0.201448598493809 1024 1266018 SGTC_1661 st013063 9.66 µM 0.835721364847915 0.2307223882149 no 788 0.201655836572817 1059 721395 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.832202956687745 0.231676006139136 no 789 0.202647197631816 994 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1422 4031-0024 15.5 µM 0.830653792083746 0.232096582115673 no 790 0.20308461856465 986 782427 SGTC_2105 5350118 200 µM 0.829953991063365 0.232286707324555 no 791 0.203282398548921 1001 2133313 SGTC_2385 9074692 200 µM 0.828692061451405 0.232629773169195 no 792 0.203639339502403 967 17046906 SGTC_1375 2910-0797 186 µM 0.826918260403333 0.233112471274929 no 793 0.204141696361135 985 742508 SGTC_2565 isoliquiritigenin 100 µM 0.826340542280521 0.233269803598442 no 794 0.204305470692462 852 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3000 9075062 71.4286 µM 0.825630795945753 0.233463172346816 no 795 0.204506780072438 948 17057871 SGTC_1531 st059297 52.4 µM 0.824770098181719 0.233697786707031 no 796 0.204751062972909 1013 7566702 SGTC_1530 rhein 70.4 µM 0.823073372525167 0.234160673324045 no 797 0.205233134984077 1074 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.822277072976134 0.234378088069323 no 798 0.205459611131532 1065 1377 SGTC_1149 3909-7961 23.3 µM 0.820224097606038 0.234939129640977 no 799 0.206044183489342 999 735261 SGTC_1273 0849-0096 14.1 µM 0.819853173912418 0.235040575569536 no 800 0.206149906878461 987 5286025 SGTC_2446 5162541 200 µM 0.818208184180464 0.235490764215607 no 801 0.206619161359262 954 1549321 SGTC_618 k072-0232 33.2 µM 0.818193282721035 0.235494844510417 no 802 0.206623415081427 991 5872756 YGL099W LSG1 SGTC_764 1951-2361 146 µM 0.817638386927368 0.235646812997006 no 803 0.206781850751372 954 5438930 SGTC_2472 5377652 49.4 µM 0.817463865711204 0.235694620042144 no 804 0.206831695485733 1005 1610903 SGTC_2701 st077767 14.721 µM 0.816347446056975 0.236000570264359 no 805 0.207150722610799 1031 5721188 SGTC_1328 1441-0025 69.2 µM 0.816068144149967 0.236077146015346 no 806 0.207230581179914 983 4562601 SGTC_1001 4048-4355 44.4 µM 0.815741633164637 0.236166682355616 no 807 0.207323960944221 982 21824233 SGTC_2533 agelasine 13.65 µM 0.81443285836409 0.236525764260729 no 808 0.207698510659618 1045 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1743 st037606 46.3785 µM 0.813659249911178 0.236738156490742 no 809 0.207920092463721 998 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1297 1068-0111 14.1 µM 0.812425433080497 0.237077114708289 no 810 0.208273778734263 988 767057 SGTC_1738 st035555 74 µM 0.81181867884257 0.237243901998044 no 811 0.208447841189664 1023 5331140 SGTC_2734 clemastine 41.6 µM 0.808202404743045 0.238239294927104 no 812 0.209487036820514 958 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1518 st038567 90.8 µM 0.808051941482292 0.238280760019172 no 813 0.209530340847916 1035 77966 SGTC_1567 st069303 68.4 µM 0.805602881861927 0.238956234348466 no 814 0.21023593170354 1037 5581319 SGTC_1244 0416-0015 52.5 µM 0.805404517920973 0.239010990840541 no 815 0.210293142738008 1013 96201 SGTC_56 0957-0365 83.25 µM 0.802487701057279 0.239816942094273 no 816 0.211135449988642 1020 6752360 SGTC_2867 9039098 71.43 µM 0.801783002770475 0.240011880759944 no 817 0.21133924622377 1006 6463460 SGTC_2272 7805186 180 µM 0.800393324912241 0.240396556423601 no 818 0.21174147360652 1034 2956062 YPR165W RHO1 SGTC_420 mitomycin C 81.9 mM 0.79942550136821 0.240664657174783 no 819 0.212021864225727 1017 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3221 9128209 49.47 µM 0.798872767055884 0.24081784534803 no 820 0.212182095659474 1000 16460723 SGTC_1985 st071382 65.5 µM 0.797800071984646 0.241115289958674 no 821 0.212493259766679 1109 6123237 SGTC_2229 7354935 190 µM 0.797284099544047 0.241258433621643 no 822 0.212643026373504 1009 318112 SGTC_72 0744-0168 198.391 µM 0.796762605910701 0.241403155915567 no 823 0.212794458182242 997 677577 SGTC_629 3448-6466 76.7 µM 0.794977211592307 0.24189898650455 no 824 0.213313379121517 1054 573744 SGTC_2290 7904846 200 µM 0.791452791022909 0.242879390287802 no 825 0.214339907190032 1056 2962154 SGTC_1881 5652484 16 µM 0.790492906367915 0.243146777724241 no 826 0.214619981666429 1012 2255129 SGTC_1261 0712-0010 12.7 µM 0.790326076237202 0.243193266497561 no 827 0.21466868093436 1076 2840123 SGTC_2332 7982454 138.89 µM 0.790146089414312 0.243243426894295 no 828 0.214721227964197 1038 2981748 SGTC_518 1021-0119 62.6 µM 0.789966538071512 0.2432934714992 no 829 0.214773655302373 967 1097762 SGTC_3325 9138760 55.175 µM 0.78994250076077 0.243300171608108 no 830 0.214780674540147 1029 43844959 SGTC_1976 st070609 63.5 µM 0.789918338887943 0.243306906537688 no 831 0.214787730286147 1039 682556 SGTC_3089 9117425 49.47 µM 0.789890132902024 0.243314768859045 no 832 0.214795967163729 1023 9401657 SGTC_2150 5556613 200 µM 0.78946103280164 0.243434395965348 no 833 0.214921298124782 1065 743190 SGTC_2646 retinol 96.75 µM 0.788948127585992 0.243577428447563 no 834 0.215071162480722 1046 445354 A vitamin A analog and teratogen. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.787048886708407 0.244107459558473 no 835 0.215626624443782 1056 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1127 asiatic acid 681.4 nM 0.786068192234178 0.244381390426152 no 836 0.215913768851321 1002 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1824 st053723 68.6 µM 0.785993211396804 0.244402341139776 no 837 0.215935732130131 1077 675225 SGTC_2997 9067075 71.4286 µM 0.784921065919682 0.244702019688003 no 838 0.216249924998811 1057 27209819 SGTC_3161 9100388 49.47 µM 0.783755100557382 0.245028146553784 no 839 0.216591912089773 1098 25236368 SGTC_1446 4239-0190 62 µM 0.779900065620876 0.246108083344212 no 840 0.217724849922423 1064 1340085 SGTC_3004 9076122 71.4286 µM 0.778141741821077 0.246601500829678 no 841 0.218242728536832 1065 44782551 SGTC_273 hydroxyurea 18.1 mM 0.777677893077406 0.246731753456642 no 842 0.218379464000468 1145 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1374 2889-5571 141 µM 0.77697412106156 0.246929448881845 no 843 0.218587019352437 1065 2853281 SGTC_1255 0566-0045 221 µM 0.776741826010323 0.246994721101256 no 844 0.218655552370634 1062 2788469 SGTC_2038 4100038 30.985 µM 0.775876478108218 0.247237955070748 no 845 0.2189109611019 1029 3596803 SGTC_2789 5281112 71.43 µM 0.773658662673256 0.247861928032272 no 846 0.219566335677212 1064 765948 SGTC_2717 st081029 62.2815 µM 0.773296573501493 0.247963880047245 no 847 0.219673441587863 1060 5292846 SGTC_2078 5212016 200 µM 0.771680539438773 0.24841917304683 no 848 0.22015182974886 1040 1899708 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.770241157562869 0.248825071829509 no 849 0.220578426915543 1107 688761 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.768535019685271 0.24930665143188 no 850 0.221084696825449 1128 4174840 SGTC_2889 9059656 51.95 µM 0.768154202782507 0.249414209561226 no 851 0.221197789027454 1123 3949838 SGTC_919 tnp00227 403.569 nM 0.768093694312855 0.249431301876154 no 852 0.221215761434073 1083 1269246 A methoxyflavone. YNL221C POP1 SGTC_1361 1608-0041 5.61 µM 0.766253600153349 0.249951385287573 no 853 0.22176271052538 1084 X1361 SGTC_950 1165-0508 94.1 µM 0.764877680690933 0.25034065029142 no 854 0.222172192770874 1057 6148369 SGTC_2630 antimycin a 100 µM 0.763847121273434 0.250632418939104 no 855 0.222479176137562 1146 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1880 MG-132 525 µM 0.763290345049215 0.250790126535203 no 856 0.222645129411036 1041 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_66 0109-0187 42.4 µM 0.761993708837269 0.251157604005013 no 857 0.223031879479932 991 759417 SGTC_725 1497-0963 19 µM 0.761173501455745 0.251390204560376 no 858 0.223276721668274 1117 3549977 SGTC_920 mycophenolic acid 780.421 nM 0.759559305415471 0.251848302705226 no 859 0.223759025943407 1053 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1136 pergolide 1.05886 µM 0.75945495839208 0.251877930855858 no 860 0.223790224069528 1050 47811 A dopamine receptor agonist. SGTC_2854 9024559 71.43 µM 0.758016814871527 0.252286462700925 no 861 0.224220458262982 1090 3163529 SGTC_1904 st060225 78 µM 0.755001710964264 0.253144092642425 no 862 0.225123977809804 1111 66595 SGTC_1596 piperlongumine 63 µM 0.754888439286638 0.253176342015916 no 863 0.225157961462071 1135 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3147 9097027 49.47 µM 0.75462928439371 0.253250133660542 no 864 0.225235723776306 1110 25236841 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.754492836973594 0.253288990180071 no 865 0.225276672457689 1046 279621 SGTC_711 k292-0785 179 µM 0.747127444077473 0.25539109641938 no 866 0.227493317791141 1160 4146315 SGTC_1098 clofazimine 15.1 µM 0.746522041466062 0.255564284829701 no 867 0.227676060933268 1116 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2978 9011784 42.97 µM 0.746110351916862 0.255682092494938 no 868 0.227800378221664 1188 2994934 SGTC_2142 5622915 118.518 µM 0.745578108568073 0.255834439438912 no 869 0.227961155567217 1104 5322196 SGTC_3078 9116413 49.47 µM 0.745457214785428 0.255869050133886 no 870 0.227997683436282 1098 17177322 SGTC_761 k216-0224 480 µM 0.74537469808979 0.25589267525133 no 871 0.228022617618374 1159 1340404 SGTC_1510 1123-0200 71.5 µM 0.745163389576948 0.255953179572702 no 872 0.228086475991024 1151 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2186 6124449 200 µM 0.74514885873752 0.25595734048664 no 873 0.228090867644886 1089 3834182 YLR033W RSC58 SGTC_1176 0848-0131 83.3 µM 0.743174450024325 0.256523041549237 no 874 0.228688034973871 1188 6769040 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.742578936570171 0.256693793852008 no 875 0.228868322429181 1155 3256 An antibiotic and ribosome inhibitor. SGTC_2398 5228213 48.84 µM 0.739459636215945 0.257589160535582 no 876 0.229813970519986 1172 80771 YMR134W ERG29 SGTC_3003 9075612 71.4286 µM 0.739267455746296 0.257644377176758 no 877 0.229872303470125 1109 6501993 SGTC_1126 isoteolin 1.0172 µM 0.738781669511772 0.257783979028076 no 878 0.230019792159513 1137 133323 SGTC_228 caffeine 993.056 µM 0.738191779396349 0.257953550290949 no 879 0.230198958815839 1094 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3131 9127911 49.47 µM 0.737019978031308 0.258290570757572 no 880 0.230555100163688 1140 45595681 SGTC_1368 1852-0141 284 µM 0.736105797135207 0.258553655665098 no 881 0.230833157538334 1107 2838987 SGTC_1068 loratadine 26.9 µM 0.735408994159449 0.258754276253653 no 882 0.231045222930564 1105 3957 A H1 histamine antagonist. SGTC_2114 5491910 81.25 µM 0.733979848731819 0.259166001746474 no 883 0.231480509860522 1141 2849228 SGTC_102 gallobenzophenone 83.616 µM 0.733129500643665 0.259411140908071 no 884 0.231739724386277 1138 70837 SGTC_921 1561-0023 372 µM 0.733044662918859 0.259435604578172 no 885 0.231765594630688 1180 24050882 SGTC_3234 9132280 49.47 µM 0.732912728674358 0.259473651292525 no 886 0.23180582958922 1154 17612295 SGTC_2557 derrustone 83.84 µM 0.73285238049869 0.259491055238951 no 887 0.231824234799008 1155 629853 An antioxidant. SGTC_3080 9117754 49.47 µM 0.732769201828408 0.259515044311288 no 888 0.231849604271657 1168 9550191 SGTC_3209 9113616 49.47 µM 0.731977556698325 0.259743415345015 no 889 0.232091133210306 1159 16649353 SGTC_1605 st000082 49.1 µM 0.731525973368078 0.259873732972356 no 890 0.232228972861124 1143 1114022 SGTC_3324 9138759 60.749 µM 0.731143312989951 0.259984187252675 no 891 0.232345810367889 1139 45595710 SGTC_825 1988-2224 89.6 µM 0.730856613669729 0.260066958395554 no 892 0.232433369555441 1119 1180859 SGTC_1154 4088-0362 150 µM 0.729693044161976 0.260403024581166 no 893 0.232788916928807 1182 6618304 SGTC_1916 st067606 49.2 µM 0.727209670359257 0.261121028643206 no 894 0.233548761556557 1171 19590279 SGTC_2433 5607874 27.82 µM 0.726576131778625 0.261304362904261 no 895 0.233742827053028 1164 2252428 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.725300953558446 0.261673576111538 no 896 0.234133710442648 1120 4620898 SGTC_2167 5876490 200 µM 0.724938042167078 0.261778701850241 no 897 0.234245020656714 1155 686534 SGTC_329 k048-0121 21.3 µM 0.72358543839759 0.262170705806655 no 898 0.234660141899277 1149 6832902 SGTC_1700 st030840 7.9285 µM 0.723481237209696 0.262200917277729 no 899 0.234692138662567 1152 5499307 SGTC_3255 9139072 49.47 µM 0.722550127358869 0.262470956874615 no 900 0.234978158987288 1180 17646060 SGTC_369 0957-0393 4.5 µM 0.722354314364663 0.26252776448773 no 901 0.235038333744737 1142 6997992 SGTC_660 4031-1742 102 µM 0.721714077016229 0.262713548661003 no 902 0.235235142748279 1100 6738706 SGTC_3316 9136639 10.545 µM 0.720231406585258 0.263144048281057 no 903 0.235691264905251 1140 4903665 SGTC_39 0986-0283 58.349 µM 0.719853332794465 0.263253881245382 no 904 0.235807651847284 1195 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1439 4092-1168 46 µM 0.718536179550254 0.263636705863135 no 905 0.23621337414783 1143 2886240 SGTC_291 SEC14.278 35.5 µM 0.718338635451058 0.263694145642181 no 906 0.236274256731917 1181 1068044 SGTC_1229 0139-0193 12.2 µM 0.717807300724387 0.263848673190648 no 907 0.236438055599891 1191 3090752 SGTC_1865 st057639 52.2 µM 0.717474225561221 0.263945564644744 no 908 0.236540767246206 1176 688818 SGTC_337 1315-0038 354 µM 0.717121649243349 0.264048148733871 no 909 0.236649519283355 1140 1626437 SGTC_1100 amiodarone 5.07 µM 0.716217153539694 0.264311409790231 no 910 0.23692863640641 1188 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_922 1866-0035 480 µM 0.715148790793648 0.264622537777689 no 911 0.237258554029724 1175 3156169 SGTC_3187 9109394 49.47 µM 0.714993182075057 0.264667869597643 no 912 0.23730662809512 1137 17098090 SGTC_3023 9089636 49.47 µM 0.714991429327692 0.264668380229238 no 913 0.237307169622824 1257 17249241 SGTC_3118 9124250 49.47 µM 0.714845338379695 0.264710942975201 no 914 0.237352308174144 1064 1504786 SGTC_1699 st031318 29.054 µM 0.714452527764541 0.264825403317185 no 915 0.237473700482082 1194 5340658 SGTC_2473 5854593 8.94 µM 0.713764908899309 0.265025827828989 no 916 0.237686280938644 1118 2872951 SGTC_870 0573-2213 57.6 µM 0.713567579116058 0.265083358985678 no 917 0.237747305600052 1175 3916321 SGTC_1021 4476-0760 85.3 µM 0.713550179962075 0.265088431983219 no 918 0.237752686738251 1157 746768 SGTC_1861 st057647 17.4 µM 0.712043383342521 0.265527949262128 no 919 0.238218955880859 1183 688668 SGTC_703 3875-0075 71.8 µM 0.711388537626516 0.265719076282454 no 920 0.238421750008234 1212 2850814 SGTC_2340 7987427 183.45 µM 0.707518991702776 0.266849886077209 no 921 0.239622007370815 1132 2239331 SGTC_2343 7990716 14.84 µM 0.706118476566974 0.267259761545261 no 922 0.240057231207791 1168 6456862 SGTC_3167 9103034 49.47 µM 0.70248931715107 0.268323349345033 no 923 0.241187030790164 1194 5127859 SGTC_259 usnic acid 108.925 µM 0.701302635552566 0.268671588185176 no 924 0.241557084654498 1262 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2880 9042983 58.44 µM 0.699908617738106 0.269080960949757 no 925 0.24199218760641 1202 6464714 SGTC_2197 6588183 93.1375 µM 0.699310059325953 0.269256831978588 no 926 0.242179140927099 1182 884136 SGTC_2911 7942208 15.64 µM 0.695106758871769 0.270493485658212 no 927 0.243494199681445 1183 1243384 SGTC_707 0865-0008 204 µM 0.692030173707847 0.271400443535392 no 928 0.244459190127939 1208 723043 SGTC_855 0428-0020 25 µM 0.689609729167949 0.272115038650658 no 929 0.245219823699656 1197 6812414 SGTC_2626 ethyl orsellinate 100 µM 0.688074730776367 0.272568705029218 no 930 0.24570286116493 1205 75653 A natural product. SGTC_295 k015-0027 31 µM 0.687228999944895 0.272818819784408 no 931 0.245969216176786 1193 3887424 SGTC_1142 3253-1408 9.78 µM 0.685816516587064 0.273236798495276 no 932 0.246414409826285 1193 256655 SGTC_532 1548-0774 215 µM 0.685340260952999 0.273377802410015 no 933 0.246564615776622 1304 5932993 SGTC_415 dibenzyl ketone 100 µM 0.68528830822684 0.273393186114039 no 934 0.246581004079238 1196 7593 SGTC_2914 7968218 45.32 µM 0.684533894631459 0.273616623559816 no 935 0.246819046905171 1145 2977111 SGTC_2830 7992007 71.43 µM 0.683504762727399 0.273921570966039 no 936 0.247143970849202 1156 1952075 SGTC_2852 9023854 51.95 µM 0.682240974701159 0.27429628023318 no 937 0.247543294648064 1265 19798528 SGTC_2400 5203494 178.7 µM 0.681173626496056 0.27461294270808 no 938 0.247880816939864 1197 6777674 SGTC_2087 5276107 200 µM 0.678254162368715 0.275480013800169 no 939 0.248805278200569 1210 144405 SGTC_640 3381-0960 37.1 µM 0.677850417725591 0.275600030523318 no 940 0.248933270053863 1258 1745025 SGTC_1370 2001-0092 44.6 µM 0.677272301319718 0.275771925571324 no 941 0.249116600823185 1306 790957 SGTC_2477 5967686 25.23 µM 0.675179394391398 0.276394663264033 no 942 0.24978089821103 1226 776118 SGTC_1713 st033146 12.748 µM 0.673133031498971 0.277004218057001 no 943 0.25043133060905 1237 674619 SGTC_98 0074-0023 107.663 µM 0.672961563237712 0.277055323564543 no 944 0.250485872187482 1205 3563821 SGTC_1709 st033179 39.1045 µM 0.672547240421363 0.277178830055289 no 945 0.250617688270414 1212 573381 SGTC_470 aa-861 153 µM 0.667536926997004 0.278674495194256 no 946 0.252214615284567 1211 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_638 3970-0837 4.09 µM 0.667484690166852 0.278690109465508 no 947 0.252231292841702 1235 4118451 YLR208W SEC13 SGTC_2444 5485484 36.41 µM 0.663407265466273 0.279910217439687 no 948 0.253534876972334 1301 6790631 SGTC_1512 0259-0544 12.2 µM 0.662428082078499 0.280203608598168 no 949 0.253848455705124 1242 18476 SGTC_1198 1612-1005 86.7 µM 0.661126051642192 0.280593964524336 no 950 0.254265739762674 1309 6998509 SGTC_384 k007-0144 5.16 µM 0.660502698505625 0.280780942339711 no 951 0.254465643678271 1253 6824886 SGTC_132 0417-1715 25.805 µM 0.659801042130194 0.280991479645268 no 952 0.254690757241373 1279 6769098 SGTC_1031 k035-0009 16 µM 0.659708440314289 0.281019271218279 no 953 0.254720474621348 1263 5180959 SGTC_1702 st027038 51 µM 0.659456368752468 0.281094929434546 no 954 0.25480137754915 1264 5521182 SGTC_1837 st055472 66.5 µM 0.657910610516291 0.281559097304607 no 955 0.255297786099237 1309 676091 SGTC_2424 5537928 59.2 µM 0.655787324184934 0.282197290203511 no 956 0.255980486697508 1296 5382802 SGTC_353 1988-1175 58.3 µM 0.655163431334635 0.282384944977627 no 957 0.256181267968493 1181 2788357 SGTC_3303 9125618 40.5795 µM 0.652387016546714 0.283220763409892 no 958 0.25707576894168 1291 22695467 SGTC_1672 st016598 6.51 µM 0.651477625819498 0.283494786310554 no 959 0.257369107788917 1236 4665860 YNL267W PIK1 SGTC_1272 0839-0021 27 µM 0.650127785355722 0.283901762211397 no 960 0.257804841382062 1275 5027250 SGTC_2054 5233173 129 µM 0.649690313320532 0.284033719678 no 961 0.257946141109421 1280 6889 SGTC_2238 6671620 73.2395 µM 0.648890023589204 0.284275192057 no 962 0.258204731787022 1235 729941 SGTC_1302 1159-0335 255 µM 0.646291083556014 0.285060049419586 no 963 0.259045430630261 1280 649284 SGTC_164 4100-3994 89.624 µM 0.645226700353871 0.285381781845814 no 964 0.25939014285007 1301 4615967 SGTC_1035 k081-0041 55.2 µM 0.644247592565306 0.285677890591491 no 965 0.259707446812539 1296 731709 SGTC_3183 9108214 49.47 µM 0.641799937928185 0.286418766519132 no 966 0.260501544982315 1209 4974831 SGTC_1266 0828-0227 32.9 µM 0.641125247102301 0.286623147606731 no 967 0.260720656075726 1266 3913820 SGTC_1420 4'-methoxyflavone 42 µM 0.640740365147847 0.286739769157638 no 968 0.260845691952166 1283 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1070 indatraline 8.81 µM 0.640322286030862 0.286866475132618 no 969 0.260981547471429 1262 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2037 5169046 200 µM 0.639162132314442 0.287218218311087 no 970 0.261358731865209 1300 5718022 SGTC_219 mitoxanthrone 164.414 µM 0.637210345791484 0.28781043419424 no 971 0.261993919810928 1290 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3051 9093778 49.47 µM 0.636882701851275 0.287909905238631 no 972 0.262100625534435 1301 17217378 SGTC_613 3914-0030 117 µM 0.635609068727301 0.288296727937968 no 973 0.26251562857057 1102 1145395 SGTC_3242 9133940 49.47 µM 0.634960936169364 0.288493670185268 no 974 0.262726946374341 1331 17248444 SGTC_2208 7283366 200 µM 0.633748287102291 0.288862317204085 no 975 0.263122553297777 1289 898663 SGTC_2708 st078559 56 µM 0.632385978223916 0.289276725271083 no 976 0.263567347036923 1226 17250902 SGTC_2812 7970281 58.44 µM 0.631512014973484 0.289542727897141 no 977 0.263852897854348 1336 2233435 SGTC_204 PMA1.184 62.41 µM 0.630438315554397 0.289869680089918 no 978 0.264203924443685 1313 2252213 YGL008C PMA1 SGTC_2725 haloperidol 53.21 µM 0.628311686299887 0.290517770581363 no 979 0.264899888769283 1254 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2215 7188065 200 µM 0.628074985902755 0.290589946971043 no 980 0.264977409331952 1319 940217 SGTC_1179 1021-1431 9.29 µM 0.627879795490793 0.290649472148136 no 981 0.2650413438381 1305 2840958 SGTC_3233 9132340 49.47 µM 0.62388052258547 0.29187034227642 no 982 0.266353026313612 1261 17682950 SGTC_2119 5528445 120.635 µM 0.62112118041056 0.292714085177182 no 983 0.26725994718602 1351 791935 SGTC_1462 k081-0014 26.5 µM 0.620983123049979 0.29275632965889 no 984 0.267305363793147 1121 3270634 SGTC_1770 st043884 66.3 µM 0.619647716977575 0.293165099617308 no 985 0.267744872052516 1301 670149 SGTC_2388 9080168 200 µM 0.617179881356097 0.293921203726666 no 986 0.268558042122181 1260 15943073 SGTC_887 0885-0007 9.62 µM 0.616515129162933 0.294125026901831 no 987 0.268777294913495 1362 5719458 SGTC_583 1488-1091 88.9 µM 0.615952948215408 0.294297451127842 no 988 0.268962787150504 1390 4303273 SGTC_2617 dihydrotanshinone i 20.83 µM 0.614992700226433 0.294592072791411 no 989 0.26927977061727 1335 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_308 4092-1169 104 µM 0.614204351765581 0.294834054202627 no 990 0.269540149022564 1298 2268590 YDL196W YDL196W SGTC_585 0kpi-0023 191 µM 0.612374601639437 0.295396043839696 no 991 0.270144970951319 1316 64601 SGTC_1520 flindersine 88 µM 0.611528763637653 0.295656001063541 no 992 0.270424791044197 1454 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_194 1486-1323 56.904 µM 0.61082824834745 0.295871374825297 no 993 0.270656645090745 1293 5178754 SGTC_1060 3448-7350 82 µM 0.607862373828892 0.296784031691109 no 994 0.27163937822019 1336 570178 SGTC_2947 9072639 7.68 µM 0.606673763020973 0.297150151571834 no 995 0.272033718697621 1307 16488146 SGTC_289 k017-0060 526 µM 0.605552327016921 0.297495769231887 no 996 0.272406033675779 1318 5512909 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.60408644584271 0.297947818714946 no 997 0.272893085235526 1295 140250 A respiratory chain inhibitor. SGTC_3191 9110352 49.47 µM 0.602335095928409 0.298488311399432 no 998 0.273475551877963 1358 17122424 SGTC_3201 9113999 49.47 µM 0.601404804057937 0.29877559462725 no 999 0.273785199857252 1391 16649224 SGTC_850 0388-0143 75.9 µM 0.600247542934852 0.299133143468475 no 1000 0.2741706364802 1326 67273 SGTC_3349 9149703 23.001 µM 0.600125017092972 0.299171010572912 no 1001 0.2742114605414 1316 4910494 SGTC_1820 st053765 18.6 µM 0.59897853007475 0.299525442365201 no 1002 0.27459360092842 1313 3690829 SGTC_3067 9117431 49.47 µM 0.598914995974763 0.299545089238003 no 1003 0.274614785425061 1327 17150885 SGTC_3175 9106517 49.47 µM 0.598757937669543 0.299593659435484 no 1004 0.274667157630308 1305 41468073 SGTC_1804 st050076 49.1 µM 0.596914194557393 0.300164102654116 no 1005 0.275282334905801 1363 3895976 SGTC_719 2810-4230 27.3 µM 0.59662666406638 0.300253107140606 no 1006 0.275378332478065 1347 721079 SGTC_317 4495-0002 170 µM 0.596512457927392 0.300288462731874 no 1007 0.275416466959529 1302 15991618 SGTC_77 0828-0286 12.516 µM 0.595390684500214 0.300635837925741 no 1008 0.275791175472322 1307 745345 SGTC_1917 st066507 28.5 µM 0.591417100112898 0.301867778957047 no 1009 0.277120492778156 1363 3156428 SGTC_2950 9072895 21.46 µM 0.590919423615569 0.302022234663415 no 1010 0.277287205443769 1301 17332245 SGTC_2993 9054257 71.4286 µM 0.590716219232535 0.30208531008391 no 1011 0.27735528935289 1348 6470217 YGL055W OLE1 SGTC_741 4582-0002 126 µM 0.589761199580786 0.302381831037215 no 1012 0.277675379444678 1324 2912688 SGTC_730 1436-0052 41.2 µM 0.589458571450927 0.302475820293868 no 1013 0.27777684773239 1348 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1719 st032227 49.2 µM 0.588616450216048 0.302737432468887 no 1014 0.278059298098851 1347 3125804 SGTC_814 3342-0569 96 µM 0.587879659288096 0.302966405974319 no 1015 0.27830653518449 1394 4346283 SGTC_2468 5987765 72.9 µM 0.5863462428666 0.303443196175387 no 1016 0.278821430739456 1423 26772094 SGTC_786 4544-0069 423 µM 0.584407777384047 0.304046408834746 no 1017 0.279472997714497 1419 748821 YLR208W SEC13 SGTC_1553 gossypol 38.6 µM 0.58364667274939 0.304283395796573 no 1018 0.2797290261196 1300 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1845 st056753 3.01 µM 0.58130446916044 0.305013208827728 no 1019 0.2805176345331 1293 5375839 SGTC_3241 9133421 49.47 µM 0.58018725369299 0.30536159839241 no 1020 0.280894174137756 1378 17018221 SGTC_797 k781-0471 270 µM 0.579811412631398 0.305478839353412 no 1021 0.281020900254308 1409 23738129 SGTC_2333 9017922 200 µM 0.573240234487405 0.307531887186522 no 1022 0.283241022791287 1485 3163164 SGTC_1042 0350-0096 82 µM 0.571580947601622 0.308051260163038 no 1023 0.283802952994983 1359 3122515 SGTC_2055 5235184 200 µM 0.571416960959839 0.308102610483734 no 1024 0.28385851729509 1393 2836034 SGTC_1696 st025591 34.7925 µM 0.568593456190534 0.308987343403082 no 1025 0.284816033353312 1396 2787147 SGTC_2797 7859098 81.82 µM 0.568238876290186 0.309098527971949 no 1026 0.284936388473041 1397 972681 SGTC_293 4049-0273 38.5 µM 0.566886263648708 0.309522823248252 no 1027 0.285395728654146 1331 1380311 SGTC_2251 lansoprazole 556 µM 0.565665725336349 0.309905906748523 no 1028 0.285810519519252 1308 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1389 3405-0187 19 µM 0.564999231791373 0.310115182526827 no 1029 0.286037143348528 1339 799890 SGTC_2378 9074213 121.43 µM 0.564626769081761 0.310232160833512 no 1030 0.2861638268073 1360 657714 SGTC_512 prima-1 270 µM 0.563819115976909 0.310485884110362 no 1031 0.286438620422159 1461 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2475 5812728 15.03 µM 0.563547613456437 0.31057119657128 no 1032 0.286531023789375 1364 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1757 st041620 31.8375 µM 0.562491598634251 0.310903118054564 no 1033 0.286890563056048 1369 5289815 SGTC_2149 5554786 194.827 µM 0.562487495852307 0.310904407921502 no 1034 0.28689196033884 1390 745063 YPR165W RHO1 SGTC_2212 7123476 200 µM 0.560881038685656 0.311409637803476 no 1035 0.287439318466646 1392 1085715 SGTC_2496 diffractaic acid 79.83 µM 0.560353454962485 0.311575640158665 no 1036 0.287619186454281 1501 94870 An apoptosis inducer which activates caspases. SGTC_122 0236-0016 402.397 µM 0.558503383506687 0.312158061117359 no 1037 0.288250347361009 1418 6808838 SGTC_688 0527-0193 473 µM 0.557543633244449 0.312460385249332 no 1038 0.288578027985935 1422 4007154 SGTC_632 0781-2353 4.65 µM 0.556388581019023 0.312824397491591 no 1039 0.288972621692655 1435 6811515 YHR007C ERG11 SGTC_840 0245-0196 390 µM 0.556240385544528 0.312871114202495 no 1040 0.289023267210796 1477 3827528 SGTC_2256 7954252 200 µM 0.556159530338663 0.312896604029935 no 1041 0.289050901082146 1342 2972920 SGTC_2920 7982904 15.77 µM 0.5552112650105 0.313195614036422 no 1042 0.289375082294045 1382 6456808 SGTC_893 0958-0369 48.9 µM 0.554106428179111 0.31354414963265 no 1043 0.289753005551603 1490 6819948 SGTC_450 aminopyrene 156 nM 0.553303362404579 0.313797592038894 no 1044 0.290027849510442 1429 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2429 5902844 64.44 µM 0.552039853059822 0.314196525371103 no 1045 0.290460524476484 1453 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1524 corynanthine 62.1 µM 0.551484554161469 0.314371921043972 no 1046 0.290650776040501 1471 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2505 galangin 7.89 µM 0.551108503815043 0.314490723410639 no 1047 0.290779648156751 1359 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2652 actinonin 100 µM 0.551058842395018 0.314506413954322 no 1048 0.290796669077742 1399 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2345 9052315 157.45 µM 0.550604418197557 0.314650005001407 no 1049 0.290952439743729 1427 6469265 SGTC_1816 st051957 91.6 µM 0.550178017446262 0.31478476656737 no 1050 0.291098639787979 1414 674121 SGTC_1774 st048371 48.465 µM 0.550013657627528 0.314836718154382 no 1051 0.291155003006503 1365 4242727 SGTC_183 3914-0051 30.55 µM 0.548710964348533 0.315248608830465 no 1052 0.291601910264451 1493 1596232 SGTC_227 fluconazole 33.516 µM 0.548288011746975 0.315382389078231 no 1053 0.29174707885161 1356 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_491 tetrandrine 80.3 µM 0.547669009824109 0.315578223518926 no 1054 0.291959597472144 1473 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.546697305629915 0.31588574730716 no 1055 0.292293352797719 1461 688801 SGTC_249 wiskostatin 11.211 µM 0.545211828830014 0.31635611558495 no 1056 0.292803918476232 1436 2775510 A n-wasp and actin depolymerizer. SGTC_25 0118-0223 35.662 µM 0.543998638196151 0.316740486482075 no 1057 0.293221204981581 1463 5333628 SGTC_2754 granisetron 64.02 µM 0.543068646169138 0.317035266615215 no 1058 0.293541269643641 1502 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3061 glucosamine 200 µM 0.542813182237731 0.317116261515581 no 1059 0.293629218043542 1408 91431 and experimental redox chemotherapeutic SGTC_2883 9059145 45.46 µM 0.542332617584876 0.317268648395572 no 1060 0.293794694769586 1396 16476510 SGTC_1184 1269-1718 139 µM 0.539672570179881 0.318112708320684 no 1061 0.294711429891824 1521 5403821 SGTC_1387 3342-1166 1.8 µM 0.539022201912931 0.318319220758767 no 1062 0.294935767572531 1427 3418228 SGTC_594 1487-1584 10.8 µM 0.536438387826621 0.319140220594608 no 1063 0.295827803356507 1375 5013332 SGTC_2859 9028643 45.46 µM 0.535255220875614 0.319516465276736 no 1064 0.296236693084295 1401 17151580 SGTC_555 4296-0685 37 µM 0.532503860201454 0.320392110531477 no 1065 0.297188534478585 1462 2908540 YHR072W ERG7 SGTC_2820 7989630 71.43 µM 0.532355960801709 0.320439209233755 no 1066 0.297239740287067 1377 2984098 SGTC_3092 9117248 49.47 µM 0.530883899147871 0.320908146185159 no 1067 0.297749617893669 1516 17141857 SGTC_3159 9100096 49.47 µM 0.530454690522459 0.321044927862829 no 1068 0.297898357864339 1372 25236875 SGTC_3136 9095672 49.47 µM 0.528716543880299 0.321599094565502 no 1069 0.298501049444141 1363 17217380 SGTC_94 0334-0113 514.748 µM 0.527292299040348 0.322053477318138 no 1070 0.298995310626479 1383 6795178 SGTC_2031 5180455 200 µM 0.527033103131775 0.322136198309576 no 1071 0.299085300341621 1403 29949 SGTC_659 k018-0002 107 µM 0.525835537972241 0.32251850919486 no 1072 0.299501240174562 1473 6797879 YHR007C ERG11 SGTC_2917 7979103 53.79 µM 0.52575085135072 0.322545551677226 no 1073 0.299530663562396 1527 2980565 SGTC_3082 9117008 49.47 µM 0.525013421794036 0.322781070401528 no 1074 0.299786930294149 1445 41448529 SGTC_2990 9074105 71.4286 µM 0.524117044745311 0.323067449185865 no 1075 0.300098567041534 1455 6502001 SGTC_3172 9105863 49.47 µM 0.523301735098044 0.32332801929083 no 1076 0.300382146868613 1459 2348785 SGTC_31 0508-1974 57.237 µM 0.522012285215396 0.323740299881534 no 1077 0.300830888459273 1459 6810525 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.521964412471187 0.323755610580547 no 1078 0.300847554478616 1580 6728940 SGTC_2952 9073731 13.78 µM 0.521904251351696 0.323774851780425 no 1079 0.300868499061331 1416 16457353 SGTC_1783 st039459 87.517 µM 0.518566373712576 0.324843134687265 no 1080 0.30203158167459 1593 729761 SGTC_1797 st048695 56.8 µM 0.51684651657869 0.325394136023739 no 1081 0.302631652625398 1507 592262 YIL048W NEO1 SGTC_1889 st059080 5.18 µM 0.51444915910234 0.326162829361414 no 1082 0.303468998572379 1550 176925 Isolated from Daphnopsis sellowiana. SGTC_347 4534-1311 26.2 µM 0.512550657478076 0.326772093276853 no 1083 0.304132838145494 1435 2862016 SGTC_410 α-linolenic acid 100 µM 0.512492042275103 0.326790911331438 no 1084 0.304153344124429 1495 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2157 5649910 96.377 µM 0.510147134707017 0.327544090586616 no 1085 0.304974192738481 1425 2858091 SGTC_2720 fluspirilene 36.88 µM 0.510116770339457 0.327553848168901 no 1086 0.304984828413983 1490 3396 An atypical antipsychotic. SGTC_590 k048-0076 22.4 µM 0.509566668911759 0.327730643522785 no 1087 0.305177540027924 1522 6832814 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.509321135330465 0.327809567251738 no 1088 0.30526357283021 1440 2346 DNA damaging agent; causes G2/M arrest. SGTC_781 4335-2806 94.4 µM 0.507206764890985 0.328489523447826 no 1089 0.306004874452257 1599 845254 SGTC_2686 alizarin 95.37 µM 0.506658742146133 0.328665853838948 no 1090 0.30619714199243 1437 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_45 0kpi-0036 14.9 µM 0.505615806931442 0.329001531369555 no 1091 0.306563191394061 1497 2795021 SGTC_1359 1582-0056 520 nM 0.504047155953508 0.329506674692972 no 1092 0.307114120015626 1523 3661189 SGTC_1648 st011736 69.8 µM 0.503461417205691 0.329695376515408 no 1093 0.30731995012831 1536 2855514 SGTC_286 k060-0067 22.9 µM 0.501912126244398 0.330194705620064 no 1094 0.307864667490006 1461 5985051 SGTC_401 neomycin 50 µM 0.501684744033836 0.330268015308341 no 1095 0.307944648799732 1463 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3035 9091303 49.47 µM 0.501463613250771 0.330339315740249 no 1096 0.308022439931879 1488 25237002 SGTC_1191 1487-1166 10.6 µM 0.499839228349135 0.330863263912662 no 1097 0.308594143124604 1570 3955771 SGTC_3280 9140961 49.47 µM 0.499588510207235 0.33094416304119 no 1098 0.308682424914534 1475 4901226 SGTC_2967 9089538 49.85 µM 0.498243675550858 0.331378234997806 no 1099 0.309156150930292 1635 728216 SGTC_2927 9011802 47.9 µM 0.49769147172549 0.331556535357903 no 1100 0.309350760010981 1416 43912568 SGTC_1337 1486-1011 40.3 µM 0.496226589276729 0.33202971418312 no 1101 0.309867276668574 1470 X1337 SGTC_2465 5809242 33.21 µM 0.49616141887972 0.332050771422701 no 1102 0.309890264443601 1534 2731748 SGTC_2783 7738165 71.43 µM 0.49226503714714 0.333310695045499 no 1103 0.311265996498459 1400 17201110 SGTC_706 4262-0057 46.9 µM 0.492080175609963 0.333370518280745 no 1104 0.31133133304987 1443 883298 SGTC_1708 st033234 31.827 µM 0.491998111514796 0.333397076486887 no 1105 0.311360339284598 1554 674664 SGTC_530 4358-1714 28 µM 0.491927900389024 0.333419799407947 no 1106 0.311385156918683 1534 1564641 SGTC_1217 1183-1422 255 µM 0.490913149810147 0.333748278507452 no 1107 0.311743938033384 1582 2849664 SGTC_2781 5567276 71.43 µM 0.490468944399785 0.333892109822324 no 1108 0.311901050154877 1540 2853274 SGTC_2084 5306078 60.6385 µM 0.489836945318148 0.334096789776434 no 1109 0.312124642485357 1520 679340 SGTC_1802 st050112 57.9 µM 0.489236991147952 0.334291137292905 no 1110 0.312336961834059 1485 4662563 SGTC_356 1634-0012 32.5 µM 0.489090754830647 0.334338515422894 no 1111 0.312388723236435 1536 735457 SGTC_3276 9139060 49.47 µM 0.488359115603784 0.334575593958842 no 1112 0.3126477478141 1522 4870619 SGTC_2878 9043973 25.97 µM 0.48638137516167 0.335216785989466 no 1113 0.313348396602015 1570 6465167 SGTC_2982 9019404 25.97 µM 0.485143389263004 0.335618391000964 no 1114 0.313787317818115 1331 22333232 SGTC_62 0180-0423 3.232 µM 0.484196260372694 0.335925768301228 no 1115 0.314123295322467 1448 30102 YGL099W LSG1 SGTC_1559 coumarin 343 70.1 µM 0.481893007027071 0.336673714362546 no 1116 0.31494097702062 1566 108770 A hepatotoxic, DNA x-linker. SGTC_1692 fluoroquinolonic acid 71 µM 0.481147242548602 0.336916028599763 no 1117 0.315205926846446 1546 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1324 1418-0026 34.4 µM 0.480045025145058 0.337274285684741 no 1118 0.31559768878554 1532 1372513 SGTC_2116 5511452 16.8835 µM 0.479619654883278 0.337412584568521 no 1119 0.315748933918492 1529 870744 SGTC_1897 st060201 15 µM 0.478387697914437 0.337813249556405 no 1120 0.316187143973325 1468 611878 SGTC_2778 tioconazole 65.09 nM 0.477570818666098 0.338079021695676 no 1121 0.316477852356416 1466 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_832 4083-0019 164 µM 0.475924607316217 0.338614862657506 no 1122 0.317064045284222 1642 1990758 SGTC_1697 st025554 27.742 µM 0.475831604157313 0.338645144903133 no 1123 0.31709717613646 1505 1269519 SGTC_1540 guanosine 70.6 µM 0.475699832273498 0.338688052205486 no 1124 0.317144120222351 1513 6802 Guanosine is a purine nucleoside SGTC_1515 3460-0031 42.1 µM 0.471561388273443 0.340036667105749 no 1125 0.318619946184735 1495 2876596 SGTC_78 0336-0123 156.75 µM 0.470527431164743 0.340373928389658 no 1126 0.318989120372947 1477 6765896 SGTC_1907 st060210 83.7 µM 0.469923657233583 0.340570929461649 no 1127 0.319204780841364 1599 688793 SGTC_2641 levomentholum 100 µM 0.469913178214568 0.34057434896993 no 1128 0.319208524355865 1510 16666 SGTC_2192 5915882 198.485 µM 0.467771454088031 0.341273510006763 no 1129 0.319974018227391 1514 2876149 SGTC_883 0850-0245 24.6 µM 0.466288521212698 0.341757929729214 no 1130 0.320504497013531 1602 6823229 YPR165W RHO1 SGTC_2727 riluzole 51.77 µM 0.465668100474171 0.341960675800776 no 1131 0.320726544534985 1528 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1997 st073024 93.8 µM 0.464635090040775 0.342298352353779 no 1132 0.32109639952052 1530 686268 SGTC_1759 st043059 70 µM 0.463636446515296 0.342624914757678 no 1133 0.321454118717309 1483 669426 SGTC_3152 9099253 49.47 µM 0.463484076836651 0.342674750904838 no 1134 0.321508712885774 1582 25236131 SGTC_3006 9075424 71.4286 µM 0.463084412904597 0.342805483560845 no 1135 0.321651931085555 1491 7465181 SGTC_1395 3486-0190 4.35 µM 0.46300530414857 0.342831362778852 no 1136 0.321680282580497 1649 6748079 SGTC_3192 9110362 49.47 µM 0.461928573799351 0.343183671908982 no 1137 0.322066271192976 1580 16649480 SGTC_3206 9114350 49.47 µM 0.461214226725617 0.343417483491464 no 1138 0.322322457851382 1499 17087243 SGTC_399 oxolinic acid 75 µM 0.460918673636094 0.343514237945018 no 1139 0.322428476902859 1509 4628 A DNA gyrase inhibitor. SGTC_3012 9080433 71.4286 µM 0.460616494386907 0.343613172189239 no 1140 0.322536887783861 1629 17688859 SGTC_2537 larixol 68.93 µM 0.460272315873372 0.343725870148084 no 1141 0.322660384849437 1598 6708759 SGTC_682 0kpi-0099 17 µM 0.459489470717555 0.343982257009854 no 1142 0.322941355761309 1517 1714895 YML126C ERG13 SGTC_1921 5740136 50 µM 0.458707211721692 0.344238523573303 no 1143 0.323222217267045 1661 1774243 SGTC_1192 1488-0095 21.4 µM 0.45521749890143 0.345382616866395 no 1144 0.32447638628303 1553 915875 SGTC_1632 st005650 90 µM 0.454168959872384 0.345726654441586 no 1145 0.324853611174004 1551 2759605 SGTC_3286 9117135 37.221 µM 0.453311966671102 0.346007938315463 no 1146 0.325162058542394 1483 3438150 SGTC_3258 9138477 49.47 µM 0.453014460920499 0.346105606078751 no 1147 0.325269164282229 1586 4970355 SGTC_3025 9087895 49.47 µM 0.447432938597745 0.34793984795249 no 1148 0.327281248881745 1627 17173641 SGTC_428 3448-4153 16.5 µM 0.44739801580037 0.347951335808163 no 1149 0.327293854101545 1485 3834874 SGTC_1960 st011366 51.8 µM 0.447345795402075 0.347968513970757 no 1150 0.327312703176642 1546 3972846 SGTC_1674 st016616 23.6 µM 0.444582955556615 0.348877808209102 no 1151 0.328310583606268 1504 625830 SGTC_207 4185-0010 4.486 µM 0.44439246735224 0.348940532952826 no 1152 0.328379429258593 1588 3761753 SGTC_2685 mycophenolic acid 18.85 µM 0.444151126210279 0.349020008690254 no 1153 0.328466662390301 1607 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2058 5236698 133 µM 0.444136670304068 0.349024769356193 no 1154 0.328471887796995 1570 766665 SGTC_965 1291-5240 308 µM 0.441194567014155 0.349994165972165 no 1155 0.329536073046173 1653 2834598 SGTC_2512 diallyl trisulfide 49.23 µM 0.439368045397862 0.350596481168077 no 1156 0.330197438271251 1547 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_586 0957-0265 8.15 µM 0.439186719062227 0.3506562960112 no 1157 0.330263123726758 1533 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1654 st012436 41.8 µM 0.438293183637503 0.350951104164982 no 1158 0.330586883256616 1599 4323132 SGTC_3199 9111318 49.47 µM 0.43807336813026 0.351023642643468 no 1159 0.330666549644558 1631 8548020 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.435584365391426 0.351845384530624 no 1160 0.33156915816862 1664 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1088 bifonazole 369 nM 0.434999637840134 0.352038532377264 no 1161 0.331781345156956 1552 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2607 solasodine 47.35 µM 0.432789183845681 0.352769036590966 no 1162 0.332583965916146 1567 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1685 st024049 53.0905 µM 0.432442417816315 0.352883684145828 no 1163 0.33270994722238 1574 1941139 SGTC_1969 st069479 40.1 µM 0.427856084708265 0.354401267791791 no 1164 0.334377950686929 1663 3895485 SGTC_3039 9090270 49.47 µM 0.427699532013357 0.354453110905983 no 1165 0.334434945325388 1685 17173750 SGTC_745 0469-0705 296 µM 0.426955014371671 0.35469969809489 no 1166 0.334706046935744 1707 3486736 SGTC_1814 st052110 31.539 µM 0.422293266761827 0.356245068076945 no 1167 0.336405486103981 1694 674163 SGTC_3151 9099821 49.47 µM 0.421940440359513 0.356362126623544 no 1168 0.336534245601161 1553 17174189 SGTC_2966 9084041 48.03 µM 0.421644244445383 0.356460407110782 no 1169 0.336642353325888 1444 17741380 SGTC_1614 st002383 48.6 µM 0.420429394598602 0.356863604965205 no 1170 0.3370858991764 1597 1947235 SGTC_2175 5807670 165.306 µM 0.420073915399359 0.356981615618081 no 1171 0.33721572873103 1612 241186 SGTC_1909 st060837 51.5 µM 0.419596173445913 0.3571402361564 no 1172 0.337390242120131 1563 678937 SGTC_489 paxilline 115 µM 0.416337294170219 0.35822291119674 no 1173 0.338581603133278 1568 105008 A toxic potassium channel blocker. SGTC_1084 voriconazole 435 nM 0.4140776534344 0.358974286524907 no 1174 0.339408618917325 1667 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2796 7949634 45.45 µM 0.413781705821948 0.359072735466775 no 1175 0.339516991488943 1573 2971588 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.412867907376529 0.359376775641091 no 1176 0.339851697567068 1664 5393153 SGTC_1575 cyproterone acetate 48 µM 0.412509170179967 0.359496159489476 no 1177 0.339983130357914 1535 9880 An androgen receptor antagonist and liver toxin. SGTC_2285 7945142 200 µM 0.412486480106142 0.35950371096126 no 1178 0.3399914441164 1608 2970608 SGTC_2813 7971799 71.43 µM 0.411424063912355 0.359857354530794 no 1179 0.340380805872575 1635 2234054 SGTC_2634 4'-methoxyflavone 100 µM 0.411162234977453 0.35994452725517 no 1180 0.340476788941191 1599 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_467 ro 31-8220 72.8 µM 0.407582255918972 0.36113716628525 no 1181 0.341790196769919 1695 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2723 salbutamol 83.58 µM 0.407397896716289 0.361198620635976 no 1182 0.341857885752479 1665 9884233 β2-adrenoceptor agonist SGTC_1652 st011932 78 µM 0.406894762209423 0.361366353864855 no 1183 0.342042641549101 1693 1551076 SGTC_1082 camptothecin 424.86 nM 0.405177726285633 0.361938973816673 no 1184 0.342673438127898 1434 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2968 9090663 33.37 µM 0.403987435169204 0.362336109465842 no 1185 0.343110979417226 1625 25236811 SGTC_2929 9013348 24.6 µM 0.40395778495459 0.362346004029445 no 1186 0.343121881282445 1617 2995952 SGTC_1950 st077106 7.18 µM 0.402775349737029 0.362740669002797 no 1187 0.343556748378786 1587 13831864 SGTC_3263 9137018 49.47 µM 0.400021256159636 0.363660476027017 no 1188 0.344570430414063 1530 43844957 SGTC_1602 st001878 87.6 µM 0.400013569229804 0.36366304439639 no 1189 0.344573261261074 1678 595405 YLR310C CDC25 SGTC_1941 st076221 61.8 µM 0.399467129168701 0.363845637521567 no 1190 0.344774519711838 1751 2828568 SGTC_578 3460-0051 92 µM 0.39714356494213 0.364622402117748 no 1191 0.345630797885935 1733 2876744 SGTC_2483 5729050 27.16 µM 0.396722283556487 0.364763295604445 no 1192 0.345786132963174 1767 2865180 SGTC_656 4090-1979 187 µM 0.39593358783081 0.365027116361378 no 1193 0.346077011019692 1755 22330961 SGTC_173 1273-0061 2.693 µM 0.394182020416305 0.365613248583034 no 1194 0.346723329480755 1562 2847414 YPL266W DIM1 SGTC_1038 k292-0204 154 µM 0.393369233249245 0.365885340691577 no 1195 0.34702339507839 1578 4454212 SGTC_237 nikkomycin 200 µM 0.393279203936936 0.365915483442477 no 1196 0.347056638097905 1713 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_649 1123-0311 367 µM 0.393215452657802 0.365936828534913 no 1197 0.347080178754278 1688 693629 YIL048W NEO1 SGTC_1761 st044296 37 µM 0.3925630053308 0.366155303659334 no 1198 0.347321133921896 1599 1826700 SGTC_110 0850-0284 111.64 µM 0.392032878817178 0.366332851031382 no 1199 0.34751696027289 1578 3906265 SGTC_3296 9122258 64.045 µM 0.391959196087001 0.366357530755948 no 1200 0.347544181565013 1648 4730474 SGTC_1045 1348-1485 165 µM 0.391341695273912 0.366564381806955 no 1201 0.347772341488707 1606 6810614 SGTC_1403 3909-7815 62.9 µM 0.390057240223106 0.366994773985603 no 1202 0.348247110405122 1676 6615483 SGTC_3058 9093861 49.47 µM 0.389978618072674 0.367021123947418 no 1203 0.348276178987451 1665 17217477 SGTC_50 0929-0078 56.389 µM 0.389333106682224 0.367237488697407 no 1204 0.348514874435305 1690 1377751 SGTC_686 1319-0111 510 µM 0.389024106258538 0.367341075459732 no 1205 0.348629157011233 1743 4562600 SGTC_3310 9130229 44.1445 µM 0.388895027298452 0.367384349688808 no 1206 0.348676900419217 1718 7761258 SGTC_185 k048-0037 25.491 µM 0.38803265650485 0.367673506080541 no 1207 0.348995933466979 1758 6827589 SGTC_3284 9108171 64.8615 µM 0.386764167758847 0.36809897175764 no 1208 0.34946540335112 1655 8687505 SGTC_2443 5493264 126.67 µM 0.386607405052105 0.368151563014608 no 1209 0.34952343750848 1750 5340055 SGTC_1253 0550-0034 176 µM 0.386372314295205 0.3682304366489 no 1210 0.349610475603637 1647 5969915 SGTC_3153 9100258 49.47 µM 0.386290943556046 0.368257738063183 no 1211 0.349640603488231 1598 25236848 SGTC_2566 crystal violet carbinol 226 nM 0.384877669026181 0.368732024274345 no 1212 0.3501640256964 1546 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3306 9127676 59.7925 µM 0.383833628704343 0.369082526261961 no 1213 0.350550880789248 1619 41905287 SGTC_1117 retinoic acid 1.10837 µM 0.382532228760439 0.369519580655579 no 1214 0.351033314088876 1768 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_409 arachidonic acid 100 µM 0.38225492919172 0.369612729104928 no 1215 0.351136141034616 1662 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_624 k048-0052 28 µM 0.382239470937146 0.369617921954345 no 1216 0.351141873514021 1655 6835531 SGTC_1594 piperine 70.1 µM 0.381912412038223 0.369727795533656 no 1217 0.351263166710279 1607 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_90 0870-0863 4.608 µM 0.381685793605505 0.369803932948087 no 1218 0.351347219401408 1627 1738164 SGTC_836 0330-0104 1.35 µM 0.379043695666737 0.370691979418 no 1219 0.352327708083785 1691 46494820 SGTC_2773 thioridazine 9.09 µM 0.37863986616127 0.370827773073648 no 1220 0.352477656851353 1673 5452 An antipsychotic. SGTC_159 3970-0959 50 µM 0.375461867673804 0.371896982475082 no 1221 0.353658500358721 1712 6615653 SGTC_344 k064-0035 6.43 µM 0.37411187983141 0.372351473605393 no 1222 0.354160540293016 1607 5088750 SGTC_751 0833-0568 350 µM 0.372889983103267 0.3727629945378 no 1223 0.354615163775795 1696 6954252 SGTC_1187 1391-0724 117 µM 0.372627788783415 0.372851317550324 no 1224 0.354712743797662 1700 6997986 SGTC_652 0437-0092 114 µM 0.372272830472111 0.372970899773334 no 1225 0.354844862687173 1621 3091274 SGTC_647 0140-0236 81 µM 0.372219432140751 0.372988890244425 no 1226 0.354864739569674 1707 990837 SGTC_2600 tangeritin 87.95 µM 0.371747711397623 0.373147830053802 no 1227 0.355040349061699 1583 68077 A bioactive flavone. SGTC_2552 juarezic acid 87.02 µM 0.3696584221099 0.373852046543404 no 1228 0.355818507507641 1661 1549512 SGTC_2770 toltrazuril 17.5 µM 0.369481331819287 0.373911756052238 no 1229 0.355884492692015 1784 68591 Kills coccidiodes. SGTC_1465 k213-0056 144 µM 0.368032158450522 0.374400487209819 no 1230 0.356424627744235 1658 24048857 YMR208W ERG12 SGTC_2133 5320837 200 µM 0.367365900797237 0.37462524921797 no 1231 0.356673051660113 1722 2841355 SGTC_2395 5646831 180.19 µM 0.367202592379175 0.374680347813962 no 1232 0.356733952876941 1728 6808628 SGTC_3300 9124615 50.48 µM 0.366695155200189 0.374851568268798 no 1233 0.356923210398872 1749 24824903 SGTC_2620 irigenin 100 µM 0.36654319391561 0.374902848147378 no 1234 0.356979893857775 1766 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_182 3448-4371 550.524 µM 0.366010632795932 0.375082580253017 no 1235 0.357178570728079 1855 3491403 SGTC_2595 hexamethylquercetagetin 100 µM 0.365560539969776 0.375234501589604 no 1236 0.357346512236349 1679 386331 SGTC_570 0987-0065 62.6 µM 0.364350065751948 0.375643172962191 no 1237 0.357798309119242 1758 3104428 SGTC_1714 st033236 13.627 µM 0.363216871419385 0.376025880164146 no 1238 0.35822144272458 1785 2916566 SGTC_1221 2958-7315 257 µM 0.360999315975696 0.376775154949136 no 1239 0.359049979206557 1709 4562705 SGTC_2248 tofa 1.1 µM 0.360123180474304 0.377071314578766 no 1240 0.359377509317624 1705 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_189 3970-0742 2.116 µM 0.359055141174867 0.377432441168386 no 1241 0.359776919557656 1797 2891807 SGTC_2070 5230947 200 µM 0.357240259441673 0.37804633660671 no 1242 0.360455974501694 1769 2835538 SGTC_819 1013-0258 27.7 µM 0.35719288832605 0.378062364323736 no 1243 0.360473704753005 1679 5753198 SGTC_1474 0330-0125 5.35 µM 0.356638988984647 0.378249788225607 no 1244 0.360681042675496 1672 X1474 SGTC_469 w7 172 µM 0.355779538128859 0.378540658840313 no 1245 0.361002836989712 1740 45115570 A P450 inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.354661653415212 0.378919096190955 no 1246 0.361421540943287 1755 5377381 SGTC_319 1348-1596 45.5 µM 0.352457075607541 0.379665751541178 no 1247 0.362247752181028 1815 5380505 SGTC_303 1348-1668 34.2 µM 0.35237995637009 0.379691878739588 no 1248 0.362276665860573 1726 5380509 SGTC_699 0375-0592 111 µM 0.352371640313246 0.379694696166273 no 1249 0.362279783778103 1801 762578 SGTC_2147 5545932 89.7195 µM 0.352347957956554 0.379702719631714 no 1250 0.362288662992465 1703 797404 SGTC_2359 9039622 200 µM 0.347184705804862 0.38145323497098 no 1251 0.364226280038635 1773 6463596 SGTC_3155 9099265 49.47 µM 0.344419665705983 0.382391676704654 no 1252 0.365265350729976 1746 25236499 SGTC_1317 1273-0028 910 nM 0.344322099737069 0.382424802796433 no 1253 0.365302033037958 1695 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_952 1185-0122 232 µM 0.344043576369398 0.382519373193842 no 1254 0.365406757477201 1668 678600 SGTC_507 nimesulide 162 µM 0.343686861439774 0.382640503147705 no 1255 0.365540896502462 1821 4495 A COX2 inhibitor. SGTC_1915 st067105 30.6 µM 0.34076293209769 0.383633815779395 no 1256 0.36664102896065 1662 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_393 acivicin 6.25 µM 0.337833800934188 0.384629662911909 no 1257 0.367744218215566 1723 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2452 5863136 48.41 µM 0.337511648997346 0.384739234865296 no 1258 0.367865616083504 1685 2184096 SGTC_937 3122-0005 46.7 µM 0.336962184162495 0.384926142876117 no 1259 0.368072703677607 1850 759535 SGTC_2851 9015922 71.43 µM 0.335780973316974 0.385328038459912 no 1260 0.368518019537261 1802 2996893 SGTC_490 phenamil 164 µM 0.335190569131363 0.385528963982562 no 1261 0.368740667852587 1815 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1878 temozolomide 1 mM 0.334503055801968 0.385762976270239 no 1262 0.368999992689639 1863 5394 DNA alkylating agent. SGTC_2654 protoveratrine a 100 µM 0.33433676621966 0.385819583320173 no 1263 0.369062724826603 1753 5702278 A heart drug and vasodilator. SGTC_3294 9122953 26.2835 µM 0.333333218323831 0.386161255129238 no 1264 0.369441383584422 1674 16459826 SGTC_536 3852-0578 10.6 µM 0.333268155057923 0.386183409872075 no 1265 0.369465937636899 1829 2869208 SGTC_3043 9092303 49.47 µM 0.333118858480884 0.386234248367372 no 1266 0.369522282286526 1660 25236084 SGTC_2750 bromebric acid 70.15 µM 0.332779438685222 0.386349834919727 no 1267 0.369650390019185 1730 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_485 niflumic acid 177 µM 0.3325673965765 0.386422049193041 no 1268 0.369730428741357 1785 4488 A COX2 inhibitor. SGTC_681 1642-0006 26.6 µM 0.332156178638686 0.386562107136266 no 1269 0.369885665684925 1699 4446530 SGTC_2360 9040895 200 µM 0.332131240756889 0.386570601279225 no 1270 0.369895080549231 1693 4914414 SGTC_1895 st058434 18.3 µM 0.329047719937803 0.387621303216421 no 1271 0.371059809592244 1865 5393175 SGTC_1610 st001799 48.1 µM 0.327626045252934 0.388106013129491 no 1272 0.371597213328522 1670 621897 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.327384875545487 0.388188255551183 no 1273 0.371688402159049 1761 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_307 1501-1223 22.3 µM 0.326703810897509 0.388420535688995 no 1274 0.371945958805187 1743 2830329 SGTC_3181 9108277 49.47 µM 0.325465754911242 0.388842882371868 no 1275 0.37241429829676 1700 17097298 SGTC_2437 5741531 144.16 µM 0.324068862271381 0.389319571871532 no 1276 0.372942950099635 1861 2262990 SGTC_2829 7992743 58.44 µM 0.320911591477509 0.390397603103619 no 1277 0.374138694718107 1928 16462845 SGTC_264 promethazine 12.5 mM 0.319664801351387 0.390823544840292 no 1278 0.37461122260864 1848 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3220 9131269 49.47 µM 0.31882845353438 0.391109340354121 no 1279 0.374928300295136 1749 17722206 SGTC_689 0833-0039 98 µM 0.318523365939177 0.391213609074343 no 1280 0.375043986712077 1848 5374726 SGTC_2319 6033012 152.6 µM 0.315981202480919 0.392082738728601 no 1281 0.376008387989997 1684 847246 SGTC_387 norethindrone acetate 66.7 µM 0.315247962771242 0.392333523283665 no 1282 0.376286695829711 1718 541197 SGTC_2726 cimetidine 79.27 µM 0.314212984920427 0.392687585196156 no 1283 0.376679640610969 1803 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1358 1509-0022 2.48 µM 0.313677837077382 0.392870692055651 no 1284 0.376882867624273 1799 3258434 SGTC_2587 piperic acid 92.2 µM 0.311309599412332 0.393681295335021 no 1285 0.377782635172512 1722 5370536 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.310705373061688 0.393888184613194 no 1286 0.378012306093315 1929 688664 SGTC_1288 0973-0013 65.5 µM 0.307467017174378 0.394997518409301 no 1287 0.37924396220054 1792 4315430 SGTC_1409 3909-8004 61.9 µM 0.305965427892969 0.395512193624091 no 1288 0.379815484389459 1783 2119279 SGTC_788 1182-0090 188 µM 0.303492058501906 0.396360347051273 no 1289 0.380757449332177 1912 5715185 SGTC_402 epigallocatechin gallate 10 µM 0.303468296835735 0.396368497649631 no 1290 0.380766502230605 1747 65064 An antioxidant. SGTC_1161 k007-0610 110 µM 0.303110920131634 0.396491088537219 no 1291 0.380902666168797 1838 5843850 SGTC_1827 berberine 7.24 µM 0.303021499805613 0.396521763981928 no 1292 0.380936738474997 1640 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1321 1326-2144 215 µM 0.301556339784883 0.397024474975104 no 1293 0.381495147567617 1890 3513030 SGTC_2511 berberine 10.47 µM 0.295854671326192 0.398982395942682 no 1294 0.383670534584803 1756 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_924 2046-0044 21.3 µM 0.295687552940073 0.399039822079577 no 1295 0.383734351842496 1718 3623589 SGTC_2076 5212012 200 µM 0.295552552311284 0.399086213332132 no 1296 0.3837859066412 1794 604802 SGTC_646 4092-0839 27.3 µM 0.295516541116923 0.399098588362837 no 1297 0.383799659146033 1876 877796 SGTC_1896 st058441 89 µM 0.294924115962077 0.399302186258104 no 1298 0.38402592450752 1747 688759 SGTC_247 mechlorethamine 29.705 µM 0.294155180686512 0.399566485973901 no 1299 0.384319663455551 1809 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3227 9130768 49.47 µM 0.29415459477957 0.399566687380378 no 1300 0.38431988730168 1839 17720899 SGTC_3020 9089140 49.47 µM 0.29204218623768 0.400293004647067 no 1301 0.385127184622816 1766 17217859 SGTC_2195 6536160 144.242 µM 0.291285331152466 0.400553321013178 no 1302 0.385416552662897 1772 3834386 SGTC_2413 inermin 26.06 µM 0.290923211671438 0.400677885755088 no 1303 0.385555024204515 1927 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2497 7-hydroxyflavone 100 µM 0.290791452457496 0.400723211845331 no 1304 0.385605411475953 1891 5281894 SGTC_1862 st057513 3.81 µM 0.288024974781619 0.401675207268521 no 1305 0.386663810626711 1777 5393163 SGTC_942 3253-1115 227 µM 0.286785233459504 0.402102014641328 no 1306 0.387138385114203 1892 46497897 SGTC_1767 st044992 70.3 µM 0.286488560800585 0.402204167859845 no 1307 0.387251976818776 1742 9600693 SGTC_2364 9055074 200 µM 0.286307420102249 0.402266543273658 no 1308 0.387321337741045 1747 6470630 SGTC_630 4356-0227 183 µM 0.284999027317173 0.402717159360752 no 1309 0.387822443563136 1820 779312 SGTC_592 k241-0073 46.5 µM 0.284651964881599 0.402836710868886 no 1310 0.387955397585765 1913 4230158 SGTC_325 2810-4341 181 µM 0.284232033438379 0.402981375481043 no 1311 0.388116284110653 1919 774970 SGTC_2091 4-phenylthiadiazole 200 µM 0.283295071881277 0.403304202637601 no 1312 0.388475327344582 1796 270010 SGTC_2826 7992541 19.48 µM 0.28255824674751 0.403558119725495 no 1313 0.388757745359315 1853 2985066 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.282524643488489 0.403569700704647 no 1314 0.388770626569691 1905 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1432 4049-0298 68.4 µM 0.281889468731076 0.403788622318125 no 1315 0.3890141324788 1936 741646 SGTC_2847 9005661 71.43 µM 0.281879388797647 0.403792096747344 no 1316 0.389017997158125 1861 2991449 SGTC_895 0964-0006 13.7 µM 0.281522746665884 0.403915031792635 no 1317 0.38915474197838 1919 6738897 SGTC_2684 capsaicin 100 µM 0.280636144485043 0.404220685914984 no 1318 0.389494745165469 1837 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2722 naftopidil 47.16 µM 0.280066021118914 0.404417265576449 no 1319 0.389713426561678 1893 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.279469799902254 0.40462286964332 no 1320 0.38994215562611 1910 23847180 SGTC_801 0866-0028 10.1 µM 0.279454353941996 0.404628196459915 no 1321 0.389948081685302 1817 6849771 SGTC_907 3448-6986 75.5 µM 0.278589563295635 0.404926463205972 no 1322 0.390279911510127 1904 590582 SGTC_2140 5586273 200 µM 0.278433297442094 0.404980365278428 no 1323 0.390339880998368 1819 854421 SGTC_2804 7954240 19.48 µM 0.277690946807073 0.405236455026693 no 1324 0.390624805391898 1907 828705 SGTC_2822 7994718 71.43 µM 0.277396292797744 0.405338113492868 no 1325 0.390737913950292 1850 1018011 SGTC_1667 st014849 34.6 µM 0.276250694175954 0.405733416656974 no 1326 0.39117776158676 1856 5348460 SGTC_2368 9071271 200 µM 0.275086336466968 0.406135291404557 no 1327 0.391624954350584 1755 27209959 SGTC_1882 5615643 20 µM 0.272864852693948 0.406902304266498 no 1328 0.392478552542012 1909 2253075 SGTC_302 1094-0063 18.9 µM 0.272567532381167 0.407004987374722 no 1329 0.392592836299262 1822 5440289 SGTC_864 0469-0573 172 µM 0.272092825505868 0.407168946291597 no 1330 0.392775322964622 1769 689425 SGTC_2328 6201408 200 µM 0.27196223339665 0.407214054329676 no 1331 0.392825529277498 1788 2890418 SGTC_1362 1611-0397 101 µM 0.271904607780224 0.407233959281232 no 1332 0.392847684090685 1798 27816 SGTC_2019 4016004 108 µM 0.26931622276979 0.408128281542572 no 1333 0.39384317463175 1771 45595336 SGTC_1799 st045822 46.1415 µM 0.26846705914923 0.408421783670359 no 1334 0.394169913724488 1931 3674992 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.266915661113775 0.408958136366041 no 1335 0.394767049073705 1820 16486 A toxic proline analog. SGTC_1441 4106-0040 13 µM 0.26593665172357 0.409296689437779 no 1336 0.395143998569625 1867 2904180 SGTC_981 1488-1094 54.9 µM 0.265680159377737 0.409385398732411 no 1337 0.395242772453185 1833 3449522 SGTC_2728 chlorpromazine 9.18 µM 0.264651587354385 0.409741182617145 no 1338 0.395638937809211 1873 2726 A thorazine and dopamine antagonist. SGTC_2692 st077426 47.7 µM 0.263526224314646 0.41013053173941 no 1339 0.396072506789303 1937 25238571 SGTC_589 1227-0070 34.1 µM 0.263458530941043 0.410153954882468 no 1340 0.396098591142661 1875 2841384 SGTC_3323 9138564 53.9225 µM 0.262594883277526 0.410452820846324 no 1341 0.396431422125577 1950 43912313 YNL103W MET4 SGTC_2108 5365811 200 µM 0.262236224693017 0.410576950229822 no 1342 0.396569663523628 1911 780283 SGTC_2680 butyl paraben 22.24 µM 0.262049175744224 0.410641690198811 no 1343 0.39664176484771 1911 7184 An antifungal and steroid mimetic. SGTC_1438 4092-1045 4 µM 0.261641337630288 0.410782856484738 no 1344 0.396798985509427 1841 1351342 SGTC_1706 st031321 9.9705 µM 0.261272023553153 0.410910698296368 no 1345 0.396941369718736 1942 6103185 SGTC_2614 arthonioic acid 13.39 µM 0.260333001684874 0.411235792826249 no 1346 0.397303459148586 1836 6710684 SGTC_517 1365-0151 113 µM 0.260229582518115 0.411271600840828 no 1347 0.397343343282595 1863 768657 SGTC_1444 4112-3581 28 µM 0.258673781778382 0.411810372772362 no 1348 0.397943475157327 1867 2877249 SGTC_1442 4112-3290 3 µM 0.25769410952812 0.412149717493333 no 1349 0.39832149626399 1873 704353 SGTC_854 0422-0053 192 µM 0.25723542996349 0.412308620253812 no 1350 0.398498517420683 1858 3596728 SGTC_1366 1683-0113 21.9 µM 0.257216290275566 0.412315251228637 no 1351 0.398505904577863 1810 708623 SGTC_441 propafenone 146 µM 0.256516220705245 0.41255780861294 no 1352 0.398776128519149 1848 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1320 1313-0481 95.3 µM 0.256034132809569 0.41272485997708 no 1353 0.398962240665285 1973 6813365 YLR208W SEC13 SGTC_3098 9119039 49.47 µM 0.255171159686894 0.413023933777818 no 1354 0.399295452566619 1844 17161528 SGTC_979 1426-2828 121 µM 0.254868289823843 0.413128908979209 no 1355 0.399412414339229 1921 747872 SGTC_2324 6149169 200 µM 0.254780404739088 0.413159371259691 no 1356 0.399446355343486 1938 2888231 SGTC_978 1416-0512 87.4 µM 0.253844650115748 0.413483750146078 no 1357 0.399807788561745 1859 6814003 SGTC_346 4513-0042 7.16 µM 0.252633004521096 0.413903854217095 no 1358 0.400275911602018 1822 2827372 SGTC_1500 4488-1866 171 µM 0.252475361051931 0.413958519916557 no 1359 0.400336828196024 1955 2900003 SGTC_383 2324-0395 7.37 µM 0.250692100778536 0.414577013245936 no 1360 0.401026084184351 1918 3146421 SGTC_974 1326-0144 138 µM 0.250338577531875 0.414699651948494 no 1361 0.401162762723479 1826 5411856 SGTC_3057 9095946 49.47 µM 0.248414553060835 0.415367249603792 no 1362 0.401906837351635 1896 24540043 SGTC_3030 9087619 49.47 µM 0.248070271679148 0.415486734128359 no 1363 0.402040018285346 1838 25236973 SGTC_2845 9003024 42.97 µM 0.24794481476492 0.415530276502757 no 1364 0.402088552547376 1947 2990173 SGTC_3356 9151811 4.48 µM 0.246416337016337 0.416060848945185 no 1365 0.402679980481616 1855 1859254 YPR165W RHO1 SGTC_2113 5491891 107.031 µM 0.245068639661389 0.41652879501704 no 1366 0.403201642269797 1809 789979 SGTC_968 1309-0633 340 µM 0.244095677756339 0.416866699420286 no 1367 0.403578359985735 1998 3761976 SGTC_2965 9082772 38.63 µM 0.244079501619522 0.416872317824852 no 1368 0.403584623924678 2010 16459634 SGTC_2499 avocadenofuran 51.48 µM 0.243522481962532 0.417065795986922 no 1369 0.403800335566229 1780 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_54 0159-0055 9 µM 0.243002668748243 0.417246368785745 no 1370 0.404001665024015 2008 3319099 SGTC_2131 toluylene red 5.2905 µM 0.24251810132486 0.417414713617467 no 1371 0.404189366299276 1829 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1076 itraconazole 331 nM 0.239807489646896 0.418356692645886 no 1372 0.405239750237036 1982 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2095 5432005 200 µM 0.239158588212323 0.418582265518717 no 1373 0.405491306385686 1881 783734 SGTC_1022 4477-0945 21.3 µM 0.237617062357082 0.419118242134588 no 1374 0.406089057825916 1828 4648966 SGTC_2033 5192550 145 µM 0.236559982602985 0.419485867426749 no 1375 0.406499084155195 1844 182073 SGTC_2698 st077697 67.5 µM 0.236114562044382 0.419640794367636 no 1376 0.406671887241578 1791 3154499 SGTC_906 1165-0455 526 µM 0.235898364207092 0.41971599716129 no 1377 0.406755768804736 1844 3252859 SGTC_1830 st055982 50.3 µM 0.235653625396579 0.419801131256152 no 1378 0.40685072900573 2013 455313 An antimicrobial agent. SGTC_1603 st002045 67.8 µM 0.234647677392914 0.420151096632912 no 1379 0.40724110063292 2006 5887985 SGTC_1257 0669-0121 16 µM 0.233849551057243 0.420428806600455 no 1380 0.407550889854357 1967 4307855 SGTC_996 3970-0799 1.8 µM 0.230081789971376 0.421740340740161 no 1381 0.409014107415053 2012 6615648 YGL040C HEM2 SGTC_2560 caryophyllene 100 µM 0.228043195474873 0.422450325821921 no 1382 0.40980632997868 1884 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2164 5685496 200 µM 0.22749517578403 0.422641228733817 no 1383 0.410019360036541 1992 759046 SGTC_205 1486-1330 71.903 µM 0.226195854082171 0.423093920580969 no 1384 0.41052454751039 1915 4118834 SGTC_520 3584-0023 682 µM 0.225431665407321 0.423360216188003 no 1385 0.410821740056441 1853 1340790 SGTC_111 0083-0039 52.457 µM 0.221574538627849 0.424704834908339 no 1386 0.412322552526562 2014 759313 SGTC_1670 st016595 4.04 µM 0.22098178839563 0.424911549477747 no 1387 0.412553306607038 2034 597879 SGTC_2205 7238770 200 µM 0.220830502926507 0.424964311789547 no 1388 0.412612205970253 2015 279867 SGTC_1137 ixabepilone 100 µM 0.220247111325159 0.425167787990064 no 1389 0.412839353889491 1835 154225 A novel microtubule stabilizer. SGTC_2900 5328528 85.29 µM 0.218523935461641 0.425768916068135 no 1390 0.413510455558821 1923 795359 SGTC_734 2023-0417 80 µM 0.218000926054788 0.425951401546455 no 1391 0.413714194945703 1966 3935732 SGTC_2311 7694451 200 µM 0.217230842884492 0.426220123457731 no 1392 0.414014224693497 1956 2163142 SGTC_92 0063-0024 660.874 µM 0.214240683944822 0.427263868487125 no 1393 0.415179685667802 2053 3594437 SGTC_2970 9090938 41.86 µM 0.213863484351166 0.427395570126684 no 1394 0.415326758333228 2059 17217104 SGTC_1803 st050068 52.4 µM 0.213567969769012 0.427498756578177 no 1395 0.415441989751639 1983 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_983 1491-0821 12.2 µM 0.213090048470853 0.427665645479217 no 1396 0.415628363283438 2024 46495113 SGTC_525 k781-2675 26.7 µM 0.212781972397161 0.427773231722648 no 1397 0.41574851284772 2061 3651118 YDL195W SEC31 SGTC_1467 k284-1082 293 µM 0.212221320241733 0.427969036291329 no 1398 0.415967187200346 2055 3334705 SGTC_737 1950-0117 57.9 µM 0.212210322739104 0.427972877283963 no 1399 0.415971476879336 2049 5393513 SGTC_2023 5144124 124 µM 0.211098426949896 0.42836125366567 no 1400 0.416405233843167 1919 2830192 SGTC_350 k064-0020 19.8 µM 0.209940003520191 0.42876595559199 no 1401 0.416857249803967 2064 2790705 SGTC_722 3534-0461 190 µM 0.209885812997518 0.428784889201911 no 1402 0.416878397601972 1876 658262 SGTC_2849 9019321 12.99 µM 0.209183141011213 0.429030410374095 no 1403 0.417152636410347 1941 16489627 SGTC_1573 oleylamine 1.06 µM 0.207856214102432 0.429494127770925 no 1404 0.41767061925404 1896 5356789 An amine of the fatty acid oleic acid. SGTC_980 1473-0395 201 µM 0.206559354363795 0.429947431706437 no 1405 0.418177003065463 1893 768876 SGTC_1400 3771-8998 51.5 µM 0.205827223173543 0.430203381433198 no 1406 0.418462937727071 1984 670767 SGTC_508 roscovitine 141 µM 0.20528993274973 0.430391234382898 no 1407 0.418672804531649 1974 160355 A CDKinase inhibitor. SGTC_256 clotrimazole 625 nM 0.205110480970725 0.430453979653234 no 1408 0.418742903945631 2011 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2788 5282734 71.43 µM 0.204698616869325 0.430597994472182 no 1409 0.418903800552753 2032 743706 SGTC_2265 7929201 200 µM 0.204260515463964 0.430751193712019 no 1410 0.419074961772061 1928 1265108 SGTC_756 0508-1999 28.3 µM 0.200909571374037 0.431923325039913 no 1411 0.420384641719253 1849 6753853 SGTC_2302 7771753 200 µM 0.200020164622852 0.432234532956474 no 1412 0.420732405348355 1871 2203047 SGTC_2092 5303694 80.6725 µM 0.198888742475948 0.432630484030022 no 1413 0.421174887900528 1921 1963699 SGTC_2640 pentamidine 10.38 µM 0.198125533707465 0.432897613849893 no 1414 0.421473423895196 2082 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2776 terbinafine 19.92 µM 0.196781721654989 0.433368034417465 no 1415 0.421999177723594 2052 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1189 1431-2119 7.28 µM 0.19513663331804 0.433944049525003 no 1416 0.422642992274867 1997 3107275 SGTC_432 NS 1619 61.3 µM 0.194801681336773 0.434061347632005 no 1417 0.422774102995014 1946 4552 A K+/calcium channel activator. SGTC_1472 k841-0093 193 µM 0.192427462918622 0.434892950053513 no 1418 0.423703691029814 2046 X1472 SGTC_693 4161-2696 114 µM 0.192403021266713 0.434901512580338 no 1419 0.423713262993502 2041 805759 SGTC_3149 9097855 49.47 µM 0.192300909166862 0.434937285353276 no 1420 0.423753253138754 2055 25236625 YMR079W SEC14 SGTC_170 4197-0004 226 µM 0.191735464212797 0.435135386435849 no 1421 0.423974712458034 1988 218692 SGTC_2504 purpurogallin 52.29 µM 0.19132866315265 0.43527791742123 no 1422 0.424134052964852 1912 5281571 An antioxidant. SGTC_2135 5326629 150.42 µM 0.189957457244185 0.435758409004164 no 1423 0.424671233838325 1921 5020077 SGTC_2373 9071805 200 µM 0.188135757719658 0.436396907049141 no 1424 0.425385115474259 2123 10149009 SGTC_2536 dehydroabietamide 32.04 µM 0.184975320436385 0.437505019382281 no 1425 0.426624196478611 2066 3983547 SGTC_2541 muurolladie-3-one 83.07 µM 0.184216245033057 0.437771239714128 no 1426 0.426921907937949 2018 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2412 st077135 33.4 µM 0.183550402486711 0.438004784934115 no 1427 0.427183087496939 2046 13258915 SGTC_2576 guaiol 23.12 µM 0.180710864908868 0.439000998223668 no 1428 0.428297265117036 2113 227829 SGTC_184 1494-0393 24.714 µM 0.180602575806005 0.439038997679444 no 1429 0.428339766965576 1940 3090647 SGTC_2687 chenodiol 100 µM 0.180142880640313 0.439200314400432 no 1430 0.428520199670846 1992 5702181 A cholesterol synthesis inhibitor. SGTC_2938 9059746 27.26 µM 0.179930844782579 0.439274725655942 no 1431 0.428603429868091 2023 6471769 SGTC_1430 4049-0248 69.1 µM 0.178743204769255 0.439691552230954 no 1432 0.429069671470839 2085 22774488 SGTC_2482 5981709 142.65 µM 0.177229229508204 0.440223009730772 no 1433 0.429664168620325 2016 877755 SGTC_2386 9075165 157.42 µM 0.175203423174797 0.440934305909626 no 1434 0.430459897316579 2028 16452277 SGTC_777 1315-0167 517 µM 0.175200857211439 0.440935206985763 no 1435 0.430460905396606 1941 4221767 SGTC_2394 5221648 200 µM 0.175098387986209 0.440971190825725 no 1436 0.430501162452212 2050 788586 SGTC_1338 1486-1223 76 µM 0.174830561680156 0.44106524496424 no 1437 0.43060638670766 2059 3444526 SGTC_960 1222-0186 7.7 µM 0.174490450885528 0.441184688461925 no 1438 0.43074001737049 2029 3126296 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.174384016574224 0.441222068223448 no 1439 0.430781837395485 1961 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3184 9108758 49.47 µM 0.174256961448197 0.441266690706752 no 1440 0.430831760739295 2029 902885 SGTC_674 0498-0004 451 µM 0.174132967734077 0.441310238723632 no 1441 0.430880482238513 1937 4231473 SGTC_2292 7671323 168.05 µM 0.173913784359455 0.441387220178295 no 1442 0.430966609682285 1975 937504 SGTC_429 1112-0049 25.5 µM 0.173362177152672 0.441580965126208 no 1443 0.431183376584183 1905 2836170 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.173182493413464 0.441644079752878 no 1444 0.431253991974617 2067 229346 A bile salt which induces apoptosis. SGTC_88 0180-0332 8.668 µM 0.172719879123692 0.441806581673111 no 1445 0.431435808675428 2072 3101745 SGTC_2460 5552655 174.22 µM 0.171701532197784 0.442164329548072 no 1446 0.431836090592688 1953 5401989 SGTC_1123 mangostin 811.285 nM 0.170299192141251 0.442657052342744 no 1447 0.432387423279644 1952 5281650 An antioxidant. SGTC_839 0122-0028 230 µM 0.169597654653184 0.442903576185748 no 1448 0.432663283572307 2028 759448 SGTC_230 MPP+ 141.667 µM 0.169092866448526 0.4430809750108 no 1449 0.4328617979427 1963 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1295 1013-0063 9.78 µM 0.168975308344414 0.443122290352335 no 1450 0.432908031594151 2124 6826038 SGTC_2884 9058502 51.95 µM 0.168938626225951 0.443135182267765 no 1451 0.432922458250624 2008 6471554 SGTC_731 3966-0296 387 µM 0.168922396949171 0.443140886059616 no 1452 0.432928841067572 2027 660956 SGTC_729 4092-0585 94.1 µM 0.168460695782852 0.443303156221856 no 1453 0.433110430976112 1952 2169061 SGTC_2094 5332512 191.667 µM 0.164163419115888 0.444813935874221 no 1454 0.434801248843727 2105 755774 SGTC_2234 tolnaftate 200 µM 0.163838115191364 0.444928334851107 no 1455 0.43492929275148 2122 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1851 st056236 18.9 µM 0.163379510843151 0.445089619109115 no 1456 0.435109817050314 2145 5393171 SGTC_1732 st034308 51.822 µM 0.163108970367132 0.445184768393777 no 1457 0.435216318526287 1901 830119 SGTC_1365 1672-3266 55.4 µM 0.161713039148576 0.445675768497046 no 1458 0.435765917971925 2114 6415873 SGTC_212 3807-4682 38.772 µM 0.160488666899346 0.446106493655509 no 1459 0.436248074209347 2093 3125501 YBL034C STU1 SGTC_2096 5468907 200 µM 0.16040309463034 0.446136599734701 no 1460 0.436281776010972 2123 759785 SGTC_2594 a-mangostin 100 µM 0.160239113737686 0.446194292443258 no 1461 0.436346359574916 2104 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2492 derrusnin 100 µM 0.160165242390688 0.446220282661156 no 1462 0.436375454219541 2009 1715307 Part of coumarin class of compounds. SGTC_634 1611-4317 11.2 µM 0.159169762222289 0.446570545774421 no 1463 0.43676756318449 2152 2843522 SGTC_2905 7799065 20.05 µM 0.158229556856116 0.446901398544708 no 1464 0.437137957059311 2119 1296806 SGTC_2171 5739187 198.077 µM 0.157328124610124 0.447218641989384 no 1465 0.437493128013741 2024 2262761 SGTC_1062 mesoridazine 14.2 µM 0.156341424455806 0.447565932705987 no 1466 0.437881952889826 2113 4078 A neuroleptic. SGTC_700 3453-2283 142 µM 0.156206023701726 0.447613593107978 no 1467 0.437935314397574 2099 565664 SGTC_85 0868-0259 160.055 µM 0.15586767161837 0.447732694688611 no 1468 0.438068664061887 2041 83173 SGTC_2121 5257820 149.641 µM 0.155697730060744 0.447792516722826 no 1469 0.438135643249598 2152 791256 SGTC_574 1315-0397 40 µM 0.155024044124276 0.448029676174317 no 1470 0.438401180989846 2106 6794277 SGTC_2025 5147754 141 µM 0.153399275130423 0.448601724192653 no 1471 0.43904170824186 2122 315777 YLR208W SEC13 SGTC_614 0462-0418 107 µM 0.153173765345553 0.448681130061176 no 1472 0.439130622866531 2098 5188303 SGTC_244 nsc-207895 1.295 µM 0.151774201323537 0.449173986441771 no 1473 0.439682515367967 2057 42640 SGTC_2992 9074591 71.4286 µM 0.151057895843749 0.449426263761791 no 1474 0.439965022772151 2158 17741321 SGTC_750 4073-0104 132 µM 0.150646810024061 0.449571054287995 no 1475 0.440127166839304 2131 22330957 SGTC_2759 disulfiram 3.38 µM 0.150622296036268 0.449579688690609 no 1476 0.440136836178459 2050 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2017 5132927 60.65 µM 0.150452290956937 0.449639569131538 no 1477 0.440203894253947 2039 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2228 7354201 200 µM 0.150207203437883 0.449725897680285 no 1478 0.440300571427013 2097 753451 SGTC_2941 9056145 11.23 µM 0.149773907816455 0.449878525641663 no 1479 0.440471497834668 2168 2119517 SGTC_2111 5486399 200 µM 0.149685641068641 0.449909618427547 no 1480 0.440506318652398 2098 689674 SGTC_964 1287-0107 19.4 µM 0.149481674693738 0.449981468663083 no 1481 0.440586784189409 2124 51516812 YPR165W RHO1 SGTC_1458 k015-0034 6.33 µM 0.149285664328483 0.450050517819073 no 1482 0.440664113361057 1959 3598957 SGTC_1785 bathophenanthroline 24 µM 0.149221954998432 0.450072961220515 no 1483 0.440689248181094 1964 72812 An iron chelator. SGTC_631 k072-0230 41.5 µM 0.14876185445978 0.450235049298254 no 1484 0.440870775687419 2092 5773147 SGTC_880 0833-0487 87.2 µM 0.148076887522791 0.450476370567961 no 1485 0.441141044715376 2058 76075 SGTC_42 0133-0086 60.653 µM 0.14785919642693 0.450553069337086 no 1486 0.441226945353752 2097 162923 Model of phenazepam hydroxylation. SGTC_1848 st056003 16.4 µM 0.146059605701817 0.451187186837761 no 1487 0.441937167174681 2199 146492 SGTC_2803 7707263 71.43 µM 0.145794920569309 0.451280463856631 no 1488 0.442041642928248 2024 2199229 SGTC_2744 captopril 92.04 µM 0.145089845037418 0.451528950857658 no 1489 0.442319967967785 2156 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_697 0508-1955 564 µM 0.144880055390552 0.451602889869837 no 1490 0.442402786884183 2151 6243113 SGTC_2736 butenafine 14.65 µM 0.143937846618381 0.451934985960382 no 1491 0.44277477478704 2129 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2961 9083290 32.55 µM 0.143366324695645 0.45213644412739 no 1492 0.443000438599234 2162 17741490 SGTC_1371 2421-0008 32.7 µM 0.143355303076664 0.452140329305527 no 1493 0.443004790636234 2024 2827552 SGTC_2065 5221596 34.26 µM 0.143192357919471 0.45219776885728 no 1494 0.44306913256221 2079 788581 SGTC_1986 st071812 45 µM 0.142327696222364 0.452502586161697 no 1495 0.443410585395242 2158 11838594 SGTC_1151 3909-8316 15.3 µM 0.141735697162028 0.452711298456947 no 1496 0.443644388656688 2057 800431 SGTC_927 2425-1185 123 µM 0.140552510407538 0.453128476092782 no 1497 0.444111733448412 2010 730375 SGTC_2981 9013952 38.96 µM 0.140158705727628 0.453267338456683 no 1498 0.444267298916897 1919 2996344 SGTC_1493 4348-0038 111 µM 0.139758487343699 0.453408468258681 no 1499 0.44442540680148 2152 800424 SGTC_2010 4012422 159 µM 0.138610503102344 0.453813316803473 no 1500 0.444878971580092 2103 952393 SGTC_2585 alliin 100 µM 0.138169538253219 0.453968840411876 no 1501 0.445053214553666 2098 87310 A garlic compound which reacts with lipids. SGTC_144 4161-2749 112.381 µM 0.137174699842116 0.45431973521884 no 1502 0.445446354223702 2078 797501 YMR168C CEP3 SGTC_1268 0828-0275 2.46 µM 0.137138224139006 0.454332601439541 no 1503 0.445460769693046 2103 745337 SGTC_2601 securinine 100 µM 0.136872568277852 0.454426308738884 no 1504 0.445565761040411 2052 442872 A GABA receptor antagonist. SGTC_1884 5633444 25 µM 0.136845893445038 0.454435718144661 no 1505 0.445576303562183 2092 5724239 SGTC_2227 7312221 64.1025 µM 0.136773485188974 0.454461259901785 no 1506 0.445604921203244 2149 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_596 1155-0152 116 µM 0.136418922846039 0.454586333235192 no 1507 0.445745057625423 2085 280313 SGTC_2305 7443522 69.23 µM 0.136279384520158 0.454635557192374 no 1508 0.445800210298909 2088 5415886 SGTC_2529 gangaleoidin 93.61 µM 0.1351482466423 0.455034606420433 no 1509 0.446247332380813 2086 4565183 SGTC_550 4123-0385 25.7 µM 0.134913281496124 0.455117504461117 no 1510 0.44634021922284 2059 5731123 SGTC_2839 9003951 25.97 µM 0.134269337178265 0.455344704429114 no 1511 0.446594799520834 2234 2990634 SGTC_2902 5787006 60.46 µM 0.133546069628968 0.455599909067285 no 1512 0.446880766119732 2064 591003 SGTC_165 k038-0023 64.381 µM 0.133355925586877 0.455667004355105 no 1513 0.446955950145278 2105 46368543 SGTC_153 4077-0274 519.67 µM 0.133328219447976 0.455676781003484 no 1514 0.446966905467899 2182 3121976 SGTC_3211 9128781 49.47 µM 0.132903318381709 0.455826718942804 no 1515 0.447134921249318 1919 17194361 SGTC_2225 6654152 15.4 µM 0.128791125136295 0.457278140489086 no 1516 0.448761464079118 2154 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_511 blebbistatin 171 µM 0.128118968813771 0.457515436527167 no 1517 0.449027412407314 2163 3476986 A myosin inhibitor. SGTC_771 0250-0039 27.3 µM 0.127287595413096 0.457808963025795 no 1518 0.449356388936126 2062 3005115 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.12597862766173 0.458271156602605 no 1519 0.449874421214408 2206 5024745 SGTC_2714 st079313 56.9 µM 0.124661790282318 0.45873618586422 no 1520 0.450395654149612 2106 2939799 SGTC_2293 7624732 200 µM 0.124139402300057 0.458920678156981 no 1521 0.450602450454466 2158 894453 SGTC_1955 wogonin 32.4 µM 0.122902300513743 0.459357621864766 no 1522 0.451092231946712 2154 5281703 A flavanone. SGTC_2940 9060638 45.86 µM 0.122482602031375 0.459505870331026 no 1523 0.451258411906309 2064 4027022 SGTC_1234 0326-0494 15.5 µM 0.122253525032076 0.459586788687226 no 1524 0.451349118738503 2162 1547813 SGTC_556 4058-0063 51.5 µM 0.120717285572222 0.460129487624 no 1525 0.451957483609026 2089 6615692 SGTC_2253 7938677 135.83 µM 0.120368813980521 0.460252600655507 no 1526 0.452095497295742 2200 2301972 SGTC_736 0958-0254 92.6 µM 0.119198832761324 0.460665976173487 no 1527 0.452558915689428 2142 6812352 SGTC_2815 7968870 71.43 µM 0.118676205250869 0.460850643684684 no 1528 0.4527659443793 2127 2977326 YHR190W ERG9 SGTC_1466 k213-0079 57.5 µM 0.117490552839912 0.461269618582783 no 1529 0.453235664968411 2104 3657981 SGTC_2120 5538279 151.968 µM 0.116403967403907 0.461653623873507 no 1530 0.453666195618664 2121 2058197 SGTC_2765 myclobutanil 7.74 µM 0.113924470270628 0.462530025151996 no 1531 0.454648833690637 2099 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1735 st034310 56.75 µM 0.11261652909747 0.462992402668401 no 1532 0.455167290046215 2132 871153 SGTC_3228 9131799 49.47 µM 0.112602223849062 0.462997460073446 no 1533 0.455172960944441 2119 17015818 SGTC_405 ebelactone b 50 µM 0.112218544409745 0.463133106387302 no 1534 0.455325062864678 2076 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1957 st077035 62.4 µM 0.111161033743837 0.463507001636159 no 1535 0.455744325321795 2235 705593 SGTC_2278 7948257 134.34 µM 0.110774362070561 0.463643721988958 no 1536 0.45589763815404 2235 1247028 SGTC_1459 k035-0031 35.7 µM 0.110737637364295 0.463656707427447 no 1537 0.455912199605774 2127 3877128 YMR208W ERG12 SGTC_398 bronopol 33.3 µM 0.109738311626716 0.464010072459147 no 1538 0.456308457801947 2112 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_460 trequinsin 123 µM 0.10931070453803 0.464161284492285 no 1539 0.456478028240502 2228 5537 A vasodilator. SGTC_2665 lovastatin 100 µM 0.108684481839808 0.464382741063118 no 1540 0.456726375316752 2129 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1912 st060209 90.8 µM 0.106232832978698 0.465249844464887 no 1541 0.457698810690376 2101 688787 SGTC_2372 9071633 200 µM 0.105105889001691 0.465648479568345 no 1542 0.458145893221297 2248 21321366 SGTC_2962 9082311 13.18 µM 0.104358233270567 0.4659129676792 no 1543 0.458442533333601 2129 16459453 SGTC_1298 1079-1278 263 µM 0.103542199316407 0.466201662215204 no 1544 0.458766329622537 2150 2840950 SGTC_133 0724-0033 378.92 µM 0.102177901273647 0.466684359953963 no 1545 0.459307734083077 2233 280309 SGTC_423 5-fluorouracil 457 µM 0.101899066385962 0.466783019649751 no 1546 0.459418395511292 2115 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1947 st076332 61.6 µM 0.101441858143547 0.466944797314436 no 1547 0.459599854918422 2229 24208416 SGTC_2448 5185112 27.17 µM 0.101426369699132 0.466950277810906 no 1548 0.459606002207912 2120 5718189 SGTC_2998 9066762 71.4286 µM 0.1013279253164 0.466985111932762 no 1549 0.459645074538144 2187 4945196 SGTC_1647 st011722 22.4 µM 0.101264343248564 0.467007610308697 no 1550 0.459670310309633 2196 2854783 SGTC_2696 st077691 74.316 µM 0.10111262297391 0.467061296622487 no 1551 0.459730528859272 2162 757133 SGTC_2777 climbazole 1.536 µM 0.100987800724487 0.467105465502617 no 1552 0.459780072138439 2245 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2755 lomerizine 42.69 µM 0.100886225470835 0.46714140863406 no 1553 0.459820388898509 2155 3949 A calcium channel blocker. SGTC_1175 0741-0056 27.6 µM 0.100865659081662 0.467148686230884 no 1554 0.459828552060874 2211 765927 SGTC_877 0771-0151 33.1 µM 0.0997320720330944 0.467549832846978 no 1555 0.460278518835485 2137 6166523 SGTC_1516 st013856 110 µM 0.0991420223415739 0.467758648968338 no 1556 0.46051275370914 2156 5281404 A mutagen and neurotoxin. SGTC_845 0330-0138 4.51 µM 0.09789426997926 0.46820025246612 no 1557 0.461008125013701 2234 9039800 SGTC_558 k064-0027 21.3 µM 0.0973041180218551 0.468409132230089 no 1558 0.461242442906524 2187 5088526 SGTC_3022 9087993 49.47 µM 0.0962835489797555 0.468770375315438 no 1559 0.461647688195608 2243 17173644 SGTC_2824 7998404 51.95 µM 0.0947602066523108 0.469309628992071 no 1560 0.462252647539654 2181 837851 SGTC_513 4245-1575 41.7 µM 0.0944900350550618 0.469405273957823 no 1561 0.46235994895172 2198 719745 SGTC_1681 tripelennamine 100 µM 0.0943626984679631 0.469450353711251 no 1562 0.462410522929429 2261 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1200 1643-0193 18.4 µM 0.0940038882913347 0.469577381949141 no 1563 0.462553034003269 2248 5403974 SGTC_2314 7727897 200 µM 0.0937682591917317 0.469660802531788 no 1564 0.462646623028422 2168 900724 SGTC_2766 oltipraz 83.91 µM 0.0934359793120441 0.469778442985671 no 1565 0.462778604085956 2226 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3271 9137798 49.47 µM 0.0914998159406649 0.470463974905808 no 1566 0.463547726241081 2239 6498326 SGTC_80 0159-0065 512.242 µM 0.0909295394570013 0.470665907877641 no 1567 0.463774289160648 2244 1548079 SGTC_3071 9117417 49.47 µM 0.09071516301329 0.470741819804001 no 1568 0.463859460984022 2243 45595590 YGL055W OLE1 SGTC_2356 9061756 188.97 µM 0.0880596271863279 0.471682247537863 no 1569 0.464914642256592 2240 20104043 SGTC_231 b-estradiol 524 µM 0.0864440981217582 0.472254446326625 no 1570 0.46555669643571 2198 450 A steroid. SGTC_1241 0364-0022 50.8 µM 0.0862026116879965 0.472339982540489 no 1571 0.465652677305654 2199 4563895 SGTC_800 3448-7362 155 µM 0.0861480825820305 0.472359297314676 no 1572 0.465674350646763 2265 15991913 SGTC_2893 9048488 25.97 µM 0.0847923834136861 0.472839520783904 no 1573 0.466213224444522 2162 6467338 SGTC_982 1491-0518 27.5 µM 0.0833659261790472 0.473344851189998 no 1574 0.466780290570631 2180 3091256 SGTC_2653 dihydrofissinolide 100 µM 0.0832683748392082 0.473379410870866 no 1575 0.466819073081511 2206 6857746 SGTC_1607 st000305 50.6 µM 0.0828479289279855 0.473528365256185 no 1576 0.466986229159159 2244 5457690 SGTC_608 k048-0125 159 µM 0.0817444627145409 0.473919315688576 no 1577 0.467424960257031 2253 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1236 0330-0013 258 µM 0.081464885253541 0.474018372048776 no 1578 0.467536124769418 2178 4617066 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0812325859645689 0.474100678625429 no 1579 0.467628492643503 2217 688667 SGTC_269 exalamide 29 µM 0.0805300206368427 0.474349613121887 no 1580 0.467907860373833 2146 3316 A derivative of salicylamide. SGTC_601 0986-0029 62.9 µM 0.0797815748467207 0.474614815100265 no 1581 0.468205489373759 2213 24747981 SGTC_2145 5634607 200 µM 0.079547283226787 0.474697835589292 no 1582 0.468298662080472 2207 308662 SGTC_791 1348-1292 225 µM 0.0794298366423298 0.474739452825937 no 1583 0.46834536869907 2235 5437054 SGTC_849 0386-0493 241 µM 0.0791775910288575 0.474828837074923 no 1584 0.468445684196532 2151 726119 SGTC_3243 9134147 49.47 µM 0.0780786196552083 0.475218276732659 no 1585 0.468882757154809 2284 24282180 SGTC_2130 NSC 7 2.4545 µM 0.077919673168842 0.475274604158696 no 1586 0.468945975031119 2254 21448 SGTC_196 k015-0023 18.111 µM 0.0771478428133065 0.475548132260978 no 1587 0.469252966659921 2183 5211998 SGTC_2612 dictamnine 15.46 µM 0.0760962436142161 0.475920825854714 no 1588 0.469671264319553 2190 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_43 0570-0105 72.5 µM 0.0757255217064946 0.476052217148526 no 1589 0.469818735450865 2256 1114046 YDL195W SEC31 SGTC_1980 st071811 45.7 µM 0.075722161765519 0.476053407991055 no 1590 0.469820072035825 2244 4974850 SGTC_60 0986-0278 202 µM 0.073443100881461 0.47686120978164 no 1591 0.470726760318271 2095 3110598 SGTC_2656 pseudo-anisatin 100 µM 0.0731125271464508 0.476978387972608 no 1592 0.470858286558747 2235 6708809 A neurotoxin. SGTC_931 2812-0076 566 µM 0.071268576356872 0.477632047878997 no 1593 0.471592002024748 2283 3450959 SGTC_917 harmaline 728.087 nM 0.0710546282336883 0.477707894022774 no 1594 0.471677139137554 2239 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1386 3228-0095 33.8 µM 0.0708021178846962 0.477797411790747 no 1595 0.471777623114466 2255 870181 SGTC_1993 st073995 70.8 µM 0.0702973285385933 0.477976368663449 no 1596 0.471978504383124 2198 3098394 SGTC_1744 st037937 38.9 µM 0.0702524291678777 0.477992286510885 no 1597 0.471996372464661 2235 1016152 SGTC_5 0352-0601 109.883 µM 0.0695489387689279 0.47824169441515 no 1598 0.472276339711956 2203 762456 SGTC_1094 duloxetine 25.4 µM 0.0683835035872457 0.47865489394868 no 1599 0.472740176659074 2286 60834 A selective serotonin reuptake inhibitor. SGTC_1519 esterone 74 µM 0.0679023242925264 0.478825500509749 no 1600 0.472931694253937 2198 698 A steroid. SGTC_1833 st055984 71 µM 0.0674673932267119 0.478979712673542 no 1601 0.473104809647687 2169 676288 SGTC_386 1509-0011 3.07 µM 0.0665343497295825 0.479310549609367 no 1602 0.473476205578596 2273 3107280 SGTC_3066 9117245 49.47 µM 0.0664953886495309 0.4793243646728 no 1603 0.473491714455342 2253 17176980 SGTC_890 0929-0006 47.2 µM 0.0662857737919496 0.479398691645843 no 1604 0.473575154591765 2220 1378169 SGTC_2663 amphotericin b 100 µM 0.0661785371790544 0.479436716769748 no 1605 0.473617842079314 2263 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2809 7964133 12.99 µM 0.066069478759477 0.479475388081613 no 1606 0.473661255080909 2226 1253665 SGTC_19 0279-0214 38.434 µM 0.0655910723911395 0.479645029731925 no 1607 0.473851698504036 2284 3566274 YBR002C RER2 SGTC_1417 3966-0327 90.4 µM 0.0651037686759863 0.479817830148559 no 1608 0.474045689915646 2235 651118 SGTC_1491 4138-0063 26.5 µM 0.0619337528117365 0.480942025303813 no 1609 0.475307794112619 2306 23883227 SGTC_1737 st035557 69.7 µM 0.0615853317153926 0.481065596651083 no 1610 0.475446529181678 2308 5716916 SGTC_860 0443-0016 25.1 µM 0.0603009604633783 0.481521128566597 no 1611 0.475957968500374 2310 5337942 SGTC_1492 4158-0558 28.5 µM 0.0582572986438189 0.48224600991154 no 1612 0.476771840229863 2290 3967268 SGTC_1002 4049-0206 172 µM 0.0575910673104135 0.482482333174611 no 1613 0.477037182559047 2279 4662749 SGTC_2146 5545642 200 µM 0.0556847991719555 0.483158551700637 no 1614 0.477796454607813 2298 825326 SGTC_604 1000-0114 314 µM 0.0554186911979761 0.483252953201112 no 1615 0.47790245264844 2315 1572745 SGTC_580 1123-0028 41 µM 0.0551154029680393 0.483360545499474 no 1616 0.478023262501471 2297 1677248 YPR107C YTH1 SGTC_1781 st038725 66.3 µM 0.0547255921062034 0.48349883370779 no 1617 0.478178540178955 2245 4270275 YIL048W NEO1 SGTC_2064 5220758 200 µM 0.0539365000097509 0.483778775866184 no 1618 0.478492878087524 2249 788518 SGTC_2892 9047358 58.44 µM 0.0529881745234088 0.484115219005417 no 1619 0.478870664920275 2274 6466771 SGTC_2406 ethylparaben 405.7 µM 0.0528761611317096 0.484154959421905 no 1620 0.478915289239833 2153 8434 A possible steroid mimic. SGTC_3119 9125183 49.47 µM 0.0519242243330101 0.484492696467484 no 1621 0.479294536041054 2313 22695334 SGTC_3256 9138902 49.47 µM 0.0510250819955703 0.484811712821383 no 1622 0.479652767017446 2319 17228773 SGTC_44 0929-0055 61.211 µM 0.0504787669702504 0.485005550549884 no 1623 0.479870434666592 2271 1379590 SGTC_2531 methyl deoxycholate 70.07 µM 0.0501183797001846 0.485133421298045 no 1624 0.480014026630239 2276 16667744 Haematoxylin. SGTC_1121 fusaric acid 630.51 nM 0.0499489588284874 0.485193534865002 no 1625 0.480081531231727 2228 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1131 3454-3128 32.3 µM 0.0494068113594733 0.485385900774912 no 1626 0.480297550056568 2240 710982 SGTC_3027 9089541 49.47 µM 0.0480255061594217 0.485876033670158 no 1627 0.480847957540467 2266 9943819 SGTC_2018 5133068 143 µM 0.0479959782465892 0.485886511388485 no 1628 0.480859723904611 2319 785362 SGTC_2603 homopterocarpin 100 µM 0.0474303713674501 0.486087213852075 no 1629 0.481085111700754 2280 101795 A weak amylase inhibitor. SGTC_2583 asiatic acid 100 µM 0.0463793093122251 0.486460186712867 no 1630 0.481503963770447 2303 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_392 N-ethylmaleimide 8.33 µM 0.0461434858812226 0.486543871078888 no 1631 0.481597943090377 2294 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1265 0819-1001 68.8 µM 0.0452610768282072 0.486857008219202 no 1632 0.481949605908192 2333 3106768 SGTC_1210 3013-0140 750 nM 0.044461187579047 0.487140868878321 no 1633 0.482268394594888 2341 905973 SGTC_3074 9116018 49.47 µM 0.0438341884156756 0.48736337973865 no 1634 0.482518287425291 2310 17027303 SGTC_817 1391-0715 46 µM 0.0431309903814953 0.487612936900671 no 1635 0.48279855776302 2297 1353946 SGTC_1811 st050069 61.5 µM 0.0427050854901466 0.487764088174842 no 1636 0.482968312817473 2340 3877702 SGTC_2463 5473429 200 µM 0.0425771391996162 0.487809495945143 no 1637 0.483019309618435 2231 5399405 SGTC_367 0335-0881 7.1 µM 0.0421847198567204 0.487948765423705 no 1638 0.483175721752572 2295 23828853 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0394822022007656 0.488907926938198 no 1639 0.484252971519245 2333 77254 SGTC_2408 sulbentine 18.36 µM 0.0393325098452938 0.488961056786098 no 1640 0.484312643777138 2208 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_380 3970-0968 6 µM 0.0373708986344363 0.489657303178742 no 1641 0.485094637990697 2326 2891601 SGTC_2214 7179297 48.276 µM 0.0372336789411011 0.48970600858882 no 1642 0.48514934265509 2350 769744 SGTC_2767 sibutramine 71.45 µM 0.0368160560202537 0.489854242594526 no 1643 0.48531583593726 2336 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_292 k038-0015 474 µM 0.0367081464480723 0.489892545002825 no 1644 0.485358856548072 2319 46368540 SGTC_1634 st006576 41 µM 0.0362685154327991 0.490048592607001 no 1645 0.485534127230041 2336 3915356 SGTC_3333 9141820 12.094 µM 0.0345366601247408 0.490663331506533 no 1646 0.486224604611545 2297 1939433 SGTC_1695 st026914 34.495 µM 0.0342512294443418 0.490764650072777 no 1647 0.486338407646507 2332 3289191 SGTC_2416 tofa 880 nM 0.0328708307646997 0.491254654796703 no 1648 0.486888796949156 2264 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1220 1838-0075 193 µM 0.0319442076242839 0.491583588752523 no 1649 0.487258272013609 2307 5529645 SGTC_119 0121-0043 24.815 µM 0.031542926911968 0.491726037720349 no 1650 0.487418279218722 2348 1092378 SGTC_175 3793-3120 23.7 µM 0.0288351443874234 0.492687288829016 no 1651 0.488498035678979 2334 5322297 SGTC_821 1114-0266 29.2 µM 0.0283011718849538 0.492876851951831 no 1652 0.48871097297324 2337 3123235 SGTC_2294 7971431 200 µM 0.0273815167589451 0.493203338236326 no 1653 0.489077720105656 2331 5741572 SGTC_3311 9131146 2.8755 µM 0.0244580068910673 0.494241241129906 no 1654 0.490243639666033 2261 4900406 YPR165W RHO1 SGTC_1306 1185-0270 9.02 µM 0.0229859012085361 0.49476388249168 no 1655 0.49083075959245 2358 1548076 SGTC_913 3487-1245 167 µM 0.0229202958762073 0.494787174554462 no 1656 0.490856925439754 2350 4016153 SGTC_1243 0416-0003 5.65 µM 0.0225083437962324 0.494933431570554 no 1657 0.491021228150129 2343 2141977 SGTC_1936 st074407 74.3 µM 0.0215724109930189 0.495265722086228 no 1658 0.491394520623633 2354 809813 SGTC_2870 9038528 12.99 µM 0.0215268068898564 0.495281913303379 no 1659 0.491412709804655 2286 6463316 SGTC_644 1498-1197 63.3 µM 0.021374749448714 0.495335899621113 no 1660 0.491473357992109 2337 6741615 SGTC_991 3996-0057 64.7 µM 0.0213280996434239 0.49535246213724 no 1661 0.491491964330167 2355 715343 SGTC_787 4152-0075 138 µM 0.0211396429692342 0.495419371751909 no 1662 0.491567130718095 2320 9566539 SGTC_882 0843-0131 351 µM 0.0206456152648022 0.495594771842371 no 1663 0.491764176245007 2378 5425421 SGTC_561 1550-0330 72.9 µM 0.0204503952215027 0.495664083198502 no 1664 0.491842041334283 2349 6812934 SGTC_934 2950-0684 338 µM 0.0203630819278323 0.495695083145969 no 1665 0.491876867046681 2377 1121253 SGTC_2050 5263056 171 µM 0.0199891360487971 0.495827850192005 no 1666 0.492026019506305 2365 763468 YGL055W OLE1 SGTC_158 k038-0087 26.446 µM 0.019744988158035 0.495914533558923 no 1667 0.492123401202177 2323 X158 SGTC_1323 1348-1351 11.2 µM 0.0188992376552263 0.496214814092672 no 1668 0.492460743848053 2320 6989654 SGTC_330 1488-0319 80.1 µM 0.0182567070392586 0.496442943612911 no 1669 0.492717032241168 2331 6846614 SGTC_2969 9091408 28.7 µM 0.0180796730842801 0.496505799457565 no 1670 0.492787646915465 2314 4286311 SGTC_199 4063-0024 41.6 µM 0.0168278554197675 0.496950259272771 no 1671 0.493286973814855 2359 306215 SGTC_2589 lobaric acid 100 µM 0.0152691881540746 0.497503671745861 no 1672 0.493908711954234 2371 73157 A novel microtubule depolymerizer. SGTC_1794 st048918 76.9 µM 0.0137447917653485 0.498044920829834 no 1673 0.494516794077271 2372 672303 SGTC_2864 9034755 47.6 µM 0.0124593438776539 0.498501332181852 no 1674 0.495029569539145 2383 4930451 SGTC_639 0833-0042 114 µM 0.0119157502680272 0.498694341248766 no 1675 0.495246415905334 2370 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1608 st001473 40.5 µM 0.0109361600255344 0.499042156598631 no 1676 0.495637190345797 2383 7292267 SGTC_3270 9137563 49.47 µM 0.0107285242134759 0.499115880304553 no 1677 0.495720020190249 2375 17015724 SGTC_2165 5727197 32.143 µM 0.00825544691549735 0.499993979113566 no 1678 0.496706590590802 2367 1361712 SGTC_657 3534-0529 86.7 µM 0.00822153249691831 0.499993979113566 no 1679 0.49672012002714 2383 1049549 SGTC_2425 5628681 7.85 µM 0.00788351203846373 0.499873960381569 no 1680 0.496854966307019 2384 5714958 SGTC_2519 cryptotanshinone 88.04 µM 0.00715514877238014 0.499615345213369 no 1681 0.497145532988445 2395 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_776 4476-4378 112 µM 0.00643844545853368 0.499360870225159 no 1682 0.497431449632479 2337 2892008 SGTC_3016 9080866 49.47 µM 0.00582361617877838 0.499142567163108 no 1683 0.497676726413575 2396 17066299 SGTC_1487 3970-0795 2.82 µM 0.00469540488900311 0.49874198191511 no 1684 0.498126811349153 2396 3765103 SGTC_822 1487-0950 154 µM 0.00325251147611168 0.498229666825085 no 1685 0.49870243794247 2399 1958375 SGTC_2376 9072922 81.32 µM 0.00309540766333732 0.498173885558901 no 1686 0.498765112980038 2391 17087968 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.00292015526318147 0.498111660499026 no 1687 0.498835028255859 2401 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_76 0433-0009 400.328 µM 0.00273539934929845 0.49804606117445 no 1688 0.498908734906665 2369 2841569 SGTC_83 0170-0301 39.027 µM 0.00255598664986392 0.497982359058955 no 1689 0.498980309967512 2397 3089716 SGTC_1167 k781-0610 148 µM 0.00207118133070746 0.49781022477004 no 1690 0.499173718787565 2396 4525169 SGTC_3281 9140613 49.47 µM 0.00201876190910685 0.497791612828417 no 1691 0.499194631067427 2398 16013766 SGTC_2085 5307070 144.047 µM 0.00148076822293793 0.497600594083216 no 1692 0.499409259164279 2401 2840351 SGTC_1335 1486-0900 202 µM -0.0014261612399563 0.496568477323003 no 1693 0.499431044175582 2407 X1335 SGTC_1011 4112-3381 17.4 µM -0.00505576642131706 0.495279804748591 no 1694 0.497983049607175 2460 2877139 SGTC_1413 3910-0535 34.4 µM -0.00518210306007646 0.495234950386614 no 1695 0.497932649240781 2420 2876951 SGTC_3106 9121286 49.47 µM -0.00539886254122504 0.49515799258123 no 1696 0.497846175929411 2453 15943471 SGTC_1935 st074532 41.6 µM -0.00599153076165756 0.49494757389925 no 1697 0.497609739355963 2439 2829742 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.00600598068941538 0.494942443668902 no 1698 0.497603974772552 2412 97141 SGTC_265 mycophenolic acid 32.932 µM -0.00632682544892909 0.49482853276126 no 1699 0.497475978666604 2423 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1245 0418-0076 17.2 µM -0.00644755925264091 0.494785668223558 no 1700 0.497427813830141 2429 6790114 SGTC_2261 9010538 184.68 µM -0.0065866318877228 0.494736292862108 no 1701 0.497372333054222 2431 6457250 SGTC_3273 9137859 49.47 µM -0.00751964193541218 0.494405045718145 no 1702 0.497000125169839 2416 2377234 SGTC_522 1273-0010 11.6 µM -0.0082009491176324 0.494163163224858 no 1703 0.496728331330585 2492 5705015 SGTC_53 0973-0023 39.979 µM -0.00821947927865132 0.494156584545642 no 1704 0.496720939115042 2424 674768 SGTC_2258 7960471 200 µM -0.0091725965471894 0.493818205818445 no 1705 0.496340714729593 2434 2974708 SGTC_1449 4112-4002 201 µM -0.0095041490105424 0.493700498037671 no 1706 0.4962084502016 2432 2059539 SGTC_1812 st052057 4.327 µM -0.010528358666834 0.493336886556821 no 1707 0.495799870179546 2419 3645418 SGTC_2816 7982706 58.44 µM -0.0107723241960457 0.493250275537074 no 1708 0.495702547535024 2445 2981853 SGTC_365 0121-0052 13.6 µM -0.0107925210402265 0.493243105401972 no 1709 0.495694490628314 2435 3101739 SGTC_141 0443-0274 32.331 µM -0.0115993189143556 0.492956683763561 no 1710 0.495372645025398 2424 1627241 SGTC_1182 1222-0449 220 µM -0.0122839068131458 0.492713650779721 no 1711 0.495099553445665 2436 658318 SGTC_993 3909-8757 62.7 µM -0.0144357635581559 0.49194974621438 no 1712 0.494241163582673 2439 4288324 YLR208W SEC13 SGTC_2823 7987624 58.44 µM -0.0151413781286827 0.49169926083457 no 1713 0.493959694883204 2442 2239440 SGTC_2732 terfenadine 20 µM -0.0158286229455065 0.491455299660179 no 1714 0.493685556743291 2427 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_784 4579-0127 173 µM -0.0167303846697946 0.491135193197573 no 1715 0.493325853544643 2460 1948547 SGTC_809 3998-0021 90 µM -0.0168937485999431 0.491077203040087 no 1716 0.493260689975635 2439 715485 SGTC_61 0978-8327 98.565 µM -0.0171073538908809 0.491001378725998 no 1717 0.493175486107572 2431 6150059 YHR072W ERG7 SGTC_2045 5106652 78.05 µM -0.0179927240308595 0.490687098887071 no 1718 0.492822328927539 2439 673349 SGTC_3223 9129970 49.47 µM -0.0181348517409119 0.490636648347247 no 1719 0.492765637424815 2451 17248386 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0191632953690833 0.490271590086009 no 1720 0.492355419137294 2471 5282362 SGTC_1325 1431-0015 227 µM -0.0197923692744575 0.490048296840928 no 1721 0.492104502564706 2435 1103340 SGTC_1262 0737-0114 49.6 µM -0.0223820505908589 0.489129108817209 no 1722 0.491071599159722 2442 765919 SGTC_2335 9018011 154.17 µM -0.0226716758349517 0.489026312001721 no 1723 0.490956084717958 2481 6458208 SGTC_872 0588-0139 234 µM -0.0230981298788624 0.488874951808888 no 1724 0.490785998714931 2453 2047100 SGTC_1643 st009866 20.2 µM -0.0253683876194466 0.488069202800327 no 1725 0.489880563007162 2452 3156273 YOR207C RET1 SGTC_440 fluspirilene 35.1 µM -0.0257151639601053 0.487946130807023 no 1726 0.489742264382869 2630 3396 An atypical antipsychotic. SGTC_757 1066-0008 322 µM -0.0263489330163945 0.487721207187644 no 1727 0.489489512769828 2567 6842497 SGTC_2991 9074669 71.4286 µM -0.0264340168153353 0.487691011379939 no 1728 0.489455581064007 2468 17333109 SGTC_742 0kpi-0133 140 µM -0.0274449216497298 0.487332251840964 no 1729 0.489052434716517 2470 2728852 SGTC_1193 1488-0126 41.5 µM -0.0279193653140113 0.487163880269953 no 1730 0.48886323158811 2474 1384710 SGTC_2044 5102272 200 µM -0.0281229556333584 0.487091630406631 no 1731 0.488782042682413 2485 592666 SGTC_1456 k015-0012 13 µM -0.0284026696110942 0.486992366571462 no 1732 0.488670497509929 2452 2989616 SGTC_3244 9134489 49.47 µM -0.0290812466197822 0.48675155909822 no 1733 0.488399896250803 2490 16584271 SGTC_1016 4226-1401 38 µM -0.0306864881560642 0.486181924411601 no 1734 0.487759783489163 2459 2901613 SGTC_1835 st008666 49.2 µM -0.0308340711547811 0.486129554628022 no 1735 0.487700934239174 2469 690455 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0317165066915152 0.485816427660455 no 1736 0.487349065536419 2433 368090 SGTC_168 3970-0862 530.542 µM -0.0318019082786055 0.485786123879567 no 1737 0.487315012410653 2497 3135186 SGTC_2983 9022671 12.99 µM -0.0319693601613389 0.48572670572383 no 1738 0.487248242725562 2493 6405161 SGTC_2435 5706476 10.6 µM -0.0324089219690501 0.485570734357715 no 1739 0.487072973762214 2479 5725375 SGTC_1157 4092-0394 27.6 µM -0.032680955879669 0.485474208648412 no 1740 0.486964505392499 2552 3659885 SGTC_1868 st057644 42.7 µM -0.0347456506162097 0.484741621795435 no 1741 0.486141279478931 2471 688665 SGTC_2645 abamectin 100 µM -0.0348473511684208 0.484705538116719 no 1742 0.486100731383908 2472 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_8 0354-0001 70 µM -0.0356879555528449 0.484407293836326 no 1743 0.485765587255925 2461 4993152 SGTC_397 arbidol 50 µM -0.0359276601368703 0.484322248855612 no 1744 0.485670020250388 2573 131410 A RNA synthesis inhibitor. SGTC_2837 9008476 45.46 µM -0.0360149136253742 0.484291292297622 no 1745 0.485635233657773 2532 2992805 SGTC_2524 avocatin b 10.57 µM -0.0362598293730671 0.484204399446877 no 1746 0.485537590188718 2480 6710748 SGTC_1416 3966-0321 25.3 µM -0.0367407273793085 0.484033785414879 no 1747 0.485345867399152 2485 582530 YLR208W SEC13 SGTC_3186 9110464 49.47 µM -0.0369896970361876 0.483945456569466 no 1748 0.485246610347007 2500 17018021 SGTC_3328 9140624 29.0385 µM -0.0381122798840822 0.483547199222461 no 1749 0.484799080246357 2485 4904392 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.04050059877124 0.482699953350917 no 1750 0.483847014842141 2514 688788 SGTC_451 chloral hydrate 100 µM -0.0417986181146313 0.482239519082922 no 1751 0.483329618318315 2538 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2022 5136654 200 µM -0.0440550674398833 0.481439166646563 no 1752 0.482430254486449 2542 1713771 SGTC_14 0354-0009 295 µM -0.044481215608195 0.481288022106112 no 1753 0.482260412464253 2484 1713507 SGTC_1379 2144-0755 36.5 µM -0.0454903419345272 0.480930119952693 no 1754 0.48185823647527 2490 5392327 SGTC_1212 0520-0165 585 µM -0.0455492907572795 0.480909213319538 no 1755 0.481834743649309 2548 5403258 SGTC_6 0844-0013 19.835 µM -0.0458101614697282 0.480816694235591 no 1756 0.481730779816701 2501 1584900 SGTC_2673 kobusone 100 µM -0.0469394046647664 0.480416214551926 no 1757 0.48128076115518 2503 6710676 An epoxy ketone and protein crosslinker. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0483976670353688 0.479899079388148 no 1758 0.480699659282038 2652 6710655 SGTC_2894 9048625 32.47 µM -0.0514024090954306 0.478833632701067 no 1759 0.47950243256618 2508 4092861 SGTC_3298 9116858 71.43 µM -0.0531130261620115 0.478227134797378 no 1760 0.478820926363416 2571 2506942 SGTC_2551 apiole 73.87 µM -0.0532811016651944 0.478167546460548 no 1761 0.478753968748637 2498 10659 A possible DNA adduct former. SGTC_364 0083-0097 67.7 µM -0.0535530837597778 0.478071120827512 no 1762 0.47864561828509 2568 5207356 SGTC_1660 st012960 28.1 µM -0.0555783163620871 0.47735315719228 no 1763 0.477838869417811 2543 24207266 SGTC_2176 5809774 33.9695 µM -0.0574775011983991 0.47667994538848 no 1764 0.47708241395839 2536 2870539 SGTC_2666 tannic acid 100 µM -0.0576014191465674 0.476636021979502 no 1765 0.477033059618172 2517 16134267 A thiamine antagonist. SGTC_2863 9028737 58.44 µM -0.057620627271629 0.476629213577667 no 1766 0.477025409391165 2597 6460917 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0589986598432643 0.476140781980509 no 1767 0.476476587772164 2509 1241132 A phosphatase inhibitor. SGTC_2513 baicalein 25.65 µM -0.0593589255113493 0.476013094845276 no 1768 0.476333114017686 2544 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3029 9088683 49.47 µM -0.0594488595208264 0.475981220373678 no 1769 0.476297298787448 2605 25236615 SGTC_523 1934-0222 13.7 µM -0.059540835874257 0.475948622212148 no 1770 0.476260670414249 2520 1361595 SGTC_1281 0884-0031 11.8 µM -0.0601910808753592 0.475718167673622 no 1771 0.476001724633409 2522 1548255 SGTC_2243 6634756 200 µM -0.062017699892564 0.475070835939954 no 1772 0.475274368328514 2662 885676 SGTC_20 0481-0013 4.944 µM -0.0623754899419604 0.474944047117879 no 1773 0.475131906568425 2504 182045 SGTC_2177 5811945 192 µM -0.0635740832862749 0.474519324301903 no 1774 0.47465468426348 2580 5343475 SGTC_1181 1222-0449 220 µM -0.0638577326916911 0.474418817055181 no 1775 0.474541753988514 2580 658318 SGTC_2000 st075254 36.4 µM -0.0646548093111671 0.474136392707115 no 1776 0.4742244222199 2519 17234175 SGTC_3123 9126162 49.47 µM -0.0664054920117958 0.473516127498728 no 1777 0.47352749893165 2530 25239884 SGTC_1727 st034309 9.9045 µM -0.0670192201466043 0.473298699328627 no 1778 0.473283201067656 2768 870305 SGTC_909 3448-9333 149 µM -0.0681164765690881 0.472909989328483 no 1779 0.472846457207189 2527 3344074 SGTC_1101 ebselen 5.29 µM -0.0690768137600397 0.472569804984367 no 1780 0.472464238436792 2518 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_816 0325-0417 81.3 µM -0.0710565829160336 0.471868566314944 no 1781 0.471676361298218 2574 68101 SGTC_2097 5376186 200 µM -0.0711964147620078 0.471819040833327 no 1782 0.471620717391594 2547 742755 SGTC_2951 9072950 58.06 µM -0.0719373237852839 0.471556633821122 no 1783 0.471325893447707 2526 16488155 SGTC_24 0417-1663 219 µM -0.0736371402006117 0.470954658374267 no 1784 0.470649558870904 2580 4329390 SGTC_3017 9080681 49.47 µM -0.0739701547636068 0.470836731845466 no 1785 0.470517066615392 2607 16451914 SGTC_1408 3909-7976 48.8 µM -0.074337483833997 0.470706656890456 no 1786 0.470370925870624 2562 24152374 SGTC_2138 5575593 77.673 µM -0.0746699670104348 0.470588923914705 no 1787 0.470238651898065 2537 762213 SGTC_3291 9121177 71.43 µM -0.0757540549941908 0.470205064042559 no 1788 0.46980738491899 2581 17015612 SGTC_1398 3558-0053 112 µM -0.076159915800911 0.470061361705884 no 1789 0.469645936292734 2543 4532369 SGTC_2051 5263410 176 µM -0.0767136452536446 0.469865310101221 no 1790 0.46942567459416 2528 227584 SGTC_1928 4'-methoxychalcone 40.3 µM -0.0776221483731579 0.469543664361332 no 1791 0.469064311840355 2665 641818 SGTC_501 nsc-95397 161 µM -0.0790735303515767 0.469029859532691 no 1792 0.468487068646415 2683 262093 SGTC_2795 7780010 54.55 µM -0.0794058853310696 0.46891220952207 no 1793 0.468354893804033 2637 953673 SGTC_1817 st052116 64.4 µM -0.079429704237085 0.468903777995201 no 1794 0.468345421354753 2610 4361398 SGTC_2621 lithochol-11-enic acid 100 µM -0.0806852847029601 0.468459341632149 no 1795 0.467846119881787 2531 6708711 SGTC_306 1672-3436 11.6 µM -0.0809994829688807 0.468348131362847 no 1796 0.467721181843092 2618 6797378 SGTC_2310 7668677 200 µM -0.0844087093041505 0.467141598569116 no 1797 0.466365741488511 2636 2197143 SGTC_766 1391-0721 126 µM -0.0852963351420606 0.466827514884357 no 1798 0.466012902524785 2637 1020919 YIL115C NUP159 SGTC_3314 9135860 59.4275 µM -0.0867270050543198 0.466321320275799 no 1799 0.465444255179531 2572 25252478 SGTC_226 1,3-diallylurea 8.28947 mM -0.0869430187450508 0.466244895783044 no 1800 0.46535840247465 2653 74537 YKL182W FAS1 SGTC_2874 9043904 71.43 µM -0.0909273819473721 0.464835475444426 no 1801 0.463775146331587 2649 4463428 SGTC_2134 5324836 1.464 µM -0.0910760648495617 0.464782889091434 no 1802 0.463716075534569 2610 699272 SGTC_1679 SEC14.276 6.7 µM -0.0913867852359416 0.464672995107278 no 1803 0.463592630831799 2698 1005053 YMR079W SEC14 SGTC_2390 9097792 176.6 µM -0.0918188532131781 0.464520188013324 no 1804 0.463420982319738 2590 4497149 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0939708663347906 0.463759175804752 no 1805 0.462566149799766 2583 279621 SGTC_916 4466-0038 42 nM -0.0958786492354687 0.463084641030964 no 1806 0.461808475944075 2600 5722064 YGL116W CDC20 SGTC_2432 5630864 12.22 µM -0.0963022626206086 0.462934878382713 no 1807 0.461640257064962 2685 5714970 SGTC_3045 9092950 49.47 µM -0.0966628567458519 0.462807399459869 no 1808 0.461497068837843 2580 44120432 SGTC_495 decylubiquinone 155 µM -0.0967048921582665 0.46279253915247 no 1809 0.461480377331352 2628 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_22 0964-0034 14.468 µM -0.0975647017036222 0.4624885917604 no 1810 0.461138977349321 2610 138402 SGTC_1983 st071813 46.9 µM -0.0981244510127641 0.462290729067556 no 1811 0.460916736056869 2650 11838595 SGTC_2515 chrysin 20.77 µM -0.0987171285703067 0.462081236921572 no 1812 0.460681434331189 2683 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2711 st079103 59.1 µM -0.09983645537909 0.461685620216851 no 1813 0.460237082707442 2670 54693780 SGTC_1071 trifluoperazine 6.31 µM -0.100809795775009 0.461341631989842 no 1814 0.459850725277387 2714 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2868 9035608 32.47 µM -0.101327246778145 0.461158771389895 no 1815 0.45964534384964 2547 6462614 SGTC_2875 9039966 71.43 µM -0.101461726061202 0.461111249465377 no 1816 0.459591969451096 2685 6463691 SGTC_1093 fluphenazine 7.97 µM -0.10263108688007 0.460698047390623 no 1817 0.459127884673568 2609 6602611 An atypical antipsychotic. SGTC_3353 9151644 39.2805 µM -0.102960867526976 0.4605815246733 no 1818 0.458997014514053 2677 4909158 SGTC_542 3381-0244 89.3 µM -0.103496972008717 0.460392107956739 no 1819 0.458784276288748 2714 1112843 SGTC_34 0469-0683 81.75 µM -0.104424236412172 0.460064507652337 no 1820 0.458416344973459 2663 3690923 SGTC_2487 5918373 44.05 µM -0.104798178303504 0.459932402531018 no 1821 0.458267977797019 2573 2876279 SGTC_1621 st003705 32.4 µM -0.106087047380433 0.459477108537635 no 1822 0.457756643921119 2660 24207032 SGTC_3163 9099914 49.47 µM -0.106580536968425 0.459302796996705 no 1823 0.457560879935346 2602 16268368 SGTC_255 tunicamycin 200.472 nM -0.108769538962589 0.458529687395397 no 1824 0.456692642412489 2690 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2449 5812982 45.77 µM -0.109630689299742 0.45822558997985 no 1825 0.456351135404295 2595 776185 SGTC_2338 7999974 200 µM -0.111239224048039 0.45765763485373 no 1826 0.455713324169181 2705 315925 SGTC_1019 4262-0212 3.4 µM -0.112093027743848 0.457356201635991 no 1827 0.455374822820058 2597 4677213 SGTC_2683 piperine 63.03 µM -0.113293400442252 0.456932454641815 no 1828 0.454898974619572 2613 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3162 9099653 49.47 µM -0.11336639570583 0.456906687949846 no 1829 0.454870040133013 2610 25237511 SGTC_2689 tacrolimus 100 µM -0.113633775928186 0.456812306609354 no 1830 0.454764055720845 2706 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1982 st072467 71.9 µM -0.115925052197041 0.456003619751415 no 1831 0.453855970383605 2584 3163533 SGTC_3114 9122766 49.47 µM -0.116016892392188 0.455971209296297 no 1832 0.45381957700358 2664 17176985 SGTC_1742 st038235 28.8875 µM -0.116029541634834 0.455966745394595 no 1833 0.453814564537042 2726 564103 YBR002C RER2 SGTC_2872 9044037 25.97 µM -0.11696794085279 0.45563560103874 no 1834 0.453442729273517 2600 6465195 SGTC_1146 3579-1023 7 µM -0.117763712305633 0.455354811617458 no 1835 0.453127441402663 2731 X1146 SGTC_762 1165-0429 115 µM -0.11934750993343 0.454796032208081 no 1836 0.452500022482811 2665 5967793 SGTC_471 1-acyl-paf 4 µM -0.119861543656759 0.454614695215843 no 1837 0.452296414252574 2602 16759367 SGTC_1638 st008370 60.6 µM -0.121849197772973 0.453913594718293 no 1838 0.451509225009744 2599 24207134 SGTC_69 0096-0274 206.684 µM -0.123336453349647 0.453389092398019 no 1839 0.450920337793833 2921 6741392 SGTC_3188 9110789 49.47 µM -0.123740883468949 0.453246478252561 no 1840 0.450760220037416 2737 849217 SGTC_343 4130-2827 29.8 µM -0.124384565734317 0.453019509093684 no 1841 0.450505396601394 2655 1118244 SGTC_552 k242-0005 476 µM -0.125488238848631 0.452630378066068 no 1842 0.450068517738343 2734 4088318 SGTC_465 cgp-37157 41 µM -0.127033691163504 0.452085561875469 no 1843 0.449456866431459 2657 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3240 9133527 49.47 µM -0.127668449749112 0.451861817377555 no 1844 0.449205679590334 2631 17617455 SGTC_3301 9125354 19.7965 µM -0.127673432782917 0.451860060980574 no 1845 0.449203707783227 2630 41905162 SGTC_1948 st076329 66.6 µM -0.128113477656123 0.451704959694411 no 1846 0.44902958515739 2613 24208413 SGTC_332 4112-0506 40.9 µM -0.128375211549973 0.451612710634752 no 1847 0.448926023571001 2645 2790355 SGTC_1053 3366-3204 134 µM -0.128923265511483 0.451419555498611 no 1848 0.4487091835409 2677 3632071 YPR165W RHO1 SGTC_2667 digitoxin 100 µM -0.129760357289911 0.451124554617115 no 1849 0.448378013983533 2676 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.130719121424941 0.450786708153998 no 1850 0.447998752715158 2695 1273210 SGTC_2988 9073640 71.4286 µM -0.130749493631048 0.450776006267376 no 1851 0.447986739063341 2786 9102229 SGTC_1939 st074455 53.6 µM -0.131208862924389 0.450614148238048 no 1852 0.447805042487007 2831 1644229 SGTC_2877 9040724 71.43 µM -0.131355226437018 0.450562579014488 no 1853 0.447747152911919 2761 6463895 SGTC_1222 0366-0074 1.18 µM -0.133399086270465 0.449842539963721 no 1854 0.446938884000459 2737 286520 SGTC_2007 4011539 71.82 µM -0.134480818905886 0.449461518976253 no 1855 0.446511188801406 2645 45595301 SGTC_954 1189-0853 2.85 µM -0.136347672293741 0.448804063023607 no 1856 0.445773219351797 2607 2828194 SGTC_633 0437-0093 97.7 µM -0.136558343534184 0.448729879026339 no 1857 0.445689952496908 2631 2831118 SGTC_1048 3161-0300 24.5 µM -0.136762336446575 0.448658048387444 no 1858 0.445609327503698 2637 2165101 SGTC_3200 9114385 49.47 µM -0.13683226700447 0.448633424602247 no 1859 0.445581689067072 2777 17018030 YLR208W SEC13 SGTC_421 streptovitacin 30 mM -0.138972384705362 0.447879947478823 no 1860 0.444735985537129 2851 91467 include heat shock SGTC_2485 5633444 17.78 µM -0.139149707112751 0.447817525488805 no 1861 0.444665924833246 2736 5724239 SGTC_477 mead ethanolamide 10 µM -0.13980223405812 0.447587830574008 no 1862 0.444408124054783 2633 16061185 SGTC_1278 0874-0585 172 µM -0.139896009979772 0.447554822111835 no 1863 0.444371076931585 2705 766306 SGTC_3342 9147791 14.508 µM -0.140548555385482 0.447325140807167 no 1864 0.444113295766104 2652 1838168 SGTC_1091 telmisartan 47.6 µM -0.141841189267425 0.446870214981008 no 1865 0.443602724316783 2754 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3129 9127257 49.47 µM -0.142660696532094 0.44658183613633 no 1866 0.443279079381247 2685 837894 SGTC_1190 1486-1332 13 µM -0.145995423965175 0.4454086619202 no 1867 0.441962500434337 2646 4150046 SGTC_41 0478-0632 82.643 µM -0.146149568339681 0.445354444615595 no 1868 0.441901658300556 2662 3750424 SGTC_2404 5161160 200 µM -0.147317359540692 0.444943729903142 no 1869 0.441440765519161 2643 2831543 SGTC_1360 1598-0022 39.8 µM -0.147777554450955 0.444781894557807 no 1870 0.441259161890091 2759 761525 SGTC_503 tyrphostin 8 294 µM -0.1481897593854 0.444636943514721 no 1871 0.44109650670717 2706 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2122 5258151 111.688 µM -0.148534215188963 0.444515821995762 no 1872 0.440960592804997 2704 2173356 SGTC_1842 st055362 61.2 µM -0.148549422841491 0.444510474625072 no 1873 0.440954592394472 2679 676032 SGTC_150 3970-0969 77.2 µM -0.1486800742717 0.444464534905067 no 1874 0.440903042444854 2792 6615640 SGTC_2945 9067681 61.76 µM -0.148846285938496 0.444406092555566 no 1875 0.440837463262653 2618 16456930 SGTC_225 nsc-122657 1.016 µM -0.150133907265283 0.443953387912699 no 1876 0.44032948451201 2777 275685 SGTC_2719 novobiocin 32.65 µM -0.151487797139776 0.443477463305965 no 1877 0.43979546811084 2748 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2704 st078022 71.1 µM -0.151511802802866 0.443469025475906 no 1878 0.439786000513742 2808 54697681 SGTC_2075 5212009 200 µM -0.151979107560018 0.443304776089035 no 1879 0.43960170698599 2779 780898 SGTC_1641 st009299 47.1 µM -0.153088256036356 0.442914968994251 no 1880 0.439164338517931 2673 4046054 SGTC_483 fpl-64176 144 µM -0.153337032339393 0.442827544838473 no 1881 0.439066249195355 2679 3423 SGTC_2361 9034121 116 µM -0.153729290218364 0.442689704512258 no 1882 0.438911594521202 2718 6496917 SGTC_1484 3473-2379 286 µM -0.154765960970866 0.442325449446185 no 1883 0.438502913514959 2679 671917 SGTC_2081 5214970 32.255 µM -0.155287672102807 0.44214215419636 no 1884 0.438297266979772 2717 2063512 SGTC_973 1325-0077 65.9 µM -0.156329905332848 0.441776018572852 no 1885 0.437886492538238 2766 2835149 SGTC_2792 7535235 81.82 µM -0.156776533368107 0.441619133741104 no 1886 0.43771048389278 2762 1281891 SGTC_2628 lathosterol 100 µM -0.157428629377254 0.441390091639916 no 1887 0.437453525893823 2818 6710616 SGTC_2442 5158906 48.48 µM -0.158771590531255 0.440918452001344 no 1888 0.436924416162239 2829 1893835 SGTC_2298 7976326 193.81 µM -0.15923330140729 0.440756321322841 no 1889 0.436742533920373 2736 2235818 SGTC_2001 4023502 57.655 µM -0.161478919391437 0.439967910260257 no 1890 0.435858106675429 2797 108941 YCR052W RSC6 SGTC_2979 9012552 45.46 µM -0.162738986788089 0.439525618892451 no 1891 0.435361974569449 2781 17100905 SGTC_2198 6589944 200 µM -0.163365541506704 0.439305722412396 no 1892 0.435115316130555 2728 5290268 SGTC_372 0155-0182 15.9 µM -0.1635743737186 0.439232434538536 no 1893 0.435033109877767 2702 771486 SGTC_1145 3546-0597 10.2 µM -0.163700254000792 0.439188258939048 no 1894 0.434983558790921 2734 875334 SGTC_3128 9127691 49.47 µM -0.163904852249237 0.439116460189574 no 1895 0.434903023609962 2859 41316314 SGTC_1051 3253-3903 78 µM -0.165131393836354 0.438686077507685 no 1896 0.43442028174502 2672 5509239 SGTC_510 ag-490 170 µM -0.165447271919019 0.43857525037775 no 1897 0.434295974348049 2753 5328779 SGTC_2312 7706453 155.7 µM -0.166184537384158 0.438316596498423 no 1898 0.434005863811197 2733 976098 SGTC_615 k087-0205 167 µM -0.166745273440222 0.438119891834042 no 1899 0.433785240565045 2717 9642773 SGTC_1612 st002233 45.4 µM -0.166778532895615 0.438108224988488 no 1900 0.433772155182121 2689 1035021 SGTC_1135 dihydrocapsaicin 536.708 nM -0.167203013905902 0.437959329070619 no 1901 0.433605156525075 2679 107982 A Capsaicinoid. SGTC_1300 1094-0077 113 µM -0.168043366629823 0.437664583058361 no 1902 0.433274581253366 2711 5532636 SGTC_3143 9086658 49.47 µM -0.168631092013059 0.437458464311922 no 1903 0.433043411444239 2794 25236626 SGTC_1421 4029-0249 71.4 µM -0.169222430465317 0.437251095569334 no 1904 0.432810843629672 2847 2894095 SGTC_1629 st005085 44.9 µM -0.170744765213254 0.436717327360803 no 1905 0.432212231047215 2710 24207091 SGTC_191 3914-0123 66.505 µM -0.171129160298798 0.436582567115789 no 1906 0.43206110373173 2718 3144412 SGTC_229 benomyl 22.8748 µM -0.171148270373742 0.43657586774655 no 1907 0.43205359074628 2782 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1927 st060202 13.8 µM -0.171882179172262 0.436318597031722 no 1908 0.431765078516189 2668 688887 SGTC_1736 st036774 51 µM -0.172832859693476 0.435985377352695 no 1909 0.431391403701682 2996 1272247 SGTC_1139 k015-0024 46.9 µM -0.173760320660247 0.435660340058695 no 1910 0.431026914732834 2698 2766652 SGTC_493 zm226600 134 µM -0.17391434262273 0.435606365835917 no 1911 0.430966390310249 2882 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1294 1000-1494 117 µM -0.174177857083764 0.435514024721159 no 1912 0.430862843509815 2737 712797 YDL207W GLE1 SGTC_2745 rifampicin 24.3 µM -0.174886014588018 0.435265888588678 no 1913 0.430584599828618 2800 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1030 k029-0042 36.7 µM -0.175366285938581 0.435097617536897 no 1914 0.430395914984639 2765 6080581 SGTC_2709 st078560 56 µM -0.17621953898974 0.434798695153846 no 1915 0.430060735545693 2829 17250903 SGTC_3122 9126309 49.47 µM -0.17686904253971 0.434571177839351 no 1916 0.429805627845865 2710 17591206 SGTC_1539 benzyladenosine 56 µM -0.179558644003792 0.433629257549912 no 1917 0.428749537099122 2711 92208 A nucleotide analog. SGTC_272 doxorubicin 8.13 µM -0.179584366946279 0.433620250977057 no 1918 0.428739439256478 2700 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_775 4577-0580 57.3 µM -0.180605112226194 0.433262877405334 no 1919 0.42833877144919 2945 2006902 SGTC_215 1287-0124 461.5 µM -0.180893751471623 0.433161831677747 no 1920 0.428225486773169 2792 5560863 SGTC_3343 9148379 18.9835 µM -0.181307185019625 0.433017106049166 no 1921 0.428063233331825 2879 1955036 SGTC_3095 9117207 49.47 µM -0.181849496122128 0.432827279453884 no 1922 0.427850419887287 2868 17015229 SGTC_1653 st012112 65 µM -0.181956513263182 0.432789821789621 no 1923 0.4278084267531 2879 720429 SGTC_3336 9143619 71.43 µM -0.181998019666624 0.43277529406521 no 1924 0.42779214001246 2716 45595730 SGTC_2556 citropten 84.59 µM -0.182673225172172 0.43253897705344 no 1925 0.427527212723772 2729 2775 A potential DNA crosslinker. SGTC_3052 9092717 49.47 µM -0.182832464191731 0.432483248068941 no 1926 0.427464737597007 2897 25237534 SGTC_1043 0916-0009 19.3 µM -0.182975321557507 0.432433253325528 no 1927 0.427408691123013 2815 3101130 SGTC_673 1082-0474 110 µM -0.18389616323266 0.432111019119506 no 1928 0.427047457388456 2746 3098046 SGTC_2571 chrysanthemic acid 100 µM -0.185483840605479 0.431555542311559 no 1929 0.426424776840988 2799 2743 An insecticide. SGTC_1075 aripiprazole 15.2 µM -0.186202272069478 0.431304230852956 no 1930 0.426143071132643 2723 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2885 9057732 51.95 µM -0.186218968785636 0.43129839057585 no 1931 0.426136524594828 2888 6471414 SGTC_131 0141-0277 33.849 µM -0.187720364006973 0.430773285141018 no 1932 0.425547932944291 2901 1547771 SGTC_2221 6807166 181.081 µM -0.190970917216698 0.429636840931627 no 1933 0.424274189247817 2775 674925 SGTC_1388 3346-4487 254 µM -0.192010838899537 0.429273390659217 no 1934 0.423866857593316 2833 3345614 SGTC_3225 9130819 49.47 µM -0.192114750623209 0.42923707703656 no 1935 0.423826160399761 2821 4547121 SGTC_1570 verbenone 133 µM -0.192159826373882 0.429221324776917 no 1936 0.423808506662201 2908 29025 A natural terpanoid with antifungal properties. SGTC_1754 st042065 16.137 µM -0.192272641231097 0.429181900771251 no 1937 0.423764323844694 2797 1126236 YIL048W NEO1 SGTC_2066 5222451 176 µM -0.1927609309617 0.429011272379825 no 1938 0.423573101082877 2742 2281147 SGTC_2207 7258803 200 µM -0.193953580668485 0.428594567651197 no 1939 0.423106114442132 2838 3666799 SGTC_2079 5212404 121 µM -0.193964974959917 0.428590586936499 no 1940 0.423101653482779 2828 758462 SGTC_938 3126-1755 342 µM -0.194397339631071 0.42843954119535 no 1941 0.422932386427455 2865 1777771 SGTC_118 0083-0097 135.343 µM -0.196560834143839 0.427683886563596 no 1942 0.422085611215775 2787 5207356 SGTC_1791 st048313 56.1 µM -0.196876724261063 0.427573576150991 no 1943 0.421962004269069 2899 1204976 SGTC_1874 staurosporine 7.6 µM -0.199338893882059 0.426713968868509 no 1944 0.420998828351143 2885 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1879 gemcitabine 100 µM -0.202372029825617 0.425655501176947 no 1945 0.419812946483595 2789 60750 A nucleoside analog which inhibits DNA replication. SGTC_29 0299-0004 12.984 µM -0.202808251564494 0.425503317572991 no 1946 0.419642454075895 2739 16871 A napthoquinone isolated from Swertia calycina. SGTC_2935 9038016 29.96 µM -0.20367349021945 0.42520149675148 no 1947 0.419304329842745 2865 6463195 SGTC_565 1418-0001 44.5 µM -0.203956771450326 0.425102689400019 no 1948 0.419193640085012 2934 2862145 SGTC_1864 st057645 30.4 µM -0.204336460964655 0.424970262607708 no 1949 0.419045289633281 2772 688666 SGTC_2154 5570129 200 µM -0.205272707753899 0.424643757906249 no 1950 0.418679533035654 2747 673366 SGTC_2380 9035439 200 µM -0.206803110827465 0.424110159830146 no 1951 0.418081813290934 2926 6462575 SGTC_1194 1488-0194 225 µM -0.206822634671986 0.42410335344423 no 1952 0.41807418920682 2753 1391452 SGTC_2279 7948423 32.93 µM -0.207686755925345 0.423802126937224 no 1953 0.417736779722022 2939 1247112 SGTC_1451 4152-0210 104 µM -0.208082398308616 0.423664223670762 no 1954 0.417582315238076 2937 659563 SGTC_1287 0971-0001 34.6 µM -0.209224772391086 0.42326609560622 no 1955 0.417136387391541 2779 4665869 SGTC_1859 st055998 20 µM -0.209291694086794 0.423242775193733 no 1956 0.41711026768217 2856 676301 SGTC_2787 5284540 71.43 µM -0.210327711867113 0.422881785194233 no 1957 0.416705954025977 2862 736958 SGTC_951 1171-0579 82.7 µM -0.210396575840749 0.422857792525172 no 1958 0.416679082465041 2729 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3117 9124945 49.47 µM -0.210508928624622 0.42281864867801 no 1959 0.4166352418767 2745 17592065 SGTC_1806 st050005 60.3 µM -0.21118207548999 0.42258413946098 no 1960 0.416372598516609 2774 5194765 SGTC_106 0092-0003 11.579 µM -0.212488721283424 0.422129011862771 no 1961 0.415862887999822 2869 1072148 SGTC_2061 5245884 80.95 µM -0.21426538230361 0.421510336636874 no 1962 0.415170056025497 2772 573863 SGTC_2775 cyproheptadine 69.59 µM -0.21505147552994 0.421236662178446 no 1963 0.414863592815468 2842 2913 A selective serotonin reuptake inhibitor. SGTC_664 1222-0054 14.9 µM -0.215313642894257 0.421145398365073 no 1964 0.414761396789507 2805 6813991 SGTC_2703 st077852 53.4 µM -0.215583390861386 0.421051500069264 no 1965 0.414656251773707 2945 6281836 SGTC_1746 st038117 42 µM -0.216475330101576 0.420741051233305 no 1966 0.414308626497614 2895 2898218 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.217255111875954 0.420469680355178 no 1967 0.414004768559084 2800 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2284 7945075 39.21 µM -0.220456996027728 0.419355794235803 no 1968 0.412757630332479 2938 1245402 SGTC_2189 6047310 154.431 µM -0.221205718261421 0.419095418175516 no 1969 0.412466128507732 2774 711535 SGTC_945 3381-0768 11.3 µM -0.22240683568274 0.418677790967087 no 1970 0.41199859548443 2927 1126236 YIL048W NEO1 SGTC_127 0180-0333 59.125 µM -0.223339646724792 0.418353516785899 no 1971 0.411635586405573 2764 771601 SGTC_3146 9095609 49.47 µM -0.22383156054325 0.418182534546804 no 1972 0.411444185591636 2873 17173999 SGTC_1012 4112-3522 18 µM -0.223855055512605 0.418174368416601 no 1973 0.411435044362257 2958 3112398 SGTC_2450 5739737 12.93 µM -0.225668878463017 0.41754404596807 no 1974 0.410729482544628 2880 2262825 SGTC_171 k064-0041 9.68 µM -0.226335404189923 0.417312474437181 no 1975 0.410470282093699 2812 53325 SGTC_1455 4262-0120 131 µM -0.227516829462079 0.416902081488211 no 1976 0.410010942162535 3008 1529587 SGTC_138 0850-0259 40.9225 µM -0.22890941903799 0.416418452457192 no 1977 0.409469659798617 2894 6813004 SGTC_3212 9128307 49.47 µM -0.22922862891855 0.416307612633516 no 1978 0.409345611130536 2796 27243542 SGTC_3207 9114163 49.47 µM -0.229380615550476 0.416254840378857 no 1979 0.409286550548567 3090 849233 SGTC_3321 9137793 26.8275 µM -0.230730462657382 0.415786217644896 no 1980 0.408762103099578 2810 4904192 SGTC_773 4358-1457 44.6 µM -0.231617585576769 0.4154783027608 no 1981 0.408417523792721 2984 1186886 SGTC_2321 7390090 138.78 µM -0.231987833350236 0.415349807384692 no 1982 0.408273731815447 2900 649046 SGTC_859 0439-0102 54.6 µM -0.232177391163984 0.415284024394631 no 1983 0.408200118615287 2894 610143 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.232376757284279 0.415214840151745 no 1984 0.408122699936423 2821 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2890 9046729 58.44 µM -0.232452705133449 0.415188485339796 no 1985 0.40809320849581 2843 903329 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.232583852663424 0.41514297647697 no 1986 0.408042283597581 2910 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3121 9125696 49.47 µM -0.233012982644816 0.414994074142072 no 1987 0.407875662265062 2815 1235365 SGTC_1946 st076057 65.1 µM -0.233406255475349 0.414857624478729 no 1988 0.407722978071512 2801 953009 SGTC_2426 5582046 32.21 µM -0.233865837178661 0.414698181351735 no 1989 0.407544567889503 2984 2251934 SGTC_2610 ononetin 44.17 µM -0.235149908794388 0.414252771698407 no 1990 0.407046191452632 2882 259632 SGTC_3126 9127922 49.47 µM -0.235235025103498 0.414223251047107 no 1991 0.407013161249745 3075 45595682 SGTC_1934 st074720 32.6 µM -0.237226063110118 0.413532843499805 no 1992 0.406240708942289 2815 17250992 SGTC_2166 5933061 31.504 µM -0.237967785592354 0.413275713804695 no 1993 0.40595303995887 3333 2877375 SGTC_3185 9108267 49.47 µM -0.241875238881396 0.411921750593191 no 1994 0.404438418523208 2915 4910486 SGTC_1498 4478-3555 97.6 µM -0.242416939147286 0.411734129545116 no 1995 0.404228555106061 2846 3437919 SGTC_1166 k206-0078 225 µM -0.242822680482877 0.411593611880855 no 1996 0.404071382417755 2837 5404595 SGTC_3108 9121785 49.47 µM -0.243085830297545 0.41150248303793 no 1997 0.403969453917816 2755 17140271 SGTC_1351 1496-0003 46.5 µM -0.243288659264027 0.411432246576592 no 1998 0.403890894555925 2956 3891978 SGTC_2193 5925765 200 µM -0.243541429884748 0.411344720083618 no 1999 0.403792997305623 2950 877370 SGTC_2676 harmalol 100 µM -0.243652698384009 0.411306192710384 no 2000 0.40374990528282 2912 5459187 A monoamine oxidase inhibitor SGTC_82 0054-0107 293.755 µM -0.245172645054283 0.410779988020967 no 2001 0.403161378093247 2916 3104697 SGTC_2818 7996756 12.99 µM -0.24534824366114 0.410719206207616 no 2002 0.403093399974493 2789 2241621 SGTC_33 0986-0033 35.816 µM -0.24589872591429 0.410528675832341 no 2003 0.4028803150645 2840 2848082 SGTC_1998 st075797 76.8 µM -0.245976988251508 0.410501589746771 no 2004 0.402850023016589 2870 24208315 SGTC_2508 celastrol 40.54 µM -0.246206888541559 0.410422025221798 no 2005 0.402761041689737 2853 122724 Celastrol is a natural product and antioxidant. SGTC_904 1141-0088 396 µM -0.248393944636924 0.409665307633816 no 2006 0.401914809141567 2886 1378119 SGTC_130 0136-0219 337.655 µM -0.248501219758514 0.40962819926079 no 2007 0.401873313220697 2807 234244 SGTC_1134 3477-0009 42.5 µM -0.248974963564818 0.409464332536281 no 2008 0.401690073944049 3119 3973534 SGTC_1635 st007035 42.4 µM -0.249164463592666 0.409398789406926 no 2009 0.401616783313619 2863 3716403 SGTC_1663 st014140 55.4 µM -0.249543516286263 0.409267692542882 no 2010 0.401470192080882 2872 4207120 SGTC_1473 k844-0725 134 µM -0.249929873529278 0.409134079813561 no 2011 0.401320790225118 2877 54682906 SGTC_2141 5621638 7.665 µM -0.249933977378451 0.409132660648739 no 2012 0.401319203370485 2977 2856238 SGTC_2006 4011487 200 µM -0.250422152029289 0.408963851959997 no 2013 0.40113045020508 2997 45595294 SGTC_1276 0871-0068 94.2 µM -0.250871912035228 0.408808341832275 no 2014 0.400956570517054 2942 3414906 SGTC_1691 st019933 84.6 µM -0.25170727580828 0.408519542505168 no 2015 0.400633666378059 2889 6176082 SGTC_2263 7948595 193.29 µM -0.254893481043397 0.40741847502177 no 2016 0.399402685692178 2851 2971371 SGTC_622 1348-1566 26.3 µM -0.255045688111218 0.407365894549264 no 2017 0.399343905871901 2948 7340407 SGTC_2174 5790901 200 µM -0.255165824730946 0.407324394105569 no 2018 0.399297512732727 2942 786020 SGTC_1115 galangin 695.678 nM -0.25741598554974 0.406547282826224 no 2019 0.398428831946374 2958 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_195 4234-0266 16.654 µM -0.257426010488596 0.406543821453276 no 2020 0.398424962913565 2888 2303354 SGTC_458 nppb 133 µM -0.2600955448971 0.405622355406867 no 2021 0.397395037178178 3059 4549 A chloride channel blocker. SGTC_1694 st024011 44.9 µM -0.26159647163368 0.405104496924093 no 2022 0.39681628227348 2898 2787533 SGTC_1919 st067113 52.3 µM -0.264026934836627 0.404266277009173 no 2023 0.395879581975201 3007 1268243 SGTC_174 3553-0389 74.3 µM -0.264792279973677 0.404002414986316 no 2024 0.395584742187734 3015 738071 SGTC_2635 hydroquinidine 100 µM -0.265038085054521 0.403917679961904 no 2025 0.395490061475699 2851 442912 An experimental heart treatment. SGTC_1478 0453-0656 35.7 µM -0.265072559648704 0.40390579608637 no 2026 0.395476782832673 2919 5258496 SGTC_702 1488-0190 94 µM -0.266755400709884 0.403325805240791 no 2027 0.394828747651609 2968 949357 SGTC_413 propylparaben 100 µM -0.267595069861608 0.403036492846222 no 2028 0.394505513145922 2865 7175 A pharmaceutical preservative. SGTC_1052 3253-3998 198 µM -0.268152832118014 0.402844342272826 no 2029 0.394290840125388 2825 5450317 SGTC_2430 5571206 200 µM -0.268201743524886 0.402827493282042 no 2030 0.394272016503275 3046 1731771 SGTC_354 2783-3500 4.88 µM -0.269431210216268 0.40240402622228 no 2031 0.393798935783265 2905 6740761 SGTC_2664 lyso-paf C-16 73.48 µM -0.270453522423489 0.40205199685781 no 2032 0.393405684346112 2890 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1147 3809-1045 12.3 µM -0.27134841975411 0.401743907521875 no 2033 0.393061534636482 2899 325925 SGTC_112 phenothiazine 287.218 µM -0.271675860383512 0.401631193674122 no 2034 0.392935632010826 3009 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_322 k048-0136 19.3 µM -0.271881212019298 0.401560510307412 no 2035 0.392856678951903 2978 6823282 SGTC_1450 4112-4260 37.6 µM -0.272153800869112 0.40146668843037 no 2036 0.392751881514708 3040 1633175 SGTC_1209 2323-2347 50.3 µM -0.272952299941738 0.401191887147046 no 2037 0.39244494139897 2934 5412760 SGTC_1937 st074714 47.2 µM -0.273692096034656 0.400937331945082 no 2038 0.39216062618476 2839 17250970 SGTC_1089 terbinafine 2.25 µM -0.276063039270204 0.40012180190894 no 2039 0.391249824160856 3001 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_502 l-744,832 89.3 µM -0.276411506514494 0.400001976728545 no 2040 0.39111600997273 3007 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1677 st019204 53.9 µM -0.277577559352336 0.399601082192335 no 2041 0.390668330232952 3000 3945625 SGTC_3224 9130643 49.47 µM -0.277587437274053 0.399597686567102 no 2042 0.390664538445306 3096 17644395 SGTC_1876 myriocin 605 nM -0.27760614230488 0.399591256563811 no 2043 0.390657358268599 3067 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1168 k815-0004 80.5 µM -0.277686775696662 0.399563538505068 no 2044 0.390626406487588 2881 642433 SGTC_1903 st060211 78.3 µM -0.277958144495527 0.399470258088024 no 2045 0.390522244466554 3061 688960 SGTC_3170 9103054 49.47 µM -0.278450167069182 0.399301144694098 no 2046 0.390333406886992 2948 16432970 SGTC_1847 st056231 15 µM -0.278473220728854 0.399293221369127 no 2047 0.390324559558597 2893 5393180 SGTC_2102 5377816 72.7585 µM -0.278962005448589 0.399125240448851 no 2048 0.390136991482828 3086 1379702 SGTC_2856 9022925 19.48 µM -0.27973209079124 0.398860622691704 no 2049 0.389841527955962 3067 4944862 SGTC_509 pifithrin 175 µM -0.280046997676958 0.398752427348545 no 2050 0.389720723958233 2976 4817 A p53 inhibitor. SGTC_1204 4049-0315 18.3 µM -0.280160579748533 0.398713404860668 no 2051 0.389677154427343 3147 588402 SGTC_2057 5236571 38.335 µM -0.281412579192924 0.398283332556667 no 2052 0.389196985505303 3073 54684039 YBR257W POP4 SGTC_1494 4358-1428 177 µM -0.281453608874882 0.398269240604613 no 2053 0.389181252591658 3040 1564571 SGTC_538 2922-0838 53.3 µM -0.284249700916781 0.397309215349683 no 2054 0.38810951485859 3106 777039 SGTC_2262 9014885 67.46 µM -0.284926436321527 0.397076954618223 no 2055 0.387850250915925 2901 6457424 SGTC_3317 9138495 8.753 µM -0.285342691850899 0.396934110682598 no 2056 0.387690804179535 2915 17020139 SGTC_1843 st055809 45.5 µM -0.286300731825208 0.396605398362995 no 2057 0.387323898830544 3058 16413835 SGTC_1242 0402-0103 60.1 µM -0.287640441623403 0.39614585486644 no 2058 0.386810992293114 2885 432868 SGTC_1625 st003711 30.1 µM -0.288405312690813 0.395883555595695 no 2059 0.386518250743698 3113 24207034 YER133W GLC7 SGTC_1546 5-methoxyflavanone 78.7 µM -0.290596412814666 0.395132417121075 no 2060 0.385680001950989 2985 147795 SGTC_3164 9100705 49.47 µM -0.291530942466174 0.394812166169722 no 2061 0.385322641207527 3068 17174235 SGTC_1382 3002-2117 298 µM -0.293390074112274 0.394175277837096 no 2062 0.384612005763466 3076 1497314 SGTC_3018 9082602 49.47 µM -0.294399026580072 0.393829756245891 no 2063 0.384226505322957 2931 17332089 SGTC_2287 7945887 168.79 µM -0.29629926663302 0.393179235178796 no 2064 0.383500772981553 3025 1245853 SGTC_2844 9010103 25.97 µM -0.296699863288661 0.393042134410829 no 2065 0.383347830710088 3098 2480525 SGTC_1626 st003712 1.76 µM -0.297649027583417 0.392717344057092 no 2066 0.382985525486818 3094 24207035 SGTC_1369 1866-0067 208 µM -0.298828109746534 0.392313983160057 no 2067 0.382535600947171 3085 3531355 SGTC_1330 1469-0054 61.8 µM -0.29901574203789 0.392249805305237 no 2068 0.382464017171101 3073 7102664 SGTC_1615 st002656 86.5 µM -0.299593646715967 0.392052156884314 no 2069 0.382243565444853 2914 1584458 SGTC_863 0466-0191 129 µM -0.299930805333752 0.391936858568346 no 2070 0.382114968087537 3056 765160 YPR165W RHO1 SGTC_411 enrofloxacin 100 µM -0.300275515419017 0.391818987683189 no 2071 0.381983503931073 3094 71188 A bacterial gyrase inhibitor. SGTC_1984 st072354 53.1 µM -0.301116238755909 0.391531550652488 no 2072 0.381662929311579 2906 5762938 SGTC_3260 9137109 49.47 µM -0.301485682606691 0.39140525927651 no 2073 0.381522083029731 3009 17478346 SGTC_137 0438-0332 85.389 µM -0.30464141438794 0.390326965791773 no 2074 0.380319637114326 3015 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1116 jasmonic acid  1.58368 µM -0.305535039039297 0.390021772750643 no 2075 0.379979343826333 3098 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.306035818524866 0.389850774845919 no 2076 0.379788687027171 2950 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2681 menadione 3.18 µM -0.30704110842101 0.389507569439989 no 2077 0.379406041231184 3017 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2016 5121758 140 µM -0.307284598981771 0.389424454850558 no 2078 0.379313378613302 2879 2795203 SGTC_758 0868-0029 16 µM -0.30735574966645 0.38940016878604 no 2079 0.379286302861244 3065 762687 SGTC_2838 9002687 71.43 µM -0.308775423062376 0.38891567806576 no 2080 0.378746182876251 2918 6457060 SGTC_9 0092-0002 10.449 µM -0.309380649300506 0.388709185488642 no 2081 0.378515994230372 3002 759368 SGTC_3007 9078383 71.4286 µM -0.310486995670259 0.388331800817264 no 2082 0.37809532357344 2984 6496995 SGTC_1383 3049-0032 20.7 µM -0.310861268625696 0.388204156796392 no 2083 0.377953044901641 3098 712864 SGTC_2204 7233102 200 µM -0.311819657109835 0.387877358016592 no 2084 0.377588792076207 2970 2172480 SGTC_989 1501-0895 10.3 µM -0.314265239775003 0.38704380446483 no 2085 0.376659798209151 3063 2830112 SGTC_2194 5927483 104.545 µM -0.315214658393302 0.386720344259617 no 2086 0.376299338339587 2953 760979 SGTC_1583 clindamycin 39.6 µM -0.315632246542569 0.386578099831123 no 2087 0.37614082937652 2958 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2882 9058044 58.44 µM -0.316191508468279 0.386387620469464 no 2088 0.375928576320668 3042 18076804 SGTC_765 1319-0117 244 µM -0.316754149147147 0.38619601795928 no 2089 0.37571507881964 2947 3487746 YGL099W LSG1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.318317873812438 0.385663650664835 no 2090 0.375121913778245 3023 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2909 7941780 10.49 µM -0.318453642808642 0.385617438494728 no 2091 0.375070426662082 3122 1243215 SGTC_1790 st045711 43.5 µM -0.320596268886473 0.384888360726728 no 2092 0.374258182740406 3132 585119 SGTC_2036 5160441 105 µM -0.32077223619035 0.384828501850298 no 2093 0.374191500378745 3031 134534 YIL048W NEO1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.321494553732122 0.384582819544532 no 2094 0.373917819440376 2963 688803 SGTC_278 4092-0821 23.9 µM -0.324222502883302 0.383655379351369 no 2095 0.37288479332119 3046 877900 SGTC_1319 1306-0155 43.7 µM -0.327085112316442 0.382682874002154 no 2096 0.371801755859126 2973 3122360 SGTC_2280 7785178 200 µM -0.327844007284971 0.382425180706266 no 2097 0.371514805764923 2982 2954328 SGTC_439 amiodarone 34.4 µM -0.328389789633328 0.382239884927219 no 2098 0.371308481017134 2997 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2453 5731132 22.18 µM -0.328961246373764 0.382045901464294 no 2099 0.371092490081491 3139 1362040 SGTC_2367 9070478 135.38 µM -0.329097629762534 0.381999609907375 no 2100 0.371040947863672 2942 572802 SGTC_115 0527-0192 112.043 µM -0.329844941098005 0.381745985775104 no 2101 0.370758563916001 3083 4233931 SGTC_1231 0242-0792 125 µM -0.331274939109318 0.381260811530828 no 2102 0.370218409644639 2968 3707635 SGTC_1838 st055369 84.5 µM -0.331792041827302 0.381085413175606 no 2103 0.370023146957643 2973 676036 SGTC_268 camptothecin 39.6153 µM -0.333601333349884 0.380471904073203 no 2104 0.369340205989102 3078 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1258 0671-0043 57.1 µM -0.336249693806311 0.379574418982565 no 2105 0.36834129098971 3045 4298767 SGTC_2411 st077133 39.94 µM -0.33713061166293 0.379276034121102 no 2106 0.36800922102246 3280 1403142 YNL221C POP1 SGTC_1065 prochlorperazine maleate 2.48 µM -0.337847138519786 0.379033384866068 no 2107 0.367739192441879 3039 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3015 9080845 49.47 µM -0.338102345136926 0.378946971564488 no 2108 0.367643031671546 3131 5296973 SGTC_1036 k216-0215 33.5 µM -0.339046315903065 0.37862739440846 no 2109 0.367287419638112 2976 622330 SGTC_714 4296-0578 26.1 µM -0.340374266024371 0.378177963245341 no 2110 0.366787347866683 2992 1589775 SGTC_564 3555-0129 330 µM -0.341097339793622 0.377933315561281 no 2111 0.366515151905354 3027 563260 SGTC_323 4013-0906 34.3 µM -0.341114571588106 0.377927485883462 no 2112 0.366508665937678 3088 2910086 SGTC_2581 avocatin a 64 µM -0.341237910975345 0.377885759822714 no 2113 0.366462242676416 3044 6710728 A skin care supplement. SGTC_2220 6782180 200 µM -0.341251497580645 0.377881163523126 no 2114 0.366457128983151 3076 833803 SGTC_151 3013-0144 2.285 µM -0.341476288404953 0.377805120107372 no 2115 0.366372526204448 3187 906558 YHR107C CDC12 SGTC_1003 4049-0218 100 µM -0.341540113038398 0.377783530039518 no 2116 0.366348506205783 3160 295161 SGTC_1486 3970-0793 4.53 µM -0.341865368040911 0.377673511405518 no 2117 0.36622610666978 3085 2844330 SGTC_419 nsc-638432 893 µM -0.342754563168187 0.377372788738201 no 2118 0.365891555419101 3082 368090 SGTC_641 4092-0595 30 µM -0.343460882835179 0.377133966876468 no 2119 0.365625881971295 3083 786260 SGTC_285 1486-1325 46 µM -0.343952809880832 0.376967663522717 no 2120 0.365440887732288 3120 22310230 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.344937795365241 0.376634742955094 no 2121 0.365070567896852 2978 23665772 A membrane-active detergent. SGTC_454 lyso-paf C-16 6.67 µM -0.345051939071989 0.376596168833011 no 2122 0.365027662012661 3079 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_967 1306-0166 352 µM -0.345411173958882 0.37647477578612 no 2123 0.364892638962766 3171 4437607 SGTC_1355 1499-0035 1.68 µM -0.347546868380814 0.375753332154399 no 2124 0.364090257148305 3008 1548538 SGTC_1730 st033808 45.1 µM -0.348098100189017 0.375567194873464 no 2125 0.3638832555239 3008 1045166 SGTC_2858 9025781 8.96 µM -0.348917635487398 0.375290511717264 no 2126 0.363575572519783 3100 4894980 YPL153C RAD53 SGTC_1723 st034307 2.5525 µM -0.350264515942656 0.374835931058114 no 2127 0.363070096365947 3095 867466 SGTC_1863 st057641 20.1 µM -0.350341232606616 0.374810043926769 no 2128 0.363041312231128 3080 3921635 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.351726362461002 0.374342745372963 no 2129 0.362521743967166 3032 6708630 An antioxidant. SGTC_831 k061-1017 217 µM -0.352949762628669 0.373930162690407 no 2130 0.362063051655248 3103 1240153 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.356304370941072 0.372799587851508 no 2131 0.360806318154734 3053 688669 SGTC_1809 st050081 57.6 µM -0.356947729092368 0.372582887197529 no 2132 0.360565468728312 3191 5036894 SGTC_248 streptozotocin 5.23457 mM -0.357657862111969 0.372343741761526 no 2133 0.360299685483191 3125 5300 DNA alkylating agent. SGTC_425 3825-7017 13.1 µM -0.357951869170603 0.372244745915079 no 2134 0.360189666483127 3259 3397440 SGTC_1415 3966-0071 78.1 µM -0.358265608204608 0.372139115377465 no 2135 0.36007227644293 3102 2893185 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.359351986961283 0.371773424712454 no 2136 0.35966589397716 3196 688798 SGTC_533 1222-0222 6.71 µM -0.361533263189571 0.37103952542079 no 2137 0.358850421834519 3203 3982874 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.363089925519151 0.370516066503168 no 2138 0.358268855052809 3189 16725076 SGTC_2069 5228469 200 µM -0.364575812979998 0.370016630569746 no 2139 0.357714036183944 3151 2835210 SGTC_2331 7980721 200 µM -0.364942153038402 0.369893530126495 no 2140 0.357577293775251 3083 2981221 SGTC_3059 1327-0034 3 µM -0.367975364885047 0.368874799815305 no 2141 0.356445801682913 3049 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2341 7987486 176.74 µM -0.369307051356878 0.368427831819146 no 2142 0.355949435128554 3213 1258686 SGTC_2490 carminic acid 95.39 µM -0.372055988468823 0.36750574051886 no 2143 0.354925581953281 3038 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3097 9117246 49.47 µM -0.373882729174012 0.366893408525686 no 2144 0.354245783135442 3059 16423892 SGTC_1829 berberine 14.4 µM -0.375229441142441 0.366442201071099 no 2145 0.353744918140795 3218 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1644 st010134 20.9 µM -0.375653054327233 0.366300310238513 no 2146 0.353587421499341 3194 3818134 SGTC_1772 st048439 82.2 µM -0.376210767351896 0.366113530033027 no 2147 0.353380105625192 3151 2927068 YDL195W SEC31 SGTC_1476 4112-3294 3.34 µM -0.376426997111876 0.366041122397882 no 2148 0.353299739315031 3194 704369 SGTC_876 0720-0963 56.8 µM -0.376499953091643 0.366016693118303 no 2149 0.353272625175792 3238 765861 SGTC_2657 nystatin 74.44 µM -0.376786770601971 0.365920657659848 no 2150 0.353166036474568 3125 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2438 5259590 200 µM -0.378344220507461 0.365399321596542 no 2151 0.352587449653416 3164 1201127 SGTC_2623 humulene 100 µM -0.381312366691743 0.364406462352535 no 2152 0.351485739162363 3144 6187145 An anti-inflammatory. SGTC_3262 9137218 49.47 µM -0.382040272784938 0.364163112797407 no 2153 0.351215746417321 3031 17650664 SGTC_2409 alverine citrate 63.97 µM -0.385145306919563 0.363125670940422 no 2154 0.350064881089106 3301 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1435 4092-0789 56.7 µM -0.385626962215713 0.362964831868727 no 2155 0.349886480962968 3171 2248285 SGTC_3267 9137951 49.47 µM -0.386492676157912 0.362675804932143 no 2156 0.349565912815798 3025 16643986 SGTC_1525 8-methoxypsoralen 92.5 µM -0.386739144156735 0.362593533516208 no 2157 0.349474666948962 3303 4114 Related to psoralen; DNA damaging agent. SGTC_1447 4239-0816 81.9 µM -0.387147660928656 0.362457183931494 no 2158 0.349323447538242 3082 1341554 SGTC_713 1488-1073 324 µM -0.387378417819701 0.362380172510489 no 2159 0.349238039529916 3123 3312542 SGTC_1509 1326-1131 80 µM -0.387786197370221 0.36224409622594 no 2160 0.349087130357395 3192 768313 SGTC_1938 st074717 56.4 µM -0.387915475063608 0.362200959813888 no 2161 0.349039292846273 3046 17250979 SGTC_2697 mebhydrolin 72.4 µM -0.389076682511492 0.361813575324585 no 2162 0.348609710923305 3258 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_665 3914-0008 307 µM -0.389549809052694 0.361655778559008 no 2163 0.348434736127619 3080 1069549 SGTC_1039 k821-0043 94 µM -0.389738823698135 0.361592745128068 no 2164 0.34836484249027 3220 15992768 SGTC_1972 st070201 17.4 µM -0.39024259000971 0.361424765283217 no 2165 0.348178585465181 3212 2829099 SGTC_3138 9097216 49.47 µM -0.391681896947803 0.360944978598573 no 2166 0.347646633795112 3141 25237486 SGTC_867 0518-0118 155 µM -0.394077715076999 0.360146828446973 no 2167 0.346761831659967 3202 6848158 SGTC_1197 1601-0112 267 µM -0.394327893722721 0.360063518242626 no 2168 0.346669485993112 3082 7350313 SGTC_3111 9122088 49.47 µM -0.394334936489191 0.360061173077417 no 2169 0.346666886506699 3111 16876704 SGTC_2840 9008771 71.43 µM -0.395867411969908 0.35955100068373 no 2170 0.34610142140383 3173 2992978 SGTC_1852 st056254 31.4 µM -0.396493589545324 0.359342613505887 no 2171 0.3458704680044 3088 442583 SGTC_807 1315-0151 48 µM -0.397533847905177 0.35899651585873 no 2172 0.345486915750577 3313 4011080 SGTC_884 0851-0618 334 µM -0.398082617407518 0.358813984899588 no 2173 0.345284643560787 3197 9642473 SGTC_2636 apigenin dimethyl ether 100 µM -0.398561202177769 0.358654825004374 no 2174 0.345108276985986 3245 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2274 7947094 46.08 µM -0.399096931733476 0.358476689946262 no 2175 0.344910891496148 3091 2971028 SGTC_1574 spiramycin 23.7 µM -0.39921501913788 0.358437428926508 no 2176 0.344867388762199 3055 6419898 An antibiotic and protein synthesis inhibitor. SGTC_955 1216-0110 33 µM -0.399801938828019 0.358242315457822 no 2177 0.344651201294186 3102 3619719 SGTC_3189 9110682 49.47 µM -0.3999574413803 0.358190626949152 no 2178 0.344593931591925 3205 17122418 SGTC_1527 coumarin 137 µM -0.401082601563068 0.357816705095602 no 2179 0.344179654949993 3271 323 A hepatotoxic, DNA x-linker. SGTC_3235 9132602 49.47 µM -0.401385261796341 0.357716145992026 no 2180 0.344068249308985 3224 4912240 SGTC_1040 k898-0338 155 µM -0.401701032091605 0.357611241585781 no 2181 0.343952032434939 3297 20969351 SGTC_2671 danthron 100 µM -0.401761580507601 0.357591127573404 no 2182 0.343929749731325 3173 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2467 5474540 200 µM -0.402649567192109 0.357296186372969 no 2183 0.343603019932709 3100 5413519 SGTC_3047 9092122 49.47 µM -0.404622058021959 0.356641336654911 no 2184 0.342877671018404 3166 17173831 SGTC_1787 fluconazole 80 µM -0.406448599419015 0.356035317412209 no 2185 0.342206508433579 3213 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1346 1488-2224 62.4 µM -0.407401196164104 0.355719404127504 no 2186 0.341856674288659 3230 3722427 SGTC_2764 methyldopa 94.69 µM -0.408886269869146 0.355227101157064 no 2187 0.341311562756527 3296 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2237 6667747 47.222 µM -0.40892842654376 0.355213129711624 no 2188 0.341296093542102 3065 729940 YDL015C TSC13 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.409378511145555 0.355063976085402 no 2189 0.341130953517442 3134 364106 SGTC_97 0535-0701 19.132 µM -0.409763716924255 0.35493634029965 no 2190 0.340989642268827 3139 2832013 YGL099W LSG1 SGTC_2005 4024620 188 µM -0.41079355497826 0.354595189175164 no 2191 0.34061195973308 3127 236743 SGTC_2182 6325192 200 µM -0.410831517540309 0.354582615666609 no 2192 0.340598040403915 3234 736248 SGTC_3213 9129884 49.47 µM -0.412047816443655 0.354179851533116 no 2193 0.340152188003356 3185 17190742 SGTC_284 0988-0104 32.6 µM -0.412239476523586 0.354116400246265 no 2194 0.340081952518976 3187 4666532 SGTC_984 1492-0255 2.91 µM -0.412477302494735 0.354037670838491 no 2195 0.339994806862013 3212 1585198 SGTC_1008 4106-0037 6 µM -0.414976675763706 0.353210661519008 no 2196 0.33907948887901 3055 2905394 SGTC_128 0906-2981 13.371 µM -0.415640188982815 0.352991230035975 no 2197 0.338836656919011 3289 6740226 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.417320792991736 0.352435653734767 no 2198 0.338221890796586 3165 688664 SGTC_51 1013-0126 23.419 µM -0.417546258296477 0.352361143030494 no 2199 0.338139448189567 3396 1627850 SGTC_1293 1000-1278 195 µM -0.418110072557759 0.352174841173275 no 2200 0.337933320435645 3258 678847 SGTC_3158 9100007 49.47 µM -0.418402127576911 0.352078351008181 no 2201 0.337826565638682 3135 19297233 SGTC_2739 tacrine 100.86 µM -0.419119483996913 0.351841388703558 no 2202 0.337564405912743 3243 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2471 5466956 24.79 µM -0.419371890034084 0.351758025815319 no 2203 0.337472182222557 3115 724419 SGTC_1224 0823-0416 294 µM -0.419734667002983 0.351638222876725 no 2204 0.337339648487104 3268 3598164 SGTC_3293 9120939 62.045 µM -0.420795594219235 0.351287948399525 no 2205 0.336952174554729 3267 934087 SGTC_1508 1080-0625 72.9 µM -0.420963386420065 0.351232561882132 no 2206 0.336890908985591 3177 767111 SGTC_1163 k060-0048 49.9 µM -0.423640886559026 0.350349174199083 no 2207 0.335913866117511 3148 6809982 SGTC_2724 maprotiline 69.64 µM -0.423695242701596 0.350331248837577 no 2208 0.335894042544648 3282 4011 A tricyclic antidepressant. SGTC_1263 0774-1208 64.8 µM -0.424112412114864 0.35019368739842 no 2209 0.335741916922727 3327 906585 SGTC_2317 5986382 200 µM -0.424843207172724 0.34995275541115 no 2210 0.335475488984884 3201 877883 SGTC_1289 0976-0073 69.1 µM -0.42525554216198 0.34981684149852 no 2211 0.335325199388519 3247 3391136 SGTC_593 1203-0218 61.7 µM -0.425280151779942 0.349808730281399 no 2212 0.33531623040422 3274 3666956 SGTC_484 loperamide 105 µM -0.425313874308383 0.349797615602136 no 2213 0.335303940368797 3160 3955 An opioid-receptor agonist. SGTC_1600 coumarin 106 71.1 µM -0.425659007010905 0.349683869988493 no 2214 0.335178168324622 3309 100336 A hepatotoxic, DNA x-linker. SGTC_1027 k015-0025 8.67 µM -0.426518359558067 0.349400711239208 no 2215 0.33486508639503 3120 3598955 SGTC_1006 4099-6547 255 µM -0.427865488913821 0.348956997522923 no 2216 0.334374527109524 3269 3146833 SGTC_2211 7117706 200 µM -0.429185296752931 0.348522483089967 no 2217 0.333894191123489 3236 822771 SGTC_424 splitomicin 100 mM -0.429643334549452 0.348371731764505 no 2218 0.333727554616004 3206 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1340 1486-1359 257 µM -0.430735923600763 0.348012230997595 no 2219 0.333330197543692 3173 4309068 SGTC_298 1391-0729 10 µM -0.430991342381837 0.347928208790846 no 2220 0.333237332786938 3151 3237558 SGTC_1514 1189-1591 158 µM -0.431201381013022 0.347859120369303 no 2221 0.333160974932492 3327 767698 YMR146C TIF34 SGTC_3002 9075603 71.4286 µM -0.431780678146162 0.347668597202751 no 2222 0.332950411967317 3222 20105405 SGTC_987 1497-1013 404 µM -0.431782291657402 0.347668066593939 no 2223 0.332949825561647 3259 1676435 SGTC_1547 harmine 94.2 µM -0.433438206568642 0.347123670655843 no 2224 0.332348224515467 3205 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_373 0844-0104 25.9 µM -0.43499227964275 0.346613042867311 no 2225 0.331784015656919 3291 5375804 SGTC_1944 st076371 56.9 µM -0.435167326457217 0.346555544498161 no 2226 0.331720488486332 3136 24208455 SGTC_1160 4092-0570 10.5 µM -0.437456897236403 0.345803805418612 no 2227 0.330890014332968 3176 4994975 SGTC_1793 st048256 72.231 µM -0.437820183626594 0.345684582681401 no 2228 0.330758319260502 3212 672022 SGTC_1020 4335-0961 93.3 µM -0.438690411291131 0.345399055032282 no 2229 0.330442937939611 3118 669075 SGTC_2624 nerol 100 µM -0.439204331796786 0.345230475497253 no 2230 0.330256743285186 3185 637566 A natural product oil. SGTC_2699 st077704 54.6 µM -0.440775754161302 0.344715197950487 no 2231 0.329687673986097 3237 645852 SGTC_1023 4482-3888 16 µM -0.442178677902909 0.344255415213024 no 2232 0.329179957060368 3330 3303168 SGTC_2937 9044753 11.33 µM -0.445905361813332 0.343035181320725 no 2233 0.327832804499579 3161 6465530 YGL099W LSG1 SGTC_3062 9077494 49.47 µM -0.447242885541409 0.342597631922747 no 2234 0.327349850020797 3287 16459633 SGTC_1429 4049-0205 9.46 µM -0.448908136353046 0.342053166956902 no 2235 0.32674896321639 3259 22774478 SGTC_3085 9117376 49.47 µM -0.449191659070205 0.3419604999663 no 2236 0.326646701966747 3290 16480349 SGTC_328 k915-0120 63.5 µM -0.450103172870534 0.341662643949699 no 2237 0.326318024549829 3281 6624543 SGTC_1846 st056244 14.8 µM -0.452925769898974 0.340740927736298 no 2238 0.325301096937585 3238 5393182 SGTC_3064 1327-0027 10 µM -0.454115838173045 0.340352596535475 no 2239 0.324872727147661 3216 16000455 YPR107C YTH1 SGTC_611 3453-1652 23.7 µM -0.454766464875527 0.340140362047044 no 2240 0.324638629312079 3312 1560575 SGTC_142 0335-0849 62.6745 µM -0.45626672473815 0.339651170246807 no 2241 0.324099094492955 3362 3889043 YPR107C YTH1 SGTC_2751 anetholtrithion 17.25 µM -0.456408668030075 0.339604900570118 no 2242 0.324048066873465 3305 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1464 k208-0027 110 µM -0.457554155457585 0.339231591146682 no 2243 0.323636393214954 3385 X1464 SGTC_636 0kpi-0074 126 µM -0.458868971829718 0.338803292612665 no 2244 0.323164130804592 3249 616434 SGTC_1511 0906-3109 28.5 µM -0.46106451478851 0.33808856392914 no 2245 0.322376159824 3270 2882180 SGTC_1290 0986-0249 10.2 µM -0.461783432776781 0.33785465672732 no 2246 0.322118316353924 3249 53329 SGTC_3253 9135987 49.47 µM -0.461866558158568 0.337827615083927 no 2247 0.32208850854525 3297 4182430 SGTC_448 monastrol 171 µM -0.462581188266948 0.337595172228006 no 2248 0.321832297609372 3262 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1651 st011928 86.1 µM -0.463114320838683 0.337421804174622 no 2249 0.321641212762048 3307 720198 SGTC_2942 9052777 62.25 µM -0.46421265172553 0.337064749494459 no 2250 0.321247698841331 3251 6469503 SGTC_2184 6075246 200 µM -0.464339106818928 0.337023649818955 no 2251 0.32120240492743 3275 2267320 SGTC_1096 rimcazole 32.2 µM -0.466609519724642 0.336286065291049 no 2252 0.320389637402782 3197 18528119 A dopamine reuptake inhibitor. SGTC_602 3130-1533 38.1 µM -0.467877917376544 0.335874277434996 no 2253 0.319935948031534 3335 720941 SGTC_661 1304-0007 33.6 µM -0.469427717825559 0.335371398959637 no 2254 0.319381969953278 3259 3117130 SGTC_236 1509-0011 5.31 µM -0.470805439648457 0.33492460396532 no 2255 0.318889839826224 3393 3107280 SGTC_156 3474-0145 5.642 µM -0.47159372609128 0.334669067777335 no 2256 0.3186084028736 3334 2265471 SGTC_2980 9014342 25.29 µM -0.472111996409445 0.334501103519749 no 2257 0.318423425067169 3369 2996599 SGTC_569 4130-2812 160 µM -0.473800285536413 0.333954182133648 no 2258 0.31782116547825 3271 743552 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.473950953608585 0.333905390316482 no 2259 0.317767441381262 3251 689007 SGTC_1740 st038286 13.222 µM -0.474345311103941 0.333777696269993 no 2260 0.317626842491546 3390 716786 SGTC_2202 7226349 200 µM -0.476223915005672 0.333169663604231 no 2261 0.316957431776389 3213 844334 SGTC_499 genistein 192 µM -0.477349232225437 0.332805650967494 no 2262 0.316556729397022 3331 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3345 9148410 3.559 µM -0.477920786756606 0.332620827340339 no 2263 0.316353292930677 3328 4903596 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.478531946828487 0.332423241469369 no 2264 0.316135820924689 3305 75037 A free radical scavenger. SGTC_1017 4239-0030 168 µM -0.479381711129243 0.332148593080806 no 2265 0.315833550930218 3236 1149593 SGTC_2371 9071574 200 µM -0.479733332676441 0.33203497346374 no 2266 0.315708511490958 3328 45596039 SGTC_472 calcifediol 10 µM -0.480154291244407 0.331898969256012 no 2267 0.315558842991435 3294 5283731 A vitamin D metabolite. SGTC_311 1315-0136 58 µM -0.485379959363752 0.330212497864652 no 2268 0.313703422769885 3403 6759207 SGTC_2695 st077686 51.995 µM -0.486825853576924 0.329746473529292 no 2269 0.313190873612006 3286 2876092 SGTC_1578 josamycin 24.2 µM -0.486860309220518 0.329735371394443 no 2270 0.313178663967439 3241 5282165 A P450 substrate. SGTC_1469 k284-2957 126 µM -0.488730924505533 0.329132855951437 no 2271 0.31251610354398 3298 23884841 SGTC_3329 9141233 27.5565 µM -0.490064906427558 0.328703458160552 no 2272 0.312043985085594 3384 4909101 YNL103W MET4 SGTC_545 4218-0007 221 µM -0.490916184683651 0.328429556820308 no 2273 0.311742864739189 3353 2840508 SGTC_1645 Cervolide 78 µM -0.493725904816572 0.327526175797684 no 2274 0.310749883895434 3326 23173 A fragrance. SGTC_568 1193-0097 7.48 µM -0.493786958093778 0.327506557133026 no 2275 0.310728322366913 3292 3646150 SGTC_963 1269-2853 151 µM -0.494058814515124 0.327419205443893 no 2276 0.310632321653782 3256 3668223 SGTC_1050 3232-1156 69.3 µM -0.494073066891927 0.327414626194547 no 2277 0.310627289064719 3277 700529 SGTC_1215 3852-0577 11.2 µM -0.494313609548239 0.327337344420818 no 2278 0.310542357536954 3400 2884876 SGTC_829 1635-0120 117 µM -0.49502234262273 0.327109685015467 no 2279 0.310292174644135 3381 285054 SGTC_1376 2910-0861 41.3 µM -0.4957327984298 0.32688153678029 no 2280 0.310041471705183 3315 1112859 SGTC_75 0159-0059 199.013 µM -0.495744781672319 0.326877689163638 no 2281 0.310037243861017 3507 5377270 SGTC_2308 7584454 197.62 µM -0.496515834279309 0.326630155913552 no 2282 0.30976525927102 3449 893577 SGTC_1246 0422-0085 105 µM -0.497305154617798 0.32637683715412 no 2283 0.309486938675195 3403 264295 SGTC_2591 skatole 100 µM -0.498180682478161 0.326095945231113 no 2284 0.309178348405258 3361 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_704 1310-0270 142 µM -0.498545625003995 0.325978891372525 no 2285 0.309049759771449 3323 5718033 SGTC_407 eburnamonine 100 µM -0.498563101885613 0.325973286162669 no 2286 0.309043602324734 3276 3195 SGTC_889 0919-1524 82.7 µM -0.500113361040962 0.325476241469191 no 2287 0.308497629365196 3341 3905452 SGTC_2152 5568786 200 µM -0.503051162551817 0.324535173890684 no 2288 0.307464150829695 3328 5399883 SGTC_2786 7743617 45.45 µM -0.50367936579011 0.324334086255646 no 2289 0.30724335533673 3272 583674 SGTC_1973 st070275 50.2 µM -0.504561278302188 0.324051872805559 no 2290 0.30693350616028 3339 17118334 SGTC_1341 1486-1360 280 µM -0.505041845638891 0.32389813300792 no 2291 0.306764722714293 3260 3976547 SGTC_218 alverine citrate 93.75 µM -0.507778760852711 0.323023131219765 no 2292 0.305804253175413 3405 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_403 arphamenine a 50 µM -0.50783415458772 0.323005431727375 no 2293 0.30578482752715 3337 5487158 An arginine aminopeptidase inhibitor. SGTC_38 0929-0051 58.268 µM -0.508951470571406 0.322648510804847 no 2294 0.305393120395522 3348 1379719 SGTC_362 0310-0100 9.03 µM -0.509027234599887 0.322624314280647 no 2295 0.305366567202424 3375 790235 SGTC_1720 st037298 9.481 µM -0.510118752337309 0.322275803030387 no 2296 0.304984134177932 3358 597396 SGTC_2106 5357045 167.29 µM -0.515373292836055 0.320600268072059 no 2297 0.303146095739825 3347 668842 SGTC_1898 st060199 18.6 µM -0.516055318016602 0.320383055001291 no 2298 0.302907886985332 3350 688866 SGTC_1534 6-azauridine 81.6 µM -0.516564857827875 0.320220815642534 no 2299 0.3027299763469 3318 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_803 4488-1585 147 µM -0.516715018235371 0.320173010568048 no 2300 0.302677555352932 3385 747204 SGTC_1046 2001-0062 216 µM -0.521827882386419 0.318547064369018 no 2301 0.300895087215131 3345 739778 SGTC_621 3584-0052 32.1 µM -0.524196554757555 0.31779498115779 no 2302 0.300070918464997 3431 2273927 SGTC_1701 st028638 40.4 µM -0.525981864726328 0.317228618999026 no 2303 0.299450403722996 3422 3490878 SGTC_2160 5660466 132.927 µM -0.527409144120452 0.316776144140634 no 2304 0.298954747435456 3393 2859134 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.528713763005109 0.316362794626104 no 2305 0.298502014139714 3342 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1399 3562-5772 25 µM -0.528737246835873 0.3163553562156 no 2306 0.298493867559214 3358 23847490 SGTC_492 tmb-8 126 µM -0.530316866319449 0.315855188703991 no 2307 0.2979461272951 3341 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_929 2805-0021 398 µM -0.530371516597649 0.315837890376394 no 2308 0.297927185264558 3407 3098024 SGTC_1304 1165-0502 251 µM -0.531308188895903 0.315541470358798 no 2309 0.297602615841464 3326 767425 SGTC_992 3909-8734 162 µM -0.532444553227027 0.315182014941229 no 2310 0.297209067286397 3348 4288319 SGTC_1107 amlodipine 47 µM -0.532551547948166 0.315148179314405 no 2311 0.297172024861389 3372 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1216 1165-0504 9.65 µM -0.533542483908107 0.31483488300252 no 2312 0.296829055270306 3441 6304004 SGTC_721 1187-1332 279 µM -0.535610713039023 0.314181416872411 no 2313 0.296113811589115 3334 25730 SGTC_1606 st000094 49.2 µM -0.539152332384542 0.313063779054518 no 2314 0.294890874140666 3471 1242210 SGTC_2047 4141938 200 µM -0.539165280400403 0.313059696157497 no 2315 0.294886407404764 3343 3807862 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.539417688840458 0.312980108799544 no 2316 0.294799339147131 3402 16623 A steroid. SGTC_1996 st072960 66.8 µM -0.540936513638503 0.312501389516045 no 2317 0.294275671142807 3464 1719405 SGTC_3247 9135149 49.47 µM -0.541313569161503 0.312382594128894 no 2318 0.294145734657064 3375 8934436 YOR116C RPO31 SGTC_2986 9022445 71.43 µM -0.542554676410074 0.31199170774047 no 2319 0.293718226090338 3438 6459286 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.542657272278931 0.311959404663753 no 2320 0.293682899056139 3434 165521 SGTC_280 3448-3607 3.04 µM -0.543995225114003 0.311538272686034 no 2321 0.293222379326968 3440 626179 SGTC_3222 9128301 49.47 µM -0.544188439194594 0.311477477269236 no 2322 0.293155903238916 3337 4911358 SGTC_1207 2099-0101 141 µM -0.544860291017013 0.311266117004113 no 2323 0.29292480431167 3426 5837381 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.544908534398146 0.31125094233955 no 2324 0.292908213142188 3360 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3203 9113543 49.47 µM -0.545074589922244 0.311198713028295 no 2325 0.292851109050092 3439 17018012 SGTC_2032 5185112 25.99 µM -0.547680646100849 0.310379530750424 no 2326 0.291955601786734 3350 5718189 SGTC_2363 9053361 176 µM -0.547912690668831 0.310306635848016 no 2327 0.291875927227609 3508 6469797 YMR079W SEC14 SGTC_772 k072-0172 35.3 µM -0.549150300258514 0.309917976830117 no 2328 0.291451154159358 3360 5861980 SGTC_844 0330-0132 15.3 µM -0.550118875132387 0.309613953580903 no 2329 0.291118920624963 3469 2828079 SGTC_1378 2093-0007 380 nM -0.550636668203376 0.30945147836784 no 2330 0.290941383578638 3417 3618014 SGTC_1792 st045773 43.6 µM -0.552600982065976 0.308835446806565 no 2331 0.290268334686666 3397 2919270 SGTC_3076 9116187 49.47 µM -0.55436303227923 0.308283304625792 no 2332 0.289665210263979 3406 27241210 SGTC_443 clozapine 122 µM -0.554428401451248 0.308262829387979 no 2333 0.289642846657369 3402 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2592 piperlongumine 83.33 µM -0.554676131800782 0.308185239543697 no 2334 0.289558102380774 3382 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1676 st018489 23.4 µM -0.554897279164569 0.308115982805603 no 2335 0.289482461521418 3390 3696235 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.557772251424248 0.307216249943544 no 2336 0.288499956604887 3478 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1668 st014914 51.6 µM -0.557775782256142 0.307215145668737 no 2337 0.288498750930524 3466 2839556 SGTC_3107 9121808 49.47 µM -0.558026081473338 0.307136868537827 no 2338 0.288413287223115 3443 662681 SGTC_105 0111-0055 734.78 µM -0.559940102857918 0.306538579298244 no 2339 0.287760146859673 3428 5179370 SGTC_3081 9117243 49.47 µM -0.560589064354304 0.306335842292247 no 2340 0.287538854075436 3504 45595589 SGTC_874 0599-0792 117 µM -0.562590596277679 0.305710932835914 no 2341 0.286856848446221 3506 765305 SGTC_2063 5246145 200 µM -0.56277762116689 0.305652569607469 no 2342 0.286793160426714 3477 711240 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.56301047001559 0.305579913394799 no 2343 0.286713877235869 3535 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3137 9097352 49.47 µM -0.564612419947043 0.305080261913728 no 2344 0.286168707823644 3582 44120435 SGTC_798 1287-0182 476 µM -0.564763191291295 0.30503325470314 no 2345 0.286117423264276 3510 1649755 SGTC_371 0195-0006 7.36 µM -0.567646921041568 0.304134790650116 no 2346 0.28513736998576 3393 3928593 SGTC_1958 st076513 41.9 µM -0.569677176590199 0.303502945992909 no 2347 0.284448336384595 3372 732122 YGL099W LSG1 SGTC_167 3672-0051 66.205 µM -0.569963655159816 0.30341383697216 no 2348 0.284351174592958 3436 3237971 SGTC_1156 4092-0367 4.88 µM -0.570687273123248 0.303188808024977 no 2349 0.284105823685085 3433 1357585 SGTC_2267 7931562 200 µM -0.571795373784662 0.302844358314567 no 2350 0.28373030590506 3336 934880 SGTC_2707 st078556 66.6 µM -0.573161964663101 0.302419799175953 no 2351 0.283267517468672 3423 17250899 SGTC_2188 6126565 140.678 µM -0.573603435878772 0.302282704262233 no 2352 0.283118093092161 3460 874518 SGTC_1443 4112-3303 14 µM -0.573850461202131 0.30220600493962 no 2353 0.283034499153414 3463 704433 SGTC_1314 1222-0010 41.1 µM -0.574370797430825 0.302044473421472 no 2354 0.282858454944915 3439 3526027 SGTC_1560 lithocholic acid 53.1 µM -0.57588812543851 0.301573660498108 no 2355 0.28234540118689 3444 9903 A bile acid which acts as a detergent. SGTC_1108 betulinic acid 729.144 nM -0.576165947255104 0.301487490714779 no 2356 0.282251509875448 3437 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.576964701438115 0.301239809225405 no 2357 0.281981650523367 3489 66535 A nucleotide analog. SGTC_3046 9092212 49.47 µM -0.577461057081421 0.3010859430973 no 2358 0.28181401924453 3482 25236637 SGTC_676 falcarinol 140 µM -0.577831751845112 0.300971053907172 no 2359 0.281688858012389 3560 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2089 5281248 129.67 µM -0.578711613413431 0.300698438143517 no 2360 0.281391889248188 3506 2737878 SGTC_1756 st041558 35.5 µM -0.579328226286245 0.300507453635163 no 2361 0.281183861637456 3565 3955792 SGTC_3307 9126885 69.2785 µM -0.58015117503256 0.300252645766144 no 2362 0.280906337944411 3426 24824909 SGTC_3239 9133757 49.47 µM -0.580226213554902 0.300229416607806 no 2363 0.280881039229028 3468 17036923 SGTC_449 xestospongin c 11.1929 µM -0.58106472435508 0.299969899881002 no 2364 0.280598416094911 3469 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_349 k015-0014 24 µM -0.583189623505639 0.299312704610179 no 2365 0.279882827838427 3416 2196908 SGTC_999 SEC7.066 22.7 µM -0.584480569263832 0.298913756180138 no 2366 0.279448517177873 3482 740511 YDR170C SEC7 SGTC_279 1273-0055 2.93 µM -0.58489335530444 0.298786241510872 no 2367 0.279309713376178 3485 2847562 SGTC_716 1683-5115 658 µM -0.584997976502665 0.298753926667332 no 2368 0.279274538680846 3538 723597 SGTC_1888 azatryptophan 97.5 µM -0.585465677210595 0.298609485169345 no 2369 0.279117319341919 3473 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_531 3788-1495 174 µM -0.586800732566478 0.298197350597562 no 2370 0.278668772379419 3456 2896655 SGTC_2919 7978188 46.38 µM -0.588029474649092 0.297818264276834 no 2371 0.27825625456075 3527 2980291 SGTC_1102 cgs 12066b 26.1 µM -0.588155429034514 0.297779417784254 no 2372 0.278213985519982 3457 6438352 A 5-HT1B full agonist. SGTC_1128 3448-9350 235 µM -0.589906371765861 0.297239636578305 no 2373 0.277626711040239 3427 619386 SGTC_1172 0370-0043 85 µM -0.589999062229628 0.297211074398217 no 2374 0.277595639106559 3530 376585 SGTC_671 0560-0003 407 µM -0.590638349790115 0.297014114773004 no 2375 0.277381381783272 3419 3238678 SGTC_541 4513-1321 94 µM -0.591844546827869 0.296642657341087 no 2376 0.276977344989531 3424 747515 SGTC_818 4072-2707 53.5 µM -0.592043464295445 0.296581419657079 no 2377 0.276910741790109 3456 882871 SGTC_1073 triclabendazole 3.09 µM -0.592277217012593 0.296509465178816 no 2378 0.276832484786918 3512 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2886 9058944 51.95 µM -0.593637090004994 0.296091023627556 no 2379 0.27637743405552 3347 4949929 SGTC_2478 5763493 32.33 µM -0.594224045813523 0.295910497365153 no 2380 0.276181135993016 3471 1365576 YLR208W SEC13 SGTC_3290 9121031 71.43 µM -0.595144634141082 0.295627459721715 no 2381 0.275873397718396 3443 17014854 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.59532430883032 0.295572232717027 no 2382 0.275813354935182 3484 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1412 3909-8563 178 µM -0.595451421327778 0.29553316473406 no 2383 0.275770880999381 3573 23767530 SGTC_180 1486-1293 102.781 µM -0.596741026103745 0.295136939461453 no 2384 0.275340148544356 3575 4140536 SGTC_1887 st057648 70.8 µM -0.602561041557146 0.293351816509654 no 2385 0.273400371969754 3529 688672 SGTC_654 1124-0271 80.9 µM -0.602929362968174 0.293239013004031 no 2386 0.273277840666968 3488 5403748 SGTC_948 3448-0295 75.3 µM -0.605796226366634 0.292361684777284 no 2387 0.272325037945594 3547 678569 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.60631698735432 0.292202450643006 no 2388 0.272152140203438 3524 91467 include heat shock SGTC_2191 5911152 200 µM -0.606651286897983 0.292100252469383 no 2389 0.272041178249201 3481 2875902 SGTC_3279 9140807 49.47 µM -0.606878450059796 0.292030816280545 no 2390 0.271965790242773 3543 45595718 SGTC_2570 licareol 100 µM -0.608249829317362 0.291611794770904 no 2391 0.271510895255473 3474 443158 SGTC_1571 st070080 73.4 µM -0.608547747878935 0.291520803572421 no 2392 0.271412123954426 3577 4315245 SGTC_1710 st031758 61.5 µM -0.608751564305969 0.291458560964705 no 2393 0.271344561394321 3575 5394341 SGTC_299 1273-0059 1.44 µM -0.609493970874301 0.291231893099362 no 2394 0.271098533921405 3525 2848077 SGTC_47 0149-0135 24.25 µM -0.610111933232965 0.291043282699815 no 2395 0.270893831118785 3444 5239155 SGTC_1025 k007-0731 70 µM -0.610338969374248 0.290974002560435 no 2396 0.270818643758746 3466 6256118 SGTC_2125 5246583 200 µM -0.610794595457446 0.290834991392981 no 2397 0.270667785902572 3597 835267 SGTC_1431 4049-0260 9.09 µM -0.612820519440469 0.290217259788789 no 2398 0.269997510766127 3526 3854841 SGTC_4 0960-0234 25.671 µM -0.613477835044856 0.290016967526844 no 2399 0.269780217092368 3536 6821112 SGTC_2461 5755302 26.15 µM -0.618056830615957 0.28862349183669 no 2400 0.268268938735257 3567 2788904 SGTC_2100 5377183 190 µM -0.618075888438119 0.288617698774149 no 2401 0.268262657692041 3566 2844202 SGTC_1716 st033144 30.6155 µM -0.61870929509244 0.288425191450084 no 2402 0.268053942752055 3583 674617 SGTC_2417 cerulenin 830 nM -0.618849175834467 0.28838268653114 no 2403 0.26800786142513 3611 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_591 4299-0174 154 µM -0.619212112161276 0.288272416508725 no 2404 0.267888316839302 3472 5509088 SGTC_3009 9080819 71.4286 µM -0.619740364091867 0.288111954610258 no 2405 0.267714368324062 3518 17027216 SGTC_412 gemfibrozil 100 µM -0.621606391978469 0.287545467318993 no 2406 0.26710035846668 3542 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2118 5526350 200 µM -0.62187668826299 0.287463454667497 no 2407 0.267011477421831 3529 743594 SGTC_1686 st019653 115.5 µM -0.622052455939879 0.287410129596089 no 2408 0.266953688065806 3570 97252 SGTC_2833 9001315 45.46 µM -0.62295189884924 0.287137326417711 no 2409 0.266658065788929 3463 2989378 SGTC_3352 9151559 45.5865 µM -0.623083095000865 0.287097544559452 no 2410 0.266614959038404 3496 17159339 SGTC_1418 3966-3099 2.4 µM -0.625021186202507 0.286510172512481 no 2411 0.265978576609996 3565 740335 SGTC_3134 9127454 49.47 µM -0.625533698778355 0.286354942088695 no 2412 0.265810419155598 3645 24262820 SGTC_896 0964-0007 44.5 µM -0.626021974337095 0.286207089747975 no 2413 0.265650264102727 3553 6756758 SGTC_2347 9049783 174.81 µM -0.627897544328795 0.285639494916315 no 2414 0.265035529892618 3566 6467988 YPL169C MEX67 SGTC_1747 st037496 66.6 µM -0.62797536014799 0.285615957461656 no 2415 0.265010040710928 3550 723305 SGTC_732 3970-1727 52.7 µM -0.629238441283083 0.285234034271914 no 2416 0.264596482835661 3561 1275699 SGTC_2271 7849410 118.62 µM -0.630504566719324 0.284851434960008 no 2417 0.264182257941361 3560 972430 SGTC_2277 7947813 106.88 µM -0.631121064776557 0.284665229510481 no 2418 0.263980684412098 3629 1246798 SGTC_2255 7941087 197.44 µM -0.631580122577096 0.284526614656588 no 2419 0.263830639328737 3606 935561 SGTC_2027 5150920 200 µM -0.63165294177476 0.284504629489761 no 2420 0.26380684204681 3532 786715 SGTC_1331 1472-0049 76.2 µM -0.632737320779234 0.284177335864495 no 2421 0.263452597015903 3533 24051409 SGTC_2618 avocadyne 43.43 µM -0.633876835962698 0.283833594840342 no 2422 0.263080601916736 3519 3015189 SGTC_433 pimozide 108 µM -0.634064597702241 0.283776974585284 no 2423 0.263019332803889 3493 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_161 4065-0411 162.148 µM -0.634491484908118 0.283648265280193 no 2424 0.262880061066648 3541 1906281 YLR208W SEC13 SGTC_856 0433-0016 11.3 µM -0.635288723517257 0.28340796749195 no 2425 0.262620063376515 3567 3911780 SGTC_1079 idarubicin 2.36 µM -0.637378385130442 0.282778580642136 no 2426 0.261939202095379 3560 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_474 dl-dihydrosphingosine 5 µM -0.638645536157244 0.282397253737002 no 2427 0.261526775528724 3618 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2289 7946404 165.07 µM -0.63871605413915 0.282376039853109 no 2428 0.261503833452199 3611 1246120 YPR165W RHO1 SGTC_2713 st079149 53.4 µM -0.642957209576471 0.281101587068015 no 2429 0.260125932941484 3578 3103253 SGTC_2470 5664817 21.68 µM -0.64327907229287 0.281004981964904 no 2430 0.260021516609409 3610 2859561 SGTC_135 0933-0004 26.348 µM -0.64337878249922 0.280975057818404 no 2431 0.259989173743947 3559 21230617 YGL099W LSG1 SGTC_3040 9091894 49.47 µM -0.643567978432322 0.280918282239495 no 2432 0.259927810217221 3518 25236966 SGTC_473 2-arachidonoylglycerol 10 µM -0.643785473943586 0.280853021126557 no 2433 0.259857277278672 3510 5282280 An endocannabinoid. SGTC_527 4476-4215 268 µM -0.644799104342365 0.280548970656967 no 2434 0.259528691218019 3537 4418754 SGTC_851 0394-0702 453 µM -0.647816902479223 0.27964469055318 no 2435 0.258551690898681 3603 762646 SGTC_1911 st060208 74.3 µM -0.650664147493792 0.278792815626478 no 2436 0.257631655831389 3594 688783 SGTC_2959 9079155 11 µM -0.650707923250237 0.278779728104545 no 2437 0.257617523778574 3593 16189457 SGTC_3055 9094636 49.47 µM -0.651117438445373 0.278657310916957 no 2438 0.257485340185496 3638 25236176 SGTC_1800 st050079 29.0735 µM -0.651836334967471 0.278442473083751 no 2439 0.257253379519166 3574 3645560 SGTC_903 1134-0042 114 µM -0.652576942834753 0.278221231381181 no 2440 0.257014527069702 3578 701009 SGTC_740 k014-0057 261 µM -0.653120413026981 0.278058935141077 no 2441 0.256839326641505 3584 4012779 SGTC_3031 9088762 49.47 µM -0.653802230581154 0.277855389637886 no 2442 0.25661961461635 3576 205253 SGTC_744 1594-0068 283 µM -0.654405676276804 0.277675301472978 no 2443 0.256425239181266 3621 668392 SGTC_281 1672-3440 14.9 µM -0.657843569488646 0.27665040940445 no 2444 0.255319327250518 3608 6833000 SGTC_2555 cholic acid 100 µM -0.65975082354678 0.276082626479584 no 2445 0.254706872949747 3622 6708657 Influences liver metabolism. SGTC_2320 7373003 200 µM -0.661493775466326 0.275564256533843 no 2446 0.254147852561943 3611 5415828 SGTC_2 0422-0095 29 µM -0.662414830786459 0.275290519632594 no 2447 0.253852700762916 3513 6790840 SGTC_2414 st077232 92.9 µM -0.663058968323972 0.275099162036571 no 2448 0.253646394118118 3581 729801 SGTC_394 menadione 8.33 µM -0.663959590948385 0.274831718836923 no 2449 0.253358087230493 3585 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_543 3844-1095 191 µM -0.664555176562666 0.274654927925755 no 2450 0.253167523311741 3621 4230703 SGTC_2622 2-methoxyxanthone 59.94 µM -0.665022755267075 0.274516173312831 no 2451 0.253017969396729 3631 71034 A hepatoprotective. SGTC_260 nsc-65238 3.989 µM -0.665299423543302 0.274434087918168 no 2452 0.252929499613845 3566 3246252 SGTC_103 0844-0104 51.839 µM -0.665400523470103 0.274404095353406 no 2453 0.252897175110021 3659 5375804 SGTC_2762 leflunomide 42.06 µM -0.666931373955997 0.273950147127043 no 2454 0.252407984793083 3617 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1760 st045453 10.4495 µM -0.671451316928338 0.272612003108399 no 2455 0.25096653148644 3648 3323419 YIL048W NEO1 SGTC_2396 5342950 42.78 µM -0.671768593387494 0.272518194372185 no 2456 0.250865512851592 3629 1886677 SGTC_1119 parthenolide 318.541 nM -0.671811557687769 0.272505492403213 no 2457 0.250851834969825 3701 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_666 0272-0154 136 µM -0.672387370608229 0.272335287403848 no 2458 0.250668560396061 3652 6870312 SGTC_1722 st034304 3.6505 µM -0.673253144703808 0.272079471993946 no 2459 0.250393128081821 3649 4036148 YLR033W RSC58 SGTC_2349 9023730 187.07 µM -0.673789377945333 0.271921087913921 no 2460 0.250222614451964 3627 4126287 SGTC_735 3076-0345 636 µM -0.676360888351856 0.271162193825106 no 2461 0.249405771532603 3666 2888990 SGTC_3265 9137266 49.47 µM -0.677574418070334 0.27080442882073 no 2462 0.249020785387628 3588 17224265 SGTC_2644 guaiazulene 100 µM -0.678141253458708 0.270637398838009 no 2463 0.248841068138428 3652 3515 A coloring agent. SGTC_79 0052-0007 94.094 µM -0.678349336459938 0.270576095713654 no 2464 0.248775111985595 3678 2801472 SGTC_359 0081-0058 15.9 µM -0.679341717713819 0.270283826725149 no 2465 0.24846068459348 3726 3494159 SGTC_1780 st038448 24.544 µM -0.681100832231523 0.269766133153557 no 2466 0.247903845257778 3677 728868 YDL195W SEC31 SGTC_65 0798-0905 34.986 µM -0.682337802016024 0.269402400255776 no 2467 0.247512687572963 3756 3602145 SGTC_463 ikarugamyin 104 µM -0.682803397959935 0.269265554759093 no 2468 0.247365541125098 3693 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2853 9015042 58.44 µM -0.683769395974415 0.268981744981461 no 2469 0.24706039734529 3596 6457456 SGTC_154 3389-1638 511.116 µM -0.684541433448846 0.268755028736579 no 2470 0.24681666754674 3571 5238686 SGTC_858 0438-0351 2.77 µM -0.684957848017186 0.268632784448486 no 2471 0.246685260234889 3664 2799119 SGTC_678 1218-2179 85.9 µM -0.687184241234255 0.267979670184934 no 2472 0.245983316829302 3651 6820081 YOR116C RPO31 SGTC_2479 5617353 43.85 µM -0.687668890970058 0.267837603830868 no 2473 0.245830657282826 3687 2731746 SGTC_1282 0886-0010 32.4 µM -0.687845037532336 0.267785979035986 no 2474 0.245775185579881 3715 2836211 YNL267W PIK1 SGTC_826 1683-5028 118 µM -0.68847957499927 0.26760005122577 no 2475 0.245575414099931 3687 722377 SGTC_430 0958-0115 16.4 µM -0.688753736442612 0.267519738460455 no 2476 0.24548912682307 3637 6833180 SGTC_1113 artemisinin 1.17947 µM -0.689362449121938 0.267341465823267 no 2477 0.245297603939768 3678 2240 An anti-malaria and mitochondrial poison. SGTC_408 cantharidin 100 µM -0.691832263099983 0.266618751122217 no 2478 0.244521336504439 3650 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1477 0139-0234 16 µM -0.696554903033418 0.265239572402941 no 2479 0.243040693329382 3682 620880 SGTC_2295 7971645 200 µM -0.696676795530273 0.265204023472503 no 2480 0.243002541865502 3676 2978226 YKL099C UTP11 SGTC_1959 st077091 55.8 µM -0.697284953119386 0.265026695536662 no 2481 0.242812241379098 3685 821356 YKL052C ASK1 SGTC_1970 st070122 35.8 µM -0.697867528795898 0.264856883341386 no 2482 0.242630021470384 3694 102928 SGTC_283 0987-0079 11.7 µM -0.698236994765116 0.264749218141535 no 2483 0.242514497086865 3696 411556 SGTC_1620 st003704 16.5 µM -0.699597604210638 0.264352918148543 no 2484 0.242089319585655 3653 2834414 SGTC_1112 tnp00069 1.16933 µM -0.701257305488347 0.263869911917411 no 2485 0.241571226457313 3724 145826 SGTC_1834 st055981 52.8 µM -0.702070824998617 0.263633325908229 no 2486 0.241317497872476 3708 471719 YDL150W RPC53 SGTC_925 2064-1272 59.6 µM -0.702740479513625 0.263438659647671 no 2487 0.24110874804499 3670 6815817 SGTC_2955 9076254 12.21 µM -0.702814430714823 0.263417166788032 no 2488 0.241085701431848 3617 16459619 SGTC_663 1486-0733 13.9 µM -0.703158335702409 0.263317227481407 no 2489 0.240978540476782 3684 722445 YPR165W RHO1 SGTC_871 0574-0004 149 µM -0.705131434956793 0.262744216329124 no 2490 0.240364222798105 3664 9551173 SGTC_3338 9144300 39.5675 µM -0.70832531102746 0.261818031067565 no 2491 0.239371631213674 3696 4901274 SGTC_2994 9053520 71.4286 µM -0.70915557946037 0.261577537851835 no 2492 0.23911396783356 3681 4647384 SGTC_2520 obtusaquinone 4.71 µM -0.709649616656673 0.261434490257197 no 2493 0.238960721561416 3730 5967872 SGTC_2375 9072683 200 µM -0.709988108271111 0.261336503805813 no 2494 0.238855755258399 3736 16798029 SGTC_1786 berberine 21.6 µM -0.710772568814975 0.261109490943309 no 2495 0.238612590892471 3668 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_553 k007-0256 45.7 µM -0.71112197743288 0.261008409189916 no 2496 0.238504326045281 3728 6287000 SGTC_1180 1193-0155 285 µM -0.712169501552327 0.26070548755921 no 2497 0.238179910159032 3682 2921347 SGTC_2377 9073351 62.6 µM -0.712746394535628 0.260538739702444 no 2498 0.23800135098124 3674 7337946 YHR072W ERG7 SGTC_2528 xanthyletin 44.79 µM -0.713094259014699 0.260438217865569 no 2499 0.237893715887546 3742 65188 An natural product with antifungal activity of unknown mechanism. SGTC_944 3370-0224 231 µM -0.713110650453732 0.260433481750717 no 2500 0.237888644760451 3721 4580514 SGTC_2534 helenine 20.12 µM -0.713693851455153 0.260265001503662 no 2501 0.237708254616483 3709 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1402 3909-7673 35.9 µM -0.715386084360767 0.259776452448176 no 2502 0.237185254384674 3700 5328014 SGTC_2735 sertaconazole 140 nM -0.715711555130448 0.259682543054967 no 2503 0.237084737163856 3757 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2326 6164455 177.58 µM -0.715886274547782 0.259632137786284 no 2504 0.237030787105108 3693 2888790 SGTC_1238 0333-0287 48.8 µM -0.717737106815839 0.259098496579311 no 2505 0.236459699518794 3709 7226 SGTC_2782 7736369 71.43 µM -0.721058911733296 0.258142161456535 no 2506 0.235436634765785 3764 2950836 YOL077C BRX1 SGTC_1381 2324-0066 62.1 µM -0.72375659363432 0.25736685785121 no 2507 0.234607590981693 3738 10885928 SGTC_2975 9084847 53.72 µM -0.726314200910789 0.256632930154091 no 2508 0.233823087808798 3769 27211724 SGTC_318 1488-0629 67.2 µM -0.72660356525735 0.256549963216709 no 2509 0.233734421780578 3754 3662576 SGTC_680 0417-1641 114 µM -0.727155501610114 0.256391750026062 no 2510 0.233565351030064 3709 2835990 SGTC_3340 9146634 11.102 µM -0.72759228507086 0.256266581593353 no 2511 0.233431602334649 3735 4907387 SGTC_3140 9094243 49.47 µM -0.732742404970349 0.254793124483523 no 2512 0.231857777635679 3745 19291112 SGTC_3249 9135183 49.47 µM -0.733566146652455 0.254557862837841 no 2513 0.231606599888194 3739 4902779 SGTC_783 0848-0141 92.7 µM -0.733588947581051 0.254551352483264 no 2514 0.231599649519407 3712 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.734074695528417 0.254412677481745 no 2515 0.231451607410396 3674 756377 SGTC_1274 0865-0114 173 µM -0.734445711885916 0.254306783598831 no 2516 0.231338567765981 3749 870624 SGTC_1613 st002381 52.1 µM -0.736127162182999 0.253827161134072 no 2517 0.230826657006221 3709 551167 SGTC_2401 5128683 200 µM -0.736349392634568 0.253763806927998 no 2518 0.230759047203793 3702 708373 SGTC_802 4112-3352 742 µM -0.738172131882626 0.253244487758333 no 2519 0.230204927675927 3823 704594 SGTC_1109 tnp00067 928.257 nM -0.74005248801829 0.252709339055507 no 2520 0.229634073171778 3737 676295 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.745138336679772 0.251264897309239 no 2521 0.228094047754824 3747 616764 SGTC_627 1391-0720 175 µM -0.745387569689907 0.251194224537691 no 2522 0.228018728088511 3744 997839 SGTC_869 0564-0080 44.1 µM -0.745695675183922 0.251106872356442 no 2523 0.227925636154092 3777 6843321 SGTC_1396 3511-0007 98.6 µM -0.745701654796846 0.251105177212207 no 2524 0.227923829667129 3720 X1396 SGTC_1270 0831-1170 17.3 µM -0.746622819890627 0.250844110932869 no 2525 0.227645634840342 3733 6764716 SGTC_2355 9061122 103.12 µM -0.747299391077661 0.250652456277372 no 2526 0.227441429985105 3769 5302957 SGTC_203 k066-0004 30.888 µM -0.747475287041948 0.250602642326665 no 2527 0.227388357413252 3817 6795412 SGTC_2179 6298986 200 µM -0.747922935330306 0.250475891448264 no 2528 0.22725332128813 3688 738374 SGTC_1572 epiandrosterone 68.9 µM -0.748266637491918 0.250378595805812 no 2529 0.22714967188991 3687 441302 A steroid. SGTC_1251 0490-5699 265 µM -0.748664590667958 0.250265967748712 no 2530 0.227029695445566 3763 3883818 SGTC_2288 7946289 167.31 µM -0.749435091615557 0.25004797821215 no 2531 0.226797503470485 3757 1246052 SGTC_3347 9188721 44.724 µM -0.750341320957505 0.249791717482241 no 2532 0.226524581016998 3782 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1971 st069429 63.5 µM -0.751169562752002 0.249557631842454 no 2533 0.226275307757689 3765 1246522 YGL099W LSG1 SGTC_216 k038-0035 28.382 µM -0.752502360678936 0.249181188517365 no 2534 0.225874505375257 3673 4444231 YPR107C YTH1 SGTC_2242 6630449 61.2675 µM -0.752534344573231 0.249172158509297 no 2535 0.225864892032499 3835 691249 YDR170C SEC7 SGTC_2224 6650123 117.647 µM -0.75316500902285 0.248994138666021 no 2536 0.22567538159783 3722 2908370 SGTC_3315 9136395 68.55 µM -0.754569210350484 0.248598013108575 no 2537 0.225253751834086 3782 16876844 SGTC_1470 k295-0292 231 µM -0.754946476516308 0.248491643467975 no 2538 0.225140548829056 3818 5045612 SGTC_352 k048-0007 5.11 µM -0.755914978286023 0.248218686900239 no 2539 0.224850086477772 3779 6811911 SGTC_2159 5658611 73.75 µM -0.756136113712555 0.248156385883731 no 2540 0.224783795788343 3751 793844 SGTC_3102 9121669 49.47 µM -0.756239905150724 0.248127147347934 no 2541 0.224752685617664 3781 41905072 SGTC_3083 9117465 49.47 µM -0.756313734465303 0.248106350401607 no 2542 0.224730557700711 3727 16420915 SGTC_1728 st035614 33.7865 µM -0.756421160327429 0.248076091319812 no 2543 0.224698362526765 3780 15945546 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.758124880031646 0.247596460940595 no 2544 0.224188113240604 3765 641818 YHR062C RPP1 SGTC_2381 9035592 200 µM -0.75930335384611 0.247264987588647 no 2545 0.223835555860526 3787 4749657 SGTC_2187 6125751 200 µM -0.760134196796729 0.247031436238349 no 2546 0.223587186763449 3786 874498 SGTC_370 0180-0345 38.7 µM -0.760224952647388 0.247005931768181 no 2547 0.223560066046066 3699 3989527 SGTC_2564 betulinic acid 100 µM -0.760747464312004 0.246859121447124 no 2548 0.223403959441953 3769 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1424 4048-1941 275 µM -0.761258869954682 0.246715476829645 no 2549 0.223251230970465 3846 X1424 SGTC_379 3970-0972 5.9 µM -0.761544754417392 0.246635196550288 no 2550 0.223165879057836 3776 2898042 YBL034C STU1 SGTC_514 4466-0038 2.65 nM -0.761611935574602 0.246616333190092 no 2551 0.223145824559421 3704 5722064 SGTC_3100 9120536 49.47 µM -0.761724153321236 0.246584826022385 no 2552 0.223112328308765 3638 16421196 SGTC_1646 st011709 75.6 µM -0.762884455641778 0.246259176546929 no 2553 0.22276615366853 3716 5757843 SGTC_754 3474-0146 171 µM -0.763429073916883 0.246106403990022 no 2554 0.222603773147778 3740 24762078 SGTC_3264 9137442 49.47 µM -0.767062344734894 0.245088526020652 no 2555 0.221522224404556 3772 17015726 SGTC_1977 st070720 65.3 µM -0.768608473569868 0.244656058536378 no 2556 0.221062886838307 3815 682188 SGTC_316 k060-0003 58.6 µM -0.769458292687701 0.244418530867146 no 2557 0.220810647395411 3761 6152314 SGTC_2843 9000894 45.46 µM -0.769483087931514 0.244411602368551 no 2558 0.220803290259252 3705 2242070 SGTC_1974 st069448 26.9 µM -0.769494917401719 0.24440829691434 no 2559 0.220799780320116 3764 6323587 YNR016C ACC1 SGTC_3190 9110366 49.47 µM -0.769810123500429 0.244320229203437 no 2560 0.220706266833246 3720 17123768 SGTC_214 4373-3496 70 µM -0.77041755248391 0.244150563478509 no 2561 0.220526122376309 3862 3779166 SGTC_1587 estradiol valerate 56.1 µM -0.77067129183505 0.244079708379878 no 2562 0.220450896168678 3778 13791 A steroid. SGTC_2245 6637752 200 µM -0.771971923927148 0.243716689331474 no 2563 0.220065528224592 3840 681890 SGTC_549 1661-1316 519 µM -0.774648372858555 0.242970584413445 no 2564 0.219273732667668 3803 2857282 SGTC_685 1278-0033 54.9 µM -0.776423186851507 0.242476507488021 no 2565 0.218749579238465 3826 3590572 SGTC_2336 9001819 198.65 µM -0.776734295742569 0.242389956351961 no 2566 0.218657774200363 3815 2989602 SGTC_3254 9136651 49.47 µM -0.777715924832703 0.242116974874657 no 2567 0.218368250968144 3798 16454030 SGTC_2928 9011484 9.79 µM -0.778845825122861 0.241802967095675 no 2568 0.218035269927067 3822 2994751 SGTC_715 0868-0130 184 µM -0.779783773888273 0.241542472049249 no 2569 0.217759079384136 3819 2876258 SGTC_1129 3453-1384 223 µM -0.780262913896561 0.24140946007427 no 2570 0.217618068637871 3947 1084452 SGTC_3204 9114183 49.47 µM -0.781790339426326 0.240985703841206 no 2571 0.217168899700288 3831 17027248 SGTC_2514 salinomycin 42.74 µM -0.782740525469818 0.240722296369903 no 2572 0.216889749594849 3897 23682228 A polyether potassium ionophore. SGTC_7 0192-1582 4.227 µM -0.784140921712307 0.240334368912782 no 2573 0.216478712996565 3851 252616 SGTC_3331 9141060 1.957 µM -0.784986856221436 0.240100199469193 no 2574 0.216230637492518 3793 4906567 YPR165W RHO1 SGTC_2299 7976368 114.88 µM -0.787226205495955 0.239480909357637 no 2575 0.215574729680742 3865 2979718 SGTC_1433 4060-0023 7.6 µM -0.787361098003538 0.239443632823089 no 2576 0.215535256398638 3815 3840627 SGTC_1219 1469-0211 33.1 µM -0.787918861810734 0.239289532613682 no 2577 0.215372083775011 3795 6822282 SGTC_811 0416-0114 265 µM -0.790460494238135 0.238588011271766 no 2578 0.214629442566169 3864 6612453 SGTC_162 k030-0015 37.8 µM -0.792112768735395 0.238132567922163 no 2579 0.214147462740108 3883 1809920 YMR134W ERG29 SGTC_1914 st062367 72.6 µM -0.793153138182141 0.237846038547757 no 2580 0.213844303225788 3840 978205 SGTC_2996 9066192 71.4286 µM -0.793177558367812 0.237839315227452 no 2581 0.213837190284057 3876 6472854 SGTC_223 busulfan 5 mM -0.794504107283712 0.237474248887908 no 2582 0.213451009406444 3827 2478 A DNA alkylator. SGTC_1372 2752-0194 270 µM -0.796123044425197 0.237029134368617 no 2583 0.212980260562339 3791 823334 SGTC_186 3455-3465 67.277 µM -0.79758296473179 0.236628133816972 no 2584 0.212556269995225 3776 755278 SGTC_1801 st050089 28.441 µM -0.799034907011795 0.236229695066617 no 2585 0.212135085782069 3855 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_595 3909-8003 73.7 µM -0.799824537288964 0.236013161700892 no 2586 0.211906232216027 3915 699517 SGTC_694 1315-0438 43.2 µM -0.802194763623871 0.235363852723449 no 2587 0.211220152460704 3794 6793154 SGTC_2616 abietic acid 100 µM -0.802847053692229 0.235185335027041 no 2588 0.211031570840956 3832 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_669 0108-0021 26.2 µM -0.803148332772181 0.235102906703644 no 2589 0.210944502283168 3821 17201 SGTC_1929 genistein trimethyl ether 50.5 µM -0.804169520905131 0.234823633907965 no 2590 0.21064953935516 3786 136420 SGTC_2682 pyrogallin 40.03 µM -0.80545835059672 0.234471428862234 no 2591 0.210277615710621 3861 822798 An ATP competetive kinase inhibitor. SGTC_3305 9127027 53.8275 µM -0.807414013906786 0.233937553453746 no 2592 0.209713997857217 3774 41905295 SGTC_3165 9101544 49.47 µM -0.80881829221425 0.233554616114794 no 2593 0.209309836430393 3861 5002184 SGTC_1569 carminic acid 40.6 µM -0.808836560173984 0.233549636855442 no 2594 0.209304581802166 3900 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2748 diazoxide 86.69 µM -0.810000662695477 0.233232461313188 no 2595 0.208969897433585 3842 3019 A potassium channel activatior. SGTC_442 cape 100 µM -0.810003377752516 0.233231721838581 no 2596 0.208969117211915 3786 5281787 SGTC_2421 5690543 90.72 µM -0.811405204947126 0.232850093154137 no 2597 0.208566505534262 3896 3397993 SGTC_2834 9001755 58.44 µM -0.811515390527264 0.232820111318514 no 2598 0.208534879090592 3798 2989575 SGTC_587 k089-0003 57 µM -0.811950533994419 0.232701728405617 no 2599 0.208410007985084 3755 9659696 SGTC_743 1275-0778 158 µM -0.815490977804609 0.2317397777876 no 2600 0.207395663429918 3853 2849257 YMR203W TOM40 SGTC_1945 st075991 56.6 µM -0.81564452779171 0.231698107923362 no 2601 0.207351737172961 3869 1084980 SGTC_1148 3909-7663 27.7 µM -0.816045146500395 0.231589409063732 no 2602 0.207237157525841 3915 4084526 SGTC_3308 9128332 17.569 µM -0.816084576059623 0.231578712277912 no 2603 0.207225882430885 3870 17332805 YDL196W YDL196W SGTC_109 0132-0036 33.701 µM -0.816242942803887 0.231535751976501 no 2604 0.207180600261878 3673 67274 A color developer. SGTC_1741 st038134 10.228 µM -0.817418974916682 0.231216867627275 no 2605 0.206844517825973 3914 1272587 SGTC_642 0335-0876 158 µM -0.817894560327917 0.231087980945032 no 2606 0.206708698344931 3878 6812350 SGTC_1726 st035556 14.5795 µM -0.819973815432324 0.230524960651424 no 2607 0.206115517219758 3996 5919439 SGTC_1269 0831-0796 3.05 µM -0.820937634104472 0.23026423829946 no 2608 0.205840896530575 3889 927758 SGTC_3226 9131256 49.47 µM -0.821212765760272 0.230189842771626 no 2609 0.205762543162514 3742 17178073 SGTC_1363 1636-0063 10.4 µM -0.821405736243586 0.230137671626512 no 2610 0.205707598625175 3861 6072185 SGTC_27 0485-0001 32.618 µM -0.822462676338641 0.229852036617241 no 2611 0.205406810281055 3795 2054479 SGTC_1501 4491-0275 38.4 µM -0.822830016556657 0.229752810480991 no 2612 0.205302332293635 3806 5104718 SGTC_3050 9093513 49.47 µM -0.827104267948117 0.228600012380035 no 2613 0.204088982687321 3861 25236664 SGTC_1885 st057546 99.9 µM -0.828052230419122 0.228344780546137 no 2614 0.203820460514828 3935 702008 SGTC_698 k064-0052 127 µM -0.828305386358093 0.228276647300183 no 2615 0.203748786586843 3921 5088751 SGTC_3285 9112818 20.8695 µM -0.828706709473025 0.22816866042972 no 2616 0.203635194118451 3860 17017947 YPR165W RHO1 SGTC_2831 7999036 19.48 µM -0.82920080712118 0.228035749511561 no 2617 0.203495394169744 3949 2988270 SGTC_1968 st069590 43.6 µM -0.829287625102144 0.228012400210412 no 2618 0.203470835811952 3873 6384066 SGTC_2819 7996655 46.38 µM -0.829839013487913 0.227864138207098 no 2619 0.203314904867155 3830 6456960 SGTC_2814 7977482 42.97 µM -0.834634866615005 0.226576878509992 no 2620 0.20196166228838 3964 6456762 SGTC_551 k048-0028 34.9 µM -0.836284762153684 0.226134979284525 no 2621 0.201497361711817 3872 6836383 SGTC_747 3448-8087 38.7 µM -0.83648779055162 0.226080634915733 no 2622 0.201440271291905 3919 5168703 SGTC_1206 3978-0017 132 µM -0.838295874681045 0.225596992898418 no 2623 0.200932276113064 3992 3873677 SGTC_526 4469-0568 170 µM -0.838692704934607 0.225490923706521 no 2624 0.200820886537756 3842 2901964 SGTC_1611 st001856 99.4 µM -0.83882240184439 0.225456262999484 no 2625 0.20078448887309 3871 647478 SGTC_1401 3807-4679 7.6 µM -0.838977208969453 0.225414895689403 no 2626 0.200741049553496 3829 3291456 SGTC_3148 9097893 49.47 µM -0.839145046568946 0.225370051252261 no 2627 0.200693960219518 3908 17174100 SGTC_1590 st077108 57.8 µM -0.840055476784263 0.225126881933932 no 2628 0.200438641049717 3878 5489485 SGTC_910 3454-3003 490 µM -0.841488143979432 0.224744528069548 no 2629 0.200037262104912 3819 820824 SGTC_2828 7998861 71.43 µM -0.843266219431457 0.224270503317095 no 2630 0.199539785454305 3809 2988188 SGTC_3232 9132874 49.47 µM -0.843323496203548 0.224255243100097 no 2631 0.199523772732389 3864 3784940 SGTC_1675 st018485 24.5 µM -0.843414007528854 0.224231129422439 no 2632 0.199498470287544 3950 3323024 SGTC_418 lividomycin a 100 µM -0.84366937549401 0.224163103212939 no 2633 0.199427092574455 3856 72394 An antibiotic. SGTC_1725 st036284 20.55 µM -0.845209295788232 0.22375313997505 no 2634 0.19899699655719 4001 707914 SGTC_813 k007-0158 173 µM -0.846783996301034 0.223334358548128 no 2635 0.198557765035885 3905 6523916 SGTC_701 4424-0219 185 µM -0.848203515172879 0.222957229246096 no 2636 0.198162319969606 3933 2911779 SGTC_544 k015-0020 52.4 µM -0.849648981501544 0.222573579398569 no 2637 0.1977601355164 3911 3008304 SGTC_59 0330-0160 1.33 µM -0.849875604455999 0.222513464196762 no 2638 0.197697125031985 3868 4293482 SGTC_1343 1487-0095 224 µM -0.851551818535158 0.222069110395816 no 2639 0.197231445578179 3884 4560101 YGL055W OLE1 SGTC_100 0086-0128 49.5915 µM -0.851871531642994 0.221984414022891 no 2640 0.197142699509346 3961 93297 SGTC_1905 st060207 84.5 µM -0.852139161345797 0.221913529439861 no 2641 0.197068429351286 3826 1948547 SGTC_1085 doxorubicin 7.67 µM -0.853029621359201 0.221677774676105 no 2642 0.196821438923056 3914 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2741 miltefosine 3.04 µM -0.856899652137858 0.220654824358084 no 2643 0.195750172529505 3862 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_912 3474-0017 2.18 µM -0.857972904644413 0.220371615325483 no 2644 0.195453712615825 3963 3360550 SGTC_2083 5306046 65.942 µM -0.859064463089053 0.220083789581368 no 2645 0.195152476014082 3935 539837 SGTC_253 dyclonine 31.25 µM -0.859214620255921 0.220044212521947 no 2646 0.195111059337521 3995 3180 An oral anasthetic. SGTC_2235 salicylic acid 500 µM -0.863031609481422 0.21903953716004 no 2647 0.194060043930265 3926 338 A COX inhibitor and kinase inhibitor. SGTC_637 1181-0519 7.26 µM -0.864136288514971 0.218749265928018 no 2648 0.193756513175275 3941 6252091 YGR060W ERG25 SGTC_101 0490-5701 117.494 µM -0.864241570519674 0.218721613037804 no 2649 0.193727600134745 3742 4661669 SGTC_3013 9080133 71.4286 µM -0.864403411924884 0.218679108437609 no 2650 0.193683159615111 4005 17050193 SGTC_3063 1327-0034 4 µM -0.865009854981534 0.218519879870703 no 2651 0.193516689880718 3828 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2329 6138490 200 µM -0.865285681782983 0.218447480479456 no 2652 0.193441003799704 4058 720019 SGTC_2915 7971052 15.16 µM -0.867369521541306 0.217900958014878 no 2653 0.192869787941573 3791 5741558 SGTC_2458 5808907 16.39 µM -0.868490896339258 0.217607185000155 no 2654 0.192562826930496 4049 2731747 SGTC_792 4534-1957 155 µM -0.869065499362492 0.217456741544427 no 2655 0.19240565299007 3881 1717904 SGTC_3010 9080089 71.4286 µM -0.869072092595433 0.217455015642451 no 2656 0.192403849966545 3934 17027233 SGTC_2004 4023728 41.89 µM -0.871278830070492 0.216877805252003 no 2657 0.191800963318566 3943 360084 YDR527W RBA50 SGTC_953 1188-0045 9.7 µM -0.871855217900213 0.216727187052219 no 2658 0.191643683315731 3976 6144426 SGTC_3125 9127534 49.47 µM -0.87208239008209 0.216667840407761 no 2659 0.191581716134548 3806 1639235 SGTC_972 1319-0219 195 µM -0.873443238697319 0.216312528070765 no 2660 0.191210765961461 3910 23903702 SGTC_1058 3448-5425 97.3 µM -0.873779995235042 0.216224654324777 no 2661 0.191119038384314 3808 7279705 SGTC_2693 st077581 40.7 µM -0.876396426205162 0.215542623471766 no 2662 0.190407280250036 3997 25238761 SGTC_695 3505-6186 243 µM -0.876883201909656 0.215415872365105 no 2663 0.190275040543546 3949 1819379 SGTC_2817 7995342 71.43 µM -0.877888218871702 0.215154313708123 no 2664 0.190002191602451 3952 18879975 SGTC_2729 fluphenazine 10.66 µM -0.879133748903264 0.214830416759985 no 2665 0.189664380414422 3881 3372 An atypical antipsychotic. SGTC_866 0495-0101 262 µM -0.879218795252568 0.214808311007067 no 2666 0.189641327725888 3891 635694 SGTC_2716 st080858 38.6235 µM -0.879622592346764 0.214703371699063 no 2667 0.189531897887714 3921 5296050 SGTC_2848 9016370 25.97 µM -0.880761305428798 0.2144076019913 no 2668 0.189223513644142 3909 7894410 SGTC_1678 st019265 80.2 µM -0.881093793277958 0.214321286201145 no 2669 0.189133528183604 3960 5367020 SGTC_179 1273-0063 6.77 µM -0.882674655644763 0.213911161686373 no 2670 0.188706039708209 3931 3108139 SGTC_3021 9087658 49.47 µM -0.883808409713547 0.213617312434741 no 2671 0.188399822940398 3896 25237042 SGTC_2655 perillic acid 100 µM -0.884152121370674 0.213528274854555 no 2672 0.18830705009241 3979 5702197 An apoptosis inducer. SGTC_566 0958-0068 16.5 µM -0.885301306722002 0.213230738557196 no 2673 0.187997072703522 3850 6815365 SGTC_3350 9150499 3.57 µM -0.8854800567501 0.213184480013472 no 2674 0.187948885597487 3918 4910996 YPR165W RHO1 SGTC_1808 st050063 61.5 µM -0.886018831376813 0.213045086470131 no 2675 0.187803689855534 3908 4011993 SGTC_1556 plumbagin 1.48 µM -0.886646795152463 0.212882684742812 no 2676 0.187634545754905 3856 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2740 felodipine 17.08 µM -0.887819336720133 0.212579639753918 no 2677 0.187318969878178 3938 3333 L-type calcium channel blocker SGTC_1698 5-fluorocytosine 1.055 µM -0.887860559323731 0.212568990301728 no 2678 0.187307881269712 3984 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1636 st007707 68.9 µM -0.887906702114487 0.212557070137431 no 2679 0.187295469644738 3987 403051 SGTC_837 0091-0265 12.5 µM -0.888073616016137 0.212513954178419 no 2680 0.187250576894111 3910 759367 SGTC_1552 6-methylflavone 10.6 µM -0.891346976907027 0.211669436934558 no 2681 0.186371526964001 3865 689013 SGTC_2257 7960413 200 µM -0.891955904646237 0.211512552389355 no 2682 0.186208283958232 3947 2974689 YIL048W NEO1 SGTC_1279 0874-0590 65.2 µM -0.892428637006394 0.211390804270398 no 2683 0.186081613697935 4015 3523074 SGTC_3094 9117742 49.47 µM -0.892687929721201 0.21132404311504 no 2684 0.186012158013292 3895 17149698 SGTC_3354 9151612 71.43 µM -0.892864915805055 0.211278480877667 no 2685 0.185964758701796 3986 27261949 SGTC_2024 5144227 134 µM -0.893350417016379 0.211153525903938 no 2686 0.185834773242109 4042 3475211 SGTC_220 paclitaxel 373.376 µM -0.895122201492118 0.210697883721783 no 2687 0.18536088351648 3916 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1316 1272-0050 65.9 µM -0.897834393097813 0.210001519489696 no 2688 0.1846369228698 3927 7340392 SGTC_575 k072-0246 11.9 µM -0.899512854545665 0.209571247187961 no 2689 0.184189775980932 3994 6796779 SGTC_2625 euphol 100 µM -0.900830480378194 0.209233838420062 no 2690 0.183839229355876 4011 6708538 A triterpene alcohol. SGTC_1411 3909-8223 150 µM -0.901122995740376 0.209158976450363 no 2691 0.183761463760821 3981 X1411 SGTC_1301 naphtanilide LB 4.81 µM -0.901217963221184 0.209134675297172 no 2692 0.183736220937866 4038 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2700 st077718 96.8 µM -0.905136913854134 0.208133308668901 no 2693 0.182696429109147 3966 904970 SGTC_1125 tnp00248 1.32998 µM -0.906699315771375 0.207734875446054 no 2694 0.182282912682371 4084 24207736 SGTC_1169 aniline yellow 25.8 µM -0.907297554854262 0.207582435905795 no 2695 0.182124733435869 3916 6051 A DNA damaging agent. SGTC_1405 3909-7894 12 µM -0.907737470476587 0.207470381547234 no 2696 0.182008470956449 3981 7104060 SGTC_2643 anethole 100 µM -0.907781854101312 0.207459078231939 no 2697 0.181996743670565 3981 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_438 sphingosine 6.67 µM -0.908193728058527 0.20735420237797 no 2698 0.181887938601432 3943 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_486 niguldipine 82 µM -0.909064477157516 0.207132585924842 no 2699 0.181658046077438 4027 1236 A calcium channel blocker. SGTC_1503 4585-0012 61.3 µM -0.909653822673309 0.206982669715761 no 2700 0.181502552091003 4047 2922052 SGTC_939 1165-0479 45.3 µM -0.911651017043696 0.206475106202928 no 2701 0.180976228516952 3965 1377347 SGTC_1130 3454-2858 15.9 µM -0.91170911488365 0.206460352364141 no 2702 0.180960932236663 4035 715628 YIL048W NEO1 SGTC_651 3253-0966 34.4 µM -0.9133178580965 0.206052063161112 no 2703 0.180537696399966 4006 781462 SGTC_1671 st016596 74.5 µM -0.913363867359961 0.206040393338079 no 2704 0.180525601202662 4031 2829167 SGTC_653 0203-0016 55.2 µM -0.913631922713552 0.205972411377525 no 2705 0.180455143274599 4030 295302 SGTC_1453 4237-0541 195 µM -0.916344808581261 0.205285140892997 no 2706 0.179743036542119 3975 739892 SGTC_1924 st058459 75.1 µM -0.917135856421524 0.205084997161555 no 2707 0.179535726908405 3950 688683 SGTC_2898 9056270 58.44 µM -0.917201289509201 0.205068447071533 no 2708 0.179518585614007 3923 19154699 SGTC_3068 9116768 49.47 µM -0.917360198105927 0.205028257384305 no 2709 0.179476961125558 3960 41904888 SGTC_181 1447-1644 8.07 µM -0.91952042088058 0.20448237846187 no 2710 0.178911714711528 4006 534600 SGTC_3236 9132701 49.47 µM -0.919991882802411 0.20436335717222 no 2711 0.178788500534826 3996 24282524 SGTC_2925 9010536 32.5 µM -0.920785177938827 0.204163181697089 no 2712 0.178581297476853 3956 2994177 SGTC_246 cycloheximide 667 µM -0.922581646388999 0.203710303193725 no 2713 0.178112631957811 3867 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1910 st062352 60.4 µM -0.923213932538675 0.203551050402481 no 2714 0.177947864792241 3928 2245730 SGTC_3075 9116269 49.47 µM -0.925099265047419 0.2030766360416 no 2715 0.177457137668502 4024 17015205 YNL244C SUI1 SGTC_726 3448-4391 34.2 µM -0.926700902889283 0.202674128113855 no 2716 0.177040924312157 4117 1356692 SGTC_3109 9122853 49.47 µM -0.929751934853284 0.201908693089009 no 2717 0.176249768893684 4069 1234709 SGTC_2199 6590217 200 µM -0.93086891277251 0.201628901875181 no 2718 0.175960688523081 3909 703109 SGTC_1250 0485-0349 40.2 µM -0.931326076063365 0.201514454296745 no 2719 0.175842458647082 4013 6842794 YDL195W SEC31 SGTC_2428 5615643 7.78 µM -0.932048844705012 0.201333593743986 no 2720 0.175655641582228 4052 2253075 SGTC_1684 st024538 14.6195 µM -0.935247287083031 0.200534406721534 no 2721 0.174830437052817 4004 6732859 SGTC_1623 st003709 20.3 µM -0.935825921639915 0.200390028476374 no 2722 0.174681411436649 3978 16192618 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.93666598906578 0.200180529867913 no 2723 0.174465198146209 4054 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1087 pterostilbene 9.05 µM -0.937505525353329 0.199971295277198 no 2724 0.174249291460052 4079 5281727 Similar to reservatol, lowers cholesterol. SGTC_1033 k072-0102 21.3 µM -0.93826823271833 0.199781322525768 no 2725 0.17405329041511 4005 5965931 SGTC_2082 5219693 150 µM -0.939486573702068 0.199478087294987 no 2726 0.173740491220705 4015 2834649 SGTC_1397 3532-0190 20.1 µM -0.941028201870358 0.199094785828001 no 2727 0.17334520351576 3959 5322280 SGTC_584 0986-0246 15.4 µM -0.941364669023737 0.199011187619933 no 2728 0.173259006407263 4115 53315 YDR232W HEM1 SGTC_2906 7926292 26.41 µM -0.942104182768527 0.198827523308334 no 2729 0.173069651613999 4046 2966319 SGTC_3230 9131665 49.47 µM -0.943689052671364 0.19843425215324 no 2730 0.172664284933256 3978 15943720 SGTC_2067 5224629 34.075 µM -0.944684319885566 0.198187525664586 no 2731 0.172410032279837 4034 2835000 SGTC_1356 1502-0781 85.8 µM -0.94502248771224 0.198103736117072 no 2732 0.172323697736379 3995 567702 SGTC_2080 5212524 12.4 µM -0.945184120076343 0.198063695207262 no 2733 0.172282442595264 3919 260183 SGTC_2170 morpholine 200 µM -0.946457615642818 0.197748385297859 no 2734 0.171957615276035 4056 121171 Reacts with secondary amines. SGTC_2148 5546263 113.568 µM -0.948603138901526 0.197217853013651 no 2735 0.171411246979386 4014 792097 SGTC_1254 0550-0035 264 µM -0.948633883335981 0.197210256975507 no 2736 0.17140342582697 4103 15121435 SGTC_63 0099-0242 26.702 µM -0.948816317358819 0.197165186579404 no 2737 0.171357020679144 4067 3898502 YLR359W ADE13 SGTC_427 1354-0053 47.3 µM -0.950540346134681 0.196739572417465 no 2738 0.170918881714834 4130 6813657 SGTC_96 0929-0093 37.281 µM -0.951414970427486 0.196523865219255 no 2739 0.170696881882867 4020 6991579 SGTC_2608 thymoquinone 42.66 µM -0.953512898490202 0.196007041004788 no 2740 0.170165132030515 4028 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_217 ketoconazole 989 nM -0.954131386564336 0.19585483408133 no 2741 0.170008570196841 3905 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2427 5545055 42.75 µM -0.956744085399939 0.195212653372148 no 2742 0.169348220319963 4006 5372858 SGTC_894 0960-0238 55.9 µM -0.957736353381939 0.194969097396823 no 2743 0.169097860225716 4045 6741907 YDL195W SEC31 SGTC_2128 5255449 168.493 µM -0.958774190444671 0.194714554096075 no 2744 0.168836256997669 4035 736008 SGTC_977 1348-1378 135 µM -0.960706803161241 0.194241094285058 no 2745 0.168349804794985 4036 X977 SGTC_1183 1254-0324 198 µM -0.961694121096246 0.193999487686523 no 2746 0.168101638166484 4126 5799357 SGTC_1004 4084-0029 199 µM -0.966519029064555 0.192821420457237 no 2747 0.166892264838077 4076 716894 YLR208W SEC13 SGTC_17 0960-0276 49.807 µM -0.967174662850363 0.192661676464416 no 2748 0.166728363043718 4046 6821114 SGTC_1044 1222-0021 1.78 µM -0.967696510803539 0.192534586971643 no 2749 0.16659798061038 4021 4306703 SGTC_1235 benzylparaben 21.5 µM -0.968094212334452 0.192437766193794 no 2750 0.166498660054992 4055 7180 SGTC_2899 9053889 58.44 µM -0.971750963589452 0.191548922857983 no 2751 0.165587228120251 4025 6470052 SGTC_400 oxethazaine 37.5 µM -0.973016681224612 0.191241852833827 no 2752 0.165272505759745 4071 4621 A local anesthetic. SGTC_104 0074-0074 590.992 µM -0.973410500414965 0.191146371729617 no 2753 0.165174661109824 3843 3943124 SGTC_378 3970-0959 8.33 µM -0.973858100737262 0.191037886934734 no 2754 0.165063500033529 4086 6615653 SGTC_1061 3448-9325 110 µM -0.97428353618072 0.190934809246166 no 2755 0.164957888487364 3957 723482 SGTC_3124 9127567 49.47 µM -0.974358479112135 0.190916655045851 no 2756 0.164939288932224 4063 17592030 SGTC_2800 7887935 81.82 µM -0.974432421132871 0.190898744344266 no 2757 0.164920939117041 4081 2961002 SGTC_846 0335-0850 148 µM -0.976423494559027 0.190416841673144 no 2758 0.164427321683704 4045 6819598 SGTC_1072 oxiconazole 14.9 nM -0.977030062644832 0.190270181625711 no 2759 0.164277134734163 4056 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2101 5377231 179.231 µM -0.977377452454895 0.190186218677228 no 2760 0.164191160693661 4107 2844213 SGTC_521 r062-0005 13.8 µM -0.980919475169669 0.189331423644947 no 2761 0.163316226374756 3981 2832033 SGTC_1729 st035615 45.989 µM -0.981615047472889 0.1891638396679 no 2762 0.163144765738929 4107 17385451 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.984123384974692 0.188560265823294 no 2763 0.162527425092592 4081 688751 SGTC_2593 nobiletin 86.24 µM -0.9860114016806 0.188106742139795 no 2764 0.162063758950066 4093 72344 An anti-infammatory. SGTC_275 trichlorophene 5.69 µM -0.98625176126427 0.188049053306911 no 2765 0.162004792432373 4114 62616 SGTC_1836 st055642 81 µM -0.986396343233324 0.188014357371668 no 2766 0.161969329410885 4083 8571 SGTC_2517 totarol 10 µM -0.988390141615071 0.187536300376598 no 2767 0.161480806882447 4089 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2445 5742597 35.57 µM -0.988920337198683 0.18740930087018 no 2768 0.161351059695729 4042 1774255 SGTC_1913 st060213 96.1 µM -0.990051135978422 0.187138614541723 no 2769 0.161074562687452 4126 688959 SGTC_155 k072-0202 43.6 µM -0.990464723509639 0.187039671948793 no 2770 0.160973511695654 3973 5857737 SGTC_385 1494-0393 12.4 µM -0.990830625892472 0.186952164064121 no 2771 0.160884146022142 4073 3090647 SGTC_1345 1488-0192 31.4 µM -0.991681821038179 0.186748693352213 no 2772 0.160676380856266 4129 658348 SGTC_546 peri-Naphthalide 147 µM -0.99238552717653 0.186580582138517 no 2773 0.160504748124557 3995 223824 A penicillin ester. SGTC_1336 1486-0901 104 µM -0.993419374684074 0.186333772142534 no 2774 0.160252811795371 4103 5006114 SGTC_2908 7930301 100 µM -0.994726458342452 0.186022022265199 no 2775 0.15993466124366 4068 2223178 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.995420339988236 0.185856657430191 no 2776 0.15976593503426 4100 7104 SGTC_961 1252-1571 372 µM -0.995795755128454 0.185767227073797 no 2777 0.159674696600711 4103 6813498 SGTC_2790 5423970 71.43 µM -0.996028106927207 0.185711890246052 no 2778 0.159618244428131 4149 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1657 st012939 43.4 µM -0.996879778774874 0.18550914381141 no 2779 0.159411434006978 4107 24207257 SGTC_2185 6113692 200 µM -0.997753484229791 0.185301294933902 no 2780 0.159199455572436 4097 874150 SGTC_2249 haloperidol 116.36 µM -0.997819854180654 0.185285511863322 no 2781 0.159183360442223 4071 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2638 epoxomicin 18 µM -0.99931079160561 0.184931180311291 no 2782 0.158822079655028 4073 9915668 A protesome inhibitor. SGTC_290 2043-6722 48.1 µM -1.00363229789074 0.183906525750762 no 2783 0.157777940406677 4107 773758 YLR208W SEC13 SGTC_2303 7774051 200 µM -1.00454331125141 0.183690971209525 no 2784 0.157558402948438 4135 2953184 SGTC_2930 9013230 14.89 µM -1.00647666816941 0.183234042097057 no 2785 0.157093164807487 4102 2995857 SGTC_988 1497-1057 103 µM -1.00701935926947 0.183105910132707 no 2786 0.156962735553209 4043 3533044 SGTC_2960 9079389 5.97 µM -1.00753022303351 0.182985343841543 no 2787 0.15684002072882 4100 16457355 SGTC_1489 4065-0444 182 µM -1.01074068245071 0.182228794353555 no 2788 0.156070280094011 4082 2877968 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.01091870867194 0.182186899498338 no 2789 0.156027669454331 3921 88881 An O-methylated flavonoid and antioxidant. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.01452647662797 0.181339182155582 no 2790 0.155165801114291 4144 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2694 st077685 81.9 µM -1.01477954690909 0.181279811068815 no 2791 0.155105462736984 4053 2838096 SGTC_2921 7974240 10.71 µM -1.01651153920548 0.180873807015317 no 2792 0.154692927684671 4193 2979074 YDR527W RBA50 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.01696198265565 0.180768310010058 no 2793 0.154585757595697 4127 2374 Ca(2+)-ATPase inhibitor. SGTC_815 1582-0027 36.9 µM -1.01979128010941 0.180106551164986 no 2794 0.153913729796342 4154 3128206 SGTC_2876 9059903 25.97 µM -1.02050736565133 0.179939303729617 no 2795 0.153743948896904 4091 6916095 SGTC_1703 st026983 48.3 µM -1.02119341096632 0.179779163938681 no 2796 0.153581406740468 4133 1104023 SGTC_2861 9024595 19.48 µM -1.02284847564255 0.179393199953483 no 2797 0.153189747007794 4003 16482810 SGTC_2791 5663188 71.43 µM -1.02542556581625 0.178793256028179 no 2798 0.152581215090496 4164 54690634 SGTC_1499 4480-0877 67.3 µM -1.02710675030376 0.178402559563556 no 2799 0.152185100224227 4054 2861909 SGTC_64 000l-0018 272.079 µM -1.02778641491159 0.178244762675623 no 2800 0.152025153996742 4046 6811119 SGTC_2545 solidagenone 89.61 µM -1.03086356077247 0.177531446655643 no 2801 0.151302403330453 3940 6708572 An anti ulcer agent SGTC_2383 9036125 200 µM -1.0312952993688 0.17743150925813 no 2802 0.151201181001359 4049 79580 SGTC_935 2996-0153 430 µM -1.03218691501143 0.177225233502322 no 2803 0.150992281818148 4151 23738523 SGTC_2518 prenyletin 46.28 µM -1.03528326374622 0.17651006843592 no 2804 0.150268321743394 4085 3873459 A coumarin with calcium channel inhibitory activity. SGTC_789 1309-1135 70.6 µM -1.03589597198189 0.176368767575523 no 2805 0.150125338506216 4113 3092424 SGTC_192 3455-0609 60.9 µM -1.04033272676818 0.175347713432567 no 2806 0.149092672272022 4199 3769639 SGTC_1810 st050138 53 µM -1.04073868353262 0.175254475944449 no 2807 0.148998422269516 4141 3444541 SGTC_261 5-fluorouridine 15.376 µM -1.04084985621072 0.175228948017374 no 2808 0.148972618521279 4147 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1798 st045719 60.953 µM -1.04456472103346 0.174377281704104 no 2809 0.148112095953474 4033 3980186 SGTC_435 c-PAF 6.7 µM -1.04484668885521 0.174312745586773 no 2810 0.148046916165577 4128 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2180 6301957 200 µM -1.04729764014711 0.17375241714954 no 2811 0.147481162075309 4157 845462 SGTC_1445 4239-0156 97.7 µM -1.0480071326701 0.17359042937336 no 2812 0.147317660329896 4217 4008346 SGTC_2162 5663267 200 µM -1.04975219818845 0.173192413772109 no 2813 0.146916028997804 4136 6456493 SGTC_1689 st020265 53.493 µM -1.05391296699854 0.172245770062856 no 2814 0.145961382799454 4149 5758320 YPR016C TIF6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.0560778127906 0.171754540129849 no 2815 0.145466333049377 4126 442882 SGTC_2068 5226020 147 µM -1.05670233599777 0.171612994658247 no 2816 0.145323729276682 4178 1810509 SGTC_2060 5238662 140 µM -1.05687453876514 0.171573978761004 no 2817 0.14528442500415 4147 790130 SGTC_3079 9117512 49.47 µM -1.05873902150924 0.171151906751094 no 2818 0.144859325683794 4207 7185044 SGTC_1871 st057448 67.3 µM -1.05880667250048 0.171136604761481 no 2819 0.144843917119111 4211 691747 SGTC_1352 1496-0991 99 µM -1.05930058936492 0.171024912132557 no 2820 0.144731453320038 4129 3000039 SGTC_2103 5378138 10 µM -1.06036750445137 0.170783802884893 no 2821 0.144488719843825 4223 244142 SGTC_456 gingerol 170 µM -1.06206107121145 0.170401525278448 no 2822 0.144103980647588 4206 442793 A herb. SGTC_3196 9111891 49.47 µM -1.06235847091765 0.170334451826141 no 2823 0.144036489684109 4147 18891510 SGTC_2086 5274770 176.623 µM -1.06278330750701 0.170238666488449 no 2824 0.143940115571917 4189 689278 SGTC_1143 3454-2408 5.08 µM -1.06279644688164 0.170235704583352 no 2825 0.143937135600453 4144 X1143 SGTC_3292 9120825 59.784 µM -1.06368548918769 0.170035371520199 no 2826 0.143735600086093 4165 24824900 SGTC_1609 st001574 46.4 µM -1.06438534450921 0.169877775397767 no 2827 0.143577085056069 4134 3960012 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.06441813473248 0.169870393866196 no 2828 0.143569661068396 4105 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1502 4534-4282 27.7 µM -1.06476106969182 0.169793206799004 no 2829 0.143492033178915 4108 3278949 SGTC_2888 9058547 12.99 µM -1.06671201436809 0.169354520365292 no 2830 0.143050950083163 4062 16476514 SGTC_3060 1327-0027 12.5 µM -1.06840476343205 0.168974481372458 no 2831 0.142668984626087 4062 16000455 YPR107C YTH1 SGTC_274 sirtinol 40.1 µM -1.07182546602378 0.168208173050944 no 2832 0.141899216293112 4223 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1186 1319-0216 26 µM -1.0738048482193 0.167765773163452 no 2833 0.141455078276081 4239 4565136 SGTC_1344 1488-0097 29.1 µM -1.07426442075591 0.167663164118914 no 2834 0.141352093305665 4199 747966 SGTC_1562 morin hydrate 59.1 µM -1.07429684250742 0.167655926821011 no 2835 0.141344829880018 4231 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3036 9090181 49.47 µM -1.07510946531156 0.167474596010606 no 2836 0.141162861109301 4208 25236586 SGTC_169 k015-0017 16.025 µM -1.07512067181165 0.167472096246027 no 2837 0.141160352774175 4125 1840002 SGTC_2932 9016711 44.54 µM -1.07620965669024 0.16722929780588 no 2838 0.140916750970756 4185 7117328 SGTC_2650 prasterone 100 µM -1.07820291678147 0.166785471589107 no 2839 0.140471605283657 4144 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2808 7946468 45.46 µM -1.07832691005998 0.166757887945351 no 2840 0.14044394600592 4167 2970879 SGTC_3144 9087057 49.47 µM -1.07870227918657 0.166674400973913 no 2841 0.140360234663445 4072 17249618 SGTC_2301 7769476 200 µM -1.07871981869298 0.1666705006195 no 2842 0.140356323994095 4199 977820 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.07921306798801 0.166560838239371 no 2843 0.140246377713179 4105 4330530 SGTC_2629 bisabolol 100 µM -1.08163371523857 0.166023339547153 no 2844 0.139707658552527 4212 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2879 9041815 71.43 µM -1.08182349770424 0.16598124625635 no 2845 0.139665481698967 4182 4942971 SGTC_2827 7993847 71.43 µM -1.08362188842023 0.165582709916907 no 2846 0.139266240887522 4257 2985692 SGTC_1391 3442-0225 151 µM -1.08732899318149 0.164763143223338 no 2847 0.138445719837172 4149 5227075 SGTC_908 3448-7491 47.7 µM -1.08748169511819 0.164729440327015 no 2848 0.138411991978222 4183 1203031 SGTC_1649 st011737 51.3 µM -1.08978038492973 0.164222635430011 no 2849 0.137904948209172 4184 1761035 SGTC_3257 9139206 32.98 µM -1.09185603737476 0.16376587450796 no 2850 0.137448191844174 4183 4910041 SGTC_1630 st005209 31.3 µM -1.09197253676238 0.16374026251772 no 2851 0.137422586295366 4161 3367314 SGTC_2053 5265679 138 µM -1.09380612499663 0.163337496973702 no 2852 0.137020008620608 4105 764595 SGTC_2742 clothiapine 36.27 µM -1.09381815429321 0.163334856748202 no 2853 0.137017370164274 4186 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2354 9060492 162 µM -1.09587459091436 0.162883911481749 no 2854 0.136566830021424 4224 6471895 SGTC_3178 9107506 49.47 µM -1.09872923073235 0.162259275548495 no 2855 0.135943094303213 4200 8897194 SGTC_84 0443-0269 128.823 µM -1.10595791894269 0.160684519449899 no 2856 0.134372366879213 4123 6150058 SGTC_2760 etidronate 98.04 µM -1.10728179589967 0.160397200334134 no 2857 0.134086056195425 4155 3305 A chelator and antioxidant. SGTC_1892 st058411 7.36 µM -1.10855495443612 0.160121205420857 no 2858 0.133811109828961 4212 3934738 SGTC_1303 1160-0052 261 µM -1.11081748383369 0.159631501615618 no 2859 0.133323459586523 4140 3562476 SGTC_1990 st072050 59.8 µM -1.11472727660531 0.158787575421235 no 2860 0.132483654281317 4199 17233948 SGTC_2307 7538926 6.34 µM -1.11959169149477 0.157741685037695 no 2861 0.131443898880496 4179 96582 SGTC_794 k038-0031 316 µM -1.12000388073805 0.15765326929684 no 2862 0.131356054178982 4200 6624242 SGTC_254 nsc-64875 3.808 µM -1.12091342746803 0.157458284198702 no 2863 0.131162357378124 4211 56993 SGTC_2493 resveratrol 26.09 µM -1.12154974488368 0.15732196720758 no 2864 0.131026964757792 4135 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2481 5478948 45.16 µM -1.12449639882924 0.15669172326778 no 2865 0.130401248690764 4241 77792 SGTC_3195 9113082 49.47 µM -1.12484543038101 0.156617181022252 no 2866 0.13032726967669 4210 17018038 SGTC_2052 5265182 7.135 µM -1.12631587175206 0.156303397020894 no 2867 0.13001592098572 4218 1239884 SGTC_2801 7907800 81.82 µM -1.1265848472813 0.156246043974099 no 2868 0.129959024324154 4233 6620925 SGTC_1739 st037196 92.5 µM -1.13189976161402 0.155115600558561 no 2869 0.128838289466274 4281 612214 SGTC_780 0109-0199 192 µM -1.13285282743559 0.154913462823126 no 2870 0.12863803129103 4304 610414 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.13378581005419 0.154715753172084 no 2871 0.1284422023146 4252 61125 An anti-inflammatory. SGTC_3101 9120531 49.47 µM -1.13455936557811 0.154551954418008 no 2872 0.128279993384772 4249 24824904 SGTC_1779 st039427 55 µM -1.1352329542681 0.154409416821712 no 2873 0.128138862672586 4207 1124498 SGTC_113 0099-0221 2.5 µM -1.1383898052489 0.153742556417475 no 2874 0.127478874564855 4199 89219 SGTC_1434 4073-0095 163 µM -1.14393074560413 0.152576692131056 no 2875 0.126326179549949 4206 24133745 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.1480487999632 0.151714025596017 no 2876 0.125474209395386 4312 4213774 SGTC_2846 9008642 19.48 µM -1.14860132848785 0.151598526827882 no 2877 0.125360204509665 4281 2992898 SGTC_2323 6148992 148.28 µM -1.1503849800207 0.151226077088335 no 2878 0.124992671837522 4215 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1111 tnp00062 510.699 nM -1.15155495077609 0.150982102769267 no 2879 0.124752001142891 4285 676306 SGTC_1673 st016611 27.3 µM -1.15158225496324 0.150976412149472 no 2880 0.124746388361384 4264 5226799 SGTC_2088 5278280 127.392 µM -1.15160667359553 0.150971323045369 no 2881 0.124741368898055 4283 791502 SGTC_597 k018-0003 82.8 µM -1.15187834873954 0.150914710741196 no 2882 0.124685533218097 4311 6786234 SGTC_1410 3909-8106 77.9 µM -1.15753752811908 0.149738650543 no 2883 0.123526408002838 4290 1039210 SGTC_1237 0330-0133 46.1 µM -1.15824950487223 0.149591125525801 no 2884 0.123381115635763 4187 X1237 YHR072W ERG7 SGTC_2109 5483026 200 µM -1.15847363474411 0.149544704813738 no 2885 0.123335402468817 4257 759335 SGTC_1954 st077032 68.9 µM -1.15899293822975 0.1494371860928 no 2886 0.123229531770846 4204 698907 SGTC_898 1000-0849 28.3 µM -1.16260256839486 0.148691259567758 no 2887 0.122495394123031 4252 6751807 SGTC_3339 9145883 14.936 µM -1.16495530027129 0.148206411893808 no 2888 0.122018543502613 4155 2030670 SGTC_2605 digitonin 300 nM -1.16560557375428 0.148072591242753 no 2889 0.121886976632265 4274 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1271 0832-2808 169 µM -1.16633581965041 0.147922409384296 no 2890 0.121739348135147 4292 3663794 SGTC_73 0327-0325 16.231 µM -1.16680800516931 0.147825354344321 no 2891 0.121643956736485 4104 53298 SGTC_1114 scopoletin 1.73284 µM -1.16926330341914 0.1473213691836 no 2892 0.121148781638663 4283 5280460 A coumarin with genotoxic properties. SGTC_1485 3909-9022 254 µM -1.16972160331177 0.147227424247233 no 2893 0.121056510728283 4314 714516 SGTC_760 0568-0725 82.9 µM -1.17459826225494 0.146230266035051 no 2894 0.120077739432785 4294 3916171 SGTC_753 1322-0200 289 µM -1.18047923446247 0.145033796451525 no 2895 0.118904832340142 4333 5403907 SGTC_2934 9036370 36.88 µM -1.18120549033841 0.1448864998801 no 2896 0.118760550366966 4249 6462800 SGTC_2297 7971671 152.32 µM -1.18196393386775 0.14473278267884 no 2897 0.118610005884371 4281 909016 SGTC_1988 st071872 53.4 µM -1.18353348152901 0.144415024268218 no 2898 0.118298892633083 4303 16414116 SGTC_2887 9044784 58.44 µM -1.18401977684319 0.144316668170617 no 2899 0.11820261712101 4225 6465546 SGTC_3042 9091578 49.47 µM -1.18745577717691 0.143623003535374 no 2900 0.117523945079408 4263 25236497 SGTC_2358 9037157 4 µM -1.18784803269021 0.143543957781992 no 2901 0.117446643344987 4281 2388925 SGTC_341 1486-1430 230 µM -1.18902402561468 0.143307152436995 no 2902 0.11721510638742 4225 2054753 YPL210C SRP72 SGTC_468 gf-109203x 121 µM -1.19019830771502 0.143070954976949 no 2903 0.11698422909029 4291 2396 A protein kinase C inhibitor. SGTC_1821 st053465 65.6 µM -1.19169952395243 0.142769380576318 no 2904 0.116689542398711 4285 675086 SGTC_1565 sinapyl alcohol 95.1 µM -1.19471645033506 0.142164620493255 no 2905 0.116098916502751 4291 5280507 A phenol propionate derived from cinnamic acid. SGTC_2568 diosmetin 100 µM -1.19522429565101 0.142062990736977 no 2906 0.115999704274012 4324 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3320 9137005 35.139 µM -1.19549233739444 0.142009370187165 no 2907 0.115947364140755 4316 4908713 SGTC_2756 carbadox 75.1 µM -1.19566432977761 0.141974971098613 no 2908 0.115913788263061 4223 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_271 rotenone 740 µM -1.19652100789689 0.141803716457403 no 2909 0.115746652756206 4329 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_559 1550-0661 158 µM -1.19865416728028 0.141377894305594 no 2910 0.115331223236407 4337 5830875 SGTC_1855 st056195 39.6 µM -1.2006624871445 0.140977785505877 no 2911 0.114941075588196 4223 4028379 SGTC_1260 0700-1617 7.75 µM -1.20086454587604 0.140937572792423 no 2912 0.114901874544883 4271 2853078 SGTC_2506 ethyl hematommate 54.16 µM -1.20164614083863 0.140782096952843 no 2913 0.114750328283529 4348 3940691 An allergen. SGTC_2946 9065502 71.43 µM -1.20191020014676 0.140729596257871 no 2914 0.114699161026695 4112 16489101 SGTC_2926 9010726 65.15 µM -1.20213626279083 0.140684660677624 no 2915 0.114655369353472 4304 2994293 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.20644041243288 0.139830961223396 no 2916 0.11382386088454 4289 5379071 SGTC_835 0312-0010 67.2 µM -1.20820881021495 0.139481233974394 no 2917 0.113483476890138 4291 1626196 SGTC_482 fipronil 114 µM -1.20845909231084 0.139431785028974 no 2918 0.113435360894842 4395 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3177 9107506 49.47 µM -1.20881226028891 0.139362028915267 no 2919 0.113367490144074 4244 8897194 SGTC_2206 7254556 146.969 µM -1.21200759441647 0.138731980418843 no 2920 0.112754736782679 4314 4398905 SGTC_2953 9074162 66.49 µM -1.21525576767052 0.138093504618988 no 2921 0.112134278241211 4291 16451992 SGTC_2933 9026794 32.47 µM -1.21597210289086 0.137952968603677 no 2922 0.111997774625988 4245 17586027 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.21880080205448 0.137398966641223 no 2923 0.111459903512404 4181 4000243 SGTC_1940 st075990 51.1 µM -1.22560000195949 0.136073561170767 no 2924 0.110174618554607 4382 1084979 SGTC_769 0302-0231 76 µM -1.22697705692316 0.13580619357816 no 2925 0.109915607137731 4210 571869 YER009W NTF2 SGTC_2486 5283202 22.39 µM -1.22929512121764 0.135356933588515 no 2926 0.10948058791751 4345 1377751 SGTC_620 0109-0052 432 µM -1.23156169807259 0.134918638284839 no 2927 0.10905642801187 4343 493037 SGTC_2806 7952793 58.44 µM -1.23804889798612 0.133669572252077 no 2928 0.107848965190611 4359 2972490 SGTC_1211 1056-0033 32.3 µM -1.24014181540259 0.133268296989421 no 2929 0.107461472425605 4375 6741922 SGTC_1561 5-methoxyflavone 52.9 µM -1.24129893937269 0.133046797655593 no 2930 0.107247668183729 4281 94525 SGTC_1138 3761-0006 1.03 µM -1.24137628704169 0.133032000627682 no 2931 0.107233387435211 4348 12061087 SGTC_943 3253-1379 105 µM -1.24247923408692 0.132821124129542 no 2932 0.107029898786835 4323 668464 SGTC_1208 2323-2347 50.3 µM -1.24530318020735 0.132282253073727 no 2933 0.106510163561268 4325 5412760 SGTC_1170 0310-0127 64.8 µM -1.24682951834639 0.131991622412095 no 2934 0.106230007273077 4327 774975 SGTC_696 1560-0013 611 µM -1.24826896938941 0.131717939723798 no 2935 0.105966286977076 4378 1650269 SGTC_2669 eugenol 100 µM -1.25314636473936 0.130793513438662 no 2936 0.105076222587036 4332 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2865 9030313 51.95 µM -1.25740660163908 0.129989736143829 no 2937 0.104303219976654 4309 42562754 SGTC_1225 1216-0074 20.6 µM -1.25755404840023 0.12996197876964 no 2938 0.104276540349328 4340 4241466 SGTC_1796 st049173 110.4 µM -1.25755609906988 0.129961592752758 no 2939 0.10427616932755 4296 94134 SGTC_1074 carmofur 3.8 µM -1.26141801095246 0.129236036501973 no 2940 0.103579141275721 4381 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1475 4092-1048 11.7 µM -1.26240872571792 0.129050359487893 no 2941 0.103400875513254 4332 2881759 SGTC_1818 st052136 56.3 µM -1.26466632629581 0.128627937513354 no 2942 0.102995482949553 4002 674169 SGTC_2977 9011197 71.43 µM -1.26892227711199 0.127834213798385 no 2943 0.102234393040805 4395 2704722 SGTC_1427 4048-4900 550 nM -1.27013908034982 0.12760791017838 no 2944 0.102017546518182 4333 24132586 SGTC_774 k060-0086 136 µM -1.271079434644 0.127433212013729 no 2945 0.101850195374824 4340 5911235 SGTC_2440 5628896 157.78 µM -1.27134815697313 0.127383319595134 no 2946 0.101802408652556 4321 5522048 SGTC_1496 4469-0713 57.4 µM -1.27167318249864 0.127322991781312 no 2947 0.101744631379584 4317 746691 SGTC_635 k038-0028 24.7 µM -1.27233170512777 0.127200824677814 no 2948 0.101627644094467 4336 4035102 SGTC_795 0685-0265 78 µM -1.27458304192732 0.126783779678229 no 2949 0.101228431453814 4354 302754 SGTC_2710 st078562 53.7235 µM -1.27847432375238 0.126065192688769 no 2950 0.10054111623192 4287 17250908 SGTC_3313 9133968 57.047 µM -1.28244062465619 0.12533567935729 no 2951 0.0998440604831458 4343 1494643 SGTC_1018 4259-0013 28.1 µM -1.28544689844156 0.124784708777667 no 2952 0.0993180808112573 4401 6801262 SGTC_297 0986-0032 24 µM -1.28612741144339 0.124660224002059 no 2953 0.0991992994974119 4329 2847425 SGTC_1949 st076024 69.1 µM -1.28900435090645 0.12413491093182 no 2954 0.098698286989777 4309 2921930 SGTC_1563 conessine 56.1 µM -1.28906618901654 0.124123636666166 no 2955 0.0986875383915799 4439 441082 An anti-amoebic, histamine inhibitor. SGTC_1201 1889-3372 45.9 µM -1.29173323716819 0.123638064592018 no 2956 0.0982247714632597 4242 5392199 SGTC_87 0100-0052 35.5 µM -1.2924208998809 0.123513082310824 no 2957 0.0981057113666618 4398 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_515 4092-1064 102 µM -1.29382122224581 0.123258848205742 no 2958 0.0978635902138883 4345 717353 SGTC_3289 9119912 71.43 µM -1.29603419984971 0.122857821361434 no 2959 0.0974818512874778 4373 17014829 SGTC_2721 ifenprodil 61.44 µM -1.29773676364892 0.122549913009955 no 2960 0.0971889030047629 4363 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1942 st076330 65.2 µM -1.29782069116959 0.122534748748452 no 2961 0.0971744789074637 4419 24208414 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.29959793549818 0.122213940316877 no 2962 0.0968694038212598 4365 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2002 4023503 131 µM -1.29964637198844 0.122205205360846 no 2963 0.0968610992505072 4354 4736863 YCR052W RSC6 SGTC_198 3454-2873 16.191 µM -1.29998242024957 0.122144615045979 no 2964 0.0968034972371155 4374 710957 SGTC_331 k048-0133 24.5 µM -1.30101706770291 0.121958198062834 no 2965 0.0966263063289601 4322 6813582 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.30213760036573 0.121756532266085 no 2966 0.0964346758041952 4380 551469 SGTC_57 miconazole 162.5 nM -1.30348113690599 0.12151504079254 no 2967 0.0962052760761397 4217 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_327 1273-0057 3.96 µM -1.3044783077053 0.121336023996574 no 2968 0.0960352754693719 4273 3108138 SGTC_2563 tomatine 8.54 µM -1.30478108406983 0.121281704878755 no 2969 0.0959837010082788 4331 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1775 st081588 35.1725 µM -1.30530370084785 0.121187985874553 no 2970 0.0958947271936117 4356 1426443 YGL099W LSG1 SGTC_1920 st075728 45.7 µM -1.30763205321751 0.120771069756062 no 2971 0.0954990698160628 4351 3400306 SGTC_3069 9117009 49.47 µM -1.31204270617945 0.119984065573924 no 2972 0.0947528627816754 4363 41904981 SGTC_2434 5670830 169.91 µM -1.31536593048589 0.119393486873686 no 2973 0.0941934749377086 4394 1549830 SGTC_2799 7812892 81.82 µM -1.31554036264425 0.119362544845137 no 2974 0.0941641807575751 4402 20205235 SGTC_1185 1319-0113 81.3 µM -1.32085247717466 0.118422952820435 no 2975 0.0932752790315671 4441 4672763 SGTC_2835 9006588 71.43 µM -1.32120455490535 0.118360863545317 no 2976 0.0932165839885289 4390 2345538 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.32189139487513 0.118239804844821 no 2977 0.0931021591379202 4413 65057 A dermal irritant. YDR527W RBA50 SGTC_3104 9120930 49.47 µM -1.3225470003621 0.118124333057509 no 2978 0.0929930346967494 4402 17014836 SGTC_3319 9138450 16.7555 µM -1.32477529565257 0.117732459694318 no 2979 0.0926228454570998 4310 2029690 SGTC_504 lovastatin 124 µM -1.32676571910264 0.117383197789445 no 2980 0.0922930968535178 4406 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1305 1181-0477 144 µM -1.32795687747361 0.11717453512285 no 2981 0.0920961765615889 4445 6252086 SGTC_129 0088-0017 176.636 µM -1.32799648356298 0.117167601593012 no 2982 0.0920896342973907 4239 182446 SGTC_2891 9063876 19.48 µM -1.32847920800306 0.117083118140941 no 2983 0.0920099239377617 4405 6472478 SGTC_200 k038-0079 37.545 µM -1.32849335903995 0.117080642165164 no 2984 0.0920075880045726 4374 3436683 SGTC_997 3996-0078 137 µM -1.32971011186996 0.116867888318946 no 2985 0.0918069009450375 4425 735687 SGTC_1866 st057638 64 µM -1.33281506783746 0.116326217280476 no 2986 0.0912962498601492 4375 688802 SGTC_40 0327-0103 19.753 µM -1.33305509445216 0.116284418045346 no 2987 0.0912568621707704 4228 409036 SGTC_1655 st012546 55.1 µM -1.33759945238895 0.115495054814566 no 2988 0.0905135215305323 4378 720985 YLR208W SEC13 SGTC_2436 5633522 8.09 µM -1.33760303760672 0.115494433562506 no 2989 0.0905129368606312 4382 5724242 SGTC_2639 lactacystin 53 µM -1.33844132843453 0.115349238415315 no 2990 0.0903763070851644 4415 3870 A proteasome inhibitor. SGTC_2382 9035899 200 µM -1.33873653730068 0.115298138021841 no 2991 0.0903282286169455 4382 6462679 SGTC_1872 amphotericin b 148 nM -1.34070760915217 0.11495735959699 no 2992 0.0900077015453527 4401 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2369 9071472 200 µM -1.34222075621126 0.114696238239525 no 2993 0.0897622142066366 4420 17296037 SGTC_2747 doxorubicin 7.63 µM -1.34241214087931 0.114663241385209 no 2994 0.0897312001632117 4426 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.34456950309887 0.114291755230876 no 2995 0.0893821486937575 4389 688662 SGTC_2521 angolensin 13.4 µM -1.34471607966783 0.114266546662947 no 2996 0.0893584699609287 4430 821428 A flavenoid. SGTC_1690 st023502 41.2 µM -1.34565883912949 0.114104503398679 no 2997 0.0892062832667056 4405 24207482 SGTC_453 enantio-paf c16 10 µM -1.34740444511014 0.113804897637923 no 2998 0.0889250048798061 4089 13871343 A lipid and platelet activating factor SGTC_1875 nocodazole 6 µM -1.34854440128454 0.113609544990294 no 2999 0.0887416746455455 4431 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1617 st002906 78 µM -1.348942169862 0.113541436258801 no 3000 0.0886777709227439 4387 5150859 SGTC_1081 sertraline 6 µM -1.35065072713322 0.113249216182649 no 3001 0.0884036714902362 4383 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3261 9137475 49.47 µM -1.35160704300638 0.113085888777485 no 3002 0.0882505280291913 4396 17027690 SGTC_2746 daunorubicin 9.88 µM -1.35269373615777 0.112900498586292 no 3003 0.0880767461878173 4391 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_519 k048-0011 62.8 µM -1.35606182635304 0.112327279890106 no 3004 0.0875397486931611 4421 6836379 SGTC_2342 7990637 118.86 µM -1.3630153317439 0.111150441210628 no 3005 0.0864388393574366 4400 2033102 YER133W GLC7 SGTC_2491 paeonol 100 µM -1.36501102358462 0.110814318841058 no 3006 0.0861247926603403 4372 11092 Increases levels of cortical cytochrome oxidase. SGTC_360 0957-0399 1.01 µM -1.36752609404403 0.110391758702442 no 3007 0.0857302319952472 4430 6752301 YPR165W RHO1 SGTC_2484 5809818 12.04 µM -1.36790688093996 0.110327883056181 no 3008 0.0856706128252053 4384 2870548 SGTC_234 nsc-17383 10.7 µM -1.36842522289396 0.110240975639673 no 3009 0.0855895067822241 4430 408974 SGTC_2807 7945238 51.95 µM -1.3694141965109 0.110075296346617 no 3010 0.0854349195462123 4397 17148797 SGTC_643 k048-0106 28.4 µM -1.37016517174381 0.109949607469262 no 3011 0.0853176737831882 4428 6763920 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.37168245327119 0.109695978096024 no 3012 0.0850811565565713 4437 5357218 A potent inhibitor of glutathione S-transferases. SGTC_998 3996-0085 177 µM -1.37571368308512 0.109024157266319 no 3013 0.0844551469923419 4440 715391 SGTC_309 k408-0051 1.48 µM -1.3758252577588 0.109005605044889 no 3014 0.0844378698437925 4335 3640463 SGTC_1227 3909-8010 46.6 µM -1.3764458466685 0.108902457241089 no 3015 0.0843418210977694 4408 15982272 SGTC_2910 7948405 25.97 µM -1.37676957302023 0.108848678686501 no 3016 0.0842917504159895 4374 2971328 SGTC_2374 9071832 200 µM -1.37766363474758 0.108700253215102 no 3017 0.084153581974865 4354 17381698 SGTC_2040 5100729 123 µM -1.37949060630447 0.108397405727343 no 3018 0.0838717702680865 4451 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2370 9071495 200 µM -1.38263127588321 0.107878213198697 no 3019 0.0833889770336241 4422 21791103 SGTC_3072 9116419 49.47 µM -1.38287798496856 0.107837505056564 no 3020 0.0833511408404649 4437 17170162 SGTC_1353 1498-1206 8.11 µM -1.38769684039132 0.107044589167549 no 3021 0.0826146892807464 4454 6756808 SGTC_3084 9116877 49.47 µM -1.38981647170284 0.106697150455422 no 3022 0.0822923074803466 4380 27241325 SGTC_1132 3456-3614 2.5 µM -1.3913746746722 0.106442257664764 no 3023 0.0820559200694531 4426 3125502 SGTC_1906 st060206 94.7 µM -1.39267322114339 0.10623017591221 no 3024 0.0818593149955316 4454 5133468 SGTC_1967 st070177 51.4 µM -1.39279507554075 0.106210290032745 no 3025 0.0818408839936596 4436 5729214 SGTC_2264 7948757 110.76 µM -1.3954556440008 0.105776771909416 no 3026 0.0814392408181055 4397 2971411 SGTC_2093 5331342 194.4 µM -1.39727683010387 0.105480762728935 no 3027 0.0811651702730768 4474 33839 SGTC_852 0418-0143 439 µM -1.40120909925022 0.104843669897296 no 3028 0.0805757770477767 4429 5369229 SGTC_677 0929-0063 136 µM -1.4027822868388 0.104589569273066 no 3029 0.0803408853010099 4461 1539583 SGTC_294 k038-0071 157 µM -1.40388972962625 0.104410963308093 no 3030 0.0801758442261064 4452 24152826 SGTC_2117 5521686 200 µM -1.4087664845805 0.10362708025525 no 3031 0.0794521142421022 4415 803312 SGTC_2989 9073649 71.4286 µM -1.41063808545131 0.103327378371404 no 3032 0.0791756778441625 4424 21367202 SGTC_3277 9138724 49.47 µM -1.4120198983659 0.10310651102221 no 3033 0.0789720511460647 4400 15943418 SGTC_2029 5175081 200 µM -1.41328955135308 0.102903873632614 no 3034 0.0787853024668506 4406 1380876 SGTC_1010 4112-3296 15.2 µM -1.4165402767909 0.102386374966129 no 3035 0.0783086902188716 4476 704384 SGTC_1717 st033143 58.0435 µM -1.41873000882039 0.102038849358847 no 3036 0.0779888724300062 4479 674616 SGTC_2670 beta-carotene 100 µM -1.41950758248987 0.101915649784246 no 3037 0.0778755439158888 4413 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_828 2074-0507 139 µM -1.41953492302761 0.101911319892262 no 3038 0.0778715614082807 4497 X828 SGTC_2738 aclarubicin 5.55 µM -1.42203754527808 0.101515549071469 no 3039 0.077507675881112 4483 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_933 2914-0560 114 µM -1.42535141594579 0.1009932095277 no 3040 0.077027822250678 4459 463887 SGTC_2457 5731572 11.68 µM -1.42886334202377 0.100441793335542 no 3041 0.0765217577311697 4498 2865357 SGTC_2971 9092186 9.93 µM -1.43115521758486 0.100083126870905 no 3042 0.0761928674481225 4416 25236400 SGTC_2123 5259487 200 µM -1.43173349526041 0.0999927773774427 no 3043 0.0761100532791591 4460 2173474 SGTC_3096 9117468 49.47 µM -1.43253272268451 0.0998680049929624 no 3044 0.0759957100834026 4410 41316311 SGTC_2904 7225135 42.03 µM -1.43294017648822 0.0998044386178295 no 3045 0.0759374671850555 4518 4446116 SGTC_1404 3909-7820 48.3 µM -1.43454032388979 0.0995550875055364 no 3046 0.0757090652255823 4458 23741373 SGTC_3287 9117173 37.0625 µM -1.4373622696782 0.0991164534156638 no 3047 0.075307541879972 4476 2789709 SGTC_2127 5253358 187.912 µM -1.44100820073483 0.0985518367039184 no 3048 0.0747911829960239 4379 20612 SGTC_2469 5655019 90.81 µM -1.44354379522828 0.098160559656723 no 3049 0.0744336723532491 4519 2788239 SGTC_3193 9111931 49.47 µM -1.44434869796719 0.0980365904013175 no 3050 0.0743204569119803 4456 17087244 SGTC_348 k064-0012 10.7 µM -1.44705661116192 0.0976203661243128 no 3051 0.0739405344078089 4410 5066323 SGTC_2857 9024691 58.44 µM -1.45006937314756 0.0971588090313229 no 3052 0.0735195873588755 4493 16478292 SGTC_1522 st012842 45.6 µM -1.45214647470009 0.0968415297172859 no 3053 0.0732304409171171 4310 3491067 YOR116C RPO31 SGTC_3266 9136860 49.47 µM -1.45812872333489 0.0959319872796631 no 3054 0.0724025327664067 4237 4871271 YPR165W RHO1 SGTC_2441 5730946 39.09 µM -1.4604692760291 0.0955778442406643 no 3055 0.0720805727664919 4517 1774275 SGTC_143 4032-1194 15.74 µM -1.46205495893645 0.095338465900333 no 3056 0.0718630750073607 4500 1806963 SGTC_2523 spermine 47.74 µM -1.46245639584272 0.0952779341354224 no 3057 0.0718080924488253 4484 1103 A DNA binding polyamine. SGTC_705 1124-0212 310 µM -1.46307315142394 0.0951849900948531 no 3058 0.0717236817718417 4470 9554485 SGTC_2163 5671233 125 µM -1.46455335395447 0.0949621984736552 no 3059 0.07152140818849 4439 701023 SGTC_1758 st042942 75.2445 µM -1.46921593076422 0.0942629252171986 no 3060 0.0708871153292771 4448 669317 SGTC_3160 9100216 49.47 µM -1.47280214231681 0.0937276700969617 no 3061 0.0704021972615529 4459 17191039 SGTC_2041 5107442 45.335 µM -1.47572122430404 0.0932936457021825 no 3062 0.0700093729035057 4505 793005 SGTC_3073 9114972 49.47 µM -1.47641232547792 0.0931911069015374 no 3063 0.069916617945287 4482 41905075 SGTC_2598 perillyl alcohol 100 µM -1.47780010240097 0.0929854537669626 no 3064 0.0697306454872099 4492 10819 An apoptosis inducer. SGTC_911 3456-4043 236 µM -1.47933338645593 0.0927586283970388 no 3065 0.0695256170004391 4467 914281 SGTC_1318 1280-3875 124 µM -1.4815341345007 0.0924337776905664 no 3066 0.0692321479306756 4492 373245 SGTC_2502 avocadyne acetate 18.59 µM -1.48199992281172 0.0923651311079853 no 3067 0.0691701577512145 4423 3952079 SGTC_1975 st070967 30.8 µM -1.4878136250725 0.0915114957105995 no 3068 0.0684000257200928 4474 261391 SGTC_134 0269-0018 6.916 µM -1.49430225767563 0.0905656794466093 no 3069 0.0675483176605103 4438 4378915 SGTC_3202 9113761 49.47 µM -1.4994040435878 0.0898271278796741 no 3070 0.0668844226161928 4411 4798415 SGTC_1642 st009582 77.7 µM -1.50508580072688 0.089009897271649 no 3071 0.0661510095484539 4488 6739311 SGTC_1693 xanthone 101.9 µM -1.50690683262001 0.0887491454050457 no 3072 0.0659172699233196 4543 7020 An insecticide. SGTC_691 1548-0686 185 µM -1.50748559767656 0.0886663918147443 no 3073 0.065843116377294 4470 46495133 SGTC_600 1495-0418 41.6 µM -1.51112754803145 0.0881469729054818 no 3074 0.0653779786094765 4477 5377768 SGTC_1568 digitonin 820 nM -1.51244298582525 0.08795992242096 no 3075 0.0652106032377262 4476 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_375 3970-0961 9.27 µM -1.51282430630465 0.0879057554083658 no 3076 0.0651621465008912 4469 2898222 SGTC_1932 st074806 40.9 µM -1.51294349140885 0.0878888301312005 no 3077 0.0651470066499293 4530 17251235 SGTC_314 1671-0008 2.74 µM -1.51497652379573 0.0876004968051775 no 3078 0.0648891747089583 4376 3913060 SGTC_1032 k061-1018 98.7 µM -1.51803452002232 0.0871681288885935 no 3079 0.0645028483016996 4550 4005393 SGTC_1249 0481-0015 10.2 µM -1.52788291537032 0.0857865013284287 no 3080 0.0632708053794184 4445 4227577 SGTC_209 4077-0173 175.592 µM -1.52866586450469 0.0856773691137873 no 3081 0.0631736493801225 4484 15993494 SGTC_3205 9113483 49.47 µM -1.5318513676585 0.0852344258764177 no 3082 0.0627795583791221 4501 17018033 SGTC_3312 9133330 71.43 µM -1.5352172189983 0.0847682718534958 no 3083 0.0623652400459793 4518 17617324 SGTC_2584 androsterone 48.74 µM -1.53712802478139 0.0845044866618294 no 3084 0.0621309806995761 4408 2754130 A steroid. SGTC_479 n-linoleoylglycine 10 µM -1.5379853185465 0.084386338268951 no 3085 0.0620261022672293 4547 6433346 An anti-infammatory. SGTC_357 1325-0123 420 µM -1.53961147207224 0.0841625696715851 no 3086 0.0618275437067298 4510 1098503 SGTC_779 1360-0071 233 µM -1.53978205426023 0.084139122363541 no 3087 0.0618067438597732 4541 7566 SGTC_1891 st059073 26.2 µM -1.54330667748671 0.0836557434396517 no 3088 0.0613781921158557 4580 688754 SGTC_3179 9107801 49.47 µM -1.54629773640219 0.0832471784010392 no 3089 0.0610163392033042 4498 4818259 SGTC_3251 9135047 49.47 µM -1.55058743164288 0.0826638466958614 no 3090 0.0605002930064018 4563 17682963 SGTC_1805 st050013 60.3 µM -1.55125006978244 0.0825740132119214 no 3091 0.060420883661482 4472 4037144 SGTC_2034 5197015 53.07 µM -1.55167157404687 0.0825169083638003 no 3092 0.0603704138163967 4517 780676 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.55213509843168 0.0824541450123454 no 3093 0.0603149506855645 4540 390807 SGTC_1232 0279-0259 161 µM -1.55830366744296 0.0816223107090649 no 3094 0.0595806400012339 4517 1560000 SGTC_1024 4507-0395 26 µM -1.55967787907277 0.081437862417167 no 3095 0.0594180110961551 4559 4201836 SGTC_1347 1493-0251 600 nM -1.56336364681793 0.0809447067814181 no 3096 0.0589835428500183 4568 3986378 SGTC_1188 1403-0014 4.57 µM -1.56934399916336 0.0801493368795908 no 3097 0.0582839026176385 4551 9614867 SGTC_891 0929-0073 133 µM -1.5701285256289 0.0800454369342435 no 3098 0.0581926067208274 4547 5603632 SGTC_2143 5623677 140.463 µM -1.57298866872029 0.0796675118054449 no 3099 0.0578607210017156 4496 5375313 SGTC_1214 0358-0031 63.7 µM -1.57343828233274 0.0796082250755702 no 3100 0.0578086842759324 4542 4301366 SGTC_1831 st055328 12 µM -1.574660615549 0.0794472151119016 no 3101 0.0576674016238422 4519 1103068 SGTC_2172 5754775 163.918 µM -1.57619457187206 0.0792455059369006 no 3102 0.0574904845577675 4511 2263357 SGTC_2495 cafestol 54.53 µM -1.57657223248373 0.0791959045939484 no 3103 0.0574469930758961 4516 16667697 An anti-infammatory. SGTC_723 4182-0001 115 µM -1.57702933809355 0.0791359005202101 no 3104 0.0573943873180034 4536 744821 YLR208W SEC13 SGTC_1144 3486-0183 12.5 µM -1.57783124804153 0.0790307172985854 no 3105 0.0573021915103704 4538 6744069 SGTC_3001 9076041 71.4286 µM -1.5779594503721 0.0790139113489787 no 3106 0.0572874628640789 4538 16004211 SGTC_899 1083-0020 478 µM -1.58402663662004 0.0782216598376128 no 3107 0.0565938288314197 4579 767123 SGTC_358 0075-0058 9.45 µM -1.58571338154664 0.0780024790503691 no 3108 0.0564021711167682 4494 1069125 SGTC_2270 7924575 90.91 µM -1.586922435903 0.0778456577713858 no 3109 0.0562651064116089 4511 1262135 SGTC_11 0438-0307 1.3 µM -1.58954341195168 0.0775065238869329 no 3110 0.0559688805950356 4535 4011476 SGTC_404 fumagillin 50 µM -1.59298086675215 0.0770634461263865 no 3111 0.0555822416820953 4539 12015870 A methionine aminopeptidase binder. SGTC_2749 bexarotene 57.39 µM -1.59302564997243 0.0770576864308347 no 3112 0.0555772184915518 4534 82146 An retinoic acid receptor inhibitor. SGTC_455 paf C-16 10 µM -1.59317608667546 0.0770383407398952 no 3113 0.0555603471115089 4513 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_650 1328-0195 38 µM -1.59614944258411 0.0766567334837629 no 3114 0.0552277160680246 4556 2780821 SGTC_190 3970-0790 3.722 µM -1.59684402225783 0.076567797030385 no 3115 0.0551502401257266 4510 2832352 SGTC_3033 9090887 49.47 µM -1.6015174106898 0.0759714390990356 no 3116 0.0546311834578156 4563 19325384 SGTC_2353 9059630 146.67 µM -1.60606536990913 0.0753944887709059 no 3117 0.054129773874818 4585 4779114 SGTC_3237 9133362 49.47 µM -1.61121407430793 0.0747453655053718 no 3118 0.0535665356171167 4530 43845137 SGTC_812 4251-0442 148 µM -1.61183147849238 0.0746678134493312 no 3119 0.0534993081062056 4572 5723007 SGTC_2811 7967822 32.47 µM -1.6130863452138 0.074510379067438 no 3120 0.0533628750111405 4568 2232244 SGTC_926 2268-1401 59.4 µM -1.61642977631771 0.0740921523953678 no 3121 0.05300071242159 4528 2931578 SGTC_1256 0570-0116 285 µM -1.61942691458493 0.0737187696130292 no 3122 0.0526777198876478 4543 410638 SGTC_1815 st051655 58.2 µM -1.62038495850308 0.0735997205956159 no 3123 0.0525748044633313 4514 5984156 SGTC_3156 9099931 49.47 µM -1.62834286171617 0.0726165255220613 no 3124 0.0517261029391615 4596 18111053 SGTC_1239 0337-0584 35.4 µM -1.62883741155412 0.0725557577355757 no 3125 0.0516737212808628 4597 914301 YML130C ERO1 SGTC_3041 9091929 49.47 µM -1.62956263809059 0.0724667160121455 no 3126 0.0515969831127833 4531 25236887 SGTC_3032 9089427 49.47 µM -1.63853785641429 0.0713716759466371 no 3127 0.0506547718631319 4532 17173707 SGTC_3038 9091290 49.47 µM -1.64310152497479 0.0708197692067353 no 3128 0.050180964707329 4550 25236843 SGTC_342 k048-0088 23.3 µM -1.65118707494578 0.0698500028961706 no 3129 0.0493501907424531 4573 6820570 SGTC_1348 1493-0373 93.8 µM -1.65336875391537 0.069590095069525 no 3130 0.0491279190028649 4580 3010129 SGTC_1205 4161-2785 76 µM -1.65713840036331 0.0691427651462066 no 3131 0.0487457485234297 4567 3498106 SGTC_321 4534-3890 65.3 µM -1.65971779838479 0.0688379565829631 no 3132 0.0484856185517145 4578 699746 SGTC_222 nsc-310342 10.666 µM -1.66104920103304 0.0686810300664925 no 3133 0.0483517828151119 4591 432556 SGTC_3166 9102297 49.47 µM -1.66273318253166 0.0684829419597465 no 3134 0.0481829284300782 4585 25237072 SGTC_940 3232-1287 54.8 µM -1.68280792707175 0.0661553484398212 no 3135 0.04620613998663 4565 1585493 YIL048W NEO1 SGTC_3326 9140064 16.379 µM -1.68448046940893 0.0659642229271992 no 3136 0.0460444254125487 4532 1868434 SGTC_3269 9137823 49.47 µM -1.69388004912023 0.0648980586728183 no 3137 0.0451440394028568 4538 17682936 SGTC_381 3461-2219 42.7 µM -1.69724007206807 0.0645202045933412 no 3138 0.0448256409891511 4570 2883159 SGTC_2384 9036245 200 µM -1.69983253202663 0.0642298371942478 no 3139 0.044581215209075 4558 6462766 SGTC_3334 9142812 21.919 µM -1.70158202889212 0.0640344602167235 no 3140 0.0444168743629069 4577 45283678 SGTC_875 0709-0210 25.7 µM -1.70272443288405 0.0639071305914263 no 3141 0.0443098251304381 4571 6251364 SGTC_2132 5317594 122.667 µM -1.70437407177808 0.06372361333381 no 3142 0.0441556123491001 4526 794577 SGTC_749 1000-0129 128 µM -1.70803861730497 0.0633174109869628 no 3143 0.0438145886089299 4610 708470 SGTC_2572 astragaloside iv 100 µM -1.71138817842956 0.062947889564063 no 3144 0.0435047390075092 4556 45006101 An anti-inflammatory agent. SGTC_3297 9117502 71.43 µM -1.71332502660801 0.0627349855665862 no 3145 0.0433263803447488 4605 7453720 SGTC_3 0833-0587 95.581 µM -1.7133420857088 0.0627331128766909 no 3146 0.0433248120492483 4493 5382644 SGTC_2393 9031399 185.94 µM -1.71549670445204 0.0624969362203023 no 3147 0.0431270995442852 4570 1526623 YDL150W RPC53 SGTC_1883 5-benzylidenerhodanine 20 µM -1.71687339118465 0.062346395248452 no 3148 0.043001153822563 4578 1273210 SGTC_476 mead acid 10 µM -1.7192937787704 0.0620824111903447 no 3149 0.0427804460994276 4659 5312531 An omega 9 fatty acid. SGTC_1150 3909-7983 10.9 µM -1.72060531677787 0.0619397306226195 no 3150 0.0426612340109684 4604 23965914 SGTC_2073 5212005 126 µM -1.72514046603707 0.0614483291598863 no 3151 0.0422510807371821 4537 691789 SGTC_2540 epiandrosterone 100 µM -1.72634378777177 0.0613184569824301 no 3152 0.0421427910672411 4628 441302 A steroid. SGTC_1507 4075-3230 155 µM -1.730919287558 0.0608265893108898 no 3153 0.0417330805236207 4567 659771 SGTC_1120 ficusin 1.78878 µM -1.73208343907614 0.0607019363213173 no 3154 0.0416293536858185 4588 6199 A DNA cross-linker. SGTC_46 0329-0187a 2.197 µM -1.73438483542717 0.0604560993956497 no 3155 0.0414249119655007 4597 46494817 SGTC_382 3229-0966 23.2 µM -1.73441622150073 0.0604527521038842 no 3156 0.0414221294561974 4620 5722370 SGTC_2462 5162487 171.77 µM -1.73729217884561 0.060146649263368 no 3157 0.0411678056848083 4578 2259986 SGTC_865 0488-0499 301 µM -1.7414435212435 0.0597069422725884 no 3158 0.0408029325590197 4548 9634651 SGTC_1454 4239-0054 42.6 µM -1.74145512952182 0.0597057162735029 no 3159 0.0408019159657735 4652 1340767 SGTC_2115 tiliquinol 12.7705 µM -1.7504811577561 0.0587583951246858 no 3160 0.0400176613368992 4579 71208 A bioactive hydroxyquinoline. SGTC_86 0417-1630 471.922 µM -1.75799850318427 0.0579784553704837 no 3161 0.0393738820019629 4621 3634867 SGTC_752 1896-0090 130 µM -1.76650852344959 0.057105368174825 no 3162 0.0386552864386596 4639 772567 SGTC_2690 usnic acid 100 µM -1.76859348991993 0.0568930470238515 no 3163 0.0384808689782182 4610 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3302 9125395 16.351 µM -1.76988343468912 0.056761997969323 no 3164 0.038373280460638 4576 17599668 SGTC_2216 7189485 200 µM -1.77177236132671 0.0565705258385459 no 3165 0.0382161761329462 4642 731273 SGTC_1124 fisetin 1.16336 µM -1.77636531598561 0.0561070813959592 no 3166 0.0378363619865802 4614 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_610 4215-0184 155 µM -1.78771986641792 0.0549742170855198 no 3167 0.0369106074525288 4634 5605015 SGTC_1009 4106-0057 9.87 µM -1.79092840741631 0.0546573922355055 no 3168 0.0366523921938845 4611 2928005 SGTC_683 panaxydol 45 µM -1.79295791185293 0.0544577369724401 no 3169 0.0364898270795807 4637 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_862 0452-0056 10.2 µM -1.79691605935416 0.0540700087523265 no 3170 0.036174473363165 4591 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_603 3794-0023 45.9 µM -1.7970147340007 0.0540603708683072 no 3171 0.0361666403505506 4667 3802260 SGTC_152 4469-0003 551.229 µM -1.79746929459432 0.0540159899680755 no 3172 0.0361305742536139 4608 697280 SGTC_213 1246-0773 967 nM -1.80246074637533 0.0535305458950956 no 3173 0.0357364726161859 4648 6251622 SGTC_1308 1187-1617 41.4 µM -1.80457082573098 0.0533263722266328 no 3174 0.0355709333996759 4652 2882570 SGTC_1406 3909-7906 11.9 µM -1.80465047427428 0.0533186774489305 no 3175 0.0355646971722784 4655 X1406 SGTC_67 0335-0847 266 µM -1.80895530011645 0.0529040994528587 no 3176 0.0352289740296535 4609 4552207 YOR254C SEC63 SGTC_2464 5717415 7.67 µM -1.81738725314841 0.0520994686126522 no 3177 0.0345789190750338 4597 5285744 SGTC_1339 1486-1321 22.7 µM -1.8179445388352 0.0520466332161111 no 3178 0.0345363049891574 4682 3469382 SGTC_1548 st061468 90.8 µM -1.81801244697322 0.052040197860844 no 3179 0.0345311151928605 4678 390799 SGTC_1373 2887-0003 58.5 µM -1.81848622465914 0.0519953176235909 no 3180 0.0344949251377855 4596 776948 SGTC_626 0214-0009 33 µM -1.82169283348052 0.0516923683488499 no 3181 0.0342508029849297 4661 3437874 SGTC_810 3825-7150 143 µM -1.82477148840038 0.0514028296577633 no 3182 0.0340177600528217 4638 22330411 YGL099W LSG1 SGTC_1152 3909-8331 15.9 µM -1.83121850699486 0.0508006853964857 no 3183 0.0335339677270276 4649 16001939 SGTC_2974 9094440 9.66 µM -1.83411061792816 0.0505323967383073 no 3184 0.0333187878037128 4603 25236134 SGTC_3024 9090631 49.47 µM -1.83785582813318 0.05018664839185 no 3185 0.0330418262562656 4641 25236383 SGTC_1077 5-fluorocytosine 377 nM -1.84062689173273 0.0499320466671975 no 3186 0.0328381270685509 4667 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2244 6635614 200 µM -1.84362175397792 0.0496580419699339 no 3187 0.0326191417113707 4605 836499 SGTC_606 k015-0008 38.6 µM -1.84663905703799 0.0493831987577862 no 3188 0.0323997348200561 4693 1970475 SGTC_282 k297-0036 65.7 µM -1.8489381876428 0.0491745895006782 no 3189 0.032233369360065 4630 5061378 SGTC_3154 9100113 49.47 µM -1.85312064795524 0.0487969033897247 no 3190 0.0319325339735947 4616 25237525 SGTC_873 0591-4978 488 µM -1.86113896482938 0.0480793151946406 no 3191 0.031362277461364 4658 3305145 SGTC_3093 9117344 49.47 µM -1.87556752708927 0.0468093408282547 no 3192 0.0303573444555556 4670 24824913 SGTC_2415 st077333 57.7 µM -1.87910323619492 0.0465022754174675 no 3193 0.0301151991776403 4622 2766255 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.87945992814803 0.0464713878093061 no 3194 0.0300908600710732 4666 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2107 5363541 170.161 µM -1.88279075074921 0.0461837506710174 no 3195 0.029864365506128 4598 244052 SGTC_857 0438-0306 1.35 µM -1.88366738017548 0.0461082864462157 no 3196 0.0298049906969861 4664 4686136 SGTC_1784 st039334 36.3 µM -1.89003999222267 0.045562675801978 no 3197 0.0293763058179301 4656 3496984 SGTC_2337 9009472 200 µM -1.89123464594426 0.0454609719972454 no 3198 0.0292965141941824 4604 5742383 SGTC_3332 9141069 11.198 µM -1.8932712367829 0.045288012991524 no 3199 0.0291609040954587 4599 17332883 SGTC_3194 9111903 49.47 µM -1.89327956052646 0.0452873071790699 no 3200 0.0291603509157169 4629 17087251 SGTC_2043 5101342 149 µM -1.89428885419765 0.0452017896149344 no 3201 0.0290933398145797 4670 678451 SGTC_712 r015-0009 80.6 µM -1.89761256289174 0.044921089496359 no 3202 0.0288735691362563 4682 6813872 YLR060W FRS1 SGTC_567 1080-0542 68.4 µM -1.90125710388429 0.0446149085806062 no 3203 0.0286341723723548 4572 5950415 SGTC_2136 5328288 199.296 µM -1.91190648691724 0.0437298676317879 no 3204 0.0279440947514404 4629 262395 SGTC_1688 st021091 57.6 µM -1.91812567851388 0.0432195944853592 no 3205 0.0275475385893165 4710 3656366 SGTC_2936 9038235 15.59 µM -1.92295470762239 0.0428267071468223 no 3206 0.0272428691217245 4591 4749415 SGTC_276 colchicine 750 µM -1.93134057256434 0.0421512999629572 no 3207 0.0267204745285997 4676 2833 A microtubule depolymerizer. SGTC_2580 diallyl disulphide 81.36 µM -1.93200386096929 0.0420982479017757 no 3208 0.0266795146656052 4630 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1380 2291-0730 164 µM -1.93496178787494 0.0418623203582878 no 3209 0.0264974924977352 4666 2999191 SGTC_2678 equilin 100 µM -1.93691486805109 0.0417071281630187 no 3210 0.0263778753410769 4677 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_108 0509-0257 621.132 µM -1.94828853124779 0.0408126092395447 no 3211 0.0256902243348009 4654 536624 SGTC_2048 5246248 200 µM -1.95058584450887 0.0406338327684592 no 3212 0.0255531662271157 4688 677046 SGTC_2871 9038510 12.99 µM -1.95145669049286 0.0405662300588077 no 3213 0.0255013716892592 4629 4945164 SGTC_188 3229-0966 278.469 µM -1.96013594880848 0.0398974471091737 no 3214 0.0249899512299103 4703 5722370 SGTC_1162 k048-0130 20.1 µM -1.96037064779381 0.03987948750452 no 3215 0.0249762420077579 4678 6797406 SGTC_1226 3909-7979 35.4 µM -1.96702904310693 0.0393727063583543 no 3216 0.0245899312985592 4660 6615510 SGTC_2309 7664088 163.95 µM -1.96747375738945 0.0393390459654805 no 3217 0.0245643092188405 4645 704922 SGTC_163 TUB2.036 7.546 µM -1.97682933892877 0.0386363341188374 no 3218 0.0240304620806225 4621 15992207 YJR013W GPI14 SGTC_684 1140-0066 328 µM -1.98276721898205 0.0381956608549892 no 3219 0.0236967186257806 4687 6813534 SGTC_107 0358-0022 2.6945 µM -1.98619636711104 0.0379430430692166 no 3220 0.0235057620475047 4703 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.99175515881938 0.037536436419791 no 3221 0.0231989642087965 4642 6857784 SGTC_1656 st012921 11 µM -1.99444704732902 0.0373408164944247 no 3222 0.0230516106832574 4606 6732821 SGTC_2158 5657123 3.6195 µM -1.99515509625473 0.0372895010409262 no 3223 0.0230129833915211 4690 2858827 SGTC_2098 5376439 882.5 nM -2.00226257898867 0.0367775753551074 no 3224 0.0226282492031986 4704 2844116 SGTC_3019 9081971 49.47 µM -2.00792927613527 0.03637355452087 no 3225 0.0223254038221103 4664 16451803 SGTC_1315 1237-0019 3.69 µM -2.01031871208412 0.0362042862242272 no 3226 0.0221987338334814 4682 825140 SGTC_3150 9097574 49.47 µM -2.01239269803043 0.0360578878248223 no 3227 0.0220892788079499 4698 17217476 SGTC_320 4092-0846 5.34 µM -2.02128512639503 0.0354356755535802 no 3228 0.0216251289716452 4648 1359356 SGTC_178 4092-0806 87.505 µM -2.02446266518942 0.0352154862234431 no 3229 0.0214612848364858 4572 2169044 SGTC_2273 7815444 169.05 µM -2.02711526399489 0.0350325336308421 no 3230 0.0213253131016599 4625 2824616 SGTC_3034 9090421 49.47 µM -2.03435601749077 0.0345370986271024 no 3231 0.0209578564990099 4673 17173761 SGTC_2918 7977171 22.06 µM -2.03621672151227 0.0344107172726612 no 3232 0.0208642989430708 4683 2236483 SGTC_312 4092-0653 6.84 µM -2.0374003837698 0.034330519382061 no 3233 0.0208049677238528 4592 1148278 SGTC_1296 1068-0102 11.9 µM -2.04111286493335 0.0340799797093806 no 3234 0.020619804967942 4700 767053 SGTC_2606 farnesol 9.78 µM -2.04235217145362 0.0339966795981495 no 3235 0.0205583052200209 4660 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_759 3486-0358 89.3 µM -2.04340763553082 0.0339258685692286 no 3236 0.0205060511231474 4677 875103 SGTC_2769 toremifene 3.73 µM -2.04401875618027 0.0338849240024679 no 3237 0.020475847131037 4685 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2218 6965428 192.983 µM -2.04655892506891 0.0337151702267194 no 3238 0.020350705649291 4635 675684 SGTC_2677 mitomycin C 100 µM -2.0515881519293 0.0333811424536382 no 3239 0.0201048523041141 4745 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_548 1436-0017 110 µM -2.0578050845499 0.032972001615157 no 3240 0.0198044238984174 4718 9677137 SGTC_3288 9119690 36.221 µM -2.06518527122237 0.0324916803350341 no 3241 0.0194527367950459 4690 17595618 YKL019W RAM2 SGTC_936 3005-4620 401 µM -2.06890728140242 0.0322516407497493 no 3242 0.0192773940899158 4696 777207 SGTC_3048 9093155 49.47 µM -2.07135545251191 0.0320945528832459 no 3243 0.0191627953409265 4710 25236002 SGTC_3139 9095020 49.47 µM -2.07583381713366 0.0318088316248029 no 3244 0.0189546617602252 4623 25236292 SGTC_1640 st009078 66.4 µM -2.07648161440632 0.0317676764190659 no 3245 0.0189247149177974 4699 690618 SGTC_2651 TUB2.036 5 µM -2.08765866470215 0.0310644880584062 no 3246 0.0184143180130892 4578 15992207 YFL037W TUB2 SGTC_252 miconazole 1.30953 nM -2.09062622175361 0.0308799673193699 no 3247 0.0182807916440768 4635 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2702 st077768 96.8 µM -2.09354119619149 0.0306996002896015 no 3248 0.0181504352921147 4686 6484119 SGTC_114 0364-0001 490.298 µM -2.0968571871386 0.0304954814466011 no 3249 0.0180031097103311 4693 4003655 SGTC_2558 carylophyllene oxide 100 µM -2.10116632560704 0.0302319095098307 no 3250 0.0178131841520268 4749 6708694 An oxygenated terpenoid and antifungal agent. SGTC_739 1486-1183 203 µM -2.117306821299 0.029261390050434 no 3251 0.0171169081788849 4707 4346692 SGTC_2316 5844804 197.44 µM -2.11752755871594 0.029248298737673 no 3252 0.0171075494682149 4682 776813 SGTC_2973 9094665 17.96 µM -2.11800909470487 0.0292197570789969 no 3253 0.017087148729138 4667 25237061 YIL048W NEO1 SGTC_1332 1480-0653 17.5 µM -2.12540598546548 0.028784227183592 no 3254 0.0167763756396109 4714 5749438 SGTC_966 1300-0360 30.2 µM -2.12935254322015 0.0285540700747203 no 3255 0.0166125518312304 4705 70588 SGTC_1753 st043925 64 µM -2.13757489207914 0.0280794705618185 no 3256 0.0162756306730899 4715 670181 SGTC_1 0258-0098 57.368 µM -2.13892448956768 0.0280022019627335 no 3257 0.0162208921601113 4633 6790032 YDR047W HEM12 SGTC_3210 9128157 49.47 µM -2.13915980266547 0.027988747711397 no 3258 0.0162113642272834 4643 17590849 SGTC_2995 9067767 71.4286 µM -2.14334603221234 0.0277502944791194 no 3259 0.0160426615609547 4701 11673567 SGTC_2325 6158266 200 µM -2.14364054473469 0.0277335825818378 no 3260 0.0160308497345904 4692 3623240 SGTC_2553 4-methylesculetin 85.09 µM -2.1447505779317 0.0276706699175106 no 3261 0.0159863973080879 4692 5319502 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.16108549145457 0.0267585384644928 no 3262 0.0153443680487114 4709 6708561 SGTC_1991 st073000 8.92 µM -2.17761367831032 0.0258613090693576 no 3263 0.0147174051686984 4726 4301969 YIL048W NEO1 SGTC_3318 9139014 38.6185 µM -2.17766833819215 0.0258583841555634 no 3264 0.0147153688750725 4705 16643984 SGTC_2350 9023895 38.85 µM -2.18499533911219 0.0254688056104035 no 3265 0.014444594167445 4691 2997209 SGTC_539 4859-0462 2.54 µM -2.20887726491141 0.0242329621806658 no 3266 0.013591589474588 4710 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3014 9081533 49.47 µM -2.21422269201732 0.0239633549344013 no 3267 0.0134067318053642 4725 21367265 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.21426616206875 0.023961172811133 no 3268 0.013405237450621 4697 17037758 SGTC_1922 5578187 25 µM -2.21595653257098 0.0238764484691658 no 3269 0.0133472396083644 4690 1350412 SGTC_1513 0337-0559 19 µM -2.22545246824432 0.0234051626670088 no 3270 0.0130254393101273 4705 775073 SGTC_2987 9018338 71.43 µM -2.23168703700095 0.0231000155667728 no 3271 0.0128178272982087 4720 5055682 SGTC_842 0271-0008 11.1 µM -2.23930394781604 0.022731763689536 no 3272 0.0125680730958968 4731 1221709 SGTC_623 k072-0108 16.9 µM -2.24406570086366 0.0225040718459478 no 3273 0.0124140872004055 4724 5382803 SGTC_969 1313-0238 134 µM -2.28340757031712 0.0206954354114101 no 3274 0.0112031858774664 4742 5212874 SGTC_2532 xanthone 78.9 µM -2.28750590321702 0.0205143104266591 no 3275 0.0110831556346055 4739 7020 An insecticide. SGTC_12 0849-0099 9.267 µM -2.29247503346256 0.0202965038766771 no 3276 0.0109391233081591 4736 6071388 SGTC_32 0928-0142 34.1 µM -2.30030718729789 0.0199571866453228 no 3277 0.0107154113889193 4753 2244242 SGTC_193 1273-0060 1.558 µM -2.32895723181339 0.0187566747420494 no 3278 0.00993066575621461 4666 2847393 YHR072W ERG7 SGTC_1322 1348-1070 12 µM -2.33996976557314 0.0183118582463223 no 3279 0.0096426505223332 4735 6758089 SGTC_1178 0988-0033 191 µM -2.38896603234669 0.0164401689847808 no 3280 0.00844793220488029 4764 5392207 SGTC_2916 7875993 68.79 µM -2.38928407778054 0.0164285756050385 no 3281 0.00844062181601557 4692 1299250 SGTC_116 0155-0182 31.788 µM -2.39161453899024 0.0163438390901707 no 3282 0.0083872245227557 4659 771486 SGTC_1177 0983-0204 23.6 µM -2.40064810175201 0.0160189033780944 no 3283 0.00818303327324881 4763 766818 SGTC_1930 st074634 34.3 µM -2.41419782855927 0.0155419097328881 no 3284 0.0078849487295767 4703 684253 YOR116C RPO31 SGTC_2963 9082507 9 µM -2.42695090845225 0.0151041484861526 no 3285 0.0076131580144488 4725 16459611 SGTC_3309 9129340 25.759 µM -2.43064625103253 0.0149792992870744 no 3286 0.00753596094255863 4746 17158987 SGTC_462 ag-879 158 µM -2.44144517156953 0.0146195233901766 no 3287 0.00731430473950884 4755 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3176 9106582 49.47 µM -2.44182483452014 0.0146070110519829 no 3288 0.00730661755464021 4782 17018027 SGTC_3173 9105693 49.47 µM -2.44484526067882 0.0145077964297613 no 3289 0.00724571509932228 4741 17096658 SGTC_838 0109-0203 71.4 µM -2.44586052264038 0.0144745777293793 no 3290 0.00722534458973104 4763 759422 SGTC_628 1636-0253 16 µM -2.45003000848918 0.0143388406152989 no 3291 0.00714221546811937 4770 4456143 SGTC_1141 3253-0389 52.6 µM -2.48237426383792 0.0133226238429545 no 3292 0.00652550590350339 4755 5402031 SGTC_2642 cholecalciferol 100 µM -2.50498895080071 0.0126496014905244 no 3293 0.0061227609373359 4766 9821465 A vitamin D precursor, similar to steriods. SGTC_1521 st012942 49.4 µM -2.50961868188832 0.0125155071673607 no 3294 0.00604307970816803 4703 24207259 SGTC_710 3448-4187 58 µM -2.52698855486887 0.0120233228917928 no 3295 0.00575226259032896 4738 3946412 SGTC_2126 5251174 33.877 µM -2.5380346160313 0.011719133279038 no 3296 0.00557384787327306 4736 790722 SGTC_270 tamoxifen 5.46 µM -2.54639634602865 0.0114933290255472 no 3297 0.00544207652274483 4757 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.55428550987182 0.0112837605442843 no 3298 0.00532029827518894 4735 521171 SGTC_304 1310-0298 97 µM -2.55773885668403 0.0111930756666344 no 3299 0.00526775883096788 4582 1550234 SGTC_3278 9139605 49.47 µM -2.56514127286199 0.0110008207006462 no 3300 0.00515669020113603 4749 7958859 SGTC_2949 9072542 2.23 µM -2.58515131250398 0.0104954330823006 no 3301 0.00486681351629315 4732 16457352 SGTC_2362 9071156 126 µM -2.59061113197912 0.0103610989138783 no 3302 0.00479028411957769 4754 653133 SGTC_2402 5553605 200 µM -2.60222127979172 0.0100804150709557 no 3303 0.00463110343123175 4764 6758546 SGTC_36 0335-0881 14.2 µM -2.60454581325449 0.0100250219282506 no 3304 0.00459980604900415 4729 23828853 SGTC_2794 7785382 27.27 µM -2.62839611581007 0.00947184706208639 no 3305 0.00428942769692319 4758 2205081 SGTC_3214 9129694 49.47 µM -2.64051813140517 0.00920106457340531 no 3306 0.00413896815586211 4750 17158655 SGTC_2602 kawain 100 µM -2.64198672943413 0.00916872356555701 no 3307 0.00412106426051826 4753 5369129 SGTC_2217 6934799 96.0675 µM -2.64911824285332 0.00901308651570834 no 3308 0.00403510452866882 4782 675606 SGTC_2196 6573537 42.6665 µM -2.65090806633903 0.00897439082441147 no 3309 0.00401378444137917 4774 2903087 SGTC_1751 st044839 27.194 µM -2.65132780002261 0.00896533734482262 no 3310 0.00400879926499055 4784 5291326 SGTC_201 4262-0159 12.803 µM -2.69237740253201 0.00811767924135165 no 3311 0.00354723067211117 4787 1341029 SGTC_335 4077-0256 27.6 µM -2.69260707164476 0.00811314193291476 no 3312 0.00354478836314366 4701 3121989 SGTC_1795 st049545 62.3 µM -2.70989918833831 0.00777785884623924 no 3313 0.00336518306158902 4777 5291882 SGTC_2985 9022375 71.43 µM -2.71069953946449 0.00776264015333462 no 3314 0.00335707182077647 4755 4939335 SGTC_778 3456-2434 196 µM -2.73124131621044 0.00738090244655235 no 3315 0.00315481263007214 4746 5539063 SGTC_571 k831-0106 44.2 µM -2.75510340476483 0.00695831482702294 no 3316 0.00293367944034842 4755 4783639 SGTC_2948 9070189 9.45 µM -2.76769291225419 0.00674408520880044 no 3317 0.00282273113982757 4730 6473636 YDL196W YDL196W SGTC_1763 st044482 94.5 µM -2.77991660044618 0.00654167841622121 no 3318 0.00271864303196701 4773 88505 SGTC_81 0411-0046 9.971 µM -2.78261742815459 0.00649768802463001 no 3319 0.00269611739739032 4794 12925265 SGTC_2219 9098279 200 µM -2.80580299819087 0.00613068560636051 no 3320 0.0025095683925412 4785 902349 SGTC_2223 6903751 107.57 µM -2.810433411169 0.00605963127560301 no 3321 0.00247374127673085 4774 5598863 SGTC_1490 4089-0339 670 nM -2.84336867961631 0.00557495126946148 no 3322 0.00223197003181229 4797 742542 SGTC_99 0109-0120 622.8 µM -2.91416131600215 0.00464800668886352 no 3323 0.00178322780607464 4788 759414 SGTC_3087 9117406 49.47 µM -2.92916092846459 0.00447024322669785 no 3324 0.00169939202487888 4781 42546093 SGTC_3168 9103419 49.47 µM -2.93602994171085 0.00439088343567423 no 3325 0.00166221116319581 4796 16649256 SGTC_2306 7482397 179.52 µM -2.93677663380198 0.00438233298613386 no 3326 0.00165821440965846 4765 891448 SGTC_617 3770-0098 35 µM -2.9397280819703 0.00434868108908907 no 3327 0.00164250198134575 4758 5962639 SGTC_2544 sphondin 68.51 µM -2.96950304156388 0.00402189156515104 no 3328 0.00149140929754073 4771 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3157 9099274 49.47 µM -2.97472057172372 0.00396694726130649 no 3329 0.00146627771117555 4785 17217662 SGTC_2281 7943571 200 µM -2.9794582432145 0.00391763958510588 no 3330 0.00144379291854001 4792 1244024 SGTC_340 k038-0059 454 µM -3.06033332184322 0.00315648626244834 no 3331 0.00110545391656228 4797 23733424 SGTC_985 1493-0307 8.71 µM -3.08758520999089 0.00293172846763987 no 3332 0.00100894955525223 4795 3278274 SGTC_2976 9009005 19.48 µM -3.11598635980729 0.0027129404891815 no 3333 0.000916653761515328 4782 2993148 SGTC_2250 alverine citrate 130 µM -3.12815733584892 0.00262377935321021 no 3334 0.000879529952065502 4723 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1989 st071868 50.2 µM -3.12904396072357 0.0026173888095207 no 3335 0.000876880341362836 4802 16414057 SGTC_599 1935-0052 86.5 µM -3.21331682275331 0.00207045084697484 no 3336 0.000656057321595207 4805 9557311 SGTC_2850 9015429 58.44 µM -3.2720915761055 0.00175277588512825 no 3337 0.000533774957491646 4785 6457570 SGTC_2282 7944268 200 µM -3.29746412163348 0.00162988973470545 no 3338 0.000487810691596578 4790 2970414 SGTC_1765 st044815 90.4 µM -3.30080428519613 0.00161431076032167 no 3339 0.000482040542782586 4802 645695 SGTC_690 glyoxal 20.3 µM -3.3300771706851 0.00148347345119718 no 3340 0.000434109587981271 4733 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_58 0957-0393 9 µM -3.37439283154787 0.00130373186859744 no 3341 0.000369893574179525 4527 6997992 SGTC_2763 lisinopril 49.32 µM -3.42940260953563 0.00110837582890901 no 3342 0.000302455741186014 4790 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_266 formosanin C 406 nM -3.52489553676305 0.000831761872543394 yes 3343 0.000211824910499566 4781 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2761 levamisole 97.89 µM -3.55662436777228 0.000754956154523348 yes 3344 0.000187825341924869 4800 26879 An alkaline phosphatase inhibitor. SGTC_2260 7964312 200 µM -3.68984198808097 0.000498561977053902 yes 3345 0.000112196693122061 4806 231951 SGTC_1841 st054148 70 µM -3.73710102652854 0.000428960471709522 yes 3346 9.30770709740688e-05 4809 675442 SGTC_959 1222-0044 107 µM -3.79127986276067 0.000360301487519097 yes 3347 7.49364776544482e-05 4805 6083612 SGTC_2348 9022543 33.42 µM -3.80344969680294 0.000346353852436138 yes 3348 7.13474899227231e-05 4801 3162678 YDL140C RPO21 SGTC_1840 st055363 71 µM -3.87012350292491 0.000278440765375961 yes 3349 5.43901158849477e-05 4806 676033 SGTC_2014 4013930 200 µM -4.00684695235304 0.000176137263033866 yes 3350 3.07673540174185e-05 4803 64556 SGTC_2405 ticlatone 3.52 µM -4.01374013037278 0.000172053502316046 yes 3351 2.98820713688094e-05 4763 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2772 vinpocetine 57.06 µM -4.04183195650185 0.000156309594353939 yes 3352 2.65176174338249e-05 4802 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2913 7966556 36.57 µM -4.63422299156191 1.79929465654684e-05 yes 3353 1.79140315690994e-06 4804 2976516 SGTC_2020 4017018 200 µM -5.52695733110096 4.18809062069779e-07 yes 3354 1.62916082722334e-08 4810 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2015 5119600 184 µM -5.90499672812214 7.09189373137395e-08 yes 3355 1.76326874628446e-09 4809 2828786 SGTC_1715 st032160 10.2275 µM -7.55425502523326 8.4417457481484e-12 yes 3356 2.10632021821959e-14 4810 5289825