SGTCid condition conc unit PUS1|YPL212C.score PUS1|YPL212C.strain.pval PUS1|YPL212C.strain.significant PUS1|YPL212C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_129 0088-0017 176.636 µM 16.3504461755487 1.19217993329264e-60 yes 1 2.15903323736177e-60 4 182446
SGTC_2034 5197015 53.07 µM 8.44309152278071 1.10693238766516e-17 yes 2 1.5452646534131e-17 2 780676
SGTC_318 1488-0629 67.2 µM 8.08743572730704 2.21020301679159e-16 yes 3 3.0466983314757e-16 6 3662576
SGTC_29 0299-0004 12.984 µM 7.45164016532082 3.42075813594607e-14 yes 4 4.60934396111969e-14 8 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2009 4012297 12.05 µM 6.43307339240943 4.81451912535225e-11 yes 5 6.25246157622556e-11 21 45595307
SGTC_1001 4048-4355 44.4 µM 5.74568497955133 3.61455906562693e-09 yes 6 4.57748054262934e-09 12 21824233
SGTC_2744 captopril 92.04 µM 5.20831988069088 7.67400713680619e-08 yes 7 9.52791032529133e-08 3 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2007 4011539 71.82 µM 5.04586879861293 1.82904702480421e-07 yes 8 2.25732571402706e-07 33 45595301
SGTC_2949 9072542 2.23 µM 4.98065134200398 2.57356824207274e-07 yes 9 3.16853107284174e-07 13 16457352
SGTC_697 0508-1955 564 µM 4.79535086163793 6.64026278692948e-07 yes 10 8.11951740697568e-07 15 6243113
SGTC_2006 4011487 200 µM 4.74169526486375 8.68350457292818e-07 yes 11 1.05968625008723e-06 60 45595294
SGTC_2720 fluspirilene 36.88 µM 4.68133323445707 1.17037908992754e-06 yes 12 1.4250760063294e-06 7 3396 An atypical antipsychotic.
SGTC_2835 9006588 71.43 µM 4.13952601838592 1.45810996770313e-05 yes 13 1.74012064868896e-05 33 2345538
SGTC_89 0302-0250 142.109 µM 4.0928669541559 1.78819805961205e-05 yes 14 2.13036107268685e-05 16 4203518 YLR208W SEC13
SGTC_2746 daunorubicin 9.88 µM 4.01816166307611 2.46849832553141e-05 yes 15 2.93269759933939e-05 1 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2920 7982904 15.77 µM 3.98932082031091 2.79170474392827e-05 yes 16 3.31313754438934e-05 23 6456808
SGTC_2310 7668677 200 µM 3.96420160587179 3.10548973372074e-05 yes 17 3.68209988112874e-05 29 2197143
SGTC_2389 9091542 195.52 µM 3.6528087886494 0.000110653598545981 yes 18 0.000129693692668057 45 3626624 YOL127W RPL25
SGTC_2043 5101342 149 µM 3.65044936982654 0.000111684852229431 yes 19 0.000130890954889128 24 678451
SGTC_395 anisomycin 6.25 µM 3.59376079635429 0.000139348652649792 yes 20 0.000162969544385184 15 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2488 5268135 45.7 µM 3.57624500377507 0.00014911856790284 yes 21 0.000174282496359889 63 1270356 YLR208W SEC13
SGTC_259 usnic acid 108.925 µM 3.49324627839334 0.000204771669027684 yes 22 0.000238593101091085 31 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2083 5306046 65.942 µM 3.42273533235696 0.000266727103756566 yes 23 0.000309972040430132 48 539837
SGTC_843 0310-0051 143 µM 3.4025415437736 0.000287454790388513 yes 24 0.000333811022248046 29 2065037
SGTC_1814 st052110 31.539 µM 3.39207802624012 0.000298775707497665 yes 25 0.000346823420749535 21 674163
SGTC_2360 9040895 200 µM 3.35421123123033 0.000343306312844022 yes 26 0.000397957895996287 33 4914414
SGTC_1203 3992-3522 103 µM 3.33896503363251 0.000362918914007409 yes 27 0.000420455742621464 63 5322312
SGTC_2807 7945238 51.95 µM 3.29831141181355 0.000420418999439739 yes 28 0.000486340969791371 56 17148797
SGTC_2198 6589944 200 µM 3.25124434777267 0.000497496692159925 yes 29 0.000574505300128114 28 5290268
SGTC_2860 9025725 38.96 µM 3.24593933831986 0.000506960058639392 yes 30 0.000585318904666293 29 40546248
SGTC_624 k048-0052 28 µM 3.23790205909813 0.000521615262627613 yes 31 0.000602060695771956 37 6835531
SGTC_1384 3089-0840 101 µM 3.23387917831067 0.000529096908554323 yes 32 0.000610605533651789 36 1069836
SGTC_2472 5377652 49.4 µM 3.23262338371104 0.000531452657485404 yes 33 0.000613295769762474 93 1610903
SGTC_612 0302-0167 22.4 µM 3.20119206890156 0.00059367073141009 yes 34 0.000684301354868325 69 235821
SGTC_2336 9001819 198.65 µM 3.1671301566496 0.000668647802895008 yes 35 0.000769756984966377 87 2989602
SGTC_2142 5622915 118.518 µM 3.14069428358751 0.000732757539373406 yes 36 0.000842739363682963 30 5322196
SGTC_853 0419-0306 21 µM 3.11877856942912 0.000790149574935039 yes 37 0.000908011916322192 42 762713
SGTC_544 k015-0020 52.4 µM 3.11479313793932 0.000801020953443874 yes 38 0.000920369761137186 43 3008304
SGTC_1963 st076565 50.3 µM 3.07738517606799 0.000909982407700632 yes 39 0.0010441263689543 43 4914280
SGTC_2821 7996764 71.43 µM 3.06958875980633 0.000934341407307924 yes 40 0.00107176850400329 92 2987135
SGTC_2018 5133068 143 µM 3.05610288307431 0.000977895102912634 yes 41 0.00112117149463887 69 785362
SGTC_2340 7987427 183.45 µM 3.04070479742244 0.00102989887167555 no 42 0.00118012557701766 76 2239331
SGTC_2817 7995342 71.43 µM 3.014517686286 0.001124199683508 no 43 0.00128694101886035 62 18879975
SGTC_2563 tomatine 8.54 µM 2.96698081308764 0.0013158450889304 no 44 0.00150369862959306 114 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3045 9092950 49.47 µM 2.96225764540774 0.00133643298363842 no 45 0.00152696060548661 57 44120432
SGTC_2654 protoveratrine a 100 µM 2.95145087456962 0.00138465070063097 no 46 0.00158142426781984 41 5702278 A heart drug and vasodilator.
SGTC_898 1000-0849 28.3 µM 2.91163898444143 0.00157631004496109 no 47 0.00179768957850114 36 6751807
SGTC_474 dl-dihydrosphingosine 5 µM 2.86283954568813 0.00184409170641803 no 48 0.00209931562615102 91 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3305 9127027 53.8275 µM 2.86217166679889 0.00184802762752695 no 49 0.00210374473889814 65 41905295
SGTC_2229 7354935 190 µM 2.81501888468886 0.00214599112872178 no 50 0.00243871838190428 38 318112
SGTC_2922 7999257 32.47 µM 2.77530561613259 0.00243003464464901 no 51 0.00275749280798104 54 2988377
SGTC_1467 k284-1082 293 µM 2.77335635200284 0.00244481461869223 no 52 0.00277406644884298 72 3334705
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.7400313034591 0.00271039681223461 no 53 0.00307166664908591 84 75037 A free radical scavenger.
SGTC_2276 7947513 42.08 µM 2.70151649605915 0.00304958668004006 no 54 0.0034512028120185 89 2105100
SGTC_2361 9034121 116 µM 2.66210969934426 0.00343575036152244 no 55 0.00388262833544261 85 6496917
SGTC_1166 k206-0078 225 µM 2.6500282552937 0.00356264478637359 no 56 0.00402425197141743 96 5404595
SGTC_2483 5729050 27.16 µM 2.64939646291689 0.00356939496995546 no 57 0.00403178377547961 113 2865180
SGTC_2721 ifenprodil 61.44 µM 2.64470507257436 0.00361987884805176 no 58 0.00408810730380287 96 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_513 4245-1575 41.7 µM 2.64028611215039 0.00366801619634893 no 59 0.00414180309412682 238 719745
SGTC_2390 9097792 176.6 µM 2.61815909936868 0.00391779838881529 no 60 0.0044202787842076 84 4497149
SGTC_415 dibenzyl ketone 100 µM 2.61466422904972 0.00395861452865641 no 61 0.00446576052720777 83 7593
SGTC_3182 9108849 49.47 µM 2.59973451378362 0.00413729814618815 no 62 0.00466479535964956 81 17133045
SGTC_1040 k898-0338 155 µM 2.5789424524605 0.00439816420432129 no 63 0.00495516474516861 101 20969351
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.54082767429842 0.00491477506582993 no 64 0.00552952058857153 93 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3187 9109394 49.47 µM 2.53605442502228 0.00498314237051144 no 65 0.0056054654595552 126 17098090
SGTC_1107 amlodipine 47 µM 2.49474278184024 0.0056111479651331 no 66 0.00630242322496451 129 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_98 0074-0023 107.663 µM 2.48714539593118 0.00573400513169236 no 67 0.00643863791784336 146 3563821
SGTC_2332 7982454 138.89 µM 2.48156780263177 0.0058257141710209 no 68 0.00654029111261422 180 2981748
SGTC_479 n-linoleoylglycine 10 µM 2.47515150110595 0.00593282120028131 no 69 0.00665898337937111 82 6433346 An anti-infammatory.
SGTC_2515 chrysin 20.77 µM 2.47217001795782 0.00598318251459879 no 70 0.00671478153092539 93 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_559 1550-0661 158 µM 2.47097283998717 0.00600351089076414 no 71 0.00673730260469176 95 5830875
SGTC_357 1325-0123 420 µM 2.44868861428552 0.00639324231840057 no 72 0.00716886698655721 87 1098503
SGTC_2277 7947813 106.88 µM 2.44767634534102 0.00641146590469313 no 73 0.00718903731272435 143 1246798
SGTC_751 0833-0568 350 µM 2.43706941377816 0.00660520128728411 no 74 0.00740341837327357 122 6954252
SGTC_1721 st082152 9.2685 µM 2.43372384542257 0.00666737264555646 no 75 0.0074721959151133 120 5296051
SGTC_303 1348-1668 34.2 µM 2.43253158660242 0.00668965331737908 no 76 0.00749684183763959 84 5380509
SGTC_2581 avocatin a 64 µM 2.41219665747508 0.00707993160431819 no 77 0.00792836306236134 164 6710728 A skin care supplement.
SGTC_785 1270-0111 65.3 µM 2.405109831067 0.0072205921904473 no 78 0.00808380296726249 153 6741994
SGTC_538 2922-0838 53.3 µM 2.40358750803894 0.00725112712465408 no 79 0.00811754041472692 168 777039
SGTC_2089 5281248 129.67 µM 2.40250719666915 0.00727286515354689 no 80 0.00814155708044009 137 2737878
SGTC_1923 st058458 19.1 µM 2.40224399982117 0.00727816989809858 no 81 0.00814741772415588 181 3534982
SGTC_255 tunicamycin 200.472 nM 2.39046608837499 0.00751907335355312 no 82 0.0084135015181626 203 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_577 r071-0003 38.6 µM 2.38078650503594 0.00772228801360752 no 83 0.00863786053058897 214 4568517 YMR134W ERG29
SGTC_2294 7971431 200 µM 2.36551064748884 0.00805283072431472 no 84 0.0090026127753451 114 5741572
SGTC_284 0988-0104 32.6 µM 2.34093959186436 0.00861062296759251 no 85 0.00961763955142438 119 4666532
SGTC_595 3909-8003 73.7 µM 2.33889587769729 0.00865850927051492 no 86 0.00967041145102016 131 699517
SGTC_2790 5423970 71.43 µM 2.33123736362435 0.00884003975355543 no 87 0.00987042348714195 201 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_21 0849-0113 22.993 µM 2.31926475554302 0.00913051239912512 no 88 0.0101903426031033 176 1560156
SGTC_1723 st034307 2.5525 µM 2.31449355883686 0.0092485768079425 no 89 0.010320332083808 155 867466
SGTC_300 r073-0011 5.04 µM 2.31291057380613 0.00928804224376341 no 90 0.0103637781755402 150 2735780
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.29174237176815 0.00983011964352238 no 91 0.0109602569140428 217 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1664 st014217 9.02 µM 2.29012200405766 0.00987273033100709 no 92 0.0110071225721638 139 3982782
SGTC_2044 5102272 200 µM 2.27420348699896 0.0102999871984687 no 93 0.0114768773479294 113 592666
SGTC_752 1896-0090 130 µM 2.27306426485681 0.0103311733114466 no 94 0.0115111537512787 140 772567
SGTC_780 0109-0199 192 µM 2.2568443849901 0.0107842029552227 no 95 0.0120089001025786 173 610414
SGTC_371 0195-0006 7.36 µM 2.25537552504865 0.0108260703950545 no 96 0.0120548838307613 128 3928593
SGTC_1896 st058441 89 µM 2.25011145928405 0.0109772781912497 no 97 0.0122209354197408 141 688759
SGTC_476 mead acid 10 µM 2.22730885262443 0.0116536831976408 no 98 0.0129633196451179 85 5312531 An omega 9 fatty acid.
SGTC_319 1348-1596 45.5 µM 2.22696611955096 0.01166411991138 no 99 0.0129747691069571 165 5380505
SGTC_1757 st041620 31.8375 µM 2.2265437642949 0.0116769923944936 no 100 0.0129888904805803 173 5289815
SGTC_365 0121-0052 13.6 µM 2.20698114971913 0.0122868888870529 no 101 0.0136576881555457 275 3101739
SGTC_3301 9125354 19.7965 µM 2.19412191024121 0.0127026667799272 no 102 0.0141133232602318 141 41905162
SGTC_678 1218-2179 85.9 µM 2.18270353071462 0.013082007265727 no 103 0.0145288248783773 88 6820081 YOR116C RPO31
SGTC_931 2812-0076 566 µM 2.17863507469004 0.0132195153110355 no 104 0.014679394202602 183 3450959
SGTC_327 1273-0057 3.96 µM 2.17860713132077 0.0132204640587878 no 105 0.0146804329820829 170 3108138
SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.17206729370903 0.0134441322397721 no 106 0.0149252937458021 195 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2339 9000433 200 µM 2.17086218671812 0.0134857025160177 no 107 0.0149707957222642 173 2988954
SGTC_533 1222-0222 6.71 µM 2.15857967030293 0.0139157565760231 no 108 0.0154413956805034 199 3982874
SGTC_3140 9094243 49.47 µM 2.14180806704983 0.0145220527652037 no 109 0.0161044650062803 203 19291112
SGTC_1613 st002381 52.1 µM 2.13416650997504 0.0148057511404349 no 110 0.016414576533887 179 551167
SGTC_3008 9078912 71.4286 µM 2.13268410242496 0.0148613351723266 no 111 0.0164753244507625 167 16648731
SGTC_1549 4'-methoxyflavonol 74.6 µM 2.10738657372778 0.0158379082086527 no 112 0.0175420422301946 160 97141
SGTC_2197 6588183 93.1375 µM 2.10488095220285 0.0159375636656938 no 113 0.0176508360737987 142 884136
SGTC_899 1083-0020 478 µM 2.10381277288144 0.0159802112570799 no 114 0.0176973910864085 198 767123
SGTC_1972 st070201 17.4 µM 2.10289674845247 0.0160168618695954 no 115 0.0177373980686693 180 2829099
SGTC_118 0083-0097 135.343 µM 2.10071872934433 0.0161042949694027 no 116 0.0178328321091599 450 5207356
SGTC_1910 st062352 60.4 µM 2.09381513722703 0.0163841364212608 no 117 0.0181382255980829 234 2245730
SGTC_1214 0358-0031 63.7 µM 2.07193869073027 0.0172985762605219 no 118 0.0191355795751509 208 4301366
SGTC_1409 3909-8004 61.9 µM 2.07163571142619 0.0173115408928602 no 119 0.0191497134569014 241 2119279
SGTC_2775 cyproheptadine 69.59 µM 2.05592542024039 0.017995259412057 no 120 0.0198948527245983 185 2913 A selective serotonin reuptake inhibitor.
SGTC_504 lovastatin 124 µM 2.0455796153349 0.0184579781878998 no 121 0.0203988743686932 154 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_453 enantio-paf c16 10 µM 2.03951309650868 0.0187339889713195 no 122 0.0206994227481689 447 13871343 A lipid and platelet activating factor
SGTC_2366 9070441 60.58 µM 2.03890012686936 0.018762071874462 no 123 0.0207299981284872 231 6837235
SGTC_918 glabranin 770.725 nM 2.03334111975917 0.0190183946325382 no 124 0.021009035777376 230 124049 Also referred to as licorice root.
SGTC_753 1322-0200 289 µM 2.0329354574308 0.019037215531852 no 125 0.0210295220892164 203 5403907
SGTC_3286 9117135 37.221 µM 2.02784082166015 0.0192749353035126 no 126 0.0212882482739196 202 3438150
SGTC_2008 4012253 172 µM 2.02665212448311 0.019330762419368 no 127 0.0213490009234992 250 603940
SGTC_705 1124-0212 310 µM 2.02445906032308 0.0194341202142274 no 128 0.0214614701187747 215 9554485
SGTC_2420 aureobasidin a 50 nM 2.02184550952232 0.0195579080693908 no 129 0.0215961572845658 270 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_992 3909-8734 162 µM 2.02124800322104 0.0195863021297341 no 130 0.0216270493910734 195 4288319
SGTC_2558 carylophyllene oxide 100 µM 2.00004710120723 0.0206166878106665 no 131 0.0227475890282544 209 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_441 propafenone 146 µM 1.99599774252845 0.020818625785662 no 132 0.0229670842598967 160 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2555 cholic acid 100 µM 1.9935523183962 0.0209413860813099 no 133 0.0231005002982935 194 6708657 Influences liver metabolism.
SGTC_1433 4060-0023 7.6 µM 1.98625074112701 0.0213115767817172 no 134 0.0235027446163572 209 3840627
SGTC_3083 9117465 49.47 µM 1.98524548297283 0.0213629742874998 no 135 0.0235585831091085 250 16420915
SGTC_1524 corynanthine 62.1 µM 1.98150154942221 0.0215553196062742 no 136 0.0237675278913117 207 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_770 0389-1121 67.2 µM 1.97985449880112 0.0216403995839899 no 137 0.0238599402336329 274 6753108
SGTC_169 k015-0017 16.025 µM 1.97893760717237 0.0216878853257744 no 138 0.0239115157198753 196 1840002
SGTC_1028 k015-0029 4.8 µM 1.97801685156652 0.0217356597433219 no 139 0.0239634028165274 267 4588309
SGTC_1472 k841-0093 193 µM 1.97674393657098 0.0218018527215387 no 140 0.0240352908539758 250 X1472
SGTC_111 0083-0039 52.457 µM 1.96895337450104 0.022210690858902 no 141 0.0244792227488618 101 759313
SGTC_1693 xanthone 101.9 µM 1.96783519264395 0.0222698991031296 no 142 0.0245435017429672 232 7020 An insecticide.
SGTC_1616 st002734 56.1 µM 1.96524634329237 0.0224074910860421 no 143 0.0246928662630286 263 4026101
SGTC_1761 st044296 37 µM 1.9627571473287 0.0225404621302135 no 144 0.0248371996495487 205 1826700
SGTC_273 hydroxyurea 18.1 mM 1.96215847894428 0.0225725416237199 no 145 0.0248720181547701 289 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_427 1354-0053 47.3 µM 1.96072491661281 0.0226495151701161 no 146 0.024955560422999 241 6813657
SGTC_704 1310-0270 142 µM 1.95076379240437 0.0231904996402483 no 147 0.0255425754225341 268 5718033
SGTC_974 1326-0144 138 µM 1.94860600120401 0.0233091109078346 no 148 0.0256712474567824 278 5411856
SGTC_79 0052-0007 94.094 µM 1.94425501441909 0.023549832776745 no 149 0.0259323532729308 237 2801472
SGTC_2380 9035439 200 µM 1.93213656008352 0.0242313435585706 no 150 0.0266713264329141 266 6462575
SGTC_650 1328-0195 38 µM 1.92643705645487 0.0245575517974312 no 151 0.0270249120747629 266 2780821
SGTC_2181 6316240 54.2555 µM 1.92519139508518 0.0246293352417792 no 152 0.0271027091093273 223 12779990
SGTC_2642 cholecalciferol 100 µM 1.91220360890558 0.0253883222240574 no 153 0.0279250417048826 198 9821465 A vitamin D precursor, similar to steriods.
SGTC_1123 mangostin 811.285 nM 1.90791537969277 0.0256431829914414 no 154 0.0282010770765926 287 5281650 An antioxidant.
SGTC_1600 coumarin 106 71.1 µM 1.90724561255989 0.0256831817549504 no 155 0.0282443947160846 261 100336 A hepatotoxic, DNA x-linker.
SGTC_2313 7726885 200 µM 1.90033290141243 0.0260990712239779 no 156 0.0286947231257086 271 726423
SGTC_3159 9100096 49.47 µM 1.89776177312208 0.0262551882713432 no 157 0.0288637354936195 248 25236875
SGTC_2104 5389443 200 µM 1.8853940780164 0.0270170956754854 no 158 0.0296883264821019 285 2244536
SGTC_657 3534-0529 86.7 µM 1.88267584221037 0.027187002263715 no 159 0.0298721556212104 249 1049549
SGTC_2628 lathosterol 100 µM 1.8805623483843 0.0273197239466564 no 160 0.0300157387882469 264 6710616
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.87773751916552 0.0274979589973551 no 161 0.0302085406926634 361 6708739 YPR165W RHO1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.87370520745473 0.0277540599797847 no 162 0.030485533896918 240 2374 Ca(2+)-ATPase inhibitor.
SGTC_2696 st077691 74.316 µM 1.86835961809952 0.0280966310892807 no 163 0.0308559808951303 243 757133
SGTC_936 3005-4620 401 µM 1.86786278423548 0.0281286486488483 no 164 0.0308905997147922 291 777207
SGTC_307 1501-1223 22.3 µM 1.86675762787518 0.0281999773999077 no 165 0.0309677210525817 231 2830329
SGTC_1534 6-azauridine 81.6 µM 1.86554742533203 0.0282782586725182 no 166 0.0310523555545056 300 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1959 st077091 55.8 µM 1.84955398980038 0.0293298821607609 no 167 0.0321889297275326 304 821356 YKL052C ASK1
SGTC_2645 abamectin 100 µM 1.84036819388137 0.029948426236518 no 168 0.0328570998738639 286 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2147 5545932 89.7195 µM 1.83414463857368 0.0303736195540238 no 169 0.0333162633695337 237 797404
SGTC_1883 5-benzylidenerhodanine 20 µM 1.82452334263446 0.0310407812255864 no 170 0.0340364953391758 369 1273210
SGTC_2261 9010538 184.68 µM 1.82330204496797 0.0311263294598207 no 171 0.0341288283835129 222 6457250
SGTC_1102 cgs 12066b 26.1 µM 1.81655385027145 0.0316025434850871 no 172 0.0346427276580643 232 6438352 A 5-HT1B full agonist.
SGTC_1652 st011932 78 µM 1.81478112351554 0.0317286370641232 no 173 0.0347787761983947 248 1551076
SGTC_3091 9116372 49.47 µM 1.81307277644998 0.0318505443702143 no 174 0.0349102986812192 260 17169793
SGTC_2514 salinomycin 42.74 µM 1.81134361836727 0.0319743304909895 no 175 0.0350438388587191 355 23682228 A polyether potassium ionophore.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.80834004840982 0.0321902928848304 no 176 0.0352767962198089 242 61125 An anti-inflammatory.
SGTC_3156 9099931 49.47 µM 1.80649348188538 0.0323236611922543 no 177 0.0354206456844487 256 18111053
SGTC_1475 4092-1048 11.7 µM 1.80606504600581 0.0323546700672513 no 178 0.035454089944768 317 2881759
SGTC_1831 st055328 12 µM 1.80524186261357 0.0324143184476317 no 179 0.0355184213765346 285 1103068
SGTC_2474 5321570 43.32 µM 1.79699737834421 0.0330167382256819 no 180 0.0361680179804514 236 2841384
SGTC_507 nimesulide 162 µM 1.79101730655688 0.0334594472289477 no 181 0.0366452589074735 292 4495 A COX2 inhibitor.
SGTC_3289 9119912 71.43 µM 1.77484424125494 0.0346812816000466 no 182 0.0379618045426269 294 17014829
SGTC_1325 1431-0015 227 µM 1.77326152195377 0.0348027956839533 no 183 0.0380926909203099 269 1103340
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.77217496533813 0.0348864188186991 no 184 0.0381827589700753 325 688667
SGTC_1062 mesoridazine 14.2 µM 1.76434793397036 0.0354936849541489 no 185 0.0388367091687718 312 4078 A neuroleptic.
SGTC_574 1315-0397 40 µM 1.76304117213543 0.0355959104141653 no 186 0.038946772930843 380 6794277
SGTC_2407 paclitaxel 400 µM 1.76089111653143 0.0357646302538835 no 187 0.0391284168910291 350 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1797 st048695 56.8 µM 1.75796667779814 0.0359951690417427 no 188 0.0393765896336854 331 592262 YIL048W NEO1
SGTC_328 k915-0120 63.5 µM 1.75184135874711 0.0364819842964019 no 189 0.0399005451485063 304 6624543
SGTC_3244 9134489 49.47 µM 1.74898653032409 0.03671070798999 no 190 0.0401466738811131 308 16584271
SGTC_2929 9013348 24.6 µM 1.74516785042459 0.0370184860416788 no 191 0.0404778278483421 316 2995952
SGTC_3215 9129942 49.47 µM 1.74220319802672 0.0372588828250973 no 192 0.0407364472992695 247 17682944
SGTC_1237 0330-0133 46.1 µM 1.74116919709692 0.0373430269728377 no 193 0.0408269624371653 289 X1237 YHR072W ERG7
SGTC_3318 9139014 38.6185 µM 1.73075162339489 0.0381994702760476 no 194 0.0417480367655301 284 16643984
SGTC_942 3253-1115 227 µM 1.72969474290115 0.0382872457436076 no 195 0.0418424142323364 316 46497897
SGTC_2540 epiandrosterone 100 µM 1.72257959244458 0.0388824582310315 no 196 0.0424822890362296 432 441302 A steroid.
SGTC_1842 st055362 61.2 µM 1.72029781296352 0.0390749269514604 no 197 0.0426891604024384 349 676032
SGTC_731 3966-0296 387 µM 1.71783341771215 0.0392836698289903 no 198 0.0429135021143097 310 660956
SGTC_2096 5468907 200 µM 1.71667117475357 0.0393824302897627 no 199 0.0430196348839531 294 759785
SGTC_508 roscovitine 141 µM 1.69698955222832 0.041085742675466 no 200 0.0448493178976177 266 160355 A CDKinase inhibitor.
SGTC_2761 levamisole 97.89 µM 1.69556431619527 0.0412113719365863 no 201 0.0449842101896418 308 26879 An alkaline phosphatase inhibitor.
SGTC_2027 5150920 200 µM 1.69554076165883 0.0412134507945526 no 202 0.0449864422625137 303 786715
SGTC_1764 st044502 93.5 µM 1.69150576552863 0.0415708249822759 no 203 0.045370123782529 338 8407
SGTC_2661 dactinomycin 12.96 µM 1.6903896348743 0.0416701212338576 no 204 0.0454767183672824 354 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2337 9009472 200 µM 1.68912110826279 0.0417832085132289 no 205 0.0455981117465783 379 5742383
SGTC_1366 1683-0113 21.9 µM 1.6842195979133 0.0422225085359803 no 206 0.0460696185563524 303 708623
SGTC_861 0443-0273 110 µM 1.67371364559072 0.043176700885165 no 207 0.0470934453421689 305 6149169
SGTC_2345 9052315 157.45 µM 1.67147277309569 0.04338246274366 no 208 0.0473141661073485 341 6469265
SGTC_2496 diffractaic acid 79.83 µM 1.67137671381408 0.043391300784185 no 209 0.0473236462242609 352 94870 An apoptosis inducer which activates caspases.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.66698865583263 0.0437965812389436 no 210 0.0477583303054564 284 616764
SGTC_3084 9116877 49.47 µM 1.66604602194311 0.043884040011607 no 211 0.0478521241733184 263 27241325
SGTC_2991 9074669 71.4286 µM 1.65915077063193 0.0445280821158157 no 212 0.0485427073926503 423 17333109
SGTC_775 4577-0580 57.3 µM 1.65897586157801 0.04454451777209 no 213 0.0485603282287748 327 2006902
SGTC_2341 7987486 176.74 µM 1.65447604155065 0.0449690344921964 no 214 0.0490154136683213 379 1258686
SGTC_1255 0566-0045 221 µM 1.65253499464233 0.0451531569925484 no 215 0.0492127686885136 366 2788469
SGTC_157 1348-1695 65.819 µM 1.64747040974953 0.0456364271940569 no 216 0.0497306967247429 444 5380510
SGTC_1610 st001799 48.1 µM 1.64730705442333 0.0456520837565486 no 217 0.0497474743202391 277 621897
SGTC_2980 9014342 25.29 µM 1.64725215961508 0.0456573460418062 no 218 0.0497531133678724 346 2996599
SGTC_2717 st081029 62.2815 µM 1.63971513098532 0.0463844972452569 no 219 0.0505322056874854 301 5292846
SGTC_1689 st020265 53.493 µM 1.63896778237643 0.0464571031378825 no 220 0.0506099848106281 326 5758320 YPR016C TIF6
SGTC_2881 9058953 51.95 µM 1.63807762492305 0.0465437021049484 no 221 0.0507027509372418 390 17122249
SGTC_511 blebbistatin 171 µM 1.63665017902361 0.0466828415795529 no 222 0.0508517922266622 336 3476986 A myosin inhibitor.
SGTC_2651 TUB2.036 5 µM 1.63350827727865 0.0469902724022783 no 223 0.0511810706488037 575 15992207 YFL037W TUB2
SGTC_1678 st019265 80.2 µM 1.63247296053727 0.04709193163726 no 224 0.0512899450624631 395 5367020
SGTC_2201 6605497 169.863 µM 1.63018075853754 0.0473176336068135 no 225 0.0515316496760552 307 670741
SGTC_1617 st002906 78 µM 1.62010434187839 0.0483201097722962 no 226 0.0526049324497687 380 5150859
SGTC_3114 9122766 49.47 µM 1.61523290008398 0.0488108118487026 no 227 0.053130134166147 350 17176985
SGTC_3041 9091929 49.47 µM 1.61047593563343 0.0492938177863927 no 228 0.0536469974061031 378 25236887
SGTC_1998 st075797 76.8 µM 1.60880622426024 0.0494642566705947 no 229 0.0538293597317886 404 24208315
SGTC_3225 9130819 49.47 µM 1.60211326687657 0.0501521795134886 no 230 0.0545652823902762 374 4547121
SGTC_723 4182-0001 115 µM 1.60202963328226 0.0501608236357338 no 231 0.0545745283834469 351 744821 YLR208W SEC13
SGTC_165 k038-0023 64.381 µM 1.59922410744779 0.050451483339676 no 232 0.0548854077828356 454 46368543
SGTC_2845 9003024 42.97 µM 1.59744279398903 0.0506367274500021 no 233 0.0550835198827853 405 2990173
SGTC_1996 st072960 66.8 µM 1.59689400665239 0.050693906517457 no 234 0.0551446679979354 369 1719405
SGTC_1413 3910-0535 34.4 µM 1.59687811096066 0.0506955634820435 no 235 0.0551464399592794 361 2876951
SGTC_1527 coumarin 137 µM 1.5962560093343 0.0507604451477617 no 236 0.0552158236453479 358 323 A hepatotoxic, DNA x-linker.
SGTC_580 1123-0028 41 µM 1.59453468096457 0.0509403145602953 no 237 0.0554081646925151 435 1677248 YPR107C YTH1
SGTC_1611 st001856 99.4 µM 1.59224407135892 0.0511804571552086 no 238 0.0556649371249332 363 647478
SGTC_1978 st071761 42 µM 1.58886773871854 0.0515360660702412 no 239 0.0560451280388918 343 5147680
SGTC_3050 9093513 49.47 µM 1.5877142898039 0.0516580012203272 no 240 0.0561754801280543 347 25236664
SGTC_2432 5630864 12.22 µM 1.58517684394699 0.0519270508124948 no 241 0.056463080060609 372 5714970
SGTC_1952 st077036 64.1 µM 1.58365504396331 0.0520889431792216 no 242 0.0566361202340266 403 2937007
SGTC_503 tyrphostin 8 294 µM 1.57759251658003 0.0527378716785732 no 243 0.0573296263412667 391 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2858 9025781 8.96 µM 1.57577799803759 0.0529333386799783 no 244 0.0575384873322944 514 4894980 YPL153C RAD53
SGTC_2643 anethole 100 µM 1.56686232321717 0.0539021312733847 no 245 0.0585734379902639 403 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_192 3455-0609 60.9 µM 1.56205226845842 0.0544306001743516 no 246 0.0591378380322601 373 3769639
SGTC_3103 9120822 49.47 µM 1.56183437256551 0.0544546365494559 no 247 0.0591635060403403 401 17141819
SGTC_176 1486-1328 72.834 µM 1.5588385711164 0.0547859591501472 no 248 0.0595172962541297 442 22310231
SGTC_1967 st070177 51.4 µM 1.55826351929834 0.0548497393013229 no 249 0.0595853965093809 345 5729214
SGTC_2926 9010726 65.15 µM 1.55264717266083 0.0554757494927941 no 250 0.0602537246842935 411 2994293
SGTC_1766 st045414 44.774 µM 1.5509205600434 0.0556693309720185 no 251 0.0604603613062574 430 253960
SGTC_1940 st075990 51.1 µM 1.54350145542368 0.0565072073903881 no 252 0.0613545773181329 444 1084979
SGTC_2387 9077560 195.08 µM 1.54307370912717 0.0565558162703092 no 253 0.0614064464292356 394 5303272
SGTC_1168 k815-0004 80.5 µM 1.5408436507787 0.0568097728827945 no 254 0.0616774214104198 389 642433
SGTC_625 k213-0058 121 µM 1.53866467690353 0.0570587787322871 no 255 0.0619430900034007 585 3655420
SGTC_3167 9103034 49.47 µM 1.53619497700661 0.0573420457415651 no 256 0.0622452837932966 298 5127859
SGTC_1482 3346-2049 8.48 µM 1.53343173912124 0.0576602910039683 no 257 0.0625847567521904 388 3826804
SGTC_2374 9071832 200 µM 1.5260152281137 0.0585213278290916 no 258 0.063503036041243 369 17381698
SGTC_2874 9043904 71.43 µM 1.52352167829617 0.05881307930763 no 259 0.0638141206707759 319 4463428
SGTC_2531 methyl deoxycholate 70.07 µM 1.52247919645504 0.0589353900969602 no 260 0.0639445270925963 393 16667744 Haematoxylin.
SGTC_1150 3909-7983 10.9 µM 1.51482111352899 0.0598400141302312 no 261 0.0649088560445553 447 23965914
SGTC_2295 7971645 200 µM 1.51448756107499 0.0598796614054195 no 262 0.0649511131589797 424 2978226 YKL099C UTP11
SGTC_1296 1068-0102 11.9 µM 1.51188455747539 0.0601897712176261 no 263 0.0652816166075949 406 767053
SGTC_2030 5175110 200 µM 1.50959884670515 0.0604631156917281 no 264 0.0655729079126839 395 2831986
SGTC_33 0986-0033 35.816 µM 1.50498136104799 0.0610182756263889 no 265 0.0661644344069077 369 2848082
SGTC_1628 st004252 77.7 µM 1.49332538358897 0.0624373989486167 no 266 0.067676017105473 448 692968
SGTC_897 1000-0139 31.4 µM 1.48690131923759 0.0632304606853118 no 267 0.0685204378967761 413 6151020
SGTC_252 miconazole 1.30953 nM 1.4861318740682 0.0633259736483954 no 268 0.0686221214322076 408 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1717 st033143 58.0435 µM 1.48528234313115 0.0634315582608328 no 269 0.0687345235810656 475 674616
SGTC_1995 st072814 61.1 µM 1.48448486769058 0.0635307977534625 no 270 0.0688401673618996 399 5769371
SGTC_1780 st038448 24.544 µM 1.48286566284754 0.0637326666329768 no 271 0.0690550529894578 416 728868 YDL195W SEC31
SGTC_2723 salbutamol 83.58 µM 1.4821863409298 0.0638175072366956 no 272 0.0691453599859132 318 9884233 β2-adrenoceptor agonist
SGTC_3297 9117502 71.43 µM 1.48193928721296 0.0638483835818587 no 273 0.0691782251142764 375 7453720
SGTC_3250 9135583 49.47 µM 1.47950193482214 0.0641536227420897 no 274 0.0695031073098495 385 7699353
SGTC_171 k064-0041 9.68 µM 1.47796355041104 0.0643468637956664 no 275 0.0697087673228066 347 53325
SGTC_1758 st042942 75.2445 µM 1.47623374711535 0.0645646894601619 no 276 0.0699405764682525 418 669317
SGTC_972 1319-0219 195 µM 1.47454285168983 0.0647781688307659 no 277 0.070167744459917 445 23903702
SGTC_1864 st057645 30.4 µM 1.47238191045402 0.0650517898832685 no 278 0.0704588876369651 382 688666
SGTC_271 rotenone 740 µM 1.47216119789276 0.0650797871935081 no 279 0.0704886763907272 477 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3016 9080866 49.47 µM 1.47110119461321 0.0652143785565995 no 280 0.0706318760125324 455 17066299
SGTC_9 0092-0002 10.449 µM 1.46619565746245 0.0658400615333677 no 281 0.0712974956576893 448 759368
SGTC_2055 5235184 200 µM 1.46240113964108 0.0663272215670757 no 282 0.0718156586649989 453 2836034
SGTC_1364 1653-0028 37.6 µM 1.46115050602688 0.0664883945949815 no 283 0.0719870711519161 455 5718652
SGTC_51 1013-0126 23.419 µM 1.45684939499362 0.0670450072152895 no 284 0.072578978761101 422 1627850
SGTC_3157 9099274 49.47 µM 1.45219959782998 0.0676507904115396 no 285 0.0732230572484255 409 17217662
SGTC_2115 tiliquinol 12.7705 µM 1.44999570305035 0.0679393905772135 no 286 0.0735298587376387 409 71208 A bioactive hydroxyquinoline.
SGTC_3329 9141233 27.5565 µM 1.4492631381625 0.0680355302313687 no 287 0.0736320555701188 416 4909101 YNL103W MET4
SGTC_944 3370-0224 231 µM 1.44679795896718 0.0683598246285883 no 288 0.0739767592983835 456 4580514
SGTC_2199 6590217 200 µM 1.44563839690854 0.0685127769229226 no 289 0.0741393255622038 378 703109
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.4439460911201 0.0687364745140232 no 290 0.0743770700537936 441 140250 A respiratory chain inhibitor.
SGTC_1047 2043-3044 82 µM 1.44319219097204 0.0688363100264132 no 291 0.0744831693582011 473 669592
SGTC_966 1300-0360 30.2 µM 1.44195465397073 0.0690004336576679 no 292 0.0746575832024024 452 70588
SGTC_1298 1079-1278 263 µM 1.44155970044384 0.0690528763030697 no 293 0.0747133120375318 470 2840950
SGTC_2921 7974240 10.71 µM 1.43744896282215 0.0696005326826254 no 294 0.0752952324108055 457 2979074 YDR527W RBA50
SGTC_412 gemfibrozil 100 µM 1.43705375640478 0.0696533600947629 no 295 0.0753513598015755 381 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2691 st077356 60.2 µM 1.43170329799597 0.0703715995655166 no 296 0.0761143760821057 469 2839272
SGTC_1295 1013-0063 9.78 µM 1.43050793515991 0.0705328392605967 no 297 0.0762856449987296 478 6826038
SGTC_356 1634-0012 32.5 µM 1.42968266903541 0.0706443230803444 no 298 0.0764040583072747 498 735457
SGTC_1124 fisetin 1.16336 µM 1.42919781856103 0.0707098838436092 no 299 0.0764736922627836 427 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_632 0781-2353 4.65 µM 1.42555417828501 0.0712040683086805 no 300 0.0769985354132493 504 6811515 YHR007C ERG11
SGTC_1322 1348-1070 12 µM 1.42554853961796 0.0712048351270136 no 301 0.0769993497435879 405 6758089
SGTC_2061 5245884 80.95 µM 1.42478884042327 0.0713082067608109 no 302 0.0771091245609342 482 573863
SGTC_3002 9075603 71.4286 µM 1.42472815178643 0.0713164695791916 no 303 0.0771178990589319 476 20105405
SGTC_337 1315-0038 354 µM 1.42437064044116 0.0713651600233378 no 304 0.0771696042445174 454 1626437
SGTC_1833 st055984 71 µM 1.42332226069701 0.0715080888398854 no 305 0.0773213783560239 437 676288
SGTC_2444 5485484 36.41 µM 1.41657248698062 0.0724335713009058 no 306 0.0783039786152175 492 6790631
SGTC_324 1315-0088 19.6 µM 1.41612266985913 0.0724955717655312 no 307 0.0783697958905754 403 6787421
SGTC_1084 voriconazole 435 nM 1.41147723088258 0.0731382550303784 no 308 0.0790519723530709 463 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_656 4090-1979 187 µM 1.41076905011522 0.0732366116099395 no 309 0.0791563615936895 519 22330961
SGTC_1445 4239-0156 97.7 µM 1.41034760007027 0.0732951932432865 no 310 0.0792185348741568 537 4008346
SGTC_2832 7992762 51.95 µM 1.4065734934591 0.0738213936178297 no 311 0.0797769487883675 418 2985177
SGTC_1975 st070967 30.8 µM 1.40303063759685 0.0743179747912884 no 312 0.0803038515275583 517 261391
SGTC_306 1672-3436 11.6 µM 1.40186722932998 0.0744815979828414 no 313 0.0804774489844829 488 6797378
SGTC_2118 5526350 200 µM 1.40157516656115 0.0745227172082003 no 314 0.0805210734903121 492 743594
SGTC_2226 7298446 200 µM 1.39883043042784 0.0749099929009935 no 315 0.0809319193278095 406 3283010
SGTC_1392 3455-1037 33.9 µM 1.39823437283998 0.0749942977410518 no 316 0.0810213489818681 477 981132
SGTC_2066 5222451 176 µM 1.39743971338654 0.0751068048379274 no 317 0.0811406918929259 553 2281147
SGTC_1982 st072467 71.9 µM 1.39741862311947 0.0751097925293408 no 318 0.0811438610605829 539 3163533
SGTC_2139 5578692 56.4705 µM 1.39565313966246 0.0753602160830418 no 319 0.0814094859707246 410 650991 YMR113W FOL3
SGTC_69 0096-0274 206.684 µM 1.39009436637692 0.0761528527617679 no 320 0.0822501118947854 555 6741392
SGTC_1318 1280-3875 124 µM 1.38807145877848 0.0764428727975926 no 321 0.0825576432705031 521 373245
SGTC_1752 st044819 83.042 µM 1.38651753353392 0.0766662258930365 no 322 0.0827944650741273 486 441209 YML126C ERG13
SGTC_1480 1070-0044 41.2 µM 1.38604603733505 0.076734094338616 no 323 0.0828664231680904 490 3124987
SGTC_2058 5236698 133 µM 1.38522006327589 0.0768530973944936 no 324 0.0829925938218558 497 766665
SGTC_1005 4092-0690 4.4 µM 1.38457657563308 0.0769459057270017 no 325 0.0830909890815226 477 1529343
SGTC_2459 5811157 9.22 µM 1.38115813512181 0.0774403662898096 no 326 0.0836151719373388 473 2870684 YBR192W RIM2
SGTC_302 1094-0063 18.9 µM 1.38108513214819 0.07745095206593 no 327 0.0836263932306115 426 5440289
SGTC_343 4130-2827 29.8 µM 1.37889565797393 0.0777689471403232 no 328 0.0839634635572966 522 1118244
SGTC_310 1273-0058 1.06 µM 1.3755843166795 0.0782517614771504 no 329 0.0844751824805951 732 2734232
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.37295940922649 0.0786361020198178 no 330 0.0848824829078566 535 442882
SGTC_3122 9126309 49.47 µM 1.37291685950271 0.0786423439387237 no 331 0.0848890973487301 459 17591206
SGTC_833 3852-0053 558 µM 1.37127099078951 0.078884076307333 no 332 0.0851452476313301 556 3123681
SGTC_1210 3013-0140 750 nM 1.36924489334981 0.0791824261854584 no 333 0.085461368609071 514 905973
SGTC_363 0455-0021 3.06 µM 1.36851815186493 0.0792896493295385 no 334 0.0855749720728933 528 4597466
SGTC_2311 7694451 200 µM 1.36286190470618 0.0801279296654053 no 335 0.0864630183881668 500 2163142
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.36014141650936 0.0805334960921012 no 336 0.0868925885011833 488 4330530
SGTC_2753 fluvastatin 17.09 µM 1.35622541056257 0.0811200084713271 no 337 0.0875137297043181 533 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_930 2810-3379 265 µM 1.35528271680456 0.0812616788359546 no 338 0.0876637496766658 576 1015764
SGTC_458 nppb 133 µM 1.35311992296625 0.0815874141574788 no 339 0.0880086609242264 473 4549 A chloride channel blocker.
SGTC_2148 5546263 113.568 µM 1.34654060337579 0.0825843690667053 no 340 0.089064117465704 485 792097
SGTC_1897 st060201 15 µM 1.33777895774244 0.0839262091449971 no 341 0.0904842516126525 486 611878
SGTC_1233 0325-0408 14.2 µM 1.33483203582872 0.0843811882848514 no 342 0.0909656629357457 515 12874
SGTC_2751 anetholtrithion 17.25 µM 1.3336784238151 0.0845597991479505 no 343 0.0911546344303361 522 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.33317476839404 0.084637867734703 no 344 0.0912372287226069 594 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1239 0337-0584 35.4 µM 1.33076422497335 0.0850122601731848 no 345 0.0916333014189399 588 914301 YML130C ERO1
SGTC_2601 securinine 100 µM 1.32916258974241 0.0852617029161996 no 346 0.0918971672140874 519 442872 A GABA receptor antagonist.
SGTC_2430 5571206 200 µM 1.32731982175978 0.0855493782353808 no 347 0.0922014548069024 590 1731771
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.3270723352284 0.0855880687638856 no 348 0.0922423778340359 510 688662
SGTC_906 1165-0455 526 µM 1.32444191609693 0.0860001023910807 no 349 0.0926781607347295 512 3252859
SGTC_1624 st003710 6.25 µM 1.31974069000609 0.0867402049841356 no 350 0.0934608048456924 592 24207033
SGTC_321 4534-3890 65.3 µM 1.31818952447884 0.0869854425584974 no 351 0.0937201056888714 530 699746
SGTC_3165 9101544 49.47 µM 1.31723024829683 0.0871373620404549 no 352 0.0938807288240341 549 5002184
SGTC_2273 7815444 169.05 µM 1.31347847614793 0.0877334290692824 no 353 0.0945108845206216 499 2824616
SGTC_1383 3049-0032 20.7 µM 1.30867399150299 0.088501181999464 no 354 0.0953224026883469 553 712864
SGTC_2959 9079155 11 µM 1.30042659467185 0.0898307627355887 no 355 0.0967273999268017 472 16189457
SGTC_3085 9117376 49.47 µM 1.29739914069419 0.0903225323448827 no 356 0.0972469440205335 548 16480349
SGTC_900 1112-0045 141 µM 1.29738753997931 0.090324420564186 no 357 0.0972489387600037 424 56211 YIL048W NEO1
SGTC_3118 9124250 49.47 µM 1.29705881258784 0.0903779388841082 no 358 0.0973054758167778 496 1504786
SGTC_2802 7925815 54.55 µM 1.29651363385064 0.0904667483750376 no 359 0.0973992929897448 570 1262923
SGTC_2697 mebhydrolin 72.4 µM 1.29500019502721 0.0907136267900852 no 360 0.097660081102214 612 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_247 mechlorethamine 29.705 µM 1.28822009477212 0.0918257642632739 no 361 0.0988346794439059 491 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_137 0438-0332 85.389 µM 1.28666243729536 0.0920826869756521 no 362 0.099105985456273 690 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1424 4048-1941 275 µM 1.28424064997875 0.0924831971828156 no 363 0.0995288829837359 608 X1424
SGTC_1636 st007707 68.9 µM 1.2820605897468 0.0928448320753682 no 364 0.0999106962368675 620 403051
SGTC_2570 licareol 100 µM 1.28156970160394 0.0929264060968397 no 365 0.0999968171888258 561 443158
SGTC_2283 7944793 200 µM 1.28094375614279 0.0930305003001508 no 366 0.100106711084904 560 2970533
SGTC_1385 3091-4834 14.1 µM 1.278642528198 0.0934139334902637 no 367 0.100511483314424 517 4072814
SGTC_3031 9088762 49.47 µM 1.27485143073364 0.0940481540743462 no 368 0.101180916420519 564 205253
SGTC_537 1334-0398 209 µM 1.27460634695662 0.0940892637205168 no 369 0.101224304932166 590 5846986
SGTC_2205 7238770 200 µM 1.27446750394506 0.0941125587291039 no 370 0.10124889107935 519 279867
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.27401956328784 0.0941877429892316 no 371 0.10132824151543 573 688669
SGTC_2885 9057732 51.95 µM 1.27355714113201 0.0942654043547776 no 372 0.101410204793643 553 6471414
SGTC_1334 1486-0610 236 µM 1.26853691493459 0.0951115664959859 no 373 0.102303138293969 578 3742339
SGTC_107 0358-0022 2.6945 µM 1.268098323426 0.095185756219115 no 374 0.102381420095456 410 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1056 3448-1962 115 µM 1.2606606189801 0.0964503731987294 no 375 0.103715574094101 551 715507
SGTC_1017 4239-0030 168 µM 1.25977277958807 0.0966021515657415 no 376 0.103875670998331 606 1149593
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.25782151729474 0.0969363411280978 no 377 0.104228156045196 659 688664
SGTC_2196 6573537 42.6665 µM 1.25578852528046 0.0972854304247375 no 378 0.104596326499294 546 2903087
SGTC_1990 st072050 59.8 µM 1.2555784145947 0.0973215614915927 no 379 0.104634430734887 587 17233948
SGTC_695 3505-6186 243 µM 1.25354790140494 0.097671240129855 no 380 0.105003188899824 591 1819379
SGTC_206 4546-0025 72.014 µM 1.24449476111887 0.0992415118141722 no 381 0.106658763148729 665 6620745 YIL048W NEO1
SGTC_797 k781-0471 270 µM 1.24322582568253 0.0994630760521588 no 382 0.106892314244231 604 23738129
SGTC_1088 bifonazole 369 nM 1.24293440674242 0.0995140106742628 no 383 0.106946002768056 578 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_23 0213-0011 39.996 µM 1.2401758707935 0.0999970961069555 no 384 0.107455175554676 582 627608
SGTC_1659 st012954 42.1 µM 1.23207481496496 0.101425679141845 no 385 0.108960569138242 574 24207262
SGTC_1469 k284-2957 126 µM 1.22992371965552 0.101807500462606 no 386 0.109362835477918 574 23884841
SGTC_2884 9058502 51.95 µM 1.22919924425882 0.101936330729025 no 387 0.10949855610512 606 6471554
SGTC_200 k038-0079 37.545 µM 1.22736053080895 0.102263833627143 no 388 0.10984355706228 569 3436683
SGTC_2856 9022925 19.48 µM 1.22596391343526 0.102513103414868 no 389 0.110106127619297 618 4944862
SGTC_2955 9076254 12.21 µM 1.22318308971146 0.103010742704956 no 390 0.110630275554573 556 16459619
SGTC_1707 st032323 6.317 µM 1.21951856630623 0.103669200181234 no 391 0.11132371671081 628 3132057 YMR211W DML1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.21737000501996 0.10405668033242 no 392 0.111731735020189 572 6708514
SGTC_3279 9140807 49.47 µM 1.21298049726716 0.104851563642187 no 393 0.112568638523048 600 45595718
SGTC_1668 st014914 51.6 µM 1.20888436635264 0.10559727722867 no 394 0.113353636580644 594 2839556
SGTC_1603 st002045 67.8 µM 1.20844595486089 0.105677318056374 no 395 0.11343788616902 619 5887985
SGTC_1486 3970-0793 4.53 µM 1.20568195053552 0.106182952754998 no 396 0.113970073561647 630 2844330
SGTC_749 1000-0129 128 µM 1.20464578111814 0.106372954655717 no 397 0.114170037582579 661 708470
SGTC_2625 euphol 100 µM 1.20445250909622 0.106408422006795 no 398 0.11420736360676 666 6708538 A triterpene alcohol.
SGTC_210 3551-0445 56.827 µM 1.20343060792463 0.106596093041479 no 399 0.114404864659231 632 2865180 YOR207C RET1
SGTC_2184 6075246 200 µM 1.20096746237201 0.10704942875048 no 400 0.114881911560395 622 2267320
SGTC_2596 sinensetin 100 µM 1.20020826103974 0.107189437789579 no 401 0.115029233885285 593 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1950 st077106 7.18 µM 1.19827268557849 0.10754698663091 no 402 0.11540543829406 634 13831864
SGTC_2745 rifampicin 24.3 µM 1.19502448806072 0.108148939300015 no 403 0.116038731330685 475 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2114 5491910 81.25 µM 1.19003449023709 0.109078399320143 no 404 0.117016418123607 642 2849228
SGTC_2182 6325192 200 µM 1.18871727283646 0.10932470523873 no 405 0.117275470628749 614 736248
SGTC_1855 st056195 39.6 µM 1.18806231205917 0.109447324688518 no 406 0.117404430551095 618 4028379
SGTC_1955 wogonin 32.4 µM 1.18696939044146 0.109652157503647 no 407 0.117619847255286 602 5281703 A flavanone.
SGTC_1804 st050076 49.1 µM 1.18611195231142 0.109813049110041 no 408 0.117789045508235 642 3895976
SGTC_1868 st057644 42.7 µM 1.18600012875802 0.109834044414974 no 409 0.11781112433787 667 688665
SGTC_787 4152-0075 138 µM 1.1826485575625 0.110464652616994 no 410 0.118474229841899 620 9566539
SGTC_2603 homopterocarpin 100 µM 1.18227639836638 0.110534835281307 no 411 0.118548023620149 647 101795 A weak amylase inhibitor.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.17983718740103 0.110995618841897 no 412 0.11903248798672 615 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1915 st067105 30.6 µM 1.1796917366251 0.111023138885341 no 413 0.119061420821272 648 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_505 gw-5074 63.9 µM 1.17963953879334 0.111033016178118 no 414 0.119071805140639 646 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1039 k821-0043 94 µM 1.17482445539437 0.111946873353932 no 415 0.120032477003495 649 15992768
SGTC_3260 9137109 49.47 µM 1.17332651668028 0.112232261690101 no 416 0.12033244630171 524 17478346
SGTC_1178 0988-0033 191 µM 1.17328637403012 0.112239916843329 no 417 0.120340492315791 663 5392207
SGTC_1667 st014849 34.6 µM 1.1723908699349 0.112410785378526 no 418 0.120520081702009 673 5348460
SGTC_3189 9110682 49.47 µM 1.17025878994353 0.11281834913941 no 419 0.120948420262739 628 17122418
SGTC_646 4092-0839 27.3 µM 1.16492235814922 0.113843071712274 no 420 0.122025211185284 660 877796
SGTC_2171 5739187 198.077 µM 1.16365520783067 0.114087366354206 no 421 0.122281884241467 571 2262761
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.16316141839952 0.114182665344171 no 422 0.12238200841915 642 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3101 9120531 49.47 µM 1.16096167984568 0.114607893161411 no 423 0.122828741735381 664 24824904
SGTC_3125 9127534 49.47 µM 1.15914145730854 0.114960608527868 no 424 0.123199264816271 553 1639235
SGTC_95 0471-0001 561.058 µM 1.15894413442315 0.114998891292295 no 425 0.12323947871861 639 4015405
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.15847245064181 0.115090439761864 no 426 0.123335643945228 545 1241132 A phosphatase inhibitor.
SGTC_745 0469-0705 296 µM 1.15688164252354 0.115399579645869 no 427 0.123660359910487 746 3486736
SGTC_2996 9066192 71.4286 µM 1.15178588733261 0.116393803093629 no 428 0.124704534267094 635 6472854
SGTC_2638 epoxomicin 18 µM 1.15129852378563 0.116489209113649 no 429 0.124804722133949 698 9915668 A protesome inhibitor.
SGTC_57 miconazole 162.5 nM 1.14999359126787 0.116744935038892 no 430 0.125073255432396 632 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1556 plumbagin 1.48 µM 1.14973702727601 0.116795260333355 no 431 0.125126099447739 586 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_701 4424-0219 185 µM 1.14835294906668 0.117067013980994 no 432 0.125411444439084 733 2911779
SGTC_1217 1183-1422 255 µM 1.14792743534191 0.117150650464124 no 433 0.125499260615196 716 2849664
SGTC_2413 inermin 26.06 µM 1.14789659675645 0.117156713560424 no 434 0.125505626652247 687 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1796 st049173 110.4 µM 1.14622859882958 0.117484985664593 no 435 0.125850288760867 611 94134
SGTC_2939 9044578 71.43 µM 1.14603383049556 0.11752335967446 no 436 0.125890577173839 644 2653634
SGTC_1121 fusaric acid 630.51 nM 1.14486495868298 0.117753841748874 no 437 0.12613255077319 667 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1574 spiramycin 23.7 µM 1.14407661579339 0.117909470366906 no 438 0.12629593226678 665 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1737 st035557 69.7 µM 1.14327109874165 0.118068639630026 no 439 0.126463025326451 557 5716916
SGTC_1134 3477-0009 42.5 µM 1.1409876418127 0.118520673993707 no 440 0.126937532888264 716 3973534
SGTC_830 4076-0286 57.8 µM 1.13928626744359 0.11885827318984 no 441 0.127291887103602 813 6866659
SGTC_977 1348-1378 135 µM 1.13769643715503 0.119174352330848 no 442 0.12762363083289 685 X977
SGTC_462 ag-879 158 µM 1.13680179278069 0.119352480046935 no 443 0.127810576868211 705 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_37 0566-0070 1.56 µM 1.13529768399806 0.119652378170654 no 444 0.128125306141973 718 1626686
SGTC_741 4582-0002 126 µM 1.13212361720127 0.120286985610557 no 445 0.128791233513459 669 2912688
SGTC_2186 6124449 200 µM 1.13145956596294 0.120420052157578 no 446 0.128930856338653 671 3834182 YLR033W RSC58
SGTC_881 0833-0569 170 µM 1.13057422901033 0.120597622465534 no 447 0.129117169733558 682 5418700
SGTC_2218 6965428 192.983 µM 1.12940492440469 0.120832430043462 no 448 0.129363528225088 687 675684
SGTC_1115 galangin 695.678 nM 1.12709128126052 0.121297979520617 no 449 0.12985194462316 733 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_413 propylparaben 100 µM 1.12701273763913 0.121313806113508 no 450 0.129868547774347 655 7175 A pharmaceutical preservative.
SGTC_443 clozapine 122 µM 1.12463118228949 0.121794380798071 no 451 0.130372677208408 589 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_593 1203-0218 61.7 µM 1.12355627219184 0.122011724703838 no 452 0.130600657784475 721 3666956
SGTC_722 3534-0461 190 µM 1.12291051275785 0.122142426408925 no 453 0.130737751107733 679 658262
SGTC_1922 5578187 25 µM 1.12164414770092 0.12239902403702 no 454 0.131006886399599 652 1350412
SGTC_894 0960-0238 55.9 µM 1.12017114628467 0.122697967091785 no 455 0.131320418544807 693 6741907 YDL195W SEC31
SGTC_912 3474-0017 2.18 µM 1.11914375182833 0.122906777938427 no 456 0.131539408595584 695 3360550
SGTC_1925 st057770 10.1 µM 1.11724823965232 0.12329268138499 no 457 0.131944099962828 622 5989122
SGTC_884 0851-0618 334 µM 1.1156885454124 0.12361085242504 no 458 0.132277737683952 717 9642473
SGTC_35 0133-0054 64.071 µM 1.11335521527312 0.12408791469587 no 459 0.132777950570716 644 99677
SGTC_867 0518-0118 155 µM 1.11237943651843 0.124287799582492 no 460 0.13298752113577 708 6848158
SGTC_396 dithiazanine 1.25 µM 1.10857155259159 0.125069985094807 no 461 0.133807527916744 652 10578 An antihelmenthic.
SGTC_799 1310-0557 151 µM 1.10654337937683 0.125487996847962 no 462 0.134245699470136 694 5354492
SGTC_620 0109-0052 432 µM 1.10575869554694 0.125649983515656 no 463 0.134415488605319 725 493037
SGTC_2634 4'-methoxyflavone 100 µM 1.10167257334085 0.126495862211106 no 464 0.13530202236001 647 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1516 st013856 110 µM 1.09933151165897 0.126982274975477 no 465 0.135811746133252 678 5281404 A mutagen and neurotoxin.
SGTC_958 1222-0007 33 µM 1.09547173008738 0.127787078531149 no 466 0.136655012015258 756 7312461
SGTC_2553 4-methylesculetin 85.09 µM 1.09376530907061 0.128144012293576 no 467 0.137028961276342 704 5319502
SGTC_1877 wortmannin 25 µM 1.09363145946158 0.128172039006822 no 468 0.137058322950917 765 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2954 9074818 52.69 µM 1.09289939285641 0.128325401439633 no 469 0.137218987448639 691 16648742
SGTC_1024 4507-0395 26 µM 1.0911534264357 0.128691682390073 no 470 0.137602688660521 682 4201836
SGTC_88 0180-0332 8.668 µM 1.09114460710945 0.128693534409025 no 471 0.137604628691335 719 3101745
SGTC_391 gliotoxin 8.33 µM 1.09104376982137 0.128714711101715 no 472 0.137626811695366 755 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1132 3456-3614 2.5 µM 1.08924310238036 0.129093273765824 no 473 0.138023348084337 818 3125502
SGTC_1404 3909-7820 48.3 µM 1.08842902022789 0.129264675177014 no 474 0.138202877805735 697 23741373
SGTC_1373 2887-0003 58.5 µM 1.08811389745412 0.129331065217137 no 475 0.138272414626287 693 776948
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.08707562710574 0.12954997511054 no 476 0.138501694123821 717 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2210 7115885 190.385 µM 1.0854786132234 0.129887191848405 no 477 0.138854865468891 742 2927039
SGTC_1432 4049-0298 68.4 µM 1.08461992904965 0.130068757921696 no 478 0.139045012324693 700 741646
SGTC_353 1988-1175 58.3 µM 1.08340954782912 0.130324987428265 no 479 0.139313339797534 666 2788357
SGTC_1490 4089-0339 670 nM 1.08275585667222 0.130463514541411 no 480 0.139458401966595 694 742542
SGTC_294 k038-0071 157 µM 1.081845954022 0.130656506250517 no 481 0.139660491627313 731 24152826
SGTC_325 2810-4341 181 µM 1.0818001812731 0.130666219930364 no 482 0.139670663026737 728 774970
SGTC_2403 6032726 181.2 µM 1.08178251573293 0.130669968962647 no 483 0.139674588712548 695 2881040
SGTC_919 tnp00227 403.569 nM 1.07824784442962 0.131421603641538 no 484 0.140461582810793 763 1269246 A methoxyflavone. YNL221C POP1
SGTC_1769 st044406 64.4 µM 1.07804749132636 0.131464297192819 no 485 0.14050628138465 737 670903
SGTC_1045 1348-1485 165 µM 1.07763513839829 0.131552196242218 no 486 0.140598307290443 794 6810614
SGTC_1148 3909-7663 27.7 µM 1.0776040317708 0.131558828719306 no 487 0.140605251098816 749 4084526
SGTC_857 0438-0306 1.35 µM 1.07757532282799 0.13156495017288 no 488 0.140611659888144 722 4686136
SGTC_576 1073-0113 22.7 µM 1.07756620532689 0.131566894289767 no 489 0.140613695258623 908 5439563
SGTC_2808 7946468 45.46 µM 1.07667751562983 0.131756483989048 no 490 0.1408121803217 760 2970879
SGTC_1698 5-fluorocytosine 1.055 µM 1.07423996833308 0.132277468378999 no 491 0.141357571534713 734 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1054 3429-0080 167 µM 1.07270919293202 0.132605370617111 no 492 0.141700807215814 744 1162877
SGTC_1116 jasmonic acid 1.58368 µM 1.07150994286931 0.132862648803258 no 493 0.141970101212057 752 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_293 4049-0273 38.5 µM 1.06995108635595 0.133197587746263 no 494 0.142320663145584 688 1380311
SGTC_31 0508-1974 57.237 µM 1.0689294230656 0.133417419246066 no 495 0.142550736340906 711 6810525
SGTC_2343 7990716 14.84 µM 1.06614465890914 0.134017884235827 no 496 0.143179127168765 755 6456862
SGTC_1953 st076800 12.1 µM 1.06598704728708 0.134051924688478 no 497 0.143214748590255 736 297591
SGTC_1770 st043884 66.3 µM 1.06524980607117 0.134211230561092 no 498 0.143381450173482 737 670149
SGTC_1059 3448-6867 171 µM 1.06463749013537 0.134343640918986 no 499 0.143520003788999 760 3934407
SGTC_1382 3002-2117 298 µM 1.06275408178003 0.134751481049192 no 500 0.14394674402993 783 1497314
SGTC_177 1327-0068 8.361 µM 1.06212260669326 0.134888412951669 no 501 0.144090014227573 744 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_440 fluspirilene 35.1 µM 1.05870222999304 0.135631761391179 no 502 0.144867705986746 743 3396 An atypical antipsychotic.
SGTC_2749 bexarotene 57.39 µM 1.05836479861967 0.135705246941726 no 503 0.144944580701715 710 82146 An retinoic acid receptor inhibitor.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.05260259123839 0.136964346094018 no 504 0.146261584539317 689 521171
SGTC_1735 st034310 56.75 µM 1.05147010326651 0.137212741567856 no 505 0.146521366709007 743 871153
SGTC_159 3970-0959 50 µM 1.05071553617959 0.137378416067022 no 506 0.146694629177107 947 6615653
SGTC_1347 1493-0251 600 nM 1.05003431750873 0.137528103297336 no 507 0.14685116753566 814 3986378
SGTC_1204 4049-0315 18.3 µM 1.04997493318194 0.137541157355508 no 508 0.146864818865527 733 588402
SGTC_784 4579-0127 173 µM 1.04911961059144 0.137729271011356 no 509 0.147061535724055 803 1948547
SGTC_1135 dihydrocapsaicin 536.708 nM 1.04901349716677 0.137752621090299 no 510 0.147085953214958 722 107982 A Capsaicinoid.
SGTC_2137 5261020 140 µM 1.04887212568472 0.137783733841417 no 511 0.147118488070938 751 763655
SGTC_1389 3405-0187 19 µM 1.0463552924112 0.138338436022929 no 512 0.147698512953517 684 799890
SGTC_1819 st053448 58.6 µM 1.04525730541878 0.138580905158978 no 513 0.147952032224415 756 2857616
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.03995018095039 0.139756961436277 no 514 0.149181523446789 823 1377
SGTC_663 1486-0733 13.9 µM 1.03819463119168 0.140147479544291 no 515 0.149589725828151 794 722445 YPR165W RHO1
SGTC_96 0929-0093 37.281 µM 1.03232515280427 0.141458510525784 no 516 0.150959910896305 737 6991579
SGTC_607 4491-0986 66.8 µM 1.03216170308362 0.141495137885207 no 517 0.150998186152831 800 698981 YDR232W HEM1
SGTC_3220 9131269 49.47 µM 1.02885243158763 0.14223809303029 no 518 0.151774512078605 759 17722206
SGTC_1162 k048-0130 20.1 µM 1.02803691686402 0.142421586608075 no 519 0.151966231263171 772 6797406
SGTC_322 k048-0136 19.3 µM 1.0274570601708 0.142552153691129 no 520 0.152102647465496 725 6823282
SGTC_2239 6685329 187.64 µM 1.02720589661836 0.142608733631147 no 521 0.152161761053532 768 805680
SGTC_266 formosanin C 406 nM 1.02468820274515 0.143176736827761 no 522 0.152755165640701 779 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2418 pentamidine 31.67 µM 1.02403215184713 0.143324995533256 no 523 0.152910044453105 719 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3063 1327-0034 4 µM 1.02165677210463 0.143862666501406 no 524 0.153471688722136 760 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3293 9120939 62.045 µM 1.02060291375982 0.144101644210238 no 525 0.153721304216928 767 934087
SGTC_711 k292-0785 179 µM 1.02052374134527 0.144119608510985 no 526 0.153740067738651 772 4146315
SGTC_1 0258-0098 57.368 µM 1.01929233752587 0.144399209671926 no 527 0.154032100320882 679 6790032 YDR047W HEM12
SGTC_3115 9123671 49.47 µM 1.01893259374806 0.144480961640099 no 528 0.154117484293418 824 3286988
SGTC_1444 4112-3581 28 µM 1.01893055290967 0.144481425510673 no 529 0.154117968768824 810 2877249
SGTC_2221 6807166 181.081 µM 1.01537172123904 0.145291853905519 no 530 0.154964333892529 720 674925
SGTC_832 4083-0019 164 µM 1.01337525201877 0.145747832775497 no 531 0.155440477828946 957 1990758
SGTC_732 3970-1727 52.7 µM 1.00817410936466 0.146940248647198 no 532 0.156685442442015 811 1275699
SGTC_1345 1488-0192 31.4 µM 1.00696092243084 0.147219322753163 no 533 0.156976776718376 822 658348
SGTC_2357 9067248 200 µM 0.998688631708083 0.149131696801088 no 534 0.158972774724034 755 9150235
SGTC_726 3448-4391 34.2 µM 0.997850305190701 0.149326421441323 no 535 0.159175976237604 844 1356692
SGTC_766 1391-0721 126 µM 0.997168313974199 0.149484958025634 no 536 0.159341409163997 815 1020919 YIL115C NUP159
SGTC_1530 rhein 70.4 µM 0.996990759936904 0.149526250897076 no 537 0.159384497514186 856 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1459 k035-0031 35.7 µM 0.995154394742892 0.149953771835816 no 538 0.159830589258161 714 3877128 YMR208W ERG12
SGTC_2791 5663188 71.43 µM 0.993760767907284 0.150278763137806 no 539 0.160169675131032 770 54690634
SGTC_1744 st037937 38.9 µM 0.990913921866051 0.150944100351956 no 540 0.160863806869159 796 1016152
SGTC_1259 0671-0132 43 µM 0.988575184547655 0.151492152048051 no 541 0.161435516244408 789 X1259
SGTC_1880 MG-132 525 µM 0.987649595811148 0.15170941630093 no 542 0.16166214390863 767 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2713 st079149 53.4 µM 0.987510120810195 0.151742173334287 no 543 0.161696311919753 818 3103253
SGTC_1643 st009866 20.2 µM 0.986331350424318 0.152019206511732 no 544 0.161985270201646 818 3156273 YOR207C RET1
SGTC_1352 1496-0991 99 µM 0.982264113069027 0.152977661469103 no 545 0.162984874699329 816 3000039
SGTC_2063 5246145 200 µM 0.980071678276421 0.153495972635664 no 546 0.16352536907015 840 711240
SGTC_2725 haloperidol 53.21 µM 0.980010569086202 0.153510436035432 no 547 0.16354045079042 822 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3179 9107801 49.47 µM 0.978299753720594 0.153915720306533 no 548 0.163963045845766 821 4818259
SGTC_2347 9049783 174.81 µM 0.978118077660239 0.153958800078833 no 549 0.164007963923614 866 6467988 YPL169C MEX67
SGTC_1837 st055472 66.5 µM 0.976752905285299 0.15428277056521 no 550 0.164345748172575 838 676091
SGTC_44 0929-0055 61.211 µM 0.975985799693559 0.154465010886206 no 551 0.164535750699144 755 1379590
SGTC_212 3807-4682 38.772 µM 0.969012885902338 0.15612808088776 no 552 0.166269379970747 980 3125501 YBL034C STU1
SGTC_1999 st074831 12.5 µM 0.967086774343627 0.156589538797086 no 553 0.166750328248393 835 17112523
SGTC_1876 myriocin 605 nM 0.965552026647102 0.15695787585602 no 554 0.167134195252005 859 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1789 tunicamycin 25 nM 0.965271371586781 0.157025294229838 no 555 0.167204453517818 837 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1215 3852-0577 11.2 µM 0.962332483338627 0.157732411755598 no 556 0.167941308426578 923 2884876
SGTC_3097 9117246 49.47 µM 0.962327306345645 0.157733659219789 no 557 0.16794260827341 838 16423892
SGTC_455 paf C-16 10 µM 0.960503647492767 0.158173496902673 no 558 0.1684008980653 812 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1359 1582-0056 520 nM 0.959598245250687 0.158392164342203 no 559 0.168628726272019 898 3661189
SGTC_2467 5474540 200 µM 0.957355895227769 0.158934576933985 no 560 0.16919382588115 864 5413519
SGTC_1932 st074806 40.9 µM 0.95688944451206 0.159047561652584 no 561 0.16931152975554 889 17251235
SGTC_3108 9121785 49.47 µM 0.95666810892236 0.15910119245105 no 562 0.169367399819486 842 17140271
SGTC_844 0330-0132 15.3 µM 0.953518120748969 0.159865735368313 no 563 0.170163809700193 901 2828079
SGTC_152 4469-0003 551.229 µM 0.953024787853367 0.159985690950734 no 564 0.17028875579764 853 697280
SGTC_405 ebelactone b 50 µM 0.952326947404068 0.160155473740986 no 565 0.170465597731493 851 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_422 cantharidin 155 µM 0.94952682730694 0.160837919911041 no 566 0.171176367134887 832 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3014 9081533 49.47 µM 0.947693847375914 0.161285681031342 no 567 0.1716426670239 872 21367265
SGTC_1791 st048313 56.1 µM 0.944342711340157 0.162106398081647 no 568 0.172497273249235 829 1204976
SGTC_3195 9113082 49.47 µM 0.943470005595475 0.162320575508907 no 569 0.172720275149626 841 17018038
SGTC_179 1273-0063 6.77 µM 0.941717220116829 0.162751296318177 no 570 0.173168718155674 815 3108139
SGTC_989 1501-0895 10.3 µM 0.94041680907469 0.163071332771694 no 571 0.173501901717723 889 2830112
SGTC_1029 k015-0030 64.7 µM 0.940087755108523 0.16315237909743 no 572 0.173586274600638 840 2208316
SGTC_3311 9131146 2.8755 µM 0.939563980113766 0.163281439397023 no 573 0.173720629839378 862 4900406 YPR165W RHO1
SGTC_3208 9114115 49.47 µM 0.939124684660294 0.163389734723981 no 574 0.173833365949605 757 650895
SGTC_199 4063-0024 41.6 µM 0.937930730966017 0.163684304433396 no 575 0.174140004545401 889 306215
SGTC_2505 galangin 7.89 µM 0.935517440468578 0.164280758338034 no 576 0.17476084980876 792 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1328 1441-0025 69.2 µM 0.933965530538658 0.164665062362829 no 577 0.175160836908516 822 4562601
SGTC_596 1155-0152 116 µM 0.932400902875978 0.165053104901004 no 578 0.175564689183493 899 280313
SGTC_1231 0242-0792 125 µM 0.930910533247138 0.165423280836123 no 579 0.175949922707897 873 3707635
SGTC_2365 9042475 200 µM 0.930795872844078 0.165451782260895 no 580 0.175979582501166 853 6464479
SGTC_2316 5844804 197.44 µM 0.928640323540503 0.165988183728352 no 581 0.176537758563658 1019 776813
SGTC_3281 9140613 49.47 µM 0.923228683636935 0.167339799022551 no 582 0.177944021957864 811 16013766
SGTC_2969 9091408 28.7 µM 0.916723686408758 0.16897385197486 no 583 0.17964372540206 836 4286311
SGTC_1767 st044992 70.3 µM 0.916716636445146 0.168975628464885 no 584 0.179645573017756 879 9600693
SGTC_1283 0922-0125 16.4 µM 0.914773504147512 0.169465727334957 no 585 0.180155273600646 950 3360884
SGTC_648 0375-0473 33.3 µM 0.914510863539057 0.169532040734173 no 586 0.180224236101706 911 1713139
SGTC_1369 1866-0067 208 µM 0.912589758658403 0.170017601365808 no 587 0.180729171306692 951 3531355
SGTC_3062 9077494 49.47 µM 0.909110897205454 0.170899152335171 no 588 0.181645795504715 872 16459633
SGTC_3069 9117009 49.47 µM 0.907755978287919 0.17124328162411 no 589 0.182003580663125 788 41904981
SGTC_367 0335-0881 7.1 µM 0.905903031852314 0.171714619254055 no 590 0.182493589725101 904 23828853
SGTC_2256 7954252 200 µM 0.905195862285324 0.171894721645591 no 591 0.182680816772916 778 2972920
SGTC_2815 7968870 71.43 µM 0.904295933625013 0.17212409039478 no 592 0.182919251212143 899 2977326 YHR190W ERG9
SGTC_2970 9090938 41.86 µM 0.902894113020564 0.172481767468635 no 593 0.183291047678542 959 17217104
SGTC_1365 1672-3266 55.4 µM 0.899826658016907 0.173266086337916 no 594 0.184106252689436 933 6415873
SGTC_374 0880-0231 82.3 µM 0.899598531184912 0.173324506770767 no 595 0.184166969575298 920 6833587
SGTC_545 4218-0007 221 µM 0.897127022402614 0.173958233057138 no 596 0.184825570427889 862 2840508
SGTC_3197 9113331 49.47 µM 0.896942668091895 0.174005562821293 no 597 0.184874755256653 906 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1748 st037455 53.6035 µM 0.896581462795002 0.174098319734001 no 598 0.184971146643625 881 580690
SGTC_1000 4048-0884 8.67 µM 0.895915996676489 0.174269292591734 no 599 0.185148814937745 874 13040088
SGTC_1786 berberine 21.6 µM 0.889267790126522 0.175983216372398 no 600 0.186929588890832 865 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_907 3448-6986 75.5 µM 0.887171317263915 0.176525898262138 no 601 0.187493336169013 977 590582
SGTC_1254 0550-0035 264 µM 0.886149440171065 0.176790799245507 no 602 0.18776850219491 965 15121435
SGTC_3241 9133421 49.47 µM 0.885749280512252 0.176894600981398 no 603 0.187876323141067 942 17018221
SGTC_279 1273-0055 2.93 µM 0.885247792342851 0.177024741785421 no 604 0.188011500495424 1013 2847562
SGTC_2146 5545642 200 µM 0.88478537829625 0.177144796087102 no 605 0.188136198516267 963 825326
SGTC_619 1652-1634 108 µM 0.882947385178286 0.177622493578623 no 606 0.188632349907404 871 5400454
SGTC_3240 9133527 49.47 µM 0.882817286636814 0.177656337185798 no 607 0.18866749950014 901 17617455
SGTC_1268 0828-0275 2.46 µM 0.879988937358198 0.178393104595269 no 608 0.189432651262395 976 745337
SGTC_1946 st076057 65.1 µM 0.879619292309275 0.178489536870199 no 609 0.189532792047127 823 953009
SGTC_1494 4358-1428 177 µM 0.878971042418707 0.178658730296651 no 610 0.189708488485296 975 1564571
SGTC_3238 9133470 49.47 µM 0.878749359266062 0.17871661283485 no 611 0.18976859468316 937 3534688
SGTC_2393 9031399 185.94 µM 0.878506894514051 0.178779935066186 no 612 0.189834348920869 944 1526623 YDL150W RPC53
SGTC_1087 pterostilbene 9.05 µM 0.877666094047393 0.178999628382709 no 613 0.190062474870914 960 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1169 aniline yellow 25.8 µM 0.875818675772305 0.179482937913711 no 614 0.190564307795924 909 6051 A DNA damaging agent.
SGTC_581 0958-0271 211 µM 0.875713849744404 0.179510386387081 no 615 0.190592807117769 1006 4591145
SGTC_540 1187-0821 17.3 µM 0.873816682088312 0.180007611642823 no 616 0.191109047049809 922 847520
SGTC_3010 9080089 71.4286 µM 0.873711622972718 0.180035171644731 no 617 0.191137659809659 945 17027233
SGTC_3312 9133330 71.43 µM 0.872019199894041 0.180479507526893 no 618 0.191598951686231 1003 17617324
SGTC_2678 equilin 100 µM 0.871540987164254 0.180605184055265 no 619 0.191729418236439 973 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1930 st074634 34.3 µM 0.871142988363169 0.180709821825298 no 620 0.191838042198503 969 684253 YOR116C RPO31
SGTC_1224 0823-0416 294 µM 0.870670162434997 0.180834181768229 no 621 0.191967137336606 964 3598164
SGTC_895 0964-0006 13.7 µM 0.869529369777029 0.181134447243847 no 622 0.192278825516897 948 6738897
SGTC_2700 st077718 96.8 µM 0.868262600595015 0.181468236444962 no 623 0.192625295546701 886 904970
SGTC_2682 pyrogallin 40.03 µM 0.866529522581651 0.18192551965985 no 624 0.193099921855953 1025 822798 An ATP competetive kinase inhibitor.
SGTC_1886 st057356 49.9 µM 0.86489166747688 0.182358339437389 no 625 0.193549125719372 899 24207747
SGTC_2793 7325131 81.82 µM 0.864508412720617 0.18245971119706 no 626 0.193654330454876 907 4176441
SGTC_1525 8-methoxypsoralen 92.5 µM 0.863828570358779 0.182639617641233 no 627 0.193841035266376 1017 4114 Related to psoralen; DNA damaging agent.
SGTC_524 r073-0010 27.8 µM 0.859417329975783 0.183809652119997 no 628 0.195055155976829 915 2772106
SGTC_2051 5263410 176 µM 0.857991674298331 0.184188788189099 no 629 0.195448530382668 1002 227584
SGTC_2060 5238662 140 µM 0.856820177027616 0.18450069789819 no 630 0.195772136445046 900 790130
SGTC_2312 7706453 155.7 µM 0.855353017368769 0.184891790406858 no 631 0.196177872532637 928 976098
SGTC_2227 7312221 64.1025 µM 0.854834031167912 0.18503025690747 no 632 0.196321517721247 988 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2323 6148992 148.28 µM 0.853996055109305 0.185253966456354 no 633 0.196553587583403 863 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2491 paeonol 100 µM 0.853754858005845 0.185318388547794 no 634 0.196620415725078 950 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2325 6158266 200 µM 0.853745515530503 0.185320884138648 no 635 0.196623004508435 932 3623240
SGTC_2019 4016004 108 µM 0.853643037800702 0.185348259675922 no 636 0.196651402261154 922 45595336
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.853516414117098 0.185382088945179 no 637 0.196686494565563 1006 3256 An antibiotic and ribosome inhibitor.
SGTC_1289 0976-0073 69.1 µM 0.853478127500024 0.185392318499409 no 638 0.19669710601 984 3391136
SGTC_106 0092-0003 11.579 µM 0.853145176875627 0.185481292202396 no 639 0.196789400577387 920 1072148
SGTC_167 3672-0051 66.205 µM 0.852793225957214 0.185575372124165 no 640 0.19688699057119 919 3237971
SGTC_2572 astragaloside iv 100 µM 0.852062760898468 0.185770727064653 no 641 0.197089629580508 943 45006101 An anti-inflammatory agent.
SGTC_941 3237-0776 460 µM 0.849945174778351 0.186337773011735 no 642 0.197677784060804 943 760008
SGTC_2828 7998861 71.43 µM 0.848794256428381 0.186646414544239 no 643 0.197997893348774 901 2988188
SGTC_2695 st077686 51.995 µM 0.847197617799045 0.187075108556239 no 644 0.198442490557768 951 2876092
SGTC_691 1548-0686 185 µM 0.842351256960292 0.188380071806273 no 645 0.199795684041293 986 46495133
SGTC_2927 9011802 47.9 µM 0.841932644398533 0.188493053040515 no 646 0.199912828252552 941 43912568
SGTC_2236 dapsone 200 µM 0.841230477931353 0.188682657724747 no 647 0.200109414687559 1048 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1274 0865-0114 173 µM 0.839643878603131 0.18911151689851 no 648 0.200554044621981 979 870624
SGTC_372 0155-0182 15.9 µM 0.83763337485481 0.189655819342574 no 649 0.201118321265771 1029 771486
SGTC_3271 9137798 49.47 µM 0.837380185756302 0.189724433326993 no 650 0.201189449850881 910 6498326
SGTC_682 0kpi-0099 17 µM 0.836702008871589 0.189908293764689 no 651 0.201380044841286 994 1714895 YML126C ERG13
SGTC_3106 9121286 49.47 µM 0.836483229401211 0.189967630396873 no 652 0.201441553754763 952 15943471
SGTC_2576 guaiol 23.12 µM 0.834727329061533 0.190444272465916 no 653 0.201935625309875 1023 227829
SGTC_2906 7926292 26.41 µM 0.834469047795405 0.190514445250683 no 654 0.202008361100404 1006 2966319
SGTC_1258 0671-0043 57.1 µM 0.834217694302241 0.190582751059792 no 655 0.20207916098164 999 4298767
SGTC_3105 9121040 49.47 µM 0.83415505759199 0.190599775049506 no 656 0.202096806459591 795 41448907
SGTC_158 k038-0087 26.446 µM 0.833319430720551 0.190826978809011 no 657 0.202332300297989 1012 X158
SGTC_36 0335-0881 14.2 µM 0.832218768941991 0.191126498020847 no 658 0.202642735800765 1008 23828853
SGTC_1306 1185-0270 9.02 µM 0.831051386408508 0.191444488527255 no 659 0.202972300394003 1022 1548076
SGTC_2529 gangaleoidin 93.61 µM 0.830862470870601 0.191495978850915 no 660 0.203025663349263 1000 4565183
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.83075503373037 0.191525265420517 no 661 0.203056014845318 1010 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3246 9135460 32.98 µM 0.828009155945625 0.192274702369499 no 662 0.203832657326896 941 41446951
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.826056350857142 0.192808774489538 no 663 0.204386063351486 995 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_416 estradiol valerate 100 µM 0.823237024419921 0.193581428146966 no 664 0.205186609006926 1003 13791 A steroid.
SGTC_796 1234-0020 70.7 µM 0.823024822009444 0.193639659831163 no 665 0.205246939025082 1022 46495034
SGTC_3185 9108267 49.47 µM 0.821684177380169 0.194007800700749 no 666 0.205628333354352 1030 4910486
SGTC_3248 9135562 49.47 µM 0.820968205011828 0.194204581205292 no 667 0.205832189520688 1020 17650701
SGTC_2135 5326629 150.42 µM 0.819807314290758 0.194523902951706 no 668 0.206162980357532 959 5020077
SGTC_1988 st071872 53.4 µM 0.819513863518122 0.194604671896928 no 669 0.206246647775076 1034 16414116
SGTC_1671 st016596 74.5 µM 0.816658478187538 0.195391648737414 no 670 0.207061813097998 1073 2829167
SGTC_53 0973-0023 39.979 µM 0.816438794701476 0.19545227600198 no 671 0.207124607971563 1016 674768
SGTC_3304 9125678 46.087 µM 0.815599598274038 0.195683978842898 no 672 0.207364589652846 974 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1070 indatraline 8.81 µM 0.813222526973531 0.196341194755553 no 673 0.208045243013231 1000 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.812183508792697 0.19662888366289 no 674 0.208343170416378 1105 65057 A dermal irritant. YDR527W RBA50
SGTC_1553 gossypol 38.6 µM 0.812056012744142 0.196664203031851 no 675 0.208379745878658 961 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1673 st016611 27.3 µM 0.81158631863832 0.196794352369788 no 676 0.208514522170339 1037 5226799
SGTC_1697 st025554 27.742 µM 0.811097812665487 0.196929769678694 no 677 0.208654750944201 1022 1269519
SGTC_767 0929-0023 86 µM 0.810678474389678 0.197046058197053 no 678 0.208775169014682 1093 1204563
SGTC_3270 9137563 49.47 µM 0.810252218022184 0.197164307786156 no 679 0.208897615660698 978 17015724
SGTC_837 0091-0265 12.5 µM 0.80477704332498 0.19868701411213 no 680 0.21047417568897 1025 759367
SGTC_1304 1165-0502 251 µM 0.804621886064243 0.19873026812573 no 681 0.210518954275244 1032 767425
SGTC_1235 benzylparaben 21.5 µM 0.804598262104172 0.198736854400553 no 682 0.21052577267112 975 7180
SGTC_1294 1000-1494 117 µM 0.803354021994742 0.199083930035532 no 683 0.210885070946505 1015 712797 YDL207W GLE1
SGTC_1539 benzyladenosine 56 µM 0.802899204774702 0.19921089050565 no 684 0.211016497860397 1046 92208 A nucleotide analog.
SGTC_1305 1181-0477 144 µM 0.802561253434332 0.199305259889533 no 685 0.211114185542904 1035 6252086
SGTC_2837 9008476 45.46 µM 0.802268876701254 0.199386924755421 no 686 0.211198720881036 1018 2992805
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.799042179174912 0.200289523380975 no 687 0.212132977477806 1072 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2942 9052777 62.25 µM 0.798760138380285 0.200368534677486 no 688 0.212214754120166 1093 6469503
SGTC_2516 gossypol 71.55 µM 0.798585171305773 0.200417559604217 no 689 0.212265494410296 1060 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_32 0928-0142 34.1 µM 0.797860147401739 0.200620784565324 no 690 0.212475826229953 1037 2244242
SGTC_3212 9128307 49.47 µM 0.797746048054432 0.200652777995987 no 691 0.212508937910664 916 27243542
SGTC_78 0336-0123 156.75 µM 0.79732791484135 0.200770048630164 no 692 0.212630306112942 938 6765896
SGTC_3245 9134821 49.47 µM 0.79705262033411 0.200847280834514 no 693 0.212710235754271 1048 17014901
SGTC_2455 5377712 9.75 µM 0.793134494882789 0.201948418615871 no 694 0.213849733609015 968 2243908
SGTC_2776 terbinafine 19.92 µM 0.79313079502363 0.201949460117647 no 695 0.213850811306196 1078 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_339 3091-4833 71.4 µM 0.790664798114913 0.202644347553627 no 696 0.214569811582756 1050 3240077
SGTC_2507 purpurin 79.67 µM 0.789366486670435 0.203010769183414 no 697 0.214948918736652 1076 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_688 0527-0193 473 µM 0.788297397985917 0.203312794248084 no 698 0.215261384654404 1020 4007154
SGTC_2985 9022375 71.43 µM 0.785188786320628 0.204192520942551 no 699 0.216171444591675 1117 4939335
SGTC_2671 danthron 100 µM 0.785002459673406 0.204245322673497 no 700 0.21622606323072 1044 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.783886707497204 0.204561677512015 no 701 0.216553295050406 1134 91467 include heat shock
SGTC_93 0109-0045 59.227 µM 0.783222750407061 0.204750070913166 no 702 0.216748158679744 1187 88733
SGTC_2936 9038235 15.59 µM 0.782734290003345 0.204888734162597 no 703 0.216891580802987 1082 4749415
SGTC_746 1095-0025 46.6 µM 0.782448005645209 0.204970029991376 no 704 0.216975665331882 1081 6749286
SGTC_2448 5185112 27.17 µM 0.779568605915429 0.205788755545276 no 705 0.217822420393563 1015 5718189
SGTC_879 0831-1030 162 µM 0.777259281739377 0.206446786486916 no 706 0.218502906524704 1062 1549252
SGTC_1709 st033179 39.1045 µM 0.776558107418829 0.206646829227649 no 707 0.218709762841201 1086 573381
SGTC_2128 5255449 168.493 µM 0.776409773109382 0.206689163227068 no 708 0.218753537994743 1114 736008
SGTC_937 3122-0005 46.7 µM 0.775862165584437 0.206845492621348 no 709 0.218915186907036 1093 759535
SGTC_2492 derrusnin 100 µM 0.775173555267811 0.20704217438961 no 710 0.219118556100821 998 1715307 Part of coumarin class of compounds.
SGTC_1173 0443-0020 122 µM 0.774923156170633 0.207113721127663 no 711 0.219192534083872 1061 5331295
SGTC_2204 7233102 200 µM 0.773174858031443 0.207613671195686 no 712 0.219709451737701 1023 2172480
SGTC_2620 irigenin 100 µM 0.773111305114995 0.207631858454214 no 713 0.219728255542706 1087 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3207 9114163 49.47 µM 0.772612821232521 0.207774544746288 no 714 0.219875777176543 1110 849233
SGTC_2274 7947094 46.08 µM 0.771176305828351 0.208186057488355 no 715 0.22030121823917 1116 2971028
SGTC_376 3970-0862 59.1 µM 0.769068216702736 0.208790823209639 no 716 0.220926407506281 1098 3135186
SGTC_2175 5807670 165.306 µM 0.767702973797405 0.209183033932879 no 717 0.221331834520558 1069 241186
SGTC_846 0335-0850 148 µM 0.766356214377653 0.20957035932589 no 718 0.221732189175868 1078 6819598
SGTC_209 4077-0173 175.592 µM 0.766284734133266 0.209590928687374 no 719 0.221753449849149 1005 15993494
SGTC_548 1436-0017 110 µM 0.765548648086693 0.209802815998178 no 720 0.221972454790236 1148 9677137
SGTC_3112 9123419 49.47 µM 0.765473603415834 0.209824425181982 no 721 0.221994789486878 1146 17015854
SGTC_816 0325-0417 81.3 µM 0.763454362497391 0.210406358579858 no 722 0.222596234877355 1094 68101
SGTC_808 0711-0032 135 µM 0.763353626918416 0.210435414774351 no 723 0.22262626400076 1092 4252555
SGTC_234 nsc-17383 10.7 µM 0.761746830781294 0.210899197764375 no 724 0.223105559585588 1139 408974
SGTC_1473 k844-0725 134 µM 0.760417450593393 0.211283360543198 no 725 0.223502547767529 1189 54682906
SGTC_1899 st063254 59.6 µM 0.759807794797777 0.211459675207028 no 726 0.223684741464295 1025 3093813
SGTC_2133 5320837 200 µM 0.758536740459943 0.211827545675747 no 727 0.224064863441789 1057 2841355
SGTC_955 1216-0110 33 µM 0.757587804265432 0.21210243218621 no 728 0.22434889172113 1052 3619719
SGTC_565 1418-0001 44.5 µM 0.757075895836737 0.212250807671276 no 729 0.224502197036064 1126 2862145
SGTC_2566 crystal violet carbinol 226 nM 0.756481934463638 0.212423042026486 no 730 0.224680149878686 1054 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1104 tacrolimus 29.8 µM 0.755150494083457 0.212809423915029 no 731 0.22507934446702 1127 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3065 9113888 49.47 µM 0.754960270474594 0.212864659978636 no 732 0.225136410405799 1090 16648368
SGTC_687 k029-0044 34.9 µM 0.754910348425252 0.212879157449123 no 733 0.225151388078143 1136 5829338
SGTC_464 bw-b 70c 158 µM 0.753798363025043 0.213202229748077 no 734 0.225485153542237 1132 5353454
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.752349430153919 0.21362362631423 no 735 0.22592047463174 1088 2724278 An inhibitor of dopamine biosynthesis.
SGTC_800 3448-7362 155 µM 0.752122267052899 0.213689736669624 no 736 0.225988767158729 1225 15991913
SGTC_1732 st034308 51.822 µM 0.751969072680661 0.213734326933935 no 737 0.226034828897485 1025 830119
SGTC_1144 3486-0183 12.5 µM 0.751136141071385 0.213976863040455 no 738 0.226285363571671 1114 6744069
SGTC_1739 st037196 92.5 µM 0.749648566868327 0.214410418738867 no 739 0.226733195993781 1139 612214
SGTC_2764 methyldopa 94.69 µM 0.749587474174431 0.214428235208583 no 740 0.226751598560698 1102 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1030 k029-0042 36.7 µM 0.748377068235476 0.214781403494419 no 741 0.227116375225032 1119 6080581
SGTC_2350 9023895 38.85 µM 0.745326300090825 0.215673044544812 no 742 0.228037242821072 1105 2997209
SGTC_2701 st077767 14.721 µM 0.745088373195965 0.21574267299065 no 743 0.228109148693798 1139 5721188
SGTC_637 1181-0519 7.26 µM 0.740687299206167 0.217032979264508 no 744 0.22944153098491 1165 6252091 YGR060W ERG25
SGTC_1079 idarubicin 2.36 µM 0.740344439591661 0.217133685692959 no 745 0.229545511202379 1097 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3343 9148379 18.9835 µM 0.740191699667471 0.217178557912976 no 746 0.229591841665338 1161 1955036
SGTC_1073 triclabendazole 3.09 µM 0.739913898550617 0.217260184573956 no 747 0.229676120254026 1157 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3047 9092122 49.47 µM 0.739739480200021 0.217311443196997 no 748 0.229729043698651 1114 17173831
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.739491112880488 0.217384446231531 no 749 0.229804417130466 1128 5282362
SGTC_1674 st016616 23.6 µM 0.738641725083358 0.217634215245294 no 750 0.230062290260169 1135 625830
SGTC_3127 9126946 49.47 µM 0.735730864054955 0.218491431461107 no 751 0.230947251362265 1021 27243249
SGTC_163 TUB2.036 7.546 µM 0.733316929876646 0.21920378066368 no 752 0.231682575798765 1187 15992207 YJR013W GPI14
SGTC_3075 9116269 49.47 µM 0.732769743955562 0.219365440021883 no 753 0.231849438918011 1142 17015205 YNL244C SUI1
SGTC_1380 2291-0730 164 µM 0.732191917667384 0.219536226046539 no 754 0.23202571839281 1142 2999191
SGTC_175 3793-3120 23.7 µM 0.73147584044859 0.219747980330881 no 755 0.232244278059691 1142 5322297
SGTC_573 3702-0553 84.7 µM 0.730909018305329 0.219915680865399 no 756 0.232417363587093 1120 1222756
SGTC_1388 3346-4487 254 µM 0.729979733492304 0.22019077879212 no 757 0.232701286346973 1185 3345614
SGTC_1965 Pectolinarigenin 58.4 µM 0.726488326478296 0.221226108424667 no 758 0.233769730617705 1169 5320438 An anti-inflammatory.
SGTC_2636 apigenin dimethyl ether 100 µM 0.726186714283384 0.221315677933787 no 759 0.233862157737293 1150 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2158 5657123 3.6195 µM 0.725858348716802 0.221413215945077 no 760 0.23396280627531 1131 2858827
SGTC_497 capsazepine 133 µM 0.725477130966715 0.221526484042633 no 761 0.234079684825606 1140 2733484 A calcium channel blocker.
SGTC_1171 0368-0077 21.4 µM 0.724190136950298 0.22190912256582 no 762 0.234474506455853 1125 3239779
SGTC_1879 gemcitabine 100 µM 0.723187093197425 0.222207600852829 no 763 0.234782473645462 1158 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1885 st057546 99.9 µM 0.72269644734895 0.222353686990071 no 764 0.234933199347445 1188 702008
SGTC_3168 9103419 49.47 µM 0.722457341259864 0.222424898893026 no 765 0.235006671769259 1115 16649256
SGTC_922 1866-0035 480 µM 0.721296398408434 0.222770842185412 no 766 0.235363586209268 1165 3156169
SGTC_1037 k284-1091 78.7 µM 0.72120204989287 0.222798970071841 no 767 0.235392605383251 1150 3334711
SGTC_3221 9128209 49.47 µM 0.72044448606439 0.22302489402599 no 768 0.235625684081982 1159 16460723
SGTC_2329 6138490 200 µM 0.720177758848018 0.223104469611819 no 769 0.235707777995885 1067 720019
SGTC_2481 5478948 45.16 µM 0.719429311984458 0.223327848085017 no 770 0.235938220894068 1153 77792
SGTC_2608 thymoquinone 42.66 µM 0.719290240146262 0.223369368930179 no 771 0.235981054065843 1100 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2359 9039622 200 µM 0.716379914028276 0.224239273812668 no 772 0.2368783970156 1149 6463596
SGTC_826 1683-5028 118 µM 0.713775599490499 0.225019339144849 no 773 0.237682975095655 1169 722377
SGTC_1186 1319-0216 26 µM 0.713520922357467 0.225095704554579 no 774 0.237761735559512 1214 4565136
SGTC_904 1141-0088 396 µM 0.713377531224091 0.225138707111722 no 775 0.23780608644443 1140 1378119
SGTC_1138 3761-0006 1.03 µM 0.712857128970392 0.225294813227978 no 776 0.237967084997104 1166 12061087
SGTC_1968 st069590 43.6 µM 0.711647209464345 0.225657992055906 no 777 0.238341632625282 1135 6384066
SGTC_829 1635-0120 117 µM 0.711505629058055 0.225700511567098 no 778 0.238385481925677 1200 285054
SGTC_2648 atorvastatin 78.68 µM 0.704933210543401 0.227679326555625 no 779 0.240425900715731 1192 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1286 0929-0070 131 µM 0.704564144527366 0.227790733319326 no 780 0.240540759297511 1223 1420408
SGTC_3155 9099265 49.47 µM 0.701321470924773 0.228770889024045 no 781 0.241551208639732 1129 25236499
SGTC_522 1273-0010 11.6 µM 0.701184390685132 0.228812376056734 no 782 0.241593974925442 1248 5705015
SGTC_1830 st055982 50.3 µM 0.70049156354795 0.229022123264697 no 783 0.241810185982864 1144 455313 An antimicrobial agent.
SGTC_2278 7948257 134.34 µM 0.69899637685113 0.229475145026205 no 784 0.242277147554322 1171 1247028
SGTC_828 2074-0507 139 µM 0.696775895226397 0.230148847248427 no 785 0.242971526769884 1221 X828
SGTC_362 0310-0100 9.03 µM 0.696363901094896 0.230273969354953 no 786 0.243100482060119 1208 790235
SGTC_2281 7943571 200 µM 0.694449329192821 0.23085592135594 no 787 0.243700233639145 1251 1244024
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.694235447684243 0.23092098359667 no 788 0.243767282924619 1175 15053
SGTC_2324 6149169 200 µM 0.693336348201208 0.23119459944501 no 789 0.244049248700442 1129 2888231
SGTC_2134 5324836 1.464 µM 0.690601973056913 0.232027840825368 no 790 0.2449078536042 1158 699272
SGTC_2708 st078559 56 µM 0.690386956290126 0.232093433341552 no 791 0.244975438611508 1135 17250902
SGTC_2511 berberine 10.47 µM 0.68980345045994 0.232271488279634 no 792 0.245158899262398 1206 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2740 felodipine 17.08 µM 0.68889968387115 0.232547419727366 no 793 0.245443199196301 1160 3333 L-type calcium channel blocker
SGTC_1980 st071811 45.7 µM 0.688640711553042 0.232626520856214 no 794 0.245524697356749 1244 4974850
SGTC_473 2-arachidonoylglycerol 10 µM 0.688426919861956 0.232691833174479 no 795 0.245591988201629 1166 5282280 An endocannabinoid.
SGTC_2262 9014885 67.46 µM 0.688266085661068 0.232740973954817 no 796 0.245642617227139 1150 6457424
SGTC_2225 6654152 15.4 µM 0.688233596863347 0.232750901180906 no 797 0.245652845061771 1172 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2020 4017018 200 µM 0.688208483558922 0.23275857492407 no 798 0.245660751165849 1225 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2247 cerulenin 830 nM 0.687682441445 0.232919347217803 no 799 0.245826389757315 1260 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2975 9084847 53.72 µM 0.683695247320413 0.234139942125076 no 800 0.247083812616818 1205 27211724
SGTC_334 1502-1024 68.5 µM 0.683136416963578 0.234311298733639 no 801 0.247260322842576 1244 3296216
SGTC_3325 9138760 55.175 µM 0.683087277522705 0.234326369895781 no 802 0.24727584708078 1208 43844959
SGTC_1941 st076221 61.8 µM 0.681211065191456 0.234902209016338 no 803 0.247868973729164 1217 2828568
SGTC_375 3970-0961 9.27 µM 0.679667877900802 0.235376423036399 no 804 0.248357389827046 1183 2898222
SGTC_3123 9126162 49.47 µM 0.679562068321882 0.235408957156134 no 805 0.248390897158492 1275 25239884
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.679246078030774 0.235506131996764 no 806 0.248490977973131 1194 689007
SGTC_1738 st035555 74 µM 0.679066327509465 0.235561419608581 no 807 0.248547918355036 1231 5331140
SGTC_2015 5119600 184 µM 0.678822190803259 0.235636522569888 no 808 0.248625265769629 1219 2828786
SGTC_1835 st008666 49.2 µM 0.67825508631086 0.235811029996463 no 809 0.248804985340108 1163 690455
SGTC_720 r052-1644 49.9 µM 0.677992251662223 0.235891932720153 no 810 0.248888303016818 1207 1422863 YOR257W CDC31
SGTC_1483 3453-0561 55.9 µM 0.677700279268348 0.235981822222774 no 811 0.248980874667011 1225 4546991
SGTC_3252 9135871 49.47 µM 0.677444416212274 0.236060610264877 no 812 0.249062012689529 1254 17682838
SGTC_2453 5731132 22.18 µM 0.67735171003857 0.236089160901127 no 813 0.249091414682722 1269 1362040
SGTC_1012 4112-3522 18 µM 0.675121681031172 0.236776513886397 no 814 0.249799229988643 1229 3112398
SGTC_1708 st033234 31.827 µM 0.674888147986343 0.236848558453759 no 815 0.249873415527344 1279 674664
SGTC_3354 9151612 71.43 µM 0.674490759476595 0.23697117986789 no 816 0.249999679274407 1222 27261949
SGTC_1164 k060-0068 93.7 µM 0.674391301836595 0.23700187478069 no 817 0.250031285620922 1256 5963676
SGTC_736 0958-0254 92.6 µM 0.673128398289616 0.237391825812791 no 818 0.250432804283313 1274 6812352
SGTC_2899 9053889 58.44 µM 0.67312839323883 0.237391827373044 no 819 0.250432805889807 1198 6470052
SGTC_2623 humulene 100 µM 0.670547079622303 0.238189963108672 no 820 0.251254552464694 1179 6187145 An anti-inflammatory.
SGTC_662 k832-1615 104 µM 0.668779913344109 0.238737213186803 no 821 0.251817940920856 1235 5878478
SGTC_1713 st033146 12.748 µM 0.667961184204911 0.238990987445597 no 822 0.252079185006382 1250 674619
SGTC_1067 clotrimazole 1.36 µM 0.666936416994626 0.239308833232708 no 823 0.252406374091484 1258 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1901 st060216 58.6 µM 0.66490494519484 0.239939604490681 no 824 0.253055646281706 1247 688792
SGTC_1523 st012844 44.7 µM 0.662594867847023 0.240657983055264 no 825 0.253795028989972 1274 4274103
SGTC_654 1124-0271 80.9 µM 0.660469044837588 0.241320095982529 no 826 0.254476438458758 1250 5403748
SGTC_2161 5662504 8.5105 µM 0.660290462364415 0.241375762655839 no 827 0.254533724746328 1227 2859334
SGTC_2435 5706476 10.6 µM 0.660227834947033 0.241395286156439 no 828 0.254553816180318 1272 5725375
SGTC_1562 morin hydrate 59.1 µM 0.660185935417029 0.241408348414611 no 829 0.254567258387022 1273 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1676 st018489 23.4 µM 0.658899528639991 0.241809574976103 no 830 0.254980144288334 1267 3696235
SGTC_2781 5567276 71.43 µM 0.658695493948636 0.241873246040048 no 831 0.255045663566365 1253 2853274
SGTC_1495 4469-0029 237 µM 0.658149538852975 0.242043661506446 no 832 0.255221023054478 1262 793680
SGTC_1731 st035964 63 µM 0.658136526246901 0.242047724080491 no 833 0.2552252034419 1258 6739575
SGTC_1285 0929-0069 65.5 µM 0.657535321289929 0.242235462359002 no 834 0.255418383618307 1252 1206237
SGTC_232 clozapine 119 µM 0.65725971790501 0.242321551407842 no 835 0.255506966491727 1236 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1158 4092-0494 91.8 µM 0.65695271671568 0.242417467571746 no 836 0.255605659962872 1334 1148199
SGTC_64 000l-0018 272.079 µM 0.656501201444608 0.242558571530206 no 837 0.255750847389886 1212 6811119
SGTC_3223 9129970 49.47 µM 0.655307256465663 0.242931907932365 no 838 0.256134974865705 1311 17248386
SGTC_3347 9188721 44.724 µM 0.655237054065941 0.242953869296356 no 839 0.256157570419732 1243 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2905 7799065 20.05 µM 0.65397405811586 0.243349154785965 no 840 0.256564259566935 1211 1296806
SGTC_231 b-estradiol 524 µM 0.653532749509093 0.243487355005032 no 841 0.25670644173725 1204 450 A steroid.
SGTC_3319 9138450 16.7555 µM 0.653188503114781 0.243595188647059 no 842 0.256817380578915 1243 2029690
SGTC_236 1509-0011 5.31 µM 0.652707288910063 0.243745970056739 no 843 0.256972501273218 1325 3107280
SGTC_2126 5251174 33.877 µM 0.652691745288464 0.243750841262322 no 844 0.256977512614022 1303 790722
SGTC_1225 1216-0074 20.6 µM 0.652350739008138 0.243857722223199 no 845 0.257087467524035 1259 4241466
SGTC_1291 0993-0025 5.79 µM 0.651691308885065 0.244064477896808 no 846 0.257300165192533 1283 4353356
SGTC_1560 lithocholic acid 53.1 µM 0.651622909907309 0.24408592891078 no 847 0.257322232359627 1219 9903 A bile acid which acts as a detergent.
SGTC_1694 st024011 44.9 µM 0.649476905457419 0.244759466378644 no 848 0.258015084601791 1319 2787533
SGTC_2123 5259487 200 µM 0.648218687403193 0.245154831108332 no 849 0.258421758427627 1243 2173474
SGTC_2280 7785178 200 µM 0.648025488191075 0.245215569710824 no 850 0.258484232535024 1273 2954328
SGTC_1700 st030840 7.9285 µM 0.647859484772836 0.245267764872544 no 851 0.258537918688206 1293 5499307
SGTC_3021 9087658 49.47 µM 0.647405204024082 0.245410631361259 no 852 0.258684864373586 1257 25237042
SGTC_2907 7721985 69.9 µM 0.645419224339078 0.246035725712893 no 853 0.25932777428725 1235 3267881
SGTC_735 3076-0345 636 µM 0.643864902484632 0.246525549415541 no 854 0.259831521376978 1316 2888990
SGTC_1279 0874-0590 65.2 µM 0.643837962936018 0.246534043656879 no 855 0.259840256784083 1307 3523074
SGTC_2073 5212005 126 µM 0.641394198450468 0.247305232721951 no 856 0.260633300667387 1179 691789
SGTC_672 1441-0018 53.7 µM 0.640552838952749 0.247571042223097 no 857 0.260906624408314 1253 251141
SGTC_2534 helenine 20.12 µM 0.639502127840576 0.247903206076055 no 858 0.261248164924394 1302 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2443 5493264 126.67 µM 0.639457065048634 0.247917457203325 no 859 0.261262818015105 1294 5340055
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.639345995394575 0.24795258489594 no 860 0.261298936393284 1257 6312947
SGTC_1861 st057647 17.4 µM 0.638609667949877 0.248185528299233 no 861 0.261538445163784 1359 688668
SGTC_2560 caryophyllene 100 µM 0.637879212055661 0.248416729456684 no 862 0.26177615537286 1317 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_350 k064-0020 19.8 µM 0.637669740750773 0.248483051700545 no 863 0.26184434347436 1305 2790705
SGTC_999 SEC7.066 22.7 µM 0.637256281625311 0.248613987709188 no 864 0.261978961398817 1307 740511 YDR170C SEC7
SGTC_2664 lyso-paf C-16 73.48 µM 0.636558916453495 0.248834915546953 no 865 0.262206096500683 1290 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_457 grayanotoxin iii 135 µM 0.635913134358161 0.249039594843972 no 866 0.262416520691495 1247 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_435 c-PAF 6.7 µM 0.635540533690584 0.249157730592227 no 867 0.262537969690021 1251 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1726 st035556 14.5795 µM 0.633630867549221 0.249763671674534 no 868 0.263160875662866 1373 5919439
SGTC_1393 3470-5649 58.2 µM 0.633123829232195 0.249924687355954 no 869 0.26332639112287 1236 4108395
SGTC_3196 9111891 49.47 µM 0.631514237366312 0.250436196054474 no 870 0.263852171529911 1287 18891510
SGTC_1050 3232-1156 69.3 µM 0.630330179222518 0.250812829214608 no 871 0.264239290838848 1275 700529
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.63006425282934 0.250897458085273 no 872 0.264326273321764 1329 279621
SGTC_2945 9067681 61.76 µM 0.628428833245384 0.251418248936063 no 873 0.264861526823771 1364 16456930
SGTC_692 k241-0027 77.8 µM 0.628287495957613 0.251463283866525 no 874 0.264907810698409 1366 3600480
SGTC_20 0481-0013 4.944 µM 0.627991074932653 0.25155774766397 no 875 0.265004893361163 1276 182045
SGTC_668 1682-0499 62.6 µM 0.626374373570195 0.252073289733702 no 876 0.265534707080744 1328 682214
SGTC_110 0850-0284 111.64 µM 0.625665919659436 0.252299380689941 no 877 0.26576704569395 1168 3906265
SGTC_585 0kpi-0023 191 µM 0.625532616868702 0.252341933944985 no 878 0.26581077407778 1289 64601
SGTC_2084 5306078 60.6385 µM 0.62528780581994 0.252420093002495 no 879 0.265891090907335 1279 679340
SGTC_1362 1611-0397 101 µM 0.624606846064853 0.252637565197147 no 880 0.266114562674024 1290 27816
SGTC_1170 0310-0127 64.8 µM 0.624432899607939 0.252693132784338 no 881 0.266171662237014 1318 774975
SGTC_569 4130-2812 160 µM 0.622100956158938 0.253438698477951 no 882 0.266937743149249 1245 743552
SGTC_3199 9111318 49.47 µM 0.621494101548626 0.253632910577404 no 883 0.267137287119555 1303 8548020
SGTC_2782 7736369 71.43 µM 0.621260423576211 0.253707715539985 no 884 0.267214144430296 1342 2950836 YOL077C BRX1
SGTC_2476 5806916 10.51 µM 0.619944920888217 0.254129050191216 no 885 0.267647024938731 1242 2870194
SGTC_1813 st051246 8.6015 µM 0.61933863234805 0.254323358272264 no 886 0.267846649718505 1270 5291959
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.618033885443232 0.254741777731931 no 887 0.268276501062734 1326 551469
SGTC_2869 9037858 32.47 µM 0.617094471442722 0.255043261559987 no 888 0.268586207528401 1266 27187042
SGTC_211 3455-0679 143.504 µM 0.616192553751391 0.255332887320597 no 889 0.268883721176405 1333 748649
SGTC_151 3013-0144 2.285 µM 0.616051064035231 0.255378338399455 no 890 0.268930409096539 1362 906558 YHR107C CDC12
SGTC_2508 celastrol 40.54 µM 0.614258457960008 0.255954547468446 no 891 0.269522274613365 1264 122724 Celastrol is a natural product and antioxidant.
SGTC_249 wiskostatin 11.211 µM 0.613409511392987 0.256227666410739 no 892 0.269802799267792 1326 2775510 A n-wasp and actin depolymerizer.
SGTC_1465 k213-0056 144 µM 0.613395830588225 0.256232068976086 no 893 0.269807321129478 1275 24048857 YMR208W ERG12
SGTC_3119 9125183 49.47 µM 0.612446181167925 0.256537768233948 no 894 0.270121297662913 1195 22695334
SGTC_2439 5492030 7.2 µM 0.611844692288008 0.256731490232486 no 895 0.270320258595643 1293 5722370
SGTC_67 0335-0847 266 µM 0.611064091137991 0.256983012566133 no 896 0.270578575603247 1482 4552207 YOR254C SEC63
SGTC_2669 eugenol 100 µM 0.610757081638966 0.257081971111557 no 897 0.270680205147281 1314 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2704 st078022 71.1 µM 0.609638406801714 0.257442721806901 no 898 0.271050681965287 1375 54697681
SGTC_1568 digitonin 820 nM 0.609554095772035 0.257469921114267 no 899 0.271078613892153 1371 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1609 st001574 46.4 µM 0.607857844690742 0.25801746014798 no 900 0.271640880293226 1298 3960012
SGTC_2373 9071805 200 µM 0.607495723592975 0.258134428708728 no 901 0.271760989886882 1367 10149009
SGTC_2684 capsaicin 100 µM 0.606482291294308 0.25846192306551 no 902 0.272097269089914 1312 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1163 k060-0048 49.9 µM 0.606319108050664 0.258514676438797 no 903 0.272151436223078 1329 6809982
SGTC_1455 4262-0120 131 µM 0.606235589111041 0.258541678340085 no 904 0.272179161618152 1397 1529587
SGTC_2989 9073649 71.4286 µM 0.606098913315223 0.258585869148848 no 905 0.272224536276614 1312 21367202
SGTC_56 0957-0365 83.25 µM 0.605490760310086 0.258782548105524 no 906 0.272426481051502 1283 6752360
SGTC_626 0214-0009 33 µM 0.604796217759516 0.259007260421581 no 907 0.272657203521843 1405 3437874
SGTC_1851 st056236 18.9 µM 0.60451958718902 0.259096789577365 no 908 0.272749125376554 1358 5393171
SGTC_1742 st038235 28.8875 µM 0.602507244481478 0.259748548594896 no 909 0.273418271185164 1343 564103 YBR002C RER2
SGTC_2544 sphondin 68.51 µM 0.60218830334433 0.259851925103374 no 910 0.273524400320066 1373 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1209 2323-2347 50.3 µM 0.601589567496964 0.260046047128059 no 911 0.273723687484809 1324 5412760
SGTC_2452 5863136 48.41 µM 0.601118747432825 0.260198748822199 no 912 0.273880448749525 1309 2184096
SGTC_477 mead ethanolamide 10 µM 0.600603635249687 0.260365868761227 no 913 0.274052008067186 1237 16061185
SGTC_1360 1598-0022 39.8 µM 0.600576096323391 0.260374804883803 no 914 0.274061181466149 1414 761525
SGTC_1863 st057641 20.1 µM 0.599702001242506 0.260658522583039 no 915 0.27435242714419 1328 3921635
SGTC_2549 cedrol 20.94 µM 0.599665398744695 0.260670406655901 no 916 0.274364626311316 1372 6708665 A sedative which affects the nervous system.
SGTC_1441 4106-0040 13 µM 0.599258904235275 0.260802405745704 no 917 0.274500123981883 1326 2904180
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.599074728255547 0.260862223681387 no 918 0.274561526616368 1363 5379071
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.596704496449701 0.261632673128069 no 919 0.275352345017339 1324 279621
SGTC_729 4092-0585 94.1 µM 0.595927983787138 0.261885334128207 no 920 0.275611668920359 1308 2169061
SGTC_916 4466-0038 42 nM 0.594533902883606 0.262339252702513 no 921 0.276077536813658 1390 5722064 YGL116W CDC20
SGTC_2255 7941087 197.44 µM 0.592106906612764 0.263130453073527 no 922 0.276889501155829 1409 935561
SGTC_948 3448-0295 75.3 µM 0.591275826427814 0.26340166503029 no 923 0.27716781193328 1356 678569
SGTC_131 0141-0277 33.849 µM 0.590883623466257 0.263529704794806 no 924 0.277299199740034 1380 1547771
SGTC_2090 5301565 104.445 µM 0.590301135306809 0.263719924240124 no 925 0.277494389192184 1380 2056344
SGTC_2690 usnic acid 100 µM 0.588943181724579 0.264163654259037 no 926 0.277949694590244 1464 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.587454442755199 0.264650556826638 no 927 0.278449269320172 1325 803109
SGTC_3018 9082602 49.47 µM 0.587257938192432 0.264714859113106 no 928 0.278515242841513 1351 17332089
SGTC_1425 4048-4433 7.33 µM 0.586680418603823 0.264903887113521 no 929 0.278709180626363 1391 23734946
SGTC_1724 st037281 8.293 µM 0.585112397130031 0.265417462155478 no 930 0.279236071783877 1358 574124 YDL195W SEC31
SGTC_633 0437-0093 97.7 µM 0.584012088740554 0.265778148271552 no 931 0.279606089430923 1364 2831118
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.583716970996147 0.265874931455653 no 932 0.279705373684087 1334 4174840
SGTC_3166 9102297 49.47 µM 0.5836222565141 0.265905996637048 no 933 0.279737241394091 1309 25237072
SGTC_1245 0418-0076 17.2 µM 0.58215450815181 0.266387634955046 no 934 0.280231306229108 1390 6790114
SGTC_1948 st076329 66.6 µM 0.579793282759834 0.267163390889165 no 935 0.281027013984091 1294 24208413
SGTC_756 0508-1999 28.3 µM 0.578658996779728 0.267536453754175 no 936 0.281409644039728 1321 6753853
SGTC_2871 9038510 12.99 µM 0.577388500435115 0.267954627389748 no 937 0.2818385203776 1465 4945164
SGTC_848 0368-0089 85.6 µM 0.574490955274034 0.268909560732299 no 938 0.282817809682271 1329 762535
SGTC_3308 9128332 17.569 µM 0.571605071547219 0.269862346275719 no 939 0.283794779413989 1462 17332805 YDL196W YDL196W
SGTC_1960 st011366 51.8 µM 0.571249209044341 0.269979952584803 no 940 0.283915362786686 1382 3972846
SGTC_1675 st018485 24.5 µM 0.570891977001552 0.270098037294676 no 941 0.284036434882646 1402 3323024
SGTC_2358 9037157 4 µM 0.570259567834135 0.270307146418174 no 942 0.284250829795378 1418 2388925
SGTC_1421 4029-0249 71.4 µM 0.569505219049156 0.270556681264923 no 943 0.284506664952659 1468 2894095
SGTC_1248 0469-0687 58.6 µM 0.569215180432667 0.270652655224129 no 944 0.284605059955667 1429 4017482
SGTC_683 panaxydol 45 µM 0.568582158162134 0.270862181719673 no 945 0.284819867870966 1360 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1488 4013-0813 75.9 µM 0.56837002386335 0.270932414979202 no 946 0.284891870201818 1360 2910057
SGTC_1253 0550-0034 176 µM 0.568335720047807 0.270943773113373 no 947 0.284903514371072 1381 5969915
SGTC_2857 9024691 58.44 µM 0.56759458202003 0.271189224958064 no 948 0.285155143457795 1403 16478292
SGTC_2755 lomerizine 42.69 µM 0.567504765173785 0.27121897824354 no 949 0.285185645014007 1371 3949 A calcium channel blocker.
SGTC_982 1491-0518 27.5 µM 0.567381241946168 0.27125989997181 no 950 0.285227595704869 1356 3091256
SGTC_2320 7373003 200 µM 0.566763841133902 0.271464483402708 no 951 0.285437320096939 1341 5415828
SGTC_3261 9137475 49.47 µM 0.56603186908675 0.271707130975389 no 952 0.285686058191237 1334 17027690
SGTC_2463 5473429 200 µM 0.565535804469842 0.271871636962919 no 953 0.285854689036654 1391 5399405
SGTC_3277 9138724 49.47 µM 0.565328343659992 0.271940450243696 no 954 0.285925226728567 1349 15943418
SGTC_3087 9117406 49.47 µM 0.564079201265405 0.272354964961362 no 955 0.286350116068205 1361 42546093
SGTC_1323 1348-1351 11.2 µM 0.56140285647255 0.273244137070083 no 956 0.287261468595115 1387 6989654
SGTC_983 1491-0821 12.2 µM 0.556764723895631 0.274788478970231 no 957 0.288844094340376 1423 46495113
SGTC_1821 st053465 65.6 µM 0.556166921860374 0.274987839508219 no 958 0.28904837483129 1360 675086
SGTC_2304 7443016 91.4 µM 0.554894086331265 0.275412553684055 no 959 0.289483553526534 1381 939854
SGTC_1252 0493-0875 34.8 µM 0.553742100699327 0.275797221220279 no 960 0.289877679080331 1394 3960963
SGTC_3030 9087619 49.47 µM 0.553105773931086 0.276009814653875 no 961 0.290095491590107 1366 25236973
SGTC_1329 1447-1697 50.6 µM 0.553058755042441 0.276025526610079 no 962 0.290111589040167 1395 2840515
SGTC_18 0111-0177 500 nM 0.552852678289798 0.276094394943247 no 963 0.290182146692436 1438 721752
SGTC_2408 sulbentine 18.36 µM 0.551587332369977 0.276517442914372 no 964 0.290615558690139 1498 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3259 9138485 49.47 µM 0.55137019238768 0.276590072095798 no 965 0.29068996489061 1504 17646153
SGTC_308 4092-1169 104 µM 0.550112692230084 0.277010865689897 no 966 0.291121040878276 1422 2268590 YDL196W YDL196W
SGTC_812 4251-0442 148 µM 0.549455576488621 0.277230878998928 no 967 0.291346421432734 1398 5723007
SGTC_2865 9030313 51.95 µM 0.549140863322064 0.277336280479275 no 968 0.291454392018753 1355 42562754
SGTC_781 4335-2806 94.4 µM 0.547882121889852 0.277758044964715 no 969 0.291886422709581 1530 845254
SGTC_1181 1222-0449 220 µM 0.545936233582379 0.278410666393545 no 970 0.292554885274945 1462 658318
SGTC_1068 loratadine 26.9 µM 0.544667796957188 0.278836482720045 no 971 0.292991008440439 1403 3957 A H1 histamine antagonist.
SGTC_947 3447-0010 211 µM 0.544021526988744 0.279053558451573 no 972 0.293213329649395 1409 748350
SGTC_1034 k072-0165 12.7 µM 0.543806875587297 0.279125675924357 no 973 0.293287188471372 1511 5835461
SGTC_2151 5563267 85.4165 µM 0.543183372898885 0.279335208520336 no 974 0.293501776717423 1419 5310824
SGTC_3346 9158254 43.5805 µM 0.542701022601302 0.279497358242766 no 975 0.293667835021068 1413 17639500
SGTC_961 1252-1571 372 µM 0.542692890460439 0.27950009238297 no 976 0.293670635038635 1525 6813498
SGTC_3183 9108214 49.47 µM 0.542105172087349 0.279697725951047 no 977 0.293873027962955 1370 4974831
SGTC_3027 9089541 49.47 µM 0.53916047449079 0.280688966818575 no 978 0.294888065317615 1405 9943819
SGTC_835 0312-0010 67.2 µM 0.538418531502052 0.28093898659431 no 979 0.29514406771056 1405 1626196
SGTC_1310 1188-0297 994 nM 0.527785991032079 0.284533711046831 no 980 0.29882394070407 1431 1588352
SGTC_3290 9121031 71.43 µM 0.527182654267239 0.284738348279503 no 981 0.299033376477932 1411 17014854
SGTC_193 1273-0060 1.558 µM 0.526458505097131 0.284984054868188 no 982 0.299284837726555 1372 2847393 YHR072W ERG7
SGTC_2238 6671620 73.2395 µM 0.525783136204618 0.28521330120716 no 983 0.299519446408532 1383 729941
SGTC_1446 4239-0190 62 µM 0.525485176604031 0.28531446815552 no 984 0.299622977683405 1423 1340085
SGTC_1656 st012921 11 µM 0.52514764093568 0.285429093108752 no 985 0.299740279939313 1466 6732821
SGTC_84 0443-0269 128.823 µM 0.524774032929543 0.285555993559875 no 986 0.299870142499031 1416 6150058
SGTC_598 3937-0236 20.2 µM 0.524478840188542 0.285656278310692 no 987 0.299972766672877 1485 1379313
SGTC_1053 3366-3204 134 µM 0.523540743989567 0.285975085500201 no 988 0.300299002596063 1397 3632071 YPR165W RHO1
SGTC_2153 5569715 200 µM 0.522957161189647 0.286173498414897 no 989 0.300502032457141 1470 2054701
SGTC_2960 9079389 5.97 µM 0.521337971965867 0.286724350344119 no 990 0.301065676639741 1546 16457355
SGTC_1271 0832-2808 169 µM 0.520710090308506 0.286938092321177 no 991 0.301284372093377 1510 3663794
SGTC_597 k018-0003 82.8 µM 0.519977705613467 0.287187504310102 no 992 0.301539557018785 1547 6786234
SGTC_2023 5144124 124 µM 0.518824991074579 0.28758026643376 no 993 0.301941394388759 1438 2830192
SGTC_484 loperamide 105 µM 0.517743153993624 0.28794910944754 no 994 0.302318742493869 1446 3955 An opioid-receptor agonist.
SGTC_2763 lisinopril 49.32 µM 0.515588290511514 0.288684456322703 no 995 0.303070995146565 1428 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1632 st005650 90 µM 0.51531073981402 0.288779234715716 no 996 0.3031679476277 1474 2759605
SGTC_671 0560-0003 407 µM 0.514588037120008 0.289026092934807 no 997 0.303420463205343 1491 3238678
SGTC_2912 7964298 10.93 µM 0.514380188531231 0.289097107492585 no 998 0.303493103834122 1465 2975850
SGTC_2195 6536160 144.242 µM 0.514008983653616 0.289223955562894 no 999 0.303622854878003 1367 3834386
SGTC_122 0236-0016 402.397 µM 0.51211995753789 0.289869878259645 no 1000 0.304283528843822 1488 6808838
SGTC_3350 9150499 3.57 µM 0.510444145887192 0.290443461373004 no 1001 0.304870167824745 1420 4910996 YPR165W RHO1
SGTC_1003 4049-0218 100 µM 0.508234575311072 0.29120054617338 no 1002 0.305644422990053 1526 295161
SGTC_2859 9028643 45.46 µM 0.507826056485296 0.291340621467824 no 1003 0.305787667360936 1449 17151580
SGTC_442 cape 100 µM 0.507674848636232 0.29139247646032 no 1004 0.305840694910375 1570 5281787
SGTC_647 0140-0236 81 µM 0.506629089273151 0.291751225427336 no 1005 0.306207546888334 1509 990837
SGTC_2445 5742597 35.57 µM 0.506493288095133 0.291797827274424 no 1006 0.306255200157566 1425 1774255
SGTC_1921 5740136 50 µM 0.503577450770111 0.292799268390248 no 1007 0.30727917080979 1591 1774243
SGTC_48 0382-0018 55 µM 0.503081098124635 0.292969898968995 no 1008 0.307453627746954 1603 762596
SGTC_1440 4100-1550 40 µM 0.502380099217593 0.293210959122404 no 1009 0.307700087511204 1489 742806
SGTC_38 0929-0051 58.268 µM 0.502135505097292 0.293295092010558 no 1010 0.307786103242362 1566 1379719
SGTC_1832 st054113 55 µM 0.501934611463839 0.293364201636968 no 1011 0.307856758847795 1488 1251267
SGTC_865 0488-0499 301 µM 0.498761510141836 0.294456782927772 no 1012 0.308973702983425 1486 9634651
SGTC_2010 4012422 159 µM 0.497763484377624 0.294800817024513 no 1013 0.309325378094444 1537 952393
SGTC_2649 anisomycin 9.56 µM 0.490472022244468 0.297319894267109 no 1014 0.311899961426495 1462 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3226 9131256 49.47 µM 0.49045980812328 0.297324122279937 no 1015 0.311904281946716 1411 17178073
SGTC_1398 3558-0053 112 µM 0.487404744276889 0.298382517879824 no 1016 0.312985766060129 1468 4532369
SGTC_355 1311-2252 105 µM 0.480951508878486 0.300623792296425 no 1017 0.315275481451191 1471 5338538
SGTC_2076 5212012 200 µM 0.479544621883697 0.301113425758807 no 1018 0.315775615939392 1481 604802
SGTC_99 0109-0120 622.8 µM 0.477333370332455 0.301883724483596 no 1019 0.316562375997465 1588 759414
SGTC_101 0490-5701 117.494 µM 0.477228172665208 0.301920392585855 no 1020 0.316599825900644 1563 4661669
SGTC_3020 9089140 49.47 µM 0.474888315440833 0.30273649885375 no 1021 0.317433290105574 1518 17217859
SGTC_2071 5230951 39.92 µM 0.474751918182376 0.302784102587923 no 1022 0.317481903837477 1516 1799272
SGTC_1435 4092-0789 56.7 µM 0.473344343704151 0.303275553004519 no 1023 0.317983765174989 1600 2248285
SGTC_1622 st003707 19.4 µM 0.473063942908413 0.303373496679931 no 1024 0.318083780195184 1549 10140899
SGTC_90 0870-0863 4.608 µM 0.47233208208667 0.303629201388553 no 1025 0.318344887148344 1483 1738164
SGTC_2398 5228213 48.84 µM 0.472219225852793 0.303668640767057 no 1026 0.318385159052635 1653 80771 YMR134W ERG29
SGTC_2988 9073640 71.4286 µM 0.467774861213251 0.30522360788426 no 1027 0.319972799844483 1566 9102229
SGTC_130 0136-0219 337.655 µM 0.466868982916392 0.305540984052162 no 1028 0.32029680891716 1563 234244
SGTC_590 k048-0076 22.4 µM 0.466327636935796 0.305730715431843 no 1029 0.320490499714763 1599 6832814
SGTC_811 0416-0114 265 µM 0.466140800161727 0.305796210247268 no 1030 0.320557360301872 1534 6612453
SGTC_3136 9095672 49.47 µM 0.465842230006678 0.305900885606154 no 1031 0.320664217393375 1545 17217380
SGTC_3053 9095903 49.47 µM 0.464945453228227 0.306215380830806 no 1032 0.320985259633701 1583 17174018
SGTC_905 2-aminofluorene 215 µM 0.464506175245954 0.306369485609029 no 1033 0.321142568134252 1524 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3088 9117578 49.47 µM 0.461816244829201 0.307313896656673 no 1034 0.322106550191499 1549 678341
SGTC_636 0kpi-0074 126 µM 0.461567817335235 0.307401181993761 no 1035 0.322195638911502 1522 616434
SGTC_771 0250-0039 27.3 µM 0.459777959189906 0.308030373267994 no 1036 0.32283780261042 1546 3005115
SGTC_1374 2889-5571 141 µM 0.459754643188325 0.308038573303512 no 1037 0.322846171396392 1520 2853281
SGTC_1852 st056254 31.4 µM 0.459587354365473 0.308097410141787 no 1038 0.32290621881433 1587 442583
SGTC_2502 avocadyne acetate 18.59 µM 0.459508099454912 0.308125286459727 no 1039 0.322934668547559 1493 3952079
SGTC_76 0433-0009 400.328 µM 0.459281209509143 0.30820509654646 no 1040 0.323016119808846 1544 2841569
SGTC_669 0108-0021 26.2 µM 0.45766427934166 0.308774125179515 no 1041 0.323596827446185 1816 17201
SGTC_1810 st050138 53 µM 0.457632597848995 0.30878527909532 no 1042 0.323608209900821 1582 3444541
SGTC_929 2805-0021 398 µM 0.45745752140258 0.308846920404914 no 1043 0.323671113943942 1591 3098024
SGTC_1442 4112-3290 3 µM 0.45730956761254 0.308899016506766 no 1044 0.323724276887726 1526 704353
SGTC_1290 0986-0249 10.2 µM 0.457135278129607 0.308960390618175 no 1045 0.323786907420653 1516 53329
SGTC_2163 5671233 125 µM 0.457110631906587 0.308969069943191 no 1046 0.323795764388115 1640 701023
SGTC_1262 0737-0114 49.6 µM 0.456429809806534 0.309208867951795 no 1047 0.324040466835703 1584 765919
SGTC_2074 5212007 75.395 µM 0.456130307414965 0.309314383933082 no 1048 0.324148138679761 1625 758611
SGTC_2739 tacrine 100.86 µM 0.4542590562439 0.309973989582607 no 1049 0.324821190828414 1548 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_489 paxilline 115 µM 0.45307527075955 0.310391583642783 no 1050 0.325247270816061 1494 105008 A toxic potassium channel blocker.
SGTC_1661 st013063 9.66 µM 0.452766036156305 0.310500710040224 no 1051 0.325358611322029 1564 721395
SGTC_2932 9016711 44.54 µM 0.452416646472865 0.310624026911233 no 1052 0.32548442849844 1681 7117328
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.451408708366583 0.310979897255448 no 1053 0.325847504049899 1544 4620898
SGTC_1443 4112-3303 14 µM 0.451252039214996 0.311035227952799 no 1054 0.325903953648504 1549 704433
SGTC_87 0100-0052 35.5 µM 0.450828067684182 0.311184982998726 no 1055 0.326056735210913 1613 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_404 fumagillin 50 µM 0.450154389915317 0.311423003471154 no 1056 0.326299560494454 1562 12015870 A methionine aminopeptidase binder.
SGTC_856 0433-0016 11.3 µM 0.449347200335013 0.31170829950134 no 1057 0.326590606723366 1557 3911780
SGTC_1013 4112-3890 241 µM 0.444218210337299 0.313523744091267 no 1058 0.328442413789524 1521 705171
SGTC_1866 st057638 64 µM 0.443162938493465 0.313897828388824 no 1059 0.328823941869145 1569 688802
SGTC_988 1497-1057 103 µM 0.442153332440524 0.314255903713846 no 1060 0.329189126771589 1642 3533044
SGTC_430 0958-0115 16.4 µM 0.442041786464556 0.314295476276335 no 1061 0.329229484107566 1572 6833180
SGTC_2285 7945142 200 µM 0.440581658060896 0.314813674830267 no 1062 0.329757941951012 1575 2970608
SGTC_3306 9127676 59.7925 µM 0.439589142249801 0.315166126368346 no 1063 0.330117353028841 1548 41905287
SGTC_2231 micatex 6.853 µM 0.43863552621077 0.315504922807 no 1064 0.330462825420207 1594 20737 An antifungal of unknown mechanism.
SGTC_1705 st027868 56.3335 µM 0.438418891513047 0.315581909449041 no 1065 0.330541327170646 1659 292948
SGTC_1309 pyrazolanthrone 13.4 µM 0.435931575937216 0.31646641307944 no 1066 0.331443187345906 1667 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1112 tnp00069 1.16933 µM 0.43541643323299 0.316649732284318 no 1067 0.331630092164644 1660 145826
SGTC_2188 6126565 140.678 µM 0.434079987902719 0.317125530994494 no 1068 0.332115178571114 1619 874518
SGTC_3176 9106582 49.47 µM 0.433394995475007 0.317369517991445 no 1069 0.332363917813606 1555 17018027
SGTC_3025 9087895 49.47 µM 0.433262772679928 0.317416623484045 no 1070 0.332411939986839 1651 17173641
SGTC_603 3794-0023 45.9 µM 0.43261682624236 0.317646789882286 no 1071 0.332646581671416 1669 3802260
SGTC_2025 5147754 141 µM 0.431799746279244 0.317938036294106 no 1072 0.332943481975795 1650 315777 YLR208W SEC13
SGTC_2730 imipramine 71.33 µM 0.43137126020812 0.318090814280235 no 1073 0.333099221776214 1618 3696 A tricyclic antidepressant.
SGTC_260 nsc-65238 3.989 µM 0.428096516604546 0.319259454743412 no 1074 0.33429042638582 1649 3246252
SGTC_1143 3454-2408 5.08 µM 0.427513610050931 0.319467662375124 no 1075 0.33450263710878 1567 X1143
SGTC_1509 1326-1131 80 µM 0.426994270448827 0.31965321256914 no 1076 0.334691750445662 1670 768313
SGTC_382 3229-0966 23.2 µM 0.423334707107784 0.320961983025327 no 1077 0.336025537656906 1672 5722370
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.423155950969817 0.321025968814955 no 1078 0.336090741322016 1634 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_73 0327-0325 16.231 µM 0.422505532767473 0.321258830961186 no 1079 0.336328031572738 1732 53298
SGTC_1400 3771-8998 51.5 µM 0.420509052574259 0.321974047707737 no 1080 0.337056808828039 1648 670767
SGTC_385 1494-0393 12.4 µM 0.420250102733799 0.322066862001957 no 1081 0.33715137845407 1627 3090647
SGTC_104 0074-0074 590.992 µM 0.419244483893341 0.322427406900892 no 1082 0.337518732442606 1611 3943124
SGTC_1101 ebselen 5.29 µM 0.418143362682519 0.322822383944442 no 1083 0.337921151246346 1739 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1052 3253-3998 198 µM 0.416722750641192 0.323332259119299 no 1084 0.338440605782307 1569 5450317
SGTC_2232 chlorophetanol 41.5365 µM 0.416147202185197 0.323538925110017 no 1085 0.33865114581904 1692 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1082 camptothecin 424.86 nM 0.416021585139794 0.323584038493436 no 1086 0.338697104203969 1422 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_757 1066-0008 322 µM 0.415533607894322 0.323759312431352 no 1087 0.338875658856382 1663 6842497
SGTC_2385 9074692 200 µM 0.415148136042122 0.323897795646425 no 1088 0.339016731592407 1568 17046906
SGTC_3142 9086498 49.47 µM 0.414478251469938 0.324138513928851 no 1089 0.339261945733895 1669 25236367
SGTC_246 cycloheximide 667 µM 0.405939637837197 0.327213217866499 no 1090 0.342393476374404 1587 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2119 5528445 120.635 µM 0.405557922766889 0.327350947374238 no 1091 0.342533725437819 1683 791935
SGTC_2743 auranofin 4.32 µM 0.404617683285162 0.327690302537544 no 1092 0.342879279111725 1652 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1276 0871-0068 94.2 µM 0.404037220164969 0.327899876812146 no 1093 0.343092674638927 1697 3414906
SGTC_2431 5490079 200 µM 0.402818448603822 0.328340086559005 no 1094 0.343540894162131 1590 5722345
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.401287597150637 0.328893354673185 no 1095 0.344104197027856 1651 66535 A nucleotide analog.
SGTC_1414 3917-0015 5.4 µM 0.401003544579902 0.328996055983738 no 1096 0.344208757115624 1656 6618702
SGTC_1498 4478-3555 97.6 µM 0.400779771550162 0.329076971871819 no 1097 0.344291136620797 1686 3437919
SGTC_2395 5646831 180.19 µM 0.400439332268151 0.329200089407755 no 1098 0.344416479654189 1684 6808628
SGTC_1508 1080-0625 72.9 µM 0.400152603305414 0.329303797347309 no 1099 0.344522060864402 1628 767111
SGTC_1546 5-methoxyflavanone 78.7 µM 0.400135047854917 0.329310147462602 no 1100 0.344528525640622 1702 147795
SGTC_2399 5884133 200 µM 0.400046903159178 0.329342031693954 no 1101 0.344560985518702 1576 722445
SGTC_841 0251-0215 91.2 µM 0.399702459595005 0.329466637797367 no 1102 0.344687840155623 1669 3888614
SGTC_1387 3342-1166 1.8 µM 0.399032747777171 0.329708967332715 no 1103 0.344934537363818 1641 3418228
SGTC_420 mitomycin C 81.9 mM 0.398658758904901 0.329844323153423 no 1104 0.345072329809763 1604 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2838 9002687 71.43 µM 0.3984911409647 0.329904995463853 no 1105 0.345134093625959 1567 6457060
SGTC_233 rapamycin 362 pM 0.397523417132411 0.330255367865141 no 1106 0.34549076088021 1656 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2867 9039098 71.43 µM 0.396705563426674 0.330551594656006 no 1107 0.345792298553397 1614 6463460
SGTC_2619 obliquin 87.91 µM 0.396477199739149 0.33063432700551 no 1108 0.345876512334745 1716 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3217 9129673 49.47 µM 0.396261915418229 0.330712328497385 no 1109 0.345955909814725 1630 17248312
SGTC_933 2914-0560 114 µM 0.396108741094764 0.330767830864796 no 1110 0.346012405072455 1790 463887
SGTC_1216 1165-0504 9.65 µM 0.393849084114536 0.331587044180049 no 1111 0.346846231632054 1728 6304004
SGTC_1768 st044301 37.178 µM 0.393751581988134 0.331622410654994 no 1112 0.346882227217424 1580 3931349
SGTC_1093 fluphenazine 7.97 µM 0.39252200051991 0.332068539527494 no 1113 0.347336279461258 1659 6602611 An atypical antipsychotic.
SGTC_2456 5770359 74.46 µM 0.391785773983826 0.33233577852968 no 1114 0.347608253598199 1723 3118787
SGTC_268 camptothecin 39.6153 µM 0.391118019847986 0.332578236840414 no 1115 0.347855000766665 1644 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.390163529182599 0.332924929424012 no 1116 0.34820781412628 1703 5282309
SGTC_768 0384-0033 77.3 µM 0.389531024992525 0.333154747972374 no 1117 0.348441682358863 1605 3965305 YMR134W ERG29
SGTC_2748 diazoxide 86.69 µM 0.387924123861393 0.333738892478656 no 1118 0.349036092557945 1691 3019 A potassium channel activatior.
SGTC_132 0417-1715 25.805 µM 0.386728054250695 0.334173952394546 no 1119 0.349478772398954 1811 6769098
SGTC_2098 5376439 882.5 nM 0.385911358787338 0.334471146364049 no 1120 0.349781158977689 1769 2844116
SGTC_1234 0326-0494 15.5 µM 0.385700430010083 0.334547919823688 no 1121 0.349859272165381 1731 1547813
SGTC_810 3825-7150 143 µM 0.38522980701287 0.334719241233718 no 1122 0.350033580736023 1815 22330411 YGL099W LSG1
SGTC_2833 9001315 45.46 µM 0.384856653316154 0.334855105248347 no 1123 0.350171811253438 1650 2989378
SGTC_551 k048-0028 34.9 µM 0.383674237372168 0.335285761659726 no 1124 0.350609954754814 1729 6836383
SGTC_2429 5902844 64.44 µM 0.381849897110804 0.335950642742558 no 1125 0.351286352746849 1775 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2144 5628481 200 µM 0.381265040251965 0.336163902752872 no 1126 0.351503295939708 1671 2818399
SGTC_819 1013-0258 27.7 µM 0.381021568208517 0.336252697036761 no 1127 0.351593622222612 1638 5753198
SGTC_1341 1486-1360 280 µM 0.379034097968011 0.33697786896269 no 1128 0.352331271606484 1625 3976547
SGTC_1320 1313-0481 95.3 µM 0.37765992877961 0.33747961933994 no 1129 0.352841619567195 1781 6813365 YLR208W SEC13
SGTC_2402 5553605 200 µM 0.376379714901605 0.337947323977375 no 1130 0.353317312178152 1726 6758546
SGTC_283 0987-0079 11.7 µM 0.375584185696864 0.338238083347661 no 1131 0.353613024705262 1758 411556
SGTC_1201 1889-3372 45.9 µM 0.370797947985793 0.339989445277925 no 1132 0.355394014929367 1669 5392199
SGTC_468 gf-109203x 121 µM 0.370721250957325 0.340017538218032 no 1133 0.355422580240712 1763 2396 A protein kinase C inhibitor.
SGTC_485 niflumic acid 177 µM 0.370538118045597 0.340084620575227 no 1134 0.355490790191957 1708 4488 A COX2 inhibitor.
SGTC_3239 9133757 49.47 µM 0.370189421567719 0.340212363559891 no 1135 0.355620678986053 1728 17036923
SGTC_2705 st078069 42.8 µM 0.37017893444797 0.340216205741137 no 1136 0.35562458567859 1664 1530061
SGTC_2787 5284540 71.43 µM 0.369762424552866 0.340368816484719 no 1137 0.355779757422353 1658 736958
SGTC_394 menadione 8.33 µM 0.369726636377301 0.340381930622838 no 1138 0.355793091506904 1718 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_817 1391-0715 46 µM 0.369498409081963 0.340465566256739 no 1139 0.355878129386387 1631 1353946
SGTC_3193 9111931 49.47 µM 0.369062151406206 0.340625458042089 no 1140 0.356040699693194 1680 17087244
SGTC_1913 st060213 96.1 µM 0.366339774931224 0.341623876012032 no 1141 0.357055776623952 1809 688959
SGTC_2769 toremifene 3.73 µM 0.363719170081363 0.342586017689296 no 1142 0.358033863395647 1702 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1579 chlormadinone acetate 49.4 µM 0.363442463910202 0.342687668718184 no 1143 0.358137192816775 1796 45114258 A steroidal progestin.
SGTC_1805 st050013 60.3 µM 0.362111212722295 0.343176877489525 no 1144 0.358634462453321 1729 4037144
SGTC_2159 5658611 73.75 µM 0.362093027256395 0.343183562114805 no 1145 0.358641257033027 1777 793844
SGTC_2853 9015042 58.44 µM 0.361776190844715 0.34330003292043 no 1146 0.358759642825795 1595 6457456
SGTC_979 1426-2828 121 µM 0.360166038043886 0.343892163763345 no 1147 0.359361485252229 1768 747872
SGTC_2519 cryptotanshinone 88.04 µM 0.359975731645961 0.343962173947163 no 1148 0.359432641016597 1761 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1608 st001473 40.5 µM 0.359547510008298 0.344119728282289 no 1149 0.359592771363992 1625 7292267
SGTC_3004 9076122 71.4286 µM 0.359021857742214 0.344313166982529 no 1150 0.359789368888823 1772 44782551
SGTC_1449 4112-4002 201 µM 0.358624048788812 0.344459586750187 no 1151 0.359938176813559 1632 2059539
SGTC_1928 4'-methoxychalcone 40.3 µM 0.358347546714671 0.344561371369294 no 1152 0.360041620125586 1866 641818
SGTC_2982 9019404 25.97 µM 0.357725333357614 0.34479045872215 no 1153 0.360274436362177 1500 22333232
SGTC_2586 curcumin 80 µM 0.357498999111293 0.344873804892816 no 1154 0.360359137675483 1782 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_390 dec-rvkr-cmk 16.7 µM 0.35749020743028 0.344877042526279 no 1155 0.360362427934223 1726 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1986 st071812 45 µM 0.356161619906988 0.34536643996532 no 1156 0.360859766334664 1689 11838594
SGTC_2588 indole-3-carbinol 100 µM 0.354516101934719 0.34597294015905 no 1157 0.361476069507141 1827 3712 Induces cell cycle arrest.
SGTC_3206 9114350 49.47 µM 0.353844694472124 0.346220519217675 no 1158 0.361727638121437 1683 17087243
SGTC_1044 1222-0021 1.78 µM 0.353045345330879 0.346515362015988 no 1159 0.362027222939263 1743 4306703
SGTC_2551 apiole 73.87 µM 0.351848503697808 0.34695699519581 no 1160 0.362475940384093 1728 10659 A possible DNA adduct former.
SGTC_2371 9071574 200 µM 0.351746116180841 0.346994785736638 no 1161 0.362514336088669 1768 45596039
SGTC_1190 1486-1332 13 µM 0.351339251208209 0.347144971885662 no 1162 0.362666925648209 1640 4150046
SGTC_1119 parthenolide 318.541 nM 0.348467325780585 0.348205767987396 no 1163 0.363744624090365 1775 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2208 7283366 200 µM 0.34807960483083 0.348349070782817 no 1164 0.363890200359706 1792 898663
SGTC_587 k089-0003 57 µM 0.346997676949534 0.348749068933971 no 1165 0.36429653200013 1789 9659696
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.345507742502293 0.349300185876428 no 1166 0.364856345290859 1695 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_63 0099-0242 26.702 µM 0.34413429524873 0.349808496614214 no 1167 0.365372646189215 1803 3898502 YLR359W ADE13
SGTC_1129 3453-1384 223 µM 0.343496857891685 0.350044502771772 no 1168 0.365612352120383 1748 1084452
SGTC_3035 9091303 49.47 µM 0.341976700759854 0.35060756264841 no 1169 0.366184213212861 1723 25237002
SGTC_3076 9116187 49.47 µM 0.341690748991419 0.350713514723195 no 1170 0.366291817390307 1843 27241210
SGTC_2174 5790901 200 µM 0.340044054956388 0.351323880607036 no 1171 0.366911675759969 1706 786020
SGTC_2679 rapamycin 1 nM 0.33994337604612 0.351361210851363 no 1172 0.366949585192085 1747 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3333 9141820 12.094 µM 0.3393454913117 0.351582927160026 no 1173 0.367174738213567 1686 1939433
SGTC_3178 9107506 49.47 µM 0.339231344796837 0.351625262373163 no 1174 0.367217729007247 1755 8897194
SGTC_643 k048-0106 28.4 µM 0.338722706061706 0.351813931138059 no 1175 0.367409316915796 1788 6763920
SGTC_2461 5755302 26.15 µM 0.337492134111452 0.352270536622999 no 1176 0.367872970384097 1836 2788904
SGTC_2088 5278280 127.392 µM 0.337096517164381 0.352417376141322 no 1177 0.368022071419739 1739 791502
SGTC_2129 girgensonine 121.053 µM 0.336691787504661 0.352567620753046 no 1178 0.368174627453516 1774 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2844 9010103 25.97 µM 0.334454277621966 0.353398648511134 no 1179 0.369018393718128 1725 2480525
SGTC_2081 5214970 32.255 µM 0.334100262373503 0.353530196582632 no 1180 0.369151951045275 1821 2063512
SGTC_1684 st024538 14.6195 µM 0.331978330930564 0.35431904859963 no 1181 0.36995281070416 1707 6732859
SGTC_1092 toremifene 6.32 µM 0.331344509571662 0.354554800328332 no 1182 0.370192137257065 1758 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2 0422-0095 29 µM 0.331107645169016 0.354642917052739 no 1183 0.370281588521383 1717 6790840
SGTC_765 1319-0117 244 µM 0.330080883901237 0.35502497586171 no 1184 0.37066942347459 1672 3487746 YGL099W LSG1
SGTC_2299 7976368 114.88 µM 0.327991437761612 0.355802910631299 no 1185 0.37145906826495 1839 2979718
SGTC_1547 harmine 94.2 µM 0.327844365421335 0.355857690727746 no 1186 0.371514670364785 1729 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3067 9117431 49.47 µM 0.327765107721073 0.355887213110961 no 1187 0.371544635605471 1714 17150885
SGTC_2489 cantharidin 73.42 µM 0.326141144576412 0.356492306675478 no 1188 0.372158784268843 1672 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_42 0133-0086 60.653 µM 0.324578921313708 0.357074736889733 no 1189 0.372749891271396 1650 162923 Model of phenazepam hydroxylation.
SGTC_2883 9059145 45.46 µM 0.32427415057338 0.357188400822003 no 1190 0.37286524404133 1701 16476510
SGTC_1270 0831-1170 17.3 µM 0.321887647924181 0.358078881998655 no 1191 0.373768905562732 1736 6764716
SGTC_3058 9093861 49.47 µM 0.320104110533664 0.358744882177579 no 1192 0.374444704863722 1781 17217477
SGTC_2567 aureobasidin a 60 nM 0.318944918689505 0.359177972714816 no 1193 0.374884140743991 1784 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_963 1269-2853 151 µM 0.31741044645857 0.359751551689706 no 1194 0.375466090804393 1681 3668223
SGTC_2375 9072683 200 µM 0.31661970575256 0.360047250563348 no 1195 0.375766090743852 1910 16798029
SGTC_3039 9090270 49.47 µM 0.314939157894824 0.36067597238081 no 1196 0.376403924807445 1894 17173750
SGTC_2800 7887935 81.82 µM 0.314782790170261 0.360734491417944 no 1197 0.376463289710348 1788 2961002
SGTC_1605 st000082 49.1 µM 0.31432555440576 0.360905625976657 no 1198 0.37663689572517 1826 1114022
SGTC_2814 7977482 42.97 µM 0.311736343192767 0.361875242478864 no 1199 0.377620452717589 1865 6456762
SGTC_717 1532-0246 73.2 µM 0.310420179596709 0.362368464409363 no 1200 0.378120725230874 1754 9561992
SGTC_406 estrone 100 µM 0.3082976980278 0.363164328817125 no 1201 0.378927908752845 1883 5870 A steroid.
SGTC_2864 9034755 47.6 µM 0.307932989792403 0.363301142648031 no 1202 0.379066661230308 1908 4930451
SGTC_1491 4138-0063 26.5 µM 0.306668615099968 0.363775585350334 no 1203 0.379547810464197 1873 23883227
SGTC_1571 st070080 73.4 µM 0.306332289019209 0.363901823226493 no 1204 0.379675828526636 1846 4315245
SGTC_2296 7971656 126.45 µM 0.305329260084948 0.364278391495354 no 1205 0.380057696463084 1742 666570
SGTC_1507 4075-3230 155 µM 0.304826236524439 0.364467291555925 no 1206 0.380249249025813 1875 659771
SGTC_530 4358-1714 28 µM 0.304276522250536 0.364673762989307 no 1207 0.380458615111379 1823 1564641
SGTC_185 k048-0037 25.491 µM 0.303821385671959 0.364844740966874 no 1208 0.380631986512798 1903 6827589
SGTC_2235 salicylic acid 500 µM 0.303729267156877 0.364879349757671 no 1209 0.380667079373025 1820 338 A COX inhibitor and kinase inhibitor.
SGTC_2783 7738165 71.43 µM 0.303318461046982 0.365033702408579 no 1210 0.380823589300682 1665 17201110
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.302567628535885 0.365315870073346 no 1211 0.381109693708638 1801 4000243
SGTC_142 0335-0849 62.6745 µM 0.302516996176859 0.365334900664247 no 1212 0.381128989488647 1794 3889043 YPR107C YTH1
SGTC_1195 1502-0147 41.1 µM 0.302295348767021 0.365418212578662 no 1213 0.381213461866674 1753 817940
SGTC_59 0330-0160 1.33 µM 0.299963280830088 0.366295164882614 no 1214 0.382102582132176 1836 4293482
SGTC_2485 5633444 17.78 µM 0.299708011463632 0.366391199045437 no 1215 0.382199943557047 1710 5724239
SGTC_849 0386-0493 241 µM 0.29929656290768 0.366546006547345 no 1216 0.382356888434826 1783 726119
SGTC_3131 9127911 49.47 µM 0.298274915861842 0.366930495058256 no 1217 0.382746673831584 1806 45595681
SGTC_1311 1190-0148 100 µM 0.298252087771962 0.366939087749682 no 1218 0.382755384710533 1883 1961333
SGTC_1891 st059073 26.2 µM 0.296111384090871 0.36774516291486 no 1219 0.383572510197215 1934 688754
SGTC_3013 9080133 71.4286 µM 0.295417891306203 0.368006420592578 no 1220 0.383837333791804 1832 17050193
SGTC_3161 9100388 49.47 µM 0.294452224407291 0.368370315393763 no 1221 0.384206182677664 1833 25236368
SGTC_292 k038-0015 474 µM 0.293193539570782 0.368844806175568 no 1222 0.38468711095036 1830 46368540
SGTC_1634 st006576 41 µM 0.29286963674973 0.368966941325193 no 1223 0.384810899051585 1938 3915356
SGTC_1451 4152-0210 104 µM 0.292684265276865 0.369036845937676 no 1224 0.384881748987896 1914 659563
SGTC_1647 st011722 22.4 µM 0.292229890228466 0.369208211611695 no 1225 0.385055429737674 1829 2854783
SGTC_521 r062-0005 13.8 µM 0.291607631821153 0.369442935973014 no 1226 0.385293319794974 1754 2832033
SGTC_994 3910-0338 138 µM 0.291476914973175 0.369492250340659 no 1227 0.385343298476029 1870 3479481
SGTC_1878 temozolomide 1 mM 0.288700181224682 0.370540309720754 no 1228 0.386405412002697 1960 5394 DNA alkylating agent.
SGTC_2698 st077697 67.5 µM 0.287214356851137 0.371101519525348 no 1229 0.386974097025972 1716 3154499
SGTC_2462 5162487 171.77 µM 0.286927472407812 0.371209910094455 no 1230 0.387083927288578 1927 2259986
SGTC_2479 5617353 43.85 µM 0.285614151930974 0.371706238644738 no 1231 0.387586831559754 1862 2731746
SGTC_2627 acetyl isogambogic acid 100 µM 0.285518439446442 0.371742418545624 no 1232 0.387623489723656 1721 6857789 A caspase activator and apoptosis inducer.
SGTC_2803 7707263 71.43 µM 0.284879965577494 0.371983794517373 no 1233 0.387868052714643 1758 2199229
SGTC_1587 estradiol valerate 56.1 µM 0.284412743244609 0.372160460488332 no 1234 0.388047047185594 1945 13791 A steroid.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.283604883849642 0.372465991522447 no 1235 0.38835659698005 1973 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_556 4058-0063 51.5 µM 0.283113190642918 0.372651988360472 no 1236 0.388545035206863 1810 6615692
SGTC_644 1498-1197 63.3 µM 0.28248729544148 0.372888793851821 no 1237 0.388784943421286 1868 6741615
SGTC_2246 7293507 91.5585 µM 0.28101278303685 0.37344686076296 no 1238 0.389350297646557 1958 887656
SGTC_1377 2944-0135 198 µM 0.279768579816905 0.373917967889123 no 1239 0.38982752955802 1820 1894137
SGTC_3180 9109287 49.47 µM 0.278839820211371 0.374269757787569 no 1240 0.390183876906803 1816 18891271
SGTC_2233 sulbentine 40.3845 µM 0.278679270561681 0.374330580427743 no 1241 0.390245486110025 1855 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_539 4859-0462 2.54 µM 0.278165742080534 0.374525146587443 no 1242 0.390442565649951 1951 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_86 0417-1630 471.922 µM 0.27691132954339 0.375000553870026 no 1243 0.39092409646679 1932 3634867
SGTC_1650 st011916 45.8 µM 0.276349218806898 0.375213648770864 no 1244 0.391139928001363 1935 242528
SGTC_803 4488-1585 147 µM 0.274917647318206 0.375756526155011 no 1245 0.391689754381646 1909 747204
SGTC_2983 9022671 12.99 µM 0.274489572625433 0.375918907530837 no 1246 0.391854207925026 1983 6405161
SGTC_1957 st077035 62.4 µM 0.273886587696137 0.376147674796827 no 1247 0.392085889545743 1871 705593
SGTC_1597 7-benzyloxygramine 47.5 µM 0.273028617473665 0.376473256285396 no 1248 0.392415608718776 1787 260807
SGTC_952 1185-0122 232 µM 0.271951801943955 0.376882009295237 no 1249 0.392829539740502 1811 678600
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.271205246410764 0.37716547855514 no 1250 0.393116589047823 1776 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1550 gossypolone 36.6 µM 0.270971267456445 0.377254334663652 no 1251 0.393206565519979 1881 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2840 9008771 71.43 µM 0.270787995008199 0.377323938952202 no 1252 0.393277046818971 1984 2992978
SGTC_2078 5212016 200 µM 0.269826272573665 0.377689252834715 no 1253 0.393646954823098 1958 1899708
SGTC_217 ketoconazole 989 nM 0.269148706397494 0.377946694623932 no 1254 0.393907625261292 1863 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2767 sibutramine 71.45 µM 0.267914514996419 0.378415765834803 no 1255 0.39438256032827 1944 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2518 prenyletin 46.28 µM 0.266976414563056 0.378772423576604 no 1256 0.394743660321496 1947 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2674 ligustilide 100 µM 0.266869828992454 0.378812953035047 no 1257 0.394784693691256 1848 5319022 A signalling regulator.
SGTC_2223 6903751 107.57 µM 0.266165409631314 0.379080843936713 no 1258 0.39505591075924 1897 5598863
SGTC_541 4513-1321 94 µM 0.263324486281096 0.380161836275206 no 1259 0.396150244074127 1792 747515
SGTC_2434 5670830 169.91 µM 0.262128895787669 0.380617047870276 no 1260 0.396611034915335 1831 1549830
SGTC_2143 5623677 140.463 µM 0.261678155097895 0.380788706762519 no 1261 0.396784791770438 1937 5375313
SGTC_113 0099-0221 2.5 µM 0.260952952417424 0.381064940276532 no 1262 0.397064394483062 1941 89219
SGTC_986 1493-0483 84 µM 0.259754833856703 0.381521442681716 no 1263 0.397526446315182 1967 40079
SGTC_1722 st034304 3.6505 µM 0.259012347554864 0.381804424663647 no 1264 0.397812856771414 1815 4036148 YLR033W RSC58
SGTC_1911 st060208 74.3 µM 0.258465487277148 0.382012888587221 no 1265 0.398023840682012 1926 688783
SGTC_1335 1486-0900 202 µM 0.257907988000782 0.382225443330633 no 1266 0.39823895991884 1838 X1335
SGTC_542 3381-0244 89.3 µM 0.254227055059239 0.383629740904919 no 1267 0.399660075080108 1968 1112843
SGTC_1223 0764-0573 147 µM 0.253819492548535 0.383785322808404 no 1268 0.399817506804747 1856 1609797
SGTC_1191 1487-1166 10.6 µM 0.252215186308443 0.384397928501404 no 1269 0.400437370230263 1929 3955771
SGTC_1009 4106-0057 9.87 µM 0.251675457853205 0.384604089277188 no 1270 0.40064596414812 2000 2928005
SGTC_501 nsc-95397 161 µM 0.247573878066363 0.386171837542553 no 1271 0.402232061947444 1952 262093
SGTC_791 1348-1292 225 µM 0.244605072388078 0.38730776744498 no 1272 0.403381118079113 1951 5437054
SGTC_251 melphalan 456.522 µM 0.242541875523497 0.388097760959687 no 1273 0.404180156648139 1944 460612 A DNA alkylator.
SGTC_2785 7756463 72.73 µM 0.242183371275673 0.388235078778613 no 1274 0.404319039689517 1833 2201551
SGTC_703 3875-0075 71.8 µM 0.239294332818404 0.389342175289674 no 1275 0.405438679767538 1893 2850814
SGTC_320 4092-0846 5.34 µM 0.236803572628181 0.390297371122134 no 1276 0.406404589911435 1955 1359356
SGTC_926 2268-1401 59.4 µM 0.235156758174844 0.39092928165642 no 1277 0.407043533460167 2008 2931578
SGTC_1207 2099-0101 141 µM 0.234240128422359 0.391281132898214 no 1278 0.407399281734167 2005 5837381
SGTC_554 4483-2211 187 µM 0.231809645981946 0.392214511380832 no 1279 0.408342932349514 1899 747107
SGTC_2264 7948757 110.76 µM 0.231516998506939 0.392326938787254 no 1280 0.408456590611414 1825 2971411
SGTC_3296 9122258 64.045 µM 0.231454667397931 0.392350885909257 no 1281 0.408480799727606 1898 4730474
SGTC_1798 st045719 60.953 µM 0.230790953827709 0.39260590470817 no 1282 0.408738604669263 1981 3980186
SGTC_2424 5537928 59.2 µM 0.228959604295424 0.393309803370818 no 1283 0.409450156623705 1853 5382802
SGTC_150 3970-0969 77.2 µM 0.22895519737133 0.393311497640654 no 1284 0.409451869249393 1921 6615640
SGTC_245 methotrexate 289.6 µM 0.228493447675018 0.393489031422334 no 1285 0.409631324703735 1953 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2863 9028737 58.44 µM 0.227642772635472 0.393816157395237 no 1286 0.409961982537301 2053 6460917
SGTC_3162 9099653 49.47 µM 0.227541759112997 0.393855006995535 no 1287 0.410001250804426 1999 25237511
SGTC_3153 9100258 49.47 µM 0.227091443357556 0.394028210388417 no 1288 0.410176318731907 1847 25236848
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.226484132902381 0.394261831302307 no 1289 0.410412449374078 1795 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2940 9060638 45.86 µM 0.225630760000217 0.394590172086725 no 1290 0.410744307342328 1899 4027022
SGTC_401 neomycin 50 µM 0.225569401922076 0.394613782896021 no 1291 0.41076817061584 1931 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_959 1222-0044 107 µM 0.225567737566108 0.394614423351581 no 1292 0.410768817918775 2055 6083612
SGTC_1014 4130-3005 69.3 µM 0.224934566486436 0.394858092564799 no 1293 0.411015089043945 1853 743608
SGTC_2726 cimetidine 79.27 µM 0.224664818561988 0.394961914709162 no 1294 0.41112001783323 2017 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2710 st078562 53.7235 µM 0.224123926230273 0.395170118949918 no 1295 0.411330437779896 1942 17250908
SGTC_2583 asiatic acid 100 µM 0.221191273345935 0.396299496851242 no 1296 0.412471751925162 1940 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.220673904224616 0.396498828672549 no 1297 0.412673175985642 2026 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3345 9148410 3.559 µM 0.219982882272147 0.39676510759721 no 1298 0.412942243071905 2012 4903596
SGTC_653 0203-0016 55.2 µM 0.217851914848105 0.397586558858087 no 1299 0.413772246821396 1952 295302
SGTC_314 1671-0008 2.74 µM 0.216961065956584 0.39793010065626 no 1300 0.414119343537923 1944 3913060
SGTC_1418 3966-3099 2.4 µM 0.216096498031764 0.398263583306647 no 1301 0.414456264696999 1989 740335
SGTC_968 1309-0633 340 µM 0.209555599962809 0.400788941603517 no 1302 0.417007268109295 2055 3761976
SGTC_1554 st069299 38.7 µM 0.209080821828607 0.400972410342353 no 1303 0.417192572904336 1987 24207999
SGTC_1905 st060207 84.5 µM 0.208027625436324 0.401379475435124 no 1304 0.417603698598363 1917 1948547
SGTC_2298 7976326 193.81 µM 0.207855048215988 0.401446187518968 no 1305 0.417671074435639 2006 2235818
SGTC_2951 9072950 58.06 µM 0.207363898860729 0.401636063732493 no 1306 0.417862837175468 2054 16488155
SGTC_1931 st074438 57.1 µM 0.206853924674746 0.401833242120971 no 1307 0.418061970488363 2049 2787313
SGTC_444 curcumin 90.4 µM 0.205827926682731 0.402230013614914 no 1308 0.418462662950058 2001 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1351 1496-0003 46.5 µM 0.20564635234625 0.402300242114229 no 1309 0.418533583676015 2021 3891978
SGTC_824 1304-0008 100 µM 0.205380845896225 0.402402939172933 no 1310 0.418637292030766 1937 768245
SGTC_1379 2144-0755 36.5 µM 0.20348737164943 0.403135523969001 no 1311 0.419377057585179 2060 5392327
SGTC_256 clotrimazole 625 nM 0.202536453720944 0.403503562378429 no 1312 0.419748681466442 2018 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1816 st051957 91.6 µM 0.199716546319814 0.404595466272553 no 1313 0.42085113619206 1972 674121
SGTC_2598 perillyl alcohol 100 µM 0.198957257164705 0.404889600048547 no 1314 0.421148089975951 1996 10819 An apoptosis inducer.
SGTC_58 0957-0393 9 µM 0.19819044860527 0.405186701240089 no 1315 0.421448030088348 1927 6997992
SGTC_449 xestospongin c 11.1929 µM 0.196339120090313 0.405904226336313 no 1316 0.422172371908692 2013 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1397 3532-0190 20.1 µM 0.195353092562976 0.406286513278522 no 1317 0.422558267888799 1970 5322280
SGTC_3100 9120536 49.47 µM 0.194481000380901 0.40662470149343 no 1318 0.422899635604182 2077 16421196
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.192650600631824 0.407334737582728 no 1319 0.423616306789094 2049 6728940
SGTC_1914 st062367 72.6 µM 0.191598597798728 0.407742961278886 no 1320 0.424028320479495 1928 978205
SGTC_2861 9024595 19.48 µM 0.190706208383324 0.408089326459303 no 1321 0.424377887189409 2098 16482810
SGTC_1845 st056753 3.01 µM 0.189714666575352 0.40847426012793 no 1322 0.424766363633697 1885 5375839
SGTC_3174 9107204 49.47 µM 0.189329044007925 0.408623989349337 no 1323 0.424917466566763 2044 3938802
SGTC_2303 7774051 200 µM 0.189201119724929 0.408673662634829 no 1324 0.424967595050306 2051 2953184
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.188234575661373 0.409049021223486 no 1325 0.425346384725641 1943 6857784
SGTC_2259 7964009 200 µM 0.185849159003807 0.409975757052322 no 1326 0.426281526356979 2041 313134
SGTC_1773 st048542 73.5835 µM 0.185224533422521 0.41021850779578 no 1327 0.426526463566671 1903 3237138
SGTC_3029 9088683 49.47 µM 0.184634681628862 0.41044777585187 no 1328 0.426757790795022 1998 25236615
SGTC_315 k915-0449 187 µM 0.184382226401865 0.410545911416525 no 1329 0.426856806026697 2017 20970215 YNL149C PGA2
SGTC_1827 berberine 7.24 µM 0.183824249477951 0.410762830650665 no 1330 0.427075665983734 1847 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1637 st007924 17.4 µM 0.183407005815282 0.410925056231344 no 1331 0.427239339630179 1985 683336
SGTC_1292 0kpi-0043 232 µM 0.183300213009731 0.410966580042698 no 1332 0.427281233635844 1971 3333905
SGTC_1077 5-fluorocytosine 377 nM 0.182556353744655 0.411255839461409 no 1333 0.427573066694889 1983 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2910 7948405 25.97 µM 0.182453741316715 0.411295745438767 no 1334 0.427613327019201 2077 2971328
SGTC_2792 7535235 81.82 µM 0.180392912348817 0.412097395686873 no 1335 0.428422059089836 1911 1281891
SGTC_664 1222-0054 14.9 µM 0.178602746327156 0.412794057606706 no 1336 0.429124818954041 2014 6813991
SGTC_205 1486-1330 71.903 µM 0.177680365983384 0.413153119010093 no 1337 0.429487002778137 2003 4118834
SGTC_2069 5228469 200 µM 0.17741506532996 0.413256407905879 no 1338 0.429591187301739 1987 2835210
SGTC_1500 4488-1866 171 µM 0.176962480918269 0.413432625412408 no 1339 0.429768930147463 2088 2900003
SGTC_1681 tripelennamine 100 µM 0.176881931690878 0.413463989753339 no 1340 0.429800565626683 2117 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2173 5763948 167 µM 0.176213713123956 0.413724202658581 no 1341 0.430063023922933 2102 2867177
SGTC_1126 isoteolin 1.0172 µM 0.176160338290829 0.413744989140793 no 1342 0.430083989457488 1964 133323
SGTC_1149 3909-7961 23.3 µM 0.175064537746601 0.414171794884549 no 1343 0.430514461345034 1928 735261
SGTC_1976 st070609 63.5 µM 0.174458309292187 0.41440795971831 no 1344 0.430752646319842 2090 682556
SGTC_1333 1482-0047 286 µM 0.174266450047291 0.414482707640602 no 1345 0.43082803237773 2125 3811116
SGTC_1645 Cervolide 78 µM 0.173004984672716 0.414974248664169 no 1346 0.431323754752238 2001 23173 A fragrance.
SGTC_2003 4023581 200 µM 0.168413853150593 0.41676434178608 no 1347 0.433128855261326 1973 16641307
SGTC_807 1315-0151 48 µM 0.166628682946974 0.417460852352614 no 1348 0.433831111740288 2139 4011080
SGTC_2381 9035592 200 µM 0.166065527034284 0.417680629819375 no 1349 0.43405269142962 1936 4749657
SGTC_2446 5162541 200 µM 0.165943135618793 0.417728397749411 no 1350 0.434100850378728 1980 1549321
SGTC_487 nimodipine 119 µM 0.165924502361643 0.417735670197025 no 1351 0.434108182335643 2124 4497 L-type voltage-gated calcium channels inhibitor
SGTC_724 3910-0327 137 µM 0.165902922050918 0.417744092896993 no 1352 0.434116673950127 1983 2885483
SGTC_3283 9109332 35.8195 µM 0.165249864844681 0.417998996071742 no 1353 0.434373659127896 2086 17027281
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.164656943048568 0.418230456861217 no 1354 0.434607004386114 2101 88881 An O-methylated flavonoid and antioxidant.
SGTC_3275 9138069 49.47 µM 0.164401819370005 0.418330059031819 no 1355 0.434707415705829 2026 17617007
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.163839412404264 0.418549645359067 no 1356 0.434928782137841 2044 676296 Flavone; oxidizing agent.
SGTC_3129 9127257 49.47 µM 0.163144350483185 0.418821060587058 no 1357 0.435202390455539 1873 837894
SGTC_2692 st077426 47.7 µM 0.163102066642988 0.418837573282418 no 1358 0.435219036320931 2098 25238571
SGTC_730 1436-0052 41.2 µM 0.161010188244044 0.419654672090021 no 1359 0.436042688140733 2151 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2194 5927483 104.545 µM 0.160775087256148 0.419746525510154 no 1360 0.436135273720334 2102 760979
SGTC_2362 9071156 126 µM 0.160425198157566 0.41988323447793 no 1361 0.436273070708528 2096 653133
SGTC_2265 7929201 200 µM 0.160313998791021 0.419926684414933 no 1362 0.436316866027877 2119 1265108
SGTC_2216 7189485 200 µM 0.158848874817753 0.420499256547498 no 1363 0.436893970553334 2115 731273
SGTC_492 tmb-8 126 µM 0.157988110469725 0.420835722784998 no 1364 0.437233083761353 2125 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2875 9039966 71.43 µM 0.156767960548296 0.421312769154599 no 1365 0.437713862181919 2094 6463691
SGTC_3026 9090633 49.47 µM 0.15636688909618 0.421469602755347 no 1366 0.43787191738795 2041 25236842
SGTC_270 tamoxifen 5.46 µM 0.154373731617484 0.42224918453175 no 1367 0.438657532247359 2151 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_423 5-fluorouracil 457 µM 0.154310442205646 0.422273943866206 no 1368 0.438682482121366 1878 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1511 0906-3109 28.5 µM 0.153145140628297 0.422729874147007 no 1369 0.439141909319362 2139 2882180
SGTC_2666 tannic acid 100 µM 0.152456224094067 0.422999465046002 no 1370 0.43941355743777 2094 16134267 A thiamine antagonist.
SGTC_1422 4031-0024 15.5 µM 0.151864366540717 0.423231103053718 no 1371 0.439646956817286 2140 782427
SGTC_738 1315-0003 72.4 µM 0.151025808828953 0.423559338653876 no 1372 0.439977678451452 2131 6251474
SGTC_3137 9097352 49.47 µM 0.150917534031248 0.423601724394997 no 1373 0.440020384376148 2101 44120435
SGTC_1504 k297-0033 30 µM 0.150373129398963 0.423814852876891 no 1374 0.440235119916571 1969 4388117
SGTC_592 k241-0073 46.5 µM 0.149909074453046 0.423996542930458 no 1375 0.440418176123235 2144 4230158
SGTC_1727 st034309 9.9045 µM 0.149606278036561 0.424115104624097 no 1376 0.440537627388861 2156 870305
SGTC_996 3970-0799 1.8 µM 0.149566625808442 0.424130631192898 no 1377 0.440553270342276 2121 6615648 YGL040C HEM2
SGTC_2112 5488546 200 µM 0.149102397181401 0.424312417315714 no 1378 0.440736417179706 2076 600757
SGTC_2244 6635614 200 µM 0.148199575352591 0.424665997125911 no 1379 0.44109263346858 2003 836499
SGTC_1512 0259-0544 12.2 µM 0.147874234126393 0.424793428158841 no 1380 0.441221011407112 2029 18476
SGTC_1502 4534-4282 27.7 µM 0.146958344906054 0.425152209704629 no 1381 0.441582449606257 2045 3278949
SGTC_2888 9058547 12.99 µM 0.145999839152529 0.425527751828127 no 1382 0.44196075770219 2042 16476514
SGTC_2605 digitonin 300 nM 0.145774452177413 0.42561606816883 no 1383 0.442049722321013 2176 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1629 st005085 44.9 µM 0.145684915812974 0.425651153415267 no 1384 0.442085064875428 2008 24207091
SGTC_1010 4112-3296 15.2 µM 0.145252131695784 0.425820750206255 no 1385 0.442255903593541 2172 704384
SGTC_2062 5245942 200 µM 0.144707523311181 0.426034187502991 no 1386 0.44247089947147 2161 1376160
SGTC_102 gallobenzophenone 83.616 µM 0.144699894537564 0.426037177447247 no 1387 0.442473911214484 2151 70837
SGTC_1187 1391-0724 117 µM 0.143010494657088 0.4266994081481 no 1388 0.44314094642665 2044 6997986
SGTC_834 0312-0008 75.7 µM 0.142665993725787 0.426834475078635 no 1389 0.44327698750322 2126 6385573 YIL048W NEO1
SGTC_1633 st005664 67.9 µM 0.142538523440192 0.426884453955507 no 1390 0.443327326348314 2080 2063822
SGTC_190 3970-0790 3.722 µM 0.142445303702439 0.42692100453278 no 1391 0.443364140008296 2159 2832352
SGTC_998 3996-0085 177 µM 0.142087286053916 0.427061385695527 no 1392 0.443505530272041 2119 715391
SGTC_92 0063-0024 660.874 µM 0.141607857492511 0.427249387370496 no 1393 0.443694880051236 2182 3594437
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.14150466012051 0.427289857040357 no 1394 0.443735639421842 2055 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1856 st057054 55.7 µM 0.140311746255666 0.427757723135099 no 1395 0.444206841982587 2164 1266018
SGTC_1750 st081859 2.357 µM 0.140119178400863 0.427833258640888 no 1396 0.44428291395225 2065 5291695
SGTC_2107 5363541 170.161 µM 0.139765797528814 0.427971880569638 no 1397 0.444422518804037 2167 244052
SGTC_2268 7933382 153.85 µM 0.139508948366274 0.428072641253137 no 1398 0.444523992657358 2168 935025 YOR257W CDC31
SGTC_1703 st026983 48.3 µM 0.139181477093104 0.428201113449826 no 1399 0.44465337258534 2166 1104023
SGTC_2497 7-hydroxyflavone 100 µM 0.138833298585403 0.428337717771806 no 1400 0.444790940158331 2157 5281894
SGTC_2561 acetosyringone 100 µM 0.137943285652746 0.428686944353396 no 1401 0.445142620192516 2197 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1720 st037298 9.481 µM 0.137503792432451 0.428859414949653 no 1402 0.445316297646001 2049 597396
SGTC_278 4092-0821 23.9 µM 0.137107533459736 0.42901493075051 no 1403 0.445472898933774 2100 877900
SGTC_1992 st073643 23.3 µM 0.136782258205395 0.429142596517322 no 1404 0.445601453862067 2158 3161292
SGTC_1157 4092-0394 27.6 µM 0.136563353490735 0.429228517580984 no 1405 0.445687972363388 2139 3659885
SGTC_2820 7989630 71.43 µM 0.135454081852971 0.429663963044391 no 1406 0.446126433477069 2180 2984098
SGTC_1997 st073024 93.8 µM 0.13543919585875 0.429669807136387 no 1407 0.44613231790399 2175 686268
SGTC_1202 1988-0068 29.6 µM 0.13524581882163 0.429745726421237 no 1408 0.446208760838742 1998 2850480
SGTC_1106 tegaserod maleate 11.7 µM 0.133688730862928 0.430357129252664 no 1409 0.446824358317431 2077 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_133 0724-0033 378.92 µM 0.133096002523449 0.430589912661543 no 1410 0.447058728272751 2178 280309
SGTC_2819 7996655 46.38 µM 0.132439998410122 0.430847574612076 no 1411 0.447318139573905 2143 6456960
SGTC_563 tetrahydrosecaminediol 614 µM 0.131150860248611 0.431354001393466 no 1412 0.447827983964861 2167 334274 A psychoactive constituent of the cannabis plant.
SGTC_1540 guanosine 70.6 µM 0.130060886193325 0.431782276370926 no 1413 0.448259127750365 2157 6802 Guanosine is a purine nucleoside
SGTC_2727 riluzole 51.77 µM 0.129054687509426 0.432177705344877 no 1414 0.448657188107674 2206 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2952 9073731 13.78 µM 0.126958837475081 0.433001577333751 no 1415 0.449486488890594 2074 16457353
SGTC_2421 5690543 90.72 µM 0.126156056819808 0.433317225210711 no 1416 0.449804197476694 2084 3397993
SGTC_13 0199-0087 65 µM 0.126019183875926 0.43337104696896 no 1417 0.449858369548787 2192 4589825
SGTC_2284 7945075 39.21 µM 0.125529066255209 0.433563783221827 no 1418 0.450052357741762 2190 1245402
SGTC_452 diindolylmethane 8 µM 0.12527336415319 0.433664343042934 no 1419 0.45015356918588 2131 3071 Inhibits expression of several cancer promoting factors.
SGTC_2237 6667747 47.222 µM 0.124280289704765 0.434054929534498 no 1420 0.450546676419034 2025 729940 YDL015C TSC13
SGTC_1038 k292-0204 154 µM 0.122083158738865 0.434919312256973 no 1421 0.451416579741581 2171 4454212
SGTC_2591 skatole 100 µM 0.121750879223383 0.435050062953598 no 1422 0.451548158567848 2097 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_24 0417-1663 219 µM 0.121298175434514 0.435228211560583 no 1423 0.451727432570569 2080 4329390
SGTC_3121 9125696 49.47 µM 0.120860464754969 0.435400472561316 no 1424 0.451900778553932 2216 1235365
SGTC_3135 9127742 49.47 µM 0.120829479891414 0.435412667116739 no 1425 0.451913049796543 2040 3643468
SGTC_1839 st053978 48 µM 0.119700093255684 0.435857195908916 no 1426 0.452360363241972 2202 3788398
SGTC_3291 9121177 71.43 µM 0.118707581169969 0.43624791753965 no 1427 0.452753515058338 2096 17015612
SGTC_2602 kawain 100 µM 0.118559709860238 0.436306135283119 no 1428 0.452812093507174 2227 5369129
SGTC_3299 9121982 43.1275 µM 0.118250083313554 0.436428041416277 no 1429 0.452934753775313 2077 17594604 YPL160W CDC60
SGTC_605 1315-0399 119 µM 0.117093520504977 0.436883456523536 no 1430 0.453392972151662 2144 24020461
SGTC_226 1,3-diallylurea 8.28947 mM 0.116867620944257 0.436972417873981 no 1431 0.453482478514564 2144 74537 YKL182W FAS1
SGTC_1581 himbacine 57.9 µM 0.116026912271361 0.437303524745146 no 1432 0.453815606464147 2049 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2630 antimycin a 100 µM 0.11572102958323 0.437424005279631 no 1433 0.453936819512886 2175 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_582 0987-0078 156 µM 0.112852788607034 0.438554023797808 no 1434 0.455073633181265 2211 1625765
SGTC_1499 4480-0877 67.3 µM 0.112188738848447 0.438815715333982 no 1435 0.455336878948451 2210 2861909
SGTC_681 1642-0006 26.6 µM 0.112129915117878 0.438838898129754 no 1436 0.455360199079101 2211 4446530
SGTC_2234 tolnaftate 200 µM 0.1115015794796 0.43908654216305 no 1437 0.45560930658389 2212 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_814 3342-0569 96 µM 0.111031269102898 0.439271919784448 no 1438 0.455795775434042 2209 4346283
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.110928785744283 0.439312316411985 no 1439 0.455836409371424 2188 6708784 An antioxidant flavonoid
SGTC_589 1227-0070 34.1 µM 0.110642665429634 0.439425101928091 no 1440 0.455949856525754 2132 2841384
SGTC_2202 7226349 200 µM 0.109808518607409 0.439753941564761 no 1441 0.456280617515863 2197 844334
SGTC_3078 9116413 49.47 µM 0.109805663610425 0.439755067140975 no 1442 0.456281749648853 2186 17177322
SGTC_2892 9047358 58.44 µM 0.109630797116118 0.439824008795585 no 1443 0.456351092649491 2119 6466771
SGTC_373 0844-0104 25.9 µM 0.106422287596868 0.441089295363471 no 1444 0.45762365527277 2243 5375804
SGTC_712 r015-0009 80.6 µM 0.1063683986442 0.441110551826716 no 1445 0.457645032516503 2167 6813872 YLR060W FRS1
SGTC_3264 9137442 49.47 µM 0.105986495041523 0.441261198318756 no 1446 0.457796533613136 2223 17015726
SGTC_2582 agaric acid 100 µM 0.105945961717667 0.441277187677531 no 1447 0.457812613536422 2165 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2141 5621638 7.665 µM 0.105386077797983 0.441498057333753 no 1448 0.458034731426205 2200 2856238
SGTC_520 3584-0023 682 µM 0.104562374129656 0.44182303479084 no 1449 0.458361536041047 2040 1340790
SGTC_1241 0364-0022 50.8 µM 0.102454932499966 0.442654665728303 no 1450 0.459197791597652 2169 4563895
SGTC_700 3453-2283 142 µM 0.102082522695824 0.442801651109876 no 1451 0.459345586702332 2196 565664
SGTC_2709 st078560 56 µM 0.0999718741586023 0.443634845227163 no 1452 0.460183327363063 2238 17250903
SGTC_2384 9036245 200 µM 0.0997814600444269 0.443710024918278 no 1453 0.460258913662295 2182 6462766
SGTC_41 0478-0632 82.643 µM 0.0981109949142067 0.444369647937133 no 1454 0.460922078485507 2252 3750424
SGTC_1355 1499-0035 1.68 µM 0.0976862068714945 0.444537410282385 no 1455 0.461090734245222 2176 1548538
SGTC_1043 0916-0009 19.3 µM 0.0976440479808297 0.44455406071532 no 1456 0.461107473186526 2265 3101130
SGTC_2026 5148700 152 µM 0.0966180828542932 0.444959290359068 no 1457 0.461514847819759 2175 79838
SGTC_3092 9117248 49.47 µM 0.0957900376496016 0.445286388732234 no 1458 0.461843664889077 2264 17141857
SGTC_2059 5238311 157 µM 0.0952966242098158 0.445481316993607 no 1459 0.462039611971581 2168 703021
SGTC_939 1165-0479 45.3 µM 0.0951594992727688 0.445535492010456 no 1460 0.46209406942544 2251 1377347
SGTC_1156 4092-0367 4.88 µM 0.094841753711884 0.445661030130909 no 1461 0.462220260830567 2096 1357585
SGTC_2291 7917025 104.35 µM 0.094829521406585 0.445665863102431 no 1462 0.462225118918811 2165 2964612
SGTC_3172 9105863 49.47 µM 0.094383777875598 0.445841981425186 no 1463 0.462402150827871 2238 2348785
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0924755338312027 0.446596070662172 no 1464 0.463160114543396 2185 688664
SGTC_2849 9019321 12.99 µM 0.0920795917625198 0.446752561127419 no 1465 0.463317401485726 2182 16489627
SGTC_3322 9139058 2.11 µM 0.092064257895306 0.446758621787053 no 1466 0.463323492939527 2199 4908926 YPR165W RHO1
SGTC_3356 9151811 4.48 µM 0.0918025350939206 0.446862068763617 no 1467 0.463427464928178 2171 1859254 YPR165W RHO1
SGTC_2333 9017922 200 µM 0.0914081162689759 0.44701797119857 no 1468 0.463584156450206 2225 3163164
SGTC_864 0469-0573 172 µM 0.0908666781517352 0.447231999467754 no 1469 0.463799263803628 2072 689425
SGTC_886 0866-0150 153 µM 0.0905985120789575 0.447338010112053 no 1470 0.463905807130238 2236 271463
SGTC_600 1495-0418 41.6 µM 0.0897409086535896 0.447677060662477 no 1471 0.464246553334962 2183 5377768
SGTC_2995 9067767 71.4286 µM 0.0890299871008729 0.447958150036676 no 1472 0.464529039240303 2163 11673567
SGTC_1208 2323-2347 50.3 µM 0.0885225687677703 0.448158792808155 no 1473 0.464730673733821 2262 5412760
SGTC_1023 4482-3888 16 µM 0.0870658329507956 0.448734887122639 no 1474 0.46530959178827 2250 3303168
SGTC_3231 9132313 49.47 µM 0.0862729197048559 0.449048505495591 no 1475 0.465624732570351 2159 4905967
SGTC_883 0850-0245 24.6 µM 0.0840948866675342 0.449910139007128 no 1476 0.466490495046448 2201 6823229 YPR165W RHO1
SGTC_358 0075-0058 9.45 µM 0.083350250489151 0.450204772707649 no 1477 0.466786522576681 2304 1069125
SGTC_2972 9093619 59.92 µM 0.0823019160836323 0.450619618599951 no 1478 0.467203315388636 2102 25236256
SGTC_2735 sertaconazole 140 nM 0.0818948148725449 0.450780730872181 no 1479 0.467365178861457 2280 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1728 st035614 33.7865 µM 0.0811977610037824 0.451056612127309 no 1480 0.467642340049302 2128 15945546
SGTC_2765 myclobutanil 7.74 µM 0.081091831177627 0.451098539300569 no 1481 0.46768446103482 2172 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2957 9076800 11.52 µM 0.0808526749032872 0.451193199693904 no 1482 0.467779558319542 2181 16459615
SGTC_2028 5153890 36.43 µM 0.0808095824992596 0.45121025638432 no 1483 0.467796693631687 2229 2830968 YPR165W RHO1
SGTC_383 2324-0395 7.37 µM 0.0808042439383054 0.451212369481832 no 1484 0.467798816467241 2221 3146421
SGTC_2157 5649910 96.377 µM 0.076404240051184 0.452954434003757 no 1485 0.46954874819776 2226 2858091
SGTC_1337 1486-1011 40.3 µM 0.0727917506413548 0.454385381824624 no 1486 0.470985917788733 2294 X1337
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0724853652787082 0.454506772028476 no 1487 0.471107825823555 2285 688801
SGTC_965 1291-5240 308 µM 0.0723616962659571 0.454555771026077 no 1488 0.471157033401113 2257 2834598
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0714445194405472 0.454919187916349 no 1489 0.471521989360636 2250 364106
SGTC_2180 6301957 200 µM 0.0684913992527736 0.456089570170073 no 1490 0.472697233200902 2281 845462
SGTC_10 0279-0212 42.575 µM 0.0672556507008083 0.45657943642087 no 1491 0.47318909125954 2285 39851 YBR002C RER2
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0665702546200201 0.456851164539241 no 1492 0.473461913286576 2246 7104
SGTC_748 act1.228 77.9 µM 0.064869376282275 0.457525571702935 no 1493 0.474139001703587 2252 4421505 YNR035C ARC35
SGTC_1812 st052057 4.327 µM 0.06457891490383 0.457640753441833 no 1494 0.474254636564374 2278 3645418
SGTC_3073 9114972 49.47 µM 0.0643786727743725 0.457720161033808 no 1495 0.474334355726836 2306 41905075
SGTC_2477 5967686 25.23 µM 0.063625403919201 0.458018890815507 no 1496 0.474634251659168 2270 776118
SGTC_2575 plumbagin 510 nM 0.0635957657564726 0.458030645141902 no 1497 0.474646051677981 2265 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_478 N-arachidonylglycine 10 µM 0.0635128953309573 0.458063511275045 no 1498 0.47467904549364 2295 5283389
SGTC_448 monastrol 171 µM 0.0632978692489577 0.458148791235521 no 1499 0.474764656227943 2250 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1817 st052116 64.4 µM 0.0624072960477438 0.458502015590135 no 1500 0.475119242440793 2271 4361398
SGTC_115 0527-0192 112.043 µM 0.0622956034885678 0.458546318065024 no 1501 0.4751637147933 2153 4233931
SGTC_3287 9117173 37.0625 µM 0.062116194415226 0.458617481143256 no 1502 0.475235150311749 2309 2789709
SGTC_2521 angolensin 13.4 µM 0.0621100165168871 0.458619931646427 no 1503 0.475237610186875 2232 821428 A flavenoid.
SGTC_2825 7998094 58.44 µM 0.0607063130290617 0.459176760267212 no 1504 0.475796551943101 2252 2987815
SGTC_1466 k213-0079 57.5 µM 0.0604782171047035 0.459267250174776 no 1505 0.475887382159928 2301 3657981
SGTC_2045 5106652 78.05 µM 0.060427750955559 0.459287271322698 no 1506 0.475907478485332 2285 673349
SGTC_154 3389-1638 511.116 µM 0.0595281353421981 0.459644187979991 no 1507 0.476265728222191 2070 5238686
SGTC_34 0469-0683 81.75 µM 0.059425567010861 0.459684883370885 no 1508 0.476306574755023 2246 3690923
SGTC_1846 st056244 14.8 µM 0.0592718644448836 0.459745867760643 no 1509 0.4763677853121 2237 5393182
SGTC_3068 9116768 49.47 µM 0.0585986309777528 0.460012996966995 no 1510 0.476635900566246 2228 41904888
SGTC_1367 1812-0510 76.9 µM 0.0575429900145474 0.460431896178458 no 1511 0.477056330870397 2266 1142582 YDR527W RBA50
SGTC_2893 9048488 25.97 µM 0.0572203069330737 0.460559951992371 no 1512 0.477184851033757 2248 6467338
SGTC_1474 0330-0125 5.35 µM 0.0572024051055942 0.460567056398841 no 1513 0.477191981151147 2314 X1474
SGTC_1405 3909-7894 12 µM 0.0563786065690043 0.46089399747666 no 1514 0.477520099664204 2303 7104060
SGTC_1218 1348-1416 30.7 µM 0.0548411949167277 0.461504220857753 no 1515 0.47813249048464 2302 6787668
SGTC_3273 9137859 49.47 µM 0.0547998489186913 0.461520633006569 no 1516 0.478148960384368 2335 2377234
SGTC_228 caffeine 993.056 µM 0.0546824629478762 0.461567229312751 no 1517 0.478195720498172 2308 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1299 1079-1439 3.74 µM 0.0544423648372992 0.46166253778781 no 1518 0.478291363312629 2281 323161
SGTC_3334 9142812 21.919 µM 0.0543518409724364 0.461698472384677 no 1519 0.478327423718031 2282 45283678
SGTC_3158 9100007 49.47 µM 0.0535678559951188 0.462009698219016 no 1520 0.478639733462858 2265 19297233
SGTC_914 3820-6779 408 µM 0.0525672528031525 0.462406950775421 no 1521 0.47903835467845 2318 2893481
SGTC_763 3453-1109 128 µM 0.0520713783320263 0.462603833348921 no 1522 0.479235909399284 2313 1560353
SGTC_254 nsc-64875 3.808 µM 0.0514227017001532 0.462861398493536 no 1523 0.479494347680432 2293 56993
SGTC_1660 st012960 28.1 µM 0.0514119429322996 0.462865670528024 no 1524 0.479498634137925 2251 24207266
SGTC_2056 5235370 200 µM 0.0501469113562115 0.463368012283818 no 1525 0.480002658441034 2277 5511916
SGTC_1434 4073-0095 163 µM 0.0495757864590658 0.463594824137603 no 1526 0.480230221252803 2314 24133745
SGTC_425 3825-7017 13.1 µM 0.0492183973443911 0.463736760741147 no 1527 0.480372625036627 2251 3397440
SGTC_469 w7 172 µM 0.0491756065318761 0.463753755364233 no 1528 0.480389675454513 2321 45115570 A P450 inhibitor.
SGTC_860 0443-0016 25.1 µM 0.049082328685871 0.463790801439058 no 1529 0.480426843049135 2335 5337942
SGTC_878 0828-0289 13.7 µM 0.0490734185628692 0.463794340185185 no 1530 0.480430393395599 2307 745350 YLR208W SEC13
SGTC_124 0136-0217 7.121 µM 0.048726318362804 0.463932196792441 no 1531 0.480568700881125 2337 3976905
SGTC_2168 5727979 200 µM 0.0485630466784184 0.463997044351261 no 1532 0.480633759838919 2312 695210
SGTC_309 k408-0051 1.48 µM 0.0475448588572477 0.464401465408192 no 1533 0.481039489270502 2285 3640463
SGTC_19 0279-0214 38.434 µM 0.0474529726192899 0.464437964153683 no 1534 0.481076105246978 2319 3566274 YBR002C RER2
SGTC_869 0564-0080 44.1 µM 0.0472958016113242 0.464500395791674 no 1535 0.481138737084459 2177 6843321
SGTC_3139 9095020 49.47 µM 0.0467180856914298 0.464729884233934 no 1536 0.481368957893186 2333 25236292
SGTC_265 mycophenolic acid 32.932 µM 0.046223450522907 0.46492637949779 no 1537 0.481566075817065 2292 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1317 1273-0028 910 nM 0.045472547717265 0.465224694160562 no 1538 0.481865328002457 2309 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2108 5365811 200 µM 0.0453970819147381 0.465254675895805 no 1539 0.481895403443074 2288 780283
SGTC_1229 0139-0193 12.2 µM 0.0452234556178076 0.465323656466989 no 1540 0.481964599247152 2326 3090752
SGTC_2377 9073351 62.6 µM 0.0444947902461715 0.465613161703938 no 1541 0.4822550023237 2300 7337946 YHR072W ERG7
SGTC_1111 tnp00062 510.699 nM 0.044007648574198 0.465806717585796 no 1542 0.482449153547598 2321 676306
SGTC_3210 9128157 49.47 µM 0.0438528917611352 0.465868208767809 no 1543 0.482510833038067 2147 17590849
SGTC_1545 lovastatin 49.4 µM 0.0429709434457817 0.466218658248888 no 1544 0.482862348110998 2305 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1775 st081588 35.1725 µM 0.0418853704152175 0.466650055636802 no 1545 0.48329503944048 2322 1426443 YGL099W LSG1
SGTC_1108 betulinic acid 729.144 nM 0.0417989009405299 0.466684419554007 no 1546 0.483329505585629 2321 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2799 7812892 81.82 µM 0.0417245853905046 0.466713953566757 no 1547 0.483359127358527 2314 20205235
SGTC_2037 5169046 200 µM 0.0416724840112105 0.466734659474503 no 1548 0.483379894738915 2294 5718022
SGTC_354 2783-3500 4.88 µM 0.041522919561269 0.466794099239701 no 1549 0.48343951072045 2294 6740761
SGTC_2349 9023730 187.07 µM 0.0413652245301074 0.466856771054983 no 1550 0.483502367930417 2311 4126287
SGTC_870 0573-2213 57.6 µM 0.0396761233115851 0.467528111912743 no 1551 0.484175668760693 2337 3916321
SGTC_3280 9140961 49.47 µM 0.0389299970696591 0.467824692662723 no 1552 0.484473100243734 2310 4901226
SGTC_364 0083-0097 67.7 µM 0.0369931831439346 0.46859464764638 no 1553 0.485245220542439 2296 5207356
SGTC_123 0083-0120 66.675 µM 0.0369336423783564 0.468618319173148 no 1554 0.48526895764976 2320 16001701
SGTC_3204 9114183 49.47 µM 0.0345380596114003 0.469570818301524 no 1555 0.486224046630033 2335 17027248
SGTC_635 k038-0028 24.7 µM 0.0341889435973862 0.469709643745526 no 1556 0.486363241559632 2301 4035102
SGTC_397 arbidol 50 µM 0.0338223081269464 0.469855439738023 no 1557 0.486509423403958 2337 131410 A RNA synthesis inhibitor.
SGTC_1046 2001-0062 216 µM 0.033339913112229 0.470047274740031 no 1558 0.4867017626891 2328 739778
SGTC_1704 st028805 70.8 µM 0.0330759687971638 0.470152240955566 no 1559 0.48680700319185 2289 2876101
SGTC_862 0452-0056 10.2 µM 0.0330623227246277 0.470157667825587 no 1560 0.486812444211269 2339 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1454 4239-0054 42.6 µM 0.0329185575039142 0.47021484176759 no 1561 0.486869767033529 2333 1340767
SGTC_2930 9013230 14.89 µM 0.0325063408141899 0.470378779483902 no 1562 0.487034129732435 2339 2995857
SGTC_386 1509-0011 3.07 µM 0.032317481608377 0.470453890074189 no 1563 0.487109434089357 2345 3107280
SGTC_276 colchicine 750 µM 0.0322764940192956 0.470470191255974 no 1564 0.487125777245653 2274 2833 A microtubule depolymerizer.
SGTC_2493 resveratrol 26.09 µM 0.0297278030461832 0.471483927740143 no 1565 0.488142069046294 2351 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1701 st028638 40.4 µM 0.0297235690037907 0.471485611977177 no 1566 0.488143757438711 2356 3490878
SGTC_876 0720-0963 56.8 µM 0.02864264703051 0.471915602736441 no 1567 0.488574799306386 2353 765861
SGTC_2120 5538279 151.968 µM 0.0274637241161757 0.472384615575879 no 1568 0.489044936444082 2350 2058197
SGTC_3064 1327-0027 10 µM 0.0260504105085298 0.472946926863712 no 1569 0.489608565152277 2325 16000455 YPR107C YTH1
SGTC_2068 5226020 147 µM 0.0254343021815246 0.473192073169337 no 1570 0.489854275383587 2355 1810509
SGTC_2766 oltipraz 83.91 µM 0.0253671579124874 0.473218790140734 no 1571 0.489881053431435 2357 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3082 9117008 49.47 µM 0.0232399244836419 0.474065286507976 no 1572 0.490729446032884 2347 41448529
SGTC_3024 9090631 49.47 µM 0.0212824346817829 0.47484433984139 no 1573 0.491510177879931 2373 25236383
SGTC_727 3032-0951 202 µM 0.0206450245096123 0.475098041006171 no 1574 0.491764411872009 2346 3652836
SGTC_2022 5136654 200 µM 0.020343723087586 0.475217968125742 no 1575 0.491884588507039 2346 1713771
SGTC_186 3455-3465 67.277 µM 0.0203048172345816 0.475233454001119 no 1576 0.491900106491372 2382 755278
SGTC_1450 4112-4260 37.6 µM 0.0202982698027633 0.475236060109158 no 1577 0.491902718000527 2367 1633175
SGTC_1699 st031318 29.054 µM 0.0199287932084189 0.475383126496223 no 1578 0.4920500880222 2345 5340658
SGTC_1006 4099-6547 255 µM 0.0194790507610021 0.475562146410849 no 1579 0.492229474471969 2353 3146833
SGTC_815 1582-0027 36.9 µM 0.0192082712889609 0.475669932521229 no 1580 0.492337479643273 2345 3128206
SGTC_3338 9144300 39.5675 µM 0.018064181057957 0.476125367091617 no 1581 0.49279382633061 2351 4901274
SGTC_2414 st077232 92.9 µM 0.0173743469022069 0.476399988448086 no 1582 0.49306898713652 2353 729801
SGTC_3235 9132602 49.47 µM 0.0165847252895873 0.476714348708197 no 1583 0.493383955168485 2342 4912240
SGTC_2124 5246320 200 µM 0.0158016127583396 0.477026131918868 no 1584 0.493696330901463 2366 579342
SGTC_1256 0570-0116 285 µM 0.0152025325708686 0.477264655221781 no 1585 0.493935300598386 2365 410638
SGTC_178 4092-0806 87.505 µM 0.0149792536693492 0.477353555627994 no 1586 0.494024365850121 2388 2169044
SGTC_1859 st055998 20 µM 0.0137264799797106 0.477852378973563 no 1587 0.494524098733682 2380 676301
SGTC_65 0798-0905 34.986 µM 0.0127559452407968 0.478238845678166 no 1588 0.494911252119207 2380 3602145
SGTC_2131 toluylene red 5.2905 µM 0.0120406012141618 0.478523708621226 no 1589 0.495196611157244 2374 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3003 9075612 71.4286 µM 0.0117394030963064 0.478643654455834 no 1590 0.495316763327394 2363 6501993
SGTC_116 0155-0182 31.788 µM 0.0114214962048883 0.478770256307118 no 1591 0.495443581323214 2374 771486
SGTC_839 0122-0028 230 µM 0.0104346126736737 0.479163282081369 no 1592 0.49583726736551 2387 759448
SGTC_2275 7947463 200 µM 0.0104011733466393 0.479176599630344 no 1593 0.495850607002979 2390 1225414
SGTC_1844 rapamycin 4 nM 0.0103881319690933 0.479181793496678 no 1594 0.495855809478809 2381 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3229 9132204 49.47 µM 0.0103281278398084 0.479205690820388 no 1595 0.495879746378836 2385 17682924
SGTC_1575 cyproterone acetate 48 µM 0.00962659999241376 0.479485087749601 no 1596 0.496159601562473 2378 9880 An androgen receptor antagonist and liver toxin.
SGTC_2971 9092186 9.93 µM 0.00787234697894026 0.480183796500573 no 1597 0.49685942038311 2383 25236400
SGTC_1615 st002656 86.5 µM 0.00779164027350194 0.480215942992468 no 1598 0.496891616712734 2389 1584458
SGTC_3341 9147222 25.867 µM 0.00694060469454257 0.480554928917154 no 1599 0.497231121566211 2383 1939759
SGTC_2774 tamoxifen 10.92 µM 0.0059159197681426 0.480963101779358 no 1600 0.49763990324352 2394 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2657 nystatin 74.44 µM 0.0051828429423146 0.481255127780449 no 1601 0.497932354074438 2391 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1514 1189-1591 158 µM 0.00476343152134236 0.481422207627264 no 1602 0.498099672952834 2392 767698 YMR146C TIF34
SGTC_3282 9108498 15.4605 µM 0.00469519681365911 0.481449390421319 no 1603 0.49812689435829 2393 16459645
SGTC_1695 st026914 34.495 µM 0.00449466288184526 0.481529278014973 no 1604 0.498206894977666 2395 3289191
SGTC_1055 3448-0672 86 µM 0.00358230377342256 0.481892747883953 no 1605 0.498570870620187 2389 748378
SGTC_2032 5185112 25.99 µM 0.00316992965802317 0.482057036360922 no 1606 0.498735383151424 2401 5718189
SGTC_1934 st074720 32.6 µM 0.00234358954988744 0.482386256656078 no 1607 0.499065043896504 2402 17250992
SGTC_1085 doxorubicin 7.67 µM 0.00117600515383943 0.482851451739744 no 1608 0.499530841930303 2399 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_418 lividomycin a 100 µM 0.000680426495738972 0.483048909876071 no 1609 0.49972854912309 2404 72394 An antibiotic.
SGTC_684 1140-0066 328 µM 0.000611154103378267 0.483076511069055 no 1610 0.499756184803499 2403 6813534
SGTC_2977 9011197 71.43 µM 0.00046684144067206 0.483134011893713 no 1611 0.499813757217837 2405 2704722
SGTC_2894 9048625 32.47 µM 0.000318153326440315 0.483193256467082 no 1612 0.499873075188574 2404 4092861
SGTC_1109 tnp00067 928.257 nM 0 0.483320025464618 no 1613 0.5 2406 676295
SGTC_1762 st045503 25.4615 µM -0.000275586445132984 0.483429834944007 no 1614 0.499890056916523 2407 4645554
SGTC_316 k060-0003 58.6 µM -0.000661344520229077 0.483583545242153 no 1615 0.499736161728202 2408 6152314
SGTC_1563 conessine 56.1 µM -0.000753149295594068 0.483620126403459 no 1616 0.499699536930938 2411 441082 An anti-amoebic, histamine inhibitor.
SGTC_3163 9099914 49.47 µM -0.00125411552224658 0.483819747267721 no 1617 0.499499680424819 2407 16268368
SGTC_2367 9070478 135.38 µM -0.00127709921094063 0.483828905714925 no 1618 0.499490511266983 2411 572802
SGTC_3209 9113616 49.47 µM -0.00264339572097081 0.484373357175449 no 1619 0.498945438911204 2408 16649353
SGTC_546 peri-Naphthalide 147 µM -0.00333920658814926 0.484650640053706 no 1620 0.498667851784635 2417 223824 A penicillin ester.
SGTC_3048 9093155 49.47 µM -0.00336818598560553 0.48466218859914 no 1621 0.498656290742745 2408 25236002
SGTC_1371 2421-0008 32.7 µM -0.00361129945546681 0.484759071966474 no 1622 0.498559303091495 2413 2827552
SGTC_1772 st048439 82.2 µM -0.0039914165075891 0.484910554555494 no 1623 0.498407659424469 2416 2927068 YDL195W SEC31
SGTC_1401 3807-4679 7.6 µM -0.00408379272851228 0.484947368253737 no 1624 0.498370806944642 2410 3291456
SGTC_2571 chrysanthemic acid 100 µM -0.00634046582074618 0.485846734913514 no 1625 0.497470537054713 2425 2743 An insecticide.
SGTC_3023 9089636 49.47 µM -0.00651246536912419 0.485915286026964 no 1626 0.497401920579665 2420 17249241
SGTC_2737 bleomycin 30.5 nM -0.00702153931336758 0.486118181931103 no 1627 0.497198834111603 2413 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1493 4348-0038 111 µM -0.00730119308901728 0.48622964193907 no 1628 0.497087271257782 2421 800424
SGTC_2673 kobusone 100 µM -0.00773046941128907 0.486400738240835 no 1629 0.496916019621043 2420 6710676 An epoxy ketone and protein crosslinker.
SGTC_419 nsc-638432 893 µM -0.00810716966886594 0.486550881408104 no 1630 0.496765742673981 2430 368090
SGTC_456 gingerol 170 µM -0.0087819517113016 0.486819837165733 no 1631 0.496496553190508 2432 442793 A herb.
SGTC_1853 st056710 91.2 µM -0.009310840242749 0.487030646640204 no 1632 0.496285565829646 2419 269167
SGTC_1875 nocodazole 6 µM -0.00954608096354879 0.487124412315733 no 1633 0.496191722531497 2420 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2116 5511452 16.8835 µM -0.0105103991714804 0.487508791706899 no 1634 0.495807034585169 2437 870744
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0108333742779973 0.487637532917343 no 1635 0.495678193497233 2418 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1172 0370-0043 85 µM -0.0110478181398641 0.487723013166138 no 1636 0.49559264789404 2437 376585
SGTC_2253 7938677 135.83 µM -0.0117688905005693 0.488010446560048 no 1637 0.495305000367708 2436 2301972
SGTC_651 3253-0966 34.4 µM -0.0129966522746433 0.488499870406323 no 1638 0.494815231866811 2432 781462
SGTC_1730 st033808 45.1 µM -0.0134562808117318 0.488683097062954 no 1639 0.494631882649905 2455 1045166
SGTC_528 3492-0019 172 µM -0.0142986345122268 0.489018899730984 no 1640 0.494295864511047 2422 2869262
SGTC_1272 0839-0021 27 µM -0.0151165750183958 0.489344977577901 no 1641 0.493969588760233 2452 5027250
SGTC_222 nsc-310342 10.666 µM -0.0158729152591332 0.489646504379747 no 1642 0.493667888886326 2433 432556
SGTC_68 0986-0284 82.829 µM -0.0166775916081475 0.489967307615606 no 1643 0.493346911990941 2543 423278 YIL048W NEO1
SGTC_2290 7904846 200 µM -0.0167364309078184 0.489990765549571 no 1644 0.493323441782337 2448 2962154
SGTC_3230 9131665 49.47 µM -0.0168891120442987 0.490051636320074 no 1645 0.493262539429855 2438 15943720
SGTC_1242 0402-0103 60.1 µM -0.0182708537511263 0.490602518155336 no 1646 0.492711389460872 2447 432868
SGTC_161 4065-0411 162.148 µM -0.0184995270098941 0.490693688865158 no 1647 0.492620177446579 2451 1906281 YLR208W SEC13
SGTC_215 1287-0124 461.5 µM -0.0213331589129663 0.491823480409102 no 1648 0.491489946432758 2500 5560863
SGTC_1907 st060210 83.7 µM -0.0219578646650318 0.492072564695602 no 1649 0.491240783276317 2446 688793
SGTC_1763 st044482 94.5 µM -0.022011388512817 0.492093906007197 no 1650 0.491219435509994 2485 88505
SGTC_1179 1021-1431 9.29 µM -0.0224239329432596 0.492258398658681 no 1651 0.491054894711005 2466 2840958
SGTC_2363 9053361 176 µM -0.0226791243146435 0.492360151039363 no 1652 0.490953113968323 2455 6469797 YMR079W SEC14
SGTC_1993 st073995 70.8 µM -0.0241849876282389 0.492960593378466 no 1653 0.490352526383074 2487 3098394
SGTC_3052 9092717 49.47 µM -0.0250531003609098 0.493306748757137 no 1654 0.490006304458716 2493 25237534
SGTC_1552 6-methylflavone 10.6 µM -0.0257691678443975 0.493592280698521 no 1655 0.489720727087247 2450 689013
SGTC_2327 6189656 200 µM -0.0264312478468297 0.493856288053728 no 1656 0.48945668533678 2473 5349088
SGTC_2317 5986382 200 µM -0.0267725558918401 0.493992387218094 no 1657 0.489320571297477 2462 877883
SGTC_3243 9134147 49.47 µM -0.029446140476048 0.495058522237649 no 1658 0.488254386982259 2453 24282180
SGTC_2111 5486399 200 µM -0.0306397470494894 0.495534503980121 no 1659 0.487778421728661 2452 689674
SGTC_985 1493-0307 8.71 µM -0.0321296547879402 0.496128652379406 no 1660 0.487184327256245 2470 3278274
SGTC_424 splitomicin 100 mM -0.0322273171699775 0.496167598694431 no 1661 0.487145385769159 2522 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2473 5854593 8.94 µM -0.0341418136724576 0.496931078525092 no 1662 0.486382032708954 2466 2872951
SGTC_3316 9136639 10.545 µM -0.0341684358463542 0.496941695236536 no 1663 0.486371418191299 2547 4903665
SGTC_1313 1220-0047 237 µM -0.0347932167641261 0.497190853508548 no 1664 0.486122314798207 2487 3528706
SGTC_2252 omeprazole 400 µM -0.0349834905228633 0.497266733578474 no 1665 0.486046452734709 2534 4594 A proton pump inhibitor.
SGTC_2094 5332512 191.667 µM -0.036266501537972 0.497778393364169 no 1666 0.485534930129622 2496 755774
SGTC_3237 9133362 49.47 µM -0.0369149377908486 0.498036988654201 no 1667 0.485276414615396 2465 43845137
SGTC_3151 9099821 49.47 µM -0.0378847670464606 0.498423756440487 no 1668 0.484889779233202 2515 17174189
SGTC_2699 st077704 54.6 µM -0.0380481575912275 0.498488916725122 no 1669 0.4848246427992 2506 645852
SGTC_1954 st077032 68.9 µM -0.038205697276068 0.498551743720163 no 1670 0.484761839222339 2536 698907
SGTC_1089 terbinafine 2.25 µM -0.0382364197405009 0.498563995876116 no 1671 0.484749591681493 2484 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1260 0700-1617 7.75 µM -0.038307513251432 0.49859234805939 no 1672 0.4847212502382 2497 2853078
SGTC_2741 miltefosine 3.04 µM -0.0388188795867885 0.498796281810078 no 1673 0.484517396222544 2492 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2517 totarol 10 µM -0.039395058692868 0.49902606337642 no 1674 0.484287709722492 2519 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2525 harmine 47.85 µM -0.0397518301199746 0.499168344817386 no 1675 0.484145489922337 2522 5280953 A monoamine oxidase inhibitor
SGTC_2813 7971799 71.43 µM -0.0410211767289353 0.499674564520699 no 1676 0.483639506740698 2526 2234054
SGTC_1840 st055363 71 µM -0.0414417435214563 0.499842288129826 no 1677 0.483471867423453 2528 676033
SGTC_1348 1493-0373 93.8 µM -0.0416116046494141 0.499910029392247 no 1678 0.483404161041602 2506 3010129
SGTC_281 1672-3440 14.9 µM -0.0420628069962497 0.499910029392247 no 1679 0.483224314815934 2491 6833000
SGTC_1160 4092-0570 10.5 µM -0.0424222377875925 0.499766687034145 no 1680 0.48308105055677 2487 4994975
SGTC_2784 7567673 72.73 µM -0.0434286803983627 0.499365314136324 no 1681 0.482679907805568 2478 3471247
SGTC_2552 juarezic acid 87.02 µM -0.0444358730607153 0.498963642758523 no 1682 0.482278483655298 2474 1549512
SGTC_172 1112-0046 2.638 µM -0.046914680240897 0.497975092528588 no 1683 0.481290613918627 2507 2802135 YIL048W NEO1
SGTC_932 2857-0803 154 µM -0.0469690175615642 0.497953422879971 no 1684 0.481268960334398 2679 674898
SGTC_1368 1852-0141 284 µM -0.047456613131098 0.49775897071646 no 1685 0.481074654527295 2528 2838987
SGTC_608 k048-0125 159 µM -0.0478623269455309 0.497597173241262 no 1686 0.480912981852073 2483 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2999 9069765 71.4286 µM -0.0480325641004042 0.497529283281079 no 1687 0.480845145075149 2522 2097066
SGTC_694 1315-0438 43.2 µM -0.0482713388780906 0.497434060886401 no 1688 0.480749998089422 2524 6793154
SGTC_611 3453-1652 23.7 µM -0.0486418190228133 0.49728631522694 no 1689 0.480602371315054 2495 1560575
SGTC_1749 st037932 54.2 µM -0.048815109402962 0.497217208002218 no 1690 0.480533320483725 2567 594497
SGTC_1651 st011928 86.1 µM -0.0489278162405675 0.497172261196727 no 1691 0.480488410624774 2557 720198
SGTC_708 3448-5400 146 µM -0.0498172911741674 0.496817545275783 no 1692 0.480133993713454 2488 3462195
SGTC_1937 st074714 47.2 µM -0.0507558761048757 0.496443247390807 no 1693 0.479760025647697 2492 17250970
SGTC_6 0844-0013 19.835 µM -0.0508140342244406 0.496420054638689 no 1694 0.479736853815504 2510 1584900
SGTC_2597 laccaic acid a 100 µM -0.0508146727085084 0.496419800019061 no 1695 0.479736599425855 2530 5491415 A textile dye.
SGTC_1642 st009582 77.7 µM -0.0518958771977397 0.495988631082948 no 1696 0.479305829685358 2511 6739311
SGTC_1246 0422-0085 105 µM -0.0528709350527558 0.495599795915567 no 1697 0.478917371231433 2515 264295
SGTC_1458 k015-0034 6.33 µM -0.054010535564841 0.495145349482467 no 1698 0.47846338516417 2535 3598957
SGTC_2409 alverine citrate 63.97 µM -0.0540631592487692 0.495124364517169 no 1699 0.478442421980104 2781 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_788 1182-0090 188 µM -0.0550152963352562 0.494744679238921 no 1700 0.478063138767706 2690 5715185
SGTC_2495 cafestol 54.53 µM -0.0551225617161223 0.494701905137865 no 1701 0.478020410909192 2675 16667697 An anti-infammatory.
SGTC_381 3461-2219 42.7 µM -0.0558792659265334 0.494400156769002 no 1702 0.477718994205455 2529 2883159
SGTC_2103 5378138 10 µM -0.0565561432597523 0.494130243402654 no 1703 0.477449385600126 2496 244142
SGTC_147 4466-0538 29.23 µM -0.0570202224134798 0.493945187537301 no 1704 0.477264543095416 2651 6742687 YHR072W ERG7
SGTC_1273 0849-0096 14.1 µM -0.0576966964470925 0.493675439589221 no 1705 0.476995112583915 2534 5286025
SGTC_2714 st079313 56.9 µM -0.0586183981984396 0.493307910343588 no 1706 0.476628028118529 2509 2939799
SGTC_153 4077-0274 519.67 µM -0.0598005299908104 0.492836542787228 no 1707 0.476157251731247 2520 3121976
SGTC_3227 9130768 49.47 µM -0.0611867817509324 0.492283796478546 no 1708 0.475605228321588 2520 17720899
SGTC_1783 st039459 87.517 µM -0.0612347983517698 0.492264650865834 no 1709 0.475586108321959 2653 729761
SGTC_2100 5377183 190 µM -0.0621002154584845 0.491919587039463 no 1710 0.475241512710098 2578 2844202
SGTC_248 streptozotocin 5.23457 mM -0.062511807965848 0.491755476737209 no 1711 0.475077629467266 2603 5300 DNA alkylating agent.
SGTC_3255 9139072 49.47 µM -0.0632253607329614 0.491470972062037 no 1712 0.474793525115716 2578 17646060
SGTC_1174 0739-0097 51.1 µM -0.0633393579637155 0.491425519977125 no 1713 0.474748137771964 2551 728447
SGTC_2616 abietic acid 100 µM -0.0646614958997802 0.490898375758125 no 1714 0.474221760227276 2525 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3128 9127691 49.47 µM -0.0657971372969627 0.490445601469246 no 1715 0.473769667702658 2649 41316314
SGTC_2033 5192550 145 µM -0.0664668453287986 0.49017859811103 no 1716 0.473503076456502 2549 182073
SGTC_203 k066-0004 30.888 µM -0.0669990680528424 0.489966411382053 no 1717 0.473291222560509 2493 6795412
SGTC_1492 4158-0558 28.5 µM -0.0671759703810247 0.489895884530041 no 1718 0.473220807380858 2616 3967268
SGTC_2449 5812982 45.77 µM -0.0691025089866367 0.489127839231199 no 1719 0.472454011961082 2505 776185
SGTC_2750 bromebric acid 70.15 µM -0.0693250977496516 0.489039103219617 no 1720 0.472365424338631 2598 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_50 0929-0078 56.389 µM -0.0713158812943934 0.488245493047762 no 1721 0.471573177983303 2626 1377751
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0722731332443985 0.487863908477351 no 1722 0.471192272666993 2541 641818 YHR062C RPP1
SGTC_1979 st071809 45.3 µM -0.0729511904634367 0.487593624611196 no 1723 0.470922479163919 2661 4976333
SGTC_49 0717-0965 32.132 µM -0.0731042075371383 0.487532630474171 no 1724 0.470861596744631 2800 5889349 YGL099W LSG1
SGTC_550 4123-0385 25.7 µM -0.0749017342497556 0.486816140552645 no 1725 0.470146448351843 2560 5731123
SGTC_3109 9122853 49.47 µM -0.0771193685181324 0.485932255628584 no 1726 0.469264292517884 2603 1234709
SGTC_2812 7970281 58.44 µM -0.0781631454545128 0.485516259962693 no 1727 0.468849138980078 2620 2233435
SGTC_1277 0873-0036 22 µM -0.0787738488428545 0.485272872362058 no 1728 0.468606252496765 2613 5965735
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0790290389932712 0.485171171388654 no 1729 0.468504762757707 2542 229346 A bile salt which induces apoptosis.
SGTC_629 3448-6466 76.7 µM -0.0791101381740493 0.485138851120213 no 1730 0.468472509845947 2565 573744
SGTC_3111 9122088 49.47 µM -0.0794938664770559 0.484985926096927 no 1731 0.468319905009065 2634 16876704
SGTC_1147 3809-1045 12.3 µM -0.0800819151305093 0.484751578757658 no 1732 0.468086053090788 2553 325925
SGTC_1807 st050092 58.9 µM -0.0801915653825021 0.484707881856914 no 1733 0.468042449204094 2557 5008496
SGTC_1324 1418-0026 34.4 µM -0.0802918980200865 0.484667898294767 no 1734 0.468002550927082 2647 1372513
SGTC_2364 9055074 200 µM -0.0803236366443406 0.484655250166826 no 1735 0.46798992981255 2588 6470630
SGTC_1211 1056-0033 32.3 µM -0.0805594316545276 0.484561284213456 no 1736 0.467896165073319 2568 6741922
SGTC_2437 5741531 144.16 µM -0.0809025057563423 0.484424568327712 no 1737 0.467759743597362 2618 2262990
SGTC_2640 pentamidine 10.38 µM -0.0815403610219551 0.484170386291611 no 1738 0.467506114135453 2591 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2177 5811945 192 µM -0.0817776648286074 0.484075823583847 no 1739 0.467411758729016 2643 5343475
SGTC_1411 3909-8223 150 µM -0.082481767192895 0.483795252566831 no 1740 0.467131808299359 2559 X1411
SGTC_1792 st045773 43.6 µM -0.0826674736097938 0.483721253524402 no 1741 0.467057974308645 2552 2919270
SGTC_2170 morpholine 200 µM -0.082765145650429 0.48368233405223 no 1742 0.467019141875049 2625 121171 Reacts with secondary amines.
SGTC_3113 9123498 49.47 µM -0.0840203671863425 0.483182178685044 no 1743 0.466520119175738 2540 8897275
SGTC_1785 bathophenanthroline 24 µM -0.0843370489951539 0.483055997853045 no 1744 0.466394228239427 2573 72812 An iron chelator.
SGTC_1939 st074455 53.6 µM -0.0849084990683191 0.482828309741272 no 1745 0.466167067455789 2581 1644229
SGTC_1344 1488-0097 29.1 µM -0.0857356675115751 0.482498743345371 no 1746 0.465838273965793 2633 747966
SGTC_1640 st009078 66.4 µM -0.0859630438907229 0.482408152500156 no 1747 0.465747897571244 2597 690618
SGTC_290 2043-6722 48.1 µM -0.0861435625974093 0.482336231242273 no 1748 0.465676147181219 2610 773758 YLR208W SEC13
SGTC_2309 7664088 163.95 µM -0.0870868239145482 0.481960431723826 no 1749 0.465301249292947 2581 704922
SGTC_2641 levomentholum 100 µM -0.0877865704430736 0.481681659921093 no 1750 0.465023155893666 2562 16666
SGTC_1370 2001-0092 44.6 µM -0.0882401123581931 0.481500978273645 no 1751 0.464842918294598 2606 790957
SGTC_1945 st075991 56.6 µM -0.0882557837756622 0.481494735175213 no 1752 0.464836690600557 2600 1084980
SGTC_552 k242-0005 476 µM -0.0893322608089048 0.481065904754248 no 1753 0.464408928067793 2662 4088318
SGTC_2718 lomofungin 53.02 µM -0.0900085105776619 0.480796521909983 no 1754 0.464140225909734 2642 5351222 A RNA synthesis inhibitor.
SGTC_2829 7992743 58.44 µM -0.0912246556229136 0.480312094928712 no 1755 0.463657042138924 2609 16462845
SGTC_534 k292-0788 63.4 µM -0.091945045946701 0.480025155561697 no 1756 0.46337085076278 2548 4146317
SGTC_490 phenamil 164 µM -0.0925101009741011 0.479800095182684 no 1757 0.463146383110046 2667 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2846 9008642 19.48 µM -0.0942009202113468 0.479126683736147 no 1758 0.462474776901707 2697 2992898
SGTC_631 k072-0230 41.5 µM -0.0944402678016921 0.479031362285312 no 1759 0.462379714824214 2665 5773147
SGTC_2314 7727897 200 µM -0.0961423077838794 0.478353550717306 no 1760 0.461703775082512 2594 900724
SGTC_2953 9074162 66.49 µM -0.0962959389414454 0.478292372493764 no 1761 0.46164276817749 2605 16451992
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0963529027917541 0.47826968876694 no 1762 0.46162014807207 2583 165521
SGTC_1080 nisoldipine 24.4 µM -0.0976999843093365 0.477733284518238 no 1763 0.46108526400894 2570 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1100 amiodarone 5.07 µM -0.0989152843606282 0.477249389878864 no 1764 0.460602766628585 2582 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_740 k014-0057 261 µM -0.0996039690515057 0.476975191922322 no 1765 0.460329371325699 2681 4012779
SGTC_831 k061-1017 217 µM -0.100571409974807 0.476590026363374 no 1766 0.459945346570473 2664 1240153
SGTC_2396 5342950 42.78 µM -0.101605531605947 0.476178337523264 no 1767 0.45953489429483 2635 1886677
SGTC_162 k030-0015 37.8 µM -0.102179913535533 0.475949684245113 no 1768 0.459306935486517 2641 1809920 YMR134W ERG29
SGTC_1127 asiatic acid 681.4 nM -0.102393836005654 0.475864526771844 no 1769 0.459222038056448 2595 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2600 tangeritin 87.95 µM -0.102452373923575 0.475841224403853 no 1770 0.459198806978841 2607 68077 A bioactive flavone.
SGTC_2106 5357045 167.29 µM -0.102727083750377 0.475731870928068 no 1771 0.45908978881569 2696 668842
SGTC_2319 6033012 152.6 µM -0.103098934279862 0.4755838516597 no 1772 0.458942225419451 2621 847246
SGTC_1510 1123-0200 71.5 µM -0.103597597488023 0.475385358476935 no 1773 0.45874434716623 2767 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1159 4092-0538 61.2 µM -0.103795490250092 0.475306588837228 no 1774 0.458665822699302 2592 717301
SGTC_710 3448-4187 58 µM -0.103803013070888 0.475303594457277 no 1775 0.458662837652285 2602 3946412
SGTC_2946 9065502 71.43 µM -0.104017403286867 0.47521825926636 no 1776 0.45857776883084 2567 16489101
SGTC_2011 4012611 177 µM -0.105736548364768 0.474534017734034 no 1777 0.457895690740344 2599 2049887
SGTC_674 0498-0004 451 µM -0.106293004421911 0.474312557162972 no 1778 0.457674940905279 2615 4231473
SGTC_2677 mitomycin C 100 µM -0.106737538153773 0.474135645579261 no 1779 0.457498600782412 2606 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_583 1488-1091 88.9 µM -0.108299371087609 0.473514121859952 no 1780 0.45687911074121 2574 4303273
SGTC_1991 st073000 8.92 µM -0.108352785333275 0.473492867055618 no 1781 0.456857926201001 2787 4301969 YIL048W NEO1
SGTC_2411 st077133 39.94 µM -0.109774854313781 0.472927019775656 no 1782 0.456293966924659 2900 1403142 YNL221C POP1
SGTC_2383 9036125 200 µM -0.109976381170146 0.472846835777499 no 1783 0.456214053185362 2595 79580
SGTC_1287 0971-0001 34.6 µM -0.110230564732364 0.472745702170032 no 1784 0.456113261408993 2597 4665869
SGTC_2130 NSC 7 2.4545 µM -0.111050801705536 0.472419361358364 no 1785 0.455788030945685 2674 21448
SGTC_1316 1272-0050 65.9 µM -0.111377761739482 0.472289281657832 no 1786 0.455658396945419 2613 7340392
SGTC_82 0054-0107 293.755 µM -0.112212854844094 0.471957056758697 no 1787 0.455327318426744 2693 3104697
SGTC_3005 9076496 71.4286 µM -0.112974704074838 0.47165398746629 no 1788 0.455025305010956 2633 21368410
SGTC_2594 a-mangostin 100 µM -0.113712059326588 0.471360677689433 no 1789 0.4547330262863 2735 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_773 4358-1457 44.6 µM -0.113761864978149 0.471340866244588 no 1790 0.454713284808762 2588 1186886
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.113790015027763 0.471329668888955 no 1791 0.45470212701661 2622 16725076
SGTC_991 3996-0057 64.7 µM -0.114837675367226 0.470912953120668 no 1792 0.45428689298086 2692 715343
SGTC_1682 st012968 530 nM -0.11565677765614 0.470587170411863 no 1793 0.453962281362093 2631 24207270
SGTC_665 3914-0008 307 µM -0.115908080632906 0.470487223260412 no 1794 0.453862695722969 2607 1069549
SGTC_1596 piperlongumine 63 µM -0.116415184892963 0.47028554557753 no 1795 0.45366175070718 2748 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_677 0929-0063 136 µM -0.117969123347606 0.469667584832471 no 1796 0.453046061505959 2614 1539583
SGTC_2890 9046729 58.44 µM -0.118019023952387 0.469647741867697 no 1797 0.453026292145481 2657 903329
SGTC_3335 9143315 29.6265 µM -0.118160339997063 0.469591547982056 no 1798 0.452970306926274 2691 4899691
SGTC_1330 1469-0054 61.8 µM -0.11864278244024 0.469399710815121 no 1799 0.45277918461098 2759 7102664
SGTC_913 3487-1245 167 µM -0.120778227620565 0.468550663823918 no 1800 0.451933347842181 2609 4016153
SGTC_3315 9136395 68.55 µM -0.121136344800185 0.468408291340238 no 1801 0.451791521072763 2632 16876844
SGTC_463 ikarugamyin 104 µM -0.121603566108182 0.468222549673599 no 1802 0.451606494553322 2619 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_902 1120-0002 2.07 µM -0.12182922650812 0.468132841901783 no 1803 0.451517133473544 2630 3280475
SGTC_1526 st051518 75 µM -0.122392386763006 0.467908973395546 no 1804 0.451294133832582 2700 673993
SGTC_510 ag-490 170 µM -0.122541071358389 0.467849869710691 no 1805 0.451235260415326 2657 5328779
SGTC_2850 9015429 58.44 µM -0.122933361326461 0.467693933742324 no 1806 0.45107993373265 2668 6457570
SGTC_3102 9121669 49.47 µM -0.123192583568999 0.467590895153047 no 1807 0.450977299144797 2661 41905072
SGTC_1213 1315-0166 115 µM -0.123538957557612 0.467453217892355 no 1808 0.450840163439049 2752 768401
SGTC_1706 st031321 9.9705 µM -0.12507278975926 0.466843594951646 no 1809 0.450232962371054 2711 6103185
SGTC_588 3970-1144 52.9 µM -0.126598623461777 0.466237228182846 no 1810 0.449629043246858 2773 1888707
SGTC_145 3737-0113 38.366 µM -0.126770346961546 0.466168990092771 no 1811 0.449561083021692 2743 6849351
SGTC_1788 fluconazole 20 µM -0.128062534977773 0.465655542948936 no 1812 0.449049742311029 2716 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1685 st024049 53.0905 µM -0.128480376385671 0.465489527072796 no 1813 0.448884413442958 2695 1941139
SGTC_2457 5731572 11.68 µM -0.12858355423709 0.465448533587736 no 1814 0.448843590043004 2762 2865357
SGTC_1892 st058411 7.36 µM -0.129111327241667 0.465238850386752 no 1815 0.448634779593645 2753 3934738
SGTC_1140 3229-1848 2.98 µM -0.130267944390179 0.464779362447167 no 1816 0.448177220298383 2728 2849525
SGTC_956 1185-0240 191 µM -0.13055714658139 0.464664478746878 no 1817 0.448062822273428 2675 1416193
SGTC_2212 7123476 200 µM -0.131966304592679 0.464104742158836 no 1818 0.447505471824074 2659 1085715
SGTC_3044 9093193 49.47 µM -0.132430296390971 0.463920453843787 no 1819 0.447321976325065 2746 25236277
SGTC_1484 3473-2379 286 µM -0.132557793855559 0.463869815740466 no 1820 0.447271556693776 2635 671917
SGTC_1153 4055-0057 267 µM -0.133323065252361 0.463565885616583 no 1821 0.446968943499965 2644 882706
SGTC_2189 6047310 154.431 µM -0.134745461995387 0.463001032562225 no 1822 0.44640656373105 2620 711535
SGTC_2827 7993847 71.43 µM -0.135634394524867 0.462648063190329 no 1823 0.446055156900417 2729 2985692
SGTC_3257 9139206 32.98 µM -0.135724111197264 0.462612440926352 no 1824 0.446019693057898 2757 4910041
SGTC_3015 9080845 49.47 µM -0.135770580770572 0.462593990165871 no 1825 0.446001324405151 2748 5296973
SGTC_2533 agelasine 13.65 µM -0.136985584623147 0.462111601136835 no 1826 0.445521094747786 2738 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1288 0973-0013 65.5 µM -0.138070821070388 0.461680780332892 no 1827 0.445092223144402 2738 4315430
SGTC_1175 0741-0056 27.6 µM -0.13894415055647 0.461334115689583 no 1828 0.444747141107586 2804 765927
SGTC_2703 st077852 53.4 µM -0.139644829914406 0.461056005051187 no 1829 0.444470309240196 2785 6281836
SGTC_3339 9145883 14.936 µM -0.140038068847301 0.460899930679734 no 1830 0.444314956069776 2742 2030670
SGTC_877 0771-0151 33.1 µM -0.140876869849316 0.460567035326662 no 1831 0.443983607540044 2746 6166523
SGTC_3330 9141424 71.43 µM -0.142662100386381 0.459858622320087 no 1832 0.443278524994733 2794 27261020
SGTC_2629 bisabolol 100 µM -0.14381192009405 0.459402419582558 no 1833 0.442824494926509 2814 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3093 9117344 49.47 µM -0.145359791566249 0.45878837025142 no 1834 0.442213404554493 2817 24824913
SGTC_1658 st012944 20 µM -0.145907863393175 0.4585709705654 no 1835 0.441997061968375 2722 24207260
SGTC_1564 D-Arginine 115 µM -0.146832804853371 0.45820410886366 no 1836 0.441631995389878 2705 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2937 9044753 11.33 µM -0.147157842390896 0.458075196900148 no 1837 0.441503717576928 2657 6465530 YGL099W LSG1
SGTC_1281 0884-0031 11.8 µM -0.147688029871065 0.457864930628427 no 1838 0.441294489407871 2660 1548255
SGTC_3266 9136860 49.47 µM -0.149123282595351 0.457295785198463 no 1839 0.440728177222376 2666 4871271 YPR165W RHO1
SGTC_359 0081-0058 15.9 µM -0.150056675633859 0.456925697736078 no 1840 0.440359950358679 3031 3494159
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.150131462794941 0.456896046469462 no 1841 0.440330448785834 2677 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3203 9113543 49.47 µM -0.1507400410684 0.456654769115777 no 1842 0.44009039295336 2853 17018012
SGTC_1815 st051655 58.2 µM -0.151288422260975 0.456437371221533 no 1843 0.439874100929378 2690 5984156
SGTC_733 4069-0007 56.1 µM -0.15144810312116 0.456374070472668 no 1844 0.439811123116378 2683 5717425 YNL287W SEC21
SGTC_509 pifithrin 175 µM -0.153412714654233 0.455595349501639 no 1845 0.439036409366134 2679 4817 A p53 inhibitor.
SGTC_725 1497-0963 19 µM -0.15383674323773 0.455427297864705 no 1846 0.438869230875528 2770 3549977
SGTC_432 NS 1619 61.3 µM -0.156099510473853 0.45453065016019 no 1847 0.437977292109367 2850 4552 A K+/calcium channel activator.
SGTC_2052 5265182 7.135 µM -0.156861540068554 0.454228739028278 no 1848 0.437676985567581 2810 1239884
SGTC_263 alizarin 107.927 µM -0.157574170370479 0.453946423496865 no 1849 0.437396179158999 2662 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2440 5628896 157.78 µM -0.157957368971177 0.453794625197727 no 1850 0.43724519576817 2706 5522048
SGTC_806 3966-4455 5.86 µM -0.157965590572801 0.453791368409136 no 1851 0.437241956489776 2695 714982
SGTC_531 3788-1495 174 µM -0.15850804462512 0.453576495235389 no 1852 0.43702824105304 2647 2896655
SGTC_2685 mycophenolic acid 18.85 µM -0.158700574330873 0.453500234954848 no 1853 0.436952392831442 2740 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1854 st056233 32.9 µM -0.159299106704558 0.453263169532588 no 1854 0.436716612259523 2664 5393174
SGTC_950 1165-0508 94.1 µM -0.160223889311275 0.452896916391946 no 1855 0.436352355772538 2776 6148369
SGTC_2614 arthonioic acid 13.39 µM -0.160630398127892 0.452735934316078 no 1856 0.436192255768741 2668 6710684
SGTC_3080 9117754 49.47 µM -0.1619030951014 0.452231982314466 no 1857 0.435691082719925 2871 9550191
SGTC_1125 tnp00248 1.32998 µM -0.162459440070646 0.452011709566784 no 1858 0.435472033024769 2858 24207736
SGTC_1733 st037357 54.9 µM -0.163844371085878 0.451463440407334 no 1859 0.43492683028463 2685 1272339 YGL099W LSG1
SGTC_1949 st076024 69.1 µM -0.163877376605296 0.451450375243931 no 1860 0.434913838579637 2646 2921930
SGTC_1570 verbenone 133 µM -0.163995407319423 0.451403653471687 no 1861 0.434867379645957 2836 29025 A natural terpanoid with antifungal properties.
SGTC_1751 st044839 27.194 µM -0.164194298818167 0.451324924951044 no 1862 0.434789094541476 2665 5291326
SGTC_623 k072-0108 16.9 µM -0.164605905934727 0.451162001902923 no 1863 0.434627091184532 2782 5382803
SGTC_910 3454-3003 490 µM -0.167117450356156 0.450168057255201 no 1864 0.43363881785056 2729 820824
SGTC_549 1661-1316 519 µM -0.167489090160198 0.450021007054341 no 1865 0.433492615534988 2767 2857282
SGTC_1977 st070720 65.3 µM -0.16877890679404 0.449510706591948 no 1866 0.432985275113192 2814 682188
SGTC_3254 9136651 49.47 µM -0.169188507280579 0.449348670504513 no 1867 0.432824184668593 2702 16454030
SGTC_3175 9106517 49.47 µM -0.169644710376724 0.449168208580466 no 1868 0.432644779176767 2801 41468073
SGTC_2778 tioconazole 65.09 nM -0.170653219684689 0.44876930623896 no 1869 0.43224822420367 2680 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_506 n9-isopropylolomoucine 153 µM -0.171080989671198 0.448600123170658 no 1870 0.432080041768796 2766 6610355
SGTC_360 0957-0399 1.01 µM -0.171538580129842 0.448419156450605 no 1871 0.431900148715473 2844 6752301 YPR165W RHO1
SGTC_3242 9133940 49.47 µM -0.171583789566624 0.448401277718573 no 1872 0.43188237624442 2867 17248444
SGTC_2079 5212404 121 µM -0.17167300870309 0.448365995015583 no 1873 0.431847303340519 2763 758462
SGTC_2077 5212015 200 µM -0.172862280944609 0.447895723153578 no 1874 0.431379840352229 2670 780900
SGTC_1947 st076332 61.6 µM -0.1730101702186 0.447837248659767 no 1875 0.431321716748491 2798 24208416
SGTC_1464 k208-0027 110 µM -0.173010535249813 0.447837104330111 no 1876 0.431321573285365 2892 X1464
SGTC_2243 6634756 200 µM -0.173958062926921 0.447462484782928 no 1877 0.430949210288433 2996 885676
SGTC_946 3434-1334 87.4 µM -0.174061607773521 0.447421549579872 no 1878 0.430908522558371 2850 4047976
SGTC_742 0kpi-0133 140 µM -0.174092783604678 0.447409224701675 no 1879 0.430896272224592 2876 2728852
SGTC_845 0330-0138 4.51 µM -0.174607306071909 0.447205823619722 no 1880 0.430694103683887 2796 9039800
SGTC_235 0330-0087 5 mM -0.17553075419339 0.446840800858331 no 1881 0.430331303773304 2733 46494818 YHR062C RPP1
SGTC_3300 9124615 50.48 µM -0.176519412620567 0.446450051534258 no 1882 0.42994294953346 2898 24824903
SGTC_693 4161-2696 114 µM -0.17661115138826 0.446413796079288 no 1883 0.429906917121216 2830 805759
SGTC_181 1447-1644 8.07 µM -0.177157183746928 0.446198011619371 no 1884 0.429692463029818 2782 534600
SGTC_515 4092-1064 102 µM -0.177922837468753 0.445895462672506 no 1885 0.429391787646304 2920 717353
SGTC_2127 5253358 187.912 µM -0.177959579052899 0.445880944984054 no 1886 0.429377360102749 2700 20612
SGTC_1961 st076550 68.7 µM -0.178202010699349 0.445785154877697 no 1887 0.429282165344487 2846 1579337
SGTC_3147 9097027 49.47 µM -0.178243662676868 0.445768697578389 no 1888 0.429265810426868 2753 25236841
SGTC_2757 clomiphene 4.22 µM -0.178665354496744 0.445602086302048 no 1889 0.429100237256126 2888 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_984 1492-0255 2.91 µM -0.178910658288675 0.445505170703783 no 1890 0.429003926857145 2856 1585198
SGTC_1261 0712-0010 12.7 µM -0.179177735051455 0.445399656656567 no 1891 0.428899072829515 2833 2840123
SGTC_2050 5263056 171 µM -0.179528222774252 0.445261195300981 no 1892 0.428761479369625 2848 763468 YGL055W OLE1
SGTC_296 1222-0039 74.9 µM -0.179873702461219 0.445124718921521 no 1893 0.428625860422701 2752 5984176
SGTC_75 0159-0059 199.013 µM -0.181125132676902 0.444630415433572 no 1894 0.428134678913213 3021 5377270
SGTC_1064 honokiol 6.76 µM -0.181438481451935 0.444506658981656 no 1895 0.428011708131088 2804 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.181702705270982 0.444402308533264 no 1896 0.427908021408821 2764 115019
SGTC_2176 5809774 33.9695 µM -0.183400716593633 0.443731801745111 no 1897 0.42724180682128 2859 2870539
SGTC_739 1486-1183 203 µM -0.18340127674708 0.44373158057948 no 1898 0.427241587079251 2784 4346692
SGTC_368 fentichlor 4.58 µM -0.183440103947794 0.443716250461496 no 1899 0.427226355650986 2810 7329 A pesticide.
SGTC_2994 9053520 71.4286 µM -0.183882535292817 0.443541571539663 no 1900 0.427052802999753 2866 4647384
SGTC_2891 9063876 19.48 µM -0.186534868470886 0.442494619446505 no 1901 0.426012668793509 2824 6472478
SGTC_1048 3161-0300 24.5 µM -0.186807505126246 0.442387024558713 no 1902 0.425905781133788 2732 2165101
SGTC_3009 9080819 71.4286 µM -0.191624447458769 0.440486746881688 no 1903 0.424018195542111 2812 17027216
SGTC_606 k015-0008 38.6 µM -0.19240763595458 0.440177908319866 no 1904 0.423711455762586 2874 1970475
SGTC_2376 9072922 81.32 µM -0.193029718971351 0.439932625196142 no 1905 0.423467846695036 2868 17087968
SGTC_685 1278-0033 54.9 µM -0.193462161459385 0.439762129626612 no 1906 0.423298518501642 2865 3590572
SGTC_3262 9137218 49.47 µM -0.193543581251618 0.439730030158498 no 1907 0.423266639160809 2691 17650664
SGTC_1297 1068-0111 14.1 µM -0.194144517118389 0.439493125563955 no 1908 0.423031362544501 2732 767057
SGTC_2900 5328528 85.29 µM -0.194470194759881 0.439364743989989 no 1909 0.422903865669993 2739 795359
SGTC_1188 1403-0014 4.57 µM -0.195546680032663 0.438940440769836 no 1910 0.422482498786639 2784 9614867
SGTC_433 pimozide 108 µM -0.195555229323172 0.438937071295115 no 1911 0.422479152706086 2720 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1417 3966-0327 90.4 µM -0.198236287316338 0.437880623347385 no 1912 0.421430098817722 2790 651118
SGTC_2178 5812956 200 µM -0.198274237706415 0.437865672480367 no 1913 0.421415253438183 2685 5403383
SGTC_253 dyclonine 31.25 µM -0.198864948545742 0.437632968555231 no 1914 0.421184194427526 2748 3180 An oral anasthetic.
SGTC_1626 st003712 1.76 µM -0.198991877621631 0.437582969078687 no 1915 0.421134549129566 2907 24207035
SGTC_3309 9129340 25.759 µM -0.199619398977719 0.437335792626396 no 1916 0.420889127471062 2804 17158987
SGTC_275 trichlorophene 5.69 µM -0.200141688960722 0.437130084749505 no 1917 0.420684884913216 2850 62616
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.201045973260794 0.436773965727587 no 1918 0.420331313213176 2863 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2961 9083290 32.55 µM -0.201495263503242 0.436597048367942 no 1919 0.420155666331339 2791 17741490
SGTC_1176 0848-0131 83.3 µM -0.201891794974666 0.436440916403683 no 1920 0.42000065833085 2873 6769040
SGTC_2992 9074591 71.4286 µM -0.202199666299147 0.436319700684746 no 1921 0.419880316998366 2822 17741321
SGTC_3086 9117350 49.47 µM -0.203465672809104 0.435821309027212 no 1922 0.419385536809187 2759 2679265
SGTC_488 nitrendipine 139 µM -0.203911954532179 0.435645644539878 no 1923 0.41921115149311 2736 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2070 5230947 200 µM -0.204159955445861 0.435548032420039 no 1924 0.419114251586101 2854 2835538
SGTC_1989 st071868 50.2 µM -0.204198991151673 0.435532668487422 no 1925 0.419098999846039 2913 16414057
SGTC_809 3998-0021 90 µM -0.204389400577656 0.435457727275 no 1926 0.419024606237348 2902 715485
SGTC_189 3970-0742 2.116 µM -0.205534240727398 0.435007190824906 no 1927 0.418577374432379 2788 2891807
SGTC_1790 st045711 43.5 µM -0.20558319138864 0.434987928826956 no 1928 0.41855825419828 2915 585119
SGTC_1943 st076331 65.2 µM -0.205623134072579 0.434972211566328 no 1929 0.418542652642146 2856 24208415
SGTC_794 k038-0031 316 µM -0.205847563521648 0.434883901531751 no 1930 0.418454993198551 2759 6624242
SGTC_566 0958-0068 16.5 µM -0.20601570638919 0.434817741654436 no 1931 0.418389321270032 2933 6815365
SGTC_1353 1498-1206 8.11 µM -0.206602662819677 0.434586803770303 no 1932 0.418160090252265 2762 6756808
SGTC_1548 st061468 90.8 µM -0.206915839409071 0.434463593632743 no 1933 0.418037793072343 2893 390799
SGTC_1888 azatryptophan 97.5 µM -0.207727836350381 0.434144166943723 no 1934 0.417720740741566 2875 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3317 9138495 8.753 µM -0.209152884259109 0.433583679813655 no 1935 0.417164445921156 2783 17020139
SGTC_1021 4476-0760 85.3 µM -0.209209440128456 0.433561438511238 no 1936 0.417142371664443 2794 746768
SGTC_2904 7225135 42.03 µM -0.209303976664161 0.433524261306911 no 1937 0.417105473800471 2859 4446116
SGTC_2557 derrustone 83.84 µM -0.20932782610114 0.433514882429178 no 1938 0.417096165416431 2889 629853 An antioxidant.
SGTC_3247 9135149 49.47 µM -0.209391938687888 0.433489670107138 no 1939 0.417071142641879 2753 8934436 YOR116C RPO31
SGTC_2934 9036370 36.88 µM -0.209545841622316 0.433429148769476 no 1940 0.417011076581333 2881 6462800
SGTC_1453 4237-0541 195 µM -0.20972228271152 0.433359766368342 no 1941 0.416942216592621 2876 739892
SGTC_613 3914-0030 117 µM -0.209992537886947 0.433253497186119 no 1942 0.416836748548848 2728 1145395
SGTC_1653 st012112 65 µM -0.210781358126444 0.432943346547288 no 1943 0.416528942901215 2937 720429
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.212617350638894 0.432221625921855 no 1944 0.415812718507217 3201 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3355 9151058 44.0485 µM -0.212756401675319 0.432166974748649 no 1945 0.415758485774726 2755 17015728
SGTC_2986 9022445 71.43 µM -0.212979255833539 0.432079389175489 no 1946 0.415671571466786 2995 6459286
SGTC_170 4197-0004 226 µM -0.213066523155933 0.432045092504191 no 1947 0.415637537870268 2930 218692
SGTC_2315 7733312 200 µM -0.213437207950756 0.431899416484311 no 1948 0.415492980656229 2808 726316
SGTC_459 nigericin 15.3 µM -0.214494703508448 0.431483880540719 no 1949 0.415080648422319 2897 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1011 4112-3381 17.4 µM -0.214872543163378 0.431335429285578 no 1950 0.414933346136072 2954 2877139
SGTC_2012 4023501 200 µM -0.214922407858958 0.431315838427406 no 1951 0.414913907079781 2870 3477460
SGTC_586 0957-0265 8.15 µM -0.21938734713167 0.429562342170218 no 1952 0.41317416274499 2834 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1929 genistein trimethyl ether 50.5 µM -0.219420670237443 0.429549260509499 no 1953 0.413161184903133 2958 136420
SGTC_55 0767-0285 6.563 µM -0.2196162341234 0.429472489501108 no 1954 0.413085023531646 2915 3116166
SGTC_3298 9116858 71.43 µM -0.219708126821943 0.429436416813159 no 1955 0.413049237511949 2936 2506942
SGTC_2154 5570129 200 µM -0.220570400556855 0.429097958039836 no 1956 0.412713475178833 2773 673366
SGTC_602 3130-1533 38.1 µM -0.220846915461097 0.428989431728058 no 1957 0.412605816048991 2915 720941
SGTC_523 1934-0222 13.7 µM -0.220902034688143 0.42896779922664 no 1958 0.412584356551876 2808 1361595
SGTC_2918 7977171 22.06 µM -0.221475320384933 0.42874281592401 no 1959 0.412361175478786 2754 2236483
SGTC_326 k292-0812 17.5 µM -0.222035102179885 0.428523154505025 no 1960 0.412143278838454 2861 3579357
SGTC_1105 epirubicin 18.1 µM -0.222055228840965 0.428515257105769 no 1961 0.412135444982897 2789 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1971 st069429 63.5 µM -0.222942146599426 0.428167272378248 no 1962 0.41179026676341 2944 1246522 YGL099W LSG1
SGTC_2335 9018011 154.17 µM -0.22541624421851 0.427196849119829 no 1963 0.410827737875707 2906 6458208
SGTC_3071 9117417 49.47 µM -0.227887504300348 0.42622797843116 no 1964 0.409866848639461 2885 45595590 YGL055W OLE1
SGTC_1951 sophoraflavanone G 9.2 µM -0.228294836812481 0.426068324120247 no 1965 0.409708519107847 2791 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_761 k216-0224 480 µM -0.229478929386577 0.425604286968131 no 1966 0.409248347809085 2988 1340404
SGTC_536 3852-0578 10.6 µM -0.229637812298153 0.425542029751423 no 1967 0.40918661099172 2977 2869208
SGTC_774 k060-0086 136 µM -0.229964373524638 0.425414074727883 no 1968 0.409059726818775 2800 5911235
SGTC_414 piperonyl butoxide 100 µM -0.230550927668209 0.425184267577982 no 1969 0.408831847282279 2811 5794 A potent inhibitor of cytochrome P450.
SGTC_1669 st015249 58.4 µM -0.234293003053229 0.423718754412302 no 1970 0.4073787587649 2904 722793
SGTC_928 2764-0428 58.7 µM -0.234697108056649 0.42356055704272 no 1971 0.407221916244297 2942 662578
SGTC_2823 7987624 58.44 µM -0.235541665206559 0.423229973082903 no 1972 0.406894172091266 3034 2239440
SGTC_1529 apigenin 74 µM -0.23593656148268 0.423075417849756 no 1973 0.406740948515512 3061 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2524 avocatin b 10.57 µM -0.237475170307214 0.422473347417213 no 1974 0.406144089776903 2934 6710748
SGTC_1183 1254-0324 198 µM -0.238307663640864 0.422147661255941 no 1975 0.405821238914395 2968 5799357
SGTC_1793 st048256 72.231 µM -0.238387136951979 0.422116572666518 no 1976 0.405790421560145 2801 672022
SGTC_2190 6049624 200 µM -0.238709866901442 0.421990331261758 no 1977 0.405665282616072 2858 2265554
SGTC_3292 9120825 59.784 µM -0.238887424659039 0.421920879889248 no 1978 0.40559643848221 2944 24824900
SGTC_349 k015-0014 24 µM -0.240088243994468 0.421451245583085 no 1979 0.40513092382601 2801 2196908
SGTC_2031 5180455 200 µM -0.240478654480894 0.421298582069309 no 1980 0.404979604536008 2828 29949
SGTC_1867 st057372 64 µM -0.241546825906817 0.420880951967796 no 1981 0.404565664397932 2831 688837
SGTC_621 3584-0052 32.1 µM -0.242461504953573 0.420523404538045 no 1982 0.40421129082017 2901 2273927
SGTC_1314 1222-0010 41.1 µM -0.244465322275967 0.419740343216643 no 1983 0.403435228059485 2876 3526027
SGTC_3256 9138902 49.47 µM -0.247367170143676 0.418606909125066 no 1984 0.402312039614214 2833 17228773
SGTC_216 k038-0035 28.382 µM -0.247988155813889 0.418364445458271 no 1985 0.402071785458377 2912 4444231 YPR107C YTH1
SGTC_91 0417-1751 58.384 µM -0.248660309354716 0.41810203826931 no 1986 0.401811776578271 2810 6795624
SGTC_1363 1636-0063 10.4 µM -0.248779110587974 0.418055662329846 no 1987 0.401765825261408 2854 6072185
SGTC_1497 4476-2978 41.3 µM -0.249659561826365 0.417711999823157 no 1988 0.401425316503944 2930 1528379
SGTC_594 1487-1584 10.8 µM -0.249708847137748 0.417692764367573 no 1989 0.401406257941765 2864 5013332
SGTC_2943 9068529 45.32 µM -0.252031844362502 0.416786351067135 no 1990 0.400508224930053 2811 3270634
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.253089813539928 0.416373686966961 no 1991 0.400099405152971 3022 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_976 1348-1067 47.6 µM -0.253216493915188 0.416324281070013 no 1992 0.400050460731901 2879 5310671 YGL099W LSG1
SGTC_557 1315-0110 16.2 µM -0.25353987453757 0.41619816721841 no 1993 0.399925526027313 2847 6833801
SGTC_431 k089-0097 107 µM -0.253592638970778 0.416177590656938 no 1994 0.399905142014792 2971 5499420
SGTC_2639 lactacystin 53 µM -0.253719517320971 0.416128112810095 no 1995 0.399856127350819 2999 3870 A proteasome inhibitor.
SGTC_2471 5466956 24.79 µM -0.25413314198674 0.415966823777842 no 1996 0.399696350025703 2864 724419
SGTC_2293 7624732 200 µM -0.254955915534181 0.41564603310428 no 1997 0.399378574261614 2812 894453
SGTC_2352 9027995 87.8 µM -0.255048824444481 0.415609812434199 no 1998 0.399342694696514 2913 2997347
SGTC_699 0375-0592 111 µM -0.256095163175107 0.415201945377438 no 1999 0.398938678354126 2948 762578
SGTC_2965 9082772 38.63 µM -0.25665217861371 0.414984855751017 no 2000 0.398723645531013 3029 16459634
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.257660522698224 0.414591932638841 no 2001 0.398334457935924 2926 688761
SGTC_1221 2958-7315 257 µM -0.258405262970443 0.414301783296451 no 2002 0.398047077618015 2944 4562705
SGTC_1278 0874-0585 172 µM -0.260691787344897 0.413411250742678 no 2003 0.397165099939066 2930 766306
SGTC_2887 9044784 58.44 µM -0.261227115672438 0.413202820597392 no 2004 0.396958684301734 2874 6465546
SGTC_46 0329-0187a 2.197 µM -0.26232247079981 0.412776420245311 no 2005 0.396536419628182 2958 46494817
SGTC_1873 rapamycin 2 nM -0.26236708360863 0.412759055527877 no 2006 0.396519223743599 2873 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2915 7971052 15.16 µM -0.264864518990348 0.41178724786233 no 2007 0.395556916079557 2891 5741558
SGTC_1122 capsaicin 818.572 nM -0.264915877831204 0.411767268649779 no 2008 0.395537133234553 3006 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2694 st077685 81.9 µM -0.265153504301013 0.411674832046745 no 2009 0.395445605708604 2837 2838096
SGTC_331 k048-0133 24.5 µM -0.268157658798724 0.410506641489899 no 2010 0.394288982559707 2873 6813582
SGTC_3233 9132340 49.47 µM -0.268361533819464 0.410427391623541 no 2011 0.394210522710227 2898 17682950
SGTC_2913 7966556 36.57 µM -0.269804989515974 0.409866399377244 no 2012 0.393655142028116 2989 2976516
SGTC_655 k060-0012 42 µM -0.270949581830667 0.409421690033344 no 2013 0.393214905003824 2886 5994525
SGTC_792 4534-1957 155 µM -0.271860935792948 0.409067684268193 no 2014 0.392864474506209 2929 1717904
SGTC_187 1488-2104 32.728 µM -0.273233512541797 0.408534661438711 no 2015 0.392336860224189 2945 2852859
SGTC_1049 3226-0134 66 µM -0.273876362945016 0.408285076715493 no 2016 0.392089818476421 2902 5702385
SGTC_2394 5221648 200 µM -0.274744202060672 0.407948199832952 no 2017 0.391756384551656 3018 788586
SGTC_180 1486-1293 102.781 µM -0.275211656873709 0.407766771889951 no 2018 0.391576815878506 2991 4140536
SGTC_451 chloral hydrate 100 µM -0.276628211058636 0.407217101685861 no 2019 0.391032800206218 3013 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2759 disulfiram 3.38 µM -0.276799444400514 0.407150669799865 no 2020 0.390967053906387 2900 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_109 0132-0036 33.701 µM -0.276858348605576 0.407127817873449 no 2021 0.390944437924284 2848 67274 A color developer.
SGTC_2260 7964312 200 µM -0.277056291171169 0.407051028237059 no 2022 0.39086844154466 3059 231951
SGTC_1710 st031758 61.5 µM -0.27823081015711 0.40659546013377 no 2023 0.390417592571567 3045 5394341
SGTC_2351 9026858 72.31 µM -0.279166403327509 0.406232656101647 no 2024 0.390058562657382 2867 1409300
SGTC_1620 st003704 16.5 µM -0.279927595771842 0.405937540500923 no 2025 0.389766527443221 2901 2834414
SGTC_168 3970-0862 530.542 µM -0.280562141277706 0.405691566970718 no 2026 0.389523128494355 2991 3135186
SGTC_1606 st000094 49.2 µM -0.280884644603404 0.405566566904563 no 2027 0.389399439278031 3041 1242210
SGTC_2687 chenodiol 100 µM -0.282450823555955 0.404959663895715 no 2028 0.388798924554401 2995 5702181 A cholesterol synthesis inhibitor.
SGTC_1944 st076371 56.9 µM -0.285683162159017 0.403707838826014 no 2029 0.387560401060579 2898 24208455
SGTC_1994 st072947 40.9 µM -0.2869010576594 0.403236425362014 no 2030 0.387094040312346 3023 5286565 YDL195W SEC31
SGTC_2426 5582046 32.21 µM -0.288783509241914 0.402508057535268 no 2031 0.386373526215315 3104 2251934
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.288815811699052 0.402495561848056 no 2032 0.386361165761788 2924 5106787 A p450 inhibitor.
SGTC_2998 9066762 71.4286 µM -0.288920556437761 0.402455043711961 no 2033 0.386321086245705 3094 4945196
SGTC_2564 betulinic acid 100 µM -0.289677505746311 0.402162266145329 no 2034 0.386031483318616 3205 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1426 4048-4480 71.7 µM -0.290159637243375 0.401975812924208 no 2035 0.385847056643212 3026 14224343
SGTC_1470 k295-0292 231 µM -0.290685177860689 0.401772597638847 no 2036 0.385646054343593 3016 5045612
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.292117113691956 0.401219033672142 no 2037 0.385098541121859 2945 368090
SGTC_572 0960-0087 17.7 µM -0.294047245033406 0.400473188974878 no 2038 0.384360900993204 2957 6796365
SGTC_2433 5607874 27.82 µM -0.294954660847659 0.400122668978419 no 2039 0.384014257510299 2922 2252428
SGTC_369 0957-0393 4.5 µM -0.296694141301204 0.399450961058932 no 2040 0.383350015157976 2988 6997992
SGTC_1128 3448-9350 235 µM -0.297379203666736 0.399186502807044 no 2041 0.383088509495982 3009 619386
SGTC_1841 st054148 70 µM -0.297666871092664 0.399075466812155 no 2042 0.382978715425298 3019 675442
SGTC_3144 9087057 49.47 µM -0.29780919317645 0.399020535303258 no 2043 0.382924398809346 3047 17249618
SGTC_352 k048-0007 5.11 µM -0.299334787508578 0.398431833328187 no 2044 0.382342307047992 3024 6811911
SGTC_1558 st069300 45.6 µM -0.300207649247205 0.398095114052739 no 2045 0.382009385385506 3047 24208000
SGTC_896 0964-0007 44.5 µM -0.300284391514515 0.398065513217802 no 2046 0.381980118980835 3049 6756758
SGTC_5 0352-0601 109.883 µM -0.30142259112747 0.397626558682593 no 2047 0.38154613483105 2992 762456
SGTC_747 3448-8087 38.7 µM -0.303671978225538 0.39675944863379 no 2048 0.380688904280608 2989 5168703
SGTC_2307 7538926 6.34 µM -0.303678841216459 0.3967568038169 no 2049 0.380686289721635 2974 96582
SGTC_3152 9099253 49.47 µM -0.304100999031024 0.396594124391744 no 2050 0.380525472873121 3011 25236131
SGTC_1487 3970-0795 2.82 µM -0.304536193538839 0.396426440089097 no 2051 0.380359711435629 3039 3765103
SGTC_439 amiodarone 34.4 µM -0.305391665230502 0.396096875126817 no 2052 0.380033934486197 2975 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3171 9103192 49.47 µM -0.305529891741854 0.39604363121465 no 2053 0.379981303657307 3029 13018434
SGTC_2040 5100729 123 µM -0.306203245238237 0.39578428777837 no 2054 0.379724950832574 2938 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.306544666362091 0.3956528063726 no 2055 0.379594988371908 3126 688798
SGTC_351 caspofungin 25 nM -0.308250734413127 0.394995977108605 no 2056 0.378945775086072 2979 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2990 9074105 71.4286 µM -0.308566768125862 0.394874338104074 no 2057 0.378825551602015 3023 6502001
SGTC_3313 9133968 57.047 µM -0.308731672843201 0.394810871583116 no 2058 0.378762824278682 2900 1494643
SGTC_2101 5377231 179.231 µM -0.308893664471543 0.394748528934164 no 2059 0.378701208160776 3093 2844213
SGTC_1787 fluconazole 80 µM -0.311300400037258 0.393822612508928 no 2060 0.377786131599619 3033 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3089 9117425 49.47 µM -0.312647638618427 0.393304566059143 no 2061 0.3772741903942 3012 9401657
SGTC_755 1995-0008 37.3 µM -0.313078323813495 0.393138996775538 no 2062 0.377110578478696 3057 689533
SGTC_744 1594-0068 283 µM -0.314372746679555 0.392641495315118 no 2063 0.376618976324525 2979 668392
SGTC_1436 4092-1007 8.32 µM -0.31526871474833 0.392297239535814 no 2064 0.376278818341641 2974 2881121
SGTC_2916 7875993 68.79 µM -0.315318292657805 0.392278192786234 no 2065 0.376259998686103 3023 1299250
SGTC_1711 st032263 62.8 µM -0.315582110296945 0.392176844154868 no 2066 0.37615985909206 3011 3958979
SGTC_2610 ononetin 44.17 µM -0.315590656047203 0.392173561327227 no 2067 0.376156615445437 3017 259632
SGTC_2569 tetrandrine 100 µM -0.315661642061682 0.392146292531835 no 2068 0.376129672152061 3006 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2140 5586273 200 µM -0.315715417936201 0.39212563524744 no 2069 0.376109261502942 2966 854421
SGTC_194 1486-1323 56.904 µM -0.316431537852364 0.3918505763439 no 2070 0.375837491030303 3007 5178754
SGTC_1303 1160-0052 261 µM -0.316594118743152 0.391788137172621 no 2071 0.375775799481573 2983 3562476
SGTC_852 0418-0143 439 µM -0.316668292598594 0.391759651638252 no 2072 0.375747655162026 3067 5369229
SGTC_426 0988-0037 14.6 µM -0.318028420128802 0.391237414828492 no 2073 0.37523168953221 3170 5383008
SGTC_1137 ixabepilone 100 µM -0.318119337234302 0.391202513125759 no 2074 0.375197207991356 2930 154225 A novel microtubule stabilizer.
SGTC_1485 3909-9022 254 µM -0.318342622515234 0.391116800999367 no 2075 0.375112528263945 3013 714516
SGTC_155 k072-0202 43.6 µM -0.319175121182313 0.390797277850318 no 2076 0.374796860761427 2976 5857737
SGTC_2292 7671323 168.05 µM -0.32022333929079 0.390395063810553 no 2077 0.374399515893406 3130 937504
SGTC_117 lucigenin 22.078 µM -0.320949226636911 0.390116600704746 no 2078 0.374124434096472 3045 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2017 5132927 60.65 µM -0.321003784361128 0.390095673681748 no 2079 0.374103761524229 2983 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1644 st010134 20.9 µM -0.321246484525328 0.390002583631598 no 2080 0.374011803926377 3084 3818134
SGTC_223 busulfan 5 mM -0.322169131386688 0.38964875091186 no 2081 0.373662284186401 3057 2478 A DNA alkylator.
SGTC_945 3381-0768 11.3 µM -0.322294619885443 0.389600633450548 no 2082 0.37361475429117 3121 1126236 YIL048W NEO1
SGTC_2968 9090663 33.37 µM -0.3223321741582 0.38958623392387 no 2083 0.373600530646975 3028 25236811
SGTC_3099 9120367 49.47 µM -0.323321805191259 0.389206831959082 no 2084 0.373225770963157 2958 24824940
SGTC_332 4112-0506 40.9 µM -0.32462382317255 0.3887078288808 no 2085 0.372732897317379 2973 2790355
SGTC_202 3594-0513 34.79 µM -0.325101591996755 0.388524768256234 no 2086 0.372552092055105 2983 708429
SGTC_121 0557-0495 61.343 µM -0.325295059574796 0.388450646776358 no 2087 0.372478884807069 2988 3104427
SGTC_1228 0124-0032 52.5 µM -0.325502703421172 0.388371098590573 no 2088 0.372400318449726 3057 X1228
SGTC_105 0111-0055 734.78 µM -0.326030192116344 0.388169039169917 no 2089 0.372200756043345 3061 5179370
SGTC_2512 diallyl trisulfide 49.23 µM -0.326757965291247 0.387890308625978 no 2090 0.371925477264211 3030 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1690 st023502 41.2 µM -0.327982467929882 0.387421465587243 no 2091 0.371462459318527 3070 24207482
SGTC_347 4534-1311 26.2 µM -0.328628672229664 0.387174110122251 no 2092 0.371218186701397 2939 2862016
SGTC_2886 9058944 51.95 µM -0.329641901026532 0.386786356488305 no 2093 0.370835279085003 3023 4949929
SGTC_3307 9126885 69.2785 µM -0.334424728185985 0.384957542592052 no 2094 0.36902954106179 2986 24824909
SGTC_114 0364-0001 490.298 µM -0.334534200940272 0.384915713168879 no 2095 0.368988243688004 3044 4003655
SGTC_836 0330-0104 1.35 µM -0.336146051774046 0.38429998195897 no 2096 0.368380366265176 3009 46494820
SGTC_750 4073-0104 132 µM -0.336590023754734 0.38413043470566 no 2097 0.368212988858145 3052 22330957
SGTC_1677 st019204 53.9 µM -0.338143727715531 0.383537269674578 no 2098 0.367627439673164 3092 3945625
SGTC_470 aa-861 153 µM -0.338660214092352 0.383340148543756 no 2099 0.367432857915571 3021 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1696 st025591 34.7925 µM -0.339255254284452 0.38311308416259 no 2100 0.367208723882694 3004 2787147
SGTC_25 0118-0223 35.662 µM -0.339335612896724 0.38308242279121 no 2101 0.367178458637168 3148 5333628
SGTC_2095 5432005 200 µM -0.339944840330002 0.38284999178855 no 2102 0.366949033824311 3004 783734
SGTC_1927 st060202 13.8 µM -0.340242539352551 0.382736429701453 no 2103 0.366836942650809 3077 688887
SGTC_2712 st079126 47.7 µM -0.340815768302767 0.38251779068724 no 2104 0.366621139510777 2993 3152970
SGTC_2334 9017922 200 µM -0.341676317878493 0.382189633144678 no 2105 0.366297248123461 3132 3163164
SGTC_3 0833-0587 95.581 µM -0.341736540580956 0.382166671294482 no 2106 0.366274585223526 3059 5382644
SGTC_1219 1469-0211 33.1 µM -0.341806511912357 0.382139992985151 no 2107 0.366248254322715 3129 6822282
SGTC_1984 st072354 53.1 µM -0.343933031933553 0.381329471842341 no 2108 0.365448324829727 2968 5762938
SGTC_2780 5215298 71.43 µM -0.345577561070407 0.38070301758247 no 2109 0.364830105903985 3152 2834131
SGTC_1032 k061-1018 98.7 µM -0.345660962552761 0.380671255580692 no 2110 0.364798762582528 3204 4005393
SGTC_3314 9135860 59.4275 µM -0.348038925847616 0.379765988830874 no 2111 0.363905475098685 3173 25252478
SGTC_3079 9117512 49.47 µM -0.348560457242122 0.379567534946762 no 2112 0.363709659265226 3050 7185044
SGTC_909 3448-9333 149 µM -0.348587194675006 0.379557361634347 no 2113 0.363699621302531 3002 3344074
SGTC_2372 9071633 200 µM -0.351270130807252 0.378536957676649 no 2114 0.362692850548266 3156 21321366
SGTC_1621 st003705 32.4 µM -0.352933644197357 0.377904696423397 no 2115 0.362069093690775 3175 24207032
SGTC_962 1254-0300 21.5 µM -0.354598563936738 0.37727222795763 no 2116 0.361445176074636 2977 7340576
SGTC_885 0865-0106 16.8 µM -0.355038529335419 0.377105149128003 no 2117 0.36128036341319 3020 2793380
SGTC_3216 9129716 49.47 µM -0.355619298304739 0.37688463474434 no 2118 0.36106284463776 3031 8056934
SGTC_213 1246-0773 967 nM -0.35701803460663 0.376353708165247 no 2119 0.360539152302169 3076 6251622
SGTC_1199 1638-0010 4.46 µM -0.357093489421296 0.376325073976012 no 2120 0.360510909149245 3023 3111136
SGTC_3081 9117243 49.47 µM -0.357194567458733 0.376286717150392 no 2121 0.360473076275355 3197 45595589
SGTC_1716 st033144 30.6155 µM -0.357396500354898 0.376210091849376 no 2122 0.360397498152503 3197 674617
SGTC_2974 9094440 9.66 µM -0.357870172972186 0.376030371554082 no 2123 0.360220236472456 3204 25236134
SGTC_127 0180-0333 59.125 µM -0.35795144278621 0.37599953895976 no 2124 0.360189826030046 3065 771601
SGTC_2086 5274770 176.623 µM -0.35816002942785 0.375920407822189 no 2125 0.360111778811267 3103 689278
SGTC_1820 st053765 18.6 µM -0.358638189788161 0.375739028683447 no 2126 0.359932886742597 3102 3690829
SGTC_995 3931-2021 34.6 µM -0.35974084486631 0.37532086654805 no 2127 0.359520472154212 3138 730143
SGTC_3042 9091578 49.47 µM -0.35979306530608 0.375301066512707 no 2128 0.35950094474029 3110 25236497
SGTC_197 4544-0043 41.561 µM -0.359897220084901 0.375261575901829 no 2129 0.359461997993204 3024 896523
SGTC_3228 9131799 49.47 µM -0.360419196966511 0.375063686431254 no 2130 0.359266836421538 3103 17015818
SGTC_2650 prasterone 100 µM -0.360820374088547 0.374911616354287 no 2131 0.359116865536318 3101 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1076 itraconazole 331 nM -0.36156579810524 0.374629107805117 no 2132 0.358838263483308 3087 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2866 9034245 58.44 µM -0.362762166187182 0.374175836477044 no 2133 0.358391278192331 3089 6462273
SGTC_1501 4491-0275 38.4 µM -0.363033595527165 0.374073023460879 no 2134 0.358289894132718 3150 5104718
SGTC_1826 st055655 41.6 µM -0.363471284733763 0.373907252782939 no 2135 0.35812642987213 3119 676168
SGTC_3061 glucosamine 200 µM -0.365154134884805 0.37327010652505 no 2136 0.357498176437991 3146 91431 and experimental redox chemotherapeutic
SGTC_1018 4259-0013 28.1 µM -0.366030788669512 0.372938332503681 no 2137 0.357171050686815 3179 6801262
SGTC_214 4373-3496 70 µM -0.366749805247348 0.372666287388271 no 2138 0.356902826020213 3104 3779166
SGTC_1257 0669-0121 16 µM -0.367425913448873 0.372410534896279 no 2139 0.356650672571227 3114 4307855
SGTC_1386 3228-0095 33.8 µM -0.368176863143705 0.372126537941295 no 2140 0.356370680529284 3172 870181
SGTC_1496 4469-0713 57.4 µM -0.369977561956045 0.371445826525275 no 2141 0.355699604489717 3168 746691
SGTC_1882 5615643 20 µM -0.369985852900783 0.371442693258346 no 2142 0.355696515691284 3130 2253075
SGTC_1795 st049545 62.3 µM -0.370087680162716 0.371404211970448 no 2143 0.355658580632084 3173 5291882
SGTC_411 enrofloxacin 100 µM -0.371396981074866 0.370909531950557 no 2144 0.355170936897949 3228 71188 A bacterial gyrase inhibitor.
SGTC_2187 6125751 200 µM -0.372221977438888 0.370597941330322 no 2145 0.354863792104284 3093 874498
SGTC_1755 st041960 45.185 µM -0.373159482996289 0.370243960437601 no 2146 0.354514874804489 3176 2257073
SGTC_2659 sanguinarine 24.21 µM -0.375064452047639 0.369525025915257 no 2147 0.353806266794699 3041 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1591 genipin 88.4 µM -0.375184560412469 0.369479712323145 no 2148 0.353761605973045 3185 442424 A DNA cross-linking agent.
SGTC_1275 0867-0008 21.1 µM -0.375925182473033 0.369200336009902 no 2149 0.353486259234221 3024 3422836
SGTC_570 0987-0065 62.6 µM -0.376589938644773 0.368949636526347 no 2150 0.353239183009919 3028 3104428
SGTC_2342 7990637 118.86 µM -0.37781990740289 0.368485925489181 no 2151 0.352782192015931 3175 2033102 YER133W GLC7
SGTC_1075 aripiprazole 15.2 µM -0.382043890052749 0.366894901604511 no 2152 0.35121440489855 3061 60795 An atypical antipschotic. YIL048W NEO1
SGTC_377 3970-0964 33.1 µM -0.382885605255889 0.366578129462885 no 2153 0.350902292455127 3073 16481235
SGTC_1889 st059080 5.18 µM -0.38344532446977 0.366367534326296 no 2154 0.350694801277122 3245 176925 Isolated from Daphnopsis sellowiana.
SGTC_525 k781-2675 26.7 µM -0.384271917586284 0.366056601112202 no 2155 0.350388459837201 3174 3651118 YDL195W SEC31
SGTC_2167 5876490 200 µM -0.384300421798136 0.366045880468144 no 2156 0.350377897702609 3250 686534
SGTC_2843 9000894 45.46 µM -0.386252841546506 0.36531181033391 no 2157 0.349654711255331 3135 2242070
SGTC_1759 st043059 70 µM -0.386895293776496 0.365070369062232 no 2158 0.349416862697128 3058 669426
SGTC_630 4356-0227 183 µM -0.387706482575997 0.364765590964673 no 2159 0.349116628964544 3149 779312
SGTC_825 1988-2224 89.6 µM -0.388572052033571 0.364440475310786 no 2160 0.348796372214605 3084 1180859
SGTC_2379 9035213 200 µM -0.389512921818382 0.364087186768787 no 2161 0.34844837685069 3240 646551
SGTC_1420 4'-methoxyflavone 42 µM -0.389526304964084 0.364082162344505 no 2162 0.348443427804673 3173 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2207 7258803 200 µM -0.39036050441575 0.363769025620962 no 2163 0.348134994373679 3166 3666799
SGTC_526 4469-0568 170 µM -0.392377566664074 0.363012249305811 no 2164 0.347389629500185 3089 2901964
SGTC_1774 st048371 48.465 µM -0.393154824204374 0.362720774605561 no 2165 0.347102566830408 3064 4242727
SGTC_7 0192-1582 4.227 µM -0.393792901006441 0.362481552674189 no 2166 0.346866972999297 3129 252616
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.394009745766936 0.362400267432414 no 2167 0.346786921990059 3145 77254
SGTC_1561 5-methoxyflavone 52.9 µM -0.394175882315047 0.362337994590565 no 2168 0.346725595191257 3134 94525
SGTC_1809 st050081 57.6 µM -0.39658336121051 0.361436010623111 no 2169 0.345837362171799 3264 5036894
SGTC_2768 sulfasalazine 50.2 µM -0.397359842787359 0.361145258595404 no 2170 0.345551061907386 3254 5384001 An antioxidant and salicylic acid derivative.
SGTC_1196 1588-0294 184 µM -0.398095176205461 0.360869988348874 no 2171 0.345280015002044 3146 6144269
SGTC_2113 5491891 107.031 µM -0.399711099155151 0.360265324917423 no 2172 0.344684658090536 3133 789979
SGTC_3192 9110362 49.47 µM -0.399871859289249 0.360205189043924 no 2173 0.344625449996496 3163 16649480
SGTC_1607 st000305 50.6 µM -0.399987139232316 0.360162068168227 no 2174 0.344582994638577 3235 5457690
SGTC_890 0929-0006 47.2 µM -0.400442254256831 0.359991848143853 no 2175 0.344415403762827 3101 1378169
SGTC_2722 naftopidil 47.16 µM -0.403723891038703 0.35876528907529 no 2176 0.343207884560748 3220 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_652 0437-0092 114 µM -0.403782949389334 0.358743228456719 no 2177 0.343186167916047 3145 3091274
SGTC_3077 9117319 49.47 µM -0.40380750300164 0.358734056854742 no 2178 0.343177139335531 3148 17154678
SGTC_3200 9114385 49.47 µM -0.404634444923062 0.358425213768078 no 2179 0.342873117778678 3242 17018030 YLR208W SEC13
SGTC_3323 9138564 53.9225 µM -0.404732033793041 0.358388772756232 no 2180 0.342837246366713 3263 43912313 YNL103W MET4
SGTC_70 0141-0289 43.283 µM -0.406296808134623 0.357804641053027 no 2181 0.342262265186244 3150 352408
SGTC_1958 st076513 41.9 µM -0.407237932375845 0.357453478701717 no 2182 0.341916622082316 3097 732122 YGL099W LSG1
SGTC_873 0591-4978 488 µM -0.407264630348189 0.357443518627152 no 2183 0.341906818750746 3304 3305145
SGTC_1519 esterone 74 µM -0.408197138095331 0.357095693752679 no 2184 0.341564474552346 3088 698 A steroid.
SGTC_903 1134-0042 114 µM -0.408395540638718 0.357021705022184 no 2185 0.341491653395477 3131 701009
SGTC_128 0906-2981 13.371 µM -0.410083669461604 0.356392381925749 no 2186 0.340872285874505 3279 6740226
SGTC_2419 paclitaxel 166.5 µM -0.410232332020006 0.356336980223197 no 2187 0.340817762707056 3124 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3141 9094609 49.47 µM -0.410450438073827 0.356255704674996 no 2188 0.340737776607109 3058 25236309 YDL196W YDL196W
SGTC_3149 9097855 49.47 µM -0.41060821748652 0.356196913456988 no 2189 0.340679918577947 3247 25236625 YMR079W SEC14
SGTC_1476 4112-3294 3.34 µM -0.411125278620221 0.356004271892022 no 2190 0.340490337491517 3249 704369
SGTC_22 0964-0034 14.468 µM -0.411523340519406 0.355855990931959 no 2191 0.340344415067773 3187 138402
SGTC_707 0865-0008 204 µM -0.412930556526248 0.355331967632511 no 2192 0.339828746402289 3119 723043
SGTC_3269 9137823 49.47 µM -0.414412256857224 0.354780503131863 no 2193 0.339286107033071 3103 17682936
SGTC_2621 lithochol-11-enic acid 100 µM -0.415110613923914 0.354520691505066 no 2194 0.339030464924066 3256 6708711
SGTC_2400 5203494 178.7 µM -0.415691885804809 0.354304490989008 no 2195 0.338817739774103 3174 6777674
SGTC_2762 leflunomide 42.06 µM -0.416747230723509 0.353912081943077 no 2196 0.338431651899595 3132 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2091 4-phenylthiadiazole 200 µM -0.417696831003794 0.353559124515816 no 2197 0.338084394787472 3115 270010
SGTC_1264 0783-0040 158 µM -0.419194870436901 0.353002573457629 no 2198 0.337536860320963 3077 2855798
SGTC_460 trequinsin 123 µM -0.419803060177401 0.352776708675685 no 2199 0.337314664588847 3230 5537 A vasodilator.
SGTC_859 0439-0102 54.6 µM -0.420700800027419 0.35244340784977 no 2200 0.336986788446004 3272 610143
SGTC_641 4092-0595 30 µM -0.421050233802427 0.35231370536947 no 2201 0.336859200305861 3219 786260
SGTC_3146 9095609 49.47 µM -0.42119716052892 0.352259174381467 no 2202 0.336805558813213 3182 17173999
SGTC_2824 7998404 51.95 µM -0.422082592427611 0.351930615893763 no 2203 0.33648236670965 3115 837851
SGTC_244 nsc-207895 1.295 µM -0.423383680915105 0.351448019709539 no 2204 0.336007674674066 3117 42640
SGTC_1824 st053723 68.6 µM -0.423527850025907 0.351394559614436 no 2205 0.335955091769191 3192 675225
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.423532987650208 0.351392654559585 no 2206 0.335953217978975 3069 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_789 1309-1135 70.6 µM -0.424724536731094 0.350950923576636 no 2207 0.335518747368289 3186 3092424
SGTC_1358 1509-0022 2.48 µM -0.425253071336721 0.350755049699665 no 2208 0.335326099886877 3218 3258434
SGTC_1924 st058459 75.1 µM -0.428008388480815 0.349734578010639 no 2209 0.334322506576362 3240 688683
SGTC_779 1360-0071 233 µM -0.42838106420753 0.349596635262686 no 2210 0.334186854305931 3344 7566
SGTC_141 0443-0274 32.331 µM -0.42963658442598 0.349132061363897 no 2211 0.333730010107679 3319 1627241
SGTC_1142 3253-1408 9.78 µM -0.430573634241359 0.348785476720324 no 2212 0.333389207761239 3284 256655
SGTC_481 bay k-8644 50 µM -0.431231858155673 0.348542096233161 no 2213 0.333149895786945 3185 2303 A calcium channel antagonist.
SGTC_1312 1218-2183 165 µM -0.431910820736267 0.348291112861922 no 2214 0.332903114971179 3257 6744073
SGTC_1917 st066507 28.5 µM -0.433072427524054 0.347861870680097 no 2215 0.332481076528555 3122 3156428
SGTC_927 2425-1185 123 µM -0.435848510863353 0.346836830207586 no 2216 0.331473322298827 3117 730375
SGTC_2416 tofa 880 nM -0.437594252286151 0.346192806072852 no 2217 0.330840219245731 3143 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2415 st077333 57.7 µM -0.437761775761605 0.346131028078746 no 2218 0.330779491302782 3389 2766255
SGTC_627 1391-0720 175 µM -0.43892444630748 0.345702380451047 no 2219 0.330358141273115 3232 997839
SGTC_2736 butenafine 14.65 µM -0.440278839506777 0.345203298805701 no 2220 0.329867582344084 3179 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2589 lobaric acid 100 µM -0.440487096018351 0.345126582012611 no 2221 0.329792178109517 3161 73157 A novel microtubule depolymerizer.
SGTC_1072 oxiconazole 14.9 nM -0.441888128350206 0.344610640274263 no 2222 0.329285080874561 3265 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1572 epiandrosterone 68.9 µM -0.442441871730637 0.344406799305752 no 2223 0.329084742485907 3183 441302 A steroid.
SGTC_1399 3562-5772 25 µM -0.443990549948057 0.343836948445671 no 2224 0.328524708111414 3166 23847490
SGTC_134 0269-0018 6.916 µM -0.444090447323589 0.34380020241795 no 2225 0.328488596339695 3217 4378915
SGTC_734 2023-0417 80 µM -0.444821675841899 0.343531273900934 no 2226 0.328224314297368 3256 3935732
SGTC_336 4111-0029 111 µM -0.447427034587929 0.342573729188315 no 2227 0.327283379892543 3210 3131175
SGTC_291 SEC14.278 35.5 µM -0.447808936090459 0.342433454134255 no 2228 0.327145546830146 3305 1068044
SGTC_1008 4106-0037 6 µM -0.448025872342871 0.342353781630802 no 2229 0.327067262300351 3111 2905394
SGTC_409 arachidonic acid 100 µM -0.44980580135615 0.341700346034375 no 2230 0.326425237193984 3202 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2903 5923464 63.88 µM -0.450939673368152 0.34128433359118 no 2231 0.326016514369101 3280 2876576
SGTC_1531 st059297 52.4 µM -0.452597425383576 0.340676459090981 no 2232 0.325419326519072 3293 7566702
SGTC_1293 1000-1278 195 µM -0.453871673815523 0.340209490997971 no 2233 0.324960596220198 3320 678847
SGTC_1136 pergolide 1.05886 µM -0.455889137803233 0.339470661189564 no 2234 0.324234850438518 3157 47811 A dopamine receptor agonist.
SGTC_1078 idebenone 36.1 µM -0.456273329323605 0.339330033487246 no 2235 0.324096720117416 3270 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1184 1269-1718 139 µM -0.456368450931806 0.339295219064834 no 2236 0.324062524303091 3338 5403821
SGTC_1663 st014140 55.4 µM -0.457103283041437 0.339026317429866 no 2237 0.323798405325652 3290 4207120
SGTC_709 3807-1509 243 µM -0.459083683145298 0.338302025992601 no 2238 0.323087036744321 3266 1886677 YPL242C IQG1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.461050440077207 0.337583315932111 no 2239 0.322381208641869 3266 5355888
SGTC_2468 5987765 72.9 µM -0.461672155511842 0.337356246090504 no 2240 0.322158220896146 3235 26772094
SGTC_1243 0416-0003 5.65 µM -0.462398393022284 0.337091076527768 no 2241 0.321897825751901 3205 2141977
SGTC_160 3453-0671 289.699 µM -0.463310425925835 0.336758182524062 no 2242 0.321570936836393 3208 5322268
SGTC_2754 granisetron 64.02 µM -0.463681884697671 0.336622635887257 no 2243 0.321437838929464 3353 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.464807371837097 0.336212071233029 no 2244 0.32103470407933 3330 6708760
SGTC_1777 st045864 34.765 µM -0.465330718205177 0.336021227031428 no 2245 0.320847320008356 3299 4691462
SGTC_1784 st039334 36.3 µM -0.46540971044483 0.33599242528332 no 2246 0.32081904081368 3402 3496984
SGTC_2611 pyromycin 23.93 µM -0.467523226490931 0.335222163873922 no 2247 0.320062789270252 3225 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1919 st067113 52.3 µM -0.468198533023071 0.334976197234213 no 2248 0.319821310572767 3328 1268243
SGTC_1004 4084-0029 199 µM -0.468222385796613 0.334967510640918 no 2249 0.3198127826019 3332 716894 YLR208W SEC13
SGTC_2852 9023854 51.95 µM -0.469519191375163 0.334495378936839 no 2250 0.319349285201608 3370 19798528
SGTC_3036 9090181 49.47 µM -0.470936631902001 0.333979626580511 no 2251 0.318842993830648 3272 25236586
SGTC_2816 7982706 58.44 µM -0.471235777059556 0.333870819126587 no 2252 0.318736186208733 3304 2981853
SGTC_1686 st019653 115.5 µM -0.471285586402759 0.333852703432548 no 2253 0.318718403603727 3338 97252
SGTC_1870 st057514 26.5 µM -0.471517200479581 0.333768470313179 no 2254 0.318635719749263 3191 5393161
SGTC_2222 6885208 172.143 µM -0.472112689921109 0.333551941916834 no 2255 0.318423177573626 3270 609514
SGTC_2451 5856223 45.7 µM -0.472255470607364 0.333500033073597 no 2256 0.31837222514865 3239 2179896
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.472452276919367 0.333428488089648 no 2257 0.318301998880458 3367 1273210
SGTC_3133 9127736 49.47 µM -0.47280326025085 0.333300910184391 no 2258 0.318176773933875 3389 27243420
SGTC_2057 5236571 38.335 µM -0.473034197386618 0.333216978036937 no 2259 0.318094390782947 3379 54684039 YBR257W POP4
SGTC_2348 9022543 33.42 µM -0.475553314885495 0.332301969317035 no 2260 0.317196320888601 3329 3162678 YDL140C RPO21
SGTC_2693 st077581 40.7 µM -0.47559702799615 0.332286100382909 no 2261 0.317180746564505 3342 25238761
SGTC_2773 thioridazine 9.09 µM -0.476798765908759 0.331849957810334 no 2262 0.316752712299714 3325 5452 An antipsychotic.
SGTC_2486 5283202 22.39 µM -0.476953842718399 0.331793692902624 no 2263 0.316697494989141 3247 1377751
SGTC_2490 carminic acid 95.39 µM -0.477327068771708 0.331658294726024 no 2264 0.31656461927221 3332 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2647 atorvastatin 60.16 µM -0.47898392955285 0.331057487898713 no 2265 0.315975030655936 3293 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3000 9075062 71.4286 µM -0.480938838991907 0.330349162523198 no 2266 0.315279983962812 3238 17057871
SGTC_138 0850-0259 40.9225 µM -0.480968687705315 0.33033835209438 no 2267 0.315269376636302 3351 6813004
SGTC_2624 nerol 100 µM -0.481099791217931 0.330290871483837 no 2268 0.315222788231774 3273 637566 A natural product oil.
SGTC_361 000s-0510 1.45 µM -0.481434528249881 0.330169655101546 no 2269 0.315103850788514 3289 660
SGTC_298 1391-0729 10 µM -0.48168536079157 0.330078834247513 no 2270 0.315014738519302 3255 3237558
SGTC_2248 tofa 1.1 µM -0.483164459817151 0.329543489318689 no 2271 0.314489484015278 3172 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2964 9083345 53.42 µM -0.483959586486452 0.329255845480636 no 2272 0.314207275344128 3262 17741579
SGTC_183 3914-0051 30.55 µM -0.484299693074521 0.329132839869936 no 2273 0.314086596869808 3360 1596232
SGTC_2004 4023728 41.89 µM -0.486049118443616 0.328500421505513 no 2274 0.313466170509404 3386 360084 YDR527W RBA50
SGTC_483 fpl-64176 144 µM -0.486214471645591 0.328440671589357 no 2275 0.313407555944771 3349 3423
SGTC_1478 0453-0656 35.7 µM -0.486461550683404 0.328351398447408 no 2276 0.313319979907719 3348 5258496
SGTC_2822 7994718 71.43 µM -0.487032439039988 0.328145165918749 no 2277 0.313117671398463 3284 1018011
SGTC_2732 terfenadine 20 µM -0.48775010674528 0.327885983887102 no 2278 0.312863427768622 3320 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1900 st060200 72.8 µM -0.488117954467863 0.32775316967576 no 2279 0.312733147152633 3235 688945
SGTC_2075 5212009 200 µM -0.488543724098456 0.327599469523138 no 2280 0.312582381541982 3349 780898
SGTC_2658 polymyxin b sulfate 77.05 µM -0.488627984891362 0.327569055369715 no 2281 0.31255254839576 3292 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_978 1416-0512 87.4 µM -0.492203782901937 0.326279418498897 no 2282 0.311287645238714 3346 6814003
SGTC_1423 4048-0112 5.59 µM -0.493904772654628 0.325666671560572 no 2283 0.310686716904481 3351 X1423
SGTC_4 0960-0234 25.671 µM -0.494686111971722 0.325385367644093 no 2284 0.310410853184435 3345 6821112
SGTC_3191 9110352 49.47 µM -0.495499502579219 0.325092630021828 no 2285 0.310123786525965 3346 17122424
SGTC_1151 3909-8316 15.3 µM -0.498219211655667 0.324114596890241 no 2286 0.309164771425623 3369 800431
SGTC_1381 2324-0066 62.1 µM -0.498370268705232 0.324060310830712 no 2287 0.309111544189679 3331 10885928
SGTC_1139 k015-0024 46.9 µM -0.499145621355892 0.323781727721441 no 2288 0.308838400043702 3374 2766652
SGTC_1415 3966-0071 78.1 µM -0.499879498900997 0.323518137471632 no 2289 0.308579964262748 3343 2893185
SGTC_3177 9107506 49.47 µM -0.500130663527319 0.323427945819625 no 2290 0.308491538131342 3345 8897194
SGTC_39 0986-0283 58.349 µM -0.501120943322643 0.32307244364314 no 2291 0.308143004104516 3443 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1238 0333-0287 48.8 µM -0.501836097939743 0.322815809546855 no 2292 0.307891409302594 3298 7226
SGTC_2378 9074213 121.43 µM -0.502582477935574 0.322548060144881 no 2293 0.307628925542635 3353 657714
SGTC_2545 solidagenone 89.61 µM -0.502770053074469 0.322480785648719 no 2294 0.307562975385773 3253 6708572 An anti ulcer agent
SGTC_957 1187-1561 14.1 µM -0.503000037586468 0.32239830881096 no 2295 0.307482122866267 3370 1538454
SGTC_2338 7999974 200 µM -0.504037857311357 0.322026235608969 no 2296 0.307117387108064 3329 315925
SGTC_466 geldanamycin 89.2 µM -0.505313095374173 0.321569288735541 no 2297 0.306669473262828 3280 5288382 HSP90 inhibitor.
SGTC_1033 k072-0102 21.3 µM -0.506551186161874 0.32112591070536 no 2298 0.306234883053975 3389 5965931
SGTC_1430 4049-0248 69.1 µM -0.50748608184895 0.320791280028401 no 2299 0.305906899833311 3388 22774488
SGTC_2478 5763493 32.33 µM -0.508127549798381 0.320561761206008 no 2300 0.305681947890054 3293 1365576 YLR208W SEC13
SGTC_805 3852-0218 479 µM -0.509365636318658 0.32011896480346 no 2301 0.305247979277829 3281 6615355
SGTC_3342 9147791 14.508 µM -0.510028130321949 0.319882131759352 no 2302 0.305015877144883 3345 1838168
SGTC_875 0709-0210 25.7 µM -0.510211394885266 0.319816630003154 no 2303 0.304951684978155 3414 6251364
SGTC_11 0438-0307 1.3 µM -0.510393899837693 0.319751405327735 no 2304 0.304887764845355 3401 4011476
SGTC_1974 st069448 26.9 µM -0.512731394798166 0.318916511282899 no 2305 0.304069612768082 3384 6323587 YNR016C ACC1
SGTC_2269 7935389 174.42 µM -0.515554655413912 0.3179093381306 no 2306 0.303082743634996 3357 97605
SGTC_2267 7931562 200 µM -0.516227638179706 0.31766945581617 no 2307 0.302847714534927 3224 934880
SGTC_2618 avocadyne 43.43 µM -0.516661678794646 0.317514784166466 no 2308 0.30269617568444 3326 3015189
SGTC_2203 7227154 166.4 µM -0.517052665954253 0.317375482010496 no 2309 0.302559697400033 3394 896304
SGTC_973 1325-0077 65.9 µM -0.517135957969243 0.317345809805968 no 2310 0.30253062698798 3339 2835149
SGTC_920 mycophenolic acid 780.421 nM -0.517521514934416 0.317208473098121 no 2311 0.302396076984486 3309 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_282 k297-0036 65.7 µM -0.519044360215285 0.316666276579994 no 2312 0.301864903567402 3404 5061378
SGTC_1513 0337-0559 19 µM -0.519842060919237 0.316382418843885 no 2313 0.301586830394112 3274 775073
SGTC_3107 9121808 49.47 µM -0.520182540155192 0.31626129396146 no 2314 0.301468176689004 3383 662681
SGTC_1332 1480-0653 17.5 µM -0.521769971494776 0.315696828456148 no 2315 0.300915249824842 3392 5749438
SGTC_1614 st002383 48.6 µM -0.521988628683909 0.31561911105065 no 2316 0.300839123995506 3405 1947235
SGTC_3188 9110789 49.47 µM -0.522004399005603 0.315613506114581 no 2317 0.300833633870162 3456 849217
SGTC_1920 st075728 45.7 µM -0.522112934746433 0.315574932535866 no 2318 0.300795850526264 3452 3400306
SGTC_689 0833-0039 98 µM -0.522876176678453 0.315303733284547 no 2319 0.300530212061366 3370 5374726
SGTC_2897 9048598 12.99 µM -0.524486799677961 0.314731764627951 no 2320 0.299969999336648 3296 6467404
SGTC_2520 obtusaquinone 4.71 µM -0.525572642742893 0.314346407778544 no 2321 0.299592584362319 3480 5967872
SGTC_758 0868-0029 16 µM -0.528294449096884 0.313381350400328 no 2322 0.29864749186589 3429 762687
SGTC_2839 9003951 25.97 µM -0.531170696620389 0.312362920402054 no 2323 0.297650248638193 3405 2990634
SGTC_1740 st038286 13.222 µM -0.532618428282403 0.311850844566522 no 2324 0.297148871428738 3462 716786
SGTC_823 0417-1665 178 µM -0.533459926180834 0.311553366094675 no 2325 0.296857622135082 3382 3429856
SGTC_2675 theaflavin digallate 100 µM -0.533892652539671 0.311400440577773 no 2326 0.296707902891202 3402 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.535595164391721 0.310799088829538 no 2327 0.296119185736081 3336 71034 A hepatoprotective.
SGTC_100 0086-0128 49.5915 µM -0.536738326228548 0.310395590850814 no 2328 0.29572418908685 3379 93297
SGTC_917 harmaline 728.087 nM -0.53863856112126 0.309725376161639 no 2329 0.295068137310059 3365 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2923 7992654 58.14 µM -0.539122365052808 0.309554838907199 no 2330 0.294901212226944 3377 2985126
SGTC_3012 9080433 71.4286 µM -0.539452160034888 0.309438612147367 no 2331 0.294787449233114 3447 17688859
SGTC_3120 9124077 49.47 µM -0.540536790779896 0.309056499691368 no 2332 0.294413447924565 3441 18774327 YGL155W CDC43
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.541549442574341 0.308699931604135 no 2333 0.294064464189155 3325 2724 A muscle relaxant with antifungal properties.
SGTC_14 0354-0009 295 µM -0.542193013709421 0.308473415366503 no 2334 0.293842773790997 3400 1713507
SGTC_2805 7950783 58.44 µM -0.54236171237667 0.308414050941253 no 2335 0.293784675096939 3414 1178958 YDL195W SEC31
SGTC_2257 7960413 200 µM -0.544463651135625 0.307674807026687 no 2336 0.293061227522739 3383 2974689 YIL048W NEO1
SGTC_889 0919-1524 82.7 µM -0.545205654734781 0.307414033326107 no 2337 0.292806041406915 3392 3905452
SGTC_1412 3909-8563 178 µM -0.545360712756407 0.307359551197502 no 2338 0.292752727672953 3487 23767530
SGTC_2219 9098279 200 µM -0.548481616214242 0.306263876673008 no 2339 0.291680624467244 3436 902349
SGTC_882 0843-0131 351 µM -0.548889726703481 0.306120726573249 no 2340 0.291540564394219 3474 5425421
SGTC_1829 berberine 14.4 µM -0.549231204683426 0.306000971442655 no 2341 0.291423396141121 3476 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1226 3909-7979 35.4 µM -0.549772357543793 0.305811233498157 no 2342 0.291237760256598 3450 6615510
SGTC_1357 1503-1303 39.5 µM -0.553615777971563 0.304465162772014 no 2343 0.289920912821942 3435 292895
SGTC_341 1486-1430 230 µM -0.557311979771065 0.303173145174037 no 2344 0.28865714604784 3372 2054753 YPL210C SRP72
SGTC_2160 5660466 132.927 µM -0.557510250479069 0.30310390843393 no 2345 0.28858942878084 3445 2859134
SGTC_728 3030-5151 22.5 µM -0.558722822753751 0.302680628462434 no 2346 0.288175450455 3457 3125388
SGTC_718 1130-0073 349 µM -0.559537296094095 0.302396464071465 no 2347 0.287897542508179 3536 6740020
SGTC_201 4262-0159 12.803 µM -0.560677306966464 0.301998922850831 no 2348 0.287508769979451 3409 1341029
SGTC_2733 amorolfine 100 µM -0.562007672006577 0.301535298930755 no 2349 0.287055395989006 3442 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_840 0245-0196 390 µM -0.562656555633019 0.301309283282114 no 2350 0.286834386388849 3519 3827528
SGTC_94 0334-0113 514.748 µM -0.56377808654655 0.300918817661819 no 2351 0.286452583501528 3412 6795178
SGTC_2924 9010168 62.78 µM -0.564036019082579 0.300829049667127 no 2352 0.286364809623004 3443 2993929
SGTC_658 3253-0951 102 µM -0.565212660534922 0.300419697690617 no 2353 0.285964563150993 3432 1184878
SGTC_1981 st071826 47 µM -0.565276422059708 0.300397522331523 no 2354 0.285942881621567 3423 11838600
SGTC_1066 ketoconazole 628 nM -0.565882626567036 0.300186729903652 no 2355 0.28573678630631 3499 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2005 4024620 188 µM -0.566301558275902 0.30004109599132 no 2356 0.285594400651685 3477 236743
SGTC_2279 7948423 32.93 µM -0.567357812408621 0.299674050617367 no 2357 0.285235553125383 3521 1247112
SGTC_1898 st060199 18.6 µM -0.567861323973942 0.299499153370754 no 2358 0.285064567783913 3458 688866
SGTC_981 1488-1094 54.9 µM -0.569277825003247 0.299007373059095 no 2359 0.284583806538482 3441 3449522
SGTC_40 0327-0103 19.753 µM -0.569581414365706 0.29890202075135 no 2360 0.284480818543774 3379 409036
SGTC_1477 0139-0234 16 µM -0.569709976173042 0.298857412008114 no 2361 0.28443721130616 3457 620880
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.570122044691864 0.29871445168608 no 2362 0.284297462163684 3475 17037758
SGTC_1391 3442-0225 151 µM -0.570193730735866 0.298689584579766 no 2363 0.2842731538713 3417 5227075
SGTC_1402 3909-7673 35.9 µM -0.570453674393993 0.298599420856596 no 2364 0.28418501692524 3463 5328014
SGTC_2353 9059630 146.67 µM -0.571236559777591 0.298327945046353 no 2365 0.283919649419356 3450 4779114
SGTC_512 prima-1 270 µM -0.573032076071072 0.297705750891508 no 2366 0.283311487947261 3507 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2213 7173844 200 µM -0.57391456905262 0.297400160768239 no 2367 0.28301280684547 3421 892728
SGTC_2428 5615643 7.78 µM -0.573986482700078 0.29737526478818 no 2368 0.282988474223403 3467 2253075
SGTC_1447 4239-0816 81.9 µM -0.575326908282384 0.296911393588935 no 2369 0.282535113231807 3410 1341554
SGTC_80 0159-0065 512.242 µM -0.575655340722539 0.296797785915624 no 2370 0.282424083546391 3467 1548079
SGTC_1042 0350-0096 82 µM -0.575905994405398 0.296711095989617 no 2371 0.282339361825539 3432 3122515
SGTC_901 1112-0062 60.1 µM -0.577640985306664 0.296111358182557 no 2372 0.281753265003099 3464 1908457
SGTC_850 0388-0143 75.9 µM -0.57777289994313 0.296065781747599 no 2373 0.281708726955304 3402 67273
SGTC_827 3253-0474 693 µM -0.577825405289691 0.296047642074793 no 2374 0.281691000635317 3504 5402065
SGTC_149 3970-0822 46.1 µM -0.579137939590301 0.295594350443023 no 2375 0.281248051021824 3521 3114250 YBL034C STU1
SGTC_2287 7945887 168.79 µM -0.579379376819138 0.295511003397789 no 2376 0.281166608241974 3463 1245853
SGTC_196 k015-0023 18.111 µM -0.580331508737759 0.295182421363357 no 2377 0.280845541548419 3462 5211998
SGTC_754 3474-0146 171 µM -0.581812146249619 0.294671785775252 no 2378 0.28034661085398 3343 24762078
SGTC_297 0986-0032 24 µM -0.582199366840063 0.294538310123855 no 2379 0.280216199900619 3422 2847425
SGTC_3095 9117207 49.47 µM -0.582722827292891 0.29435791670441 no 2380 0.280039951832937 3456 17015229
SGTC_2919 7978188 46.38 µM -0.582859833597678 0.294310710414915 no 2381 0.279993830963633 3519 2980291
SGTC_1838 st055369 84.5 µM -0.585881142139513 0.29327059150032 no 2382 0.278977695356001 3481 676036
SGTC_2689 tacrolimus 100 µM -0.586937730869664 0.292907251671028 no 2383 0.278622764058993 3461 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_402 epigallocatechin gallate 10 µM -0.587649309382999 0.292662671776813 no 2384 0.278383853231865 3416 65064 An antioxidant.
SGTC_333 3486-0131 40.1 µM -0.587698702278833 0.292645698241009 no 2385 0.278367273388491 3567 6744690
SGTC_670 4204-0025 119 µM -0.587891740074034 0.292579366489946 no 2386 0.278302480499824 3477 719039
SGTC_1794 st048918 76.9 µM -0.587938355008137 0.292563349688433 no 2387 0.278286835358984 3453 672303
SGTC_980 1473-0395 201 µM -0.588050260049904 0.29252490099492 no 2388 0.278249278970972 3460 768876
SGTC_3134 9127454 49.47 µM -0.588962001140303 0.29221172960657 no 2389 0.277943382177464 3591 24262820
SGTC_2810 7959871 45.46 µM -0.589562137550349 0.292005675601304 no 2390 0.277742120982225 3459 2974535
SGTC_450 aminopyrene 156 nM -0.589672010582303 0.291967958541594 no 2391 0.277705281772352 3489 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1714 st033236 13.627 µM -0.589766612228987 0.291935485639072 no 2392 0.277673564800853 3574 2916566
SGTC_287 k060-0039 29.6 µM -0.590156379881747 0.29180171198009 no 2393 0.277542906571379 3521 5861974
SGTC_3054 9094397 49.47 µM -0.591842022780991 0.291223505081935 no 2394 0.276978190162265 3447 2598354
SGTC_2354 9060492 162 µM -0.593597949854763 0.290621758816343 no 2395 0.276390526291576 3520 6471895
SGTC_2966 9084041 48.03 µM -0.59362299979338 0.290613178554051 no 2396 0.276382147144352 3341 17741380
SGTC_1657 st012939 43.4 µM -0.596479051886078 0.289635683638289 no 2397 0.275427622035465 3528 24207257
SGTC_2049 5262831 67.185 µM -0.59664878121317 0.289577641734878 no 2398 0.275370947659399 3499 763417
SGTC_679 0422-0091 41.4 µM -0.597425988387246 0.289311931969885 no 2399 0.275111503477892 3518 627384 YHR062C RPP1
SGTC_1956 st077085 54 µM -0.597608737690952 0.289249470708501 no 2400 0.275050516323707 3476 24208685
SGTC_399 oxolinic acid 75 µM -0.597812224280432 0.28917992918008 no 2401 0.274982616552874 3445 4628 A DNA gyrase inhibitor.
SGTC_3267 9137951 49.47 µM -0.597813873713289 0.289179365518629 no 2402 0.274982066200898 3476 16643986
SGTC_2738 aclarubicin 5.55 µM -0.598574763046984 0.288919401552648 no 2403 0.274728244728554 3425 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_184 1494-0393 24.714 µM -0.599736201302304 0.288522799007902 no 2404 0.274341028922409 3479 3090647
SGTC_72 0744-0168 198.391 µM -0.601118507232707 0.288051110220722 no 2405 0.273880528736361 3431 677577
SGTC_1205 4161-2785 76 µM -0.602991162089544 0.287412679190423 no 2406 0.273257284313289 3483 3498106
SGTC_1970 st070122 35.8 µM -0.603683804718972 0.287176711092055 no 2407 0.273026941757346 3581 102928
SGTC_3211 9128781 49.47 µM -0.60457341910387 0.28687377365651 no 2408 0.272731236309742 3444 17194361
SGTC_2346 9031566 143.75 µM -0.604580441566086 0.286871382923259 no 2409 0.272728902694353 3449 4771086
SGTC_2504 purpurogallin 52.29 µM -0.60512962975464 0.286684446056977 no 2410 0.272546434146294 3444 5281571 An antioxidant.
SGTC_1782 st039423 80.636 µM -0.60618133711283 0.286326619188876 no 2411 0.272197172154539 3444 2068169
SGTC_465 cgp-37157 41 µM -0.606899893700394 0.286082263608466 no 2412 0.271958674338203 3451 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2080 5212524 12.4 µM -0.607962490787823 0.285721093776068 no 2413 0.271606175832367 3525 260183
SGTC_1396 3511-0007 98.6 µM -0.609385315016293 0.285237825027356 no 2414 0.271134534634587 3501 X1396
SGTC_2185 6113692 200 µM -0.610114009137461 0.284990471645397 no 2415 0.270893143596127 3530 874150
SGTC_2806 7952793 58.44 µM -0.610560649834161 0.284838911167561 no 2416 0.270745240087179 3533 2972490
SGTC_782 0083-0095 30.5 µM -0.611300479416988 0.284587946305273 no 2417 0.270500336835536 3558 3591729 An indicator and reagent.
SGTC_1394 3474-0001 65.7 µM -0.611516830376863 0.284514575729054 no 2418 0.270428739841004 3450 5017666 YIL048W NEO1
SGTC_1146 3579-1023 7 µM -0.611529399575992 0.284510313444753 no 2419 0.270424580608703 3555 X1146
SGTC_863 0466-0191 129 µM -0.611638576805277 0.284473292131095 no 2420 0.27038845447612 3534 765160 YPR165W RHO1
SGTC_1683 st010134 710 nM -0.612498612706524 0.284181739845272 no 2421 0.27010395779177 3536 3818134
SGTC_737 1950-0117 57.9 µM -0.615293255741523 0.283235343230096 no 2422 0.269180535346612 3527 5393513
SGTC_2676 harmalol 100 µM -0.615860987488207 0.283043267670984 no 2423 0.268993135810891 3563 5459187 A monoamine oxidase inhibitor
SGTC_417 st075190 100 µM -0.616753029530884 0.282741597487783 no 2424 0.268698818773036 3568 222757
SGTC_3110 9122132 49.47 µM -0.616953731823571 0.282673745414538 no 2425 0.26863262210709 3614 918317
SGTC_495 decylubiquinone 155 µM -0.617042738951998 0.282643656991576 no 2426 0.268603267939966 3509 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_311 1315-0136 58 µM -0.618109167941507 0.28228327566123 no 2427 0.268251689669761 3591 6759207
SGTC_3124 9127567 49.47 µM -0.618834121429357 0.282038416410925 no 2428 0.268012820650834 3532 17592030
SGTC_660 4031-1742 102 µM -0.619626691251003 0.281770836260618 no 2429 0.267751794941026 3490 6738706
SGTC_2795 7780010 54.55 µM -0.620273777228488 0.281552463802678 no 2430 0.267538778046063 3526 953673
SGTC_1346 1488-2224 62.4 µM -0.621206000198146 0.281238009594763 no 2431 0.267232046027182 3557 3722427
SGTC_1326 1431-2094 10.8 µM -0.62166959160055 0.281081695714359 no 2432 0.267079575309834 3527 616278
SGTC_502 l-744,832 89.3 µM -0.622071727921069 0.280946137279033 no 2433 0.266947352157814 3530 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1343 1487-0095 224 µM -0.622131152588486 0.280926108157437 no 2434 0.2669278160237 3557 4560101 YGL055W OLE1
SGTC_680 0417-1641 114 µM -0.622475751245887 0.280809974570115 no 2435 0.26681454186102 3505 2835990
SGTC_166 k072-0058 166.424 µM -0.622897927570076 0.280667728092915 no 2436 0.266675800003153 3578 5846229
SGTC_2412 st077135 33.4 µM -0.623936795507482 0.280317844394751 no 2437 0.266334547147899 3635 13258915
SGTC_2947 9072639 7.68 µM -0.625631026377577 0.279747692450049 no 2438 0.26577849166477 3573 16488146
SGTC_1825 st052143 62.6 µM -0.626505724685694 0.279453554534711 no 2439 0.265491641593882 3592 674173
SGTC_1097 itavastatin 7.23 µM -0.626816505974955 0.279349083179414 no 2440 0.265389761272723 3571 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1349 flufenamic acid 69 µM -0.628356815914781 0.278831577217339 no 2441 0.264885109903365 3533 3371 A non-steroidal anti-inflammatory.
SGTC_1339 1486-1321 22.7 µM -0.628405170191597 0.278815338934746 no 2442 0.264869275503122 3530 3469382
SGTC_2427 5545055 42.75 µM -0.628445972782292 0.278801637009513 no 2443 0.264855914400529 3560 5372858
SGTC_1567 st069303 68.4 µM -0.630292419256245 0.278181924703822 no 2444 0.264251640946106 3580 5581319
SGTC_1319 1306-0155 43.7 µM -0.630651099122639 0.278061620989815 no 2445 0.264134339815102 3591 3122360
SGTC_1619 st003326 88.7 µM -0.630895340246271 0.277979715352491 no 2446 0.264054479424964 3549 2849032
SGTC_119 0121-0043 24.815 µM -0.631959630869739 0.277622945697304 no 2447 0.263706628198355 3644 1092378
SGTC_1247 0448-0043 5.84 µM -0.632291823545165 0.277511634471199 no 2448 0.263598102700919 3575 3089013 YGL099W LSG1
SGTC_2470 5664817 21.68 µM -0.632989093769629 0.277278063908121 no 2449 0.263370382539755 3592 2859561
SGTC_2543 pimpinellin 60.67 µM -0.633304886445459 0.277172311780683 no 2450 0.26326728146474 3505 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_387 norethindrone acetate 66.7 µM -0.636064424684874 0.276249042740611 no 2451 0.262367215899026 3544 541197
SGTC_1167 k781-0610 148 µM -0.636509555032236 0.276100255283094 no 2452 0.262222177569384 3590 4525169
SGTC_500 h-89 112 µM -0.636668431708762 0.27604715934059 no 2453 0.262170420192272 3618 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1302 1159-0335 255 µM -0.636735115819211 0.276024875274547 no 2454 0.262148698018043 3571 649284
SGTC_1760 st045453 10.4495 µM -0.637183840058845 0.275874946477098 no 2455 0.262002551260282 3585 3323419 YIL048W NEO1
SGTC_1520 flindersine 88 µM -0.638516599612488 0.275429877748211 no 2456 0.261568725970273 3653 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_204 PMA1.184 62.41 µM -0.639401812237302 0.275134460557196 no 2457 0.261280785175806 3598 2252213 YGL008C PMA1
SGTC_719 2810-4230 27.3 µM -0.641354948669532 0.274483203414511 no 2458 0.260646048058829 3556 721079
SGTC_1395 3486-0190 4.35 µM -0.642495915673344 0.274103109735833 no 2459 0.260275620191594 3626 6748079
SGTC_2318 6029776 164 µM -0.642578993473932 0.274075443944655 no 2460 0.26024865864093 3616 818325
SGTC_2779 methotrexate 400 µM -0.64636160306787 0.272817258210818 no 2461 0.259022600480255 3646 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_16 erodoxin 22.806 µM -0.646674028118644 0.272713466460676 no 2462 0.258921467789508 3618 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2046 4110841 106 µM -0.650457383424536 0.271458143072041 no 2463 0.257698410563791 3606 44119630 YMR134W ERG29
SGTC_2772 vinpocetine 57.06 µM -0.650994949123269 0.27128001174455 no 2464 0.257524873678722 3634 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_493 zm226600 134 µM -0.651833127866417 0.271002383582688 no 2465 0.25725441408788 3624 5240098 A potassium channel opener. YCR052W RSC6
SGTC_482 fipronil 114 µM -0.652019469560609 0.270940681283691 no 2466 0.25719430629067 3622 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2796 7949634 45.45 µM -0.653154343034473 0.270565048290945 no 2467 0.256828390565504 3587 2971588
SGTC_2956 9076196 2.52 µM -0.653165474858656 0.27056136504528 no 2468 0.256824802688789 3642 16423868
SGTC_1336 1486-0901 104 µM -0.654276710957252 0.270193810566569 no 2469 0.256466773655844 3575 5006114
SGTC_454 lyso-paf C-16 6.67 µM -0.654789379272209 0.270024323678244 no 2470 0.256301684810851 3544 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1419 3993-2473 62.6 µM -0.654935932146717 0.269975883436228 no 2471 0.256254502209988 3628 704026
SGTC_543 3844-1095 191 µM -0.655199129549482 0.26988889950212 no 2472 0.25616977735028 3597 4230703
SGTC_2048 5246248 200 µM -0.655325360622533 0.269847186457279 no 2473 0.256129147976302 3602 677046
SGTC_1020 4335-0961 93.3 µM -0.658168304870474 0.268908591617923 no 2474 0.255214994407898 3550 669075
SGTC_1715 st032160 10.2275 µM -0.658585483730849 0.26877099853044 no 2475 0.255080993517215 3545 5289825
SGTC_2789 5281112 71.43 µM -0.659006167739697 0.268632285201882 no 2476 0.254945904023978 3615 765948
SGTC_925 2064-1272 59.6 µM -0.659021657523458 0.268627178398445 no 2477 0.25494093067977 3571 6815817
SGTC_3190 9110366 49.47 µM -0.659044898439228 0.268619516227506 no 2478 0.254933468755156 3542 17123768
SGTC_2224 6650123 117.647 µM -0.66014066357115 0.268258384099136 no 2479 0.254581782917996 3583 2908370
SGTC_866 0495-0101 262 µM -0.660314821994908 0.268201009082107 no 2480 0.254525910184054 3565 635694
SGTC_3007 9078383 71.4286 µM -0.661087641730928 0.267946484684767 no 2481 0.254278055105478 3605 6496995
SGTC_2834 9001755 58.44 µM -0.662521705858127 0.26747450518061 no 2482 0.253818464343896 3539 2989575
SGTC_1756 st041558 35.5 µM -0.663419831586983 0.267179127502032 no 2483 0.25353085405615 3694 3955792
SGTC_951 1171-0579 82.7 µM -0.663433300328849 0.267174699124279 no 2484 0.253526542212188 3618 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3184 9108758 49.47 µM -0.665428430478031 0.266519131233606 no 2485 0.25288825283384 3624 902885
SGTC_2386 9075165 157.42 µM -0.665462061110383 0.266508087721548 no 2486 0.252877500851859 3589 16452277
SGTC_1573 oleylamine 1.06 µM -0.667485814975811 0.265843960646377 no 2487 0.252230933719879 3641 5356789 An amine of the fatty acid oleic acid.
SGTC_1906 st060206 94.7 µM -0.66924732640826 0.26526657614157 no 2488 0.251668860600666 3619 5133468
SGTC_2532 xanthone 78.9 µM -0.669535328505962 0.26517223601083 no 2489 0.251577026209947 3540 7020 An insecticide.
SGTC_1865 st057639 52.2 µM -0.669940442850989 0.265039562558249 no 2490 0.251447878549299 3625 688818
SGTC_2166 5933061 31.504 µM -0.670321955445418 0.26491464943263 no 2491 0.251326287006895 3819 2877375
SGTC_2156 5649887 115 µM -0.672175031611529 0.264308349526284 no 2492 0.250736137180438 3679 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1557 sumaresinolic acid 42.3 µM -0.672462006615074 0.264214518643862 no 2493 0.250644809813906 3584 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1266 0828-0227 32.9 µM -0.672767009632514 0.264114811825624 no 2494 0.250547764502609 3597 3913820
SGTC_871 0574-0004 149 µM -0.675081233479186 0.263358906950592 no 2495 0.249812077968638 3603 9551173
SGTC_3344 9148862 3.898 µM -0.676333989128703 0.262950175314735 no 2496 0.249414308757017 3670 4905352
SGTC_1282 0886-0010 32.4 µM -0.676911252675316 0.262761943021371 no 2497 0.249231132051811 3687 2836211 YNL267W PIK1
SGTC_2707 st078556 66.6 µM -0.679836959402898 0.261808998723955 no 2498 0.248303850811513 3619 17250899
SGTC_2556 citropten 84.59 µM -0.682504684860922 0.260941630361536 no 2499 0.247459940719103 3646 2775 A potential DNA crosslinker.
SGTC_345 1362-0200 395 µM -0.682964103675645 0.260792406963421 no 2500 0.247314762718495 3629 1419823
SGTC_793 0488-0545 106 µM -0.683817620486432 0.260515293557834 no 2501 0.24704516924955 3637 292548
SGTC_195 4234-0266 16.654 µM -0.684526072984324 0.26028539374759 no 2502 0.246821515541688 3649 2303354
SGTC_778 3456-2434 196 µM -0.684918538011991 0.260158079992653 no 2503 0.246697663631734 3693 5539063
SGTC_1307 1187-1599 12.2 µM -0.685739651912331 0.259891818486687 no 2504 0.246438648806281 3654 1538471
SGTC_2667 digitoxin 100 µM -0.6862328423514 0.259731959882731 no 2505 0.24628314529975 3618 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2984 9022109 38.96 µM -0.686968080352597 0.25949374026662 no 2506 0.24605142162236 3697 6459207
SGTC_261 5-fluorouridine 15.376 µM -0.690288068753372 0.25841945958424 no 2507 0.245006524741477 3680 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_408 cantharidin 100 µM -0.690769440637027 0.258263888913724 no 2508 0.244855221416064 3647 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3049 9092223 49.47 µM -0.691135942303567 0.258145474772589 no 2509 0.244740057471111 3626 8623917
SGTC_2251 lansoprazole 556 µM -0.692913335924268 0.257571610785177 no 2510 0.244181970027094 3590 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1177 0983-0204 23.6 µM -0.693170584733762 0.257488608228215 no 2511 0.244101252831515 3694 766818
SGTC_1578 josamycin 24.2 µM -0.693466458611337 0.25739316029187 no 2512 0.24400843400855 3603 5282165 A P450 substrate.
SGTC_2898 9056270 58.44 µM -0.693484450172963 0.257387356866485 no 2513 0.244002790475971 3614 19154699
SGTC_2401 5128683 200 µM -0.693537613906508 0.257370208571127 no 2514 0.243986114666167 3627 708373
SGTC_2271 7849410 118.62 µM -0.694381959651615 0.257097939172026 no 2515 0.243721352107349 3641 972430
SGTC_1212 0520-0165 585 µM -0.694457291194329 0.257073654894101 no 2516 0.24369773783949 3779 5403258
SGTC_2831 7999036 19.48 µM -0.694833613374099 0.256952359536711 no 2517 0.243579790181567 3669 2988270
SGTC_3331 9141060 1.957 µM -0.695286035330901 0.256806575288627 no 2518 0.243438031999921 3666 4906567 YPR165W RHO1
SGTC_2321 7390090 138.78 µM -0.695496162049095 0.256738880650872 no 2519 0.24337220778066 3619 649046
SGTC_164 4100-3994 89.624 µM -0.695556697277106 0.256719380283872 no 2520 0.243353246321832 3684 4615967
SGTC_2537 larixol 68.93 µM -0.695763478314517 0.256652775198455 no 2521 0.243288482287073 3677 6708759
SGTC_317 4495-0002 170 µM -0.696123623514206 0.256536792326639 no 2522 0.243175706683693 3658 15991618
SGTC_967 1306-0166 352 µM -0.696986369800635 0.256259060492125 no 2523 0.242905661936186 3654 4437607
SGTC_1117 retinoic acid 1.10837 µM -0.698678764714065 0.255714707158523 no 2524 0.242376403858236 3685 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3056 9094900 49.47 µM -0.699101772994451 0.255578742290878 no 2525 0.242244215294913 3623 25236784
SGTC_2841 9004761 38.96 µM -0.699464213987187 0.255462275227342 no 2526 0.242130984882125 3601 2991039
SGTC_1966 st070145 16.1 µM -0.699516789224851 0.255445382963992 no 2527 0.242114562203412 3628 3748532
SGTC_26 0302-0163 425.158 µM -0.699853784280264 0.255337121343561 no 2528 0.242009310993088 3698 3100915
SGTC_634 1611-4317 11.2 µM -0.702746464216947 0.254408818482192 no 2529 0.241106882890212 3694 2843522
SGTC_2029 5175081 200 µM -0.704144283724486 0.253960872655982 no 2530 0.240671462257588 3690 1380876
SGTC_330 1488-0319 80.1 µM -0.704206810285694 0.253940845043078 no 2531 0.240651995246147 3708 6846614
SGTC_615 k087-0205 167 µM -0.705207044111714 0.253620577177725 no 2532 0.24034069913133 3683 9642773
SGTC_27 0485-0001 32.618 µM -0.70550034250173 0.253526705330735 no 2533 0.240249459438078 3615 2054479
SGTC_1655 st012546 55.1 µM -0.705622099428197 0.25348774168447 no 2534 0.240211588659555 3647 720985 YLR208W SEC13
SGTC_2487 5918373 44.05 µM -0.705832869457061 0.253420300238747 no 2535 0.240146039299124 3710 2876279
SGTC_2973 9094665 17.96 µM -0.707120153154313 0.25300860453469 no 2536 0.239745906488728 3701 25237061 YIL048W NEO1
SGTC_1041 0206-0046 107 µM -0.707256727522707 0.252964946335471 no 2537 0.239703475752486 3712 50494
SGTC_3001 9076041 71.4286 µM -0.707425280266281 0.252911071198849 no 2538 0.239651115668902 3699 16004211
SGTC_3219 9131112 49.47 µM -0.710802966593655 0.251832723146295 no 2539 0.238603171021629 3645 17612988 YMR079W SEC14
SGTC_2593 nobiletin 86.24 µM -0.710955671107785 0.251784028662429 no 2540 0.238555852985458 3665 72344 An anti-infammatory.
SGTC_1881 5652484 16 µM -0.711306088656681 0.251672306153241 no 2541 0.238447289693343 3653 2255129
SGTC_3059 1327-0034 3 µM -0.713215895925814 0.251063868894646 no 2542 0.237856085690046 3658 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2680 butyl paraben 22.24 µM -0.713222679029593 0.251061709282642 no 2543 0.237853987331546 3739 7184 An antifungal and steroid mimetic.
SGTC_3224 9130643 49.47 µM -0.713257588159257 0.251050595031188 no 2544 0.237843188325332 3724 17644395
SGTC_2681 menadione 3.18 µM -0.713857752884553 0.250859557317293 no 2545 0.237657571708898 3718 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2053 5265679 138 µM -0.716319280037862 0.250076837306711 no 2546 0.23689711226613 3673 764595
SGTC_1862 st057513 3.81 µM -0.716507308134607 0.250017101167168 no 2547 0.236839078276643 3678 5393163
SGTC_1964 st076914 61 µM -0.716616992943646 0.249982258025858 no 2548 0.236805228185594 3731 24208661
SGTC_224 benfluorex 43.875 µM -0.718132229236182 0.249501182672603 no 2549 0.236337879827453 3689 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1746 st038117 42 µM -0.721775577790468 0.248346465243128 no 2550 0.235216233456444 3762 2898218
SGTC_1836 st055642 81 µM -0.72255449338833 0.248099967054878 no 2551 0.234976817371698 3722 8571
SGTC_616 4092-0450 108 µM -0.723067388007271 0.247937726031167 no 2552 0.234819241977592 3751 787165
SGTC_148 3253-0744 288.01 µM -0.724461063428667 0.247497158760165 no 2553 0.234391361531282 3674 6893655
SGTC_400 oxethazaine 37.5 µM -0.724668117525376 0.247431740735241 no 2554 0.234327829472645 3724 4621 A local anesthetic.
SGTC_286 k060-0067 22.9 µM -0.725472051385026 0.247177828234953 no 2555 0.234081242406158 3700 5985051
SGTC_2288 7946289 167.31 µM -0.728219283721011 0.246311201848613 no 2556 0.233239681602887 3731 1246052
SGTC_1555 citronellol 128 µM -0.728658102734151 0.246172925505436 no 2557 0.233105413703207 3682 8842 A terpine precursor.
SGTC_2302 7771753 200 µM -0.728768278466911 0.246138214548438 no 2558 0.233071709361231 3717 2203047
SGTC_1063 disulfiram 1.84 µM -0.7289803515228 0.24607140814416 no 2559 0.233006840779681 3722 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1236 0330-0013 258 µM -0.729048905837931 0.246049814518998 no 2560 0.23298587363539 3729 4617066
SGTC_47 0149-0135 24.25 µM -0.729184114823127 0.246007228609342 no 2561 0.232944523419455 3710 5239155
SGTC_1479 0549-0158 134 µM -0.729423997665099 0.245931683976905 no 2562 0.232871171409376 3768 5440202
SGTC_1872 amphotericin b 148 nM -0.729440629929241 0.245926446555351 no 2563 0.232866086027382 3733 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_519 k048-0011 62.8 µM -0.729664462591337 0.245855968528761 no 2564 0.232797654288523 3761 6836379
SGTC_2355 9061122 103.12 µM -0.729841821729427 0.245800131285873 no 2565 0.232743438707084 3738 5302957
SGTC_3272 9137413 49.47 µM -0.730281725432415 0.245661667612345 no 2566 0.232608998141135 3681 17614870
SGTC_2447 5741742 33.78 µM -0.730642239206656 0.245548223875447 no 2567 0.23249885241466 3765 1776504
SGTC_938 3126-1755 342 µM -0.730956151387362 0.245449467299 no 2568 0.232402968235073 3715 1777771
SGTC_1280 0880-0253 10.1 µM -0.731279952295434 0.245347622100557 no 2569 0.232304086602171 3708 6836607
SGTC_1155 4088-0394 48.2 µM -0.732305925005366 0.245025072647466 no 2570 0.231990931869877 3697 2326248
SGTC_2752 diclazuril 33.15 µM -0.732555007503638 0.244946799511072 no 2571 0.231914940602435 3766 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2711 st079103 59.1 µM -0.733067156605824 0.244785901072218 no 2572 0.231758735294483 3716 54693780
SGTC_1654 st012436 41.8 µM -0.733606587112233 0.244616493357062 no 2573 0.231594272570488 3691 4323132
SGTC_1120 ficusin 1.78878 µM -0.734804267265236 0.244240588704283 no 2574 0.231229353941854 3825 6199 A DNA cross-linker.
SGTC_2035 5154463 94.595 µM -0.735865358866672 0.243907814165332 no 2575 0.23090632036482 3718 2769623
SGTC_2686 alizarin 95.37 µM -0.736913556486392 0.243579323735317 no 2576 0.230587459724003 3725 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2870 9038528 12.99 µM -0.739961710104836 0.242625434312648 no 2577 0.229661614073236 3709 6463316
SGTC_855 0428-0020 25 µM -0.74129939608794 0.242207458238559 no 2578 0.229255963899579 3757 6812414
SGTC_769 0302-0231 76 µM -0.742567371260459 0.241811624764336 no 2579 0.228871824533766 3729 571869 YER009W NTF2
SGTC_1871 st057448 67.3 µM -0.744826332371427 0.241107298296374 no 2580 0.228188356990309 3806 691747
SGTC_759 3486-0358 89.3 µM -0.745936524956145 0.240761558102751 no 2581 0.227852879961387 3748 875103
SGTC_1765 st044815 90.4 µM -0.746510241025869 0.240582995157369 no 2582 0.227679623763106 3773 645695
SGTC_2240 6690706 185.951 µM -0.746702602724639 0.2405231407953 no 2583 0.22762154916612 3672 805876
SGTC_2962 9082311 13.18 µM -0.746911070599722 0.240458284067472 no 2584 0.227558621482163 3745 16459453
SGTC_571 k831-0106 44.2 µM -0.74711884120284 0.240393653746813 no 2585 0.227495914023701 3703 4783639
SGTC_1799 st045822 46.1415 µM -0.747192259276167 0.240370818160762 no 2586 0.227473757967107 3736 3674992
SGTC_1439 4092-1168 46 µM -0.747480885375046 0.2402810568143 no 2587 0.227386668359242 3738 2886240
SGTC_1688 st021091 57.6 µM -0.747551928020668 0.240258965690117 no 2588 0.227365234938584 3784 3656366
SGTC_366 0181-0206 4.31 µM -0.748784748340906 0.239875789329194 no 2589 0.226993476875494 3736 274874
SGTC_818 4072-2707 53.5 µM -0.749181318681304 0.239752601079725 no 2590 0.226873963642655 3676 882871
SGTC_428 3448-4153 16.5 µM -0.752715012151308 0.238656441239307 no 2591 0.225810593441919 3737 3834874
SGTC_776 4476-4378 112 µM -0.75279357110692 0.238632103273052 no 2592 0.225786985307659 3815 2892008
SGTC_3310 9130229 44.1445 µM -0.752855758331334 0.238612838316076 no 2593 0.225768298112056 3828 7761258
SGTC_191 3914-0123 66.505 µM -0.753041657989542 0.238555253606301 no 2594 0.225712440676907 3706 3144412
SGTC_2851 9015922 71.43 µM -0.753394856107971 0.238445867095792 no 2595 0.225606336465815 3754 2996893
SGTC_599 1935-0052 86.5 µM -0.754046043826547 0.238244264329726 no 2596 0.225410787237367 3756 9557311
SGTC_1189 1431-2119 7.28 µM -0.757255995059736 0.23725185378686 no 2597 0.224448254503418 3780 3107275
SGTC_2826 7992541 19.48 µM -0.757921136817522 0.237046498357962 no 2598 0.224249097907613 3824 2985066
SGTC_3268 9137683 49.47 µM -0.758813912396183 0.236771017026671 no 2599 0.223981941030898 3781 1953228
SGTC_2254 7938975 95.19 µM -0.759179399525457 0.23665829047074 no 2600 0.22387262374134 3806 2969277
SGTC_1670 st016595 4.04 µM -0.760484746849393 0.236255925604853 no 2601 0.223482441669903 3781 597879
SGTC_2466 5983409 37.09 µM -0.760805395409633 0.236157145428056 no 2602 0.223386655654403 3788 2879657
SGTC_1061 3448-9325 110 µM -0.761104607139459 0.236064989683125 no 2603 0.223297294447787 3704 723482
SGTC_342 k048-0088 23.3 µM -0.761331651856416 0.235995074247971 no 2604 0.223229499889217 3767 6820570
SGTC_2978 9011784 42.97 µM -0.762058097490413 0.235771451548483 no 2605 0.223012665134608 3813 2994934
SGTC_1521 st012942 49.4 µM -0.765319571140661 0.234768909141053 no 2606 0.22204063639024 3824 24207259
SGTC_2702 st077768 96.8 µM -0.769283560448012 0.233553600218874 no 2607 0.220862497160196 3749 6484119
SGTC_2258 7960471 200 µM -0.769496622250424 0.233488377119652 no 2608 0.220799274474636 3781 2974708
SGTC_2211 7117706 200 µM -0.769788076776261 0.233399172576575 no 2609 0.220712806787473 3705 822771
SGTC_2993 9054257 71.4286 µM -0.770437854769028 0.233200365212717 no 2610 0.220520102808341 3764 6470217 YGL055W OLE1
SGTC_2528 xanthyletin 44.79 µM -0.770550382707898 0.233165945492576 no 2611 0.220486740311855 3846 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3116 9124943 49.47 µM -0.770636374678448 0.233139644418733 no 2612 0.220461247199417 3742 41905195 YPL160W CDC60
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.770682271229476 0.233125607403442 no 2613 0.220447641435179 3808 5377381
SGTC_2592 piperlongumine 83.33 µM -0.772805857985952 0.232476642322862 no 2614 0.219818643015343 3813 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_421 streptovitacin 30 mM -0.773340884877289 0.232313297455188 no 2615 0.219660332680214 3888 91467 include heat shock
SGTC_1065 prochlorperazine maleate 2.48 µM -0.775202261164845 0.231745513036441 no 2616 0.219110076139458 3831 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2539 epi(13)torulosol 80 µM -0.7756112204356 0.231620869930741 no 2617 0.218989286655818 3825 6708597
SGTC_949 1165-0505 146 µM -0.778003115593384 0.23089261400681 no 2618 0.218283588243735 3841 6244267
SGTC_575 k072-0246 11.9 µM -0.778037029939554 0.230882297369066 no 2619 0.21827359167442 3823 6796779
SGTC_1778 st046819 58.9 µM -0.778506865798527 0.230739401260118 no 2620 0.218135130321246 3848 671715
SGTC_1060 3448-7350 82 µM -0.780634908639207 0.230092796262028 no 2621 0.217508627053101 3736 570178
SGTC_3104 9120930 49.47 µM -0.780778493205814 0.230049204687652 no 2622 0.217466392690642 3827 17014836
SGTC_2250 alverine citrate 130 µM -0.781361607270707 0.229872221600906 no 2623 0.21729492256303 3720 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2928 9011484 9.79 µM -0.781680036685076 0.229775606109531 no 2624 0.217201318396278 3830 2994751
SGTC_558 k064-0027 21.3 µM -0.782479744996146 0.229533064835108 no 2625 0.216966342244162 3846 5088526
SGTC_329 k048-0121 21.3 µM -0.785102748105788 0.228738549334582 no 2626 0.216196664308063 3810 6832902
SGTC_188 3229-0966 278.469 µM -0.785371735601981 0.228657159596969 no 2627 0.21611782374701 3865 5722370
SGTC_1130 3454-2858 15.9 µM -0.785847982977991 0.228513097443399 no 2628 0.215978275910797 3861 715628 YIL048W NEO1
SGTC_346 4513-0042 7.16 µM -0.78676631765029 0.228235450371322 no 2629 0.21570933710203 3791 2827372
SGTC_103 0844-0104 51.839 µM -0.78695196797727 0.228179344355574 no 2630 0.215654992094432 3804 5375804
SGTC_2369 9071472 200 µM -0.787031949236083 0.228155175337947 no 2631 0.215631581805173 3899 17296037
SGTC_299 1273-0059 1.44 µM -0.787257085565232 0.22808715058045 no 2632 0.215565692947599 3745 2848077
SGTC_743 1275-0778 158 µM -0.787337126279915 0.228062969092607 no 2633 0.215542270882314 3823 2849257 YMR203W TOM40
SGTC_1019 4262-0212 3.4 µM -0.787913330871455 0.227888931689685 no 2634 0.215373701487701 3853 4677213
SGTC_3051 9093778 49.47 µM -0.788667854165437 0.227661147762081 no 2635 0.215153080425351 3835 17217378
SGTC_2935 9038016 29.96 µM -0.788771166659733 0.227629968611018 no 2636 0.215122882278682 3819 6463195
SGTC_934 2950-0684 338 µM -0.790650174067478 0.227063314017175 no 2637 0.21457407964149 3865 1121253
SGTC_1725 st036284 20.55 µM -0.791150788742722 0.226912477311747 no 2638 0.214428002277601 3906 707914
SGTC_108 0509-0257 621.132 µM -0.792602864226099 0.226475282464777 no 2639 0.214004619720898 3787 536624
SGTC_3164 9100705 49.47 µM -0.793637033682823 0.226164202120933 no 2640 0.213703383197006 3824 17174235
SGTC_2272 7805186 180 µM -0.793740498049127 0.226133093114562 no 2641 0.2136732593293 3815 2956062 YPR165W RHO1
SGTC_1969 st069479 40.1 µM -0.795302435266106 0.225663753694391 no 2642 0.213218798655119 3822 3895485
SGTC_2155 5570423 76 µM -0.795561394292998 0.225585993570168 no 2643 0.213143506544843 3778 797402
SGTC_2322 7413319 38.22 µM -0.796141075128598 0.225411982189398 no 2644 0.212975021071174 3890 1840400
SGTC_591 4299-0174 154 µM -0.796199438245143 0.225394466680092 no 2645 0.212958062013753 3825 5509088
SGTC_1071 trifluoperazine 6.31 µM -0.7969531690254 0.225168331788985 no 2646 0.212739114989257 3920 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2963 9082507 9 µM -0.797411837823857 0.225030784547721 no 2647 0.212605943209853 3862 16459611
SGTC_584 0986-0246 15.4 µM -0.797621745458986 0.224967852579468 no 2648 0.212545014008845 3919 53315 YDR232W HEM1
SGTC_2938 9059746 27.26 µM -0.799647426223042 0.224361050320079 no 2649 0.211957550631967 3840 6471769
SGTC_517 1365-0151 113 µM -0.800336844448361 0.224154743923606 no 2650 0.211757830740622 3908 768657
SGTC_2331 7980721 200 µM -0.801519526102195 0.223801080942219 no 2651 0.211415472322686 3809 2981221
SGTC_480 am 92016 50 µM -0.801909950791058 0.223684400042382 no 2652 0.211302524801556 3766 2129 K+ channel blocker.
SGTC_447 ml7 120 µM -0.807727621838787 0.221949854710671 no 2653 0.209623699457902 3866 4216 Selective myosin light chain kinase inhibitor.
SGTC_2911 7942208 15.64 µM -0.808344767490951 0.221766303692584 no 2654 0.209446069006495 3860 1243384
SGTC_568 1193-0097 7.48 µM -0.808694270124008 0.221662393342066 no 2655 0.209345512416424 3717 3646150
SGTC_714 4296-0578 26.1 µM -0.808960493494788 0.221583261353623 no 2656 0.209268935452829 3875 1589775
SGTC_1057 3448-5381 134 µM -0.809439805236668 0.221440831884591 no 2657 0.209131106943485 3886 5497911
SGTC_1604 st002052 72.4 µM -0.809494462570361 0.221424593556895 no 2658 0.209115393347157 3872 6254834 YHR062C RPP1
SGTC_2848 9016370 25.97 µM -0.809529789380138 0.221414098560595 no 2659 0.209105237509435 3816 7894410
SGTC_2506 ethyl hematommate 54.16 µM -0.809544720972153 0.221409662723253 no 2660 0.209100945026145 3930 3940691 An allergen.
SGTC_250 brefeldin a 552.239 µM -0.811576311437017 0.220806597230117 no 2661 0.208517394244047 3725 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_499 genistein 192 µM -0.812951963325694 0.220398777825824 no 2662 0.20812280003257 3850 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1602 st001878 87.6 µM -0.813420930295521 0.220259848785032 no 2663 0.207988381581393 3878 595405 YLR310C CDC25
SGTC_2308 7584454 197.62 µM -0.813521206914167 0.220230148872762 no 2664 0.207959646278566 3861 893577
SGTC_2002 4023503 131 µM -0.813964771898609 0.220098801418058 no 2665 0.207832566260063 3857 4736863 YCR052W RSC6
SGTC_398 bronopol 33.3 µM -0.813981987809992 0.220093704387545 no 2666 0.207827634878564 3761 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2391 6285546 200 µM -0.816280235147264 0.219413881638515 no 2667 0.207169938027399 3840 846083
SGTC_659 k018-0002 107 µM -0.816453599369914 0.219362649395585 no 2668 0.207120375814375 3823 6797879 YHR007C ERG11
SGTC_1016 4226-1401 38 µM -0.817792011530679 0.218967356011655 no 2669 0.206737980151952 3833 2901613
SGTC_2607 solasodine 47.35 µM -0.81824486937142 0.218833699522984 no 2670 0.206608689544918 3883 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2228 7354201 200 µM -0.821617117611471 0.217839891355144 no 2671 0.205647421946089 3876 753451
SGTC_2344 7990960 76.95 µM -0.821929360517303 0.217748004614616 no 2672 0.205558550822877 3841 140813
SGTC_2917 7979103 53.79 µM -0.823718264719324 0.217221997663062 no 2673 0.205049829460929 3920 2980565
SGTC_2747 doxorubicin 7.63 µM -0.824195205982097 0.217081882530104 no 2674 0.204914325285156 3759 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_638 3970-0837 4.09 µM -0.824382856849951 0.217026769040756 no 2675 0.204861026240181 3847 4118451 YLR208W SEC13
SGTC_802 4112-3352 742 µM -0.824500051315764 0.216992352860308 no 2676 0.204827743323026 3963 704594
SGTC_262 fenpropimorph 62.5 µM -0.827752646630599 0.216038431347849 no 2677 0.203905298584896 3826 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1884 5633444 25 µM -0.827999438701124 0.215966151427115 no 2678 0.20383540888683 3896 5724239
SGTC_2925 9010536 32.5 µM -0.828043568716897 0.215953228201613 no 2679 0.203822913096148 3833 2994177
SGTC_1031 k035-0009 16 µM -0.828790184197733 0.215734654004291 no 2680 0.203611571766968 3956 5180959
SGTC_3213 9129884 49.47 µM -0.829490926072195 0.215529626173601 no 2681 0.20341333462023 3877 17190742
SGTC_1240 0356-0016 42.1 µM -0.830735668083212 0.21516570987171 no 2682 0.203061486019649 3871 4305613
SGTC_1416 3966-0321 25.3 µM -0.832920269768471 0.214527876603736 no 2683 0.202444848528627 3895 582530 YLR208W SEC13
SGTC_3143 9086658 49.47 µM -0.834699131045293 0.214009319359727 no 2684 0.201943565522135 3966 25236626
SGTC_370 0180-0345 38.7 µM -0.83494512792239 0.21393766608656 no 2685 0.201874302143949 3782 3989527
SGTC_1410 3909-8106 77.9 µM -0.839633197060088 0.212574810143524 no 2686 0.200557040035622 3921 1039210
SGTC_1338 1486-1223 76 µM -0.841176393372276 0.212127303420032 no 2687 0.200124561628407 3921 3444526
SGTC_3011 9081274 71.4286 µM -0.842121033489666 0.211853642149361 no 2688 0.199860104486354 3894 6625322
SGTC_1569 carminic acid 40.6 µM -0.843430831109784 0.211474537074822 no 2689 0.199493767467645 3959 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3352 9151559 45.5865 µM -0.843455693163473 0.2114673448981 no 2690 0.19948681771623 3883 17159339
SGTC_126 0417-1624 672.48 µM -0.844524343676781 0.211158337579991 no 2691 0.199188232967922 3949 41912 YDL195W SEC31
SGTC_1027 k015-0025 8.67 µM -0.845278994216135 0.210940284912204 no 2692 0.198977543185695 3887 3598955
SGTC_911 3456-4043 236 µM -0.845341515415458 0.210922225634211 no 2693 0.198960094009436 3955 914281
SGTC_820 1582-0060 59.9 µM -0.845589785336115 0.210850521698162 no 2694 0.198890812924304 3914 3848840
SGTC_764 1951-2361 146 µM -0.846402068887422 0.210616022403639 no 2695 0.198664242372151 3881 5438930
SGTC_2014 4013930 200 µM -0.846810702181304 0.210498111354737 no 2696 0.198550321005896 3838 64556
SGTC_52 0329-0193 875 nM -0.847018023660797 0.210438303604167 no 2697 0.198492537687393 4006 3739292
SGTC_790 1575-0012 79.1 µM -0.847109698983842 0.210411860442571 no 2698 0.198466989762091 3985 378741 YLR208W SEC13
SGTC_285 1486-1325 46 µM -0.847116918723142 0.210409778037728 no 2699 0.198464977861522 3927 22310230
SGTC_2513 baicalein 25.65 µM -0.848232226511858 0.210088232745477 no 2700 0.198154326564661 3910 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2270 7924575 90.91 µM -0.849327689207294 0.209772690025834 no 2701 0.197849488759045 3919 1262135
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.849452545744985 0.209736743402297 no 2702 0.197814762537681 3937 5024745
SGTC_1638 st008370 60.6 µM -0.85056001291766 0.209418058389477 no 2703 0.197506905049336 3870 24207134
SGTC_2652 actinonin 100 µM -0.851932557271586 0.209023490345729 no 2704 0.197125762742077 3886 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3096 9117468 49.47 µM -0.852051963943954 0.208989184987183 no 2705 0.19709262572022 3839 41316311
SGTC_3150 9097574 49.47 µM -0.852600886705082 0.208831522966828 no 2706 0.196940335348732 3911 17217476
SGTC_2655 perillic acid 100 µM -0.853848148390285 0.208473544135449 no 2707 0.196594566257474 3942 5702197 An apoptosis inducer.
SGTC_614 0462-0418 107 µM -0.853977611004812 0.20843640757757 no 2708 0.19655869737945 3722 5188303
SGTC_1904 st060225 78 µM -0.855643184006513 0.207958983368037 no 2709 0.196097587891303 3862 66595
SGTC_760 0568-0725 82.9 µM -0.857080202608571 0.207547591879602 no 2710 0.195700280764786 3943 3916171
SGTC_1662 st014054 52 µM -0.859479824274963 0.206861698290652 no 2711 0.195037923240017 3928 2838777
SGTC_2263 7948595 193.29 µM -0.861664056689867 0.206238538269171 no 2712 0.194436205099144 3889 2971371
SGTC_532 1548-0774 215 µM -0.861997597513879 0.206143477329527 no 2713 0.194344419946648 4070 5932993
SGTC_2072 5231554 129 µM -0.864457558617593 0.205443177817976 no 2714 0.193668292699283 3974 789545
SGTC_2368 9071271 200 µM -0.864923581046735 0.205310670321573 no 2715 0.193540366908293 3942 27209959
SGTC_269 exalamide 29 µM -0.865405548947233 0.205173682352997 no 2716 0.193408118224608 3847 3316 A derivative of salicylamide.
SGTC_2595 hexamethylquercetagetin 100 µM -0.866321612990576 0.204913462596125 no 2717 0.193156908570412 3907 386331
SGTC_2165 5727197 32.143 µM -0.866467880968045 0.204871931473265 no 2718 0.193116816364899 4099 1361712
SGTC_3218 9131285 49.47 µM -0.866567230961834 0.204843725031043 no 2719 0.193089587325309 3874 17156417
SGTC_609 0986-0026 86.3 µM -0.871330423717459 0.203494118892044 no 2720 0.191786881645992 3889 2848610
SGTC_1431 4049-0260 9.09 µM -0.871501692430142 0.203445690495312 no 2721 0.191740141089476 3908 3854841
SGTC_1808 st050063 61.5 µM -0.871947130290553 0.203319769500177 no 2722 0.191618610317925 3893 4011993
SGTC_1448 4255-0083 152 µM -0.872332829013542 0.203210773763719 no 2723 0.191513416561646 4001 5399660
SGTC_3278 9139605 49.47 µM -0.872983321721445 0.20302702814675 no 2724 0.191336084240606 3977 7958859
SGTC_83 0170-0301 39.027 µM -0.874644740263419 0.202558175359201 no 2725 0.190883618061058 3861 3089716
SGTC_1938 st074717 56.4 µM -0.874988364581894 0.202461285314792 no 2726 0.190790118342278 3768 17250979
SGTC_2193 5925765 200 µM -0.875911856943084 0.202201030097904 no 2727 0.190538976587875 3921 877370
SGTC_1269 0831-0796 3.05 µM -0.876502122279352 0.202034788590095 no 2728 0.190378561576625 3983 927758
SGTC_144 4161-2749 112.381 µM -0.877926235412754 0.201634040244784 no 2729 0.189991875332324 3847 797501 YMR168C CEP3
SGTC_1180 1193-0155 285 µM -0.878604637249005 0.201443304144625 no 2730 0.189807840293975 3997 2921347
SGTC_2121 5257820 149.641 µM -0.880350375052675 0.200952978529878 no 2731 0.189334765429637 4003 791256
SGTC_686 1319-0111 510 µM -0.88208811335378 0.200465611544755 no 2732 0.188864579843799 3956 4562600
SGTC_1741 st038134 10.228 µM -0.882548324608233 0.200336659456436 no 2733 0.188740179570413 4006 1272587
SGTC_935 2996-0153 430 µM -0.883191302374736 0.200156579311293 no 2734 0.188566460048589 3959 23738523
SGTC_1222 0366-0074 1.18 µM -0.883579487001308 0.20004790673486 no 2735 0.188461628196719 3992 286520
SGTC_1702 st027038 51 µM -0.884905661434234 0.199676910885833 no 2736 0.188103757157419 3978 5521182
SGTC_822 1487-0950 154 µM -0.885120205557085 0.199616931327986 no 2737 0.188045901401944 3968 1958375
SGTC_3263 9137018 49.47 µM -0.886979239962298 0.199097659909066 no 2738 0.18754503877029 3964 43844957
SGTC_2606 farnesol 9.78 µM -0.887592347215107 0.19892658344883 no 2739 0.187380035827614 4004 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2895 9054447 58.44 µM -0.889843583886268 0.198299176973688 no 2740 0.186774940151964 3992 2697450
SGTC_272 doxorubicin 8.13 µM -0.890827818904408 0.198025252065556 no 2741 0.186510774246397 3934 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2724 maprotiline 69.64 µM -0.892144567872515 0.197659141933958 no 2742 0.186157724592314 3878 4011 A tricyclic antidepressant.
SGTC_1308 1187-1617 41.4 µM -0.893439734581473 0.197299431941217 no 2743 0.185810865980349 3963 2882570
SGTC_3138 9097216 49.47 µM -0.893463826674881 0.197292744535449 no 2744 0.185804417676436 3935 25237486
SGTC_2326 6164455 177.58 µM -0.897571768985818 0.196154480865253 no 2745 0.184706947695588 3972 2888790
SGTC_3205 9113483 49.47 µM -0.897967049625706 0.196045163574 no 2746 0.184601558249115 4035 17018033
SGTC_529 4076-0302 30.3 µM -0.898803370036772 0.195813995859808 no 2747 0.184378702371226 3921 5816522
SGTC_987 1497-1013 404 µM -0.899216482988119 0.195699868181821 no 2748 0.184268681169855 3909 1676435
SGTC_777 1315-0167 517 µM -0.901151230274511 0.195165907362713 no 2749 0.183753958657274 4005 4221767
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.903747014769718 0.194450902818086 no 2750 0.1830647815653 4051 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2729 fluphenazine 10.66 µM -0.906105524019936 0.193802639850258 no 2751 0.182440000887212 3919 3372 An atypical antipsychotic.
SGTC_17 0960-0276 49.807 µM -0.906265653558909 0.19375867424515 no 2752 0.182397630131004 3967 6821114
SGTC_392 N-ethylmaleimide 8.33 µM -0.906343778723099 0.193737226193124 no 2753 0.182376960209892 3917 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.906357922531169 0.193733343384756 no 2754 0.182373218276338 4015 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1284 0929-0043 16 µM -0.908637056234894 0.193108287445225 no 2755 0.181770869718654 3945 1239883
SGTC_3060 1327-0027 12.5 µM -0.909074317234819 0.192988508857819 no 2756 0.181655449169587 3892 16000455 YPR107C YTH1
SGTC_1456 k015-0012 13 µM -0.913148642593884 0.191874614090721 no 2757 0.18058218518109 3967 2989616
SGTC_842 0271-0008 11.1 µM -0.913788967519766 0.19169991187693 no 2758 0.180413872309339 4043 1221709
SGTC_2484 5809818 12.04 µM -0.915326417365237 0.191280841671184 no 2759 0.180010147313585 3963 2870548
SGTC_1736 st036774 51 µM -0.917772626141091 0.19061522520477 no 2760 0.17936895811139 4072 1272247
SGTC_1734 st037168 69.4 µM -0.918715969316727 0.190358920676868 no 2761 0.179122077392311 4067 708907
SGTC_2082 5219693 150 µM -0.91888730729729 0.190312391201093 no 2762 0.179077259773388 3980 2834649
SGTC_2097 5376186 200 µM -0.919157721946183 0.190238970140344 no 2763 0.179006540595545 3958 742755
SGTC_702 1488-0190 94 µM -0.91928720256714 0.190203820645594 no 2764 0.178972684883736 4025 949357
SGTC_2132 5317594 122.667 µM -0.919718857124331 0.190086670241365 no 2765 0.178859847896439 3967 794577
SGTC_2458 5808907 16.39 µM -0.92009437995401 0.189984789981626 no 2766 0.178761720495899 4131 2731747
SGTC_2976 9009005 19.48 µM -0.922253975539059 0.189399538224888 no 2767 0.178198057381297 4024 2993148
SGTC_1962 st076595 64.5 µM -0.923457199095437 0.189073945756051 no 2768 0.177884497681651 3996 279619
SGTC_3202 9113761 49.47 µM -0.924531435897657 0.188783548591588 no 2769 0.177604846108303 4040 4798415
SGTC_2149 5554786 194.827 µM -0.925334064337342 0.188566754510573 no 2770 0.177396082394081 4017 745063 YPR165W RHO1
SGTC_2282 7944268 200 µM -0.926368283550735 0.188287633003738 no 2771 0.177127310430757 4031 2970414
SGTC_2873 9040596 71.43 µM -0.928132402519438 0.187812110212753 no 2772 0.176669446737816 4006 6463863
SGTC_2300 7976697 71.57 µM -0.930716486634316 0.187116903996031 no 2773 0.176000119592945 3913 2236109
SGTC_1985 st071382 65.5 µM -0.930975933464557 0.187047192037696 no 2774 0.175933006716724 3992 6123237
SGTC_690 glyoxal 20.3 µM -0.931946084608906 0.186786660066831 no 2775 0.175682194746897 3817 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_438 sphingosine 6.67 µM -0.932242345590803 0.186707144616341 no 2776 0.17560564793952 3966 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_173 1273-0061 2.693 µM -0.932352418239062 0.186677606827876 no 2777 0.175577213165057 4004 2847414 YPL266W DIM1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.933312980899426 0.186419964437378 no 2778 0.175329197414012 4083 6710655
SGTC_3072 9116419 49.47 µM -0.933388115078333 0.186399821218826 no 2779 0.175309807260016 4047 17170162
SGTC_666 0272-0154 136 µM -0.93459680506968 0.186075960863008 no 2780 0.174998063084372 4022 6870312
SGTC_2797 7859098 81.82 µM -0.939821203618775 0.184680134444235 no 2781 0.173654640331416 4010 972681
SGTC_1182 1222-0449 220 µM -0.942080180703399 0.184078614519771 no 2782 0.173075795346773 4018 658318
SGTC_2465 5809242 33.21 µM -0.942537148675478 0.183957081671019 no 2783 0.172958850554619 4045 2731748
SGTC_2526 patulin 37.61 µM -0.945680401821547 0.183122472680837 no 2784 0.172155810729058 4074 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3236 9132701 49.47 µM -0.946442925306522 0.18292036099888 no 2785 0.171961360072595 4024 24282524
SGTC_2662 daunorubicin 22.37 µM -0.946971050201878 0.182780459779334 no 2786 0.171826765485019 3924 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1753 st043925 64 µM -0.949951829280669 0.181992099076847 no 2787 0.171068364796008 4087 670181
SGTC_471 1-acyl-paf 4 µM -0.951729183993249 0.181523035197696 no 2788 0.170617172312554 3964 16759367
SGTC_1623 st003709 20.3 µM -0.952560420213614 0.181303922557267 no 2789 0.170406419568578 3997 16192618
SGTC_2580 diallyl disulphide 81.36 µM -0.952663501026934 0.181276762154512 no 2790 0.17038029594641 4027 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2585 alliin 100 µM -0.953385365837444 0.181086631928731 no 2791 0.1701974266706 4095 87310 A garlic compound which reacts with lipids.
SGTC_2245 6637752 200 µM -0.953865637705519 0.180960203519986 no 2792 0.170075829584956 4105 681890
SGTC_795 0685-0265 78 µM -0.954506559832324 0.180791571172417 no 2793 0.169913645199112 4061 302754
SGTC_2102 5377816 72.7585 µM -0.956472843343715 0.180274839343394 no 2794 0.169416699051469 4088 1379702
SGTC_1427 4048-4900 550 nM -0.958335875051756 0.179786097715876 no 2795 0.168946709580824 4022 24132586
SGTC_3288 9119690 36.221 µM -0.959132832172553 0.17957728103369 no 2796 0.168745916172372 4039 17595618 YKL019W RAM2
SGTC_1712 st032288 53.4 µM -0.959686899956912 0.179432195459657 no 2797 0.168606409161948 3957 2883011
SGTC_2286 7945697 125 µM -0.960072751371038 0.179331201771019 no 2798 0.168509300635319 4081 1245733
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.960460270918821 0.179229807444347 no 2799 0.168411808484192 4088 5393153
SGTC_2136 5328288 199.296 µM -0.96451111502214 0.178172065055583 no 2800 0.167394869273773 4049 262395
SGTC_661 1304-0007 33.6 µM -0.964529574926264 0.178167253893236 no 2801 0.167390244105498 4048 3117130
SGTC_379 3970-0972 5.9 µM -0.966066221894486 0.177767048280869 no 2802 0.167005522691621 4037 2898042 YBL034C STU1
SGTC_3253 9135987 49.47 µM -0.969588086227409 0.176851952367419 no 2803 0.166125926875214 4064 4182430
SGTC_3251 9135047 49.47 µM -0.970500491237128 0.176615366057217 no 2804 0.165898540085979 4067 17682963
SGTC_1942 st076330 65.2 µM -0.970559701083173 0.176600019882719 no 2805 0.165883790942979 4105 24208414
SGTC_1583 clindamycin 39.6 µM -0.973516440643139 0.175834756428181 no 2806 0.165148346587867 4043 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1025 k007-0731 70 µM -0.973697241247683 0.175788029852653 no 2807 0.165103443744562 4027 6256118
SGTC_15 0266-0086 27.098 µM -0.973774020552888 0.175768189190157 no 2808 0.16508437756489 4112 1712902 YIL048W NEO1
SGTC_527 4476-4215 268 µM -0.976312760887468 0.175112948315377 no 2809 0.164454749071514 4042 4418754
SGTC_1356 1502-0781 85.8 µM -0.980516126356701 0.174031484315547 no 2810 0.16341570666063 4045 567702
SGTC_1729 st035615 45.989 µM -0.981174108964487 0.173862580253477 no 2811 0.16325344480992 4105 17385451
SGTC_1086 cerivastatin 2.18 µM -0.983272577897705 0.173324600235564 no 2812 0.162736651301893 4048 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2958 9077254 16.72 µM -0.983806515637456 0.173187885073337 no 2813 0.162605327546917 4149 16457351
SGTC_85 0868-0259 160.055 µM -0.986439527574613 0.17251470511147 no 2814 0.161958738149594 3993 83173
SGTC_1428 4049-0204 61.7 µM -0.988751699231739 0.171924932128614 no 2815 0.161392320679105 4130 X1428
SGTC_2105 5350118 200 µM -0.990438697242018 0.171495437463577 no 2816 0.160979869419914 4062 2133313
SGTC_908 3448-7491 47.7 µM -0.991442809564406 0.17124012521162 no 2817 0.160734702607332 4084 1203031
SGTC_2811 7967822 32.47 µM -0.991923295632464 0.171118039655813 no 2818 0.160617472109753 4147 2232244
SGTC_1649 st011737 51.3 µM -0.992097559501094 0.171073775125466 no 2819 0.160574968468047 4067 1761035
SGTC_1834 st055981 52.8 µM -0.992777087726123 0.170901239043696 no 2820 0.160409299054754 4105 471719 YDL150W RPC53
SGTC_81 0411-0046 9.971 µM -0.99429277914199 0.170516797657954 no 2821 0.160040175056018 4025 12925265
SGTC_1781 st038725 66.3 µM -0.995745827986742 0.170148765312738 no 2822 0.159686828599732 4061 4270275 YIL048W NEO1
SGTC_403 arphamenine a 50 µM -0.997029386344907 0.169824085746516 no 2823 0.159375123109108 4038 5487158 An arginine aminopeptidase inhibitor.
SGTC_2742 clothiapine 36.27 µM -0.998810921005382 0.169374100560237 no 2824 0.15894314729953 4061 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_567 1080-0542 68.4 µM -0.999039016950243 0.16931654273722 no 2825 0.158887895424821 3954 5950415
SGTC_2041 5107442 45.335 µM -0.999477637150672 0.169205896427724 no 2826 0.158781683460992 4136 793005
SGTC_1926 methyl fluorone black 53.6 µM -1.00034569980108 0.16898705587225 no 2827 0.158571619158884 3815 72721 Reacts with homocysteine.
SGTC_2423 st077119 87.2 µM -1.00200635416592 0.168568907970184 no 2828 0.158170261981339 4018 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_429 1112-0049 25.5 µM -1.00205144989947 0.168557562281014 no 2829 0.158159372273058 4054 2836170
SGTC_2635 hydroquinidine 100 µM -1.00278164484218 0.168373920001591 no 2830 0.157983113442484 4016 442912 An experimental heart treatment.
SGTC_1461 k072-0203 53.8 µM -1.00280686334601 0.168367579907829 no 2831 0.157977028353726 4002 5418714
SGTC_3117 9124945 49.47 µM -1.00431478191187 0.16798875857743 no 2832 0.157613455445097 4003 17592065
SGTC_2565 isoliquiritigenin 100 µM -1.00654604724071 0.167429224348841 no 2833 0.157076486412542 4193 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1679 SEC14.276 6.7 µM -1.0066957950041 0.167391715164172 no 2834 0.157040491740503 4092 1005053 YMR079W SEC14
SGTC_3173 9105693 49.47 µM -1.01074186231802 0.166380296426528 no 2835 0.156069997667106 4112 17096658
SGTC_120 rhodamine 6G 52.259 µM -1.0109801848236 0.166320844892739 no 2836 0.1560129568966 4118 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_227 fluconazole 33.516 µM -1.01138083084376 0.166220931326855 no 2837 0.155917096133722 4092 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2330 7979373 200 µM -1.01247646415709 0.16594789904502 no 2838 0.155655147215122 4042 1863007
SGTC_2771 fluoxetine 41.05 µM -1.01287212801259 0.165849370719671 no 2839 0.155560621505875 4119 3386 A selective serotonin reuptake inhibitor.
SGTC_2085 5307070 144.047 µM -1.01376708861601 0.165626646905201 no 2840 0.155346951488052 4038 2840351
SGTC_208 k072-0098 12.366 µM -1.01451475456874 0.165440727844425 no 2841 0.155168596326136 4075 5948901
SGTC_604 1000-0114 314 µM -1.01582121197039 0.165116180586675 no 2842 0.15485726648539 4122 1572745
SGTC_2879 9041815 71.43 µM -1.01633500115883 0.164988659201958 no 2843 0.154734943233064 4115 4942971
SGTC_2404 5161160 200 µM -1.01685702076211 0.164859160374649 no 2844 0.15461072587934 4065 2831543
SGTC_446 go6976 132 µM -1.01965384468359 0.164166466183785 no 2845 0.153946329349814 4136 3501 A protein kinase C inhibitor.
SGTC_971 1315-0384 26.7 µM -1.02008885126504 0.16405889723379 no 2846 0.15384316185356 4146 6769120
SGTC_1857 st056007 79.3 µM -1.02079115248476 0.163885327865382 no 2847 0.153676698536224 4091 619834
SGTC_3265 9137266 49.47 µM -1.0211940243723 0.163785814395317 no 2848 0.153581261459416 4019 17224265
SGTC_628 1636-0253 16 µM -1.02164391652166 0.163674732803952 no 2849 0.153474732060149 4111 4456143
SGTC_1133 3473-0247 50 µM -1.02460263113758 0.162945423816157 no 2850 0.152775361263595 4098 711311
SGTC_225 nsc-122657 1.016 µM -1.0250025885304 0.162846998588015 no 2851 0.152680983140817 4121 275685
SGTC_3328 9140624 29.0385 µM -1.0250610718006 0.162832609722493 no 2852 0.152667186059456 4132 4904392
SGTC_2036 5160441 105 µM -1.02815788952944 0.162071868726345 no 2853 0.151937781667572 4091 134534 YIL048W NEO1
SGTC_2406 ethylparaben 405.7 µM -1.02851508710313 0.161984271382283 no 2854 0.151853798822142 4136 8434 A possible steroid mimic.
SGTC_838 0109-0203 71.4 µM -1.02928752425126 0.16179494824034 no 2855 0.151672292013959 4119 759422
SGTC_410 α-linolenic acid 100 µM -1.0298455792982 0.16165825957016 no 2856 0.151541250334912 4187 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3132 9126706 49.47 µM -1.03016911910719 0.161579046981675 no 2857 0.15146531166339 4208 850858
SGTC_2933 9026794 32.47 µM -1.0305118797837 0.16149515613583 no 2858 0.151384889229784 4074 17586027
SGTC_1007 4101-0031 70 µM -1.03063353124505 0.161465388709783 no 2859 0.151356352800315 4093 1146276
SGTC_3194 9111903 49.47 µM -1.03118399531577 0.161330737982952 no 2860 0.151227272238982 4168 17087251
SGTC_1860 st056228 74.6 µM -1.03128042023634 0.161307158723934 no 2861 0.151204668706151 4092 688679
SGTC_2436 5633522 8.09 µM -1.03199753437637 0.161131869809971 no 2862 0.151036636275988 4116 5724242
SGTC_1648 st011736 69.8 µM -1.03404724192887 0.160631531933064 no 2863 0.150557039233757 4121 2855514
SGTC_716 1683-5115 658 µM -1.03611996799581 0.160126608182943 no 2864 0.150073088841876 4065 723597
SGTC_1165 k072-0275 30.3 µM -1.03631957473341 0.160078038077175 no 2865 0.150026538475306 4106 6153523 YGL055W OLE1
SGTC_2370 9071495 200 µM -1.03738853114742 0.159818093934938 no 2866 0.149777410569046 4136 21791103
SGTC_2306 7482397 179.52 µM -1.03805213125336 0.15965686156548 no 2867 0.149622892746916 4147 891448
SGTC_1630 st005209 31.3 µM -1.03805519129391 0.159656118325814 no 2868 0.14962218046968 4098 3367314
SGTC_3324 9138759 60.749 µM -1.03861050381108 0.159521278420849 no 2869 0.149492959359963 4175 45595710
SGTC_1022 4477-0945 21.3 µM -1.03869350848484 0.159501129793131 no 2870 0.149473650590123 4089 4648966
SGTC_2441 5730946 39.09 µM -1.04041762924126 0.159082991889531 no 2871 0.149072957377177 4190 1774275
SGTC_1300 1094-0077 113 µM -1.04052380921984 0.159057264362305 no 2872 0.149048304160807 4105 5532636
SGTC_2706 st078239 82.5 µM -1.04389250236052 0.158242441501326 no 2873 0.148267563726931 4103 15434492
SGTC_218 alverine citrate 93.75 µM -1.04399253844917 0.158218286624815 no 2874 0.148244420909245 4180 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1718 roemerine 11.9335 µM -1.04494480841801 0.157988471123084 no 2875 0.148024239313595 3877 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3303 9125618 40.5795 µM -1.04630850055102 0.157659747134809 no 2876 0.147709311002932 4153 22695467
SGTC_323 4013-0906 34.3 µM -1.04690331561626 0.157516505188322 no 2877 0.147572086259148 4140 2910086
SGTC_1635 st007035 42.4 µM -1.04963242018973 0.156860385431681 no 2878 0.146943572716513 4109 3716403
SGTC_1350 1495-0454 146 µM -1.05080685159993 0.156578587846544 no 2879 0.146673654169935 4193 1069057
SGTC_1161 k007-0610 110 µM -1.05508522878616 0.155554837849007 no 2880 0.145693173508283 4135 5843850
SGTC_1206 3978-0017 132 µM -1.05523760463379 0.155518458261741 no 2881 0.14565833480926 4240 3873677
SGTC_3214 9129694 49.47 µM -1.05734156992127 0.1550167124136 no 2882 0.145177863883908 4208 17158655
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.05746231286393 0.154987950553369 no 2883 0.145150322881827 4110 2333 A French combination drug.
SGTC_472 calcifediol 10 µM -1.06056196126932 0.154250797951836 no 2884 0.144444508612248 4209 5283731 A vitamin D metabolite.
SGTC_3232 9132874 49.47 µM -1.06211407356364 0.153882550138666 no 2885 0.144091950897513 4110 3784940
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.06314998598219 0.153637097803168 no 2886 0.143856969597071 4153 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2908 7930301 100 µM -1.06377002106252 0.153490308829273 no 2887 0.143716447614382 4136 2223178
SGTC_3145 9085516 49.47 µM -1.06422614217504 0.15338238466027 no 2888 0.143613133512467 4177 25236195
SGTC_2756 carbadox 75.1 µM -1.06518645918943 0.153155325576989 no 2889 0.143395779988237 4121 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1489 4065-0444 182 µM -1.06528631323293 0.153131728699583 no 2890 0.143373192260408 4138 2877968
SGTC_389 tpck 16.7 µM -1.07032332610674 0.151944539960536 no 2891 0.142236899190424 4176 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2670 beta-carotene 100 µM -1.07067436531744 0.151862030986132 no 2892 0.142157936496918 4096 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_804 1595-0054 20.9 µM -1.07209528218773 0.151528359932478 no 2893 0.141838618844004 4103 761523 Stimulates phospholipase C.
SGTC_3327 9140648 26.9345 µM -1.07356869979722 0.151182875370412 no 2894 0.141508016218899 4186 8029710
SGTC_3055 9094636 49.47 µM -1.07562165384034 0.150702376448871 no 2895 0.141048249545762 4200 25236176
SGTC_874 0599-0792 117 µM -1.07567208115567 0.150690586622363 no 2896 0.1410369689239 4199 765305
SGTC_772 k072-0172 35.3 µM -1.07580552146863 0.150659391451469 no 2897 0.141007121194602 4203 5861980
SGTC_3090 9117696 49.47 µM -1.07797901802325 0.150151885169554 no 2898 0.140521559922853 4131 7923821
SGTC_1249 0481-0015 10.2 µM -1.08321603881727 0.148933739035936 no 2899 0.139356271144054 4111 4227577
SGTC_1131 3454-3128 32.3 µM -1.08485240033678 0.148554474318918 no 2900 0.138993516439008 4223 710982
SGTC_1457 k015-0032 57.3 µM -1.08848989529158 0.147713715573898 no 2901 0.138189447509085 4175 4302660
SGTC_993 3909-8757 62.7 µM -1.09043873759894 0.147264580035528 no 2902 0.137759962844853 4120 4288324 YLR208W SEC13
SGTC_713 1488-1073 324 µM -1.09192848012722 0.146921867811972 no 2903 0.13743226917635 4146 3312542
SGTC_280 3448-3607 3.04 µM -1.09198688636883 0.1469084424815 no 2904 0.137419432602395 4151 626179
SGTC_786 4544-0069 423 µM -1.0953930958714 0.146126910129164 no 2905 0.136672228757625 4189 748821 YLR208W SEC13
SGTC_2646 retinol 96.75 µM -1.09718717548406 0.145716395276096 no 2906 0.136279789062709 4201 445354 A vitamin A analog and teratogen.
SGTC_2878 9043973 25.97 µM -1.09876681383629 0.145355590510148 no 2907 0.135934895465149 4243 6465167
SGTC_2067 5224629 34.075 µM -1.09933131323204 0.145226799238014 no 2908 0.135811789392784 4199 2835000
SGTC_12 0849-0099 9.267 µM -1.10356642976446 0.144263001241043 no 2909 0.134890630133675 4103 6071388
SGTC_2464 5717415 7.67 µM -1.10452599563486 0.144045230503515 no 2910 0.134682516672135 4185 5285744
SGTC_1200 1643-0193 18.4 µM -1.10509701360346 0.143915744871005 no 2911 0.134558777250354 4227 5403974
SGTC_3006 9075424 71.4286 µM -1.10674307943918 0.143542917874956 no 2912 0.134202512086756 4163 7465181
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.109696898437 0.142875526218116 no 2913 0.133564829934389 4183 688803
SGTC_1354 1498-1681 81 µM -1.11033928817778 0.142730661508368 no 2914 0.133426424600871 4210 5754243
SGTC_578 3460-0051 92 µM -1.11459009534403 0.141774568914441 no 2915 0.132513058336619 4270 2876744
SGTC_1036 k216-0215 33.5 µM -1.11610452029706 0.141434994414642 no 2916 0.132188698742577 4186 622330
SGTC_2847 9005661 71.43 µM -1.11815052265354 0.14097710208783 no 2917 0.131751355797491 4223 2991449
SGTC_2087 5276107 200 µM -1.11837967193622 0.140925881498022 no 2918 0.131702436265985 4172 144405
SGTC_943 3253-1379 105 µM -1.11843477718603 0.140913565981035 no 2919 0.131690674088372 4225 668464
SGTC_649 1123-0311 367 µM -1.12159213281098 0.140209145178398 no 2920 0.131017949086035 4105 693629 YIL048W NEO1
SGTC_1594 piperine 70.1 µM -1.12283202875297 0.139933173792896 no 2921 0.130754419868687 4183 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2587 piperic acid 92.2 µM -1.12456865746577 0.139547262482453 no 2922 0.130385930721209 4207 5370536
SGTC_676 falcarinol 140 µM -1.12728960675258 0.138944073430745 no 2923 0.129810027605287 4258 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1197 1601-0112 267 µM -1.12748305964327 0.138901255847953 no 2924 0.129769149462298 4190 7350313
SGTC_140 0062-0056 502.533 µM -1.12852825737494 0.138670074110033 no 2925 0.129548445015917 4143 3758964
SGTC_1250 0485-0349 40.2 µM -1.12872530697773 0.138626519136804 no 2926 0.129506865079701 4236 6842794 YDL195W SEC31
SGTC_514 4466-0038 2.65 nM -1.136260099633 0.136968051326365 no 2927 0.127923862219404 4044 5722064
SGTC_2617 dihydrotanshinone i 20.83 µM -1.13829400824053 0.136522705466324 no 2928 0.127498867556117 4194 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1983 st071813 46.9 µM -1.14070881123749 0.135995245945362 no 2929 0.12699555931092 4285 11838595
SGTC_1103 duloxetine 36.1 µM -1.14106576964641 0.135917394907769 no 2930 0.126921277297866 4304 60835 A selective serotonin reuptake inhibitor.
SGTC_3274 9138298 49.47 µM -1.14390864031138 0.135298466755006 no 2931 0.126330763689426 4222 17015756
SGTC_762 1165-0429 115 µM -1.14815795160395 0.134376946007249 no 2932 0.125451682072991 4255 5967793
SGTC_1747 st037496 66.6 µM -1.14904579506798 0.134184950716901 no 2933 0.125268548866242 4209 723305
SGTC_645 0845-0943 5.41 µM -1.14975609531416 0.134031484713799 no 2934 0.125122171502587 4250 1885106
SGTC_1506 4226-2149 212 µM -1.15024060312172 0.133926872170321 no 2935 0.125022393582798 4252 991114
SGTC_3169 9102970 49.47 µM -1.15079726884942 0.133806748929968 no 2936 0.124907824327501 4296 17027839
SGTC_1327 1436-0082 2.18 µM -1.1514820080973 0.133659090231432 no 2937 0.124766996460205 4249 15992205
SGTC_1687 st020778 55.3625 µM -1.1558756136517 0.132714309281429 no 2938 0.123866019385099 4252 4259299
SGTC_2289 7946404 165.07 µM -1.15634641261863 0.132613344342877 no 2939 0.123769745575632 4246 1246120 YPR165W RHO1
SGTC_220 paclitaxel 373.376 µM -1.16119252645803 0.131577148916769 no 2940 0.122781806676421 4199 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3019 9081971 49.47 µM -1.1623685214384 0.131326542677001 no 2941 0.122542902065664 4271 16451803
SGTC_1463 k081-0032 34.1 µM -1.16365584598015 0.13105259003836 no 2942 0.122281754883056 3853 977755
SGTC_1692 fluoroquinolonic acid 71 µM -1.16444726984233 0.130884365014174 no 2943 0.122121400358632 4271 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1378 2093-0007 380 nM -1.1665285453605 0.130442681637397 no 2944 0.121700407144656 4310 3618014
SGTC_1035 k081-0041 55.2 µM -1.16944484310403 0.129825527767732 no 2945 0.121112225787046 4287 731709
SGTC_1227 3909-8010 46.6 µM -1.16970586163495 0.129770389146175 no 2946 0.121059679227773 4235 15982272
SGTC_1406 3909-7906 11.9 µM -1.17219655611043 0.129245060293036 no 2947 0.120559075386487 4267 X1406
SGTC_2200 6600604 21.907 µM -1.17230689869886 0.129221821355055 no 2948 0.120536931435257 4288 2904777
SGTC_3066 9117245 49.47 µM -1.17416738667651 0.128830425387247 no 2949 0.120163993165069 4313 17176980
SGTC_2683 piperine 63.03 µM -1.17493122085882 0.128669973849488 no 2950 0.120011116854118 4240 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1251 0490-5699 265 µM -1.17808513405384 0.128008929214266 no 2951 0.119381333974054 4302 3883818
SGTC_1437 4092-1038 11.6 µM -1.18107278831956 0.127384911148599 no 2952 0.118786904438717 4306 3977136
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.18132169994187 0.127333017725306 no 2953 0.118737475013153 4347 4213774
SGTC_2425 5628681 7.85 µM -1.18194591650995 0.127202944913681 no 2954 0.118613580609761 4337 5714958
SGTC_2877 9040724 71.43 µM -1.18212411314966 0.127165829675895 no 2955 0.118578228936081 4249 6463895
SGTC_1267 0828-0272 9.49 µM -1.18299486727827 0.126984575219408 no 2956 0.118405590808422 4341 745334
SGTC_1828 st055811 49 µM -1.18396328439287 0.126783202715878 no 2957 0.11821379850779 4275 5877589
SGTC_3098 9119039 49.47 µM -1.19102776885185 0.125320941525561 no 2958 0.116821341874684 4275 17161528
SGTC_2665 lovastatin 100 µM -1.20020577146185 0.1234388505123 no 2959 0.115029717206502 4304 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_562 3772-2733 112 µM -1.20199284477057 0.123074698660581 no 2960 0.114683150162401 4275 2876874 YIL048W NEO1
SGTC_2164 5685496 200 µM -1.2027342439317 0.122923845008245 no 2961 0.114539588938751 4213 759046
SGTC_1618 st003135 44.5 µM -1.20973788374349 0.12150519859488 no 2962 0.113189744084723 4267 1270615
SGTC_2220 6782180 200 µM -1.21234236155828 0.120980586790972 no 2963 0.112690677267788 4214 833803
SGTC_3276 9139060 49.47 µM -1.2135897592445 0.120729892629458 no 2964 0.112452209781614 4407 4870619
SGTC_1118 chelidonine 707.474 nM -1.21676050027683 0.120094303776726 no 2965 0.111847676350565 4280 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_696 1560-0013 611 µM -1.22064670223069 0.11931851868492 no 2966 0.111109907816097 4352 1650269
SGTC_156 3474-0145 5.642 µM -1.22141672765694 0.119165222705561 no 2967 0.110964138435211 4201 2265471
SGTC_1503 4585-0012 61.3 µM -1.22532653032632 0.118389007806415 no 2968 0.110226108124391 4332 2922052
SGTC_891 0929-0073 133 µM -1.22722673077892 0.118013053539132 no 2969 0.10986869260807 4343 5603632
SGTC_2138 5575593 77.673 µM -1.22769249140953 0.117921031902785 no 2970 0.109781213083866 4310 762213
SGTC_2450 5739737 12.93 µM -1.22818927466726 0.117822937000868 no 2971 0.10968796198004 4333 2262825
SGTC_1646 st011709 75.6 µM -1.22857893568532 0.117746034891854 no 2972 0.109614858578982 4271 5757843
SGTC_2522 biochanin a 4.94 µM -1.23002239132136 0.117461469174766 no 2973 0.109344360035007 4320 5280373 A possible chelator.
SGTC_1376 2910-0861 41.3 µM -1.23148460829882 0.117173701650138 no 2974 0.109070834914837 4250 1112859
SGTC_1874 staurosporine 7.6 µM -1.23220457786697 0.117032193698454 no 2975 0.108936336841827 4321 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.23393038654159 0.116693484119289 no 2976 0.108614422709546 4360 23847180
SGTC_2388 9080168 200 µM -1.23516255094932 0.116452083493934 no 2977 0.108385006791723 4322 15943073
SGTC_2626 ethyl orsellinate 100 µM -1.23532457582656 0.116420366612399 no 2978 0.108354865440506 4272 75653 A natural product.
SGTC_258 haloperidol 50.781 µM -1.23694962976335 0.116102596084806 no 2979 0.108052891615175 4311 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_174 3553-0389 74.3 µM -1.23752977896855 0.115989300298761 no 2980 0.107945232945966 4377 738071
SGTC_2914 7968218 45.32 µM -1.24147906452221 0.115220140333123 no 2981 0.107214413686103 4283 2977111
SGTC_2152 5568786 200 µM -1.24213823627708 0.115092114454981 no 2982 0.10709278154601 4324 5399883
SGTC_43 0570-0105 72.5 µM -1.24590048497334 0.114363337834848 no 2983 0.106400466015892 4310 1114046 YDL195W SEC31
SGTC_1113 artemisinin 1.17947 µM -1.24611632053866 0.114321628697437 no 2984 0.106360846974572 4357 2240 An anti-malaria and mitochondrial poison.
SGTC_1848 st056003 16.4 µM -1.24682622435383 0.114184519758502 no 2985 0.106230611305122 4339 146492
SGTC_1776 st049249 45.9 µM -1.24867750264867 0.113827519820602 no 2986 0.105891526296265 4345 1822314
SGTC_384 k007-0144 5.16 µM -1.2513717821254 0.113309378166674 no 2987 0.105399433688627 4258 6824886
SGTC_3017 9080681 49.47 µM -1.25254114167982 0.113085020903216 no 2988 0.105186373330639 4341 16451914
SGTC_940 3232-1287 54.8 µM -1.25338137687741 0.112924006395524 no 2989 0.105033472831913 4328 1585493 YIL048W NEO1
SGTC_1468 k284-1086 134 µM -1.25370164918776 0.112862675619466 no 2990 0.104975234141909 4329 15996457
SGTC_3321 9137793 26.8275 µM -1.25506850661791 0.112601195581464 no 2991 0.104726945962096 4290 4904192
SGTC_2047 4141938 200 µM -1.25802199155506 0.112037671648406 no 2992 0.104191901536235 4341 3807862
SGTC_348 k064-0012 10.7 µM -1.2589578135795 0.111859538474171 no 2993 0.10402278494192 4260 5066323
SGTC_3034 9090421 49.47 µM -1.25963643416906 0.111730490199091 no 2994 0.103900272934118 4241 17173761
SGTC_555 4296-0685 37 µM -1.26053280726374 0.111560196819842 no 2995 0.10373861031147 4312 2908540 YHR072W ERG7
SGTC_2568 diosmetin 100 µM -1.26467052600915 0.110776518381422 no 2996 0.10299472989332 4370 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2909 7941780 10.49 µM -1.26547500668695 0.110624609949331 no 2997 0.102850551138969 4313 1243215
SGTC_1090 efavirenz 20.7 µM -1.26602357480101 0.110521110611526 no 2998 0.102752321077322 4359 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3320 9137005 35.139 µM -1.26816646841566 0.110117472229676 no 2999 0.102369254411276 4383 4908713
SGTC_1481 3346-2004 36 µM -1.26964815519924 0.109838998759291 no 3000 0.102104993986069 4422 2770522
SGTC_3340 9146634 11.102 µM -1.27519237314482 0.108801483448723 no 3001 0.101120580077511 4341 4907387
SGTC_1518 st038567 90.8 µM -1.27580703835259 0.108686893667229 no 3002 0.101011869459739 4294 77966
SGTC_1771 st048882 4.1505 µM -1.28255583991503 0.107434444216641 no 3003 0.099823864922627 4383 4580403
SGTC_2242 6630449 61.2675 µM -1.2872436999495 0.106570610538709 no 3004 0.0990046800171697 4398 691249 YDR170C SEC7
SGTC_3348 9149464 3.537 µM -1.29078808001143 0.105920822897765 no 3005 0.0983885861228877 4298 1951442
SGTC_1515 3460-0031 42.1 µM -1.29142722926476 0.105803953670223 no 3006 0.0982777868745211 4311 2876596
SGTC_1096 rimcazole 32.2 µM -1.29201186997682 0.105697133047264 no 3007 0.0981765169704558 4283 18528119 A dopamine reuptake inhibitor.
SGTC_221 trifluoperazine 10.304 µM -1.29343611791532 0.105437232856366 no 3008 0.097930132537386 4345 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_813 k007-0158 173 µM -1.29449797866303 0.105243762960854 no 3009 0.0977467335189133 4363 6523916
SGTC_182 3448-4371 550.524 µM -1.29571310150391 0.105022684179219 no 3010 0.0975371729555704 4249 3491403
SGTC_1590 st077108 57.8 µM -1.29600331250106 0.104969933115286 no 3011 0.0974871718329468 4380 5489485
SGTC_2475 5812728 15.03 µM -1.29749789359031 0.104698569875343 no 3012 0.097229964704982 4324 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2830 7992007 71.43 µM -1.29809265446372 0.104590723708256 no 3013 0.0971277490729302 4237 1952075
SGTC_1429 4049-0205 9.46 µM -1.30149150609645 0.103975964035987 no 3014 0.0965451350165869 4401 22774478
SGTC_893 0958-0369 48.9 µM -1.30224178591819 0.103840612625961 no 3015 0.0964168724667558 4272 6819948
SGTC_2688 kanamycin b 96.69 µM -1.30427122977687 0.103475138916894 no 3016 0.0960705605379376 4377 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3160 9100216 49.47 µM -1.30715767770561 0.102956940638845 no 3017 0.0955795829264859 4352 17191039
SGTC_1058 3448-5425 97.3 µM -1.30811935722928 0.102784711611732 no 3018 0.0954164144104211 4321 7279705
SGTC_3046 9092212 49.47 µM -1.30889467096526 0.102646011700635 no 3019 0.0952850160077528 4447 25236637
SGTC_622 1348-1566 26.3 µM -1.31116306741276 0.102240987841786 no 3020 0.0949013385478962 4357 7340407
SGTC_2214 7179297 48.276 µM -1.31434476618042 0.101674853729784 no 3021 0.0943651044123903 4446 769744
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.31598995472261 0.1013830146727 no 3022 0.0940887071387493 4292 6708630 An antioxidant.
SGTC_1973 st070275 50.2 µM -1.31630686367774 0.10132686853751 no 3023 0.0940355340362067 4320 17118334
SGTC_2356 9061756 188.97 µM -1.31769113108274 0.101081886185076 no 3024 0.0938035323418027 4413 20104043
SGTC_45 0kpi-0036 14.9 µM -1.32157188389927 0.100397387568532 no 3025 0.0931553754960738 4377 2795021
SGTC_1074 carmofur 3.8 µM -1.32414388825133 0.0999455974400256 no 3026 0.0927276310376213 4428 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1094 duloxetine 25.4 µM -1.32427091744181 0.099923322434117 no 3027 0.0927065427931579 4403 60834 A selective serotonin reuptake inhibitor.
SGTC_2715 st079500 56.4 µM -1.32714933746218 0.0994195530795277 no 3028 0.092229643722855 4359 28246688
SGTC_1403 3909-7815 62.9 µM -1.32760063298262 0.0993407378291471 no 3029 0.092155037667236 4355 6615483
SGTC_1903 st060211 78.3 µM -1.32820356084952 0.0992355124613799 no 3030 0.0920554341921192 4406 688960
SGTC_3181 9108277 49.47 µM -1.32999848931579 0.0989227369169211 no 3031 0.0917593845202175 4347 17097298
SGTC_71 0417-1750 47.813 µM -1.33000235877069 0.0989220634244307 no 3032 0.0917587470676779 4364 6811472
SGTC_112 phenothiazine 287.218 µM -1.33106105084799 0.0987379202740374 no 3033 0.0915844617470601 4346 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2150 5556613 200 µM -1.33313602844134 0.0983777378501123 no 3034 0.0912435839726244 4425 743190
SGTC_2644 guaiazulene 100 µM -1.33370505211554 0.0982791328948764 no 3035 0.0911502692075934 4405 3515 A coloring agent.
SGTC_2786 7743617 45.45 µM -1.33461499465488 0.0981216012701599 no 3036 0.0910011939200816 4326 583674
SGTC_3326 9140064 16.379 µM -1.33621641863442 0.0978448079988283 no 3037 0.0907392730343367 4342 1868434
SGTC_2656 pseudo-anisatin 100 µM -1.33969294599413 0.0972458888761382 no 3038 0.0901725959144056 4444 6708809 A neurotoxin.
SGTC_798 1287-0182 476 µM -1.34066425441623 0.0970790383787576 no 3039 0.0900147426004381 4430 1649755
SGTC_880 0833-0487 87.2 µM -1.34202959062499 0.0968448575393272 no 3040 0.089793200701925 4392 76075
SGTC_1265 0819-1001 68.8 µM -1.34424868949994 0.0964651257343586 no 3041 0.0894339908594125 4345 3106768
SGTC_2093 5331342 194.4 µM -1.34795884174842 0.0958326906314135 no 3042 0.0888358104175457 4445 33839
SGTC_640 3381-0960 37.1 µM -1.35026575816325 0.0954409928912097 no 3043 0.0884653759045328 4455 1745025
SGTC_1801 st050089 28.441 µM -1.35273871143387 0.0950224133838055 no 3044 0.0880695593318716 4441 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2967 9089538 49.85 µM -1.35283002421204 0.0950069834370466 no 3045 0.0880549692871153 4396 728216
SGTC_2179 6298986 200 µM -1.35297923126332 0.0949817745428801 no 3046 0.0880311327172844 4378 738374
SGTC_62 0180-0423 3.232 µM -1.3542656575805 0.0947646340399574 no 3047 0.0878258192295843 4370 30102 YGL099W LSG1
SGTC_2872 9044037 25.97 µM -1.3612604453496 0.0935903582733695 no 3048 0.0867156991361705 4462 6465195
SGTC_2206 7254556 146.969 µM -1.36299323993106 0.0933011266822791 no 3049 0.0864423205614168 4446 4398905
SGTC_1361 1608-0041 5.61 µM -1.36822030647017 0.0924326455479296 no 3050 0.0856215636063296 4392 X1361
SGTC_1145 3546-0597 10.2 µM -1.36842505283371 0.0923987489369213 no 3051 0.0855895333824724 4374 875334
SGTC_715 0868-0130 184 µM -1.37185958428444 0.0918315185554547 no 3052 0.0850535770425756 4466 2876258
SGTC_3222 9128301 49.47 µM -1.37228631907051 0.0917612216670764 no 3053 0.0849871614344173 4388 4911358
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.37328772689141 0.0915964142730846 no 3054 0.0848314582535091 4386 756377
SGTC_2249 haloperidol 116.36 µM -1.37587133783208 0.0911722277991877 no 3055 0.0844307351965869 4372 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2889 9059656 51.95 µM -1.37712105452599 0.090967568348812 no 3056 0.0842374121133528 4488 3949838
SGTC_1141 3253-0389 52.6 µM -1.37826269614874 0.0907809058238774 no 3057 0.0840610980969478 4409 5402031
SGTC_2397 5161689 200 µM -1.37861362926404 0.0907235841459363 no 3058 0.0840069560420988 4463 2259942
SGTC_518 1021-0119 62.6 µM -1.37963770224045 0.0905564648659385 no 3059 0.0838491114784661 4391 1097762
SGTC_1301 naphtanilide LB 4.81 µM -1.38483333218538 0.0897121056281436 no 3060 0.0830517180972191 4481 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_340 k038-0059 454 µM -1.38608999840207 0.0895087624356176 no 3061 0.0828597119961359 4396 23733424
SGTC_783 0848-0141 92.7 µM -1.3866641872569 0.0894159661808032 no 3062 0.0827720928869723 4349 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2469 5655019 90.81 µM -1.38770113747237 0.0892485631178856 no 3063 0.0826140347631499 4478 2788239
SGTC_229 benomyl 22.8748 µM -1.38809314725852 0.089185338659958 no 3064 0.0825543415078188 4443 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1026 k007-1105 30.6 µM -1.38928781228763 0.0889928652297204 no 3065 0.0823726242387742 4390 7066794
SGTC_74 000s-0487 160.283 µM -1.39121437510405 0.0886831267967543 no 3066 0.0820802147059555 4300 677548
SGTC_888 0916-0002 6.97 µM -1.39287690689139 0.0884164833007107 no 3067 0.0818285084053471 4451 2802138 YIL048W NEO1
SGTC_1098 clofazimine 15.1 µM -1.39775389086384 0.0876377399608583 no 3068 0.0810934924967032 4485 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_821 1114-0266 29.2 µM -1.40039801370984 0.0872176789468649 no 3069 0.0806970822515423 4462 3123235
SGTC_3201 9113999 49.47 µM -1.40185039756082 0.0869875852681715 no 3070 0.0804799626084484 4410 16649224
SGTC_2882 9058044 58.44 µM -1.40695774585613 0.0861820548842519 no 3071 0.0797199593283308 4458 18076804
SGTC_3057 9095946 49.47 µM -1.41367177010497 0.0851316255778519 no 3072 0.0787291488677345 4500 24540043
SGTC_146 3448-8650 53.125 µM -1.41926940006473 0.0842632178611068 no 3073 0.0779102448462047 4429 2891488 YIL048W NEO1
SGTC_219 mitoxanthrone 164.414 µM -1.41944035777672 0.0842368007598111 no 3074 0.0778853367335577 4390 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1340 1486-1359 257 µM -1.42006393594467 0.0841404955375157 no 3075 0.0777945341688531 4392 4309068
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.42012965630878 0.0841303505208919 no 3076 0.0777849689561024 4417 16623 A steroid.
SGTC_1232 0279-0259 161 µM -1.42451963423334 0.0834547627536826 no 3077 0.0771480527722047 4441 1560000
SGTC_344 k064-0035 6.43 µM -1.43023253822503 0.082581701676517 no 3078 0.076325144791264 4403 5088750
SGTC_1154 4088-0362 150 µM -1.43226957481001 0.0822720647664992 no 3079 0.0760333434504745 4458 6618304
SGTC_560 2332-1943 155 µM -1.43671750685458 0.0815990031583495 no 3080 0.0753991392169398 4455 21177716
SGTC_639 0833-0042 114 µM -1.43794653682147 0.0814137602877028 no 3081 0.0752246120601569 4484 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_887 0885-0007 9.62 µM -1.43972024988646 0.0811469806667786 no 3082 0.0749732809471002 4485 5719458
SGTC_289 k017-0060 526 µM -1.44700534874082 0.0800581633101714 no 3083 0.0739477127616726 4453 5512909
SGTC_2584 androsterone 48.74 µM -1.448418724565 0.0798482080224251 no 3084 0.0737499906020806 4364 2754130 A steroid.
SGTC_954 1189-0853 2.85 µM -1.4497828331704 0.0796459664844623 no 3085 0.0735595440713908 4385 2828194
SGTC_1460 k062-0059 9.15 µM -1.45072543734383 0.0795064434030735 no 3086 0.0734281646581563 4358 1373085
SGTC_2523 spermine 47.74 µM -1.45523715484422 0.0788411849895887 no 3087 0.0728018090547939 4483 1103 A DNA binding polyamine.
SGTC_1452 4194-0072 190 µM -1.4559616322909 0.0787347539970787 no 3088 0.0727016131491705 4520 1343545
SGTC_2719 novobiocin 32.65 µM -1.45669172916674 0.0786276076471484 no 3089 0.0726007469353465 4507 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2442 5158906 48.48 µM -1.45769135568343 0.0784810853952102 no 3090 0.0724628178548216 4482 1893835
SGTC_1743 st037606 46.3785 µM -1.457952095497 0.0784429009951086 no 3091 0.0724268738464235 4427 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2172 5754775 163.918 µM -1.45979132960129 0.0781739518253781 no 3092 0.07217371609818 4463 2263357
SGTC_2987 9018338 71.43 µM -1.46077553947433 0.078030319479929 no 3093 0.0720385253382134 4488 5055682
SGTC_1850 st056238 17 µM -1.46080484301429 0.078026046089314 no 3094 0.0720345031913661 4478 5393177
SGTC_125 0133-0007 11.75 µM -1.46189578356792 0.0778670784912837 no 3095 0.0718848853003997 4555 26541
SGTC_3332 9141069 11.198 µM -1.46317548295117 0.0776809190943915 no 3096 0.0717096837938069 4418 17332883
SGTC_54 0159-0055 9 µM -1.46405492896812 0.077553181043678 no 3097 0.0715894703391905 4459 3319099
SGTC_3294 9122953 26.2835 µM -1.46438437396548 0.0775053708001654 no 3098 0.0715444775925714 4454 16459826
SGTC_1893 st059353 36.1 µM -1.47014456607529 0.0766730437063667 no 3099 0.0707613022140808 4475 3112488
SGTC_207 4185-0010 4.486 µM -1.47074214490161 0.0765870863756014 no 3100 0.0706804319772826 4547 3761753
SGTC_3198 9112019 49.47 µM -1.47177698595258 0.0764384054750964 no 3101 0.070540555142438 4525 45595555
SGTC_378 3970-0959 8.33 µM -1.47411016980357 0.0761039908435028 no 3102 0.070225965390962 4496 6615653
SGTC_2801 7907800 81.82 µM -1.4754476001544 0.0759128001307134 no 3103 0.0700461230510241 4466 6620925
SGTC_230 MPP+ 141.667 µM -1.47546709705003 0.075910015683281 no 3104 0.0700435039542183 4446 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1051 3253-3903 78 µM -1.478662619719 0.0754546975659889 no 3105 0.0696152537497134 4456 5509239
SGTC_2125 5246583 200 µM -1.48184874894209 0.0750027930224695 no 3106 0.0691902722769646 4483 835267
SGTC_2117 5521686 200 µM -1.48197353876645 0.0749851355612232 no 3107 0.0691736679708629 4468 803312
SGTC_921 1561-0023 372 µM -1.48573426197506 0.074454488544575 no 3108 0.0686747121598218 4464 24050882
SGTC_1745 st081495 74 µM -1.48695951923727 0.0742822224250598 no 3109 0.0685127513949546 4348 13842402 YBL026W LSM2
SGTC_1152 3909-8331 15.9 µM -1.49013411451893 0.0738373034565487 no 3110 0.0680944879031233 4470 16001939
SGTC_2997 9067075 71.4286 µM -1.49904285073258 0.0725996222542239 no 3111 0.0669312579559983 4455 27209819
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.50003213583504 0.0724631680233331 no 3112 0.0668030392130838 4489 688751
SGTC_2902 5787006 60.46 µM -1.50362491915832 0.0719692597661629 no 3113 0.0663389855683943 4467 591003
SGTC_990 3985-0011 41.3 µM -1.50910279900499 0.0712211764806807 no 3114 0.0656362571975728 4467 5399565 YGL099W LSG1
SGTC_2215 7188065 200 µM -1.50954343365808 0.0711612618765882 no 3115 0.0655799822517857 4556 940217
SGTC_2145 5634607 200 µM -1.51543049789622 0.0703644856210903 no 3116 0.0648317094376947 4506 308662
SGTC_475 α-linolenic acid 10 µM -1.51613082791207 0.070270158828042 no 3117 0.0647431372712782 4494 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3148 9097893 49.47 µM -1.51716373674405 0.0701312148243432 no 3118 0.0646126747170592 4475 17174100
SGTC_143 4032-1194 15.74 µM -1.51757649355153 0.0700757510684314 no 3119 0.0645605982052283 4536 1806963
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.51855331985427 0.0699446255059982 no 3120 0.0644374843181647 4552 165506
SGTC_2016 5121758 140 µM -1.51893627763615 0.0698932702129095 no 3121 0.0643892682010109 4433 2795203
SGTC_3285 9112818 20.8695 µM -1.51973027186509 0.0697868866821449 no 3122 0.0642893900558894 4485 17017947 YPR165W RHO1
SGTC_1390 3413-2614 145 µM -1.52105038922272 0.0696102863286663 no 3123 0.0641235963794382 4491 3421432
SGTC_1114 scopoletin 1.73284 µM -1.52533147094313 0.0690399459660583 no 3124 0.0635882209890013 4535 5280460 A coumarin with genotoxic properties.
SGTC_1631 benzylvanillin 81.9 µM -1.52915571141004 0.0685335191468995 no 3125 0.0631129234807345 4534 75506
SGTC_2880 9042983 58.44 µM -1.5297112304303 0.0684601932530926 no 3126 0.06304411128716 4465 6464714
SGTC_673 1082-0474 110 µM -1.52972311862731 0.0684586247288315 no 3127 0.0630426393339851 4497 3098046
SGTC_2536 dehydroabietamide 32.04 µM -1.5303033048324 0.0683821088670303 no 3128 0.0629708353209132 4544 3983547
SGTC_1719 st032227 49.2 µM -1.53053014115735 0.0683522112877969 no 3129 0.0629427793207515 4500 3125804
SGTC_2183 6420625 130.508 µM -1.53053558457585 0.0683514939559481 no 3130 0.0629421061772137 4543 2897619
SGTC_975 1335-0046 28.5 µM -1.535020110379 0.0677624959577927 no 3131 0.0623894441390848 4502 16486740
SGTC_2217 6934799 96.0675 µM -1.54399027736425 0.06659612585699 no 3132 0.0612953440039011 4493 675606
SGTC_1665 st014639 11.4 µM -1.5459473356022 0.0663437311878715 no 3133 0.0610586436273468 4607 981133 YIL048W NEO1
SGTC_135 0933-0004 26.348 µM -1.54652712568072 0.066269100176983 no 3134 0.0609886570967136 4452 21230617 YGL099W LSG1
SGTC_467 ro 31-8220 72.8 µM -1.55015210491869 0.0658039633159923 no 3135 0.0605525061944679 4497 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_960 1222-0186 7.7 µM -1.55137995758614 0.0656469872180792 no 3136 0.0604053277090058 4511 3126296
SGTC_617 3770-0098 35 µM -1.55270204336254 0.0654782885612433 no 3137 0.0602471669721242 4446 5962639
SGTC_2716 st080858 38.6235 µM -1.55635597883544 0.0650137934948037 no 3138 0.0598117334623067 4514 5296050
SGTC_335 4077-0256 27.6 µM -1.55646627552254 0.0649998122443345 no 3139 0.0597986280203619 4456 3121989
SGTC_516 3992-2719 87.3 µM -1.5593168416938 0.0646392823507466 no 3140 0.0594607037541651 4422 5350887 YDR037W KRS1
SGTC_2868 9035608 32.47 µM -1.56008599540494 0.0645422689797152 no 3141 0.0593697802919028 4518 6462614
SGTC_198 3454-2873 16.191 µM -1.56361972234429 0.0640980128024983 no 3142 0.058953450205532 4531 710957
SGTC_964 1287-0107 19.4 µM -1.56458476302792 0.0639771031775766 no 3143 0.0588401519388097 4519 51516812 YPR165W RHO1
SGTC_2162 5663267 200 µM -1.56529376386195 0.0638883857673968 no 3144 0.0587570223458682 4537 6456493
SGTC_2110 5483698 200 µM -1.56650619116942 0.0637368962456276 no 3145 0.0586150801569581 4507 2848765 YHR062C RPP1
SGTC_610 4215-0184 155 µM -1.56843351195245 0.0634966580579525 no 3146 0.0583899976693388 4540 5605015
SGTC_2109 5483026 200 µM -1.56872430285726 0.0634604725909579 no 3147 0.0583560966173407 4546 759335
SGTC_3070 9117005 49.47 µM -1.57097310985431 0.0631811770808755 no 3148 0.0580944474825701 4628 8779016
SGTC_1612 st002233 45.4 µM -1.57245916564783 0.0629971390067912 no 3149 0.0579220510674692 4557 1035021
SGTC_2099 5377090 177.372 µM -1.57281417578874 0.062953235228648 no 3150 0.0578809261262198 4529 2243829
SGTC_564 3555-0129 330 µM -1.57684166447422 0.0624568269161332 no 3151 0.0574159810495875 4440 563260
SGTC_872 0588-0139 234 µM -1.57737529337865 0.0623912840736469 no 3152 0.0573545984396568 4487 2047100
SGTC_305 1682-2595 20.8 µM -1.57907467396018 0.0621829153902341 no 3153 0.0571594649871175 4545 226033
SGTC_3302 9125395 16.351 µM -1.58064557816083 0.0619907829829956 no 3154 0.0569795491323288 4495 17599668
SGTC_257 daunorubicin 18.5 µM -1.58274068907391 0.0617352577786319 no 3155 0.056740290064721 4562 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2417 cerulenin 830 nM -1.58490503437734 0.0614721528220237 no 3156 0.0564939562646528 4539 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1321 1326-2144 215 µM -1.58873257898854 0.0610090087345925 no 3157 0.0560603901866426 4510 3513030
SGTC_2241 6772625 37.8075 µM -1.59079682131242 0.0607603640705342 no 3158 0.0558276542802566 4344 2285411
SGTC_1625 st003711 30.1 µM -1.59202708089623 0.0606125526611762 no 3159 0.0556893099071131 4547 24207034 YER133W GLC7
SGTC_2065 5221596 34.26 µM -1.59223560579062 0.060587527022677 no 3160 0.0556658878358541 4508 788581
SGTC_1002 4049-0206 172 µM -1.59272135761364 0.0605292619739164 no 3161 0.055611357047515 4507 4662749
SGTC_858 0438-0351 2.77 µM -1.59547542728112 0.0601997447900099 no 3162 0.0553029803476226 4529 2799119
SGTC_2480 5767542 37.17 µM -1.60008394622858 0.0596514906064466 no 3163 0.0547899809391233 4478 2867358
SGTC_1407 3909-7909 12.3 µM -1.60526577124819 0.0590397142086326 no 3164 0.0542176642652222 4570 4411780
SGTC_2460 5552655 174.22 µM -1.60769780683372 0.0587542856488907 no 3165 0.0539506895745798 4529 5401989
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.61304346722953 0.0581307152644242 no 3166 0.0533675322873744 4568 390807
SGTC_3295 9122362 53.5725 µM -1.61394299980182 0.0580262979525993 no 3167 0.0532698952817219 4532 4730473
SGTC_1505 k297-0037 20.6 µM -1.61982018350339 0.0573477006434289 no 3168 0.052635454651583 4550 4089396
SGTC_2804 7954240 19.48 µM -1.62137295058521 0.0571694603340888 no 3169 0.0524688391376892 4564 828705
SGTC_851 0394-0702 453 µM -1.62274214895918 0.0570126536805638 no 3170 0.0523222685754666 4567 762646
SGTC_2305 7443522 69.23 µM -1.62528924945105 0.0567218495460168 no 3171 0.0520504705212013 4455 5415886
SGTC_2546 rhodinyl acetate 100 µM -1.62731707563916 0.0564911677477947 no 3172 0.0518348865663517 4518 6708682
SGTC_2794 7785382 27.27 µM -1.62813387083961 0.0563984597510159 no 3173 0.0517482514880021 4546 2205081
SGTC_61 0978-8327 98.565 µM -1.62934976699208 0.0562606751168231 no 3174 0.0516194981751357 4493 6150059 YHR072W ERG7
SGTC_2092 5303694 80.6725 µM -1.63069206172704 0.0561088754131264 no 3175 0.0514776562239875 4574 1963699
SGTC_3284 9108171 64.8615 µM -1.63948024208023 0.055122988145029 no 3176 0.0505566411104879 4544 8687505
SGTC_1315 1237-0019 3.69 µM -1.64132926441689 0.054917311645838 no 3177 0.050364542249181 4573 825140
SGTC_1843 st055809 45.5 µM -1.64368971279567 0.0546556283959835 no 3178 0.0501201559854045 4591 16413835
SGTC_136 0097-0015 404.482 µM -1.64676798191893 0.054315848699035 no 3179 0.0498028724188898 4557 4861337
SGTC_698 k064-0052 127 µM -1.6470810460114 0.0542813864783893 no 3180 0.0497706942179357 4646 5088751
SGTC_2297 7971671 152.32 µM -1.65033696655188 0.0539239981743069 no 3181 0.049437017753268 4557 909016
SGTC_3336 9143619 71.43 µM -1.65114798441618 0.0538352667006423 no 3182 0.0493541806361547 4573 45595730
SGTC_277 nystatin 15.5 µM -1.65326883497356 0.0536037760840107 no 3183 0.0491380813478886 4596 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1471 k673-0312 37 µM -1.65762232895191 0.0531310636883501 no 3184 0.0486968599352412 4555 24099884
SGTC_1627 st003713 25.6 µM -1.65775337356173 0.0531168859709462 no 3185 0.0486836279799396 4573 16195070 YER133W GLC7
SGTC_1263 0774-1208 64.8 µM -1.65872396126321 0.0530119714435024 no 3186 0.0485857143696474 4562 906585
SGTC_601 0986-0029 62.9 µM -1.65987201953201 0.052888085674567 no 3187 0.0484701007247175 4537 24747981
SGTC_1902 st060212 70.5 µM -1.66109727016597 0.0527561236002357 no 3188 0.04834695632478 4563 688944
SGTC_579 4491-1009 110 µM -1.66118822928848 0.052746337537052 no 3189 0.0483378244222759 4629 1271041
SGTC_2405 ticlatone 3.52 µM -1.66299570003285 0.05255217481459 no 3190 0.0481566481159196 4387 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2192 5915882 198.485 µM -1.66378638395532 0.0524674162571941 no 3191 0.0480775629810241 4569 2876149
SGTC_2000 st075254 36.4 µM -1.66534089625069 0.0523010943882909 no 3192 0.0479223818955905 4460 17234175
SGTC_2653 dihydrofissinolide 100 µM -1.66550894985838 0.0522831389403799 no 3193 0.0479056297825232 4645 6857746
SGTC_2054 5233173 129 µM -1.66712271042531 0.0521109680798145 no 3194 0.0477450035824522 4567 6889
SGTC_274 sirtinol 40.1 µM -1.67985502482032 0.0507683130294686 no 3195 0.0464927630958002 4618 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_547 1120-0019 610 nM -1.6815449491144 0.0505921957763246 no 3196 0.0463285566468289 4554 3676939
SGTC_1933 st074711 15.9 µM -1.68446428756368 0.0502891006580674 no 3197 0.0460459878199221 4576 17250958
SGTC_1438 4092-1045 4 µM -1.69291906507908 0.0494194577235165 no 3198 0.0452354369197843 4615 1351342
SGTC_288 1315-0019 35.1 µM -1.69443089224641 0.0492652267061277 no 3199 0.0450917167101378 4622 6811474
SGTC_1342 1486-1464 234 µM -1.69779822942107 0.0489230847978898 no 3200 0.0447729251072282 4604 3253938
SGTC_380 3970-0968 6 µM -1.70235538311931 0.0484630766071233 no 3201 0.0443443842651771 4490 2891601
SGTC_1081 sertraline 6 µM -1.70435855862561 0.0482619695049114 no 3202 0.0441570605433112 4581 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_969 1313-0238 134 µM -1.70546544398257 0.0481511313922586 no 3203 0.0440538259025038 4615 5212874
SGTC_2770 toltrazuril 17.5 µM -1.71962978533252 0.0467506879875198 no 3204 0.0427498791984566 4531 68591 Kills coccidiodes.
SGTC_1091 telmisartan 47.6 µM -1.72753125216464 0.0459837745381324 no 3205 0.0420361487361757 4626 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2798 7813637 45.45 µM -1.72875429012353 0.0458659753730724 no 3206 0.0419265401135945 4591 956368
SGTC_675 1309-0189 238 µM -1.72941176439505 0.0458027498123439 no 3207 0.0418677129874468 4606 4246530
SGTC_1847 st056231 15 µM -1.73058126392062 0.0456904588189758 no 3208 0.041763237884759 4577 5393180
SGTC_1779 st039427 55 µM -1.7378007338461 0.0450021632240644 no 3209 0.0411229656660545 4595 1124498
SGTC_847 0342-0274 5.54 µM -1.737910587955 0.0449917546860747 no 3210 0.041113284875939 4603 18097
SGTC_1185 1319-0113 81.3 µM -1.74422358350416 0.0443968543318638 no 3211 0.0405600552706555 4641 4672763
SGTC_3258 9138477 49.47 µM -1.74453323042548 0.0443678388472216 no 3212 0.0405330760720651 4638 4970355
SGTC_3186 9110464 49.47 µM -1.74767400997554 0.0440743946927211 no 3213 0.0402602458525646 4598 17018021
SGTC_868 0527-0199 213 µM -1.74906885369486 0.0439445767245791 no 3214 0.0401395591490593 4600 2849450
SGTC_3130 9127414 49.47 µM -1.75465561843971 0.0434277051603377 no 3215 0.0396591158816937 4635 1494646
SGTC_3032 9089427 49.47 µM -1.75933224345056 0.0429988206701653 no 3216 0.0392605465322861 4585 17173707
SGTC_237 nikkomycin 200 µM -1.76065591389995 0.0428780526908672 no 3217 0.0391483293813655 4632 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2731 amoxapine 43.43 µM -1.76280586764077 0.0426824812643841 no 3218 0.0389666187269273 4741 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2382 9035899 200 µM -1.77189086637954 0.0418640087702048 no 3219 0.0382063374344695 4610 6462679
SGTC_1672 st016598 6.51 µM -1.78052508031019 0.0410979710725795 no 3220 0.0374950342692417 4588 4665860 YNL267W PIK1
SGTC_3351 9150312 21.596 µM -1.78487557978288 0.0407163182552918 no 3221 0.037140750255615 4539 4904905
SGTC_1811 st050069 61.5 µM -1.79028406723912 0.04024586786516 no 3222 0.0367041281475463 4618 3877702
SGTC_706 4262-0057 46.9 µM -1.79300937976146 0.0400104883430925 no 3223 0.036485712137462 4615 883298
SGTC_3353 9151644 39.2805 µM -1.79400912224453 0.0399244236335768 no 3224 0.0364058564122815 4627 4909158
SGTC_393 acivicin 6.25 µM -1.79726365598545 0.0396452926556698 no 3225 0.0361468865409767 4502 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2191 5911152 200 µM -1.79794638558333 0.0395869389593098 no 3226 0.0360927522146482 4641 2875902
SGTC_3094 9117742 49.47 µM -1.80113839117815 0.0393150406043541 no 3227 0.0358405349885302 4595 17149698
SGTC_1588 farnesol 29.9 µM -1.81002846282191 0.038565777046492 no 3228 0.0351456866936755 4650 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1641 st009299 47.1 µM -1.81576849314024 0.0380882138504491 no 3229 0.0347029461441859 4578 4046054
SGTC_667 1498-1044 59 µM -1.816387554573 0.0380369981551915 no 3230 0.0346554714734067 4626 6739982
SGTC_3022 9087993 49.47 µM -1.82105825507417 0.0376523939030786 no 3231 0.0342990010039195 4701 17173644
SGTC_3040 9091894 49.47 µM -1.82499328245897 0.0373308373379867 no 3232 0.0340010215286639 4557 25236966
SGTC_2854 9024559 71.43 µM -1.82550512455263 0.0372891767703014 no 3233 0.0339624192876762 4614 3163529
SGTC_1198 1612-1005 86.7 µM -1.8264218347826 0.0372146575447468 no 3234 0.0338933726863305 4676 6998509
SGTC_3234 9132280 49.47 µM -1.82897443772786 0.0370077978160779 no 3235 0.0337017188624673 4650 17612295
SGTC_2663 amphotericin b 100 µM -1.82913067739484 0.0369951669366758 no 3236 0.0336900171406466 4654 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_60 0986-0278 202 µM -1.83155205965505 0.0367998653104197 no 3237 0.0335090924056114 4590 3110598
SGTC_1192 1488-0095 21.4 µM -1.83310521779911 0.03667503654597 no 3238 0.0333934626606039 4663 915875
SGTC_2024 5144227 134 µM -1.83494585021587 0.0365275518750146 no 3239 0.0332568565790449 4606 3475211
SGTC_3170 9103054 49.47 µM -1.83609457779492 0.036435753765033 no 3240 0.0331718350485097 4607 16432970
SGTC_2979 9012552 45.46 µM -1.84787419031061 0.0355052627466743 no 3241 0.0323102725243425 4643 17100905
SGTC_1220 1838-0075 193 µM -1.85095881913951 0.0352648483191196 no 3242 0.0320877388719902 4578 5529645
SGTC_1666 st014829 29 µM -1.85129239816642 0.0352389295376866 no 3243 0.0320637495631028 4666 3858230
SGTC_2981 9013952 38.96 µM -1.85658745567615 0.0348295971567291 no 3244 0.0316849349997154 4570 2996344
SGTC_1802 st050112 57.9 µM -1.85832573810262 0.0346960740603565 no 3245 0.0315613854776505 4662 4662563
SGTC_1522 st012842 45.6 µM -1.8586186945741 0.0346736125719108 no 3246 0.0315406026713933 4490 3491067 YOR116C RPO31
SGTC_997 3996-0078 137 µM -1.86434714340286 0.0342367968969655 no 3247 0.0311364852143188 4680 735687
SGTC_496 calpeptin 138 µM -1.87603482613222 0.0333595927648492 no 3248 0.0303252489545639 4635 73364 A calpain inhibitor.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.89705262091715 0.031828720385611 no 3249 0.028910496734086 4657 23665772 A membrane-active detergent.
SGTC_1806 st050005 60.3 µM -1.89739398102405 0.0318043439206418 no 3250 0.0288879797177589 4693 5194765
SGTC_1230 0170-0365 3.77 µM -1.90121013762879 0.0315328813344295 no 3251 0.0286372468843949 4659 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_801 0866-0028 10.1 µM -1.9027494972486 0.031423922317635 no 3252 0.028536619956989 4689 6849771
SGTC_3028 9087778 49.47 µM -1.91438101185595 0.030610643310929 no 3253 0.0277857449759462 4634 17217395
SGTC_1887 st057648 70.8 µM -1.92540966387255 0.0298556930907797 no 3254 0.0270890637746595 4667 688672
SGTC_1987 st072290 61.9 µM -1.93888355589347 0.028954384130487 no 3255 0.0262577593625404 4676 54697379
SGTC_721 1187-1332 279 µM -1.94542513859836 0.0285250206041531 no 3256 0.0258619158060063 4671 25730
SGTC_313 3474-0040 5.03 µM -1.94856159069392 0.0283210425320038 no 3257 0.0256739014044496 4677 1043375 YIL048W NEO1
SGTC_892 0929-0076 29 µM -1.95359915100554 0.027995967984668 no 3258 0.0253743205618034 4673 5751038
SGTC_139 0099-0334 718.624 µM -1.9598728589124 0.0275954753841383 no 3259 0.0250053263192958 4658 97690
SGTC_561 1550-0330 72.9 µM -1.96422059528924 0.0273207411272357 no 3260 0.0247522577069396 4663 6812934
SGTC_407 eburnamonine 100 µM -1.97750145609154 0.0264956132337407 no 3261 0.0239924880435347 4562 3195
SGTC_970 1315-0089 19.5 µM -1.98190839007803 0.0262264579235286 no 3262 0.0237447473711212 4663 6811083 YLR033W RSC58
SGTC_2438 5259590 200 µM -1.98308949520303 0.0261547111226776 no 3263 0.0236787168924078 4701 1201127
SGTC_3074 9116018 49.47 µM -1.99382461059168 0.0255100958116381 no 3264 0.0230856125238792 4696 17027303
SGTC_1680 diphenhydramine 100 µM -1.99384658537023 0.0255087900544579 no 3265 0.0230844113892464 4626 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1408 3909-7976 48.8 µM -1.99540818544297 0.0254161418604341 no 3266 0.0229991894564097 4710 24152374
SGTC_642 0335-0876 158 µM -1.99898579545976 0.025204947898283 no 3267 0.02280494539541 4726 6812350
SGTC_2876 9059903 25.97 µM -2.00756808903143 0.0247043056949418 no 3268 0.0223446042048714 4681 6916095
SGTC_1935 st074532 41.6 µM -2.03138889750255 0.0233582653090527 no 3269 0.0211077798937739 4669 2829742
SGTC_2788 5282734 71.43 µM -2.03184497523846 0.0233331082164499 no 3270 0.0210846762331326 4686 743706
SGTC_1691 st019933 84.6 µM -2.03338938175008 0.0232480885610837 no 3271 0.0210065996280227 4686 6176082
SGTC_618 k072-0232 33.2 µM -2.04441392212215 0.0226487304553737 no 3272 0.0204563365477781 4706 5872756 YGL099W LSG1
SGTC_2038 4100038 30.985 µM -2.04790042534774 0.0224619161233274 no 3273 0.0202848785950653 4663 3596803
SGTC_1559 coumarin 343 70.1 µM -2.06383221841608 0.0216247106390969 no 3274 0.0195168135841164 4719 108770 A hepatotoxic, DNA x-linker.
SGTC_854 0422-0053 192 µM -2.06682305856533 0.0214705200836166 no 3275 0.0193754149392046 4714 3596728
SGTC_491 tetrandrine 80.3 µM -2.08633807095026 0.0204870867487324 no 3276 0.018474005198251 4715 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3033 9090887 49.47 µM -2.08831329957178 0.0203897092992803 no 3277 0.0183847912691977 4709 19325384
SGTC_3154 9100113 49.47 µM -2.09187802005181 0.0202149636518458 no 3278 0.0182247143828036 4676 25237525
SGTC_923 1900-2434 73.3 µM -2.09457491051201 0.0200836049986112 no 3279 0.0181043987358063 4666 5910570
SGTC_486 niguldipine 82 µM -2.09688809631754 0.0199715131014981 no 3280 0.0180017412623708 4757 1236 A calcium channel blocker.
SGTC_2931 9014674 55.67 µM -2.119807548061 0.0188892864391189 no 3281 0.0170111392522949 4663 2996810
SGTC_1015 4130-4525 82 µM -2.14619251088227 0.0177055891957463 no 3282 0.015928811420862 4710 1363237
SGTC_8 0354-0001 70 µM -2.14688518412 0.0176753866719469 no 3283 0.0159012117072425 4719 4993152
SGTC_97 0535-0701 19.132 µM -2.15330001951101 0.0173977645669469 no 3284 0.0156475536326598 4647 2832013 YGL099W LSG1
SGTC_1193 1488-0126 41.5 µM -2.16376510760646 0.0169528486056768 no 3285 0.0152411906509702 4705 1384710
SGTC_66 0109-0187 42.4 µM -2.16748236284134 0.0167971709127565 no 3286 0.0150990465491163 4567 759417
SGTC_1565 sinapyl alcohol 95.1 µM -2.2006468307383 0.0154615703805979 no 3287 0.0138805177767104 4707 5280507 A phenol propionate derived from cinnamic acid.
SGTC_295 k015-0027 31 µM -2.21486349592654 0.0149175736854752 no 3288 0.0133847176764118 4748 3887424
SGTC_445 e6 berbamine 66 µM -2.21632345473035 0.0148626519188361 no 3289 0.0133346789072744 4719 6610268 A calcium/calmodulin antagonist.
SGTC_1244 0416-0015 52.5 µM -2.22301860670679 0.0146130103685542 no 3290 0.013107272668381 4711 96201
SGTC_535 2293-4129 48.2 µM -2.23068292833136 0.0143316687986567 no 3291 0.0128510696244762 4715 396118 YIL048W NEO1
SGTC_1936 st074407 74.3 µM -2.23322192879775 0.0142395016933094 no 3292 0.0127671564623435 4730 809813
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.23957064882469 0.0140112712739437 no 3293 0.0125594049927328 4698 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2818 7996756 12.99 µM -2.2607941779027 0.0132710488221049 no 3294 0.011886002649894 4723 2241621
SGTC_3249 9135183 49.47 µM -2.26472197172923 0.01313782681559 no 3295 0.0117648731473035 4710 4902779
SGTC_1194 1488-0194 225 µM -2.26565185358291 0.0131064570209693 no 3296 0.0117363537837351 4744 1391452
SGTC_2777 climbazole 1.536 µM -2.27306909167466 0.0128585441500344 no 3297 0.0115110083368048 4534 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2950 9072895 21.46 µM -2.27584866694307 0.012766690273364 no 3298 0.0114275343851264 4674 17332245
SGTC_2499 avocadenofuran 51.48 µM -2.29216033674672 0.0122390142679984 no 3299 0.0109481963779999 4709 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3349 9149703 23.001 µM -2.31401375028812 0.0115617527727545 no 3300 0.0103334839503027 4745 4910494
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -2.31568596066095 0.0115112960454697 no 3301 0.0102877107554425 4745 94937 An inhibitor of serotonin biosynthesis.
SGTC_2612 dictamnine 15.46 µM -2.32043968743458 0.0113689018994662 no 3302 0.0101585520232674 4674 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2862 9027634 71.43 µM -2.32810083601703 0.0111426386176437 no 3303 0.00995337496508286 4719 5012562
SGTC_2760 etidronate 98.04 µM -2.33800783602966 0.0108558594926742 no 3304 0.00969342082587078 4707 3305 A chelator and antioxidant.
SGTC_553 k007-0256 45.7 µM -2.33859301419566 0.0108391230390743 no 3305 0.00967825334909544 4764 6287000
SGTC_2013 4024628 200 µM -2.35497781397181 0.0103795387481311 no 3306 0.00926190581244678 4729 5230760
SGTC_1372 2752-0194 270 µM -2.3576483534025 0.0103062643688437 no 3307 0.0091955525512961 4716 823334
SGTC_2482 5981709 142.65 µM -2.37508016142077 0.00983895852521848 no 3308 0.00877256968778025 4724 877755
SGTC_2064 5220758 200 µM -2.38577341925752 0.00956154714290305 no 3309 0.00852162399297001 4750 788518
SGTC_2842 9000675 19.48 µM -2.39944971712605 0.00921672915161869 no 3310 0.00820986739162709 4704 2989072
SGTC_2122 5258151 111.688 µM -2.41037562061632 0.00894912634937925 no 3311 0.00796805202104822 4750 2173356
SGTC_2301 7769476 200 µM -2.42338776709606 0.0086393269794438 no 3312 0.00768825186927068 4744 977820
SGTC_2809 7964133 12.99 µM -2.42604557943557 0.00857721819175356 no 3313 0.00763217653369776 4729 1253665
SGTC_1895 st058434 18.3 µM -2.43243234479336 0.00842956889277042 no 3314 0.0074988965515046 4753 5393175
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.43478927641209 0.00837564757064776 no 3315 0.00745023215387314 4746 6708561
SGTC_2836 9010338 19.48 µM -2.50150741205655 0.00696979236171767 no 3316 0.00618329268852926 4722 2994051
SGTC_2266 7929956 200 µM -2.53521459534089 0.00634215254107572 no 3317 0.00561892299967643 4744 2967153
SGTC_301 4119-0100 24.5 µM -2.53528123994628 0.00634096284555284 no 3318 0.00561785403074354 4771 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2541 muurolladie-3-one 83.07 µM -2.5358139240667 0.00633146081746044 no 3319 0.00560931635026186 4745 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.54911740113753 0.00609820579849988 no 3320 0.00539979688431661 4777 688788
SGTC_2948 9070189 9.45 µM -2.59448490752927 0.00535898955321111 no 3321 0.00473663863336883 4717 6473636 YDL196W YDL196W
SGTC_1849 st056239 19.2 µM -2.61671582863804 0.00502673263995247 no 3322 0.0044390109041304 4759 5393181
SGTC_264 promethazine 12.5 mM -2.65068009863025 0.00455448043096572 no 3323 0.00401649433894824 4711 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2896 9052656 71.43 µM -2.6554036690049 0.00449204011530285 no 3324 0.00396067771808232 4461 6469436
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.70960845862736 0.00382834516701276 no 3325 0.00336813385062492 4785 16486 A toxic proline analog.
SGTC_3337 9144342 33.5465 µM -2.72960249124659 0.00360665673518242 no 3326 0.00317053673815914 4769 17682949
SGTC_312 4092-0653 6.84 µM -2.75503983448728 0.00334129838164711 no 3327 0.00293424950681341 4714 1148278
SGTC_1754 st042065 16.137 µM -2.76614855841862 0.00323102325062319 no 3328 0.00283613439797668 4657 1126236 YIL048W NEO1
SGTC_2734 clemastine 41.6 µM -2.83800065032282 0.00259343741798949 no 3329 0.00226985450719226 4808 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1803 st050068 52.4 µM -2.84465988284868 0.00254052566806493 no 3330 0.00222294336528285 4776 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2855 9016525 58.44 µM -2.86292687360618 0.00240035561955251 no 3331 0.00209873712715093 4757 43811474
SGTC_77 0828-0286 12.516 µM -2.90615715724225 0.00209609632628737 no 3332 0.00182948812468182 4736 745345
SGTC_1331 1472-0049 76.2 µM -2.97859395541698 0.00166377913394254 no 3333 0.00144787117383835 4788 24051409
SGTC_1908 st060353 56.5 µM -2.99061531575274 0.00160045504231742 no 3334 0.00139207992416332 4776 4227716
SGTC_304 1310-0298 97 µM -3.05031268138597 0.00131732839908319 no 3335 0.00114301615719913 4663 1550234
SGTC_2328 6201408 200 µM -3.17430261336755 0.000869939749482479 yes 3336 0.000750985045202776 4765 2890418
SGTC_1916 st067606 49.2 µM -3.18067641937348 0.000851250739710829 yes 3337 0.000734658225920131 4759 19590279
SGTC_1912 st060209 90.8 µM -3.27204082698671 0.000620940373833729 yes 3338 0.000533870780457878 4786 688787
SGTC_3043 9092303 49.47 µM -3.36359554025552 0.000449112162036924 yes 3339 0.000384671009922677 4797 25236084
SGTC_3126 9127922 49.47 µM -3.45396750738433 0.000323689543997251 yes 3340 0.000276201963502028 4774 45595682
SGTC_338 4055-0136 114 µM -3.48007302031794 0.000294051698185913 yes 3341 0.000250638569581182 4798 2900563
SGTC_953 1188-0045 9.7 µM -3.48209852106268 0.000291861093131112 yes 3342 0.00024875030815346 4784 6144426
SGTC_1909 st060837 51.5 µM -3.48630382121325 0.000287361438745558 yes 3343 0.000244872222188462 4790 678937
SGTC_2021 4019055 173 µM -3.62204601544974 0.00017247804904997 yes 3344 0.00014614105627716 4752 44827708 YER133W GLC7
SGTC_2728 chlorpromazine 9.18 µM -3.62783640480174 0.000168697671852624 yes 3345 0.000142903127521808 4808 2726 A thorazine and dopamine antagonist.
SGTC_2941 9056145 11.23 µM -3.64049509049108 0.000160701534031611 yes 3346 0.000136057148315671 4797 2119517
SGTC_1375 2910-0797 186 µM -3.77535842159997 9.48977846190711e-05 yes 3347 7.98888770983425e-05 4805 742508
SGTC_1822 st052468 42 µM -3.80431878890203 8.4558293543972e-05 yes 3348 7.10974805005941e-05 4809 2873678
SGTC_1462 k081-0014 26.5 µM -3.92091558012884 5.27173810896491e-05 yes 3349 4.41065823095599e-05 4529 3270634
SGTC_1800 st050079 29.0735 µM -3.96633940294506 4.37011508163605e-05 yes 3350 3.64924564984967e-05 4782 3645560
SGTC_924 2046-0044 21.3 µM -4.04690613831665 3.11825073190101e-05 yes 3351 2.59495197985625e-05 4801 3623589
SGTC_2001 4023502 57.655 µM -4.14724324038576 2.03050309776345e-05 yes 3352 1.68251253547654e-05 4805 108941 YCR052W RSC6
SGTC_1818 st052136 56.3 µM -4.23698967022637 1.37222621673696e-05 yes 3353 1.13268276964994e-05 4777 674169
SGTC_3038 9091290 49.47 µM -4.25920426871651 1.24390183416635e-05 yes 3354 1.02577963545369e-05 4806 25236843
SGTC_3037 9091026 49.47 µM -4.59168134204924 2.70450036939877e-06 yes 3355 2.19844678626684e-06 4794 25236398 YIL048W NEO1
SGTC_2944 9067346 25.62 µM -5.99051810207694 1.36871104451322e-09 yes 3356 1.04586795173726e-09 4807 6473075