SGTCid condition conc unit YPL225W|YPL225W.score YPL225W|YPL225W.strain.pval YPL225W|YPL225W.strain.significant YPL225W|YPL225W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1870 st057514 26.5 µM 5.90362534409443 3.42642019239398e-08 yes 1 1.77799609203361e-09 6 5393161 SGTC_819 1013-0258 27.7 µM 5.90203925906692 3.45405312072897e-08 yes 2 1.79517848154955e-09 18 5753198 SGTC_1762 st045503 25.4615 µM 5.52904116264078 2.15947365416881e-07 yes 3 1.60992897243592e-08 8 4645554 SGTC_2498 4'-Methoxychalcone 54.63 µM 4.96851369809507 2.7522288709322e-06 yes 4 3.37340175149654e-07 13 641818 YHR062C RPP1 SGTC_346 4513-0042 7.16 µM 4.80845632417355 5.43698026592086e-06 yes 5 7.60501252613817e-07 20 2827372 SGTC_913 3487-1245 167 µM 4.54557603082116 1.59155365769088e-05 yes 6 2.73926080310522e-06 13 4016153 SGTC_1862 st057513 3.81 µM 4.51613102981776 1.78891551337475e-05 yes 7 3.14898517347492e-06 4 5393163 SGTC_540 1187-0821 17.3 µM 4.30926761277539 3.98913493553291e-05 yes 8 8.18980349253303e-06 9 847520 SGTC_1596 piperlongumine 63 µM 4.10371098196279 8.55990044680234e-05 yes 9 2.03287665089393e-05 15 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2004 4023728 41.89 µM 4.00738319503804 0.000121031988128585 yes 10 3.06976039666621e-05 28 360084 YDR527W RBA50 SGTC_2950 9072895 21.46 µM 4.00348752030696 0.000122720596930419 yes 11 3.120774755383e-05 35 17332245 SGTC_1682 st012968 530 nM 3.82814308737442 0.000226161304588494 yes 12 6.45568457904345e-05 20 24207270 SGTC_3231 9132313 49.47 µM 3.77631404639102 0.000269711734057457 yes 13 7.95831438527669e-05 9 4905967 SGTC_1132 3456-3614 2.5 µM 3.77440118703896 0.000271459567402726 yes 14 8.01962331782453e-05 60 3125502 SGTC_3270 9137563 49.47 µM 3.73831176545118 0.000306478673922704 yes 15 9.26300617996858e-05 10 17015724 SGTC_3173 9105693 49.47 µM 3.71153013117898 0.000335135294160112 yes 16 0.000103005069512193 29 17096658 SGTC_1229 0139-0193 12.2 µM 3.68066453081908 0.00037124378377993 yes 17 0.000116313448336435 17 3090752 SGTC_2340 7987427 183.45 µM 3.6370691118407 0.000428428304784511 yes 18 0.000137878979809747 50 2239331 SGTC_1746 st038117 42 µM 3.54100294330905 0.00058441510540844 yes 19 0.00019930456581018 46 2898218 SGTC_1644 st010134 20.9 µM 3.53036868475678 0.000604584766921554 yes 20 0.000207490477404693 20 3818134 SGTC_1028 k015-0029 4.8 µM 3.51763216310217 0.000629587351369601 yes 21 0.000217707733009806 37 4588309 SGTC_2194 5927483 104.545 µM 3.49478992818468 0.000676833477923393 yes 22 0.000237217506300816 29 760979 SGTC_1370 2001-0092 44.6 µM 3.47942796023588 0.000710424413949965 yes 23 0.000251242723298263 55 790957 SGTC_1564 D-Arginine 115 µM 3.45712172190708 0.000761942196393982 yes 24 0.000272989087484504 48 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_52 0329-0193 875 nM 3.41668579914784 0.000864195131871226 yes 25 0.000316941962124706 57 3739292 SGTC_2628 lathosterol 100 µM 3.37381743386767 0.000986263232316803 yes 26 0.000370667584792415 48 6710616 SGTC_2504 purpurogallin 52.29 µM 3.36916721891819 0.00100041531185142 no 27 0.00037697836476169 39 5281571 An antioxidant. SGTC_217 ketoconazole 989 nM 3.36184904886807 0.00102306466403551 no 28 0.000387112177144694 46 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1604 st002052 72.4 µM 3.35275686532981 0.00105185961193237 no 29 0.000400054795896794 40 6254834 YHR062C RPP1 SGTC_1318 1280-3875 124 µM 3.34066236093987 0.00109131510772856 no 30 0.000417893981294752 49 373245 SGTC_1653 st012112 65 µM 3.31114837139301 0.00119335788108268 no 31 0.000464569649644208 31 720429 SGTC_2552 juarezic acid 87.02 µM 3.30808820551903 0.00120442333052447 no 32 0.000469676092990861 66 1549512 SGTC_382 3229-0966 23.2 µM 3.28526809466486 0.00128994775356094 no 33 0.000509426880016199 47 5722370 SGTC_3300 9124615 50.48 µM 3.27105715387357 0.00134597634994157 no 34 0.00053573126897968 42 24824903 SGTC_2968 9090663 33.37 µM 3.24949714794659 0.00143523556482085 no 35 0.00057804618751556 57 25236811 SGTC_2019 4016004 108 µM 3.24299453575148 0.00146319846151318 no 36 0.000591402398109718 61 45595336 SGTC_3043 9092303 49.47 µM 3.23262871628735 0.00150880361876601 no 37 0.000613284322900399 46 25236084 SGTC_1146 3579-1023 7 µM 3.21306249588088 0.00159843664129401 no 38 0.000656638549659025 43 X1146 SGTC_654 1124-0271 80.9 µM 3.18389643570833 0.00174107684248449 no 39 0.00072653494872811 62 5403748 SGTC_1970 st070122 35.8 µM 3.18046708961827 0.00175858835284103 no 40 0.000735189197875118 55 102928 SGTC_810 3825-7150 143 µM 3.14056201888549 0.00197447210838384 no 41 0.000843120001911646 30 22330411 YGL099W LSG1 SGTC_149 3970-0822 46.1 µM 3.09829169582301 0.00222915888646314 no 42 0.000973198734283045 170 3114250 YBL034C STU1 SGTC_1379 2144-0755 36.5 µM 3.09138416672684 0.00227349948730424 no 43 0.000996128477061463 51 5392327 SGTC_2789 5281112 71.43 µM 3.08795045462527 0.00229583701707179 no 44 0.00100771034562207 81 765948 SGTC_1417 3966-0327 90.4 µM 3.04533798876896 0.00259006700085284 no 45 0.00116209479443539 56 651118 SGTC_1118 chelidonine 707.474 nM 2.9899584329176 0.0030232388253207 no 46 0.00139507706710954 60 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_926 2268-1401 59.4 µM 2.96229934230576 0.00326314256258188 no 47 0.00152675381698348 63 2931578 SGTC_1243 0416-0003 5.65 µM 2.95841304899028 0.0032981887353699 no 48 0.00154613733381586 84 2141977 SGTC_634 1611-4317 11.2 µM 2.94976175944017 0.00337742331712226 no 49 0.0015900952636428 58 2843522 SGTC_905 2-aminofluorene 215 µM 2.94677427940749 0.00340517959719528 no 50 0.00160553752018141 78 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2215 7188065 200 µM 2.91942895403307 0.00366892460103578 no 51 0.00175336658852134 34 940217 SGTC_1629 st005085 44.9 µM 2.90581313611013 0.00380696443503047 no 52 0.00183150064887807 93 24207091 SGTC_1116 jasmonic acid  1.58368 µM 2.88205126813405 0.00405905520155608 no 53 0.00197547721491991 68 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2346 9031566 143.75 µM 2.86536219841962 0.00424493856216807 no 54 0.00208266258632072 66 4771086 SGTC_2915 7971052 15.16 µM 2.86372826107692 0.00426354035870541 no 55 0.00209343512854817 30 5741558 SGTC_1634 st006576 41 µM 2.8637116754499 0.0042637295532641 no 56 0.00209354473620082 74 3915356 SGTC_3200 9114385 49.47 µM 2.86018020294202 0.00430418492220749 no 57 0.002117001716734 97 17018030 YLR208W SEC13 SGTC_42 0133-0086 60.653 µM 2.85567635404443 0.00435627720037397 no 58 0.00214726327258652 77 162923 Model of phenazepam hydroxylation. SGTC_1483 3453-0561 55.9 µM 2.85034843594056 0.00441862776124576 no 59 0.00218356792467081 78 4546991 SGTC_2231 micatex 6.853 µM 2.84245216437612 0.00451250145878878 no 60 0.00223839743486446 57 20737 An antifungal of unknown mechanism. SGTC_1642 st009582 77.7 µM 2.80744771003726 0.00495044057086196 no 61 0.00249678930842172 67 6739311 SGTC_221 trifluoperazine 10.304 µM 2.78282665841516 0.00528076487590387 no 62 0.00269437941331393 309 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_394 menadione 8.33 µM 2.76960276410659 0.00546615441242278 no 63 0.00280623480857725 90 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2474 5321570 43.32 µM 2.75910057958576 0.00561748494071682 no 64 0.00289803464084245 70 2841384 SGTC_1822 st052468 42 µM 2.7404481119505 0.00589544876846837 no 65 0.00306777344866713 57 2873678 SGTC_700 3453-2283 142 µM 2.73117814060611 0.00603807756035833 no 66 0.00315541748078728 105 565664 SGTC_774 k060-0086 136 µM 2.73010208105658 0.00605483046777514 no 67 0.00316573584409717 85 5911235 SGTC_1879 gemcitabine 100 µM 2.70611366175263 0.00643915060548985 no 68 0.00340378707053794 87 60750 A nucleoside analog which inhibits DNA replication. SGTC_3318 9139014 38.6185 µM 2.680945484248 0.00686542317842293 no 69 0.00367072374225539 77 16643984 SGTC_355 1311-2252 105 µM 2.6782847877329 0.00691191251472917 no 70 0.00370001349931755 98 5338538 SGTC_911 3456-4043 236 µM 2.65004063727411 0.00742281095968314 no 71 0.00402410448771375 122 914281 SGTC_3103 9120822 49.47 µM 2.64591451385133 0.00750016759797122 no 72 0.00407352011508118 84 17141819 SGTC_1004 4084-0029 199 µM 2.6390982715064 0.00762951486672333 no 73 0.00415634401402345 91 716894 YLR208W SEC13 SGTC_978 1416-0512 87.4 µM 2.61473290107903 0.00810807857660379 no 74 0.00446486282856246 113 6814003 SGTC_1805 st050013 60.3 µM 2.61427704082362 0.00811727810966099 no 75 0.0044708249698971 62 4037144 SGTC_308 4092-1169 104 µM 2.61211702609504 0.00816099331544889 no 76 0.00449917231990135 144 2268590 YDL196W YDL196W SGTC_89 0302-0250 142.109 µM 2.61203119214665 0.00816273472096908 no 77 0.00450030208585422 100 4203518 YLR208W SEC13 SGTC_2544 sphondin 68.51 µM 2.60827769079204 0.00823920604155178 no 78 0.0045499549538406 95 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2370 9071495 200 µM 2.60168385325448 0.00837506907163824 no 79 0.00463836630097936 128 21791103 SGTC_2310 7668677 200 µM 2.57785681417115 0.00888254664578817 no 80 0.00497075915939533 130 2197143 SGTC_2088 5278280 127.392 µM 2.57672271957387 0.00890735892130124 no 81 0.00498709628884767 132 791502 SGTC_142 0335-0849 62.6745 µM 2.57358340223281 0.00897635943419993 no 82 0.00503256924521438 254 3889043 YPR107C YTH1 SGTC_1273 0849-0096 14.1 µM 2.57318790635 0.00898508534606056 no 83 0.00503832410695488 100 5286025 SGTC_2018 5133068 143 µM 2.57115553149687 0.00903004337382687 no 84 0.00506798973361918 116 785362 SGTC_1254 0550-0035 264 µM 2.56465188493975 0.00917523676249557 no 85 0.00516396830059086 104 15121435 SGTC_1954 st077032 68.9 µM 2.55804115486569 0.00932491108258256 no 86 0.00526318168920615 103 698907 SGTC_2998 9066762 71.4286 µM 2.55096443639462 0.00948749909179297 no 87 0.00537126435048535 133 4945196 SGTC_1620 st003704 16.5 µM 2.54736023128875 0.00957125463657975 no 88 0.00542706618069825 82 2834414 SGTC_2985 9022375 71.43 µM 2.54318494308416 0.00966908861609928 no 89 0.00549235350094999 135 4939335 SGTC_2296 7971656 126.45 µM 2.53904446091125 0.00976696887995017 no 90 0.00555778481340317 137 666570 SGTC_765 1319-0117 244 µM 2.53627213530973 0.00983298896029206 no 91 0.00560198151687014 90 3487746 YGL099W LSG1 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.52932514290731 0.010000139075456 no 92 0.00571410513317002 157 2724 A muscle relaxant with antifungal properties. SGTC_831 k061-1017 217 µM 2.52640809503922 0.0100710615858633 no 93 0.00576177673809091 208 1240153 SGTC_2456 5770359 74.46 µM 2.52548035257821 0.0100937097028033 no 94 0.00577701209322633 99 3118787 SGTC_2697 mebhydrolin 72.4 µM 2.52104053050079 0.0102027112781345 no 95 0.00585041869168296 187 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2969 9091408 28.7 µM 2.51508473047249 0.0103505430940308 no 96 0.00595018898461707 132 4286311 SGTC_670 4204-0025 119 µM 2.50549000789141 0.010592626753418 no 97 0.00611409266808659 132 719039 SGTC_2345 9052315 157.45 µM 2.50181471968038 0.0106866558628076 no 98 0.00617792843772562 127 6469265 SGTC_512 prima-1 270 µM 2.49134722493219 0.0109584517107139 no 99 0.00636298417775813 97 322968 A re-activator of the apoptotic function of mutant p53. SGTC_856 0433-0016 11.3 µM 2.47832456408375 0.0113049746414242 no 100 0.00660005041392783 103 3911780 SGTC_337 1315-0038 354 µM 2.47627371170301 0.0113604053365464 no 101 0.00663808772844693 113 1626437 SGTC_378 3970-0959 8.33 µM 2.47232345773382 0.0114678391210882 no 102 0.00671189986764118 112 6615653 SGTC_2236 dapsone 200 µM 2.46974807365486 0.0115383553012011 no 103 0.00676041171090157 100 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1279 0874-0590 65.2 µM 2.46803773206451 0.0115853937043971 no 104 0.00679279991854575 124 3523074 SGTC_349 k015-0014 24 µM 2.44772692659358 0.0121568431566646 no 105 0.00718802825109119 132 2196908 SGTC_1250 0485-0349 40.2 µM 2.43972354631437 0.0123886417928975 no 106 0.0073492526999956 147 6842794 YDL195W SEC31 SGTC_2053 5265679 138 µM 2.43581696179375 0.0125031703158242 no 107 0.00742910043041063 154 764595 SGTC_307 1501-1223 22.3 µM 2.42923511283398 0.0126982028294935 no 108 0.00756535839166913 99 2830329 SGTC_1668 st014914 51.6 µM 2.41751054291791 0.013052149866314 no 109 0.00781354064194395 84 2839556 SGTC_475 α-linolenic acid 10 µM 2.41197174732118 0.0132223027271579 no 110 0.00793325548390274 131 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3274 9138298 49.47 µM 2.40624394599659 0.0134002741640227 no 111 0.0080587490822619 130 17015756 SGTC_18 0111-0177 500 nM 2.40067344499497 0.0135753383398404 no 112 0.00818246662268951 212 721752 SGTC_208 k072-0098 12.366 µM 2.38105347465389 0.014207744797414 no 113 0.00863160287040246 203 5948901 SGTC_1523 st012844 44.7 µM 2.37726589701661 0.0143327088046991 no 114 0.00872075513936424 142 4274103 SGTC_1013 4112-3890 241 µM 2.37478338383346 0.0144151271932404 no 115 0.00877962579853755 152 705171 SGTC_1697 st025554 27.742 µM 2.35074424191325 0.0152345456082593 no 116 0.00936795348348565 116 1269519 SGTC_1094 duloxetine 25.4 µM 2.34437515488819 0.0154582385826813 no 117 0.00952949500952004 153 60834 A selective serotonin reuptake inhibitor. SGTC_687 k029-0044 34.9 µM 2.34035186815113 0.0156009914926566 no 118 0.00963278965360565 124 5829338 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.33786121453583 0.0156899297580958 no 119 0.00969722442189998 237 6708739 YPR165W RHO1 SGTC_141 0443-0274 32.331 µM 2.33692588112448 0.0157234415627468 no 120 0.00972151917453741 239 1627241 SGTC_1663 st014140 55.4 µM 2.3282847191743 0.0160359579054236 no 121 0.009948495082253 149 4207120 SGTC_91 0417-1751 58.384 µM 2.32397887152074 0.0161936606075909 no 122 0.0100633132362055 211 6795624 SGTC_2291 7917025 104.35 µM 2.32084504443983 0.0163092715259939 no 123 0.01014760421613 197 2964612 SGTC_3108 9121785 49.47 µM 2.31805247635416 0.0164128878713636 no 124 0.0102232346318164 152 17140271 SGTC_135 0933-0004 26.348 µM 2.31560905599889 0.0165040111669755 no 125 0.0102898119715503 166 21230617 YGL099W LSG1 SGTC_1399 3562-5772 25 µM 2.28197111648462 0.0178031621535008 no 126 0.0112455227860349 117 23847490 SGTC_3251 9135047 49.47 µM 2.28022929020908 0.0178727460565757 no 127 0.0112970465096714 85 17682963 SGTC_2010 4012422 159 µM 2.27704454067423 0.0180005729256007 no 128 0.0113917829826318 162 952393 SGTC_2941 9056145 11.23 µM 2.27679551108422 0.018010601048906 no 129 0.0113992198581266 100 2119517 SGTC_1107 amlodipine 47 µM 2.27398207074473 0.0181242262012038 no 130 0.0114835322712195 175 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_937 3122-0005 46.7 µM 2.27360301736286 0.0181395814667746 no 131 0.0114949329428599 173 759535 SGTC_1470 k295-0292 231 µM 2.26869359008677 0.0183394638762986 no 132 0.0116434828391118 144 5045612 SGTC_744 1594-0068 283 µM 2.26822374500905 0.0183586911515717 no 133 0.0116577864520767 192 668392 SGTC_3075 9116269 49.47 µM 2.26296728045246 0.0185749725165277 no 134 0.0118188531663375 141 17015205 YNL244C SUI1 SGTC_1201 1889-3372 45.9 µM 2.25259254105868 0.0190082201390281 no 135 0.0121424259273615 115 5392199 SGTC_1866 st057638 64 µM 2.24901390793353 0.0191596433409581 no 136 0.0122558056153154 135 688802 SGTC_2947 9072639 7.68 µM 2.24856653832435 0.0191786448696821 no 137 0.0122700436642835 219 16488146 SGTC_2983 9022671 12.99 µM 2.24588679831832 0.0192927995376278 no 138 0.0123556298497436 137 6405161 SGTC_1787 fluconazole 80 µM 2.23473470056189 0.019774091160745 no 139 0.0127173855290602 232 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2709 st078560 56 µM 2.2331408981438 0.0198437003996428 no 140 0.0127698271590631 140 17250903 SGTC_2331 7980721 200 µM 2.22891283716737 0.0200293690525889 no 141 0.0129098524080523 171 2981221 SGTC_2276 7947513 42.08 µM 2.21696918986064 0.0205618345501107 no 142 0.0133125985041124 172 2105100 SGTC_285 1486-1325 46 µM 2.21682639954964 0.0205682721997814 no 143 0.0133174783847081 164 22310230 SGTC_1803 st050068 52.4 µM 2.21654642669874 0.0205808996309767 no 144 0.0133270509841243 418 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2982 9019404 25.97 µM 2.21026330954179 0.0208660150896743 no 145 0.0135434467161744 172 22333232 SGTC_1503 4585-0012 61.3 µM 2.20180915479322 0.0212549184550195 no 146 0.0138393960702176 158 2922052 SGTC_2812 7970281 58.44 µM 2.20083831584406 0.021299968376731 no 147 0.0138737360105436 199 2233435 SGTC_350 k064-0020 19.8 µM 2.19997531811368 0.0213400818976816 no 148 0.013904323117139 193 2790705 SGTC_148 3253-0744 288.01 µM 2.18080257602467 0.0222478713002123 no 149 0.0145990109827023 172 6893655 SGTC_892 0929-0076 29 µM 2.17754663876037 0.0224052248025879 no 150 0.0147199029841664 238 5751038 SGTC_537 1334-0398 209 µM 2.17275487605199 0.0226385084967235 no 151 0.0148993855807201 188 5846986 SGTC_2840 9008771 71.43 µM 2.16880241366209 0.0228324692984222 no 152 0.0150488439629292 111 2992978 SGTC_1832 st054113 55 µM 2.16548419110076 0.0229963852194685 no 153 0.0151753123865785 120 1251267 SGTC_3153 9100258 49.47 µM 2.16414525741535 0.0230628069039745 no 154 0.015226601533355 190 25236848 SGTC_72 0744-0168 198.391 µM 2.1544908697503 0.0235465389486468 no 155 0.0156008486101904 182 677577 SGTC_166 k072-0058 166.424 µM 2.15432469856199 0.0235549390860056 no 156 0.015607358636728 189 5846229 SGTC_2118 5526350 200 µM 2.15304785773546 0.0236195689377588 no 157 0.0156574587677582 187 743594 SGTC_2210 7115885 190.385 µM 2.1527051693233 0.0236369401605804 no 158 0.0156709284911929 186 2927039 SGTC_2784 7567673 72.73 µM 2.14954156644429 0.0237978144193164 no 159 0.0157957473948664 235 3471247 SGTC_1769 st044406 64.4 µM 2.14342660177295 0.0241113798944366 no 160 0.016039429467893 178 670903 SGTC_2547 epiafzelechin trimethyl ether 100 µM 2.14162752579031 0.0242042917379713 no 161 0.0161117334576198 74 6708630 An antioxidant. SGTC_198 3454-2873 16.191 µM 2.13409190669671 0.0245967367665116 no 162 0.0164176291292895 172 710957 SGTC_1772 st048439 82.2 µM 2.13281281583159 0.0246638773637783 no 163 0.016470042255646 221 2927068 YDL195W SEC31 SGTC_2156 5649887 115 µM 2.11281154449415 0.0257339203297336 no 164 0.0173084505883463 211 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_493 zm226600 134 µM 2.11012987746414 0.0258802974832426 no 165 0.0174235852170038 196 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1179 1021-1431 9.29 µM 2.10916847339515 0.0259329445023117 no 166 0.0174650210718789 256 2840958 SGTC_791 1348-1292 225 µM 2.10638960024949 0.0260856211400044 no 167 0.0175852619588034 263 5437054 SGTC_299 1273-0059 1.44 µM 2.09340035810163 0.0268092789862358 no 168 0.0181567152448479 174 2848077 SGTC_1618 st003135 44.5 µM 2.08896015151882 0.0270604651852501 no 169 0.0183556551889228 160 1270615 SGTC_1293 1000-1278 195 µM 2.08851585392695 0.0270857072159513 no 170 0.0183756634023842 204 678847 SGTC_2436 5633522 8.09 µM 2.08808061779021 0.0271104534837151 no 171 0.0183952815582913 210 5724242 SGTC_118 0083-0097 135.343 µM 2.08474322178498 0.0273008358177349 no 172 0.0185463075294079 455 5207356 SGTC_3147 9097027 49.47 µM 2.08457787900556 0.0273102967444972 no 173 0.0185538170936127 204 25236841 SGTC_95 0471-0001 561.058 µM 2.0812478150494 0.0275014261789072 no 174 0.0187056145083445 211 4015405 SGTC_1458 k015-0034 6.33 µM 2.066722843606 0.0283481759047893 no 175 0.0193801386927431 183 3598957 SGTC_2192 5915882 198.485 µM 2.0553128268055 0.0290284536811148 no 176 0.019924399600159 154 2876149 SGTC_1188 1403-0014 4.57 µM 2.05521397102896 0.0290344063299305 no 177 0.0199291711426881 283 9614867 SGTC_3021 9087658 49.47 µM 2.04895172618536 0.0294135629813378 no 178 0.020233417788037 134 25237042 SGTC_2466 5983409 37.09 µM 2.0489114720465 0.0294160134608349 no 179 0.0202353861740916 187 2879657 SGTC_902 1120-0002 2.07 µM 2.04831202963778 0.0294525247090601 no 180 0.0202647175081431 244 3280475 SGTC_1427 4048-4900 550 nM 2.04586028900145 0.029602248854084 no 181 0.020385059173583 194 24132586 SGTC_1759 st043059 70 µM 2.04493450974284 0.0296589488693092 no 182 0.0204306575515235 208 669426 SGTC_2265 7929201 200 µM 2.03998828746007 0.0299634128929673 no 183 0.0206757461585544 218 1265108 SGTC_97 0535-0701 19.132 µM 2.03141286272997 0.0304974128240874 no 184 0.0211065653474379 181 2832013 YGL099W LSG1 SGTC_2075 5212009 200 µM 2.01879491776419 0.0312974582069914 no 185 0.0217542697598648 159 780898 SGTC_3193 9111931 49.47 µM 2.01523893039141 0.0315260363528363 no 186 0.0219398101311072 218 17087244 SGTC_2174 5790901 200 µM 2.01269775663142 0.0316902264747906 no 187 0.0220732177717798 238 786020 SGTC_2246 7293507 91.5585 µM 1.99585303809589 0.0327965477009694 no 188 0.0229749608544993 230 887656 SGTC_766 1391-0721 126 µM 1.99196386759932 0.0330564532304814 no 189 0.0231875112375384 211 1020919 YIL115C NUP159 SGTC_1700 st030840 7.9285 µM 1.99102995078708 0.033119117089872 no 190 0.023238797297164 222 5499307 SGTC_1444 4112-3581 28 µM 1.99044012870629 0.0331587433129324 no 191 0.0232712365580177 212 2877249 SGTC_2384 9036245 200 µM 1.98338826709026 0.0336355430461703 no 192 0.0236620383399321 205 6462766 SGTC_2765 myclobutanil 7.74 µM 1.98278537430658 0.033676567127905 no 193 0.0236957041982686 243 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_452 diindolylmethane 8 µM 1.97704359374445 0.0340693359860823 no 194 0.0240183513896912 180 3071 Inhibits expression of several cancer promoting factors. SGTC_22 0964-0034 14.468 µM 1.96855212477823 0.0346570958334905 no 195 0.0245022724262947 286 138402 SGTC_631 k072-0230 41.5 µM 1.96614799957206 0.0348250083236958 no 196 0.0246407585874583 236 5773147 SGTC_167 3672-0051 66.205 µM 1.95675719890353 0.0354873060906427 no 197 0.0251880107107145 238 3237971 SGTC_3326 9140064 16.379 µM 1.95589819779949 0.0355484003127882 no 198 0.0252385738444924 205 1868434 SGTC_440 fluspirilene 35.1 µM 1.9517397805268 0.035845377164845 no 199 0.0254845535398049 241 3396 An atypical antipsychotic. SGTC_1137 ixabepilone 100 µM 1.95032618517222 0.0359467920309907 no 200 0.0255686267933772 286 154225 A novel microtubule stabilizer. SGTC_1428 4049-0204 61.7 µM 1.94224532553292 0.0365310543012576 no 201 0.0260537041947497 223 X1428 SGTC_639 0833-0042 114 µM 1.93464681718028 0.0370875075262572 no 202 0.0265168253769995 266 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1708 st033234 31.827 µM 1.92911391481365 0.0374970357175063 no 203 0.0268583609616492 242 674664 SGTC_2691 st077356 60.2 µM 1.92792561358771 0.0375854700561387 no 204 0.0269321896517856 253 2839272 SGTC_3225 9130819 49.47 µM 1.92337848864084 0.0379254446258674 no 205 0.0272162669339171 243 4547121 SGTC_237 nikkomycin 200 µM 1.91640285849232 0.038451864472845 no 206 0.0276569186305313 251 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_576 1073-0113 22.7 µM 1.91186674948736 0.0387973691992442 no 207 0.0279466437480827 378 5439563 SGTC_2408 sulbentine 18.36 µM 1.90872397583924 0.0390382265625258 no 208 0.0281488542790541 267 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_975 1335-0046 28.5 µM 1.9079780087177 0.0390955747517602 no 209 0.0281970293313292 282 16486740 SGTC_1049 3226-0134 66 µM 1.90331062290033 0.0394559510920101 no 210 0.0285000127675094 285 5702385 SGTC_203 k066-0004 30.888 µM 1.89977976223925 0.0397303660962395 no 211 0.0287310139199625 303 6795412 SGTC_2385 9074692 200 µM 1.8980002730779 0.0398692532050783 no 212 0.0288480230276342 285 17046906 SGTC_2989 9073649 71.4286 µM 1.89545749644693 0.0400683986371622 no 213 0.0290159088064535 341 21367202 SGTC_2086 5274770 176.623 µM 1.89493385999739 0.0401095090403521 no 214 0.0290505823101126 256 689278 SGTC_1276 0871-0068 94.2 µM 1.89301278345576 0.0402606252536806 no 215 0.0291780847370951 224 3414906 SGTC_318 1488-0629 67.2 µM 1.8899342172328 0.0405037562407141 no 216 0.0293833792792663 221 3662576 SGTC_718 1130-0073 349 µM 1.88793018646969 0.040662664911845 no 217 0.02951766171053 266 6740020 SGTC_886 0866-0150 153 µM 1.8771051940616 0.0415297966075401 no 218 0.030251838833641 289 271463 SGTC_2608 thymoquinone 42.66 µM 1.87258418733652 0.041896357789282 no 219 0.0305629132848271 228 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2089 5281248 129.67 µM 1.87060522315804 0.0420576334967395 no 220 0.0306999100549049 267 2737878 SGTC_2193 5925765 200 µM 1.86812205336183 0.0422607098907132 no 221 0.0308725301276709 193 877370 SGTC_2270 7924575 90.91 µM 1.86394214982554 0.0426043381870627 no 222 0.0311649143652642 256 1262135 SGTC_464 bw-b 70c 158 µM 1.86235745525749 0.0427352045013804 no 223 0.0312763609146461 299 5353454 SGTC_1238 0333-0287 48.8 µM 1.86204015785867 0.0427614463729258 no 224 0.031298714992982 255 7226 SGTC_1054 3429-0080 167 µM 1.86120735293638 0.042830384915774 no 225 0.0313574502080258 284 1162877 SGTC_2791 5663188 71.43 µM 1.85932305667261 0.0429866961449229 no 226 0.0314906803748364 258 54690634 SGTC_1800 st050079 29.0735 µM 1.85827208542044 0.0430740791832919 no 227 0.0315651929117826 471 3645560 SGTC_2529 gangaleoidin 93.61 µM 1.85770045050781 0.0431216680038082 no 228 0.0316057822544868 223 4565183 SGTC_2205 7238770 200 µM 1.85474537565708 0.0433683567504448 no 229 0.0318162978766269 203 279867 SGTC_1474 0330-0125 5.35 µM 1.85128323586254 0.043658823241986 no 230 0.0320644082716144 254 X1474 SGTC_3258 9138477 49.47 µM 1.85026772082815 0.0437443200236193 no 231 0.0321374863050368 254 4970355 SGTC_968 1309-0633 340 µM 1.84692401689685 0.0440267833520808 no 232 0.0323790766935678 249 3761976 SGTC_1053 3366-3204 134 µM 1.84666884869017 0.0440483992495442 no 233 0.0323975745693509 293 3632071 YPR165W RHO1 SGTC_2005 4024620 188 µM 1.8465257360343 0.0440605264035873 no 234 0.0324079530325438 247 236743 SGTC_1086 cerivastatin 2.18 µM 1.84060610548983 0.0445645103092424 no 235 0.0328396511902182 211 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_763 3453-1109 128 µM 1.8386599172364 0.0447312151025916 no 236 0.0329826112131923 279 1560353 SGTC_2434 5670830 169.91 µM 1.83135728101997 0.0453612198070735 no 237 0.0335236165453504 302 1549830 SGTC_828 2074-0507 139 µM 1.8299332146196 0.0454849029198923 no 238 0.0336299630180458 301 X828 SGTC_1336 1486-0901 104 µM 1.82663025798878 0.0457728155721223 no 239 0.033877690374697 279 5006114 SGTC_2151 5563267 85.4165 µM 1.82644374668745 0.0457891170102906 no 240 0.0338917236959886 287 5310824 SGTC_599 1935-0052 86.5 µM 1.80786850652975 0.0474361411174838 no 241 0.0353134841883961 301 9557311 SGTC_366 0181-0206 4.31 µM 1.79938016660474 0.0482044211712975 no 242 0.0359792823635404 338 274874 SGTC_1098 clofazimine 15.1 µM 1.79901104185653 0.048238055229142 no 243 0.0360084670380608 327 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2269 7935389 174.42 µM 1.79314331520166 0.0487752385789101 no 244 0.0364750055632106 286 97605 SGTC_1151 3909-8316 15.3 µM 1.79106984977331 0.0489662011723463 no 245 0.0366410433623242 291 800431 SGTC_2298 7976326 193.81 µM 1.78138014081549 0.0498665378339236 no 246 0.0374251851368029 221 2235818 SGTC_117 lucigenin 22.078 µM 1.78073623449765 0.0499268323611965 no 247 0.0374777753802497 386 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_88 0180-0332 8.668 µM 1.77762947909082 0.0502185622404033 no 248 0.037732364436665 294 3101745 SGTC_2646 retinol 96.75 µM 1.77615286489723 0.0503576945177909 no 249 0.0378538624101075 268 445354 A vitamin A analog and teratogen. SGTC_2634 4'-methoxyflavone 100 µM 1.77441666190929 0.0505216789933483 no 250 0.0379971279109947 289 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2113 5491891 107.031 µM 1.77424200857678 0.0505381985336211 no 251 0.0380115641584293 310 789979 SGTC_139 0099-0334 718.624 µM 1.77419818910778 0.0505423438619262 no 252 0.0380151868279973 360 97690 SGTC_3008 9078912 71.4286 µM 1.77231418866491 0.0507208269024281 no 253 0.0381712086244653 260 16648731 SGTC_938 3126-1755 342 µM 1.77168009970577 0.0507810108515371 no 254 0.0382238374414862 286 1777771 SGTC_1413 3910-0535 34.4 µM 1.76938664220149 0.0509991671067242 no 255 0.0384146866268913 291 2876951 SGTC_2771 fluoxetine 41.05 µM 1.76419566427358 0.0514956938201649 no 256 0.038849521233037 270 3386 A selective serotonin reuptake inhibitor. SGTC_211 3455-0679 143.504 µM 1.7619548811438 0.0517112133639945 no 257 0.0390384604565343 321 748649 SGTC_2412 st077135 33.4 µM 1.75914560879893 0.0519824227141502 no 258 0.0392763899422931 311 13258915 SGTC_790 1575-0012 79.1 µM 1.75647363340901 0.052241424777115 no 259 0.0395037848257157 316 378741 YLR208W SEC13 SGTC_3320 9137005 35.139 µM 1.7559546749965 0.052291847522986 no 260 0.0395480740393295 261 4908713 SGTC_1073 triclabendazole 3.09 µM 1.74844051313039 0.0530262734956464 no 261 0.040193888920238 354 50248 An antihelmetic and likely tubulin inhibitor. SGTC_9 0092-0002 10.449 µM 1.74239350027914 0.053623222148148 no 262 0.0407198062363364 313 759368 SGTC_100 0086-0128 49.5915 µM 1.73973217348737 0.0538876241963935 no 263 0.0409530285737935 381 93297 SGTC_1845 st056753 3.01 µM 1.72470902457297 0.0553995811566425 no 264 0.0422899619292057 342 5375839 SGTC_2686 alizarin 95.37 µM 1.72342811386729 0.0555300288084361 no 265 0.0424055672495239 306 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3344 9148862 3.898 µM 1.71811756416679 0.0560734423237878 no 266 0.0428875868702256 291 4905352 SGTC_747 3448-8087 38.7 µM 1.71657930802321 0.0562316285853392 no 267 0.0430280329319842 342 5168703 SGTC_2680 butyl paraben 22.24 µM 1.71647057784444 0.0562428231314353 no 268 0.0430379742729454 254 7184 An antifungal and steroid mimetic. SGTC_1140 3229-1848 2.98 µM 1.71453855001134 0.0564420322882825 no 269 0.0432149317100973 262 2849525 SGTC_577 r071-0003 38.6 µM 1.71081526840236 0.0568275036359609 no 270 0.0435576100412744 455 4568517 YMR134W ERG29 SGTC_861 0443-0273 110 µM 1.7083337175864 0.057085567964868 no 271 0.0437872191783569 289 6149169 SGTC_1767 st044992 70.3 µM 1.70148314223223 0.0578027710780004 no 272 0.0444261503519889 354 9600693 SGTC_3157 9099274 49.47 µM 1.70129476165598 0.0578225927144261 no 273 0.0444438255699816 275 17217662 SGTC_2907 7721985 69.9 µM 1.70054620619467 0.0579014094524966 no 274 0.0445141164149574 337 3267881 SGTC_3265 9137266 49.47 µM 1.70018278380752 0.0579397052833614 no 275 0.0445482747807521 258 17224265 SGTC_630 4356-0227 183 µM 1.6974626709502 0.0582269711320203 no 276 0.0448046113664519 292 779312 SGTC_2738 aclarubicin 5.55 µM 1.69285288789146 0.0587163548955649 no 277 0.045241736391707 218 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_859 0439-0102 54.6 µM 1.69007904845978 0.0590123834169581 no 278 0.0455064163042104 345 610143 SGTC_2889 9059656 51.95 µM 1.68949259097418 0.0590751207713793 no 279 0.0455625352579767 325 3949838 SGTC_879 0831-1030 162 µM 1.68670568661535 0.0593739702438346 no 280 0.0458299790508586 405 1549252 SGTC_806 3966-4455 5.86 µM 1.68519705562022 0.0595362397551498 no 281 0.045975279479623 298 714982 SGTC_212 3807-4682 38.772 µM 1.68211644663302 0.0598686718104799 no 282 0.0462731308914156 466 3125501 YBL034C STU1 SGTC_2980 9014342 25.29 µM 1.68116973977734 0.0599711235733539 no 283 0.0463649746891516 331 2996599 SGTC_558 k064-0027 21.3 µM 1.68052234119457 0.0600412634806674 no 284 0.0464278656184572 336 5088526 SGTC_2630 antimycin a 100 µM 1.6734258446036 0.0608143237406223 no 285 0.0471217467868313 378 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1196 1588-0294 184 µM 1.67277664785801 0.0608854311167591 no 286 0.0471856368236556 309 6144269 SGTC_722 3534-0461 190 µM 1.66943492421319 0.0612524835520254 no 287 0.0475156085724239 351 658262 SGTC_114 0364-0001 490.298 µM 1.66251982376031 0.0620175219471259 no 288 0.0482042959743278 367 4003655 SGTC_2523 spermine 47.74 µM 1.65578566199667 0.0627696885301885 no 289 0.0488826162015683 325 1103 A DNA binding polyamine. SGTC_1062 mesoridazine 14.2 µM 1.65469484399473 0.0628921927641811 no 290 0.0489932067424274 358 4078 A neuroleptic. SGTC_442 cape 100 µM 1.65407740033914 0.0629616172395497 no 291 0.0490558936485538 296 5281787 SGTC_3117 9124945 49.47 µM 1.65341520682271 0.0630361396548758 no 292 0.0491231950401742 270 17592065 SGTC_1854 st056233 32.9 µM 1.65167438481741 0.0632323772634159 no 293 0.0493004735914824 325 5393174 SGTC_2955 9076254 12.21 µM 1.64519738329807 0.0639666897286114 no 294 0.0499645564910944 323 16459619 SGTC_1786 berberine 21.6 µM 1.63834663255683 0.0647505732248649 no 295 0.0506747025330148 374 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1393 3470-5649 58.2 µM 1.63749003260651 0.0648491103917912 no 296 0.0507640599539937 269 4108395 SGTC_2908 7930301 100 µM 1.63298289409816 0.0653694986077977 no 297 0.0512362971967295 391 2223178 SGTC_2803 7707263 71.43 µM 1.62992677770747 0.0657241925690792 no 298 0.0515584867052383 321 2199229 SGTC_1307 1187-1599 12.2 µM 1.62556964118634 0.066232460915432 no 299 0.0520206189130943 339 1538471 SGTC_1342 1486-1464 234 µM 1.62331606760896 0.0664965363528207 no 300 0.0522609282535215 362 3253938 SGTC_1614 st002383 48.6 µM 1.62195738997799 0.0666561406189826 no 301 0.0524062359866723 365 1947235 SGTC_522 1273-0010 11.6 µM 1.61900496610049 0.067003984693905 no 302 0.0527230973056232 342 5705015 SGTC_848 0368-0089 85.6 µM 1.6152712602759 0.0674458850933736 no 303 0.0531259822826801 372 762535 SGTC_2496 diffractaic acid 79.83 µM 1.60793699578313 0.0683204812690705 no 304 0.0539244891164757 389 94870 An apoptosis inducer which activates caspases. SGTC_277 nystatin 15.5 µM 1.60770943798622 0.0683477563965925 no 305 0.0539494152796156 380 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_296 1222-0039 74.9 µM 1.60453047682491 0.0687296665072538 no 306 0.0542985860851835 358 5984176 SGTC_2517 totarol 10 µM 1.60313672191722 0.0688976257146593 no 307 0.0544522360782168 343 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1172 0370-0043 85 µM 1.60305189450595 0.0689078583381713 no 308 0.0544615986922025 332 376585 SGTC_1205 4161-2785 76 µM 1.6022337627438 0.069006608685286 no 309 0.0545519633190171 345 3498106 SGTC_1500 4488-1866 171 µM 1.60080792990044 0.0691789705650339 no 310 0.0547097333483525 398 2900003 SGTC_438 sphingosine 6.67 µM 1.59800218362192 0.0695191117413144 no 311 0.0550212455616846 303 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1486 3970-0793 4.53 µM 1.59741882172364 0.069589994267431 no 312 0.0550861898506253 344 2844330 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.59635703156936 0.0697191519513354 no 313 0.0552045518360576 346 2346 DNA damaging agent; causes G2/M arrest. SGTC_1041 0206-0046 107 µM 1.59399851028346 0.0700067059745072 no 314 0.0554681842844749 367 50494 SGTC_1662 st014054 52 µM 1.59396179504592 0.0700111895467771 no 315 0.0554722961094548 308 2838777 SGTC_2195 6536160 144.242 µM 1.58981075770634 0.0705195296707971 no 316 0.055938734131029 334 3834386 SGTC_2761 levamisole 97.89 µM 1.58600324525755 0.0709882917726794 no 317 0.0563692866955261 350 26879 An alkaline phosphatase inhibitor. SGTC_1069 diphenylcyclopropenone 8.49 µM 1.58056074355623 0.0716624963860507 no 318 0.0569892538470752 449 65057 A dermal irritant. YDR527W RBA50 SGTC_3031 9088762 49.47 µM 1.57941982047864 0.0718044521348432 no 319 0.057119897032717 386 205253 SGTC_3090 9117696 49.47 µM 1.57877854854665 0.071884334991523 no 320 0.0571934303039004 348 7923821 SGTC_869 0564-0080 44.1 µM 1.57386199749483 0.0724990527267756 no 321 0.0577596786288348 418 6843321 SGTC_3001 9076041 71.4286 µM 1.57258717748274 0.0726590993906544 no 322 0.0579072193253023 362 16004211 SGTC_1522 st012842 45.6 µM 1.57094088044921 0.072866183118148 no 323 0.0580981908581434 362 3491067 YOR116C RPO31 SGTC_183 3914-0051 30.55 µM 1.5682680479744 0.0732033541156287 no 324 0.0584092947321765 377 1596232 SGTC_973 1325-0077 65.9 µM 1.56632276683613 0.0734494959525756 no 325 0.0586365368481111 412 2835149 SGTC_185 k048-0037 25.491 µM 1.56414303361031 0.0737260550883852 no 326 0.0588919908885734 378 6827589 SGTC_990 3985-0011 41.3 µM 1.55254004118452 0.0752116270147686 no 327 0.0602665298011311 347 5399565 YGL099W LSG1 SGTC_3050 9093513 49.47 µM 1.55208378603491 0.0752705059427414 no 328 0.0603210885199996 371 25236664 SGTC_26 0302-0163 425.158 µM 1.5412979217684 0.0766726585882864 no 329 0.061622147235045 366 3100915 SGTC_253 dyclonine 31.25 µM 1.53752494878044 0.0771678031753218 no 330 0.0620824051681051 448 3180 An oral anasthetic. SGTC_3194 9111903 49.47 µM 1.53205393762159 0.0778900999103586 no 331 0.0627545625911947 404 17087251 SGTC_3284 9108171 64.8615 µM 1.53184441132629 0.0779178637629161 no 332 0.0627804168820758 350 8687505 SGTC_1264 0783-0040 158 µM 1.52780177237297 0.0784550160030496 no 333 0.0632808810468397 381 2855798 SGTC_581 0958-0271 211 µM 1.52179949012864 0.0792577214008776 no 334 0.064029664646856 499 4591145 SGTC_2519 cryptotanshinone 88.04 µM 1.51878970302157 0.0796625636683104 no 335 0.0644077192954809 357 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1072 oxiconazole 14.9 nM 1.51622551452411 0.0800087016085398 no 336 0.0647311692767776 451 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3245 9134821 49.47 µM 1.51424368807649 0.0802770050763743 no 337 0.0649820224691771 435 17014901 SGTC_3170 9103054 49.47 µM 1.51212964726206 0.0805639569013977 no 338 0.0652504420172546 376 16432970 SGTC_1666 st014829 29 µM 1.51159756694617 0.0806363013457141 no 339 0.0653181355160966 443 3858230 SGTC_590 k048-0076 22.4 µM 1.50816886028074 0.0811036635999655 no 340 0.0657556574494256 412 6832814 SGTC_1927 st060202 13.8 µM 1.50763683879738 0.0811763655448044 no 341 0.0658237494575172 396 688887 SGTC_2505 galangin 7.89 µM 1.50752970952949 0.081191010948795 no 342 0.0658374672542244 337 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3009 9080819 71.4286 µM 1.50558737010957 0.0814568897238525 no 343 0.0660865663423411 401 17027216 SGTC_1505 k297-0037 20.6 µM 1.50558205743322 0.0814576178534612 no 344 0.0660872486767072 435 4089396 SGTC_3123 9126162 49.47 µM 1.49435062813581 0.08300794268869 no 345 0.0675419993932141 406 25239884 SGTC_444 curcumin 90.4 µM 1.49206212610409 0.0833265390570881 no 346 0.0678414297445408 446 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2453 5731132 22.18 µM 1.48651866349421 0.08410208744184 no 347 0.0685709919900831 449 1362040 SGTC_1178 0988-0033 191 µM 1.48478242235548 0.0843461042047378 no 348 0.0688007348403076 466 5392207 SGTC_1626 st003712 1.76 µM 1.48440446361998 0.0843992940541209 no 349 0.0688508256550496 402 24207035 SGTC_1235 benzylparaben 21.5 µM 1.48188808890176 0.0847540633346485 no 350 0.0691850374423624 417 7180 SGTC_1344 1488-0097 29.1 µM 1.48036337419632 0.0849695675267841 no 351 0.0693881494237174 418 747966 SGTC_1616 st002734 56.1 µM 1.48015426121691 0.0849991556960059 no 352 0.0694160417905871 457 4026101 SGTC_1251 0490-5699 265 µM 1.47992537764566 0.085031550131272 no 353 0.0694465811397201 488 3883818 SGTC_2739 tacrine 100.86 µM 1.47928677460899 0.0851219820605668 no 354 0.0695318430189468 387 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2390 9097792 176.6 µM 1.47925654080976 0.0851262652244512 no 355 0.0695358816251227 406 4497149 SGTC_2196 6573537 42.6665 µM 1.47823597649808 0.0852709413559101 no 356 0.0696723137544053 376 2903087 SGTC_2173 5763948 167 µM 1.47519862293442 0.0857026093171028 no 357 0.0700795757922892 449 2867177 SGTC_1077 5-fluorocytosine 377 nM 1.47239264589841 0.0861028459608975 no 358 0.0704574389608066 411 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1275 0867-0008 21.1 µM 1.4672919777853 0.086833969458287 no 359 0.071148322539078 451 3422836 SGTC_2843 9000894 45.46 µM 1.46723879297848 0.0868416172628831 no 360 0.0711555537056941 293 2242070 SGTC_2835 9006588 71.43 µM 1.46525738617746 0.0871268959549843 no 361 0.0714253540720801 457 2345538 SGTC_1406 3909-7906 11.9 µM 1.46126513284982 0.087703816693136 no 362 0.0719713472942487 438 X1406 SGTC_918 glabranin 770.725 nM 1.45841401135578 0.0881175735830203 no 363 0.0723632304660747 470 124049 Also referred to as licorice root. SGTC_588 3970-1144 52.9 µM 1.45741076225869 0.0882635114291982 no 364 0.0725015140260423 468 1888707 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.4557204804832 0.0885097959377734 no 365 0.0727349529372654 492 5106787 A p450 inhibitor. SGTC_2862 9027634 71.43 µM 1.45542250236385 0.0885532662246048 no 366 0.0727761652616196 432 5012562 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.45414955829445 0.0887391477015246 no 367 0.072952423116374 486 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2460 5552655 174.22 µM 1.45319238325324 0.0888791103281485 no 368 0.073085173180684 450 5401989 SGTC_2397 5161689 200 µM 1.45200294142127 0.0890532650311738 no 369 0.0732503936856109 476 2259942 SGTC_884 0851-0618 334 µM 1.45092187669976 0.089211771680407 no 370 0.0734008077087258 476 9642473 SGTC_146 3448-8650 53.125 µM 1.4491132582622 0.0894774221276689 no 371 0.0736529780162374 623 2891488 YIL048W NEO1 SGTC_3264 9137442 49.47 µM 1.446985776613 0.0897906598386608 no 372 0.0739504536166083 405 17015726 SGTC_1818 st052136 56.3 µM 1.44203850884619 0.0905222164703663 no 373 0.0746457551737034 467 674169 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.43786049204186 0.091143461966269 no 374 0.0752368207265856 729 16725076 SGTC_3059 1327-0034 3 µM 1.43777207999094 0.0911566423734323 no 375 0.0752493668523518 474 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2085 5307070 144.047 µM 1.43608222613689 0.0914088363751227 no 376 0.0754894725178026 407 2840351 SGTC_92 0063-0024 660.874 µM 1.43583425915796 0.0914458864699326 no 377 0.0755247543802438 498 3594437 SGTC_1001 4048-4355 44.4 µM 1.4346125573924 0.0916285901015705 no 378 0.0756987671128526 436 21824233 SGTC_1670 st016595 4.04 µM 1.43411602626462 0.0917029228265233 no 379 0.075769577605628 471 597879 SGTC_1371 2421-0008 32.7 µM 1.43086085838797 0.0921913414734859 no 380 0.0762350484635278 476 2827552 SGTC_2323 6148992 148.28 µM 1.42613896230112 0.0929032527711248 no 381 0.0769141170597616 410 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1617 st002906 78 µM 1.4255785100832 0.0929880201900947 no 382 0.0769950215157211 488 5150859 SGTC_3183 9108214 49.47 µM 1.42112064870338 0.093664300814339 no 383 0.0776408440313742 311 4974831 SGTC_126 0417-1624 672.48 µM 1.41997238588324 0.0938390849567761 no 384 0.0778078602302383 583 41912 YDL195W SEC31 SGTC_50 0929-0078 56.389 µM 1.41741736875791 0.0942288634335083 no 385 0.0781804687673125 462 1377751 SGTC_272 doxorubicin 8.13 µM 1.41666438164713 0.0943439622653418 no 386 0.0782905377385009 518 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_954 1189-0853 2.85 µM 1.41559665433841 0.0945073488227899 no 387 0.0784468157194352 481 2828194 SGTC_3048 9093155 49.47 µM 1.41473194253593 0.0946398222036304 no 388 0.0785735525552142 393 25236002 SGTC_922 1866-0035 480 µM 1.41128526520757 0.0951692114640596 no 389 0.0790802587081226 556 3156169 SGTC_3100 9120536 49.47 µM 1.41066843671295 0.0952641822847992 no 390 0.0791712009558071 341 16421196 SGTC_2796 7949634 45.45 µM 1.40262136661306 0.096509559640122 no 391 0.0803648884255336 464 2971588 SGTC_2837 9008476 45.46 µM 1.4011345147929 0.0967409705184299 no 392 0.0805869260765572 510 2992805 SGTC_1376 2910-0861 41.3 µM 1.40002035627819 0.0969146430000412 no 393 0.0807536113832577 514 1112859 SGTC_159 3970-0959 50 µM 1.39236870581361 0.0981135524096999 no 394 0.0819053879258879 700 6615653 SGTC_1407 3909-7909 12.3 µM 1.39218091298042 0.0981431129953985 no 395 0.0819338105741068 495 4411780 SGTC_1067 clotrimazole 1.36 µM 1.38707522302803 0.0989493047381205 no 396 0.0827094131683182 519 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_823 0417-1665 178 µM 1.38490670839643 0.0992931765526615 no 397 0.0830404977509288 496 3429856 SGTC_1212 0520-0165 585 µM 1.38382644798077 0.0994648043354037 no 398 0.0832058013068647 497 5403258 SGTC_2055 5235184 200 µM 1.38346000064062 0.09952307335909 no 399 0.0832619319571229 500 2836034 SGTC_2819 7996655 46.38 µM 1.37835028337045 0.100338173483237 no 400 0.0840475826642739 425 6456960 SGTC_2268 7933382 153.85 µM 1.37727214285934 0.100510778728143 no 401 0.0842140622557255 569 935025 YOR257W CDC31 SGTC_793 0488-0545 106 µM 1.37297273300034 0.101201248560074 no 402 0.0848804117796272 502 292548 SGTC_1534 6-azauridine 81.6 µM 1.37000703976185 0.101679538543013 no 403 0.0853423520633785 554 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2938 9059746 27.26 µM 1.36728702945969 0.102119651241072 no 404 0.0857676778066665 457 6471769 SGTC_1736 st036774 51 µM 1.36711226027503 0.10214797717414 no 405 0.0857950604728452 520 1272247 SGTC_2884 9058502 51.95 µM 1.3668504662602 0.102190418458081 no 406 0.0858360903469107 509 6471554 SGTC_2469 5655019 90.81 µM 1.36553488594063 0.102403890718845 no 407 0.0860424980739447 509 2788239 SGTC_2580 diallyl disulphide 81.36 µM 1.36446988314665 0.102576940453559 no 408 0.0862098633079432 475 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3317 9138495 8.753 µM 1.36394903085882 0.102661649849709 no 409 0.0862918038789066 524 17020139 SGTC_864 0469-0573 172 µM 1.36233593778149 0.102924319609356 no 410 0.0865459454871669 483 689425 SGTC_2238 6671620 73.2395 µM 1.35998377183068 0.103308211650892 no 411 0.0869175296741084 482 729941 SGTC_2863 9028737 58.44 µM 1.35790180444501 0.103648871525638 no 412 0.087247422375125 433 6460917 SGTC_2743 auranofin 4.32 µM 1.35574670155174 0.104002355879223 no 413 0.0875898873366914 479 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1831 st055328 12 µM 1.35399598016959 0.104290155630401 no 414 0.0878688300964802 503 1103068 SGTC_1799 st045822 46.1415 µM 1.3534496112408 0.104380090869472 no 415 0.0879560186638935 484 3674992 SGTC_74 000s-0487 160.283 µM 1.35326382419225 0.104410685209175 no 416 0.0879856809195078 501 677548 SGTC_2958 9077254 16.72 µM 1.35311592013968 0.104435045840702 no 417 0.0880093002111967 469 16457351 SGTC_340 k038-0059 454 µM 1.34945688128186 0.105039021946018 no 418 0.088595130562022 526 23733424 SGTC_2827 7993847 71.43 µM 1.34502225031477 0.105774404362584 no 419 0.0893090246340964 460 2985692 SGTC_2664 lyso-paf C-16 73.48 µM 1.34276489913518 0.106150160779892 no 420 0.0896740562717378 527 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_453 enantio-paf c16 10 µM 1.3425813984614 0.106180748444827 no 421 0.0897037784709541 701 13871343 A lipid and platelet activating factor SGTC_7 0192-1582 4.227 µM 1.3406743673726 0.106499007775305 no 422 0.0900131001623511 629 252616 SGTC_137 0438-0332 85.389 µM 1.33974351287069 0.106654605485303 no 423 0.0901643729091243 667 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_785 1270-0111 65.3 µM 1.33957424195479 0.106682917719592 no 424 0.0901919013311156 509 6741994 SGTC_2782 7736369 71.43 µM 1.33709184891784 0.107098745711763 no 425 0.0905963287587344 545 2950836 YOL077C BRX1 SGTC_459 nigericin 15.3 µM 1.3356231588541 0.107345317072985 no 426 0.0908362383184302 553 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2106 5357045 167.29 µM 1.33327874551683 0.107739756971075 no 427 0.0912201730035473 537 668842 SGTC_2757 clomiphene 4.22 µM 1.33241129046688 0.107885967767051 no 428 0.0913625370187772 602 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2401 5128683 200 µM 1.32964907188538 0.108352495551107 no 429 0.0918169609402892 490 708373 SGTC_1775 st081588 35.1725 µM 1.32761734814885 0.108696571044945 no 430 0.0921522752527378 578 1426443 YGL099W LSG1 SGTC_789 1309-1135 70.6 µM 1.32699387352888 0.108802314811274 no 431 0.0922553546404035 549 3092424 SGTC_2071 5230951 39.92 µM 1.32579404813889 0.109006018048682 no 432 0.0924539625066913 558 1799272 SGTC_1388 3346-4487 254 µM 1.32517548857871 0.109111142510166 no 433 0.0925564765736984 579 3345614 SGTC_1812 st052057 4.327 µM 1.32288868706118 0.109500417931729 no 434 0.0929361990077408 552 3645418 SGTC_1722 st034304 3.6505 µM 1.3225246769317 0.109562474194984 no 435 0.0929967488389962 549 4036148 YLR033W RSC58 SGTC_1914 st062367 72.6 µM 1.3217911681166 0.109687599114369 no 436 0.0931188500516703 509 978205 SGTC_1921 5740136 50 µM 1.31861641468471 0.110230344359996 no 437 0.0936486916031896 582 1774243 SGTC_2705 st078069 42.8 µM 1.31769903603609 0.110387534453201 no 438 0.0938022086947183 498 1530061 SGTC_834 0312-0008 75.7 µM 1.31733864231885 0.110449330793078 no 439 0.0938625689351875 569 6385573 YIL048W NEO1 SGTC_3348 9149464 3.537 µM 1.3167230779444 0.110554938335935 no 440 0.0939657325131626 536 1951442 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.31309861537055 0.111178226842102 no 441 0.0945748601921815 614 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1071 trifluoperazine 6.31 µM 1.31164470731818 0.111428957034325 no 442 0.0948200204867251 556 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_579 4491-1009 110 µM 1.31059389642657 0.111610423852929 no 443 0.094997501211611 672 1271041 SGTC_419 nsc-638432 893 µM 1.30933412283681 0.111828255464043 no 444 0.0952105978904523 540 368090 SGTC_2870 9038528 12.99 µM 1.30579520981122 0.112441806957944 no 445 0.0958111047490304 478 6463316 SGTC_675 1309-0189 238 µM 1.30489483031899 0.112598291382869 no 446 0.0959643309109373 538 4246530 SGTC_2290 7904846 200 µM 1.30195167565692 0.113110891685576 no 447 0.0964664528166164 548 2962154 SGTC_2832 7992762 51.95 µM 1.29289904566487 0.114697992321215 no 448 0.0980229888160997 478 2985177 SGTC_3216 9129716 49.47 µM 1.29150173815519 0.114944372088727 no 449 0.0982648763909199 512 8056934 SGTC_706 4262-0057 46.9 µM 1.29065779048927 0.115093363081474 no 450 0.0984111835868791 550 883298 SGTC_2047 4141938 200 µM 1.28957814417719 0.115284164578903 no 451 0.0985985840970021 490 3807862 SGTC_2747 doxorubicin 7.63 µM 1.28905883340848 0.115376020297002 no 452 0.0986888168863321 363 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2583 asiatic acid 100 µM 1.28663080556486 0.115806180111839 no 453 0.0991115005709665 522 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1588 farnesol 29.9 µM 1.28647942100304 0.115833037718577 no 454 0.0991378981632344 552 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.28223665372071 0.116587560109042 no 455 0.0998798209421419 601 5379071 SGTC_920 mycophenolic acid 780.421 nM 1.27777426510841 0.117384893116248 no 456 0.10066451544474 567 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2997 9067075 71.4286 µM 1.2763109627557 0.117647192630422 no 457 0.100922808199524 605 27209819 SGTC_2061 5245884 80.95 µM 1.27479988588876 0.117918490934142 no 458 0.101190040558622 580 573863 SGTC_2710 st078562 53.7235 µM 1.27455522049487 0.117962459689717 no 459 0.101233357836121 540 17250908 SGTC_2091 4-phenylthiadiazole 200 µM 1.2740424505248 0.118054647072713 no 460 0.101324186058433 581 270010 SGTC_399 oxolinic acid 75 µM 1.27255528654188 0.118322302220409 no 461 0.10158794688639 534 4628 A DNA gyrase inhibitor. SGTC_76 0433-0009 400.328 µM 1.26854829637716 0.119045602194041 no 462 0.102301107462134 481 2841569 SGTC_1027 k015-0025 8.67 µM 1.26775610879895 0.119188968437323 no 463 0.10244253036085 571 3598955 SGTC_1855 st056195 39.6 µM 1.26615219109164 0.119479610710855 no 464 0.102729300103998 559 4028379 SGTC_3299 9121982 43.1275 µM 1.26540680434389 0.119614850589213 no 465 0.102862768647449 578 17594604 YPL160W CDC60 SGTC_2558 carylophyllene oxide 100 µM 1.26528680336474 0.119636633155448 no 466 0.102884267726566 612 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2044 5102272 200 µM 1.26390133933144 0.119888325086886 no 467 0.10313272051385 519 592666 SGTC_2320 7373003 200 µM 1.26009826654475 0.120581132725902 no 468 0.103816957767585 545 5415828 SGTC_1843 st055809 45.5 µM 1.25965848003092 0.120661430323527 no 469 0.103896294729876 541 16413835 SGTC_1012 4112-3522 18 µM 1.25843330236418 0.120885325587325 no 470 0.104117547183104 573 3112398 SGTC_2476 5806916 10.51 µM 1.25622382255092 0.121289835995382 no 471 0.104517415952253 550 2870194 SGTC_653 0203-0016 55.2 µM 1.25294766242524 0.121891384211641 no 472 0.105112377247281 582 295302 SGTC_1195 1502-0147 41.1 µM 1.25286523456054 0.12190654608496 no 473 0.105127377960175 605 817940 SGTC_1727 st034309 9.9045 µM 1.25188590136476 0.122086787101773 no 474 0.105305721401242 666 870305 SGTC_2373 9071805 200 µM 1.25171344762991 0.122118545653454 no 475 0.105337149088106 583 10149009 SGTC_364 0083-0097 67.7 µM 1.25060645485657 0.122322544183196 no 476 0.105539047223183 588 5207356 SGTC_3022 9087993 49.47 µM 1.24667477489773 0.123049013892012 no 477 0.106258385851666 546 17173644 SGTC_2155 5570423 76 µM 1.24570065059424 0.123229472656405 no 478 0.10643715735954 570 797402 SGTC_1092 toremifene 6.32 µM 1.24324936822932 0.123684398626189 no 479 0.106887977816562 641 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1429 4049-0205 9.46 µM 1.24145427023407 0.124018290371043 no 480 0.107218990737695 624 22774478 SGTC_1989 st071868 50.2 µM 1.24137385260035 0.124033262955309 no 481 0.10723383688674 589 16414057 SGTC_671 0560-0003 407 µM 1.2411090125358 0.124082581234081 no 482 0.107282740311753 552 3238678 SGTC_1665 st014639 11.4 µM 1.23803544040185 0.12465594281279 no 483 0.107851460044321 641 981133 YIL048W NEO1 SGTC_1412 3909-8563 178 µM 1.23688827380428 0.124870415604927 no 484 0.108064281999498 652 23767530 SGTC_3246 9135460 32.98 µM 1.23616112842362 0.125006495200638 no 485 0.108199338233675 503 41446951 SGTC_1445 4239-0156 97.7 µM 1.23298128506574 0.125602794942361 no 486 0.108791373302731 684 4008346 SGTC_770 0389-1121 67.2 µM 1.23166588517667 0.125850044550121 no 487 0.109036959204523 649 6753108 SGTC_3111 9122088 49.47 µM 1.2311046980522 0.125955631523036 no 488 0.10914185432627 462 16876704 SGTC_1346 1488-2224 62.4 µM 1.23047185625633 0.126074774362206 no 489 0.109260229858445 619 3722427 SGTC_1763 st044482 94.5 µM 1.22719158162245 0.1266935988498 no 490 0.109875296379603 616 88505 SGTC_2774 tamoxifen 10.92 µM 1.22650759535287 0.126822899058547 no 491 0.110003859419124 585 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1396 3511-0007 98.6 µM 1.22629507635125 0.126863092178917 no 492 0.110043826764423 537 X1396 SGTC_1931 st074438 57.1 µM 1.22513670953256 0.127082326728655 no 493 0.110261857958994 566 2787313 SGTC_2442 5158906 48.48 µM 1.2237679272255 0.127341724545949 no 494 0.110519893301603 619 1893835 SGTC_2539 epi(13)torulosol 80 µM 1.22352264800913 0.127388246271869 no 495 0.110566177693368 578 6708597 SGTC_1900 st060200 72.8 µM 1.22232335118697 0.127615885219378 no 496 0.110792686051959 609 688945 SGTC_1912 st060209 90.8 µM 1.22145853709364 0.127780211274578 no 497 0.110956227637742 582 688787 SGTC_3127 9126946 49.47 µM 1.22145460560331 0.127780958645101 no 498 0.110956971501012 523 27243249 SGTC_2429 5902844 64.44 µM 1.22075770567673 0.127913486297085 no 499 0.111088885894519 634 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_606 k015-0008 38.6 µM 1.22063435534815 0.127936953453872 no 500 0.111112246254649 652 1970475 SGTC_2912 7964298 10.93 µM 1.21923476649817 0.128203432009749 no 501 0.111377549935162 668 2975850 SGTC_1415 3966-0071 78.1 µM 1.21838240847983 0.1283659077797 no 502 0.111539343453306 592 2893185 SGTC_1326 1431-2094 10.8 µM 1.21760665946825 0.128513904616732 no 503 0.11168674126973 626 616278 SGTC_2875 9039966 71.43 µM 1.21374512815412 0.12925236659874 no 504 0.112422532866152 553 6463691 SGTC_2472 5377652 49.4 µM 1.21260940004372 0.129470116806693 no 505 0.112639596637226 640 1610903 SGTC_3158 9100007 49.47 µM 1.20912588073359 0.130139587793865 no 506 0.11330724380298 532 19297233 SGTC_1490 4089-0339 670 nM 1.20752047120044 0.130448924222928 no 507 0.113615883087588 581 742542 SGTC_2211 7117706 200 µM 1.20748303238895 0.130456144138701 no 508 0.113623087827518 581 822771 SGTC_445 e6 berbamine 66 µM 1.20531666356544 0.130874389904451 no 509 0.114040539570085 733 6610268 A calcium/calmodulin antagonist. SGTC_3000 9075062 71.4286 µM 1.20504161579746 0.130927557686365 no 510 0.114093618384489 579 17057871 SGTC_11 0438-0307 1.3 µM 1.204357664043 0.13105983286531 no 511 0.114225683915322 599 4011476 SGTC_2308 7584454 197.62 µM 1.20292375132804 0.131337448896774 no 512 0.114502914107484 670 893577 SGTC_3336 9143619 71.43 µM 1.20031200082632 0.131844145726842 no 513 0.115009095353429 667 45595730 SGTC_3295 9122362 53.5725 µM 1.19748492803399 0.132394134619897 no 514 0.115558799355203 590 4730473 SGTC_3087 9117406 49.47 µM 1.19746536699095 0.13239794559525 no 515 0.115562609351019 599 42546093 SGTC_1994 st072947 40.9 µM 1.19691546250462 0.132505111537051 no 516 0.115669753340896 637 5286565 YDL195W SEC31 SGTC_1936 st074407 74.3 µM 1.19624421333456 0.132636006239521 no 517 0.11580063587439 657 809813 SGTC_2861 9024595 19.48 µM 1.19346422268043 0.133179057207655 no 518 0.116343807939407 505 16482810 SGTC_1752 st044819 83.042 µM 1.19335785072851 0.133199866544609 no 519 0.116364627406108 606 441209 YML126C ERG13 SGTC_390 dec-rvkr-cmk 16.7 µM 1.19091565924973 0.13367824314052 no 520 0.116843348237673 650 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1121 fusaric acid 630.51 nM 1.19005481791034 0.133847146009545 no 521 0.117012423531394 632 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1246 0422-0085 105 µM 1.18895851982147 0.1340624593464 no 522 0.117227995074142 675 264295 SGTC_1937 st074714 47.2 µM 1.18335861510751 0.135165994096783 no 523 0.118333525791863 612 17250970 SGTC_816 0325-0417 81.3 µM 1.17974429473353 0.135881541687771 no 524 0.119050965473945 607 68101 SGTC_1945 st075991 56.6 µM 1.17926974887252 0.135975682514858 no 525 0.119145390045185 609 1084980 SGTC_720 r052-1644 49.9 µM 1.17885899006003 0.136057205255941 no 526 0.119227165021778 560 1422863 YOR257W CDC31 SGTC_1641 st009299 47.1 µM 1.17389544004736 0.1370449592448 no 527 0.120218454577323 563 4046054 SGTC_1055 3448-0672 86 µM 1.17271294950148 0.1372809975343 no 528 0.120455468348886 634 748378 SGTC_2444 5485484 36.41 µM 1.17194988043569 0.13743346193516 no 529 0.120608589515791 667 6790631 SGTC_2175 5807670 165.306 µM 1.16865886944825 0.138092343999982 no 530 0.121270549797131 630 241186 SGTC_252 miconazole 1.30953 nM 1.16603541866568 0.138619116724899 no 531 0.121800062797113 634 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3097 9117246 49.47 µM 1.16510449610482 0.138806368879015 no 532 0.121988348576607 631 16423892 SGTC_1032 k061-1018 98.7 µM 1.16436735249051 0.138954765161941 no 533 0.122137586125572 731 4005393 SGTC_2099 5377090 177.372 µM 1.16137770463948 0.13955772603244 no 534 0.12274416588231 645 2243829 SGTC_1956 st077085 54 µM 1.15911029240489 0.140016209138621 no 535 0.123205615532816 700 24208685 SGTC_2203 7227154 166.4 µM 1.15795732773493 0.14024973697847 no 536 0.123440725433939 608 896304 SGTC_2129 girgensonine 121.053 µM 1.15740931921236 0.140360826353971 no 537 0.123552584190276 704 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3139 9095020 49.47 µM 1.15287514830688 0.141282261633863 no 538 0.124480816919967 512 25236292 SGTC_1840 st055363 71 µM 1.15259197921829 0.141339943051441 no 539 0.124538948457938 604 676033 SGTC_3086 9117350 49.47 µM 1.15081176252802 0.141702937993336 no 540 0.124904842314591 580 2679265 SGTC_489 paxilline 115 µM 1.15053444471291 0.141759541255623 no 541 0.124961907907988 609 105008 A toxic potassium channel blocker. SGTC_2327 6189656 200 µM 1.14734111144196 0.142412435040701 no 542 0.125620334578494 651 5349088 SGTC_1463 k081-0032 34.1 µM 1.1470521467861 0.142471615583576 no 543 0.125680034803988 543 977755 SGTC_2377 9073351 62.6 µM 1.14500222854743 0.142891920487573 no 544 0.126104117109002 649 7337946 YHR072W ERG7 SGTC_1556 plumbagin 1.48 µM 1.14497021703213 0.142898490605744 no 545 0.126110747477829 590 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3132 9126706 49.47 µM 1.14323352688218 0.143255238957976 no 546 0.126470822832094 640 850858 SGTC_2450 5739737 12.93 µM 1.14142474736667 0.143627434768034 no 547 0.126846605578991 637 2262825 SGTC_1494 4358-1428 177 µM 1.13731581730235 0.144475360096168 no 548 0.127703142398375 702 1564571 SGTC_3038 9091290 49.47 µM 1.13314401972476 0.145339703117781 no 549 0.128576889073204 669 25236843 SGTC_1155 4088-0394 48.2 µM 1.13183045978401 0.145612574539124 no 550 0.128852859595148 668 2326248 SGTC_3356 9151811 4.48 µM 1.12908634181696 0.146183732724991 no 551 0.129430706194764 666 1859254 YPR165W RHO1 SGTC_474 dl-dihydrosphingosine 5 µM 1.12788667550751 0.146433902244107 no 552 0.129683890905605 686 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1048 3161-0300 24.5 µM 1.12768097033756 0.146476827324545 no 553 0.129727338575432 692 2165101 SGTC_2575 plumbagin 510 nM 1.12628105813826 0.146769175292938 no 554 0.130023286404154 665 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2856 9022925 19.48 µM 1.12585880554709 0.146857432392568 no 555 0.130112644193466 685 4944862 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.12339817641686 0.147372448731078 no 556 0.130634211981407 626 17037758 SGTC_1487 3970-0795 2.82 µM 1.12279893158992 0.147498055344715 no 557 0.130761449622852 726 3765103 SGTC_3122 9126309 49.47 µM 1.11878244713059 0.148341794424711 no 558 0.131616480892286 671 17591206 SGTC_589 1227-0070 34.1 µM 1.11643287232336 0.148836861153986 no 559 0.132118444559605 702 2841384 SGTC_2614 arthonioic acid 13.39 µM 1.11357858440875 0.149439757084757 no 560 0.132730009003559 635 6710684 SGTC_565 1418-0001 44.5 µM 1.11341807100865 0.149473709814841 no 561 0.132764458680954 738 2862145 SGTC_1117 retinoic acid 1.10837 µM 1.11255814710372 0.149655693605841 no 562 0.132949121970711 761 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_672 1441-0018 53.7 µM 1.11210358786016 0.149751950672835 no 563 0.133046807139452 659 251141 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.10950708948327 0.150302574508729 no 564 0.133605743890672 674 689007 SGTC_1550 gossypolone 36.6 µM 1.10748915386637 0.150731436579825 no 565 0.134041249535847 709 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3242 9133940 49.47 µM 1.10685166282549 0.150867088650839 no 566 0.134179033714407 699 17248444 SGTC_321 4534-3890 65.3 µM 1.10235951452229 0.151825278780952 no 567 0.135152702537934 693 699746 SGTC_947 3447-0010 211 µM 1.10175055823039 0.151955481723659 no 568 0.1352850651627 700 748350 SGTC_1893 st059353 36.1 µM 1.09832643367343 0.152688985813182 no 569 0.136030986640747 698 3112488 SGTC_297 0986-0032 24 µM 1.09701012032058 0.152971585850799 no 570 0.136318484050901 679 2847425 SGTC_611 3453-1652 23.7 µM 1.09651510038338 0.153077951620006 no 571 0.136426709375872 740 1560575 SGTC_3042 9091578 49.47 µM 1.09585993025664 0.153218804492057 no 572 0.136570038402591 668 25236497 SGTC_741 4582-0002 126 µM 1.0912514056684 0.154212002157528 no 573 0.137581136939922 708 2912688 SGTC_567 1080-0542 68.4 µM 1.09122930449242 0.154216775487927 no 574 0.13758599816038 653 5950415 SGTC_120 rhodamine 6G 52.259 µM 1.08602121307084 0.155344324620209 no 575 0.138734803603953 852 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_116 0155-0182 31.788 µM 1.08287901527775 0.156027233677612 no 576 0.139431063693434 839 771486 SGTC_1220 1838-0075 193 µM 1.08202016360826 0.156214235857621 no 577 0.13962178421988 738 5529645 SGTC_1135 dihydrocapsaicin 536.708 nM 1.08154462772088 0.15631784021199 no 578 0.139727460160206 700 107982 A Capsaicinoid. SGTC_2137 5261020 140 µM 1.0787332497604 0.156931275839917 no 579 0.140353329406613 713 763655 SGTC_1756 st041558 35.5 µM 1.07862132450781 0.156955730386185 no 580 0.140378285559062 808 3955792 SGTC_93 0109-0045 59.227 µM 1.07610082786558 0.157507097518245 no 581 0.140941082734483 840 88733 SGTC_1925 st057770 10.1 µM 1.07569850313303 0.157595225067833 no 582 0.141031058555393 653 5989122 SGTC_2150 5556613 200 µM 1.07437825951265 0.157884646462367 no 583 0.141326591192227 762 743190 SGTC_3250 9135583 49.47 µM 1.07437328647927 0.157885737301079 no 584 0.141327705184059 695 7699353 SGTC_2054 5233173 129 µM 1.06810088285156 0.15926553363463 no 585 0.142737503841107 776 6889 SGTC_1673 st016611 27.3 µM 1.0647555247806 0.160004661143709 no 586 0.143493288117908 764 5226799 SGTC_2022 5136654 200 µM 1.06463559037796 0.16003120118214 no 587 0.143520433802867 711 1713771 SGTC_2746 daunorubicin 9.88 µM 1.06425909155658 0.160114534536722 no 588 0.143605672226477 612 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_712 r015-0009 80.6 µM 1.06283775882518 0.160429384620057 no 589 0.143927766444451 683 6813872 YLR060W FRS1 SGTC_3190 9110366 49.47 µM 1.06203849883468 0.160606612280383 no 590 0.144109104023019 618 17123768 SGTC_468 gf-109203x 121 µM 1.06139197408305 0.160750065999856 no 591 0.14425590141209 610 2396 A protein kinase C inhibitor. SGTC_3309 9129340 25.759 µM 1.06102807592664 0.160830846091372 no 592 0.144338571029169 794 17158987 SGTC_822 1487-0950 154 µM 1.06067121320258 0.160910090153877 no 593 0.144419673357059 742 1958375 SGTC_66 0109-0187 42.4 µM 1.0605426369126 0.160938647734712 no 594 0.144448901743243 680 759417 SGTC_1280 0880-0253 10.1 µM 1.06037021732814 0.160976948371943 no 595 0.14448810298802 755 6836607 SGTC_2361 9034121 116 µM 1.05843103595927 0.161408120498775 no 596 0.144929488129185 717 6496917 SGTC_3282 9108498 15.4605 µM 1.05831062472487 0.161434918447245 no 597 0.144956925333033 712 16459645 SGTC_408 cantharidin 100 µM 1.0579396614939 0.16151749587029 no 598 0.145041475919194 762 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2888 9058547 12.99 µM 1.05650706052773 0.161836655232196 no 599 0.145368308412881 646 16476514 SGTC_881 0833-0569 170 µM 1.05626159313357 0.161891382441468 no 600 0.145424358834321 739 5418700 SGTC_1581 himbacine 57.9 µM 1.05539752739103 0.162084122702532 no 601 0.145621776634684 756 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3353 9151644 39.2805 µM 1.05450582315454 0.162283184687027 no 602 0.145825698000145 752 4909158 SGTC_994 3910-0338 138 µM 1.05448649432408 0.162287501371876 no 603 0.145830120380886 773 3479481 SGTC_458 nppb 133 µM 1.05214917772474 0.162810042539665 no 604 0.146365556214638 727 4549 A chloride channel blocker. SGTC_2707 st078556 66.6 µM 1.0494422440044 0.163416582851795 no 605 0.146987312063902 747 17250899 SGTC_1895 st058434 18.3 µM 1.04737057905175 0.16388176922041 no 606 0.147464347782852 790 5393175 SGTC_1216 1165-0504 9.65 µM 1.04679333777861 0.164011540006869 no 607 0.147597451876942 776 6304004 SGTC_3314 9135860 59.4275 µM 1.04602286933337 0.164184854435673 no 608 0.14777523692224 783 25252478 SGTC_1997 st073024 93.8 µM 1.04212292875653 0.165063955174243 no 609 0.148677344708532 760 686268 SGTC_1922 5578187 25 µM 1.04031244223831 0.165473097766463 no 610 0.149097382726742 718 1350412 SGTC_179 1273-0063 6.77 µM 1.03833778395083 0.165920087994123 no 611 0.149556411905279 709 3108139 SGTC_49 0717-0965 32.132 µM 1.03787532765768 0.166024883817522 no 612 0.149664050676276 769 5889349 YGL099W LSG1 SGTC_2737 bleomycin 30.5 nM 1.03767204760626 0.166070962024722 no 613 0.149711381367376 815 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3240 9133527 49.47 µM 1.03730697628577 0.166153734772358 no 614 0.149796407780989 748 17617455 SGTC_2475 5812728 15.03 µM 1.0349854971489 0.166680707983567 no 615 0.150337842114803 794 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3069 9117009 49.47 µM 1.03466971359889 0.166752473745794 no 616 0.15041159236526 628 41904981 SGTC_2484 5809818 12.04 µM 1.03030147463501 0.167747255592978 no 617 0.151434253528171 739 2870548 SGTC_1384 3089-0840 101 µM 1.02874828286573 0.168101883994842 no 618 0.151798987423384 738 1069836 SGTC_2339 9000433 200 µM 1.02160355014087 0.169739394231553 no 619 0.153484288365858 681 2988954 SGTC_425 3825-7017 13.1 µM 1.02132572333119 0.169803275664931 no 620 0.153550071560009 807 3397440 SGTC_629 3448-6466 76.7 µM 1.02064172620902 0.169960614574935 no 621 0.153712106387195 792 573744 SGTC_232 clozapine 119 µM 1.01981379300205 0.170151187889615 no 622 0.153908390194914 773 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2588 indole-3-carbinol 100 µM 1.0161869135401 0.170987634465988 no 623 0.154770193475863 833 3712 Induces cell cycle arrest. SGTC_2183 6420625 130.508 µM 1.01447721669682 0.171382842817315 no 624 0.155177547733395 837 2897619 SGTC_1167 k781-0610 148 µM 1.01341245302204 0.171629265174191 no 625 0.155431596833531 827 4525169 SGTC_2860 9025725 38.96 µM 1.01228980464779 0.171889329043025 no 626 0.155699754081984 741 40546248 SGTC_3062 9077494 49.47 µM 1.01135242775071 0.172106667043021 no 627 0.155923890734454 763 16459633 SGTC_24 0417-1663 219 µM 1.0092562716117 0.172593311202545 no 628 0.156425872887604 768 4329390 SGTC_2219 9098279 200 µM 1.00857618826395 0.172751387856452 no 629 0.156588965929721 790 902349 SGTC_3261 9137475 49.47 µM 1.00815192495222 0.172850049151732 no 630 0.156690766602438 590 17027690 SGTC_422 cantharidin 155 µM 1.00790081358472 0.17290846134019 no 631 0.156751040517386 791 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3154 9100113 49.47 µM 1.00481799454257 0.173626595144767 no 632 0.157492248732262 774 25237525 SGTC_1948 st076329 66.6 µM 1.0028596698444 0.174083765450878 no 633 0.157964286929376 762 24208413 SGTC_696 1560-0013 611 µM 1.00271709669361 0.17411707896582 no 634 0.157998689263101 800 1650269 SGTC_254 nsc-64875 3.808 µM 0.998456260989334 0.175114531707117 no 635 0.159029081902084 826 56993 SGTC_1886 st057356 49.9 µM 0.998262315094135 0.17516002011784 no 636 0.15907608812814 759 24207747 SGTC_2299 7976368 114.88 µM 0.993703681908558 0.176231367718396 no 637 0.160183574848026 794 2979718 SGTC_2679 rapamycin 1 nM 0.993001477126233 0.176396764279955 no 638 0.160354617314411 878 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_773 4358-1457 44.6 µM 0.991865168385365 0.176664617183089 no 639 0.160631651207719 871 1186886 SGTC_298 1391-0729 10 µM 0.991823403020919 0.176674467093358 no 640 0.160641839622995 793 3237558 SGTC_2810 7959871 45.46 µM 0.991060542483656 0.176854440606269 no 641 0.160828009226716 865 2974535 SGTC_86 0417-1630 471.922 µM 0.991052246631506 0.176856398394475 no 642 0.160830034532568 905 3634867 SGTC_3305 9127027 53.8275 µM 0.988968407400611 0.177348610022963 no 643 0.161339299524959 812 41905295 SGTC_3249 9135183 49.47 µM 0.98780782112038 0.177623120049482 no 644 0.161623388222222 853 4902779 SGTC_708 3448-5400 146 µM 0.98740123914472 0.177719351062881 no 645 0.161722988572702 809 3462195 SGTC_2293 7624732 200 µM 0.984731237107001 0.178352111968642 no 646 0.162378052388883 752 894453 SGTC_2999 9069765 71.4286 µM 0.984418073329325 0.178426421215492 no 647 0.162454997640106 830 2097066 SGTC_762 1165-0429 115 µM 0.983398207434727 0.178668555845864 no 648 0.162705746096986 816 5967793 SGTC_1192 1488-0095 21.4 µM 0.980313393993747 0.179402205036496 no 649 0.163465722593688 788 915875 SGTC_205 1486-1330 71.903 µM 0.978080567632743 0.17993440928177 no 650 0.164017238997935 785 4118834 SGTC_665 3914-0008 307 µM 0.97788824542091 0.179980296482125 no 651 0.164064799701698 796 1069549 SGTC_740 k014-0057 261 µM 0.977309746721768 0.180118367916665 no 652 0.164207914610492 902 4012779 SGTC_495 decylubiquinone 155 µM 0.974705349047164 0.180740787878982 no 653 0.164853219431018 760 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2477 5967686 25.23 µM 0.97370042002886 0.180981314029464 no 654 0.16510265434715 804 776118 SGTC_1303 1160-0052 261 µM 0.969946020319632 0.181881689397911 no 655 0.166036699644757 843 3562476 SGTC_2489 cantharidin 73.42 µM 0.968433370078798 0.182245241647919 no 656 0.166413990219601 818 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_136 0097-0015 404.482 µM 0.966034697655866 0.182822671902877 no 657 0.167013409499313 918 4861337 SGTC_3078 9116413 49.47 µM 0.965230916902307 0.183016420495719 no 658 0.167214582380371 793 17177322 SGTC_2921 7974240 10.71 µM 0.96380733450661 0.183359884393205 no 659 0.167571264397484 821 2979074 YDR527W RBA50 SGTC_891 0929-0073 133 µM 0.963487655723176 0.18343706765474 no 660 0.167651428026539 851 5603632 SGTC_556 4058-0063 51.5 µM 0.963479743924919 0.183438978136503 no 661 0.167653412326411 872 6615692 SGTC_51 1013-0126 23.419 µM 0.962190244283232 0.183750522591185 no 662 0.167977024368138 807 1627850 SGTC_2566 crystal violet carbinol 226 nM 0.958988444815527 0.184525504896717 no 663 0.16878228319819 702 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_956 1185-0240 191 µM 0.958853825390625 0.184558133441665 no 664 0.168816194499053 823 1416193 SGTC_1383 3049-0032 20.7 µM 0.956545042217363 0.185118285883231 no 665 0.169398469732445 876 712864 SGTC_1781 st038725 66.3 µM 0.954513202434012 0.185612119506308 no 666 0.169911964818004 897 4270275 YIL048W NEO1 SGTC_290 2043-6722 48.1 µM 0.946504987891109 0.187566444993947 no 667 0.171945539703448 854 773758 YLR208W SEC13 SGTC_563 tetrahydrosecaminediol 614 µM 0.945619708838947 0.187783266348812 no 668 0.172171294037 901 334274 A psychoactive constituent of the cannabis plant. SGTC_2956 9076196 2.52 µM 0.943623122014277 0.188272835666588 no 669 0.172681136128704 873 16423868 SGTC_623 k072-0108 16.9 µM 0.940878032695451 0.188947224413655 no 670 0.173383683090471 850 5382803 SGTC_2417 cerulenin 830 nM 0.937422937497005 0.189798153346805 no 671 0.17427052335492 848 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_976 1348-1067 47.6 µM 0.936696710432393 0.189977309513275 no 672 0.174457294423442 937 5310671 YGL099W LSG1 SGTC_1359 1582-0056 520 nM 0.927493102721338 0.192256785380605 no 673 0.176835285619443 939 3661189 SGTC_2665 lovastatin 100 µM 0.924710788074669 0.192949166456991 no 674 0.177558183148011 862 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_796 1234-0020 70.7 µM 0.923560511179195 0.193235858096304 no 675 0.17785759081525 851 46495034 SGTC_2451 5856223 45.7 µM 0.9211707204939 0.19383231313423 no 676 0.178480651130532 857 2179896 SGTC_2056 5235370 200 µM 0.920091474079424 0.194102043893958 no 677 0.178762479696209 828 5511916 SGTC_294 k038-0071 157 µM 0.919442771875363 0.194264280820956 no 678 0.178932013008756 886 24152826 SGTC_2149 5554786 194.827 µM 0.916320311604977 0.195046346031588 no 679 0.179749458856058 911 745063 YPR165W RHO1 SGTC_2148 5546263 113.568 µM 0.914433686586901 0.195519804716557 no 680 0.180244503884302 896 792097 SGTC_1964 st076914 61 µM 0.91247011596406 0.196013313818564 no 681 0.180760647005365 930 24208661 SGTC_2241 6772625 37.8075 µM 0.911988300805708 0.196134524982481 no 682 0.180887438118322 854 2285411 SGTC_344 k064-0035 6.43 µM 0.911916729355391 0.196152534226491 no 683 0.180906277115281 860 5088750 SGTC_3263 9137018 49.47 µM 0.911162266733114 0.196342437700006 no 684 0.181104941138386 851 43844957 SGTC_1202 1988-0068 29.6 µM 0.910886631266407 0.196411844844654 no 685 0.181177555150886 880 2850480 SGTC_466 geldanamycin 89.2 µM 0.9096263260548 0.196729388852205 no 686 0.181509804995204 803 5288382 HSP90 inhibitor. SGTC_619 1652-1634 108 µM 0.908311671562618 0.197060957717662 no 687 0.18185678886717 840 5400454 SGTC_2658 polymyxin b sulfate 77.05 µM 0.9063876171053 0.197546832543256 no 688 0.182365362335755 912 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2662 daunorubicin 22.37 µM 0.905608002701749 0.197743911880104 no 689 0.182571685745828 869 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2773 thioridazine 9.09 µM 0.903428681700779 0.198295454073454 no 690 0.183149211683405 952 5452 An antipsychotic. SGTC_69 0096-0274 206.684 µM 0.901693721563582 0.19873520058222 no 691 0.183609794554586 963 6741392 SGTC_3135 9127742 49.47 µM 0.900545049079322 0.199026668689515 no 692 0.183915131399336 853 3643468 SGTC_151 3013-0144 2.285 µM 0.899805758908455 0.199214394882338 no 693 0.184111814553763 906 906558 YHR107C CDC12 SGTC_2330 7979373 200 µM 0.897885472737382 0.199702506607535 no 694 0.184623305158975 882 1863007 SGTC_3319 9138450 16.7555 µM 0.8971342799371 0.199893645656124 no 695 0.184823634319579 858 2029690 SGTC_870 0573-2213 57.6 µM 0.896404418694082 0.200079462282541 no 696 0.18501840410383 904 3916321 SGTC_13 0199-0087 65 µM 0.895710388230317 0.200256252967087 no 697 0.185203730371941 969 4589825 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.895441577763232 0.200324752386507 no 698 0.185275541528188 998 91467 include heat shock SGTC_473 2-arachidonoylglycerol 10 µM 0.895007001244718 0.200435522782515 no 699 0.185391672687632 874 5282280 An endocannabinoid. SGTC_1680 diphenhydramine 100 µM 0.8936122065435 0.200791294267096 no 700 0.185764706525099 889 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2289 7946404 165.07 µM 0.892793790912944 0.201000224567835 no 701 0.185983806027623 962 1246120 YPR165W RHO1 SGTC_2014 4013930 200 µM 0.891790387658232 0.201256557560463 no 702 0.186252647431125 978 64556 SGTC_1574 spiramycin 23.7 µM 0.889960873230871 0.201724436022051 no 703 0.186743447873389 948 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1455 4262-0120 131 µM 0.888832317988882 0.202013376365664 no 704 0.187046602153231 953 1529587 SGTC_1910 st062352 60.4 µM 0.884457553033347 0.203135772257571 no 705 0.18822463323412 951 2245730 SGTC_504 lovastatin 124 µM 0.884347066677816 0.203164166907447 no 706 0.188254444005319 871 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1771 st048882 4.1505 µM 0.884306841512325 0.203174505238222 no 707 0.188265298043496 925 4580403 SGTC_1355 1499-0035 1.68 µM 0.88416159849435 0.203211836980496 no 708 0.188304492476215 897 1548538 SGTC_1163 k060-0048 49.9 µM 0.882933868824791 0.203527563284723 no 709 0.188636001523054 961 6809982 SGTC_2854 9024559 71.43 µM 0.88262786405305 0.203606301831599 no 710 0.188718684284431 898 3163529 SGTC_2342 7990637 118.86 µM 0.882307185543632 0.203688835590016 no 711 0.188805355869597 945 2033102 YER133W GLC7 SGTC_23 0213-0011 39.996 µM 0.879018116332799 0.204536501757329 no 712 0.189695726578041 934 627608 SGTC_1719 st032227 49.2 µM 0.878702115508816 0.20461805256984 no 713 0.189781405662054 936 3125804 SGTC_274 sirtinol 40.1 µM 0.877845202116299 0.2048392948477 no 714 0.190013865159311 929 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_67 0335-0847 266 µM 0.877723443472271 0.204870742654959 no 715 0.190046909475176 1020 4552207 YOR254C SEC63 SGTC_3164 9100705 49.47 µM 0.877421917258953 0.204948633164101 no 716 0.190128756464203 923 17174235 SGTC_2768 sulfasalazine 50.2 µM 0.875922517285182 0.205336220819286 no 717 0.19053607871633 961 5384001 An antioxidant and salicylic acid derivative. SGTC_1115 galangin 695.678 nM 0.873730246236545 0.205903695294793 no 718 0.191132587588229 1027 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_465 cgp-37157 41 µM 0.873367517264347 0.205997678155028 no 719 0.191231395093231 842 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1016 4226-1401 38 µM 0.872777213509914 0.206150679886682 no 720 0.191392260981893 939 2901613 SGTC_1838 st055369 84.5 µM 0.872167648465953 0.206308744667922 no 721 0.191558462838258 967 676036 SGTC_2321 7390090 138.78 µM 0.871056589643352 0.206597035249143 no 722 0.191861627575572 853 649046 SGTC_1495 4469-0029 237 µM 0.870877828514001 0.206643441339011 no 723 0.191910431950967 1011 793680 SGTC_330 1488-0319 80.1 µM 0.870493886357654 0.206743132944855 no 724 0.192015279401415 923 6846614 SGTC_3058 9093861 49.47 µM 0.869342552930148 0.20704225041686 no 725 0.192329897227198 932 17217477 SGTC_1637 st007924 17.4 µM 0.86914243523616 0.207094267283798 no 726 0.192384614305213 903 683336 SGTC_552 k242-0005 476 µM 0.865835856478116 0.207954869539137 no 727 0.19329009139059 934 4088318 SGTC_539 4859-0462 2.54 µM 0.863640745976274 0.208527354623921 no 728 0.19389263673208 978 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1633 st005664 67.9 µM 0.863424428591256 0.208583820479044 no 729 0.193952076524369 984 2063822 SGTC_1967 st070177 51.4 µM 0.862953187176446 0.20870686097977 no 730 0.194081602899076 934 5729214 SGTC_1804 st050076 49.1 µM 0.861843932419935 0.208996654709688 no 731 0.194386702869254 947 3895976 SGTC_847 0342-0274 5.54 µM 0.861045752838673 0.209205326335739 no 732 0.194606422309922 995 18097 SGTC_3034 9090421 49.47 µM 0.858921719747168 0.209761218850455 no 733 0.195191852746996 917 17173761 SGTC_199 4063-0024 41.6 µM 0.858208851860541 0.209947981935653 no 734 0.195388574517351 990 306215 SGTC_292 k038-0015 474 µM 0.855918096046195 0.210548794466912 no 735 0.196021542348758 957 46368540 SGTC_175 3793-3120 23.7 µM 0.851838615865341 0.21162124311341 no 736 0.197151835165723 931 5322297 SGTC_2890 9046729 58.44 µM 0.851064081062204 0.211825220039174 no 737 0.197366878455494 889 903329 SGTC_2859 9028643 45.46 µM 0.850697204972654 0.211921878501563 no 738 0.197468788111086 934 17151580 SGTC_2366 9070441 60.58 µM 0.848320175311914 0.212548763908595 no 739 0.19812984231505 1024 6837235 SGTC_1047 2043-3044 82 µM 0.847013068288988 0.212893943565466 no 740 0.198493918698617 1028 669592 SGTC_1038 k292-0204 154 µM 0.846137655312936 0.213125304658528 no 741 0.198737978256157 911 4454212 SGTC_2278 7948257 134.34 µM 0.845600523608669 0.213267334661097 no 742 0.198887816678465 987 1247028 SGTC_730 1436-0052 41.2 µM 0.842008123026319 0.21421866610915 no 743 0.199891703320776 971 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_704 1310-0270 142 µM 0.839439551194649 0.214900380649471 no 744 0.200611348595752 1031 5718033 SGTC_1923 st058458 19.1 µM 0.839272311812988 0.21494481064607 no 745 0.200658258483797 1043 3534982 SGTC_187 1488-2104 32.728 µM 0.838002971810836 0.215282206354587 no 746 0.201014517222427 1031 2852859 SGTC_1996 st072960 66.8 µM 0.83721264228726 0.215492434299456 no 747 0.201236526243555 1014 1719405 SGTC_1860 st056228 74.6 µM 0.835771265258128 0.215876147575485 no 748 0.201641797354261 965 688679 SGTC_2531 methyl deoxycholate 70.07 µM 0.835649707091193 0.215908526031165 no 749 0.201675998130699 955 16667744 Haematoxylin. SGTC_1687 st020778 55.3625 µM 0.835133219525099 0.216046129978698 no 750 0.20182135228818 1049 4259299 SGTC_613 3914-0030 117 µM 0.83418579548025 0.216298677148615 no 751 0.202088147129564 794 1145395 SGTC_1987 st072290 61.9 µM 0.833612415710641 0.216451601335159 no 752 0.202249713476434 1015 54697379 SGTC_1232 0279-0259 161 µM 0.833188523351135 0.216564696452428 no 753 0.202369207080456 982 1560000 SGTC_2521 angolensin 13.4 µM 0.832946289750525 0.216629340087286 no 754 0.202437510741426 962 821428 A flavenoid. SGTC_3093 9117344 49.47 µM 0.831493005998652 0.217017404731457 no 755 0.202847588829384 943 24824913 SGTC_518 1021-0119 62.6 µM 0.828410876992875 0.217841741671463 no 756 0.203718924339598 912 1097762 SGTC_3232 9132874 49.47 µM 0.828000673722619 0.217951589412464 no 757 0.20383505917374 972 3784940 SGTC_1361 1608-0041 5.61 µM 0.827788664889197 0.218008375468707 no 758 0.203895097589221 994 X1361 SGTC_1080 nisoldipine 24.4 µM 0.824301223508988 0.218943701692405 no 759 0.204884211792408 1025 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2352 9027995 87.8 µM 0.823332324153533 0.219203968104887 no 760 0.205159518329708 941 2997347 SGTC_1314 1222-0010 41.1 µM 0.822260638144567 0.219492052187939 no 761 0.205464286936764 1002 3526027 SGTC_2400 5203494 178.7 µM 0.821831643971187 0.219607432708451 no 762 0.205586360625969 949 6777674 SGTC_3094 9117742 49.47 µM 0.82134683381913 0.219737867181834 no 763 0.205724369004889 1053 17149698 SGTC_2033 5192550 145 µM 0.820056403981842 0.220085264150828 no 764 0.206091976772023 1010 182073 SGTC_283 0987-0079 11.7 µM 0.820015227538894 0.220096354456651 no 765 0.206103713210676 1053 411556 SGTC_684 1140-0066 328 µM 0.81864852290454 0.220464639316472 no 766 0.206493487109816 1056 6813534 SGTC_1358 1509-0022 2.48 µM 0.816192775254098 0.221127274402174 no 767 0.207194944151901 1035 3258434 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.815493712686212 0.221316110810484 no 768 0.207394881010444 988 803109 SGTC_29 0299-0004 12.984 µM 0.815416118725458 0.221337076800821 no 769 0.207417080464705 918 16871 A napthoquinone isolated from Swertia calycina. SGTC_2479 5617353 43.85 µM 0.814850650521717 0.221489901349725 no 770 0.207578902035298 993 2731746 SGTC_1941 st076221 61.8 µM 0.811103284171919 0.222504195157226 no 771 0.208653180005414 1047 2828568 SGTC_230 MPP+ 141.667 µM 0.810087971723679 0.222779463540622 no 772 0.208944808435114 978 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_273 hydroxyurea 18.1 mM 0.809844759668238 0.222845431242959 no 773 0.20901470191926 1082 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3322 9139058 2.11 µM 0.809392906125532 0.222968019429572 no 774 0.209144590659972 1013 4908926 YPR165W RHO1 SGTC_2214 7179297 48.276 µM 0.807635471587915 0.223445177724196 no 775 0.209650230279406 1043 769744 SGTC_896 0964-0007 44.5 µM 0.807468022181412 0.223490671943156 no 776 0.209698445406375 1068 6756758 SGTC_222 nsc-310342 10.666 µM 0.807251600720275 0.223549479152643 no 777 0.209760771130574 996 432556 SGTC_1345 1488-0192 31.4 µM 0.806293200810817 0.22381000651777 no 778 0.210036904986394 1071 658348 SGTC_1079 idarubicin 2.36 µM 0.805521601586751 0.224019880119743 no 779 0.210259373007044 1009 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1457 k015-0032 57.3 µM 0.802944764347218 0.22472158482153 no 780 0.211003330509276 1006 4302660 SGTC_2144 5628481 200 µM 0.80279865097218 0.2247614106127 no 781 0.211045561014762 1026 2818399 SGTC_755 1995-0008 37.3 µM 0.80218826341915 0.224927825839884 no 782 0.21122203221209 1078 689533 SGTC_1164 k060-0068 93.7 µM 0.80140236959529 0.225142193672178 no 783 0.211449371893295 1091 5963676 SGTC_246 cycloheximide 667 µM 0.800503361795703 0.22538755741157 no 784 0.211709608285433 944 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3202 9113761 49.47 µM 0.800418637728798 0.225410688723084 no 785 0.211734143079224 1067 4798415 SGTC_414 piperonyl butoxide 100 µM 0.800338463542379 0.225432579066708 no 786 0.21175736182947 1023 5794 A potent inhibitor of cytochrome P450. SGTC_506 n9-isopropylolomoucine 153 µM 0.800204648971274 0.225469117782944 no 787 0.211796118358338 1040 6610355 SGTC_615 k087-0205 167 µM 0.799156804634242 0.225755352630237 no 788 0.212099747533531 1019 9642773 SGTC_1683 st010134 710 nM 0.799110820646101 0.225767918572393 no 789 0.21211307793556 1056 3818134 SGTC_2988 9073640 71.4286 µM 0.799052444063775 0.225783871581119 no 790 0.212130001560328 1006 9102229 SGTC_2683 piperine 63.03 µM 0.798197137242886 0.226017680818304 no 791 0.212378049228245 1011 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1977 st070720 65.3 µM 0.796778072873498 0.226405902263365 no 792 0.212789965965454 984 682188 SGTC_2337 9009472 200 µM 0.793916224773588 0.227189978598188 no 793 0.213622101792986 1050 5742383 SGTC_1190 1486-1332 13 µM 0.7938026332075 0.227221131453975 no 794 0.213655169736243 1035 4150046 SGTC_2576 guaiol 23.12 µM 0.793631609946787 0.227268039679232 no 795 0.213704962397389 1071 227829 SGTC_1390 3413-2614 145 µM 0.793213269120151 0.227382805113516 no 796 0.21382678895269 1104 3421432 SGTC_3289 9119912 71.43 µM 0.791288536824633 0.227911246561621 no 797 0.214387818084469 1053 17014829 SGTC_2034 5197015 53.07 µM 0.790485790067702 0.228131847282121 no 798 0.214622058849575 1028 780676 SGTC_293 4049-0273 38.5 µM 0.790467669144656 0.228136828430569 no 799 0.214627348234547 991 1380311 SGTC_931 2812-0076 566 µM 0.789727502119892 0.228340340622879 no 800 0.214843463138865 1096 3450959 SGTC_1366 1683-0113 21.9 µM 0.788899605246574 0.228568095360756 no 801 0.215085343229596 1086 708623 SGTC_1844 rapamycin 4 nM 0.788414718557848 0.228701547097424 no 802 0.215227082130031 1081 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1678 st019265 80.2 µM 0.78800563510962 0.228814170091987 no 803 0.215346704873695 1089 5367020 SGTC_2842 9000675 19.48 µM 0.787552094678502 0.228939068728423 no 804 0.21547937265424 1042 2989072 SGTC_3030 9087619 49.47 µM 0.786786128127039 0.229150091950155 no 805 0.215703537646838 1073 25236973 SGTC_1738 st035555 74 µM 0.786752184605882 0.229159445888874 no 806 0.215713474561884 1059 5331140 SGTC_1513 0337-0559 19 µM 0.786455401805581 0.229241240518042 no 807 0.215800368585849 983 775073 SGTC_1721 st082152 9.2685 µM 0.783747455288244 0.229988318020792 no 808 0.216594155541158 1050 5296051 SGTC_1669 st015249 58.4 µM 0.783743222447073 0.229989486857036 no 809 0.216595397644925 1162 722793 SGTC_1313 1220-0047 237 µM 0.783107524594246 0.230165063117321 no 810 0.216781986428778 1085 3528706 SGTC_41 0478-0632 82.643 µM 0.779257011273636 0.231230154853541 no 811 0.217914166258781 1117 3750424 SGTC_633 0437-0093 97.7 µM 0.779219005310944 0.231240681381294 no 812 0.21792535825154 1103 2831118 SGTC_2617 dihydrotanshinone i 20.83 µM 0.778887479085875 0.231332515677932 no 813 0.218023000122261 1110 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2808 7946468 45.46 µM 0.778588647251099 0.231415310905699 no 814 0.218111034374566 1062 2970879 SGTC_3115 9123671 49.47 µM 0.77569845701156 0.232216927707131 no 815 0.218963525572765 1177 3286988 SGTC_2254 7938975 95.19 µM 0.775004314820482 0.232409683327991 no 816 0.219168554975898 1110 2969277 SGTC_140 0062-0056 502.533 µM 0.774401247104076 0.232577220792402 no 817 0.219346773195264 1117 3758964 SGTC_2507 purpurin 79.67 µM 0.773398609749457 0.232855910739917 no 818 0.219643256248945 1103 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_192 3455-0609 60.9 µM 0.772659319071328 0.233061520444706 no 819 0.219862014173508 1092 3769639 SGTC_3209 9113616 49.47 µM 0.772428662127924 0.233125690813345 no 820 0.219930291713591 1106 16649353 SGTC_2312 7706453 155.7 µM 0.772399346684262 0.233133847276533 no 821 0.219938970348384 1053 976098 SGTC_1256 0570-0116 285 µM 0.771377909048162 0.233418141730942 no 822 0.220241482601677 1071 410638 SGTC_2204 7233102 200 µM 0.770478352726844 0.233668672421205 no 823 0.220508095563907 1027 2172480 SGTC_3281 9140613 49.47 µM 0.769539894608217 0.233930196257107 no 824 0.220786435360097 1045 16013766 SGTC_2667 digitoxin 100 µM 0.768942800872454 0.234096675105554 no 825 0.220963633660654 1052 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.767148919634933 0.234597231028292 no 826 0.221496489560413 1132 4174840 SGTC_2689 tacrolimus 100 µM 0.764884614077328 0.235229896153693 no 827 0.22217012827053 1062 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3106 9121286 49.47 µM 0.764815497309903 0.235249222738632 no 828 0.22219070912026 1088 15943471 SGTC_1466 k213-0079 57.5 µM 0.76402135409134 0.235471345736685 no 829 0.222427258625877 1077 3657981 SGTC_158 k038-0087 26.446 µM 0.763939202646271 0.235494330217237 no 830 0.222451737071719 1088 X158 SGTC_2049 5262831 67.185 µM 0.763859672926359 0.235516582366024 no 831 0.222475435792668 1084 763417 SGTC_1299 1079-1439 3.74 µM 0.763519628355982 0.235611738779338 no 832 0.222576780456631 1091 323161 SGTC_2368 9071271 200 µM 0.763335473443307 0.235663280642767 no 833 0.222631675769747 1082 27209959 SGTC_2506 ethyl hematommate 54.16 µM 0.762695997182356 0.235842307576597 no 834 0.222822359168121 1047 3940691 An allergen. SGTC_323 4013-0906 34.3 µM 0.762005281259477 0.236035763697125 no 835 0.22302842606104 1118 2910086 SGTC_1540 guanosine 70.6 µM 0.761173719155314 0.236268784053024 no 836 0.223276656661933 1053 6802 Guanosine is a purine nucleoside SGTC_2096 5468907 200 µM 0.760831408027119 0.236364743280744 no 837 0.223378886037529 1113 759785 SGTC_699 0375-0592 111 µM 0.760607123277583 0.236427628099853 no 838 0.223445881910041 1137 762578 SGTC_3188 9110789 49.47 µM 0.759283118751174 0.236799039246998 no 839 0.223841606819862 1104 849217 SGTC_2458 5808907 16.39 µM 0.758810352553875 0.236931737815896 no 840 0.223983005929717 1174 2731747 SGTC_1995 st072814 61.1 µM 0.757110748681152 0.23740912927344 no 841 0.224491757490323 1055 5769371 SGTC_2223 6903751 107.57 µM 0.755979976981709 0.237727037228389 no 842 0.224830600397556 1043 5598863 SGTC_2122 5258151 111.688 µM 0.748678753862713 0.239785332391079 no 843 0.227025426130059 1097 2173356 SGTC_3197 9113331 49.47 µM 0.747552606679768 0.240103668936071 no 844 0.227365030194012 1117 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1981 st071826 47 µM 0.746703954730845 0.240343715944348 no 845 0.227621141020745 1081 11838600 SGTC_1168 k815-0004 80.5 µM 0.746615377388644 0.240368778184437 no 846 0.227647881733645 1119 642433 SGTC_1703 st026983 48.3 µM 0.746407744216679 0.240427531884735 no 847 0.227710571275503 1131 1104023 SGTC_1244 0416-0015 52.5 µM 0.745726349276694 0.240620400306312 no 848 0.22791636936054 1117 96201 SGTC_1807 st050092 58.9 µM 0.745452073409521 0.24069805769068 no 849 0.227999236968026 1101 5008496 SGTC_3210 9128157 49.47 µM 0.744500934144314 0.240967465143301 no 850 0.22828673814299 1038 17590849 SGTC_1377 2944-0135 198 µM 0.742843438439455 0.241437337675023 no 851 0.22878823652747 1134 1894137 SGTC_2663 amphotericin b 100 µM 0.742555635562044 0.241518975696639 no 852 0.228875378264692 1121 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1209 2323-2347 50.3 µM 0.742499457274626 0.241534912950358 no 853 0.228892390251901 1132 5412760 SGTC_638 3970-0837 4.09 µM 0.742250525740492 0.241605539365487 no 854 0.228967780584126 1134 4118451 YLR208W SEC13 SGTC_3201 9113999 49.47 µM 0.741907592168899 0.241702854233263 no 855 0.22907166278355 1075 16649224 SGTC_115 0527-0192 112.043 µM 0.740377625018914 0.242137274813617 no 856 0.229535445789504 1143 4233931 SGTC_1885 st057546 99.9 µM 0.738717718514284 0.242609068896093 no 857 0.23003921215125 1153 702008 SGTC_3136 9095672 49.47 µM 0.73752447633299 0.242948530585783 no 858 0.230401732086284 986 17217380 SGTC_16 erodoxin 22.806 µM 0.736819025526751 0.243149342851834 no 859 0.230616205846753 1183 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_754 3474-0146 171 µM 0.736621907437083 0.243205470145041 no 860 0.230676154351068 1103 24762078 SGTC_1253 0550-0034 176 µM 0.736388327183907 0.243271988720551 no 861 0.230747203173924 1084 5969915 SGTC_176 1486-1328 72.834 µM 0.735999154317445 0.243382838525869 no 862 0.230865606224089 1140 22310231 SGTC_2753 fluvastatin 17.09 µM 0.735569421653681 0.243505272856742 no 863 0.230996388706981 1118 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1093 fluphenazine 7.97 µM 0.734311939769904 0.2438637307092 no 864 0.231379321320446 1202 6602611 An atypical antipsychotic. SGTC_348 k064-0012 10.7 µM 0.73308844145176 0.244212774344989 no 865 0.231752244692394 1099 5066323 SGTC_1961 st076550 68.7 µM 0.731897076410892 0.244552909556604 no 866 0.232115695384541 1090 1579337 SGTC_1783 st039459 87.517 µM 0.731716432827396 0.244604505644336 no 867 0.232170832155388 1185 729761 SGTC_979 1426-2828 121 µM 0.731627175096927 0.244630001931033 no 868 0.232198078454108 1181 747872 SGTC_554 4483-2211 187 µM 0.727877483701696 0.245702385370024 no 869 0.233344293791124 1107 747107 SGTC_47 0149-0135 24.25 µM 0.726275099850344 0.246161423725329 no 870 0.233835070450709 1126 5239155 SGTC_1691 st019933 84.6 µM 0.724703352968134 0.246612131877697 no 871 0.234317018849968 1140 6176082 SGTC_353 1988-1175 58.3 µM 0.724570724980284 0.2466501839869 no 872 0.234357712016202 1064 2788357 SGTC_25 0118-0223 35.662 µM 0.724286801816538 0.246731654552118 no 873 0.234444838996651 1183 5333628 SGTC_643 k048-0106 28.4 µM 0.723941767446204 0.24683068011451 no 874 0.234550743179726 1147 6763920 SGTC_371 0195-0006 7.36 µM 0.722954032252141 0.247114279702469 no 875 0.234854062967799 1043 3928593 SGTC_1734 st037168 69.4 µM 0.7217757422033 0.247452819443975 no 876 0.235216182906495 1086 708907 SGTC_2423 st077119 87.2 µM 0.720478971709418 0.247825686617555 no 877 0.23561507116262 1152 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2928 9011484 9.79 µM 0.720167603679959 0.247915260522745 no 878 0.235710903888458 1133 2994751 SGTC_1776 st049249 45.9 µM 0.719042537716629 0.24823906183748 no 879 0.236057355326712 1182 1822314 SGTC_2919 7978188 46.38 µM 0.71898812628269 0.248254727517625 no 880 0.236074117826859 1149 2980291 SGTC_669 0108-0021 26.2 µM 0.717783883517455 0.248601577813171 no 881 0.236445276050065 1229 17201 SGTC_2883 9059145 45.46 µM 0.71667026912096 0.248922554594996 no 882 0.236788787457176 1169 16476510 SGTC_601 0986-0029 62.9 µM 0.714878815061825 0.249439367375203 no 883 0.237341964276843 1158 24747981 SGTC_3187 9109394 49.47 µM 0.71475105375115 0.249476246737154 no 884 0.237381442335241 1138 17098090 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.712881780997683 0.250016158985194 no 885 0.237959456970488 1168 616764 SGTC_2319 6033012 152.6 µM 0.711855615485827 0.250312815356928 no 886 0.238277094597205 1125 847246 SGTC_2407 paclitaxel 400 µM 0.710511181431011 0.25070176289389 no 887 0.238693599795675 1174 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2585 alliin 100 µM 0.710077987581206 0.250827154910834 no 888 0.238827887907818 1231 87310 A garlic compound which reacts with lipids. SGTC_538 2922-0838 53.3 µM 0.709827316330537 0.250899729214502 no 889 0.238905613719885 1212 777039 SGTC_14 0354-0009 295 µM 0.706216444022151 0.251946380419074 no 890 0.240026772846141 1219 1713507 SGTC_1154 4088-0362 150 µM 0.705206786677633 0.252239452437333 no 891 0.240340779222592 1214 6618304 SGTC_3292 9120825 59.784 µM 0.704341181799078 0.252490853570426 no 892 0.24061016293699 1211 24824900 SGTC_625 k213-0058 121 µM 0.70415963775512 0.252543596887387 no 893 0.240666681856291 1250 3655420 SGTC_431 k089-0097 107 µM 0.701938947643173 0.253189235228975 no 894 0.241358619261547 1161 5499420 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.699814976918937 0.25380756479684 no 895 0.242021430149076 1210 5357218 A potent inhibitor of glutathione S-transferases. SGTC_863 0466-0191 129 µM 0.698952504080141 0.254058873692273 no 896 0.24229085683067 1210 765160 YPR165W RHO1 SGTC_1309 pyrazolanthrone 13.4 µM 0.698656948612315 0.254145023200818 no 897 0.242383222371076 1218 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3146 9095609 49.47 µM 0.698079865396691 0.254313277523373 no 898 0.242563624556347 1195 17173999 SGTC_1491 4138-0063 26.5 µM 0.697432093991363 0.254502211225042 no 899 0.242766211190652 1165 23883227 SGTC_846 0335-0850 148 µM 0.693983476281088 0.255509296671194 no 900 0.243846285708777 1182 6819598 SGTC_2256 7954252 200 µM 0.692986890319079 0.255800712787816 no 901 0.244158889327913 1156 2972920 SGTC_1224 0823-0416 294 µM 0.691346315280879 0.256280818221656 no 902 0.244673966221663 1226 3598164 SGTC_1827 berberine 7.24 µM 0.689466444875238 0.256831529090401 no 903 0.245264891174027 1138 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2798 7813637 45.45 µM 0.688958961987046 0.256980302473378 no 904 0.245424546515881 1193 956368 SGTC_502 l-744,832 89.3 µM 0.688735810519704 0.25704573561392 no 905 0.245494768180172 1164 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_949 1165-0505 146 µM 0.688168764699099 0.257212045464979 no 906 0.245673255631205 1231 6244267 SGTC_1689 st020265 53.493 µM 0.686629885071936 0.257663667886994 no 907 0.246157995509977 1194 5758320 YPR016C TIF6 SGTC_1847 st056231 15 µM 0.686073862707156 0.257826947646437 no 908 0.246333266016222 1238 5393180 SGTC_1462 k081-0014 26.5 µM 0.685280049127589 0.258060149436255 no 909 0.246583609436462 1017 3270634 SGTC_3206 9114350 49.47 µM 0.685200453035159 0.258083538731345 no 910 0.246608719014472 1152 17087243 SGTC_279 1273-0055 2.93 µM 0.683218615276703 0.258666255587237 no 911 0.247234355739058 1256 2847562 SGTC_161 4065-0411 162.148 µM 0.682204621765129 0.258964661798256 no 912 0.247554786318527 1213 1906281 YLR208W SEC13 SGTC_1908 st060353 56.5 µM 0.681717775246731 0.259107998173008 no 913 0.24770871276061 1246 4227716 SGTC_3306 9127676 59.7925 µM 0.68134514257636 0.259217735642744 no 914 0.247826562690613 1218 41905287 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.680647107760706 0.259423366181599 no 915 0.248047405808438 1242 364106 SGTC_387 norethindrone acetate 66.7 µM 0.678578609332357 0.260033209079062 no 916 0.248702450050316 1213 541197 SGTC_962 1254-0300 21.5 µM 0.673795537555366 0.261446198794055 no 917 0.25022065615187 1192 7340576 SGTC_3096 9117468 49.47 µM 0.672658880013424 0.261782562999576 no 918 0.250582166712306 1141 41316311 SGTC_830 4076-0286 57.8 µM 0.670547057662343 0.262408090683568 no 919 0.251254559461583 1276 6866659 SGTC_1325 1431-0015 227 µM 0.670410648762315 0.262448521679517 no 920 0.25129802409197 1185 1103340 SGTC_3283 9109332 35.8195 µM 0.670005985117549 0.262568480959469 no 921 0.251426987419894 1138 17027281 SGTC_742 0kpi-0133 140 µM 0.666595974266237 0.26358046460646 no 922 0.252515120625373 1250 2728852 SGTC_500 h-89 112 µM 0.666441326390988 0.263626406347449 no 923 0.252564527455216 1275 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1031 k035-0009 16 µM 0.665625657860987 0.263868787197364 no 924 0.25282520109543 1256 5180959 SGTC_3248 9135562 49.47 µM 0.665379275591883 0.26394202351808 no 925 0.252903968476712 1270 17650701 SGTC_2165 5727197 32.143 µM 0.664630583115588 0.264164633457089 no 926 0.253143401564742 1370 1361712 SGTC_3198 9112019 49.47 µM 0.663308986337555 0.264557819219681 no 927 0.253566341196112 1280 45595555 SGTC_731 3966-0296 387 µM 0.66214987856161 0.264902908099141 no 928 0.253937586156221 1273 660956 SGTC_1304 1165-0502 251 µM 0.661719973429208 0.265030957336132 no 929 0.254075350848502 1255 767425 SGTC_2555 cholic acid 100 µM 0.660289828919343 0.265457158695724 no 930 0.254533927956997 1258 6708657 Influences liver metabolism. SGTC_542 3381-0244 89.3 µM 0.656024345601344 0.266730389296755 no 931 0.255904229962849 1266 1112843 SGTC_1865 st057639 52.2 µM 0.655672194121765 0.26683564294773 no 932 0.256017531689782 1254 688818 SGTC_48 0382-0018 55 µM 0.653810845954434 0.267392324914883 no 933 0.256616838985179 1362 762596 SGTC_1792 st045773 43.6 µM 0.652960024372533 0.267646978992767 no 934 0.256891025239478 1216 2919270 SGTC_503 tyrphostin 8 294 µM 0.64838498659819 0.269018397445499 no 935 0.258367989143576 1234 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_758 0868-0029 16 µM 0.647814746197415 0.269189580230263 no 936 0.25855238830586 1280 762687 SGTC_1169 aniline yellow 25.8 µM 0.647322358728238 0.269337435977589 no 937 0.25871166690924 1246 6051 A DNA damaging agent. SGTC_817 1391-0715 46 µM 0.646992292925265 0.269436572028099 no 938 0.2588184657636 1240 1353946 SGTC_694 1315-0438 43.2 µM 0.645463702582178 0.269895926159876 no 939 0.259313366565783 1237 6793154 SGTC_900 1112-0045 141 µM 0.645104247511486 0.270004002306524 no 940 0.259429815745423 1199 56211 YIL048W NEO1 SGTC_2927 9011802 47.9 µM 0.644760036670689 0.270107515316162 no 941 0.259541351711976 1259 43912568 SGTC_2896 9052656 71.43 µM 0.64439323127026 0.2702178449333 no 942 0.259660236327865 1250 6469436 SGTC_1607 st000305 50.6 µM 0.644043583538601 0.27032303475412 no 943 0.259773586166377 1299 5457690 SGTC_2446 5162541 200 µM 0.643771009307104 0.270405051583896 no 944 0.259861967796849 1241 1549321 SGTC_2084 5306078 60.6385 µM 0.643456537266607 0.270499690796821 no 945 0.259963953974466 1235 679340 SGTC_592 k241-0073 46.5 µM 0.638677166143886 0.271940058986627 no 946 0.261516485010391 1302 4230158 SGTC_2817 7995342 71.43 µM 0.638342995653998 0.272040911100478 no 947 0.261625214735178 1242 18879975 SGTC_2848 9016370 25.97 µM 0.637633832089583 0.272254997113599 no 948 0.261856033548195 1303 7894410 SGTC_1507 4075-3230 155 µM 0.635634979039491 0.272858871533199 no 949 0.262507182554732 1224 659771 SGTC_1612 st002233 45.4 µM 0.63528427108601 0.272964892540552 no 950 0.262621515050401 1290 1035021 SGTC_2549 cedrol 20.94 µM 0.633405467515584 0.273533213108152 no 951 0.26323444774111 1276 6708665 A sedative which affects the nervous system. SGTC_2625 euphol 100 µM 0.630968244379882 0.274271321920318 no 952 0.264030644085202 1301 6708538 A triterpene alcohol. SGTC_2508 celastrol 40.54 µM 0.629865650963687 0.274605563236074 no 953 0.264391243975768 1249 122724 Celastrol is a natural product and antioxidant. SGTC_2420 aureobasidin a 50 nM 0.624900338516735 0.276113238253097 no 954 0.266018235076115 1423 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1102 cgs 12066b 26.1 µM 0.621695416957489 0.277088538680611 no 955 0.267071082892092 1290 6438352 A 5-HT1B full agonist. SGTC_2462 5162487 171.77 µM 0.619623506657762 0.277719944636119 no 956 0.267752843501666 1279 2259986 SGTC_410 α-linolenic acid 100 µM 0.619065362123404 0.277890156903608 no 957 0.267936650382468 1338 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3137 9097352 49.47 µM 0.618600399872807 0.278031991085214 no 958 0.2680898191876 1395 44120435 SGTC_218 alverine citrate 93.75 µM 0.618471680304313 0.278071262524346 no 959 0.268132230036522 1330 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2512 diallyl trisulfide 49.23 µM 0.618180072754761 0.278160239954087 no 960 0.268228322117606 1300 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2930 9013230 14.89 µM 0.618159544505631 0.278166504206814 no 961 0.268235087348925 1308 2995857 SGTC_2026 5148700 152 µM 0.617295824457044 0.278430133125695 no 962 0.268519810241337 1295 79838 SGTC_655 k060-0012 42 µM 0.615391348778285 0.279011856464227 no 963 0.269148151660689 1279 5994525 SGTC_595 3909-8003 73.7 µM 0.61369698952248 0.279529895998592 no 964 0.269707789048711 1354 699517 SGTC_3010 9080089 71.4286 µM 0.613469556577003 0.279599467705671 no 965 0.269782953222027 1355 17027233 SGTC_1240 0356-0016 42.1 µM 0.612784260847747 0.279809150383369 no 966 0.270009499585252 1334 4305613 SGTC_263 alizarin 107.927 µM 0.612660272937001 0.279847095608435 no 967 0.2700504979116 1326 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2776 terbinafine 19.92 µM 0.611281404461954 0.280269252264217 no 968 0.270506649762175 1317 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1850 st056238 17 µM 0.610074088136795 0.280639139335799 no 969 0.270906365258992 1315 5393177 SGTC_550 4123-0385 25.7 µM 0.609933202785811 0.280682317946641 no 970 0.270953028451671 1306 5731123 SGTC_1353 1498-1206 8.11 µM 0.608478404586853 0.281128373025886 no 971 0.271435112286847 1357 6756808 SGTC_578 3460-0051 92 µM 0.60800678486776 0.281273049609995 no 972 0.271591486965671 1375 2876744 SGTC_3329 9141233 27.5565 µM 0.606491452545148 0.281738144187475 no 973 0.272094228258323 1357 4909101 YNL103W MET4 SGTC_477 mead ethanolamide 10 µM 0.606115552200465 0.281853575061152 no 974 0.272219012173409 1223 16061185 SGTC_525 k781-2675 26.7 µM 0.605925248148651 0.281912022011302 no 975 0.272282196367029 1366 3651118 YDL195W SEC31 SGTC_1740 st038286 13.222 µM 0.604468997260133 0.282359464868012 no 976 0.272765937618607 1366 716786 SGTC_1579 chlormadinone acetate 49.4 µM 0.60087607416318 0.283464873571531 no 977 0.273961265034389 1363 45114258 A steroidal progestin. SGTC_210 3551-0445 56.827 µM 0.600572463985233 0.283558378084995 no 978 0.274062391433402 1386 2865180 YOR207C RET1 SGTC_1518 st038567 90.8 µM 0.599942199878917 0.283752531194211 no 979 0.274272378506438 1317 77966 SGTC_1010 4112-3296 15.2 µM 0.592185933281981 0.286147049075197 no 980 0.276863043960516 1384 704384 SGTC_3244 9134489 49.47 µM 0.591888126652724 0.286239179089501 no 981 0.27696275255959 1297 16584271 SGTC_2831 7999036 19.48 µM 0.591769402346849 0.286275911789019 no 982 0.277002507529843 1460 2988270 SGTC_943 3253-1379 105 µM 0.589428726501864 0.287000561702568 no 983 0.277786855436166 1400 668464 SGTC_2020 4017018 200 µM 0.589179425154042 0.287077794083601 no 984 0.277870458838342 1358 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_944 3370-0224 231 µM 0.588919711153283 0.287158262720665 no 985 0.277957567192741 1336 4580514 SGTC_3155 9099265 49.47 µM 0.588128494760861 0.287403475501404 no 986 0.278223024131525 1334 25236499 SGTC_2158 5657123 3.6195 µM 0.588023289289796 0.287436088106568 no 987 0.278258330386549 1333 2858827 SGTC_1859 st055998 20 µM 0.587911136559049 0.287470856217521 no 988 0.278295970500964 1416 676301 SGTC_980 1473-0395 201 µM 0.586689824824394 0.287849599869658 no 989 0.278706021381651 1307 768876 SGTC_367 0335-0881 7.1 µM 0.585793524461385 0.288127703391859 no 990 0.279007137925191 1392 23828853 SGTC_1795 st049545 62.3 µM 0.58510828364081 0.288340404966498 no 991 0.279237454646947 1337 5291882 SGTC_98 0074-0023 107.663 µM 0.58421439807383 0.288617981960133 no 992 0.279538037901486 1315 3563821 SGTC_2027 5150920 200 µM 0.581173689092475 0.289563150047393 no 993 0.280561699236016 1365 786715 SGTC_393 acivicin 6.25 µM 0.575258438118281 0.291405987023114 no 994 0.282558262860162 1342 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1681 tripelennamine 100 µM 0.575013282409419 0.291482480765398 no 995 0.282641157001755 1349 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2749 bexarotene 57.39 µM 0.574050199170683 0.291783073638344 no 996 0.282966916028176 1355 82146 An retinoic acid receptor inhibitor. SGTC_2283 7944793 200 µM 0.573813353844296 0.291857018775528 no 997 0.283047055612634 1320 2970533 SGTC_316 k060-0003 58.6 µM 0.573251604366481 0.292032436664219 no 998 0.283237174136439 1390 6152314 SGTC_2953 9074162 66.49 µM 0.572878120340108 0.292149091931333 no 999 0.283363609982139 1434 16451992 SGTC_532 1548-0774 215 µM 0.571786676778935 0.292490121331175 no 1000 0.283733252257003 1491 5932993 SGTC_129 0088-0017 176.636 µM 0.57123465986285 0.292662673417966 no 1001 0.283920293272522 1341 182446 SGTC_2695 st077686 51.995 µM 0.569846222185248 0.293096886806309 no 1002 0.284391001127552 1337 2876092 SGTC_2382 9035899 200 µM 0.568452251126278 0.293533131021919 no 1003 0.284863959707212 1393 6462679 SGTC_2525 harmine 47.85 µM 0.567999256095154 0.293674960839085 no 1004 0.285017736532375 1423 5280953 A monoamine oxidase inhibitor SGTC_2152 5568786 200 µM 0.567833727269056 0.293726794756819 no 1005 0.285073937965146 1366 5399883 SGTC_2292 7671323 168.05 µM 0.56741235676794 0.293858762381312 no 1006 0.285217028279483 1372 937504 SGTC_1959 st077091 55.8 µM 0.567107765588844 0.293954173353243 no 1007 0.285320483612731 1381 821356 YKL052C ASK1 SGTC_1373 2887-0003 58.5 µM 0.566000312450178 0.29430119565959 no 1008 0.285696784057984 1380 776948 SGTC_2772 vinpocetine 57.06 µM 0.565787733338792 0.294367829320805 no 1009 0.285769043113204 1430 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2262 9014885 67.46 µM 0.563417654493305 0.295111210093237 no 1010 0.286575259122394 1352 6457424 SGTC_1631 benzylvanillin 81.9 µM 0.562061122288497 0.295537078234085 no 1011 0.287037187788919 1429 75506 SGTC_128 0906-2981 13.371 µM 0.561567690754002 0.295692055614348 no 1012 0.287205299358034 1428 6740226 SGTC_735 3076-0345 636 µM 0.561170077695371 0.295816965416252 no 1013 0.287340799578595 1483 2888990 SGTC_945 3381-0768 11.3 µM 0.560228423395841 0.29611288193987 no 1014 0.287661820994868 1389 1126236 YIL048W NEO1 SGTC_2105 5350118 200 µM 0.558388665096752 0.296691420817335 no 1015 0.288289505606056 1383 2133313 SGTC_768 0384-0033 77.3 µM 0.558080005196118 0.296788534115599 no 1016 0.288394876737476 1374 3965305 YMR134W ERG29 SGTC_256 clotrimazole 625 nM 0.557253724409296 0.297048577446627 no 1017 0.288677043974011 1381 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2751 anetholtrithion 17.25 µM 0.55536958719114 0.297641933902606 no 1018 0.289320945188938 1435 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1516 st013856 110 µM 0.554252296066546 0.297994048854536 no 1019 0.289703096348586 1386 5281404 A mutagen and neurotoxin. SGTC_928 2764-0428 58.7 µM 0.553779302749505 0.298143170154066 no 1020 0.2898649473175 1464 662578 SGTC_1022 4477-0945 21.3 µM 0.552333424363027 0.298599225001747 no 1021 0.29035996725101 1396 4648966 SGTC_527 4476-4215 268 µM 0.552064011094866 0.298684237621604 no 1022 0.290452248988936 1429 4418754 SGTC_2706 st078239 82.5 µM 0.55034168402407 0.29922797305502 no 1023 0.291042519363973 1395 15434492 SGTC_2869 9037858 32.47 µM 0.549128543986559 0.299611228473559 no 1024 0.291458618868714 1356 27187042 SGTC_2069 5228469 200 µM 0.549075264237964 0.299628065719009 no 1025 0.291476899851433 1356 2835210 SGTC_1892 st058411 7.36 µM 0.548908916029355 0.299680637149378 no 1026 0.291533979551734 1474 3934738 SGTC_924 2046-0044 21.3 µM 0.547249880090133 0.300205174804253 no 1027 0.292103535959815 1378 3623589 SGTC_1942 st076330 65.2 µM 0.545866338565909 0.300642926510237 no 1028 0.292578909236037 1437 24208414 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.543455203999508 0.301406495815311 no 1029 0.293408212832905 1393 16623 A steroid. SGTC_476 mead acid 10 µM 0.541019076062687 0.302178865462822 no 1030 0.294247217174246 1452 5312531 An omega 9 fatty acid. SGTC_641 4092-0595 30 µM 0.537726502007862 0.303224178950843 no 1031 0.295382939989738 1451 786260 SGTC_345 1362-0200 395 µM 0.53751306726802 0.303291995140146 no 1032 0.295456630576461 1408 1419823 SGTC_1999 st074831 12.5 µM 0.535040179112277 0.304078217853666 no 1033 0.296311037026463 1401 17112523 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.534922986167428 0.304115500365186 no 1034 0.29635155641129 1449 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_871 0574-0004 149 µM 0.534194332773227 0.304347352062213 no 1035 0.296603544831766 1437 9551173 SGTC_2483 5729050 27.16 µM 0.533054282067629 0.304710264898948 no 1036 0.296998002565736 1552 2865180 SGTC_1852 st056254 31.4 µM 0.531809807949396 0.305106638383954 no 1037 0.297428864544509 1462 442583 SGTC_2329 6138490 200 µM 0.53116756464759 0.305311286761118 no 1038 0.297651333718758 1459 720019 SGTC_1020 4335-0961 93.3 µM 0.530858220481806 0.30540987982283 no 1039 0.297758515746198 1369 669075 SGTC_1877 wortmannin 25 µM 0.528733597781248 0.306087413052219 no 1040 0.29849513341578 1443 312145 A covalent inhibitor of PI 3-kinase. SGTC_2307 7538926 6.34 µM 0.525767026286021 0.307034550631502 no 1041 0.299525043666857 1437 96582 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.52132914326781 0.308453839649559 no 1042 0.301068751239355 1476 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3236 9132701 49.47 µM 0.519271443245178 0.309112891512002 no 1043 0.301785732199045 1415 24282524 SGTC_2661 dactinomycin 12.96 µM 0.518985593682898 0.309204493718885 no 1044 0.30188539374663 1448 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1993 st073995 70.8 µM 0.517783672983332 0.309589786158864 no 1045 0.302304605532567 1477 3098394 SGTC_2358 9037157 4 µM 0.517772647109411 0.309593321626169 no 1046 0.302308452399529 1503 2388925 SGTC_580 1123-0028 41 µM 0.51745816406021 0.309694168627069 no 1047 0.302418183056133 1482 1677248 YPR107C YTH1 SGTC_2130 NSC 7 2.4545 µM 0.517390365531174 0.309715911830062 no 1048 0.302441841924556 1524 21448 SGTC_2009 4012297 12.05 µM 0.516147869968283 0.310114501941644 no 1049 0.302875568118714 1446 45595307 SGTC_888 0916-0002 6.97 µM 0.5157618016009 0.310238397385109 no 1050 0.303010392255309 1498 2802138 YIL048W NEO1 SGTC_3167 9103034 49.47 µM 0.515551775329399 0.310305807184322 no 1051 0.303083749636479 1467 5127859 SGTC_3328 9140624 29.0385 µM 0.515341957448216 0.310373156462725 no 1052 0.303157042163377 1558 4904392 SGTC_3047 9092122 49.47 µM 0.514461737338875 0.310655766903873 no 1053 0.303464602562322 1423 17173831 SGTC_1186 1319-0216 26 µM 0.511282727507366 0.311677374821933 no 1054 0.304576548933871 1576 4565136 SGTC_3171 9103192 49.47 µM 0.509752088110738 0.312169779818645 no 1055 0.305112577908182 1503 13018434 SGTC_1527 coumarin 137 µM 0.509347967118999 0.312299841151599 no 1056 0.305254170684331 1516 323 A hepatotoxic, DNA x-linker. SGTC_2274 7947094 46.08 µM 0.508970846761333 0.312421233765549 no 1057 0.30538632948028 1439 2971028 SGTC_1611 st001856 99.4 µM 0.50667233255819 0.313161550496172 no 1058 0.306192373305303 1420 647478 SGTC_814 3342-0569 96 µM 0.506085874993754 0.313350560435562 no 1059 0.306398182987585 1495 4346283 SGTC_2671 danthron 100 µM 0.505620479189046 0.313500588169682 no 1060 0.306561551094318 1450 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_265 mycophenolic acid 32.932 µM 0.504089444491676 0.313994359176818 no 1061 0.307099262064889 1532 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2207 7258803 200 µM 0.503603157173537 0.314151260516515 no 1062 0.307270136766844 1504 3666799 SGTC_2920 7982904 15.77 µM 0.501776617150108 0.314740896307905 no 1063 0.307912331487057 1437 6456808 SGTC_826 1683-5028 118 µM 0.50133487577451 0.314883568393441 no 1064 0.308067732190573 1499 722377 SGTC_1875 nocodazole 6 µM 0.501262741198967 0.314906868791481 no 1065 0.308093111765102 1498 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2536 dehydroabietamide 32.04 µM 0.500641123838186 0.315107689736166 no 1066 0.308311857442207 1604 3983547 SGTC_1237 0330-0133 46.1 µM 0.500135447066767 0.315271095004555 no 1067 0.308489854125015 1459 X1237 YHR072W ERG7 SGTC_840 0245-0196 390 µM 0.498156709324463 0.315910854955227 no 1068 0.309186796239032 1551 3827528 SGTC_2987 9018338 71.43 µM 0.496401149064664 0.316478919854053 no 1069 0.309805707265444 1493 5055682 SGTC_2415 st077333 57.7 µM 0.494127279510223 0.317215343378035 no 1070 0.310608146628399 1721 2766255 SGTC_3180 9109287 49.47 µM 0.492591509199691 0.317713133482806 no 1071 0.311150624346287 1489 18891271 SGTC_818 4072-2707 53.5 µM 0.492482569389024 0.317748456738565 no 1072 0.311189120588546 1434 882871 SGTC_2981 9013952 38.96 µM 0.492070981003211 0.317881927437969 no 1073 0.311334582901584 1382 2996344 SGTC_1897 st060201 15 µM 0.489961310482757 0.318566426777546 no 1074 0.312080638376953 1455 611878 SGTC_234 nsc-17383 10.7 µM 0.489874424981422 0.318594630769094 no 1075 0.312111380779228 1566 408974 SGTC_6 0844-0013 19.835 µM 0.489686094101274 0.318655768657051 no 1076 0.312178021747723 1555 1584900 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.489529916230463 0.31870647245238 no 1077 0.312233290020896 1516 77254 SGTC_1295 1013-0063 9.78 µM 0.489201723884664 0.318813032522367 no 1078 0.31234944459821 1589 6826038 SGTC_325 2810-4341 181 µM 0.489113883922856 0.318841555633269 no 1079 0.312380536280439 1598 774970 SGTC_2902 5787006 60.46 µM 0.48856663517084 0.319019280656183 no 1080 0.31257426958869 1473 591003 SGTC_1953 st076800 12.1 µM 0.482492439661359 0.320994728822044 no 1081 0.314728083924746 1449 297591 SGTC_2828 7998861 71.43 µM 0.481575508285524 0.321293375445131 no 1082 0.31505376405294 1591 2988188 SGTC_1320 1313-0481 95.3 µM 0.481223929184845 0.321407916220941 no 1083 0.31517867778327 1563 6813365 YLR208W SEC13 SGTC_2939 9044578 71.43 µM 0.480245104798014 0.321726896361967 no 1084 0.315526558914491 1463 2653634 SGTC_45 0kpi-0036 14.9 µM 0.479600814249628 0.321936930080069 no 1085 0.315755633629418 1548 2795021 SGTC_1403 3909-7815 62.9 µM 0.47900516718606 0.322131157018548 no 1086 0.31596747634536 1556 6615483 SGTC_2060 5238662 140 µM 0.478891545272321 0.32216821205571 no 1087 0.316007893006028 1493 790130 SGTC_957 1187-1561 14.1 µM 0.478600822483709 0.322263032303691 no 1088 0.316111316557482 1488 1538454 SGTC_2946 9065502 71.43 µM 0.4780522085859 0.322441996138707 no 1089 0.316306523109836 1416 16489101 SGTC_1519 esterone 74 µM 0.477423185997953 0.322647240809316 no 1090 0.316530403506839 1438 698 A steroid. SGTC_1965 Pectolinarigenin 58.4 µM 0.477110772384103 0.322749198782258 no 1091 0.316641622100189 1488 5320438 An anti-inflammatory. SGTC_2391 6285546 200 µM 0.475927827056311 0.323135380479148 no 1092 0.317062898330804 1486 846083 SGTC_3287 9117173 37.0625 µM 0.471908621544205 0.324448904050995 no 1093 0.318496006961583 1508 2789709 SGTC_406 estrone 100 µM 0.471435396724766 0.324603703706859 no 1094 0.31866492182114 1635 5870 A steroid. SGTC_1694 st024011 44.9 µM 0.470598790301576 0.324877445621272 no 1095 0.318963635831813 1559 2787533 SGTC_1231 0242-0792 125 µM 0.470387339655914 0.324946648337794 no 1096 0.319039153845574 1495 3707635 SGTC_2932 9016711 44.54 µM 0.470182732983582 0.325013616936829 no 1097 0.319112234736484 1640 7117328 SGTC_517 1365-0151 113 µM 0.469990266784046 0.325076617070424 no 1098 0.319180985741743 1546 768657 SGTC_832 4083-0019 164 µM 0.468980390660888 0.325407262661907 no 1099 0.319541826283693 1652 1990758 SGTC_400 oxethazaine 37.5 µM 0.464071045434818 0.327016595893528 no 1100 0.321298422794318 1517 4621 A local anesthetic. SGTC_145 3737-0113 38.366 µM 0.463751796039147 0.327121360985519 no 1101 0.321412791462541 1620 6849351 SGTC_3110 9122132 49.47 µM 0.463568094318425 0.327181650838765 no 1102 0.32147860888304 1606 918317 SGTC_64 000l-0018 272.079 µM 0.463431433969909 0.327226504908214 no 1103 0.321527575760047 1544 6811119 SGTC_3247 9135149 49.47 µM 0.463406748784528 0.327234607239234 no 1104 0.321536421058957 1530 8934436 YOR116C RPO31 SGTC_1260 0700-1617 7.75 µM 0.463343956183254 0.327255217799394 no 1105 0.321558921622617 1553 2853078 SGTC_805 3852-0218 479 µM 0.463037974385873 0.327355658445163 no 1106 0.321668573888909 1491 6615355 SGTC_233 rapamycin 362 pM 0.462966415855128 0.327379149832629 no 1107 0.321694219993106 1560 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1352 1496-0991 99 µM 0.458747165949973 0.328765459930719 no 1108 0.323207869696099 1539 3000039 SGTC_2045 5106652 78.05 µM 0.458053433367401 0.328993624565443 no 1109 0.323457026539698 1601 673349 SGTC_2649 anisomycin 9.56 µM 0.457265038464743 0.329253000457571 no 1110 0.32374027786195 1524 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1123 mangostin 811.285 nM 0.457201321382316 0.329273966482092 no 1111 0.323763174339338 1515 5281650 An antioxidant. SGTC_73 0327-0325 16.231 µM 0.456146500093559 0.32962113204977 no 1112 0.32414231699588 1635 53298 SGTC_2659 sanguinarine 24.21 µM 0.455469567435055 0.329844003307068 no 1113 0.324385728335372 1526 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1133 3473-0247 50 µM 0.454420060070231 0.330189659368904 no 1114 0.324763258395621 1462 711311 SGTC_195 4234-0266 16.654 µM 0.453663339294222 0.330438975914228 no 1115 0.325035578667761 1531 2303354 SGTC_429 1112-0049 25.5 µM 0.452047689115688 0.330971535475705 no 1116 0.325617313694726 1495 2836170 SGTC_2847 9005661 71.43 µM 0.451105178709738 0.331282369095236 no 1117 0.325956872709217 1521 2991449 SGTC_887 0885-0007 9.62 µM 0.451104094883613 0.331282726600805 no 1118 0.325957263263332 1627 5719458 SGTC_2206 7254556 146.969 µM 0.448770442894533 0.33205284973595 no 1119 0.326798631323123 1605 4398905 SGTC_1667 st014849 34.6 µM 0.446540693606613 0.332789347568897 no 1120 0.32760336225743 1575 5348460 SGTC_2879 9041815 71.43 µM 0.445821013383523 0.333027199679057 no 1121 0.327863270784786 1533 4942971 SGTC_2184 6075246 200 µM 0.445491572426989 0.33313610133045 no 1122 0.327982274396628 1596 2267320 SGTC_2729 fluphenazine 10.66 µM 0.444807592600043 0.333362246052715 no 1123 0.328229403478842 1488 3372 An atypical antipsychotic. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.444544182164586 0.333449353789836 no 1124 0.328324596492092 1639 688761 SGTC_160 3453-0671 289.699 µM 0.443865598010323 0.333673797538129 no 1125 0.328569879078714 1488 5322268 SGTC_916 4466-0038 42 nM 0.442563873071272 0.334104513563363 no 1126 0.329040610311106 1631 5722064 YGL116W CDC20 SGTC_1269 0831-0796 3.05 µM 0.442419467063938 0.334152308243768 no 1127 0.329092847300587 1637 927758 SGTC_432 NS 1619 61.3 µM 0.440936829643965 0.334643178599406 no 1128 0.329629364929711 1587 4552 A K+/calcium channel activator. SGTC_1281 0884-0031 11.8 µM 0.440698410653298 0.334722140570943 no 1129 0.329715673678431 1539 1548255 SGTC_236 1509-0011 5.31 µM 0.440012925283508 0.334949207138358 no 1130 0.32996387297788 1594 3107280 SGTC_1557 sumaresinolic acid 42.3 µM 0.437544407210227 0.335767401542709 no 1131 0.330858289148454 1507 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1024 4507-0395 26 µM 0.43710236022354 0.335914001111372 no 1132 0.331018557846647 1600 4201836 SGTC_2239 6685329 187.64 µM 0.435314832815665 0.336507067512602 no 1133 0.331666959925953 1551 805680 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.434894592680097 0.336646554053232 no 1134 0.331819469855322 1496 5711223 A potent inhibitor of glutathione S-transferases. SGTC_534 k292-0788 63.4 µM 0.433435093766289 0.337131166933179 no 1135 0.332349355005505 1708 4146317 SGTC_3024 9090631 49.47 µM 0.430953527255254 0.337955768160855 no 1136 0.333251080906336 1652 25236383 SGTC_38 0929-0051 58.268 µM 0.429755472939178 0.338354149151551 no 1137 0.333686763088172 1724 1379719 SGTC_1980 st071811 45.7 µM 0.429653966078783 0.33838791087296 no 1138 0.333723687200186 1633 4974850 SGTC_2963 9082507 9 µM 0.428837694342409 0.338659454404185 no 1139 0.334020672535804 1635 16459611 SGTC_2309 7664088 163.95 µM 0.428285127016689 0.3388433208191 no 1140 0.334221772938154 1705 704922 SGTC_124 0136-0217 7.121 µM 0.428145996574317 0.338889622436449 no 1141 0.334272415335105 1671 3976905 SGTC_3354 9151612 71.43 µM 0.427881386604104 0.338977689461068 no 1142 0.334368739626646 1676 27261949 SGTC_3014 9081533 49.47 µM 0.427814735246538 0.338999873636339 no 1143 0.334393004018019 1686 21367265 SGTC_2836 9010338 19.48 µM 0.423955104612106 0.340285459537893 no 1144 0.33579927775225 1458 2994051 SGTC_707 0865-0008 204 µM 0.422140079234905 0.340890661130814 no 1145 0.336461387583304 1663 723043 SGTC_2951 9072950 58.06 µM 0.422138864679875 0.340891066249068 no 1146 0.336461830815447 1607 16488155 SGTC_1982 st072467 71.9 µM 0.421376308417112 0.341145455243083 no 1147 0.336740158184934 1569 3163533 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.419832758825707 0.341660604792036 no 1148 0.337303815951723 1558 688664 SGTC_2063 5246145 200 µM 0.417742892226971 0.342358554111824 no 1149 0.338067554265984 1645 711240 SGTC_2601 securinine 100 µM 0.417134203861476 0.342561938180326 no 1150 0.338290123986905 1560 442872 A GABA receptor antagonist. SGTC_2918 7977171 22.06 µM 0.414115114160598 0.343571395433328 no 1151 0.339394902182026 1583 2236483 SGTC_843 0310-0051 143 µM 0.412879106529609 0.343984987230296 no 1152 0.339847594776543 1628 2065037 SGTC_2700 st077718 96.8 µM 0.411172156381919 0.344556472348796 no 1153 0.340473151695468 1584 904970 SGTC_492 tmb-8 126 µM 0.41098823234924 0.344618071129872 no 1154 0.340540581748485 1662 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_19 0279-0214 38.434 µM 0.410635187546814 0.344736322412178 no 1155 0.340670028977469 1642 3566274 YBR002C RER2 SGTC_2146 5545642 200 µM 0.409268278274723 0.345194307503713 no 1156 0.341171396121342 1611 825326 SGTC_2745 rifampicin 24.3 µM 0.409199513195118 0.345217353348885 no 1157 0.341196625807621 1726 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_303 1348-1668 34.2 µM 0.406344649627419 0.346174634523281 no 1158 0.342244691432712 1639 5380509 SGTC_569 4130-2812 160 µM 0.406180452241789 0.346229722492314 no 1159 0.342305007957598 1653 743552 SGTC_649 1123-0311 367 µM 0.405847129378294 0.346341561803064 no 1160 0.342427463671331 1664 693629 YIL048W NEO1 SGTC_1789 tunicamycin 25 nM 0.405430150212408 0.346481489049766 no 1161 0.342580676250951 1596 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_575 k072-0246 11.9 µM 0.404813040689929 0.346688613227783 no 1162 0.342807471180747 1635 6796779 SGTC_2973 9094665 17.96 µM 0.404538417963267 0.346780801244763 no 1163 0.342908416451265 1732 25237061 YIL048W NEO1 SGTC_1876 myriocin 605 nM 0.404447452274067 0.346811339488943 no 1164 0.342941855909697 1719 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1036 k216-0215 33.5 µM 0.404441458343022 0.346813351756545 no 1165 0.342944059352997 1594 622330 SGTC_1712 st032288 53.4 µM 0.403750939071148 0.347045200076612 no 1166 0.343197938527714 1593 2883011 SGTC_2779 methotrexate 400 µM 0.401495074826841 0.347803026405656 no 1167 0.344027831780716 1623 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2200 6600604 21.907 µM 0.399198035065168 0.348575310356896 no 1168 0.344873645472568 1604 2904777 SGTC_1969 st069479 40.1 µM 0.398516519433595 0.348804562552687 no 1169 0.345124741909091 1701 3895485 SGTC_262 fenpropimorph 62.5 µM 0.397843489029017 0.349031014626102 no 1170 0.34537277900105 1588 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1904 st060225 78 µM 0.397608442328154 0.349110112601387 no 1171 0.345459418230976 1606 66595 SGTC_207 4185-0010 4.486 µM 0.396029011896997 0.349641792812481 no 1172 0.34604181293446 1652 3761753 SGTC_1223 0764-0573 147 µM 0.395406403463996 0.349851461266711 no 1173 0.346271492008393 1615 1609797 SGTC_1000 4048-0884 8.67 µM 0.395185650399081 0.349925812657395 no 1174 0.346352940980424 1666 13040088 SGTC_2866 9034245 58.44 µM 0.394116121023355 0.350286120105405 no 1175 0.346747654707548 1742 6462273 SGTC_497 capsazepine 133 µM 0.392028358257605 0.350989842299323 no 1176 0.347518630322361 1554 2733484 A calcium channel blocker. SGTC_3321 9137793 26.8275 µM 0.391678770926175 0.351107727749889 no 1177 0.347647788813051 1632 4904192 SGTC_1023 4482-3888 16 µM 0.39148861029926 0.35117185843494 no 1178 0.347718052961684 1729 3303168 SGTC_1765 st044815 90.4 µM 0.390954907782213 0.351351869476 no 1179 0.347915283408116 1562 645695 SGTC_1652 st011932 78 µM 0.389457348407693 0.351857155085311 no 1180 0.348468928002598 1719 1551076 SGTC_2046 4110841 106 µM 0.388790346835819 0.352082289768383 no 1181 0.348715621131033 1691 44119630 YMR134W ERG29 SGTC_3142 9086498 49.47 µM 0.386857598234829 0.352734947763942 no 1182 0.349430816702685 1749 25236367 SGTC_612 0302-0167 22.4 µM 0.386762124659358 0.352767198904335 no 1183 0.349466159691787 1738 235821 SGTC_2237 6667747 47.222 µM 0.385549166565837 0.353177030308994 no 1184 0.349915293422157 1619 729940 YDL015C TSC13 SGTC_2013 4024628 200 µM 0.385263406634119 0.353273607008116 no 1185 0.350021135115606 1685 5230760 SGTC_389 tpck 16.7 µM 0.382626529778565 0.354165222842867 no 1186 0.350998348305621 1649 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1021 4476-0760 85.3 µM 0.381092665348044 0.354684241876567 no 1187 0.351567244856246 1601 746768 SGTC_3234 9132280 49.47 µM 0.380373590080476 0.354927650849422 no 1188 0.351834058013276 1658 17612295 SGTC_2119 5528445 120.635 µM 0.378869850615318 0.355436862161282 no 1189 0.352392256897616 1737 791935 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.37747318595865 0.355910046018226 no 1190 0.352910993805611 1687 2724278 An inhibitor of dopamine biosynthesis. SGTC_2100 5377183 190 µM 0.377410265606085 0.355931368390145 no 1191 0.35293436957571 1767 2844202 SGTC_3040 9091894 49.47 µM 0.376716747323095 0.3561664168599 no 1192 0.353192057848245 1715 25236966 SGTC_2073 5212005 126 µM 0.375626866134235 0.356535911792926 no 1193 0.353597157373567 1746 691789 SGTC_2724 maprotiline 69.64 µM 0.374245274891279 0.357004496743657 no 1194 0.354110921395344 1720 4011 A tricyclic antidepressant. SGTC_2142 5622915 118.518 µM 0.373149760824306 0.35737620827539 no 1195 0.354518492540176 1650 5322196 SGTC_3219 9131112 49.47 µM 0.372894883535415 0.357462708402188 no 1196 0.354613340088426 1673 17612988 YMR079W SEC14 SGTC_608 k048-0125 159 µM 0.370632099576781 0.358230971545416 no 1197 0.355455785115547 1764 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_319 1348-1596 45.5 µM 0.3664724192767 0.359644767672274 no 1198 0.357006294760653 1792 5380505 SGTC_421 streptovitacin 30 mM 0.362976886131395 0.360834320905036 no 1199 0.358311075353384 1675 91467 include heat shock SGTC_778 3456-2434 196 µM 0.357834356609187 0.362586805016098 no 1200 0.3602336389181 1839 5539063 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.355601340003908 0.363348677923636 no 1201 0.361069569991784 1669 115019 SGTC_1467 k284-1082 293 µM 0.355581515897659 0.363355444048073 no 1202 0.361076994136731 1805 3334705 SGTC_2600 tangeritin 87.95 µM 0.352350100119183 0.364458920314665 no 1203 0.362287859829435 1609 68077 A bioactive flavone. SGTC_2380 9035439 200 µM 0.351579223998127 0.364722328479341 no 1204 0.36257692424977 1778 6462575 SGTC_1051 3253-3903 78 µM 0.350352016617492 0.365141796652596 no 1205 0.363037266126286 1663 5509239 SGTC_1742 st038235 28.8875 µM 0.350212177079641 0.365189605050573 no 1206 0.363089734380206 1699 564103 YBR002C RER2 SGTC_1706 st031321 9.9705 µM 0.349824446053234 0.365322173648165 no 1207 0.363235225771777 1788 6103185 SGTC_837 0091-0265 12.5 µM 0.349760680325024 0.365343977244575 no 1208 0.3632591549825 1674 759367 SGTC_1699 st031318 29.054 µM 0.349412883395916 0.365462908094499 no 1209 0.363389681287293 1760 5340658 SGTC_733 4069-0007 56.1 µM 0.348127975922201 0.365902400550686 no 1210 0.363872037557064 1745 5717425 YNL287W SEC21 SGTC_2371 9071574 200 µM 0.348022850313001 0.36593836573321 no 1211 0.363911511434921 1778 45596039 SGTC_56 0957-0365 83.25 µM 0.343015456088407 0.367652836135224 no 1212 0.365793416260697 1746 6752360 SGTC_2409 alverine citrate 63.97 µM 0.342641371018067 0.367781024708449 no 1213 0.365934137236312 1823 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1096 rimcazole 32.2 µM 0.342019222069696 0.367994250501738 no 1214 0.366168213264061 1719 18528119 A dopamine reuptake inhibitor. SGTC_1774 st048371 48.465 µM 0.340855215834057 0.368393293363589 no 1215 0.366606290273271 1667 4242727 SGTC_1745 st081495 74 µM 0.340655512465114 0.368461769653656 no 1216 0.366681466681887 1755 13842402 YBL026W LSM2 SGTC_2681 menadione 3.18 µM 0.340215704183395 0.36861259024871 no 1217 0.366847046301855 1733 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1947 st076332 61.6 µM 0.340127542543705 0.368642825382849 no 1218 0.366880240497946 1821 24208416 SGTC_786 4544-0069 423 µM 0.338901940570523 0.369063231119928 no 1219 0.367341801252221 1784 748821 YLR208W SEC13 SGTC_940 3232-1287 54.8 µM 0.338778692326455 0.369105516385801 no 1220 0.367388227066749 1829 1585493 YIL048W NEO1 SGTC_2212 7123476 200 µM 0.337379908127125 0.369585536445276 no 1221 0.367915264352621 1777 1085715 SGTC_910 3454-3003 490 µM 0.337224835273248 0.369638765251603 no 1222 0.367973708412329 1806 820824 SGTC_2216 7189485 200 µM 0.337167765727676 0.36965835502019 no 1223 0.367995217626642 1796 731273 SGTC_3297 9117502 71.43 µM 0.336779422775023 0.369791667123385 no 1224 0.368141593049008 1747 7453720 SGTC_732 3970-1727 52.7 µM 0.336214034155135 0.369985784230302 no 1225 0.368354735291587 1860 1275699 SGTC_435 c-PAF 6.7 µM 0.335996150972603 0.370060599769402 no 1226 0.368436884499924 1812 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.33576375564281 0.37014040382994 no 1227 0.36852451189888 1823 94937 An inhibitor of serotonin biosynthesis. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.334020101362801 0.370739349116821 no 1228 0.36918219512972 1670 688669 SGTC_1758 st042942 75.2445 µM 0.332585846152411 0.371232250794301 no 1229 0.369723464426405 1796 669317 SGTC_880 0833-0487 87.2 µM 0.331751425611075 0.371519108247864 no 1230 0.370038482798467 1685 76075 SGTC_2374 9071832 200 µM 0.331392573748232 0.371642496451642 no 1231 0.370173986794586 1742 17381698 SGTC_2670 beta-carotene 100 µM 0.331352635140967 0.371656229822637 no 1232 0.37018906878014 1775 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_200 k038-0079 37.545 µM 0.328234217128827 0.372729038417309 no 1233 0.371367289080051 1765 3436683 SGTC_122 0236-0016 402.397 µM 0.326595219595455 0.373293288474288 no 1234 0.371987029827769 1748 6808838 SGTC_1101 ebselen 5.29 µM 0.326071058636363 0.373473796352511 no 1235 0.372185296629812 1873 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_752 1896-0090 130 µM 0.326054151838675 0.373479619091721 no 1236 0.37219169228464 1725 772567 SGTC_952 1185-0122 232 µM 0.326033009048048 0.373486900757089 no 1237 0.372199690418422 1698 678600 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.324676093655133 0.373954322455588 no 1238 0.372713114880967 1802 279621 SGTC_3011 9081274 71.4286 µM 0.324236924695697 0.374105644370364 no 1239 0.372879334456569 1731 6625322 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.323362939299777 0.374406846178645 no 1240 0.373210196634028 1772 165521 SGTC_1215 3852-0577 11.2 µM 0.323078978821038 0.374504724059759 no 1241 0.373317714888125 1843 2884876 SGTC_2051 5263410 176 µM 0.322600243690167 0.374669756810205 no 1242 0.373499004575161 1806 227584 SGTC_2172 5754775 163.918 µM 0.321627517964592 0.375005151962188 no 1243 0.373867447167643 1690 2263357 SGTC_1063 disulfiram 1.84 µM 0.31909677021299 0.37587819441718 no 1244 0.374826566371849 1762 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_194 1486-1323 56.904 µM 0.318861888961875 0.375959254675984 no 1245 0.374915622571786 1720 5178754 SGTC_710 3448-4187 58 µM 0.318847567326958 0.375964197416286 no 1246 0.374921052894822 1743 3946412 SGTC_2605 digitonin 300 nM 0.316312726288481 0.376839351800367 no 1247 0.375882576253367 1902 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_31 0508-1974 57.237 µM 0.316243938098282 0.376863109781883 no 1248 0.375908679966009 1825 6810525 SGTC_2287 7945887 168.79 µM 0.315851817060147 0.37699854897169 no 1249 0.376057492729289 1880 1245853 SGTC_1394 3474-0001 65.7 µM 0.315781496311443 0.37702283946394 no 1250 0.37608418191054 1722 5017666 YIL048W NEO1 SGTC_642 0335-0876 158 µM 0.315665933174823 0.377062758831419 no 1251 0.376128043446074 1750 6812350 SGTC_39 0986-0283 58.349 µM 0.312612781757803 0.378117894044536 no 1252 0.37728743304341 1890 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_289 k017-0060 526 µM 0.312112600958093 0.37829083790464 no 1253 0.377477475188608 1751 5512909 SGTC_1926 methyl fluorone black 53.6 µM 0.311604976319481 0.378466380499936 no 1254 0.377670375933059 1772 72721 Reacts with homocysteine. SGTC_2177 5811945 192 µM 0.311387641994781 0.3785415449469 no 1255 0.377752973756077 1850 5343475 SGTC_1729 st035615 45.989 µM 0.310823386350195 0.378736712574132 no 1256 0.377967444975393 1732 17385451 SGTC_2864 9034755 47.6 µM 0.310775655704085 0.378753223313476 no 1257 0.377985588921609 1900 4930451 SGTC_1801 st050089 28.441 µM 0.310721175355007 0.378772069145748 no 1258 0.378006298974869 1757 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1872 amphotericin b 148 nM 0.308407323104592 0.379572742048831 no 1259 0.378886205172607 1856 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_727 3032-0951 202 µM 0.307439065729251 0.379907946132955 no 1260 0.379254598436761 1790 3652836 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.304214062629236 0.381025069745516 no 1261 0.380482405916259 1869 23847180 SGTC_2799 7812892 81.82 µM 0.303941926716702 0.381119381682536 no 1262 0.380586067477156 1870 20205235 SGTC_214 4373-3496 70 µM 0.303252059673414 0.381358494940539 no 1263 0.380848888891809 1859 3779166 SGTC_3012 9080433 71.4286 µM 0.302221680820979 0.381715716551367 no 1264 0.38124153882191 1914 17688859 SGTC_3327 9140648 26.9345 µM 0.30018808066717 0.382421039940388 no 1265 0.382016848160351 1889 8029710 SGTC_189 3970-0742 2.116 µM 0.298178782697572 0.38311831782165 no 1266 0.382783357299854 1897 2891807 SGTC_683 panaxydol 45 µM 0.29678403492936 0.383602553955376 no 1267 0.383315697450112 1880 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3269 9137823 49.47 µM 0.296616633559468 0.383660685513134 no 1268 0.383379605176187 1746 17682936 SGTC_3220 9131269 49.47 µM 0.295236610968834 0.384140009821938 no 1269 0.383906568135191 1798 17722206 SGTC_674 0498-0004 451 µM 0.294365893499609 0.384442528041716 no 1270 0.384239162990272 1748 4231473 SGTC_2829 7992743 58.44 µM 0.293779787469537 0.384646201775473 no 1271 0.384463090581884 1980 16462845 SGTC_415 dibenzyl ketone 100 µM 0.29323072333354 0.384837032221052 no 1272 0.384672900935743 1910 7593 SGTC_3080 9117754 49.47 µM 0.291204639892531 0.385541450457235 no 1273 0.38544740707975 1903 9550191 SGTC_872 0588-0139 234 µM 0.289453313864729 0.386150646912655 no 1274 0.386117250780374 1775 2047100 SGTC_2740 felodipine 17.08 µM 0.287863636180381 0.386703857382366 no 1275 0.386725561664032 1931 3333 L-type calcium channel blocker SGTC_1180 1193-0155 285 µM 0.287135132870294 0.386957454764425 no 1276 0.387004426071175 1782 2921347 SGTC_2160 5660466 132.927 µM 0.287075948417935 0.386978059430656 no 1277 0.387027083902573 1928 2859134 SGTC_1811 st050069 61.5 µM 0.285407425305608 0.387559075312031 no 1278 0.387666009721873 1946 3877702 SGTC_3277 9138724 49.47 µM 0.284311606679296 0.387940800222923 no 1279 0.388085796082113 1837 15943418 SGTC_584 0986-0246 15.4 µM 0.283905099817244 0.388082433148672 no 1280 0.388241554077631 1891 53315 YDR232W HEM1 SGTC_802 4112-3352 742 µM 0.283286493839415 0.388297993062834 no 1281 0.388478614886997 1914 704594 SGTC_1950 st077106 7.18 µM 0.279073774295928 0.389766872479149 no 1282 0.390094104478508 1769 13831864 SGTC_1531 st059297 52.4 µM 0.278252861327939 0.390053290256745 no 1283 0.390409129451512 1847 7566702 SGTC_1454 4239-0054 42.6 µM 0.277168372227511 0.390431761654832 no 1284 0.390825411948101 1932 1340767 SGTC_2990 9074105 71.4286 µM 0.277034960381463 0.390478327687918 no 1285 0.390876630905739 1832 6502001 SGTC_547 1120-0019 610 nM 0.276359923795194 0.390713966339661 no 1286 0.391135817334081 1809 3676939 SGTC_3172 9105863 49.47 µM 0.274097408627223 0.391504046937178 no 1287 0.392004882611182 1868 2348785 SGTC_2263 7948595 193.29 µM 0.270819992751826 0.392649328875453 no 1288 0.393264741157313 1788 2971371 SGTC_2255 7941087 197.44 µM 0.269788749996014 0.393009886040458 no 1289 0.393661389107566 1955 935561 SGTC_983 1491-0821 12.2 µM 0.268496525887938 0.393461820636148 no 1290 0.394158574336176 1925 46495113 SGTC_2621 lithochol-11-enic acid 100 µM 0.267699035741188 0.393740801672754 no 1291 0.394465496050102 1975 6708711 SGTC_1825 st052143 62.6 µM 0.267692338384247 0.393743144798806 no 1292 0.394468073869736 1918 674173 SGTC_2581 avocatin a 64 µM 0.267640394008562 0.393761318101476 no 1293 0.39448806747074 1823 6710728 A skin care supplement. SGTC_3063 1327-0034 4 µM 0.265742149644631 0.394425597886887 no 1294 0.395218899703092 1908 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2094 5332512 191.667 µM 0.26436544677546 0.394907559479655 no 1295 0.395749167061701 1921 755774 SGTC_1405 3909-7894 12 µM 0.264300288907664 0.394930374196602 no 1296 0.395774268837553 1938 7104060 SGTC_1988 st071872 53.4 µM 0.262423854206498 0.395587553152625 no 1297 0.396497341963663 1972 16414116 SGTC_368 fentichlor 4.58 µM 0.261202803543141 0.396015358255037 no 1298 0.396968058117195 1803 7329 A pesticide. SGTC_2402 5553605 200 µM 0.260829340990542 0.396146228960297 no 1299 0.397112058290799 1900 6758546 SGTC_2728 chlorpromazine 9.18 µM 0.259119800110922 0.396745444448077 no 1300 0.397771404061299 1883 2726 A thorazine and dopamine antagonist. SGTC_2040 5100729 123 µM 0.258181505393623 0.397074432262757 no 1301 0.398133415369581 1881 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3189 9110682 49.47 µM 0.257449550171572 0.397331123556189 no 1302 0.398415878029 1832 17122418 SGTC_3166 9102297 49.47 µM 0.257125369989749 0.397444825369914 no 1303 0.39854099668338 1804 25237072 SGTC_1058 3448-5425 97.3 µM 0.256830700145955 0.397548184392812 no 1304 0.398654734752353 1947 7279705 SGTC_1089 terbinafine 2.25 µM 0.256003634204125 0.39783832621346 no 1305 0.398974015558744 1967 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_711 k292-0785 179 µM 0.255070494980561 0.398165747294906 no 1306 0.399334326090666 1841 4146315 SGTC_2062 5245942 200 µM 0.25284875964251 0.398945600885658 no 1307 0.400192543434202 1930 1376160 SGTC_2684 capsaicin 100 µM 0.251998560894554 0.399244136953663 no 1308 0.400521088077697 1885 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1328 1441-0025 69.2 µM 0.25194268791601 0.399263758078225 no 1309 0.400542681694292 1761 4562601 SGTC_3313 9133968 57.047 µM 0.251461887715095 0.39943261301011 no 1310 0.400728512430317 1878 1494643 SGTC_2528 xanthyletin 44.79 µM 0.251399580774686 0.399454496313321 no 1311 0.400752595897166 1823 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1590 st077108 57.8 µM 0.251158497809491 0.399539171904365 no 1312 0.400845785113917 1975 5489485 SGTC_1512 0259-0544 12.2 µM 0.251109000707582 0.399556557360649 no 1313 0.400864918628877 1888 18476 SGTC_513 4245-1575 41.7 µM 0.250339918719317 0.399826716750567 no 1314 0.401162244173068 1940 719745 SGTC_2431 5490079 200 µM 0.250335277184621 0.399828347352079 no 1315 0.401164038754977 1827 5722345 SGTC_930 2810-3379 265 µM 0.250115901678973 0.399905417394636 no 1316 0.401248859482501 1995 1015764 SGTC_1364 1653-0028 37.6 µM 0.249885163412428 0.399986483560015 no 1317 0.401338078601437 1863 5718652 SGTC_173 1273-0061 2.693 µM 0.247867105425958 0.400695678996711 no 1318 0.40211861593961 1791 2847414 YPL266W DIM1 SGTC_652 0437-0092 114 µM 0.24765989170709 0.400768517594032 no 1319 0.402198783488722 1829 3091274 SGTC_775 4577-0580 57.3 µM 0.246921914492058 0.401027955188835 no 1320 0.402484328021972 1923 2006902 SGTC_1957 st077035 62.4 µM 0.245423821565465 0.401554747352831 no 1321 0.403064142991392 1958 705593 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.244343801514502 0.401934638672856 no 1322 0.403482281302739 1899 7104 SGTC_2470 5664817 21.68 µM 0.242281281984266 0.402660376159652 no 1323 0.404281108294152 1887 2859561 SGTC_1105 epirubicin 18.1 µM 0.242059740565252 0.402738349804709 no 1324 0.404366936505145 1834 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1290 0986-0249 10.2 µM 0.240556341126998 0.40326758783449 no 1325 0.404949495644985 1981 53329 SGTC_84 0443-0269 128.823 µM 0.23973783683504 0.403555798472453 no 1326 0.405266750296604 1974 6150058 SGTC_1484 3473-2379 286 µM 0.239315290177172 0.403704605548359 no 1327 0.405430554993567 1999 671917 SGTC_1757 st041620 31.8375 µM 0.23916231136355 0.403758483107798 no 1328 0.405489862940105 1848 5289815 SGTC_2570 licareol 100 µM 0.237684593753249 0.40427901387298 no 1329 0.406062866844605 1842 443158 SGTC_914 3820-6779 408 µM 0.237533318580522 0.404332310617218 no 1330 0.406121537105643 1868 2893481 SGTC_2943 9068529 45.32 µM 0.237315935849631 0.404408901255733 no 1331 0.406205850081249 1954 3270634 SGTC_480 am 92016 50 µM 0.237119933339703 0.404477962124067 no 1332 0.406281874360716 1846 2129 K+ channel blocker. SGTC_883 0850-0245 24.6 µM 0.236660459012925 0.40463986812181 no 1333 0.406460106355671 1961 6823229 YPR165W RHO1 SGTC_1488 4013-0813 75.9 µM 0.235986734424044 0.40487729948266 no 1334 0.406721481950449 1868 2910057 SGTC_1128 3448-9350 235 µM 0.235651835227122 0.404995336373418 no 1335 0.406851423622946 1825 619386 SGTC_1152 3909-8331 15.9 µM 0.235328628995926 0.405109260216799 no 1336 0.406976838122021 1874 16001939 SGTC_2725 haloperidol 53.21 µM 0.234904724411771 0.405258690438883 no 1337 0.407141341306151 1958 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.234316231554331 0.405466162417623 no 1338 0.407369742842585 2024 756377 SGTC_2354 9060492 162 µM 0.233637209594416 0.405705583254657 no 1339 0.40763331900413 1986 6471895 SGTC_2168 5727979 200 µM 0.233343089712364 0.405809299881523 no 1340 0.407747500595144 1925 695210 SGTC_1414 3917-0015 5.4 µM 0.231628097161645 0.406414195769268 no 1341 0.408413441270998 1970 6618702 SGTC_17 0960-0276 49.807 µM 0.229799309976191 0.407059474338595 no 1342 0.409123860468121 1939 6821114 SGTC_2692 st077426 47.7 µM 0.228542427571151 0.407503105547195 no 1343 0.409612288146916 1996 25238571 SGTC_2133 5320837 200 µM 0.227947020587004 0.407713302794534 no 1344 0.409843713831355 1972 2841355 SGTC_3026 9090633 49.47 µM 0.227866501402101 0.407741730620535 no 1345 0.409875012832931 1872 25236842 SGTC_2561 acetosyringone 100 µM 0.226303454559773 0.408293670619616 no 1346 0.410482705866885 2043 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1340 1486-1359 257 µM 0.224868162042615 0.408800658583258 no 1347 0.411040919005896 1922 4309068 SGTC_987 1497-1013 404 µM 0.223051699330841 0.409442505916973 no 1348 0.41174763482709 1958 1676435 SGTC_1864 st057645 30.4 µM 0.221260000944056 0.41007584066573 no 1349 0.412444996375568 2046 688666 SGTC_1363 1636-0063 10.4 µM 0.220849300186409 0.410221049479554 no 1350 0.412604887601574 1914 6072185 SGTC_1423 4048-0112 5.59 µM 0.217813893981754 0.411294638893442 no 1351 0.413787059315237 2011 X1423 SGTC_598 3937-0236 20.2 µM 0.217709996151413 0.411331398209814 no 1352 0.413827537344911 1974 1379313 SGTC_2881 9058953 51.95 µM 0.217178885677047 0.411519318598836 no 1353 0.41403446939158 1969 17122249 SGTC_2775 cyproheptadine 69.59 µM 0.216842830164853 0.411638234071597 no 1354 0.414165416169766 2052 2913 A selective serotonin reuptake inhibitor. SGTC_3241 9133421 49.47 µM 0.216749048972102 0.411671420617949 no 1355 0.414201960482032 2027 17018221 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.215284178113369 0.412189879399814 no 1356 0.414772882231712 1891 688667 SGTC_560 2332-1943 155 µM 0.213893801939019 0.412682114242046 no 1357 0.415314936862503 1931 21177716 SGTC_3068 9116768 49.47 µM 0.213519122515237 0.412814785514294 no 1358 0.415461037696283 1924 41904888 SGTC_1277 0873-0036 22 µM 0.213287102540358 0.412896947102544 no 1359 0.415551516398376 1993 5965735 SGTC_2076 5212012 200 µM 0.210673829528349 0.413822607114184 no 1360 0.416570898640997 1978 604802 SGTC_779 1360-0071 233 µM 0.210426264980102 0.413910323064932 no 1361 0.4166674975215 2077 7566 SGTC_2957 9076800 11.52 µM 0.210257132399353 0.413970251825693 no 1362 0.41673349539748 1890 16459615 SGTC_2857 9024691 58.44 µM 0.21025692171347 0.413970326479289 no 1363 0.416733577611495 1912 16478292 SGTC_1661 st013063 9.66 µM 0.20865737272369 0.414537193705018 no 1364 0.417357859620453 1935 721395 SGTC_37 0566-0070 1.56 µM 0.207675200112413 0.414885356037309 no 1365 0.417741291468693 2015 1626686 SGTC_836 0330-0104 1.35 µM 0.206424635134734 0.415328755318807 no 1366 0.418229614570464 2021 46494820 SGTC_1225 1216-0074 20.6 µM 0.204096138911189 0.416154631962394 no 1367 0.419139185768714 1914 4241466 SGTC_223 busulfan 5 mM 0.199091530936921 0.417930927293197 no 1368 0.42109557297718 2018 2478 A DNA alkylator. SGTC_2806 7952793 58.44 µM 0.19857611568104 0.418113960420434 no 1369 0.421297169222048 1971 2972490 SGTC_1198 1612-1005 86.7 µM 0.19833830679026 0.418198416570266 no 1370 0.421390191238705 2039 6998509 SGTC_1158 4092-0494 91.8 µM 0.197189091589611 0.418606605330058 no 1371 0.421839783338922 2024 1148199 SGTC_2360 9040895 200 µM 0.196398303844048 0.418887535488666 no 1372 0.422149211872736 1924 4914414 SGTC_1203 3992-3522 103 µM 0.196169970336908 0.418968659481814 no 1373 0.422238565786589 2107 5322312 SGTC_2560 caryophyllene 100 µM 0.196130619763386 0.418982640588628 no 1374 0.42225396527898 2025 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2825 7998094 58.44 µM 0.195542786409884 0.419191507680005 no 1375 0.422484022701554 1964 2987815 SGTC_2066 5222451 176 µM 0.194991013691344 0.419387582543732 no 1376 0.422699991315901 2024 2281147 SGTC_332 4112-0506 40.9 µM 0.19429652102818 0.419634402018119 no 1377 0.422971854773821 1958 2790355 SGTC_3238 9133470 49.47 µM 0.1937142888464 0.419841349008173 no 1378 0.423199801446668 2076 3534688 SGTC_3133 9127736 49.47 µM 0.192408191953755 0.420305665020241 no 1379 0.423711238019063 2115 27243420 SGTC_1430 4049-0248 69.1 µM 0.190921955139797 0.420834155473624 no 1380 0.42429336942397 2063 22774488 SGTC_1338 1486-1223 76 µM 0.190552814793883 0.420965440126685 no 1381 0.424437980513704 2030 3444526 SGTC_1141 3253-0389 52.6 µM 0.190511166828823 0.420980252764975 no 1382 0.424454296783488 2063 5402031 SGTC_1387 3342-1166 1.8 µM 0.189957688545348 0.421177115099747 no 1383 0.424671143212418 1967 3418228 SGTC_953 1188-0045 9.7 µM 0.189878162732693 0.421205402630612 no 1384 0.424702302386463 1996 6144426 SGTC_574 1315-0397 40 µM 0.189103547783029 0.421480956363263 no 1385 0.425005830463583 2047 6794277 SGTC_2682 pyrogallin 40.03 µM 0.188376152859226 0.421739747533832 no 1386 0.425290896150454 2043 822798 An ATP competetive kinase inhibitor. SGTC_1613 st002381 52.1 µM 0.186804794156225 0.422298917761193 no 1387 0.425906843947366 2114 551167 SGTC_795 0685-0265 78 µM 0.185923352017355 0.422612648851093 no 1388 0.426252434607663 2099 302754 SGTC_739 1486-1183 203 µM 0.18476466293994 0.423025134911607 no 1389 0.426706812744365 2099 4346692 SGTC_3307 9126885 69.2785 µM 0.184338923129639 0.423176716846158 no 1390 0.426873790426416 1912 24824909 SGTC_184 1494-0393 24.714 µM 0.183752767869836 0.423385432278055 no 1391 0.427103705436508 1928 3090647 SGTC_1482 3346-2049 8.48 µM 0.183554499510976 0.423456035619978 no 1392 0.427181480324097 2056 3826804 SGTC_231 b-estradiol 524 µM 0.183015785915535 0.423647883880126 no 1393 0.427392816221857 1951 450 A steroid. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.182131956500754 0.42396267498213 no 1394 0.427739585238573 2040 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2127 5253358 187.912 µM 0.181394638107344 0.424225320788513 no 1395 0.428028913619269 1965 20612 SGTC_2485 5633444 17.78 µM 0.179640437243296 0.424850333133861 no 1396 0.428717428365693 1927 5724239 SGTC_3023 9089636 49.47 µM 0.176556297320867 0.425949652874751 no 1397 0.429928462188621 2144 17249241 SGTC_1615 st002656 86.5 µM 0.176364018566647 0.426018208423437 no 1398 0.430003985286047 2115 1584458 SGTC_123 0083-0120 66.675 µM 0.1763486333937 0.426023693988181 no 1399 0.430010028372841 1892 16001701 SGTC_2235 salicylic acid 500 µM 0.173712136759047 0.426963944205476 no 1400 0.4310458493964 2105 338 A COX inhibitor and kinase inhibitor. SGTC_2551 apiole 73.87 µM 0.173234311130487 0.427134395101458 no 1401 0.431233627478267 2090 10659 A possible DNA adduct former. SGTC_3098 9119039 49.47 µM 0.17296962164296 0.427228821512502 no 1402 0.431337653045983 2124 17161528 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.172899413434766 0.42725386857589 no 1403 0.4313652463607 2060 2333 A French combination drug. SGTC_375 3970-0961 9.27 µM 0.172712895137658 0.427320411159944 no 1404 0.431438553633527 2028 2898222 SGTC_1044 1222-0021 1.78 µM 0.171998868919024 0.427575167458856 no 1405 0.43171920910968 2029 4306703 SGTC_1255 0566-0045 221 µM 0.170868692975601 0.427978462858309 no 1406 0.432163506993174 2016 2788469 SGTC_862 0452-0056 10.2 µM 0.169804794730174 0.428358176290774 no 1407 0.43258182802195 2090 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.16881821236806 0.428710354382289 no 1408 0.432969816268195 2084 16486 A toxic proline analog. SGTC_3144 9087057 49.47 µM 0.168364287607195 0.428872409971668 no 1409 0.433148350688417 2166 17249618 SGTC_2720 fluspirilene 36.88 µM 0.168218026125437 0.428924629310148 no 1410 0.433205880110192 2077 3396 An atypical antipsychotic. SGTC_2904 7225135 42.03 µM 0.168168885958804 0.428942173969259 no 1411 0.43322520886175 2124 4446116 SGTC_3275 9138069 49.47 µM 0.16745088243731 0.429198540886418 no 1412 0.433507645953277 2020 17617007 SGTC_2363 9053361 176 µM 0.165927627121928 0.42974252594072 no 1413 0.434106952779421 2113 6469797 YMR079W SEC14 SGTC_650 1328-0195 38 µM 0.165906386269539 0.429750112421097 no 1414 0.434115310816222 2126 2780821 SGTC_999 SEC7.066 22.7 µM 0.165121820627796 0.430030349639828 no 1415 0.434424049187901 2023 740511 YDR170C SEC7 SGTC_1489 4065-0444 182 µM 0.163083708913692 0.430758502524252 no 1416 0.435226263237895 2122 2877968 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.163064951407209 0.430765205085594 no 1417 0.435233647558139 2022 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1915 st067105 30.6 µM 0.160969064227974 0.431514247088505 no 1418 0.436058883017128 2085 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1183 1254-0324 198 µM 0.160210292452642 0.431785482831792 no 1419 0.43635771095883 2075 5799357 SGTC_1337 1486-1011 40.3 µM 0.159874287194132 0.431905603849388 no 1420 0.436490051903282 2145 X1337 SGTC_1571 st070080 73.4 µM 0.159391033427935 0.432078376867065 no 1421 0.436680401445091 2079 4315245 SGTC_2722 naftopidil 47.16 µM 0.159281442004462 0.432117559830788 no 1422 0.436723570614374 2103 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2619 obliquin 87.91 µM 0.158315990396551 0.43246277309095 no 1423 0.437103904263745 2076 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2639 lactacystin 53 µM 0.158123151271517 0.432531732109896 no 1424 0.437179879013213 2090 3870 A proteasome inhibitor. SGTC_676 falcarinol 140 µM 0.158024231188615 0.4325671065998 no 1425 0.437218852442017 2134 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_168 3970-0862 530.542 µM 0.156955440395643 0.432949347817624 no 1426 0.437639983077907 2045 3135186 SGTC_1471 k673-0312 37 µM 0.156693527192336 0.433043027766383 no 1427 0.437743194308266 2138 24099884 SGTC_651 3253-0966 34.4 µM 0.156682131468679 0.433047103823556 no 1428 0.437747685077892 2045 781462 SGTC_3019 9081971 49.47 µM 0.154533298847093 0.433815831655675 no 1429 0.438594628932848 2132 16451803 SGTC_1334 1486-0610 236 µM 0.153163510527489 0.43430599343835 no 1430 0.439134666237737 2082 3742339 SGTC_3224 9130643 49.47 µM 0.15234887051918 0.434597550224511 no 1431 0.439455890822975 2067 17644395 SGTC_1234 0326-0494 15.5 µM 0.151409770016767 0.434933695113298 no 1432 0.439826241477488 2119 1547813 SGTC_3214 9129694 49.47 µM 0.15079139367806 0.43515506458063 no 1433 0.4400701377428 2130 17158655 SGTC_1372 2752-0194 270 µM 0.149791493692732 0.435513056774397 no 1434 0.440464560344002 2106 823334 SGTC_2232 chlorophetanol 41.5365 µM 0.149558049391078 0.435596643992405 no 1435 0.440556653783449 2143 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1106 tegaserod maleate 11.7 µM 0.147476932168522 0.436341936909483 no 1436 0.441377793047576 2049 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1824 st053723 68.6 µM 0.14510544912993 0.437191491522898 no 1437 0.442313808021709 1995 675225 SGTC_3338 9144300 39.5675 µM 0.145024776436896 0.437220396639453 no 1438 0.442345654909568 2083 4901274 SGTC_3049 9092223 49.47 µM 0.142261991480759 0.438210506829292 no 1439 0.443436533761459 2069 8623917 SGTC_2545 solidagenone 89.61 µM 0.141852060901703 0.438357448387021 no 1440 0.443598430576252 2138 6708572 An anti ulcer agent SGTC_1288 0973-0013 65.5 µM 0.141352844714609 0.438536406268478 no 1441 0.443795602305662 2070 4315430 SGTC_2766 oltipraz 83.91 µM 0.139776691774171 0.439101504292444 no 1442 0.444418214875722 2145 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3003 9075612 71.4286 µM 0.139021428637783 0.439372332807948 no 1443 0.444716607934933 2075 6501993 SGTC_1545 lovastatin 49.4 µM 0.138670384174412 0.439498222910096 no 1444 0.444855310977114 2065 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1502 4534-4282 27.7 µM 0.136791034736274 0.440172291124969 no 1445 0.445597985136042 2058 3278949 SGTC_1636 st007707 68.9 µM 0.13666724844909 0.440216695790521 no 1446 0.445646909260882 2136 403051 SGTC_1091 telmisartan 47.6 µM 0.136291695369744 0.440351418937482 no 1447 0.445795344380161 2135 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1431 4049-0260 9.09 µM 0.136025344960713 0.4404469717089 no 1448 0.445900622400291 2095 3854841 SGTC_379 3970-0972 5.9 µM 0.135499095014835 0.44063577320185 no 1449 0.446108639866312 2070 2898042 YBL034C STU1 SGTC_478 N-arachidonylglycine 10 µM 0.135401266345982 0.440670872459164 no 1450 0.446147311477211 2174 5283389 SGTC_1726 st035556 14.5795 µM 0.135157669258666 0.440758272962829 no 1451 0.446243607476731 2148 5919439 SGTC_450 aminopyrene 156 nM 0.132116648877932 0.441849606007277 no 1452 0.447446013722506 2169 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3226 9131256 49.47 µM 0.130473580183923 0.442439439454264 no 1453 0.448095877702842 2165 17178073 SGTC_197 4544-0043 41.561 µM 0.129413032930765 0.442820225561068 no 1454 0.448515417806358 2184 896523 SGTC_1369 1866-0067 208 µM 0.124549934453132 0.44456697670065 no 1455 0.450439933080293 2166 3531355 SGTC_1308 1187-1617 41.4 µM 0.124197296792726 0.444693681085452 no 1456 0.450579531257858 2111 2882570 SGTC_3177 9107506 49.47 µM 0.120684865967941 0.445956020549216 no 1457 0.451970323289364 2189 8897194 SGTC_342 k048-0088 23.3 µM 0.118322809277313 0.446805233749706 no 1458 0.452905942578746 2136 6820570 SGTC_3343 9148379 18.9835 µM 0.11710614292149 0.447242748477445 no 1459 0.453387970943063 2207 1955036 SGTC_404 fumagillin 50 µM 0.115740967486187 0.447733743673303 no 1460 0.453928918529538 2083 12015870 A methionine aminopeptidase binder. SGTC_1881 5652484 16 µM 0.114389514772768 0.448219882290314 no 1461 0.454464512718261 2214 2255129 SGTC_2070 5230947 200 µM 0.114149948858013 0.448306066021865 no 1462 0.454559463747387 2205 2835538 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.113995023518678 0.448361801643332 no 1463 0.454620869192811 2123 390807 SGTC_2002 4023503 131 µM 0.1134175354787 0.448569566525264 no 1464 0.454849769055313 2242 4736863 YCR052W RSC6 SGTC_1898 st060199 18.6 µM 0.11298588745407 0.448724871252857 no 1465 0.455020871872129 2168 688866 SGTC_977 1348-1378 135 µM 0.112617710515069 0.448857345622282 no 1466 0.455166821708097 2206 X977 SGTC_1432 4049-0298 68.4 µM 0.111840733697213 0.449136929665938 no 1467 0.455474844647039 2234 741646 SGTC_857 0438-0306 1.35 µM 0.110021628070146 0.449791607470107 no 1468 0.456196111160197 2129 4686136 SGTC_2678 equilin 100 µM 0.109529295243048 0.449968816674597 no 1469 0.456391343648567 2226 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1421 4029-0249 71.4 µM 0.108785929376301 0.450236401057208 no 1470 0.456686142154913 2235 2894095 SGTC_3204 9114183 49.47 µM 0.105691417064441 0.451350553479965 no 1471 0.457913595199022 2127 17027248 SGTC_3347 9188721 44.724 µM 0.105662636248909 0.451360917576804 no 1472 0.457925013149126 2132 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2592 piperlongumine 83.33 µM 0.104794111183798 0.451673692794882 no 1473 0.458269591457858 2107 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_767 0929-0023 86 µM 0.104330395015105 0.451840699611559 no 1474 0.458453578896164 2222 1204563 SGTC_2134 5324836 1.464 µM 0.104182292575044 0.451894040323146 no 1475 0.458512342987112 2161 699272 SGTC_1508 1080-0625 72.9 µM 0.102206932387253 0.45260557053419 no 1476 0.459296212662524 2223 767111 SGTC_1575 cyproterone acetate 48 µM 0.101787684532087 0.452756604432114 no 1477 0.459462600597381 2109 9880 An androgen receptor antagonist and liver toxin. SGTC_3113 9123498 49.47 µM 0.101585365636672 0.45282949219228 no 1478 0.459542897940475 2246 8897275 SGTC_1913 st060213 96.1 µM 0.100516453177639 0.45321460679363 no 1479 0.459967160621313 2217 688959 SGTC_61 0978-8327 98.565 µM 0.100335849885638 0.453279680055725 no 1480 0.460038848496494 2240 6150059 YHR072W ERG7 SGTC_2610 ononetin 44.17 µM 0.0993376971385242 0.453639347549077 no 1481 0.46043507421807 2135 259632 SGTC_1709 st033179 39.1045 µM 0.0984429393999494 0.453961790728343 no 1482 0.460790289766793 2240 573381 SGTC_484 loperamide 105 µM 0.0979285553874637 0.45414717266285 no 1483 0.460994512520467 2241 3955 An opioid-receptor agonist. SGTC_1690 st023502 41.2 µM 0.0973596046007215 0.45435223187754 no 1484 0.461220411568612 2242 24207482 SGTC_974 1326-0144 138 µM 0.095792845930859 0.4549169801755 no 1485 0.461842549675304 2112 5411856 SGTC_154 3389-1638 511.116 µM 0.0949395007308013 0.455224612381724 no 1486 0.462181440579227 1981 5238686 SGTC_2234 tolnaftate 200 µM 0.0933974268244727 0.455780600286627 no 1487 0.462793917340339 2251 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1901 st060216 58.6 µM 0.0926637738156392 0.456045146094212 no 1488 0.463085338724444 2240 688792 SGTC_583 1488-1091 88.9 µM 0.0924181740412352 0.456133710563007 no 1489 0.463182900212514 2258 4303273 SGTC_1127 asiatic acid 681.4 nM 0.0922067165314066 0.456209964911983 no 1490 0.46326690088044 2123 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1410 3909-8106 77.9 µM 0.0918551280077053 0.456336755909712 no 1491 0.463406571668755 2224 1039210 SGTC_443 clozapine 122 µM 0.0917219828167231 0.456384772323167 no 1492 0.463459465625384 2252 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1306 1185-0270 9.02 µM 0.0906548498957125 0.45676963752838 no 1493 0.463883423701884 2219 1548076 SGTC_2247 cerulenin 830 nM 0.0890565097468191 0.457346160220929 no 1494 0.464518500099218 2230 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2250 alverine citrate 130 µM 0.0877316384314679 0.457824110567235 no 1495 0.465044986368121 2209 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1294 1000-1494 117 µM 0.087688523847926 0.457839665280024 no 1496 0.465062120564291 2157 712797 YDL207W GLE1 SGTC_866 0495-0101 262 µM 0.0876700484396087 0.457846330786186 no 1497 0.465069462908792 2043 635694 SGTC_1436 4092-1007 8.32 µM 0.0874523452739721 0.457924874018072 no 1498 0.46515598160162 2240 2881121 SGTC_1974 st069448 26.9 µM 0.0864344201295831 0.458292144131673 no 1499 0.465560542998831 2259 6323587 YNR016C ACC1 SGTC_82 0054-0107 293.755 µM 0.086425306376345 0.458295432559518 no 1500 0.465564165305498 2259 3104697 SGTC_1392 3455-1037 33.9 µM 0.0860368874401344 0.458435584675326 no 1501 0.465718546996528 2223 981132 SGTC_334 1502-1024 68.5 µM 0.0857675375539234 0.458532776474775 no 1502 0.465825606318888 2162 3296216 SGTC_2143 5623677 140.463 µM 0.0857048664786441 0.4585553909651 no 1503 0.465850516737656 2246 5375313 SGTC_2792 7535235 81.82 µM 0.0855513600866996 0.458610783413764 no 1504 0.465911532826834 2142 1281891 SGTC_898 1000-0849 28.3 µM 0.0848173165576601 0.458875672521373 no 1505 0.466203313263291 2249 6751807 SGTC_3138 9097216 49.47 µM 0.0847965544943259 0.45888316504674 no 1506 0.466211566395598 2295 25237486 SGTC_2698 st077697 67.5 µM 0.0840052858616917 0.459168725576863 no 1507 0.466526114558238 2153 3154499 SGTC_1621 st003705 32.4 µM 0.0822508261802072 0.4598019665665 no 1508 0.467223628441123 2256 24207032 SGTC_295 k015-0027 31 µM 0.0820375135377837 0.459878964953018 no 1509 0.467308441245545 2196 3887424 SGTC_2482 5981709 142.65 µM 0.0818179125694025 0.459958234776681 no 1510 0.4673957558299 2211 877755 SGTC_2900 5328528 85.29 µM 0.0810321780855428 0.460241876020341 no 1511 0.467708181114342 2239 795359 SGTC_546 peri-Naphthalide 147 µM 0.080301581968711 0.460505631094476 no 1512 0.46799870002504 2223 223824 A penicillin ester. SGTC_728 3030-5151 22.5 µM 0.0800448223488334 0.460598328920705 no 1513 0.46810080361736 2243 3125388 SGTC_3294 9122953 26.2835 µM 0.0799817492286092 0.460621100512703 no 1514 0.468125885733693 2262 16459826 SGTC_1171 0368-0077 21.4 µM 0.079638209286114 0.460745132656022 no 1515 0.46826250254803 2197 3239779 SGTC_509 pifithrin 175 µM 0.07963636080758 0.460745800043649 no 1516 0.468263237649529 2274 4817 A p53 inhibitor. SGTC_1899 st063254 59.6 µM 0.0792599257935091 0.460881713077054 no 1517 0.468412940283182 2238 3093813 SGTC_423 5-fluorouracil 457 µM 0.0790160573321455 0.460969764984158 no 1518 0.468509925546328 2230 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_808 0711-0032 135 µM 0.0782454915622221 0.461248000419499 no 1519 0.468816387940675 2261 4252555 SGTC_1473 k844-0725 134 µM 0.0781981573717778 0.461265092440982 no 1520 0.468835213867694 2270 54682906 SGTC_2620 irigenin 100 µM 0.0771987605333853 0.461625983804784 no 1521 0.46923271382853 2230 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2838 9002687 71.43 µM 0.0769591632324186 0.461712509294761 no 1522 0.469328015798593 2183 6457060 SGTC_2760 etidronate 98.04 µM 0.0748896440253169 0.462459947315061 no 1523 0.470151258144676 2251 3305 A chelator and antioxidant. SGTC_604 1000-0114 314 µM 0.0740919999660425 0.462748064016874 no 1524 0.470468590433972 2285 1572745 SGTC_1173 0443-0020 122 µM 0.0732375861979441 0.463056708159898 no 1525 0.470808528610759 2210 5331295 SGTC_3072 9116419 49.47 µM 0.0726148418671158 0.46328167922093 no 1526 0.471056307899469 2208 17170162 SGTC_1302 1159-0335 255 µM 0.0724418437545404 0.463344178174211 no 1527 0.471125142874224 2239 649284 SGTC_1773 st048542 73.5835 µM 0.072035390093515 0.463491021069686 no 1528 0.471286871887738 2201 3237138 SGTC_2726 cimetidine 79.27 µM 0.0717556197108667 0.46359209893481 no 1529 0.471398196034468 2278 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_992 3909-8734 162 µM 0.0717361407857746 0.463599136537038 no 1530 0.471405947026566 2223 4288319 SGTC_1025 k007-0731 70 µM 0.0712973402641533 0.463757675174593 no 1531 0.471580556003064 2238 6256118 SGTC_347 4534-1311 26.2 µM 0.0700411150384964 0.464211581112862 no 1532 0.472080467452817 2275 2862016 SGTC_1386 3228-0095 33.8 µM 0.0683308068110417 0.464829633492283 no 1533 0.472761150571445 2260 870181 SGTC_2208 7283366 200 µM 0.0676570281218446 0.46507313960939 no 1534 0.473029328739084 2268 898663 SGTC_1249 0481-0015 10.2 µM 0.0671046761844744 0.465272771408644 no 1535 0.473249185616036 2260 4227577 SGTC_3342 9147791 14.508 µM 0.0667944187727718 0.465384908907189 no 1536 0.473372683331188 2280 1838168 SGTC_1343 1487-0095 224 µM 0.0665684253088227 0.465466592302291 no 1537 0.473462641460924 2284 4560101 YGL055W OLE1 SGTC_1148 3909-7663 27.7 µM 0.0652220567049265 0.465953255699995 no 1538 0.473998599902799 2290 4084526 SGTC_36 0335-0881 14.2 µM 0.0621569189801789 0.467061380531401 no 1539 0.475218934894645 2263 23828853 SGTC_2120 5538279 151.968 µM 0.0620193916372212 0.467111106194619 no 1540 0.475273694716746 2256 2058197 SGTC_2708 st078559 56 µM 0.0613011652658594 0.467370803113387 no 1541 0.475559681400724 2298 17250902 SGTC_2399 5884133 200 µM 0.0610277074818296 0.467469683874646 no 1542 0.475668571398175 2234 722445 SGTC_1647 st011722 22.4 µM 0.0602825375730818 0.467739143196321 no 1543 0.475965304823999 2281 2854783 SGTC_3055 9094636 49.47 µM 0.0586121867198703 0.468343208774668 no 1544 0.476630501886675 2261 25236176 SGTC_1485 3909-9022 254 µM 0.0584564119916986 0.468399546874995 no 1545 0.476692540640229 2285 714516 SGTC_3085 9117376 49.47 µM 0.057832946049103 0.468625038341762 no 1546 0.476940847467822 2201 16480349 SGTC_1720 st037298 9.481 µM 0.0577014546895142 0.468672596645044 no 1547 0.476993217477038 2250 597396 SGTC_372 0155-0182 15.9 µM 0.0572306340823192 0.468842888523765 no 1548 0.477180737837657 2225 771486 SGTC_2699 st077704 54.6 µM 0.0569709641687779 0.468936811402233 no 1549 0.477284162399358 2258 645852 SGTC_1263 0774-1208 64.8 µM 0.0567210357840306 0.469027212392339 no 1550 0.47738370842895 2297 906585 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.05579754705387 0.469361259076931 no 1551 0.477751544534497 2289 5357218 A potent inhibitor of glutathione S-transferases. SGTC_685 1278-0033 54.9 µM 0.0555595197323282 0.469447362428423 no 1552 0.47784635661934 2283 3590572 SGTC_1553 gossypol 38.6 µM 0.0554543355250216 0.469485411930985 no 1553 0.477888254453094 2293 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1973 st070275 50.2 µM 0.0545360905913399 0.469817591111957 no 1554 0.478254027614017 2300 17118334 SGTC_656 4090-1979 187 µM 0.0544876383392357 0.469835119514738 no 1555 0.478273328567836 2310 22330961 SGTC_1554 st069299 38.7 µM 0.054101018854559 0.469974987592837 no 1556 0.478427340254833 2254 24207999 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0538379923932422 0.470070145302632 no 1557 0.478532119923379 2286 6708514 SGTC_10 0279-0212 42.575 µM 0.053659520548367 0.470134713818088 no 1558 0.478603217116494 2314 39851 YBR002C RER2 SGTC_1570 verbenone 133 µM 0.0518934778141128 0.470773684431959 no 1559 0.479306785612883 2329 29025 A natural terpanoid with antifungal properties. SGTC_3116 9124943 49.47 µM 0.0517257036916596 0.470834390602781 no 1560 0.479373628033242 2281 41905195 YPL160W CDC60 SGTC_2035 5154463 94.595 µM 0.0508676895026665 0.471144858795661 no 1561 0.4797154761028 2311 2769623 SGTC_3006 9075424 71.4286 µM 0.0484414438052483 0.472022878102018 no 1562 0.480682215337882 2274 7465181 SGTC_196 k015-0023 18.111 µM 0.0482636993641411 0.472087206354863 no 1563 0.480753042266381 2273 5211998 SGTC_2716 st080858 38.6235 µM 0.0470553670750965 0.47252453828944 no 1564 0.481234549909622 2324 5296050 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0462263167295245 0.472824615830559 no 1565 0.481564933587037 2310 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1085 doxorubicin 7.67 µM 0.0453386002875057 0.473145944856284 no 1566 0.481918710238952 2333 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1638 st008370 60.6 µM 0.0450032964574318 0.473267320212574 no 1567 0.482052340712574 2342 24207134 SGTC_2657 nystatin 74.44 µM 0.0446982046714189 0.473377761382987 no 1568 0.482173932367156 2295 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2315 7733312 200 µM 0.0415010187398436 0.474535242621571 no 1569 0.483448240359204 2308 726316 SGTC_1468 k284-1086 134 µM 0.0411070910977492 0.474677871813838 no 1570 0.483605260752543 2317 15996457 SGTC_455 paf C-16 10 µM 0.0410349505982767 0.474703992041982 no 1571 0.483634016384761 2322 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1040 k898-0338 155 µM 0.0405676706772239 0.474873184767719 no 1572 0.483820278995758 2333 20969351 SGTC_2906 7926292 26.41 µM 0.0400358399557976 0.475065755560921 no 1573 0.484032276517602 2280 2966319 SGTC_1479 0549-0158 134 µM 0.0389575188349564 0.47545622310756 no 1574 0.484462128970687 2332 5440202 SGTC_3280 9140961 49.47 µM 0.0383586563406674 0.475673085569725 no 1575 0.484700862082497 2311 4901226 SGTC_3083 9117465 49.47 µM 0.0376856763470507 0.475916796351242 no 1576 0.484969148251986 2191 16420915 SGTC_2090 5301565 104.445 µM 0.0372087882195029 0.47608950052322 no 1577 0.485159265740122 2331 2056344 SGTC_144 4161-2749 112.381 µM 0.0363159458195723 0.476412853833953 no 1578 0.485515217700601 2327 797501 YMR168C CEP3 SGTC_908 3448-7491 47.7 µM 0.0359878629600136 0.476531676789896 no 1579 0.485646018320632 2312 1203031 SGTC_261 5-fluorouridine 15.376 µM 0.0351454459918819 0.476836787523257 no 1580 0.485981881558528 2339 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3159 9100096 49.47 µM 0.0336365645921543 0.47738331545907 no 1581 0.486583482213784 2353 25236875 SGTC_2104 5389443 200 µM 0.0330248566527803 0.477604892748514 no 1582 0.486827382853589 2325 2244536 SGTC_3112 9123419 49.47 µM 0.0327272732579533 0.477712688073063 no 1583 0.48694603731098 2359 17015854 SGTC_1724 st037281 8.293 µM 0.0323560877539877 0.477847146992476 no 1584 0.487094040515976 2331 574124 YDL195W SEC31 SGTC_1191 1487-1166 10.6 µM 0.0309277509388095 0.478364573732837 no 1585 0.487663579228209 2321 3955771 SGTC_2880 9042983 58.44 µM 0.0290897176059189 0.479030469938929 no 1586 0.488396518245416 2319 6464714 SGTC_491 tetrandrine 80.3 µM 0.0277975880928767 0.479498627251877 no 1587 0.488911794821888 2339 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_60 0986-0278 202 µM 0.026100335276886 0.480113609502257 no 1588 0.48958865482126 2307 3110598 SGTC_2731 amoxapine 43.43 µM 0.0255985979170981 0.480295418049386 no 1589 0.489788752202442 2361 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2820 7989630 71.43 µM 0.0255655633052353 0.480307388549574 no 1590 0.489801926794116 2361 2984098 SGTC_3212 9128307 49.47 µM 0.0249634847451111 0.480525562262982 no 1591 0.490042044738835 2293 27243542 SGTC_3175 9106517 49.47 µM 0.0244175238476698 0.480723405803527 no 1592 0.490259785241859 2339 41468073 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0239881136835081 0.480879017405552 no 1593 0.490431044943366 2326 6857784 SGTC_2788 5282734 71.43 µM 0.0239699754650861 0.480885590479677 no 1594 0.490438278965525 2361 743706 SGTC_1150 3909-7983 10.9 µM 0.0237738654666792 0.480956658736689 no 1595 0.490516493246268 2346 23965914 SGTC_1265 0819-1001 68.8 µM 0.0229232723120097 0.481264911970182 no 1596 0.490855738325568 2365 3106768 SGTC_1849 st056239 19.2 µM 0.0226585220967943 0.481360859205653 no 1597 0.490961330952568 2339 5393181 SGTC_961 1252-1571 372 µM 0.0217885269856998 0.481676158782995 no 1598 0.491308323077495 2363 6813498 SGTC_8 0354-0001 70 µM 0.0195510606367105 0.482487103091649 no 1599 0.492200752157735 2365 4993152 SGTC_178 4092-0806 87.505 µM 0.0193158666756064 0.482572350743029 no 1600 0.492294563256699 2376 2169044 SGTC_917 harmaline 728.087 nM 0.0191961044673261 0.482615759676648 no 1601 0.492342332608056 2348 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_853 0419-0306 21 µM 0.0191312464586109 0.482639268155172 no 1602 0.492368202459209 2357 762713 SGTC_209 4077-0173 175.592 µM 0.0185867788857734 0.482836618618993 no 1603 0.492585374968162 2326 15993494 SGTC_2157 5649910 96.377 µM 0.018474676563542 0.482877252316028 no 1604 0.49263008964631 2364 2858091 SGTC_2357 9067248 200 µM 0.0178835994775656 0.48309150279141 no 1605 0.492865856322021 2339 9150235 SGTC_2994 9053520 71.4286 µM 0.0177373747956297 0.483144506291414 no 1606 0.492924182278409 2372 4647384 SGTC_3119 9125183 49.47 µM 0.0160619790017783 0.483751824525405 no 1607 0.493592472980415 2377 22695334 SGTC_1675 st018485 24.5 µM 0.0158672540308319 0.483822413318806 no 1608 0.49367014710526 2301 3323024 SGTC_2295 7971645 200 µM 0.0156102039425658 0.483915596060647 no 1609 0.493772682553177 2355 2978226 YKL099C UTP11 SGTC_725 1497-0963 19 µM 0.0155107829082894 0.483951637227816 no 1610 0.493812341005774 2375 3549977 SGTC_1425 4048-4433 7.33 µM 0.0153890752732259 0.483995757699881 no 1611 0.493860889532599 2377 23734946 SGTC_2971 9092186 9.93 µM 0.01517209867228 0.484074414796231 no 1612 0.493947440567139 2363 25236400 SGTC_1443 4112-3303 14 µM 0.0146828852631263 0.48425176386736 no 1613 0.494142586734821 2380 704433 SGTC_3259 9138485 49.47 µM 0.0123780234041205 0.48508736101745 no 1614 0.495062009212711 2379 17646153 SGTC_548 1436-0017 110 µM 0.012042044719526 0.485209171197212 no 1615 0.49519603532367 2388 9677137 SGTC_644 1498-1197 63.3 µM 0.0113790968621684 0.485449529166286 no 1616 0.495460495114534 2368 6741615 SGTC_2328 6201408 200 µM 0.0112879515928993 0.485482575154613 no 1617 0.495496854480858 2378 2890418 SGTC_921 1561-0023 372 µM 0.00966527337633679 0.486070916244023 no 1618 0.496144173832247 2392 24050882 SGTC_772 k072-0172 35.3 µM 0.00920320818798727 0.486238454714567 no 1619 0.496328502967261 2382 5861980 SGTC_783 0848-0141 92.7 µM 0.00919474457083379 0.486241523528271 no 1620 0.496331879319131 2385 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1329 1447-1697 50.6 µM 0.00907569855921794 0.486284688377905 no 1621 0.496379369824813 2349 2840515 SGTC_2341 7987486 176.74 µM 0.00903080449096237 0.486300966543381 no 1622 0.496397279232823 2387 1258686 SGTC_876 0720-0963 56.8 µM 0.0085221936600525 0.486485385618416 no 1623 0.496600177780879 2386 765861 SGTC_1884 5633444 25 µM 0.00630293148978987 0.487290109367449 no 1624 0.49748551078709 2388 5724239 SGTC_1469 k284-2957 126 µM 0.00616133717223641 0.487341454488501 no 1625 0.497541997650008 2375 23884841 SGTC_2376 9072922 81.32 µM 0.00572800098917062 0.487498592735582 no 1626 0.497714870719092 2376 17087968 SGTC_322 k048-0136 19.3 µM 0.0055796305405055 0.487552395918759 no 1627 0.497774061018137 2370 6823282 SGTC_1782 st039423 80.636 µM 0.00534703794100968 0.487636740813201 no 1628 0.497866850655172 2392 2068169 SGTC_2465 5809242 33.21 µM 0.00478472168744631 0.487840655446744 no 1629 0.49809117950221 2397 2731748 SGTC_202 3594-0513 34.79 µM 0.00417367454028036 0.488062245130273 no 1630 0.498334949595323 2387 708429 SGTC_3333 9141820 12.094 µM 0.000996071764033087 0.489214626509152 no 1631 0.499602624924723 2403 1939433 SGTC_515 4092-1064 102 µM 0.000642547501431326 0.48934284046558 no 1632 0.499743660652152 2404 717353 SGTC_1296 1068-0102 11.9 µM 0.000185755668767101 0.489508508483835 no 1633 0.499925894210331 2403 767053 SGTC_2811 7967822 32.47 µM -0.000209693724803525 0.489651930456111 no 1634 0.499916344307854 2407 2232244 SGTC_3301 9125354 19.7965 µM -0.00120306796322161 0.490012214256119 no 1635 0.499520045439053 2409 41905162 SGTC_2416 tofa 880 nM -0.00130772979984736 0.490050174210413 no 1636 0.499478291440201 2410 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_854 0422-0053 192 µM -0.00149779550140862 0.490119109647333 no 1637 0.49940246627051 2409 3596728 SGTC_2849 9019321 12.99 µM -0.00251269170501648 0.49048721000729 no 1638 0.498997582096069 2416 16489627 SGTC_2793 7325131 81.82 µM -0.00290742171556722 0.490630379818097 no 1639 0.498840108184817 2413 4176441 SGTC_1730 st033808 45.1 µM -0.00317899674390857 0.49072888163332 no 1640 0.49873176592573 2419 1045166 SGTC_1402 3909-7673 35.9 µM -0.00389261117863689 0.490987716347444 no 1641 0.498447076741438 2408 5328014 SGTC_2511 berberine 10.47 µM -0.00443151984650569 0.491183186146295 no 1642 0.498232085153286 2414 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1521 st012942 49.4 µM -0.00462926793415017 0.491254912709127 no 1643 0.498153195889969 2418 24207259 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.00465607409452963 0.491264635776913 no 1644 0.498142501894471 2420 279621 SGTC_2569 tetrandrine 100 µM -0.00511600217635499 0.491431460618535 no 1645 0.497959019328491 2417 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3291 9121177 71.43 µM -0.00565841917301315 0.491628207714413 no 1646 0.497742629397629 2427 17015612 SGTC_2565 isoliquiritigenin 100 µM -0.00618649572396929 0.491819755158587 no 1647 0.497531961031294 2431 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_343 4130-2827 29.8 µM -0.00735809063119772 0.492244730538587 no 1648 0.497064573032282 2433 1118244 SGTC_3126 9127922 49.47 µM -0.00793872585402718 0.492455349012871 no 1649 0.496832939870814 2441 45595682 SGTC_2252 omeprazole 400 µM -0.00949189459060038 0.493018752551061 no 1650 0.496213338787326 2463 4594 A proton pump inhibitor. SGTC_679 0422-0091 41.4 µM -0.00980752251907668 0.493133246609962 no 1651 0.496087427324681 2429 627384 YHR062C RPP1 SGTC_713 1488-1073 324 µM -0.0102164342631614 0.493281580221016 no 1652 0.495924303318106 2421 3312542 SGTC_3148 9097893 49.47 µM -0.011837612120205 0.493869674904333 no 1653 0.495277586317748 2430 17174100 SGTC_1442 4112-3290 3 µM -0.0134790819922799 0.494465144241327 no 1654 0.494622787119846 2423 704353 SGTC_624 k048-0052 28 µM -0.0142400227576588 0.494741191886465 no 1655 0.49431924483767 2439 6835531 SGTC_2311 7694451 200 µM -0.0144037439201351 0.49480058559666 no 1656 0.494253936242108 2447 2163142 SGTC_586 0957-0265 8.15 µM -0.0150665498836196 0.495041035244748 no 1657 0.493989543629034 2425 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3191 9110352 49.47 µM -0.0154318363552481 0.495173552938466 no 1658 0.493843832354533 2436 17122424 SGTC_689 0833-0039 98 µM -0.0159932608320006 0.49537722611024 no 1659 0.4936198840428 2440 5374726 SGTC_1268 0828-0275 2.46 µM -0.01643222349213 0.495536473513509 no 1660 0.49344478629356 2467 745337 SGTC_2783 7738165 71.43 µM -0.0169465672396415 0.495723068661711 no 1661 0.493239621403164 2441 17201110 SGTC_787 4152-0075 138 µM -0.0172478546644195 0.495832371043297 no 1662 0.493119442677604 2456 9566539 SGTC_2406 ethylparaben 405.7 µM -0.0189743483337596 0.496458721819739 no 1663 0.492430784394927 2451 8434 A possible steroid mimic. SGTC_3060 1327-0027 12.5 µM -0.0190802299395814 0.496497134670504 no 1664 0.49238855139133 2439 16000455 YPR107C YTH1 SGTC_2805 7950783 58.44 µM -0.0202033689314331 0.496904600862704 no 1665 0.491940570208224 2455 1178958 YDL195W SEC31 SGTC_2258 7960471 200 µM -0.0210554775900413 0.497213741510709 no 1666 0.491600700374514 2478 2974708 SGTC_78 0336-0123 156.75 µM -0.0215302579956869 0.497385990142848 no 1667 0.491411333331644 2452 6765896 SGTC_2267 7931562 200 µM -0.0217055156215851 0.497449573107205 no 1668 0.491341431990311 2442 934880 SGTC_1322 1348-1070 12 µM -0.0218010588281984 0.49748423593611 no 1669 0.491303324782939 2434 6758089 SGTC_614 0462-0418 107 µM -0.0225198310386635 0.497745005230649 no 1670 0.491016646564752 2438 5188303 SGTC_2455 5377712 9.75 µM -0.0228241801262832 0.497855422841482 no 1671 0.490895260047715 2489 2243908 SGTC_336 4111-0029 111 µM -0.0231287350514193 0.497965915294459 no 1672 0.490773792278562 2478 3131175 SGTC_1891 st059073 26.2 µM -0.0254994799782343 0.498826025658405 no 1673 0.489828281635394 2464 688754 SGTC_2257 7960413 200 µM -0.0256927544038118 0.498896146249159 no 1674 0.489751201549508 2487 2974689 YIL048W NEO1 SGTC_2131 toluylene red 5.2905 µM -0.0261515587406401 0.499062602088668 no 1675 0.489568226588811 2463 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_46 0329-0187a 2.197 µM -0.0271659258240787 0.499430618599424 no 1676 0.489163696461723 2446 46494817 SGTC_326 k292-0812 17.5 µM -0.0278232557960633 0.499669100869797 no 1677 0.488901558848963 2453 3579357 SGTC_508 roscovitine 141 µM -0.0285361141451398 0.499927729216073 no 1678 0.488617282413204 2448 160355 A CDKinase inhibitor. SGTC_2064 5220758 200 µM -0.0289345145932013 0.499927729216073 no 1679 0.488458409236778 2495 788518 SGTC_2853 9015042 58.44 µM -0.0290563672407425 0.499883520499936 no 1680 0.488409817494423 2464 6457456 SGTC_1829 berberine 14.4 µM -0.0299296744305207 0.499566680600666 no 1681 0.488061569836216 2502 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1750 st081859 2.357 µM -0.0302147214621068 0.499463264264872 no 1682 0.487947903931566 2468 5291695 SGTC_1424 4048-1941 275 µM -0.030414356936149 0.499390835644581 no 1683 0.487868297486858 2499 X1424 SGTC_1506 4226-2149 212 µM -0.0305990045281589 0.499323844711051 no 1684 0.487794668025416 2518 991114 SGTC_125 0133-0007 11.75 µM -0.0314736293853689 0.499006527375358 no 1685 0.48744591121247 2486 26541 SGTC_2830 7992007 71.43 µM -0.0323365124545723 0.498693470621549 no 1686 0.487101845846203 2460 1952075 SGTC_2114 5491910 81.25 µM -0.0325940542673904 0.498600033770389 no 1687 0.486999155660097 2502 2849228 SGTC_3185 9108267 49.47 µM -0.0330725338926038 0.498426440304046 no 1688 0.486808372771208 2484 4910486 SGTC_1911 st060208 74.3 µM -0.0332202674384062 0.498372842305534 no 1689 0.486749467981368 2501 688783 SGTC_929 2805-0021 398 µM -0.0333282991372085 0.498333648227699 no 1690 0.486706393421316 2544 3098024 SGTC_2801 7907800 81.82 µM -0.0334736765385862 0.498280905093059 no 1691 0.486648428571909 2490 6620925 SGTC_2388 9080168 200 µM -0.0335504375570951 0.498253056094919 no 1692 0.486617822547142 2470 15943073 SGTC_3044 9093193 49.47 µM -0.0340101757788453 0.498086262648302 no 1693 0.486434518149185 2508 25236277 SGTC_860 0443-0016 25.1 µM -0.0357558182232639 0.497452945269746 no 1694 0.485738531235408 2471 5337942 SGTC_1319 1306-0155 43.7 µM -0.0357811058268367 0.497443770995115 no 1695 0.485728449392505 2476 3122360 SGTC_1129 3453-1384 223 µM -0.0372739625762646 0.496902169139508 no 1696 0.485133282957886 2610 1084452 SGTC_1064 honokiol 6.76 µM -0.0374081638663123 0.496853481767243 no 1697 0.485079781702119 2508 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_533 1222-0222 6.71 µM -0.0391535795816579 0.496220260608664 no 1698 0.484383971680223 2623 3982874 SGTC_2522 biochanin a 4.94 µM -0.0392549216970428 0.49618349487575 no 1699 0.484343573083342 2500 5280373 A possible chelator. SGTC_895 0964-0006 13.7 µM -0.0392595746984574 0.496181806822091 no 1700 0.484341718234181 2471 6738897 SGTC_335 4077-0256 27.6 µM -0.0403980122859788 0.495768797312783 no 1701 0.483887907461649 2554 3121989 SGTC_3065 9113888 49.47 µM -0.0409974416172195 0.495551334384916 no 1702 0.483648967721379 2545 16648368 SGTC_3304 9125678 46.087 µM -0.0413517289572295 0.495422805485593 no 1703 0.483507747282314 2492 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_370 0180-0345 38.7 µM -0.0419019624922485 0.495223191874885 no 1704 0.483288425965567 2456 3989527 SGTC_1692 fluoroquinolonic acid 71 µM -0.042814719531604 0.494892064722296 no 1705 0.482924615129881 2575 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1381 2324-0066 62.1 µM -0.0434466350912406 0.494662822413938 no 1706 0.482672751673835 2527 10885928 SGTC_182 3448-4371 550.524 µM -0.044463639315744 0.494293883821683 no 1707 0.482267417459789 2462 3491403 SGTC_2188 6126565 140.678 µM -0.0451352580250379 0.49405024337877 no 1708 0.481999749104122 2488 874518 SGTC_483 fpl-64176 144 µM -0.0452227095424906 0.494018519101631 no 1709 0.481964896583939 2492 3423 SGTC_3052 9092717 49.47 µM -0.0456612365322107 0.493859437796728 no 1710 0.481790130165187 2550 25237534 SGTC_1464 k208-0027 110 µM -0.0457371617941454 0.493831895030042 no 1711 0.481759871980411 2478 X1464 SGTC_2167 5876490 200 µM -0.0468193874247916 0.493439308428523 no 1712 0.481328588523098 2662 686534 SGTC_1716 st033144 30.6155 µM -0.0476972691549223 0.493120853974568 no 1713 0.480978755263158 2501 674617 SGTC_622 1348-1566 26.3 µM -0.04970366924208 0.492393042601679 no 1714 0.480179266221659 2544 7340407 SGTC_969 1313-0238 134 µM -0.0501550520538333 0.492229309197744 no 1715 0.479999414854133 2506 5212874 SGTC_505 gw-5074 63.9 µM -0.050610757597027 0.492064009105872 no 1716 0.479817845244933 2591 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3145 9085516 49.47 µM -0.0508832716957215 0.491965159508117 no 1717 0.479709267746959 2559 25236195 SGTC_2781 5567276 71.43 µM -0.051300247672433 0.491813909914345 no 1718 0.479543135376009 2559 2853274 SGTC_2441 5730946 39.09 µM -0.0524312682431266 0.491403661088456 no 1719 0.479092529959213 2560 1774275 SGTC_621 3584-0052 32.1 µM -0.0529034062708256 0.491232407742552 no 1720 0.478904435193696 2502 2273927 SGTC_1119 parthenolide 318.541 nM -0.0544169733006881 0.490683419554414 no 1721 0.478301478076102 2650 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2335 9018011 154.17 µM -0.0574503563054792 0.489583230788851 no 1722 0.477093225338981 2585 6458208 SGTC_3218 9131285 49.47 µM -0.0581716414935231 0.489321636578648 no 1723 0.476805954634152 2531 17156417 SGTC_1081 sertraline 6 µM -0.058441360208751 0.489223816730567 no 1724 0.476698535184594 2513 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3196 9111891 49.47 µM -0.0586473050286181 0.489149126424599 no 1725 0.476616515767442 2487 18891510 SGTC_1960 st011366 51.8 µM -0.0588014270590087 0.489093231013515 no 1726 0.476555135900342 2510 3972846 SGTC_798 1287-0182 476 µM -0.059144633400564 0.488968761198045 no 1727 0.47641845426418 2510 1649755 SGTC_427 1354-0053 47.3 µM -0.0591646353843308 0.488961507159887 no 1728 0.476410488576412 2746 6813657 SGTC_919 tnp00227 403.569 nM -0.0598009644391432 0.48873073420657 no 1729 0.476157078721069 2551 1269246 A methoxyflavone. YNL221C POP1 SGTC_2641 levomentholum 100 µM -0.0602582726237551 0.488564887810381 no 1730 0.475974967572198 2508 16666 SGTC_2037 5169046 200 µM -0.0602810580665844 0.48855662454249 no 1731 0.475965893990238 2588 5718022 SGTC_2107 5363541 170.161 µM -0.0611439814425139 0.488243684216405 no 1732 0.475622271263831 2511 244052 SGTC_3203 9113543 49.47 µM -0.0622909316343953 0.487827752418676 no 1733 0.475165574980771 2633 17018012 SGTC_479 n-linoleoylglycine 10 µM -0.0650598130523154 0.486823696400143 no 1734 0.474063188574114 2528 6433346 An anti-infammatory. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0656318979547471 0.486616256297713 no 1735 0.473835446479669 2595 688751 SGTC_417 st075190 100 µM -0.0670397190671428 0.486105790690123 no 1736 0.473275041532347 2512 222757 SGTC_2586 curcumin 80 µM -0.0672469354161385 0.486030657464089 no 1737 0.473192560301422 2588 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1446 4239-0190 62 µM -0.0674195923683797 0.485968055283187 no 1738 0.473123836109751 2539 1340085 SGTC_1842 st055362 61.2 µM -0.0678868493378924 0.485798638385899 no 1739 0.472937853654837 2541 676032 SGTC_85 0868-0259 160.055 µM -0.0687174300456695 0.485497494797138 no 1740 0.472607271914782 2602 83173 SGTC_501 nsc-95397 161 µM -0.0700210734497249 0.485024849643655 no 1741 0.472088443307736 2642 262093 SGTC_250 brefeldin a 552.239 µM -0.07036757628719 0.484899226096468 no 1742 0.471950548814948 2517 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0705570665935399 0.484830527596807 no 1743 0.471875140551386 2617 6708760 SGTC_1955 wogonin 32.4 µM -0.070836900118079 0.484729076564741 no 1744 0.471763781764494 2755 5281703 A flavanone. SGTC_1165 k072-0275 30.3 µM -0.0729827221142084 0.483951162168728 no 1745 0.470909933297954 2538 6153523 YGL055W OLE1 SGTC_1227 3909-8010 46.6 µM -0.0747097353236067 0.483325120706272 no 1746 0.470222830827628 2557 15982272 SGTC_2186 6124449 200 µM -0.0751044797306655 0.483182031763721 no 1747 0.47006579179221 2596 3834182 YLR033W RSC58 SGTC_3222 9128301 49.47 µM -0.0754860273857095 0.483043728504834 no 1748 0.469914007173925 2565 4911358 SGTC_15 0266-0086 27.098 µM -0.0760197001226097 0.482850286426523 no 1749 0.469701712558433 2544 1712902 YIL048W NEO1 SGTC_998 3996-0085 177 µM -0.0772077350041812 0.482419670154573 no 1750 0.469229144186695 2587 715391 SGTC_1447 4239-0816 81.9 µM -0.0772990912925435 0.482386557908712 no 1751 0.469192806894755 2550 1341554 SGTC_2603 homopterocarpin 100 µM -0.0779407462211563 0.482153992398464 no 1752 0.468937593588996 2619 101795 A weak amylase inhibitor. SGTC_448 monastrol 171 µM -0.0813442351570643 0.480920513560346 no 1753 0.467584097978295 2571 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1591 genipin 88.4 µM -0.0817925342311139 0.48075805616308 no 1754 0.467405846501634 2704 442424 A DNA cross-linking agent. SGTC_2719 novobiocin 32.65 µM -0.0831603430527205 0.480262400988017 no 1755 0.466862022566383 2571 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0833439265754756 0.480195877825082 no 1756 0.466789036705545 2780 6710655 SGTC_2021 4019055 173 µM -0.0839395927648381 0.479980036559235 no 1757 0.466552230074502 2641 44827708 YER133W GLC7 SGTC_260 nsc-65238 3.989 µM -0.084226011110814 0.4798762541775 no 1758 0.46643836889362 2564 3246252 SGTC_757 1066-0008 322 µM -0.0844770021564722 0.479785309837765 no 1759 0.466338593545529 2711 6842497 SGTC_535 2293-4129 48.2 µM -0.0845036820532181 0.479775642679805 no 1760 0.466327987729754 2544 396118 YIL048W NEO1 SGTC_1830 st055982 50.3 µM -0.0848770026503706 0.479640375446317 no 1761 0.466179587512567 2546 455313 An antimicrobial agent. SGTC_2101 5377231 179.231 µM -0.086297626398648 0.479125654873724 no 1762 0.465614912649098 2622 2844213 SGTC_2218 6965428 192.983 µM -0.0887981037715321 0.478219766684901 no 1763 0.464621182355215 2570 675684 SGTC_2301 7769476 200 µM -0.0888544658157645 0.478199348778955 no 1764 0.464598785683368 2621 977820 SGTC_1567 st069303 68.4 µM -0.0899941131258013 0.477786508615099 no 1765 0.464145946446181 2641 5581319 SGTC_1056 3448-1962 115 µM -0.0908764838923322 0.477466883888688 no 1766 0.463795367997456 2642 715507 SGTC_94 0334-0113 514.748 µM -0.090937319489212 0.477444847696482 no 1767 0.463771198182786 2571 6795178 SGTC_1239 0337-0584 35.4 µM -0.0912235262644538 0.47734117728858 no 1768 0.463657490816961 2659 914301 YML130C ERO1 SGTC_1935 st074532 41.6 µM -0.0916875758225439 0.477173091563148 no 1769 0.463473134433352 2705 2829742 SGTC_2430 5571206 200 µM -0.0916932375264774 0.477171040833892 no 1770 0.46347088521491 2598 1731771 SGTC_496 calpeptin 138 µM -0.0925268910241034 0.476869089315933 no 1771 0.46313971345541 2651 73364 A calpain inhibitor. SGTC_1846 st056244 14.8 µM -0.0931367833923062 0.476648193077143 no 1772 0.462897447751846 2643 5393182 SGTC_661 1304-0007 33.6 µM -0.0939825984593142 0.476341860148782 no 1773 0.462561489981639 2600 3117130 SGTC_1109 tnp00067 928.257 nM -0.0943549313295082 0.476207014976003 no 1774 0.462413607805513 2592 676295 SGTC_411 enrofloxacin 100 µM -0.0945011248224197 0.476154069852602 no 1775 0.462355544483267 2667 71188 A bacterial gyrase inhibitor. SGTC_2003 4023581 200 µM -0.0945577993187971 0.476133544851131 no 1776 0.462333035423888 2658 16641307 SGTC_1170 0310-0127 64.8 µM -0.0946246575415875 0.476109331834792 no 1777 0.462306481911933 2645 774975 SGTC_2967 9089538 49.85 µM -0.0950643257874557 0.475950106136309 no 1778 0.462131866802711 2625 728216 SGTC_1459 k035-0031 35.7 µM -0.0953260976764177 0.475855307362307 no 1779 0.462027907045797 2560 3877128 YMR208W ERG12 SGTC_1452 4194-0072 190 µM -0.096062516566494 0.475588625997912 no 1780 0.461735460516204 2696 1343545 SGTC_2443 5493264 126.67 µM -0.0964662785937255 0.475442415196704 no 1781 0.46157512738739 2666 5340055 SGTC_2197 6588183 93.1375 µM -0.0973913046355817 0.475107456128575 no 1782 0.461207824899364 2588 884136 SGTC_803 4488-1585 147 µM -0.0980997328320228 0.474850940695348 no 1783 0.460926549836774 2600 747204 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0988752642215774 0.474570139760143 no 1784 0.460618654470111 2876 5282309 SGTC_446 go6976 132 µM -0.0993540557801042 0.474396787353019 no 1785 0.460428580190235 2628 3501 A protein kinase C inhibitor. SGTC_2929 9013348 24.6 µM -0.0994371868469266 0.474366689214796 no 1786 0.460395579113068 2663 2995952 SGTC_3005 9076496 71.4286 µM -0.100104971869517 0.474124918668461 no 1787 0.460130494090731 2603 21368410 SGTC_304 1310-0298 97 µM -0.101365315054501 0.473668639382286 no 1788 0.459630234598324 2594 1550234 SGTC_2852 9023854 51.95 µM -0.102081996002543 0.473409196313658 no 1789 0.459345795730589 2698 19798528 SGTC_2891 9063876 19.48 µM -0.10255133509166 0.473239298678448 no 1790 0.459159534040773 2601 6472478 SGTC_2626 ethyl orsellinate 100 µM -0.102587499666328 0.473226207544051 no 1791 0.459145182156189 2601 75653 A natural product. SGTC_2754 granisetron 64.02 µM -0.102823735159025 0.473140693892571 no 1792 0.459051433587213 2674 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3071 9117417 49.47 µM -0.102895243627081 0.47311480915978 no 1793 0.459023056350308 2668 45595590 YGL055W OLE1 SGTC_2353 9059630 146.67 µM -0.103862619317771 0.472764648388763 no 1794 0.458639186041502 2675 4779114 SGTC_2872 9044037 25.97 µM -0.10406948429901 0.472689772238227 no 1795 0.45855710366693 2575 6465195 SGTC_2176 5809774 33.9695 µM -0.104327030390136 0.472596553073132 no 1796 0.458454913902093 2667 2870539 SGTC_3293 9120939 62.045 µM -0.104455770456859 0.472549955989655 no 1797 0.458403833133966 2676 934087 SGTC_309 k408-0051 1.48 µM -0.104619191390115 0.472490806811081 no 1798 0.458338992873886 2612 3640463 SGTC_3351 9150312 21.596 µM -0.104785880933972 0.472430475204434 no 1799 0.458272856874505 2579 4904905 SGTC_1940 st075990 51.1 µM -0.105025874719244 0.472343612974954 no 1800 0.45817763860108 2844 1084979 SGTC_1477 0139-0234 16 µM -0.105989389434103 0.471994896242315 no 1801 0.457795385384984 2579 620880 SGTC_3205 9113483 49.47 µM -0.106962180541637 0.471642843961877 no 1802 0.457409491565918 2736 17018033 SGTC_1963 st076565 50.3 µM -0.108293088223617 0.471161225542139 no 1803 0.456881602586101 2604 4914280 SGTC_1026 k007-1105 30.6 µM -0.10838977306657 0.471126239625178 no 1804 0.456843256625946 2597 7066794 SGTC_1739 st037196 92.5 µM -0.109256155469489 0.470812744590527 no 1805 0.45649966060759 2642 612214 SGTC_690 glyoxal 20.3 µM -0.109477196453198 0.470732765186143 no 1806 0.45641200381888 2599 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_467 ro 31-8220 72.8 µM -0.110791556840476 0.470257213792943 no 1807 0.455890820398639 2690 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1398 3558-0053 112 µM -0.111517486794876 0.46999458174564 no 1808 0.455602999815764 2611 4532369 SGTC_2464 5717415 7.67 µM -0.112709274257256 0.469563436848309 no 1809 0.455130524156101 2611 5285744 SGTC_2591 skatole 100 µM -0.113950680652349 0.469114379595906 no 1810 0.454638444912873 2695 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_447 ml7 120 µM -0.114755772794796 0.468823172429314 no 1811 0.454319352791303 2649 4216 Selective myosin light chain kinase inhibitor. SGTC_1826 st055655 41.6 µM -0.115271553380375 0.468636619926852 no 1812 0.454114942575242 2655 676168 SGTC_526 4469-0568 170 µM -0.115881070630414 0.468416172722857 no 1813 0.453873399032017 2594 2901964 SGTC_1274 0865-0114 173 µM -0.119019021577013 0.46728140877843 no 1814 0.452630142928855 2672 870624 SGTC_2286 7945697 125 µM -0.119375116846406 0.467152652175245 no 1815 0.452489087095021 2687 1245733 SGTC_2845 9003024 42.97 µM -0.120442916442485 0.466766578828724 no 1816 0.452066148208785 2820 2990173 SGTC_1375 2910-0797 186 µM -0.120481060238516 0.46675278814391 no 1817 0.45205104104513 2699 742508 SGTC_771 0250-0039 27.3 µM -0.120946516175557 0.466584508267189 no 1818 0.451866698998029 2606 3005115 SGTC_333 3486-0131 40.1 µM -0.122589188975335 0.465990668034535 no 1819 0.45121620790768 2764 6744690 SGTC_697 0508-1955 564 µM -0.123113255532214 0.465801229370571 no 1820 0.451008707368667 2642 6243113 SGTC_2398 5228213 48.84 µM -0.124156092755658 0.465424289485207 no 1821 0.450595843041666 2671 80771 YMR134W ERG29 SGTC_982 1491-0518 27.5 µM -0.125214201450904 0.465041861339288 no 1822 0.45017698729878 2679 3091256 SGTC_362 0310-0100 9.03 µM -0.126340796204405 0.46463471603838 no 1823 0.449731082133878 2726 790235 SGTC_20 0481-0013 4.944 µM -0.126564330436061 0.46455393635463 no 1824 0.449642615018664 2626 182045 SGTC_1828 st055811 49 µM -0.128167761889104 0.463974539332501 no 1825 0.449008105952051 2663 5877589 SGTC_3 0833-0587 95.581 µM -0.129234906109976 0.463588970984927 no 1826 0.448585888356488 2623 5382644 SGTC_2001 4023502 57.655 µM -0.129421517776637 0.463521550094116 no 1827 0.448512061071326 2726 108941 YCR052W RSC6 SGTC_1437 4092-1038 11.6 µM -0.129906561721152 0.463346313572149 no 1828 0.44832017639074 2648 3977136 SGTC_1461 k072-0203 53.8 µM -0.130679088435161 0.463067230064099 no 1829 0.448014587739186 2619 5418714 SGTC_157 1348-1695 65.819 µM -0.131623776134717 0.462725976283615 no 1830 0.44764093925359 2645 5380510 SGTC_1142 3253-1408 9.78 µM -0.131918305337222 0.462619587774611 no 1831 0.447524454800126 2613 256655 SGTC_1628 st004252 77.7 µM -0.134189614001295 0.461799246299666 no 1832 0.446626319229957 2785 692968 SGTC_2723 salbutamol 83.58 µM -0.135330324547774 0.461387310458046 no 1833 0.446175355045596 2734 9884233 β2-adrenoceptor agonist SGTC_2324 6149169 200 µM -0.135495496052625 0.461327666792459 no 1834 0.446110062524717 2723 2888231 SGTC_2935 9038016 29.96 µM -0.137491441087537 0.460606997351143 no 1835 0.445321178760753 2685 6463195 SGTC_1272 0839-0021 27 µM -0.137744460994684 0.460515649459038 no 1836 0.445221189750352 2728 5027250 SGTC_2914 7968218 45.32 µM -0.138567762622382 0.460218426944107 no 1837 0.444895859599715 2741 2977111 SGTC_1761 st044296 37 µM -0.140365175951471 0.459569614989577 no 1838 0.444185735489604 2638 1826700 SGTC_3073 9114972 49.47 µM -0.141364775839759 0.459208836077756 no 1839 0.443790889794815 2724 41905075 SGTC_1677 st019204 53.9 µM -0.141566897350448 0.459135889784049 no 1840 0.443711057810646 2779 3945625 SGTC_1181 1222-0449 220 µM -0.142349289694794 0.458853534900248 no 1841 0.443402057672033 2814 658318 SGTC_3004 9076122 71.4286 µM -0.142964027881796 0.458631698703532 no 1842 0.443159295449742 2772 44782551 SGTC_1932 st074806 40.9 µM -0.144709391258648 0.45800193227912 no 1843 0.442470162030021 2901 17251235 SGTC_3089 9117425 49.47 µM -0.144795993481991 0.457970686978209 no 1844 0.442435972813619 2728 9401657 SGTC_2437 5741531 144.16 µM -0.146498227067984 0.457356589424711 no 1845 0.441764044707379 2799 2262990 SGTC_2546 rhodinyl acetate 100 µM -0.146806302667154 0.457245458951085 no 1846 0.44164245489038 2672 6708682 SGTC_2344 7990960 76.95 µM -0.147852103757223 0.456868237669645 no 1847 0.441229744159018 2708 140813 SGTC_3340 9146634 11.102 µM -0.148800575525084 0.456526156747649 no 1848 0.440855498246099 2728 4907387 SGTC_1066 ketoconazole 628 nM -0.148901904564249 0.456489612772474 no 1849 0.440815519172559 2826 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2995 9067767 71.4286 µM -0.148962006279042 0.456467937466213 no 1850 0.440791806503223 2750 11673567 SGTC_897 1000-0139 31.4 µM -0.15056383886223 0.455890294530708 no 1851 0.44015989426996 2796 6151020 SGTC_3028 9087778 49.47 µM -0.151637067650219 0.455503325497072 no 1852 0.439736597850421 2681 17217395 SGTC_736 0958-0254 92.6 µM -0.152563425710703 0.455169346876082 no 1853 0.439371284666564 2776 6812352 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.153402675967477 0.454866800461586 no 1854 0.439040367373906 2712 2374 Ca(2+)-ATPase inhibitor. SGTC_663 1486-0733 13.9 µM -0.153510687271586 0.454827864709271 no 1855 0.438997781488109 2678 722445 YPR165W RHO1 SGTC_716 1683-5115 658 µM -0.155497163827828 0.45411186039991 no 1856 0.438214694842447 2661 723597 SGTC_2975 9084847 53.72 µM -0.156404823501372 0.453784753628979 no 1857 0.437856967681149 2789 27211724 SGTC_2102 5377816 72.7585 µM -0.157508692943786 0.453386978101282 no 1858 0.437421978714623 2851 1379702 SGTC_2669 eugenol 100 µM -0.157751477292152 0.453299497862279 no 1859 0.437326317643386 2683 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3051 9093778 49.47 µM -0.158861704416907 0.452899488929483 no 1860 0.436888916457856 2674 17217378 SGTC_1934 st074720 32.6 µM -0.158870240438671 0.452896413630824 no 1861 0.436885553781027 2690 17250992 SGTC_3156 9099931 49.47 µM -0.159726897607774 0.452587797533711 no 1862 0.436548105849162 2693 18111053 SGTC_1267 0828-0272 9.49 µM -0.160195930584175 0.452418837595109 no 1863 0.436363367460489 2809 745334 SGTC_1185 1319-0113 81.3 µM -0.160316006814237 0.452375583870231 no 1864 0.436316075170963 2793 4672763 SGTC_1558 st069300 45.6 µM -0.161297285853389 0.452022129863435 no 1865 0.435929630423515 2718 24208000 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.162072569759833 0.451742901610124 no 1866 0.435624353372697 2663 5355888 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.162775201084484 0.451489860715293 no 1867 0.435347717248868 2761 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1837 st055472 66.5 µM -0.163115114113659 0.45136745380237 no 1868 0.435213899915217 2860 676091 SGTC_600 1495-0418 41.6 µM -0.164366599244431 0.450916818370787 no 1869 0.434721277938263 2705 5377768 SGTC_1475 4092-1048 11.7 µM -0.164781397766914 0.450767471427511 no 1870 0.434558023154067 2756 2881759 SGTC_951 1171-0579 82.7 µM -0.164784734209816 0.450766270179647 no 1871 0.434556710055086 2654 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1357 1503-1303 39.5 µM -0.166239120811525 0.450242678117306 no 1872 0.43398438689723 2723 292895 SGTC_2804 7954240 19.48 µM -0.166630460301902 0.450101807180604 no 1873 0.433830412453948 2852 828705 SGTC_1909 st060837 51.5 µM -0.167021082334205 0.449961200777792 no 1874 0.433676730310662 2757 678937 SGTC_270 tamoxifen 5.46 µM -0.167964068519101 0.449621793985654 no 1875 0.433305773299974 2861 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1778 st046819 58.9 µM -0.16871869929513 0.44935020804502 no 1876 0.433008954864282 2711 671715 SGTC_751 0833-0568 350 µM -0.16961444156701 0.449027867944304 no 1877 0.432656682197014 2778 6954252 SGTC_2011 4012611 177 µM -0.169975050587749 0.448898109357261 no 1878 0.432514878929067 2707 2049887 SGTC_2041 5107442 45.335 µM -0.17045306623105 0.448726112562801 no 1879 0.432326920934777 2819 793005 SGTC_1270 0831-1170 17.3 µM -0.173555267136959 0.447610132376666 no 1880 0.43110749501526 2701 6764716 SGTC_2074 5212007 75.395 µM -0.173637134339187 0.447580687192556 no 1881 0.431075323157251 2728 758611 SGTC_2962 9082311 13.18 µM -0.174515791227371 0.447264678810618 no 1882 0.430730060792252 2715 16459453 SGTC_2611 pyromycin 23.93 µM -0.174830393503163 0.447151540433721 no 1883 0.430606452782998 2760 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_561 1550-0330 72.9 µM -0.17792304653305 0.446039580031399 no 1884 0.429391705551476 2740 6812934 SGTC_1362 1611-0397 101 µM -0.17970616586087 0.445398653459153 no 1885 0.42869162629807 2747 27816 SGTC_2072 5231554 129 µM -0.180817807797598 0.444999155630604 no 1886 0.428255292453614 2832 789545 SGTC_300 r073-0011 5.04 µM -0.180971296768652 0.444943999702845 no 1887 0.428195052924842 2740 2735780 SGTC_2909 7941780 10.49 µM -0.182708176298273 0.444319930350384 no 1888 0.42751349999911 2761 1243215 SGTC_797 k781-0471 270 µM -0.183680101051917 0.443970773134625 no 1889 0.427132210178468 2750 23738129 SGTC_3162 9099653 49.47 µM -0.183900796569288 0.443891495851597 no 1890 0.427045639947572 2743 25237511 SGTC_1460 k062-0059 9.15 µM -0.184451578988211 0.443693655989149 no 1891 0.42682960485336 2648 1373085 SGTC_1797 st048695 56.8 µM -0.185333524383338 0.443376892341822 no 1892 0.426483722412348 2868 592262 YIL048W NEO1 SGTC_2899 9053889 58.44 µM -0.186143199555398 0.443086117456282 no 1893 0.426166232763434 2763 6470052 SGTC_1278 0874-0585 172 µM -0.186731603680486 0.442874825834575 no 1894 0.425935537876907 2802 766306 SGTC_1206 3978-0017 132 µM -0.187273125397668 0.442680383696414 no 1895 0.42572324651408 3020 3873677 SGTC_1701 st028638 40.4 µM -0.187920039740063 0.442448116731263 no 1896 0.425469666577541 2831 3490878 SGTC_2424 5537928 59.2 µM -0.189365876958454 0.441929077555102 no 1897 0.424903033410535 2762 5382802 SGTC_87 0100-0052 35.5 µM -0.189870372059723 0.441747992946218 no 1898 0.424705354891549 2770 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2873 9040596 71.43 µM -0.189875253823046 0.441746240734498 no 1899 0.424703442141322 2843 6463863 SGTC_2116 5511452 16.8835 µM -0.191668292065054 0.441102742749111 no 1900 0.424001022359635 2862 870744 SGTC_2777 climbazole 1.536 µM -0.192054337786848 0.440964216267593 no 1901 0.423849821085365 2786 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2077 5212015 200 µM -0.19262018091667 0.440761185349943 no 1902 0.423628219407314 2701 780900 SGTC_1451 4152-0210 104 µM -0.192647329154922 0.440751444645898 no 1903 0.423617587923821 2908 659563 SGTC_1525 8-methoxypsoralen 92.5 µM -0.19374585708924 0.440357326352744 no 1904 0.423187441669319 3003 4114 Related to psoralen; DNA damaging agent. SGTC_544 k015-0020 52.4 µM -0.193819053967358 0.440331067642232 no 1905 0.423158783503628 2776 3008304 SGTC_2594 a-mangostin 100 µM -0.194815026467591 0.439973797743059 no 1906 0.422768879128157 2906 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_717 1532-0246 73.2 µM -0.195150685931534 0.43985340278169 no 1907 0.422637491828013 2833 9561992 SGTC_3118 9124250 49.47 µM -0.196932159817964 0.439214513768037 no 1908 0.421940313278435 2820 1504786 SGTC_107 0358-0022 2.6945 µM -0.198232022386985 0.438748444561477 no 1909 0.421431767173693 2817 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2499 avocadenofuran 51.48 µM -0.198660635039833 0.438594782931893 no 1910 0.421264109441868 2738 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1790 st045711 43.5 µM -0.198833613041435 0.438532771326737 no 1911 0.421196450759829 2894 585119 SGTC_2052 5265182 7.135 µM -0.199060288131252 0.438451511913064 no 1912 0.42110779250104 2893 1239884 SGTC_1389 3405-0187 19 µM -0.200153345456894 0.438059704733002 no 1913 0.42068032686008 2809 799890 SGTC_1493 4348-0038 111 µM -0.201011476073674 0.437752149721074 no 1914 0.420344800303838 2793 800424 SGTC_3032 9089427 49.47 µM -0.202019681388072 0.437390855816392 no 1915 0.41995066893596 2862 17173707 SGTC_55 0767-0285 6.563 µM -0.202783070884248 0.437117327226753 no 1916 0.419652295254396 2881 3116166 SGTC_1380 2291-0730 164 µM -0.203711536018382 0.436784691228855 no 1917 0.419289463395427 2855 2999191 SGTC_698 k064-0052 127 µM -0.204880928203391 0.436365803265204 no 1918 0.418832578115954 2740 5088751 SGTC_1863 st057641 20.1 µM -0.205026740111991 0.436313576976622 no 1919 0.418775616597628 2751 3921635 SGTC_1693 xanthone 101.9 µM -0.206279972309577 0.435864745478102 no 1920 0.418286110947916 2816 7020 An insecticide. SGTC_363 0455-0021 3.06 µM -0.207355751465262 0.435479532710979 no 1921 0.417866018382581 2765 4597466 SGTC_1920 st075728 45.7 µM -0.209553462765984 0.434692771459663 no 1922 0.417008102210939 2968 3400306 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.210650980673243 0.434299966334445 no 1923 0.416579813978902 2769 15053 SGTC_451 chloral hydrate 100 µM -0.211830820678989 0.433877770216035 no 1924 0.416119511345327 2892 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2190 6049624 200 µM -0.215108117500124 0.432705413489027 no 1925 0.414841512598665 2773 2265554 SGTC_3168 9103419 49.47 µM -0.215319720561379 0.432629738945525 no 1926 0.414759027709362 2786 16649256 SGTC_1222 0366-0074 1.18 µM -0.21642311078091 0.432235179122307 no 1927 0.414328976659934 2932 286520 SGTC_2488 5268135 45.7 µM -0.216592400312982 0.432174649075787 no 1928 0.414263004415273 2911 1270356 YLR208W SEC13 SGTC_413 propylparaben 100 µM -0.217803334809208 0.431741721844289 no 1929 0.413791173069627 2782 7175 A pharmaceutical preservative. SGTC_381 3461-2219 42.7 µM -0.219518701724913 0.431128592878877 no 1930 0.413123006624846 2920 2883159 SGTC_3278 9139605 49.47 µM -0.219948093809445 0.430975139831601 no 1931 0.412955789932892 3001 7958859 SGTC_2878 9043973 25.97 µM -0.222758714323483 0.429970958889113 no 1932 0.411861650912219 2976 6465167 SGTC_1197 1601-0112 267 µM -0.223442429335925 0.429726748822391 no 1933 0.411595592548275 2804 7350313 SGTC_2182 6325192 200 µM -0.223976461568159 0.429536021309238 no 1934 0.411387809459187 2784 736248 SGTC_2823 7987624 58.44 µM -0.22872177584182 0.42784197832714 no 1935 0.409542584355794 3007 2239440 SGTC_3129 9127257 49.47 µM -0.228785813636181 0.427819126316517 no 1936 0.409517696729019 2846 837894 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.229797896086665 0.427457994939306 no 1937 0.409124409830054 3022 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2471 5466956 24.79 µM -0.230531125636197 0.427196401831876 no 1938 0.408839539979327 2829 724419 SGTC_2717 st081029 62.2815 µM -0.231069325075214 0.427004409662288 no 1939 0.408630472664773 2909 5292846 SGTC_2734 clemastine 41.6 µM -0.231392487250161 0.426889136154326 no 1940 0.408504950559144 2800 26987 Clemastine is a selective histamine H1 antagonist. SGTC_220 paclitaxel 373.376 µM -0.232636300182672 0.426445520421868 no 1941 0.408021918535712 2923 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2225 6654152 15.4 µM -0.233740377593677 0.426051820399441 no 1942 0.407593269553332 2871 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1360 1598-0022 39.8 µM -0.234281616971821 0.425858848184688 no 1943 0.407383178182291 2935 761525 SGTC_1817 st052116 64.4 µM -0.234732572058676 0.425698079275655 no 1944 0.407208152552534 2979 4361398 SGTC_77 0828-0286 12.516 µM -0.23536433396799 0.425472872140798 no 1945 0.406962982966043 2780 745345 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.236284279149573 0.425144978458377 no 1946 0.406606042514758 2766 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2807 7945238 51.95 µM -0.236304680748544 0.42513770735521 no 1947 0.406598127534454 2932 17148797 SGTC_906 1165-0455 526 µM -0.23725917175857 0.424797556515643 no 1948 0.40622786703323 2823 3252859 SGTC_2024 5144227 134 µM -0.237590913035442 0.424679347365025 no 1949 0.406099199538606 2982 3475211 SGTC_855 0428-0020 25 µM -0.237624988059462 0.424667205817593 no 1950 0.406085983946137 2845 6812414 SGTC_1972 st070201 17.4 µM -0.237644403187673 0.42466028788818 no 1951 0.406078454067613 2961 2829099 SGTC_617 3770-0098 35 µM -0.237877971377011 0.424577065521327 no 1952 0.405987870725029 2841 5962639 SGTC_2858 9025781 8.96 µM -0.238186980828481 0.424466967947026 no 1953 0.405868037186969 2933 4894980 YPL153C RAD53 SGTC_2432 5630864 12.22 µM -0.238247379614839 0.424445449035022 no 1954 0.405844615631658 2977 5714970 SGTC_487 nimodipine 119 µM -0.239660313032594 0.423942112748713 no 1955 0.405296801979447 2909 4497 L-type voltage-gated calcium channels inhibitor SGTC_3176 9106582 49.47 µM -0.240099548397422 0.423785666991155 no 1956 0.405126542150363 2891 17018027 SGTC_2109 5483026 200 µM -0.240156918265544 0.423765234020888 no 1957 0.405104305320828 2871 759335 SGTC_1332 1480-0653 17.5 µM -0.240364363243755 0.423691351701579 no 1958 0.405023901233153 2948 5749438 SGTC_1219 1469-0211 33.1 µM -0.240377519778111 0.423686666042176 no 1959 0.405018801996175 2939 6822282 SGTC_235 0330-0087 5 mM -0.241168396065334 0.42340501771917 no 1960 0.40471230216987 2855 46494818 YHR062C RPP1 SGTC_667 1498-1044 59 µM -0.241757271749422 0.42319533163222 no 1961 0.404484124540501 2875 6739982 SGTC_1298 1079-1278 263 µM -0.242712329015839 0.422855302358562 no 1962 0.404114127915018 2851 2840950 SGTC_2762 leflunomide 42.06 µM -0.243446483766858 0.422593960113636 no 1963 0.403829768926046 2832 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3131 9127911 49.47 µM -0.243894390327524 0.42243453238178 no 1964 0.403656306942789 3081 45595681 SGTC_1245 0418-0076 17.2 µM -0.244025449742656 0.422387885533172 no 1965 0.403605554791049 3021 6790114 SGTC_2826 7992541 19.48 µM -0.245011905646185 0.422036819755921 no 1966 0.403223606452009 2781 2985066 SGTC_935 2996-0153 430 µM -0.245701340484959 0.421791496352487 no 1967 0.402956717223006 3021 23738523 SGTC_555 4296-0685 37 µM -0.24648904725347 0.421511241740812 no 1968 0.402651840984244 2866 2908540 YHR072W ERG7 SGTC_310 1273-0058 1.06 µM -0.247615232637131 0.421110630442336 no 1969 0.402216061880781 2950 2734232 SGTC_2300 7976697 71.57 µM -0.248205955386785 0.420900528741046 no 1970 0.401987529386201 2855 2236109 SGTC_640 3381-0960 37.1 µM -0.251614982557679 0.419688485765429 no 1971 0.400669338369191 2901 1745025 SGTC_2945 9067681 61.76 µM -0.252954559062825 0.419212421493728 no 1972 0.400151664009128 2786 16456930 SGTC_912 3474-0017 2.18 µM -0.253386437288733 0.419058963986389 no 1973 0.399984803619424 3030 3360550 SGTC_2426 5582046 32.21 µM -0.253398247718246 0.419054767608082 no 1974 0.399980240800465 3019 2251934 SGTC_1242 0402-0103 60.1 µM -0.255781146949402 0.418208285734325 no 1975 0.399059916159696 2835 432868 SGTC_2524 avocatin b 10.57 µM -0.256427282414666 0.417978822892558 no 1976 0.398810461806208 2970 6710748 SGTC_1441 4106-0040 13 µM -0.25678450973368 0.417851972317235 no 1977 0.398672564328216 2858 2904180 SGTC_1810 st050138 53 µM -0.258581802634458 0.417213887790228 no 1978 0.397978962608783 2951 3444541 SGTC_2676 harmalol 100 µM -0.259299578533611 0.416959119970514 no 1979 0.397702052286277 2952 5459187 A monoamine oxidase inhibitor SGTC_1002 4049-0206 172 µM -0.259904269869878 0.416744517511256 no 1980 0.397468808776791 2856 4662749 SGTC_2627 acetyl isogambogic acid 100 µM -0.260218133596827 0.416633138346369 no 1981 0.397347758684023 2956 6857789 A caspase activator and apoptosis inducer. SGTC_2513 baicalein 25.65 µM -0.260935456269868 0.416378610973394 no 1982 0.397071140796814 2908 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1561 5-methoxyflavone 52.9 µM -0.263279129243041 0.415547251196174 no 1983 0.396167722422942 2853 94525 SGTC_112 phenothiazine 287.218 µM -0.264394343202996 0.415151789202079 no 1984 0.3957380349812 2974 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_282 k297-0036 65.7 µM -0.266293309945933 0.414478601446169 no 1985 0.395006662520832 3022 5061378 SGTC_2886 9058944 51.95 µM -0.266641676876903 0.414355131829301 no 1986 0.394872531736935 2912 4949929 SGTC_582 0987-0078 156 µM -0.267085483363018 0.414197848398919 no 1987 0.394701672165521 2933 1625765 SGTC_2651 TUB2.036 5 µM -0.267193124097718 0.414159702980138 no 1988 0.394660234970253 2998 15992207 YFL037W TUB2 SGTC_2487 5918373 44.05 µM -0.268071192231518 0.413848565956568 no 1989 0.394322259897777 2922 2876279 SGTC_2332 7982454 138.89 µM -0.268112588436873 0.413833898847074 no 1990 0.394306328146487 2950 2981748 SGTC_2993 9054257 71.4286 µM -0.270042854292634 0.413150119232905 no 1991 0.39356364245108 2862 6470217 YGL055W OLE1 SGTC_3335 9143315 29.6265 µM -0.27059498423827 0.412954580432106 no 1992 0.393351276977307 2922 4899691 SGTC_1411 3909-8223 150 µM -0.270664590832261 0.412929930538981 no 1993 0.393324506477447 3005 X1411 SGTC_1050 3232-1156 69.3 µM -0.271342437950088 0.412689901432191 no 1994 0.393063834775341 2913 700529 SGTC_3296 9122258 64.045 µM -0.271511116570537 0.412630176544967 no 1995 0.392998975464965 2977 4730474 SGTC_3285 9112818 20.8695 µM -0.271884390121003 0.412498016894933 no 1996 0.392855457078316 2865 17017947 YPR165W RHO1 SGTC_1741 st038134 10.228 µM -0.272195447013522 0.412387892987865 no 1997 0.392735871239015 3123 1272587 SGTC_2386 9075165 157.42 µM -0.272739980163104 0.412195127764856 no 1998 0.392526549822401 2873 16452277 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.273001378402348 0.412102600075566 no 1999 0.392426077998836 3020 521171 SGTC_2153 5569715 200 µM -0.273639143887361 0.411876869386799 no 2000 0.392180974612652 2894 2054701 SGTC_1182 1222-0449 220 µM -0.276533103213897 0.410852948943652 no 2001 0.391069318907454 2964 658318 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.277788147439681 0.410409086310874 no 2002 0.390587495105694 2850 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2285 7945142 200 µM -0.278037758713915 0.410320821713879 no 2003 0.390491686887679 3005 2970608 SGTC_2677 mitomycin C 100 µM -0.282015340192948 0.408914932046523 no 2004 0.388965873874982 2928 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1350 1495-0454 146 µM -0.282829279905205 0.408627386040643 no 2005 0.388653854102082 3067 1069057 SGTC_1011 4112-3381 17.4 µM -0.283326691595346 0.408451686238175 no 2006 0.388463209129154 3066 2877139 SGTC_2567 aureobasidin a 60 nM -0.283513467709944 0.408385716410078 no 2007 0.38839162963445 3152 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3334 9142812 21.919 µM -0.283584878495111 0.408360494613876 no 2008 0.3883642633897 3019 45283678 SGTC_1509 1326-1131 80 µM -0.284550417380313 0.408019510254562 no 2009 0.387994301280614 3015 768313 SGTC_2435 5706476 10.6 µM -0.284776417008431 0.407939707528846 no 2010 0.387907720471428 3063 5725375 SGTC_247 mechlorethamine 29.705 µM -0.285924950090313 0.407534208115027 no 2011 0.387467801859838 2894 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1764 st044502 93.5 µM -0.288223965317163 0.406722819147356 no 2012 0.386587652570046 3044 8407 SGTC_3330 9141424 71.43 µM -0.289296505912129 0.406344425257737 no 2013 0.386177242969431 3048 27261020 SGTC_1481 3346-2004 36 µM -0.290165368506994 0.406037953362444 no 2014 0.385844864454709 2939 2770522 SGTC_1785 bathophenanthroline 24 µM -0.290463869493076 0.405932677076528 no 2015 0.385730693901556 2941 72812 An iron chelator. SGTC_769 0302-0231 76 µM -0.291274301473282 0.405646885649058 no 2016 0.385420770106858 3010 571869 YER009W NTF2 SGTC_165 k038-0023 64.381 µM -0.291969853239507 0.405401645772119 no 2017 0.385154836901606 2933 46368543 SGTC_3128 9127691 49.47 µM -0.292434527633409 0.40523783006527 no 2018 0.384977206085314 3061 41316314 SGTC_1070 indatraline 8.81 µM -0.293286339049368 0.404937576702861 no 2019 0.384651647320633 2936 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2264 7948757 110.76 µM -0.294504378974595 0.404508329411873 no 2020 0.384186258887779 2869 2971411 SGTC_3211 9128781 49.47 µM -0.294864903679472 0.404381299556039 no 2021 0.384048541671303 3036 17194361 SGTC_463 ikarugamyin 104 µM -0.295036451254541 0.404320858793528 no 2022 0.383983017169345 2961 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2467 5474540 200 µM -0.296386981399773 0.403845111052396 no 2023 0.383467283141657 2918 5413519 SGTC_397 arbidol 50 µM -0.296469426026291 0.403816073096905 no 2024 0.38343580625559 3081 131410 A RNA synthesis inhibitor. SGTC_351 caspofungin 25 nM -0.29660899261364 0.403766917331361 no 2025 0.383382522285841 2958 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2602 kawain 100 µM -0.297618259914916 0.403411495678943 no 2026 0.382997268201115 2934 5369129 SGTC_2702 st077768 96.8 µM -0.303077678676241 0.401490306964985 no 2027 0.380915332230922 3024 6484119 SGTC_219 mitoxanthrone 164.414 µM -0.303749846774882 0.401253932178551 no 2028 0.38065923941268 2984 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2317 5986382 200 µM -0.304756240780147 0.400900091012784 no 2029 0.380275905900022 3013 877883 SGTC_2383 9036125 200 µM -0.305771511879711 0.400543211083521 no 2030 0.37988931023264 2941 79580 SGTC_1258 0671-0043 57.1 µM -0.308068483430893 0.399736104901887 no 2031 0.379015111141664 2988 4298767 SGTC_174 3553-0389 74.3 µM -0.30815976609553 0.399704038969729 no 2032 0.378980382831591 3092 738071 SGTC_2948 9070189 9.45 µM -0.308244616546428 0.399674233163328 no 2033 0.378948102520621 3086 6473636 YDL196W YDL196W SGTC_1341 1486-1360 280 µM -0.308470803849275 0.399594782170618 no 2034 0.37886205646737 2927 3976547 SGTC_65 0798-0905 34.986 µM -0.310624315746309 0.398838544057549 no 2035 0.378043119862621 3350 3602145 SGTC_409 arachidonic acid 100 µM -0.311000822915561 0.398706366804898 no 2036 0.377899998018576 2971 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2463 5473429 200 µM -0.311421141609308 0.39855882272732 no 2037 0.377740241876498 3009 5399405 SGTC_3276 9139060 49.47 µM -0.313739202647048 0.397745376934847 no 2038 0.376859561786621 2926 4870619 SGTC_433 pimozide 108 µM -0.313916090448552 0.39768332229663 no 2039 0.376792384633156 2899 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_996 3970-0799 1.8 µM -0.315519558950898 0.397120922097228 no 2040 0.376183601505806 3020 6615648 YGL040C HEM2 SGTC_1401 3807-4679 7.6 µM -0.316716162030333 0.396701365066793 no 2041 0.375729492070159 2965 3291456 SGTC_2302 7771753 200 µM -0.318540974743765 0.396061773379275 no 2042 0.375037309309122 3039 2203047 SGTC_1983 st071813 46.9 µM -0.319000201885327 0.39590085955019 no 2043 0.374863179845848 3037 11838595 SGTC_2439 5492030 7.2 µM -0.319275899199791 0.395804263347427 no 2044 0.374758653359884 3074 5722370 SGTC_278 4092-0821 23.9 µM -0.319955907687133 0.395566035809402 no 2045 0.374500877727122 3037 877900 SGTC_596 1155-0152 116 µM -0.320537602888886 0.395362281346124 no 2046 0.374280414907048 2996 280313 SGTC_3331 9141060 1.957 µM -0.321692626248424 0.394957788032937 no 2047 0.373842782280612 2977 4906567 YPR165W RHO1 SGTC_1438 4092-1045 4 µM -0.322593329405064 0.394642437086547 no 2048 0.373501623114609 2977 1351342 SGTC_1640 st009078 66.4 µM -0.323552953321142 0.394306532963852 no 2049 0.373138255600116 3095 690618 SGTC_1608 st001473 40.5 µM -0.324246367421339 0.394063861089987 no 2050 0.372875760262141 2980 7292267 SGTC_1449 4112-4002 201 µM -0.324278906314865 0.39405247456883 no 2051 0.372863443951705 3010 2059539 SGTC_2616 abietic acid 100 µM -0.324912457375565 0.393830790480715 no 2052 0.37262366418317 3137 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_839 0122-0028 230 µM -0.325545219960061 0.393609416621996 no 2053 0.372384232089975 2997 759448 SGTC_1515 3460-0031 42.1 µM -0.326162783347931 0.39339339340018 no 2054 0.372150598799113 3008 2876596 SGTC_781 4335-2806 94.4 µM -0.327498026735866 0.392926438493836 no 2055 0.371645617594047 3124 845254 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.329526923027695 0.392217197684278 no 2056 0.370878723804752 3032 1241132 A phosphatase inhibitor. SGTC_2414 st077232 92.9 µM -0.329893634322543 0.392089044624187 no 2057 0.370740166789443 2939 729801 SGTC_424 splitomicin 100 mM -0.330135927906039 0.392004377721215 no 2058 0.370648628556391 3074 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2418 pentamidine 31.67 µM -0.330814668066744 0.391767226464607 no 2059 0.370392240315061 3076 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2954 9074818 52.69 µM -0.331630598891829 0.391482194132778 no 2060 0.370084105683222 3158 16648742 SGTC_1042 0350-0096 82 µM -0.331987747052907 0.391357448479017 no 2061 0.369949255620981 2983 3122515 SGTC_632 0781-2353 4.65 µM -0.332634657054063 0.391131522500752 no 2062 0.369705039575254 3084 6811515 YHR007C ERG11 SGTC_1043 0916-0009 19.3 µM -0.332976370799822 0.391012197672825 no 2063 0.369576059866786 3175 3101130 SGTC_2162 5663267 200 µM -0.332976612932032 0.391012113125035 no 2064 0.369575968479287 3143 6456493 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.333362924603972 0.390877227275604 no 2065 0.369430172987615 3032 6708561 SGTC_1562 morin hydrate 59.1 µM -0.3336023993633 0.390793618073938 no 2066 0.369339803729541 3159 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1820 st053765 18.6 µM -0.333768405298788 0.390735662428223 no 2067 0.369277163229427 3060 3690829 SGTC_594 1487-1584 10.8 µM -0.333782218962713 0.390730839940071 no 2068 0.36927195095282 2999 5013332 SGTC_1456 k015-0012 13 µM -0.333802728248418 0.39072367997443 no 2069 0.369264212277668 3196 2989616 SGTC_373 0844-0104 25.9 µM -0.333877421188936 0.390697604348383 no 2070 0.369236029179231 3134 5375804 SGTC_2280 7785178 200 µM -0.334280079241492 0.390557043164079 no 2071 0.369084110579083 2995 2954328 SGTC_2841 9004761 38.96 µM -0.334706508195255 0.390408199549349 no 2072 0.368923245764441 3009 2991039 SGTC_2343 7990716 14.84 µM -0.335499501686205 0.390131450515238 no 2073 0.368624160276599 2963 6456862 SGTC_620 0109-0052 432 µM -0.336773385314527 0.389686990883884 no 2074 0.368143868858408 3157 493037 SGTC_705 1124-0212 310 µM -0.338420798603411 0.38911242020523 no 2075 0.367523051393483 3157 9554485 SGTC_1497 4476-2978 41.3 µM -0.339723298164849 0.388658317094255 no 2076 0.367032457387434 3080 1528379 SGTC_40 0327-0103 19.753 µM -0.34043395382796 0.388410618382601 no 2077 0.366764876280111 3010 409036 SGTC_1271 0832-2808 169 µM -0.341437627603634 0.388060865655283 no 2078 0.366387076208041 3150 3663794 SGTC_2396 5342950 42.78 µM -0.341447859720997 0.388057300510546 no 2079 0.366383225329065 3091 1886677 SGTC_2794 7785382 27.27 µM -0.341667924494385 0.387980626311893 no 2080 0.366300406743819 3092 2205081 SGTC_1301 naphtanilide LB 4.81 µM -0.342333986341408 0.387748585994265 no 2081 0.366049780777587 3129 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1731 st035964 63 µM -0.343366886322546 0.387388827179988 no 2082 0.3656612338876 3024 6739575 SGTC_2213 7173844 200 µM -0.34341317143536 0.387372708347425 no 2083 0.365643825998802 3034 892728 SGTC_2141 5621638 7.665 µM -0.343682288952102 0.387278991775142 no 2084 0.365542616046787 3137 2856238 SGTC_777 1315-0167 517 µM -0.344200907366886 0.387098408387581 no 2085 0.365347599984366 3085 4221767 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.345688419511418 0.386580591019734 no 2086 0.364788444111327 3120 1377 SGTC_3151 9099821 49.47 µM -0.346546475365038 0.386281985229554 no 2087 0.364466031543841 3126 17174189 SGTC_1938 st074717 56.4 µM -0.348131822681174 0.385730457280312 no 2088 0.363870593155314 2949 17250979 SGTC_249 wiskostatin 11.211 µM -0.348189056117251 0.385710550599523 no 2089 0.363849103065385 3114 2775510 A n-wasp and actin depolymerizer. SGTC_2048 5246248 200 µM -0.34855844587902 0.385582078327961 no 2090 0.363710414389663 3142 677046 SGTC_90 0870-0863 4.608 µM -0.349862346176248 0.385128687496675 no 2091 0.363221003337114 2977 1738164 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.350603217468322 0.384871142415777 no 2092 0.362943021198705 3206 165506 SGTC_2145 5634607 200 µM -0.352910330064189 0.384069459151179 no 2093 0.362077833114505 3018 308662 SGTC_2744 captopril 92.04 µM -0.354730884704054 0.383437196457731 no 2094 0.361395605521878 3127 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_925 2064-1272 59.6 µM -0.356637288622079 0.382775451643403 no 2095 0.360681679225432 3050 6815817 SGTC_882 0843-0131 351 µM -0.358164383258749 0.382245618084618 no 2096 0.360110149793058 3163 5425421 SGTC_2642 cholecalciferol 100 µM -0.359432749056354 0.381805719372443 no 2097 0.359635689572467 3130 9821465 A vitamin D precursor, similar to steriods. SGTC_1248 0469-0687 58.6 µM -0.36043046057426 0.381459797033851 no 2098 0.35926262548359 3138 4017482 SGTC_1120 ficusin 1.78878 µM -0.361769515789174 0.380995674277849 no 2099 0.358762137103507 3172 6199 A DNA cross-linker. SGTC_2715 st079500 56.4 µM -0.361864012273542 0.380962927815204 no 2100 0.358726827025736 3006 28246688 SGTC_460 trequinsin 123 µM -0.36200647679268 0.38091356029856 no 2101 0.358673595229808 3113 5537 A vasodilator. SGTC_1676 st018489 23.4 µM -0.362026014542777 0.38090679013096 no 2102 0.358666295173349 3033 3696235 SGTC_1664 st014217 9.02 µM -0.362383232402814 0.380783014406799 no 2103 0.358532833917761 3119 3982782 SGTC_709 3807-1509 243 µM -0.36262000924066 0.380700978130334 no 2104 0.35844438051974 3088 1886677 YPL242C IQG1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.362872195749422 0.380613608750417 no 2105 0.358350178838879 3120 66535 A nucleotide analog. SGTC_3082 9117008 49.47 µM -0.363265549890053 0.380477344356887 no 2106 0.358203262649296 3073 41448529 SGTC_1766 st045414 44.774 µM -0.364138944023127 0.380174839193064 no 2107 0.357877128531619 3061 253960 SGTC_794 k038-0031 316 µM -0.365158510849816 0.379821798976852 no 2108 0.357496543274434 3127 6624242 SGTC_3125 9127534 49.47 µM -0.365542793957109 0.379688761189865 no 2109 0.357353134308325 3107 1639235 SGTC_3057 9095946 49.47 µM -0.366075783483699 0.379504265212139 no 2110 0.357154263578906 3011 24540043 SGTC_1257 0669-0121 16 µM -0.366272676932743 0.379436116870793 no 2111 0.357080807886754 3111 4307855 SGTC_507 nimesulide 162 µM -0.368149138354575 0.378786828271474 no 2112 0.35638101635822 3250 4495 A COX2 inhibitor. SGTC_3018 9082602 49.47 µM -0.368951198716892 0.378509405510242 no 2113 0.356082050105448 3120 17332089 SGTC_420 mitomycin C 81.9 mM -0.369231422783188 0.378412494220569 no 2114 0.355977618038177 3046 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1583 clindamycin 39.6 µM -0.370169618153924 0.378088089118772 no 2115 0.355628056224431 3056 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3290 9121031 71.43 µM -0.370582741131845 0.377945268496012 no 2116 0.355474169385613 3092 17014854 SGTC_658 3253-0951 102 µM -0.370882693133077 0.377841582629201 no 2117 0.355362453093017 3101 1184878 SGTC_2425 5628681 7.85 µM -0.371649021959232 0.377576721995723 no 2118 0.355077092496399 3142 5714958 SGTC_1014 4130-3005 69.3 µM -0.372715414097036 0.377208248471565 no 2119 0.354680131503796 3049 743608 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.374708765107132 0.376519780164726 no 2120 0.35393853641812 3012 88881 An O-methylated flavonoid and antioxidant. SGTC_1952 st077036 64.1 µM -0.377585848520657 0.375526778997127 no 2121 0.352869139512607 3072 2937007 SGTC_2303 7774051 200 µM -0.378829324322625 0.375097858416699 no 2122 0.352407304955333 3241 2953184 SGTC_1305 1181-0477 144 µM -0.37941292456795 0.374896606414872 no 2123 0.352190627194196 3211 6252086 SGTC_2393 9031399 185.94 µM -0.381778281154968 0.37408127281636 no 2124 0.351312914925886 3212 1526623 YDL150W RPC53 SGTC_1351 1496-0003 46.5 µM -0.381945514458148 0.374023649103549 no 2125 0.351250889644028 3214 3891978 SGTC_2492 derrusnin 100 µM -0.382968244716066 0.373671307414229 no 2126 0.350871654725488 3002 1715307 Part of coumarin class of compounds. SGTC_804 1595-0054 20.9 µM -0.383125813705089 0.373617032562082 no 2127 0.350813240330994 3073 761523 Stimulates phospholipase C. SGTC_2926 9010726 65.15 µM -0.383714928524452 0.373414133375044 no 2128 0.35059487336712 3189 2994293 SGTC_1015 4130-4525 82 µM -0.383800742445408 0.37338458081571 no 2129 0.350563068870892 3089 1363237 SGTC_585 0kpi-0023 191 µM -0.38588367453004 0.372667490401211 no 2130 0.349791410917558 3200 64601 SGTC_1076 itraconazole 331 nM -0.387381778063262 0.372152011290746 no 2131 0.349236795889054 3140 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_59 0330-0160 1.33 µM -0.387545060246083 0.372095841712788 no 2132 0.349176366388695 3131 4293482 SGTC_2369 9071472 200 µM -0.388383286799667 0.371807532047021 no 2133 0.348866205314647 3211 17296037 SGTC_152 4469-0003 551.229 µM -0.388825080872992 0.371655605023934 no 2134 0.348702773032168 3188 697280 SGTC_1930 st074634 34.3 µM -0.388920634964851 0.371622747888831 no 2135 0.348667428528017 3055 684253 YOR116C RPO31 SGTC_1848 st056003 16.4 µM -0.389930909122523 0.371275413280515 no 2136 0.348293818618281 3190 146492 SGTC_1408 3909-7976 48.8 µM -0.391216222134007 0.370833671198057 no 2137 0.34781870921047 3139 24152374 SGTC_967 1306-0166 352 µM -0.391299527483242 0.370805046312334 no 2138 0.347787924047016 3238 4437607 SGTC_264 promethazine 12.5 mM -0.392406676272382 0.370424682425182 no 2139 0.347378876938953 3210 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1200 1643-0193 18.4 µM -0.39297898720207 0.370228113124801 no 2140 0.347167500618902 3208 5403974 SGTC_1440 4100-1550 40 µM -0.394857106357333 0.369583281520283 no 2141 0.346474173629176 3140 742806 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.395634481804497 0.369316485369255 no 2142 0.346187347772244 3180 229346 A bile salt which induces apoptosis. SGTC_2647 atorvastatin 60.16 µM -0.396181061256864 0.369128936339246 no 2143 0.345985730813061 3167 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2526 patulin 37.61 µM -0.398229981492439 0.368426163334461 no 2144 0.345230333823245 3245 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1187 1391-0724 117 µM -0.399670933118583 0.36793218492675 no 2145 0.344699451870055 3161 6997986 SGTC_1841 st054148 70 µM -0.400377992558498 0.367689874842223 no 2146 0.344439065543476 3174 675442 SGTC_2887 9044784 58.44 µM -0.402183080865942 0.367071508007643 no 2147 0.34377464645237 3107 6465546 SGTC_1433 4060-0023 7.6 µM -0.402363189629824 0.367009827260289 no 2148 0.343708378226123 3232 3840627 SGTC_3081 9117243 49.47 µM -0.404287309087109 0.366351100347929 no 2149 0.343000728363868 3269 45595589 SGTC_1777 st045864 34.765 µM -0.408255134258084 0.364993950439496 no 2150 0.341543187180486 3206 4691462 SGTC_800 3448-7362 155 µM -0.408337360952643 0.364965843536278 no 2151 0.341513006905817 3204 15991913 SGTC_3095 9117207 49.47 µM -0.408707173204215 0.364839442499366 no 2152 0.34137728449684 3195 17015229 SGTC_2557 derrustone 83.84 µM -0.408781194816835 0.364814143834322 no 2153 0.341350120765535 3233 629853 An antioxidant. SGTC_1061 3448-9325 110 µM -0.408797938063652 0.36480842150896 no 2154 0.341343976605679 3201 723482 SGTC_395 anisomycin 6.25 µM -0.411142042895458 0.36400757656298 no 2155 0.340484191524042 3182 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1725 st036284 20.55 µM -0.411532098974993 0.363874374485253 no 2156 0.34034120464215 3317 707914 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.41386102216908 0.363079402382515 no 2157 0.339487945463497 3073 23665772 A membrane-active detergent. SGTC_2220 6782180 200 µM -0.413988296538511 0.363035974554527 no 2158 0.339441338973591 3182 833803 SGTC_607 4491-0986 66.8 µM -0.414109097840186 0.362994757058444 no 2159 0.339397105122163 3255 698981 YDR232W HEM1 SGTC_1354 1498-1681 81 µM -0.417427664885013 0.361863081556947 no 2160 0.33818281154403 3224 5754243 SGTC_820 1582-0060 59.9 µM -0.417667489609385 0.361781344778875 no 2161 0.338095122513104 3139 3848840 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.418005692783524 0.36166608949031 no 2162 0.33797147751066 3249 688662 SGTC_481 bay k-8644 50 µM -0.418083115458601 0.361639706603978 no 2163 0.337943174714555 3152 2303 A calcium channel antagonist. SGTC_2986 9022445 71.43 µM -0.42408087780225 0.359597891043429 no 2164 0.33575341533229 3279 6459286 SGTC_3029 9088683 49.47 µM -0.426127312816293 0.358902136709797 no 2165 0.335007539517188 3274 25236615 SGTC_1030 k029-0042 36.7 µM -0.426462608335335 0.358788186279346 no 2166 0.334885394371588 3183 6080581 SGTC_2839 9003951 25.97 µM -0.427762453993009 0.358346551646857 no 2167 0.334412037464859 3264 2990634 SGTC_2058 5236698 133 µM -0.429234516986729 0.357846633311958 no 2168 0.333876282977551 3165 766665 SGTC_1539 benzyladenosine 56 µM -0.429359358142067 0.357804247967597 no 2169 0.333830862833515 3146 92208 A nucleotide analog. SGTC_2025 5147754 141 µM -0.430843308612024 0.357300560126754 no 2170 0.333291153425904 3189 315777 YLR208W SEC13 SGTC_206 4546-0025 72.014 µM -0.431060532648891 0.357226849989933 no 2171 0.333212178458404 3237 6620745 YIL048W NEO1 SGTC_275 trichlorophene 5.69 µM -0.431147693607889 0.357197275358129 no 2172 0.333180491898883 3245 62616 SGTC_2266 7929956 200 µM -0.431956914761621 0.356922739071201 no 2173 0.332886363913967 3199 2967153 SGTC_2140 5586273 200 µM -0.432682035488544 0.356676797611086 no 2174 0.332622891269749 3250 854421 SGTC_1707 st032323 6.317 µM -0.432864756091732 0.356614833087111 no 2175 0.332556512764547 3196 3132057 YMR211W DML1 SGTC_1768 st044301 37.178 µM -0.433774992774253 0.356306208472081 no 2176 0.332225921408648 3202 3931349 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.43403085651742 0.356219472310719 no 2177 0.332133017042776 3205 688788 SGTC_2404 5161160 200 µM -0.434396074203749 0.356095678754455 no 2178 0.332000424031343 3160 2831543 SGTC_3271 9137798 49.47 µM -0.434753870791022 0.355974415349299 no 2179 0.331870545662 3249 6498326 SGTC_3350 9150499 3.57 µM -0.436536681537129 0.355370407549813 no 2180 0.33122369566425 3134 4910996 YPR165W RHO1 SGTC_339 3091-4833 71.4 µM -0.437347506694249 0.355095823873856 no 2181 0.330929673636324 3193 3240077 SGTC_1698 5-fluorocytosine 1.055 µM -0.438474984103804 0.354714131857359 no 2182 0.330521000225768 3292 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1149 3909-7961 23.3 µM -0.438575169732268 0.354680222435156 no 2183 0.33048469600189 3205 735261 SGTC_2944 9067346 25.62 µM -0.44097394810526 0.353868662077352 no 2184 0.329615928695621 3310 6473075 SGTC_121 0557-0495 61.343 µM -0.440980697789083 0.353866379442876 no 2185 0.329613485451706 3209 3104427 SGTC_2800 7887935 81.82 µM -0.441413703841684 0.353719954743244 no 2186 0.329456761548066 3294 2961002 SGTC_462 ag-879 158 µM -0.441977351364788 0.353529384931208 no 2187 0.329252797634547 3255 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_867 0518-0118 155 µM -0.4424498211375 0.353369670689892 no 2188 0.329081866833361 3283 6848158 SGTC_618 k072-0232 33.2 µM -0.442917034564978 0.353211758697608 no 2189 0.328912872814616 3254 5872756 YGL099W LSG1 SGTC_2656 pseudo-anisatin 100 µM -0.444125110375661 0.35280356217401 no 2190 0.328476066412668 3201 6708809 A neurotoxin. SGTC_849 0386-0493 241 µM -0.444989001361533 0.352511766043022 no 2191 0.328163851260333 3168 726119 SGTC_878 0828-0289 13.7 µM -0.445107848296956 0.352471629944667 no 2192 0.328120908682487 3198 745350 YLR208W SEC13 SGTC_357 1325-0123 420 µM -0.447304955017848 0.35172993578055 no 2193 0.327327444915854 3280 1098503 SGTC_1672 st016598 6.51 µM -0.447313579351556 0.351727025507522 no 2194 0.327324331855169 3195 4665860 YNL267W PIK1 SGTC_2721 ifenprodil 61.44 µM -0.448843821702102 0.351210784399711 no 2195 0.326772162098732 3324 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1978 st071761 42 µM -0.449650974397424 0.350938594618545 no 2196 0.326481063307972 3173 5147680 SGTC_1292 0kpi-0043 232 µM -0.45017588463418 0.350761624278223 no 2197 0.326291811644712 3244 3333905 SGTC_1138 3761-0006 1.03 µM -0.450462835354513 0.350664894247115 no 2198 0.326188373045129 3292 12061087 SGTC_2322 7413319 38.22 µM -0.452365960535944 0.350023603035167 no 2199 0.325502682439675 3286 1840400 SGTC_177 1327-0068 8.361 µM -0.453626757383906 0.349598990848171 no 2200 0.32504874572987 3299 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1609 st001574 46.4 µM -0.454964881995732 0.349148541902655 no 2201 0.32456725189317 3192 3960012 SGTC_1751 st044839 27.194 µM -0.455858568837189 0.348847821011366 no 2202 0.324245842092923 3292 5291326 SGTC_2936 9038235 15.59 µM -0.458714659007153 0.347887399023741 no 2203 0.323219542925485 3201 4749415 SGTC_439 amiodarone 34.4 µM -0.459223504081749 0.347716391046275 no 2204 0.323036836844379 3181 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3002 9075603 71.4286 µM -0.45944238726453 0.347642840324087 no 2205 0.322958257704893 3288 20105405 SGTC_1597 7-benzyloxygramine 47.5 µM -0.459614607898057 0.347584973522628 no 2206 0.322896435991409 3267 260807 SGTC_1136 pergolide 1.05886 µM -0.459628988674236 0.347580141686636 no 2207 0.322891273972857 3162 47811 A dopamine receptor agonist. SGTC_356 1634-0012 32.5 µM -0.459749058790889 0.347539799969034 no 2208 0.32284817581114 3327 735457 SGTC_68 0986-0284 82.829 µM -0.463047881061134 0.34643212305563 no 2209 0.32166502346897 3330 423278 YIL048W NEO1 SGTC_2032 5185112 25.99 µM -0.463469878136392 0.346290519542731 no 2210 0.32151380048697 3223 5718189 SGTC_1966 st070145 16.1 µM -0.464080960127175 0.346085505597189 no 2211 0.321294871202395 3156 3748532 SGTC_551 k048-0028 34.9 µM -0.464234263268259 0.346034080487073 no 2212 0.321239957791503 3342 6836383 SGTC_972 1319-0219 195 µM -0.464700495163796 0.345877701753289 no 2213 0.321072976859417 3270 23903702 SGTC_678 1218-2179 85.9 µM -0.466051838162812 0.345424596696987 no 2214 0.320589197898561 3278 6820081 YOR116C RPO31 SGTC_3079 9117512 49.47 µM -0.466624183840714 0.345232756008213 no 2215 0.320384390703086 3293 7185044 SGTC_1986 st071812 45 µM -0.466695657486093 0.345208802030618 no 2216 0.320358818536647 3300 11838594 SGTC_1228 0124-0032 52.5 µM -0.467288805147225 0.345010035968415 no 2217 0.320146632386051 3310 X1228 SGTC_1933 st074711 15.9 µM -0.467562955971341 0.344918181418106 no 2218 0.320048580538505 3290 17250958 SGTC_2277 7947813 106.88 µM -0.467708523654818 0.344869412511814 no 2219 0.319996522405814 3395 1246798 SGTC_1189 1431-2119 7.28 µM -0.467948822895038 0.344788911744302 no 2220 0.319910593986846 3318 3107275 SGTC_562 3772-2733 112 µM -0.469041585504451 0.344422922573434 no 2221 0.319519955782668 3329 2876874 YIL048W NEO1 SGTC_2959 9079155 11 µM -0.46904400786739 0.344422111434794 no 2222 0.319519090064289 3348 16189457 SGTC_377 3970-0964 33.1 µM -0.470829583724742 0.34382439855641 no 2223 0.318881218266905 3271 16481235 SGTC_102 gallobenzophenone 83.616 µM -0.470907801096951 0.343798224578249 no 2224 0.318853288456891 3373 70837 SGTC_894 0960-0238 55.9 µM -0.470908166097014 0.343798102439571 no 2225 0.318853158125309 3346 6741907 YDL195W SEC31 SGTC_2787 5284540 71.43 µM -0.471973440122546 0.343441703071444 no 2226 0.318472873281603 3250 736958 SGTC_449 xestospongin c 11.1929 µM -0.473102165235288 0.343064227263542 no 2227 0.318070146047611 3321 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_964 1287-0107 19.4 µM -0.475121556033666 0.342389279881517 no 2228 0.317350167463825 3363 51516812 YPR165W RHO1 SGTC_2895 9054447 58.44 µM -0.475218731117602 0.342356813414968 no 2229 0.317315538775727 3236 2697450 SGTC_57 miconazole 162.5 nM -0.477421348104041 0.341621225811638 no 2230 0.316531057744733 3286 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3025 9087895 49.47 µM -0.477465742495081 0.341606405998197 no 2231 0.316515254766298 3345 17173641 SGTC_681 1642-0006 26.6 µM -0.477538301908419 0.341582184613301 no 2232 0.316489426665005 3337 4446530 SGTC_1252 0493-0875 34.8 µM -0.477878620615096 0.341468589997759 no 2233 0.316368299453605 3215 3960963 SGTC_2461 5755302 26.15 µM -0.479304703512968 0.340992735580176 no 2234 0.315860938269622 3358 2788904 SGTC_1648 st011736 69.8 µM -0.479525787015245 0.34091898719776 no 2235 0.315782313841222 3389 2855514 SGTC_723 4182-0001 115 µM -0.480985613500456 0.340432175280923 no 2236 0.31526336179025 3252 744821 YLR208W SEC13 SGTC_1075 aripiprazole 15.2 µM -0.481235738397388 0.340348792164526 no 2237 0.315174481705011 3258 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3134 9127454 49.47 µM -0.482093967085932 0.340062747323307 no 2238 0.314869597658551 3384 24262820 SGTC_748 act1.228 77.9 µM -0.484371559232367 0.339304079822948 no 2239 0.314061099471049 3273 4421505 YNR035C ARC35 SGTC_1606 st000094 49.2 µM -0.484515077601057 0.339256295526503 no 2240 0.31401018323594 3378 1242210 SGTC_2221 6807166 181.081 µM -0.485431847708631 0.338951118866199 no 2241 0.313685022851716 3300 674925 SGTC_2868 9035608 32.47 µM -0.487278000023626 0.338336887987756 no 2242 0.313030668043286 3273 6462614 SGTC_3349 9149703 23.001 µM -0.487439928291686 0.338283033535059 no 2243 0.312973301828732 3322 4910494 SGTC_3102 9121669 49.47 µM -0.487694733535394 0.338198296556381 no 2244 0.31288304132125 3267 41905072 SGTC_2187 6125751 200 µM -0.489938380628421 0.337452512759217 no 2245 0.312088751442442 3306 874498 SGTC_1018 4259-0013 28.1 µM -0.492749047365744 0.336519153257734 no 2246 0.311094958475995 3349 6801262 SGTC_1737 st035557 69.7 µM -0.493622327333425 0.3362293611757 no 2247 0.310786464726509 3280 5716916 SGTC_171 k064-0041 9.68 µM -0.493659021556981 0.336217186573192 no 2248 0.310773505082068 3258 53325 SGTC_2338 7999974 200 µM -0.494206292634325 0.336035630488036 no 2249 0.310580248069729 3294 315925 SGTC_2515 chrysin 20.77 µM -0.495169706356301 0.335716112861772 no 2250 0.310240166239248 3322 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2017 5132927 60.65 µM -0.495578818798145 0.335580465999437 no 2251 0.310095799961048 3238 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2650 prasterone 100 µM -0.498032446797751 0.334767381957657 no 2252 0.309230586386152 3332 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_782 0083-0095 30.5 µM -0.498185902197657 0.334716555538967 no 2253 0.30917650905602 3325 3591729 An indicator and reagent. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.498863066235166 0.334492306202219 no 2254 0.308937927390232 3457 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1193 1488-0126 41.5 µM -0.499325116201585 0.334339327823175 no 2255 0.308775181986107 3295 1384710 SGTC_1210 3013-0140 750 nM -0.50001898690334 0.334109648469976 no 2256 0.308530854127389 3378 905973 SGTC_824 1304-0008 100 µM -0.500064302042729 0.334094650786239 no 2257 0.308514900570239 3287 768245 SGTC_228 caffeine 993.056 µM -0.500823639387179 0.333843376824562 no 2258 0.308247623589265 3368 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2916 7875993 68.79 µM -0.502003967855731 0.333452939691849 no 2259 0.30783236494553 3411 1299250 SGTC_1176 0848-0131 83.3 µM -0.502743213754678 0.333208498691253 no 2260 0.307572411528802 3347 6769040 SGTC_932 2857-0803 154 µM -0.503024654809971 0.33311545525989 no 2261 0.307473469078676 3460 674898 SGTC_984 1492-0255 2.91 µM -0.503860975420086 0.332839031210826 no 2262 0.30717953775254 3343 1585198 SGTC_1019 4262-0212 3.4 µM -0.504874227871372 0.332504248632481 no 2263 0.306823588283157 3377 4677213 SGTC_2242 6630449 61.2675 µM -0.505450122003639 0.332314030465202 no 2264 0.306621361270652 3382 691249 YDR170C SEC7 SGTC_111 0083-0039 52.457 µM -0.506220761934318 0.332059555213771 no 2265 0.306350840752066 3311 759313 SGTC_456 gingerol 170 µM -0.507110556448861 0.331765829902675 no 2266 0.306038624222942 3449 442793 A herb. SGTC_306 1672-3436 11.6 µM -0.508055434473285 0.331454034453193 no 2267 0.305707233856591 3379 6797378 SGTC_2445 5742597 35.57 µM -0.510171029290756 0.330756343861305 no 2268 0.304965823339013 3257 1774255 SGTC_3088 9117578 49.47 µM -0.510407267240201 0.330678472646906 no 2269 0.304883083309718 3414 678341 SGTC_441 propafenone 146 µM -0.510729215790492 0.330572360410061 no 2270 0.304770340043886 3281 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_719 2810-4230 27.3 µM -0.510914505173712 0.330511296356772 no 2271 0.304705461899044 3335 721079 SGTC_3107 9121808 49.47 µM -0.511538847448576 0.330305571056186 no 2272 0.304486896816038 3365 662681 SGTC_1465 k213-0056 144 µM -0.511545470464087 0.330303388999398 no 2273 0.304484578654205 3256 24048857 YMR208W ERG12 SGTC_2023 5144124 124 µM -0.513061385623764 0.329804098817186 no 2274 0.303954190769743 3264 2830192 SGTC_1808 st050063 61.5 µM -0.513887891470428 0.329532003912384 no 2275 0.303665186825806 3409 4011993 SGTC_485 niflumic acid 177 µM -0.514007621806148 0.329492594834439 no 2276 0.303623330944093 3399 4488 A COX2 inhibitor. SGTC_191 3914-0123 66.505 µM -0.514289216022314 0.329399915944183 no 2277 0.303524900096088 3261 3144412 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.515069543900505 0.329143147536742 no 2278 0.303252212118013 3456 5393153 SGTC_3355 9151058 44.0485 µM -0.515251856387442 0.329083168866175 no 2279 0.303188518245295 3390 17015728 SGTC_2750 bromebric acid 70.15 µM -0.516511562711588 0.328668860552997 no 2280 0.302748582648248 3418 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_62 0180-0423 3.232 µM -0.517093879587478 0.328477411851368 no 2281 0.302545312943917 3346 30102 YGL099W LSG1 SGTC_2112 5488546 200 µM -0.517548941812823 0.328327832081546 no 2282 0.302386506693541 3288 600757 SGTC_3252 9135871 49.47 µM -0.517876559613148 0.328220160557089 no 2283 0.302272198768544 3422 17682838 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.518713408179947 0.32794519523641 no 2284 0.301980305058113 3385 3256 An antibiotic and ribosome inhibitor. SGTC_2735 sertaconazole 140 nM -0.520855784164492 0.327241694817572 no 2285 0.301233619557958 3398 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1651 st011928 86.1 µM -0.520893177064837 0.327229421402121 no 2286 0.301220594341443 3401 720198 SGTC_2923 7992654 58.14 µM -0.521909053276156 0.32689605339363 no 2287 0.300866827287968 3348 2985126 SGTC_2624 nerol 100 µM -0.52236038221784 0.32674799043869 no 2288 0.30070971738753 3361 637566 A natural product oil. SGTC_2313 7726885 200 µM -0.522526561376393 0.326693480580471 no 2289 0.300651878904523 3387 726423 SGTC_3169 9102970 49.47 µM -0.522979999940871 0.326544763108965 no 2290 0.300494085635088 3421 17027839 SGTC_3230 9131665 49.47 µM -0.523194455244327 0.326474436276649 no 2291 0.300419469805115 3338 15943720 SGTC_3237 9133362 49.47 µM -0.52462546193107 0.326005320867428 no 2292 0.299921791430211 3390 43845137 SGTC_2245 6637752 200 µM -0.524948272612772 0.3258995344635 no 2293 0.299809575286931 3364 681890 SGTC_204 PMA1.184 62.41 µM -0.525068631797205 0.325860095843904 no 2294 0.299767740634376 3343 2252213 YGL008C PMA1 SGTC_457 grayanotoxin iii 135 µM -0.525502162640459 0.325718055050839 no 2295 0.299617075152131 3392 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2696 st077691 74.316 µM -0.527748897531894 0.324982346972477 no 2296 0.298836815015787 3428 757133 SGTC_2690 usnic acid 100 µM -0.528595820684499 0.324705193259778 no 2297 0.298542930059269 3519 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1624 st003710 6.25 µM -0.529403196456465 0.324441071667906 no 2298 0.298262890631225 3403 24207033 SGTC_2440 5628896 157.78 µM -0.529899506911027 0.324278754513836 no 2299 0.29809080403275 3335 5522048 SGTC_3120 9124077 49.47 µM -0.530037921254297 0.324233492384857 no 2300 0.298042819452168 3422 18774327 YGL155W CDC43 SGTC_692 k241-0027 77.8 µM -0.532078302919344 0.323566579812266 no 2301 0.29733588203502 3483 3600480 SGTC_1059 3448-6867 171 µM -0.533734846353242 0.323025543745528 no 2302 0.296762498339697 3418 3934407 SGTC_3273 9137859 49.47 µM -0.534929226028546 0.322635684972363 no 2303 0.296349398919319 3440 2377234 SGTC_3195 9113082 49.47 µM -0.535635828271906 0.322405133893177 no 2304 0.29610513099587 3422 17018038 SGTC_516 3992-2719 87.3 µM -0.536198946642842 0.322221447804694 no 2305 0.295910530719361 3248 5350887 YDR037W KRS1 SGTC_1943 st076331 65.2 µM -0.537011220563186 0.321956565031776 no 2306 0.295629931730845 3456 24208415 SGTC_2008 4012253 172 µM -0.537118112683469 0.321921714209386 no 2307 0.295593015092887 3348 603940 SGTC_635 k038-0028 24.7 µM -0.538268965882578 0.321546592359174 no 2308 0.295195686703915 3362 4035102 SGTC_1992 st073643 23.3 µM -0.53838270574966 0.321509528596661 no 2309 0.295156431732875 3390 3161292 SGTC_2333 9017922 200 µM -0.539000892440124 0.321308114702384 no 2310 0.294943119381855 3440 3163164 SGTC_2516 gossypol 71.55 µM -0.539317648353918 0.321204931536839 no 2311 0.294833846681751 3472 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2161 5662504 8.5105 µM -0.541810382596303 0.320393406108286 no 2312 0.293974569085023 3362 2859334 SGTC_960 1222-0186 7.7 µM -0.542061661617683 0.320311648177279 no 2313 0.293888014253843 3440 3126296 SGTC_2894 9048625 32.47 µM -0.542617158943797 0.320130938569008 no 2314 0.293696711124361 3492 4092861 SGTC_361 000s-0510 1.45 µM -0.542891284833185 0.320041778011648 no 2315 0.293602328419694 3375 660 SGTC_1695 st026914 34.495 µM -0.543484619218983 0.319848829192647 no 2316 0.293398088984143 3389 3289191 SGTC_2226 7298446 200 µM -0.544753509502403 0.319436357207384 no 2317 0.292961528624643 3427 3283010 SGTC_2359 9039622 200 µM -0.545039926819692 0.319343283800341 no 2318 0.292863028762727 3392 6463596 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.545546810360451 0.319178596177157 no 2319 0.292688747524695 3449 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2892 9047358 58.44 µM -0.546202036506353 0.318965764571246 no 2320 0.292463533212362 3354 6466771 SGTC_3163 9099914 49.47 µM -0.5464153419143 0.318896491239293 no 2321 0.292390233267814 3429 16268368 SGTC_3254 9136651 49.47 µM -0.547685577729392 0.318484098935676 no 2322 0.291953908363033 3383 16454030 SGTC_3229 9132204 49.47 µM -0.547723484186791 0.31847179575019 no 2323 0.291940892187996 3397 17682924 SGTC_1100 amiodarone 5.07 µM -0.553637875762899 0.316554638705535 no 2324 0.289913349671723 3463 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1090 efavirenz 20.7 µM -0.553689194845752 0.316538025015295 no 2325 0.289895785651923 3444 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2087 5276107 200 µM -0.553701391550181 0.31653407659174 no 2326 0.289891611388094 3425 144405 SGTC_2972 9093619 59.92 µM -0.554435367205096 0.316296506091787 no 2327 0.289640463634142 3311 25236256 SGTC_2996 9066192 71.4286 µM -0.555148619127361 0.316065715991329 no 2328 0.289396504907117 3397 6472854 SGTC_1833 st055984 71 µM -0.555578616603263 0.315926614409307 no 2329 0.289249476409972 3377 676288 SGTC_3109 9122853 49.47 µM -0.556226894823453 0.315716949592267 no 2330 0.289027877846097 3425 1234709 SGTC_851 0394-0702 453 µM -0.556463045513743 0.31564058894785 no 2331 0.288947175171136 3473 762646 SGTC_1283 0922-0125 16.4 µM -0.556505368112851 0.315626904530621 no 2332 0.288932712870149 3423 3360884 SGTC_2405 ticlatone 3.52 µM -0.556711623941261 0.315560218227351 no 2333 0.288862236869156 3201 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_677 0929-0063 136 µM -0.558350534239815 0.315030541987222 no 2334 0.288302521835656 3423 1539583 SGTC_3267 9137951 49.47 µM -0.558555428555052 0.314964349302508 no 2335 0.288232583012141 3394 16643986 SGTC_2336 9001819 198.65 µM -0.559212915337061 0.314751983278721 no 2336 0.288008209897605 3555 2989602 SGTC_2115 tiliquinol 12.7705 µM -0.559260915100138 0.314736481914626 no 2337 0.287991832788425 3397 71208 A bioactive hydroxyquinoline. SGTC_2468 5987765 72.9 µM -0.560018077059345 0.314492002180635 no 2338 0.287733553775272 3396 26772094 SGTC_648 0375-0473 33.3 µM -0.56243340340994 0.313712662291114 no 2339 0.286910382881636 3440 1713139 SGTC_2000 st075254 36.4 µM -0.562563598366832 0.313670676571892 no 2340 0.286866042661006 3435 17234175 SGTC_1327 1436-0082 2.18 µM -0.562980375328832 0.313536289128252 no 2341 0.286724123653861 3387 15992205 SGTC_2741 miltefosine 3.04 µM -0.562995891487678 0.313531286505676 no 2342 0.286718840804337 3364 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_391 gliotoxin 8.33 µM -0.563431662257741 0.313390802038982 no 2343 0.286570491014433 3520 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2876 9059903 25.97 µM -0.564373320890132 0.313087321116579 no 2344 0.286250045822253 3454 6916095 SGTC_286 k060-0067 22.9 µM -0.564566119568869 0.313025200912234 no 2345 0.286184457677307 3413 5985051 SGTC_280 3448-3607 3.04 µM -0.565063553850121 0.312864950888809 no 2346 0.286015268579762 3473 626179 SGTC_1530 rhein 70.4 µM -0.565558060857801 0.312705678938596 no 2347 0.28584712224717 3469 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_514 4466-0038 2.65 nM -0.566563580139107 0.312381926839226 no 2348 0.285505362363215 3428 5722064 SGTC_1888 azatryptophan 97.5 µM -0.567737808056831 0.312004038027516 no 2349 0.285106507502855 3437 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_989 1501-0895 10.3 µM -0.568358381516428 0.311804405570944 no 2350 0.284895822082473 3491 2830112 SGTC_2249 haloperidol 116.36 µM -0.570303839440693 0.311178929169208 no 2351 0.284235818628358 3464 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1161 k007-0610 110 µM -0.570337917038885 0.311167977867398 no 2352 0.284224264200376 3537 5843850 SGTC_2272 7805186 180 µM -0.572323378436946 0.310530211571924 no 2353 0.283551457134973 3476 2956062 YPR165W RHO1 SGTC_1074 carmofur 3.8 µM -0.572331970909326 0.31052745274905 no 2354 0.283548547090109 3500 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1816 st051957 91.6 µM -0.573005885372274 0.310311109276875 no 2355 0.283320354538593 3468 674121 SGTC_251 melphalan 456.522 µM -0.576095392404195 0.309320140798952 no 2356 0.282275352826652 3487 460612 A DNA alkylator. SGTC_3302 9125395 16.351 µM -0.576656193654635 0.309140410490822 no 2357 0.28208586524388 3384 17599668 SGTC_1770 st043884 66.3 µM -0.577231485031489 0.308956083719199 no 2358 0.281891545296186 3493 670149 SGTC_3332 9141069 11.198 µM -0.577327950964712 0.308925180169304 no 2359 0.281858967679346 3421 17332883 SGTC_3020 9089140 49.47 µM -0.577346822422322 0.308919134721402 no 2360 0.281852594790728 3498 17217859 SGTC_660 4031-1742 102 µM -0.577965680965397 0.308720912849096 no 2361 0.2816436448291 3426 6738706 SGTC_164 4100-3994 89.624 µM -0.577994406006954 0.308711713502207 no 2362 0.281633947987038 3539 4615967 SGTC_2786 7743617 45.45 µM -0.578983993223708 0.308394866279851 no 2363 0.281299986904775 3376 583674 SGTC_472 calcifediol 10 µM -0.580767572752029 0.307824158040666 no 2364 0.28069855638814 3464 5283731 A vitamin D metabolite. SGTC_1671 st016596 74.5 µM -0.581287278219368 0.307657950483279 no 2365 0.280523426613774 3514 2829167 SGTC_541 4513-1321 94 µM -0.581867232178716 0.30747252139044 no 2366 0.280328056823017 3412 747515 SGTC_1397 3532-0190 20.1 µM -0.582750840728083 0.307190099175249 no 2367 0.280030521281411 3408 5322280 SGTC_1873 rapamycin 2 nM -0.585529653285018 0.30630267058478 no 2368 0.279095816891857 3487 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_313 3474-0040 5.03 µM -0.585729291299377 0.306238958765276 no 2369 0.279028723448498 3460 1043375 YIL048W NEO1 SGTC_1998 st075797 76.8 µM -0.585740174290333 0.306235485771713 no 2370 0.279025066167459 3509 24208315 SGTC_1211 1056-0033 32.3 µM -0.588722125264549 0.30528453872951 no 2371 0.278023846636375 3519 6741922 SGTC_1657 st012939 43.4 µM -0.589432632092088 0.305058150826442 no 2372 0.277785545791149 3518 24207257 SGTC_2389 9091542 195.52 µM -0.590280047326148 0.304788237491512 no 2373 0.277501456949491 3443 3626624 YOL127W RPL25 SGTC_2473 5854593 8.94 µM -0.590304863826689 0.304780334696953 no 2374 0.277493139566578 3456 2872951 SGTC_99 0109-0120 622.8 µM -0.592665003750384 0.304029166720964 no 2375 0.276702683333957 3556 759414 SGTC_2629 bisabolol 100 µM -0.593532292634958 0.303753339894108 no 2376 0.276412489072817 3535 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3233 9132340 49.47 µM -0.594302586668427 0.303508454341866 no 2377 0.276154874441338 3438 17682950 SGTC_2449 5812982 45.77 µM -0.596458120200172 0.302823653933614 no 2378 0.27543461173914 3503 776185 SGTC_1627 st003713 25.6 µM -0.597591039928685 0.302464009556534 no 2379 0.275056422135166 3506 16195070 YER133W GLC7 SGTC_1733 st037357 54.9 µM -0.598822430420017 0.302073323079523 no 2380 0.274645651469438 3476 1272339 YGL099W LSG1 SGTC_2978 9011784 42.97 µM -0.600846805304951 0.301431537359046 no 2381 0.273971013094708 3504 2994934 SGTC_2080 5212524 12.4 µM -0.601133961071246 0.301340550352541 no 2382 0.273875382619031 3514 260183 SGTC_2730 imipramine 71.33 µM -0.601231417238959 0.301309673598944 no 2383 0.273842930885327 3545 3696 A tricyclic antidepressant. SGTC_2533 agelasine 13.65 µM -0.602666476777695 0.300855172912296 no 2384 0.273365293535384 3583 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2568 diosmetin 100 µM -0.603269915501106 0.300664148979187 no 2385 0.273164571581902 3541 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1660 st012960 28.1 µM -0.604394311798004 0.300308357383719 no 2386 0.272790758321788 3491 24207266 SGTC_1124 fisetin 1.16336 µM -0.606209588684845 0.299734353099979 no 2387 0.272187793145608 3481 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_510 ag-490 170 µM -0.606695889399835 0.299580665566082 no 2388 0.272026375321213 3616 5328779 SGTC_2495 cafestol 54.53 µM -0.607304346977589 0.299388422626074 no 2389 0.271824477026475 3558 16667697 An anti-infammatory. SGTC_2154 5570129 200 µM -0.60762555114499 0.299286960330174 no 2390 0.271717925190621 3552 673366 SGTC_702 1488-0190 94 µM -0.608111623610105 0.299133448941558 no 2391 0.271556721766903 3527 949357 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.610295398706632 0.298444210582153 no 2392 0.27083307221084 3579 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_470 aa-861 153 µM -0.611025098720294 0.298214065429327 no 2393 0.270591482230597 3494 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1946 st076057 65.1 µM -0.611556079252917 0.298046646616576 no 2394 0.2704157522306 3457 953009 SGTC_2648 atorvastatin 78.68 µM -0.611576289569912 0.298040275125079 no 2395 0.270409064677287 3544 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2378 9074213 121.43 µM -0.6117155691692 0.297996367616391 no 2396 0.27036297958531 3535 657714 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.614928154511844 0.296984428327591 no 2397 0.269301084252705 3507 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2711 st079103 59.1 µM -0.615755886964578 0.296723953977391 no 2398 0.26902782294041 3514 54693780 SGTC_2273 7815444 169.05 µM -0.616608116960815 0.296455879981196 no 2399 0.268746619679216 3541 2824616 SGTC_2036 5160441 105 µM -0.618252701521256 0.29593888018907 no 2400 0.268204387477365 3562 134534 YIL048W NEO1 SGTC_3303 9125618 40.5795 µM -0.619414085818233 0.295574031227697 no 2401 0.267821802045491 3537 22695467 SGTC_1713 st033146 12.748 µM -0.620708082279053 0.295167765890625 no 2402 0.267395855316189 3574 674619 SGTC_70 0141-0289 43.283 µM -0.621711337416099 0.294852959249843 no 2403 0.267065847671876 3551 352408 SGTC_1097 itavastatin 7.23 µM -0.622043216097318 0.294748854698395 no 2404 0.266956725808055 3564 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_885 0865-0106 16.8 µM -0.622524449968624 0.294597930143532 no 2405 0.266798535902159 3523 2793380 SGTC_2865 9030313 51.95 µM -0.623446778675428 0.294308769132382 no 2406 0.266495482940172 3496 42562754 SGTC_2367 9070478 135.38 µM -0.626546393952753 0.293337964684787 no 2407 0.265478308266577 3539 572802 SGTC_1649 st011737 51.3 µM -0.626767720323967 0.293268701713112 no 2408 0.265405752871736 3522 1761035 SGTC_3101 9120531 49.47 µM -0.628448616518143 0.292742921306188 no 2409 0.264855048701976 3635 24824904 SGTC_3016 9080866 49.47 µM -0.629030031817657 0.29256115790427 no 2410 0.264664697615207 3557 17066299 SGTC_3341 9147222 25.867 µM -0.629967862262139 0.292268081739763 no 2411 0.264357805535968 3547 1939759 SGTC_1610 st001799 48.1 µM -0.632116856619391 0.291597027011078 no 2412 0.263655260580874 3491 621897 SGTC_1655 st012546 55.1 µM -0.63344147317621 0.291183754422512 no 2413 0.263222694547666 3539 720985 YLR208W SEC13 SGTC_3054 9094397 49.47 µM -0.635404568679077 0.290571783633968 no 2414 0.262582294579964 3528 2598354 SGTC_1780 st038448 24.544 µM -0.635456559044877 0.290555584462433 no 2415 0.262565345155229 3599 728868 YDL195W SEC31 SGTC_3039 9090270 49.47 µM -0.635535963394723 0.290530844450302 no 2416 0.262539459554224 3568 17173750 SGTC_1218 1348-1416 30.7 µM -0.636726878001797 0.290159909525697 no 2417 0.262151381415548 3571 6787668 SGTC_324 1315-0088 19.6 µM -0.63711685116361 0.290038492587248 no 2418 0.262024366483703 3538 6787421 SGTC_759 3486-0358 89.3 µM -0.638748485247592 0.289530746821718 no 2419 0.26149328277434 3618 875103 SGTC_511 blebbistatin 171 µM -0.63881153536974 0.289511134727776 no 2420 0.261472771565372 3629 3476986 A myosin inhibitor. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.640070281935305 0.289119725172392 no 2421 0.26106345420167 3585 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1839 st053978 48 µM -0.642794585371765 0.288273451197221 no 2422 0.260178698506637 3623 3788398 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.644617275544461 0.287707906218544 no 2423 0.259587618413935 3608 4213774 SGTC_2093 5331342 194.4 µM -0.645214265524392 0.287522785991692 no 2424 0.259394171406457 3600 33839 SGTC_865 0488-0499 301 µM -0.646257491213278 0.287199428094977 no 2425 0.259056306258949 3607 9634651 SGTC_2937 9044753 11.33 µM -0.646640442742574 0.287080771769466 no 2426 0.258932338471206 3592 6465530 YGL099W LSG1 SGTC_1704 st028805 70.8 µM -0.64892030760404 0.286374843744625 no 2427 0.258194943930177 3574 2876101 SGTC_1045 1348-1485 165 µM -0.648966322475969 0.286360604374809 no 2428 0.258180072195635 3633 6810614 SGTC_2159 5658611 73.75 µM -0.648977025289319 0.286357292421649 no 2429 0.258176613173301 3612 793844 SGTC_1416 3966-0321 25.3 µM -0.648982697947784 0.286355537042049 no 2430 0.258174779847107 3594 582530 YLR208W SEC13 SGTC_609 0986-0026 86.3 µM -0.650396922157422 0.285918070940761 no 2431 0.257717932459123 3590 2848610 SGTC_1656 st012921 11 µM -0.650430037137546 0.285907831195308 no 2432 0.257707240110847 3551 6732821 SGTC_2108 5365811 200 µM -0.650675318547224 0.285831991215371 no 2433 0.257628049461001 3606 780283 SGTC_991 3996-0057 64.7 µM -0.651635498653226 0.285535199625922 no 2434 0.257318170851394 3586 715343 SGTC_1199 1638-0010 4.46 µM -0.652224418779203 0.285353237072612 no 2435 0.257128204741388 3573 3111136 SGTC_21 0849-0113 22.993 µM -0.652561317613215 0.285249168048753 no 2436 0.257019565147429 3579 1560156 SGTC_1555 citronellol 128 µM -0.653743963175386 0.284883988648817 no 2437 0.256638387147548 3569 8842 A terpine precursor. SGTC_2348 9022543 33.42 µM -0.654269881074597 0.28472166645614 no 2438 0.256468973380478 3613 3162678 YDL140C RPO21 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.655338180507468 0.284392076623568 no 2439 0.256125021891044 3602 97141 SGTC_2083 5306046 65.942 µM -0.656249881463207 0.284110944532091 no 2440 0.255831679476085 3628 539837 SGTC_521 r062-0005 13.8 µM -0.656318058749514 0.284089926727859 no 2441 0.255809750286524 3542 2832033 SGTC_1735 st034310 56.75 µM -0.657674804181784 0.283671821786684 no 2442 0.255373557937307 3618 871153 SGTC_1065 prochlorperazine maleate 2.48 µM -0.657862923355283 0.283613872832887 no 2443 0.255313108504724 3644 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_281 1672-3440 14.9 µM -0.660328577597857 0.282854867991679 no 2444 0.254521497446218 3610 6833000 SGTC_2199 6590217 200 µM -0.662356390239074 0.282231376368585 no 2445 0.253871422664976 3562 703109 SGTC_3179 9107801 49.47 µM -0.662576920169189 0.282163609921359 no 2446 0.253800777910893 3619 4818259 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.662603020772857 0.282155590008339 no 2447 0.253792417503347 3639 1273210 SGTC_2381 9035592 200 µM -0.66492154907605 0.281443615719463 no 2448 0.253050336009327 3571 4749657 SGTC_523 1934-0222 13.7 µM -0.665576428888306 0.281242672172193 no 2449 0.252840938359664 3632 1361595 SGTC_536 3852-0578 10.6 µM -0.666153332065766 0.281065712412709 no 2450 0.252656549316849 3639 2869208 SGTC_833 3852-0053 558 µM -0.667057063760841 0.280788609186301 no 2451 0.252367842204599 3659 3123681 SGTC_1674 st016616 23.6 µM -0.667200931272168 0.280744508560617 no 2452 0.252321898183054 3612 625830 SGTC_380 3970-0968 6 µM -0.668888605962618 0.280227425161339 no 2453 0.251783269500806 3592 2891601 SGTC_2350 9023895 38.85 µM -0.669658653079976 0.279991645288138 no 2454 0.251537707476067 3628 2997209 SGTC_1122 capsaicin 818.572 nM -0.671164343508083 0.279530897685364 no 2455 0.251057920380563 3664 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2103 5378138 10 µM -0.673022030267878 0.278962945503933 no 2456 0.250466637779684 3675 244142 SGTC_2128 5255449 168.493 µM -0.673804340035856 0.278723937343822 no 2457 0.250217857628686 3642 736008 SGTC_3067 9117431 49.47 µM -0.674121962023486 0.278626927202179 no 2458 0.250116888960011 3629 17150885 SGTC_2305 7443522 69.23 µM -0.675616958639718 0.278170536716718 no 2459 0.249641935773591 3609 5415886 SGTC_701 4424-0219 185 µM -0.676537659984676 0.277889647810449 no 2460 0.249349671951512 3670 2911779 SGTC_753 1322-0200 289 µM -0.676600817946015 0.277870384563234 no 2461 0.249329630004851 3674 5403907 SGTC_1565 sinapyl alcohol 95.1 µM -0.676702350414688 0.277839418415678 no 2462 0.249297412452146 3618 5280507 A phenol propionate derived from cinnamic acid. SGTC_2736 butenafine 14.65 µM -0.677033932101035 0.277738301837841 no 2463 0.249192212755408 3622 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3262 9137218 49.47 µM -0.677111624770095 0.277714611883509 no 2464 0.249167566903749 3515 17650664 SGTC_2117 5521686 200 µM -0.67785278809786 0.277488666888142 no 2465 0.248932518515417 3635 803312 SGTC_1878 temozolomide 1 mM -0.678168873983055 0.277392334864667 no 2466 0.248832312713905 3606 5394 DNA alkylating agent. SGTC_1572 epiandrosterone 68.9 µM -0.67924658715409 0.277064008202168 no 2467 0.248490816705719 3600 441302 A steroid. SGTC_1871 st057448 67.3 µM -0.68020433159505 0.276772389869275 no 2468 0.248187545014185 3723 691747 SGTC_3268 9137683 49.47 µM -0.68215081815527 0.276180178623643 no 2469 0.247571794913596 3653 1953228 SGTC_2304 7443016 91.4 µM -0.683625807779633 0.275731833142973 no 2470 0.24710574188224 3603 939854 SGTC_2 0422-0095 29 µM -0.685464732568185 0.275173365547163 no 2471 0.246525354022221 3548 6790840 SGTC_827 3253-0474 693 µM -0.686079715438558 0.274986724235731 no 2472 0.246331420757964 3654 5402065 SGTC_2934 9036370 36.88 µM -0.68834945866931 0.274298419622816 no 2473 0.24561637152397 3670 6462800 SGTC_1084 voriconazole 435 nM -0.689370006975364 0.27398921357883 no 2474 0.245295226472424 3665 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_729 4092-0585 94.1 µM -0.689832165691337 0.273849245278564 no 2475 0.245149869149631 3650 2169061 SGTC_1204 4049-0315 18.3 µM -0.690420705918525 0.273671052565171 no 2476 0.244964829617331 3686 588402 SGTC_2977 9011197 71.43 µM -0.690962938276456 0.273506931302108 no 2477 0.244794416008016 3661 2704722 SGTC_2714 st079313 56.9 µM -0.691132161431606 0.273455721321676 no 2478 0.244741245366296 3662 2939799 SGTC_163 TUB2.036 7.546 µM -0.691644179484591 0.273300804334279 no 2479 0.244580404970292 3702 15992207 YJR013W GPI14 SGTC_1037 k284-1091 78.7 µM -0.692111978515444 0.273159304334002 no 2480 0.244433504893434 3637 3334711 SGTC_997 3996-0078 137 µM -0.696464325334656 0.27184454776142 no 2481 0.243069045587474 3703 735687 SGTC_2447 5741742 33.78 µM -0.697584145840039 0.271506782463525 no 2482 0.242718649660232 3713 1776504 SGTC_258 haloperidol 50.781 µM -0.697769688058309 0.271450838578134 no 2483 0.242660619239192 3678 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_288 1315-0019 35.1 µM -0.698442875934662 0.271247910114796 no 2484 0.242450135222548 3716 6811474 SGTC_2029 5175081 200 µM -0.698610027894526 0.271197534877221 no 2485 0.242397887557479 3679 1380876 SGTC_106 0092-0003 11.579 µM -0.699903861357846 0.270807765096738 no 2486 0.241993672902328 3631 1072148 SGTC_2597 laccaic acid a 100 µM -0.699967170851604 0.2707887001703 no 2487 0.241973903371574 3658 5491415 A textile dye. SGTC_764 1951-2361 146 µM -0.701758556229759 0.270249522909235 no 2488 0.241414874245447 3654 5438930 SGTC_1365 1672-3266 55.4 µM -0.702457692705049 0.270039240168898 no 2489 0.241196888534605 3675 6415873 SGTC_1213 1315-0166 115 µM -0.705716690478242 0.269060096828921 no 2490 0.240182169690205 3681 768401 SGTC_227 fluconazole 33.516 µM -0.706688740761893 0.268768396403831 no 2491 0.239879964010387 3662 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2365 9042475 200 µM -0.707336131064904 0.268574210644646 no 2492 0.239678808653606 3721 6464479 SGTC_328 k915-0120 63.5 µM -0.70828113019543 0.268290883289753 no 2493 0.239385346428272 3676 6624543 SGTC_1784 st039334 36.3 µM -0.709219593466804 0.268009664378044 no 2494 0.239094108187032 3732 3496984 SGTC_3323 9138564 53.9225 µM -0.710540129672773 0.267614205397574 no 2495 0.238684627446073 3694 43912313 YNL103W MET4 SGTC_2136 5328288 199.296 µM -0.7124246978667 0.267050346496456 no 2496 0.238100913070672 3695 262395 SGTC_3288 9119690 36.221 µM -0.713216107306921 0.266813737418584 no 2497 0.237856020298981 3696 17595618 YKL019W RAM2 SGTC_2318 6029776 164 µM -0.713521008655036 0.266722608800248 no 2498 0.237761708869036 3694 818325 SGTC_3279 9140807 49.47 µM -0.71386435402192 0.266620008906813 no 2499 0.237655530576752 3726 45595718 SGTC_858 0438-0351 2.77 µM -0.714573538003889 0.26640815078867 no 2500 0.237436300426366 3713 2799119 SGTC_610 4215-0184 155 µM -0.714600368569959 0.26640013723037 no 2501 0.237428008469668 3728 5605015 SGTC_2028 5153890 36.43 µM -0.714821822318947 0.266333999693378 no 2502 0.237359574505721 3674 2830968 YPR165W RHO1 SGTC_1087 pterostilbene 9.05 µM -0.716296669162278 0.26589374622987 no 2503 0.236904091533295 3714 5281727 Similar to reservatol, lowers cholesterol. SGTC_1836 st055642 81 µM -0.717352352640431 0.265578842957193 no 2504 0.236578355793915 3710 8571 SGTC_1714 st033236 13.627 µM -0.717530516353846 0.265525716583075 no 2505 0.236523406917894 3721 2916566 SGTC_2813 7971799 71.43 µM -0.718398648356297 0.265266926743993 no 2506 0.236255759994878 3744 2234054 SGTC_3099 9120367 49.47 µM -0.720108313333031 0.264757650900613 no 2507 0.235729154683375 3731 24824940 SGTC_1166 k206-0078 225 µM -0.72110275249606 0.264461655723071 no 2508 0.235423148838413 3720 5404595 SGTC_807 1315-0151 48 µM -0.721191746053374 0.264435174970695 no 2509 0.235395774698568 3716 4011080 SGTC_1104 tacrolimus 29.8 µM -0.723010325466245 0.263894337685233 no 2510 0.234836770278157 3749 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_680 0417-1641 114 µM -0.723868506180032 0.26363931460146 no 2511 0.234573233256588 3701 2835990 SGTC_169 k015-0017 16.025 µM -0.725252965380322 0.263228164053535 no 2512 0.234148427435821 3738 1840002 SGTC_1157 4092-0394 27.6 µM -0.726541577469709 0.26284577226255 no 2513 0.233753414296602 3799 3659885 SGTC_1068 loratadine 26.9 µM -0.726610552255434 0.262825312213172 no 2514 0.233732281079112 3744 3957 A H1 histamine antagonist. SGTC_3186 9110464 49.47 µM -0.727034795386727 0.262699486525596 no 2515 0.233602320316684 3700 17018021 SGTC_2202 7226349 200 µM -0.727483252271977 0.262566512828084 no 2516 0.233464985595703 3669 844334 SGTC_341 1486-1430 230 µM -0.727746065436044 0.262488601085981 no 2517 0.233384522930022 3690 2054753 YPL210C SRP72 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.727919436424551 0.262437211221589 no 2518 0.233331452231966 3779 6728940 SGTC_1147 3809-1045 12.3 µM -0.72875854896413 0.26218855800149 no 2519 0.233074685647199 3691 325925 SGTC_821 1114-0266 29.2 µM -0.729117209770768 0.262082313307862 no 2520 0.232964984111984 3744 3123235 SGTC_3077 9117319 49.47 µM -0.730525833951928 0.261665255672603 no 2521 0.232534413880354 3707 17154678 SGTC_2965 9082772 38.63 µM -0.730588035631416 0.261646847198937 no 2522 0.2325154110725 3718 16459634 SGTC_1247 0448-0043 5.84 µM -0.731510801438932 0.261373834425262 no 2523 0.232233604676333 3786 3089013 YGL099W LSG1 SGTC_559 1550-0661 158 µM -0.732997138398931 0.260934389328534 no 2524 0.231780087364873 3761 5830875 SGTC_143 4032-1194 15.74 µM -0.733937781730182 0.260656478519363 no 2525 0.231493329487059 3748 1806963 SGTC_1039 k821-0043 94 µM -0.734516408809074 0.260485600252345 no 2526 0.231317031629195 3694 15992768 SGTC_2693 st077581 40.7 µM -0.73468002896037 0.260437290945857 no 2527 0.231267192929455 3781 25238761 SGTC_2809 7964133 12.99 µM -0.735256994226297 0.26026697717131 no 2528 0.231091497115334 3770 1253665 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.735617017637647 0.260160731322557 no 2529 0.230981901569846 3707 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_482 fipronil 114 µM -0.737690566831111 0.259549245476283 no 2530 0.230351252862191 3772 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_557 1315-0110 16.2 µM -0.739118537217004 0.259128571571815 no 2531 0.229917510730264 3739 6833801 SGTC_3345 9148410 3.559 µM -0.739150683373136 0.25911910551181 no 2532 0.229907751687054 3693 4903596 SGTC_529 4076-0302 30.3 µM -0.740264953287145 0.258791097631051 no 2533 0.229569621057461 3715 5816522 SGTC_1685 st024049 53.0905 µM -0.740641820722685 0.258680207728152 no 2534 0.229455321882715 3743 1941139 SGTC_3130 9127414 49.47 µM -0.740955163649586 0.258588028080225 no 2535 0.229360313182765 3741 1494646 SGTC_2349 9023730 187.07 µM -0.741563133615084 0.258409223179666 no 2536 0.229176033544143 3720 4126287 SGTC_2587 piperic acid 92.2 µM -0.744223673036519 0.257627508604585 no 2537 0.228370584289937 3759 5370536 SGTC_2769 toremifene 3.73 µM -0.744873689803533 0.257436708749505 no 2538 0.228174040894783 3756 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_993 3909-8757 62.7 µM -0.745729210847677 0.257185699032989 no 2539 0.227915504876751 3727 4288324 YLR208W SEC13 SGTC_3235 9132602 49.47 µM -0.746502422418783 0.2569589484222 no 2540 0.227681984401366 3752 4912240 SGTC_3033 9090887 49.47 µM -0.747394516495773 0.256697463830218 no 2541 0.227412727206214 3785 19325384 SGTC_2433 5607874 27.82 µM -0.747957468148826 0.256532526569162 no 2542 0.227242906108442 3757 2252428 SGTC_2756 carbadox 75.1 µM -0.748407528837795 0.256400704561639 no 2543 0.22710719134229 3774 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3215 9129942 49.47 µM -0.749409192400982 0.256107445766961 no 2544 0.226805306073019 3689 17682944 SGTC_2898 9056270 58.44 µM -0.749570497090744 0.256060236669441 no 2545 0.226756712610193 3704 19154699 SGTC_3316 9136639 10.545 µM -0.749846465624135 0.255979479393696 no 2546 0.226673589986479 3789 4903665 SGTC_1078 idebenone 36.1 µM -0.750316706388208 0.255841902428772 no 2547 0.226531991555937 3799 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_44 0929-0055 61.211 µM -0.753724508961254 0.254846046026846 no 2548 0.225507330955505 3719 1379590 SGTC_2201 6605497 169.863 µM -0.754243073545403 0.254694684835301 no 2549 0.225351638867372 3742 670741 SGTC_2759 disulfiram 3.38 µM -0.756364588668145 0.254075937122622 no 2550 0.224715316539018 3717 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2903 5923464 63.88 µM -0.758060232357743 0.253581963959715 no 2551 0.224207462640959 3789 2876576 SGTC_150 3970-0969 77.2 µM -0.758114744348567 0.253566091957347 no 2552 0.224191146842984 3862 6615640 SGTC_2351 9026858 72.31 µM -0.761110496959526 0.252694635694673 no 2553 0.223295535625267 3716 1409300 SGTC_2834 9001755 58.44 µM -0.76277651893086 0.252210677825342 no 2554 0.222798343523368 3725 2989575 SGTC_2031 5180455 200 µM -0.763397803471954 0.252030327894492 no 2555 0.222613094752809 3756 29949 SGTC_1705 st027868 56.3335 µM -0.763940641149287 0.251872805672329 no 2556 0.222451308431616 3786 292948 SGTC_499 genistein 192 µM -0.765382813409441 0.251454564485338 no 2557 0.222021812004741 3780 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2589 lobaric acid 100 µM -0.766428836950783 0.251151439315904 no 2558 0.221710589927567 3796 73157 A novel microtubule depolymerizer. SGTC_291 SEC14.278 35.5 µM -0.767373574200042 0.250877831908815 no 2559 0.221429717782047 3759 1068044 SGTC_2582 agaric acid 100 µM -0.767456116026905 0.250853934288047 no 2560 0.221405187610501 3651 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2732 terfenadine 20 µM -0.769218975375189 0.250343836706755 no 2561 0.220881663795511 3774 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3337 9144342 33.5465 µM -0.769847275800609 0.250162165912088 no 2562 0.2206952462025 3792 17682949 SGTC_2638 epoxomicin 18 µM -0.770466457697103 0.249983200140038 no 2563 0.22051162228386 3798 9915668 A protesome inhibitor. SGTC_3007 9078383 71.4286 µM -0.77106349868399 0.249810698246389 no 2564 0.220334647386312 3781 6496995 SGTC_2068 5226020 147 µM -0.771526289144938 0.249677028588598 no 2565 0.220197523069002 3841 1810509 SGTC_134 0269-0018 6.916 µM -0.771611505053985 0.249652419471815 no 2566 0.220172279022962 3731 4378915 SGTC_2534 helenine 20.12 µM -0.773565995801535 0.249088344746798 no 2567 0.219593743664739 3796 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1753 st043925 64 µM -0.773596033810265 0.249079680937075 no 2568 0.219584859137859 3838 670181 SGTC_2556 citropten 84.59 µM -0.774093073729241 0.248936343869081 no 2569 0.219437876553103 3826 2775 A potential DNA crosslinker. SGTC_2931 9014674 55.67 µM -0.774568177564378 0.248799373806343 no 2570 0.219297433669383 3809 2996810 SGTC_1688 st021091 57.6 µM -0.774657351795985 0.248773669793797 no 2571 0.219271079114693 3821 3656366 SGTC_1113 artemisinin 1.17947 µM -0.775387464664777 0.248563271713526 no 2572 0.21905537001738 3795 2240 An anti-malaria and mitochondrial poison. SGTC_2490 carminic acid 95.39 µM -0.779636506720726 0.247340700364092 no 2573 0.217802430650637 3719 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3208 9114115 49.47 µM -0.780081920369591 0.247212728473602 no 2574 0.217671328779207 3829 650895 SGTC_2043 5101342 149 µM -0.781341636974123 0.24685099077967 no 2575 0.217300793723368 3819 678451 SGTC_2584 androsterone 48.74 µM -0.782130791270186 0.246624523239674 no 2576 0.217068856310486 3814 2754130 A steroid. SGTC_2537 larixol 68.93 µM -0.783811783454266 0.246142491761014 no 2577 0.216575279304771 3806 6708759 SGTC_305 1682-2595 20.8 µM -0.786006055390392 0.245514036233281 no 2578 0.215931969794166 3856 226033 SGTC_1324 1418-0026 34.4 µM -0.786070978355856 0.245495454960482 no 2579 0.215912952769518 3868 1372513 SGTC_1145 3546-0597 10.2 µM -0.786374484272657 0.245408600093741 no 2580 0.215824063673614 3779 875334 SGTC_904 1141-0088 396 µM -0.786667986319484 0.245324623762018 no 2581 0.215738124629829 3820 1378119 SGTC_2421 5690543 90.72 µM -0.786714054997753 0.245311444068809 no 2582 0.215724637264109 3856 3397993 SGTC_2491 paeonol 100 µM -0.787767143064556 0.245010272092073 no 2583 0.215416461676038 3701 11092 Increases levels of cortical cytochrome oxidase. SGTC_471 1-acyl-paf 4 µM -0.788195673985709 0.244887773776786 no 2584 0.215291129576493 3762 16759367 SGTC_668 1682-0499 62.6 µM -0.789537059084789 0.244504543384579 no 2585 0.214899089378092 3832 682214 SGTC_662 k832-1615 104 µM -0.793111518458079 0.243484908717311 no 2586 0.213856426246856 3869 5878478 SGTC_1103 duloxetine 36.1 µM -0.793856199919856 0.243272773628781 no 2587 0.213639575416445 3921 60835 A selective serotonin reuptake inhibitor. SGTC_1861 st057647 17.4 µM -0.794874563037311 0.242982837491835 no 2588 0.213343236110518 3888 688668 SGTC_1684 st024538 14.6195 µM -0.795013979751238 0.242943158988465 no 2589 0.21330268510167 3806 6732859 SGTC_2961 9083290 32.55 µM -0.797852882674609 0.242135959835513 no 2590 0.212477934367111 3782 17741490 SGTC_1233 0325-0408 14.2 µM -0.800230081128788 0.241461159567096 no 2591 0.211788752158347 3891 12874 SGTC_2992 9074591 71.4286 µM -0.801919843269576 0.240982119274352 no 2592 0.211299663426098 3805 17741321 SGTC_3228 9131799 49.47 µM -0.802464058861553 0.240827946608146 no 2593 0.211142285359777 3834 17015818 SGTC_401 neomycin 50 µM -0.803139720056205 0.240636610971784 no 2594 0.210946991034262 3817 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2459 5811157 9.22 µM -0.803510239400288 0.240531721404312 no 2595 0.210839940435602 3810 2870684 YBR192W RIM2 SGTC_3165 9101544 49.47 µM -0.80508773123972 0.240085431197024 no 2596 0.210384527561736 3857 5002184 SGTC_1230 0170-0365 3.77 µM -0.806080044944388 0.239804925936293 no 2597 0.210098348402996 3926 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2248 tofa 1.1 µM -0.807451598543108 0.239417512431059 no 2598 0.209703174754856 3778 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_428 3448-4153 16.5 µM -0.809806590701656 0.238753111714513 no 2599 0.209025672041826 3823 3834874 SGTC_734 2023-0417 80 µM -0.809827869002281 0.238747113188682 no 2600 0.209019556414834 3851 3935732 SGTC_2797 7859098 81.82 µM -0.810956001439492 0.238429201585846 no 2601 0.208695469174999 3854 972681 SGTC_959 1222-0044 107 µM -0.812012463311896 0.238131697290758 no 2602 0.208392240001127 3809 6083612 SGTC_3064 1327-0027 10 µM -0.8129710797437 0.237861922829327 no 2603 0.208117319754753 3720 16000455 YPR107C YTH1 SGTC_603 3794-0023 45.9 µM -0.815429315020477 0.237170891218905 no 2604 0.207413304935827 3829 3802260 SGTC_3149 9097855 49.47 µM -0.818314408361307 0.236361274808359 no 2605 0.206588840452504 3871 25236625 YMR079W SEC14 SGTC_314 1671-0008 2.74 µM -0.819550264599831 0.236014934217846 no 2606 0.206236268162466 3774 3913060 SGTC_201 4262-0159 12.803 µM -0.820134499411801 0.235851303649349 no 2607 0.206069718477389 3881 1341029 SGTC_1330 1469-0054 61.8 µM -0.821077980234524 0.235587188734202 no 2608 0.205800925846564 3887 7102664 SGTC_3092 9117248 49.47 µM -0.82159892039103 0.235441428406056 no 2609 0.205652601974068 3937 17141857 SGTC_2229 7354935 190 µM -0.823028558097554 0.235041668107472 no 2610 0.205245876748733 3788 318112 SGTC_1650 st011916 45.8 µM -0.824333106463582 0.234677213161965 no 2611 0.204875156190146 3802 242528 SGTC_1476 4112-3294 3.34 µM -0.827014607349846 0.233929057800547 no 2612 0.204114391071907 3907 704369 SGTC_1524 corynanthine 62.1 µM -0.827290812043206 0.23385207011777 no 2613 0.204036125102017 3999 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2198 6589944 200 µM -0.829108159746531 0.233345863506746 no 2614 0.203521603448631 3875 5290268 SGTC_1819 st053448 58.6 µM -0.829851748542469 0.233138918638239 no 2615 0.203311304275499 3796 2857616 SGTC_2733 amorolfine 100 µM -0.829904927500236 0.233124122545586 no 2616 0.203296269359548 3905 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2790 5423970 71.43 µM -0.830412625974763 0.232982890787251 no 2617 0.203152764717501 3942 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1991 st073000 8.92 µM -0.831178659674916 0.232769885205534 no 2618 0.202936354248696 3963 4301969 YIL048W NEO1 SGTC_2816 7982706 58.44 µM -0.831438035610114 0.232697786902471 no 2619 0.202863109747355 3949 2981853 SGTC_1883 5-benzylidenerhodanine 20 µM -0.83170595280834 0.232623327432065 no 2620 0.202787469883338 3891 1273210 SGTC_1108 betulinic acid 729.144 nM -0.832019289095103 0.232536261907367 no 2621 0.202699028431861 3886 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2814 7977482 42.97 µM -0.833845823335073 0.2320290908298 no 2622 0.202183934799316 3962 6456762 SGTC_1979 st071809 45.3 µM -0.833925329170053 0.23200702855731 no 2623 0.202161531476127 3989 4976333 SGTC_1654 st012436 41.8 µM -0.834908317412198 0.231734353210353 no 2624 0.201884665680641 3826 4323132 SGTC_3272 9137413 49.47 µM -0.835645418747871 0.231530002695159 no 2625 0.201677204733162 3822 17614870 SGTC_1511 0906-3109 28.5 µM -0.835749020291807 0.231501288743441 no 2626 0.201648055786476 3910 2882180 SGTC_1715 st032160 10.2275 µM -0.836917689604647 0.231177520747509 no 2627 0.201319418144878 3823 5289825 SGTC_636 0kpi-0074 126 µM -0.837318111749454 0.231066645988857 no 2628 0.201206890645847 3904 616434 SGTC_1802 st050112 57.9 µM -0.837451177056853 0.231029807485328 no 2629 0.201169504695076 3883 4662563 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.838528963517722 0.23073154822074 no 2630 0.200866843982682 3923 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_519 k048-0011 62.8 µM -0.839156894628054 0.230557878063971 no 2631 0.200690636320965 3969 6836379 SGTC_2356 9061756 188.97 µM -0.839255450682411 0.230530626540307 no 2632 0.200662988319859 3911 20104043 SGTC_5 0352-0601 109.883 µM -0.84342788223542 0.229378569148389 no 2633 0.199494591783464 3813 762456 SGTC_2622 2-methoxyxanthone 59.94 µM -0.843499676787483 0.229358774111692 no 2634 0.199474523221893 3910 71034 A hepatoprotective. SGTC_2612 dictamnine 15.46 µM -0.843790654427795 0.229278556199846 no 2635 0.19939319937365 3889 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2448 5185112 27.17 µM -0.843905614135203 0.229246867970739 no 2636 0.199361075376475 3926 5718189 SGTC_2924 9010168 62.78 µM -0.846799245703615 0.228450058152142 no 2637 0.198553514377992 4009 2993929 SGTC_2618 avocadyne 43.43 µM -0.847237232611686 0.228329586871082 no 2638 0.198431452204283 3830 3015189 SGTC_1520 flindersine 88 µM -0.847508333139352 0.228255036718484 no 2639 0.1983559221345 4038 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.847908090771227 0.228145132012616 no 2640 0.198244579159565 3921 368090 SGTC_1928 4'-methoxychalcone 40.3 µM -0.848011009078169 0.228116841669513 no 2641 0.198215919822115 3950 641818 SGTC_1732 st034308 51.822 µM -0.848300302600493 0.228037330785948 no 2642 0.198135374560829 3771 830119 SGTC_2674 ligustilide 100 µM -0.849125639683881 0.227810576689537 no 2643 0.197905692388468 3952 5319022 A signalling regulator. SGTC_1907 st060210 83.7 µM -0.849239644045749 0.227779264972123 no 2644 0.197873978884061 3956 688793 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.850479378704472 0.227438923708718 no 2645 0.197529310239391 3940 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2364 9055074 200 µM -0.851904526048065 0.227048035713539 no 2646 0.19713354228729 3929 6470630 SGTC_113 0099-0221 2.5 µM -0.85239930180935 0.226912417741396 no 2647 0.196996253770383 3860 89219 SGTC_1929 genistein trimethyl ether 50.5 µM -0.854775386970461 0.226261770048978 no 2648 0.196337753291932 3846 136420 SGTC_1162 k048-0130 20.1 µM -0.856560499173961 0.225773643720995 no 2649 0.195843912012841 3879 6797406 SGTC_2457 5731572 11.68 µM -0.858457385281919 0.225255606992715 no 2650 0.19531997599984 3984 2865357 SGTC_2780 5215298 71.43 µM -0.858656335617899 0.225201312990419 no 2651 0.19526507361701 3948 2834131 SGTC_626 0214-0009 33 µM -0.858859967520893 0.225145749055105 no 2652 0.195208889019607 3973 3437874 SGTC_2688 kanamycin b 96.69 µM -0.860349222680247 0.224739620242965 no 2653 0.194798283563097 3994 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1017 4239-0030 168 µM -0.86240792034699 0.224178885747845 no 2654 0.194231541797144 3960 1149593 SGTC_958 1222-0007 33 µM -0.864420236349222 0.223631553060094 no 2655 0.193678540102398 4009 7312461 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.865657692385062 0.22329535330956 no 2656 0.193338953768109 3971 688798 SGTC_1478 0453-0656 35.7 µM -0.868946487775228 0.22240323247251 no 2657 0.192438200361761 3939 5258496 SGTC_3199 9111318 49.47 µM -0.869232442857759 0.222325760289575 no 2658 0.19236000283961 3892 8548020 SGTC_3181 9108277 49.47 µM -0.869427116304464 0.222273027330089 no 2659 0.192306778390735 3857 17097298 SGTC_2949 9072542 2.23 µM -0.869767771730041 0.222180768082127 no 2660 0.192213663595203 3996 16457352 SGTC_2260 7964312 200 µM -0.870113237832762 0.222087228288288 no 2661 0.192119262020682 3991 231951 SGTC_3037 9091026 49.47 µM -0.870962653288236 0.221857332748026 no 2662 0.191887272612635 3911 25236398 YIL048W NEO1 SGTC_2259 7964009 200 µM -0.871704140200201 0.22165675938598 no 2663 0.191684900523615 3979 313134 SGTC_3315 9136395 68.55 µM -0.872999158794119 0.221306703480572 no 2664 0.191331768114879 3914 16876844 SGTC_301 4119-0100 24.5 µM -0.875222275632841 0.220706511616153 no 2665 0.190726487536252 3957 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2092 5303694 80.6725 µM -0.877669566616663 0.220046877091111 no 2666 0.190061532347201 3940 1963699 SGTC_2564 betulinic acid 100 µM -0.878221497723559 0.219898267900084 no 2667 0.189911763884838 3996 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_664 1222-0054 14.9 µM -0.87866652802136 0.219778484044547 no 2668 0.189791056188794 3905 6813991 SGTC_1748 st037455 53.6035 µM -0.879093663998083 0.219663551840223 no 2669 0.189675246438308 3988 580690 SGTC_3227 9130768 49.47 µM -0.87915357551415 0.21964743382644 no 2670 0.189659006053348 3964 17720899 SGTC_34 0469-0683 81.75 µM -0.8800491160135 0.219406587247851 no 2671 0.189416351305726 3913 3690923 SGTC_616 4092-0450 108 µM -0.880227145277213 0.219358726161646 no 2672 0.189368135453967 3957 787165 SGTC_132 0417-1715 25.805 µM -0.881751012903806 0.218949297700077 no 2673 0.188955733933224 3886 6769098 SGTC_2701 st077767 14.721 µM -0.881783294175067 0.218940629216238 no 2674 0.188947003700432 3927 5721188 SGTC_398 bronopol 33.3 µM -0.881995738276865 0.218883586565476 no 2675 0.18888955595208 3845 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2057 5236571 38.335 µM -0.883407862127964 0.218504639308798 no 2676 0.188507972207023 3948 54684039 YBR257W POP4 SGTC_2097 5376186 200 µM -0.88415925585073 0.218303154857868 no 2677 0.188305124689592 3900 742755 SGTC_1439 4092-1168 46 µM -0.884706154883249 0.218156572503777 no 2678 0.188157567613094 3938 2886240 SGTC_3070 9117005 49.47 µM -0.886017081015106 0.217805443184054 no 2679 0.187804161452763 3987 8779016 SGTC_80 0159-0065 512.242 µM -0.886039090218086 0.217799550840499 no 2680 0.187798231600699 3844 1548079 SGTC_2851 9015922 71.43 µM -0.887080213563812 0.217520924486201 no 2681 0.187517858001047 3958 2996893 SGTC_1779 st039427 55 µM -0.887310587752582 0.217459299352002 no 2682 0.187455853404417 3913 1124498 SGTC_566 0958-0068 16.5 µM -0.894052452570907 0.215660317658583 no 2683 0.185646913734107 3857 6815365 SGTC_1426 4048-4480 71.7 µM -0.896424667367644 0.215029380086215 no 2684 0.185012998850938 3947 14224343 SGTC_188 3229-0966 278.469 µM -0.897008914841522 0.214874152540062 no 2685 0.184857080011478 3993 5722370 SGTC_1285 0929-0069 65.5 µM -0.897757929560015 0.21467524355988 no 2686 0.184657309034917 3988 1206237 SGTC_543 3844-1095 191 µM -0.898961657240152 0.214355804894475 no 2687 0.184336542126632 3969 4230703 SGTC_1809 st050081 57.6 µM -0.899490538892542 0.214215540636781 no 2688 0.184195716509902 4048 5036894 SGTC_2822 7994718 71.43 µM -0.899781134326973 0.214138494802015 no 2689 0.184118368009702 3945 1018011 SGTC_3352 9151559 45.5865 µM -0.899984428618528 0.214084604786957 no 2690 0.184064268690722 3965 17159339 SGTC_2673 kobusone 100 µM -0.90022017962933 0.214022120907236 no 2691 0.184001544599961 4014 6710676 An epoxy ketone and protein crosslinker. SGTC_528 3492-0019 172 µM -0.90027262939904 0.214008220967847 no 2692 0.183987591584925 3949 2869262 SGTC_2635 hydroquinidine 100 µM -0.901218627752027 0.213757608091892 no 2693 0.183736044309914 3898 442912 An experimental heart treatment. SGTC_430 0958-0115 16.4 µM -0.9032695145638 0.213214876692701 no 2694 0.183191436009223 3940 6833180 SGTC_1208 2323-2347 50.3 µM -0.90373353550215 0.213092193222645 no 2695 0.183068356121375 3988 5412760 SGTC_2685 mycophenolic acid 18.85 µM -0.906207179957408 0.212438876419835 no 2696 0.182413101708664 3948 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2403 6032726 181.2 µM -0.908035595325432 0.211956724815639 no 2697 0.181929707838382 4036 2881040 SGTC_2135 5326629 150.42 µM -0.908738992664181 0.211771410140877 no 2698 0.181743958213918 3951 5020077 SGTC_568 1193-0097 7.48 µM -0.909172178357825 0.211657331697379 no 2699 0.181629623775151 3848 3646150 SGTC_2282 7944268 200 µM -0.909277308609692 0.211629651315417 no 2700 0.181601882629185 3995 2970414 SGTC_1297 1068-0111 14.1 µM -0.909400767090275 0.211597147888415 no 2701 0.181569308524636 3931 767057 SGTC_3286 9117135 37.221 µM -0.910388894767192 0.211337104728432 no 2702 0.181308726137871 3956 3438150 SGTC_268 camptothecin 39.6153 µM -0.912311074513115 0.210831785962816 no 2703 0.180802493081548 3951 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_131 0141-0277 33.849 µM -0.912565137395982 0.210765048835845 no 2704 0.180735648407883 3968 1547771 SGTC_1573 oleylamine 1.06 µM -0.914670721449323 0.210212432001909 no 2705 0.180182259655028 3986 5356789 An amine of the fatty acid oleic acid. SGTC_3066 9117245 49.47 µM -0.916447322051704 0.209746820474123 no 2706 0.179716162393642 4061 17176980 SGTC_524 r073-0010 27.8 µM -0.917755088016544 0.209404468921444 no 2707 0.179373550008604 3915 2772106 SGTC_54 0159-0055 9 µM -0.920293413893908 0.208740916327294 no 2708 0.178709724930975 3961 3319099 SGTC_3027 9089541 49.47 µM -0.921538924971303 0.208415776652056 no 2709 0.178384564273783 4021 9943819 SGTC_1335 1486-0900 202 µM -0.925141300170141 0.207477062323815 no 2710 0.177446206226521 3986 X1335 SGTC_1339 1486-1321 22.7 µM -0.926124802669589 0.207221214154181 no 2711 0.177190562861635 4008 3469382 SGTC_3013 9080133 71.4286 µM -0.926432447610053 0.207141221780559 no 2712 0.177110644011396 4103 17050193 SGTC_1501 4491-0275 38.4 µM -0.926764381948444 0.207054934282349 no 2713 0.177024440895143 3922 5104718 SGTC_259 usnic acid 108.925 µM -0.927268401935859 0.206923953184101 no 2714 0.176893597952254 4085 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2251 lansoprazole 556 µM -0.928170726039385 0.20668958618353 no 2715 0.176659508471315 3932 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3207 9114163 49.47 µM -0.928309206908033 0.206653631489116 no 2716 0.176623599795495 4053 849233 SGTC_2532 xanthone 78.9 µM -0.928419229249997 0.206625068308781 no 2717 0.17659507382665 4018 7020 An insecticide. SGTC_2006 4011487 200 µM -0.928782815999293 0.206530693258677 no 2718 0.176500825840877 4062 45595294 SGTC_686 1319-0111 510 µM -0.928809795472633 0.206523691300836 no 2719 0.176493833562101 4027 4562600 SGTC_2170 morpholine 200 µM -0.93077213246626 0.20601478495896 no 2720 0.175985723941771 4036 121171 Reacts with secondary amines. SGTC_147 4466-0538 29.23 µM -0.93282939388564 0.20548206057514 no 2721 0.175454031033968 4086 6742687 YHR072W ERG7 SGTC_572 0960-0087 17.7 µM -0.933727852803585 0.205249663005829 no 2722 0.175222146870795 3993 6796365 SGTC_941 3237-0776 460 µM -0.935849825031999 0.204701408804304 no 2723 0.174675256923972 4068 760008 SGTC_845 0330-0138 4.51 µM -0.936528729543628 0.204526184282469 no 2724 0.17450051384592 3976 9039800 SGTC_403 arphamenine a 50 µM -0.936777327668118 0.204462043707927 no 2725 0.174436555012203 3979 5487158 An arginine aminopeptidase inhibitor. SGTC_2867 9039098 71.43 µM -0.938213300780572 0.20409178396418 no 2726 0.174067402175531 3975 6463460 SGTC_2098 5376439 882.5 nM -0.943532157400544 0.202723822418898 no 2727 0.172704387466186 4061 2844116 SGTC_1985 st071382 65.5 µM -0.943708524367809 0.202678556487949 no 2728 0.172659308369163 4006 6123237 SGTC_520 3584-0023 682 µM -0.943865913559634 0.202638166448936 no 2729 0.172619086294091 4033 1340790 SGTC_269 exalamide 29 µM -0.946467228756215 0.201971300372084 no 2730 0.171955164771212 3943 3316 A derivative of salicylamide. SGTC_2933 9026794 32.47 µM -0.949915941033811 0.201089225958661 no 2731 0.171077483102817 3996 17586027 SGTC_3053 9095903 49.47 µM -0.950261419810282 0.201000990625964 no 2732 0.170989718485389 4126 17174018 SGTC_1082 camptothecin 424.86 nM -0.952196276622205 0.200507257325072 no 2733 0.170498724491737 3940 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2493 resveratrol 26.09 µM -0.952670196838887 0.200386434351994 no 2734 0.17037859912515 3905 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3324 9138759 60.749 µM -0.954229403748876 0.19998923313476 no 2735 0.169983766959831 4073 45595710 SGTC_1033 k072-0102 21.3 µM -0.954843244768673 0.199832989746485 no 2736 0.169828487317194 4025 5965931 SGTC_1316 1272-0050 65.9 µM -0.956172580899527 0.199494880307566 no 2737 0.169492525094391 3992 7340392 SGTC_812 4251-0442 148 µM -0.959506459322082 0.198648442427766 no 2738 0.168651833607285 4068 5723007 SGTC_874 0599-0792 117 µM -0.95971975953724 0.198594361487127 no 2739 0.168598137879518 4065 765305 SGTC_1958 st076513 41.9 µM -0.96203352563675 0.198008291307617 no 2740 0.168016381766213 4012 732122 YGL099W LSG1 SGTC_3325 9138760 55.175 µM -0.963493186166224 0.197639101478191 no 2741 0.167650040985817 3979 43844959 SGTC_3152 9099253 49.47 µM -0.965381119205142 0.197162206870316 no 2742 0.167176977393036 3980 25236131 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.966452573519414 0.196891865943131 no 2743 0.166908883849305 4166 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_469 w7 172 µM -0.966987363792341 0.196757015870405 no 2744 0.166775175306962 4105 45115570 A P450 inhibitor. SGTC_1547 harmine 94.2 µM -0.967596629835736 0.196603454534352 no 2745 0.166622930531964 4028 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_4 0960-0234 25.671 µM -0.968535833543916 0.196366876948779 no 2746 0.166388415955125 4050 6821112 SGTC_1453 4237-0541 195 µM -0.968647017125905 0.19633888215849 no 2747 0.166360668072955 4046 739892 SGTC_760 0568-0725 82.9 µM -0.971733907371827 0.195562603848191 no 2748 0.165591471816276 4082 3916171 SGTC_2877 9040724 71.43 µM -0.972320010153209 0.195415423961232 no 2749 0.165445686014872 4052 6463895 SGTC_564 3555-0129 330 µM -0.972416721585805 0.195391144625107 no 2750 0.165421638228003 3902 563260 SGTC_1559 coumarin 343 70.1 µM -0.972724131495426 0.195313981757031 no 2751 0.165345214217777 4097 108770 A hepatotoxic, DNA x-linker. SGTC_1284 0929-0043 16 µM -0.972924468323037 0.195263705236387 no 2752 0.165295421537269 4029 1239883 SGTC_2572 astragaloside iv 100 µM -0.973652290704581 0.195081117156735 no 2753 0.165114606725551 4124 45006101 An anti-inflammatory agent. SGTC_2275 7947463 200 µM -0.974804146506231 0.194792364416598 no 2754 0.164828709951934 4052 1225414 SGTC_1917 st066507 28.5 µM -0.974869927135512 0.194775882063736 no 2755 0.164812392531918 4029 3156428 SGTC_2095 5432005 200 µM -0.977179877764272 0.194197626329831 no 2756 0.164240054042188 4071 783734 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.978767338834813 0.193800840070695 no 2757 0.163847475556438 4113 61125 An anti-inflammatory. SGTC_693 4161-2696 114 µM -0.979920712459861 0.193512864276092 no 2758 0.163562629005351 4098 805759 SGTC_2217 6934799 96.0675 µM -0.980842410786265 0.193282921207565 no 2759 0.163335230175061 4037 675606 SGTC_591 4299-0174 154 µM -0.981230282286526 0.193186205835507 no 2760 0.163239597035337 4072 5509088 SGTC_1291 0993-0025 5.79 µM -0.981453858039487 0.193130470868163 no 2761 0.163184488994708 4079 4353356 SGTC_2645 abamectin 100 µM -0.98145976855932 0.193128997574009 no 2762 0.163183032305035 4024 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_225 nsc-122657 1.016 µM -0.983004735936043 0.19274412440971 no 2763 0.1628025538936 4077 275685 SGTC_1939 st074455 53.6 µM -0.983371956414716 0.19265271358755 no 2764 0.162712203603166 4099 1644229 SGTC_1552 6-methylflavone 10.6 µM -0.986037039814232 0.191990098495853 no 2765 0.162057468576729 3976 689013 SGTC_2960 9079389 5.97 µM -0.986159284173962 0.191959738584917 no 2766 0.162027477836819 4082 16457355 SGTC_2138 5575593 77.673 µM -0.9863092209768 0.191922505149514 no 2767 0.161990698125982 4053 762213 SGTC_1126 isoteolin 1.0172 µM -0.98762655128003 0.191595565843519 no 2768 0.161667788938361 4017 133323 SGTC_597 k018-0003 82.8 µM -0.988181634191984 0.191457905788224 no 2769 0.161531850556058 4132 6786234 SGTC_2394 5221648 200 µM -0.988746570726125 0.191317864287474 no 2770 0.161393575588474 4132 788586 SGTC_229 benomyl 22.8748 µM -0.989347208252627 0.191169041785473 no 2771 0.161246647065986 4093 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1395 3486-0190 4.35 µM -0.992893169051463 0.190291891264178 no 2772 0.160381009526871 4058 6748079 SGTC_127 0180-0333 59.125 µM -0.994254443849168 0.189955815790171 no 2773 0.160049504192101 3954 771601 SGTC_2284 7945075 39.21 µM -0.99438976499015 0.189922427263885 no 2774 0.160016574523957 4090 1245402 SGTC_1645 Cervolide 78 µM -0.995809775098349 0.189572278004847 no 2775 0.159671289939729 4059 23173 A fragrance. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.995874564059002 0.18955631167813 no 2776 0.159655547725915 3908 4000243 SGTC_936 3005-4620 401 µM -0.99763693244746 0.189122318214434 no 2777 0.159227722691545 4139 777207 SGTC_338 4055-0136 114 µM -0.998568676619099 0.188893118274053 no 2778 0.159001840147963 4038 2900563 SGTC_3036 9090181 49.47 µM -1.00099742929926 0.188296473881863 no 2779 0.158414025605366 4121 25236586 SGTC_3124 9127567 49.47 µM -1.00291712345929 0.18782570781786 no 2780 0.157950424991203 4092 17592030 SGTC_1349 flufenamic acid 69 µM -1.00340529496263 0.187706109675858 no 2781 0.157832675189786 4011 3371 A non-steroidal anti-inflammatory. SGTC_1111 tnp00062 510.699 nM -1.00430109098728 0.187486769159058 no 2782 0.157616753976783 4139 676306 SGTC_3017 9080681 49.47 µM -1.00537003989102 0.187225238603617 no 2783 0.157359350366207 4111 16451914 SGTC_3035 9091303 49.47 µM -1.00644771937543 0.186961800494276 no 2784 0.15710012430265 4155 25237002 SGTC_2480 5767542 37.17 µM -1.00697193178273 0.186833740035524 no 2785 0.156974131335374 4049 2867358 SGTC_2486 5283202 22.39 µM -1.01015170428053 0.186058113576623 no 2786 0.156211306878424 4151 1377751 SGTC_3076 9116187 49.47 µM -1.01068887751574 0.185927280882101 no 2787 0.156082681064044 4082 27241210 SGTC_2623 humulene 100 µM -1.01286082063449 0.185398869203535 no 2788 0.155563322358907 4119 6187145 An anti-inflammatory. SGTC_1088 bifonazole 369 nM -1.01325488003877 0.185303098569104 no 2789 0.155469216525796 4054 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1867 st057372 64 µM -1.0143147202419 0.185045671656126 no 2790 0.155216301116661 4063 688837 SGTC_1754 st042065 16.137 µM -1.01456391306026 0.184985176941298 no 2791 0.155156874342336 3921 1126236 YIL048W NEO1 SGTC_1813 st051246 8.6015 µM -1.01583054660761 0.184677875599696 no 2792 0.154855043519543 4021 5291959 SGTC_2015 5119600 184 µM -1.0161669222419 0.184596319977943 no 2793 0.154774952538823 4145 2828786 SGTC_1546 5-methoxyflavanone 78.7 µM -1.01722483702744 0.184339970309634 no 2794 0.154523241620697 4094 147795 SGTC_1333 1482-0047 286 µM -1.01802781035717 0.184145544969345 no 2795 0.15433236995392 4120 3811116 SGTC_628 1636-0253 16 µM -1.01832416180304 0.184073821132947 no 2796 0.15426196480738 4105 4456143 SGTC_893 0958-0369 48.9 µM -1.01996755752131 0.183676397438247 no 2797 0.153871923648324 4044 6819948 SGTC_365 0121-0052 13.6 µM -1.02354946831265 0.182812035354797 no 2798 0.153024061604356 4155 3101739 SGTC_3091 9116372 49.47 µM -1.02359860896921 0.182800194752545 no 2799 0.153012451261939 4189 17169793 SGTC_488 nitrendipine 139 µM -1.02550873239725 0.182340315263128 no 2800 0.15256160360035 4154 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1400 3771-8998 51.5 µM -1.0261584999699 0.182184042766309 no 2801 0.152408439655594 4012 670767 SGTC_3084 9116877 49.47 µM -1.02635115234606 0.182137724957459 no 2802 0.152363047042352 4053 27241325 SGTC_2243 6634756 200 µM -1.02915550948721 0.181464330343661 no 2803 0.151703302542173 4190 885676 SGTC_2764 methyldopa 94.69 µM -1.03046664384118 0.181150030331487 no 2804 0.151395501377616 4126 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1984 st072354 53.1 µM -1.03073558289548 0.181085603481605 no 2805 0.151332416762046 4004 5762938 SGTC_2748 diazoxide 86.69 µM -1.03290951078524 0.18056534598415 no 2806 0.150823123760135 4166 3019 A potassium channel activatior. SGTC_1348 1493-0373 93.8 µM -1.03332893077259 0.180465079711474 no 2807 0.150724996365527 4124 3010129 SGTC_1498 4478-3555 97.6 µM -1.03401959719834 0.180300045568122 no 2808 0.15056350087949 4103 3437919 SGTC_841 0251-0215 91.2 µM -1.0351786403712 0.180023306109255 no 2809 0.150292746003427 4148 3888614 SGTC_402 epigallocatechin gallate 10 µM -1.0396918460029 0.178948251666155 no 2810 0.149241545052105 4080 65064 An antioxidant. SGTC_172 1112-0046 2.638 µM -1.04106860130549 0.17862111169903 no 2811 0.148921855380803 4116 2802135 YIL048W NEO1 SGTC_63 0099-0242 26.702 µM -1.04346004219499 0.178053761456385 no 2812 0.148367638897187 4171 3898502 YLR359W ADE13 SGTC_1711 st032263 62.8 µM -1.0445306146618 0.177800145260012 no 2813 0.148119981296874 4143 3958979 SGTC_838 0109-0203 71.4 µM -1.04507393161242 0.177671521916554 no 2814 0.147994400616267 4142 759422 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.04553733108602 0.177561864419052 no 2815 0.147887348154391 4119 676296 Flavone; oxidizing agent. SGTC_1951 sophoraflavanone G 9.2 µM -1.04578895069523 0.177502339787217 no 2816 0.14782924184666 4102 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_844 0330-0132 15.3 µM -1.04597130675059 0.1774592084266 no 2817 0.147787140068805 4191 2828079 SGTC_2222 6885208 172.143 µM -1.047196512694 0.17716959088988 no 2818 0.147504476677799 4091 609514 SGTC_2478 5763493 32.33 µM -1.04740571480611 0.177120168978894 no 2819 0.147456248546689 4070 1365576 YLR208W SEC13 SGTC_1702 st027038 51 µM -1.04814284279784 0.176946099260955 no 2820 0.14728639993135 4164 5521182 SGTC_815 1582-0027 36.9 µM -1.0490494530076 0.176732155321689 no 2821 0.147077679203184 4170 3128206 SGTC_2644 guaiazulene 100 µM -1.04920167362593 0.176696249994846 no 2822 0.14704265427128 4146 3515 A coloring agent. SGTC_1896 st058441 89 µM -1.04927168000041 0.176679738656992 no 2823 0.147026548157033 4142 688759 SGTC_745 0469-0705 296 µM -1.04977469782729 0.176561128188888 no 2824 0.146910855447963 4210 3486736 SGTC_986 1493-0483 84 µM -1.05088514785167 0.176299464923085 no 2825 0.146655671247739 4096 40079 SGTC_1143 3454-2408 5.08 µM -1.05098943071446 0.176274904618014 no 2826 0.146631722071805 4132 X1143 SGTC_890 0929-0006 47.2 µM -1.05687526737445 0.174892205472392 no 2827 0.145284258718539 4119 1378169 SGTC_1156 4092-0367 4.88 µM -1.05826335565076 0.174567121894896 no 2828 0.144967697137764 4165 1357585 SGTC_1315 1237-0019 3.69 µM -1.05900708037151 0.174393103134577 no 2829 0.144798277589176 4163 825140 SGTC_426 0988-0037 14.6 µM -1.05923345743259 0.174340156690193 no 2830 0.144746735660992 4194 5383008 SGTC_3346 9158254 43.5805 µM -1.06094067680718 0.173941190828031 no 2831 0.144358430931706 4149 17639500 SGTC_955 1216-0110 33 µM -1.06206644507405 0.173678424128428 no 2832 0.144102760930794 4140 3619719 SGTC_2520 obtusaquinone 4.71 µM -1.06271051184599 0.173528205490338 no 2833 0.143956626167343 4213 5967872 SGTC_454 lyso-paf C-16 6.67 µM -1.06345359341402 0.17335499594244 no 2834 0.143788149786795 4177 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1300 1094-0077 113 µM -1.06533781642079 0.17291628417326 no 2835 0.143361542795188 4126 5532636 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.07565294680512 0.170527120696111 no 2836 0.141041249218002 4148 140250 A respiratory chain inhibitor. SGTC_971 1315-0384 26.7 µM -1.07590751890698 0.170468425896017 no 2837 0.140984309449495 4211 6769120 SGTC_2181 6316240 54.2555 µM -1.07714176392561 0.170184038629402 no 2838 0.140708468738158 4192 12779990 SGTC_2325 6158266 200 µM -1.07750047755033 0.170101443055562 no 2839 0.140628368771607 4190 3623240 SGTC_1289 0976-0073 69.1 µM -1.07931605852943 0.169683790773568 no 2840 0.140223428294157 4227 3391136 SGTC_3056 9094900 49.47 µM -1.0808578362552 0.16932964048374 no 2841 0.139880178318628 4151 25236784 SGTC_1630 st005209 31.3 µM -1.08178108961509 0.169117794109892 no 2842 0.139674905631722 4147 3367314 SGTC_1806 st050005 60.3 µM -1.08311661484134 0.168811650625861 no 2843 0.139378332558109 4219 5194765 SGTC_1902 st060212 70.5 µM -1.08322924225193 0.168785849248529 no 2844 0.139353341582361 4178 688944 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.08402808183401 0.168602918914212 no 2845 0.139176173998683 4182 5024745 SGTC_1602 st001878 87.6 µM -1.08574474466511 0.168210242954239 no 2846 0.13879596933576 4173 595405 YLR310C CDC25 SGTC_312 4092-0653 6.84 µM -1.08685598196962 0.167956368274573 no 2847 0.138550231170891 4110 1148278 SGTC_2166 5933061 31.504 µM -1.08703386152074 0.167915752598259 no 2848 0.138510922564865 4325 2877375 SGTC_2288 7946289 167.31 µM -1.08764006032218 0.16777738522346 no 2849 0.13837701916764 4252 1246052 SGTC_1514 1189-1591 158 µM -1.08857121735886 0.167564987831875 no 2850 0.138171507569468 4205 767698 YMR146C TIF34 SGTC_2855 9016525 58.44 µM -1.09010633825324 0.167215204311146 no 2851 0.137833152307578 4138 43811474 SGTC_1321 1326-2144 215 µM -1.09140340477829 0.166920029564709 no 2852 0.137547707452109 4186 3513030 SGTC_490 phenamil 164 µM -1.09166441435201 0.166860671995133 no 2853 0.137490315997547 4150 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1889 st059080 5.18 µM -1.09269113995771 0.166627311034268 no 2854 0.137264715591244 4150 176925 Isolated from Daphnopsis sellowiana. SGTC_1835 st008666 49.2 µM -1.09474318232806 0.166161540816921 no 2855 0.136814582300153 4122 690455 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.09961857433252 0.165058306338284 no 2856 0.13574917279073 4125 4330530 SGTC_2334 9017922 200 µM -1.10127680258741 0.164684155245136 no 2857 0.135388102038575 4249 3163164 SGTC_2652 actinonin 100 µM -1.10293260078882 0.164311101179557 no 2858 0.135028217745004 4206 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_486 niguldipine 82 µM -1.10299996362626 0.164295935829285 no 2859 0.135013590474201 4255 1236 A calcium channel blocker. SGTC_1643 st009866 20.2 µM -1.10348105701047 0.164187653986983 no 2860 0.134909156707988 4142 3156273 YOR207C RET1 SGTC_1448 4255-0083 152 µM -1.10707847667832 0.163379434024494 no 2861 0.134130000138603 4251 5399660 SGTC_2316 5844804 197.44 µM -1.10788758652252 0.1631980106879 no 2862 0.133955183643226 4213 776813 SGTC_2240 6690706 185.951 µM -1.10833375333147 0.163098024579102 no 2863 0.133858851722703 4070 805876 SGTC_71 0417-1750 47.813 µM -1.11020643151801 0.162678791230504 no 2864 0.133455040983019 4210 6811472 SGTC_2438 5259590 200 µM -1.11147281549885 0.162395685607789 no 2865 0.133182442485667 4216 1201127 SGTC_2910 7948405 25.97 µM -1.11223725558646 0.162224947015261 no 2866 0.133018076704576 4122 2971328 SGTC_901 1112-0062 60.1 µM -1.11729659771735 0.16109788467491 no 2867 0.131933764865079 4223 1908457 SGTC_3308 9128332 17.569 µM -1.11810475374391 0.16091832732991 no 2868 0.131761128194605 4217 17332805 YDL196W YDL196W SGTC_852 0418-0143 439 µM -1.11882337364456 0.160758773031535 no 2869 0.131607749021796 4211 5369229 SGTC_3174 9107204 49.47 µM -1.12262045489707 0.15991742728681 no 2870 0.130799362126146 4241 3938802 SGTC_1052 3253-3998 198 µM -1.12610548384756 0.159147764416464 no 2871 0.130060436564508 4152 5450317 SGTC_271 rotenone 740 µM -1.12752363561543 0.158835263701915 no 2872 0.129760576565942 4277 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_746 1095-0025 46.6 µM -1.12835029070076 0.158653289536317 no 2873 0.129586006162425 4233 6749286 SGTC_1287 0971-0001 34.6 µM -1.12939691725188 0.158423088544358 no 2874 0.129365216358606 4212 4665869 SGTC_657 3534-0529 86.7 µM -1.13399190618219 0.157415034410356 no 2875 0.128398971558152 4272 1049549 SGTC_721 1187-1332 279 µM -1.13540608444081 0.157105640596372 no 2876 0.128102605761396 4182 25730 SGTC_2012 4023501 200 µM -1.1394822393838 0.15621609888034 no 2877 0.127251035964103 4253 3477460 SGTC_646 4092-0839 27.3 µM -1.14143929890229 0.155790189950014 no 2878 0.126843579328281 4256 877796 SGTC_383 2324-0395 7.37 µM -1.14233408815603 0.155595714975324 no 2879 0.126657588551298 4228 3146421 SGTC_224 benfluorex 43.875 µM -1.14257552946681 0.155543267167301 no 2880 0.126607435146897 4254 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_571 k831-0106 44.2 µM -1.14373309829053 0.155291972844297 no 2881 0.126367171263282 4103 4783639 SGTC_927 2425-1185 123 µM -1.15088195035523 0.153745982890091 no 2882 0.124890402170416 4176 730375 SGTC_2636 apigenin dimethyl ether 100 µM -1.15231026753491 0.153438324560338 no 2883 0.124596799636175 4237 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2871 9038510 12.99 µM -1.15680958148276 0.152471843331353 no 2884 0.12367508317894 4221 4945164 SGTC_35 0133-0054 64.071 µM -1.15784605250144 0.152249776527692 no 2885 0.123463433041841 4247 99677 SGTC_3312 9133330 71.43 µM -1.15882720478037 0.152039759854472 no 2886 0.123263313022421 4283 17617324 SGTC_813 k007-0158 173 µM -1.16114603334955 0.151544177234283 no 2887 0.122791258507762 4245 6523916 SGTC_2742 clothiapine 36.27 µM -1.16216160845892 0.151327465937263 no 2888 0.122584912992311 4273 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1496 4469-0713 57.4 µM -1.16295476520625 0.151158359408586 no 2889 0.122423927931136 4226 746691 SGTC_1221 2958-7315 257 µM -1.16956183141995 0.149754573925243 no 2890 0.121088672473694 4298 4562705 SGTC_2294 7971431 200 µM -1.16971902638807 0.149721281396864 no 2891 0.121057029409911 4249 5741572 SGTC_1526 st051518 75 µM -1.17189167526531 0.14926163900651 no 2892 0.120620274872574 4243 673993 SGTC_2713 st079149 53.4 µM -1.17448208918359 0.148714847502554 no 2893 0.120100990946325 4280 3103253 SGTC_386 1509-0011 3.07 µM -1.17857959219728 0.147852672740432 no 2894 0.119282810937444 4257 3107280 SGTC_153 4077-0274 519.67 µM -1.18063629971895 0.147421175257873 no 2895 0.118873618408822 4318 3121976 SGTC_724 3910-0327 137 µM -1.18295003002124 0.146936763910235 no 2896 0.118414476026303 4316 2885483 SGTC_1796 st049173 110.4 µM -1.18303630107262 0.146918722544374 no 2897 0.118397380459952 4238 94134 SGTC_933 2914-0560 114 µM -1.18507281679977 0.146493269281947 no 2898 0.117994328862678 4286 463887 SGTC_1194 1488-0194 225 µM -1.18546086842464 0.14641229440997 no 2899 0.117917638878935 4230 1391452 SGTC_784 4579-0127 173 µM -1.18688228264313 0.146115944057416 no 2900 0.117637028380485 4297 1948547 SGTC_2180 6301957 200 µM -1.18743482405612 0.146000853647529 no 2901 0.117528075320969 4297 845462 SGTC_109 0132-0036 33.701 µM -1.18755087497075 0.145976688816887 no 2902 0.117505200864563 4085 67274 A color developer. SGTC_788 1182-0090 188 µM -1.19021640793348 0.145422394964461 no 2903 0.116980672904023 4287 5715185 SGTC_934 2950-0684 338 µM -1.19134634220677 0.145187854519894 no 2904 0.11675882409882 4313 1121253 SGTC_761 k216-0224 480 µM -1.19364408100674 0.144711698394351 no 2905 0.116308611491154 4320 1340404 SGTC_2913 7966556 36.57 µM -1.19767357520453 0.14387921593175 no 2906 0.115522060244172 4168 2976516 SGTC_1794 st048918 76.9 µM -1.19812104462857 0.143786969671091 no 2907 0.11543494858826 4207 672303 SGTC_981 1488-1094 54.9 µM -1.1983851614111 0.143732540468772 no 2908 0.115383553244398 4253 3449522 SGTC_1791 st048313 56.1 µM -1.19941821703807 0.143519781852565 no 2909 0.115182683798602 4289 1204976 SGTC_418 lividomycin a 100 µM -1.20079808670656 0.143235928398191 no 2910 0.11491476711658 4296 72394 An antibiotic. SGTC_156 3474-0145 5.642 µM -1.20192366383855 0.14300466652821 no 2911 0.114696552577476 4167 2265471 SGTC_284 0988-0104 32.6 µM -1.20208735438106 0.14297105557921 no 2912 0.114664842626113 4256 4666532 SGTC_1 0258-0098 57.368 µM -1.20494339002675 0.14238547840186 no 2913 0.114112578291887 4235 6790032 YDR047W HEM12 SGTC_1323 1348-1351 11.2 µM -1.20594569904728 0.142180358665785 no 2914 0.113919214209587 4272 6989654 SGTC_1184 1269-1718 139 µM -1.20824937998463 0.141709675114066 no 2915 0.113475676483278 4332 5403821 SGTC_1347 1493-0251 600 nM -1.20940187121415 0.141474596902226 no 2916 0.113254245055448 4337 3986378 SGTC_1504 k297-0033 30 µM -1.21023420364455 0.141304987180676 no 2917 0.113094518463201 4170 4388117 SGTC_2253 7938677 135.83 µM -1.21042732989456 0.141265652314764 no 2918 0.113057480059759 4350 2301972 SGTC_2687 chenodiol 100 µM -1.21183751658171 0.140978658431873 no 2919 0.112787292060835 4358 5702181 A cholesterol synthesis inhibitor. SGTC_2778 tioconazole 65.09 nM -1.21271601262325 0.140800071527726 no 2920 0.112619207799945 4176 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_53 0973-0023 39.979 µM -1.21854277018585 0.139619452979147 no 2921 0.111508890960604 4190 674768 SGTC_358 0075-0058 9.45 µM -1.21990151480752 0.139345114655233 no 2922 0.111251105763707 4215 1069125 SGTC_645 0845-0943 5.41 µM -1.22458260798917 0.138402784613647 no 2923 0.110366262048128 4316 1885106 SGTC_2387 9077560 195.08 µM -1.22493361187577 0.138332301043024 no 2924 0.110300117494614 4313 5303272 SGTC_1174 0739-0097 51.1 µM -1.22559767940616 0.138199019460072 no 2925 0.110175055775105 4344 728447 SGTC_2802 7925815 54.55 µM -1.22721017758272 0.137875747747086 no 2926 0.109871802562603 4272 1262923 SGTC_3150 9097574 49.47 µM -1.22764284087755 0.137789095777072 no 2927 0.109790536103978 4348 17217476 SGTC_2428 5615643 7.78 µM -1.22923732943522 0.137470079216904 no 2928 0.109491418353669 4312 2253075 SGTC_756 0508-1999 28.3 µM -1.229239681297 0.137469609041996 no 2929 0.109490977589329 4325 6753853 SGTC_1990 st072050 59.8 µM -1.23009236283662 0.137299216673159 no 2930 0.109331259813672 4304 17233948 SGTC_1658 st012944 20 µM -1.23187135156611 0.136944183781514 no 2931 0.10899857227715 4157 24207260 SGTC_248 streptozotocin 5.23457 mM -1.23331581193227 0.136656374644611 no 2932 0.108728980433563 4342 5300 DNA alkylating agent. SGTC_2595 hexamethylquercetagetin 100 µM -1.23490218935355 0.13634076534653 no 2933 0.108433454275783 4323 386331 SGTC_593 1203-0218 61.7 µM -1.23706852523387 0.135910579537949 no 2934 0.108030821808817 4346 3666956 SGTC_549 1661-1316 519 µM -1.23839864629776 0.135646908252537 no 2935 0.107784141171449 4350 2857282 SGTC_2703 st077852 53.4 µM -1.24357856003483 0.134623429354487 no 2936 0.106827355511085 4347 6281836 SGTC_2752 diclazuril 33.15 µM -1.24402040407495 0.134536373103014 no 2937 0.106746026738126 4255 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1131 3454-3128 32.3 µM -1.24581080391838 0.13418400736287 no 2938 0.10641693111386 4336 710982 SGTC_873 0591-4978 488 µM -1.24607113534391 0.134132824787308 no 2939 0.106369140342585 4379 3305145 SGTC_2147 5545932 89.7195 µM -1.25180638357242 0.133008645333242 no 2940 0.105320211750862 4361 797404 SGTC_1646 st011709 75.6 µM -1.25540940538199 0.132305734901843 no 2941 0.10466508838463 4287 5757843 SGTC_2362 9071156 126 µM -1.25560253341004 0.132268130156124 no 2942 0.104630056200874 4341 653133 SGTC_2846 9008642 19.48 µM -1.26127965552296 0.131166005147123 no 2943 0.103604054206519 4360 2992898 SGTC_2991 9074669 71.4286 µM -1.26489105997136 0.130468217123122 no 2944 0.102955191272067 4320 17333109 SGTC_79 0052-0007 94.094 µM -1.26729933564506 0.130004324454183 no 2945 0.102524138997317 4338 2801472 SGTC_2553 4-methylesculetin 85.09 µM -1.26764425455041 0.12993797824073 no 2946 0.102462510250761 4366 5319502 SGTC_1356 1502-0781 85.8 µM -1.27581893175821 0.128372411907008 no 2947 0.101009766814527 4344 567702 SGTC_2038 4100038 30.985 µM -1.27865980927229 0.127831422586367 no 2948 0.100508439233598 4316 3596803 SGTC_553 k007-0256 45.7 µM -1.28009409952643 0.127558892900825 no 2949 0.100256021791043 4401 6287000 SGTC_2917 7979103 53.79 µM -1.2802586465493 0.127527653149255 no 2950 0.100227093151931 4365 2980565 SGTC_835 0312-0010 67.2 µM -1.28083906882661 0.127417500698659 no 2951 0.100125099080305 4364 1626196 SGTC_659 k018-0002 107 µM -1.28092793696689 0.127400641159618 no 2952 0.100109489514887 4321 6797879 YHR007C ERG11 SGTC_939 1165-0479 45.3 µM -1.28330151965007 0.126950913099569 no 2953 0.0996932302483443 4338 1377347 SGTC_2189 6047310 154.431 µM -1.28601178767369 0.126438745184083 no 2954 0.0992194739184162 4324 711535 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.29016317481543 0.125657038813531 no 2955 0.0984970045164572 4376 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2882 9058044 58.44 µM -1.29363511160627 0.12500586720477 no 2956 0.0978957442028334 4380 18076804 SGTC_190 3970-0790 3.722 µM -1.30064982608391 0.123697438715357 no 2957 0.0966891718360429 4336 2832352 SGTC_792 4534-1957 155 µM -1.30207724812082 0.123432365463975 no 2958 0.0964449899645196 4337 1717904 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.30494096636348 0.122901771557414 no 2959 0.0959564751226085 4376 5282362 SGTC_3257 9139206 32.98 µM -1.30708798169532 0.122505019819793 no 2960 0.0955914162490294 4380 4910041 SGTC_2922 7999257 32.47 µM -1.30799872959287 0.122336992452364 no 2961 0.0954368700916037 4342 2988377 SGTC_384 k007-0144 5.16 µM -1.30838650268485 0.122265499831591 no 2962 0.0953711241552357 4303 6824886 SGTC_2281 7943571 200 µM -1.30983672034192 0.121998387297153 no 2963 0.0951255389743313 4459 1244024 SGTC_96 0929-0093 37.281 µM -1.30998904673667 0.121970354423165 no 2964 0.0950997705175449 4380 6991579 SGTC_1625 st003711 30.1 µM -1.31074663758388 0.121831000953132 no 2965 0.094971688220425 4410 24207034 YER133W GLC7 SGTC_3192 9110362 49.47 µM -1.31461971170189 0.121120324109817 no 2966 0.0943188710038592 4373 16649480 SGTC_3243 9134147 49.47 µM -1.31570016132719 0.120922591861668 no 2967 0.0941373500262419 4468 24282180 SGTC_2874 9043904 71.43 µM -1.31594108053591 0.120878532413701 no 2968 0.0940969095504661 4314 4463428 SGTC_1385 3091-4834 14.1 µM -1.3161415378155 0.120841881279051 no 2969 0.0940632707472264 4366 4072814 SGTC_1112 tnp00069 1.16933 µM -1.31664427917061 0.120749995645849 no 2970 0.0939789445850418 4376 145826 SGTC_1236 0330-0013 258 µM -1.32075075496277 0.120001299617336 no 2971 0.0932922422723809 4391 4617066 SGTC_2694 st077685 81.9 µM -1.32430029024276 0.119356786902613 no 2972 0.0927016670896906 4305 2838096 SGTC_3339 9145883 14.936 µM -1.32678144992896 0.118907719218903 no 2973 0.092290494230884 4298 2030670 SGTC_2452 5863136 48.41 µM -1.32739298424719 0.118797220512646 no 2974 0.0921893596298902 4318 2184096 SGTC_545 4218-0007 221 µM -1.32825794034799 0.11864105466717 no 2975 0.0920464546380754 4374 2840508 SGTC_1214 0358-0031 63.7 µM -1.33070905624984 0.11819929940858 no 2976 0.0916423809963722 4427 4301366 SGTC_33 0986-0033 35.816 µM -1.33130521090956 0.118092032805023 no 2977 0.091544302159517 4344 2848082 SGTC_1880 MG-132 525 µM -1.33201772364363 0.117963920136313 no 2978 0.0914271822666122 4342 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_946 3434-1334 87.4 µM -1.33238680870107 0.11789759582163 no 2979 0.0913665572782298 4368 4047976 SGTC_889 0919-1524 82.7 µM -1.33650176126384 0.117159928270532 no 2980 0.0906926626047234 4403 3905452 SGTC_287 k060-0039 29.6 µM -1.33753717454338 0.116974830761544 no 2981 0.0905236781202091 4418 5861974 SGTC_1435 4092-0789 56.7 µM -1.33820386293736 0.116855758750307 no 2982 0.090414995110197 4376 2248285 SGTC_2059 5238311 157 µM -1.34068724104876 0.1164129781008 no 2983 0.0900110093899325 4352 703021 SGTC_385 1494-0393 12.4 µM -1.34414449752844 0.115798540938883 no 2984 0.0894508326663525 4365 3090647 SGTC_2244 6635614 200 µM -1.34455284400112 0.115726120366377 no 2985 0.0893848401854452 4332 836499 SGTC_2326 6164455 177.58 µM -1.34686742694784 0.115316235155327 no 2986 0.089011466946052 4352 2888790 SGTC_2139 5578692 56.4705 µM -1.35107250768891 0.114574207625317 no 2987 0.0883361035856021 4381 650991 YMR113W FOL3 SGTC_738 1315-0003 72.4 µM -1.35450465285543 0.11397109574032 no 2988 0.0877877149852409 4425 6251474 SGTC_2755 lomerizine 42.69 µM -1.35501442887583 0.113881708910764 no 2989 0.0877064799824921 4336 3949 A calcium channel blocker. SGTC_2970 9090938 41.86 µM -1.35646273671896 0.113628027551071 no 2990 0.0874759919049448 4458 17217104 SGTC_3310 9130229 44.1445 µM -1.35720135766204 0.113498808101205 no 2991 0.0873586197449904 4427 7761258 SGTC_2885 9057732 51.95 µM -1.35939363273198 0.113115893518574 no 2992 0.087010943845827 4437 6471414 SGTC_1788 fluconazole 20 µM -1.36100962184559 0.112834226947135 no 2993 0.0867553243924471 4420 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.36345977212041 0.112408121979327 no 2994 0.0863688271882655 4413 551469 SGTC_1419 3993-2473 62.6 µM -1.37106064376799 0.11109357511268 no 2995 0.0851780261135261 4483 704026 SGTC_1286 0929-0070 131 µM -1.37247111774091 0.110850854021305 no 2996 0.0849584120383964 4483 1420408 SGTC_2940 9060638 45.86 µM -1.37392143932156 0.110601672188163 no 2997 0.0847330364876263 4413 4027022 SGTC_909 3448-9333 149 µM -1.37611615009742 0.110225359647192 no 2998 0.0843928381292462 4348 3344074 SGTC_108 0509-0257 621.132 µM -1.38099732826846 0.109391710789239 no 2999 0.0836398910711853 4373 536624 SGTC_2050 5263056 171 µM -1.38476822525275 0.108750792953054 no 3000 0.0830616748989061 4409 763468 YGL055W OLE1 SGTC_2704 st078022 71.1 µM -1.38772369025216 0.108250360285456 no 3001 0.0826105996600983 4451 54697681 SGTC_3298 9116858 71.43 µM -1.38857930100282 0.1081057942632 no 3002 0.0824803575960908 4491 2506942 SGTC_1635 st007035 42.4 µM -1.38879142095972 0.108069975482304 no 3003 0.0824480923750643 4389 3716403 SGTC_2518 prenyletin 46.28 µM -1.39117844858791 0.107667488663599 no 3004 0.0820856603899789 4431 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3213 9129884 49.47 µM -1.39150559689487 0.10761241106517 no 3005 0.082036081815958 4412 17190742 SGTC_1793 st048256 72.231 µM -1.39248555292626 0.107447550426534 no 3006 0.081887706739422 4388 672022 SGTC_1686 st019653 115.5 µM -1.39442944615454 0.107121062897478 no 3007 0.0815939806180104 4432 97252 SGTC_673 1082-0474 110 µM -1.39598735834473 0.106859919921267 no 3008 0.0813591510088118 4420 3098046 SGTC_186 3455-3465 67.277 µM -1.39666521377072 0.106746438819279 no 3009 0.0812571347739825 4433 755278 SGTC_1311 1190-0148 100 µM -1.40086011312268 0.106046096583625 no 3010 0.0806279541978013 4470 1961333 SGTC_2514 salinomycin 42.74 µM -1.40255235250241 0.1057645174885 no 3011 0.0803751843435082 4474 23682228 A polyether potassium ionophore. SGTC_266 formosanin C 406 nM -1.4036489590421 0.10558233718023 no 3012 0.0802117042032305 4291 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2640 pentamidine 10.38 µM -1.40713251548121 0.105005116180655 no 3013 0.0796940489875568 4401 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1760 st045453 10.4495 µM -1.40874030906304 0.104739478566564 no 3014 0.0794559855520064 4472 3323419 YIL048W NEO1 SGTC_257 daunorubicin 18.5 µM -1.40874355565584 0.10473894266142 no 3015 0.0794555053792691 4468 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_180 1486-1293 102.781 µM -1.41193639261983 0.10421287164264 no 3016 0.0789843454464307 4384 4140536 SGTC_825 1988-2224 89.6 µM -1.41287317323192 0.104058886068583 no 3017 0.078846509114069 4420 1180859 SGTC_1563 conessine 56.1 µM -1.41662159553374 0.10344438088486 no 3018 0.0782967955866804 4518 441082 An anti-amoebic, histamine inhibitor. SGTC_1282 0886-0010 32.4 µM -1.41669051867962 0.103433106543875 no 3019 0.0782867151525431 4471 2836211 YNL267W PIK1 SGTC_32 0928-0142 34.1 µM -1.41804290619411 0.103212065520565 no 3020 0.0780891192234004 4441 2244242 SGTC_2543 pimpinellin 60.67 µM -1.41816812237984 0.103191616919764 no 3021 0.0780708431713453 4296 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1226 3909-7979 35.4 µM -1.41961887193377 0.102954914743543 no 3022 0.0778593341158582 4430 6615510 SGTC_216 k038-0035 28.382 µM -1.41988346031801 0.102911787452234 no 3023 0.0778208059276643 4377 4444231 YPR107C YTH1 SGTC_1006 4099-6547 255 µM -1.42065961076719 0.102785352459164 no 3024 0.0777078698183866 4451 3146833 SGTC_181 1447-1644 8.07 µM -1.42309344762191 0.102389612200325 no 3025 0.0773545337883825 4407 534600 SGTC_1851 st056236 18.9 µM -1.42442946917234 0.102172847596645 no 3026 0.0771610943115136 4434 5393171 SGTC_119 0121-0043 24.815 µM -1.42720649985599 0.101723353050554 no 3027 0.0767601907623151 4467 1092378 SGTC_331 k048-0133 24.5 µM -1.42744701469837 0.101684490791134 no 3028 0.0767255437174885 4425 6813582 SGTC_1834 st055981 52.8 µM -1.42985736430432 0.10129562466065 no 3029 0.0763789804957191 4434 471719 YDL150W RPC53 SGTC_374 0880-0231 82.3 µM -1.43073588255283 0.101154161459789 no 3030 0.076252962595173 4323 6833587 SGTC_2082 5219693 150 µM -1.432335501548 0.100896953012753 no 3031 0.0760239137882042 4415 2834649 SGTC_691 1548-0686 185 µM -1.4337514383391 0.10066967761549 no 3032 0.0758216037434633 4431 46495133 SGTC_750 4073-0104 132 µM -1.43395394869487 0.100637202740372 no 3033 0.0757927024682238 4147 22330957 SGTC_3105 9121040 49.47 µM -1.43398582293952 0.100632092033099 no 3034 0.0757881542982143 4413 41448907 SGTC_1177 0983-0204 23.6 µM -1.43511828556137 0.100450636132648 no 3035 0.0756266968584643 4476 766818 SGTC_2833 9001315 45.46 µM -1.43604061583329 0.100303026494646 no 3036 0.0754953921426922 4404 2989378 SGTC_1420 4'-methoxyflavone 42 µM -1.43676044894762 0.100187934517571 no 3037 0.0753930360698409 4444 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2419 paclitaxel 166.5 µM -1.4368518327101 0.100173330338386 no 3038 0.0753800494013136 4404 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1367 1812-0510 76.9 µM -1.43840473912588 0.0999253955288274 no 3039 0.0751596243815136 4516 1142582 YDR527W RBA50 SGTC_1798 st045719 60.953 µM -1.44668974994614 0.0986101937276554 no 3040 0.073991918266532 4420 3980186 SGTC_75 0159-0059 199.013 µM -1.44681800437483 0.0985899340904372 no 3041 0.0739739514039746 4524 5377270 SGTC_988 1497-1057 103 µM -1.44885468543659 0.0982686192196484 no 3042 0.0736890841070842 4453 3533044 SGTC_43 0570-0105 72.5 µM -1.44919255229347 0.0982153902655037 no 3043 0.0736419084202068 4433 1114046 YDL195W SEC31 SGTC_2132 5317594 122.667 µM -1.4533124587056 0.097568021214585 no 3044 0.0730685098509154 4404 794577 SGTC_138 0850-0259 40.9225 µM -1.45355787847481 0.0975295569090545 no 3045 0.0730344610552256 4404 6813004 SGTC_647 0140-0236 81 µM -1.4551237788553 0.0972843973037219 no 3046 0.0728174986223211 4481 990837 SGTC_1510 1123-0200 71.5 µM -1.45559003572794 0.0972114868933637 no 3047 0.0727529921010141 4464 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2925 9010536 32.5 µM -1.45587573965981 0.0971668300696531 no 3048 0.0727134866595176 4384 2994177 SGTC_302 1094-0063 18.9 µM -1.45633465328035 0.0970951312986708 no 3049 0.072650065198448 4451 5440289 SGTC_1944 st076371 56.9 µM -1.4580845276409 0.0968220944638589 no 3050 0.072408622786399 4430 24208455 SGTC_1679 SEC14.276 6.7 µM -1.45840238756164 0.0967725586311667 no 3051 0.0723648314821025 4448 1005053 YMR079W SEC14 SGTC_780 0109-0199 192 µM -1.46120849038316 0.0963360579523528 no 3052 0.071979116857516 4504 610414 SGTC_317 4495-0002 170 µM -1.46301404471406 0.0960559627407004 no 3053 0.0717317679615666 4486 15991618 SGTC_2979 9012552 45.46 µM -1.4663343682307 0.0955424456171605 no 3054 0.0712786084304699 4484 17100905 SGTC_2297 7971671 152.32 µM -1.4678974889775 0.0953013959384095 no 3055 0.0710660351898333 4471 909016 SGTC_637 1181-0519 7.26 µM -1.47218871602441 0.0946419459339767 no 3056 0.0704849618426045 4485 6252091 YGR060W ERG25 SGTC_2984 9022109 38.96 µM -1.47646316873681 0.0939884235943318 no 3057 0.0699097978407372 4489 6459207 SGTC_801 0866-0028 10.1 µM -1.48055788826953 0.0933655094652389 no 3058 0.0693622120703507 4514 6849771 SGTC_3256 9138902 49.47 µM -1.48329458853952 0.0929508893149232 no 3059 0.0689980797406715 4595 17228773 SGTC_133 0724-0033 378.92 µM -1.48582218471631 0.092569159798939 no 3060 0.0686630802578741 4374 280309 SGTC_2502 avocadyne acetate 18.59 µM -1.48824150813805 0.0922048695845502 no 3061 0.0683436071476184 4428 3952079 SGTC_83 0170-0301 39.027 µM -1.49244986297783 0.0915737257546573 no 3062 0.0677906257772928 4512 3089716 SGTC_2897 9048598 12.99 µM -1.49397573141187 0.0913456777624076 no 3063 0.0675909812644725 4474 6467404 SGTC_907 3448-6986 75.5 µM -1.49457410441885 0.0912563632054418 no 3064 0.0675128143056344 4504 590582 SGTC_3074 9116018 49.47 µM -1.49875600649337 0.0906339695693752 no 3065 0.0669684706920775 4540 17027303 SGTC_1492 4158-0558 28.5 µM -1.50133929853111 0.0902510750588588 no 3066 0.0666339127171684 4500 3967268 SGTC_1480 1070-0044 41.2 µM -1.50291285740195 0.0900184323569363 no 3067 0.0664307585065013 4535 3124987 SGTC_1008 4106-0037 6 µM -1.50504280580973 0.0897042404717913 no 3068 0.0661565359345409 4519 2905394 SGTC_2347 9049783 174.81 µM -1.50532220422821 0.0896630865542432 no 3069 0.0661206296236596 4472 6467988 YPL169C MEX67 SGTC_2727 riluzole 51.77 µM -1.51089985064472 0.0888444633758447 no 3070 0.0654069844662109 4543 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_327 1273-0057 3.96 µM -1.51123983216649 0.0887947453095977 no 3071 0.0653636786604371 4405 3108138 SGTC_255 tunicamycin 200.472 nM -1.51934410880056 0.0876157208175006 no 3072 0.0643379512416906 4427 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_868 0527-0199 213 µM -1.52372230397914 0.0869836529936243 no 3073 0.0637890477005825 4490 2849450 SGTC_1949 st076024 69.1 µM -1.52403704597534 0.0869383461404514 no 3074 0.0637497286132439 4471 2921930 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.52508857266586 0.0867871075661923 no 3075 0.063618503532018 4583 688664 SGTC_970 1315-0089 19.5 µM -1.53075324768172 0.0859757515819704 no 3076 0.062915194136768 4480 6811083 YLR033W RSC58 SGTC_695 3505-6186 243 µM -1.5322707536721 0.0857593649397052 no 3077 0.0627278175242448 4506 1819379 SGTC_276 colchicine 750 µM -1.5351547617464 0.0853492478908434 no 3078 0.0623729087359958 4542 2833 A microtubule depolymerizer. SGTC_3041 9091929 49.47 µM -1.5364460204617 0.0851661028063823 no 3079 0.0622145135780412 4494 25236887 SGTC_2372 9071633 200 µM -1.54147483829865 0.0844556489423069 no 3080 0.0616006310913442 4559 21321366 SGTC_1262 0737-0114 49.6 µM -1.54224292357402 0.084347529114947 no 3081 0.061507286506522 4524 765919 SGTC_573 3702-0553 84.7 µM -1.54528483987822 0.0839203526696481 no 3082 0.0611386903942631 4456 1222756 SGTC_965 1291-5240 308 µM -1.54716963006346 0.0836564878985808 no 3083 0.0609111735838241 4515 2834598 SGTC_1060 3448-7350 82 µM -1.54890585327404 0.0834139740496559 no 3084 0.0607021768379519 4454 570178 SGTC_3311 9131146 2.8755 µM -1.54906006741704 0.0833924591569842 no 3085 0.0606836405645301 4468 4900406 YPR165W RHO1 SGTC_130 0136-0219 337.655 µM -1.55144966208896 0.0830596122717889 no 3086 0.060396980873969 4410 234244 SGTC_1125 tnp00248 1.32998 µM -1.55468749453441 0.0826102096664512 no 3087 0.0600102571812582 4547 24207736 SGTC_1003 4049-0218 100 µM -1.55928327152146 0.0819754737457865 no 3088 0.0594646746474505 4532 295161 SGTC_3182 9108849 49.47 µM -1.56217825433527 0.0815775301387962 no 3089 0.0591230009554927 4541 17133045 SGTC_3161 9100388 49.47 µM -1.56246927213228 0.0815376076180808 no 3090 0.0590887395976807 4604 25236368 SGTC_2185 6113692 200 µM -1.56299802800621 0.0814651093210789 no 3091 0.0590265293280667 4522 874150 SGTC_749 1000-0129 128 µM -1.57249835336548 0.0801707795268685 no 3092 0.0579175103723302 4549 708470 SGTC_155 k072-0202 43.6 µM -1.57299938268809 0.0801029530036002 no 3093 0.0578594805759802 4514 5857737 SGTC_2016 5121758 140 µM -1.57818698488027 0.0794032324587527 no 3094 0.0572613296822561 4461 2795203 SGTC_2191 5911152 200 µM -1.57830972592537 0.0793867329539547 no 3095 0.0572472363140922 4559 2875902 SGTC_3046 9092212 49.47 µM -1.57877315241364 0.0793244600931388 no 3096 0.0571940493828078 4604 25236637 SGTC_829 1635-0120 117 µM -1.58427429483558 0.0785880671902146 no 3097 0.0565656563756714 4517 285054 SGTC_682 0kpi-0099 17 µM -1.58819377217821 0.0780665680590567 no 3098 0.0561212644779391 4544 1714895 YML126C ERG13 SGTC_666 0272-0154 136 µM -1.5897064567383 0.0778660041182533 no 3099 0.0559504938012082 4542 6870312 SGTC_1114 scopoletin 1.73284 µM -1.59129834658573 0.0776553610510768 no 3100 0.0557712243736351 4570 5280460 A coumarin with genotoxic properties. SGTC_2007 4011539 71.82 µM -1.6091857230587 0.0753181106277263 no 3101 0.0537878686343195 4508 45595301 SGTC_2712 st079126 47.7 µM -1.61208787457186 0.0749440111654589 no 3102 0.053471409467211 4551 3152970 SGTC_2228 7354201 200 µM -1.61589376627597 0.0744555660135374 no 3103 0.0530586418168601 4647 753451 SGTC_27 0485-0001 32.618 µM -1.62284054992589 0.073570292878185 no 3104 0.0523117474391768 4556 2054479 SGTC_369 0957-0393 4.5 µM -1.62434115835569 0.0733801220691011 no 3105 0.0521515088456233 4545 6997992 SGTC_2126 5251174 33.877 µM -1.62490868772669 0.0733082976309655 no 3106 0.0520910083884506 4532 790722 SGTC_2411 st077133 39.94 µM -1.6287892833803 0.0728186239156537 no 3107 0.0516788170608638 4527 1403142 YNL221C POP1 SGTC_530 4358-1714 28 µM -1.62970675604506 0.0727032192946488 no 3108 0.0515817444022222 4541 1564641 SGTC_215 1287-0124 461.5 µM -1.63129018313257 0.0725043768759201 no 3109 0.0514145519043997 4599 5560863 SGTC_320 4092-0846 5.34 µM -1.63242379251311 0.0723622774034768 no 3110 0.0512951201751425 4535 1359356 SGTC_3160 9100216 49.47 µM -1.63311158939502 0.0722761652032654 no 3111 0.0512227647888599 4547 17191039 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.63527795887171 0.0720054488280426 no 3112 0.0509953959574737 4566 75037 A free radical scavenger. SGTC_81 0411-0046 9.971 µM -1.63727899013208 0.0717560849618354 no 3113 0.0507860943979787 4566 12925265 SGTC_1450 4112-4260 37.6 µM -1.63802274120692 0.0716635694730606 no 3114 0.0507084749721535 4549 1633175 SGTC_799 1310-0557 151 µM -1.63862855973764 0.0715882791154463 no 3115 0.0506453203202124 4577 5354492 SGTC_2893 9048488 25.97 µM -1.63917653345178 0.0715202299268679 no 3116 0.0505882497812626 4592 6467338 SGTC_1331 1472-0049 76.2 µM -1.63999041127784 0.0714192515095549 no 3117 0.0505035803360003 4545 24051409 SGTC_2607 solasodine 47.35 µM -1.64211236887461 0.0711564932278897 no 3118 0.0502833594019104 4517 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3104 9120930 49.47 µM -1.65099425971329 0.0700647140910999 no 3119 0.0493698735129573 4593 17014836 SGTC_2821 7996764 71.43 µM -1.6516826875608 0.0699806323442729 no 3120 0.0492996268615926 4545 2987135 SGTC_2818 7996756 12.99 µM -1.65705586373411 0.0693270401337467 no 3121 0.0487540906502632 4589 2241621 SGTC_3239 9133757 49.47 µM -1.65779765743109 0.0692371790808957 no 3122 0.0486791571586522 4638 17036923 SGTC_360 0957-0399 1.01 µM -1.66076071899058 0.0688791280595765 no 3123 0.0483807566063019 4586 6752301 YPR165W RHO1 SGTC_726 3448-4391 34.2 µM -1.66630851297256 0.0682125830228071 no 3124 0.0478259910125212 4637 1356692 SGTC_2078 5212016 200 µM -1.67734921433681 0.0669009120111803 no 3125 0.04673710705755 4490 1899708 SGTC_2653 dihydrofissinolide 100 µM -1.67902911130402 0.0667030566484706 no 3126 0.0465731851749497 4653 6857746 SGTC_948 3448-0295 75.3 µM -1.68020229125339 0.0665651502967264 no 3127 0.0464589818552871 4550 678569 SGTC_12 0849-0099 9.267 µM -1.68031659577089 0.0665517257009162 no 3128 0.0464478668984701 4542 6071388 SGTC_1924 st058459 75.1 µM -1.68045547344043 0.0665354179094784 no 3129 0.0464343653237311 4547 688683 SGTC_359 0081-0058 15.9 µM -1.68808908331485 0.0656437859689992 no 3130 0.0456970648548701 4566 3494159 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.69198857952534 0.0651919004833716 no 3131 0.0453240755805709 4657 688801 SGTC_1529 apigenin 74 µM -1.69946756764936 0.0643319708386596 no 3132 0.0446155601965719 4580 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2427 5545055 42.75 µM -1.69968363053329 0.064307259697317 no 3133 0.0445952250172728 4525 5372858 SGTC_2355 9061122 103.12 µM -1.70351592970667 0.0638701838350806 no 3134 0.0442357797462256 4596 5302957 SGTC_714 4296-0578 26.1 µM -1.7041014477426 0.0638036091226521 no 3135 0.0441810681076968 4634 1589775 SGTC_1710 st031758 61.5 µM -1.70761999393877 0.0634046787002206 no 3136 0.0438534380092358 4628 5394341 SGTC_966 1300-0360 30.2 µM -1.71833817449701 0.0622014174606251 no 3137 0.0428674750864894 4586 70588 SGTC_602 3130-1533 38.1 µM -1.72083590463076 0.0619235888919429 no 3138 0.0426403025425733 4629 720941 SGTC_2314 7727897 200 µM -1.72187577846746 0.0618082071347841 no 3139 0.0425460117766465 4560 900724 SGTC_842 0271-0008 11.1 µM -1.72443201158029 0.0615252873273082 no 3140 0.0423149413957034 4614 1221709 SGTC_899 1083-0020 478 µM -1.72673482279002 0.0612712827491215 no 3141 0.0421076493268181 4627 767123 SGTC_1217 1183-1422 255 µM -1.73693842776853 0.0601556513078747 no 3142 0.0411990197931339 4623 2849664 SGTC_2824 7998404 51.95 µM -1.7384490647907 0.0599918429564781 no 3143 0.0410658588373044 4583 837851 SGTC_2163 5671233 125 µM -1.7402549527618 0.0597964772321503 no 3144 0.040907130092576 4553 701023 SGTC_2123 5259487 200 µM -1.74202512516112 0.0596054593789081 no 3145 0.0407520239557998 4608 2173474 SGTC_1815 st051655 58.2 µM -1.74385614020958 0.0594083795118307 no 3146 0.0405920891145205 4578 5984156 SGTC_392 N-ethylmaleimide 8.33 µM -1.75104555838403 0.0586394889690701 no 3147 0.0399690313838589 4583 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2785 7756463 72.73 µM -1.75358343986881 0.0583699420121258 no 3148 0.0397509553194063 4583 2201551 SGTC_193 1273-0060 1.558 µM -1.75408091752185 0.0583172194422929 no 3149 0.0397083214723452 4485 2847393 YHR072W ERG7 SGTC_2379 9035213 200 µM -1.75950316073009 0.0577449941172875 no 3150 0.0392460419323194 4614 646551 SGTC_1409 3909-8004 61.9 µM -1.7596431218034 0.0577302822725018 no 3151 0.0392341676253834 4644 2119279 SGTC_3114 9122766 49.47 µM -1.76053413982047 0.0576366930463823 no 3152 0.0391586421372486 4599 17176985 SGTC_2306 7482397 179.52 µM -1.77153638820451 0.0564908657670552 no 3153 0.0382357735890953 4590 891448 SGTC_1007 4101-0031 70 µM -1.786834172423 0.0549276020983333 no 3154 0.0369821472196923 4613 1146276 SGTC_2655 perillic acid 100 µM -1.78869196501028 0.0547401072388172 no 3155 0.0368322188464147 4663 5702197 An apoptosis inducer. SGTC_3015 9080845 49.47 µM -1.78899063517797 0.0547100116761929 no 3156 0.0368081618774856 4643 5296973 SGTC_2540 epiandrosterone 100 µM -1.7891999604787 0.0546889267659419 no 3157 0.0367913090240946 4640 441302 A steroid. SGTC_875 0709-0210 25.7 µM -1.79037397295778 0.0545707899229195 no 3158 0.0366969057713037 4610 6251364 SGTC_2164 5685496 200 µM -1.7912158973047 0.0544861942895041 no 3159 0.0366293280445355 4579 759046 SGTC_1622 st003707 19.4 µM -1.79792040151271 0.0538162294805717 no 3160 0.0360948113021096 4630 10140899 SGTC_1853 st056710 91.2 µM -1.80020862512152 0.0535890718112699 no 3161 0.0359138512189241 4641 269167 SGTC_407 eburnamonine 100 µM -1.80769678332346 0.0528510101244397 no 3162 0.0353268527571824 4507 3195 SGTC_737 1950-0117 57.9 µM -1.81075107767312 0.0525522921259997 no 3163 0.0350896961772302 4622 5393513 SGTC_570 0987-0065 62.6 µM -1.81251863886047 0.0523800331167242 no 3164 0.0349530483039194 4541 3104428 SGTC_2067 5224629 34.075 µM -1.82113311215587 0.0515469105261752 no 3165 0.0342933124990947 4608 2835000 SGTC_3178 9107506 49.47 µM -1.82179972832494 0.0514828825191463 no 3166 0.0342426895014831 4612 8897194 SGTC_3223 9129970 49.47 µM -1.82433640234315 0.0512398148624645 no 3167 0.0340506151461059 4632 17248386 SGTC_1821 st053465 65.6 µM -1.82468223118252 0.0512067478982797 no 3168 0.0340244980969956 4659 675086 SGTC_2850 9015429 58.44 µM -1.82796937930774 0.0508932891270325 no 3169 0.0337770736720989 4615 6457570 SGTC_2767 sibutramine 71.45 µM -1.83127253371757 0.0505798447020383 no 3170 0.0335299375505001 4618 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_416 estradiol valerate 100 µM -1.83158625172873 0.0505501553649638 no 3171 0.0335065433255488 4626 13791 A steroid. SGTC_1717 st033143 58.0435 µM -1.83613705746529 0.0501210401208867 no 3172 0.033168694409026 4631 674616 SGTC_3253 9135987 49.47 µM -1.8401141847523 0.0497484021075525 no 3173 0.0328757376009314 4650 4182430 SGTC_1034 k072-0165 12.7 µM -1.85058494068178 0.0487779056184165 no 3174 0.0321146439211596 4647 5835461 SGTC_1560 lithocholic acid 53.1 µM -1.85379568883026 0.0484833633072458 no 3175 0.031884197754051 4595 9903 A bile acid which acts as a detergent. SGTC_2497 7-hydroxyflavone 100 µM -1.86317943039389 0.0476306793824092 no 3176 0.0312185129339346 4638 5281894 SGTC_1029 k015-0030 64.7 µM -1.86335345432797 0.0476149803143833 no 3177 0.0312062770444498 4652 2208316 SGTC_2815 7968870 71.43 µM -1.8700918746106 0.047010273768236 no 3178 0.0307355303189702 4572 2977326 YHR190W ERG9 SGTC_3140 9094243 49.47 µM -1.87133288124064 0.0468995801021934 no 3179 0.0306494778379612 4618 19291112 SGTC_1057 3448-5381 134 µM -1.87390246350713 0.0466710464596145 no 3180 0.0304719349316435 4634 5497911 SGTC_743 1275-0778 158 µM -1.87557840639722 0.0465224734056489 no 3181 0.030356596912128 4634 2849257 YMR203W TOM40 SGTC_2413 inermin 26.06 µM -1.87656637286808 0.0464350677516259 no 3182 0.0302887749190178 4660 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1856 st057054 55.7 µM -1.87713689867186 0.0463846532547316 no 3183 0.0302496666523628 4625 1266018 SGTC_412 gemfibrozil 100 µM -1.88064466131836 0.0460756547797068 no 3184 0.0300101360528114 4616 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2065 5221596 34.26 µM -1.88134814555651 0.0460138844205226 no 3185 0.0299622878644854 4620 788581 SGTC_396 dithiazanine 1.25 µM -1.88297252713474 0.0458715076061437 no 3186 0.0298520455903993 4626 10578 An antihelmenthic. SGTC_1046 2001-0062 216 µM -1.88322792413901 0.0458491543347221 no 3187 0.0298347431516832 4613 739778 SGTC_1916 st067606 49.2 µM -1.89110150152738 0.0451643145140474 no 3188 0.0293053980662664 4553 19590279 SGTC_1130 3454-2858 15.9 µM -1.89285560339767 0.0450128703144376 no 3189 0.0291885373663926 4611 715628 YIL048W NEO1 SGTC_2844 9010103 25.97 µM -1.89382994392681 0.0449289252396556 no 3190 0.0291237928504239 4597 2480525 SGTC_877 0771-0151 33.1 µM -1.89482519335917 0.044843308896449 no 3191 0.0290577821737652 4662 6166523 SGTC_715 0868-0130 184 µM -1.89563476339982 0.0447737625497032 no 3192 0.0290041785595695 4696 2876258 SGTC_1175 0741-0056 27.6 µM -1.89759955491432 0.0446053377109751 no 3193 0.0288744265539462 4688 765927 SGTC_950 1165-0508 94.1 µM -1.90157862494722 0.0442658092952295 no 3194 0.0286131322840133 4642 6148369 SGTC_2666 tannic acid 100 µM -1.9025679281703 0.0441817175937938 no 3195 0.0285484736866795 4637 16134267 A thiamine antagonist. SGTC_627 1391-0720 175 µM -1.90997745829448 0.0435559873688963 no 3196 0.0280680578733642 4659 997839 SGTC_531 3788-1495 174 µM -1.90998299772001 0.0435555222575885 no 3197 0.0280677012446195 4647 2896655 SGTC_1404 3909-7820 48.3 µM -1.91231132032174 0.0433603820608953 no 3198 0.0279181373473361 4643 23741373 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.91616554457418 0.0430389056977454 no 3199 0.0276720137686993 4735 4620898 SGTC_1623 st003709 20.3 µM -1.91695726515734 0.0429731081921544 no 3200 0.0276216805003119 4653 16192618 SGTC_170 4197-0004 226 µM -1.9198451994962 0.0427337893453643 no 3201 0.0274387278243659 4658 218692 SGTC_1153 4055-0057 267 µM -1.9237273559213 0.0424137795758287 no 3202 0.0271943836047272 4698 882706 SGTC_3221 9128209 49.47 µM -1.92916558930774 0.0419687632797004 no 3203 0.0268551542830702 4684 16460723 SGTC_2675 theaflavin digallate 100 µM -1.92949850037533 0.0419416440665389 no 3204 0.0268345030341129 4622 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3255 9139072 49.47 µM -1.93939342241079 0.0411420520801061 no 3205 0.0262267254233762 4679 17646060 SGTC_2942 9052777 62.25 µM -1.94245301514781 0.0408973284683368 no 3206 0.0260411413195614 4673 6469503 SGTC_1605 st000082 49.1 µM -1.94253448814405 0.0408908279715726 no 3207 0.0260362145076347 4652 1114022 SGTC_1159 4092-0538 61.2 µM -1.94306672323754 0.0408483830797431 no 3208 0.0260040485171067 4692 717301 SGTC_2952 9073731 13.78 µM -1.94308027836945 0.0408473025467369 no 3209 0.0260032297377475 4643 16457353 SGTC_1009 4106-0057 9.87 µM -1.94612901415554 0.0406048642959769 no 3210 0.0258196220744889 4663 2928005 SGTC_1005 4092-0690 4.4 µM -1.95168148903049 0.0401663276573985 no 3211 0.0254880158307336 4672 1529343 SGTC_1868 st057644 42.7 µM -1.95284199003622 0.0400751587056391 no 3212 0.0254191606294771 4685 688665 SGTC_2030 5175110 200 µM -1.95397987125654 0.0399859300873456 no 3213 0.0253517988545034 4667 2831986 SGTC_2125 5246583 200 µM -1.95511562354469 0.0398970294769099 no 3214 0.0252847122969596 4662 835267 SGTC_703 3875-0075 71.8 µM -1.95712742335704 0.0397399509101002 no 3215 0.0251662444884396 4701 2850814 SGTC_1619 st003326 88.7 µM -1.97080388342503 0.0386853934053115 no 3216 0.0243731561757023 4654 2849032 SGTC_587 k089-0003 57 µM -1.97150431156465 0.0386320048240882 no 3217 0.0243331101648704 4628 9659696 SGTC_1472 k841-0093 193 µM -1.97572730495454 0.0383113873509975 no 3218 0.0240928353263951 4709 X1472 SGTC_2795 7780010 54.55 µM -1.97897713617605 0.0380661341122757 no 3219 0.0239092902679662 4640 953673 SGTC_1968 st069590 43.6 µM -1.97977843794137 0.0380058599346273 no 3220 0.0238642151248224 4645 6384066 SGTC_311 1315-0136 58 µM -1.9814796882414 0.0378781494594257 no 3221 0.0237687525000906 4699 6759207 SGTC_3061 glucosamine 200 µM -1.98386296845449 0.0376998290848791 no 3222 0.023635559071645 4624 91431 and experimental redox chemotherapeutic SGTC_1971 st069429 63.5 µM -1.98433446396447 0.0376646324516534 no 3223 0.023609283301813 4680 1246522 YGL099W LSG1 SGTC_1310 1188-0297 994 nM -1.99716686354104 0.0367169626529545 no 3224 0.0229035297052959 4591 1588352 SGTC_2905 7799065 20.05 µM -1.9977265359748 0.0366760788888645 no 3225 0.0228731578453666 4602 1296806 SGTC_1434 4073-0095 163 µM -2.00097636550788 0.036439415902 no 3226 0.0226974684746435 4700 24133745 SGTC_985 1493-0307 8.71 µM -2.00489492191597 0.0361557175476346 no 3227 0.0224871408570168 4710 3278274 SGTC_1603 st002045 67.8 µM -2.0070999315587 0.0359968745422917 no 3228 0.0223695117630698 4686 5887985 SGTC_2178 5812956 200 µM -2.00959386992242 0.0358179071949379 no 3229 0.0222370952935139 4663 5403383 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.01625458365853 0.0353434994739674 no 3230 0.0218866806804082 4675 6312947 SGTC_162 k030-0015 37.8 µM -2.02503150167031 0.0347262475866983 no 3231 0.0214320648148817 4708 1809920 YMR134W ERG29 SGTC_2654 protoveratrine a 100 µM -2.03078267873864 0.0343266074527522 no 3232 0.0211385224439065 4720 5702278 A heart drug and vasodilator. SGTC_2261 9010538 184.68 µM -2.0372644320936 0.0338807392751548 no 3233 0.0208117750492699 4665 6457250 SGTC_104 0074-0074 590.992 µM -2.04096950506929 0.0336280210627877 no 3234 0.0206269291499312 4625 3943124 SGTC_244 nsc-207895 1.295 µM -2.04383004451851 0.0334339704042264 no 3235 0.0204851699798193 4588 42640 SGTC_2911 7942208 15.64 µM -2.04527245070458 0.0333364719734546 no 3236 0.0204140025831894 4666 1243384 SGTC_1919 st067113 52.3 µM -2.04851245569377 0.0331183196099668 no 3237 0.0202549064464349 4652 1268243 SGTC_3121 9125696 49.47 µM -2.05326573520223 0.0328004067600171 no 3238 0.0200234060639379 4755 1235365 SGTC_1696 st025591 34.7925 µM -2.06336696169266 0.0321331587527525 no 3239 0.0195388882190494 4678 2787147 SGTC_3045 9092950 49.47 µM -2.07578713400061 0.0313281304437392 no 3240 0.0189568214181144 4674 44120432 SGTC_2563 tomatine 8.54 µM -2.07595497322383 0.0313173670168415 no 3241 0.0189490578062561 4629 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_995 3931-2021 34.6 µM -2.08182047889913 0.0309431322905381 no 3242 0.0186794352297449 4683 730143 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.09471337361209 0.0301335301208748 no 3243 0.0180982398351711 4716 6708784 An antioxidant flavonoid SGTC_405 ebelactone b 50 µM -2.10860233684867 0.0292811090178287 no 3244 0.0174894605060963 4692 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1659 st012954 42.1 µM -2.1134792745132 0.0289865832872599 no 3245 0.0172798835456791 4719 24207262 SGTC_3184 9108758 49.47 µM -2.1141819317231 0.0289443523516785 no 3246 0.0172498657381065 4758 902885 SGTC_1139 k015-0024 46.9 µM -2.11884989909164 0.0286650957452482 no 3247 0.017051577083851 4725 2766652 SGTC_2227 7312221 64.1025 µM -2.12963413485342 0.0280284991112398 no 3248 0.0166009153109754 4768 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_605 1315-0399 119 µM -2.14076115075949 0.0273840529852333 no 3249 0.0161466521700253 4745 24020461 SGTC_2395 5646831 180.19 µM -2.14243179897567 0.027288368967138 no 3250 0.0160793756603448 4662 6808628 SGTC_103 0844-0104 51.839 µM -2.14276382513637 0.0272693858949137 no 3251 0.0160660337190495 4541 5375804 SGTC_1144 3486-0183 12.5 µM -2.14415575322414 0.0271899244466422 no 3252 0.0160102045206398 4724 6744069 SGTC_2481 5478948 45.16 µM -2.14532280899005 0.0271234493290417 no 3253 0.0159635230273901 4692 77792 SGTC_1259 0671-0132 43 µM -2.15302621016055 0.0266880598069597 no 3254 0.015658309354117 4670 X1259 SGTC_1587 estradiol valerate 56.1 µM -2.15355747532342 0.0266582495634556 no 3255 0.0156374460904881 4750 13791 A steroid. SGTC_1755 st041960 45.185 µM -2.16014870808187 0.0262907111302812 no 3256 0.0153805796859593 4729 2257073 SGTC_1160 4092-0570 10.5 µM -2.16943647795805 0.0257800070982129 no 3257 0.0150247810371588 4726 4994975 SGTC_2124 5246320 200 µM -2.17513231088711 0.0254709385008187 no 3258 0.0148101013972356 4702 579342 SGTC_776 4476-4378 112 µM -2.19471424222799 0.0244319552165306 no 3259 0.0140920512221942 4743 2892008 SGTC_2224 6650123 117.647 µM -2.1980207094282 0.0242600793686445 no 3260 0.0139738150892422 4775 2908370 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.2082255378456 0.0237360055205832 no 3261 0.0136142775109426 4704 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1134 3477-0009 42.5 µM -2.21197668705744 0.0235457712753989 no 3262 0.0134841378993971 4704 3973534 SGTC_1241 0364-0022 50.8 µM -2.23089470427625 0.0226058064762992 no 3263 0.0128440523074511 4721 4563895 SGTC_1418 3966-3099 2.4 µM -2.23190518416534 0.022556502451269 no 3264 0.0128106150953265 4745 740335 SGTC_2179 6298986 200 µM -2.23390867828391 0.0224590146560964 no 3265 0.0127445412195381 4709 738374 SGTC_2571 chrysanthemic acid 100 µM -2.2346495693098 0.022423053829633 no 3266 0.0127201819243934 4703 2743 An insecticide. SGTC_1857 st056007 79.3 µM -2.24455685993053 0.0219468291153375 no 3267 0.0123982974189709 4734 619834 SGTC_1312 1218-2183 165 µM -2.24856458884825 0.0217566258312187 no 3268 0.0122701057399375 4760 6744073 SGTC_1391 3442-0225 151 µM -2.25009628565652 0.0216843015485711 no 3269 0.0122214169128487 4734 5227075 SGTC_1548 st061468 90.8 µM -2.254837022765 0.0214617375316697 no 3270 0.0120717802395258 4760 390799 SGTC_2375 9072683 200 µM -2.26026609705522 0.0212092330122941 no 3271 0.0119023703953132 4746 16798029 SGTC_1499 4480-0877 67.3 µM -2.26253998507118 0.0211042242894465 no 3272 0.0118320306558036 4750 2861909 SGTC_850 0388-0143 75.9 µM -2.26506722827409 0.0209880320055953 no 3273 0.0117542771590618 4753 67273 SGTC_2598 perillyl alcohol 100 µM -2.27669493153678 0.0204603897419432 no 3274 0.0114022247031638 4714 10819 An apoptosis inducer. SGTC_1422 4031-0024 15.5 µM -2.27951539534707 0.0203341101958393 no 3275 0.0113182229298232 4717 782427 SGTC_811 0416-0114 265 µM -2.28404178036505 0.0201328331263505 no 3276 0.0111845378094986 4734 6612453 SGTC_2643 anethole 100 µM -2.28813257597821 0.0199523816754625 no 3277 0.0110649008431341 4742 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_315 k915-0449 187 µM -2.30652568464622 0.0191578964303122 no 3278 0.0105406383278889 4747 20970215 YNL149C PGA2 SGTC_809 3998-0021 90 µM -2.33344085221041 0.0180438684489696 no 3279 0.00981250963420629 4727 715485 SGTC_110 0850-0284 111.64 µM -2.34731734592721 0.0174914189459214 no 3280 0.00945457090886745 4733 3906265 SGTC_1207 2099-0101 141 µM -2.35862026163464 0.017052162129449 no 3281 0.00917150761732235 4755 5837381 SGTC_942 3253-1115 227 µM -2.36946396468813 0.0166396478299177 no 3282 0.00890694546111205 4753 46497897 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.37376012290905 0.016478591953813 no 3283 0.00880399276255492 4728 5377381 SGTC_2966 9084041 48.03 µM -2.38501261608513 0.0160630663189542 no 3284 0.0085392678263112 4720 17741380 SGTC_903 1134-0042 114 µM -2.38502094758824 0.0160627620159827 no 3285 0.00853907443646002 4749 701009 SGTC_1905 st060207 84.5 µM -2.38548474157364 0.0160458300198479 no 3286 0.00852831496536071 4740 1948547 SGTC_354 2783-3500 4.88 µM -2.40226713627573 0.0154433533605654 no 3287 0.00814690239268218 4736 6740761 SGTC_2541 muurolladie-3-one 83.07 µM -2.40589775455811 0.0153156027115008 no 3288 0.00806638959669348 4727 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1747 st037496 66.6 µM -2.41152809899415 0.0151192829306033 no 3289 0.00794291385347585 4706 723305 SGTC_2233 sulbentine 40.3845 µM -2.41367508536446 0.0150449929912621 no 3290 0.00789626913891547 4755 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1569 carminic acid 40.6 µM -2.44624593623964 0.0139558823576751 no 3291 0.00721762477520629 4768 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2171 5739187 198.077 µM -2.45101319601138 0.0138023184565736 no 3292 0.00712273653606581 4737 2262761 SGTC_2606 farnesol 9.78 µM -2.49325124828317 0.012504240043333 no 3293 0.00632896212274842 4741 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_963 1269-2853 151 µM -2.49382650165391 0.0124873168615121 no 3294 0.0063187149271627 4749 3668223 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.51054909662025 0.0120039541665483 no 3295 0.00602717792061715 4750 442882 SGTC_1317 1273-0028 910 nM -2.55509923862405 0.0107946385909677 no 3296 0.0053078763615977 4763 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1368 1852-0141 284 µM -2.56399581301737 0.0105662730768163 no 3297 0.00517373964034734 4728 2838987 SGTC_2593 nobiletin 86.24 µM -2.57917879169137 0.0101862550015449 no 3298 0.00495177568439305 4744 72344 An anti-infammatory. SGTC_2976 9009005 19.48 µM -2.58146401783652 0.010130102265897 no 3299 0.00491911233322891 4744 2993148 SGTC_1586 deoxycorticosterone acetate 53.7 µM -2.59016459868697 0.00991877520678767 no 3300 0.00479650257049967 4778 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2974 9094440 9.66 µM -2.60325323662721 0.00960811880901295 no 3301 0.00461718584517412 4740 25236134 SGTC_105 0111-0055 734.78 µM -2.61769196186621 0.00927531501820283 no 3302 0.00442633398858703 4775 5179370 SGTC_3260 9137109 49.47 µM -2.62266775580485 0.00916298627378388 no 3303 0.00436221526033375 4774 17478346 SGTC_3141 9094609 49.47 µM -2.63002396298889 0.00899910157432301 no 3304 0.00426894248869932 4760 25236309 YDL196W YDL196W SGTC_213 1246-0773 967 nM -2.63067053149978 0.0089848205573869 no 3305 0.00426083022126583 4778 6251622 SGTC_1382 3002-2117 298 µM -2.6559468399007 0.00844186934793884 no 3306 0.00395430401897707 4781 1497314 SGTC_1962 st076595 64.5 µM -2.68412124529444 0.00787080100406987 no 3307 0.0036360364283629 4758 279619 SGTC_2081 5214970 32.255 µM -2.70254162996111 0.00751606893335618 no 3308 0.00344057834306071 4764 2063512 SGTC_1976 st070609 63.5 µM -2.71818869248438 0.00722588492518851 no 3309 0.00328201961800739 4773 682556 SGTC_1903 st060211 78.3 µM -2.72462145682515 0.00710948092138384 no 3310 0.00321876239241775 4777 688960 SGTC_2596 sinensetin 100 µM -2.72928874772418 0.00702606279006107 no 3311 0.00317355505893706 4747 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3217 9129673 49.47 µM -2.73382593826192 0.00694579921638815 no 3312 0.00313015644406313 4753 17248312 SGTC_1035 k081-0041 55.2 µM -2.73389602612624 0.00694456572695316 no 3313 0.0031294902583557 4778 731709 SGTC_329 k048-0121 21.3 µM -2.76508544263643 0.00641448216992505 no 3314 0.00284539438248524 4787 6832902 SGTC_1568 digitonin 820 nM -2.77126923780026 0.00631374339767142 no 3315 0.00279191176708371 4758 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_226 1,3-diallylurea 8.28947 mM -2.79724455620673 0.00590572017170502 no 3316 0.00257702523836632 4786 74537 YKL182W FAS1 SGTC_3266 9136860 49.47 µM -2.82369766565355 0.00551439684628378 no 3317 0.00237365713485054 4618 4871271 YPR165W RHO1 SGTC_2770 toltrazuril 17.5 µM -2.82377219932119 0.00551332761672316 no 3318 0.00237310525619187 4759 68591 Kills coccidiodes. SGTC_1578 josamycin 24.2 µM -2.83851702462723 0.00530539265626374 no 3319 0.00226618507538347 4781 5282165 A P450 substrate. SGTC_688 0527-0193 473 µM -2.86968388938369 0.00488867358838522 no 3320 0.00205441169762343 4787 4007154 SGTC_2279 7948423 32.93 µM -2.89214541300492 0.00460669842807198 no 3321 0.00191310405748929 4766 1247112 SGTC_2718 lomofungin 53.02 µM -2.90349752082276 0.00446978541293613 no 3322 0.00184509946248113 4780 5351222 A RNA synthesis inhibitor. SGTC_1723 st034307 2.5525 µM -2.90916075524179 0.0044028518252672 no 3323 0.00181200230675436 4773 867466 SGTC_2763 lisinopril 49.32 µM -2.92821731737372 0.00418415062228652 no 3324 0.00170455837186562 4764 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_101 0490-5701 117.494 µM -2.97819293309887 0.00365604879535235 no 3325 0.00144976701921296 4761 4661669 SGTC_1814 st052110 31.539 µM -2.99445678573595 0.00349756148116759 no 3326 0.00137466999419626 4776 674163 SGTC_1906 st060206 94.7 µM -3.11079872365405 0.00253242834566298 no 3327 0.000932910346650002 4792 5133468 SGTC_1378 2093-0007 380 nM -3.12564604439683 0.0024283937149639 no 3328 0.000887074756002052 4791 3618014 SGTC_2964 9083345 53.42 µM -3.12595612744424 0.00242626280595468 no 3329 0.000886139948411114 4778 17741579 SGTC_376 3970-0862 59.1 µM -3.1601549828036 0.00220137080368543 no 3330 0.00078842618492862 4796 3135186 SGTC_1728 st035614 33.7865 µM -3.18678278203273 0.00203953870949493 no 3331 0.000719323880039147 4779 15945546 SGTC_1266 0828-0227 32.9 µM -3.20202822312 0.00195182014822528 no 3332 0.000682318136347334 4787 3913820 SGTC_245 methotrexate 289.6 µM -3.25995473701114 0.00164889244710454 no 3333 0.000557149975075197 4775 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1975 st070967 30.8 µM -3.26826525854991 0.00160913367362512 no 3334 0.000541044490730841 4789 261391 SGTC_1887 st057648 70.8 µM -3.28903991314407 0.00151353695668419 no 3335 0.00050264883255192 4801 688672 SGTC_1744 st037937 38.9 µM -3.29692295107022 0.0014786392283554 no 3336 0.000488751565155171 4797 1016152 SGTC_1743 st037606 46.3785 µM -3.45721209200322 0.000910680603275381 yes 3337 0.000272897551821493 4788 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2271 7849410 118.62 µM -3.46727091026785 0.000882815343364351 yes 3338 0.00026288584943119 4783 972430 SGTC_3143 9086658 49.47 µM -3.50173796172474 0.000793171545405655 yes 3339 0.00023111699424309 4777 25236626 SGTC_1374 2889-5571 141 µM -3.5227342676792 0.000742751745701894 yes 3340 0.000213559687410135 4800 2853281 SGTC_1718 roemerine 11.9335 µM -3.67571193182004 0.000455565466426509 yes 3341 0.00011859352189997 4648 235224 An aporphine alkaloid with mutagenic activity. SGTC_1261 0712-0010 12.7 µM -3.71799188386032 0.000396722823097396 yes 3342 0.000100406360115221 4803 2840123 SGTC_1600 coumarin 106 71.1 µM -3.71899835029798 0.000395412172211774 yes 3343 0.000100007179007392 4807 100336 A hepatotoxic, DNA x-linker. SGTC_2111 5486399 200 µM -3.85181967195167 0.000253740428143409 yes 3344 5.86216747601405e-05 4799 689674 SGTC_2110 5483698 200 µM -3.85519987732588 0.000250846908765958 yes 3345 5.78175565420545e-05 4801 2848765 YHR062C RPP1 SGTC_1874 staurosporine 7.6 µM -3.94739315301943 0.000182837146309045 yes 3346 3.95033792597811e-05 4809 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -3.97340054060769 0.000167031700403489 yes 3347 3.54268759217999e-05 4807 688803 SGTC_1594 piperine 70.1 µM -4.01632732233491 0.000143709820943221 yes 3348 2.95560700479706e-05 4806 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1632 st005650 90 µM -4.05550246255085 0.000125122577802616 yes 3349 2.50133226956812e-05 4803 2759605 SGTC_2121 5257820 149.641 µM -4.09866659339712 0.000107264451592481 yes 3350 2.07768548987953e-05 4809 791256 SGTC_352 k048-0007 5.11 µM -4.13305526503734 9.4780528091093e-05 yes 3351 1.78986303624083e-05 4790 6811911 SGTC_923 1900-2434 73.3 µM -4.14594444317548 9.04637079398345e-05 yes 3352 1.69207940883211e-05 4800 5910570 SGTC_2079 5212404 121 µM -4.23594296609611 6.5093521530332e-05 yes 3353 1.1379727290808e-05 4805 758462 SGTC_1749 st037932 54.2 µM -4.67279983589104 1.20327752334573e-05 yes 3354 1.4856065069725e-06 4803 594497 SGTC_1882 5615643 20 µM -5.0886079406377 2.09697167942249e-06 yes 3355 1.80350726803423e-07 4810 2253075 SGTC_58 0957-0393 9 µM -5.22142943169303 1.1658342117446e-06 yes 3356 8.87736433936235e-08 4704 6997992