SGTCid condition conc unit NEW1|YPL226W.score NEW1|YPL226W.strain.pval NEW1|YPL226W.strain.significant NEW1|YPL226W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_770 0389-1121 67.2 µM 6.50671379174917 1.22556018626092e-10 yes 1 3.84062787640213e-11 3 6753108 SGTC_383 2324-0395 7.37 µM 6.50025598714091 1.27562239469129e-10 yes 2 4.00917254449935e-11 14 3146421 SGTC_2688 kanamycin b 96.69 µM 6.16662195399399 9.59323857238055e-10 yes 3 3.48821397527492e-10 149 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2985 9022375 71.43 µM 5.84210890225728 6.20572352481118e-09 yes 4 2.57720455475702e-09 6 4939335 SGTC_2917 7979103 53.79 µM 5.83585995245373 6.42695723971391e-09 yes 5 2.67569159764211e-09 4 2980565 SGTC_3031 9088762 49.47 µM 5.77410455525032 9.06848927267383e-09 yes 6 3.86816946595057e-09 2 205253 SGTC_932 2857-0803 154 µM 5.68229389535137 1.50351932870966e-08 yes 7 6.64500126189918e-09 8 674898 SGTC_2211 7117706 200 µM 5.58028829466733 2.61361381653437e-08 yes 8 1.20060126833464e-08 2 822771 SGTC_167 3672-0051 66.205 µM 5.40336046135133 6.67135342788074e-08 yes 9 3.27019194246682e-08 17 3237971 SGTC_1246 0422-0085 105 µM 5.26523929432239 1.35995915993218e-07 yes 10 7.00034359548671e-08 8 264295 SGTC_602 3130-1533 38.1 µM 4.87498403569848 9.28488359671951e-07 yes 11 5.44086273985603e-07 3 720941 SGTC_2466 5983409 37.09 µM 4.64786081602316 2.66919152998842e-06 yes 12 1.67697543711211e-06 14 2879657 SGTC_929 2805-0021 398 µM 4.64689349808865 2.6809621235107e-06 yes 13 1.68485511916711e-06 6 3098024 SGTC_2071 5230951 39.92 µM 4.61715595893748 3.06805148196537e-06 yes 14 1.94517449613563e-06 11 1799272 SGTC_2630 antimycin a 100 µM 4.58314688303152 3.5762953924005e-06 yes 15 2.29015030091675e-06 23 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_998 3996-0085 177 µM 4.5636691489545 3.90266022631595e-06 yes 16 2.51336372095222e-06 10 715391 SGTC_1319 1306-0155 43.7 µM 4.55396704264015 4.07566743796373e-06 yes 17 2.63218035403409e-06 13 3122360 SGTC_3021 9087658 49.47 µM 4.55178429575312 4.11558799340607e-06 yes 18 2.65964285945688e-06 4 25237042 SGTC_576 1073-0113 22.7 µM 4.49867285466695 5.21043068725403e-06 yes 19 3.4189493350732e-06 49 5439563 SGTC_2183 6420625 130.508 µM 4.4396404309456 6.75261441273115e-06 yes 20 4.50546505560476e-06 37 2897619 SGTC_1728 st035614 33.7865 µM 4.35295640385235 9.82661225822578e-06 yes 21 6.71569337827728e-06 34 15945546 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 4.31019509085231 1.17956959774975e-05 yes 22 8.15552924159555e-06 9 390807 SGTC_436 n,n-dimethylsphingosine 3.3 µM 4.30994322127433 1.18083362386029e-05 yes 23 8.16482334478193e-06 19 5282309 SGTC_2453 5731132 22.18 µM 4.27774089728779 1.35350380590114e-05 yes 24 9.43997972236624e-06 13 1362040 SGTC_2094 5332512 191.667 µM 4.25061037720825 1.51736102198101e-05 yes 25 1.06594371543414e-05 19 755774 SGTC_1416 3966-0321 25.3 µM 4.17406386788805 2.08739829181103e-05 yes 26 1.49606907574018e-05 11 582530 YLR208W SEC13 SGTC_581 0958-0271 211 µM 4.03244456067956 3.71543070943055e-05 yes 27 2.75998197840312e-05 50 4591145 SGTC_2195 6536160 144.242 µM 4.0286785688047 3.7719347407245e-05 yes 28 2.80456236278014e-05 9 3834386 SGTC_3072 9116419 49.47 µM 4.00996771510147 4.06492189255743e-05 yes 29 3.03635252661489e-05 14 17170162 SGTC_1032 k061-1018 98.7 µM 3.96021220801776 4.95220528837549e-05 yes 30 3.74415948017563e-05 21 4005393 SGTC_654 1124-0271 80.9 µM 3.92349065035749 5.72113270464486e-05 yes 31 4.36375769634979e-05 21 5403748 SGTC_822 1487-0950 154 µM 3.9174244769898 5.85851895311728e-05 yes 32 4.47500361115201e-05 12 1958375 SGTC_2704 st078022 71.1 µM 3.85060877764281 7.59242806355467e-05 yes 33 5.89122918481759e-05 15 54697681 SGTC_2932 9016711 44.54 µM 3.83562400251245 8.04267272225218e-05 yes 34 6.26229470638092e-05 49 7117328 SGTC_2447 5741742 33.78 µM 3.81340405112355 8.75678063214912e-05 yes 35 6.85328764340594e-05 25 1776504 SGTC_1559 coumarin 343 70.1 µM 3.79612251356972 9.35295567870328e-05 yes 36 7.34884422593714e-05 16 108770 A hepatotoxic, DNA x-linker. SGTC_625 k213-0058 121 µM 3.77891110084231 9.98447524853684e-05 yes 37 7.87578204809377e-05 119 3655420 SGTC_212 3807-4682 38.772 µM 3.75769847895238 0.000108179438305491 yes 38 8.57416687887808e-05 77 3125501 YBL034C STU1 SGTC_1967 st070177 51.4 µM 3.58545246160149 0.000204458609384651 yes 39 0.000168247148625031 24 5729214 SGTC_3301 9125354 19.7965 µM 3.54869202575567 0.000233433576147534 yes 40 0.000193574798896686 23 41905162 SGTC_1633 st005664 67.9 µM 3.5459791290094 0.00023571703530685 yes 41 0.00019557859297533 48 2063822 SGTC_708 3448-5400 146 µM 3.5451677732994 0.000236403994933749 yes 42 0.000196181629688466 58 3462195 SGTC_40 0327-0103 19.753 µM 3.5139548558351 0.00026429409249232 yes 43 0.000220743918363877 42 409036 SGTC_2204 7233102 200 µM 3.42757078232649 0.000358282418501393 yes 44 0.00030450375751646 9 2172480 SGTC_2089 5281248 129.67 µM 3.41592489332952 0.000373100724114555 yes 45 0.000317828882742927 41 2737878 SGTC_850 0388-0143 75.9 µM 3.40723817089157 0.000384522216200514 yes 46 0.000328119181917259 25 67273 SGTC_791 1348-1292 225 µM 3.38991525925152 0.000408274015660493 yes 47 0.0003495711589249 58 5437054 SGTC_2208 7283366 200 µM 3.37142211888321 0.000435127719150339 yes 48 0.000373905895760382 16 898663 SGTC_1921 5740136 50 µM 3.3638499900633 0.000446588461808002 yes 49 0.000384316546574381 85 1774243 SGTC_999 SEC7.066 22.7 µM 3.33165371469662 0.000498512611333516 yes 50 0.000431658037658123 65 740511 YDR170C SEC7 SGTC_1248 0469-0687 58.6 µM 3.31608095855433 0.000525584078897659 yes 51 0.00045644689434809 55 4017482 SGTC_387 norethindrone acetate 66.7 µM 3.29559818742192 0.00056326354606191 yes 52 0.000491061881964172 38 541197 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 3.2736033113759 0.000606494423348148 yes 53 0.00053092782981805 65 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1005 4092-0690 4.4 µM 3.25406577187829 0.000647444952803404 yes 54 0.000568829683504518 52 1529343 SGTC_1752 st044819 83.042 µM 3.23374815785406 0.000692725435596392 yes 55 0.000610885703158453 47 441209 YML126C ERG13 SGTC_177 1327-0068 8.361 µM 3.23369190225557 0.000692854765883653 yes 56 0.000611006034569566 76 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1763 st044482 94.5 µM 3.22059076885728 0.000723587723893424 yes 57 0.00063963337495374 40 88505 SGTC_272 doxorubicin 8.13 µM 3.1980084030892 0.000779527183748446 yes 58 0.000691901239870607 58 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3148 9097893 49.47 µM 3.15017800095284 0.000911387776610311 yes 59 0.000815855071586218 70 17174100 SGTC_3327 9140648 26.9345 µM 3.13218057050359 0.00096609951052906 yes 60 0.000867565618020327 30 8029710 SGTC_3194 9111903 49.47 µM 3.1295875796567 0.000974226099405727 yes 61 0.000875259409040828 54 17087251 SGTC_2019 4016004 108 µM 3.11550718157958 0.0010194610911372 no 62 0.00091814438606302 67 45595336 SGTC_3142 9086498 49.47 µM 3.08891635507055 0.00111018209965086 no 63 0.00100443994621329 77 25236367 SGTC_2018 5133068 143 µM 3.08817283112939 0.00111282198221173 no 64 0.00100695654619701 67 785362 SGTC_2857 9024691 58.44 µM 3.07658315136651 0.0011547217524779 no 65 0.00104693946403417 67 16478292 SGTC_1382 3002-2117 298 µM 3.04761672967848 0.00126583831036231 no 66 0.00115331959545349 41 1497314 SGTC_2710 st078562 53.7235 µM 3.02754664704692 0.00134847363209901 no 67 0.00123273829410433 43 17250908 SGTC_1672 st016598 6.51 µM 2.99100221639038 0.00151170847545657 no 68 0.00139031737545982 121 4665860 YNL267W PIK1 SGTC_620 0109-0052 432 µM 2.98146265445333 0.00155718826328046 no 69 0.00143437516866697 57 493037 SGTC_2400 5203494 178.7 µM 2.95848958881952 0.00167187601719697 no 70 0.00154575342276267 61 6777674 SGTC_1144 3486-0183 12.5 µM 2.91311206027848 0.00192129553208464 no 71 0.0017892308027613 71 6744069 SGTC_2711 st079103 59.1 µM 2.91087984586812 0.00193439564802053 no 72 0.0018020629328027 37 54693780 SGTC_1617 st002906 78 µM 2.9052593038637 0.00196774086155942 no 73 0.00183474479777929 82 5150859 SGTC_286 k060-0067 22.9 µM 2.89290326273956 0.00204288841003562 no 74 0.00190849419398839 59 5985051 SGTC_912 3474-0017 2.18 µM 2.89234122735441 0.00204636775201491 no 75 0.00191191198571414 76 3360550 SGTC_2665 lovastatin 100 µM 2.89197471789637 0.00204863956528357 no 76 0.00191414376011844 61 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1480 1070-0044 41.2 µM 2.88692000010646 0.00208020561423601 no 77 0.00194516566525056 69 3124987 SGTC_2561 acetosyringone 100 µM 2.87634840915683 0.0021476546803111 no 78 0.00201152690954473 90 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_869 0564-0080 44.1 µM 2.86297681652351 0.00223580670872532 no 79 0.00209840634804045 87 6843321 SGTC_2486 5283202 22.39 µM 2.83829362582934 0.00240718715946466 no 80 0.00226777192010385 90 1377751 SGTC_251 melphalan 456.522 µM 2.8291454439671 0.00247366561315431 no 81 0.00233362414494577 92 460612 A DNA alkylator. SGTC_2190 6049624 200 µM 2.81556575144412 0.00257541151913976 no 82 0.00243457160527783 31 2265554 SGTC_1966 st070145 16.1 µM 2.81336453491179 0.00259225580907988 no 83 0.00245130190280333 75 3748532 SGTC_421 streptovitacin 30 mM 2.81257840056696 0.00259829559953686 no 84 0.0024573020566238 91 91467 include heat shock SGTC_1302 1159-0335 255 µM 2.80566779695604 0.0026519387245 no 85 0.00251062150519216 54 649284 SGTC_2716 st080858 38.6235 µM 2.78730949390566 0.00279933587149929 no 86 0.00265738466085987 66 5296050 SGTC_118 0083-0097 135.343 µM 2.78391661732754 0.00282737261634071 no 87 0.00268534195257738 308 5207356 SGTC_2521 angolensin 13.4 µM 2.76829301114676 0.00295977338618469 no 88 0.00281753838936361 59 821428 A flavenoid. SGTC_2849 9019321 12.99 µM 2.75425116294477 0.00308350990824656 no 89 0.00294133022728451 97 16489627 SGTC_1935 st074532 41.6 µM 2.73473180853813 0.00326325260737449 no 90 0.00312155597002658 110 2829742 SGTC_1364 1653-0028 37.6 µM 2.72692664208935 0.00333772507834639 no 91 0.00319636247811206 88 5718652 SGTC_2334 9017922 200 µM 2.71998963045065 0.00340519278155058 no 92 0.00326419817675129 86 3163164 SGTC_2944 9067346 25.62 µM 2.71688094985813 0.00343582276069637 no 93 0.00329501536193102 103 6473075 SGTC_653 0203-0016 55.2 µM 2.6980099997566 0.00362712928961429 no 94 0.00348776726376718 85 295302 SGTC_2754 granisetron 64.02 µM 2.66098917392023 0.00403042186175761 no 95 0.00389557310829785 123 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1243 0416-0003 5.65 µM 2.65539370592761 0.00409475084797371 no 96 0.00396079471313389 121 2141977 SGTC_1923 st058458 19.1 µM 2.65084403996877 0.00414773232682001 no 97 0.00401454537022767 131 3534982 SGTC_2210 7115885 190.385 µM 2.64834123459048 0.00417713859559734 no 98 0.00404439164397255 101 2927039 SGTC_3211 9128781 49.47 µM 2.64206827074027 0.00425166278568334 no 99 0.00412007221220643 160 17194361 SGTC_2943 9068529 45.32 µM 2.61389535978457 0.00460122842471483 no 100 0.0044758223982685 113 3270634 SGTC_1557 sumaresinolic acid 42.3 µM 2.61267801185166 0.00461689527938314 no 101 0.00449179473260515 99 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_950 1165-0508 94.1 µM 2.59925423950428 0.00479283779212083 no 102 0.00467132749157065 110 6148369 SGTC_1486 3970-0793 4.53 µM 2.58678848427041 0.0049615517010869 no 103 0.00484375194980046 61 2844330 SGTC_1854 st056233 32.9 µM 2.5809731259723 0.00504205236826557 no 104 0.00492611254732274 94 5393174 SGTC_1166 k206-0078 225 µM 2.55202578672116 0.005460319109613 no 105 0.00535492959064773 106 5404595 SGTC_1876 myriocin 605 nM 2.54085236621326 0.0056298396209275 no 106 0.00552913011566046 108 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2420 aureobasidin a 50 nM 2.53493962724156 0.00572142388111923 no 107 0.00562333535481669 152 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1758 st042942 75.2445 µM 2.53283460194855 0.00575434707483656 no 108 0.00565721631718437 94 669317 SGTC_3341 9147222 25.867 µM 2.53003483082182 0.00579839677515179 no 109 0.00570256020202766 89 1939759 SGTC_1331 1472-0049 76.2 µM 2.51438722850042 0.00605013802511798 no 110 0.00596197152011392 127 24051409 SGTC_876 0720-0963 56.8 µM 2.51042077414166 0.00611547035327041 no 111 0.00602936888241524 93 765861 SGTC_1583 clindamycin 39.6 µM 2.50049528849336 0.00628170198433738 no 112 0.00620098913321986 110 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.48614514099893 0.00652911001855327 no 113 0.00645676431923726 133 688667 SGTC_2124 5246320 200 µM 2.48168590760722 0.00660772649144617 no 114 0.00653812399196381 123 579342 SGTC_1278 0874-0585 172 µM 2.48083677424097 0.0066227912492954 no 115 0.00655371897030127 102 766306 SGTC_1693 xanthone 101.9 µM 2.47487970208541 0.00672933404399479 no 116 0.00666405303689911 100 7020 An insecticide. SGTC_914 3820-6779 408 µM 2.47487823970594 0.00672936038366791 no 117 0.00666408032276055 124 2893481 SGTC_39 0986-0283 58.349 µM 2.47177259339288 0.00678550374989935 no 118 0.00672225041480854 149 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_800 3448-7362 155 µM 2.46956462651953 0.00682567031046484 no 119 0.00676387904755872 384 15991913 SGTC_2846 9008642 19.48 µM 2.46491428711824 0.00691095528301766 no 120 0.00685230153035386 98 2992898 SGTC_3192 9110362 49.47 µM 2.45950298909219 0.0070113792364344 no 121 0.00695647695239849 92 16649480 SGTC_3047 9092122 49.47 µM 2.44004701137093 0.00738316800787238 no 122 0.00734267534628556 121 17173831 SGTC_1358 1509-0022 2.48 µM 2.43205823691142 0.00754079061288607 no 123 0.00750664658471247 105 3258434 SGTC_3330 9141424 71.43 µM 2.42941781113924 0.00759353535222103 no 124 0.00756154665794464 118 27261020 SGTC_2947 9072639 7.68 µM 2.42414185736992 0.00769990093288841 no 125 0.00767230510825903 187 16488146 SGTC_1682 st012968 530 nM 2.41951715607321 0.00779421331389994 no 126 0.00777056380723912 115 24207270 SGTC_1191 1487-1166 10.6 µM 2.41910472780647 0.0078026731979746 no 127 0.00777938000845529 146 3955771 SGTC_1001 4048-4355 44.4 µM 2.41546529557771 0.00787767749143646 no 128 0.00785755999538973 142 21824233 SGTC_605 1315-0399 119 µM 2.4142661276863 0.00790252941800226 no 129 0.00788347071389762 134 24020461 SGTC_317 4495-0002 170 µM 2.41408985436095 0.00790618836799812 no 130 0.00788728582414316 100 15991618 SGTC_959 1222-0044 107 µM 2.39892979588136 0.00822649721118879 no 131 0.00822153344407484 128 6083612 SGTC_1705 st027868 56.3335 µM 2.39078951891241 0.00840314877356092 no 132 0.00840609400180708 106 292948 SGTC_596 1155-0152 116 µM 2.38937305929768 0.00843422506491607 no 133 0.00843857753807958 179 280313 SGTC_446 go6976 132 µM 2.38271844505746 0.00858157743573915 no 134 0.00859266628644335 105 3501 A protein kinase C inhibitor. SGTC_3281 9140613 49.47 µM 2.37737824007181 0.00870145348620346 no 135 0.00871809922618324 118 16013766 SGTC_1283 0922-0125 16.4 µM 2.37373599202231 0.00878405401318187 no 136 0.00880456810732027 121 3360884 SGTC_2690 usnic acid 100 µM 2.36680935899454 0.00894303749610913 no 137 0.00897108612874718 162 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1275 0867-0008 21.1 µM 2.36618177772729 0.00895756583679479 no 138 0.00898630877306367 128 3422836 SGTC_426 0988-0037 14.6 µM 2.36406323877779 0.00900676227400596 no 139 0.00903786340407021 165 5383008 SGTC_496 calpeptin 138 µM 2.36332001659936 0.00902407727381422 no 140 0.0090560109900106 125 73364 A calpain inhibitor. SGTC_1498 4478-3555 97.6 µM 2.35290297965909 0.0092698508321145 no 141 0.0093137468033047 63 3437919 SGTC_19 0279-0214 38.434 µM 2.31163258078651 0.0103020432207745 no 142 0.0103989697964512 235 3566274 YBR002C RER2 SGTC_443 clozapine 122 µM 2.30915717923408 0.0103670224324761 no 143 0.0104674303849153 88 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1348 1493-0373 93.8 µM 2.29587579357368 0.0107217943758534 no 144 0.0108414920846864 138 3010129 SGTC_253 dyclonine 31.25 µM 2.29349528464758 0.0107864875342405 no 145 0.0109097532619832 173 3180 An oral anasthetic. SGTC_129 0088-0017 176.636 µM 2.28907636338109 0.0109074782394116 no 146 0.0110374579468576 205 182446 SGTC_2587 piperic acid 92.2 µM 2.28094147810483 0.01113330316781 no 147 0.0112759550440976 159 5370536 SGTC_2432 5630864 12.22 µM 2.2801077418564 0.011156675828389 no 148 0.0113006495909376 176 5714970 SGTC_2433 5607874 27.82 µM 2.27776766256119 0.0112225048304832 no 149 0.0113702119771287 159 2252428 SGTC_840 0245-0196 390 µM 2.27538116092353 0.0112899872622476 no 150 0.0114415372523631 149 3827528 SGTC_673 1082-0474 110 µM 2.27384389598302 0.0113336425859304 no 151 0.0114876869728471 237 3098046 SGTC_3094 9117742 49.47 µM 2.27201812722135 0.0113856813624328 no 152 0.0115427077439466 179 17149698 SGTC_2224 6650123 117.647 µM 2.25602794206119 0.0118503796923627 no 153 0.0120344406303049 77 2908370 SGTC_2884 9058502 51.95 µM 2.24337465984941 0.0122296801920811 no 154 0.0124363322746121 171 6471554 SGTC_3246 9135460 32.98 µM 2.22148931626724 0.0129105868668938 no 155 0.0131589187669989 97 41446951 SGTC_928 2764-0428 58.7 µM 2.21570682688151 0.013095879198824 no 156 0.0133557935265284 214 662578 SGTC_3325 9138760 55.175 µM 2.20980431716028 0.0132873834609374 no 157 0.0135593729931443 176 43844959 SGTC_1436 4092-1007 8.32 µM 2.20473264679218 0.0134538589895066 no 158 0.0137364304056357 150 2881121 SGTC_2845 9003024 42.97 µM 2.19938224212774 0.0136314327859416 no 159 0.0139253771196303 226 2990173 SGTC_2155 5570423 76 µM 2.19208597609649 0.0138768447068354 no 160 0.0141866495866093 135 797402 SGTC_1916 st067606 49.2 µM 2.15879052832946 0.015045693254282 no 161 0.0154332108226701 224 19590279 SGTC_1640 st009078 66.4 µM 2.1537015916825 0.0152315968248367 no 162 0.0156317906250682 140 690618 SGTC_1769 st044406 64.4 µM 2.14996305700925 0.0153694230558764 no 163 0.015779068545938 175 670903 SGTC_1136 pergolide 1.05886 µM 2.1461799216928 0.0155099823029889 no 164 0.0159293134195847 282 47811 A dopamine receptor agonist. SGTC_1638 st008370 60.6 µM 2.14526812159022 0.015544024018292 no 165 0.0159657078802449 206 24207134 SGTC_1514 1189-1591 158 µM 2.14044400593086 0.0157251996159518 no 166 0.0161594507000788 234 767698 YMR146C TIF34 SGTC_314 1671-0008 2.74 µM 2.12760156380079 0.0162163669672379 no 167 0.0166850662348469 254 3913060 SGTC_1185 1319-0113 81.3 µM 2.127025314702 0.0162387106900406 no 168 0.0167089899518843 147 4672763 SGTC_1878 temozolomide 1 mM 2.12492557348867 0.0163203501916021 no 169 0.0167964118413899 138 5394 DNA alkylating agent. SGTC_2235 salicylic acid 500 µM 2.12234687335835 0.0164210926775316 no 170 0.0169043099949974 117 338 A COX inhibitor and kinase inhibitor. SGTC_1859 st055998 20 µM 2.11809701060473 0.0165882845682541 no 171 0.0170834263322889 184 676301 SGTC_2129 girgensonine 121.053 µM 2.11763516762419 0.0166065411761983 no 172 0.017102988707248 219 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2836 9010338 19.48 µM 2.11292224736456 0.0167938275228172 no 173 0.0173037116744312 205 2994051 SGTC_359 0081-0058 15.9 µM 2.10989949506901 0.0169148969931301 no 174 0.0174335068845065 221 3494159 SGTC_419 nsc-638432 893 µM 2.10626003344419 0.0170616568816015 no 175 0.0175908854685068 179 368090 SGTC_95 0471-0001 561.058 µM 2.09900254902429 0.0173575633359797 no 176 0.0179083380159884 204 4015405 SGTC_691 1548-0686 185 µM 2.09429988025649 0.0175516345459014 no 177 0.0181166375034285 238 46495133 SGTC_1864 st057645 30.4 µM 2.09050500725472 0.0177095901571531 no 178 0.018286229532722 135 688666 SGTC_2320 7373003 200 µM 2.08655834166138 0.0178751490039747 no 179 0.0184640381377138 185 5415828 SGTC_2706 st078239 82.5 µM 2.07968427560117 0.0181666619200282 no 180 0.0187772506508533 184 15434492 SGTC_1482 3346-2049 8.48 µM 2.06899035732406 0.0186282169037518 no 181 0.0192734957852117 186 3826804 SGTC_400 oxethazaine 37.5 µM 2.05363512251296 0.0193083902348447 no 182 0.0200055100523919 199 4621 A local anesthetic. SGTC_1564 D-Arginine 115 µM 2.05186988466873 0.0193879189414048 no 183 0.0200911546527594 220 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2856 9022925 19.48 µM 2.04925941669685 0.0195060375464564 no 184 0.0202183774002344 223 4944862 SGTC_173 1273-0061 2.693 µM 2.04193267564333 0.0198408283704715 no 185 0.0205791049954399 354 2847414 YPL266W DIM1 SGTC_1695 st026914 34.495 µM 2.03777597069282 0.0200329254878164 no 186 0.0207861712625074 216 3289191 SGTC_575 k072-0246 11.9 µM 2.03537967925584 0.0201443824463661 no 187 0.0209063421975565 209 6796779 SGTC_694 1315-0438 43.2 µM 2.03038585582303 0.0203783471755225 no 188 0.0211586666232187 162 6793154 SGTC_582 0987-0078 156 µM 2.02403338532494 0.0206792902209039 no 189 0.0214833583968275 346 1625765 SGTC_2024 5144227 134 µM 2.0152528157617 0.0211014528786742 no 190 0.0219390830452488 246 3475211 SGTC_1101 ebselen 5.29 µM 2.01375647299245 0.0211741181364671 no 191 0.0220175538410153 214 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1607 st000305 50.6 µM 1.9960731609175 0.022049004171048 no 192 0.0229629799655091 205 5457690 SGTC_982 1491-0518 27.5 µM 1.9913064132748 0.022289995873036 no 193 0.0232236054144209 189 3091256 SGTC_808 0711-0032 135 µM 1.98958503876147 0.0223775675332486 no 194 0.0233183327984698 194 4252555 SGTC_3258 9138477 49.47 µM 1.98615736600869 0.0225528083002315 no 195 0.0235079265750318 201 4970355 SGTC_1764 st044502 93.5 µM 1.98605983995064 0.0225578112293962 no 196 0.0235133399210046 243 8407 SGTC_5 0352-0601 109.883 µM 1.98564214666132 0.0225792488069599 no 197 0.023536536546376 163 762456 SGTC_78 0336-0123 156.75 µM 1.98230877385472 0.0227509461842116 no 198 0.0237223463218583 189 6765896 SGTC_828 2074-0507 139 µM 1.98025795943841 0.0228571264943981 no 199 0.0238372750705181 240 X828 SGTC_2477 5967686 25.23 µM 1.9772247678601 0.0230149343014074 no 200 0.0240081145779258 228 776118 SGTC_38 0929-0051 58.268 µM 1.97558173193678 0.0231007989858884 no 201 0.0241010846720468 249 1379719 SGTC_1145 3546-0597 10.2 µM 1.97090217599986 0.023346830977238 no 202 0.0243675330981334 246 875334 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.9474655595892 0.0246124510029526 no 203 0.0257394724362189 201 2724278 An inhibitor of dopamine biosynthesis. SGTC_3251 9135047 49.47 µM 1.94659434873857 0.0246605866963653 no 204 0.0257916933342507 163 17682963 SGTC_732 3970-1727 52.7 µM 1.94221355807999 0.0249038306321374 no 205 0.0260556262136373 191 1275699 SGTC_3140 9094243 49.47 µM 1.93490182184393 0.0253142959961855 no 206 0.0265011723005747 255 19291112 SGTC_3137 9097352 49.47 µM 1.93177722608143 0.025491424827976 no 207 0.0266935040842894 292 44120435 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.93160044193951 0.0255014774127159 no 208 0.0267044206349388 268 140250 A respiratory chain inhibitor. SGTC_1051 3253-3903 78 µM 1.92984128050282 0.0256016906855443 no 209 0.0268132534409271 272 5509239 SGTC_3318 9139014 38.6185 µM 1.92872669892688 0.0256653549689446 no 210 0.026882399951592 213 16643984 SGTC_1863 st057641 20.1 µM 1.92103140819926 0.026108531366029 no 211 0.0273638739761991 252 3921635 SGTC_1995 st072814 61.1 µM 1.90730585955388 0.0269148800793069 no 212 0.0282404959357117 238 5769371 SGTC_1518 st038567 90.8 µM 1.90583914883025 0.0270022629377264 no 213 0.028335538982755 209 77966 SGTC_2850 9015429 58.44 µM 1.89924799437511 0.0273978751050515 no 214 0.0287659385411662 247 6457570 SGTC_2171 5739187 198.077 µM 1.89172884562092 0.0278550773672325 no 215 0.0292635589786397 203 2262761 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.88721243813486 0.028132740724429 no 216 0.0295658790063591 241 66535 A nucleotide analog. SGTC_1844 rapamycin 4 nM 1.87682672585379 0.0287799923825302 no 217 0.030270923109934 432 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2684 capsaicin 100 µM 1.87531062437318 0.0288755054795639 no 218 0.0303750012927876 242 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1182 1222-0449 220 µM 1.87487655466448 0.0289028999687638 no 219 0.0304048540929174 231 658318 SGTC_1702 st027038 51 µM 1.86835075542451 0.0293173586081175 no 220 0.0308565981548237 273 5521182 SGTC_1913 st060213 96.1 µM 1.85819376650721 0.0299722478111546 no 221 0.0315707514534621 306 688959 SGTC_2289 7946404 165.07 µM 1.85581706654854 0.0301272286345174 no 222 0.0317398185601439 365 1246120 YPR165W RHO1 SGTC_2329 6138490 200 µM 1.85553811873597 0.0301454618631273 no 223 0.0317597105379155 251 720019 SGTC_1620 st003704 16.5 µM 1.85465702109328 0.0302031142852019 no 224 0.0318226099300884 212 2834414 SGTC_2948 9070189 9.45 µM 1.85363007931581 0.0302704249597436 no 225 0.0318960506051294 253 6473636 YDL196W YDL196W SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.85362694166409 0.0302706308067895 no 226 0.0318962752053624 237 1609 A potent and irreversible inhibitor of serine proteases. SGTC_500 h-89 112 µM 1.84795793485547 0.0306444477589849 no 227 0.0323042141856894 292 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3074 9116018 49.47 µM 1.84397487332236 0.030909372780429 no 228 0.0325934010613652 226 17027303 SGTC_2914 7968218 45.32 µM 1.84307328626996 0.0309696023267297 no 229 0.0326591555300519 204 2977111 SGTC_1596 piperlongumine 63 µM 1.83776840509317 0.0313259591667673 no 230 0.0330482695743839 271 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2655 perillic acid 100 µM 1.83661311158137 0.0314040142810748 no 231 0.0331335151632293 179 5702197 An apoptosis inducer. SGTC_1202 1988-0068 29.6 µM 1.83101993193686 0.0317841834315229 no 232 0.0335487840551968 285 2850480 SGTC_2635 hydroquinidine 100 µM 1.83014050219474 0.0318443028833114 no 233 0.0336144659460826 259 442912 An experimental heart treatment. SGTC_3291 9121177 71.43 µM 1.82160106166931 0.0324329734757477 no 234 0.0342577698674237 231 17015612 SGTC_1613 st002381 52.1 µM 1.81999546865348 0.0325446524522557 no 235 0.0343798474788713 286 551167 SGTC_2343 7990716 14.84 µM 1.81527564187282 0.032874783735828 no 236 0.0347407801658159 275 6456862 SGTC_3193 9111931 49.47 µM 1.81487356113532 0.0329030346689199 no 237 0.0347716712154393 278 17087244 SGTC_43 0570-0105 72.5 µM 1.81033317527757 0.0332234414879066 no 238 0.0351220676637388 443 1114046 YDL195W SEC31 SGTC_2922 7999257 32.47 µM 1.80706066029939 0.033455967106972 no 239 0.0353764107998449 236 2988377 SGTC_2995 9067767 71.4286 µM 1.8062950524555 0.0335105596446066 no 240 0.0354361321254379 246 11673567 SGTC_432 NS 1619 61.3 µM 1.80579073620835 0.0335465605347365 no 241 0.0354755165163664 273 4552 A K+/calcium channel activator. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.8023203581493 0.0337951595585848 no 242 0.0357475086668275 157 1241132 A phosphatase inhibitor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.80222493574836 0.03380201645395 no 243 0.0357550115058271 320 5379071 SGTC_2375 9072683 200 µM 1.79475936917706 0.0343420380547289 no 244 0.0363460234627968 312 16798029 SGTC_2496 diffractaic acid 79.83 µM 1.79340123283553 0.0344410370137436 no 245 0.0364543953027181 305 94870 An apoptosis inducer which activates caspases. SGTC_2197 6588183 93.1375 µM 1.78197185189991 0.0352834846835909 no 246 0.0373769110310946 217 884136 SGTC_3165 9101544 49.47 µM 1.77738940857831 0.035625965055598 no 247 0.0377520960925316 293 5002184 SGTC_257 daunorubicin 18.5 µM 1.77548095242561 0.0357693997721226 no 248 0.0379092539427809 239 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2732 terfenadine 20 µM 1.77458724408628 0.0358367311257461 no 249 0.0379830324893887 222 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1848 st056003 16.4 µM 1.77024728486588 0.0361651786758445 no 250 0.0383429777257065 288 146492 SGTC_401 neomycin 50 µM 1.7679791566552 0.03633780856506 no 251 0.0385321941236792 253 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2191 5911152 200 µM 1.76454539383406 0.0366004392348895 no 252 0.0388200999016946 286 2875902 SGTC_3132 9126706 49.47 µM 1.76358391343775 0.0366742555183457 no 253 0.0389010290187284 285 850858 SGTC_405 ebelactone b 50 µM 1.76092975279822 0.036878657151831 no 254 0.0391251466945221 305 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_865 0488-0499 301 µM 1.75899724291277 0.0370280684202894 no 255 0.0392889884296385 299 9634651 SGTC_2172 5754775 163.918 µM 1.7545271365391 0.0373755694104286 no 256 0.0396701121289973 300 2263357 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.75097600305059 0.0376535252470201 no 257 0.0399750218228121 251 17037758 SGTC_540 1187-0821 17.3 µM 1.75004622386708 0.0377265794213808 no 258 0.0400551689537975 296 847520 SGTC_2805 7950783 58.44 µM 1.74623930680555 0.0380269022645107 no 259 0.0403846886455537 355 1178958 YDL195W SEC31 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.74606000959233 0.0380410947461853 no 260 0.0404002623984887 302 165521 SGTC_767 0929-0023 86 µM 1.74447811811248 0.0381664985504766 no 261 0.0405378768818113 426 1204563 SGTC_2791 5663188 71.43 µM 1.73900121936979 0.0386032841603379 no 262 0.0410172742195205 304 54690634 SGTC_2941 9056145 11.23 µM 1.73584470399422 0.0388568626245207 no 263 0.0412956486277637 223 2119517 SGTC_593 1203-0218 61.7 µM 1.73358293353092 0.039039394822375 no 264 0.0414960553785048 296 3666956 SGTC_1177 0983-0204 23.6 µM 1.73354790261687 0.0390422274110157 no 265 0.0414991655188981 309 766818 SGTC_2821 7996764 71.43 µM 1.72975001869313 0.039350316959506 no 266 0.0418374739288464 359 2987135 SGTC_409 arachidonic acid 100 µM 1.72968616368358 0.0393555138259993 no 267 0.0418431810468432 298 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2207 7258803 200 µM 1.71761279988741 0.0403481896668934 no 268 0.0429336320296946 257 3666799 SGTC_3120 9124077 49.47 µM 1.71424879614242 0.0406283723555165 no 269 0.0432415213184275 273 18774327 YGL155W CDC43 SGTC_2725 haloperidol 53.21 µM 1.71385365760539 0.0406613862230819 no 270 0.0432778029684812 335 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2001 4023502 57.655 µM 1.70882398369436 0.0410835213909305 no 271 0.0437417793515591 338 108941 YCR052W RSC6 SGTC_945 3381-0768 11.3 µM 1.70808748492139 0.0411456321889938 no 272 0.0438100553698625 335 1126236 YIL048W NEO1 SGTC_414 piperonyl butoxide 100 µM 1.70602251433132 0.0413201824439345 no 273 0.0440019439101619 285 5794 A potent inhibitor of cytochrome P450. SGTC_475 α-linolenic acid 10 µM 1.69808772884164 0.0419964952077878 no 274 0.0447456026331814 346 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.69003963523888 0.0426915913819801 no 275 0.0455101860685614 334 3256 An antibiotic and ribosome inhibitor. SGTC_1714 st033236 13.627 µM 1.68753413356715 0.0429098746939262 no 276 0.0457503461344816 344 2916566 SGTC_687 k029-0044 34.9 µM 1.6865155255634 0.0429988749269478 no 277 0.0458482736366232 328 5829338 SGTC_1804 st050076 49.1 µM 1.68539510653047 0.043096943023739 no 278 0.0459561835701296 326 3895976 SGTC_3050 9093513 49.47 µM 1.68237938633803 0.0433618009932573 no 279 0.0462476480027764 303 25236664 SGTC_1021 4476-0760 85.3 µM 1.67747992688063 0.0437949003713503 no 280 0.0467243357349264 350 746768 SGTC_2866 9034245 58.44 µM 1.67009704953472 0.0444541119102129 no 281 0.047450081910017 284 6462273 SGTC_209 4077-0173 175.592 µM 1.66108872305078 0.0452692621686478 no 282 0.0483478144890999 232 15993494 SGTC_2749 bexarotene 57.39 µM 1.66017724762165 0.0453524058540138 no 283 0.0484394001948624 369 82146 An retinoic acid receptor inhibitor. SGTC_1805 st050013 60.3 µM 1.65474700481089 0.0458502948640593 no 284 0.0489879139691216 292 4037144 SGTC_1288 0973-0013 65.5 µM 1.64996135832101 0.0462927146562233 no 285 0.0494754198480137 351 4315430 SGTC_853 0419-0306 21 µM 1.64735440243499 0.0465351589065698 no 286 0.0497426109239007 313 762713 SGTC_103 0844-0104 51.839 µM 1.64629371417093 0.0466340930379302 no 287 0.0498516515020623 499 5375804 SGTC_211 3455-0679 143.504 µM 1.64352325474698 0.0468932998240979 no 288 0.0501373589830423 378 748649 SGTC_2887 9044784 58.44 µM 1.64078612448677 0.047150521805166 no 289 0.0504209097797883 365 6465546 SGTC_1329 1447-1697 50.6 µM 1.63826723963189 0.0473882323861265 no 290 0.0506829792460777 358 2840515 SGTC_562 3772-2733 112 µM 1.63634938315782 0.0475698662518253 no 291 0.0508832431252379 430 2876874 YIL048W NEO1 SGTC_249 wiskostatin 11.211 µM 1.62459586358202 0.0486952159630711 no 292 0.0521243495491049 336 2775510 A n-wasp and actin depolymerizer. SGTC_3022 9087993 49.47 µM 1.61839252235261 0.0492976828727808 no 293 0.0527890162438085 298 17173644 SGTC_668 1682-0499 62.6 µM 1.61604356379548 0.0495273607631661 no 294 0.0530424473664321 430 682214 SGTC_3051 9093778 49.47 µM 1.61426952258182 0.0497013894748043 no 295 0.0532344889141351 270 17217378 SGTC_2958 9077254 16.72 µM 1.61416777407188 0.0497113855073352 no 296 0.053245519971872 336 16457351 SGTC_1489 4065-0444 182 µM 1.61367019847205 0.0497602917040702 no 297 0.0532994906952967 334 2877968 SGTC_234 nsc-17383 10.7 µM 1.60913965204878 0.0502073623660313 no 298 0.0537929042867127 422 408974 SGTC_1631 benzylvanillin 81.9 µM 1.60869507549784 0.0502514047840841 no 299 0.0538415165678063 390 75506 SGTC_3277 9138724 49.47 µM 1.60743630773649 0.0503762729062319 no 300 0.0539793453893303 263 15943418 SGTC_273 hydroxyurea 18.1 mM 1.59849710865736 0.0512701568683117 no 301 0.0549661941875454 432 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1117 retinoic acid 1.10837 µM 1.59746649587708 0.0513740202653424 no 302 0.0550808801293816 401 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2540 epiandrosterone 100 µM 1.59626390475147 0.0514954268520346 no 303 0.0552149426288895 507 441302 A steroid. SGTC_1565 sinapyl alcohol 95.1 µM 1.59459940700461 0.0516638411505763 no 304 0.0554009226518076 360 5280507 A phenol propionate derived from cinnamic acid. SGTC_11 0438-0307 1.3 µM 1.59230916170361 0.0518962841468836 no 305 0.0556576276950573 339 4011476 SGTC_1135 dihydrocapsaicin 536.708 nM 1.58948924641534 0.0521836254408164 no 306 0.0559749899746498 391 107982 A Capsaicinoid. SGTC_2425 5628681 7.85 µM 1.5892185975173 0.0522112701169854 no 307 0.0560055245887465 445 5714958 SGTC_1830 st055982 50.3 µM 1.58792296353188 0.052343770180082 no 308 0.0561518800647133 395 455313 An antimicrobial agent. SGTC_321 4534-3890 65.3 µM 1.58701700844252 0.0524365776229918 no 309 0.0562543962585903 344 699746 SGTC_1499 4480-0877 67.3 µM 1.58622319753979 0.0525180041755219 no 310 0.0563443436631876 301 2861909 SGTC_519 k048-0011 62.8 µM 1.58454191658258 0.0526907959179147 no 311 0.0565352253843543 380 6836379 SGTC_2331 7980721 200 µM 1.58198283829309 0.052954667823281 no 312 0.0568267441644718 391 2981221 SGTC_1286 0929-0070 131 µM 1.57722518113264 0.05344802434463 no 313 0.0573718604261259 411 1420408 SGTC_3076 9116187 49.47 µM 1.57591916764228 0.0535840897166232 no 314 0.0575222164991437 348 27241210 SGTC_1335 1486-0900 202 µM 1.57301037338262 0.0538881249717177 no 315 0.0578582081335112 424 X1335 SGTC_2713 st079149 53.4 µM 1.57159573670983 0.0540364795729557 no 316 0.0580221679128568 396 3103253 SGTC_1515 3460-0031 42.1 µM 1.5685270861669 0.0543594037414333 no 317 0.0583790868914051 319 2876596 SGTC_1268 0828-0275 2.46 µM 1.56597272315641 0.0546293704178174 no 318 0.058677501520267 376 745337 SGTC_1575 cyproterone acetate 48 µM 1.56584634862553 0.0546427542191665 no 319 0.0586922963103247 379 9880 An androgen receptor antagonist and liver toxin. SGTC_180 1486-1293 102.781 µM 1.56459888849373 0.0547750066859514 no 320 0.0588384948423831 379 4140536 SGTC_2965 9082772 38.63 µM 1.56118543103104 0.0551381862273935 no 321 0.0592400027349666 412 16459634 SGTC_101 0490-5701 117.494 µM 1.55862337487564 0.0554120274228102 no 322 0.0595427736266479 330 4661669 SGTC_960 1222-0186 7.7 µM 1.55705884506555 0.0555797770236615 no 323 0.0597282574675766 397 3126296 SGTC_1154 4088-0362 150 µM 1.55560380060095 0.0557361470736934 no 324 0.0599011672099625 460 6618304 SGTC_1654 st012436 41.8 µM 1.55377437313331 0.0559332435545544 no 325 0.0601191227121748 341 4323132 SGTC_473 2-arachidonoylglycerol 10 µM 1.55315043991246 0.0560005896551145 no 326 0.0601935990982903 387 5282280 An endocannabinoid. SGTC_1062 mesoridazine 14.2 µM 1.55309074696755 0.0560070361426366 no 327 0.0602007281877147 407 4078 A neuroleptic. SGTC_390 dec-rvkr-cmk 16.7 µM 1.5515492919293 0.0561737070314367 no 328 0.0603850521666431 418 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2450 5739737 12.93 µM 1.55029944993435 0.0563091339635838 no 329 0.0605348296538857 375 2262825 SGTC_841 0251-0215 91.2 µM 1.54958695108258 0.0563864520557701 no 330 0.0606203434597191 471 3888614 SGTC_1212 0520-0165 585 µM 1.54514344943899 0.0568705364634519 no 331 0.0611557846626908 417 5403258 SGTC_3323 9138564 53.9225 µM 1.54262470841013 0.0571463832893 no 332 0.0614609297232378 446 43912313 YNL103W MET4 SGTC_973 1325-0077 65.9 µM 1.53834537811634 0.0576174593229951 no 333 0.0619820950061733 428 2835149 SGTC_17 0960-0276 49.807 µM 1.53806716886812 0.0576481904905766 no 334 0.0620160962029503 446 6821114 SGTC_3348 9149464 3.537 µM 1.535489329985 0.057933553599057 no 335 0.0623318380167119 391 1951442 SGTC_1606 st000094 49.2 µM 1.53000100760743 0.0585448007127963 no 336 0.0630082397597677 414 1242210 SGTC_2189 6047310 154.431 µM 1.52683957174745 0.0588991887891931 no 337 0.0634004544314336 382 711535 SGTC_1835 st008666 49.2 µM 1.5253642472158 0.0590651435252289 no 338 0.0635841355741396 342 690455 SGTC_3274 9138298 49.47 µM 1.52305788463877 0.0593253138149185 no 339 0.0638721121070328 436 17015756 SGTC_1078 idebenone 36.1 µM 1.52231937162864 0.0594088117674792 no 340 0.0639645382514096 470 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_907 3448-6986 75.5 µM 1.51926017041589 0.0597556735937723 no 341 0.0643485105205422 459 590582 SGTC_1959 st077091 55.8 µM 1.51510178835537 0.0602297057557371 no 342 0.0648733144328805 442 821356 YKL052C ASK1 SGTC_1371 2421-0008 32.7 µM 1.51268682185453 0.0605063464877504 no 343 0.0651796142730138 430 2827552 SGTC_1965 Pectolinarigenin 58.4 µM 1.511490500932 0.0606437559049649 no 344 0.0653317634872523 395 5320438 An anti-inflammatory. SGTC_2827 7993847 71.43 µM 1.50880468773711 0.0609531374966524 no 345 0.0656743512273335 358 2985692 SGTC_2319 6033012 152.6 µM 1.50802718789134 0.0610429284260037 no 346 0.0657737843837785 349 847246 SGTC_2322 7413319 38.22 µM 1.50497805540468 0.0613960609602921 no 347 0.0661648593545157 596 1840400 SGTC_1807 st050092 58.9 µM 1.50048114771048 0.0619197760802608 no 348 0.0667449066590267 405 5008496 SGTC_927 2425-1185 123 µM 1.49690351378063 0.0623389164615797 no 349 0.0672091829026308 398 730375 SGTC_2844 9010103 25.97 µM 1.49249203887984 0.0628587885389465 no 350 0.0677851013713902 467 2480525 SGTC_2611 pyromycin 23.93 µM 1.48745571687283 0.063456418591237 no 351 0.0684472453429243 440 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1298 1079-1278 263 µM 1.4868562812472 0.0635278435359065 no 352 0.0685263865422849 451 2840950 SGTC_1391 3442-0225 151 µM 1.48677458349589 0.0635375829640565 no 353 0.0685371782483253 357 5227075 SGTC_599 1935-0052 86.5 µM 1.48323848279513 0.0639602464728609 no 354 0.0690055300821087 457 9557311 SGTC_766 1391-0721 126 µM 1.47696191605861 0.0647158535160663 no 355 0.0698429231145397 423 1020919 YIL115C NUP159 SGTC_2903 5923464 63.88 µM 1.47662602021255 0.0647564850612092 no 356 0.0698879564223775 392 2876576 SGTC_2463 5473429 200 µM 1.47506196616175 0.0649459413355488 no 357 0.0700979423087286 391 5399405 SGTC_891 0929-0073 133 µM 1.47494992972039 0.0649595289794208 no 358 0.0701130026424537 415 5603632 SGTC_1362 1611-0397 101 µM 1.47490822912085 0.0649645869410942 no 359 0.0701186088197504 431 27816 SGTC_2312 7706453 155.7 µM 1.47185717805562 0.0653354860500699 no 360 0.0705297246692776 436 976098 SGTC_2833 9001315 45.46 µM 1.47104589996972 0.0654343845038675 no 361 0.0706393520942278 467 2989378 SGTC_633 0437-0093 97.7 µM 1.46891284300459 0.0656949677385559 no 362 0.0709282153565116 409 2831118 SGTC_1068 loratadine 26.9 µM 1.46636540206008 0.0660072271509588 no 363 0.0712743833075505 422 3957 A H1 histamine antagonist. SGTC_2039 Aminomethylbenzodioxan 200 µM 1.4654602928919 0.0661184498040704 no 364 0.0713976890315029 378 15053 SGTC_1529 apigenin 74 µM 1.46214603376808 0.0665269557981533 no 365 0.071850598168547 482 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_862 0452-0056 10.2 µM 1.46198196294884 0.0665472293338814 no 366 0.0718730763260419 411 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1768 st044301 37.178 µM 1.45791369303494 0.0670514591694347 no 367 0.0724321669188618 454 3931349 SGTC_289 k017-0060 526 µM 1.45701880270396 0.0671627691916345 no 368 0.0725555950124095 393 5512909 SGTC_834 0312-0008 75.7 µM 1.45180643696395 0.0678139459515785 no 369 0.073277716798499 483 6385573 YIL048W NEO1 SGTC_2938 9059746 27.26 µM 1.4504196308465 0.0679880172023621 no 370 0.0734707680415727 416 6471769 SGTC_2043 5101342 149 µM 1.45018536769037 0.0680174558346683 no 371 0.0735034171608908 459 678451 SGTC_556 4058-0063 51.5 µM 1.44909204229399 0.0681549785151911 no 372 0.0736559400210385 486 6615692 SGTC_1081 sertraline 6 µM 1.44790266874167 0.0683048261343251 no 373 0.0738221365932828 508 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_112 phenothiazine 287.218 µM 1.44776366534597 0.0683223555705675 no 374 0.0738415788599467 446 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2295 7971645 200 µM 1.44336539994216 0.0688788064832781 no 375 0.0744587827676721 462 2978226 YKL099C UTP11 SGTC_1388 3346-4487 254 µM 1.44281774326916 0.0689483377136003 no 376 0.0745359097681318 503 3345614 SGTC_2526 patulin 37.61 µM 1.44198780815748 0.0690538104993125 no 377 0.0746529065153844 540 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_482 fipronil 114 µM 1.44022877569643 0.069277769180511 no 378 0.0749013422626816 338 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2867 9039098 71.43 µM 1.43966127037899 0.0693501427878651 no 379 0.0749816279018943 468 6463460 SGTC_1455 4262-0120 131 µM 1.43476694911541 0.0699767316761893 no 380 0.075676759528165 453 1529587 SGTC_1947 st076332 61.6 µM 1.43142843596765 0.0704066331916931 no 381 0.0761537317621395 376 24208416 SGTC_404 fumagillin 50 µM 1.43019754919468 0.0705656462664212 no 382 0.0763301643324134 490 12015870 A methionine aminopeptidase binder. SGTC_1539 benzyladenosine 56 µM 1.42538642259103 0.0711898245469032 no 383 0.0770227653130091 428 92208 A nucleotide analog. SGTC_2403 6032726 181.2 µM 1.41903893255713 0.0720198000303454 no 384 0.0779438329544406 459 2881040 SGTC_2443 5493264 126.67 µM 1.41617279938056 0.0723969880526813 no 385 0.0783624588589614 461 5340055 SGTC_1223 0764-0573 147 µM 1.4161156812178 0.0724045202529617 no 386 0.0783708187999242 513 1609797 SGTC_2393 9031399 185.94 µM 1.41300293126796 0.0728159087166181 no 387 0.0788274311118943 475 1526623 YDL150W RPC53 SGTC_2040 5100729 123 µM 1.41283049261172 0.0728387508288747 no 388 0.0788527851042705 475 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_650 1328-0195 38 µM 1.41117225903792 0.0730586890924334 no 389 0.0790969138763736 488 2780821 SGTC_2908 7930301 100 µM 1.40602342609374 0.073744839228537 no 390 0.0798585843158749 507 2223178 SGTC_102 gallobenzophenone 83.616 µM 1.40500024756215 0.0738817761151712 no 391 0.0800106023282082 499 70837 SGTC_1780 st038448 24.544 µM 1.39898700907866 0.0746904864477531 no 392 0.0809084393720793 469 728868 YDL195W SEC31 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.39593426384826 0.0751036217422678 no 393 0.0813671457298364 515 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_601 0986-0029 62.9 µM 1.39236059731706 0.0755894659322571 no 394 0.0819066150020981 531 24747981 SGTC_3011 9081274 71.4286 µM 1.39079730428972 0.0758027488442264 no 395 0.0821434503971886 519 6625322 SGTC_1097 itavastatin 7.23 µM 1.3884110861754 0.076129188275085 no 396 0.0825059512368754 491 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2146 5545642 200 µM 1.38558151891963 0.0765176642694498 no 397 0.0829373623391647 477 825326 SGTC_2810 7959871 45.46 µM 1.38433939942351 0.0766886724336492 no 398 0.0831272776536568 561 2974535 SGTC_2800 7887935 81.82 µM 1.38415544130844 0.0767140234624731 no 399 0.0831554319257243 469 2961002 SGTC_3354 9151612 71.43 µM 1.38221910058143 0.0769812547600987 no 400 0.0834522185203495 521 27261949 SGTC_1324 1418-0026 34.4 µM 1.37686013595254 0.0777245255782925 no 401 0.084277747061755 512 1372513 SGTC_2531 methyl deoxycholate 70.07 µM 1.37626026855616 0.077808063087565 no 402 0.0843705344854201 484 16667744 Haematoxylin. SGTC_1761 st044296 37 µM 1.37439671761934 0.078068015814197 no 403 0.0846592773113759 492 1826700 SGTC_1131 3454-3128 32.3 µM 1.37060336559491 0.0785991975499182 no 404 0.085249316620851 553 710982 SGTC_467 ro 31-8220 72.8 µM 1.36875795866079 0.0788585976467845 no 405 0.0855374732333272 536 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3093 9117344 49.47 µM 1.36687744391352 0.0791235993550338 no 406 0.0858318615742511 479 24824913 SGTC_2274 7947094 46.08 µM 1.3614553237783 0.0798914584959374 no 407 0.0866849214563909 519 2971028 SGTC_539 4859-0462 2.54 µM 1.35631046812169 0.0806252503344645 no 408 0.0875002031018616 496 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1002 4049-0206 172 µM 1.34614632159345 0.0820898700483621 no 409 0.0891276661916795 564 4662749 SGTC_1221 2958-7315 257 µM 1.3451700345298 0.0822315980803274 no 410 0.0892851653632954 514 4562705 SGTC_757 1066-0008 322 µM 1.34493149761063 0.0822662545912293 no 411 0.0893236787074534 548 6842497 SGTC_3305 9127027 53.8275 µM 1.34228280771922 0.0826518165059273 no 412 0.0897521578357011 513 41905295 SGTC_682 0kpi-0099 17 µM 1.34161471652082 0.0827492830007816 no 413 0.0898604760074071 560 1714895 YML126C ERG13 SGTC_2261 9010538 184.68 µM 1.33467184312889 0.0837672898974758 no 414 0.0909918864778835 433 6457250 SGTC_154 3389-1638 511.116 µM 1.3346565508467 0.0837695424826606 no 415 0.0909943901173915 461 5238686 SGTC_41 0478-0632 82.643 µM 1.33450764584753 0.0837914788794548 no 416 0.0910187713892807 611 3750424 SGTC_389 tpck 16.7 µM 1.33314488226054 0.0839924390576867 no 417 0.0912421314836126 519 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1428 4049-0204 61.7 µM 1.33186273462313 0.0841818414040382 no 418 0.0914526492631254 539 X1428 SGTC_2647 atorvastatin 60.16 µM 1.33044549946772 0.0843915720844474 no 419 0.0916857659356459 505 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1501 4491-0275 38.4 µM 1.32454049987791 0.0852696495206558 no 420 0.092661800891607 509 5104718 SGTC_992 3909-8734 162 µM 1.31864271927577 0.0861534680590735 no 421 0.0936442924459406 521 4288319 SGTC_2931 9014674 55.67 µM 1.31178601594481 0.0871895809021645 no 422 0.0947961722755312 518 2996810 SGTC_1033 k072-0102 21.3 µM 1.31066312572862 0.0873601432053095 no 423 0.0949858009391014 552 5965931 SGTC_1616 st002734 56.1 µM 1.30972838589184 0.0875023161225546 no 424 0.095143868615784 556 4026101 SGTC_89 0302-0250 142.109 µM 1.30578318900439 0.0881042790668715 no 425 0.0958131492583126 588 4203518 YLR208W SEC13 SGTC_295 k015-0027 31 µM 1.30534035896482 0.0881720388623835 no 426 0.0958884885453004 528 3887424 SGTC_2348 9022543 33.42 µM 1.30452972728713 0.0882961785875595 no 427 0.0960265153006064 556 3162678 YDL140C RPO21 SGTC_2093 5331342 194.4 µM 1.30202703039316 0.0886802621705029 no 428 0.0964535727600947 550 33839 SGTC_2680 butyl paraben 22.24 µM 1.29854683710063 0.0892164264072253 no 429 0.0970497463455395 488 7184 An antifungal and steroid mimetic. SGTC_66 0109-0187 42.4 µM 1.29780922991625 0.0893303725166765 no 430 0.0971764485886635 515 759417 SGTC_1227 3909-8010 46.6 µM 1.29717246331107 0.0894288277432932 no 431 0.0972859265673738 529 15982272 SGTC_3108 9121785 49.47 µM 1.29626261767602 0.0895696457752007 no 432 0.0974425114515276 537 17140271 SGTC_1934 st074720 32.6 µM 1.29573901069244 0.0896507598473853 no 433 0.0975327082372075 602 17250992 SGTC_115 0527-0192 112.043 µM 1.29390631241803 0.089935100683111 no 434 0.0978488919220352 650 4233931 SGTC_3293 9120939 62.045 µM 1.29157574758912 0.0902976522204765 no 435 0.0982520536801786 542 934087 SGTC_1990 st072050 59.8 µM 1.28758284570164 0.090921324362406 no 436 0.0989456069582449 560 17233948 SGTC_2566 crystal violet carbinol 226 nM 1.28434613785316 0.0914292233329902 no 437 0.0995104350436084 501 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1847 st056231 15 µM 1.28207950359143 0.0917861499127353 no 438 0.0999073790939728 613 5393180 SGTC_2625 euphol 100 µM 1.28119691742422 0.0919254094839906 no 439 0.100062254298458 608 6708538 A triterpene alcohol. SGTC_1770 st043884 66.3 µM 1.27953496997544 0.0921880658461796 no 440 0.100354366628766 563 670149 SGTC_1880 MG-132 525 µM 1.27816217015578 0.0924054435748132 no 441 0.100596125851016 513 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1390 3413-2614 145 µM 1.27710881379698 0.0925724956204246 no 442 0.100781916806819 590 3421432 SGTC_1797 st048695 56.8 µM 1.27596899746405 0.0927535109244576 no 443 0.10098323931269 560 592262 YIL048W NEO1 SGTC_1644 st010134 20.9 µM 1.27528719366653 0.0928619138701589 no 444 0.101103804416712 525 3818134 SGTC_676 falcarinol 140 µM 1.2752771938234 0.0928635044853588 no 445 0.101105573494763 582 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1020 4335-0961 93.3 µM 1.27319937081083 0.0931944484832323 no 446 0.10147365190065 525 669075 SGTC_2115 tiliquinol 12.7705 µM 1.2717936802579 0.0934188327179401 no 447 0.101723217491996 524 71208 A bioactive hydroxyquinoline. SGTC_1312 1218-2183 165 µM 1.27141793843139 0.0934788782788769 no 448 0.101790002129671 584 6744073 SGTC_139 0099-0334 718.624 µM 1.26844171803553 0.0939555017046966 no 449 0.102320125768196 649 97690 SGTC_809 3998-0021 90 µM 1.26569137966909 0.0943975437289882 no 450 0.102811797884203 532 715485 SGTC_2961 9083290 32.55 µM 1.26488242205107 0.0945278530630353 no 451 0.102956739721522 525 17741490 SGTC_958 1222-0007 33 µM 1.26430914265385 0.0946202788968357 no 452 0.103059544664029 628 7312461 SGTC_159 3970-0959 50 µM 1.26359307655355 0.0947358187798082 no 453 0.103188059937553 786 6615653 SGTC_634 1611-4317 11.2 µM 1.26311970538118 0.0948122560154702 no 454 0.103273081643453 621 2843522 SGTC_2057 5236571 38.335 µM 1.2614678896799 0.0950793376190612 no 455 0.103570160943148 611 54684039 YBR257W POP4 SGTC_739 1486-1183 203 µM 1.25996186199299 0.0953233293629966 no 456 0.10384156028327 589 4346692 SGTC_1686 st019653 115.5 µM 1.25975434996094 0.0953569845158696 no 457 0.103878996161968 567 97252 SGTC_2369 9071472 200 µM 1.25957214740649 0.0953865420853596 no 458 0.103911874194229 575 17296037 SGTC_471 1-acyl-paf 4 µM 1.25539722889709 0.0960656616646891 no 459 0.104667297405443 567 16759367 SGTC_1891 st059073 26.2 µM 1.24782387137375 0.0973066555601087 no 460 0.106047782334581 628 688754 SGTC_1964 st076914 61 µM 1.24628470598498 0.0975602997259554 no 461 0.106329945333779 569 24208661 SGTC_1792 st045773 43.6 µM 1.24327980703831 0.098056883670818 no 462 0.106882371317592 579 2919270 SGTC_1293 1000-1278 195 µM 1.24107074392007 0.0984231287592076 no 463 0.107289808043154 601 678847 SGTC_48 0382-0018 55 µM 1.23891345575841 0.0987817557296308 no 464 0.107688774999942 551 762596 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.23849229463144 0.0988518808624104 no 465 0.107766788707494 508 4620898 SGTC_1955 wogonin 32.4 µM 1.23712729866671 0.0990794088715829 no 466 0.108019913270926 559 5281703 A flavanone. SGTC_2517 totarol 10 µM 1.23662073254895 0.0991639445810224 no 467 0.108113959612937 538 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1381 2324-0066 62.1 µM 1.23499911299348 0.0994349149851534 no 468 0.108415417128617 578 10885928 SGTC_1723 st034307 2.5525 µM 1.23484648484342 0.0994604467804854 no 469 0.108443821665421 583 867466 SGTC_1730 st033808 45.1 µM 1.23018046799633 0.100243296870829 no 470 0.109314766175118 663 1045166 SGTC_2921 7974240 10.71 µM 1.22819107635956 0.100578435054035 no 471 0.109687623888198 598 2979074 YDR527W RBA50 SGTC_1893 st059353 36.1 µM 1.22810908912855 0.100592264355794 no 472 0.109703009744566 601 3112488 SGTC_2079 5212404 121 µM 1.22290890238675 0.101472248850225 no 473 0.11068205287655 585 758462 SGTC_2818 7996756 12.99 µM 1.2215330327052 0.101706011096888 no 474 0.110942133263765 511 2241621 SGTC_2049 5262831 67.185 µM 1.22025383100517 0.101923700809707 no 475 0.111184332966743 611 763417 SGTC_3129 9127257 49.47 µM 1.21949424991363 0.102053123804258 no 476 0.111328328492393 518 837894 SGTC_2395 5646831 180.19 µM 1.2184544869729 0.102230480051905 no 477 0.111525655099054 601 6808628 SGTC_3001 9076041 71.4286 µM 1.21212985645124 0.103314127070222 no 478 0.112731338263511 591 16004211 SGTC_2839 9003951 25.97 µM 1.21204518609245 0.103328690638943 no 479 0.112747542115197 573 2990634 SGTC_56 0957-0365 83.25 µM 1.21013406797283 0.103657805551301 no 480 0.113113726228297 625 6752360 SGTC_1395 3486-0190 4.35 µM 1.20769866257846 0.104078309651795 no 481 0.113581596331336 654 6748079 SGTC_1018 4259-0013 28.1 µM 1.20762714296677 0.104090677099895 no 482 0.113595356916045 589 6801262 SGTC_1624 st003710 6.25 µM 1.20711119107032 0.104179929069486 no 483 0.113694662803247 666 24207033 SGTC_2260 7964312 200 µM 1.20485157588218 0.104571462249595 no 484 0.114130302632321 561 231951 SGTC_1862 st057513 3.81 µM 1.20324550435751 0.10485040047563 no 485 0.11444066529741 595 5393163 SGTC_1972 st070201 17.4 µM 1.20214219762315 0.10504233176137 no 486 0.11465421984909 628 2829099 SGTC_2430 5571206 200 µM 1.20133341813745 0.105183188519108 no 487 0.114810946138285 690 1731771 SGTC_382 3229-0966 23.2 µM 1.20090397463073 0.105258035784247 no 488 0.114894226153658 662 5722370 SGTC_1944 st076371 56.9 µM 1.20059740156077 0.105311491657492 no 489 0.11495370474802 597 24208455 SGTC_2916 7875993 68.79 µM 1.20029964469107 0.105363429085356 no 490 0.115011493862092 627 1299250 SGTC_3156 9099931 49.47 µM 1.19785179773802 0.105791106978245 no 491 0.11548735895985 654 18111053 SGTC_1437 4092-1038 11.6 µM 1.19705300517769 0.105930939966409 no 492 0.115642947761355 657 3977136 SGTC_2448 5185112 27.17 µM 1.19595842692106 0.106122768701987 no 493 0.115856391427355 559 5718189 SGTC_2957 9076800 11.52 µM 1.19259057463926 0.106714570520208 no 494 0.116514879489219 562 16459615 SGTC_3167 9103034 49.47 µM 1.19185929870116 0.106843385058315 no 495 0.116658209852026 556 5127859 SGTC_2341 7987486 176.74 µM 1.18831785503296 0.107468799070581 no 496 0.117354102921572 654 1258686 SGTC_3216 9129716 49.47 µM 1.18397980093654 0.108238483415765 no 497 0.118210529358859 581 8056934 SGTC_648 0375-0473 33.3 µM 1.18282097608582 0.108444759130259 no 498 0.118440052753174 667 1713139 SGTC_2384 9036245 200 µM 1.18120361010246 0.10873312973523 no 499 0.118760923745195 647 6462766 SGTC_2709 st078560 56 µM 1.17671630041533 0.109536087394282 no 500 0.119654379780403 641 17250903 SGTC_428 3448-4153 16.5 µM 1.17375025784238 0.110069162134901 no 501 0.120247536622118 560 3834874 SGTC_2347 9049783 174.81 µM 1.1723099012511 0.110328701873112 no 502 0.120536328912205 692 6467988 YPL169C MEX67 SGTC_32 0928-0142 34.1 µM 1.16951935764917 0.110832781699678 no 503 0.121097223365591 606 2244242 SGTC_1929 genistein trimethyl ether 50.5 µM 1.16834694974581 0.111045055311916 no 504 0.121333422225954 644 136420 SGTC_847 0342-0274 5.54 µM 1.16425538346539 0.111788146188909 no 505 0.12216026589376 668 18097 SGTC_2377 9073351 62.6 µM 1.15534939169811 0.11341789054803 no 506 0.123973688678506 645 7337946 YHR072W ERG7 SGTC_65 0798-0905 34.986 µM 1.15524253067393 0.113437547832349 no 507 0.123995561311903 757 3602145 SGTC_2872 9044037 25.97 µM 1.15479486879413 0.113519922477183 no 508 0.124087219433535 599 6465195 SGTC_2967 9089538 49.85 µM 1.15474362849768 0.113529353967693 no 509 0.124097713832893 678 728216 SGTC_2853 9015042 58.44 µM 1.14912714028341 0.114566536134277 no 510 0.125251779334902 616 6457456 SGTC_274 sirtinol 40.1 µM 1.14549472840921 0.115240905064547 no 511 0.126002138955276 678 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2978 9011784 42.97 µM 1.1451101919822 0.115312460318685 no 512 0.126081757029417 780 2994934 SGTC_2555 cholic acid 100 µM 1.13679813695311 0.116866907733324 no 513 0.127811341184855 668 6708657 Influences liver metabolism. SGTC_2084 5306078 60.6385 µM 1.13666446639296 0.116892026389542 no 514 0.127839289605943 656 679340 SGTC_2239 6685329 187.64 µM 1.13617183422434 0.116984632227655 no 515 0.127942327945828 664 805680 SGTC_2483 5729050 27.16 µM 1.13479397754928 0.117243920115186 no 516 0.128230825097113 777 2865180 SGTC_29 0299-0004 12.984 µM 1.1276974260185 0.11858581113095 no 517 0.12972386254568 569 16871 A napthoquinone isolated from Swertia calycina. SGTC_2000 st075254 36.4 µM 1.12349192710014 0.119386134084621 no 518 0.130614313647046 646 17234175 SGTC_3179 9107801 49.47 µM 1.11873907338728 0.120295199623017 no 519 0.131625735327441 687 4818259 SGTC_1157 4092-0394 27.6 µM 1.11832471306986 0.120374683683961 no 520 0.131714167920172 754 3659885 SGTC_2481 5478948 45.16 µM 1.11690449543187 0.120647395512067 no 521 0.132017581155993 663 77792 SGTC_1165 k072-0275 30.3 µM 1.11655216039387 0.120715118580806 no 522 0.132092928066649 680 6153523 YGL055W OLE1 SGTC_2832 7992762 51.95 µM 1.11504246743685 0.121005602856584 no 523 0.132416111877952 584 2985177 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.11412453167696 0.121182465703711 no 524 0.132612882893764 672 6708514 SGTC_1922 5578187 25 µM 1.11085579935159 0.121813743399887 no 525 0.133315211861347 661 1350412 SGTC_153 4077-0274 519.67 µM 1.11013841687706 0.12195259732838 no 526 0.133469692487883 656 3121976 SGTC_1086 cerivastatin 2.18 µM 1.10866370112714 0.122238386986986 no 527 0.133787643293385 670 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2423 st077119 87.2 µM 1.10487022389405 0.122975695718424 no 528 0.134607913166949 701 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3147 9097027 49.47 µM 1.10014523190557 0.123898408616399 no 529 0.135634424386808 741 25236841 SGTC_71 0417-1750 47.813 µM 1.09962789963068 0.123999728612045 no 530 0.135747140412246 750 6811472 SGTC_3225 9130819 49.47 µM 1.09478925824134 0.124950188618448 no 531 0.136804486744897 708 4547121 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.0936803187854 0.125168733874444 no 532 0.137047604516611 714 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1999 st074831 12.5 µM 1.092711482557 0.125359886514082 no 533 0.137260248307486 725 17112523 SGTC_1719 st032227 49.2 µM 1.09134117596716 0.125630597568705 no 534 0.137561392896609 691 3125804 SGTC_1327 1436-0082 2.18 µM 1.09131125448533 0.125636513256977 no 535 0.13756797360035 706 15992205 SGTC_2598 perillyl alcohol 100 µM 1.08414594591816 0.127058744775388 no 536 0.139150046946193 739 10819 An apoptosis inducer. SGTC_2273 7815444 169.05 µM 1.08224191671809 0.127438549662106 no 537 0.139572523730946 695 2824616 SGTC_1597 7-benzyloxygramine 47.5 µM 1.08182077651838 0.127522662827478 no 538 0.139666086388368 822 260807 SGTC_1431 4049-0260 9.09 µM 1.08005545328114 0.127875665960834 no 539 0.140058743591429 739 3854841 SGTC_1865 st057639 52.2 µM 1.07880743868643 0.128125634734576 no 540 0.140336789043661 719 688818 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.07718849136348 0.128450404196383 no 541 0.140698032850133 701 688662 SGTC_2025 5147754 141 µM 1.07657010242969 0.128574607007531 no 542 0.140836183473209 722 315777 YLR208W SEC13 SGTC_2834 9001755 58.44 µM 1.07647276541812 0.128594164640372 no 543 0.140857937340996 654 2989575 SGTC_1696 st025591 34.7925 µM 1.07629305452096 0.128630278834527 no 544 0.140898106954039 749 2787147 SGTC_2315 7733312 200 µM 1.07322583930723 0.12924774304042 no 545 0.141584899946396 673 726316 SGTC_454 lyso-paf C-16 6.67 µM 1.0710921338469 0.129678491304304 no 546 0.142064002392217 698 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2061 5245884 80.95 µM 1.07033629271199 0.12983131724761 no 547 0.142233981956906 738 573863 SGTC_3227 9130768 49.47 µM 1.07007497064922 0.129884183793204 no 548 0.142292782143236 762 17720899 SGTC_525 k781-2675 26.7 µM 1.06962610003444 0.129975026978118 no 549 0.142393821091326 746 3651118 YDL195W SEC31 SGTC_3057 9095946 49.47 µM 1.06846501470888 0.130210213358301 no 550 0.142655401766476 750 24540043 SGTC_3269 9137823 49.47 µM 1.06492592224546 0.13092889856782 no 551 0.14345472669692 657 17682936 SGTC_1125 tnp00248 1.32998 µM 1.06479374573552 0.130955792709891 no 552 0.143484638000639 874 24207736 SGTC_3231 9132313 49.47 µM 1.0591213938489 0.132113552426038 no 553 0.144772248950641 741 4905967 SGTC_724 3910-0327 137 µM 1.05834877249502 0.132271793339917 no 554 0.144948232508684 760 2885483 SGTC_1587 estradiol valerate 56.1 µM 1.05805053021296 0.132332911406933 no 555 0.145016203050274 757 13791 A steroid. SGTC_1328 1441-0025 69.2 µM 1.05651675256865 0.132647532164875 no 556 0.145366095614859 701 4562601 SGTC_526 4469-0568 170 µM 1.05634689108595 0.132682407178307 no 557 0.145404880114271 722 2901964 SGTC_2588 indole-3-carbinol 100 µM 1.05327701696758 0.133313785270134 no 558 0.146107024610405 794 3712 Induces cell cycle arrest. SGTC_2786 7743617 45.45 µM 1.05223291558664 0.133528994918671 no 559 0.146346350657043 662 583674 SGTC_2374 9071832 200 µM 1.04994596670398 0.134001214122322 no 560 0.146871478018014 729 17381698 SGTC_339 3091-4833 71.4 µM 1.04513780409818 0.13499776339025 no 561 0.147979642000747 754 3240077 SGTC_590 k048-0076 22.4 µM 1.04312039365878 0.135417405884477 no 562 0.148446268290773 748 6832814 SGTC_1572 epiandrosterone 68.9 µM 1.04272640814643 0.135499463227113 no 563 0.148537511721262 808 441302 A steroid. SGTC_1037 k284-1091 78.7 µM 1.04245064544288 0.135556917977179 no 564 0.148601398138444 707 3334711 SGTC_2307 7538926 6.34 µM 1.04216223873517 0.135617024941764 no 565 0.148668233464303 761 96582 SGTC_120 rhodamine 6G 52.259 µM 1.03983820447908 0.136102044271939 no 566 0.149207538108018 908 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2868 9035608 32.47 µM 1.03812138299196 0.136461101637792 no 567 0.149606773763686 758 6462614 SGTC_3346 9158254 43.5805 µM 1.03717067617975 0.136660211687716 no 568 0.149828160818553 766 17639500 SGTC_1684 st024538 14.6195 µM 1.03701876960364 0.136692044441255 no 569 0.149863554893643 773 6732859 SGTC_1073 triclabendazole 3.09 µM 1.03628559386731 0.136845756223622 no 570 0.150034462486552 817 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3221 9128209 49.47 µM 1.03616076113901 0.136871939424638 no 571 0.150063574673956 732 16460723 SGTC_835 0312-0010 67.2 µM 1.03446627428375 0.137227690450166 no 572 0.150459117739103 726 1626196 SGTC_2505 galangin 7.89 µM 1.03438049338882 0.137245716600621 no 573 0.150479159976371 686 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3008 9078912 71.4286 µM 1.03255849647082 0.137628976303894 no 574 0.150905279664137 738 16648731 SGTC_1344 1488-0097 29.1 µM 1.03231431253034 0.137680396206711 no 575 0.150962449178922 752 747966 SGTC_364 0083-0097 67.7 µM 1.02655532585276 0.138896916997068 no 576 0.152314949624332 770 5207356 SGTC_812 4251-0442 148 µM 1.02399262554749 0.13944060459504 no 577 0.152919379044873 754 5723007 SGTC_906 1165-0455 526 µM 1.02371477403149 0.139499638824769 no 578 0.152985007549515 747 3252859 SGTC_2411 st077133 39.94 µM 1.02203797563787 0.139856263677945 no 579 0.153381463511979 832 1403142 YNL221C POP1 SGTC_1500 4488-1866 171 µM 1.02097799858196 0.140082021134668 no 580 0.153632431332664 831 2900003 SGTC_2738 aclarubicin 5.55 µM 1.01754177762026 0.140815580592473 no 581 0.154447884273952 697 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2627 acetyl isogambogic acid 100 µM 1.01526111181622 0.141303890299701 no 582 0.154990688234356 728 6857789 A caspase activator and apoptosis inducer. SGTC_1701 st028638 40.4 µM 1.01264678784096 0.141865049481446 no 583 0.155614451549416 815 3490878 SGTC_509 pifithrin 175 µM 1.01053363475765 0.142319734781524 no 584 0.156119846678242 831 4817 A p53 inhibitor. SGTC_2775 cyproheptadine 69.59 µM 1.0080120912644 0.142863581966672 no 585 0.156724328807066 798 2913 A selective serotonin reuptake inhibitor. SGTC_1712 st032288 53.4 µM 1.00792819934136 0.142881699910232 no 586 0.156744466410802 900 2883011 SGTC_817 1391-0715 46 µM 1.00668705891486 0.143149927560629 no 587 0.157042591473696 759 1353946 SGTC_2009 4012297 12.05 µM 1.00645321265735 0.143200503034799 no 588 0.15709880366317 743 45595307 SGTC_166 k072-0058 166.424 µM 1.0061815936829 0.143259263013152 no 589 0.157164112304734 801 5846229 SGTC_121 0557-0495 61.343 µM 1.00561415231175 0.143382071491757 no 590 0.157300606711099 992 3104427 SGTC_3003 9075612 71.4286 µM 1.00356601862002 0.14382592995488 no 591 0.157793920328068 771 6501993 SGTC_351 caspofungin 25 nM 1.00321399271847 0.143902312017607 no 592 0.157878811531067 918 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2288 7946289 167.31 µM 1.00183232699237 0.144202368239978 no 593 0.158212290640272 865 1246052 SGTC_788 1182-0090 188 µM 1.00159726224226 0.144253459185785 no 594 0.158269071892821 915 5715185 SGTC_361 000s-0510 1.45 µM 1.00072411804075 0.144443342508835 no 595 0.158480102002797 784 660 SGTC_886 0866-0150 153 µM 1.00007182865525 0.144585306235533 no 596 0.158637874123912 854 271463 SGTC_218 alverine citrate 93.75 µM 0.994874600935899 0.145719784204023 no 597 0.159898628693572 772 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3039 9090270 49.47 µM 0.98807581779737 0.147212869501228 no 598 0.161557758969083 773 17173750 SGTC_1433 4060-0023 7.6 µM 0.988048455651956 0.147218899165692 no 599 0.161564458842128 830 3840627 SGTC_2006 4011487 200 µM 0.987411996226084 0.14735919938142 no 600 0.161720352896369 851 45595294 SGTC_2437 5741531 144.16 µM 0.985264908560753 0.147833161171815 no 601 0.162246982424595 849 2262990 SGTC_1138 3761-0006 1.03 µM 0.984793273200675 0.147937409537277 no 602 0.162362812755574 828 12061087 SGTC_2222 6885208 172.143 µM 0.983100265130085 0.1483120304683 no 603 0.162779046916971 795 609514 SGTC_904 1141-0088 396 µM 0.981759634398549 0.148609128812373 no 604 0.163109139324629 785 1378119 SGTC_2515 chrysin 20.77 µM 0.980868901018851 0.148806744867847 no 605 0.163328697616772 841 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1671 st016596 74.5 µM 0.980047923978139 0.148989040401408 no 606 0.163531231512818 870 2829167 SGTC_3254 9136651 49.47 µM 0.978531132474427 0.149326231785857 no 607 0.163905850697639 848 16454030 SGTC_727 3032-0951 202 µM 0.978064013568426 0.149430177511855 no 608 0.164021332416327 791 3652836 SGTC_900 1112-0045 141 µM 0.972379512940257 0.15069899186603 no 609 0.165430890078257 714 56211 YIL048W NEO1 SGTC_1198 1612-1005 86.7 µM 0.97065958031686 0.151084300607 no 610 0.165858912996623 854 6998509 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.968340247127352 0.151604927475389 no 611 0.166437235349417 779 77254 SGTC_765 1319-0117 244 µM 0.964541384111125 0.152460241723632 no 612 0.167387285332283 780 3487746 YGL099W LSG1 SGTC_717 1532-0246 73.2 µM 0.964144353035142 0.152549817766959 no 613 0.167486779341842 822 9561992 SGTC_2246 7293507 91.5585 µM 0.963699561879774 0.152650210651652 no 614 0.167598287031537 874 887656 SGTC_3217 9129673 49.47 µM 0.962848516961165 0.152842420358202 no 615 0.167811774457813 793 17248312 SGTC_123 0083-0120 66.675 µM 0.962170123618737 0.152995751369035 no 616 0.167982077021305 813 16001701 SGTC_655 k060-0012 42 µM 0.962143616721424 0.15300174454872 no 617 0.167988733519305 814 5994525 SGTC_463 ikarugamyin 104 µM 0.959390166520778 0.153625144330301 no 618 0.168681113531304 833 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1019 4262-0212 3.4 µM 0.954350235252711 0.154770569696715 no 619 0.169953193754524 930 4677213 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.952172059113611 0.155267345611804 no 620 0.170504864401155 1061 16725076 SGTC_2173 5763948 167 µM 0.949794983421565 0.155810684160721 no 621 0.171108217699239 861 2867177 SGTC_114 0364-0001 490.298 µM 0.943383815499309 0.157282355625203 no 622 0.172742309212676 853 4003655 SGTC_223 busulfan 5 mM 0.942460705001602 0.157495004099839 no 623 0.172978410102182 777 2478 A DNA alkylator. SGTC_2996 9066192 71.4286 µM 0.941151526965044 0.157796911245249 no 624 0.173313606574664 837 6472854 SGTC_838 0109-0203 71.4 µM 0.938742601047701 0.158353421742716 no 625 0.173931457647994 873 759422 SGTC_1254 0550-0035 264 µM 0.938478846171241 0.158414432557712 no 626 0.173999191534557 914 15121435 SGTC_1473 k844-0725 134 µM 0.937617224799111 0.158613847118136 no 627 0.174220578099321 955 54682906 SGTC_1739 st037196 92.5 µM 0.93504477497372 0.159210196550987 no 628 0.174882612504016 926 612214 SGTC_3169 9102970 49.47 µM 0.934722836014723 0.15928493221345 no 629 0.174965577564456 897 17027839 SGTC_1834 st055981 52.8 µM 0.931830592419235 0.159957374539303 no 630 0.175712040914252 896 471719 YDL150W RPC53 SGTC_3241 9133421 49.47 µM 0.931520450550716 0.160029592119072 no 631 0.175792205485382 892 17018221 SGTC_2869 9037858 32.47 µM 0.930305679563796 0.160312660906018 no 632 0.17610641900108 888 27187042 SGTC_315 k915-0449 187 µM 0.929000790360395 0.160617093577135 no 633 0.176444338366464 963 20970215 YNL149C PGA2 SGTC_665 3914-0008 307 µM 0.928024792260889 0.160845042116648 no 634 0.176697354713314 850 1069549 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.924586459873131 0.161649761148885 no 635 0.177590529420292 922 6708739 YPR165W RHO1 SGTC_726 3448-4391 34.2 µM 0.922915789623107 0.162041716226141 no 636 0.178025545742069 921 1356692 SGTC_2051 5263410 176 µM 0.920340868120618 0.162647028399626 no 637 0.178697329409389 913 227584 SGTC_1369 1866-0067 208 µM 0.919735318948184 0.162789594178375 no 638 0.178855545567444 941 3531355 SGTC_3061 glucosamine 200 µM 0.919633938894511 0.162813470247894 no 639 0.178882042472103 875 91431 and experimental redox chemotherapeutic SGTC_896 0964-0007 44.5 µM 0.918570121852022 0.163064147675276 no 640 0.179160232905369 923 6756758 SGTC_1017 4239-0030 168 µM 0.916167895253105 0.163631129746424 no 641 0.179789420726932 871 1149593 SGTC_1937 st074714 47.2 µM 0.907772322369572 0.165622723375796 no 642 0.181999262157407 902 17250970 SGTC_3188 9110789 49.47 µM 0.90230669627627 0.16692766532136 no 643 0.183446984704038 894 849217 SGTC_3014 9081533 49.47 µM 0.901148124667807 0.167205128879099 no 644 0.183754784158268 919 21367265 SGTC_2760 etidronate 98.04 µM 0.899202503540928 0.167671749495431 no 645 0.184272403540753 869 3305 A chelator and antioxidant. SGTC_2336 9001819 198.65 µM 0.891654396805644 0.169489949887797 no 646 0.18628910192273 942 2989602 SGTC_1460 k062-0059 9.15 µM 0.891375168886832 0.169557452542094 no 647 0.186363967224598 891 1373085 SGTC_2150 5556613 200 µM 0.89011928572179 0.169861272384549 no 648 0.186700919216514 953 743190 SGTC_2248 tofa 1.1 µM 0.889439818452045 0.170025792680562 no 649 0.18688337661292 890 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.889210897073644 0.170081244707119 no 650 0.186944873729523 872 6708760 SGTC_427 1354-0053 47.3 µM 0.888034853030592 0.1703663026132 no 651 0.187261001897738 901 6813657 SGTC_2928 9011484 9.79 µM 0.886829534583591 0.170658773604613 no 652 0.187585341975164 863 2994751 SGTC_1677 st019204 53.9 µM 0.886320859004871 0.170782300319301 no 653 0.187722325973446 860 3945625 SGTC_1385 3091-4834 14.1 µM 0.884116672842253 0.171318225597222 no 654 0.188316616869642 881 4072814 SGTC_628 1636-0253 16 µM 0.88316574631561 0.17154976524451 no 655 0.188573362894312 932 4456143 SGTC_269 exalamide 29 µM 0.883106744659719 0.171564138052783 no 656 0.188589300192533 908 3316 A derivative of salicylamide. SGTC_1197 1601-0112 267 µM 0.881310254601831 0.172002131527252 no 657 0.189074958638596 934 7350313 SGTC_2557 derrustone 83.84 µM 0.879921561921087 0.172341190638579 no 658 0.189450901559562 991 629853 An antioxidant. SGTC_190 3970-0790 3.722 µM 0.879618037990425 0.172415354890711 no 659 0.189533131910919 911 2832352 SGTC_844 0330-0132 15.3 µM 0.879364507905114 0.172477319048085 no 660 0.189601834817889 1009 2828079 SGTC_174 3553-0389 74.3 µM 0.879036958888367 0.172557394867443 no 661 0.18969061844151 876 738071 SGTC_2974 9094440 9.66 µM 0.876666844581178 0.173137522283144 no 662 0.19033381019471 950 25236134 SGTC_2658 polymyxin b sulfate 77.05 µM 0.873157087111308 0.173998876408462 no 663 0.191288730693427 947 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_31 0508-1974 57.237 µM 0.86918785320742 0.174976270708437 no 664 0.19237219508472 924 6810525 SGTC_2733 amorolfine 100 µM 0.867189772951123 0.175469598707802 no 665 0.192919019439802 932 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_288 1315-0019 35.1 µM 0.865642307396367 0.175852274688778 no 666 0.193343173530325 968 6811474 SGTC_2679 rapamycin 1 nM 0.863786254251991 0.176311958575725 no 667 0.193852660146421 1010 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3115 9123671 49.47 µM 0.856806656420467 0.178047374985017 no 668 0.195775873178524 1029 3286988 SGTC_1642 st009582 77.7 µM 0.855834113838749 0.178290041298086 no 669 0.196044771417874 955 6739311 SGTC_308 4092-1169 104 µM 0.85166847642921 0.179331797010026 no 670 0.197199060841743 990 2268590 YDL196W YDL196W SGTC_972 1319-0219 195 µM 0.851630959988181 0.179341196596752 no 671 0.197209475217228 926 23903702 SGTC_341 1486-1430 230 µM 0.851339969150542 0.179414113648514 no 672 0.197290264110659 978 2054753 YPL210C SRP72 SGTC_1520 flindersine 88 µM 0.848609877900825 0.180099132727594 no 673 0.198049204326827 1008 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1511 0906-3109 28.5 µM 0.848245401855932 0.180190709074559 no 674 0.198150658536861 1073 2882180 SGTC_629 3448-6466 76.7 µM 0.847820840456967 0.180297418998032 no 675 0.198268877439265 992 573744 SGTC_1263 0774-1208 64.8 µM 0.846999368317425 0.180504001653485 no 676 0.198497736770135 1020 906585 SGTC_2119 5528445 120.635 µM 0.846884694270995 0.180532851526041 no 677 0.198529697238946 970 791935 SGTC_144 4161-2749 112.381 µM 0.84353408529409 0.181377079349335 no 678 0.1994649055241 880 797501 YMR168C CEP3 SGTC_300 r073-0011 5.04 µM 0.843129811958455 0.181479107919213 no 679 0.199577923659893 1029 2735780 SGTC_2070 5230947 200 µM 0.843094196623132 0.181488098068711 no 680 0.199587882084166 1061 2835538 SGTC_2606 farnesol 9.78 µM 0.842182903131888 0.181718224826359 no 681 0.199842791080181 955 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_644 1498-1197 63.3 µM 0.840401631477094 0.182168571996581 no 682 0.200341617355594 1016 6741615 SGTC_3083 9117465 49.47 µM 0.839612091047494 0.182368409242808 no 683 0.200562958851046 1027 16420915 SGTC_92 0063-0024 660.874 µM 0.8368616746717 0.183065624586466 no 684 0.201335162589988 1075 3594437 SGTC_3088 9117578 49.47 µM 0.835850014720893 0.183322492565309 no 685 0.201619642797251 1021 678341 SGTC_2696 st077691 74.316 µM 0.834961188035812 0.183548357631839 no 686 0.201869780720577 910 757133 SGTC_2066 5222451 176 µM 0.8336459338442 0.183882902792941 no 687 0.202240266646213 1061 2281147 SGTC_441 propafenone 146 µM 0.8324634292169 0.184184006043446 no 688 0.202573706143432 1011 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1447 4239-0816 81.9 µM 0.827982709666765 0.185327721666172 no 689 0.203840145975069 935 1341554 SGTC_2464 5717415 7.67 µM 0.826665054059141 0.185664894021865 no 690 0.204213466894265 986 5285744 SGTC_2657 nystatin 74.44 µM 0.81744412002782 0.188035058393609 no 691 0.206837335467632 1048 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_672 1441-0018 53.7 µM 0.816340797929164 0.188319903986287 no 692 0.207152623245506 977 251141 SGTC_2700 st077718 96.8 µM 0.816220529112383 0.188350969969609 no 693 0.207187008704902 956 904970 SGTC_271 rotenone 740 µM 0.815787010448856 0.188462976048188 no 694 0.207310981882987 1076 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2294 7971431 200 µM 0.815650743435638 0.1884981911676 no 695 0.20734995917096 935 5741572 SGTC_1497 4476-2978 41.3 µM 0.811928570376722 0.189461671041169 no 696 0.208416309725754 1056 1528379 SGTC_228 caffeine 993.056 µM 0.811626234457138 0.189540063172919 no 697 0.208503066534755 985 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1415 3966-0071 78.1 µM 0.810992713683642 0.189704392335352 no 698 0.208684927545949 1017 2893185 SGTC_1801 st050089 28.441 µM 0.809589453838746 0.190068696263618 no 699 0.209088085684362 1069 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3338 9144300 39.5675 µM 0.809194325519846 0.190171354079466 no 700 0.209201689196115 1026 4901274 SGTC_1299 1079-1439 3.74 µM 0.807589137006683 0.190588746404763 no 701 0.209663571135681 1020 323161 SGTC_537 1334-0398 209 µM 0.807099306308933 0.190716227509762 no 702 0.209804635875661 1048 5846986 SGTC_52 0329-0193 875 nM 0.807025545559756 0.19073542867862 no 703 0.209825882824971 989 3739292 SGTC_1502 4534-4282 27.7 µM 0.80644775297596 0.190885878888713 no 704 0.209992361030646 988 3278949 SGTC_729 4092-0585 94.1 µM 0.805663345309161 0.191090245645017 no 705 0.210218494987254 1008 2169061 SGTC_1603 st002045 67.8 µM 0.803933749944514 0.191541342059953 no 706 0.210717618626259 1052 5887985 SGTC_2910 7948405 25.97 µM 0.802896813349289 0.191812098406842 no 707 0.21101718902896 1019 2971328 SGTC_2495 cafestol 54.53 µM 0.802417236721722 0.191937400717155 no 708 0.211155822839771 1003 16667697 An anti-infammatory. SGTC_1809 st050081 57.6 µM 0.802086321603664 0.192023890409943 no 709 0.211251513376438 1045 5036894 SGTC_721 1187-1332 279 µM 0.800913496921998 0.192330617969555 no 710 0.211590862951186 928 25730 SGTC_1991 st073000 8.92 µM 0.800434450773235 0.192455988525839 no 711 0.211729563737144 1058 4301969 YIL048W NEO1 SGTC_1417 3966-0327 90.4 µM 0.799738848259766 0.192638122697607 no 712 0.211931059939034 1081 651118 SGTC_3198 9112019 49.47 µM 0.796588890799479 0.193464214541348 no 713 0.212844915713026 1039 45595555 SGTC_1665 st014639 11.4 µM 0.793524673130852 0.194269890913244 no 714 0.213736100009715 1115 981133 YIL048W NEO1 SGTC_670 4204-0025 119 µM 0.792349161045693 0.194579510400305 no 715 0.214078557014715 1076 719039 SGTC_501 nsc-95397 161 µM 0.791918778353937 0.194692944451993 no 716 0.214204018415106 1018 262093 SGTC_3321 9137793 26.8275 µM 0.791086277435609 0.194912477163307 no 717 0.214446823173048 1074 4904192 SGTC_902 1120-0002 2.07 µM 0.786202584899228 0.196203349002951 no 718 0.215874405984988 1084 3280475 SGTC_1111 tnp00062 510.699 nM 0.785805448156472 0.196308548769503 no 719 0.215990737147018 1107 676306 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.78564040750478 0.196352277364158 no 720 0.216039092311183 1088 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2552 juarezic acid 87.02 µM 0.784767742912563 0.196583593660936 no 721 0.216294878019085 1184 1549512 SGTC_2971 9092186 9.93 µM 0.783941615406393 0.196802726477136 no 722 0.216537184760958 982 25236400 SGTC_214 4373-3496 70 µM 0.783134107218261 0.197017063355438 no 723 0.216774182087676 1191 3779166 SGTC_1303 1160-0052 261 µM 0.782265105380306 0.197247880261168 no 724 0.217029394798629 1105 3562476 SGTC_2915 7971052 15.16 µM 0.781245237184164 0.197518977566427 no 725 0.217329136034242 939 5741558 SGTC_2913 7966556 36.57 µM 0.78111007749352 0.197554922075105 no 726 0.217368877661081 1018 2976516 SGTC_2532 xanthone 78.9 µM 0.776593908250633 0.198758229169311 no 727 0.218699198361032 978 7020 An insecticide. SGTC_830 4076-0286 57.8 µM 0.776038277257652 0.198906578499536 no 728 0.218863192799583 1145 6866659 SGTC_2360 9040895 200 µM 0.771407098655334 0.200145662988227 no 729 0.220232834403496 1026 4914414 SGTC_2731 amoxapine 43.43 µM 0.769159652790759 0.200748641568444 no 730 0.220899269543697 1091 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1919 st067113 52.3 µM 0.768936768591513 0.200808499664873 no 731 0.220965424263727 1042 1268243 SGTC_3017 9080681 49.47 µM 0.766829120434514 0.201375062023789 no 732 0.221591560057096 1061 16451914 SGTC_552 k242-0005 476 µM 0.766040991193369 0.20158716696716 no 733 0.22182595610492 1080 4088318 SGTC_2013 4024628 200 µM 0.765137796998822 0.201830403222651 no 734 0.222094747468265 1065 5230760 SGTC_2822 7994718 71.43 µM 0.763592235665314 0.202247040678781 no 735 0.222555138838367 1016 1018011 SGTC_2416 tofa 880 nM 0.762000271909092 0.202676724288122 no 736 0.223029920937539 999 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1014 4130-3005 69.3 µM 0.760468513988035 0.203090672421701 no 737 0.223487291466574 1123 743608 SGTC_1232 0279-0259 161 µM 0.760247445424703 0.203150456492543 no 738 0.223553344782436 1100 1560000 SGTC_3139 9095020 49.47 µM 0.759899076688519 0.203244687955994 no 739 0.223657456787263 929 25236292 SGTC_2072 5231554 129 µM 0.759394214771578 0.203381296089216 no 740 0.223808386599512 1178 789545 SGTC_2238 6671620 73.2395 µM 0.757140794994074 0.203991705653888 no 741 0.224482757876166 1114 729941 SGTC_797 k781-0471 270 µM 0.754988528210311 0.204575732693702 no 742 0.225127932736665 1120 23738129 SGTC_1355 1499-0035 1.68 µM 0.75492971235533 0.204591706587424 no 743 0.225145578421905 1100 1548538 SGTC_3024 9090631 49.47 µM 0.753755590244592 0.204910743578067 no 744 0.225497997500556 1075 25236383 SGTC_1049 3226-0134 66 µM 0.753618431254162 0.204948032234237 no 745 0.225539186869117 1154 5702385 SGTC_2156 5649887 115 µM 0.753276961806954 0.205040883166359 no 746 0.225641749942309 1162 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_751 0833-0568 350 µM 0.753150490573811 0.205075279035047 no 747 0.225679743282422 1129 6954252 SGTC_3289 9119912 71.43 µM 0.751687199665923 0.205473493653618 no 748 0.226119594968719 1122 17014829 SGTC_2276 7947513 42.08 µM 0.749714001814461 0.206011198896573 no 749 0.22671348637237 1049 2105100 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.748281567433325 0.206402065958977 no 750 0.227145170108949 1146 16623 A steroid. SGTC_3026 9090633 49.47 µM 0.744799222910471 0.2073541208747 no 751 0.228196552375463 1131 25236842 SGTC_2269 7935389 174.42 µM 0.744792947559614 0.207355838863325 no 752 0.228198449482776 1059 97605 SGTC_2508 celastrol 40.54 µM 0.742716181165064 0.207924852616534 no 753 0.228826765533596 1093 122724 Celastrol is a natural product and antioxidant. SGTC_21 0849-0113 22.993 µM 0.74067243317099 0.208485718736556 no 754 0.22944603891112 1118 1560156 SGTC_861 0443-0273 110 µM 0.739564500821785 0.208790141347843 no 755 0.229782144236704 1124 6149169 SGTC_2324 6149169 200 µM 0.738365330828312 0.209119927995272 no 756 0.230146238132749 1079 2888231 SGTC_1291 0993-0025 5.79 µM 0.737936535708797 0.20923792638554 no 757 0.230276507881514 1139 4353356 SGTC_799 1310-0557 151 µM 0.737832740312754 0.209266495310523 no 758 0.230308047554483 1125 5354492 SGTC_626 0214-0009 33 µM 0.736909165689729 0.209520803574709 no 759 0.230588794886456 1141 3437874 SGTC_2247 cerulenin 830 nM 0.735203947040688 0.209990816617203 no 760 0.231107647782449 1187 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1573 oleylamine 1.06 µM 0.732554797087645 0.210722235091013 no 761 0.231915004791291 1152 5356789 An amine of the fatty acid oleic acid. SGTC_1646 st011709 75.6 µM 0.731256086842349 0.211081348410092 no 762 0.232311373784388 1133 5757843 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.729099656058117 0.211678426259975 no 763 0.232970352498431 1153 229346 A bile salt which induces apoptosis. SGTC_1345 1488-0192 31.4 µM 0.728614561154004 0.21181287659794 no 764 0.233118734445105 1181 658348 SGTC_422 cantharidin 155 µM 0.726619283037501 0.212366418965835 no 765 0.233729606126146 1159 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2243 6634756 200 µM 0.725804097492982 0.212592815777867 no 766 0.233979437327064 1147 885676 SGTC_1180 1193-0155 285 µM 0.725323862057612 0.212726254768996 no 767 0.234126685054918 1138 2921347 SGTC_923 1900-2434 73.3 µM 0.724882183912589 0.212849023327692 no 768 0.234262155798721 1149 5910570 SGTC_1301 naphtanilide LB 4.81 µM 0.723762118213395 0.213160541382248 no 769 0.2346058948423 1201 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1265 0819-1001 68.8 µM 0.723505815603271 0.213231862864719 no 770 0.234684591227552 1153 3106768 SGTC_662 k832-1615 104 µM 0.717033264937759 0.215037591680961 no 771 0.236676785701549 1134 5878478 SGTC_2310 7668677 200 µM 0.716338321379608 0.215231995261971 no 772 0.236891234889635 1178 2197143 SGTC_3171 9103192 49.47 µM 0.715927141992263 0.215347066639326 no 773 0.237018168983206 1216 13018434 SGTC_1102 cgs 12066b 26.1 µM 0.715421946787486 0.215488497849927 no 774 0.237174177614349 1124 6438352 A 5-HT1B full agonist. SGTC_204 PMA1.184 62.41 µM 0.713347069793208 0.216069931853778 no 775 0.237815508750865 1206 2252213 YGL008C PMA1 SGTC_2397 5161689 200 µM 0.713046289659115 0.216154293545551 no 776 0.237908556822534 1193 2259942 SGTC_1478 0453-0656 35.7 µM 0.710736370053528 0.216802806627011 no 777 0.238623808676883 1198 5258496 SGTC_125 0133-0007 11.75 µM 0.710074448885702 0.216988849067475 no 778 0.238828985057377 1253 26541 SGTC_794 k038-0031 316 µM 0.707398295210714 0.217741960419807 no 779 0.239659498024423 1214 6624242 SGTC_318 1488-0629 67.2 µM 0.707313394287793 0.217765877514989 no 780 0.23968587180311 1181 3662576 SGTC_2593 nobiletin 86.24 µM 0.703487403578402 0.218845253782726 no 781 0.240876027030365 1144 72344 An anti-infammatory. SGTC_1513 0337-0559 19 µM 0.703391840573891 0.218872253055886 no 782 0.24090579501809 1129 775073 SGTC_486 niguldipine 82 µM 0.702427181349349 0.219144904076719 no 783 0.241206399522117 1183 1236 A calcium channel blocker. SGTC_1666 st014829 29 µM 0.702380201785828 0.219158187352468 no 784 0.241221044371303 1218 3858230 SGTC_3333 9141820 12.094 µM 0.701698204137118 0.219351071473784 no 785 0.24143369660929 1147 1939433 SGTC_2193 5925765 200 µM 0.700820228540897 0.219599526093922 no 786 0.241707606176363 1193 877370 SGTC_2734 clemastine 41.6 µM 0.700640816616091 0.219650317000273 no 787 0.241763599600145 1150 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2 0422-0095 29 µM 0.698944322415551 0.220130922100722 no 788 0.242293413467482 1091 6790840 SGTC_152 4469-0003 551.229 µM 0.698778531876893 0.220177921746116 no 789 0.242345223457871 1180 697280 SGTC_2234 tolnaftate 200 µM 0.697806697065565 0.220453541067125 no 790 0.242649045153484 1169 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_25 0118-0223 35.662 µM 0.697314447177163 0.220593222074437 no 791 0.242803014352579 1220 5333628 SGTC_1152 3909-8331 15.9 µM 0.696554200841626 0.220809049446889 no 792 0.243040913119684 1185 16001939 SGTC_100 0086-0128 49.5915 µM 0.695588130153688 0.221083482948571 no 793 0.243343400911943 1177 93297 SGTC_2376 9072922 81.32 µM 0.695304318116891 0.221164143039671 no 794 0.243432304359018 1225 17087968 SGTC_3203 9113543 49.47 µM 0.69350467857925 0.221675996790706 no 795 0.243996445381565 1214 17018012 SGTC_2120 5538279 151.968 µM 0.693330399040168 0.221725601327554 no 796 0.244051114997139 1203 2058197 SGTC_671 0560-0003 407 µM 0.692428875257187 0.221982299916519 no 797 0.244334018759438 1140 3238678 SGTC_2059 5238311 157 µM 0.69146768420935 0.222256174885294 no 798 0.244635841057178 1208 703021 SGTC_702 1488-0190 94 µM 0.691266990780538 0.222313383370337 no 799 0.244698885857013 1202 949357 SGTC_2769 toremifene 3.73 µM 0.690602502256936 0.222502858493054 no 800 0.244907687276122 1219 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_824 1304-0008 100 µM 0.689536877770522 0.222806907421673 no 801 0.2452427372284 1206 768245 SGTC_2693 st077581 40.7 µM 0.687800958131912 0.223302714678088 no 802 0.245789066341029 1224 25238761 SGTC_3253 9135987 49.47 µM 0.686973874475354 0.223539164079612 no 803 0.24604959596341 1204 4182430 SGTC_881 0833-0569 170 µM 0.685292942186243 0.224020153090377 no 804 0.246579542289531 1201 5418700 SGTC_1781 st038725 66.3 µM 0.685097383808595 0.224076149139198 no 805 0.246641235519628 1231 4270275 YIL048W NEO1 SGTC_3335 9143315 29.6265 µM 0.684616510961611 0.224213875739692 no 806 0.246792972681563 1201 4899691 SGTC_529 4076-0302 30.3 µM 0.683314648110984 0.224586982886016 no 807 0.247204020046897 1181 5816522 SGTC_1244 0416-0015 52.5 µM 0.682210063145632 0.224903827233788 no 808 0.247553066204067 1224 96201 SGTC_3103 9120822 49.47 µM 0.681174249442554 0.225201174986072 no 809 0.24788061987693 1281 17141819 SGTC_2366 9070441 60.58 µM 0.678673734593132 0.22591990672762 no 810 0.248672305948275 1225 6837235 SGTC_2607 solasodine 47.35 µM 0.678126268625321 0.226077439680527 no 811 0.248845818246405 1241 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2114 5491910 81.25 µM 0.676850747375589 0.226444710767287 no 812 0.249250328177711 1262 2849228 SGTC_2736 butenafine 14.65 µM 0.675976967114897 0.226696499673248 no 813 0.249527634436402 1212 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1359 1582-0056 520 nM 0.675736769884265 0.226765742688849 no 814 0.249603893066621 1254 3661189 SGTC_1788 fluconazole 20 µM 0.675602064494578 0.226804580196398 no 815 0.249646665207682 1208 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3238 9133470 49.47 µM 0.675268787356523 0.226900684930293 no 816 0.249752505295259 1242 3534688 SGTC_1445 4239-0156 97.7 µM 0.674449893615546 0.227136920963855 no 817 0.250012665657802 1281 4008346 SGTC_3284 9108171 64.8615 µM 0.674259364980037 0.227191904904487 no 818 0.250073216712219 1184 8687505 SGTC_606 k015-0008 38.6 µM 0.672260420481093 0.227769224798407 no 819 0.250708961053812 1281 1970475 SGTC_1669 st015249 58.4 µM 0.672250276989838 0.227772156468106 no 820 0.250712189271172 1300 722793 SGTC_2290 7904846 200 µM 0.67149684528085 0.227989972505288 no 821 0.250952034250449 1256 2962154 SGTC_833 3852-0053 558 µM 0.669769828126685 0.228489692534535 no 822 0.251502265076156 1276 3123681 SGTC_2748 diazoxide 86.69 µM 0.668648921883407 0.228814360716999 no 823 0.25185972870769 1188 3019 A potassium channel activatior. SGTC_1356 1502-0781 85.8 µM 0.667806007067284 0.229058679746205 no 824 0.252128715796827 1215 567702 SGTC_1374 2889-5571 141 µM 0.667740067204722 0.229077798598677 no 825 0.252149764610595 1242 2853281 SGTC_2870 9038528 12.99 µM 0.666169381745582 0.229533473595195 no 826 0.252651420551844 1230 6463316 SGTC_2507 purpurin 79.67 µM 0.664174843038867 0.230112844823757 no 827 0.253289206347006 1235 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.662737328323564 0.230530919227133 no 828 0.253749399104219 1257 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1740 st038286 13.222 µM 0.662089159881392 0.230719565725431 no 829 0.253957041304639 1265 716786 SGTC_2467 5474540 200 µM 0.661841228840395 0.230791747730572 no 830 0.254036490133563 1234 5413519 SGTC_2105 5350118 200 µM 0.661110591508241 0.231004536937514 no 831 0.254270696696933 1259 2133313 SGTC_2297 7971671 152.32 µM 0.660786045545848 0.231099092104793 no 832 0.254374766545153 1280 909016 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.660295267270068 0.231242119410332 no 833 0.254532183324061 1315 94937 An inhibitor of serotonin biosynthesis. SGTC_2727 riluzole 51.77 µM 0.660088877702304 0.231302282181946 no 834 0.254598397870138 1247 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3292 9120825 59.784 µM 0.658475320697665 0.231772936542504 no 835 0.255116375110088 1262 24824900 SGTC_3056 9094900 49.47 µM 0.657756515810377 0.23198277458034 no 836 0.255347300143642 1194 25236784 SGTC_2159 5658611 73.75 µM 0.657727035913911 0.231991382794485 no 837 0.255356773259719 1276 793844 SGTC_2689 tacrolimus 100 µM 0.657342016232944 0.232103825972337 no 838 0.255480512950254 1261 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3308 9128332 17.569 µM 0.656617618395856 0.23231546514656 no 839 0.255713408706274 1275 17332805 YDL196W YDL196W SGTC_1819 st053448 58.6 µM 0.65621761956163 0.232432374303896 no 840 0.255842056842366 1220 2857616 SGTC_462 ag-879 158 µM 0.655767151908799 0.232564073337214 no 841 0.255986977257205 1256 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2137 5261020 140 µM 0.65568167924706 0.232589066865601 no 842 0.256014479588931 1240 763655 SGTC_3163 9099914 49.47 µM 0.655532622334744 0.232632656985006 no 843 0.256062444958972 1284 16268368 SGTC_2011 4012611 177 µM 0.653562123779349 0.233209335113304 no 844 0.256696976569851 1263 2049887 SGTC_2890 9046729 58.44 µM 0.653420781009917 0.233250730393156 no 845 0.256742522617769 1195 903329 SGTC_187 1488-2104 32.728 µM 0.653325004057363 0.233278783058124 no 846 0.256773388007276 1295 2852859 SGTC_2536 dehydroabietamide 32.04 µM 0.650813851265257 0.234014956836641 no 847 0.257583328883702 1301 3983547 SGTC_285 1486-1325 46 µM 0.650099453399429 0.23422462579579 no 848 0.257813991145021 1284 22310230 SGTC_1860 st056228 74.6 µM 0.649561212740033 0.234382662964315 no 849 0.257987847169536 1242 688679 SGTC_2567 aureobasidin a 60 nM 0.646866735043385 0.235174696656572 no 850 0.258859098312027 1338 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1699 st031318 29.054 µM 0.646157626151463 0.235383382511633 no 851 0.259088639287225 1326 5340658 SGTC_2591 skatole 100 µM 0.644822277346709 0.235776643770506 no 852 0.25952118179189 1282 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3066 9117245 49.47 µM 0.642218533370408 0.236544489194601 no 853 0.260365650535914 1334 17176980 SGTC_2842 9000675 19.48 µM 0.642043683513867 0.236596101764846 no 854 0.260422410029423 1223 2989072 SGTC_728 3030-5151 22.5 µM 0.641276205204557 0.236822720992494 no 855 0.26067162302328 1303 3125388 SGTC_733 4069-0007 56.1 µM 0.640358221540076 0.237093937783778 no 856 0.260969868737585 1315 5717425 YNL287W SEC21 SGTC_903 1134-0042 114 µM 0.64015740849647 0.237153290416348 no 857 0.261035134708085 1276 701009 SGTC_2750 bromebric acid 70.15 µM 0.639155736572644 0.237449468087407 no 858 0.26136081199818 1324 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2080 5212524 12.4 µM 0.63698888251539 0.238090864852319 no 859 0.262066042615541 1266 260183 SGTC_883 0850-0245 24.6 µM 0.63485575719676 0.238723204112077 no 860 0.262761247238991 1356 6823229 YPR165W RHO1 SGTC_2122 5258151 111.688 µM 0.633664062660408 0.239076867232832 no 861 0.263150041444166 1267 2173356 SGTC_921 1561-0023 372 µM 0.633110976841347 0.239241105591733 no 862 0.263330587294093 1289 24050882 SGTC_2767 sibutramine 71.45 µM 0.631287057674618 0.239783153404761 no 863 0.263926423876001 1365 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2981 9013952 38.96 µM 0.625186732123064 0.241600958630578 no 864 0.265924254430368 1210 2996344 SGTC_952 1185-0122 232 µM 0.624581651796798 0.241781670460987 no 865 0.266122832545677 1243 678600 SGTC_1304 1165-0502 251 µM 0.62445908374416 0.241818285272308 no 866 0.266163066651079 1310 767425 SGTC_2413 inermin 26.06 µM 0.623826481822749 0.242007310569207 no 867 0.266370773083081 1432 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2930 9013230 14.89 µM 0.623316585212401 0.242159729083898 no 868 0.266538250532493 1298 2995857 SGTC_366 0181-0206 4.31 µM 0.622119981746558 0.242517622588141 no 869 0.266931488434501 1346 274874 SGTC_2280 7785178 200 µM 0.619299005694145 0.243362484145046 no 870 0.26785969968462 1329 2954328 SGTC_689 0833-0039 98 µM 0.618955970930011 0.243465328883854 no 871 0.267972682285864 1305 5374726 SGTC_1828 st055811 49 µM 0.618318115462866 0.24365662578053 no 872 0.268182831385673 1279 5877589 SGTC_1151 3909-8316 15.3 µM 0.617485767113016 0.243906374327769 no 873 0.26845718314806 1313 800431 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.616357858223935 0.244245026970799 no 874 0.268829180162742 1317 5106787 A p450 inhibitor. SGTC_2469 5655019 90.81 µM 0.615780989570127 0.244418328686913 no 875 0.269019537931474 1417 2788239 SGTC_1534 6-azauridine 81.6 µM 0.611713766970298 0.245642073722966 no 876 0.270363575875151 1325 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1285 0929-0069 65.5 µM 0.610662417888967 0.245958937779536 no 877 0.270711545591358 1324 1206237 SGTC_516 3992-2719 87.3 µM 0.610420207519869 0.246031968163663 no 878 0.270791742723896 1254 5350887 YDR037W KRS1 SGTC_740 k014-0057 261 µM 0.60997222328005 0.246167073382545 no 879 0.270940103918362 1368 4012779 SGTC_2047 4141938 200 µM 0.609390316836572 0.246342626886292 no 880 0.271132877339821 1335 3807862 SGTC_1762 st045503 25.4615 µM 0.608601312715522 0.246580766171288 no 881 0.271394367078691 1331 4645554 SGTC_1939 st074455 53.6 µM 0.608151516553083 0.246716579992729 no 882 0.271543493593497 1418 1644229 SGTC_2560 caryophyllene 100 µM 0.606694617989136 0.247156758466012 no 883 0.272026797278566 1353 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1579 chlormadinone acetate 49.4 µM 0.604878534313539 0.247706046520626 no 884 0.272629853438646 1354 45114258 A steroidal progestin. SGTC_199 4063-0024 41.6 µM 0.604533719571346 0.247810411900499 no 885 0.272744428940134 1367 306215 SGTC_2624 nerol 100 µM 0.604361189502876 0.247862640537518 no 886 0.272801766427215 1316 637566 A natural product oil. SGTC_1120 ficusin 1.78878 µM 0.603349446485738 0.248169035567274 no 887 0.273138122621042 1439 6199 A DNA cross-linker. SGTC_3298 9116858 71.43 µM 0.602542248915013 0.248413631096632 no 888 0.273406624540143 1396 2506942 SGTC_2875 9039966 71.43 µM 0.601678779174713 0.248675420282429 no 889 0.273693989132253 1441 6463691 SGTC_574 1315-0397 40 µM 0.59889670841797 0.249519894714172 no 890 0.274620883287128 1338 6794277 SGTC_3035 9091303 49.47 µM 0.598853954405466 0.249532884216616 no 891 0.274635139583876 1346 25237002 SGTC_3312 9133330 71.43 µM 0.598105188217907 0.249760432214402 no 892 0.274884874325685 1389 17617324 SGTC_2782 7736369 71.43 µM 0.597679310040711 0.249889904566832 no 893 0.275026966679831 1375 2950836 YOL077C BRX1 SGTC_1082 camptothecin 424.86 nM 0.597639614824905 0.249901974229272 no 894 0.275040212654689 1258 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_518 1021-0119 62.6 µM 0.597349691216047 0.249990137310138 no 895 0.275136967363915 1289 1097762 SGTC_1404 3909-7820 48.3 µM 0.597286940373512 0.250009221431934 no 896 0.275157911084882 1327 23741373 SGTC_352 k048-0007 5.11 µM 0.595836024040867 0.250450697360421 no 897 0.275642387716704 1313 6811911 SGTC_2774 tamoxifen 10.92 µM 0.594651613239828 0.250811388672614 no 898 0.276038185939438 1367 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.593112872903765 0.251280395181026 no 899 0.27655280798582 1342 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1008 4106-0037 6 µM 0.59009579148844 0.252201342848462 no 900 0.27756321508957 1339 2905394 SGTC_72 0744-0168 198.391 µM 0.589408240308769 0.252411462865037 no 901 0.277793725033856 1374 677577 SGTC_1031 k035-0009 16 µM 0.588557164223405 0.252671684870288 no 902 0.278079188103334 1389 5180959 SGTC_504 lovastatin 124 µM 0.588333390033898 0.252740128724163 no 903 0.278154268913637 1311 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2478 5763493 32.33 µM 0.5867160814849 0.25323509085396 no 904 0.278697202712404 1340 1365576 YLR208W SEC13 SGTC_219 mitoxanthrone 164.414 µM 0.586084289684487 0.253428583170321 no 905 0.278909436571832 1384 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_768 0384-0033 77.3 µM 0.5853281869512 0.253660248999206 no 906 0.27916353273992 1333 3965305 YMR134W ERG29 SGTC_646 4092-0839 27.3 µM 0.583655540560064 0.254173133799334 no 907 0.279726042416733 1436 877796 SGTC_3101 9120531 49.47 µM 0.583611741970587 0.254186571096241 no 908 0.279740779234409 1413 24824904 SGTC_2979 9012552 45.46 µM 0.58270776608455 0.254463991790455 no 909 0.280045022160191 1408 17100905 SGTC_2196 6573537 42.6665 µM 0.580441564001112 0.255160162177556 no 910 0.280808441442135 1433 2903087 SGTC_79 0052-0007 94.094 µM 0.579451254899812 0.255464694551533 no 911 0.281142364178741 1425 2801472 SGTC_2830 7992007 71.43 µM 0.576789905217532 0.256284032673239 no 912 0.28204069485799 1383 1952075 SGTC_1982 st072467 71.9 µM 0.576706988167417 0.256309581969776 no 913 0.282068705451915 1358 3163533 SGTC_2776 terbinafine 19.92 µM 0.576616056712339 0.256337602277502 no 914 0.282099424969134 1363 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2989 9073649 71.4286 µM 0.574737829861632 0.256916730205743 no 915 0.282734309310835 1367 21367202 SGTC_2075 5212009 200 µM 0.573630790216276 0.257258390742267 no 916 0.283108835738007 1378 780898 SGTC_116 0155-0182 31.788 µM 0.56995936500343 0.258393173944259 no 917 0.284352629521215 1376 771486 SGTC_2214 7179297 48.276 µM 0.568824200623796 0.258744560616066 no 918 0.2847377247598 1422 769744 SGTC_969 1313-0238 134 µM 0.568547454949692 0.258830263877884 no 919 0.284831646193368 1409 5212874 SGTC_2342 7990637 118.86 µM 0.567278739813988 0.25922335055726 no 920 0.285262409489114 1421 2033102 YER133W GLC7 SGTC_2519 cryptotanshinone 88.04 µM 0.564696509467096 0.26002435637994 no 921 0.286140104409664 1404 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2470 5664817 21.68 µM 0.564484362358692 0.260090220935483 no 922 0.286212269775046 1418 2859561 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.563250879247275 0.26047334635295 no 923 0.286632030699176 1354 5355888 SGTC_1161 k007-0610 110 µM 0.562743611122996 0.260630990414452 no 924 0.286804741447289 1447 5843850 SGTC_2164 5685496 200 µM 0.562190059245342 0.260803074128262 no 925 0.286993266793791 1394 759046 SGTC_1808 st050063 61.5 µM 0.556450750786755 0.262590702265108 no 926 0.2889513765375 1438 4011993 SGTC_1989 st071868 50.2 µM 0.552543291173364 0.263811340473332 no 927 0.290288091389235 1445 16414057 SGTC_1142 3253-1408 9.78 µM 0.550335006145735 0.264502456561553 no 928 0.29104480907505 1409 256655 SGTC_1373 2887-0003 58.5 µM 0.550106648951927 0.264573976913045 no 929 0.291123113258364 1406 776948 SGTC_2187 6125751 200 µM 0.549711989194046 0.264697605601234 no 930 0.291258466146474 1416 874498 SGTC_296 1222-0039 74.9 µM 0.549346984554875 0.264811970853531 no 931 0.291383674627727 1356 5984176 SGTC_2170 morpholine 200 µM 0.548475457006535 0.265085144197753 no 932 0.291682738495524 1493 121171 Reacts with secondary amines. SGTC_510 ag-490 170 µM 0.54561606135028 0.265982403019289 no 933 0.292664940769941 1510 5328779 SGTC_2382 9035899 200 µM 0.545344450408402 0.266067712620687 no 934 0.292758318958566 1425 6462679 SGTC_967 1306-0166 352 µM 0.544033937641907 0.266479522938602 no 935 0.293209059564923 1459 4437607 SGTC_1130 3454-2858 15.9 µM 0.543444071393173 0.26666498532211 no 936 0.29341204438904 1403 715628 YIL048W NEO1 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.543229100439347 0.266732591484292 no 937 0.293486036395249 1526 1273210 SGTC_533 1222-0222 6.71 µM 0.543113407783546 0.266768979224444 no 938 0.293525860848094 1515 3982874 SGTC_169 k015-0017 16.025 µM 0.542597512729722 0.26693126945035 no 939 0.293703475938303 1492 1840002 SGTC_1802 st050112 57.9 µM 0.5422310616821 0.267046577878882 no 940 0.293829669859202 1398 4662563 SGTC_1245 0418-0076 17.2 µM 0.541820817835601 0.267175696095947 no 941 0.293970974358679 1455 6790114 SGTC_14 0354-0009 295 µM 0.538737270098109 0.268147204873757 no 942 0.295034076582897 1464 1713507 SGTC_1811 st050069 61.5 µM 0.538414510494072 0.268248996855931 no 943 0.295145455410843 1425 3877702 SGTC_1902 st060212 70.5 µM 0.537659209822671 0.268487279672021 no 944 0.29540617241106 1429 688944 SGTC_3275 9138069 49.47 µM 0.536721784862273 0.268783167115406 no 945 0.295729902897589 1445 17617007 SGTC_2670 beta-carotene 100 µM 0.536104474371348 0.268978103497834 no 946 0.295943173982748 1379 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2877 9040724 71.43 µM 0.535763033521881 0.269085955312342 no 947 0.296061166761435 1511 6463895 SGTC_3184 9108758 49.47 µM 0.534629752994839 0.269444083078792 no 948 0.296452952719765 1435 902885 SGTC_1881 5652484 16 µM 0.53413273273626 0.269601221692179 no 949 0.296624852320559 1478 2255129 SGTC_2773 thioridazine 9.09 µM 0.53343856504255 0.269820767531397 no 950 0.296865013783133 1440 5452 An antipsychotic. SGTC_947 3447-0010 211 µM 0.530512881395706 0.27074706206884 no 951 0.29787819014107 1425 748350 SGTC_1231 0242-0792 125 µM 0.530054805446438 0.270892236147675 no 952 0.298036966391585 1406 3707635 SGTC_141 0443-0274 32.331 µM 0.528704315963099 0.271320461142976 no 953 0.298505291363051 1494 1627241 SGTC_3023 9089636 49.47 µM 0.527743831339859 0.271625225149294 no 954 0.298838573395578 1511 17249241 SGTC_1087 pterostilbene 9.05 µM 0.527303563242242 0.271764980190148 no 955 0.298991400109302 1543 5281727 Similar to reservatol, lowers cholesterol. SGTC_1718 roemerine 11.9335 µM 0.527244491737173 0.271783734079621 no 956 0.299011907824717 1395 235224 An aporphine alkaloid with mutagenic activity. SGTC_128 0906-2981 13.371 µM 0.526763744120766 0.271936384704286 no 957 0.299178831590532 1491 6740226 SGTC_2228 7354201 200 µM 0.526353564573332 0.272066661729289 no 958 0.29932128634516 1508 753451 SGTC_3195 9113082 49.47 µM 0.525494892368217 0.272339484836228 no 959 0.299619601515471 1444 17018038 SGTC_1256 0570-0116 285 µM 0.524886307475065 0.272532930787037 no 960 0.299831114266952 1421 410638 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.524070079214976 0.272792485714536 no 961 0.300114899237486 1422 688803 SGTC_1735 st034310 56.75 µM 0.523483521161937 0.272979082804728 no 962 0.300318907813764 1542 871153 SGTC_2891 9063876 19.48 µM 0.522208872006617 0.273384794949044 no 963 0.300762454734396 1451 6472478 SGTC_2365 9042475 200 µM 0.521938498189513 0.273470891461492 no 964 0.300856576235022 1428 6464479 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.520434600425253 0.273950030118904 no 965 0.301380349670027 1527 688761 SGTC_805 3852-0218 479 µM 0.520301246757197 0.273992536336391 no 966 0.301426813531394 1409 6615355 SGTC_1034 k072-0165 12.7 µM 0.519875969588668 0.274128114360165 no 967 0.301575012610462 1559 5835461 SGTC_3158 9100007 49.47 µM 0.51914202443581 0.274362173417706 no 968 0.301830852279029 1427 19297233 SGTC_1196 1588-0294 184 µM 0.518753672483439 0.27448606084266 no 969 0.301966264017258 1418 6144269 SGTC_2201 6605497 169.863 µM 0.517667323082394 0.27483276166262 no 970 0.302345200481935 1497 670741 SGTC_1365 1672-3266 55.4 µM 0.517051658520371 0.275029342488617 no 971 0.30256004902025 1491 6415873 SGTC_551 k048-0028 34.9 µM 0.514381979196592 0.275882567847489 no 972 0.303492477984541 1518 6836383 SGTC_829 1635-0120 117 µM 0.513984314824378 0.276009771950474 no 973 0.303631478504139 1560 285054 SGTC_2964 9083345 53.42 µM 0.513478775394256 0.276171524486733 no 974 0.303808226938423 1408 17741579 SGTC_476 mead acid 10 µM 0.513357066191124 0.276210473544991 no 975 0.303850786183382 1483 5312531 An omega 9 fatty acid. SGTC_2309 7664088 163.95 µM 0.512655403128043 0.276435070463139 no 976 0.30409619539653 1491 704922 SGTC_3097 9117246 49.47 µM 0.510307951137165 0.277187122082195 no 977 0.304917866587414 1454 16423892 SGTC_2270 7924575 90.91 µM 0.510007792874037 0.277283355711615 no 978 0.305023001122458 1589 1262135 SGTC_1405 3909-7894 12 µM 0.509950574181369 0.277301702429633 no 979 0.305043044578585 1536 7104060 SGTC_3351 9150312 21.596 µM 0.509819902224475 0.2773436035776 no 980 0.305088820582642 1460 4904905 SGTC_1675 st018485 24.5 µM 0.509418941733688 0.277472194516375 no 981 0.305229301039211 1486 3323024 SGTC_1521 st012942 49.4 µM 0.509372450415744 0.277487106504565 no 982 0.305245591587229 1633 24207259 SGTC_2892 9047358 58.44 µM 0.508461382726609 0.277779408487485 no 983 0.305564907336762 1436 6466771 SGTC_1107 amlodipine 47 µM 0.508193660196995 0.277865331695486 no 984 0.305658768259091 1410 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_934 2950-0684 338 µM 0.507062992320486 0.278228352714172 no 985 0.3060553102529 1583 1121253 SGTC_3256 9138902 49.47 µM 0.506090185885442 0.278540874473987 no 986 0.30639666991306 1523 17228773 SGTC_3230 9131665 49.47 µM 0.504204084898246 0.279147286039954 no 987 0.307058985095911 1460 15943720 SGTC_319 1348-1596 45.5 µM 0.503713525369349 0.279305113866934 no 988 0.307231351222259 1588 5380505 SGTC_2612 dictamnine 15.46 µM 0.503443897822217 0.279391879659135 no 989 0.307326107420324 1488 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_588 3970-1144 52.9 µM 0.500697567620297 0.28027639021027 no 990 0.308291992197539 1493 1888707 SGTC_312 4092-0653 6.84 µM 0.497412190942551 0.281336289990033 no 991 0.309449205227712 1534 1148278 SGTC_1736 st036774 51 µM 0.4963226613088 0.281688211303772 no 992 0.309833390210801 1658 1272247 SGTC_1560 lithocholic acid 53.1 µM 0.495830942637598 0.281847107376729 no 993 0.310006845888868 1485 9903 A bile acid which acts as a detergent. SGTC_2257 7960413 200 µM 0.495489524709215 0.28195746002519 no 994 0.31012730727479 1560 2974689 YIL048W NEO1 SGTC_994 3910-0338 138 µM 0.49537650414745 0.281993994965457 no 995 0.310167188445288 1577 3479481 SGTC_698 k064-0052 127 µM 0.494738685304639 0.282200218527705 no 996 0.31039229519673 1554 5088751 SGTC_2296 7971656 126.45 µM 0.493917865383904 0.28246571790802 no 997 0.310682093439914 1479 666570 SGTC_1109 tnp00067 928.257 nM 0.491955024209853 0.283101097898849 no 998 0.311375569318607 1474 676295 SGTC_2102 5377816 72.7585 µM 0.490151599260117 0.283685478087683 no 999 0.31201331371616 1580 1379702 SGTC_730 1436-0052 41.2 µM 0.49006420682355 0.283713811324655 no 1000 0.312044232606316 1503 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_410 α-linolenic acid 100 µM 0.486625485605046 0.284829743085463 no 1001 0.313261879731421 1548 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_864 0469-0573 172 µM 0.483693769079964 0.285782792782293 no 1002 0.314301607956738 1468 689425 SGTC_657 3534-0529 86.7 µM 0.482036171080879 0.286322319209817 no 1003 0.314890125616468 1594 1049549 SGTC_2543 pimpinellin 60.67 µM 0.480603155124219 0.286789136497898 no 1004 0.315399286301755 1450 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2642 cholecalciferol 100 µM 0.480304669765363 0.28688641605209 no 1005 0.315505384425913 1538 9821465 A vitamin D precursor, similar to steriods. SGTC_534 k292-0788 63.4 µM 0.479156895660156 0.287260633430687 no 1006 0.315913508159754 1581 4146317 SGTC_1466 k213-0079 57.5 µM 0.478385187742043 0.287512368938215 no 1007 0.316188037111576 1506 3657981 SGTC_782 0083-0095 30.5 µM 0.476287230919941 0.288197261105928 no 1008 0.316934880571665 1511 3591729 An indicator and reagent. SGTC_1623 st003709 20.3 µM 0.475936747879341 0.288311753645097 no 1009 0.317059720515638 1485 16192618 SGTC_2799 7812892 81.82 µM 0.47519680175746 0.288553542776079 no 1010 0.3173233532418 1610 20205235 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.475130681761385 0.288575153182656 no 1011 0.317346915410144 1493 2346 DNA damaging agent; causes G2/M arrest. SGTC_2100 5377183 190 µM 0.473891180529283 0.288980408078301 no 1012 0.317788754360872 1615 2844202 SGTC_716 1683-5115 658 µM 0.472633886573194 0.289391753644302 no 1013 0.318237201018505 1526 723597 SGTC_966 1300-0360 30.2 µM 0.471616977274216 0.289724654281921 no 1014 0.318600103237482 1529 70588 SGTC_656 4090-1979 187 µM 0.468874387184452 0.290623377370452 no 1015 0.319579712482892 1622 22330961 SGTC_756 0508-1999 28.3 µM 0.468390103528199 0.290782208322031 no 1016 0.319752821953102 1450 6753853 SGTC_803 4488-1585 147 µM 0.468012546821658 0.290906064086968 no 1017 0.319887808618012 1583 747204 SGTC_2902 5787006 60.46 µM 0.467517555128103 0.291068481208175 no 1018 0.320064817580904 1502 591003 SGTC_2601 securinine 100 µM 0.465726234760757 0.291656604571936 no 1019 0.320705735647859 1497 442872 A GABA receptor antagonist. SGTC_3121 9125696 49.47 µM 0.464878753227672 0.291935041213561 no 1020 0.321009143299741 1586 1235365 SGTC_1729 st035615 45.989 µM 0.463062310086602 0.292532242906125 no 1021 0.321659852328328 1524 17385451 SGTC_506 n9-isopropylolomoucine 153 µM 0.462922506594092 0.292578230365653 no 1022 0.321709957202526 1679 6610355 SGTC_287 k060-0039 29.6 µM 0.462512860615784 0.292713000113164 no 1023 0.321856790946462 1607 5861974 SGTC_1794 st048918 76.9 µM 0.461782361913044 0.292953398967138 no 1024 0.322118700360845 1567 672303 SGTC_826 1683-5028 118 µM 0.459599124153204 0.293672423315077 no 1025 0.322901993961697 1551 722377 SGTC_2015 5119600 184 µM 0.459037595111968 0.293857488453071 no 1026 0.323103584433528 1649 2828786 SGTC_1464 k208-0027 110 µM 0.458621714788399 0.293994586383569 no 1027 0.323252920115351 1622 X1464 SGTC_2862 9027634 71.43 µM 0.457364194472014 0.294409316765658 no 1028 0.323704647876257 1462 5012562 SGTC_2271 7849410 118.62 µM 0.457262244420801 0.29444295174028 no 1029 0.323741281876422 1588 972430 SGTC_2002 4023503 131 µM 0.457165998456004 0.294474706471937 no 1030 0.323775867778277 1663 4736863 YCR052W RSC6 SGTC_1886 st057356 49.9 µM 0.456501681862263 0.294693929614807 no 1031 0.32401463084489 1476 24207747 SGTC_444 curcumin 90.4 µM 0.455397822233629 0.295058367425103 no 1032 0.324411530864486 1559 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2139 5578692 56.4705 µM 0.454706920041616 0.295286573451779 no 1033 0.324660050880334 1630 650991 YMR113W FOL3 SGTC_784 4579-0127 173 µM 0.454386529844947 0.29539242637389 no 1034 0.324775322899395 1680 1948547 SGTC_1720 st037298 9.481 µM 0.45429736872101 0.295421887201142 no 1035 0.324807404840113 1533 597396 SGTC_3099 9120367 49.47 µM 0.452589881120332 0.295986339850631 no 1036 0.325422043247571 1550 24824940 SGTC_3118 9124250 49.47 µM 0.451064852082091 0.296490894446338 no 1037 0.325971404440279 1524 1504786 SGTC_270 tamoxifen 5.46 µM 0.449800214930102 0.296909597298876 no 1038 0.326427251429706 1678 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2414 st077232 92.9 µM 0.448633768253413 0.297296030408688 no 1039 0.326847934962304 1477 729801 SGTC_1738 st035555 74 µM 0.446709568819224 0.297934001799005 no 1040 0.327542386002972 1567 5331140 SGTC_3255 9139072 49.47 µM 0.445501843176191 0.298334743685747 no 1041 0.327978564040808 1557 17646060 SGTC_875 0709-0210 25.7 µM 0.444649288519114 0.298617782053237 no 1042 0.328286611122469 1607 6251364 SGTC_1118 chelidonine 707.474 nM 0.442200641371987 0.299431383024445 no 1043 0.329172011000466 1693 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_33 0986-0033 35.816 µM 0.442024313805218 0.299490009366408 no 1044 0.329235805896288 1551 2848082 SGTC_667 1498-1044 59 µM 0.441930378852908 0.299521243491025 no 1045 0.329269793369616 1605 6739982 SGTC_2705 st078069 42.8 µM 0.441694297898981 0.299599748818161 no 1046 0.329355218230123 1543 1530061 SGTC_372 0155-0182 15.9 µM 0.437448094336967 0.301013351728051 no 1047 0.33089320573482 1637 771486 SGTC_1000 4048-0884 8.67 µM 0.436012736207688 0.301491875612989 no 1048 0.331413744485383 1604 13040088 SGTC_3 0833-0587 95.581 µM 0.433747820301757 0.302247655273483 no 1049 0.332235788364762 1559 5382644 SGTC_1552 6-methylflavone 10.6 µM 0.432571558501511 0.302640497124694 no 1050 0.332663027753133 1633 689013 SGTC_1885 st057546 99.9 µM 0.432180164939355 0.302771263439279 no 1051 0.33280523715399 1642 702008 SGTC_1181 1222-0449 220 µM 0.432011254738663 0.302827704897783 no 1052 0.332866616618897 1637 658318 SGTC_1568 digitonin 820 nM 0.430448950527461 0.303349973061046 no 1053 0.333434546948602 1753 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3210 9128157 49.47 µM 0.429063176094502 0.303813565047831 no 1054 0.333938624780392 1534 17590849 SGTC_1746 st038117 42 µM 0.428761443790576 0.303914547373353 no 1055 0.334048420197793 1591 2898218 SGTC_2048 5246248 200 µM 0.428542076410073 0.303987973595667 no 1056 0.334128253294192 1650 677046 SGTC_392 N-ethylmaleimide 8.33 µM 0.427244701291406 0.304422390072967 no 1057 0.33460055283098 1567 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_349 k015-0014 24 µM 0.425885195543477 0.30487790678066 no 1058 0.335095751517144 1540 2196908 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.424319286188003 0.30540295617127 no 1059 0.335666487894715 1634 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_227 fluconazole 33.516 µM 0.422015512725276 0.306176139368064 no 1060 0.336506847292454 1558 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1105 epirubicin 18.1 µM 0.420287049036162 0.306756807053587 no 1061 0.3371378848716 1550 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_416 estradiol valerate 100 µM 0.420171555176095 0.306795623879891 no 1062 0.337180066403903 1605 13791 A steroid. SGTC_3309 9129340 25.759 µM 0.419977961901102 0.306860694332587 no 1063 0.337250776580406 1654 17158987 SGTC_2095 5432005 200 µM 0.418527492383521 0.307348418754219 no 1064 0.3377807450737 1584 783734 SGTC_1996 st072960 66.8 µM 0.417672056799607 0.307636221225332 no 1065 0.338093452660048 1672 1719405 SGTC_1296 1068-0102 11.9 µM 0.41594934627599 0.308216168672371 no 1066 0.33872353467879 1658 767053 SGTC_2622 2-methoxyxanthone 59.94 µM 0.415894914468172 0.308234500859268 no 1067 0.338743450501821 1747 71034 A hepatoprotective. SGTC_598 3937-0236 20.2 µM 0.414929391492225 0.30855976054518 no 1068 0.339096796486948 1653 1379313 SGTC_395 anisomycin 6.25 µM 0.414644298933457 0.308655829594857 no 1069 0.33920115699157 1590 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1907 st060210 83.7 µM 0.41331643320625 0.309103459567989 no 1070 0.339687395737509 1682 688793 SGTC_1400 3771-8998 51.5 µM 0.412581643572619 0.30935128263921 no 1071 0.339956576259363 1663 670767 SGTC_632 0781-2353 4.65 µM 0.41251432427884 0.309373991809157 no 1072 0.339981241880711 1641 6811515 YHR007C ERG11 SGTC_2785 7756463 72.73 µM 0.411458164916823 0.30973036684896 no 1073 0.34036830565048 1548 2201551 SGTC_3068 9116768 49.47 µM 0.409550677804622 0.310374454758977 no 1074 0.34106779208969 1589 41904888 SGTC_275 trichlorophene 5.69 µM 0.408409695163439 0.310760000740789 no 1075 0.341486458380752 1644 62616 SGTC_949 1165-0505 146 µM 0.408143995176852 0.310849812474171 no 1076 0.341583980993378 1594 6244267 SGTC_2641 levomentholum 100 µM 0.405973399960232 0.311583937337367 no 1077 0.342381072601745 1624 16666 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.405085261718305 0.311884534065466 no 1078 0.342707419796417 1627 97141 SGTC_874 0599-0792 117 µM 0.40436256931477 0.312129226978133 no 1079 0.34297306043476 1763 765305 SGTC_1038 k292-0204 154 µM 0.40426812424727 0.312161210802685 no 1080 0.343007781424157 1560 4454212 SGTC_1401 3807-4679 7.6 µM 0.404184577835948 0.312189504977228 no 1081 0.343038496828435 1625 3291456 SGTC_2090 5301565 104.445 µM 0.403645640303838 0.312372050415126 no 1082 0.34323665933163 1627 2056344 SGTC_1971 st069429 63.5 µM 0.403527100938184 0.312412207483902 no 1083 0.343280250980488 1707 1246522 YGL099W LSG1 SGTC_1866 st057638 64 µM 0.403427646215534 0.312445901049387 no 1084 0.34331682605422 1623 688802 SGTC_2385 9074692 200 µM 0.402500939005445 0.312759929008296 no 1085 0.343657698720615 1591 17046906 SGTC_1783 st039459 87.517 µM 0.401964375405422 0.312941813398643 no 1086 0.343855122188073 1762 729761 SGTC_3206 9114350 49.47 µM 0.401680543434358 0.313038045211712 no 1087 0.343959572683524 1591 17087243 SGTC_1540 guanosine 70.6 µM 0.401671350351695 0.313041162293498 no 1088 0.343962955947782 1690 6802 Guanosine is a purine nucleoside SGTC_1316 1272-0050 65.9 µM 0.400480079239997 0.313445197409214 no 1089 0.344401476521801 1629 7340392 SGTC_738 1315-0003 72.4 µM 0.399563146562036 0.313756339642666 no 1090 0.344739152518471 1710 6251474 SGTC_170 4197-0004 226 µM 0.397090976736146 0.314595879355414 no 1091 0.345650186815788 1692 218692 SGTC_1692 fluoroquinolonic acid 71 µM 0.396888407063616 0.314664713854135 no 1092 0.345724876721118 1663 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2468 5987765 72.9 µM 0.396529794460115 0.314786588554957 no 1093 0.345857116279491 1666 26772094 SGTC_1186 1319-0216 26 µM 0.395577672933572 0.315110265475311 no 1094 0.346208305383251 1792 4565136 SGTC_1787 fluconazole 80 µM 0.39332275138023 0.315877399742095 no 1095 0.347040558204553 1578 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1491 4138-0063 26.5 µM 0.391703354921104 0.316428815486362 no 1096 0.347638705435132 1717 23883227 SGTC_3086 9117350 49.47 µM 0.389658545159791 0.317125670710379 no 1097 0.348394527175116 1592 2679265 SGTC_1379 2144-0755 36.5 µM 0.389261199029172 0.317261158558995 no 1098 0.348541467967331 1759 5392327 SGTC_2794 7785382 27.27 µM 0.389119577167285 0.317309454975947 no 1099 0.348593846008833 1768 2205081 SGTC_2132 5317594 122.667 µM 0.38805771345772 0.317671674771951 no 1100 0.348986662169986 1689 794577 SGTC_3280 9140961 49.47 µM 0.387739650032825 0.317780205619064 no 1101 0.349104355174994 1626 4901226 SGTC_332 4112-0506 40.9 µM 0.386718327241813 0.318128811203872 no 1102 0.349482373322995 1666 2790355 SGTC_2558 carylophyllene oxide 100 µM 0.384183640436264 0.318994665444334 no 1103 0.35042117135594 1690 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2824 7998404 51.95 µM 0.383244449651195 0.319315746242809 no 1104 0.350769261624597 1671 837851 SGTC_3215 9129942 49.47 µM 0.382183526934546 0.319678606534286 no 1105 0.351162619854914 1769 17682944 SGTC_852 0418-0143 439 µM 0.381778367184304 0.319817226192487 no 1106 0.351312883017384 1742 5369229 SGTC_1875 nocodazole 6 µM 0.381743854754426 0.319829035294052 no 1107 0.351325683850286 1745 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2888 9058547 12.99 µM 0.381011379838323 0.320079708934702 no 1108 0.351597402213439 1603 16476514 SGTC_3250 9135583 49.47 µM 0.379450903684536 0.320614021872621 no 1109 0.352176528056727 1742 7699353 SGTC_1910 st062352 60.4 µM 0.379034247247878 0.320756749569095 no 1110 0.35233121618037 1562 2245730 SGTC_3127 9126946 49.47 µM 0.378997338132641 0.320769394244709 no 1111 0.352344920259389 1594 27243249 SGTC_2088 5278280 127.392 µM 0.377543414181466 0.32126765863931 no 1112 0.352884903717588 1674 791502 SGTC_1140 3229-1848 2.98 µM 0.377488342020928 0.32128653837756 no 1113 0.352905363204501 1749 2849525 SGTC_2666 tannic acid 100 µM 0.375263199464835 0.322049743557981 no 1114 0.353732366096521 1693 16134267 A thiamine antagonist. SGTC_1993 st073995 70.8 µM 0.375091360927834 0.322108714012136 no 1115 0.353796260882885 1673 3098394 SGTC_736 0958-0254 92.6 µM 0.372443320031676 0.323018017355151 no 1116 0.354781402657212 1717 6812352 SGTC_2362 9071156 126 µM 0.367758171862848 0.324629428698339 no 1117 0.356526780284906 1731 653133 SGTC_1454 4239-0054 42.6 µM 0.362603182706545 0.326406237042996 no 1118 0.358450666205421 1791 1340767 SGTC_1928 4'-methoxychalcone 40.3 µM 0.360246652865299 0.327219796579982 no 1119 0.359331344755253 1863 641818 SGTC_527 4476-4215 268 µM 0.359602088857283 0.327442466695578 no 1120 0.359572360631297 1709 4418754 SGTC_2303 7774051 200 µM 0.359185540336937 0.327586399591653 no 1121 0.359728146504045 1772 2953184 SGTC_1440 4100-1550 40 µM 0.357173849749138 0.328281873387443 no 1122 0.360480830672514 1699 742806 SGTC_2616 abietic acid 100 µM 0.355221532543936 0.328957390405954 no 1123 0.36121181731524 1854 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3119 9125183 49.47 µM 0.35375185907617 0.329466277885946 no 1124 0.361762427177109 1785 22695334 SGTC_1127 asiatic acid 681.4 nM 0.353718298076195 0.32947790237387 no 1125 0.361775004078287 1642 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2163 5671233 125 µM 0.352251066806246 0.329986266659698 no 1126 0.362324991115475 1800 701023 SGTC_979 1426-2828 121 µM 0.349971078376949 0.33077685702621 no 1127 0.363180201439174 1780 747872 SGTC_1046 2001-0062 216 µM 0.349070616222687 0.331089302302706 no 1128 0.363518147791532 1662 739778 SGTC_1892 st058411 7.36 µM 0.34753629429382 0.331621957251481 no 1129 0.364094228375947 1794 3934738 SGTC_2595 hexamethylquercetagetin 100 µM 0.342867789631371 0.33324476604284 no 1130 0.365848962346411 1726 386331 SGTC_130 0136-0219 337.655 µM 0.340782033696257 0.333970803594125 no 1131 0.366633838389895 1852 234244 SGTC_651 3253-0966 34.4 µM 0.340665268503108 0.334011467175376 no 1132 0.366677793996562 1699 781462 SGTC_988 1497-1057 103 µM 0.339809894605309 0.334309411291367 no 1133 0.36699984802273 1868 3533044 SGTC_2345 9052315 157.45 µM 0.338391461325609 0.33480371050462 no 1134 0.367534103942699 1717 6469265 SGTC_1673 st016611 27.3 µM 0.337861718790557 0.33498839001474 no 1135 0.367733698434355 1809 5226799 SGTC_2951 9072950 58.06 µM 0.337329319244467 0.33517403602357 no 1136 0.367934330020814 1781 16488155 SGTC_3092 9117248 49.47 µM 0.33655598128004 0.335443768202078 no 1137 0.368225821983859 1821 17141857 SGTC_1204 4049-0315 18.3 µM 0.33637256115141 0.335507755673478 no 1138 0.368294969121866 1817 588402 SGTC_3149 9097855 49.47 µM 0.336002955993904 0.335636709664497 no 1139 0.368434318689501 1860 25236625 YMR079W SEC14 SGTC_3220 9131269 49.47 µM 0.335497606305854 0.335813055792822 no 1140 0.368624875043614 1722 17722206 SGTC_363 0455-0021 3.06 µM 0.33222787332742 0.33695492965361 no 1141 0.369858599034345 1708 4597466 SGTC_2644 guaiazulene 100 µM 0.331924467651828 0.337060963051485 no 1142 0.369973147148449 1806 3515 A coloring agent. SGTC_260 nsc-65238 3.989 µM 0.33150888164321 0.337206221941696 no 1143 0.370130066670799 1792 3246252 SGTC_1230 0170-0365 3.77 µM 0.331407328526752 0.337241721276766 no 1144 0.370168415009412 1807 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2458 5808907 16.39 µM 0.330738554643574 0.337475536873568 no 1145 0.370420988640534 1857 2731747 SGTC_104 0074-0074 590.992 µM 0.329559995306016 0.33788773552274 no 1146 0.370866227194353 1823 3943124 SGTC_210 3551-0445 56.827 µM 0.328984533250865 0.338089072862068 no 1147 0.371083689305723 1773 2865180 YOR207C RET1 SGTC_597 k018-0003 82.8 µM 0.328358787928097 0.33830805541223 no 1148 0.371320199752101 1816 6786234 SGTC_3053 9095903 49.47 µM 0.32792936914426 0.338458364212191 no 1149 0.371482533570204 1790 17174018 SGTC_1917 st066507 28.5 µM 0.324832884855199 0.339542982622927 no 1150 0.372653777248812 1709 3156428 SGTC_418 lividomycin a 100 µM 0.324213682797892 0.339760032992298 no 1151 0.372888131863691 1840 72394 An antibiotic. SGTC_2262 9014885 67.46 µM 0.32403042321844 0.339824281602971 no 1152 0.372957500686509 1854 6457424 SGTC_568 1193-0097 7.48 µM 0.322150270997032 0.340483708901277 no 1153 0.373669427894389 1792 3646150 SGTC_1678 st019265 80.2 µM 0.321204185759486 0.3408157148203 no 1154 0.374027830152581 1901 5367020 SGTC_1610 st001799 48.1 µM 0.319512055471836 0.341409834798173 no 1155 0.374669125580267 1681 621897 SGTC_1148 3909-7663 27.7 µM 0.317030758052607 0.342281748241435 no 1156 0.375610131798187 1852 4084526 SGTC_940 3232-1287 54.8 µM 0.316946631929135 0.342311324443464 no 1157 0.375642048763386 1877 1585493 YIL048W NEO1 SGTC_2735 sertaconazole 140 nM 0.316514589830106 0.342463232620478 no 1158 0.375805976443363 1843 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_203 k066-0004 30.888 µM 0.315659180155743 0.342764074136678 no 1159 0.376130606577484 1912 6795412 SGTC_2479 5617353 43.85 µM 0.315576018777751 0.34279332672621 no 1160 0.376162171209861 1811 2731746 SGTC_1906 st060206 94.7 µM 0.313839528399611 0.343404364316183 no 1161 0.376821460349511 1872 5133468 SGTC_1334 1486-0610 236 µM 0.312070507700513 0.344027269840649 no 1162 0.377493469745546 1807 3742339 SGTC_6 0844-0013 19.835 µM 0.31184760022049 0.34410578984408 no 1163 0.377578173424585 1821 1584900 SGTC_2506 ethyl hematommate 54.16 µM 0.310654715651115 0.344526102115764 no 1164 0.378031563311308 1689 3940691 An allergen. SGTC_2110 5483698 200 µM 0.310220616818344 0.34467910430364 no 1165 0.378196596718435 1776 2848765 YHR062C RPP1 SGTC_2212 7123476 200 µM 0.308022620389112 0.345454198276892 no 1166 0.379032560014253 1826 1085715 SGTC_2757 clomiphene 4.22 µM 0.306608207516122 0.345953315164191 no 1167 0.379570802837523 1903 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_337 1315-0038 354 µM 0.306463243745136 0.346004485007371 no 1168 0.379625980778112 1761 1626437 SGTC_2994 9053520 71.4286 µM 0.306381245113434 0.346033430430247 no 1169 0.379657193218045 1871 4647384 SGTC_215 1287-0124 461.5 µM 0.30623896892693 0.346083655895442 no 1170 0.379711351920417 1899 5560863 SGTC_1237 0330-0133 46.1 µM 0.304041404761244 0.346859769916609 no 1171 0.380548173470573 1764 X1237 YHR072W ERG7 SGTC_111 0083-0039 52.457 µM 0.303635249140147 0.347003282447336 no 1172 0.380702896867293 1790 759313 SGTC_776 4476-4378 112 µM 0.302827782507723 0.347288660871395 no 1173 0.381010554781695 1767 2892008 SGTC_2815 7968870 71.43 µM 0.302275582353348 0.347483871763317 no 1174 0.38122099534929 1724 2977326 YHR190W ERG9 SGTC_1027 k015-0025 8.67 µM 0.301028366912557 0.347924929613689 no 1175 0.381696431763512 1710 3598955 SGTC_84 0443-0269 128.823 µM 0.300569094830211 0.348087395748885 no 1176 0.381871550515573 1848 6150058 SGTC_2176 5809774 33.9695 µM 0.299289487582657 0.348540200020063 no 1177 0.382359587449285 1914 2870539 SGTC_74 000s-0487 160.283 µM 0.298239382270089 0.348911953616856 no 1178 0.382760232977553 1904 677548 SGTC_3276 9139060 49.47 µM 0.297653894142833 0.349119288528991 no 1179 0.382983668137316 1809 4870619 SGTC_1410 3909-8106 77.9 µM 0.297464662879757 0.349186309338978 no 1180 0.383055891283915 1861 1039210 SGTC_425 3825-7017 13.1 µM 0.296367293072637 0.349575061960867 no 1181 0.38347480014594 1850 3397440 SGTC_2634 4'-methoxyflavone 100 µM 0.296328329665059 0.349588867984022 no 1182 0.383489676506189 1764 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2406 ethylparaben 405.7 µM 0.295514729877431 0.34987719870487 no 1183 0.383800350853695 1546 8434 A possible steroid mimic. SGTC_2933 9026794 32.47 µM 0.29431465952918 0.350302648318863 no 1184 0.384258735894345 1832 17586027 SGTC_2726 cimetidine 79.27 µM 0.293676063808687 0.350529120269665 no 1185 0.384502723247788 1848 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1634 st006576 41 µM 0.292760971662666 0.35085374168819 no 1186 0.384852430943896 1939 3915356 SGTC_2795 7780010 54.55 µM 0.292642504399647 0.350895774942965 no 1187 0.38489771074193 1799 953673 SGTC_3084 9116877 49.47 µM 0.29212218945996 0.351080408984195 no 1188 0.385096600764105 1904 27241325 SGTC_2828 7998861 71.43 µM 0.291097068298183 0.351444276634375 no 1189 0.38548854102406 1925 2988188 SGTC_986 1493-0483 84 µM 0.29025011908743 0.35174500474796 no 1190 0.385812448076535 1906 40079 SGTC_1978 st071761 42 µM 0.289595058951654 0.351977662034556 no 1191 0.386063023743432 1751 5147680 SGTC_3263 9137018 49.47 µM 0.288526690880924 0.352357232523261 no 1192 0.386471801213155 1693 43844957 SGTC_2864 9034755 47.6 µM 0.286052746998157 0.353236741026969 no 1193 0.387418861177424 1952 4930451 SGTC_1250 0485-0349 40.2 µM 0.284744324367491 0.35370221408692 no 1194 0.387920014872755 1769 6842794 YDL195W SEC31 SGTC_555 4296-0685 37 µM 0.284667608252737 0.353729512742459 no 1195 0.387949404579735 1834 2908540 YHR072W ERG7 SGTC_1132 3456-3614 2.5 µM 0.284110779384166 0.353927677212952 no 1196 0.388162743228425 1972 3125502 SGTC_1134 3477-0009 42.5 µM 0.282939948841929 0.35434448187625 no 1197 0.388611435253461 1967 3973534 SGTC_1418 3966-3099 2.4 µM 0.282692042986529 0.354432756434393 no 1198 0.388706458169069 1882 740335 SGTC_1485 3909-9022 254 µM 0.280702152379246 0.35514160156975 no 1199 0.389469428871339 1894 714516 SGTC_224 benfluorex 43.875 µM 0.279831747168865 0.355451817904514 no 1200 0.389803296808951 1914 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1776 st049249 45.9 µM 0.27975534194371 0.355479053646907 no 1201 0.389832608027802 1753 1822314 SGTC_3109 9122853 49.47 µM 0.278563187041604 0.355904109939439 no 1202 0.390290033630908 1868 1234709 SGTC_1276 0871-0068 94.2 µM 0.277894741730386 0.356142518887188 no 1203 0.390546580239061 1891 3414906 SGTC_147 4466-0538 29.23 µM 0.277610735332323 0.356243830169931 no 1204 0.390655595179176 1834 6742687 YHR072W ERG7 SGTC_2762 leflunomide 42.06 µM 0.276753731296868 0.356549603708729 no 1205 0.3909846054836 1812 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1025 k007-0731 70 µM 0.275035836810351 0.357162814989706 no 1206 0.391644352907986 1772 6256118 SGTC_2371 9071574 200 µM 0.274470726136605 0.357364614916019 no 1207 0.391861448628872 1928 45596039 SGTC_920 mycophenolic acid 780.421 nM 0.27393570869236 0.357555705375066 no 1208 0.392067014619769 1784 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1040 k898-0338 155 µM 0.271138366743531 0.358555403571688 no 1209 0.393142307002806 2003 20969351 SGTC_871 0574-0004 149 µM 0.270892399295684 0.358643352517285 no 1210 0.393236895511576 1830 9551173 SGTC_3307 9126885 69.2785 µM 0.269246594539005 0.359232024679503 no 1211 0.393869963202391 1748 24824909 SGTC_3069 9117009 49.47 µM 0.268257077796216 0.359586116492378 no 1212 0.394250721330652 1947 41904981 SGTC_997 3996-0078 137 µM 0.268074326092149 0.359651526143315 no 1213 0.394321053793406 1834 735687 SGTC_1066 ketoconazole 628 nM 0.267797356497446 0.359750665666252 no 1214 0.394427652821039 1894 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2812 7970281 58.44 µM 0.267098131722412 0.360000990748233 no 1215 0.394696803012694 1921 2233435 SGTC_2205 7238770 200 µM 0.266610965112186 0.360175433716965 no 1216 0.394884356104688 1944 279867 SGTC_3005 9076496 71.4286 µM 0.266180628230024 0.360329551511802 no 1217 0.395050050723469 1936 21368410 SGTC_1479 0549-0158 134 µM 0.266134288832592 0.360346148528612 no 1218 0.395067894130501 1821 5440202 SGTC_954 1189-0853 2.85 µM 0.260646900853969 0.362313375882726 no 1219 0.397182408895708 1920 2828194 SGTC_2987 9018338 71.43 µM 0.260469016265181 0.362377208683825 no 1220 0.397251006060416 1839 5055682 SGTC_2871 9038510 12.99 µM 0.257948072191048 0.363282244718721 no 1221 0.398223491815862 1995 4945164 SGTC_2141 5621638 7.665 µM 0.256748305214197 0.363713237781176 no 1222 0.398686539480717 1960 2856238 SGTC_1483 3453-0561 55.9 µM 0.256719940515739 0.363723429339621 no 1223 0.398697488508022 1923 4546991 SGTC_2417 cerulenin 830 nM 0.256571791118392 0.363776661623689 no 1224 0.398754676796005 1841 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_370 0180-0345 38.7 µM 0.255774028666595 0.364063354728788 no 1225 0.399062664554125 1813 3989527 SGTC_3080 9117754 49.47 µM 0.254999378312325 0.364341814830118 no 1226 0.399361789699142 1961 9550191 SGTC_126 0417-1624 672.48 µM 0.254267230921993 0.364605062416131 no 1227 0.399644556980674 1999 41912 YDL195W SEC31 SGTC_769 0302-0231 76 µM 0.254069343022166 0.36467622505735 no 1228 0.399720993563478 1879 571869 YER009W NTF2 SGTC_2339 9000433 200 µM 0.25361957361075 0.364837984370079 no 1229 0.399894736700891 1769 2988954 SGTC_3070 9117005 49.47 µM 0.253326338167893 0.364943459289852 no 1230 0.40000802241141 1921 8779016 SGTC_571 k831-0106 44.2 µM 0.252697633614645 0.365169634749524 no 1231 0.400250938326875 1984 4783639 SGTC_2064 5220758 200 µM 0.249847847573757 0.366195427906447 no 1232 0.401352507927924 1880 788518 SGTC_867 0518-0118 155 µM 0.249774108736097 0.366221983261178 no 1233 0.401381021732303 2018 6848158 SGTC_2133 5320837 200 µM 0.249494808223938 0.366322572756659 no 1234 0.401489028197578 1938 2841355 SGTC_452 diindolylmethane 8 µM 0.247652904773284 0.366986160164477 no 1235 0.402201486689182 1916 3071 Inhibits expression of several cancer promoting factors. SGTC_2528 xanthyletin 44.79 µM 0.246349762467784 0.367455886977684 no 1236 0.402705745856033 1831 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1785 bathophenanthroline 24 µM 0.244920167549256 0.367971422715217 no 1237 0.403259122868704 1799 72812 An iron chelator. SGTC_1253 0550-0034 176 µM 0.24377988978509 0.368382796477307 no 1238 0.40370064807556 1877 5969915 SGTC_1722 st034304 3.6505 µM 0.242622798051239 0.368800390435865 no 1239 0.404148809270339 1844 4036148 YLR033W RSC58 SGTC_3009 9080819 71.4286 µM 0.241196795539538 0.369315247306122 no 1240 0.404701297193415 1854 17027216 SGTC_584 0986-0246 15.4 µM 0.239055519065823 0.37008879334519 no 1241 0.405531266246197 1993 53315 YDR232W HEM1 SGTC_1643 st009866 20.2 µM 0.237630322832895 0.37060394374437 no 1242 0.406083914927448 1974 3156273 YOR207C RET1 SGTC_3285 9112818 20.8695 µM 0.236326849207939 0.371075299615916 no 1243 0.406589527128319 1902 17017947 YPR165W RHO1 SGTC_1958 st076513 41.9 µM 0.235200031703132 0.371482929912154 no 1244 0.407026740695482 1862 732122 YGL099W LSG1 SGTC_772 k072-0172 35.3 µM 0.235195978950225 0.371484396270603 no 1245 0.407028313403202 1770 5861980 SGTC_3342 9147791 14.508 µM 0.233071418742726 0.372253356421615 no 1246 0.40785297415624 1903 1838168 SGTC_1044 1222-0021 1.78 µM 0.230927221976973 0.373029940585226 no 1247 0.408685671077776 1938 4306703 SGTC_1492 4158-0558 28.5 µM 0.23050955635567 0.373181270686024 no 1248 0.408847919257363 1989 3967268 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.228853622628206 0.373781446871379 no 1249 0.409491343862726 1904 364106 SGTC_2949 9072542 2.23 µM 0.227562499686949 0.374249613653247 no 1250 0.40999318798454 1852 16457352 SGTC_3175 9106517 49.47 µM 0.226111695650447 0.374775902808745 no 1251 0.410557274163179 1889 41468073 SGTC_2474 5321570 43.32 µM 0.224701344020378 0.375287741242167 no 1252 0.411105809484496 2002 2841384 SGTC_136 0097-0015 404.482 µM 0.222124672463061 0.376223421876262 no 1253 0.412108415865041 2043 4861337 SGTC_3002 9075603 71.4286 µM 0.221462781209366 0.37646389575346 no 1254 0.412366056697794 2015 20105405 SGTC_1733 st037357 54.9 µM 0.219563661107726 0.37715413718501 no 1255 0.413105497506745 1788 1272339 YGL099W LSG1 SGTC_2060 5238662 140 µM 0.219090077287653 0.377326324038047 no 1256 0.413289940094839 1895 790130 SGTC_3356 9151811 4.48 µM 0.218829289466393 0.377421152376872 no 1257 0.413391515042232 1897 1859254 YPR165W RHO1 SGTC_675 1309-0189 238 µM 0.218537570415109 0.377527236766598 no 1258 0.413505144345931 1893 4246530 SGTC_1190 1486-1332 13 µM 0.218239447063875 0.377635659643574 no 1259 0.413621275712884 1985 4150046 SGTC_468 gf-109203x 121 µM 0.21815883852194 0.377664977386765 no 1260 0.413652677369714 2041 2396 A protein kinase C inhibitor. SGTC_1997 st073024 93.8 µM 0.217931049171951 0.377747829359779 no 1261 0.413741417389091 2032 686268 SGTC_3130 9127414 49.47 µM 0.217856253601805 0.377775035372799 no 1262 0.413770556500472 2059 1494646 SGTC_1838 st055369 84.5 µM 0.21660884982419 0.378228853172409 no 1263 0.41425659415859 2015 676036 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.215368459442596 0.378680286070949 no 1264 0.414740029361477 1884 279621 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.213830100809071 0.379240392768567 no 1265 0.415339775373226 1974 88881 An O-methylated flavonoid and antioxidant. SGTC_2287 7945887 168.79 µM 0.21184675251402 0.379962891507705 no 1266 0.416113296486923 2055 1245853 SGTC_1169 aniline yellow 25.8 µM 0.207728363747213 0.38146448401925 no 1267 0.417720534831551 1979 6051 A DNA damaging agent. SGTC_1641 st009299 47.1 µM 0.206486861236964 0.381917495640524 no 1268 0.418205313411569 2032 4046054 SGTC_181 1447-1644 8.07 µM 0.20492223799902 0.382488641023177 no 1269 0.418816440244217 2051 534600 SGTC_258 haloperidol 50.781 µM 0.204853058187795 0.382513900126503 no 1270 0.418843465749689 1880 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2956 9076196 2.52 µM 0.202506294202394 0.383371051802716 no 1271 0.419760469142609 2059 16423868 SGTC_2904 7225135 42.03 µM 0.201478128926768 0.383746767672839 no 1272 0.420162364682899 2068 4446116 SGTC_1058 3448-5425 97.3 µM 0.200545797363732 0.384087558161405 no 1273 0.420526872148548 2052 7279705 SGTC_622 1348-1566 26.3 µM 0.199600858822565 0.384433048284317 no 1274 0.420896378028064 2000 7340407 SGTC_734 2023-0417 80 µM 0.196098335101055 0.385714446232126 no 1275 0.422266599679448 2001 3935732 SGTC_2233 sulbentine 40.3845 µM 0.195474375721974 0.385942853097619 no 1276 0.422510797972413 2016 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2032 5185112 25.99 µM 0.194444373945722 0.38631998251974 no 1277 0.422913973754664 2035 5718189 SGTC_2044 5102272 200 µM 0.193933603345215 0.38650703819941 no 1278 0.423113935753245 1980 592666 SGTC_1724 st037281 8.293 µM 0.193681059425805 0.386599535208847 no 1279 0.423212811699399 1923 574124 YDL195W SEC31 SGTC_1266 0828-0227 32.9 µM 0.193139737509058 0.386797822060641 no 1280 0.423424766236917 1987 3913820 SGTC_2993 9054257 71.4286 µM 0.191649343946405 0.387343907519328 no 1281 0.424008443995964 2005 6470217 YGL055W OLE1 SGTC_1766 st045414 44.774 µM 0.191310058322551 0.387468254167977 no 1282 0.424141340614946 1995 253960 SGTC_1852 st056254 31.4 µM 0.190570288308878 0.387739416549695 no 1283 0.424431135017688 1986 442583 SGTC_188 3229-0966 278.469 µM 0.188719400014785 0.38841809849348 no 1284 0.425156372894895 2077 5722370 SGTC_3128 9127691 49.47 µM 0.188117060127877 0.388639037509792 no 1285 0.425392443897832 1996 41316314 SGTC_3143 9086658 49.47 µM 0.188096584856732 0.388646548498181 no 1286 0.425400469103129 1921 25236626 SGTC_744 1594-0068 283 µM 0.185201900222351 0.389708829701983 no 1287 0.426535339356811 1947 668392 SGTC_1461 k072-0203 53.8 µM 0.184463050499478 0.389980102568711 no 1288 0.42682510558005 2090 5418714 SGTC_1826 st055655 41.6 µM 0.183684868557871 0.39026587442994 no 1289 0.427130340035005 1959 676168 SGTC_1173 0443-0020 122 µM 0.182983181075921 0.390523606072301 no 1290 0.42740560768227 1935 5331295 SGTC_741 4582-0002 126 µM 0.182828190748656 0.390580540914793 no 1291 0.42746641419686 1942 2912688 SGTC_2028 5153890 36.43 µM 0.182336266016287 0.390761262289169 no 1292 0.427659419765933 1974 2830968 YPR165W RHO1 SGTC_2581 avocatin a 64 µM 0.181557828984095 0.391047289627875 no 1293 0.427964873151479 1979 6710728 A skin care supplement. SGTC_1710 st031758 61.5 µM 0.18142257546807 0.391096992922663 no 1294 0.428017950116649 2088 5394341 SGTC_1421 4029-0249 71.4 µM 0.178966529562041 0.391999855357689 no 1295 0.428981991445275 2113 2894095 SGTC_3185 9108267 49.47 µM 0.176993978409557 0.39272540276426 no 1296 0.429756559720264 1944 4910486 SGTC_252 miconazole 1.30953 nM 0.176725958844041 0.392824015049467 no 1297 0.429861824798469 2069 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3007 9078383 71.4286 µM 0.176031111300766 0.393079701930141 no 1298 0.430134750393617 1968 6496995 SGTC_3317 9138495 8.753 µM 0.174683160592261 0.393575846244861 no 1299 0.430664300110824 2127 17020139 SGTC_2638 epoxomicin 18 µM 0.174289941461444 0.393720612205964 no 1300 0.43081880190724 2106 9915668 A protesome inhibitor. SGTC_348 k064-0012 10.7 µM 0.174256663530072 0.393732864348759 no 1301 0.430831877800562 2005 5066323 SGTC_3036 9090181 49.47 µM 0.173065970107028 0.394171318481453 no 1302 0.431299786601839 2011 25236586 SGTC_1883 5-benzylidenerhodanine 20 µM 0.172554895513108 0.394359554845476 no 1303 0.431500654062186 2105 1273210 SGTC_96 0929-0093 37.281 µM 0.171871440165294 0.394611320155283 no 1304 0.431769299943396 1960 6991579 SGTC_3205 9113483 49.47 µM 0.170128893678576 0.395253423191448 no 1305 0.432454385435102 2083 17018033 SGTC_438 sphingosine 6.67 µM 0.1686515546423 0.395798024075589 no 1306 0.433035363298053 1838 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1398 3558-0053 112 µM 0.16861099629042 0.39581297823352 no 1307 0.433051315309607 1994 4532369 SGTC_2104 5389443 200 µM 0.168025473151415 0.396028881930939 no 1308 0.433281619647199 2075 2244536 SGTC_1432 4049-0298 68.4 µM 0.167088282863894 0.396374524472653 no 1309 0.433650292665094 2142 741646 SGTC_3161 9100388 49.47 µM 0.163659254753428 0.397639867148046 no 1310 0.434999697483351 2047 25236368 SGTC_3286 9117135 37.221 µM 0.162309067171554 0.398138395160387 no 1311 0.435531237394135 1952 3438150 SGTC_3313 9133968 57.047 µM 0.1612800404508 0.398518453099953 no 1312 0.43593642143598 2072 1494643 SGTC_474 dl-dihydrosphingosine 5 µM 0.161248841645478 0.398529977487567 no 1313 0.435948707162708 2095 3058739 A sphingolipid protein kinase C inhibitor. SGTC_479 n-linoleoylglycine 10 µM 0.161092833264322 0.398587606055345 no 1314 0.436010142376025 2007 6433346 An anti-infammatory. SGTC_1113 artemisinin 1.17947 µM 0.159765083609355 0.399078158255681 no 1315 0.436533064980499 2151 2240 An anti-malaria and mitochondrial poison. SGTC_604 1000-0114 314 µM 0.159540074828818 0.399161306126358 no 1316 0.436621693741196 2113 1572745 SGTC_2499 avocadenofuran 51.48 µM 0.158460196272336 0.399560419060382 no 1317 0.43704709155516 1944 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2628 lathosterol 100 µM 0.155744004069121 0.400564761327432 no 1318 0.438117405065899 2032 6710616 SGTC_561 1550-0330 72.9 µM 0.155526062375638 0.40064537628564 no 1319 0.438203304556515 1995 6812934 SGTC_2130 NSC 7 2.4545 µM 0.15455884454179 0.40100319375291 no 1320 0.438584558657799 2106 21448 SGTC_298 1391-0729 10 µM 0.153438348490148 0.401417819573494 no 1321 0.439026302601513 2022 3237558 SGTC_630 4356-0227 183 µM 0.152566761122785 0.401740416583793 no 1322 0.439369969425921 2116 779312 SGTC_905 2-aminofluorene 215 µM 0.152242272232464 0.401860535426925 no 1323 0.439497927055911 2148 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.151953470278994 0.401967451528047 no 1324 0.439611817361476 2064 676296 Flavone; oxidizing agent. SGTC_2674 ligustilide 100 µM 0.151871182674466 0.401997916203572 no 1325 0.439644268751306 2069 5319022 A signalling regulator. SGTC_2175 5807670 165.306 µM 0.151867699606603 0.401999205724805 no 1326 0.439645642361948 2120 241186 SGTC_1470 k295-0292 231 µM 0.151376925148906 0.402180913700028 no 1327 0.439839195378732 2109 5045612 SGTC_403 arphamenine a 50 µM 0.151348452622401 0.402191456228646 no 1328 0.439850424895923 2049 5487158 An arginine aminopeptidase inhibitor. SGTC_1765 st044815 90.4 µM 0.148016271894366 0.403425752982651 no 1329 0.441164963289722 1975 645695 SGTC_73 0327-0325 16.231 µM 0.146919732477992 0.403832141056376 no 1330 0.441597688334853 2169 53298 SGTC_2380 9035439 200 µM 0.146799614257471 0.403876664344129 no 1331 0.44164509458185 2109 6462575 SGTC_233 rapamycin 362 pM 0.145897093675854 0.40421123443297 no 1332 0.44200131297558 2146 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2797 7859098 81.82 µM 0.145110178408432 0.404503006094657 no 1333 0.442311941071898 2043 972681 SGTC_845 0330-0138 4.51 µM 0.144910511598754 0.404577046810946 no 1334 0.442390763493208 2151 9039800 SGTC_1743 st037606 46.3785 µM 0.144381314869774 0.404773300781183 no 1335 0.442599685390806 2055 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3125 9127534 49.47 µM 0.143861196616799 0.404966211319382 no 1336 0.442805038746759 2175 1639235 SGTC_1806 st050005 60.3 µM 0.143233457699543 0.405199068844347 no 1337 0.443052903407979 2001 5194765 SGTC_1121 fusaric acid 630.51 nM 0.143188247364043 0.405215840754635 no 1338 0.443070755710895 1985 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1837 st055472 66.5 µM 0.141923269692076 0.405685186481653 no 1339 0.443570306903092 2102 676091 SGTC_449 xestospongin c 11.1929 µM 0.141702433568373 0.405767137417682 no 1340 0.443657526315641 2093 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.140547937640389 0.406195630956331 no 1341 0.444113539788611 2005 6708561 SGTC_1630 st005209 31.3 µM 0.137932914955568 0.407166616807104 no 1342 0.445146718328603 2200 3367314 SGTC_1832 st054113 55 µM 0.137842500373315 0.407200198949891 no 1343 0.445182447251251 2167 1251267 SGTC_3019 9081971 49.47 µM 0.137773329513542 0.407225891125598 no 1344 0.445209781641576 2161 16451803 SGTC_469 w7 172 µM 0.136189523121406 0.407814274316213 no 1345 0.445835728668741 2188 45115570 A P450 inhibitor. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.135958299474648 0.40790019120146 no 1346 0.445927123490293 2091 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_232 clozapine 119 µM 0.13485181250078 0.408311395141363 no 1347 0.446364519742197 2145 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1508 1080-0625 72.9 µM 0.134675019633616 0.408377106072564 no 1348 0.446434412335456 2172 767111 SGTC_580 1123-0028 41 µM 0.132072809074869 0.409344601013085 no 1349 0.447463351349466 2163 1677248 YPR107C YTH1 SGTC_637 1181-0519 7.26 µM 0.131784250472965 0.409451920464176 no 1350 0.447577472098102 2150 6252091 YGR060W ERG25 SGTC_3164 9100705 49.47 µM 0.130708348514067 0.409852124964732 no 1351 0.448003013925157 2177 17174235 SGTC_3045 9092950 49.47 µM 0.130501344566859 0.409929135250938 no 1352 0.448084895215023 2182 44120432 SGTC_1817 st052116 64.4 µM 0.128815816526798 0.410556319979902 no 1353 0.448751695012559 2157 4361398 SGTC_2340 7987427 183.45 µM 0.128200170392437 0.41078545894417 no 1354 0.44899528261473 2096 2239331 SGTC_2008 4012253 172 µM 0.127951716465556 0.410877940296956 no 1355 0.449093591770515 2102 603940 SGTC_2451 5856223 45.7 µM 0.127344452729728 0.411104001325511 no 1356 0.449333889242461 2072 2179896 SGTC_2050 5263056 171 µM 0.1273088600201 0.411117252044628 no 1357 0.44934797404327 2180 763468 YGL055W OLE1 SGTC_2263 7948595 193.29 µM 0.126710966483818 0.411339855453038 no 1358 0.449584582903324 2104 2971371 SGTC_546 peri-Naphthalide 147 µM 0.126349839208497 0.411474321587778 no 1359 0.449727503177199 2137 223824 A penicillin ester. SGTC_2157 5649910 96.377 µM 0.126215109082318 0.411524491161551 no 1360 0.449780825846007 2055 2858091 SGTC_1340 1486-1359 257 µM 0.124425208086273 0.412191135109081 no 1361 0.450489307632854 2079 4309068 SGTC_1407 3909-7909 12.3 µM 0.123307869197235 0.412607413673622 no 1362 0.450931654835954 2116 4411780 SGTC_1274 0865-0114 173 µM 0.122559619070348 0.412886238602267 no 1363 0.451227916305482 2095 870624 SGTC_978 1416-0512 87.4 µM 0.122185289701468 0.413025743702091 no 1364 0.451376138139128 2086 6814003 SGTC_2729 fluphenazine 10.66 µM 0.121399571998037 0.413318600743935 no 1365 0.451687277934917 2185 3372 An atypical antipsychotic. SGTC_3034 9090421 49.47 µM 0.120837112831868 0.413528273263703 no 1366 0.451910026843219 2184 17173761 SGTC_333 3486-0131 40.1 µM 0.120512789723766 0.413649185063652 no 1367 0.45203847437483 2195 6744690 SGTC_1945 st075991 56.6 µM 0.120399027933657 0.413691598853366 no 1368 0.452083530698987 2008 1084980 SGTC_711 k292-0785 179 µM 0.119456548336001 0.414043022051904 no 1369 0.452456831437842 2159 4146315 SGTC_2226 7298446 200 µM 0.119051339686603 0.414194133735557 no 1370 0.45261734088901 2192 3283010 SGTC_1647 st011722 22.4 µM 0.118963645280685 0.414226838682026 no 1371 0.452652079027857 2159 2854783 SGTC_3294 9122953 26.2835 µM 0.11839482677059 0.414438989551352 no 1372 0.452877412294924 2188 16459826 SGTC_2728 chlorpromazine 9.18 µM 0.118056851267905 0.414565055287204 no 1373 0.453011305995143 2215 2726 A thorazine and dopamine antagonist. SGTC_53 0973-0023 39.979 µM 0.117844135568059 0.414644403306265 no 1374 0.453095579021109 2236 674768 SGTC_2321 7390090 138.78 µM 0.11501516567723 0.415700006368888 no 1375 0.454216550672736 2060 649046 SGTC_1346 1488-2224 62.4 µM 0.113919426381389 0.416109034946161 no 1376 0.454650832896075 2208 3722427 SGTC_2669 eugenol 100 µM 0.113749352935642 0.416172529830092 no 1377 0.454718244199403 2204 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1252 0493-0875 34.8 µM 0.109531988533583 0.417747728035926 no 1378 0.456390275606979 2159 3960963 SGTC_1793 st048256 72.231 µM 0.108720556376285 0.418050952640525 no 1379 0.456712068435848 2225 672022 SGTC_2768 sulfasalazine 50.2 µM 0.107500168056716 0.418507092020076 no 1380 0.457196096003022 2212 5384001 An antioxidant and salicylic acid derivative. SGTC_384 k007-0144 5.16 µM 0.106967516032696 0.418706213508835 no 1381 0.45740737515508 2123 6824886 SGTC_302 1094-0063 18.9 µM 0.106146964802387 0.419013001200942 no 1382 0.45773287453701 2141 5440289 SGTC_1028 k015-0029 4.8 µM 0.101230783326461 0.4208520883282 no 1383 0.459683630333977 2231 4588309 SGTC_1998 st075797 76.8 µM 0.100842003027136 0.420997600862151 no 1384 0.459837941586817 2240 24208315 SGTC_2323 6148992 148.28 µM 0.100826319322386 0.421003471179468 no 1385 0.459844166751904 2134 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1085 doxorubicin 7.67 µM 0.0995286930190076 0.421489225700851 no 1386 0.460359253631621 2237 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0983007667454354 0.421948998719432 no 1387 0.460846734678648 2246 4114 Related to psoralen; DNA damaging agent. SGTC_2703 st077852 53.4 µM 0.0982730680302696 0.421959371192002 no 1388 0.460857731621767 2168 6281836 SGTC_1484 3473-2379 286 µM 0.0973970773103792 0.422287435588845 no 1389 0.461205532831986 2237 671917 SGTC_2712 st079126 47.7 µM 0.0967558717784118 0.422527605552991 no 1390 0.461460134331831 2208 3152970 SGTC_245 methotrexate 289.6 µM 0.0960973421074761 0.422774294429222 no 1391 0.461721631115051 2175 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2022 5136654 200 µM 0.0954204172297713 0.423027905820439 no 1392 0.461990449733041 2140 1713771 SGTC_2053 5265679 138 µM 0.0953084820532483 0.423069845656503 no 1393 0.462034902810771 2205 764595 SGTC_1201 1889-3372 45.9 µM 0.0943751096787669 0.423419595219041 no 1394 0.462405593570806 2110 5392199 SGTC_3046 9092212 49.47 µM 0.0928292434067787 0.423998988664798 no 1395 0.463019609217118 2229 25236637 SGTC_2306 7482397 179.52 µM 0.0919298551665239 0.424336156678661 no 1396 0.463376885449218 2219 891448 SGTC_2493 resveratrol 26.09 µM 0.0919132700268169 0.424342374735287 no 1397 0.46338347406828 2233 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_342 k048-0088 23.3 µM 0.0915629221247195 0.424473730640333 no 1398 0.463522655756536 2211 6820570 SGTC_1013 4112-3890 241 µM 0.0915093816162821 0.424493805317289 no 1399 0.463543926031737 2095 705171 SGTC_3183 9108214 49.47 µM 0.0905267675103585 0.424862265028092 no 1400 0.463934311939627 2232 4974831 SGTC_202 3594-0513 34.79 µM 0.0893411533270961 0.425306932892471 no 1401 0.464405394594886 2264 708429 SGTC_1222 0366-0074 1.18 µM 0.0881624567023277 0.425749100514418 no 1402 0.464873778148667 2253 286520 SGTC_706 4262-0057 46.9 µM 0.0870534877310728 0.42616519628881 no 1403 0.465314498189351 2234 883298 SGTC_2405 ticlatone 3.52 µM 0.0869354811459583 0.426209478336822 no 1404 0.465361398198711 2284 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1056 3448-1962 115 µM 0.086816619851788 0.426254082055473 no 1405 0.465408638386201 2171 715507 SGTC_280 3448-3607 3.04 µM 0.0857836128244166 0.426641766454984 no 1406 0.465819216762526 2250 626179 SGTC_2434 5670830 169.91 µM 0.0813004156702099 0.428325113400264 no 1407 0.467601521714568 2182 1549830 SGTC_1397 3532-0190 20.1 µM 0.0784893728989429 0.429381268940247 no 1408 0.468719391671156 2208 5322280 SGTC_3261 9137475 49.47 µM 0.0780497168445123 0.42954650095864 no 1409 0.468894252627811 2270 17027690 SGTC_2378 9074213 121.43 µM 0.0775428562253375 0.429737005185507 no 1410 0.469095849773535 2254 657714 SGTC_250 brefeldin a 552.239 µM 0.0769018788441962 0.429977940795588 no 1411 0.469350801437018 2251 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_281 1672-3440 14.9 µM 0.0768899780089536 0.429982414421824 no 1412 0.469355535167424 2237 6833000 SGTC_1168 k815-0004 80.5 µM 0.0768861431974556 0.429983855962335 no 1413 0.469357060520427 2236 642433 SGTC_2937 9044753 11.33 µM 0.0765513646355705 0.430109705863056 no 1414 0.469490225376835 2264 6465530 YGL099W LSG1 SGTC_943 3253-1379 105 µM 0.0757598850726452 0.430407266942626 no 1415 0.469805065718837 2241 668464 SGTC_155 k072-0202 43.6 µM 0.0750190088067031 0.430685839251995 no 1416 0.470099793834197 2277 5857737 SGTC_2488 5268135 45.7 µM 0.0747842000700375 0.430774135440204 no 1417 0.470193206564581 2224 1270356 YLR208W SEC13 SGTC_1115 galangin 695.678 nM 0.0746324572237756 0.430831197828106 no 1418 0.470253574499545 2262 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3141 9094609 49.47 µM 0.0745445322413299 0.430864262383436 no 1419 0.470288554053686 2132 25236309 YDL196W YDL196W SGTC_1772 st048439 82.2 µM 0.0743562680701402 0.430935061537435 no 1420 0.470363452726932 2143 2927068 YDL195W SEC31 SGTC_1605 st000082 49.1 µM 0.0728144987868106 0.431514946949014 no 1421 0.47097686661048 2244 1114022 SGTC_77 0828-0286 12.516 µM 0.0727863928200616 0.431525519450695 no 1422 0.47098804959527 2277 745345 SGTC_350 k064-0020 19.8 µM 0.0720042890146442 0.431819739752841 no 1423 0.471299247286698 2280 2790705 SGTC_276 colchicine 750 µM 0.0715879135001377 0.431976391854159 no 1424 0.471464929512563 2189 2833 A microtubule depolymerizer. SGTC_1908 st060353 56.5 µM 0.0712521618546921 0.432102718794758 no 1425 0.471598533858151 2288 4227716 SGTC_898 1000-0849 28.3 µM 0.0701054399730654 0.432534226484269 no 1426 0.472054868442903 2275 6751807 SGTC_3344 9148862 3.898 µM 0.0675338816833336 0.433502187285687 no 1427 0.473078344950941 2257 4905352 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0666625494308104 0.433830256435667 no 1428 0.473425174593286 2267 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2925 9010536 32.5 µM 0.0664676256357427 0.433903654301587 no 1429 0.473502765845951 2209 2994177 SGTC_1839 st053978 48 µM 0.0645718081413595 0.434617636175382 no 1430 0.474257465847224 2302 3788398 SGTC_603 3794-0023 45.9 µM 0.0633895532072961 0.435062992116571 no 1431 0.474728152927442 2286 3802260 SGTC_1898 st060199 18.6 µM 0.0619583102775154 0.435602252142488 no 1432 0.475298015880288 2294 688866 SGTC_2883 9059145 45.46 µM 0.0602979724398874 0.436227979954138 no 1433 0.475959158384088 2285 16476510 SGTC_938 3126-1755 342 µM 0.0592870777935026 0.436609031848428 no 1434 0.476361726718584 2300 1777771 SGTC_854 0422-0053 192 µM 0.0591036992379041 0.436678161830743 no 1435 0.476434756114541 2278 3596728 SGTC_3146 9095609 49.47 µM 0.0586760887743828 0.43683936977932 no 1436 0.476605052454991 2257 17173999 SGTC_1315 1237-0019 3.69 µM 0.0583568006700436 0.436959747343019 no 1437 0.476732212084061 2305 825140 SGTC_2357 9067248 200 µM 0.0582287997076828 0.437008007730203 no 1438 0.476783190392788 2232 9150235 SGTC_823 0417-1665 178 µM 0.0581098664658393 0.437052850141832 no 1439 0.476830557685973 2225 3429856 SGTC_901 1112-0062 60.1 µM 0.0567871580058639 0.437551616544539 no 1440 0.477357371928462 2315 1908457 SGTC_2755 lomerizine 42.69 µM 0.0558236143750809 0.437915011738621 no 1441 0.477741161361391 2275 3949 A calcium channel blocker. SGTC_787 4152-0075 138 µM 0.0554108598482375 0.438070695882356 no 1442 0.477905572111665 2178 9566539 SGTC_1742 st038235 28.8875 µM 0.0553872988033501 0.438079583006114 no 1443 0.477914957195902 2243 564103 YBR002C RER2 SGTC_1773 st048542 73.5835 µM 0.055106766506715 0.438185400967841 no 1444 0.478026702722703 2258 3237138 SGTC_983 1491-0821 12.2 µM 0.0546827823460727 0.438345337961357 no 1445 0.478195593267092 2302 46495113 SGTC_455 paf C-16 10 µM 0.0536311976456616 0.43874206433743 no 1446 0.478614500073016 2298 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2144 5628481 200 µM 0.0528562493775986 0.439034464815714 no 1447 0.478923221787592 2297 2818399 SGTC_2249 haloperidol 116.36 µM 0.0514551489622248 0.439563206947734 no 1448 0.479481420209832 2313 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2083 5306046 65.942 µM 0.0497799689132312 0.440195521703414 no 1449 0.48014886469061 2282 539837 SGTC_2783 7738165 71.43 µM 0.0494733399353738 0.440311278679272 no 1450 0.480271041412416 2250 17201110 SGTC_1659 st012954 42.1 µM 0.0494616938519072 0.440315675348714 no 1451 0.480275681846384 2294 24207262 SGTC_235 0330-0087 5 mM 0.0488567617194421 0.44054406151185 no 1452 0.480516723416986 2309 46494818 YHR062C RPP1 SGTC_893 0958-0369 48.9 µM 0.0472958616810629 0.441133455117865 no 1453 0.481138713146889 2333 6819948 SGTC_391 gliotoxin 8.33 µM 0.047110152140824 0.441203587478563 no 1454 0.481212718042279 2283 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_294 k038-0071 157 µM 0.0466791870700704 0.441366346572008 no 1455 0.481384459286247 2276 24152826 SGTC_1313 1220-0047 237 µM 0.0454426197898698 0.441833405813156 no 1456 0.481877255188571 2270 3528706 SGTC_2652 actinonin 100 µM 0.0453691600007936 0.441861154589222 no 1457 0.481906531209665 2342 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1516 st013856 110 µM 0.044491101532422 0.442192855344847 no 1458 0.482256472451706 2258 5281404 A mutagen and neurotoxin. SGTC_122 0236-0016 402.397 µM 0.0443797584934951 0.442234919875225 no 1459 0.482300848065916 2325 6808838 SGTC_1662 st014054 52 µM 0.0442828906839655 0.442271516306834 no 1460 0.482339454775854 2327 2838777 SGTC_3052 9092717 49.47 µM 0.0442013962837639 0.442302305082002 no 1461 0.482371934534733 2284 25237534 SGTC_50 0929-0078 56.389 µM 0.0434048465272634 0.442603261767793 no 1462 0.482689407186994 2261 1377751 SGTC_1010 4112-3296 15.2 µM 0.0422775092292341 0.443029254944961 no 1463 0.483138737143842 2333 704384 SGTC_1172 0370-0043 85 µM 0.0419441231915335 0.443155246010957 no 1464 0.483271621054207 2286 376585 SGTC_165 k038-0023 64.381 µM 0.0407724340941477 0.443598088587102 no 1465 0.483738657742278 2339 46368543 SGTC_836 0330-0104 1.35 µM 0.0384274616847267 0.444484587311484 no 1466 0.484673432944736 2350 46494820 SGTC_3315 9136395 68.55 µM 0.0366126382903553 0.445170858208254 no 1467 0.485396933194486 2337 16876844 SGTC_2838 9002687 71.43 µM 0.0343404045680383 0.446030329142714 no 1468 0.486302852835304 2329 6457060 SGTC_1203 3992-3522 103 µM 0.0340292844308365 0.446148029966137 no 1469 0.486426899310061 2349 5322312 SGTC_60 0986-0278 202 µM 0.0326061211841058 0.446686491609126 no 1470 0.486994344214224 2294 3110598 SGTC_90 0870-0863 4.608 µM 0.0312224453946696 0.447210107222214 no 1471 0.48754606990122 2342 1738164 SGTC_889 0919-1524 82.7 µM 0.030928032834966 0.447321531796068 no 1472 0.487663466821686 2223 3905452 SGTC_3082 9117008 49.47 µM 0.0305746826916874 0.447455267616229 no 1473 0.487804366496534 2325 41448529 SGTC_614 0462-0418 107 µM 0.0301620630454427 0.447611443294261 no 1474 0.487968902030017 2326 5188303 SGTC_1430 4049-0248 69.1 µM 0.030061532804346 0.447649495012914 no 1475 0.488008989615397 2344 22774488 SGTC_549 1661-1316 519 µM 0.0289052693544051 0.44808718703984 no 1476 0.488470071521079 2344 2857282 SGTC_1326 1431-2094 10.8 µM 0.0280959037616065 0.448393601973615 no 1477 0.488792830555011 2348 616278 SGTC_1448 4255-0083 152 µM 0.0276560177929501 0.448560149814664 no 1478 0.488968251494704 2355 5399660 SGTC_1352 1496-0991 99 µM 0.0271937399098688 0.448735185361081 no 1479 0.489152604344781 2339 3000039 SGTC_1402 3909-7673 35.9 µM 0.0262267611535839 0.449101351599352 no 1480 0.489538235453512 2360 5328014 SGTC_1200 1643-0193 18.4 µM 0.0261502537569795 0.449130324541124 no 1481 0.489568747023983 2355 5403974 SGTC_2585 alliin 100 µM 0.0249844910244673 0.449571826115662 no 1482 0.490033667058833 2347 87310 A garlic compound which reacts with lipids. SGTC_157 1348-1695 65.819 µM 0.024224637732686 0.449859633949027 no 1483 0.490336712913009 2366 5380510 SGTC_442 cape 100 µM 0.023628620880838 0.450085404307729 no 1484 0.490574421179746 2357 5281787 SGTC_2399 5884133 200 µM 0.0216484396820338 0.45083560980539 no 1485 0.491364196646703 2358 722445 SGTC_1588 farnesol 29.9 µM 0.021262577007479 0.45098181711308 no 1486 0.491518098153559 2371 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1195 1502-0147 41.1 µM 0.0205889914251819 0.451237061496056 no 1487 0.491786761088091 2366 817940 SGTC_143 4032-1194 15.74 µM 0.019780813868643 0.451543333935076 no 1488 0.492109111602324 2372 1806963 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.019557341005659 0.451628027822968 no 1489 0.49219824713199 2355 75037 A free radical scavenger. SGTC_985 1493-0307 8.71 µM 0.0189562687689241 0.45185583885578 no 1490 0.492437995800725 2363 3278274 SGTC_2424 5537928 59.2 µM 0.018252409901574 0.452122626964772 no 1491 0.49271874626547 2359 5382802 SGTC_2240 6690706 185.951 µM 0.0179466343061075 0.452238533779534 no 1492 0.492840713098983 2369 805876 SGTC_3059 1327-0034 3 µM 0.0172466171140523 0.452503896502463 no 1493 0.493119936315344 2365 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_393 acivicin 6.25 µM 0.0164273267663957 0.452814500266837 no 1494 0.493446739540845 2369 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1386 3228-0095 33.8 µM 0.0159195568737893 0.453007017027757 no 1495 0.493649283925011 2362 870181 SGTC_910 3454-3003 490 µM 0.0158702717149567 0.453025703677495 no 1496 0.493668943375043 2377 820824 SGTC_81 0411-0046 9.971 µM 0.0144552120626713 0.453562272972311 no 1497 0.494233405561415 2379 12925265 SGTC_2779 methotrexate 400 µM 0.0134805948048974 0.453931882513867 no 1498 0.49462218364976 2379 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_919 tnp00227 403.569 nM 0.0124402308784015 0.454326469553648 no 1499 0.495037193931749 2370 1269246 A methoxyflavone. YNL221C POP1 SGTC_248 streptozotocin 5.23457 mM 0.0114102137463498 0.454717176694673 no 1500 0.495448082079669 2383 5300 DNA alkylating agent. SGTC_386 1509-0011 3.07 µM 0.00740070154033531 0.456238482707978 no 1501 0.497047574201868 2392 3107280 SGTC_160 3453-0671 289.699 µM 0.00739636961560778 0.456240126696163 no 1502 0.497049302342499 2388 5322268 SGTC_1821 st053465 65.6 µM 0.00534022491268145 0.457020528474637 no 1503 0.497869568621424 2388 675086 SGTC_1233 0325-0408 14.2 µM 0.00432893750912625 0.457404419708568 no 1504 0.498273009192277 2393 12874 SGTC_3159 9100096 49.47 µM 0.00376008054769588 0.457620378978039 no 1505 0.498499948426483 2402 25236875 SGTC_690 glyoxal 20.3 µM 0.0023701423876288 0.458148103736566 no 1506 0.499054450876286 2398 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_124 0136-0217 7.121 µM 0.00215078992200391 0.458231393146684 no 1507 0.499141959625386 2402 3976905 SGTC_1771 st048882 4.1505 µM 0.00163277396389089 0.458428094099447 no 1508 0.499348617720891 2399 4580403 SGTC_1077 5-fluorocytosine 377 nM 0.00159148607046451 0.458443772371692 no 1509 0.499365089185842 2399 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_664 1222-0054 14.9 µM 0.00114518150425471 0.458613251947363 no 1510 0.499543138779077 2401 6813991 SGTC_1321 1326-2144 215 µM 9.44159639876417e-05 0.459012299024115 no 1511 0.499962333480076 2392 3513030 SGTC_87 0100-0052 35.5 µM 0 0.4590481572097 no 1512 0.5 2403 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_464 bw-b 70c 158 µM -0.000391963957943708 0.459197024539275 no 1513 0.499843629008787 2408 5353454 SGTC_447 ml7 120 µM -0.000982116453513629 0.45942117436747 no 1514 0.499608192285402 2407 4216 Selective myosin light chain kinase inhibitor. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.00230104409862246 0.459922171761245 no 1515 0.499082017030081 2407 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1558 st069300 45.6 µM -0.00230868853291878 0.459925075701687 no 1516 0.499078967350131 2411 24208000 SGTC_545 4218-0007 221 µM -0.00276234874110259 0.460097414346404 no 1517 0.498897983695463 2414 2840508 SGTC_3028 9087778 49.47 µM -0.00290008261521045 0.460149738844911 no 1518 0.498843036049906 2410 17217395 SGTC_1637 st007924 17.4 µM -0.00291473503536216 0.460155305276098 no 1519 0.498837190604703 2409 683336 SGTC_2806 7952793 58.44 µM -0.00303797053657685 0.460202122556578 no 1520 0.498788026970616 2414 2972490 SGTC_2886 9058944 51.95 µM -0.00323725926938113 0.460277833697138 no 1521 0.49870852266057 2412 4949929 SGTC_1048 3161-0300 24.5 µM -0.00334549586640708 0.460318954117755 no 1522 0.498665342739639 2413 2165101 SGTC_2349 9023730 187.07 µM -0.00397235342173162 0.460557113381175 no 1523 0.498415264435122 2414 4126287 SGTC_2045 5106652 78.05 µM -0.00428889777263964 0.460677382081045 no 1524 0.498288982587769 2409 673349 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.00595766209908885 0.461311476034308 no 1525 0.497623250756289 2419 688664 SGTC_1850 st056238 17 µM -0.00618445490705501 0.461397659970699 no 1526 0.497532775183873 2411 5393177 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.00680765003677753 0.461634490778142 no 1527 0.49728416154735 2425 688801 SGTC_723 4182-0001 115 µM -0.00917274372676309 0.462533412686393 no 1528 0.496340656015908 2429 744821 YLR208W SEC13 SGTC_1210 3013-0140 750 nM -0.00920007067650432 0.462543800207184 no 1529 0.496329754600258 2423 905973 SGTC_2718 lomofungin 53.02 µM -0.0100190740339324 0.46285513160649 no 1530 0.496003034627964 2422 5351222 A RNA synthesis inhibitor. SGTC_811 0416-0114 265 µM -0.0106638595163873 0.463100252806416 no 1531 0.495745816196279 2447 6612453 SGTC_1333 1482-0047 286 µM -0.0113496578775437 0.463360980807888 no 1532 0.495472238811824 2429 3811116 SGTC_2218 6965428 192.983 µM -0.012036612586378 0.46362216421026 no 1533 0.495198202274205 2428 675684 SGTC_1258 0671-0043 57.1 µM -0.0122563470411728 0.463705711595892 no 1534 0.49511054737631 2437 4298767 SGTC_3113 9123498 49.47 µM -0.0123045468632604 0.463724038335739 no 1535 0.495091319879272 2424 8897275 SGTC_2232 chlorophetanol 41.5365 µM -0.0124711885945391 0.463787400151233 no 1536 0.495024844547886 2423 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_796 1234-0020 70.7 µM -0.0126590131531174 0.463858817367128 no 1537 0.494949919305179 2430 46495034 SGTC_831 k061-1017 217 µM -0.0138037001021712 0.464294090947058 no 1538 0.494493295280365 2445 1240153 SGTC_247 mechlorethamine 29.705 µM -0.0142419017941982 0.4644607309181 no 1539 0.494318495286558 2433 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2069 5228469 200 µM -0.014543235361594 0.464575326100575 no 1540 0.494198293036829 2443 2835210 SGTC_1563 conessine 56.1 µM -0.0149775315296023 0.464740491256325 no 1541 0.494025052807414 2437 441082 An anti-amoebic, histamine inhibitor. SGTC_2671 danthron 100 µM -0.0167906535661417 0.465430096568959 no 1542 0.493301813110597 2447 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2982 9019404 25.97 µM -0.016913115697128 0.465476677749564 no 1543 0.493252964725451 2447 22333232 SGTC_502 l-744,832 89.3 µM -0.0199158718331206 0.466618988913045 no 1544 0.492055241882244 2445 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1199 1638-0010 4.46 µM -0.0200083212302999 0.466654163007318 no 1545 0.492018367256654 2441 3111136 SGTC_2889 9059656 51.95 µM -0.0205325835606485 0.466853633288915 no 1546 0.491809259814072 2464 3949838 SGTC_2058 5236698 133 µM -0.0207024939207445 0.46691828223118 no 1547 0.491741489793103 2452 766665 SGTC_1380 2291-0730 164 µM -0.0215170342474028 0.467228217569387 no 1548 0.491416607622095 2464 2999191 SGTC_176 1486-1328 72.834 µM -0.0238431368729655 0.468113416212774 no 1549 0.490488865784833 2478 22310231 SGTC_1488 4013-0813 75.9 µM -0.0239726702879632 0.468162714845383 no 1550 0.49043720419558 2446 2910057 SGTC_492 tmb-8 126 µM -0.0241817259934235 0.468242279595359 no 1551 0.490353827206666 2443 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1026 k007-1105 30.6 µM -0.0251376315058826 0.468606104881059 no 1552 0.489972592028321 2447 7066794 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0272451259900207 0.469408326342631 no 1553 0.48913211185761 2448 2724 A muscle relaxant with antifungal properties. SGTC_704 1310-0270 142 µM -0.0275971590460286 0.469542340535398 no 1554 0.488991723778353 2492 5718033 SGTC_2860 9025725 38.96 µM -0.0285129812317456 0.469890997702634 no 1555 0.488626507356726 2472 40546248 SGTC_2161 5662504 8.5105 µM -0.0293025977074006 0.470191626394713 no 1556 0.488311627561223 2480 2859334 SGTC_3268 9137683 49.47 µM -0.0300304920266532 0.47046877082041 no 1557 0.488021367505623 2454 1953228 SGTC_3288 9119690 36.221 µM -0.0305847335746333 0.470679806872334 no 1558 0.487800358648716 2496 17595618 YKL019W RAM2 SGTC_1156 4092-0367 4.88 µM -0.0310629904587447 0.470861917207622 no 1559 0.487609652376103 2470 1357585 SGTC_2516 gossypol 71.55 µM -0.0321140988954368 0.471262178932334 no 1560 0.487190529958628 2477 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2571 chrysanthemic acid 100 µM -0.0321325288369401 0.471269197307756 no 1561 0.487183181268299 2498 2743 An insecticide. SGTC_1942 st076330 65.2 µM -0.0325836586252522 0.471440996518278 no 1562 0.487003300719597 2537 24208414 SGTC_2907 7721985 69.9 µM -0.0333336672189535 0.471726626478669 no 1563 0.486704253055798 2499 3267881 SGTC_265 mycophenolic acid 32.932 µM -0.0344696051157202 0.472159259695235 no 1564 0.486251339771362 2482 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3350 9150499 3.57 µM -0.0345310126339396 0.472182648298226 no 1565 0.486226856291342 2484 4910996 YPR165W RHO1 SGTC_872 0588-0139 234 µM -0.0345861639162465 0.47220365413765 no 1566 0.48620486724765 2476 2047100 SGTC_340 k038-0059 454 µM -0.035564208186335 0.472576181218506 no 1567 0.485814923993016 2466 23733424 SGTC_879 0831-1030 162 µM -0.0358434946779113 0.472682563010293 no 1568 0.485703575797557 2473 1549252 SGTC_647 0140-0236 81 µM -0.0383381380713645 0.473632872225855 no 1569 0.484709041670981 2510 990837 SGTC_2651 TUB2.036 5 µM -0.0389474250792751 0.473864996969948 no 1570 0.484466152742813 2510 15992207 YFL037W TUB2 SGTC_1305 1181-0477 144 µM -0.039311248035507 0.474003609628217 no 1571 0.484321119456895 2495 6252086 SGTC_145 3737-0113 38.366 µM -0.040346706825774 0.47439812553067 no 1572 0.483908358705124 2512 6849351 SGTC_2968 9090663 33.37 µM -0.0414008680817413 0.474799792972169 no 1573 0.483488160381473 2572 25236811 SGTC_2511 berberine 10.47 µM -0.042252220989434 0.475124202992359 no 1574 0.483148816685236 2490 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0426088485546966 0.475260101675429 no 1575 0.483006670885572 2491 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1626 st003712 1.76 µM -0.0431340335860303 0.475460237134158 no 1576 0.482797344828868 2530 24207035 SGTC_2390 9097792 176.6 µM -0.0441961147419819 0.475864989738563 no 1577 0.482374039507987 2499 4497149 SGTC_330 1488-0319 80.1 µM -0.0449168271829235 0.476139663032489 no 1578 0.482086802114251 2534 6846614 SGTC_2817 7995342 71.43 µM -0.0451273951765559 0.476219915499075 no 1579 0.482002882733854 2483 18879975 SGTC_839 0122-0028 230 µM -0.0457442690393357 0.476455026328544 no 1580 0.481757039564367 2499 759448 SGTC_429 1112-0049 25.5 µM -0.0468373763382805 0.476871665395479 no 1581 0.481321419849322 2514 2836170 SGTC_1636 st007707 68.9 µM -0.0472869687948976 0.477043035426163 no 1582 0.481142256930162 2514 403051 SGTC_2446 5162541 200 µM -0.0484948460930042 0.477503459927656 no 1583 0.480660935916507 2495 1549321 SGTC_2192 5915882 198.485 µM -0.0486644465315565 0.47756811146027 no 1584 0.480593354922908 2488 2876149 SGTC_2182 6325192 200 µM -0.0490568316525214 0.477717690570903 no 1585 0.480437002655127 2487 736248 SGTC_2661 dactinomycin 12.96 µM -0.0517102823790599 0.478729280179994 no 1586 0.479379772024538 2506 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1272 0839-0021 27 µM -0.0517285346317765 0.478736239068682 no 1587 0.479372500161466 2554 5027250 SGTC_541 4513-1321 94 µM -0.051965906316423 0.478826740439524 no 1588 0.479277929754948 2515 747515 SGTC_62 0180-0423 3.232 µM -0.0522351741865858 0.478929404011452 no 1589 0.479170653115372 2531 30102 YGL099W LSG1 SGTC_3102 9121669 49.47 µM -0.0533030510362405 0.479336566368357 no 1590 0.478745224642149 2533 41905072 SGTC_508 roscovitine 141 µM -0.0540758982038499 0.479631252655023 no 1591 0.478437347295694 2494 160355 A CDKinase inhibitor. SGTC_1976 st070609 63.5 µM -0.0551317887194717 0.480033881211178 no 1592 0.47801673545654 2483 682556 SGTC_1690 st023502 41.2 µM -0.0551723244364833 0.48004933856067 no 1593 0.478000588621156 2510 24207482 SGTC_195 4234-0266 16.654 µM -0.0558104011803301 0.48029265817078 no 1594 0.477746424458357 2533 2303354 SGTC_2250 alverine citrate 130 µM -0.0560347082303072 0.480378195561867 no 1595 0.477657078708717 2481 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2338 7999974 200 µM -0.0563560019466035 0.480500719482091 no 1596 0.477529103288958 2586 315925 SGTC_2539 epi(13)torulosol 80 µM -0.0574740434297632 0.480927093880574 no 1597 0.477083791131893 2573 6708597 SGTC_961 1252-1571 372 µM -0.0580280596362487 0.481138380674384 no 1598 0.476863138910761 2524 6813498 SGTC_609 0986-0026 86.3 µM -0.0586123747874002 0.481361228406071 no 1599 0.47663042698735 2505 2848610 SGTC_2418 pentamidine 31.67 µM -0.0587603897231429 0.481417679679795 no 1600 0.476571479169697 2485 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1308 1187-1617 41.4 µM -0.0606659082879125 0.482144456445727 no 1601 0.475812641448132 2503 2882570 SGTC_1895 st058434 18.3 µM -0.0607384314844205 0.48217211843658 no 1602 0.47578376213436 2506 5393175 SGTC_2134 5324836 1.464 µM -0.0611102995245126 0.482313958680744 no 1603 0.47563568332432 2545 699272 SGTC_2751 anetholtrithion 17.25 µM -0.0621297971699731 0.482702833306104 no 1604 0.475229734059222 2573 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1615 st002656 86.5 µM -0.0628367582539355 0.482972504453773 no 1605 0.474948247419188 2504 1584458 SGTC_1680 diphenhydramine 100 µM -0.0630781464658122 0.483064584064985 no 1606 0.474852138115956 2593 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0638673591247746 0.483365642305644 no 1607 0.474537921420741 2535 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3138 9097216 49.47 µM -0.0641843045602409 0.483486549070505 no 1608 0.474411737385275 2504 25237486 SGTC_172 1112-0046 2.638 µM -0.0644646373958915 0.483593490309175 no 1609 0.474300131895449 2545 2802135 YIL048W NEO1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0659438627913966 0.484157803883139 no 1610 0.473711259551147 2502 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_88 0180-0332 8.668 µM -0.066982734322776 0.484554144743441 no 1611 0.473297724170748 2499 3101745 SGTC_1435 4092-0789 56.7 µM -0.0671660846427243 0.484624096492908 no 1612 0.473224742332671 2513 2248285 SGTC_2563 tomatine 8.54 µM -0.0678360009518621 0.484879686734083 no 1613 0.472958092570365 2493 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3242 9133940 49.47 µM -0.0690999022698562 0.485361914311516 no 1614 0.472455049410761 2669 17248444 SGTC_1451 4152-0210 104 µM -0.0693607014119642 0.485461422029139 no 1615 0.472351254640439 2511 659563 SGTC_2438 5259590 200 µM -0.0698547209358558 0.485649917285646 no 1616 0.472154646251202 2599 1201127 SGTC_3304 9125678 46.087 µM -0.0701030473049253 0.485744668484553 no 1617 0.472055820636682 2554 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2504 purpurogallin 52.29 µM -0.0704273298535718 0.485868402669872 no 1618 0.471926769586546 2571 5281571 An antioxidant. SGTC_2440 5628896 157.78 µM -0.0704364516136014 0.485871883214689 no 1619 0.471923139545658 2553 5522048 SGTC_543 3844-1095 191 µM -0.0706962730402277 0.485971022441105 no 1620 0.471819743550205 2616 4230703 SGTC_2859 9028643 45.46 µM -0.0709376440556074 0.486063122380456 no 1621 0.471723691601622 2623 17151580 SGTC_231 b-estradiol 524 µM -0.0719122674220647 0.486435016933101 no 1622 0.471335863668152 2530 450 A steroid. SGTC_1234 0326-0494 15.5 µM -0.0725272852495189 0.486669700119139 no 1623 0.471091146076591 2631 1547813 SGTC_1057 3448-5381 134 µM -0.0730924368535524 0.486885359044077 no 1624 0.470866280038978 2623 5497911 SGTC_1271 0832-2808 169 µM -0.0737002617097638 0.487117306139804 no 1625 0.470624445271373 2592 3663794 SGTC_781 4335-2806 94.4 µM -0.0740280432858265 0.487242390012619 no 1626 0.470494035580173 2698 845254 SGTC_1822 st052468 42 µM -0.0745199400661848 0.487430103811788 no 1627 0.470298337700002 2561 2873678 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0745718005161552 0.487449894553786 no 1628 0.470277705780231 2546 803109 SGTC_2316 5844804 197.44 µM -0.075015171518038 0.487619092975304 no 1629 0.470101320389445 2592 776813 SGTC_2041 5107442 45.335 µM -0.0751575495151663 0.487673427477349 no 1630 0.470044679680971 2556 793005 SGTC_2610 ononetin 44.17 µM -0.0751921908474524 0.487686647388505 no 1631 0.470030898783664 2589 259632 SGTC_2640 pentamidine 10.38 µM -0.0774660122277678 0.488554417650154 no 1632 0.469126414155992 2575 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1399 3562-5772 25 µM -0.0781612418815572 0.488819752759778 no 1633 0.468849896079593 2534 23847490 SGTC_485 niflumic acid 177 µM -0.0782209346488314 0.488842534797902 no 1634 0.468826154797214 2650 4488 A COX2 inhibitor. SGTC_1361 1608-0041 5.61 µM -0.0786873563210761 0.489020548170129 no 1635 0.468640651244799 2555 X1361 SGTC_1816 st051957 91.6 µM -0.0787287396763429 0.489036342548003 no 1636 0.468624192733599 2536 674121 SGTC_1289 0976-0073 69.1 µM -0.0796591958529701 0.48939146509087 no 1637 0.468254156634108 2658 3391136 SGTC_1255 0566-0045 221 µM -0.0806560672141024 0.489771945308825 no 1638 0.467857738107547 2646 2788469 SGTC_2761 levamisole 97.89 µM -0.0807667705385944 0.489814198507566 no 1639 0.467813717487105 2568 26879 An alkaline phosphatase inhibitor. SGTC_3243 9134147 49.47 µM -0.0825691570100404 0.490502148366058 no 1640 0.467097063322603 2551 24282180 SGTC_1337 1486-1011 40.3 µM -0.082738404833373 0.490566749765793 no 1641 0.467029773453435 2558 X1337 SGTC_1519 esterone 74 µM -0.0837583740813338 0.490956074227116 no 1642 0.46662427217214 2554 698 A steroid. SGTC_377 3970-0964 33.1 µM -0.0841911204851631 0.491121257087422 no 1643 0.466452238975152 2556 16481235 SGTC_2747 doxorubicin 7.63 µM -0.0846294815800125 0.491288584673771 no 1644 0.466277980114673 2542 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1652 st011932 78 µM -0.0848730025168762 0.49138154014416 no 1645 0.466181177597319 2549 1551076 SGTC_354 2783-3500 4.88 µM -0.0859081466691765 0.491776674829406 no 1646 0.465769717675126 2575 6740761 SGTC_2906 7926292 26.41 µM -0.0869625448107259 0.492179167430998 no 1647 0.465350642094294 2639 2966319 SGTC_1462 k081-0014 26.5 µM -0.0873423709765013 0.492324159436551 no 1648 0.465199687759131 2535 3270634 SGTC_439 amiodarone 34.4 µM -0.0884866586484738 0.492760977323928 no 1649 0.464744943799924 2648 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_196 k015-0023 18.111 µM -0.089012757249668 0.492961812004524 no 1650 0.464535885773894 2565 5211998 SGTC_76 0433-0009 400.328 µM -0.0902200055052548 0.493422677746579 no 1651 0.464056193530606 2722 2841569 SGTC_1116 jasmonic acid  1.58368 µM -0.0907090243616402 0.49360936270982 no 1652 0.463861899896518 2688 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1524 corynanthine 62.1 µM -0.091110300359813 0.493762552522735 no 1653 0.463702474091439 2753 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_658 3253-0951 102 µM -0.0914245419243643 0.493882516998233 no 1654 0.463577630885728 2608 1184878 SGTC_536 3852-0578 10.6 µM -0.0923465300245592 0.494234497200775 no 1655 0.463211360333969 2712 2869208 SGTC_1260 0700-1617 7.75 µM -0.0952564474279316 0.495345421809332 no 1656 0.462055567604394 2633 2853078 SGTC_22 0964-0034 14.468 µM -0.095406802779117 0.495402824307685 no 1657 0.461995856446232 2604 138402 SGTC_3122 9126309 49.47 µM -0.0955306378955828 0.495450102011927 no 1658 0.461946678006889 2554 17591206 SGTC_1731 st035964 63 µM -0.09605130528143 0.495648882818241 no 1659 0.461739912584918 2642 6739575 SGTC_2715 st079500 56.4 µM -0.0960738997857481 0.495657508990782 no 1660 0.461730940176295 2561 28246688 SGTC_2449 5812982 45.77 µM -0.0962774192340095 0.495735209121229 no 1661 0.461650122302167 2559 776185 SGTC_3110 9122132 49.47 µM -0.0963139476500748 0.495749155042467 no 1662 0.461635616981605 2726 918317 SGTC_2401 5128683 200 µM -0.0963320714431237 0.495756074396989 no 1663 0.461628420098618 2604 708373 SGTC_3331 9141060 1.957 µM -0.0973232680075829 0.496134498197271 no 1664 0.461234839256034 2590 4906567 YPR165W RHO1 SGTC_192 3455-0609 60.9 µM -0.0981877857694849 0.496464560805718 no 1665 0.460891590570485 2685 3769639 SGTC_2804 7954240 19.48 µM -0.09908880023525 0.496808559994185 no 1666 0.460533882220481 2678 828705 SGTC_3041 9091929 49.47 µM -0.099209524753804 0.496854651711328 no 1667 0.460485956255125 2673 25236887 SGTC_459 nigericin 15.3 µM -0.100316146230003 0.497277153382419 no 1668 0.460046669657405 2683 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_802 4112-3352 742 µM -0.10053149845531 0.497359373984702 no 1669 0.459961188673757 2731 704594 SGTC_1419 3993-2473 62.6 µM -0.100785032383915 0.497456172349249 no 1670 0.459860554381623 2596 704026 SGTC_857 0438-0306 1.35 µM -0.100926910811223 0.497510341100807 no 1671 0.459804240219688 2654 4686136 SGTC_764 1951-2361 146 µM -0.103428642010946 0.498465501086616 no 1672 0.458811390502052 2604 5438930 SGTC_2691 st077356 60.2 µM -0.103491434376438 0.498489475323061 no 1673 0.45878647368462 2710 2839272 SGTC_2945 9067681 61.76 µM -0.104923967219203 0.499036420212436 no 1674 0.458218070422702 2552 16456930 SGTC_106 0092-0003 11.579 µM -0.10506380031256 0.499089808976879 no 1675 0.458162591724591 2715 1072148 SGTC_2565 isoliquiritigenin 100 µM -0.105137302556803 0.499117872397577 no 1676 0.458133430078867 2730 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2756 carbadox 75.1 µM -0.106430217164352 0.499611512423965 no 1677 0.457620509697826 2633 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_320 4092-0846 5.34 µM -0.107389009838568 0.499977583770986 no 1678 0.45724018648238 2685 1359356 SGTC_3191 9110352 49.47 µM -0.10750643237242 0.499977583770986 no 1679 0.457193611301987 2579 17122424 SGTC_2518 prenyletin 46.28 µM -0.108908870679567 0.499442126621808 no 1680 0.456637385357581 2628 3873459 A coumarin with calcium channel inhibitory activity. SGTC_201 4262-0159 12.803 µM -0.109308618398786 0.499289501316331 no 1681 0.456478855532364 2689 1341029 SGTC_3196 9111891 49.47 µM -0.10944640115814 0.499236895321241 no 1682 0.456424215982151 2556 18891510 SGTC_119 0121-0043 24.815 µM -0.109726623099541 0.499129905532618 no 1683 0.456313092859597 2591 1092378 SGTC_284 0988-0104 32.6 µM -0.109935876646159 0.499050011783787 no 1684 0.456230114763404 2681 4666532 SGTC_2277 7947813 106.88 µM -0.109937369673658 0.499049441740707 no 1685 0.456229522720176 2839 1246798 SGTC_3087 9117406 49.47 µM -0.111266626774089 0.49854192767436 no 1686 0.455702459508754 2710 42546093 SGTC_3157 9099274 49.47 µM -0.111879390235067 0.498307973621754 no 1687 0.455459519102007 2630 17217662 SGTC_451 chloral hydrate 100 µM -0.112103321100155 0.498222476606403 no 1688 0.455370742084994 2714 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1247 0448-0043 5.84 µM -0.112216462449315 0.498179279163454 no 1689 0.455325888233486 2702 3089013 YGL099W LSG1 SGTC_131 0141-0277 33.849 µM -0.112431014032347 0.498097363284276 no 1690 0.455240832788005 2718 1547771 SGTC_1940 st075990 51.1 µM -0.112988165723163 0.497884642931792 no 1691 0.455019968757311 2863 1084979 SGTC_559 1550-0661 158 µM -0.113115541287879 0.497836011060747 no 1692 0.454969476953095 2685 5830875 SGTC_1969 st069479 40.1 µM -0.113638080339542 0.497636506485694 no 1693 0.454762349560731 2704 3895485 SGTC_1851 st056236 18.9 µM -0.113651483015852 0.497631389372854 no 1694 0.454757037083171 2606 5393171 SGTC_161 4065-0411 162.148 µM -0.114260961720461 0.497398692146061 no 1695 0.454515463903064 2719 1906281 YLR208W SEC13 SGTC_1214 0358-0031 63.7 µM -0.11453994312158 0.497292178135283 no 1696 0.454404892350183 2901 4301366 SGTC_2198 6589944 200 µM -0.114661776825785 0.49724566256234 no 1697 0.454356605859659 2647 5290268 SGTC_855 0428-0020 25 µM -0.114805638700984 0.497190736778763 no 1698 0.45429958978764 2628 6812414 SGTC_611 3453-1652 23.7 µM -0.115251588522764 0.497020475588884 no 1699 0.454122854669127 2608 1560575 SGTC_773 4358-1457 44.6 µM -0.115464647663047 0.496939130970319 no 1700 0.454038420049867 2591 1186886 SGTC_1648 st011736 69.8 µM -0.116420921272025 0.496574033431732 no 1701 0.453659477678707 2729 2855514 SGTC_1475 4092-1048 11.7 µM -0.116617149613522 0.496499115380995 no 1702 0.453581723514297 2655 2881759 SGTC_3278 9139605 49.47 µM -0.11677704694553 0.496438068243513 no 1703 0.453518366584256 2830 7958859 SGTC_587 k089-0003 57 µM -0.117809809686068 0.496043772247876 no 1704 0.453109178337358 2608 9659696 SGTC_69 0096-0274 206.684 µM -0.117905648472427 0.49600718237886 no 1705 0.453071208818013 2915 6741392 SGTC_1213 1315-0166 115 µM -0.118814848352772 0.495660064666804 no 1706 0.452711022366225 2739 768401 SGTC_1932 st074806 40.9 µM -0.118972178370559 0.495599998953568 no 1707 0.452648698822998 2851 17251235 SGTC_774 k060-0086 136 µM -0.120552876682605 0.494996523112936 no 1708 0.452022597741122 2614 5911235 SGTC_1611 st001856 99.4 µM -0.120814042673413 0.494896816748422 no 1709 0.451919163568137 2632 647478 SGTC_397 arbidol 50 µM -0.121202362795995 0.494748566843634 no 1710 0.451765376337834 2761 131410 A RNA synthesis inhibitor. SGTC_413 propylparaben 100 µM -0.123124331152868 0.494014823448157 no 1711 0.451004322197308 2619 7175 A pharmaceutical preservative. SGTC_1660 st012960 28.1 µM -0.124751658248681 0.493393579987244 no 1712 0.450360079719103 2695 24207266 SGTC_2721 ifenprodil 61.44 µM -0.125751496201517 0.493011892730576 no 1713 0.449964318651038 2737 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.126668243954571 0.492661930698332 no 1714 0.44960149049507 2773 688798 SGTC_3100 9120536 49.47 µM -0.127410387616499 0.492378626678984 no 1715 0.449307797558171 2588 16421196 SGTC_1103 duloxetine 36.1 µM -0.127738583090056 0.492253343397553 no 1716 0.449177927652399 2794 60835 A selective serotonin reuptake inhibitor. SGTC_1294 1000-1494 117 µM -0.129986219578286 0.491395365927333 no 1717 0.448288664684245 2649 712797 YDL207W GLE1 SGTC_2648 atorvastatin 78.68 µM -0.130153299245458 0.491331589098663 no 1718 0.448222571003418 2673 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1420 4'-methoxyflavone 42 µM -0.130361730755944 0.491252027958629 no 1719 0.448140121299717 2621 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3201 9113999 49.47 µM -0.130728651871487 0.491111970030122 no 1720 0.447994982965208 2837 16649224 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.132057882986552 0.490604596822257 no 1721 0.447469254294677 2772 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2854 9024559 71.43 µM -0.132843416607412 0.490304762369739 no 1722 0.447158608570326 2725 3163529 SGTC_1450 4112-4260 37.6 µM -0.133202803641542 0.490167587861956 no 1723 0.447016496811099 2616 1633175 SGTC_182 3448-4371 550.524 µM -0.133756774672884 0.489956144833606 no 1724 0.446797454388279 2612 3491403 SGTC_3334 9142812 21.919 µM -0.134843343890802 0.489541424746972 no 1725 0.446367867651011 2759 45283678 SGTC_2852 9023854 51.95 µM -0.135281915036825 0.489374034756689 no 1726 0.446194491667862 2784 19798528 SGTC_1825 st052143 62.6 µM -0.136002340712587 0.489099073076345 no 1727 0.445909715269328 2765 674173 SGTC_493 zm226600 134 µM -0.136559253055546 0.488886522349963 no 1728 0.445689593017894 2821 5240098 A potassium channel opener. YCR052W RSC6 SGTC_311 1315-0136 58 µM -0.137053141020297 0.488698028096943 no 1729 0.445494395455042 2789 6759207 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.138345897333647 0.488204654706155 no 1730 0.44498352670161 2782 5393153 SGTC_1704 st028805 70.8 µM -0.138572449067783 0.488118194310824 no 1731 0.444894007842536 2688 2876101 SGTC_1427 4048-4900 550 nM -0.13934183234441 0.487824573815314 no 1732 0.444590017432915 2772 24132586 SGTC_2491 paeonol 100 µM -0.140631886600372 0.487332264032508 no 1733 0.444080378350449 2637 11092 Increases levels of cortical cytochrome oxidase. SGTC_2475 5812728 15.03 µM -0.141172985914362 0.487125775718379 no 1734 0.443866643219324 2640 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1094 duloxetine 25.4 µM -0.141649333248584 0.486944000190734 no 1735 0.443678498738747 2639 60834 A selective serotonin reuptake inhibitor. SGTC_1986 st071812 45 µM -0.142034811388875 0.486796902595589 no 1736 0.443526254455022 2663 11838594 SGTC_236 1509-0011 5.31 µM -0.142055636621468 0.486788955784429 no 1737 0.443518029783159 2721 3107280 SGTC_3075 9116269 49.47 µM -0.142294664036608 0.486697744419452 no 1738 0.443423630561231 2808 17015205 YNL244C SUI1 SGTC_1747 st037496 66.6 µM -0.142398320843707 0.486658189846933 no 1739 0.44338269432202 2670 723305 SGTC_1150 3909-7983 10.9 µM -0.143338628109483 0.486299382485158 no 1740 0.443011374988163 2685 23965914 SGTC_990 3985-0011 41.3 µM -0.143841879079402 0.486107353887305 no 1741 0.44281266600309 2742 5399565 YGL099W LSG1 SGTC_731 3966-0296 387 µM -0.143977600771753 0.486055566267984 no 1742 0.442759078661883 2668 660956 SGTC_2304 7443016 91.4 µM -0.144118369769094 0.48600185298606 no 1743 0.442703499586682 2628 939854 SGTC_1424 4048-1941 275 µM -0.144392721285777 0.485897169300148 no 1744 0.442595182076376 2768 X1424 SGTC_2184 6075246 200 µM -0.145050656931883 0.485646126261698 no 1745 0.442335438112953 2721 2267320 SGTC_1954 st077032 68.9 µM -0.14527115111557 0.485561995395609 no 1746 0.442248395575319 2744 698907 SGTC_44 0929-0055 61.211 µM -0.146355574428698 0.485148236659915 no 1747 0.441820348034329 2670 1379590 SGTC_2202 7226349 200 µM -0.147242700030273 0.484809768194472 no 1748 0.441470229062468 2647 844334 SGTC_1143 3454-2408 5.08 µM -0.14818376003841 0.484450733894029 no 1749 0.44109887396544 2641 X1143 SGTC_3063 1327-0034 4 µM -0.149103404244894 0.484099882352026 no 1750 0.440736019860671 2670 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2166 5933061 31.504 µM -0.149270290587892 0.484036215203318 no 1751 0.440670178639233 3171 2877375 SGTC_3200 9114385 49.47 µM -0.14936590198431 0.483999739633796 no 1752 0.440632458070258 2807 17018030 YLR208W SEC13 SGTC_470 aa-861 153 µM -0.149541446069906 0.483932770241164 no 1753 0.440563203892177 2685 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1727 st034309 9.9045 µM -0.150511228538469 0.483562810183833 no 1754 0.440180646278972 2982 870305 SGTC_3189 9110682 49.47 µM -0.152357495669009 0.482858521412684 no 1755 0.439452489589833 2765 17122418 SGTC_2213 7173844 200 µM -0.155156273695028 0.481790984506048 no 1756 0.438349059644117 2697 892728 SGTC_2962 9082311 13.18 µM -0.155191178769268 0.481777671484361 no 1757 0.438335301179594 2691 16459453 SGTC_899 1083-0020 478 µM -0.155792044405326 0.481548500632242 no 1758 0.438098470850505 2865 767123 SGTC_513 4245-1575 41.7 µM -0.155946583454496 0.481489560241966 no 1759 0.438037563086513 2811 719745 SGTC_890 0929-0006 47.2 µM -0.158745979372224 0.480421956505816 no 1760 0.436934505583218 2689 1378169 SGTC_325 2810-4341 181 µM -0.15951333863689 0.480129333416962 no 1761 0.436632225077601 2811 774970 SGTC_94 0334-0113 514.748 µM -0.159875349049917 0.479991288872615 no 1762 0.43648963366351 2706 6795178 SGTC_2497 7-hydroxyflavone 100 µM -0.160985122934425 0.47956811653992 no 1763 0.436052558992492 2868 5281894 SGTC_1555 citronellol 128 µM -0.161078067923884 0.479532676351545 no 1764 0.436015956963126 2702 8842 A terpine precursor. SGTC_279 1273-0055 2.93 µM -0.161255903680699 0.47946486752376 no 1765 0.435945926209949 2768 2847562 SGTC_1938 st074717 56.4 µM -0.161319404906078 0.479440654631238 no 1766 0.435920920259465 2643 17250979 SGTC_2245 6637752 200 µM -0.162913552033145 0.478832834556 no 1767 0.435293250201481 2870 681890 SGTC_2253 7938677 135.83 µM -0.165554365673044 0.477826048061202 no 1768 0.43425383125258 2909 2301972 SGTC_659 k018-0002 107 µM -0.165559628145046 0.477824041930122 no 1769 0.434251760405407 2784 6797879 YHR007C ERG11 SGTC_3279 9140807 49.47 µM -0.165976127902377 0.477665267934277 no 1770 0.434087868377589 2683 45595718 SGTC_735 3076-0345 636 µM -0.166848099002511 0.477332875082456 no 1771 0.433744785782031 2834 2888990 SGTC_1164 k060-0068 93.7 µM -0.167099559052827 0.477237022160542 no 1772 0.433645856480834 2693 5963676 SGTC_140 0062-0056 502.533 µM -0.16826018453521 0.47679462572285 no 1773 0.433189297684304 2670 3758964 SGTC_2037 5169046 200 µM -0.168576020118279 0.476674243377056 no 1774 0.4330650718808 2818 5718022 SGTC_935 2996-0153 430 µM -0.16865897765695 0.476642624039993 no 1775 0.433032443762842 2740 23738523 SGTC_2687 chenodiol 100 µM -0.168978611427735 0.476520796730617 no 1776 0.432906732533753 2801 5702181 A cholesterol synthesis inhibitor. SGTC_1063 disulfiram 1.84 µM -0.169447837170116 0.47634195693592 no 1777 0.432722199428448 2684 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2302 7771753 200 µM -0.169753289870701 0.476225539841089 no 1778 0.432602081472306 2764 2203047 SGTC_91 0417-1751 58.384 µM -0.169927392619371 0.4761591850208 no 1779 0.432533619103807 2670 6795624 SGTC_2005 4024620 188 µM -0.17085213083506 0.475806755770779 no 1780 0.432170018586827 2709 236743 SGTC_2142 5622915 118.518 µM -0.170957222328842 0.475766705286263 no 1781 0.432128700985055 2725 5322196 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.171173275615414 0.475684367909311 no 1782 0.432043760156489 2910 165506 SGTC_3180 9109287 49.47 µM -0.171576525727207 0.475530693062195 no 1783 0.431885231753463 2839 18891271 SGTC_752 1896-0090 130 µM -0.172687754987472 0.475107232885849 no 1784 0.431448434645598 2705 772567 SGTC_226 1,3-diallylurea 8.28947 mM -0.172705786546876 0.475100361764456 no 1785 0.431441347569182 2805 74537 YKL182W FAS1 SGTC_1178 0988-0033 191 µM -0.172793584473427 0.475066905517595 no 1786 0.431406840019745 2859 5392207 SGTC_1622 st003707 19.4 µM -0.172993919774255 0.474990566477298 no 1787 0.431328103443143 2835 10140899 SGTC_2461 5755302 26.15 µM -0.174646414257703 0.474360908225958 no 1788 0.430678737857206 2883 2788904 SGTC_1354 1498-1681 81 µM -0.174861004150198 0.4742791466288 no 1789 0.430594426147098 2792 5754243 SGTC_1235 benzylparaben 21.5 µM -0.175474018148451 0.474045586138729 no 1790 0.430353592268723 2804 7180 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.176198295920205 0.473769645262116 no 1791 0.430069079751462 2784 6857784 SGTC_2038 4100038 30.985 µM -0.178088321294722 0.473049628564524 no 1792 0.429326806840283 2820 3596803 SGTC_2997 9067075 71.4286 µM -0.178365358293909 0.472944096971913 no 1793 0.429218026553666 2819 27209819 SGTC_1004 4084-0029 199 µM -0.1794400080205 0.47253474912201 no 1794 0.428796109648722 2866 716894 YLR208W SEC13 SGTC_2855 9016525 58.44 µM -0.179643881553843 0.472457094341267 no 1795 0.428716076278365 2706 43811474 SGTC_2373 9071805 200 µM -0.17965884176663 0.472451396084967 no 1796 0.428710203555678 2740 10149009 SGTC_23 0213-0011 39.996 µM -0.180461386862964 0.472145719712947 no 1797 0.428395182756218 2855 627608 SGTC_2428 5615643 7.78 µM -0.181653749363101 0.47169159858011 no 1798 0.427927232312762 2848 2253075 SGTC_1463 k081-0032 34.1 µM -0.181737767901439 0.471659600805048 no 1799 0.427894262503853 2788 977755 SGTC_1084 voriconazole 435 nM -0.181813595374151 0.471630722687564 no 1800 0.427864507392388 2753 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3029 9088683 49.47 µM -0.182127042195469 0.471511351255594 no 1801 0.427741513514473 2863 25236615 SGTC_1777 st045864 34.765 µM -0.182215134797354 0.471477802994605 no 1802 0.427706947987017 2729 4691462 SGTC_1071 trifluoperazine 6.31 µM -0.18237972370807 0.471415123225533 no 1803 0.427642368539892 2869 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1725 st036284 20.55 µM -0.182567338025798 0.471343675641886 no 1804 0.427568757020658 2978 707914 SGTC_2654 protoveratrine a 100 µM -0.182688184410426 0.471297655217204 no 1805 0.427521343605582 2731 5702278 A heart drug and vasodilator. SGTC_1856 st057054 55.7 µM -0.184770648474776 0.470504677072713 no 1806 0.426704465275612 2981 1266018 SGTC_2802 7925815 54.55 µM -0.185227531991466 0.470330716666579 no 1807 0.426525287656711 2744 1262923 SGTC_2281 7943571 200 µM -0.185792372814752 0.470115658872311 no 1808 0.42630379300454 2863 1244024 SGTC_335 4077-0256 27.6 µM -0.185975375336413 0.470045984261769 no 1809 0.426232036034708 2834 3121989 SGTC_26 0302-0163 425.158 µM -0.186229267668524 0.469949321269509 no 1810 0.426132486563866 2727 3100915 SGTC_701 4424-0219 185 µM -0.186341770225576 0.46990648937285 no 1811 0.426088376574645 2861 2911779 SGTC_299 1273-0059 1.44 µM -0.186714850273182 0.469764453086722 no 1812 0.42594210601465 2838 2848077 SGTC_2960 9079389 5.97 µM -0.187927603341568 0.469302769349289 no 1813 0.425466701950457 2871 16457355 SGTC_2012 4023501 200 µM -0.188330238513624 0.46914949900454 no 1814 0.425308891270492 2805 3477460 SGTC_282 k297-0036 65.7 µM -0.188566863138525 0.469059425702038 no 1815 0.425216153108419 2882 5061378 SGTC_2125 5246583 200 µM -0.190240311110553 0.468422458070314 no 1816 0.424560412087546 2800 835267 SGTC_2772 vinpocetine 57.06 µM -0.19033076038784 0.468388032480529 no 1817 0.424524975444626 2932 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1023 4482-3888 16 µM -0.190377235571989 0.46837034381171 no 1818 0.424506767415813 2957 3303168 SGTC_780 0109-0199 192 µM -0.190659674387564 0.468262847643709 no 1819 0.424396117116909 2936 610414 SGTC_2707 st078556 66.6 µM -0.192034621860514 0.467739576050826 no 1820 0.42385754288676 2828 17250899 SGTC_981 1488-1094 54.9 µM -0.192254796172109 0.467655788212741 no 1821 0.423771312620883 2715 3449522 SGTC_2667 digitoxin 100 µM -0.193852151448336 0.467047954147917 no 1822 0.423145825255293 2831 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_197 4544-0043 41.561 µM -0.194705394633685 0.466723304938064 no 1823 0.422811794216949 2753 896523 SGTC_127 0180-0333 59.125 µM -0.19471343247112 0.466720246738367 no 1824 0.422808647795811 2717 771601 SGTC_2936 9038235 15.59 µM -0.1947837891969 0.466693477816383 no 1825 0.42278110678105 2732 4749415 SGTC_1561 5-methoxyflavone 52.9 µM -0.19560426097913 0.46638132059035 no 1826 0.422459962464908 2744 94525 SGTC_2730 imipramine 71.33 µM -0.195838053595368 0.466292375477551 no 1827 0.422368462137921 2758 3696 A tricyclic antidepressant. SGTC_2325 6158266 200 µM -0.196572463437455 0.466012984270156 no 1828 0.422081060568552 2831 3623240 SGTC_1868 st057644 42.7 µM -0.19665025904845 0.465983389499405 no 1829 0.422050618713618 2745 688665 SGTC_515 4092-1064 102 µM -0.196842291610415 0.465910337859291 no 1830 0.421975477298872 2967 717353 SGTC_2803 7707263 71.43 µM -0.197385354837213 0.465703755894459 no 1831 0.421762994661559 2781 2199229 SGTC_1267 0828-0272 9.49 µM -0.19822412013042 0.465384706654246 no 1832 0.421434858383824 2891 745334 SGTC_3033 9090887 49.47 µM -0.198660445334822 0.465218746214685 no 1833 0.421264183644435 2767 19325384 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.198950362954419 0.465108476635363 no 1834 0.421150786469188 2840 279621 SGTC_2118 5526350 200 µM -0.199052966892819 0.465069452076707 no 1835 0.421110655956776 2888 743594 SGTC_2695 st077686 51.995 µM -0.19939426031267 0.464939646368966 no 1836 0.420977174974332 2814 2876092 SGTC_3018 9082602 49.47 µM -0.199690721187271 0.464826895058346 no 1837 0.420861235519621 2744 17332089 SGTC_2284 7945075 39.21 µM -0.199805400580797 0.464783280441368 no 1838 0.420816388722404 2897 1245402 SGTC_2546 rhodinyl acetate 100 µM -0.200130110441062 0.464659789791873 no 1839 0.420689412485633 2767 6708682 SGTC_2896 9052656 71.43 µM -0.201109725248155 0.4642872524265 no 1840 0.420306388852298 2831 6469436 SGTC_1974 st069448 26.9 µM -0.201158786780679 0.464268595654313 no 1841 0.420287208062471 2901 6323587 YNR016C ACC1 SGTC_825 1988-2224 89.6 µM -0.201212195043844 0.464248286027494 no 1842 0.420266328117224 2755 1180859 SGTC_685 1278-0033 54.9 µM -0.201357830587208 0.46419290549135 no 1843 0.420209393083406 2882 3590572 SGTC_2589 lobaric acid 100 µM -0.201660326647091 0.4640778781392 no 1844 0.42009114004037 2795 73157 A novel microtubule depolymerizer. SGTC_2793 7325131 81.82 µM -0.201813814450236 0.464019513913142 no 1845 0.420031140695186 2842 4176441 SGTC_837 0091-0265 12.5 µM -0.202331787963472 0.463822558557505 no 1846 0.419828675325954 2769 759367 SGTC_3207 9114163 49.47 µM -0.203689773463477 0.463306237463495 no 1847 0.419297967129046 3031 849233 SGTC_589 1227-0070 34.1 µM -0.203730308333013 0.463290826603788 no 1848 0.41928212813058 2892 2841384 SGTC_1080 nisoldipine 24.4 µM -0.203769515316497 0.463275920642465 no 1849 0.419266808127973 2730 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2165 5727197 32.143 µM -0.205549545363694 0.462599232086411 no 1850 0.418571396387685 3186 1361712 SGTC_499 genistein 192 µM -0.205646508334509 0.4625623741516 no 1851 0.418533522747762 2831 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3245 9134821 49.47 µM -0.20649223300617 0.46224090772236 no 1852 0.41820321558925 2768 17014901 SGTC_406 estrone 100 µM -0.208502944422566 0.461476720308669 no 1853 0.417418141921327 2958 5870 A steroid. SGTC_407 eburnamonine 100 µM -0.208941900948401 0.461309910084729 no 1854 0.417246796879419 2751 3195 SGTC_3131 9127911 49.47 µM -0.209347021033071 0.46115596426755 no 1855 0.417088673709467 3019 45595681 SGTC_684 1140-0066 328 µM -0.209799814595847 0.460983909396457 no 1856 0.416911958887094 2839 6813534 SGTC_2221 6807166 181.081 µM -0.209944973241169 0.460928752798042 no 1857 0.416855310387302 2836 674925 SGTC_2215 7188065 200 µM -0.210715026408753 0.460636164747916 no 1858 0.416554824241214 2897 940217 SGTC_1089 terbinafine 2.25 µM -0.213996647885031 0.459389526440491 no 1859 0.415274835617328 2905 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_356 1634-0012 32.5 µM -0.214144499269242 0.459333369244851 no 1860 0.415217187593393 2836 735457 SGTC_1141 3253-0389 52.6 µM -0.214270296451479 0.459285589357245 no 1861 0.415168140054622 2775 5402031 SGTC_1469 k284-2957 126 µM -0.214469121781649 0.459210073349168 no 1862 0.41509062199159 2818 23884841 SGTC_2811 7967822 32.47 µM -0.214472462525653 0.459208804511074 no 1863 0.415089319529819 2929 2232244 SGTC_699 0375-0592 111 µM -0.214550309545525 0.459179237782507 no 1864 0.415058969438804 2841 762578 SGTC_1963 st076565 50.3 µM -0.215476331468184 0.458827546899186 no 1865 0.414697981705617 2803 4914280 SGTC_2480 5767542 37.17 µM -0.215956897781492 0.458645046849888 no 1866 0.414510672668715 2828 2867358 SGTC_2242 6630449 61.2675 µM -0.21699052956469 0.458252544028783 no 1867 0.414107862714712 2973 691249 YDR170C SEC7 SGTC_163 TUB2.036 7.546 µM -0.217193556793618 0.458175452911616 no 1868 0.414028752888657 2865 15992207 YJR013W GPI14 SGTC_1215 3852-0577 11.2 µM -0.217821811241681 0.457936909483552 no 1869 0.413783974831382 2950 2884876 SGTC_3353 9151644 39.2805 µM -0.218653716441636 0.457621064743167 no 1870 0.413459902715627 2910 4909158 SGTC_964 1287-0107 19.4 µM -0.219701445182793 0.457223317601459 no 1871 0.413051839536224 2935 51516812 YPR165W RHO1 SGTC_2445 5742597 35.57 µM -0.220749262669675 0.456825579619372 no 1872 0.412643835724841 2793 1774255 SGTC_746 1095-0025 46.6 µM -0.221376667165308 0.456587445652729 no 1873 0.412399579324364 2980 6749286 SGTC_955 1216-0110 33 µM -0.222064572966881 0.456326366086487 no 1874 0.412131808001437 2761 3619719 SGTC_3300 9124615 50.48 µM -0.222841933093069 0.456031358788926 no 1875 0.411829265295598 2992 24824903 SGTC_600 1495-0418 41.6 µM -0.222857932293311 0.456025287364346 no 1876 0.411823039077158 2811 5377768 SGTC_1920 st075728 45.7 µM -0.223067006743347 0.455945948108199 no 1877 0.411741678101587 2998 3400306 SGTC_1170 0310-0127 64.8 µM -0.223392020569953 0.455822615841764 no 1878 0.411615207045094 2880 774975 SGTC_1297 1068-0111 14.1 µM -0.224021224380559 0.455583865393382 no 1879 0.411370394118957 2789 767057 SGTC_793 0488-0545 106 µM -0.224929393924519 0.455239290117846 no 1880 0.411017101050218 2786 292548 SGTC_3336 9143619 71.43 µM -0.225198376239392 0.455137240014299 no 1881 0.410912476291649 2822 45595730 SGTC_2387 9077560 195.08 µM -0.225718184593809 0.454940036571833 no 1882 0.410710306897182 2804 5303272 SGTC_68 0986-0284 82.829 µM -0.225893226256876 0.45487363225112 no 1883 0.410642233167519 2999 423278 YIL048W NEO1 SGTC_1681 tripelennamine 100 µM -0.226087372479601 0.454799981843431 no 1884 0.410566732820076 2785 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_913 3487-1245 167 µM -0.227148079632081 0.454397624413658 no 1885 0.410154299429601 2772 4016153 SGTC_1061 3448-9325 110 µM -0.227160284708877 0.454392994940446 no 1886 0.410149554322745 2778 723482 SGTC_63 0099-0242 26.702 µM -0.228586717664638 0.453851981524382 no 1887 0.409595074515166 2958 3898502 YLR359W ADE13 SGTC_688 0527-0193 473 µM -0.229486718329401 0.453510675833275 no 1888 0.409245321222561 2850 4007154 SGTC_1251 0490-5699 265 µM -0.230032043932369 0.453303889639149 no 1889 0.409033434920164 2949 3883818 SGTC_2976 9009005 19.48 µM -0.230062546495166 0.453292323512004 no 1890 0.40902158393152 3028 2993148 SGTC_1409 3909-8004 61.9 µM -0.231138369838884 0.452884412397011 no 1891 0.408603653626582 2848 2119279 SGTC_873 0591-4978 488 µM -0.231956173680975 0.452574365656884 no 1892 0.408286026900206 3029 3305145 SGTC_1228 0124-0032 52.5 µM -0.232347421702209 0.452426045467787 no 1893 0.408134091426371 2887 X1228 SGTC_185 k048-0037 25.491 µM -0.233402660047616 0.452026042987409 no 1894 0.407724373896473 2950 6827589 SGTC_2790 5423970 71.43 µM -0.234312400791455 0.451681232426429 no 1895 0.407371229713471 2997 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3027 9089541 49.47 µM -0.234653027740427 0.451552137131095 no 1896 0.40723902411464 2916 9943819 SGTC_697 0508-1955 564 µM -0.235496603266612 0.451232449831881 no 1897 0.406911657466349 2953 6243113 SGTC_636 0kpi-0074 126 µM -0.235516479285591 0.451224917856868 no 1898 0.406903944956009 2908 616434 SGTC_660 4031-1742 102 µM -0.238366888898435 0.450144944369591 no 1899 0.405798273089494 2810 6738706 SGTC_2346 9031566 143.75 µM -0.238392511003909 0.450135238235586 no 1900 0.405788337685885 2940 4771086 SGTC_3347 9188721 44.724 µM -0.238638456861153 0.450042070851157 no 1901 0.405692971118953 2911 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_613 3914-0030 117 µM -0.240459972479113 0.44935214386866 no 1902 0.404986845173908 2771 1145395 SGTC_1600 coumarin 106 71.1 µM -0.240501809329571 0.449336299310333 no 1903 0.40497063038894 2987 100336 A hepatotoxic, DNA x-linker. SGTC_2285 7945142 200 µM -0.242123207461245 0.44872230176503 no 1904 0.404342348080907 2952 2970608 SGTC_1877 wortmannin 25 µM -0.242600253085644 0.448541675528426 no 1905 0.40415754256834 2974 312145 A covalent inhibitor of PI 3-kinase. SGTC_3058 9093861 49.47 µM -0.242605069046547 0.448539852090719 no 1906 0.404155676993873 3016 17217477 SGTC_848 0368-0089 85.6 µM -0.245246380882186 0.447539953253196 no 1907 0.403132832960876 2952 762535 SGTC_911 3456-4043 236 µM -0.24600454485479 0.447253002887559 no 1908 0.402839357157204 2937 914281 SGTC_1175 0741-0056 27.6 µM -0.246684876891423 0.446995533898895 no 1909 0.402576055711143 3049 765927 SGTC_1370 2001-0092 44.6 µM -0.248787134382827 0.446200084434066 no 1910 0.401762721774062 3051 790957 SGTC_458 nppb 133 µM -0.250212109708794 0.445661027008939 no 1911 0.401211660430548 3039 4549 A chloride channel blocker. SGTC_984 1492-0255 2.91 µM -0.250489876282191 0.445555961673955 no 1912 0.401104266383695 2975 1585198 SGTC_376 3970-0862 59.1 µM -0.251162284739604 0.445301638708777 no 1913 0.400844321254492 2974 3135186 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.251711549670942 0.44509390863615 no 1914 0.400632014520124 3048 6728940 SGTC_692 k241-0027 77.8 µM -0.25226392110457 0.444885018899448 no 1915 0.400418536633346 3023 3600480 SGTC_133 0724-0033 378.92 µM -0.252678900910114 0.444728096477952 no 1916 0.40025817677393 2793 280309 SGTC_1153 4055-0057 267 µM -0.255297569117681 0.443738061712671 no 1917 0.399246638658955 2858 882706 SGTC_2984 9022109 38.96 µM -0.255502207396213 0.443660709227613 no 1918 0.399167619460661 2955 6459207 SGTC_189 3970-0742 2.116 µM -0.256405869342324 0.443319154183013 no 1919 0.398818728117124 2881 2891807 SGTC_3262 9137218 49.47 µM -0.258448347782081 0.442547318797167 no 1920 0.398030453744984 2791 17650664 SGTC_1685 st024049 53.0905 µM -0.259189170585065 0.442267421828406 no 1921 0.397744643150372 2957 1941139 SGTC_1160 4092-0570 10.5 µM -0.259504097951243 0.442148444990725 no 1922 0.397623160293968 2867 4994975 SGTC_517 1365-0151 113 µM -0.259578305704615 0.442120410702009 no 1923 0.397594536186351 3039 768657 SGTC_1030 k029-0042 36.7 µM -0.260392682065821 0.441812773758819 no 1924 0.39728044359107 2918 6080581 SGTC_1951 sophoraflavanone G 9.2 µM -0.260684525424315 0.441702536214455 no 1925 0.397167900239323 2849 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1703 st026983 48.3 µM -0.261398703591465 0.441432789852388 no 1926 0.396892528338747 3019 1104023 SGTC_3326 9140064 16.379 µM -0.261641023669581 0.441341271294219 no 1927 0.396799106547028 2853 1868434 SGTC_1931 st074438 57.1 µM -0.262021752343962 0.441197485413274 no 1928 0.396652335979266 2808 2787313 SGTC_2482 5981709 142.65 µM -0.264277353963326 0.440345795158906 no 1929 0.395783104524691 2921 877755 SGTC_1323 1348-1351 11.2 µM -0.264802562576849 0.440147521647484 no 1930 0.395580781347891 2897 6989654 SGTC_264 promethazine 12.5 mM -0.265103313405745 0.440033990806864 no 1931 0.395464937453756 2901 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2629 bisabolol 100 µM -0.266657510020708 0.439447373783831 no 1932 0.394866435839971 3020 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2602 kawain 100 µM -0.266942163507673 0.439339948344886 no 1933 0.394756846183748 2851 5369129 SGTC_1238 0333-0287 48.8 µM -0.267174919833777 0.439252111705647 no 1934 0.394667242769207 2880 7226 SGTC_579 4491-1009 110 µM -0.269608952032779 0.438333746481827 no 1935 0.393730556291148 2977 1271041 SGTC_1353 1498-1206 8.11 µM -0.270648013891788 0.437941807177541 no 1936 0.393330881876281 2892 6756808 SGTC_1060 3448-7350 82 µM -0.271800191281077 0.437507271319784 no 1937 0.392887829066757 3012 570178 SGTC_2789 5281112 71.43 µM -0.272074878053161 0.437403686179521 no 1938 0.39278222278135 2931 765948 SGTC_3178 9107506 49.47 µM -0.272453437023721 0.437260937578458 no 1939 0.392636694646155 3035 8897194 SGTC_411 enrofloxacin 100 µM -0.273053209406835 0.437034789624931 no 1940 0.392406156927602 3045 71188 A bacterial gyrase inhibitor. SGTC_2103 5378138 10 µM -0.273200591318968 0.436979221492992 no 1941 0.392349512729054 2896 244142 SGTC_2107 5363541 170.161 µM -0.273386052542382 0.436909297896644 no 1942 0.392278236515034 2949 244052 SGTC_1124 fisetin 1.16336 µM -0.273446975992484 0.436886328637019 no 1943 0.392254823283066 2951 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1897 st060201 15 µM -0.275217794752712 0.436218790720982 no 1944 0.391574458219601 2914 611878 SGTC_105 0111-0055 734.78 µM -0.276011087836004 0.435919805240961 no 1945 0.391269775027056 2976 5179370 SGTC_1434 4073-0095 163 µM -0.27605623918834 0.435902789176417 no 1946 0.391252435574381 2923 24133745 SGTC_1594 piperine 70.1 µM -0.276788464348515 0.435626854103612 no 1947 0.39097126968455 2879 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3355 9151058 44.0485 µM -0.27693423929559 0.435571923343041 no 1948 0.390915300607876 2899 17015728 SGTC_1487 3970-0795 2.82 µM -0.277445336328876 0.435379342128487 no 1949 0.390719087014361 2987 3765103 SGTC_2939 9044578 71.43 µM -0.277594161598223 0.435323267688944 no 1950 0.390661957219084 2871 2653634 SGTC_3240 9133527 49.47 µM -0.278286337263491 0.435062486596094 no 1951 0.390396281667825 2924 17617455 SGTC_7 0192-1582 4.227 µM -0.279542581162485 0.434589261832095 no 1952 0.389914232419563 2950 252616 SGTC_1691 st019933 84.6 µM -0.279975697067427 0.434426129555228 no 1953 0.389748075233775 2970 6176082 SGTC_3155 9099265 49.47 µM -0.280243002575357 0.434325455016994 no 1954 0.389645538299418 3003 25236499 SGTC_679 0422-0091 41.4 µM -0.281627483491402 0.433804090076926 no 1955 0.389114582038682 2896 627384 YHR062C RPP1 SGTC_2663 amphotericin b 100 µM -0.282128342957829 0.433615505777868 no 1956 0.388922550536239 2926 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_894 0960-0238 55.9 µM -0.282606615304135 0.43343544011668 no 1957 0.388739204350016 2932 6741907 YDL195W SEC31 SGTC_1988 st071872 53.4 µM -0.28288592937815 0.433330287020172 no 1958 0.388632140477203 3033 16414116 SGTC_2398 5228213 48.84 µM -0.283161428654593 0.433226574699951 no 1959 0.388526547141047 3113 80771 YMR134W ERG29 SGTC_2686 alizarin 95.37 µM -0.283499268495812 0.43309940041205 no 1960 0.388397071163826 2959 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1343 1487-0095 224 µM -0.28542216504297 0.432375689745036 no 1961 0.387660364114805 3031 4560101 YGL055W OLE1 SGTC_2697 mebhydrolin 72.4 µM -0.28896627756232 0.431042406401728 no 1962 0.386303591899533 3066 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3319 9138450 16.7555 µM -0.289601711933474 0.430803440705323 no 1963 0.386060478584739 2924 2029690 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.289921040506629 0.430683361426714 no 1964 0.3859383223036 3020 616764 SGTC_37 0566-0070 1.56 µM -0.290399798657561 0.430503342777826 no 1965 0.385755198858412 3016 1626686 SGTC_528 3492-0019 172 µM -0.290665365642755 0.430403492718689 no 1966 0.385653631319966 2991 2869262 SGTC_616 4092-0450 108 µM -0.291734857758988 0.430001421385617 no 1967 0.385244677668634 2976 787165 SGTC_1332 1480-0653 17.5 µM -0.291862283105611 0.42995352116107 no 1968 0.38519596111222 3052 5749438 SGTC_761 k216-0224 480 µM -0.292805865432529 0.429598853016228 no 1969 0.384835272345178 3114 1340404 SGTC_931 2812-0076 566 µM -0.294362370534207 0.429013927369009 no 1970 0.384240508858631 2892 3450959 SGTC_916 4466-0038 42 nM -0.294721538568549 0.428878976176083 no 1971 0.384103304110562 3116 5722064 YGL116W CDC20 SGTC_86 0417-1630 471.922 µM -0.295112343043124 0.428732147581528 no 1972 0.383954030515614 2999 3634867 SGTC_51 1013-0126 23.419 µM -0.295176905663291 0.428707891799871 no 1973 0.383929371516731 3201 1627850 SGTC_2942 9052777 62.25 µM -0.298759417099752 0.427362388721612 no 1974 0.382561808948801 2967 6469503 SGTC_1946 st076057 65.1 µM -0.299384234837609 0.427127808610031 no 1975 0.382323444819097 2904 953009 SGTC_718 1130-0073 349 µM -0.300308198393495 0.426780965137659 no 1976 0.381971040134707 3105 6740020 SGTC_3095 9117207 49.47 µM -0.300453525972085 0.426726416267477 no 1977 0.381915620303604 3046 17015229 SGTC_2426 5582046 32.21 µM -0.300752457721968 0.426614216305843 no 1978 0.381801632019724 3121 2251934 SGTC_565 1418-0001 44.5 µM -0.301351944976809 0.426389224832626 no 1979 0.381573067175142 3110 2862145 SGTC_2702 st077768 96.8 µM -0.301782275030419 0.426227733923938 no 1980 0.381409021879988 3022 6484119 SGTC_3006 9075424 71.4286 µM -0.303692731021731 0.425510942606716 no 1981 0.380680998209379 2970 7465181 SGTC_1088 bifonazole 369 nM -0.303750519870162 0.425489264409923 no 1982 0.380658982992796 2995 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3032 9089427 49.47 µM -0.303864636485632 0.425446456770042 no 1983 0.380615510307689 3043 17173707 SGTC_882 0843-0131 351 µM -0.30431121129267 0.425278945240163 no 1984 0.380445402286542 2940 5425421 SGTC_2650 prasterone 100 µM -0.305257224402748 0.424924137513398 no 1985 0.380085126017683 2954 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3229 9132204 49.47 µM -0.306140770268088 0.42459281340286 no 1986 0.379748733494303 2942 17682924 SGTC_680 0417-1641 114 µM -0.30644662099534 0.424478133715186 no 1987 0.379632308095676 2917 2835990 SGTC_712 r015-0009 80.6 µM -0.308608070796378 0.423667874119277 no 1988 0.378809840375393 3051 6813872 YLR060W FRS1 SGTC_2847 9005661 71.43 µM -0.308613620842406 0.423665793995293 no 1989 0.3788077291947 3023 2991449 SGTC_3213 9129884 49.47 µM -0.308896559085723 0.423559753257268 no 1990 0.37870010717581 3047 17190742 SGTC_933 2914-0560 114 µM -0.309408602000075 0.423367861824483 no 1991 0.378505363884489 3145 463887 SGTC_2825 7998094 58.44 µM -0.310696724856158 0.422885209824921 no 1992 0.378015593653623 3004 2987815 SGTC_2524 avocatin b 10.57 µM -0.311379901741671 0.422629274414877 no 1993 0.377755915539279 3064 6710748 SGTC_1562 morin hydrate 59.1 µM -0.313289465015129 0.421914077067661 no 1994 0.377030376635189 3129 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1074 carmofur 3.8 µM -0.314838655073159 0.421334040969161 no 1995 0.376442080301454 2973 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_542 3381-0244 89.3 µM -0.315108865281099 0.421232888339239 no 1996 0.376339498819028 3135 1112843 SGTC_1281 0884-0031 11.8 µM -0.315703059642195 0.421010471208955 no 1997 0.376113952066431 2973 1548255 SGTC_2266 7929956 200 µM -0.316083469497626 0.420868090512758 no 1998 0.375969576728419 2906 2967153 SGTC_3314 9135860 59.4275 µM -0.316400419482293 0.420749469629702 no 1999 0.375849299301718 3130 25252478 SGTC_1098 clofazimine 15.1 µM -0.316886466430519 0.420567576934705 no 2000 0.375664875727925 3085 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3332 9141069 11.198 µM -0.317282674160304 0.420419317194245 no 2001 0.37551456137424 2933 17332883 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.317421067367356 0.420367533531835 no 2002 0.375462061838783 2922 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2990 9074105 71.4286 µM -0.318050642830501 0.420131977794724 no 2003 0.375223261180212 3051 6502001 SGTC_2656 pseudo-anisatin 100 µM -0.318126461483126 0.420103612164731 no 2004 0.375194506065849 2991 6708809 A neurotoxin. SGTC_1262 0737-0114 49.6 µM -0.318340705852587 0.420023460299856 no 2005 0.375113255122216 3131 765919 SGTC_2314 7727897 200 µM -0.318920317683778 0.419806635906998 no 2006 0.374893468456274 2960 900724 SGTC_150 3970-0969 77.2 µM -0.318955210555793 0.419793583764986 no 2007 0.374880238503796 3072 6615640 SGTC_369 0957-0393 4.5 µM -0.319259553973846 0.419679743811367 no 2008 0.374764850149721 3017 6997992 SGTC_3296 9122258 64.045 µM -0.320182192891536 0.419334670933144 no 2009 0.374415110622544 3053 4730474 SGTC_2831 7999036 19.48 µM -0.32087209015749 0.41907668544516 no 2010 0.37415366264597 3223 2988270 SGTC_1831 st055328 12 µM -0.321430440981511 0.418867916912224 no 2011 0.373942108733952 3112 1103068 SGTC_334 1502-1024 68.5 µM -0.322934246093888 0.418305754838038 no 2012 0.3733725200076 3067 3296216 SGTC_530 4358-1714 28 µM -0.323413428531203 0.418126658781362 no 2013 0.373191080521211 3054 1564641 SGTC_1925 st057770 10.1 µM -0.325434851201415 0.417371332492919 no 2014 0.372425991160894 2984 5989122 SGTC_1341 1486-1360 280 µM -0.326716064277598 0.41689275110751 no 2015 0.371941324466088 2962 3976547 SGTC_1363 1636-0063 10.4 µM -0.327907713608044 0.416447735661777 no 2016 0.371490720650336 2992 6072185 SGTC_2878 9043973 25.97 µM -0.328735752639353 0.416138571667357 no 2017 0.371177714088822 3119 6465167 SGTC_624 k048-0052 28 µM -0.328755893299284 0.416131052417568 no 2018 0.371170101789945 3033 6835531 SGTC_2597 laccaic acid a 100 µM -0.330592489387581 0.415445512855214 no 2019 0.370476160062598 3115 5491415 A textile dye. SGTC_291 SEC14.278 35.5 µM -0.331047927644096 0.415275552801573 no 2020 0.370304141806649 3119 1068044 SGTC_2256 7954252 200 µM -0.331817864285767 0.414988264581063 no 2021 0.370013397040374 3056 2972920 SGTC_2268 7933382 153.85 µM -0.337817781522444 0.412751070487453 no 2022 0.36775025456575 2934 935025 YOR257W CDC31 SGTC_1753 st043925 64 µM -0.338407874647192 0.412531193717168 no 2023 0.367527920361437 3114 670181 SGTC_2963 9082507 9 µM -0.340394843006316 0.411791024311097 no 2024 0.366779600881848 3166 16459611 SGTC_2485 5633444 17.78 µM -0.340458783211577 0.41176721101884 no 2025 0.366755528514179 3084 5724239 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.340989085881662 0.411569722582124 no 2026 0.366555899048659 3005 641818 YHR062C RPP1 SGTC_2520 obtusaquinone 4.71 µM -0.341249663813857 0.411472689736093 no 2027 0.366457819170425 3164 5967872 SGTC_1715 st032160 10.2275 µM -0.34222610017803 0.411109136930503 no 2028 0.366090372342359 3114 5289825 SGTC_2681 menadione 3.18 µM -0.34282461143781 0.410886333241699 no 2029 0.3658652047495 3091 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2154 5570129 200 µM -0.343979060433716 0.410456655680553 no 2030 0.365431016820434 3051 673366 SGTC_2926 9010726 65.15 µM -0.346363561824768 0.409569502257608 no 2031 0.364534752865449 3132 2994293 SGTC_1011 4112-3381 17.4 µM -0.348315945161923 0.408843462695832 no 2032 0.363801460118274 3173 2877139 SGTC_1496 4469-0713 57.4 µM -0.348375224596244 0.408821423125613 no 2033 0.363779203229203 3126 746691 SGTC_2829 7992743 58.44 µM -0.348844113757439 0.408647104440571 no 2034 0.363603171630243 3171 16462845 SGTC_2101 5377231 179.231 µM -0.349357695791556 0.408456191046995 no 2035 0.363410394355093 3149 2844213 SGTC_2056 5235370 200 µM -0.350801426372857 0.40791963086902 no 2036 0.362868663519361 3031 5511916 SGTC_2618 avocadyne 43.43 µM -0.353845538333704 0.406788858422853 no 2037 0.361727321898722 2967 3015189 SGTC_2143 5623677 140.463 µM -0.354064675739023 0.406707487021849 no 2038 0.361645207095225 3078 5375313 SGTC_1183 1254-0324 198 µM -0.354173643136461 0.406667026100727 no 2039 0.361604377384998 3158 5799357 SGTC_2282 7944268 200 µM -0.355309743592181 0.40624523759545 no 2040 0.361178778375815 3225 2970414 SGTC_804 1595-0054 20.9 µM -0.355514066958107 0.406169392056419 no 2041 0.361102254214892 3036 761523 Stimulates phospholipase C. SGTC_1674 st016616 23.6 µM -0.355689926070324 0.406104115365974 no 2042 0.361036395072749 2985 625830 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.356196233004301 0.405916195181254 no 2043 0.360846806409734 3156 61125 An anti-inflammatory. SGTC_2402 5553605 200 µM -0.356997763085446 0.4056187447162 no 2044 0.360546740173922 3214 6758546 SGTC_1649 st011737 51.3 µM -0.35745168013915 0.40545031875199 no 2045 0.360376846772706 3090 1761035 SGTC_283 0987-0079 11.7 µM -0.357563197460239 0.405408942917303 no 2046 0.360335111960448 3139 411556 SGTC_1311 1190-0148 100 µM -0.357949335397651 0.405265683840824 no 2047 0.360190614584952 3162 1961333 SGTC_1861 st057647 17.4 µM -0.358916994070055 0.404906733502712 no 2048 0.359828593056853 3213 688668 SGTC_2077 5212015 200 µM -0.359788756032762 0.404583424273732 no 2049 0.359502556144539 2999 780900 SGTC_989 1501-0895 10.3 µM -0.360593288597362 0.404285106114647 no 2050 0.359201753585128 3161 2830112 SGTC_2081 5214970 32.255 µM -0.361313593403221 0.404018066550596 no 2051 0.35893251653505 3153 2063512 SGTC_2739 tacrine 100.86 µM -0.362440070880014 0.403600535753748 no 2052 0.358511599913401 3134 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2781 5567276 71.43 µM -0.362987331370617 0.403397732333337 no 2053 0.358307173975638 3197 2853274 SGTC_1973 st070275 50.2 µM -0.362999203815954 0.403393332938302 no 2054 0.358302739543317 3104 17118334 SGTC_1372 2752-0194 270 µM -0.36364862135273 0.403152706604114 no 2055 0.358060207174118 3034 823334 SGTC_2596 sinensetin 100 µM -0.363753274834777 0.403113933155694 no 2056 0.358021128496133 3077 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2379 9035213 200 µM -0.36771529012982 0.401646735710618 no 2057 0.356542769145178 3199 646551 SGTC_1467 k284-1082 293 µM -0.369151217921607 0.401115329677079 no 2058 0.356007507156615 3142 3334705 SGTC_1306 1185-0270 9.02 µM -0.369537923770633 0.40097224936577 no 2059 0.355863405632549 3154 1548076 SGTC_2808 7946468 45.46 µM -0.369604501268416 0.400947617178074 no 2060 0.355838598364533 3116 2970879 SGTC_569 4130-2812 160 µM -0.371100819573842 0.400394116867419 no 2061 0.355281220308035 3099 743552 SGTC_1016 4226-1401 38 µM -0.372460772126832 0.399891232791292 no 2062 0.354774906824104 3135 2901613 SGTC_715 0868-0130 184 µM -0.372613011785976 0.399834947833683 no 2063 0.354718243589424 3215 2876258 SGTC_358 0075-0058 9.45 µM -0.375088840220145 0.398919895176545 no 2064 0.353797198189206 3280 1069125 SGTC_1277 0873-0036 22 µM -0.376205391963907 0.398507405119264 no 2065 0.353382103583798 3175 5965735 SGTC_3077 9117319 49.47 µM -0.376806024598395 0.398285559006234 no 2066 0.353158881610964 3085 17154678 SGTC_380 3970-0968 6 µM -0.377086252715796 0.398182066849938 no 2067 0.353054753576274 3052 2891601 SGTC_2300 7976697 71.57 µM -0.37732881980794 0.398092489218906 no 2068 0.352964628626102 3031 2236109 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.377927862169278 0.397871291812277 no 2069 0.352742091891407 3109 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1915 st067105 30.6 µM -0.379357435948693 0.39734355203617 no 2070 0.352211226818758 3105 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1351 1496-0003 46.5 µM -0.379392378242249 0.397330655128408 no 2071 0.352198254772533 3209 3891978 SGTC_2259 7964009 200 µM -0.380363447570617 0.396972286529495 no 2072 0.351837821917778 3221 313134 SGTC_2946 9065502 71.43 µM -0.381576148878765 0.396524866948245 no 2073 0.35138788919925 3098 16489101 SGTC_3044 9093193 49.47 µM -0.382245733813602 0.396277885543923 no 2074 0.351139551009031 3163 25236277 SGTC_2617 dihydrotanshinone i 20.83 µM -0.384171232694259 0.395567883161943 no 2075 0.350425769192816 3063 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_57 miconazole 162.5 nM -0.384817844399643 0.395329531190717 no 2076 0.350186188712538 3139 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_179 1273-0063 6.77 µM -0.385057387161005 0.39524124162618 no 2077 0.350097449229003 3075 3108139 SGTC_2620 irigenin 100 µM -0.386148706046529 0.394839076472499 no 2078 0.349693269844575 3253 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2199 6590217 200 µM -0.38623584432389 0.394806969711838 no 2079 0.349661004766162 3112 703109 SGTC_819 1013-0258 27.7 µM -0.387311555121845 0.394410674800856 no 2080 0.349262786043861 3100 5753198 SGTC_1507 4075-3230 155 µM -0.387399107166345 0.394378425182164 no 2081 0.349230382337793 3150 659771 SGTC_1953 st076800 12.1 µM -0.389072384748034 0.393762216150044 no 2082 0.348611300498379 3104 297591 SGTC_194 1486-1323 56.904 µM -0.390486593316419 0.393241620368204 no 2083 0.348088383520655 3132 5178754 SGTC_3079 9117512 49.47 µM -0.391517474643094 0.392862254485984 no 2084 0.347707387280652 3140 7185044 SGTC_2439 5492030 7.2 µM -0.39245686170502 0.392516647219174 no 2085 0.347360339638959 3179 5722370 SGTC_1403 3909-7815 62.9 µM -0.392754593678793 0.392407127154391 no 2086 0.347250372069427 3058 6615483 SGTC_1495 4469-0029 237 µM -0.393333814763009 0.392194086347246 no 2087 0.347036473094355 3108 793680 SGTC_1936 st074407 74.3 µM -0.393474439627647 0.392142368594696 no 2088 0.34698454947019 3100 809813 SGTC_1357 1503-1303 39.5 µM -0.394425580760568 0.391792616500389 no 2089 0.346633430333736 3121 292895 SGTC_1070 indatraline 8.81 µM -0.394512613925657 0.391760617166369 no 2090 0.346601308120688 3119 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3270 9137563 49.47 µM -0.39458673337719 0.391733366372521 no 2091 0.346573952972471 3167 17015724 SGTC_3337 9144342 33.5465 µM -0.395190722214297 0.3915113233535 no 2092 0.346351069605527 3195 17682949 SGTC_3042 9091578 49.47 µM -0.396591239572123 0.390996590502708 no 2093 0.345834456860082 3203 25236497 SGTC_2851 9015922 71.43 µM -0.399245456949726 0.39002160901941 no 2094 0.344856175976343 3268 2996893 SGTC_2356 9061756 188.97 µM -0.399354641012686 0.389981516881932 no 2095 0.344815955496654 3164 20104043 SGTC_1810 st050138 53 µM -0.400868664949701 0.389425691579438 no 2096 0.344258410638326 3234 3444541 SGTC_1029 k015-0030 64.7 µM -0.401506856208936 0.389191467821431 no 2097 0.344023495658496 3218 2208316 SGTC_1006 4099-6547 255 µM -0.401686895499502 0.389125398544269 no 2098 0.343957234985859 3208 3146833 SGTC_3247 9135149 49.47 µM -0.402063270565607 0.388987290003114 no 2099 0.343818731453028 3131 8934436 YOR116C RPO31 SGTC_1449 4112-4002 201 µM -0.402652329862663 0.388771166437786 no 2100 0.343602003605475 3158 2059539 SGTC_2335 9018011 154.17 µM -0.403308279414569 0.388530541605704 no 2101 0.343360725852409 3186 6458208 SGTC_1108 betulinic acid 729.144 nM -0.405761829400023 0.387630875052198 no 2102 0.34245880372748 3166 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1645 Cervolide 78 µM -0.405997099134932 0.387544638063673 no 2103 0.342372365929294 3173 23173 A fragrance. SGTC_2194 5927483 104.545 µM -0.406844155297624 0.38723419967891 no 2104 0.342061226984897 3104 760979 SGTC_2537 larixol 68.93 µM -0.407405319180205 0.387028577910337 no 2105 0.34185516043617 3204 6708759 SGTC_771 0250-0039 27.3 µM -0.407426055326069 0.387020980375102 no 2106 0.341847546760579 3122 3005115 SGTC_2639 lactacystin 53 µM -0.407588464544277 0.386961476612167 no 2107 0.341787917311094 3267 3870 A proteasome inhibitor. SGTC_1392 3455-1037 33.9 µM -0.407832913722514 0.386871919919464 no 2108 0.341698173875019 3267 981132 SGTC_3090 9117696 49.47 µM -0.408209766005128 0.38673386766892 no 2109 0.341559839461192 3151 7923821 SGTC_815 1582-0027 36.9 µM -0.408307695524991 0.386697995505152 no 2110 0.341523895111314 3212 3128206 SGTC_941 3237-0776 460 µM -0.409659640229206 0.38620286919913 no 2111 0.341027820203272 3278 760008 SGTC_3177 9107506 49.47 µM -0.409660397702271 0.38620259183961 no 2112 0.341027542337329 3204 8897194 SGTC_1039 k821-0043 94 µM -0.410348812920692 0.385950542890803 no 2113 0.34077504473998 3248 15992768 SGTC_2027 5150920 200 µM -0.410391963080491 0.385934745957144 no 2114 0.340759220456965 3165 786715 SGTC_3226 9131256 49.47 µM -0.411094482335961 0.385677585814774 no 2115 0.340501627858036 3181 17178073 SGTC_1833 st055984 71 µM -0.411265711305758 0.385614914337639 no 2116 0.340438854635157 3144 676288 SGTC_45 0kpi-0036 14.9 µM -0.412487706468957 0.3851677389512 no 2117 0.339990994768837 3251 2795021 SGTC_2353 9059630 146.67 µM -0.412750451683187 0.385071610215207 no 2118 0.339894728401628 3220 4779114 SGTC_2361 9034121 116 µM -0.414705946138803 0.38435638952977 no 2119 0.339178589473122 3148 6496917 SGTC_2512 diallyl trisulfide 49.23 µM -0.416334074536682 0.383761202846058 no 2120 0.338582780948612 3201 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2229 7354935 190 µM -0.416530811180247 0.38368930135916 no 2121 0.33851081309977 3213 318112 SGTC_640 3381-0960 37.1 µM -0.416621055251247 0.38365632113126 no 2122 0.33847780306457 3213 1745025 SGTC_2473 5854593 8.94 µM -0.416719183168854 0.383620460661607 no 2123 0.338441910635581 3063 2872951 SGTC_1767 st044992 70.3 µM -0.416842615830612 0.383575354086181 no 2124 0.338396764527987 3182 9600693 SGTC_707 0865-0008 204 µM -0.418278487278796 0.383050752939908 no 2125 0.337871758253671 3128 723043 SGTC_2298 7976326 193.81 µM -0.419233333886308 0.382702014708013 no 2126 0.33752280642487 3154 2235818 SGTC_1961 st076550 68.7 µM -0.419748162714536 0.382514023423834 no 2127 0.337334718472199 3231 1579337 SGTC_962 1254-0300 21.5 µM -0.420106640583627 0.382383140505301 no 2128 0.337203775896032 3115 7340576 SGTC_3004 9076122 71.4286 µM -0.420229390486557 0.382338326696096 no 2129 0.337158943102886 3272 44782551 SGTC_20 0481-0013 4.944 µM -0.421339930447234 0.381932959974674 no 2130 0.336753438110016 3200 182045 SGTC_1422 4031-0024 15.5 µM -0.421420930538716 0.381903398567567 no 2131 0.336723868976902 3198 782427 SGTC_3010 9080089 71.4286 µM -0.423053071697678 0.381307887060429 no 2132 0.336128270133277 3232 17027233 SGTC_725 1497-0963 19 µM -0.424952464017737 0.380615218654859 no 2133 0.335435664024237 3251 3549977 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.42552870996165 0.380405149416582 no 2134 0.335225648546277 3369 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1414 3917-0015 5.4 µM -0.426330890150081 0.380112775054866 no 2135 0.334933376041082 3249 6618702 SGTC_261 5-fluorouridine 15.376 µM -0.426909751064224 0.379901837449792 no 2136 0.334722531468808 3348 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2099 5377090 177.372 µM -0.427870686296516 0.379551750414831 no 2137 0.334372635021323 3243 2243829 SGTC_996 3970-0799 1.8 µM -0.429576074833038 0.378930688070651 no 2138 0.333752021993696 3194 6615648 YGL040C HEM2 SGTC_3343 9148379 18.9835 µM -0.429619319554322 0.378914943416807 no 2139 0.333736290580549 3308 1955036 SGTC_1812 st052057 4.327 µM -0.430652204440994 0.378538947686744 no 2140 0.333360638247062 3129 3645418 SGTC_1509 1326-1131 80 µM -0.430770657714028 0.37849583509688 no 2141 0.333317568369327 3238 768313 SGTC_149 3970-0822 46.1 µM -0.431874344325552 0.378094206939815 no 2142 0.332916371121702 3291 3114250 YBL034C STU1 SGTC_759 3486-0358 89.3 µM -0.431949066375161 0.37806702057159 no 2143 0.332889216077207 3321 875103 SGTC_2151 5563267 85.4165 µM -0.432885749368084 0.377726275391957 no 2144 0.332548886690378 3192 5310824 SGTC_1126 isoteolin 1.0172 µM -0.434512679379734 0.377134659396727 no 2145 0.331958094718229 3137 133323 SGTC_450 aminopyrene 156 nM -0.435106573962751 0.376918767628441 no 2146 0.331742535949066 3264 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_683 panaxydol 45 µM -0.436338296084577 0.376471136363085 no 2147 0.331295650201535 3199 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1189 1431-2119 7.28 µM -0.438382477508164 0.375728608682886 no 2148 0.330554523217933 3264 3107275 SGTC_2255 7941087 197.44 µM -0.43850492910923 0.375684143985626 no 2149 0.330510148899679 3304 935561 SGTC_2513 baicalein 25.65 µM -0.439774089663133 0.375223382994018 no 2150 0.33005036773929 3212 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_970 1315-0089 19.5 µM -0.440448843624725 0.37497849010781 no 2151 0.329806027782033 3255 6811083 YLR033W RSC58 SGTC_1336 1486-0901 104 µM -0.44083173819344 0.374839546073932 no 2152 0.329667407390268 3232 5006114 SGTC_13 0199-0087 65 µM -0.442073923806786 0.374388896102854 no 2153 0.329217856612515 3230 4589825 SGTC_343 4130-2827 29.8 µM -0.442165436541584 0.374355703162742 no 2154 0.329184747627325 3214 1118244 SGTC_3172 9105863 49.47 µM -0.443666049246208 0.373811543092715 no 2155 0.328642022496427 3222 2348785 SGTC_2645 abamectin 100 µM -0.443695040051839 0.373801032766516 no 2156 0.328631540973493 3256 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2264 7948757 110.76 µM -0.443849200982773 0.373745144841588 no 2157 0.328575806900608 3111 2971411 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.444097128973866 0.373655269135167 no 2158 0.328486181055824 3201 6312947 SGTC_2970 9090938 41.86 µM -0.444856019389649 0.373380208540813 no 2159 0.328211903897387 3352 17217104 SGTC_1389 3405-0187 19 µM -0.446318759709155 0.372850218935046 no 2160 0.327683503554735 3219 799890 SGTC_2149 5554786 194.827 µM -0.446605349327651 0.372746408071331 no 2161 0.327580016288586 3202 745063 YPR165W RHO1 SGTC_1756 st041558 35.5 µM -0.449451133848115 0.371716087077058 no 2162 0.326553125763829 3357 3955792 SGTC_1426 4048-4480 71.7 µM -0.451722960243508 0.370894227236936 no 2163 0.325734287717747 3302 14224343 SGTC_2394 5221648 200 µM -0.451954699259984 0.37081042595169 no 2164 0.325650808800622 3307 788586 SGTC_2227 7312221 64.1025 µM -0.452966684467042 0.370444544492797 no 2165 0.325286365740267 3256 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1608 st001473 40.5 µM -0.452979791122247 0.370439806572686 no 2166 0.32528164677656 3205 7292267 SGTC_323 4013-0906 34.3 µM -0.453287587537285 0.370328547007997 no 2167 0.32517083478808 3269 2910086 SGTC_3055 9094636 49.47 µM -0.455006861173932 0.369707278718372 no 2168 0.32455215137388 3377 25236176 SGTC_2436 5633522 8.09 µM -0.455119043588034 0.369666752829196 no 2169 0.324511799147706 3349 5724242 SGTC_27 0485-0001 32.618 µM -0.457271256422538 0.368889546891821 no 2170 0.323738043499542 3260 2054479 SGTC_2909 7941780 10.49 µM -0.457378587137471 0.368850801683473 no 2171 0.32369947625667 3361 1243215 SGTC_1287 0971-0001 34.6 µM -0.460118675183512 0.36786211237463 no 2172 0.322715520041821 3275 4665869 SGTC_2158 5657123 3.6195 µM -0.460557246542619 0.367703946387452 no 2173 0.322558145516755 3282 2858827 SGTC_719 2810-4230 27.3 µM -0.460607841144641 0.367685701437702 no 2174 0.322539992473519 3262 721079 SGTC_2717 st081029 62.2815 µM -0.463205190124818 0.366749471842333 no 2175 0.321608648186928 3312 5292846 SGTC_1775 st081588 35.1725 µM -0.463264230028355 0.366728199751684 no 2176 0.32158749095431 3321 1426443 YGL099W LSG1 SGTC_2583 asiatic acid 100 µM -0.463408968993697 0.366676052001395 no 2177 0.321535625500177 3386 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_607 4491-0986 66.8 µM -0.463456087067536 0.366659076443345 no 2178 0.321518742059948 3331 698981 YDR232W HEM1 SGTC_1375 2910-0797 186 µM -0.46459348026222 0.366249379048721 no 2179 0.321111301043943 3228 742508 SGTC_1879 gemcitabine 100 µM -0.465382494010479 0.365965260000188 no 2180 0.320828784170449 3228 60750 A nucleoside analog which inhibits DNA replication. SGTC_1012 4112-3522 18 µM -0.465790081813115 0.365818518889163 no 2181 0.320682882552969 3356 3112398 SGTC_2533 agelasine 13.65 µM -0.46599105433786 0.365746171319336 no 2182 0.320610951888563 3419 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2031 5180455 200 µM -0.466188791085117 0.36567499324856 no 2183 0.320540185925017 3225 29949 SGTC_1930 st074634 34.3 µM -0.466697986834754 0.365491722504738 no 2184 0.320357985146024 3187 684253 YOR116C RPO31 SGTC_1796 st049173 110.4 µM -0.466740398836159 0.365476458877796 no 2185 0.320342811206697 3319 94134 SGTC_132 0417-1715 25.805 µM -0.467006586261139 0.365380665727967 no 2186 0.320247582950998 3382 6769098 SGTC_2529 gangaleoidin 93.61 µM -0.46765989071114 0.365145595972021 no 2187 0.320013914197672 3201 4565183 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.468148601263693 0.364969782945048 no 2188 0.31983916275015 3367 551469 SGTC_371 0195-0006 7.36 µM -0.469132455399151 0.364615928740142 no 2189 0.319487480836496 3215 3928593 SGTC_3105 9121040 49.47 µM -0.4699994255395 0.364304208746799 no 2190 0.319177713994423 3254 41448907 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.470740710822196 0.364037750025011 no 2191 0.318912954195299 3311 521171 SGTC_849 0386-0493 241 µM -0.470906552773036 0.363978146293671 no 2192 0.31885373419953 3223 726119 SGTC_3297 9117502 71.43 µM -0.471344423689028 0.363820790949187 no 2193 0.318697398439484 3313 7453720 SGTC_2848 9016370 25.97 µM -0.472354509087433 0.363457889551449 no 2194 0.318336884496266 3379 7894410 SGTC_402 epigallocatechin gallate 10 µM -0.473578254208941 0.363018389058821 no 2195 0.317900342742469 3231 65064 An antioxidant. SGTC_2763 lisinopril 49.32 µM -0.474895867647045 0.36254537796085 no 2196 0.317430598494432 3337 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.475130392248692 0.362461207753689 no 2197 0.317347018580967 3278 688788 SGTC_846 0335-0850 148 µM -0.475394156028229 0.362366551632037 no 2198 0.317253029531725 3290 6819598 SGTC_1867 st057372 64 µM -0.479501305242978 0.36089372007252 no 2199 0.315791019939206 3316 688837 SGTC_146 3448-8650 53.125 µM -0.479891649046395 0.360753848919067 no 2200 0.315652219806408 3253 2891488 YIL048W NEO1 SGTC_2046 4110841 106 µM -0.480513938503959 0.360530903638442 no 2201 0.315430997204474 3369 44119630 YMR134W ERG29 SGTC_1994 st072947 40.9 µM -0.481094820991247 0.360322835849779 no 2202 0.315224554377484 3349 5286565 YDL195W SEC31 SGTC_2279 7948423 32.93 µM -0.482331279620382 0.359880083346476 no 2203 0.314785315100433 3399 1247112 SGTC_2337 9009472 200 µM -0.48293849397524 0.359662720119247 no 2204 0.314569704262838 3431 5742383 SGTC_2556 citropten 84.59 µM -0.4830873725246 0.359609433308552 no 2205 0.314516849829831 3257 2775 A potential DNA crosslinker. SGTC_792 4534-1957 155 µM -0.483562612615659 0.359439353002854 no 2206 0.314348156902092 3246 1717904 SGTC_885 0865-0106 16.8 µM -0.483625649311997 0.359416795337501 no 2207 0.31432578408133 3234 2793380 SGTC_713 1488-1073 324 µM -0.483729993644543 0.359379456822037 no 2208 0.314288751960409 3325 3312542 SGTC_2858 9025781 8.96 µM -0.485013387375566 0.358920317876259 no 2209 0.313833424593651 3349 4894980 YPL153C RAD53 SGTC_2843 9000894 45.46 µM -0.485436422647444 0.358769020028832 no 2210 0.313683400573217 3263 2242070 SGTC_2396 5342950 42.78 µM -0.485927406029066 0.358593448438247 no 2211 0.313509318255199 3297 1886677 SGTC_34 0469-0683 81.75 µM -0.48809638378931 0.357818197980483 no 2212 0.312740786193701 3324 3690923 SGTC_2796 7949634 45.45 µM -0.488372163527049 0.357719668884949 no 2213 0.312643127605054 3267 2971588 SGTC_623 k072-0108 16.9 µM -0.489000942500206 0.357495057585824 no 2214 0.312420514795661 3318 5382803 SGTC_1706 st031321 9.9705 µM -0.489603865719231 0.357279728781039 no 2215 0.312207120226182 3355 6103185 SGTC_412 gemfibrozil 100 µM -0.490167446163556 0.35707849199366 no 2216 0.312007707324008 3345 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1803 st050068 52.4 µM -0.490363957728828 0.357008333261033 no 2217 0.311938188155373 3406 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2653 dihydrofissinolide 100 µM -0.490899211946746 0.356817260855062 no 2218 0.311748867230658 3361 6857746 SGTC_2893 9048488 25.97 µM -0.491806836686287 0.356493343570449 no 2219 0.311427951504208 3288 6467338 SGTC_1846 st056244 14.8 µM -0.492140763386593 0.356374196305295 no 2220 0.311309918549573 3293 5393182 SGTC_1512 0259-0544 12.2 µM -0.492639639583723 0.356196220081961 no 2221 0.311133617090279 3299 18476 SGTC_268 camptothecin 39.6153 µM -0.493925553725526 0.355737609204719 no 2222 0.310679378452696 3358 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1667 st014849 34.6 µM -0.494142682110219 0.355660192701997 no 2223 0.310602708075016 3323 5348460 SGTC_491 tetrandrine 80.3 µM -0.494240946835539 0.355625158652706 no 2224 0.310568012442765 3323 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1438 4092-1045 4 µM -0.495031405978682 0.355343382840313 no 2225 0.310288975846087 3272 1351342 SGTC_1840 st055363 71 µM -0.495631549240792 0.355129501923381 no 2226 0.310077194741437 3301 676033 SGTC_316 k060-0003 58.6 µM -0.498670098066507 0.354047316141778 no 2227 0.309005906650321 3378 6152314 SGTC_722 3534-0461 190 µM -0.501158633087709 0.35316189581288 no 2228 0.308129742413596 3330 658262 SGTC_1477 0139-0234 16 µM -0.502177471121057 0.352799622316147 no 2229 0.307771344417046 3346 620880 SGTC_306 1672-3436 11.6 µM -0.503081017867749 0.352478455156092 no 2230 0.307453655958992 3374 6797378 SGTC_1653 st012112 65 µM -0.50541576689035 0.351649052168149 no 2231 0.306633423525008 3401 720429 SGTC_229 benomyl 22.8748 µM -0.506327004366758 0.351325532764511 no 2232 0.306313554360406 3361 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1408 3909-7976 48.8 µM -0.506371414332311 0.351309768510108 no 2233 0.306297969022422 3335 24152374 SGTC_3126 9127922 49.47 µM -0.506717904413136 0.35118678332976 no 2234 0.306176383013032 3433 45595682 SGTC_220 paclitaxel 373.376 µM -0.508453900392596 0.350570833793009 no 2235 0.305567530396978 3362 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_663 1486-0733 13.9 µM -0.508537702468869 0.350541109861798 no 2236 0.305538152715276 3289 722445 YPR165W RHO1 SGTC_909 3448-9333 149 µM -0.50864030516976 0.350504718744343 no 2237 0.305502185985584 3283 3344074 SGTC_1387 3342-1166 1.8 µM -0.509944695409393 0.350042197418902 no 2238 0.305045103919658 3325 3418228 SGTC_1104 tacrolimus 29.8 µM -0.510128773330864 0.349976943458865 no 2239 0.30498062412686 3394 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1075 aripiprazole 15.2 µM -0.511228743811185 0.349587106251993 no 2240 0.304595446862722 3313 60795 An atypical antipschotic. YIL048W NEO1 SGTC_9 0092-0002 10.449 µM -0.511970999401719 0.349324135269361 no 2241 0.304335653155836 3390 759368 SGTC_1530 rhein 70.4 µM -0.515043151146386 0.348236484290087 no 2242 0.303261433357411 3384 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2722 naftopidil 47.16 µM -0.515461814820605 0.3480883588095 no 2243 0.303115173218209 3382 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2487 5918373 44.05 µM -0.518725137953853 0.346934573225152 no 2244 0.301976214599834 3471 2876279 SGTC_399 oxolinic acid 75 µM -0.518788992198744 0.346912010927768 no 2245 0.301953947503617 3304 4628 A DNA gyrase inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.519859604008273 0.346533801204999 no 2246 0.301580716284765 3460 688664 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.519865799515885 0.346531612993469 no 2247 0.301578557042617 3390 4213774 SGTC_373 0844-0104 25.9 µM -0.521031246303993 0.346120076204802 no 2248 0.301172502336516 3406 5375804 SGTC_2659 sanguinarine 24.21 µM -0.52167196926672 0.345893904645696 no 2249 0.300949372266969 3296 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3322 9139058 2.11 µM -0.521680665587326 0.345890835271988 no 2250 0.300946344309184 3429 4908926 YPR165W RHO1 SGTC_2407 paclitaxel 400 µM -0.522112551924685 0.34573841336835 no 2251 0.300795983789992 3443 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_58 0957-0393 9 µM -0.522217485785072 0.345701383744195 no 2252 0.300759456357127 3417 6997992 SGTC_3222 9128301 49.47 µM -0.522406723760275 0.345634608162915 no 2253 0.300693587757064 3290 4911358 SGTC_930 2810-3379 265 µM -0.522635154266762 0.345554009281342 no 2254 0.300614085975241 3480 1015764 SGTC_1220 1838-0075 193 µM -0.523647684682889 0.345196834774548 no 2255 0.300261804393995 3357 5529645 SGTC_595 3909-8003 73.7 µM -0.524630297723027 0.3448503455386 no 2256 0.299920110261567 3425 699517 SGTC_433 pimozide 108 µM -0.527864666157312 0.343710761889142 no 2257 0.29879663518863 3230 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3249 9135183 49.47 µM -0.528202897832362 0.343591672539679 no 2258 0.298679259158285 3447 4902779 SGTC_1239 0337-0584 35.4 µM -0.529166484199939 0.34325248467984 no 2259 0.298344982218342 3480 914301 YML130C ERO1 SGTC_408 cantharidin 100 µM -0.529831204207407 0.343018573026858 no 2260 0.298114484064941 3338 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2881 9058953 51.95 µM -0.530297195696271 0.342854628804307 no 2261 0.297952945355324 3301 17122249 SGTC_3239 9133757 49.47 µM -0.530298650464125 0.342854117037012 no 2262 0.297952441113915 3401 17036923 SGTC_1219 1469-0211 33.1 µM -0.530392120346693 0.342821236224085 no 2263 0.297920044055615 3388 6822282 SGTC_2740 felodipine 17.08 µM -0.531143599255017 0.342556924436154 no 2264 0.297659636654484 3370 3333 L-type calcium channel blocker SGTC_3098 9119039 49.47 µM -0.531716910182224 0.342355330097509 no 2265 0.297461039067963 3417 17161528 SGTC_1179 1021-1431 9.29 µM -0.532832630767907 0.341963136071898 no 2266 0.297074721805897 3376 2840958 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.533239224019398 0.341820254254333 no 2267 0.296933996315581 3378 442882 SGTC_1411 3909-8223 150 µM -0.533288258857765 0.341803024345758 no 2268 0.296917026989089 3426 X1411 SGTC_2007 4011539 71.82 µM -0.535008530564591 0.341198762420175 no 2269 0.296321979240949 3388 45595301 SGTC_583 1488-1091 88.9 µM -0.535287539192486 0.341100796282825 no 2270 0.296225520779867 3447 4303273 SGTC_2429 5902844 64.44 µM -0.535338555981806 0.341082884311038 no 2271 0.296207884886553 3396 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_892 0929-0076 29 µM -0.535692341837078 0.340958680111434 no 2272 0.296085598604926 3346 5751038 SGTC_2923 7992654 58.14 µM -0.536574832606413 0.340648937720683 no 2273 0.295780666190174 3370 2985126 SGTC_2471 5466956 24.79 µM -0.536605260462421 0.340638259867157 no 2274 0.295770154841153 3312 724419 SGTC_1571 st070080 73.4 µM -0.537750963023822 0.34023629877473 no 2275 0.295374495107045 3477 4315245 SGTC_1350 1495-0454 146 µM -0.539508953865775 0.339619873949736 no 2276 0.294767860206561 3467 1069057 SGTC_3234 9132280 49.47 µM -0.540549978924893 0.339255049198834 no 2277 0.294408901749605 3426 17612295 SGTC_2534 helenine 20.12 µM -0.540645017327072 0.339221750716162 no 2278 0.294376141375371 3397 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3065 9113888 49.47 µM -0.541315447298528 0.338986888713908 no 2279 0.294145087501705 3506 16648368 SGTC_1378 2093-0007 380 nM -0.542327523495337 0.338632461284992 no 2280 0.29379644908985 3404 3618014 SGTC_1663 st014140 55.4 µM -0.542417253171734 0.338601044989002 no 2281 0.293765548381189 3476 4207120 SGTC_67 0335-0847 266 µM -0.542428346791461 0.338597160951349 no 2282 0.293761728114005 3538 4552207 YOR254C SEC63 SGTC_1137 ixabepilone 100 µM -0.542465403296875 0.338584187054163 no 2283 0.293748967274322 3442 154225 A novel microtubule stabilizer. SGTC_2327 6189656 200 µM -0.54276777259178 0.338478331340422 no 2284 0.293644852469326 3426 5349088 SGTC_2317 5986382 200 µM -0.543502633179918 0.338221119036067 no 2285 0.293391889191352 3445 877883 SGTC_2918 7977171 22.06 µM -0.543725041011787 0.33814328781032 no 2286 0.293315348980071 3393 2236483 SGTC_2030 5175110 200 µM -0.544702784140237 0.337801210420839 no 2287 0.292978974846544 3464 2831986 SGTC_360 0957-0399 1.01 µM -0.545392233667106 0.337560077161979 no 2288 0.292741890362248 3442 6752301 YPR165W RHO1 SGTC_1960 st011366 51.8 µM -0.546363075433351 0.337220640738621 no 2289 0.292408193251401 3439 3972846 SGTC_1614 st002383 48.6 µM -0.547653606430004 0.33676963613477 no 2290 0.291964886756182 3458 1947235 SGTC_1984 st072354 53.1 µM -0.548778877609521 0.336376576682244 no 2291 0.291578603764495 3342 5762938 SGTC_3340 9146634 11.102 µM -0.549701138330649 0.336054562453895 no 2292 0.291262187983856 3433 4907387 SGTC_2370 9071495 200 µM -0.550069419525725 0.335926007913073 no 2293 0.291135880243078 3395 21791103 SGTC_851 0394-0702 453 µM -0.550441264896362 0.335796228710759 no 2294 0.291008376070586 3462 762646 SGTC_2863 9028737 58.44 µM -0.550718443393436 0.335699502299049 no 2295 0.290913349735075 3374 6460917 SGTC_1873 rapamycin 2 nM -0.552885919225432 0.334943498487887 no 2296 0.290170764940638 3418 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1609 st001574 46.4 µM -0.556341431276618 0.333739617620044 no 2297 0.288988734573465 3363 3960012 SGTC_2784 7567673 72.73 µM -0.558015717255787 0.333156919891878 no 2298 0.28841682580857 3493 3471247 SGTC_430 0958-0115 16.4 µM -0.558337471572333 0.333044986577477 no 2299 0.288306980930542 3351 6833180 SGTC_1709 st033179 39.1045 µM -0.558690260734728 0.332922273817597 no 2300 0.288186563631933 3415 573381 SGTC_3199 9111318 49.47 µM -0.56479564418145 0.330801445680847 no 2301 0.286106385052229 3409 8548020 SGTC_1992 st073643 23.3 µM -0.567062883161622 0.330015250702544 no 2302 0.285335729578471 3448 3161292 SGTC_608 k048-0125 159 µM -0.568626938430693 0.329473330927257 no 2303 0.284804669724019 3493 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2097 5376186 200 µM -0.569594641380886 0.329138216720817 no 2304 0.284476331888265 3457 742755 SGTC_1943 st076331 65.2 µM -0.570968443654755 0.328662706648526 no 2305 0.284010516938473 3519 24208415 SGTC_652 0437-0092 114 µM -0.573302662689017 0.327855406508699 no 2306 0.283219891424547 3478 3091274 SGTC_591 4299-0174 154 µM -0.574171040349327 0.32755527912362 no 2307 0.28292603209824 3394 5509088 SGTC_790 1575-0012 79.1 µM -0.574575548430548 0.327415511666791 no 2308 0.282789196411908 3512 378741 YLR208W SEC13 SGTC_1970 st070122 35.8 µM -0.575109182449324 0.327231165037961 no 2309 0.28260872906963 3550 102928 SGTC_2673 kobusone 100 µM -0.575353078158901 0.327146924031679 no 2310 0.282526265488695 3520 6710676 An epoxy ketone and protein crosslinker. SGTC_2241 6772625 37.8075 µM -0.576175456765553 0.326862941307789 no 2311 0.282248296353468 3463 2285411 SGTC_54 0159-0055 9 µM -0.576759757761387 0.326661232145882 no 2312 0.282050878955234 3580 3319099 SGTC_532 1548-0774 215 µM -0.576777334638178 0.326655165138159 no 2313 0.282044941297657 3596 5932993 SGTC_1187 1391-0724 117 µM -0.577133334462387 0.326532294604914 no 2314 0.28192469369514 3482 6997986 SGTC_483 fpl-64176 144 µM -0.578746347891516 0.325975811672906 no 2315 0.28138016885129 3494 3423 SGTC_3144 9087057 49.47 µM -0.579917914499677 0.32557186883833 no 2316 0.28098498714179 3455 17249618 SGTC_1072 oxiconazole 14.9 nM -0.58029341299585 0.325442444538247 no 2317 0.280858384340233 3502 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2223 6903751 107.57 µM -0.581326196892389 0.325086580108502 no 2318 0.280510313970937 3461 5598863 SGTC_2020 4017018 200 µM -0.581341214626394 0.325081406651523 no 2319 0.280505254212219 3479 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_818 4072-2707 53.5 µM -0.581437269782266 0.325048317422699 no 2320 0.280472892457752 3437 882871 SGTC_1790 st045711 43.5 µM -0.582449050935327 0.32469986134197 no 2321 0.280132125071695 3541 585119 SGTC_1857 st056007 79.3 µM -0.582864935189903 0.324556675816698 no 2322 0.279992113669491 3500 619834 SGTC_3062 9077494 49.47 µM -0.583566958725175 0.324315033725596 no 2323 0.279755847746656 3465 16459633 SGTC_477 mead ethanolamide 10 µM -0.583568389302128 0.324314541385106 no 2324 0.279755366384959 3394 16061185 SGTC_709 3807-1509 243 µM -0.584153436741765 0.32411322002578 no 2325 0.279558542840909 3517 1886677 YPL242C IQG1 SGTC_481 bay k-8644 50 µM -0.584336901874566 0.324050098212644 no 2326 0.279496834759933 3444 2303 A calcium channel antagonist. SGTC_1149 3909-7961 23.3 µM -0.584415867934084 0.324022931223901 no 2327 0.279470276741336 3465 735261 SGTC_1284 0929-0043 16 µM -0.584556513303715 0.323974546792642 no 2328 0.279422977652778 3432 1239883 SGTC_573 3702-0553 84.7 µM -0.585653370694806 0.323597311025479 no 2329 0.279054237578504 3491 1222756 SGTC_720 r052-1644 49.9 µM -0.586126327756852 0.323434705549698 no 2330 0.278895312544081 3488 1422863 YOR257W CDC31 SGTC_2708 st078559 56 µM -0.586168650655819 0.323420156326172 no 2331 0.278881093171324 3448 17250902 SGTC_760 0568-0725 82.9 µM -0.586607177262588 0.323269421167774 no 2332 0.278733780616115 3513 3916171 SGTC_2701 st077767 14.721 µM -0.587314662972194 0.323026297605767 no 2333 0.278496197547923 3477 5721188 SGTC_1458 k015-0034 6.33 µM -0.587711439245226 0.322889980705889 no 2334 0.278362998015505 3457 3598957 SGTC_1602 st001878 87.6 µM -0.591885575561885 0.321457354352363 no 2335 0.276963606765922 3535 595405 YLR310C CDC25 SGTC_1453 4237-0541 195 µM -0.592004409017781 0.32141660764711 no 2336 0.276923817983971 3489 739892 SGTC_368 fentichlor 4.58 µM -0.592954661107755 0.321090853828197 no 2337 0.276605747581433 3445 7329 A pesticide. SGTC_1193 1488-0126 41.5 µM -0.593448151523896 0.320921735750284 no 2338 0.276440636091135 3518 1384710 SGTC_661 1304-0007 33.6 µM -0.593656345826787 0.320850399161342 no 2339 0.27637099316571 3483 3117130 SGTC_1655 st012546 55.1 µM -0.59406039520198 0.320711972825161 no 2340 0.276235859464646 3477 720985 YLR208W SEC13 SGTC_3306 9127676 59.7925 µM -0.594359722525299 0.320609440082041 no 2341 0.276135770807088 3467 41905287 SGTC_2117 5521686 200 µM -0.598978806220183 0.31902894043832 no 2342 0.27459350885361 3490 803312 SGTC_2973 9094665 17.96 µM -0.600016831432088 0.318674213071238 no 2343 0.274247509131121 3556 25237061 YIL048W NEO1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.600826969709729 0.318397477547656 no 2344 0.27397761948262 3459 6708784 An antioxidant flavonoid SGTC_2882 9058044 58.44 µM -0.600888101634283 0.318376599572727 no 2345 0.27395725930727 3483 18076804 SGTC_1782 st039423 80.636 µM -0.600952544915474 0.318354591316987 no 2346 0.273935797084165 3431 2068169 SGTC_1713 st033146 12.748 µM -0.601256169154566 0.318250908142453 no 2347 0.273834689097401 3546 674619 SGTC_951 1171-0579 82.7 µM -0.602287256269042 0.317898913496783 no 2348 0.273491471096299 3522 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1679 SEC14.276 6.7 µM -0.603565481721447 0.317462778595551 no 2349 0.273066283978178 3500 1005053 YMR079W SEC14 SGTC_297 0986-0032 24 µM -0.605855047913333 0.316682204181194 no 2350 0.272305505883142 3477 2847425 SGTC_1628 st004252 77.7 µM -0.608187384366605 0.315887886679778 no 2351 0.271531600394064 3519 692968 SGTC_2920 7982904 15.77 µM -0.608421905356053 0.315808063440993 no 2352 0.271453843339103 3494 6456808 SGTC_2911 7942208 15.64 µM -0.608665178071314 0.315725270478582 no 2353 0.271373196311914 3504 1243384 SGTC_423 5-fluorouracil 457 µM -0.610364207956429 0.31514729789617 no 2354 0.270810286162976 3500 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_747 3448-8087 38.7 µM -0.61050316769121 0.315100046839147 no 2355 0.270764272837628 3499 5168703 SGTC_1574 spiramycin 23.7 µM -0.611281081589997 0.314835585428756 no 2356 0.270506756618473 3543 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1553 gossypol 38.6 µM -0.611341318908799 0.314815110968603 no 2357 0.270486821102788 3477 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_531 3788-1495 174 µM -0.612448763966522 0.314438795635382 no 2358 0.270120443480875 3508 2896655 SGTC_3236 9132701 49.47 µM -0.614217203115189 0.313838270939803 no 2359 0.269535903423802 3511 24282524 SGTC_974 1326-0144 138 µM -0.614486414153266 0.313746895721953 no 2360 0.269446974006354 3528 5411856 SGTC_807 1315-0151 48 µM -0.614642154500099 0.313694039776122 no 2361 0.269395534472728 3598 4011080 SGTC_2999 9069765 71.4286 µM -0.615235596314474 0.31349266954919 no 2362 0.269199571501603 3508 2097066 SGTC_1003 4049-0218 100 µM -0.615599612965831 0.313369176736767 no 2363 0.269079403393728 3582 295161 SGTC_638 3970-0837 4.09 µM -0.616245497778438 0.313150111523768 no 2364 0.268866252073279 3503 4118451 YLR208W SEC13 SGTC_1318 1280-3875 124 µM -0.617718049166946 0.312650911819367 no 2365 0.268380606070004 3535 373245 SGTC_3089 9117425 49.47 µM -0.618358076827011 0.312434047396649 no 2366 0.268169663202463 3499 9401657 SGTC_1836 st055642 81 µM -0.620082156244175 0.311850190460377 no 2367 0.267601849639924 3474 8571 SGTC_117 lucigenin 22.078 µM -0.62034636754867 0.311760757412926 no 2368 0.267514887071463 3548 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1064 honokiol 6.76 µM -0.621495188654208 0.311372021363359 no 2369 0.267136929593699 3523 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1022 4477-0945 21.3 µM -0.622644825619668 0.310983219679425 no 2370 0.266758973749142 3538 4648966 SGTC_3232 9132874 49.47 µM -0.623153659812759 0.3108112017045 no 2371 0.266591775213903 3504 3784940 SGTC_2017 5132927 60.65 µM -0.624049917618242 0.310508310724544 no 2372 0.2662974015424 3508 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3311 9131146 2.8755 µM -0.624248235224446 0.310441306491061 no 2373 0.266232286847733 3510 4900406 YPR165W RHO1 SGTC_2351 9026858 72.31 µM -0.624265245744789 0.310435559554014 no 2374 0.266226702066708 3486 1409300 SGTC_2502 avocadyne acetate 18.59 µM -0.624469352260099 0.310366606583908 no 2375 0.266159695796838 3542 3952079 SGTC_2181 6316240 54.2555 µM -0.62735312272935 0.309393100309596 no 2376 0.265213894288459 3538 12779990 SGTC_46 0329-0187a 2.197 µM -0.627358762106653 0.309391197869654 no 2377 0.265212046393041 3538 46494817 SGTC_859 0439-0102 54.6 µM -0.62746807861947 0.309354321030869 no 2378 0.26517622715487 3587 610143 SGTC_2484 5809818 12.04 µM -0.627777682626577 0.309249889617637 no 2379 0.26507479396958 3544 2870548 SGTC_1133 3473-0247 50 µM -0.628229420977902 0.309097543024316 no 2380 0.264926829766329 3488 711311 SGTC_535 2293-4129 48.2 µM -0.630065694897428 0.308478606568694 no 2381 0.264325801593048 3582 396118 YIL048W NEO1 SGTC_631 k072-0230 41.5 µM -0.632036169662835 0.307815041136843 no 2382 0.263681621380416 3572 5773147 SGTC_1911 st060208 74.3 µM -0.634028435564958 0.307144775869066 no 2383 0.263031132415471 3559 688783 SGTC_1786 berberine 21.6 µM -0.634564589809611 0.306964505402411 no 2384 0.262856214411361 3559 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_385 1494-0393 12.4 µM -0.63699098518043 0.306149265432004 no 2385 0.262065357803598 3561 3090647 SGTC_435 c-PAF 6.7 µM -0.637616095109804 0.305939391139748 no 2386 0.261861807925259 3517 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3112 9123419 49.47 µM -0.638740582598602 0.305562016307711 no 2387 0.261495853690186 3610 17015854 SGTC_1591 genipin 88.4 µM -0.638933543028053 0.305497280074772 no 2388 0.261433082876915 3572 442424 A DNA cross-linking agent. SGTC_2368 9071271 200 µM -0.639040791434578 0.305461301970004 no 2389 0.261398197879382 3547 27209959 SGTC_1795 st049545 62.3 µM -0.640878012938245 0.30484527013261 no 2390 0.260800971030556 3546 5291882 SGTC_1330 1469-0054 61.8 µM -0.642037489350018 0.304456774851946 no 2391 0.260424420886311 3581 7102664 SGTC_645 0845-0943 5.41 µM -0.642086705819913 0.304440289210183 no 2392 0.260408443603011 3551 1885106 SGTC_1264 0783-0040 158 µM -0.642649358022481 0.304251850406375 no 2393 0.260225824095452 3538 2855798 SGTC_944 3370-0224 231 µM -0.642913147524542 0.304163522107482 no 2394 0.260140228909725 3581 4580514 SGTC_2352 9027995 87.8 µM -0.643298860207996 0.304034389148738 no 2395 0.260015097864998 3529 2997347 SGTC_1503 4585-0012 61.3 µM -0.643593778934044 0.303935669637685 no 2396 0.259919442699839 3600 2922052 SGTC_1590 st077108 57.8 µM -0.64439796225016 0.30366655428901 no 2397 0.259658702799851 3571 5489485 SGTC_1904 st060225 78 µM -0.644947651449939 0.303482665163336 no 2398 0.259480555101422 3581 66595 SGTC_1093 fluphenazine 7.97 µM -0.647280211537501 0.302702901054817 no 2399 0.258725303136536 3638 6602611 An atypical antipsychotic. SGTC_3152 9099253 49.47 µM -0.648077566414996 0.30243655498015 no 2400 0.258467391424199 3611 25236131 SGTC_1043 0916-0009 19.3 µM -0.648795917263878 0.302196689206369 no 2401 0.258235148375402 3625 3101130 SGTC_3329 9141233 27.5565 µM -0.649038509292424 0.30211570417327 no 2402 0.258156742738183 3591 4909101 YNL103W MET4 SGTC_2252 omeprazole 400 µM -0.649178815874103 0.302068869764805 no 2403 0.25811140134664 3544 4594 A proton pump inhibitor. SGTC_1106 tegaserod maleate 11.7 µM -0.649407602794154 0.301992507567447 no 2404 0.258037475559023 3589 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3260 9137109 49.47 µM -0.65073251330648 0.301550462864493 no 2405 0.257609585589213 3494 17478346 SGTC_2333 9017922 200 µM -0.651430566167213 0.301317680838547 no 2406 0.257384292381101 3609 3163164 SGTC_3168 9103419 49.47 µM -0.65156011788206 0.301274487697655 no 2407 0.25734249145395 3553 16649256 SGTC_307 1501-1223 22.3 µM -0.652081486221518 0.301100689280546 no 2408 0.257174303343381 3595 2830329 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.652410782097545 0.30099094160836 no 2409 0.257068105306844 3575 2333 A French combination drug. SGTC_35 0133-0054 64.071 µM -0.653090115573611 0.300764590463186 no 2410 0.256849092103607 3542 99677 SGTC_1664 st014217 9.02 µM -0.65323835529331 0.300715207803036 no 2411 0.256801313381405 3649 3982782 SGTC_3299 9121982 43.1275 µM -0.653966642982119 0.300472648641297 no 2412 0.256566648258776 3586 17594604 YPL160W CDC60 SGTC_544 k015-0020 52.4 µM -0.654507693146628 0.300292506928339 no 2413 0.256392386187326 3594 3008304 SGTC_1439 4092-1168 46 µM -0.654919644498508 0.300155381182498 no 2414 0.256259745783872 3594 2886240 SGTC_2816 7982706 58.44 µM -0.656653196083547 0.299578646530192 no 2415 0.255701967800843 3593 2981853 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.657034606830769 0.29945182255629 no 2416 0.255579332320723 3570 689007 SGTC_1554 st069299 38.7 µM -0.657495332307302 0.299298657885283 no 2417 0.255431235654355 3599 24207999 SGTC_1292 0kpi-0043 232 µM -0.657709560591116 0.299227451432159 no 2418 0.255362388894016 3584 3333905 SGTC_1700 st030840 7.9285 µM -0.658326423925683 0.299022457727183 no 2419 0.25516420108367 3613 5499307 SGTC_2580 diallyl disulphide 81.36 µM -0.659625212493972 0.298591057811637 no 2420 0.254747185287752 3615 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3233 9132340 49.47 µM -0.659864784839873 0.298511513443514 no 2421 0.254670302257779 3558 17682950 SGTC_2826 7992541 19.48 µM -0.663393507342648 0.297341002530526 no 2422 0.25353928153463 3672 2985066 SGTC_205 1486-1330 71.903 µM -0.664077456567675 0.297114372867464 no 2423 0.25332036889524 3611 4118834 SGTC_2895 9054447 58.44 µM -0.665512179468782 0.296639227753187 no 2424 0.252861478058567 3645 2697450 SGTC_2934 9036370 36.88 µM -0.665826500141101 0.296535178930895 no 2425 0.252761002214232 3610 6462800 SGTC_3257 9139206 32.98 µM -0.667311894271834 0.296043698842931 no 2426 0.252286465214008 3581 4910041 SGTC_1987 st072290 61.9 µM -0.667921965619464 0.295841949731594 no 2427 0.252091702651346 3621 54697379 SGTC_795 0685-0265 78 µM -0.669067202594847 0.295463393295053 no 2428 0.251726305155018 3686 302754 SGTC_262 fenpropimorph 62.5 µM -0.669140816890825 0.295439067817808 no 2429 0.251702827464644 3584 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1874 staurosporine 7.6 µM -0.670438681436692 0.295010346325316 no 2430 0.251289091580251 3635 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1241 0364-0022 50.8 µM -0.670698572528425 0.294924531375744 no 2431 0.251206286204087 3623 4563895 SGTC_755 1995-0008 37.3 µM -0.672230585066393 0.294418901184223 no 2432 0.250718456388186 3632 689533 SGTC_1 0258-0098 57.368 µM -0.674952066817114 0.29352168314492 no 2433 0.249853109517366 3563 6790032 YDR047W HEM12 SGTC_98 0074-0023 107.663 µM -0.676218998952743 0.293104433381236 no 2434 0.249450805872025 3608 3563821 SGTC_1759 st043059 70 µM -0.678882157960817 0.292228250182447 no 2435 0.248606265781247 3634 669426 SGTC_594 1487-1584 10.8 µM -0.680367679281182 0.291740041497759 no 2436 0.248135840354102 3629 5013332 SGTC_379 3970-0972 5.9 µM -0.68122299220551 0.291459119983359 no 2437 0.247865200847552 3647 2898042 YBL034C STU1 SGTC_47 0149-0135 24.25 µM -0.68135369742145 0.291416201891429 no 2438 0.247823856773901 3605 5239155 SGTC_1054 3429-0080 167 µM -0.681739819146512 0.291289432991041 no 2439 0.247701742028197 3659 1162877 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.682045336197063 0.29118914592146 no 2440 0.247605142069855 3655 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1176 0848-0131 83.3 µM -0.682483317994164 0.291045404950305 no 2441 0.247466693834074 3707 6769040 SGTC_10 0279-0212 42.575 µM -0.682950437387034 0.290892137866751 no 2442 0.247319080657754 3669 39851 YBR002C RER2 SGTC_2383 9036125 200 µM -0.68313680564054 0.290830998893307 no 2443 0.247260200052989 3601 79580 SGTC_2576 guaiol 23.12 µM -0.683332746352297 0.290766726109026 no 2444 0.247198303238954 3652 227829 SGTC_4 0960-0234 25.671 µM -0.684856440533074 0.290267148302415 no 2445 0.246717257788962 3639 6821112 SGTC_186 3455-3465 67.277 µM -0.686550357933909 0.289712231330432 no 2446 0.24618306011748 3616 755278 SGTC_3067 9117431 49.47 µM -0.688185793353882 0.289176945534259 no 2447 0.245667894553691 3661 17150885 SGTC_3223 9129970 49.47 µM -0.688874499912553 0.288951667822508 no 2448 0.245451123908332 3698 17248386 SGTC_1670 st016595 4.04 µM -0.688912850182731 0.288939125776586 no 2449 0.245439056168147 3665 597879 SGTC_1849 st056239 19.2 µM -0.688964439072508 0.288922254585707 no 2450 0.245422823113502 3622 5393181 SGTC_2780 5215298 71.43 µM -0.691326572010585 0.288150259770188 no 2451 0.244680168403357 3658 2834131 SGTC_1941 st076221 61.8 µM -0.691590160215467 0.288064173986736 no 2452 0.244597371373902 3654 2828568 SGTC_362 0310-0100 9.03 µM -0.697976462274735 0.285982178217208 no 2453 0.242595957122503 3713 790235 SGTC_786 4544-0069 423 µM -0.698144536690137 0.285927481071307 no 2454 0.242543404023615 3702 748821 YLR208W SEC13 SGTC_2927 9011802 47.9 µM -0.699396002991733 0.285520367717634 no 2455 0.242152292528731 3659 43912568 SGTC_968 1309-0633 340 µM -0.702347942217173 0.284561169677614 no 2456 0.241231100864586 3657 3761976 SGTC_2123 5259487 200 µM -0.702966216956584 0.284360463633291 no 2457 0.241038401574031 3660 2173474 SGTC_2744 captopril 92.04 µM -0.705892149834532 0.283411558008897 no 2458 0.24012760489194 3652 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2177 5811945 192 µM -0.706307058130395 0.283277122608348 no 2459 0.239998602536966 3711 5343475 SGTC_309 k408-0051 1.48 µM -0.70652861082414 0.283205349333637 no 2460 0.239929733351418 3667 3640463 SGTC_3133 9127736 49.47 µM -0.706556747532558 0.283196234908779 no 2461 0.239920987886585 3681 27243420 SGTC_2777 climbazole 1.536 µM -0.707449742813724 0.282907036876049 no 2462 0.239643517017211 3654 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1096 rimcazole 32.2 µM -0.707897032909263 0.282762234547788 no 2463 0.239504601213888 3626 18528119 A dopamine reuptake inhibitor. SGTC_2551 apiole 73.87 µM -0.70809764520734 0.282697301400924 no 2464 0.239442310925438 3562 10659 A possible DNA adduct former. SGTC_2311 7694451 200 µM -0.708419749131341 0.28259305946612 no 2465 0.239342315892673 3661 2163142 SGTC_2254 7938975 95.19 µM -0.708847986519089 0.282454498361368 no 2466 0.239209407758405 3728 2969277 SGTC_2091 4-phenylthiadiazole 200 µM -0.709406096659438 0.282273964495825 no 2467 0.239036252748068 3700 270010 SGTC_2386 9075165 157.42 µM -0.71038895001861 0.281956172493444 no 2468 0.238731486789772 3670 16452277 SGTC_505 gw-5074 63.9 µM -0.710707259240074 0.281853288580144 no 2469 0.238632830157054 3721 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2966 9084041 48.03 µM -0.712892120493363 0.281147586341837 no 2470 0.237956257681293 3644 17741380 SGTC_674 0498-0004 451 µM -0.712907977190966 0.281142467807036 no 2471 0.237951351282645 3683 4231473 SGTC_3134 9127454 49.47 µM -0.714869960825428 0.280509487950199 no 2472 0.237344700106683 3777 24262820 SGTC_2840 9008771 71.43 µM -0.715516335460064 0.280301104173814 no 2473 0.237145025294502 3671 2992978 SGTC_621 3584-0052 32.1 µM -0.71608271104235 0.280118572827631 no 2474 0.236970139280593 3704 2273927 SGTC_1871 st057448 67.3 µM -0.719152778360209 0.279130156112089 no 2475 0.236023395563431 3780 691747 SGTC_2905 7799065 20.05 µM -0.720364433846816 0.278740527455045 no 2476 0.235650321080433 3639 1296806 SGTC_1924 st058459 75.1 µM -0.720837212990114 0.278588569029944 no 2477 0.23550483840055 3664 688683 SGTC_1800 st050079 29.0735 µM -0.723948303328033 0.277589624670228 no 2478 0.234548736822932 3660 3645560 SGTC_1376 2910-0861 41.3 µM -0.724279521181965 0.277483376634264 no 2479 0.234447073427279 3698 1112859 SGTC_1949 st076024 69.1 µM -0.72453868196088 0.277400256923808 no 2480 0.234367544101659 3694 2921930 SGTC_2244 6635614 200 µM -0.72499391502401 0.2772542811275 no 2481 0.23422788172937 3635 836499 SGTC_870 0573-2213 57.6 µM -0.726622885461 0.276732240721114 no 2482 0.233728502413996 3713 3916321 SGTC_263 alizarin 107.927 µM -0.726946910530094 0.276628457015412 no 2483 0.23362923928357 3739 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1968 st069590 43.6 µM -0.727134045021916 0.276568527408864 no 2484 0.233571922407372 3693 6384066 SGTC_465 cgp-37157 41 µM -0.727552848952132 0.2764344289946 no 2485 0.233443676434642 3646 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1845 st056753 3.01 µM -0.728384253741675 0.27616831286913 no 2486 0.233189199771474 3698 5375839 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.729652654274363 0.275762565506119 no 2487 0.232801264133296 3741 2374 Ca(2+)-ATPase inhibitor. SGTC_2972 9093619 59.92 µM -0.730628510436249 0.275450599402332 no 2488 0.232503046356655 3749 25236256 SGTC_2682 pyrogallin 40.03 µM -0.731467102681206 0.27518265322559 no 2489 0.232246945690974 3759 822798 An ATP competetive kinase inhibitor. SGTC_3153 9100258 49.47 µM -0.73240735722007 0.274882376705773 no 2490 0.231959984776486 3688 25236848 SGTC_1366 1683-0113 21.9 µM -0.73244555223673 0.274870182287938 no 2491 0.231948332025781 3740 708623 SGTC_2837 9008476 45.46 µM -0.734885770381132 0.274091653677624 no 2492 0.231204532593162 3725 2992805 SGTC_3219 9131112 49.47 µM -0.73510715126198 0.274021078131739 no 2493 0.231137119704371 3682 17612988 YMR079W SEC14 SGTC_484 loperamide 105 µM -0.735182819386771 0.273996957425116 no 2494 0.231114080451889 3709 3955 An opioid-receptor agonist. SGTC_2900 5328528 85.29 µM -0.735594436564254 0.273865764716903 no 2495 0.230988774672782 3751 795359 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.736670224880003 0.273523030752625 no 2496 0.230661459011815 3736 688669 SGTC_2823 7987624 58.44 µM -0.736783831722187 0.27348684929748 no 2497 0.230626908517947 3738 2239440 SGTC_888 0916-0002 6.97 µM -0.739107950539601 0.272747185412981 no 2498 0.229920724721803 3810 2802138 YIL048W NEO1 SGTC_417 st075190 100 µM -0.739208990328835 0.272715051459089 no 2499 0.229890051247973 3729 222757 SGTC_2912 7964298 10.93 µM -0.741174725207822 0.272090257600827 no 2500 0.229293753070665 3799 2975850 SGTC_1394 3474-0001 65.7 µM -0.741277690558063 0.27205755047391 no 2501 0.229262542843115 3720 5017666 YIL048W NEO1 SGTC_2412 st077135 33.4 µM -0.741805429948229 0.271889943810316 no 2502 0.229102615101007 3799 13258915 SGTC_1556 plumbagin 1.48 µM -0.74216891044367 0.271774534606079 no 2503 0.22899250127399 3664 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1632 st005650 90 µM -0.742994784302335 0.271512400894488 no 2504 0.228742419089349 3772 2759605 SGTC_2835 9006588 71.43 µM -0.743236624120577 0.271435664385428 no 2505 0.228669216807763 3774 2345538 SGTC_138 0850-0259 40.9225 µM -0.744271496932333 0.271107418188873 no 2506 0.228356120697003 3769 6813004 SGTC_2206 7254556 146.969 µM -0.745505353748123 0.270716316124929 no 2507 0.227983137928847 3750 4398905 SGTC_1750 st081859 2.357 µM -0.745570214839979 0.270695764560968 no 2508 0.227963540544462 3739 5291695 SGTC_2724 maprotiline 69.64 µM -0.745594326634663 0.270688124815901 no 2509 0.227956255553986 3703 4011 A tricyclic antidepressant. SGTC_649 1123-0311 367 µM -0.745918256687763 0.270585499054657 no 2510 0.227858398004105 3717 693629 YIL048W NEO1 SGTC_2569 tetrandrine 100 µM -0.746524265705929 0.270393558771546 no 2511 0.227675389386567 3772 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_109 0132-0036 33.701 µM -0.746730353512461 0.270328300414266 no 2512 0.22761317180513 3601 67274 A color developer. SGTC_42 0133-0086 60.653 µM -0.746899347770893 0.270274793722503 no 2513 0.227562159851188 3678 162923 Model of phenazepam hydroxylation. SGTC_1406 3909-7906 11.9 µM -0.747080125887042 0.270217561907122 no 2514 0.22750759799498 3762 X1406 SGTC_1618 st003135 44.5 µM -0.74746469797007 0.270095831943925 no 2515 0.227391552225387 3674 1270615 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.750468570197378 0.269145950660989 no 2516 0.226486273147031 3814 5024745 SGTC_3202 9113761 49.47 µM -0.752536082578409 0.268493139317533 no 2517 0.225864369649973 3816 4798415 SGTC_2106 5357045 167.29 µM -0.752608492343585 0.268470290569373 no 2518 0.225842606457782 3784 668842 SGTC_2564 betulinic acid 100 µM -0.753383421095862 0.268225824672706 no 2519 0.225609771214487 3760 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2147 5545932 89.7195 µM -0.753527989607382 0.268180230207766 no 2520 0.225566349170427 3779 797404 SGTC_478 N-arachidonylglycine 10 µM -0.753874410372733 0.268070990826197 no 2521 0.225462318804534 3699 5283389 SGTC_3283 9109332 35.8195 µM -0.755779425593872 0.267470669058422 no 2522 0.224890727152546 3640 17027281 SGTC_1570 verbenone 133 µM -0.7596389865896 0.266256498922521 no 2523 0.223735204184946 3770 29025 A natural terpanoid with antifungal properties. SGTC_1236 0330-0013 258 µM -0.759802388831807 0.266205156222971 no 2524 0.22368635739767 3781 4617066 SGTC_59 0330-0160 1.33 µM -0.761079276425738 0.265804117429456 no 2525 0.223304858814533 3744 4293482 SGTC_1310 1188-0297 994 nM -0.761806921861978 0.265575719059337 no 2526 0.223087624284749 3699 1588352 SGTC_2188 6126565 140.678 µM -0.762885999255133 0.265237194167485 no 2527 0.222765693337522 3720 874518 SGTC_1339 1486-1321 22.7 µM -0.763040076333647 0.265188875454068 no 2528 0.222719747734447 3815 3469382 SGTC_3248 9135562 49.47 µM -0.763053567439555 0.265184644843692 no 2529 0.222715724959751 3798 17650701 SGTC_1726 st035556 14.5795 µM -0.763152868287923 0.265153506627515 no 2530 0.222686116731014 3910 5919439 SGTC_2753 fluvastatin 17.09 µM -0.763375983041191 0.265083550298899 no 2531 0.222619599475066 3813 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2636 apigenin dimethyl ether 100 µM -0.764605843400135 0.264698103109217 no 2532 0.222253144268122 3779 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_558 k064-0027 21.3 µM -0.764882394138054 0.264611469362967 no 2533 0.222170789283327 3816 5088526 SGTC_714 4296-0578 26.1 µM -0.765103029685665 0.264542362250266 no 2534 0.222105097964993 3812 1589775 SGTC_2200 6600604 21.907 µM -0.76623335892786 0.264188466421087 no 2535 0.22176873131443 3737 2904777 SGTC_2305 7443522 69.23 µM -0.76718383688985 0.263891067140632 no 2536 0.221486110706505 3726 5415886 SGTC_2427 5545055 42.75 µM -0.768430147211657 0.26350136233515 no 2537 0.221115837779428 3763 5372858 SGTC_12 0849-0099 9.267 µM -0.77116674136278 0.262646697172403 no 2538 0.220304052449727 3703 6071388 SGTC_778 3456-2434 196 µM -0.771176490166743 0.262643655062836 no 2539 0.220301163614911 3821 5539063 SGTC_2441 5730946 39.09 µM -0.771946390186155 0.262403465081556 no 2540 0.220073089967828 3851 1774275 SGTC_1171 0368-0077 21.4 µM -0.772282653441834 0.262298594468765 no 2541 0.219973518525514 3758 3239779 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.772458074015034 0.26224389447675 no 2542 0.219921584724871 3822 23665772 A membrane-active detergent. SGTC_1661 st013063 9.66 µM -0.772782059096946 0.262142884169485 no 2543 0.219825686444268 3830 721395 SGTC_3145 9085516 49.47 µM -0.773512540049931 0.261915211964929 no 2544 0.219609555112288 3854 25236195 SGTC_2128 5255449 168.493 µM -0.777789023396588 0.260584379002868 no 2545 0.218346700000197 3804 736008 SGTC_2275 7947463 200 µM -0.77789693092855 0.260550843481608 no 2546 0.218314888868151 3744 1225414 SGTC_1884 5633444 25 µM -0.778133988968583 0.260477178346733 no 2547 0.218245013552857 3836 5724239 SGTC_1325 1431-0015 227 µM -0.779047922426746 0.260193276449929 no 2548 0.21797574282928 3758 1103340 SGTC_2421 5690543 90.72 µM -0.779933089755076 0.259918462496279 no 2549 0.217715130121216 3838 3397993 SGTC_168 3970-0862 530.542 µM -0.781073485102582 0.259564629859956 no 2550 0.217379637812234 3810 3135186 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.782779982133259 0.259035616706719 no 2551 0.216878162318834 3813 688751 SGTC_1676 st018489 23.4 µM -0.783314713761319 0.258869964996272 no 2552 0.216721162464291 3858 3696235 SGTC_2313 7726885 200 µM -0.783815638268324 0.258714835952139 no 2553 0.21657414819158 3823 726423 SGTC_1778 st046819 58.9 µM -0.784925566041955 0.258371278953855 no 2554 0.216248605682404 3857 671715 SGTC_547 1120-0019 610 nM -0.785067863716764 0.258327250521191 no 2555 0.216206890184581 3728 3676939 SGTC_1872 amphotericin b 148 nM -0.788287297896849 0.257332162980174 no 2556 0.215264337895654 3838 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_200 k038-0079 37.545 µM -0.78842437047273 0.2572898397886 no 2557 0.215224260216797 3773 3436683 SGTC_1050 3232-1156 69.3 µM -0.788677362562574 0.257211734229526 no 2558 0.215150301026837 3804 700529 SGTC_827 3253-0474 693 µM -0.788738398774854 0.257192892531755 no 2559 0.215132460034709 3796 5402065 SGTC_2586 curcumin 80 µM -0.790212514463107 0.256738055433183 no 2560 0.214701834346479 3835 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1163 k060-0048 49.9 µM -0.790542486615736 0.256636300204108 no 2561 0.214605509968464 3822 6809982 SGTC_1446 4239-0190 62 µM -0.790554995203961 0.256632443278886 no 2562 0.214601858997034 3820 1340085 SGTC_137 0438-0332 85.389 µM -0.791058300273651 0.256477278148005 no 2563 0.21445498568792 3818 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1755 st041960 45.185 µM -0.791194789242124 0.256435208061661 no 2564 0.214415165872793 3862 2257073 SGTC_2364 9055074 200 µM -0.791956975647514 0.256200344953202 no 2565 0.214192881744398 3828 6470630 SGTC_843 0310-0051 143 µM -0.793097632275915 0.255849068181234 no 2566 0.213860471112319 3854 2065037 SGTC_1468 k284-1086 134 µM -0.793964384707511 0.255582311162221 no 2567 0.213608082726542 3821 15996457 SGTC_1347 1493-0251 600 nM -0.794082075254069 0.255546101206644 no 2568 0.213573825973491 3860 3986378 SGTC_1226 3909-7979 35.4 µM -0.798011880892833 0.254338554820914 no 2569 0.212431797773652 3852 6615510 SGTC_2076 5212012 200 µM -0.801275086589206 0.253338118284108 no 2570 0.211486205202956 3729 604802 SGTC_666 0272-0154 136 µM -0.80635597820693 0.251784541666556 no 2571 0.21001881105013 3875 6870312 SGTC_178 4092-0806 87.505 µM -0.809078898252902 0.250954033446372 no 2572 0.209234882595633 3788 2169044 SGTC_563 tetrahydrosecaminediol 614 µM -0.809509954127086 0.25082269166367 no 2573 0.209110939760765 3912 334274 A psychoactive constituent of the cannabis plant. SGTC_3218 9131285 49.47 µM -0.812478128728923 0.249919284297311 no 2574 0.208258665732788 3817 17156417 SGTC_142 0335-0849 62.6745 µM -0.813564935796898 0.249588931128253 no 2575 0.207947116048648 3875 3889043 YPR107C YTH1 SGTC_1257 0669-0121 16 µM -0.814437940900648 0.24932373474739 no 2576 0.207697055348919 3872 4307855 SGTC_2372 9071633 200 µM -0.817167395842438 0.248495564184764 no 2577 0.206916386087433 3917 21321366 SGTC_266 formosanin C 406 nM -0.818930910406475 0.247961259539107 no 2578 0.206412916542448 3791 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2737 bleomycin 30.5 nM -0.821079097927804 0.247311236927997 no 2579 0.205800607545158 3882 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2225 6654152 15.4 µM -0.821982224971657 0.247038230888213 no 2580 0.205543506706493 3758 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2388 9080168 200 µM -0.822290919751729 0.246944952610671 no 2581 0.205455671692333 3838 15943073 SGTC_1474 0330-0125 5.35 µM -0.824534721847364 0.246267509878522 no 2582 0.204817897600505 3861 X1474 SGTC_108 0509-0257 621.132 µM -0.82596109549973 0.245837381524273 no 2583 0.204413080654673 3844 536624 SGTC_2991 9074669 71.4286 µM -0.82654458121914 0.245661545492865 no 2584 0.204247619812564 3838 17333109 SGTC_1300 1094-0077 113 µM -0.828031345921089 0.245213807773891 no 2585 0.203826374039401 3826 5532636 SGTC_832 4083-0019 164 µM -0.828441894058531 0.245090248961016 no 2586 0.20371014453733 3942 1990758 SGTC_946 3434-1334 87.4 µM -0.830723898244484 0.244404066406602 no 2587 0.203064811272443 3865 4047976 SGTC_2036 5160441 105 µM -0.830737006365921 0.244400127879524 no 2588 0.20306110792576 3857 134534 YIL048W NEO1 SGTC_292 k038-0015 474 µM -0.831905274931015 0.244049241877764 no 2589 0.202731207092968 3856 46368540 SGTC_2683 piperine 63.03 µM -0.83237366399693 0.24390863895673 no 2590 0.202599031312933 3845 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1820 st053765 18.6 µM -0.834555352620635 0.243254307190625 no 2591 0.201984054652297 3916 3690829 SGTC_3174 9107204 49.47 µM -0.835166701091412 0.243071121980558 no 2592 0.20181192773083 3918 3938802 SGTC_24 0417-1663 219 µM -0.835446463117238 0.242987318630268 no 2593 0.201733189229138 3842 4329390 SGTC_1651 st011928 86.1 µM -0.837578601765796 0.242349145413435 no 2594 0.201133707428292 3892 720198 SGTC_353 1988-1175 58.3 µM -0.838518576761062 0.242068088985446 no 2595 0.200869759455496 3740 2788357 SGTC_490 phenamil 164 µM -0.839077441283141 0.241901069993434 no 2596 0.200712927090017 3853 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1280 0880-0253 10.1 µM -0.839296945211895 0.241835487433222 no 2597 0.200651348513603 3868 6836607 SGTC_3295 9122362 53.5725 µM -0.839319773478793 0.241828667443195 no 2598 0.200644945032595 3946 4730473 SGTC_1065 prochlorperazine maleate 2.48 µM -0.840415935367233 0.241501309756666 no 2599 0.200337608725569 3923 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_221 trifluoperazine 10.304 µM -0.841527486054905 0.24116960227189 no 2600 0.200026246770557 3858 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3282 9108498 15.4605 µM -0.841558275811405 0.241160417559925 no 2601 0.200017626242778 3897 16459645 SGTC_3081 9117243 49.47 µM -0.841903659836869 0.241057401104541 no 2602 0.199920940798219 3920 45595589 SGTC_2699 st077704 54.6 µM -0.843255986618151 0.240654277797222 no 2603 0.199542646297402 3902 645852 SGTC_2603 homopterocarpin 100 µM -0.843709520374337 0.240519163380698 no 2604 0.19941587310691 3938 101795 A weak amylase inhibitor. SGTC_641 4092-0595 30 µM -0.844949657875204 0.240149919062288 no 2605 0.199069473597266 3922 786260 SGTC_1041 0206-0046 107 µM -0.848120312152478 0.239207280094146 no 2606 0.198185485277285 3934 50494 SGTC_3287 9117173 37.0625 µM -0.849271239434159 0.238865608980662 no 2607 0.197865190285726 3873 2789709 SGTC_1184 1269-1718 139 µM -0.849548406908721 0.238783367293581 no 2608 0.19778810326933 3977 5403821 SGTC_798 1287-0182 476 µM -0.851124274964245 0.238316067106305 no 2609 0.197350161025806 3890 1649755 SGTC_2608 thymoquinone 42.66 µM -0.85182425095001 0.238108660427608 no 2610 0.197155822176891 3896 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2694 st077685 81.9 µM -0.852667965596857 0.237858794736182 no 2611 0.196921730203827 3882 2838096 SGTC_2330 7979373 200 µM -0.853264606506242 0.23768218664302 no 2612 0.196756291433129 3864 1863007 SGTC_2180 6301957 200 µM -0.853388105347779 0.237645639481393 no 2613 0.196722057741054 3880 845462 SGTC_278 4092-0821 23.9 µM -0.854197541540009 0.237406178399293 no 2614 0.196497772573182 3927 877900 SGTC_3324 9138759 60.749 µM -0.855942435925617 0.236890425172422 no 2615 0.19601481036886 3957 45595710 SGTC_925 2064-1272 59.6 µM -0.856264067163398 0.236795425182649 no 2616 0.195925866032315 3894 6815817 SGTC_93 0109-0045 59.227 µM -0.861358673247858 0.235293432571718 no 2617 0.194520264922127 3993 88733 SGTC_1567 st069303 68.4 µM -0.861833984594984 0.23515356995026 no 2618 0.194389440333957 4003 5581319 SGTC_3000 9075062 71.4286 µM -0.865205553378569 0.234162788940612 no 2619 0.19346298894212 3887 17057871 SGTC_2078 5212016 200 µM -0.866164401858032 0.233881441096723 no 2620 0.193200005971158 3793 1899708 SGTC_2052 5265182 7.135 µM -0.866356884008707 0.233824985060607 no 2621 0.193147240282613 3941 1239884 SGTC_1689 st020265 53.493 µM -0.866925942492403 0.233658121364922 no 2622 0.192991294093525 3906 5758320 YPR016C TIF6 SGTC_2409 alverine citrate 63.97 µM -0.870643442830325 0.232569673340676 no 2623 0.19197443414748 4124 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1069 diphenylcyclopropenone 8.49 µM -0.870777265695909 0.232530543940287 no 2624 0.191937890395287 3971 65057 A dermal irritant. YDR527W RBA50 SGTC_524 r073-0010 27.8 µM -0.873537691182572 0.231724220926638 no 2625 0.191185035756888 3857 2772106 SGTC_512 prima-1 270 µM -0.873619354756282 0.231700390665608 no 2626 0.191162791145443 3948 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3182 9108849 49.47 µM -0.873879510998456 0.231624483534579 no 2627 0.19109193690521 3981 17133045 SGTC_1751 st044839 27.194 µM -0.873964822551797 0.231599594759815 no 2628 0.191068705584963 3882 5291326 SGTC_336 4111-0029 111 µM -0.874110843543722 0.231556998085456 no 2629 0.191028946403626 3938 3131175 SGTC_472 calcifediol 10 µM -0.875356575165487 0.231193775720221 no 2630 0.190689959930339 3961 5283731 A vitamin D metabolite. SGTC_2419 paclitaxel 166.5 µM -0.876438039875493 0.230878707185285 no 2631 0.190395973084866 3868 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2152 5568786 200 µM -0.87757704040676 0.230547135841037 no 2632 0.19008664676486 3894 5399883 SGTC_431 k089-0097 107 µM -0.877810858689806 0.230479102574445 no 2633 0.190023185331215 3814 5499420 SGTC_3290 9121031 71.43 µM -0.878073795527517 0.230402610193493 no 2634 0.189951836287306 3953 17014854 SGTC_2286 7945697 125 µM -0.878407330649153 0.230305600106977 no 2635 0.189861353793402 3967 1245733 SGTC_375 3970-0961 9.27 µM -0.879409458251348 0.230014264554703 no 2636 0.189589652820996 3902 2898222 SGTC_2572 astragaloside iv 100 µM -0.88047440683524 0.229704892043652 no 2637 0.189301181881061 4022 45006101 An anti-inflammatory agent. SGTC_2841 9004761 38.96 µM -0.880506004516276 0.229695716331834 no 2638 0.189292626899957 3957 2991039 SGTC_1957 st077035 62.4 µM -0.880922601516953 0.229574759118891 no 2639 0.189179856718799 3958 705593 SGTC_2778 tioconazole 65.09 nM -0.881691568486473 0.229351586500107 no 2640 0.188971810889556 3856 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1985 st071382 65.5 µM -0.882479588747888 0.229123010385958 no 2641 0.188758756436959 3940 6123237 SGTC_1903 st060211 78.3 µM -0.884760461065669 0.228462132663917 no 2642 0.188142919331506 3997 688960 SGTC_3135 9127742 49.47 µM -0.885847509148942 0.228147540110375 no 2643 0.187849852404101 4028 3643468 SGTC_1789 tunicamycin 25 nM -0.886517632474077 0.227953727326215 no 2644 0.187669328454961 3881 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3302 9125395 16.351 µM -0.887293001621571 0.227729591018536 no 2645 0.187460586217747 3897 17599668 SGTC_980 1473-0395 201 µM -0.88734087488108 0.22771575634101 no 2646 0.187447702647385 3843 768876 SGTC_222 nsc-310342 10.666 µM -0.8881659997757 0.227477381574969 no 2647 0.187225732447006 3905 432556 SGTC_2216 7189485 200 µM -0.891570852523911 0.226495223304039 no 2648 0.186311499476405 3959 731273 SGTC_3016 9080866 49.47 µM -0.892550232488086 0.226213156992158 no 2649 0.186049040409387 3953 17066299 SGTC_2950 9072895 21.46 µM -0.893267778259342 0.226006626269752 no 2650 0.185856894514093 3920 17332245 SGTC_2148 5546263 113.568 µM -0.894182149513414 0.22574359793004 no 2651 0.185612220693425 3937 792097 SGTC_1798 st045719 60.953 µM -0.894699978231842 0.225594715982635 no 2652 0.185473745169927 3849 3980186 SGTC_813 k007-0158 173 µM -0.894797150614001 0.2255667839541 no 2653 0.185447766897653 3969 6523916 SGTC_3049 9092223 49.47 µM -0.897561063768271 0.22477312202424 no 2654 0.184709802433316 3954 8623917 SGTC_2752 diclazuril 33.15 µM -0.898207844828373 0.224587626736988 no 2655 0.184537375932819 3949 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_15 0266-0086 27.098 µM -0.899413930594618 0.224241956243931 no 2656 0.184216110896665 4037 1712902 YIL048W NEO1 SGTC_908 3448-7491 47.7 µM -0.900517536118247 0.22392592197032 no 2657 0.183922448691729 3982 1203031 SGTC_1259 0671-0132 43 µM -0.901045796608688 0.223774736136392 no 2658 0.18378198526112 3896 X1259 SGTC_1122 capsaicin 818.572 nM -0.901161087415713 0.223741748128807 no 2659 0.183751338546903 4057 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_324 1315-0088 19.6 µM -0.902837256890836 0.223262460333413 no 2660 0.18330613722598 3934 6787421 SGTC_2462 5162487 171.77 µM -0.903316162975859 0.223125628224831 no 2661 0.183179060352473 3863 2259986 SGTC_669 0108-0021 26.2 µM -0.904016021794628 0.222925751833259 no 2662 0.182993452915951 3909 17201 SGTC_2621 lithochol-11-enic acid 100 µM -0.904460073701623 0.222798985599831 no 2663 0.182875748126549 3896 6708711 SGTC_918 glabranin 770.725 nM -0.905258706097267 0.222571098492493 no 2664 0.182664173672829 3998 124049 Also referred to as licorice root. SGTC_842 0271-0008 11.1 µM -0.906409586237901 0.222242932521197 no 2665 0.182359550359508 4033 1221709 SGTC_2444 5485484 36.41 µM -0.906594441687245 0.222190247941135 no 2666 0.182310651079107 4063 6790631 SGTC_2168 5727979 200 µM -0.906613006090721 0.222184957401973 no 2667 0.182305740743623 3872 695210 SGTC_3085 9117376 49.47 µM -0.907483522625799 0.221936955735191 no 2668 0.182075579542423 4064 16480349 SGTC_1309 pyrazolanthrone 13.4 µM -0.909234022035961 0.22143873435995 no 2669 0.18161330451183 3976 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2126 5251174 33.877 µM -0.909816492144443 0.221273095531843 no 2670 0.181459647759172 3998 790722 SGTC_16 erodoxin 22.806 µM -0.909986162214683 0.221224859260042 no 2671 0.181414903773288 3986 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2326 6164455 177.58 µM -0.910073038773551 0.221200163058759 no 2672 0.181391996080647 3987 2888790 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.913035248212623 0.220359046718725 no 2673 0.18061200176836 4025 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_693 4161-2696 114 µM -0.913887594694185 0.220117363915153 no 2674 0.18038795637277 4020 805759 SGTC_1721 st082152 9.2685 µM -0.916374012690607 0.21941320952354 no 2675 0.179735380358692 3934 5296051 SGTC_963 1269-2853 151 µM -0.916379538164369 0.21941164615022 no 2676 0.179733931817085 3969 3668223 SGTC_1784 st039334 36.3 µM -0.916986777382066 0.219239873356636 no 2677 0.179574784504069 4073 3496984 SGTC_965 1291-5240 308 µM -0.918834940432696 0.218717550136709 no 2678 0.17909095685269 4013 2834598 SGTC_564 3555-0129 330 µM -0.920807375111968 0.218160896447262 no 2679 0.178575501908664 3852 563260 SGTC_2174 5790901 200 µM -0.921426798115798 0.217986253640017 no 2680 0.178413821511999 4019 786020 SGTC_1741 st038134 10.228 µM -0.923631812618 0.217365216870792 no 2681 0.177839022381321 4076 1272587 SGTC_612 0302-0167 22.4 µM -0.92444649865285 0.21713602132297 no 2682 0.177626947359648 4014 235821 SGTC_2136 5328288 199.296 µM -0.925347810225511 0.216882618175592 no 2683 0.177392508437462 4000 262395 SGTC_2678 equilin 100 µM -0.925653197418065 0.216796797561189 no 2684 0.177313118920589 4010 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_884 0851-0618 334 µM -0.925867035340002 0.216736716024466 no 2685 0.177257542227522 4026 9642473 SGTC_745 0469-0705 296 µM -0.926054020344467 0.216684187180647 no 2686 0.177208953651566 4090 3486736 SGTC_1694 st024011 44.9 µM -0.927175837483749 0.216369194854249 no 2687 0.176917622982614 4029 2787533 SGTC_2605 digitonin 300 nM -0.930371118009565 0.215473453660668 no 2688 0.176089483592029 4059 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2389 9091542 195.52 µM -0.931917511425927 0.215040722765324 no 2689 0.175689578496963 3992 3626624 YOL127W RPL25 SGTC_2746 daunorubicin 9.88 µM -0.933346449158276 0.21464130871319 no 2690 0.175320559969361 3921 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1900 st060200 72.8 µM -0.934111757261387 0.214427568620832 no 2691 0.175123123877496 3986 688945 SGTC_2121 5257820 149.641 µM -0.936113932081556 0.213868974365413 no 2692 0.174607265271516 4065 791256 SGTC_3310 9130229 44.1445 µM -0.937317373137782 0.213533629930192 no 2693 0.174297664500666 4087 7761258 SGTC_3320 9137005 35.139 µM -0.937354679261093 0.213523239304694 no 2694 0.1742880725955 4026 4908713 SGTC_162 k030-0015 37.8 µM -0.937917424946529 0.213366537253391 no 2695 0.174143423815834 4087 1809920 YMR134W ERG29 SGTC_2435 5706476 10.6 µM -0.938423073160342 0.213225791753385 no 2696 0.174013516537123 4016 5725375 SGTC_1188 1403-0014 4.57 µM -0.940390122355828 0.212678785377754 no 2697 0.173508743499205 4022 9614867 SGTC_1708 st033234 31.827 µM -0.942555359068604 0.212077614509453 no 2698 0.172954191291864 4115 674664 SGTC_2140 5586273 200 µM -0.942917926271811 0.211977046128668 no 2699 0.172861442458536 3992 854421 SGTC_2861 9024595 19.48 µM -0.943440563949133 0.211832126719158 no 2700 0.17272780155643 3920 16482810 SGTC_710 3448-4187 58 µM -0.945414637006337 0.211285269780153 no 2701 0.172223616219734 4002 3946412 SGTC_2523 spermine 47.74 µM -0.946371117436737 0.21102060366578 no 2702 0.171979665771351 4039 1103 A DNA binding polyamine. SGTC_206 4546-0025 72.014 µM -0.949304834681794 0.210210032816966 no 2703 0.171232797670173 4087 6620745 YIL048W NEO1 SGTC_991 3996-0057 64.7 µM -0.950180031715994 0.209968575015435 no 2704 0.171010391531953 4089 715343 SGTC_2354 9060492 162 µM -0.952770625668517 0.20925481286732 no 2705 0.170353150220838 4105 6471895 SGTC_1757 st041620 31.8375 µM -0.953854957000065 0.20895648170294 no 2706 0.170078533161706 4110 5289815 SGTC_55 0767-0285 6.563 µM -0.954260418675194 0.208844991761824 no 2707 0.16997591911952 3951 3116166 SGTC_1090 efavirenz 20.7 µM -0.95634391249489 0.208272645749404 no 2708 0.169449255621061 4063 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2675 theaflavin digallate 100 µM -0.95728295498736 0.208014988977425 no 2709 0.16921222810847 3991 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2619 obliquin 87.91 µM -0.95828795862786 0.20773944219005 no 2710 0.16895878701692 3978 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1015 4130-4525 82 µM -0.958409223049699 0.207706209111056 no 2711 0.168928223136855 4033 1363237 SGTC_2014 4013930 200 µM -0.958907363309061 0.207569724409217 no 2712 0.168802707507553 3967 64556 SGTC_2813 7971799 71.43 µM -0.95931071585496 0.207459249291278 no 2713 0.168701119308779 4090 2234054 SGTC_148 3253-0744 288.01 µM -0.961550713273614 0.206846364192294 no 2714 0.168137669722406 3946 6893655 SGTC_1578 josamycin 24.2 µM -0.962643756003471 0.206547686560331 no 2715 0.167863165539211 4053 5282165 A P450 substrate. SGTC_1322 1348-1070 12 µM -0.963714078378181 0.206255465039323 no 2716 0.167594647038121 4039 6758089 SGTC_2952 9073731 13.78 µM -0.965087292419379 0.205880906551615 no 2717 0.167250545629305 4126 16457353 SGTC_18 0111-0177 500 nM -0.967684163130619 0.205173686994757 no 2718 0.166601064885901 4096 721752 SGTC_750 4073-0104 132 µM -0.972480833500609 0.203871186414991 no 2719 0.165405697722602 3832 22330957 SGTC_1155 4088-0394 48.2 µM -0.973056548651435 0.203715187114975 no 2720 0.165262598964006 4036 2326248 SGTC_2476 5806916 10.51 µM -0.973211936631392 0.203673094436667 no 2721 0.165223989731748 3921 2870194 SGTC_615 k087-0205 167 µM -0.973231565523984 0.203667777581837 no 2722 0.165219112958551 4056 9642773 SGTC_3197 9113331 49.47 µM -0.974957115479594 0.203200703399007 no 2723 0.164790766366729 4086 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3170 9103054 49.47 µM -0.975076236051602 0.203168483291985 no 2724 0.16476122271474 4057 16432970 SGTC_507 nimesulide 162 µM -0.975661598632669 0.203010196900307 no 2725 0.164616094055286 4123 4495 A COX2 inhibitor. SGTC_2788 5282734 71.43 µM -0.975814061991537 0.202968981766444 no 2726 0.164578307490615 4156 743706 SGTC_331 k048-0133 24.5 µM -0.977394313964499 0.202542089606951 no 2727 0.164186988452372 4019 6813582 SGTC_3272 9137413 49.47 µM -0.97916109117377 0.20206544523257 no 2728 0.163750195098101 3996 17614870 SGTC_619 1652-1634 108 µM -0.979804292109527 0.201892088119633 no 2729 0.163591366524492 4034 5400454 SGTC_936 3005-4620 401 µM -0.979970212563674 0.201847383277979 no 2730 0.163550411256983 4115 777207 SGTC_3271 9137798 49.47 µM -0.979970588286627 0.201847282051646 no 2731 0.163550318522303 4002 6498326 SGTC_3091 9116372 49.47 µM -0.980068480750854 0.201820909145855 no 2732 0.163526158195607 4145 17169793 SGTC_1147 3809-1045 12.3 µM -0.982609946177311 0.201136943172168 no 2733 0.162899723667848 4034 325925 SGTC_2992 9074591 71.4286 µM -0.982708837865596 0.201110357303938 no 2734 0.162875379874593 4023 17741321 SGTC_1546 5-methoxyflavanone 78.7 µM -0.985863165377478 0.200263459570814 no 2735 0.162100132175771 4058 147795 SGTC_521 r062-0005 13.8 µM -0.987453419894073 0.199837309753547 no 2736 0.161710203622141 3989 2832033 SGTC_1545 lovastatin 49.4 µM -0.988424224841318 0.199577425788011 no 2737 0.161472464136177 4143 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.99165212774402 0.198714781486462 no 2738 0.1606836256348 4109 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2063 5246145 200 µM -0.992160006093796 0.198579257998296 no 2739 0.16055973928719 4108 711240 SGTC_480 am 92016 50 µM -0.994816472005396 0.197871309042957 no 2740 0.159912766692462 4057 2129 K+ channel blocker. SGTC_1896 st058441 89 µM -0.99928060711511 0.196685055249849 no 2741 0.158829388562108 4092 688759 SGTC_1270 0831-1170 17.3 µM -1.00001820648831 0.196489468602822 no 2742 0.158650848534393 4086 6764716 SGTC_3162 9099653 49.47 µM -1.00046454247615 0.196371172507822 no 2743 0.158542874360539 4076 25237511 SGTC_1717 st033143 58.0435 µM -1.0016788047813 0.196049565130152 no 2744 0.158249373305428 4167 674616 SGTC_1748 st037455 53.6035 µM -1.00479097302623 0.195226741728125 no 2745 0.157498755734677 4150 580690 SGTC_1444 4112-3581 28 µM -1.00518380207247 0.195123031372047 no 2746 0.157404176668605 4119 2877249 SGTC_2898 9056270 58.44 µM -1.0062914208212 0.194830790560554 no 2747 0.157137703085242 4050 19154699 SGTC_2745 rifampicin 24.3 µM -1.00730885329596 0.194562579754117 no 2748 0.156893188304352 4117 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_957 1187-1561 14.1 µM -1.00737816562422 0.194544316140124 no 2749 0.156876539909921 4061 1538454 SGTC_2649 anisomycin 9.56 µM -1.00774978765474 0.194446412519099 no 2750 0.15678729841027 4105 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2600 tangeritin 87.95 µM -1.00823360458045 0.194318996163795 no 2751 0.15667116444245 4032 68077 A bioactive flavone. SGTC_1225 1216-0074 20.6 µM -1.00841997388655 0.194269928153258 no 2752 0.15662644402195 4122 4241466 SGTC_2582 agaric acid 100 µM -1.00850294760039 0.194248084949991 no 2753 0.156606536690772 3835 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_8 0354-0001 70 µM -1.01087620661941 0.193623947205109 no 2754 0.156037841638995 4093 4993152 SGTC_3181 9108277 49.47 µM -1.01216565451782 0.19328535169934 no 2755 0.155729427467614 4044 17097298 SGTC_2819 7996655 46.38 µM -1.01309650149316 0.193041145770288 no 2756 0.155507034594727 4055 6456960 SGTC_1933 st074711 15.9 µM -1.01487285982362 0.192575644652638 no 2757 0.155083218479762 4079 17250958 SGTC_2814 7977482 42.97 µM -1.01489401182138 0.192570105832029 no 2758 0.155078176485803 4169 6456762 SGTC_327 1273-0057 3.96 µM -1.0161748946651 0.19223487787344 no 2759 0.154773054638282 3975 3108138 SGTC_2185 6113692 200 µM -1.01860722816383 0.191599279766352 no 2760 0.154194735676988 4124 874150 SGTC_703 3875-0075 71.8 µM -1.02113587477819 0.190939880362714 no 2761 0.153595034201651 4151 2850814 SGTC_3064 1327-0027 10 µM -1.02346530637396 0.190333664088864 no 2762 0.153043947695807 4020 16000455 YPR107C YTH1 SGTC_1888 azatryptophan 97.5 µM -1.02529575750106 0.189858134005652 no 2763 0.15261182849863 4157 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3060 1327-0027 12.5 µM -1.02867464173731 0.188982259743208 no 2764 0.151816294950671 4022 16000455 YPR107C YTH1 SGTC_1159 4092-0538 61.2 µM -1.03135714008501 0.188288678165824 no 2765 0.151186685960707 4154 717301 SGTC_2092 5303694 80.6725 µM -1.03250970963643 0.187991154978607 no 2766 0.150916700719566 4117 1963699 SGTC_948 3448-0295 75.3 µM -1.03283757641867 0.18790657281737 no 2767 0.150839957778068 4114 678569 SGTC_255 tunicamycin 200.472 nM -1.03308382673157 0.187843061300465 no 2768 0.150782335681669 4051 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2980 9014342 25.29 µM -1.0340352592096 0.187597797684398 no 2769 0.150559840037324 4192 2996599 SGTC_1129 3453-1384 223 µM -1.03404631222447 0.187594949562451 no 2770 0.150557256538732 4223 1084452 SGTC_2359 9039622 200 µM -1.03439615107831 0.187504817491225 no 2771 0.150475501510118 4069 6463596 SGTC_2955 9076254 12.21 µM -1.0361057945418 0.187064732031258 no 2772 0.150076394604828 4052 16459619 SGTC_2809 7964133 12.99 µM -1.03648597325611 0.186966955771405 no 2773 0.149987739968472 4146 1253665 SGTC_2801 7907800 81.82 µM -1.03982237954405 0.18611023908204 no 2774 0.149211214841845 4150 6620925 SGTC_2237 6667747 47.222 µM -1.0406572366379 0.185896247116666 no 2775 0.149017328406056 4137 729940 YDL015C TSC13 SGTC_3154 9100113 49.47 µM -1.04327897068054 0.185225232373755 no 2776 0.148409553889057 4149 25237525 SGTC_80 0159-0065 512.242 µM -1.04345401182301 0.185180485430809 no 2777 0.148369034698795 4015 1548079 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.04463728692806 0.184878172992139 no 2778 0.148095319759128 4139 1377 SGTC_2460 5552655 174.22 µM -1.0480470231769 0.184008743432816 no 2779 0.147308471216476 4162 5401989 SGTC_1983 st071813 46.9 µM -1.0490676017764 0.183749007628275 no 2780 0.147073503000881 4198 11838595 SGTC_3020 9089140 49.47 µM -1.04975382822254 0.183574492454446 no 2781 0.146915654184898 4179 17217859 SGTC_695 3505-6186 243 µM -1.05061731893274 0.183355043783358 no 2782 0.146717191769378 4154 1819379 SGTC_1716 st033144 30.6155 µM -1.05162160113816 0.183100020010363 no 2783 0.146486596578355 4160 674617 SGTC_1209 2323-2347 50.3 µM -1.05326801643754 0.18268241429607 no 2784 0.146109086563089 4153 5412760 SGTC_2873 9040596 71.43 µM -1.05469599569728 0.18232069586961 no 2785 0.145782191876239 4141 6463863 SGTC_2292 7671323 168.05 µM -1.05538526687832 0.182146258292034 no 2786 0.145624579156654 4222 937504 SGTC_1194 1488-0194 225 µM -1.05565451400905 0.182078146812319 no 2787 0.145563042686665 4091 1391452 SGTC_3224 9130643 49.47 µM -1.05669165179085 0.181815930767365 no 2788 0.14532616811996 4206 17644395 SGTC_503 tyrphostin 8 294 µM -1.0577432855897 0.181550291063035 no 2789 0.14508624769231 4158 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2798 7813637 45.45 µM -1.05894317593808 0.181247499030001 no 2790 0.144812829699834 4154 956368 SGTC_1123 mangostin 811.285 nM -1.05968102415727 0.181061460346207 no 2791 0.144644869248107 4159 5281650 An antioxidant. SGTC_2131 toluylene red 5.2905 µM -1.063396454761 0.18012648260623 no 2792 0.143801099917734 4132 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1887 st057648 70.8 µM -1.06569546200148 0.179549464584029 no 2793 0.143280664854647 4164 688672 SGTC_2415 st077333 57.7 µM -1.0660643167012 0.179456995582315 no 2794 0.143197284368985 4219 2766255 SGTC_1139 k015-0024 46.9 µM -1.06696029110011 0.179232506481665 no 2795 0.142994883736138 4182 2766652 SGTC_1625 st003711 30.1 µM -1.06757557787342 0.17907844685061 no 2796 0.142856002451037 4238 24207034 YER133W GLC7 SGTC_1442 4112-3290 3 µM -1.06770194921475 0.179046815461811 no 2797 0.14282748945661 4139 704353 SGTC_2879 9041815 71.43 µM -1.06786755939559 0.179005367714513 no 2798 0.142790128880088 4169 4942971 SGTC_2742 clothiapine 36.27 µM -1.06805990935087 0.178957235304022 no 2799 0.142746744277688 4152 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2153 5569715 200 µM -1.06808656564612 0.178950565647463 no 2800 0.142740732643706 4191 2054701 SGTC_1472 k841-0093 193 µM -1.06812437357578 0.178941106015048 no 2801 0.14273220634221 4266 X1472 SGTC_1760 st045453 10.4495 µM -1.06862906756841 0.178814860537198 no 2802 0.142618422633962 4210 3323419 YIL048W NEO1 SGTC_2525 harmine 47.85 µM -1.07221900476357 0.177918482696018 no 2803 0.141810838109854 4150 5280953 A monoamine oxidase inhibitor SGTC_1814 st052110 31.539 µM -1.07232548536393 0.177891938710112 no 2804 0.141786931848752 4121 674163 SGTC_1208 2323-2347 50.3 µM -1.07566961187701 0.177059570334877 no 2805 0.141037521288827 4183 5412760 SGTC_1688 st021091 57.6 µM -1.0757708052922 0.177034421246994 no 2806 0.141014886044598 4191 3656366 SGTC_1658 st012944 20 µM -1.07606943176203 0.176960218278484 no 2807 0.140948102751611 4025 24207260 SGTC_2267 7931562 200 µM -1.07740664633893 0.176628187115034 no 2808 0.140649318086055 4108 934880 SGTC_897 1000-0139 31.4 µM -1.07908050500716 0.176213122613463 no 2809 0.140275920524224 4137 6151020 SGTC_2492 derrusnin 100 µM -1.0792671572517 0.176166876991582 no 2810 0.140234324665232 4163 1715307 Part of coumarin class of compounds. SGTC_1749 st037932 54.2 µM -1.07943445860737 0.176125432343804 no 2811 0.140197048314578 4205 594497 SGTC_860 0443-0016 25.1 µM -1.08141596700286 0.175635033656007 no 2812 0.139756061126302 4196 5337942 SGTC_643 k048-0106 28.4 µM -1.08195708332751 0.175501264637804 no 2813 0.139635799105018 4183 6763920 SGTC_2465 5809242 33.21 µM -1.08456718004942 0.174856931610267 no 2814 0.139056698828986 4226 2731748 SGTC_2765 myclobutanil 7.74 µM -1.08500739336139 0.174748407931608 no 2815 0.138959190368457 4222 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_110 0850-0284 111.64 µM -1.08543661959435 0.17464263402397 no 2816 0.13886416040982 3979 3906265 SGTC_1905 st060207 84.5 µM -1.08614671994148 0.174467733791868 no 2817 0.138707042586716 4149 1948547 SGTC_1980 st071811 45.7 µM -1.08731063394372 0.174181298370119 no 2818 0.138449775289164 4265 4974850 SGTC_1548 st061468 90.8 µM -1.08886561802051 0.173799088546291 no 2819 0.13810657500866 4177 390799 SGTC_293 4049-0273 38.5 µM -1.09030118159364 0.173446705824799 no 2820 0.137790247443504 4049 1380311 SGTC_2685 mycophenolic acid 18.85 µM -1.09425910332547 0.1724775260322 no 2821 0.136920678180281 4166 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1273 0849-0096 14.1 µM -1.09507403689807 0.172278402140706 no 2822 0.136742101047138 4205 5286025 SGTC_511 blebbistatin 171 µM -1.09648290952091 0.171934499112464 no 2823 0.136433749241415 4241 3476986 A myosin inhibitor. SGTC_1476 4112-3294 3.34 µM -1.09719626482696 0.17176053775943 no 2824 0.1362778028111 4192 704369 SGTC_3166 9102297 49.47 µM -1.10023200622715 0.171021488838273 no 2825 0.135615524334085 4185 25237072 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.10068016706279 0.17091255699325 no 2826 0.135517940499998 4182 756377 SGTC_570 0987-0065 62.6 µM -1.10149491020763 0.170714635860223 no 2827 0.135340659243237 3975 3104428 SGTC_1493 4348-0038 111 µM -1.10163431862973 0.170680784832763 no 2828 0.135310341076947 4165 800424 SGTC_554 4483-2211 187 µM -1.10494305820483 0.169878621052245 no 2829 0.134592131652709 4257 747107 SGTC_259 usnic acid 108.925 µM -1.10667457514623 0.169459800811874 no 2830 0.134217325834729 4277 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1261 0712-0010 12.7 µM -1.10927161251838 0.16883287135323 no 2831 0.133656513716397 4222 2840123 SGTC_357 1325-0123 420 µM -1.11419876273445 0.167647549856149 no 2832 0.132596963055741 4219 1098503 SGTC_466 geldanamycin 89.2 µM -1.11585673467254 0.167249900700995 no 2833 0.132241731990811 4148 5288382 HSP90 inhibitor. SGTC_2065 5221596 34.26 µM -1.11618585286628 0.167171037141533 no 2834 0.132171294430956 4195 788581 SGTC_2792 7535235 81.82 µM -1.12119945917418 0.165972637879067 no 2835 0.131101484948392 4211 1281891 SGTC_3160 9100216 49.47 µM -1.12585320139047 0.164865237641686 no 2836 0.130113830440029 4185 17191039 SGTC_3349 9149703 23.001 µM -1.12666359074379 0.164672888475904 no 2837 0.129942370903172 4228 4910494 SGTC_2073 5212005 126 µM -1.12730528734125 0.164520682406122 no 2838 0.129806713839454 4059 691789 SGTC_1962 st076595 64.5 µM -1.12939457293224 0.164025750001068 no 2839 0.129365710610157 4200 279619 SGTC_1490 4089-0339 670 nM -1.13268278937904 0.163248760518234 no 2840 0.128673743845303 4193 742542 SGTC_1035 k081-0041 55.2 µM -1.1333094212293 0.163100962212936 no 2841 0.128542168376843 4252 731709 SGTC_3037 9091026 49.47 µM -1.1339570034647 0.16294831392782 no 2842 0.12840629204713 4149 25236398 YIL048W NEO1 SGTC_754 3474-0146 171 µM -1.13415115474009 0.162902566632958 no 2843 0.128365574474251 4207 24762078 SGTC_705 1124-0212 310 µM -1.13649668161355 0.162350556944624 no 2844 0.127874376786931 4224 9554485 SGTC_1100 amiodarone 5.07 µM -1.13663939506414 0.162317009286917 no 2845 0.127844532101185 4318 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2514 salinomycin 42.74 µM -1.13685084671147 0.162267311634846 no 2846 0.127800321567164 4284 23682228 A polyether potassium ionophore. SGTC_2743 auranofin 4.32 µM -1.1369195364418 0.162251169563753 no 2847 0.127785962132418 4222 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2545 solidagenone 89.61 µM -1.13973667529516 0.161590043289644 no 2848 0.127198011383422 4085 6708572 An anti ulcer agent SGTC_1360 1598-0022 39.8 µM -1.14007789234527 0.161510085859623 no 2849 0.127126925700883 4264 761525 SGTC_2318 6029776 164 µM -1.140384048289 0.161438366262619 no 2850 0.127063167824512 4288 818325 SGTC_207 4185-0010 4.486 µM -1.14478038909254 0.160410777272212 no 2851 0.126150070486828 4302 3761753 SGTC_1119 parthenolide 318.541 nM -1.14701709768306 0.159889618916723 no 2852 0.125687277309972 4323 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3123 9126162 49.47 µM -1.14717975923111 0.159851761641599 no 2853 0.125653667576401 4291 25239884 SGTC_1412 3909-8563 178 µM -1.14838736873995 0.159570890228662 no 2854 0.125404342891327 4313 23767530 SGTC_560 2332-1943 155 µM -1.15332152620319 0.158426639162927 no 2855 0.124389218916406 4210 21177716 SGTC_987 1497-1013 404 µM -1.15334574842012 0.15842103524196 no 2856 0.124384249797737 4260 1676435 SGTC_3025 9087895 49.47 µM -1.1556993055134 0.157877149155291 no 2857 0.123902086171278 4225 17173641 SGTC_678 1218-2179 85.9 µM -1.15574434003254 0.157866754048927 no 2858 0.123892872906319 4260 6820081 YOR116C RPO31 SGTC_1053 3366-3204 134 µM -1.15608235019072 0.157788747100241 no 2859 0.123823737320629 4267 3632071 YPR165W RHO1 SGTC_2431 5490079 200 µM -1.15822910911277 0.157293903045294 no 2860 0.123385276111094 4300 5722345 SGTC_550 4123-0385 25.7 µM -1.15859334089046 0.157210046230931 no 2861 0.123310992258389 4277 5731123 SGTC_290 2043-6722 48.1 µM -1.15939892861622 0.15702468078756 no 2862 0.123146806647587 4266 773758 YLR208W SEC13 SGTC_2145 5634607 200 µM -1.15973417872828 0.156947582239192 no 2863 0.123078524999921 4217 308662 SGTC_1067 clotrimazole 1.36 µM -1.16001991752873 0.156881889628609 no 2864 0.123020348459208 4282 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_347 4534-1311 26.2 µM -1.16014499668672 0.15685313907233 no 2865 0.122994888356833 4263 2862016 SGTC_1290 0986-0249 10.2 µM -1.16114853519552 0.15662259232746 no 2866 0.122790749881196 4102 53329 SGTC_523 1934-0222 13.7 µM -1.1624209733812 0.156330591128653 no 2867 0.122532254001918 4195 1361595 SGTC_2067 5224629 34.075 µM -1.16350293020099 0.156082584162337 no 2868 0.122312754978328 4255 2835000 SGTC_365 0121-0052 13.6 µM -1.16396812235468 0.155976032209067 no 2869 0.122218465289774 4268 3101739 SGTC_1441 4106-0040 13 µM -1.16537639547379 0.155653760516443 no 2870 0.121933333853047 4258 2904180 SGTC_677 0929-0063 136 µM -1.16880689337203 0.154870558484674 no 2871 0.12124072121395 4258 1539583 SGTC_107 0358-0022 2.6945 µM -1.1688951834387 0.154850435783777 no 2872 0.121222932171092 4284 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2677 mitomycin C 100 µM -1.16925543814265 0.15476834594783 no 2873 0.121150365610349 4304 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1494 4358-1428 177 µM -1.17078586237718 0.154419934697042 no 2874 0.120842430957249 4287 1564571 SGTC_1824 st053723 68.6 µM -1.17101423889478 0.154367987762021 no 2875 0.120796526892801 4281 675225 SGTC_1338 1486-1223 76 µM -1.17591376598785 0.153256315568643 no 2876 0.119814668662891 4276 3444526 SGTC_801 0866-0028 10.1 µM -1.17725044413532 0.152953954920225 no 2877 0.119547779996625 4283 6849771 SGTC_1711 st032263 62.8 µM -1.18053093632464 0.152213575101478 no 2878 0.118894556873874 4275 3958979 SGTC_1128 3448-9350 235 µM -1.18156950455209 0.151979675616956 no 2879 0.118688279856045 4309 619386 SGTC_3173 9105693 49.47 µM -1.18458247828979 0.151302465180025 no 2880 0.118091284078849 4279 17096658 SGTC_1317 1273-0028 910 nM -1.18677781139169 0.150810297445423 no 2881 0.117657636612625 4286 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_213 1246-0773 967 nM -1.18696536314826 0.150768300031491 no 2882 0.117620641558648 4289 6251622 SGTC_3316 9136639 10.545 µM -1.18711898028979 0.150733907207151 no 2883 0.117590346327221 4275 4903665 SGTC_3209 9113616 49.47 µM -1.18837666971596 0.150452523831468 no 2884 0.117342521891819 4327 16649353 SGTC_3150 9097574 49.47 µM -1.18890848383327 0.15033364617649 no 2885 0.117237840653335 4318 17217476 SGTC_2179 6298986 200 µM -1.19203789856592 0.149635388814914 no 2886 0.116623192677297 4259 738374 SGTC_2522 biochanin a 4.94 µM -1.19448614811984 0.149090628981372 no 2887 0.116143927991438 4295 5280373 A possible chelator. SGTC_1052 3253-3998 198 µM -1.19853615932596 0.148192372881182 no 2888 0.115354177376489 4220 5450317 SGTC_887 0885-0007 9.62 µM -1.20042830505774 0.147773955559711 no 2889 0.114986520724599 4337 5719458 SGTC_256 clotrimazole 625 nM -1.20135797603725 0.147568664017067 no 2890 0.114806185035536 4224 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3265 9137266 49.47 µM -1.20433198692674 0.146913221465714 no 2891 0.114230644077388 4250 17224265 SGTC_225 nsc-122657 1.016 µM -1.20615470264685 0.146512479500035 no 2892 0.113878922956564 4295 275685 SGTC_820 1582-0060 59.9 µM -1.20706521544165 0.146312569378674 no 2893 0.113703514790182 4307 3848840 SGTC_1295 1013-0063 9.78 µM -1.2070811982413 0.146309061868043 no 2894 0.113700437462067 4312 6826038 SGTC_2623 humulene 100 µM -1.20834414176 0.146032080675039 no 2895 0.113457457992588 4292 6187145 An anti-inflammatory. SGTC_810 3825-7150 143 µM -1.2129274258078 0.14502986287007 no 2896 0.112578784447628 4354 22330411 YGL099W LSG1 SGTC_3096 9117468 49.47 µM -1.2134862420128 0.144907985036673 no 2897 0.112471985647829 4209 41316311 SGTC_2876 9059903 25.97 µM -1.21359737021583 0.144883756194324 no 2898 0.112450755884526 4280 6916095 SGTC_1047 2043-3044 82 µM -1.21650080408751 0.144251698540331 no 2899 0.111897102461274 4279 669592 SGTC_2098 5376439 882.5 nM -1.21717320725909 0.144105586459217 no 2900 0.111769160920743 4331 2844116 SGTC_942 3253-1115 227 µM -1.21752191771111 0.14402985157274 no 2901 0.11170285124318 4327 46497897 SGTC_1079 idarubicin 2.36 µM -1.21757014174444 0.144019380120569 no 2902 0.111693683328872 4300 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_866 0495-0101 262 µM -1.21846329894387 0.143825531195649 no 2903 0.11152398170896 4289 635694 SGTC_763 3453-1109 128 µM -1.21862681482724 0.143790061130979 no 2904 0.111492933361934 4325 1560353 SGTC_762 1165-0429 115 µM -1.21914208382857 0.143678326956215 no 2905 0.111395134697706 4303 5967793 SGTC_3187 9109394 49.47 µM -1.22071281155508 0.143338082085044 no 2906 0.111097387636201 4315 17098090 SGTC_301 4119-0100 24.5 µM -1.22161576708928 0.143142733891515 no 2907 0.110926481638786 4326 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_367 0335-0881 7.1 µM -1.22171251939559 0.143121812870973 no 2908 0.110908180120973 4255 23828853 SGTC_424 splitomicin 100 mM -1.22253833272813 0.142943329014581 no 2909 0.110752058556907 4342 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2975 9084847 53.72 µM -1.22267505745179 0.142913793083718 no 2910 0.110726225692647 4335 27211724 SGTC_2570 licareol 100 µM -1.22278713724808 0.142889584144808 no 2911 0.110705052478836 4284 443158 SGTC_3048 9093155 49.47 µM -1.22385942551531 0.142658112823105 no 2912 0.110502631055834 4277 25236002 SGTC_2251 lansoprazole 556 µM -1.22595145507621 0.142207243506323 no 2913 0.11010847187312 4247 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1656 st012921 11 µM -1.22664415594721 0.142058166971779 no 2914 0.109978182674378 4206 6732821 SGTC_2584 androsterone 48.74 µM -1.22898331007161 0.141555538287102 no 2915 0.10953903183193 4234 2754130 A steroid. SGTC_2068 5226020 147 µM -1.23107939843275 0.14110616347431 no 2916 0.109146584949738 4319 1810509 SGTC_1870 st057514 26.5 µM -1.23164219584045 0.140985671752383 no 2917 0.10904138566656 4306 5393161 SGTC_1443 4112-3303 14 µM -1.23221015987198 0.140864144654934 no 2918 0.108935294529121 4351 704433 SGTC_2865 9030313 51.95 µM -1.23231721719983 0.140841245592577 no 2919 0.108915305390977 4285 42562754 SGTC_1384 3089-0840 101 µM -1.23253440650644 0.140794797573704 no 2920 0.108874761134464 4307 1069836 SGTC_2977 9011197 71.43 µM -1.23256411864934 0.140788444154896 no 2921 0.108869215403485 4377 2704722 SGTC_895 0964-0006 13.7 µM -1.23383403526553 0.140517076667781 no 2922 0.108632377006135 4311 6738897 SGTC_1423 4048-0112 5.59 µM -1.23505406323534 0.140256704486585 no 2923 0.108405192041595 4367 X1423 SGTC_3116 9124943 49.47 µM -1.23537238666311 0.140188823451853 no 2924 0.10834597238358 4284 41905195 YPL160W CDC60 SGTC_821 1114-0266 29.2 µM -1.23578394255236 0.140101094097879 no 2925 0.10826944263012 4335 3123235 SGTC_2771 fluoxetine 41.05 µM -1.23629220865446 0.139992800987087 no 2926 0.108174983094928 4336 3386 A selective serotonin reuptake inhibitor. SGTC_216 k038-0035 28.382 µM -1.23820379907479 0.139586019603904 no 2927 0.107820251621123 4236 4444231 YPR107C YTH1 SGTC_1842 st055362 61.2 µM -1.2392732721447 0.139358789556266 no 2928 0.107622156710863 4274 676032 SGTC_1091 telmisartan 47.6 µM -1.240699104308 0.139056235797834 no 2929 0.107358462659348 4357 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_686 1319-0111 510 µM -1.24197157041816 0.138786603316455 no 2930 0.107123525773084 4362 4562600 SGTC_487 nimodipine 119 µM -1.24283730405525 0.138603360128969 no 2931 0.106963896453666 4312 4497 L-type voltage-gated calcium channels inhibitor SGTC_2490 carminic acid 95.39 µM -1.2446988676556 0.138209895750198 no 2932 0.106621231184515 4287 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1799 st045822 46.1415 µM -1.24478626758426 0.138191441434471 no 2933 0.106605162635188 4311 3674992 SGTC_1242 0402-0103 60.1 µM -1.24531987799816 0.138078807131666 no 2934 0.106507095832453 4250 432868 SGTC_2626 ethyl orsellinate 100 µM -1.24553968224181 0.138032429138232 no 2935 0.106466719202626 4282 75653 A natural product. SGTC_1668 st014914 51.6 µM -1.24684845193431 0.13775650288078 no 2936 0.106226535396588 4335 2839556 SGTC_1621 st003705 32.4 µM -1.2474223890044 0.137635619252114 no 2937 0.10612133070962 4333 24207032 SGTC_2741 miltefosine 3.04 µM -1.24785121126982 0.137545347226359 no 2938 0.10604277522293 4348 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2489 cantharidin 73.42 µM -1.24907494649857 0.137287959143238 no 2939 0.105818831542123 4275 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1526 st051518 75 µM -1.24945102251432 0.137208925241995 no 2940 0.105750078309159 4312 673993 SGTC_3176 9106582 49.47 µM -1.25024086961088 0.13704303686252 no 2941 0.105605785675595 4304 17018027 SGTC_237 nikkomycin 200 µM -1.25339074518907 0.136382844586188 no 2942 0.105031768955237 4344 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3190 9110366 49.47 µM -1.25356643042805 0.136346086337116 no 2943 0.104999819626796 4324 17123768 SGTC_374 0880-0231 82.3 µM -1.25386131757917 0.136284402963107 no 2944 0.104946208589076 4202 6833587 SGTC_151 3013-0144 2.285 µM -1.2573479383989 0.13555653232157 no 2945 0.104313836121766 4151 906558 YHR107C CDC12 SGTC_3104 9120930 49.47 µM -1.25881059242259 0.135251981601075 no 2946 0.104049376735975 4346 17014836 SGTC_134 0269-0018 6.916 µM -1.26083957780066 0.134830287744102 no 2947 0.103683325585768 4299 4378915 SGTC_2408 sulbentine 18.36 µM -1.26285400955282 0.134412511867722 no 2948 0.103320825276541 4232 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2220 6782180 200 µM -1.26322083012319 0.134336532189493 no 2949 0.10325491446238 4256 833803 SGTC_1815 st051655 58.2 µM -1.26391257522262 0.134193331038968 no 2950 0.103130703850593 4290 5984156 SGTC_1456 k015-0012 13 µM -1.26398465004013 0.134178416552573 no 2951 0.103117768251491 4352 2989616 SGTC_2086 5274770 176.623 µM -1.26410994136391 0.13415249265189 no 2952 0.103095284445863 4374 689278 SGTC_538 2922-0838 53.3 µM -1.26493317713472 0.133982243348115 no 2953 0.102947641514355 4346 777039 SGTC_2308 7584454 197.62 µM -1.26649565058687 0.133659524408562 no 2954 0.102667842810409 4383 893577 SGTC_75 0159-0059 199.013 µM -1.27009131920199 0.13291889337521 no 2955 0.102026051717479 4418 5377270 SGTC_1383 3049-0032 20.7 µM -1.27264279363369 0.1323950610482 no 2956 0.101572412948868 4403 712864 SGTC_1216 1165-0504 9.65 µM -1.27321721637916 0.132277325240401 no 2957 0.101470486476715 4350 6304004 SGTC_3107 9121808 49.47 µM -1.27345636034997 0.132228330692662 no 2958 0.101428074366535 4292 662681 SGTC_1009 4106-0057 9.87 µM -1.2764005587239 0.131626163977574 no 2959 0.100906979419963 4355 2928005 SGTC_1569 carminic acid 40.6 µM -1.27689064256891 0.131526112848095 no 2960 0.100820429100994 4425 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1927 st060202 13.8 µM -1.28048084539829 0.130794770073301 no 2961 0.100188038545879 4277 688887 SGTC_1853 st056710 91.2 µM -1.2830293539762 0.130277334621509 no 2962 0.0997408961206069 4407 269167 SGTC_1956 st077085 54 µM -1.28349334142039 0.13018328171245 no 2963 0.099659645446224 4387 24208685 SGTC_700 3453-2283 142 µM -1.2835484191639 0.130172120259291 no 2964 0.0996500037770231 4390 565664 SGTC_2138 5575593 77.673 µM -1.28633597302169 0.129608089772591 no 2965 0.0991629165632825 4355 762213 SGTC_742 0kpi-0133 140 µM -1.2865764473951 0.129559511901509 no 2966 0.099120978652642 4377 2728852 SGTC_2112 5488546 200 µM -1.28985542058355 0.128898389789976 no 2967 0.0985504307019786 4317 600757 SGTC_2074 5212007 75.395 µM -1.29472273548464 0.127921339515377 no 2968 0.0977079470089515 4274 758611 SGTC_2127 5253358 187.912 µM -1.29521984475673 0.12782184167945 no 2969 0.0976222004447225 4266 20612 SGTC_696 1560-0013 611 µM -1.30020748509584 0.126826527728723 no 2970 0.0967649329520178 4408 1650269 SGTC_61 0978-8327 98.565 µM -1.30133987480944 0.126601306107033 no 2971 0.0965710720523196 4280 6150059 YHR072W ERG7 SGTC_2457 5731572 11.68 µM -1.30242728266842 0.126385293282696 no 2972 0.0963851805641134 4417 2865357 SGTC_1207 2099-0101 141 µM -1.30386093658896 0.126100891593553 no 2973 0.0961405006471869 4369 5837381 SGTC_2116 5511452 16.8835 µM -1.30505845347328 0.125863675901981 no 2974 0.0959364722084767 4380 870744 SGTC_1114 scopoletin 1.73284 µM -1.30723226109332 0.125433862753223 no 2975 0.0955669209956418 4382 5280460 A coumarin with genotoxic properties. SGTC_2723 salbutamol 83.58 µM -1.30768106233579 0.125345251879903 no 2976 0.0954907546174497 4373 9884233 β2-adrenoceptor agonist SGTC_113 0099-0221 2.5 µM -1.30828490592083 0.125226098564082 no 2977 0.0953883464025067 4342 89219 SGTC_880 0833-0487 87.2 µM -1.30831798599861 0.125219573330041 no 2978 0.0953827385583968 4371 76075 SGTC_2332 7982454 138.89 µM -1.30956367338278 0.124974027171707 no 2979 0.0951717421234301 4289 2981748 SGTC_2381 9035592 200 µM -1.31319042307571 0.124261049068128 no 2980 0.0945593951299347 4380 4749657 SGTC_1429 4049-0205 9.46 µM -1.31437100250761 0.124029575456701 no 2981 0.0943606919269299 4421 22774478 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.31595615479113 0.123719252924125 no 2982 0.0940943796260655 4402 16486 A toxic proline analog. SGTC_639 0833-0042 114 µM -1.3163791530015 0.123636535258459 no 2983 0.0940234079567345 4390 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1505 k297-0037 20.6 µM -1.31889604503421 0.123145155605748 no 2984 0.0936019342737496 4370 4089396 SGTC_976 1348-1067 47.6 µM -1.3216480293232 0.12260944658416 no 2985 0.0931426910057479 4402 5310671 YGL099W LSG1 SGTC_806 3966-4455 5.86 µM -1.32227224090723 0.122488163615684 no 2986 0.0930387564356601 4354 714982 SGTC_70 0141-0289 43.283 µM -1.32316322831944 0.122315192556488 no 2987 0.0928905508075611 4338 352408 SGTC_1158 4092-0494 91.8 µM -1.32833962956765 0.12131366799573 no 2988 0.0920329667152602 4460 1148199 SGTC_520 3584-0023 682 µM -1.33053785171044 0.120890107481233 no 2989 0.0916705618009696 4394 1340790 SGTC_191 3914-0123 66.505 µM -1.33175495591498 0.120656040056081 no 2990 0.0914703620038119 4412 3144412 SGTC_1899 st063254 59.6 µM -1.3319530685558 0.120617970233449 no 2991 0.0914378054180717 4337 3093813 SGTC_2391 6285546 200 µM -1.33222503053454 0.120565723111356 no 2992 0.0913931268858087 4394 846083 SGTC_1465 k213-0056 144 µM -1.33253618950699 0.120505965330452 no 2993 0.0913420288339725 4280 24048857 YMR208W ERG12 SGTC_924 2046-0044 21.3 µM -1.33266841171405 0.12048057849872 no 2994 0.0913203219180544 4376 3623589 SGTC_1211 1056-0033 32.3 µM -1.33529831763049 0.119976415554049 no 2995 0.0908893645228682 4437 6741922 SGTC_2111 5486399 200 µM -1.33768900971081 0.119519402789785 no 2996 0.0904989175473733 4346 689674 SGTC_514 4466-0038 2.65 nM -1.33903590124692 0.119262467977584 no 2997 0.0902794928419275 4184 5722064 SGTC_495 decylubiquinone 155 µM -1.34108743430076 0.118871864334335 no 2998 0.0899460332836664 4393 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1224 0823-0416 294 µM -1.34164495485371 0.118765870973475 no 2999 0.0898555713434549 4421 3598164 SGTC_1481 3346-2004 36 µM -1.3416820072625 0.11875882909882 no 3000 0.089849561706242 4476 2770522 SGTC_3212 9128307 49.47 µM -1.34315279492373 0.118479541543028 no 3001 0.0896112516316964 4309 27243542 SGTC_2472 5377652 49.4 µM -1.34581577133139 0.117975051320573 no 3002 0.0891809689301541 4452 1610903 SGTC_1457 k015-0032 57.3 µM -1.34701357682892 0.117748628046442 no 3003 0.0889879300369859 4385 4302660 SGTC_3151 9099821 49.47 µM -1.34897514252552 0.117378494362516 no 3004 0.0886724752205817 4339 17174189 SGTC_326 k292-0812 17.5 µM -1.34956737890211 0.117266905622857 no 3005 0.0885773969121566 4376 3579357 SGTC_1279 0874-0590 65.2 µM -1.35079369996187 0.117036082049035 no 3006 0.0883807633842478 4463 3523074 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.35079747818201 0.117035371393564 no 3007 0.088380158071406 4402 5377381 SGTC_1779 st039427 55 µM -1.35333955087058 0.116557919119166 no 3008 0.0879735897032666 4395 1124498 SGTC_2692 st077426 47.7 µM -1.35348798730319 0.116530082525855 no 3009 0.0879498925753521 4399 25238571 SGTC_1282 0886-0010 32.4 µM -1.35635373980042 0.115993586006112 no 3010 0.0874933222571037 4427 2836211 YNL267W PIK1 SGTC_64 000l-0018 272.079 µM -1.35661950662722 0.115943920886203 no 3011 0.0874510702092244 4326 6811119 SGTC_2959 9079155 11 µM -1.35711264406077 0.115851805934016 no 3012 0.0873727107566367 4421 16189457 SGTC_2646 retinol 96.75 µM -1.35711864357648 0.115850685582501 no 3013 0.0873717577574399 4404 445354 A vitamin A analog and teratogen. SGTC_1977 st070720 65.3 µM -1.36349013552597 0.11466521056342 no 3014 0.0863640456246428 4433 682188 SGTC_2988 9073640 71.4286 µM -1.36547669182258 0.11429736482776 no 3015 0.0860516369985675 4445 9102229 SGTC_3054 9094397 49.47 µM -1.36714929083862 0.113988305986266 no 3016 0.0857892580137894 4411 2598354 SGTC_1754 st042065 16.137 µM -1.36839661383908 0.113758216513149 no 3017 0.0855939818008674 4178 1126236 YIL048W NEO1 SGTC_488 nitrendipine 139 µM -1.36891848807168 0.113662046422256 no 3018 0.0855123779579082 4440 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.37110342892704 0.113260038566892 no 3019 0.0851713581147393 4458 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2807 7945238 51.95 µM -1.37137290274342 0.11321052835834 no 3020 0.08512937003992 4398 17148797 SGTC_2787 5284540 71.43 µM -1.37230306040984 0.113039749875512 no 3021 0.0849845566597315 4435 736958 SGTC_2186 6124449 200 µM -1.37285010721176 0.112939397081305 no 3022 0.0848994749063736 4422 3834182 YLR033W RSC58 SGTC_1425 4048-4433 7.33 µM -1.38022542889027 0.111592638335806 no 3023 0.0837586234214314 4487 23734946 SGTC_2969 9091408 28.7 µM -1.38484565298622 0.110754845472599 no 3024 0.0830498339784498 4361 4286311 SGTC_1162 k048-0130 20.1 µM -1.39089795353418 0.109664204089245 no 3025 0.0821281867416246 4399 6797406 SGTC_1192 1488-0095 21.4 µM -1.39184864529197 0.109493589934631 no 3026 0.081984117855856 4459 915875 SGTC_2455 5377712 9.75 µM -1.39841845841633 0.108319759281315 no 3027 0.0809937216981716 4426 2243908 SGTC_345 1362-0200 395 µM -1.39852115843814 0.108301482004701 no 3028 0.0809783117252221 4419 1419823 SGTC_995 3931-2021 34.6 µM -1.40354194399917 0.107410649686851 no 3029 0.0802276467396587 4455 730143 SGTC_2301 7769476 200 µM -1.4093746332796 0.10638240861688 no 3030 0.0793622103724148 4424 977820 SGTC_3013 9080133 71.4286 µM -1.41163230513501 0.105986319267218 no 3031 0.0790291275858295 4500 17050193 SGTC_2456 5770359 74.46 µM -1.41555350810417 0.105300912311337 no 3032 0.0784531357889287 4439 3118787 SGTC_3328 9140624 29.0385 µM -1.41936618943444 0.104637554886381 no 3033 0.0778961421339524 4446 4904392 SGTC_1629 st005085 44.9 µM -1.41942200688234 0.104627865902314 no 3034 0.077888010123584 4405 24207091 SGTC_3078 9116413 49.47 µM -1.42059913968376 0.104423686491873 no 3035 0.0777166643739759 4395 17177322 SGTC_681 1642-0006 26.6 µM -1.42135745634691 0.104292305775678 no 3036 0.0776064339553939 4459 4446530 SGTC_592 k241-0073 46.5 µM -1.42444350261643 0.103758874505894 no 3037 0.0771590643939965 4479 4230158 SGTC_3043 9092303 49.47 µM -1.42756680857613 0.103221020899094 no 3038 0.0767082914073334 4462 25236084 SGTC_3186 9110464 49.47 µM -1.43208698778652 0.102446206098226 no 3039 0.0760594639663376 4440 17018021 SGTC_49 0717-0965 32.132 µM -1.43716566289128 0.101580713083329 no 3040 0.0753354635570319 4511 5889349 YGL099W LSG1 SGTC_208 k072-0098 12.366 µM -1.43992461326561 0.101112778728806 no 3041 0.0749443643179991 4451 5948901 SGTC_2258 7960471 200 µM -1.44129184801342 0.100881470628993 no 3042 0.0747511246811822 4462 2974708 SGTC_193 1273-0060 1.558 µM -1.44137330222123 0.100867702433373 no 3043 0.0747396242714227 4297 2847393 YHR072W ERG7 SGTC_1697 st025554 27.742 µM -1.4414831810436 0.100849131799075 no 3044 0.0747241127677162 4462 1269519 SGTC_3214 9129694 49.47 µM -1.44531904100441 0.100202394375582 no 3045 0.0741841459569519 4481 17158655 SGTC_217 ketoconazole 989 nM -1.44631428659823 0.1000350887536 no 3046 0.0740445352152304 4275 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3244 9134489 49.47 µM -1.44755499900207 0.0998268047282843 no 3047 0.07387077216002 4477 16584271 SGTC_814 3342-0569 96 µM -1.45045839755319 0.0993406363915225 no 3048 0.0734653662179563 4493 4346283 SGTC_2953 9074162 66.49 µM -1.45254260662873 0.098992708536349 no 3049 0.0731753956188805 4445 16451992 SGTC_1948 st076329 66.6 µM -1.45737588139848 0.0981892970331653 no 3050 0.072506325493298 4393 24208413 SGTC_135 0933-0004 26.348 µM -1.45874494056958 0.097962595555411 no 3051 0.0723176609527711 4404 21230617 YGL099W LSG1 SGTC_2265 7929201 200 µM -1.46330666708829 0.0972099912796695 no 3052 0.0716917421189892 4446 1265108 SGTC_1791 st048313 56.1 µM -1.46446469253433 0.0970196145559174 no 3053 0.0715335116680072 4488 1204976 SGTC_1367 1812-0510 76.9 µM -1.46594181343695 0.096777176644566 no 3054 0.0713320696837024 4531 1142582 YDR527W RBA50 SGTC_1827 berberine 7.24 µM -1.46811254129177 0.0964217056664218 no 3055 0.0710368277511132 4385 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1059 3448-6867 171 µM -1.47096236816533 0.0959564856079039 no 3056 0.0706506471189214 4449 3934407 SGTC_3114 9122766 49.47 µM -1.47251549067824 0.0957036420783648 no 3057 0.0704408635125183 4474 17176985 SGTC_303 1348-1668 34.2 µM -1.47289265046868 0.0956423156702582 no 3058 0.0703899920667663 4488 5380509 SGTC_1774 st048371 48.465 µM -1.47434724217675 0.0954060689887525 no 3059 0.0701940607399997 4480 4242727 SGTC_3345 9148410 3.559 µM -1.47614169583219 0.0951152160119955 no 3060 0.0699529287675047 4421 4903596 SGTC_2358 9037157 4 µM -1.47733247504971 0.0949225700385726 no 3061 0.0697932684563226 4488 2388925 SGTC_1342 1486-1464 234 µM -1.48038590300451 0.0944298959767146 no 3062 0.0693851449518967 4488 3253938 SGTC_1506 4226-2149 212 µM -1.48486562494092 0.0937105039333439 no 3063 0.0687897117884998 4493 991114 SGTC_548 1436-0017 110 µM -1.48526730568051 0.0936461968170048 no 3064 0.0687365144767171 4516 9677137 SGTC_2135 5326629 150.42 µM -1.48855440839011 0.0931211717470165 no 3065 0.0683023723836217 4442 5020077 SGTC_460 trequinsin 123 µM -1.48936042374169 0.0929927655096905 no 3066 0.0681962421249307 4572 5537 A vasodilator. SGTC_939 1165-0479 45.3 µM -1.49069191407408 0.0927809326705396 no 3067 0.0680211999911414 4460 1377347 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.49113899091266 0.0927098852708045 no 3068 0.0679625036430402 4411 4000243 SGTC_1635 st007035 42.4 µM -1.49220754504713 0.0925402385762947 no 3069 0.0678223725037574 4443 3716403 SGTC_277 nystatin 15.5 µM -1.4926304097308 0.0924731668379503 no 3070 0.067766979322454 4517 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_748 act1.228 77.9 µM -1.49622662430081 0.0919042143396405 no 3071 0.0672973043544448 4480 4421505 YNR035C ARC35 SGTC_2643 anethole 100 µM -1.51051599956556 0.0896691175053815 no 3072 0.0654559049852085 4504 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_489 paxilline 115 µM -1.51080034668267 0.0896250546634472 no 3073 0.0654196631852279 4462 105008 A toxic potassium channel blocker. SGTC_246 cycloheximide 667 µM -1.51229103465772 0.0893943189041724 no 3074 0.0652299203951012 4429 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1829 berberine 14.4 µM -1.51526704223846 0.0889350004390981 no 3075 0.0648523955437102 4465 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.5159860750138 0.0888242885560755 no 3076 0.0647614367576559 4405 4330530 SGTC_1393 3470-5649 58.2 µM -1.51635705956311 0.0887672069712777 no 3077 0.0647145453815973 4499 4108395 SGTC_2236 dapsone 200 µM -1.51651113580024 0.0887435080414695 no 3078 0.0646950783410337 4528 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_338 4055-0136 114 µM -1.51717202686593 0.0886419078463942 no 3079 0.0646116284517785 4477 2900563 SGTC_2664 lyso-paf C-16 73.48 µM -1.52318558764522 0.0877214080822466 no 3080 0.0638561403997537 4478 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1459 k035-0031 35.7 µM -1.52359464147893 0.0876590539455415 no 3081 0.063805001291847 4248 3877128 YMR208W ERG12 SGTC_1818 st052136 56.3 µM -1.52781493783455 0.0870176624161813 no 3082 0.0632792461836319 4152 674169 SGTC_522 1273-0010 11.6 µM -1.52828365358842 0.0869466448459481 no 3083 0.0632210633317474 4519 5705015 SGTC_1167 k781-0610 148 µM -1.53015378780019 0.0866637220272604 no 3084 0.0629893334959449 4538 4525169 SGTC_158 k038-0087 26.446 µM -1.54303397460364 0.084733808638822 no 3085 0.0614112664310643 4433 X158 SGTC_975 1335-0046 28.5 µM -1.54960057661091 0.083762386180895 no 3086 0.0606187072438703 4513 16486740 SGTC_1619 st003326 88.7 µM -1.55109492965042 0.083542493921622 no 3087 0.0604394680554081 4496 2849032 SGTC_2085 5307070 144.047 µM -1.55388490323059 0.0831331140613073 no 3088 0.0601059367070055 4471 2840351 SGTC_448 monastrol 171 µM -1.55455423370545 0.0830351262519387 no 3089 0.0600261353761887 4447 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_99 0109-0120 622.8 µM -1.55924707020258 0.0823505484600848 no 3090 0.0594689570024064 4532 759414 SGTC_2033 5192550 145 µM -1.56718999081678 0.0812015548154923 no 3091 0.0585351446627902 4533 182073 SGTC_993 3909-8757 62.7 µM -1.56873832629156 0.0809789938791295 no 3092 0.0583544621249247 4483 4288324 YLR208W SEC13 SGTC_2350 9023895 38.85 µM -1.5698868829661 0.0808141956571508 no 3093 0.0582207148663194 4503 2997209 SGTC_1975 st070967 30.8 µM -1.56994025908134 0.0808065432600892 no 3094 0.0582145051791305 4525 261391 SGTC_1813 st051246 8.6015 µM -1.57383286084948 0.0802499445411388 no 3095 0.0577630474412189 4483 5291959 SGTC_877 0771-0151 33.1 µM -1.57922152982875 0.0794842132889566 no 3096 0.0571426266421506 4535 6166523 SGTC_567 1080-0542 68.4 µM -1.58506003413981 0.0786608152006728 no 3097 0.0564763474389657 4430 5950415 SGTC_254 nsc-64875 3.808 µM -1.59822990958136 0.0768272385009225 no 3098 0.054995909797676 4545 56993 SGTC_3106 9121286 49.47 µM -1.60499181097862 0.0758985274513533 no 3099 0.0542478034259796 4507 15943471 SGTC_2404 5161160 200 µM -1.60917868286592 0.075327783537241 no 3100 0.0537886381171324 4501 2831543 SGTC_977 1348-1378 135 µM -1.6145286158857 0.0746032622620878 no 3101 0.0532064075112727 4533 X977 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.61487519146068 0.074556510912011 no 3102 0.0531688628474163 4580 4174840 SGTC_1045 1348-1485 165 µM -1.61503772415763 0.0745345937503444 no 3103 0.0531512628548129 4528 6810614 SGTC_2452 5863136 48.41 µM -1.6155600072275 0.0744641983683861 no 3104 0.0530947382519272 4513 2184096 SGTC_1092 toremifene 6.32 µM -1.61675633616423 0.0743031437091525 no 3105 0.052965443994454 4558 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1413 3910-0535 34.4 µM -1.62320213409982 0.0734399584285983 no 3106 0.0522731009011675 4581 2876951 SGTC_3117 9124945 49.47 µM -1.62353336439366 0.073395809962306 no 3107 0.0522377185219197 4479 17592065 SGTC_3030 9087619 49.47 µM -1.62452599589193 0.0732636273279931 no 3108 0.0521317984439009 4552 25236973 SGTC_1882 5615643 20 µM -1.62458975584108 0.0732551430362432 no 3109 0.0521250006878984 4540 2253075 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.62513155839406 0.0731830777785967 no 3110 0.0520672649098795 4573 6710655 SGTC_2087 5276107 200 µM -1.62578093139011 0.0730967760378961 no 3111 0.0519981331138899 4550 144405 SGTC_1076 itraconazole 331 nM -1.62797213592516 0.0728061394381088 no 3112 0.0517653970924805 4569 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_642 0335-0876 158 µM -1.629322147124 0.0726275178618141 no 3113 0.0516224200602885 4598 6812350 SGTC_3015 9080845 49.47 µM -1.62959594741871 0.0725913319930385 no 3114 0.0515934607408313 4594 5296973 SGTC_1734 st037168 69.4 µM -1.63019841148795 0.0725117580365485 no 3115 0.0515297847799263 4554 708907 SGTC_777 1315-0167 517 µM -1.63385513629449 0.0720302076584779 no 3116 0.0511446359378244 4577 4221767 SGTC_2575 plumbagin 510 nM -1.63424276212302 0.0719793056703788 no 3117 0.0511039434293751 4495 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2029 5175081 200 µM -1.63652932457087 0.0716796014312441 no 3118 0.0508644267802862 4517 1380876 SGTC_1698 5-fluorocytosine 1.055 µM -1.63736593883951 0.071570184280593 no 3119 0.0507770153674587 4573 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2874 9043904 71.43 µM -1.63824235642567 0.0714556989189301 no 3120 0.0506855735421125 4480 4463428 SGTC_868 0527-0199 213 µM -1.64309197663051 0.0708247378737827 no 3121 0.0501819523303288 4565 2849450 SGTC_2662 daunorubicin 22.37 µM -1.64331754946875 0.0707954941790546 no 3122 0.0501586245803464 4452 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1217 1183-1422 255 µM -1.64380475953288 0.0707323629931025 no 3123 0.0501082689608002 4597 2849664 SGTC_2698 st077697 67.5 µM -1.64806259684125 0.070182485074657 no 3124 0.0496699133150147 4544 3154499 SGTC_2894 9048625 32.47 µM -1.64998006108354 0.0699359306941057 no 3125 0.0494735071189774 4569 4092861 SGTC_1036 k216-0215 33.5 µM -1.65197042879804 0.0696807076704045 no 3126 0.0492702896251329 4524 622330 SGTC_2568 diosmetin 100 µM -1.65805133888559 0.0689053989140668 no 3127 0.0486535522516088 4573 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2935 9038016 29.96 µM -1.66011627440192 0.0686436400566913 no 3128 0.0484455317755645 4531 6463195 SGTC_1452 4194-0072 190 µM -1.6610211690378 0.0685291742199775 no 3129 0.0483545976090813 4610 1343545 SGTC_1396 3511-0007 98.6 µM -1.66351191800465 0.0682148640424262 no 3130 0.0481050036020727 4590 X1396 SGTC_1042 0350-0096 82 µM -1.66470966386424 0.0680641159728143 no 3131 0.0479853470193606 4568 3122515 SGTC_310 1273-0058 1.06 µM -1.66852927186558 0.067585098359157 no 3132 0.047605353042987 4273 2734232 SGTC_758 0868-0029 16 µM -1.66960018427078 0.0674512637006633 no 3133 0.047499246968322 4522 762687 SGTC_230 MPP+ 141.667 µM -1.67153139091504 0.0672104337137828 no 3134 0.0473083818464159 4554 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.67442559193041 0.0668507595278949 no 3135 0.0470234933274052 4623 91467 include heat shock SGTC_3040 9091894 49.47 µM -1.6748141956033 0.0668025797711018 no 3136 0.0469853463863549 4489 25236966 SGTC_2998 9066762 71.4286 µM -1.67910630783365 0.0662722218053922 no 3137 0.0465656635531198 4582 4945196 SGTC_856 0433-0016 11.3 µM -1.68021234550085 0.0661360832820272 no 3138 0.046458004095906 4605 3911780 SGTC_618 k072-0232 33.2 µM -1.68067240289471 0.066079520173024 no 3139 0.0464132819216345 4611 5872756 YGL099W LSG1 SGTC_2541 muurolladie-3-one 83.07 µM -1.68358057272257 0.0657228335159312 no 3140 0.0461313779214226 4517 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_398 bronopol 33.3 µM -1.68447834717075 0.0656130236216244 no 3141 0.0460446303188044 4508 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_627 1391-0720 175 µM -1.68634653159324 0.0653849755850273 no 3142 0.0458645367522171 4577 997839 SGTC_743 1275-0778 158 µM -1.68789288583284 0.0651966786090168 no 3143 0.0457158962682718 4560 2849257 YMR203W TOM40 SGTC_2004 4023728 41.89 µM -1.70056844087462 0.0636690196079419 no 3144 0.0445120272444692 4540 360084 YDR527W RBA50 SGTC_1320 1313-0481 95.3 µM -1.7011934301706 0.0635944224761944 no 3145 0.0444533355607589 4554 6813365 YLR208W SEC13 SGTC_83 0170-0301 39.027 µM -1.70367758967145 0.0632985917217754 no 3146 0.044220668554314 4612 3089716 SGTC_2954 9074818 52.69 µM -1.70529086355753 0.0631070465508902 no 3147 0.0440700953615063 4583 16648742 SGTC_415 dibenzyl ketone 100 µM -1.70733940925507 0.0628644721324721 no 3148 0.043879492589783 4569 7593 SGTC_2035 5154463 94.595 µM -1.7082626339562 0.0627553880914644 no 3149 0.0437938106537864 4598 2769623 SGTC_863 0466-0191 129 µM -1.70833673367529 0.0627466392035943 no 3150 0.0437869395187853 4631 765160 YPR165W RHO1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.70972315327975 0.0625831210807077 no 3151 0.0436585395914116 4590 7104 SGTC_610 4215-0184 155 µM -1.7104975404655 0.0624919324294471 no 3152 0.0435869539292957 4602 5605015 SGTC_1547 harmine 94.2 µM -1.71418726160103 0.0620588679946162 no 3153 0.0432471698093025 4513 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_198 3454-2873 16.191 µM -1.71565968113829 0.0618867044449409 no 3154 0.0431121741457336 4596 710957 SGTC_3111 9122088 49.47 µM -1.7189464127148 0.0615037462384531 no 3155 0.0428120649558238 4547 16876704 SGTC_2272 7805186 180 µM -1.71994376750342 0.0613879047904759 no 3156 0.0427213318402288 4600 2956062 YPR165W RHO1 SGTC_2219 9098279 200 µM -1.73089232376201 0.0601274223433103 no 3157 0.0417354854976135 4561 902349 SGTC_2021 4019055 173 µM -1.7314691774952 0.0600615766466743 no 3158 0.0416840588312981 4383 44827708 YER133W GLC7 SGTC_2328 6201408 200 µM -1.73243150718689 0.0599518559903782 no 3159 0.0415983811248818 4542 2890418 SGTC_1307 1187-1599 12.2 µM -1.73506108158425 0.0596528437757777 no 3160 0.0413649933770826 4621 1538471 SGTC_394 menadione 8.33 µM -1.73525406624239 0.0596309453590157 no 3161 0.0413479069183809 4596 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2283 7944793 200 µM -1.73902482339269 0.0592043316199888 no 3162 0.041015198318094 4574 2970533 SGTC_2766 oltipraz 83.91 µM -1.73957761709642 0.0591419916338326 no 3163 0.040966606167482 4575 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2160 5660466 132.927 µM -1.74726187827427 0.058280739449461 no 3164 0.0402959612656608 4560 2859134 SGTC_2082 5219693 150 µM -1.74783981512043 0.0582163647175871 no 3165 0.0402458844011869 4572 2834649 SGTC_85 0868-0259 160.055 µM -1.75100720794586 0.0578645493707236 no 3166 0.0399723342173143 4561 83173 SGTC_917 harmaline 728.087 nM -1.75157139608408 0.0578020584055827 no 3167 0.0399237673207193 4537 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1981 st071826 47 µM -1.758493168248 0.057039696019704 no 3168 0.0393318164916128 4643 11838600 SGTC_2367 9070478 135.38 µM -1.75905385024855 0.0569782908567932 no 3169 0.039284181230501 4553 572802 SGTC_2293 7624732 200 µM -1.75964227671691 0.0569139031435305 no 3170 0.0392342393138039 4516 894453 SGTC_329 k048-0121 21.3 µM -1.75985693509208 0.0568904287302138 no 3171 0.0392160333368402 4622 6832902 SGTC_553 k007-0256 45.7 µM -1.76354117988272 0.0564887177738348 no 3172 0.0389046291470248 4651 6287000 SGTC_749 1000-0129 128 µM -1.76988966899547 0.0558017595703973 no 3173 0.0383727610811201 4631 708470 SGTC_2899 9053889 58.44 µM -1.77303743923662 0.0554635983438871 no 3174 0.0381112516341479 4620 6470052 SGTC_3303 9125618 40.5795 µM -1.77974295623644 0.0547486278859257 no 3175 0.0375590184802943 4600 22695467 SGTC_1581 himbacine 57.9 µM -1.78255185378378 0.0544513051813801 no 3176 0.0373296415818797 4631 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3267 9137951 49.47 µM -1.78662644274301 0.0540222803344748 no 3177 0.0369989424761655 4644 16643986 SGTC_1504 k297-0033 30 µM -1.78669747227368 0.0540148252349308 no 3178 0.0369931989306374 4538 4388117 SGTC_2720 fluspirilene 36.88 µM -1.78694605555938 0.0539887409054429 no 3179 0.0369731038828185 4625 3396 An atypical antipsychotic. SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.78802545209013 0.0538755933567521 no 3180 0.0368859507856736 4600 6708630 An antioxidant. SGTC_355 1311-2252 105 µM -1.79035439286039 0.053632102179308 no 3181 0.0366984785959242 4586 5338538 SGTC_1926 methyl fluorone black 53.6 µM -1.79068021117531 0.0535981074323074 no 3182 0.0366723135267928 4266 72721 Reacts with homocysteine. SGTC_2096 5468907 200 µM -1.79507266780598 0.0531414781375299 no 3183 0.0363210614160585 4639 759785 SGTC_1007 4101-0031 70 µM -1.79851274780872 0.0527860138455033 no 3184 0.0360478951740558 4618 1146276 SGTC_3252 9135871 49.47 µM -1.79995361958423 0.0526376898745235 no 3185 0.0359339810069457 4646 17682838 SGTC_2162 5663267 200 µM -1.80005192079107 0.0526275827694113 no 3186 0.0359262201497955 4639 6456493 SGTC_2897 9048598 12.99 µM -1.80537505771724 0.0520825660445819 no 3187 0.0355080057508473 4609 6467404 SGTC_1349 flufenamic acid 69 µM -1.81028381166074 0.0515839592265243 no 3188 0.0351258930777423 4574 3371 A non-steroidal anti-inflammatory. SGTC_789 1309-1135 70.6 µM -1.81852191075827 0.0507557111595422 no 3189 0.034492200476347 4611 3092424 SGTC_2594 a-mangostin 100 µM -1.82346546985566 0.0502637983212813 no 3190 0.0341164611466395 4622 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2880 9042983 58.44 µM -1.82405150173842 0.0502057375317706 no 3191 0.0340721432674815 4586 6464714 SGTC_1024 4507-0395 26 µM -1.82439787282966 0.050171446149133 no 3192 0.0340459716808667 4652 4201836 SGTC_1604 st002052 72.4 µM -1.82503955470335 0.0501079677864263 no 3193 0.0339975302735226 4667 6254834 YHR062C RPP1 SGTC_456 gingerol 170 µM -1.8305000339356 0.0495703774053472 no 3194 0.0335876008526358 4630 442793 A herb. SGTC_497 capsazepine 133 µM -1.83383839515518 0.0492439857174532 no 3195 0.0333389932255905 4589 2733484 A calcium channel blocker. SGTC_3235 9132602 49.47 µM -1.83580949495138 0.0490520784375591 no 3196 0.033192918350494 4614 4912240 SGTC_1950 st077106 7.18 µM -1.84041498716517 0.0486060138135524 no 3197 0.0328536674023903 4557 13831864 SGTC_2178 5812956 200 µM -1.84055034922342 0.0485929525534554 no 3198 0.0328437397270682 4617 5403383 SGTC_1314 1222-0010 41.1 µM -1.84890136361544 0.0477925643429411 no 3199 0.0322360283859526 4647 3526027 SGTC_2062 5245942 200 µM -1.85065943487599 0.0476254176056631 no 3200 0.032109281683195 4669 1376160 SGTC_1218 1348-1416 30.7 µM -1.85075227300454 0.0476166041517146 no 3201 0.0321026000475658 4628 6787668 SGTC_956 1185-0240 191 µM -1.85793509196841 0.0469386645960355 no 3202 0.0315891161549843 4633 1416193 SGTC_1055 3448-0672 86 µM -1.86216882588784 0.0465427098647599 no 3203 0.0312896485449577 4616 748378 SGTC_878 0828-0289 13.7 µM -1.86482180399256 0.0462959625697249 no 3204 0.0311031929901628 4622 745350 YLR208W SEC13 SGTC_3266 9136860 49.47 µM -1.86630955429102 0.0461580507213929 no 3205 0.0309990344216624 4399 4871271 YPR165W RHO1 SGTC_2010 4012422 159 µM -1.86708415023224 0.0460863777580362 no 3206 0.0309449187140901 4606 952393 SGTC_2459 5811157 9.22 µM -1.87914662197063 0.0449817370912058 no 3207 0.0301122378495225 4605 2870684 YBR192W RIM2 SGTC_3071 9117417 49.47 µM -1.87994973013435 0.0449089544207702 no 3208 0.0300574646909871 4618 45595590 YGL055W OLE1 SGTC_617 3770-0098 35 µM -1.88002869596882 0.0449018031664377 no 3209 0.0300520835682977 4592 5962639 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.88623849455037 0.0443422998242962 no 3210 0.0296314116540035 4635 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_440 fluspirilene 35.1 µM -1.89018916635874 0.0439892777075598 no 3211 0.0293663325407932 4643 3396 An atypical antipsychotic. SGTC_1841 st054148 70 µM -1.89138546653422 0.0438828275246705 no 3212 0.0292864536064136 4668 675442 SGTC_2820 7989630 71.43 µM -1.89597985383271 0.043475935758143 no 3213 0.0289813542697699 4675 2984098 SGTC_1657 st012939 43.4 µM -1.89961518732213 0.0431561433189703 no 3214 0.0287418188456424 4661 24207257 SGTC_1112 tnp00069 1.16933 µM -1.91173266983539 0.0421038931648007 no 3215 0.0279552458488174 4643 145826 SGTC_2344 7990960 76.95 µM -1.91798484964139 0.0415691467935441 no 3216 0.0275564661121127 4635 140813 SGTC_1745 st081495 74 µM -1.92539574937536 0.040942436255244 no 3217 0.027089933485 4535 13842402 YBL026W LSM2 SGTC_1687 st020778 55.3625 µM -1.9277997214649 0.0407407958891029 no 3218 0.0269400211952167 4696 4259299 SGTC_1901 st060216 58.6 µM -1.92881243930208 0.0406560927373883 no 3219 0.0268770755023402 4643 688792 SGTC_2355 9061122 103.12 µM -1.92956707837033 0.0405930681267735 no 3220 0.0268302506287721 4670 5302957 SGTC_3204 9114183 49.47 µM -1.93034749464478 0.0405279741368661 no 3221 0.026781897959165 4613 17027248 SGTC_2553 4-methylesculetin 85.09 µM -1.93118080042985 0.0404585622420097 no 3222 0.0267303487374467 4658 5319502 SGTC_2770 toltrazuril 17.5 µM -1.93508561924719 0.040134587221802 no 3223 0.0264898949628252 4611 68591 Kills coccidiodes. SGTC_577 r071-0003 38.6 µM -1.94066942131307 0.0396749753048407 no 3224 0.0261491938463403 4643 4568517 YMR134W ERG29 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.94335395747207 0.0394555351217145 no 3225 0.0259867031352774 4658 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_783 0848-0141 92.7 µM -1.94482214255004 0.0393359405601302 no 3226 0.0258981940841439 4627 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2764 methyldopa 94.69 µM -1.94811593573092 0.0390687096981892 no 3227 0.0257005462188181 4629 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1889 st059080 5.18 µM -1.95130245823985 0.0388115902730811 no 3228 0.0255105384130772 4650 176925 Isolated from Daphnopsis sellowiana. SGTC_97 0535-0701 19.132 µM -1.95237690626861 0.0387252047771896 no 3229 0.0254467363914742 4586 2832013 YGL099W LSG1 SGTC_1523 st012844 44.7 µM -1.95528970374328 0.0384918038823409 no 3230 0.025274442894421 4677 4274103 SGTC_3208 9114115 49.47 µM -1.95888574981781 0.0382052374736435 no 3231 0.0250630841257929 4617 650895 SGTC_557 1315-0110 16.2 µM -1.96168896520779 0.0379830599397808 no 3232 0.0248993536678779 4663 6833801 SGTC_2676 harmalol 100 µM -1.96914020387587 0.0373976100655961 no 3233 0.0244684965996868 4669 5459187 A monoamine oxidase inhibitor SGTC_1707 st032323 6.317 µM -1.97008889894058 0.0373236021184299 no 3234 0.024414091480157 4500 3132057 YMR211W DML1 SGTC_3136 9095672 49.47 µM -1.97245929616431 0.0371392096494396 no 3235 0.024278599265315 4561 17217380 SGTC_2203 7227154 166.4 µM -1.97550117284955 0.0369036743499629 no 3236 0.0241056508219164 4689 896304 SGTC_1146 3579-1023 7 µM -1.98042739238907 0.0365248241690937 no 3237 0.0238277622521549 4693 X1146 SGTC_753 1322-0200 289 µM -1.98576792199291 0.0361177125969793 no 3238 0.0235295495800515 4715 5403907 SGTC_328 k915-0120 63.5 µM -1.98749006618789 0.0359872276316965 no 3239 0.0234340578288165 4694 6624543 SGTC_2291 7917025 104.35 µM -1.9986682334551 0.0351496283025261 no 3240 0.0228221311333795 4602 2964612 SGTC_2109 5483026 200 µM -2.00890016414466 0.0343970178277143 no 3241 0.0222738612624161 4693 759335 SGTC_1979 st071809 45.3 µM -2.01129911826583 0.0342224922890104 no 3242 0.0221469357940911 4713 4976333 SGTC_3012 9080433 71.4286 µM -2.0122894776873 0.0341506555616622 no 3243 0.0220947154907651 4681 17688859 SGTC_2919 7978188 46.38 µM -2.01804894465395 0.0337353397945696 no 3244 0.0217930820730408 4661 2980291 SGTC_156 3474-0145 5.642 µM -2.0225218275825 0.0334156744976589 no 3245 0.021561235473266 4628 2265471 SGTC_1368 1852-0141 284 µM -2.02575620281851 0.0331860792816597 no 3246 0.0213948870536255 4646 2838987 SGTC_1550 gossypolone 36.6 µM -2.02622566541353 0.0331528622829935 no 3247 0.0213708323515869 4708 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_785 1270-0111 65.3 µM -2.02805806397643 0.0330234722428564 no 3248 0.0212771611392537 4622 6741994 SGTC_1914 st062367 72.6 µM -2.04371216762955 0.0319349758155878 no 3249 0.0204909952306965 4667 978205 SGTC_572 0960-0087 17.7 µM -2.04482366433041 0.0318588288088788 no 3250 0.0204361229267432 4675 6796365 SGTC_3073 9114972 49.47 µM -2.04751915495207 0.0316747874251448 no 3251 0.0203035690435497 4696 41905075 SGTC_858 0438-0351 2.77 µM -2.0484422489005 0.0316119631701899 no 3252 0.0202583426828688 4706 2799119 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.05168226145287 0.0313922678063113 no 3253 0.0201002758833242 4637 5711223 A potent inhibitor of glutathione S-transferases. SGTC_585 0kpi-0023 191 µM -2.05305840823544 0.0312993382197224 no 3254 0.0200334565532686 4657 64601 SGTC_3124 9127567 49.47 µM -2.05593741947784 0.0311056576957065 no 3255 0.0198942743435837 4669 17592030 SGTC_2167 5876490 200 µM -2.06691929002753 0.0303759543174506 no 3256 0.0193708798733875 4690 686534 SGTC_1744 st037937 38.9 µM -2.07664246846549 0.0297417789824154 no 3257 0.0189172850801801 4703 1016152 SGTC_346 4513-0042 7.16 µM -2.0851104539013 0.0291984576891219 no 3258 0.0185296377803407 4662 2827372 SGTC_2003 4023581 200 µM -2.0946690536737 0.0285950925361454 no 3259 0.0181002110114869 4684 16641307 SGTC_2442 5158906 48.48 µM -2.09620171953375 0.0284993179482013 no 3260 0.0180321502430671 4699 1893835 SGTC_2108 5365811 200 µM -2.09951287061655 0.0282933186224939 no 3261 0.0178858572266417 4716 780283 SGTC_2034 5197015 53.07 µM -2.11275981295867 0.0274815334328017 no 3262 0.0173106654664529 4700 780676 SGTC_2055 5235184 200 µM -2.11285435754805 0.0274758101917841 no 3263 0.0173066177367903 4687 2836034 SGTC_816 0325-0417 81.3 µM -2.11660514758038 0.0272495572200965 no 3264 0.0171466864427203 4713 68101 SGTC_1269 0831-0796 3.05 µM -2.11714150952567 0.0272173304781375 no 3265 0.0171239198468515 4708 927758 SGTC_3038 9091290 49.47 µM -2.11993193309194 0.027050183401417 no 3266 0.0170058929712479 4703 25236843 SGTC_2054 5233173 129 µM -2.15020688350027 0.0252911518910376 no 3267 0.0157694269595701 4714 6889 SGTC_635 k038-0028 24.7 µM -2.15835471977196 0.0248344580493683 no 3268 0.0154501316739966 4728 4035102 SGTC_2544 sphondin 68.51 µM -2.16042686751831 0.0247194217415899 no 3269 0.015369819699705 4679 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3237 9133362 49.47 µM -2.16929070545583 0.0242323751719584 no 3270 0.0150303102169024 4723 43845137 SGTC_586 0957-0265 8.15 µM -2.16970591584447 0.0242097593763303 no 3271 0.0150145658068365 4662 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2714 st079313 56.9 µM -2.17178297287838 0.0240968916355467 no 3272 0.0149360182943762 4720 2939799 SGTC_1205 4161-2785 76 µM -2.18569278029692 0.0233523680856821 no 3273 0.0144190447273875 4706 3498106 SGTC_2719 novobiocin 32.65 µM -2.18947521616346 0.0231532933698451 no 3274 0.0142811589918306 4731 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1377 2944-0135 198 µM -2.19645775197445 0.0227895459274224 no 3275 0.0140295979600288 4715 1894137 SGTC_445 e6 berbamine 66 µM -2.19910709253328 0.0226527973983214 no 3276 0.0139351541701443 4716 6610268 A calcium/calmodulin antagonist. SGTC_779 1360-0071 233 µM -2.20975318218773 0.0221102421501338 no 3277 0.0135611482925062 4733 7566 SGTC_175 3793-3120 23.7 µM -2.21197456910002 0.0219984277541913 no 3278 0.013484211074175 4691 5322297 SGTC_82 0054-0107 293.755 µM -2.22123297986444 0.0215375296409246 no 3279 0.0131675927619017 4711 3104697 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.22255192583396 0.021472539344553 no 3280 0.0131230144747731 4722 23847180 SGTC_1843 st055809 45.5 µM -2.23409277194008 0.0209109102302869 no 3281 0.0127384847534177 4743 16413835 SGTC_36 0335-0881 14.2 µM -2.24726137680096 0.0202853047460572 no 3282 0.0123116638489939 4678 23828853 SGTC_578 3460-0051 92 µM -2.27858381762492 0.0188607305916205 no 3283 0.0113459083987544 4759 2876744 SGTC_1174 0739-0097 51.1 µM -2.28748128375641 0.0184719323349359 no 3284 0.0110838733265911 4760 728447 SGTC_1471 k673-0312 37 µM -2.30492655408723 0.0177294002401069 no 3285 0.0105853435722318 4755 24099884 SGTC_2940 9060638 45.86 µM -2.31754608072475 0.0172082778929863 no 3286 0.0102370017499614 4700 4027022 SGTC_1612 st002233 45.4 µM -2.33190456199743 0.0166313162359102 no 3287 0.00985285621937773 4758 1035021 SGTC_1650 st011916 45.8 µM -2.33600761944194 0.0164695169441921 no 3288 0.00974542221323724 4741 242528 SGTC_1737 st035557 69.7 µM -2.3720665709027 0.0151046387484861 no 3289 0.00884445165775542 4665 5716916 SGTC_2549 cedrol 20.94 µM -2.37387322533885 0.0150388900239151 no 3290 0.00880129653785667 4737 6708665 A sedative which affects the nervous system. SGTC_2299 7976368 114.88 µM -2.38181328262635 0.0147528393083294 no 3291 0.00861381503455647 4734 2979718 SGTC_1527 coumarin 137 µM -2.39173957847981 0.0144018246769239 no 3292 0.00838436792449598 4750 323 A hepatotoxic, DNA x-linker. SGTC_1206 3978-0017 132 µM -2.39624329718442 0.0142449501780706 no 3293 0.00828204572263234 4732 3873677 SGTC_3352 9151559 45.5865 µM -2.4006810597921 0.0140918150596932 no 3294 0.00818229636987841 4756 17159339 SGTC_937 3122-0005 46.7 µM -2.44370979774456 0.0126791239511848 no 3295 0.00726855733198846 4738 759535 SGTC_1531 st059297 52.4 µM -2.45902585060348 0.0122067336390848 no 3296 0.00696572930220864 4763 7566702 SGTC_971 1315-0384 26.7 µM -2.48785484673111 0.0113588268400868 no 3297 0.00642580871174397 4770 6769120 SGTC_1912 st060209 90.8 µM -2.48995940024592 0.0112989832190491 no 3298 0.00638788442540268 4739 688787 SGTC_2614 arthonioic acid 13.39 µM -2.50129166457868 0.0109814348304082 no 3299 0.00618706116308204 4681 6710684 SGTC_244 nsc-207895 1.295 µM -2.50674959294342 0.0108312849479242 no 3300 0.00609234989977645 4721 42640 SGTC_3228 9131799 49.47 µM -2.51811584603826 0.0105243204649174 no 3301 0.00589922541749343 4772 17015818 SGTC_2929 9013348 24.6 µM -2.52492099493587 0.0103441870851523 no 3302 0.00578621511030492 4744 2995952 SGTC_2278 7948257 134.34 µM -2.52989780714603 0.0102141574308397 no 3303 0.00570478763638404 4760 1247028 SGTC_2363 9053361 176 µM -2.53083925529995 0.0101897211236693 no 3304 0.00568949917335655 4750 6469797 YMR079W SEC14 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.53690687608991 0.0100334495047022 no 3305 0.00559183495320334 4767 368090 SGTC_2759 disulfiram 3.38 µM -2.57287302338572 0.00914940132546263 no 3306 0.00504291015945039 4722 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_775 4577-0580 57.3 µM -2.60775579046688 0.00835789689581952 no 3307 0.0045568974576897 4762 2006902 SGTC_2217 6934799 96.0675 µM -2.62725146673155 0.00794225739114925 no 3308 0.00430388480551363 4778 675606 SGTC_2026 5148700 152 µM -2.63616506205518 0.00775835605647832 no 3309 0.0041924466425807 4766 79838 SGTC_737 1950-0117 57.9 µM -2.65413132769515 0.00739903840703816 no 3310 0.00397564371375875 4776 5393513 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.67064412526537 0.0070818070919502 no 3311 0.00378529315794894 4747 115019 SGTC_322 k048-0136 19.3 µM -2.67456199923044 0.0070083249327219 no 3312 0.00374134695343599 4786 6823282 SGTC_2113 5491891 107.031 µM -2.68843660453137 0.00675348133219306 no 3313 0.00358937327192464 4770 789979 SGTC_3339 9145883 14.936 µM -2.69018541416359 0.00672194805837367 no 3314 0.003570616477918 4753 2030670 SGTC_2231 micatex 6.853 µM -2.69791882002545 0.00658405942681433 no 3315 0.00348872267646903 4779 20737 An antifungal of unknown mechanism. SGTC_1229 0139-0193 12.2 µM -2.71189693574644 0.00634116085238697 no 3316 0.00334496949686477 4791 3090752 SGTC_2592 piperlongumine 83.33 µM -2.73920683076839 0.00588937757552612 no 3317 0.00307938074546548 4756 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_344 k064-0035 6.43 µM -2.76132824180896 0.00554459908166709 no 3318 0.00287833936064768 4751 5088750 SGTC_1952 st077036 64.1 µM -2.76976886001473 0.0054178475014356 no 3319 0.00280480427557003 4770 2937007 SGTC_1510 1123-0200 71.5 µM -2.77178667165406 0.00538793042699926 no 3320 0.00278747795540741 4777 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1732 st034308 51.822 µM -2.77903922113564 0.00528160950641829 no 3321 0.00272599709064764 4740 830119 SGTC_378 3970-0959 8.33 µM -2.84805533759134 0.00435953929557235 no 3322 0.00219936376292244 4782 6615653 SGTC_566 0958-0068 16.5 µM -2.84867767641019 0.00435192432803451 no 3323 0.00219506661997195 4765 6815365 SGTC_457 grayanotoxin iii 135 µM -2.84974997163677 0.00433883155477163 no 3324 0.00218768045389196 4662 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.86130722328229 0.00419993552600967 no 3325 0.00210948997686203 4789 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2016 5121758 140 µM -2.89227153616888 0.0038472006395641 no 3326 0.0019123361719062 4746 2795203 SGTC_1855 st056195 39.6 µM -2.91757065549163 0.00357896601221112 no 3327 0.00176384857885999 4764 4028379 SGTC_164 4100-3994 89.624 µM -2.96965159191613 0.00307898044413689 no 3328 0.00149068836468519 4767 4615967 SGTC_1627 st003713 25.6 µM -2.97706347493502 0.00301318561592147 no 3329 0.00145511875160415 4779 16195070 YER133W GLC7 SGTC_3273 9137859 49.47 µM -3.02050110129263 0.00265242557031894 no 3330 0.0012617839520857 4798 2377234 SGTC_171 k064-0041 9.68 µM -3.05605699420413 0.00238668171686196 no 3331 0.00112134310508475 4767 53325 SGTC_3259 9138485 49.47 µM -3.06800260191768 0.0023029613945403 no 3332 0.00107747370852643 4781 17646153 SGTC_3264 9137442 49.47 µM -3.12465884205836 0.001940978088789 no 3333 0.000890056916234207 4778 17015726 SGTC_396 dithiazanine 1.25 µM -3.13295830834207 0.00189252809020681 no 3334 0.000865270106871836 4794 10578 An antihelmenthic. SGTC_184 1494-0393 24.714 µM -3.23052875717898 0.00139982714338044 no 3335 0.000617807369473364 4774 3090647 SGTC_953 1188-0045 9.7 µM -3.23725450629999 0.00137061981201456 no 3336 0.000603428635002278 4779 6144426 SGTC_304 1310-0298 97 µM -3.27470477606825 0.00121792605534157 no 3337 0.000528862240192272 4690 1550234 SGTC_1240 0356-0016 42.1 µM -3.35097186607073 0.000954006631480459 yes 3338 0.00040264241643338 4786 4305613 SGTC_2885 9057732 51.95 µM -3.36412025762313 0.000914212486679268 yes 3339 0.000383940380305133 4797 6471414 SGTC_1249 0481-0015 10.2 µM -3.41307451489871 0.000779089875456359 yes 3340 0.000321171880737598 4788 4227577 SGTC_420 mitomycin C 81.9 mM -3.41308106278144 0.000779073102256514 yes 3341 0.000321164163870242 4804 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1909 st060837 51.5 µM -3.41774190550545 0.000767217789631116 yes 3342 0.000315714767362705 4789 678937 SGTC_926 2268-1401 59.4 µM -3.43166955496994 0.000732774446723882 yes 3343 0.000299939003616598 4797 2931578 SGTC_2986 9022445 71.43 µM -3.48915093012081 0.000605169662494419 yes 3344 0.000242278734794868 4795 6459286 SGTC_2604 4'-hydroxychalcone 11.32 µM -3.65374729922303 0.000344451344921532 yes 3345 0.000129220316152304 4797 5282362 SGTC_305 1682-2595 20.8 µM -3.67042314095298 0.000324912743386071 yes 3346 0.00012107463773104 4803 226033 SGTC_183 3914-0051 30.55 µM -3.74038983822716 0.000253643813405257 yes 3347 9.18675308744369e-05 4793 1596232 SGTC_381 3461-2219 42.7 µM -3.74717943222747 0.000247565812054338 yes 3348 8.94170820662904e-05 4806 2883159 SGTC_922 1866-0035 480 µM -3.96571445585902 0.000111019841696858 yes 3349 3.65882121037564e-05 4798 3156169 SGTC_1683 st010134 710 nM -4.02368102089732 8.91250937331185e-05 yes 3350 2.86477536203206e-05 4803 3818134 SGTC_1522 st012842 45.6 µM -4.09532010157402 6.76621209530844e-05 yes 3351 2.1079274277738e-05 4790 3491067 YOR116C RPO31 SGTC_2023 5144124 124 µM -4.20935579412676 4.32391803940165e-05 yes 3352 1.28049917019819e-05 4804 2830192 SGTC_453 enantio-paf c16 10 µM -4.48954764883275 1.3712722975134e-05 yes 3353 3.56872904403634e-06 4619 13871343 A lipid and platelet activating factor SGTC_2924 9010168 62.78 µM -4.63357367545436 7.3983570256715e-06 yes 3354 1.79703383506972e-06 4803 2993929 SGTC_313 3474-0040 5.03 µM -4.84550859336806 2.88668138008175e-06 yes 3355 6.31438725922426e-07 4809 1043375 YIL048W NEO1 SGTC_2983 9022671 12.99 µM -5.2182061565489 5.01087491964231e-07 yes 3356 9.03321568478014e-08 4807 6405161