SGTCid condition conc unit RPL36B|YPL249C-A.score RPL36B|YPL249C-A.strain.pval RPL36B|YPL249C-A.strain.significant RPL36B|YPL249C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_800 3448-7362 155 µM 5.90169801888615 3.10520853598361e-10 yes 1 1.79889628136125e-09 53 15991913
SGTC_830 4076-0286 57.8 µM 5.47452509028349 4.57486580986475e-09 yes 2 2.19343242909179e-08 23 6866659
SGTC_741 4582-0002 126 µM 5.4481164228702 5.36936201911194e-09 yes 3 2.5453017159677e-08 3 2912688
SGTC_422 cantharidin 155 µM 5.30542164446477 1.25979679649657e-08 yes 4 5.62064240598956e-08 27 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_832 4083-0019 164 µM 5.22154645104166 2.05950183899911e-08 yes 5 8.87175541996702e-08 33 1990758
SGTC_2344 7990960 76.95 µM 5.15643975969472 3.00119141855562e-08 yes 6 1.2584470195853e-07 12 140813
SGTC_2688 kanamycin b 96.69 µM 4.92718591754613 1.09164236413445e-07 yes 7 4.17111847053402e-07 251 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1383 3049-0032 20.7 µM 4.70258925497447 3.67109612262444e-07 yes 8 1.28441432117403e-06 9 712864
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 4.66855135907825 4.3920260395013e-07 yes 9 1.51665477206928e-06 5 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1186 1319-0216 26 µM 4.63123148074894 5.33889684888748e-07 yes 10 1.81748599049235e-06 10 4565136
SGTC_2937 9044753 11.33 µM 4.50331938205769 1.03126138816153e-06 yes 11 3.34501136761514e-06 22 6465530 YGL099W LSG1
SGTC_1021 4476-0760 85.3 µM 4.2429580748396 3.74091557000263e-06 yes 12 1.10296329425804e-05 16 746768
SGTC_1327 1436-0082 2.18 µM 4.14311820739156 6.02047058446883e-06 yes 13 1.71307616751216e-05 16 15992205
SGTC_659 k018-0002 107 µM 4.05180427054556 9.2212769172126e-06 yes 14 2.54120876130818e-05 14 6797879 YHR007C ERG11
SGTC_1619 st003326 88.7 µM 4.04816186480141 9.37779646298949e-06 yes 15 2.58107215310702e-05 17 2849032
SGTC_3232 9132874 49.47 µM 3.97096533287427 1.33551991522447e-05 yes 16 3.5790997966564e-05 12 3784940
SGTC_2940 9060638 45.86 µM 3.81178968381832 2.7164588030374e-05 yes 17 6.8982121784569e-05 31 4027022
SGTC_1921 5740136 50 µM 3.77948051632698 3.1277790080458e-05 yes 18 7.85779446446252e-05 67 1774243
SGTC_118 0083-0097 135.343 µM 3.77662218785241 3.16687713286445e-05 yes 19 7.94847950820039e-05 155 5207356
SGTC_3286 9117135 37.221 µM 3.7747753161934 3.19238543309702e-05 yes 20 8.00759727461121e-05 16 3438150
SGTC_2245 6637752 200 µM 3.69034451741621 4.5898655346551e-05 yes 21 0.000111975269703768 21 681890
SGTC_904 1141-0088 396 µM 3.68365649884421 4.72234194006116e-05 yes 22 0.000114956009419982 15 1378119
SGTC_1990 st072050 59.8 µM 3.66242751921217 5.16717082151627e-05 yes 23 0.00012491822705014 18 17233948
SGTC_3108 9121785 49.47 µM 3.58983216223943 7.00580533508872e-05 yes 24 0.000165445472290091 24 17140271
SGTC_1927 st060202 13.8 µM 3.58890463618247 7.03286582384617e-05 yes 25 0.000166035137719331 29 688887
SGTC_1781 st038725 66.3 µM 3.52380369367203 9.1983208706017e-05 yes 26 0.000212699644345817 120 4270275 YIL048W NEO1
SGTC_2376 9072922 81.32 µM 3.51064192309987 9.70628398870043e-05 yes 27 0.000223513055480672 45 17087968
SGTC_2489 cantharidin 73.42 µM 3.41429615240346 0.000143100899623884 yes 28 0.000319735127595401 66 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2998 9066762 71.4286 µM 3.3891311684988 0.000158129386761855 yes 29 0.000350572312285964 44 4945196
SGTC_2732 terfenadine 20 µM 3.38453102256894 0.000161031530269012 yes 30 0.000356499806542313 10 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3006 9075424 71.4286 µM 3.23530268358096 0.000287181687139729 yes 31 0.000607569200371818 33 7465181
SGTC_1398 3558-0053 112 µM 3.17575775182213 0.000359516699985923 yes 32 0.00074722846031316 13 4532369
SGTC_181 1447-1644 8.07 µM 3.17351141476886 0.000362551445074806 yes 33 0.000753034897715753 63 534600
SGTC_1659 st012954 42.1 µM 3.15310876477013 0.000391225110573418 yes 34 0.000807708028793049 32 24207262
SGTC_1335 1486-0900 202 µM 3.0965224489551 0.000482136991800659 yes 35 0.000979025176375242 68 X1335
SGTC_3154 9100113 49.47 µM 3.08716955191822 0.000498926076424579 yes 36 0.00101036150982117 67 25237525
SGTC_2754 granisetron 64.02 µM 3.0551254352298 0.000560637910658258 yes 37 0.00112483206066824 86 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1207 2099-0101 141 µM 3.02044421533774 0.000635329424687129 yes 38 0.00126202099416599 66 5837381
SGTC_2170 morpholine 200 µM 3.0147404284017 0.000648459013696705 yes 39 0.00128599634735258 35 121171 Reacts with secondary amines.
SGTC_148 3253-0744 288.01 µM 2.99394668206259 0.000698473808091324 yes 40 0.00137697032635112 67 6893655
SGTC_791 1348-1292 225 µM 2.97574605517218 0.000745145968034884 yes 41 0.00146138388418266 103 5437054
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.96970665607439 0.000761256957469861 yes 42 0.00149042121243636 50 66535 A nucleotide analog.
SGTC_33 0986-0033 35.816 µM 2.95618300226793 0.000798503573186027 yes 43 0.00155736111762968 51 2848082
SGTC_2314 7727897 200 µM 2.95066468369785 0.000814178356341187 yes 44 0.0015854547671026 72 900724
SGTC_2803 7707263 71.43 µM 2.92022725873577 0.000905841815640746 yes 45 0.00174888107072859 78 2199229
SGTC_556 4058-0063 51.5 µM 2.91409104924044 0.000925433067794775 yes 46 0.00178362924279941 72 6615692
SGTC_177 1327-0068 8.361 µM 2.90617601973491 0.000951278503867706 yes 47 0.00182937783724045 101 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1432 4049-0298 68.4 µM 2.89713397342188 0.000981614316282612 yes 48 0.00188294448721608 40 741646
SGTC_3224 9130643 49.47 µM 2.88185128952477 0.00103491309438467 no 49 0.00197673135519675 84 17644395
SGTC_831 k061-1017 217 µM 2.85237314229237 0.00114528625400242 no 50 0.00216970644886724 149 1240153
SGTC_402 epigallocatechin gallate 10 µM 2.81701831738698 0.00129183816690921 no 51 0.00242358805689317 100 65064 An antioxidant.
SGTC_557 1315-0110 16.2 µM 2.81576196505545 0.00129734829769943 no 52 0.00243308531403821 81 6833801
SGTC_375 3970-0961 9.27 µM 2.76556248617436 0.00153590439477049 no 53 0.00284123585526929 89 2898222
SGTC_1425 4048-4433 7.33 µM 2.70763564418416 0.0018604662734838 no 54 0.00338821862911765 118 23734946
SGTC_553 k007-0256 45.7 µM 2.66916213737193 0.00210926218791531 no 55 0.0038020366608925 110 6287000
SGTC_1839 st053978 48 µM 2.66855201636543 0.0021134399544498 no 56 0.00380894908109045 91 3788398
SGTC_2498 4'-Methoxychalcone 54.63 µM 2.65366376389055 0.00221774092463338 no 57 0.00398115617522167 97 641818 YHR062C RPP1
SGTC_2405 ticlatone 3.52 µM 2.65213305750325 0.00222872465655222 no 58 0.00399925074111685 159 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1396 3511-0007 98.6 µM 2.64515917924218 0.00227939290247661 no 59 0.00408262480674556 81 X1396
SGTC_793 0488-0545 106 µM 2.64273833828524 0.00229722385123112 no 60 0.00411192812239601 94 292548
SGTC_3234 9132280 49.47 µM 2.63603575683048 0.0023472533802377 no 61 0.00419404459724901 101 17612295
SGTC_1205 4161-2785 76 µM 2.62216082344404 0.00245396598474945 no 62 0.00436870946870936 118 3498106
SGTC_1022 4477-0945 21.3 µM 2.61274179865684 0.00252888856349964 no 63 0.00449095654950273 102 4648966
SGTC_625 k213-0058 121 µM 2.59784066414405 0.00265164876114197 no 64 0.00469060068148135 262 3655420
SGTC_698 k064-0052 127 µM 2.59515887266777 0.00267430524289623 no 65 0.00472736022851836 32 5088751
SGTC_563 tetrahydrosecaminediol 614 µM 2.5949285895099 0.00267625886258719 no 66 0.00473052868694613 108 334274 A psychoactive constituent of the cannabis plant.
SGTC_1015 4130-4525 82 µM 2.58453686084964 0.00276577022418383 no 67 0.00487549404407415 102 1363237
SGTC_889 0919-1524 82.7 µM 2.58032125247479 0.00280284617104081 no 68 0.00493542211012583 85 3905452
SGTC_544 k015-0020 52.4 µM 2.56232317462866 0.00296623313603778 no 69 0.00519872590732109 101 3008304
SGTC_2308 7584454 197.62 µM 2.54930527564014 0.00308970697084132 no 70 0.00539688850365805 136 893577
SGTC_105 0111-0055 734.78 µM 2.53617912204072 0.00321887474134997 no 71 0.00560346974079087 64 5179370
SGTC_665 3914-0008 307 µM 2.52507003878532 0.00333196735827963 no 72 0.00578376164644611 118 1069549
SGTC_433 pimozide 108 µM 2.51943021078813 0.00339073819581378 no 73 0.00587724698096043 80 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2936 9038235 15.59 µM 2.5071065266068 0.00352241297276457 no 74 0.00608620103611624 132 4749415
SGTC_228 caffeine 993.056 µM 2.50691317532205 0.00352451496123182 no 75 0.00608953119808246 72 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2232 chlorophetanol 41.5365 µM 2.48322073648408 0.00379076950971047 no 76 0.00651001895256248 259 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2624 nerol 100 µM 2.45477040760463 0.0041342270135903 no 77 0.00704872968391103 94 637566 A natural product oil.
SGTC_325 2810-4341 181 µM 2.44121004757164 0.00430752391634883 no 78 0.00731906896153413 73 774970
SGTC_3274 9138298 49.47 µM 2.42620420452779 0.00450683733720192 no 79 0.00762884122918426 125 17015756
SGTC_1331 1472-0049 76.2 µM 2.4128447496171 0.00469116949017478 no 80 0.00791428009104636 148 24051409
SGTC_231 b-estradiol 524 µM 2.41095923284709 0.00471772016778858 no 81 0.0079553133849494 79 450 A steroid.
SGTC_91 0417-1751 58.384 µM 2.40464303748609 0.00480764013616911 no 82 0.00809413483761715 184 6795624
SGTC_1606 st000094 49.2 µM 2.4023255395156 0.00484101423061634 no 83 0.00814560167134476 128 1242210
SGTC_581 0958-0271 211 µM 2.40190173921991 0.00484713963076497 no 84 0.00815504443670354 201 4591145
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.40021782485357 0.00487154641376793 no 85 0.0081926591142122 160 442882
SGTC_3237 9133362 49.47 µM 2.39872070611124 0.00489333768423903 no 86 0.00822622912843158 145 43845137
SGTC_899 1083-0020 478 µM 2.39729756283982 0.00491413269822336 no 87 0.00825825234760485 129 767123
SGTC_1328 1441-0025 69.2 µM 2.3703152276357 0.00532358197841571 no 88 0.008886462480555 99 4562601
SGTC_854 0422-0053 192 µM 2.36945424692526 0.00533713247952132 no 89 0.0089071795273054 116 3596728
SGTC_2878 9043973 25.97 µM 2.35269951043507 0.00560700243786695 no 90 0.00931884424805805 100 6465167
SGTC_3298 9116858 71.43 µM 2.34162005822886 0.00579205165983196 no 91 0.00960012478471802 120 2506942
SGTC_2819 7996655 46.38 µM 2.33714693198541 0.00586828442753757 no 92 0.00971577271054332 124 6456960
SGTC_2386 9075165 157.42 µM 2.30275863278542 0.00648467503912117 no 93 0.0106462136076696 101 16452277
SGTC_26 0302-0163 425.158 µM 2.28196515477824 0.00688457380999194 no 94 0.0112456987860719 117 3100915
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.25566740731586 0.00742141860669545 no 95 0.0120457341090426 181 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_269 exalamide 29 µM 2.24805575806004 0.00758353567888942 no 96 0.0122863173509412 115 3316 A derivative of salicylamide.
SGTC_3173 9105693 49.47 µM 2.24366997143535 0.00767835586034187 no 97 0.0124268217759234 179 17096658
SGTC_2001 4023502 57.655 µM 2.23959807709221 0.00776732240482869 no 98 0.0125585138346537 171 108941 YCR052W RSC6
SGTC_2237 6667747 47.222 µM 2.23710755249858 0.00782218368446267 no 99 0.0126396557358783 124 729940 YDL015C TSC13
SGTC_3231 9132313 49.47 µM 2.23590842546842 0.00784871942989193 no 100 0.0126788851493988 134 4905967
SGTC_3117 9124945 49.47 µM 2.23534488028528 0.00786121757510255 no 101 0.0126973578826672 112 17592065
SGTC_1074 carmofur 3.8 µM 2.2299936526382 0.00798077067169532 no 102 0.012873932133917 202 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1515 3460-0031 42.1 µM 2.22951534071722 0.00799153418586297 no 103 0.0128898178766094 128 2876596
SGTC_1516 st013856 110 µM 2.22224953653272 0.0081566140435819 no 104 0.013133223215027 133 5281404 A mutagen and neurotoxin.
SGTC_1340 1486-1359 257 µM 2.21143693084837 0.00840782434557914 no 105 0.013502797402808 164 4309068
SGTC_2944 9067346 25.62 µM 2.20363951358403 0.00859317298826813 no 106 0.0137748530458775 203 6473075
SGTC_691 1548-0686 185 µM 2.19968508206161 0.00868853446598272 no 107 0.013914622969798 213 46495133
SGTC_3141 9094609 49.47 µM 2.19615034363812 0.00877455920851369 no 108 0.0140405921032461 193 25236309 YDL196W YDL196W
SGTC_2755 lomerizine 42.69 µM 2.19215815099659 0.00887261402522176 no 109 0.0141840445304371 187 3949 A calcium channel blocker.
SGTC_840 0245-0196 390 µM 2.1680750593902 0.00948475016218827 no 110 0.0150764880522352 177 3827528
SGTC_1497 4476-2978 41.3 µM 2.16158958319469 0.00965578076303251 no 111 0.015324912548718 221 1528379
SGTC_1949 st076024 69.1 µM 2.16072508709087 0.00967878103155178 no 112 0.0153582909113856 191 2921930
SGTC_645 0845-0943 5.41 µM 2.15596346295599 0.00980632594616891 no 113 0.0155432591287034 158 1885106
SGTC_3019 9081971 49.47 µM 2.15396928550631 0.00986017664318916 no 114 0.0156212903462771 147 16451803
SGTC_3181 9108277 49.47 µM 2.14895477767908 0.00999673081862199 no 115 0.0158189924532404 166 17097298
SGTC_3221 9128209 49.47 µM 2.14736960935959 0.0100402398571154 no 116 0.0158819340534918 158 16460723
SGTC_1032 k061-1018 98.7 µM 2.14024380330363 0.0102378735218309 no 117 0.0161675344466336 216 4005393
SGTC_878 0828-0289 13.7 µM 2.13989605926931 0.0102476044056315 no 118 0.0161815838299818 251 745350 YLR208W SEC13
SGTC_2727 riluzole 51.77 µM 2.12107647858288 0.010786404513419 no 119 0.0169576835000229 139 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_264 promethazine 12.5 mM 2.12032466055185 0.010808431859014 no 120 0.0169893376864031 282 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3114 9122766 49.47 µM 2.11642778779182 0.0109232340323504 no 121 0.0171542204032142 192 17176985
SGTC_3179 9107801 49.47 µM 2.1073282666323 0.0111954462702645 no 122 0.0175445673982356 162 4818259
SGTC_3004 9076122 71.4286 µM 2.10319137064275 0.0113211392463665 no 123 0.0177245221583872 189 44782551
SGTC_3014 9081533 49.47 µM 2.09828473092684 0.0114718079931071 no 124 0.017940000267487 156 21367265
SGTC_2806 7952793 58.44 µM 2.09285870397278 0.0116404508443791 no 125 0.0181808847942184 196 2972490
SGTC_301 4119-0100 24.5 µM 2.08779769060808 0.0117996847618007 no 126 0.0184080439931553 266 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3277 9138724 49.47 µM 2.08664875364441 0.0118360957277317 no 127 0.0184599483989352 133 15943418
SGTC_1610 st001799 48.1 µM 2.07409025661763 0.0122404861619892 no 128 0.0190354646503106 154 621897
SGTC_735 3076-0345 636 µM 2.06497167475659 0.0125415620581016 no 129 0.019462840230239 240 2888990
SGTC_1704 st028805 70.8 µM 2.05806708671499 0.0127737820832382 no 130 0.0197918469735252 170 2876101
SGTC_805 3852-0218 479 µM 2.04656759423839 0.0131688007945569 no 131 0.0203502796749328 245 6615355
SGTC_2458 5808907 16.39 µM 2.03661494604714 0.0135191616250682 no 132 0.0208443219199787 161 2731747
SGTC_646 4092-0839 27.3 µM 2.02220895317844 0.014040531709852 no 133 0.0215773848658543 199 877796
SGTC_3178 9107506 49.47 µM 2.01596522588963 0.0142718283050744 no 134 0.0219018060854104 197 8897194
SGTC_1624 st003710 6.25 µM 2.0157182307198 0.0142810452389129 no 135 0.0219147240806473 271 24207033
SGTC_611 3453-1652 23.7 µM 2.01315816644733 0.014376879584473 no 136 0.0220489963121548 251 1560575
SGTC_3317 9138495 8.753 µM 2.01068693239409 0.0144699133783302 no 137 0.0221792675851267 218 17020139
SGTC_1675 st018485 24.5 µM 2.01043058867301 0.0144795934739473 no 138 0.0221928178678831 231 3323024
SGTC_594 1487-1584 10.8 µM 2.00837002554078 0.0145576075079927 no 139 0.0223019928348378 210 5013332
SGTC_468 gf-109203x 121 µM 2.00366452569285 0.0147371176307694 no 140 0.0225530043676883 112 2396 A protein kinase C inhibitor.
SGTC_1773 st048542 73.5835 µM 1.99937268331469 0.0149025042064402 no 141 0.0227840226358549 257 3237138
SGTC_2972 9093619 59.92 µM 1.97991100418139 0.0156726341464582 no 142 0.0238567648467684 220 25236256
SGTC_2071 5230951 39.92 µM 1.97508003187628 0.0158690104925021 no 143 0.0241295332422495 222 1799272
SGTC_103 0844-0104 51.839 µM 1.96796453388097 0.0161620921921842 no 144 0.0245360592885227 393 5375804
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.96749441709136 0.0161816182058227 no 145 0.0245631194611261 266 5379071
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.9533557574628 0.0167783755896495 no 146 0.0253887274154698 182 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2190 6049624 200 µM 1.95205568939162 0.0168341814276423 no 147 0.0254657966176826 163 2265554
SGTC_1057 3448-5381 134 µM 1.94976849440582 0.0169327453414916 no 148 0.0256018591439419 245 5497911
SGTC_368 fentichlor 4.58 µM 1.94358648482949 0.0172016241672319 no 149 0.0259726684595185 215 7329 A pesticide.
SGTC_3124 9127567 49.47 µM 1.93911414192166 0.0173984099440214 no 150 0.026243720530292 206 17592030
SGTC_1847 st056231 15 µM 1.93145127560841 0.0177400501363641 no 151 0.0267136346656277 293 5393180
SGTC_720 r052-1644 49.9 µM 1.92971780251526 0.0178181240396359 no 152 0.0268209064570219 209 1422863 YOR257W CDC31
SGTC_444 curcumin 90.4 µM 1.9289133736089 0.0178544541705087 no 153 0.0268708086432304 253 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2156 5649887 115 µM 1.92804585163716 0.0178937045426455 no 154 0.0269247116134797 269 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2112 5488546 200 µM 1.92392555123308 0.0180811306844121 no 155 0.0271819579865041 253 600757
SGTC_1347 1493-0251 600 nM 1.91897050401901 0.0183087422330622 no 156 0.0274940334206141 259 3986378
SGTC_2109 5483026 200 µM 1.91080255513178 0.0186892673933431 no 157 0.0280149796195824 282 759335
SGTC_857 0438-0306 1.35 µM 1.9099417389912 0.0187297600712981 no 158 0.0280703575761325 228 4686136
SGTC_99 0109-0120 622.8 µM 1.90360428293097 0.0190301776325644 no 159 0.0284808703041758 204 759414
SGTC_602 3130-1533 38.1 µM 1.90023558471156 0.0191915269898767 no 160 0.0287011051924349 280 720941
SGTC_2603 homopterocarpin 100 µM 1.89313009805881 0.019535672172485 no 161 0.0291702852266408 290 101795 A weak amylase inhibitor.
SGTC_2832 7992762 51.95 µM 1.88496365382038 0.0199376634949711 no 162 0.0297173725475384 242 2985177
SGTC_3325 9138760 55.175 µM 1.87894863844892 0.0202382206422491 no 163 0.0301257533238588 251 43844959
SGTC_2667 digitoxin 100 µM 1.87729999867772 0.0203212672020442 no 164 0.0302384942075402 146 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3119 9125183 49.47 µM 1.86590003986003 0.0209034557024221 no 165 0.0310276760177688 149 22695334
SGTC_2148 5546263 113.568 µM 1.86485617850208 0.0209574636685257 no 166 0.0311007831401201 257 792097
SGTC_1079 idarubicin 2.36 µM 1.86175559832479 0.0211185803210948 no 167 0.0313187738762317 223 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.84912067998814 0.0217860110254375 no 168 0.0322201944433179 154 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2646 retinol 96.75 µM 1.84341926136818 0.0220929688404216 no 169 0.0326339099809303 238 445354 A vitamin A analog and teratogen.
SGTC_799 1310-0557 151 µM 1.83989601326936 0.0222844753281805 no 170 0.0328917527239078 287 5354492
SGTC_974 1326-0144 138 µM 1.83067054433336 0.0227925718953084 no 171 0.0335748660769026 316 5411856
SGTC_1771 st048882 4.1505 µM 1.83065911132209 0.0227932075794949 no 172 0.0335757198408828 272 4580403
SGTC_1799 st045822 46.1415 µM 1.81776235826524 0.0235198533375925 no 173 0.0345502310815025 244 3674992
SGTC_1096 rimcazole 32.2 µM 1.81691874763347 0.0235680566566419 no 174 0.0346147777976995 242 18528119 A dopamine reuptake inhibitor.
SGTC_2845 9003024 42.97 µM 1.81589289729886 0.0236267849600862 no 175 0.0346934015349171 315 2990173
SGTC_2560 caryophyllene 100 µM 1.81571194403415 0.0236371570064831 no 176 0.0347072854508972 310 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1031 k035-0009 16 µM 1.81162951053859 0.0238721773694343 no 177 0.0350217309721249 307 5180959
SGTC_1617 st002906 78 µM 1.80714228130088 0.0241327641157578 no 178 0.0353700488163148 294 5150859
SGTC_1164 k060-0068 93.7 µM 1.80471448534445 0.0242747468453801 no 179 0.0355596859588832 304 5963676
SGTC_272 doxorubicin 8.13 µM 1.80358440658451 0.0243410751589962 no 180 0.0356482412028995 318 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_708 3448-5400 146 µM 1.79255881869926 0.0249962269261226 no 181 0.0365217481102383 325 3462195
SGTC_2785 7756463 72.73 µM 1.79220585505653 0.0250174422585246 no 182 0.0365499985581864 283 2201551
SGTC_2307 7538926 6.34 µM 1.79168685495904 0.0250486648407423 no 183 0.0365915706758051 340 96582
SGTC_2473 5854593 8.94 µM 1.79165335373997 0.0250506813659752 no 184 0.0365942554655402 250 2872951
SGTC_2150 5556613 200 µM 1.79143733322847 0.0250636874687545 no 185 0.0366115712325798 299 743190
SGTC_2378 9074213 121.43 µM 1.79075650050747 0.0251047158944532 no 186 0.0366661892635247 308 657714
SGTC_1636 st007707 68.9 µM 1.78946245435034 0.0251828530522819 no 187 0.0367701844687584 336 403051
SGTC_2196 6573537 42.6665 µM 1.7890114048657 0.0252101361998915 no 188 0.0368064894205822 241 2903087
SGTC_1607 st000305 50.6 µM 1.78215003830315 0.0256282310154251 no 189 0.0373623838554866 292 5457690
SGTC_2217 6934799 96.0675 µM 1.78124369012448 0.0256838906147747 no 190 0.0374363245405524 240 675606
SGTC_338 4055-0136 114 µM 1.78031941093968 0.0257407555477124 no 191 0.0375118510907571 300 2900563
SGTC_2623 humulene 100 µM 1.77516167446006 0.0260600158163348 no 192 0.0379355979463796 239 6187145 An anti-inflammatory.
SGTC_3054 9094397 49.47 µM 1.77221044342521 0.0262441800129654 no 193 0.0381798153409487 329 2598354
SGTC_3255 9139072 49.47 µM 1.77077432907652 0.0263341899597825 no 194 0.0382991182114138 281 17646060
SGTC_3275 9138069 49.47 µM 1.76572509603391 0.0266527068136747 no 195 0.0387209901652069 253 17617007
SGTC_2991 9074669 71.4286 µM 1.76521417782791 0.02668511520259 no 196 0.0387638883486564 356 17333109
SGTC_1992 st073643 23.3 µM 1.75505667933766 0.0273362845086358 no 197 0.0396248066415421 258 3161292
SGTC_1145 3546-0597 10.2 µM 1.74173314142517 0.0282104619256468 no 198 0.0407775752538181 334 875334
SGTC_3294 9122953 26.2835 µM 1.73870124193935 0.0284126066433362 no 199 0.0410436637382415 306 16459826
SGTC_3333 9141820 12.094 µM 1.73530487099589 0.0286404814465554 no 200 0.0413434097229137 261 1939433
SGTC_2394 5221648 200 µM 1.72460982337091 0.029368000668545 no 201 0.0422989059615709 365 788586
SGTC_3164 9100705 49.47 µM 1.72366091095309 0.0294332840543006 no 202 0.0423845377576831 227 17174235
SGTC_527 4476-4215 268 µM 1.72260016828398 0.0295064037273403 no 203 0.0424804272784915 332 4418754
SGTC_3097 9117246 49.47 µM 1.72108849618579 0.0296108676178379 no 204 0.0426173832322315 317 16423892
SGTC_1506 4226-2149 212 µM 1.71746957886101 0.0298621998555893 no 205 0.0429467040837857 372 991114
SGTC_376 3970-0862 59.1 µM 1.71429549168838 0.0300840930664939 no 206 0.0432372353533036 320 3135186
SGTC_3225 9130819 49.47 µM 1.7129068725321 0.0301815972182592 no 207 0.0433648368673397 326 4547121
SGTC_845 0330-0138 4.51 µM 1.71178388937021 0.0302606407595611 no 208 0.043468251056362 306 9039800
SGTC_282 k297-0036 65.7 µM 1.70949677538738 0.0304221546891902 no 209 0.0436794842582725 260 5061378
SGTC_2048 5246248 200 µM 1.70607915903288 0.0306648341957897 no 210 0.0439966711435839 248 677046
SGTC_1991 st073000 8.92 µM 1.70478975590539 0.0307568081820562 no 211 0.044116821382788 404 4301969 YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM 1.68372521358455 0.032291975339472 no 212 0.0461173931107009 312 5370536
SGTC_2026 5148700 152 µM 1.68083830056055 0.0325072162942483 no 213 0.0463971634919193 318 79838
SGTC_560 2332-1943 155 µM 1.6775317599466 0.0327551962209397 no 214 0.0467192721393237 303 21177716
SGTC_1903 st060211 78.3 µM 1.67143208359502 0.0332167443950109 no 215 0.0473181815795397 362 688960
SGTC_2194 5927483 104.545 µM 1.66827937986956 0.0334573941396151 no 216 0.0476301396578142 366 760979
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.66796373452236 0.033481566585508 no 217 0.0476614630750939 315 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.65950874939827 0.0341344271323624 no 218 0.048506659531832 360 688801
SGTC_2881 9058953 51.95 µM 1.65479200084795 0.0345031607328053 no 219 0.0489833485750556 381 17122249
SGTC_2065 5221596 34.26 µM 1.65115714821918 0.0347895439373805 no 220 0.0493532452816432 334 788581
SGTC_140 0062-0056 502.533 µM 1.65038908871571 0.0348503069950412 no 221 0.0494316906763168 383 3758964
SGTC_1443 4112-3303 14 µM 1.6477208840401 0.0350620725916702 no 222 0.0497049802443647 363 704433
SGTC_750 4073-0104 132 µM 1.64637303787005 0.0351694469564998 no 223 0.0498434902988328 269 22330957
SGTC_1139 k015-0024 46.9 µM 1.63986855845662 0.0356914163151891 no 224 0.0505162497538127 311 2766652
SGTC_2461 5755302 26.15 µM 1.63425528607424 0.0361469566589232 no 225 0.0511026291093524 383 2788904
SGTC_344 k064-0035 6.43 µM 1.63043690303848 0.0364595466848038 no 226 0.0515045952728713 355 5088750
SGTC_2416 tofa 880 nM 1.62995805426824 0.0364989030339174 no 227 0.0515551812497318 367 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_678 1218-2179 85.9 µM 1.62603698319467 0.0368224833797488 no 228 0.0519708940725345 271 6820081 YOR116C RPO31
SGTC_2505 galangin 7.89 µM 1.62174403151954 0.0371794387544504 no 229 0.0524290833395002 278 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1103 duloxetine 36.1 µM 1.62130531401289 0.0372160764599158 no 230 0.0524760879673048 416 60835 A selective serotonin reuptake inhibitor.
SGTC_1354 1498-1681 81 µM 1.60787940653182 0.038351626596561 no 231 0.0539307964500541 393 5754243
SGTC_2514 salinomycin 42.74 µM 1.59868104346664 0.0391458015280279 no 232 0.0549457458957261 434 23682228 A polyether potassium ionophore.
SGTC_188 3229-0966 278.469 µM 1.59350791697842 0.039598291744921 no 233 0.055523146849331 447 5722370
SGTC_2793 7325131 81.82 µM 1.58638531276005 0.0402282523374949 no 234 0.0563259650402538 349 4176441
SGTC_2086 5274770 176.623 µM 1.5834693682748 0.0404884913729979 no 235 0.0566572615320602 368 689278
SGTC_61 0978-8327 98.565 µM 1.58076789113814 0.0407308079507728 no 236 0.0569655593430702 401 6150059 YHR072W ERG7
SGTC_2452 5863136 48.41 µM 1.56858605977062 0.0418381486165579 no 237 0.0583722113763693 381 2184096
SGTC_3246 9135460 32.98 µM 1.56310762249053 0.0423440290803847 no 238 0.059013641523935 303 41446951
SGTC_254 nsc-64875 3.808 µM 1.553646005336 0.0432293615406895 no 239 0.0601344395594503 376 56993
SGTC_2121 5257820 149.641 µM 1.5466741715604 0.0438912411618252 no 240 0.0609709171436761 416 791256
SGTC_2276 7947513 42.08 µM 1.54571696877221 0.0439827491907822 no 241 0.0610864686552481 361 2105100
SGTC_1024 4507-0395 26 µM 1.54462025355971 0.0440877835863299 no 242 0.0612190721374952 398 4201836
SGTC_429 1112-0049 25.5 µM 1.53968627357915 0.0445628238512064 no 243 0.0618184221528424 384 2836170
SGTC_87 0100-0052 35.5 µM 1.53802678414344 0.0447235219049848 no 244 0.0620210330102536 641 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_537 1334-0398 209 µM 1.51748672194478 0.046751420790163 no 245 0.0645719216928493 432 5846986
SGTC_2652 actinonin 100 µM 1.51526090278063 0.046975534615416 no 246 0.0648531726217086 351 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_448 monastrol 171 µM 1.51141472844686 0.0473648290201665 no 247 0.0653414095728715 387 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2395 5646831 180.19 µM 1.51133771647792 0.0473726501841993 no 248 0.0653512145808638 413 6808628
SGTC_1410 3909-8106 77.9 µM 1.50740389926873 0.0477735383547673 no 249 0.0658535799624179 379 1039210
SGTC_3185 9108267 49.47 µM 1.50406663319349 0.048115758791054 no 250 0.0662821053223456 439 4910486
SGTC_3029 9088683 49.47 µM 1.50388739513197 0.048134194149396 no 251 0.0663051815484312 396 25236615
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.50268667714819 0.0482578386389386 no 252 0.0664599299469428 436 688751
SGTC_1929 genistein trimethyl ether 50.5 µM 1.50122306600725 0.0484088981549872 no 253 0.0666489379589791 403 136420
SGTC_912 3474-0017 2.18 µM 1.50120365748896 0.0484109038487225 no 254 0.0666514471307957 424 3360550
SGTC_2054 5233173 129 µM 1.50060114450486 0.0484732011455163 no 255 0.066729377575367 488 6889
SGTC_1217 1183-1422 255 µM 1.49796333754071 0.0487466943084232 no 256 0.0670713880502707 422 2849664
SGTC_1655 st012546 55.1 µM 1.49753319925047 0.0487914086480121 no 257 0.0671272868719487 389 720985 YLR208W SEC13
SGTC_1435 4092-0789 56.7 µM 1.49146583001312 0.0494256310643248 no 258 0.0679196179602908 409 2248285
SGTC_2698 st077697 67.5 µM 1.48771817371992 0.0498206502845119 no 259 0.0684126163704353 403 3154499
SGTC_1850 st056238 17 µM 1.48136328341897 0.0504962351225199 no 260 0.0692548966452059 481 5393177
SGTC_859 0439-0102 54.6 µM 1.48096574782191 0.0505387383019371 no 261 0.0693078505490282 461 610143
SGTC_2712 st079126 47.7 µM 1.47920688972196 0.050727131640124 no 262 0.0695425143687105 402 3152970
SGTC_1521 st012942 49.4 µM 1.4766515264238 0.0510018356010665 no 263 0.069884536039715 461 24207259
SGTC_3067 9117431 49.47 µM 1.47585865917753 0.051087309852608 no 264 0.069990919780049 375 17150885
SGTC_1574 spiramycin 23.7 µM 1.47209533955703 0.0514945665033628 no 265 0.0704975669206266 457 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2888 9058547 12.99 µM 1.47113103345137 0.0515993356502521 no 266 0.0706278419215407 351 16476514
SGTC_1232 0279-0259 161 µM 1.46970932126748 0.0517541097333809 no 267 0.0708202485527198 443 1560000
SGTC_637 1181-0519 7.26 µM 1.46688600438169 0.0520625627954669 no 268 0.0712035341939477 562 6252091 YGR060W ERG25
SGTC_879 0831-1030 162 µM 1.46615503148931 0.0521426605974909 no 269 0.0713030281255905 514 1549252
SGTC_3072 9116419 49.47 µM 1.46391223982982 0.0523890299450013 no 270 0.0716089643232069 390 17170162
SGTC_1874 staurosporine 7.6 µM 1.46164974481437 0.0526384992037474 no 271 0.0719186076469797 467 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_37 0566-0070 1.56 µM 1.46016140388263 0.0528031213992265 no 272 0.0721228600161101 498 1626686
SGTC_569 4130-2812 160 µM 1.45380867089389 0.0535103805557127 no 273 0.0729996794201589 330 743552
SGTC_1176 0848-0131 83.3 µM 1.4506934873769 0.0538599306603939 no 274 0.0734326148786349 502 6769040
SGTC_2926 9010726 65.15 µM 1.44876265417949 0.0540774925929639 no 275 0.0737019382537459 472 2994293
SGTC_926 2268-1401 59.4 µM 1.44829235566295 0.0541305899758248 no 276 0.073767652329497 462 2931578
SGTC_1086 cerivastatin 2.18 µM 1.44777668558556 0.0541888572882944 no 277 0.0738397575658981 419 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_905 2-aminofluorene 215 µM 1.44011064369741 0.0550609355891313 no 278 0.0749180491275692 485 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1463 k081-0032 34.1 µM 1.43778183993965 0.0553280417121682 no 279 0.0752479817870075 362 977755
SGTC_168 3970-0862 530.542 µM 1.4370081390141 0.0554170087674599 no 280 0.0753578404561047 660 3135186
SGTC_1553 gossypol 38.6 µM 1.43683944827994 0.0554364213281782 no 281 0.0753818092693402 302 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_647 0140-0236 81 µM 1.43417051267628 0.0557442716100232 no 282 0.075761804814243 521 990837
SGTC_3187 9109394 49.47 µM 1.4310390439431 0.0561071913387457 no 283 0.0762095127490849 489 17098090
SGTC_1583 clindamycin 39.6 µM 1.43001198437395 0.056226626741525 no 284 0.0763567897392786 442 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_209 4077-0173 175.592 µM 1.43000229420156 0.0562277545526834 no 285 0.0763581803089156 345 15993494
SGTC_3 0833-0587 95.581 µM 1.42671377835989 0.0566115266030938 no 286 0.0768312062475923 439 5382644
SGTC_441 propafenone 146 µM 1.42280920287898 0.0570698697856375 no 287 0.0773957364093954 407 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2964 9083345 53.42 µM 1.4182185863522 0.0576124754456283 no 288 0.0780634785698935 428 17741579
SGTC_782 0083-0095 30.5 µM 1.4163373837083 0.0578360000762081 no 289 0.078338373713122 523 3591729 An indicator and reagent.
SGTC_2462 5162487 171.77 µM 1.41231722502999 0.0583159605347391 no 290 0.0789282884021187 462 2259986
SGTC_2588 indole-3-carbinol 100 µM 1.40998248420033 0.058596134336556 no 291 0.0792724274917864 524 3712 Induces cell cycle arrest.
SGTC_1260 0700-1617 7.75 µM 1.4096333130378 0.0586381262987683 no 292 0.0793239925643684 516 2853078
SGTC_1376 2910-0861 41.3 µM 1.40793001610485 0.058843306685715 no 293 0.0795758969820944 507 1112859
SGTC_684 1140-0066 328 µM 1.40690078842745 0.0589675610081761 no 294 0.0797284048862158 520 6813534
SGTC_2710 st078562 53.7235 µM 1.40541117837509 0.059147759803767 no 295 0.079949522309432 451 17250908
SGTC_56 0957-0365 83.25 µM 1.40458032818063 0.0592484555890017 no 296 0.0800730548328172 490 6752360
SGTC_2098 5376439 882.5 nM 1.40342622760183 0.0593885510469795 no 297 0.0802448882527004 502 2844116
SGTC_1798 st045719 60.953 µM 1.4014173752724 0.0596330234986756 no 298 0.0805446497149028 418 3980186
SGTC_2451 5856223 45.7 µM 1.39709628093658 0.0601615623386951 no 299 0.0811923100237658 472 2179896
SGTC_1970 st070122 35.8 µM 1.395286080075 0.060384065867035 no 300 0.0814647939923538 492 102928
SGTC_2151 5563267 85.4165 µM 1.39499494595705 0.060419911088329 no 301 0.0815086818193412 503 5310824
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.39451001775342 0.0604796537253223 no 302 0.0815818232577811 460 140250 A respiratory chain inhibitor.
SGTC_1765 st044815 90.4 µM 1.39215319960926 0.0607706696585931 no 303 0.0819380056520532 473 645695
SGTC_2159 5658611 73.75 µM 1.38823639931565 0.0612567304330001 no 304 0.0825325359155157 450 793844
SGTC_3193 9111931 49.47 µM 1.38686164733595 0.0614280505705279 no 305 0.0827419773202054 487 17087244
SGTC_117 lucigenin 22.078 µM 1.38059358077859 0.0622139179967427 no 306 0.0837019790931198 554 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1180 1193-0155 285 µM 1.37646601464085 0.062735684916682 no 307 0.0843387010702537 463 2921347
SGTC_1944 st076371 56.9 µM 1.37341273844298 0.0631238400639077 no 308 0.0848120359478441 478 24208455
SGTC_220 paclitaxel 373.376 µM 1.37340504798145 0.0631248200884389 no 309 0.0848132306731281 428 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1006 4099-6547 255 µM 1.3703797343968 0.0635112672189679 no 310 0.0852841974085647 499 3146833
SGTC_385 1494-0393 12.4 µM 1.36221078301831 0.0645639511217229 no 311 0.0865656868918366 513 3090647
SGTC_835 0312-0010 67.2 µM 1.36052824361134 0.0647824437864555 no 312 0.0868314107319657 466 1626196
SGTC_695 3505-6186 243 µM 1.36002937458459 0.0648473365851617 no 313 0.0869103142524341 521 1819379
SGTC_2900 5328528 85.29 µM 1.35962675832213 0.0648997456330746 no 314 0.0869740330231786 552 795359
SGTC_1928 4'-methoxychalcone 40.3 µM 1.35746139394332 0.0651821779305537 no 315 0.0873173261087474 517 641818
SGTC_614 0462-0418 107 µM 1.35697245356113 0.0652460830811931 no 316 0.0873949816687453 459 5188303
SGTC_1629 st005085 44.9 µM 1.35539301240054 0.0654528502855452 no 317 0.0876461873671417 519 24207091
SGTC_2783 7738165 71.43 µM 1.34701505086627 0.0665581307958801 no 318 0.0889876926722097 416 17201110
SGTC_2861 9024595 19.48 µM 1.34570187459907 0.0667326765114671 no 319 0.089199340791942 374 16482810
SGTC_1738 st035555 74 µM 1.34521834177253 0.0667970362296391 no 320 0.089277367347879 515 5331140
SGTC_2146 5545642 200 µM 1.32845940564378 0.0690575123721147 no 321 0.0920131928170581 521 825326
SGTC_2928 9011484 9.79 µM 1.32832964141431 0.069075242399194 no 322 0.092034615807106 478 2994751
SGTC_566 0958-0068 16.5 µM 1.32808551859335 0.0691086070479753 no 323 0.0920749284542287 472 6815365
SGTC_300 r073-0011 5.04 µM 1.32643406997658 0.0693346393771106 no 324 0.0923479799492535 595 2735780
SGTC_3104 9120930 49.47 µM 1.32435006659268 0.0696206873188049 no 325 0.0926934049561856 455 17014836
SGTC_882 0843-0131 351 µM 1.32415987891374 0.069646837440341 no 326 0.0927249762164048 563 5425421
SGTC_2622 2-methoxyxanthone 59.94 µM 1.31914874138758 0.0703385786729185 no 327 0.0935596954405673 549 71034 A hepatoprotective.
SGTC_3017 9080681 49.47 µM 1.31109018339718 0.0714620509163899 no 328 0.0949136484538814 513 16451914
SGTC_721 1187-1332 279 µM 1.31021378895346 0.0715850577896015 no 329 0.095061761149835 436 25730
SGTC_2773 thioridazine 9.09 µM 1.31005875658778 0.0716068343518488 no 330 0.0950879796912179 553 5452 An antipsychotic.
SGTC_2531 methyl deoxycholate 70.07 µM 1.30728027156813 0.0719979755377997 no 331 0.0955587709689175 517 16667744 Haematoxylin.
SGTC_2742 clothiapine 36.27 µM 1.30718234171007 0.0720117914385682 no 332 0.0955753956118878 483 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1089 terbinafine 2.25 µM 1.30584972986068 0.0721999978064767 no 333 0.0958018323344383 521 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1777 st045864 34.765 µM 1.30372168120358 0.0725013260677885 no 334 0.0961642471467069 547 4691462
SGTC_1867 st057372 64 µM 1.30092510501263 0.0728987804509942 no 335 0.0966420459558418 553 688837
SGTC_2541 muurolladie-3-one 83.07 µM 1.29985319093301 0.0730515641952899 no 336 0.0968256454495519 536 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3356 9151811 4.48 µM 1.29717447284547 0.0734344427722248 no 337 0.0972855809299575 552 1859254 YPR165W RHO1
SGTC_1049 3226-0134 66 µM 1.29568215976741 0.0736484089551404 no 338 0.0975425050881147 580 5702385
SGTC_1770 st043884 66.3 µM 1.29528545662587 0.0737053679211249 no 339 0.0976108871521996 554 670149
SGTC_1258 0671-0043 57.1 µM 1.2936193004715 0.0739449637811799 no 340 0.0978984762199767 553 4298767
SGTC_2908 7930301 100 µM 1.29168066493256 0.0742244911641183 no 341 0.0982338780337399 604 2223178
SGTC_3131 9127911 49.47 µM 1.29141755482031 0.074262490517929 no 342 0.098279463299245 543 45595681
SGTC_463 ikarugamyin 104 µM 1.28839287477707 0.0747003939198889 no 343 0.0988046188901498 466 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1987 st072290 61.9 µM 1.28623445796582 0.0750140853582218 no 344 0.0991806243374281 574 54697379
SGTC_1748 st037455 53.6035 µM 1.28372879596966 0.0753795023303425 no 345 0.0996184325724187 563 580690
SGTC_1014 4130-3005 69.3 µM 1.2823626212952 0.0755793111816203 no 346 0.0998577350328735 583 743608
SGTC_1693 xanthone 101.9 µM 1.27923773524974 0.0760378559318483 no 347 0.100406675652724 578 7020 An insecticide.
SGTC_336 4111-0029 111 µM 1.27173277401287 0.077147780298644 no 348 0.101734040847317 502 3131175
SGTC_2393 9031399 185.94 µM 1.27131963099371 0.0772092365140289 no 349 0.101807480635034 554 1526623 YDL150W RPC53
SGTC_797 k781-0471 270 µM 1.27109133267493 0.0772432124993625 no 350 0.101848079210098 583 23738129
SGTC_2138 5575593 77.673 µM 1.26764696052017 0.0777571928580268 no 351 0.102462026865292 522 762213
SGTC_95 0471-0001 561.058 µM 1.26587224435603 0.0780230331008594 no 352 0.102779412447558 581 4015405
SGTC_1076 itraconazole 331 nM 1.26472918132982 0.0781946207966632 no 353 0.102984212747119 581 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1518 st038567 90.8 µM 1.26331589203074 0.0784071682706333 no 354 0.103237838592844 528 77966
SGTC_1426 4048-4480 71.7 µM 1.26212239159547 0.0785870021587973 no 355 0.103452374580089 591 14224343
SGTC_2332 7982454 138.89 µM 1.2619949197768 0.0786062277812552 no 356 0.103475307209284 595 2981748
SGTC_2203 7227154 166.4 µM 1.26023772943324 0.0788716150728531 no 357 0.103791808008705 530 896304
SGTC_2270 7924575 90.91 µM 1.25543720340762 0.079600095274917 no 358 0.104660045478002 616 1262135
SGTC_108 0509-0257 621.132 µM 1.25335765570399 0.0799172425643225 no 359 0.105037787247756 630 536624
SGTC_3080 9117754 49.47 µM 1.25212534016189 0.0801056306876463 no 360 0.105262097714759 635 9550191
SGTC_1002 4049-0206 172 µM 1.25125168286918 0.0802393927806619 no 361 0.105421333750833 635 4662749
SGTC_1756 st041558 35.5 µM 1.24621284454544 0.0810141650809043 no 362 0.106343132357253 641 3955792
SGTC_1913 st060213 96.1 µM 1.24473680158414 0.0812421874519327 no 363 0.106614256785602 635 688959
SGTC_2611 pyromycin 23.93 µM 1.24452708419324 0.0812746243038571 no 364 0.106652818811142 565 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2797 7859098 81.82 µM 1.24294381981526 0.0815198221532714 no 365 0.106944268280354 592 972681
SGTC_488 nitrendipine 139 µM 1.24139940208356 0.0817595409503614 no 366 0.107229119956678 617 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2411 st077133 39.94 µM 1.2391728608802 0.0821060711120881 no 367 0.107640744390199 660 1403142 YNL221C POP1
SGTC_3241 9133421 49.47 µM 1.237568393911 0.0823564691940075 no 368 0.107938069888517 535 17018221
SGTC_703 3875-0075 71.8 µM 1.23449850875902 0.0828371669471375 no 369 0.108508601032067 621 2850814
SGTC_78 0336-0123 156.75 µM 1.2337882204546 0.0829486875106879 no 370 0.108640914981806 545 6765896
SGTC_921 1561-0023 372 µM 1.23239559637706 0.0831676676099905 no 371 0.108900672546762 603 24050882
SGTC_1866 st057638 64 µM 1.23009816378337 0.0835298719874196 no 372 0.109330173798247 585 688802
SGTC_1182 1222-0449 220 µM 1.2297538813288 0.0835842522077347 no 373 0.10939464153338 566 658318
SGTC_460 trequinsin 123 µM 1.22944612459924 0.0836328856185434 no 374 0.109452292846101 634 5537 A vasodilator.
SGTC_2046 4110841 106 µM 1.22903314561422 0.0836981802318345 no 375 0.109529689468246 591 44119630 YMR134W ERG29
SGTC_2729 fluphenazine 10.66 µM 1.22775790413859 0.0839000457603156 no 376 0.109768931219166 596 3372 An atypical antipsychotic.
SGTC_2977 9011197 71.43 µM 1.22740153748471 0.0839565224607419 no 377 0.109835854413691 520 2704722
SGTC_274 sirtinol 40.1 µM 1.22383824921223 0.0845228001708457 no 378 0.110506626046552 596 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2480 5767542 37.17 µM 1.22165062763838 0.084871873664658 no 379 0.11091988722151 609 2867358
SGTC_31 0508-1974 57.237 µM 1.22063983884923 0.0850335273935511 no 380 0.111111207702287 588 6810525
SGTC_858 0438-0351 2.77 µM 1.21780181908972 0.0854886405727657 no 381 0.111649646445333 652 2799119
SGTC_1744 st037937 38.9 µM 1.21393907642637 0.0861110092295772 no 382 0.112385494784081 601 1016152
SGTC_1668 st014914 51.6 µM 1.21025794419676 0.0867072650798145 no 383 0.113089964953326 591 2839556
SGTC_1153 4055-0057 267 µM 1.20916017651611 0.0868856732220469 no 384 0.113300656984691 640 882706
SGTC_1362 1611-0397 101 µM 1.20767211291527 0.0871279495391341 no 385 0.113586704426306 612 27816
SGTC_1359 1582-0056 520 nM 1.20345962395881 0.087816533390918 no 386 0.114399253429084 675 3661189
SGTC_531 3788-1495 174 µM 1.20191388461232 0.0880702191641718 no 387 0.114698447195903 613 2896655
SGTC_1201 1889-3372 45.9 µM 1.20139903168639 0.0881548376927731 no 388 0.114798225785694 585 5392199
SGTC_784 4579-0127 173 µM 1.2010164157955 0.0882177616811343 no 389 0.114872416801481 647 1948547
SGTC_2866 9034245 58.44 µM 1.19736581347313 0.0888198143797181 no 390 0.115582001238087 581 6462273
SGTC_1986 st071812 45 µM 1.19386212948303 0.0894005095823214 no 391 0.116265951750407 581 11838594
SGTC_530 4358-1714 28 µM 1.19380448951848 0.0894100862969342 no 392 0.116277227548165 680 1564641
SGTC_214 4373-3496 70 µM 1.18920368153783 0.0901769608772728 no 393 0.117179763079244 799 3779166
SGTC_195 4234-0266 16.654 µM 1.18672217040492 0.0905926086409787 no 394 0.117668613520678 675 2303354
SGTC_2894 9048625 32.47 µM 1.1866209576647 0.0906095916913177 no 395 0.117688582727076 633 4092861
SGTC_1590 st077108 57.8 µM 1.18210255218356 0.0913701698690919 no 396 0.118582505928499 608 5489485
SGTC_3323 9138564 53.9225 µM 1.17245184087132 0.0930104945339333 no 397 0.120507848266138 709 43912313 YNL103W MET4
SGTC_134 0269-0018 6.916 µM 1.17118004998465 0.0932282730762125 no 398 0.120763206275823 652 4378915
SGTC_2057 5236571 38.335 µM 1.16923910897287 0.0935613612951544 no 399 0.121153654154433 678 54684039 YBR257W POP4
SGTC_981 1488-1094 54.9 µM 1.16554347498766 0.094198003685443 no 400 0.121899536487166 583 3449522
SGTC_3265 9137266 49.47 µM 1.15898023491302 0.0953365124075125 no 401 0.123232120843161 599 17224265
SGTC_954 1189-0853 2.85 µM 1.15801226968228 0.0955052764940821 no 402 0.123429514672107 673 2828194
SGTC_2000 st075254 36.4 µM 1.15645750798552 0.0957768081944785 no 403 0.12374703529499 619 17234175
SGTC_3245 9134821 49.47 µM 1.15484270334664 0.0960594268931228 no 404 0.124077423116652 667 17014901
SGTC_3013 9080133 71.4286 µM 1.15281762738025 0.0964147162124136 no 405 0.124492623805639 712 17050193
SGTC_100 0086-0128 49.5915 µM 1.15251715287639 0.0964675151026202 no 406 0.12455431266274 712 93297
SGTC_1394 3474-0001 65.7 µM 1.15094673730263 0.0967438116715525 no 407 0.124877074215436 581 5017666 YIL048W NEO1
SGTC_1210 3013-0140 750 nM 1.14800633037102 0.0972627044846858 no 408 0.125482975268817 707 905973
SGTC_383 2324-0395 7.37 µM 1.14765131682253 0.0973254915280067 no 409 0.125556268035118 663 3146421
SGTC_2775 cyproheptadine 69.59 µM 1.1400042134667 0.098685171206403 no 410 0.127142272866969 684 2913 A selective serotonin reuptake inhibitor.
SGTC_578 3460-0051 92 µM 1.13830798238605 0.098988641544521 no 411 0.127495950993425 754 2876744
SGTC_1447 4239-0816 81.9 µM 1.13747276859425 0.0991383190640024 no 412 0.127670351070289 633 1341554
SGTC_3045 9092950 49.47 µM 1.13673509386636 0.0992706543352328 no 413 0.127824521978026 720 44120432
SGTC_1784 st039334 36.3 µM 1.13600612944842 0.0994015538542703 no 414 0.127976999518731 672 3496984
SGTC_2092 5303694 80.6725 µM 1.13365017266261 0.0998254738052021 no 415 0.128470659147718 694 1963699
SGTC_2261 9010538 184.68 µM 1.13287181305899 0.0999658180358228 no 416 0.128634044227598 586 6457250
SGTC_1732 st034308 51.822 µM 1.13171592361126 0.100174499594547 no 417 0.12887694237077 644 830119
SGTC_1819 st053448 58.6 µM 1.12995546597943 0.100492939199981 no 418 0.129247495150799 672 2857616
SGTC_2804 7954240 19.48 µM 1.12903662497588 0.100659436393912 no 419 0.129441191924714 731 828705
SGTC_1609 st001574 46.4 µM 1.12355172776058 0.101657505599909 no 420 0.130601622209926 693 3960012
SGTC_1730 st033808 45.1 µM 1.12256931828467 0.101837029783607 no 421 0.130810226104225 770 1045166
SGTC_2080 5212524 12.4 µM 1.12173489275548 0.10198969273188 no 422 0.130987588008041 652 260183
SGTC_1320 1313-0481 95.3 µM 1.12093680781732 0.102135862711649 no 423 0.131157380908131 704 6813365 YLR208W SEC13
SGTC_860 0443-0016 25.1 µM 1.12050375827869 0.102215239882812 no 424 0.131249575974751 698 5337942
SGTC_2419 paclitaxel 166.5 µM 1.11933961219828 0.102428848123834 no 425 0.131497641347116 727 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_71 0417-1750 47.813 µM 1.11516788903733 0.103196979799327 no 426 0.13238924182069 733 6811472
SGTC_211 3455-0679 143.504 µM 1.11426860421256 0.103363110079319 no 427 0.132581985823585 721 748649
SGTC_3348 9149464 3.537 µM 1.11303104309255 0.103592049478132 no 428 0.132847548637619 699 1951442
SGTC_2189 6047310 154.431 µM 1.11174940981526 0.10382952951239 no 429 0.133122954539559 673 711535
SGTC_1722 st034304 3.6505 µM 1.10824138470204 0.104481567615442 no 430 0.133878791133428 705 4036148 YLR033W RSC58
SGTC_1209 2323-2347 50.3 µM 1.10775356520951 0.104572473270306 no 431 0.133984129500441 692 5412760
SGTC_3272 9137413 49.47 µM 1.10768984535394 0.104584351759275 no 432 0.133997893190879 671 17614870
SGTC_754 3474-0146 171 µM 1.10340441680321 0.105385474923834 no 433 0.134925789736168 653 24762078
SGTC_2638 epoxomicin 18 µM 1.10159117665239 0.105725777375762 no 434 0.135319722979932 750 9915668 A protesome inhibitor.
SGTC_1670 st016595 4.04 µM 1.10070441269485 0.10589249103383 no 435 0.135512662558319 711 597879
SGTC_297 0986-0032 24 µM 1.10019932807656 0.105987532985833 no 436 0.135622641651499 674 2847425
SGTC_1485 3909-9022 254 µM 1.09595922128241 0.106787826920922 no 437 0.13654831027204 726 714516
SGTC_2439 5492030 7.2 µM 1.09464032312282 0.107037647658019 no 438 0.136837121309658 693 5722370
SGTC_536 3852-0578 10.6 µM 1.09167997300731 0.107599920385545 no 439 0.13748689543689 725 2869208
SGTC_1060 3448-7350 82 µM 1.09053835110851 0.10781732145155 no 440 0.13773803457582 721 570178
SGTC_476 mead acid 10 µM 1.08688206489721 0.108515723329017 no 441 0.138544466775256 647 5312531 An omega 9 fatty acid.
SGTC_334 1502-1024 68.5 µM 1.08319829031152 0.109222661260426 no 442 0.139360209226499 732 3296216
SGTC_2256 7954252 200 µM 1.07847729168684 0.110133478144688 no 443 0.140410405220834 615 2972920
SGTC_2974 9094440 9.66 µM 1.07253017277697 0.111288586979627 no 444 0.141740984564549 751 25236134
SGTC_2296 7971656 126.45 µM 1.0718774279455 0.111415895854859 no 445 0.141887544910905 711 666570
SGTC_3295 9122362 53.5725 µM 1.07175909970114 0.111438985302525 no 446 0.141914124052722 691 4730473
SGTC_607 4491-0986 66.8 µM 1.07159309501098 0.111471383650113 no 447 0.141951418061088 750 698981 YDR232W HEM1
SGTC_3041 9091929 49.47 µM 1.06983398465506 0.111815115103882 no 448 0.142347021077303 757 25236887
SGTC_1524 corynanthine 62.1 µM 1.06888131450995 0.112001583676615 no 449 0.142561576331806 707 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3351 9150312 21.596 µM 1.06811062716769 0.112152594889403 no 450 0.142735306340407 727 4904905
SGTC_2292 7671323 168.05 µM 1.06573352005982 0.112619290259511 no 451 0.143272060222986 731 937504
SGTC_2860 9025725 38.96 µM 1.06528715938122 0.112707078312835 no 452 0.143373000865634 689 40546248
SGTC_1297 1068-0111 14.1 µM 1.06397915621031 0.112964611407343 no 453 0.143669071054932 720 767057
SGTC_1165 k072-0275 30.3 µM 1.06351605149142 0.113055892821906 no 454 0.143773994940595 726 6153523 YGL055W OLE1
SGTC_1162 k048-0130 20.1 µM 1.05994306224936 0.113761925846333 no 455 0.144585251663962 748 6797406
SGTC_2310 7668677 200 µM 1.05941408859872 0.113866719058053 no 456 0.144705618102881 712 2197143
SGTC_1109 tnp00067 928.257 nM 1.05449819552972 0.114843881420275 no 457 0.14582744316797 743 676295
SGTC_1958 st076513 41.9 µM 1.05395011108175 0.114953196049245 no 458 0.145952879280154 743 732122 YGL099W LSG1
SGTC_688 0527-0193 473 µM 1.05382172332899 0.114978813490526 no 459 0.145982272931395 727 4007154
SGTC_2643 anethole 100 µM 1.05093536587495 0.115555805620889 no 460 0.146644138054175 796 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2352 9027995 87.8 µM 1.04913660246056 0.115916423040887 no 461 0.147057626020644 693 2997347
SGTC_317 4495-0002 170 µM 1.04708256155078 0.116329195018045 no 462 0.147530750698633 701 15991618
SGTC_469 w7 172 µM 1.04393023458392 0.1169647007617 no 463 0.148258834293615 730 45115570 A P450 inhibitor.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.04318446079833 0.117115407177493 no 464 0.148431434472946 730 75037 A free radical scavenger.
SGTC_247 mechlorethamine 29.705 µM 1.04276286270805 0.117200664819503 no 465 0.148529067605177 714 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.04165758643988 0.117424387926407 no 466 0.148785229845301 682 61125 An anti-inflammatory.
SGTC_2808 7946468 45.46 µM 1.0401875795004 0.11772240585192 no 467 0.149126380425147 786 2970879
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.03888701388382 0.117986518505402 no 468 0.149428643309093 745 688662
SGTC_1292 0kpi-0043 232 µM 1.03771978239608 0.118223910967685 no 469 0.149700266145165 722 3333905
SGTC_2316 5844804 197.44 µM 1.03631545149765 0.11850997225726 no 470 0.150027499959364 905 776813
SGTC_568 1193-0097 7.48 µM 1.03498620918646 0.118781188372823 no 471 0.150337675847913 771 3646150
SGTC_3312 9133330 71.43 µM 1.03233626795349 0.119323185064069 no 472 0.150957308280308 819 17617324
SGTC_3035 9091303 49.47 µM 1.03143324938783 0.119508278980146 no 473 0.151168847730029 775 25237002
SGTC_2961 9083290 32.55 µM 1.02807751469325 0.120197886723544 no 474 0.151956683324882 731 17741490
SGTC_675 1309-0189 238 µM 1.02756554727389 0.120303342694444 no 475 0.152077118772694 745 4246530
SGTC_1764 st044502 93.5 µM 1.02691049883248 0.120438365776297 no 476 0.152231305083103 771 8407
SGTC_989 1501-0895 10.3 µM 1.02566097806096 0.120696221472972 no 477 0.152525706922796 791 2830112
SGTC_973 1325-0077 65.9 µM 1.02365935896719 0.121110092415441 no 478 0.152998098816131 843 2835149
SGTC_1648 st011736 69.8 µM 1.02352125298495 0.121138685096462 no 479 0.153030728234559 760 2855514
SGTC_2099 5377090 177.372 µM 1.02255898986847 0.121338038408826 no 480 0.153258204031734 766 2243829
SGTC_1451 4152-0210 104 µM 1.02188281509487 0.121478260354898 no 481 0.153418183464918 813 659563
SGTC_1198 1612-1005 86.7 µM 1.02137623014716 0.121583388174275 no 482 0.153538111283655 804 6998509
SGTC_538 2922-0838 53.3 µM 1.01944843731825 0.121984033339109 no 483 0.153995060300097 866 777039
SGTC_2834 9001755 58.44 µM 1.01451495726684 0.123013557959925 no 484 0.15516854799099 715 2989575
SGTC_335 4077-0256 27.6 µM 1.01426664864416 0.123065535831319 no 485 0.15522776681918 868 3121989
SGTC_246 cycloheximide 667 µM 1.01041517102596 0.123873728560824 no 486 0.156148211197986 696 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2358 9037157 4 µM 1.00998062976179 0.123965145228668 no 487 0.15625228522847 788 2388925
SGTC_443 clozapine 122 µM 1.00994112335756 0.123973458733674 no 488 0.156261749404931 718 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_106 0092-0003 11.579 µM 1.00964478852523 0.124035830205058 no 489 0.156332751583827 722 1072148
SGTC_2737 bleomycin 30.5 nM 1.00938078515201 0.124091415161033 no 490 0.156396025002442 839 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_990 3985-0011 41.3 µM 1.00837249016357 0.124303868411405 no 491 0.156637837225124 738 5399565 YGL099W LSG1
SGTC_520 3584-0023 682 µM 1.00648260338217 0.124702762847829 no 492 0.157091737965341 730 1340790
SGTC_3353 9151644 39.2805 µM 1.0037504414287 0.125281014700441 no 493 0.157749458654931 795 4909158
SGTC_2569 tetrandrine 100 µM 1.00353237686323 0.125327247788326 no 494 0.157802031756846 711 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1107 amlodipine 47 µM 1.00289266274812 0.125462945873635 no 495 0.157956326573843 778 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3198 9112019 49.47 µM 1.00096410478622 0.125872657841613 no 496 0.158422081253462 785 45595555
SGTC_397 arbidol 50 µM 1.00057076455187 0.12595633533558 no 497 0.158517185032974 853 131410 A RNA synthesis inhibitor.
SGTC_1898 st060199 18.6 µM 1.00036785495397 0.125999516605549 no 498 0.158566260173134 783 688866
SGTC_1344 1488-0097 29.1 µM 0.997960628619958 0.126512587060257 no 499 0.159149225283932 787 747966
SGTC_3327 9140648 26.9345 µM 0.997936961624743 0.126517638601143 no 500 0.159154963750571 790 8029710
SGTC_2792 7535235 81.82 µM 0.996303861247072 0.126866550912515 no 501 0.159551264134131 730 1281891
SGTC_1632 st005650 90 µM 0.994049471198228 0.127349301674474 no 502 0.160099391617233 777 2759605
SGTC_234 nsc-17383 10.7 µM 0.992107869810991 0.127766095341365 no 503 0.160572453973208 859 408974
SGTC_3163 9099914 49.47 µM 0.991099600386024 0.127982908995758 no 504 0.160818474058947 785 16268368
SGTC_356 1634-0012 32.5 µM 0.989913362025714 0.12823831938768 no 505 0.16110823390381 841 735457
SGTC_303 1348-1668 34.2 µM 0.989834206391829 0.128255375069975 no 506 0.16112758119416 809 5380509
SGTC_976 1348-1067 47.6 µM 0.989508218343568 0.128325632389592 no 507 0.161207275459595 871 5310671 YGL099W LSG1
SGTC_1090 efavirenz 20.7 µM 0.989081130790743 0.128417719222212 no 508 0.161311724418863 814 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2173 5763948 167 µM 0.988983150550737 0.128438851779617 no 509 0.161335692787915 821 2867177
SGTC_3125 9127534 49.47 µM 0.987692988721495 0.128717341428733 no 510 0.161651514652116 700 1639235
SGTC_744 1594-0068 283 µM 0.985755052401872 0.129136444142593 no 511 0.162126663561996 861 668392
SGTC_2045 5106652 78.05 µM 0.984276159727724 0.129456908785447 no 512 0.162489874036414 828 673349
SGTC_1468 k284-1086 134 µM 0.981671229028717 0.130022716377141 no 513 0.163130921926784 877 15996457
SGTC_828 2074-0507 139 µM 0.980848411675839 0.130201792758631 no 514 0.163333750325659 843 X828
SGTC_3123 9126162 49.47 µM 0.972223951122188 0.13208907476465 no 515 0.165469573817385 808 25239884
SGTC_3273 9137859 49.47 µM 0.971402728491908 0.132269760718729 no 516 0.165673885181283 837 2377234
SGTC_206 4546-0025 72.014 µM 0.970757791500056 0.132411779576404 no 517 0.165834452880419 875 6620745 YIL048W NEO1
SGTC_2321 7390090 138.78 µM 0.96983452146605 0.132615271821017 no 518 0.16606449120002 738 649046
SGTC_2108 5365811 200 µM 0.969784614631717 0.132626277612076 no 519 0.166076931660735 864 780283
SGTC_902 1120-0002 2.07 µM 0.967441580966552 0.133143687455563 no 520 0.166661665982272 839 3280475
SGTC_2781 5567276 71.43 µM 0.965932892258553 0.133477584021398 no 521 0.167038881051839 792 2853274
SGTC_3155 9099265 49.47 µM 0.965442807080732 0.133586171408993 no 522 0.167161534656846 781 25236499
SGTC_204 PMA1.184 62.41 µM 0.965177021009629 0.133645086601541 no 523 0.167228077206851 887 2252213 YGL008C PMA1
SGTC_2287 7945887 168.79 µM 0.960364491160849 0.134714941983673 no 524 0.168435901376305 891 1245853
SGTC_2700 st077718 96.8 µM 0.959969207157533 0.134803076535756 no 525 0.168535356425923 779 904970
SGTC_510 ag-490 170 µM 0.959142126785718 0.134987614590633 no 526 0.168743575298949 916 5328779
SGTC_2910 7948405 25.97 µM 0.958998380540536 0.135019704897875 no 527 0.168779780513248 803 2971328
SGTC_2282 7944268 200 µM 0.957020359125432 0.135461815216286 no 528 0.169278489541428 860 2970414
SGTC_3038 9091290 49.47 µM 0.957002891504927 0.135465723842302 no 529 0.169282897778054 828 25236843
SGTC_908 3448-7491 47.7 µM 0.955542078781158 0.13579287477387 no 530 0.169651818267922 903 1203031
SGTC_2114 5491910 81.25 µM 0.955089588219489 0.135894320299152 no 531 0.169766196890958 849 2849228
SGTC_1926 methyl fluorone black 53.6 µM 0.952146902871209 0.136555317757393 no 532 0.1705112424594 775 72721 Reacts with homocysteine.
SGTC_3023 9089636 49.47 µM 0.95056236448897 0.136912152228294 no 533 0.170913290682649 903 17249241
SGTC_642 0335-0876 158 µM 0.947538012519393 0.137594997122733 no 534 0.171682347938273 858 6812350
SGTC_2664 lyso-paf C-16 73.48 µM 0.944052712645693 0.138384794437938 no 535 0.172571356037476 904 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_772 k072-0172 35.3 µM 0.942993912256409 0.138625337935151 no 536 0.172842008393731 788 5861980
SGTC_2372 9071633 200 µM 0.942511036789785 0.138735134487625 no 537 0.172965531611797 936 21321366
SGTC_1684 st024538 14.6195 µM 0.942096281198328 0.138829489172332 no 538 0.173071674138618 872 6732859
SGTC_1558 st069300 45.6 µM 0.939207507642285 0.139487881832281 no 539 0.173812107582333 807 24208000
SGTC_2626 ethyl orsellinate 100 µM 0.936688721014681 0.140063679705986 no 540 0.174459349848619 836 75653 A natural product.
SGTC_1887 st057648 70.8 µM 0.936220725891315 0.140170841644422 no 541 0.174579777072205 878 688672
SGTC_2942 9052777 62.25 µM 0.935632757753773 0.14030555403303 no 542 0.17473115125307 924 6469503
SGTC_2387 9077560 195.08 µM 0.93017020840864 0.141561309425061 no 543 0.176141482086901 853 5303272
SGTC_577 r071-0003 38.6 µM 0.929920372971175 0.141618924251386 no 544 0.176206156897273 1009 4568517 YMR134W ERG29
SGTC_1806 st050005 60.3 µM 0.929780994890399 0.141651073286896 no 545 0.176242244181495 856 5194765
SGTC_2271 7849410 118.62 µM 0.920269542811133 0.143856675627624 no 546 0.17871596050268 882 972430
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.914075341121696 0.145305436093375 no 547 0.18033862932005 903 2724 A muscle relaxant with antifungal properties.
SGTC_1802 st050112 57.9 µM 0.91388969316356 0.145349008227277 no 548 0.180387404990288 920 4662563
SGTC_1999 st074831 12.5 µM 0.913436015329742 0.145455524760446 no 549 0.180506635525387 899 17112523
SGTC_2409 alverine citrate 63.97 µM 0.910118233161951 0.146236084309197 no 550 0.181380079898005 882 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1404 3909-7820 48.3 µM 0.907756811841468 0.146793355738029 no 551 0.18200336041636 909 23741373
SGTC_2540 epiandrosterone 100 µM 0.906604695509624 0.147065759922121 no 552 0.182307938904831 1077 441302 A steroid.
SGTC_1392 3455-1037 33.9 µM 0.903307054162624 0.147847320420693 no 553 0.18318147684705 886 981132
SGTC_1645 Cervolide 78 µM 0.901875918071804 0.148187371886737 no 554 0.183561392640701 868 23173 A fragrance.
SGTC_2093 5331342 194.4 µM 0.901783730832516 0.148209294372474 no 555 0.183585881901067 930 33839
SGTC_679 0422-0091 41.4 µM 0.900106813004344 0.148608450714289 no 556 0.184031705347914 946 627384 YHR062C RPP1
SGTC_1487 3970-0795 2.82 µM 0.898113411772718 0.149083873657526 no 557 0.184562544764409 939 3765103
SGTC_2702 st077768 96.8 µM 0.896488773426076 0.149472097847252 no 558 0.184995886798849 816 6484119
SGTC_516 3992-2719 87.3 µM 0.894752428450195 0.149887760808471 no 559 0.185459722735933 926 5350887 YDR037W KRS1
SGTC_2236 dapsone 200 µM 0.891699893418728 0.150620373250103 no 560 0.186276905346363 986 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2051 5263410 176 µM 0.891685697768282 0.150623785786419 no 561 0.186280710814657 959 227584
SGTC_2354 9060492 162 µM 0.891181880557508 0.150744933307118 no 562 0.186415801715259 974 6471895
SGTC_2905 7799065 20.05 µM 0.890810788146623 0.150834207399589 no 563 0.186515343285595 888 1296806
SGTC_1717 st033143 58.0435 µM 0.890354716407028 0.150943973257909 no 564 0.186637724730722 936 674616
SGTC_3027 9089541 49.47 µM 0.88794345972652 0.151525190066299 no 565 0.187285582836904 902 9943819
SGTC_2987 9018338 71.43 µM 0.88747140343864 0.151639149906504 no 566 0.187412577803839 934 5055682
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.886251246848574 0.151933973665576 no 567 0.187741077013014 960 688798
SGTC_2258 7960471 200 µM 0.885479966372453 0.152120532770307 no 568 0.187948909959401 821 2974708
SGTC_885 0865-0106 16.8 µM 0.885029439718362 0.152229577550865 no 569 0.188070376733504 941 2793380
SGTC_1572 epiandrosterone 68.9 µM 0.881135227080141 0.153174289403218 no 570 0.189122316268041 961 441302 A steroid.
SGTC_907 3448-6986 75.5 µM 0.879497377810393 0.153572779719938 no 571 0.189565827126378 991 590582
SGTC_2770 toltrazuril 17.5 µM 0.879353407485154 0.153607840635004 no 572 0.189604843217722 969 68591 Kills coccidiodes.
SGTC_1931 st074438 57.1 µM 0.876879334554361 0.154211176665591 no 573 0.190276090944523 933 2787313
SGTC_2136 5328288 199.296 µM 0.8768388721465 0.154221056977552 no 574 0.190287081033508 836 262395
SGTC_430 0958-0115 16.4 µM 0.876128763307816 0.154394523032588 no 575 0.190480018817224 881 6833180
SGTC_1947 st076332 61.6 µM 0.875750747998213 0.154486917560931 no 576 0.19058277519621 930 24208416
SGTC_1984 st072354 53.1 µM 0.874717469972704 0.154739657907791 no 577 0.190863826059272 937 5762938
SGTC_2596 sinensetin 100 µM 0.874607187700394 0.154766649135294 no 578 0.19089383776699 881 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2537 larixol 68.93 µM 0.870732016061871 0.155717059713949 no 579 0.191950246487364 979 6708759
SGTC_51 1013-0126 23.419 µM 0.869115577111057 0.156114636860102 no 580 0.192391958698751 923 1627850
SGTC_501 nsc-95397 161 µM 0.867455115673442 0.156523737577256 no 581 0.192846347187549 915 262093
SGTC_814 3342-0569 96 µM 0.867003113523837 0.156635222955482 no 582 0.192970151876119 951 4346283
SGTC_848 0368-0089 85.6 µM 0.863347623179582 0.15753876228422 no 583 0.193973183822297 970 762535
SGTC_3326 9140064 16.379 µM 0.863296652530257 0.15755138502639 no 584 0.193987192106362 977 1868434
SGTC_1922 5578187 25 µM 0.863083879990704 0.157604084742381 no 585 0.19404567512627 929 1350412
SGTC_141 0443-0274 32.331 µM 0.861376133739272 0.158027480528557 no 586 0.194515458152515 1092 1627241
SGTC_2544 sphondin 68.51 µM 0.860084298301366 0.158348256557645 no 587 0.194871287943953 928 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2077 5212015 200 µM 0.858706802317004 0.158690773276081 no 588 0.195251148305676 914 780900
SGTC_1667 st014849 34.6 µM 0.855468259601384 0.159497954464709 no 589 0.196145984395308 983 5348460
SGTC_1318 1280-3875 124 µM 0.855194246388051 0.159566373196813 no 590 0.196221810454232 946 373245
SGTC_1193 1488-0126 41.5 µM 0.853839714801348 0.15990487016832 no 591 0.196596903002981 1012 1384710
SGTC_1421 4029-0249 71.4 µM 0.851625924178584 0.160459106008163 no 592 0.197210873157994 1051 2894095
SGTC_652 0437-0092 114 µM 0.851617044307794 0.160461331661689 no 593 0.19721333822477 961 3091274
SGTC_3093 9117344 49.47 µM 0.850972122502202 0.160623028986809 no 594 0.197392419419702 915 24824913
SGTC_2927 9011802 47.9 µM 0.85066317503882 0.160700527196598 no 595 0.197478242448465 929 43912568
SGTC_1144 3486-0183 12.5 µM 0.845210464006192 0.162072335328653 no 596 0.198996670489059 994 6744069
SGTC_2301 7769476 200 µM 0.845132074081344 0.162092112330668 no 597 0.199018551072424 942 977820
SGTC_837 0091-0265 12.5 µM 0.844444863002415 0.162265556162045 no 598 0.199210430880279 980 759367
SGTC_2202 7226349 200 µM 0.841384441039222 0.163039436539442 no 599 0.200066299498033 962 844334
SGTC_2241 6772625 37.8075 µM 0.841114265787293 0.163107870061423 no 600 0.200141961952411 988 2285411
SGTC_380 3970-0968 6 µM 0.839373431442764 0.163549258962036 no 601 0.200629894099208 949 2891601
SGTC_212 3807-4682 38.772 µM 0.838048903573371 0.163885612367553 no 602 0.20100161919222 1118 3125501 YBL034C STU1
SGTC_2850 9015429 58.44 µM 0.834777954885137 0.164718165613892 no 603 0.201921370173714 975 6457570
SGTC_3050 9093513 49.47 µM 0.834334621266842 0.164831217632335 no 604 0.202046223784917 1033 25236664
SGTC_757 1066-0008 322 µM 0.831610715365517 0.165526928285461 no 605 0.202814355914009 1015 6842497
SGTC_941 3237-0776 460 µM 0.831214617691941 0.165628253225833 no 606 0.202926199214069 971 760008
SGTC_1250 0485-0349 40.2 µM 0.830900531473378 0.165708627489195 no 607 0.203014911700333 970 6842794 YDL195W SEC31
SGTC_2059 5238311 157 µM 0.8286843776418 0.166276455005522 no 608 0.203641514037407 972 703021
SGTC_2113 5491891 107.031 µM 0.82571454552747 0.167039359466609 no 609 0.204483019562332 1019 789979
SGTC_686 1319-0111 510 µM 0.825427769347863 0.167113147199627 no 610 0.204564387364762 1032 4562600
SGTC_2539 epi(13)torulosol 80 µM 0.824550261131263 0.167339061258842 no 611 0.204813484852748 986 6708597
SGTC_1255 0566-0045 221 µM 0.82328179659283 0.167665974550799 no 612 0.205173881440266 999 2788469
SGTC_1019 4262-0212 3.4 µM 0.821697190832431 0.168074942364808 no 613 0.205624629191477 1107 4677213
SGTC_1863 st057641 20.1 µM 0.821671641180183 0.168081541678986 no 614 0.205631901709088 1063 3921635
SGTC_2665 lovastatin 100 µM 0.819543697717542 0.168631761279049 no 615 0.206238140657945 1026 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.814303363882062 0.169991677611383 no 616 0.207735591560156 1049 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_144 4161-2749 112.381 µM 0.814297460766005 0.169993213479221 no 617 0.207737282017724 923 797501 YMR168C CEP3
SGTC_2427 5545055 42.75 µM 0.813492769385861 0.170202660662899 no 618 0.207967795108487 1057 5372858
SGTC_871 0574-0004 149 µM 0.812980005269421 0.170336210466048 no 619 0.208114761022094 989 9551173
SGTC_3150 9097574 49.47 µM 0.809739502371231 0.171181753855162 no 620 0.20904495468529 1014 17217476
SGTC_41 0478-0632 82.643 µM 0.809113187526958 0.171345486972813 no 621 0.209225021711246 1081 3750424
SGTC_1136 pergolide 1.05886 µM 0.809047936723441 0.17136255079127 no 622 0.209243786724695 991 47811 A dopamine receptor agonist.
SGTC_1029 k015-0030 64.7 µM 0.80666221138846 0.171987190611946 no 623 0.209930560507169 1003 2208316
SGTC_623 k072-0108 16.9 µM 0.805005457725847 0.172421822379029 no 624 0.210408265171228 1010 5382803
SGTC_893 0958-0369 48.9 µM 0.801253408665527 0.173408720035156 no 625 0.211492478761035 1059 6819948
SGTC_1692 fluoroquinolonic acid 71 µM 0.799170896463818 0.173958029738951 no 626 0.212095662519334 1018 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.798367401251822 0.174170265246929 no 627 0.21232865742907 1095 16486 A toxic proline analog.
SGTC_1559 coumarin 343 70.1 µM 0.798294175791454 0.17418961522477 no 628 0.21234989854263 1007 108770 A hepatotoxic, DNA x-linker.
SGTC_394 menadione 8.33 µM 0.795965198410046 0.174805764937344 no 629 0.213026131801137 1028 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2013 4024628 200 µM 0.794849161842198 0.175101511076728 no 630 0.213350624834126 1024 5230760
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.793297650872224 0.175513183548522 no 631 0.213802212579921 1031 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1279 0874-0590 65.2 µM 0.793054953513741 0.175577635453252 no 632 0.21387290316321 1049 3523074
SGTC_281 1672-3440 14.9 µM 0.791866437096466 0.17589348025861 no 633 0.21421927939806 1091 6833000
SGTC_869 0564-0080 44.1 µM 0.788929705147709 0.176675450151448 no 634 0.215076546410521 1009 6843321
SGTC_170 4197-0004 226 µM 0.78877464087653 0.176716800450618 no 635 0.215121866811087 994 218692
SGTC_1971 st069429 63.5 µM 0.788283524452304 0.176847804655586 no 636 0.21526544124761 1069 1246522 YGL099W LSG1
SGTC_176 1486-1328 72.834 µM 0.787317886345248 0.177105565401935 no 637 0.215547900869776 1071 22310231
SGTC_2966 9084041 48.03 µM 0.787037403618601 0.177180479975746 no 638 0.21562998537644 1029 17741380
SGTC_252 miconazole 1.30953 nM 0.785808815005268 0.177508861445596 no 639 0.215989750761221 1026 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1135 dihydrocapsaicin 536.708 nM 0.785788301382758 0.17751434765711 no 640 0.215995760678339 996 107982 A Capsaicinoid.
SGTC_1902 st060212 70.5 µM 0.783863815457292 0.178029512644584 no 641 0.216560011908516 1113 688944
SGTC_348 k064-0012 10.7 µM 0.783319714668768 0.178175333560967 no 642 0.216719694483385 1021 5066323
SGTC_980 1473-0395 201 µM 0.781074084194504 0.178777966634231 no 643 0.217379461644182 1014 768876
SGTC_1127 asiatic acid 681.4 nM 0.779662529217418 0.179157424786404 no 644 0.217794770005493 1011 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1351 1496-0003 46.5 µM 0.776393952732039 0.180038035700943 no 645 0.218758207066827 1095 3891978
SGTC_2178 5812956 200 µM 0.776239003648476 0.180079849018783 no 646 0.2188039402617 1102 5403383
SGTC_1009 4106-0057 9.87 µM 0.775904317088364 0.180170185655978 no 647 0.218902741714224 1112 2928005
SGTC_1474 0330-0125 5.35 µM 0.775758585945551 0.180209529440906 no 648 0.218945770429174 1111 X1474
SGTC_1067 clotrimazole 1.36 µM 0.775645798377339 0.180239982981236 no 649 0.218979075532665 1091 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1495 4469-0029 237 µM 0.774981873130338 0.180419313536313 no 650 0.219175185439423 1126 793680
SGTC_1437 4092-1038 11.6 µM 0.774563881919236 0.180532273099104 no 651 0.219298703250417 1105 3977136
SGTC_277 nystatin 15.5 µM 0.773918810230937 0.180706686800434 no 652 0.219489402596608 1106 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3202 9113761 49.47 µM 0.771843628896747 0.181268488104809 no 653 0.220103523932195 1099 4798415
SGTC_233 rapamycin 362 pM 0.771638198400363 0.181324162499214 no 654 0.220164371826053 1121 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1870 st057514 26.5 µM 0.769267800919336 0.181967346089923 no 655 0.220867173960162 1091 5393161
SGTC_3096 9117468 49.47 µM 0.768179493888322 0.182263124571418 no 656 0.221190277235109 996 41316311
SGTC_1961 st076550 68.7 µM 0.767275606344488 0.182509010055756 no 657 0.221458834350463 1034 1579337
SGTC_2993 9054257 71.4286 µM 0.766434964373156 0.182737876641359 no 658 0.22170876757788 1143 6470217 YGL055W OLE1
SGTC_2226 7298446 200 µM 0.766294877761324 0.182776032932486 no 659 0.221750432715782 1067 3283010
SGTC_1461 k072-0203 53.8 µM 0.765442092249482 0.183008418886029 no 660 0.222004168181421 1073 5418714
SGTC_407 eburnamonine 100 µM 0.764787683280172 0.183186871745691 no 661 0.222198991590736 1030 3195
SGTC_2513 baicalein 25.65 µM 0.764509170316756 0.183262853243676 no 662 0.222281936982665 1096 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1385 3091-4834 14.1 µM 0.763991908547415 0.183404020262643 no 663 0.222436032259013 1045 4072814
SGTC_2680 butyl paraben 22.24 µM 0.762090495340108 0.183923521408329 no 664 0.223002997584735 1116 7184 An antifungal and steroid mimetic.
SGTC_943 3253-1379 105 µM 0.761471087503436 0.184092952739261 no 665 0.223187870823155 1060 668464
SGTC_982 1491-0518 27.5 µM 0.761396587942462 0.184113337714055 no 666 0.22321011241304 1036 3091256
SGTC_2471 5466956 24.79 µM 0.760769585051307 0.184284957325582 no 667 0.223397351975444 1066 724419
SGTC_365 0121-0052 13.6 µM 0.759946460826924 0.184510409201819 no 668 0.223643294144603 1102 3101739
SGTC_1504 k297-0033 30 µM 0.759856223285133 0.184535135491617 no 669 0.223670265677925 1005 4388117
SGTC_42 0133-0086 60.653 µM 0.759753482291282 0.184563290402815 no 670 0.223700976679807 1079 162923 Model of phenazepam hydroxylation.
SGTC_2062 5245942 200 µM 0.759345613825031 0.184675088112557 no 671 0.223822919035856 1198 1376160
SGTC_3214 9129694 49.47 µM 0.758091117786362 0.185019212274007 no 672 0.224198218345916 1061 17158655
SGTC_1985 st071382 65.5 µM 0.757010600392773 0.185315931019129 no 673 0.224521755859084 1166 6123237
SGTC_35 0133-0054 64.071 µM 0.756974107540034 0.185325957404344 no 674 0.224532687475517 1069 99677
SGTC_1805 st050013 60.3 µM 0.756456539844601 0.185468195019911 no 675 0.22468775997567 1061 4037144
SGTC_2464 5717415 7.67 µM 0.754579858419692 0.185984511443104 no 676 0.225250556317746 1073 5285744
SGTC_1723 st034307 2.5525 µM 0.753039957450094 0.186408837088494 no 677 0.225712951604069 1130 867466
SGTC_2877 9040724 71.43 µM 0.752951271590884 0.186433293068143 no 678 0.225739598181689 1106 6463895
SGTC_1373 2887-0003 58.5 µM 0.750542799370522 0.187098212158187 no 679 0.22646392844344 1087 776948
SGTC_2687 chenodiol 100 µM 0.74765940579283 0.187896171687123 no 680 0.227332811278507 1087 5702181 A cholesterol synthesis inhibitor.
SGTC_1303 1160-0052 261 µM 0.745490392389858 0.188497814141865 no 681 0.227987658546751 1153 3562476
SGTC_994 3910-0338 138 µM 0.743106816707481 0.189160340408256 no 682 0.22870850646375 1157 3479481
SGTC_187 1488-2104 32.728 µM 0.740924612312086 0.189768150235346 no 683 0.229369575682604 1171 2852859
SGTC_3192 9110362 49.47 µM 0.740817651558118 0.189797972880954 no 684 0.229402005504597 1156 16649480
SGTC_1307 1187-1599 12.2 µM 0.739913114784688 0.190050289767959 no 685 0.229676358055428 1134 1538471
SGTC_2198 6589944 200 µM 0.739846450235775 0.190068893728373 no 686 0.22969658516437 1053 5290268
SGTC_3148 9097893 49.47 µM 0.737728111578523 0.190660637542961 no 687 0.23033984289352 1096 17174100
SGTC_2674 ligustilide 100 µM 0.737040687738555 0.190852907574109 no 688 0.230548803265567 1080 5319022 A signalling regulator.
SGTC_914 3820-6779 408 µM 0.735879884142226 0.191177850185976 no 689 0.230901900109395 1148 2893481
SGTC_2180 6301957 200 µM 0.734682550150904 0.191513373851323 no 690 0.231266425021657 1124 845462
SGTC_1910 st062352 60.4 µM 0.734020015311492 0.191699188035785 no 691 0.231468269743776 1133 2245730
SGTC_210 3551-0445 56.827 µM 0.733675817896625 0.191795765031036 no 692 0.231573170052178 1158 2865180 YOR207C RET1
SGTC_222 nsc-310342 10.666 µM 0.732740117585329 0.192058460023675 no 693 0.231858475323057 1099 432556
SGTC_2079 5212404 121 µM 0.729519482490884 0.192964325281818 no 694 0.232841977377535 1148 758462
SGTC_1280 0880-0253 10.1 µM 0.728909451203879 0.193136201721718 no 695 0.233028526544883 1119 6836607
SGTC_2067 5224629 34.075 µM 0.727607122110552 0.193503445819889 no 696 0.233427059789145 1142 2835000
SGTC_2015 5119600 184 µM 0.725356231616783 0.194139178457844 no 697 0.234116758427106 1139 2828786
SGTC_1676 st018489 23.4 µM 0.725131007622155 0.1942028597794 no 698 0.234185831691947 1117 3696235
SGTC_1062 mesoridazine 14.2 µM 0.724416463180422 0.194404978993038 no 699 0.234405047828523 1160 4078 A neuroleptic.
SGTC_401 neomycin 50 µM 0.722554289232442 0.194932323220809 no 700 0.234976880105656 1112 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1149 3909-7961 23.3 µM 0.722234731174557 0.195022905403621 no 701 0.23507508671546 1131 735261
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.722134748183129 0.195051251917355 no 702 0.235105818152955 1220 23665772 A membrane-active detergent.
SGTC_1337 1486-1011 40.3 µM 0.719679633597904 0.195748095330905 no 703 0.235861134353768 1179 X1337
SGTC_1063 disulfiram 1.84 µM 0.717572167446883 0.196347468162261 no 704 0.23651056198875 1171 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1238 0333-0287 48.8 µM 0.717042757707488 0.19649820931899 no 705 0.236673857114299 1165 7226
SGTC_864 0469-0573 172 µM 0.716822050427168 0.196561072977021 no 706 0.23674195204218 1147 689425
SGTC_2616 abietic acid 100 µM 0.716266116248365 0.196719472703168 no 707 0.236913522437829 1181 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2580 diallyl disulphide 81.36 µM 0.715840023740294 0.196840929568748 no 708 0.237045067824963 1139 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1562 morin hydrate 59.1 µM 0.712167946847518 0.197889528845929 no 709 0.238180391468426 1169 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2884 9058502 51.95 µM 0.711053963162879 0.198208304247217 no 710 0.238525398273009 1174 6471554
SGTC_2945 9067681 61.76 µM 0.708727824096509 0.198874946347059 no 711 0.239246697403184 1241 16456930
SGTC_2353 9059630 146.67 µM 0.705459359124984 0.199813927465259 no 712 0.240262207472491 1193 4779114
SGTC_1113 artemisinin 1.17947 µM 0.705130500495603 0.199908551056945 no 713 0.240364513537328 1189 2240 An anti-malaria and mitochondrial poison.
SGTC_992 3909-8734 162 µM 0.705072973108785 0.19992510637286 no 714 0.240382412421318 1195 4288319
SGTC_1028 k015-0029 4.8 µM 0.704999015681793 0.199946391161113 no 715 0.240405424361204 1194 4588309
SGTC_1467 k284-1082 293 µM 0.704836944523599 0.199993039656078 no 716 0.240455857187266 1167 3334705
SGTC_3079 9117512 49.47 µM 0.704701507856856 0.200032027037203 no 717 0.240498006389703 1213 7185044
SGTC_528 3492-0019 172 µM 0.704459063999405 0.200101829377949 no 718 0.24057346731253 1222 2869262
SGTC_993 3909-8757 62.7 µM 0.703767791919817 0.200300934836722 no 719 0.240788697283932 1128 4288324 YLR208W SEC13
SGTC_3159 9100096 49.47 µM 0.703227747638303 0.200456565300702 no 720 0.240956914827447 1163 25236875
SGTC_2889 9059656 51.95 µM 0.702470902474275 0.200674795819974 no 721 0.241192770853893 1242 3949838
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.702300437419433 0.200723967788204 no 722 0.241245910270948 1200 3256 An antibiotic and ribosome inhibitor.
SGTC_102 gallobenzophenone 83.616 µM 0.698398544552051 0.201851475415608 no 723 0.242463993165407 1217 70837
SGTC_127 0180-0333 59.125 µM 0.697785739699688 0.202028898030979 no 724 0.242655599260401 1180 771601
SGTC_2978 9011784 42.97 µM 0.697059536592676 0.202239273125296 no 725 0.242882767758576 1250 2994934
SGTC_1221 2958-7315 257 µM 0.695622534252256 0.202655946961391 no 726 0.243332625102242 1198 4562705
SGTC_2273 7815444 169.05 µM 0.693567491240361 0.203252718837554 no 727 0.24397674334559 1169 2824616
SGTC_2837 9008476 45.46 µM 0.692123795031733 0.203672585883683 no 728 0.244429794840589 1227 2992805
SGTC_2790 5423970 71.43 µM 0.690246496176746 0.204219329426825 no 729 0.245019594064634 1216 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_480 am 92016 50 µM 0.690231274934317 0.204223766022628 no 730 0.245024379316154 1140 2129 K+ channel blocker.
SGTC_3044 9093193 49.47 µM 0.690151515017306 0.204247014899836 no 731 0.245049455046778 1171 25236277
SGTC_3206 9114350 49.47 µM 0.687454644918844 0.205034041227429 no 732 0.245898136253245 1149 17087243
SGTC_1291 0993-0025 5.79 µM 0.687325601978234 0.205071744903307 no 733 0.245938784434664 1219 4353356
SGTC_2649 anisomycin 9.56 µM 0.687129934469626 0.205128922759496 no 734 0.246000426055008 1184 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_872 0588-0139 234 µM 0.68528947695958 0.205667203786927 no 735 0.246580635400238 1228 2047100
SGTC_2476 5806916 10.51 µM 0.683079838933679 0.206314565793781 no 736 0.24727819714129 1145 2870194
SGTC_1932 st074806 40.9 µM 0.682302221188079 0.206542672960771 no 737 0.247523934423301 1317 17251235
SGTC_1462 k081-0014 26.5 µM 0.680045497081338 0.20720550797904 no 738 0.248237826623116 1025 3270634
SGTC_1861 st057647 17.4 µM 0.678748495096162 0.207587026301869 no 739 0.248648616569633 1254 688668
SGTC_2669 eugenol 100 µM 0.677957232143762 0.207819983194237 no 740 0.248899405204394 1202 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_123 0083-0120 66.675 µM 0.677199813536886 0.208043120490301 no 741 0.249139593026288 1175 16001701
SGTC_1091 telmisartan 47.6 µM 0.674901950436719 0.208720941130022 no 742 0.249869030631192 1290 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3268 9137683 49.47 µM 0.674471304786309 0.208848117082845 no 743 0.250005861555562 1233 1953228
SGTC_1678 st019265 80.2 µM 0.673638308728842 0.209094242516434 no 744 0.250270645825564 1258 5367020
SGTC_244 nsc-207895 1.295 µM 0.671843705344538 0.20962507416703 no 745 0.250841600874271 1133 42640
SGTC_3243 9134147 49.47 µM 0.671605554653219 0.209695577063691 no 746 0.250917420570707 1285 24282180
SGTC_1339 1486-1321 22.7 µM 0.671365406970869 0.209766685273194 no 747 0.250993888327123 1245 3469382
SGTC_2027 5150920 200 µM 0.670869092438982 0.209913689917214 no 748 0.251151963728381 1225 786715
SGTC_2022 5136654 200 µM 0.668785859071392 0.210531388122555 no 749 0.25181604425212 1231 1713771
SGTC_1709 st033179 39.1045 µM 0.668591748147287 0.210588998107834 no 750 0.251877968936422 1219 573381
SGTC_644 1498-1197 63.3 µM 0.667840611196206 0.210812014424904 no 751 0.252117670104817 1273 6741615
SGTC_1050 3232-1156 69.3 µM 0.667635248656902 0.210873011693308 no 752 0.252183225885644 1218 700529
SGTC_1239 0337-0584 35.4 µM 0.665939547530019 0.211377068271426 no 753 0.25272487059115 1297 914301 YML130C ERO1
SGTC_1952 st077036 64.1 µM 0.664175933145189 0.211902060355878 no 754 0.253288857536954 1252 2937007
SGTC_726 3448-4391 34.2 µM 0.663075429904448 0.212230043889633 no 755 0.253641122899243 1322 1356692
SGTC_2078 5212016 200 µM 0.662034076249145 0.212540672116391 no 756 0.253974691578338 1181 1899708
SGTC_3301 9125354 19.7965 µM 0.661690637190455 0.212643175696097 no 757 0.25408475318367 1236 41905162
SGTC_2636 apigenin dimethyl ether 100 µM 0.660926893310618 0.212871227833965 no 758 0.254329599151175 1256 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_232 clozapine 119 µM 0.660807044923852 0.212907027235419 no 759 0.254368032148325 1229 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1803 st050068 52.4 µM 0.66058396254771 0.212973672578394 no 760 0.254439578341128 1333 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2096 5468907 200 µM 0.660139661521784 0.213106442739495 no 761 0.254582104409622 1259 759785
SGTC_1899 st063254 59.6 µM 0.659220368356205 0.213381307713344 no 762 0.25487713459143 1198 3093813
SGTC_3332 9141069 11.198 µM 0.658648120008689 0.213552511990673 no 763 0.255060877466301 1216 17332883
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.657803047598121 0.213805485628773 no 764 0.255332347919922 1325 6710655
SGTC_3350 9150499 3.57 µM 0.657516788600002 0.213891217224499 no 765 0.255424339786812 1231 4910996 YPR165W RHO1
SGTC_2734 clemastine 41.6 µM 0.656667024739753 0.214145830537996 no 766 0.255697520918772 1247 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2495 cafestol 54.53 µM 0.656029555490632 0.214336950097679 no 767 0.255902553921969 1273 16667697 An anti-infammatory.
SGTC_2335 9018011 154.17 µM 0.654673831256155 0.2147437392635 no 768 0.256338888610457 1287 6458208
SGTC_870 0573-2213 57.6 µM 0.653698403483824 0.215036696615122 no 769 0.256653066018984 1256 3916321
SGTC_2149 5554786 194.827 µM 0.653047448222047 0.215232331809174 no 770 0.256862844953632 1285 745063 YPR165W RHO1
SGTC_629 3448-6466 76.7 µM 0.652958845169862 0.215258968160416 no 771 0.256891405355771 1258 573744
SGTC_710 3448-4187 58 µM 0.651468941996769 0.215707157760914 no 772 0.257371909736064 1287 3946412
SGTC_2284 7945075 39.21 µM 0.648732916871522 0.216531610572617 no 773 0.258255512093372 1323 1245402
SGTC_1750 st081859 2.357 µM 0.648118971265389 0.216716862371882 no 774 0.258454002285721 1271 5291695
SGTC_1557 sumaresinolic acid 42.3 µM 0.645660145301165 0.217459705939176 no 775 0.25924973833517 1223 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1940 st075990 51.1 µM 0.645449532694181 0.217523403043161 no 776 0.259317956535808 1363 1084979
SGTC_3280 9140961 49.47 µM 0.642793727226162 0.218327541232735 no 777 0.260178976957913 1265 4901226
SGTC_849 0386-0493 241 µM 0.640635617326362 0.218982243993188 no 778 0.260879726518899 1261 726119
SGTC_582 0987-0078 156 µM 0.6392751087959 0.219395559216811 no 779 0.261321989115755 1313 1625765
SGTC_2134 5324836 1.464 µM 0.638320416883213 0.21968585695246 no 780 0.261632562071939 1269 699272
SGTC_3068 9116768 49.47 µM 0.635395541278702 0.220576609529995 no 781 0.262585237667728 1263 41904888
SGTC_1294 1000-1494 117 µM 0.633051789360362 0.221291875530649 no 782 0.263349911828426 1265 712797 YDL207W GLE1
SGTC_2948 9070189 9.45 µM 0.629321889031988 0.222432897078718 no 783 0.264569171949645 1230 6473636 YDL196W YDL196W
SGTC_2838 9002687 71.43 µM 0.628838853659575 0.222580908449041 no 784 0.264727280257336 1286 6457060
SGTC_1466 k213-0079 57.5 µM 0.628476540160981 0.222691965150314 no 785 0.264845905116395 1278 3657981
SGTC_824 1304-0008 100 µM 0.628278699050819 0.222752620937332 no 786 0.264910691566878 1302 768245
SGTC_1220 1838-0075 193 µM 0.625610269265238 0.223571649887213 no 787 0.265785300695779 1233 5529645
SGTC_1665 st014639 11.4 µM 0.625495406951636 0.223606943319309 no 788 0.265822980996397 1355 981133 YIL048W NEO1
SGTC_3223 9129970 49.47 µM 0.625145296848081 0.223714540248201 no 789 0.265937850459367 1366 17248386
SGTC_3335 9143315 29.6265 µM 0.622304915203355 0.22458854254792 no 790 0.266870694904565 1291 4899691
SGTC_2116 5511452 16.8835 µM 0.621651907913511 0.224789750283801 no 791 0.267085390497169 1325 870744
SGTC_2423 st077119 87.2 µM 0.620216298295289 0.225232456367422 no 792 0.267557696314039 1271 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_169 k015-0017 16.025 µM 0.619416103500164 0.225479430603246 no 793 0.267821137616169 1372 1840002
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.61892776890906 0.225630226771774 no 794 0.267981972026074 1303 7104
SGTC_2020 4017018 200 µM 0.61792026749659 0.225941520246905 no 795 0.268313949130281 1322 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1300 1094-0077 113 µM 0.615316597544836 0.226747114647027 no 796 0.269172829284726 1282 5532636
SGTC_3089 9117425 49.47 µM 0.614903837516651 0.226874974267875 no 797 0.269309114185207 1244 9401657
SGTC_783 0848-0141 92.7 µM 0.614153753245087 0.227107430031116 no 798 0.269556865181442 1315 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2018 5133068 143 µM 0.61320726573944 0.227400943889773 no 799 0.269869650580582 1327 785362
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.611929374910463 0.227797567562164 no 800 0.270292242785173 1417 5282309
SGTC_2345 9052315 157.45 µM 0.611757262460045 0.227851016468101 no 801 0.270349184795507 1329 6469265
SGTC_1237 0330-0133 46.1 µM 0.611329779691193 0.227983800238241 no 802 0.270490639945226 1292 X1237 YHR072W ERG7
SGTC_2809 7964133 12.99 µM 0.611044917002258 0.228072307830354 no 803 0.270584922271159 1343 1253665
SGTC_2334 9017922 200 µM 0.609948955689376 0.228413006039152 no 804 0.270947810671231 1376 3163164
SGTC_1623 st003709 20.3 µM 0.60960610823051 0.22851964469497 no 805 0.271061382190749 1311 16192618
SGTC_709 3807-1509 243 µM 0.609363967980352 0.228594976410189 no 806 0.271141607782556 1364 1886677 YPL242C IQG1
SGTC_2555 cholic acid 100 µM 0.608076690018168 0.228995692679267 no 807 0.27156830572364 1320 6708657 Influences liver metabolism.
SGTC_351 caspofungin 25 nM 0.60802598774433 0.229011483834042 no 808 0.271585119002959 1373 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1061 3448-9325 110 µM 0.604875402975004 0.22999392688411 no 809 0.272630893816484 1291 723482
SGTC_2224 6650123 117.647 µM 0.602094521869198 0.230863041929135 no 810 0.273555610417227 1303 2908370
SGTC_1273 0849-0096 14.1 µM 0.602072821873565 0.230869831081325 no 811 0.273562832339441 1335 5286025
SGTC_2293 7624732 200 µM 0.600939436003656 0.231224581905269 no 812 0.273940162815478 1288 894453
SGTC_3109 9122853 49.47 µM 0.599736956581021 0.231601291331874 no 813 0.274340777205186 1405 1234709
SGTC_1827 berberine 7.24 µM 0.598118744234094 0.232108779892066 no 814 0.274880352015561 1249 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_513 4245-1575 41.7 µM 0.596371550612268 0.232657412616799 no 815 0.275463520789681 1322 719745
SGTC_213 1246-0773 967 nM 0.595229280096443 0.23301648398536 no 816 0.275845110359115 1338 6251622
SGTC_1108 betulinic acid 729.144 nM 0.593969978697756 0.233412700282924 no 817 0.276266096311192 1343 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_48 0382-0018 55 µM 0.593661997544955 0.2335096578061 no 818 0.276369102733548 1447 762596
SGTC_2153 5569715 200 µM 0.593302045766583 0.233623004840091 no 819 0.276489514960659 1363 2054701
SGTC_509 pifithrin 175 µM 0.592816435801279 0.233775969343793 no 820 0.276652003519157 1429 4817 A p53 inhibitor.
SGTC_2004 4023728 41.89 µM 0.591681715176331 0.234133616489565 no 821 0.277031871473003 1331 360084 YDR527W RBA50
SGTC_3040 9091894 49.47 µM 0.591014892386804 0.234343930420436 no 822 0.277255221322578 1294 25236966
SGTC_2760 etidronate 98.04 µM 0.590894494006204 0.23438191485276 no 823 0.277295557703911 1328 3305 A chelator and antioxidant.
SGTC_1284 0929-0043 16 µM 0.590838138467481 0.234399695607527 no 824 0.277314439163981 1349 1239883
SGTC_2642 cholecalciferol 100 µM 0.589320362043729 0.234878850405003 no 825 0.277823194032926 1369 9821465 A vitamin D precursor, similar to steriods.
SGTC_1228 0124-0032 52.5 µM 0.589189116033225 0.234920309559855 no 826 0.277867208764986 1439 X1228
SGTC_378 3970-0959 8.33 µM 0.58834586190675 0.235186780597053 no 827 0.27815008408546 1369 6615653
SGTC_1115 galangin 695.678 nM 0.586810754565315 0.235672307723492 no 828 0.278665406552961 1394 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2608 thymoquinone 42.66 µM 0.585898179543606 0.235961200752056 no 829 0.278971970374677 1282 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1880 MG-132 525 µM 0.585601688225273 0.236055102721729 no 830 0.27907160680952 1333 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_580 1123-0028 41 µM 0.584596395599259 0.236373642846592 no 831 0.279409565930038 1401 1677248 YPR107C YTH1
SGTC_1352 1496-0991 99 µM 0.584576993770467 0.236379792896685 no 832 0.279416090388753 1351 3000039
SGTC_34 0469-0683 81.75 µM 0.584169556010166 0.236508964090948 no 833 0.279553120896537 1391 3690923
SGTC_1526 st051518 75 µM 0.583521366607775 0.236714541521036 no 834 0.279771188829904 1363 673993
SGTC_1379 2144-0755 36.5 µM 0.58331948452609 0.236778589786279 no 835 0.279839124113631 1388 5392327
SGTC_8 0354-0001 70 µM 0.582892408285769 0.236914113608743 no 836 0.279982865784392 1403 4993152
SGTC_1712 st032288 53.4 µM 0.582258140668223 0.23711546400337 no 837 0.280196408194594 1338 2883011
SGTC_920 mycophenolic acid 780.421 nM 0.58132958101093 0.237410407907508 no 838 0.280509173793518 1366 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1274 0865-0114 173 µM 0.580677472592897 0.237617661306099 no 839 0.280728923618343 1377 870624
SGTC_2849 9019321 12.99 µM 0.5796386289008 0.23794803204401 no 840 0.281079168753016 1367 16489627
SGTC_812 4251-0442 148 µM 0.578813499203776 0.238210617279608 no 841 0.281357510764254 1356 5723007
SGTC_2260 7964312 200 µM 0.57875797738392 0.238228291970676 no 842 0.281376244783748 1430 231951
SGTC_550 4123-0385 25.7 µM 0.573787561554209 0.239813470506222 no 843 0.283055783414938 1356 5731123
SGTC_613 3914-0030 117 µM 0.573704744359099 0.239839931440553 no 844 0.283083808635885 1251 1145395
SGTC_2592 piperlongumine 83.33 µM 0.571301995326438 0.240608327146221 no 845 0.283897474700625 1322 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1288 0973-0013 65.5 µM 0.570895537224749 0.240738444268376 no 846 0.284035228139804 1426 4315430
SGTC_1489 4065-0444 182 µM 0.569562976230303 0.241165297886016 no 847 0.284487072888135 1388 2877968
SGTC_1172 0370-0043 85 µM 0.569377742365368 0.241224665617562 no 848 0.284549909153595 1425 376585
SGTC_850 0388-0143 75.9 µM 0.569188819332443 0.241285223913954 no 849 0.28461400371006 1364 67273
SGTC_364 0083-0097 67.7 µM 0.566518730639904 0.242141989804271 no 850 0.285520601843517 1423 5207356
SGTC_208 k072-0098 12.366 µM 0.56631672349745 0.242206875981521 no 851 0.285589246960487 1375 5948901
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.565884722124434 0.242345669619108 no 852 0.285736073988512 1375 115019
SGTC_1225 1216-0074 20.6 µM 0.565382203914744 0.242507173152844 no 853 0.285906913182813 1361 4241466
SGTC_1446 4239-0190 62 µM 0.563223138973507 0.243201734440134 no 854 0.286641474219124 1374 1340085
SGTC_405 ebelactone b 50 µM 0.562309436043648 0.243495992022289 no 855 0.286952605202658 1384 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1187 1391-0724 117 µM 0.561593592150774 0.243726663493894 no 856 0.28719647362242 1407 6997986
SGTC_945 3381-0768 11.3 µM 0.561232694193885 0.243843002925623 no 857 0.287319458863246 1388 1126236 YIL048W NEO1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.560055758677811 0.244222609199133 no 858 0.287720702883677 1450 551469
SGTC_972 1319-0219 195 µM 0.559514226398392 0.244397380831138 no 859 0.287905412419623 1354 23903702
SGTC_673 1082-0474 110 µM 0.559209193279069 0.244495855479959 no 860 0.288009479850366 1394 3098046
SGTC_1966 st070145 16.1 µM 0.556056767503157 0.2455148122685 no 861 0.289086024114061 1326 3748532
SGTC_630 4356-0227 183 µM 0.555971924622431 0.245542267475996 no 862 0.289115023845639 1421 779312
SGTC_1264 0783-0040 158 µM 0.555592393885835 0.245665104040271 no 863 0.289244766141602 1353 2855798
SGTC_2750 bromebric acid 70.15 µM 0.554769730033569 0.245931475570692 no 864 0.289526087071464 1454 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2337 9009472 200 µM 0.554592019884616 0.245989036949184 no 865 0.289586874310079 1490 5742383
SGTC_575 k072-0246 11.9 µM 0.553436418009115 0.246363519567711 no 866 0.289982303662365 1421 6796779
SGTC_2470 5664817 21.68 µM 0.553269704502295 0.246417569707814 no 867 0.290039371373187 1436 2859561
SGTC_1133 3473-0247 50 µM 0.551014419261436 0.247149379180075 no 868 0.290811895026735 1357 711311
SGTC_1390 3413-2614 145 µM 0.549971686103203 0.247488124484503 no 869 0.29116939694087 1409 3421432
SGTC_3043 9092303 49.47 µM 0.549825573800325 0.247535610758284 no 870 0.291219508050789 1340 25236084
SGTC_966 1300-0360 30.2 µM 0.548418420448046 0.247993182514427 no 871 0.291702315524416 1409 70588
SGTC_1156 4092-0367 4.88 µM 0.547938167364864 0.24814945227807 no 872 0.291867180195265 1415 1357585
SGTC_692 k241-0027 77.8 µM 0.546605627423015 0.248583322934081 no 873 0.29232485105589 1495 3600480
SGTC_3143 9086658 49.47 µM 0.54550093898529 0.248943312029705 no 874 0.29270451744907 1452 25236626
SGTC_1865 st057639 52.2 µM 0.544676466377649 0.249212166805443 no 875 0.29298802663328 1416 688818
SGTC_496 calpeptin 138 µM 0.544301679127198 0.249334433348367 no 876 0.293116945829261 1366 73364 A calpain inhibitor.
SGTC_2694 st077685 81.9 µM 0.544210416422045 0.249364210734482 no 877 0.293148342327357 1355 2838096
SGTC_1938 st074717 56.4 µM 0.543124734894712 0.249718594132712 no 878 0.293521961648209 1349 17250979
SGTC_2818 7996756 12.99 µM 0.541883260417445 0.25012415832378 no 879 0.293949464592035 1394 2241621
SGTC_2445 5742597 35.57 µM 0.541604766789121 0.250215184422975 no 880 0.29404540366726 1380 1774255
SGTC_1942 st076330 65.2 µM 0.541425696034333 0.250273723271072 no 881 0.294107099914033 1444 24208414
SGTC_2996 9066192 71.4286 µM 0.54110050132819 0.250380049108435 no 882 0.294219156356108 1356 6472854
SGTC_643 k048-0106 28.4 µM 0.540808029413141 0.250475696331488 no 883 0.294319953936449 1472 6763920
SGTC_9 0092-0002 10.449 µM 0.540599063969226 0.250544046252733 no 884 0.294391981595662 1419 759368
SGTC_887 0885-0007 9.62 µM 0.538097563622636 0.251363021600948 no 885 0.295254847201224 1487 5719458
SGTC_339 3091-4833 71.4 µM 0.537912104438035 0.251423796059154 no 886 0.295318865674957 1430 3240077
SGTC_3210 9128157 49.47 µM 0.537563398296794 0.251538087115695 no 887 0.295439252498023 1413 17590849
SGTC_1372 2752-0194 270 µM 0.537238173516784 0.251644706714178 no 888 0.295551552989183 1381 823334
SGTC_2005 4024620 188 µM 0.536408155624662 0.251916922600359 no 889 0.295838248051046 1412 236743
SGTC_2761 levamisole 97.89 µM 0.536291872603867 0.251955071638895 no 890 0.295878423370034 1517 26879 An alkaline phosphatase inhibitor.
SGTC_1829 berberine 14.4 µM 0.534566751822225 0.252521390953597 no 891 0.296474739800343 1512 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1357 1503-1303 39.5 µM 0.533481453532399 0.252878013970078 no 892 0.296850173057049 1451 292895
SGTC_107 0358-0022 2.6945 µM 0.530753997719282 0.253775409768416 no 893 0.297794630968957 1500 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3001 9076041 71.4286 µM 0.530366149298492 0.253903156483505 no 894 0.297929045570109 1420 16004211
SGTC_2254 7938975 95.19 µM 0.528929238667137 0.254376729721596 no 895 0.298427269063395 1520 2969277
SGTC_929 2805-0021 398 µM 0.527683231998641 0.25478775980522 no 896 0.298859606649449 1481 3098024
SGTC_792 4534-1957 155 µM 0.527387306766967 0.254885430073545 no 897 0.298962328161572 1452 1717904
SGTC_2036 5160441 105 µM 0.52664985595934 0.255128911309895 no 898 0.299218381696223 1486 134534 YIL048W NEO1
SGTC_1185 1319-0113 81.3 µM 0.525592170143748 0.255478335512586 no 899 0.299585799040758 1478 4672763
SGTC_1408 3909-7976 48.8 µM 0.524912859312036 0.255702889006862 no 900 0.299821884806279 1468 24152374
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.52431552591315 0.255900429098569 no 901 0.300029549939325 1421 689007
SGTC_567 1080-0542 68.4 µM 0.524229406682316 0.255928915574482 no 902 0.300059494970244 1443 5950415
SGTC_641 4092-0595 30 µM 0.52404692574229 0.255989281995471 no 903 0.300122950972412 1477 786260
SGTC_2072 5231554 129 µM 0.523173246351111 0.256278406294604 no 904 0.30042684868154 1508 789545
SGTC_3003 9075612 71.4286 µM 0.523021077505844 0.256328780508987 no 905 0.300479792793938 1448 6501993
SGTC_1613 st002381 52.1 µM 0.5207315343461 0.25708733701226 no 906 0.301276901809328 1428 551167
SGTC_315 k915-0449 187 µM 0.519988487949787 0.257333768982013 no 907 0.30153579942228 1508 20970215 YNL149C PGA2
SGTC_2995 9067767 71.4286 µM 0.518662823951258 0.257773731267159 no 908 0.301997945297612 1467 11673567
SGTC_877 0771-0151 33.1 µM 0.517772457587505 0.258069445691144 no 909 0.302308518522874 1482 6166523
SGTC_370 0180-0345 38.7 µM 0.517199794549784 0.25825973528686 no 910 0.302508347720217 1440 3989527
SGTC_1864 st057645 30.4 µM 0.516383999394683 0.258530940536375 no 911 0.302793119418934 1471 688666
SGTC_1846 st056244 14.8 µM 0.516301205875953 0.258558472889899 no 912 0.302822027073013 1489 5393182
SGTC_1649 st011737 51.3 µM 0.515981443210963 0.25866482178145 no 913 0.302933684955853 1433 1761035
SGTC_2763 lisinopril 49.32 µM 0.515648659304791 0.258775525410704 no 914 0.303049909288863 1427 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1539 benzyladenosine 56 µM 0.515241372545436 0.258911046460987 no 915 0.303192180786209 1432 92208 A nucleotide analog.
SGTC_1012 4112-3522 18 µM 0.513967209953538 0.259335249719606 no 916 0.303637458017531 1506 3112398
SGTC_555 4296-0685 37 µM 0.513333627979221 0.25954631993125 no 917 0.303858982357069 1488 2908540 YHR072W ERG7
SGTC_970 1315-0089 19.5 µM 0.510889969269109 0.260361225476526 no 918 0.304714052669787 1398 6811083 YLR033W RSC58
SGTC_2906 7926292 26.41 µM 0.510878098286744 0.260365187398244 no 919 0.304718209102495 1452 2966319
SGTC_1900 st060200 72.8 µM 0.509975987429385 0.260666356308639 no 920 0.305034142357494 1473 688945
SGTC_636 0kpi-0074 126 µM 0.509138167973069 0.260946222089549 no 921 0.305327689975716 1466 616434
SGTC_146 3448-8650 53.125 µM 0.509100305881949 0.260958873216546 no 922 0.305340958712431 1503 2891488 YIL048W NEO1
SGTC_412 gemfibrozil 100 µM 0.508988501517099 0.26099623303664 no 923 0.30538014194699 1450 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1433 4060-0023 7.6 µM 0.508003050399421 0.261325643882714 no 924 0.305725601988882 1509 3840627
SGTC_283 0987-0079 11.7 µM 0.508002877461646 0.261325701710081 no 925 0.305725662629189 1507 411556
SGTC_2543 pimpinellin 60.67 µM 0.507136534358211 0.261615474162684 no 926 0.306029511050772 1416 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_331 k048-0133 24.5 µM 0.50645101047075 0.261844883436958 no 927 0.306270036243019 1448 6813582
SGTC_3088 9117578 49.47 µM 0.505746829176964 0.262080643758086 no 928 0.306517194595826 1502 678341
SGTC_2244 6635614 200 µM 0.505663318329581 0.262108610454727 no 929 0.306546511643772 1477 836499
SGTC_3304 9125678 46.087 µM 0.504992708998991 0.262333244237642 no 930 0.306781978460961 1464 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2767 sibutramine 71.45 µM 0.5037642805859 0.262744986068482 no 931 0.307213515569334 1577 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3269 9137823 49.47 µM 0.503521828604989 0.262826289612785 no 932 0.30729871859755 1440 17682936
SGTC_591 4299-0174 154 µM 0.502602477188985 0.263134700615028 no 933 0.307621893643539 1493 5509088
SGTC_2388 9080168 200 µM 0.502511979166853 0.263165069604406 no 934 0.307653714043055 1425 15943073
SGTC_341 1486-1430 230 µM 0.501039207729977 0.263659548324736 no 935 0.308171764819799 1427 2054753 YPL210C SRP72
SGTC_1768 st044301 37.178 µM 0.499387791198524 0.264214569759132 no 936 0.308753109196113 1452 3931349
SGTC_599 1935-0052 86.5 µM 0.498621887076161 0.264472182844443 no 937 0.309022891547778 1460 9557311
SGTC_595 3909-8003 73.7 µM 0.498225597222469 0.264605525735991 no 938 0.309162521293488 1512 699517
SGTC_3239 9133757 49.47 µM 0.497962021405331 0.26469423218263 no 939 0.309255405516231 1542 17036923
SGTC_3347 9188721 44.724 µM 0.497771845167878 0.264758245390481 no 940 0.309322431270111 1495 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_445 e6 berbamine 66 µM 0.497148004223635 0.264968285125555 no 941 0.309542342442969 1496 6610268 A calcium/calmodulin antagonist.
SGTC_2017 5132927 60.65 µM 0.49654939033115 0.265169910790092 no 942 0.309753424920316 1442 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1831 st055328 12 µM 0.496170508893682 0.265297566224688 no 943 0.309887058047555 1568 1103068
SGTC_768 0384-0033 77.3 µM 0.49463910870204 0.265813854170819 no 944 0.310427445390728 1449 3965305 YMR134W ERG29
SGTC_1908 st060353 56.5 µM 0.492870230353636 0.26641083737872 no 945 0.311052141592623 1654 4227716
SGTC_2749 bexarotene 57.39 µM 0.492826495910856 0.266425606014331 no 946 0.311067593735143 1461 82146 An retinoic acid receptor inhibitor.
SGTC_1405 3909-7894 12 µM 0.492429582674476 0.266559658140389 no 947 0.311207845338702 1567 7104060
SGTC_1277 0873-0036 22 µM 0.492170319450056 0.266647239232567 no 948 0.311299472312296 1596 5965735
SGTC_2008 4012253 172 µM 0.490935770048865 0.2670644788991 no 949 0.311735938341086 1477 603940
SGTC_1763 st044482 94.5 µM 0.490559734135316 0.267191632920758 no 950 0.311868935722289 1543 88505
SGTC_765 1319-0117 244 µM 0.490186598626062 0.267317836387254 no 951 0.312000931533718 1440 3487746 YGL099W LSG1
SGTC_63 0099-0242 26.702 µM 0.489404949360134 0.267582306555568 no 952 0.312277516378942 1486 3898502 YLR359W ADE13
SGTC_1010 4112-3296 15.2 µM 0.48903100868225 0.267708875602929 no 953 0.312409871883194 1622 704384
SGTC_473 2-arachidonoylglycerol 10 µM 0.487489806515993 0.268230850068871 no 954 0.312955632417084 1477 5282280 An endocannabinoid.
SGTC_622 1348-1566 26.3 µM 0.487091991600857 0.268365665151697 no 955 0.313096570703756 1581 7340407
SGTC_2918 7977171 22.06 µM 0.485380601952531 0.268946024582183 no 956 0.313703194901217 1476 2236483
SGTC_2705 st078069 42.8 µM 0.48490106857533 0.269108754910034 no 957 0.313873262184828 1475 1530061
SGTC_2826 7992541 19.48 µM 0.48377832846484 0.269489951508013 no 958 0.314271598419135 1543 2985066
SGTC_1600 coumarin 106 71.1 µM 0.483653706615647 0.269532280229506 no 959 0.314315826275238 1555 100336 A hepatotoxic, DNA x-linker.
SGTC_1702 st027038 51 µM 0.483488285428187 0.269588471890392 no 960 0.314374537790823 1526 5521182
SGTC_342 k048-0088 23.3 µM 0.483342634987903 0.269637952516335 no 961 0.314426236133209 1464 6820570
SGTC_306 1672-3436 11.6 µM 0.482899658343846 0.269788469283035 no 962 0.314583492201635 1539 6797378
SGTC_262 fenpropimorph 62.5 µM 0.482575167741016 0.26989875297542 no 963 0.31469870724624 1468 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1171 0368-0077 21.4 µM 0.48123591366024 0.270354160062906 no 964 0.315174419430366 1480 3239779
SGTC_3120 9124077 49.47 µM 0.480977800802647 0.270441974260655 no 965 0.315266138148536 1515 18774327 YGL155W CDC43
SGTC_2160 5660466 132.927 µM 0.480258177074915 0.270686877216177 no 966 0.31552191185632 1544 2859134
SGTC_1519 esterone 74 µM 0.479493864635248 0.270947109888685 no 967 0.315793665954986 1433 698 A steroid.
SGTC_2813 7971799 71.43 µM 0.478632027387817 0.271240697412411 no 968 0.31610021483926 1549 2234054
SGTC_2424 5537928 59.2 µM 0.474660470363363 0.27259566642332 no 969 0.317514498775687 1500 5382802
SGTC_1969 st069479 40.1 µM 0.474172576753279 0.272762351654353 no 970 0.317688423625825 1599 3895485
SGTC_1796 st049173 110.4 µM 0.473249709658431 0.273077780573345 no 971 0.318017518324487 1532 94134
SGTC_3172 9105863 49.47 µM 0.472541860877121 0.2733198403326 no 972 0.318270034857509 1548 2348785
SGTC_2193 5925765 200 µM 0.471873358917785 0.273548542370838 no 973 0.318508592451731 1565 877370
SGTC_1314 1222-0010 41.1 µM 0.471801018622745 0.273573296477102 no 974 0.318534411889375 1533 3526027
SGTC_2325 6158266 200 µM 0.470949726863377 0.273864683030206 no 975 0.318838318054097 1512 3623240
SGTC_67 0335-0847 266 µM 0.470923250073786 0.273873748165004 no 976 0.318847772067626 1753 4552207 YOR254C SEC63
SGTC_1121 fusaric acid 630.51 nM 0.470799086045978 0.273916261478173 no 977 0.318892108637558 1499 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2704 st078022 71.1 µM 0.46761190662137 0.275008655473793 no 978 0.320031074338361 1639 54697681
SGTC_2304 7443016 91.4 µM 0.466584801829702 0.275361148555721 no 979 0.320398481342832 1504 939854
SGTC_40 0327-0103 19.753 µM 0.466580669613876 0.275362567143759 no 980 0.320399959839083 1488 409036
SGTC_2840 9008771 71.43 µM 0.466056064218867 0.275542693169762 no 981 0.32058768545362 1658 2992978
SGTC_1243 0416-0003 5.65 µM 0.465119084356496 0.275864554249581 no 982 0.320923089976351 1521 2141977
SGTC_786 4544-0069 423 µM 0.464194709130713 0.276182266417429 no 983 0.321254125767786 1591 748821 YLR208W SEC13
SGTC_2359 9039622 200 µM 0.463980707150415 0.276255845510119 no 984 0.321330784079263 1585 6463596
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.461844194583575 0.276990957490876 no 985 0.322096527754272 1569 368090
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.460349264624901 0.277505888307057 no 986 0.322632772638766 1509 688803
SGTC_2137 5261020 140 µM 0.459080311347675 0.277943347914684 no 987 0.323088247360353 1522 763655
SGTC_2400 5203494 178.7 µM 0.457369468110045 0.278533677141754 no 988 0.323702752931454 1508 6777674
SGTC_2799 7812892 81.82 µM 0.457103829870626 0.278625390793294 no 989 0.323798208813136 1634 20205235
SGTC_2122 5258151 111.688 µM 0.456707851588247 0.278762132643964 no 990 0.323940523307152 1506 2173356
SGTC_1196 1588-0294 184 µM 0.455865827480067 0.27905301453976 no 991 0.324243232095654 1503 6144269
SGTC_2925 9010536 32.5 µM 0.455036505615326 0.279339652579933 no 992 0.324541488012085 1634 2994177
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.453511386877247 0.279867151612613 no 993 0.325090272893619 1640 1377
SGTC_1701 st028638 40.4 µM 0.453211299731379 0.279971000831634 no 994 0.32519829826597 1636 3490878
SGTC_499 genistein 192 µM 0.450455888818295 0.280925420457174 no 995 0.326190876940825 1627 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3066 9117245 49.47 µM 0.448071753053808 0.281752504724422 no 996 0.327050706568369 1648 17176980
SGTC_1469 k284-2957 126 µM 0.447449958824683 0.281968405154958 no 997 0.327275105582105 1591 23884841
SGTC_15 0266-0086 27.098 µM 0.446346243479216 0.28235183519535 no 998 0.32767357861488 1613 1712902 YIL048W NEO1
SGTC_1088 bifonazole 369 nM 0.446344033648197 0.282352603140846 no 999 0.327674376624622 1533 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1960 st011366 51.8 µM 0.445361435198221 0.282694168609946 no 1000 0.328029288544768 1547 3972846
SGTC_143 4032-1194 15.74 µM 0.445172140557975 0.282759992974591 no 1001 0.328097679115045 1564 1806963
SGTC_2235 salicylic acid 500 µM 0.444771009688588 0.282899504532444 no 1002 0.328242623387655 1591 338 A COX inhibitor and kinase inhibitor.
SGTC_147 4466-0538 29.23 µM 0.443901797419849 0.283201926115307 no 1003 0.328556792490498 1593 6742687 YHR072W ERG7
SGTC_2002 4023503 131 µM 0.442723666275733 0.283612076016752 no 1004 0.328982811094638 1697 4736863 YCR052W RSC6
SGTC_933 2914-0560 114 µM 0.442391645125936 0.283727715920897 no 1005 0.329102911907213 1719 463887
SGTC_2097 5376186 200 µM 0.43850159640981 0.285084263310542 no 1006 0.330511356580114 1646 742755
SGTC_1775 st081588 35.1725 µM 0.43795826630422 0.28527398053958 no 1007 0.330708268354953 1554 1426443 YGL099W LSG1
SGTC_2104 5389443 200 µM 0.436837354418818 0.285665564759281 no 1008 0.331114653286878 1654 2244536
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.435457527922118 0.286147950222603 no 1009 0.331615180590798 1564 4620898
SGTC_59 0330-0160 1.33 µM 0.433999171279425 0.286658209934884 no 1010 0.332144521422917 1607 4293482
SGTC_1901 st060216 58.6 µM 0.433652858067319 0.286779443717167 no 1011 0.332270272271875 1554 688792
SGTC_311 1315-0136 58 µM 0.433489474782928 0.286836647700432 no 1012 0.332329605433413 1651 6759207
SGTC_2920 7982904 15.77 µM 0.432585991257502 0.287153074204194 no 1013 0.332657784198605 1538 6456808
SGTC_3022 9087993 49.47 µM 0.431675202163855 0.287472226498859 no 1014 0.332988746465645 1633 17173644
SGTC_417 st075190 100 µM 0.431628319781587 0.28748865923135 no 1015 0.333005786095612 1672 222757
SGTC_2102 5377816 72.7585 µM 0.42721462436948 0.289037688197124 no 1016 0.334611505213766 1705 1379702
SGTC_1563 conessine 56.1 µM 0.426953407293821 0.289129487767622 no 1017 0.334706632215137 1637 441082 An anti-amoebic, histamine inhibitor.
SGTC_253 dyclonine 31.25 µM 0.423544635308633 0.290328688116302 no 1018 0.335948969869432 1647 3180 An oral anasthetic.
SGTC_969 1313-0238 134 µM 0.423312212667548 0.290410538768424 no 1019 0.336033742530095 1597 5212874
SGTC_1078 idebenone 36.1 µM 0.422179478900397 0.290809600218429 no 1020 0.336447009438188 1600 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_400 oxethazaine 37.5 µM 0.417796403108238 0.292356165391153 no 1021 0.338047990469328 1581 4621 A local anesthetic.
SGTC_1724 st037281 8.293 µM 0.417028725238777 0.29262743308507 no 1022 0.338328698481501 1562 574124 YDL195W SEC31
SGTC_2252 omeprazole 400 µM 0.416663027694278 0.292756697571437 no 1023 0.338462450547241 1672 4594 A proton pump inhibitor.
SGTC_2197 6588183 93.1375 µM 0.414007686883524 0.293696085120723 no 1024 0.33943423865567 1598 884136
SGTC_962 1254-0300 21.5 µM 0.413630325867785 0.293829698350325 no 1025 0.339572430197563 1629 7340576
SGTC_2820 7989630 71.43 µM 0.413249126143808 0.293964699305168 no 1026 0.339712049396063 1695 2984098
SGTC_2989 9073649 71.4286 µM 0.41128218925534 0.294661740572559 no 1027 0.340432813986293 1700 21367202
SGTC_3106 9121286 49.47 µM 0.410863240508192 0.294810305665688 no 1028 0.340586409046925 1670 15943471
SGTC_3016 9080866 49.47 µM 0.409731560686194 0.295211787700076 no 1029 0.341001437807304 1570 17066299
SGTC_2863 9028737 58.44 µM 0.407913695912325 0.295857231472188 no 1030 0.341668518669717 1722 6460917
SGTC_2676 harmalol 100 µM 0.407103776726009 0.296145006692098 no 1031 0.341965884826808 1677 5459187 A monoamine oxidase inhibitor
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.406842827422058 0.296237752850484 no 1032 0.342061714653595 1639 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2912 7964298 10.93 µM 0.406365906343774 0.296407293745693 no 1033 0.342236883251401 1600 2975850
SGTC_38 0929-0051 58.268 µM 0.405539408832664 0.296701211008534 no 1034 0.342540528346422 1772 1379719
SGTC_2322 7413319 38.22 µM 0.404268055261511 0.297153587367611 no 1035 0.343007806785985 1645 1840400
SGTC_2692 st077426 47.7 µM 0.400464611384571 0.298508817703942 no 1036 0.344407171794297 1718 25238571
SGTC_3092 9117248 49.47 µM 0.400264230567507 0.298580294633044 no 1037 0.34448095530482 1708 17141857
SGTC_3140 9094243 49.47 µM 0.400144900238356 0.29862286410929 no 1038 0.344524897505169 1630 19291112
SGTC_2651 TUB2.036 5 µM 0.399709695191657 0.29877814098913 no 1039 0.344685175188245 1701 15992207 YFL037W TUB2
SGTC_2855 9016525 58.44 µM 0.397838277542931 0.299446262159316 no 1040 0.345374699889542 1588 43811474
SGTC_2675 theaflavin digallate 100 µM 0.397422611547984 0.2995947523743 no 1041 0.345527921991648 1637 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2764 methyldopa 94.69 µM 0.396409772016837 0.299956713179687 no 1042 0.345901379144966 1735 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_68 0986-0284 82.829 µM 0.395664495261493 0.300223180776078 no 1043 0.346176275565676 1549 423278 YIL048W NEO1
SGTC_1 0258-0098 57.368 µM 0.394837584663655 0.300518961063521 no 1044 0.346481377623196 1617 6790032 YDR047W HEM12
SGTC_3248 9135562 49.47 µM 0.394022015047715 0.3008108135955 no 1045 0.346782392832963 1645 17650701
SGTC_1038 k292-0204 154 µM 0.393997200554048 0.300819695494892 no 1046 0.346791553029054 1576 4454212
SGTC_2165 5727197 32.143 µM 0.393455541466898 0.301013602040677 no 1047 0.346991527165796 1689 1361712
SGTC_1804 st050076 49.1 µM 0.392640876558618 0.301305346984739 no 1048 0.347292372071742 1666 3895976
SGTC_810 3825-7150 143 µM 0.388430028965389 0.302815346549229 no 1049 0.348848912721564 1809 22330411 YGL099W LSG1
SGTC_2032 5185112 25.99 µM 0.387641018037142 0.303098660468421 no 1050 0.349140854920119 1657 5718189
SGTC_548 1436-0017 110 µM 0.38745120903326 0.303166833782132 no 1051 0.349211099545223 1769 9677137
SGTC_259 usnic acid 108.925 µM 0.387135022454063 0.303280413095314 no 1052 0.349328125525564 1707 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1727 st034309 9.9045 µM 0.386909285260135 0.303361513167832 no 1053 0.349411683429773 1768 870305
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.385436428717479 0.303890900609531 no 1054 0.349957048635555 1633 688667
SGTC_358 0075-0058 9.45 µM 0.384144992470192 0.304355419046532 no 1055 0.350435492893183 1892 1069125
SGTC_2351 9026858 72.31 µM 0.38411087133546 0.304367696408853 no 1056 0.350448137127321 1570 1409300
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.383378286252614 0.304631346098193 no 1057 0.350719650389246 1671 4213774
SGTC_3115 9123671 49.47 µM 0.382079852539084 0.305098888141046 no 1058 0.351201067764496 1710 3286988
SGTC_2303 7774051 200 µM 0.380523222976523 0.305659821245874 no 1059 0.351778530651418 1733 2953184
SGTC_2275 7947463 200 µM 0.379400805491512 0.306064568840577 no 1060 0.352195126249573 1709 1225414
SGTC_236 1509-0011 5.31 µM 0.37824993612416 0.306479822268962 no 1061 0.35262246626957 1690 3107280
SGTC_1346 1488-2224 62.4 µM 0.377920478418129 0.3065987420615 no 1062 0.352744834555989 1772 3722427
SGTC_1321 1326-2144 215 µM 0.377658692505576 0.306693249823446 no 1063 0.35284207882215 1743 3513030
SGTC_139 0099-0334 718.624 µM 0.377646100477633 0.306697796016158 no 1064 0.352846756560391 1705 97690
SGTC_2748 diazoxide 86.69 µM 0.377561325303953 0.30672840379633 no 1065 0.352878249768949 1707 3019 A potassium channel activatior.
SGTC_540 1187-0821 17.3 µM 0.374804072754647 0.307724633943715 no 1066 0.353903092547572 1617 847520
SGTC_1375 2910-0797 186 µM 0.37461334429842 0.307793599109512 no 1067 0.35397402364015 1682 742508
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.374526497952055 0.307825003976858 no 1068 0.354006323102258 1617 4330530
SGTC_2952 9073731 13.78 µM 0.374356955032613 0.307886317151634 no 1069 0.354069381690688 1605 16457353
SGTC_484 loperamide 105 µM 0.371858014303986 0.3087906507221 no 1070 0.354999283368505 1679 3955 An opioid-receptor agonist.
SGTC_685 1278-0033 54.9 µM 0.371635054634494 0.308871393348829 no 1071 0.355082292832296 1746 3590572
SGTC_77 0828-0286 12.516 µM 0.369706923583991 0.309570031868415 no 1072 0.355800436244252 1588 745345
SGTC_3196 9111891 49.47 µM 0.368687917587625 0.309939536582045 no 1073 0.356180177828338 1651 18891510
SGTC_1688 st021091 57.6 µM 0.367857614536746 0.310240757207071 no 1074 0.356489703112556 1789 3656366
SGTC_1402 3909-7673 35.9 µM 0.366953843949634 0.31056877543396 no 1075 0.356826723526926 1643 5328014
SGTC_3028 9087778 49.47 µM 0.365360950380065 0.311147273498343 no 1076 0.357420993224036 1607 17217395
SGTC_758 0868-0029 16 µM 0.365098605890764 0.311242595097039 no 1077 0.35751890076303 1802 762687
SGTC_888 0916-0002 6.97 µM 0.364814191618232 0.31134594994629 no 1078 0.357625055388151 1755 2802138 YIL048W NEO1
SGTC_2507 purpurin 79.67 µM 0.362650653556257 0.312132656203227 no 1079 0.358432933190388 1594 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_101 0490-5701 117.494 µM 0.362527194309144 0.312177574381033 no 1080 0.358479052753435 1775 4661669
SGTC_1904 st060225 78 µM 0.362157998991052 0.312311915371113 no 1081 0.358616982049225 1664 66595
SGTC_997 3996-0078 137 µM 0.360793027092032 0.312808811253999 no 1082 0.359127087895883 1678 735687
SGTC_1596 piperlongumine 63 µM 0.359359314685355 0.313331097498338 no 1083 0.359663153428346 1805 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1705 st027868 56.3335 µM 0.357292079712385 0.314084828617761 no 1084 0.360436579346397 1785 292948
SGTC_2266 7929956 200 µM 0.350869929702879 0.316431338234012 no 1085 0.362842965832366 1657 2967153
SGTC_539 4859-0462 2.54 µM 0.348408736706238 0.317332572212605 no 1086 0.363766621070349 1829 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1828 st055811 49 µM 0.348309868775621 0.317368798127752 no 1087 0.363803741567091 1830 5877589
SGTC_2486 5283202 22.39 µM 0.3451104434274 0.318542033118157 no 1088 0.365005671257275 1645 1377751
SGTC_1579 chlormadinone acetate 49.4 µM 0.343928974526775 0.318975741097953 no 1089 0.365449850541815 1825 45114258 A steroidal progestin.
SGTC_3289 9119912 71.43 µM 0.343224512446713 0.319234461658929 no 1090 0.365714782614542 1739 17014829
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.342108064674573 0.319644668307306 no 1091 0.366134784256329 1846 6728940
SGTC_3063 1327-0034 4 µM 0.341728563554976 0.319784155382174 no 1092 0.366277587096913 1767 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_159 3970-0959 50 µM 0.341062249610417 0.320029123256296 no 1093 0.366528359805734 1767 6615653
SGTC_1230 0170-0365 3.77 µM 0.340121871912281 0.320374983199058 no 1094 0.36688237561086 1791 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_112 phenothiazine 287.218 µM 0.337425840098828 0.32136741658516 no 1095 0.367897954038032 1870 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2050 5263056 171 µM 0.332376512754567 0.323229549771625 no 1096 0.369802485753859 1854 763468 YGL055W OLE1
SGTC_3138 9097216 49.47 µM 0.332353495528628 0.323238048452093 no 1097 0.369811174868992 1820 25237486
SGTC_3042 9091578 49.47 µM 0.328778449828096 0.324559184827274 no 1098 0.371161576456891 1765 25236497
SGTC_307 1501-1223 22.3 µM 0.328704920012078 0.324586380580759 no 1099 0.371189367586833 1739 2830329
SGTC_1322 1348-1070 12 µM 0.328010585134218 0.324843233527907 no 1100 0.371451829615561 1824 6758089
SGTC_1546 5-methoxyflavanone 78.7 µM 0.327652720222787 0.324975649818274 no 1101 0.371587127681248 1862 147795
SGTC_205 1486-1330 71.903 µM 0.325798305132556 0.325662169784195 no 1102 0.372288480570397 1764 4118834
SGTC_2645 abamectin 100 µM 0.324870222087024 0.326005976218188 no 1103 0.372639647418298 1822 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1317 1273-0028 910 nM 0.323549324897733 0.326495554964435 no 1104 0.373139629312753 1728 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_285 1486-1325 46 µM 0.322725379688506 0.326801094389766 no 1105 0.373451614778094 1812 22310230
SGTC_677 0929-0063 136 µM 0.322521123777013 0.326876855551509 no 1106 0.373528968775855 1721 1539583
SGTC_1148 3909-7663 27.7 µM 0.322382344313594 0.326928334723259 no 1107 0.373581529018186 1841 4084526
SGTC_712 r015-0009 80.6 µM 0.322242651602811 0.326980155983626 no 1108 0.373634437511502 1814 6813872 YLR060W FRS1
SGTC_326 k292-0812 17.5 µM 0.322110341216427 0.327029241728678 no 1109 0.373684552152108 1860 3579357
SGTC_408 cantharidin 100 µM 0.320062851406372 0.327789219678425 no 1110 0.374460342914633 1779 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1134 3477-0009 42.5 µM 0.319933985676102 0.32783707538296 no 1111 0.374509186984868 1906 3973534
SGTC_3077 9117319 49.47 µM 0.319790441005483 0.327890385602057 no 1112 0.374563597195328 1773 17154678
SGTC_1937 st074714 47.2 µM 0.319425234430555 0.328026033355397 no 1113 0.374702038996482 1649 17250970
SGTC_84 0443-0269 128.823 µM 0.317512388000487 0.328736887317908 no 1114 0.375427420571769 1817 6150058
SGTC_2357 9067248 200 µM 0.312972446966422 0.33042650355463 no 1115 0.377150797723962 1778 9150235
SGTC_1647 st011722 22.4 µM 0.307779175220244 0.332363513583322 no 1116 0.379125184332303 1802 2854783
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.307545922613958 0.332450618842532 no 1117 0.379213937165943 1824 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2082 5219693 150 µM 0.307418776790497 0.33249810366604 no 1118 0.379262318951552 1715 2834649
SGTC_2686 alizarin 95.37 µM 0.307085846306582 0.332622455090626 no 1119 0.379389015289339 1706 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2338 7999974 200 µM 0.305403918727598 0.333250945913619 no 1120 0.380029268781261 1944 315925
SGTC_2192 5915882 198.485 µM 0.304962543550379 0.333415953551166 no 1121 0.380197340084418 1786 2876149
SGTC_1854 st056233 32.9 µM 0.304700125642347 0.333514073489403 no 1122 0.380297276955227 1907 5393174
SGTC_660 4031-1742 102 µM 0.304678501099776 0.333522159569069 no 1123 0.380305512607581 1762 6738706
SGTC_13 0199-0087 65 µM 0.303909492133359 0.333809765864759 no 1124 0.380598422976921 1817 4589825
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.303868292645149 0.333825177067295 no 1125 0.380614117519907 1779 521171
SGTC_2145 5634607 200 µM 0.303832890147823 0.333838420054184 no 1126 0.380627603912747 1711 308662
SGTC_1429 4049-0205 9.46 µM 0.303520725455494 0.33395520023426 no 1127 0.380746527667319 1800 22774478
SGTC_1486 3970-0793 4.53 µM 0.295601733738345 0.33692303080152 no 1128 0.383767124723238 1900 2844330
SGTC_1989 st071868 50.2 µM 0.295423261648351 0.336990035461411 no 1129 0.383835282814467 1921 16414057
SGTC_366 0181-0206 4.31 µM 0.294147642693629 0.3374690979028 no 1130 0.384322543353592 1945 274874
SGTC_2640 pentamidine 10.38 µM 0.29404663372965 0.337507043386568 no 1131 0.384361134549617 1933 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_371 0195-0006 7.36 µM 0.293647606136764 0.337656960048549 no 1132 0.384513597095542 1712 3928593
SGTC_2421 5690543 90.72 µM 0.291954069042813 0.338293516884374 no 1133 0.385160871140937 1807 3397993
SGTC_3008 9078912 71.4286 µM 0.291074591210988 0.338624272441624 no 1134 0.385497136125406 1778 16648731
SGTC_1614 st002383 48.6 µM 0.290256444882988 0.338932074134501 no 1135 0.385810028545366 1815 1947235
SGTC_1126 isoteolin 1.0172 µM 0.290223664734021 0.338944408871847 no 1136 0.385822566556737 1709 133323
SGTC_196 k015-0023 18.111 µM 0.288541741867967 0.339577525706279 no 1137 0.386466041549711 1793 5211998
SGTC_1523 st012844 44.7 µM 0.287782513530702 0.339863466286846 no 1138 0.38675661178202 1791 4274103
SGTC_779 1360-0071 233 µM 0.287614388003716 0.339926798193249 no 1139 0.38682096501358 1942 7566
SGTC_3254 9136651 49.47 µM 0.286950047049562 0.340177095742403 no 1140 0.387075284530354 1784 16454030
SGTC_2396 5342950 42.78 µM 0.284718076415943 0.341018529871231 no 1141 0.387930070309805 1789 1886677
SGTC_3166 9102297 49.47 µM 0.284528177565896 0.341090156724444 no 1142 0.388002821689113 1757 25237072
SGTC_1157 4092-0394 27.6 µM 0.284206400377385 0.341211539081116 no 1143 0.388126105417056 1889 3659885
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.282196901620011 0.34196994328719 no 1144 0.38889626698396 1847 676296 Flavone; oxidizing agent.
SGTC_1534 6-azauridine 81.6 µM 0.280292524838249 0.342689262456963 no 1145 0.389626542672683 1813 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_447 ml7 120 µM 0.277505504212335 0.343743001299873 no 1146 0.390695989988126 1908 4216 Selective myosin light chain kinase inhibitor.
SGTC_1602 st001878 87.6 µM 0.277121067745015 0.343888447635604 no 1147 0.390843572684576 1889 595405 YLR310C CDC25
SGTC_767 0929-0023 86 µM 0.275523333090769 0.344493176274542 no 1148 0.39145710102222 1803 1204563
SGTC_3182 9108849 49.47 µM 0.27414244600225 0.345016150474365 no 1149 0.391987577821894 1842 17133045
SGTC_2037 5169046 200 µM 0.273263588909424 0.34534914849526 no 1150 0.392325301172614 1861 5718022
SGTC_2731 amoxapine 43.43 µM 0.271831205694872 0.34589213351754 no 1151 0.392875904846619 1929 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2132 5317594 122.667 µM 0.271412518652545 0.346050908519219 no 1152 0.393036887395519 1856 794577
SGTC_1745 st081495 74 µM 0.270375795938497 0.346444172194427 no 1153 0.39343557947292 1832 13842402 YBL026W LSM2
SGTC_221 trifluoperazine 10.304 µM 0.269644551275849 0.346721657419052 no 1154 0.393716861212443 1839 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1026 k007-1105 30.6 µM 0.269539530971967 0.346761516204594 no 1155 0.393757263048619 1806 7066794
SGTC_1449 4112-4002 201 µM 0.269444200332091 0.346797698900948 no 1156 0.39379393821286 1777 2059539
SGTC_1501 4491-0275 38.4 µM 0.267911117784736 0.347379771328573 no 1157 0.394383867842539 1952 5104718
SGTC_796 1234-0020 70.7 µM 0.267843861494611 0.347405315085697 no 1158 0.39440975359811 1788 46495034
SGTC_2414 st077232 92.9 µM 0.266820450312602 0.347794089331462 no 1159 0.394803703917381 1717 729801
SGTC_2485 5633444 17.78 µM 0.265060942086414 0.348462866747671 no 1160 0.395481257577013 1752 5724239
SGTC_3203 9113543 49.47 µM 0.264836785280134 0.348548101154998 no 1161 0.395567598903164 1870 17018012
SGTC_1154 4088-0362 150 µM 0.26287622598617 0.349293918675621 no 1162 0.396322990476957 1813 6618304
SGTC_2442 5158906 48.48 µM 0.262757621206257 0.34933905589791 no 1163 0.396368700696128 1930 1893835
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.261954431286096 0.349644780585367 no 1164 0.39667828712265 1792 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2817 7995342 71.43 µM 0.261740359323288 0.349726281001847 no 1165 0.396760811329701 1768 18879975
SGTC_603 3794-0023 45.9 µM 0.261570204172452 0.349791066567786 no 1166 0.396826409014016 1956 3802260
SGTC_756 0508-1999 28.3 µM 0.260918143038643 0.350039375464838 no 1167 0.397077816610446 1739 6753853
SGTC_1663 st014140 55.4 µM 0.260869000471072 0.350058091857523 no 1168 0.397096765670988 1898 4207120
SGTC_2870 9038528 12.99 µM 0.260096846868297 0.350352221361503 no 1169 0.397394535042102 1842 6463316
SGTC_3051 9093778 49.47 µM 0.259946166047796 0.350409629319916 no 1170 0.3974526498036 1899 17217378
SGTC_2238 6671620 73.2395 µM 0.259542202507708 0.350563552442131 no 1171 0.397608462179748 1756 729941
SGTC_2176 5809774 33.9695 µM 0.259355579247401 0.350634670204545 no 1172 0.397680449970799 1987 2870539
SGTC_1161 k007-0610 110 µM 0.257140732705955 0.351479095574962 no 1173 0.398535067145314 1975 5843850
SGTC_1290 0986-0249 10.2 µM 0.25700278524228 0.35153171329508 no 1174 0.398588311481493 1949 53329
SGTC_3290 9121031 71.43 µM 0.256805945181079 0.351606799523356 no 1175 0.398664290183614 1812 17014854
SGTC_963 1269-2853 151 µM 0.253970991111889 0.352688856490507 no 1176 0.39975898460231 1783 3668223
SGTC_150 3970-0969 77.2 µM 0.253896363968386 0.352717356638227 no 1177 0.399787811952769 1879 6615640
SGTC_82 0054-0107 293.755 µM 0.253360921072355 0.352921866812632 no 1178 0.399994661552728 1983 3104697
SGTC_2375 9072683 200 µM 0.252838842431575 0.353121313489022 no 1179 0.400196375362693 2013 16798029
SGTC_1715 st032160 10.2275 µM 0.252820926813078 0.35312815840537 no 1180 0.400203297834239 1939 5289825
SGTC_3122 9126309 49.47 µM 0.252458464593594 0.353266652444873 no 1181 0.400343357469841 1998 17591206
SGTC_2915 7971052 15.16 µM 0.252260600226278 0.353342263106447 no 1182 0.400419819981793 1957 5741558
SGTC_789 1309-1135 70.6 µM 0.248636918647531 0.354728015348359 no 1183 0.401820824066857 1782 3092424
SGTC_2318 6029776 164 µM 0.247940382933159 0.354994602533942 no 1184 0.40209026707343 1910 818325
SGTC_179 1273-0063 6.77 µM 0.247148959610401 0.355297592505898 no 1185 0.402396472210194 1809 3108139
SGTC_3113 9123498 49.47 µM 0.246791912490764 0.355434315048538 no 1186 0.402534634916868 2008 8897275
SGTC_2429 5902844 64.44 µM 0.245869454354314 0.355787634136644 no 1187 0.402891644999853 1999 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1415 3966-0071 78.1 µM 0.245530429985718 0.355917518102975 no 1188 0.403022874699489 1897 2893185
SGTC_948 3448-0295 75.3 µM 0.245297223438995 0.356006871807589 no 1189 0.40311315073331 1853 678569
SGTC_3311 9131146 2.8755 µM 0.243999722951206 0.35650415684878 no 1190 0.40361551724392 1878 4900406 YPR165W RHO1
SGTC_92 0063-0024 660.874 µM 0.243948318334936 0.356523863411802 no 1191 0.403635423375113 2001 3594437
SGTC_2890 9046729 58.44 µM 0.243348616442587 0.356753794460707 no 1192 0.40386767278818 1804 903329
SGTC_2744 captopril 92.04 µM 0.242591480843831 0.357044161338876 no 1193 0.404160940705836 1988 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_237 nikkomycin 200 µM 0.241664361215691 0.35739983109242 no 1194 0.40452012337037 1967 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_667 1498-1044 59 µM 0.240633943260087 0.357795274435657 no 1195 0.40491942007029 1881 6739982
SGTC_719 2810-4230 27.3 µM 0.239295100141904 0.358309310069619 no 1196 0.405438382289925 1904 721079
SGTC_3291 9121177 71.43 µM 0.238916670325975 0.358454651080255 no 1197 0.405585099395065 1856 17015612
SGTC_2563 tomatine 8.54 µM 0.236592086423209 0.359347887638304 no 1198 0.406486630024012 2104 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_171 k064-0041 9.68 µM 0.23611947364855 0.359529586438075 no 1199 0.406669981661535 1820 53325
SGTC_1439 4092-1168 46 µM 0.23518069246331 0.359890600637623 no 1200 0.407034245477328 1928 2886240
SGTC_742 0kpi-0133 140 µM 0.234762955172363 0.360051284350916 no 1201 0.407196360860793 2000 2728852
SGTC_2836 9010338 19.48 µM 0.233853660163578 0.360401132465184 no 1202 0.407549294774586 1748 2994051
SGTC_1460 k062-0059 9.15 µM 0.231906644050307 0.361150633039746 no 1203 0.408305261995056 1828 1373085
SGTC_481 bay k-8644 50 µM 0.230932332819962 0.361525892923241 no 1204 0.408683685794633 1849 2303 A calcium channel antagonist.
SGTC_3046 9092212 49.47 µM 0.229746386872906 0.361982844538845 no 1205 0.409144423680332 1914 25236637
SGTC_1377 2944-0135 198 µM 0.229490277854352 0.36208155064039 no 1206 0.409243938082837 1890 1894137
SGTC_1801 st050089 28.441 µM 0.228907897208242 0.362306038111251 no 1207 0.409470251221057 1913 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1246 0422-0085 105 µM 0.227592595890287 0.362813215160545 no 1208 0.409981488266698 2023 264295
SGTC_2576 guaiol 23.12 µM 0.22718153442453 0.362971768900351 no 1209 0.410141292859914 2048 227829
SGTC_596 1155-0152 116 µM 0.227130521965774 0.362991446954678 no 1210 0.41016112554678 1859 280313
SGTC_1747 st037496 66.6 µM 0.226660215173331 0.363172884819564 no 1211 0.410343982822701 1887 723305
SGTC_2715 st079500 56.4 µM 0.226295250855551 0.363313704176743 no 1212 0.410485895932722 1871 28246688
SGTC_3220 9131269 49.47 µM 0.226119929139434 0.363381357610757 no 1213 0.410554072382406 1949 17722206
SGTC_1959 st077091 55.8 µM 0.225266881722675 0.363710593737792 no 1214 0.410885831055246 1884 821356 YKL052C ASK1
SGTC_1308 1187-1617 41.4 µM 0.223641348544608 0.364338251488225 no 1215 0.411518193480758 1887 2882570
SGTC_124 0136-0217 7.121 µM 0.223354718885128 0.364448963940413 no 1216 0.411629721602877 2078 3976905
SGTC_2339 9000433 200 µM 0.222252800265523 0.364874691955482 no 1217 0.412058546555644 1834 2988954
SGTC_309 k408-0051 1.48 µM 0.22178173230911 0.365056740692157 no 1218 0.412241900423447 1932 3640463
SGTC_2269 7935389 174.42 µM 0.221523629787304 0.365156499793406 no 1219 0.412342369841778 1831 97605
SGTC_318 1488-0629 67.2 µM 0.220115495294025 0.365700917839536 no 1220 0.412890603621635 1899 3662576
SGTC_1878 temozolomide 1 mM 0.218406844316799 0.366361885990999 no 1221 0.413556066633383 2060 5394 DNA alkylating agent.
SGTC_2846 9008642 19.48 µM 0.218061705260156 0.366495446506187 no 1222 0.413690517087632 1881 2992898
SGTC_1401 3807-4679 7.6 µM 0.217643684588817 0.366657232104884 no 1223 0.413853372447775 1909 3291456
SGTC_22 0964-0034 14.468 µM 0.217173442368527 0.36683925720965 no 1224 0.414036590345147 1928 138402
SGTC_1790 st045711 43.5 µM 0.216827918275276 0.366973024516273 no 1225 0.414171226930688 2047 585119
SGTC_2662 daunorubicin 22.37 µM 0.216240207671627 0.367200589782046 no 1226 0.414400256841275 1975 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_361 000s-0510 1.45 µM 0.213624335822208 0.36821403691847 no 1227 0.415420010104568 1912 660
SGTC_2967 9089538 49.85 µM 0.213607445068105 0.368220583763092 no 1228 0.41542659653785 2066 728216
SGTC_2234 tolnaftate 200 µM 0.212397803312076 0.368689539468252 no 1229 0.41589834969422 2024 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_958 1222-0007 33 µM 0.209441679760259 0.369836395690229 no 1230 0.41705172921829 1989 7312461
SGTC_1483 3453-0561 55.9 µM 0.209146603679952 0.369950937026736 no 1231 0.417166897302937 2003 4546991
SGTC_2800 7887935 81.82 µM 0.208788474709582 0.370089969454993 no 1232 0.417306684454457 1945 2961002
SGTC_2630 antimycin a 100 µM 0.208646102947116 0.370145245578666 no 1233 0.417362258800611 1928 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1719 st032227 49.2 µM 0.20853804767899 0.370187200044661 no 1234 0.41740443891882 1871 3125804
SGTC_58 0957-0393 9 µM 0.208425420529055 0.370230931272683 no 1235 0.417448404714233 1912 6997992
SGTC_2463 5473429 200 µM 0.208393562970278 0.370243301331315 no 1236 0.417460841005171 1927 5399405
SGTC_2721 ifenprodil 61.44 µM 0.207272531257131 0.370678675165528 no 1237 0.417898512598261 2025 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_104 0074-0074 590.992 µM 0.206220206012356 0.371087516298481 no 1238 0.418309452469747 2049 3943124
SGTC_2200 6600604 21.907 µM 0.205195246583025 0.371485865406478 no 1239 0.418709791554624 1953 2904777
SGTC_3130 9127414 49.47 µM 0.20122047497149 0.373031953750314 no 1240 0.420263091101962 2096 1494646
SGTC_1759 st043059 70 µM 0.199674750275671 0.373633756839398 no 1241 0.420867481223899 1879 669426
SGTC_1510 1123-0200 71.5 µM 0.19842990652622 0.374118640941776 no 1242 0.42135436030004 2042 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2125 5246583 200 µM 0.194733456017304 0.375559631694109 no 1243 0.422800809575972 2100 835267
SGTC_2549 cedrol 20.94 µM 0.193530341242635 0.37602901886972 no 1244 0.423271823158005 2063 6708665 A sedative which affects the nervous system.
SGTC_2959 9079155 11 µM 0.192526925128217 0.376420635300268 no 1245 0.423664739599235 1965 16189457
SGTC_947 3447-0010 211 µM 0.191677848004118 0.376752115228691 no 1246 0.423997279480878 2040 748350
SGTC_1597 7-benzyloxygramine 47.5 µM 0.19098667000675 0.377022018412709 no 1247 0.424268018361279 1916 260807
SGTC_1242 0402-0103 60.1 µM 0.19028379167777 0.37729655218223 no 1248 0.424543376990461 1991 432868
SGTC_3319 9138450 16.7555 µM 0.190147848055142 0.37734965689161 no 1249 0.424596638328204 1951 2029690
SGTC_3188 9110789 49.47 µM 0.18905139973747 0.377778055692308 no 1250 0.42502626595214 2071 849217
SGTC_2481 5478948 45.16 µM 0.188966892133041 0.377811080328875 no 1251 0.42505938275396 1948 77792
SGTC_286 k060-0067 22.9 µM 0.188746437024433 0.377897235948811 no 1252 0.425145777090991 1993 5985051
SGTC_1268 0828-0275 2.46 µM 0.187886448005568 0.378233384561234 no 1253 0.425482833235103 2018 745337
SGTC_3337 9144342 33.5465 µM 0.18708661645457 0.378546101843834 no 1254 0.425796360706859 2026 17682949
SGTC_733 4069-0007 56.1 µM 0.183423301562277 0.379979394450658 no 1255 0.427232947004677 2025 5717425 YNL287W SEC21
SGTC_664 1222-0054 14.9 µM 0.183341376354401 0.380011467086223 no 1256 0.427265085471542 2006 6813991
SGTC_2814 7977482 42.97 µM 0.183150336884661 0.380086259717902 no 1257 0.427340030283183 2057 6456762
SGTC_1977 st070720 65.3 µM 0.182980039682503 0.380152935458853 no 1258 0.427406840110997 1954 682188
SGTC_483 fpl-64176 144 µM 0.18242618986238 0.380369806548125 no 1259 0.427624137051498 2086 3423
SGTC_2437 5741531 144.16 µM 0.182270410488837 0.380430811889502 no 1260 0.427685259349881 2085 2262990
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.181897393371114 0.380576902597785 no 1261 0.427831625081155 1972 6312947
SGTC_215 1287-0124 461.5 µM 0.181895886468933 0.380577492804739 no 1262 0.427832216384737 2097 5560863
SGTC_3180 9109287 49.47 µM 0.181213693178229 0.380844715333366 no 1263 0.428099923468656 1991 18891271
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.179497874107551 0.381517071353092 no 1264 0.428773393219582 1953 279621
SGTC_1316 1272-0050 65.9 µM 0.178833377515298 0.381777555311748 no 1265 0.4290342681342 2010 7340392
SGTC_125 0133-0007 11.75 µM 0.178536586666677 0.381893915206516 no 1266 0.429150795364148 2113 26541
SGTC_911 3456-4043 236 µM 0.178024177490422 0.382094835587268 no 1267 0.429351994066192 2035 914281
SGTC_1084 voriconazole 435 nM 0.177801344310835 0.382182220450592 no 1268 0.429439495782442 2113 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_924 2046-0044 21.3 µM 0.176764420792767 0.382588932755522 no 1269 0.429846718504993 2124 3623589
SGTC_2188 6126565 140.678 µM 0.173566067257891 0.383844236459263 no 1270 0.431103250799129 2085 874518
SGTC_2990 9074105 71.4286 µM 0.172248317646145 0.38436178814492 no 1271 0.431621156752774 2064 6502001
SGTC_706 4262-0057 46.9 µM 0.172068441457515 0.384432451288721 no 1272 0.431691861377556 2004 883298
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.17204242396136 0.384442672404047 no 1273 0.431702088355975 2111 279621
SGTC_587 k089-0003 57 µM 0.172020972246186 0.384451099887832 no 1274 0.431710520647947 2115 9659696
SGTC_723 4182-0001 115 µM 0.170016479646042 0.385238821859724 no 1275 0.432498588223861 1956 744821 YLR208W SEC13
SGTC_827 3253-0474 693 µM 0.170011940990251 0.385240605991449 no 1276 0.432500372905307 2109 5402065
SGTC_260 nsc-65238 3.989 µM 0.166886205406921 0.386469898036786 no 1277 0.433729793710358 2074 3246252
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.166573257157245 0.386593037599149 no 1278 0.433852918685987 2095 229346 A bile salt which induces apoptosis.
SGTC_2034 5197015 53.07 µM 0.165850655909239 0.386877411928668 no 1279 0.434137240226949 2092 780676
SGTC_565 1418-0001 44.5 µM 0.165583219314828 0.386982675013328 no 1280 0.434242477013392 2089 2862145
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.165320045715914 0.387086268297653 no 1281 0.434346040852857 1932 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_340 k038-0059 454 µM 0.162725250792133 0.388108089489525 no 1282 0.435367382359006 2038 23733424
SGTC_656 4090-1979 187 µM 0.162533694760053 0.388183554395483 no 1283 0.435442798223261 2128 22330961
SGTC_2822 7994718 71.43 µM 0.161985182488582 0.388399668179098 no 1284 0.435658761211904 2106 1018011
SGTC_2909 7941780 10.49 µM 0.161243846972681 0.388691809203305 no 1285 0.435950674012513 2137 1243215
SGTC_2620 irigenin 100 µM 0.160350765181222 0.389043833086232 no 1286 0.43630238568091 2074 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1481 3346-2004 36 µM 0.160348987244426 0.389044533982224 no 1287 0.43630308591472 2127 2770522
SGTC_1412 3909-8563 178 µM 0.15994163149535 0.389205130763994 no 1288 0.436463526723197 2139 23767530
SGTC_2869 9037858 32.47 µM 0.159675840388315 0.389309927011584 no 1289 0.436568216632527 2160 27187042
SGTC_2897 9048598 12.99 µM 0.15808463544671 0.389937476202925 no 1290 0.437195053753724 2027 6467404
SGTC_1762 st045503 25.4615 µM 0.156760079406582 0.390460081723334 no 1291 0.437716967905634 1995 4645554
SGTC_2512 diallyl trisulfide 49.23 µM 0.156286898615765 0.390646823938973 no 1292 0.437903441416005 2150 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2128 5255449 168.493 µM 0.153502259920116 0.391746299630042 no 1293 0.439001104135564 2065 736008
SGTC_762 1165-0429 115 µM 0.152125561164349 0.392290190069916 no 1294 0.439543951970494 2147 5967793
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.15168147940761 0.39246567777314 no 1295 0.439719082714102 2102 616764
SGTC_1812 st052057 4.327 µM 0.151047306039982 0.392716321846269 no 1296 0.439969199569014 2083 3645418
SGTC_130 0136-0219 337.655 µM 0.150717228586827 0.392846795832898 no 1297 0.440099391019939 2165 234244
SGTC_2274 7947094 46.08 µM 0.150284496729604 0.393017865592183 no 1298 0.440270081946337 2184 2971028
SGTC_775 4577-0580 57.3 µM 0.148000350596078 0.393921187514351 no 1299 0.441171245776994 2091 2006902
SGTC_1253 0550-0034 176 µM 0.147720344968573 0.394031962034153 no 1300 0.44128173741275 2031 5969915
SGTC_2854 9024559 71.43 µM 0.147365542563941 0.394172339619748 no 1301 0.441421750798338 2012 3163529
SGTC_2417 cerulenin 830 nM 0.147238509082568 0.394222603765153 no 1302 0.441471882982851 2181 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_745 0469-0705 296 µM 0.146918803131351 0.394349111646034 no 1303 0.441598055110606 2143 3486736
SGTC_2223 6903751 107.57 µM 0.146271133685751 0.39460542907012 no 1304 0.4418536763611 2108 5598863
SGTC_1761 st044296 37 µM 0.146074489581948 0.394683260690689 no 1305 0.441931292372239 2094 1826700
SGTC_1687 st020778 55.3625 µM 0.145871568655096 0.394763581081385 no 1306 0.442011388201435 2065 4259299
SGTC_2449 5812982 45.77 µM 0.145728712072464 0.394820129418749 no 1307 0.4420677771862 2135 776185
SGTC_2087 5276107 200 µM 0.143279292240322 0.395790051323473 no 1308 0.443034804741786 2118 144405
SGTC_3053 9095903 49.47 µM 0.142579374981581 0.39606732361235 no 1309 0.443311193709213 2175 17174018
SGTC_2958 9077254 16.72 µM 0.13880024057228 0.397565333270727 no 1310 0.444804001938356 2056 16457351
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.138171140402801 0.397814849430628 no 1311 0.445052581460596 2067 6708514
SGTC_2610 ononetin 44.17 µM 0.135095034200366 0.399035506817771 no 1312 0.4462683681604 2044 259632
SGTC_1267 0828-0272 9.49 µM 0.133672926614088 0.399600160829293 no 1313 0.446830607214646 2154 745334
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.133139867206568 0.399811868577249 no 1314 0.447041383159912 2169 165521
SGTC_2728 chlorpromazine 9.18 µM 0.133040076188213 0.39985150445506 no 1315 0.44708084298938 2185 2726 A thorazine and dopamine antagonist.
SGTC_2390 9097792 176.6 µM 0.13094498685705 0.400683888183921 no 1316 0.447909413338358 2007 4497149
SGTC_1736 st036774 51 µM 0.128586839891914 0.401621324882427 no 1317 0.44884229004808 2203 1272247
SGTC_572 0960-0087 17.7 µM 0.128186265495583 0.401780622081169 no 1318 0.449000784472359 2114 6796365
SGTC_2161 5662504 8.5105 µM 0.121851423132242 0.404301964377485 no 1319 0.451508343786168 2072 2859334
SGTC_2213 7173844 200 µM 0.121263749230801 0.40453606888774 no 1320 0.451741066001609 2168 892728
SGTC_85 0868-0259 160.055 µM 0.120509666077123 0.404836513888545 no 1321 0.452039711513395 2127 83173
SGTC_1334 1486-0610 236 µM 0.119611042816663 0.405194620429243 no 1322 0.452395635814466 2132 3742339
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.119277053108831 0.405327737502823 no 1323 0.452527931333332 2233 16623 A steroid.
SGTC_998 3996-0085 177 µM 0.119270071996498 0.405330520056503 no 1324 0.452530696654104 2157 715391
SGTC_1053 3366-3204 134 µM 0.118861092816219 0.405493540609409 no 1325 0.452692703307421 2075 3632071 YPR165W RHO1
SGTC_1262 0737-0114 49.6 µM 0.116757651462582 0.406332238208167 no 1326 0.453526051691724 2211 765919
SGTC_1638 st008370 60.6 µM 0.116117013807789 0.406587762946244 no 1327 0.453779902478222 2197 24207134
SGTC_3300 9124615 50.48 µM 0.115676057152377 0.406763666040446 no 1328 0.453954641234783 2170 24824903
SGTC_2946 9065502 71.43 µM 0.114063935624149 0.407406921227011 no 1329 0.45459355539567 2227 16489101
SGTC_2403 6032726 181.2 µM 0.113461857752185 0.407647221432978 no 1330 0.454832200432391 2123 2881040
SGTC_658 3253-0951 102 µM 0.112362883631238 0.408085931498306 no 1331 0.455267841742574 2131 1184878
SGTC_431 k089-0097 107 µM 0.110892593287669 0.408673051018206 no 1332 0.455850759538607 2217 5499420
SGTC_2726 cimetidine 79.27 µM 0.107623300491732 0.409979285034639 no 1333 0.457147256611702 2216 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2251 lansoprazole 556 µM 0.107039527063668 0.410212635177746 no 1334 0.457378810905964 2016 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2778 tioconazole 65.09 nM 0.106790126682128 0.4103123370031 no 1335 0.457477740224128 2200 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_296 1222-0039 74.9 µM 0.106269330115033 0.410520552516259 no 1336 0.457684332395519 2122 5984176
SGTC_1657 st012939 43.4 µM 0.105283891351511 0.41091460188087 no 1337 0.458075272384871 2203 24207257
SGTC_3346 9158254 43.5805 µM 0.103461251882315 0.411643661036849 no 1338 0.458798450465892 2144 17639500
SGTC_1431 4049-0260 9.09 µM 0.102388514910922 0.412072900629403 no 1339 0.459224149767511 2188 3854841
SGTC_1810 st050138 53 µM 0.101724129839736 0.412338797134626 no 1340 0.459487824326076 2240 3444541
SGTC_207 4185-0010 4.486 µM 0.100292545889297 0.412911874337556 no 1341 0.460056037587222 2234 3761753
SGTC_1737 st035557 69.7 µM 0.0986450591586868 0.413571609253574 no 1342 0.460710046216229 2249 5716916
SGTC_2204 7233102 200 µM 0.0985345058480168 0.413615889008974 no 1343 0.46075393677996 2181 2172480
SGTC_60 0986-0278 202 µM 0.0965447207143071 0.414413042020743 no 1344 0.461543978894983 1978 3110598
SGTC_1349 flufenamic acid 69 µM 0.0949607850365636 0.415047854816117 no 1345 0.462172987559984 2206 3371 A non-steroidal anti-inflammatory.
SGTC_1042 0350-0096 82 µM 0.0942983465262003 0.41531341409442 no 1346 0.46243608167247 2054 3122515
SGTC_2601 securinine 100 µM 0.0942013784378185 0.415352290046758 no 1347 0.462474594905094 2168 442872 A GABA receptor antagonist.
SGTC_1669 st015249 58.4 µM 0.0932958644521866 0.415715364055857 no 1348 0.462834258722038 2265 722793
SGTC_1213 1315-0166 115 µM 0.0927465929190359 0.415935634521541 no 1349 0.46305244035508 2007 768401
SGTC_1511 0906-3109 28.5 µM 0.0922422659448325 0.416137904449643 no 1350 0.463252778900502 2243 2882180
SGTC_1652 st011932 78 µM 0.0914814775563832 0.416443075121796 no 1351 0.463555011642662 2232 1551076
SGTC_2511 berberine 10.47 µM 0.0912851211904678 0.416521846607423 no 1352 0.463633020097273 2197 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_29 0299-0004 12.984 µM 0.0908757621953974 0.416686078268899 no 1353 0.463795654726458 2226 16871 A napthoquinone isolated from Swertia calycina.
SGTC_458 nppb 133 µM 0.0905472600643151 0.416817881301376 no 1354 0.463926170031307 2243 4549 A chloride channel blocker.
SGTC_1131 3454-3128 32.3 µM 0.0898312290686825 0.417105202709964 no 1355 0.464210665649511 2160 710982
SGTC_3002 9075603 71.4286 µM 0.0897817574226051 0.417125055810264 no 1356 0.464230322552278 2261 20105405
SGTC_2465 5809242 33.21 µM 0.0891648762445565 0.417372629562237 no 1357 0.464475439427634 2238 2731748
SGTC_200 k038-0079 37.545 µM 0.0883959415621259 0.417681273009972 no 1358 0.464780993417559 2199 3436683
SGTC_1016 4226-1401 38 µM 0.0859864379414942 0.418648753653262 no 1359 0.465738599124325 2258 2901613
SGTC_2305 7443522 69.23 µM 0.0857920225223688 0.418726838224463 no 1360 0.465815874101347 2187 5415886
SGTC_1391 3442-0225 151 µM 0.085668387685098 0.418776496308025 no 1361 0.465865016343425 2198 5227075
SGTC_3324 9138759 60.749 µM 0.0852479397168148 0.418945379428546 no 1362 0.46603213943975 2196 45595710
SGTC_508 roscovitine 141 µM 0.0849304647934888 0.419072910828488 no 1363 0.466158335939 2259 160355 A CDKinase inhibitor.
SGTC_681 1642-0006 26.6 µM 0.0839364238151014 0.419472277422172 no 1364 0.466553489856756 2270 4446530
SGTC_2867 9039098 71.43 µM 0.0832568917951217 0.419745334447494 no 1365 0.466823638301274 2276 6463460
SGTC_1037 k284-1091 78.7 µM 0.0831639393436594 0.419782688630699 no 1366 0.466860592806501 2249 3334711
SGTC_1780 st038448 24.544 µM 0.0825215816288232 0.420040848389529 no 1367 0.467115978601899 2216 728868 YDL195W SEC31
SGTC_1825 st052143 62.6 µM 0.0823564154540151 0.420107233261747 no 1368 0.4671816468458 2252 674173
SGTC_2100 5377183 190 µM 0.0823108995402347 0.420125527771025 no 1369 0.467199743626659 2215 2844202
SGTC_2329 6138490 200 µM 0.0822884994659684 0.420134531242926 no 1370 0.467208649750577 2127 720019
SGTC_913 3487-1245 167 µM 0.0822519905075608 0.420149205720501 no 1371 0.467223165510297 2206 4016153
SGTC_2135 5326629 150.42 µM 0.0800326920072126 0.421041442340943 no 1372 0.468105627447519 2187 5020077
SGTC_2738 aclarubicin 5.55 µM 0.0797897459851504 0.421139139966869 no 1373 0.468202239920244 2237 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2589 lobaric acid 100 µM 0.0792326845880926 0.421363173384452 no 1374 0.468423773880957 2175 73157 A novel microtubule depolymerizer.
SGTC_731 3966-0296 387 µM 0.0789415892430395 0.421480253350929 no 1375 0.468539541504361 2249 660956
SGTC_965 1291-5240 308 µM 0.0788457256385342 0.42151881167994 no 1376 0.468577666714876 2240 2834598
SGTC_1233 0325-0408 14.2 µM 0.0784373929748752 0.421683059967409 no 1377 0.46874006492508 2228 12874
SGTC_2383 9036125 200 µM 0.0782237072589674 0.421769018634068 no 1378 0.468825052064632 2155 79580
SGTC_2571 chrysanthemic acid 100 µM 0.0780721098233185 0.421830003508179 no 1379 0.468885346298547 2119 2743 An insecticide.
SGTC_391 gliotoxin 8.33 µM 0.0778099730465723 0.421935460759022 no 1380 0.468989606579823 2220 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_834 0312-0008 75.7 µM 0.0767340614448253 0.422368357019838 no 1381 0.469417553649675 2281 6385573 YIL048W NEO1
SGTC_1664 st014217 9.02 µM 0.0752428363937067 0.422968510875567 no 1382 0.47001075120885 2278 3982782
SGTC_3276 9139060 49.47 µM 0.0751108254894931 0.423021648214584 no 1383 0.470063267331207 2301 4870619
SGTC_1400 3771-8998 51.5 µM 0.0750148084995022 0.423060298078559 no 1384 0.470101464805982 2233 670767
SGTC_2019 4016004 108 µM 0.0739247001470591 0.423499152880669 no 1385 0.470535150871751 2202 45595336
SGTC_2864 9034755 47.6 µM 0.0735815562059731 0.423637315114902 no 1386 0.470671673682504 2285 4930451
SGTC_1995 st072814 61.1 µM 0.0719358906610057 0.424300050124351 no 1387 0.471326463704161 2112 5769371
SGTC_154 3389-1638 511.116 µM 0.0717433579216225 0.424377600066599 no 1388 0.471403075205494 2038 5238686
SGTC_406 estrone 100 µM 0.0711212897256823 0.42462818187831 no 1389 0.471650612161688 2286 5870 A steroid.
SGTC_478 N-arachidonylglycine 10 µM 0.0698384345282349 0.425145038312138 no 1390 0.472161127758339 2283 5283389
SGTC_2644 guaiazulene 100 µM 0.0697698505335597 0.425172674118549 no 1391 0.472188422234715 2256 3515 A coloring agent.
SGTC_2313 7726885 200 µM 0.0693340714330368 0.425348279166318 no 1392 0.472361852950341 2227 726423
SGTC_3279 9140807 49.47 µM 0.0690850042903398 0.425448651917185 no 1393 0.472460978675315 2263 45595718
SGTC_2181 6316240 54.2555 µM 0.0685060631600083 0.425681980811234 no 1394 0.47269139685667 2207 12779990
SGTC_3074 9116018 49.47 µM 0.0673632950965216 0.426142623484397 no 1395 0.473146244528831 2264 17027303
SGTC_1018 4259-0013 28.1 µM 0.0665547477231812 0.426468604805631 no 1396 0.473468085953999 2215 6801262
SGTC_257 daunorubicin 18.5 µM 0.0659026222722796 0.426731558251428 no 1397 0.473727676426267 2280 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1179 1021-1431 9.29 µM 0.0650431249729973 0.427078178991445 no 1398 0.474069832083005 2230 2840958
SGTC_115 0527-0192 112.043 µM 0.0650151741633925 0.427089452027553 no 1399 0.474080959290523 2147 4233931
SGTC_1052 3253-3998 198 µM 0.0635857364657552 0.427666047709048 no 1400 0.474650044704456 2284 5450317
SGTC_229 benomyl 22.8748 µM 0.0626127700294413 0.428058603952285 no 1401 0.47503743017924 2213 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_419 nsc-638432 893 µM 0.0623170092859409 0.428177946687137 no 1402 0.475155191675444 2187 368090
SGTC_1673 st016611 27.3 µM 0.0618244761509881 0.428376703835147 no 1403 0.475351305809354 2262 5226799
SGTC_2787 5284540 71.43 µM 0.0616177512805622 0.428460131142826 no 1404 0.47543362016292 2222 736958
SGTC_787 4152-0075 138 µM 0.0612481383224339 0.428609302651361 no 1405 0.475580796414189 2162 9566539
SGTC_2689 tacrolimus 100 µM 0.0610267576599771 0.428698654207867 no 1406 0.475668949617309 2225 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1700 st030840 7.9285 µM 0.0596245429927815 0.429264687448479 no 1407 0.476227335329447 2302 5499307
SGTC_547 1120-0019 610 nM 0.0595020667322122 0.429314134474313 no 1408 0.476276109690789 2292 3676939
SGTC_3084 9116877 49.47 µM 0.0578866206683243 0.42996643786622 no 1409 0.476919470205711 2317 27241325
SGTC_1111 tnp00062 510.699 nM 0.0578490053699703 0.429981628888833 no 1410 0.476934451433904 2296 676306
SGTC_2041 5107442 45.335 µM 0.0571935731471217 0.430246343281087 no 1411 0.477195498833849 2301 793005
SGTC_109 0132-0036 33.701 µM 0.0560102211659619 0.430724351963892 no 1412 0.477666832316062 2294 67274 A color developer.
SGTC_2290 7904846 200 µM 0.054895219864961 0.431174843659271 no 1413 0.478110970066815 2256 2962154
SGTC_1916 st067606 49.2 µM 0.0544822591771225 0.431341714078243 no 1414 0.478275471360117 2272 19590279
SGTC_748 act1.228 77.9 µM 0.0542336969647386 0.431442159768003 no 1415 0.478374486942464 2274 4421505 YNR035C ARC35
SGTC_1329 1447-1697 50.6 µM 0.0534502668667345 0.431758778206633 no 1416 0.478686577627266 2242 2840515
SGTC_227 fluconazole 33.516 µM 0.0533889504428206 0.431783560713535 no 1417 0.478711004463492 2258 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_17 0960-0276 49.807 µM 0.0489970845558031 0.433559331349135 no 1418 0.480460809669159 2324 6821114
SGTC_512 prima-1 270 µM 0.0458506464688841 0.434832363327465 no 1419 0.48171464559209 2322 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_822 1487-0950 154 µM 0.0449481170197263 0.435197647224965 no 1420 0.482074331870017 2342 1958375
SGTC_1155 4088-0394 48.2 µM 0.0447577254545172 0.435274712143249 no 1421 0.482150210750716 2307 2326248
SGTC_3211 9128781 49.47 µM 0.0445602996923287 0.435354626894407 no 1422 0.482228893731483 2154 17194361
SGTC_2482 5981709 142.65 µM 0.0421402370719981 0.436334442620078 no 1423 0.483193452049791 2303 877755
SGTC_471 1-acyl-paf 4 µM 0.0401151208564113 0.437154656186623 no 1424 0.484000673402519 2316 16759367
SGTC_939 1165-0479 45.3 µM 0.0386229146175542 0.437759203389978 no 1425 0.484595516349107 2352 1377347
SGTC_3070 9117005 49.47 µM 0.0385320777526396 0.437796009425292 no 1426 0.484631728059546 2345 8779016
SGTC_701 4424-0219 185 µM 0.0379617136300009 0.438027126583643 no 1427 0.48485910405373 2347 2911779
SGTC_386 1509-0011 3.07 µM 0.0373679143107824 0.438267762375117 no 1428 0.48509582773257 2337 3107280
SGTC_867 0518-0118 155 µM 0.0369805037316056 0.438424771920205 no 1429 0.48525027543731 2340 6848158
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0358265491591107 0.438892503325205 no 1430 0.485710331742258 2344 5355888
SGTC_737 1950-0117 57.9 µM 0.0333647847919784 0.439890612575997 no 1431 0.486691845841645 2352 5393513
SGTC_3047 9092122 49.47 µM 0.032737099428896 0.440145165657267 no 1432 0.48694211933535 2327 17173831
SGTC_2474 5321570 43.32 µM 0.0318405672788272 0.440508790414949 no 1433 0.48729959750742 2325 2841384
SGTC_1152 3909-8331 15.9 µM 0.031540057643194 0.440630685455554 no 1434 0.487419423322094 2316 16001939
SGTC_1214 0358-0031 63.7 µM 0.0311867689850012 0.440773996325079 no 1435 0.487560295801688 2339 4301366
SGTC_1616 st002734 56.1 µM 0.0307829981779882 0.440937794679742 no 1436 0.487721299741587 2264 4026101
SGTC_956 1185-0240 191 µM 0.0293762565879212 0.441508548561349 no 1437 0.488282254564351 2341 1416193
SGTC_2722 naftopidil 47.16 µM 0.0286065118984283 0.441820906722208 no 1438 0.488589209233665 2343 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0276753405829671 0.44219881926259 no 1439 0.488960545766298 2348 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3354 9151612 71.43 µM 0.0275947279593069 0.442231538086241 no 1440 0.488992693272411 2354 27261949
SGTC_442 cape 100 µM 0.0252513715712649 0.443182824279384 no 1441 0.489927230706416 2353 5281787
SGTC_1811 st050069 61.5 µM 0.0251430776624536 0.443226794183603 no 1442 0.489970420012705 2364 3877702
SGTC_2798 7813637 45.45 µM 0.0248176179044746 0.443358942796376 no 1443 0.490100219165351 2342 956368
SGTC_2939 9044578 71.43 µM 0.0244540203194918 0.443506584217135 no 1444 0.49024522960245 2354 2653634
SGTC_1729 st035615 45.989 µM 0.0242872382028457 0.443574309923009 no 1445 0.490311746284339 2220 17385451
SGTC_1852 st056254 31.4 µM 0.0242495533889965 0.443589612934832 no 1446 0.490326775923369 2293 442583
SGTC_3230 9131665 49.47 µM 0.0234268247884399 0.443923726676115 no 1447 0.49065490389405 2366 15943720
SGTC_271 rotenone 740 µM 0.0226321598928251 0.444246481469981 no 1448 0.490971845254063 2315 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3257 9139206 32.98 µM 0.0224114179281025 0.444336142847772 no 1449 0.491059886225285 2361 4910041
SGTC_3039 9090270 49.47 µM 0.022304108728623 0.444379730925367 no 1450 0.491102685703598 2372 17173750
SGTC_1661 st013063 9.66 µM 0.0222000235359596 0.444422010081699 no 1451 0.491144199408576 2369 721395
SGTC_399 oxolinic acid 75 µM 0.0205362166682355 0.445097929981502 no 1452 0.491807810719393 2354 4628 A DNA gyrase inhibitor.
SGTC_2931 9014674 55.67 µM 0.020414273047104 0.445147475760411 no 1453 0.49185644898914 2365 2996810
SGTC_1436 4092-1007 8.32 µM 0.0202342263145716 0.445220630440581 no 1454 0.491928262409398 2369 2881121
SGTC_1564 D-Arginine 115 µM 0.0201331180496184 0.445261712497306 no 1455 0.491968590555879 2341 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_120 rhodamine 6G 52.259 µM 0.0191622816344973 0.445656210173203 no 1456 0.492355823484634 2378 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_900 1112-0045 141 µM 0.0190168273051194 0.445715319929608 no 1457 0.492413840794401 2373 56211 YIL048W NEO1
SGTC_308 4092-1169 104 µM 0.0189589452158288 0.445738842399109 no 1458 0.492436928244746 2367 2268590 YDL196W YDL196W
SGTC_3062 9077494 49.47 µM 0.0184120111202831 0.445961118164413 no 1459 0.49265508528956 2339 16459633
SGTC_2459 5811157 9.22 µM 0.0175769329130886 0.446300529357872 no 1460 0.49298817935171 2366 2870684 YBR192W RIM2
SGTC_250 brefeldin a 552.239 µM 0.0166366943276765 0.446682729269055 no 1461 0.493363225381956 2363 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1097 itavastatin 7.23 µM 0.0165925441314539 0.446700677211929 no 1462 0.493380836331036 2373 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1695 st026914 34.495 µM 0.0159613349552219 0.44695728835997 no 1463 0.493632618999329 2371 3289191
SGTC_2517 totarol 10 µM 0.0154096609004647 0.447181583570998 no 1464 0.493852678029223 2348 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_184 1494-0393 24.714 µM 0.0144612275154072 0.447567229456502 no 1465 0.494231005993799 2361 3090647
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0136170776239172 0.447910513965943 no 1466 0.494567739880124 2385 88881 An O-methylated flavonoid and antioxidant.
SGTC_2762 leflunomide 42.06 µM 0.013007092679686 0.448158596558187 no 1467 0.494811067099854 2385 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2741 miltefosine 3.04 µM 0.0125127162853513 0.448359675709017 no 1468 0.495008278688807 2373 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0123749505304453 0.448415711941813 no 1469 0.495063235018056 2377 6708784 An antioxidant flavonoid
SGTC_2490 carminic acid 95.39 µM 0.0119282143125027 0.448597429011666 no 1470 0.495241443824371 2377 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0105063704102254 0.449175858262698 no 1471 0.495808641739633 2385 2374 Ca(2+)-ATPase inhibitor.
SGTC_2467 5474540 200 µM 0.0101983332043259 0.44930118709334 no 1472 0.49593152421961 2380 5413519
SGTC_2862 9027634 71.43 µM 0.00974406333603432 0.449486021757472 no 1473 0.496112742666199 2376 5012562
SGTC_880 0833-0487 87.2 µM 0.0093357089890429 0.449652183535131 no 1474 0.496275645066472 2387 76075
SGTC_3058 9093861 49.47 µM 0.00855763166992626 0.449968812170129 no 1475 0.496586040575931 2380 17217477
SGTC_2913 7966556 36.57 µM 0.00780701446734805 0.450274296449333 no 1476 0.496885483483326 2389 2976516
SGTC_2666 tannic acid 100 µM 0.00758797878352628 0.450363444596058 no 1477 0.49697286348961 2395 16134267 A thiamine antagonist.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.00694315642202615 0.450625903655069 no 1478 0.497230103598758 2394 688669
SGTC_944 3370-0224 231 µM 0.0068783023190226 0.450652302117137 no 1479 0.497255976024682 2383 4580514
SGTC_3102 9121669 49.47 µM 0.00651727338779766 0.450799260700672 no 1480 0.497400002498437 2380 41905072
SGTC_1789 tunicamycin 25 nM 0.00488439993601975 0.45146401373572 no 1481 0.498051414099155 2394 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3098 9119039 49.47 µM 0.0042778024594612 0.451710998155072 no 1482 0.498293408936704 2399 17161528
SGTC_3302 9125395 16.351 µM 0.00262960601716145 0.452382177891966 no 1483 0.498950940187968 2395 17599668
SGTC_3336 9143619 71.43 µM 0.00236611041443308 0.452489491427895 no 1484 0.499056059396356 2400 45595730
SGTC_64 000l-0018 272.079 µM 0.00220311918879144 0.452555874405473 no 1485 0.499121083317832 2396 6811119
SGTC_518 1021-0119 62.6 µM 0.00214624374236382 0.452579038918523 no 1486 0.499143773284473 2398 1097762
SGTC_3161 9100388 49.47 µM 0.0014547485814656 0.452860687373873 no 1487 0.499419639488202 2401 25236368
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.00104741211706734 0.453026608084253 no 1488 0.4995821430979 2401 5024745
SGTC_136 0097-0015 404.482 µM 0.000731327568816406 0.453155364726314 no 1489 0.499708242537983 2401 4861337
SGTC_1855 st056195 39.6 µM 0.000710836503527126 0.453163711906046 no 1490 0.499716417288172 2402 4028379
SGTC_1082 camptothecin 424.86 nM 4.97332107006454e-05 0.453433028071262 no 1491 0.49998015931952 2404 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2448 5185112 27.17 µM 0 0.453453288946387 no 1492 0.5 2406 5718189
SGTC_182 3448-4371 550.524 µM -9.10334425789112e-05 0.453490375488624 no 1493 0.499963682910875 2399 3491403
SGTC_2259 7964009 200 µM -0.000100510486604856 0.45349423640947 no 1494 0.499959902117337 2408 313134
SGTC_3271 9137798 49.47 µM -0.000388211925420901 0.453611447249844 no 1495 0.499845125853084 2408 6498326
SGTC_1319 1306-0155 43.7 µM -0.00208507297164244 0.454302837818838 no 1496 0.499168176836619 2409 3122360
SGTC_76 0433-0009 400.328 µM -0.00320148171386131 0.454757797206003 no 1497 0.49872279576619 2430 2841569
SGTC_2291 7917025 104.35 µM -0.00351839110819322 0.454886955105047 no 1498 0.498596367923899 2416 2964612
SGTC_349 k015-0014 24 µM -0.00388483182526186 0.455036305670103 no 1499 0.498450180230947 2413 2196908
SGTC_2670 beta-carotene 100 µM -0.00421441120474284 0.4551706380569 no 1500 0.498318698160439 2418 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2426 5582046 32.21 µM -0.00472591938605578 0.455379132468478 no 1501 0.498114637961181 2414 2251934
SGTC_145 3737-0113 38.366 µM -0.0062363710957116 0.455994874958532 no 1502 0.497512064020593 2423 6849351
SGTC_413 propylparaben 100 µM -0.00633217241536009 0.456033932381228 no 1503 0.497473845578352 2419 7175 A pharmaceutical preservative.
SGTC_81 0411-0046 9.971 µM -0.00660855760087442 0.456146614764152 no 1504 0.497363586150589 2416 12925265
SGTC_2983 9022671 12.99 µM -0.00740058727176842 0.456469545175502 no 1505 0.497047619787183 2422 6405161
SGTC_62 0180-0423 3.232 µM -0.00750833921344369 0.456513480578085 no 1506 0.497004634176225 2432 30102 YGL099W LSG1
SGTC_755 1995-0008 37.3 µM -0.00794297093625172 0.456690705233082 no 1507 0.496831246381425 2413 689533
SGTC_1630 st005209 31.3 µM -0.00825414094478387 0.456817592653817 no 1508 0.496707111579986 2414 3367314
SGTC_337 1315-0038 354 µM -0.00837250551062422 0.456865859948116 no 1509 0.496659892581911 2427 1626437
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.00863093598881563 0.456971246230791 no 1510 0.496556797463789 2418 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_88 0180-0332 8.668 µM -0.00948915014866404 0.457321242102348 no 1511 0.496214433611944 2420 3101745
SGTC_353 1988-1175 58.3 µM -0.00971093375689497 0.457411695021741 no 1512 0.496125958830749 2374 2788357
SGTC_999 SEC7.066 22.7 µM -0.0107402905256956 0.457831539908588 no 1513 0.495715326381256 2436 740511 YDR170C SEC7
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0110897736116349 0.457974094686565 no 1514 0.49557591110777 2427 1241132 A phosphatase inhibitor.
SGTC_3176 9106582 49.47 µM -0.0112582231970731 0.458042807506818 no 1515 0.495508713641312 2419 17018027
SGTC_3212 9128307 49.47 µM -0.0130417380150959 0.458770403382402 no 1516 0.494797246782998 2449 27243542
SGTC_1191 1487-1166 10.6 µM -0.0136698537970024 0.459026680110426 no 1517 0.494546687192793 2468 3955771
SGTC_1962 st076595 64.5 µM -0.0139112445854434 0.459125174197136 no 1518 0.494450395358208 2425 279619
SGTC_2255 7941087 197.44 µM -0.0165625211913842 0.460207131841593 no 1519 0.493392812105539 2436 935561
SGTC_1470 k295-0292 231 µM -0.0170372609580682 0.46040089940753 no 1520 0.493203445067215 2494 5045612
SGTC_129 0088-0017 176.636 µM -0.0181968833952865 0.460874244932881 no 1521 0.492740894458077 2426 182446
SGTC_2922 7999257 32.47 µM -0.018554802618944 0.461020354975171 no 1522 0.492598129453433 2442 2988377
SGTC_3233 9132340 49.47 µM -0.018761026492149 0.461104542223343 no 1523 0.492515872350155 2444 17682950
SGTC_526 4469-0568 170 µM -0.0192754135698549 0.461314539236943 no 1524 0.492310698706886 2433 2901964
SGTC_2267 7931562 200 µM -0.0209176096021276 0.461985032850786 no 1525 0.491655689633032 2438 934880
SGTC_2593 nobiletin 86.24 µM -0.0209563958870996 0.462000870249643 no 1526 0.491640219535151 2461 72344 An anti-infammatory.
SGTC_1206 3978-0017 132 µM -0.0210872109907608 0.462054285734037 no 1527 0.491588043389439 2532 3873677
SGTC_3219 9131112 49.47 µM -0.0210907305418123 0.462055722875134 no 1528 0.491586639603914 2451 17612988 YMR079W SEC14
SGTC_273 hydroxyurea 18.1 mM -0.0226012739795679 0.462672569772551 no 1529 0.490984163799761 2437 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_18 0111-0177 500 nM -0.0232595529595524 0.462941413351636 no 1530 0.490721617520083 2445 721752
SGTC_2746 daunorubicin 9.88 µM -0.0237596002920882 0.463145645858442 no 1531 0.490522182620479 2437 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_482 fipronil 114 µM -0.0251508635631986 0.463713925384298 no 1532 0.489967314869662 2447 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_11 0438-0307 1.3 µM -0.0252215306382376 0.463742792253338 no 1533 0.489939131725931 2456 4011476
SGTC_1529 apigenin 74 µM -0.0259469277929671 0.46403912152224 no 1534 0.489649834832706 2471 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1826 st055655 41.6 µM -0.0275473178171593 0.464692961171851 no 1535 0.489011599995186 2485 676168
SGTC_1444 4112-3581 28 µM -0.0277176732684972 0.464762565569813 no 1536 0.488943663944433 2454 2877249
SGTC_2367 9070478 135.38 µM -0.0289933576486393 0.465283823068684 no 1537 0.488434944098689 2464 572802
SGTC_1571 st070080 73.4 µM -0.0292016531908846 0.465368940408708 no 1538 0.488351881370807 2478 4315245
SGTC_428 3448-4153 16.5 µM -0.0304791734789589 0.465891017438008 no 1539 0.487842451409971 2449 3834874
SGTC_1505 k297-0037 20.6 µM -0.0311625769179587 0.466170324236181 no 1540 0.487569942351393 2464 4089396
SGTC_377 3970-0964 33.1 µM -0.0314834590798658 0.466301474444868 no 1541 0.487441991674146 2470 16481235
SGTC_2369 9071472 200 µM -0.0320103210828421 0.466516820184045 no 1542 0.487231910041295 2519 17296037
SGTC_2123 5259487 200 µM -0.0327209749293924 0.466807303180123 no 1543 0.48694854863553 2473 2173474
SGTC_332 4112-0506 40.9 µM -0.0334182053805947 0.46709231648605 no 1544 0.486670545988098 2464 2790355
SGTC_1043 0916-0009 19.3 µM -0.0363064836081051 0.468273162652764 no 1545 0.485518990089046 2461 3101130
SGTC_1382 3002-2117 298 µM -0.0364833776758618 0.468345493355393 no 1546 0.485448466289423 2462 1497314
SGTC_3110 9122132 49.47 µM -0.03660068562314 0.468393460301483 no 1547 0.485401698424914 2584 918317
SGTC_2947 9072639 7.68 µM -0.0366366345484308 0.468408159825088 no 1548 0.485387366490936 2495 16488146
SGTC_2011 4012611 177 µM -0.0369591907721639 0.46854005506186 no 1549 0.485258772269361 2478 2049887
SGTC_2693 st077581 40.7 µM -0.0374026766382692 0.468721404812823 no 1550 0.485081969258476 2467 25238761
SGTC_2753 fluvastatin 17.09 µM -0.0378279295575333 0.468895304863232 no 1551 0.484912437868745 2523 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2228 7354201 200 µM -0.0395113411427556 0.469583765727308 no 1552 0.484241355827025 2494 753451
SGTC_1912 st060209 90.8 µM -0.0400037994162726 0.469785182511012 no 1553 0.484045048611606 2506 688787
SGTC_2431 5490079 200 µM -0.040932944549609 0.470165226431479 no 1554 0.483674676747791 2500 5722345
SGTC_1791 st048313 56.1 µM -0.0411502619202646 0.470254118681201 no 1555 0.483588052646661 2486 1204976
SGTC_1236 0330-0013 258 µM -0.0413076731504093 0.470318507641783 no 1556 0.483525308001824 2510 4617066
SGTC_374 0880-0231 82.3 µM -0.0413373787547108 0.470330658786861 no 1557 0.483513467293927 2505 6833587
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0418319080853803 0.470532951185212 no 1558 0.483316349147223 2533 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2789 5281112 71.43 µM -0.0418742353831383 0.470550265963382 no 1559 0.48329947778162 2510 765948
SGTC_198 3454-2873 16.191 µM -0.0420175545591913 0.470608893784274 no 1560 0.483242351980089 2497 710957
SGTC_1943 st076331 65.2 µM -0.0420580855804881 0.470625473994208 no 1561 0.483226196722945 2480 24208415
SGTC_3151 9099821 49.47 µM -0.0421732043637546 0.470672566438092 no 1562 0.483180311684885 2535 17174189
SGTC_795 0685-0265 78 µM -0.0427607073224037 0.470912906746149 no 1563 0.482946143168122 2474 302754
SGTC_2943 9068529 45.32 µM -0.0429818415721926 0.471003372824764 no 1564 0.4828580044008 2475 3270634
SGTC_1085 doxorubicin 7.67 µM -0.0432611997404329 0.471117660462065 no 1565 0.482746660184979 2482 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1832 st054113 55 µM -0.0460710493611337 0.472267322889153 no 1566 0.481626810380366 2487 1251267
SGTC_276 colchicine 750 µM -0.0465821407905304 0.472476463333633 no 1567 0.481423133080918 2573 2833 A microtubule depolymerizer.
SGTC_3169 9102970 49.47 µM -0.0476745931120459 0.472923524111049 no 1568 0.4809877914157 2497 17027839
SGTC_655 k060-0012 42 µM -0.0477852230085739 0.472968798741938 no 1569 0.48094370671678 2487 5994525
SGTC_2103 5378138 10 µM -0.0481355608125526 0.473112174717484 no 1570 0.480804102805829 2480 244142
SGTC_803 4488-1585 147 µM -0.0484082239323784 0.473223764689267 no 1571 0.480695452620137 2483 747204
SGTC_1112 tnp00069 1.16933 µM -0.048619820384682 0.473310363995848 no 1572 0.480611137130398 2600 145826
SGTC_1184 1269-1718 139 µM -0.0491345604364471 0.473521035033806 no 1573 0.480406030706522 2539 5403821
SGTC_922 1866-0035 480 µM -0.0492003240869674 0.473547951089272 no 1574 0.480379826498487 2501 3156169
SGTC_486 niguldipine 82 µM -0.0502270220304543 0.473968178423514 no 1575 0.479970739129388 2488 1236 A calcium channel blocker.
SGTC_2606 farnesol 9.78 µM -0.0510003681576877 0.474284728045304 no 1576 0.479662613592088 2517 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2212 7123476 200 µM -0.0513199272723908 0.474415536215538 no 1577 0.47953529467952 2499 1085715
SGTC_1254 0550-0035 264 µM -0.0521358166024622 0.474749524429091 no 1578 0.479210237119755 2546 15121435
SGTC_1807 st050092 58.9 µM -0.0521652737405654 0.474761583183292 no 1579 0.479198501391471 2503 5008496
SGTC_820 1582-0060 59.9 µM -0.0529865688396368 0.475097802836901 no 1580 0.478871304596793 2521 3848840
SGTC_1925 st057770 10.1 µM -0.0549072081768697 0.475884137991585 no 1581 0.478106194624683 2507 5989122
SGTC_263 alizarin 107.927 µM -0.0560488193787358 0.476351573425754 no 1582 0.477651458008326 2486 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_52 0329-0193 875 nM -0.0567886699851003 0.476654524444302 no 1583 0.477356769707841 2676 3739292
SGTC_3315 9136395 68.55 µM -0.0569898729312837 0.476736914549913 no 1584 0.477276631130596 2510 16876844
SGTC_2534 helenine 20.12 µM -0.0574418386830553 0.476921992528173 no 1585 0.477096617776461 2518 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2585 alliin 100 µM -0.0575625596299766 0.476971428066576 no 1586 0.477048536642582 2558 87310 A garlic compound which reacts with lipids.
SGTC_1862 st057513 3.81 µM -0.0586496631674262 0.477416615636415 no 1587 0.47661557662272 2524 5393163
SGTC_2438 5259590 200 µM -0.0598549671252556 0.477910241232934 no 1588 0.476135573288903 2575 1201127
SGTC_3094 9117742 49.47 µM -0.0598589514471883 0.477911873046652 no 1589 0.476133986619377 2504 17149698
SGTC_873 0591-4978 488 µM -0.0612806501868849 0.478494165570511 no 1590 0.47556785037501 2524 3305145
SGTC_2061 5245884 80.95 µM -0.0616547711667253 0.478647403920568 no 1591 0.475418879392031 2539 573863
SGTC_1760 st045453 10.4495 µM -0.0619273040487694 0.478759034209607 no 1592 0.475310361867926 2501 3323419 YIL048W NEO1
SGTC_2263 7948595 193.29 µM -0.0634635704787185 0.479388324481934 no 1593 0.474698683644467 2514 2971371
SGTC_2049 5262831 67.185 µM -0.0636796244913056 0.479476829361171 no 1594 0.474612664556429 2540 763417
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0643440122869769 0.479748997078166 no 1595 0.474348154650889 2590 6708739 YPR165W RHO1
SGTC_2350 9023895 38.85 µM -0.0643802089704469 0.47976382539037 no 1596 0.474333744142007 2586 2997209
SGTC_470 aa-861 153 µM -0.0657877577637018 0.480340462524287 no 1597 0.473773401505139 2531 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2659 sanguinarine 24.21 µM -0.0661432479630384 0.480486104421295 no 1598 0.47363188966097 2525 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_825 1988-2224 89.6 µM -0.0663436389161151 0.480568204369979 no 1599 0.473552120450835 2521 1180859
SGTC_2856 9022925 19.48 µM -0.0670018905292632 0.480837895099652 no 1600 0.47329009907985 2614 4944862
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0670365780412991 0.480852107083473 no 1601 0.473276291807761 2504 97141
SGTC_633 0437-0093 97.7 µM -0.0674949439212723 0.481039908604309 no 1602 0.473093843507519 2508 2831118
SGTC_2320 7373003 200 µM -0.069352942818514 0.481801209980978 no 1603 0.472354342435747 2563 5415828
SGTC_2056 5235370 200 µM -0.0697495687514564 0.481963733229002 no 1604 0.472196493831327 2578 5511916
SGTC_2782 7736369 71.43 µM -0.0697499158723279 0.481963875468148 no 1605 0.472196355686583 2547 2950836 YOL077C BRX1
SGTC_1056 3448-1962 115 µM -0.0701461281047603 0.482126232191787 no 1606 0.472038676089813 2597 715507
SGTC_2323 6148992 148.28 µM -0.0710129963375795 0.48248146091973 no 1607 0.471693706011767 2581 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2389 9091542 195.52 µM -0.0714554033430586 0.48266275760802 no 1608 0.471517658380905 2592 3626624 YOL127W RPL25
SGTC_2317 5986382 200 µM -0.0715522408210172 0.482702441713364 no 1609 0.471479124450729 2562 877883
SGTC_3171 9103192 49.47 µM -0.0717614947673267 0.482788194796255 no 1610 0.47139585825276 2537 13018434
SGTC_2594 a-mangostin 100 µM -0.0722438376407478 0.482985863812498 no 1611 0.471203929450445 2620 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1859 st055998 20 µM -0.0723276259378284 0.4830202015367 no 1612 0.471170589973197 2534 676301
SGTC_1313 1220-0047 237 µM -0.0731550382473197 0.483359294464058 no 1613 0.470841372376937 2574 3528706
SGTC_1472 k841-0093 193 µM -0.07352514171618 0.483510975437471 no 1614 0.470694119009835 2632 X1472
SGTC_2885 9057732 51.95 µM -0.0748763407341538 0.484064762788768 no 1615 0.47015655053074 2618 6471414
SGTC_1833 st055984 71 µM -0.0751872547534375 0.48419219492848 no 1616 0.470032862441649 2578 676288
SGTC_2879 9041815 71.43 µM -0.0753177412264831 0.4842456769821 no 1617 0.469980953058669 2533 4942971
SGTC_1881 5652484 16 µM -0.0757963495214056 0.484441844979794 no 1618 0.469790560215983 2534 2255129
SGTC_534 k292-0788 63.4 µM -0.0761206079940169 0.484574751495475 no 1619 0.469661572449046 2526 4146317
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0765211732575135 0.484738936874382 no 1620 0.469502234768175 2547 5106787 A p450 inhibitor.
SGTC_2221 6807166 181.081 µM -0.0766893097833692 0.484807854154998 no 1621 0.469435354526161 2553 674925
SGTC_2286 7945697 125 µM -0.0769348438864182 0.484908496651162 no 1622 0.46933768913437 2594 1245733
SGTC_1660 st012960 28.1 µM -0.0778696920650749 0.48529169230466 no 1623 0.468965854205798 2598 24207266
SGTC_2756 carbadox 75.1 µM -0.0779266742411083 0.485315049825814 no 1624 0.468943190474174 2577 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2971 9092186 9.93 µM -0.0786910124458544 0.485628363966227 no 1625 0.468639197170823 2554 25236400
SGTC_702 1488-0190 94 µM -0.0788126440378848 0.485678223474391 no 1626 0.468590823422351 2574 949357
SGTC_2656 pseudo-anisatin 100 µM -0.0799601465356425 0.486148621308436 no 1627 0.468134476447001 2548 6708809 A neurotoxin.
SGTC_2917 7979103 53.79 µM -0.0803652031246971 0.486314671545888 no 1628 0.467973400622107 2618 2980565
SGTC_2010 4012422 159 µM -0.0818669225046525 0.486930311833054 no 1629 0.467376269066915 2611 952393
SGTC_3127 9126946 49.47 µM -0.081906738375317 0.486946635056045 no 1630 0.467360437998994 2642 27243249
SGTC_2898 9056270 58.44 µM -0.0821728225367719 0.487055721541645 no 1631 0.467254642406865 2537 19154699
SGTC_861 0443-0273 110 µM -0.0822504482544101 0.48708754592885 no 1632 0.46722377870257 2628 6149169
SGTC_2681 menadione 3.18 µM -0.0823297719061217 0.487120066506787 no 1633 0.467192240109406 2581 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1363 1636-0063 10.4 µM -0.0830968729777248 0.487434561838471 no 1634 0.466887256125481 2561 6072185
SGTC_751 0833-0568 350 µM -0.0845255513717447 0.488020310659867 no 1635 0.466319294237051 2613 6954252
SGTC_752 1896-0090 130 µM -0.085603175320317 0.488462146614623 no 1636 0.465890937093727 2563 772567
SGTC_628 1636-0253 16 µM -0.086247237986841 0.488726225161326 no 1637 0.465634940046868 2610 4456143
SGTC_2418 pentamidine 31.67 µM -0.0872467234369141 0.48913604388674 no 1638 0.465237700495452 2541 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_843 0310-0051 143 µM -0.087561634641748 0.489265169232331 no 1639 0.465112548066363 2573 2065037
SGTC_3005 9076496 71.4286 µM -0.0876447817767527 0.489299262848815 no 1640 0.465079504196951 2567 21368410
SGTC_197 4544-0043 41.561 µM -0.0877780743193743 0.489353918230317 no 1641 0.465026532322601 2568 896523
SGTC_2355 9061122 103.12 µM -0.0881224987408386 0.489495147220603 no 1642 0.464889657265786 2628 5302957
SGTC_1914 st062367 72.6 µM -0.0887243554792873 0.489741937806532 no 1643 0.464650487996347 2598 978205
SGTC_2786 7743617 45.45 µM -0.0887863090906541 0.489767342030192 no 1644 0.464625869239807 2603 583674
SGTC_2619 obliquin 87.91 µM -0.0890702938774579 0.489883791187816 no 1645 0.464513022793631 2574 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2028 5153890 36.43 µM -0.089410503959517 0.49002329689894 no 1646 0.464377837977198 2563 2830968 YPR165W RHO1
SGTC_683 panaxydol 45 µM -0.0895720969506816 0.490089559752806 no 1647 0.464313629330016 2637 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_55 0767-0285 6.563 µM -0.0900582086529111 0.490288896455075 no 1648 0.464120479441165 2572 3116166
SGTC_2887 9044784 58.44 µM -0.0904591790060643 0.490453321619049 no 1649 0.463961165673925 2584 6465546
SGTC_1946 st076057 65.1 µM -0.0936648737705368 0.491767930875982 no 1650 0.462687687118827 2577 953009
SGTC_804 1595-0054 20.9 µM -0.0936906631071146 0.491778507093235 no 1651 0.46267744370649 2581 761523 Stimulates phospholipase C.
SGTC_753 1322-0200 289 µM -0.0941837558168107 0.491980725713932 no 1652 0.462481594195044 2695 5403907
SGTC_398 bronopol 33.3 µM -0.0945091477876827 0.49211417095136 no 1653 0.462352358044423 2577 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_4 0960-0234 25.671 µM -0.0956958227746763 0.492600840988275 no 1654 0.461881079308984 2616 6821112
SGTC_1993 st073995 70.8 µM -0.0966338295818192 0.492985536969575 no 1655 0.461508595042374 2622 3098394
SGTC_1124 fisetin 1.16336 µM -0.0967513455948256 0.493033733182918 no 1656 0.461461931585832 2660 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_278 4092-0821 23.9 µM -0.0973716434154436 0.493288134276035 no 1657 0.461215631487935 2661 877900
SGTC_2981 9013952 38.96 µM -0.0979855709127607 0.493539925413768 no 1658 0.460971875485556 2646 2996344
SGTC_1343 1487-0095 224 µM -0.0981808722381922 0.493620025225832 no 1659 0.460894335408147 2575 4560101 YGL055W OLE1
SGTC_133 0724-0033 378.92 µM -0.0992013669543355 0.494038569428975 no 1660 0.460489194770691 2558 280309
SGTC_2250 alverine citrate 130 µM -0.0999020462023287 0.494325948813825 no 1661 0.460211045922867 2550 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2566 crystal violet carbinol 226 nM -0.100511398300422 0.494575873316006 no 1662 0.459969167064317 2740 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1231 0242-0792 125 µM -0.100679394748269 0.49464477709004 no 1663 0.459902484428654 2579 3707635
SGTC_769 0302-0231 76 µM -0.100714706649322 0.494659260293152 no 1664 0.459888468260013 2632 571869 YER009W NTF2
SGTC_2558 carylophyllene oxide 100 µM -0.102619159498073 0.495440383008877 no 1665 0.459132618019198 2568 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2413 inermin 26.06 µM -0.10432803503644 0.496141303490699 no 1666 0.458454515281459 2835 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2956 9076196 2.52 µM -0.104438813222367 0.496186741230354 no 1667 0.458410561291956 2633 16423868
SGTC_94 0334-0113 514.748 µM -0.105704836830756 0.496706027800242 no 1668 0.45790827130956 2600 6795178
SGTC_439 amiodarone 34.4 µM -0.105826377474815 0.496755880593774 no 1669 0.457860054051394 2674 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1241 0364-0022 50.8 µM -0.106236322222789 0.496924029577149 no 1670 0.457697426516207 2673 4563895
SGTC_935 2996-0153 430 µM -0.109431883249527 0.498234784426861 no 1671 0.456429973209341 2608 23738523
SGTC_3190 9110366 49.47 µM -0.109569975918227 0.498291427792881 no 1672 0.456375211500204 2625 17123768
SGTC_2968 9090663 33.37 µM -0.109614745416294 0.498309791520065 no 1673 0.45635745798946 2711 25236811
SGTC_1477 0139-0234 16 µM -0.110046245789513 0.498486786202576 no 1674 0.456186349385513 2589 620880
SGTC_452 diindolylmethane 8 µM -0.111685459410104 0.499159168327901 no 1675 0.455536404450616 2690 3071 Inhibits expression of several cancer promoting factors.
SGTC_3299 9121982 43.1275 µM -0.11245543199946 0.499475001079692 no 1676 0.455231152816612 2634 17594604 YPL160W CDC60
SGTC_163 TUB2.036 7.546 µM -0.11335834602638 0.499845365086497 no 1677 0.45487323092202 2615 15992207 YJR013W GPI14
SGTC_3083 9117465 49.47 µM -0.113657863695739 0.499968223522169 no 1678 0.454754507947957 2698 16420915
SGTC_522 1273-0010 11.6 µM -0.113812800005012 0.499968223522169 no 1679 0.454693095796164 2848 5705015
SGTC_1484 3473-2379 286 µM -0.114694546665482 0.499606542023091 no 1680 0.454343618266917 2597 671917
SGTC_1743 st037606 46.3785 µM -0.115809367914494 0.499149256730855 no 1681 0.453901812976711 2645 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2975 9084847 53.72 µM -0.116691491488538 0.498787421785008 no 1682 0.453552266509431 2724 27211724
SGTC_919 tnp00227 403.569 nM -0.116801832140786 0.498742161632601 no 1683 0.453508545926615 2663 1269246 A methoxyflavone. YNL221C POP1
SGTC_1782 st039423 80.636 µM -0.118835198739412 0.497908107332121 no 1684 0.452702960849768 2662 2068169
SGTC_682 0kpi-0099 17 µM -0.119785945276328 0.497518129297277 no 1685 0.452326357907956 2710 1714895 YML126C ERG13
SGTC_2229 7354935 190 µM -0.119823752372118 0.497502621596669 no 1686 0.452311382915051 2615 318112
SGTC_275 trichlorophene 5.69 µM -0.121308308643683 0.496893690072372 no 1687 0.451723419637971 2705 62616
SGTC_794 k038-0031 316 µM -0.122064236767894 0.496583628084251 no 1688 0.451424072478984 2610 6624242
SGTC_162 k030-0015 37.8 µM -0.123532951142901 0.495981205847057 no 1689 0.450842541436955 2688 1809920 YMR134W ERG29
SGTC_3184 9108758 49.47 µM -0.123857367436626 0.49584814127811 no 1690 0.45071410440449 2599 902885
SGTC_957 1187-1561 14.1 µM -0.124744354276001 0.495484331739024 no 1691 0.450362970997734 2609 1538454
SGTC_2875 9039966 71.43 µM -0.124749815189818 0.49548209188336 no 1692 0.450360809293969 2730 6463691
SGTC_671 0560-0003 407 µM -0.124991409490393 0.495382999387702 no 1693 0.450265175619166 2716 3238678
SGTC_3009 9080819 71.4286 µM -0.125302818006263 0.495255272263377 no 1694 0.45014191066114 2694 17027216
SGTC_2239 6685329 187.64 µM -0.125439425543734 0.495199241552988 no 1695 0.450087838761719 2776 805680
SGTC_1081 sertraline 6 µM -0.125674118414958 0.495102980554142 no 1696 0.449994944958349 2704 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_279 1273-0055 2.93 µM -0.125955802919973 0.49498744596975 no 1697 0.449883455010894 2674 2847562
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.12689572494719 0.494601934425649 no 1698 0.449511465143493 2629 17037758
SGTC_717 1532-0246 73.2 µM -0.127776298473698 0.494240769395498 no 1699 0.449163003683815 2697 9561992
SGTC_605 1315-0399 119 µM -0.127987255601124 0.49415424654695 no 1700 0.449079529324068 2729 24020461
SGTC_716 1683-5115 658 µM -0.128219378064801 0.494059043175801 no 1701 0.448987682583206 2621 723597
SGTC_1930 st074634 34.3 µM -0.128571625081725 0.493914572224959 no 1702 0.448848309910861 2635 684253 YOR116C RPO31
SGTC_1128 3448-9350 235 µM -0.128899218830675 0.49378021330653 no 1703 0.448718697398091 2747 619386
SGTC_3253 9135987 49.47 µM -0.129064414357416 0.493712460472367 no 1704 0.448653339839666 2753 4182430
SGTC_1672 st016598 6.51 µM -0.129361589957411 0.493590578155749 no 1705 0.448535769513739 2697 4665860 YNL267W PIK1
SGTC_3142 9086498 49.47 µM -0.129620341804488 0.493484455278043 no 1706 0.448433404295226 2705 25236367
SGTC_2648 atorvastatin 78.68 µM -0.130877375689221 0.492968909896095 no 1707 0.44793615615156 2676 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1605 st000082 49.1 µM -0.131560989549506 0.49268854526564 no 1708 0.447665771538772 2766 1114022
SGTC_1794 st048918 76.9 µM -0.131822927290994 0.492581119958406 no 1709 0.44756217572456 2597 672303
SGTC_1681 tripelennamine 100 µM -0.13216513034992 0.492440777234661 no 1710 0.4474268405399 2626 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1644 st010134 20.9 µM -0.132925697914094 0.492128860186003 no 1711 0.447126071623817 2661 3818134
SGTC_788 1182-0090 188 µM -0.133218480311663 0.492008788205819 no 1712 0.447010297968749 2851 5715185
SGTC_2199 6590217 200 µM -0.133446154724656 0.491915417936738 no 1713 0.446920272797983 2670 703109
SGTC_1245 0418-0076 17.2 µM -0.13409980523027 0.491647355494665 no 1714 0.44666182682819 2818 6790114
SGTC_2466 5983409 37.09 µM -0.134776763674531 0.491369738431666 no 1715 0.446394189045094 2693 2879657
SGTC_191 3914-0123 66.505 µM -0.13494711452918 0.491299879103893 no 1716 0.446326844106084 2647 3144412
SGTC_608 k048-0125 159 µM -0.135431764491426 0.491101130052934 no 1717 0.446135255524642 2695 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_379 3970-0972 5.9 µM -0.135487048004731 0.491078459096427 no 1718 0.446113402014115 2697 2898042 YBL034C STU1
SGTC_932 2857-0803 154 µM -0.135986034388024 0.490873833425322 no 1719 0.445916160673207 2879 674898
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.136793546461528 0.490542691825667 no 1720 0.445596992434011 2702 16725076
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.137241299123433 0.490359081845149 no 1721 0.445420033878143 2627 756377
SGTC_1175 0741-0056 27.6 µM -0.137957635990862 0.490065337776448 no 1722 0.445136949451466 2800 765927
SGTC_1282 0886-0010 32.4 µM -0.139213531159732 0.489550353292331 no 1723 0.444640708151834 2734 2836211 YNL267W PIK1
SGTC_492 tmb-8 126 µM -0.139530608337249 0.489420337337062 no 1724 0.444515435273802 2637 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1626 st003712 1.76 µM -0.139992150315065 0.48923108630564 no 1725 0.444333096227496 2792 24207035
SGTC_479 n-linoleoylglycine 10 µM -0.144634585877676 0.487327640414754 no 1726 0.442499694380678 2675 6433346 An anti-infammatory.
SGTC_1285 0929-0069 65.5 µM -0.145119662628087 0.487128769912434 no 1727 0.44230819704544 2701 1206237
SGTC_1315 1237-0019 3.69 µM -0.145156376669311 0.487113718115138 no 1728 0.442293703720117 2741 825140
SGTC_3087 9117406 49.47 µM -0.146175840484507 0.486695772004919 no 1729 0.441891288591718 2793 42546093
SGTC_2007 4011539 71.82 µM -0.14682081093176 0.486431363183608 no 1730 0.441636728972779 2666 45595301
SGTC_802 4112-3352 742 µM -0.147031428379846 0.486345020806508 no 1731 0.441553606818151 2814 704594
SGTC_3026 9090633 49.47 µM -0.148138829272304 0.485891053727997 no 1732 0.441116603083147 2667 25236842
SGTC_616 4092-0450 108 µM -0.148440365524644 0.485767445328733 no 1733 0.44099762291683 2724 787165
SGTC_235 0330-0087 5 mM -0.148613620550552 0.485696423718717 no 1734 0.440929262361696 2676 46494818 YHR062C RPP1
SGTC_1682 st012968 530 nM -0.149896691621727 0.485170474758711 no 1735 0.440423060965385 2688 24207270
SGTC_1955 wogonin 32.4 µM -0.150032863622908 0.485114657429739 no 1736 0.440369343641737 2929 5281703 A flavanone.
SGTC_898 1000-0849 28.3 µM -0.150292314445269 0.485008308534747 no 1737 0.440266998152631 2642 6751807
SGTC_2404 5161160 200 µM -0.150775428266058 0.484810283021462 no 1738 0.440076435025864 2649 2831543
SGTC_507 nimesulide 162 µM -0.151154658621429 0.484654841351571 no 1739 0.43992685821334 2878 4495 A COX2 inhibitor.
SGTC_2853 9015042 58.44 µM -0.151500008888631 0.48451328872437 no 1740 0.439790651913059 2648 6457456
SGTC_2496 diffractaic acid 79.83 µM -0.152906117232458 0.48393697150314 no 1741 0.439236155893839 2916 94870 An apoptosis inducer which activates caspases.
SGTC_1527 coumarin 137 µM -0.153212419668201 0.48381143269301 no 1742 0.439115381914545 2903 323 A hepatotoxic, DNA x-linker.
SGTC_1621 st003705 32.4 µM -0.155046545155591 0.483059745837352 no 1743 0.438392311612112 2842 24207032
SGTC_1174 0739-0097 51.1 µM -0.155270470221471 0.482967977818335 no 1744 0.438304047300662 2739 728447
SGTC_1005 4092-0690 4.4 µM -0.155385118162469 0.48292099363525 no 1745 0.438258857827974 2730 1529343
SGTC_1815 st051655 58.2 µM -0.155399229082714 0.482915210817202 no 1746 0.438253295942938 2697 5984156
SGTC_2084 5306078 60.6385 µM -0.156363845205271 0.482519908577582 no 1747 0.43787311696976 2756 679340
SGTC_2930 9013230 14.89 µM -0.160153890969432 0.48096690785946 no 1748 0.436379925071031 2794 2995857
SGTC_2518 prenyletin 46.28 µM -0.160236476298843 0.480933071008415 no 1749 0.43634739833908 2742 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_517 1365-0151 113 µM -0.160338563755088 0.480891243938241 no 1750 0.436307191171332 2853 768657
SGTC_2167 5876490 200 µM -0.161998472180456 0.48021117939645 no 1751 0.435653528501014 2937 686534
SGTC_707 0865-0008 204 µM -0.16291071061239 0.479837459675122 no 1752 0.43529436882114 2714 723043
SGTC_2533 agelasine 13.65 µM -0.163099236966315 0.479760227662122 no 1753 0.435220150282909 2809 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2347 9049783 174.81 µM -0.163233274967001 0.479705317898587 no 1754 0.435167383958103 2829 6467988 YPL169C MEX67
SGTC_781 4335-2806 94.4 µM -0.163954744699461 0.479409768562025 no 1755 0.434883385056051 2871 845254
SGTC_2524 avocatin b 10.57 µM -0.164722449641357 0.47909529145479 no 1756 0.43458122304779 2802 6710748
SGTC_3149 9097855 49.47 µM -0.16507179745961 0.478952191434294 no 1757 0.434443735414825 2828 25236625 YMR079W SEC14
SGTC_2483 5729050 27.16 µM -0.165248938868122 0.478879631721251 no 1758 0.43437402352955 2777 2865180
SGTC_3242 9133940 49.47 µM -0.165853132127026 0.478632150601033 no 1759 0.434136265852543 2862 17248444
SGTC_1889 st059080 5.18 µM -0.166044903229042 0.478553601745148 no 1760 0.434060806479134 2696 176925 Isolated from Daphnopsis sellowiana.
SGTC_2455 5377712 9.75 µM -0.166496452059456 0.478368652022881 no 1761 0.433883137525447 2774 2243908
SGTC_2844 9010103 25.97 µM -0.167190156447631 0.478084526982101 no 1762 0.433610214712339 2883 2480525
SGTC_2774 tamoxifen 10.92 µM -0.167596064288794 0.477918281810368 no 1763 0.433450533824119 2694 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_624 k048-0052 28 µM -0.168205583481191 0.477668652018736 no 1764 0.433210774274245 2757 6835531
SGTC_1271 0832-2808 169 µM -0.169691560857658 0.477060103957053 no 1765 0.432626355638465 2844 3663794
SGTC_2963 9082507 9 µM -0.170521811130629 0.47672011714106 no 1766 0.432299891376206 2854 16459611
SGTC_1767 st044992 70.3 µM -0.171023402237796 0.4765147241833 no 1767 0.432102682179948 2752 9600693
SGTC_2521 angolensin 13.4 µM -0.171301376670665 0.476400901102884 no 1768 0.431993399018712 2848 821428 A flavenoid.
SGTC_3010 9080089 71.4286 µM -0.174063791668944 0.475269872340749 no 1769 0.430907664409145 2820 17027233
SGTC_1235 benzylparaben 21.5 µM -0.174279895508821 0.475181400199241 no 1770 0.43082274925413 2802 7180
SGTC_2089 5281248 129.67 µM -0.174340988521259 0.475156389159469 no 1771 0.43079874413995 2721 2737878
SGTC_1160 4092-0570 10.5 µM -0.174887676054659 0.474932583585573 no 1772 0.430583947058666 2703 4994975
SGTC_2356 9061756 188.97 µM -0.175924622122175 0.474508095401128 no 1773 0.430176580684195 2785 20104043
SGTC_1868 st057644 42.7 µM -0.175977569329022 0.47448642150368 no 1774 0.430155782256494 2706 688665
SGTC_2090 5301565 104.445 µM -0.176553135836771 0.474250818692296 no 1775 0.429929703933127 2750 2056344
SGTC_3308 9128332 17.569 µM -0.177826971584361 0.473729417982236 no 1776 0.429429432336089 2866 17332805 YDL196W YDL196W
SGTC_454 lyso-paf C-16 6.67 µM -0.178296940872293 0.473537063586817 no 1777 0.429244890576796 2787 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_126 0417-1624 672.48 µM -0.178479608861254 0.4734623008096 no 1778 0.42917316692863 2740 41912 YDL195W SEC31
SGTC_1287 0971-0001 34.6 µM -0.179029705022816 0.473237161836283 no 1779 0.428957188627901 2719 4665869
SGTC_288 1315-0019 35.1 µM -0.179521823216307 0.47303575886629 no 1780 0.428763991612091 2775 6811474
SGTC_2023 5144124 124 µM -0.179614085251879 0.472998000719179 no 1781 0.42872777304528 2761 2830192
SGTC_894 0960-0238 55.9 µM -0.181159708171327 0.472365492404295 no 1782 0.428121109742557 2709 6741907 YDL195W SEC31
SGTC_2063 5246145 200 µM -0.182262766622645 0.471914135271963 no 1783 0.427688258576415 2842 711240
SGTC_3175 9106517 49.47 µM -0.182578273543623 0.471785040562905 no 1784 0.427564466487262 2820 41468073
SGTC_323 4013-0906 34.3 µM -0.182594594391423 0.471778362707194 no 1785 0.427558063043967 2840 2910086
SGTC_1393 3470-5649 58.2 µM -0.182930840635869 0.471640785598935 no 1786 0.427426141930498 2815 4108395
SGTC_971 1315-0384 26.7 µM -0.183621523684573 0.471358199241414 no 1787 0.427155188381112 2768 6769120
SGTC_2174 5790901 200 µM -0.185278617222861 0.470680274352263 no 1788 0.426505254323285 2817 786020
SGTC_3330 9141424 71.43 µM -0.185362654171264 0.47064589668195 no 1789 0.426472299218914 2863 27261020
SGTC_1809 st050081 57.6 µM -0.186116433199452 0.470337552044456 no 1790 0.426176727617375 2885 5036894
SGTC_1983 st071813 46.9 µM -0.186822995063063 0.470048538442319 no 1791 0.425899708441338 2801 11838595
SGTC_1822 st052468 42 µM -0.187550627101723 0.46975092274205 no 1792 0.425614466575223 2773 2873678
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.187955825909771 0.469585195838642 no 1793 0.425455639877892 2885 5282362
SGTC_1159 4092-0538 61.2 µM -0.188749570440737 0.469260568464316 no 1794 0.425144549108658 2753 717301
SGTC_2831 7999036 19.48 µM -0.189378827181518 0.469003228176165 no 1795 0.424897958831687 3041 2988270
SGTC_722 3534-0461 190 µM -0.190008288539296 0.468745817163504 no 1796 0.424651317768573 2785 658262
SGTC_1150 3909-7983 10.9 µM -0.19002656792718 0.468738342211883 no 1797 0.424644155818968 2766 23965914
SGTC_1635 st007035 42.4 µM -0.190907100558557 0.468378280955931 no 1798 0.424299188523949 2737 3716403
SGTC_521 r062-0005 13.8 µM -0.192304879876654 0.467806764031912 no 1799 0.42375169807564 2707 2832033
SGTC_1766 st045414 44.774 µM -0.192643964881063 0.467668130629282 no 1800 0.423618905399368 2738 253960
SGTC_1311 1190-0148 100 µM -0.193027387067132 0.467511374891153 no 1801 0.423468759819257 2865 1961333
SGTC_343 4130-2827 29.8 µM -0.193872763246974 0.467165774834897 no 1802 0.423137755414113 2795 1118244
SGTC_3322 9139058 2.11 µM -0.194274993901716 0.467001346728818 no 1803 0.422980282287784 2919 4908926 YPR165W RHO1
SGTC_1739 st037196 92.5 µM -0.196578578700329 0.466059772263601 no 1804 0.422078667615342 2884 612214
SGTC_2425 5628681 7.85 µM -0.196605636806479 0.466048713566917 no 1805 0.422068079587949 2837 5714958
SGTC_996 3970-0799 1.8 µM -0.196762204253745 0.465984724684386 no 1806 0.422006814749921 2830 6615648 YGL040C HEM2
SGTC_3036 9090181 49.47 µM -0.197015913273552 0.465881036053555 no 1807 0.421907542424802 2729 25236586
SGTC_1452 4194-0072 190 µM -0.197381572082998 0.465731598610868 no 1808 0.42176447464918 2931 1343545
SGTC_321 4534-3890 65.3 µM -0.197644810288292 0.46562402141094 no 1809 0.421661486381113 2879 699746
SGTC_1324 1418-0026 34.4 µM -0.197848108107266 0.465540941686031 no 1810 0.421581952617857 2854 1372513
SGTC_1252 0493-0875 34.8 µM -0.198132475415209 0.465424734608957 no 1811 0.421470708379897 2734 3960963
SGTC_549 1661-1316 519 µM -0.198705783163867 0.465190460612172 no 1812 0.421246449962969 2851 2857282
SGTC_2641 levomentholum 100 µM -0.198731382845943 0.465179999949686 no 1813 0.421236436836675 2765 16666
SGTC_1011 4112-3381 17.4 µM -0.198951295616813 0.465090139150942 no 1814 0.421150421682038 2925 2877139
SGTC_491 tetrandrine 80.3 µM -0.19932524423726 0.464937340283565 no 1815 0.421004166656903 2851 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1104 tacrolimus 29.8 µM -0.199710503796802 0.464779925068976 no 1816 0.420853499211826 2747 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3146 9095609 49.47 µM -0.199838975627671 0.464727433317246 no 1817 0.420803258978916 2832 17173999
SGTC_2825 7998094 58.44 µM -0.199972041108606 0.464673065313011 no 1818 0.420751223711675 2841 2987815
SGTC_1514 1189-1591 158 µM -0.200132477314125 0.464607515032575 no 1819 0.420688486961526 2968 767698 YMR146C TIF34
SGTC_2281 7943571 200 µM -0.20147368898293 0.464059566741219 no 1820 0.420164100376187 2911 1244024
SGTC_615 k087-0205 167 µM -0.201941501489405 0.463868459225795 no 1821 0.419981228446601 2780 9642773
SGTC_1488 4013-0813 75.9 µM -0.202681780265918 0.463566062733412 no 1822 0.419691882423072 2768 2910057
SGTC_1706 st031321 9.9705 µM -0.202755485798967 0.463535955908068 no 1823 0.419663076186361 2865 6103185
SGTC_593 1203-0218 61.7 µM -0.207498259291463 0.461599100899829 no 1824 0.417810375987975 2906 3666956
SGTC_2765 myclobutanil 7.74 µM -0.20782464429594 0.461465844669599 no 1825 0.417682944674304 2874 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2340 7987427 183.45 µM -0.208159928140772 0.461328959732125 no 1826 0.417552047964445 2898 2239331
SGTC_1017 4239-0030 168 µM -0.208290699907656 0.461275571329083 no 1827 0.417500996402443 2803 1149593
SGTC_3191 9110352 49.47 µM -0.208443604395439 0.461213147987525 no 1828 0.417441306283527 2729 17122424
SGTC_2771 fluoxetine 41.05 µM -0.209163629874921 0.460919210058963 no 1829 0.417160251792037 2955 3386 A selective serotonin reuptake inhibitor.
SGTC_2330 7979373 200 µM -0.211727645971352 0.459872669397217 no 1830 0.416159759332179 2796 1863007
SGTC_1882 5615643 20 µM -0.211873560470046 0.459813120551647 no 1831 0.416102839003764 2738 2253075
SGTC_2553 4-methylesculetin 85.09 µM -0.212835584221038 0.459420533778087 no 1832 0.415727603688209 2820 5319502
SGTC_1502 4534-4282 27.7 µM -0.212916514611011 0.459387509156795 no 1833 0.415696040460514 2811 3278949
SGTC_20 0481-0013 4.944 µM -0.214724920291602 0.458649640929968 no 1834 0.414990896075137 2789 182045
SGTC_2457 5731572 11.68 µM -0.215740178374236 0.458235456172964 no 1835 0.414595140404121 2944 2865357
SGTC_2175 5807670 165.306 µM -0.215857700562541 0.458187514732632 no 1836 0.414549334910706 2891 241186
SGTC_2960 9079389 5.97 µM -0.216075414009745 0.458098703356237 no 1837 0.414464481904243 2944 16457355
SGTC_1342 1486-1464 234 µM -0.2162261197433 0.458037227516723 no 1838 0.414405747242633 2801 3253938
SGTC_1721 st082152 9.2685 µM -0.216931191838732 0.457749628068146 no 1839 0.414130984395763 2757 5296051
SGTC_1994 st072947 40.9 µM -0.21712942259723 0.457668773567247 no 1840 0.414053742485625 2884 5286565 YDL195W SEC31
SGTC_3213 9129884 49.47 µM -0.218880375886014 0.456954669966748 no 1841 0.413371616798984 2893 17190742
SGTC_2829 7992743 58.44 µM -0.219094282716595 0.456867440318847 no 1842 0.41328830215858 2997 16462845
SGTC_96 0929-0093 37.281 µM -0.219672692190501 0.456631579566765 no 1843 0.413063036829802 2792 6991579
SGTC_936 3005-4620 401 µM -0.220014442648454 0.456492229549909 no 1844 0.412929953339125 3002 777207
SGTC_1208 2323-2347 50.3 µM -0.220195662233939 0.456418338761539 no 1845 0.412859387382751 2953 5412760
SGTC_2155 5570423 76 µM -0.221656817525097 0.455822620046675 no 1846 0.412290524242979 2813 797402
SGTC_3240 9133527 49.47 µM -0.22347186591615 0.455082756173003 no 1847 0.411584138616648 2833 17617455
SGTC_2105 5350118 200 µM -0.22378976063127 0.454953189462252 no 1848 0.411460448876333 2846 2133313
SGTC_1710 st031758 61.5 µM -0.223790525673986 0.454952877653883 no 1849 0.411460151216265 2962 5394341
SGTC_465 cgp-37157 41 µM -0.225029493176348 0.454447948369044 no 1850 0.41097816518529 2893 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_455 paf C-16 10 µM -0.225078157619343 0.454428117140449 no 1851 0.410959236367821 2785 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_584 0986-0246 15.4 µM -0.225248503739527 0.454358700353106 no 1852 0.410892979139132 2789 53315 YDR232W HEM1
SGTC_1615 st002656 86.5 µM -0.226475899420263 0.453858572593402 no 1853 0.410415650888304 2781 1584458
SGTC_3112 9123419 49.47 µM -0.229607274135005 0.452582962435869 no 1854 0.409198476970301 2792 17015854
SGTC_1122 capsaicin 818.572 nM -0.229853593340356 0.452482641378589 no 1855 0.409102768987883 2950 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1498 4478-3555 97.6 µM -0.229986206701743 0.452428631772301 no 1856 0.409051243957153 2823 3437919
SGTC_1301 naphtanilide LB 4.81 µM -0.231073621520159 0.451985792296938 no 1857 0.408628803785382 2942 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_705 1124-0212 310 µM -0.232046092249579 0.451589813300022 no 1858 0.408251107111816 2919 9554485
SGTC_1197 1601-0112 267 µM -0.232186621961551 0.451532595176498 no 1859 0.408196533994539 2824 7350313
SGTC_2706 st078239 82.5 µM -0.234802317317546 0.450467772848508 no 1860 0.407181084530422 2815 15434492
SGTC_1496 4469-0713 57.4 µM -0.234879139128405 0.450436504840259 no 1861 0.407151270622956 2939 746691
SGTC_1100 amiodarone 5.07 µM -0.235891525198744 0.450024472343356 no 1862 0.406758422308647 2934 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2634 4'-methoxyflavone 100 µM -0.237481866632273 0.449377325880619 no 1863 0.406141492607085 2895 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1565 sinapyl alcohol 95.1 µM -0.237879607262135 0.449215497059906 no 1864 0.405987236307307 2910 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1792 st045773 43.6 µM -0.237899638236939 0.449207347275823 no 1865 0.405979468052394 2818 2919270
SGTC_897 1000-0139 31.4 µM -0.238421961079625 0.448994843056367 no 1866 0.405776917997207 2973 6151020
SGTC_2904 7225135 42.03 µM -0.238463983920343 0.448977746926314 no 1867 0.405760623177658 2919 4446116
SGTC_2384 9036245 200 µM -0.238955105167367 0.448777951360609 no 1868 0.405570197615143 2871 6462766
SGTC_2591 skatole 100 µM -0.238969757369098 0.448771990822197 no 1869 0.405564516766913 2968 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2348 9022543 33.42 µM -0.239161069938119 0.448694165633702 no 1870 0.405490344233883 2962 3162678 YDL140C RPO21
SGTC_866 0495-0101 262 µM -0.241376940457922 0.447792902978408 no 1871 0.40463149165048 2823 635694
SGTC_1441 4106-0040 13 µM -0.242805618680037 0.447211958205417 no 1872 0.404077991364669 2827 2904180
SGTC_606 k015-0008 38.6 µM -0.243400495474538 0.44697009621466 no 1873 0.403847580007522 2974 1970475
SGTC_65 0798-0905 34.986 µM -0.246845611867105 0.445569788884433 no 1874 0.402513854665054 3243 3602145
SGTC_1634 st006576 41 µM -0.248023635489388 0.445091122431312 no 1875 0.402058059785443 3016 3915356
SGTC_918 glabranin 770.725 nM -0.248473667875862 0.444908281820909 no 1876 0.401883970672327 2892 124049 Also referred to as licorice root.
SGTC_1275 0867-0008 21.1 µM -0.249047959341055 0.444674973857327 no 1877 0.401661841842246 2831 3422836
SGTC_903 1134-0042 114 µM -0.250062335579441 0.444262926752593 no 1878 0.401269571323789 2850 701009
SGTC_97 0535-0701 19.132 µM -0.250479955511431 0.444093303936959 no 1879 0.401108101963979 2867 2832013 YGL099W LSG1
SGTC_2053 5265679 138 µM -0.250669850958436 0.444016178339466 no 1880 0.401034686013859 2837 764595
SGTC_2852 9023854 51.95 µM -0.250753618471122 0.44398215703127 no 1881 0.40100230155849 2990 19798528
SGTC_942 3253-1115 227 µM -0.251380174114207 0.443727701050549 no 1882 0.400760097219846 3037 46497897
SGTC_266 formosanin C 406 nM -0.251386764349066 0.443725024755856 no 1883 0.400757549869781 2966 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_409 arachidonic acid 100 µM -0.252169830979561 0.443407039664369 no 1884 0.400454898037614 2859 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1418 3966-3099 2.4 µM -0.253008447433142 0.443066537499285 no 1885 0.400130842712552 2936 740335
SGTC_1269 0831-0796 3.05 µM -0.253712331851322 0.442780772819468 no 1886 0.399858903143797 2969 927758
SGTC_2868 9035608 32.47 µM -0.253764087396146 0.442759762152495 no 1887 0.399838909758176 2798 6462614
SGTC_3015 9080845 49.47 µM -0.253897424096486 0.442705633563412 no 1888 0.3997874024373 2979 5296973
SGTC_1151 3909-8316 15.3 µM -0.254504214364255 0.442459318047895 no 1889 0.399553024335044 2964 800431
SGTC_2025 5147754 141 µM -0.255438732021937 0.442080011073471 no 1890 0.399192129453618 2940 315777 YLR208W SEC13
SGTC_3264 9137442 49.47 µM -0.255516213920028 0.44204856468945 no 1891 0.399162211120717 3096 17015726
SGTC_1906 st060206 94.7 µM -0.25650853742773 0.44164585799585 no 1892 0.398779094501764 3014 5133468
SGTC_1080 nisoldipine 24.4 µM -0.257227087824458 0.441354292073301 no 1893 0.3985017371496 2821 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3085 9117376 49.47 µM -0.257998906170835 0.441041147039539 no 1894 0.398203875702661 2939 16480349
SGTC_2745 rifampicin 24.3 µM -0.258336021469787 0.440904382910323 no 1895 0.398073794193449 2925 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_571 k831-0106 44.2 µM -0.2598171627648 0.44030358319512 no 1896 0.397502405754873 2930 4783639
SGTC_863 0466-0191 129 µM -0.260085166918109 0.440194886520874 no 1897 0.397399039698034 2979 765160 YPR165W RHO1
SGTC_1838 st055369 84.5 µM -0.261475272767575 0.439631162222422 no 1898 0.396863007942806 2843 676036
SGTC_1674 st016616 23.6 µM -0.261697637125102 0.439540998981163 no 1899 0.396777281184016 2803 625830
SGTC_1140 3229-1848 2.98 µM -0.261986794081913 0.439423757685875 no 1900 0.39666581174827 2978 2849525
SGTC_2408 sulbentine 18.36 µM -0.26344209824108 0.438833772360978 no 1901 0.396104923241064 2921 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2207 7258803 200 µM -0.264353272510633 0.438464448254824 no 1902 0.39575385710969 2948 3666799
SGTC_2508 celastrol 40.54 µM -0.264404261794134 0.438443782469553 no 1903 0.395734213955631 2887 122724 Celastrol is a natural product and antioxidant.
SGTC_3121 9125696 49.47 µM -0.265800426265158 0.437877987107208 no 1904 0.395196457454715 2880 1235365
SGTC_648 0375-0473 33.3 µM -0.266046050563616 0.437778461013187 no 1905 0.395101871688058 2885 1713139
SGTC_1414 3917-0015 5.4 µM -0.266217285120352 0.43770907970667 no 1906 0.395035935809895 2954 6618702
SGTC_295 k015-0027 31 µM -0.267440513670827 0.437213504300473 no 1907 0.394565004816115 2948 3887424
SGTC_2081 5214970 32.255 µM -0.267691704408893 0.437111749749319 no 1908 0.394468317887747 2982 2063512
SGTC_670 4204-0025 119 µM -0.268196710316507 0.436907190114816 no 1909 0.394273953529036 2987 719039
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.269571476464189 0.436350407672173 no 1910 0.393744973336929 2856 2333 A French combination drug.
SGTC_2407 paclitaxel 400 µM -0.269895105642053 0.436219355643021 no 1911 0.393620476316146 3112 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_113 0099-0221 2.5 µM -0.269931438980717 0.436204643074769 no 1912 0.393606499910181 3067 89219
SGTC_166 k072-0058 166.424 µM -0.270421139889427 0.436006355631229 no 1913 0.393418139225901 2958 5846229
SGTC_138 0850-0259 40.9225 µM -0.271457476599611 0.435586780023219 no 1914 0.393019600468867 2966 6813004
SGTC_583 1488-1091 88.9 µM -0.272340526810159 0.435229321813628 no 1915 0.392680098765008 2959 4303273
SGTC_1627 st003713 25.6 µM -0.273800713727732 0.434638355247803 no 1916 0.392118887548321 2965 16195070 YER133W GLC7
SGTC_1499 4480-0877 67.3 µM -0.274370595147867 0.43440775248894 no 1917 0.391899918960345 2885 2861909
SGTC_3195 9113082 49.47 µM -0.274576248576473 0.434324540217262 no 1918 0.391820908045771 2954 17018038
SGTC_1964 st076914 61 µM -0.275681929570368 0.433877205339679 no 1919 0.391396188049251 2865 24208661
SGTC_1680 diphenhydramine 100 µM -0.275850120518062 0.433809166285775 no 1920 0.391331592988894 2938 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2935 9038016 29.96 µM -0.276096842417588 0.433709362295591 no 1921 0.391236842919848 3041 6463195
SGTC_3099 9120367 49.47 µM -0.276234537320516 0.433653663764205 no 1922 0.391183965938382 2880 24824940
SGTC_230 MPP+ 141.667 µM -0.277459754568844 0.433158113139523 no 1923 0.390713552158199 2937 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2428 5615643 7.78 µM -0.277489035651085 0.433146271413355 no 1924 0.390702311840636 3021 2253075
SGTC_1195 1502-0147 41.1 µM -0.278683237394901 0.432663368873243 no 1925 0.390243963847175 2907 817940
SGTC_2883 9059145 45.46 µM -0.279753601993771 0.43223062811912 no 1926 0.389833275529414 2847 16476510
SGTC_1480 1070-0044 41.2 µM -0.28044127860472 0.431952648238624 no 1927 0.389569485657682 2981 3124987
SGTC_2921 7974240 10.71 µM -0.280759652435894 0.431823963216559 no 1928 0.389447376007343 3028 2979074 YDR527W RBA50
SGTC_2743 auranofin 4.32 µM -0.281820255162274 0.431395325457279 no 1929 0.389040669407782 2940 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_172 1112-0046 2.638 µM -0.281937402013989 0.431347986035577 no 1930 0.388995754852204 2932 2802135 YIL048W NEO1
SGTC_1440 4100-1550 40 µM -0.282248505624819 0.431222272848635 no 1931 0.388876483727997 2923 742806
SGTC_532 1548-0774 215 µM -0.282875021333044 0.430969126623722 no 1932 0.388636321481103 3106 5932993
SGTC_551 k048-0028 34.9 µM -0.282950276108578 0.430938721530677 no 1933 0.388607476931678 3062 6836383
SGTC_1917 st066507 28.5 µM -0.284704255729905 0.430230179651181 no 1934 0.387935364964168 2914 3156428
SGTC_1459 k035-0031 35.7 µM -0.286679643807149 0.429432466085693 no 1935 0.387178812769915 2872 3877128 YMR208W ERG12
SGTC_36 0335-0881 14.2 µM -0.289404339509798 0.428332635763325 no 1936 0.386135987284929 2904 23828853
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.289824023106209 0.428163278657112 no 1937 0.3859754342444 2941 65057 A dermal irritant. YDR527W RBA50
SGTC_2812 7970281 58.44 µM -0.29099600886857 0.427690411301021 no 1938 0.38552718597683 3064 2233435
SGTC_1046 2001-0062 216 µM -0.291216010603114 0.427601657581926 no 1939 0.385443059146826 2902 739778
SGTC_1051 3253-3903 78 µM -0.291219149957448 0.427600391121264 no 1940 0.385441858722884 2862 5509239
SGTC_372 0155-0182 15.9 µM -0.29273186966194 0.426990225271628 no 1941 0.384863553978623 2908 771486
SGTC_2515 chrysin 20.77 µM -0.293568207263014 0.426652957648636 no 1942 0.384543936363593 3000 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_32 0928-0142 34.1 µM -0.294430838786123 0.426305142725145 no 1943 0.384214352378961 3010 2244242
SGTC_194 1486-1323 56.904 µM -0.294562105130904 0.426252220864213 no 1944 0.384164207028096 2967 5178754
SGTC_1834 st055981 52.8 µM -0.29511687220927 0.426028573442438 no 1945 0.383952300633957 3078 471719 YDL150W RPC53
SGTC_352 k048-0007 5.11 µM -0.295856228228608 0.425730548285717 no 1946 0.383669940067548 3018 6811911
SGTC_256 clotrimazole 625 nM -0.297171240378122 0.425200588276772 no 1947 0.383167888726481 2990 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_411 enrofloxacin 100 µM -0.297582597455891 0.425034835913685 no 1948 0.38301087918393 3090 71188 A bacterial gyrase inhibitor.
SGTC_1356 1502-0781 85.8 µM -0.297640562348118 0.42501148058452 no 1949 0.382988756297422 2936 567702
SGTC_2810 7959871 45.46 µM -0.297960670723978 0.424882506626218 no 1950 0.382866590578807 3031 2974535
SGTC_2772 vinpocetine 57.06 µM -0.298135693819713 0.424811991965938 no 1951 0.382799799932392 3134 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_535 2293-4129 48.2 µM -0.30007031296124 0.424032718386828 no 1952 0.382061761587214 3094 396118 YIL048W NEO1
SGTC_1125 tnp00248 1.32998 µM -0.30201779670807 0.423248562781462 no 1953 0.381319248130774 3096 24207736
SGTC_3207 9114163 49.47 µM -0.302565787621474 0.42302796854011 no 1954 0.381110395268233 3205 849233
SGTC_424 splitomicin 100 mM -0.302663504933975 0.422988634880095 no 1955 0.381073156424669 3022 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2436 5633522 8.09 µM -0.303382284393286 0.422699331803153 no 1956 0.380799272444127 3121 5724242
SGTC_1591 genipin 88.4 µM -0.3037152076649 0.422565346922746 no 1957 0.38067243547047 3064 442424 A DNA cross-linking agent.
SGTC_968 1309-0633 340 µM -0.305194717338432 0.421970027232961 no 1958 0.380108927779394 3045 3761976
SGTC_1933 st074711 15.9 µM -0.306157382028634 0.421582769375712 no 1959 0.379742409767303 2905 17250958
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.3068109649616 0.421319891193894 no 1960 0.379493630853117 2872 6708630 An antioxidant.
SGTC_576 1073-0113 22.7 µM -0.307454415171731 0.421061122758841 no 1961 0.379248757571947 3010 5439563
SGTC_906 1165-0455 526 µM -0.308206494715709 0.420758711429459 no 1962 0.378962605398048 2942 3252859
SGTC_72 0744-0168 198.391 µM -0.308245079086963 0.420743197905752 no 1963 0.378947926555074 2904 677577
SGTC_2484 5809818 12.04 µM -0.308998729917554 0.420440204071919 no 1964 0.378661246478922 2976 2870548
SGTC_764 1951-2361 146 µM -0.309594270288473 0.420200809469622 no 1965 0.378434757005076 2958 5438930
SGTC_3262 9137218 49.47 µM -0.310474998558538 0.419846829509273 no 1966 0.378099884510842 2867 17650664
SGTC_3293 9120939 62.045 µM -0.31058301085372 0.41980342195303 no 1967 0.378058822129773 3097 934087
SGTC_2101 5377231 179.231 µM -0.311705732067072 0.419352285042843 no 1968 0.377632085649013 3095 2844213
SGTC_2106 5357045 167.29 µM -0.313543256600456 0.418614151594567 no 1969 0.376933981093091 3041 668842
SGTC_2568 diosmetin 100 µM -0.314012070467341 0.41842587486758 no 1970 0.376755935605692 3134 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2612 dictamnine 15.46 µM -0.314894337969568 0.418071604919234 no 1971 0.376420940363512 3036 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3030 9087619 49.47 µM -0.315914162654433 0.417662182428545 no 1972 0.376033830893554 3008 25236973
SGTC_1963 st076565 50.3 µM -0.316411565457114 0.417462525656297 no 1973 0.375845069802826 2978 4914280
SGTC_2903 5923464 63.88 µM -0.319430798639135 0.416251068150369 no 1974 0.374699929605864 3053 2876576
SGTC_3194 9111903 49.47 µM -0.32037828378166 0.41587105620185 no 1975 0.374340792857151 3177 17087251
SGTC_1975 st070967 30.8 µM -0.321868949762815 0.415273347712042 no 1976 0.373775988465672 3143 261391
SGTC_991 3996-0057 64.7 µM -0.322139117344243 0.415165040257295 no 1977 0.37367365255916 3056 715343
SGTC_2923 7992654 58.14 µM -0.323222603902365 0.414730746288074 no 1978 0.373263331727889 3008 2985126
SGTC_3048 9093155 49.47 µM -0.323572408128043 0.414590556469212 no 1979 0.373130890083122 3081 25236002
SGTC_2679 rapamycin 1 nM -0.323963704398274 0.414433750919303 no 1980 0.372982756629461 3049 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_635 k038-0028 24.7 µM -0.324565465708851 0.41419263158144 no 1981 0.372754983846667 3019 4035102
SGTC_2047 4141938 200 µM -0.325871169305991 0.41366956140238 no 1982 0.372260914811061 3009 3807862
SGTC_1691 st019933 84.6 µM -0.326189140587849 0.413542203965751 no 1983 0.372140628514958 3070 6176082
SGTC_3157 9099274 49.47 µM -0.327216205609538 0.413130894523728 no 1984 0.371752182334174 3113 17217662
SGTC_3033 9090887 49.47 µM -0.327795023852564 0.41289913675238 no 1985 0.371533325015746 2978 19325384
SGTC_1227 3909-8010 46.6 µM -0.328135277243648 0.412762914075263 no 1986 0.371404690972283 2988 15982272
SGTC_1530 rhein 70.4 µM -0.32870070700702 0.412536563802169 no 1987 0.371190959943152 2967 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2891 9063876 19.48 µM -0.328920937976229 0.412448409807418 no 1988 0.371107723935193 3080 6472478
SGTC_1703 st026983 48.3 µM -0.329546278997943 0.412198122555188 no 1989 0.370871409988528 3129 1104023
SGTC_1034 k072-0165 12.7 µM -0.32999059706957 0.412020309841175 no 1990 0.370703533498336 3144 5835461
SGTC_1957 st077035 62.4 µM -0.330080669291332 0.411984265823523 no 1991 0.370669504552196 3096 705593
SGTC_5 0352-0601 109.883 µM -0.330086773617403 0.411981823094646 no 1992 0.3706671983974 3039 762456
SGTC_826 1683-5028 118 µM -0.330557975012576 0.411793275764374 no 1993 0.370489197139648 3066 722377
SGTC_1891 st059073 26.2 µM -0.330664218344888 0.411750766187939 no 1994 0.370449066437985 3167 688754
SGTC_1830 st055982 50.3 µM -0.331470244949076 0.411428296429333 no 1995 0.370144656450332 3113 455313 An antimicrobial agent.
SGTC_2657 nystatin 74.44 µM -0.33291758546096 0.410849404368149 no 1996 0.369598247323277 3051 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_543 3844-1095 191 µM -0.333292263453737 0.41069957617865 no 1997 0.369456839371574 3066 4230703
SGTC_807 1315-0151 48 µM -0.334318027794228 0.41028945491189 no 1998 0.369069794047774 3208 4011080
SGTC_2144 5628481 200 µM -0.336118917917349 0.409569660270074 no 1999 0.368390596537665 3004 2818399
SGTC_3321 9137793 26.8275 µM -0.336313422949456 0.409491937081252 no 2000 0.368317264408028 3049 4904192
SGTC_1997 st073024 93.8 µM -0.336345230772537 0.409479227180618 no 2001 0.368305272704631 3137 686268
SGTC_384 k007-0144 5.16 µM -0.336462063267068 0.409432543589044 no 2002 0.368261227389305 3043 6824886
SGTC_847 0342-0274 5.54 µM -0.336620489613345 0.409369242097543 no 2003 0.36820150414816 3125 18097
SGTC_773 4358-1457 44.6 µM -0.33746569030964 0.409031570152678 no 2004 0.367882935965072 3173 1186886
SGTC_2986 9022445 71.43 µM -0.337509091577704 0.409014232433397 no 2005 0.367866579859519 3165 6459286
SGTC_329 k048-0121 21.3 µM -0.339354549084447 0.408277183519479 no 2006 0.367171326872445 3068 6832902
SGTC_1513 0337-0559 19 µM -0.339449134724044 0.4082394161062 no 2007 0.367135704626651 3020 775073
SGTC_2673 kobusone 100 µM -0.34043736370565 0.407844873923723 no 2008 0.366763592524734 3018 6710676 An epoxy ketone and protein crosslinker.
SGTC_1306 1185-0270 9.02 µM -0.340610036430331 0.407775945356032 no 2009 0.366698586411934 3119 1548076
SGTC_2843 9000894 45.46 µM -0.34145065078494 0.407440424524693 no 2010 0.366382174908592 3076 2242070
SGTC_1289 0976-0073 69.1 µM -0.342791058740861 0.406905557788405 no 2011 0.365877826481712 3117 3391136
SGTC_1493 4348-0038 111 µM -0.343291208646336 0.406706025988772 no 2012 0.365689696952204 3079 800424
SGTC_601 0986-0029 62.9 µM -0.344503876628624 0.406222340022507 no 2013 0.365233690568776 3025 24747981
SGTC_1219 1469-0211 33.1 µM -0.344889128804209 0.406068707866738 no 2014 0.365088861857406 3133 6822282
SGTC_93 0109-0045 59.227 µM -0.345051496908007 0.406003962500208 no 2015 0.365027828215994 3042 88733
SGTC_410 α-linolenic acid 100 µM -0.345365583135161 0.405878725815626 no 2016 0.364909773932051 3129 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1173 0443-0020 122 µM -0.345646958285905 0.405766540310281 no 2017 0.364804025498262 3005 5331295
SGTC_2277 7947813 106.88 µM -0.345735458580492 0.405731256454509 no 2018 0.364770766806431 3218 1246798
SGTC_3270 9137563 49.47 µM -0.346804589348355 0.405305069245992 no 2019 0.364369064536984 3095 17015724
SGTC_3128 9127691 49.47 µM -0.347004290851894 0.405225474736023 no 2020 0.36429404760188 3126 41316314
SGTC_2472 5377652 49.4 µM -0.347044329407769 0.405209517144338 no 2021 0.364279007931267 3048 1610903
SGTC_2343 7990716 14.84 µM -0.34715690628069 0.40516464984287 no 2022 0.364236721834516 2988 6456862
SGTC_1945 st075991 56.6 µM -0.347189055704707 0.405151836979024 no 2023 0.364224646179273 3047 1084980
SGTC_2618 avocadyne 43.43 µM -0.348162604864398 0.404763885928664 no 2024 0.363859034965258 2958 3015189
SGTC_2683 piperine 63.03 µM -0.348906549895758 0.404467493233928 no 2025 0.363579733862777 3037 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2024 5144227 134 µM -0.349101965126716 0.404389647577659 no 2026 0.363506380660313 3161 3475211
SGTC_2932 9016711 44.54 µM -0.349489437702157 0.404235305109536 no 2027 0.363360949508528 3159 7117328
SGTC_2298 7976326 193.81 µM -0.3502202530495 0.403944239041069 no 2028 0.363086704179865 2984 2235818
SGTC_1355 1499-0035 1.68 µM -0.35183941405762 0.403299556031109 no 2029 0.362479348977464 3020 1548538
SGTC_2586 curcumin 80 µM -0.352254605283369 0.403134286291466 no 2030 0.36232366438599 3133 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3260 9137109 49.47 µM -0.352688715957872 0.402961504037028 no 2031 0.362160909901347 3090 17478346
SGTC_298 1391-0729 10 µM -0.352859747190694 0.402893436362314 no 2032 0.362096794614208 3024 3237558
SGTC_2847 9005661 71.43 µM -0.353742436561669 0.402542187047017 no 2033 0.361765958225883 3106 2991449
SGTC_1746 st038117 42 µM -0.35379975958471 0.402519379165818 no 2034 0.361744476839445 3111 2898218
SGTC_1909 st060837 51.5 µM -0.354214392714436 0.402354413397413 no 2035 0.361589109062628 3054 678937
SGTC_1974 st069448 26.9 µM -0.354791139665794 0.402124978011046 no 2036 0.361373033330012 3168 6323587 YNR016C ACC1
SGTC_203 k066-0004 30.888 µM -0.356165160635601 0.401578515482725 no 2037 0.360858440598613 3111 6795412
SGTC_1170 0310-0127 64.8 µM -0.357405485189145 0.401085390621086 no 2038 0.360394135494262 3086 774975
SGTC_1326 1431-2094 10.8 µM -0.357965975063061 0.400862604214868 no 2039 0.360184388274385 2967 616278
SGTC_2268 7933382 153.85 µM -0.358896503352351 0.400492804253938 no 2040 0.359836257764944 3010 935025 YOR257W CDC31
SGTC_747 3448-8087 38.7 µM -0.359295376588623 0.400334315879124 no 2041 0.359687066345334 3077 5168703
SGTC_891 0929-0073 133 µM -0.359483311678285 0.400259647397353 no 2042 0.359616779985598 3165 5603632
SGTC_1192 1488-0095 21.4 µM -0.359767883657221 0.400146591057867 no 2043 0.359510361169776 3112 915875
SGTC_2479 5617353 43.85 µM -0.359991594417172 0.400057719876421 no 2044 0.359426709723328 3200 2731746
SGTC_3071 9117417 49.47 µM -0.360063593027045 0.400029118859265 no 2045 0.359399788946965 3058 45595590 YGL055W OLE1
SGTC_1608 st001473 40.5 µM -0.360990183456885 0.399661084262925 no 2046 0.35905339272787 3048 7292267
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.361402926222544 0.39949717468344 no 2047 0.358899130406244 3185 5377381
SGTC_2085 5307070 144.047 µM -0.361674895725115 0.399389179061199 no 2048 0.358797494568245 3013 2840351
SGTC_3133 9127736 49.47 µM -0.361877485503206 0.399308738245719 no 2049 0.358721792642737 3235 27243420
SGTC_2206 7254556 146.969 µM -0.361908911509411 0.39929626053823 no 2050 0.358710050152631 3083 4398905
SGTC_426 0988-0037 14.6 µM -0.362336019345239 0.399126687418254 no 2051 0.358550472341958 3232 5383008
SGTC_2796 7949634 45.45 µM -0.362481434396334 0.39906895813432 no 2052 0.3584961473978 3004 2971588
SGTC_330 1488-0319 80.1 µM -0.364317871053577 0.398340089363983 no 2053 0.357810328178228 3117 6846614
SGTC_1646 st011709 75.6 µM -0.364412204917963 0.398302658469782 no 2054 0.357775111465458 3155 5757843
SGTC_2374 9071832 200 µM -0.364826564605494 0.398138255072356 no 2055 0.357620437072032 3049 17381698
SGTC_815 1582-0027 36.9 µM -0.364922004560676 0.398100390405091 no 2056 0.357584814048655 3138 3128206
SGTC_2654 protoveratrine a 100 µM -0.365105474356946 0.398027603640997 no 2057 0.357516337316804 3057 5702278 A heart drug and vasodilator.
SGTC_865 0488-0499 301 µM -0.365312559060951 0.397945452553389 no 2058 0.357439052264841 3205 9634651
SGTC_414 piperonyl butoxide 100 µM -0.366632113287305 0.397422088075057 no 2059 0.356946725437201 3048 5794 A potent inhibitor of cytochrome P450.
SGTC_14 0354-0009 295 µM -0.368578443887585 0.396650467400491 no 2060 0.356220982663919 3048 1713507
SGTC_2294 7971431 200 µM -0.369147474190084 0.39642495223866 no 2061 0.356008902316043 3162 5741572
SGTC_1897 st060201 15 µM -0.369735852970867 0.396191805422363 no 2062 0.35578965753913 3074 611878
SGTC_2997 9067075 71.4286 µM -0.371003096112052 0.395689782796463 no 2063 0.355317612831714 3140 27209819
SGTC_324 1315-0088 19.6 µM -0.372331419931173 0.395163748574139 no 2064 0.35482305392483 3134 6787421
SGTC_1218 1348-1416 30.7 µM -0.373071033430379 0.39487093433035 no 2065 0.354547788422104 3044 6787668
SGTC_2934 9036370 36.88 µM -0.373730494958256 0.394609902450649 no 2066 0.354302417503043 3146 6462800
SGTC_1871 st057448 67.3 µM -0.374526713449893 0.394294801692012 no 2067 0.354006242954071 3273 691747
SGTC_713 1488-1073 324 µM -0.37556844145148 0.393882645850187 no 2068 0.353618878016995 3086 3312542
SGTC_202 3594-0513 34.79 µM -0.376618981241215 0.393467123999176 no 2069 0.353228389882276 3075 708429
SGTC_2709 st078560 56 µM -0.376810523773865 0.393391375905208 no 2070 0.35315720970649 3237 17250903
SGTC_2164 5685496 200 µM -0.376993415115192 0.393319052808024 no 2071 0.353089249241998 3200 759046
SGTC_2162 5663267 200 µM -0.377176937970859 0.393246483683186 no 2072 0.35302105882347 3217 6456493
SGTC_3342 9147791 14.508 µM -0.379493627974996 0.392330731319168 no 2073 0.352160667592466 3066 1838168
SGTC_135 0933-0004 26.348 µM -0.379889419857515 0.392174340262153 no 2074 0.352013750686936 3188 21230617 YGL099W LSG1
SGTC_693 4161-2696 114 µM -0.381369559993381 0.391589640257185 no 2075 0.351464522479731 3187 805759
SGTC_2979 9012552 45.46 µM -0.382093345044718 0.391303812375508 no 2076 0.351196063948726 3192 17100905
SGTC_1384 3089-0840 101 µM -0.383170306584943 0.390878621247858 no 2077 0.350796746450684 3189 1069836
SGTC_1550 gossypolone 36.6 µM -0.383532460238609 0.390735670005025 no 2078 0.350662503543384 3074 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1177 0983-0204 23.6 µM -0.384662000562584 0.390289906684321 no 2079 0.350243926018978 3219 766818
SGTC_3287 9117173 37.0625 µM -0.38705577321403 0.389345702268996 no 2080 0.34935745925022 3122 2789709
SGTC_3056 9094900 49.47 µM -0.387322018358566 0.389240724256269 no 2081 0.349258913459147 3104 25236784
SGTC_640 3381-0960 37.1 µM -0.389118271455922 0.388532689774039 no 2082 0.348594328932197 3163 1745025
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.389400378613466 0.388421524323725 no 2083 0.348489996001475 3016 4000243
SGTC_2779 methotrexate 400 µM -0.391417621683497 0.387626888478385 no 2084 0.347744284520437 3196 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2699 st077704 54.6 µM -0.392690494425036 0.387125718138952 no 2085 0.347274046099986 3145 645852
SGTC_2152 5568786 200 µM -0.393827604849709 0.386678160771435 no 2086 0.346854161173345 3146 5399883
SGTC_916 4466-0038 42 nM -0.393932841506241 0.386636748092397 no 2087 0.346815311396335 3311 5722064 YGL116W CDC20
SGTC_1296 1068-0102 11.9 µM -0.394172082410342 0.386542606929525 no 2088 0.346726997823846 3180 767053
SGTC_2899 9053889 58.44 µM -0.3946620632889 0.386349820572623 no 2089 0.346546151901377 3203 6470052
SGTC_1996 st072960 66.8 µM -0.39546454999221 0.386034137257882 no 2090 0.346250039468854 3218 1719405
SGTC_1494 4358-1428 177 µM -0.396301497874137 0.385704977932002 no 2091 0.345941311182243 3236 1564571
SGTC_1338 1486-1223 76 µM -0.39645579120913 0.38564430560272 no 2092 0.345884407559121 3148 3444526
SGTC_1004 4084-0029 199 µM -0.397495722940347 0.385235449254348 no 2093 0.345500969957511 3230 716894 YLR208W SEC13
SGTC_2157 5649910 96.377 µM -0.398543427002955 0.384823666122197 no 2094 0.345114826837 3092 2858091
SGTC_632 0781-2353 4.65 µM -0.399276870388974 0.384535475323905 no 2095 0.344844603928387 3185 6811515 YHR007C ERG11
SGTC_1263 0774-1208 64.8 µM -0.399449804787843 0.384467533761851 no 2096 0.344780901145225 3279 906585
SGTC_395 anisomycin 6.25 µM -0.399773420930451 0.38434040268021 no 2097 0.344661704476065 3156 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.400551613515108 0.384034744328201 no 2098 0.344375138022987 3148 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_245 methotrexate 289.6 µM -0.400626435111582 0.384005359711477 no 2099 0.344347589959298 3184 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_290 2043-6722 48.1 µM -0.40084427431687 0.383919811718269 no 2100 0.344267389900093 3215 773758 YLR208W SEC13
SGTC_1442 4112-3290 3 µM -0.401637161490261 0.383608483479388 no 2101 0.343975538338798 3098 704353
SGTC_2052 5265182 7.135 µM -0.40165222333605 0.383602570151401 no 2102 0.343969995166164 3242 1239884
SGTC_39 0986-0283 58.349 µM -0.402145727244319 0.383408833969711 no 2103 0.343788390739195 3290 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_690 glyoxal 20.3 µM -0.402625267711072 0.383220607377702 no 2104 0.343611959239226 3166 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1548 st061468 90.8 µM -0.403515741208904 0.382871156756195 no 2105 0.343284428515156 3213 390799
SGTC_1856 st057054 55.7 µM -0.404454564966481 0.382502835151679 no 2106 0.342939241202791 3310 1266018
SGTC_2185 6113692 200 µM -0.405641827966682 0.382037197461598 no 2107 0.342502895278032 3238 874150
SGTC_10 0279-0212 42.575 µM -0.405970438289509 0.381908348503112 no 2108 0.342382160674928 3142 39851 YBR002C RER2
SGTC_1877 wortmannin 25 µM -0.407292390170344 0.381390140035378 no 2109 0.341896625627479 3243 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2029 5175081 200 µM -0.407381125199155 0.38135536328344 no 2110 0.341864043803895 3115 1380876
SGTC_711 k292-0785 179 µM -0.407916341648851 0.381145623268566 no 2111 0.341667547434287 3107 4146315
SGTC_180 1486-1293 102.781 µM -0.409159920826263 0.380658425756152 no 2112 0.341211152442322 3294 4140536
SGTC_3343 9148379 18.9835 µM -0.409283414244658 0.380610055004607 no 2113 0.341165842878052 3271 1955036
SGTC_1920 st075728 45.7 µM -0.409426808912369 0.380553891536616 no 2114 0.341113234446364 3281 3400306
SGTC_2360 9040895 200 µM -0.409518428388437 0.380518008204301 no 2115 0.341079622840374 3156 4914414
SGTC_1257 0669-0121 16 µM -0.41009980777344 0.380290331356574 no 2116 0.340866366860321 3184 4307855
SGTC_2769 toremifene 3.73 µM -0.410839144581474 0.380000855931221 no 2117 0.340595243903978 3311 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1935 st074532 41.6 µM -0.411631738469941 0.37969060320777 no 2118 0.340304682443783 3215 2829742
SGTC_896 0964-0007 44.5 µM -0.412324058935553 0.379419664835352 no 2119 0.340050958331468 3235 6756758
SGTC_2058 5236698 133 µM -0.412496706145642 0.37935210887733 no 2120 0.33998769723387 3142 766665
SGTC_2326 6164455 177.58 µM -0.413910098209628 0.37879919458428 no 2121 0.339469974060334 3173 2888790
SGTC_1380 2291-0730 164 µM -0.41392079019742 0.378795012857635 no 2122 0.33946605875575 3189 2999191
SGTC_561 1550-0330 72.9 µM -0.414511131418746 0.3785641474567 no 2123 0.339249908296752 3136 6812934
SGTC_1330 1469-0054 61.8 µM -0.414564423404558 0.378543308631546 no 2124 0.339230398306751 3257 7102664
SGTC_3329 9141233 27.5565 µM -0.414733552262299 0.378477176323373 no 2125 0.339168483740537 3273 4909101 YNL103W MET4
SGTC_2183 6420625 130.508 µM -0.41648395960709 0.377792946137245 no 2126 0.338527951247709 3204 2897619
SGTC_2111 5486399 200 µM -0.416586237691972 0.377752977700916 no 2127 0.338490538700007 3146 689674
SGTC_738 1315-0003 72.4 µM -0.416780305926472 0.377677142922788 no 2128 0.338419554393858 3274 6251474
SGTC_2519 cryptotanshinone 88.04 µM -0.416986697449772 0.377596497826908 no 2129 0.338344068900124 3278 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2768 sulfasalazine 50.2 µM -0.417791396609193 0.377282121944276 no 2130 0.338049820847273 3295 5384001 An antioxidant and salicylic acid derivative.
SGTC_1714 st033236 13.627 µM -0.418839188045933 0.376872897863241 no 2131 0.337666831405553 3313 2916566
SGTC_2776 terbinafine 19.92 µM -0.419217954320511 0.376725001397903 no 2132 0.337528425831792 3205 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_574 1315-0397 40 µM -0.420020449751181 0.376411711648931 no 2133 0.337235257349557 3167 6794277
SGTC_523 1934-0222 13.7 µM -0.421814835418522 0.375711488239288 no 2134 0.336580088150647 3138 1361595
SGTC_2536 dehydroabietamide 32.04 µM -0.421912252682393 0.375673484773307 no 2135 0.336544533161659 3293 3983547
SGTC_1058 3448-5425 97.3 µM -0.42282682111008 0.375316761184233 no 2136 0.336210808690596 3190 7279705
SGTC_666 0272-0154 136 µM -0.424567629548177 0.374638060901763 no 2137 0.335575947360196 3187 6870312
SGTC_2140 5586273 200 µM -0.425286297409797 0.374357982279218 no 2138 0.335313990641811 3232 854421
SGTC_890 0929-0006 47.2 µM -0.425946847830561 0.374100611595913 no 2139 0.335073288515942 3152 1378169
SGTC_164 4100-3994 89.624 µM -0.426101686333608 0.374040289884251 no 2140 0.335016875732712 3291 4615967
SGTC_43 0570-0105 72.5 µM -0.426216467853233 0.373995575492269 no 2141 0.33497505943425 3143 1114046 YDL195W SEC31
SGTC_689 0833-0039 98 µM -0.426461853216042 0.373899988637098 no 2142 0.334885669435146 3198 5374726
SGTC_1618 st003135 44.5 µM -0.42802741080731 0.373290327681505 no 2143 0.334315582011782 3218 1270615
SGTC_421 streptovitacin 30 mM -0.429790863872108 0.372603981844055 no 2144 0.333673889669286 3309 91467 include heat shock
SGTC_3235 9132602 49.47 µM -0.431828026186783 0.371811610238276 no 2145 0.332933204225202 3288 4912240
SGTC_1353 1498-1206 8.11 µM -0.432313189551943 0.371622981709604 no 2146 0.332756901133945 3237 6756808
SGTC_839 0122-0028 230 µM -0.43276523916169 0.371447255339941 no 2147 0.332592664495727 3163 759448
SGTC_1020 4335-0961 93.3 µM -0.433036872841076 0.371341675387012 no 2148 0.332493991215397 3108 669075
SGTC_504 lovastatin 124 µM -0.433256521900168 0.371256308157711 no 2149 0.332414210283984 3209 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2690 usnic acid 100 µM -0.434631636926676 0.370722009905065 no 2150 0.331914913671447 3390 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3226 9131256 49.47 µM -0.434807631532184 0.370653645512781 no 2151 0.331851032527586 3214 17178073
SGTC_1686 st019653 115.5 µM -0.434934037821715 0.370604546020969 no 2152 0.331805153578593 3284 97252
SGTC_1216 1165-0504 9.65 µM -0.437548086715976 0.369589654916953 no 2153 0.3308569552357 3293 6304004
SGTC_1772 st048439 82.2 µM -0.438042058443831 0.369397974701895 no 2154 0.330677897646714 3249 2927068 YDL195W SEC31
SGTC_2529 gangaleoidin 93.61 µM -0.438954100197789 0.369044152405491 no 2155 0.330347397557942 3144 4565183
SGTC_3132 9126706 49.47 µM -0.439413022891622 0.368866157446402 no 2156 0.330181145986429 3344 850858
SGTC_1575 cyproterone acetate 48 µM -0.43965058637026 0.368774028567815 no 2157 0.330095098249098 3198 9880 An androgen receptor antagonist and liver toxin.
SGTC_46 0329-0187a 2.197 µM -0.440159086004912 0.368576853989653 no 2158 0.329910945085416 3247 46494817
SGTC_1072 oxiconazole 14.9 nM -0.440379963961683 0.368491217666662 no 2159 0.329830966960797 3261 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_579 4491-1009 110 µM -0.442077945808697 0.367833113589128 no 2160 0.329216401438244 3316 1271041
SGTC_1064 honokiol 6.76 µM -0.442199008280459 0.367786206964928 no 2161 0.329172601826293 3251 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2805 7950783 58.44 µM -0.442512836126764 0.367664621035191 no 2162 0.329059071878659 3267 1178958 YDL195W SEC31
SGTC_224 benfluorex 43.875 µM -0.442711284600804 0.367587743234974 no 2163 0.328987289556425 3284 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2218 6965428 192.983 µM -0.442746263903362 0.367574193003804 no 2164 0.328974637577825 3264 675684
SGTC_3031 9088762 49.47 µM -0.443310368613116 0.367355693722494 no 2165 0.328770628538864 3129 205253
SGTC_3258 9138477 49.47 µM -0.443343321199492 0.367342931255094 no 2166 0.328758712779112 3220 4970355
SGTC_3344 9148862 3.898 µM -0.446620099614601 0.366074575793928 no 2167 0.32757469033091 3331 4905352
SGTC_2195 6536160 144.242 µM -0.446872558431522 0.365976916057229 no 2168 0.327483539241077 3159 3834386
SGTC_525 k781-2675 26.7 µM -0.447095113529893 0.365890831306115 no 2169 0.327403193515404 3299 3651118 YDL195W SEC31
SGTC_2043 5101342 149 µM -0.450156331151618 0.364707433126192 no 2170 0.326298860675364 3209 678451
SGTC_1893 st059353 36.1 µM -0.45069562863666 0.364499085912838 no 2171 0.326104466677879 3247 3112488
SGTC_2003 4023581 200 µM -0.451401604706026 0.364226406129772 no 2172 0.325850063489636 3306 16641307
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.45165519305995 0.36412847564239 no 2173 0.32575870101651 3368 94937 An inhibitor of serotonin biosynthesis.
SGTC_472 calcifediol 10 µM -0.452651962999016 0.363743630083083 no 2174 0.325399687515541 3243 5283731 A vitamin D metabolite.
SGTC_174 3553-0389 74.3 µM -0.45321956153871 0.363524545833876 no 2175 0.325195323983801 3322 738071
SGTC_1711 st032263 62.8 µM -0.454603943721301 0.362990383025886 no 2176 0.324697098523873 3243 3958979
SGTC_1137 ixabepilone 100 µM -0.455211105499954 0.362756194104997 no 2177 0.324478685843203 3265 154225 A novel microtubule stabilizer.
SGTC_3076 9116187 49.47 µM -0.455413042009447 0.36267831636043 no 2178 0.324406057135851 3275 27241210
SGTC_2801 7907800 81.82 µM -0.458356719323846 0.361543720088782 no 2179 0.323348090422586 3275 6620925
SGTC_1169 aniline yellow 25.8 µM -0.45965287310518 0.361044522154644 no 2180 0.322882700667086 3214 6051 A DNA damaging agent.
SGTC_2368 9071271 200 µM -0.460270309780273 0.360806807032543 no 2181 0.322661104726897 3231 27209959
SGTC_1476 4112-3294 3.34 µM -0.460775919707313 0.360612185606994 no 2182 0.322479689918986 3326 704369
SGTC_2999 9069765 71.4286 µM -0.461281288663452 0.360417693009802 no 2183 0.322298403801965 3245 2097066
SGTC_886 0866-0150 153 µM -0.462170136752465 0.360075705075778 no 2184 0.321979658465261 3359 271463
SGTC_3107 9121808 49.47 µM -0.462190236883212 0.360067972761861 no 2185 0.321972451971548 3301 662681
SGTC_1378 2093-0007 380 nM -0.463566308553773 0.359538748402058 no 2186 0.321479248721776 3304 3618014
SGTC_302 1094-0063 18.9 µM -0.463601879135987 0.359525071853234 no 2187 0.321466503896677 3187 5440289
SGTC_2278 7948257 134.34 µM -0.465900981769122 0.358641471252117 no 2188 0.320643189192373 3316 1247028
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.466188272842459 0.358531111410836 no 2189 0.320540371385008 3263 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1114 scopoletin 1.73284 µM -0.466406309471728 0.358447362819383 no 2190 0.320462348049415 3329 5280460 A coumarin with genotoxic properties.
SGTC_977 1348-1378 135 µM -0.46644398706856 0.358432891419395 no 2191 0.320448866110567 3194 X977
SGTC_739 1486-1183 203 µM -0.468507599535892 0.357640599835102 no 2192 0.319710818843276 3338 4346692
SGTC_3281 9140613 49.47 µM -0.468704974772204 0.35756485278305 no 2193 0.319640265278231 3262 16013766
SGTC_1229 0139-0193 12.2 µM -0.468727072630654 0.357556372597042 no 2194 0.319632366604901 3353 3090752
SGTC_1570 verbenone 133 µM -0.469597132694508 0.357222537751839 no 2195 0.319321436808675 3371 29025 A natural terpanoid with antifungal properties.
SGTC_529 4076-0302 30.3 µM -0.471135786571144 0.356632436584073 no 2196 0.318771885417015 3230 5816522
SGTC_3340 9146634 11.102 µM -0.471985647428778 0.356306646755696 no 2197 0.318468516586501 3315 4907387
SGTC_2830 7992007 71.43 µM -0.472482509233454 0.356116225867701 no 2198 0.318291211681999 3190 1952075
SGTC_155 k072-0202 43.6 µM -0.474295808398035 0.355421588794745 no 2199 0.317644490074005 3311 5857737
SGTC_80 0159-0065 512.242 µM -0.476558468874733 0.354555484122315 no 2200 0.316838281551684 3311 1548079
SGTC_949 1165-0505 146 µM -0.47683198339495 0.354450838633351 no 2201 0.316740884396185 3211 6244267
SGTC_1374 2889-5571 141 µM -0.4792576022802 0.353523288739522 no 2202 0.315877690064828 3265 2853281
SGTC_1873 rapamycin 2 nM -0.479302155845471 0.35350625969268 no 2203 0.31586184435097 3275 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_199 4063-0024 41.6 µM -0.479987724298682 0.353244262042753 no 2204 0.31561806094021 3338 306215
SGTC_770 0389-1121 67.2 µM -0.480078860553109 0.353209438538057 no 2205 0.315585659555051 3411 6753108
SGTC_319 1348-1596 45.5 µM -0.480647673431313 0.352992120789049 no 2206 0.315383463349311 3397 5380505
SGTC_2682 pyrogallin 40.03 µM -0.481111352229758 0.352815005497597 no 2207 0.315218680099179 3283 822798 An ATP competetive kinase inhibitor.
SGTC_2735 sertaconazole 140 nM -0.481256860611738 0.352759431009704 no 2208 0.315166976567662 3323 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1919 st067113 52.3 µM -0.482199594251347 0.35239944586069 no 2209 0.314832082529468 3347 1268243
SGTC_1406 3909-7906 11.9 µM -0.48242565510502 0.352313143605891 no 2210 0.314751799925598 3297 X1406
SGTC_1876 myriocin 605 nM -0.485683077480923 0.351070418009001 no 2211 0.313595941823237 3396 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_450 aminopyrene 156 nM -0.486821924814974 0.350636315806143 no 2212 0.313192265814566 3343 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2214 7179297 48.276 µM -0.486828185131183 0.350633930057027 no 2213 0.313190047399856 3303 769744
SGTC_1403 3909-7815 62.9 µM -0.486857200621646 0.350622872596538 no 2214 0.313179765516961 3239 6615483
SGTC_2133 5320837 200 µM -0.48835014807719 0.350054098936487 no 2215 0.3126509231907 3370 2841355
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.489734729311674 0.349526910400244 no 2216 0.312160811567443 3367 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1075 aripiprazole 15.2 µM -0.491881761387204 0.348709987595499 no 2217 0.31140146620901 3284 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1851 st056236 18.9 µM -0.491961185230869 0.348679781092304 no 2218 0.311373391567827 3413 5393171
SGTC_2725 haloperidol 53.21 µM -0.49220864605127 0.348585672860319 no 2219 0.311285926459591 3256 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2070 5230947 200 µM -0.493157722725266 0.348224829727145 no 2220 0.310950573808437 3393 2835538
SGTC_2757 clomiphene 4.22 µM -0.493256893107277 0.348187132631275 no 2221 0.310915541380554 3456 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.493430317457469 0.348121213385013 no 2222 0.310854282489941 3381 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1824 st053723 68.6 µM -0.493642793755958 0.348040456601782 no 2223 0.310779236378402 3312 675225
SGTC_2154 5570129 200 µM -0.494341840143131 0.347774815675179 no 2224 0.310532390455264 3362 673366
SGTC_363 0455-0021 3.06 µM -0.496979628402627 0.34677311746481 no 2225 0.309601708566809 3309 4597466
SGTC_3165 9101544 49.47 µM -0.497181347947739 0.346696558572499 no 2226 0.309530586667125 3358 5002184
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.497315308595521 0.346645719765154 no 2227 0.309483359013647 3429 688664
SGTC_1203 3992-3522 103 µM -0.498250303655229 0.346290960913231 no 2228 0.309153815361905 3550 5322312
SGTC_1224 0823-0416 294 µM -0.499206665526913 0.345928234463559 no 2229 0.308816899660188 3403 3598164
SGTC_390 dec-rvkr-cmk 16.7 µM -0.49983008247172 0.345691862578228 no 2230 0.308597363337092 3341 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_917 harmaline 728.087 nM -0.500092738354917 0.345592293190101 no 2231 0.308504889523771 3311 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1779 st039427 55 µM -0.500528595084644 0.345427089212574 no 2232 0.308351463324171 3439 1124498
SGTC_2711 st079103 59.1 µM -0.500831445317071 0.345312316387949 no 2233 0.308244876529837 3295 54693780
SGTC_546 peri-Naphthalide 147 µM -0.501259364771367 0.345150169639144 no 2234 0.308094299737958 3276 223824 A penicillin ester.
SGTC_1836 st055642 81 µM -0.502511121867614 0.344676018553417 no 2235 0.307654015488654 3274 8571
SGTC_2440 5628896 157.78 µM -0.503534695211159 0.34428848204333 no 2236 0.307294196724058 3275 5522048
SGTC_1070 indatraline 8.81 µM -0.504416223529415 0.343954856364381 no 2237 0.306984459913952 3299 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2717 st081029 62.2815 µM -0.504538295874301 0.343908666090519 no 2238 0.306941579006745 3378 5292846
SGTC_2248 tofa 1.1 µM -0.505285551850038 0.343625966866345 no 2239 0.306679144586775 3214 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_985 1493-0307 8.71 µM -0.506538912056589 0.343151996464109 no 2240 0.306239190130206 3419 3278274
SGTC_1561 5-methoxyflavone 52.9 µM -0.507887270484344 0.342642376946439 no 2241 0.305766201191584 3356 94525
SGTC_2222 6885208 172.143 µM -0.509140179167971 0.342169089737133 no 2242 0.305326985161376 3344 609514
SGTC_558 k064-0027 21.3 µM -0.509433708270377 0.342058244699786 no 2243 0.305224126928595 3351 5088526
SGTC_2094 5332512 191.667 µM -0.510476728707966 0.341664480322681 no 2244 0.304858757008294 3409 755774
SGTC_3118 9124250 49.47 µM -0.510616117005422 0.341611871048788 no 2245 0.304809944031927 3289 1504786
SGTC_2598 perillyl alcohol 100 µM -0.510732543763995 0.341567930498222 no 2246 0.304769174716563 3408 10819 An apoptosis inducer.
SGTC_2739 tacrine 100.86 µM -0.511665905993593 0.341215748482911 no 2247 0.304442425654001 3369 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_984 1492-0255 2.91 µM -0.512048960475258 0.341071251992505 no 2248 0.30430837206001 3357 1585198
SGTC_2385 9074692 200 µM -0.513010492588288 0.340708643858763 no 2249 0.303971990523368 3323 17046906
SGTC_2766 oltipraz 83.91 µM -0.513609411482484 0.340482856940661 no 2250 0.303762549101866 3397 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3318 9139014 38.6185 µM -0.515214034309407 0.339878210793941 no 2251 0.30320173151995 3342 16643984
SGTC_1249 0481-0015 10.2 µM -0.515428354951446 0.339797482668293 no 2252 0.303126861262152 3275 4227577
SGTC_114 0364-0001 490.298 µM -0.51572081200965 0.339687334763604 no 2253 0.303024708359653 3366 4003655
SGTC_3136 9095672 49.47 µM -0.516647568703476 0.339338381472803 no 2254 0.302701101479494 3306 17217380
SGTC_3292 9120825 59.784 µM -0.51820707049454 0.338751490583852 no 2255 0.302156901079376 3456 24824900
SGTC_1835 st008666 49.2 µM -0.518214275573376 0.338748779986972 no 2256 0.302154387830002 3263 690455
SGTC_2262 9014885 67.46 µM -0.518699699897287 0.338566179482847 no 2257 0.301985085502193 3335 6457424
SGTC_1259 0671-0132 43 µM -0.519406756419755 0.33830027620363 no 2258 0.301738560372486 3267 X1259
SGTC_462 ag-879 158 µM -0.520725035118346 0.337804725506109 no 2259 0.301279165883353 3402 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2492 derrusnin 100 µM -0.522939450069845 0.336972943398699 no 2260 0.300508195167545 3345 1715307 Part of coumarin class of compounds.
SGTC_1820 st053765 18.6 µM -0.523364298715678 0.336813452014693 no 2261 0.300360381792662 3385 3690829
SGTC_1885 st057546 99.9 µM -0.523431230609513 0.336788327951902 no 2262 0.300337097838771 3468 702008
SGTC_66 0109-0187 42.4 µM -0.523494740321466 0.336764489138644 no 2263 0.300315005131719 3434 759417
SGTC_1276 0871-0068 94.2 µM -0.524406424943045 0.336422354279447 no 2264 0.299997944362742 3354 3414906
SGTC_3189 9110682 49.47 µM -0.52476645050828 0.336287282009326 no 2265 0.299872778339619 3389 17122418
SGTC_2584 androsterone 48.74 µM -0.524845654648835 0.336257569501541 no 2266 0.299845245503106 3413 2754130 A steroid.
SGTC_1793 st048256 72.231 µM -0.527470370964182 0.335273517367117 no 2267 0.298933493313857 3374 672022
SGTC_1434 4073-0095 163 µM -0.528711992175305 0.334808404841776 no 2268 0.298502628447661 3427 24133745
SGTC_1001 4048-4355 44.4 µM -0.531249716647389 0.333858559294252 no 2269 0.297622872530487 3376 21824233
SGTC_1708 st033234 31.827 µM -0.531432697762141 0.33379011228233 no 2270 0.297559484016604 3467 674664
SGTC_1146 3579-1023 7 µM -0.531681357880747 0.333697105853297 no 2271 0.297473352791505 3427 X1146
SGTC_1982 st072467 71.9 µM -0.532234821561583 0.333490130332752 no 2272 0.297281684182551 3285 3163533
SGTC_2280 7785178 200 µM -0.535088110150379 0.33242390820134 no 2273 0.296294465633075 3337 2954328
SGTC_654 1124-0271 80.9 µM -0.536172829754852 0.332018923067558 no 2274 0.295919554794019 3350 5403748
SGTC_2118 5526350 200 µM -0.536336143711874 0.331957966016476 no 2275 0.295863127583755 3387 743594
SGTC_2859 9028643 45.46 µM -0.537882162792075 0.33138113381457 no 2276 0.295329201801153 3381 17151580
SGTC_3215 9129942 49.47 µM -0.53850403965844 0.331149219203012 no 2277 0.295114558484676 3406 17682944
SGTC_2333 9017922 200 µM -0.538904135704779 0.331000046852334 no 2278 0.294976501704767 3439 3163164
SGTC_3283 9109332 35.8195 µM -0.539190096575442 0.330893445250839 no 2279 0.294877846543186 3311 17027281
SGTC_3313 9133968 57.047 µM -0.54423980202436 0.329013261956026 no 2280 0.293138232824896 3411 1494643
SGTC_322 k048-0136 19.3 µM -0.544471400135471 0.32892713302198 no 2281 0.293058561993021 3433 6823282
SGTC_201 4262-0159 12.803 µM -0.544843282788188 0.328788852725862 no 2282 0.292930653640984 3367 1341029
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.545524004231648 0.328535794990756 no 2283 0.292696587897096 3452 6708760
SGTC_3297 9117502 71.43 µM -0.545614548822451 0.328502141022624 no 2284 0.292665460729494 3427 7453720
SGTC_3025 9087895 49.47 µM -0.545814094632302 0.328427977966363 no 2285 0.292596866854945 3449 17173641
SGTC_1973 st070275 50.2 µM -0.546404821739742 0.328208468376767 no 2286 0.292393848204272 3391 17118334
SGTC_2110 5483698 200 µM -0.547075516353516 0.327959315377857 no 2287 0.292163426077683 3380 2848765 YHR062C RPP1
SGTC_1457 k015-0032 57.3 µM -0.547384671828717 0.327844494518068 no 2288 0.292057241871252 3429 4302660
SGTC_392 N-ethylmaleimide 8.33 µM -0.547455566479852 0.327818166419521 no 2289 0.292032894544443 3349 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2962 9082311 13.18 µM -0.548655069027312 0.327372837798627 no 2290 0.291621093094639 3327 16459453
SGTC_3011 9081274 71.4286 µM -0.549280554872102 0.327140716609579 no 2291 0.291406464873881 3376 6625322
SGTC_1552 6-methylflavone 10.6 µM -0.549559220338824 0.327037323862313 no 2292 0.291310867784243 3433 689013
SGTC_3134 9127454 49.47 µM -0.550042145367221 0.326858176495402 no 2293 0.291145233461159 3514 24262820
SGTC_2976 9009005 19.48 µM -0.550649473467527 0.326632936825434 no 2294 0.290936993645839 3477 2993148
SGTC_2684 capsaicin 100 µM -0.55220097281782 0.326057819529266 no 2295 0.290405333972025 3462 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_153 4077-0274 519.67 µM -0.553255597898079 0.325667121967525 no 2296 0.290044200447318 3574 3121976
SGTC_2141 5621638 7.665 µM -0.553430171792157 0.325602467586055 no 2297 0.289984441710347 3461 2856238
SGTC_715 0868-0130 184 µM -0.553870898209413 0.325439265529792 no 2298 0.289833601462178 3500 2876258
SGTC_1299 1079-1439 3.74 µM -0.555655734131122 0.324778678933554 no 2299 0.289223111424081 3362 323161
SGTC_874 0599-0792 117 µM -0.555835896963314 0.324712029334144 no 2300 0.289161521651614 3499 765305
SGTC_816 0325-0417 81.3 µM -0.556535101225716 0.324453418252514 no 2301 0.288922552799284 3439 68101
SGTC_2246 7293507 91.5585 µM -0.556880099962076 0.324325846520547 no 2302 0.288804675936792 3460 887656
SGTC_2583 asiatic acid 100 µM -0.557410272641313 0.324129842378458 no 2303 0.28862357422034 3494 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3153 9100258 49.47 µM -0.558470922306554 0.323737867912702 no 2304 0.288261427486984 3360 25236848
SGTC_502 l-744,832 89.3 µM -0.559008873075349 0.323539137102605 no 2305 0.28807783228038 3446 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3236 9132701 49.47 µM -0.559739173876537 0.323269428504282 no 2306 0.287828678995709 3424 24282524
SGTC_1594 piperine 70.1 µM -0.562194110672818 0.32236347311981 no 2307 0.286991886769945 3430 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_818 4072-2707 53.5 µM -0.562590622298805 0.322217245539842 no 2308 0.28685683958472 3397 882871
SGTC_1367 1812-0510 76.9 µM -0.563617159929947 0.321838801608312 no 2309 0.286507352944281 3413 1142582 YDR527W RBA50
SGTC_2377 9073351 62.6 µM -0.564386358197557 0.321555349594841 no 2310 0.286245610438171 3371 7337946 YHR072W ERG7
SGTC_842 0271-0008 11.1 µM -0.564706313266008 0.321437475708316 no 2311 0.286136769693461 3515 1221709
SGTC_2835 9006588 71.43 µM -0.565018165723745 0.321322604187138 no 2312 0.286030704178026 3511 2345538
SGTC_2031 5180455 200 µM -0.565365174808804 0.321194802735022 no 2313 0.285912703353418 3440 29949
SGTC_3095 9117207 49.47 µM -0.565734266204635 0.321058891731195 no 2314 0.285787218819119 3433 17015229
SGTC_650 1328-0195 38 µM -0.565857495124602 0.321013520322241 no 2315 0.285745329003197 3457 2780821
SGTC_2336 9001819 198.65 µM -0.566589639813364 0.320744008560359 no 2316 0.285496507684292 3563 2989602
SGTC_1458 k015-0034 6.33 µM -0.567028906753785 0.320582354144201 no 2317 0.28534727117201 3420 3598957
SGTC_1094 duloxetine 25.4 µM -0.567396926317347 0.320446945634251 no 2318 0.285222268849747 3424 60834 A selective serotonin reuptake inhibitor.
SGTC_2066 5222451 176 µM -0.567495436644165 0.320410703961364 no 2319 0.285188813046371 3458 2281147
SGTC_1671 st016596 74.5 µM -0.568224901293029 0.320142389276796 no 2320 0.284941132505684 3493 2829167
SGTC_2107 5363541 170.161 µM -0.568666630043259 0.319979956492729 no 2321 0.284791198959053 3459 244052
SGTC_354 2783-3500 4.88 µM -0.568742924329763 0.319951905001626 no 2322 0.284765306624588 3390 6740761
SGTC_3252 9135871 49.47 µM -0.568877563042441 0.319902404243217 no 2323 0.284719616421145 3496 17682838
SGTC_1244 0416-0015 52.5 µM -0.570603006441015 0.319268318398277 no 2324 0.284134390053237 3408 96201
SGTC_2784 7567673 72.73 µM -0.570886414952078 0.319164218632586 no 2325 0.284038320152333 3510 3471247
SGTC_821 1114-0266 29.2 µM -0.57131642541062 0.319006297225414 no 2326 0.283892584762908 3456 3123235
SGTC_1500 4488-1866 171 µM -0.571686424319493 0.318870441358501 no 2327 0.28376721661647 3547 2900003
SGTC_132 0417-1715 25.805 µM -0.571965172598466 0.318768106886718 no 2328 0.283672784782422 3533 6769098
SGTC_1753 st043925 64 µM -0.573601204018425 0.318167763417843 no 2329 0.283118848412848 3457 670181
SGTC_2736 butenafine 14.65 µM -0.575099020604894 0.3176185565183 no 2330 0.282612165142003 3428 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2406 ethylparaben 405.7 µM -0.576626943446474 0.317058723762312 no 2331 0.282095747001648 3234 8434 A possible steroid mimic.
SGTC_2811 7967822 32.47 µM -0.578743455924508 0.316283922543614 no 2332 0.281381144673893 3486 2232244
SGTC_457 grayanotoxin iii 135 µM -0.578747065314674 0.316282601925357 no 2333 0.281379926774876 3470 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1027 k015-0025 8.67 µM -0.580171583492489 0.315761576562695 no 2334 0.280899457265189 3470 3598955
SGTC_2075 5212009 200 µM -0.581015447457273 0.315453101176317 no 2335 0.28061502124748 3461 780898
SGTC_1008 4106-0037 6 µM -0.583301471215626 0.314618089116949 no 2336 0.279845186156588 3482 2905394
SGTC_1456 k015-0012 13 µM -0.583574221607825 0.31451852520738 no 2337 0.27975340393015 3568 2989616
SGTC_3162 9099653 49.47 µM -0.584746926220831 0.314090598693918 no 2338 0.279358947916094 3471 25237511
SGTC_427 1354-0053 47.3 µM -0.584766639043292 0.314083407507621 no 2339 0.279352319535436 3569 6813657
SGTC_2088 5278280 127.392 µM -0.585668014011909 0.31375466371105 no 2340 0.279049316408517 3528 791502
SGTC_844 0330-0132 15.3 µM -0.589488489225497 0.312362927544609 no 2341 0.277766815785235 3524 2828079
SGTC_178 4092-0806 87.505 µM -0.589942063265704 0.312197875098898 no 2342 0.277614746243463 3503 2169044
SGTC_1783 st039459 87.517 µM -0.590349925441541 0.31204948906154 no 2343 0.277478037236791 3554 729761
SGTC_316 k060-0003 58.6 µM -0.590814948583085 0.311880344256765 no 2344 0.277322208926738 3525 6152314
SGTC_1399 3562-5772 25 µM -0.590962203914905 0.311826790729109 no 2345 0.277272872887026 3475 23847490
SGTC_3334 9142812 21.919 µM -0.591511671935672 0.311626996413326 no 2346 0.277088818466904 3514 45283678
SGTC_2703 st077852 53.4 µM -0.592274167451177 0.311349834158684 no 2347 0.276833505665898 3511 6281836
SGTC_477 mead ethanolamide 10 µM -0.59487728927368 0.310404422154172 no 2348 0.275962749564757 3410 16061185
SGTC_2794 7785382 27.27 µM -0.595250989630367 0.310268802755717 no 2349 0.275837855600798 3513 2205081
SGTC_403 arphamenine a 50 µM -0.595381921448036 0.310221292460788 no 2350 0.275794103600314 3477 5487158 An arginine aminopeptidase inhibitor.
SGTC_1047 2043-3044 82 µM -0.5956497898202 0.310124102844041 no 2351 0.275704603691277 3462 669592
SGTC_2876 9059903 25.97 µM -0.596101169170656 0.309960360674971 no 2352 0.275553821585652 3507 6916095
SGTC_505 gw-5074 63.9 µM -0.596244537498591 0.309908360329702 no 2353 0.275505938253633 3497 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_435 c-PAF 6.7 µM -0.597552994239601 0.309433952943269 no 2354 0.27506911833967 3464 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1147 3809-1045 12.3 µM -0.599035027942832 0.308896995100267 no 2355 0.274574763235401 3459 325925
SGTC_1341 1486-1360 280 µM -0.599216566547036 0.308831249616539 no 2356 0.274514238391007 3471 3976547
SGTC_1448 4255-0083 152 µM -0.600041599340807 0.308532535382379 no 2357 0.274239255999249 3564 5399660
SGTC_219 mitoxanthrone 164.414 µM -0.600212473774902 0.308470683821758 no 2358 0.274182320774186 3474 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_451 chloral hydrate 100 µM -0.600499111199678 0.308366941641947 no 2359 0.274086826526253 3551 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1365 1672-3266 55.4 µM -0.604242540951895 0.307013495944563 no 2360 0.272841200761466 3532 6415873
SGTC_1512 0259-0544 12.2 µM -0.605125873261741 0.30669450729364 no 2361 0.272547682040445 3517 18476
SGTC_1371 2421-0008 32.7 µM -0.606002739994566 0.306377998229134 no 2362 0.272256466871946 3494 2827552
SGTC_2227 7312221 64.1025 µM -0.606093442518776 0.30634526697504 no 2363 0.272226352591004 3535 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1298 1079-1278 263 µM -0.608301331651745 0.305548996919884 no 2364 0.271493818998624 3534 2840950
SGTC_3160 9100216 49.47 µM -0.608504427926086 0.305475796816022 no 2365 0.271426485049231 3488 17191039
SGTC_3209 9113616 49.47 µM -0.609786345369096 0.305013946744579 no 2366 0.271001673944327 3577 16649353
SGTC_1936 st074407 74.3 µM -0.612256721477496 0.304124793888035 no 2367 0.270183959374611 3493 809813
SGTC_2502 avocadyne acetate 18.59 µM -0.612714246607147 0.303960245492955 no 2368 0.270032650384419 3525 3952079
SGTC_1699 st031318 29.054 µM -0.612733157608706 0.303953445027022 no 2369 0.270026397204352 3538 5340658
SGTC_1116 jasmonic acid 1.58368 µM -0.615023775154696 0.303130232844526 no 2370 0.269269509669308 3575 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2520 obtusaquinone 4.71 µM -0.615467133791374 0.302971011926726 no 2371 0.269123133913822 3606 5967872
SGTC_524 r073-0010 27.8 µM -0.615763786098828 0.302864497740109 no 2372 0.269025215850705 3500 2772106
SGTC_533 1222-0222 6.71 µM -0.61597240155167 0.302789603576982 no 2373 0.268956367427032 3579 3982874
SGTC_1778 st046819 58.9 µM -0.616014701933939 0.302774418504709 no 2374 0.268942408299999 3523 671715
SGTC_3267 9137951 49.47 µM -0.616324699238885 0.302663145488268 no 2375 0.268840120284242 3509 16643986
SGTC_1733 st037357 54.9 µM -0.617387874429296 0.302281659779732 no 2376 0.268489458994662 3515 1272339 YGL099W LSG1
SGTC_2895 9054447 58.44 µM -0.617514075529746 0.302236390962686 no 2377 0.268447850044881 3546 2697450
SGTC_223 busulfan 5 mM -0.61763252309021 0.302193906137922 no 2378 0.268408800414486 3519 2478 A DNA alkylator.
SGTC_1366 1683-0113 21.9 µM -0.617866809722756 0.302109879997522 no 2379 0.268331569530291 3535 708623
SGTC_3218 9131285 49.47 µM -0.619177861444274 0.301639869269607 no 2380 0.267899597251072 3591 17156417
SGTC_3307 9126885 69.2785 µM -0.61984523296414 0.301400743627714 no 2381 0.267679842739035 3511 24824909
SGTC_345 1362-0200 395 µM -0.623358223818182 0.300143414542965 no 2382 0.26652457218008 3491 1419823
SGTC_2893 9048488 25.97 µM -0.624022921344198 0.299905780801222 no 2383 0.266306265998629 3503 6467338
SGTC_1731 st035964 63 µM -0.626473473554888 0.299030428899283 no 2384 0.265502215295768 3466 6739575
SGTC_2873 9040596 71.43 µM -0.627405156089832 0.298697930978216 no 2385 0.265196844390225 3568 6463863
SGTC_570 0987-0065 62.6 µM -0.62843078869738 0.298332098733284 no 2386 0.264860886498618 3452 3104428
SGTC_2163 5671233 125 µM -0.629388187890708 0.297990788801935 no 2387 0.26454747459673 3635 701023
SGTC_1612 st002233 45.4 µM -0.629877919333207 0.297816269847762 no 2388 0.264387230263361 3587 1035021
SGTC_2982 9019404 25.97 µM -0.632811194579871 0.296771955472952 no 2389 0.263428472753407 3464 22333232
SGTC_983 1491-0821 12.2 µM -0.632878828123312 0.296747896138818 no 2390 0.263406387301054 3554 46495113
SGTC_2802 7925815 54.55 µM -0.633598509516222 0.296491938631885 no 2391 0.263171436895365 3562 1262923
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.635095049383926 0.295960012556249 no 2392 0.26268321282537 3518 6857784
SGTC_25 0118-0223 35.662 µM -0.636673366081383 0.295399495140344 no 2393 0.262168812801724 3604 5333628
SGTC_1420 4'-methoxyflavone 42 µM -0.638410533904468 0.294783129122134 no 2394 0.261603237808166 3579 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2985 9022375 71.43 µM -0.638582197840814 0.29472225309812 no 2395 0.261547382678498 3625 4939335
SGTC_1465 k213-0056 144 µM -0.639855283565308 0.294270968327283 no 2396 0.261133343723149 3512 24048857 YMR208W ERG12
SGTC_89 0302-0250 142.109 µM -0.639887713145727 0.294259476825253 no 2397 0.261122801223411 3637 4203518 YLR208W SEC13
SGTC_853 0419-0306 21 µM -0.642643710722307 0.293283640539733 no 2398 0.26022765670653 3507 762713
SGTC_2980 9014342 25.29 µM -0.643150773300366 0.293104264669604 no 2399 0.260063135833033 3594 2996599
SGTC_98 0074-0023 107.663 µM -0.643607473725715 0.292942748223294 no 2400 0.259915001315241 3561 3563821
SGTC_590 k048-0076 22.4 µM -0.645002206125889 0.292449743708675 no 2401 0.25946287802709 3595 6832814
SGTC_268 camptothecin 39.6153 µM -0.645874793939225 0.292141501069356 no 2402 0.259180222393488 3609 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_449 xestospongin c 11.1929 µM -0.646855761534203 0.291795153782167 no 2403 0.258862649672783 3559 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_852 0418-0143 439 µM -0.647234034412789 0.291661649239883 no 2404 0.258740243628589 3629 5369229
SGTC_2399 5884133 200 µM -0.64802569782518 0.291382338204634 no 2405 0.258484164742188 3603 722445
SGTC_1438 4092-1045 4 µM -0.651083060301916 0.290304827131033 no 2406 0.257496435431152 3586 1351342
SGTC_2916 7875993 68.79 µM -0.65144781928201 0.290176399248697 no 2407 0.257378725317961 3592 1299250
SGTC_2970 9090938 41.86 µM -0.651475915123017 0.290166508096569 no 2408 0.257369659765896 3616 17217104
SGTC_841 0251-0215 91.2 µM -0.651579398381779 0.290130078136273 no 2409 0.257336270743629 3611 3888614
SGTC_3055 9094636 49.47 µM -0.65221702789384 0.289905656110004 no 2410 0.257130588344044 3641 25236176
SGTC_1849 st056239 19.2 µM -0.652323431594977 0.289868213866909 no 2411 0.257096273652011 3506 5393181
SGTC_1888 azatryptophan 97.5 µM -0.65236958479746 0.289851973789168 no 2412 0.257081390202346 3561 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.652509297532573 0.289802815215446 no 2413 0.25703633847723 3575 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2678 equilin 100 µM -0.653288845377534 0.289528599515043 no 2414 0.256785041122245 3624 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2315 7733312 200 µM -0.653346908693665 0.289508179894235 no 2415 0.256766328778207 3571 726316
SGTC_829 1635-0120 117 µM -0.65536038711135 0.28880050152765 no 2416 0.256117874768447 3603 285054
SGTC_1030 k029-0042 36.7 µM -0.655364903755392 0.28879891497612 no 2417 0.256116421114111 3591 6080581
SGTC_2302 7771753 200 µM -0.655602995769284 0.288715286732416 no 2418 0.256039798743917 3579 2203047
SGTC_2119 5528445 120.635 µM -0.655863258545123 0.288623884203276 no 2419 0.255956055098259 3613 791935
SGTC_3145 9085516 49.47 µM -0.658140436220176 0.28782473674417 no 2420 0.255223947332864 3600 25236195
SGTC_1720 st037298 9.481 µM -0.659148024024649 0.287471470053397 no 2421 0.254900359762882 3593 597396
SGTC_1755 st041960 45.185 µM -0.659408654412465 0.287380124772307 no 2422 0.254816693086555 3618 2257073
SGTC_2311 7694451 200 µM -0.660400709170827 0.287032556817947 no 2423 0.254498358606255 3555 2163142
SGTC_2091 4-phenylthiadiazole 200 µM -0.660876318821366 0.286865996856055 no 2424 0.2543458170141 3610 270010
SGTC_50 0929-0078 56.389 µM -0.665433500375592 0.285272384430104 no 2425 0.252886631931662 3537 1377751
SGTC_1976 st070609 63.5 µM -0.66584373689727 0.285129134957676 no 2426 0.252755492915438 3571 682556
SGTC_2780 5215298 71.43 µM -0.665865968750493 0.285121372851554 no 2427 0.252748387151943 3622 2834131
SGTC_2795 7780010 54.55 µM -0.665995286466477 0.285076224414014 no 2428 0.252707056601074 3601 953673
SGTC_1222 0366-0074 1.18 µM -0.667923379964584 0.284403477528727 no 2429 0.252091251220133 3653 286520
SGTC_1848 st056003 16.4 µM -0.668390564017499 0.284240582761381 no 2430 0.251942158575353 3675 146492
SGTC_2628 lathosterol 100 µM -0.668915827577057 0.284057490484171 no 2431 0.251774586582476 3678 6710616
SGTC_1641 st009299 47.1 µM -0.66957578467539 0.28382752778748 no 2432 0.251564127487171 3586 4046054
SGTC_1188 1403-0014 4.57 µM -0.670063432733151 0.283657663623047 no 2433 0.251408677157107 3655 9614867
SGTC_2038 4100038 30.985 µM -0.670717430677677 0.28342993069139 no 2434 0.251200278263673 3625 3596803
SGTC_2243 6634756 200 µM -0.673498111293419 0.282462631362999 no 2435 0.250315224967576 3679 885676
SGTC_2828 7998861 71.43 µM -0.673954148013586 0.282304144160229 no 2436 0.25017023256484 3559 2988188
SGTC_3328 9140624 29.0385 µM -0.674490250562491 0.282117886278493 no 2437 0.249999840995304 3643 4904392
SGTC_128 0906-2981 13.371 µM -0.676584632321926 0.281390803714074 no 2438 0.249334766115219 3617 6740226
SGTC_541 4513-1321 94 µM -0.677496491714059 0.281074526739114 no 2439 0.249045497624743 3603 747515
SGTC_2815 7968870 71.43 µM -0.681943620719567 0.27953451315201 no 2440 0.247637300759914 3651 2977326 YHR190W ERG9
SGTC_2570 licareol 100 µM -0.684814026954652 0.278542689393139 no 2441 0.246730641392951 3635 443158
SGTC_1520 flindersine 88 µM -0.684826618708166 0.27853834228966 no 2442 0.246726668024758 3713 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1204 4049-0315 18.3 µM -0.685063927787036 0.278456421269468 no 2443 0.246651790792163 3677 588402
SGTC_2491 paeonol 100 µM -0.685776628451367 0.278210461808889 no 2444 0.246426988237214 3601 11092 Increases levels of cortical cytochrome oxidase.
SGTC_189 3970-0742 2.116 µM -0.685880892427442 0.278174488250175 no 2445 0.246394110135427 3667 2891807
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.686673016151952 0.27790126077806 no 2446 0.246144402438527 3664 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1841 st054148 70 µM -0.687476507171497 0.277624246275274 no 2447 0.245891250059269 3620 675442
SGTC_631 k072-0230 41.5 µM -0.687600303138751 0.277581577921327 no 2448 0.245852258635358 3667 5773147
SGTC_225 nsc-122657 1.016 µM -0.688455559721848 0.277286886977647 no 2449 0.245582973243189 3608 275685
SGTC_1905 st060207 84.5 µM -0.688549766814528 0.277254435927972 no 2450 0.245553320964349 3598 1948547
SGTC_1025 k007-0731 70 µM -0.691927663255371 0.27609209770266 no 2451 0.244491378614343 3651 6256118
SGTC_2441 5730946 39.09 µM -0.692520091958772 0.275888489125354 no 2452 0.244305386357165 3690 1774275
SGTC_1166 k206-0078 225 µM -0.692954135780352 0.275739361815661 no 2453 0.244169167258555 3670 5404595
SGTC_2044 5102272 200 µM -0.69329461276115 0.275622409620056 no 2454 0.244062341585252 3644 592666
SGTC_1106 tegaserod maleate 11.7 µM -0.694814793733002 0.275100532552969 no 2455 0.243585687939064 3692 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_333 3486-0131 40.1 µM -0.695591452853554 0.274834093977531 no 2456 0.243342360188018 3729 6744690
SGTC_2147 5545932 89.7195 µM -0.695851471933704 0.274744920964686 no 2457 0.243260925420415 3676 797404
SGTC_1924 st058459 75.1 µM -0.696235280112462 0.274613320807949 no 2458 0.243140748359097 3632 688683
SGTC_1981 st071826 47 µM -0.696817159785518 0.274413865213193 no 2459 0.242958612889066 3639 11838600
SGTC_44 0929-0055 61.211 µM -0.69720979680229 0.274279318265876 no 2460 0.242835754407984 3620 1379590
SGTC_761 k216-0224 480 µM -0.697751275006899 0.274093820595661 no 2461 0.2426663777929 3713 1340404
SGTC_2346 9031566 143.75 µM -0.69866224386442 0.273781884058975 no 2462 0.242381567357121 3651 4771086
SGTC_736 0958-0254 92.6 µM -0.700841148278438 0.273036490349094 no 2463 0.241701077705576 3724 6812352
SGTC_3000 9075062 71.4286 µM -0.703103773883457 0.272263522196208 no 2464 0.240995540235963 3662 17057871
SGTC_668 1682-0499 62.6 µM -0.703604619457624 0.272092568224667 no 2465 0.24083951687951 3713 682214
SGTC_7 0192-1582 4.227 µM -0.70413495826147 0.271911605501574 no 2466 0.240674365719482 3718 252616
SGTC_160 3453-0671 289.699 µM -0.704681307924775 0.271725242168244 no 2467 0.240504293148974 3685 5322268
SGTC_1525 8-methoxypsoralen 92.5 µM -0.706090742689213 0.27124476878585 no 2468 0.240065854132294 3713 4114 Related to psoralen; DNA damaging agent.
SGTC_1503 4585-0012 61.3 µM -0.706150812792536 0.271224300425969 no 2469 0.240047177549928 3689 2922052
SGTC_1978 st071761 42 µM -0.707735634496459 0.270684564653661 no 2470 0.239554721979575 3691 5147680
SGTC_1039 k821-0043 94 µM -0.707911768740615 0.270624612520329 no 2471 0.239500025424712 3650 15992768
SGTC_1690 st023502 41.2 µM -0.707964134909461 0.270606789533844 no 2472 0.239483765001281 3664 24207482
SGTC_2216 7189485 200 µM -0.708539564716529 0.270410978856949 no 2473 0.239305125758155 3681 731273
SGTC_626 0214-0009 33 µM -0.711749175201006 0.269320094214682 no 2474 0.23831005524186 3721 3437874
SGTC_313 3474-0040 5.03 µM -0.712152507407331 0.269183165631589 no 2475 0.238185171277767 3677 1043375 YIL048W NEO1
SGTC_3296 9122258 64.045 µM -0.712218842792317 0.269160648557484 no 2476 0.238164635251681 3719 4730474
SGTC_987 1497-1013 404 µM -0.712352415449152 0.269115311137563 no 2477 0.238123286938231 3679 1676435
SGTC_1769 st044406 64.4 µM -0.713318823768783 0.268787405657466 no 2478 0.237824245972424 3710 670903
SGTC_610 4215-0184 155 µM -0.713459649939222 0.26873963963855 no 2479 0.237780686566459 3725 5605015
SGTC_1364 1653-0028 37.6 µM -0.7147453873983 0.268303735030109 no 2480 0.237383193313491 3692 5718652
SGTC_2833 9001315 45.46 µM -0.715356592575748 0.268096642441101 no 2481 0.237194363678041 3696 2989378
SGTC_280 3448-3607 3.04 µM -0.71605044446543 0.267861644498124 no 2482 0.23698010068154 3685 626179
SGTC_2225 6654152 15.4 µM -0.716419889249929 0.267736561054598 no 2483 0.236866058732687 3643 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1345 1488-0192 31.4 µM -0.717025432449989 0.267531605113525 no 2484 0.236679202094968 3715 658348
SGTC_167 3672-0051 66.205 µM -0.717646055578636 0.267321627246074 no 2485 0.236487776308839 3652 3237971
SGTC_2497 7-hydroxyflavone 100 µM -0.717882837870219 0.267241537680064 no 2486 0.236414765340345 3682 5281894
SGTC_1968 st069590 43.6 µM -0.719603702473027 0.266659834125785 no 2487 0.235884515876399 3679 6384066
SGTC_2957 9076800 11.52 µM -0.721722180806601 0.26594460540512 no 2488 0.235232651074121 3669 16459615
SGTC_2158 5657123 3.6195 µM -0.722122755344316 0.265809475033008 no 2489 0.235109504500733 3698 2858827
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.72306739584937 0.26549094655261 no 2490 0.234819239568729 3734 4174840
SGTC_1654 st012436 41.8 µM -0.72317808488114 0.265453635393878 no 2491 0.23478524050551 3672 4323132
SGTC_934 2950-0684 338 µM -0.724036235016211 0.265164459672142 no 2492 0.234521744855855 3727 1121253
SGTC_1658 st012944 20 µM -0.725473969968577 0.264680336762478 no 2493 0.234080654099476 3650 24207260
SGTC_1757 st041620 31.8375 µM -0.726195431973462 0.264437571157904 no 2494 0.233859485973014 3755 5289815
SGTC_1312 1218-2183 165 µM -0.727116074148617 0.264127947840723 no 2495 0.23357742631511 3728 6744073
SGTC_1071 trifluoperazine 6.31 µM -0.728332208984227 0.263719229994162 no 2496 0.233205125129428 3797 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1788 fluconazole 20 µM -0.729027460769013 0.263485715210716 no 2497 0.232992432436719 3730 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1666 st014829 29 µM -0.729085342520608 0.263466279179505 no 2498 0.232974730005057 3738 3858230
SGTC_1325 1431-0015 227 µM -0.731896637724823 0.262523160104752 no 2499 0.232115829273261 3681 1103340
SGTC_1068 loratadine 26.9 µM -0.732108998230041 0.262451988740219 no 2500 0.232051021034935 3754 3957 A H1 histamine antagonist.
SGTC_1808 st050063 61.5 µM -0.733118056215001 0.26211394397679 no 2501 0.23174321413335 3704 4011993
SGTC_83 0170-0301 39.027 µM -0.733246189573192 0.262071033961084 no 2502 0.231704144128381 3676 3089716
SGTC_2191 5911152 200 µM -0.733631166673436 0.261942132339629 no 2503 0.231586780251276 3743 2875902
SGTC_1965 Pectolinarigenin 58.4 µM -0.73479084021709 0.261554036184489 no 2504 0.231233443221934 3730 5320438 An anti-inflammatory.
SGTC_1102 cgs 12066b 26.1 µM -0.734914415928206 0.261512697767007 no 2505 0.231195809094332 3735 6438352 A 5-HT1B full agonist.
SGTC_2650 prasterone 100 µM -0.736993405959039 0.260817739450874 no 2506 0.23056317968627 3695 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2143 5623677 140.463 µM -0.737405814905707 0.260679993686593 no 2507 0.230437800168861 3694 5375313
SGTC_856 0433-0016 11.3 µM -0.738710309744341 0.26024453533485 no 2508 0.230041462030831 3772 3911780
SGTC_2364 9055074 200 µM -0.741008755963086 0.259478195422521 no 2509 0.229344065667548 3756 6470630
SGTC_3059 1327-0034 3 µM -0.743806367112727 0.258547000812742 no 2510 0.228496813814274 3705 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_776 4476-4378 112 µM -0.743938643968189 0.258503014888574 no 2511 0.228456797571933 3799 2892008
SGTC_2210 7115885 190.385 µM -0.744137799514292 0.258436797154684 no 2512 0.228396556692243 3775 2927039
SGTC_559 1550-0661 158 µM -0.744150021609126 0.258432733685495 no 2513 0.22839286002469 3782 5830875
SGTC_1087 pterostilbene 9.05 µM -0.744304846088296 0.258381262191608 no 2514 0.228346035068508 3769 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2733 amorolfine 100 µM -0.744958918789517 0.258163873949923 no 2515 0.228148277545706 3774 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2391 6285546 200 µM -0.745988908896306 0.257821737765597 no 2516 0.227837057487329 3735 846083
SGTC_2635 hydroquinidine 100 µM -0.746060562024854 0.25779794519918 no 2517 0.227815415791176 3714 442912 An experimental heart treatment.
SGTC_226 1,3-diallylurea 8.28947 mM -0.746726344413399 0.257576925307678 no 2518 0.22761438205446 3702 74537 YKL182W FAS1
SGTC_2030 5175110 200 µM -0.747455971449679 0.257334823962106 no 2519 0.227394185109063 3789 2831986
SGTC_2791 5663188 71.43 µM -0.747908367736532 0.257184771411969 no 2520 0.22725771498952 3718 54690634
SGTC_2381 9035592 200 µM -0.747949142381726 0.257171249355141 no 2521 0.227245417154868 3760 4749657
SGTC_2172 5754775 163.918 µM -0.748756749626883 0.256903499520586 no 2522 0.227001916106833 3726 2263357
SGTC_1640 st009078 66.4 µM -0.74895228234733 0.256838695454667 no 2523 0.226942983315982 3744 690618
SGTC_2707 st078556 66.6 µM -0.749103439311121 0.256788604372001 no 2524 0.226897431117378 3735 17250899
SGTC_438 sphingosine 6.67 µM -0.752205731224034 0.255761677004186 no 2525 0.225963673790997 3713 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_811 0416-0114 265 µM -0.752780554538841 0.255571633456766 no 2526 0.225790896883415 3793 6612453
SGTC_3049 9092223 49.47 µM -0.75283802164468 0.255552638192295 no 2527 0.225773627878584 3735 8623917
SGTC_1397 3532-0190 20.1 µM -0.753029252180277 0.2554894338712 no 2528 0.225716168017943 3678 5322280
SGTC_3024 9090631 49.47 µM -0.75359105715416 0.255303796856108 no 2529 0.225547407925565 3694 25236383
SGTC_1653 st012112 65 µM -0.754450381161519 0.255019987199238 no 2530 0.225289414559087 3763 720429
SGTC_3316 9136639 10.545 µM -0.75539067046688 0.254709626289202 no 2531 0.225007304704494 3794 4903665
SGTC_185 k048-0037 25.491 µM -0.755979322474325 0.254515430873285 no 2532 0.224830796608773 3774 6827589
SGTC_1368 1852-0141 284 µM -0.75703622413641 0.254166955364055 no 2533 0.224514080319072 3746 2838987
SGTC_3082 9117008 49.47 µM -0.757075257714085 0.254154090231334 no 2534 0.224502388176851 3830 41448529
SGTC_2312 7706453 155.7 µM -0.758034552320987 0.253838022315293 no 2535 0.224215149078768 3803 976098
SGTC_1482 3346-2049 8.48 µM -0.759367809405906 0.25339908432698 no 2536 0.223816282146599 3788 3826804
SGTC_355 1311-2252 105 µM -0.759383012976268 0.253394081273797 no 2537 0.223811736062377 3775 5338538
SGTC_1387 3342-1166 1.8 µM -0.759846279473867 0.253241658628771 no 2538 0.22367323794468 3777 3418228
SGTC_823 0417-1665 178 µM -0.759893946767689 0.253225978005246 no 2539 0.223658990099627 3806 3429856
SGTC_1041 0206-0046 107 µM -0.760534570520514 0.253015288092017 no 2540 0.223467556518125 3802 50494
SGTC_2953 9074162 66.49 µM -0.761062376817004 0.25284177118645 no 2541 0.223309905529525 3704 16451992
SGTC_909 3448-9333 149 µM -0.761427901620961 0.252721641224471 no 2542 0.223200763667398 3716 3344074
SGTC_2911 7942208 15.64 µM -0.761550383300581 0.25268139426571 no 2543 0.223164198719487 3767 1243384
SGTC_1785 bathophenanthroline 24 µM -0.762916258983103 0.252232802142213 no 2544 0.222756669496125 3719 72812 An iron chelator.
SGTC_3205 9113483 49.47 µM -0.763887119191923 0.251914199774878 no 2545 0.22246725703473 3833 17018033
SGTC_833 3852-0053 558 µM -0.763914366588668 0.251905261197401 no 2546 0.222459137707652 3829 3123681
SGTC_3251 9135047 49.47 µM -0.764410989296249 0.251742372196636 no 2547 0.222311180993141 3770 17682963
SGTC_2231 micatex 6.853 µM -0.764614547941388 0.251675622366455 no 2548 0.222250551847704 3801 20737 An antifungal of unknown mechanism.
SGTC_1662 st014054 52 µM -0.764704685482414 0.251646067946588 no 2549 0.222223707748193 3785 2838777
SGTC_3331 9141060 1.957 µM -0.765131907790928 0.251506014651788 no 2550 0.222096500711414 3768 4906567 YPR165W RHO1
SGTC_1265 0819-1001 68.8 µM -0.767537898283564 0.250718045405637 no 2551 0.221380884704116 3761 3106768
SGTC_3037 9091026 49.47 µM -0.768585655074425 0.250375310925686 no 2552 0.221069661992691 3785 25236398 YIL048W NEO1
SGTC_1178 0988-0033 191 µM -0.769082762312932 0.250212787779444 no 2553 0.220922090284212 3817 5392207
SGTC_2730 imipramine 71.33 µM -0.769464807538809 0.250087920785692 no 2554 0.220808714323725 3782 3696 A tricyclic antidepressant.
SGTC_216 k038-0035 28.382 µM -0.769576931089373 0.250051280796027 no 2555 0.220775446799396 3698 4444231 YPR107C YTH1
SGTC_2240 6690706 185.951 µM -0.769670170769389 0.250020813889749 no 2556 0.220747784384084 3691 805876
SGTC_875 0709-0210 25.7 µM -0.76979953688578 0.249978545607098 no 2557 0.220709407239472 3771 6251364
SGTC_2233 sulbentine 40.3845 µM -0.770329364548513 0.249805472578106 no 2558 0.220552270933134 3754 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1272 0839-0021 27 µM -0.772130947121553 0.249217445499697 no 2559 0.220018437322296 3817 5027250
SGTC_1776 st049249 45.9 µM -0.773279736852076 0.248842871263717 no 2560 0.219678422595487 3839 1822314
SGTC_2074 5212007 75.395 µM -0.773431767179497 0.248793322739428 no 2561 0.219633447813595 3670 758611
SGTC_2572 astragaloside iv 100 µM -0.773851279907312 0.248656625712265 no 2562 0.219509371758359 3843 45006101 An anti-inflammatory agent.
SGTC_938 3126-1755 342 µM -0.774532416932613 0.248434764384631 no 2563 0.219308002878802 3816 1777771
SGTC_1413 3910-0535 34.4 µM -0.774973972296969 0.248290996462034 no 2564 0.219177519791385 3806 2876951
SGTC_819 1013-0258 27.7 µM -0.775004938439006 0.248280915726522 no 2565 0.219168370727613 3813 5753198
SGTC_1358 1509-0022 2.48 µM -0.775763808450006 0.248033940966662 no 2566 0.218944228343527 3826 3258434
SGTC_881 0833-0569 170 µM -0.776237438380156 0.247879864243647 no 2567 0.218804402278437 3805 5418700
SGTC_519 k048-0011 62.8 µM -0.778093374729847 0.247276601559799 no 2568 0.218256984105993 3878 6836379
SGTC_1749 st037932 54.2 µM -0.778294189477231 0.247211374839784 no 2569 0.218197800089537 3831 594497
SGTC_3338 9144300 39.5675 µM -0.778297509808851 0.247210296438842 no 2570 0.21819682160088 3827 4901274
SGTC_2012 4023501 200 µM -0.778467233551793 0.24715517570423 no 2571 0.218146808050227 3823 3477460
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.782853600642804 0.245732909704654 no 2572 0.216856543657664 3818 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_152 4469-0003 551.229 µM -0.783040666909361 0.245672351898712 no 2573 0.216801615765154 3743 697280
SGTC_2607 solasodine 47.35 µM -0.785861887366873 0.244760028256105 no 2574 0.215974202494573 3837 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1158 4092-0494 91.8 µM -0.786650444842108 0.24450535180798 no 2575 0.215743260315269 3931 1148199
SGTC_2361 9034121 116 µM -0.78702134479667 0.244385613494649 no 2576 0.215634685609997 3806 6496917
SGTC_2575 plumbagin 510 nM -0.787630371615465 0.244189068811591 no 2577 0.215456472022343 3755 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1445 4239-0156 97.7 µM -0.790877215600112 0.243142689574097 no 2578 0.214507822661388 3924 4008346
SGTC_3250 9135583 49.47 µM -0.791873439878099 0.242822117350317 no 2579 0.214217237581436 3855 7699353
SGTC_2433 5607874 27.82 µM -0.791960622169422 0.242794074093127 no 2580 0.214191818594707 3820 2252428
SGTC_389 tpck 16.7 µM -0.792188242598375 0.242720865443274 no 2581 0.214125461547408 3844 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2595 hexamethylquercetagetin 100 µM -0.792782447634352 0.242529809975431 no 2582 0.213952292306331 3792 386331
SGTC_3034 9090421 49.47 µM -0.794169851284002 0.242084033679991 no 2583 0.213548278666753 3727 17173761
SGTC_696 1560-0013 611 µM -0.794469245734959 0.241987895802962 no 2584 0.213461152990512 3846 1650269
SGTC_86 0417-1630 471.922 µM -0.794584486735391 0.241950896545312 no 2585 0.213427622654305 3845 3634867
SGTC_901 1112-0062 60.1 µM -0.79750996069847 0.241012672842929 no 2586 0.212577460135183 3823 1908457
SGTC_2285 7945142 200 µM -0.797688209704108 0.240955570929052 no 2587 0.212525723776516 3868 2970608
SGTC_2880 9042983 58.44 µM -0.797897067371933 0.240888672920004 no 2588 0.212465112683836 3858 6464714
SGTC_1677 st019204 53.9 µM -0.798756945729737 0.240613356643294 no 2589 0.212215679922368 3865 3945625
SGTC_727 3032-0951 202 µM -0.800347991775911 0.240104386767599 no 2590 0.211754602338676 3830 3652836
SGTC_619 1652-1634 108 µM -0.805220099682537 0.23854947379199 no 2591 0.210346339829417 3803 5400454
SGTC_928 2764-0428 58.7 µM -0.805345032472411 0.238509674624015 no 2592 0.210310300984844 3884 662578
SGTC_6 0844-0013 19.835 µM -0.806584396367614 0.238115054082701 no 2593 0.209952983241554 3948 1584900
SGTC_1800 st050079 29.0735 µM -0.807024929697203 0.23797487199656 no 2594 0.209826060230886 3761 3645560
SGTC_694 1315-0438 43.2 µM -0.808070652117237 0.237642293960199 no 2595 0.209524955553336 3806 6793154
SGTC_149 3970-0822 46.1 µM -0.808547387890468 0.237490759196441 no 2596 0.209387768941319 3851 3114250 YBL034C STU1
SGTC_2842 9000675 19.48 µM -0.811356435006868 0.2365989561379 no 2597 0.208580504818381 3876 2989072
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.812531470442685 0.236226458697288 no 2598 0.208243368100112 3875 688664
SGTC_3090 9117696 49.47 µM -0.815095416587447 0.235414785721415 no 2599 0.207508847510544 3804 7923821
SGTC_2257 7960413 200 µM -0.815120827708793 0.235406748988133 no 2600 0.207501575391203 3837 2974689 YIL048W NEO1
SGTC_1567 st069303 68.4 µM -0.815217192091988 0.235376273360144 no 2601 0.207473999334823 3936 5581319
SGTC_1120 ficusin 1.78878 µM -0.815403016463552 0.235317511796084 no 2602 0.207420829130413 3955 6199 A DNA cross-linker.
SGTC_1130 3454-2858 15.9 µM -0.815872116845918 0.235169208447867 no 2603 0.207286640577244 3900 715628 YIL048W NEO1
SGTC_612 0302-0167 22.4 µM -0.8164120385985 0.234998579249115 no 2604 0.207132256772017 3865 235821
SGTC_923 1900-2434 73.3 µM -0.81762316419771 0.234616081243611 no 2605 0.206786198208506 3827 5910570
SGTC_2324 6149169 200 µM -0.82214203965128 0.233191972286583 no 2606 0.205498030771566 3792 2888231
SGTC_1013 4112-3890 241 µM -0.823005868288921 0.23292028682469 no 2607 0.205252328158432 3828 705171
SGTC_1409 3909-8004 61.9 µM -0.824571821381192 0.232428222570167 no 2608 0.204807362402709 3876 2119279
SGTC_2719 novobiocin 32.65 µM -0.825855858915262 0.232025175491974 no 2609 0.204442931407541 3850 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_961 1252-1571 372 µM -0.826840942008401 0.231716231308633 no 2610 0.204163610420799 3853 6813498
SGTC_851 0394-0702 453 µM -0.827477121287119 0.231516833073046 no 2611 0.203983342203475 3831 762646
SGTC_1633 st005664 67.9 µM -0.830442539155344 0.230588642778171 no 2612 0.203144311427733 3897 2063822
SGTC_3217 9129673 49.47 µM -0.830925646113096 0.230437625165227 no 2613 0.203007817311844 3863 17248312
SGTC_760 0568-0725 82.9 µM -0.831197363553186 0.2303527115053 no 2614 0.202931071980395 3918 3916171
SGTC_3147 9097027 49.47 µM -0.831676615190147 0.230202984563367 no 2615 0.202795751820193 3901 25236841
SGTC_2060 5238662 140 µM -0.832118752797705 0.230064901010466 no 2616 0.202670958897029 3869 790130
SGTC_1742 st038235 28.8875 µM -0.832573270953684 0.229922999224687 no 2617 0.202542719426137 3922 564103 YBR002C RER2
SGTC_621 3584-0052 32.1 µM -0.833756044744157 0.229553963800707 no 2618 0.202209234587063 3856 2273927
SGTC_2951 9072950 58.06 µM -0.833993872522011 0.229479799617019 no 2619 0.202142218376956 3883 16488155
SGTC_2988 9073640 71.4286 µM -0.836512105098768 0.228695338596413 no 2620 0.201433434830873 3928 9102229
SGTC_2902 5787006 60.46 µM -0.836931559468429 0.228564819747671 no 2621 0.201315519775075 3842 591003
SGTC_2331 7980721 200 µM -0.837531831214227 0.228378109950031 no 2622 0.201146846178058 3857 2981221
SGTC_2600 tangeritin 87.95 µM -0.839113461026685 0.227886567112951 no 2623 0.200702821506459 3842 68077 A bioactive flavone.
SGTC_2907 7721985 69.9 µM -0.839187253665927 0.22786364819668 no 2624 0.200682119434436 3929 3267881
SGTC_663 1486-0733 13.9 µM -0.840147313955937 0.227565585718931 no 2625 0.200412897259915 3906 722445 YPR165W RHO1
SGTC_1556 plumbagin 1.48 µM -0.841447439055901 0.227162296146787 no 2626 0.200048659405093 3795 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2973 9094665 17.96 µM -0.841638857729744 0.227102953475463 no 2627 0.199995065943802 3966 25237061 YIL048W NEO1
SGTC_489 paxilline 115 µM -0.841652751330752 0.227098646590152 no 2628 0.199991176345019 3855 105008 A toxic potassium channel blocker.
SGTC_1455 4262-0120 131 µM -0.844086960797015 0.226344775726146 no 2629 0.199310406742601 4002 1529587
SGTC_3355 9151058 44.0485 µM -0.844662944804813 0.226166601404522 no 2630 0.199149527051011 3884 17015728
SGTC_3227 9130768 49.47 µM -0.844707181833721 0.226152920443918 no 2631 0.199137174319234 3919 17720899
SGTC_74 000s-0487 160.283 µM -0.845132895400748 0.226021286085368 no 2632 0.199018321814176 3812 677548
SGTC_3156 9099931 49.47 µM -0.845676867886815 0.22585314808204 no 2633 0.198866515505259 3922 18111053
SGTC_122 0236-0016 402.397 µM -0.846123615590654 0.225715114480098 no 2634 0.19874189391483 3918 6808838
SGTC_2488 5268135 45.7 µM -0.847055861030709 0.225427228266326 no 2635 0.198481992992158 3966 1270356 YLR208W SEC13
SGTC_718 1130-0073 349 µM -0.848317022507972 0.225038100692366 no 2636 0.198130719999139 3952 6740020
SGTC_3101 9120531 49.47 µM -0.848843794703246 0.224875679484042 no 2637 0.197984108636139 3905 24824904
SGTC_218 alverine citrate 93.75 µM -0.849363123101992 0.224715618517941 no 2638 0.197839633191814 3927 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_420 mitomycin C 81.9 mM -0.849523701073294 0.224666140245497 no 2639 0.197794973826337 3883 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1092 toremifene 6.32 µM -0.84969902444722 0.224612125585911 no 2640 0.197746220479297 3895 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1478 0453-0656 35.7 µM -0.852271953342573 0.223820290280189 no 2641 0.197031584411845 3914 5258496
SGTC_2526 patulin 37.61 µM -0.855052589067064 0.222966318613485 no 2642 0.196261017416715 3974 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2639 lactacystin 53 µM -0.85790292552515 0.222092870323361 no 2643 0.195473034331637 3943 3870 A proteasome inhibitor.
SGTC_1226 3909-7979 35.4 µM -0.858786639304453 0.221822464972359 no 2644 0.195229120062728 3936 6615510
SGTC_2247 cerulenin 830 nM -0.860701655312771 0.221237139810512 no 2645 0.194701190596266 3932 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_415 dibenzyl ketone 100 µM -0.862923913593663 0.22055901474511 no 2646 0.19408965083373 3937 7593
SGTC_2412 st077135 33.4 µM -0.863052051437843 0.220519949660844 no 2647 0.194054424499664 4028 13258915
SGTC_2272 7805186 180 µM -0.86483194250337 0.219977728625682 no 2648 0.193565518134662 3940 2956062 YPR165W RHO1
SGTC_3201 9113999 49.47 µM -0.865849535286931 0.219668076015141 no 2649 0.193286340221633 3966 16649224
SGTC_305 1682-2595 20.8 µM -0.868206829676795 0.218951715633 no 2650 0.192640558037875 3963 226033
SGTC_2625 euphol 100 µM -0.868853837073349 0.218755331236501 no 2651 0.19246354087044 3963 6708538 A triterpene alcohol.
SGTC_2306 7482397 179.52 µM -0.869809410078248 0.218465474250575 no 2652 0.192202284055899 3929 891448
SGTC_16 erodoxin 22.806 µM -0.870232236432253 0.21833728761389 no 2653 0.192086751202714 3930 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1490 4089-0339 670 nM -0.870391417310453 0.218289040589017 no 2654 0.192043267714579 3863 742542
SGTC_979 1426-2828 121 µM -0.870440766076007 0.218274084442363 no 2655 0.19202978832081 4038 747872
SGTC_373 0844-0104 25.9 µM -0.870703230268907 0.21819454925388 no 2656 0.191958107133768 3987 5375804
SGTC_2821 7996764 71.43 µM -0.871779323599357 0.217868632625455 no 2657 0.191664388215664 3960 2987135
SGTC_1422 4031-0024 15.5 µM -0.872562701172242 0.217631547576352 no 2658 0.191450739080077 3885 782427
SGTC_1883 5-benzylidenerhodanine 20 µM -0.873166929502841 0.217448782834932 no 2659 0.191286048716333 3935 1273210
SGTC_287 k060-0039 29.6 µM -0.876222099848634 0.216526023994527 no 2660 0.190454652265294 3978 5861974
SGTC_1283 0922-0125 16.4 µM -0.876655547431055 0.216395292771934 no 2661 0.190336879172482 3943 3360884
SGTC_940 3232-1287 54.8 µM -0.876770966209098 0.216360489258042 no 2662 0.190305525999876 3833 1585493 YIL048W NEO1
SGTC_2697 mebhydrolin 72.4 µM -0.877650273971973 0.216095448148948 no 2663 0.19006676878741 4012 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1939 st074455 53.6 µM -0.878222342323302 0.215923116214803 no 2664 0.189911534755318 3950 1644229
SGTC_47 0149-0135 24.25 µM -0.88002529596351 0.215380509202269 no 2665 0.189422803087827 3965 5239155
SGTC_1054 3429-0080 167 µM -0.88049699439072 0.215238680107603 no 2666 0.189295066341234 3979 1162877
SGTC_2614 arthonioic acid 13.39 µM -0.882010907202135 0.214783846939408 no 2667 0.188885454481935 3856 6710684
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.885068336388022 0.213866991252219 no 2668 0.188059887867292 3930 15053
SGTC_1860 st056228 74.6 µM -0.886970978283612 0.213297583035819 no 2669 0.187547262813583 3942 688679
SGTC_2249 haloperidol 116.36 µM -0.887494284056561 0.213141127189148 no 2670 0.187406421117253 3931 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1332 1480-0653 17.5 µM -0.888157867233501 0.212942828060255 no 2671 0.187227919421819 3954 5749438
SGTC_1479 0549-0158 134 µM -0.888440778113888 0.212858318304422 no 2672 0.187151849300753 3984 5440202
SGTC_586 0957-0265 8.15 µM -0.890204220943313 0.21233199274916 no 2673 0.18667811931174 3843 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2299 7976368 114.88 µM -0.890707037256344 0.21218205925543 no 2674 0.186543179239374 4006 2979718
SGTC_960 1222-0186 7.7 µM -0.890798502582007 0.212154792101821 no 2675 0.186518639319746 4015 3126296
SGTC_3069 9117009 49.47 µM -0.895106630386625 0.210872798404612 no 2676 0.185365044966361 3924 41904981
SGTC_1381 2324-0066 62.1 µM -0.895493365324514 0.210757938150831 no 2677 0.185261705437284 4020 10885928
SGTC_2506 ethyl hematommate 54.16 µM -0.895804775549653 0.210665476009975 no 2678 0.185178519448284 4047 3940691 An allergen.
SGTC_2283 7944793 200 µM -0.89627493306892 0.210525924629412 no 2679 0.185052971776581 4003 2970533
SGTC_1735 st034310 56.75 µM -0.896655612257169 0.210412971817934 no 2680 0.184951356542271 4059 871153
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.896724679096152 0.210392482539348 no 2681 0.184932924149846 3954 390807
SGTC_3278 9139605 49.47 µM -0.898533477332797 0.209856303948998 no 2682 0.184450602890414 4014 7958859
SGTC_1726 st035556 14.5795 µM -0.899526545463307 0.209562272522446 no 2683 0.184186131455031 4089 5919439
SGTC_1651 st011928 86.1 µM -0.900457122739349 0.209286963683072 no 2684 0.183938516749901 3987 720198
SGTC_3282 9108498 15.4605 µM -0.900678021952204 0.209221642510057 no 2685 0.183879768754166 3964 16459645
SGTC_396 dithiazanine 1.25 µM -0.90103300302802 0.209116697699185 no 2686 0.183785386259404 3964 10578 An antihelmenthic.
SGTC_925 2064-1272 59.6 µM -0.903200766403248 0.208476503984461 no 2687 0.18320967560071 3961 6815817
SGTC_836 0330-0104 1.35 µM -0.90474280191819 0.208021807364519 no 2688 0.182800830016107 3958 46494820
SGTC_2014 4013930 200 µM -0.906982458180764 0.2073624484959 no 2689 0.182208036843984 3913 64556
SGTC_3204 9114183 49.47 µM -0.907006547188159 0.207355363371463 no 2690 0.182201667493086 3984 17027248
SGTC_2040 5100729 123 µM -0.910823223733567 0.20623460089089 no 2691 0.181194261950285 3988 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2073 5212005 126 µM -0.912424005033613 0.205765604279693 no 2692 0.180772778824389 3782 691789
SGTC_2366 9070441 60.58 µM -0.912481290927665 0.205748832407012 no 2693 0.18075770694123 3996 6837235
SGTC_2685 mycophenolic acid 18.85 µM -0.912809920002968 0.205652633734801 no 2694 0.180671260058787 3953 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_662 k832-1615 104 µM -0.913632344951268 0.205412004612358 no 2695 0.180455032303689 4028 5878478
SGTC_2629 bisabolol 100 µM -0.915533784979226 0.204856312560614 no 2696 0.179955737286264 4027 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2969 9091408 28.7 µM -0.915866784360896 0.204759086222975 no 2697 0.179868385053838 3945 4286311
SGTC_1896 st058441 89 µM -0.920821922331089 0.203315572387682 no 2698 0.178571703768533 4005 688759
SGTC_1569 carminic acid 40.6 µM -0.925318010010204 0.202011057129298 no 2699 0.177400256606699 4093 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_292 k038-0015 474 µM -0.926710847822166 0.201607951427857 no 2700 0.177038341877187 4001 46368540
SGTC_1416 3966-0321 25.3 µM -0.931628167344332 0.200188672459246 no 2701 0.175764360535371 4032 582530 YLR208W SEC13
SGTC_1423 4048-0112 5.59 µM -0.932732853817643 0.199870656328022 no 2702 0.175478958725339 4046 X1423
SGTC_1884 5633444 25 µM -0.934151327124924 0.199462753373139 no 2703 0.175112919381526 4019 5724239
SGTC_1741 st038134 10.228 µM -0.935796051970575 0.198990416355937 no 2704 0.174689102306775 4092 1272587
SGTC_562 3772-2733 112 µM -0.938967577978064 0.198081513112548 no 2705 0.173873695430103 4039 2876874 YIL048W NEO1
SGTC_1281 0884-0031 11.8 µM -0.939397256026521 0.197958568091675 no 2706 0.173763410657383 4033 1548255
SGTC_3065 9113888 49.47 µM -0.939514685711268 0.197924975618047 no 2707 0.173733277913026 4092 16648368
SGTC_813 k007-0158 173 µM -0.939911221363769 0.197811566260364 no 2708 0.173631550460438 4010 6523916
SGTC_1348 1493-0373 93.8 µM -0.940387245999666 0.197675474890118 no 2709 0.173509480932457 4011 3010129
SGTC_2434 5670830 169.91 µM -0.94068181930398 0.197591287253473 no 2710 0.173433969297784 4062 1549830
SGTC_2759 disulfiram 3.38 µM -0.94286743301802 0.19696732658012 no 2711 0.172874357309712 3932 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2453 5731132 22.18 µM -0.943024109429852 0.196922643623581 no 2712 0.172834285595257 4063 1362040
SGTC_1211 1056-0033 32.3 µM -0.943667515997779 0.196739213171715 no 2713 0.172669789369433 4077 6741922
SGTC_157 1348-1695 65.819 µM -0.943673855899828 0.196737406227562 no 2714 0.17266816897823 3982 5380510
SGTC_2279 7948423 32.93 µM -0.945643708205285 0.196176462758424 no 2715 0.17216517148361 3944 1247112
SGTC_1199 1638-0010 4.46 µM -0.946604200082831 0.195903301130417 no 2716 0.1719202514607 4018 3111136
SGTC_620 0109-0052 432 µM -0.949976801542251 0.194945970615364 no 2717 0.171062020151714 4022 493037
SGTC_573 3702-0553 84.7 µM -0.95248574950028 0.194235641240668 no 2718 0.170425344862145 3976 1222756
SGTC_2807 7945238 51.95 µM -0.953138653906881 0.194051050765096 no 2719 0.17025991180131 4088 17148797
SGTC_672 1441-0018 53.7 µM -0.953194844473347 0.194035169449116 no 2720 0.170245679033091 4019 251141
SGTC_855 0428-0020 25 µM -0.953617233139202 0.193915813767951 no 2721 0.17013871465885 4061 6812414
SGTC_1475 4092-1048 11.7 µM -0.954147442295919 0.193766054264429 no 2722 0.170004507136982 4059 2881759
SGTC_2208 7283366 200 µM -0.954700972806985 0.193609782811886 no 2723 0.169864468893059 3997 898663
SGTC_2055 5235184 200 µM -0.955901416687802 0.193271140465038 no 2724 0.169561021596488 4112 2836034
SGTC_2839 9003951 25.97 µM -0.956223018275285 0.193180478857669 no 2725 0.169479786493377 4097 2990634
SGTC_1972 st070201 17.4 µM -0.959076214400281 0.192377281368671 no 2726 0.168760175961926 4030 2829099
SGTC_2671 danthron 100 µM -0.959508625347443 0.192255732675706 no 2727 0.168651288281579 4030 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1754 st042065 16.137 µM -0.960196072264909 0.192062591293204 no 2728 0.168478271634615 3871 1126236 YIL048W NEO1
SGTC_381 3461-2219 42.7 µM -0.961439138324039 0.191713647738062 no 2729 0.168165706630241 4055 2883159
SGTC_2016 5121758 140 µM -0.961617496313331 0.191663612378507 no 2730 0.16812088970693 3975 2795203
SGTC_545 4218-0007 221 µM -0.961639408708223 0.191657465773233 no 2731 0.16811538419764 4059 2840508
SGTC_3126 9127922 49.47 µM -0.961814618799073 0.191608322257569 no 2732 0.168071366674174 4108 45595682
SGTC_2708 st078559 56 µM -0.962147030124012 0.191515107626137 no 2733 0.167987876325056 3992 17250902
SGTC_766 1391-0721 126 µM -0.962393682255329 0.191445959507095 no 2734 0.167925943005448 4099 1020919 YIL115C NUP159
SGTC_808 0711-0032 135 µM -0.962583292311409 0.191392813349094 no 2735 0.167878342706129 3960 4252555
SGTC_1555 citronellol 128 µM -0.963281648945928 0.19119714764444 no 2736 0.167703100000252 4003 8842 A terpine precursor.
SGTC_1842 st055362 61.2 µM -0.963915445281074 0.191019676652766 no 2737 0.16754415979713 4003 676032
SGTC_2398 5228213 48.84 µM -0.965206730018218 0.190658413326518 no 2738 0.167220638372913 4073 80771 YMR134W ERG29
SGTC_2919 7978188 46.38 µM -0.96666109718 0.190252026883343 no 2739 0.166856740433239 4053 2980291
SGTC_1568 digitonin 820 nM -0.96894978506698 0.189613589008227 no 2740 0.166285121982725 4039 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1816 st051957 91.6 µM -0.969283617779776 0.189520575416315 no 2741 0.166201850355331 4033 674121
SGTC_393 acivicin 6.25 µM -0.969379291446148 0.189493923674822 no 2742 0.166177990369463 3901 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_927 2425-1185 123 µM -0.971582227584508 0.18888089147892 no 2743 0.165629213811382 3999 730375
SGTC_2954 9074818 52.69 µM -0.971796528649131 0.188821321152746 no 2744 0.165575891586933 4076 16648742
SGTC_2933 9026794 32.47 µM -0.97192513355656 0.188785577770339 no 2745 0.165543897544844 4021 17586027
SGTC_110 0850-0284 111.64 µM -0.973054685797928 0.188471818559371 no 2746 0.165263061862402 3858 3906265
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.974676527161003 0.18802187743102 no 2747 0.164860369952503 4023 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1215 3852-0577 11.2 µM -0.974901850065053 0.187959419477855 no 2748 0.164804474166762 4113 2884876
SGTC_1941 st076221 61.8 µM -0.97954723743196 0.186674605878018 no 2749 0.163654830217587 3988 2828568
SGTC_2288 7946289 167.31 µM -0.980848377118362 0.186315715825396 no 2750 0.163333758847681 4139 1246052
SGTC_2788 5282734 71.43 µM -0.98161920903894 0.186103301003565 no 2751 0.163143740252739 4165 743706
SGTC_1419 3993-2473 62.6 µM -0.983709559179204 0.185528028134828 no 2752 0.16262916918431 4134 704026
SGTC_3177 9107506 49.47 µM -0.984282109389166 0.185370652728266 no 2753 0.162488411761948 4031 8897194
SGTC_634 1611-4317 11.2 µM -0.986561076305325 0.184745060779431 no 2754 0.161928929896576 4075 2843522
SGTC_3091 9116372 49.47 µM -0.988202513861963 0.184295289076618 no 2755 0.161526738633149 4152 17169793
SGTC_2552 juarezic acid 87.02 µM -0.988732984962967 0.184150080040894 no 2756 0.16139689996023 4064 1549512
SGTC_190 3970-0790 3.722 µM -0.989569566470777 0.183921222328348 no 2757 0.161192275725089 3972 2832352
SGTC_294 k038-0071 157 µM -0.99158747490932 0.183369926602551 no 2758 0.160699400825588 4069 24152826
SGTC_1223 0764-0573 147 µM -0.992455578075064 0.18313307674991 no 2759 0.160487669386696 4074 1609797
SGTC_3168 9103419 49.47 µM -0.993095401633853 0.18295863202255 no 2760 0.160331732347814 4072 16649256
SGTC_1395 3486-0190 4.35 µM -0.994044083514562 0.182700169529602 no 2761 0.16010070303985 4060 6748079
SGTC_1066 ketoconazole 628 nM -0.994414675753744 0.182599265924275 no 2762 0.160010513107195 4145 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.995086606328981 0.18241640370712 no 2763 0.159847072106663 4128 688788
SGTC_1492 4158-0558 28.5 µM -0.995523572241456 0.182297547245837 no 2764 0.159740842745091 4067 3967268
SGTC_2341 7987486 176.74 µM -0.996532210299069 0.182023378521557 no 2765 0.159495812432341 4125 1258686
SGTC_1547 harmine 94.2 µM -0.998152107740703 0.181583596680302 no 2766 0.159102802889456 4053 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2941 9056145 11.23 µM -1.00024466776686 0.181016478122561 no 2767 0.158596058737108 3972 2119517
SGTC_1637 st007924 17.4 µM -1.00158449563923 0.180653945928923 no 2768 0.158272156122555 4014 683336
SGTC_2371 9071574 200 µM -1.00243952715462 0.180422828652926 no 2769 0.158065679796964 4105 45596039
SGTC_1360 1598-0022 39.8 µM -1.0030679669624 0.18025307804098 no 2770 0.157914034506177 4139 761525
SGTC_2295 7971645 200 µM -1.00502726075983 0.179724488319689 no 2771 0.157441861695683 4152 2978226 YKL099C UTP11
SGTC_2581 avocatin a 64 µM -1.00603783618819 0.179452230475884 no 2772 0.157198684885448 4065 6710728 A skin care supplement.
SGTC_2362 9071156 126 µM -1.00637863246981 0.179360475472446 no 2773 0.157116734103606 4131 653133
SGTC_1278 0874-0585 172 µM -1.00755658689806 0.179043553680178 no 2774 0.156833689566019 4155 766306
SGTC_1471 k673-0312 37 µM -1.00787858969807 0.17895698205548 no 2775 0.156756375621113 4040 24099884
SGTC_790 1575-0012 79.1 µM -1.00896854982694 0.178664137843175 no 2776 0.156494858745543 4160 378741 YLR208W SEC13
SGTC_515 4092-1064 102 µM -1.01095476223634 0.178131270174543 no 2777 0.156019040954501 4137 717353
SGTC_600 1495-0418 41.6 µM -1.01136227250382 0.178022065951154 no 2778 0.155921535646072 4086 5377768
SGTC_3244 9134489 49.47 µM -1.01160919691697 0.177955915918562 no 2779 0.155862473392009 4117 16584271
SGTC_2478 5763493 32.33 µM -1.01191690309622 0.1778735043977 no 2780 0.155788893292915 4034 1365576 YLR208W SEC13
SGTC_119 0121-0043 24.815 µM -1.01344975866268 0.177463325504343 no 2781 0.155422691194256 4106 1092378
SGTC_1251 0490-5699 265 µM -1.01705687317948 0.176500450850499 no 2782 0.154563187378255 4163 3883818
SGTC_1948 st076329 66.6 µM -1.01738751724864 0.176412355138125 no 2783 0.154484558939769 3966 24208413
SGTC_669 0108-0021 26.2 µM -1.0203983147585 0.175611448516172 no 2784 0.153769796403695 4011 17201
SGTC_69 0096-0274 206.684 µM -1.02211179981724 0.17515667230712 no 2785 0.153363994488239 4250 6741392
SGTC_639 0833-0042 114 µM -1.02282340270878 0.174968025453874 no 2786 0.153195675403964 4113 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2924 9010168 62.78 µM -1.02344486711702 0.174803379929532 no 2787 0.1530487774169 4199 2993929
SGTC_986 1493-0483 84 µM -1.02388447332903 0.174686973783072 no 2788 0.152944922370517 4066 40079
SGTC_3137 9097352 49.47 µM -1.02455641188567 0.174509141994093 no 2789 0.15278627013434 4139 44120435
SGTC_1522 st012842 45.6 µM -1.02535611864841 0.174297645639037 no 2790 0.152597592690791 3962 3491067 YOR116C RPO31
SGTC_1587 estradiol valerate 56.1 µM -1.02676305289457 0.173925952924461 no 2791 0.152266025440056 4167 13791 A steroid.
SGTC_24 0417-1663 219 µM -1.02846590287619 0.173476758059078 no 2792 0.151865360986793 4140 4329390
SGTC_1911 st060208 74.3 µM -1.02944940309294 0.173217657189299 no 2793 0.151634272106066 4171 688783
SGTC_862 0452-0056 10.2 µM -1.0309493240063 0.172822981252749 no 2794 0.151282292312438 4070 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1751 st044839 27.194 µM -1.03270049619351 0.172362919055389 no 2795 0.150872040635955 4145 5291326
SGTC_1247 0448-0043 5.84 µM -1.03300085680565 0.172284087868278 no 2796 0.150801748846409 4159 3089013 YGL099W LSG1
SGTC_1143 3454-2408 5.08 µM -1.03344988257202 0.172166281653907 no 2797 0.150696706411836 4104 X1143
SGTC_1540 guanosine 70.6 µM -1.03402537081096 0.172015371981736 no 2798 0.150562151347028 3990 6802 Guanosine is a purine nucleoside
SGTC_964 1287-0107 19.4 µM -1.03480711501441 0.171810511333394 no 2799 0.150379499736962 4138 51516812 YPR165W RHO1
SGTC_3339 9145883 14.936 µM -1.03513742967186 0.171723997289651 no 2800 0.150302367341074 4033 2030670
SGTC_2557 derrustone 83.84 µM -1.03688368581973 0.171267090820976 no 2801 0.149895033959533 4128 629853 An antioxidant.
SGTC_2487 5918373 44.05 µM -1.0384717276264 0.170852256463025 no 2802 0.14952524556646 4213 2876279
SGTC_978 1416-0512 87.4 µM -1.03998213342205 0.17045829957837 no 2803 0.149174100722083 4218 6814003
SGTC_2950 9072895 21.46 µM -1.04058948071961 0.170300050216171 no 2804 0.149033057699373 4098 17332245
SGTC_1270 0831-1170 17.3 µM -1.04108051549873 0.1701721758709 no 2805 0.148919090842207 4152 6764716
SGTC_609 0986-0026 86.3 µM -1.04190878673468 0.169956618506355 no 2806 0.148726984978134 4096 2848610
SGTC_749 1000-0129 128 µM -1.04260123990435 0.169776542156007 no 2807 0.14856650738553 4196 708470
SGTC_3078 9116413 49.47 µM -1.04293165308197 0.169690659484317 no 2808 0.14848997419875 4075 17177322
SGTC_1138 3761-0006 1.03 µM -1.04367681254699 0.169497076155109 no 2809 0.14831747064284 4166 12061087
SGTC_142 0335-0849 62.6745 µM -1.04476777627695 0.169213912810346 no 2810 0.148065155692091 4141 3889043 YPR107C YTH1
SGTC_1023 4482-3888 16 µM -1.04482382131415 0.169199374337027 no 2811 0.148052201519558 4159 3303168
SGTC_3020 9089140 49.47 µM -1.0496733588471 0.167944408070947 no 2812 0.14693415822025 4178 17217859
SGTC_1998 st075797 76.8 µM -1.05019116996458 0.167810763517894 no 2813 0.146815114225839 4134 24208315
SGTC_1142 3253-1408 9.78 µM -1.05097487517907 0.167608623259809 no 2814 0.14663506467895 4163 256655
SGTC_1295 1013-0063 9.78 µM -1.05109934591471 0.167576533093119 no 2815 0.146606482237438 4155 6826038
SGTC_2182 6325192 200 µM -1.05145244199602 0.167485521892438 no 2816 0.146525420490702 4095 736248
SGTC_552 k242-0005 476 µM -1.05156487990824 0.167456547488326 no 2817 0.146499613964518 4221 4088318
SGTC_347 4534-1311 26.2 µM -1.05156909162132 0.167455462224306 no 2818 0.146498647359785 4140 2862016
SGTC_3103 9120822 49.47 µM -1.05234212956528 0.167256344431673 no 2819 0.146321304609901 4176 17141819
SGTC_2289 7946404 165.07 µM -1.05359428815465 0.166934139508109 no 2820 0.146034352693821 4158 1246120 YPR165W RHO1
SGTC_1581 himbacine 57.9 µM -1.05377433124817 0.166887843836728 no 2821 0.145993124085778 4142 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2777 climbazole 1.536 µM -1.05389922835782 0.166855733082675 no 2822 0.145964528116797 4002 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_382 3229-0966 23.2 µM -1.05401572113537 0.166825786655291 no 2823 0.145937859764281 4180 5722370
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.05631725812866 0.166234848909659 no 2824 0.145411646925119 4204 23847180
SGTC_2621 lithochol-11-enic acid 100 µM -1.05693405675419 0.166076711003096 no 2825 0.14527084203522 4092 6708711
SGTC_2327 6189656 200 µM -1.05859104574231 0.165652365361098 no 2826 0.144893033311852 4224 5349088
SGTC_116 0155-0182 31.788 µM -1.06149732994131 0.164909777088593 no 2827 0.144231972849365 4062 771486
SGTC_2120 5538279 151.968 µM -1.06243093126027 0.164671689661618 no 2828 0.144020048989658 4120 2058197
SGTC_778 3456-2434 196 µM -1.06303514769943 0.164517720884858 no 2829 0.143883006202939 4114 5539063
SGTC_1428 4049-0204 61.7 µM -1.06312839113325 0.164493968544418 no 2830 0.143861865427014 4217 X1428
SGTC_1956 st077085 54 µM -1.06364061797198 0.164363526226567 no 2831 0.143745767302179 4207 24208685
SGTC_1554 st069299 38.7 µM -1.06364648434617 0.164362032699915 no 2832 0.143744438032841 4137 24207999
SGTC_714 4296-0578 26.1 µM -1.06383580036507 0.164313839250128 no 2833 0.14370154512326 4190 1589775
SGTC_2095 5432005 200 µM -1.06715069219854 0.163471464995003 no 2834 0.14295189704122 4166 783734
SGTC_2605 digitonin 300 nM -1.06786085642884 0.163291364803971 no 2835 0.142791640897373 4204 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1234 0326-0494 15.5 µM -1.06885229140273 0.163040149042127 no 2836 0.142568116191156 4243 1547813
SGTC_387 norethindrone acetate 66.7 µM -1.06912743369483 0.162970476389493 no 2837 0.142506125750277 4170 541197
SGTC_1048 3161-0300 24.5 µM -1.06986167694214 0.162784643085187 no 2838 0.142340787638184 4155 2165101
SGTC_2468 5987765 72.9 µM -1.07106100104282 0.16248139665406 no 2839 0.142071001068418 4203 26772094
SGTC_2892 9047358 58.44 µM -1.07114430835361 0.162460346248953 no 2840 0.142052274049774 4173 6466771
SGTC_45 0kpi-0036 14.9 µM -1.07138528096025 0.162399466375148 no 2841 0.141998114159717 4202 2795021
SGTC_3032 9089427 49.47 µM -1.07557407004156 0.161343573860596 no 2842 0.141058894632303 4178 17173707
SGTC_2551 apiole 73.87 µM -1.07652462637751 0.161104586315103 no 2843 0.14084634664131 4068 10659 A possible DNA adduct former.
SGTC_2914 7968218 45.32 µM -1.07856252826389 0.160592998744771 no 2844 0.140391396658657 4136 2977111
SGTC_1248 0469-0687 58.6 µM -1.07916073740992 0.160443028149397 no 2845 0.140258039531904 4147 4017482
SGTC_724 3910-0327 137 µM -1.07936240375459 0.16039249117476 no 2846 0.140213102003352 4232 2885483
SGTC_2545 solidagenone 89.61 µM -1.08006308236697 0.160216984101206 no 2847 0.140057045057505 4006 6708572 An anti ulcer agent
SGTC_3247 9135149 49.47 µM -1.08065228414005 0.160069497122039 no 2848 0.139925907897129 4194 8934436 YOR116C RPO31
SGTC_2658 polymyxin b sulfate 77.05 µM -1.08144369809842 0.159871532824171 no 2849 0.139749896234461 4208 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1105 epirubicin 18.1 µM -1.08161336141679 0.159829114094596 no 2850 0.139712182456917 4213 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3057 9095946 49.47 µM -1.08299178543015 0.159484757458067 no 2851 0.139406034606552 4219 24540043
SGTC_1473 k844-0725 134 µM -1.08353960790991 0.159348035908864 no 2852 0.139284490103425 4224 54682906
SGTC_699 0375-0592 111 µM -1.08476793191536 0.159041758779378 no 2853 0.139012225962503 4247 762578
SGTC_2430 5571206 200 µM -1.08583091679049 0.158777019747852 no 2854 0.138776902688078 4199 1731771
SGTC_728 3030-5151 22.5 µM -1.08583829676824 0.158775182756337 no 2855 0.138775269859729 4242 3125388
SGTC_1055 3448-0672 86 µM -1.08944228352177 0.157879758953371 no 2856 0.137979446852279 4186 748378
SGTC_3314 9135860 59.4275 µM -1.0898050462293 0.157789813269329 no 2857 0.137899515311781 4178 25252478
SGTC_2751 anetholtrithion 17.25 µM -1.09006575262327 0.15772519286352 no 2858 0.137842090485314 4182 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1077 5-fluorocytosine 377 nM -1.09162858355626 0.157338183782773 no 2859 0.137498193596592 4243 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_90 0870-0863 4.608 µM -1.09179725935933 0.15729645138088 no 2860 0.137461111975328 4215 1738164
SGTC_1369 1866-0067 208 µM -1.09217379037435 0.157203319380703 no 2861 0.137378360181165 4204 3531355
SGTC_1430 4049-0248 69.1 µM -1.09350191808886 0.156875106942576 no 2862 0.137086743650156 4199 22774488
SGTC_1302 1159-0335 255 µM -1.09391646171904 0.156772755592168 no 2863 0.136995809119799 4196 649284
SGTC_1689 st020265 53.493 µM -1.09799693340968 0.155767627691708 no 2864 0.136102914170472 4205 5758320 YPR016C TIF6
SGTC_2882 9058044 58.44 µM -1.10331823872611 0.154463247610922 no 2865 0.134944494423957 4230 18076804
SGTC_3320 9137005 35.139 µM -1.10464355167089 0.154139507869427 no 2866 0.134657035933271 4230 4908713
SGTC_3256 9138902 49.47 µM -1.10565282675078 0.153893269283467 no 2867 0.13443840767743 4284 17228773
SGTC_780 0109-0199 192 µM -1.10570093992502 0.153881537342952 no 2868 0.134427991534432 4276 610414
SGTC_3228 9131799 49.47 µM -1.10574891653692 0.153869839291271 no 2869 0.134417605507915 4196 17015818
SGTC_418 lividomycin a 100 µM -1.1067877646305 0.153616683162271 no 2870 0.134192849718555 4233 72394 An antibiotic.
SGTC_1045 1348-1485 165 µM -1.10700650566555 0.153563413489148 no 2871 0.134145557802398 4176 6810614
SGTC_2363 9053361 176 µM -1.1100586605321 0.152821403090386 no 2872 0.133486874763811 4273 6469797 YMR079W SEC14
SGTC_687 k029-0044 34.9 µM -1.11423037840767 0.151811067446736 no 2873 0.132590183053736 4280 5829338
SGTC_740 k014-0057 261 µM -1.11472891018411 0.15169062712251 no 2874 0.132483304159699 4207 4012779
SGTC_1240 0356-0016 42.1 µM -1.116502425895 0.151262678281467 no 2875 0.132103566185867 4175 4305613
SGTC_2443 5493264 126.67 µM -1.11693481812744 0.151158464040097 no 2876 0.132011098027618 4247 5340055
SGTC_1407 3909-7909 12.3 µM -1.11787149690079 0.15093287160307 no 2877 0.131810940045258 4206 4411780
SGTC_604 1000-0114 314 µM -1.11838683971599 0.150808850551286 no 2878 0.131700906267317 4220 1572745
SGTC_1857 st056007 79.3 µM -1.11874648879554 0.150722338552431 no 2879 0.131624153107646 4186 619834
SGTC_1844 rapamycin 4 nM -1.11982227938239 0.150463759164903 no 2880 0.131394751591776 4107 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1183 1254-0324 198 µM -1.12034559592124 0.150338080561968 no 2881 0.131283259465304 4292 5799357
SGTC_3305 9127027 53.8275 µM -1.12112380709709 0.150151316387299 no 2882 0.131117583103235 4143 41905295
SGTC_1915 st067105 30.6 µM -1.12191869595905 0.149960709438955 no 2883 0.130948505327016 4148 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1304 1165-0502 251 µM -1.12213391384569 0.149909129962153 no 2884 0.13090275308053 4202 767425
SGTC_1578 josamycin 24.2 µM -1.12248836763135 0.149824206769749 no 2885 0.130827425353155 4217 5282165 A P450 substrate.
SGTC_459 nigericin 15.3 µM -1.12374439197121 0.14952353564179 no 2886 0.130560739067261 4288 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1560 lithocholic acid 53.1 µM -1.12566225082505 0.149065209845566 no 2887 0.130154253920383 4125 9903 A bile acid which acts as a detergent.
SGTC_1951 sophoraflavanone G 9.2 µM -1.12699118054555 0.148748176055028 no 2888 0.129873104934652 4177 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1814 st052110 31.539 µM -1.12746773126741 0.14863459842728 no 2889 0.129772388145492 4158 674163
SGTC_1033 k072-0102 21.3 µM -1.12748876016269 0.148629587889524 no 2890 0.129767945032179 4185 5965931
SGTC_1879 gemcitabine 100 µM -1.12773781658584 0.148570254006661 no 2891 0.129715330883324 4192 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1194 1488-0194 225 µM -1.12822016011923 0.148455388079657 no 2892 0.129613475931996 4169 1391452
SGTC_1967 st070177 51.4 µM -1.12957986417473 0.148131906112301 no 2893 0.129326649800659 4267 5729214
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.13023783718582 0.14797553975407 no 2894 0.129188010114698 4263 5393153
SGTC_638 3970-0837 4.09 µM -1.13198046517281 0.14756194063855 no 2895 0.128821323659877 4203 4118451 YLR208W SEC13
SGTC_1123 mangostin 811.285 nM -1.13485958116414 0.146880303170491 no 2896 0.128217078705572 4225 5281650 An antioxidant.
SGTC_729 4092-0585 94.1 µM -1.13513756112885 0.146814602744385 no 2897 0.128158842943701 4227 2169061
SGTC_1202 1988-0068 29.6 µM -1.13718519890579 0.146331252104917 no 2898 0.127730436542456 4198 2850480
SGTC_217 ketoconazole 989 nM -1.13884828350235 0.145939463527805 no 2899 0.127383219593775 4053 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3073 9114972 49.47 µM -1.14030720108074 0.145596353405309 no 2900 0.127079169389629 4227 41905075
SGTC_1200 1643-0193 18.4 µM -1.14140699390005 0.145338061548194 no 2901 0.126850297796289 4257 5403974
SGTC_1141 3253-0389 52.6 µM -1.14141202728403 0.14533688014179 no 2902 0.126849250987645 4233 5402031
SGTC_346 4513-0042 7.16 µM -1.14270939027512 0.145032586123622 no 2903 0.126579634867036 4198 2827372
SGTC_1954 st077032 68.9 µM -1.14373532277065 0.144792259470499 no 2904 0.126366709858362 4197 698907
SGTC_704 1310-0270 142 µM -1.14549136207032 0.144381526582542 no 2905 0.126002835801918 4254 5718033
SGTC_1261 0712-0010 12.7 µM -1.14643915387485 0.144160167212369 no 2906 0.125806744935702 4254 2840123
SGTC_2126 5251174 33.877 µM -1.1467029141801 0.144098605991789 no 2907 0.12575221282825 4247 790722
SGTC_1424 4048-1941 275 µM -1.14767451001011 0.143871990059482 no 2908 0.125551478875351 4305 X1424
SGTC_1181 1222-0449 220 µM -1.1486030561021 0.143655639877548 no 2909 0.125359848159214 4301 658318
SGTC_2677 mitomycin C 100 µM -1.15004395917529 0.143320346018761 no 2910 0.125062883077437 4283 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3007 9078383 71.4286 µM -1.15087654489971 0.143126846890882 no 2911 0.124891514224321 4227 6496995
SGTC_2264 7948757 110.76 µM -1.15136649105803 0.143013062273204 no 2912 0.124790746652116 4204 2971411
SGTC_1163 k060-0048 49.9 µM -1.15152968030441 0.142975176934931 no 2913 0.124757196021209 4230 6809982
SGTC_2525 harmine 47.85 µM -1.15384140439429 0.142439225148766 no 2914 0.124282597871863 4227 5280953 A monoamine oxidase inhibitor
SGTC_1818 st052136 56.3 µM -1.15404345135362 0.142392447097685 no 2915 0.12424117761546 3934 674169
SGTC_3208 9114115 49.47 µM -1.15435135977104 0.142321179917005 no 2916 0.124178074001886 4266 650895
SGTC_2851 9015922 71.43 µM -1.15441091361067 0.142307398622692 no 2917 0.124165871459364 4270 2996893
SGTC_2886 9058944 51.95 µM -1.15604863439965 0.141928769095834 no 2918 0.123830632234784 4116 4949929
SGTC_2253 7938677 135.83 µM -1.15639782839987 0.141848126200779 no 2919 0.123759234722241 4301 2301972
SGTC_270 tamoxifen 5.46 µM -1.16032301638677 0.140943777601903 no 2920 0.122958658476174 4305 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2021 4019055 173 µM -1.16037340141819 0.140932194560069 no 2921 0.122948405668174 4093 44827708 YER133W GLC7
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.16066154466555 0.140865965560376 no 2922 0.122889783154891 4251 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_289 k017-0060 526 µM -1.16296305973081 0.140337726021634 no 2923 0.122422245196287 4231 5512909
SGTC_367 0335-0881 7.1 µM -1.16438188560053 0.140012750784275 no 2924 0.122134642603536 4212 23828853
SGTC_57 miconazole 162.5 nM -1.16475687693198 0.139926946326003 no 2925 0.122058709445287 4115 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_988 1497-1057 103 µM -1.16613924836211 0.139610944732463 no 2926 0.121779075157914 4239 3533044
SGTC_2871 9038510 12.99 µM -1.16635313477931 0.139562095000237 no 2927 0.121735849187088 4234 4945164
SGTC_2328 6201408 200 µM -1.16913152918723 0.138928590934458 no 2928 0.121175321299826 4261 2890418
SGTC_759 3486-0358 89.3 µM -1.17296607459037 0.138057493275874 no 2929 0.12040470528525 4256 875103
SGTC_2747 doxorubicin 7.63 µM -1.17442226393358 0.137727667190137 no 2930 0.120112965936491 4239 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_175 3793-3120 23.7 µM -1.17539425661683 0.137507810864253 no 2931 0.119918510105228 4259 5322297
SGTC_2171 5739187 198.077 µM -1.17667941656206 0.137217486817211 no 2932 0.119661743214522 4199 2262761
SGTC_838 0109-0203 71.4 µM -1.18008344481458 0.136450524128012 no 2933 0.118983514176037 4294 759422
SGTC_554 4483-2211 187 µM -1.18375481404314 0.13562661931386 no 2934 0.118255066911626 4332 747107
SGTC_1797 st048695 56.8 µM -1.18405477879819 0.135559454096942 no 2935 0.118195689660853 4239 592262 YIL048W NEO1
SGTC_680 0417-1641 114 µM -1.18573441742092 0.135183786702917 no 2936 0.117863599050739 4276 2835990
SGTC_2653 dihydrofissinolide 100 µM -1.18654581037543 0.135002566763973 no 2937 0.1177034107888 4312 6857746
SGTC_3238 9133470 49.47 µM -1.18804095810381 0.134669070692003 no 2938 0.11740863677415 4274 3534688
SGTC_3158 9100007 49.47 µM -1.19025172220262 0.13417699157946 no 2939 0.116973734859199 4299 19297233
SGTC_883 0850-0245 24.6 µM -1.19440162413716 0.133256631406026 no 2940 0.1161604509143 4353 6823229 YPR165W RHO1
SGTC_2872 9044037 25.97 µM -1.19518116842026 0.133084230811165 no 2941 0.116008127233781 4310 6465195
SGTC_1821 st053465 65.6 µM -1.19569897383313 0.132969800126873 no 2942 0.115907025981691 4292 675086
SGTC_809 3998-0021 90 µM -1.1960875898682 0.132883963726433 no 2943 0.11583118999803 4236 715485
SGTC_1895 st058434 18.3 µM -1.19671434832614 0.132745607507569 no 2944 0.115708956263784 4292 5393175
SGTC_1350 1495-0454 146 µM -1.19958255772544 0.13211371961002 no 2945 0.115150751994315 4324 1069057
SGTC_1361 1608-0041 5.61 µM -1.20044485081633 0.131924156168031 no 2946 0.114983309452124 4255 X1361
SGTC_763 3453-1109 128 µM -1.20135030717212 0.131725305890142 no 2947 0.114807671802921 4306 1560353
SGTC_649 1123-0311 367 µM -1.20446406400854 0.131043062380341 no 2948 0.114205131798266 4196 693629 YIL048W NEO1
SGTC_2139 5578692 56.4705 µM -1.21098469000454 0.129622272199765 no 2949 0.112950636201552 4264 650991 YMR113W FOL3
SGTC_2201 6605497 169.863 µM -1.21102478942273 0.129613568009123 no 2950 0.112942952072403 4227 670741
SGTC_1119 parthenolide 318.541 nM -1.2125307920211 0.129286960271078 no 2951 0.112654631506344 4381 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2848 9016370 25.97 µM -1.21282073425996 0.129224145853212 no 2952 0.112599183157167 4292 7894410
SGTC_1545 lovastatin 49.4 µM -1.21293789426876 0.129198769773175 no 2953 0.112576783090196 4327 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2127 5253358 187.912 µM -1.21922160991746 0.127842817353725 no 2954 0.111380046023512 4204 20612
SGTC_21 0849-0113 22.993 µM -1.22022277021855 0.127627695362038 no 2955 0.111190218614802 4261 1560156
SGTC_2166 5933061 31.504 µM -1.22299663784863 0.127032982004805 no 2956 0.110665483090824 4416 2877375
SGTC_2064 5220758 200 µM -1.22489384820361 0.126627335070999 no 2957 0.110307609289298 4356 788518
SGTC_3263 9137018 49.47 µM -1.22502644715949 0.126599017549565 no 2958 0.110282628003188 4267 43844957
SGTC_3021 9087658 49.47 µM -1.22699276231549 0.126179613510581 no 2959 0.109912655619784 4301 25237042
SGTC_597 k018-0003 82.8 µM -1.22815583752884 0.125931992403381 no 2960 0.109694236674323 4378 6786234
SGTC_846 0335-0850 148 µM -1.23073187664699 0.125384755379409 no 2961 0.109211580868589 4281 6819598
SGTC_2696 st077691 74.316 µM -1.23236651137729 0.125038366257049 no 2962 0.108906102347874 4363 757133
SGTC_1286 0929-0070 131 µM -1.23438738297441 0.124611055863318 no 2963 0.108529294115861 4389 1420408
SGTC_2450 5739737 12.93 µM -1.23589686540481 0.124292544686105 no 2964 0.108248451172417 4342 2262825
SGTC_255 tunicamycin 200.472 nM -1.23898837291624 0.123641993742764 no 2965 0.10767490199691 4242 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_585 0kpi-0023 191 µM -1.24113815423425 0.123191019603293 no 2966 0.107277358432174 4256 64601
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.24188446623134 0.123034730589559 no 2967 0.107139596088664 4354 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1212 0520-0165 585 µM -1.24345200099682 0.122706917815259 no 2968 0.106850659050229 4431 5403258
SGTC_2319 6033012 152.6 µM -1.24852459986482 0.121650304728251 no 2969 0.105919502701774 4274 847246
SGTC_2265 7929201 200 µM -1.24883091355327 0.121586705486423 no 2970 0.105863462288198 4308 1265108
SGTC_2984 9022109 38.96 µM -1.25074743568154 0.121189312702168 no 2971 0.105513318990303 4358 6459207
SGTC_946 3434-1334 87.4 µM -1.25126506767643 0.121082138052172 no 2972 0.105418892872414 4305 4047976
SGTC_1980 st071811 45.7 µM -1.25356740820437 0.120606251011203 no 2973 0.104999641832474 4402 4974850
SGTC_1774 st048371 48.465 µM -1.25448427617526 0.12041710420928 no 2974 0.104833018701264 4316 4242727
SGTC_1603 st002045 67.8 µM -1.25664061803546 0.119973081854573 no 2975 0.104441899830575 4336 5887985
SGTC_423 5-fluorouracil 457 µM -1.25744617471009 0.119807502411306 no 2976 0.104296058975711 4265 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2714 st079313 56.9 µM -1.26665841932399 0.117925408084048 no 2977 0.102638726946493 4326 2939799
SGTC_1875 nocodazole 6 µM -1.26696225071078 0.117863692591947 no 2978 0.102584394034601 4361 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3061 glucosamine 200 µM -1.26718186926399 0.117819096991849 no 2979 0.102545133576473 4284 91431 and experimental redox chemotherapeutic
SGTC_2992 9074591 71.4286 µM -1.26788222978198 0.117676961996073 no 2980 0.102420005483166 4289 17741321
SGTC_2069 5228469 200 µM -1.26996877897955 0.117254225816859 no 2981 0.102047875768662 4347 2835210
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.26998565219132 0.11725081168369 no 2982 0.102044870497909 4341 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_743 1275-0778 158 µM -1.2716325650191 0.116917913398623 no 2983 0.10175185032917 4327 2849257 YMR203W TOM40
SGTC_1697 st025554 27.742 µM -1.2722678033434 0.116789688862835 no 2984 0.101638992025279 4358 1269519
SGTC_328 k915-0120 63.5 µM -1.27240799802684 0.116761403628746 no 2985 0.101614096908943 4352 6624543
SGTC_2475 5812728 15.03 µM -1.27361654990707 0.116517771414935 no 2986 0.101399672020118 4297 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2602 kawain 100 µM -1.27665587581242 0.115906667249076 no 2987 0.100861882877454 4333 5369129
SGTC_2655 perillic acid 100 µM -1.27869733462745 0.115497479644365 no 2988 0.100501829331361 4378 5702197 An apoptosis inducer.
SGTC_1728 st035614 33.7865 µM -1.28048620743441 0.115139764761909 no 2989 0.100187096229109 4292 15945546
SGTC_2460 5552655 174.22 µM -1.28134203864345 0.114968905932509 no 2990 0.100036776558768 4366 5401989
SGTC_258 haloperidol 50.781 µM -1.28539488322 0.114162241739435 no 2991 0.0993271641736514 4355 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2083 5306046 65.942 µM -1.28575650431613 0.114090462304624 no 2992 0.0992640272344196 4342 539837
SGTC_1190 1486-1332 13 µM -1.28674503953603 0.113894408569364 no 2993 0.0990915844941484 4359 4150046
SGTC_248 streptozotocin 5.23457 mM -1.28876983370824 0.113493585895499 no 2994 0.0987390581683822 4389 5300 DNA alkylating agent.
SGTC_2033 5192550 145 µM -1.2890564354236 0.113436932375702 no 2995 0.0986892336880883 4358 182073
SGTC_2117 5521686 200 µM -1.28923398415791 0.113401845842169 no 2996 0.0986583768336274 4332 803312
SGTC_265 mycophenolic acid 32.932 µM -1.28986832769244 0.113276552413628 no 2997 0.0985481895996037 4416 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3086 9117350 49.47 µM -1.29355336822028 0.112550648406599 no 2998 0.097909869302589 4308 2679265
SGTC_3352 9151559 45.5865 µM -1.29549950372459 0.112168629090332 no 2999 0.0975739862239134 4378 17159339
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.29725601652871 0.111824628555023 no 3000 0.0972715562779496 4374 77254
SGTC_806 3966-4455 5.86 µM -1.3011350444076 0.111067623117204 no 3001 0.0966061171008064 4339 714982
SGTC_2516 gossypol 71.55 µM -1.30140244657576 0.111015574223483 no 3002 0.0965603683234093 4380 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3229 9132204 49.47 µM -1.30689557641325 0.109950219011499 no 3003 0.0956240893357862 4449 17682924
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.3103219885293 0.109289416087373 no 3004 0.0950434659642356 4426 165506
SGTC_1758 st042942 75.2445 µM -1.31079178622151 0.10919903583792 no 3005 0.094964059168293 4347 669317
SGTC_1305 1181-0477 144 µM -1.3158436303295 0.108230548248112 no 3006 0.0941132659080624 4436 6252086
SGTC_2965 9082772 38.63 µM -1.31855689364766 0.107712948468701 no 3007 0.0936586464136586 4384 16459634
SGTC_2456 5770359 74.46 µM -1.31860121075398 0.107704509076146 no 3008 0.093651234365112 4383 3118787
SGTC_774 k060-0086 136 µM -1.32047530667126 0.107348057264413 no 3009 0.0933381875927541 4376 5911235
SGTC_1266 0828-0227 32.9 µM -1.32067700951253 0.107309744265162 no 3010 0.0933045415212041 4354 3913820
SGTC_19 0279-0214 38.434 µM -1.32086806721204 0.107273462378826 no 3011 0.0932726794314853 4448 3566274 YBR002C RER2
SGTC_2115 tiliquinol 12.7705 µM -1.32264660607167 0.106936141884319 no 3012 0.0929764637692727 4363 71208 A bioactive hydroxyquinoline.
SGTC_3081 9117243 49.47 µM -1.32424513816464 0.106633615292445 no 3013 0.0927108221501525 4355 45595589
SGTC_1098 clofazimine 15.1 µM -1.32566483569238 0.106365452005019 no 3014 0.0924753699806757 4434 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3135 9127742 49.47 µM -1.32739768569486 0.10603879848529 no 3015 0.0921885824296429 4456 3643468
SGTC_2142 5622915 118.518 µM -1.32839089627492 0.105851898918891 no 3016 0.0920245026812663 4388 5322196
SGTC_327 1273-0057 3.96 µM -1.33140404112866 0.105286350927 no 3017 0.0915280502190279 4288 3108138
SGTC_506 n9-isopropylolomoucine 153 µM -1.33242142356693 0.10509588933388 no 3018 0.0913608730558035 4394 6610355
SGTC_1007 4101-0031 70 µM -1.33818388004147 0.104021819321241 no 3019 0.0904182512967771 4380 1146276
SGTC_1003 4049-0218 100 µM -1.34117854231226 0.103466794503641 no 3020 0.0899312456929622 4393 295161
SGTC_1168 k815-0004 80.5 µM -1.3443444786666 0.10288236680772 no 3021 0.0894185093803571 4384 642433
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.34556366657931 0.1026579471738 no 3022 0.0892216379143589 4439 91467 include heat shock
SGTC_2300 7976697 71.57 µM -1.34580566146475 0.102613444791523 no 3023 0.089182599566062 4294 2236109
SGTC_2816 7982706 58.44 µM -1.34764887252441 0.102274942029956 no 3024 0.0888856718030986 4378 2981853
SGTC_1093 fluphenazine 7.97 µM -1.34966970785125 0.101904753024518 no 3025 0.0885609766022658 4438 6602611 An atypical antipsychotic.
SGTC_1388 3346-4487 254 µM -1.35016808298015 0.10181360770561 no 3026 0.0884810367881853 4468 3345614
SGTC_627 1391-0720 175 µM -1.35199014234572 0.101480885516741 no 3027 0.0881892343894405 4369 997839
SGTC_2129 girgensonine 121.053 µM -1.35205583194105 0.101468904894477 no 3028 0.0881787276286509 4402 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1696 st025591 34.7925 µM -1.35442423655583 0.101037637633163 no 3029 0.0878005347921291 4402 2787147
SGTC_2432 5630864 12.22 µM -1.35576229239127 0.100794579952988 no 3030 0.0875874062171875 4403 5714970
SGTC_1843 st055809 45.5 µM -1.356085203492 0.100735987107984 no 3031 0.0875360300741892 4447 16413835
SGTC_588 3970-1144 52.9 µM -1.35861156069316 0.100278431921301 no 3032 0.0871348549388873 4296 1888707
SGTC_598 3937-0236 20.2 µM -1.36055208166707 0.0999280104880415 no 3033 0.0868276417309505 4469 1379313
SGTC_697 0508-1955 564 µM -1.36114977173534 0.0998202593108379 no 3034 0.0867331817562871 4412 6243113
SGTC_1716 st033144 30.6155 µM -1.36180269370916 0.0997026479858411 no 3035 0.0866300806264964 4403 674617
SGTC_542 3381-0244 89.3 µM -1.36590648090413 0.0989657470370327 no 3036 0.0859841591550877 4429 1112843
SGTC_2627 acetyl isogambogic acid 100 µM -1.36879738271786 0.0984490364245589 no 3037 0.0855313096302199 4414 6857789 A caspase activator and apoptosis inducer.
SGTC_661 1304-0007 33.6 µM -1.37009840824132 0.0982171408816338 no 3038 0.0853280923289801 4426 3117130
SGTC_249 wiskostatin 11.211 µM -1.37274758474555 0.0977461874628527 no 3039 0.0849154152796145 4389 2775510 A n-wasp and actin depolymerizer.
SGTC_1872 amphotericin b 148 nM -1.37349242663725 0.0976140729586229 no 3040 0.0847996570044412 4423 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_618 k072-0232 33.2 µM -1.37994120926306 0.0964757067667602 no 3041 0.0838023735153971 4460 5872756 YGL099W LSG1
SGTC_79 0052-0007 94.094 µM -1.38004930946442 0.0964567079440448 no 3042 0.0837857315657195 4406 2801472
SGTC_359 0081-0058 15.9 µM -1.38073722121084 0.0963358705101824 no 3043 0.0836798861957378 4463 3494159
SGTC_500 h-89 112 µM -1.3809815840754 0.0962929729257575 no 3044 0.0836423115542432 4398 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1622 st003707 19.4 µM -1.38268744107767 0.0959939029699012 no 3045 0.0833803622025161 4429 10140899
SGTC_1988 st071872 53.4 µM -1.38595570423783 0.0954228217645707 no 3046 0.0828802148572862 4448 16414116
SGTC_1643 st009866 20.2 µM -1.38595921667736 0.0954222093653317 no 3047 0.082879678560065 4383 3156273 YOR207C RET1
SGTC_425 3825-7017 13.1 µM -1.38598536016812 0.095417651298381 no 3048 0.0828756869203013 4447 3397440
SGTC_3216 9129716 49.47 µM -1.38650752977648 0.0953266456048642 no 3049 0.0827959913241056 4351 8056934
SGTC_1611 st001856 99.4 µM -1.38881408476087 0.0949254149856341 no 3050 0.0824446455831715 4408 647478
SGTC_1886 st057356 49.9 µM -1.39473596481221 0.0939009903077527 no 3051 0.0815477376395145 4417 24207747
SGTC_931 2812-0076 566 µM -1.39559211442997 0.0937535628487502 no 3052 0.0814186792033977 4353 3450959
SGTC_2661 dactinomycin 12.96 µM -1.39963074934042 0.0930604207591825 no 3053 0.0808119604907446 4401 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2130 NSC 7 2.4545 µM -1.39999573193522 0.0929979667078936 no 3054 0.0807572982822026 4489 21448
SGTC_111 0083-0039 52.457 µM -1.40016211340145 0.0929695066018603 no 3055 0.0807323891593902 4389 759313
SGTC_1685 st024049 53.0905 µM -1.40185807785369 0.0926797734359246 no 3056 0.0804788156409561 4446 1941139
SGTC_1167 k781-0610 148 µM -1.4073408363122 0.0917476860231629 no 3057 0.0796631728608872 4466 4525169
SGTC_1892 st058411 7.36 µM -1.41223010829208 0.0909223669234354 no 3058 0.0789411089866607 4440 3934738
SGTC_2370 9071495 200 µM -1.41320636984403 0.0907582337235088 no 3059 0.0787975270830993 4446 21791103
SGTC_1293 1000-1278 195 µM -1.41370908468043 0.0906738010013362 no 3060 0.0787236684289494 4456 678847
SGTC_2647 atorvastatin 60.16 µM -1.4211437707981 0.0894319179608977 no 3061 0.0776374836928175 4425 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_192 3455-0609 60.9 µM -1.42190917464498 0.0893047874171294 no 3062 0.0775263097158511 4509 3769639
SGTC_1000 4048-0884 8.67 µM -1.42303376380574 0.0891182415844396 no 3063 0.0773631838578482 4461 13040088
SGTC_404 fumagillin 50 µM -1.42389310818553 0.0889758898965326 no 3064 0.0772387085742366 4450 12015870 A methionine aminopeptidase binder.
SGTC_2949 9072542 2.23 µM -1.42779173117439 0.0883322025069502 no 3065 0.0766759067829065 4433 16457352
SGTC_651 3253-0966 34.4 µM -1.42963947931147 0.0880283424645228 no 3066 0.0764102592334786 4468 781462
SGTC_975 1335-0046 28.5 µM -1.43094594706168 0.0878139661714666 no 3067 0.0762228536209115 4453 16486740
SGTC_3284 9108171 64.8615 µM -1.4373836236071 0.0867633020691893 no 3068 0.075304509715477 4437 8687505
SGTC_1256 0570-0116 285 µM -1.44004275981708 0.0863320684624765 no 3069 0.0749276509183124 4461 410638
SGTC_2297 7971671 152.32 µM -1.44074952706476 0.0862177216965787 no 3070 0.0748277286702048 4454 909016
SGTC_416 estradiol valerate 100 µM -1.44249976420947 0.0859350412420482 no 3071 0.0745807190302642 4460 13791 A steroid.
SGTC_1531 st059297 52.4 µM -1.44431605643166 0.0856424261726763 no 3072 0.0743250456224085 4496 7566702
SGTC_1725 st036284 20.55 µM -1.44499662390295 0.0855329752060142 no 3073 0.07422941697025 4485 707914
SGTC_474 dl-dihydrosphingosine 5 µM -1.44506082420484 0.0855226557240303 no 3074 0.0742204008386453 4459 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_293 4049-0273 38.5 µM -1.45088852684114 0.0845897964279417 no 3075 0.0734054515971953 4331 1380311
SGTC_785 1270-0111 65.3 µM -1.45166046411977 0.0844668045854198 no 3076 0.0732980187510798 4386 6741994
SGTC_2187 6125751 200 µM -1.4539601791314 0.0841011889931869 no 3077 0.0729786733488968 4491 874498
SGTC_1417 3966-0327 90.4 µM -1.45924439822057 0.0832655911819039 no 3078 0.0722489264313965 4543 651118
SGTC_2857 9024691 58.44 µM -1.46052781534488 0.0830635886713037 no 3079 0.0720725343504098 4498 16478292
SGTC_1464 k208-0027 110 µM -1.46075447266352 0.0830279524312884 no 3080 0.0720414170340367 4471 X1464
SGTC_3309 9129340 25.759 µM -1.46809226114133 0.081880469912287 no 3081 0.0710395817162285 4466 17158987
SGTC_2556 citropten 84.59 µM -1.46821828815187 0.0818608667518421 no 3082 0.0710224690694871 4483 2775 A potential DNA crosslinker.
SGTC_1450 4112-4260 37.6 µM -1.47042748545877 0.081517806292149 no 3083 0.0707230059263687 4473 1633175
SGTC_2076 5212012 200 µM -1.47168312768151 0.0813233047288568 no 3084 0.0705532329455391 4461 604802
SGTC_193 1273-0060 1.558 µM -1.47374628084086 0.0810044785511046 no 3085 0.0702749584208182 4323 2847393 YHR072W ERG7
SGTC_1817 st052116 64.4 µM -1.47959790550103 0.0801053397195423 no 3086 0.0694902929013653 4508 4361398
SGTC_2663 amphotericin b 100 µM -1.48416947080898 0.0794081554823251 no 3087 0.0688819833888718 4519 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3345 9148410 3.559 µM -1.48459653800259 0.0793432611037292 no 3088 0.0688253665534273 4426 4903596
SGTC_771 0250-0039 27.3 µM -1.48554959060371 0.0791985861372719 no 3089 0.0686991485488838 4429 3005115
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.4887386769662 0.0787159297931627 no 3090 0.0682780980017558 4509 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2006 4011487 200 µM -1.48895163994654 0.0786837782077516 no 3091 0.0682500518938839 4455 45595294
SGTC_564 3555-0129 330 µM -1.49007919950387 0.0785137133728173 no 3092 0.068101706346652 4388 563260
SGTC_1950 st077106 7.18 µM -1.49039857683256 0.078465593774624 no 3093 0.0680597332543953 4393 13831864
SGTC_161 4065-0411 162.148 µM -1.4914497359644 0.0783073767518001 no 3094 0.0679217292265005 4478 1906281 YLR208W SEC13
SGTC_53 0973-0023 39.979 µM -1.49815610411533 0.0773036465527974 no 3095 0.0670463486647971 4400 674768
SGTC_1370 2001-0092 44.6 µM -1.50188031060415 0.0767504880436393 no 3096 0.0665640112195433 4483 790957
SGTC_1509 1326-1131 80 µM -1.50207265914801 0.0767220003558835 no 3097 0.0665391724965346 4479 768313
SGTC_2373 9071805 200 µM -1.50228041157643 0.0766912403162588 no 3098 0.0665123526697294 4506 10149009
SGTC_3197 9113331 49.47 µM -1.50473689440152 0.0763282416356326 no 3099 0.06619586682731 4478 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1752 st044819 83.042 µM -1.50565643668207 0.0761926961126513 no 3100 0.066077696263655 4444 441209 YML126C ERG13
SGTC_2415 st077333 57.7 µM -1.50944890735483 0.0756356007228405 no 3101 0.0655920513734214 4506 2766255
SGTC_801 0866-0028 10.1 µM -1.50980729533059 0.0755831161883122 no 3102 0.0655463014964659 4533 6849771
SGTC_995 3931-2021 34.6 µM -1.51359527178628 0.0750300771116074 no 3103 0.0650642605369805 4516 730143
SGTC_1453 4237-0541 195 µM -1.51783250841015 0.0744151095605665 no 3104 0.064528313826631 4507 739892
SGTC_1491 4138-0063 26.5 µM -1.51935367025789 0.0741952783270396 no 3105 0.0643367485151478 4510 23883227
SGTC_320 4092-0846 5.34 µM -1.52635713809264 0.0731895638114063 no 3106 0.0634604729777305 4478 1359356
SGTC_734 2023-0417 80 µM -1.52756553181139 0.0730170957043432 no 3107 0.0633102225620357 4515 3935732
SGTC_2718 lomofungin 53.02 µM -1.52986044058581 0.0726904111577515 no 3108 0.0630256385704956 4481 5351222 A RNA synthesis inhibitor.
SGTC_186 3455-3465 67.277 µM -1.53081144110123 0.0725553629365419 no 3109 0.062908000574796 4511 755278
SGTC_1588 farnesol 29.9 µM -1.53105859810964 0.072520296526411 no 3110 0.0628774554757307 4524 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1795 st049545 62.3 µM -1.53479017880711 0.0719924396473156 no 3111 0.0624176880055987 4466 5291882
SGTC_1845 st056753 3.01 µM -1.53532710781369 0.0719167305216634 no 3112 0.0623517493502165 4477 5375839
SGTC_3012 9080433 71.4286 µM -1.54031840263557 0.0712158570592298 no 3113 0.0617413800960043 4501 17688859
SGTC_1740 st038286 13.222 µM -1.54433041668358 0.0706563047745308 no 3114 0.0612541537702386 4520 716786
SGTC_2035 5154463 94.595 µM -1.545272366534 0.0705254228669677 no 3115 0.0611401982858745 4536 2769623
SGTC_1840 st055363 71 µM -1.54731292944749 0.0702425302729155 no 3116 0.0608939027406253 4539 676033
SGTC_2447 5741742 33.78 µM -1.55159977369842 0.0696510687661433 no 3117 0.060379008674797 4571 1776504
SGTC_1979 st071809 45.3 µM -1.55424103598967 0.0692885638581271 no 3118 0.0600634662290756 4563 4976333
SGTC_653 0203-0016 55.2 µM -1.56032618790406 0.0684589288675216 no 3119 0.0593414089193645 4588 295302
SGTC_2504 purpurogallin 52.29 µM -1.56126564785768 0.0683315309275768 no 3120 0.0592305426423246 4469 5281571 An antioxidant.
SGTC_1118 chelidonine 707.474 nM -1.56539479482407 0.0677737551643371 no 3121 0.0587451840802171 4524 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2215 7188065 200 µM -1.56635679145679 0.0676443126919843 no 3122 0.0586325562355612 4587 940217
SGTC_2435 5706476 10.6 µM -1.57228780041507 0.0668504743149397 no 3123 0.057941910506785 4518 5725375
SGTC_876 0720-0963 56.8 µM -1.57234216569396 0.0668432312522155 no 3124 0.0579356095596671 4544 765861
SGTC_2724 maprotiline 69.64 µM -1.57952296436464 0.06589186216224 no 3125 0.057108076696071 4475 4011 A tricyclic antidepressant.
SGTC_2342 7990637 118.86 µM -1.58631119368006 0.0650021847292171 no 3126 0.0563343671603446 4524 2033102 YER133W GLC7
SGTC_503 tyrphostin 8 294 µM -1.59179982683017 0.0642896752374742 no 3127 0.0557148445448522 4552 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_284 0988-0104 32.6 µM -1.59346080979301 0.0640752545896515 no 3128 0.0555284266629866 4522 4666532
SGTC_2420 aureobasidin a 50 nM -1.59404148043036 0.0640004255956363 no 3129 0.0554633722632424 4590 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1625 st003711 30.1 µM -1.59570590559757 0.0637863134493078 no 3130 0.0552772347545662 4549 24207034 YER133W GLC7
SGTC_868 0527-0199 213 µM -1.59734486580542 0.0635760219971524 no 3131 0.0550944275104833 4539 2849450
SGTC_23 0213-0011 39.996 µM -1.59999350175295 0.0632373220935702 no 3132 0.054800012494292 4530 627608
SGTC_1698 5-fluorocytosine 1.055 µM -1.60429674567377 0.0626900333602562 no 3133 0.0543243290526188 4561 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1923 st058458 19.1 µM -1.60583270139306 0.0624955861485285 no 3134 0.0541553367236664 4527 3534982
SGTC_173 1273-0061 2.693 µM -1.60748899286819 0.0622864320668644 no 3135 0.0539735710337302 4499 2847414 YPL266W DIM1
SGTC_2938 9059746 27.26 µM -1.60945492506876 0.0620388860243366 no 3136 0.0537584517859672 4526 6471769
SGTC_2068 5226020 147 µM -1.61139541546233 0.0617952970404965 no 3137 0.05354678291957 4560 1810509
SGTC_2994 9053520 71.4286 µM -1.61474405251937 0.0613767005672985 no 3138 0.0531830667078913 4558 4647384
SGTC_2365 9042475 200 µM -1.62176460014244 0.0605062895944297 no 3139 0.0524268804174348 4582 6464479
SGTC_2 0422-0095 29 µM -1.62201711408342 0.0604751636590522 no 3140 0.0523998418855927 4476 6790840
SGTC_3285 9112818 20.8695 µM -1.62327641988744 0.0603201233047512 no 3141 0.0522651639577452 4545 17017947 YPR165W RHO1
SGTC_2523 spermine 47.74 µM -1.62411269745005 0.0602173363899095 no 3142 0.0521758792635842 4553 1103 A DNA binding polyamine.
SGTC_2205 7238770 200 µM -1.62748043398641 0.0598047949908677 no 3143 0.0518175504088028 4592 279867
SGTC_2701 st077767 14.721 µM -1.62823627192371 0.0597125111826121 no 3144 0.0517373982284589 4523 5721188
SGTC_817 1391-0715 46 µM -1.63252785179137 0.059190645614793 no 3145 0.0512841680497995 4549 1353946
SGTC_137 0438-0332 85.389 µM -1.63574360267926 0.058801952714854 no 3146 0.0509466298913197 4508 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2713 st079149 53.4 µM -1.63831349912365 0.0584927676758088 no 3147 0.0506781565627997 4578 3103253
SGTC_3222 9128301 49.47 µM -1.64022858629995 0.0582631941481471 no 3148 0.0504788238459921 4518 4911358
SGTC_2752 diclazuril 33.15 µM -1.64747552503177 0.0574008595142388 no 3149 0.0497301714267358 4478 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1040 k898-0338 155 µM -1.64910833456158 0.0572079597179354 no 3150 0.0495627212319376 4552 20969351
SGTC_3174 9107204 49.47 µM -1.6543366670737 0.0565937164024902 no 3151 0.0490295634000531 4563 3938802
SGTC_1683 st010134 710 nM -1.65837457634764 0.0561228941395218 no 3152 0.0486209424274433 4532 3818134
SGTC_1713 st033146 12.748 µM -1.66315256536938 0.0555697741246555 no 3153 0.0481409499891474 4544 674619
SGTC_777 1315-0167 517 µM -1.66523877348369 0.0553296195447959 no 3154 0.047932564105165 4595 4221767
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.66621447637984 0.0552175828251373 no 3155 0.0478353518220411 4542 364106
SGTC_2858 9025781 8.96 µM -1.66702601197058 0.0551245334595545 no 3156 0.0477546163332652 4401 4894980 YPL153C RAD53
SGTC_3249 9135183 49.47 µM -1.66883871136814 0.0549171396332537 no 3157 0.0475746742710768 4529 4902779
SGTC_2242 6630449 61.2675 µM -1.67377342092536 0.0543556751603585 no 3158 0.0470875689331088 4580 691249 YDR170C SEC7
SGTC_592 k241-0073 46.5 µM -1.6763190975206 0.0540678123942163 no 3159 0.0468378530721024 4617 4230158
SGTC_1389 3405-0187 19 µM -1.68489472057614 0.0531069596495233 no 3160 0.0460044426746857 4573 799890
SGTC_12 0849-0099 9.267 µM -1.6881329677857 0.0527476723643902 no 3161 0.0456928535920162 4548 6071388
SGTC_2561 acetosyringone 100 µM -1.69433434069129 0.0520650079155319 no 3162 0.0451008842810642 4544 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2177 5811945 192 µM -1.70253222098473 0.0511733554918102 no 3163 0.0443278218278803 4592 5343475
SGTC_360 0957-0399 1.01 µM -1.70626148783492 0.0507717786040929 no 3164 0.0439797025441339 4600 6752301 YPR165W RHO1
SGTC_1628 st004252 77.7 µM -1.70774385491367 0.0506128522123618 no 3165 0.0438419404766227 4586 692968
SGTC_467 ro 31-8220 72.8 µM -1.70893403062465 0.050485539016727 no 3166 0.0437315849913056 4582 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2723 salbutamol 83.58 µM -1.71634436928969 0.0496985845801924 no 3167 0.0430495160113972 4605 9884233 β2-adrenoceptor agonist
SGTC_2446 5162541 200 µM -1.71919826086642 0.0493981333546405 no 3168 0.0427891386963533 4571 1549321
SGTC_75 0159-0059 199.013 µM -1.72027058221598 0.0492856172681791 no 3169 0.0426916341132246 4613 5377270
SGTC_2841 9004761 38.96 µM -1.72779792901692 0.0485015402820283 no 3170 0.0420122294128844 4545 2991039
SGTC_1044 1222-0021 1.78 µM -1.72883081584023 0.0483947334432096 no 3171 0.0419196895805088 4525 4306703
SGTC_3341 9147222 25.867 µM -1.73048712334756 0.0482238538511071 no 3172 0.0417716399395439 4598 1939759
SGTC_2309 7664088 163.95 µM -1.73694713446086 0.047561989094979 no 3173 0.0411982513061721 4575 704922
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.73831716168819 0.0474225615953647 no 3174 0.041077472022707 4570 688761
SGTC_2528 xanthyletin 44.79 µM -1.73879167312587 0.0473743470518679 no 3175 0.0410357069053935 4615 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2522 biochanin a 4.94 µM -1.73963993128144 0.0472882544275348 no 3176 0.040961131501794 4600 5280373 A possible chelator.
SGTC_131 0141-0277 33.849 µM -1.7430976519624 0.0469386150276976 no 3177 0.040658279351601 4557 1547771
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.74794984622433 0.0464514678998265 no 3178 0.0402363561958105 4629 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2401 5128683 200 µM -1.75207153933573 0.0460408563205015 no 3179 0.0398807537002044 4582 708373
SGTC_2220 6782180 200 µM -1.75592256411455 0.0456598489535016 no 3180 0.0395508157888381 4575 833803
SGTC_475 α-linolenic acid 10 µM -1.75899744543603 0.0453574539649919 no 3181 0.0392889712301373 4607 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1853 st056710 91.2 µM -1.7595423790193 0.0453040316331564 no 3182 0.0392427143550997 4626 269167
SGTC_3261 9137475 49.47 µM -1.76204043361823 0.0450597834280934 no 3183 0.0390312330987414 4645 17027690
SGTC_362 0310-0100 9.03 µM -1.7707970980654 0.0442119549117828 no 3184 0.038297224346028 4630 790235
SGTC_121 0557-0495 61.343 µM -1.77391992709956 0.0439127284373932 no 3185 0.0380381980462776 4635 3104427
SGTC_1336 1486-0901 104 µM -1.77418090597035 0.0438877958277146 no 3186 0.0380166157474086 4616 5006114
SGTC_27 0485-0001 32.618 µM -1.77556184914359 0.0437560574530765 no 3187 0.0379025814294547 4625 2054479
SGTC_1189 1431-2119 7.28 µM -1.78263018307644 0.0430867444798256 no 3188 0.037323261584166 4624 3107275
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.78360033674625 0.0429955278425267 no 3189 0.0372443154306796 4580 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2532 xanthone 78.9 µM -1.78381094447388 0.0429757465248258 no 3190 0.0372271952853925 4624 7020 An insecticide.
SGTC_514 4466-0038 2.65 nM -1.78421840481636 0.0429374967131683 no 3191 0.0371940913916524 4427 5722064
SGTC_1631 benzylvanillin 81.9 µM -1.7850391471479 0.0428605341028824 no 3192 0.0371274836503083 4618 75506
SGTC_2477 5967686 25.23 µM -1.78537198282565 0.0428293552415799 no 3193 0.0371005000056184 4612 776118
SGTC_1310 1188-0297 994 nM -1.78921673816767 0.0424705195198985 no 3194 0.0367899585196643 4519 1588352
SGTC_1786 berberine 21.6 µM -1.79447972460941 0.0419832649873831 no 3195 0.0363683159831163 4538 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1507 4075-3230 155 µM -1.79469965866629 0.0419630021078035 no 3196 0.0363507824863805 4591 659771
SGTC_314 1671-0008 2.74 µM -1.798516130653 0.0416126434211454 no 3197 0.0360476273831401 4503 3913060
SGTC_2565 isoliquiritigenin 100 µM -1.81430048318933 0.0401887010929093 no 3198 0.0348157386121987 4598 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1694 st024011 44.9 µM -1.81924352167754 0.0397510055138911 no 3199 0.0344371428466212 4666 2787533
SGTC_1411 3909-8223 150 µM -1.82208288379469 0.0395013436049477 no 3200 0.0342212051996091 4674 X1411
SGTC_700 3453-2283 142 µM -1.82427679818689 0.0393093099565202 no 3201 0.0340551181265059 4667 565664
SGTC_3064 1327-0027 10 µM -1.82612813401389 0.0391478538709628 no 3202 0.0339154816422446 4619 16000455 YPR107C YTH1
SGTC_2874 9043904 71.43 µM -1.83311567151581 0.0385433236210627 no 3203 0.0333926855152718 4559 4463428
SGTC_487 nimodipine 119 µM -1.8366496972847 0.0382404849591829 no 3204 0.0331308128408227 4658 4497 L-type voltage-gated calcium channels inhibitor
SGTC_432 NS 1619 61.3 µM -1.83726725913172 0.0381877643706155 no 3205 0.0330852253889783 4590 4552 A K+/calcium channel activator.
SGTC_251 melphalan 456.522 µM -1.83781332984924 0.0381411962958624 no 3206 0.0330449583671916 4670 460612 A DNA alkylator.
SGTC_1953 st076800 12.1 µM -1.84346910178794 0.0376615995899053 no 3207 0.0326302744886187 4605 297591
SGTC_3167 9103034 49.47 µM -1.84533339385012 0.0375045948927252 no 3208 0.0324945278086136 4700 5127859
SGTC_3129 9127257 49.47 µM -1.84609481590581 0.0374406242888458 no 3209 0.0324392197259974 4592 837894
SGTC_1059 3448-6867 171 µM -1.8513617605783 0.0370005601805456 no 3210 0.0320587632309741 4606 3934407
SGTC_73 0327-0325 16.231 µM -1.85561654076221 0.0366481598279536 no 3211 0.0317541171638818 4461 53298
SGTC_2184 6075246 200 µM -1.85627327119653 0.036594011798223 no 3212 0.0317073084490396 4641 2267320
SGTC_2691 st077356 60.2 µM -1.85653613128847 0.0365723570907033 no 3213 0.0316885889785047 4606 2839272
SGTC_2955 9076254 12.21 µM -1.86341843534311 0.0360091058183826 no 3214 0.0312017091469655 4601 16459619
SGTC_967 1306-0166 352 µM -1.87301026930427 0.0352359761038373 no 3215 0.0305334834633298 4634 4437607
SGTC_2009 4012297 12.05 µM -1.87717552828544 0.0349045109879698 no 3216 0.0302470201923159 4597 45595307
SGTC_1508 1080-0625 72.9 µM -1.88737836887892 0.0341033877839014 no 3217 0.0295547262129491 4624 767111
SGTC_2124 5246320 200 µM -1.89155580947958 0.0337797683671353 no 3218 0.0292750942175651 4632 579342
SGTC_2929 9013348 24.6 µM -1.90592118631724 0.032686135995454 no 3219 0.0283302159236265 4621 2995952
SGTC_456 gingerol 170 µM -1.91905883833029 0.0317116907247782 no 3220 0.0274884439676538 4646 442793 A herb.
SGTC_495 decylubiquinone 155 µM -1.93025764183457 0.0309001204588398 no 3221 0.0267874613086633 4663 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1101 ebselen 5.29 µM -1.93070653100521 0.030867951442912 no 3222 0.0267596774016692 4687 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1813 st051246 8.6015 µM -1.93191011206662 0.0307818352693979 no 3223 0.0266853007311163 4639 5291959
SGTC_1309 pyrazolanthrone 13.4 µM -1.93259184616919 0.0307331455234031 no 3224 0.0266432488424795 4675 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2168 5727979 200 µM -1.93591065399205 0.0304970247974926 no 3225 0.0264393223325302 4599 695210
SGTC_2444 5485484 36.41 µM -1.93645776468301 0.0304582445846724 no 3226 0.0264058302858921 4689 6790631
SGTC_884 0851-0618 334 µM -1.93667954884714 0.0304425357562563 no 3227 0.026392263602094 4683 9642473
SGTC_2546 rhodinyl acetate 100 µM -1.93802088615988 0.0303476726982968 no 3228 0.0263103372146132 4622 6708682
SGTC_1787 fluconazole 80 µM -1.96005203131063 0.0288243074022212 no 3229 0.0249948545443386 4317 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3349 9149703 23.001 µM -1.96186653602015 0.0287017266402862 no 3230 0.0248890123742398 4677 4910494
SGTC_953 1188-0045 9.7 µM -1.97245154555792 0.0279952560494291 no 3231 0.0242790412599026 4645 6144426
SGTC_2469 5655019 90.81 µM -1.97313658856275 0.0279500379151752 no 3232 0.0242400013316052 4713 2788239
SGTC_730 1436-0052 41.2 µM -1.9764595509907 0.0277315590860457 no 3233 0.0240513763057056 4692 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2720 fluspirilene 36.88 µM -1.98205305176066 0.0273670110677189 no 3234 0.023736651651556 4684 3396 An atypical antipsychotic.
SGTC_732 3970-1727 52.7 µM -1.98335940499188 0.0272824495947789 no 3235 0.0236636490978745 4712 1275699
SGTC_1650 st011916 45.8 µM -1.98400841761527 0.027240519500806 no 3236 0.0236274507761933 4664 242528
SGTC_446 go6976 132 µM -1.99532917632035 0.0265177357080191 no 3237 0.02300349488506 4686 3501 A protein kinase C inhibitor.
SGTC_1734 st037168 69.4 µM -1.99991493133108 0.0262295492162823 no 3238 0.0227547252785661 4665 708907
SGTC_2219 9098279 200 µM -2.00156943153093 0.0261262189171964 no 3239 0.0226655297045962 4655 902349
SGTC_49 0717-0965 32.132 µM -2.00541047523883 0.025887641994066 no 3240 0.0224595913796473 4712 5889349 YGL099W LSG1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.0138578873545 0.0253693597614902 no 3241 0.0220122280219899 4673 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2564 betulinic acid 100 µM -2.01474372857268 0.0253155169569869 no 3242 0.0219657539104334 4649 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1117 retinoic acid 1.10837 µM -2.02856550586496 0.0244877334977157 no 3243 0.0212512824621758 4721 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1679 SEC14.276 6.7 µM -2.02938373688945 0.0244394505231209 no 3244 0.0212096101359265 4634 1005053 YMR079W SEC14
SGTC_70 0141-0289 43.283 µM -2.03589057353138 0.024058326234328 no 3245 0.0208806723003953 4664 352408
SGTC_3183 9108214 49.47 µM -2.03798037912401 0.0239369847243462 no 3246 0.0207759475697059 4719 4974831
SGTC_485 niflumic acid 177 µM -2.03876319109367 0.0238916645008716 no 3247 0.0207368338103639 4710 4488 A COX2 inhibitor.
SGTC_1427 4048-4900 550 nM -2.03999260214259 0.0238206343938425 no 3248 0.0206755312827983 4699 24132586
SGTC_183 3914-0051 30.55 µM -2.05505308509619 0.0229648177069297 no 3249 0.019936938812182 4681 1596232
SGTC_1573 oleylamine 1.06 µM -2.05803619089884 0.0227984114901455 no 3250 0.0197933297168473 4681 5356789 An amine of the fatty acid oleic acid.
SGTC_3052 9092717 49.47 µM -2.0591118142916 0.0227386598858727 no 3251 0.0197417641658335 4691 25237534
SGTC_2454 5-benzylidenerhodanine 10.36 µM -2.06619102920279 0.0223486886052663 no 3252 0.0194052227865567 4711 1273210
SGTC_3018 9082602 49.47 µM -2.07512438089968 0.0218646443788366 no 3253 0.0189875043259282 4591 17332089
SGTC_1656 st012921 11 µM -2.09205627687017 0.020971481607747 no 3254 0.0182167408830974 4625 6732821
SGTC_1642 st009582 77.7 µM -2.10149753472492 0.0204869999816003 no 3255 0.0177986570865521 4710 6739311
SGTC_3075 9116269 49.47 µM -2.10522957294623 0.0202981216412695 no 3256 0.0176356645946865 4691 17015205 YNL244C SUI1
SGTC_1073 triclabendazole 3.09 µM -2.11910632114032 0.0196087167964279 no 3257 0.017040741320602 4733 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2493 resveratrol 26.09 µM -2.1225477521207 0.0194408547950158 no 3258 0.0168958835773509 4699 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2499 avocadenofuran 51.48 µM -2.12848264498496 0.0191542374365147 no 3259 0.0166485436893916 4676 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1333 1482-0047 286 µM -2.13669274580018 0.0187636699165247 no 3260 0.0163114952105875 4716 3811116
SGTC_2824 7998404 51.95 µM -2.13817580032014 0.0186938462051389 no 3261 0.0162512388424047 4691 837851
SGTC_464 bw-b 70c 158 µM -2.14728188333285 0.0182699526320658 no 3262 0.0158854236152684 4700 5353454
SGTC_3266 9136860 49.47 µM -2.15998375106815 0.0176923714888934 no 3263 0.0153869637400304 4489 4871271 YPR165W RHO1
SGTC_3310 9130229 44.1445 µM -2.16208773347288 0.0175982190819696 no 3264 0.015305707175262 4703 7761258
SGTC_2186 6124449 200 µM -2.1623130861967 0.0175881600360256 no 3265 0.0152970258603518 4719 3834182 YLR033W RSC58
SGTC_617 3770-0098 35 µM -2.16265471057563 0.0175729203436444 no 3266 0.015283873450434 4668 5962639
SGTC_2211 7117706 200 µM -2.17872447777254 0.0168686812751163 no 3267 0.0146760711166802 4715 822771
SGTC_2582 agaric acid 100 µM -2.18222304951385 0.0167186012552777 no 3268 0.0145465374845633 4417 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_952 1185-0122 232 µM -2.18530533107154 0.0165873270221187 no 3269 0.01443323339 4685 678600
SGTC_1454 4239-0054 42.6 µM -2.19401428660517 0.0162211706404366 no 3270 0.0141171912477393 4745 1340767
SGTC_291 SEC14.278 35.5 µM -2.20759169080103 0.0156641443313548 no 3271 0.0136363744474152 4727 1068044
SGTC_951 1171-0579 82.7 µM -2.21272365492348 0.0154579162740071 no 3272 0.0134583517607797 4667 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_490 phenamil 164 µM -2.23407172944998 0.0146248695924822 no 3273 0.0127391769006705 4750 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1323 1348-1351 11.2 µM -2.23881638101928 0.0144450617800133 no 3274 0.012583932990911 4720 6989654
SGTC_589 1227-0070 34.1 µM -2.24019195600232 0.0143932888757886 no 3275 0.0125392318325604 4750 2841384
SGTC_299 1273-0059 1.44 µM -2.24614352574064 0.0141711249562498 no 3276 0.0123474080894616 4509 2848077
SGTC_440 fluspirilene 35.1 µM -2.24789477551618 0.0141063184025111 no 3277 0.0122914502006665 4720 3396 An atypical antipsychotic.
SGTC_357 1325-0123 420 µM -2.24801136302898 0.0141020130597579 no 3278 0.0122877326793179 4725 1098503
SGTC_497 capsazepine 133 µM -2.26099456032122 0.0136296000342468 no 3279 0.0118797969548061 4694 2733484 A calcium channel blocker.
SGTC_3306 9127676 59.7925 µM -2.26326961392521 0.0135482405887868 no 3280 0.0118095371085775 4694 41905287
SGTC_304 1310-0298 97 µM -2.26580217556779 0.0134581656298965 no 3281 0.011731749065055 4512 1550234
SGTC_3100 9120536 49.47 µM -2.26986162555352 0.0133148628040236 no 3282 0.0116079900411954 4687 16421196
SGTC_959 1222-0044 107 µM -2.27327012737272 0.0131955589033947 no 3283 0.0115049532789519 4737 6083612
SGTC_3111 9122088 49.47 µM -2.27524893576782 0.0131267215787672 no 3284 0.0114455003992566 4706 16876704
SGTC_3200 9114385 49.47 µM -2.2773484469319 0.0130540248661415 no 3285 0.0113827130137052 4690 17018030 YLR208W SEC13
SGTC_1620 st003704 16.5 µM -2.28178988020485 0.0129013838546632 no 3286 0.011250874269262 4733 2834414
SGTC_725 1497-0963 19 µM -2.28399462393005 0.0128261872691022 no 3287 0.0111859234498389 4764 3549977
SGTC_158 k038-0087 26.446 µM -2.29153503902983 0.0125718669058079 no 3288 0.0109662438660191 4674 X158
SGTC_1907 st060210 83.7 µM -2.29611700023969 0.0124194699944848 no 3289 0.0108345962617886 4728 688793
SGTC_3259 9138485 49.47 µM -2.30144545956466 0.0122442589264063 no 3290 0.0106832324358628 4712 17646153
SGTC_2823 7987624 58.44 µM -2.30406046593951 0.0121590582813725 no 3291 0.0106096247900762 4672 2239440
SGTC_2716 st080858 38.6235 µM -2.31233940241941 0.0118926986905962 no 3292 0.0103794934584806 4729 5296050
SGTC_3199 9111318 49.47 µM -2.3190744056122 0.01167976058858 no 3293 0.0101955011339591 4665 8548020
SGTC_746 1095-0025 46.6 µM -2.31946560917097 0.0116674943989599 no 3294 0.0101849018881731 4746 6749286
SGTC_674 0498-0004 451 µM -2.33756516781154 0.0111120770104907 no 3295 0.00970490832239529 4726 4231473
SGTC_312 4092-0653 6.84 µM -2.36783594729605 0.010234476051819 no 3296 0.00894623384495032 4665 1148278
SGTC_261 5-fluorouridine 15.376 µM -2.39283477242802 0.00955591663165062 no 3297 0.00835938407774342 4761 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_892 0929-0076 29 µM -2.39526140708736 0.00949219206158618 no 3298 0.008304259803818 4751 5751038
SGTC_151 3013-0144 2.285 µM -2.3991630157844 0.00939051287165569 no 3299 0.00821629862937514 4545 906558 YHR107C CDC12
SGTC_937 3122-0005 46.7 µM -2.39964188486982 0.00937809902055398 no 3300 0.00820555919196665 4733 759535
SGTC_1036 k216-0215 33.5 µM -2.42301539789433 0.00878937257688406 no 3301 0.00769613712285377 4717 622330
SGTC_3060 1327-0027 12.5 µM -2.4431299158387 0.00830892970695573 no 3302 0.00728024735460736 4704 16000455 YPR107C YTH1
SGTC_2382 9035899 200 µM -2.44322664373575 0.00830667617841985 no 3303 0.00727829623519228 4749 6462679
SGTC_511 blebbistatin 171 µM -2.45403279319837 0.00805827378132736 no 3304 0.00706320491772069 4757 3476986 A myosin inhibitor.
SGTC_1604 st002052 72.4 µM -2.46219984721917 0.00787489233204394 no 3305 0.00690438497951575 4771 6254834 YHR062C RPP1
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.48001101583795 0.0074876470409362 no 3306 0.00656891619011427 4749 6708561
SGTC_950 1165-0508 94.1 µM -2.48535779909596 0.00737472038980738 no 3307 0.00647106409716407 4738 6148369
SGTC_3139 9095020 49.47 µM -2.4931546567908 0.00721273760240233 no 3308 0.00633068418344681 4714 25236292
SGTC_156 3474-0145 5.642 µM -2.53741901081379 0.00635126271107677 no 3309 0.00558366019328627 4725 2265471
SGTC_1132 3456-3614 2.5 µM -2.54413275440893 0.00622888194699566 no 3310 0.00547747202878858 4728 3125502
SGTC_955 1216-0110 33 µM -2.54545351663598 0.00620505389471725 no 3311 0.00545679465379232 4741 3619719
SGTC_493 zm226600 134 µM -2.54707362724308 0.00617593553364526 no 3312 0.00543152554433982 4762 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2380 9035439 200 µM -2.55100109948485 0.00610584860049293 no 3313 0.0053706993476563 4768 6462575
SGTC_3105 9121040 49.47 µM -2.56679154032237 0.00583112475261839 no 3314 0.00513221493770726 4767 41448907
SGTC_2131 toluylene red 5.2905 µM -2.58488150636959 0.00552991788108326 no 3315 0.00487062344411989 4738 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2896 9052656 71.43 µM -2.58501307609002 0.00552777878013122 no 3316 0.00486876521838549 4446 6469436
SGTC_798 1287-0182 476 µM -2.58725489249141 0.00549144344582523 no 3317 0.00483719987232158 4778 1649755
SGTC_2695 st077686 51.995 µM -2.62151007438006 0.00496203770021985 no 3318 0.00437705874710418 4743 2876092
SGTC_895 0964-0006 13.7 µM -2.6260618716593 0.00489522666674672 no 3319 0.00431895573122995 4764 6738897
SGTC_1837 st055472 66.5 µM -2.63793744507262 0.00472467660204401 no 3320 0.00417059834844814 4776 676091
SGTC_54 0159-0055 9 µM -2.64291451721287 0.00465478905300428 no 3321 0.00410978921352888 4758 3319099
SGTC_2827 7993847 71.43 µM -2.64447993198874 0.00463299913750765 no 3322 0.0040908279019412 4764 2985692
SGTC_2597 laccaic acid a 100 µM -2.6618172150074 0.00439768854398527 no 3323 0.00388600351282551 4746 5491415 A textile dye.
SGTC_2379 9035213 200 µM -2.66278621797517 0.00438485752083813 no 3324 0.00387483158525704 4761 646551
SGTC_676 falcarinol 140 µM -2.67842829442183 0.00418231139050293 no 3325 0.00369842840131228 4766 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1129 3453-1384 223 µM -2.68426498336202 0.00410890418829797 no 3326 0.00363447342718869 4739 1084452
SGTC_657 3534-0529 86.7 µM -2.69379666737594 0.0039915019818718 no 3327 0.00353216230875969 4784 1049549
SGTC_3152 9099253 49.47 µM -2.7318379886805 0.00355229702107468 no 3328 0.0031491051622437 4651 25236131
SGTC_2402 5553605 200 µM -2.83762227759009 0.00254985129731863 no 3329 0.00227254669542296 4775 6758546
SGTC_2349 9023730 187.07 µM -2.84120982552804 0.00252085839507173 no 3330 0.00224713657034694 4775 4126287
SGTC_453 enantio-paf c16 10 µM -2.88760586861409 0.00217184454088783 no 3331 0.00194092973096605 4388 13871343 A lipid and platelet activating factor
SGTC_1035 k081-0041 55.2 µM -2.904042265173 0.00205912082966632 no 3332 0.00184189213392405 4790 731709
SGTC_3144 9087057 49.47 µM -2.90909186863547 0.00202557151921395 no 3333 0.0018124016297347 4756 17249618
SGTC_3288 9119690 36.221 µM -2.92181237827784 0.001943245167403 no 3334 0.00174000553258296 4786 17595618 YKL019W RAM2
SGTC_165 k038-0023 64.381 µM -2.96396405218657 0.00169170033395863 no 3335 0.00151851881356276 4771 46368543
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.99532037215889 0.00152421930445233 no 3336 0.00137078361902224 4785 803109
SGTC_3303 9125618 40.5795 µM -3.01383721784022 0.00143256348996391 no 3337 0.00128983088510339 4776 22695467
SGTC_2740 felodipine 17.08 µM -3.0310068732853 0.00135210119743425 no 3338 0.00121869849690791 4797 3333 L-type calcium channel blocker
SGTC_2397 5161689 200 µM -3.0326847949353 0.00134446366992904 no 3339 0.00121194318570512 4786 2259942
SGTC_466 geldanamycin 89.2 µM -3.07790530235869 0.0011529093676523 no 3340 0.0010423057380315 4804 5288382 HSP90 inhibitor.
SGTC_1386 3228-0095 33.8 µM -3.15678332837158 0.000877533778107701 yes 3341 0.000797599152463085 4789 870181
SGTC_350 k064-0020 19.8 µM -3.25644054019747 0.000616161153126012 yes 3342 0.000564092786273449 4790 2790705
SGTC_1718 roemerine 11.9335 µM -3.30103313284789 0.000524319984648343 yes 3343 0.000481647530403012 4604 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3170 9103054 49.47 µM -3.38139511577354 0.000390039475693008 yes 3344 0.000360593795716182 4799 16432970
SGTC_3116 9124943 49.47 µM -3.40584451889326 0.000356012163186031 yes 3345 0.000329798660327961 4807 41905195 YPL160W CDC60
SGTC_2567 aureobasidin a 60 nM -3.49591493744774 0.000253041340304125 yes 3346 0.000236219639729826 4788 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_930 2810-3379 265 µM -3.54557893681418 0.00020889781393539 yes 3347 0.000195875817333295 4797 1015764
SGTC_310 1273-0058 1.06 µM -3.57379675002921 0.000187134147553993 yes 3348 0.000175921039579714 4580 2734232
SGTC_2179 6298986 200 µM -3.77295067748989 8.41584702104303e-05 yes 3349 8.06640950340724e-05 4799 738374
SGTC_2865 9030313 51.95 µM -3.92549304290884 4.4421115561615e-05 yes 3350 4.3276135882004e-05 4802 42562754
SGTC_1707 st032323 6.317 µM -4.26243430128265 9.96640893151484e-06 yes 3351 1.01105979728983e-05 4791 3132057 YMR211W DML1
SGTC_3186 9110464 49.47 µM -4.28484116791676 8.98688597363837e-06 yes 3352 9.14348931251365e-06 4810 17018021
SGTC_369 0957-0393 4.5 µM -4.35028943850067 6.62383730921665e-06 yes 3353 6.79789767481901e-06 4807 6997992
SGTC_1934 st074720 32.6 µM -5.61146710810373 7.89728742012677e-09 yes 3354 1.00309212230001e-08 4806 17250992
SGTC_910 3454-3003 490 µM -5.61541636661989 7.71278173690955e-09 yes 3355 9.80447422664999e-09 4804 820824
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -8.21846047451117 3.93496246113171e-17 yes 3356 1.03066076623148e-16 4809 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W