SGTCid condition conc unit VIK1|YPL253C.score VIK1|YPL253C.strain.pval VIK1|YPL253C.strain.significant VIK1|YPL253C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1570 verbenone 133 µM 6.29238931032507 2.58788687533786e-10 yes 1 1.56308119872588e-10 3 29025 A natural terpanoid with antifungal properties. SGTC_1877 wortmannin 25 µM 5.24226814346399 1.13149486157403e-07 yes 2 7.93073192366939e-08 61 312145 A covalent inhibitor of PI 3-kinase. SGTC_1722 st034304 3.6505 µM 4.90540833135266 6.37664772702073e-07 yes 3 4.66165880288326e-07 12 4036148 YLR033W RSC58 SGTC_1237 0330-0133 46.1 µM 4.41390468139537 6.5618689458055e-06 yes 4 5.07613361466904e-06 17 X1237 YHR072W ERG7 SGTC_754 3474-0146 171 µM 4.39968264065627 6.99613173933836e-06 yes 5 5.42046516314929e-06 14 24762078 SGTC_114 0364-0001 490.298 µM 4.21769846715319 1.56215764476354e-05 yes 6 1.23404279294132e-05 44 4003655 SGTC_1523 st012844 44.7 µM 4.05951476367841 3.06240489645871e-05 yes 7 2.4587399410464e-05 16 4274103 SGTC_275 trichlorophene 5.69 µM 3.91043557161744 5.65352508386326e-05 yes 8 4.60649165163187e-05 231 62616 SGTC_528 3492-0019 172 µM 3.89552258324131 6.00427972702108e-05 yes 9 4.89936156149265e-05 225 2869262 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 3.80359170587559 8.66229888021478e-05 yes 10 7.13065820373121e-05 79 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1911 st060208 74.3 µM 3.70341883340672 0.000127999362218251 yes 11 0.000106356629962565 43 688783 SGTC_3324 9138759 60.749 µM 3.68952757990402 0.000135022198987023 yes 12 0.000112335435936498 25 45595710 SGTC_2640 pentamidine 10.38 µM 3.60728379951667 0.000184570237869406 yes 13 0.000154709585026188 43 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2413 inermin 26.06 µM 3.59270079710724 0.000194962237684422 yes 14 0.000163634145478442 68 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3069 9117009 49.47 µM 3.55671428753455 0.00022299248594709 yes 15 0.000187761091641197 13 41904981 SGTC_226 1,3-diallylurea 8.28947 mM 3.54886317387819 0.000229588056693343 yes 16 0.000193449031401177 16 74537 YKL182W FAS1 SGTC_997 3996-0078 137 µM 3.53332391035253 0.000243182333083039 yes 17 0.000205184679502709 39 735687 SGTC_951 1171-0579 82.7 µM 3.46827959789592 0.000308644207932519 yes 18 0.00026190099879278 109 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2476 5806916 10.51 µM 3.43729701006712 0.000345284600448088 yes 19 0.000293775467878364 28 2870194 SGTC_761 k216-0224 480 µM 3.43605748980985 0.000346831354321881 yes 20 0.000295122854112914 41 1340404 SGTC_785 1270-0111 65.3 µM 3.37309692295564 0.000434422440967672 yes 21 0.00037163891925767 50 6741994 SGTC_1513 0337-0559 19 µM 3.37092344741608 0.000437784152684341 yes 22 0.00037458336312593 32 775073 SGTC_1636 st007707 68.9 µM 3.33889471956701 0.000490202742830264 yes 23 0.00042056218057766 70 403051 SGTC_2109 5483026 200 µM 3.31322069714348 0.000536354706920377 yes 24 0.000461140861586161 56 759335 SGTC_1672 st016598 6.51 µM 3.31131601394822 0.000539933937156176 yes 25 0.000464291399222485 99 4665860 YNL267W PIK1 SGTC_2873 9040596 71.43 µM 3.30704255365805 0.000548045048183166 yes 26 0.000471432839123832 77 6463863 SGTC_828 2074-0507 139 µM 3.28810550331353 0.000585362040637845 yes 27 0.000504320165913416 45 X828 SGTC_2488 5268135 45.7 µM 3.24862249704866 0.000670832392055474 yes 28 0.000579826327028483 82 1270356 YLR208W SEC13 SGTC_150 3970-0969 77.2 µM 3.2377695465978 0.000696266480372296 yes 29 0.000602340391798145 101 6615640 SGTC_1006 4099-6547 255 µM 3.19539874326883 0.000804311665545944 yes 30 0.00069818885829536 55 3146833 SGTC_633 0437-0093 97.7 µM 3.15891271829665 0.000909499742650748 yes 31 0.000791794545593388 38 2831118 SGTC_527 4476-4215 268 µM 3.15594900434495 0.000918576439175059 yes 32 0.000799884138438656 73 4418754 SGTC_1527 coumarin 137 µM 3.1534531954141 0.000926284604837358 yes 33 0.000806755501208512 57 323 A hepatotoxic, DNA x-linker. SGTC_831 k061-1017 217 µM 3.14782648848617 0.000943880861248428 yes 34 0.000822446499180334 114 1240153 SGTC_2400 5203494 178.7 µM 3.14213766758403 0.000961983031645719 yes 35 0.000838595781380944 48 6777674 SGTC_993 3909-8757 62.7 µM 3.13745926491685 0.000977108286199178 yes 36 0.000852094764542721 58 4288324 YLR208W SEC13 SGTC_3114 9122766 49.47 µM 3.13689205512654 0.000978956837934108 yes 37 0.000853744896502348 54 17176985 SGTC_249 wiskostatin 11.211 µM 3.10772771441181 0.00107844496324805 no 38 0.000942658399137065 41 2775510 A n-wasp and actin depolymerizer. SGTC_991 3996-0057 64.7 µM 3.0946161374906 0.00112612399972744 no 39 0.000985338824285779 45 715343 SGTC_1278 0874-0585 172 µM 3.0881054193535 0.001150510365111 no 40 0.00100718500018808 48 766306 SGTC_2368 9071271 200 µM 3.08440391040155 0.00116458937129918 no 41 0.00101980241825549 77 27209959 SGTC_1224 0823-0416 294 µM 3.07562497063664 0.00119861390815851 no 42 0.00105030938774696 48 3598164 SGTC_1041 0206-0046 107 µM 3.0441175042212 0.00132835656265363 no 43 0.00116681986116797 69 50494 SGTC_336 4111-0029 111 µM 3.03580370649157 0.00136466878008853 no 44 0.00119947743342739 25 3131175 SGTC_1948 st076329 66.6 µM 3.02449785579975 0.00141550501121742 no 45 0.00124523118521631 72 24208413 SGTC_2711 st079103 59.1 µM 3.02420970822769 0.00141682296105555 no 46 0.00124641788521846 30 54693780 SGTC_228 caffeine 993.056 µM 2.99645954376857 0.00154912593096754 no 47 0.00136567238842304 35 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1054 3429-0080 167 µM 2.9878202628712 0.00159255798225776 no 48 0.00140487370088878 65 1162877 SGTC_334 1502-1024 68.5 µM 2.9810332788716 0.00162745324530928 no 49 0.00143638786206851 47 3296216 SGTC_531 3788-1495 174 µM 2.96921123712803 0.00168990373684104 no 50 0.00149282638605072 75 2896655 SGTC_268 camptothecin 39.6153 µM 2.93866268891293 0.00186151077898019 no 51 0.0016481580334976 149 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_857 0438-0306 1.35 µM 2.93223471131603 0.00189957839728247 no 52 0.00168266151686758 46 4686136 SGTC_2370 9071495 200 µM 2.91740834464744 0.00199009448649134 no 53 0.00176476681771785 82 21791103 SGTC_624 k048-0052 28 µM 2.91689981013216 0.00199326746693912 no 54 0.00176764655964627 62 6835531 SGTC_1194 1488-0194 225 µM 2.91513075518501 0.00200434122867656 no 55 0.00177769774562777 86 1391452 SGTC_2671 danthron 100 µM 2.90797155777629 0.00204972835513744 no 56 0.00181890711021296 91 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_894 0960-0238 55.9 µM 2.90249295555879 0.00208508881398275 no 57 0.00185102742909688 45 6741907 YDL195W SEC31 SGTC_576 1073-0113 22.7 µM 2.85823613573943 0.00239166103081082 no 58 0.00213001622131556 164 5439563 SGTC_1076 itraconazole 331 nM 2.85593854105999 0.00240863796278036 no 59 0.00214549093127467 80 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1575 cyproterone acetate 48 µM 2.85575744746084 0.00240998068873091 no 60 0.00214671495260834 77 9880 An androgen receptor antagonist and liver toxin. SGTC_1119 parthenolide 318.541 nM 2.83865502239666 0.00253988176500543 no 61 0.00226520535327722 124 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_368 fentichlor 4.58 µM 2.76302572725275 0.00319350508652179 no 62 0.00286341261371079 88 7329 A pesticide. SGTC_580 1123-0028 41 µM 2.75685098399957 0.00325303665168815 no 63 0.00291804706708871 118 1677248 YPR107C YTH1 SGTC_2453 5731132 22.18 µM 2.7498706963445 0.00332153513123566 no 64 0.00298093927500301 97 1362040 SGTC_2749 bexarotene 57.39 µM 2.7450456342284 0.00336963925623243 no 65 0.00302512419355716 95 82146 An retinoic acid receptor inhibitor. SGTC_819 1013-0258 27.7 µM 2.73976315763745 0.00342302087613359 no 66 0.00307417361697977 100 5753198 SGTC_1891 st059073 26.2 µM 2.73425794039132 0.00347946080811662 no 67 0.00312605229113016 88 688754 SGTC_2065 5221596 34.26 µM 2.73161254628337 0.00350687778344272 no 68 0.00315126053718092 79 788581 SGTC_801 0866-0028 10.1 µM 2.72653145341176 0.00356008321972524 no 69 0.00320019260975599 115 6849771 SGTC_2657 nystatin 74.44 µM 2.72465753166739 0.003579887725462 no 70 0.00321841076143157 67 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1913 st060213 96.1 µM 2.7123307805699 0.00371264601310746 no 71 0.00334059422942358 129 688959 SGTC_2128 5255449 168.493 µM 2.69507482620049 0.00390590878490752 no 72 0.00351864128487034 108 736008 SGTC_3159 9100096 49.47 µM 2.69303987824418 0.00392928390948069 no 73 0.00354018998640836 91 25236875 SGTC_2361 9034121 116 µM 2.67108024889411 0.00418961871451233 no 74 0.00378037843757534 84 6496917 SGTC_2070 5230947 200 µM 2.66245268784112 0.0042960505046172 no 75 0.0038786737023376 82 2835538 SGTC_722 3534-0461 190 µM 2.65416031628722 0.00440061866436948 no 76 0.00397530217058338 126 658262 SGTC_1798 st045719 60.953 µM 2.64569239921881 0.00450974151300161 no 77 0.00407619556383608 60 3980186 SGTC_2707 st078556 66.6 µM 2.6412069147523 0.00456851773392238 no 78 0.00413056244845655 65 17250899 SGTC_419 nsc-638432 893 µM 2.63926193446207 0.00459421592692933 no 79 0.00415433782918067 78 368090 SGTC_1256 0570-0116 285 µM 2.63724819132517 0.00462095852141628 no 80 0.00417908269712722 95 410638 SGTC_1780 st038448 24.544 µM 2.62909372263366 0.00473067596120829 no 81 0.00428063811352542 102 728868 YDL195W SEC31 SGTC_2393 9031399 185.94 µM 2.62547779916782 0.00478006702325567 no 82 0.0043263725708607 123 1526623 YDL150W RPC53 SGTC_1238 0333-0287 48.8 µM 2.61321687269065 0.00495098363430537 no 83 0.0044847182871792 110 7226 SGTC_1002 4049-0206 172 µM 2.60751017364602 0.00503237553787302 no 84 0.00456016801133018 141 4662749 SGTC_2156 5649887 115 µM 2.58749253273899 0.005327378980871 no 85 0.00483386455414147 109 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2382 9035899 200 µM 2.57770685765572 0.00547711203300698 no 86 0.00497291660995946 82 6462679 SGTC_1105 epirubicin 18.1 µM 2.55956181987172 0.0057646780547557 no 87 0.00524021069042935 92 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2955 9076254 12.21 µM 2.55939323681087 0.00576741145725179 no 88 0.00524275288429637 78 16459619 SGTC_1118 chelidonine 707.474 nM 2.55284031625294 0.00587455560609112 no 89 0.00534242350893475 105 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_712 r015-0009 80.6 µM 2.54782495971239 0.00595774863448307 no 90 0.00541984223933121 90 6813872 YLR060W FRS1 SGTC_1008 4106-0037 6 µM 2.53996759077834 0.00609018504397905 no 91 0.00554313707192448 86 2905394 SGTC_247 mechlorethamine 29.705 µM 2.52591866414937 0.0063334943350909 no 92 0.00576980970611913 82 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2008 4012253 172 µM 2.52245202526183 0.00639483994933691 no 93 0.00582699227502232 131 603940 SGTC_1707 st032323 6.317 µM 2.51915444248748 0.00645368133390623 no 94 0.00588185227073118 169 3132057 YMR211W DML1 SGTC_2634 4'-methoxyflavone 100 µM 2.48472415658063 0.00709724690866063 no 95 0.00648259271166185 128 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1220 1838-0075 193 µM 2.47857165327303 0.00721803094499756 no 96 0.00659548066470908 105 5529645 SGTC_2444 5485484 36.41 µM 2.45942488888794 0.00760559158245186 no 97 0.00695799067619689 152 6790631 SGTC_1880 MG-132 525 µM 2.44523563114589 0.0079045118007754 no 98 0.00723787660855901 97 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_367 0335-0881 7.1 µM 2.4361922917369 0.00810037247991181 no 99 0.00742139590622803 202 23828853 SGTC_859 0439-0102 54.6 µM 2.43474893823648 0.00813202418760236 no 100 0.00745106268445279 119 610143 SGTC_1720 st037298 9.481 µM 2.43037694281956 0.00822856304902897 no 101 0.00754156350833448 148 597396 SGTC_8 0354-0001 70 µM 2.41672819446614 0.00853645080803353 no 102 0.00783035324523156 223 4993152 SGTC_1389 3405-0187 19 µM 2.41644471291599 0.00854295130964093 no 103 0.00783645309096423 113 799890 SGTC_2564 betulinic acid 100 µM 2.40871892645367 0.00872179096393542 no 104 0.00800431083198752 166 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2407 paclitaxel 400 µM 2.40572598789691 0.00879194994017959 no 105 0.00807018288408101 157 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_892 0929-0076 29 µM 2.39947339634859 0.00894011816874409 no 106 0.0082093364209264 185 5751038 SGTC_1618 st003135 44.5 µM 2.38680078495909 0.0092471461734494 no 107 0.00849784905878562 100 1270615 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.38316846504769 0.00933683338574123 no 108 0.00858216871692642 138 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1597 7-benzyloxygramine 47.5 µM 2.38274315328326 0.00934738455580337 no 109 0.00859208962811932 325 260807 SGTC_687 k029-0044 34.9 µM 2.38091844878041 0.00939277044266806 no 110 0.00863476732529479 119 5829338 SGTC_351 caspofungin 25 nM 2.37510679223133 0.00953861091831696 no 111 0.00877193676332486 266 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_440 fluspirilene 35.1 µM 2.35472478663328 0.0100658470765842 no 112 0.00926821430465938 155 3396 An atypical antipsychotic. SGTC_2692 st077426 47.7 µM 2.35320676647589 0.0101061134211909 no 113 0.00930614067665022 138 25238571 SGTC_1660 st012960 28.1 µM 2.34378491691528 0.0103591905096954 no 114 0.00954458801954176 159 24207266 SGTC_1709 st033179 39.1045 µM 2.34109073730901 0.0104325663131377 no 115 0.0096137467539141 138 573381 SGTC_72 0744-0168 198.391 µM 2.33666247527209 0.0105541540619192 no 116 0.00972837058112046 145 677577 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.33519232865237 0.0105947922626569 no 117 0.00976668785733629 207 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2912 7964298 10.93 µM 2.33366549502622 0.0106371416472208 no 118 0.00980662209614189 241 2975850 SGTC_3039 9090270 49.47 µM 2.32422741952219 0.0109022099344373 no 119 0.0100566542333345 93 17173750 SGTC_1423 4048-0112 5.59 µM 2.3099302583198 0.0113146918969156 no 120 0.0104460077764709 151 X1423 SGTC_2489 cantharidin 73.42 µM 2.29271678566321 0.0118292494070394 no 121 0.0109321577571715 214 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_777 1315-0167 517 µM 2.28967706416011 0.0119221938129342 no 122 0.0110200219718585 145 4221767 SGTC_1444 4112-3581 28 µM 2.28214400256831 0.0121552639275778 no 123 0.0112404199267773 137 2877249 SGTC_1708 st033234 31.827 µM 2.26595349664647 0.012669592091607 no 124 0.0117271153255301 136 674664 SGTC_1982 st072467 71.9 µM 2.2590967882147 0.0128930248652947 no 125 0.0119386824477159 206 3163533 SGTC_2792 7535235 81.82 µM 2.25044960267717 0.013179654302474 no 126 0.0122102096385807 165 1281891 SGTC_192 3455-0609 60.9 µM 2.2391916349944 0.0135610620365801 no 127 0.012571724946894 138 3769639 SGTC_942 3253-1115 227 µM 2.23228222699365 0.0137998324648612 no 128 0.0127981578909656 165 46497897 SGTC_1750 st081859 2.357 µM 2.22693392024441 0.0139871368836535 no 129 0.0129758452174962 394 5291695 SGTC_2067 5224629 34.075 µM 2.22422819971429 0.0140827265831686 no 130 0.013066547332085 168 2835000 SGTC_3082 9117008 49.47 µM 2.22399842090448 0.014090870253324 no 131 0.013074275243366 146 41448529 SGTC_794 k038-0031 316 µM 2.19054620918784 0.0153205920664619 no 132 0.0142423236872553 276 6624242 SGTC_2379 9035213 200 µM 2.17472522002363 0.0159335798660343 no 133 0.0148253569009534 167 646551 SGTC_1917 st066507 28.5 µM 2.16805391148991 0.0161982964584659 no 134 0.0150772924593985 224 3156428 SGTC_854 0422-0053 192 µM 2.16471408400274 0.0163322296693928 no 135 0.0152047939179979 154 3596728 SGTC_2011 4012611 177 µM 2.16154827660273 0.0164600587843219 no 136 0.0153265059859221 204 2049887 SGTC_959 1222-0044 107 µM 2.15213825173144 0.0168450855733948 no 137 0.0156932336024821 190 6083612 SGTC_464 bw-b 70c 158 µM 2.14113366448239 0.0173051029951705 no 138 0.0161316302951533 222 5353454 SGTC_500 h-89 112 µM 2.1394555951086 0.0173761846585945 no 139 0.0161993942602284 196 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2914 7968218 45.32 µM 2.1363402334808 0.0175088101534346 no 140 0.0163258458672301 117 2977111 SGTC_2808 7946468 45.46 µM 2.13547190682788 0.017545929736937 no 141 0.0163612412782865 215 2970879 SGTC_2019 4016004 108 µM 2.12858532917517 0.0178427060393429 no 142 0.0166442916821444 186 45595336 SGTC_666 0272-0154 136 µM 2.11938552414245 0.0182458430700806 no 143 0.0170289495844355 249 6870312 SGTC_1690 st023502 41.2 µM 2.11907127902845 0.018259749326419 no 144 0.0170422217665079 154 24207482 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.11283109251599 0.0185377715684408 no 145 0.017307613705677 267 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_982 1491-0518 27.5 µM 2.10657875545805 0.0188199419396231 no 146 0.0175770549250326 166 3091256 SGTC_2845 9003024 42.97 µM 2.09383327838487 0.0194064811162648 no 147 0.0181374172844765 249 2990173 SGTC_1016 4226-1401 38 µM 2.09088813771469 0.0195442021801177 no 148 0.0182690463532778 199 2901613 SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.07957286412342 0.0200810748541658 no 149 0.0187823640497452 225 1273210 SGTC_1521 st012942 49.4 µM 2.07568869204578 0.020268226999425 no 150 0.0189613762317234 223 24207259 SGTC_113 0099-0221 2.5 µM 2.07203064225693 0.0204458338538387 no 151 0.0191312918222646 191 89219 SGTC_711 k292-0785 179 µM 2.06654047001475 0.0207148686312799 no 152 0.019388737603604 192 4146315 SGTC_3086 9117350 49.47 µM 2.0646048595847 0.020810431360849 no 153 0.0194802015424287 106 2679265 SGTC_1157 4092-0394 27.6 µM 2.05961913742977 0.0210583010584902 no 154 0.0197174826213882 235 3659885 SGTC_851 0394-0702 453 µM 2.05848011410026 0.0211152778586525 no 155 0.0197720341321526 181 762646 SGTC_2667 digitoxin 100 µM 2.05781223810698 0.0211487473076589 no 156 0.019804080415208 101 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2862 9027634 71.43 µM 2.05622098303817 0.021228671186887 no 157 0.0198806103122062 202 5012562 SGTC_1784 st039334 36.3 µM 2.04923516522743 0.0215825765617331 no 158 0.0202195625053164 210 3496984 SGTC_1610 st001799 48.1 µM 2.04767338715645 0.0216623754280942 no 159 0.020296006591273 158 621897 SGTC_1871 st057448 67.3 µM 2.04278382657179 0.0219138206808549 no 160 0.0205369211466926 224 691747 SGTC_2780 5215298 71.43 µM 2.03596123937236 0.0222687868254807 no 161 0.0208771237945691 248 2834131 SGTC_921 1561-0023 372 µM 2.03447781738402 0.0223466051617125 no 162 0.0209517214697309 201 24050882 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.03244882028736 0.0224534149881673 no 163 0.0210541200019731 202 165521 SGTC_416 estradiol valerate 100 µM 2.01944415880952 0.0231482733817635 no 164 0.0217205378684041 210 13791 A steroid. SGTC_2040 5100729 123 µM 2.0138819120033 0.0234509534523254 no 165 0.0220109665165304 239 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_796 1234-0020 70.7 µM 2.01241591089018 0.0235312808679297 no 166 0.0220880563270128 225 46495034 SGTC_736 0958-0254 92.6 µM 1.99915227966507 0.024268617555836 no 167 0.0227959400043586 246 6812352 SGTC_3080 9117754 49.47 µM 1.9980888742879 0.0243285642065927 no 168 0.0228535128576836 236 9550191 SGTC_1700 st030840 7.9285 µM 1.99688721651963 0.0243964540503008 no 169 0.0229187180926697 218 5499307 SGTC_2973 9094665 17.96 µM 1.99056951751529 0.0247560054805584 no 170 0.0232641171210979 274 25237061 YIL048W NEO1 SGTC_3004 9076122 71.4286 µM 1.98868083355992 0.0248643530134438 no 171 0.0233682214212398 227 44782551 SGTC_2223 6903751 107.57 µM 1.98439679594141 0.0251115887399405 no 172 0.0236058114692933 153 5598863 SGTC_362 0310-0100 9.03 µM 1.97731135761709 0.0255250168026474 no 173 0.0240032233249608 254 790235 SGTC_2890 9046729 58.44 µM 1.9744711546575 0.0256923325370294 no 174 0.0241640971091059 196 903329 SGTC_3124 9127567 49.47 µM 1.96922690807392 0.0260036826648769 no 175 0.0244635201245722 195 17592030 SGTC_2358 9037157 4 µM 1.96561704247166 0.0262198287901857 no 176 0.0246714319830259 238 2388925 SGTC_2686 alizarin 95.37 µM 1.95898889493738 0.026620610465719 no 177 0.0250570436627239 222 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_575 k072-0246 11.9 µM 1.95441035107485 0.0269004376100678 no 178 0.0253263537678533 235 6796779 SGTC_91 0417-1751 58.384 µM 1.95257769259089 0.0270131304103644 no 179 0.0254348282903118 311 6795624 SGTC_3001 9076041 71.4286 µM 1.94957867501855 0.0271983941490259 no 180 0.0256131785766151 206 16004211 SGTC_1935 st074532 41.6 µM 1.94838084238443 0.0272726856927108 no 181 0.0256847051937964 288 2829742 SGTC_867 0518-0118 155 µM 1.94260076359877 0.0276335587151813 no 182 0.0260322072922188 232 6848158 SGTC_1043 0916-0009 19.3 µM 1.93802566758095 0.0279220140557418 no 183 0.0263100455549944 291 3101130 SGTC_3210 9128157 49.47 µM 1.93612700703632 0.0280424569774258 no 184 0.0264260737766847 286 17590849 SGTC_2363 9053361 176 µM 1.9347429001615 0.0281305312037551 no 185 0.0265109265614548 265 6469797 YMR079W SEC14 SGTC_2148 5546263 113.568 µM 1.93467761286589 0.0281346912812813 no 186 0.0265149346202861 232 792097 SGTC_2647 atorvastatin 60.16 µM 1.93036055849282 0.0284109109732227 no 187 0.0267810891749627 224 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1769 st044406 64.4 µM 1.92839013173172 0.0285377334913219 no 188 0.0269033091780012 256 670903 SGTC_1001 4048-4355 44.4 µM 1.92021335177371 0.0290690576104662 no 189 0.027415477898988 232 21824233 SGTC_2308 7584454 197.62 µM 1.91495880156264 0.0294148152288269 no 190 0.0277488789267599 283 893577 SGTC_136 0097-0015 404.482 µM 1.91297705527916 0.0295461009035456 no 191 0.0278754949393465 258 4861337 SGTC_1955 wogonin 32.4 µM 1.91047786730656 0.0297123588651413 no 192 0.0280358567151671 222 5281703 A flavanone. SGTC_24 0417-1663 219 µM 1.90604835413737 0.0300089383256473 no 193 0.0283219661964618 229 4329390 SGTC_1067 clotrimazole 1.36 µM 1.90305289781441 0.0302108881597972 no 194 0.0285168216005744 266 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1426 4048-4480 71.7 µM 1.90152480804243 0.0303143431473901 no 195 0.0286166531241457 224 14224343 SGTC_1276 0871-0068 94.2 µM 1.8991580870372 0.0304751546452989 no 196 0.0287718468222125 223 3414906 SGTC_2524 avocatin b 10.57 µM 1.89812972807026 0.0305452484256111 no 197 0.0288394974620355 202 6710748 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.89727126477547 0.0306038641971495 no 198 0.0288960727275123 253 688801 SGTC_2608 thymoquinone 42.66 µM 1.89573426541683 0.0307090430282354 no 199 0.0289975959616096 221 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_970 1315-0089 19.5 µM 1.89015573208986 0.0310933067585772 no 200 0.0293685675981966 222 6811083 YLR033W RSC58 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.88819636993893 0.0312292131390114 no 201 0.0294997964904922 297 165506 SGTC_3030 9087619 49.47 µM 1.8855330494744 0.0314147353469878 no 202 0.0296789533846043 240 25236973 SGTC_763 3453-1109 128 µM 1.88421263512188 0.0315070504055629 no 203 0.0297681095684291 263 1560353 SGTC_3234 9132280 49.47 µM 1.88273112067856 0.031610895402363 no 204 0.0298684078596795 261 17612295 SGTC_2860 9025725 38.96 µM 1.87580930902335 0.0320998263507929 no 205 0.0303407346341193 216 40546248 SGTC_2523 spermine 47.74 µM 1.87501763049427 0.0321561433371909 no 206 0.0303951490492644 241 1103 A DNA binding polyamine. SGTC_2811 7967822 32.47 µM 1.87377383061615 0.0322447872262435 no 207 0.0304808023997313 256 2232244 SGTC_3278 9139605 49.47 µM 1.87167419518425 0.0323948828689704 no 208 0.0306258458446756 254 7958859 SGTC_377 3970-0964 33.1 µM 1.85930778772039 0.0332906530520732 no 209 0.0314917618824943 365 16481235 SGTC_1732 st034308 51.822 µM 1.85718464432517 0.0334464775689197 no 210 0.0316424444513282 266 830119 SGTC_1417 3966-0327 90.4 µM 1.85685144218864 0.0334709868055521 no 211 0.0316661462939778 285 651118 SGTC_1682 st012968 530 nM 1.85555495494177 0.0335664928134917 no 212 0.0317585096434509 221 24207270 SGTC_3334 9142812 21.919 µM 1.85325802690209 0.033736247191948 no 213 0.0319226920689737 267 45283678 SGTC_2321 7390090 138.78 µM 1.84958764520883 0.0340089724024074 no 214 0.0321865024284945 245 649046 SGTC_1461 k072-0203 53.8 µM 1.84797991436256 0.0341290034661988 no 215 0.0323026242756797 261 5418714 SGTC_330 1488-0319 80.1 µM 1.84327212061338 0.0344824856875831 no 216 0.0326446447663795 250 6846614 SGTC_1799 st045822 46.1415 µM 1.84251524367877 0.0345395950777443 no 217 0.0326999094257122 234 3674992 SGTC_1977 st070720 65.3 µM 1.83943315790333 0.0347729537147131 no 218 0.0329257504354667 229 682188 SGTC_1242 0402-0103 60.1 µM 1.83834770989775 0.0348554455011195 no 219 0.0330055925134799 248 432868 SGTC_56 0957-0365 83.25 µM 1.83673702497166 0.0349781502145095 no 220 0.0331243633074941 302 6752360 SGTC_283 0987-0079 11.7 µM 1.83522713179595 0.0350934981793724 no 221 0.0332360213242952 310 411556 SGTC_1739 st037196 92.5 µM 1.83429279364573 0.0351650329478276 no 222 0.0333052716542941 282 612214 SGTC_1398 3558-0053 112 µM 1.83399016447568 0.0351882284668651 no 223 0.0333277270782803 206 4532369 SGTC_467 ro 31-8220 72.8 µM 1.83131110642886 0.0353941172435786 no 224 0.0335270604251113 341 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2288 7946289 167.31 µM 1.82521134462746 0.0358665777563216 no 225 0.0339845712495799 324 1246052 SGTC_315 k915-0449 187 µM 1.82168195574959 0.0361423001814524 no 226 0.0342516287100458 345 20970215 YNL149C PGA2 SGTC_679 0422-0091 41.4 µM 1.82135016538371 0.0361683092709753 no 227 0.03427682267398 330 627384 YHR062C RPP1 SGTC_2173 5763948 167 µM 1.82002148171465 0.0362726185667145 no 228 0.0343778667897866 273 2867177 SGTC_2976 9009005 19.48 µM 1.81915055029872 0.0363411252038912 no 229 0.034444232342472 265 2993148 SGTC_775 4577-0580 57.3 µM 1.80565835274284 0.0374160019210775 no 230 0.035485860899252 257 2006902 SGTC_2162 5663267 200 µM 1.79945948266419 0.0379184779213702 no 231 0.0359730138062061 248 6456493 SGTC_2831 7999036 19.48 µM 1.79752126660424 0.0380767135711778 no 232 0.0361264525271176 322 2988270 SGTC_830 4076-0286 57.8 µM 1.79720002254898 0.0381029918456072 no 233 0.0361519354863673 473 6866659 SGTC_1760 st045453 10.4495 µM 1.79087811737874 0.0386231505141197 no 234 0.0366564279804424 377 3323419 YIL048W NEO1 SGTC_2221 6807166 181.081 µM 1.78870490366792 0.0388032906916668 no 235 0.0368311764107411 179 674925 SGTC_682 0kpi-0099 17 µM 1.78853921179676 0.0388170531120925 no 236 0.0368445276192034 343 1714895 YML126C ERG13 SGTC_2210 7115885 190.385 µM 1.78832335417751 0.0388349882790355 no 237 0.036861927046023 275 2927039 SGTC_99 0109-0120 622.8 µM 1.78704820786324 0.0389410753200989 no 238 0.0369648486525775 247 759414 SGTC_3236 9132701 49.47 µM 1.78074652392468 0.0394688200241229 no 239 0.0374769345299158 281 24282524 SGTC_1675 st018485 24.5 µM 1.77834640472871 0.0396713456666565 no 240 0.0376734896414124 310 3323024 SGTC_21 0849-0113 22.993 µM 1.77812660573148 0.0396899347951662 no 241 0.0376915318226167 312 1560156 SGTC_2673 kobusone 100 µM 1.77746612534847 0.0397458364285061 no 242 0.0377457897425166 203 6710676 An epoxy ketone and protein crosslinker. SGTC_1506 4226-2149 212 µM 1.77565598032342 0.0398993713858892 no 243 0.0378948185191897 342 991114 SGTC_2277 7947813 106.88 µM 1.77546018233268 0.0399160076570665 no 244 0.0379109672537048 308 1246798 SGTC_1436 4092-1007 8.32 µM 1.77483914474258 0.0399688123551415 no 245 0.0379622254200703 278 2881121 SGTC_358 0075-0058 9.45 µM 1.76962506076493 0.0404143906202552 no 246 0.0383948106106362 402 1069125 SGTC_1630 st005209 31.3 µM 1.76696307144238 0.0406434258403902 no 247 0.0386172065114345 347 3367314 SGTC_3328 9140624 29.0385 µM 1.76088542514297 0.0411702904222589 no 248 0.0391288986323202 302 4904392 SGTC_395 anisomycin 6.25 µM 1.75945365221365 0.0412952117980336 no 249 0.0392502429384002 233 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2366 9070441 60.58 µM 1.7576077225627 0.0414567213435619 no 250 0.0394071392231022 323 6837235 SGTC_333 3486-0131 40.1 µM 1.75589384592115 0.0416071348127437 no 251 0.0395532679886222 288 6744690 SGTC_93 0109-0045 59.227 µM 1.75509737572763 0.0416771850446446 no 252 0.0396213265688896 404 88733 SGTC_565 1418-0001 44.5 µM 1.7542628109609 0.0417506881875048 no 253 0.0396927424853166 348 2862145 SGTC_1866 st057638 64 µM 1.75184329022475 0.041964377699918 no 254 0.0399003790424783 266 688802 SGTC_1713 st033146 12.748 µM 1.74781102277074 0.0423224699632989 no 255 0.0402483779934219 320 674619 SGTC_348 k064-0012 10.7 µM 1.74487153960817 0.0425850704160409 no 256 0.0405036162170541 267 5066323 SGTC_3166 9102297 49.47 µM 1.73878850774627 0.0431326859223919 no 257 0.0410359853987604 337 25237072 SGTC_2433 5607874 27.82 µM 1.7333368847252 0.0436282799200535 no 258 0.0415179042605896 333 2252428 SGTC_1809 st050081 57.6 µM 1.73251487029887 0.0437034044027014 no 259 0.0415909658970446 301 5036894 SGTC_250 brefeldin a 552.239 µM 1.73060191126904 0.0438786351968493 no 260 0.0417613952900425 229 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_845 0330-0138 4.51 µM 1.7266453695842 0.0442428603332563 no 261 0.0421156862616597 300 9039800 SGTC_2946 9065502 71.43 µM 1.7215850938897 0.044712238516915 no 262 0.0425723526638991 184 16489101 SGTC_2349 9023730 187.07 µM 1.72145918008545 0.0447239688958869 no 263 0.0425837666541003 328 4126287 SGTC_183 3914-0051 30.55 µM 1.71321705590591 0.0454972279020036 no 264 0.0433363074860428 312 1596232 SGTC_1983 st071813 46.9 µM 1.70659160328219 0.0461265777965664 no 265 0.0439489934716602 308 11838595 SGTC_1665 st014639 11.4 µM 1.70657484256068 0.0461281787144629 no 266 0.043950552225158 362 981133 YIL048W NEO1 SGTC_1024 4507-0395 26 µM 1.70592939854781 0.0461898629335973 no 267 0.0440106126912243 312 4201836 SGTC_2360 9040895 200 µM 1.69862358503551 0.0468926980697932 no 268 0.0446950648443231 311 4914414 SGTC_2911 7942208 15.64 µM 1.69693053115938 0.047056791604729 no 269 0.0448548975097098 287 1243384 SGTC_1811 st050069 61.5 µM 1.68329428559822 0.0483952854380467 no 270 0.0461590680483943 258 3877702 SGTC_1604 st002052 72.4 µM 1.66823323181386 0.0499088405793262 no 271 0.0476347181821376 342 6254834 YHR062C RPP1 SGTC_3180 9109287 49.47 µM 1.66747135410446 0.0499863972358805 no 272 0.0477103579315411 300 18891271 SGTC_439 amiodarone 34.4 µM 1.66668853322104 0.0500661859154911 no 273 0.0477881770901876 411 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_408 cantharidin 100 µM 1.66274623990245 0.0504695469978803 no 274 0.0481816210011228 383 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1807 st050092 58.9 µM 1.65891119924618 0.0508644146744093 no 275 0.0485668437908654 320 5008496 SGTC_1098 clofazimine 15.1 µM 1.6586534714195 0.0508910390861507 no 276 0.048592820131454 383 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2863 9028737 58.44 µM 1.65677215383911 0.0510857236561937 no 277 0.048782774426528 267 6460917 SGTC_1512 0259-0544 12.2 µM 1.65081098668234 0.0517065204909446 no 278 0.0493885880152491 380 18476 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.64923882018814 0.0518712415557113 no 279 0.0495493589253339 334 6708514 SGTC_3297 9117502 71.43 µM 1.64897796236401 0.0518986127817676 no 280 0.0495760747948385 282 7453720 SGTC_2000 st075254 36.4 µM 1.64754380404569 0.0520493008608233 no 281 0.0497231601495747 288 17234175 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.64686306439305 0.0521209482258932 no 282 0.0497930976403744 359 2333 A French combination drug. SGTC_669 0108-0021 26.2 µM 1.64529711366578 0.052286060811898 no 283 0.0499542773938996 493 17201 SGTC_3233 9132340 49.47 µM 1.63807953244094 0.0530524522767719 no 284 0.0507025520040809 347 17682950 SGTC_1258 0671-0043 57.1 µM 1.63732593571595 0.0531329831322636 no 285 0.0507811922624601 372 4298767 SGTC_975 1335-0046 28.5 µM 1.63275884417694 0.0536231071727119 no 286 0.0512598630017679 386 16486740 SGTC_212 3807-4682 38.772 µM 1.63013759342188 0.0539060240250596 no 287 0.0515362099589442 495 3125501 YBL034C STU1 SGTC_3139 9095020 49.47 µM 1.62799107664589 0.0541385809287208 no 288 0.0517633889431801 232 25236292 SGTC_673 1082-0474 110 µM 1.62397811281487 0.054575480702434 no 289 0.0521902399302545 448 3098046 SGTC_2648 atorvastatin 78.68 µM 1.61419676694209 0.0556520785334184 no 290 0.0532423765272544 320 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_704 1310-0270 142 µM 1.61333913514525 0.0557472687189547 no 291 0.0533354242846964 405 5718033 SGTC_865 0488-0499 301 µM 1.61313016149073 0.0557704825588238 no 292 0.0533581161531751 377 9634651 SGTC_3321 9137793 26.8275 µM 1.60746767879912 0.0564024077989225 no 293 0.0539759070231628 405 4904192 SGTC_2859 9028643 45.46 µM 1.60666694346392 0.0564922224260611 no 294 0.0540637243927452 327 17151580 SGTC_2475 5812728 15.03 µM 1.60625862012566 0.0565380654593521 no 295 0.0541085491004836 392 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2963 9082507 9 µM 1.60560998555382 0.0566109488349192 no 296 0.0541798150392892 352 16459611 SGTC_863 0466-0191 129 µM 1.60522427742712 0.0566543237466374 no 297 0.0542222282687235 433 765160 YPR165W RHO1 SGTC_877 0771-0151 33.1 µM 1.59942153261381 0.0573100377206754 no 298 0.0548634854839155 399 6166523 SGTC_1210 3013-0140 750 nM 1.59854260545262 0.0574098757690606 no 299 0.0549611356850506 358 905973 SGTC_770 0389-1121 67.2 µM 1.59827172802556 0.0574406725241718 no 300 0.0549912582680467 431 6753108 SGTC_557 1315-0110 16.2 µM 1.59759234624496 0.0575179703726088 no 301 0.0550668654544927 378 6833801 SGTC_2167 5876490 200 µM 1.58523973651215 0.0589377260909346 no 302 0.0564559376755585 386 686534 SGTC_3190 9110366 49.47 µM 1.58425995568435 0.0590515045713004 no 303 0.0565672872299087 300 17123768 SGTC_663 1486-0733 13.9 µM 1.58340831962706 0.0591505419606127 no 304 0.0566642139759107 447 722445 YPR165W RHO1 SGTC_1796 st049173 110.4 µM 1.58022762916435 0.0595215790426444 no 305 0.0570273732925462 291 94134 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.57941180979951 0.0596170401597431 no 306 0.0571208151408075 223 6708630 An antioxidant. SGTC_2953 9074162 66.49 µM 1.57746105184571 0.0598457897878834 no 307 0.0573447385769521 321 16451992 SGTC_2502 avocadyne acetate 18.59 µM 1.57505295734959 0.060129115125081 no 308 0.0576221106423999 455 3952079 SGTC_2555 cholic acid 100 µM 1.57228618709658 0.0604559358612488 no 309 0.0579420974989629 362 6708657 Influences liver metabolism. SGTC_2710 st078562 53.7235 µM 1.56875604331155 0.0608749451944525 no 310 0.0583523971804015 354 17250908 SGTC_479 n-linoleoylglycine 10 µM 1.56731310434103 0.0610468667541446 no 311 0.0585207619116361 322 6433346 An anti-infammatory. SGTC_433 pimozide 108 µM 1.55496986261934 0.0625330737977091 no 312 0.0599766235382114 294 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2082 5219693 150 µM 1.5497360815843 0.0631717084062244 no 313 0.0606024370661169 408 2834649 SGTC_2212 7123476 200 µM 1.54965542610026 0.0631815897106451 no 314 0.0606121210154077 290 1085715 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.54771089997471 0.0634201829308211 no 315 0.0608459582995337 461 91467 include heat shock SGTC_2861 9024595 19.48 µM 1.54671019045735 0.0635432429411244 no 316 0.0609665723562596 260 16482810 SGTC_3034 9090421 49.47 µM 1.54575207335264 0.06366123929365 no 317 0.0610822278826011 343 17173761 SGTC_42 0133-0086 60.653 µM 1.54531117747709 0.0637155948094331 no 318 0.0611355065605781 361 162923 Model of phenazepam hydroxylation. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.54329038964399 0.063965188210791 no 319 0.0613801671689261 445 4174840 SGTC_637 1181-0519 7.26 µM 1.54032653778853 0.064332636691201 no 320 0.0617403890959072 528 6252091 YGR060W ERG25 SGTC_767 0929-0023 86 µM 1.53738106895225 0.0646994291193867 no 321 0.0621000097466963 518 1204563 SGTC_697 0508-1955 564 µM 1.53579395433943 0.0648977410458494 no 322 0.0622944614765875 446 6243113 SGTC_2289 7946404 165.07 µM 1.53535724567712 0.0649523910349583 no 323 0.062348049819533 517 1246120 YPR165W RHO1 SGTC_3214 9129694 49.47 µM 1.53458985247741 0.0650485096225126 no 324 0.0624423034097597 379 17158655 SGTC_1409 3909-8004 61.9 µM 1.53140162106131 0.065449028867417 no 325 0.0628350818553172 419 2119279 SGTC_1034 k072-0165 12.7 µM 1.53091327143047 0.0655105459927813 no 326 0.0628954143911044 430 5835461 SGTC_841 0251-0215 91.2 µM 1.52648758662375 0.0660700933374206 no 327 0.0634442397927126 484 3888614 SGTC_3181 9108277 49.47 µM 1.51937764313432 0.0669767595029588 no 328 0.0643337330668444 390 17097298 SGTC_1651 st011928 86.1 µM 1.51877111499426 0.0670545478345049 no 329 0.0644100594856195 388 720198 SGTC_450 aminopyrene 156 nM 1.51763037831166 0.0672010386401059 no 330 0.0645538021042171 430 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2120 5538279 151.968 µM 1.50959535048131 0.0682398981036552 no 331 0.0655733542426571 401 2058197 SGTC_2781 5567276 71.43 µM 1.50468380131978 0.0688809960780189 no 332 0.0662026948251176 429 2853274 SGTC_3242 9133940 49.47 µM 1.50026219364554 0.0694621051078932 no 333 0.0667732492556171 407 17248444 SGTC_505 gw-5074 63.9 µM 1.49921863972888 0.0695998031311657 no 334 0.0669084604905804 437 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2096 5468907 200 µM 1.49818456561821 0.0697364575002348 no 335 0.0670426522747198 402 759785 SGTC_22 0964-0034 14.468 µM 1.49709996456949 0.0698800108963539 no 336 0.0671836244950375 474 138402 SGTC_2996 9066192 71.4286 µM 1.49479644329177 0.0701856498950247 no 337 0.0674837874311263 442 6472854 SGTC_3330 9141424 71.43 µM 1.49347034341675 0.0703620670586592 no 338 0.0676570558154686 464 27261020 SGTC_543 3844-1095 191 µM 1.49263936039193 0.0704727902019798 no 339 0.0677658072079151 450 4230703 SGTC_1147 3809-1045 12.3 µM 1.48972497585844 0.0708621720457794 no 340 0.0681482823676629 430 325925 SGTC_2196 6573537 42.6665 µM 1.48927316321364 0.0709226850215324 no 341 0.0682077258110579 373 2903087 SGTC_2268 7933382 153.85 µM 1.48921927674932 0.0709299048880934 no 342 0.0682148181390535 506 935025 YOR257W CDC31 SGTC_1260 0700-1617 7.75 µM 1.48706443117872 0.0712190803458644 no 343 0.0684988973048201 464 2853078 SGTC_2112 5488546 200 µM 1.48574624204364 0.0713964240746914 no 344 0.0686731271450361 432 600757 SGTC_1231 0242-0792 125 µM 1.48499609476407 0.0714974970092355 no 345 0.0687724293028563 420 3707635 SGTC_2936 9038235 15.59 µM 1.48495597272715 0.0715029060421843 no 346 0.0687777436506241 417 4749415 SGTC_617 3770-0098 35 µM 1.48469221359754 0.0715384724192078 no 347 0.0688126876399724 411 5962639 SGTC_1625 st003711 30.1 µM 1.47913263904215 0.0722913111596563 no 348 0.0695524342088332 417 24207034 YER133W GLC7 SGTC_2179 6298986 200 µM 1.47913084114701 0.0722915555962501 no 349 0.0695526744199061 394 738374 SGTC_1959 st077091 55.8 µM 1.47851390180173 0.0723754702787521 no 350 0.0696351394557577 462 821356 YKL052C ASK1 SGTC_349 k015-0014 24 µM 1.47526420524856 0.0728187190364361 no 351 0.0700707629177993 416 2196908 SGTC_2773 thioridazine 9.09 µM 1.4726194192073 0.0731809914307067 no 352 0.0704268427754212 437 5452 An antipsychotic. SGTC_3299 9121982 43.1275 µM 1.46952373780253 0.0736067755316244 no 353 0.0708453940745736 445 17594604 YPL160W CDC60 SGTC_2401 5128683 200 µM 1.45791586552884 0.0752202167396153 no 354 0.0724318674726628 406 708373 SGTC_3179 9107801 49.47 µM 1.45788203972797 0.0752249574577278 no 355 0.0724365299673222 434 4818259 SGTC_1180 1193-0155 285 µM 1.45475706881434 0.075663908434932 no 356 0.0728682636208231 439 2921347 SGTC_2345 9052315 157.45 µM 1.45272605749737 0.0759502401956268 no 357 0.0731499145672457 442 6469265 SGTC_2159 5658611 73.75 µM 1.44882878464687 0.0765019868538046 no 358 0.073692701536761 414 793844 SGTC_3122 9126309 49.47 µM 1.44838936250039 0.0765643877303982 no 359 0.0737540940511313 406 17591206 SGTC_3158 9100007 49.47 µM 1.44292350036367 0.0773438157191829 no 360 0.0745210111486732 386 19297233 SGTC_610 4215-0184 155 µM 1.4405636513919 0.0776821853749663 no 361 0.0748539977819093 480 5605015 SGTC_729 4092-0585 94.1 µM 1.43919704152467 0.0778786514782909 no 362 0.0750473516931877 427 2169061 SGTC_1972 st070201 17.4 µM 1.43846671320984 0.0779837991746297 no 363 0.0751508377704336 450 2829099 SGTC_1394 3474-0001 65.7 µM 1.42941342360216 0.0792961884273247 no 364 0.0764427212278649 405 5017666 YIL048W NEO1 SGTC_1127 asiatic acid 681.4 nM 1.42790446497119 0.0795165473319997 no 365 0.0766596791482688 468 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1712 st032288 53.4 µM 1.42451835026195 0.0800127206419781 no 366 0.0771482384749947 651 2883011 SGTC_1547 harmine 94.2 µM 1.42152937987503 0.0804526417061475 no 367 0.0775814593244697 543 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_311 1315-0136 58 µM 1.41608523444149 0.0812586107215636 no 368 0.0783752753339242 461 6759207 SGTC_3343 9148379 18.9835 µM 1.41402879347538 0.0815646329077924 no 369 0.0786767242436925 450 1955036 SGTC_3068 9116768 49.47 µM 1.41148702227604 0.0819440777274733 no 370 0.0790505297858033 438 41904888 SGTC_2201 6605497 169.863 µM 1.40653348463267 0.0826873795863265 no 371 0.0797828843710382 429 670741 SGTC_1793 st048256 72.231 µM 1.40597477395911 0.0827715341899289 no 372 0.0798658078217786 436 672022 SGTC_1860 st056228 74.6 µM 1.40516605646465 0.0828934596711373 no 373 0.0799859525458469 455 688679 SGTC_230 MPP+ 141.667 µM 1.40466309353855 0.0829693564884394 no 374 0.0800607426409159 462 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_846 0335-0850 148 µM 1.40460354324202 0.0829783460537395 no 375 0.0800696012110097 430 6819598 SGTC_1317 1273-0028 910 nM 1.40454070413723 0.0829878328838148 no 376 0.0800789498204472 470 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3255 9139072 49.47 µM 1.4024477868584 0.0833042672259947 no 377 0.0803907859406687 467 17646060 SGTC_2204 7233102 200 µM 1.40130504421482 0.0834774242548738 no 378 0.0805614367224968 399 2172480 SGTC_1048 3161-0300 24.5 µM 1.39256913778916 0.084810103136101 no 379 0.0818750605277052 522 2165101 SGTC_1985 st071382 65.5 µM 1.39206336105561 0.0848877460640328 no 380 0.0819516059669443 469 6123237 SGTC_3026 9090633 49.47 µM 1.39035197506998 0.0851508600228214 no 381 0.0822110110928286 493 25236842 SGTC_1736 st036774 51 µM 1.38876578183322 0.0853952717146396 no 382 0.0824519917958623 505 1272247 SGTC_2730 imipramine 71.33 µM 1.38421088107346 0.0861000433140314 no 383 0.0831469462708881 592 3696 A tricyclic antidepressant. SGTC_731 3966-0296 387 µM 1.38149003788039 0.0865231054036063 no 384 0.0835641693999009 478 660956 SGTC_811 0416-0114 265 µM 1.37963343059665 0.0868126787680589 no 385 0.0838497694214765 473 6612453 SGTC_443 clozapine 122 µM 1.37702614944835 0.0872205557237611 no 386 0.0842520816473182 396 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_791 1348-1292 225 µM 1.37542256077268 0.0874721270510883 no 387 0.0845002392759824 590 5437054 SGTC_1103 duloxetine 36.1 µM 1.37223496193083 0.0879738057415008 no 388 0.0849951524335539 556 60835 A selective serotonin reuptake inhibitor. SGTC_1246 0422-0085 105 µM 1.37120404225329 0.0881365148297134 no 389 0.0851556792297742 556 264295 SGTC_2997 9067075 71.4286 µM 1.36800559978383 0.0886427496783237 no 390 0.085655161648257 544 27209819 SGTC_2089 5281248 129.67 µM 1.367475631249 0.0887268394131772 no 391 0.0857381352012066 508 2737878 SGTC_1964 st076914 61 µM 1.36732826697323 0.088750232151841 no 392 0.0857612177071077 464 24208661 SGTC_2430 5571206 200 µM 1.3672327954956 0.0887653898321355 no 393 0.0857761744313504 565 1731771 SGTC_2327 6189656 200 µM 1.36567309277317 0.089013291574835 no 394 0.0860207966974992 470 5349088 SGTC_2543 pimpinellin 60.67 µM 1.36566081052517 0.0890152457787034 no 395 0.0860227251026653 474 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2311 7694451 200 µM 1.36545423586611 0.089048118244277 no 396 0.0860551637225892 497 2163142 SGTC_1399 3562-5772 25 µM 1.36434618532082 0.0892245978435274 no 397 0.086229318199425 408 23847490 SGTC_2246 7293507 91.5585 µM 1.36412422084953 0.0892599814689591 no 398 0.0862642364612465 520 887656 SGTC_1453 4237-0541 195 µM 1.36009934449662 0.0899034041191338 no 399 0.0868992442467805 497 739892 SGTC_3081 9117243 49.47 µM 1.35947639127842 0.0900032976046759 no 400 0.0869978393288226 471 45595589 SGTC_1176 0848-0131 83.3 µM 1.35889995794771 0.0900958048526006 no 401 0.0870891460973276 562 6769040 SGTC_3342 9147791 14.508 µM 1.35883613989047 0.0901060508519684 no 402 0.087099259246334 494 1838168 SGTC_118 0083-0097 135.343 µM 1.35666349359357 0.0904553861655773 no 403 0.0874440785579817 755 5207356 SGTC_2298 7976326 193.81 µM 1.3516616605677 0.091263441202106 no 404 0.0882417876006262 432 2235818 SGTC_3283 9109332 35.8195 µM 1.35061454845034 0.091433279457025 no 405 0.0884094689930778 407 17027281 SGTC_3056 9094900 49.47 µM 1.34879286917737 0.0917293081675674 no 406 0.088701752884759 494 25236784 SGTC_1659 st012954 42.1 µM 1.34840027706413 0.0917931985397822 no 407 0.0887648374610356 491 24207262 SGTC_2794 7785382 27.27 µM 1.33723066630482 0.0936247750667781 no 408 0.090573677381396 617 2205081 SGTC_1790 st045711 43.5 µM 1.33712049875869 0.0936429736056451 no 409 0.0905916535075292 505 585119 SGTC_3149 9097855 49.47 µM 1.33601085549927 0.0938264208579721 no 410 0.0907728625792855 502 25236625 YMR079W SEC14 SGTC_2807 7945238 51.95 µM 1.33535998841925 0.0939341461636201 no 411 0.0908792767924787 536 17148797 SGTC_1153 4055-0057 267 µM 1.33105657666588 0.0946487035714418 no 412 0.0915851977849005 527 882706 SGTC_1268 0828-0275 2.46 µM 1.3274055495878 0.0952580710306485 no 413 0.0921872824537656 532 745337 SGTC_756 0508-1999 28.3 µM 1.32628983542878 0.0954448621160884 no 414 0.092371856199023 511 6753853 SGTC_2764 methyldopa 94.69 µM 1.32387558078916 0.0958499753936495 no 415 0.0927721846907103 547 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_211 3455-0679 143.504 µM 1.32201977652657 0.0961622391021246 no 416 0.0930807827774296 549 748649 SGTC_1339 1486-1321 22.7 µM 1.32186822820882 0.0961877721101229 no 417 0.0931060169214263 541 3469382 SGTC_2858 9025781 8.96 µM 1.32153144750783 0.0962445310930919 no 418 0.0931621120076589 663 4894980 YPL153C RAD53 SGTC_294 k038-0071 157 µM 1.32076191879693 0.0963743151941908 no 419 0.0932903804751456 541 24152826 SGTC_1485 3909-9022 254 µM 1.31953133761833 0.0965821248462506 no 420 0.0934957703072518 539 714516 SGTC_382 3229-0966 23.2 µM 1.31767910291115 0.0968955341631355 no 421 0.0938055464287477 561 5722370 SGTC_2068 5226020 147 µM 1.31579336824686 0.0972153782961205 no 422 0.0941217028783528 582 1810509 SGTC_74 000s-0487 160.283 µM 1.31571954577195 0.0972279152484834 no 423 0.0941340956969967 528 677548 SGTC_1742 st038235 28.8875 µM 1.31331285009833 0.0976372840171171 no 424 0.0945387751262868 568 564103 YBR002C RER2 SGTC_1830 st055982 50.3 µM 1.31120013047892 0.0979976891873921 no 425 0.0948950791510718 546 455313 An antimicrobial agent. SGTC_1825 st052143 62.6 µM 1.3048885257178 0.0990801797518322 no 426 0.0959654044599938 485 674173 SGTC_1481 3346-2004 36 µM 1.30261086977516 0.099472955596771 no 427 0.0963538224597266 545 2770522 SGTC_1623 st003709 20.3 µM 1.30235743499035 0.0995167300290505 no 428 0.0963971130594877 623 16192618 SGTC_1015 4130-4525 82 µM 1.29963671726778 0.0999875521304619 no 429 0.0968627545374582 552 1363237 SGTC_1607 st000305 50.6 µM 1.2990373450629 0.100091492199019 no 430 0.0969655566496124 559 5457690 SGTC_2531 methyl deoxycholate 70.07 µM 1.29700292099006 0.100444879932585 no 431 0.0973150908803701 523 16667744 Haematoxylin. SGTC_453 enantio-paf c16 10 µM 1.29265889567432 0.101202500407912 no 432 0.0980645300459193 726 13871343 A lipid and platelet activating factor SGTC_3010 9080089 71.4286 µM 1.28790918549445 0.102035630630799 no 433 0.0988887888139145 551 17027233 SGTC_2252 omeprazole 400 µM 1.28642014756533 0.10229784231034 no 434 0.0991482353340708 448 4594 A proton pump inhibitor. SGTC_60 0986-0278 202 µM 1.2836501684063 0.102786924101057 no 435 0.099632193791718 426 3110598 SGTC_1730 st033808 45.1 µM 1.2820790247325 0.103065087419252 no 436 0.099907463076091 626 1045166 SGTC_748 act1.228 77.9 µM 1.27886527433609 0.103635768422402 no 437 0.100472251483648 615 4421505 YNR035C ARC35 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.27751417586338 0.103876372787501 no 438 0.100710389463364 642 65057 A dermal irritant. YDR527W RBA50 SGTC_1501 4491-0275 38.4 µM 1.2768656358189 0.10399200896256 no 439 0.100824844059186 550 5104718 SGTC_1449 4112-4002 201 µM 1.27518112591789 0.104292796975596 no 440 0.101122570073149 535 2059539 SGTC_153 4077-0274 519.67 µM 1.27332898514196 0.104624244580075 no 441 0.101450662713275 521 3121976 SGTC_303 1348-1668 34.2 µM 1.2726143661149 0.104752332133499 no 442 0.101577459107886 534 5380509 SGTC_2123 5259487 200 µM 1.27209830212598 0.104844901482586 no 443 0.10166909718923 602 2173474 SGTC_205 1486-1330 71.903 µM 1.2678023101741 0.105617797681985 no 444 0.102434278498059 512 4118834 SGTC_2598 perillyl alcohol 100 µM 1.26758359154179 0.105657257493198 no 445 0.102473347324802 578 10819 An apoptosis inducer. SGTC_2570 licareol 100 µM 1.26716953050065 0.105731988915948 no 446 0.10254733904537 572 443158 SGTC_3228 9131799 49.47 µM 1.2649332942442 0.106136254468676 no 447 0.102947620522331 554 17015818 SGTC_705 1124-0212 310 µM 1.26455262332682 0.106205183019922 no 448 0.10301587270148 600 9554485 SGTC_2034 5197015 53.07 µM 1.26381721027665 0.10633843672731 no 449 0.10314782124737 588 780676 SGTC_2745 rifampicin 24.3 µM 1.25995014465743 0.107041119416988 no 450 0.103843673869878 425 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_800 3448-7362 155 µM 1.25879217511805 0.107252183653058 no 451 0.104052703705017 845 15991913 SGTC_2107 5363541 170.161 µM 1.25737889808946 0.107510189419876 no 452 0.104308233323641 573 244052 SGTC_1984 st072354 53.1 µM 1.25696219669571 0.107586347125617 no 453 0.104383662372299 569 5762938 SGTC_1748 st037455 53.6035 µM 1.25683013049414 0.107610492085977 no 454 0.104407576533639 581 580690 SGTC_713 1488-1073 324 µM 1.24863977192034 0.109115529465121 no 455 0.105898429337741 578 3312542 SGTC_718 1130-0073 349 µM 1.24527232339743 0.109738690538692 no 456 0.106515832762 616 6740020 SGTC_1361 1608-0041 5.61 µM 1.24453048031834 0.109876314563007 no 457 0.106652194264567 594 X1361 SGTC_3144 9087057 49.47 µM 1.24205980803454 0.110335557797 no 458 0.10710724811753 576 17249618 SGTC_593 1203-0218 61.7 µM 1.23755266729287 0.111176877973057 no 459 0.10794098712901 622 3666956 SGTC_2052 5265182 7.135 µM 1.23570026788373 0.111523982478281 no 460 0.108284998973324 635 1239884 SGTC_135 0933-0004 26.348 µM 1.23566456358083 0.111530680396181 no 461 0.108291637414421 569 21230617 YGL099W LSG1 SGTC_1661 st013063 9.66 µM 1.23128320455047 0.11235478378952 no 462 0.109108480658462 661 721395 SGTC_1234 0326-0494 15.5 µM 1.22591873783998 0.113369716200052 no 463 0.110114628352453 586 1547813 SGTC_1358 1509-0022 2.48 µM 1.22089738587364 0.11432564246374 no 464 0.111062437194176 606 3258434 SGTC_263 alizarin 107.927 µM 1.22029776216507 0.114440176657491 no 465 0.111176008917553 690 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_594 1487-1584 10.8 µM 1.21797286758896 0.114885027316603 no 466 0.111617141773934 609 5013332 SGTC_2753 fluvastatin 17.09 µM 1.21535975464046 0.115386492962896 no 467 0.112114455286558 623 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1377 2944-0135 198 µM 1.21350255730804 0.115743840129595 no 468 0.112468868619267 628 1894137 SGTC_2301 7769476 200 µM 1.21100352451398 0.116225923571632 no 469 0.112947026955508 553 977820 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.20948177649242 0.116520178029933 no 470 0.113238904061079 537 6857784 SGTC_2411 st077133 39.94 µM 1.20846287208859 0.116717494681601 no 471 0.113434634355245 682 1403142 YNL221C POP1 SGTC_3052 9092717 49.47 µM 1.2081050027809 0.116786854299649 no 472 0.113503437832829 578 25237534 SGTC_2431 5490079 200 µM 1.20638310015256 0.117120989420719 no 473 0.113834904602114 622 5722345 SGTC_1941 st076221 61.8 µM 1.2048923597216 0.117410814077971 no 474 0.114122429238951 667 2828568 SGTC_39 0986-0283 58.349 µM 1.20369177363316 0.11764459685013 no 475 0.114354366504151 689 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_742 0kpi-0133 140 µM 1.20122479280338 0.118126010581718 no 476 0.114832007293979 642 2728852 SGTC_2030 5175110 200 µM 1.19948841422191 0.118465686831824 no 477 0.115169043541071 620 2831986 SGTC_406 estrone 100 µM 1.19831501857453 0.118695620998331 no 478 0.115397200980891 637 5870 A steroid. SGTC_3183 9108214 49.47 µM 1.19385975686816 0.119571527952361 no 479 0.116266415877043 491 4974831 SGTC_3251 9135047 49.47 µM 1.19147424243126 0.120042391179657 no 480 0.116733731255254 562 17682963 SGTC_2121 5257820 149.641 µM 1.19092321581867 0.120151340757396 no 481 0.116841864841521 678 791256 SGTC_1420 4'-methoxyflavone 42 µM 1.19091518307594 0.120152929515085 no 482 0.116843441713661 625 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1324 1418-0026 34.4 µM 1.19071025648113 0.120193465970412 no 483 0.116883675047084 650 1372513 SGTC_2933 9026794 32.47 µM 1.18981655729755 0.120370360924846 no 484 0.117059250209418 645 17586027 SGTC_2310 7668677 200 µM 1.18886544429237 0.120558821468967 no 485 0.117246310010491 620 2197143 SGTC_2115 tiliquinol 12.7705 µM 1.18816337467709 0.120698067941489 no 486 0.117384525058433 605 71208 A bioactive hydroxyquinoline. SGTC_529 4076-0302 30.3 µM 1.18750523438088 0.120828704378063 no 487 0.117514196571673 624 5816522 SGTC_2663 amphotericin b 100 µM 1.18701933577407 0.120925215827816 no 488 0.117609996848847 579 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1337 1486-1011 40.3 µM 1.1847021852273 0.121386205201754 no 489 0.11806760908668 615 X1337 SGTC_442 cape 100 µM 1.18449144374707 0.12142819273238 no 490 0.118109290646948 580 5281787 SGTC_272 doxorubicin 8.13 µM 1.18244230027763 0.121836990601034 no 491 0.118515123662537 697 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1273 0849-0096 14.1 µM 1.18199351395398 0.121926651016946 no 492 0.118604137226372 643 5286025 SGTC_273 hydroxyurea 18.1 mM 1.17793454487312 0.122739674345806 no 493 0.119411350957845 710 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1165 k072-0275 30.3 µM 1.17750945412586 0.122825040710375 no 494 0.119496113149032 616 6153523 YGL055W OLE1 SGTC_2474 5321570 43.32 µM 1.17654543576407 0.123018788317735 no 495 0.119688493618028 611 2841384 SGTC_421 streptovitacin 30 mM 1.17643841792123 0.123040309879729 no 496 0.119709863668176 672 91467 include heat shock SGTC_2174 5790901 200 µM 1.17631868699039 0.123064391204366 no 497 0.119733775543235 622 786020 SGTC_1169 aniline yellow 25.8 µM 1.17421530321311 0.123487980920286 no 498 0.120154398957998 603 6051 A DNA damaging agent. SGTC_2585 alliin 100 µM 1.16884522572565 0.124574062019096 no 499 0.12123299762945 663 87310 A garlic compound which reacts with lipids. SGTC_1038 k292-0204 154 µM 1.16443497769751 0.125471000962866 no 500 0.122123889804958 604 4454212 SGTC_2532 xanthone 78.9 µM 1.16372068656139 0.125616693744287 no 501 0.12226861163807 586 7020 An insecticide. SGTC_2463 5473429 200 µM 1.16347382549017 0.125667073024707 no 502 0.122318655902093 633 5399405 SGTC_2445 5742597 35.57 µM 1.16077910001642 0.126217928103226 no 503 0.122865872242802 621 1774255 SGTC_2866 9034245 58.44 µM 1.16071129844184 0.126231809754718 no 504 0.122879662773519 618 6462273 SGTC_2757 clomiphene 4.22 µM 1.15792049978869 0.1268041196026 no 505 0.123448240480121 751 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_605 1315-0399 119 µM 1.15726389530955 0.126939031774153 no 506 0.123582279835241 693 24020461 SGTC_3293 9120939 62.045 µM 1.15664479206298 0.127066330074014 no 507 0.123708757009346 639 934087 SGTC_402 epigallocatechin gallate 10 µM 1.15592634993056 0.127214165492867 no 508 0.123855641790248 680 65064 An antioxidant. SGTC_1331 1472-0049 76.2 µM 1.15308842081271 0.127799302137023 no 509 0.124437046918366 625 24051409 SGTC_1078 idebenone 36.1 µM 1.15248650105509 0.127923648639536 no 510 0.124560606829664 708 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_588 3970-1144 52.9 µM 1.15066712437223 0.128300012242226 no 511 0.124934603230318 678 1888707 SGTC_2741 miltefosine 3.04 µM 1.15049782388582 0.128335073484689 no 512 0.124969444988476 549 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3047 9092122 49.47 µM 1.14175331387728 0.130155066681387 no 513 0.126778286573293 636 17173831 SGTC_1200 1643-0193 18.4 µM 1.14164537787694 0.130177642411955 no 514 0.126800726935704 702 5403974 SGTC_194 1486-1323 56.904 µM 1.13979264843226 0.130565578973835 no 515 0.12718634861472 658 5178754 SGTC_519 k048-0011 62.8 µM 1.13914411193552 0.130701562468329 no 516 0.127321525699529 649 6836379 SGTC_1905 st060207 84.5 µM 1.13881160180028 0.130771320307919 no 517 0.127390870871811 673 1948547 SGTC_2819 7996655 46.38 µM 1.137995888216 0.130942559172347 no 518 0.127561099639613 578 6456960 SGTC_1458 k015-0034 6.33 µM 1.13755549989549 0.131035072171552 no 519 0.127653068641887 633 3598957 SGTC_2994 9053520 71.4286 µM 1.13478925947336 0.131617212862368 no 520 0.12823181374853 685 4647384 SGTC_1933 st074711 15.9 µM 1.13473134085819 0.131629420576021 no 521 0.128243950763068 706 17250958 SGTC_2255 7941087 197.44 µM 1.13458621037763 0.131660013678638 no 522 0.128274366781819 755 935561 SGTC_2243 6634756 200 µM 1.13432847789824 0.131714355063741 no 523 0.12832839394166 627 885676 SGTC_473 2-arachidonoylglycerol 10 µM 1.12885937666433 0.132871132651891 no 524 0.129478579981362 658 5282280 An endocannabinoid. SGTC_246 cycloheximide 667 µM 1.12809387268705 0.133033601899252 no 525 0.129640138292633 591 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2276 7947513 42.08 µM 1.12681085496664 0.133306213938308 no 526 0.129911230021162 624 2105100 SGTC_1670 st016595 4.04 µM 1.12625383353304 0.13342468787568 no 527 0.130029046438602 686 597879 SGTC_2090 5301565 104.445 µM 1.12559232437899 0.133565479556748 no 528 0.130169059246526 753 2056344 SGTC_161 4065-0411 162.148 µM 1.12394710766584 0.133916080617192 no 529 0.130517732565375 730 1906281 YLR208W SEC13 SGTC_1440 4100-1550 40 µM 1.12280157640571 0.134160570254334 no 530 0.130760887861028 669 742806 SGTC_1290 0986-0249 10.2 µM 1.12012433389448 0.134733166688967 no 531 0.13133039117044 627 53329 SGTC_950 1165-0508 94.1 µM 1.11725836441616 0.135347983177558 no 532 0.131941936049553 652 6148369 SGTC_2895 9054447 58.44 µM 1.11635400478643 0.135542387670597 no 533 0.132135316704137 669 2697450 SGTC_1874 staurosporine 7.6 µM 1.11557833196524 0.13570928152235 no 534 0.132301335670589 718 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_449 xestospongin c 11.1929 µM 1.11542330793086 0.135742653380793 no 535 0.132334533038494 721 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1645 Cervolide 78 µM 1.11435344231103 0.135973115454156 no 536 0.132563794192554 661 23173 A fragrance. SGTC_1812 st052057 4.327 µM 1.11369065448629 0.13611602232181 no 537 0.132705959970217 714 3645418 SGTC_1012 4112-3522 18 µM 1.11356007506736 0.136144189295047 no 538 0.132733981197951 697 3112398 SGTC_724 3910-0327 137 µM 1.11316516627873 0.13622939839692 no 539 0.132818750046998 709 2885483 SGTC_392 N-ethylmaleimide 8.33 µM 1.1118885846736 0.136505094847083 no 540 0.133093028713903 663 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1971 st069429 63.5 µM 1.1108131197189 0.136737653189867 no 541 0.133324399019801 670 1246522 YGL099W LSG1 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.11055960882574 0.136792511765179 no 542 0.133378978400072 552 88881 An O-methylated flavonoid and antioxidant. SGTC_2622 2-methoxyxanthone 59.94 µM 1.10420221380696 0.138173142958789 no 543 0.134752714779367 759 71034 A hepatoprotective. SGTC_2147 5545932 89.7195 µM 1.09975473417245 0.139144628775862 no 544 0.135719499848712 679 797404 SGTC_1349 flufenamic acid 69 µM 1.0987204778674 0.139371211321778 no 545 0.135945003808858 682 3371 A non-steroidal anti-inflammatory. SGTC_2175 5807670 165.306 µM 1.09710147650749 0.139726402260803 no 546 0.136298517433231 689 241186 SGTC_2059 5238311 157 µM 1.09490173424149 0.140209986683997 no 547 0.136779844604456 670 703021 SGTC_2695 st077686 51.995 µM 1.09322356831548 0.140579672997445 no 548 0.137147825753998 676 2876092 SGTC_1116 jasmonic acid  1.58368 µM 1.09267810300274 0.140699976921705 no 549 0.13726757859014 735 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1843 st055809 45.5 µM 1.09116333438477 0.141034429770024 no 550 0.137600509182228 689 16413835 SGTC_1865 st057639 52.2 µM 1.0892044110521 0.141467748526752 no 551 0.138031877089866 708 688818 SGTC_2601 securinine 100 µM 1.08909417093116 0.141492160703562 no 552 0.138056180077294 690 442872 A GABA receptor antagonist. SGTC_2536 dehydroabietamide 32.04 µM 1.08801275201997 0.141731787383723 no 553 0.138294739020484 761 3983547 SGTC_3111 9122088 49.47 µM 1.08688986555748 0.141980893394485 no 554 0.138542742840553 589 16876704 SGTC_2888 9058547 12.99 µM 1.08670523531416 0.142021880927535 no 555 0.138583549779923 618 16476514 SGTC_3247 9135149 49.47 µM 1.08532238037903 0.142329126526888 no 556 0.138889448455144 663 8934436 YOR116C RPO31 SGTC_2051 5263410 176 µM 1.08483074454298 0.142438467482997 no 557 0.13899831297447 748 227584 SGTC_1953 st076800 12.1 µM 1.084782935836 0.142449103281338 no 558 0.139008902510049 718 297591 SGTC_1031 k035-0009 16 µM 1.08171505294159 0.143132725403187 no 559 0.139689581173283 784 5180959 SGTC_3007 9078383 71.4286 µM 1.07972383017895 0.143577617481718 no 560 0.140132589435941 733 6496995 SGTC_47 0149-0135 24.25 µM 1.07961454004337 0.143602062793155 no 561 0.140156931961222 678 5239155 SGTC_357 1325-0123 420 µM 1.07785077264969 0.143996959372779 no 562 0.140550178515982 699 1098503 SGTC_466 geldanamycin 89.2 µM 1.07484135002928 0.144672439929629 no 563 0.141222881986169 601 5288382 HSP90 inhibitor. SGTC_2571 chrysanthemic acid 100 µM 1.06905972183052 0.145976136881811 no 564 0.142521379759076 688 2743 An insecticide. SGTC_3271 9137798 49.47 µM 1.06775809635582 0.146270725100615 no 565 0.142814822287587 656 6498326 SGTC_1500 4488-1866 171 µM 1.06378851764288 0.147171597288494 no 566 0.14371225705525 791 2900003 SGTC_2134 5324836 1.464 µM 1.06302426318479 0.14734546636735 no 567 0.143885474149601 659 699272 SGTC_1770 st043884 66.3 µM 1.06258715108533 0.147444971907906 no 568 0.143984608218468 740 670149 SGTC_2377 9073351 62.6 µM 1.06142711019412 0.147709265439106 no 569 0.144247920954391 698 7337946 YHR072W ERG7 SGTC_1188 1403-0014 4.57 µM 1.06002113261144 0.148030016069709 no 570 0.144567492690392 795 9614867 SGTC_3292 9120825 59.784 µM 1.05988669538604 0.148060710108471 no 571 0.144598074570537 769 24824900 SGTC_1395 3486-0190 4.35 µM 1.05971947457487 0.148098895076195 no 572 0.144636120166686 792 6748079 SGTC_1502 4534-4282 27.7 µM 1.05799544804126 0.148492961729384 no 573 0.14502875883188 707 3278949 SGTC_3061 glucosamine 200 µM 1.05464635561873 0.149260477618241 no 574 0.14579354728718 720 91431 and experimental redox chemotherapeutic SGTC_2588 indole-3-carbinol 100 µM 1.05313746748185 0.14960713551397 no 575 0.146138996529657 795 3712 Induces cell cycle arrest. SGTC_3217 9129673 49.47 µM 1.05064231098586 0.150181560439398 no 576 0.146711450341942 709 17248312 SGTC_2874 9043904 71.43 µM 1.05040781429241 0.150235620799832 no 577 0.146765327225031 648 4463428 SGTC_905 2-aminofluorene 215 µM 1.05017271250474 0.15028983367564 no 578 0.146819356455642 814 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2770 toltrazuril 17.5 µM 1.04797236751915 0.150797850213768 no 579 0.147325669087826 788 68591 Kills coccidiodes. SGTC_1160 4092-0570 10.5 µM 1.04704249331505 0.151012883208705 no 580 0.147539990084259 759 4994975 SGTC_1257 0669-0121 16 µM 1.04645440614598 0.151148983389015 no 581 0.14767564245194 827 4307855 SGTC_491 tetrandrine 80.3 µM 1.04621376329495 0.151204698544576 no 582 0.147731174919289 720 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2943 9068529 45.32 µM 1.04461959334173 0.151574135865388 no 583 0.148099410145357 817 3270634 SGTC_1304 1165-0502 251 µM 1.04173083111312 0.152245113168709 no 584 0.148768245304266 789 767425 SGTC_3312 9133330 71.43 µM 1.03429755272401 0.153980704980348 no 585 0.150498540300473 816 17617324 SGTC_2017 5132927 60.65 µM 1.03324200237156 0.154228222197658 no 586 0.150745330619304 753 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2541 muurolladie-3-one 83.07 µM 1.03215368388127 0.154483698623059 no 587 0.151000064187184 735 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_483 fpl-64176 144 µM 1.0316452858649 0.154603137904839 no 588 0.151119158751024 710 3423 SGTC_2022 5136654 200 µM 1.02848635584591 0.15534664100951 no 589 0.151860552858005 747 1713771 SGTC_10 0279-0212 42.575 µM 1.02817797275537 0.155419349957536 no 590 0.151933058962446 869 39851 YBR002C RER2 SGTC_1047 2043-3044 82 µM 1.0272853953209 0.15562992371873 no 591 0.152143048673109 793 669592 SGTC_936 3005-4620 401 µM 1.02721178476491 0.155647298060214 no 592 0.152160375050988 836 777207 SGTC_616 4092-0450 108 µM 1.02277394027056 0.156697128463907 no 593 0.153207371047946 817 787165 SGTC_2743 auranofin 4.32 µM 1.01901385966917 0.157590263889495 no 594 0.154098193364087 750 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1293 1000-1278 195 µM 1.01840078579508 0.157736204415937 no 595 0.154243764460694 810 678847 SGTC_2139 5578692 56.4705 µM 1.01750695067284 0.157949138393168 no 596 0.154456163711104 730 650991 YMR113W FOL3 SGTC_485 niflumic acid 177 µM 1.0170438869679 0.15805952597988 no 597 0.154566276089329 749 4488 A COX2 inhibitor. SGTC_2337 9009472 200 µM 1.01307766845705 0.159007088268746 no 598 0.155511532003097 806 5742383 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.01151167640605 0.15938223948924 no 599 0.155885797719928 745 688803 SGTC_2097 5376186 200 µM 1.00815262150044 0.160188892452907 no 600 0.156690599432148 796 742755 SGTC_2350 9023895 38.85 µM 1.00286358898886 0.161464415573901 no 601 0.15796334132488 780 2997209 SGTC_2172 5754775 163.918 µM 1.00209644575278 0.161649971196176 no 602 0.158148507174277 718 2263357 SGTC_667 1498-1044 59 µM 1.00146667623298 0.161802402887228 no 603 0.158300621476986 833 6739982 SGTC_3130 9127414 49.47 µM 1.00093736679896 0.161930591276094 no 604 0.158428544912533 807 1494646 SGTC_578 3460-0051 92 µM 0.99966206199438 0.162239716808095 no 605 0.158737038852301 918 2876744 SGTC_855 0428-0020 25 µM 0.998854214740137 0.162435732331562 no 606 0.158932659253365 722 6812414 SGTC_88 0180-0332 8.668 µM 0.995901804082726 0.163153413654229 no 607 0.159648929335628 803 3101745 SGTC_3148 9097893 49.47 µM 0.991176344435558 0.164306375219196 no 608 0.160799739683799 752 17174100 SGTC_2581 avocatin a 64 µM 0.9873953827134 0.165232684560115 no 609 0.161724423514347 815 6710728 A skin care supplement. SGTC_2340 7987427 183.45 µM 0.98131765948205 0.166728753111941 no 610 0.16321805843927 783 2239331 SGTC_2026 5148700 152 µM 0.980624721825594 0.166899877294998 no 611 0.163388919251402 822 79838 SGTC_2746 daunorubicin 9.88 µM 0.980133743557267 0.167021195215067 no 612 0.163510052311695 701 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_751 0833-0568 350 µM 0.97992633713793 0.167072461235532 no 613 0.163561240677381 813 6954252 SGTC_210 3551-0445 56.827 µM 0.978926197434671 0.167319814813883 no 614 0.163808223436007 820 2865180 YOR207C RET1 SGTC_1569 carminic acid 40.6 µM 0.978510442506299 0.167422708330995 no 615 0.163910964580404 851 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3060 1327-0027 12.5 µM 0.976087306656915 0.1680232115564 no 616 0.164510600515692 791 16000455 YPR107C YTH1 SGTC_2238 6671620 73.2395 µM 0.974098087544118 0.168517215972483 no 617 0.165003919508874 793 729941 SGTC_477 mead ethanolamide 10 µM 0.971772674361735 0.169095893739643 no 618 0.165581826443005 698 16061185 SGTC_2983 9022671 12.99 µM 0.971277126581794 0.169219375277634 no 619 0.165705147962802 803 6405161 SGTC_1782 st039423 80.636 µM 0.969912393123828 0.169559741326353 no 620 0.166045081047332 767 2068169 SGTC_1832 st054113 55 µM 0.96759438610453 0.170138860697267 no 621 0.166623491035981 805 1251267 SGTC_923 1900-2434 73.3 µM 0.967581088245954 0.170142186620608 no 622 0.166626812984338 813 5910570 SGTC_435 c-PAF 6.7 µM 0.967465609492446 0.170171070728168 no 623 0.1666556626185 852 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1474 0330-0125 5.35 µM 0.966014547385078 0.170534285212198 no 624 0.167018450866982 846 X1474 SGTC_259 usnic acid 108.925 µM 0.965147831906428 0.170751468862342 no 625 0.167235386069503 858 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2665 lovastatin 100 µM 0.964495812996121 0.170914969957671 no 626 0.167398703291392 816 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_852 0418-0143 439 µM 0.961271720877407 0.171724919035434 no 627 0.168207781460657 917 5369229 SGTC_1583 clindamycin 39.6 µM 0.960304670233692 0.171968336494962 no 628 0.168450950138859 748 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_910 3454-3003 490 µM 0.954890644752465 0.173335173371321 no 629 0.169816500614669 867 820824 SGTC_1836 st055642 81 µM 0.952822068874296 0.173859231792894 no 630 0.170340115333219 851 8571 SGTC_2544 sphondin 68.51 µM 0.951409114840843 0.174217771850414 no 631 0.170698367551928 821 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1721 st082152 9.2685 µM 0.951384864122025 0.174223929620065 no 632 0.170704520489427 805 5296051 SGTC_2654 protoveratrine a 100 µM 0.950105185274611 0.174549063310958 no 633 0.17102940437204 847 5702278 A heart drug and vasodilator. SGTC_2239 6685329 187.64 µM 0.942898048128736 0.176387402232416 no 634 0.172866526693257 842 805680 SGTC_2847 9005661 71.43 µM 0.942081453993771 0.17659646236156 no 635 0.17307546942317 772 2991449 SGTC_2693 st077581 40.7 µM 0.940309996521673 0.177050519979493 no 636 0.173529286713371 937 25238761 SGTC_631 k072-0230 41.5 µM 0.939925329761417 0.177149214637825 no 637 0.173627931783464 902 5773147 SGTC_133 0724-0033 378.92 µM 0.939132594763301 0.17735271769468 no 638 0.173831335573661 826 280309 SGTC_784 4579-0127 173 µM 0.937784512833381 0.177699122681985 no 639 0.174177580809349 931 1948547 SGTC_1226 3909-7979 35.4 µM 0.937718007399989 0.177716223051967 no 640 0.174194673593642 911 6615510 SGTC_121 0557-0495 61.343 µM 0.937611677505461 0.177743565539468 no 641 0.17422200401076 1084 3104427 SGTC_2975 9084847 53.72 µM 0.935000549949704 0.178415843635165 no 642 0.174894008004239 869 27211724 SGTC_2469 5655019 90.81 µM 0.93410950626058 0.178645623735827 no 643 0.175123704389413 932 2788239 SGTC_3058 9093861 49.47 µM 0.932976739553674 0.178938007661114 no 644 0.17541598911394 843 17217477 SGTC_2440 5628896 157.78 µM 0.931455646954121 0.179331097676332 no 645 0.175808958656806 870 5522048 SGTC_2027 5150920 200 µM 0.931395200381019 0.179346729857426 no 646 0.175824586352302 862 786715 SGTC_653 0203-0016 55.2 µM 0.92851965477787 0.180091368810395 no 647 0.176569038608882 886 295302 SGTC_1239 0337-0584 35.4 µM 0.927360000645873 0.180392216290648 no 648 0.176869825609363 940 914301 YML130C ERO1 SGTC_1447 4239-0816 81.9 µM 0.926353369869114 0.180653620624313 no 649 0.177131184356115 816 1341554 SGTC_957 1187-1561 14.1 µM 0.92584515938345 0.180785684146844 no 650 0.177263227305648 868 1538454 SGTC_968 1309-0633 340 µM 0.924280269060889 0.181192716346607 no 651 0.177670206456833 890 3761976 SGTC_176 1486-1328 72.834 µM 0.924220538619302 0.181208263759861 no 652 0.177685752153553 907 22310231 SGTC_3096 9117468 49.47 µM 0.924189584857529 0.181216321134728 no 653 0.177693808647793 768 41316311 SGTC_3118 9124250 49.47 µM 0.922569190207734 0.181638428952209 no 654 0.178115878874232 802 1504786 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.921673088934047 0.181872124560593 no 655 0.178349560870088 863 688662 SGTC_2959 9079155 11 µM 0.921322242856912 0.181963673445517 no 656 0.178441105818625 822 16189457 SGTC_2843 9000894 45.46 µM 0.920972698526362 0.182054911307451 no 657 0.178532340538789 747 2242070 SGTC_844 0330-0132 15.3 µM 0.9205048283838 0.182177079260187 no 658 0.17865450550512 942 2828079 SGTC_202 3594-0513 34.79 µM 0.919358537955694 0.182476609484733 no 659 0.178954034313257 855 708429 SGTC_15 0266-0086 27.098 µM 0.917366093662394 0.182997974632627 no 660 0.179475416961313 984 1712902 YIL048W NEO1 SGTC_1462 k081-0014 26.5 µM 0.917248434048634 0.183028791793736 no 661 0.179506235949059 721 3270634 SGTC_1318 1280-3875 124 µM 0.916010566522989 0.183353207683333 no 662 0.179830676422016 892 373245 SGTC_1867 st057372 64 µM 0.914086653379472 0.183858131078933 no 663 0.180335657494793 895 688837 SGTC_2351 9026858 72.31 µM 0.913957940586019 0.183891942121576 no 664 0.180369473242479 825 1409300 SGTC_1685 st024049 53.0905 µM 0.913349939956544 0.184051707688189 no 665 0.180529262470232 878 1941139 SGTC_3224 9130643 49.47 µM 0.912777395604588 0.184202235314202 no 666 0.180679814545123 857 17644395 SGTC_2918 7977171 22.06 µM 0.911140637393664 0.184632977830723 no 667 0.181110638559768 893 2236483 SGTC_789 1309-1135 70.6 µM 0.91069758091914 0.184749683781957 no 668 0.181227369531193 892 3092424 SGTC_2643 anethole 100 µM 0.908943012562174 0.185212306644407 no 669 0.181690103873049 947 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.906843764982852 0.185766754639005 no 670 0.182244711283999 942 3256 An antibiotic and ribosome inhibitor. SGTC_639 0833-0042 114 µM 0.904543550341069 0.186375462316568 no 671 0.18285362626061 933 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_292 k038-0015 474 µM 0.90447090915047 0.186394705519181 no 672 0.182872876566038 883 46368540 SGTC_1511 0906-3109 28.5 µM 0.903613830872624 0.186621844980549 no 673 0.183100102405776 994 2882180 SGTC_1578 josamycin 24.2 µM 0.903025142724505 0.186777955999939 no 674 0.183256275504619 830 5282165 A P450 substrate. SGTC_732 3970-1727 52.7 µM 0.902672292000138 0.186871565302613 no 675 0.183349923090735 915 1275699 SGTC_2151 5563267 85.4165 µM 0.901410367845915 0.187206584170901 no 676 0.183685085465644 930 5310824 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.901005259221385 0.187314212155967 no 677 0.183792761705297 894 2724278 An inhibitor of dopamine biosynthesis. SGTC_1901 st060216 58.6 µM 0.900579582910258 0.18742734570808 no 678 0.183905947106958 929 688792 SGTC_2817 7995342 71.43 µM 0.899701435876577 0.187660867459081 no 679 0.184139579529469 830 18879975 SGTC_2135 5326629 150.42 µM 0.897700615860138 0.188193607619183 no 680 0.184672590523949 858 5020077 SGTC_45 0kpi-0036 14.9 µM 0.894054080255835 0.189166934940085 no 681 0.185646478314648 860 2795021 SGTC_973 1325-0077 65.9 µM 0.891338180819932 0.189893868662209 no 682 0.186373885692364 988 2835149 SGTC_506 n9-isopropylolomoucine 153 µM 0.8910577237789 0.189969033098689 no 683 0.186449101779508 936 6610355 SGTC_3043 9092303 49.47 µM 0.889176069369767 0.19047380240035 no 684 0.186954230892089 890 25236084 SGTC_2740 felodipine 17.08 µM 0.888484199964957 0.190659608960748 no 685 0.18714017556554 855 3333 L-type calcium channel blocker SGTC_304 1310-0298 97 µM 0.887395336425734 0.190952256411158 no 686 0.187433046714344 923 1550234 SGTC_2628 lathosterol 100 µM 0.887023406068559 0.19105228104452 no 687 0.187533149534189 938 6710616 SGTC_2168 5727979 200 µM 0.884001309911083 0.191866215501176 no 688 0.188347752860073 864 695210 SGTC_1759 st043059 70 µM 0.883037122428834 0.192126343996432 no 689 0.188608107347343 928 669426 SGTC_396 dithiazanine 1.25 µM 0.883011912104558 0.192133148392523 no 690 0.188614917734173 899 10578 An antihelmenthic. SGTC_2424 5537928 59.2 µM 0.882786652596067 0.192193953635771 no 691 0.188675776690989 948 5382802 SGTC_2054 5233173 129 µM 0.880878946006149 0.192709380744496 no 692 0.189191672049549 933 6889 SGTC_2466 5983409 37.09 µM 0.879053431930895 0.193203390973604 no 693 0.189686152739185 900 2879657 SGTC_1970 st070122 35.8 µM 0.877831852423736 0.19353439916239 no 694 0.190017487986028 924 102928 SGTC_1275 0867-0008 21.1 µM 0.873864458228342 0.194611817298423 no 695 0.191096036127946 944 3422836 SGTC_544 k015-0020 52.4 µM 0.8727669238071 0.194910516036634 no 696 0.191395065802531 915 3008304 SGTC_3352 9151559 45.5865 µM 0.871259696722361 0.195321168423387 no 697 0.191806185625211 907 17159339 SGTC_2611 pyromycin 23.93 µM 0.870946748406608 0.195406498783968 no 698 0.191891614922806 917 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2988 9073640 71.4286 µM 0.868779150491759 0.195998150374347 no 699 0.192483969572223 901 9102229 SGTC_2565 isoliquiritigenin 100 µM 0.867775478239877 0.196272473074833 no 700 0.19275862834852 774 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1109 tnp00067 928.257 nM 0.867182672732155 0.196434607375167 no 701 0.192920964282538 929 676295 SGTC_2739 tacrine 100.86 µM 0.866247626895661 0.196690510487554 no 702 0.19317719017129 929 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_222 nsc-310342 10.666 µM 0.866119201632695 0.19672567364647 no 703 0.193212398115222 911 432556 SGTC_2664 lyso-paf C-16 73.48 µM 0.86530171198281 0.196949593602242 no 704 0.193436605714311 998 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1495 4469-0029 237 µM 0.86492171245296 0.197053732415862 no 705 0.19354087974491 1013 793680 SGTC_2285 7945142 200 µM 0.863989981269781 0.197309214200827 no 706 0.19379669712863 904 2970608 SGTC_1492 4158-0558 28.5 µM 0.863810201600572 0.197358533046464 no 707 0.193846081392268 948 3967268 SGTC_568 1193-0097 7.48 µM 0.862493002303425 0.197720106897823 no 708 0.194208141094418 937 3646150 SGTC_3029 9088683 49.47 µM 0.862038755786324 0.197844891250625 no 709 0.194333095670685 971 25236615 SGTC_2315 7733312 200 µM 0.861436925078296 0.198010291159816 no 710 0.194498723221862 897 726316 SGTC_2235 salicylic acid 500 µM 0.859948582086511 0.198419687905678 no 711 0.194908693280327 960 338 A COX inhibitor and kinase inhibitor. SGTC_340 k038-0059 454 µM 0.858318572544074 0.198868638172778 no 712 0.195358288350682 972 23733424 SGTC_734 2023-0417 80 µM 0.857920520942444 0.198978365677486 no 713 0.195468176006815 944 3935732 SGTC_274 sirtinol 40.1 µM 0.856196209384968 0.199454113189607 no 714 0.195944629475459 951 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3090 9117696 49.47 µM 0.847404844546529 0.201890328142377 no 715 0.19838475256731 951 7923821 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.842647396978427 0.203216082128037 no 716 0.199712837393286 946 17037758 SGTC_1302 1159-0335 255 µM 0.84245913046846 0.203268652864758 no 717 0.199765503495689 951 649284 SGTC_3294 9122953 26.2835 µM 0.842217858209288 0.203336036565145 no 718 0.199833009760024 1039 16459826 SGTC_2322 7413319 38.22 µM 0.841522858348395 0.203530214020902 no 719 0.200027542456901 1006 1840400 SGTC_3194 9111903 49.47 µM 0.840207297368055 0.203898074019109 no 720 0.20039608378617 972 17087251 SGTC_2186 6124449 200 µM 0.838854484737394 0.204276763317989 no 721 0.200775485858645 977 3834182 YLR033W RSC58 SGTC_2921 7974240 10.71 µM 0.837187919101303 0.204743855953119 no 722 0.201243473527735 966 2979074 YDR527W RBA50 SGTC_2856 9022925 19.48 µM 0.835448388891455 0.205232075519351 no 723 0.201732647287334 969 4944862 SGTC_1338 1486-1223 76 µM 0.83453090885969 0.205489855428176 no 724 0.201990938690002 1015 3444526 SGTC_2200 6600604 21.907 µM 0.83289473864737 0.205950039078833 no 725 0.202452048608755 1009 2904777 SGTC_1071 trifluoperazine 6.31 µM 0.83268632804762 0.206008699791561 no 726 0.202510828605237 1016 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.832307203734591 0.206115436191726 no 727 0.202617782749719 1037 5393153 SGTC_2967 9089538 49.85 µM 0.83173600472396 0.206276310059681 no 728 0.20277898651161 1030 728216 SGTC_3320 9137005 35.139 µM 0.829564747104365 0.206888507056966 no 729 0.203392457644111 917 4908713 SGTC_1179 1021-1431 9.29 µM 0.826959347838649 0.207624530075384 no 730 0.204130051675136 1020 2840958 SGTC_3164 9100705 49.47 µM 0.824979081288866 0.208184987090136 no 731 0.204691733520926 983 17174235 SGTC_934 2950-0684 338 µM 0.823157657349439 0.208701275661544 no 732 0.205209172157918 1039 1121253 SGTC_3188 9110789 49.47 µM 0.822863472073088 0.208784734168077 no 733 0.205292818527913 1007 849217 SGTC_2188 6126565 140.678 µM 0.821207181460731 0.209254980294198 no 734 0.20576413331126 975 874518 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.821157409761552 0.209269120879405 no 735 0.20577830629811 979 803109 SGTC_3318 9139014 38.6185 µM 0.819809988573497 0.209652148976305 no 736 0.206162217970118 973 16643984 SGTC_1994 st072947 40.9 µM 0.817449119132766 0.210324260655105 no 737 0.206835907559021 993 5286565 YDL195W SEC31 SGTC_1412 3909-8563 178 µM 0.817039686567667 0.210440949870887 no 738 0.206952874281492 1093 23767530 SGTC_2768 sulfasalazine 50.2 µM 0.812203354527381 0.211822188711041 no 739 0.208337477506679 1044 5384001 An antioxidant and salicylic acid derivative. SGTC_2782 7736369 71.43 µM 0.810111585300305 0.212421229841483 no 740 0.20893802317609 1050 2950836 YOL077C BRX1 SGTC_1487 3970-0795 2.82 µM 0.809500025328862 0.212596555281521 no 741 0.209113794132465 1046 3765103 SGTC_2140 5586273 200 µM 0.809072319402408 0.212719222619232 no 742 0.209236774567932 1024 854421 SGTC_2409 alverine citrate 63.97 µM 0.808974494652453 0.212747284855508 no 743 0.209264908591362 1007 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_428 3448-4153 16.5 µM 0.808947287455773 0.212755089959627 no 744 0.209272733672671 955 3834874 SGTC_579 4491-1009 110 µM 0.808233034351447 0.212960052151487 no 745 0.209478222121578 1205 1271041 SGTC_1671 st016596 74.5 µM 0.807645056871625 0.213128864701174 no 746 0.209647470504712 1092 2829167 SGTC_54 0159-0055 9 µM 0.807350455575101 0.213213476188863 no 747 0.20973230125152 1031 3319099 SGTC_1431 4049-0260 9.09 µM 0.803480641590295 0.214326730381824 no 748 0.210848490675811 1043 3854841 SGTC_3044 9093193 49.47 µM 0.803461355314 0.21433228704184 no 749 0.210854062220923 1053 25236277 SGTC_658 3253-0951 102 µM 0.801290272719626 0.214958343330963 no 750 0.211481810424862 1084 1184878 SGTC_1822 st052468 42 µM 0.801275870449269 0.214962499931787 no 751 0.21148597835709 1039 2873678 SGTC_546 peri-Naphthalide 147 µM 0.800958623409635 0.215054071591458 no 752 0.211577799980484 1021 223824 A penicillin ester. SGTC_3095 9117207 49.47 µM 0.800321800502229 0.215237955463705 no 753 0.211762187696474 994 17015229 SGTC_945 3381-0768 11.3 µM 0.799249526872774 0.21554778268689 no 754 0.212072869564436 1078 1126236 YIL048W NEO1 SGTC_522 1273-0010 11.6 µM 0.798660891321656 0.215717975410743 no 755 0.212243534805285 1034 5705015 SGTC_387 norethindrone acetate 66.7 µM 0.79682805948349 0.216248402371441 no 756 0.212775448258509 987 541197 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.795169075069676 0.216729167808458 no 757 0.213257579065217 1010 1609 A potent and irreversible inhibitor of serine proteases. SGTC_860 0443-0016 25.1 µM 0.794107060089492 0.217037258698623 no 758 0.213566553929303 1099 5337942 SGTC_1428 4049-0204 61.7 µM 0.793478813961427 0.217219632183898 no 759 0.21374945398513 1082 X1428 SGTC_2738 aclarubicin 5.55 µM 0.791372704785835 0.21783165972423 no 760 0.214363266565335 961 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1783 st039459 87.517 µM 0.790682548392732 0.2180324327755 no 761 0.214564631193467 1107 729761 SGTC_1642 st009582 77.7 µM 0.790008419687331 0.218228646172751 no 762 0.214761425591291 1045 6739311 SGTC_1101 ebselen 5.29 µM 0.78991857622618 0.218254803891504 no 763 0.214787660978021 1135 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_886 0866-0150 153 µM 0.788963586057239 0.218532958736898 no 764 0.215066644826197 1104 271463 SGTC_1681 tripelennamine 100 µM 0.788743282585278 0.218597154305639 no 765 0.215131032525448 1018 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1454 4239-0054 42.6 µM 0.787744764280066 0.218888254711759 no 766 0.215423007944158 1102 1340767 SGTC_2018 5133068 143 µM 0.787455049340369 0.218972757716108 no 767 0.215507766113231 1005 785362 SGTC_3143 9086658 49.47 µM 0.787385033645521 0.218993182455363 no 768 0.215528252605082 1083 25236626 SGTC_2329 6138490 200 µM 0.787046749501401 0.219091880985034 no 769 0.215627249970754 931 720019 SGTC_2375 9072683 200 µM 0.786529383137794 0.219242878401234 no 770 0.215778705945823 1142 16798029 SGTC_2687 chenodiol 100 µM 0.786404210630966 0.219279419960471 no 771 0.21581535872647 1017 5702181 A cholesterol synthesis inhibitor. SGTC_57 miconazole 162.5 nM 0.78477902233536 0.219754178187908 no 772 0.216291570802548 1024 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_932 2857-0803 154 µM 0.783608942163306 0.220096352986019 no 773 0.216634803588255 1100 674898 SGTC_3117 9124945 49.47 µM 0.783282737456353 0.22019180177905 no 774 0.216730549017719 976 17592065 SGTC_1900 st060200 72.8 µM 0.783011952489644 0.220271052564022 no 775 0.216810046599931 1065 688945 SGTC_873 0591-4978 488 µM 0.782929582336544 0.220295163125696 no 776 0.216834232335184 1123 3305145 SGTC_696 1560-0013 611 µM 0.782415026797561 0.220445812885816 no 777 0.216985352753499 1077 1650269 SGTC_76 0433-0009 400.328 µM 0.78206020367092 0.220549731139058 no 778 0.217089596622866 948 2841569 SGTC_2569 tetrandrine 100 µM 0.78187741934844 0.22060327475593 no 779 0.217143308317086 972 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1382 3002-2117 298 µM 0.780606054505894 0.220975905853306 no 780 0.217517114859145 1114 1497314 SGTC_3162 9099653 49.47 µM 0.780025079106022 0.22114630689067 no 781 0.21768805675088 1048 25237511 SGTC_2143 5623677 140.463 µM 0.77874286566445 0.221522648132216 no 782 0.218065599900735 1063 5375313 SGTC_747 3448-8087 38.7 µM 0.776784179628396 0.22209824635125 no 783 0.218643056041453 1077 5168703 SGTC_2977 9011197 71.43 µM 0.776258407233321 0.222252900071532 no 784 0.218798212995721 999 2704722 SGTC_611 3453-1652 23.7 µM 0.773474024701913 0.223072938022499 no 785 0.219620947807163 1103 1560575 SGTC_1223 0764-0573 147 µM 0.770890318856824 0.223835412756665 no 786 0.220385972967544 1134 1609797 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.76583700168737 0.22533096536724 no 787 0.221886647306864 1079 4330530 SGTC_1980 st071811 45.7 µM 0.763788925021393 0.225938710771758 no 788 0.222496518868201 1093 4974850 SGTC_2357 9067248 200 µM 0.761867866721889 0.226509606186275 no 789 0.223069434996218 1063 9150235 SGTC_1855 st056195 39.6 µM 0.76014240515493 0.227023068180783 no 790 0.223584733769554 1059 4028379 SGTC_3287 9117173 37.0625 µM 0.759407292672225 0.227242021797828 no 791 0.223804476196086 1081 2789709 SGTC_3197 9113331 49.47 µM 0.758720474863649 0.227446698314456 no 792 0.224009893086745 1098 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1185 1319-0113 81.3 µM 0.758519970912773 0.22750646947193 no 793 0.224069881000017 1084 4672763 SGTC_1833 st055984 71 µM 0.757283186008931 0.227875356301048 no 794 0.224440111028214 1085 676288 SGTC_2417 cerulenin 830 nM 0.756659794601527 0.228061418208985 no 795 0.224626853988077 1093 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_149 3970-0822 46.1 µM 0.755894518700441 0.228289944766334 no 796 0.224856220293215 1172 3114250 YBL034C STU1 SGTC_203 k066-0004 30.888 µM 0.755779099317763 0.228324422448972 no 797 0.224890824979907 1199 6795412 SGTC_2416 tofa 880 nM 0.752909983271925 0.229182414942079 no 798 0.225752004288399 1025 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_622 1348-1566 26.3 µM 0.752083993052654 0.229429757304844 no 799 0.226000274701673 1152 7340407 SGTC_182 3448-4371 550.524 µM 0.751276823437623 0.229671608313009 no 800 0.226243037192853 1139 3491403 SGTC_1128 3448-9350 235 µM 0.750866336008493 0.229794656793512 no 801 0.226366550945818 1038 619386 SGTC_862 0452-0056 10.2 µM 0.7499825387689 0.230059710763434 no 802 0.226632610641595 1076 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_206 4546-0025 72.014 µM 0.74948408194045 0.23020927517531 no 803 0.226782744671326 1145 6620745 YIL048W NEO1 SGTC_1801 st050089 28.441 µM 0.748959216304238 0.23036682244785 no 804 0.226940893607148 1162 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2256 7954252 200 µM 0.748184216120784 0.230599562009194 no 805 0.227174525066718 1047 2972920 SGTC_787 4152-0075 138 µM 0.745974249540455 0.231263955959527 no 806 0.227841485256858 1079 9566539 SGTC_1121 fusaric acid 630.51 nM 0.745241610495377 0.231484448567067 no 807 0.228062836109177 1084 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1687 st020778 55.3625 µM 0.743995143026631 0.231859850455407 no 808 0.22843970674179 1161 4259299 SGTC_3002 9075603 71.4286 µM 0.743838450273421 0.231907066005547 no 809 0.228487107691672 1139 20105405 SGTC_2263 7948595 193.29 µM 0.743720655599781 0.231942564091021 no 810 0.228522745264926 1043 2971371 SGTC_1154 4088-0362 150 µM 0.743339548774944 0.232057433498956 no 811 0.22863806662581 1169 6618304 SGTC_1379 2144-0755 36.5 µM 0.742665894963768 0.23226055694066 no 812 0.22884199142239 1173 5392327 SGTC_2823 7987624 58.44 µM 0.742408713629989 0.232338129619156 no 813 0.228919870867568 1113 2239440 SGTC_67 0335-0847 266 µM 0.741485152691467 0.232616818755862 no 814 0.229199665424595 1175 4552207 YOR254C SEC63 SGTC_3099 9120367 49.47 µM 0.741386600809387 0.232646568248764 no 815 0.229229533225821 1146 24824940 SGTC_157 1348-1695 65.819 µM 0.741234823170805 0.232692388940712 no 816 0.229275536254087 1123 5380510 SGTC_2125 5246583 200 µM 0.74034357965601 0.232961550797929 no 817 0.229545772031218 1175 835267 SGTC_459 nigericin 15.3 µM 0.738089695276687 0.233643010868092 no 818 0.230229972631401 1199 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2484 5809818 12.04 µM 0.736944420073551 0.233989706911634 no 819 0.230578074783036 1086 2870548 SGTC_3319 9138450 16.7555 µM 0.736922035973022 0.233996485832135 no 820 0.230584881276546 1088 2029690 SGTC_521 r062-0005 13.8 µM 0.736342539686043 0.23417202144104 no 821 0.230761131930513 1077 2832033 SGTC_3211 9128781 49.47 µM 0.735971327787912 0.234284503785698 no 822 0.230874073545333 1044 17194361 SGTC_2296 7971656 126.45 µM 0.733103323690783 0.235154556101304 no 823 0.23174770656177 1151 666570 SGTC_2111 5486399 200 µM 0.732539979118626 0.235325664611523 no 824 0.231919525140259 1170 689674 SGTC_2257 7960413 200 µM 0.732224102199334 0.235421638140091 no 825 0.232015897783731 1142 2974689 YIL048W NEO1 SGTC_1187 1391-0724 117 µM 0.731978422683662 0.235496298380077 no 826 0.232090868923855 1153 6997986 SGTC_2032 5185112 25.99 µM 0.731926097130911 0.235512201427113 no 827 0.232106838241651 1082 5718189 SGTC_890 0929-0006 47.2 µM 0.731442463597529 0.235659217825765 no 828 0.232254468069388 1135 1378169 SGTC_66 0109-0187 42.4 µM 0.730275391743813 0.236014196254647 no 829 0.232610933496313 1080 759417 SGTC_1376 2910-0861 41.3 µM 0.727730059926429 0.23678940947729 no 830 0.233389422723891 1148 1112859 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.727527055970963 0.236851297151977 no 831 0.233451573622137 1186 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2220 6782180 200 µM 0.727414656183491 0.236885567114589 no 832 0.233485989450658 1088 833803 SGTC_878 0828-0289 13.7 µM 0.725236384353719 0.237550246052997 no 833 0.234153512616769 1115 745350 YLR208W SEC13 SGTC_3231 9132313 49.47 µM 0.724982538300106 0.237627771298986 no 834 0.234231371468578 1129 4905967 SGTC_75 0159-0059 199.013 µM 0.724090716366249 0.237900246071394 no 835 0.234505021840255 1143 5377270 SGTC_1303 1160-0052 261 µM 0.723622156983261 0.238043471756069 no 836 0.23464886740211 1178 3562476 SGTC_900 1112-0045 141 µM 0.720944396651816 0.238862895397579 no 837 0.235471862944857 1069 56211 YIL048W NEO1 SGTC_3003 9075612 71.4286 µM 0.720628303075328 0.238959725153089 no 838 0.235569117642058 1141 6501993 SGTC_1752 st044819 83.042 µM 0.720592222402752 0.238970779202604 no 839 0.235580220241086 1130 441209 YML126C ERG13 SGTC_2879 9041815 71.43 µM 0.720265029167228 0.239071034282574 no 840 0.23568091600102 1110 4942971 SGTC_765 1319-0117 244 µM 0.719189263684753 0.239400820931931 no 841 0.236012156808124 1145 3487746 YGL099W LSG1 SGTC_3311 9131146 2.8755 µM 0.71837017671972 0.239652086730191 no 842 0.236264535214249 1112 4900406 YPR165W RHO1 SGTC_1631 benzylvanillin 81.9 µM 0.718112498213556 0.239731162784414 no 843 0.236343962254197 1146 75506 SGTC_514 4466-0038 2.65 nM 0.717678917680494 0.23986425155795 no 844 0.236477642656309 1129 5722064 SGTC_174 3553-0389 74.3 µM 0.717046024368587 0.240058592283337 no 845 0.236672849330632 1143 738071 SGTC_1106 tegaserod maleate 11.7 µM 0.716451137551043 0.240241340702613 no 846 0.236856414244742 1172 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_518 1021-0119 62.6 µM 0.715009410722501 0.240684551548826 no 847 0.237301614134824 1112 1097762 SGTC_295 k015-0027 31 µM 0.714857568881017 0.240731256150653 no 848 0.237348529065753 1155 3887424 SGTC_2920 7982904 15.77 µM 0.712835199119553 0.241353781206096 no 849 0.237973870818868 1135 6456808 SGTC_2848 9016370 25.97 µM 0.70771654296246 0.242933304790141 no 850 0.239560651055374 1190 7894410 SGTC_3277 9138724 49.47 µM 0.707612879938582 0.242965350975341 no 851 0.239592846091339 1068 15943418 SGTC_871 0574-0004 149 µM 0.705862072818656 0.243506937391717 no 852 0.240136957839181 1137 9551173 SGTC_1383 3049-0032 20.7 µM 0.705358604952593 0.243662798405194 no 853 0.2402935490059 1204 712864 SGTC_3054 9094397 49.47 µM 0.705162783428685 0.243723434380253 no 854 0.240354469448587 1184 2598354 SGTC_883 0850-0245 24.6 µM 0.702864453279534 0.244435718937236 no 855 0.241070112767216 1195 6823229 YPR165W RHO1 SGTC_13 0199-0087 65 µM 0.701893675185699 0.244736913195859 no 856 0.241372736788298 1206 4589825 SGTC_2472 5377652 49.4 µM 0.701889022338888 0.244738357272183 no 857 0.241374187733175 1193 1610903 SGTC_3106 9121286 49.47 µM 0.701763677330818 0.24477726158136 no 858 0.241413277134082 1211 15943471 SGTC_115 0527-0192 112.043 µM 0.701623245189048 0.244820852556085 no 859 0.241457075609324 1215 4233931 SGTC_2614 arthonioic acid 13.39 µM 0.700690395437564 0.245110520720321 no 860 0.241748125632935 1154 6710684 SGTC_834 0312-0008 75.7 µM 0.700504324198425 0.245168321536385 no 861 0.241806202808675 1201 6385573 YIL048W NEO1 SGTC_1366 1683-0113 21.9 µM 0.700469310412262 0.245179198971704 no 862 0.241817132274739 1201 708623 SGTC_1908 st060353 56.5 µM 0.700100053566802 0.245293928655001 no 863 0.241932411197378 1211 4227716 SGTC_1113 artemisinin 1.17947 µM 0.699942475725881 0.24534289754934 no 864 0.241981614765567 1194 2240 An anti-malaria and mitochondrial poison. SGTC_614 0462-0418 107 µM 0.699616625741215 0.245444175364451 no 865 0.242083378404657 1088 5188303 SGTC_1170 0310-0127 64.8 µM 0.696853397363569 0.246303919879758 no 866 0.242947272524889 1178 774975 SGTC_35 0133-0054 64.071 µM 0.696485903120972 0.246418382700702 no 867 0.243062291235402 1150 99677 SGTC_911 3456-4043 236 µM 0.69629147020983 0.246478953925465 no 868 0.243123156950044 1234 914281 SGTC_2003 4023581 200 µM 0.695268312211625 0.24679782732141 no 869 0.243443584377639 1205 16641307 SGTC_1930 st074634 34.3 µM 0.692832156522698 0.247557958112876 no 870 0.244207444749572 1174 684253 YOR116C RPO31 SGTC_61 0978-8327 98.565 µM 0.692083878615944 0.247791687080338 no 871 0.244442327591225 1230 6150059 YHR072W ERG7 SGTC_2803 7707263 71.43 µM 0.69183240021893 0.247870264266708 no 872 0.244521293444449 1185 2199229 SGTC_1939 st074455 53.6 µM 0.690639862678453 0.248243066727431 no 873 0.244895945013143 1217 1644229 SGTC_2594 a-mangostin 100 µM 0.690256534328477 0.24836296353071 no 874 0.245016438299768 1219 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.690142163583269 0.24839874219993 no 875 0.245052395135743 1244 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.69012158487218 0.248405180142142 no 876 0.245058865145161 1254 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_590 k048-0076 22.4 µM 0.689972661816182 0.248451772592279 no 877 0.245105689745822 1195 6832814 SGTC_287 k060-0039 29.6 µM 0.688989216854981 0.248759572602425 no 878 0.24541502669614 1222 5861974 SGTC_1435 4092-0789 56.7 µM 0.687047744035768 0.249367813121776 no 879 0.246026321183166 1224 2248285 SGTC_1846 st056244 14.8 µM 0.686058008008663 0.249678189695939 no 880 0.246338264747442 1205 5393182 SGTC_393 acivicin 6.25 µM 0.685802635345983 0.249758306650938 no 881 0.246418787127816 1126 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1427 4048-4900 550 nM 0.685361201309482 0.249896828017657 no 882 0.246558010380669 1206 24132586 SGTC_3175 9106517 49.47 µM 0.684150647321241 0.250276907271522 no 883 0.246940021406552 1205 41468073 SGTC_1803 st050068 52.4 µM 0.681254365584733 0.251187499199452 no 884 0.247855276628527 1307 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2814 7977482 42.97 µM 0.679552647003647 0.251723336135898 no 885 0.24839388077866 1253 6456762 SGTC_324 1315-0088 19.6 µM 0.679282831015449 0.251808351167838 no 886 0.248479336420684 1178 6787421 SGTC_1064 honokiol 6.76 µM 0.678709741228566 0.251988973573327 no 887 0.248660896366964 1223 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2582 agaric acid 100 µM 0.677063014425512 0.252508357557538 no 888 0.249182987040049 1159 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2621 lithochol-11-enic acid 100 µM 0.674621823563877 0.253279355252693 no 889 0.249958032047286 1224 6708711 SGTC_824 1304-0008 100 µM 0.674110195976161 0.253441098577135 no 890 0.250120628876423 1239 768245 SGTC_1080 nisoldipine 24.4 µM 0.673737187375549 0.253559053809056 no 891 0.250239207516504 1213 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3127 9126946 49.47 µM 0.673539127723777 0.253621697254707 no 892 0.250302182372727 1171 27243249 SGTC_129 0088-0017 176.636 µM 0.673262889752809 0.253709080962286 no 893 0.250390028762079 1162 182446 SGTC_2292 7671323 168.05 µM 0.672816387367708 0.253850358667876 no 894 0.250532055456213 1224 937504 SGTC_2434 5670830 169.91 µM 0.67238463024924 0.253987010089236 no 895 0.250669432452555 1223 1549830 SGTC_3155 9099265 49.47 µM 0.66950177731576 0.254900423340523 no 896 0.251587723669183 1194 25236499 SGTC_2834 9001755 58.44 µM 0.669151537101883 0.255011511680927 no 897 0.251699408581241 1173 2989575 SGTC_976 1348-1067 47.6 µM 0.668896626632311 0.255092379487667 no 898 0.251780711119587 1283 5310671 YGL099W LSG1 SGTC_290 2043-6722 48.1 µM 0.667882976467644 0.255414082574437 no 899 0.252104147391553 1237 773758 YLR208W SEC13 SGTC_1450 4112-4260 37.6 µM 0.664534187810131 0.256478396020111 no 900 0.253174237603482 1232 1633175 SGTC_3326 9140064 16.379 µM 0.664302246268404 0.256552197244968 no 901 0.253248441825315 1231 1868434 SGTC_3265 9137266 49.47 µM 0.663178453946041 0.25690993206235 no 902 0.253608134526096 1202 17224265 SGTC_2820 7989630 71.43 µM 0.662382313267932 0.257163523096743 no 903 0.253863117923562 1151 2984098 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.662239596514064 0.257208995761921 no 904 0.253908840650874 1228 75037 A free radical scavenger. SGTC_1460 k062-0059 9.15 µM 0.662123685969224 0.257245930461235 no 905 0.253945978547918 1216 1373085 SGTC_613 3914-0030 117 µM 0.66192462182011 0.257309368348855 no 906 0.254009765624335 1059 1145395 SGTC_2307 7538926 6.34 µM 0.661734059735133 0.257370104409765 no 907 0.254070836218391 1255 96582 SGTC_1560 lithocholic acid 53.1 µM 0.6575918773065 0.258692141838168 no 908 0.255400207689714 1206 9903 A bile acid which acts as a detergent. SGTC_199 4063-0024 41.6 µM 0.653383575945095 0.260038873105395 no 909 0.256754512212483 1281 306215 SGTC_2211 7117706 200 µM 0.650899153052322 0.260835626280279 no 910 0.257555794107964 1218 822771 SGTC_1766 st045414 44.774 µM 0.649415095974518 0.261312161062006 no 911 0.25803505454314 1301 253960 SGTC_1947 st076332 61.6 µM 0.647376078309179 0.261967623794455 no 912 0.258694287110632 1256 24208416 SGTC_1928 4'-methoxychalcone 40.3 µM 0.645041286947779 0.262719199835504 no 913 0.25945021524942 1321 641818 SGTC_3237 9133362 49.47 µM 0.644546239238802 0.262878698732574 no 914 0.259610641782837 1240 43845137 SGTC_2913 7966556 36.57 µM 0.643876670958004 0.26309450497211 no 915 0.259827705384129 1243 2976516 SGTC_795 0685-0265 78 µM 0.642691724096135 0.263476642846596 no 916 0.260212076050251 1314 302754 SGTC_3075 9116269 49.47 µM 0.637174037989967 0.265259785024184 no 917 0.262005743288246 1310 17015205 YNL244C SUI1 SGTC_782 0083-0095 30.5 µM 0.636109508454533 0.265604511108609 no 918 0.262352524232068 1292 3591729 An indicator and reagent. SGTC_426 0988-0037 14.6 µM 0.635180253641168 0.26590561686989 no 919 0.262655430141378 1292 5383008 SGTC_1253 0550-0034 176 µM 0.633096728267404 0.266581368170578 no 920 0.263335239344408 1281 5969915 SGTC_3169 9102970 49.47 µM 0.633037742835386 0.266600511591297 no 921 0.26335449808285 1348 17027839 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.632719087456618 0.266703941586437 no 922 0.263458551471681 1306 2724 A muscle relaxant with antifungal properties. SGTC_2482 5981709 142.65 µM 0.632525075074995 0.266766924564678 no 923 0.263521914345079 1294 877755 SGTC_1628 st004252 77.7 µM 0.631684820262886 0.267039786430936 no 924 0.26379642451531 1313 692968 SGTC_2506 ethyl hematommate 54.16 µM 0.631291470009386 0.267167570243935 no 925 0.263924981628914 1252 3940691 An allergen. SGTC_1992 st073643 23.3 µM 0.629829140553077 0.267642893281547 no 926 0.26440318888328 1277 3161292 SGTC_418 lividomycin a 100 µM 0.6274035422184 0.268432260924429 no 927 0.265197373203052 1299 72394 An antibiotic. SGTC_2079 5212404 121 µM 0.625624307996689 0.269012024266244 no 928 0.265780695509995 1326 758462 SGTC_1768 st044301 37.178 µM 0.622764885005773 0.269945081864146 no 929 0.26671951849187 1296 3931349 SGTC_665 3914-0008 307 µM 0.622114707242796 0.270157467005226 no 930 0.266933222434839 1267 1069549 SGTC_1638 st008370 60.6 µM 0.621504750181953 0.270356789724498 no 931 0.267133785021419 1301 24207134 SGTC_86 0417-1630 471.922 µM 0.621391350457514 0.270393854765306 no 932 0.267171080853805 1322 3634867 SGTC_2709 st078560 56 µM 0.620107699017346 0.270813597106709 no 933 0.267593441863576 1336 17250903 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.618930325522815 0.271198873279128 no 934 0.267981129871317 1172 4000243 SGTC_2849 9019321 12.99 µM 0.618853291653441 0.271224090871387 no 935 0.268006505599109 1311 16489627 SGTC_122 0236-0016 402.397 µM 0.618688875211219 0.271277917688315 no 936 0.26806067006759 1344 6808838 SGTC_1072 oxiconazole 14.9 nM 0.615479846801809 0.27232955748191 no 937 0.269118937276483 1327 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2533 agelasine 13.65 µM 0.61337622175503 0.273020039719488 no 938 0.269813802424867 1374 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_106 0092-0003 11.579 µM 0.612004589666464 0.273470723595308 no 939 0.270267360475201 1321 1072148 SGTC_515 4092-1064 102 µM 0.611876072891385 0.273512969844334 no 940 0.270309876685543 1390 717353 SGTC_2777 climbazole 1.536 µM 0.61106770655735 0.273778771413597 no 941 0.270577378902307 1322 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1183 1254-0324 198 µM 0.610940446037747 0.273820627995563 no 942 0.270619503624614 1362 5799357 SGTC_1093 fluphenazine 7.97 µM 0.610536487864832 0.273953512694422 no 943 0.270753240207415 1365 6602611 An atypical antipsychotic. SGTC_1163 k060-0048 49.9 µM 0.609751280016631 0.274211903145646 no 944 0.271013289741513 1322 6809982 SGTC_1229 0139-0193 12.2 µM 0.60705225209922 0.275100996380552 no 945 0.271908118060687 1362 3090752 SGTC_379 3970-0972 5.9 µM 0.607012274882455 0.275114176033694 no 946 0.271921383035558 1343 2898042 YBL034C STU1 SGTC_3354 9151612 71.43 µM 0.606561155182559 0.27526292232279 no 947 0.27207109288996 1342 27261949 SGTC_16 erodoxin 22.806 µM 0.606333160641278 0.275338113307077 no 948 0.272146771387722 1352 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2331 7980721 200 µM 0.606126116771832 0.275406403664366 no 949 0.272215504768882 1326 2981221 SGTC_2558 carylophyllene oxide 100 µM 0.606120907100172 0.275408122104968 no 950 0.27221723436071 1382 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2031 5180455 200 µM 0.605326557107746 0.275670204796865 no 951 0.272481019522558 1287 29949 SGTC_478 N-arachidonylglycine 10 µM 0.602933417985784 0.27646052194184 no 952 0.273276491815635 1283 5283389 SGTC_196 k015-0023 18.111 µM 0.60281441967302 0.276499849265225 no 953 0.273316076500593 1330 5211998 SGTC_1022 4477-0945 21.3 µM 0.602525460517839 0.276595357750456 no 954 0.273412210330558 1329 4648966 SGTC_1151 3909-8316 15.3 µM 0.602165874071129 0.276714232962463 no 955 0.273531864531488 1335 800431 SGTC_1667 st014849 34.6 µM 0.600037550446828 0.277418344798145 no 956 0.274240605158301 1358 5348460 SGTC_918 glabranin 770.725 nM 0.599581566223945 0.277569311593068 no 957 0.274392567679303 1398 124049 Also referred to as licorice root. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.599407598104869 0.277626919359214 no 958 0.274450555711492 1394 688788 SGTC_3012 9080433 71.4286 µM 0.598589507500115 0.277897899999857 no 959 0.274723327337414 1348 17688859 SGTC_493 zm226600 134 µM 0.597791200959155 0.278162451852501 no 960 0.274989631269951 1371 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1974 st069448 26.9 µM 0.597327152403381 0.27831628994177 no 961 0.275144489827601 1330 6323587 YNR016C ACC1 SGTC_964 1287-0107 19.4 µM 0.596676563304021 0.278532038436682 no 962 0.275361671478754 1406 51516812 YPR165W RHO1 SGTC_2110 5483698 200 µM 0.596502324099358 0.278589833506601 no 963 0.275419850863522 1344 2848765 YHR062C RPP1 SGTC_1345 1488-0192 31.4 µM 0.596060574465465 0.278736387841401 no 964 0.275567380482258 1347 658348 SGTC_592 k241-0073 46.5 µM 0.595108587816018 0.279052345332154 no 965 0.275885444271189 1387 4230158 SGTC_108 0509-0257 621.132 µM 0.595083804002389 0.279060573226403 no 966 0.2758937270829 1315 536624 SGTC_142 0335-0849 62.6745 µM 0.594328621153916 0.279311340367861 no 967 0.276146169611962 1384 3889043 YPR107C YTH1 SGTC_2742 clothiapine 36.27 µM 0.593998222250909 0.279421087539944 no 968 0.276256651002953 1343 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2146 5545642 200 µM 0.593722432938002 0.27951271131645 no 969 0.276348888213622 1356 825326 SGTC_1319 1306-0155 43.7 µM 0.593390312789188 0.279623068896651 no 970 0.276459985211825 1375 3122360 SGTC_1781 st038725 66.3 µM 0.593119640513835 0.279713024087597 no 971 0.276550543571773 1359 4270275 YIL048W NEO1 SGTC_2784 7567673 72.73 µM 0.590168357505806 0.280694763362958 no 972 0.277538891898363 1362 3471247 SGTC_2504 purpurogallin 52.29 µM 0.589968649015282 0.280761256213704 no 973 0.277605834114554 1332 5281571 An antioxidant. SGTC_1509 1326-1131 80 µM 0.589379491276733 0.280957460384451 no 974 0.277803365534108 1322 768313 SGTC_1126 isoteolin 1.0172 µM 0.589321025401768 0.280976934587676 no 975 0.277822971577466 1321 133323 SGTC_2508 celastrol 40.54 µM 0.588788998999544 0.281154175456251 no 976 0.278001413230093 1305 122724 Celastrol is a natural product and antioxidant. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.587668212134068 0.281527734350438 no 977 0.278377508038805 1374 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2669 eugenol 100 µM 0.587263808802867 0.281662580964414 no 978 0.278513271759926 1358 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_952 1185-0122 232 µM 0.586287118387633 0.281988382708261 no 979 0.278841293027807 1295 678600 SGTC_31 0508-1974 57.237 µM 0.585577507610508 0.282225206541019 no 980 0.279079733511231 1328 6810525 SGTC_2084 5306078 60.6385 µM 0.583197701117779 0.283020135634694 no 981 0.27988010928382 1358 679340 SGTC_2269 7935389 174.42 µM 0.583035931233949 0.283074210776239 no 982 0.279934556063811 1334 97605 SGTC_2063 5246145 200 µM 0.582718570870126 0.283180309861197 no 983 0.280041384745086 1405 711240 SGTC_1075 aripiprazole 15.2 µM 0.582358219036132 0.283300804867397 no 984 0.280162709010826 1370 60795 An atypical antipschotic. YIL048W NEO1 SGTC_366 0181-0206 4.31 µM 0.58176404758149 0.283499538520962 no 985 0.280362811923486 1427 274874 SGTC_3350 9150499 3.57 µM 0.579887280311976 0.284127702864813 no 986 0.280995316958981 1321 4910996 YPR165W RHO1 SGTC_1643 st009866 20.2 µM 0.578302704611239 0.284658586815014 no 987 0.281529884371926 1366 3156273 YOR207C RET1 SGTC_2905 7799065 20.05 µM 0.577198742812681 0.285028729281952 no 988 0.281902603119427 1357 1296806 SGTC_9 0092-0002 10.449 µM 0.576951327990692 0.285111715371616 no 989 0.281986167723656 1368 759368 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.576537438894668 0.285250564800999 no 990 0.282125985849098 1358 115019 SGTC_2715 st079500 56.4 µM 0.575821645897758 0.285490771442813 no 991 0.282367870517255 1329 28246688 SGTC_14 0354-0009 295 µM 0.575590247678722 0.285568444917104 no 992 0.282446087196546 1406 1713507 SGTC_352 k048-0007 5.11 µM 0.574223819416853 0.286027319033247 no 993 0.282908176362506 1350 6811911 SGTC_1493 4348-0038 111 µM 0.573981336281265 0.286108786345115 no 994 0.282990215526605 1416 800424 SGTC_3348 9149464 3.537 µM 0.573869484351344 0.286146369069594 no 995 0.28302806216721 1361 1951442 SGTC_1021 4476-0760 85.3 µM 0.573189939632051 0.28637474937585 no 996 0.283258047682996 1342 746768 SGTC_2126 5251174 33.877 µM 0.572358104632584 0.286654428876613 no 997 0.283539696371939 1479 790722 SGTC_2926 9010726 65.15 µM 0.572077624190608 0.28674876118135 no 998 0.283634693705115 1345 2994293 SGTC_1942 st076330 65.2 µM 0.571545526177532 0.286927758944284 no 999 0.283814954547733 1409 24208414 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.571331277291127 0.286999847212167 no 1000 0.283887551932729 1433 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1711 st032263 62.8 µM 0.566867358879796 0.288503768513748 no 1001 0.285402151112854 1406 3958979 SGTC_583 1488-1091 88.9 µM 0.566469006560972 0.288638156126737 no 1002 0.285537498117386 1458 4303273 SGTC_3126 9127922 49.47 µM 0.564655170472117 0.289250441962881 no 1003 0.286154165877902 1410 45595682 SGTC_2991 9074669 71.4286 µM 0.563226307226363 0.289733204287898 no 1004 0.286640395654927 1460 17333109 SGTC_11 0438-0307 1.3 µM 0.56320979640048 0.289738784920742 no 1005 0.286646016435013 1449 4011476 SGTC_612 0302-0167 22.4 µM 0.562412573247759 0.29000830507238 no 1006 0.286917477267153 1467 235821 SGTC_470 aa-861 153 µM 0.56022893522389 0.290747136815186 no 1007 0.287661646460425 1352 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1438 4092-1045 4 µM 0.559555059752388 0.290975319503582 no 1008 0.287891482748118 1380 1351342 SGTC_2552 juarezic acid 87.02 µM 0.55837131397764 0.291376353138465 no 1009 0.288295428495236 1418 1549512 SGTC_524 r073-0010 27.8 µM 0.557840174081226 0.291556378396767 no 1010 0.288476763448736 1348 2772106 SGTC_2886 9058944 51.95 µM 0.557641420894295 0.291623757397558 no 1011 0.288544633024186 1313 4949929 SGTC_2659 sanguinarine 24.21 µM 0.555063938885902 0.292498202215186 no 1012 0.289425463653357 1363 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1916 st067606 49.2 µM 0.554965629805321 0.292531578983444 no 1013 0.289459084864782 1481 19590279 SGTC_156 3474-0145 5.642 µM 0.554886055837139 0.292558596317897 no 1014 0.289486300105246 1370 2265471 SGTC_3219 9131112 49.47 µM 0.554560296485361 0.292669211779323 no 1015 0.289597726193636 1360 17612988 YMR079W SEC14 SGTC_1573 oleylamine 1.06 µM 0.553143788262381 0.293150429738595 no 1016 0.290082477258481 1406 5356789 An amine of the fatty acid oleic acid. SGTC_312 4092-0653 6.84 µM 0.550734443217168 0.293969777163613 no 1017 0.290907864887167 1451 1148278 SGTC_452 diindolylmethane 8 µM 0.550019778771772 0.294213017001253 no 1018 0.291152903817002 1411 3071 Inhibits expression of several cancer promoting factors. SGTC_1267 0828-0272 9.49 µM 0.549728108783943 0.294312315140194 no 1019 0.291252937181144 1498 745334 SGTC_2176 5809774 33.9695 µM 0.547643927547205 0.295022318159944 no 1020 0.291968210355615 1416 2870539 SGTC_3017 9080681 49.47 µM 0.546488265369735 0.295416349024192 no 1021 0.292365175922388 1394 16451914 SGTC_1191 1487-1166 10.6 µM 0.54622014722419 0.295507800312799 no 1022 0.292457309341134 1513 3955771 SGTC_2486 5283202 22.39 µM 0.545085350548535 0.295895007410816 no 1023 0.292847408804705 1358 1377751 SGTC_1862 st057513 3.81 µM 0.54498053554187 0.295930783378984 no 1024 0.292883452356054 1393 5393163 SGTC_1701 st028638 40.4 µM 0.541761487591674 0.297030490306039 no 1025 0.293991412684025 1490 3490878 SGTC_2748 diazoxide 86.69 µM 0.541265525469104 0.297200089351284 no 1026 0.294162289441253 1425 3019 A potassium channel activatior. SGTC_107 0358-0022 2.6945 µM 0.539676027220528 0.297743931666496 no 1027 0.294710237632365 1485 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2619 obliquin 87.91 µM 0.538944294414907 0.297994444480728 no 1028 0.29496264621997 1440 6708593 A bioactive alkalod. YER133W GLC7 SGTC_861 0443-0273 110 µM 0.538796345935574 0.298045107142401 no 1029 0.295013692616533 1449 6149169 SGTC_1195 1502-0147 41.1 µM 0.536895224076381 0.298696465795287 no 1030 0.295669995082371 1413 817940 SGTC_424 splitomicin 100 mM 0.535675650189805 0.299114654251523 no 1031 0.29609136756149 1390 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_799 1310-0557 151 µM 0.535673379050345 0.299115433266729 no 1032 0.296092152515259 1444 5354492 SGTC_3031 9088762 49.47 µM 0.535624591679474 0.299132167866027 no 1033 0.296109014691724 1372 205253 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.531624128132012 0.300505813875948 no 1034 0.29749317509996 1502 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1305 1181-0477 144 µM 0.531192006119473 0.300654362683896 no 1035 0.297642865951725 1508 6252086 SGTC_3257 9139206 32.98 µM 0.530891533134031 0.300757674579891 no 1036 0.297746972682962 1425 4910041 SGTC_2461 5755302 26.15 µM 0.530484241488567 0.300897739597693 no 1037 0.297888116048039 1535 2788904 SGTC_2446 5162541 200 µM 0.529979089485735 0.301071499028866 no 1038 0.298063214435377 1388 1549321 SGTC_2199 6590217 200 µM 0.529168222156646 0.301350511265056 no 1039 0.298344379459119 1463 703109 SGTC_685 1278-0033 54.9 µM 0.527592200663814 0.301893138980458 no 1040 0.298891203721911 1510 3590572 SGTC_1828 st055811 49 µM 0.527553601156593 0.301906434383345 no 1041 0.298904602109814 1426 5877589 SGTC_147 4466-0538 29.23 µM 0.52702961779338 0.302086943792613 no 1042 0.299086510493146 1485 6742687 YHR072W ERG7 SGTC_1851 st056236 18.9 µM 0.525565632971366 0.30259153521606 no 1043 0.299595020113289 1485 5393171 SGTC_1515 3460-0031 42.1 µM 0.525350890253258 0.30266558231226 no 1044 0.299669643124778 1403 2876596 SGTC_933 2914-0560 114 µM 0.525103662919021 0.302750840732057 no 1045 0.299755564953435 1572 463887 SGTC_179 1273-0063 6.77 µM 0.524271174118094 0.303038010539849 no 1046 0.300044971597417 1412 3108139 SGTC_773 4358-1457 44.6 µM 0.523608127628846 0.303266817803339 no 1047 0.300275563658929 1563 1186886 SGTC_1767 st044992 70.3 µM 0.523476563822157 0.303312227653866 no 1048 0.300321327996324 1385 9600693 SGTC_417 st075190 100 µM 0.523174394656975 0.303416534229258 no 1049 0.300426449167456 1535 222757 SGTC_534 k292-0788 63.4 µM 0.522646808429421 0.303598691525971 no 1050 0.300610030174675 1504 4146317 SGTC_489 paxilline 115 µM 0.521961977001343 0.303835212952856 no 1051 0.300848402353981 1386 105008 A toxic potassium channel blocker. SGTC_1861 st057647 17.4 µM 0.521890156093485 0.303860022626866 no 1052 0.300873406300836 1553 688668 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.520044139205361 0.304498016916976 no 1053 0.301516405540911 1432 16486 A toxic proline analog. SGTC_2935 9038016 29.96 µM 0.519925307821225 0.304539106155143 no 1054 0.301557817717509 1435 6463195 SGTC_2124 5246320 200 µM 0.519528533571812 0.304676319693261 no 1055 0.301696110203177 1473 579342 SGTC_2865 9030313 51.95 µM 0.519258846388992 0.30476959933065 no 1056 0.301790123785738 1401 42562754 SGTC_1550 gossypolone 36.6 µM 0.518589189031652 0.305001275878329 no 1057 0.30202362483242 1437 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1872 amphotericin b 148 nM 0.518466394090356 0.305043766847593 no 1058 0.302066450676382 1491 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3303 9125618 40.5795 µM 0.517741454961027 0.305294672475027 no 1059 0.302319335288032 1536 22695467 SGTC_2278 7948257 134.34 µM 0.515762465656531 0.305980077753101 no 1060 0.30301016032844 1480 1247028 SGTC_413 propylparaben 100 µM 0.514347997721435 0.306470382941649 no 1061 0.303504354836876 1413 7175 A pharmaceutical preservative. SGTC_2025 5147754 141 µM 0.511854713545654 0.307335488164887 no 1062 0.304376347353399 1501 315777 YLR208W SEC13 SGTC_2183 6420625 130.508 µM 0.511506468470504 0.307456405728381 no 1063 0.304498230091609 1442 2897619 SGTC_1741 st038134 10.228 µM 0.510324843531716 0.307866845144337 no 1064 0.304911950273838 1585 1272587 SGTC_1122 capsaicin 818.572 nM 0.509871084180353 0.308024523161283 no 1065 0.305070890546579 1561 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2518 prenyletin 46.28 µM 0.509308740222659 0.308219982707139 no 1066 0.305267916252037 1428 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2164 5685496 200 µM 0.507805639420078 0.308742697458929 no 1067 0.305794827247089 1482 759046 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.507613871011633 0.308809414293134 no 1068 0.305862080494493 1465 140250 A respiratory chain inhibitor. SGTC_1204 4049-0315 18.3 µM 0.50707541822234 0.30899677744289 no 1069 0.306050951068261 1575 588402 SGTC_2932 9016711 44.54 µM 0.505962253406668 0.30938427827183 no 1070 0.306441574179625 1572 7117328 SGTC_2778 tioconazole 65.09 nM 0.504287441640725 0.309967692004917 no 1071 0.307029700575254 1428 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_43 0570-0105 72.5 µM 0.503989310408904 0.310071595028855 no 1072 0.307134444386697 1525 1114046 YDL195W SEC31 SGTC_1037 k284-1091 78.7 µM 0.503633401137982 0.310195654392379 no 1073 0.307259508231228 1448 3334711 SGTC_2208 7283366 200 µM 0.503505868931353 0.310240113576885 no 1074 0.307304327547413 1548 898663 SGTC_1587 estradiol valerate 56.1 µM 0.503357797329607 0.310291736508751 no 1075 0.30735636874224 1502 13791 A steroid. SGTC_465 cgp-37157 41 µM 0.501591304757252 0.310907885586018 no 1076 0.307977518553277 1483 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1309 pyrazolanthrone 13.4 µM 0.499902821448738 0.311497321174804 no 1077 0.308571752755548 1575 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_363 0455-0021 3.06 µM 0.499579644689392 0.311610194683174 no 1078 0.308685546804865 1496 4597466 SGTC_896 0964-0007 44.5 µM 0.498492189494675 0.311990131923082 no 1079 0.30906858647775 1475 6756758 SGTC_404 fumagillin 50 µM 0.498166406152844 0.312103993723312 no 1080 0.309183379188167 1497 12015870 A methionine aminopeptidase binder. SGTC_1164 k060-0068 93.7 µM 0.497961679398697 0.312175555238367 no 1081 0.309255526047426 1509 5963676 SGTC_1102 cgs 12066b 26.1 µM 0.497516100463203 0.312331330280294 no 1082 0.309412575992235 1475 6438352 A 5-HT1B full agonist. SGTC_2087 5276107 200 µM 0.496287082027074 0.312761170730119 no 1083 0.309845939520982 1455 144405 SGTC_2617 dihydrotanshinone i 20.83 µM 0.494415995358901 0.313416058982833 no 1084 0.310506209909251 1474 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3246 9135460 32.98 µM 0.494364900666887 0.313433950607592 no 1085 0.310524248819882 1504 41446951 SGTC_3131 9127911 49.47 µM 0.491601565092686 0.31440222981636 no 1086 0.311500518404862 1530 45595681 SGTC_938 3126-1755 342 µM 0.49110838743167 0.314575175031604 no 1087 0.311674894787048 1519 1777771 SGTC_2387 9077560 195.08 µM 0.491065464556888 0.314590228948251 no 1088 0.311690073335998 1442 5303272 SGTC_884 0851-0618 334 µM 0.491024616342153 0.314604555526077 no 1089 0.311704518532948 1554 9642473 SGTC_946 3434-1334 87.4 µM 0.487941308700163 0.31568675965712 no 1090 0.312795706860088 1578 4047976 SGTC_1734 st037168 69.4 µM 0.487730221616772 0.31576090667255 no 1091 0.31287047115007 1488 708907 SGTC_3212 9128307 49.47 µM 0.485968169620423 0.316380138852622 no 1092 0.313494867045102 1412 27243542 SGTC_1013 4112-3890 241 µM 0.48554713741744 0.316528177148212 no 1093 0.313644142088712 1466 705171 SGTC_2195 6536160 144.242 µM 0.485493360920474 0.316547087513069 no 1094 0.313663210498403 1404 3834386 SGTC_3065 9113888 49.47 µM 0.485413768380313 0.316575076902307 no 1095 0.313691433837318 1546 16648368 SGTC_407 eburnamonine 100 µM 0.484945611073153 0.316739729629891 no 1096 0.313857463449652 1458 3195 SGTC_2060 5238662 140 µM 0.48492230586145 0.316747927111654 no 1097 0.313865729509932 1483 790130 SGTC_159 3970-0959 50 µM 0.483718206626512 0.317171584836216 no 1098 0.314292935115312 1570 6615653 SGTC_802 4112-3352 742 µM 0.482963431410207 0.317437271889586 no 1099 0.31456085078164 1600 704594 SGTC_1403 3909-7815 62.9 µM 0.48143540128914 0.317975438929495 no 1100 0.315103540608698 1550 6615483 SGTC_2519 cryptotanshinone 88.04 µM 0.481409404756657 0.317984598150903 no 1101 0.315112776904009 1571 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3113 9123498 49.47 µM 0.481033897403251 0.318116911096197 no 1102 0.315246203619239 1551 8897275 SGTC_2902 5787006 60.46 µM 0.480786573936214 0.31820407013095 no 1103 0.3153340967102 1486 591003 SGTC_3232 9132874 49.47 µM 0.480569935084168 0.318280423900019 no 1104 0.315411093779795 1475 3784940 SGTC_369 0957-0393 4.5 µM 0.480246153548078 0.318394554206977 no 1105 0.315526186093699 1463 6997992 SGTC_1738 st035555 74 µM 0.480134612364621 0.318433875541944 no 1106 0.315565838988154 1516 5331140 SGTC_313 3474-0040 5.03 µM 0.477257880005149 0.319448708402502 no 1107 0.316589250028804 1476 1043375 YIL048W NEO1 SGTC_1215 3852-0577 11.2 µM 0.477143829791428 0.319488970162601 no 1108 0.316629852947824 1621 2884876 SGTC_788 1182-0090 188 µM 0.476909924255073 0.319571549647045 no 1109 0.31671313237012 1671 5715185 SGTC_2248 tofa 1.1 µM 0.476280443772054 0.319793829834059 no 1110 0.316937297914965 1520 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1117 retinoic acid 1.10837 µM 0.47567992501207 0.32000594348408 no 1111 0.317151212493337 1616 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_316 k060-0003 58.6 µM 0.475040284878483 0.320231940213725 no 1112 0.317379129957892 1550 6152314 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.474840128526767 0.320302672872982 no 1113 0.317450464179965 1602 94937 An inhibitor of serotonin biosynthesis. SGTC_1443 4112-3303 14 µM 0.47302636369517 0.320943931248028 no 1114 0.318097185180368 1516 704433 SGTC_2402 5553605 200 µM 0.472947267760385 0.320971907870721 no 1115 0.318125400488798 1601 6758546 SGTC_2772 vinpocetine 57.06 µM 0.472786584110847 0.321028745600724 no 1116 0.318182723229933 1571 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2341 7987486 176.74 µM 0.472169461867703 0.321247075778094 no 1117 0.318402917640974 1650 1258686 SGTC_1028 k015-0029 4.8 µM 0.471618688372266 0.321441984781781 no 1118 0.318599492455328 1501 4588309 SGTC_1051 3253-3903 78 µM 0.470012727705076 0.322010586452484 no 1119 0.31917296213757 1493 5509239 SGTC_216 k038-0035 28.382 µM 0.469016322675176 0.322363580345462 no 1120 0.319528984420471 1505 4444231 YPR107C YTH1 SGTC_969 1313-0238 134 µM 0.468523631775001 0.32253818393081 no 1121 0.319705087730778 1546 5212874 SGTC_832 4083-0019 164 µM 0.468428307540441 0.322571970185947 no 1122 0.319739164322042 1656 1990758 SGTC_2520 obtusaquinone 4.71 µM 0.46741499947858 0.322931212658157 no 1123 0.320101496591741 1619 5967872 SGTC_2681 menadione 3.18 µM 0.466907995832975 0.323111019895875 no 1124 0.320282852187265 1534 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1245 0418-0076 17.2 µM 0.466652167262252 0.323201764383926 no 1125 0.320374378565453 1563 6790114 SGTC_1295 1013-0063 9.78 µM 0.4659889390069 0.323437065858193 no 1126 0.320611708957784 1621 6826038 SGTC_2754 granisetron 64.02 µM 0.464724798962665 0.323885755596927 no 1127 0.321064273446702 1631 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_187 1488-2104 32.728 µM 0.462775395543205 0.324578172166393 no 1128 0.321762684570657 1615 2852859 SGTC_490 phenamil 164 µM 0.459045343280259 0.325904754494854 no 1129 0.323100802466066 1606 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2650 prasterone 100 µM 0.458306580012326 0.326167755886068 no 1130 0.323366098724655 1534 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_511 blebbistatin 171 µM 0.458054707495801 0.326257442845479 no 1131 0.323456568858752 1610 3476986 A myosin inhibitor. SGTC_394 menadione 8.33 µM 0.454127252243306 0.327657231281192 no 1132 0.324868619727613 1551 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1773 st048542 73.5835 µM 0.45305649056971 0.328039284208996 no 1133 0.325254032214262 1467 3237138 SGTC_2793 7325131 81.82 µM 0.452780889591595 0.328137649109119 no 1134 0.325353262957955 1607 4176441 SGTC_2952 9073731 13.78 µM 0.45272306913853 0.328158287352393 no 1135 0.325374082912118 1495 16457353 SGTC_1251 0490-5699 265 µM 0.452630239042251 0.328191422920291 no 1136 0.325407510257549 1660 3883818 SGTC_2903 5923464 63.88 µM 0.449660539962082 0.329252164880983 no 1137 0.326477614129938 1565 2876576 SGTC_410 α-linolenic acid 100 µM 0.449141794918816 0.329437595979213 no 1138 0.326664686073828 1619 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_284 0988-0104 32.6 µM 0.448908712219953 0.329520927605895 no 1139 0.326748755498959 1606 4666532 SGTC_1669 st015249 58.4 µM 0.446488575629881 0.330386673483966 no 1140 0.327622181572492 1616 722793 SGTC_3076 9116187 49.47 µM 0.446138184321915 0.330512092985353 no 1141 0.327748715971338 1670 27241210 SGTC_1283 0922-0125 16.4 µM 0.445850541893723 0.330615066303875 no 1142 0.327852605085261 1659 3360884 SGTC_1634 st006576 41 µM 0.444725774538088 0.331017845613916 no 1143 0.328258970239828 1698 3915356 SGTC_1995 st072814 61.1 µM 0.444046385018822 0.33126122988542 no 1144 0.328504524167205 1504 5769371 SGTC_386 1509-0011 3.07 µM 0.443951318927223 0.33129529201831 no 1145 0.328538890119898 1558 3107280 SGTC_323 4013-0906 34.3 µM 0.442940634111304 0.331657506132083 no 1146 0.328904337638599 1648 2910086 SGTC_2954 9074818 52.69 µM 0.442891602187973 0.331675082437311 no 1147 0.328922070964798 1602 16648742 SGTC_131 0141-0277 33.849 µM 0.442672617479948 0.331753585656775 no 1148 0.3290012756432 1648 1547771 SGTC_3200 9114385 49.47 µM 0.437727647432218 0.333528255781296 no 1149 0.330791862600182 1521 17018030 YLR208W SEC13 SGTC_1197 1601-0112 267 µM 0.437645172643793 0.333557886402583 no 1150 0.330821759937442 1531 7350313 SGTC_347 4534-1311 26.2 µM 0.432468864854347 0.335419643502376 no 1151 0.332700338255676 1552 2862016 SGTC_1096 rimcazole 32.2 µM 0.43220753658557 0.335513742899513 no 1152 0.332795291125026 1571 18528119 A dopamine reuptake inhibitor. SGTC_1652 st011932 78 µM 0.431387341843122 0.335809146597049 no 1153 0.333093376140483 1653 1551076 SGTC_3105 9121040 49.47 µM 0.431132114310439 0.335901090789635 no 1154 0.333186155520814 1524 41448907 SGTC_3272 9137413 49.47 µM 0.430799092550119 0.336021074655668 no 1155 0.333307229725745 1493 17614870 SGTC_2916 7875993 68.79 µM 0.429957340162197 0.336324422727303 no 1156 0.333613336700963 1723 1299250 SGTC_2451 5856223 45.7 µM 0.429459501313439 0.336503882497371 no 1157 0.333794430155737 1535 2179896 SGTC_1070 indatraline 8.81 µM 0.42939017996105 0.336528874249791 no 1158 0.333819649506664 1552 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2829 7992743 58.44 µM 0.42705401187072 0.337371531825588 no 1159 0.334669993952004 1760 16462845 SGTC_2421 5690543 90.72 µM 0.421957217400849 0.339212778065488 no 1160 0.336528122599619 1614 3397993 SGTC_2280 7785178 200 µM 0.421881671379506 0.339240098532496 no 1161 0.336555694453972 1607 2954328 SGTC_248 streptozotocin 5.23457 mM 0.419688625146217 0.34003355976223 no 1162 0.337356467894911 1679 5300 DNA alkylating agent. SGTC_2216 7189485 200 µM 0.419673715357665 0.340038956670566 no 1163 0.337361914613162 1667 731273 SGTC_3286 9117135 37.221 µM 0.419644367249617 0.340049579924956 no 1164 0.33737263591613 1533 3438150 SGTC_17 0960-0276 49.807 µM 0.418634406753654 0.340415236775481 no 1165 0.337741670002608 1602 6821114 SGTC_2207 7258803 200 µM 0.417656491031634 0.34076943481828 no 1166 0.338099143818868 1651 3666799 SGTC_214 4373-3496 70 µM 0.417214048747103 0.340929732202309 no 1167 0.338260925112417 1666 3779166 SGTC_1035 k081-0041 55.2 µM 0.416670468300529 0.341126711385184 no 1168 0.338459728979177 1684 731709 SGTC_1926 methyl fluorone black 53.6 µM 0.415343245189578 0.341607843814754 no 1169 0.338945323863876 1509 72721 Reacts with homocysteine. SGTC_3308 9128332 17.569 µM 0.415225064509276 0.341650698057349 no 1170 0.33898857595769 1724 17332805 YDL196W YDL196W SGTC_244 nsc-207895 1.295 µM 0.413710273533987 0.342200166551656 no 1171 0.339543151150108 1534 42640 SGTC_423 5-fluorouracil 457 µM 0.413460455418369 0.342290816596258 no 1172 0.339634644670404 1507 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2729 fluphenazine 10.66 µM 0.413374178895802 0.342322125366982 no 1173 0.339666244825988 1540 3372 An atypical antipsychotic. SGTC_3203 9113543 49.47 µM 0.411612652390105 0.342961600020092 no 1174 0.340311678204235 1669 17018012 SGTC_2262 9014885 67.46 µM 0.411560895402015 0.342980395813035 no 1175 0.340330649348258 1703 6457424 SGTC_2462 5162487 171.77 µM 0.411052642989674 0.343164990696909 no 1176 0.340516967001004 1647 2259986 SGTC_838 0109-0203 71.4 µM 0.409912126399439 0.343579357138234 no 1177 0.340935204778188 1601 759422 SGTC_560 2332-1943 155 µM 0.409240465301674 0.3438234694965 no 1178 0.341181600526085 1616 21177716 SGTC_3137 9097352 49.47 µM 0.408405668993675 0.344126963416744 no 1179 0.341487936068514 1696 44120435 SGTC_1997 st073024 93.8 µM 0.407308934690434 0.344525838683677 no 1180 0.341890550703432 1664 686268 SGTC_3329 9141233 27.5565 µM 0.406787068826079 0.344715698721891 no 1181 0.342082192504372 1694 4909101 YNL103W MET4 SGTC_2812 7970281 58.44 µM 0.406466048044313 0.344832508739103 no 1182 0.342200099335506 1729 2233435 SGTC_1757 st041620 31.8375 µM 0.406286622908742 0.344897802711818 no 1183 0.342266006598749 1594 5289815 SGTC_2818 7996756 12.99 µM 0.406023302759751 0.344993634988652 no 1184 0.342362739262119 1587 2241621 SGTC_2161 5662504 8.5105 µM 0.405575618504407 0.345156587238347 no 1185 0.342527223221724 1593 2859334 SGTC_3033 9090887 49.47 µM 0.405274245175213 0.345266300059335 no 1186 0.342637967812779 1553 19325384 SGTC_3269 9137823 49.47 µM 0.403399584839719 0.345949048572524 no 1187 0.34332714605978 1586 17682936 SGTC_486 niguldipine 82 µM 0.403189013820633 0.346025769573821 no 1188 0.343404590540231 1641 1236 A calcium channel blocker. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.40317965659681 0.346029179000611 no 1189 0.343408032122437 1677 676296 Flavone; oxidizing agent. SGTC_1885 st057546 99.9 µM 0.403014539892083 0.346089343483099 no 1190 0.34346876409898 1703 702008 SGTC_1327 1436-0082 2.18 µM 0.402949421579378 0.346113072069451 no 1191 0.343492716535184 1628 15992205 SGTC_1177 0983-0204 23.6 µM 0.402265797530121 0.346362215593514 no 1192 0.343744211542514 1765 766818 SGTC_2586 curcumin 80 µM 0.401480791130245 0.346648389443549 no 1193 0.344033088904013 1717 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_686 1319-0111 510 µM 0.401299915646366 0.346714339960892 no 1194 0.344099662844561 1730 4562600 SGTC_2714 st079313 56.9 µM 0.401048366471242 0.346806067124007 no 1195 0.344192257332707 1614 2939799 SGTC_1875 nocodazole 6 µM 0.400455677169641 0.347022226200904 no 1196 0.344410461393003 1693 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_234 nsc-17383 10.7 µM 0.39963277076111 0.347322430053382 no 1197 0.344713507883236 1711 408974 SGTC_1334 1486-0610 236 µM 0.398767326064893 0.347638255634169 no 1198 0.345032327212289 1657 3742339 SGTC_807 1315-0151 48 µM 0.397919430350258 0.347947779674678 no 1199 0.345344788433177 1761 4011080 SGTC_630 4356-0227 183 µM 0.397594010653112 0.348066600947222 no 1200 0.345464738072668 1639 779312 SGTC_2884 9058502 51.95 µM 0.397489106476275 0.348104908040551 no 1201 0.34550340904126 1583 6471554 SGTC_168 3970-0862 530.542 µM 0.397237150487817 0.348196919302888 no 1202 0.345596294504857 1646 3135186 SGTC_1292 0kpi-0043 232 µM 0.397010878336685 0.348279558756628 no 1203 0.345679719353215 1618 3333905 SGTC_664 1222-0054 14.9 µM 0.396865642801242 0.348332605692315 no 1204 0.345733270557285 1630 6813991 SGTC_2644 guaiazulene 100 µM 0.395811022771267 0.348717892097514 no 1205 0.346122222272533 1700 3515 A coloring agent. SGTC_2526 patulin 37.61 µM 0.393751616025063 0.349470708874409 no 1206 0.346882214651517 1679 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2661 dactinomycin 12.96 µM 0.391048571681804 0.350459706425176 no 1207 0.347880666815422 1650 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3202 9113761 49.47 µM 0.390919218992598 0.3505070598461 no 1208 0.347928473714515 1782 4798415 SGTC_672 1441-0018 53.7 µM 0.390798169910368 0.350551375587696 no 1209 0.347973213909237 1601 251141 SGTC_1525 8-methoxypsoralen 92.5 µM 0.389861368659661 0.350894404733189 no 1210 0.348319530693892 1814 4114 Related to psoralen; DNA damaging agent. SGTC_1133 3473-0247 50 µM 0.386975037642061 0.351952057736679 no 1211 0.349387344058751 1571 711311 SGTC_2012 4023501 200 µM 0.386678045042619 0.352060951442778 no 1212 0.349497285876677 1603 3477460 SGTC_1086 cerivastatin 2.18 µM 0.385750816452328 0.35240100211707 no 1213 0.349840611992236 1694 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_916 4466-0038 42 nM 0.382495134631723 0.353595919950649 no 1214 0.351047068530647 1738 5722064 YGL116W CDC20 SGTC_694 1315-0438 43.2 µM 0.382304294610094 0.353666007999525 no 1215 0.351117834780398 1704 6793154 SGTC_2928 9011484 9.79 µM 0.3819684027676 0.353789379936939 no 1216 0.351242400890411 1647 2994751 SGTC_235 0330-0087 5 mM 0.381720293684282 0.353880519425439 no 1217 0.351334422865944 1647 46494818 YHR062C RPP1 SGTC_2439 5492030 7.2 µM 0.381543430065627 0.353945492976582 no 1218 0.351400025703221 1749 5722370 SGTC_3270 9137563 49.47 µM 0.379827298335921 0.354576160790124 no 1219 0.352036808571457 1707 17015724 SGTC_2095 5432005 200 µM 0.379228241411551 0.35479640452004 no 1220 0.35225919074759 1636 783734 SGTC_650 1328-0195 38 µM 0.377233009212891 0.355530302849064 no 1221 0.353000225730471 1752 2780821 SGTC_963 1269-2853 151 µM 0.376997859926425 0.355616832233505 no 1222 0.353087597656041 1596 3668223 SGTC_1934 st074720 32.6 µM 0.375564999273472 0.356144251787618 no 1223 0.353620157736221 1593 17250992 SGTC_3157 9099274 49.47 µM 0.375484032530891 0.356174062944606 no 1224 0.353650259706292 1781 17217662 SGTC_1779 st039427 55 µM 0.373648014036776 0.356850302546434 no 1225 0.35433310350686 1835 1124498 SGTC_2658 polymyxin b sulfate 77.05 µM 0.372819924162203 0.357155450789478 no 1226 0.354641236454192 1664 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2584 androsterone 48.74 µM 0.372451771916652 0.357291142971429 no 1227 0.354778256781271 1690 2754130 A steroid. SGTC_1896 st058441 89 µM 0.370262613410306 0.358098387065297 no 1228 0.355593413768998 1628 688759 SGTC_1847 st056231 15 µM 0.370043227436465 0.358179319886012 no 1229 0.35567514101944 1622 5393180 SGTC_2747 doxorubicin 7.63 µM 0.3688665201565 0.35861352304132 no 1230 0.356113609680743 1742 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3107 9121808 49.47 µM 0.368259757760341 0.358837488897833 no 1231 0.356339777963162 1769 662681 SGTC_3279 9140807 49.47 µM 0.367858163411856 0.358985750596436 no 1232 0.356489498468393 1668 45595718 SGTC_1696 st025591 34.7925 µM 0.366848009924996 0.359358775701316 no 1233 0.356866196862017 1660 2787147 SGTC_1679 SEC14.276 6.7 µM 0.366807824683622 0.359373617908642 no 1234 0.356881185312016 1829 1005053 YMR079W SEC14 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.365949184228144 0.35969080291124 no 1235 0.357201497179979 1659 442882 SGTC_1751 st044839 27.194 µM 0.365338529469676 0.359916439905596 no 1236 0.357429360390341 1714 5291326 SGTC_1614 st002383 48.6 µM 0.36507036694989 0.360015541416302 no 1237 0.357529440156892 1683 1947235 SGTC_271 rotenone 740 µM 0.36427411012314 0.360309859646579 no 1238 0.357826665417215 1745 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1027 k015-0025 8.67 µM 0.364121925278811 0.360366120744101 no 1239 0.357883482511208 1630 3598955 SGTC_2716 st080858 38.6235 µM 0.363122674288592 0.360735608125255 no 1240 0.358256623685276 1756 5296050 SGTC_2515 chrysin 20.77 µM 0.359191092092448 0.362190626430642 no 1241 0.359726070037797 1760 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2219 9098279 200 µM 0.359135192767938 0.362211328335922 no 1242 0.359746977678613 1791 902349 SGTC_1277 0873-0036 22 µM 0.359041516198759 0.362246021670576 no 1243 0.359782015824103 1784 5965735 SGTC_1142 3253-1408 9.78 µM 0.357906574546164 0.36266643977196 no 1244 0.360206615217494 1782 256655 SGTC_2776 terbinafine 19.92 µM 0.35743723980824 0.362840344564674 no 1245 0.360382251117628 1686 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3142 9086498 49.47 µM 0.357397366350935 0.362855120367455 no 1246 0.360397174044917 1814 25236367 SGTC_3216 9129716 49.47 µM 0.356908296788789 0.363036370201458 no 1247 0.360580229129974 1612 8056934 SGTC_1000 4048-0884 8.67 µM 0.356170281791973 0.363309937617671 no 1248 0.360856523114418 1724 13040088 SGTC_822 1487-0950 154 µM 0.355830120643148 0.363436052047528 no 1249 0.360983895232192 1804 1958375 SGTC_3225 9130819 49.47 µM 0.355719265366841 0.363477154736963 no 1250 0.36102540792303 1737 4547121 SGTC_699 0375-0592 111 µM 0.355688986428117 0.36348838177236 no 1251 0.361036746957301 1791 762578 SGTC_1727 st034309 9.9045 µM 0.354583887788818 0.363898218087196 no 1252 0.361450674257139 1818 870305 SGTC_3182 9108849 49.47 µM 0.353242661835897 0.364395833642527 no 1253 0.361953263621232 1728 17133045 SGTC_2737 bleomycin 30.5 nM 0.353108612969451 0.364445580424639 no 1254 0.362003508034356 1700 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.351683534765517 0.364974581221514 no 1255 0.362537805036105 1716 97141 SGTC_1152 3909-8331 15.9 µM 0.351614404010733 0.365000249675208 no 1256 0.362563730682212 1693 16001939 SGTC_1615 st002656 86.5 µM 0.351588352559361 0.365009922813099 no 1257 0.362573500747844 1675 1584458 SGTC_2088 5278280 127.392 µM 0.34991671883206 0.365630794795218 no 1258 0.363200599734149 1714 791502 SGTC_444 curcumin 90.4 µM 0.349655442218161 0.365727869049842 no 1259 0.363298648599724 1738 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1624 st003710 6.25 µM 0.348895835955188 0.366010140647623 no 1260 0.363583755709561 1809 24207033 SGTC_1518 st038567 90.8 µM 0.348375628372685 0.366203492952551 no 1261 0.363779051630016 1697 77966 SGTC_2962 9082311 13.18 µM 0.346652476690914 0.36684420153143 no 1262 0.364426208430924 1638 16459453 SGTC_151 3013-0144 2.285 µM 0.346646669986927 0.366846361229806 no 1263 0.364428389884894 1802 906558 YHR107C CDC12 SGTC_635 k038-0028 24.7 µM 0.346260132650458 0.366990136266475 no 1264 0.364573613531786 1755 4035102 SGTC_1059 3448-6867 171 µM 0.345821879386158 0.367153169941754 no 1265 0.364738290575178 1850 3934407 SGTC_1400 3771-8998 51.5 µM 0.345617541625956 0.367229193393071 no 1266 0.364815080597814 1766 670767 SGTC_1354 1498-1681 81 µM 0.344931402147927 0.36748450827133 no 1267 0.365072971116027 1729 5754243 SGTC_1202 1988-0068 29.6 µM 0.344381090157997 0.367689323614908 no 1268 0.365279854001706 1626 2850480 SGTC_1842 st055362 61.2 µM 0.342494014741152 0.36839194158836 no 1269 0.365989573749577 1771 676032 SGTC_2460 5552655 174.22 µM 0.342467960585646 0.368401645463026 no 1270 0.365999375805279 1665 5401989 SGTC_2094 5332512 191.667 µM 0.341762330622749 0.368664489365843 no 1271 0.366264880103648 1804 755774 SGTC_297 0986-0032 24 µM 0.340598002797382 0.369098330416871 no 1272 0.366703116590662 1705 2847425 SGTC_644 1498-1197 63.3 µM 0.336116596948634 0.370769702493956 no 1273 0.368391471616361 1777 6741615 SGTC_2229 7354935 190 µM 0.334723056441378 0.371289932441225 no 1274 0.368917003614931 1779 318112 SGTC_1415 3966-0071 78.1 µM 0.333509556814178 0.371743142044646 no 1275 0.369374838349328 1752 2893185 SGTC_2206 7254556 146.969 µM 0.33323415391829 0.371846022426953 no 1276 0.369478769448171 1804 4398905 SGTC_1360 1598-0022 39.8 µM 0.330762093494139 0.372769902144468 no 1277 0.370412097851063 1818 761525 SGTC_1161 k007-0610 110 µM 0.330612781938712 0.372825727650901 no 1278 0.370468495048935 1781 5843850 SGTC_2163 5671233 125 µM 0.330397044286852 0.372906393665082 no 1279 0.370549987289755 1833 701023 SGTC_2177 5811945 192 µM 0.330327574626375 0.372932370106896 no 1280 0.370576229834952 1812 5343475 SGTC_582 0987-0078 156 µM 0.330048902257599 0.373036578474633 no 1281 0.370681505902423 1765 1625765 SGTC_1854 st056233 32.9 µM 0.32973421540588 0.373154265475725 no 1282 0.370800399061347 1862 5393174 SGTC_670 4204-0025 119 µM 0.329513253720761 0.373236908090013 no 1283 0.3708838888955 1810 719039 SGTC_309 k408-0051 1.48 µM 0.329369501453525 0.373290676484797 no 1284 0.370938208603464 1741 3640463 SGTC_1315 1237-0019 3.69 µM 0.328004081670119 0.373801514307658 no 1285 0.37145428824003 1811 825140 SGTC_264 promethazine 12.5 mM 0.3279983162602 0.37380367176305 no 1286 0.371456467848652 1828 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1919 st067113 52.3 µM 0.326675509991056 0.374298779218528 no 1287 0.371956662534706 1705 1268243 SGTC_1056 3448-1962 115 µM 0.3256505518083 0.374682549039227 no 1288 0.3723443801813 1763 715507 SGTC_2800 7887935 81.82 µM 0.324650620004623 0.375057068011882 no 1289 0.372722755669697 1778 2961002 SGTC_207 4185-0010 4.486 µM 0.323700765799711 0.375412939835657 no 1290 0.373082295511824 1831 3761753 SGTC_1178 0988-0033 191 µM 0.323467432562207 0.37550037656717 no 1291 0.373170633988825 1772 5392207 SGTC_1991 st073000 8.92 µM 0.323030162051195 0.375664251729478 no 1292 0.373336199770648 1814 4301969 YIL048W NEO1 SGTC_577 r071-0003 38.6 µM 0.321532020059576 0.376225877904071 no 1293 0.373903625449959 1701 4568517 YMR134W ERG29 SGTC_598 3937-0236 20.2 µM 0.320222717982885 0.376716926191125 no 1294 0.374399751371256 1805 1379313 SGTC_2891 9063876 19.48 µM 0.319961281034162 0.376815000952377 no 1295 0.374498841037587 1908 6472478 SGTC_1402 3909-7673 35.9 µM 0.318742356740373 0.377272369813432 no 1296 0.374960946270246 1723 5328014 SGTC_967 1306-0166 352 µM 0.318557759700183 0.377341649963982 no 1297 0.37503094435101 1879 4437607 SGTC_2014 4013930 200 µM 0.31718433549757 0.37785722643297 no 1298 0.375551867598451 1861 64556 SGTC_1388 3346-4487 254 µM 0.314715434388135 0.378784586131202 no 1299 0.37648886218888 1804 3345614 SGTC_1617 st002906 78 µM 0.313910600157651 0.379087046238394 no 1300 0.376794469639534 1740 5150859 SGTC_2309 7664088 163.95 µM 0.311972506333607 0.379815693597998 no 1301 0.377530709027945 1914 704922 SGTC_2347 9049783 174.81 µM 0.310660633476788 0.380309148861335 no 1302 0.378029313657215 1835 6467988 YPL169C MEX67 SGTC_175 3793-3120 23.7 µM 0.31040708763375 0.380404541520221 no 1303 0.378125702501542 1744 5322297 SGTC_2940 9060638 45.86 µM 0.309861635134611 0.380609784142127 no 1304 0.378333089274524 1772 4027022 SGTC_58 0957-0393 9 µM 0.308496355655234 0.38112365811611 no 1305 0.378852336440288 1750 6997992 SGTC_1372 2752-0194 270 µM 0.308140900367769 0.381257481444142 no 1306 0.378987560180505 1725 823334 SGTC_501 nsc-95397 161 µM 0.30789143642599 0.381351409177634 no 1307 0.379082471109975 1858 262093 SGTC_2279 7948423 32.93 µM 0.307072315871589 0.381659872160078 no 1308 0.379394164555841 1934 1247112 SGTC_825 1988-2224 89.6 µM 0.305779607190755 0.382146830979452 no 1309 0.379886228175949 1770 1180859 SGTC_3171 9103192 49.47 µM 0.305718443756263 0.382169875656716 no 1310 0.379909514582226 1879 13018434 SGTC_425 3825-7017 13.1 µM 0.304260648968439 0.382719255462654 no 1311 0.380464661185195 1835 3397440 SGTC_2839 9003951 25.97 µM 0.303421535497207 0.383035588161502 no 1312 0.380784317907958 1862 2990634 SGTC_2830 7992007 71.43 µM 0.302422070127982 0.383412472821706 no 1313 0.381165166204841 1702 1952075 SGTC_984 1492-0255 2.91 µM 0.301766159561756 0.383659867681674 no 1314 0.381415164843147 1796 1585198 SGTC_29 0299-0004 12.984 µM 0.301285974982122 0.383841012691666 no 1315 0.381598217351821 1832 16871 A napthoquinone isolated from Swertia calycina. SGTC_2240 6690706 185.951 µM 0.298769729967273 0.384790656076268 no 1316 0.382557874291764 1686 805876 SGTC_692 k241-0027 77.8 µM 0.295925573514283 0.385864887362184 no 1317 0.383643460221433 1875 3600480 SGTC_874 0599-0792 117 µM 0.295503218711867 0.386024484675908 no 1318 0.383804746946611 1940 765305 SGTC_766 1391-0721 126 µM 0.294490593666388 0.386407208871556 no 1319 0.384191525042724 1887 1020919 YIL115C NUP159 SGTC_2713 st079149 53.4 µM 0.294031797450789 0.386580648469782 no 1320 0.384366802952459 1804 3103253 SGTC_1466 k213-0079 57.5 µM 0.293187029632029 0.386900056887759 no 1321 0.384689598781352 1789 3657981 SGTC_562 3772-2733 112 µM 0.291417312152163 0.387569438773612 no 1322 0.385366087833788 1890 2876874 YIL048W NEO1 SGTC_117 lucigenin 22.078 µM 0.29058141458079 0.387885726914808 no 1323 0.385685738013269 1697 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3160 9100216 49.47 µM 0.290460766929724 0.387931383897558 no 1324 0.385731880518014 1884 17191039 SGTC_1850 st056238 17 µM 0.289302959465372 0.388369614467619 no 1325 0.386174773890525 1800 5393177 SGTC_2635 hydroquinidine 100 µM 0.285869482720534 0.389670020545138 no 1326 0.387489044017444 1787 442912 An experimental heart treatment. SGTC_77 0828-0286 12.516 µM 0.285287576622115 0.389890536444693 no 1327 0.387711914988155 1884 745345 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.28507893409256 0.389969611093975 no 1328 0.38779183442783 1877 688751 SGTC_289 k017-0060 526 µM 0.28477832888218 0.390083547221993 no 1329 0.387906988053383 1805 5512909 SGTC_510 ag-490 170 µM 0.283244418684418 0.390665080486033 no 1330 0.388494740344447 1908 5328779 SGTC_266 formosanin C 406 nM 0.283213024260624 0.390676985242383 no 1331 0.388506772497689 1871 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2549 cedrol 20.94 µM 0.283149458414578 0.390701089706454 no 1332 0.388531134922369 1893 6708665 A sedative which affects the nervous system. SGTC_2964 9083345 53.42 µM 0.282966886103267 0.390770324310218 no 1333 0.388601110537212 1743 17741579 SGTC_2870 9038528 12.99 µM 0.28196960782707 0.391148570684415 no 1334 0.388983407278976 1803 6463316 SGTC_737 1950-0117 57.9 µM 0.281796623618023 0.391214190394616 no 1335 0.389049730012909 1931 5393513 SGTC_2551 apiole 73.87 µM 0.279647059656806 0.392029862262547 no 1336 0.389874149267866 1862 10659 A possible DNA adduct former. SGTC_971 1315-0384 26.7 µM 0.279044099298554 0.392258746542537 no 1337 0.390105490989103 1750 6769120 SGTC_2968 9090663 33.37 µM 0.278889454708666 0.392317455774243 no 1338 0.39016483075977 1817 25236811 SGTC_595 3909-8003 73.7 µM 0.27865842876713 0.392405166967887 no 1339 0.390253484126953 1853 699517 SGTC_2989 9073649 71.4286 µM 0.278555424486742 0.392444275283621 no 1340 0.39029301259416 1966 21367202 SGTC_2192 5915882 198.485 µM 0.278550066564169 0.39244630959121 no 1341 0.390295068757873 1831 2876149 SGTC_1279 0874-0590 65.2 µM 0.275668102445389 0.393540964504617 no 1342 0.391401498598947 1857 3523074 SGTC_2982 9019404 25.97 µM 0.275619471430124 0.393559443245205 no 1343 0.391420176353499 1604 22333232 SGTC_1190 1486-1332 13 µM 0.274885772555097 0.393838262118311 no 1344 0.391701999049479 1812 4150046 SGTC_181 1447-1644 8.07 µM 0.274565471145569 0.393959999536593 no 1345 0.391825048564615 1938 534600 SGTC_2796 7949634 45.45 µM 0.274278136891469 0.394069215898427 no 1346 0.391935442366163 1771 2971588 SGTC_1966 st070145 16.1 µM 0.274231080299328 0.394087103003415 no 1347 0.391953522335103 1773 3748532 SGTC_1530 rhein 70.4 µM 0.273701764872405 0.394288321238387 no 1348 0.392156910679878 1871 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1140 3229-1848 2.98 µM 0.272756295175024 0.394647809892332 no 1349 0.392520278725058 1939 2849525 SGTC_1641 st009299 47.1 µM 0.271470226371276 0.395136945906831 no 1350 0.393014698051036 1885 4046054 SGTC_3208 9114115 49.47 µM 0.2706766886617 0.395438837985515 no 1351 0.393319853737786 1691 650895 SGTC_955 1216-0110 33 µM 0.268418371027005 0.396298331208893 no 1352 0.394188650080807 1772 3619719 SGTC_2376 9072922 81.32 µM 0.268407355887528 0.396302524700537 no 1353 0.39419288900444 1873 17087968 SGTC_355 1311-2252 105 µM 0.266947939467582 0.396858234166307 no 1354 0.39475462256464 1776 5338538 SGTC_1907 st060210 83.7 µM 0.266747684897938 0.396934502496682 no 1355 0.394831718225005 1929 688793 SGTC_94 0334-0113 514.748 µM 0.265885761843688 0.39726281678669 no 1356 0.395163595465147 1737 6795178 SGTC_2427 5545055 42.75 µM 0.264816226388281 0.397670313724896 no 1357 0.395575518089527 1846 5372858 SGTC_1613 st002381 52.1 µM 0.262837489859607 0.398424513756654 no 1358 0.396337919202868 1971 551167 SGTC_684 1140-0066 328 µM 0.262309267473436 0.398625911251853 no 1359 0.39654150885265 1826 6813534 SGTC_3072 9116419 49.47 µM 0.262036379126186 0.398729967081222 no 1360 0.39664669765955 1803 17170162 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.261524922355474 0.398925011497428 no 1361 0.396843866411152 1844 2346 DNA damaging agent; causes G2/M arrest. SGTC_1045 1348-1485 165 µM 0.260203351056974 0.399429110449467 no 1362 0.397353459751285 1903 6810614 SGTC_1052 3253-3998 198 µM 0.255638928225315 0.401171444717004 no 1363 0.399114828265868 1878 5450317 SGTC_882 0843-0131 351 µM 0.254989784287433 0.401419396921852 no 1364 0.399365494727254 1994 5425421 SGTC_2241 6772625 37.8075 µM 0.254905442947491 0.401451615530185 no 1365 0.399398066122581 1945 2285411 SGTC_3355 9151058 44.0485 µM 0.254081220424532 0.401766505883376 no 1366 0.399716405665436 1943 17015728 SGTC_893 0958-0369 48.9 µM 0.252646930573115 0.402314621571123 no 1367 0.400270530413187 2001 6819948 SGTC_335 4077-0256 27.6 µM 0.252391563984525 0.402412230416272 no 1368 0.400369210048327 1929 3121989 SGTC_2384 9036245 200 µM 0.25231270853748 0.402442372586479 no 1369 0.400399682926821 1947 6462766 SGTC_2525 harmine 47.85 µM 0.250949999764083 0.402963353881867 no 1370 0.400926383370101 1922 5280953 A monoamine oxidase inhibitor SGTC_3084 9116877 49.47 µM 0.250663682911948 0.403072838477528 no 1371 0.401037070602724 1982 27241325 SGTC_868 0527-0199 213 µM 0.249345580489824 0.403576965071746 no 1372 0.401546738159288 1874 2849450 SGTC_992 3909-8734 162 µM 0.248842663148991 0.403769355080678 no 1373 0.401741244223376 1821 4288319 SGTC_2385 9074692 200 µM 0.247525573777216 0.404273315176676 no 1374 0.402250751064751 1836 17046906 SGTC_3087 9117406 49.47 µM 0.247439113045952 0.404306403356664 no 1375 0.402284203615806 1861 42546093 SGTC_2725 haloperidol 53.21 µM 0.247248491104363 0.404379356037918 no 1376 0.40235795974432 1917 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_163 TUB2.036 7.546 µM 0.24545840405048 0.405064599866169 no 1377 0.403050755937168 1984 15992207 YJR013W GPI14 SGTC_628 1636-0253 16 µM 0.242279488101731 0.406282202658169 no 1378 0.404281803250572 1980 4456143 SGTC_1434 4073-0095 163 µM 0.241451420526798 0.406599522212372 no 1379 0.404602631763966 1971 24133745 SGTC_2452 5863136 48.41 µM 0.240801727177709 0.406848530843544 no 1380 0.404854395456331 1861 2184096 SGTC_3023 9089636 49.47 µM 0.240681027094617 0.406894795838738 no 1381 0.404901172477301 2031 17249241 SGTC_3040 9091894 49.47 µM 0.240155231072973 0.40709635145037 no 1382 0.405104959280197 1958 25236966 SGTC_1270 0831-1170 17.3 µM 0.239892071138932 0.407197238902869 no 1383 0.405206963863754 1903 6764716 SGTC_2189 6047310 154.431 µM 0.238598223419538 0.407693349892556 no 1384 0.405708571426699 1878 711535 SGTC_148 3253-0744 288.01 µM 0.238549470175982 0.407712046661302 no 1385 0.405727475444022 1935 6893655 SGTC_380 3970-0968 6 µM 0.236173064508155 0.408623647390686 no 1386 0.406649189886858 1862 2891601 SGTC_110 0850-0284 111.64 µM 0.235935306538008 0.408714879799583 no 1387 0.406741435423588 1993 3906265 SGTC_2294 7971431 200 µM 0.235798572870208 0.408767349437679 no 1388 0.406794487810757 1952 5741572 SGTC_2825 7998094 58.44 µM 0.23354388301644 0.40963279033679 no 1389 0.40766954888178 1890 2987815 SGTC_2005 4024620 188 µM 0.231332018756671 0.410482221142687 no 1390 0.408528436915717 1900 236743 SGTC_96 0929-0093 37.281 µM 0.231234368593425 0.410519731824951 no 1391 0.408566365568542 1858 6991579 SGTC_2335 9018011 154.17 µM 0.230882496421015 0.410654904440203 no 1392 0.408703044611529 1999 6458208 SGTC_46 0329-0187a 2.197 µM 0.230727280828831 0.410714534289949 no 1393 0.40876333912337 1936 46494817 SGTC_2396 5342950 42.78 µM 0.230567769706952 0.410775816522152 no 1394 0.408825304511598 1879 1886677 SGTC_793 0488-0545 106 µM 0.230104276818403 0.410953897204327 no 1395 0.409005370819172 1855 292548 SGTC_566 0958-0068 16.5 µM 0.229144686117382 0.41132264414776 no 1396 0.409378231399187 1956 6815365 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.228822315807544 0.411446540673826 no 1397 0.409503510700617 1960 368090 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.226163337078066 0.412468801247225 no 1398 0.410537192309812 1939 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1019 4262-0212 3.4 µM 0.222781775589302 0.413769720522567 no 1399 0.411852676274378 2043 4677213 SGTC_2247 cerulenin 830 nM 0.222728583612204 0.413790191590722 no 1400 0.411873376800371 1994 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_567 1080-0542 68.4 µM 0.221810262279493 0.414143646791079 no 1401 0.412230795152433 2020 5950415 SGTC_2592 piperlongumine 83.33 µM 0.217252746939347 0.41589882501198 no 1402 0.41400569002734 1860 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2505 galangin 7.89 µM 0.216311045558848 0.416261700995135 no 1403 0.414372649882208 1847 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_958 1222-0007 33 µM 0.215838915032798 0.416443659047176 no 1404 0.414556656688011 1975 7312461 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.21400179207573 0.417151852196126 no 1405 0.415272829839977 1888 279621 SGTC_282 k297-0036 65.7 µM 0.212979345221504 0.417546112195263 no 1406 0.415671536605831 1985 5061378 SGTC_2282 7944268 200 µM 0.211358036544266 0.418171465756219 no 1407 0.416303949511814 1994 2970414 SGTC_71 0417-1750 47.813 µM 0.210346494244996 0.41856173178238 no 1408 0.416698624874845 2070 6811472 SGTC_1020 4335-0961 93.3 µM 0.210026598939226 0.418685168209431 no 1409 0.416823456526564 1844 669075 SGTC_2965 9082772 38.63 µM 0.209828606111256 0.418761570739533 no 1410 0.41690072279388 2055 16459634 SGTC_2785 7756463 72.73 µM 0.209213975989754 0.418998767003125 no 1411 0.417140601288918 1904 2201551 SGTC_3243 9134147 49.47 µM 0.207384070534809 0.419705132793719 no 1412 0.417854961028436 2058 24282180 SGTC_2083 5306046 65.942 µM 0.206447806944128 0.420066642163467 no 1413 0.418220565247561 1926 539837 SGTC_914 3820-6779 408 µM 0.205779871281732 0.42032458620521 no 1414 0.418481432547005 1933 2893481 SGTC_255 tunicamycin 200.472 nM 0.204554945832381 0.420797717953135 no 1415 0.418959929497392 2064 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_204 PMA1.184 62.41 µM 0.203894692641667 0.421052790567701 no 1416 0.41921789631036 1981 2252213 YGL008C PMA1 SGTC_3042 9091578 49.47 µM 0.20267187566985 0.421525283343404 no 1417 0.419695753456153 2042 25236497 SGTC_1205 4161-2785 76 µM 0.20263708398782 0.421538728400683 no 1418 0.419709351220374 1836 3498106 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.200776393228398 0.422257915153048 no 1419 0.420436711262081 1906 6708561 SGTC_2380 9035439 200 µM 0.200522844067878 0.422355936087275 no 1420 0.420535846906781 2015 6462575 SGTC_1132 3456-3614 2.5 µM 0.2001286764675 0.422508329007652 no 1421 0.420689973216002 2095 3125502 SGTC_7 0192-1582 4.227 µM 0.199796283457837 0.42263684767674 no 1422 0.420819954048667 1979 252616 SGTC_84 0443-0269 128.823 µM 0.199457287539195 0.422767927821476 no 1423 0.420952525811269 2047 6150058 SGTC_482 fipronil 114 µM 0.19889797157424 0.422984218192206 no 1424 0.421171278132423 2063 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3351 9150312 21.596 µM 0.19864675837627 0.423081371191937 no 1425 0.421269537266156 2062 4904905 SGTC_2038 4100038 30.985 µM 0.197832765258888 0.423396203131609 no 1426 0.421587954904534 1974 3596803 SGTC_3104 9120930 49.47 µM 0.1971188420041 0.423672370853142 no 1427 0.42186726945566 1978 17014836 SGTC_3073 9114972 49.47 µM 0.196471287289611 0.423922897592188 no 1428 0.422120652053892 2084 41905075 SGTC_262 fenpropimorph 62.5 µM 0.194578283563344 0.424655441102495 no 1429 0.422861552652958 1998 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_585 0kpi-0023 191 µM 0.194029077154767 0.424868018613107 no 1430 0.423076557126988 2054 64601 SGTC_563 tetrahydrosecaminediol 614 µM 0.193016874640973 0.425259862013489 no 1431 0.423472876267425 2069 334274 A psychoactive constituent of the cannabis plant. SGTC_1691 st019933 84.6 µM 0.192011719577506 0.425649050283759 no 1432 0.423866512670961 2097 6176082 SGTC_1374 2889-5571 141 µM 0.19159636086452 0.425809895142425 no 1433 0.424029196656578 1939 2853281 SGTC_2456 5770359 74.46 µM 0.191377709148574 0.425894571505442 no 1434 0.424114841408411 2050 3118787 SGTC_509 pifithrin 175 µM 0.190741083050859 0.426141134557193 no 1435 0.424364224968589 2062 4817 A p53 inhibitor. SGTC_353 1988-1175 58.3 µM 0.190721567726944 0.426148693230225 no 1436 0.424371870124601 1903 2788357 SGTC_1938 st074717 56.4 µM 0.188949544111525 0.426835145953763 no 1437 0.425066181154221 1982 17250979 SGTC_1937 st074714 47.2 µM 0.188774458822702 0.426902983172767 no 1438 0.425134795405495 1837 17250970 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.188048178406825 0.427184405341153 no 1439 0.425419441951494 1995 521171 SGTC_540 1187-0821 17.3 µM 0.188016339887092 0.427196743112719 no 1440 0.42543192111421 1883 847520 SGTC_1737 st035557 69.7 µM 0.187561315595193 0.427373077734543 no 1441 0.425610276827043 1922 5716916 SGTC_996 3970-0799 1.8 µM 0.186766174593208 0.427681251893913 no 1442 0.425921984488966 2072 6615648 YGL040C HEM2 SGTC_2069 5228469 200 µM 0.186735392610403 0.427693183008062 no 1443 0.425934052437831 1971 2835210 SGTC_3 0833-0587 95.581 µM 0.186603780384981 0.427744196727541 no 1444 0.425985651247911 2004 5382644 SGTC_2491 paeonol 100 µM 0.184050157481427 0.428734234964472 no 1445 0.426987053489203 1950 11092 Increases levels of cortical cytochrome oxidase. SGTC_2152 5568786 200 µM 0.183100980557061 0.429102345047778 no 1446 0.427359393204013 2030 5399883 SGTC_1073 triclabendazole 3.09 µM 0.182084955412771 0.429496448558172 no 1447 0.427758027603724 1986 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1755 st041960 45.185 µM 0.181532270123116 0.429710857841509 no 1448 0.427974903007331 1968 2257073 SGTC_1381 2324-0066 62.1 µM 0.181096644760097 0.429879869394577 no 1449 0.428145859074739 1986 10885928 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.17904181655848 0.430677263197817 no 1450 0.428952433645836 1999 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1136 pergolide 1.05886 µM 0.177689777772363 0.431202087927842 no 1451 0.429483306824814 1945 47811 A dopamine receptor agonist. SGTC_3138 9097216 49.47 µM 0.175365652642789 0.432104533599469 no 1452 0.430396163777945 2155 25237486 SGTC_2076 5212012 200 µM 0.175197552366937 0.432169819859337 no 1453 0.430462203758656 2063 604802 SGTC_3119 9125183 49.47 µM 0.169213433859734 0.434495106588153 no 1454 0.432814381735338 2108 22695334 SGTC_2837 9008476 45.46 µM 0.169135106244848 0.434525558056372 no 1455 0.432845185956185 2022 2992805 SGTC_1259 0671-0132 43 µM 0.168803499920332 0.434654481123665 no 1456 0.432975602647927 1968 X1259 SGTC_1307 1187-1599 12.2 µM 0.168598088361228 0.434734345234706 no 1457 0.433056392152088 1979 1538471 SGTC_2291 7917025 104.35 µM 0.168566066804371 0.434746795471133 no 1458 0.433068986659964 1951 2964612 SGTC_232 clozapine 119 µM 0.166410916918838 0.43558488303053 no 1459 0.433916791640715 2038 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1378 2093-0007 380 nM 0.165733059926714 0.43584854581896 no 1460 0.434183513885474 2009 3618014 SGTC_2676 harmalol 100 µM 0.163918255406881 0.436554581693735 no 1461 0.434897747873453 2092 5459187 A monoamine oxidase inhibitor SGTC_1478 0453-0656 35.7 µM 0.16386856227999 0.43657391728018 no 1462 0.434917308086833 2088 5258496 SGTC_2760 etidronate 98.04 µM 0.162801406583898 0.436989183860052 no 1463 0.435337400375552 2011 3305 A chelator and antioxidant. SGTC_1166 k206-0078 225 µM 0.162519669310635 0.43709882902071 no 1464 0.435448320153613 2037 5404595 SGTC_769 0302-0231 76 µM 0.161592052080831 0.437459868742686 no 1465 0.43581355828686 2106 571869 YER009W NTF2 SGTC_3221 9128209 49.47 µM 0.159169785451074 0.438402888706198 no 1466 0.436767554034194 2026 16460723 SGTC_1287 0971-0001 34.6 µM 0.157972552538845 0.438869116604946 no 1467 0.437239213506088 2034 4665869 SGTC_1563 conessine 56.1 µM 0.156572090631259 0.439414593796663 no 1468 0.437791049831683 2120 441082 An anti-amoebic, histamine inhibitor. SGTC_1348 1493-0373 93.8 µM 0.155537963204565 0.439817458326328 no 1469 0.438198613891255 2074 3010129 SGTC_145 3737-0113 38.366 µM 0.15540939460614 0.439867549098512 no 1470 0.43824928916202 2147 6849351 SGTC_1619 st003326 88.7 µM 0.15511964517615 0.439980440010022 no 1471 0.438363497515549 2135 2849032 SGTC_2938 9059746 27.26 µM 0.154931106494978 0.440053900251503 no 1472 0.438437815146879 2070 6471769 SGTC_1852 st056254 31.4 µM 0.154897477710808 0.440067003236486 no 1473 0.438451071071845 2049 442583 SGTC_1343 1487-0095 224 µM 0.154671300516666 0.440155131718587 no 1474 0.438540228271337 2142 4560101 YGL055W OLE1 SGTC_1987 st072290 61.9 µM 0.154426939652991 0.440250348681963 no 1475 0.438636556829726 2023 54697379 SGTC_185 k048-0037 25.491 µM 0.153746336274108 0.440515568868508 no 1476 0.438904874020564 2142 6827589 SGTC_200 k038-0079 37.545 µM 0.153572249123596 0.440583412121126 no 1477 0.438973509659324 2077 3436683 SGTC_920 mycophenolic acid 780.421 nM 0.153446431382401 0.440632445457674 no 1478 0.43902311573247 2002 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_599 1935-0052 86.5 µM 0.153258559826677 0.440705663926653 no 1479 0.439097189502319 2106 9557311 SGTC_1771 st048882 4.1505 µM 0.150714774599173 0.441697242227636 no 1480 0.440100358963135 1946 4580403 SGTC_1943 st076331 65.2 µM 0.149784881421544 0.442059810097509 no 1481 0.440467168831132 2165 24208415 SGTC_879 0831-1030 162 µM 0.148479214187604 0.442568975156807 no 1482 0.440982294399476 2005 1549252 SGTC_2679 rapamycin 1 nM 0.147069677978385 0.44311875199867 no 1483 0.441538511530807 2067 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2264 7948757 110.76 µM 0.142236626660069 0.445004665144755 no 1484 0.443446550997723 2010 2971411 SGTC_1876 myriocin 605 nM 0.141456557629982 0.445309175052801 no 1485 0.443754638435009 2171 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_261 5-fluorouridine 15.376 µM 0.140577415891165 0.445652397928504 no 1486 0.444101895273499 2145 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3097 9117246 49.47 µM 0.139842723333997 0.445939258123639 no 1487 0.444392128298578 2172 16423892 SGTC_1272 0839-0021 27 µM 0.138549750083234 0.446444167262545 no 1488 0.444902976913216 2096 5027250 SGTC_1557 sumaresinolic acid 42.3 µM 0.138449536812561 0.446483304420472 no 1489 0.444942574612294 2067 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2507 purpurin 79.67 µM 0.138397139594991 0.446503767767952 no 1490 0.444963278768159 1986 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_338 4055-0136 114 µM 0.137078290684835 0.447018881275376 no 1491 0.445484455996768 2131 2900563 SGTC_2723 salbutamol 83.58 µM 0.13669500688097 0.447168600340353 no 1492 0.445635938208011 2148 9884233 β2-adrenoceptor agonist SGTC_1135 dihydrocapsaicin 536.708 nM 0.134277561444848 0.448113080223494 no 1493 0.446591547957486 2056 107982 A Capsaicinoid. SGTC_638 3970-0837 4.09 µM 0.134191670202298 0.448146642805689 no 1494 0.446625506276964 2044 4118451 YLR208W SEC13 SGTC_2898 9056270 58.44 µM 0.134046939305055 0.44820319821929 no 1495 0.446682728572758 2097 19154699 SGTC_236 1509-0011 5.31 µM 0.134035131824065 0.448207812187064 no 1496 0.446687396948853 2136 3107280 SGTC_2985 9022375 71.43 µM 0.132955845424859 0.448629590645323 no 1497 0.447114150318042 2084 4939335 SGTC_3083 9117465 49.47 µM 0.13277752845148 0.448699281419314 no 1498 0.447184663340129 2000 16420915 SGTC_422 cantharidin 155 µM 0.132485217704315 0.448813527260765 no 1499 0.447300257260367 2035 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3057 9095946 49.47 µM 0.132002328143768 0.449002267637773 no 1500 0.447491225136078 2181 24540043 SGTC_1702 st027038 51 µM 0.131652005418713 0.449139200671479 no 1501 0.447629774552885 2072 5521182 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.131366630073376 0.449250751757931 no 1502 0.447742642601846 2008 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2696 st077691 74.316 µM 0.130510780498329 0.449585320969949 no 1503 0.44808116274414 2098 757133 SGTC_2144 5628481 200 µM 0.130427432630361 0.449617905285861 no 1504 0.448114131931279 2060 2818399 SGTC_102 gallobenzophenone 83.616 µM 0.130075591893816 0.449755458912861 no 1505 0.448253310441268 2173 70837 SGTC_1558 st069300 45.6 µM 0.123092551383676 0.452486735928831 no 1506 0.451016904779866 2189 24208000 SGTC_1663 st014140 55.4 µM 0.121952482601951 0.452932868159338 no 1507 0.451468325337044 2207 4207120 SGTC_1465 k213-0056 144 µM 0.121555937988814 0.453088058133065 no 1508 0.451625355509573 2053 24048857 YMR208W ERG12 SGTC_2429 5902844 64.44 µM 0.120743261872291 0.453406125884273 no 1509 0.451947195814925 2178 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_502 l-744,832 89.3 µM 0.120639361242178 0.453446793001196 no 1510 0.451988345374852 2209 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2473 5854593 8.94 µM 0.120556781775309 0.453479115278843 no 1511 0.452021051114392 2050 2872951 SGTC_2923 7992654 58.14 µM 0.120233409137446 0.453605688934018 no 1512 0.452149126534352 2088 2985126 SGTC_2233 sulbentine 40.3845 µM 0.119405335885583 0.453929832612801 no 1513 0.452477117057959 2149 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1439 4092-1168 46 µM 0.118893033523514 0.454130385290835 no 1514 0.45268005052841 2171 2886240 SGTC_1870 st057514 26.5 µM 0.118753456414833 0.454185028026689 no 1515 0.452735342028051 2134 5393161 SGTC_1805 st050013 60.3 µM 0.118125695460295 0.454430799490369 no 1516 0.452984031976195 2157 4037144 SGTC_2529 gangaleoidin 93.61 µM 0.118086192586538 0.45444626564185 no 1517 0.452999681811328 2127 4565183 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.117886668039441 0.4545243844785 no 1518 0.453078728473472 2179 6312947 SGTC_2273 7815444 169.05 µM 0.115957828498034 0.455279663514693 no 1519 0.45384298212219 2224 2824616 SGTC_548 1436-0017 110 µM 0.115333873092794 0.455524021552211 no 1520 0.454090245325381 2200 9677137 SGTC_1030 k029-0042 36.7 µM 0.113546748961765 0.456224001143879 no 1521 0.454798551194676 2068 6080581 SGTC_1248 0469-0687 58.6 µM 0.113123433207693 0.456389825162915 no 1522 0.454966348611928 2132 4017482 SGTC_3306 9127676 59.7925 µM 0.110511806735073 0.457413035473714 no 1523 0.456001743401224 2070 41905287 SGTC_158 k038-0087 26.446 µM 0.110455238718621 0.457435201430938 no 1524 0.456024173458619 2092 X158 SGTC_2892 9047358 58.44 µM 0.110277540097584 0.457504832805373 no 1525 0.456094634508318 2116 6466771 SGTC_539 4859-0462 2.54 µM 0.109748131499571 0.457712289794404 no 1526 0.456304563759318 2242 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2450 5739737 12.93 µM 0.108738232999771 0.45810806612817 no 1527 0.456705058044786 2117 2262825 SGTC_978 1416-0512 87.4 µM 0.108150863290258 0.458338273768153 no 1528 0.456938010829649 2124 6814003 SGTC_1965 Pectolinarigenin 58.4 µM 0.106891158210394 0.458832036641342 no 1529 0.457437663864135 2148 5320438 An anti-inflammatory. SGTC_2566 crystal violet carbinol 226 nM 0.106723712323702 0.458897674709627 no 1530 0.457504085163995 1964 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_100 0086-0128 49.5915 µM 0.106232097971029 0.459090391892118 no 1531 0.457699102266096 2051 93297 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.10601632387075 0.459174980290071 no 1532 0.457784700300403 2163 7104 SGTC_2670 beta-carotene 100 µM 0.10380030278469 0.460043817686707 no 1533 0.458663913090599 2223 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_726 3448-4391 34.2 µM 0.102868392124362 0.460409249981765 no 1534 0.459033712007247 2169 1356692 SGTC_454 lyso-paf C-16 6.67 µM 0.101729584329164 0.460855858703371 no 1535 0.459485659529692 2107 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2330 7979373 200 µM 0.101211915570847 0.461058890341039 no 1536 0.459691119017361 2096 1863007 SGTC_167 3672-0051 66.205 µM 0.100350560099654 0.461396739673774 no 1537 0.460033009440313 2220 3237971 SGTC_3291 9121177 71.43 µM 0.0998634276484433 0.461587819914678 no 1538 0.460226375835868 2141 17015612 SGTC_1789 tunicamycin 25 nM 0.0992343302964686 0.461834599741125 no 1539 0.460476108868586 2214 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2630 antimycin a 100 µM 0.0991598252319707 0.461863827268818 no 1540 0.460505686208933 2214 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1472 k841-0093 193 µM 0.0987151243536969 0.462038282871758 no 1541 0.460682230011571 2209 X1472 SGTC_2702 st077768 96.8 µM 0.0986019780761676 0.462082671182963 no 1542 0.460727149699582 2123 6484119 SGTC_651 3253-0966 34.4 µM 0.0964647731597256 0.462921204155238 no 1543 0.46157572518077 2165 781462 SGTC_1827 berberine 7.24 µM 0.0959763459629693 0.4631128619761 no 1544 0.461769679504181 2071 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2717 st081029 62.2815 µM 0.0951153017212987 0.46345075477961 no 1545 0.46211162208175 2241 5292846 SGTC_2354 9060492 162 µM 0.0944774394270352 0.463701083066796 no 1546 0.462364951501058 2210 6471895 SGTC_2755 lomerizine 42.69 µM 0.0935830505849485 0.46405210907006 no 1547 0.462720187096074 2168 3949 A calcium channel blocker. SGTC_2620 irigenin 100 µM 0.0932153166612173 0.464196443881026 no 1548 0.462866253216785 2197 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1516 st013856 110 µM 0.0928386654915691 0.464344283577292 no 1549 0.463015866511509 2167 5281404 A mutagen and neurotoxin. SGTC_1968 st069590 43.6 µM 0.0918169046496252 0.464745360596039 no 1550 0.463421756414228 2223 6384066 SGTC_3240 9133527 49.47 µM 0.0916961302221017 0.464792771176203 no 1551 0.463469736037583 2202 17617455 SGTC_1396 3511-0007 98.6 µM 0.0915484904034424 0.464850728573282 no 1552 0.46352838910018 2163 X1396 SGTC_839 0122-0028 230 µM 0.0902462823876466 0.465361954714096 no 1553 0.464045753160707 2170 759448 SGTC_3176 9106582 49.47 µM 0.0897790296034835 0.465545404701943 no 1554 0.464231406417586 2237 17018027 SGTC_1265 0819-1001 68.8 µM 0.0892722489841089 0.465744382147922 no 1555 0.464432774047634 2257 3106768 SGTC_2897 9048598 12.99 µM 0.0888207155783263 0.465921675077748 no 1556 0.464612197053446 2203 6467404 SGTC_1531 st059297 52.4 µM 0.0887809968922167 0.465937270797808 no 1557 0.464627980164229 2196 7566702 SGTC_55 0767-0285 6.563 µM 0.0873913822414577 0.466482941976866 no 1558 0.465180209573576 2247 3116166 SGTC_2193 5925765 200 µM 0.0871390544460466 0.466582032354253 no 1559 0.465280491238176 2221 877370 SGTC_2948 9070189 9.45 µM 0.0852185751277448 0.467336281550558 no 1560 0.466043811740851 2263 6473636 YDL196W YDL196W SGTC_2053 5265679 138 µM 0.0850975772465836 0.467383806223891 no 1561 0.466091908199594 2227 764595 SGTC_1359 1582-0056 520 nM 0.0837514383864403 0.467912564123097 no 1562 0.466627029426188 2204 3661189 SGTC_2224 6650123 117.647 µM 0.0831053333660346 0.468166371727733 no 1563 0.466883892553018 2238 2908370 SGTC_558 k064-0027 21.3 µM 0.0828754515714884 0.468256678668231 no 1564 0.466975286842852 2212 5088526 SGTC_2751 anetholtrithion 17.25 µM 0.0826863529109639 0.468330965555791 no 1565 0.467050468254783 2229 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0826447886195641 0.468347294121022 no 1566 0.467066993448152 2160 4213774 SGTC_389 tpck 16.7 µM 0.0813301274573633 0.468863787147709 no 1567 0.467589707549736 2174 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_83 0170-0301 39.027 µM 0.0805581771297283 0.469167088979877 no 1568 0.467896663934938 2264 3089716 SGTC_2325 6158266 200 µM 0.0799673271231654 0.469399247996661 no 1569 0.468131620950954 2185 3623240 SGTC_1042 0350-0096 82 µM 0.0787764298729618 0.469867211381256 no 1570 0.468605226004635 2117 3122515 SGTC_2750 bromebric acid 70.15 µM 0.0774218088651681 0.470399560623306 no 1571 0.469143995943229 2202 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2851 9015922 71.43 µM 0.0772290248771815 0.470475326660233 no 1572 0.469220676040298 2244 2996893 SGTC_3338 9144300 39.5675 µM 0.0771901950356765 0.470490587306015 no 1573 0.469236120801527 2207 4901274 SGTC_523 1934-0222 13.7 µM 0.0771335762762393 0.470512839311548 no 1574 0.469258641275672 2238 1361595 SGTC_2841 9004761 38.96 µM 0.0769033735361223 0.470603313323051 no 1575 0.469350206901859 2167 2991039 SGTC_1084 voriconazole 435 nM 0.0765063997868874 0.470759335043319 no 1576 0.46950811130336 2269 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2735 sertaconazole 140 nM 0.0761830826915651 0.470886410968441 no 1577 0.469636720813916 2293 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1198 1612-1005 86.7 µM 0.0754804353240095 0.471162588333974 no 1578 0.469916231737268 2247 6998509 SGTC_745 0469-0705 296 µM 0.0746738237251188 0.47147964620062 no 1579 0.470237117575092 2267 3486736 SGTC_3151 9099821 49.47 µM 0.0734330142625562 0.471967411082408 no 1580 0.470730773460678 2209 17174189 SGTC_286 k060-0067 22.9 µM 0.0726832145026911 0.472262179416313 no 1581 0.471029103051111 2228 5985051 SGTC_1666 st014829 29 µM 0.07056711499707 0.473094161773315 no 1582 0.471871141785714 2258 3858230 SGTC_880 0833-0487 87.2 µM 0.0704714005294628 0.473131796429855 no 1583 0.471909231506392 2288 76075 SGTC_19 0279-0214 38.434 µM 0.0703555343931701 0.473177354986089 no 1584 0.471955340958566 2276 3566274 YBR002C RER2 SGTC_2132 5317594 122.667 µM 0.0698797637840315 0.473364431626305 no 1585 0.472144679954849 2215 794577 SGTC_2320 7373003 200 µM 0.0690307344365242 0.473698291024869 no 1586 0.472482577650457 2219 5415828 SGTC_3045 9092950 49.47 µM 0.0680671114002647 0.474077233874631 no 1587 0.472866105457889 2295 44120432 SGTC_2774 tamoxifen 10.92 µM 0.0672993139306497 0.474379185515419 no 1588 0.473171711528187 2276 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_346 4513-0042 7.16 µM 0.0670156273889121 0.474490754628758 no 1589 0.473284631155492 2288 2827372 SGTC_1356 1502-0781 85.8 µM 0.0658144048918046 0.474963197163337 no 1590 0.473762793828429 2258 567702 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0657783691692776 0.474977370612045 no 1591 0.473777138916994 2238 5379071 SGTC_3168 9103419 49.47 µM 0.0654409928202072 0.475110067872151 no 1592 0.473911443229904 2289 16649256 SGTC_1740 st038286 13.222 µM 0.0642947637024541 0.475560924586437 no 1593 0.474367761395138 2248 716786 SGTC_1611 st001856 99.4 µM 0.061916376407735 0.476496536448944 no 1594 0.475314713016123 2233 647478 SGTC_1824 st053723 68.6 µM 0.0615505149320151 0.476640470952972 no 1595 0.475460392767999 2220 675225 SGTC_535 2293-4129 48.2 µM 0.0607026958578383 0.476974025318033 no 1596 0.475797992329253 2302 396118 YIL048W NEO1 SGTC_1898 st060199 18.6 µM 0.0604467862787049 0.477074710070508 no 1597 0.475899898346605 2298 688866 SGTC_662 k832-1615 104 µM 0.0598016026310792 0.477328556818789 no 1598 0.476156824574168 2248 5878478 SGTC_2047 4141938 200 µM 0.0578537916883658 0.478094976135675 no 1599 0.47693254516174 2232 3807862 SGTC_1571 st070080 73.4 µM 0.0577795808548761 0.478124178031355 no 1600 0.476962101559462 2283 4315245 SGTC_645 0845-0943 5.41 µM 0.0574760408748625 0.47824362195918 no 1601 0.477082995581678 2246 1885106 SGTC_1401 3807-4679 7.6 µM 0.056848670154902 0.478490500473484 no 1602 0.477332871710116 2297 3291456 SGTC_372 0155-0182 15.9 µM 0.0565452234672957 0.47860991364755 no 1603 0.477453735006809 2227 771486 SGTC_866 0495-0101 262 µM 0.0564114070302884 0.478662574070156 no 1604 0.477507034965372 2197 635694 SGTC_2066 5222451 176 µM 0.0559755269190334 0.478834107376174 no 1605 0.477680651637877 2307 2281147 SGTC_1167 k781-0610 148 µM 0.0539851050845779 0.479617453848178 no 1606 0.47847351567809 2248 4525169 SGTC_1806 st050005 60.3 µM 0.0519847779236513 0.48040477795556 no 1607 0.479270411235188 2250 5194765 SGTC_1723 st034307 2.5525 µM 0.0515663152880808 0.480569493645094 no 1608 0.479437130060065 2293 867466 SGTC_827 3253-0474 693 µM 0.0510253537668216 0.480782432383513 no 1609 0.479652658737453 2305 5402065 SGTC_2390 9097792 176.6 µM 0.0487076123497874 0.481694826498999 no 1610 0.48057615465019 2211 4497149 SGTC_2062 5245942 200 µM 0.0485999827953001 0.48173719794597 no 1611 0.480619041838918 2325 1376160 SGTC_925 2064-1272 59.6 µM 0.0478892984256305 0.482016984294412 no 1612 0.480902234112769 2179 6815817 SGTC_3049 9092223 49.47 µM 0.0478288795546462 0.482040770756738 no 1613 0.480926310166132 2259 8623917 SGTC_2804 7954240 19.48 µM 0.0458354093912317 0.482825620553085 no 1614 0.481720717922487 2295 828705 SGTC_1507 4075-3230 155 µM 0.0456162658680354 0.482911903737584 no 1615 0.481808052189927 2329 659771 SGTC_2993 9054257 71.4286 µM 0.044938325092737 0.483178833805863 no 1616 0.482078234340422 2325 6470217 YGL055W OLE1 SGTC_2499 avocadenofuran 51.48 µM 0.0447450639334969 0.483254929176012 no 1617 0.482155256911313 2328 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_668 1682-0499 62.6 µM 0.0445824134234317 0.483318972267709 no 1618 0.482220080387838 2270 682214 SGTC_1058 3448-5425 97.3 µM 0.0443887416901234 0.483395230423003 no 1619 0.482297267817182 2322 7279705 SGTC_1897 st060201 15 µM 0.0415455499116964 0.484514804319625 no 1620 0.483430490300731 2230 611878 SGTC_683 panaxydol 45 µM 0.0401910638535716 0.485048208665237 no 1621 0.483970400943598 2309 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2020 4017018 200 µM 0.0401528804169535 0.485063245912889 no 1622 0.483985621644432 2304 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_132 0417-1715 25.805 µM 0.0395517497207974 0.485299983574991 no 1623 0.484225247728083 2344 6769098 SGTC_170 4197-0004 226 µM 0.0392952828055105 0.485400987115668 no 1624 0.484327483744652 2296 218692 SGTC_2317 5986382 200 µM 0.0387965528923968 0.485597402989685 no 1625 0.484526296580252 2312 877883 SGTC_707 0865-0008 204 µM 0.0380565953521487 0.485888828482858 no 1626 0.484821279055821 2306 723043 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0374110386565675 0.486143081229887 no 1627 0.485078635628972 2345 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.037067136993294 0.486278529335399 no 1628 0.485215737446163 2330 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1498 4478-3555 97.6 µM 0.0367482820059126 0.486404114044814 no 1629 0.485342855573094 2340 3437919 SGTC_1715 st032160 10.2275 µM 0.0367437209654687 0.48640591047294 no 1630 0.485344673936916 2323 5289825 SGTC_2949 9072542 2.23 µM 0.0364518243676016 0.486520878510189 no 1631 0.485461045870688 2299 16457352 SGTC_1199 1638-0010 4.46 µM 0.0341632437322734 0.487422309832861 no 1632 0.486373488336533 2322 3111136 SGTC_3011 9081274 71.4286 µM 0.0339641430152527 0.487500735178915 no 1633 0.48645287196131 2309 6625322 SGTC_3281 9140613 49.47 µM 0.0334575596966897 0.487700279435664 no 1634 0.486654854662118 2219 16013766 SGTC_2822 7994718 71.43 µM 0.0333731424551027 0.487733531869016 no 1635 0.486688513472252 2352 1018011 SGTC_643 k048-0106 28.4 µM 0.0328316628039153 0.487946825812462 no 1636 0.486904414275332 2323 6763920 SGTC_445 e6 berbamine 66 µM 0.0323885704933824 0.488121366621711 no 1637 0.487081088566239 2315 6610268 A calcium/calmodulin antagonist. SGTC_1612 st002233 45.4 µM 0.0293672422852153 0.489311572736569 no 1638 0.488285849199949 2347 1035021 SGTC_708 3448-5400 146 µM 0.0290884897846011 0.489421387985651 no 1639 0.488397007868055 2354 3462195 SGTC_2352 9027995 87.8 µM 0.0268583933080673 0.490299968277064 no 1640 0.489286339432675 2314 2997347 SGTC_1441 4106-0040 13 µM 0.0267745016103627 0.49033301962753 no 1641 0.489319795346252 2357 2904180 SGTC_2511 berberine 10.47 µM 0.0249726239574766 0.491042932578829 no 1642 0.490038399856906 2355 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_790 1575-0012 79.1 µM 0.0248114375844801 0.491106439024339 no 1643 0.490102683997313 2359 378741 YLR208W SEC13 SGTC_2836 9010338 19.48 µM 0.0236734465292951 0.491554806864633 no 1644 0.490556543334208 2355 2994051 SGTC_1173 0443-0020 122 µM 0.0232041352916082 0.491739718370301 no 1645 0.490743720005538 2337 5331295 SGTC_1950 st077106 7.18 µM 0.0226497456573822 0.491958153569856 no 1646 0.490964831346988 2259 13831864 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0213387991970287 0.492474689390389 no 1647 0.491487696797074 2369 77254 SGTC_2539 epi(13)torulosol 80 µM 0.020760910787688 0.492702391583681 no 1648 0.491718189842732 2350 6708597 SGTC_980 1473-0395 201 µM 0.0200398240403961 0.492986520757101 no 1649 0.492005801973119 2365 768876 SGTC_1413 3910-0535 34.4 µM 0.0198403624564318 0.493065115063056 no 1650 0.492085359814184 2364 2876951 SGTC_520 3584-0023 682 µM 0.0192757575062608 0.493287589097534 no 1651 0.4923105615216 2267 1340790 SGTC_1288 0973-0013 65.5 µM 0.0175840452389247 0.493954194934264 no 1652 0.492985342382671 2348 4315430 SGTC_1815 st051655 58.2 µM 0.0171425619117411 0.494128160800318 no 1653 0.493161442198881 2379 5984156 SGTC_441 propafenone 146 µM 0.0165393553948219 0.494365855253943 no 1654 0.493402052655512 2377 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1728 st035614 33.7865 µM 0.0161136317958874 0.494533613500456 no 1655 0.493571869163433 2294 15945546 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0160271582340672 0.494567688904862 no 1656 0.493606362668977 2372 364106 SGTC_1956 st077085 54 µM 0.0154526251634071 0.494794087960553 no 1657 0.493835539808789 2373 24208685 SGTC_472 calcifediol 10 µM 0.0148579531959361 0.495028424664317 no 1658 0.494072752352704 2333 5283731 A vitamin D metabolite. SGTC_792 4534-1957 155 µM 0.0144923080406517 0.495172511816018 no 1659 0.494218607957421 2311 1717904 SGTC_2969 9091408 28.7 µM 0.0138325676521682 0.495432492537759 no 1660 0.494481779893571 2345 4286311 SGTC_1284 0929-0043 16 µM 0.0137948676003262 0.495447348875505 no 1661 0.49449681860332 2368 1239883 SGTC_1201 1889-3372 45.9 µM 0.0133988398170241 0.495603410643416 no 1662 0.494654796225575 2341 5392199 SGTC_457 grayanotoxin iii 135 µM 0.0133053526178535 0.495640251030436 no 1663 0.494692088897598 2353 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1090 efavirenz 20.7 µM 0.0130940345525422 0.495723525020272 no 1664 0.494776385264428 2327 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1074 carmofur 3.8 µM 0.0129543313480648 0.495778577885165 no 1665 0.494832114052537 2379 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_92 0063-0024 660.874 µM 0.0127621790525602 0.495854299503156 no 1666 0.494908765390546 2378 3594437 SGTC_1646 st011709 75.6 µM 0.0117191234680819 0.496265339837355 no 1667 0.495324853172022 2377 5757843 SGTC_1433 4060-0023 7.6 µM 0.011508310965397 0.49634841590726 no 1668 0.495408949520841 2382 3840627 SGTC_2639 lactacystin 53 µM 0.0102271318500855 0.496853300649325 no 1669 0.495920035821334 2383 3870 A proteasome inhibitor. SGTC_776 4476-4378 112 µM 0.00967023523544042 0.497072763076244 no 1670 0.496142194429367 2303 2892008 SGTC_1196 1588-0294 184 µM 0.00807534037950603 0.497701285658427 no 1671 0.496778440307607 2373 6144269 SGTC_1693 xanthone 101.9 µM 0.00719606017418485 0.498047798479433 no 1672 0.497129212120696 2385 7020 An insecticide. SGTC_937 3122-0005 46.7 µM 0.00617344390788595 0.498450800000776 no 1673 0.497537167853135 2384 759535 SGTC_1249 0481-0015 10.2 µM 0.00609614683712025 0.498481261972804 no 1674 0.497568004342525 2399 4227577 SGTC_3196 9111891 49.47 µM 0.00604974278035661 0.498499549333435 no 1675 0.497586516541374 2396 18891510 SGTC_1329 1447-1697 50.6 µM 0.00604651518736579 0.498500821294694 no 1676 0.497587804141132 2360 2840515 SGTC_3327 9140648 26.9345 µM 0.00468013588189293 0.499039298555249 no 1677 0.498132902734739 2390 8029710 SGTC_229 benomyl 22.8748 µM 0.00226470244878792 0.499991201869548 no 1678 0.49909651521296 2401 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.00222005237268055 0.499991201869548 no 1679 0.499114327971358 2397 551469 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.00215012495915024 0.499963643999148 no 1680 0.49914222490657 2400 688667 SGTC_1483 3453-0561 55.9 µM 0.00147699245828863 0.499698367545871 no 1681 0.499410765474791 2401 4546991 SGTC_842 0271-0008 11.1 µM 0.000588236715840056 0.499348115819126 no 1682 0.499765327516701 2404 1221709 SGTC_2259 7964009 200 µM -0.000915181705628641 0.498755631596055 no 1683 0.499634895374341 2412 313134 SGTC_2106 5357045 167.29 µM -0.002068986698411 0.498300928800283 no 1684 0.499174594317302 2410 668842 SGTC_3322 9139058 2.11 µM -0.00240202067610735 0.49816968388618 no 1685 0.499041733315388 2436 4908926 YPR165W RHO1 SGTC_1129 3453-1384 223 µM -0.0027784865367702 0.498021323198781 no 1686 0.498891545671165 2418 1084452 SGTC_3195 9113082 49.47 µM -0.00370659625204944 0.497655567486103 no 1687 0.498521285424655 2414 17018038 SGTC_1424 4048-1941 275 µM -0.0047158731984942 0.497257827092457 no 1688 0.498118645765495 2416 X1424 SGTC_1219 1469-0211 33.1 µM -0.00489790501279636 0.497186091455865 no 1689 0.498046026417475 2411 6822282 SGTC_3093 9117344 49.47 µM -0.0052941783922408 0.497029927186437 no 1690 0.497887938265611 2440 24824913 SGTC_3020 9089140 49.47 µM -0.00573270093213807 0.49685711380807 no 1691 0.497712995743912 2418 17217859 SGTC_2324 6149169 200 µM -0.00653733369557081 0.496540024922977 no 1692 0.497391999763992 2420 2888231 SGTC_706 4262-0057 46.9 µM -0.00666004069212688 0.496491668858031 no 1693 0.497343047820756 2416 883298 SGTC_20 0481-0013 4.944 µM -0.00682225797870429 0.496427742756481 no 1694 0.497278333957015 2419 182045 SGTC_749 1000-0129 128 µM -0.00690239159165616 0.496396163976481 no 1695 0.497246366023453 2416 708470 SGTC_2129 girgensonine 121.053 µM -0.00815345552857102 0.495903152034293 no 1696 0.496747277897851 2429 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1333 1482-0047 286 µM -0.00816523524373308 0.495898509981751 no 1697 0.496742578627851 2421 3811116 SGTC_1804 st050076 49.1 µM -0.00838684792116089 0.495811178798359 no 1698 0.496654170988831 2417 3895976 SGTC_277 nystatin 15.5 µM -0.00841039144309635 0.495801900985114 no 1699 0.496644778813754 2417 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_829 1635-0120 117 µM -0.00887861295076344 0.495617389064623 no 1700 0.496457992438621 2427 285054 SGTC_2364 9055074 200 µM -0.00919825217116991 0.495491429461209 no 1701 0.496330480048227 2429 6470630 SGTC_227 fluconazole 33.516 µM -0.00975111736286897 0.495273564023021 no 1702 0.496109928650338 2425 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_270 tamoxifen 5.46 µM -0.0102114702666688 0.495092155615552 no 1703 0.49592628356289 2425 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2646 retinol 96.75 µM -0.0113224027571525 0.494654381606643 no 1704 0.495483111333093 2430 445354 A vitamin A analog and teratogen. SGTC_2057 5236571 38.335 µM -0.0127883736523874 0.494076711117721 no 1705 0.494898316109893 2430 54684039 YBR257W POP4 SGTC_332 4112-0506 40.9 µM -0.0149227273572543 0.493235684794923 no 1706 0.494046914065702 2435 2790355 SGTC_3261 9137475 49.47 µM -0.0170155024781739 0.492411071376819 no 1707 0.493212124186682 2434 17027690 SGTC_2046 4110841 106 µM -0.0178880482223416 0.492067272706194 no 1708 0.492864081813493 2439 44119630 YMR134W ERG29 SGTC_139 0099-0334 718.624 µM -0.018124328206162 0.491974175158581 no 1709 0.492769835017873 2442 97690 SGTC_350 k064-0020 19.8 µM -0.0197643997653767 0.49132797684223 no 1710 0.492115658602192 2441 2790705 SGTC_2493 resveratrol 26.09 µM -0.0205383373586925 0.49102304845424 no 1711 0.491806964864707 2429 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_956 1185-0240 191 µM -0.0210383627892232 0.490826043166693 no 1712 0.49160752668008 2463 1416193 SGTC_2765 myclobutanil 7.74 µM -0.0211012059554847 0.490801283711227 no 1713 0.491582461448322 2477 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1332 1480-0653 17.5 µM -0.0213494330342356 0.490703485560138 no 1714 0.491483455476032 2438 5749438 SGTC_1967 st070177 51.4 µM -0.0223809510461292 0.490297087304214 no 1715 0.491072037704749 2460 5729214 SGTC_3244 9134489 49.47 µM -0.0235459552089844 0.489838110206502 no 1716 0.490607390838598 2481 16584271 SGTC_1644 st010134 20.9 µM -0.0245507295423029 0.48944226969557 no 1717 0.490206659784329 2462 3818134 SGTC_3016 9080866 49.47 µM -0.0249744041980687 0.48927536208501 no 1718 0.490037689865102 2442 17066299 SGTC_2999 9069765 71.4286 µM -0.0252493427363903 0.489167050414941 no 1719 0.489928039836443 2464 2097066 SGTC_3336 9143619 71.43 µM -0.0259893320744681 0.4888755365943 no 1720 0.489632923674875 2446 45595730 SGTC_2420 aureobasidin a 50 nM -0.0264342729043901 0.488700257999157 no 1721 0.489455478934943 2482 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1486 3970-0793 4.53 µM -0.0272452750414926 0.488380779998786 no 1722 0.489132052416741 2458 2844330 SGTC_2791 5663188 71.43 µM -0.0273811479496568 0.488327256319656 no 1723 0.489077867184129 2477 54690634 SGTC_2388 9080168 200 µM -0.0288351571465257 0.487754499705605 no 1724 0.488498030590949 2458 15943073 SGTC_1446 4239-0190 62 µM -0.0297748088771842 0.487384369778755 no 1725 0.488123324730394 2465 1340085 SGTC_2840 9008771 71.43 µM -0.0302006490937522 0.48721663437327 no 1726 0.487953515433445 2497 2992978 SGTC_2705 st078069 42.8 µM -0.0303099217679776 0.487173593014432 no 1727 0.487909941891414 2489 1530061 SGTC_3250 9135583 49.47 µM -0.0303618948728464 0.487153121406624 no 1728 0.487889217160781 2490 7699353 SGTC_2127 5253358 187.912 µM -0.0306988995119455 0.487020379981926 no 1729 0.487754834406214 2463 20612 SGTC_725 1497-0963 19 µM -0.0316483906554461 0.486646396450914 no 1730 0.487376226268087 2458 3549977 SGTC_2024 5144227 134 µM -0.0322509973391941 0.486409049096302 no 1731 0.487135943656619 2478 3475211 SGTC_3173 9105693 49.47 µM -0.0325879504495324 0.486276336217141 no 1732 0.487001589438222 2494 17096658 SGTC_2978 9011784 42.97 µM -0.03434719172555 0.485583463714833 no 1733 0.48630014674759 2524 2994934 SGTC_1758 st042942 75.2445 µM -0.0343638697652152 0.485576895318172 no 1734 0.486293497097871 2458 669317 SGTC_2483 5729050 27.16 µM -0.035270773467083 0.485219730788888 no 1735 0.485931914109506 2488 2865180 SGTC_2605 digitonin 300 nM -0.0364101587128808 0.484771025241448 no 1736 0.485477657035026 2470 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2412 st077135 33.4 µM -0.0366328975185489 0.484683309878277 no 1737 0.485388856350049 2679 13258915 SGTC_125 0133-0007 11.75 µM -0.0377365785739707 0.484248687225651 no 1738 0.484948855635995 2504 26541 SGTC_2925 9010536 32.5 µM -0.0391244903828111 0.483702162917169 no 1739 0.484395567706376 2506 2994177 SGTC_2576 guaiol 23.12 µM -0.0408658551016041 0.483016501289297 no 1740 0.483701419188952 2529 227829 SGTC_1893 st059353 36.1 µM -0.0419022725957848 0.482608436047853 no 1741 0.483288302360714 2527 3112488 SGTC_2306 7482397 179.52 µM -0.042989565631157 0.482180359336637 no 1742 0.482854925792698 2494 891448 SGTC_306 1672-3436 11.6 µM -0.0430192353007374 0.482168678415745 no 1743 0.482843100247069 2528 6797378 SGTC_420 mitomycin C 81.9 mM -0.0434417414871585 0.482002339795023 no 1744 0.482674702097925 2482 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1053 3366-3204 134 µM -0.0441343888791966 0.481729654693417 no 1745 0.482398640559708 2505 3632071 YPR165W RHO1 SGTC_1416 3966-0321 25.3 µM -0.0442904966620537 0.481668198528669 no 1746 0.482336423403801 2503 582530 YLR208W SEC13 SGTC_53 0973-0023 39.979 µM -0.0447459927108862 0.48148888235259 no 1747 0.482154886753487 2471 674768 SGTC_2688 kanamycin b 96.69 µM -0.0448591759599652 0.481444325822391 no 1748 0.482109778465038 2499 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1704 st028805 70.8 µM -0.0449381950335683 0.481413218744093 no 1749 0.482078286174159 2507 2876101 SGTC_1308 1187-1617 41.4 µM -0.0454102881590704 0.481227374360914 no 1750 0.481890140341569 2474 2882570 SGTC_1520 flindersine 88 µM -0.0467052324538071 0.48071762709562 no 1751 0.481374080001898 2588 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_137 0438-0332 85.389 µM -0.0472051110793849 0.480520861180422 no 1752 0.481174877006447 2487 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2448 5185112 27.17 µM -0.0490048110144759 0.479812489650726 no 1753 0.480457730956474 2550 5718189 SGTC_1244 0416-0015 52.5 µM -0.0496493789412783 0.479558799652769 no 1754 0.480200898210342 2511 96201 SGTC_678 1218-2179 85.9 µM -0.0502733236800823 0.479313234445627 no 1755 0.479952290750225 2495 6820081 YOR116C RPO31 SGTC_1572 epiandrosterone 68.9 µM -0.0502962073136756 0.479304228309196 no 1756 0.479943173035879 2510 441302 A steroid. SGTC_293 4049-0273 38.5 µM -0.0509009412588034 0.479066231644629 no 1757 0.479702227733915 2502 1380311 SGTC_1321 1326-2144 215 µM -0.0512115184329945 0.478944005033905 no 1758 0.479578486753644 2535 3513030 SGTC_2228 7354201 200 µM -0.0515498911427949 0.478810841837116 no 1759 0.479443673643056 2518 753451 SGTC_2218 6965428 192.983 µM -0.0516597418389753 0.478767611701803 no 1760 0.479399907870031 2507 675684 SGTC_1719 st032227 49.2 µM -0.0517560158937898 0.478729724660561 no 1761 0.479361551390315 2522 3125804 SGTC_3262 9137218 49.47 µM -0.0523128590942612 0.478510592130158 no 1762 0.479139703635912 2476 17650664 SGTC_2683 piperine 63.03 µM -0.0526812909785633 0.478365608003803 no 1763 0.478992922979616 2500 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1496 4469-0713 57.4 µM -0.0529277705277921 0.478268615763984 no 1764 0.478894728860134 2492 746691 SGTC_2771 fluoxetine 41.05 µM -0.0547343552021382 0.477557745755724 no 1765 0.478175049441422 2565 3386 A selective serotonin reuptake inhibitor. SGTC_3276 9139060 49.47 µM -0.0554815175650421 0.477263766818527 no 1766 0.477877427057156 2492 4870619 SGTC_1448 4255-0083 152 µM -0.0561946761727284 0.476983178556946 no 1767 0.477593361130882 2573 5399660 SGTC_1350 1495-0454 146 µM -0.0564841139126341 0.476869304146048 no 1768 0.477478075290532 2545 1069057 SGTC_375 3970-0961 9.27 µM -0.0566593433378709 0.47680036399307 no 1769 0.477408280637553 2538 2898222 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0583224144911131 0.476146100181261 no 1770 0.476745906859704 2515 688798 SGTC_2593 nobiletin 86.24 µM -0.0586197668821445 0.476029126398778 no 1771 0.476627483030052 2561 72344 An anti-infammatory. SGTC_2945 9067681 61.76 µM -0.0586534413860189 0.476015879505377 no 1772 0.476614071921894 2495 16456930 SGTC_164 4100-3994 89.624 µM -0.0595763753170088 0.475652825657209 no 1773 0.476246517352254 2497 4615967 SGTC_1526 st051518 75 µM -0.0608792039337601 0.475140367388379 no 1774 0.475727705788436 2593 673993 SGTC_2464 5717415 7.67 µM -0.0616984689037449 0.474818136409934 no 1775 0.47540147964304 2523 5285744 SGTC_559 1550-0661 158 µM -0.0617749333592356 0.474788062463962 no 1776 0.475371032816952 2576 5830875 SGTC_2367 9070478 135.38 µM -0.0618487938943552 0.474759012792469 no 1777 0.475341622963554 2525 572802 SGTC_2867 9039098 71.43 µM -0.0636211847352729 0.474061964323203 no 1778 0.474635931466717 2508 6463460 SGTC_405 ebelactone b 50 µM -0.0642430411356095 0.473817418433065 no 1779 0.474388353142934 2548 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3339 9145883 14.936 µM -0.0662303770071531 0.473035962448978 no 1780 0.473597206253393 2542 2030670 SGTC_143 4032-1194 15.74 µM -0.0665809293105 0.472898129698303 no 1781 0.473457664128448 2500 1806963 SGTC_2372 9071633 200 µM -0.0666616942323451 0.472866374407556 no 1782 0.473425515010891 2516 21321366 SGTC_2091 4-phenylthiadiazole 200 µM -0.0675017639145915 0.472536084629212 no 1783 0.473091128914761 2559 270010 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0675244991150331 0.472527146103205 no 1784 0.473082079529224 2610 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_399 oxolinic acid 75 µM -0.0693868360544477 0.471795000825706 no 1785 0.472340853485629 2535 4628 A DNA gyrase inhibitor. SGTC_2769 toremifene 3.73 µM -0.0721689719264371 0.470701430926528 no 1786 0.471233718790611 2631 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_849 0386-0493 241 µM -0.0742125055031148 0.469898322558523 no 1787 0.470420647669597 2540 726119 SGTC_904 1141-0088 396 µM -0.0756168594651662 0.469346482460628 no 1788 0.469861961476956 2562 1378119 SGTC_447 ml7 120 µM -0.0761950195910059 0.46911931181425 no 1789 0.469631972481543 2561 4216 Selective myosin light chain kinase inhibitor. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0762190526663683 0.469109868956653 no 1790 0.469622412471933 2525 5355888 SGTC_2627 acetyl isogambogic acid 100 µM -0.0763054293262968 0.469075930767774 no 1791 0.469588053231134 2615 6857789 A caspase activator and apoptosis inducer. SGTC_1346 1488-2224 62.4 µM -0.076450379980497 0.469018978819633 no 1792 0.469530394710083 2519 3722427 SGTC_2970 9090938 41.86 µM -0.0764954987985585 0.469001251505079 no 1793 0.469512447461464 2566 17217104 SGTC_2868 9035608 32.47 µM -0.0771867956599636 0.468729646667193 no 1794 0.469237472922209 2515 6462614 SGTC_804 1595-0054 20.9 µM -0.0779748084493701 0.468420060694915 no 1795 0.468924045955903 2556 761523 Stimulates phospholipase C. SGTC_1579 chlormadinone acetate 49.4 µM -0.0785030815449603 0.468212529134809 no 1796 0.46871393953565 2552 45114258 A steroidal progestin. SGTC_813 k007-0158 173 µM -0.0797414261903077 0.467726080629628 no 1797 0.468221455502009 2601 6523916 SGTC_1838 st055369 84.5 µM -0.0811470794155566 0.467173968139102 no 1798 0.467662492576082 2536 676036 SGTC_1581 himbacine 57.9 µM -0.081208524762756 0.467149835067767 no 1799 0.467638060065041 2530 5281825 An alkaloid muscarinic receptor antagonist. SGTC_549 1661-1316 519 µM -0.0813892662022783 0.46707884835813 no 1800 0.467566192560482 2573 2857282 SGTC_3103 9120822 49.47 µM -0.0816213886409782 0.466987683152485 no 1801 0.467473896183248 2628 17141819 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0820431960199598 0.466822024343494 no 1802 0.467306181879423 2546 688664 SGTC_2939 9044578 71.43 µM -0.0821154644933595 0.466793642511137 no 1803 0.467277447883754 2569 2653634 SGTC_1754 st042065 16.137 µM -0.0823195565158742 0.466713490829874 no 1804 0.467196301673818 2599 1126236 YIL048W NEO1 SGTC_2944 9067346 25.62 µM -0.0827619112251271 0.466539772491031 no 1805 0.467020427812297 2616 6473075 SGTC_503 tyrphostin 8 294 µM -0.0834480928038852 0.466270312853954 no 1806 0.466747624651773 2548 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3025 9087895 49.47 µM -0.0840255276683242 0.466043569412927 no 1807 0.466518067695661 2578 17173641 SGTC_3298 9116858 71.43 µM -0.0857783389435718 0.46535535446881 no 1808 0.465821313009884 2654 2506942 SGTC_1023 4482-3888 16 µM -0.0861779251944733 0.465198477374472 no 1809 0.465662489278498 2567 3303168 SGTC_1230 0170-0365 3.77 µM -0.0861884257266457 0.46519435495066 no 1810 0.465658315700772 2631 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_607 4491-0986 66.8 µM -0.086205120853362 0.465187800586937 no 1811 0.465651680005914 2608 698981 YDR232W HEM1 SGTC_3285 9112818 20.8695 µM -0.0864716714157098 0.465083156399995 no 1812 0.465545737319092 2540 17017947 YPR165W RHO1 SGTC_2986 9022445 71.43 µM -0.0875203660498793 0.464671476414465 no 1813 0.465128948888708 2545 6459286 SGTC_700 3453-2283 142 µM -0.0883366045533156 0.464351076535524 no 1814 0.46480457321662 2651 565664 SGTC_1262 0737-0114 49.6 µM -0.0891598010540267 0.464027968830934 no 1815 0.464477456103556 2566 765919 SGTC_2236 dapsone 200 µM -0.0911664756194536 0.463240441383394 no 1816 0.463680156286138 2576 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_532 1548-0774 215 µM -0.0917332391107229 0.463018038740268 no 1817 0.463454993866005 2751 5932993 SGTC_1306 1185-0270 9.02 µM -0.0919464217272117 0.462934387120712 no 1818 0.463370304220893 2600 1548076 SGTC_615 k087-0205 167 µM -0.0925465694788861 0.462698901445502 no 1819 0.463131896428318 2588 9642773 SGTC_1931 st074438 57.1 µM -0.0926637842068522 0.462652910312363 no 1820 0.463085334596709 2534 2787313 SGTC_400 oxethazaine 37.5 µM -0.0927051656252271 0.462636673749076 no 1821 0.463068896555917 2636 4621 A local anesthetic. SGTC_606 k015-0008 38.6 µM -0.0942709633278339 0.462022357672668 no 1822 0.462446957539446 2618 1970475 SGTC_3235 9132602 49.47 µM -0.0948560376234455 0.461792836154154 no 1823 0.462214587949301 2662 4912240 SGTC_1903 st060211 78.3 µM -0.0948998252371458 0.461775659018193 no 1824 0.462197197667362 2591 688960 SGTC_1746 st038117 42 µM -0.0970135478312001 0.460946566990549 no 1825 0.461357817793265 2659 2898218 SGTC_3079 9117512 49.47 µM -0.0976244490400263 0.460706976974129 no 1826 0.461115254854966 2550 7185044 SGTC_2998 9066762 71.4286 µM -0.0981416171195673 0.460504159401821 no 1827 0.460909920666628 2671 4945196 SGTC_1837 st055472 66.5 µM -0.098592180981533 0.460327470348624 no 1828 0.460731039223059 2724 676091 SGTC_1203 3992-3522 103 µM -0.0990474604463162 0.460148940024009 no 1829 0.460550293677147 2763 5322312 SGTC_1479 0549-0158 134 µM -0.100037013062218 0.459760931060432 no 1830 0.460157470320828 2621 5440202 SGTC_2336 9001819 198.65 µM -0.100150479375366 0.459716442743772 no 1831 0.460112430001231 2709 2989602 SGTC_1703 st026983 48.3 µM -0.100826491041933 0.459451399913739 no 1832 0.459844098593049 2599 1104023 SGTC_1421 4029-0249 71.4 µM -0.101282026030683 0.459272809183404 no 1833 0.459663291983533 2665 2894095 SGTC_1909 st060837 51.5 µM -0.101369990075836 0.459238324165354 no 1834 0.459628379092217 2637 678937 SGTC_1957 st077035 62.4 µM -0.101880265940456 0.459038284030027 no 1835 0.459425856972605 2600 705593 SGTC_2684 capsaicin 100 µM -0.102617481119119 0.458749296677219 no 1836 0.459133284079297 2680 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2342 7990637 118.86 µM -0.1032767512184 0.458490882149468 no 1837 0.45887166338911 2666 2033102 YER133W GLC7 SGTC_1236 0330-0013 258 µM -0.105010953377383 0.457811209848944 no 1838 0.458183558619503 2633 4617066 SGTC_217 ketoconazole 989 nM -0.105447482344592 0.457640143817369 no 1839 0.458010370292063 2615 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3260 9137109 49.47 µM -0.105814145641234 0.457496462656873 no 1840 0.457864906601522 2558 17478346 SGTC_1785 bathophenanthroline 24 µM -0.106469592875381 0.457239632096583 no 1841 0.457604889812069 2612 72812 An iron chelator. SGTC_2981 9013952 38.96 µM -0.106485800599984 0.457233281484715 no 1842 0.457598460415596 2659 2996344 SGTC_2915 7971052 15.16 µM -0.106979766553442 0.457039737906063 no 1843 0.457402515787836 2588 5741558 SGTC_1889 st059080 5.18 µM -0.107078562163003 0.457001029463895 no 1844 0.457363327143814 2579 176925 Isolated from Daphnopsis sellowiana. SGTC_1678 st019265 80.2 µM -0.108080846432429 0.456608354343247 no 1845 0.456965780737603 2633 5367020 SGTC_48 0382-0018 55 µM -0.108870010405834 0.456299205326381 no 1846 0.456652796726825 2719 762596 SGTC_2567 aureobasidin a 60 nM -0.109847540344888 0.455916302063874 no 1847 0.456265143701013 2843 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1430 4049-0248 69.1 µM -0.109914442794271 0.455890097539759 no 1848 0.456238614126514 2661 22774488 SGTC_2178 5812956 200 µM -0.110322820714458 0.45573014718595 no 1849 0.456076679708848 2565 5403383 SGTC_2907 7721985 69.9 µM -0.111415271907317 0.455302299562065 no 1850 0.455643525114024 2643 3267881 SGTC_3152 9099253 49.47 µM -0.112471884521754 0.454888537069246 no 1851 0.455224630587369 2676 25236131 SGTC_743 1275-0778 158 µM -0.1138084006967 0.454365236353886 no 1852 0.4546948395364 2706 2849257 YMR203W TOM40 SGTC_2678 equilin 100 µM -0.113834537504038 0.454355003512028 no 1853 0.454684479783688 2664 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1546 5-methoxyflavanone 78.7 µM -0.115241868869376 0.453804063017047 no 1854 0.454126706584487 2670 147795 SGTC_762 1165-0429 115 µM -0.11530740029805 0.45377841100492 no 1855 0.454100736450095 2642 5967793 SGTC_2788 5282734 71.43 µM -0.115700524301885 0.453624528258958 no 1856 0.453944945355705 2714 743706 SGTC_2078 5212016 200 µM -0.115866688713274 0.453559487678302 no 1857 0.453879098197469 2574 1899708 SGTC_2894 9048625 32.47 µM -0.117743429662739 0.452824974905858 no 1858 0.453135477101789 2683 4092861 SGTC_1814 st052110 31.539 µM -0.117794017857557 0.452805178085153 no 1859 0.453115434803081 2653 674163 SGTC_2023 5144124 124 µM -0.118497918265618 0.45252973095063 no 1860 0.452836572229717 2638 2830192 SGTC_1025 k007-0731 70 µM -0.122602900579659 0.450923847041073 no 1861 0.451210778722428 2621 6256118 SGTC_3284 9108171 64.8615 µM -0.123503650467669 0.45057157694587 no 1862 0.45085414188408 2714 8687505 SGTC_2137 5261020 140 µM -0.124063323119555 0.4503527167583 no 1863 0.450632568832131 2614 763655 SGTC_897 1000-0139 31.4 µM -0.124172336201473 0.450310088908838 no 1864 0.450589412604119 2688 6151020 SGTC_3078 9116413 49.47 µM -0.124331700148191 0.450247773178069 no 1865 0.450526324467458 2602 17177322 SGTC_2033 5192550 145 µM -0.124705724200563 0.450101524202448 no 1866 0.450378262762433 2652 182073 SGTC_3094 9117742 49.47 µM -0.126312727277586 0.449473239409937 no 1867 0.449742191020657 2613 17149698 SGTC_2889 9059656 51.95 µM -0.128189269030982 0.448739734355349 no 1868 0.448999596039545 2723 3949838 SGTC_1733 st037357 54.9 µM -0.13030582197201 0.447912623759385 no 1869 0.44816223703866 2630 1272339 YGL099W LSG1 SGTC_2405 ticlatone 3.52 µM -0.130347331475552 0.44789640484843 no 1870 0.448145817182229 2588 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_18 0111-0177 500 nM -0.130594743716922 0.447799735851491 no 1871 0.448047950510748 2645 721752 SGTC_2852 9023854 51.95 µM -0.131095295421564 0.447604169602404 no 1872 0.447849961377548 2773 19798528 SGTC_2378 9074213 121.43 µM -0.131149860127881 0.44758285186459 no 1873 0.447828379538618 2644 657714 SGTC_3041 9091929 49.47 µM -0.132004662415304 0.447248911270857 no 1874 0.447490301974616 2766 25236887 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.132536991501394 0.447040968269763 no 1875 0.447279783050402 2681 2374 Ca(2+)-ATPase inhibitor. SGTC_2021 4019055 173 µM -0.133951194606758 0.446488610859685 no 1876 0.446720583791415 2746 44827708 YER133W GLC7 SGTC_3198 9112019 49.47 µM -0.13407775492773 0.446439184156941 no 1877 0.446670544898239 2644 45595555 SGTC_103 0844-0104 51.839 µM -0.134804942409405 0.446155205455794 no 1878 0.446383049016618 2783 5375804 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.135543758172161 0.445866714001687 no 1879 0.446090984718898 2623 756377 SGTC_907 3448-6986 75.5 µM -0.135630269085477 0.445832935246728 no 1880 0.446056787643736 2747 590582 SGTC_432 NS 1619 61.3 µM -0.136341535611755 0.445555231480887 no 1881 0.445775644883463 2811 4552 A K+/calcium channel activator. SGTC_3108 9121785 49.47 µM -0.137239190875723 0.445204793061997 no 1882 0.445420867063752 2585 17140271 SGTC_2284 7945075 39.21 µM -0.137830093373658 0.444974132156693 no 1883 0.445187350131539 2775 1245402 SGTC_80 0159-0065 512.242 µM -0.137925465251566 0.444936905146787 no 1884 0.44514966219417 2618 1548079 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.138011422874932 0.444903353268762 no 1885 0.445115694895975 2760 6708739 YPR165W RHO1 SGTC_365 0121-0052 13.6 µM -0.138718856182427 0.444627235519581 no 1886 0.444836158542434 2764 3101739 SGTC_3022 9087993 49.47 µM -0.139452939644311 0.444340744376189 no 1887 0.44454612060542 2661 17173644 SGTC_2043 5101342 149 µM -0.13976172056493 0.444220244961504 no 1888 0.444424129468942 2679 678451 SGTC_1228 0124-0032 52.5 µM -0.14053065436292 0.443920196802696 no 1889 0.444120367060982 2721 X1228 SGTC_1470 k295-0292 231 µM -0.140932006640379 0.443763596581094 no 1890 0.443961828421538 2762 5045612 SGTC_1227 3909-8010 46.6 µM -0.141189230251875 0.44366323730997 no 1891 0.443860226931041 2671 15982272 SGTC_233 rapamycin 362 pM -0.142011536031531 0.443342427857115 no 1892 0.443535446802592 2699 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_990 3985-0011 41.3 µM -0.14263347714881 0.443099812126073 no 1893 0.443289828424075 2738 5399565 YGL099W LSG1 SGTC_1603 st002045 67.8 µM -0.142852523340004 0.443014368514014 no 1894 0.443203327395142 2675 5887985 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.145282178091664 0.442066808748084 no 1895 0.442244042626717 2647 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2805 7950783 58.44 µM -0.145506816210745 0.441979217051729 no 1896 0.442155367233714 2780 1178958 YDL195W SEC31 SGTC_1886 st057356 49.9 µM -0.146429474298555 0.441619480721201 no 1897 0.44179118047389 2646 24207747 SGTC_3230 9131665 49.47 µM -0.148967418160014 0.440630207837986 no 1898 0.440789671297625 2650 15943720 SGTC_783 0848-0141 92.7 µM -0.14905051878739 0.440597822020335 no 1899 0.440756884960366 2659 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3289 9119912 71.43 µM -0.149653165790995 0.440362971484229 no 1900 0.440519130112791 2781 17014829 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.150054613614134 0.440206539570843 no 1901 0.44036076377605 2686 689007 SGTC_2872 9044037 25.97 µM -0.150253418726096 0.440129074765328 no 1902 0.440282341081334 2652 6465195 SGTC_2899 9053889 58.44 µM -0.15242571207426 0.439282786318901 no 1903 0.439425589356833 2682 6470052 SGTC_750 4073-0104 132 µM -0.152521354578292 0.439245531978491 no 1904 0.439387874477218 2741 22330957 SGTC_2623 humulene 100 µM -0.153790284648981 0.438751313741438 no 1905 0.438887547214828 2731 6187145 An anti-inflammatory. SGTC_998 3996-0085 177 µM -0.154523663859212 0.438465723380891 no 1906 0.438598427116572 2746 715391 SGTC_1222 0366-0074 1.18 µM -0.155523415216607 0.438076454803451 no 1907 0.438204347925092 2795 286520 SGTC_2406 ethylparaben 405.7 µM -0.156011363672063 0.437886486295369 no 1908 0.438012031994123 2670 8434 A possible steroid mimic. SGTC_487 nimodipine 119 µM -0.156306302653898 0.437771667338135 no 1909 0.437895794301799 2714 4497 L-type voltage-gated calcium channels inhibitor SGTC_1859 st055998 20 µM -0.156309356897033 0.437770478356839 no 1910 0.437894590629403 2681 676301 SGTC_1946 st076057 65.1 µM -0.156441999445274 0.437718842699192 no 1911 0.437842316965153 2679 953009 SGTC_858 0438-0351 2.77 µM -0.157234307139283 0.437410431894196 no 1912 0.437530095688328 2696 2799119 SGTC_537 1334-0398 209 µM -0.15724064457257 0.437407965161061 no 1913 0.437527598479856 2682 5846986 SGTC_2795 7780010 54.55 µM -0.159021933825043 0.43671472681091 no 1914 0.436825796512931 2807 953673 SGTC_1761 st044296 37 µM -0.159349881671393 0.436587117884701 no 1915 0.436696611449502 2673 1826700 SGTC_1999 st074831 12.5 µM -0.160173244955617 0.436266765246153 no 1916 0.4363723023478 2721 17112523 SGTC_2114 5491910 81.25 µM -0.160243488538421 0.436239436937356 no 1917 0.436344636545893 2792 2849228 SGTC_632 0781-2353 4.65 µM -0.160676241122071 0.436071080999036 no 1918 0.436174201554916 2777 6811515 YHR007C ERG11 SGTC_2700 st077718 96.8 µM -0.160829656951555 0.436011399638056 no 1919 0.436113783209853 2758 904970 SGTC_3110 9122132 49.47 µM -0.161652971234295 0.435691141334707 no 1920 0.435789570419388 2835 918317 SGTC_2389 9091542 195.52 µM -0.163165039685823 0.435103076809032 no 1921 0.435194245785812 2758 3626624 YOL127W RPL25 SGTC_1489 4065-0444 182 µM -0.164304124941981 0.434660165359458 no 1922 0.434745867295641 2705 2877968 SGTC_995 3931-2021 34.6 µM -0.164556501549839 0.434562044632824 no 1923 0.434646535546668 2802 730143 SGTC_3220 9131269 49.47 µM -0.165015629904998 0.434383551869229 no 1924 0.434465839910744 2654 17722206 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.165497775356162 0.434196125276397 no 1925 0.434276100349241 3046 5282309 SGTC_1254 0550-0035 264 µM -0.165674448652517 0.434127449963669 no 1926 0.43420657757895 2833 15121435 SGTC_462 ag-879 158 µM -0.165805831012197 0.434076381142719 no 1927 0.434154878580078 2809 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1425 4048-4433 7.33 µM -0.166988597263325 0.433616685058352 no 1928 0.433689510506654 2748 23734946 SGTC_2485 5633444 17.78 µM -0.167120659407485 0.433565363105673 no 1929 0.433637555377637 2799 5724239 SGTC_1921 5740136 50 µM -0.167154151378026 0.433552347643689 no 1930 0.433624379341502 2739 1774243 SGTC_1429 4049-0205 9.46 µM -0.168473274822766 0.4330397747304 no 1931 0.433105483375005 2685 22774478 SGTC_2028 5153890 36.43 µM -0.16852818085054 0.433018442284373 no 1932 0.433083887801637 2700 2830968 YPR165W RHO1 SGTC_847 0342-0274 5.54 µM -0.169569602478508 0.432613859429141 no 1933 0.432674315000646 2832 18097 SGTC_3258 9138477 49.47 µM -0.171762021957682 0.431762355729817 no 1934 0.431812311906102 2730 4970355 SGTC_3000 9075062 71.4286 µM -0.17243824493847 0.431499784374036 no 1935 0.431546503679744 2747 17057871 SGTC_141 0443-0274 32.331 µM -0.172561641181522 0.431451873974627 no 1936 0.431498002699123 2821 1627241 SGTC_3314 9135860 59.4275 µM -0.173224050141865 0.43119470124413 no 1937 0.431237660058729 2739 25252478 SGTC_327 1273-0057 3.96 µM -0.173949550855218 0.430913067330106 no 1938 0.430952555121742 2773 3108138 SGTC_2468 5987765 72.9 µM -0.174032997133693 0.430880676363061 no 1939 0.430919764975919 2762 26772094 SGTC_1724 st037281 8.293 µM -0.174060505280856 0.430869998751038 no 1940 0.430908955776688 2710 574124 YDL195W SEC31 SGTC_3215 9129942 49.47 µM -0.17460250825432 0.430659624215649 no 1941 0.430695988780693 2785 17682944 SGTC_940 3232-1287 54.8 µM -0.176931475659664 0.429755877011758 no 1942 0.42978110732094 2703 1585493 YIL048W NEO1 SGTC_2763 lisinopril 49.32 µM -0.179244437979342 0.428858704663981 no 1943 0.428872886120091 2715 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_305 1682-2595 20.8 µM -0.182208069366873 0.427709682661753 no 1944 0.427709720280303 2772 226033 SGTC_551 k048-0028 34.9 µM -0.182309331585214 0.427670433316207 no 1945 0.427669987930073 2885 6836383 SGTC_69 0096-0274 206.684 µM -0.182546508106627 0.427578506241734 no 1946 0.427576929630717 3018 6741392 SGTC_2249 haloperidol 116.36 µM -0.18265452346289 0.427536641951463 no 1947 0.427534550188268 2711 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_256 clotrimazole 625 nM -0.182804590079649 0.427478480905294 no 1948 0.427475673470545 2718 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1391 3442-0225 151 µM -0.184148003325193 0.426957887025756 no 1949 0.426948674565459 2731 5227075 SGTC_2677 mitomycin C 100 µM -0.184180675292908 0.426945227702213 no 1950 0.426935859510241 2746 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3015 9080845 49.47 µM -0.18553074114492 0.426422187090695 no 1951 0.426406385422551 2851 5296973 SGTC_2155 5570423 76 µM -0.185555483763579 0.426412602544711 no 1952 0.426396683000484 2747 797402 SGTC_885 0865-0106 16.8 µM -0.185976663570682 0.42624945683126 no 1953 0.42623153091487 2734 2793380 SGTC_561 1550-0330 72.9 µM -0.186837404758007 0.425916084506228 no 1954 0.425894059263919 2750 6812934 SGTC_3248 9135562 49.47 µM -0.187000518289242 0.425852915218909 no 1955 0.425830113288958 2779 17650701 SGTC_2237 6667747 47.222 µM -0.187489374633293 0.425663606296374 no 1956 0.425638476895291 2764 729940 YDL015C TSC13 SGTC_1649 st011737 51.3 µM -0.187898810863249 0.425505065882465 no 1957 0.425477987464539 2778 1761035 SGTC_326 k292-0812 17.5 µM -0.187916511059272 0.425498212348079 no 1958 0.425471049679697 2765 3579357 SGTC_3218 9131285 49.47 µM -0.187925018804009 0.425494918148441 no 1959 0.425467714984586 2845 17156417 SGTC_1792 st045773 43.6 µM -0.188069239590262 0.425439076636689 no 1960 0.425411187025383 2732 2919270 SGTC_625 k213-0058 121 µM -0.188142457863131 0.425410727488065 no 1961 0.425382489394246 2795 3655420 SGTC_1914 st062367 72.6 µM -0.189000225331407 0.42507864000829 no 1962 0.425046320092081 2767 978205 SGTC_2226 7298446 200 µM -0.189018464935681 0.425071579062215 no 1963 0.42503917236447 2817 3283010 SGTC_2522 biochanin a 4.94 µM -0.189088081103784 0.425044629355901 no 1964 0.425011891439545 2860 5280373 A possible chelator. SGTC_3125 9127534 49.47 µM -0.189136771819023 0.425025780487601 no 1965 0.424992810916641 2698 1639235 SGTC_989 1501-0895 10.3 µM -0.19041596472233 0.424530648250994 no 1966 0.424491594248048 2756 2830112 SGTC_2142 5622915 118.518 µM -0.190677490525881 0.424429435106504 no 1967 0.42438913753577 2770 5322196 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.190908090240994 0.424340194806395 no 1968 0.424298800827481 2896 23847180 SGTC_383 2324-0395 7.37 µM -0.193007464048608 0.423527932381983 no 1969 0.423476561267405 2875 3146421 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.19424525850043 0.423049173050932 no 1970 0.422991923263543 2790 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2050 5263056 171 µM -0.195186482314659 0.422685198560293 no 1971 0.422623480544966 2881 763468 YGL055W OLE1 SGTC_1330 1469-0054 61.8 µM -0.197571573814642 0.421763171659889 no 1972 0.421690138589982 2911 7102664 SGTC_1988 st071872 53.4 µM -0.199544197608126 0.421000919906144 no 1973 0.42091853687435 2776 16414116 SGTC_1390 3413-2614 145 µM -0.200572105673937 0.420603837779787 no 1974 0.420516585627656 2819 3421432 SGTC_1945 st075991 56.6 µM -0.201501355801932 0.420244936839193 no 1975 0.420153284698912 2818 1084980 SGTC_3226 9131256 49.47 µM -0.201564210065699 0.420220663253313 no 1976 0.420128713560756 2757 17178073 SGTC_1775 st081588 35.1725 µM -0.202919321907472 0.419697408755847 no 1977 0.419599045877367 2785 1426443 YGL099W LSG1 SGTC_1705 st027868 56.3335 µM -0.20466173480937 0.419024812937537 no 1978 0.418918209361416 2843 292948 SGTC_3074 9116018 49.47 µM -0.207475087860339 0.417939319402397 no 1979 0.417819423196046 2732 17027303 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.207620485639108 0.417883236582154 no 1980 0.417762653837818 2945 6728940 SGTC_1688 st021091 57.6 µM -0.20797509989956 0.417746461801627 no 1981 0.41762420482645 2803 3656366 SGTC_2117 5521686 200 µM -0.209476167281342 0.417167610241669 no 1982 0.41703826921596 2757 803312 SGTC_318 1488-0629 67.2 µM -0.209602046860331 0.417119075863659 no 1983 0.416989140983187 2856 3662576 SGTC_2850 9015429 58.44 µM -0.209784392461231 0.417048772575227 no 1984 0.416917977512489 2842 6457570 SGTC_2728 chlorpromazine 9.18 µM -0.210096494940622 0.416928447719746 no 1985 0.416796180532342 2744 2726 A thorazine and dopamine antagonist. SGTC_821 1114-0266 29.2 µM -0.21155783238545 0.416365162046941 no 1986 0.416226004758313 2859 3123235 SGTC_1915 st067105 30.6 µM -0.211797564882639 0.416272771363188 no 1987 0.416132484185037 2738 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2338 7999974 200 µM -0.211871881676823 0.416244131298207 no 1988 0.41610349388044 2860 315925 SGTC_2479 5617353 43.85 µM -0.212322105370657 0.416070634459437 no 1989 0.415927875482416 2933 2731746 SGTC_709 3807-1509 243 µM -0.212982898283131 0.415816022930145 no 1990 0.415670150926308 2748 1886677 YPL242C IQG1 SGTC_2004 4023728 41.89 µM -0.213179518249447 0.415740269686912 no 1991 0.415593471577545 2917 360084 YDR527W RBA50 SGTC_1772 st048439 82.2 µM -0.213671050692321 0.4155509070141 no 1992 0.415401794086327 2858 2927068 YDL195W SEC31 SGTC_2882 9058044 58.44 µM -0.214166836507913 0.41535992559669 no 1993 0.415208478346495 2890 18076804 SGTC_2055 5235184 200 µM -0.216217076849008 0.414570366285108 no 1994 0.414409271482827 2947 2836034 SGTC_2399 5884133 200 µM -0.216283430285281 0.414544818943411 no 1995 0.414383412063204 2809 722445 SGTC_1989 st071868 50.2 µM -0.216593557859353 0.414425418692244 no 1996 0.414262553326997 2931 16414057 SGTC_373 0844-0104 25.9 µM -0.21800718423925 0.41388126768934 no 1997 0.413711756919683 2903 5375804 SGTC_64 000l-0018 272.079 µM -0.218347781181889 0.413750185466171 no 1998 0.413579074221883 2759 6811119 SGTC_1139 k015-0024 46.9 µM -0.218764326288028 0.413589886879013 no 1999 0.413416818626788 2831 2766652 SGTC_237 nikkomycin 200 µM -0.219534133399842 0.413293680784852 no 2000 0.413116996847182 2947 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_786 4544-0069 423 µM -0.220844087537711 0.412789750631151 no 2001 0.412606917047777 2917 748821 YLR208W SEC13 SGTC_130 0136-0219 337.655 µM -0.221230667798985 0.41264106334286 no 2002 0.412456415674645 2766 234244 SGTC_197 4544-0043 41.561 µM -0.224689082618095 0.411311440860909 no 2003 0.411110579138661 2814 896523 SGTC_2583 asiatic acid 100 µM -0.224830915867431 0.411256933265001 no 2004 0.411055407170315 2958 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_218 alverine citrate 93.75 µM -0.226793708053117 0.410502793640574 no 2005 0.410292078241813 2934 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1362 1611-0397 101 µM -0.22861214062914 0.409804414646733 no 2006 0.409585193794045 2822 27816 SGTC_1731 st035964 63 µM -0.229467101805741 0.409476160847303 no 2007 0.409252943718716 2853 6739575 SGTC_3050 9093513 49.47 µM -0.231425606455512 0.408724452073624 no 2008 0.408492086983429 2818 25236664 SGTC_1795 st049545 62.3 µM -0.233940727484145 0.407759596701805 no 2009 0.407515497196797 2816 5291882 SGTC_1100 amiodarone 5.07 µM -0.234407633024981 0.407580542901835 no 2010 0.407334266705439 2930 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_608 k048-0125 159 µM -0.237008661599505 0.406583427701545 no 2011 0.406325035349299 2931 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3005 9076496 71.4286 µM -0.239217808707858 0.40573701705211 no 2012 0.405468347072446 2919 21368410 SGTC_33 0986-0033 35.816 µM -0.239524805122411 0.405619429491894 no 2013 0.40534933222898 2828 2848082 SGTC_671 0560-0003 407 µM -0.23956825768398 0.405602786725683 no 2014 0.405332487462721 2878 3238678 SGTC_943 3253-1379 105 µM -0.241484925921281 0.404868853780024 no 2015 0.404589649105762 3001 668464 SGTC_1879 gemcitabine 100 µM -0.24371587043415 0.404014999206618 no 2016 0.403725440554737 2851 60750 A nucleoside analog which inhibits DNA replication. SGTC_698 k064-0052 127 µM -0.243806937038926 0.403980154756819 no 2017 0.403690173726402 2809 5088751 SGTC_105 0111-0055 734.78 µM -0.244044989450457 0.403889073316732 no 2018 0.403597988268682 2918 5179370 SGTC_1104 tacrolimus 29.8 µM -0.244068494580671 0.403880080281012 no 2019 0.403588886230865 2845 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2029 5175081 200 µM -0.244479629954374 0.403722788581619 no 2020 0.403429688170756 2824 1380876 SGTC_1316 1272-0050 65.9 µM -0.244629813580811 0.403665335383173 no 2021 0.40337153870558 2840 7340392 SGTC_2077 5212015 200 µM -0.247452132221026 0.402586036773438 no 2022 0.402279166316557 2784 780900 SGTC_2138 5575593 77.673 µM -0.248478461504705 0.402193736020019 no 2023 0.401882116424738 2851 762213 SGTC_1794 st048918 76.9 µM -0.248781711996614 0.402077841376223 no 2024 0.401764819073639 2848 672303 SGTC_2270 7924575 90.91 µM -0.249510712827786 0.401799270996334 no 2025 0.401482877630591 3035 1262135 SGTC_1863 st057641 20.1 µM -0.249813515667005 0.401683576728106 no 2026 0.401365783543403 2840 3921635 SGTC_3282 9108498 15.4605 µM -0.250104470271409 0.40157241752558 no 2027 0.401253279521551 2947 16459645 SGTC_634 1611-4317 11.2 µM -0.250234226773981 0.401522846622886 no 2028 0.401203108943935 2838 2843522 SGTC_3266 9136860 49.47 µM -0.250770056829365 0.40131816015161 no 2029 0.40099594658179 2871 4871271 YPR165W RHO1 SGTC_1944 st076371 56.9 µM -0.251016389026469 0.401224070614747 no 2030 0.400900719080472 2853 24208455 SGTC_2373 9071805 200 µM -0.253047706506079 0.400448403387903 no 2031 0.400115674037674 2985 10149009 SGTC_2346 9031566 143.75 µM -0.253510003032398 0.400271928203498 no 2032 0.399937066140176 2961 4771086 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.254014575048635 0.400079338185519 no 2033 0.399742149031486 2986 6708760 SGTC_1952 st077036 64.1 µM -0.255983905709143 0.399327897563576 no 2034 0.398981632379797 2826 2937007 SGTC_581 0958-0271 211 µM -0.256207248773132 0.399242699684561 no 2035 0.398895405842689 2865 4591145 SGTC_2689 tacrolimus 100 µM -0.257878284886336 0.39860540805836 no 2036 0.398250422167792 2931 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1370 2001-0092 44.6 µM -0.25846909752234 0.398380151393679 no 2037 0.398022447717127 3075 790957 SGTC_3189 9110682 49.47 µM -0.258781747717949 0.398260962254063 no 2038 0.397901820747499 2966 17122418 SGTC_1683 st010134 710 nM -0.259555195227792 0.397966147836944 no 2039 0.397603450516176 2848 3818134 SGTC_2261 9010538 184.68 µM -0.260023060385352 0.39778784028359 no 2040 0.397422992817786 2977 6457250 SGTC_1529 apigenin 74 µM -0.260053410367056 0.397776274373876 no 2041 0.397411287450962 3095 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.260856689275543 0.397470189865205 no 2042 0.397101512827496 2856 66535 A nucleotide analog. SGTC_1182 1222-0449 220 µM -0.26141608774525 0.39725707177636 no 2043 0.396885826019366 2932 658318 SGTC_2295 7971645 200 µM -0.261722147867863 0.39714048281064 no 2044 0.396767832013758 2935 2978226 YKL099C UTP11 SGTC_3199 9111318 49.47 µM -0.262145161696729 0.396979357235343 no 2045 0.396604764923799 2997 8548020 SGTC_629 3448-6466 76.7 µM -0.262927209703071 0.396681522197938 no 2046 0.396303341817492 2907 573744 SGTC_1138 3761-0006 1.03 µM -0.264761486212312 0.395983193359383 no 2047 0.395596603952522 2851 12061087 SGTC_1437 4092-1038 11.6 µM -0.265185022058837 0.395821996036559 no 2048 0.395433466322393 2882 3977136 SGTC_3205 9113483 49.47 µM -0.265780600883954 0.395595349473879 no 2049 0.395204092143406 3065 17018033 SGTC_1650 st011916 45.8 µM -0.266264881639702 0.395411083231983 no 2050 0.3950176087446 2981 242528 SGTC_1600 coumarin 106 71.1 µM -0.268296119054983 0.394638463384874 no 2051 0.394235696648822 3046 100336 A hepatotoxic, DNA x-linker. SGTC_177 1327-0068 8.361 µM -0.268443909135704 0.394582264742214 no 2052 0.394178822373982 2927 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.269546858028526 0.394162926851945 no 2053 0.393754444256196 3045 5377381 SGTC_2496 diffractaic acid 79.83 µM -0.26966087423611 0.394119585215579 no 2054 0.393710581790709 3128 94870 An apoptosis inducer which activates caspases. SGTC_474 dl-dihydrosphingosine 5 µM -0.269949300681158 0.394009949867997 no 2055 0.393599629070345 3019 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3323 9138564 53.9225 µM -0.270887964111456 0.393653207584117 no 2056 0.39323860115067 3044 43912313 YNL103W MET4 SGTC_3165 9101544 49.47 µM -0.271556967497951 0.393399004982803 no 2057 0.392981345649586 2991 5002184 SGTC_881 0833-0569 170 µM -0.271822318816371 0.393298191471617 no 2058 0.392879321605601 2902 5418700 SGTC_1834 st055981 52.8 µM -0.272088329570006 0.393197134605506 no 2059 0.392777051403594 3034 471719 YDL150W RPC53 SGTC_2323 6148992 148.28 µM -0.272449595720843 0.393059901959769 no 2060 0.392638171269788 2924 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_609 0986-0026 86.3 µM -0.273301302050158 0.392736420500117 no 2061 0.392310807264754 2907 2848610 SGTC_739 1486-1183 203 µM -0.274393986731592 0.392321523004634 no 2062 0.391890931817944 3018 4346692 SGTC_3254 9136651 49.47 µM -0.275117114599726 0.392047015221544 no 2063 0.391613131602853 2922 16454030 SGTC_2275 7947463 200 µM -0.27662684369626 0.391474077737428 no 2064 0.391033325227586 3012 1225414 SGTC_2272 7805186 180 µM -0.276956688888781 0.391348933799806 no 2065 0.390906681474312 3039 2956062 YPR165W RHO1 SGTC_733 4069-0007 56.1 µM -0.27817369913816 0.390887295022102 no 2066 0.390439511713016 2915 5717425 YNL287W SEC21 SGTC_2122 5258151 111.688 µM -0.280231830214674 0.390106950696084 no 2067 0.389649823802259 2928 2173356 SGTC_571 k831-0106 44.2 µM -0.280301746835227 0.390080449431922 no 2068 0.389623005351082 2982 4783639 SGTC_850 0388-0143 75.9 µM -0.28113702644983 0.389763883772004 no 2069 0.389302651461531 2922 67273 SGTC_1695 st026914 34.495 µM -0.281879871050899 0.389482411811616 no 2070 0.389017812260407 2879 3289191 SGTC_781 4335-2806 94.4 µM -0.282072510337827 0.38940942813408 no 2071 0.38894395564087 3063 845254 SGTC_65 0798-0905 34.986 µM -0.282642590927386 0.389193469205489 no 2072 0.388725414060161 3302 3602145 SGTC_2589 lobaric acid 100 µM -0.283284632829017 0.388950290745328 no 2073 0.388479328121994 2926 73157 A novel microtubule depolymerizer. SGTC_456 gingerol 170 µM -0.284372295007443 0.388538429381907 no 2074 0.388062544162649 3088 442793 A herb. SGTC_2726 cimetidine 79.27 µM -0.284674325084391 0.388424082877218 no 2075 0.387946831356603 2908 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_166 k072-0058 166.424 µM -0.285968647302522 0.387934171029006 no 2076 0.387451067518306 3003 5846229 SGTC_2443 5493264 126.67 µM -0.286699086260203 0.387657772398026 no 2077 0.387171368645532 3073 5340055 SGTC_3129 9127257 49.47 µM -0.287556083739323 0.38733355650755 no 2078 0.386843282802482 2923 837894 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.287607580358817 0.387314077010722 no 2079 0.38682357083424 2933 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_947 3447-0010 211 µM -0.287780636045675 0.387248617750096 no 2080 0.386757330407807 2891 748350 SGTC_2987 9018338 71.43 µM -0.290560346522941 0.386197617578046 no 2081 0.385693795516985 2965 5055682 SGTC_1032 k061-1018 98.7 µM -0.290638644646749 0.386168025341627 no 2082 0.385663850555657 3112 4005393 SGTC_2010 4012422 159 µM -0.291868489441154 0.385703300968478 no 2083 0.385193588386476 2994 952393 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.292381984261344 0.385509313958978 no 2084 0.384997290600626 2916 6708784 An antioxidant flavonoid SGTC_584 0986-0246 15.4 µM -0.292452895115094 0.385482527652837 no 2085 0.384970185254181 2933 53315 YDR232W HEM1 SGTC_431 k089-0097 107 µM -0.292720499126539 0.385381446173381 no 2086 0.384867899920695 3035 5499420 SGTC_403 arphamenine a 50 µM -0.29349093094231 0.385090476140213 no 2087 0.384573465257588 2928 5487158 An arginine aminopeptidase inhibitor. SGTC_872 0588-0139 234 µM -0.293616320853581 0.38504312607821 no 2088 0.38452555149544 2914 2047100 SGTC_1026 k007-1105 30.6 µM -0.293902877289599 0.384934922332878 no 2089 0.384416059700569 2918 7066794 SGTC_90 0870-0863 4.608 µM -0.294489919140316 0.384713283246701 no 2090 0.384191782720414 2884 1738164 SGTC_810 3825-7150 143 µM -0.294787810330159 0.384600828103817 no 2091 0.384077989412057 3115 22330411 YGL099W LSG1 SGTC_2260 7964312 200 µM -0.294843508804393 0.384579802779094 no 2092 0.384056713914011 3098 231951 SGTC_2966 9084041 48.03 µM -0.295561297111307 0.384308879037816 no 2093 0.383782567065511 2842 17741380 SGTC_1998 st075797 76.8 µM -0.29557896642245 0.384302210602723 no 2094 0.38377581931011 3046 24208315 SGTC_3222 9128301 49.47 µM -0.295894199533475 0.384183246722169 no 2095 0.383655440466502 2944 4911358 SGTC_526 4469-0568 170 µM -0.296318089460044 0.384023294716372 no 2096 0.383493586279458 2918 2901964 SGTC_1235 benzylparaben 21.5 µM -0.296679040831554 0.383887107720061 no 2097 0.38335577998902 3014 7180 SGTC_2490 carminic acid 95.39 µM -0.296874211433585 0.383813475799643 no 2098 0.383281272671618 2885 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1844 rapamycin 4 nM -0.297248276510387 0.383672364171465 no 2099 0.383138483594735 2898 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3170 9103054 49.47 µM -0.297416039626361 0.383609082528624 no 2100 0.38307444978506 2982 16432970 SGTC_744 1594-0068 283 µM -0.298081890222969 0.383357948771869 no 2101 0.382820331577499 2957 668392 SGTC_1925 st057770 10.1 µM -0.300736065758095 0.382357381705465 no 2102 0.381807882317572 2938 5989122 SGTC_1556 plumbagin 1.48 µM -0.302267291068725 0.381780499319312 no 2103 0.381224155381984 2936 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1368 1852-0141 284 µM -0.304469004928504 0.380951473582318 no 2104 0.380385301503291 3051 2838987 SGTC_2652 actinonin 100 µM -0.304531447626136 0.380927969571615 no 2105 0.380361518990093 2927 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2395 5646831 180.19 µM -0.305233542082876 0.380663724965791 no 2106 0.380094143839918 3119 6808628 SGTC_2343 7990716 14.84 µM -0.305353464081859 0.380618595943902 no 2107 0.380048480265212 2921 6456862 SGTC_2744 captopril 92.04 µM -0.306828402241525 0.380063680550599 no 2108 0.379486994233458 3038 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1522 st012842 45.6 µM -0.3079158714499 0.379654700447165 no 2109 0.379073174250559 2866 3491067 YOR116C RPO31 SGTC_2610 ononetin 44.17 µM -0.308023604030913 0.379614191234211 no 2110 0.379032185779173 3002 259632 SGTC_1620 st003704 16.5 µM -0.310600363994406 0.378645682024262 no 2111 0.378052225219638 2998 2834414 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.310623245140663 0.378637085246649 no 2112 0.378043526856315 2927 23665772 A membrane-active detergent. SGTC_1114 scopoletin 1.73284 µM -0.311129097704068 0.378447044468659 no 2113 0.377851240690313 3087 5280460 A coumarin with genotoxic properties. SGTC_251 melphalan 456.522 µM -0.31289084302693 0.37778541445295 no 2114 0.37718179737347 3016 460612 A DNA alkylator. SGTC_988 1497-1057 103 µM -0.314144652195638 0.377314759914985 no 2115 0.376705588651218 3012 3533044 SGTC_2365 9042475 200 µM -0.314809298031892 0.37706533917829 no 2116 0.376453225812533 3081 6464479 SGTC_2919 7978188 46.38 µM -0.315084137781275 0.376962215422752 no 2117 0.376348885901524 3132 2980291 SGTC_2457 5731572 11.68 µM -0.315500204921702 0.376806117856992 no 2118 0.376190947747505 3094 2865357 SGTC_3133 9127736 49.47 µM -0.316361396878591 0.376483085042647 no 2119 0.375864107101994 3144 27243420 SGTC_2951 9072950 58.06 µM -0.316446094909297 0.376451319507193 no 2120 0.375831967205093 2972 16488155 SGTC_3241 9133421 49.47 µM -0.317222216079445 0.376160278472781 no 2121 0.375537496902397 3015 17018221 SGTC_49 0717-0965 32.132 µM -0.317303273570849 0.376129886431589 no 2122 0.375506746831027 3240 5889349 YGL099W LSG1 SGTC_144 4161-2749 112.381 µM -0.318626045462006 0.375634029381736 no 2123 0.375005050323449 2983 797501 YMR168C CEP3 SGTC_641 4092-0595 30 µM -0.318912632168313 0.375526625923011 no 2124 0.374896382509743 3044 786260 SGTC_1410 3909-8106 77.9 µM -0.31933818567193 0.375367159986925 no 2125 0.374735039655575 3059 1039210 SGTC_797 k781-0471 270 µM -0.319392065595789 0.375346971300071 no 2126 0.374714613374426 2971 23738129 SGTC_949 1165-0505 146 µM -0.319823885460082 0.375185181700598 no 2127 0.37455091994408 2966 6244267 SGTC_446 go6976 132 µM -0.321042146446516 0.374728855274737 no 2128 0.374089225889432 3104 3501 A protein kinase C inhibitor. SGTC_1969 st069479 40.1 µM -0.321242250935577 0.374653918490853 no 2129 0.374013407946041 3148 3895485 SGTC_646 4092-0839 27.3 µM -0.321778171328249 0.374453245911524 no 2130 0.373810376133855 3110 877796 SGTC_1158 4092-0494 91.8 µM -0.322645103718085 0.374128699637663 no 2131 0.373482015577751 3111 1148199 SGTC_3174 9107204 49.47 µM -0.322828187908346 0.374060171330402 no 2132 0.37341268208451 3100 3938802 SGTC_752 1896-0090 130 µM -0.323617741857448 0.373764687355518 no 2133 0.373113727082943 2953 772567 SGTC_2871 9038510 12.99 µM -0.323714914879762 0.373728326286164 no 2134 0.373076938974784 3181 4945164 SGTC_2680 butyl paraben 22.24 µM -0.325478281335471 0.373068689616691 no 2135 0.372409558777062 3007 7184 An antifungal and steroid mimetic. SGTC_320 4092-0846 5.34 µM -0.326361852913828 0.372738304633601 no 2136 0.372075297886366 3070 1359356 SGTC_2362 9071156 126 µM -0.327362227708904 0.37236435758829 no 2137 0.371696965916753 3136 653133 SGTC_1657 st012939 43.4 µM -0.327587332970836 0.372280228247488 no 2138 0.371611850368663 3122 24207257 SGTC_1281 0884-0031 11.8 µM -0.328231027050044 0.372039691957936 no 2139 0.371368494995218 3005 1548255 SGTC_1647 st011722 22.4 µM -0.328843152019122 0.371810998759107 no 2140 0.371137122347854 3137 2854783 SGTC_2649 anisomycin 9.56 µM -0.328963612143498 0.371765999528307 no 2141 0.371091595986482 3044 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_321 4534-3890 65.3 µM -0.329356761021254 0.371619146547149 no 2142 0.37094302295813 3089 699746 SGTC_2171 5739187 198.077 µM -0.329832861402602 0.371441333684903 no 2143 0.370763127875662 2912 2262761 SGTC_2481 5478948 45.16 µM -0.329886559715854 0.371421280284622 no 2144 0.370742839677558 3134 77792 SGTC_1357 1503-1303 39.5 µM -0.330978875188664 0.371013435673594 no 2145 0.370330221134655 3011 292895 SGTC_2878 9043973 25.97 µM -0.331757503930857 0.370722802618138 no 2146 0.370036187737839 3124 6465167 SGTC_1817 st052116 64.4 µM -0.332610741948669 0.370404405394787 no 2147 0.369714066870753 3124 4361398 SGTC_891 0929-0073 133 µM -0.334283229955834 0.369780551730826 no 2148 0.36908292192867 3119 5603632 SGTC_1635 st007035 42.4 µM -0.334331526486226 0.369762541754852 no 2149 0.369064701553574 3068 3716403 SGTC_201 4262-0159 12.803 µM -0.334604593471572 0.369660719321332 no 2150 0.368961689690701 3049 1341029 SGTC_656 4090-1979 187 µM -0.334849236372053 0.369569503548588 no 2151 0.368869408530206 3123 22330961 SGTC_714 4296-0578 26.1 µM -0.335320931196913 0.36939365157081 no 2152 0.368691503001668 2981 1589775 SGTC_38 0929-0051 58.268 µM -0.335489894008147 0.369330667393685 no 2153 0.368627783433424 3123 1379719 SGTC_2234 tolnaftate 200 µM -0.338283594426645 0.368289770750896 no 2154 0.367574742746754 3027 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3301 9125354 19.7965 µM -0.338386140089778 0.36825158189721 no 2155 0.367536108681046 2978 41905162 SGTC_3059 1327-0034 3 µM -0.338527350223418 0.368198996205159 no 2156 0.367482909975067 3005 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1664 st014217 9.02 µM -0.339237026819784 0.367934754880278 no 2157 0.367215588957934 3066 3982782 SGTC_1596 piperlongumine 63 µM -0.340233825286822 0.367563711999553 no 2158 0.366840223554589 3153 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1294 1000-1494 117 µM -0.340459821978262 0.367479605385707 no 2159 0.366755137441037 3039 712797 YDL207W GLE1 SGTC_716 1683-5115 658 µM -0.340898363353661 0.367316416576184 no 2160 0.366590048477483 3008 723597 SGTC_2833 9001315 45.46 µM -0.341505063514656 0.367090692493403 no 2161 0.366361696808399 2970 2989378 SGTC_3019 9081971 49.47 µM -0.341952451453028 0.366924270281534 no 2162 0.366193337863509 3169 16451803 SGTC_2602 kawain 100 µM -0.34241946312792 0.366750574983009 no 2163 0.366017621679736 3060 5369129 SGTC_2180 6301957 200 µM -0.343014836721647 0.366529177695845 no 2164 0.365793649235283 3144 845462 SGTC_2540 epiandrosterone 100 µM -0.343015204874573 0.3665290408072 no 2165 0.365793510754685 3027 441302 A steroid. SGTC_2314 7727897 200 µM -0.343763833952795 0.366250716572806 no 2166 0.365511950378908 2996 900724 SGTC_1662 st014054 52 µM -0.344643017378337 0.36592394485611 no 2167 0.365181380857151 3037 2838777 SGTC_411 enrofloxacin 100 µM -0.344747853012293 0.36588498641099 no 2168 0.365141969748279 3180 71188 A bacterial gyrase inhibitor. SGTC_2467 5474540 200 µM -0.345070961818676 0.365764923183822 no 2169 0.365020511648968 3012 5413519 SGTC_3008 9078912 71.4286 µM -0.345515036824532 0.365599931870294 no 2170 0.36485360389103 3043 16648731 SGTC_2242 6630449 61.2675 µM -0.345725259533749 0.365521834542524 no 2171 0.36477459958872 3151 691249 YDR170C SEC7 SGTC_856 0433-0016 11.3 µM -0.34722327707252 0.36496548551046 no 2172 0.364211792428669 3103 3911780 SGTC_513 4245-1575 41.7 µM -0.347533456221488 0.3648503234873 no 2173 0.364095294251191 3100 719745 SGTC_710 3448-4187 58 µM -0.347680561736473 0.364795711025627 no 2174 0.364040048233049 3053 3946412 SGTC_2864 9034755 47.6 µM -0.347681458012865 0.364795378294231 no 2175 0.364039711641807 3058 4930451 SGTC_516 3992-2719 87.3 µM -0.348148773850035 0.364621907010418 no 2176 0.363864228262296 2941 5350887 YDR037W KRS1 SGTC_730 1436-0052 41.2 µM -0.348778128227618 0.364388329560328 no 2177 0.363627942350984 3006 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2391 6285546 200 µM -0.349547108121346 0.364103000098565 no 2178 0.363339305593984 2987 846083 SGTC_360 0957-0399 1.01 µM -0.351251324888761 0.363470920248466 no 2179 0.362699904168906 3165 6752301 YPR165W RHO1 SGTC_1841 st054148 70 µM -0.352151994244967 0.363137019400141 no 2180 0.362362138413285 3101 675442 SGTC_376 3970-0862 59.1 µM -0.352234152815987 0.363106566317493 no 2181 0.362331332931356 3140 3135186 SGTC_929 2805-0021 398 µM -0.352605712315251 0.362968854039052 no 2182 0.362192027263487 3103 3098024 SGTC_760 0568-0725 82.9 µM -0.353236822664463 0.362734984216588 no 2183 0.361955452219367 3155 3916171 SGTC_128 0906-2981 13.371 µM -0.354083239744674 0.362421408816813 no 2184 0.361638251114616 3195 6740226 SGTC_2130 NSC 7 2.4545 µM -0.354187112060528 0.362382933192384 no 2185 0.361599330734741 3128 21448 SGTC_816 0325-0417 81.3 µM -0.354291971303288 0.362344093407614 no 2186 0.361560042011172 3074 68101 SGTC_602 3130-1533 38.1 µM -0.357145157802119 0.361287820301234 no 2187 0.360491569828532 3143 720941 SGTC_2480 5767542 37.17 µM -0.357176106692508 0.361276368545839 no 2188 0.360479985922139 3062 2867358 SGTC_939 1165-0479 45.3 µM -0.357685229264348 0.361088000088046 no 2189 0.360289444061208 3165 1377347 SGTC_2568 diosmetin 100 µM -0.358301184015755 0.360860150197803 no 2190 0.360058966066476 3198 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3116 9124943 49.47 µM -0.358367272042961 0.360835706285318 no 2191 0.360034240263431 3055 41905195 YPL160W CDC60 SGTC_906 1165-0455 526 µM -0.359706919732162 0.360340334813185 no 2192 0.359533158382153 3027 3252859 SGTC_987 1497-1013 404 µM -0.359797701025762 0.360306774409765 no 2193 0.359499211267888 3069 1676435 SGTC_2300 7976697 71.57 µM -0.360292015173825 0.360124053207507 no 2194 0.359314384952133 3014 2236109 SGTC_120 rhodamine 6G 52.259 µM -0.360513926468184 0.360042034994631 no 2195 0.359231422008871 3009 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3192 9110362 49.47 µM -0.360586511379381 0.360015209075503 no 2196 0.359204287120276 3052 16649480 SGTC_3032 9089427 49.47 µM -0.362976514278326 0.359132297995948 no 2197 0.358311214243658 3133 17173707 SGTC_525 k781-2675 26.7 µM -0.363006656806267 0.359121167582241 no 2198 0.358299955814752 3112 3651118 YDL195W SEC31 SGTC_2720 fluspirilene 36.88 µM -0.363775183138692 0.358837422375943 no 2199 0.358012947900213 3123 3396 An atypical antipsychotic. SGTC_2857 9024691 58.44 µM -0.364196864493089 0.358681767798962 no 2200 0.357855504112358 3129 16478292 SGTC_1471 k673-0312 37 µM -0.364392807482167 0.358609447655624 no 2201 0.357782352816199 3083 24099884 SGTC_803 4488-1585 147 µM -0.364479132987519 0.358577587583729 no 2202 0.357750126616542 3172 747204 SGTC_1282 0886-0010 32.4 µM -0.366451887571863 0.35784977357481 no 2203 0.357013953784042 3231 2836211 YNL267W PIK1 SGTC_740 k014-0057 261 µM -0.366522775494916 0.357823630286954 no 2204 0.356987510424605 3142 4012779 SGTC_2815 7968870 71.43 µM -0.366974339003342 0.3576571104593 no 2205 0.356819079582783 3027 2977326 YHR190W ERG9 SGTC_188 3229-0966 278.469 µM -0.368558854147528 0.357073014698348 no 2206 0.356228284647283 3173 5722370 SGTC_2215 7188065 200 µM -0.369749433267341 0.356634354783791 no 2207 0.355784597740889 3177 940217 SGTC_3356 9151811 4.48 µM -0.371966164366652 0.355818122285066 no 2208 0.354959020812843 3035 1859254 YPR165W RHO1 SGTC_3146 9095609 49.47 µM -0.373294142473801 0.355329457636629 no 2209 0.354464767763228 3104 17173999 SGTC_2458 5808907 16.39 µM -0.373564903743123 0.355229853026075 no 2210 0.35436402461736 3214 2731747 SGTC_2941 9056145 11.23 µM -0.373736479845801 0.355166740657816 no 2211 0.354300190936669 3101 2119517 SGTC_1007 4101-0031 70 µM -0.374075350701596 0.355042102441605 no 2212 0.354174128448183 3198 1146276 SGTC_1960 st011366 51.8 µM -0.374787218315722 0.354780324874858 no 2213 0.353909360436718 3034 3972846 SGTC_2187 6125751 200 µM -0.37491115373071 0.354734756674674 no 2214 0.353863271815414 3100 874498 SGTC_2736 butenafine 14.65 µM -0.374974167189529 0.354711588872881 no 2215 0.353839839435966 3072 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2694 st077685 81.9 µM -0.375739255458038 0.354430336094442 no 2216 0.353555375544477 3011 2838096 SGTC_1633 st005664 67.9 µM -0.378099186987767 0.353563306252319 no 2217 0.352678456127914 3016 2063822 SGTC_331 k048-0133 24.5 µM -0.379425988517469 0.353076177531063 no 2218 0.35218577738969 3070 6813582 SGTC_3035 9091303 49.47 µM -0.380732424590533 0.352596761032327 no 2219 0.35170090319826 3116 25237002 SGTC_719 2810-4230 27.3 µM -0.380892374852139 0.352538080927508 no 2220 0.35164155538201 3103 721079 SGTC_2708 st078559 56 µM -0.381000569595886 0.352498390084776 no 2221 0.35160141294135 3181 17250902 SGTC_2197 6588183 93.1375 µM -0.381116263463466 0.352455949992928 no 2222 0.351558490004655 3064 884136 SGTC_1463 k081-0032 34.1 µM -0.381610778799128 0.352274567170878 no 2223 0.351375043966636 3136 977755 SGTC_1068 loratadine 26.9 µM -0.382616893598992 0.351905639001683 no 2224 0.351001921237452 3115 3957 A H1 histamine antagonist. SGTC_2958 9077254 16.72 µM -0.382833846974588 0.351826103502073 no 2225 0.350921481799152 3283 16457351 SGTC_2150 5556613 200 µM -0.383015033546232 0.351759685145876 no 2226 0.350854308677971 3097 743190 SGTC_2332 7982454 138.89 µM -0.383160544559238 0.351706347811151 no 2227 0.350800365290659 3172 2981748 SGTC_2580 diallyl disulphide 81.36 µM -0.383557670362746 0.351560795459099 no 2228 0.350653159363067 3057 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1800 st050079 29.0735 µM -0.386107033188241 0.35062693613329 no 2229 0.349708700623363 3180 3645560 SGTC_391 gliotoxin 8.33 µM -0.387313354123699 0.35018536165944 no 2230 0.349262120207948 3251 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_231 b-estradiol 524 µM -0.389254664472 0.349475169161102 no 2231 0.348543884672665 3078 450 A steroid. SGTC_2827 7993847 71.43 µM -0.389555419550999 0.349365190523914 no 2232 0.348432661409316 3169 2985692 SGTC_354 2783-3500 4.88 µM -0.389941375810902 0.349224074465729 no 2233 0.348289948697457 3105 6740761 SGTC_3185 9108267 49.47 µM -0.393639505746806 0.347872997182183 no 2234 0.346923604944453 3189 4910486 SGTC_1040 k898-0338 155 µM -0.39447097002547 0.347569494503426 no 2235 0.346616677919742 3282 20969351 SGTC_1088 bifonazole 369 nM -0.394983070487459 0.347382615209397 no 2236 0.346427691044795 3179 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1312 1218-2183 165 µM -0.396479679417745 0.346836674929402 no 2237 0.345875597861581 3168 6744073 SGTC_2591 skatole 100 µM -0.399036287241096 0.345904798825944 no 2238 0.344933233382058 3215 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3134 9127454 49.47 µM -0.400340412053634 0.345429807951219 no 2239 0.344452903332013 3230 24262820 SGTC_2828 7998861 71.43 µM -0.401396580806667 0.345045306385507 no 2240 0.344064083178046 3208 2988188 SGTC_1456 k015-0012 13 µM -0.403169657270265 0.344400172079047 no 2241 0.343411709884051 3299 2989616 SGTC_2908 7930301 100 µM -0.404237526717382 0.344011845682505 no 2242 0.343019030326747 3109 2223178 SGTC_640 3381-0960 37.1 µM -0.405866976686262 0.343419619844523 no 2243 0.342420171729554 3189 1745025 SGTC_3204 9114183 49.47 µM -0.406188733647099 0.343302722214106 no 2244 0.342301965756854 3059 17027248 SGTC_1640 st009078 66.4 µM -0.406354660260763 0.343242445217542 no 2245 0.342241014241114 3218 690618 SGTC_1464 k208-0027 110 µM -0.407954529263936 0.342661457539398 no 2246 0.341653529086082 3311 X1464 SGTC_2116 5511452 16.8835 µM -0.408650265753706 0.342408918872043 no 2247 0.341398168398189 3238 870744 SGTC_2184 6075246 200 µM -0.408679921004012 0.342398156163714 no 2248 0.341387285451139 3190 2267320 SGTC_3206 9114350 49.47 µM -0.408735964339396 0.342377816840921 no 2249 0.341366718908471 3212 17087243 SGTC_497 capsazepine 133 µM -0.409492907992729 0.342103150635278 no 2250 0.341088985149718 3143 2733484 A calcium channel blocker. SGTC_2956 9076196 2.52 µM -0.409531859053585 0.342089019027793 no 2251 0.341074695760074 3256 16423868 SGTC_1050 3232-1156 69.3 µM -0.411744678645219 0.341286562574105 no 2252 0.340263286780157 3165 700529 SGTC_3249 9135183 49.47 µM -0.411975650527314 0.341202844249451 no 2253 0.340178635261576 3266 4902779 SGTC_1993 st073995 70.8 µM -0.413063171444589 0.340808765305847 no 2254 0.339780165629106 3141 3098394 SGTC_3024 9090631 49.47 µM -0.413906868914558 0.340503158911657 no 2255 0.339471156600987 3241 25236383 SGTC_219 mitoxanthrone 164.414 µM -0.415621947053095 0.339882241537031 no 2256 0.338843332188989 3156 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2877 9040724 71.43 µM -0.420597896688891 0.33808323830637 no 2257 0.337024364937023 3305 6463895 SGTC_1189 1431-2119 7.28 µM -0.420751964639874 0.338027595337056 no 2258 0.336968105628481 3220 3107275 SGTC_78 0336-0123 156.75 µM -0.421677636443709 0.337693355516079 no 2259 0.336630164997643 3013 6765896 SGTC_913 3487-1245 167 µM -0.424839275818889 0.336552723093837 no 2260 0.335476922028063 3088 4016153 SGTC_2810 7959871 45.46 µM -0.426947646486111 0.335792915214841 no 2261 0.334708730238787 3218 2974535 SGTC_3187 9109394 49.47 µM -0.428350547143266 0.335287713775058 no 2262 0.334197961564794 3183 17098090 SGTC_1819 st053448 58.6 µM -0.429060495026723 0.335032166386787 no 2263 0.33393960031424 3146 2857616 SGTC_2575 plumbagin 510 nM -0.429151811071776 0.33499930250383 no 2264 0.333906374672038 3097 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2545 solidagenone 89.61 µM -0.431069245651955 0.334309525891464 no 2265 0.333209010873263 3072 6708572 An anti ulcer agent SGTC_2428 5615643 7.78 µM -0.4313473198141 0.334209538048159 no 2266 0.333107924127108 3235 2253075 SGTC_1175 0741-0056 27.6 µM -0.43321751935502 0.33353737149077 no 2267 0.332428376234199 3334 765927 SGTC_1457 k015-0032 57.3 µM -0.433516411203088 0.33342999650866 no 2268 0.332319823097063 3199 4302660 SGTC_690 glyoxal 20.3 µM -0.435854491360429 0.332590527673938 no 2269 0.331471152614059 3237 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1802 st050112 57.9 µM -0.435943363861083 0.332558635241151 no 2270 0.331438910925379 3201 4662563 SGTC_702 1488-0190 94 µM -0.436169537414283 0.332477476964947 no 2271 0.33135686398804 3256 949357 SGTC_3227 9130768 49.47 µM -0.436219849182824 0.332459424567151 no 2272 0.331338613942448 3202 17720899 SGTC_109 0132-0036 33.701 µM -0.438103860877084 0.331783701182907 no 2273 0.330655497886717 3144 67274 A color developer. SGTC_253 dyclonine 31.25 µM -0.439334103106552 0.331342755055101 no 2274 0.330209733466448 3257 3180 An oral anasthetic. SGTC_495 decylubiquinone 155 µM -0.440446418764374 0.330944277578202 no 2275 0.329806905735526 3237 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1698 5-fluorocytosine 1.055 µM -0.440669855210773 0.330864256477208 no 2276 0.329726011485493 3296 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2980 9014342 25.29 µM -0.441287306658059 0.330643163790298 no 2277 0.329502507144397 3319 2996599 SGTC_758 0868-0029 16 µM -0.442679573203866 0.330144847635422 no 2278 0.328998759706171 3277 762687 SGTC_414 piperonyl butoxide 100 µM -0.443378674409069 0.329894740803278 no 2279 0.32874592913996 3170 5794 A potent inhibitor of cytochrome P450. SGTC_3315 9136395 68.55 µM -0.444046808372978 0.329655783695686 no 2280 0.328504371129879 3363 16876844 SGTC_1355 1499-0035 1.68 µM -0.446310193585541 0.328846804535755 no 2281 0.327686596978434 3178 1548538 SGTC_2359 9039622 200 µM -0.448502860395874 0.328063865432254 no 2282 0.32689516114222 3169 6463596 SGTC_1009 4106-0057 9.87 µM -0.451637154267497 0.326946009269657 no 2283 0.325765199662909 3340 2928005 SGTC_1873 rapamycin 2 nM -0.451710955522338 0.326919706464248 no 2284 0.325738612394355 3208 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_300 r073-0011 5.04 µM -0.451915201942349 0.326846917417763 no 2285 0.325665036228305 3297 2735780 SGTC_3316 9136639 10.545 µM -0.454630697737935 0.325879799930411 no 2286 0.324687473102779 3292 4903665 SGTC_3191 9110352 49.47 µM -0.4546428536896 0.325875473243269 no 2287 0.324683099736331 3268 17122424 SGTC_1979 st071809 45.3 µM -0.456246677188583 0.325304827635071 no 2288 0.324106301713005 3334 4976333 SGTC_843 0310-0051 143 µM -0.456298969458303 0.325286228760151 no 2289 0.324087502451721 3243 2065037 SGTC_1676 st018489 23.4 µM -0.456770186788941 0.32511864977559 no 2290 0.323918118344389 3203 3696235 SGTC_223 busulfan 5 mM -0.458411861187211 0.324535097657375 no 2291 0.323328285855217 3284 2478 A DNA alkylator. SGTC_3238 9133470 49.47 µM -0.458493035471601 0.324506254479947 no 2292 0.323299132481423 3323 3534688 SGTC_63 0099-0242 26.702 µM -0.45872325142915 0.324424458934565 no 2293 0.323216457373464 3321 3898502 YLR359W ADE13 SGTC_3153 9100258 49.47 µM -0.459977818080505 0.323978861343273 no 2294 0.322766071166505 3195 25236848 SGTC_2205 7238770 200 µM -0.460669413601082 0.323733327860008 no 2295 0.322517901211889 3320 279867 SGTC_359 0081-0058 15.9 µM -0.461140884423132 0.323565988037169 no 2296 0.322348765419385 3535 3494159 SGTC_1387 3342-1166 1.8 µM -0.461233105880301 0.323533259911869 no 2297 0.322315686123923 3247 3418228 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.462437992131981 0.323105787873619 no 2298 0.321883629857303 3193 15053 SGTC_1087 pterostilbene 9.05 µM -0.462847865034444 0.322960425516116 no 2299 0.321736709693002 3330 5281727 Similar to reservatol, lowers cholesterol. SGTC_59 0330-0160 1.33 µM -0.465522260860631 0.322012609579245 no 2300 0.320778749599443 3310 4293482 SGTC_604 1000-0114 314 µM -0.465578164232099 0.321992809534374 no 2301 0.32075873788834 3341 1572745 SGTC_1482 3346-2049 8.48 µM -0.465873313994857 0.321888280772431 no 2302 0.320653091862212 3307 3826804 SGTC_2149 5554786 194.827 µM -0.468512010450397 0.32095440023748 no 2303 0.319709242050671 3236 745063 YPR165W RHO1 SGTC_3186 9110464 49.47 µM -0.468521505579036 0.320951041786269 no 2304 0.31970584778859 3341 17018021 SGTC_1081 sertraline 6 µM -0.470063460296088 0.320405842991427 no 2305 0.319154839495735 3327 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2662 daunorubicin 22.37 µM -0.470205516345932 0.320355634795057 no 2306 0.319104096685151 3245 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_727 3032-0951 202 µM -0.471162234831732 0.320017578527573 no 2307 0.318762442535626 3258 3652836 SGTC_469 w7 172 µM -0.47161174069902 0.319858797292945 no 2308 0.318601972453518 3305 45115570 A P450 inhibitor. SGTC_480 am 92016 50 µM -0.471883415125698 0.319762848356732 no 2309 0.318505003295983 3275 2129 K+ channel blocker. SGTC_2058 5236698 133 µM -0.472709984817604 0.319470997815181 no 2310 0.3182100510121 3234 766665 SGTC_675 1309-0189 238 µM -0.472740099306125 0.319460366907546 no 2311 0.318199307163299 3260 4246530 SGTC_1656 st012921 11 µM -0.473637049348466 0.319143796914419 no 2312 0.317879375348705 3299 6732821 SGTC_1240 0356-0016 42.1 µM -0.473866828370166 0.319062719796853 no 2313 0.317797437658148 3244 4305613 SGTC_2546 rhodinyl acetate 100 µM -0.474660994503157 0.318782566366051 no 2314 0.317514311951408 3347 6708682 SGTC_1004 4084-0029 199 µM -0.475019401503376 0.318656167078689 no 2315 0.317386572319239 3340 716894 YLR208W SEC13 SGTC_2984 9022109 38.96 µM -0.475888878213687 0.318349616686801 no 2316 0.317076773018406 3364 6459207 SGTC_2185 6113692 200 µM -0.475907107133119 0.318343191067975 no 2317 0.317070279325849 3347 874150 SGTC_1046 2001-0062 216 µM -0.476903638549727 0.317992001063068 no 2318 0.316715370452661 3251 739778 SGTC_2103 5378138 10 µM -0.48009211049056 0.316869444500766 no 2319 0.315580948964598 3373 244142 SGTC_3091 9116372 49.47 µM -0.480244258166743 0.31681592029891 no 2320 0.315526859884089 3383 17169793 SGTC_2972 9093619 59.92 µM -0.481944798100126 0.316217946571204 no 2321 0.314922580595625 3196 25236256 SGTC_922 1866-0035 480 µM -0.482076387479146 0.316171694804902 no 2322 0.314875841514504 3227 3156169 SGTC_1484 3473-2379 286 µM -0.482297652043398 0.316093929990923 no 2323 0.314797257491188 3400 671917 SGTC_1591 genipin 88.4 µM -0.483663608198904 0.315614036407505 no 2324 0.314312312140656 3358 442424 A DNA cross-linking agent. SGTC_1749 st037932 54.2 µM -0.484497777007029 0.315321125411595 no 2325 0.314016320806966 3344 594497 SGTC_927 2425-1185 123 µM -0.484663459902075 0.315262961136034 no 2326 0.31395754513844 3191 730375 SGTC_1668 st014914 51.6 µM -0.485990317752222 0.314797322575088 no 2327 0.313487015371522 3351 2839556 SGTC_654 1124-0271 80.9 µM -0.486261416939862 0.314702221035069 no 2328 0.313390915589766 3258 5403748 SGTC_1986 st071812 45 µM -0.486499452654459 0.314618728287099 no 2329 0.313306546658146 3336 11838594 SGTC_1097 itavastatin 7.23 µM -0.487103474580508 0.314406905777874 no 2330 0.313092502118749 3297 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3317 9138495 8.753 µM -0.487140144718599 0.314394048011236 no 2331 0.313079509513276 3330 17020139 SGTC_89 0302-0250 142.109 µM -0.487601260735397 0.314232384663864 no 2332 0.312916151199248 3363 4203518 YLR208W SEC13 SGTC_3154 9100113 49.47 µM -0.489154543623987 0.31368807921626 no 2333 0.31236614427629 3232 25237525 SGTC_2642 cholecalciferol 100 µM -0.489255799806736 0.313652610820023 no 2334 0.312330304641976 3334 9821465 A vitamin D precursor, similar to steriods. SGTC_1162 k048-0130 20.1 µM -0.48950064555082 0.313566852451398 no 2335 0.312243648808277 3258 6797406 SGTC_337 1315-0038 354 µM -0.489515550089369 0.31356163239225 no 2336 0.312238374127586 3282 1626437 SGTC_2691 st077356 60.2 µM -0.489986186517015 0.313396819257989 no 2337 0.31207183681509 3388 2839272 SGTC_140 0062-0056 502.533 µM -0.490083424670089 0.313362771872814 no 2338 0.312037433340427 3228 3758964 SGTC_1452 4194-0072 190 µM -0.490220492255719 0.313314781140037 no 2339 0.311988940744502 3394 1343545 SGTC_1729 st035615 45.989 µM -0.490965762424871 0.31305389906128 no 2340 0.311725331614796 3307 17385451 SGTC_504 lovastatin 124 µM -0.491580485403885 0.312838785478313 no 2341 0.311507970837887 3300 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1716 st033144 30.6155 µM -0.491862209858368 0.312740221290521 no 2342 0.311408377427272 3424 674617 SGTC_2016 5121758 140 µM -0.492472113143529 0.312526886247347 no 2343 0.311192815638065 3332 2795203 SGTC_180 1486-1293 102.781 µM -0.493602984523277 0.312131490590116 no 2344 0.310793296303382 3439 4140536 SGTC_2286 7945697 125 µM -0.493943063721301 0.312012628250355 no 2345 0.310673195179212 3297 1245733 SGTC_1017 4239-0030 168 µM -0.494314505583136 0.311882826591507 no 2346 0.310542041181122 3267 1149593 SGTC_37 0566-0070 1.56 µM -0.494856472663735 0.311693476210338 no 2347 0.310350718904705 3312 1626686 SGTC_681 1642-0006 26.6 µM -0.494897112556092 0.311679279606118 no 2348 0.310336374497831 3368 4446530 SGTC_2937 9044753 11.33 µM -0.495025478189902 0.311634439886231 no 2349 0.310291067983322 3284 6465530 YGL099W LSG1 SGTC_2756 carbadox 75.1 µM -0.495933067159439 0.311317487433204 no 2350 0.30997081758471 3286 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1504 k297-0033 30 µM -0.496000482329046 0.311293949969165 no 2351 0.309947035322756 3194 4388117 SGTC_1455 4262-0120 131 µM -0.496962816494234 0.310958042885024 no 2352 0.309607636399932 3446 1529587 SGTC_1271 0832-2808 169 µM -0.497290683291219 0.310843635444102 no 2353 0.309492040396895 3395 3663794 SGTC_1171 0368-0077 21.4 µM -0.498893904862002 0.310284462937313 no 2354 0.308927064095864 3256 3239779 SGTC_50 0929-0078 56.389 µM -0.501848967523537 0.309254943616595 no 2355 0.30788688254833 3236 1377751 SGTC_2766 oltipraz 83.91 µM -0.501989427047103 0.309206045861463 no 2356 0.307837479141566 3381 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1839 st053978 48 µM -0.502029196932454 0.309192201503701 no 2357 0.307823491631846 3379 3788398 SGTC_2293 7624732 200 µM -0.502375201921995 0.309071764593159 no 2358 0.307701809625795 3319 894453 SGTC_2394 5221648 200 µM -0.504239437530714 0.308423217548906 no 2359 0.307046565015724 3384 788586 SGTC_1407 3909-7909 12.3 µM -0.505658564975689 0.307929919043686 no 2360 0.306548180378054 3357 4411780 SGTC_1107 amlodipine 47 µM -0.505672200834259 0.307925180806226 no 2361 0.306543393321572 3335 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1225 1216-0074 20.6 µM -0.506166005603725 0.307753613321756 no 2362 0.306370058583818 3304 4241466 SGTC_198 3454-2873 16.191 µM -0.506733088312323 0.30755663800292 no 2363 0.306171055355229 3302 710957 SGTC_728 3030-5151 22.5 µM -0.508011109310083 0.307112922797211 no 2364 0.305722776152842 3336 3125388 SGTC_62 0180-0423 3.232 µM -0.508132433627856 0.307070814955021 no 2365 0.305680235494904 3329 30102 YGL099W LSG1 SGTC_818 4072-2707 53.5 µM -0.509930978574571 0.306446895424214 no 2366 0.30504990896782 3274 882871 SGTC_840 0245-0196 390 µM -0.510126381736201 0.306379143336699 no 2367 0.304981461828534 3438 3827528 SGTC_1218 1348-1416 30.7 µM -0.510319478370968 0.306312197492896 no 2368 0.304913829337218 3343 6787668 SGTC_2561 acetosyringone 100 µM -0.510569005878765 0.306225696863401 no 2369 0.304826441687638 3245 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.510737146400191 0.306167415749271 no 2370 0.304767563055036 3370 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2348 9022543 33.42 µM -0.511153128943459 0.306023248352198 no 2371 0.304621918035119 3390 3162678 YDL140C RPO21 SGTC_1499 4480-0877 67.3 µM -0.512636469004705 0.305509410706207 no 2372 0.304102818898978 3362 2861909 SGTC_888 0916-0002 6.97 µM -0.512760808158742 0.305466356276227 no 2373 0.304059323965284 3434 2802138 YIL048W NEO1 SGTC_278 4092-0821 23.9 µM -0.513375090472866 0.30525369064073 no 2374 0.30384448328911 3367 877900 SGTC_1654 st012436 41.8 µM -0.514416330284727 0.304893361700989 no 2375 0.303480472159914 3369 4323132 SGTC_2214 7179297 48.276 µM -0.51774786481863 0.303741730808289 no 2376 0.302317098885066 3366 769744 SGTC_2007 4011539 71.82 µM -0.51814458246332 0.303604724543753 no 2377 0.302178698320569 3337 45595301 SGTC_931 2812-0076 566 µM -0.518242428448882 0.303570937717776 no 2378 0.302144567736409 3282 3450959 SGTC_1310 1188-0297 994 nM -0.518347341049861 0.303534712610976 no 2379 0.302107974101906 3319 1588352 SGTC_2154 5570129 200 µM -0.521218572662709 0.302544059979301 no 2380 0.301107258720044 3410 673366 SGTC_2312 7706453 155.7 µM -0.522780271416319 0.302005840872927 no 2381 0.300563585076457 3324 976098 SGTC_1397 3532-0190 20.1 µM -0.522922869966296 0.301956717575757 no 2382 0.300513964384507 3280 5322280 SGTC_2656 pseudo-anisatin 100 µM -0.522949040616473 0.301947702525914 no 2383 0.300504858061386 3350 6708809 A neurotoxin. SGTC_1404 3909-7820 48.3 µM -0.523120726995528 0.30188856441599 no 2384 0.300445121266761 3410 23741373 SGTC_941 3237-0776 460 µM -0.523703360498188 0.30168791261683 no 2385 0.300242438968267 3440 760008 SGTC_412 gemfibrozil 100 µM -0.524290930004444 0.301485621675149 no 2386 0.300038102191373 3406 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2213 7173844 200 µM -0.524301166367928 0.301482097997185 no 2387 0.300034542888435 3324 892728 SGTC_835 0312-0010 67.2 µM -0.524368329387788 0.301458978835053 no 2388 0.300011189997177 3330 1626196 SGTC_458 nppb 133 µM -0.524847994020054 0.301293889682532 no 2389 0.299844432311439 3482 4549 A chloride channel blocker. SGTC_2893 9048488 25.97 µM -0.525404137680784 0.301102529253025 no 2390 0.299651138879233 3330 6467338 SGTC_3335 9143315 29.6265 µM -0.525552298931933 0.301051558499448 no 2391 0.299599653441635 3317 4899691 SGTC_2478 5763493 32.33 µM -0.527634412994945 0.300335676869505 no 2392 0.298876551588485 3332 1365576 YLR208W SEC13 SGTC_471 1-acyl-paf 4 µM -0.530784307887532 0.299254131003344 no 2393 0.297784127697646 3311 16759367 SGTC_2638 epoxomicin 18 µM -0.531938801195454 0.298858167925762 no 2394 0.297384191228092 3393 9915668 A protesome inhibitor. SGTC_636 0kpi-0074 126 µM -0.532782073635147 0.298569096552277 no 2395 0.297092222204676 3379 616434 SGTC_3101 9120531 49.47 µM -0.53468245980682 0.297918116325258 no 2396 0.296434726201203 3497 24824904 SGTC_3325 9138760 55.175 µM -0.534775147430928 0.297886382592367 no 2397 0.296402675182145 3302 43844959 SGTC_2061 5245884 80.95 µM -0.534862694146785 0.297856410382734 no 2398 0.296372403328023 3349 573863 SGTC_1250 0485-0349 40.2 µM -0.535481384669696 0.29764463671279 no 2399 0.296158513280961 3324 6842794 YDL195W SEC31 SGTC_1328 1441-0025 69.2 µM -0.536704494658295 0.297226176590381 no 2400 0.295735875430238 3377 4562601 SGTC_536 3852-0578 10.6 µM -0.536877515820699 0.297167002928679 no 2401 0.295676111453288 3459 2869208 SGTC_2537 larixol 68.93 µM -0.537204735248434 0.297055107808352 no 2402 0.295563100374413 3439 6708759 SGTC_2299 7976368 114.88 µM -0.53725196549621 0.297038958664809 no 2403 0.2955467902043 3401 2979718 SGTC_1353 1498-1206 8.11 µM -0.539381534455067 0.296311226061369 no 2404 0.294811809870272 3472 6756808 SGTC_2002 4023503 131 µM -0.539822477356948 0.296160645903696 no 2405 0.294659732152465 3515 4736863 YCR052W RSC6 SGTC_771 0250-0039 27.3 µM -0.540270494126697 0.296007686017189 no 2406 0.294505251784252 3324 3005115 SGTC_427 1354-0053 47.3 µM -0.54222009155752 0.295342485827558 no 2407 0.293833448002921 3508 6813657 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.542349841470885 0.295298239742728 no 2408 0.293788763183745 3371 688761 SGTC_2435 5706476 10.6 µM -0.543164856184617 0.295020380944451 no 2409 0.293508150647243 3463 5725375 SGTC_1627 st003713 25.6 µM -0.544912185854625 0.294425079050459 no 2410 0.29290695740357 3406 16195070 YER133W GLC7 SGTC_2102 5377816 72.7585 µM -0.545175337487571 0.294335473362503 no 2411 0.292816465939113 3481 1379702 SGTC_2085 5307070 144.047 µM -0.545214700571801 0.294322070932672 no 2412 0.292802931045121 3341 2840351 SGTC_2222 6885208 172.143 µM -0.545603993764536 0.294189538705663 no 2413 0.292669089238771 3402 609514 SGTC_887 0885-0007 9.62 µM -0.545797342762614 0.29412372460041 no 2414 0.29260262502313 3453 5719458 SGTC_384 k007-0144 5.16 µM -0.547721989636028 0.293468964943863 no 2415 0.291941405376031 3393 6824886 SGTC_2883 9059145 45.46 µM -0.548995912134545 0.293035951634946 no 2416 0.29150412759351 3345 16476510 SGTC_1336 1486-0901 104 µM -0.549647518044258 0.292814581813749 no 2417 0.29128058002468 3416 5006114 SGTC_2426 5582046 32.21 µM -0.549873837940831 0.292737712413813 no 2418 0.291202954792307 3481 2251934 SGTC_3172 9105863 49.47 µM -0.553218373520356 0.291602837277198 no 2419 0.290056943544753 3398 2348785 SGTC_1193 1488-0126 41.5 µM -0.554530085241772 0.291158305072677 no 2420 0.289608060979173 3431 1384710 SGTC_2326 6164455 177.58 µM -0.55595269871579 0.290676546854133 no 2421 0.289121595549211 3395 2888790 SGTC_870 0573-2213 57.6 µM -0.557428003379651 0.29017733929831 no 2422 0.288617518500934 3464 3916321 SGTC_3267 9137951 49.47 µM -0.558558826254219 0.289794968245321 no 2423 0.28823142330568 3395 16643986 SGTC_1594 piperine 70.1 µM -0.558924018119567 0.289671534526129 no 2424 0.288106788444933 3422 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_191 3914-0123 66.505 µM -0.560604738904633 0.289103774471857 no 2425 0.287533510123605 3338 3144412 SGTC_1111 tnp00062 510.699 nM -0.560686485776609 0.289076173117966 no 2426 0.287505640780784 3509 676306 SGTC_2266 7929956 200 µM -0.560907640590113 0.289001507699392 no 2427 0.287430250545416 3469 2967153 SGTC_1408 3909-7976 48.8 µM -0.561741022928042 0.288720225973343 no 2428 0.28714623997131 3450 24152374 SGTC_3268 9137683 49.47 µM -0.561856644890974 0.288681211639555 no 2429 0.28710684735362 3402 1953228 SGTC_1216 1165-0504 9.65 µM -0.561962863147653 0.288645372587887 no 2430 0.287070660851375 3492 6304004 SGTC_1677 st019204 53.9 µM -0.562459386628753 0.288477868636834 no 2431 0.286901533572497 3418 3945625 SGTC_2080 5212524 12.4 µM -0.562698546517896 0.288397203553321 no 2432 0.286820087082608 3470 260183 SGTC_1149 3909-7961 23.3 µM -0.56331874701011 0.288188068681365 no 2433 0.286608927346973 3423 735261 SGTC_1082 camptothecin 424.86 nM -0.56529288922085 0.287522854280913 no 2434 0.285937282239425 3300 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1564 D-Arginine 115 µM -0.56573585501026 0.287373690647967 no 2435 0.285786678709984 3402 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_95 0471-0001 561.058 µM -0.566176591705046 0.287225313978442 no 2436 0.285636870500721 3415 4015405 SGTC_68 0986-0284 82.829 µM -0.567762992194514 0.286691543035859 no 2437 0.285097956012762 3441 423278 YIL048W NEO1 SGTC_1689 st020265 53.493 µM -0.570997803386788 0.285604596486878 no 2438 0.28400056592224 3496 5758320 YPR016C TIF6 SGTC_655 k060-0012 42 µM -0.572032950433046 0.285257185747807 no 2439 0.283649825892513 3404 5994525 SGTC_3177 9107506 49.47 µM -0.572218173255933 0.285195043457906 no 2440 0.283587088528657 3459 8897194 SGTC_974 1326-0144 138 µM -0.572863938578224 0.284978439546865 no 2441 0.283368411478558 3428 5411856 SGTC_652 0437-0092 114 µM -0.573507989291529 0.284762488926084 no 2442 0.283150395610165 3480 3091274 SGTC_169 k015-0017 16.025 µM -0.573586506568275 0.284736167374157 no 2443 0.283123822443615 3556 1840002 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.573644968027236 0.284716569940668 no 2444 0.283104037688932 3546 1377 SGTC_2957 9076800 11.52 µM -0.57367287400865 0.284707215532602 no 2445 0.283094593871934 3395 16459615 SGTC_2603 homopterocarpin 100 µM -0.57462181428467 0.284389207111016 no 2446 0.28277354777458 3466 101795 A weak amylase inhibitor. SGTC_409 arachidonic acid 100 µM -0.575387907818194 0.284132598091657 no 2447 0.282514490176334 3451 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1762 st045503 25.4615 µM -0.576097422949731 0.283895039263845 no 2448 0.282274666620769 3456 4645554 SGTC_552 k242-0005 476 µM -0.576878007558704 0.283633794931695 no 2449 0.282010934064678 3519 4088318 SGTC_3013 9080133 71.4286 µM -0.576918663928429 0.283620191303593 no 2450 0.281997200934944 3565 17050193 SGTC_647 0140-0236 81 µM -0.577792615417509 0.283327842590611 no 2451 0.281702070754726 3473 990837 SGTC_1778 st046819 58.9 µM -0.578659279966413 0.283038074236133 no 2452 0.281409548480656 3428 671715 SGTC_676 falcarinol 140 µM -0.579195716358554 0.282858788609413 no 2453 0.281228560444767 3561 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1882 5615643 20 µM -0.579422892702608 0.282782879083328 no 2454 0.281151930464141 3453 2253075 SGTC_1286 0929-0070 131 µM -0.580100949100368 0.282556369077481 no 2455 0.280923271883083 3527 1420408 SGTC_2797 7859098 81.82 µM -0.581524466820465 0.28208111591177 no 2456 0.28044351663939 3439 972681 SGTC_291 SEC14.278 35.5 µM -0.583398663158996 0.281455987551247 no 2457 0.279812478779974 3508 1068044 SGTC_1089 terbinafine 2.25 µM -0.583635521103694 0.28137703242699 no 2458 0.279732778273636 3500 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_138 0850-0259 40.9225 µM -0.586726497008635 0.2803476559772 no 2459 0.278693704549692 3531 6813004 SGTC_1747 st037496 66.6 µM -0.587292157512582 0.280159473706329 no 2460 0.278503753659742 3455 723305 SGTC_2118 5526350 200 µM -0.589218609460005 0.279519046917359 no 2461 0.277857317537139 3475 743594 SGTC_123 0083-0120 66.675 µM -0.591562529054431 0.278740797693126 no 2462 0.277071785963151 3440 16001701 SGTC_689 0833-0039 98 µM -0.592301374945279 0.278495698279006 no 2463 0.27682439768074 3485 5374726 SGTC_1524 corynanthine 62.1 µM -0.592391462107623 0.278465820595617 no 2464 0.276794241135195 3534 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2512 diallyl trisulfide 49.23 µM -0.593084034608386 0.278236178971753 no 2465 0.276562457260824 3507 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2244 6635614 200 µM -0.595478675060547 0.277442881827364 no 2466 0.275761774734282 3349 836499 SGTC_319 1348-1596 45.5 µM -0.595526250103229 0.277427132362244 no 2467 0.275745878882426 3556 5380505 SGTC_1883 5-benzylidenerhodanine 20 µM -0.596223779827827 0.277196269045711 no 2468 0.275512870817662 3492 1273210 SGTC_553 k007-0256 45.7 µM -0.596751619392974 0.277021631037408 no 2469 0.275336611720569 3502 6287000 SGTC_225 nsc-122657 1.016 µM -0.597005249949091 0.276937735429047 no 2470 0.275251937750363 3474 275685 SGTC_2369 9071472 200 µM -0.598097429930282 0.276576607646369 no 2471 0.274887462520167 3517 17296037 SGTC_208 k072-0098 12.366 µM -0.599646254387936 0.276064887114582 no 2472 0.274371006999119 3525 5948901 SGTC_1990 st072050 59.8 µM -0.600134963168295 0.275903517761364 no 2473 0.274208146522912 3486 17233948 SGTC_1868 st057644 42.7 µM -0.601682098569834 0.275392966634597 no 2474 0.273692884144374 3464 688665 SGTC_2842 9000675 19.48 µM -0.602020770465292 0.275281267736005 no 2475 0.273580155825304 3464 2989072 SGTC_1320 1313-0481 95.3 µM -0.602277071767327 0.275196750679052 no 2476 0.273494860170168 3559 6813365 YLR208W SEC13 SGTC_869 0564-0080 44.1 µM -0.602449755210555 0.275139814370898 no 2477 0.273437399498921 3477 6843321 SGTC_1385 3091-4834 14.1 µM -0.603473015894778 0.274802549129623 no 2478 0.273097030683963 3501 4072814 SGTC_3009 9080819 71.4286 µM -0.603623480674112 0.274752973348406 no 2479 0.273046999061507 3492 17027216 SGTC_2910 7948405 25.97 µM -0.604071878574682 0.274605259440018 no 2480 0.272897927501297 3500 2971328 SGTC_715 0868-0130 184 µM -0.606128485509557 0.273928262013011 no 2481 0.272214718358476 3594 2876258 SGTC_2441 5730946 39.09 µM -0.607816189126256 0.273373317835202 no 2482 0.27165469541134 3540 1774275 SGTC_1848 st056003 16.4 µM -0.608703510960114 0.273081775557829 no 2483 0.271360489713811 3576 146492 SGTC_999 SEC7.066 22.7 µM -0.60871951449249 0.273076518783501 no 2484 0.271355184945564 3529 740511 YDR170C SEC7 SGTC_977 1348-1378 135 µM -0.609361805565643 0.272865583070415 no 2485 0.271142324284314 3521 X977 SGTC_1923 st058458 19.1 µM -0.609430546817734 0.272843012447506 no 2486 0.271119547788861 3589 3534982 SGTC_280 3448-3607 3.04 µM -0.610079765326643 0.272629892590754 no 2487 0.270904484978612 3532 626179 SGTC_1005 4092-0690 4.4 µM -0.610745336419394 0.272411490456788 no 2488 0.270684093553106 3480 1529343 SGTC_2651 TUB2.036 5 µM -0.610903370341266 0.272359645586617 no 2489 0.270631776730454 3633 15992207 YFL037W TUB2 SGTC_1363 1636-0063 10.4 µM -0.613448591563121 0.271525331889658 no 2490 0.26978988246447 3551 6072185 SGTC_3193 9111931 49.47 µM -0.613532241595326 0.271497933351605 no 2491 0.269762235442064 3530 17087244 SGTC_2302 7771753 200 µM -0.613599702718743 0.271475838294439 no 2492 0.26973994002046 3509 2203047 SGTC_2802 7925815 54.55 µM -0.614002895506924 0.271343802133974 no 2493 0.269606706913853 3509 1262923 SGTC_2133 5320837 200 µM -0.61451616052024 0.271175766219641 no 2494 0.269437148688029 3532 2841355 SGTC_1497 4476-2978 41.3 µM -0.6148244789921 0.271074851937809 no 2495 0.269335320708778 3559 1528379 SGTC_3048 9093155 49.47 µM -0.615944581034217 0.270708394257022 no 2496 0.268965548396648 3534 25236002 SGTC_1014 4130-3005 69.3 µM -0.616499771666721 0.270526847298545 no 2497 0.268782361282843 3533 743608 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.616787404164472 0.270432815593526 no 2498 0.268687480572381 3502 4620898 SGTC_1787 fluconazole 80 µM -0.618329098067405 0.269929089545138 no 2499 0.268179212333934 3499 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2799 7812892 81.82 µM -0.61968790684826 0.269485508254574 no 2500 0.267731639467374 3557 20205235 SGTC_1468 k284-1086 134 µM -0.621436691053794 0.268915158209585 no 2501 0.267156168550903 3571 15996457 SGTC_3046 9092212 49.47 µM -0.622573890157448 0.268544596556359 no 2502 0.266782286739731 3550 25236637 SGTC_1653 st012112 65 µM -0.624185897710648 0.268019756510314 no 2503 0.26625275359298 3566 720429 SGTC_2318 6029776 164 µM -0.625278372349039 0.26766436065968 no 2504 0.265894186056484 3589 818325 SGTC_3245 9134821 49.47 µM -0.626067731279955 0.267407720083027 no 2505 0.265635258270741 3483 17014901 SGTC_930 2810-3379 265 µM -0.627808259643724 0.266842269155581 no 2506 0.265064777325548 3618 1015764 SGTC_1247 0448-0043 5.84 µM -0.628585055427745 0.266590104189684 no 2507 0.264810373359565 3569 3089013 YGL099W LSG1 SGTC_1192 1488-0095 21.4 µM -0.63168180535507 0.265586030316527 no 2508 0.263797409744305 3545 915875 SGTC_1797 st048695 56.8 µM -0.633454127759599 0.265012246077734 no 2509 0.263218563822892 3554 592262 YIL048W NEO1 SGTC_184 1494-0393 24.714 µM -0.634446968763941 0.264691092140291 no 2510 0.262894582675136 3564 3090647 SGTC_798 1287-0182 476 µM -0.635192826640649 0.264449960012665 no 2511 0.262651330571285 3617 1649755 SGTC_2194 5927483 104.545 µM -0.635302467927189 0.264414522959437 no 2512 0.262615582165118 3583 760979 SGTC_221 trifluoperazine 10.304 µM -0.635394749489999 0.264384698598945 no 2513 0.262585495805267 3591 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1469 k284-2957 126 µM -0.635655162846233 0.264300545174008 no 2514 0.262500603311192 3589 23884841 SGTC_1626 st003712 1.76 µM -0.635859727093951 0.264234449136412 no 2515 0.262433926995869 3553 24207035 SGTC_3213 9129884 49.47 µM -0.635951805384774 0.264204700789818 no 2516 0.262403917537913 3504 17190742 SGTC_600 1495-0418 41.6 µM -0.636663827977548 0.263974720516979 no 2517 0.262171919879684 3572 5377768 SGTC_2339 9000433 200 µM -0.636845906348823 0.263915926361891 no 2518 0.262112610332486 3504 2988954 SGTC_1609 st001574 46.4 µM -0.640107338921221 0.262863922838101 no 2519 0.261051409058625 3542 3960012 SGTC_73 0327-0325 16.231 µM -0.641035678867824 0.262564871214607 no 2520 0.260749751185697 3621 53298 SGTC_343 4130-2827 29.8 µM -0.643505765515557 0.261770016526369 no 2521 0.25994798743746 3571 1118244 SGTC_79 0052-0007 94.094 µM -0.644550690110988 0.261434139848394 no 2522 0.259609199192737 3639 2801472 SGTC_3313 9133968 57.047 µM -0.645470413711749 0.261138690539496 no 2523 0.259311192682969 3572 1494643 SGTC_2854 9024559 71.43 µM -0.646051083674436 0.260952246239088 no 2524 0.259123136543712 3560 3163529 SGTC_87 0100-0052 35.5 µM -0.647011254278579 0.260644100299897 no 2525 0.258812329851793 3666 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_82 0054-0107 293.755 µM -0.647260227655283 0.260564228281937 no 2526 0.258731768816337 3603 3104697 SGTC_836 0330-0104 1.35 µM -0.647615262411011 0.260450352995066 no 2527 0.258616911648795 3601 46494820 SGTC_1406 3909-7906 11.9 µM -0.648232831863734 0.260252332349587 no 2528 0.258417184893604 3602 X1406 SGTC_2290 7904846 200 µM -0.648715194523834 0.260097719086154 no 2529 0.258261240666266 3591 2962154 SGTC_1936 st074407 74.3 µM -0.649192298089422 0.259944838133131 no 2530 0.258107044659422 3602 809813 SGTC_2783 7738165 71.43 µM -0.650548812745895 0.259510415946868 no 2531 0.257668891078728 3523 17201110 SGTC_2727 riluzole 51.77 µM -0.650848769554562 0.259414405783656 no 2532 0.257572057337553 3582 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2733 amorolfine 100 µM -0.652664124643563 0.258833738803992 no 2533 0.256986417772563 3604 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2408 sulbentine 18.36 µM -0.653320382833924 0.258623990980059 no 2534 0.256774877306485 3548 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2227 7312221 64.1025 µM -0.6539916913552 0.258409523984015 no 2535 0.256558579287736 3615 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.658883099362428 0.256849622439665 no 2536 0.254985419704369 3653 5024745 SGTC_2092 5303694 80.6725 µM -0.65999863793674 0.256494557496048 no 2537 0.254627351708331 3596 1963699 SGTC_2170 morpholine 200 µM -0.661111121596963 0.256140719726329 no 2538 0.25427052673541 3614 121171 Reacts with secondary amines. SGTC_2806 7952793 58.44 µM -0.662058355987014 0.255839642086178 no 2539 0.253966911619553 3626 2972490 SGTC_2887 9044784 58.44 µM -0.663002891019857 0.255539606462701 no 2540 0.253664351254919 3628 6465546 SGTC_2734 clemastine 41.6 µM -0.663056546139392 0.255522568201809 no 2541 0.253647169738966 3591 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2934 9036370 36.88 µM -0.663113194128953 0.25550458019479 no 2542 0.253629030505408 3604 6462800 SGTC_2487 5918373 44.05 µM -0.663271994473597 0.255454158247919 no 2543 0.253578184733194 3660 2876279 SGTC_2881 9058953 51.95 µM -0.663684674206333 0.255323149375169 no 2544 0.253446075178342 3585 17122249 SGTC_1263 0774-1208 64.8 µM -0.664749541386298 0.254985260063506 no 2545 0.253105350548488 3657 906585 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.665175404622328 0.254850196398918 no 2546 0.252969154937305 3588 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1686 st019653 115.5 µM -0.666478186629194 0.25443724821493 no 2547 0.252552750901544 3633 97252 SGTC_1092 toremifene 6.32 µM -0.667483131960922 0.25411894627889 no 2548 0.252231790336189 3628 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_721 1187-1332 279 µM -0.668226425164832 0.253883653318962 no 2549 0.251994534973689 3570 25730 SGTC_3310 9130229 44.1445 µM -0.669048510139103 0.253623551687036 no 2550 0.251732266894307 3628 7761258 SGTC_1958 st076513 41.9 µM -0.669993629463915 0.253324695935891 no 2551 0.251430925626086 3584 732122 YGL099W LSG1 SGTC_1212 0520-0165 585 µM -0.671981098002826 0.25269684389875 no 2552 0.250797864886856 3760 5403258 SGTC_895 0964-0006 13.7 µM -0.672402237719354 0.25256390888955 no 2553 0.250663829306408 3612 6738897 SGTC_2698 st077697 67.5 µM -0.67317467371984 0.252320181116928 no 2554 0.250418085769755 3583 3154499 SGTC_2762 leflunomide 42.06 µM -0.674265750225171 0.251976123661919 no 2555 0.250071187319999 3629 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1141 3253-0389 52.6 µM -0.675400106897348 0.251618681011083 no 2556 0.249710798805155 3619 5402031 SGTC_1159 4092-0538 61.2 µM -0.675442859530447 0.25160521463724 no 2557 0.249697221561057 3677 717301 SGTC_3132 9126706 49.47 µM -0.676791586936438 0.251180583292414 no 2558 0.249269098388516 3649 850858 SGTC_2313 7726885 200 µM -0.677219719067887 0.25104587010096 no 2559 0.249133279132515 3625 726423 SGTC_2136 5328288 199.296 µM -0.680221090442398 0.25010255298902 no 2560 0.248182240049478 3623 262395 SGTC_1568 digitonin 820 nM -0.680916443802423 0.249884275238023 no 2561 0.247962181272085 3653 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1616 st002734 56.1 µM -0.681892144007997 0.249578164632603 no 2562 0.247653576651522 3628 4026101 SGTC_1849 st056239 19.2 µM -0.682939285375969 0.249249862245475 no 2563 0.247322604227018 3612 5393181 SGTC_1467 k284-1082 293 µM -0.683049045357181 0.249215463322503 no 2564 0.247287925829458 3632 3334705 SGTC_979 1426-2828 121 µM -0.683579981097844 0.249049103009738 no 2565 0.247120214689124 3717 747872 SGTC_1519 esterone 74 µM -0.683956952169415 0.248931020967021 no 2566 0.247001174607481 3625 698 A steroid. SGTC_2645 abamectin 100 µM -0.68456904023921 0.248739354596506 no 2567 0.246807954554255 3635 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_720 r052-1644 49.9 µM -0.684811308276658 0.248663513639203 no 2568 0.246731499285006 3635 1422863 YOR257W CDC31 SGTC_1123 mangostin 811.285 nM -0.685524044711165 0.248440466025479 no 2569 0.246506646527227 3629 5281650 An antioxidant. SGTC_1341 1486-1360 280 µM -0.685588582691078 0.248420274425111 no 2570 0.246486291628158 3654 3976547 SGTC_252 miconazole 1.30953 nM -0.685705091252255 0.24838382532377 no 2571 0.246449547794102 3609 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1621 st003705 32.4 µM -0.686383999676774 0.248171489044298 no 2572 0.246235495757372 3683 24207032 SGTC_1432 4049-0298 68.4 µM -0.687313020543571 0.247881084224095 no 2573 0.245942747745861 3658 741646 SGTC_547 1120-0019 610 nM -0.688582279316781 0.247484617014834 no 2574 0.245543087894859 3623 3676939 SGTC_190 3970-0790 3.722 µM -0.68880877635171 0.247413903770837 no 2575 0.245471805986561 3626 2832352 SGTC_2572 astragaloside iv 100 µM -0.689675656553011 0.247143360227688 no 2576 0.245199088932694 3664 45006101 An anti-inflammatory agent. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.689831403240365 0.247094770214377 no 2577 0.245150108916178 3655 616764 SGTC_455 paf C-16 10 µM -0.690036981246003 0.247030641599614 no 2578 0.245085465748208 3629 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_591 4299-0174 154 µM -0.690120726753636 0.247004520329511 no 2579 0.245059134942239 3637 5509088 SGTC_2703 st077852 53.4 µM -0.690716714989381 0.246818666843601 no 2580 0.244871791526177 3645 6281836 SGTC_2629 bisabolol 100 µM -0.691499759340094 0.246574595453686 no 2581 0.244625765951623 3659 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_573 3702-0553 84.7 µM -0.693776745764697 0.245865604271335 no 2582 0.243911114042303 3644 1222756 SGTC_1505 k297-0037 20.6 µM -0.694138607139472 0.245753031400304 no 2583 0.243797644547619 3668 4089396 SGTC_826 1683-5028 118 µM -0.694816842533893 0.245542111059976 no 2584 0.243585045875746 3696 722377 SGTC_2108 5365811 200 µM -0.695833171340862 0.245226231216194 no 2585 0.243266656458343 3700 780283 SGTC_1184 1269-1718 139 µM -0.699625175225504 0.244049589168005 no 2586 0.242080708086224 3693 5403821 SGTC_2166 5933061 31.504 µM -0.700808427682518 0.243683055506887 no 2587 0.241711288939704 3853 2877375 SGTC_2355 9061122 103.12 µM -0.702470643667153 0.243168656747821 no 2588 0.241192851527539 3678 5302957 SGTC_3256 9138902 49.47 µM -0.703066459053368 0.242984415386878 no 2589 0.24100716674745 3697 17228773 SGTC_1214 0358-0031 63.7 µM -0.703535849394374 0.24283932107885 no 2590 0.240860936866386 3733 4301366 SGTC_302 1094-0063 18.9 µM -0.703906082151983 0.242724910678625 no 2591 0.240745631756145 3638 5440289 SGTC_2418 pentamidine 31.67 µM -0.704137028462452 0.242653557760262 no 2592 0.240673721165425 3674 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_954 1189-0853 2.85 µM -0.704145188825097 0.242651036751328 no 2593 0.240671180457568 3668 2828194 SGTC_806 3966-4455 5.86 µM -0.704548441965129 0.242526476036598 no 2594 0.240545646820263 3651 714982 SGTC_401 neomycin 50 µM -0.704601684970353 0.242510032412685 no 2595 0.240529074814112 3668 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1475 4092-1048 11.7 µM -0.704986670380204 0.242391151098119 no 2596 0.240409265733091 3682 2881759 SGTC_3353 9151644 39.2805 µM -0.705007161618991 0.242384824404758 no 2597 0.240402889684518 3702 4909158 SGTC_1895 st058434 18.3 µM -0.706115309203344 0.242042815861357 no 2598 0.240058215985355 3691 5393175 SGTC_1565 sinapyl alcohol 95.1 µM -0.706258313334666 0.241998699446609 no 2599 0.240013756200014 3673 5280507 A phenol propionate derived from cinnamic acid. SGTC_276 colchicine 750 µM -0.706606962720807 0.241891160268526 no 2600 0.239905380410379 3714 2833 A microtubule depolymerizer. SGTC_1243 0416-0003 5.65 µM -0.706844020798845 0.2418180556871 no 2601 0.239831707425895 3703 2141977 SGTC_481 bay k-8644 50 µM -0.708457111522223 0.24132092510892 no 2602 0.239330718462125 3660 2303 A calcium channel antagonist. SGTC_1029 k015-0030 64.7 µM -0.70872220740781 0.241239279660578 no 2603 0.239248440491063 3742 2208316 SGTC_928 2764-0428 58.7 µM -0.708993219924961 0.241155827502093 no 2604 0.239164342149689 3722 662578 SGTC_155 k072-0202 43.6 µM -0.709987641964262 0.240849752265391 no 2605 0.238855899842878 3626 5857737 SGTC_70 0141-0289 43.283 µM -0.710239258200906 0.240772340295515 no 2606 0.238777889925397 3737 352408 SGTC_2685 mycophenolic acid 18.85 µM -0.710281933209299 0.24075921229319 no 2607 0.238764660548554 3668 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2160 5660466 132.927 µM -0.711449654631111 0.240400140374201 no 2608 0.238402819155013 3647 2859134 SGTC_499 genistein 192 µM -0.71176826607545 0.240302218692179 no 2609 0.23830414331583 3695 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3253 9135987 49.47 µM -0.712657810182859 0.240028942281041 no 2610 0.238028764727063 3687 4182430 SGTC_1274 0865-0114 173 µM -0.712708984736307 0.240013226127537 no 2611 0.238012927789061 3705 870624 SGTC_717 1532-0246 73.2 µM -0.712789381841427 0.239988536605727 no 2612 0.237988048543679 3702 9561992 SGTC_468 gf-109203x 121 µM -0.713353815451618 0.239815241054797 no 2613 0.23781342217133 3636 2396 A protein kinase C inhibitor. SGTC_3331 9141060 1.957 µM -0.714725803222731 0.239394290523963 no 2614 0.237389245138327 3696 4906567 YPR165W RHO1 SGTC_1776 st049249 45.9 µM -0.714963988722709 0.239321252060691 no 2615 0.237315647743058 3730 1822314 SGTC_1077 5-fluorocytosine 377 nM -0.714980859250005 0.239316079254517 no 2616 0.237310435361648 3711 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1233 0325-0408 14.2 µM -0.715540767204587 0.23914443609172 no 2617 0.23713747977303 3732 12874 SGTC_759 3486-0358 89.3 µM -0.716456282813592 0.23886392426097 no 2618 0.236854826229589 3717 875103 SGTC_1311 1190-0148 100 µM -0.717657630446649 0.238496107337414 no 2619 0.236484206951438 3758 1961333 SGTC_2790 5423970 71.43 µM -0.718268487634004 0.238309200013708 no 2620 0.236295878187836 3731 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3100 9120536 49.47 µM -0.719018471744287 0.238079833024757 no 2621 0.236064769236525 3587 16421196 SGTC_757 1066-0008 322 µM -0.719234484494815 0.238013792482331 no 2622 0.235998227627191 3737 6842497 SGTC_961 1252-1571 372 µM -0.720502064919447 0.23762646362072 no 2623 0.235607964400021 3704 6813498 SGTC_2073 5212005 126 µM -0.720945722743956 0.237490978846232 no 2624 0.235471454983591 3573 691789 SGTC_2979 9012552 45.46 µM -0.721414421984409 0.237347892964822 no 2625 0.23532728797659 3755 17100905 SGTC_3184 9108758 49.47 µM -0.72284404066387 0.236911747318319 no 2626 0.23488785327022 3715 902885 SGTC_438 sphingosine 6.67 µM -0.72312651407991 0.236825622964747 no 2627 0.234801080570468 3651 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1718 roemerine 11.9335 µM -0.723936805323931 0.236578665851628 no 2628 0.234552266436943 3623 235224 An aporphine alkaloid with mutagenic activity. SGTC_3028 9087778 49.47 µM -0.724244636734188 0.236484883459402 no 2629 0.234457779646355 3693 17217395 SGTC_1289 0976-0073 69.1 µM -0.730168560577422 0.234684121289449 no 2630 0.232643578737848 3757 3391136 SGTC_81 0411-0046 9.971 µM -0.730450945470716 0.234598471303029 no 2631 0.232557293691508 3636 12925265 SGTC_1124 fisetin 1.16336 µM -0.730988328233525 0.234435525836256 no 2632 0.23239314109071 3739 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2181 6316240 54.2555 µM -0.731456745922026 0.234293543090988 no 2633 0.232250107620848 3719 12779990 SGTC_1765 st044815 90.4 µM -0.731951722979425 0.234143561633137 no 2634 0.232099017372192 3746 645695 SGTC_1808 st050063 61.5 µM -0.732183178375273 0.234073447300025 no 2635 0.232028385091752 3700 4011993 SGTC_186 3455-3465 67.277 µM -0.733026743809018 0.233818006107311 no 2636 0.231771059053648 3680 755278 SGTC_3305 9127027 53.8275 µM -0.733874467407232 0.233561461481331 no 2637 0.231512624833337 3673 41905295 SGTC_2449 5812982 45.77 µM -0.734043780280517 0.233510241427506 no 2638 0.231461027923023 3692 776185 SGTC_3071 9117417 49.47 µM -0.735993262445901 0.232920938614815 no 2639 0.230867399044366 3662 45595590 YGL055W OLE1 SGTC_1451 4152-0210 104 µM -0.736246543640879 0.232844435725034 no 2640 0.23079033587061 3720 659563 SGTC_1835 st008666 49.2 µM -0.736310348741575 0.232825165771103 no 2641 0.230770924837393 3666 690455 SGTC_374 0880-0231 82.3 µM -0.73860462917752 0.232132852878437 no 2642 0.230073556222272 3692 6833587 SGTC_2752 diclazuril 33.15 µM -0.740055704909269 0.231695574278454 no 2643 0.229633097240598 3773 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1094 duloxetine 25.4 µM -0.7400842209839 0.231686985620894 no 2644 0.229624446217059 3731 60834 A selective serotonin reuptake inhibitor. SGTC_2044 5102272 200 µM -0.740296950681917 0.231622919899946 no 2645 0.22955991540922 3733 592666 SGTC_2245 6637752 200 µM -0.740975578008724 0.231418610352005 no 2646 0.229354124110748 3771 681890 SGTC_746 1095-0025 46.6 µM -0.743798037691309 0.230569951336109 no 2647 0.228499333753047 3736 6749286 SGTC_364 0083-0097 67.7 µM -0.744352038601694 0.230403578408763 no 2648 0.228331763286277 3806 5207356 SGTC_2846 9008642 19.48 µM -0.745670098356601 0.230008019631161 no 2649 0.227933363200862 3789 2992898 SGTC_3288 9119690 36.221 µM -0.747040243802704 0.22959723275899 no 2650 0.227519634441008 3747 17595618 YKL019W RAM2 SGTC_1296 1068-0102 11.9 µM -0.747374040655586 0.229497218553308 no 2651 0.227418905335373 3752 767053 SGTC_23 0213-0011 39.996 µM -0.748899262711397 0.229040533181251 no 2652 0.226958962372459 3767 627608 SGTC_448 monastrol 171 µM -0.749180627279583 0.228956342113189 no 2653 0.226874171977459 3672 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2600 tangeritin 87.95 µM -0.749420007842648 0.228884727346444 no 2654 0.226802047708976 3710 68077 A bioactive flavone. SGTC_12 0849-0099 9.267 µM -0.750919673541767 0.228436363039702 no 2655 0.226350499778344 3679 6071388 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.752329189332081 0.228015401668988 no 2656 0.225926559199539 3793 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1266 0828-0227 32.9 µM -0.75267305491937 0.227912770145866 no 2657 0.225823202785901 3790 3913820 SGTC_3063 1327-0034 4 µM -0.753095601281424 0.227786690836329 no 2658 0.225696233751734 3655 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_6 0844-0013 19.835 µM -0.753999523616241 0.227517110491702 no 2659 0.225424753898415 3856 1584900 SGTC_2319 6033012 152.6 µM -0.755126633927738 0.227181219749278 no 2660 0.225086501920685 3733 847246 SGTC_586 0957-0265 8.15 µM -0.756425071920175 0.226794618250628 no 2661 0.224697190284777 3639 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2556 citropten 84.59 µM -0.758359407200789 0.226219371410632 no 2662 0.224117925944133 3802 2775 A potential DNA crosslinker. SGTC_2724 maprotiline 69.64 µM -0.760105236806785 0.225700892318894 no 2663 0.223595841317784 3720 4011 A tricyclic antidepressant. SGTC_2641 levomentholum 100 µM -0.761968485174683 0.225148284402174 no 2664 0.223039406779964 3745 16666 SGTC_1878 temozolomide 1 mM -0.764554447516036 0.224382603409025 no 2665 0.222268451542435 3700 5394 DNA alkylating agent. SGTC_2141 5621638 7.665 µM -0.765098317847434 0.224221756441441 no 2666 0.222106500736687 3815 2856238 SGTC_1717 st033143 58.0435 µM -0.765159162277813 0.224203766074133 no 2667 0.222088386996852 3760 674616 SGTC_1445 4239-0156 97.7 µM -0.766190212857275 0.223899031625382 no 2668 0.221781565502659 3872 4008346 SGTC_361 000s-0510 1.45 µM -0.766915472664014 0.223684816939023 no 2669 0.221565886808717 3791 660 SGTC_1961 st076550 68.7 µM -0.768191499819257 0.223308209144663 no 2670 0.22118671136619 3773 1579337 SGTC_154 3389-1638 511.116 µM -0.768670852605923 0.223166825831699 no 2671 0.22104436617102 3716 5238686 SGTC_1130 3454-2858 15.9 µM -0.768802914575303 0.223127883603144 no 2672 0.221005159200678 3824 715628 YIL048W NEO1 SGTC_1285 0929-0069 65.5 µM -0.769060945781424 0.223051806927589 no 2673 0.220928565576302 3792 1206237 SGTC_2101 5377231 179.231 µM -0.769290774806845 0.222984057686495 no 2674 0.220860356244964 3828 2844213 SGTC_674 0498-0004 451 µM -0.769309737336205 0.222978468415661 no 2675 0.220854729028448 3797 4231473 SGTC_2528 xanthyletin 44.79 µM -0.769504018492566 0.222921207972882 no 2676 0.220797079944093 3842 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2495 cafestol 54.53 µM -0.771473964351444 0.222341079530625 no 2677 0.220213024394956 3771 16667697 An anti-infammatory. SGTC_1539 benzyladenosine 56 µM -0.771629072131212 0.222295438517226 no 2678 0.220167075223263 3765 92208 A nucleotide analog. SGTC_3307 9126885 69.2785 µM -0.771637057398405 0.222293088968766 no 2679 0.220164709814333 3782 24824909 SGTC_124 0136-0217 7.121 µM -0.772932718697034 0.221912047220241 no 2680 0.21978109998618 3856 3976905 SGTC_953 1188-0045 9.7 µM -0.77385396693359 0.221641343860392 no 2681 0.219508577167044 3807 6144426 SGTC_1476 4112-3294 3.34 µM -0.77538533937801 0.221191776917505 no 2682 0.219055997748205 3836 704369 SGTC_2447 5741742 33.78 µM -0.77552070932025 0.221152061303528 no 2683 0.219016016557405 3842 1776504 SGTC_3062 9077494 49.47 µM -0.775943744254271 0.221027975176168 no 2684 0.21889110124812 3781 16459633 SGTC_2697 mebhydrolin 72.4 µM -0.77695902637515 0.220730331602512 no 2685 0.218591472297668 3799 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2990 9074105 71.4286 µM -0.777877040625661 0.220461401142636 no 2686 0.218320752327174 3748 6502001 SGTC_853 0419-0306 21 µM -0.778811593813312 0.220187818619654 no 2687 0.218045353575013 3807 762713 SGTC_1371 2421-0008 32.7 µM -0.778834986718386 0.220180973043706 no 2688 0.218038462608296 3791 2827552 SGTC_2145 5634607 200 µM -0.778933644957833 0.220152103561501 no 2689 0.21800940173152 3784 308662 SGTC_44 0929-0055 61.211 µM -0.781603542123012 0.219371660079326 no 2690 0.217223802289081 3767 1379590 SGTC_2775 cyproheptadine 69.59 µM -0.781844271318753 0.219301370221038 no 2691 0.217153049782453 3795 2913 A selective serotonin reuptake inhibitor. SGTC_2049 5262831 67.185 µM -0.78239556200871 0.219140449135339 no 2692 0.216991070584729 3857 763417 SGTC_589 1227-0070 34.1 µM -0.783620556543909 0.218783117849809 no 2693 0.216631395063868 3839 2841384 SGTC_621 3584-0052 32.1 µM -0.783996446917909 0.218673537775602 no 2694 0.216521097579017 3792 2273927 SGTC_269 exalamide 29 µM -0.784830256111606 0.218430577376919 no 2695 0.216276549020073 3765 3316 A derivative of salicylamide. SGTC_378 3970-0959 8.33 µM -0.785408699653037 0.218262118355373 no 2696 0.216106990840324 3849 6615653 SGTC_1039 k821-0043 94 µM -0.785950153882636 0.218104499512042 no 2697 0.215948345060211 3769 15992768 SGTC_983 1491-0821 12.2 µM -0.787968253272241 0.21751760341809 no 2698 0.215357637862446 3813 46495113 SGTC_2398 5228213 48.84 µM -0.788801324669452 0.217275598786147 no 2699 0.215114067584289 3802 80771 YMR134W ERG29 SGTC_26 0302-0163 425.158 µM -0.789034696750178 0.21720783282038 no 2700 0.2150458638209 3852 3100915 SGTC_768 0384-0033 77.3 µM -0.789359821445878 0.217113444328866 no 2701 0.214950865986451 3794 3965305 YMR134W ERG29 SGTC_1115 galangin 695.678 nM -0.793465343005422 0.215923591563417 no 2702 0.213753376756782 3848 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2625 euphol 100 µM -0.794579000212402 0.215601486653195 no 2703 0.213429218934609 3822 6708538 A triterpene alcohol. SGTC_1367 1812-0510 76.9 µM -0.795741295646709 0.21526561136469 no 2704 0.213091209513852 3868 1142582 YDR527W RBA50 SGTC_2875 9039966 71.43 µM -0.796462595734648 0.215057325856931 no 2705 0.212881603935511 3882 6463691 SGTC_1684 st024538 14.6195 µM -0.796742093224525 0.214976648506648 no 2706 0.212800415961751 3809 6732859 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.797724414277533 0.214693239608607 no 2707 0.212515216382144 3829 688669 SGTC_2423 st077119 87.2 µM -0.798534253924684 0.21445975659596 no 2708 0.212280261735741 3767 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2251 lansoprazole 556 µM -0.798683438791637 0.214416761558532 no 2709 0.212236996057239 3754 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1764 st044502 93.5 µM -0.798738434253932 0.214400913146061 no 2710 0.212221047911549 3880 8407 SGTC_1221 2958-7315 257 µM -0.799451018322398 0.214195624605437 no 2711 0.212014468858139 3846 4562705 SGTC_1418 3966-3099 2.4 µM -0.799455107857304 0.214194446780348 no 2712 0.21201328363612 3801 740335 SGTC_680 0417-1641 114 µM -0.800001555292949 0.214037098597735 no 2713 0.211854948028448 3800 2835990 SGTC_3145 9085516 49.47 µM -0.800753079685798 0.213820808939055 no 2714 0.211637303484275 3895 25236195 SGTC_574 1315-0397 40 µM -0.80083273342887 0.213797891954753 no 2715 0.211614243107436 3842 6794277 SGTC_329 k048-0121 21.3 µM -0.801855085877901 0.2135038804477 no 2716 0.211318394756885 3842 6832902 SGTC_642 0335-0876 158 µM -0.801882301931962 0.213496056785809 no 2717 0.21131052228748 3849 6812350 SGTC_341 1486-1430 230 µM -0.80370129711536 0.2129735382707 no 2718 0.210784752415289 3805 2054753 YPL210C SRP72 SGTC_889 0919-1524 82.7 µM -0.804753839937725 0.212671529440897 no 2719 0.210480871861033 3882 3905452 SGTC_1125 tnp00248 1.32998 µM -0.804875529277975 0.212636628939071 no 2720 0.210445755416216 3943 24207736 SGTC_2415 st077333 57.7 µM -0.805687408128088 0.212403867701129 no 2721 0.210211555881402 3824 2766255 SGTC_1459 k035-0031 35.7 µM -0.807180672876009 0.211976145779953 no 2722 0.209781199520641 3688 3877128 YMR208W ERG12 SGTC_2104 5389443 200 µM -0.812312597024593 0.210510033718988 no 2723 0.208306142054525 3906 2244536 SGTC_1206 3978-0017 132 µM -0.812819815984452 0.210365452918892 no 2724 0.208160686244833 3942 3873677 SGTC_209 4077-0173 175.592 µM -0.813716876676872 0.210109892021737 no 2725 0.20790358183272 3808 15993494 SGTC_2616 abietic acid 100 µM -0.817225325770633 0.209112133704502 no 2726 0.206899836011891 3853 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2927 9011802 47.9 µM -0.81894606039919 0.208623800104808 no 2727 0.206408594485664 3879 43912568 SGTC_1753 st043925 64 µM -0.821392391388669 0.207930705310123 no 2728 0.205711398029003 3915 670181 SGTC_3089 9117425 49.47 µM -0.822385029319537 0.207649859217998 no 2729 0.205428898494321 3834 9401657 SGTC_301 4119-0100 24.5 µM -0.822549397869764 0.207603376220486 no 2730 0.205382142312815 3884 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1744 st037937 38.9 µM -0.822828793402254 0.207524378001885 no 2731 0.205302680127766 3934 1016152 SGTC_1514 1189-1591 158 µM -0.823075806547168 0.207454550601589 no 2732 0.205232442949522 3904 767698 YMR146C TIF34 SGTC_2497 7-hydroxyflavone 100 µM -0.824780075123333 0.206973154656392 no 2733 0.204748230327392 3874 5281894 SGTC_2459 5811157 9.22 µM -0.825766163440389 0.206694921524301 no 2734 0.204468375914269 3840 2870684 YBR192W RIM2 SGTC_3302 9125395 16.351 µM -0.826322692257277 0.20653799004541 no 2735 0.204310532149056 3826 17599668 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.828323229540248 0.205974456346207 no 2736 0.203743735362522 3877 641818 YHR062C RPP1 SGTC_3018 9082602 49.47 µM -0.829205773090742 0.205726141797985 no 2737 0.203493989389365 3869 17332089 SGTC_2250 alverine citrate 130 µM -0.829348429027497 0.20568602047085 no 2738 0.203453637149431 3784 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_965 1291-5240 308 µM -0.83052522697434 0.205355228655054 no 2739 0.203120945426516 3864 2834598 SGTC_1255 0566-0045 221 µM -0.831013999747367 0.205217930084783 no 2740 0.202982860335995 3935 2788469 SGTC_780 0109-0199 192 µM -0.831895551165733 0.204970436086199 no 2741 0.202733951610333 3946 610414 SGTC_1155 4088-0394 48.2 µM -0.832782976804426 0.204721472218727 no 2742 0.202483568581181 3856 2326248 SGTC_2267 7931562 200 µM -0.83361951248155 0.204486950114458 no 2743 0.202247713283669 3785 934880 SGTC_2789 5281112 71.43 µM -0.834512819179232 0.204236688921161 no 2744 0.201996033333694 3921 765948 SGTC_2731 amoxapine 43.43 µM -0.836175458974757 0.20377138384917 no 2745 0.201528101152625 3956 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_597 k018-0003 82.8 µM -0.83874509654409 0.203053491449636 no 2746 0.200806183072119 3964 6786234 SGTC_1134 3477-0009 42.5 µM -0.840311691267426 0.20261656605545 no 2747 0.200366823982189 3987 3973534 SGTC_556 4058-0063 51.5 µM -0.842729559222243 0.201943323383906 no 2748 0.199689855758561 3945 6615692 SGTC_1548 st061468 90.8 µM -0.845782311452786 0.201095215892564 no 2749 0.198837097465385 3884 390799 SGTC_1590 st077108 57.8 µM -0.846344180686465 0.200939351976023 no 2750 0.198680383996746 3888 5489485 SGTC_2386 9075165 157.42 µM -0.847051244973514 0.20074331362056 no 2751 0.198483279398469 3860 16452277 SGTC_1555 citronellol 128 µM -0.847067026554879 0.200738939380543 no 2752 0.198478881396232 3815 8842 A terpine precursor. SGTC_2074 5212007 75.395 µM -0.84944856005647 0.200079496757009 no 2753 0.197815871016254 3756 758611 SGTC_3349 9149703 23.001 µM -0.849904459620867 0.199953407602076 no 2754 0.197689102982506 3885 4910494 SGTC_1314 1222-0010 41.1 µM -0.85048593156298 0.199792657967338 no 2755 0.197527489391146 3909 3526027 SGTC_2381 9035592 200 µM -0.850595975418198 0.19976224476894 no 2756 0.197496912929674 3919 4749657 SGTC_619 1652-1634 108 µM -0.851519651866728 0.19950707494757 no 2757 0.197240375750461 3863 5400454 SGTC_805 3852-0218 479 µM -0.851538540574626 0.199501858903909 no 2758 0.197235131801443 3842 6615355 SGTC_1774 st048371 48.465 µM -0.852091313847309 0.199349249054752 no 2759 0.197081706310142 3871 4242727 SGTC_1694 st024011 44.9 µM -0.852367685085402 0.199272974745785 no 2760 0.197005024928713 3915 2787533 SGTC_1975 st070967 30.8 µM -0.852470667585616 0.199244557618338 no 2761 0.196976456240123 3858 261391 SGTC_2253 7938677 135.83 µM -0.854967042817528 0.198556451421633 no 2762 0.196284696633487 3996 2301972 SGTC_2036 5160441 105 µM -0.858412439258212 0.197609112893867 no 2763 0.195332380614014 3895 134534 YIL048W NEO1 SGTC_2876 9059903 25.97 µM -0.860053995869076 0.197158716738379 no 2764 0.194879639350561 3845 6916095 SGTC_307 1501-1223 22.3 µM -0.860754535283615 0.196966698021133 no 2765 0.19468662503851 3921 2830329 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.862411187360564 0.196513058261979 no 2766 0.19423064321519 3831 1241132 A phosphatase inhibitor. SGTC_116 0155-0182 31.788 µM -0.864575528894587 0.195921353040627 no 2767 0.193635904318447 3856 771486 SGTC_2353 9059630 146.67 µM -0.865020850487693 0.195799741642409 no 2768 0.193513672399816 3978 4779114 SGTC_1384 3089-0840 101 µM -0.865058621984101 0.195789428857724 no 2769 0.193503307041148 3891 1069836 SGTC_1554 st069299 38.7 µM -0.865821945021467 0.195581088756901 no 2770 0.193293906404627 3877 24207999 SGTC_2328 6201408 200 µM -0.866645270943178 0.195356522535584 no 2771 0.19306820040475 3942 2890418 SGTC_1820 st053765 18.6 µM -0.867132952587318 0.195223578854978 no 2772 0.192934583615307 3984 3690829 SGTC_3347 9188721 44.724 µM -0.867170305780141 0.195213398514339 no 2773 0.192924351780856 3972 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_899 1083-0020 478 µM -0.867665653507586 0.195078425607105 no 2774 0.19278869683699 4004 767123 SGTC_2624 nerol 100 µM -0.867837921716547 0.195031499069192 no 2775 0.192741533468463 3838 637566 A natural product oil. SGTC_1673 st016611 27.3 µM -0.869199350368648 0.194660882023359 no 2776 0.192369051345697 3974 5226799 SGTC_2274 7947094 46.08 µM -0.869827427789785 0.194490047205124 no 2777 0.192197360038833 3880 2971028 SGTC_2081 5214970 32.255 µM -0.87048722038238 0.194310684289664 no 2778 0.192017100064624 3840 2063512 SGTC_1655 st012546 55.1 µM -0.871167099278673 0.194125966368999 no 2779 0.19183146064656 3904 720985 YLR208W SEC13 SGTC_2305 7443522 69.23 µM -0.878003701082376 0.19227446522285 no 2780 0.189970855106902 3855 5415886 SGTC_1063 disulfiram 1.84 µM -0.878664032412756 0.1920962068644 no 2781 0.189791732953079 3928 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1313 1220-0047 237 µM -0.879188065403366 0.191954814629388 no 2782 0.189649657168993 3931 3528706 SGTC_36 0335-0881 14.2 µM -0.881345815815699 0.191373291492922 no 2783 0.189065337645808 3863 23828853 SGTC_2425 5628681 7.85 µM -0.881703510591234 0.191276995620157 no 2784 0.188968581036762 4010 5714958 SGTC_738 1315-0003 72.4 µM -0.881741019453538 0.191266899489767 no 2785 0.188958436638846 3988 6251474 SGTC_1411 3909-8223 150 µM -0.884023105319056 0.190653253011891 no 2786 0.188341870123958 3962 X1411 SGTC_41 0478-0632 82.643 µM -0.885536535411654 0.190246963135811 no 2787 0.187933661768593 3859 3750424 SGTC_3077 9117319 49.47 µM -0.888688839945282 0.189402416477902 no 2788 0.187085165250909 3913 17154678 SGTC_2045 5106652 78.05 µM -0.888787410172368 0.189376045388116 no 2789 0.187058671656093 3917 673349 SGTC_195 4234-0266 16.654 µM -0.891424548896393 0.188671354956695 no 2790 0.186350726327695 3955 2303354 SGTC_2455 5377712 9.75 µM -0.891815964359463 0.188566899711353 no 2791 0.186245791687109 3968 2243908 SGTC_2557 derrustone 83.84 µM -0.892685665867973 0.188334934132974 no 2792 0.186012764352887 3945 629853 An antioxidant. SGTC_254 nsc-64875 3.808 µM -0.892881576601381 0.188282705397072 no 2793 0.185960297096718 3994 56993 SGTC_1826 st055655 41.6 µM -0.893213945369881 0.188194118133679 no 2794 0.185871305725258 3998 676168 SGTC_1927 st060202 13.8 µM -0.893334274491832 0.188162052787503 no 2795 0.18583909424817 3850 688887 SGTC_3064 1327-0027 10 µM -0.893525706361718 0.188111046905503 no 2796 0.185787856072791 3859 16000455 YPR107C YTH1 SGTC_356 1634-0012 32.5 µM -0.893867359659258 0.188020036626446 no 2797 0.185696431783324 3959 735457 SGTC_2383 9036125 200 µM -0.894411800943486 0.187875063464146 no 2798 0.185550800383295 3854 79580 SGTC_260 nsc-65238 3.989 µM -0.896198844611216 0.187399696957502 no 2799 0.18507328633448 3947 3246252 SGTC_2015 5119600 184 µM -0.898448396035934 0.186802358124813 no 2800 0.184473272510778 4016 2828786 SGTC_1648 st011736 69.8 µM -0.899852344965901 0.186430155856453 no 2801 0.184099416783916 3964 2855514 SGTC_1365 1672-3266 55.4 µM -0.899998691981456 0.186391384112026 no 2802 0.184060473391405 4005 6415873 SGTC_1588 farnesol 29.9 µM -0.900986400324848 0.186129840976905 no 2803 0.183797775281591 3968 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3027 9089541 49.47 µM -0.905531438795848 0.184929258169215 no 2804 0.182591956090625 3999 9943819 SGTC_693 4161-2696 114 µM -0.907000792381468 0.184542156532196 no 2805 0.182203189103246 4011 805759 SGTC_2232 chlorophetanol 41.5365 µM -0.907410086390426 0.184434417707216 no 2806 0.18209498877966 4042 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_32 0928-0142 34.1 µM -0.907804223582999 0.18433070561369 no 2807 0.181990833261934 3938 2244242 SGTC_3333 9141820 12.094 µM -0.909285127821165 0.183941349262898 no 2808 0.181599819448085 3973 1939433 SGTC_530 4358-1714 28 µM -0.909748695420779 0.183819574331758 no 2809 0.181477528481239 4007 1564641 SGTC_3207 9114163 49.47 µM -0.91052467149548 0.183615844988474 no 2810 0.181272938321072 4022 849233 SGTC_3141 9094609 49.47 µM -0.913249689003822 0.182901518060158 no 2811 0.180555618043472 3938 25236309 YDL196W YDL196W SGTC_370 0180-0345 38.7 µM -0.91406134700588 0.182689088430659 no 2812 0.18034230573449 3865 3989527 SGTC_1884 5633444 25 µM -0.915625384887502 0.182280178264177 no 2813 0.179931706188088 3999 5724239 SGTC_3128 9127691 49.47 µM -0.916181050208798 0.182135040048207 no 2814 0.179785971423934 4055 41316314 SGTC_898 1000-0849 28.3 µM -0.916726749779835 0.181992575187065 no 2815 0.179642922574335 3982 6751807 SGTC_1269 0831-0796 3.05 µM -0.917905793465576 0.181685002246956 no 2816 0.179334094156808 4031 927758 SGTC_572 0960-0087 17.7 µM -0.918756826155768 0.181463198598986 no 2817 0.17911138965105 3978 6796365 SGTC_1351 1496-0003 46.5 µM -0.919359539574151 0.181306216688515 no 2818 0.178953772449757 4026 3891978 SGTC_601 0986-0029 62.9 µM -0.920732992174327 0.180948806918263 no 2819 0.178594923379224 3954 24747981 SGTC_1606 st000094 49.2 µM -0.92252004397348 0.180484428865185 no 2820 0.178128690043734 4012 1242210 SGTC_3167 9103034 49.47 µM -0.923020725133741 0.180354457505389 no 2821 0.177998202422507 4043 5127859 SGTC_2682 pyrogallin 40.03 µM -0.923380746174976 0.180261036281806 no 2822 0.177904410930865 4003 822798 An ATP competetive kinase inhibitor. SGTC_876 0720-0963 56.8 µM -0.923729757008061 0.180170501073258 no 2823 0.177813517541275 4044 765861 SGTC_1213 1315-0166 115 µM -0.925043618311967 0.17982993470857 no 2824 0.17747160953169 4113 768401 SGTC_2100 5377183 190 µM -0.926340825424817 0.179494082272952 no 2825 0.177134442898181 4027 2844202 SGTC_285 1486-1325 46 µM -0.927922872043425 0.179085017698111 no 2826 0.176723789586055 4046 22310230 SGTC_1322 1348-1070 12 µM -0.929710137738033 0.178623596462691 no 2827 0.176260592060268 3964 6758089 SGTC_1066 ketoconazole 628 nM -0.92991968597384 0.178569546137578 no 2828 0.176206334760746 4067 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1344 1488-0097 29.1 µM -0.930521044704905 0.178414490439523 no 2829 0.176050686589531 4035 747966 SGTC_1494 4358-1428 177 µM -0.931167252671543 0.178247965290928 no 2830 0.17588352725916 4041 1564571 SGTC_3332 9141069 11.198 µM -0.931492089721234 0.178164293120525 no 2831 0.17579953726631 3939 17332883 SGTC_1978 st071761 42 µM -0.931494699576324 0.178163620969154 no 2832 0.175798862564067 4029 5147680 SGTC_2465 5809242 33.21 µM -0.932430758020043 0.177922648244799 no 2833 0.175556977635214 4031 2731748 SGTC_3036 9090181 49.47 µM -0.936249357355006 0.176941744120182 no 2834 0.174572407941989 4031 25236586 SGTC_603 3794-0023 45.9 µM -0.937514450054328 0.176617528030276 no 2835 0.174246997173777 4029 3802260 SGTC_1924 st058459 75.1 µM -0.939084053440955 0.176215794937259 no 2836 0.173843795463684 3985 688683 SGTC_2283 7944793 200 µM -0.939869538977906 0.17601497065925 no 2837 0.173642241897448 4054 2970533 SGTC_2304 7443016 91.4 µM -0.942263957665483 0.175403686675444 no 2838 0.173028758078832 3936 939854 SGTC_1488 4013-0813 75.9 µM -0.942315083482791 0.175390649183552 no 2839 0.173015673997874 3956 2910057 SGTC_1091 telmisartan 47.6 µM -0.944495362678185 0.174835232377455 no 2840 0.172458285234187 4076 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_104 0074-0074 590.992 µM -0.944631012570648 0.174800713074728 no 2841 0.172423644201149 3818 3943124 SGTC_1973 st070275 50.2 µM -0.946785999273884 0.174252906422281 no 2842 0.171873918741354 3966 17118334 SGTC_753 1322-0200 289 µM -0.947034146177263 0.174189896556828 no 2843 0.171810689741981 4115 5403907 SGTC_475 α-linolenic acid 10 µM -0.947678192528872 0.17402642683216 no 2844 0.17164665302164 4031 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_34 0469-0683 81.75 µM -0.951296302193516 0.173109903944723 no 2845 0.170726991792555 3994 3690923 SGTC_2853 9015042 58.44 µM -0.951896699133836 0.172958112116962 no 2846 0.170574686879412 3940 6457456 SGTC_902 1120-0002 2.07 µM -0.952706696687297 0.17275346366928 no 2847 0.170369349695077 4015 3280475 SGTC_3341 9147222 25.867 µM -0.953050365911481 0.172666681206414 no 2848 0.170282276215431 4045 1939759 SGTC_677 0929-0063 136 µM -0.953108040592643 0.17265212006919 no 2849 0.170267666309913 4004 1539583 SGTC_2971 9092186 9.93 µM -0.955132532480422 0.172141492336943 no 2850 0.169755339501378 4061 25236400 SGTC_1510 1123-0200 71.5 µM -0.955354918705636 0.172085459753892 no 2851 0.169699121793029 4108 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_257 daunorubicin 18.5 µM -0.956264656219404 0.171856362915038 no 2852 0.169469270763724 4058 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3239 9133757 49.47 µM -0.956346617921778 0.171835732280447 no 2853 0.169448572427426 4045 17036923 SGTC_688 0527-0193 473 µM -0.956819122584694 0.171716828660241 no 2854 0.169329279303851 4064 4007154 SGTC_2553 4-methylesculetin 85.09 µM -0.957474985798868 0.171551870832825 no 2855 0.169163783063799 4069 5319502 SGTC_2093 5331342 194.4 µM -0.959281428463531 0.171098051557769 no 2856 0.168708494295388 4122 33839 SGTC_1473 k844-0725 134 µM -0.962133427273891 0.170383129514741 no 2857 0.167991292371581 4098 54682906 SGTC_1692 fluoroquinolonic acid 71 µM -0.963498150653195 0.170041706627498 no 2858 0.167648795893748 4093 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1291 0993-0025 5.79 µM -0.964056174390023 0.169902228121981 no 2859 0.167508881640668 4054 4353356 SGTC_779 1360-0071 233 µM -0.966524431019517 0.169286165368131 no 2860 0.166890913979656 4110 7566 SGTC_1108 betulinic acid 729.144 nM -0.966840036918737 0.169207495467037 no 2861 0.166812003149982 4054 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2071 5230951 39.92 µM -0.966845129707892 0.169206226199014 no 2862 0.166810729999116 4078 1799272 SGTC_2809 7964133 12.99 µM -0.968535356559993 0.168785311249451 no 2863 0.166388535001563 4067 1253665 SGTC_1534 6-azauridine 81.6 µM -0.969197631250063 0.168620569483887 no 2864 0.166223296361285 4073 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3344 9148862 3.898 µM -0.970326161581573 0.16834008417742 no 2865 0.165941970437202 4105 4905352 SGTC_2787 5284540 71.43 µM -0.971155146802492 0.168134239197345 no 2866 0.165735512833232 4115 736958 SGTC_2869 9037858 32.47 µM -0.972503885484436 0.167799680703087 no 2867 0.165399966421323 4009 27187042 SGTC_2075 5212009 200 µM -0.97326000857876 0.167612309837916 no 2868 0.165212046483366 3959 780898 SGTC_948 3448-0295 75.3 µM -0.974543459105124 0.167294573390411 no 2869 0.164893385871635 4038 678569 SGTC_2761 levamisole 97.89 µM -0.974597444749459 0.16728121698915 no 2870 0.164879990813414 4020 26879 An alkaline phosphatase inhibitor. SGTC_1840 st055363 71 µM -0.975938760142743 0.166949587483323 no 2871 0.164547406442325 4111 676033 SGTC_220 paclitaxel 373.376 µM -0.976481406056184 0.166815543176673 no 2872 0.164412978888969 4026 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_554 4483-2211 187 µM -0.977956310345314 0.166451563487167 no 2873 0.164047966428145 4110 747107 SGTC_1777 st045864 34.765 µM -0.978525249061374 0.166311296849724 no 2874 0.163907304874197 4037 4691462 SGTC_2826 7992541 19.48 µM -0.978799430899635 0.166243727090123 no 2875 0.163839545486878 4082 2985066 SGTC_1079 idarubicin 2.36 µM -0.980316405375336 0.165870202246144 no 2876 0.163464979585498 4074 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_4 0960-0234 25.671 µM -0.982573933312178 0.165315335962644 no 2877 0.162908589406393 4073 6821112 SGTC_2397 5161689 200 µM -0.985135623130623 0.164687167715139 no 2878 0.16227872866423 4134 2259942 SGTC_508 roscovitine 141 µM -0.985606012686811 0.164571988778998 no 2879 0.162163243180913 4141 160355 A CDKinase inhibitor. SGTC_345 1362-0200 395 µM -0.98758289509156 0.164088502943945 no 2880 0.161678483388937 4062 1419823 SGTC_2674 ligustilide 100 µM -0.988910136310338 0.163764417238655 no 2881 0.161353555371652 4124 5319022 A signalling regulator. SGTC_397 arbidol 50 µM -0.991749336537437 0.163072537454553 no 2882 0.160659908744377 4124 131410 A RNA synthesis inhibitor. SGTC_2198 6589944 200 µM -0.992011082808633 0.163008848750701 no 2883 0.160596059554432 4079 5290268 SGTC_1217 1183-1422 255 µM -0.992436396481502 0.162905394939565 no 2884 0.160492345831194 4107 2849664 SGTC_2009 4012297 12.05 µM -0.992656663563899 0.162851833691821 no 2885 0.160438650396625 4092 45595307 SGTC_1788 fluconazole 20 µM -0.993694664561012 0.162599582320879 no 2886 0.160185770529951 4129 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_986 1493-0483 84 µM -0.994590864635062 0.162381995511887 no 2887 0.159967646197364 4022 40079 SGTC_657 3534-0529 86.7 µM -0.99658260449833 0.161899103503584 no 2888 0.159483576532898 4146 1049549 SGTC_2924 9010168 62.78 µM -0.997154347885412 0.161760658851583 no 2889 0.159344798141549 4175 2993929 SGTC_691 1548-0686 185 µM -0.998733037898831 0.161378788115468 no 2890 0.158962015873816 4079 46495133 SGTC_550 4123-0385 25.7 µM -0.998978257735467 0.161319524467326 no 2891 0.158902611951003 4116 5731123 SGTC_2595 hexamethylquercetagetin 100 µM -0.999952263667816 0.161084271197218 no 2892 0.158666805002038 4070 386331 SGTC_917 harmaline 728.087 nM -1.00012975503843 0.161041425538768 no 2893 0.158623859047753 4067 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2471 5466956 24.79 µM -1.00237317887097 0.160500513767389 no 2894 0.158081695506888 4054 724419 SGTC_463 ikarugamyin 104 µM -1.00383971807331 0.160147558908458 no 2895 0.15772793830274 4175 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1559 coumarin 343 70.1 µM -1.00475730612474 0.159926979463853 no 2896 0.157506863247445 4126 108770 A hepatotoxic, DNA x-linker. SGTC_848 0368-0089 85.6 µM -1.0050660184742 0.15985281264356 no 2897 0.157432530791614 4093 762535 SGTC_3304 9125678 46.087 µM -1.00723469334396 0.159332432082554 no 2898 0.156911002355356 4028 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2929 9013348 24.6 µM -1.00783985341137 0.159187420141616 no 2899 0.156765675005128 4096 2995952 SGTC_2563 tomatine 8.54 µM -1.00926992869932 0.158845080886183 no 2900 0.156422598882327 3998 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3280 9140961 49.47 µM -1.00967476159245 0.158748257470618 no 2901 0.156325569035394 4131 4901226 SGTC_213 1246-0773 967 nM -1.01000644534582 0.1586689578917 no 2902 0.156246101036614 4098 6251622 SGTC_2064 5220758 200 µM -1.01075370899527 0.158490395873646 no 2903 0.156067161925901 4173 788518 SGTC_1726 st035556 14.5795 µM -1.01077197542982 0.158486032677673 no 2904 0.15606278955281 4199 5919439 SGTC_328 k915-0120 63.5 µM -1.01251622071205 0.158069757998993 no 2905 0.155645647500319 4088 6624543 SGTC_2437 5741531 144.16 µM -1.0131150933849 0.157926999083003 no 2906 0.155502594856814 4135 2262990 SGTC_2041 5107442 45.335 µM -1.0141031464061 0.157691652699157 no 2907 0.155266768418064 4154 793005 SGTC_2732 terfenadine 20 µM -1.0143781593812 0.157626187801559 no 2908 0.155201170910905 4143 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_281 1672-3440 14.9 µM -1.01481285621985 0.157522747709712 no 2909 0.155097522105836 4143 6833000 SGTC_1065 prochlorperazine maleate 2.48 µM -1.01488803505386 0.157504862743424 no 2910 0.155079601154716 4141 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1380 2291-0730 164 µM -1.01706102587411 0.156988487235095 no 2911 0.154562199687424 4142 2999191 SGTC_2666 tannic acid 100 µM -1.01747986502169 0.156889085162235 no 2912 0.154462603006729 4112 16134267 A thiamine antagonist. SGTC_2516 gossypol 71.55 µM -1.02227368287163 0.155754330027969 no 2913 0.153325692697349 4159 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_119 0121-0043 24.815 µM -1.02231621704853 0.1557442859535 no 2914 0.153315630094138 4115 1092378 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.02434447314483 0.155265826776749 no 2915 0.152836299462013 4162 61125 An anti-inflammatory. SGTC_648 0375-0473 33.3 µM -1.02529239119556 0.155042548925906 no 2916 0.152612622447155 4087 1713139 SGTC_1207 2099-0101 141 µM -1.02839199815906 0.154313931194242 no 2917 0.151882735512102 4131 5837381 SGTC_1490 4089-0339 670 nM -1.03319245338385 0.153189974634109 no 2918 0.150756921914217 4083 742542 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.03376667040997 0.153055894292699 no 2919 0.150622628255588 4070 16623 A steroid. SGTC_1821 st053465 65.6 µM -1.03442218007809 0.152902927142517 no 2920 0.150469419887134 4141 675086 SGTC_492 tmb-8 126 µM -1.03486916088701 0.152798679610929 no 2921 0.150365009277379 4073 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1763 st044482 94.5 µM -1.03526342355908 0.15270676645216 no 2922 0.150272953219141 4122 88505 SGTC_1211 1056-0033 32.3 µM -1.03539706864486 0.15267561853773 no 2923 0.150241757066319 4184 6741922 SGTC_2722 naftopidil 47.16 µM -1.03647682099603 0.152424121264362 no 2924 0.149989873792046 4032 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1981 st071826 47 µM -1.03687117910236 0.152332335466064 no 2925 0.149897948668431 4149 11838600 SGTC_3021 9087658 49.47 µM -1.03792275247029 0.152087763953476 no 2926 0.149653009961062 4123 25237042 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.04120439419591 0.151326207913678 no 2927 0.148890348381417 4162 688664 SGTC_390 dec-rvkr-cmk 16.7 µM -1.04360333389768 0.150771104007911 no 2928 0.148334474905274 4172 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2587 piperic acid 92.2 µM -1.04371225159692 0.150745933155105 no 2929 0.148309269884371 4131 5370536 SGTC_1326 1431-2094 10.8 µM -1.0463875323687 0.150128554817998 no 2930 0.147691073320665 4114 616278 SGTC_837 0091-0265 12.5 µM -1.04984613966615 0.149332908518243 no 2931 0.146894428975872 4094 759367 SGTC_2675 theaflavin digallate 100 µM -1.05078710438695 0.149116929343333 no 2932 0.146678189902874 4081 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1791 st048313 56.1 µM -1.05107964379441 0.149049825450477 no 2933 0.146611006222078 4151 1204976 SGTC_3201 9113999 49.47 µM -1.05154025250325 0.148944210019697 no 2934 0.146505266136619 4172 16649224 SGTC_3345 9148410 3.559 µM -1.0521955405245 0.148794041717047 no 2935 0.146354922542973 4107 4903596 SGTC_814 3342-0569 96 µM -1.05483358698921 0.14819052083571 no 2936 0.145750720302343 4218 4346283 SGTC_1699 st031318 29.054 µM -1.05732704022847 0.14762158708113 no 2937 0.14518117828813 4187 5340658 SGTC_2995 9067767 71.4286 µM -1.06013604507404 0.146982408291964 no 2938 0.144541355772243 4164 11673567 SGTC_820 1582-0060 59.9 µM -1.06362759310751 0.146190510190191 no 2939 0.143748718652773 4170 3848840 SGTC_2190 6049624 200 µM -1.06575797322993 0.145708741004919 no 2940 0.143266531735139 4034 2265554 SGTC_2492 derrusnin 100 µM -1.06626326056231 0.14559463090891 no 2941 0.143152326242461 4148 1715307 Part of coumarin class of compounds. SGTC_620 0109-0052 432 µM -1.06736690395716 0.145345601813091 no 2942 0.142903093684906 4154 493037 SGTC_924 2046-0044 21.3 µM -1.06790090154373 0.145225212068326 no 2943 0.14278260790791 4148 3623589 SGTC_1352 1496-0991 99 µM -1.06842728676076 0.145106604219773 no 2944 0.142663906934892 4138 3000039 SGTC_1003 4049-0218 100 µM -1.06875923889078 0.145031840572935 no 2945 0.14258908534647 4201 295161 SGTC_1608 st001473 40.5 µM -1.06932435532451 0.14490462234009 no 2946 0.142461769869865 4123 7292267 SGTC_2835 9006588 71.43 µM -1.06941303342928 0.144884666069376 no 2947 0.142441798499274 4226 2345538 SGTC_2099 5377090 177.372 µM -1.06962100979652 0.144837869975369 no 2948 0.142394967161401 4169 2243829 SGTC_2534 helenine 20.12 µM -1.07012204953285 0.14472517443271 no 2949 0.142282187689558 4159 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3229 9132204 49.47 µM -1.07021301327643 0.144704720897471 no 2950 0.142261719065108 4218 17682924 SGTC_385 1494-0393 12.4 µM -1.07142646677914 0.144432057595007 no 2951 0.141988858824282 4148 3090647 SGTC_134 0269-0018 6.916 µM -1.07209177800591 0.14428270904275 no 2952 0.141839405728551 4133 4378915 SGTC_3273 9137859 49.47 µM -1.0724083115256 0.144211690399504 no 2953 0.141768338199989 4233 2377234 SGTC_2258 7960471 200 µM -1.07749441321406 0.143073785101129 no 2954 0.140629722667379 4216 2974708 SGTC_833 3852-0053 558 µM -1.07949916102272 0.142626937349654 no 2955 0.140182633799325 4241 3123681 SGTC_512 prima-1 270 µM -1.08209314805548 0.142050153132375 no 2956 0.139605570066436 4180 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1120 ficusin 1.78878 µM -1.08216483327029 0.142034236066831 no 2957 0.13958964579568 4226 6199 A DNA cross-linker. SGTC_1561 5-methoxyflavone 52.9 µM -1.09039200458975 0.140215483591001 no 2958 0.13777025116593 4120 94525 SGTC_3098 9119039 49.47 µM -1.09041976429218 0.140209373748632 no 2959 0.137764139775054 4179 17161528 SGTC_741 4582-0002 126 µM -1.09064631500388 0.140159517253357 no 2960 0.137714270797132 4169 2912688 SGTC_2626 ethyl orsellinate 100 µM -1.09186230322391 0.139892123323501 no 2961 0.137446814582324 4158 75653 A natural product. SGTC_1018 4259-0013 28.1 µM -1.09188714754302 0.139886663712831 no 2962 0.137441353781894 4245 6801262 SGTC_1143 3454-2408 5.08 µM -1.09400279990338 0.139422274211396 no 2963 0.136976875113306 4182 X1143 SGTC_1932 st074806 40.9 µM -1.09479951372276 0.139247666225505 no 2964 0.136802239766389 4260 17251235 SGTC_3263 9137018 49.47 µM -1.09569098751016 0.139052467093892 no 2965 0.136607014046316 4156 43844957 SGTC_1706 st031321 9.9705 µM -1.09571647712006 0.139046888571269 no 2966 0.136601434825955 4213 6103185 SGTC_2217 6934799 96.0675 µM -1.09994863289393 0.138122773207657 no 2967 0.135677251698421 4167 675606 SGTC_2013 4024628 200 µM -1.10152030762349 0.137780657923338 no 2968 0.135335135535138 4246 5230760 SGTC_3309 9129340 25.759 µM -1.10179380264143 0.13772118383633 no 2969 0.135275662635553 4216 17158987 SGTC_51 1013-0126 23.419 µM -1.10390160264382 0.137263410538721 no 2970 0.134817911800021 4211 1627850 SGTC_1743 st037606 46.3785 µM -1.10403890494928 0.137233627234942 no 2971 0.134788130776076 4173 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_296 1222-0039 74.9 µM -1.10471340274824 0.137087380811472 no 2972 0.134641897001221 4205 5984176 SGTC_1010 4112-3296 15.2 µM -1.10706662056381 0.136577983790081 no 2973 0.134132562938525 4270 704384 SGTC_3163 9099914 49.47 µM -1.107402928427 0.136505289657741 no 2974 0.13405988019107 4221 16268368 SGTC_52 0329-0193 875 nM -1.10836294872941 0.136297923489427 no 2975 0.133852549801592 4283 3739292 SGTC_703 3875-0075 71.8 µM -1.11392967403557 0.135099749713187 no 2976 0.132654678972377 4255 2850814 SGTC_2514 salinomycin 42.74 µM -1.11667648389021 0.134511199552457 no 2977 0.132066338079957 4254 23682228 A polyether potassium ionophore. SGTC_1552 6-methylflavone 10.6 µM -1.11674602365642 0.134496322368621 no 2978 0.132051466705031 4134 689013 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.1170344288549 0.134434633655563 no 2979 0.131989802352489 4256 279621 SGTC_1540 guanosine 70.6 µM -1.11765417068465 0.13430213910026 no 2980 0.131857361610335 4097 6802 Guanosine is a purine nucleoside SGTC_1241 0364-0022 50.8 µM -1.11766347582358 0.134300150438944 no 2981 0.131855373772238 4223 4563895 SGTC_2909 7941780 10.49 µM -1.11925696229845 0.133959894380853 no 2982 0.131515265331988 4193 1243215 SGTC_2618 avocadyne 43.43 µM -1.12015047223046 0.133769363256237 no 2983 0.131324822754544 4128 3015189 SGTC_1910 st062352 60.4 µM -1.12404651486366 0.132940752775355 no 2984 0.130496646728547 4109 2245730 SGTC_1011 4112-3381 17.4 µM -1.12727957918892 0.132255832750197 no 2985 0.129812146752729 4294 2877139 SGTC_2119 5528445 120.635 µM -1.12812747623214 0.132076610323335 no 2986 0.12963304339282 4235 791935 SGTC_2813 7971799 71.43 µM -1.12855049159186 0.131987259001698 no 2987 0.129543752854598 4239 2234054 SGTC_517 1365-0151 113 µM -1.12868787185812 0.131958249856869 no 2988 0.129514763647686 4263 768657 SGTC_298 1391-0729 10 µM -1.12966291573461 0.131752486469543 no 2989 0.129309144550537 4154 3237558 SGTC_875 0709-0210 25.7 µM -1.13221621609415 0.131214713086964 no 2990 0.128771772088629 4227 6251364 SGTC_1954 st077032 68.9 µM -1.13304059435271 0.131041407627606 no 2991 0.128598603192079 4189 698907 SGTC_381 3461-2219 42.7 µM -1.13754587759708 0.130097075578008 no 2992 0.127655078640111 4227 2883159 SGTC_2824 7998404 51.95 µM -1.14070055136939 0.129438648707362 no 2993 0.126997278523702 4197 837851 SGTC_587 k089-0003 57 µM -1.14171259762453 0.129227909788217 no 2994 0.126786751333934 4125 9659696 SGTC_1829 berberine 14.4 µM -1.14592183657151 0.12835397001335 no 2995 0.125913747524897 4196 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_626 0214-0009 33 µM -1.1465092564404 0.128232334502228 no 2996 0.125792249710378 4289 3437874 SGTC_111 0083-0039 52.457 µM -1.15066715366556 0.127373657984608 no 2997 0.124934597202387 4130 759313 SGTC_2855 9016525 58.44 µM -1.15180468645424 0.127139436438078 no 2998 0.124700670836968 4195 43811474 SGTC_627 1391-0720 175 µM -1.15323597815654 0.126845155012168 no 2999 0.124406769964948 4216 997839 SGTC_1299 1079-1439 3.74 µM -1.15373483138943 0.126742699580497 no 3000 0.124304449560427 4206 323161 SGTC_2974 9094440 9.66 µM -1.15435437032096 0.126615537729576 no 3001 0.124177457122058 4250 25236134 SGTC_908 3448-7491 47.7 µM -1.15579934447701 0.126319298710758 no 3002 0.123881620621741 4243 1203031 SGTC_2942 9052777 62.25 µM -1.15615613724876 0.126246225836849 no 3003 0.123808648728578 4303 6469503 SGTC_2265 7929201 200 µM -1.15638068306436 0.126200252882577 no 3004 0.123762739648797 4226 1265108 SGTC_2816 7982706 58.44 µM -1.1565949093884 0.126156403593302 no 3005 0.123718951530835 4258 2981853 SGTC_325 2810-4341 181 µM -1.15776558217133 0.125916969985649 no 3006 0.123479856207165 4241 774970 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.15958360498534 0.125545764669543 no 3007 0.123109189635188 4292 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2344 7990960 76.95 µM -1.15958420862135 0.125545641545626 no 3008 0.123109066692853 4225 140813 SGTC_2113 5491891 107.031 µM -1.1596617024558 0.125529835791942 no 3009 0.123093284265235 4248 789979 SGTC_564 3555-0129 330 µM -1.16081597149084 0.125294573798551 no 3010 0.12285837320883 4122 563260 SGTC_2086 5274770 176.623 µM -1.1618852334171 0.125076912685374 no 3011 0.122641043026776 4288 689278 SGTC_695 3505-6186 243 µM -1.16384921969477 0.124677807999337 no 3012 0.122242560785996 4244 1819379 SGTC_3038 9091290 49.47 µM -1.16571075122874 0.12430034574486 no 3013 0.121865705919324 4286 25236843 SGTC_1057 3448-5381 134 µM -1.16630370574249 0.124180280530691 no 3014 0.12174583772789 4240 5497911 SGTC_1545 lovastatin 49.4 µM -1.16658618735221 0.12412311039252 no 3015 0.121688762053314 4290 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_555 4296-0685 37 µM -1.16718262507355 0.124002460631543 no 3016 0.12156831302129 4230 2908540 YHR072W ERG7 SGTC_344 k064-0035 6.43 µM -1.16897119915393 0.123641152983708 no 3017 0.12120761768533 4197 5088750 SGTC_165 k038-0023 64.381 µM -1.1704100980393 0.123351018361433 no 3018 0.12091798693731 4256 46368543 SGTC_1674 st016616 23.6 µM -1.17068911357333 0.123294813888202 no 3019 0.120861881331325 4204 625830 SGTC_2334 9017922 200 µM -1.17217898683519 0.12299499977141 no 3020 0.120562601516771 4312 3163164 SGTC_1208 2323-2347 50.3 µM -1.17266046469736 0.122898219111584 no 3021 0.12046599581953 4258 5412760 SGTC_3150 9097574 49.47 µM -1.17275603084906 0.122879015951529 no 3022 0.120446827520059 4305 17217476 SGTC_1044 1222-0021 1.78 µM -1.17340125178817 0.12274941965377 no 3023 0.120317467738924 4207 4306703 SGTC_3156 9099931 49.47 µM -1.17504622769651 0.122419450725621 no 3024 0.119988110882893 4297 18111053 SGTC_3051 9093778 49.47 µM -1.17714367769648 0.121999622697242 no 3025 0.119569082160138 4334 17217378 SGTC_2961 9083290 32.55 µM -1.17899435391076 0.121630029797932 no 3026 0.119200212044601 4207 17741490 SGTC_1786 berberine 21.6 µM -1.1796131826015 0.121506621139367 no 3027 0.119077048726156 4178 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2922 7999257 32.47 µM -1.18034240597466 0.121361310248641 no 3028 0.118932029290358 4235 2988377 SGTC_1145 3546-0597 10.2 µM -1.18096131264481 0.121238077842685 no 3029 0.118809046238912 4236 875334 SGTC_2880 9042983 58.44 µM -1.18102945408307 0.12122451537174 no 3030 0.118795511333448 4235 6464714 SGTC_1168 k815-0004 80.5 µM -1.18251598456111 0.120928910607376 no 3031 0.118500513424296 4237 642433 SGTC_1477 0139-0234 16 µM -1.1850314274313 0.120429857018318 no 3032 0.118002510655093 4276 620880 SGTC_2513 baicalein 25.65 µM -1.18524942923383 0.120386674753893 no 3033 0.117959420873569 4274 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_570 0987-0065 62.6 µM -1.18595490252882 0.120247007847945 no 3034 0.117820054792853 4087 3104428 SGTC_189 3970-0742 2.116 µM -1.18650239220969 0.120138696637005 no 3035 0.117711978663118 4240 2891807 SGTC_809 3998-0021 90 µM -1.18865456459531 0.119713593512558 no 3036 0.117287813358886 4229 715485 SGTC_127 0180-0333 59.125 µM -1.18912122606279 0.119621557345464 no 3037 0.11719598342309 4190 771601 SGTC_2896 9052656 71.43 µM -1.19070079054353 0.119310401999812 no 3038 0.11688553373624 4054 6469436 SGTC_3055 9094636 49.47 µM -1.19132296923287 0.119187997165639 no 3039 0.1167634100738 4312 25236176 SGTC_1174 0739-0097 51.1 µM -1.19265421536113 0.118926391178445 no 3040 0.116502411793899 4314 728447 SGTC_488 nitrendipine 139 µM -1.19371628123282 0.11871797337138 no 3041 0.116294484765263 4312 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2419 paclitaxel 166.5 µM -1.19443500621146 0.118577078611508 no 3042 0.116153925118095 4199 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1710 st031758 61.5 µM -1.19516736747736 0.1184336322595 no 3043 0.116010822717343 4319 5394341 SGTC_2098 5376439 882.5 nM -1.19947910298624 0.11759158671313 no 3044 0.115170852773406 4319 2844116 SGTC_735 3076-0345 636 µM -1.20021220845881 0.11744883999949 no 3045 0.115028467544923 4341 2888990 SGTC_1745 st081495 74 µM -1.20039577989882 0.117413115082721 no 3046 0.114992833534214 4151 13842402 YBL026W LSM2 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.20050966623502 0.117390955482058 no 3047 0.114970730409308 4282 390807 SGTC_339 3091-4833 71.4 µM -1.20219246154412 0.117063868270415 no 3048 0.114644484671653 4140 3240077 SGTC_415 dibenzyl ketone 100 µM -1.20823731836456 0.115894249015859 no 3049 0.113477995548048 4273 7593 SGTC_649 1123-0311 367 µM -1.2095784361993 0.115635884715605 no 3050 0.113220348369571 4199 693629 YIL048W NEO1 SGTC_2157 5649910 96.377 µM -1.21136175632063 0.115292964959485 no 3051 0.112878394876013 4277 2858091 SGTC_3264 9137442 49.47 µM -1.21530261033368 0.114537731985954 no 3052 0.112125348350943 4282 17015726 SGTC_2202 7226349 200 µM -1.21622322554298 0.114361812009675 no 3053 0.111949949259557 4269 844334 SGTC_2316 5844804 197.44 µM -1.21669062696546 0.114272570132951 no 3054 0.111860973300531 4298 776813 SGTC_1697 st025554 27.742 µM -1.21685348815886 0.114241486376687 no 3055 0.111829982431582 4295 1269519 SGTC_3178 9107506 49.47 µM -1.21935120178746 0.113765525835027 no 3056 0.111355461383754 4285 8897194 SGTC_3252 9135871 49.47 µM -1.2269219517521 0.112331494476728 no 3057 0.109925963514927 4307 17682838 SGTC_1831 st055328 12 µM -1.22704282989899 0.112308703300236 no 3058 0.109903246787117 4293 1103068 SGTC_3259 9138485 49.47 µM -1.22859450383532 0.112016433707618 no 3059 0.109611938601328 4318 17646153 SGTC_1480 1070-0044 41.2 µM -1.22891972029435 0.111955245706079 no 3060 0.109550953448563 4340 3124987 SGTC_3121 9125696 49.47 µM -1.23988816105357 0.109905561285666 no 3061 0.107508381699445 4431 1235365 SGTC_1845 st056753 3.01 µM -1.24149034015145 0.109608429095517 no 3062 0.107212332239726 4302 5375839 SGTC_3053 9095903 49.47 µM -1.24185935566038 0.109540075106132 no 3063 0.107144229194531 4443 17174018 SGTC_2699 st077704 54.6 µM -1.24262985208391 0.109397452144361 no 3064 0.10700213208905 4323 645852 SGTC_1393 3470-5649 58.2 µM -1.24263382474261 0.109396717130025 no 3065 0.107001399792635 4292 4108395 SGTC_3120 9124077 49.47 µM -1.24347213609393 0.109241693577563 no 3066 0.106846951293918 4454 18774327 YGL155W CDC43 SGTC_308 4092-1169 104 µM -1.24553031776083 0.108861756821032 no 3067 0.106468439172304 4272 2268590 YDL196W YDL196W SGTC_1364 1653-0028 37.6 µM -1.24638203806374 0.108704808970184 no 3068 0.106312086171776 4312 5718652 SGTC_764 1951-2361 146 µM -1.24707078994759 0.108578010620596 no 3069 0.106185771119919 4328 5438930 SGTC_2721 ifenprodil 61.44 µM -1.24788589036553 0.108428089163346 no 3070 0.106036424233713 4322 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_701 4424-0219 185 µM -1.24872096603009 0.108274648180838 no 3071 0.105883574837892 4357 2911779 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.25077874694377 0.107897208385432 no 3072 0.105507605471081 4192 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1264 0783-0040 158 µM -1.25217304998804 0.107642003344108 no 3073 0.105253406957828 4237 2855798 SGTC_2303 7774051 200 µM -1.25254422835031 0.107574138396181 no 3074 0.105185811343954 4340 2953184 SGTC_2442 5158906 48.48 µM -1.25413383732927 0.10728384863339 no 3075 0.104896681607899 4337 1893835 SGTC_2653 dihydrofissinolide 100 µM -1.25801023363223 0.106578321289294 no 3076 0.104194027630237 4376 6857746 SGTC_2153 5569715 200 µM -1.26395034679044 0.10550369352951 no 3077 0.103123924666575 4371 2054701 SGTC_2477 5967686 25.23 µM -1.26440593395593 0.105421597845427 no 3078 0.103042182061551 4315 776118 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.26446911418032 0.105410216574035 no 3079 0.103030849822378 4380 6710655 SGTC_2470 5664817 21.68 µM -1.26448443602667 0.105407456633993 no 3080 0.10302810177563 4372 2859561 SGTC_1036 k216-0215 33.5 µM -1.26629612855504 0.105081482987273 no 3081 0.10270354124571 4288 622330 SGTC_981 1488-1094 54.9 µM -1.26632489342484 0.105076313281451 no 3082 0.102698394085456 4310 3449522 SGTC_1280 0880-0253 10.1 µM -1.2724684588895 0.103976388174572 no 3083 0.101603361922141 4320 6836607 SGTC_1373 2887-0003 58.5 µM -1.27488673875321 0.103545724837393 no 3084 0.10117466676718 4291 776948 SGTC_2297 7971671 152.32 µM -1.27554960236918 0.103427904049094 no 3085 0.101057389604096 4348 909016 SGTC_1735 st034310 56.75 µM -1.2758685649711 0.10337124468719 no 3086 0.101000992461337 4390 871153 SGTC_3296 9122258 64.045 µM -1.27625567094383 0.103302510854986 no 3087 0.100932577420676 4324 4730474 SGTC_5 0352-0601 109.883 µM -1.27727333189591 0.103121975115538 no 3088 0.100752882633189 4248 762456 SGTC_1491 4138-0063 26.5 µM -1.27761918358106 0.103060672313574 no 3089 0.100691866578159 4338 23883227 SGTC_1131 3454-3128 32.3 µM -1.27779751268436 0.103029073520161 no 3090 0.100660415826144 4367 710982 SGTC_1085 doxorubicin 7.67 µM -1.27923132153641 0.102775267354155 no 3091 0.100407804593 4366 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2035 5154463 94.595 µM -1.28151039018396 0.102372772830388 no 3092 0.100007226397767 4366 2769623 SGTC_1864 st057645 30.4 µM -1.28154728061929 0.102366267242243 no 3093 0.100000751999309 4391 688666 SGTC_1137 ixabepilone 100 µM -1.28174622197301 0.102331189333157 no 3094 0.0999658423824248 4307 154225 A novel microtubule stabilizer. SGTC_1297 1068-0111 14.1 µM -1.28256115983209 0.102187588406024 no 3095 0.0998229324905533 4349 767057 SGTC_171 k064-0041 9.68 µM -1.28395348065866 0.101942585582035 no 3096 0.0995791164186785 4346 53325 SGTC_1857 st056007 79.3 µM -1.28481583462518 0.101791054094374 no 3097 0.0994283238261928 4319 619834 SGTC_2712 st079126 47.7 µM -1.28639639945824 0.101513745511251 no 3098 0.0991523771783612 4349 3152970 SGTC_173 1273-0061 2.693 µM -1.28943402918638 0.100982341908391 no 3099 0.0986236187258863 4322 2847414 YPL266W DIM1 SGTC_3295 9122362 53.5725 µM -1.29137133539958 0.100644489910274 no 3100 0.09828747266625 4349 4730473 SGTC_3346 9158254 43.5805 µM -1.29231894229341 0.100479534809566 no 3101 0.0981233573534223 4362 17639500 SGTC_430 0958-0115 16.4 µM -1.29367790943165 0.100243316411485 no 3102 0.0978883494166973 4296 6833180 SGTC_864 0469-0573 172 µM -1.2960789529106 0.0998269534318804 no 3103 0.0974741426613009 4335 689425 SGTC_3006 9075424 71.4286 µM -1.29866729150883 0.0993795281866244 no 3104 0.0970290668503318 4326 7465181 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.29874400336859 0.0993662900295066 no 3105 0.0970158987191073 4477 16725076 SGTC_774 k060-0086 136 µM -1.3001152726153 0.0991298676954711 no 3106 0.0967807319599137 4356 5911235 SGTC_1637 st007924 17.4 µM -1.30295579647637 0.0986414384898781 no 3107 0.0962949265762658 4280 683336 SGTC_985 1493-0307 8.71 µM -1.30302222435326 0.0986300373070725 no 3108 0.0962835871229633 4391 3278274 SGTC_2560 caryophyllene 100 µM -1.3038137711824 0.0984942563637329 no 3109 0.0961485430368123 4403 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1658 st012944 20 µM -1.30466273325348 0.098348778646997 no 3110 0.0960038582793681 4214 24207260 SGTC_2786 7743617 45.45 µM -1.30810684152968 0.0977602120185245 no 3111 0.0954185366360239 4309 583674 SGTC_723 4182-0001 115 µM -1.30856000349089 0.0976829634148395 no 3112 0.0953417183360625 4387 744821 YLR208W SEC13 SGTC_27 0485-0001 32.618 µM -1.30884302377346 0.097634740853451 no 3113 0.0952937649119816 4361 2054479 SGTC_2992 9074591 71.4286 µM -1.30999846014825 0.0974380523081184 no 3114 0.0950981782564369 4324 17741321 SGTC_85 0868-0259 160.055 µM -1.310215549207 0.097401129954971 no 3115 0.0950614634923761 4300 83173 SGTC_2607 solasodine 47.35 µM -1.3102337902653 0.097398027996193 no 3116 0.0950583789844835 4343 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_812 4251-0442 148 µM -1.31088539105781 0.0972872684200752 no 3117 0.0949482436027459 4388 5723007 SGTC_3136 9095672 49.47 µM -1.31389081444519 0.0967776003592788 no 3118 0.0944414751473068 4212 17217380 SGTC_2718 lomofungin 53.02 µM -1.31755779109445 0.0961584033238405 no 3119 0.0938258615705508 4353 5351222 A RNA synthesis inhibitor. SGTC_2191 5911152 200 µM -1.32050390653328 0.0956630429913288 no 3120 0.0933334163015571 4398 2875902 SGTC_1112 tnp00069 1.16933 µM -1.32065333893446 0.095637967529397 no 3121 0.0933084895486003 4379 145826 SGTC_3140 9094243 49.47 µM -1.32129328007 0.0955306370916013 no 3122 0.0932017968812638 4341 19291112 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.32144300673409 0.0955055378516959 no 3123 0.0931768470770578 4404 5106787 A p450 inhibitor. SGTC_1300 1094-0077 113 µM -1.32555650835789 0.0948178733197404 no 3124 0.0924933201071075 4350 5532636 SGTC_1962 st076595 64.5 µM -1.32611768443037 0.094724343628983 no 3125 0.0924003596523909 4357 279619 SGTC_1340 1486-1359 257 µM -1.32638903512796 0.0946791427410437 no 3126 0.0923554344223464 4323 4309068 SGTC_2254 7938975 95.19 µM -1.32665918799157 0.0946341571794864 no 3127 0.0923107235670411 4439 2969277 SGTC_1146 3579-1023 7 µM -1.32758015687365 0.0944809168478113 no 3128 0.092158421713553 4407 X1146 SGTC_1252 0493-0875 34.8 µM -1.32790777271865 0.0944264488743579 no 3129 0.0921042883244166 4366 3960963 SGTC_3274 9138298 49.47 µM -1.32963055791036 0.094140407134258 no 3130 0.0918200123885017 4361 17015756 SGTC_660 4031-1742 102 µM -1.33135794572281 0.0938542435204454 no 3131 0.0915356300210507 4274 6738706 SGTC_126 0417-1624 672.48 µM -1.33547004953751 0.093175605955178 no 3132 0.0908612757321602 4443 41912 YDL195W SEC31 SGTC_1567 st069303 68.4 µM -1.33622546310037 0.0930513321764292 no 3133 0.0907377953572191 4418 5581319 SGTC_596 1155-0152 116 µM -1.34273788480298 0.0919850447887296 no 3134 0.0896784314110584 4420 280313 SGTC_146 3448-8650 53.125 µM -1.34386606864559 0.0918012489467065 no 3135 0.0894958500643789 4369 2891488 YIL048W NEO1 SGTC_1049 3226-0134 66 µM -1.34404254327328 0.0917725235530574 no 3136 0.0894673150475668 4424 5702385 SGTC_3209 9113616 49.47 µM -1.34669056320212 0.0913422953026265 no 3137 0.0890399564083504 4436 16649353 SGTC_2832 7992762 51.95 µM -1.34876403080933 0.0910064606905003 no 3138 0.0887063857083883 4340 2985177 SGTC_2885 9057732 51.95 µM -1.34935639210568 0.0909106857567017 no 3139 0.088611260262998 4429 6471414 SGTC_1148 3909-7663 27.7 µM -1.35083449380843 0.090672027511374 no 3140 0.0883742279201945 4436 4084526 SGTC_972 1319-0219 195 µM -1.35138014996101 0.0905840420306849 no 3141 0.0882868445493527 4390 23903702 SGTC_3275 9138069 49.47 µM -1.35215347425888 0.0904594543008256 no 3142 0.0881631118952963 4467 17617007 SGTC_2037 5169046 200 µM -1.35539837331724 0.089938066090874 no 3143 0.0876453338181083 4455 5718022 SGTC_1881 5652484 16 µM -1.35708923674235 0.0896672659380649 no 3144 0.0873764289902201 4388 2255129 SGTC_2521 angolensin 13.4 µM -1.36066940715568 0.0890958854451001 no 3145 0.0868090933464806 4445 821428 A flavenoid. SGTC_2844 9010103 25.97 µM -1.36144232557605 0.0889728872706604 no 3146 0.0866869740436509 4394 2480525 SGTC_3115 9123671 49.47 µM -1.36435942656155 0.088509813819802 no 3147 0.0862272354925413 4558 3286988 SGTC_2436 5633522 8.09 µM -1.36834552841764 0.087879948813116 no 3148 0.0856019730008538 4402 5724242 SGTC_2182 6325192 200 µM -1.37062423968736 0.0875213826306365 no 3149 0.0852460613380203 4425 736248 SGTC_1902 st060212 70.5 µM -1.3726397036185 0.0872051505816559 no 3150 0.0849321912493964 4417 688944 SGTC_460 trequinsin 123 µM -1.37519126450349 0.0868060281375441 no 3151 0.0845360779057763 4504 5537 A vasodilator. SGTC_2719 novobiocin 32.65 µM -1.37602458671083 0.0866759736271269 no 3152 0.0844070106951839 4473 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2333 9017922 200 µM -1.37860008906171 0.0862749419981187 no 3153 0.0840090445423836 4441 3163164 SGTC_1756 st041558 35.5 µM -1.38271252123307 0.0856374743541364 no 3154 0.0833765155289733 4504 3955792 SGTC_2225 6654152 15.4 µM -1.38521635817397 0.0852510858869887 no 3155 0.0829931601155093 4359 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2231 micatex 6.853 µM -1.38737579000218 0.0849188958062919 no 3156 0.0826636016856871 4456 20737 An antifungal of unknown mechanism. SGTC_1062 mesoridazine 14.2 µM -1.38740759200519 0.0849140108961377 no 3157 0.0826587556407748 4463 4078 A neuroleptic. SGTC_279 1273-0055 2.93 µM -1.38966398659782 0.0845679574575364 no 3158 0.082315467776381 4459 2847562 SGTC_1856 st057054 55.7 µM -1.39103633935638 0.0843580036676937 no 3159 0.0821072037483929 4421 1266018 SGTC_1156 4092-0367 4.88 µM -1.39162946808727 0.0842673831169028 no 3160 0.082017315311117 4478 1357585 SGTC_994 3910-0338 138 µM -1.39491820795611 0.083766241675315 no 3161 0.0815202528726611 4499 3479481 SGTC_2947 9072639 7.68 µM -1.39608930052027 0.0835883310037108 no 3162 0.0813438026936795 4392 16488146 SGTC_162 k030-0015 37.8 µM -1.40284772722517 0.0825671442118442 no 3163 0.0803311256553795 4487 1809920 YMR134W ERG29 SGTC_2374 9071832 200 µM -1.40323798128552 0.0825084655435418 no 3164 0.0802729425625495 4371 17381698 SGTC_2838 9002687 71.43 µM -1.40716187225673 0.0819202122723419 no 3165 0.0796896973456385 4420 6457060 SGTC_1940 st075990 51.1 µM -1.41248072355355 0.081127885308673 no 3166 0.0789042313063185 4483 1084979 SGTC_2597 laccaic acid a 100 µM -1.41691060522632 0.0804724096613029 no 3167 0.0782545327301297 4427 5491415 A textile dye. SGTC_1929 genistein trimethyl ether 50.5 µM -1.41752952347949 0.0803811497266244 no 3168 0.0781640844380916 4415 136420 SGTC_2950 9072895 21.46 µM -1.4175603265276 0.0803766098390081 no 3169 0.0781595849739526 4397 17332245 SGTC_1725 st036284 20.55 µM -1.43570658861137 0.0777356716578724 no 3170 0.0755429248221638 4480 707914 SGTC_1818 st052136 56.3 µM -1.44195616024495 0.0768415467732705 no 3171 0.0746573707244468 4105 674169 SGTC_299 1273-0059 1.44 µM -1.44371810727805 0.0765908837313764 no 3172 0.074409142928945 4252 2848077 SGTC_2596 sinensetin 100 µM -1.44784360963398 0.0760064033884486 no 3173 0.0738303966538569 4469 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_778 3456-2434 196 µM -1.44792151370305 0.0759953990939028 no 3174 0.0738195010684697 4392 5539063 SGTC_1298 1079-1278 263 µM -1.45287222692058 0.0752985740468049 no 3175 0.0731296167130491 4449 2840950 SGTC_1912 st060209 90.8 µM -1.45626402531021 0.0748239888981578 no 3176 0.072659823162993 4445 688787 SGTC_322 k048-0136 19.3 µM -1.45788837512705 0.074597517321705 no 3177 0.0724356566884784 4518 6823282 SGTC_2281 7943571 200 µM -1.4611375282249 0.0741460813325833 no 3178 0.0719888515391812 4559 1244024 SGTC_2917 7979103 53.79 µM -1.46344650404153 0.0738265436764737 no 3179 0.0716726208155591 4469 2980565 SGTC_2779 methotrexate 400 µM -1.46369889947675 0.0737916787442125 no 3180 0.0716381181705449 4463 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_618 k072-0232 33.2 µM -1.46504396700967 0.0736060885027689 no 3181 0.0714544612955394 4515 5872756 YGL099W LSG1 SGTC_1150 3909-7983 10.9 µM -1.46704299836586 0.0733309249927763 no 3182 0.0711821793941129 4479 23965914 SGTC_2612 dictamnine 15.46 µM -1.46734421312814 0.0732895315588735 no 3183 0.0711412210137069 4408 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2203 7227154 166.4 µM -1.47215623663651 0.0726306764963701 no 3184 0.0704893461042789 4508 896304 SGTC_1906 st060206 94.7 µM -1.47321146861376 0.0724868040102044 no 3185 0.0703470117978147 4499 5133468 SGTC_2931 9014674 55.67 µM -1.47363323307459 0.0724293608879495 no 3186 0.0702901842177727 4430 2996810 SGTC_178 4092-0806 87.505 µM -1.47528003295535 0.072205405311663 no 3187 0.070068636136835 4363 2169044 SGTC_1392 3455-1037 33.9 µM -1.47656812867319 0.0720306017214655 no 3188 0.0698957201552252 4473 981132 SGTC_160 3453-0671 289.699 µM -1.47769362536855 0.0718781297111712 no 3189 0.0697449007032038 4478 5322268 SGTC_3147 9097027 49.47 µM -1.47849185558967 0.0717701428763232 no 3190 0.0696380877208229 4492 25236841 SGTC_1422 4031-0024 15.5 µM -1.48279260364416 0.0711904657416607 no 3191 0.069064760894103 4425 782427 SGTC_1996 st072960 66.8 µM -1.48772616006808 0.0705299301189622 no 3192 0.0684115628509513 4517 1719405 SGTC_1186 1319-0216 26 µM -1.49142946468689 0.0700372113963836 no 3193 0.0679243885463884 4525 4565136 SGTC_1414 3917-0015 5.4 µM -1.49601384516885 0.069430940212274 no 3194 0.0673250236366437 4485 6618702 SGTC_3337 9144342 33.5465 µM -1.49690291899992 0.0693138320853337 no 3195 0.0672092602954986 4481 17682949 SGTC_429 1112-0049 25.5 µM -1.50907637244401 0.0677256189066428 no 3196 0.0656396334129794 4466 2836170 SGTC_2904 7225135 42.03 µM -1.51166068186143 0.0673921020159358 no 3197 0.0653101029239904 4560 4446116 SGTC_1553 gossypol 38.6 µM -1.51260376823055 0.0672707090847656 no 3198 0.0651901682213953 4419 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_919 tnp00227 403.569 nM -1.51305733786607 0.0672123863870789 no 3199 0.0651325475059731 4460 1269246 A methoxyflavone. YNL221C POP1 SGTC_2271 7849410 118.62 µM -1.51326308338627 0.0671859432897556 no 3200 0.0651064229784761 4428 972430 SGTC_823 0417-1665 178 µM -1.51826095611469 0.066546068070574 no 3201 0.0644743131150652 4537 3429856 SGTC_960 1222-0186 7.7 µM -1.51966343556199 0.0663673595914021 no 3202 0.0642977928862427 4490 3126296 SGTC_772 k072-0172 35.3 µM -1.52006115942077 0.0663167480221698 no 3203 0.0642478025997673 4549 5861980 SGTC_342 k048-0088 23.3 µM -1.5210143275315 0.0661955761341954 no 3204 0.0641281209508913 4501 6820570 SGTC_935 2996-0153 430 µM -1.52279115109523 0.0659701545870634 no 3205 0.0639054822682177 4515 23738523 SGTC_1369 1866-0067 208 µM -1.52593023197889 0.0655733608324969 no 3206 0.0635136203316359 4523 3531355 SGTC_2131 toluylene red 5.2905 µM -1.52779177822557 0.0653389287495705 no 3207 0.063282122123944 4462 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_245 methotrexate 289.6 µM -1.53005058904068 0.0650553412075055 no 3208 0.0630021036654871 4460 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1816 st051957 91.6 µM -1.53460128831425 0.0644869151725748 no 3209 0.0624408980101366 4528 674121 SGTC_1375 2910-0797 186 µM -1.54018250078606 0.0637950450951105 no 3210 0.0617579370910069 4510 742508 SGTC_484 loperamide 105 µM -1.54936700913853 0.0626690815423442 no 3211 0.060646759875704 4624 3955 An opioid-receptor agonist. SGTC_1622 st003707 19.4 µM -1.55096749861126 0.0624744659229745 no 3212 0.060454736494648 4532 10140899 SGTC_1261 0712-0010 12.7 µM -1.56118324154332 0.0612433388526997 no 3213 0.0592402609612015 4500 2840123 SGTC_2048 5246248 200 µM -1.56163083085904 0.0611898352552632 no 3214 0.0591874910260544 4531 677046 SGTC_808 0711-0032 135 µM -1.56412000296887 0.0608929525959305 no 3215 0.0588946946213536 4496 4252555 SGTC_288 1315-0019 35.1 µM -1.57722947556435 0.0593479361253308 no 3216 0.0573713665360595 4566 6811474 SGTC_1209 2323-2347 50.3 µM -1.57919342428111 0.0591191457122238 no 3217 0.0571458488935919 4552 5412760 SGTC_2 0422-0095 29 µM -1.58713106738166 0.0582014904700037 no 3218 0.056241481447601 4457 6790840 SGTC_2930 9013230 14.89 µM -1.58942887460488 0.0579379447455847 no 3219 0.0559817999853837 4514 2995857 SGTC_476 mead acid 10 µM -1.58988079490607 0.0578862225491739 no 3220 0.05593083870825 4608 5312531 An omega 9 fatty acid. SGTC_3088 9117578 49.47 µM -1.60355584886298 0.056338214672764 no 3221 0.0544059946703867 4600 678341 SGTC_1419 3993-2473 62.6 µM -1.60457588114797 0.0562240681448262 no 3222 0.0542935864080509 4613 704026 SGTC_2056 5235370 200 µM -1.60679329404458 0.0559765580273745 no 3223 0.054049859900459 4475 5511916 SGTC_901 1112-0062 60.1 µM -1.61131368223693 0.0554746496604571 no 3224 0.0535556850473185 4540 1908457 SGTC_2701 st077767 14.721 µM -1.62077030625607 0.0544361552506666 no 3225 0.0525334544920601 4519 5721188 SGTC_1976 st070609 63.5 µM -1.63476732786802 0.0529273436991967 no 3226 0.0510489161592484 4512 682556 SGTC_1904 st060225 78 µM -1.63601513087727 0.0527944629492351 no 3227 0.0509182103547896 4547 66595 SGTC_2655 perillic acid 100 µM -1.63689179650104 0.0527012636736773 no 3228 0.0508265401690631 4603 5702197 An apoptosis inducer. SGTC_2072 5231554 129 µM -1.63695516922335 0.05269453151357 no 3229 0.0508199185775953 4621 789545 SGTC_451 chloral hydrate 100 µM -1.64255235665585 0.0521026224438572 no 3230 0.0502377925444482 4544 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_569 4130-2812 160 µM -1.65473633410772 0.0508324163994769 no 3231 0.0489889966913332 4451 743552 SGTC_2371 9071574 200 µM -1.65623391766043 0.0506780062542524 no 3232 0.048837228507295 4569 45596039 SGTC_926 2268-1401 59.4 µM -1.65737845396007 0.0505602494962939 no 3233 0.0487214923552729 4549 2931578 SGTC_398 bronopol 33.3 µM -1.66154581247311 0.0501333273232086 no 3234 0.0483019379895173 4495 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1503 4585-0012 61.3 µM -1.67054173206693 0.0492215449754931 no 3235 0.0474061149402584 4596 2922052 SGTC_903 1134-0042 114 µM -1.6747930757303 0.0487952820115828 no 3236 0.0469874189624077 4595 701009 SGTC_25 0118-0223 35.662 µM -1.67765559580944 0.0485099357787103 no 3237 0.0467071763403997 4563 5333628 SGTC_2704 st078022 71.1 µM -1.68490594036088 0.0477931631616125 no 3238 0.0460033601503959 4615 54697681 SGTC_966 1300-0360 30.2 µM -1.68895620198701 0.0473964591504491 no 3239 0.0456139117943978 4567 70588 SGTC_623 k072-0108 16.9 µM -1.69048899479319 0.0472470192737242 no 3240 0.0454672209705693 4560 5382803 SGTC_1386 3228-0095 33.8 µM -1.69156115055676 0.0471427139225034 no 3241 0.0453648395465008 4580 870181 SGTC_2438 5259590 200 µM -1.69475342264105 0.046833244431533 no 3242 0.0450611033180357 4614 1201127 SGTC_1853 st056710 91.2 µM -1.70132614960116 0.0462011944520932 no 3243 0.0444408801343119 4607 269167 SGTC_265 mycophenolic acid 32.932 µM -1.70134806215164 0.0461990988004729 no 3244 0.0444388239601627 4638 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_224 benfluorex 43.875 µM -1.70675211357753 0.0456845976952179 no 3245 0.0439340682107787 4598 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3014 9081533 49.47 µM -1.71017487584556 0.0453611176969987 no 3246 0.0436167700722917 4603 21367265 SGTC_2287 7945887 168.79 µM -1.72192940467162 0.0442642198519268 no 3247 0.0425411537853856 4606 1245853 SGTC_152 4469-0003 551.229 µM -1.72367762981936 0.0441029223141118 no 3248 0.0423830278003586 4573 697280 SGTC_1442 4112-3290 3 µM -1.73264635927898 0.0432828721890991 no 3249 0.0415792720042568 4607 704353 SGTC_3340 9146634 11.102 µM -1.73370274814545 0.0431870978108681 no 3250 0.0414854193368742 4590 4907387 SGTC_2356 9061756 188.97 µM -1.73415255759502 0.0431463691559024 no 3251 0.0414455090950331 4621 20104043 SGTC_755 1995-0008 37.3 µM -1.73500393202591 0.0430693651485864 no 3252 0.0413700543777767 4588 689533 SGTC_1301 naphtanilide LB 4.81 µM -1.73589112898367 0.0429892392782758 no 3253 0.0412915433203194 4637 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2690 usnic acid 100 µM -1.7375371219624 0.042840902904167 no 3254 0.0411462037551797 4598 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1949 st076024 69.1 µM -1.74238357662279 0.0424065427729519 no 3255 0.0407206738784117 4571 2921930 SGTC_1632 st005650 90 µM -1.74534101015538 0.0421432396082232 no 3256 0.0404627636731067 4618 2759605 SGTC_3092 9117248 49.47 µM -1.74629565713729 0.042058529479941 no 3257 0.0403797950636293 4711 17141857 SGTC_1508 1080-0625 72.9 µM -1.7477901328399 0.0419261947199151 no 3258 0.0402501872667744 4568 767111 SGTC_2706 st078239 82.5 µM -1.75190753980574 0.041563344369656 no 3259 0.0398948539337062 4587 15434492 SGTC_3300 9124615 50.48 µM -1.75760328965519 0.0410655994866065 no 3260 0.0394075166148927 4607 24824903 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.75832824170175 0.0410025950135719 no 3261 0.0393458375106862 4595 229346 A bile salt which induces apoptosis. SGTC_1232 0279-0259 161 µM -1.76048668370695 0.0408154722062382 no 3262 0.0391626616808734 4597 1560000 SGTC_2158 5657123 3.6195 µM -1.76390361426917 0.0405206638080358 no 3263 0.0388741041297355 4621 2858827 SGTC_1405 3909-7894 12 µM -1.76784023126208 0.0401831630415612 no 3264 0.0385438085291011 4609 7104060 SGTC_1680 diphenhydramine 100 µM -1.76906810174558 0.0400783615899445 no 3265 0.0384412551777028 4558 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1605 st000082 49.1 µM -1.77803798342476 0.0393194825829166 no 3266 0.0376988083718185 4589 1114022 SGTC_3102 9121669 49.47 µM -1.81586136641798 0.0362471097932172 no 3267 0.0346958204617858 4662 41905072 SGTC_545 4218-0007 221 µM -1.8269617209985 0.0353836903005973 no 3268 0.0338527625184557 4635 2840508 SGTC_538 2922-0838 53.3 µM -1.82796092988766 0.0353068032807601 no 3269 0.0337777077591515 4655 777039 SGTC_1342 1486-1464 234 µM -1.8280171553976 0.0353024809217459 no 3270 0.0337734884978551 4651 3253938 SGTC_1325 1431-0015 227 µM -1.83517269932039 0.0347559276686404 no 3271 0.0332400524394664 4629 1103340 SGTC_3290 9121031 71.43 µM -1.83535428865867 0.0347421484646571 no 3272 0.0332266060157177 4645 17014854 SGTC_3161 9100388 49.47 µM -1.83863636847429 0.0344938728398798 no 3273 0.0329843441563757 4691 25236368 SGTC_1951 sophoraflavanone G 9.2 µM -1.85026323881719 0.0336260509667816 no 3274 0.0321378091419854 4593 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_817 1391-0715 46 µM -1.85518452508833 0.0332641816041966 no 3275 0.0317849403679979 4635 1353946 SGTC_3223 9129970 49.47 µM -1.86301436871916 0.0326950572333813 no 3276 0.0312301223399312 4643 17248386 SGTC_2767 sibutramine 71.45 µM -1.86511209531329 0.0325439519136496 no 3277 0.0310828467611778 4630 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_112 phenothiazine 287.218 µM -1.87554258623793 0.0318011427729514 no 3278 0.0303590582590338 4614 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3112 9123419 49.47 µM -1.88361299831825 0.0312360664194971 no 3279 0.029808671172197 4685 17015854 SGTC_1335 1486-0900 202 µM -1.89722175156059 0.0303020264177742 no 3280 0.0288993386064029 4661 X1335 SGTC_1172 0370-0043 85 µM -1.89788958151127 0.0302567920623705 no 3281 0.028855314544864 4670 376585 SGTC_909 3448-9333 149 µM -1.90022370193002 0.0300991336925415 no 3282 0.0287018845506813 4599 3344074 SGTC_1061 3448-9325 110 µM -1.90524825463456 0.0297620602761567 no 3283 0.0283739041552176 4635 723482 SGTC_2432 5630864 12.22 µM -1.924041656428 0.0285289470038061 no 3284 0.0271746811105183 4659 5714970 SGTC_3109 9122853 49.47 µM -1.92508002215763 0.0284620732685405 no 3285 0.0271096739309589 4688 1234709 SGTC_1810 st050138 53 µM -1.92663824586955 0.028361963930349 no 3286 0.0270123644092092 4686 3444541 SGTC_3066 9117245 49.47 µM -1.93360149495908 0.0279181780844342 no 3287 0.0265810716637639 4687 17176980 SGTC_1629 st005085 44.9 µM -1.93656532640924 0.0277310482070644 no 3288 0.0263992499363535 4638 24207091 SGTC_1602 st001878 87.6 µM -1.95209841596421 0.0267673365871959 no 3289 0.025463260637828 4646 595405 YLR310C CDC25 SGTC_1963 st076565 50.3 µM -1.95475185512599 0.026605540448345 no 3290 0.0253061831420498 4696 4914280 SGTC_1920 st075728 45.7 µM -1.95501743681984 0.026589391408391 no 3291 0.0252905061058839 4641 3400306 SGTC_193 1273-0060 1.558 µM -1.97819799875954 0.0252110831881708 no 3292 0.0239531872069631 4573 2847393 YHR072W ERG7 SGTC_258 haloperidol 50.781 µM -1.98582924145998 0.0247706406800457 no 3293 0.0235261438448767 4670 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1574 spiramycin 23.7 µM -1.98699714375695 0.0247038072425015 no 3294 0.0234613566834005 4670 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2759 disulfiram 3.38 µM -1.98960017920096 0.0245553922302554 no 3295 0.0233174982034115 4590 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1181 1222-0449 220 µM -1.99510885229841 0.0242437753417924 no 3296 0.0230155045448095 4703 658318 SGTC_541 4513-1321 94 µM -2.0026711510195 0.0238214028282486 no 3297 0.0226062986367867 4667 747515 SGTC_507 nimesulide 162 µM -2.0086898305149 0.0234896815469388 no 3298 0.0222850189394577 4691 4495 A COX2 inhibitor. SGTC_962 1254-0300 21.5 µM -2.01278017174507 0.023266466190872 no 3299 0.0220688803884937 4674 7340576 SGTC_1714 st033236 13.627 µM -2.02786985374873 0.0224583848933902 no 3300 0.0212867663153773 4669 2916566 SGTC_371 0195-0006 7.36 µM -2.02978051027976 0.0223577741372411 no 3301 0.0211894274520784 4556 3928593 SGTC_1813 st051246 8.6015 µM -2.05276311352553 0.0211770646962192 no 3302 0.0200477788001839 4675 5291959 SGTC_40 0327-0103 19.753 µM -2.05356221489301 0.0211369790283177 no 3303 0.0200090411928019 4560 409036 SGTC_3135 9127742 49.47 µM -2.06692301723206 0.0204762066784235 no 3304 0.0193707042408925 4725 3643468 SGTC_2821 7996764 71.43 µM -2.07518542550585 0.0200764047253676 no 3305 0.0189846764316121 4657 2987135 SGTC_1 0258-0098 57.368 µM -2.08394070651577 0.0196599985829397 no 3306 0.0185827805099252 4624 6790032 YDR047W HEM12 SGTC_97 0535-0701 19.132 µM -2.10134369610022 0.0188540477920894 no 3307 0.0178054032996851 4633 2832013 YGL099W LSG1 SGTC_1347 1493-0251 600 nM -2.11235049989675 0.018358960865573 no 3308 0.0173281986825104 4727 3986378 SGTC_1060 3448-7350 82 µM -2.12032387596633 0.0180072729014358 no 3309 0.0169893707465834 4677 570178 SGTC_215 1287-0124 461.5 µM -2.1258228216628 0.0177680873096886 no 3310 0.0167590075163703 4741 5560863 SGTC_661 1304-0007 33.6 µM -2.1333031169753 0.0174470749719654 no 3311 0.016449934348267 4732 3117130 SGTC_3085 9117376 49.47 µM -2.14249348144377 0.0170594674903224 no 3312 0.0160768963309259 4735 16480349 SGTC_3070 9117005 49.47 µM -2.14847243516222 0.0168112740850916 no 3313 0.0158381219389331 4756 8779016 SGTC_2105 5350118 200 µM -2.15464883534209 0.0165581340253231 no 3314 0.0155946622117536 4702 2133313 SGTC_2165 5727197 32.143 µM -2.16677545248963 0.0160706044895871 no 3315 0.0151259900347968 4703 1361712 SGTC_2960 9079389 5.97 µM -2.1755092090142 0.0157271462265895 no 3316 0.0147959893871271 4683 16457355 SGTC_1562 morin hydrate 59.1 µM -2.18031589749042 0.0155408217710602 no 3317 0.0146170267263467 4716 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2801 7907800 81.82 µM -2.18044541164589 0.015535827662838 no 3318 0.0146122305368208 4693 6620925 SGTC_3037 9091026 49.47 µM -2.19777301221933 0.0148799714059606 no 3319 0.0139826427780698 4616 25236398 YIL048W NEO1 SGTC_2606 farnesol 9.78 µM -2.22301368626575 0.0139672637474607 no 3320 0.0131074385566561 4693 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2006 4011487 200 µM -2.25238344133234 0.0129663758378222 no 3321 0.0121490256108833 4678 45595294 SGTC_1922 5578187 25 µM -2.26391248363219 0.0125907742456352 no 3322 0.0117897489958432 4698 1350412 SGTC_2604 4'-hydroxychalcone 11.32 µM -2.270371657249 0.0123844873261655 no 3323 0.0115925213261385 4698 5282362 SGTC_2900 5328528 85.29 µM -2.3023416101416 0.0114060120850833 no 3324 0.0106579575021764 4707 795359 SGTC_1144 3486-0183 12.5 µM -2.31157411683636 0.0111362453510847 no 3325 0.0104005821851993 4761 6744069 SGTC_659 k018-0002 107 µM -2.31687243519042 0.0109839519133948 no 3326 0.0102553408654284 4730 6797879 YHR007C ERG11 SGTC_1323 1348-1351 11.2 µM -2.31911624082168 0.0109200047150245 no 3327 0.0101943671940371 4730 6989654 SGTC_2906 7926292 26.41 µM -2.33449166262611 0.0104904665109323 no 3328 0.00978499606259834 4729 2966319 SGTC_496 calpeptin 138 µM -2.36380931827102 0.00971208978846497 no 3329 0.00904405990872195 4733 73364 A calpain inhibitor. SGTC_2636 apigenin dimethyl ether 100 µM -2.39492145190978 0.00894172217609431 no 3330 0.00831196306515972 4699 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_815 1582-0027 36.9 µM -2.42422885209431 0.00826555499966542 no 3331 0.00767046730380275 4756 3128206 SGTC_2001 4023502 57.655 µM -2.43447197088811 0.00804005257439841 no 3332 0.00745676742254126 4740 108941 YCR052W RSC6 SGTC_310 1273-0058 1.06 µM -2.46049863437819 0.00749123386231016 no 3333 0.00693720500117858 4414 2734232 SGTC_2403 6032726 181.2 µM -2.48607074593635 0.00698441750639919 no 3334 0.00645811429237087 4740 2881040 SGTC_912 3474-0017 2.18 µM -2.49416592311841 0.00683041135803665 no 3335 0.00631267558234946 4747 3360550 SGTC_172 1112-0046 2.638 µM -2.50777034639626 0.00657834346937569 no 3336 0.00607478009604648 4747 2802135 YIL048W NEO1 SGTC_1033 k072-0102 21.3 µM -2.66702527996226 0.00418437897771363 no 3337 0.00382629576903488 4751 5965931 SGTC_1888 azatryptophan 97.5 µM -2.69834367064533 0.00381798191930169 no 3338 0.00348427294820521 4771 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3067 9117431 49.47 µM -2.73030013951224 0.00347402248618128 no 3339 0.00316383437909319 4772 17150885 SGTC_317 4495-0002 170 µM -2.78131574803608 0.00298231355269219 no 3340 0.00270695263973764 4778 15991618 SGTC_98 0074-0023 107.663 µM -2.79156038250767 0.00289148603371652 no 3341 0.00262272847416348 4769 3563821 SGTC_3123 9126162 49.47 µM -2.92525680855242 0.00191453267656104 no 3342 0.00172086033834644 4785 25239884 SGTC_1055 3448-0672 86 µM -2.9567618278701 0.00173319935174072 no 3343 0.0015544407829347 4776 748378 SGTC_2758 dehydroepiandrosterone 69.35 µM -2.97442316963721 0.00163852312988201 no 3344 0.00146769977275984 4764 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2414 st077232 92.9 µM -3.00116085674347 0.00150413203886864 no 3345 0.00134476223973824 4770 729801 SGTC_2404 5161160 200 µM -3.00258437284011 0.00149726724980173 no 3346 0.00133848878147366 4777 2831543 SGTC_1892 st058411 7.36 µM -3.04680517052607 0.001297741469714 no 3347 0.00115643784463311 4785 3934738 SGTC_542 3381-0244 89.3 µM -3.11605271214948 0.00103365763111174 no 3348 0.000916447528445987 4794 1112843 SGTC_101 0490-5701 117.494 µM -3.14889175487309 0.000926522382654756 yes 3349 0.000819454447047364 4777 4661669 SGTC_944 3370-0224 231 µM -3.15087679354996 0.000920385441574952 yes 3350 0.000813905705584312 4782 4580514 SGTC_533 1222-0222 6.71 µM -3.49700071172689 0.000273412206778279 yes 3351 0.000235260288484002 4803 3982874 SGTC_314 1671-0008 2.74 µM -3.53249900679545 0.000239914615003284 yes 3352 0.000205825886198475 4758 3913060 SGTC_1887 st057648 70.8 µM -3.74431980242689 0.00010736858607614 yes 3353 9.04415703616781e-05 4809 688672 SGTC_1899 st063254 59.6 µM -3.86907612138986 6.55836233166349e-05 yes 3354 5.46242665050042e-05 4805 3093813 SGTC_2798 7813637 45.45 µM -4.05704774501687 3.03666844459352e-05 yes 3355 2.48484627296143e-05 4805 956368 SGTC_2517 totarol 10 µM -4.24167535503095 1.38054222740723e-05 yes 3356 1.10928725186795e-05 4805 460178 An antibacterial membrane disruptor. YGL001C ERG26