SGTCid condition conc unit YPR014C|YPR014C.score YPR014C|YPR014C.strain.pval YPR014C|YPR014C.strain.significant YPR014C|YPR014C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1860 st056228 74.6 µM 8.48292791223815 2.75224635006012e-16 yes 1 1.09798361533055e-17 1 688679
SGTC_74 000s-0487 160.283 µM 6.44946001937119 3.22831161005279e-10 yes 2 5.61246831648306e-11 4 677548
SGTC_1008 4106-0037 6 µM 6.06107030638436 3.08726768600878e-09 yes 3 6.7609353030319e-10 5 2905394
SGTC_2971 9092186 9.93 µM 5.71618108688272 2.05388146967619e-08 yes 4 5.44723196260761e-09 9 25236400
SGTC_1755 st041960 45.185 µM 5.45416173444827 8.08847605250707e-08 yes 5 2.46022015526767e-08 8 2257073
SGTC_937 3122-0005 46.7 µM 5.3497497476562 1.37369686367202e-07 yes 6 4.40379689509053e-08 10 759535
SGTC_966 1300-0360 30.2 µM 5.16891749189234 3.36195191589312e-07 yes 7 1.17726905285879e-07 6 70588
SGTC_1177 0983-0204 23.6 µM 4.94574409022774 9.75916781587564e-07 yes 8 3.79267779071734e-07 3 766818
SGTC_1073 triclabendazole 3.09 µM 4.89171000605206 1.2550708598403e-06 yes 9 4.99818282101934e-07 14 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_911 3456-4043 236 µM 4.63012736545428 4.09424341332755e-06 yes 10 1.82720439519112e-06 17 914281
SGTC_480 am 92016 50 µM 4.5921999299656 4.8362771796522e-06 yes 11 2.19298941543653e-06 4 2129 K+ channel blocker.
SGTC_193 1273-0060 1.558 µM 4.57663924973802 5.17648063227921e-06 yes 12 2.36252616415449e-06 4 2847393 YHR072W ERG7
SGTC_325 2810-4341 181 µM 4.22934943870454 2.23639557280504e-05 yes 13 1.17184033922981e-05 9 774970
SGTC_1617 st002906 78 µM 4.18915720558926 2.63154758570177e-05 yes 14 1.39996194604569e-05 23 5150859
SGTC_2639 lactacystin 53 µM 4.13524356524412 3.26632724981272e-05 yes 15 1.77289180670338e-05 18 3870 A proteasome inhibitor.
SGTC_464 bw-b 70c 158 µM 4.01258216340471 5.29151043229135e-05 yes 16 3.00290823854377e-05 23 5353454
SGTC_2162 5663267 200 µM 3.95954228839149 6.4932139186418e-05 yes 17 3.75467735065896e-05 12 6456493
SGTC_270 tamoxifen 5.46 µM 3.89637631900461 8.25956102337963e-05 yes 18 4.88213172164073e-05 31 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_219 mitoxanthrone 164.414 µM 3.89159190721725 8.41031286173717e-05 yes 19 4.97943253928116e-05 53 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1152 3909-8331 15.9 µM 3.70163870207361 0.000169781482304759 yes 20 0.000107105751479325 13 16001939
SGTC_3181 9108277 49.47 µM 3.6975229476996 0.00017232728623319 yes 21 0.000108856771873948 22 17097298
SGTC_540 1187-0821 17.3 µM 3.66297375704413 0.000195149963514432 yes 22 0.000124652044224149 22 847520
SGTC_2324 6149169 200 µM 3.61717335509685 0.000229773468877085 yes 23 0.000148918918486412 26 2888231
SGTC_727 3032-0951 202 µM 3.5641606879612 0.000276976963687967 yes 24 0.000182511150200297 38 3652836
SGTC_1603 st002045 67.8 µM 3.54419655020433 0.000296985827876938 yes 25 0.000196905771746823 25 5887985
SGTC_2327 6189656 200 µM 3.54274990690007 0.000298486779907985 yes 26 0.000197989018086832 29 5349088
SGTC_2936 9038235 15.59 µM 3.52759011901706 0.000314646038049436 yes 27 0.00020968049043645 35 4749415
SGTC_165 k038-0023 64.381 µM 3.51590086667037 0.000327657671382738 yes 28 0.000219132296317181 105 46368543
SGTC_1864 st057645 30.4 µM 3.49555581004934 0.000351504460580871 yes 29 0.000236537754140526 14 688666
SGTC_72 0744-0168 198.391 µM 3.47762608896085 0.00037384719252898 yes 30 0.000252937530245847 41 677577
SGTC_10 0279-0212 42.575 µM 3.41714312340458 0.00045931660035856 yes 31 0.000316410007978856 158 39851 YBR002C RER2
SGTC_1160 4092-0570 10.5 µM 3.39905320130316 0.000488199916361632 yes 32 0.000338097808834002 64 4994975
SGTC_2569 tetrandrine 100 µM 3.39731198688961 0.000491066994328217 yes 33 0.000340256664755522 42 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1199 1638-0010 4.46 µM 3.37160461272585 0.000535251816133921 yes 34 0.00037365825429259 48 3111136
SGTC_1454 4239-0054 42.6 µM 3.36021603766598 0.000555978013092702 yes 35 0.00038940772994293 53 1340767
SGTC_527 4476-4215 268 µM 3.34363111567259 0.000587490945183309 yes 36 0.000413448044259774 59 4418754
SGTC_2829 7992743 58.44 µM 3.33921229605894 0.00059616126642417 yes 37 0.000420081647371666 61 16462845
SGTC_610 4215-0184 155 µM 3.32574547373943 0.000623319455378762 yes 38 0.000440912067003595 27 5605015
SGTC_65 0798-0905 34.986 µM 3.26759865585964 0.000754208508040081 yes 39 0.000542320281515009 137 3602145
SGTC_988 1497-1057 103 µM 3.22529456034526 0.000864864220135549 yes 40 0.000629215588582201 30 3533044
SGTC_2809 7964133 12.99 µM 3.21431390000953 0.000895931660806468 yes 41 0.000653783218978615 79 1253665
SGTC_2788 5282734 71.43 µM 3.18790436503762 0.000974897898676114 yes 42 0.000716539629356151 88 743706
SGTC_2619 obliquin 87.91 µM 3.1711951402795 0.00102810848320476 no 43 0.000759065616377349 205 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2496 diffractaic acid 79.83 µM 3.13023490042213 0.00117000913586068 no 44 0.000873332857997286 51 94870 An apoptosis inducer which activates caspases.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 3.09053220170852 0.00132445747744829 no 45 0.000998990692474397 65 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_679 0422-0091 41.4 µM 3.08489348348558 0.00134784433968343 no 46 0.0010181253175797 74 627384 YHR062C RPP1
SGTC_2967 9089538 49.85 µM 3.08250291576997 0.00135787275821697 no 47 0.00102633859756284 75 728216
SGTC_1856 st057054 55.7 µM 3.08170376441595 0.00136124036825913 no 48 0.00102909777208989 55 1266018
SGTC_1750 st081859 2.357 µM 3.06936802488521 0.00141420016924774 no 49 0.00107256079638456 251 5291695
SGTC_1830 st055982 50.3 µM 3.04945544853411 0.00150367050691301 no 50 0.00114628316625199 63 455313 An antimicrobial agent.
SGTC_716 1683-5115 658 µM 3.04267011368313 0.00153531836574167 no 51 0.00117244618818853 61 723597
SGTC_935 2996-0153 430 µM 3.01825873052007 0.00165426526122863 no 52 0.00127115874605296 61 23738523
SGTC_2476 5806916 10.51 µM 2.99958743232546 0.00175084288113903 no 53 0.00135172760096961 51 2870194
SGTC_2689 tacrolimus 100 µM 2.98676893897854 0.00182008753390737 no 54 0.00140971364326278 95 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2362 9071156 126 µM 2.97870688421388 0.00186490450376219 no 55 0.00144733770796969 46 653133
SGTC_3205 9113483 49.47 µM 2.96313619490072 0.00195431252439937 no 56 0.00152260898874551 89 17018033
SGTC_258 haloperidol 50.781 µM 2.94941430018564 0.00203631308846446 no 57 0.00159188429465213 85 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2443 5493264 126.67 µM 2.93581422774075 0.00212065484738439 no 58 0.00166336742885802 69 5340055
SGTC_801 0866-0028 10.1 µM 2.93234375982462 0.00214267859913989 no 59 0.00168207073344847 96 6849771
SGTC_3047 9092122 49.47 µM 2.86147319574174 0.00264024215128054 no 60 0.00210838579310882 75 17173831
SGTC_3017 9080681 49.47 µM 2.85199655346333 0.00271415081635834 no 61 0.00217227858377849 67 16451914
SGTC_919 tnp00227 403.569 nM 2.81828448766378 0.00299245563676361 no 62 0.00241405052909955 112 1269246 A methoxyflavone. YNL221C POP1
SGTC_121 0557-0495 61.343 µM 2.8178994307735 0.00299577777965614 no 63 0.00241694740086934 158 3104427
SGTC_737 1950-0117 57.9 µM 2.81014513697282 0.00306339038340759 no 64 0.00247595817864259 78 5393513
SGTC_2366 9070441 60.58 µM 2.80626802841649 0.00309770906083396 no 65 0.00250594921687796 94 6837235
SGTC_2985 9022375 71.43 µM 2.79092658863394 0.00323692602466566 no 66 0.00262786956490696 95 4939335
SGTC_2713 st079149 53.4 µM 2.7726679660689 0.00340993376785569 no 67 0.00277994090221685 88 3103253
SGTC_3061 glucosamine 200 µM 2.75263542484839 0.00360927068783029 no 68 0.00295588449629286 60 91431 and experimental redox chemotherapeutic
SGTC_1505 k297-0037 20.6 µM 2.73056319533447 0.00384095987178677 no 69 0.00316131049454591 86 4089396
SGTC_411 enrofloxacin 100 µM 2.72945620728356 0.00385292321956117 no 70 0.00317194371866561 52 71188 A bacterial gyrase inhibitor.
SGTC_1002 4049-0206 172 µM 2.71404789073307 0.00402294484171239 no 71 0.00332332783520083 125 4662749
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.68984873461508 0.00430355099210976 no 72 0.00357422066824876 130 676296 Flavone; oxidizing agent.
SGTC_864 0469-0573 172 µM 2.66262991024337 0.00463997219348433 no 73 0.00387663175517539 94 689425
SGTC_1001 4048-4355 44.4 µM 2.64089382552051 0.00492527600937235 no 74 0.00413438140106181 104 21824233
SGTC_689 0833-0039 98 µM 2.62526301077089 0.00514000045787832 no 75 0.00432910292122524 90 5374726
SGTC_1694 st024011 44.9 µM 2.6187810824743 0.00523146150123944 no 76 0.00441222790194178 117 2787533
SGTC_933 2914-0560 114 µM 2.60891608695941 0.00537343782197212 no 77 0.00454147562124245 114 463887
SGTC_1684 st024538 14.6195 µM 2.60777599243875 0.0053900648424152 no 78 0.00455662854802864 98 6732859
SGTC_2176 5809774 33.9695 µM 2.60563210494343 0.0054214549881143 no 79 0.00458524510955182 73 2870539
SGTC_1120 ficusin 1.78878 µM 2.59877615838546 0.00552293112836555 no 80 0.00467783789836684 100 6199 A DNA cross-linker.
SGTC_3048 9093155 49.47 µM 2.59342189350619 0.00560335050225166 no 81 0.00475130604570015 52 25236002
SGTC_3142 9086498 49.47 µM 2.58484368629115 0.00573436142609761 no 82 0.00487115771317597 110 25236367
SGTC_407 eburnamonine 100 µM 2.57759758972346 0.00584713843553401 no 83 0.00497448919208863 90 3195
SGTC_730 1436-0052 41.2 µM 2.57715793834467 0.00585404397885631 no 84 0.00498082112492482 75 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1334 1486-0610 236 µM 2.57642489979382 0.0058655738019025 no 85 0.00499139443467984 98 3742339
SGTC_3287 9117173 37.0625 µM 2.57580656782391 0.00587531508412834 no 86 0.0050003287623675 40 2789709
SGTC_807 1315-0151 48 µM 2.57458753432848 0.00589456193705147 no 87 0.00501798440620547 120 4011080
SGTC_808 0711-0032 135 µM 2.53369238597529 0.00657350406022122 no 88 0.00564338822734887 93 4252555
SGTC_2361 9034121 116 µM 2.51231181772252 0.00695528425066939 no 89 0.00599715279180209 99 6496917
SGTC_451 chloral hydrate 100 µM 2.51184889507446 0.00696376253342286 no 90 0.00600502507102107 195 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3235 9132602 49.47 µM 2.49636231113017 0.00725270311119418 no 91 0.00627371850390101 128 4912240
SGTC_3278 9139605 49.47 µM 2.48889911382323 0.00739568460860815 no 92 0.00640696607383385 91 7958859
SGTC_970 1315-0089 19.5 µM 2.48432297647803 0.00748457862018926 no 93 0.00648990124989232 109 6811083 YLR033W RSC58
SGTC_2318 6029776 164 µM 2.47692515213872 0.00763027703935553 no 94 0.00662598446466263 139 818325
SGTC_1244 0416-0015 52.5 µM 2.467603620419 0.00781741413920418 no 95 0.00680104233706485 145 96201
SGTC_563 tetrahydrosecaminediol 614 µM 2.46402241196173 0.00789037636588814 no 96 0.00686937602272615 123 334274 A psychoactive constituent of the cannabis plant.
SGTC_382 3229-0966 23.2 µM 2.46208406729377 0.0079301167784381 no 97 0.00690661426507054 119 5722370
SGTC_973 1325-0077 65.9 µM 2.44477943308714 0.00829277184161333 no 98 0.00724703762967941 99 2835149
SGTC_1732 st034308 51.822 µM 2.44348541855357 0.00832046689466645 no 99 0.00727307869852634 137 830119
SGTC_1036 k216-0215 33.5 µM 2.43937692644595 0.00840893762801747 no 100 0.00735630664836947 183 622330
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.43030800710941 0.008607152718629 no 101 0.00754299820512086 138 5282309
SGTC_1022 4477-0945 21.3 µM 2.42371567904583 0.00875379921162382 no 102 0.00768131392762315 135 4648966
SGTC_275 trichlorophene 5.69 µM 2.40754529850763 0.00912282143982139 no 103 0.0080300848426466 360 62616
SGTC_1179 1021-1431 9.29 µM 2.40433997143297 0.00919756615137108 no 104 0.00810084902338178 180 2840958
SGTC_3170 9103054 49.47 µM 2.3937082917557 0.00944933632999669 no 105 0.00833950401097129 112 16432970
SGTC_1792 st045773 43.6 µM 2.38324369715164 0.0097030147920326 no 106 0.00858041488352129 150 2919270
SGTC_1203 3992-3522 103 µM 2.38103433713452 0.00975732764665073 no 107 0.0086320513138038 158 5322312
SGTC_953 1188-0045 9.7 µM 2.37993360174207 0.00978448608768735 no 108 0.00865787890926943 147 6144426
SGTC_2053 5265679 138 µM 2.37852459146819 0.00981934693651326 no 109 0.00869103873612456 168 764595
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.377137749998 0.00985376518276323 no 110 0.0087237855417244 175 551469
SGTC_3114 9122766 49.47 µM 2.3735603572818 0.00994303474051748 no 111 0.00880875670143761 145 17176985
SGTC_2129 girgensonine 121.053 µM 2.36493049173924 0.0101612941392892 no 112 0.00901672757631563 168 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_833 3852-0053 558 µM 2.35415445378932 0.0104396918332505 no 113 0.00928244766733303 142 3123681
SGTC_927 2425-1185 123 µM 2.35389106847643 0.0104465787838387 no 114 0.00928902722768941 130 730375
SGTC_2664 lyso-paf C-16 73.48 µM 2.35283757378675 0.0104741649769348 no 115 0.00931538512808383 138 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2932 9016711 44.54 µM 2.3506462844052 0.0105317482130082 no 116 0.00937041976400178 196 7117328
SGTC_2761 levamisole 97.89 µM 2.34782214344921 0.0106063683612962 no 117 0.00944176794029256 117 26879 An alkaline phosphatase inhibitor.
SGTC_3260 9137109 49.47 µM 2.34570560587849 0.0106625935481443 no 118 0.0094955504748262 75 17478346
SGTC_957 1187-1561 14.1 µM 2.34319571801607 0.0107296042412896 no 119 0.0095596752981739 153 1538454
SGTC_2917 7979103 53.79 µM 2.33275673654645 0.0110122606394092 no 120 0.009830458260169 174 2980565
SGTC_119 0121-0043 24.815 µM 2.33135555128751 0.0110506893553006 no 121 0.00986730962559795 317 1092378
SGTC_2164 5685496 200 µM 2.32992453887248 0.0110900564482387 no 122 0.0099050699068767 120 759046
SGTC_968 1309-0633 340 µM 2.32438041611307 0.0112437289010541 no 123 0.0100525571195977 121 3761976
SGTC_2640 pentamidine 10.38 µM 2.32164057280101 0.0113203531661405 no 124 0.0101261486523938 175 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_662 k832-1615 104 µM 2.30399449592062 0.0118248130341163 no 125 0.010611476279725 147 5878478
SGTC_1995 st072814 61.1 µM 2.26960070837955 0.0128643210008792 no 126 0.0116159103065472 149 5769371
SGTC_2130 NSC 7 2.4545 µM 2.2638087497879 0.0130469370175802 no 127 0.0117929400695711 188 21448
SGTC_1679 SEC14.276 6.7 µM 2.26230423112864 0.0130947384019518 no 128 0.0118393065973255 222 1005053 YMR079W SEC14
SGTC_1136 pergolide 1.05886 µM 2.25141591828524 0.013445213721353 no 129 0.0121796034271527 245 47811 A dopamine receptor agonist.
SGTC_94 0334-0113 514.748 µM 2.24297691561216 0.0137223934129084 no 130 0.0124491515748296 162 6795178
SGTC_841 0251-0215 91.2 µM 2.22244627057673 0.0144173883867014 no 131 0.0131265806435632 219 3888614
SGTC_1795 st049545 62.3 µM 2.2219275639889 0.0144353329560597 no 132 0.0131441006340971 122 5291882
SGTC_1178 0988-0033 191 µM 2.21927438706244 0.0145274201870039 no 133 0.0132340315086473 209 5392207
SGTC_3060 1327-0027 12.5 µM 2.21006409923105 0.0148510281531558 no 134 0.0135503570004571 152 16000455 YPR107C YTH1
SGTC_2973 9094665 17.96 µM 2.19786896688923 0.0152890333406477 no 135 0.0139792224762157 210 25237061 YIL048W NEO1
SGTC_2071 5230951 39.92 µM 2.19629002986917 0.0153465463497631 no 136 0.0140355954486078 162 1799272
SGTC_336 4111-0029 111 µM 2.18927838809731 0.0156041960643554 no 137 0.0142883060917524 130 3131175
SGTC_2905 7799065 20.05 µM 2.18499352937599 0.0157634677090634 no 138 0.0144446605143755 134 1296806
SGTC_2185 6113692 200 µM 2.17936773505668 0.0159746986780505 no 139 0.014652180510387 150 874150
SGTC_1081 sertraline 6 µM 2.17916061516361 0.0159825214707493 no 140 0.0146598692980519 202 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_744 1594-0068 283 µM 2.1783050880241 0.0160148690172673 no 141 0.0146916653133916 216 668392
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.17423286032256 0.0161696106017685 no 142 0.0148438258613299 222 6728940
SGTC_1835 st008666 49.2 µM 2.17327660213523 0.0162061328595679 no 143 0.0148797527046174 142 690455
SGTC_874 0599-0792 117 µM 2.17326503016303 0.0162065752589824 no 144 0.0148801879237733 194 765305
SGTC_2070 5230947 200 µM 2.17198663258569 0.0162555124681689 no 145 0.0149283356010852 151 2835538
SGTC_3297 9117502 71.43 µM 2.16874498375334 0.0163801709224259 no 146 0.015051025079677 129 7453720
SGTC_3336 9143619 71.43 µM 2.16860509421222 0.0163855687858772 no 147 0.015056339047949 164 45595730
SGTC_1500 4488-1866 171 µM 2.15680439842889 0.0168464347312253 no 148 0.0155104541374405 173 2900003
SGTC_73 0327-0325 16.231 µM 2.15244820690411 0.0170193413348545 no 149 0.015681035186673 256 53298
SGTC_12 0849-0099 9.267 µM 2.14716465123986 0.0172310908038841 no 150 0.0158900878942337 152 6071388
SGTC_1979 st071809 45.3 µM 2.14372826336422 0.0173700158654586 no 151 0.0160273331003305 154 4976333
SGTC_1473 k844-0725 134 µM 2.1396904300709 0.0175344772711763 no 152 0.0161898964799513 189 54682906
SGTC_1649 st011737 51.3 µM 2.13194637450672 0.0178536148966355 no 153 0.0165056276257257 163 1761035
SGTC_2309 7664088 163.95 µM 2.12684544875267 0.0180665230418726 no 154 0.0167164633235638 234 704922
SGTC_374 0880-0231 82.3 µM 2.12661399410619 0.0180762348719375 no 155 0.0167260843962416 183 6833587
SGTC_938 3126-1755 342 µM 2.11731165956235 0.0184702611714368 no 156 0.0171167030018113 173 1777771
SGTC_1917 st066507 28.5 µM 2.11361208606109 0.0186289875760263 no 157 0.0172742063636481 236 3156428
SGTC_558 k064-0027 21.3 µM 2.10699248150034 0.0189158930546487 no 158 0.0175591156455826 196 5088526
SGTC_1522 st012842 45.6 µM 2.09213681320224 0.0195734722409449 no 159 0.0182131394353975 196 3491067 YOR116C RPO31
SGTC_400 oxethazaine 37.5 µM 2.09114604761837 0.0196180102299407 no 160 0.0182574869926972 188 4621 A local anesthetic.
SGTC_1322 1348-1070 12 µM 2.08074662216035 0.0200907113024621 no 161 0.0187285521161279 128 6758089
SGTC_405 ebelactone b 50 µM 2.0770878061625 0.0202593024039848 no 162 0.0188967279066085 188 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2401 5128683 200 µM 2.06816444878924 0.0206755095577999 no 163 0.019312281009566 211 708373
SGTC_1899 st063254 59.6 µM 2.06327802492284 0.0209064772134291 no 164 0.0195431103386541 161 3093813
SGTC_2807 7945238 51.95 µM 2.0614938756403 0.02099135152613 no 165 0.0196279735755108 234 17148797
SGTC_1140 3229-1848 2.98 µM 2.05477292836287 0.0213136986248512 no 166 0.0199504710787952 158 2849525
SGTC_3118 9124250 49.47 µM 2.04724621857467 0.0216796502300031 no 167 0.0203169577595394 166 1504786
SGTC_1616 st002734 56.1 µM 2.03449318732438 0.0223118235771208 no 168 0.0209509473978075 242 4026101
SGTC_1357 1503-1303 39.5 µM 2.03293898645432 0.0223899186290532 no 169 0.0210293437974975 242 292895
SGTC_2056 5235370 200 µM 2.02892657295173 0.0225925998479745 no 170 0.0212328848659808 231 5511916
SGTC_1359 1582-0056 520 nM 2.02168584000332 0.0229622695533237 no 171 0.0216044088210303 242 3661189
SGTC_1958 st076513 41.9 µM 2.01243929871402 0.0234417396157962 no 172 0.0220868246895277 247 732122 YGL099W LSG1
SGTC_1070 indatraline 8.81 µM 2.00964340381203 0.0235883660903984 no 173 0.0222344719884219 231 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2117 5521686 200 µM 1.99548307092497 0.0243428814439576 no 174 0.0229951093630112 222 803312
SGTC_671 0560-0003 407 µM 1.9840543684349 0.0249665291424331 no 175 0.0236248896607879 197 3238678
SGTC_2340 7987427 183.45 µM 1.98352378299079 0.0249958048677307 no 176 0.023654476598227 228 2239331
SGTC_475 α-linolenic acid 10 µM 1.97955250584059 0.0252158402553142 no 177 0.0238769171100429 241 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1388 3346-4487 254 µM 1.97613138522787 0.025406692499673 no 178 0.0240699492970359 245 3345614
SGTC_875 0709-0210 25.7 µM 1.97451993406907 0.0254970079964274 no 179 0.0241613265380133 253 6251364
SGTC_2856 9022925 19.48 µM 1.97435243936689 0.0255064108215759 no 180 0.0241708410105518 241 4944862
SGTC_2237 6667747 47.222 µM 1.97250428487016 0.0256103555309468 no 181 0.0242760338234335 193 729940 YDL015C TSC13
SGTC_914 3820-6779 408 µM 1.9611438049831 0.0262571151271565 no 182 0.024931124992004 230 2893481
SGTC_2262 9014885 67.46 µM 1.95991458528403 0.0263279070089615 no 183 0.0250028872827378 134 6457424
SGTC_378 3970-0959 8.33 µM 1.95885771976348 0.02638890034313 no 184 0.0250647258541015 221 6615653
SGTC_656 4090-1979 187 µM 1.9507332939314 0.0268617277535581 no 185 0.0255443903184933 254 22330961
SGTC_1339 1486-1321 22.7 µM 1.94697116848655 0.0270830612285637 no 186 0.0257690956625308 243 3469382
SGTC_2307 7538926 6.34 µM 1.94617008949378 0.0271303863374498 no 187 0.0258171557713454 290 96582
SGTC_1696 st025591 34.7925 µM 1.93861223721937 0.0275802850297709 no 188 0.0262742861710615 268 2787147
SGTC_1272 0839-0021 27 µM 1.9355393687666 0.02776497455557 no 189 0.0264620712234111 244 5027250
SGTC_2177 5811945 192 µM 1.93316670520245 0.027908283502622 no 190 0.0266078324347313 236 5343475
SGTC_1380 2291-0730 164 µM 1.9212391808369 0.0286380715114956 no 191 0.0273507803513988 235 2999191
SGTC_982 1491-0518 27.5 µM 1.92054764838713 0.0286808653450378 no 192 0.0273943802943495 213 3091256
SGTC_194 1486-1323 56.904 µM 1.9147837043274 0.0290396260942421 no 193 0.0277600467527198 225 5178754
SGTC_417 st075190 100 µM 1.91234072714114 0.0291928036560532 no 194 0.0279162526021047 257 222757
SGTC_1950 st077106 7.18 µM 1.91008081385474 0.0293350999279241 no 195 0.028061404454067 265 13831864
SGTC_916 4466-0038 42 nM 1.90823358144223 0.0294518389869845 no 196 0.028180516551493 370 5722064 YGL116W CDC20
SGTC_2032 5185112 25.99 µM 1.90265867373305 0.0298064955764992 no 197 0.0285425488545275 202 5718189
SGTC_1941 st076221 61.8 µM 1.90131288119582 0.0298926391342658 no 198 0.0286305214262562 335 2828568
SGTC_842 0271-0008 11.1 µM 1.88936960352162 0.0306662071495013 no 199 0.0294211604605883 258 1221709
SGTC_2870 9038528 12.99 µM 1.88473810729365 0.0309706171763937 no 200 0.0297326023853238 238 6463316
SGTC_2143 5623677 140.463 µM 1.88058905271818 0.0312454376550966 no 201 0.0300139210284648 184 5375313
SGTC_850 0388-0143 75.9 µM 1.87779513435629 0.031431632124197 no 202 0.0302045980763582 233 67273
SGTC_2840 9008771 71.43 µM 1.87133690477183 0.0318655391204806 no 203 0.0306491991676151 183 2992978
SGTC_694 1315-0438 43.2 µM 1.85990313879558 0.0326458657120545 no 204 0.0314496155977247 211 6793154
SGTC_2626 ethyl orsellinate 100 µM 1.85987301249505 0.0326479423881297 no 205 0.0314517471877712 249 75653 A natural product.
SGTC_2017 5132927 60.65 µM 1.85163125498987 0.0332201712366413 no 206 0.0320393958652814 291 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2819 7996655 46.38 µM 1.84846632679423 0.0334420976807904 no 207 0.0322674556620089 230 6456960
SGTC_1480 1070-0044 41.2 µM 1.84426968576312 0.0337382492958923 no 208 0.0325719235298121 271 3124987
SGTC_2316 5844804 197.44 µM 1.84191921446618 0.0339050596707586 no 209 0.0327434837908965 367 776813
SGTC_941 3237-0776 460 µM 1.83091337962363 0.0346951803571622 no 210 0.033556736489546 250 760008
SGTC_3179 9107801 49.47 µM 1.82187237992016 0.0353555005632504 no 211 0.0342371760352232 260 4818259
SGTC_3111 9122088 49.47 µM 1.81421751383804 0.0359226086103908 no 212 0.0348221224208634 179 16876704
SGTC_739 1486-1183 203 µM 1.81352549672211 0.0359742416744509 no 213 0.0348754048854793 280 4346692
SGTC_3298 9116858 71.43 µM 1.80630600742554 0.0365165386905669 no 214 0.0354352769991348 259 2506942
SGTC_1149 3909-7961 23.3 µM 1.79690615422191 0.0372326205189325 no 215 0.0361752597312737 288 735261
SGTC_1071 trifluoperazine 6.31 µM 1.79524825851896 0.0373601016645751 no 216 0.03630707737552 307 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2172 5754775 163.918 µM 1.792495291898 0.037572573887953 no 217 0.0365268313394389 289 2263357
SGTC_300 r073-0011 5.04 µM 1.78762461344048 0.0379509062162767 no 218 0.0369182958450105 324 2735780
SGTC_2638 epoxomicin 18 µM 1.78150613615596 0.0384305605202978 no 219 0.0374149016789929 303 9915668 A protesome inhibitor.
SGTC_1494 4358-1428 177 µM 1.77608353150232 0.0388597820636942 no 220 0.0378595751012692 300 1564571
SGTC_1474 0330-0125 5.35 µM 1.77400151272611 0.0390256163200897 no 221 0.0380314500456972 283 X1474
SGTC_3214 9129694 49.47 µM 1.76988063370589 0.0393555460201443 no 222 0.0383735138121724 291 17158655
SGTC_2257 7960413 200 µM 1.76620359451977 0.0396518532821704 no 223 0.0386808491153001 331 2974689 YIL048W NEO1
SGTC_2295 7971645 200 µM 1.76421720245275 0.0398126761198172 no 224 0.0388477087886345 315 2978226 YKL099C UTP11
SGTC_1410 3909-8106 77.9 µM 1.76320692738536 0.0398946734918944 no 225 0.0389327979232254 241 1039210
SGTC_525 k781-2675 26.7 µM 1.75406899026565 0.0406425918489349 no 226 0.039709343203309 342 3651118 YDL195W SEC31
SGTC_1315 1237-0019 3.69 µM 1.75294649905127 0.0407352448266674 no 227 0.0398055954835009 275 825140
SGTC_1432 4049-0298 68.4 µM 1.7512885947574 0.0408724054763579 no 228 0.0399481056534115 263 741646
SGTC_1428 4049-0204 61.7 µM 1.7500408505565 0.0409758799332008 no 229 0.0400556325133073 295 X1428
SGTC_199 4063-0024 41.6 µM 1.7458683789174 0.0413234439320499 no 230 0.0404169128267525 264 306215
SGTC_3026 9090633 49.47 µM 1.74468936330166 0.041422086961149 no 231 0.0405194779106249 289 25236842
SGTC_894 0960-0238 55.9 µM 1.74014527940742 0.0418040567907528 no 232 0.0409167556297431 279 6741907 YDL195W SEC31
SGTC_2524 avocatin b 10.57 µM 1.73677574794691 0.0420891329861902 no 233 0.0412133806923575 264 6710748
SGTC_273 hydroxyurea 18.1 mM 1.73654884109833 0.042108386644849 no 234 0.0412334181435696 371 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1727 st034309 9.9045 µM 1.73182350470818 0.04251096659652 no 235 0.0416524959190396 400 870305
SGTC_3101 9120531 49.47 µM 1.72628855137132 0.042986474893148 no 236 0.0421477569936734 329 24824904
SGTC_663 1486-0733 13.9 µM 1.72498724001903 0.0430988923352103 no 237 0.0422648860415613 386 722445 YPR165W RHO1
SGTC_3292 9120825 59.784 µM 1.72488198073805 0.0431079958263499 no 238 0.0422743717701165 302 24824900
SGTC_1620 st003704 16.5 µM 1.72129794563161 0.0434188939075329 no 239 0.0425983860470468 274 2834414
SGTC_1153 4055-0057 267 µM 1.71097110624212 0.0443248304444991 no 240 0.0435432234056005 336 882706
SGTC_372 0155-0182 15.9 µM 1.70249397706317 0.0450798305603499 no 241 0.0443314032883682 333 771486
SGTC_717 1532-0246 73.2 µM 1.70008012518508 0.0452966987269472 no 242 0.044557927572026 341 9561992
SGTC_3340 9146634 11.102 µM 1.69184437586588 0.0460429482347619 no 243 0.0453378250108208 307 4907387
SGTC_1392 3455-1037 33.9 µM 1.68442605155681 0.0467235548061117 no 244 0.0460496797942462 321 981132
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.68349479330892 0.0468095619696794 no 245 0.046139673236823 218 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2747 doxorubicin 7.63 µM 1.67942044809136 0.047187345977283 no 246 0.0465350654415155 191 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3177 9107506 49.47 µM 1.67304947684725 0.047782973947451 no 247 0.0471587781824673 257 8897194
SGTC_2630 antimycin a 100 µM 1.67155757789763 0.0479233192645574 no 248 0.0473057979631097 381 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_925 2064-1272 59.6 µM 1.66773371879087 0.0482845428365285 no 249 0.0476842993319888 323 6815817
SGTC_2099 5377090 177.372 µM 1.66701296951461 0.0483528722707214 no 250 0.0477559129966727 358 2243829
SGTC_432 NS 1619 61.3 µM 1.66354541431737 0.0486826898881824 no 251 0.0481016540285864 318 4552 A K+/calcium channel activator.
SGTC_1158 4092-0494 91.8 µM 1.65331382944804 0.0496663612018797 no 252 0.0491335049369848 354 1148199
SGTC_2473 5854593 8.94 µM 1.65181499806976 0.0498117824126494 no 253 0.0492861351458418 302 2872951
SGTC_57 miconazole 162.5 nM 1.65107052599003 0.0498841395185907 no 254 0.0493620874265705 320 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1737 st035557 69.7 µM 1.64886585779954 0.0500989085579795 no 255 0.0495875595645191 290 5716916
SGTC_3002 9075603 71.4286 µM 1.64808873585712 0.050174787838565 no 256 0.0496672317144956 353 20105405
SGTC_2977 9011197 71.43 µM 1.6458027262603 0.0503985282635737 no 257 0.0499021904162695 278 2704722
SGTC_1418 3966-3099 2.4 µM 1.63923786989448 0.0510454775312835 no 258 0.0505818648833168 374 740335
SGTC_2275 7947463 200 µM 1.63894466131611 0.0510745259458499 no 259 0.0506123926182245 329 1225414
SGTC_600 1495-0418 41.6 µM 1.6366699935861 0.051300326295097 no 260 0.0508497209803815 329 5377768
SGTC_2483 5729050 27.16 µM 1.63587609581102 0.0513793211563796 no 261 0.0509327609022599 439 2865180
SGTC_1936 st074407 74.3 µM 1.63340900808451 0.0516254203419268 no 262 0.0511915018683762 409 809813
SGTC_1848 st056003 16.4 µM 1.63250228950855 0.0517161033264222 no 263 0.0512868582797595 351 146492
SGTC_668 1682-0499 62.6 µM 1.62896413784974 0.0520711735589248 no 264 0.05166030549304 423 682214
SGTC_1255 0566-0045 221 µM 1.62818580573486 0.0521495421372751 no 265 0.051742746799648 376 2788469
SGTC_140 0062-0056 502.533 µM 1.62620687285419 0.0523492185438448 no 266 0.051952827301961 399 3758964
SGTC_4 0960-0234 25.671 µM 1.62513277366982 0.0524578501646363 no 267 0.0520671354643098 334 6821112
SGTC_1154 4088-0362 150 µM 1.62384288413462 0.0525885426695022 no 268 0.0522046724804755 420 6618304
SGTC_887 0885-0007 9.62 µM 1.62076242136792 0.0529017028321923 no 269 0.0525343003259372 397 5719458
SGTC_1270 0831-1170 17.3 µM 1.61893832473097 0.053087836831446 no 270 0.052730266923952 379 6764716
SGTC_1807 st050092 58.9 µM 1.61742723418783 0.0532424240955806 no 271 0.0528930454840313 337 5008496
SGTC_2518 prenyletin 46.28 µM 1.61431327805259 0.0535621125900801 no 272 0.0532297457248447 261 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3335 9143315 29.6265 µM 1.60651185223998 0.0543697102940312 no 273 0.0540807464537189 350 4899691
SGTC_1978 st071761 42 µM 1.60454176996831 0.0545751676340755 no 274 0.0542973425116167 333 5147680
SGTC_116 0155-0182 31.788 µM 1.59863189272158 0.0551951860594532 no 275 0.0549512094646257 530 771486
SGTC_2665 lovastatin 100 µM 1.59796175864879 0.0552658411516007 no 276 0.0550257440257404 346 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2964 9083345 53.42 µM 1.58790440450641 0.0563348339437158 no 277 0.0561539786905182 348 17741579
SGTC_2474 5321570 43.32 µM 1.58759559400154 0.0563679134232992 no 278 0.0561889075804559 338 2841384
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.57802016946525 0.0574012413914389 no 279 0.0572804881331886 371 75037 A free radical scavenger.
SGTC_892 0929-0076 29 µM 1.57778383646614 0.0574269323734194 no 280 0.0573076391888565 443 5751038
SGTC_726 3448-4391 34.2 µM 1.57563522559783 0.0576609159544217 no 281 0.0575549465857176 402 1356692
SGTC_3319 9138450 16.7555 µM 1.5731247378315 0.0579352569347534 no 282 0.0578449689488197 357 2029690
SGTC_598 3937-0236 20.2 µM 1.56900415389949 0.0583877686733594 no 283 0.0583234855585482 440 1379313
SGTC_998 3996-0085 177 µM 1.5683626073308 0.0584584706976066 no 284 0.0583982662332799 430 715391
SGTC_2913 7966556 36.57 µM 1.56759515495712 0.058543136542485 no 285 0.0584878217776645 344 2976516
SGTC_269 exalamide 29 µM 1.56174252009009 0.059191973435593 no 286 0.0591743288255533 348 3316 A derivative of salicylamide.
SGTC_2418 pentamidine 31.67 µM 1.56128970566687 0.0592424076257456 no 287 0.0592277056991519 388 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2648 atorvastatin 78.68 µM 1.55742455044302 0.0596742787562111 no 288 0.0596848605397257 346 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_246 cycloheximide 667 µM 1.55672106914055 0.0597531465729239 no 289 0.0597683620673846 329 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.55467367678408 0.0599831460031889 no 290 0.0600119034306861 291 4620898
SGTC_1169 aniline yellow 25.8 µM 1.55401145387022 0.060057686837328 no 291 0.0600908422658861 340 6051 A DNA damaging agent.
SGTC_2124 5246320 200 µM 1.55224464125429 0.0602569169255922 no 292 0.0603018491385193 385 579342
SGTC_1509 1326-1131 80 µM 1.5516966246396 0.0603188176153072 no 293 0.060367415361314 344 768313
SGTC_655 k060-0012 42 µM 1.5512748034896 0.060366497906556 no 294 0.0604179211989211 387 5994525
SGTC_1186 1319-0216 26 µM 1.55020610321325 0.060487429808735 no 295 0.0605460277119513 426 4565136
SGTC_1482 3346-2049 8.48 µM 1.54275022612348 0.0613364029132551 no 296 0.0614456951706022 379 3826804
SGTC_2928 9011484 9.79 µM 1.54106932668509 0.0615290806214434 no 297 0.0616499570838441 361 2994751
SGTC_3202 9113761 49.47 µM 1.5375703156307 0.0619316802307724 no 298 0.0620768550635061 489 4798415
SGTC_589 1227-0070 34.1 µM 1.53592043959899 0.0621222284242372 no 299 0.0622789472324418 388 2841384
SGTC_2413 inermin 26.06 µM 1.52553856958337 0.0633317684932245 no 300 0.0635624105074448 451 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2475 5812728 15.03 µM 1.52331319895639 0.063593405894688 no 301 0.0638401832638197 436 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2378 9074213 121.43 µM 1.51934753661144 0.0640617337628618 no 302 0.0643375200586396 442 657714
SGTC_1414 3917-0015 5.4 µM 1.51757923433821 0.0642714252419498 no 303 0.06456025251591 364 6618702
SGTC_1898 st060199 18.6 µM 1.51362446929801 0.0647423254989249 no 304 0.0650605557063723 382 688866
SGTC_1876 myriocin 605 nM 1.50961961647478 0.0652219156916378 no 305 0.0655702564803507 403 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1698 5-fluorocytosine 1.055 µM 1.50585040874324 0.0656758004684947 no 306 0.0660527897610576 380 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_899 1083-0020 478 µM 1.49498362675961 0.0669980804972912 no 307 0.0674593576577803 443 767123
SGTC_814 3342-0569 96 µM 1.4883180221773 0.0678192890524819 no 308 0.0683335221656743 468 4346283
SGTC_552 k242-0005 476 µM 1.48169535386397 0.0686428856085883 no 309 0.0692106869531884 384 4088318
SGTC_1933 st074711 15.9 µM 1.48081414151679 0.0687530523922512 no 310 0.0693280535471785 471 17250958
SGTC_1313 1220-0047 237 µM 1.47718925010001 0.0692076608633669 no 311 0.0698124572819081 487 3528706
SGTC_185 k048-0037 25.491 µM 1.47376852178753 0.069638785303962 no 312 0.0702719632056778 436 6827589
SGTC_2843 9000894 45.46 µM 1.47265022753346 0.0697801747772897 no 313 0.07042268691375 289 2242070
SGTC_1967 st070177 51.4 µM 1.47183855602637 0.0698829352781501 no 314 0.0705322395833652 390 5729214
SGTC_2701 st077767 14.721 µM 1.47053688707674 0.0700479742767897 no 315 0.070708201470367 494 5721188
SGTC_918 glabranin 770.725 nM 1.4642761637228 0.0708459657696777 no 316 0.071559253617434 466 124049 Also referred to as licorice root.
SGTC_944 3370-0224 231 µM 1.46114534998046 0.0712476297444351 no 317 0.0719877784910271 443 4580514
SGTC_2113 5491891 107.031 µM 1.45569546458135 0.0719509835270755 no 318 0.0727384121129281 461 789979
SGTC_1332 1480-0653 17.5 µM 1.44945958160198 0.0727622944408152 no 319 0.0736046399797572 474 5749438
SGTC_1730 st033808 45.1 µM 1.44871882896361 0.0728591326547574 no 320 0.0737080599912097 514 1045166
SGTC_2827 7993847 71.43 µM 1.44650118008987 0.0731496346318881 no 321 0.07401834063065 390 2985692
SGTC_2980 9014342 25.29 µM 1.44531683751301 0.0733051407764099 no 322 0.0741844552805208 447 2996599
SGTC_1560 lithocholic acid 53.1 µM 1.44449248670712 0.0734135285840525 no 323 0.0743002458276632 333 9903 A bile acid which acts as a detergent.
SGTC_1162 k048-0130 20.1 µM 1.44379496833383 0.0735053358277169 no 324 0.0743983288994521 443 6797406
SGTC_1886 st057356 49.9 µM 1.43899341691703 0.0741396991000069 no 325 0.0750761939646259 426 24207747
SGTC_2064 5220758 200 µM 1.4387296223903 0.0741746714681958 no 326 0.0751135715321542 505 788518
SGTC_653 0203-0016 55.2 µM 1.43646671964218 0.0744751919995818 no 327 0.0754347898833525 462 295302
SGTC_1201 1889-3372 45.9 µM 1.43528272446212 0.0746328001903277 no 328 0.0756032742834768 421 5392199
SGTC_2256 7954252 200 µM 1.42424695502949 0.0761140988859544 no 329 0.077187498415764 367 2972920
SGTC_2585 alliin 100 µM 1.42414865262079 0.0761273935673871 no 330 0.0772017225526929 501 87310 A garlic compound which reacts with lipids.
SGTC_2431 5490079 200 µM 1.42174898784603 0.0764524791785396 no 331 0.0775495666452763 473 5722345
SGTC_2384 9036245 200 µM 1.42166046162798 0.0764644921048136 no 332 0.0775624217123988 476 6462766
SGTC_838 0109-0203 71.4 µM 1.42103593631076 0.076549280417911 no 333 0.0776531562433476 475 759422
SGTC_2946 9065502 71.43 µM 1.41903640942622 0.0768212260581076 no 334 0.0779442007338565 307 16489101
SGTC_765 1319-0117 244 µM 1.41802320242139 0.0769593073665149 no 335 0.0780919954025268 416 3487746 YGL099W LSG1
SGTC_857 0438-0306 1.35 µM 1.41261141349967 0.0777000304110033 no 336 0.0788850056440332 467 4686136
SGTC_11 0438-0307 1.3 µM 1.40352405562273 0.0789559922758064 no 337 0.0802303118891946 450 4011476
SGTC_2391 6285546 200 µM 1.40194747352002 0.0791754480659908 no 338 0.0804654662871885 502 846083
SGTC_3065 9113888 49.47 µM 1.40106702589172 0.0792982047133653 no 339 0.0805970154520621 436 16648368
SGTC_1082 camptothecin 424.86 nM 1.39423471724129 0.0802557029269367 no 340 0.0816233686904919 428 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1221 2958-7315 257 µM 1.39371593528363 0.0803287618138434 no 341 0.0817017011090197 485 4562705
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.39354181384731 0.0803532942023972 no 342 0.0817280049168642 438 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1030 k029-0042 36.7 µM 1.39130514836887 0.0806689270116378 no 343 0.0820664566518356 529 6080581
SGTC_1919 st067113 52.3 µM 1.38845860202305 0.0810719777248838 no 344 0.0824987211641219 510 1268243
SGTC_338 4055-0136 114 µM 1.3881942692103 0.0811094823502733 no 345 0.0825389484406891 487 2900563
SGTC_2557 derrustone 83.84 µM 1.38504745584626 0.0815569713847497 no 346 0.0830189785014965 537 629853 An antioxidant.
SGTC_786 4544-0069 423 µM 1.38428390900174 0.0816658308335168 no 347 0.083135769551501 514 748821 YLR208W SEC13
SGTC_1108 betulinic acid 729.144 nM 1.38317848025174 0.0818236266923096 no 348 0.08330507323593 495 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.3815082093774 0.0820624874483498 no 349 0.0835613777136038 546 4114 Related to psoralen; DNA damaging agent.
SGTC_1124 fisetin 1.16336 µM 1.37933220317482 0.0823744595154678 no 350 0.0838961759700764 450 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1104 tacrolimus 29.8 µM 1.37431325163385 0.0830974263100166 no 351 0.0846722270401588 526 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3304 9125678 46.087 µM 1.3736769428092 0.0831894247130358 no 352 0.0847709990473933 522 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_550 4123-0385 25.7 µM 1.37079753772599 0.0836066906330796 no 353 0.0852190393697019 488 5731123
SGTC_2491 paeonol 100 µM 1.36418995428041 0.0845701636590352 no 354 0.0862538945279452 433 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2173 5763948 167 µM 1.36312351843916 0.084726441549358 no 355 0.086421792928539 531 2867177
SGTC_690 glyoxal 20.3 µM 1.36277929859208 0.08477693049877 no 356 0.0864760386294634 537 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2329 6138490 200 µM 1.35750214986799 0.0855537905412035 no 357 0.0873108554086705 457 720019
SGTC_1453 4237-0541 195 µM 1.35421563424765 0.0860402918580239 no 358 0.0878337962675233 500 739892
SGTC_520 3584-0023 682 µM 1.35418144681953 0.0860453634617134 no 359 0.0878392483225184 494 1340790
SGTC_2504 purpurogallin 52.29 µM 1.3499074791224 0.0866811571968254 no 360 0.0885228311703251 479 5281571 An antioxidant.
SGTC_1723 st034307 2.5525 µM 1.34947143069315 0.0867462204518485 no 361 0.0885927953907362 504 867466
SGTC_2346 9031566 143.75 µM 1.34773025308317 0.0870063872746336 no 362 0.0888725789790588 489 4771086
SGTC_1102 cgs 12066b 26.1 µM 1.34489419257625 0.0874313986652665 no 363 0.0893297029663915 472 6438352 A 5-HT1B full agonist.
SGTC_2276 7947513 42.08 µM 1.3425329248918 0.0877864383191825 no 364 0.0897116311149784 477 2105100
SGTC_2860 9025725 38.96 µM 1.33794140170069 0.0884798956359133 no 365 0.0904577697622616 462 40546248
SGTC_2341 7987486 176.74 µM 1.33783884551607 0.0884954311503142 no 366 0.0904744879508999 558 1258686
SGTC_3326 9140064 16.379 µM 1.33735530453429 0.0885687067495395 no 367 0.0905533432549621 485 1868434
SGTC_3293 9120939 62.045 µM 1.33508116507966 0.088913935117122 no 368 0.0909248916216551 499 934087
SGTC_2467 5474540 200 µM 1.33475039423432 0.0889642315060722 no 369 0.0909790269626886 523 5413519
SGTC_61 0978-8327 98.565 µM 1.33183920431056 0.0894078153582351 no 370 0.0914565161024103 539 6150059 YHR072W ERG7
SGTC_370 0180-0345 38.7 µM 1.33123969821965 0.0894993672368708 no 371 0.0915550764432154 470 3989527
SGTC_1896 st058441 89 µM 1.32990505428293 0.0897034339672204 no 372 0.0917747779682817 485 688759
SGTC_819 1013-0258 27.7 µM 1.32970678871328 0.0897337782114895 no 373 0.0918074486132226 530 5753198
SGTC_2616 abietic acid 100 µM 1.32359350304788 0.0906731562119975 no 374 0.0928190420281421 561 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1248 0469-0687 58.6 µM 1.32298956281279 0.0907663533831365 no 375 0.0929194243868918 540 4017482
SGTC_1429 4049-0205 9.46 µM 1.31745962057382 0.0916230151207087 no 376 0.0938423037975906 559 22774478
SGTC_1705 st027868 56.3335 µM 1.31501081607878 0.0920042757213023 no 377 0.0942531337131418 512 292948
SGTC_1650 st011916 45.8 µM 1.31304376674954 0.0923113804842355 no 378 0.0945841003645102 495 242528
SGTC_1195 1502-0147 41.1 µM 1.30809524793037 0.0930873198339673 no 379 0.0954205025366166 569 817940
SGTC_3069 9117009 49.47 µM 1.30545064542932 0.0935039710882717 no 380 0.0958697212834287 420 41904981
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.3045099230653 0.0936525114279802 no 381 0.0960298892049003 455 77254
SGTC_2065 5221596 34.26 µM 1.3042475145821 0.093693976867616 no 382 0.0960746020996686 542 788581
SGTC_340 k038-0059 454 µM 1.30322358345486 0.0938559067439457 no 383 0.0962492204699253 549 23733424
SGTC_1053 3366-3204 134 µM 1.30255305001917 0.0939620603140809 no 384 0.09636369771442 577 3632071 YPR165W RHO1
SGTC_597 k018-0003 82.8 µM 1.30123242317237 0.0941713905995768 no 385 0.0965894551107877 592 6786234
SGTC_20 0481-0013 4.944 µM 1.30056311418128 0.0942776128836514 no 386 0.0967040198190507 544 182045
SGTC_2074 5212007 75.395 µM 1.29624945726256 0.0949643300747801 no 387 0.0974447777207225 463 758611
SGTC_623 k072-0108 16.9 µM 1.28899239101929 0.0961279290609835 no 388 0.0987003659364959 559 5382803
SGTC_1834 st055981 52.8 µM 1.28668152188309 0.0965006455158368 no 389 0.0991026580930706 565 471719 YDL150W RPC53
SGTC_1369 1866-0067 208 µM 1.28626848952815 0.0965673745510386 no 390 0.0991746877857586 618 3531355
SGTC_2179 6298986 200 µM 1.28527312241764 0.0967283241879685 no 391 0.099348429506936 516 738374
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.28298439511573 0.0970991557278766 no 392 0.099748771615345 572 4213774
SGTC_868 0527-0199 213 µM 1.28096543341929 0.0974271437141275 no 393 0.100102903848106 581 2849450
SGTC_2375 9072683 200 µM 1.27948179850799 0.0976686833416922 no 394 0.100363722579103 618 16798029
SGTC_746 1095-0025 46.6 µM 1.27486003840559 0.0984239317818657 no 395 0.101179392804015 595 6749286
SGTC_1644 st010134 20.9 µM 1.27463763152943 0.0984603831551068 no 396 0.101218765699663 526 3818134
SGTC_1128 3448-9350 235 µM 1.27285325556157 0.0987531912779753 no 397 0.10153505960362 508 619386
SGTC_1446 4239-0190 62 µM 1.27110749941919 0.0990402782819594 no 398 0.10184520387014 621 1340085
SGTC_1483 3453-0561 55.9 µM 1.26730095009785 0.0996683754876523 no 399 0.102523850470514 626 4546991
SGTC_896 0964-0007 44.5 µM 1.26618083696746 0.0998537520643927 no 400 0.102724173301713 582 6756758
SGTC_780 0109-0199 192 µM 1.26615652826647 0.0998577778979776 no 401 0.102728523860319 613 610414
SGTC_2437 5741531 144.16 µM 1.26423873130088 0.100175763482029 no 402 0.103072176517626 607 2262990
SGTC_1127 asiatic acid 681.4 nM 1.26339723133358 0.100315523786471 no 403 0.103223229328149 562 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_593 1203-0218 61.7 µM 1.25952125972758 0.100961101008766 no 404 0.103921058107051 592 3666956
SGTC_1472 k841-0093 193 µM 1.25628569253771 0.101502328412791 no 405 0.104506203682919 619 X1472
SGTC_3018 9082602 49.47 µM 1.25313479222799 0.102031421154777 no 406 0.105078328003702 612 17332089
SGTC_2347 9049783 174.81 µM 1.25287354492159 0.102075379193666 no 407 0.10512586552104 629 6467988 YPL169C MEX67
SGTC_2796 7949634 45.45 µM 1.24651400457386 0.103149703080157 no 408 0.106287875505011 558 2971588
SGTC_3249 9135183 49.47 µM 1.24284158022639 0.103773817418987 no 409 0.1069631084129 626 4902779
SGTC_685 1278-0033 54.9 µM 1.24125148673549 0.10404489583249 no 410 0.10725643007247 617 3590572
SGTC_969 1313-0238 134 µM 1.24065670456136 0.104146425858817 no 411 0.107366297362771 632 5212874
SGTC_2659 sanguinarine 24.21 µM 1.24062115971602 0.104152495679936 no 412 0.107372865722463 589 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1222 0366-0074 1.18 µM 1.23943309623516 0.104355523090029 no 413 0.107592575568217 611 286520
SGTC_2780 5215298 71.43 µM 1.23918845894759 0.104397364584809 no 414 0.107637856794741 631 2834131
SGTC_2198 6589944 200 µM 1.2375157260022 0.104683785938361 no 415 0.107947839850948 485 5290268
SGTC_1766 st045414 44.774 µM 1.23729108595705 0.104722294265027 no 416 0.107989518008638 618 253960
SGTC_2825 7998094 58.44 µM 1.23540326222879 0.105046314883699 no 417 0.108340229651639 571 2987815
SGTC_512 prima-1 270 µM 1.23532954565331 0.105058982088667 no 418 0.108353941003183 615 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2199 6590217 200 µM 1.23006597518615 0.105966315924251 no 419 0.109336200035335 521 703109
SGTC_385 1494-0393 12.4 µM 1.22917928560029 0.10611971903466 no 420 0.109502296800045 607 3090647
SGTC_2397 5161689 200 µM 1.22911935086454 0.10613009392257 no 421 0.109513530449351 629 2259942
SGTC_3076 9116187 49.47 µM 1.22445362706808 0.106939995355145 no 422 0.110390574864935 548 27241210
SGTC_791 1348-1292 225 µM 1.22359052442722 0.107090304746227 no 423 0.110553367966708 689 5437054
SGTC_2863 9028737 58.44 µM 1.22300365680845 0.107192594773129 no 424 0.110664157561565 557 6460917
SGTC_1631 benzylvanillin 81.9 µM 1.21814253099975 0.10804259029139 no 425 0.111584907002574 626 75506
SGTC_1266 0828-0227 32.9 µM 1.21348767634609 0.108861056297702 no 426 0.112471711616736 565 3913820
SGTC_173 1273-0061 2.693 µM 1.2127959415929 0.108983063883593 no 427 0.112603923727068 639 2847414 YPL266W DIM1
SGTC_457 grayanotoxin iii 135 µM 1.21243914209689 0.109046034285222 no 428 0.112672162628609 670 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2497 7-hydroxyflavone 100 µM 1.20891657996083 0.109669123878405 no 429 0.113347447848343 544 5281894
SGTC_89 0302-0250 142.109 µM 1.20807723764749 0.109817967577364 no 430 0.113508777164176 674 4203518 YLR208W SEC13
SGTC_62 0180-0423 3.232 µM 1.20697479537653 0.11001368798521 no 431 0.113720925386807 595 30102 YGL099W LSG1
SGTC_3075 9116269 49.47 µM 1.20433937508967 0.110482577260064 no 432 0.114229216857572 626 17015205 YNL244C SUI1
SGTC_2453 5731132 22.18 µM 1.2022721380079 0.110851377780623 no 433 0.114629054042386 669 1362040
SGTC_120 rhodamine 6G 52.259 µM 1.19894092577788 0.111447529106015 no 434 0.115275458367633 717 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2670 beta-carotene 100 µM 1.1979610605474 0.111623321006467 no 435 0.115466088321597 527 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_538 2922-0838 53.3 µM 1.19775496793713 0.111660320115729 no 436 0.115506211540374 698 777039
SGTC_2871 9038510 12.99 µM 1.19715205949382 0.111768608603514 no 437 0.115623645879858 670 4945164
SGTC_2477 5967686 25.23 µM 1.19514904226734 0.112128910137147 no 438 0.116014401911245 614 776118
SGTC_3327 9140648 26.9345 µM 1.19493715021097 0.11216707365725 no 439 0.116055793365626 596 8029710
SGTC_427 1354-0053 47.3 µM 1.19145009934139 0.112796454485146 no 440 0.116738467613888 613 6813657
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.19140247345254 0.112805067941453 no 441 0.116747811195657 598 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2686 alizarin 95.37 µM 1.19098477594735 0.112880631412543 no 442 0.116829780746148 587 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1451 4152-0210 104 µM 1.18878695355864 0.113278823239917 no 443 0.117261756599106 649 659563
SGTC_443 clozapine 122 µM 1.18853093482976 0.113325272669229 no 444 0.117312149838477 547 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1622 st003707 19.4 µM 1.18843462329667 0.11334274996861 no 445 0.117331111210961 661 10140899
SGTC_2646 retinol 96.75 µM 1.18677250869332 0.113644670716184 no 446 0.117658682702877 615 445354 A vitamin A analog and teratogen.
SGTC_822 1487-0950 154 µM 1.18278201506749 0.114371877724847 no 447 0.118447775062031 626 1958375
SGTC_2852 9023854 51.95 µM 1.18259574779826 0.114405902860496 no 448 0.118484699276183 639 19798528
SGTC_2466 5983409 37.09 µM 1.18158552989186 0.114590563231876 no 449 0.118685098937653 607 2879657
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.18115243713699 0.114669794318062 no 450 0.118771086017604 646 3256 An antibiotic and ribosome inhibitor.
SGTC_1637 st007924 17.4 µM 1.17959364755181 0.114955285865656 no 451 0.119080935345167 630 683336
SGTC_1652 st011932 78 µM 1.17786105218926 0.115273202668821 no 452 0.119426002208737 616 1551076
SGTC_3001 9076041 71.4286 µM 1.17785620189731 0.115274093533321 no 453 0.119426969191018 618 16004211
SGTC_1041 0206-0046 107 µM 1.17481484012458 0.115833671576301 no 454 0.120034400824475 636 50494
SGTC_902 1120-0002 2.07 µM 1.1745123478627 0.115889432204253 no 455 0.120094934503321 660 3280475
SGTC_1743 st037606 46.3785 µM 1.17004596591547 0.116714972352255 no 456 0.120991235705026 633 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2523 spermine 47.74 µM 1.16993513919249 0.116735509799592 no 457 0.121013535789083 626 1103 A DNA binding polyamine.
SGTC_1812 st052057 4.327 µM 1.16971777829771 0.116775796675817 no 458 0.12105728062534 667 3645418
SGTC_1801 st050089 28.441 µM 1.1694657819104 0.116822515423164 no 459 0.121108009930418 746 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1510 1123-0200 71.5 µM 1.16851251201742 0.116999366286091 no 460 0.121300047635795 728 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1356 1502-0781 85.8 µM 1.16839111982394 0.117021900606323 no 461 0.121324517644089 634 567702
SGTC_2048 5246248 200 µM 1.16833938519973 0.117031505161675 no 462 0.121334947266398 610 677046
SGTC_2555 cholic acid 100 µM 1.16327884690576 0.117973697366503 no 463 0.122358192585965 634 6708657 Influences liver metabolism.
SGTC_2834 9001755 58.44 µM 1.16269567806636 0.118082618021144 no 464 0.122476497881587 586 2989575
SGTC_2756 carbadox 75.1 µM 1.16141854912816 0.118321400625769 no 465 0.122735864595349 664 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1377 2944-0135 198 µM 1.1580226941003 0.118957977804364 no 466 0.123427387677152 658 1894137
SGTC_137 0438-0332 85.389 µM 1.15543151764094 0.119445336332155 no 467 0.123956880730457 768 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3334 9142812 21.919 µM 1.15310667762515 0.119883798777795 no 468 0.124433300565557 655 45283678
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.15256552351686 0.119986022485695 no 469 0.124544380495295 690 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_572 0960-0087 17.7 µM 1.15201590969678 0.12008990710069 no 470 0.124657267844236 701 6796365
SGTC_1103 duloxetine 36.1 µM 1.15025421194449 0.120423319500677 no 471 0.125019591829967 737 60835 A selective serotonin reuptake inhibitor.
SGTC_3210 9128157 49.47 µM 1.15020543464538 0.120432560178241 no 472 0.125029634190164 606 17590849
SGTC_641 4092-0595 30 µM 1.14783435689226 0.120882354329658 no 473 0.125518475570026 688 786260
SGTC_2273 7815444 169.05 µM 1.14712546978156 0.121017059691039 no 474 0.125664884366986 644 2824616
SGTC_3133 9127736 49.47 µM 1.14524108276388 0.121375651304669 no 475 0.126054652222353 685 27243420
SGTC_743 1275-0778 158 µM 1.14509320302529 0.121403823833085 no 476 0.126085275393238 712 2849257 YMR203W TOM40
SGTC_80 0159-0065 512.242 µM 1.14282707263771 0.121836118830097 no 477 0.126555198047214 557 1548079
SGTC_2644 guaiazulene 100 µM 1.1425448450577 0.121890033187517 no 478 0.126613808299461 660 3515 A coloring agent.
SGTC_2002 4023503 131 µM 1.14148378544775 0.122092878931365 no 479 0.126834327871444 786 4736863 YCR052W RSC6
SGTC_504 lovastatin 124 µM 1.13824054732118 0.122714367040032 no 480 0.127510025884692 591 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_725 1497-0963 19 µM 1.13777460747991 0.122803835104955 no 481 0.127607305296922 690 3549977
SGTC_142 0335-0849 62.6745 µM 1.13652624669521 0.123043766213801 no 482 0.127868193646491 780 3889043 YPR107C YTH1
SGTC_710 3448-4187 58 µM 1.13316360505078 0.123691689701981 no 483 0.128572777427762 769 3946412
SGTC_697 0508-1955 564 µM 1.13279489262268 0.123762879338519 no 484 0.128650198383647 729 6243113
SGTC_844 0330-0132 15.3 µM 1.13245538736404 0.123828455124117 no 485 0.12872151512137 702 2828079
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.1320714589615 0.123902640584384 no 486 0.128802196461411 746 91467 include heat shock
SGTC_3343 9148379 18.9835 µM 1.13063974378978 0.124179561356568 no 487 0.129103376182812 680 1955036
SGTC_1647 st011722 22.4 µM 1.13001822075257 0.124299910333054 no 488 0.129234273430228 643 2854783
SGTC_2008 4012253 172 µM 1.12791104964988 0.124708540668207 no 489 0.129678743430229 697 603940
SGTC_409 arachidonic acid 100 µM 1.12619653100449 0.125041718430315 no 490 0.130041170774176 681 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1275 0867-0008 21.1 µM 1.12608017238338 0.125064352593828 no 491 0.130065792880161 685 3422836
SGTC_439 amiodarone 34.4 µM 1.12051042973814 0.126151131177963 no 492 0.131248155299856 712 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2206 7254556 146.969 µM 1.11450470053033 0.127330337314654 no 493 0.132531364519868 648 4398905
SGTC_2890 9046729 58.44 µM 1.11333847293119 0.127560208562514 no 494 0.132781544448652 623 903329
SGTC_3032 9089427 49.47 µM 1.11266954135011 0.127692189581816 no 495 0.132925190787109 659 17173707
SGTC_3009 9080819 71.4286 µM 1.1114062324605 0.127941700808912 no 496 0.133196765425339 690 17027216
SGTC_3204 9114183 49.47 µM 1.11134350398099 0.127954098888617 no 497 0.133210260165355 661 17027248
SGTC_1985 st071382 65.5 µM 1.11089037603775 0.128043682944595 no 498 0.13330776925128 696 6123237
SGTC_2769 toremifene 3.73 µM 1.11009648477201 0.128200741426293 no 499 0.133478725924325 658 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2253 7938677 135.83 µM 1.10855689625514 0.128505705176512 no 500 0.13381069077747 681 2301972
SGTC_1362 1611-0397 101 µM 1.10829474369441 0.128557682832543 no 501 0.133867272397354 704 27816
SGTC_3185 9108267 49.47 µM 1.09901965632986 0.130406073916825 no 502 0.13587974611093 698 4910486
SGTC_190 3970-0790 3.722 µM 1.09864363106645 0.13048139608942 no 503 0.135961769325235 677 2832352
SGTC_1738 st035555 74 µM 1.09760503961104 0.130689594168443 no 504 0.13618849564549 706 5331140
SGTC_696 1560-0013 611 µM 1.09578499996079 0.131054996510749 no 505 0.136586437172427 708 1650269
SGTC_365 0121-0052 13.6 µM 1.09093765066821 0.132031621098295 no 506 0.137650159282666 774 3101739
SGTC_2428 5615643 7.78 µM 1.08947705980206 0.132326876608259 no 507 0.137971782838548 684 2253075
SGTC_1449 4112-4002 201 µM 1.08746305477155 0.132734749591839 no 508 0.138416108842553 678 2059539
SGTC_782 0083-0095 30.5 µM 1.08541223126555 0.133150967901121 no 509 0.138869558758274 770 3591729 An indicator and reagent.
SGTC_2166 5933061 31.504 µM 1.08452301298963 0.133331715210059 no 510 0.13906648452463 686 2877375
SGTC_1229 0139-0193 12.2 µM 1.0754744809115 0.135180568004663 no 511 0.141081175720505 777 3090752
SGTC_3300 9124615 50.48 µM 1.07462272922382 0.135355504058483 no 512 0.141271835724465 716 24824903
SGTC_642 0335-0876 158 µM 1.07455457725388 0.135369508074856 no 513 0.141287098717516 741 6812350
SGTC_3262 9137218 49.47 µM 1.07429674828676 0.135422496321516 no 514 0.141344850987849 575 17650664
SGTC_1114 scopoletin 1.73284 µM 1.0742806710012 0.135425800948446 no 515 0.141348452741284 735 5280460 A coumarin with genotoxic properties.
SGTC_1468 k284-1086 134 µM 1.06826890725273 0.136665372224181 no 516 0.142699614827339 785 15996457
SGTC_1752 st044819 83.042 µM 1.06807259306714 0.136705980813733 no 517 0.14274388377408 693 441209 YML126C ERG13
SGTC_870 0573-2213 57.6 µM 1.06719446874057 0.136887726281961 no 518 0.142942014883186 716 3916321
SGTC_2093 5331342 194.4 µM 1.06341303251755 0.137672256746257 no 519 0.143797342588207 764 33839
SGTC_880 0833-0487 87.2 µM 1.06208895181435 0.137947686272873 no 520 0.144097652604672 716 76075
SGTC_490 phenamil 164 µM 1.06127987854289 0.138116171071133 no 521 0.14428136363852 642 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_83 0170-0301 39.027 µM 1.06001230376723 0.138380418175476 no 522 0.144569500948751 670 3089716
SGTC_1007 4101-0031 70 µM 1.05667042425994 0.13907873965322 no 523 0.145331013729403 777 1146276
SGTC_1846 st056244 14.8 µM 1.05345371991527 0.139753166437694 no 524 0.146066547273768 787 5393182
SGTC_1552 6-methylflavone 10.6 µM 1.05112389290984 0.14024303320873 no 525 0.146600845907703 712 689013
SGTC_2087 5276107 200 µM 1.04904447730836 0.140681232620939 no 526 0.147078824172239 753 144405
SGTC_3317 9138495 8.753 µM 1.04772981536236 0.140958752904568 no 527 0.147381553320591 765 17020139
SGTC_2175 5807670 165.306 µM 1.04502489269907 0.14153091945239 no 528 0.148005732399611 751 241186
SGTC_491 tetrandrine 80.3 µM 1.04156911491093 0.142264199394036 no 529 0.148805747035358 726 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1487 3970-0795 2.82 µM 1.03993182224218 0.142612511713002 no 530 0.149185788381392 797 3765103
SGTC_3093 9117344 49.47 µM 1.03967165557792 0.14266791177347 no 531 0.149246236779722 728 24824913
SGTC_2218 6965428 192.983 µM 1.03923558462881 0.142760801638184 no 532 0.149347592317413 758 675684
SGTC_1048 3161-0300 24.5 µM 1.0376583464627 0.143097119105032 no 533 0.14971457183098 783 2165101
SGTC_2525 harmine 47.85 µM 1.03514242397171 0.143634701088485 no 534 0.150301201315097 720 5280953 A monoamine oxidase inhibitor
SGTC_1231 0242-0792 125 µM 1.03342949232394 0.144001485392835 no 535 0.150701475329738 759 3707635
SGTC_2126 5251174 33.877 µM 1.03091612653279 0.144540806473057 no 536 0.151290076730869 856 790722
SGTC_1836 st055642 81 µM 1.02909190756059 0.144933100855749 no 537 0.151718244264049 761 8571
SGTC_350 k064-0020 19.8 µM 1.0257984216777 0.145643171741677 no 538 0.152493305104833 825 2790705
SGTC_341 1486-1430 230 µM 1.02481426208382 0.145855808283225 no 539 0.152725417796648 742 2054753 YPL210C SRP72
SGTC_1276 0871-0068 94.2 µM 1.02382646120955 0.146069441255279 no 540 0.152958624803445 768 3414906
SGTC_518 1021-0119 62.6 µM 1.02150104440385 0.146573191701226 no 541 0.153508557265651 733 1097762
SGTC_2750 bromebric acid 70.15 µM 1.0194655514058 0.147015092423411 no 542 0.153990999755335 831 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2584 androsterone 48.74 µM 1.01853385941558 0.147217658304834 no 543 0.154212159119361 940 2754130 A steroid.
SGTC_296 1222-0039 74.9 µM 1.01799455062716 0.147334998775812 no 544 0.154340272898654 727 5984176
SGTC_1212 0520-0165 585 µM 1.01728915584088 0.147488570101057 no 545 0.154507946899557 756 5403258
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.01623096702163 0.147719149175894 no 546 0.154759706589626 829 4174840
SGTC_1756 st041558 35.5 µM 1.01120511371753 0.148817576100423 no 547 0.155959134395304 874 3955792
SGTC_1476 4112-3294 3.34 µM 1.0108481071311 0.148895808889152 no 548 0.156044567040878 785 704369
SGTC_1868 st057644 42.7 µM 1.00654449574318 0.149841044719599 no 549 0.157076859372354 853 688665
SGTC_429 1112-0049 25.5 µM 1.0064193906971 0.149868582251726 no 550 0.157106934913917 746 2836170
SGTC_1284 0929-0043 16 µM 1.0059315975748 0.149975985206198 no 551 0.157224237674608 803 1239883
SGTC_3124 9127567 49.47 µM 1.00485015631329 0.150214281401507 no 552 0.157484504144781 768 17592030
SGTC_2703 st077852 53.4 µM 1.00423494944502 0.150349955136977 no 553 0.157632689987352 752 6281836
SGTC_3313 9133968 57.047 µM 1.00114712606721 0.151032156794171 no 554 0.158377842210247 841 1494643
SGTC_1306 1185-0270 9.02 µM 1.00065200123913 0.151141737469359 no 555 0.158497540150791 841 1548076
SGTC_1685 st024049 53.0905 µM 0.997939019486173 0.151743111471704 no 556 0.15915446478159 773 1941139
SGTC_2415 st077333 57.7 µM 0.996933484834961 0.15196640699464 no 557 0.159398398513606 892 2766255
SGTC_750 4073-0104 132 µM 0.995927545755056 0.152190010619888 no 558 0.159642675158274 691 22330957
SGTC_1260 0700-1617 7.75 µM 0.992804923349104 0.152885508890041 no 559 0.160402515094233 818 2853078
SGTC_733 4069-0007 56.1 µM 0.989918000077279 0.153530382186834 no 560 0.161107100314141 856 5717425 YNL287W SEC21
SGTC_2566 crystal violet carbinol 226 nM 0.988084852833053 0.153940799530908 no 561 0.161555546697251 679 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1902 st060212 70.5 µM 0.988022098850348 0.153954862155131 no 562 0.161570912718767 832 688944
SGTC_1368 1852-0141 284 µM 0.987815017961347 0.154001273220164 no 563 0.161621625572957 784 2838987
SGTC_951 1171-0579 82.7 µM 0.986179007108397 0.154368262170505 no 564 0.162022639462315 867 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1872 amphotericin b 148 nM 0.985380021490086 0.154547700117758 no 565 0.162218719667692 861 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2212 7123476 200 µM 0.983303036713563 0.155014798670683 no 566 0.162729158000437 741 1085715
SGTC_776 4476-4378 112 µM 0.982375102228124 0.155223785269655 no 567 0.162957543794915 787 2892008
SGTC_2999 9069765 71.4286 µM 0.981987560297769 0.155311121321701 no 568 0.16305298834325 835 2097066
SGTC_147 4466-0538 29.23 µM 0.978954939837001 0.155995669206179 no 569 0.163801122173303 837 6742687 YHR072W ERG7
SGTC_2238 6671620 73.2395 µM 0.978732480914969 0.156045962622846 no 570 0.163856089361365 786 729941
SGTC_1722 st034304 3.6505 µM 0.977761639048101 0.156265575197595 no 571 0.164096113959183 815 4036148 YLR033W RSC58
SGTC_1680 diphenhydramine 100 µM 0.97341798495773 0.157250638337511 no 572 0.16517280193313 800 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2744 captopril 92.04 µM 0.97308917232474 0.157325373035994 no 573 0.165254492479718 777 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3259 9138485 49.47 µM 0.97282133551716 0.157386266000807 no 574 0.165321053449848 898 17646153
SGTC_1664 st014217 9.02 µM 0.972189999534289 0.157529862153994 no 575 0.165478017376282 914 3982782
SGTC_1257 0669-0121 16 µM 0.970917007577261 0.157819663449982 no 576 0.165794804064102 911 4307855
SGTC_304 1310-0298 97 µM 0.970734282261413 0.157861290257854 no 577 0.165840307792672 844 1550234
SGTC_1524 corynanthine 62.1 µM 0.969859871378945 0.158060590336917 no 578 0.166058172364307 822 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_26 0302-0163 425.158 µM 0.967901479256208 0.158507555783005 no 579 0.166546787748948 848 3100915
SGTC_1627 st003713 25.6 µM 0.967337189990931 0.158636497679515 no 580 0.166687748977717 900 16195070 YER133W GLC7
SGTC_522 1273-0010 11.6 µM 0.963968868783203 0.159407599975751 no 581 0.167530766960427 817 5705015
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.962594248657873 0.159722992620714 no 582 0.167875592456256 821 803109
SGTC_755 1995-0008 37.3 µM 0.962353609682942 0.159778246758129 no 583 0.167936004060845 872 689533
SGTC_1354 1498-1681 81 µM 0.961766843294725 0.15991302909753 no 584 0.168083368440208 892 5754243
SGTC_2350 9023895 38.85 µM 0.959956665348905 0.160329301892703 no 585 0.168538512613388 823 2997209
SGTC_1799 st045822 46.1415 µM 0.959853986527687 0.160352935361809 no 586 0.168564353506079 833 3674992
SGTC_1457 k015-0032 57.3 µM 0.958140403968762 0.160747684745143 no 587 0.16899598196454 845 4302660
SGTC_2795 7780010 54.55 µM 0.956122023780401 0.161213462023691 no 588 0.169505294554662 798 953673
SGTC_1101 ebselen 5.29 µM 0.956073751688299 0.161224612441019 no 589 0.169517487450475 915 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3041 9091929 49.47 µM 0.95576707503711 0.161295463729176 no 590 0.169594963084495 872 25236887
SGTC_150 3970-0969 77.2 µM 0.955526130034406 0.161351143325628 no 591 0.169655848883072 882 6615640
SGTC_700 3453-2283 142 µM 0.955501721750975 0.16135678449612 no 592 0.16966201753666 900 565664
SGTC_3096 9117468 49.47 µM 0.953216513790132 0.161885504785703 no 593 0.170240190515384 733 41316311
SGTC_3183 9108214 49.47 µM 0.952339087891471 0.16208881119418 no 594 0.170462520167687 777 4974831
SGTC_3153 9100258 49.47 µM 0.951703349778388 0.162236220503085 no 595 0.170623725026529 777 25236848
SGTC_1762 st045503 25.4615 µM 0.951129509767813 0.16236935235365 no 596 0.170769318088645 866 4645554
SGTC_1187 1391-0724 117 µM 0.950309561992261 0.162559704979961 no 597 0.170977490845343 861 6997986
SGTC_1426 4048-4480 71.7 µM 0.949813656286675 0.162674900982758 no 598 0.171103472806864 871 14224343
SGTC_1034 k072-0165 12.7 µM 0.948915393001428 0.162883697477146 no 599 0.171331822496204 879 5835461
SGTC_1383 3049-0032 20.7 µM 0.947304987139729 0.163258463751405 no 600 0.171741695147083 883 712864
SGTC_1624 st003710 6.25 µM 0.946914351503267 0.163349455053476 no 601 0.171841212134036 907 24207033
SGTC_2265 7929201 200 µM 0.944734915312539 0.163857718673873 no 602 0.172397113467986 911 1265108
SGTC_1281 0884-0031 11.8 µM 0.944321324896397 0.163954287322773 no 603 0.172502735916818 871 1548255
SGTC_2331 7980721 200 µM 0.943118333278774 0.1642353820216 no 604 0.172810189660951 868 2981221
SGTC_3231 9132313 49.47 µM 0.940017186435283 0.16496144579361 no 605 0.173604372546926 866 4905967
SGTC_284 0988-0104 32.6 µM 0.939163720475063 0.165161629820916 no 606 0.173823346330291 884 4666532
SGTC_1817 st052116 64.4 µM 0.936869568507748 0.165700511873003 no 607 0.174412827259602 851 4361398
SGTC_3311 9131146 2.8755 µM 0.934674863966801 0.16621709711758 no 608 0.174977942306055 871 4900406 YPR165W RHO1
SGTC_3031 9088762 49.47 µM 0.931589481651986 0.166945085529645 no 609 0.175774360522348 926 205253
SGTC_95 0471-0001 561.058 µM 0.930659243259249 0.167164975867674 no 610 0.176014929308653 837 4015405
SGTC_1471 k673-0312 37 µM 0.92983140892589 0.167360816814241 no 611 0.176229190616209 894 24099884
SGTC_60 0986-0278 202 µM 0.929778002109105 0.167373456351442 no 612 0.176243019113231 762 3110598
SGTC_202 3594-0513 34.79 µM 0.926976925847384 0.168037235855337 no 613 0.176969257316964 842 708429
SGTC_2739 tacrine 100.86 µM 0.926942068832864 0.168045506685199 no 614 0.176978306630535 831 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2532 xanthone 78.9 µM 0.926888874884157 0.168058128985376 no 615 0.176992117003371 798 7020 An insecticide.
SGTC_1319 1306-0155 43.7 µM 0.923174907281871 0.168940918155706 no 616 0.177958031582436 902 3122360
SGTC_617 3770-0098 35 µM 0.918455834926624 0.170066904047628 no 617 0.17919013536075 857 5962639
SGTC_1787 fluconazole 80 µM 0.917582552965974 0.170275798141047 no 618 0.179418727719439 881 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2469 5655019 90.81 µM 0.915452701437847 0.170785959950048 no 619 0.179977011113008 956 2788239
SGTC_206 4546-0025 72.014 µM 0.915402533204358 0.170797988491175 no 620 0.179990174504869 935 6620745 YIL048W NEO1
SGTC_609 0986-0026 86.3 µM 0.915158161826369 0.170856587725745 no 621 0.180054302532585 891 2848610
SGTC_2221 6807166 181.081 µM 0.913635030557212 0.171222118169752 no 622 0.180454326483957 831 674925
SGTC_2430 5571206 200 µM 0.912785194407003 0.171426284261654 no 623 0.180677763300369 993 1731771
SGTC_1115 galangin 695.678 nM 0.91225522328197 0.171553684172204 no 624 0.180817189778391 981 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2812 7970281 58.44 µM 0.908918073960998 0.172357291826153 no 625 0.181696686283127 907 2233435
SGTC_33 0986-0033 35.816 µM 0.908691497531271 0.17241193984938 no 626 0.181756496752767 870 2848082
SGTC_3 0833-0587 95.581 µM 0.907936785260504 0.172594048791012 no 627 0.181955810609379 891 5382644
SGTC_1781 st038725 66.3 µM 0.906019185331254 0.173057309179326 no 628 0.182462848914344 947 4270275 YIL048W NEO1
SGTC_2459 5811157 9.22 µM 0.902738868165719 0.173851614039554 no 629 0.183332251303543 936 2870684 YBR192W RIM2
SGTC_606 k015-0008 38.6 µM 0.90235115382939 0.173945649217228 no 630 0.183435180005968 985 1970475
SGTC_2508 celastrol 40.54 µM 0.899714665950726 0.174585953269109 no 631 0.18413605827693 859 122724 Celastrol is a natural product and antioxidant.
SGTC_1695 st026914 34.495 µM 0.895605367638812 0.175586928025046 no 632 0.185231783955784 906 3289191
SGTC_537 1334-0398 209 µM 0.89461039062004 0.175829838077436 no 633 0.185497697714573 951 5846986
SGTC_1068 loratadine 26.9 µM 0.893570698019026 0.176083892125732 no 634 0.185775814990208 881 3957 A H1 histamine antagonist.
SGTC_3139 9095020 49.47 µM 0.892526359635419 0.176339315213223 no 635 0.186055435247394 747 25236292
SGTC_2602 kawain 100 µM 0.891434577426587 0.176606592571955 no 636 0.186348037320148 974 5369129
SGTC_176 1486-1328 72.834 µM 0.891052412257804 0.176700210281305 no 637 0.186450526463676 945 22310231
SGTC_272 doxorubicin 8.13 µM 0.89083800157245 0.176752747479213 no 638 0.186508042456885 985 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3194 9111903 49.47 µM 0.887203869132017 0.17764472319808 no 639 0.187484574860103 895 17087251
SGTC_1681 tripelennamine 100 µM 0.886559918032233 0.177803072819004 no 640 0.187657940780535 881 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_182 3448-4371 550.524 µM 0.88550954964846 0.1780615527382 no 641 0.187940935688787 998 3491403
SGTC_2442 5158906 48.48 µM 0.885141010293432 0.178152300866329 no 642 0.188040291607713 935 1893835
SGTC_1508 1080-0625 72.9 µM 0.88420674630448 0.1783824820887 no 643 0.188292308612646 885 767111
SGTC_1436 4092-1007 8.32 µM 0.883954270654475 0.178444718445579 no 644 0.188360449477327 926 2881121
SGTC_621 3584-0052 32.1 µM 0.883268371322559 0.178613864692484 no 645 0.18854564420429 967 2273927
SGTC_1385 3091-4834 14.1 µM 0.883025204274833 0.178673855152143 no 646 0.188611326931582 882 4072814
SGTC_2730 imipramine 71.33 µM 0.882425090873568 0.178821960246419 no 647 0.188773486081497 1023 3696 A tricyclic antidepressant.
SGTC_3351 9150312 21.596 µM 0.882043940127228 0.178916066528383 no 648 0.188876523020171 905 4904905
SGTC_3271 9137798 49.47 µM 0.881106507957217 0.179147651496829 no 649 0.189130087569747 853 6498326
SGTC_1511 0906-3109 28.5 µM 0.877397883254852 0.180065684378608 no 650 0.190135281243089 1037 2882180
SGTC_179 1273-0063 6.77 µM 0.876641915972381 0.180253178265547 no 651 0.190340582327733 894 3108139
SGTC_1546 5-methoxyflavanone 78.7 µM 0.875747852510672 0.180475080639409 no 652 0.19058356241155 971 147795
SGTC_622 1348-1566 26.3 µM 0.874906151719844 0.180684143372082 no 653 0.190812485794512 988 7340407
SGTC_2586 curcumin 80 µM 0.873317949492039 0.181079036487117 no 654 0.191244899804028 1003 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_945 3381-0768 11.3 µM 0.873084632339245 0.181137094350539 no 655 0.191308474779012 990 1126236 YIL048W NEO1
SGTC_2255 7941087 197.44 µM 0.869269462102078 0.182088102316662 no 656 0.192349880946103 1014 935561
SGTC_2330 7979373 200 µM 0.868135811188675 0.1823712881017 no 657 0.19265999430937 916 1863007
SGTC_412 gemfibrozil 100 µM 0.866806253385983 0.182703761786026 no 658 0.193024087604243 927 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_348 k064-0012 10.7 µM 0.866511729906113 0.182777462483927 no 659 0.193104798315017 883 5066323
SGTC_387 norethindrone acetate 66.7 µM 0.86556604451421 0.183014233485376 no 660 0.193364091582353 899 541197
SGTC_3126 9127922 49.47 µM 0.864296882062374 0.183332293958083 no 661 0.193712411272161 935 45595682
SGTC_747 3448-8087 38.7 µM 0.862741288140643 0.183722605838542 no 662 0.194139863071062 945 5168703
SGTC_2400 5203494 178.7 µM 0.859579314518126 0.184517566365549 no 663 0.195010490820527 892 6777674
SGTC_1947 st076332 61.6 µM 0.858627613373933 0.184757254421858 no 664 0.195272999235188 966 24208416
SGTC_124 0136-0217 7.121 µM 0.856819646766529 0.185213127651741 no 665 0.195772282994184 1099 3976905
SGTC_3216 9129716 49.47 µM 0.856400114024024 0.185319011317318 no 666 0.195888250820741 898 8056934
SGTC_2662 daunorubicin 22.37 µM 0.853861574637854 0.185960501389213 no 667 0.196590846200554 930 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.853470692112737 0.186059399765579 no 668 0.196699166827711 871 61125 An anti-inflammatory.
SGTC_1822 st052468 42 µM 0.852665221540104 0.186263297119937 no 669 0.196922491280403 972 2873678
SGTC_5 0352-0601 109.883 µM 0.852621850594556 0.186274279996736 no 670 0.196934520645193 922 762456
SGTC_102 gallobenzophenone 83.616 µM 0.851193504869467 0.186636205893223 no 671 0.197330935119344 954 70837
SGTC_2558 carylophyllene oxide 100 µM 0.847590966571209 0.18755097861591 no 672 0.19833290346498 1057 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_141 0443-0274 32.331 µM 0.844505340698434 0.188336693375501 no 673 0.199193540115595 1120 1627241
SGTC_2174 5790901 200 µM 0.843374890426194 0.188625055422814 no 674 0.199509405238269 943 786020
SGTC_2896 9052656 71.43 µM 0.841983088464162 0.188980458262517 no 675 0.199898709836425 994 6469436
SGTC_561 1550-0330 72.9 µM 0.840566042345266 0.189342730813116 no 676 0.200295544520543 945 6812934
SGTC_21 0849-0113 22.993 µM 0.840445022944551 0.189373689625509 no 677 0.200329457152214 973 1560156
SGTC_1091 telmisartan 47.6 µM 0.839176541514207 0.189698376110311 no 678 0.200685124583314 1017 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1011 4112-3381 17.4 µM 0.838307859631046 0.189920925426256 no 679 0.200928911415263 961 2877139
SGTC_318 1488-0629 67.2 µM 0.838199767333904 0.189948629028618 no 680 0.200959258856458 939 3662576
SGTC_2306 7482397 179.52 µM 0.836920325014683 0.190276733427291 no 681 0.201318677412931 981 891448
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.836322250130171 0.190430225055233 no 682 0.201486819578294 1023 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2708 st078559 56 µM 0.835969316901233 0.190520838500145 no 683 0.201586082337296 902 17250902
SGTC_249 wiskostatin 11.211 µM 0.835722937781564 0.190584110518092 no 684 0.201655394027252 1011 2775510 A n-wasp and actin depolymerizer.
SGTC_1984 st072354 53.1 µM 0.835463227476501 0.190650820048612 no 685 0.201728471515762 981 5762938
SGTC_3199 9111318 49.47 µM 0.834911564816536 0.190792568393179 no 686 0.201883751401937 956 8548020
SGTC_3157 9099274 49.47 µM 0.831059097671103 0.19178425185473 no 687 0.202970122372289 992 17217662
SGTC_2045 5106652 78.05 µM 0.830925834211048 0.191818612269293 no 688 0.203007764178455 1018 673349
SGTC_459 nigericin 15.3 µM 0.830467808060843 0.191936737656603 no 689 0.203137170746538 1071 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2596 sinensetin 100 µM 0.830170669504915 0.192013393784404 no 690 0.203221147918101 933 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_152 4469-0003 551.229 µM 0.828721820285415 0.192387437817996 no 691 0.203630917817636 1012 697280
SGTC_2235 salicylic acid 500 µM 0.826543176657961 0.19295072819443 no 692 0.204248018012519 1018 338 A COX inhibitor and kinase inhibitor.
SGTC_1417 3966-0327 90.4 µM 0.823765564810231 0.193670341321929 no 693 0.205036388614477 1052 651118
SGTC_3149 9097855 49.47 µM 0.821222248644077 0.194330687211091 no 694 0.205759842895023 975 25236625 YMR079W SEC14
SGTC_2859 9028643 45.46 µM 0.819255077484238 0.194842382026753 no 695 0.206320448430076 980 17151580
SGTC_1019 4262-0212 3.4 µM 0.819196819494279 0.194857548407669 no 696 0.206337064613726 1110 4677213
SGTC_1283 0922-0125 16.4 µM 0.816845641753175 0.195470232714833 no 697 0.20700832268617 1053 3360884
SGTC_192 3455-0609 60.9 µM 0.816304594317287 0.195611387596865 no 698 0.207162973685022 1009 3769639
SGTC_1733 st037357 54.9 µM 0.815907291179618 0.195715080157611 no 699 0.207276580849283 1024 1272339 YGL099W LSG1
SGTC_1407 3909-7909 12.3 µM 0.812722049051702 0.196547605289835 no 700 0.208188718325186 1045 4411780
SGTC_496 calpeptin 138 µM 0.812412213098023 0.196628701308628 no 701 0.208277570299038 976 73364 A calpain inhibitor.
SGTC_1648 st011736 69.8 µM 0.809876061739195 0.197293271661088 no 702 0.209005705660618 1011 2855514
SGTC_1430 4049-0248 69.1 µM 0.809586594513701 0.197369209630374 no 703 0.209088907639617 1097 22774488
SGTC_1374 2889-5571 141 µM 0.809033400106451 0.197514382165345 no 704 0.209247967341685 1025 2853281
SGTC_2772 vinpocetine 57.06 µM 0.806347528840591 0.198220141500805 no 705 0.210021246304806 997 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2654 protoveratrine a 100 µM 0.806176329416892 0.198265178672321 no 706 0.210070592537016 1043 5702278 A heart drug and vasodilator.
SGTC_305 1682-2595 20.8 µM 0.80604671101142 0.198299281296734 no 707 0.210107958057478 1035 226033
SGTC_2802 7925815 54.55 µM 0.805487037818608 0.198446572048933 no 708 0.210269341693565 1011 1262923
SGTC_683 panaxydol 45 µM 0.800341744846952 0.199803763538823 no 709 0.211756411521906 1058 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_45 0kpi-0036 14.9 µM 0.797597525854477 0.200529892897253 no 710 0.212552043633483 1002 2795021
SGTC_1365 1672-3266 55.4 µM 0.796769987840334 0.200749172785815 no 711 0.212792314171458 1062 6415873
SGTC_1548 st061468 90.8 µM 0.796732222169066 0.200759183314359 no 712 0.212803282981862 1068 390799
SGTC_1791 st048313 56.1 µM 0.7962960079193 0.20087483213397 no 713 0.21293000268905 1001 1204976
SGTC_803 4488-1585 147 µM 0.796286768749994 0.200877282048373 no 714 0.21293268713259 1018 747204
SGTC_2252 omeprazole 400 µM 0.795678481935018 0.201038618530842 no 715 0.213109468507145 969 4594 A proton pump inhibitor.
SGTC_2292 7671323 168.05 µM 0.793910131487639 0.201508080996754 no 716 0.213623875549994 1022 937504
SGTC_2940 9060638 45.86 µM 0.793098061571512 0.201723889593052 no 717 0.213860346063391 1015 4027022
SGTC_2563 tomatine 8.54 µM 0.792865942976949 0.201785600828254 no 718 0.213927965783798 1048 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2127 5253358 187.912 µM 0.79156297879437 0.202132217713686 no 719 0.214307770286117 983 20612
SGTC_3164 9100705 49.47 µM 0.789848746909934 0.202588783055163 no 720 0.214808053276263 1030 17174235
SGTC_1564 D-Arginine 115 µM 0.78933895095521 0.20272467998994 no 721 0.21495696338048 1044 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1224 0823-0416 294 µM 0.788296643957745 0.203002698530728 no 722 0.215261605129578 1065 3598164
SGTC_268 camptothecin 39.6153 µM 0.788127899753875 0.203047729723902 no 723 0.215310948635024 1092 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.787803028419346 0.203134441903061 no 724 0.215405964691136 1097 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.78753007766577 0.203207312923454 no 725 0.215485814186537 1073 6312947
SGTC_2463 5473429 200 µM 0.784244274703768 0.204085763977285 no 726 0.216448395266812 1021 5399405
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.782792222848206 0.204474685971237 no 727 0.216874567649125 1182 688664
SGTC_2963 9082507 9 µM 0.781603715949111 0.204793347324865 no 728 0.217223751195201 1015 16459611
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.778852160872895 0.205532224166588 no 729 0.2180334036104 1051 616764
SGTC_487 nimodipine 119 µM 0.775823506066584 0.206347337900928 no 730 0.218926601451999 996 4497 L-type voltage-gated calcium channels inhibitor
SGTC_474 dl-dihydrosphingosine 5 µM 0.775344610279247 0.206476400178782 no 731 0.219068027812073 1113 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.774748644004137 0.206637079690174 no 732 0.219244100499028 1060 5282362
SGTC_2095 5432005 200 µM 0.774698278925864 0.206650662099755 no 733 0.219258984119176 1052 783734
SGTC_488 nitrendipine 139 µM 0.77455532619679 0.206689216344627 no 734 0.21930123191297 1086 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_756 0508-1999 28.3 µM 0.774032778550776 0.206830183292627 no 735 0.219455703780209 1059 6753853
SGTC_638 3970-0837 4.09 µM 0.77377322083126 0.206900224965921 no 736 0.219532455641918 1073 4118451 YLR208W SEC13
SGTC_1171 0368-0077 21.4 µM 0.772156708617503 0.207336756798135 no 737 0.220010809217748 1030 3239779
SGTC_2926 9010726 65.15 µM 0.770820778426708 0.207697929365097 no 738 0.220406584703909 1085 2994293
SGTC_3355 9151058 44.0485 µM 0.770803536517804 0.20770259319286 no 739 0.22041169536496 1113 17015728
SGTC_3237 9133362 49.47 µM 0.768602446534503 0.208298482092177 no 740 0.221064676344178 1054 43845137
SGTC_3039 9090270 49.47 µM 0.767692074896817 0.208545236498612 no 741 0.221335072804828 1092 17173750
SGTC_1879 gemcitabine 100 µM 0.76627232497874 0.208930400649841 no 742 0.221757140875424 1089 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2102 5377816 72.7585 µM 0.765535476496916 0.209130465444971 no 743 0.221976374808695 1119 1379702
SGTC_3020 9089140 49.47 µM 0.765494248565489 0.209141662743282 no 744 0.221988644976544 1117 17217859
SGTC_2365 9042475 200 µM 0.764074833543882 0.20952738394291 no 745 0.222411324322388 1117 6464479
SGTC_2784 7567673 72.73 µM 0.764047236277278 0.209534887551044 no 746 0.222419546898586 1125 3471247
SGTC_1020 4335-0961 93.3 µM 0.763263110690598 0.209748154823648 no 747 0.222653248720797 1000 669075
SGTC_135 0933-0004 26.348 µM 0.762470725013644 0.209963798277422 no 748 0.222889554520526 1028 21230617 YGL099W LSG1
SGTC_2084 5306078 60.6385 µM 0.759896457063307 0.210665269881165 no 749 0.223658239781783 1057 679340
SGTC_266 formosanin C 406 nM 0.759592181395423 0.210748273826949 no 750 0.223749197052403 1102 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2311 7694451 200 µM 0.759291880074294 0.210830212409289 no 751 0.223838986884496 1038 2163142
SGTC_1873 rapamycin 2 nM 0.759200222191472 0.210855225400837 no 752 0.223866396589947 1091 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_852 0418-0143 439 µM 0.758380471707043 0.211079008701187 no 753 0.224111622548735 1156 5369229
SGTC_1800 st050079 29.0735 µM 0.756121049028122 0.211696527580541 no 754 0.224788311439857 1125 3645560
SGTC_1871 st057448 67.3 µM 0.755572258013131 0.211846676139429 no 755 0.224952847060195 1147 691747
SGTC_2006 4011487 200 µM 0.755412747417956 0.211890329729606 no 756 0.225000683483968 1119 45595294
SGTC_453 enantio-paf c16 10 µM 0.755277628983883 0.211927311983704 no 757 0.225041209331171 1117 13871343 A lipid and platelet activating factor
SGTC_1228 0124-0032 52.5 µM 0.754926758168792 0.21202336383584 no 758 0.225146464745181 1137 X1228
SGTC_2783 7738165 71.43 µM 0.754606681256251 0.212111007973968 no 759 0.225242506820783 1046 17201110
SGTC_1249 0481-0015 10.2 µM 0.753890520218652 0.212307185411629 no 760 0.225457481668999 1089 4227577
SGTC_2715 st079500 56.4 µM 0.75361638855344 0.212382306140294 no 761 0.225539800332122 1054 28246688
SGTC_3269 9137823 49.47 µM 0.751684467142246 0.212912153833294 no 762 0.226120416792961 1030 17682936
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.748620904162354 0.213753944586908 no 763 0.227042864474018 1099 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_313 3474-0040 5.03 µM 0.747143727935533 0.214160527488929 no 764 0.22748840358615 1108 1043375 YIL048W NEO1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.746609012782439 0.214307815122799 no 765 0.227649803219833 1216 688801
SGTC_2382 9035899 200 µM 0.746529529740202 0.214329713807008 no 766 0.22767380006384 1151 6462679
SGTC_2702 st077768 96.8 µM 0.746465916159499 0.214347241171354 no 767 0.227693006760876 1046 6484119
SGTC_2408 sulbentine 18.36 µM 0.745571216241089 0.214593844938299 no 768 0.227963237984636 1069 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_55 0767-0285 6.563 µM 0.744635701552975 0.214851874656245 no 769 0.228245989567972 1111 3116166
SGTC_1301 naphtanilide LB 4.81 µM 0.743667729472222 0.215119046258642 no 770 0.228538758539872 1172 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2960 9079389 5.97 µM 0.743539164513359 0.215154546193363 no 771 0.228577659647205 1110 16457355
SGTC_3333 9141820 12.094 µM 0.74350244041206 0.215164687241804 no 772 0.228588772286387 1056 1939433
SGTC_1265 0819-1001 68.8 µM 0.741855155657146 0.215619856202446 no 773 0.229087549298263 1130 3106768
SGTC_2995 9067767 71.4286 µM 0.741805560180245 0.215633568813108 no 774 0.229102575642827 1091 11673567
SGTC_1402 3909-7673 35.9 µM 0.740149049273218 0.216091866500007 no 775 0.229604779706421 1131 5328014
SGTC_1055 3448-0672 86 µM 0.738099592570257 0.21665965834434 no 776 0.230226965667322 1089 748378
SGTC_198 3454-2873 16.191 µM 0.734883965611588 0.217552268784066 no 777 0.231205082210215 1145 710957
SGTC_1849 st056239 19.2 µM 0.733114897226176 0.218044239644154 no 778 0.231744177408262 1106 5393181
SGTC_2105 5350118 200 µM 0.731891831149959 0.218384744093654 no 779 0.232117296261711 1161 2133313
SGTC_584 0986-0246 15.4 µM 0.731289466769061 0.218552556248492 no 780 0.232301181446481 1243 53315 YDR232W HEM1
SGTC_1280 0880-0253 10.1 µM 0.729835635544032 0.218957883494002 no 781 0.232745329597477 1116 6836607
SGTC_290 2043-6722 48.1 µM 0.72923565761313 0.219125282929216 no 782 0.232928761446341 1157 773758 YLR208W SEC13
SGTC_1167 k781-0610 148 µM 0.726604031840268 0.219860399705836 no 783 0.233734278826896 1151 4525169
SGTC_1704 st028805 70.8 µM 0.726580243661699 0.219867051130121 no 784 0.233741567213155 1145 2876101
SGTC_148 3253-0744 288.01 µM 0.72624257584892 0.219961479046937 no 785 0.233845037791617 1149 6893655
SGTC_3064 1327-0027 10 µM 0.724538028648643 0.220438506272716 no 786 0.23436774456647 1038 16000455 YPR107C YTH1
SGTC_3291 9121177 71.43 µM 0.723793163488129 0.220647147040624 no 787 0.234596363543018 1080 17015612
SGTC_1399 3562-5772 25 µM 0.723752191138899 0.22065862689907 no 788 0.234608942627246 1091 23847490
SGTC_2539 epi(13)torulosol 80 µM 0.721246168516228 0.221361428262352 no 789 0.235379035384923 1145 6708597
SGTC_58 0957-0393 9 µM 0.721028627166997 0.221422496954777 no 790 0.235445950898778 1151 6997992
SGTC_2612 dictamnine 15.46 µM 0.720747858491626 0.221501329200306 no 791 0.235532330594664 1104 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2771 fluoxetine 41.05 µM 0.720346179576871 0.221614137659454 no 792 0.235655939242663 1146 3386 A selective serotonin reuptake inhibitor.
SGTC_1349 flufenamic acid 69 µM 0.720185726923759 0.221659208738693 no 793 0.235705325334729 1133 3371 A non-steroidal anti-inflammatory.
SGTC_317 4495-0002 170 µM 0.720094547163091 0.221684823426914 no 794 0.235733392306637 1125 15991618
SGTC_1010 4112-3296 15.2 µM 0.718189832584025 0.222220292214057 no 795 0.236320123098823 1193 704384
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.716448602614551 0.222710445988918 no 796 0.236857196620491 1127 688662
SGTC_2976 9009005 19.48 µM 0.715701465717642 0.222920952747349 no 797 0.23708785279018 1180 2993148
SGTC_2077 5212015 200 µM 0.715219308299759 0.223056861358288 no 798 0.237236769973269 1104 780900
SGTC_2286 7945697 125 µM 0.714892978281826 0.22314887273165 no 799 0.237337588084546 1147 1245733
SGTC_1574 spiramycin 23.7 µM 0.71263406088379 0.223786384861739 no 800 0.238036114595176 1193 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1784 st039334 36.3 µM 0.711617273970411 0.224073680214182 no 801 0.238350903670329 1192 3496984
SGTC_2757 clomiphene 4.22 µM 0.710830346804893 0.22429617193779 no 802 0.238594686429381 1223 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3240 9133527 49.47 µM 0.7105923724357 0.224363480273208 no 803 0.238668435553786 1149 17617455
SGTC_2441 5730946 39.09 µM 0.709994111762197 0.224532742110994 no 804 0.238853893802493 1178 1774275
SGTC_790 1575-0012 79.1 µM 0.709844991763755 0.224574942898791 no 805 0.238900132632519 1207 378741 YLR208W SEC13
SGTC_184 1494-0393 24.714 µM 0.709019366187543 0.224808675396094 no 806 0.239156229514364 1182 3090647
SGTC_2738 aclarubicin 5.55 µM 0.708306381777531 0.22501063040476 no 807 0.239377507436264 1089 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_840 0245-0196 390 µM 0.708191303019416 0.225043236447923 no 808 0.239413233124993 1231 3827528
SGTC_2022 5136654 200 µM 0.708160960097451 0.225051834159336 no 809 0.239422653435276 1161 1713771
SGTC_2533 agelasine 13.65 µM 0.70800096038223 0.225097173391455 no 810 0.239472330541047 1214 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3134 9127454 49.47 µM 0.706563370434215 0.225504776343811 no 811 0.239918929378481 1265 24262820
SGTC_2009 4012297 12.05 µM 0.705703353212834 0.225748818446788 no 812 0.240186317623366 1160 45595307
SGTC_2148 5546263 113.568 µM 0.705401276186689 0.225834572533728 no 813 0.240280275021558 1150 792097
SGTC_2055 5235184 200 µM 0.702461314503473 0.226670134883441 no 814 0.241195759562594 1172 2836034
SGTC_289 k017-0060 526 µM 0.702264036044093 0.226726265512182 no 815 0.241257258569834 1178 5512909
SGTC_773 4358-1457 44.6 µM 0.702250068445654 0.226730239938664 no 816 0.24126161311094 1221 1186886
SGTC_559 1550-0661 158 µM 0.699829579079511 0.227419574333881 no 817 0.242016869999801 1192 5830875
SGTC_1106 tegaserod maleate 11.7 µM 0.699483034791461 0.227518363665422 no 818 0.242125105846968 1203 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_806 3966-4455 5.86 µM 0.698839713742012 0.227701819165585 no 819 0.242326103261163 1117 714982
SGTC_1678 st019265 80.2 µM 0.697662215480397 0.228037821268751 no 820 0.242694231584444 1206 5367020
SGTC_85 0868-0259 160.055 µM 0.696759768268172 0.228295525508204 no 821 0.242976573855933 1135 83173
SGTC_3217 9129673 49.47 µM 0.69501023510392 0.228795590908697 no 822 0.243524443674451 1198 17248312
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.693063178754961 0.229352836162484 no 823 0.244134951954396 1198 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_678 1218-2179 85.9 µM 0.69291866901375 0.229394224988331 no 824 0.244180296512631 1195 6820081 YOR116C RPO31
SGTC_1316 1272-0050 65.9 µM 0.692703094353146 0.229455975194892 no 825 0.244247948403796 1195 7340392
SGTC_2721 ifenprodil 61.44 µM 0.690430618896759 0.230107480004554 no 826 0.244961713578778 1208 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1415 3966-0071 78.1 µM 0.689613696752092 0.230341939244319 no 827 0.245218575831412 1190 2893185
SGTC_2914 7968218 45.32 µM 0.688765129497693 0.230585622107084 no 828 0.245485541420879 1137 2977111
SGTC_1309 pyrazolanthrone 13.4 µM 0.687768246851649 0.230872080603912 no 829 0.245799367512436 1234 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_724 3910-0327 137 µM 0.68770663511793 0.230889791517393 no 830 0.24581877040988 1213 2885483
SGTC_2690 usnic acid 100 µM 0.684358975900644 0.231853249574182 no 831 0.246874257202156 1265 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_76 0433-0009 400.328 µM 0.684137146019462 0.231917171342107 no 832 0.246944283758635 1186 2841569
SGTC_1657 st012939 43.4 µM 0.682149431602759 0.232490382356064 no 833 0.247572233243928 1237 24207257
SGTC_171 k064-0041 9.68 µM 0.679828128588791 0.233160788745985 no 834 0.248306646902962 1181 53325
SGTC_3347 9188721 44.724 µM 0.67951965934131 0.233249957245233 no 835 0.248404327732089 1216 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_359 0081-0058 15.9 µM 0.679280859956063 0.233318999431898 no 836 0.248479960748759 1305 3494159
SGTC_648 0375-0473 33.3 µM 0.677448553593345 0.23384913691473 no 837 0.249060700551889 1222 1713139
SGTC_588 3970-1144 52.9 µM 0.677224923330284 0.23391388507911 no 838 0.249131628391294 1159 1888707
SGTC_68 0986-0284 82.829 µM 0.675118534406197 0.234524239663255 no 839 0.249800229487098 1198 423278 YIL048W NEO1
SGTC_2423 st077119 87.2 µM 0.675021336168136 0.23455242541151 no 840 0.24983110472012 1194 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1364 1653-0028 37.6 µM 0.674894167307991 0.234589304932661 no 841 0.249871503245906 1204 5718652
SGTC_1129 3453-1384 223 µM 0.674801441956985 0.234616197708429 no 842 0.24990096207297 1293 1084452
SGTC_1559 coumarin 343 70.1 µM 0.674579223594211 0.234680653781423 no 843 0.249971568308153 1251 108770 A hepatotoxic, DNA x-linker.
SGTC_1779 st039427 55 µM 0.674393844100696 0.23473443195956 no 844 0.250030477696 1275 1124498
SGTC_866 0495-0101 262 µM 0.674206732490344 0.234788719529402 no 845 0.250089944979977 1197 635694
SGTC_38 0929-0051 58.268 µM 0.67401433535089 0.234844547851216 no 846 0.250151099919157 1231 1379719
SGTC_1261 0712-0010 12.7 µM 0.673041594649492 0.235126922561231 no 847 0.25046041456748 1246 2840123
SGTC_232 clozapine 119 µM 0.671871032697926 0.235466970818147 no 848 0.250832901479464 1190 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3040 9091894 49.47 µM 0.67038764524492 0.23589828446727 no 849 0.251305354206152 1173 25236966
SGTC_3277 9138724 49.47 µM 0.669856977132781 0.236052688622531 no 850 0.251474483978838 1176 15943418
SGTC_1163 k060-0048 49.9 µM 0.669486574339907 0.236160494679596 no 851 0.251592571064097 1255 6809982
SGTC_1999 st074831 12.5 µM 0.66930715910752 0.236212723388131 no 852 0.251649780465031 1224 17112523
SGTC_2705 st078069 42.8 µM 0.667927495587411 0.236614563098079 no 853 0.252089937596501 1214 1530061
SGTC_635 k038-0028 24.7 µM 0.667773221519671 0.236659520208729 no 854 0.252139181230329 1265 4035102
SGTC_883 0850-0245 24.6 µM 0.667207138242256 0.236824523167937 no 855 0.252319916089329 1284 6823229 YPR165W RHO1
SGTC_845 0330-0138 4.51 µM 0.66527796915417 0.23738731564412 no 856 0.252936359468046 1218 9039800
SGTC_1134 3477-0009 42.5 µM 0.661265014095935 0.238560355549741 no 857 0.254221186941421 1310 3973534
SGTC_2880 9042983 58.44 µM 0.661097522877197 0.238609384331503 no 858 0.25427488689063 1263 6464714
SGTC_2941 9056145 11.23 µM 0.658825792832673 0.239274919700472 no 859 0.255003821190893 1152 2119517
SGTC_2505 galangin 7.89 µM 0.658669786316831 0.23932066119516 no 860 0.255053919382696 1196 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_368 fentichlor 4.58 µM 0.65799165835106 0.239519545482028 no 861 0.255271745647837 1229 7329 A pesticide.
SGTC_114 0364-0001 490.298 µM 0.656730568161468 0.23988964326195 no 862 0.255677087774722 1242 4003655
SGTC_2974 9094440 9.66 µM 0.656009923517083 0.240101274038263 no 863 0.255908869631198 1326 25236134
SGTC_528 3492-0019 172 µM 0.655406430288993 0.240278579384526 no 864 0.256103056254206 1297 2869262
SGTC_97 0535-0701 19.132 µM 0.655019932412412 0.240392169308108 no 865 0.256227460421735 1216 2832013 YGL099W LSG1
SGTC_611 3453-1652 23.7 µM 0.654916846260485 0.240422470787901 no 866 0.256260646641954 1264 1560575
SGTC_1581 himbacine 57.9 µM 0.652833635589315 0.24103526211381 no 867 0.256931768362633 1259 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_492 tmb-8 126 µM 0.651154259343847 0.241529880305324 no 868 0.257473456837439 1165 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3200 9114385 49.47 µM 0.6507373428749 0.241652757953139 no 869 0.257608026517477 1248 17018030 YLR208W SEC13
SGTC_166 k072-0058 166.424 µM 0.650516949437775 0.241717728144584 no 870 0.257679178481185 1271 5846229
SGTC_855 0428-0020 25 µM 0.650057699093922 0.241853141865215 no 871 0.257827475942807 1256 6812414
SGTC_3221 9128209 49.47 µM 0.64518814093448 0.243291499781031 no 872 0.259402635189006 1301 16460723
SGTC_465 cgp-37157 41 µM 0.644461200940594 0.243506617422761 no 873 0.259638204682854 1213 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3338 9144300 39.5675 µM 0.644351794297696 0.243539002164148 no 874 0.259673668154846 1269 4901274
SGTC_2293 7624732 200 µM 0.640439764265698 0.244698503745188 no 875 0.260943369044395 1252 894453
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.639588311704276 0.244951262331261 no 876 0.261220141650185 1262 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2363 9053361 176 µM 0.638608730478828 0.24524223033943 no 877 0.261538750171321 1346 6469797 YMR079W SEC14
SGTC_422 cantharidin 155 µM 0.636725612473343 0.245802100208188 no 878 0.262151793651702 1246 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_815 1582-0027 36.9 µM 0.636451991431029 0.245883507540934 no 879 0.262240931399864 1321 3128206
SGTC_1503 4585-0012 61.3 µM 0.636064784747246 0.245998733430376 no 880 0.262367098562083 1320 2922052
SGTC_568 1193-0097 7.48 µM 0.635750662915186 0.246092231835571 no 881 0.262469474638706 1207 3646150
SGTC_1452 4194-0072 190 µM 0.635140063249434 0.246274031431807 no 882 0.26266853489726 1366 1343545
SGTC_2986 9022445 71.43 µM 0.63303073446176 0.246902615392704 no 883 0.263356786364031 1270 6459286
SGTC_406 estrone 100 µM 0.631088744484679 0.247482090391297 no 884 0.263991250081727 1352 5870 A steroid.
SGTC_826 1683-5028 118 µM 0.630180685754544 0.247753297332753 no 885 0.26428818721129 1315 722377
SGTC_363 0455-0021 3.06 µM 0.630136624787443 0.247766460913869 no 886 0.264302599565818 1327 4597466
SGTC_1923 st058458 19.1 µM 0.629906296843649 0.247835279384523 no 887 0.264377946412924 1378 3534982
SGTC_1924 st058459 75.1 µM 0.629435167355366 0.247976077454107 no 888 0.264532100369963 1258 688683
SGTC_1666 st014829 29 µM 0.629311892094817 0.248012925577356 no 889 0.264572443684417 1303 3858230
SGTC_292 k038-0015 474 µM 0.628787432153936 0.248169724185692 no 890 0.264744114498303 1286 46368540
SGTC_346 4513-0042 7.16 µM 0.62681903329949 0.248758690751205 no 891 0.265388932846541 1310 2827372
SGTC_2393 9031399 185.94 µM 0.626460180003787 0.248866143753742 no 892 0.265506573718191 1345 1526623 YDL150W RPC53
SGTC_1502 4534-4282 27.7 µM 0.625470368889361 0.24916265521315 no 893 0.265831195030795 1299 3278949
SGTC_334 1502-1024 68.5 µM 0.624732251040187 0.24938389075516 no 894 0.266073401157822 1322 3296216
SGTC_1497 4476-2978 41.3 µM 0.623757166611144 0.249676312125905 no 895 0.266393536796068 1316 1528379
SGTC_1659 st012954 42.1 µM 0.623375916480093 0.249790696020641 no 896 0.266518760218199 1306 24207262
SGTC_1926 methyl fluorone black 53.6 µM 0.622235447583473 0.250133029211001 no 897 0.266893530308148 1167 72721 Reacts with homocysteine.
SGTC_2606 farnesol 9.78 µM 0.62216618140426 0.250153828770753 no 898 0.26691630047693 1342 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1981 st071826 47 µM 0.619813970523613 0.250860705430505 no 899 0.267690134920161 1275 11838600
SGTC_1422 4031-0024 15.5 µM 0.619761543568986 0.250876472598856 no 900 0.267707395303501 1255 782427
SGTC_1181 1222-0449 220 µM 0.618085759504688 0.25138073328016 no 901 0.268259404432519 1370 658318
SGTC_664 1222-0054 14.9 µM 0.618010722125478 0.251403325325569 no 902 0.268284135395771 1299 6813991
SGTC_3058 9093861 49.47 µM 0.61730487345065 0.251615892797264 no 903 0.26851682647864 1336 17217477
SGTC_1769 st044406 64.4 µM 0.617177302921039 0.251654320996436 no 904 0.268558892384308 1320 670903
SGTC_720 r052-1644 49.9 µM 0.616597960499232 0.251828875895015 no 905 0.268749970053028 1290 1422863 YOR257W CDC31
SGTC_2736 butenafine 14.65 µM 0.615507470968919 0.252157611868359 no 906 0.269109818494376 1313 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2948 9070189 9.45 µM 0.614925801592564 0.252333052836246 no 907 0.26930186122598 1257 6473636 YDL196W YDL196W
SGTC_384 k007-0144 5.16 µM 0.612775281161339 0.252982243194498 no 908 0.270012468738776 1339 6824886
SGTC_1207 2099-0101 141 µM 0.612497707402189 0.253066100025514 no 909 0.270104257184335 1332 5837381
SGTC_2380 9035439 200 µM 0.611580864562597 0.253343188074768 no 910 0.270407550832867 1381 6462575
SGTC_2344 7990960 76.95 µM 0.611249261657672 0.253443444292263 no 911 0.270517287708191 1334 140813
SGTC_1805 st050013 60.3 µM 0.610818279505198 0.253573777802528 no 912 0.270659945258794 1308 4037144
SGTC_1797 st048695 56.8 µM 0.610426396490362 0.253692317880527 no 913 0.270789693375436 1295 592262 YIL048W NEO1
SGTC_2000 st075254 36.4 µM 0.608657799020861 0.254227659969911 no 914 0.271375642355921 1307 17234175
SGTC_1718 roemerine 11.9335 µM 0.607544206793655 0.254565040205322 no 915 0.271744907276739 1272 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1948 st076329 66.6 µM 0.607255310221329 0.254652604254449 no 916 0.271840745632115 1252 24208413
SGTC_2842 9000675 19.48 µM 0.605822808367077 0.255087025996794 no 917 0.272316211139903 1272 2989072
SGTC_2743 auranofin 4.32 µM 0.605057051177775 0.255319409073315 no 918 0.272570545004454 1294 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3103 9120822 49.47 µM 0.604863894875445 0.255378043371187 no 919 0.272634717364982 1393 17141819
SGTC_649 1123-0311 367 µM 0.604157046537277 0.255592673397007 no 920 0.272869617655224 1329 693629 YIL048W NEO1
SGTC_2845 9003024 42.97 µM 0.603463805007875 0.255803263278299 no 921 0.273100093578968 1424 2990173
SGTC_1462 k081-0014 26.5 µM 0.602801309274257 0.256004597939026 no 922 0.273320437836975 1152 3270634
SGTC_2226 7298446 200 µM 0.601770630952768 0.256317988788507 no 923 0.273663413562195 1333 3283010
SGTC_620 0109-0052 432 µM 0.600368881220584 0.256744529308295 no 924 0.274130211056511 1345 493037
SGTC_2598 perillyl alcohol 100 µM 0.600172892480438 0.256804196445221 no 925 0.274195508710326 1390 10819 An apoptosis inducer.
SGTC_1911 st060208 74.3 µM 0.599315077854678 0.257065435853938 no 926 0.274481397545067 1398 688783
SGTC_56 0957-0365 83.25 µM 0.599136395625176 0.257119869241814 no 927 0.274540966508948 1289 6752360
SGTC_3152 9099253 49.47 µM 0.598630178653818 0.257274114679903 no 928 0.274709763412595 1328 25236131
SGTC_1465 k213-0056 144 µM 0.597019503639172 0.257765210729683 no 929 0.275247179569593 1311 24048857 YMR208W ERG12
SGTC_1990 st072050 59.8 µM 0.596117157129924 0.258040549373581 no 930 0.275548481592916 1331 17233948
SGTC_931 2812-0076 566 µM 0.59470815037259 0.258470793287142 no 931 0.276019286409985 1358 3450959
SGTC_1778 st046819 58.9 µM 0.592668712519608 0.25909419851927 no 932 0.276701442064588 1369 671715
SGTC_323 4013-0906 34.3 µM 0.591862580391805 0.259340827190663 no 933 0.27697130651855 1394 2910086
SGTC_3059 1327-0034 3 µM 0.590300095863047 0.259819200049543 no 934 0.277494737565643 1304 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_252 miconazole 1.30953 nM 0.590291656372319 0.259821785133681 no 935 0.277497566100397 1315 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1038 k292-0204 154 µM 0.589280584907014 0.260131580485667 no 936 0.277836533355205 1285 4454212
SGTC_2220 6782180 200 µM 0.589004482629321 0.260216212143826 no 937 0.277929133283806 1315 833803
SGTC_2583 asiatic acid 100 µM 0.587346210504006 0.260724808825676 no 938 0.278485605767159 1354 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_216 k038-0035 28.382 µM 0.58713512239326 0.260789586819842 no 939 0.278556480309035 1304 4444231 YPR107C YTH1
SGTC_2128 5255449 168.493 µM 0.585791043957448 0.261202247124789 no 940 0.279007971482274 1328 736008
SGTC_2338 7999974 200 µM 0.584896638112845 0.261477034314527 no 941 0.27930860963038 1404 315925
SGTC_2321 7390090 138.78 µM 0.584734247942024 0.261526941159795 no 942 0.279363210991767 1300 649046
SGTC_3234 9132280 49.47 µM 0.583468016573812 0.261916255601706 no 943 0.279789140857266 1351 17612295
SGTC_907 3448-6986 75.5 µM 0.583419794937952 0.261931087657751 no 944 0.279805367684396 1446 590582
SGTC_575 k072-0246 11.9 µM 0.581844015300207 0.262416004311835 no 945 0.280335876654614 1378 6796779
SGTC_2691 st077356 60.2 µM 0.581454385448214 0.262535976437866 no 946 0.280467126241963 1447 2839272
SGTC_1393 3470-5649 58.2 µM 0.580227354771123 0.262913978560946 no 947 0.280880654484427 1326 4108395
SGTC_2536 dehydroabietamide 32.04 µM 0.579515797701608 0.263133310000333 no 948 0.281120595123316 1457 3983547
SGTC_1456 k015-0012 13 µM 0.578085784541209 0.263574382001103 no 949 0.281603101993075 1436 2989616
SGTC_1353 1498-1206 8.11 µM 0.577106223195692 0.263876734611851 no 950 0.281933850316229 1395 6756808
SGTC_319 1348-1596 45.5 µM 0.575684040422941 0.264316021792192 no 951 0.282414382338969 1466 5380505
SGTC_2800 7887935 81.82 µM 0.574763192179017 0.264600654032772 no 952 0.282725731687309 1407 2961002
SGTC_994 3910-0338 138 µM 0.574757061933729 0.264602549400919 no 953 0.282727804946025 1469 3479481
SGTC_283 0987-0079 11.7 µM 0.573264824936187 0.265064129204827 no 954 0.283232699062366 1395 411556
SGTC_573 3702-0553 84.7 µM 0.570616642919057 0.265884272554103 no 955 0.28412976720003 1358 1222756
SGTC_1310 1188-0297 994 nM 0.570146891780134 0.266029888894533 no 956 0.284289036557837 1346 1588352
SGTC_3024 9090631 49.47 µM 0.569904303520201 0.266105103705239 no 957 0.284371302934385 1348 25236383
SGTC_425 3825-7017 13.1 µM 0.567891362956605 0.266729633717054 no 958 0.285054368518939 1457 3397440
SGTC_349 k015-0014 24 µM 0.567489419987675 0.266854428235103 no 959 0.285190856352901 1370 2196908
SGTC_971 1315-0384 26.7 µM 0.566849284551346 0.267053237199747 no 960 0.28540829151295 1374 6769120
SGTC_800 3448-7362 155 µM 0.563768839385021 0.268010985901879 no 961 0.286455730527437 1459 15991913
SGTC_2089 5281248 129.67 µM 0.563757422223067 0.268014538853532 no 962 0.286459616078008 1385 2737878
SGTC_778 3456-2434 196 µM 0.561637822882575 0.268674555917673 no 963 0.287181402579694 1508 5539063
SGTC_281 1672-3440 14.9 µM 0.561562173491339 0.268698127289275 no 964 0.287207179346653 1404 6833000
SGTC_1747 st037496 66.6 µM 0.558176410400432 0.269754149950556 no 965 0.288361963724684 1397 723305
SGTC_3308 9128332 17.569 µM 0.557368394317598 0.270006477772015 no 966 0.28863787749333 1490 17332805 YDL196W YDL196W
SGTC_1214 0358-0031 63.7 µM 0.554817493796541 0.270803848962345 no 967 0.289509750099695 1601 4301366
SGTC_1838 st055369 84.5 µM 0.554479293328638 0.27090965326716 no 968 0.289625436474396 1359 676036
SGTC_1700 st030840 7.9285 µM 0.552240135355087 0.271610682488185 no 969 0.290391919846379 1481 5499307
SGTC_354 2783-3500 4.88 µM 0.550602581716828 0.272123934335498 no 970 0.29095306934438 1362 6740761
SGTC_2608 thymoquinone 42.66 µM 0.548108401802822 0.272906600416329 no 971 0.291808735949287 1335 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1150 3909-7983 10.9 µM 0.546993217776246 0.273256902564345 no 972 0.292191695818051 1378 23965914
SGTC_2058 5236698 133 µM 0.545580594084076 0.273700956142474 no 973 0.292677133414824 1421 766665
SGTC_2123 5259487 200 µM 0.545083169124607 0.273857404965639 no 974 0.292848158926932 1452 2173474
SGTC_1251 0490-5699 265 µM 0.544836090537645 0.273935131921949 no 975 0.292933127156582 1472 3883818
SGTC_2683 piperine 63.03 µM 0.544654989940308 0.273992110186964 no 976 0.292995413380554 1390 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1545 lovastatin 49.4 µM 0.544134651332607 0.27415585283893 no 977 0.293174408469033 1457 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2919 7978188 46.38 µM 0.541421553143132 0.275010405884389 no 978 0.29410852735827 1453 2980291
SGTC_502 l-744,832 89.3 µM 0.540054960949341 0.275441342103963 no 979 0.294579564972226 1444 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_779 1360-0071 233 µM 0.539489086268727 0.275619880179654 no 980 0.294774712764375 1581 7566
SGTC_2506 ethyl hematommate 54.16 µM 0.538725973719618 0.275860738482009 no 981 0.295037974443243 1375 3940691 An allergen.
SGTC_2902 5787006 60.46 µM 0.538596283729126 0.275901682317195 no 982 0.295082726189861 1414 591003
SGTC_2482 5981709 142.65 µM 0.537692010459989 0.276187249251582 no 983 0.295394847986241 1459 877755
SGTC_2997 9067075 71.4286 µM 0.536851888632196 0.276452687270123 no 984 0.295684963099473 1472 27209819
SGTC_2291 7917025 104.35 µM 0.534239468382359 0.277278884642161 no 985 0.296587932843265 1376 2964612
SGTC_2981 9013952 38.96 µM 0.532983427841895 0.277676546259678 no 986 0.297022526057962 1324 2996344
SGTC_1615 st002656 86.5 µM 0.532892624062289 0.277705305471183 no 987 0.297053955682575 1411 1584458
SGTC_315 k915-0449 187 µM 0.532108387812528 0.277953747902777 no 988 0.297325464161269 1489 20970215 YNL149C PGA2
SGTC_3071 9117417 49.47 µM 0.530286132069764 0.278531448628063 no 989 0.297956780164514 1445 45595590 YGL055W OLE1
SGTC_2096 5468907 200 µM 0.528528076548694 0.279089350030367 no 990 0.298566432646253 1508 759785
SGTC_2938 9059746 27.26 µM 0.52790856983246 0.279286073703975 no 991 0.298781398178292 1465 6471769
SGTC_2910 7948405 25.97 µM 0.527220220454163 0.27950473728779 no 992 0.299020334214066 1507 2971328
SGTC_1044 1222-0021 1.78 µM 0.526008368127965 0.279889900624133 no 993 0.299441196400196 1465 4306703
SGTC_151 3013-0144 2.285 µM 0.525278653010626 0.280121950265129 no 994 0.29969474743117 1521 906558 YHR107C CDC12
SGTC_170 4197-0004 226 µM 0.523971421958478 0.280537883121011 no 995 0.300149208466339 1477 218692
SGTC_798 1287-0182 476 µM 0.523671188982209 0.280633452996553 no 996 0.300253628948435 1540 1649755
SGTC_3282 9108498 15.4605 µM 0.521733920721896 0.281250500822388 no 997 0.300927801789788 1421 16459645
SGTC_1335 1486-0900 202 µM 0.520505622371435 0.28164207056728 no 998 0.301355605106024 1425 X1335
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.519735077081871 0.281887847130352 no 999 0.301624117558854 1590 1273210
SGTC_1782 st039423 80.636 µM 0.519318910298596 0.282020632508593 no 1000 0.301769184226582 1408 2068169
SGTC_248 streptozotocin 5.23457 mM 0.518396569983299 0.282315028829977 no 1001 0.302090803679891 1532 5300 DNA alkylating agent.
SGTC_1514 1189-1591 158 µM 0.517489240673938 0.282604778070873 no 1002 0.302407338887129 1541 767698 YMR146C TIF34
SGTC_1862 st057513 3.81 µM 0.517241363041426 0.28268396090421 no 1003 0.302493840515965 1443 5393163
SGTC_297 0986-0032 24 µM 0.516106871505817 0.283046502552557 no 1004 0.30288988446957 1423 2847425
SGTC_1673 st016611 27.3 µM 0.515439419425257 0.283259899837113 no 1005 0.303122996249952 1539 5226799
SGTC_2707 st078556 66.6 µM 0.515367965050267 0.283282749748911 no 1006 0.30314795688829 1497 17250899
SGTC_2576 guaiol 23.12 µM 0.515152728094394 0.283351584262302 no 1007 0.303223149606547 1532 227829
SGTC_2114 5491910 81.25 µM 0.512702256744613 0.284135829631509 no 1008 0.304079805421394 1537 2849228
SGTC_2452 5863136 48.41 µM 0.512585337249129 0.28417327431205 no 1009 0.304120706042964 1417 2184096
SGTC_2886 9058944 51.95 µM 0.509266621137554 0.285237110364849 no 1010 0.305282675582577 1402 4949929
SGTC_3238 9133470 49.47 µM 0.507362422429746 0.285848369214223 no 1011 0.305950273519486 1551 3534688
SGTC_1208 2323-2347 50.3 µM 0.507326611757187 0.285859870612778 no 1012 0.305962834663017 1509 5412760
SGTC_1288 0973-0013 65.5 µM 0.50677326239037 0.286037619103221 no 1013 0.306156959454322 1519 4315430
SGTC_1665 st014639 11.4 µM 0.506670793783409 0.286070540129252 no 1014 0.306192913238386 1544 981133 YIL048W NEO1
SGTC_1363 1636-0063 10.4 µM 0.505338456333935 0.286498756162997 no 1015 0.306660568419069 1472 6072185
SGTC_3136 9095672 49.47 µM 0.50505445548753 0.286590073935055 no 1016 0.306760294471715 1426 17217380
SGTC_3000 9075062 71.4286 µM 0.504838348486743 0.286659570334765 no 1017 0.306836189387006 1454 17057871
SGTC_402 epigallocatechin gallate 10 µM 0.50394477892927 0.286947012175 no 1018 0.307150091186681 1451 65064 An antioxidant.
SGTC_924 2046-0044 21.3 µM 0.500892442459813 0.287929910698735 no 1019 0.308223410811942 1436 3623589
SGTC_2398 5228213 48.84 µM 0.499729041050266 0.288304961530126 no 1020 0.308632940438338 1591 80771 YMR134W ERG29
SGTC_2094 5332512 191.667 µM 0.499192419878826 0.288478032060182 no 1021 0.308821917065038 1576 755774
SGTC_2643 anethole 100 µM 0.498676456352234 0.288644486265568 no 1022 0.309003666634902 1467 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1059 3448-6867 171 µM 0.497882078743988 0.28890084761733 no 1023 0.309283579751773 1493 3934407
SGTC_3107 9121808 49.47 µM 0.494720101874476 0.289922340654039 no 1024 0.310398854951453 1479 662681
SGTC_303 1348-1668 34.2 µM 0.493931113512616 0.290177491235813 no 1025 0.310677415129232 1497 5380509
SGTC_595 3909-8003 73.7 µM 0.493881767678346 0.290193452657614 no 1026 0.310694840775266 1518 699517
SGTC_1754 st042065 16.137 µM 0.493684927259159 0.29025712682511 no 1027 0.310764355862675 1432 1126236 YIL048W NEO1
SGTC_1066 ketoconazole 628 nM 0.493118525398336 0.290440383656133 no 1028 0.310964420930475 1570 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2283 7944793 200 µM 0.491798960518598 0.290867533011916 no 1029 0.311430735724516 1426 2970533
SGTC_19 0279-0214 38.434 µM 0.491137574111058 0.291081737315868 no 1030 0.311664573866097 1520 3566274 YBR002C RER2
SGTC_2575 plumbagin 510 nM 0.490277584995233 0.291360373542778 no 1031 0.311968743092473 1425 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_161 4065-0411 162.148 µM 0.488798690504928 0.291839825756714 no 1032 0.312492112597399 1552 1906281 YLR208W SEC13
SGTC_1000 4048-0884 8.67 µM 0.487965016045269 0.292110261874511 no 1033 0.312787310508786 1534 13040088
SGTC_1749 st037932 54.2 µM 0.4856615124176 0.292858102377895 no 1034 0.313603587934938 1482 594497
SGTC_2267 7931562 200 µM 0.485529945301737 0.292900842918744 no 1035 0.313650238123461 1402 934880
SGTC_1406 3909-7906 11.9 µM 0.485322280353317 0.292968310288029 no 1036 0.313723876636653 1529 X1406
SGTC_2057 5236571 38.335 µM 0.483959943891063 0.293411092622135 no 1037 0.314207148517446 1590 54684039 YBR257W POP4
SGTC_904 1141-0088 396 µM 0.483798959773193 0.293463435652671 no 1038 0.314264276697578 1421 1378119
SGTC_2628 lathosterol 100 µM 0.483432764423938 0.293582518004171 no 1039 0.314394244434694 1535 6710616
SGTC_482 fipronil 114 µM 0.48323474342656 0.293646921385157 no 1040 0.314464534381129 1528 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_956 1185-0240 191 µM 0.481083360604994 0.294347047734533 no 1041 0.315228626785707 1511 1416193
SGTC_1191 1487-1166 10.6 µM 0.480956941173028 0.294388212485519 no 1042 0.315273550979069 1597 3955771
SGTC_923 1900-2434 73.3 µM 0.480570762005664 0.294513976773736 no 1043 0.315410799862828 1459 5910570
SGTC_959 1222-0044 107 µM 0.480325018118876 0.294594019386098 no 1044 0.315498151017929 1560 6083612
SGTC_2040 5100729 123 µM 0.478341196656548 0.295240548164916 no 1045 0.316203689645343 1543 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_613 3914-0030 117 µM 0.476577978382836 0.29581572983594 no 1046 0.316831333892654 1453 1145395
SGTC_1338 1486-1223 76 µM 0.47557206823237 0.29614409948796 no 1047 0.317189639313412 1581 3444526
SGTC_3137 9097352 49.47 µM 0.473877516143333 0.296697647489698 no 1048 0.317793626685509 1595 44120435
SGTC_2737 bleomycin 30.5 nM 0.470390816525419 0.297838112104151 no 1049 0.319037912046933 1529 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2358 9037157 4 µM 0.47032877875828 0.297858422128514 no 1050 0.319060069759744 1560 2388925
SGTC_1303 1160-0052 261 µM 0.468690835467596 0.298394882946019 no 1051 0.319645319283663 1530 3562476
SGTC_513 4245-1575 41.7 µM 0.467773370167842 0.298695564104649 no 1052 0.319973333039864 1610 719745
SGTC_2768 sulfasalazine 50.2 µM 0.467275030692101 0.298858942747772 no 1053 0.320151559242119 1662 5384001 An antioxidant and salicylic acid derivative.
SGTC_398 bronopol 33.3 µM 0.466345403429109 0.299163825866935 no 1054 0.320484142178788 1571 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_702 1488-0190 94 µM 0.465564644568828 0.299419994703979 no 1055 0.320763577469911 1627 949357
SGTC_364 0083-0097 67.7 µM 0.465191370371274 0.299542501987495 no 1056 0.320897209019253 1558 5207356
SGTC_3273 9137859 49.47 µM 0.463422813492774 0.300123244700573 no 1057 0.321530664673985 1583 2377234
SGTC_3306 9127676 59.7925 µM 0.462820911214914 0.300321008005697 no 1058 0.321746370514107 1518 41905287
SGTC_1565 sinapyl alcohol 95.1 µM 0.460298921255123 0.301150282229665 no 1059 0.322650837691058 1462 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3105 9121040 49.47 µM 0.458646858770752 0.301694067799608 no 1060 0.32324389052176 1474 41448907
SGTC_1376 2910-0861 41.3 µM 0.455663433004549 0.302677195860396 no 1061 0.324316010510257 1574 1112859
SGTC_2551 apiole 73.87 µM 0.452746552337909 0.303639780536754 no 1062 0.32536562703 1530 10659 A possible DNA adduct former.
SGTC_769 0302-0231 76 µM 0.452744356591652 0.303640505658122 no 1063 0.325366417675335 1574 571869 YER009W NTF2
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.451412849453603 0.304080363719318 no 1064 0.325846012025374 1610 5377381
SGTC_466 geldanamycin 89.2 µM 0.451391416755583 0.304087446247298 no 1065 0.325853734209367 1569 5288382 HSP90 inhibitor.
SGTC_3329 9141233 27.5565 µM 0.450629423559518 0.304339297956795 no 1066 0.32612832827292 1629 4909101 YNL103W MET4
SGTC_1112 tnp00069 1.16933 µM 0.450574597509712 0.304357422479668 no 1067 0.326148089184487 1636 145826
SGTC_1539 benzyladenosine 56 µM 0.449888281589638 0.304584347037367 no 1068 0.326395498799433 1521 92208 A nucleotide analog.
SGTC_2828 7998861 71.43 µM 0.447872339764734 0.30525133593414 no 1069 0.327122665926476 1666 2988188
SGTC_775 4577-0580 57.3 µM 0.447586206652642 0.305346057637809 no 1070 0.327225929825958 1615 2006902
SGTC_35 0133-0054 64.071 µM 0.447124029210207 0.305499084708593 no 1071 0.327392755108225 1465 99677
SGTC_1401 3807-4679 7.6 µM 0.446403757745771 0.305737634525722 no 1072 0.327652809455233 1571 3291456
SGTC_2778 tioconazole 65.09 nM 0.44617549514702 0.305813251013596 no 1073 0.327735241228857 1506 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_309 k408-0051 1.48 µM 0.445021157985002 0.306195774716436 no 1074 0.328152231987699 1571 3640463
SGTC_2515 chrysin 20.77 µM 0.44408897197608 0.306504836381557 no 1075 0.328489129649483 1641 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2949 9072542 2.23 µM 0.441897818181551 0.307231844458781 no 1076 0.329281574776388 1525 16457352
SGTC_2674 ligustilide 100 µM 0.441205344548612 0.307461759738971 no 1077 0.32953217218793 1570 5319022 A signalling regulator.
SGTC_1845 st056753 3.01 µM 0.440835230221352 0.307584676232811 no 1078 0.329666143269269 1501 5375839
SGTC_2650 prasterone 100 µM 0.439948328602484 0.307879307816523 no 1079 0.329987265888763 1562 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_661 1304-0007 33.6 µM 0.439676774149845 0.307969543868685 no 1080 0.330085613337674 1537 3117130
SGTC_3245 9134821 49.47 µM 0.438862567973448 0.308240169693138 no 1081 0.330380560474898 1490 17014901
SGTC_264 promethazine 12.5 mM 0.437659087843389 0.308640373316693 no 1082 0.330816715563698 1564 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_602 3130-1533 38.1 µM 0.437580496569015 0.308666515865689 no 1083 0.330845205947091 1641 720941
SGTC_2789 5281112 71.43 µM 0.436672933743526 0.308968477189293 no 1084 0.331174280506494 1508 765948
SGTC_1772 st048439 82.2 µM 0.432283071971143 0.310430877783438 no 1085 0.332767844459267 1564 2927068 YDL195W SEC31
SGTC_2502 avocadyne acetate 18.59 µM 0.431295950879592 0.310760132967359 no 1086 0.333126597075994 1531 3952079
SGTC_291 SEC14.278 35.5 µM 0.427311055515173 0.312090837813279 no 1087 0.334576390721272 1676 1068044
SGTC_1952 st077036 64.1 µM 0.426986301076086 0.312199393853409 no 1088 0.33469465275546 1557 2937007
SGTC_2240 6690706 185.951 µM 0.425295801915178 0.31276474216153 no 1089 0.335310526755517 1506 805876
SGTC_3315 9136395 68.55 µM 0.4249856169076 0.312868524247822 no 1090 0.335423579906433 1699 16876844
SGTC_2151 5563267 85.4165 µM 0.424562658349411 0.313010062150883 no 1091 0.335577759656464 1588 5310824
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.423592041108924 0.313334971500011 no 1092 0.335931680341638 1656 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2034 5197015 53.07 µM 0.423389153224396 0.313402905543995 no 1093 0.336005678696099 1685 780676
SGTC_2669 eugenol 100 µM 0.423130662036789 0.31348946671298 no 1094 0.336099966193035 1658 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_723 4182-0001 115 µM 0.421610459551858 0.313998745974879 no 1095 0.336654685238457 1567 744821 YLR208W SEC13
SGTC_1579 chlormadinone acetate 49.4 µM 0.420211048161221 0.314467872703815 no 1096 0.337165642249851 1700 45114258 A steroidal progestin.
SGTC_862 0452-0056 10.2 µM 0.420112619203448 0.314500880478933 no 1097 0.337201592229939 1585 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1026 k007-1105 30.6 µM 0.418916508782458 0.31490210997227 no 1098 0.337638575730603 1593 7066794
SGTC_752 1896-0090 130 µM 0.414365815155631 0.316430612669289 no 1099 0.339303110208677 1599 772567
SGTC_1012 4112-3522 18 µM 0.413508988148287 0.316718758851373 no 1100 0.339616869277617 1717 3112398
SGTC_1866 st057638 64 µM 0.41337648414786 0.316763329149483 no 1101 0.339665400475916 1609 688802
SGTC_946 3434-1334 87.4 µM 0.412970469373966 0.316899916677094 no 1102 0.339814124863901 1683 4047976
SGTC_3258 9138477 49.47 µM 0.411603518169999 0.317359956441751 no 1103 0.34031502625619 1647 4970355
SGTC_1550 gossypolone 36.6 µM 0.409442080092265 0.318087952208598 no 1104 0.341107631959569 1610 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_660 4031-1742 102 µM 0.408285544112391 0.318477775134874 no 1105 0.341532025507637 1613 6738706
SGTC_99 0109-0120 622.8 µM 0.407762388263186 0.31865417652244 no 1106 0.341724064625339 1699 759414
SGTC_2487 5918373 44.05 µM 0.405240155083002 0.319505217167546 no 1107 0.342650495630115 1678 2876279
SGTC_2435 5706476 10.6 µM 0.404798082651422 0.319654477399835 no 1108 0.342812969137609 1750 5725375
SGTC_2647 atorvastatin 60.16 µM 0.404615422641705 0.319716158800584 no 1109 0.342880110094409 1676 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2651 TUB2.036 5 µM 0.404259281311941 0.319836436441627 no 1110 0.343011032434323 1691 15992207 YFL037W TUB2
SGTC_2021 4019055 173 µM 0.404257347712802 0.319837089517087 no 1111 0.343011743302821 1629 44827708 YER133W GLC7
SGTC_1367 1812-0510 76.9 µM 0.403993226503626 0.319926302024057 no 1112 0.343108850060116 1647 1142582 YDR527W RBA50
SGTC_3151 9099821 49.47 µM 0.402691245778964 0.320366225603407 no 1113 0.343587687394802 1580 17174189
SGTC_2629 bisabolol 100 µM 0.400437849958204 0.321128217441053 no 1114 0.344417025448868 1701 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3176 9106582 49.47 µM 0.399851047182271 0.321326770204226 no 1115 0.344633114898747 1630 17018027
SGTC_458 nppb 133 µM 0.399034051354993 0.321603296991038 no 1116 0.344934057109605 1763 4549 A chloride channel blocker.
SGTC_2012 4023501 200 µM 0.39869450968547 0.321718250009071 no 1117 0.345059156905133 1582 3477460
SGTC_1625 st003711 30.1 µM 0.397363650420982 0.322168981542656 no 1118 0.345549658193938 1695 24207034 YER133W GLC7
SGTC_31 0508-1974 57.237 µM 0.395112561600044 0.3229319690757 no 1119 0.346379909363582 1686 6810525
SGTC_1803 st050068 52.4 µM 0.395087912276671 0.322940327889227 no 1120 0.34638900467288 1651 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1645 Cervolide 78 µM 0.394951885917189 0.322986457294262 no 1121 0.346439198386516 1626 23173 A fragrance.
SGTC_637 1181-0519 7.26 µM 0.393649648365145 0.323428211220502 no 1122 0.346919860288951 1615 6252091 YGR060W ERG25
SGTC_24 0417-1663 219 µM 0.392526271266199 0.323809490979119 no 1123 0.347334702006784 1628 4329390
SGTC_1515 3460-0031 42.1 µM 0.392463565671855 0.323830779023002 no 1124 0.347357863381396 1624 2876596
SGTC_469 w7 172 µM 0.392405149294426 0.323850611430839 no 1125 0.347379440973857 1677 45115570 A P450 inhibitor.
SGTC_2201 6605497 169.863 µM 0.389405792571707 0.324869566463596 no 1126 0.348487993845549 1707 670741
SGTC_890 0929-0006 47.2 µM 0.388935533382244 0.325029444181266 no 1127 0.348661917870589 1593 1378169
SGTC_1004 4084-0029 199 µM 0.385265438880093 0.326278300291865 no 1128 0.350020382357466 1771 716894 YLR208W SEC13
SGTC_2150 5556613 200 µM 0.385020100937814 0.326361853340108 no 1129 0.35011126150769 1672 743190
SGTC_1420 4'-methoxyflavone 42 µM 0.3831838882409 0.326987476045681 no 1130 0.350791711673971 1765 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2106 5357045 167.29 µM 0.381705070901024 0.327491683124966 no 1131 0.351340069176795 1728 668842
SGTC_1254 0550-0035 264 µM 0.380720773472136 0.327827456771483 no 1132 0.351705226361087 1727 15121435
SGTC_217 ketoconazole 989 nM 0.38039673853171 0.327938025375956 no 1133 0.351825467633837 1644 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1424 4048-1941 275 µM 0.379838089965506 0.328128685270042 no 1134 0.352032802961674 1772 X1424
SGTC_1741 st038134 10.228 µM 0.379627292639864 0.328200639449272 no 1135 0.352111049151559 1772 1272587
SGTC_1618 st003135 44.5 µM 0.378942252698568 0.328434517006537 no 1136 0.352365373426482 1713 1270615
SGTC_3303 9125618 40.5795 µM 0.378800548182611 0.328482904342643 no 1137 0.352417990134544 1748 22695467
SGTC_2298 7976326 193.81 µM 0.378388922399228 0.328623477044449 no 1138 0.352570848093568 1687 2235818
SGTC_500 h-89 112 µM 0.37830312503191 0.328652780421232 no 1139 0.352602712096305 1798 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1988 st071872 53.4 µM 0.377594395036385 0.3288948815398 no 1140 0.352865964543191 1775 16414116
SGTC_1176 0848-0131 83.3 µM 0.376771852208856 0.329175950982674 no 1141 0.353171580245988 1796 6769040
SGTC_1971 st069429 63.5 µM 0.37603734819108 0.329427018502642 no 1142 0.35344456520587 1776 1246522 YGL099W LSG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.375897055180227 0.329474982089178 no 1143 0.353496714933982 1613 16623 A steroid.
SGTC_2421 5690543 90.72 µM 0.375444277185316 0.329629797650074 no 1144 0.353665040359543 1691 3397993
SGTC_1832 st054113 55 µM 0.375313779143778 0.329674423454881 no 1145 0.353713559820683 1758 1251267
SGTC_1970 st070122 35.8 µM 0.375244412519456 0.329698145422094 no 1146 0.353739351452755 1710 102928
SGTC_454 lyso-paf C-16 6.67 µM 0.374087761809889 0.330093797210694 no 1147 0.354169511726489 1564 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1485 3909-9022 254 µM 0.37393815332681 0.330144987196939 no 1148 0.354225164971594 1671 714516
SGTC_570 0987-0065 62.6 µM 0.373310574823009 0.330359753874991 no 1149 0.354458653428034 1739 3104428
SGTC_2036 5160441 105 µM 0.373032237726329 0.330455022855534 no 1150 0.354562225319165 1695 134534 YIL048W NEO1
SGTC_1492 4158-0558 28.5 µM 0.371385973687022 0.331018729216328 no 1151 0.355175035567092 1776 3967268
SGTC_3342 9147791 14.508 µM 0.371324852026837 0.331039665608389 no 1152 0.355197794901219 1664 1838168
SGTC_2641 levomentholum 100 µM 0.370907330797961 0.331182695945806 no 1153 0.355353277415118 1703 16666
SGTC_420 mitomycin C 81.9 mM 0.369374362312327 0.331708056426859 no 1154 0.355924352432793 1651 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3095 9117207 49.47 µM 0.368916828953229 0.331864920963011 no 1155 0.3560948595471 1807 17015229
SGTC_1133 3473-0247 50 µM 0.36877811638404 0.331912484156784 no 1156 0.356146558688895 1601 711311
SGTC_426 0988-0037 14.6 µM 0.368040909946245 0.332165310530408 no 1157 0.35642136502605 1816 5383008
SGTC_2107 5363541 170.161 µM 0.367585501642944 0.332321531879055 no 1158 0.356591163547899 1688 244052
SGTC_1931 st074438 57.1 µM 0.36743724352858 0.332372396007108 no 1159 0.356646447569818 1642 2787313
SGTC_797 k781-0471 270 µM 0.364180195502774 0.333490595699007 no 1160 0.357861727378985 1743 23738129
SGTC_871 0574-0004 149 µM 0.363271826064485 0.33380271885688 no 1161 0.358200918693473 1678 9551173
SGTC_2348 9022543 33.42 µM 0.36243520540251 0.334090290322024 no 1162 0.358513417565854 1714 3162678 YDL140C RPO21
SGTC_1250 0485-0349 40.2 µM 0.362143365256999 0.334190627411601 no 1163 0.358622449510132 1658 6842794 YDL195W SEC31
SGTC_1297 1068-0111 14.1 µM 0.361911452488488 0.334270369416783 no 1164 0.358709100708463 1620 767057
SGTC_380 3970-0968 6 µM 0.360481657815544 0.334762162014281 no 1165 0.359243485436796 1671 2891601
SGTC_1387 3342-1166 1.8 µM 0.359850832960376 0.334979230921115 no 1166 0.359479343417483 1713 3418228
SGTC_1729 st035615 45.989 µM 0.358105365231353 0.33558013926995 no 1167 0.360132232043069 1676 17385451
SGTC_551 k048-0028 34.9 µM 0.357853072740985 0.33566703029224 no 1168 0.360226635339691 1779 6836383
SGTC_1938 st074717 56.4 µM 0.356467876014267 0.336144256685097 no 1169 0.360745102683844 1642 17250979
SGTC_1397 3532-0190 20.1 µM 0.356084790391255 0.336276283576835 no 1170 0.360888533610451 1714 5322280
SGTC_2191 5911152 200 µM 0.355102021325853 0.336615078107122 no 1171 0.361256581204206 1701 2875902
SGTC_3261 9137475 49.47 µM 0.354911636335687 0.336680725753909 no 1172 0.361327895358653 1706 17027690
SGTC_127 0180-0333 59.125 µM 0.354672058911668 0.336763342773938 no 1173 0.361417642796142 1721 771601
SGTC_2884 9058502 51.95 µM 0.354662505267193 0.336766637461567 no 1174 0.361421221818677 1655 6471554
SGTC_2697 mebhydrolin 72.4 µM 0.35226428110267 0.33759408920661 no 1175 0.362320036507546 1837 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1340 1486-1359 257 µM 0.350017249333778 0.338370088730513 no 1176 0.363162876197929 1727 4309068
SGTC_1200 1643-0193 18.4 µM 0.3496565401261 0.338494721657817 no 1177 0.363298236570786 1788 5403974
SGTC_1146 3579-1023 7 µM 0.348932682701446 0.338744883608833 no 1178 0.363569924076713 1820 X1146
SGTC_235 0330-0087 5 mM 0.34861587103164 0.33885439472382 no 1179 0.363688855518873 1701 46494818 YHR062C RPP1
SGTC_2879 9041815 71.43 µM 0.346584423772479 0.339556920922447 no 1180 0.364451774726537 1708 4942971
SGTC_670 4204-0025 119 µM 0.345445368339347 0.339951079560493 no 1181 0.364879787438321 1782 719039
SGTC_3082 9117008 49.47 µM 0.345200473721264 0.340035845745796 no 1182 0.364971831325001 1698 41448529
SGTC_2067 5224629 34.075 µM 0.344970133164883 0.340115581665886 no 1183 0.36505841215472 1662 2835000
SGTC_3255 9139072 49.47 µM 0.341858106514614 0.341193557163076 no 1184 0.36622883916935 1724 17646060
SGTC_1009 4106-0057 9.87 µM 0.341622880798602 0.341275089886724 no 1185 0.366317357860494 1831 2928005
SGTC_2461 5755302 26.15 µM 0.340903732397667 0.34152440333755 no 1186 0.366588027452961 1830 2788904
SGTC_1724 st037281 8.293 µM 0.340362526775451 0.341712073429721 no 1187 0.366791767576229 1672 574124 YDL195W SEC31
SGTC_2954 9074818 52.69 µM 0.338700363519315 0.342288694633045 no 1188 0.36741773339258 1778 16648742
SGTC_2804 7954240 19.48 µM 0.337881598479621 0.342572867811959 no 1189 0.367726207590927 1814 828705
SGTC_1051 3253-3903 78 µM 0.335717855697213 0.343324278272931 no 1190 0.368541819823276 1688 5509239
SGTC_2229 7354935 190 µM 0.335467632546513 0.34341121416982 no 1191 0.368636178510504 1778 318112
SGTC_1164 k060-0068 93.7 µM 0.335145105726441 0.343523283003231 no 1192 0.368757814461825 1730 5963676
SGTC_3106 9121286 49.47 µM 0.334778272850776 0.343650763642918 no 1193 0.368896175731392 1811 15943471
SGTC_253 dyclonine 31.25 µM 0.334519802434634 0.343740597171981 no 1194 0.368993675277062 1789 3180 An oral anasthetic.
SGTC_799 1310-0557 151 µM 0.334062610349682 0.343899519665099 no 1195 0.369166156740694 1748 5354492
SGTC_373 0844-0104 25.9 µM 0.333816250212031 0.343985167247417 no 1196 0.369259110125845 1835 5375804
SGTC_44 0929-0055 61.211 µM 0.332742357696176 0.344358601529543 no 1197 0.369664386430648 1669 1379590
SGTC_107 0358-0022 2.6945 µM 0.331418903114499 0.344819027037518 no 1198 0.370164044165419 1813 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2866 9034245 58.44 µM 0.331225260964918 0.344886413803457 no 1199 0.370237170325539 1859 6462273
SGTC_1274 0865-0114 173 µM 0.330994097886292 0.344966864159651 no 1200 0.370324471863916 1747 870624
SGTC_1029 k015-0030 64.7 µM 0.330689467726522 0.345072893545216 no 1201 0.370439529337134 1767 2208316
SGTC_2342 7990637 118.86 µM 0.32952604719128 0.34547794486038 no 1202 0.370879054748014 1753 2033102 YER133W GLC7
SGTC_277 nystatin 15.5 µM 0.329415370306096 0.345516486859562 no 1203 0.370920875848328 1680 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2165 5727197 32.143 µM 0.329356061917644 0.345537141007939 no 1204 0.370943287135993 1783 1361712
SGTC_41 0478-0632 82.643 µM 0.328555547218444 0.345815965251369 no 1205 0.371245826191151 1898 3750424
SGTC_562 3772-2733 112 µM 0.328428925406182 0.345860076080457 no 1206 0.371293687751253 1836 2876874 YIL048W NEO1
SGTC_1842 st055362 61.2 µM 0.326329942989479 0.346591596161813 no 1207 0.372087367942837 1795 676032
SGTC_706 4262-0057 46.9 µM 0.325391585915302 0.346918809970498 no 1208 0.372442361403188 1692 883298
SGTC_1241 0364-0022 50.8 µM 0.325075371222529 0.347029102701822 no 1209 0.37256201423071 1781 4563895
SGTC_413 propylparaben 100 µM 0.322929673327311 0.347777844007129 no 1210 0.373374251592889 1695 7175 A pharmaceutical preservative.
SGTC_3016 9080866 49.47 µM 0.32163321845969 0.348230530061058 no 1211 0.373865287635819 1702 17066299
SGTC_2951 9072950 58.06 µM 0.320950331570643 0.348469062228428 no 1212 0.374124015420314 1828 16488155
SGTC_223 busulfan 5 mM 0.320694269220561 0.348558520178955 no 1213 0.374221045299116 1812 2478 A DNA alkylator.
SGTC_2716 st080858 38.6235 µM 0.319928923671768 0.3488259515158 no 1214 0.374511105681115 1833 5296050
SGTC_27 0485-0001 32.618 µM 0.317392008017685 0.349712951400449 no 1215 0.375473085327022 1853 2054479
SGTC_1915 st067105 30.6 µM 0.316601161550065 0.349989628768635 no 1216 0.375773127150283 1710 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_516 3992-2719 87.3 µM 0.315828155803421 0.350260141555933 no 1217 0.376066472936811 1630 5350887 YDR037W KRS1
SGTC_3057 9095946 49.47 µM 0.315603969524714 0.350338609597747 no 1218 0.376151562165608 1772 24540043
SGTC_3132 9126706 49.47 µM 0.315201805848503 0.350479387993589 no 1219 0.376304217265924 1791 850858
SGTC_843 0310-0051 143 µM 0.314710141408239 0.350651524258921 no 1220 0.376490871758926 1774 2065037
SGTC_3186 9110464 49.47 µM 0.314003009308722 0.350899151509423 no 1221 0.376759376591815 1833 17018021
SGTC_3161 9100388 49.47 µM 0.313859163226547 0.350949532046185 no 1222 0.376814003629544 1804 25236368
SGTC_1237 0330-0133 46.1 µM 0.312658552095585 0.35137013526376 no 1223 0.377270044228623 1751 X1237 YHR072W ERG7
SGTC_764 1951-2361 146 µM 0.312455625468944 0.351441243387883 no 1224 0.377347140889216 1696 5438930
SGTC_2037 5169046 200 µM 0.312291806387718 0.35149865151363 no 1225 0.377409383227763 1811 5718022
SGTC_1878 temozolomide 1 mM 0.312253403460379 0.351512109777244 no 1226 0.377423974711696 1918 5394 DNA alkylating agent.
SGTC_2975 9084847 53.72 µM 0.312112451010436 0.351561508003438 no 1227 0.377477532165207 1742 27211724
SGTC_1660 st012960 28.1 µM 0.311355073134297 0.35182698172311 no 1228 0.377765352020156 1768 24207266
SGTC_1863 st057641 20.1 µM 0.311075695983558 0.351924926376481 no 1229 0.377871538481686 1896 3921635
SGTC_3099 9120367 49.47 µM 0.310670165261417 0.352067115707895 no 1230 0.378025690169801 1749 24824940
SGTC_468 gf-109203x 121 µM 0.309822542717423 0.352364380403535 no 1231 0.378347953969269 1861 2396 A protein kinase C inhibitor.
SGTC_2746 daunorubicin 9.88 µM 0.309362527637041 0.352525747350708 no 1232 0.378522885905473 1879 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2862 9027634 71.43 µM 0.308232757849378 0.352922167610855 no 1233 0.378952613965386 1690 5012562
SGTC_3175 9106517 49.47 µM 0.308073182004108 0.352978173403148 no 1234 0.379013323554891 1749 41468073
SGTC_3021 9087658 49.47 µM 0.306923219166811 0.353381866077148 no 1235 0.379450907582588 1866 25237042
SGTC_2138 5575593 77.673 µM 0.306534620684178 0.353518320296593 no 1236 0.379598812080067 1730 762213
SGTC_357 1325-0123 420 µM 0.303507020974149 0.354582088828916 no 1237 0.380751748850379 1899 1098503
SGTC_1928 4'-methoxychalcone 40.3 µM 0.302932378846186 0.35478412182468 no 1238 0.380970697630553 1949 641818
SGTC_1450 4112-4260 37.6 µM 0.301781670622652 0.355188811207792 no 1239 0.381409252270182 1891 1633175
SGTC_533 1222-0222 6.71 µM 0.301005203592504 0.35546197709405 no 1240 0.381705263272644 1894 3982874
SGTC_3348 9149464 3.537 µM 0.300440042226154 0.35566085105527 no 1241 0.381920762150261 1795 1951442
SGTC_446 go6976 132 µM 0.299736795271635 0.355908370657733 no 1242 0.382188964849558 1901 3501 A protein kinase C inhibitor.
SGTC_2857 9024691 58.44 µM 0.299221025012704 0.35608994330474 no 1243 0.382385704066439 1777 16478292
SGTC_2846 9008642 19.48 µM 0.298212698861421 0.356445010423383 no 1244 0.382770415105844 1745 2992898
SGTC_2285 7945142 200 µM 0.298106780318944 0.356482315298561 no 1245 0.382810833386847 1764 2970608
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.297685251433917 0.356630792826301 no 1246 0.382971700517069 1839 6708630 An antioxidant.
SGTC_2200 6600604 21.907 µM 0.297472685014296 0.356705674553447 no 1247 0.383052829425063 1773 2904777
SGTC_2511 berberine 10.47 µM 0.297270235756087 0.356776997397535 no 1248 0.383130101748527 1753 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_63 0099-0242 26.702 µM 0.297032718445388 0.356860681094753 no 1249 0.383220765032922 1917 3898502 YLR359W ADE13
SGTC_1530 rhein 70.4 µM 0.293420579653822 0.358134181000051 no 1250 0.384600348534717 1828 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_201 4262-0159 12.803 µM 0.293344923349106 0.35816087141785 no 1251 0.384629259632406 1917 1341029
SGTC_1602 st001878 87.6 µM 0.291549253679013 0.358794560147069 no 1252 0.385315640037736 1876 595405 YLR310C CDC25
SGTC_3027 9089541 49.47 µM 0.289881314392785 0.359383521470049 no 1253 0.385953518556402 1785 9943819
SGTC_2899 9053889 58.44 µM 0.289649466592335 0.359465415081646 no 1254 0.386042209749684 1939 6470052
SGTC_224 benfluorex 43.875 µM 0.289096948364007 0.359660602376267 no 1255 0.386253594398458 1896 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1891 st059073 26.2 µM 0.289008243852808 0.359691942299549 no 1256 0.386287534474894 1946 688754
SGTC_3226 9131256 49.47 µM 0.288467979259291 0.359882841920546 no 1257 0.386494269027268 1817 17178073
SGTC_93 0109-0045 59.227 µM 0.288226427937748 0.35996820410691 no 1258 0.386586710098315 1917 88733
SGTC_2839 9003951 25.97 µM 0.287968262542609 0.360059445286975 no 1259 0.386685516447929 1917 2990634
SGTC_757 1066-0008 322 µM 0.287632296827467 0.360178194705215 no 1260 0.386814109923789 1874 6842497
SGTC_154 3389-1638 511.116 µM 0.286805693139777 0.360470420941534 no 1261 0.387130551752287 1677 5238686
SGTC_2323 6148992 148.28 µM 0.285920233425166 0.360783544768166 no 1262 0.387469608172593 1765 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2760 etidronate 98.04 µM 0.28580052286523 0.360825885006551 no 1263 0.387515453817891 1772 3305 A chelator and antioxidant.
SGTC_2900 5328528 85.29 µM 0.285390779614225 0.360970819356764 no 1264 0.387672385375083 1755 795359
SGTC_891 0929-0073 133 µM 0.284745556207674 0.361199088195194 no 1265 0.387919542963816 1879 5603632
SGTC_818 4072-2707 53.5 µM 0.282726342474599 0.361913770034088 no 1266 0.38869331069503 1760 882871
SGTC_645 0845-0943 5.41 µM 0.282606163155946 0.361956321596982 no 1267 0.388739377669784 1817 1885106
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.282062100605501 0.36214897767938 no 1268 0.388947946560363 1840 4000243
SGTC_1227 3909-8010 46.6 µM 0.280787450409699 0.3626004762889 no 1269 0.389436714842272 1825 15982272
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.280733607012195 0.362619552571677 no 1270 0.389457365104468 1834 88881 An O-methylated flavonoid and antioxidant.
SGTC_3011 9081274 71.4286 µM 0.277044361029233 0.363927432640174 no 1271 0.390873021783561 1795 6625322
SGTC_337 1315-0038 354 µM 0.274562927524664 0.364808022928296 no 1272 0.391826025785406 1822 1626437
SGTC_3100 9120536 49.47 µM 0.273891294412379 0.36504648936483 no 1273 0.392084080961474 1936 16421196
SGTC_1305 1181-0477 144 µM 0.273460624116036 0.365199428316715 no 1274 0.392249578284231 1935 6252086
SGTC_913 3487-1245 167 µM 0.273078384567672 0.365335186580341 no 1275 0.392396481041423 1732 4016153
SGTC_2125 5246583 200 µM 0.272796080301818 0.365435462124162 no 1276 0.392504986398258 1986 835267
SGTC_1282 0886-0010 32.4 µM 0.27256531927406 0.36551743614779 no 1277 0.392593687006439 1958 2836211 YNL267W PIK1
SGTC_3294 9122953 26.2835 µM 0.271501996490715 0.365895243226614 no 1278 0.393002482188438 1801 16459826
SGTC_2695 st077686 51.995 µM 0.270509279087967 0.366248081080374 no 1279 0.393384239629183 1784 2876092
SGTC_1590 st077108 57.8 µM 0.270307149936265 0.366319936962657 no 1280 0.393461982590863 1947 5489485
SGTC_130 0136-0219 337.655 µM 0.268532884231074 0.366950880265203 no 1281 0.394144583044775 1964 234244
SGTC_2434 5670830 169.91 µM 0.267711246696531 0.367243183163288 no 1282 0.394460796052619 1824 1549830
SGTC_830 4076-0286 57.8 µM 0.266693433150359 0.367605383651364 no 1283 0.394852605220574 1852 6866659
SGTC_1619 st003326 88.7 µM 0.266309433186394 0.367742065012873 no 1284 0.395000454358108 1918 2849032
SGTC_981 1488-1094 54.9 µM 0.266197683894553 0.367781844323908 no 1285 0.39504348333991 1832 3449522
SGTC_203 k066-0004 30.888 µM 0.265244729477786 0.368121124364244 no 1286 0.395410469678567 1983 6795412
SGTC_257 daunorubicin 18.5 µM 0.26431584529399 0.368451933718156 no 1287 0.39576827577032 1967 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2552 juarezic acid 87.02 µM 0.264025892626873 0.368555216366702 no 1288 0.395879983514333 1950 1549512
SGTC_732 3970-1727 52.7 µM 0.263687679098038 0.368675701784294 no 1289 0.396010295139519 1964 1275699
SGTC_1411 3909-8223 150 µM 0.261930758902863 0.369301795711796 no 1290 0.396687412539763 1947 X1411
SGTC_839 0122-0028 230 µM 0.261599651301954 0.369419827700947 no 1291 0.396815056439308 1879 759448
SGTC_287 k060-0039 29.6 µM 0.261216834322529 0.369556308196308 no 1292 0.396962648384803 1959 5861974
SGTC_580 1123-0028 41 µM 0.257161470474966 0.371003117832565 no 1293 0.398527063038595 1910 1677248 YPR107C YTH1
SGTC_3215 9129942 49.47 µM 0.257144722920813 0.371009096563056 no 1294 0.398533527048387 2002 17682944
SGTC_228 caffeine 993.056 µM 0.255243964483649 0.371687852696213 no 1295 0.399267338280239 1947 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_514 4466-0038 2.65 nM 0.255102022731249 0.37173855578428 no 1296 0.399322150963676 1866 5722064
SGTC_122 0236-0016 402.397 µM 0.252441670885064 0.372689272216331 no 1297 0.400349847065797 1864 6808838
SGTC_2787 5284540 71.43 µM 0.252111585804357 0.372807287284491 no 1298 0.40047740748845 1838 736958
SGTC_1330 1469-0054 61.8 µM 0.250087361455153 0.3735312674031 no 1299 0.401259894796654 2000 7102664
SGTC_3168 9103419 49.47 µM 0.249183349265518 0.373854739046471 no 1300 0.401609479320265 1969 16649256
SGTC_2588 indole-3-carbinol 100 µM 0.247494891766264 0.374459137010283 no 1301 0.402262622170147 1987 3712 Induces cell cycle arrest.
SGTC_2864 9034755 47.6 µM 0.247079440969842 0.374607898581699 no 1302 0.402423372140042 2028 4930451
SGTC_1298 1079-1278 263 µM 0.245803538642932 0.37506488091438 no 1303 0.402917158825838 1864 2840950
SGTC_2115 tiliquinol 12.7705 µM 0.242694027612627 0.376179329574328 no 1304 0.404121217216298 1907 71208 A bioactive hydroxyquinoline.
SGTC_2853 9015042 58.44 µM 0.242614584277408 0.376207815638488 no 1305 0.404151991054298 1832 6457456
SGTC_2462 5162487 171.77 µM 0.242575807073044 0.376221720258517 no 1306 0.404167012333508 1996 2259986
SGTC_2791 5663188 71.43 µM 0.241410295793002 0.376639720897831 no 1307 0.404618566904597 1967 54690634
SGTC_3230 9131665 49.47 µM 0.240720219497184 0.376887279072731 no 1308 0.404885983408859 1907 15943720
SGTC_1423 4048-0112 5.59 µM 0.238249591035683 0.377774007470673 no 1309 0.405843758089107 1981 X1423
SGTC_1463 k081-0032 34.1 µM 0.237775892967989 0.377944095283958 no 1310 0.406027458560081 1918 977755
SGTC_225 nsc-122657 1.016 µM 0.236487069547852 0.37840698476694 no 1311 0.406527369886495 1944 275685
SGTC_3144 9087057 49.47 µM 0.23489709803534 0.378978274016079 no 1312 0.407144300997738 2076 17249618
SGTC_3246 9135460 32.98 µM 0.234688737476966 0.37905315922714 no 1313 0.407225164909555 1955 41446951
SGTC_564 3555-0129 330 µM 0.234461468014194 0.379134845513206 no 1314 0.407313371801463 2012 563260
SGTC_2720 fluspirilene 36.88 µM 0.232943330418678 0.379680640128421 no 1315 0.407902705495621 1961 3396 An atypical antipsychotic.
SGTC_614 0462-0418 107 µM 0.232875132688197 0.379705163933602 no 1316 0.407929184427635 1931 5188303
SGTC_3345 9148410 3.559 µM 0.230776533758698 0.380460053162434 no 1317 0.408744206266715 1990 4903596
SGTC_77 0828-0286 12.516 µM 0.230514293525351 0.380554415943532 no 1318 0.408846078948466 2010 745345
SGTC_2184 6075246 200 µM 0.227080286389919 0.381790740171275 no 1319 0.41018065642072 1947 2267320
SGTC_207 4185-0010 4.486 µM 0.226970375059641 0.3818303308597 no 1320 0.41022338915205 2003 3761753
SGTC_836 0330-0104 1.35 µM 0.224444972282728 0.382740335031348 no 1321 0.411205540169594 1954 46494820
SGTC_2847 9005661 71.43 µM 0.222786771089057 0.383338204220692 no 1322 0.411850732206721 2016 2991449
SGTC_2335 9018011 154.17 µM 0.222505504761772 0.383439643209577 no 1323 0.411960194246087 2010 6458208
SGTC_1668 st014914 51.6 µM 0.21974101162602 0.384437084700974 no 1324 0.413036431270152 1982 2839556
SGTC_3314 9135860 59.4275 µM 0.218098628380048 0.38503002691184 no 1325 0.413676133038444 2051 25252478
SGTC_1702 st027038 51 µM 0.217421609570653 0.385274526317752 no 1326 0.413939895984951 1950 5521182
SGTC_1455 4262-0120 131 µM 0.216585515841524 0.385576537171536 no 1327 0.414265687251264 1988 1529587
SGTC_1491 4138-0063 26.5 µM 0.215641493093433 0.385917617164206 no 1328 0.414633604914305 2030 23883227
SGTC_39 0986-0283 58.349 µM 0.212292725713867 0.387128252822796 no 1329 0.41593933507015 2034 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3195 9113082 49.47 µM 0.211079623994407 0.387567081205904 no 1330 0.416412569861564 2086 17018038
SGTC_1759 st043059 70 µM 0.209198706496738 0.388247769706958 no 1331 0.41714656107589 1860 669426
SGTC_526 4469-0568 170 µM 0.206804255806174 0.389114798262195 no 1332 0.41808136617456 1859 2901964
SGTC_731 3966-0296 387 µM 0.206261366078689 0.389311455150707 no 1333 0.418293377516554 1935 660956
SGTC_1986 st071812 45 µM 0.206182794442938 0.389339919364272 no 1334 0.418324063575926 1995 11838594
SGTC_827 3253-0474 693 µM 0.204892157596576 0.389807564352447 no 1335 0.4188281912856 2053 5402065
SGTC_2816 7982706 58.44 µM 0.203333551701987 0.390372516986207 no 1336 0.419437166388208 1918 2981853
SGTC_1220 1838-0075 193 µM 0.200995897949679 0.39122028726092 no 1337 0.420350890789632 1989 5529645
SGTC_2078 5212016 200 µM 0.199608058805463 0.39172384397129 no 1338 0.420893562304837 2102 1899708
SGTC_577 r071-0003 38.6 µM 0.199214672386826 0.391866611403403 no 1339 0.421047411273244 1980 4568517 YMR134W ERG29
SGTC_2171 5739187 198.077 µM 0.198935945613462 0.39196777547915 no 1340 0.421156425453669 1925 2262761
SGTC_2831 7999036 19.48 µM 0.194836407176466 0.393456546109092 no 1341 0.42276050981352 2071 2988270
SGTC_987 1497-1013 404 µM 0.194122705228384 0.39371589097008 no 1342 0.423039901790996 2021 1676435
SGTC_205 1486-1330 71.903 µM 0.194040414649653 0.393745796736846 no 1343 0.423072118468938 1969 4118834
SGTC_2241 6772625 37.8075 µM 0.193808310958435 0.393830150459751 no 1344 0.423162989599223 2114 2285411
SGTC_1583 clindamycin 39.6 µM 0.192972521449757 0.394133943685566 no 1345 0.42349024414965 1873 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3250 9135583 49.47 µM 0.192349592469067 0.394360408161818 no 1346 0.423734187206966 2078 7699353
SGTC_2192 5915882 198.485 µM 0.191510615164312 0.394665472965345 no 1347 0.424062782378657 2003 2876149
SGTC_1312 1218-2183 165 µM 0.189332892598014 0.395457626789433 no 1348 0.424915958474833 2080 6744073
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.188907130099881 0.39561254991743 no 1349 0.425082802591747 1942 688667
SGTC_1969 st069479 40.1 µM 0.188067473208565 0.395918126022246 no 1350 0.425411879357036 2069 3895485
SGTC_1997 st073024 93.8 µM 0.18799310117734 0.395945195302387 no 1351 0.425441029613735 2094 686268
SGTC_682 0kpi-0099 17 µM 0.184793778528806 0.397110130171274 no 1352 0.426695393916991 1946 1714895 YML126C ERG13
SGTC_2140 5586273 200 µM 0.184640209770823 0.397166070694277 no 1353 0.426755622659179 2070 854421
SGTC_2208 7283366 200 µM 0.183165619047097 0.397703327689037 no 1354 0.427334034992117 2077 898663
SGTC_1972 st070201 17.4 µM 0.182543109628629 0.397930193037005 no 1355 0.427578263025085 2099 2829099
SGTC_2810 7959871 45.46 µM 0.17951888782985 0.399032820617846 no 1356 0.428765143943041 2028 2974535
SGTC_884 0851-0618 334 µM 0.179035508483494 0.39920913508896 no 1357 0.428954910191228 2080 9642473
SGTC_2038 4100038 30.985 µM 0.178792746932072 0.399297691055245 no 1358 0.429050220313858 2009 3596803
SGTC_1170 0310-0127 64.8 µM 0.178576543011252 0.399376563537983 no 1359 0.429135107181744 2007 774975
SGTC_2101 5377231 179.231 µM 0.177994672834637 0.399588853649754 no 1360 0.42936357969997 2041 2844213
SGTC_804 1595-0054 20.9 µM 0.177726009376142 0.39968688312391 no 1361 0.429469078948093 1959 761523 Stimulates phospholipase C.
SGTC_1135 dihydrocapsaicin 536.708 nM 0.177445877410844 0.39978910394181 no 1362 0.429579087034597 1897 107982 A Capsaicinoid.
SGTC_1188 1403-0014 4.57 µM 0.177283472166024 0.399848369146033 no 1363 0.42964286623181 1969 9614867
SGTC_3094 9117742 49.47 µM 0.175350179556923 0.400554046484007 no 1364 0.430402242462924 2105 17149698
SGTC_1062 mesoridazine 14.2 µM 0.172661894926186 0.40153584513138 no 1365 0.431458598654206 2073 4078 A neuroleptic.
SGTC_619 1652-1634 108 µM 0.169997832016113 0.402509411272071 no 1366 0.432505920817606 1980 5400454
SGTC_703 3875-0075 71.8 µM 0.168635501519298 0.403007501116243 no 1367 0.433041677141259 2034 2850814
SGTC_2304 7443016 91.4 µM 0.167739945927326 0.403335016394678 no 1368 0.433393934548157 2031 939854
SGTC_1343 1487-0095 224 µM 0.167165122538214 0.403545271858008 no 1369 0.433620063206512 2117 4560101 YGL055W OLE1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.166841290670975 0.403663733424129 no 1370 0.433747464370537 2069 688751
SGTC_2289 7946404 165.07 µM 0.165382640083752 0.40419743464942 no 1371 0.434321408364495 1999 1246120 YPR165W RHO1
SGTC_2594 a-mangostin 100 µM 0.165054973056344 0.404317348308938 no 1372 0.434450356563786 2095 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3283 9109332 35.8195 µM 0.164734075086763 0.404434793464144 no 1373 0.434576647666525 2087 17027281
SGTC_693 4161-2696 114 µM 0.163656321614375 0.404829302449344 no 1374 0.43500085207038 2084 805759
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.16260680146215 0.405213569689641 no 1375 0.435414015740337 2094 66535 A nucleotide analog.
SGTC_1900 st060200 72.8 µM 0.161579010899977 0.405589969524148 no 1376 0.435818693486051 1971 688945
SGTC_435 c-PAF 6.7 µM 0.159338863916185 0.406410663437057 no 1377 0.436700951449005 2131 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1877 wortmannin 25 µM 0.159311370232707 0.406420738507493 no 1378 0.436711781507984 2129 312145 A covalent inhibitor of PI 3-kinase.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.159278055553055 0.406432946767139 no 1379 0.436724904583813 2138 1241132 A phosphatase inhibitor.
SGTC_677 0929-0063 136 µM 0.158635113820705 0.406668572406102 no 1380 0.436978181128507 2133 1539583
SGTC_1682 st012968 530 nM 0.158615782052621 0.406675657646825 no 1381 0.43698579696789 1943 24207270
SGTC_2246 7293507 91.5585 µM 0.158612549113175 0.406676842546817 no 1382 0.436987070601605 2150 887656
SGTC_3174 9107204 49.47 µM 0.155868942871767 0.407682704691951 no 1383 0.438068163028559 2094 3938802
SGTC_2667 digitoxin 100 µM 0.155668499266909 0.407756215362547 no 1384 0.438147164181977 2152 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_651 3253-0966 34.4 µM 0.155632244466725 0.407769511791797 no 1385 0.438161453606774 2049 781462
SGTC_2194 5927483 104.545 µM 0.153782588519628 0.408448012797418 no 1386 0.438890581433202 2121 760979
SGTC_2671 danthron 100 µM 0.152195022385084 0.409030591602541 no 1387 0.439516559896227 2047 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_9 0092-0002 10.449 µM 0.150852326058456 0.40952346908248 no 1388 0.440046104149292 2128 759368
SGTC_741 4582-0002 126 µM 0.150517199461446 0.409646509817282 no 1389 0.440178291055253 2014 2912688
SGTC_1825 st052143 62.6 µM 0.150262678251891 0.409739962470039 no 1390 0.440278688531299 2133 674173
SGTC_1074 carmofur 3.8 µM 0.149784389253544 0.409915589898306 no 1391 0.440467362987503 2141 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_785 1270-0111 65.3 µM 0.149597766344714 0.409984122620515 no 1392 0.440540985275548 2188 6741994
SGTC_2622 2-methoxyxanthone 59.94 µM 0.149452607368515 0.410037430623722 no 1393 0.440598251563323 2117 71034 A hepatoprotective.
SGTC_2030 5175110 200 µM 0.14914447195107 0.41015059540356 no 1394 0.440719817376618 2085 2831986
SGTC_2215 7188065 200 µM 0.148883929708967 0.410246287112371 no 1395 0.440822611054696 2134 940217
SGTC_834 0312-0008 75.7 µM 0.148809193488892 0.410273737147389 no 1396 0.440852098030438 2116 6385573 YIL048W NEO1
SGTC_347 4534-1311 26.2 µM 0.14482078852864 0.411739281866365 no 1397 0.442426184192184 2129 2862016
SGTC_1786 berberine 21.6 µM 0.143426670347729 0.412251844107324 no 1398 0.442976610415065 2160 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1032 k061-1018 98.7 µM 0.143333940784288 0.412285942428181 no 1399 0.443013225849134 2175 4005393
SGTC_1613 st002381 52.1 µM 0.142866523018742 0.412457830385314 no 1400 0.443197799033927 2190 551167
SGTC_1855 st056195 39.6 µM 0.142844722477786 0.412465847714585 no 1401 0.443206407898066 2174 4028379
SGTC_3063 1327-0034 4 µM 0.141322653627813 0.413025691234436 no 1402 0.443807527102842 2132 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_669 0108-0021 26.2 µM 0.137940498037634 0.414270338955133 no 1403 0.445143721759741 2244 17201
SGTC_2774 tamoxifen 10.92 µM 0.13760540348187 0.414393702290669 no 1404 0.445276142399032 2138 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1572 epiandrosterone 68.9 µM 0.137389529722625 0.41447317957729 no 1405 0.445361453320061 2081 441302 A steroid.
SGTC_37 0566-0070 1.56 µM 0.136991485203876 0.414619735045242 no 1406 0.445518762740688 2138 1626686
SGTC_2765 myclobutanil 7.74 µM 0.1362759010537 0.41488323487448 no 1407 0.445801587156199 2065 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_817 1391-0715 46 µM 0.136143490782288 0.414931996562605 no 1408 0.445853923453143 2032 1353946
SGTC_1092 toremifene 6.32 µM 0.135023541091144 0.415344483968764 no 1409 0.446296630835456 2188 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_795 0685-0265 78 µM 0.134490890686336 0.41554069661142 no 1410 0.446507206914743 2205 302754
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.133677836048865 0.415840242468732 no 1411 0.446828666054648 2071 6708760
SGTC_1346 1488-2224 62.4 µM 0.131735762527271 0.416555939439081 no 1412 0.447596648804647 2185 3722427
SGTC_1094 duloxetine 25.4 µM 0.130558873345263 0.416989783891334 no 1413 0.448062139240471 2071 60834 A selective serotonin reuptake inhibitor.
SGTC_2820 7989630 71.43 µM 0.129471465379486 0.417390732172128 no 1414 0.448492301109063 2188 2984098
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.128628976556658 0.417701433131491 no 1415 0.448825618397149 2029 2374 Ca(2+)-ATPase inhibitor.
SGTC_234 nsc-17383 10.7 µM 0.128320409242868 0.417815242356365 no 1416 0.448947707191937 2165 408974
SGTC_1291 0993-0025 5.79 µM 0.12800105556171 0.417933037177588 no 1417 0.449074068848147 2149 4353356
SGTC_2249 haloperidol 116.36 µM 0.127299255874289 0.41819192451884 no 1418 0.449351774621291 2077 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2745 rifampicin 24.3 µM 0.126931511658697 0.418327596081819 no 1419 0.449497302828387 2198 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2645 abamectin 100 µM 0.12522705675486 0.418956545841209 no 1420 0.450171898825456 2144 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2553 4-methylesculetin 85.09 µM 0.12450682328463 0.41922237684941 no 1421 0.450456999109672 2040 5319502
SGTC_1037 k284-1091 78.7 µM 0.120767793051187 0.420603005731532 no 1422 0.451937480384039 2193 3334711
SGTC_2920 7982904 15.77 µM 0.120549690539261 0.420683569944274 no 1423 0.452023859625779 2100 6456808
SGTC_2486 5283202 22.39 µM 0.116705379855764 0.422104150361158 no 1424 0.453546763452167 2063 1377751
SGTC_3068 9116768 49.47 µM 0.114979399382916 0.422742279421118 no 1425 0.45423072532375 2109 41904888
SGTC_2766 oltipraz 83.91 µM 0.114846569550276 0.422791397657931 no 1426 0.454283368036741 2188 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2907 7721985 69.9 µM 0.114653866285736 0.422862658216024 no 1427 0.454359741032523 2083 3267881
SGTC_948 3448-0295 75.3 µM 0.113997011733514 0.423105578200711 no 1428 0.454620081146887 2186 678569
SGTC_1441 4106-0040 13 µM 0.113918121099743 0.423134755747612 no 1429 0.454651350260153 2206 2904180
SGTC_1054 3429-0080 167 µM 0.112477527931711 0.42366763029985 no 1430 0.45522239338829 2174 1162877
SGTC_3119 9125183 49.47 µM 0.109760291947893 0.424673113567736 no 1431 0.456299741573967 2206 22695334
SGTC_3272 9137413 49.47 µM 0.109360518127359 0.424821087003961 no 1432 0.456458273921449 2235 17614870
SGTC_2068 5226020 147 µM 0.10756780120328 0.425484778407802 no 1433 0.457169269833538 2141 1810509
SGTC_2675 theaflavin digallate 100 µM 0.106463606522741 0.425893673502792 no 1434 0.457607264524187 2187 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2851 9015922 71.43 µM 0.106075887008759 0.426037269111269 no 1435 0.45776107128386 2179 2996893
SGTC_233 rapamycin 362 pM 0.104094200023118 0.426771358501137 no 1436 0.458547296782848 2218 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2158 5657123 3.6195 µM 0.103655400533719 0.42693394029084 no 1437 0.458721410570336 2224 2858827
SGTC_2495 cafestol 54.53 µM 0.103287836399291 0.427070137868748 no 1438 0.458867264566079 2158 16667697 An anti-infammatory.
SGTC_2178 5812956 200 µM 0.102135445119824 0.427497202359338 no 1439 0.45932458348804 2244 5403383
SGTC_555 4296-0685 37 µM 0.101173733104683 0.427853668119003 no 1440 0.45970627382598 2237 2908540 YHR072W ERG7
SGTC_3091 9116372 49.47 µM 0.0987102893940984 0.428767029942076 no 1441 0.46068414950659 2150 17169793
SGTC_3004 9076122 71.4286 µM 0.0966024829815642 0.429548836608446 no 1442 0.461521042292798 2222 44782551
SGTC_3077 9117319 49.47 µM 0.0965695052714672 0.429561070577745 no 1443 0.461534137272413 2253 17154678
SGTC_738 1315-0003 72.4 µM 0.0957396285145122 0.429868957940299 no 1444 0.461863683220512 2227 6251474
SGTC_506 n9-isopropylolomoucine 153 µM 0.0956483371848342 0.42990282997062 no 1445 0.461899936817918 2256 6610355
SGTC_3084 9116877 49.47 µM 0.0950396544085657 0.430128684106001 no 1446 0.462141664896434 2254 27241325
SGTC_183 3914-0051 30.55 µM 0.091960265588703 0.431271652352341 no 1447 0.463364804619152 2242 1596232
SGTC_2157 5649910 96.377 µM 0.0908562062762846 0.431681583719406 no 1448 0.463803424268021 2171 2858091
SGTC_2923 7992654 58.14 µM 0.0894739698986882 0.432194904435227 no 1449 0.464352619804316 2168 2985126
SGTC_1039 k821-0043 94 µM 0.0890508196760363 0.432352072536952 no 1450 0.464520761125635 2232 15992768
SGTC_1818 st052136 56.3 µM 0.0881813698230087 0.432675040552286 no 1451 0.464866262177685 2173 674169
SGTC_450 aminopyrene 156 nM 0.0874460439914932 0.432948221641936 no 1452 0.465158485855823 2246 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1444 4112-3581 28 µM 0.0857675477553482 0.433571920076225 no 1453 0.46582560226405 2213 2877249
SGTC_3052 9092717 49.47 µM 0.0850086655446405 0.433853961201924 no 1454 0.46612725077057 2181 25237534
SGTC_1661 st013063 9.66 µM 0.0844218588165412 0.434072072994572 no 1455 0.466360514249765 2242 721395
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0836131446931666 0.434372699033898 no 1456 0.466682007790896 2096 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2390 9097792 176.6 µM 0.0827705615963138 0.434685955672097 no 1457 0.467016988613372 2098 4497149
SGTC_251 melphalan 456.522 µM 0.0809185751786046 0.435374633443084 no 1458 0.467753353775204 2196 460612 A DNA alkylator.
SGTC_1097 itavastatin 7.23 µM 0.0774250861197274 0.436674250805299 no 1459 0.469142692420594 2279 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1295 1013-0063 9.78 µM 0.076272900098046 0.437103027653927 no 1460 0.46960099280639 2285 6826038
SGTC_2050 5263056 171 µM 0.074001521838042 0.437948518925987 no 1461 0.470504587165628 2267 763468 YGL055W OLE1
SGTC_344 k064-0035 6.43 µM 0.0738689449841568 0.437997877739993 no 1462 0.470557333314541 2168 5088750
SGTC_2144 5628481 200 µM 0.072177016864991 0.438627872787867 no 1463 0.471230517672563 2239 2818399
SGTC_2922 7999257 32.47 µM 0.0719789780911394 0.438701623380774 no 1464 0.471309318751224 2288 2988377
SGTC_2883 9059145 45.46 µM 0.0715501784359934 0.438861317727151 no 1465 0.471479945119883 2264 16476510
SGTC_2003 4023581 200 µM 0.0715350296606964 0.438866959643734 no 1466 0.471485973160296 2206 16641307
SGTC_2264 7948757 110.76 µM 0.0711491162325625 0.439010691049953 no 1467 0.471639539043241 2282 2971411
SGTC_3117 9124945 49.47 µM 0.0711433954595962 0.439012821781992 no 1468 0.471641815532602 2206 17592065
SGTC_467 ro 31-8220 72.8 µM 0.069323191830097 0.439690855623918 no 1469 0.472366182865654 2283 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_705 1124-0212 310 µM 0.0687724314411472 0.439896051246957 no 1470 0.472585381319812 2292 9554485
SGTC_2263 7948595 193.29 µM 0.0686580876561586 0.439938654092811 no 1471 0.472630890321288 2283 2971371
SGTC_2183 6420625 130.508 µM 0.0685070671967288 0.439994923204576 no 1472 0.472690997242796 2276 2897619
SGTC_132 0417-1715 25.805 µM 0.0676462517574938 0.440315679812406 no 1473 0.473033618059651 2307 6769098
SGTC_2082 5219693 150 µM 0.0664732421512684 0.440752829067805 no 1474 0.473500530124962 2292 2834649
SGTC_763 3453-1109 128 µM 0.0657991185161334 0.441004089595459 no 1475 0.473768879019672 2295 1560353
SGTC_2677 mitomycin C 100 µM 0.0657094661191528 0.441037506783459 no 1476 0.473804567915165 2286 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_758 0868-0029 16 µM 0.0656936430359769 0.441043404750177 no 1477 0.473810866802183 2304 762687
SGTC_2402 5553605 200 µM 0.0632957595131233 0.441937352962192 no 1478 0.4747654962064 2252 6758546
SGTC_1096 rimcazole 32.2 µM 0.0623241643571101 0.442299655086587 no 1479 0.475152342752813 2257 18528119 A dopamine reuptake inhibitor.
SGTC_3323 9138564 53.9225 µM 0.0607696727458683 0.442879416139746 no 1480 0.475771321654721 2307 43912313 YNL103W MET4
SGTC_672 1441-0018 53.7 µM 0.0604192666023947 0.443010120072296 no 1481 0.475910857079274 2275 251141
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0600487592258956 0.443148328650235 no 1482 0.476058400239851 2238 279621
SGTC_2448 5185112 27.17 µM 0.0566638346424452 0.444411308913985 no 1483 0.47740649174023 2229 5718189
SGTC_3270 9137563 49.47 µM 0.054856363516298 0.445085943124088 no 1484 0.478126448184569 2282 17015724
SGTC_1914 st062367 72.6 µM 0.0541161574511285 0.445362269264726 no 1485 0.47842130966306 2272 978205
SGTC_1478 0453-0656 35.7 µM 0.0523673959634094 0.446015204185576 no 1486 0.479117976354187 2307 5258496
SGTC_1016 4226-1401 38 µM 0.0513804252890858 0.446383774091434 no 1487 0.479511191262177 2315 2901613
SGTC_3081 9117243 49.47 µM 0.0508528727095924 0.446580799981814 no 1488 0.479721379507707 2291 45595589
SGTC_1225 1216-0074 20.6 µM 0.0507829659499007 0.446606909159741 no 1489 0.479749232282249 2256 4241466
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0494446879764639 0.447106781397703 no 1490 0.480282457918204 2220 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1857 st056007 79.3 µM 0.0487820264968508 0.447354329203088 no 1491 0.48054650294868 2317 619834
SGTC_2792 7535235 81.82 µM 0.047202168128264 0.447944593152398 no 1492 0.481176049766788 2266 1281891
SGTC_29 0299-0004 12.984 µM 0.0471697779894476 0.447956695910447 no 1493 0.48118895718534 2313 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3140 9094243 49.47 µM 0.0457609353086727 0.448483164653713 no 1494 0.481750397640283 2340 19291112
SGTC_546 peri-Naphthalide 147 µM 0.0443839833061502 0.44899780389717 no 1495 0.482299164268668 2291 223824 A penicillin ester.
SGTC_1461 k072-0203 53.8 µM 0.0443488637986693 0.449010931026661 no 1496 0.482313161142707 2311 5418714
SGTC_1683 st010134 710 nM 0.0436259518900609 0.449281156711749 no 1497 0.482601282385161 2328 3818134
SGTC_2591 skatole 100 µM 0.0426979934508454 0.449628063598425 no 1498 0.482971139553464 2285 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1193 1488-0126 41.5 µM 0.0417683289028253 0.449975646902763 no 1499 0.483341691421976 2340 1384710
SGTC_1067 clotrimazole 1.36 µM 0.0414751714543162 0.450085260683459 no 1500 0.483458543063591 2292 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3302 9125395 16.351 µM 0.0414374567801741 0.450099362761172 no 1501 0.483473576118046 2260 17599668
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.041422994212482 0.450104770547095 no 1502 0.48347934089814 2333 165521
SGTC_636 0kpi-0074 126 µM 0.0395357314983139 0.450810527450169 no 1503 0.484231633079925 2289 616434
SGTC_885 0865-0106 16.8 µM 0.0392695778525888 0.450910070289305 no 1504 0.484337730628106 2318 2793380
SGTC_2139 5578692 56.4705 µM 0.039154133535521 0.450953248020986 no 1505 0.484383750853937 2343 650991 YMR113W FOL3
SGTC_1767 st044992 70.3 µM 0.037928619409054 0.451411642516465 no 1506 0.484872297236275 2308 9600693
SGTC_1968 st069590 43.6 µM 0.0369885666215622 0.451763306257317 no 1507 0.485247061008793 2322 6384066
SGTC_3155 9099265 49.47 µM 0.0369433165603081 0.451780234780647 no 1508 0.485265100841662 2305 25236499
SGTC_2196 6573537 42.6665 µM 0.0333038955167278 0.453142064903016 no 1509 0.486716123655725 2347 2903087
SGTC_2595 hexamethylquercetagetin 100 µM 0.0332455514463897 0.453163901125466 no 1510 0.486739386690125 2310 386331
SGTC_3307 9126885 69.2785 µM 0.0331896609801192 0.453184819179283 no 1511 0.486761671462183 2332 24824909
SGTC_1813 st051246 8.6015 µM 0.0317773187823854 0.453713457661898 no 1512 0.487324817244814 2352 5291959
SGTC_2225 6654152 15.4 µM 0.031730179648651 0.453731103219199 no 1513 0.487343613559764 2343 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2521 angolensin 13.4 µM 0.0315727896151944 0.453790019576197 no 1514 0.487406371654637 2302 821428 A flavenoid.
SGTC_1161 k007-0610 110 µM 0.0314349812085853 0.453841606709989 no 1515 0.487461321978862 2348 5843850
SGTC_1775 st081588 35.1725 µM 0.0300263403442453 0.454368961178187 no 1516 0.4880230230407 2341 1426443 YGL099W LSG1
SGTC_2748 diazoxide 86.69 µM 0.0298094508392034 0.454450165516669 no 1517 0.488109510718888 2337 3019 A potassium channel activatior.
SGTC_1770 st043884 66.3 µM 0.0286221438950281 0.454894731854351 no 1518 0.488582975521835 2359 670149
SGTC_624 k048-0052 28 µM 0.0280045149999716 0.455126014576377 no 1519 0.488829275055621 2309 6835531
SGTC_2520 obtusaquinone 4.71 µM 0.0270611226904261 0.455479314853398 no 1520 0.489205491497344 2348 5967872
SGTC_361 000s-0510 1.45 µM 0.0270405818319287 0.45548700779449 no 1521 0.489213683116623 2318 660
SGTC_1512 0259-0544 12.2 µM 0.0269241277905016 0.455530622357174 no 1522 0.489260124648548 2287 18476
SGTC_1389 3405-0187 19 µM 0.0267648220411228 0.455590286681251 no 1523 0.48932365555229 2340 799890
SGTC_2571 chrysanthemic acid 100 µM 0.0255053012122736 0.45606204655069 no 1524 0.48982596005408 2304 2743 An insecticide.
SGTC_1951 sophoraflavanone G 9.2 µM 0.0254491645825777 0.456083074255031 no 1525 0.489848348062053 2362 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2303 7774051 200 µM 0.02536983709388 0.45611278901988 no 1526 0.489879984936577 2346 2953184
SGTC_1946 st076057 65.1 µM 0.0251900205232749 0.456180146240852 no 1527 0.4899516984504 2368 953009
SGTC_876 0720-0963 56.8 µM 0.0242966798517615 0.456514800022011 no 1528 0.490307980722581 2357 765861
SGTC_2189 6047310 154.431 µM 0.0236691921941759 0.456749881231371 no 1529 0.490558240092922 2343 711535
SGTC_2605 digitonin 300 nM 0.0232072240508159 0.45692296209123 no 1530 0.490742488100633 2359 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_332 4112-0506 40.9 µM 0.0231054018927765 0.45696111185371 no 1531 0.490783098375164 2353 2790355
SGTC_109 0132-0036 33.701 µM 0.0227366181401356 0.457099287577158 no 1532 0.490930183163343 2348 67274 A color developer.
SGTC_1521 st012942 49.4 µM 0.0223032445728983 0.457261670409575 no 1533 0.491103030366116 2357 24207259
SGTC_339 3091-4833 71.4 µM 0.0217029503962474 0.457486609312126 no 1534 0.491342455126143 2357 3240077
SGTC_1922 5578187 25 µM 0.0216181552060735 0.457518384394663 no 1535 0.491376275577805 2370 1350412
SGTC_2773 thioridazine 9.09 µM 0.0204033081861215 0.457973650595834 no 1536 0.491860822424881 2375 5452 An antipsychotic.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0203161998062915 0.458006296750551 no 1537 0.491895566438778 2359 23847180
SGTC_2481 5478948 45.16 µM 0.0203031392817194 0.458011191549818 no 1538 0.491900775759746 2355 77792
SGTC_3066 9117245 49.47 µM 0.0159105217999577 0.459657805172873 no 1539 0.493652887941512 2366 17176980
SGTC_939 1165-0479 45.3 µM 0.015504246375425 0.459810136708425 no 1540 0.493814948391566 2385 1377347
SGTC_1258 0671-0043 57.1 µM 0.0150273346459542 0.459988960603065 no 1541 0.494005186474421 2357 4298767
SGTC_992 3909-8734 162 µM 0.0145160423387274 0.460180684905548 no 1542 0.494209140338332 2373 4288319
SGTC_1929 genistein trimethyl ether 50.5 µM 0.0141601909540087 0.460314127464262 no 1543 0.494351089908628 2393 136420
SGTC_2955 9076254 12.21 µM 0.0135042676488859 0.460560107252557 no 1544 0.494612740410985 2377 16459619
SGTC_2407 paclitaxel 400 µM 0.0129232971727087 0.460777991360712 no 1545 0.49484449386091 2321 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1189 1431-2119 7.28 µM 0.0107406706160404 0.461596656819878 no 1546 0.495715174755893 2381 3107275
SGTC_1707 st032323 6.317 µM 0.009681578458322 0.461993962826648 no 1547 0.496137669349994 2392 3132057 YMR211W DML1
SGTC_1304 1165-0502 251 µM 0.00948722018301285 0.462066878185546 no 1548 0.496215203522185 2390 767425
SGTC_889 0919-1524 82.7 µM 0.00900087624906308 0.462249340327505 no 1549 0.496409218388645 2363 3905452
SGTC_560 2332-1943 155 µM 0.00896415540559422 0.462263117246259 no 1550 0.496423867294686 2388 21177716
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0081817519149444 0.462556669965018 no 1551 0.496735989649468 2387 94937 An inhibitor of serotonin biosynthesis.
SGTC_2223 6903751 107.57 µM 0.00764326787014082 0.462758717546638 no 1552 0.49695080697494 2385 5598863
SGTC_1906 st060206 94.7 µM 0.00762345779684461 0.46276615077755 no 1553 0.49695870982051 2387 5133468
SGTC_1974 st069448 26.9 µM 0.00725658475239805 0.462903812991824 no 1554 0.497105066937883 2387 6323587 YNR016C ACC1
SGTC_2918 7977171 22.06 µM 0.00413637546167165 0.464074790799299 no 1555 0.498349829646352 2396 2236483
SGTC_1202 1988-0068 29.6 µM 0.00372388563671281 0.464229616887487 no 1556 0.498514388005714 2388 2850480
SGTC_2445 5742597 35.57 µM 0.00350765215665878 0.464310781258297 no 1557 0.498600652119276 2395 1774255
SGTC_1556 plumbagin 1.48 µM 0.00298354196508428 0.464507514923398 no 1558 0.49880974073063 2396 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_507 nimesulide 162 µM 0.0028633622396947 0.464552627649926 no 1559 0.498857685299424 2395 4495 A COX2 inhibitor.
SGTC_1425 4048-4433 7.33 µM 0.00106165455462053 0.46522900190245 no 1560 0.499576461190544 2401 23734946
SGTC_955 1216-0110 33 µM -0.00209377090132806 0.466413812605128 no 1561 0.49916470687229 2407 3619719
SGTC_2740 felodipine 17.08 µM -0.00327448352285933 0.466857228006845 no 1562 0.498693672410714 2414 3333 L-type calcium channel blocker
SGTC_2698 st077697 67.5 µM -0.00347590013752022 0.466932873930245 no 1563 0.498613319264976 2415 3154499
SGTC_376 3970-0862 59.1 µM -0.00390975737197205 0.467095821498729 no 1564 0.49844023645202 2414 3135186
SGTC_2333 9017922 200 µM -0.00451252800003421 0.467322218499815 no 1565 0.498199767898953 2416 3163164
SGTC_2204 7233102 200 µM -0.00461067493369255 0.467359082897033 no 1566 0.498160613344811 2417 2172480
SGTC_1568 digitonin 820 nM -0.00486952417595991 0.467456309092972 no 1567 0.49805734859822 2415 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1608 st001473 40.5 µM -0.0052840247061852 0.467612003409626 no 1568 0.497891988943622 2417 7292267
SGTC_133 0724-0033 378.92 µM -0.0072330765695182 0.468344170553459 no 1569 0.497114445099847 2414 280309
SGTC_793 0488-0545 106 µM -0.0074231042671617 0.468415560793803 no 1570 0.497038637052431 2422 292548
SGTC_1147 3809-1045 12.3 µM -0.00788336504105719 0.468588477303824 no 1571 0.496855024948678 2413 325925
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.00806133497565996 0.468655340859793 no 1572 0.496784027473496 2419 688803
SGTC_721 1187-1332 279 µM -0.00843023738838408 0.468793940831255 no 1573 0.496636861707758 2422 25730
SGTC_3286 9117135 37.221 µM -0.00892979779924081 0.468981636219284 no 1574 0.496437573447924 2423 3438150
SGTC_831 k061-1017 217 µM -0.00902455089181018 0.469017237734717 no 1575 0.496399773956268 2436 1240153
SGTC_1882 5615643 20 µM -0.00948595436205638 0.469190604083917 no 1576 0.496215708488961 2418 2253075
SGTC_160 3453-0671 289.699 µM -0.00959833169283193 0.469232829289366 no 1577 0.496170878461369 2425 5322268
SGTC_1060 3448-7350 82 µM -0.0104994864774945 0.4695714460498 no 1578 0.495811387879985 2424 570178
SGTC_2354 9060492 162 µM -0.0109236958388467 0.469730854046274 no 1579 0.495642162539851 2416 6471895
SGTC_2187 6125751 200 µM -0.0115398693458336 0.469962406331728 no 1580 0.495396360384561 2433 874498
SGTC_403 arphamenine a 50 µM -0.0116744354359155 0.470012976373664 no 1581 0.495342679897959 2432 5487158 An arginine aminopeptidase inhibitor.
SGTC_2953 9074162 66.49 µM -0.0117573160033529 0.470044123196488 no 1582 0.495309617604566 2424 16451992
SGTC_932 2857-0803 154 µM -0.0128215965756485 0.470444099981138 no 1583 0.494885063167698 2462 674898
SGTC_2958 9077254 16.72 µM -0.0128517320469793 0.470455425897735 no 1584 0.494873041844522 2445 16457351
SGTC_954 1189-0853 2.85 µM -0.0136256885005266 0.470746312745045 no 1585 0.494564304956049 2424 2828194
SGTC_1373 2887-0003 58.5 µM -0.0138801113833416 0.470841939461844 no 1586 0.494462814509786 2454 776948
SGTC_3049 9092223 49.47 µM -0.0174171902516718 0.472171548358807 no 1587 0.493051897698923 2459 8623917
SGTC_481 bay k-8644 50 µM -0.021367357661219 0.473656805651729 no 1588 0.491476306215332 2440 2303 A calcium channel antagonist.
SGTC_3007 9078383 71.4286 µM -0.0216828867794914 0.473775460218697 no 1589 0.491350457468061 2462 6496995
SGTC_497 capsazepine 133 µM -0.0217616659475432 0.473805085448772 no 1590 0.491319036541089 2451 2733484 A calcium channel blocker.
SGTC_771 0250-0039 27.3 µM -0.0242301216949018 0.474733430931785 no 1591 0.4903345257706 2444 3005115
SGTC_2724 maprotiline 69.64 µM -0.0243360463122421 0.474773270538923 no 1592 0.490292280419434 2435 4011 A tricyclic antidepressant.
SGTC_2710 st078562 53.7235 µM -0.0243895251044837 0.47479338469444 no 1593 0.490270951798797 2441 17250908
SGTC_2409 alverine citrate 63.97 µM -0.0244341057725468 0.474810152184485 no 1594 0.490253171984031 2651 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_639 0833-0042 114 µM -0.0247169575103783 0.474916538207717 no 1595 0.490140364537655 2468 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1151 3909-8316 15.3 µM -0.0255748901230122 0.475239234207236 no 1596 0.489798207148382 2516 800431
SGTC_1501 4491-0275 38.4 µM -0.0260699324306376 0.475425442916357 no 1597 0.489600779676288 2446 5104718
SGTC_1982 st072467 71.9 µM -0.0263071354533195 0.475514668040844 no 1598 0.489506181806754 2447 3163533
SGTC_1056 3448-1962 115 µM -0.0267233583156738 0.475671235354258 no 1599 0.489340191270859 2479 715507
SGTC_1976 st070609 63.5 µM -0.0267712540140522 0.475689252147666 no 1600 0.489321090485478 2449 682556
SGTC_1839 st053978 48 µM -0.0268557336946814 0.475721030758406 no 1601 0.489287400082311 2449 3788398
SGTC_2213 7173844 200 µM -0.0275475824630462 0.475981288396013 no 1602 0.489011494456804 2448 892728
SGTC_1239 0337-0584 35.4 µM -0.0280250264276486 0.476160897846779 no 1603 0.488821095390332 2470 914301 YML130C ERO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0289131260486755 0.476495004538559 no 1604 0.488466938463038 2467 5024745
SGTC_2873 9040596 71.43 µM -0.0306662882130168 0.477154599564893 no 1605 0.487767838309657 2541 6463863
SGTC_157 1348-1695 65.819 µM -0.0308083466157074 0.477208049192294 no 1606 0.487711191972146 2468 5380510
SGTC_2493 resveratrol 26.09 µM -0.0311384021711416 0.477332234532731 no 1607 0.487579582001949 2447 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2426 5582046 32.21 µM -0.0325979054251174 0.477881407424791 no 1608 0.48699762008644 2485 2251934
SGTC_1005 4092-0690 4.4 µM -0.0334025739918787 0.478184201184373 no 1609 0.486676778530437 2483 1529343
SGTC_2489 cantharidin 73.42 µM -0.034517979035474 0.478603944702501 no 1610 0.48623205284692 2474 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2472 5377652 49.4 µM -0.0345761276906423 0.478625827561735 no 1611 0.486208868729066 2487 1610903
SGTC_974 1326-0144 138 µM -0.0348459510936355 0.478727370004932 no 1612 0.486101289593919 2474 5411856
SGTC_2882 9058044 58.44 µM -0.0349812098011126 0.47877827233502 no 1613 0.486047362054478 2504 18076804
SGTC_3054 9094397 49.47 µM -0.0355797985664187 0.479003545251122 no 1614 0.485808708265067 2478 2598354
SGTC_1088 bifonazole 369 nM -0.0357341682929108 0.479061641850014 no 1615 0.485747162791942 2450 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_922 1866-0035 480 µM -0.0363779343421043 0.479303926117633 no 1616 0.485490504187972 2482 3156169
SGTC_1607 st000305 50.6 µM -0.0374897622606187 0.479722385547078 no 1617 0.485047251471228 2459 5457690
SGTC_1785 bathophenanthroline 24 µM -0.0383483550416188 0.480045550013439 no 1618 0.484704968684731 2482 72812 An iron chelator.
SGTC_2014 4013930 200 µM -0.0392659994794684 0.480390955340578 no 1619 0.48433915709224 2469 64556
SGTC_1323 1348-1351 11.2 µM -0.0398544106768838 0.480612443618679 no 1620 0.484104598605709 2490 6989654
SGTC_1751 st044839 27.194 µM -0.0402425200876203 0.480758538077125 no 1621 0.483949889470487 2474 5291326
SGTC_1739 st037196 92.5 µM -0.0418739283775186 0.481372670548229 no 1622 0.483299600151811 2482 612214
SGTC_1628 st004252 77.7 µM -0.0419937928144058 0.481417794455259 no 1623 0.483251823185192 2510 692968
SGTC_1965 Pectolinarigenin 58.4 µM -0.0422979955935534 0.481532315043988 no 1624 0.483130571571267 2484 5320438 An anti-inflammatory.
SGTC_605 1315-0399 119 µM -0.0433923721476523 0.481944318054003 no 1625 0.482694379060127 2541 24020461
SGTC_1643 st009866 20.2 µM -0.0474488856863003 0.483471649842475 no 1626 0.481077733862825 2492 3156273 YOR207C RET1
SGTC_3127 9126946 49.47 µM -0.047544419231844 0.483507622515987 no 1627 0.481039664457547 2552 27243249
SGTC_1646 st011709 75.6 µM -0.0482702420903157 0.483780931806794 no 1628 0.480750435134968 2487 5757843
SGTC_1259 0671-0132 43 µM -0.0507920697914501 0.484730586852293 no 1629 0.479745605055941 2522 X1259
SGTC_3141 9094609 49.47 µM -0.0516105344092235 0.485038818322857 no 1630 0.47941951264184 2502 25236309 YDL196W YDL196W
SGTC_322 k048-0136 19.3 µM -0.0528291236931042 0.485497752123928 no 1631 0.478934028271743 2569 6823282
SGTC_2752 diclazuril 33.15 µM -0.0554895694189501 0.486499770450995 no 1632 0.477874219773043 2538 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2381 9035592 200 µM -0.0555018667328323 0.486504402258835 no 1633 0.477869321403349 2536 4749657
SGTC_1105 epirubicin 18.1 µM -0.0567014382208977 0.486956231910223 no 1634 0.477391514163117 2502 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2988 9073640 71.4286 µM -0.0570863820377003 0.487101228121421 no 1635 0.477238192146197 2575 9102229
SGTC_2468 5987765 72.9 µM -0.0577318442855877 0.48734435723687 no 1636 0.476981113958769 2572 26772094
SGTC_1185 1319-0113 81.3 µM -0.0591470091114054 0.48787742995756 no 1637 0.476417508148991 2566 4672763
SGTC_1719 st032227 49.2 µM -0.059410102364843 0.487976535908297 no 1638 0.47631273337513 2537 3125804
SGTC_3223 9129970 49.47 µM -0.0601806839751385 0.488266814507558 no 1639 0.476005864890986 2528 17248386
SGTC_145 3737-0113 38.366 µM -0.0601889164378705 0.488269915715513 no 1640 0.476002586556319 2576 6849351
SGTC_1802 st050112 57.9 µM -0.0614983296782299 0.488763186827078 no 1641 0.475481172306983 2482 4662563
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0616074494576435 0.488804294296289 no 1642 0.475437722202352 2514 16486 A toxic proline analog.
SGTC_327 1273-0057 3.96 µM -0.0622834652849766 0.489058964781947 no 1643 0.475168547850723 2518 3108138
SGTC_3138 9097216 49.47 µM -0.0625495411938949 0.489159202837252 no 1644 0.475062605488473 2502 25237486
SGTC_1728 st035614 33.7865 µM -0.0627747115264278 0.48924403118092 no 1645 0.474972951710284 2646 15945546
SGTC_1336 1486-0901 104 µM -0.0643493633614611 0.4898372626215 no 1646 0.474346024295963 2605 5006114
SGTC_424 splitomicin 100 mM -0.0662465533650418 0.490552036242141 no 1647 0.4735907669621 2617 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_308 4092-1169 104 µM -0.0670058027710273 0.490838095001514 no 1648 0.473288541820795 2524 2268590 YDL196W YDL196W
SGTC_3104 9120930 49.47 µM -0.0671711927507331 0.490900408821544 no 1649 0.473222709084219 2586 17014836
SGTC_213 1246-0773 967 nM -0.0674448061432207 0.491003498357284 no 1650 0.473113800112226 2564 6251622
SGTC_1715 st032160 10.2275 µM -0.0677361376878501 0.491113264235724 no 1651 0.472997840822997 2558 5289825
SGTC_448 monastrol 171 µM -0.0677592360394971 0.491121967101329 no 1652 0.472988647036732 2546 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_389 tpck 16.7 µM -0.0685878793808842 0.491434181391733 no 1653 0.472658833499401 2562 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1570 verbenone 133 µM -0.0698942299401481 0.491926395668441 no 1654 0.472138922870075 2562 29025 A natural terpanoid with antifungal properties.
SGTC_674 0498-0004 451 µM -0.0716788213416124 0.492598824000833 no 1655 0.471428755460821 2555 4231473
SGTC_3129 9127257 49.47 µM -0.0726158636498803 0.4929519070878 no 1656 0.471055901340427 2555 837894
SGTC_2131 toluylene red 5.2905 µM -0.0727511909374111 0.493002899673433 no 1657 0.471002055981484 2548 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2878 9043973 25.97 µM -0.0732614194667006 0.493195159569135 no 1658 0.47079904598579 2695 6465167
SGTC_1194 1488-0194 225 µM -0.0732869584421161 0.493204782986591 no 1659 0.470788884723797 2528 1391452
SGTC_1632 st005650 90 µM -0.0744935356076192 0.493659441333723 no 1660 0.470308842357402 2617 2759605
SGTC_1820 st053765 18.6 µM -0.0745857738769125 0.493694198594342 no 1661 0.47027214669714 2598 3690829
SGTC_90 0870-0863 4.608 µM -0.0751076674880644 0.493890859642511 no 1662 0.470064523642819 2541 1738164
SGTC_2777 climbazole 1.536 µM -0.0769665218076415 0.494591328767478 no 1663 0.469325088833278 2545 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2010 4012422 159 µM -0.0774295190077318 0.494765801946332 no 1664 0.469140929247175 2599 952393
SGTC_691 1548-0686 185 µM -0.0774932748731803 0.494789827415976 no 1665 0.469115570530615 2562 46495133
SGTC_991 3996-0057 64.7 µM -0.0786394599886002 0.495221753728621 no 1666 0.468659700089156 2606 715343
SGTC_489 paxilline 115 µM -0.080326536753197 0.495857518711472 no 1667 0.467988776562969 2598 105008 A toxic potassium channel blocker.
SGTC_531 3788-1495 174 µM -0.0804672585522464 0.495910549393705 no 1668 0.467932817829299 2531 2896655
SGTC_84 0443-0269 128.823 µM -0.0812732379151527 0.496214282203301 no 1669 0.467612328308559 2537 6150058
SGTC_961 1252-1571 372 µM -0.0837748808129996 0.497157037926415 no 1670 0.466617710002275 2604 6813498
SGTC_1843 st055809 45.5 µM -0.0850767353028156 0.497647654440099 no 1671 0.466100192887979 2672 16413835
SGTC_2104 5389443 200 µM -0.0854022952704937 0.497770345462246 no 1672 0.465970784234707 2668 2244536
SGTC_3309 9129340 25.759 µM -0.0877356187365983 0.498649690749068 no 1673 0.465043404555601 2625 17158987
SGTC_3251 9135047 49.47 µM -0.0883131870409787 0.49886735654777 no 1674 0.464813879082639 2668 17682963
SGTC_2541 muurolladie-3-one 83.07 µM -0.0892491130870141 0.499220075846644 no 1675 0.464441967238901 2725 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_820 1582-0060 59.9 µM -0.0901264965504163 0.49955073295832 no 1676 0.464093346847991 2598 3848840
SGTC_3158 9100007 49.47 µM -0.090258693416797 0.499600553662947 no 1677 0.464040822000798 2588 19297233
SGTC_2545 solidagenone 89.61 µM -0.0905343038956081 0.499704422318549 no 1678 0.463931317652342 2544 6708572 An anti ulcer agent
SGTC_1687 st020778 55.3625 µM -0.0921029057448204 0.499704422318549 no 1679 0.463308139908629 2588 4259299
SGTC_3354 9151612 71.43 µM -0.0928870028191014 0.499408921623877 no 1680 0.462996665675837 2637 27261949
SGTC_3190 9110366 49.47 µM -0.0941785010955408 0.498922198696001 no 1681 0.462483681248802 2584 17123768
SGTC_3225 9130819 49.47 µM -0.0942996701036244 0.498876534180883 no 1682 0.462435555983969 2582 4547121
SGTC_301 4119-0100 24.5 µM -0.0944022164551513 0.498837887928816 no 1683 0.462394827596811 2586 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2625 euphol 100 µM -0.0946893484924085 0.498729677633131 no 1684 0.462280789316869 2634 6708538 A triterpene alcohol.
SGTC_1378 2093-0007 380 nM -0.0947139498580518 0.498720406219672 no 1685 0.462271018703735 2646 3618014
SGTC_2412 st077135 33.4 µM -0.0950724026213628 0.498585317711556 no 1686 0.462128659140391 2862 13258915
SGTC_2024 5144227 134 µM -0.0950981394765233 0.498575618382797 no 1687 0.462118437931343 2662 3475211
SGTC_3128 9127691 49.47 µM -0.0956156248099871 0.498380596281279 no 1688 0.461912927627742 2734 41316314
SGTC_415 dibenzyl ketone 100 µM -0.0965173629009954 0.49804076372302 no 1689 0.461554842351163 2678 7593
SGTC_218 alverine citrate 93.75 µM -0.0967174652400852 0.497965352553748 no 1690 0.461475384799802 2676 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1479 0549-0158 134 µM -0.0967521375593104 0.49795228584657 no 1691 0.461461617113039 2618 5440202
SGTC_2020 4017018 200 µM -0.0967799157580095 0.497941817278516 no 1692 0.461450586977422 2658 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3112 9123419 49.47 µM -0.0975491152033929 0.497651935256934 no 1693 0.461145165943574 2570 17015854
SGTC_1173 0443-0020 122 µM -0.0976924295242509 0.497597925671462 no 1694 0.461088263583128 2601 5331295
SGTC_1513 0337-0559 19 µM -0.0980078329316229 0.497479062568575 no 1695 0.460963036767707 2598 775073
SGTC_1206 3978-0017 132 µM -0.0986896767466497 0.4972221033094 no 1696 0.460692332806364 2843 3873677
SGTC_1351 1496-0003 46.5 µM -0.0994677572480933 0.496928877763266 no 1697 0.460383443451823 2647 3891978
SGTC_1269 0831-0796 3.05 µM -0.101612007405687 0.496120809873175 no 1698 0.459532324126467 2643 927758
SGTC_879 0831-1030 162 µM -0.10223847657317 0.495884725715197 no 1699 0.45928369393135 2603 1549252
SGTC_1703 st026983 48.3 µM -0.102326518756842 0.495851547236982 no 1700 0.459248753429376 2601 1104023
SGTC_2444 5485484 36.41 µM -0.102392600200864 0.495826644627791 no 1701 0.459222528493517 2672 6790631
SGTC_517 1365-0151 113 µM -0.104070731710778 0.495194251130031 no 1702 0.458556608709247 2740 768657
SGTC_2801 7907800 81.82 µM -0.104074233136967 0.495192931651264 no 1703 0.458555219386641 2662 6620925
SGTC_2517 totarol 10 µM -0.104221477472419 0.495137444088099 no 1704 0.458496795114001 2639 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_49 0717-0965 32.132 µM -0.104366342254644 0.4950828533277 no 1705 0.45843931588619 2873 5889349 YGL099W LSG1
SGTC_1961 st076550 68.7 µM -0.104813148220067 0.494914479811645 no 1706 0.458262038374094 2695 1579337
SGTC_2217 6934799 96.0675 µM -0.106283466393254 0.494360414446057 no 1707 0.457678724595176 2608 675606
SGTC_1489 4065-0444 182 µM -0.10670014258014 0.494203398769178 no 1708 0.457513434745524 2591 2877968
SGTC_2570 licareol 100 µM -0.106925765307338 0.494118377952476 no 1709 0.457423936303569 2711 443158
SGTC_1527 coumarin 137 µM -0.107521099777929 0.493894040928133 no 1710 0.457187793575303 2821 323 A hepatotoxic, DNA x-linker.
SGTC_2013 4024628 200 µM -0.107696330661624 0.493828009881952 no 1711 0.457118290146441 2708 5230760
SGTC_2411 st077133 39.94 µM -0.110943915204254 0.492604277505134 no 1712 0.455830410616923 2904 1403142 YNL221C POP1
SGTC_2581 avocatin a 64 µM -0.111210331709561 0.492503891210362 no 1713 0.455724779468511 2664 6710728 A skin care supplement.
SGTC_2370 9071495 200 µM -0.111899689784213 0.492244141869387 no 1714 0.455451471287953 2664 21791103
SGTC_964 1287-0107 19.4 µM -0.112130582385571 0.492157142528733 no 1715 0.455359934546056 2703 51516812 YPR165W RHO1
SGTC_2994 9053520 71.4286 µM -0.112147601666966 0.492150729751304 no 1716 0.4553531873921 2694 4647384
SGTC_2181 6316240 54.2555 µM -0.112177252172338 0.492139557598689 no 1717 0.455341432724178 2679 12779990
SGTC_2025 5147754 141 µM -0.113240565702912 0.491738910862496 no 1718 0.454919917854484 2681 315777 YLR208W SEC13
SGTC_511 blebbistatin 171 µM -0.114298275695083 0.49134038375549 no 1719 0.454500674669379 2754 3476986 A myosin inhibitor.
SGTC_67 0335-0847 266 µM -0.114651948196002 0.491207127890686 no 1720 0.454360501226673 2987 4552207 YOR254C SEC63
SGTC_1884 5633444 25 µM -0.114883953073075 0.491119714189406 no 1721 0.454268552232086 2729 5724239
SGTC_1006 4099-6547 255 µM -0.115622121503165 0.49084159343391 no 1722 0.453976015032485 2698 3146833
SGTC_2121 5257820 149.641 µM -0.116141495238984 0.490645910923011 no 1723 0.453770201435424 2668 791256
SGTC_3236 9132701 49.47 µM -0.117003514377792 0.490321136169943 no 1724 0.453428634270791 2640 24282524
SGTC_2233 sulbentine 40.3845 µM -0.117036508646009 0.490308705359421 no 1725 0.453415561278025 2606 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1563 conessine 56.1 µM -0.117085360174347 0.490290300237719 no 1726 0.453396205412531 2704 441082 An anti-amoebic, histamine inhibitor.
SGTC_1859 st055998 20 µM -0.117790705649859 0.490024559200783 no 1727 0.4531167470474 2614 676301
SGTC_2635 hydroquinidine 100 µM -0.118087248089581 0.489912837256857 no 1728 0.452999263652229 2631 442912 An experimental heart treatment.
SGTC_2627 acetyl isogambogic acid 100 µM -0.118292514470156 0.489835503901849 no 1729 0.452917944172241 2710 6857789 A caspase activator and apoptosis inducer.
SGTC_2891 9063876 19.48 µM -0.119316125045295 0.489449868138464 no 1730 0.45251245440995 2653 6472478
SGTC_430 0958-0115 16.4 µM -0.119740873227624 0.489289851086096 no 1731 0.452344210560896 2648 6833180
SGTC_1916 st067606 49.2 µM -0.119947621265744 0.489211962707177 no 1732 0.452262320224764 2732 19590279
SGTC_3280 9140961 49.47 µM -0.120341959552303 0.489063404424286 no 1733 0.452106133349087 2604 4901226
SGTC_3150 9097574 49.47 µM -0.121198598387436 0.488740689825818 no 1734 0.451766867129723 2665 17217476
SGTC_2108 5365811 200 µM -0.122148220819605 0.48838295489515 no 1735 0.451390816538205 2707 780283
SGTC_3015 9080845 49.47 µM -0.122190579647388 0.488366997997906 no 1736 0.45137404345128 2723 5296973
SGTC_3074 9116018 49.47 µM -0.12614770796981 0.486876402821869 no 1737 0.449807501788167 2606 17027303
SGTC_3113 9123498 49.47 µM -0.127522501467481 0.486358579090659 no 1738 0.44926343248584 2614 8897275
SGTC_2909 7941780 10.49 µM -0.127597483480963 0.486330337345541 no 1739 0.449233761372572 2642 1243215
SGTC_1198 1612-1005 86.7 µM -0.127613360617661 0.486324357279551 no 1740 0.449227478671307 2809 6998509
SGTC_1273 0849-0096 14.1 µM -0.128529497490087 0.485979302898334 no 1741 0.448864978094862 2670 5286025
SGTC_3316 9136639 10.545 µM -0.129228240861309 0.485716134787881 no 1742 0.448588525294314 2727 4903665
SGTC_1837 st055472 66.5 µM -0.129409222395977 0.485647972619981 no 1743 0.448516925313505 2781 676091
SGTC_299 1273-0059 1.44 µM -0.131435201661678 0.484884967290453 no 1744 0.447715521647546 2699 2848077
SGTC_2572 astragaloside iv 100 µM -0.133344816954996 0.484165836483358 no 1745 0.446960342619881 2832 45006101 An anti-inflammatory agent.
SGTC_3209 9113616 49.47 µM -0.13436088664541 0.48378322160964 no 1746 0.446558604533328 2705 16649353
SGTC_1861 st057647 17.4 µM -0.134766456348036 0.483630502967129 no 1747 0.446398263898312 2845 688668
SGTC_2987 9018338 71.43 µM -0.135455097473316 0.483371198336089 no 1748 0.446126032003229 2612 5055682
SGTC_1372 2752-0194 270 µM -0.136669467427541 0.482913950150496 no 1749 0.445646032245476 2638 823334
SGTC_1653 st012112 65 µM -0.136694990654629 0.482904340097985 no 1750 0.445635944621187 2777 720429
SGTC_3125 9127534 49.47 µM -0.136732788899979 0.482890108251218 no 1751 0.445621005567972 2620 1639235
SGTC_581 0958-0271 211 µM -0.136900472428413 0.482826972084086 no 1752 0.445554732704523 2627 4591145
SGTC_2254 7938975 95.19 µM -0.137807867973342 0.482485327213596 no 1753 0.445196132975109 2834 2969277
SGTC_3211 9128781 49.47 µM -0.139817338353525 0.481728784616399 no 1754 0.444402156917795 2809 17194361
SGTC_654 1124-0271 80.9 µM -0.139889502976773 0.481701616669328 no 1755 0.444373647573029 2686 5403748
SGTC_2290 7904846 200 µM -0.140009545312564 0.481656424300979 no 1756 0.444326224304268 2725 2962154
SGTC_626 0214-0009 33 µM -0.14288186688394 0.480575152297809 no 1757 0.443191739876925 2760 3437874
SGTC_905 2-aminofluorene 215 µM -0.144334781437042 0.480028263344836 no 1758 0.44261805711734 2656 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2897 9048598 12.99 µM -0.146625107847251 0.479166242437506 no 1759 0.441713967337622 2682 6467404
SGTC_604 1000-0114 314 µM -0.146972247279553 0.479035596343103 no 1760 0.441576962935519 2756 1572745
SGTC_331 k048-0133 24.5 µM -0.147052899368699 0.479005243212009 no 1761 0.441545133235198 2670 6813582
SGTC_1299 1079-1439 3.74 µM -0.148207951615842 0.478570556790799 no 1762 0.441089328320784 2689 323161
SGTC_2035 5154463 94.595 µM -0.149892290484727 0.47793672719138 no 1763 0.440424797150431 2768 2769623
SGTC_1596 piperlongumine 63 µM -0.151164590107542 0.477457988020251 no 1764 0.439922941131389 2840 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_123 0083-0120 66.675 µM -0.15177189075867 0.477229485184157 no 1765 0.439683426594238 2682 16001701
SGTC_873 0591-4978 488 µM -0.152028858765158 0.47713280069694 no 1766 0.439582087101859 2878 3305145
SGTC_908 3448-7491 47.7 µM -0.152239111572067 0.477053693854479 no 1767 0.439499173448992 2699 1203031
SGTC_675 1309-0189 238 µM -0.152337050986601 0.477016844819813 no 1768 0.439460551733144 2720 4246530
SGTC_2339 9000433 200 µM -0.152597520693537 0.476918845831725 no 1769 0.439357840150318 2734 2988954
SGTC_1851 st056236 18.9 µM -0.1541908269252 0.476319411721913 no 1770 0.438729637375314 2686 5393171
SGTC_1725 st036284 20.55 µM -0.154856360201589 0.476069040397283 no 1771 0.43846727902541 2922 707914
SGTC_2881 9058953 51.95 µM -0.154859404274826 0.476067895249054 no 1772 0.438466079090296 2662 17122249
SGTC_3034 9090421 49.47 µM -0.155899527273726 0.475676623588009 no 1773 0.438056108967042 2656 17173761
SGTC_869 0564-0080 44.1 µM -0.156001644034445 0.475638210740784 no 1774 0.438015862668204 2724 6843321
SGTC_3184 9108758 49.47 µM -0.157025275964777 0.475253167843994 no 1775 0.437612463932839 2649 902885
SGTC_601 0986-0029 62.9 µM -0.157613303960441 0.475031989389481 no 1776 0.437380759785314 2702 24747981
SGTC_2935 9038016 29.96 µM -0.157942109510254 0.474908317159337 no 1777 0.437251207946332 2734 6463195
SGTC_1333 1482-0047 286 µM -0.158533392240768 0.474685926596675 no 1778 0.437018255076867 2683 3811116
SGTC_1448 4255-0083 152 µM -0.159558437227754 0.474300410082011 no 1779 0.436614460852337 2868 5399660
SGTC_3148 9097893 49.47 µM -0.160475028125801 0.473955703211686 no 1780 0.436253445675981 2712 17174100
SGTC_2543 pimpinellin 60.67 µM -0.161302995745264 0.473644342090553 no 1781 0.43592738194744 2692 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.162703300594103 0.473117787599706 no 1782 0.435376024061924 2799 5379071
SGTC_3257 9139206 32.98 µM -0.162774934236608 0.473090852565682 no 1783 0.435347822304742 2803 4910041
SGTC_1688 st021091 57.6 µM -0.16309330857077 0.47297114181991 no 1784 0.435222484122678 2683 3656366
SGTC_2343 7990716 14.84 µM -0.163425271672059 0.472846324212335 no 1785 0.435091803221018 2718 6456862
SGTC_86 0417-1630 471.922 µM -0.163949497120993 0.472649221696806 no 1786 0.434885450588512 2695 3634867
SGTC_1405 3909-7894 12 µM -0.164328344754326 0.472506783671748 no 1787 0.434736334552257 2803 7104060
SGTC_1892 st058411 7.36 µM -0.165229834972684 0.472167858186633 no 1788 0.434381541541264 2835 3934738
SGTC_2083 5306046 65.942 µM -0.165652043583273 0.472009130979109 no 1789 0.434215394092917 2735 539837
SGTC_3014 9081533 49.47 µM -0.16751436753016 0.471309053031311 no 1790 0.43348267180123 2814 21367265
SGTC_3219 9131112 49.47 µM -0.169761570088095 0.470464411153717 no 1791 0.43259882539921 2742 17612988 YMR079W SEC14
SGTC_1932 st074806 40.9 µM -0.17139361167777 0.469851069022829 no 1792 0.431957138800269 2953 17251235
SGTC_2642 cholecalciferol 100 µM -0.17155539779547 0.469790271600761 no 1793 0.431893537436396 2804 9821465 A vitamin D precursor, similar to steriods.
SGTC_1889 st059080 5.18 µM -0.171756614731779 0.469714657498846 no 1794 0.431814437491029 2708 176925 Isolated from Daphnopsis sellowiana.
SGTC_1290 0986-0249 10.2 µM -0.171839259735622 0.469683601146322 no 1795 0.431781949887921 2764 53329
SGTC_1677 st019204 53.9 µM -0.172235197950965 0.469534817983182 no 1796 0.431626313687746 2824 3945625
SGTC_2978 9011784 42.97 µM -0.173972464747419 0.468882049388118 no 1797 0.430943551079418 2863 2994934
SGTC_544 k015-0020 52.4 µM -0.174612659195384 0.468641520787103 no 1798 0.430692000405295 2749 3008304
SGTC_1987 st072290 61.9 µM -0.175355356041655 0.468362495173755 no 1799 0.430400208851228 2763 54697379
SGTC_2018 5133068 143 µM -0.17732161519729 0.46762386180921 no 1800 0.429627886674207 2714 785362
SGTC_2567 aureobasidin a 60 nM -0.179258591961548 0.466896337463295 no 1801 0.42886732948944 2994 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_177 1327-0068 8.361 µM -0.179465068959382 0.466818791622461 no 1802 0.428786271473252 2700 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_594 1487-1584 10.8 µM -0.179650598830115 0.466749113894787 no 1803 0.428713439368682 2747 5013332
SGTC_695 3505-6186 243 µM -0.179941759824985 0.466639767323695 no 1804 0.428599145321192 2844 1819379
SGTC_419 nsc-638432 893 µM -0.180044420504179 0.46660121333205 no 1805 0.428558847722427 2803 368090
SGTC_2704 st078022 71.1 µM -0.1828011739521 0.465566039012014 no 1806 0.427477013726536 2872 54697681
SGTC_2313 7726885 200 µM -0.183971034654944 0.465126820629492 no 1807 0.42701808902697 2843 726423
SGTC_1111 tnp00062 510.699 nM -0.184862933899727 0.464791990006269 no 1808 0.426668272154986 2872 676306
SGTC_144 4161-2749 112.381 µM -0.185103891448155 0.464701535663383 no 1809 0.426573774709395 2727 797501 YMR168C CEP3
SGTC_541 4513-1321 94 µM -0.186995084802255 0.463991654186873 no 1810 0.425832243366697 2768 747515
SGTC_2519 cryptotanshinone 88.04 µM -0.187635815676108 0.463751174264282 no 1811 0.425581074013257 2846 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1123 mangostin 811.285 nM -0.188781257741445 0.463321298556038 no 1812 0.425132130931886 2833 5281650 An antioxidant.
SGTC_709 3807-1509 243 µM -0.188860212470128 0.46329166901793 no 1813 0.425101189087189 2716 1886677 YPL242C IQG1
SGTC_2767 sibutramine 71.45 µM -0.189207684248019 0.4631612748388 no 1814 0.42496502264295 2889 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_949 1165-0505 146 µM -0.189415546409499 0.463083273226777 no 1815 0.424883570373641 2761 6244267
SGTC_897 1000-0139 31.4 µM -0.18953778385182 0.463037403503498 no 1816 0.424835672257978 2901 6151020
SGTC_375 3970-0961 9.27 µM -0.190272953354276 0.462761540795193 no 1817 0.424547623285563 2789 2898222
SGTC_1828 st055811 49 µM -0.190593097155066 0.462641416624702 no 1818 0.424422199364706 2881 5877589
SGTC_381 3461-2219 42.7 µM -0.190602290877541 0.462637967011781 no 1819 0.42441859761903 2849 2883159
SGTC_1386 3228-0095 33.8 µM -0.192998142959078 0.461739106428812 no 1820 0.423480211226461 2886 870181
SGTC_2741 miltefosine 3.04 µM -0.193987013520394 0.461368164950498 no 1821 0.423093025232018 2780 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_158 k038-0087 26.446 µM -0.194301143969192 0.461250336513103 no 1822 0.422970044973474 2741 X158
SGTC_2272 7805186 180 µM -0.194965721413575 0.461001068743639 no 1823 0.422709891489651 2765 2956062 YPR165W RHO1
SGTC_1434 4073-0095 163 µM -0.196726419365832 0.460340745618983 no 1824 0.422020817209293 2775 24133745
SGTC_250 brefeldin a 552.239 µM -0.197279572144837 0.460133316528429 no 1825 0.421804382138002 2744 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_105 0111-0055 734.78 µM -0.197347066778628 0.460108007172963 no 1826 0.421777974764013 2831 5179370
SGTC_2424 5537928 59.2 µM -0.201181048587131 0.458670596781264 no 1827 0.420278504788322 2782 5382802
SGTC_1277 0873-0036 22 µM -0.201311640557056 0.458621645535536 no 1828 0.420227450520117 2832 5965735
SGTC_2116 5511452 16.8835 µM -0.20253978324585 0.458161317902984 no 1829 0.419747380144996 2886 870744
SGTC_1072 oxiconazole 14.9 nM -0.202660727082121 0.458115989232797 no 1830 0.419700110690276 2770 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_535 2293-4129 48.2 µM -0.202873472585507 0.458036255439468 no 1831 0.419616964461665 2911 396118 YIL048W NEO1
SGTC_2315 7733312 200 µM -0.203056297006415 0.457967736963797 no 1832 0.419545515002358 2786 726316
SGTC_3290 9121031 71.43 µM -0.203228844834408 0.457903071069432 no 1833 0.419478084162676 2804 17014854
SGTC_2004 4023728 41.89 µM -0.203369065557704 0.457850521251878 no 1834 0.419423288337426 2884 360084 YDR527W RBA50
SGTC_2250 alverine citrate 130 µM -0.203682615562419 0.457733016355652 no 1835 0.419300764092152 2704 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.203748737888637 0.457708237056741 no 1836 0.419274926825794 2823 4330530
SGTC_3266 9136860 49.47 µM -0.204346798303577 0.457484121782989 no 1837 0.419041250839032 2765 4871271 YPR165W RHO1
SGTC_985 1493-0307 8.71 µM -0.205840070072144 0.456924597002595 no 1838 0.418457919984478 2889 3278274
SGTC_565 1418-0001 44.5 µM -0.206647394190904 0.456622130388547 no 1839 0.4181426219212 2942 2862145
SGTC_934 2950-0684 338 µM -0.207791514573912 0.456193525040324 no 1840 0.417695879200608 2997 1121253
SGTC_2679 rapamycin 1 nM -0.208835510451027 0.455802472353265 no 1841 0.417288324571476 2851 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_567 1080-0542 68.4 µM -0.210471703864548 0.455189684717594 no 1842 0.416649767039536 2774 5950415
SGTC_1236 0330-0013 258 µM -0.210750458049464 0.455085296206837 no 1843 0.416540999462394 2834 4617066
SGTC_2818 7996756 12.99 µM -0.211712427088393 0.454725079683166 no 1844 0.416165696224016 2745 2241621
SGTC_2061 5245884 80.95 µM -0.211956546632964 0.454633673198956 no 1845 0.416070467408347 2770 573863
SGTC_1419 3993-2473 62.6 µM -0.212403496696294 0.454466326445064 no 1846 0.415896129023479 2808 704026
SGTC_1337 1486-1011 40.3 µM -0.212647104351704 0.454375118425223 no 1847 0.415801113819161 2785 X1337
SGTC_2749 bexarotene 57.39 µM -0.213244697227986 0.454151386628606 no 1848 0.415568053293304 2871 82146 An retinoic acid receptor inhibitor.
SGTC_712 r015-0009 80.6 µM -0.213249391107373 0.454149629352447 no 1849 0.415566222803254 2902 6813872 YLR060W FRS1
SGTC_2429 5902844 64.44 µM -0.21337899044984 0.454101110813416 no 1850 0.415515683177121 2945 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_543 3844-1095 191 µM -0.215563183729083 0.453283510688411 no 1851 0.414664128096718 2883 4230703
SGTC_2214 7179297 48.276 µM -0.215868770262092 0.453169137441473 no 1852 0.414545020440212 2778 769744
SGTC_125 0133-0007 11.75 µM -0.216028507948601 0.453109353244112 no 1853 0.414482763029929 2900 26541
SGTC_2044 5102272 200 µM -0.216809145828926 0.452817203257249 no 1854 0.414178542073109 2886 592666
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.217387289855047 0.452600852077705 no 1855 0.413953267799602 2878 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_900 1112-0045 141 µM -0.218556022771165 0.452163535683803 no 1856 0.413497956639134 2814 56211 YIL048W NEO1
SGTC_652 0437-0092 114 µM -0.218673544233565 0.452119564714187 no 1857 0.413452179435494 2798 3091274
SGTC_293 4049-0273 38.5 µM -0.219862515682009 0.451674740983532 no 1858 0.412989115071485 2823 1380311
SGTC_2076 5212012 200 µM -0.220246245712404 0.451531190976911 no 1859 0.412839690944049 2740 604802
SGTC_888 0916-0002 6.97 µM -0.220568165840228 0.451410768395315 no 1860 0.412714345276767 2968 2802138 YIL048W NEO1
SGTC_2156 5649887 115 µM -0.221262797832231 0.451150938512159 no 1861 0.412443907559863 2904 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_16 erodoxin 22.806 µM -0.221632034045513 0.451012832737467 no 1862 0.412300171519275 2853 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1267 0828-0272 9.49 µM -0.221965860292551 0.45088797649015 no 1863 0.412170229971731 2934 745334
SGTC_848 0368-0089 85.6 µM -0.222136034059896 0.450824330703799 no 1864 0.412103993699623 2913 762535
SGTC_2998 9066762 71.4286 µM -0.222639235980753 0.450636138230958 no 1865 0.411908148441248 2955 4945196
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.223060779979654 0.450478493542678 no 1866 0.41174410118155 2821 115019
SGTC_783 0848-0141 92.7 µM -0.225336335185742 0.449627640354056 no 1867 0.410858817521471 2780 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2377 9073351 62.6 µM -0.225761750530068 0.449468598810546 no 1868 0.410693363846394 2786 7337946 YHR072W ERG7
SGTC_767 0929-0023 86 µM -0.22703103593235 0.448994124751126 no 1869 0.410199804511038 2824 1204563
SGTC_1753 st043925 64 µM -0.228533470053809 0.44843259122257 no 1870 0.409615769565243 2916 670181
SGTC_452 diindolylmethane 8 µM -0.229215369218989 0.448177765979158 no 1871 0.40935076382323 2916 3071 Inhibits expression of several cancer promoting factors.
SGTC_386 1509-0011 3.07 µM -0.230384419268625 0.447740942599217 no 1872 0.408896533589716 2798 3107280
SGTC_3030 9087619 49.47 µM -0.232485018087863 0.446956199365657 no 1873 0.408080661154489 2861 25236973
SGTC_164 4100-3994 89.624 µM -0.23257410346218 0.446922923354953 no 1874 0.40804606918221 2871 4615967
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.232775989398658 0.446847514395846 no 1875 0.407967679250771 3238 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2989 9073649 71.4286 µM -0.232864582200239 0.44681442358915 no 1876 0.407933280872094 2792 21367202
SGTC_777 1315-0167 517 µM -0.233147238550294 0.44670884946724 no 1877 0.407823537195315 2908 4221767
SGTC_1253 0550-0034 176 µM -0.233637418761292 0.446525772691593 no 1878 0.407633237805315 2940 5969915
SGTC_3178 9107506 49.47 µM -0.234564963237935 0.446179376518577 no 1879 0.407273203076516 2958 8897194
SGTC_2379 9035213 200 µM -0.235186451852844 0.445947301416297 no 1880 0.407032010486116 2964 646551
SGTC_312 4092-0653 6.84 µM -0.23526151420284 0.445919273027345 no 1881 0.407002882034744 2916 1148278
SGTC_847 0342-0274 5.54 µM -0.235417659190714 0.445860969131296 no 1882 0.406942290566787 2953 18097
SGTC_3162 9099653 49.47 µM -0.235852816056418 0.445698489529356 no 1883 0.406773441359232 2871 25237511
SGTC_1883 5-benzylidenerhodanine 20 µM -0.23616387996716 0.445582349551233 no 1884 0.406652753216632 2938 1273210
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.237515262446332 0.445077846702512 no 1885 0.406128540101547 2849 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2824 7998404 51.95 µM -0.237929748039415 0.444923127272215 no 1886 0.405967791175546 2804 837851
SGTC_8 0354-0001 70 µM -0.23798766690368 0.444901507951477 no 1887 0.405945329906894 2833 4993152
SGTC_17 0960-0276 49.807 µM -0.238734166937533 0.444622877267763 no 1888 0.405655860636599 2830 6821114
SGTC_2681 menadione 3.18 µM -0.238966666359908 0.444536102581327 no 1889 0.405565715189522 2894 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1706 st031321 9.9705 µM -0.239989140008943 0.444154521065672 no 1890 0.405169337820664 2935 6103185
SGTC_1638 st008370 60.6 µM -0.240009153034776 0.444147052830351 no 1891 0.405161580437743 2794 24207134
SGTC_547 1120-0019 610 nM -0.240105366953151 0.444111149082068 no 1892 0.405124286836956 2804 3676939
SGTC_1396 3511-0007 98.6 µM -0.240151924737217 0.444093775471829 no 1893 0.405106240823619 2957 X1396
SGTC_867 0518-0118 155 µM -0.241051959992994 0.443757937389335 no 1894 0.40475742267464 2864 6848158
SGTC_3116 9124943 49.47 µM -0.242189500155091 0.443333534818276 no 1895 0.404316665285983 2861 41905195 YPL160W CDC60
SGTC_1381 2324-0066 62.1 µM -0.243367460250915 0.442894120560811 no 1896 0.403860374540404 2954 10885928
SGTC_2915 7971052 15.16 µM -0.244554967754752 0.442451215920994 no 1897 0.403400517927656 2834 5741558
SGTC_40 0327-0103 19.753 µM -0.247282455152918 0.441434218200695 no 1898 0.402344817997684 2876 409036
SGTC_823 0417-1665 178 µM -0.247915293540575 0.441198306796536 no 1899 0.402099973347724 2945 3429856
SGTC_286 k060-0067 22.9 µM -0.24944675638362 0.440627489949125 no 1900 0.401507610767973 2872 5985051
SGTC_1847 st056231 15 µM -0.250326209124354 0.440299750250456 no 1901 0.401167544794661 2842 5393180
SGTC_2396 5342950 42.78 µM -0.250529636680504 0.440223946096371 no 1902 0.401088894266488 2940 1886677
SGTC_2930 9013230 14.89 µM -0.252352802408601 0.439544669523493 no 1903 0.400384188985892 2988 2995857
SGTC_255 tunicamycin 200.472 nM -0.254181922486749 0.438863353296279 no 1904 0.399677507918992 2934 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_542 3381-0244 89.3 µM -0.254617139442913 0.438701268953795 no 1905 0.399509410017727 3038 1112843
SGTC_153 4077-0274 519.67 µM -0.255574236674441 0.438344861144798 no 1906 0.399139806996995 3164 3121976
SGTC_2312 7706453 155.7 µM -0.256112303379614 0.438144515585823 no 1907 0.398932061012314 2900 976098
SGTC_1711 st032263 62.8 µM -0.256199432177751 0.438112075247331 no 1908 0.398898423529187 2894 3958979
SGTC_2898 9056270 58.44 µM -0.257366060751097 0.437677748958234 no 1909 0.398448100111206 2839 19154699
SGTC_276 colchicine 750 µM -0.257854306927283 0.437496001149985 no 1910 0.398259675178579 2976 2833 A microtubule depolymerizer.
SGTC_226 1,3-diallylurea 8.28947 mM -0.257993191342357 0.437444304354757 no 1911 0.398206080961238 2951 74537 YKL182W FAS1
SGTC_1132 3456-3614 2.5 µM -0.258017438575499 0.43743527894293 no 1912 0.398196724374033 3126 3125502
SGTC_1829 berberine 14.4 µM -0.258284685272292 0.437335805359149 no 1913 0.398093602382783 3027 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1850 st056238 17 µM -0.25858860600668 0.437222685913719 no 1914 0.397976337698501 2822 5393177
SGTC_2403 6032726 181.2 µM -0.258612513989784 0.437213787568361 no 1915 0.39796711344038 2940 2881040
SGTC_3232 9132874 49.47 µM -0.25974113342166 0.43679376135448 no 1916 0.397531730691204 2867 3784940
SGTC_3332 9141069 11.198 µM -0.260252987714666 0.43660329347493 no 1917 0.397334316854079 2842 17332883
SGTC_2799 7812892 81.82 µM -0.262607818373988 0.435727219267349 no 1918 0.396426436663936 3040 20205235
SGTC_2111 5486399 200 µM -0.262684410577108 0.435698729728148 no 1919 0.396396916744799 2876 689674
SGTC_371 0195-0006 7.36 µM -0.262807832584153 0.435652821891787 no 1920 0.396349349083843 2788 3928593
SGTC_2416 tofa 880 nM -0.263434085123704 0.43541989545477 no 1921 0.396108010987523 2889 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2944 9067346 25.62 µM -0.263557454361293 0.435374012520207 no 1922 0.396060473041961 3040 6473075
SGTC_2419 paclitaxel 166.5 µM -0.264809739707993 0.434908317504108 no 1923 0.395578016736556 2793 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1196 1588-0294 184 µM -0.264845450114654 0.434895038977564 no 1924 0.395564261263454 2926 6144269
SGTC_3265 9137266 49.47 µM -0.26515314706445 0.434780628255151 no 1925 0.395445743302495 2952 17224265
SGTC_2449 5812982 45.77 µM -0.266383422998465 0.434323230355137 no 1926 0.394971965340506 2930 776185
SGTC_50 0929-0078 56.389 µM -0.266581047091468 0.434249764898641 no 1927 0.394895874965356 2890 1377751
SGTC_3263 9137018 49.47 µM -0.267122716606545 0.434048414468599 no 1928 0.394687338784243 2924 43844957
SGTC_1045 1348-1485 165 µM -0.267484983677893 0.433913761403777 no 1929 0.394547887197368 2865 6810614
SGTC_1887 st057648 70.8 µM -0.267594771900155 0.433872955121619 no 1930 0.394505627834687 3022 688672
SGTC_1268 0828-0275 2.46 µM -0.267703954352688 0.433832374691952 no 1931 0.394463602874377 2980 745337
SGTC_101 0490-5701 117.494 µM -0.267762633582709 0.433810565354868 no 1932 0.394441017405265 2848 4661669
SGTC_2133 5320837 200 µM -0.270976503069086 0.432616374505554 no 1933 0.393204552105737 3038 2841355
SGTC_3241 9133421 49.47 µM -0.271068976450532 0.4325820228403 no 1934 0.393168990888567 2917 17018221
SGTC_460 trequinsin 123 µM -0.271414134285511 0.432453809403476 no 1935 0.39303626615957 2953 5537 A vasodilator.
SGTC_990 3985-0011 41.3 µM -0.271607243290974 0.43238207961453 no 1936 0.392962014712779 2933 5399565 YGL099W LSG1
SGTC_113 0099-0221 2.5 µM -0.271810096775763 0.432306732666655 no 1937 0.392884020655647 3075 89219
SGTC_1594 piperine 70.1 µM -0.271988600871998 0.432240431977779 no 1938 0.392815392122271 2867 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_976 1348-1067 47.6 µM -0.272333334737817 0.432112394980828 no 1939 0.3926828635341 2908 5310671 YGL099W LSG1
SGTC_23 0213-0011 39.996 µM -0.273071466615625 0.431838270715824 no 1940 0.392399139898309 3054 627608
SGTC_78 0336-0123 156.75 µM -0.27402576422762 0.431483916401892 no 1941 0.392032411104199 2824 6765896
SGTC_1912 st060209 90.8 µM -0.274573865134097 0.431280417882446 no 1942 0.391821823725656 2961 688787
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.275249785686429 0.431029487696343 no 1943 0.39156217004742 2899 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1808 st050063 61.5 µM -0.276103227046377 0.430712694084695 no 1944 0.391234391078772 3052 4011993
SGTC_1144 3486-0183 12.5 µM -0.276616276417092 0.430522273897773 no 1945 0.391037382715651 2903 6744069
SGTC_2479 5617353 43.85 µM -0.278144894438728 0.429955017556196 no 1946 0.390450567054663 3054 2731746
SGTC_3120 9124077 49.47 µM -0.278696391435464 0.429750397424891 no 1947 0.390238916027315 2906 18774327 YGL155W CDC43
SGTC_699 0375-0592 111 µM -0.280967131677971 0.428908091459173 no 1948 0.389367804933003 3004 762578
SGTC_2680 butyl paraben 22.24 µM -0.281433943457357 0.428734972777278 no 1949 0.389188793312687 2893 7184 An antifungal and steroid mimetic.
SGTC_298 1391-0729 10 µM -0.281927550202154 0.428551932008337 no 1950 0.388999532017804 2902 3237558
SGTC_418 lividomycin a 100 µM -0.282001842283106 0.428524384120344 no 1951 0.388971048836438 3021 72394 An antibiotic.
SGTC_1017 4239-0030 168 µM -0.282493893020799 0.428341937958916 no 1952 0.38878241432052 2908 1149593
SGTC_2450 5739737 12.93 µM -0.283616427030959 0.427925773994753 no 1953 0.38835217344631 3001 2262825
SGTC_2054 5233173 129 µM -0.284654210597129 0.42754110138568 no 1954 0.387954537246119 3075 6889
SGTC_995 3931-2021 34.6 µM -0.285879568040248 0.427086989936384 no 1955 0.387485181650408 3010 730143
SGTC_1148 3909-7663 27.7 µM -0.285930348779531 0.427068172924446 no 1956 0.387465734359434 3043 4084526
SGTC_2593 nobiletin 86.24 µM -0.28929089355751 0.425823280120831 no 1957 0.386179390216082 2991 72344 An anti-infammatory.
SGTC_967 1306-0166 352 µM -0.29005169959622 0.425541546421269 no 1958 0.385888343100528 3078 4437607
SGTC_2838 9002687 71.43 µM -0.291285391107192 0.42508477959633 no 1959 0.385416529737906 2888 6457060
SGTC_1701 st028638 40.4 µM -0.291949951118579 0.424838771899964 no 1960 0.385162445412536 3035 3490878
SGTC_1409 3909-8004 61.9 µM -0.292682093691927 0.424567780291437 no 1961 0.384882579001683 2953 2119279
SGTC_585 0kpi-0023 191 µM -0.292914481304724 0.42448177294464 no 1962 0.384793759808286 3045 64601
SGTC_2965 9082772 38.63 µM -0.293188409758222 0.424380395826662 no 1963 0.384689071353456 3113 16459634
SGTC_2 0422-0095 29 µM -0.2932513698691 0.424357095870436 no 1964 0.384665010795994 2966 6790840
SGTC_2782 7736369 71.43 µM -0.293486138645349 0.424270216172269 no 1965 0.384575296516272 2967 2950836 YOL077C BRX1
SGTC_650 1328-0195 38 µM -0.294710056428791 0.423817346775072 no 1966 0.384107690145123 3015 2780821
SGTC_1895 st058434 18.3 µM -0.295697644432482 0.423451996528168 no 1967 0.383730498129325 3088 5393175
SGTC_578 3460-0051 92 µM -0.296286914786996 0.423234032020402 no 1968 0.383505489034438 3029 2876744
SGTC_1793 st048256 72.231 µM -0.297075253600496 0.422942471066291 no 1969 0.383204528369741 2899 672022
SGTC_1939 st074455 53.6 µM -0.297179119166287 0.42290406034082 no 1970 0.383164881317125 3152 1644229
SGTC_1219 1469-0211 33.1 µM -0.299025790219787 0.422221262039233 no 1971 0.382460183792829 3052 6822282
SGTC_1125 tnp00248 1.32998 µM -0.299567704770425 0.422020935835075 no 1972 0.382253460630631 3091 24207736
SGTC_1379 2144-0755 36.5 µM -0.300004358894702 0.421859535276667 no 1973 0.382086915382806 3110 5392327
SGTC_1215 3852-0577 11.2 µM -0.300085418236287 0.421829574738233 no 1974 0.382056000753952 3088 2884876
SGTC_2869 9037858 32.47 µM -0.301194880282746 0.421419549347404 no 1975 0.381632946807259 2902 27187042
SGTC_2728 chlorpromazine 9.18 µM -0.302533049608452 0.42092511368197 no 1976 0.381122871561088 2918 2726 A thorazine and dopamine antagonist.
SGTC_2433 5607874 27.82 µM -0.30254114622834 0.420922122467979 no 1977 0.381119785968284 2938 2252428
SGTC_3197 9113331 49.47 µM -0.302597051660142 0.42090146889855 no 1978 0.381098480814987 3173 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2888 9058547 12.99 µM -0.303189617796964 0.420682566071582 no 1979 0.380872680339499 2936 16476514
SGTC_2205 7238770 200 µM -0.303461529863462 0.42058212587676 no 1980 0.380769080374578 3063 279867
SGTC_2299 7976368 114.88 µM -0.304730164162612 0.420113580037289 no 1981 0.38028583695079 3082 2979718
SGTC_553 k007-0256 45.7 µM -0.306438758527704 0.419482722350637 no 1982 0.379635300892705 2999 6287000
SGTC_1506 4226-2149 212 µM -0.306734530543906 0.419373536556394 no 1983 0.379522722171587 3046 991114
SGTC_321 4534-3890 65.3 µM -0.306994255815968 0.419277662726081 no 1984 0.379423872224651 3053 699746
SGTC_829 1635-0120 117 µM -0.308001320295392 0.418905964796475 no 1985 0.379040663848006 3081 285054
SGTC_1352 1496-0991 99 µM -0.308246837623019 0.418815357644727 no 1986 0.378947257550674 2937 3000039
SGTC_2092 5303694 80.6725 µM -0.309237671989353 0.418449738136177 no 1987 0.378570369602983 2975 1963699
SGTC_770 0389-1121 67.2 µM -0.313252228712781 0.416969084219359 no 1988 0.377044520434404 3132 6753108
SGTC_79 0052-0007 94.094 µM -0.313348295434241 0.416933667104826 no 1989 0.377008030884901 3115 2801472
SGTC_438 sphingosine 6.67 µM -0.313709013279098 0.416800686540073 no 1990 0.376871027256125 2941 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_999 SEC7.066 22.7 µM -0.314055075548088 0.416673117778844 no 1991 0.376739604506926 2956 740511 YDR170C SEC7
SGTC_2699 st077704 54.6 µM -0.315874802111324 0.416002457572866 no 1992 0.376048769227772 3025 645852
SGTC_1921 5740136 50 µM -0.316414674409092 0.415803534590424 no 1993 0.375843890069379 3156 1774243
SGTC_1445 4239-0156 97.7 µM -0.316794037163929 0.415663766342206 no 1994 0.375699944507378 3141 4008346
SGTC_1561 5-methoxyflavone 52.9 µM -0.316990365423029 0.41559143750216 no 1995 0.375625456422253 2974 94525
SGTC_1635 st007035 42.4 µM -0.319671070611852 0.41460413220356 no 1996 0.374608846115164 3035 3716403
SGTC_91 0417-1751 58.384 µM -0.319769790886013 0.414567783725364 no 1997 0.374571424771538 2977 6795624
SGTC_1035 k081-0041 55.2 µM -0.319983932828805 0.414488939885709 no 1998 0.374490255240687 3123 731709
SGTC_1165 k072-0275 30.3 µM -0.32082176701075 0.414180495090515 no 1999 0.374172731479233 3093 6153523 YGL055W OLE1
SGTC_612 0302-0167 22.4 µM -0.321447253961146 0.413950259443415 no 2000 0.373935739041512 3039 235821
SGTC_2103 5378138 10 µM -0.322432781923717 0.413587556246248 no 2001 0.373562426402402 2987 244142
SGTC_2580 diallyl disulphide 81.36 µM -0.322783884769935 0.41345835789393 no 2002 0.373429459188803 2953 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1086 cerivastatin 2.18 µM -0.322885734625521 0.413420881073902 no 2003 0.373390890142945 3013 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1137 ixabepilone 100 µM -0.322989017703743 0.413382877688706 no 2004 0.37335177965196 2938 154225 A novel microtubule stabilizer.
SGTC_3305 9127027 53.8275 µM -0.323404672148344 0.413229944328036 no 2005 0.373194395819708 3000 41905295
SGTC_2652 actinonin 100 µM -0.324287869298567 0.412905029890824 no 2006 0.372860051391758 2955 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2537 larixol 68.93 µM -0.324297609510302 0.412901446951233 no 2007 0.372856364656058 3002 6708759
SGTC_3339 9145883 14.936 µM -0.324332716223182 0.412888532997363 no 2008 0.372843076625571 3113 2030670
SGTC_1079 idarubicin 2.36 µM -0.324399412356996 0.412863999180099 no 2009 0.372817832290366 3112 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_362 0310-0100 9.03 µM -0.324543337703718 0.412811058168375 no 2010 0.372763358734578 3097 790235
SGTC_978 1416-0512 87.4 µM -0.324966555498642 0.412655392360326 no 2011 0.372603191978079 3050 6814003
SGTC_3135 9127742 49.47 µM -0.327029900053221 0.411896660671251 no 2012 0.37182263526376 3031 3643468
SGTC_2921 7974240 10.71 µM -0.327132708551 0.411858864586943 no 2013 0.371783756880752 3107 2979074 YDR527W RBA50
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.327577450242974 0.411695371043452 no 2014 0.371615587038991 2955 2333 A French combination drug.
SGTC_2417 cerulenin 830 nM -0.328953745916194 0.411189521890315 no 2015 0.371095324732923 3100 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2526 patulin 37.61 µM -0.329761437785346 0.410892728310687 no 2016 0.370790113572401 3141 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1934 st074720 32.6 µM -0.329842011752506 0.410863123483094 no 2017 0.370759670681865 2963 17250992
SGTC_2072 5231554 129 µM -0.329871073022171 0.410852445793136 no 2018 0.370748690794851 3101 789545
SGTC_2159 5658611 73.75 µM -0.329944327217485 0.410825531034226 no 2019 0.370721014467447 3097 793844
SGTC_1731 st035964 63 µM -0.331095373209455 0.410402673598773 no 2020 0.370286223188196 2996 6739575
SGTC_643 k048-0106 28.4 µM -0.331781544171003 0.41015064587382 no 2021 0.370027110635125 3075 6763920
SGTC_2729 fluphenazine 10.66 µM -0.33207667335079 0.41004225756662 no 2022 0.369915681798007 2978 3372 An atypical antipsychotic.
SGTC_2135 5326629 150.42 µM -0.332258519543197 0.409975476670091 no 2023 0.369847029470018 3032 5020077
SGTC_2317 5986382 200 µM -0.332436635039777 0.409910068359391 no 2024 0.369779789611351 3060 877883
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.333178169673602 0.40963778590069 no 2025 0.369499897858583 3093 140250 A respiratory chain inhibitor.
SGTC_802 4112-3352 742 µM -0.33334277032739 0.409577352456733 no 2026 0.369437778824088 3134 704594
SGTC_1246 0422-0085 105 µM -0.333703967295984 0.409444745832654 no 2027 0.369301477783652 3138 264295
SGTC_2168 5727979 200 µM -0.335937930778832 0.408624819210139 no 2028 0.368458836468213 2975 695210
SGTC_2334 9017922 200 µM -0.336495171003705 0.408420358735422 no 2029 0.368248746239042 3125 3163164
SGTC_2808 7946468 45.46 µM -0.336881533977379 0.408278610524856 no 2030 0.368103103123981 3067 2970879
SGTC_1183 1254-0324 198 µM -0.336904945743871 0.40827002164003 no 2031 0.368094278449847 3133 5799357
SGTC_2861 9024595 19.48 µM -0.336965737897904 0.408247719521501 no 2032 0.36807136418835 3030 16482810
SGTC_698 k064-0052 127 µM -0.337548477808932 0.40803395152037 no 2033 0.367851737059202 3058 5088751
SGTC_214 4373-3496 70 µM -0.338077371037652 0.407839959930474 no 2034 0.367652441440024 3052 3779166
SGTC_366 0181-0206 4.31 µM -0.338452465221264 0.407702393645872 no 2035 0.367511121410004 3194 274874
SGTC_3028 9087778 49.47 µM -0.338462385445944 0.407698755544825 no 2036 0.367507384121601 2995 17217395
SGTC_789 1309-1135 70.6 µM -0.339370992944559 0.407365570482187 no 2037 0.367165133807656 2977 3092424
SGTC_82 0054-0107 293.755 µM -0.340071441041547 0.40710876289927 no 2038 0.366901364083672 3064 3104697
SGTC_2325 6158266 200 µM -0.341775981350755 0.406483988714615 no 2039 0.366259743196158 3076 3623240
SGTC_175 3793-3120 23.7 µM -0.342426474332145 0.406245622733388 no 2040 0.366014983882483 3003 5322297
SGTC_1748 st037455 53.6035 µM -0.345081282576454 0.405273158674731 no 2041 0.365016632251355 3179 580690
SGTC_680 0417-1641 114 µM -0.346114903939143 0.404894697892783 no 2042 0.364628181573035 2982 2835990
SGTC_3352 9151559 45.5865 µM -0.346937507942939 0.404593564720746 no 2043 0.364319133710662 3081 17159339
SGTC_180 1486-1293 102.781 µM -0.348119739101693 0.404160880729146 no 2044 0.363875130369237 3172 4140536
SGTC_1113 artemisinin 1.17947 µM -0.34836009119866 0.404072928746382 no 2045 0.363784885128251 3126 2240 An anti-malaria and mitochondrial poison.
SGTC_1794 st048918 76.9 µM -0.348926679452601 0.403865616443708 no 2046 0.363572177580632 3097 672303
SGTC_3324 9138759 60.749 µM -0.350924522565855 0.40313482973405 no 2047 0.362822486827786 3158 45595710
SGTC_858 0438-0351 2.77 µM -0.351591116578429 0.402891072869756 no 2048 0.362572464154609 3057 2799119
SGTC_2658 polymyxin b sulfate 77.05 µM -0.351779380834996 0.40282223613999 no 2049 0.362501861566377 3036 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2970 9090938 41.86 µM -0.352631938432502 0.402510545680979 no 2050 0.362182195215975 3225 17217104
SGTC_634 1611-4317 11.2 µM -0.353692653688997 0.402122840427298 no 2051 0.361784614349167 3127 2843522
SGTC_2568 diosmetin 100 µM -0.354092547602998 0.401976698959625 no 2052 0.3616347634534 3190 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_379 3970-0972 5.9 µM -0.3549939595245 0.401647327728966 no 2053 0.361297058257444 3076 2898042 YBL034C STU1
SGTC_2319 6033012 152.6 µM -0.356314984524127 0.401164758321911 no 2054 0.360802344374765 3031 847246
SGTC_1217 1183-1422 255 µM -0.357695825765364 0.400660499222074 no 2055 0.360285478632137 3174 2849664
SGTC_478 N-arachidonylglycine 10 µM -0.358776352901404 0.400266024965349 no 2056 0.359881202084956 3120 5283389
SGTC_523 1934-0222 13.7 µM -0.359473591753742 0.400011533939436 no 2057 0.35962041505042 3041 1361595
SGTC_3284 9108171 64.8615 µM -0.360623014018589 0.39959208945636 no 2058 0.359190641370051 3114 8687505
SGTC_2258 7960471 200 µM -0.361048106472678 0.399436995033329 no 2059 0.359031742653921 3106 2974708
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.361562383234654 0.399249383046917 no 2060 0.358839539619315 3148 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_632 0781-2353 4.65 µM -0.362316667222565 0.398974256740463 no 2061 0.358557702228835 3125 6811515 YHR007C ERG11
SGTC_1630 st005209 31.3 µM -0.362372664292863 0.398953833717781 no 2062 0.358536782053684 3152 3367314
SGTC_2531 methyl deoxycholate 70.07 µM -0.363154636835217 0.398668664815111 no 2063 0.358244686105072 3008 16667744 Haematoxylin.
SGTC_1184 1269-1718 139 µM -0.364255762848326 0.398267199112241 no 2064 0.357833515070576 3191 5403821
SGTC_2367 9070478 135.38 µM -0.364563572377531 0.398154992347693 no 2065 0.357718605504109 3001 572802
SGTC_3070 9117005 49.47 µM -0.367741582066407 0.396996996539538 no 2066 0.35653296591772 3129 8779016
SGTC_2858 9025781 8.96 µM -0.368035445117618 0.396889965087618 no 2067 0.356423402413203 3135 4894980 YPL153C RAD53
SGTC_2836 9010338 19.48 µM -0.368371802733423 0.396767465704163 no 2068 0.356298009835798 3040 2994051
SGTC_1109 tnp00067 928.257 nM -0.36862815993355 0.396674108822116 no 2069 0.356202451478577 3080 676295
SGTC_2210 7115885 190.385 µM -0.368871725423858 0.396585415747588 no 2070 0.356111669656793 3072 2927039
SGTC_3268 9137683 49.47 µM -0.369329046017638 0.396418899349892 no 2071 0.355941238988753 3029 1953228
SGTC_1874 staurosporine 7.6 µM -0.369568346830899 0.396331774327381 no 2072 0.355852069699582 3167 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1433 4060-0023 7.6 µM -0.370263754549923 0.396078618569503 no 2073 0.355592988680763 3175 3840627
SGTC_2676 harmalol 100 µM -0.372183455760605 0.395379999589922 no 2074 0.354878131564473 3154 5459187 A monoamine oxidase inhibitor
SGTC_2395 5646831 180.19 µM -0.374406497841054 0.394571408650272 no 2075 0.354050954676672 3232 6808628
SGTC_2993 9054257 71.4286 µM -0.375202574318728 0.394281960597806 no 2076 0.353754907896584 3026 6470217 YGL055W OLE1
SGTC_2540 epiandrosterone 100 µM -0.37545807736073 0.394189073776199 no 2077 0.353659909562702 3075 441302 A steroid.
SGTC_865 0488-0499 301 µM -0.376003159458075 0.393990932092105 no 2078 0.353457273590676 3229 9634651
SGTC_172 1112-0046 2.638 µM -0.376787918419392 0.393705714156383 no 2079 0.353165609939478 3068 2802135 YIL048W NEO1
SGTC_2663 amphotericin b 100 µM -0.377229645337119 0.393545195101991 no 2080 0.353001475555472 3123 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1443 4112-3303 14 µM -0.377759980064962 0.393352500773281 no 2081 0.352804452912889 3076 704433
SGTC_3019 9081971 49.47 µM -0.378405118361678 0.393118128391399 no 2082 0.352564833244275 3238 16451803
SGTC_704 1310-0270 142 µM -0.380126633651805 0.392492908665689 no 2083 0.351925708135672 3113 5718033
SGTC_718 1130-0073 349 µM -0.380877968632124 0.392220125758416 no 2084 0.351646900506145 3235 6740020
SGTC_1721 st082152 9.2685 µM -0.38242244067466 0.391659549552255 no 2085 0.351074023896028 3044 5296051
SGTC_2079 5212404 121 µM -0.38252954518064 0.391620683597987 no 2086 0.351034309149292 3212 758462
SGTC_856 0433-0016 11.3 µM -0.382988721338706 0.391454070571094 no 2087 0.3508640633782 3157 3911780
SGTC_1182 1222-0449 220 µM -0.383124795582349 0.391404699571318 no 2088 0.350813617760846 3148 658318
SGTC_2300 7976697 71.57 µM -0.385601683445656 0.39050633173176 no 2089 0.349895843133697 3039 2236109
SGTC_2310 7668677 200 µM -0.385671016734862 0.390481192914492 no 2090 0.349870165279297 3299 2197143
SGTC_3098 9119039 49.47 µM -0.386128400069488 0.390315366650295 no 2091 0.349700788785202 3105 17161528
SGTC_288 1315-0019 35.1 µM -0.386182981313304 0.390295579321333 no 2092 0.349680578459203 3182 6811474
SGTC_1211 1056-0033 32.3 µM -0.38648127148053 0.390187445259917 no 2093 0.349570135195773 3215 6741922
SGTC_2207 7258803 200 µM -0.386788990023539 0.390075902192695 no 2094 0.349456214375843 3158 3666799
SGTC_1438 4092-1045 4 µM -0.387095592954294 0.389964772518004 no 2095 0.34934272005259 3085 1351342
SGTC_3115 9123671 49.47 µM -0.387543453706242 0.389802459446377 no 2096 0.34917696093831 3210 3286988
SGTC_64 000l-0018 272.079 µM -0.387675517496652 0.389754600738202 no 2097 0.349128087895336 3016 6811119
SGTC_1788 fluconazole 20 µM -0.388350191689689 0.389510131086024 no 2098 0.348878449273266 3180 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_408 cantharidin 100 µM -0.388486908615237 0.389460596736476 no 2099 0.348827870118391 3103 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_285 1486-1325 46 µM -0.390008980785287 0.388909251333004 no 2100 0.348264953024887 3203 22310230
SGTC_640 3381-0960 37.1 µM -0.392410446061675 0.388039815552287 no 2101 0.347377484456159 3168 1745025
SGTC_2634 4'-methoxyflavone 100 µM -0.392823690336039 0.387890259439037 no 2102 0.347224852995605 3152 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1811 st050069 61.5 µM -0.393612182987564 0.387604944354143 no 2103 0.346933692583734 3199 3877702
SGTC_245 methotrexate 289.6 µM -0.394346842041361 0.387339163495925 no 2104 0.346662492181599 3165 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.394639315133672 0.387233368897233 no 2105 0.346554547192237 3096 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1242 0402-0103 60.1 µM -0.395398199349484 0.386958901179591 no 2106 0.346274518868382 3058 432868
SGTC_1477 0139-0234 16 µM -0.398017183274385 0.386012121026212 no 2107 0.345308759756612 3157 620880
SGTC_484 loperamide 105 µM -0.398554890512856 0.385817820041659 no 2108 0.345110602722347 3115 3955 An opioid-receptor agonist.
SGTC_1355 1499-0035 1.68 µM -0.398614030872001 0.385796451368341 no 2109 0.345088810780362 3094 1548538
SGTC_3036 9090181 49.47 µM -0.399211790866463 0.385580487395178 no 2110 0.344868578011924 3087 25236586
SGTC_2507 purpurin 79.67 µM -0.399464232435391 0.385489293739551 no 2111 0.344775586720093 3079 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1325 1431-0015 227 µM -0.399699081409865 0.385404461032494 no 2112 0.344689084389199 3099 1103340
SGTC_728 3030-5151 22.5 µM -0.399886455553353 0.385336781229128 no 2113 0.344620074368471 3099 3125388
SGTC_2227 7312221 64.1025 µM -0.400697120926685 0.385044008019527 no 2114 0.344321565379867 3124 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1957 st077035 62.4 µM -0.401331957491682 0.384814781426535 no 2115 0.344087869009518 3219 705593
SGTC_1117 retinoic acid 1.10837 µM -0.402747456947358 0.384303818373146 no 2116 0.343567009081351 3259 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1810 st050138 53 µM -0.403348133505993 0.384087048509188 no 2117 0.343346068388079 3236 3444541
SGTC_1484 3473-2379 286 µM -0.404392369996124 0.383710294762662 no 2118 0.342962105038376 3225 671917
SGTC_1875 nocodazole 6 µM -0.405923199359029 0.383158180208773 no 2119 0.342399515722802 3253 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3193 9111931 49.47 µM -0.406071119566263 0.383104843314884 no 2120 0.342345172625151 3093 17087244
SGTC_1050 3232-1156 69.3 µM -0.406406320856446 0.382983985031125 no 2121 0.342222038066329 3155 700529
SGTC_628 1636-0253 16 µM -0.406997380813142 0.382770903549405 no 2122 0.342004955945546 3183 4456143
SGTC_106 0092-0003 11.579 µM -0.408322805483699 0.382293207230008 no 2123 0.341518349233928 3160 1072148
SGTC_503 tyrphostin 8 294 µM -0.409387118893512 0.381909747627147 no 2124 0.34112779555493 3203 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_476 mead acid 10 µM -0.412240589962518 0.380882248078803 no 2125 0.340081544505916 3120 5312531 An omega 9 fatty acid.
SGTC_3279 9140807 49.47 µM -0.413381881772008 0.380471517658908 no 2126 0.33966342347862 3180 45595718
SGTC_1907 st060210 83.7 µM -0.413987215038457 0.38025372373348 no 2127 0.339441734996805 3267 688793
SGTC_3159 9100096 49.47 µM -0.414645178955886 0.380017036788474 no 2128 0.339200834833048 3063 25236875
SGTC_2305 7443522 69.23 µM -0.414787914355056 0.379965697035011 no 2129 0.339148583828323 3122 5415886
SGTC_536 3852-0578 10.6 µM -0.415915281263852 0.379560274694948 no 2130 0.338735998528641 3270 2869208
SGTC_2322 7413319 38.22 µM -0.418119295746834 0.378768052392593 no 2131 0.337929948886294 3235 1840400
SGTC_2374 9071832 200 µM -0.418172507435486 0.378748931990439 no 2132 0.337910497534806 3247 17381698
SGTC_230 MPP+ 141.667 µM -0.419117571317634 0.378409394400336 no 2133 0.33756510480151 3192 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1867 st057372 64 µM -0.419402427517953 0.378307071156889 no 2134 0.337461025150293 3215 688837
SGTC_485 niflumic acid 177 µM -0.420891531550958 0.377772308904372 no 2135 0.336917144654186 3252 4488 A COX2 inhibitor.
SGTC_358 0075-0058 9.45 µM -0.420967208560177 0.377745138264335 no 2136 0.336889513467022 3371 1069125
SGTC_2945 9067681 61.76 µM -0.421609685742884 0.377514491314375 no 2137 0.336654967690557 3224 16456930
SGTC_1271 0832-2808 169 µM -0.421930156735649 0.377399459725131 no 2138 0.336537998766155 3266 3663794
SGTC_2693 st077581 40.7 µM -0.421974029395372 0.377383712681816 no 2139 0.336521986884933 3263 25238761
SGTC_200 k038-0079 37.545 µM -0.424213988814335 0.376580004191037 no 2140 0.335704879885094 3134 3436683
SGTC_510 ag-490 170 µM -0.424970192110882 0.376308795268572 no 2141 0.335429202172223 3265 5328779
SGTC_1311 1190-0148 100 µM -0.425395742785206 0.3761562002671 no 2142 0.3352741044759 3290 1961333
SGTC_742 0kpi-0133 140 µM -0.425620772181959 0.376075516499148 no 2143 0.335192100816558 3284 2728852
SGTC_665 3914-0008 307 µM -0.425679543153113 0.376054445195726 no 2144 0.335170685198247 3136 1069549
SGTC_3229 9132204 49.47 µM -0.425847443537061 0.37599424948664 no 2145 0.33510950674597 3135 17682924
SGTC_2823 7987624 58.44 µM -0.426358199857039 0.375811151492866 no 2146 0.334923427570426 3371 2239440
SGTC_247 mechlorethamine 29.705 µM -0.426505964269663 0.375758185520544 no 2147 0.33486960146908 3137 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1262 0737-0114 49.6 µM -0.427370607923438 0.375448302021612 no 2148 0.334554705995972 3320 765919
SGTC_590 k048-0076 22.4 µM -0.427711665611887 0.375326090919467 no 2149 0.334430527826074 3255 6832814
SGTC_1412 3909-8563 178 µM -0.428696888505401 0.374973126603085 no 2150 0.334071912648168 3270 23767530
SGTC_3072 9116419 49.47 µM -0.43019078183507 0.374438126658778 no 2151 0.333528433493925 3194 17170162
SGTC_2464 5717415 7.67 µM -0.430202623538478 0.374433886817573 no 2152 0.333524126869706 3163 5285744
SGTC_792 4534-1957 155 µM -0.431228480277922 0.374066643487741 no 2153 0.333151123716381 3149 1717904
SGTC_1107 amlodipine 47 µM -0.432171898249709 0.373729013009925 no 2154 0.332808241042291 3225 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2717 st081029 62.2815 µM -0.433280981553273 0.373332218116465 no 2155 0.33240532651849 3271 5292846
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.435081866954028 0.372688204535336 no 2156 0.331751502444792 3208 688788
SGTC_3169 9102970 49.47 µM -0.435426020036605 0.372565172582503 no 2157 0.331626613483731 3263 17027839
SGTC_3146 9095609 49.47 µM -0.43576002048901 0.372445782544985 no 2158 0.331505426682028 3206 17173999
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.436909673492697 0.372034927421227 no 2159 0.331088428103595 3136 442882
SGTC_1138 3761-0006 1.03 µM -0.43764112141207 0.371773603352277 no 2160 0.330823228547873 3266 12061087
SGTC_920 mycophenolic acid 780.421 nM -0.43861702495656 0.371425034729751 no 2161 0.330469529414332 3166 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_110 0850-0284 111.64 µM -0.440232156554444 0.370848381368608 no 2162 0.329884485968587 3073 3906265
SGTC_3090 9117696 49.47 µM -0.441084597548428 0.370544149629972 no 2163 0.329575876836568 3202 7923821
SGTC_1314 1222-0010 41.1 µM -0.441499535865586 0.370396089588039 no 2164 0.329425698726105 3217 3526027
SGTC_316 k060-0003 58.6 µM -0.441731129626504 0.370313459670963 no 2165 0.329341890244048 3284 6152314
SGTC_355 1311-2252 105 µM -0.444072619849394 0.369478380314333 no 2166 0.328495040652615 3193 5338538
SGTC_1437 4092-1038 11.6 µM -0.444555621985248 0.369306196745199 no 2167 0.328320462062104 3194 3977136
SGTC_447 ml7 120 µM -0.444784778881357 0.369224514653717 no 2168 0.328237647611011 3279 4216 Selective myosin light chain kinase inhibitor.
SGTC_1780 st038448 24.544 µM -0.446310644081907 0.368680776593842 no 2169 0.327686434293569 3340 728868 YDL195W SEC31
SGTC_3182 9108849 49.47 µM -0.44816593522686 0.368020002551348 no 2170 0.3270167226598 3291 17133045
SGTC_1597 7-benzyloxygramine 47.5 µM -0.44962013021253 0.367502354270258 no 2171 0.326492185291395 3241 260807
SGTC_1955 wogonin 32.4 µM -0.452614431504478 0.366437234777778 no 2172 0.32541320256036 3394 5281703 A flavanone.
SGTC_103 0844-0104 51.839 µM -0.454755059005468 0.365676409905257 no 2173 0.324642732589116 3313 5375804
SGTC_1742 st038235 28.8875 µM -0.455309984474883 0.365479263579666 no 2174 0.324443122087842 3277 564103 YBR002C RER2
SGTC_759 3486-0358 89.3 µM -0.456049771884363 0.36521649730285 no 2175 0.324177093910381 3364 875103
SGTC_812 4251-0442 148 µM -0.457168976177083 0.364819085624851 no 2176 0.323774797714041 3304 5723007
SGTC_2163 5671233 125 µM -0.458389628687023 0.364385816834118 no 2177 0.323336270745459 3398 701023
SGTC_1279 0874-0590 65.2 µM -0.460269470219539 0.363718908832513 no 2178 0.322661405999677 3259 3523074
SGTC_2357 9067248 200 µM -0.460474738129184 0.363646111261384 no 2179 0.322587749953678 3292 9150235
SGTC_2610 ononetin 44.17 µM -0.460569222167433 0.363612604470467 no 2180 0.32255384869536 3281 259632
SGTC_1327 1436-0082 2.18 µM -0.461333348449386 0.363341661396733 no 2181 0.322279731298604 3218 15992205
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.46225967678188 0.363013296565072 no 2182 0.321947556221145 3269 5355888
SGTC_539 4859-0462 2.54 µM -0.462544830899363 0.362912235399607 no 2183 0.321845330498114 3329 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3086 9117350 49.47 µM -0.464653844771847 0.362165078881024 no 2184 0.321089683066964 3252 2679265
SGTC_43 0570-0105 72.5 µM -0.464778286620996 0.362121009463897 no 2185 0.321045119373166 3219 1114046 YDL195W SEC31
SGTC_3045 9092950 49.47 µM -0.465380521397043 0.361907761904298 no 2186 0.32082949036167 3367 44120432
SGTC_1078 idebenone 36.1 µM -0.466305921685865 0.361580167023281 no 2187 0.320498270339563 3288 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_861 0443-0273 110 µM -0.466605567588696 0.361474113073105 no 2188 0.320391051450545 3303 6149169
SGTC_557 1315-0110 16.2 µM -0.467612149656094 0.361117930519609 no 2189 0.320030987422956 3201 6833801
SGTC_1690 st023502 41.2 µM -0.46836403162654 0.360851953002193 no 2190 0.319762142591255 3310 24207482
SGTC_1292 0kpi-0043 232 µM -0.468965004969505 0.360639407639945 no 2191 0.319547325093762 3275 3333905
SGTC_1993 st073995 70.8 µM -0.469107753176964 0.360588928414449 no 2192 0.319496308742468 3267 3098394
SGTC_2141 5621638 7.665 µM -0.469494583792291 0.360452147948022 no 2193 0.319358077689869 3335 2856238
SGTC_1293 1000-1278 195 µM -0.470577757445078 0.360069240742968 no 2194 0.318971147222414 3350 678847
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.47087785924246 0.359963178097955 no 2195 0.318863979953919 3321 17037758
SGTC_2544 sphondin 68.51 µM -0.470932056977221 0.359944024563012 no 2196 0.318844627391405 3373 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3353 9151644 39.2805 µM -0.471893031906226 0.359604473476211 no 2197 0.318501570991957 3346 4909158
SGTC_1621 st003705 32.4 µM -0.472078305418316 0.359539021626673 no 2198 0.318435448470488 3359 24207032
SGTC_471 1-acyl-paf 4 µM -0.472930268663544 0.359238100365374 no 2199 0.318131464588823 3221 16759367
SGTC_416 estradiol valerate 100 µM -0.473309155102537 0.35910430222057 no 2200 0.317996315726043 3314 13791 A steroid.
SGTC_1024 4507-0395 26 µM -0.474691662622906 0.358616236799779 no 2201 0.317503380694096 3377 4201836
SGTC_391 gliotoxin 8.33 µM -0.4747412830397 0.358598723633531 no 2202 0.317485694471008 3386 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_314 1671-0008 2.74 µM -0.475895275956942 0.358191514140369 no 2203 0.3170744939423 3252 3913060
SGTC_1495 4469-0029 237 µM -0.478268751109239 0.357354493261531 no 2204 0.316229467321462 3298 793680
SGTC_2821 7996764 71.43 µM -0.47832391222954 0.35733504848649 no 2205 0.316209839733238 3450 2987135
SGTC_2278 7948257 134.34 µM -0.480545226782286 0.356552324079576 no 2206 0.315419876032686 3341 1247028
SGTC_3331 9141060 1.957 µM -0.481050104449938 0.356374504473171 no 2207 0.315240444371348 3227 4906567 YPR165W RHO1
SGTC_2673 kobusone 100 µM -0.48154005942404 0.356201970539833 no 2208 0.315066357840651 3314 6710676 An epoxy ketone and protein crosslinker.
SGTC_3203 9113543 49.47 µM -0.482423254016371 0.355891034627115 no 2209 0.314752652595345 3342 17018012
SGTC_1529 apigenin 74 µM -0.482673861858101 0.355802823523484 no 2210 0.314663662574047 3441 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2492 derrusnin 100 µM -0.485656114201526 0.354753698452541 no 2211 0.313605501939674 3286 1715307 Part of coumarin class of compounds.
SGTC_2314 7727897 200 µM -0.486438959483108 0.35447848375652 no 2212 0.313327986818404 3238 900724
SGTC_2277 7947813 106.88 µM -0.487085372085712 0.354251290165707 no 2213 0.313098916103611 3422 1246798
SGTC_587 k089-0003 57 µM -0.490653817456243 0.352998029818727 no 2214 0.311835657781297 3344 9659696
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.491122265483989 0.352833625943164 no 2215 0.311669987246266 3371 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_186 3455-3465 67.277 µM -0.49182489680104 0.352587085942229 no 2216 0.311421567305757 3292 755278
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.492905703299297 0.352207972326879 no 2217 0.311039608625972 3268 390807
SGTC_1014 4130-3005 69.3 µM -0.493870692471747 0.351869607909744 no 2218 0.310698751855348 3236 743608
SGTC_2908 7930301 100 µM -0.494105548968115 0.35178727541386 no 2219 0.31061581960553 3254 2223178
SGTC_3285 9112818 20.8695 µM -0.495377476394031 0.351341502855829 no 2220 0.310166845362514 3322 17017947 YPR165W RHO1
SGTC_735 3076-0345 636 µM -0.495568734323869 0.351274490331062 no 2221 0.310099358186043 3405 2888990
SGTC_254 nsc-64875 3.808 µM -0.49808360208624 0.350393767397943 no 2222 0.309212558920802 3400 56993
SGTC_3337 9144342 33.5465 µM -0.498626109256652 0.350203883116151 no 2223 0.309021404042778 3363 17682949
SGTC_1633 st005664 67.9 µM -0.499026846973051 0.350063643952878 no 2224 0.308880235477662 3240 2063822
SGTC_1320 1313-0481 95.3 µM -0.499120309549662 0.350030939430799 no 2225 0.308847315313769 3430 6813365 YLR208W SEC13
SGTC_1977 st070720 65.3 µM -0.50248929297957 0.348852805647989 no 2226 0.307661691057978 3383 682188
SGTC_2522 biochanin a 4.94 µM -0.504317888357111 0.34821395443846 no 2227 0.307019004476956 3394 5280373 A possible chelator.
SGTC_1245 0418-0076 17.2 µM -0.50617165738541 0.347566747723437 no 2228 0.3063680749531 3396 6790114
SGTC_2754 granisetron 64.02 µM -0.506247194997617 0.347540384666983 no 2229 0.306341563729321 3410 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_519 k048-0011 62.8 µM -0.506311681060278 0.347517879247635 no 2230 0.306318932039022 3338 6836379
SGTC_2269 7935389 174.42 µM -0.506314943488176 0.347516740685535 no 2231 0.306317787094076 3342 97605
SGTC_3102 9121669 49.47 µM -0.508216252408192 0.346853432893513 no 2232 0.305650847155507 3307 41905072
SGTC_2582 agaric acid 100 µM -0.508364446168085 0.346801752360973 no 2233 0.30559889087879 3376 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1757 st041620 31.8375 µM -0.509778565764767 0.346308741119804 no 2234 0.30510330189115 3358 5289815
SGTC_2734 clemastine 41.6 µM -0.511126924061548 0.345838898947803 no 2235 0.304631092051019 3316 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1499 4480-0877 67.3 µM -0.512446321953031 0.345379377856654 no 2236 0.304169339377878 3361 2861909
SGTC_3322 9139058 2.11 µM -0.513822555209836 0.34490030482811 no 2237 0.303688028462605 3421 4908926 YPR165W RHO1
SGTC_2248 tofa 1.1 µM -0.514245267805252 0.344753206518578 no 2238 0.303540261192783 3235 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1061 3448-9325 110 µM -0.514274669421342 0.344742976023432 no 2239 0.303529984490171 3391 723482
SGTC_627 1391-0720 175 µM -0.515740633887248 0.344233027663233 no 2240 0.30301778529435 3341 997839
SGTC_1475 4092-1048 11.7 µM -0.518915053138132 0.343129749810241 no 2241 0.301909990006539 3401 2881759
SGTC_748 act1.228 77.9 µM -0.519483951484381 0.342932168564312 no 2242 0.301711650714529 3360 4421505 YNR035C ARC35
SGTC_1623 st003709 20.3 µM -0.519761587073826 0.342835759922887 no 2243 0.301614877816336 3320 16192618
SGTC_3233 9132340 49.47 µM -0.520539216872973 0.342565783352741 no 2244 0.301343900855354 3313 17682950
SGTC_2488 5268135 45.7 µM -0.523101466179489 0.341676794322725 no 2245 0.30045182263441 3396 1270356 YLR208W SEC13
SGTC_2529 gangaleoidin 93.61 µM -0.523194208663429 0.341644633140851 no 2246 0.300419555593656 3306 4565183
SGTC_1697 st025554 27.742 µM -0.523447023324953 0.341556968065578 no 2247 0.300331604061796 3347 1269519
SGTC_112 phenothiazine 287.218 µM -0.523946204862535 0.341383898825979 no 2248 0.300157978294591 3431 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2471 5466956 24.79 µM -0.525049209509595 0.341001598794433 no 2249 0.299774491287668 3291 724419
SGTC_1398 3558-0053 112 µM -0.525199661930748 0.340949464812767 no 2250 0.299722199960682 3272 4532369
SGTC_591 4299-0174 154 µM -0.526301247386731 0.340567841792244 no 2251 0.299339458239443 3328 5509088
SGTC_2345 9052315 157.45 µM -0.526515687373459 0.340493572157968 no 2252 0.299264977657586 3396 6469265
SGTC_278 4092-0821 23.9 µM -0.527745005024061 0.340067926915289 no 2253 0.298838166031489 3397 877900
SGTC_3012 9080433 71.4286 µM -0.528433817236497 0.33982951807769 no 2254 0.298599135587999 3425 17688859
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.528559300194546 0.339786093329034 no 2255 0.298555600069726 3430 688798
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.528580321234325 0.339778818976448 no 2256 0.298548307235343 3365 6708561
SGTC_2714 st079313 56.9 µM -0.52873765938017 0.339724373842983 no 2257 0.298493724447805 3359 2939799
SGTC_143 4032-1194 15.74 µM -0.529502605994519 0.339459720152306 no 2258 0.298228418564204 3386 1806963
SGTC_2485 5633444 17.78 µM -0.529714887236761 0.339386289818331 no 2259 0.298154812253668 3376 5724239
SGTC_3344 9148862 3.898 µM -0.53102085647594 0.338934675452768 no 2260 0.29770216318968 3463 4905352
SGTC_2711 st079103 59.1 µM -0.531624916833002 0.338725864886023 no 2261 0.297492901918455 3350 54693780
SGTC_2561 acetosyringone 100 µM -0.532478195794767 0.338430989306277 no 2262 0.297197419733907 3282 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3341 9147222 25.867 µM -0.533621579377299 0.338036014864142 no 2263 0.296801687606374 3429 1939759
SGTC_1174 0739-0097 51.1 µM -0.534046990447218 0.337889104837605 no 2264 0.296654511795523 3369 728447
SGTC_1815 st051655 58.2 µM -0.534303363338004 0.337800581808578 no 2265 0.296565832814488 3396 5984156
SGTC_2359 9039622 200 µM -0.534554859603586 0.33771375134698 no 2266 0.296478852452564 3371 6463596
SGTC_2655 perillic acid 100 µM -0.535470572124379 0.337397669597099 no 2267 0.296162250722394 3338 5702197 An apoptosis inducer.
SGTC_2447 5741742 33.78 µM -0.535733864264096 0.337306808759725 no 2268 0.296071247873754 3404 1776504
SGTC_3050 9093513 49.47 µM -0.535992966127722 0.337217403228166 no 2269 0.295981705859766 3425 25236664
SGTC_2735 sertaconazole 140 nM -0.53613797804651 0.337167369515225 no 2270 0.29593159717666 3423 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1040 k898-0338 155 µM -0.536587870348658 0.33701216072812 no 2271 0.295776162261322 3476 20969351
SGTC_330 1488-0319 80.1 µM -0.536984301076403 0.336875418695752 no 2272 0.295639229073369 3393 6846614
SGTC_1216 1165-0504 9.65 µM -0.538235484052159 0.336443985885843 no 2273 0.295207242725542 3448 6304004
SGTC_1840 st055363 71 µM -0.539047593708693 0.33616406946024 no 2274 0.294927007464155 3372 676033
SGTC_1943 st076331 65.2 µM -0.539087829729773 0.336150203344339 no 2275 0.294913126379336 3459 24208415
SGTC_962 1254-0300 21.5 µM -0.541267385317424 0.335399419625838 no 2276 0.294161648571019 3374 7340576
SGTC_167 3672-0051 66.205 µM -0.542556765922125 0.33495558032288 no 2277 0.293717506584989 3375 3237971
SGTC_942 3253-1115 227 µM -0.542628673869099 0.334930834461105 no 2278 0.293692746204282 3483 46497897
SGTC_2180 6301957 200 µM -0.543668294397898 0.334573147372028 no 2279 0.293334877079426 3420 845462
SGTC_2480 5767542 37.17 µM -0.543669379433884 0.334572774137854 no 2280 0.2933345036825 3379 2867358
SGTC_259 usnic acid 108.925 µM -0.544273379199227 0.334365033736385 no 2281 0.293126681497399 3499 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1382 3002-2117 298 µM -0.544378471424025 0.33432889336887 no 2282 0.293090528697204 3494 1497314
SGTC_1052 3253-3998 198 µM -0.544504527186177 0.334285545835737 no 2283 0.293047166954013 3375 5450317
SGTC_1093 fluphenazine 7.97 µM -0.548829228462793 0.332799727248827 no 2284 0.291561324899324 3402 6602611 An atypical antipsychotic.
SGTC_2465 5809242 33.21 µM -0.54983798857762 0.332453528243766 no 2285 0.291215250085334 3414 2731748
SGTC_2085 5307070 144.047 µM -0.549892077065611 0.332434969508367 no 2286 0.291196699393918 3352 2840351
SGTC_262 fenpropimorph 62.5 µM -0.55076306326783 0.332136175033556 no 2287 0.290898053860567 3404 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2872 9044037 25.97 µM -0.550845050458071 0.332108054568957 no 2288 0.290869949298043 3415 6465195
SGTC_1686 st019653 115.5 µM -0.551758710885357 0.331794745769415 no 2289 0.290556839619628 3455 97252
SGTC_401 neomycin 50 µM -0.552045045812284 0.331696581128835 no 2290 0.290458745657006 3403 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1717 st033143 58.0435 µM -0.5522619083959 0.331622241487973 no 2291 0.290384462173524 3501 674616
SGTC_2733 amorolfine 100 µM -0.553013503269948 0.331364649053227 no 2292 0.290127081893265 3419 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1671 st016596 74.5 µM -0.553963351633708 0.331039223742499 no 2293 0.289801963606361 3473 2829167
SGTC_631 k072-0230 41.5 µM -0.553978109185828 0.331034168698365 no 2294 0.289796913675049 3445 5773147
SGTC_1358 1509-0022 2.48 µM -0.554082660726671 0.330998356550718 no 2295 0.289761138050021 3437 3258434
SGTC_1404 3909-7820 48.3 µM -0.559165441199585 0.329259216648042 no 2296 0.288024408100225 3466 23741373
SGTC_586 0957-0265 8.15 µM -0.559296154146711 0.329214539987311 no 2297 0.287979809806573 3401 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1920 st075728 45.7 µM -0.561617516244882 0.328421523364975 no 2298 0.287188321754119 3502 3400306
SGTC_854 0422-0053 192 µM -0.561873104783903 0.328334257127218 no 2299 0.287101239645572 3463 3596728
SGTC_2394 5221648 200 µM -0.561885158440136 0.328330141848276 no 2300 0.287097133127754 3471 788586
SGTC_191 3914-0123 66.505 µM -0.561955570208894 0.328306102747918 no 2301 0.287073145345265 3339 3144412
SGTC_2876 9059903 25.97 µM -0.563403287566987 0.327811998991817 no 2302 0.286580149524688 3451 6916095
SGTC_714 4296-0578 26.1 µM -0.563512239700648 0.327774825972679 no 2303 0.286543063960598 3422 1589775
SGTC_1403 3909-7815 62.9 µM -0.564720636429952 0.32736265157937 no 2304 0.286131897769634 3392 6615483
SGTC_2931 9014674 55.67 µM -0.565166380682956 0.32721066489143 no 2305 0.285980300685206 3373 2996810
SGTC_846 0335-0850 148 µM -0.566934987726648 0.326607900426754 no 2306 0.285379176091054 3455 6819598
SGTC_2251 lansoprazole 556 µM -0.567598833398809 0.326381769795345 no 2307 0.285153699739688 3312 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_486 niguldipine 82 µM -0.568872551755477 0.325948072437374 no 2308 0.284721316959385 3432 1236 A calcium channel blocker.
SGTC_3212 9128307 49.47 µM -0.569931672125894 0.325587624257366 no 2309 0.284362021140922 3267 27243542
SGTC_929 2805-0021 398 µM -0.571059219195977 0.32520406772621 no 2310 0.28397975054577 3462 3098024
SGTC_149 3970-0822 46.1 µM -0.571721909344718 0.324978727441848 no 2311 0.283755194482812 3505 3114250 YBL034C STU1
SGTC_2222 6885208 172.143 µM -0.571943871063142 0.324903266178687 no 2312 0.283680000593709 3444 609514
SGTC_2351 9026858 72.31 µM -0.572812911710584 0.324607883906314 no 2313 0.283385687886129 3395 1409300
SGTC_766 1391-0721 126 µM -0.57371686915324 0.324300750618225 no 2314 0.283079705539598 3496 1020919 YIL115C NUP159
SGTC_138 0850-0259 40.9225 µM -0.575892403576033 0.323562069915411 no 2315 0.282343955254415 3505 6813004
SGTC_2203 7227154 166.4 µM -0.576537581957533 0.323343139552739 no 2316 0.282125937514488 3488 896304
SGTC_75 0159-0059 199.013 µM -0.578283343961165 0.322751051559696 no 2317 0.281536418851554 3611 5377270
SGTC_1605 st000082 49.1 µM -0.579159829333917 0.322453954343915 no 2318 0.281240666597576 3486 1114022
SGTC_1712 st032288 53.4 µM -0.583192867912944 0.321088361543578 no 2319 0.279881735917856 3510 2883011
SGTC_1440 4100-1550 40 µM -0.583361303762079 0.32103138135307 no 2320 0.27982505087698 3481 742806
SGTC_449 xestospongin c 11.1929 µM -0.583447905601455 0.321002086443166 no 2321 0.27979590824684 3471 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_342 k048-0088 23.3 µM -0.583803639342405 0.320881763646121 no 2322 0.279676214726989 3427 6820570
SGTC_3003 9075612 71.4286 µM -0.583893657205383 0.320851319133542 no 2323 0.279645930410445 3485 6501993
SGTC_1460 k062-0059 9.15 µM -0.587287508367832 0.319704381312002 no 2324 0.278505314602656 3424 1373085
SGTC_196 k015-0023 18.111 µM -0.587416497435414 0.319660823895859 no 2325 0.278462008310837 3474 5211998
SGTC_212 3807-4682 38.772 µM -0.587840483923449 0.319517668391261 no 2326 0.278319683844213 3524 3125501 YBL034C STU1
SGTC_3108 9121785 49.47 µM -0.588077864993354 0.319437530392726 no 2327 0.278240014871454 3475 17140271
SGTC_302 1094-0063 18.9 µM -0.588266151690825 0.319373972268417 no 2328 0.278176830682322 3429 5440289
SGTC_1672 st016598 6.51 µM -0.588268716693983 0.319373106461679 no 2329 0.278175969981326 3422 4665860 YNL267W PIK1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.590630301252455 0.318576381267638 no 2330 0.277384078749255 3481 521171
SGTC_395 anisomycin 6.25 µM -0.591600237978059 0.31824939735384 no 2331 0.277059157238322 3462 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1640 st009078 66.4 µM -0.59341679858623 0.317637381609325 no 2332 0.276451124685163 3514 690618
SGTC_1232 0279-0259 161 µM -0.593876028193822 0.31748274178671 no 2333 0.276297516708859 3490 1560000
SGTC_2786 7743617 45.45 µM -0.594384009851753 0.317311722418468 no 2334 0.276127650425243 3405 583674
SGTC_197 4544-0043 41.561 µM -0.594532076037837 0.317261881135127 no 2335 0.276078147554591 3491 896523
SGTC_1192 1488-0095 21.4 µM -0.594681013699764 0.317211749843264 no 2336 0.276028357720092 3488 915875
SGTC_1667 st014849 34.6 µM -0.594788869686945 0.317175448426487 no 2337 0.275992304235238 3523 5348460
SGTC_1416 3966-0321 25.3 µM -0.594829725307386 0.317161697985742 no 2338 0.275978647855183 3485 582530 YLR208W SEC13
SGTC_1760 st045453 10.4495 µM -0.595612241470867 0.316898381681328 no 2339 0.2757171484473 3524 3323419 YIL048W NEO1
SGTC_92 0063-0024 660.874 µM -0.596146011887466 0.316718821381011 no 2340 0.275538844206827 3535 3594437
SGTC_2202 7226349 200 µM -0.597560977025843 0.316243036298719 no 2341 0.275066454384845 3457 844334
SGTC_2534 helenine 20.12 µM -0.597727122099389 0.316187189592718 no 2342 0.275011012596881 3500 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_910 3454-3003 490 µM -0.598213838263981 0.316023612763951 no 2343 0.274848629515795 3505 820824
SGTC_1588 farnesol 29.9 µM -0.598244895192924 0.316013176292779 no 2344 0.27483826959888 3541 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2320 7373003 200 µM -0.598507116836371 0.315925064326964 no 2345 0.274750805828383 3501 5415828
SGTC_2661 dactinomycin 12.96 µM -0.599228399086521 0.315682752333393 no 2346 0.274510293659099 3514 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2110 5483698 200 µM -0.600174942947265 0.315364884755463 no 2347 0.274194825515638 3486 2848765 YHR062C RPP1
SGTC_53 0973-0023 39.979 µM -0.600328821396772 0.315313222324821 no 2348 0.2741435571808 3541 674768
SGTC_1318 1280-3875 124 µM -0.600559082851125 0.31523592216624 no 2349 0.274066848842401 3515 373245
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.602133570611937 0.314707574020181 no 2350 0.273542614938796 3563 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3274 9138298 49.47 µM -0.603245494925768 0.314334675823698 no 2351 0.273172693185043 3493 17015756
SGTC_2751 anetholtrithion 17.25 µM -0.603349226869998 0.314299897627506 no 2352 0.273138195655082 3495 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2352 9027995 87.8 µM -0.60353110967563 0.314238921780831 no 2353 0.273077713159005 3466 2997347
SGTC_2219 9098279 200 µM -0.604059787753962 0.314061712299678 no 2354 0.272901946610344 3513 902349
SGTC_2620 irigenin 100 µM -0.604502174481443 0.313913460060898 no 2355 0.272754911977275 3550 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1130 3454-2858 15.9 µM -0.606537963767906 0.313231615606078 no 2356 0.27207879036559 3448 715628 YIL048W NEO1
SGTC_6 0844-0013 19.835 µM -0.607726795076082 0.312833736675146 no 2357 0.27168434423648 3609 1584900
SGTC_2892 9047358 58.44 µM -0.609378691919711 0.312281240495313 no 2358 0.271136729128104 3470 6466771
SGTC_1370 2001-0092 44.6 µM -0.609447640025845 0.312258189159014 no 2359 0.271113884330856 3626 790957
SGTC_2600 tangeritin 87.95 µM -0.610742815380267 0.311825311400297 no 2360 0.270684928179132 3514 68077 A bioactive flavone.
SGTC_1371 2421-0008 32.7 µM -0.611316429941404 0.311633679040692 no 2361 0.270495058007233 3507 2827552
SGTC_2815 7968870 71.43 µM -0.611396881145105 0.311606806091052 no 2362 0.270468433454585 3538 2977326 YHR190W ERG9
SGTC_1734 st037168 69.4 µM -0.611485228679024 0.311577296702459 no 2363 0.270439197196024 3481 708907
SGTC_2982 9019404 25.97 µM -0.612150468367715 0.31135513563946 no 2364 0.270219104605196 3432 22333232
SGTC_473 2-arachidonoylglycerol 10 µM -0.61247079734208 0.31124818421679 no 2365 0.270113156667338 3444 5282280 An endocannabinoid.
SGTC_719 2810-4230 27.3 µM -0.61429663164008 0.31063887918097 no 2366 0.269509663993688 3509 721079
SGTC_1145 3546-0597 10.2 µM -0.614744268462789 0.310489576020919 no 2367 0.269361809888784 3471 875334
SGTC_211 3455-0679 143.504 µM -0.614927669838669 0.310428414005408 no 2368 0.269301244299796 3559 748649
SGTC_2906 7926292 26.41 µM -0.617240281175036 0.309657637856142 no 2369 0.268538125126297 3543 2966319
SGTC_1777 st045864 34.765 µM -0.617642401548323 0.30952369938417 no 2370 0.268405543826922 3556 4691462
SGTC_414 piperonyl butoxide 100 µM -0.618712235634106 0.309167481674536 no 2371 0.268052973999668 3479 5794 A potent inhibitor of cytochrome P450.
SGTC_208 k072-0098 12.366 µM -0.620204306513301 0.30867097322843 no 2372 0.267561643301572 3554 5948901
SGTC_1204 4049-0315 18.3 µM -0.62176158037198 0.308153140320817 no 2373 0.267049326318137 3596 588402
SGTC_1498 4478-3555 97.6 µM -0.623080209347405 0.307714961184755 no 2374 0.266615907131547 3548 3437919
SGTC_940 3232-1287 54.8 µM -0.624347225899668 0.307294191020445 no 2375 0.266199787718558 3541 1585493 YIL048W NEO1
SGTC_1308 1187-1617 41.4 µM -0.625305921746096 0.306975981154775 no 2376 0.265885147070645 3559 2882570
SGTC_909 3448-9333 149 µM -0.626957875058802 0.306428006700817 no 2377 0.265343424226397 3531 3344074
SGTC_128 0906-2981 13.371 µM -0.627892947367794 0.306118022666358 no 2378 0.265037035702198 3554 6740226
SGTC_66 0109-0187 42.4 µM -0.628341402773147 0.305969405294371 no 2379 0.264890157290264 3589 759417
SGTC_1960 st011366 51.8 µM -0.628572133597045 0.305892953926437 no 2380 0.264814604299289 3570 3972846
SGTC_3198 9112019 49.47 µM -0.62878435104078 0.305822644329554 no 2381 0.26474512320253 3570 45595555
SGTC_1013 4112-3890 241 µM -0.631005062568416 0.305087331761404 no 2382 0.264018607131838 3504 705171
SGTC_2451 5856223 45.7 µM -0.633819680864386 0.304156497055736 no 2383 0.263099253821163 3547 2179896
SGTC_2546 rhodinyl acetate 100 µM -0.633950315264098 0.304113325125388 no 2384 0.263056623790476 3568 6708682
SGTC_2950 9072895 21.46 µM -0.634703652600278 0.303864416227843 no 2385 0.26281085549384 3541 17332245
SGTC_715 0868-0130 184 µM -0.635188100172463 0.303704398758836 no 2386 0.262652871686383 3627 2876258
SGTC_1100 amiodarone 5.07 µM -0.63837302813901 0.302653325691589 no 2387 0.26161544205632 3605 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_906 1165-0455 526 µM -0.640583191574018 0.301924898628927 no 2388 0.260896761504226 3568 3252859
SGTC_3189 9110682 49.47 µM -0.640768163954565 0.301863971048838 no 2389 0.26083665997274 3601 17122418
SGTC_1264 0783-0040 158 µM -0.642893608501855 0.301164273174013 no 2390 0.260146568490988 3539 2855798
SGTC_1964 st076914 61 µM -0.642923844492591 0.301154324737292 no 2391 0.2601367582326 3599 24208661
SGTC_736 0958-0254 92.6 µM -0.64321115335431 0.30105979994924 no 2392 0.260043548571981 3626 6812352
SGTC_774 k060-0086 136 µM -0.643392004803326 0.301000306572645 no 2393 0.25998488499876 3618 5911235
SGTC_444 curcumin 90.4 µM -0.643764822561683 0.300877680172931 no 2394 0.259863974016278 3564 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.644484193580689 0.300641129940743 no 2395 0.259630752081795 3569 97141
SGTC_2360 9040895 200 µM -0.646136155001037 0.300098234720627 no 2396 0.259095591213326 3532 4914414
SGTC_2972 9093619 59.92 µM -0.646597758408237 0.299946614180962 no 2397 0.258946154581332 3567 25236256
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.646773047834198 0.299889046831939 no 2398 0.258889419148616 3622 65057 A dermal irritant. YDR527W RBA50
SGTC_2170 morpholine 200 µM -0.647719220348078 0.29957839774814 no 2399 0.25858328525108 3590 121171 Reacts with secondary amines.
SGTC_2755 lomerizine 42.69 µM -0.647860758749106 0.299531940143909 no 2400 0.258537506657322 3594 3949 A calcium channel blocker.
SGTC_2046 4110841 106 µM -0.64818012329043 0.299427126092555 no 2401 0.258434228135775 3601 44119630 YMR134W ERG29
SGTC_599 1935-0052 86.5 µM -0.650412111214356 0.298695062101755 no 2402 0.257713028103666 3567 9557311
SGTC_1991 st073000 8.92 µM -0.650762860778142 0.298580094673288 no 2403 0.257599788959706 3659 4301969 YIL048W NEO1
SGTC_1798 st045719 60.953 µM -0.651421368067306 0.298364305906861 no 2404 0.257387260357883 3551 3980186
SGTC_2793 7325131 81.82 µM -0.65274477740822 0.297930847680122 no 2405 0.256960415004401 3565 4176441
SGTC_1819 st053448 58.6 µM -0.653349013011236 0.297733037001511 no 2406 0.256765650622996 3555 2857616
SGTC_2929 9013348 24.6 µM -0.653703329448206 0.297617071091869 no 2407 0.256651478902045 3589 2995952
SGTC_1361 1608-0041 5.61 µM -0.653903801673896 0.297551466717923 no 2408 0.256586892258924 3593 X1361
SGTC_2742 clothiapine 36.27 µM -0.653906935345564 0.297550441278806 no 2409 0.25658588274321 3555 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2371 9071574 200 µM -0.654595279130672 0.297325231952269 no 2410 0.256364182192504 3577 45596039
SGTC_393 acivicin 6.25 µM -0.655936046273042 0.296886789323946 no 2411 0.255932637058432 3530 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2446 5162541 200 µM -0.656009232019851 0.296862865459848 no 2412 0.255909092090981 3572 1549321
SGTC_1331 1472-0049 76.2 µM -0.659082160776433 0.295859145697709 no 2413 0.254921505233131 3589 24051409
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.661636024859762 0.295026157461497 no 2414 0.254102257053314 3611 6708739 YPR165W RHO1
SGTC_1119 parthenolide 318.541 nM -0.661979421645428 0.294914234936095 no 2415 0.253992205015953 3668 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1674 st016616 23.6 µM -0.662515912459955 0.294739416892891 no 2416 0.253820320142103 3599 625830
SGTC_433 pimozide 108 µM -0.662883819854664 0.294619560173974 no 2417 0.253702482569952 3563 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3252 9135871 49.47 µM -0.662938068819581 0.294601888870943 no 2418 0.25368510952405 3641 17682838
SGTC_740 k014-0057 261 µM -0.662965869033505 0.294592833293112 no 2419 0.253676206842528 3610 4012779
SGTC_1063 disulfiram 1.84 µM -0.6642184533768 0.294184952663792 no 2420 0.25327525219493 3625 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_681 1642-0006 26.6 µM -0.667479480972937 0.293124285939395 no 2421 0.252232956003394 3635 4446530
SGTC_2732 terfenadine 20 µM -0.669484540454284 0.292473011292331 no 2422 0.251593219562378 3618 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1547 harmine 94.2 µM -0.671848422642225 0.291706050506227 no 2423 0.250840099157434 3670 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3248 9135562 49.47 µM -0.672162270650433 0.291604293152922 no 2424 0.250740198657497 3661 17650701
SGTC_2364 9055074 200 µM -0.672869380815461 0.291375091066593 no 2425 0.25051519668662 3614 6470630
SGTC_1736 st036774 51 µM -0.673264134948977 0.291247172371746 no 2426 0.250389632740799 3661 1272247
SGTC_3207 9114163 49.47 µM -0.673612937390646 0.291134165981942 no 2427 0.250278712939957 3679 849233
SGTC_1691 st019933 84.6 µM -0.676328431740047 0.290255090461513 no 2428 0.249416072569845 3620 6176082
SGTC_666 0272-0154 136 µM -0.676682892744246 0.290140434099776 no 2429 0.249303586448739 3664 6870312
SGTC_2420 aureobasidin a 50 nM -0.676825411815827 0.29009433989677 no 2430 0.249258366460741 3697 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2968 9090663 33.37 µM -0.677569157504956 0.28985384979869 no 2431 0.249022453592648 3609 25236811
SGTC_2966 9084041 48.03 µM -0.678173374185079 0.289658545264949 no 2432 0.248830886211298 3571 17741380
SGTC_2687 chenodiol 100 µM -0.678739559291511 0.289475589980351 no 2433 0.248651447996959 3647 5702181 A cholesterol synthesis inhibitor.
SGTC_2814 7977482 42.97 µM -0.678778629712972 0.289462966888698 no 2434 0.248639068146241 3681 6456762
SGTC_1935 st074532 41.6 µM -0.679632960810799 0.28918700944877 no 2435 0.248368446957555 3702 2829742
SGTC_2236 dapsone 200 µM -0.684159809945771 0.287726860170548 no 2436 0.246937128794446 3669 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2033 5192550 145 µM -0.684547123675256 0.287602092865653 no 2437 0.246814871638153 3639 182073
SGTC_3121 9125696 49.47 µM -0.686304579781319 0.287036276299934 no 2438 0.246260530789623 3704 1235365
SGTC_1885 st057546 99.9 µM -0.687739206123399 0.286574786617918 no 2439 0.245808512977543 3706 702008
SGTC_2685 mycophenolic acid 18.85 µM -0.688315398681054 0.286389536479615 no 2440 0.245627093377354 3628 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2779 methotrexate 400 µM -0.689208174965791 0.286102614661758 no 2441 0.245346136533113 3719 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1459 k035-0031 35.7 µM -0.689273298122495 0.286081690626783 no 2442 0.245325649026519 3552 3877128 YMR208W ERG12
SGTC_1526 st051518 75 µM -0.690042286510259 0.285834670073781 no 2443 0.245083797650797 3642 673993
SGTC_1913 st060213 96.1 µM -0.691262852181722 0.285442798668167 no 2444 0.244700186027177 3680 688959
SGTC_131 0141-0277 33.849 µM -0.691297547217626 0.285431663316963 no 2445 0.244689286450748 3623 1547771
SGTC_707 0865-0008 204 µM -0.693358306476741 0.284770635161485 no 2446 0.244042360290405 3662 723043
SGTC_2776 terbinafine 19.92 µM -0.694390470990894 0.284439823372505 no 2447 0.24371868398585 3678 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3224 9130643 49.47 µM -0.695064099490714 0.284224022499491 no 2448 0.243507565983853 3697 17644395
SGTC_88 0180-0332 8.668 µM -0.696471822491309 0.283773302993932 no 2449 0.243066698790489 3726 3101745
SGTC_3267 9137951 49.47 µM -0.698168169063963 0.283230628171299 no 2450 0.242536015204962 3668 16643986
SGTC_3025 9087895 49.47 µM -0.698457982431761 0.283137964372176 no 2451 0.242445413045707 3680 17173641
SGTC_1669 st015249 58.4 µM -0.70203698232567 0.281994829575087 no 2452 0.241328050175629 3744 722793
SGTC_2514 salinomycin 42.74 µM -0.702128842209981 0.281965518754246 no 2453 0.241299408418907 3732 23682228 A polyether potassium ionophore.
SGTC_2607 solasodine 47.35 µM -0.702244484251106 0.2819286215658 no 2454 0.24126335405243 3707 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2564 betulinic acid 100 µM -0.703016964910929 0.281682210637443 no 2455 0.241022588545562 3707 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2614 arthonioic acid 13.39 µM -0.70346340300804 0.281539850258191 no 2456 0.240883503047939 3645 6710684
SGTC_1442 4112-3290 3 µM -0.704068040377153 0.281347098573732 no 2457 0.240695201011208 3672 704353
SGTC_2090 5301565 104.445 µM -0.705102451030667 0.281017487707501 no 2458 0.240373240665902 3710 2056344
SGTC_1806 st050005 60.3 µM -0.705901048206346 0.280763145571868 no 2459 0.240124837833613 3685 5194765
SGTC_1949 st076024 69.1 µM -0.705951008604853 0.280747237577944 no 2460 0.240109302355021 3665 2921930
SGTC_428 3448-4153 16.5 µM -0.707123992985888 0.280373870507119 no 2461 0.239744713479166 3664 3834874
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.709662465418592 0.279566685584605 no 2462 0.238956736697843 3697 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_320 4092-0846 5.34 µM -0.710902185517183 0.27917288912668 no 2463 0.238572425801733 3674 1359356
SGTC_1773 st048542 73.5835 µM -0.71208408048918 0.278797712038454 no 2464 0.238206355814621 3650 3237138
SGTC_14 0354-0009 295 µM -0.712157762304535 0.278774330839031 no 2465 0.238183544437835 3730 1713507
SGTC_2080 5212524 12.4 µM -0.713509870563475 0.278345440469984 no 2466 0.237765153718585 3667 260183
SGTC_2957 9076800 11.52 µM -0.714048278990125 0.278174746244309 no 2467 0.237598663159343 3659 16459615
SGTC_524 r073-0010 27.8 µM -0.714501931216744 0.278030962324912 no 2468 0.237458431202867 3643 2772106
SGTC_2386 9075165 157.42 µM -0.714845304857571 0.277922155038432 no 2469 0.237352318532206 3679 16452277
SGTC_3042 9091578 49.47 µM -0.714993116083158 0.277875323427062 no 2470 0.237306648483923 3651 25236497
SGTC_34 0469-0683 81.75 µM -0.715755716703205 0.277633766901121 no 2471 0.237071100266441 3689 3690923
SGTC_2983 9022671 12.99 µM -0.717760983823141 0.276999081181149 no 2472 0.236452337048022 3695 6405161
SGTC_893 0958-0369 48.9 µM -0.718171459802824 0.276869249340127 no 2473 0.236325786587256 3725 6819948
SGTC_2027 5150920 200 µM -0.718894368560064 0.276640668798574 no 2474 0.236103003254791 3680 786715
SGTC_1507 4075-3230 155 µM -0.720789250800613 0.276041954734337 no 2475 0.235519594973258 3632 659771
SGTC_2722 naftopidil 47.16 µM -0.721527694096849 0.275808805843325 no 2476 0.235292453966137 3666 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1962 st076595 64.5 µM -0.721804546253532 0.275721420187544 no 2477 0.23520732697933 3732 279619
SGTC_2877 9040724 71.43 µM -0.723844019265871 0.275078100324407 no 2478 0.234580750626878 3691 6463895
SGTC_1888 azatryptophan 97.5 µM -0.724746573419098 0.274793639899264 no 2479 0.23430375871563 3706 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3051 9093778 49.47 µM -0.725768835138989 0.274471626157034 no 2480 0.233990247573249 3731 17217378
SGTC_32 0928-0142 34.1 µM -0.726544065749381 0.274227551743482 no 2481 0.233752651892992 3675 2244242
SGTC_3166 9102297 49.47 µM -0.72669442715719 0.27418022421523 no 2482 0.233706584034999 3690 25237072
SGTC_1641 st009299 47.1 µM -0.72719254339692 0.274023466731109 no 2483 0.233554006711112 3652 4046054
SGTC_3276 9139060 49.47 µM -0.727677352005417 0.273870939709213 no 2484 0.233405558692786 3791 4870619
SGTC_333 3486-0131 40.1 µM -0.727853476574486 0.273815539051484 no 2485 0.233351642452284 3784 6744690
SGTC_509 pifithrin 175 µM -0.728937855621006 0.273474565615676 no 2486 0.233019838557715 3753 4817 A p53 inhibitor.
SGTC_2069 5228469 200 µM -0.729232502943845 0.273381952690559 no 2487 0.232929726138691 3691 2835210
SGTC_1490 4089-0339 670 nM -0.731734429248039 0.272596178876592 no 2488 0.23216533888763 3678 742542
SGTC_505 gw-5074 63.9 µM -0.731847965370386 0.272560547476955 no 2489 0.232130684535055 3764 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2279 7948423 32.93 µM -0.733273542293912 0.272113351050905 no 2490 0.231695804301545 3708 1247112
SGTC_3239 9133757 49.47 µM -0.73378548989672 0.271952844686008 no 2491 0.231539742675531 3721 17036923
SGTC_1789 tunicamycin 25 nM -0.734210045709097 0.271819773217928 no 2492 0.231410365940242 3705 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2147 5545932 89.7195 µM -0.734547144105396 0.271714137214903 no 2493 0.231307669200686 3743 797404
SGTC_2427 5545055 42.75 µM -0.734805928754138 0.271633056137205 no 2494 0.231228847929234 3723 5372858
SGTC_1852 st056254 31.4 µM -0.735534988504703 0.271404695672722 no 2495 0.231006869692128 3688 442583
SGTC_3264 9137442 49.47 µM -0.736730260148784 0.271030512605104 no 2496 0.23064320052422 3738 17015726
SGTC_423 5-fluorouracil 457 µM -0.737758889905247 0.270708703387791 no 2497 0.230330489497436 3705 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2136 5328288 199.296 µM -0.738076631396757 0.27060933580529 no 2498 0.230233941691253 3741 262395
SGTC_1658 st012944 20 µM -0.738315276038063 0.270534716233588 no 2499 0.230161442861407 3670 24207260
SGTC_3289 9119912 71.43 µM -0.739782676194853 0.2700761145903 no 2500 0.22971593617986 3743 17014829
SGTC_1699 st031318 29.054 µM -0.74075483257884 0.269772504155817 no 2501 0.229421053018402 3807 5340658
SGTC_2887 9044784 58.44 µM -0.742220198402256 0.269315184582147 no 2502 0.228976966343201 3739 6465546
SGTC_479 n-linoleoylglycine 10 µM -0.743068095855032 0.269050745666379 no 2503 0.228720227090514 3770 6433346 An anti-infammatory.
SGTC_1121 fusaric acid 630.51 nM -0.744436914490184 0.268624119081737 no 2504 0.228306096701251 3765 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2865 9030313 51.95 µM -0.744893075040435 0.268482020791241 no 2505 0.228168180906336 3692 42562754
SGTC_3256 9138902 49.47 µM -0.746864614824283 0.267868302609106 no 2506 0.227572643678632 3770 17228773
SGTC_2962 9082311 13.18 µM -0.747677499786183 0.267615466551526 no 2507 0.227327352978248 3748 16459453
SGTC_472 calcifediol 10 µM -0.748244256027596 0.267439256460681 no 2508 0.227156420600688 3776 5283731 A vitamin D metabolite.
SGTC_1391 3442-0225 151 µM -0.74871248716546 0.267293722949613 no 2509 0.227015257835912 3712 5227075
SGTC_1567 st069303 68.4 µM -0.748960085678211 0.267216781641345 no 2510 0.226940631601891 3821 5581319
SGTC_863 0466-0191 129 µM -0.749087477728852 0.267177198880925 no 2511 0.226902241007262 3757 765160 YPR165W RHO1
SGTC_2439 5492030 7.2 µM -0.749645932817595 0.267003712828825 no 2512 0.226733989414887 3758 5722370
SGTC_1758 st042942 75.2445 µM -0.749697915916754 0.266987566989623 no 2513 0.226718331506474 3701 669317
SGTC_2387 9077560 195.08 µM -0.749949322804997 0.266909487508757 no 2514 0.226642613467253 3741 5303272
SGTC_824 1304-0008 100 µM -0.752879777671825 0.266000227307614 no 2515 0.225761080559687 3775 768245
SGTC_2167 5876490 200 µM -0.753038954234987 0.265950883042819 no 2516 0.225713253020405 3907 686534
SGTC_108 0509-0257 621.132 µM -0.753286519124482 0.26587414787407 no 2517 0.2256388789668 3736 536624
SGTC_1940 st075990 51.1 µM -0.754814250890009 0.265400860795766 no 2518 0.225180220963509 3834 1084979
SGTC_2414 st077232 92.9 µM -0.755064534466823 0.265323364415295 no 2519 0.225105130820047 3740 729801
SGTC_3350 9150499 3.57 µM -0.756559359081991 0.264860754729293 no 2520 0.224656948666684 3735 4910996 YPR165W RHO1
SGTC_3005 9076496 71.4286 µM -0.756672548543801 0.264825742213792 no 2521 0.22462303253766 3782 21368410
SGTC_2813 7971799 71.43 µM -0.760929404647391 0.263510693649431 no 2522 0.223349617153848 3841 2234054
SGTC_3187 9109394 49.47 µM -0.763940939140804 0.262582372899267 no 2523 0.222451219637204 3743 17098090
SGTC_3006 9075424 71.4286 µM -0.764624035983643 0.262372037955522 no 2524 0.222247726101616 3769 7465181
SGTC_1046 2001-0062 216 µM -0.765065798190094 0.262236059231729 no 2525 0.222116182373088 3693 739778
SGTC_3299 9121982 43.1275 µM -0.765221508321794 0.262188138738597 no 2526 0.22206982709269 3839 17594604 YPL160W CDC60
SGTC_431 k089-0097 107 µM -0.765246670571894 0.262180395364123 no 2527 0.222062336748719 3721 5499420
SGTC_111 0083-0039 52.457 µM -0.765767407373671 0.262020171296871 no 2528 0.221907355259726 3682 759313
SGTC_2425 5628681 7.85 µM -0.765848130366602 0.26199533835663 no 2529 0.221883336044353 3838 5714958
SGTC_2798 7813637 45.45 µM -0.766643343027832 0.261750770350472 no 2530 0.221646799014833 3774 956368
SGTC_2618 avocadyne 43.43 µM -0.768226728652047 0.261264148428722 no 2531 0.221176248277448 3718 3015189
SGTC_2979 9012552 45.46 µM -0.768326136447691 0.261233612943571 no 2532 0.221146725335159 3825 17100905
SGTC_271 rotenone 740 µM -0.768441245825775 0.261198256632559 no 2533 0.221112542025329 3792 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2122 5258151 111.688 µM -0.768769169597758 0.261097547002338 no 2534 0.221015177136517 3792 2173356
SGTC_2458 5808907 16.39 µM -0.769061285260149 0.261007851317962 no 2535 0.220928464815919 3828 2731747
SGTC_2302 7771753 200 µM -0.771004716499352 0.260411513891192 no 2536 0.220352067987738 3793 2203047
SGTC_51 1013-0126 23.419 µM -0.771094638130757 0.260383938640492 no 2537 0.220325419265777 3836 1627850
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.772243750290851 0.260031685867141 no 2538 0.219985036876366 3786 641818 YHR062C RPP1
SGTC_859 0439-0102 54.6 µM -0.772957228755064 0.259813097449393 no 2539 0.219773846928958 3771 610143
SGTC_3056 9094900 49.47 µM -0.773158523867099 0.259751443812182 no 2540 0.219714284542424 3772 25236784
SGTC_1307 1187-1599 12.2 µM -0.774682626415824 0.259284879455763 no 2541 0.219263609784009 3804 1538471
SGTC_3035 9091303 49.47 µM -0.775684295870776 0.258978480413028 no 2542 0.218967707258955 3828 25237002
SGTC_1765 st044815 90.4 µM -0.777728768277416 0.258353681777915 no 2543 0.21836446436638 3832 645695
SGTC_2781 5567276 71.43 µM -0.778038624619726 0.258259056691909 no 2544 0.218273121634084 3835 2853274
SGTC_1439 4092-1168 46 µM -0.778183005080187 0.258214971384117 no 2545 0.218230567153619 3796 2886240
SGTC_745 0469-0705 296 µM -0.779149837751109 0.257919858061841 no 2546 0.217945727559364 3863 3486736
SGTC_2301 7769476 200 µM -0.780207052150866 0.257597357278414 no 2547 0.217634506017117 3850 977820
SGTC_1285 0929-0069 65.5 µM -0.780687425520001 0.257450889727398 no 2548 0.217493179043066 3815 1206237
SGTC_2556 citropten 84.59 µM -0.782476510364538 0.256905772267431 no 2549 0.216967292371277 3845 2775 A potential DNA crosslinker.
SGTC_2142 5622915 118.518 µM -0.782642978718646 0.256855081471499 no 2550 0.216918397778392 3820 5322196
SGTC_2924 9010168 62.78 µM -0.783530604077317 0.256584881144934 no 2551 0.216657794628095 3899 2993929
SGTC_1519 esterone 74 µM -0.784587488963541 0.256263350031442 no 2552 0.21634773388354 3807 698 A steroid.
SGTC_2832 7992762 51.95 µM -0.784930492435131 0.256159044863728 no 2553 0.216247161400025 3775 2985177
SGTC_1347 1493-0251 600 nM -0.785466591992415 0.255996064760153 no 2554 0.216090025195832 3843 3986378
SGTC_159 3970-0959 50 µM -0.785559265281503 0.255967896556253 no 2555 0.216062868423039 3887 6615653
SGTC_2242 6630449 61.2675 µM -0.786462709369349 0.255693377938222 no 2556 0.215798228785589 3885 691249 YDR170C SEC7
SGTC_2725 haloperidol 53.21 µM -0.787278997646227 0.255445474566558 no 2557 0.215559280736796 3777 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1421 4029-0249 71.4 µM -0.788039187911546 0.255214720920105 no 2558 0.215336892029289 3879 2894095
SGTC_1973 st070275 50.2 µM -0.789688419039905 0.254714476366341 no 2559 0.214854878178724 3718 17118334
SGTC_2837 9008476 45.46 µM -0.792047201085351 0.253999904214597 no 2560 0.214166577265739 3795 2992805
SGTC_1240 0356-0016 42.1 µM -0.793211746227283 0.253647503794415 no 2561 0.213827232513734 3827 4305613
SGTC_2160 5660466 132.927 µM -0.793916940646779 0.253434231375156 no 2562 0.213621893402691 3754 2859134
SGTC_936 3005-4620 401 µM -0.794022300497234 0.253402375419024 no 2563 0.213591224499205 3820 777207
SGTC_3349 9149703 23.001 µM -0.794653474290049 0.253211581670583 no 2564 0.213407551615397 3801 4910494
SGTC_352 k048-0007 5.11 µM -0.796130812001767 0.252765301605011 no 2565 0.212978003394986 3854 6811911
SGTC_1015 4130-4525 82 µM -0.796255261909072 0.252727726203086 no 2566 0.212941841603612 3834 1363237
SGTC_825 1988-2224 89.6 µM -0.796664825818747 0.252604086549271 no 2567 0.212822858663527 3813 1180859
SGTC_2597 laccaic acid a 100 µM -0.797283698986486 0.25241732082703 no 2568 0.212643142663628 3851 5491415 A textile dye.
SGTC_279 1273-0055 2.93 µM -0.798797386471417 0.25196082176628 no 2569 0.212203953123543 3848 2847562
SGTC_1904 st060225 78 µM -0.799215600542715 0.251834773297524 no 2570 0.212082703768624 3781 66595
SGTC_1431 4049-0260 9.09 µM -0.799950377784798 0.251613394285647 no 2571 0.211869774005298 3807 3854841
SGTC_1321 1326-2144 215 µM -0.801040063776759 0.251285275161021 no 2572 0.211554226259991 3845 3513030
SGTC_1238 0333-0287 48.8 µM -0.804049276577129 0.250380337003473 no 2573 0.210684258499451 3836 7226
SGTC_2817 7995342 71.43 µM -0.805153262272564 0.250048777251767 no 2574 0.210365621629005 3836 18879975
SGTC_1469 k284-2957 126 µM -0.805480354710793 0.249950586413115 no 2575 0.210271269229742 3829 23884841
SGTC_1031 k035-0009 16 µM -0.806003479399415 0.2497935906219 no 2576 0.210120421443486 3922 5180959
SGTC_1909 st060837 51.5 µM -0.806393937583532 0.249676443720518 no 2577 0.210007870700761 3863 678937
SGTC_851 0394-0702 453 µM -0.806468093139019 0.24965419855735 no 2578 0.209986499142956 3806 762646
SGTC_2904 7225135 42.03 µM -0.806550724997805 0.249629411915173 no 2579 0.209962686228469 3907 4446116
SGTC_917 harmaline 728.087 nM -0.807051286120073 0.249479289187418 no 2580 0.209818468055135 3859 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3156 9099931 49.47 µM -0.807426694034286 0.249366732508982 no 2581 0.209710346373229 3874 18111053
SGTC_673 1082-0474 110 µM -0.807542010167866 0.249332163269332 no 2582 0.209677140614332 3856 3098046
SGTC_996 3970-0799 1.8 µM -0.808838519403926 0.248943673732884 no 2583 0.209304018250412 3884 6615648 YGL040C HEM2
SGTC_1118 chelidonine 707.474 nM -0.809655009405159 0.248699183877213 no 2584 0.209069241289536 3818 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_608 k048-0125 159 µM -0.810071623687858 0.248574482138772 no 2585 0.208949506048476 3874 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3038 9091290 49.47 µM -0.810621514395185 0.248409938873773 no 2586 0.208791528926326 3835 25236843
SGTC_1910 st062352 60.4 µM -0.811067076270758 0.248276656411967 no 2587 0.208663575881955 3798 2245730
SGTC_2406 ethylparaben 405.7 µM -0.812551443610334 0.247832907722716 no 2588 0.208237640254865 3902 8434 A possible steroid mimic.
SGTC_100 0086-0128 49.5915 µM -0.813499284046645 0.247549774344257 no 2589 0.207965928302922 3903 93297
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.813836352079807 0.247449129012986 no 2590 0.207869353429786 3856 2724 A muscle relaxant with antifungal properties.
SGTC_1235 benzylparaben 21.5 µM -0.814436993027777 0.247269837513276 no 2591 0.207697326758124 3859 7180
SGTC_2512 diallyl trisulfide 49.23 µM -0.814780216635488 0.247167416358377 no 2592 0.207599063515377 3874 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2274 7947094 46.08 µM -0.814823630283645 0.247154462933777 no 2593 0.207586636357304 3818 2971028
SGTC_2001 4023502 57.655 µM -0.818626611406825 0.246021169446442 no 2594 0.206499739658952 3884 108941 YCR052W RSC6
SGTC_3073 9114972 49.47 µM -0.818637241610116 0.246018005543647 no 2595 0.206496706266339 3809 41905075
SGTC_986 1493-0483 84 µM -0.818682083522277 0.246004659336312 no 2596 0.206483910646828 3783 40079
SGTC_753 1322-0200 289 µM -0.818955298650068 0.245923351266383 no 2597 0.206405958983 3900 5403907
SGTC_1089 terbinafine 2.25 µM -0.819655815929487 0.245714945160084 no 2598 0.206206172403417 3862 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1205 4161-2785 76 µM -0.820467311436703 0.245473641285868 no 2599 0.205974878358158 3966 3498106
SGTC_2389 9091542 195.52 µM -0.822045551977622 0.245004705250935 no 2600 0.205525486027652 3862 3626624 YOL127W RPL25
SGTC_189 3970-0742 2.116 µM -0.825090047697961 0.244101470144786 no 2601 0.204660234767065 3831 2891807
SGTC_3023 9089636 49.47 µM -0.825151581941913 0.244083232817725 no 2602 0.204642768994379 3947 17249241
SGTC_2806 7952793 58.44 µM -0.825284826361072 0.244043744771469 no 2603 0.204604952169583 3904 2972490
SGTC_2245 6637752 200 µM -0.825491093337224 0.243982622704706 no 2604 0.204546418616046 3948 681890
SGTC_456 gingerol 170 µM -0.825655276873057 0.243933976918074 no 2605 0.204499834443083 3874 442793 A herb.
SGTC_2297 7971671 152.32 µM -0.82721176083294 0.243473067813224 no 2606 0.204058523400489 3848 909016
SGTC_2621 lithochol-11-enic acid 100 µM -0.828343028644688 0.243138370016753 no 2607 0.203738130523774 3810 6708711
SGTC_2794 7785382 27.27 µM -0.830448329132223 0.242516157013142 no 2608 0.203142675238409 3803 2205081
SGTC_3173 9105693 49.47 µM -0.832115366311026 0.242024083417839 no 2609 0.202671914555261 3887 17096658
SGTC_2835 9006588 71.43 µM -0.832299009748324 0.241969908947462 no 2610 0.20262009471455 3966 2345538
SGTC_1558 st069300 45.6 µM -0.833464953357118 0.241626111262852 no 2611 0.202291277750843 3799 24208000
SGTC_2052 5265182 7.135 µM -0.833897935579786 0.241498506881861 no 2612 0.202169250332506 3897 1239884
SGTC_1341 1486-1360 280 µM -0.835216486157561 0.241110141793158 no 2613 0.201797914470745 3848 3976547
SGTC_2952 9073731 13.78 µM -0.835772534190034 0.240946465587441 no 2614 0.201641440354562 3941 16457353
SGTC_2803 7707263 71.43 µM -0.836033776983041 0.240869588013635 no 2615 0.201567950700187 3858 2199229
SGTC_805 3852-0218 479 µM -0.837029808025578 0.240576602105322 no 2616 0.201287906581148 3816 6615355
SGTC_2368 9071271 200 µM -0.837512580339629 0.240434662836549 no 2617 0.201152254269447 3894 27209959
SGTC_3247 9135149 49.47 µM -0.839086876624961 0.239972123043304 no 2618 0.200710279911296 3860 8934436 YOR116C RPO31
SGTC_997 3996-0078 137 µM -0.840022362970161 0.239697500301906 no 2619 0.200447923999057 3921 735687
SGTC_1143 3454-2408 5.08 µM -0.840524963242352 0.239550027084442 no 2620 0.200307055515283 3815 X1143
SGTC_1350 1495-0454 146 µM -0.840764771822388 0.2394796797931 no 2621 0.200239863085351 3917 1069057
SGTC_1893 st059353 36.1 µM -0.841198146844272 0.239352578852042 no 2622 0.200118469260458 3927 3112488
SGTC_2719 novobiocin 32.65 µM -0.84144604996523 0.239279889986211 no 2623 0.200049048354693 3879 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1959 st077091 55.8 µM -0.842374155748192 0.239007862751769 no 2624 0.199789277253754 3891 821356 YKL052C ASK1
SGTC_1033 k072-0102 21.3 µM -0.842854452491326 0.238867154487694 no 2625 0.199654924859086 3853 5965931
SGTC_1360 1598-0022 39.8 µM -0.843700113785261 0.238619518769987 no 2626 0.199418501973942 3955 761525
SGTC_2332 7982454 138.89 µM -0.843747370227125 0.238605684772079 no 2627 0.199405295388916 3850 2981748
SGTC_3253 9135987 49.47 µM -0.844441146971387 0.23840263694308 no 2628 0.199211468755579 3859 4182430
SGTC_2805 7950783 58.44 µM -0.844807326510062 0.238295505238779 no 2629 0.19910921166168 3927 1178958 YDL195W SEC31
SGTC_2653 dihydrofissinolide 100 µM -0.845734495482863 0.238024365018184 no 2630 0.198850437471658 3935 6857746
SGTC_1481 3346-2004 36 µM -0.845767505855612 0.238014714621585 no 2631 0.198841227968278 3924 2770522
SGTC_3043 9092303 49.47 µM -0.846363686794222 0.237840461401134 no 2632 0.198674944798814 3901 25236084
SGTC_2455 5377712 9.75 µM -0.846407352992147 0.237827701288519 no 2633 0.198662768984601 3899 2243908
SGTC_603 3794-0023 45.9 µM -0.84645226110203 0.237814578656684 no 2634 0.198650247346985 3876 3802260
SGTC_1709 st033179 39.1045 µM -0.846795409678044 0.237714320070101 no 2635 0.198554583636508 3863 573381
SGTC_2355 9061122 103.12 µM -0.85147103691279 0.236350543275659 no 2636 0.197253872791563 3936 5302957
SGTC_2372 9071633 200 µM -0.851601797933216 0.236312465203665 no 2637 0.197217570686978 3964 21321366
SGTC_2731 amoxapine 43.43 µM -0.851935166297964 0.236215402440752 no 2638 0.197125038664737 3982 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_579 4491-1009 110 µM -0.854043693548775 0.235601997428943 no 2639 0.196540390095764 4036 1271041
SGTC_1606 st000094 49.2 µM -0.855028456547101 0.235315815092514 no 2640 0.196267697127065 3893 1242210
SGTC_2186 6124449 200 µM -0.855239836239614 0.235254410988828 no 2641 0.196209193411331 3905 3834182 YLR033W RSC58
SGTC_835 0312-0010 67.2 µM -0.858685831837423 0.234254625627139 no 2642 0.195256934631393 3876 1626196
SGTC_1470 k295-0292 231 µM -0.862230057872365 0.233228798987773 no 2643 0.194280466140129 3989 5045612
SGTC_2404 5161160 200 µM -0.862271098708921 0.233216934913049 no 2644 0.194269176437692 3886 2831543
SGTC_3328 9140624 29.0385 µM -0.862670862852085 0.233101388719568 no 2645 0.19415922837468 3958 4904392
SGTC_1366 1683-0113 21.9 µM -0.863365114229878 0.232900800690557 no 2646 0.193968376891966 3915 708623
SGTC_2696 st077691 74.316 µM -0.8642165017204 0.232654942731813 no 2647 0.193734484407984 3957 757133
SGTC_2015 5119600 184 µM -0.864840096345021 0.232474956835288 no 2648 0.193563280140546 3965 2828786
SGTC_1746 st038117 42 µM -0.86581914026765 0.232192535156191 no 2649 0.19329467557301 3997 2898218
SGTC_583 1488-1091 88.9 µM -0.865953200414337 0.232153878121341 no 2650 0.193257913356527 4038 4303273
SGTC_2490 carminic acid 95.39 µM -0.867065714591065 0.231833216332303 no 2651 0.192953002368627 3827 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_236 1509-0011 5.31 µM -0.867403171835488 0.231735999266606 no 2652 0.192860572286023 3986 3107280
SGTC_1768 st044301 37.178 µM -0.867667715187017 0.231659803635374 no 2653 0.192788132351366 3929 3931349
SGTC_2848 9016370 25.97 µM -0.867911376984448 0.231589634809654 no 2654 0.192721425123842 3888 7894410
SGTC_849 0386-0493 241 µM -0.869078308540906 0.231253750437668 no 2655 0.19240215012769 3880 726119
SGTC_794 k038-0031 316 µM -0.869867698777476 0.231026690059247 no 2656 0.192186354756426 3917 6624242
SGTC_983 1491-0821 12.2 µM -0.869947008799474 0.231003884188839 no 2657 0.192164681987894 3946 46495113
SGTC_3206 9114350 49.47 µM -0.870942165633328 0.230717830246811 no 2658 0.191892866111029 3845 17087243
SGTC_646 4092-0839 27.3 µM -0.871164979969964 0.230653810259404 no 2659 0.191832039148307 3978 877796
SGTC_3296 9122258 64.045 µM -0.871689706817364 0.230503082668643 no 2660 0.191688838541334 3951 4730474
SGTC_2478 5763493 32.33 µM -0.873902737709906 0.229867996458009 no 2661 0.191085611832121 3874 1365576 YLR208W SEC13
SGTC_499 genistein 192 µM -0.8748958290303 0.229583322065896 no 2662 0.190815294377092 3952 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.875115247384508 0.229520451392713 no 2663 0.190755600806394 3933 689007
SGTC_768 0384-0033 77.3 µM -0.87512228649537 0.229518434612509 no 2664 0.190753685980115 3923 3965305 YMR134W ERG29
SGTC_2091 4-phenylthiadiazole 200 µM -0.87583154882717 0.22931527431722 no 2665 0.190560808145762 3912 270010
SGTC_1826 st055655 41.6 µM -0.880017908015845 0.228118194170867 no 2666 0.189424804178634 3981 676168
SGTC_1523 st012844 44.7 µM -0.881083898137947 0.22781393891522 no 2667 0.189136205852011 4081 4274103
SGTC_1776 st049249 45.9 µM -0.887553316477328 0.225972341697214 no 2668 0.187390537328461 3999 1822314
SGTC_2560 caryophyllene 100 µM -0.888631219854137 0.225666323685191 no 2669 0.187100653389114 4003 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1447 4239-0816 81.9 µM -0.888784009500103 0.225622965509849 no 2670 0.187059585646306 3962 1341554
SGTC_1047 2043-3044 82 µM -0.890399730834039 0.225164749674448 no 2671 0.186625643431899 3948 669592
SGTC_1604 st002052 72.4 µM -0.890583034833805 0.225112798287677 no 2672 0.186576451973899 4020 6254834 YHR062C RPP1
SGTC_1557 sumaresinolic acid 42.3 µM -0.892043963184203 0.224698989850673 no 2673 0.186184684321407 3915 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2073 5212005 126 µM -0.893599253781923 0.224258927776575 no 2674 0.185768172884505 3762 691789
SGTC_2232 chlorophetanol 41.5365 µM -0.895523064865224 0.223715272183089 no 2675 0.185253770895814 4025 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2925 9010536 32.5 µM -0.89699517167417 0.223299771611809 no 2676 0.184860746729224 3926 2994177
SGTC_2066 5222451 176 µM -0.897550922185422 0.223143025896578 no 2677 0.184712506893072 3936 2281147
SGTC_2353 9059630 146.67 µM -0.898266562753954 0.222941276560222 no 2678 0.184521727175864 4018 4779114
SGTC_1578 josamycin 24.2 µM -0.900965063918126 0.222181465651485 no 2679 0.183803447598619 3971 5282165 A P450 substrate.
SGTC_1740 st038286 13.222 µM -0.901101081980114 0.222143206513749 no 2680 0.183767288852717 4032 716786
SGTC_129 0088-0017 176.636 µM -0.90181402781122 0.221942730747522 no 2681 0.183577833376008 3805 182446
SGTC_1945 st075991 56.6 µM -0.902021290893252 0.221884469095001 no 2682 0.183522778928604 4000 1084980
SGTC_2956 9076196 2.52 µM -0.903294661325509 0.221526716399272 no 2683 0.183184764598564 3989 16423868
SGTC_1516 st013856 110 µM -0.903987766993235 0.221332127415557 no 2684 0.183000944012273 4029 5281404 A mutagen and neurotoxin.
SGTC_2259 7964009 200 µM -0.905949377199214 0.220781936694701 no 2685 0.182481323724954 4023 313134
SGTC_2623 humulene 100 µM -0.907032082979234 0.22047859607114 no 2686 0.182194915751479 3983 6187145 An anti-inflammatory.
SGTC_2528 xanthyletin 44.79 µM -0.909619534914189 0.219754640415597 no 2687 0.181511596352217 4019 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_582 0987-0078 156 µM -0.910571420222052 0.219488651598502 no 2688 0.181260617388992 4011 1625765
SGTC_1600 coumarin 106 71.1 µM -0.911054522146801 0.219353727431213 no 2689 0.18113332343801 4052 100336 A hepatotoxic, DNA x-linker.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.911402739326345 0.219256504407547 no 2690 0.181041605404147 3981 5106787 A p450 inhibitor.
SGTC_3275 9138069 49.47 µM -0.911746079528337 0.219160667302095 no 2691 0.180951200427963 4072 17617007
SGTC_596 1155-0152 116 µM -0.913783058179332 0.218592577681451 no 2692 0.180415425161356 3980 280313
SGTC_1562 morin hydrate 59.1 µM -0.915578640729777 0.218092514387549 no 2693 0.179943969195747 4067 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_222 nsc-310342 10.666 µM -0.915601364760783 0.218086190054688 no 2694 0.179938007637252 3941 432556
SGTC_2195 6536160 144.242 µM -0.915621679137525 0.218080536443024 no 2695 0.179932678346903 3922 3834386
SGTC_2565 isoliquiritigenin 100 µM -0.916916330128017 0.21772040168198 no 2696 0.179593243016659 4088 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2211 7117706 200 µM -0.917293979842366 0.21761541504233 no 2697 0.179494305587901 3927 822771
SGTC_625 k213-0058 121 µM -0.91902008223984 0.217135930565592 no 2698 0.179042534107873 4060 3655420
SGTC_18 0111-0177 500 nM -0.922626442691487 0.216136111788004 no 2699 0.178100955344752 4046 721752
SGTC_629 3448-6466 76.7 µM -0.923337910949 0.215939181370506 no 2700 0.17791556858847 3993 573744
SGTC_659 k018-0002 107 µM -0.923440189135293 0.215910879892411 no 2701 0.177888928045815 4010 6797879 YHR007C ERG11
SGTC_360 0957-0399 1.01 µM -0.923937297823386 0.215773355166054 no 2702 0.177759481281744 4024 6752301 YPR165W RHO1
SGTC_729 4092-0585 94.1 µM -0.926371130467512 0.215100770530123 no 2703 0.177126570931776 4014 2169061
SGTC_2097 5376186 200 µM -0.927987509696438 0.21465476085835 no 2704 0.176707024338372 3972 742755
SGTC_1213 1315-0166 115 µM -0.931928457766487 0.213569585283418 no 2705 0.175686749770925 4118 768401
SGTC_139 0099-0334 718.624 µM -0.933743675798898 0.213070825860699 no 2706 0.175218064840404 4061 97690
SGTC_2243 6634756 200 µM -0.936677922174844 0.212266034562048 no 2707 0.17446212807394 4097 885676
SGTC_1573 oleylamine 1.06 µM -0.936911347030725 0.212202088272813 no 2708 0.174402080954275 4012 5356789 An amine of the fatty acid oleic acid.
SGTC_667 1498-1044 59 µM -0.93920069214352 0.211575523676256 no 2709 0.173813856869803 4030 6739982
SGTC_328 k915-0120 63.5 µM -0.939648649918887 0.211453050159375 no 2710 0.173698906428981 4008 6624543
SGTC_2470 5664817 21.68 µM -0.940810058376213 0.211135709684633 no 2711 0.173401102719636 4035 2859561
SGTC_3130 9127414 49.47 µM -0.941802989355531 0.21086462503536 no 2712 0.173146757206507 4021 1494646
SGTC_1329 1447-1697 50.6 µM -0.942732482550906 0.210611044885011 no 2713 0.172908877120583 4027 2840515
SGTC_54 0159-0055 9 µM -0.944838207608079 0.210037232738716 no 2714 0.172370741188648 4012 3319099
SGTC_3243 9134147 49.47 µM -0.946263614712592 0.209649329786213 no 2715 0.172007073344739 4076 24282180
SGTC_658 3253-0951 102 µM -0.948479858709762 0.209047050035879 no 2716 0.171442610822172 4041 1184878
SGTC_2197 6588183 93.1375 µM -0.949368393209652 0.208805871031647 no 2717 0.171216639874403 3987 884136
SGTC_2692 st077426 47.7 µM -0.951358418871287 0.208266304406915 no 2718 0.17071123038946 4058 25238571
SGTC_1814 st052110 31.539 µM -0.951832742630036 0.208137819896444 no 2719 0.170590906821326 3980 674163
SGTC_958 1222-0007 33 µM -0.952865177436341 0.207858316407805 no 2720 0.170329192803373 4115 7312461
SGTC_2961 9083290 32.55 µM -0.953019803187851 0.207816474806848 no 2721 0.170290018560444 3963 17741490
SGTC_1435 4092-0789 56.7 µM -0.956747506422213 0.206809267713421 no 2722 0.169347356750011 4026 2248285
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.957425513537106 0.20662638461765 no 2723 0.169176262948454 4084 5393153
SGTC_1809 st050081 57.6 µM -0.957729498946487 0.206544419841157 no 2724 0.169099588859268 4123 5036894
SGTC_1629 st005085 44.9 µM -0.959047798052787 0.206189184621771 no 2725 0.168767333213841 4007 24207091
SGTC_2456 5770359 74.46 µM -0.959858980113457 0.205970779719037 no 2726 0.168563096725349 4067 3118787
SGTC_2694 st077685 81.9 µM -0.962322326007276 0.205308383221691 no 2727 0.16794385875003 4003 2838096
SGTC_98 0074-0023 107.663 µM -0.964375003092059 0.204757383817568 no 2728 0.167428974949779 4075 3563821
SGTC_574 1315-0397 40 µM -0.964885265878171 0.204620550770026 no 2729 0.167301141060928 4032 6794277
SGTC_1496 4469-0713 57.4 µM -0.965762142327134 0.204385533018946 no 2730 0.167081608043776 4032 746691
SGTC_816 0325-0417 81.3 µM -0.966899820117298 0.204080855687007 no 2731 0.166797058290424 4078 68101
SGTC_3288 9119690 36.221 µM -0.968105944965875 0.203758143442335 no 2732 0.166495730570237 4054 17595618 YKL019W RAM2
SGTC_2678 equilin 100 µM -0.969176812797526 0.203471875843035 no 2733 0.166228488985849 4068 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2109 5483026 200 µM -0.969392804428384 0.203414165401816 no 2734 0.166174620555017 4060 759335
SGTC_181 1447-1644 8.07 µM -0.969919671028011 0.203273433769277 no 2735 0.166043267044622 4076 534600
SGTC_1634 st006576 41 µM -0.970023932889719 0.203245591213777 no 2736 0.166017281394843 4068 3915356
SGTC_2326 6164455 177.58 µM -0.97015489949706 0.203210620528586 no 2737 0.165984643725783 4037 2888790
SGTC_2244 6635614 200 µM -0.970737201748537 0.203055177752009 no 2738 0.16583958069504 3976 836499
SGTC_1080 nisoldipine 24.4 µM -0.970916329998273 0.203007374613008 no 2739 0.165794972785363 4043 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1166 k206-0078 225 µM -0.971416592050537 0.202873907557292 no 2740 0.165670434723825 4051 5404595
SGTC_2356 9061756 188.97 µM -0.971422595974656 0.202872306063035 no 2741 0.165668940440473 4093 20104043
SGTC_3227 9130768 49.47 µM -0.972989490221906 0.202454608932597 no 2742 0.165279262767147 4100 17720899
SGTC_676 falcarinol 140 µM -0.973524007008834 0.202312237045484 no 2743 0.165146467280076 4046 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1656 st012921 11 µM -0.974519139342971 0.202047336903313 no 2744 0.164899420384406 3970 6732821
SGTC_2727 riluzole 51.77 µM -0.975202936887838 0.20186543318629 no 2745 0.164729802811676 4078 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_607 4491-0986 66.8 µM -0.976319135478724 0.20156871295363 no 2746 0.164453170082111 4075 698981 YDR232W HEM1
SGTC_2349 9023730 187.07 µM -0.979224652339384 0.200797562715631 no 2747 0.163734495190814 4089 4126287
SGTC_13 0199-0087 65 µM -0.979365176049009 0.200760311405553 no 2748 0.163699788640862 4120 4589825
SGTC_545 4218-0007 221 µM -0.979460821556613 0.20073495919225 no 2749 0.163676168842276 4075 2840508
SGTC_2261 9010538 184.68 µM -0.980600927809724 0.20043290568477 no 2750 0.163394788313403 4075 6457250
SGTC_1554 st069299 38.7 µM -0.980895512807156 0.200354904354332 no 2751 0.163322135253441 4048 24207999
SGTC_2589 lobaric acid 100 µM -0.982578058649816 0.199909743138148 no 2752 0.162907573804392 4071 73157 A novel microtubule depolymerizer.
SGTC_329 k048-0121 21.3 µM -0.985440305353583 0.199153829353942 no 2753 0.162203919931793 4098 6832902
SGTC_1714 st033236 13.627 µM -0.986632800030993 0.198839402617118 no 2754 0.161911342257987 4118 2916566
SGTC_2684 capsaicin 100 µM -0.986806752895968 0.198793561245161 no 2755 0.161868691805649 4092 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2270 7924575 90.91 µM -0.988148460994451 0.198440198339646 no 2756 0.161539972492735 4091 1262135
SGTC_881 0833-0569 170 µM -0.990083049352424 0.197931357454898 no 2757 0.161066763884826 4083 5418700
SGTC_2943 9068529 45.32 µM -0.990326818039878 0.19786729668524 no 2758 0.161007201256564 4064 3270634
SGTC_1831 st055328 12 µM -0.993368838699865 0.197068928016362 no 2759 0.160265120801281 4086 1103068
SGTC_2336 9001819 198.65 µM -0.994879497229177 0.196673185973626 no 2760 0.159897437864528 4155 2989602
SGTC_647 0140-0236 81 µM -0.995624343419739 0.196478238481524 no 2761 0.159716351147603 4089 990837
SGTC_534 k292-0788 63.4 µM -0.996390642451034 0.196277798424801 no 2762 0.159530188921404 4126 4146317
SGTC_1944 st076371 56.9 µM -0.996983769930462 0.196122739819418 no 2763 0.159386193986764 4059 24208455
SGTC_734 2023-0417 80 µM -0.998502857152312 0.195725950713524 no 2764 0.159017789851951 4086 3935732
SGTC_3244 9134489 49.47 µM -0.999635259123228 0.195430481946262 no 2765 0.158743526641068 4097 16584271
SGTC_3301 9125354 19.7965 µM -1.00281775073847 0.194601551138923 no 2766 0.157974401332292 4064 41905162
SGTC_2440 5628896 157.78 µM -1.00303719262061 0.194544472951401 no 2767 0.157921458265023 4075 5522048
SGTC_3078 9116413 49.47 µM -1.00317599453883 0.194508374977089 no 2768 0.157887976602026 4018 17177322
SGTC_947 3447-0010 211 µM -1.00444682705997 0.194178061331002 no 2769 0.157581644355395 4045 748350
SGTC_2268 7933382 153.85 µM -1.00570510660137 0.193851347279372 no 2770 0.157278722993095 4102 935025 YOR257W CDC31
SGTC_1197 1601-0112 267 µM -1.00834564220897 0.193166818694801 no 2771 0.156644279341415 4063 7350313
SGTC_2996 9066192 71.4286 µM -1.01260876500621 0.192064771949126 no 2772 0.155623535787687 4148 6472854
SGTC_686 1319-0111 510 µM -1.01267767158327 0.192046990775986 no 2773 0.155607073207227 4157 4562600
SGTC_1720 st037298 9.481 µM -1.0142081828966 0.191652305802541 no 2774 0.155241712415327 4121 597396
SGTC_1783 st039459 87.517 µM -1.01455033055436 0.19156414148876 no 2775 0.155160113071515 4207 729761
SGTC_1790 st045711 43.5 µM -1.01796293551675 0.190686144692569 no 2776 0.154347785308429 4108 585119
SGTC_156 3474-0145 5.642 µM -1.01831080187335 0.190596784377834 no 2777 0.154265138310697 3927 2265471
SGTC_1897 st060201 15 µM -1.01836215657484 0.19058359450031 no 2778 0.154252939806172 4160 611878
SGTC_3201 9113999 49.47 µM -1.02078911096548 0.189960897679479 no 2779 0.153677182255522 4136 16649224
SGTC_1663 st014140 55.4 µM -1.02268714841018 0.189474780536016 no 2780 0.153227894852834 4191 4207120
SGTC_898 1000-0849 28.3 µM -1.02315805557179 0.18935429245678 no 2781 0.153116560583901 4106 6751807
SGTC_2709 st078560 56 µM -1.02366340413348 0.189225044545772 no 2782 0.152997143160057 4118 17250903
SGTC_2460 5552655 174.22 µM -1.02369646833777 0.189216589940974 no 2783 0.152989332008365 4144 5401989
SGTC_3029 9088683 49.47 µM -1.02459411095754 0.188987149218753 no 2784 0.152777372195054 4156 25236615
SGTC_657 3534-0529 86.7 µM -1.02890172711786 0.187888493216063 no 2785 0.151762928356374 4178 1049549
SGTC_3109 9122853 49.47 µM -1.0309050382548 0.18737889571599 no 2786 0.151292676861446 4159 1234709
SGTC_3160 9100216 49.47 µM -1.03265751398713 0.186933806458275 no 2787 0.150882101315664 4062 17191039
SGTC_2005 4024620 188 µM -1.0336038371993 0.186693733962665 no 2788 0.150660702394938 4110 236743
SGTC_1905 st060207 84.5 µM -1.03394702547736 0.186606717797727 no 2789 0.150580464584301 4098 1948547
SGTC_708 3448-5400 146 µM -1.03423019518728 0.18653493838877 no 2790 0.150514280617542 4072 3462195
SGTC_163 TUB2.036 7.546 µM -1.03540241722504 0.186237979062252 no 2791 0.150240508661874 4101 15992207 YJR013W GPI14
SGTC_1348 1493-0373 93.8 µM -1.03611311964689 0.186058079355739 no 2792 0.150074686118885 4128 3010129
SGTC_549 1661-1316 519 µM -1.03724930652911 0.185770700868359 no 2793 0.149809842218631 4160 2857282
SGTC_1841 st054148 70 µM -1.03747246323931 0.185714289670032 no 2794 0.149757861288392 4160 675442
SGTC_1642 st009582 77.7 µM -1.03798146004272 0.185585661473366 no 2795 0.149639343320061 4126 6739311
SGTC_1141 3253-0389 52.6 µM -1.03949920352177 0.185202441973815 no 2796 0.149286314148153 4134 5402031
SGTC_42 0133-0086 60.653 µM -1.03950233006759 0.185201653050671 no 2797 0.149285587483825 4011 162923 Model of phenazepam hydroxylation.
SGTC_3080 9117754 49.47 µM -1.04065680005449 0.184910487641215 no 2798 0.149017429753778 4167 9550191
SGTC_3196 9111891 49.47 µM -1.04066386236967 0.184908707351772 no 2799 0.149015790325728 4119 18891510
SGTC_989 1501-0895 10.3 µM -1.04095490867118 0.184835348798173 no 2800 0.148948238050577 4101 2830112
SGTC_3083 9117465 49.47 µM -1.04134549658399 0.18473692909853 no 2801 0.148857614178424 4126 16420915
SGTC_187 1488-2104 32.728 µM -1.04384947901421 0.184106753888975 no 2802 0.148277517692785 4138 2852859
SGTC_2762 leflunomide 42.06 µM -1.04388161245352 0.184098675598809 no 2803 0.148270083194935 4110 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1210 3013-0140 750 nM -1.04512119566104 0.183787215012032 no 2804 0.147983479513589 4168 905973
SGTC_592 k241-0073 46.5 µM -1.04533583680321 0.183733317132729 no 2805 0.147933890085439 4162 4230158
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.04543260093352 0.18370902220919 no 2806 0.14791153790768 4178 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1488 4013-0813 75.9 µM -1.04544130296066 0.183706837457553 no 2807 0.147909527880468 4062 2910057
SGTC_353 1988-1175 58.3 µM -1.04653408647657 0.18343260929187 no 2808 0.14765725792975 3982 2788357
SGTC_3254 9136651 49.47 µM -1.04664393319143 0.18340505796959 no 2809 0.14763191567675 4105 16454030
SGTC_1816 st051957 91.6 µM -1.04815127164827 0.183027253878163 no 2810 0.147284458518976 4127 674121
SGTC_2723 salbutamol 83.58 µM -1.04859366500162 0.182916463239661 no 2811 0.147182586381022 4174 9884233 β2-adrenoceptor agonist
SGTC_3037 9091026 49.47 µM -1.04911604635497 0.182785694732353 no 2812 0.147062355837349 4082 25236398 YIL048W NEO1
SGTC_615 k087-0205 167 µM -1.04937511370984 0.182720863666423 no 2813 0.147002753701564 4149 9642773
SGTC_2934 9036370 36.88 µM -1.04951892392538 0.182684881656811 no 2814 0.146969675105557 4137 6462800
SGTC_837 0091-0265 12.5 µM -1.05224770375614 0.182002966400681 no 2815 0.146342959116909 4100 759367
SGTC_3122 9126309 49.47 µM -1.05268931433906 0.181892758838444 no 2816 0.146241703827468 4188 17591206
SGTC_2287 7945887 168.79 µM -1.05370809589538 0.181638672748796 no 2817 0.146008290608475 4167 1245853
SGTC_310 1273-0058 1.06 µM -1.05438503561733 0.181469965554279 no 2818 0.145853335319128 4002 2734232
SGTC_280 3448-3607 3.04 µM -1.0568166397445 0.18086476952853 no 2819 0.14529763931816 4118 626179
SGTC_477 mead ethanolamide 10 µM -1.05684657396719 0.18085732716396 no 2820 0.145290807318944 4056 16061185
SGTC_1326 1431-2094 10.8 µM -1.05805777812215 0.180556353833785 no 2821 0.145014550970093 4127 616278
SGTC_356 1634-0012 32.5 µM -1.06003685133209 0.180065248396498 no 2822 0.144563917268664 4164 735457
SGTC_1651 st011928 86.1 µM -1.06502922969994 0.178830124209895 no 2823 0.143431351339047 4181 720198
SGTC_2239 6685329 187.64 µM -1.06717799254142 0.178300161619402 no 2824 0.142945734181797 4220 805680
SGTC_1384 3089-0840 101 µM -1.06961760141249 0.177699666905333 no 2825 0.142395734564567 4151 1069836
SGTC_2706 st078239 82.5 µM -1.06994394058107 0.177619437397685 no 2826 0.142322271463536 4141 15434492
SGTC_2513 baicalein 25.65 µM -1.07136779661383 0.177269654154274 no 2827 0.142002043390249 4167 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3218 9131285 49.47 µM -1.07167444546503 0.177194380030006 no 2828 0.141933141335708 4137 17156417
SGTC_445 e6 berbamine 66 µM -1.07306997475907 0.176852069812738 no 2829 0.141619860682312 4193 6610268 A calcium/calmodulin antagonist.
SGTC_2601 securinine 100 µM -1.07341977913921 0.176766331644771 no 2830 0.141541407011568 4137 442872 A GABA receptor antagonist.
SGTC_2399 5884133 200 µM -1.07459023932031 0.176479639224814 no 2831 0.141279111870263 4165 722445
SGTC_1989 st071868 50.2 µM -1.07461671010934 0.176473158874851 no 2832 0.141273183691893 4154 16414057
SGTC_59 0330-0160 1.33 µM -1.07483866771757 0.176418827052699 no 2833 0.141223482541766 4134 4293482
SGTC_2942 9052777 62.25 µM -1.07595916147106 0.176144708924355 no 2834 0.140972760535475 4235 6469503
SGTC_2636 apigenin dimethyl ether 100 µM -1.0769183925015 0.175910256497496 no 2835 0.140758362727294 4166 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_952 1185-0122 232 µM -1.07719760207519 0.175842050065657 no 2836 0.140695998167465 4117 678600
SGTC_1317 1273-0028 910 nM -1.0773524001325 0.175804242595446 no 2837 0.140661430382972 4160 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1126 isoteolin 1.0172 µM -1.08137462763653 0.174823669884962 no 2838 0.139765251612115 4117 133323
SGTC_2075 5212009 200 µM -1.08143611440321 0.174808707109259 no 2839 0.139751582145184 4090 780898
SGTC_52 0329-0193 875 nM -1.082428669051 0.174567281880016 no 2840 0.139531047523843 4256 3739292
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.08418743675775 0.17414000618793 no 2841 0.139140850423637 4215 6708784 An antioxidant flavonoid
SGTC_2849 9019321 12.99 µM -1.08430655627986 0.174111091301119 no 2842 0.139114449656479 4206 16489627
SGTC_3295 9122362 53.5725 µM -1.08446896238724 0.174071674013282 no 2843 0.139078460665171 4199 4730473
SGTC_684 1140-0066 328 µM -1.08555380321473 0.173808519812434 no 2844 0.138838223847406 4224 6813534
SGTC_3208 9114115 49.47 µM -1.08599467357249 0.173701648464985 no 2845 0.138740674392543 4202 650895
SGTC_2666 tannic acid 100 µM -1.08883061875983 0.173015186912787 no 2846 0.138114293302175 4173 16134267 A thiamine antagonist.
SGTC_1 0258-0098 57.368 µM -1.08908173887361 0.17295448483475 no 2847 0.13805892096981 4126 6790032 YDR047W HEM12
SGTC_2029 5175081 200 µM -1.09016206843188 0.172693496660391 no 2848 0.137820879488535 4140 1380876
SGTC_1252 0493-0875 34.8 µM -1.09198261254276 0.172254254333138 no 2849 0.137420371879798 4173 3960963
SGTC_3143 9086658 49.47 µM -1.09280882083049 0.172055150589898 no 2850 0.137238873962729 4227 25236626
SGTC_1771 st048882 4.1505 µM -1.09498358326248 0.171531768209074 no 2851 0.13676191437479 4220 4580403
SGTC_3067 9117431 49.47 µM -1.09645091034891 0.171179213934867 no 2852 0.136440747432169 4222 17150885
SGTC_2649 anisomycin 9.56 µM -1.09751090572704 0.170924817622737 no 2853 0.136209058017044 4217 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1994 st072947 40.9 µM -1.10054363363345 0.170198307149887 no 2854 0.135547664585523 4240 5286565 YDL195W SEC31
SGTC_343 4130-2827 29.8 µM -1.10114172113021 0.170055265167066 no 2855 0.135417490688148 4206 1118244
SGTC_47 0149-0135 24.25 µM -1.10136972294671 0.17000075525678 no 2856 0.135367888597618 4214 5239155
SGTC_118 0083-0097 135.343 µM -1.10450774564164 0.169251665388477 no 2857 0.13468647272753 4203 5207356
SGTC_2016 5121758 140 µM -1.10606522938357 0.168880660328928 no 2858 0.134349143566876 4108 2795203
SGTC_3055 9094636 49.47 µM -1.10980725359082 0.167991417773973 no 2859 0.133541046472328 4234 25236176
SGTC_2947 9072639 7.68 µM -1.11145869527911 0.167599934715599 no 2860 0.133185479853204 4202 16488146
SGTC_787 4152-0075 138 µM -1.11172472972983 0.1675369248307 no 2861 0.133128261814294 4222 9566539
SGTC_1804 st050076 49.1 µM -1.11190608855532 0.167493978997115 no 2862 0.133089265300776 4231 3895976
SGTC_1833 st055984 71 µM -1.11330138030947 0.16716381063176 no 2863 0.132789506915932 4205 676288
SGTC_221 trifluoperazine 10.304 µM -1.11408833448856 0.166977778582969 no 2864 0.13262064634003 4173 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2049 5262831 67.185 µM -1.11927823500121 0.165754257437416 no 2865 0.131510729057045 4201 763417
SGTC_136 0097-0015 404.482 µM -1.12134468286339 0.165268709001635 no 2866 0.131070586339096 4209 4861337
SGTC_1854 st056233 32.9 µM -1.12437527443501 0.164558284538205 no 2867 0.130426928410385 4158 5393174
SGTC_722 3534-0461 190 µM -1.12815155963128 0.163675829910453 no 2868 0.129627958698814 4264 658262
SGTC_3318 9139014 38.6185 µM -1.12878507342363 0.163528089826151 no 2869 0.129494255438134 4220 16643984
SGTC_1571 st070080 73.4 µM -1.13006431824733 0.163230024586521 no 2870 0.129224561807028 4250 4315245
SGTC_813 k007-0158 173 µM -1.13025437998329 0.163185770164072 no 2871 0.129184525755535 4211 6523916
SGTC_1716 st033144 30.6155 µM -1.13086447193322 0.163043767604793 no 2872 0.129056069445513 4248 674617
SGTC_1763 st044482 94.5 µM -1.13124552080745 0.162955116957488 no 2873 0.128975883647922 4203 88505
SGTC_3010 9080089 71.4286 µM -1.13202015423281 0.162774995875396 no 2874 0.128812980644566 4244 17027233
SGTC_1486 3970-0793 4.53 µM -1.1350336123073 0.162075525840763 no 2875 0.128180617681906 4247 2844330
SGTC_2228 7354201 200 µM -1.13645655497116 0.161745920353328 no 2876 0.127882769068539 4299 753451
SGTC_104 0074-0074 590.992 µM -1.13911877449863 0.161130427110738 no 2877 0.127326808911632 3993 3943124
SGTC_1263 0774-1208 64.8 µM -1.13944811621147 0.161054391141559 no 2878 0.127258148420829 4274 906585
SGTC_1042 0350-0096 82 µM -1.14125650234442 0.160637301724472 no 2879 0.12688159877486 4210 3122515
SGTC_115 0527-0192 112.043 µM -1.14368987073989 0.160077179614662 no 2880 0.126376137818109 4223 4233931
SGTC_15 0266-0086 27.098 µM -1.14375540285036 0.160062112860754 no 2881 0.126362544871988 4290 1712902 YIL048W NEO1
SGTC_2288 7946289 167.31 µM -1.14392151152951 0.160023926293258 no 2882 0.126328094474798 4303 1246052
SGTC_2337 9009472 200 µM -1.14512569457606 0.159747275938219 no 2883 0.126078546546811 4212 5742383
SGTC_1626 st003712 1.76 µM -1.14634504472929 0.159467460125459 no 2884 0.125826205873679 4279 24207035
SGTC_2224 6650123 117.647 µM -1.14682493223471 0.15935742384032 no 2885 0.125726991329859 4244 2908370
SGTC_2296 7971656 126.45 µM -1.14685575880577 0.15935035713067 no 2886 0.12572061994345 4271 666570
SGTC_1296 1068-0102 11.9 µM -1.14851500135714 0.158970293704566 no 2887 0.125378011880494 4233 767053
SGTC_306 1672-3436 11.6 µM -1.1502172435138 0.158580998649995 no 2888 0.125027202906889 4273 6797378
SGTC_1963 st076565 50.3 µM -1.1515675766625 0.158272628626859 no 2889 0.124749405682337 4257 4914280
SGTC_2281 7943571 200 µM -1.15222846929161 0.15812184680718 no 2890 0.124613600913018 4346 1244024
SGTC_1049 3226-0134 66 µM -1.15937407402298 0.156497608600692 no 2891 0.123151869932735 4265 5702385
SGTC_2098 5376439 882.5 nM -1.15955549660189 0.156456513687968 no 2892 0.123114914555159 4290 2844116
SGTC_1930 st074634 34.3 µM -1.1609995390126 0.156129670003597 no 2893 0.122821043457743 4152 684253 YOR116C RPO31
SGTC_1901 st060216 58.6 µM -1.1611189415062 0.156102664668669 no 2894 0.122796766388009 4213 688792
SGTC_1689 st020265 53.493 µM -1.16215776386176 0.155867843471131 no 2895 0.122585693682202 4260 5758320 YPR016C TIF6
SGTC_326 k292-0812 17.5 µM -1.16355816911455 0.155551656813886 no 2896 0.12230155594508 4240 3579357
SGTC_470 aa-861 153 µM -1.16437852057631 0.155366632672596 no 2897 0.122135324147852 4217 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_576 1073-0113 22.7 µM -1.1668513899496 0.154809774540046 no 2898 0.121635194734726 4387 5439563
SGTC_1676 st018489 23.4 µM -1.16745264805311 0.154674578520521 no 2899 0.121513810154581 4280 3696235
SGTC_1230 0170-0365 3.77 µM -1.16852482051838 0.154433688612302 no 2900 0.121297566705302 4306 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2282 7944268 200 µM -1.17020144971777 0.154057490068227 no 2901 0.120959954786424 4275 2970414
SGTC_2991 9074669 71.4286 µM -1.17282180081941 0.153470756387074 no 2902 0.120433636874575 4253 17333109
SGTC_2764 methyldopa 94.69 µM -1.17331246359379 0.153361054785437 no 2903 0.120335262996689 4269 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1534 6-azauridine 81.6 µM -1.17338938575096 0.153343861363604 no 2904 0.120319845866589 4281 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2284 7945075 39.21 µM -1.17627079092727 0.152700737710294 no 2905 0.11974334197349 4242 1245402
SGTC_155 k072-0202 43.6 µM -1.17787055770868 0.152344446620354 no 2906 0.11942410714938 4255 5857737
SGTC_2718 lomofungin 53.02 µM -1.1781534778325 0.152281493706286 no 2907 0.119367712746101 4242 5351222 A RNA synthesis inhibitor.
SGTC_1390 3413-2614 145 µM -1.17884940958406 0.152126714549431 no 2908 0.119229072801524 4285 3421432
SGTC_1467 k284-1082 293 µM -1.17959404941151 0.151961218171941 no 2909 0.11908085539179 4237 3334705
SGTC_274 sirtinol 40.1 µM -1.17966744589222 0.151944912264231 no 2910 0.119066253178619 4320 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2592 piperlongumine 83.33 µM -1.18204864834283 0.151416530140486 no 2911 0.118593199169251 4284 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_821 1114-0266 29.2 µM -1.18305793098249 0.151192942292653 no 2912 0.118393094526799 4276 3123235
SGTC_1555 citronellol 128 µM -1.18353569007843 0.15108718025793 no 2913 0.118298455264789 4231 8842 A terpine precursor.
SGTC_2959 9079155 11 µM -1.18378882172805 0.151031164193059 no 2914 0.118248334118159 4302 16189457
SGTC_1427 4048-4900 550 nM -1.18432398556197 0.150912782101064 no 2915 0.118142418828578 4277 24132586
SGTC_146 3448-8650 53.125 µM -1.18458747939575 0.150854518065544 no 2916 0.118090294919896 4245 2891488 YIL048W NEO1
SGTC_2516 gossypol 71.55 µM -1.18759696288164 0.150190120171235 no 2917 0.11749611748575 4294 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2119 5528445 120.635 µM -1.18813354136129 0.150071865956409 no 2918 0.117390400838547 4290 791935
SGTC_1028 k015-0029 4.8 µM -1.18844496499958 0.150003261121264 no 2919 0.117329075079956 4237 4588309
SGTC_493 zm226600 134 µM -1.18866971392407 0.149953763220168 no 2920 0.117284831464345 4302 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1344 1488-0097 29.1 µM -1.1890430764653 0.149871559264778 no 2921 0.117211358198283 4325 747966
SGTC_832 4083-0019 164 µM -1.19004917104644 0.149650195106898 no 2922 0.117013533187242 4357 1990758
SGTC_501 nsc-95397 161 µM -1.19153831941472 0.149322948512365 no 2923 0.116721161380166 4305 262093
SGTC_1670 st016595 4.04 µM -1.19218653944653 0.149180648804996 no 2924 0.116594055093061 4299 597879
SGTC_1218 1348-1416 30.7 µM -1.1932508644367 0.148947200646896 no 2925 0.116385569779351 4234 6787668
SGTC_3321 9137793 26.8275 µM -1.19426087990901 0.14872589052255 no 2926 0.116187967588506 4250 4904192
SGTC_2011 4012611 177 µM -1.19465446795227 0.148639708793893 no 2927 0.116111029451075 4255 2049887
SGTC_383 2324-0395 7.37 µM -1.19572615320915 0.148405217226416 no 2928 0.115901720950505 4270 3146421
SGTC_521 r062-0005 13.8 µM -1.19632511275251 0.148274268898 no 2929 0.115784856248634 4205 2832033
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.19859356599026 0.147779026203368 no 2930 0.115343010599818 4348 165506
SGTC_1328 1441-0025 69.2 µM -1.19870700976148 0.147754288574974 no 2931 0.115320945712915 4270 4562601
SGTC_483 fpl-64176 144 µM -1.20479379360485 0.146431065589896 no 2932 0.114141458267018 4406 3423
SGTC_828 2074-0507 139 µM -1.20740406796593 0.145866055556128 no 2933 0.113638284840787 4368 X828
SGTC_1925 st057770 10.1 µM -1.20778634275787 0.145783432975375 no 2934 0.113564728027302 4274 5989122
SGTC_307 1501-1223 22.3 µM -1.20790950884104 0.145756819298492 no 2935 0.113541035803721 4324 2830329
SGTC_377 3970-0964 33.1 µM -1.20823218292417 0.145687111500922 no 2936 0.113478982939671 4249 16481235
SGTC_1612 st002233 45.4 µM -1.21214802743859 0.144842951764109 no 2937 0.112727860994286 4300 1035021
SGTC_630 4356-0227 183 µM -1.2123160400292 0.144806806222309 no 2938 0.112695713094077 4238 779312
SGTC_2234 tolnaftate 200 µM -1.21313136285458 0.144631487267284 no 2939 0.112539800394676 4360 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1954 st077032 68.9 µM -1.21900962547845 0.143371716309957 no 2940 0.111420269583533 4256 698907
SGTC_3088 9117578 49.47 µM -1.22098761041668 0.142949485211258 no 2941 0.111045355409692 4363 678341
SGTC_1493 4348-0038 111 µM -1.22129915265785 0.142883058438169 no 2942 0.11098638706175 4274 800424
SGTC_2193 5925765 200 µM -1.22144831019731 0.142851262580028 no 2943 0.110958162639778 4309 877370
SGTC_2231 micatex 6.853 µM -1.2230742602605 0.142504969608404 no 2944 0.110650824745639 4313 20737 An antifungal of unknown mechanism.
SGTC_178 4092-0806 87.505 µM -1.22308679577462 0.142502302016413 no 2945 0.110648457648844 4195 2169044
SGTC_2190 6049624 200 µM -1.22481467176766 0.142134928379234 no 2946 0.110322527851403 4188 2265554
SGTC_1675 st018485 24.5 µM -1.2260969056051 0.141862719967969 no 2947 0.110081105093833 4339 3323024
SGTC_2587 piperic acid 92.2 µM -1.22681287748642 0.141710878315114 no 2948 0.109946464821661 4287 5370536
SGTC_1903 st060211 78.3 µM -1.22705197716229 0.141660195140142 no 2949 0.109901527871659 4331 688960
SGTC_508 roscovitine 141 µM -1.23033850926523 0.140964776583307 no 2950 0.109285184696084 4371 160355 A CDKinase inhibitor.
SGTC_1223 0764-0573 147 µM -1.23405450372627 0.140181278904487 no 2951 0.108591297601703 4305 1609797
SGTC_2753 fluvastatin 17.09 µM -1.23755321440335 0.139446302953877 no 2952 0.107940885640702 4315 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2154 5570129 200 µM -1.2378837922337 0.139376994083538 no 2953 0.107879576432514 4364 673366
SGTC_2118 5526350 200 µM -1.24425464097039 0.138045860616514 no 2954 0.106702929653294 4361 743594
SGTC_81 0411-0046 9.971 µM -1.2461933684505 0.137642506728494 no 2955 0.106346706545865 4292 12925265
SGTC_2132 5317594 122.667 µM -1.24663803170732 0.137550107679595 no 2956 0.106265125031871 4260 794577
SGTC_1693 xanthone 101.9 µM -1.24677677900623 0.137521285276481 no 2957 0.106239678586171 4369 7020 An insecticide.
SGTC_195 4234-0266 16.654 µM -1.24763429082329 0.13734324319487 no 2958 0.106082507391936 4343 2303354
SGTC_3242 9133940 49.47 µM -1.25115448522019 0.136614007789723 no 2959 0.105439060121732 4333 17248444
SGTC_569 4130-2812 160 µM -1.2524909770714 0.13633783789695 no 2960 0.105195507050037 4178 743552
SGTC_556 4058-0063 51.5 µM -1.25346398968226 0.136137017022766 no 2961 0.105018448185507 4371 6615692
SGTC_784 4579-0127 173 µM -1.25877347636676 0.135044754932081 no 2962 0.104056081594535 4357 1948547
SGTC_2120 5538279 151.968 µM -1.26136923942985 0.13451295053069 no 2963 0.103587922809807 4297 2058197
SGTC_2436 5633522 8.09 µM -1.26340533499828 0.13409681485058 no 2964 0.103221773919883 4316 5724242
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.26562805391054 0.133643547949535 no 2965 0.102823138678981 4333 7104
SGTC_3171 9103192 49.47 µM -1.26961580157523 0.132832991263046 no 2966 0.102110758984182 4418 13018434
SGTC_1023 4482-3888 16 µM -1.27155824434341 0.132439395473167 no 2967 0.101765060317255 4368 3303168
SGTC_2308 7584454 197.62 µM -1.27203276045914 0.132343366881769 no 2968 0.101680739805523 4388 893577
SGTC_1908 st060353 56.5 µM -1.27404363772033 0.131936955065878 no 2969 0.101323975698983 4400 4227716
SGTC_3087 9117406 49.47 µM -1.27454926429701 0.131834900117658 no 2970 0.101234412531613 4365 42546093
SGTC_1821 st053465 65.6 µM -1.27468875124486 0.131806755857374 no 2971 0.101209714940999 4361 675086
SGTC_751 0833-0568 350 µM -1.2758170505083 0.131579251460984 no 2972 0.101010099400161 4367 6954252
SGTC_2549 cedrol 20.94 µM -1.28066721805497 0.130604376345332 no 2973 0.100155289470065 4294 6708665 A sedative which affects the nervous system.
SGTC_860 0443-0016 25.1 µM -1.28095530646695 0.130546628625754 no 2974 0.100104682458088 4376 5337942
SGTC_1531 st059297 52.4 µM -1.29256396765081 0.128234336458664 no 2975 0.0980809542855132 4380 7566702
SGTC_1064 honokiol 6.76 µM -1.29360751903037 0.128027876839929 no 2976 0.0979005119798434 4387 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1614 st002383 48.6 µM -1.29433109060688 0.127884858707952 no 2977 0.0977755408595844 4392 1947235
SGTC_3079 9117512 49.47 µM -1.29436299477706 0.127878555219503 no 2978 0.0977700332479918 4432 7185044
SGTC_713 1488-1073 324 µM -1.29549714038862 0.127654615860848 no 2979 0.0975743935984341 4387 3312542
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.29870487033081 0.127022719501418 no 2980 0.0970226160168462 4320 688761
SGTC_169 k015-0017 16.025 µM -1.30622270116565 0.12555030817817 no 2981 0.0957384175099347 4359 1840002
SGTC_174 3553-0389 74.3 µM -1.30691278111432 0.125415751242135 no 2982 0.0956211674043014 4424 738071
SGTC_3356 9151811 4.48 µM -1.30763397575605 0.125275234933891 no 2983 0.0954987436159077 4374 1859254 YPR165W RHO1
SGTC_618 k072-0232 33.2 µM -1.30890245503758 0.125028353400529 no 2984 0.0952836974567908 4416 5872756 YGL099W LSG1
SGTC_950 1165-0508 94.1 µM -1.30996827500683 0.124821177929496 no 2985 0.0951032840865817 4360 6148369
SGTC_530 4358-1714 28 µM -1.31188217370722 0.124449754192644 no 2986 0.0947799465606518 4374 1564641
SGTC_2775 cyproheptadine 69.59 µM -1.3137263125573 0.124092600227783 no 2987 0.0944691614289652 4381 2913 A selective serotonin reuptake inhibitor.
SGTC_46 0329-0187a 2.197 µM -1.3148565906147 0.123874054325876 no 2988 0.0942790520765569 4407 46494817
SGTC_2188 6126565 140.678 µM -1.31632691838813 0.123590161189562 no 2989 0.0940321698689973 4275 874518
SGTC_440 fluspirilene 35.1 µM -1.31686574641457 0.123486237621739 no 2990 0.09394181499295 4421 3396 An atypical antipsychotic.
SGTC_2376 9072922 81.32 µM -1.31899972992314 0.123075258285962 no 2991 0.0935846013796755 4385 17087968
SGTC_711 k292-0785 179 µM -1.3190829772612 0.123059245312117 no 2992 0.0935706867250566 4306 4146315
SGTC_263 alizarin 107.927 µM -1.32131761731465 0.122629948624759 no 2993 0.09319774109203 4424 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_772 k072-0172 35.3 µM -1.3248217118671 0.121958894374436 no 2994 0.0926151458848266 4430 5861980
SGTC_1057 3448-5381 134 µM -1.3252729505389 0.121872667389592 no 2995 0.0925403185944151 4354 5497911
SGTC_2811 7967822 32.47 µM -1.32760617709611 0.121427495470734 no 2996 0.0921541214183128 4418 2232244
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.32761160095097 0.121426461950765 no 2997 0.0921532250504811 4426 23665772 A membrane-active detergent.
SGTC_220 paclitaxel 373.376 µM -1.32916542742627 0.121130633678644 no 2998 0.0918966992149547 4349 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2182 6325192 200 µM -1.33002276319186 0.12096762534667 no 2999 0.0917553857052985 4403 736248
SGTC_687 k029-0044 34.9 µM -1.33370993083587 0.120268330467908 no 3000 0.0911494694474447 4463 5829338
SGTC_1937 st074714 47.2 µM -1.33456963139405 0.120105693020804 no 3001 0.0910086214673369 4331 17250970
SGTC_2933 9026794 32.47 µM -1.33691268877598 0.119663222380519 no 3002 0.0906255692368891 4327 17586027
SGTC_2023 5144124 124 µM -1.33700035274474 0.119646689969885 no 3003 0.0906112608470641 4376 2830192
SGTC_926 2268-1401 59.4 µM -1.33771515345211 0.119511946942456 no 3004 0.090494654655129 4357 2931578
SGTC_2624 nerol 100 µM -1.33999296781515 0.119083283294509 no 3005 0.0901238155870357 4307 637566 A natural product oil.
SGTC_126 0417-1624 672.48 µM -1.34004597333981 0.119073321084413 no 3006 0.0901151994958497 4446 41912 YDL195W SEC31
SGTC_369 0957-0393 4.5 µM -1.3403087226458 0.119023946923594 no 3007 0.0900724984174373 4393 6997992
SGTC_3320 9137005 35.139 µM -1.34156516432443 0.11878804432271 no 3008 0.089868513814283 4443 4908713
SGTC_1853 st056710 91.2 µM -1.34169269118641 0.118764119053488 no 3009 0.0898478289052528 4438 269167
SGTC_1090 efavirenz 20.7 µM -1.34245414334732 0.118621334127406 no 3010 0.089724394694747 4424 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1953 st076800 12.1 µM -1.34363808902318 0.118399565645658 no 3011 0.0895327231867056 4386 297591
SGTC_3089 9117425 49.47 µM -1.35069181314178 0.117084385007532 no 3012 0.0883970879497651 4379 9401657
SGTC_3123 9126162 49.47 µM -1.35291343745906 0.116672310403747 no 3013 0.0880416430122415 4422 25239884
SGTC_943 3253-1379 105 µM -1.35449803182256 0.116379023333449 no 3014 0.0877887704444102 4394 668464
SGTC_2280 7785178 200 µM -1.35492425471571 0.116300224557548 no 3015 0.0877208455388426 4395 2954328
SGTC_2833 9001315 45.46 µM -1.35963893722203 0.115431113217558 no 3016 0.0869721050569807 4345 2989378
SGTC_2875 9039966 71.43 µM -1.36324020617371 0.114770366462728 no 3017 0.0864034098517107 4394 6463691
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.36360266113878 0.114704013990591 no 3018 0.0863463270599577 4443 6710655
SGTC_1774 st048371 48.465 µM -1.36449439715961 0.114540885385316 no 3019 0.0862060081937719 4398 4242727
SGTC_1996 st072960 66.8 µM -1.36501787453475 0.114445200664863 no 3020 0.0861237160510132 4438 1719405
SGTC_3062 9077494 49.47 µM -1.36515921556629 0.114419375158031 no 3021 0.0861015069150712 4366 16459633
SGTC_1400 3771-8998 51.5 µM -1.36646180342892 0.114181564603305 no 3022 0.0858970309205645 4350 670767
SGTC_2134 5324836 1.464 µM -1.36670818928441 0.114136622107294 no 3023 0.0858583949772095 4388 699272
SGTC_204 PMA1.184 62.41 µM -1.37333256954582 0.112933009342423 no 3024 0.0848244909318843 4383 2252213 YGL008C PMA1
SGTC_1636 st007707 68.9 µM -1.37386819590875 0.112836086420121 no 3025 0.0847413024162053 4426 403051
SGTC_410 α-linolenic acid 100 µM -1.37453424655065 0.112715645755745 no 3026 0.084637942969025 4443 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1880 MG-132 525 µM -1.37504831331339 0.112622750834261 no 3027 0.0845582334439278 4374 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.37660946844777 0.112340976013961 no 3028 0.0843165109652044 4346 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_980 1473-0395 201 µM -1.37720738366831 0.112233191079052 no 3029 0.0842240698318752 4315 768876
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.37769486559257 0.112145368433455 no 3030 0.0841487586300299 4521 16725076
SGTC_2369 9071472 200 µM -1.38197807307555 0.111375835594111 no 3031 0.0834892169058439 4442 17296037
SGTC_1131 3454-3128 32.3 µM -1.38846120504085 0.11021826035542 no 3032 0.0824983250993521 4429 710982
SGTC_2657 nystatin 74.44 µM -1.38965673177811 0.110005742620087 no 3033 0.0823165698015441 4453 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_495 decylubiquinone 155 µM -1.39147539887577 0.109683019062921 no 3034 0.0820406573109755 4421 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1289 0976-0073 69.1 µM -1.39231194947065 0.10953480111253 no 3035 0.0819139772761414 4485 3391136
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.39689926496952 0.108724588529699 no 3036 0.0812219328391973 4452 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1654 st012436 41.8 µM -1.40269870667994 0.107706470234685 no 3037 0.0803533515782047 4431 4323132
SGTC_2682 pyrogallin 40.03 µM -1.40291829178841 0.107668056483644 no 3038 0.0803206028043687 4443 822798 An ATP competetive kinase inhibitor.
SGTC_229 benomyl 22.8748 µM -1.40454575094446 0.107383659899299 no 3039 0.0800781989735863 4453 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1122 capsaicin 818.572 nM -1.40468936924907 0.107358588794267 no 3040 0.0800568341600719 4486 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_282 k297-0036 65.7 µM -1.40540149557572 0.107234336931021 no 3041 0.0799509611376311 4444 5061378
SGTC_294 k038-0071 157 µM -1.40558010843208 0.107203188815196 no 3042 0.07992442307785 4453 24152826
SGTC_441 propafenone 146 µM -1.40725672365052 0.106911123576721 no 3043 0.0796756384708493 4426 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_442 cape 100 µM -1.41165172904134 0.106148242334455 no 3044 0.0790262665049963 4450 5281787
SGTC_3013 9080133 71.4286 µM -1.4143932714653 0.105674363802425 no 3045 0.0786232322915431 4503 17050193
SGTC_311 1315-0136 58 µM -1.41617133373847 0.105367842661247 no 3046 0.0783626733651358 4463 6759207
SGTC_1294 1000-1494 117 µM -1.42687974734697 0.103535407698048 no 3047 0.0768072797169304 4449 712797 YDL207W GLE1
SGTC_1190 1486-1332 13 µM -1.42866298344811 0.103232518549575 no 3048 0.076550560975194 4450 4150046
SGTC_1172 0370-0043 85 µM -1.42977941916613 0.103043215675783 no 3049 0.0763901688828051 4478 376585
SGTC_2893 9048488 25.97 µM -1.42999012168374 0.103007517252243 no 3050 0.0763599271300859 4486 6467338
SGTC_2153 5569715 200 µM -1.43316233510069 0.102471148138064 no 3051 0.0759057253631161 4468 2054701
SGTC_96 0929-0093 37.281 µM -1.43518272497326 0.102130593675399 no 3052 0.0756175174899557 4462 6991579
SGTC_7 0192-1582 4.227 µM -1.43690155527309 0.101841518574979 no 3053 0.0753729839777705 4513 252616
SGTC_2895 9054447 58.44 µM -1.44055559515361 0.101228957215772 no 3054 0.0748551364989053 4523 2697450
SGTC_809 3998-0021 90 µM -1.44408424425728 0.100639968655207 no 3055 0.0743576397417142 4411 715485
SGTC_3154 9100113 49.47 µM -1.44603742442543 0.100315028029468 no 3056 0.0740833526299538 4447 25237525
SGTC_1018 4259-0013 28.1 µM -1.44770519619298 0.100038175947341 no 3057 0.0738497580513225 4502 6801262
SGTC_3033 9090887 49.47 µM -1.45078370358151 0.099528606244593 no 3058 0.0734200494498726 4474 19325384
SGTC_2868 9035608 32.47 µM -1.45637634431815 0.0986077429182818 no 3059 0.0726443056332684 4452 6462614
SGTC_2822 7994718 71.43 µM -1.45804265607487 0.0983345839681268 no 3060 0.0724143929113145 4474 1018011
SGTC_993 3909-8757 62.7 µM -1.45855693490903 0.098250390111825 no 3061 0.0723435469522286 4419 4288324 YLR208W SEC13
SGTC_2266 7929956 200 µM -1.46042162738735 0.0979455595181812 no 3062 0.0720871162203126 4417 2967153
SGTC_1003 4049-0218 100 µM -1.46050273133862 0.0979323167967486 no 3063 0.0720759787151162 4473 295161
SGTC_2688 kanamycin b 96.69 µM -1.46592034172988 0.0970506936817444 no 3064 0.0713349947601702 4462 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1156 4092-0367 4.88 µM -1.4666786800635 0.0969277534051831 no 3065 0.0712317426155251 4523 1357585
SGTC_2026 5148700 152 µM -1.46728729218199 0.096829169172481 no 3066 0.0711489595851586 4454 79838
SGTC_788 1182-0090 188 µM -1.47026042301425 0.096348633597869 no 3067 0.0707456177617371 4480 5715185
SGTC_1865 st057639 52.2 µM -1.47298373376818 0.095910015432629 no 3068 0.0703777109547319 4470 688818
SGTC_1395 3486-0190 4.35 µM -1.47305743911955 0.0958981648464436 no 3069 0.0703677741844182 4462 6748079
SGTC_3281 9140613 49.47 µM -1.47666367854762 0.0953196565870372 no 3070 0.0698829064853471 4461 16013766
SGTC_644 1498-1197 63.3 µM -1.47945743661438 0.0948732548367454 no 3071 0.0695090495150478 4517 6741615
SGTC_2874 9043904 71.43 µM -1.48172551427932 0.0945119835018127 no 3072 0.069206672669687 4415 4463428
SGTC_761 k216-0224 480 µM -1.48922544768299 0.0933245773997877 no 3073 0.0682140059157762 4505 1340404
SGTC_2984 9022109 38.96 µM -1.49032876853295 0.093150831251011 no 3074 0.0680689058695987 4502 6459207
SGTC_912 3474-0017 2.18 µM -1.49175656385821 0.092926343268754 no 3075 0.0678814873371358 4493 3360550
SGTC_1175 0741-0056 27.6 µM -1.49258799075826 0.0927958049075279 no 3076 0.0677725344205514 4548 765927
SGTC_210 3551-0445 56.827 µM -1.49378016377926 0.0926088642097123 no 3077 0.0676165439086515 4487 2865180 YOR207C RET1
SGTC_1076 itraconazole 331 nM -1.49729709981925 0.0920590083657374 no 3078 0.0671579845936352 4498 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3131 9127911 49.47 µM -1.49837879437866 0.0918903777144726 no 3079 0.0670174313470135 4486 45595681
SGTC_3147 9097027 49.47 µM -1.49946850558366 0.0917207287442087 no 3080 0.0668760665920341 4505 25236841
SGTC_1286 0929-0070 131 µM -1.50117114740247 0.0914561218914527 no 3081 0.066655650263179 4551 1420408
SGTC_3145 9085516 49.47 µM -1.50200650549636 0.0913265063239161 no 3082 0.066547714367832 4474 25236195
SGTC_2726 cimetidine 79.27 µM -1.50306117358456 0.0911630568209102 no 3083 0.0664116349127515 4489 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1735 st034310 56.75 µM -1.50665207489986 0.0906081756838585 no 3084 0.0659499309422625 4519 871153
SGTC_2797 7859098 81.82 µM -1.50738213689759 0.0904956707454779 no 3085 0.0658563674118484 4453 972681
SGTC_209 4077-0173 175.592 µM -1.51305837221795 0.0896244801537931 no 3086 0.0651324161488501 4473 15993494
SGTC_1824 st053723 68.6 µM -1.51307933513957 0.0896212743560025 no 3087 0.0651297540149255 4524 675225
SGTC_2916 7875993 68.79 µM -1.5156873091163 0.0892231094058142 no 3088 0.0647992190806783 4401 1299250
SGTC_810 3825-7150 143 µM -1.51673146094978 0.0890640660299183 no 3089 0.0646672488636689 4528 22330411 YGL099W LSG1
SGTC_901 1112-0062 60.1 µM -1.51985232828621 0.0885899589094886 no 3090 0.0642740470139762 4490 1908457
SGTC_2043 5101342 149 µM -1.52197254758401 0.0882689395057548 no 3091 0.0640079797376019 4532 678451
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.5272983405151 0.0874663940232021 no 3092 0.0633434209785127 4520 15053
SGTC_1569 carminic acid 40.6 µM -1.52985604786051 0.0870829135262129 no 3093 0.0630261823443509 4582 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2990 9074105 71.4286 µM -1.53221795764804 0.086729905671044 no 3094 0.062734329292041 4443 6502001
SGTC_1233 0325-0408 14.2 µM -1.53375460060501 0.0865008159552906 no 3095 0.062545017840311 4541 12874
SGTC_3092 9117248 49.47 µM -1.53389949478389 0.0864792378342909 no 3096 0.0625271901579686 4625 17141857
SGTC_1655 st012546 55.1 µM -1.53558571917951 0.0862284155746819 no 3097 0.0623200094462836 4507 720985 YLR208W SEC13
SGTC_1796 st049173 110.4 µM -1.53863246024615 0.0857765997815493 no 3098 0.0619470246669916 4503 94134
SGTC_2063 5246145 200 µM -1.53884242798309 0.0857455280567126 no 3099 0.0619213845320847 4552 711240
SGTC_1464 k208-0027 110 µM -1.54238029914238 0.0852232484133202 no 3100 0.061490603052275 4509 X1464
SGTC_760 0568-0725 82.9 µM -1.5448180209102 0.0848647682091831 no 3101 0.0611951435420732 4525 3916171
SGTC_930 2810-3379 265 µM -1.54578286764495 0.0847231949681901 no 3102 0.0610785079993315 4511 1015764
SGTC_1587 estradiol valerate 56.1 µM -1.54620976422257 0.0846606124143941 no 3103 0.061026958064318 4563 13791 A steroid.
SGTC_1764 st044502 93.5 µM -1.54646967661957 0.0846225265362125 no 3104 0.0609955889795979 4537 8407
SGTC_2385 9074692 200 µM -1.55374590339659 0.0835615241462729 no 3105 0.0601225194579114 4524 17046906
SGTC_345 1362-0200 395 µM -1.55801118511987 0.082944235514224 no 3106 0.0596152983423089 4513 1419823
SGTC_2457 5731572 11.68 µM -1.56104665646881 0.0825070235924105 no 3107 0.0592563714284902 4572 2865357
SGTC_749 1000-0129 128 µM -1.56762838773112 0.0815649912096818 no 3108 0.0584839415466495 4545 708470
SGTC_2137 5261020 140 µM -1.56904173391115 0.0813637632283525 no 3109 0.0583191074479032 4518 763655
SGTC_1302 1159-0335 255 µM -1.57149670366115 0.0810151224997615 no 3110 0.0580336597426005 4554 649284
SGTC_2841 9004761 38.96 µM -1.57332724164465 0.0807558946887009 no 3111 0.0578215323189222 4474 2991039
SGTC_399 oxolinic acid 75 µM -1.57674506932558 0.0802735633487789 no 3112 0.0574270977811932 4510 4628 A DNA gyrase inhibitor.
SGTC_1745 st081495 74 µM -1.58165425835733 0.0795845815408787 no 3113 0.0568642601325438 4397 13842402 YBL026W LSM2
SGTC_1413 3910-0535 34.4 µM -1.58203040163909 0.0795319767023629 no 3114 0.0568213151836807 4557 2876951
SGTC_462 ag-879 158 µM -1.58367392418817 0.0793024334447356 no 3115 0.0566339708529299 4553 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_117 lucigenin 22.078 µM -1.58367593121096 0.0793021534399891 no 3116 0.0566337423712502 4511 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.5836761660082 0.0793021206828898 no 3117 0.0566337156417213 4528 688669
SGTC_1591 genipin 88.4 µM -1.58629448599448 0.078937469457702 no 3118 0.0563362612757885 4540 442424 A DNA cross-linking agent.
SGTC_2611 pyromycin 23.93 µM -1.58786958163648 0.0787187198907112 no 3119 0.0561579165735142 4485 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3222 9128301 49.47 µM -1.59060496782204 0.0783399209948386 no 3120 0.0558492528870211 4496 4911358
SGTC_1540 guanosine 70.6 µM -1.59173053017387 0.0781844540450464 no 3121 0.0557226326682403 4489 6802 Guanosine is a purine nucleoside
SGTC_351 caspofungin 25 nM -1.59458043588179 0.0777918607157998 no 3122 0.0554030452076096 4538 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_48 0382-0018 55 µM -1.59627072099873 0.0775597207131793 no 3123 0.0552141820414023 4561 762596
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.59710572970434 0.0774452367555643 no 3124 0.0551210706048818 4561 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2062 5245942 200 µM -1.59800466151817 0.077322132114731 no 3125 0.0550209698324936 4586 1376160
SGTC_3180 9109287 49.47 µM -1.59861693607818 0.0772383690266707 no 3126 0.0549528721218058 4566 18891271
SGTC_548 1436-0017 110 µM -1.59925152617624 0.0771516258019515 no 3127 0.0548823627643577 4570 9677137
SGTC_2247 cerulenin 830 nM -1.60042245310545 0.0769917640948373 no 3128 0.0547524486828477 4566 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1520 flindersine 88 µM -1.60061360593196 0.0769656907290582 no 3129 0.0547312634211995 4559 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3346 9158254 43.5805 µM -1.60145718555286 0.076850706097037 no 3130 0.0546378477950322 4583 17639500
SGTC_2969 9091408 28.7 µM -1.60303336868129 0.0766362135398492 no 3131 0.0544636436032963 4476 4286311
SGTC_928 2764-0428 58.7 µM -1.60305597143889 0.0766331409916318 no 3132 0.0544611486817695 4562 662578
SGTC_2041 5107442 45.335 µM -1.60308623373412 0.0766290273765036 no 3133 0.054457808432143 4559 793005
SGTC_463 ikarugamyin 104 µM -1.6071149358995 0.0760828957104825 no 3134 0.0540145787307872 4690 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1394 3474-0001 65.7 µM -1.60783173921749 0.0759860369766032 no 3135 0.0539360175475296 4536 5017666 YIL048W NEO1
SGTC_754 3474-0146 171 µM -1.60935230679737 0.0757808796882495 no 3136 0.0537696638177559 4531 24762078
SGTC_2007 4011539 71.82 µM -1.61075581397734 0.0755918910447764 no 3137 0.0536164776337754 4510 45595301
SGTC_1518 st038567 90.8 µM -1.61089036578573 0.0755737919103647 no 3138 0.0536018101174928 4502 77966
SGTC_3172 9105863 49.47 µM -1.61117400088137 0.0755356497673442 no 3139 0.0535709014186028 4640 2348785
SGTC_853 0419-0306 21 µM -1.61519816932879 0.0749960744952091 no 3140 0.0531338934424505 4584 762713
SGTC_1744 st037937 38.9 µM -1.61578908706771 0.0749170902310929 no 3141 0.0530699609016845 4569 1016152
SGTC_3085 9117376 49.47 µM -1.61906843951268 0.0744799125436271 no 3142 0.0527162692315247 4608 16480349
SGTC_1234 0326-0494 15.5 µM -1.62199017655721 0.0740920523039771 no 3143 0.0524027257577631 4601 1547813
SGTC_1116 jasmonic acid 1.58368 µM -1.62580648930885 0.0735877635331442 no 3144 0.0519954137280187 4593 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_877 0771-0151 33.1 µM -1.6302284147615 0.0730067357186737 no 3145 0.0515266152918823 4559 6166523
SGTC_2712 st079126 47.7 µM -1.63733649926373 0.072080121913231 no 3146 0.050780089251259 4564 3152970
SGTC_188 3229-0966 278.469 µM -1.64102349758377 0.0716030474690829 no 3147 0.0503962688142536 4613 5722370
SGTC_3330 9141424 71.43 µM -1.64239159366082 0.0714266419784249 no 3148 0.0502544379722783 4570 27261020
SGTC_1575 cyproterone acetate 48 µM -1.64428914283037 0.0711825199692762 no 3149 0.0500582454643095 4547 9880 An androgen receptor antagonist and liver toxin.
SGTC_2889 9059656 51.95 µM -1.64464404450972 0.0711369326336673 no 3150 0.0500216191453801 4609 3949838
SGTC_2826 7992541 19.48 µM -1.6480256119259 0.0707036920108211 no 3151 0.049673707793265 4561 2985066
SGTC_87 0100-0052 35.5 µM -1.64896391317218 0.0705838385460393 no 3152 0.0495775139752075 4584 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1021 4476-0760 85.3 µM -1.64968127423006 0.0704923121506646 no 3153 0.0495040710720925 4585 746768
SGTC_762 1165-0429 115 µM -1.65146401782001 0.0702652512372923 no 3154 0.0493219311007967 4565 5967793
SGTC_1157 4092-0394 27.6 µM -1.65156565760723 0.0702523227522443 no 3155 0.0493115628751521 4610 3659885
SGTC_295 k015-0027 31 µM -1.65455777429061 0.0698725474088299 no 3156 0.04900711742315 4617 3887424
SGTC_1345 1488-0192 31.4 µM -1.65477447740708 0.0698451037746469 no 3157 0.0489851265003965 4606 658348
SGTC_895 0964-0006 13.7 µM -1.65545222015243 0.069759326875778 no 3158 0.0489164003903626 4578 6738897
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.66356247231599 0.0687391528182941 no 3159 0.048099948329878 4514 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2086 5274770 176.623 µM -1.66433215318161 0.0686429368743335 no 3160 0.0480230351578683 4604 689278
SGTC_1180 1193-0155 285 µM -1.66577621385034 0.0684626986264584 no 3161 0.0478789977220571 4625 2921347
SGTC_69 0096-0274 206.684 µM -1.67082011145229 0.0678360160396929 no 3162 0.0473786074324041 4618 6741392
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.67140114662821 0.0677641104180416 no 3163 0.0473212347987785 4546 364106
SGTC_1708 st033234 31.827 µM -1.67556044578257 0.0672510970901257 no 3164 0.0469121609727123 4648 674664
SGTC_972 1319-0219 195 µM -1.67573299201772 0.0672298800592319 no 3165 0.0468952522312212 4569 23903702
SGTC_3165 9101544 49.47 µM -1.67772154172695 0.0669857327511709 no 3166 0.0467007360284736 4573 5002184
SGTC_162 k030-0015 37.8 µM -1.68378467039925 0.0662455548075726 no 3167 0.0461116454303266 4623 1809920 YMR134W ERG29
SGTC_1278 0874-0585 172 µM -1.68572651950862 0.0660098407375168 no 3168 0.0459242432516522 4598 766306
SGTC_1966 st070145 16.1 µM -1.68979904614622 0.0655176024824978 no 3169 0.0455332031877325 4561 3748532
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.69079785629125 0.0653973140314834 no 3170 0.0454377083842252 4533 6708514
SGTC_1027 k015-0025 8.67 µM -1.7000367247937 0.0642927668011659 no 3171 0.0445620089333958 4561 3598955
SGTC_1209 2323-2347 50.3 µM -1.70028520883383 0.0642632609078593 no 3172 0.0445386456329597 4601 5412760
SGTC_1662 st014054 52 µM -1.70111192895911 0.0641651689223058 no 3173 0.0444609856639201 4665 2838777
SGTC_1375 2910-0797 186 µM -1.70725453796262 0.0634399772386721 no 3174 0.0438873760418837 4585 742508
SGTC_1975 st070967 30.8 µM -1.71095312492497 0.0630064116787007 no 3175 0.0435448832088473 4590 261391
SGTC_903 1134-0042 114 µM -1.71760796393428 0.0622321171163497 no 3176 0.0429340733638341 4610 701009
SGTC_2152 5568786 200 µM -1.71952690881202 0.062010230935182 no 3177 0.0427592361173737 4627 5399883
SGTC_688 0527-0193 473 µM -1.72294069426187 0.0616170239670824 no 3178 0.0424496251463521 4631 4007154
SGTC_22 0964-0034 14.468 µM -1.7245889238153 0.0614278756781244 no 3179 0.0423007904716147 4600 138402
SGTC_1553 gossypol 38.6 µM -1.73774738252489 0.0599340529583609 no 3180 0.0411276678678719 4565 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1942 st076330 65.2 µM -1.74007583836718 0.0596727012621663 no 3181 0.0409228511074658 4623 24208414
SGTC_1287 0971-0001 34.6 µM -1.74287410739876 0.0593597989720253 no 3182 0.0406778038961073 4605 4665869
SGTC_529 4076-0302 30.3 µM -1.74526998251811 0.0590929158133253 no 3183 0.0404689422309663 4595 5816522
SGTC_616 4092-0450 108 µM -1.7499581854854 0.0585734074918206 no 3184 0.0400627646400227 4611 787165
SGTC_2867 9039098 71.43 µM -1.75168048346995 0.0583834596113516 no 3185 0.0399143823080721 4589 6463460
SGTC_1043 0916-0009 19.3 µM -1.75318793281713 0.0582176041633829 no 3186 0.0397848768323976 4613 3101130
SGTC_633 0437-0093 97.7 µM -1.77233299048487 0.0561432452145747 no 3187 0.0381696489927939 4564 2831118
SGTC_2770 toltrazuril 17.5 µM -1.77287194751212 0.056085704105631 no 3188 0.0381249640060985 4544 68591 Kills coccidiodes.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.77730970879736 0.0556136781472191 no 3189 0.0377586485658076 4576 6857784
SGTC_1065 prochlorperazine maleate 2.48 µM -1.78041720344864 0.0552850177037899 no 3190 0.0375038541921561 4654 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_367 0335-0881 7.1 µM -1.78159489187527 0.0551608624675351 no 3191 0.0374076590213292 4540 23828853
SGTC_2432 5630864 12.22 µM -1.78388061281256 0.0549205239759637 no 3192 0.0372215334135632 4613 5714970
SGTC_532 1548-0774 215 µM -1.78622369327415 0.0546750140050912 no 3193 0.0370315231381947 4658 5932993
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.78685847131542 0.0546086510228337 no 3194 0.0369801830249765 4644 688664
SGTC_3097 9117246 49.47 µM -1.79351280719812 0.0539167997127522 no 3195 0.0364454823219783 4638 16423892
SGTC_2294 7971431 200 µM -1.796364415897 0.0536224502525659 no 3196 0.036218289639315 4610 5741572
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.79742832187371 0.0535129580957439 no 3197 0.0361338239346611 4607 229346 A bile salt which induces apoptosis.
SGTC_2885 9057732 51.95 µM -1.79888642594577 0.0533631847763976 no 3198 0.0360183241132193 4613 6471414
SGTC_921 1561-0023 372 µM -1.7989753580797 0.0533540606186116 no 3199 0.0360112893866038 4599 24050882
SGTC_781 4335-2806 94.4 µM -1.7996853052438 0.0532812665938032 no 3200 0.0359551713514522 4649 845254
SGTC_979 1426-2828 121 µM -1.80590177873039 0.0526472217920095 no 3201 0.0354668416118019 4664 747872
SGTC_2216 7189485 200 µM -1.8174582279516 0.0514844537686792 no 3202 0.0345734894303946 4664 731273
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.82338685101673 0.0508959137061629 no 3203 0.0341224101954192 4610 1377
SGTC_3191 9110352 49.47 µM -1.82574793465948 0.050663023179658 no 3204 0.0339441195807591 4593 17122424
SGTC_215 1287-0124 461.5 µM -1.82615105991015 0.0506233450203703 no 3205 0.0339137554194498 4691 5560863
SGTC_886 0866-0150 153 µM -1.82725093482283 0.050515214196348 no 3206 0.0338310243637199 4662 271463
SGTC_984 1492-0255 2.91 µM -1.83223004639901 0.0500280081605006 no 3207 0.0334585770767054 4602 1585198
SGTC_3228 9131799 49.47 µM -1.83325891129725 0.0499278023688624 no 3208 0.033382038350209 4669 17015818
SGTC_2260 7964312 200 µM -1.83964028522385 0.0493098621286655 no 3209 0.0329105329142555 4651 231951
SGTC_1058 3448-5425 97.3 µM -1.8441336448699 0.0488784229107569 no 3210 0.0325818328634377 4598 7279705
SGTC_237 nikkomycin 200 µM -1.84639487071837 0.0486624504348085 no 3211 0.0324174457252542 4652 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1504 k297-0033 30 µM -1.85949876908812 0.0474258597317157 no 3212 0.0314782367845447 4575 4388117
SGTC_571 k831-0106 44.2 µM -1.86213482646112 0.0471801680510401 no 3213 0.0312920440651785 4551 4783639
SGTC_1300 1094-0077 113 µM -1.86406143159792 0.0470012464865963 no 3214 0.0311565389667555 4633 5532636
SGTC_1726 st035556 14.5795 µM -1.86681348353773 0.0467466107867417 no 3215 0.0309638194467484 4662 5919439
SGTC_335 4077-0256 27.6 µM -1.87606967641902 0.0458982862003932 no 3216 0.0303228564594335 4566 3121989
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.87627114120799 0.0458799605462191 no 3217 0.0303090288345948 4658 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2992 9074591 71.4286 µM -1.87956849260589 0.0455808614114869 no 3218 0.0300834553430905 4600 17741321
SGTC_2785 7756463 72.73 µM -1.88085009619365 0.0454650324753486 no 3219 0.0299961566475322 4631 2201551
SGTC_1159 4092-0538 61.2 µM -1.88251007730787 0.0453153584623178 no 3220 0.0298833964646207 4675 717301
SGTC_882 0843-0131 351 µM -1.88595494960218 0.0450060125910129 no 3221 0.0296505128645197 4672 5425421
SGTC_324 1315-0088 19.6 µM -1.89180280452652 0.0444847750558806 no 3222 0.0292586297519967 4650 6787421
SGTC_3312 9133330 71.43 µM -1.89694565073437 0.0440304066582331 no 3223 0.0289175557717743 4666 17617324
SGTC_2088 5278280 127.392 µM -1.89738012147968 0.0439921933973661 no 3224 0.0288888936459973 4673 791502
SGTC_554 4483-2211 187 µM -1.90061818322791 0.0437082359985621 no 3225 0.0286760210344406 4680 747107
SGTC_2145 5634607 200 µM -1.90255515588692 0.0435390839506163 no 3226 0.0285493076788359 4666 308662
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.90407590164661 0.0434066507712635 no 3227 0.0284501498468247 4636 756377
SGTC_397 arbidol 50 µM -1.90730672664412 0.04312637577129 no 3228 0.0282404398267314 4675 131410 A RNA synthesis inhibitor.
SGTC_2019 4016004 108 µM -1.90740859302376 0.0431175626613599 no 3229 0.0282338487495136 4649 45595336
SGTC_1827 berberine 7.24 µM -1.90944993522197 0.0429412596173066 no 3230 0.0281020371524249 4590 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2759 disulfiram 3.38 µM -1.91096544947363 0.0428107474797775 no 3231 0.0280045105577484 4568 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2700 st077718 96.8 µM -1.91437411694432 0.0425183732950809 no 3232 0.027786185154175 4635 904970
SGTC_2112 5488546 200 µM -1.91675902971735 0.0423147721271405 no 3233 0.0276342760595148 4639 600757
SGTC_2028 5153890 36.43 µM -1.91781642746547 0.0422247542945092 no 3234 0.0275671460158419 4645 2830968 YPR165W RHO1
SGTC_404 fumagillin 50 µM -1.92296158105214 0.0417889487411834 no 3235 0.0272424374799793 4677 12015870 A methionine aminopeptidase binder.
SGTC_1956 st077085 54 µM -1.92711308407 0.0414399690207497 no 3236 0.0269827692533799 4668 24208685
SGTC_1980 st071811 45.7 µM -1.93013915712046 0.0411870852252197 no 3237 0.0267947989136635 4704 4974850
SGTC_2161 5662504 8.5105 µM -1.93231440973711 0.0410060771375904 no 3238 0.0266603554665848 4674 2859334
SGTC_3163 9099914 49.47 µM -1.93300400953951 0.0409488287264649 no 3239 0.0266178519360666 4734 16268368
SGTC_2047 4141938 200 µM -1.933234133632 0.0409297389795898 no 3240 0.0266036808244901 4683 3807862
SGTC_515 4092-1064 102 µM -1.93409328152012 0.0408585328788506 no 3241 0.0265508299132426 4625 717353
SGTC_2484 5809818 12.04 µM -1.93528519481845 0.0407599136715142 no 3242 0.0264776540584709 4635 2870548
SGTC_227 fluconazole 33.516 µM -1.93649446522987 0.0406600558098531 no 3243 0.0264035848868539 4656 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1713 st033146 12.748 µM -1.93847754998013 0.0404967285743883 no 3244 0.0262824935913712 4632 674619
SGTC_71 0417-1750 47.813 µM -1.95784994112896 0.0389290719396173 no 3245 0.025123811649094 4624 6811472
SGTC_36 0335-0881 14.2 µM -1.95825953455557 0.0388964679188502 no 3246 0.0250997832281984 4598 23828853
SGTC_1256 0570-0116 285 µM -1.96133901285045 0.0386520500650182 no 3247 0.0249197445926976 4666 410638
SGTC_1085 doxorubicin 7.67 µM -1.97129542504131 0.0378703619330808 no 3248 0.0243450471778289 4687 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3325 9138760 55.175 µM -1.97482681490828 0.0375962273282932 no 3249 0.0241439024514097 4631 43844959
SGTC_1025 k007-0731 70 µM -1.99084028412732 0.0363733953290228 no 3250 0.0232492245021974 4661 6256118
SGTC_566 0958-0068 16.5 µM -1.99355382043742 0.0361694437871529 no 3251 0.0231004181509242 4607 6815365
SGTC_1609 st001574 46.4 µM -1.99510216387944 0.0360534892591664 no 3252 0.0230158692069455 4666 3960012
SGTC_2927 9011802 47.9 µM -2.00071829142427 0.0356354530323958 no 3253 0.0227113785461794 4641 43912568
SGTC_2894 9048625 32.47 µM -2.01569025722406 0.0345403982718045 no 3254 0.0219161875167249 4685 4092861
SGTC_1098 clofazimine 15.1 µM -2.0164020935274 0.0344890304509854 no 3255 0.021878973390932 4716 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2844 9010103 25.97 µM -2.02537038641623 0.0338472170357428 no 3256 0.0214146729577317 4640 2480525
SGTC_878 0828-0289 13.7 µM -2.02827289112944 0.0336416167304059 no 3257 0.0212662020669303 4678 745350 YLR208W SEC13
SGTC_1870 st057514 26.5 µM -2.03233817876543 0.0333553791269286 no 3258 0.0210597159638424 4689 5393161
SGTC_3110 9122132 49.47 µM -2.03938778568236 0.0328637707263124 no 3259 0.0207056702375213 4702 918317
SGTC_3167 9103034 49.47 µM -2.04060862240521 0.0327792447147659 no 3260 0.0206448722269277 4747 5127859
SGTC_2146 5545642 200 µM -2.04061083015442 0.0327790920212638 no 3261 0.0206447624175145 4676 825326
SGTC_1084 voriconazole 435 nM -2.04741854649316 0.0323110342438491 no 3262 0.0203085034552667 4713 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3310 9130229 44.1445 µM -2.04922428106413 0.0321878124958544 no 3263 0.0202200944046988 4683 7761258
SGTC_1998 st075797 76.8 µM -2.05255795106757 0.0319613449007849 no 3264 0.020057734607046 4692 24208315
SGTC_3044 9093193 49.47 µM -2.05634505519948 0.0317056721650672 no 3265 0.0198746341721504 4678 25236277
SGTC_2656 pseudo-anisatin 100 µM -2.06800940097056 0.0309287941619427 no 3266 0.0193195695497921 4751 6708809 A neurotoxin.
SGTC_2060 5238662 140 µM -2.06861812142913 0.0308886880686513 no 3267 0.0192909680328821 4668 790130
SGTC_3220 9131269 49.47 µM -2.08154197064436 0.030047297114715 no 3268 0.0186921633127925 4712 17722206
SGTC_1168 k815-0004 80.5 µM -2.08175063414986 0.0300338698058747 no 3269 0.0186826265057138 4690 642433
SGTC_975 1335-0046 28.5 µM -2.09451087491032 0.0292221652805879 no 3270 0.0181072476721383 4701 16486740
SGTC_392 N-ethylmaleimide 8.33 µM -2.11551254707711 0.0279259245269054 no 3271 0.017193143344236 4703 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1077 5-fluorocytosine 377 nM -2.12678365754157 0.0272502438157295 no 3272 0.0167190313881468 4740 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2100 5377183 190 µM -2.13100702973191 0.0270005986396657 no 3273 0.0165442815272663 4727 2844202
SGTC_1408 3909-7976 48.8 µM -2.14193232220915 0.0263636434229688 no 3274 0.0160994642223229 4733 24152374
SGTC_1342 1486-1464 234 µM -2.14346613341186 0.0262752342446002 no 3275 0.0160378438381573 4733 3253938
SGTC_965 1291-5240 308 µM -2.15362517772802 0.0256959015128786 no 3276 0.0156347890700355 4701 2834598
SGTC_2603 homopterocarpin 100 µM -2.1688327665726 0.0248486782924525 no 3277 0.0150476913067406 4693 101795 A weak amylase inhibitor.
SGTC_1881 5652484 16 µM -2.17204572118859 0.0246727130444657 no 3278 0.0149261072265929 4701 2255129
SGTC_1927 st060202 13.8 µM -2.17573626912716 0.0244718825645967 no 3279 0.0147874932711035 4676 688887
SGTC_25 0118-0223 35.662 µM -2.18281422174232 0.0240905562833133 no 3280 0.014524746962275 4706 5333628
SGTC_1844 rapamycin 4 nM -2.20142830266249 0.0231114775237451 no 3281 0.0138528585988351 4568 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3008 9078912 71.4286 µM -2.22873600747458 0.02173590194623 no 3282 0.0129157374825581 4728 16648731
SGTC_2854 9024559 71.43 µM -2.23930301694068 0.0212224925230486 no 3283 0.0125681033595314 4705 3163529
SGTC_3046 9092212 49.47 µM -2.26440739025224 0.0200437612752402 no 3284 0.0117745349282822 4756 25236637
SGTC_811 0416-0114 265 µM -2.26602470157468 0.0199697658703236 no 3285 0.011724935444719 4733 6612453
SGTC_256 clotrimazole 625 nM -2.26762220702866 0.0198969042720903 no 3286 0.0116761214904223 4688 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_396 dithiazanine 1.25 µM -2.27476420755286 0.0195739130472133 no 3287 0.0114600392206536 4721 10578 An antihelmenthic.
SGTC_231 b-estradiol 524 µM -2.280539948193 0.0193159765288056 no 3288 0.0112878421517886 4744 450 A steroid.
SGTC_1983 st071813 46.9 µM -2.28269217130868 0.0192206027397247 no 3289 0.0112242536318043 4760 11838595
SGTC_390 dec-rvkr-cmk 16.7 µM -2.30560348875237 0.0182298816279618 no 3290 0.0105663990864487 4746 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_455 paf C-16 10 µM -2.31131165894693 0.0179899345769433 no 3291 0.0104078232481733 4716 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2031 5180455 200 µM -2.32242216922513 0.0175306119310069 no 3292 0.0101051073926413 4747 29949
SGTC_244 nsc-207895 1.295 µM -2.32344043793829 0.0174890207177819 no 3293 0.0100777519403843 4684 42640
SGTC_1243 0416-0003 5.65 µM -2.33431820932023 0.0170499500291727 no 3294 0.00978953297504396 4715 2141977
SGTC_3022 9087993 49.47 µM -2.3381972207108 0.0168956731869745 no 3295 0.00968850981375866 4781 17173644
SGTC_1139 k015-0024 46.9 µM -2.34598058889734 0.0165897095523934 no 3296 0.00948854787903022 4754 2766652
SGTC_265 mycophenolic acid 32.932 µM -2.35090199446988 0.016398706532048 no 3297 0.00936398293392638 4753 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2328 6201408 200 µM -2.35336690498188 0.0163037515260647 no 3298 0.00930213336297983 4707 2890418
SGTC_872 0588-0139 234 µM -2.35389182806098 0.0162835910050573 no 3299 0.00928900824683853 4735 2047100
SGTC_3213 9129884 49.47 µM -2.38239806620195 0.0152203648603031 no 3300 0.00860014659307765 4712 17190742
SGTC_2763 lisinopril 49.32 µM -2.38914162004513 0.0149777501849393 no 3301 0.00844389557157241 4706 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_394 menadione 8.33 µM -2.39390741996314 0.0148083012031262 no 3302 0.00833497794861253 4742 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1466 k213-0079 57.5 µM -2.39846465610645 0.0146478123968591 no 3303 0.00823198264250562 4764 3657981
SGTC_1610 st001799 48.1 µM -2.40124034569192 0.014550798145616 no 3304 0.0081698002751728 4721 621897
SGTC_3192 9110362 49.47 µM -2.41631275303771 0.0140335952899301 no 3305 0.00783929397789684 4738 16649480
SGTC_168 3970-0862 530.542 µM -2.41848099983606 0.0139605122598662 no 3306 0.0077927297418585 4706 3135186
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.44042883604225 0.0132390212818509 no 3307 0.00733491798324267 4761 368090
SGTC_2081 5214970 32.255 µM -2.46250632883375 0.012545996422924 no 3308 0.00689848689352407 4736 2063512
SGTC_1247 0448-0043 5.84 µM -2.46537627765698 0.0124582554274245 no 3309 0.00684347170450062 4726 3089013 YGL099W LSG1
SGTC_1710 st031758 61.5 µM -2.46922708648427 0.0123413624008223 no 3310 0.00677026300165197 4774 5394341
SGTC_2271 7849410 118.62 µM -2.50288465951882 0.0113594879054272 no 3311 0.00615928410110766 4717 972430
SGTC_701 4424-0219 185 µM -2.51611085817797 0.0109926437035601 no 3312 0.005932892676823 4764 2911779
SGTC_1075 aripiprazole 15.2 µM -2.51911744835943 0.0109107048021176 no 3313 0.00588247031061299 4784 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2438 5259590 200 µM -2.54219437377911 0.010299293276948 no 3314 0.00550794469349148 4770 1201127
SGTC_70 0141-0289 43.283 µM -2.57659879795143 0.00944326859478821 no 3315 0.00498888432952411 4753 352408
SGTC_134 0269-0018 6.916 µM -2.59148331859124 0.00909264000414871 no 3316 0.00477815872241698 4740 4378915
SGTC_1226 3909-7979 35.4 µM -2.60997302282209 0.00867300034547429 no 3317 0.00452746815346516 4754 6615510
SGTC_2051 5263410 176 µM -2.6196834610125 0.00845949172535193 no 3318 0.0044005709012603 4741 227584
SGTC_2383 9036125 200 µM -2.6273347413416 0.00829452232728534 no 3319 0.00430283156602425 4764 79580
SGTC_2790 5423970 71.43 µM -2.63506687567831 0.00813068652170961 no 3320 0.00420603538039442 4754 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1611 st001856 99.4 µM -2.63519327840933 0.00812803197437164 no 3321 0.00420446929473292 4777 647478
SGTC_3188 9110789 49.47 µM -2.66215235932021 0.00757898600601825 no 3322 0.00388213627228035 4759 849217
SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.68996358035043 0.00704707230322792 no 3323 0.00357299086561241 4765 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2388 9080168 200 µM -2.74554197490698 0.00608187153675713 no 3324 0.00302055194531742 4782 15943073
SGTC_796 1234-0020 70.7 µM -2.77875372838252 0.00556274900521484 no 3325 0.00272839391656255 4764 46495034
SGTC_963 1269-2853 151 µM -2.79590441563555 0.00531039989138921 no 3326 0.00258773523254449 4780 3668223
SGTC_2373 9071805 200 µM -2.90946516655445 0.00388146089176393 no 3327 0.00181023864827595 4794 10149009
SGTC_2939 9044578 71.43 µM -2.9258201365894 0.00370691143163365 no 3328 0.00171774749674608 4757 2653634
SGTC_3053 9095903 49.47 µM -2.94859587348782 0.00347556582921132 no 3329 0.00159610553926524 4807 17174018
SGTC_960 1222-0186 7.7 µM -3.04096905251077 0.00266453775644647 no 3330 0.00117909033858596 4773 3126296
SGTC_2155 5570423 76 µM -3.0613598411225 0.00251036398662579 no 3331 0.00110167060404047 4784 797402
SGTC_1692 fluoroquinolonic acid 71 µM -3.06371930158222 0.00249305505594038 no 3332 0.0010930195830246 4798 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1992 st073643 23.3 µM -3.14698483151283 0.001947219228479 no 3333 0.00082481759702035 4795 3161292
SGTC_260 nsc-65238 3.989 µM -3.1527490375359 0.00191378725032694 no 3334 0.000808703964324152 4796 3246252
SGTC_1324 1418-0026 34.4 µM -3.1535763989684 0.00190903165237761 no 3335 0.000806415031260303 4803 1372513
SGTC_2405 ticlatone 3.52 µM -3.20636016423736 0.00162693376447043 no 3336 0.00067212810918597 4718 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2903 5923464 63.88 µM -3.21387150815616 0.00159003413094233 no 3337 0.000654791313184062 4791 2876576
SGTC_1155 4088-0394 48.2 µM -3.23850942000228 0.00147429039071527 no 3338 0.000600780264962213 4802 2326248
SGTC_977 1348-1378 135 µM -3.24743641618724 0.00143428777960274 no 3339 0.000582248400811194 4786 X977
SGTC_2911 7942208 15.64 µM -3.31224239934767 0.00117232429560217 no 3340 0.000462756581828173 4797 1243384
SGTC_2149 5554786 194.827 µM -3.33555603001229 0.00108935102532782 no 3341 0.000425644985371501 4799 745063 YPR165W RHO1
SGTC_2912 7964298 10.93 µM -3.33990371688761 0.00107448648277222 no 3342 0.000419037201496144 4793 2975850
SGTC_1087 pterostilbene 9.05 µM -3.37513198630407 0.00096072902417933 yes 3343 0.000368901484371039 4799 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2059 5238311 157 µM -3.38503014471386 0.000930818400342953 yes 3344 0.000355852190560635 4791 703021
SGTC_1761 st044296 37 µM -3.45079299260088 0.000752842428816979 yes 3345 0.000279471052760515 4803 1826700
SGTC_2499 avocadenofuran 51.48 µM -3.45789425586287 0.000735628638600382 yes 3346 0.000272207511608705 4799 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -3.51650980505482 0.000606796179856974 yes 3347 0.00021863025419394 4795 279621
SGTC_2855 9016525 58.44 µM -3.65981990173564 0.000374416076377699 yes 3348 0.000126196287695955 4795 43811474
SGTC_1458 k015-0034 6.33 µM -3.66195151250386 0.000371688530949925 yes 3349 0.000125150620719685 4799 3598957
SGTC_2830 7992007 71.43 µM -3.73262182619378 0.000291050482467327 yes 3350 9.47484969962925e-05 4777 1952075
SGTC_261 5-fluorouridine 15.376 µM -3.82948962560902 0.000206739378788799 yes 3351 6.42046480645047e-05 4807 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_692 k241-0027 77.8 µM -3.87470999458869 0.000175753465969019 yes 3352 5.33758767981048e-05 4808 3600480
SGTC_2850 9015429 58.44 µM -4.01096612071129 0.000106632105270234 yes 3353 3.02353940917884e-05 4803 6457570
SGTC_2937 9044753 11.33 µM -4.02328205473913 0.000101844276910157 yes 3354 2.86963472089325e-05 4800 6465530 YGL099W LSG1
SGTC_1142 3253-1408 9.78 µM -4.03875177412602 9.61163588857902e-05 yes 3355 2.68681970083709e-05 4794 256655
SGTC_421 streptovitacin 30 mM -6.02944173657769 1.01426234977153e-08 yes 3356 8.22635081854322e-10 4807 91467 include heat shock