SGTCid condition conc unit ARP7|YPR034W.score ARP7|YPR034W.strain.pval ARP7|YPR034W.strain.significant ARP7|YPR034W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2567 aureobasidin a 60 nM 25.4387809059172 1.0759782804007e-74 yes 1 4.69796108207864e-143 4 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3304 9125678 46.087 µM 23.3313417525855 3.32246670691479e-63 yes 2 1.06597764536715e-120 6 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2109 5483026 200 µM 21.6286186253864 1.22008896142846e-54 yes 3 4.83168645697724e-104 1 759335 SGTC_2111 5486399 200 µM 17.3493871272556 6.03023762624904e-36 yes 4 9.96798711055819e-68 3 689674 SGTC_1374 2889-5571 141 µM 17.1349512051794 4.07974991156677e-35 yes 5 4.07106038024659e-66 1 2853281 SGTC_2248 tofa 1.1 µM 15.2214822090186 3.71835939795053e-28 yes 6 1.2734729970458e-52 3 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_928 2764-0428 58.7 µM 13.8692941828766 1.0042414681514e-23 yes 7 4.861440938637e-44 2 662578 SGTC_2396 5342950 42.78 µM 13.310602923682 5.19168167055734e-22 yes 8 1.00427154063861e-40 3 1886677 SGTC_58 0957-0393 9 µM 11.8889569574796 5.83432333160894e-18 yes 9 6.75414900427944e-33 5 6997992 SGTC_2186 6124449 200 µM 11.8588055069306 7.03226468478978e-18 yes 10 9.68594852314757e-33 5 3834182 YLR033W RSC58 SGTC_2225 6654152 15.4 µM 11.7651003583271 1.25279729727345e-17 yes 11 2.95280395747977e-32 5 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2378 9074213 121.43 µM 11.7192168267077 1.65950191378121e-17 yes 12 5.08034809705142e-32 3 657714 SGTC_165 k038-0023 64.381 µM 10.9919740441656 1.24040734219376e-15 yes 13 2.08844571425324e-28 3 46368543 SGTC_2912 7964298 10.93 µM 10.1285075218546 1.47151513216203e-13 yes 14 2.06451724188027e-24 14 2975850 SGTC_1493 4348-0038 111 µM 10.1053072381937 1.66436111287825e-13 yes 15 2.61656396229687e-24 2 800424 SGTC_2612 dictamnine 15.46 µM 9.81391283833718 7.63802814023942e-13 yes 16 4.9044784823835e-23 8 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3037 9091026 49.47 µM 9.77893176976904 9.1448071415282e-13 yes 17 6.93331516363492e-23 7 25236398 YIL048W NEO1 SGTC_227 fluconazole 33.516 µM 9.4487372177218 4.85411644978682e-12 yes 18 1.71471434003989e-21 13 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3321 9137793 26.8275 µM 9.18936117892994 1.7334101855403e-11 yes 19 1.97590599467475e-20 3 4904192 SGTC_673 1082-0474 110 µM 9.18644423577727 1.75806416825048e-11 yes 20 2.03020744969119e-20 16 3098046 SGTC_2344 7990960 76.95 µM 9.15654826328536 2.03137173813862e-11 yes 21 2.67919179991401e-20 9 140813 SGTC_829 1635-0120 117 µM 9.14105542564453 2.18894025468446e-11 yes 22 3.09228800875275e-20 8 285054 SGTC_2679 rapamycin 1 nM 9.06410887879531 3.16663739931633e-11 yes 23 6.28134498261908e-20 12 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1679 SEC14.276 6.7 µM 9.00217170920056 4.25349352937425e-11 yes 24 1.10648050209752e-19 9 1005053 YMR079W SEC14 SGTC_1652 st011932 78 µM 8.96444059752486 5.0863008228612e-11 yes 25 1.55929899029689e-19 13 1551076 SGTC_2584 androsterone 48.74 µM 8.78072668438821 1.20251147844541e-10 yes 26 8.12109026349658e-19 3 2754130 A steroid. SGTC_3288 9119690 36.221 µM 8.66256178522545 2.07285215451873e-10 yes 27 2.30639416951986e-18 6 17595618 YKL019W RAM2 SGTC_64 000l-0018 272.079 µM 8.31072474289884 1.00631352186485e-09 yes 28 4.75596662118006e-17 16 6811119 SGTC_2575 plumbagin 510 nM 8.14037750456543 2.11496352716042e-09 yes 29 1.97023664277573e-16 4 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2747 doxorubicin 7.63 µM 8.0943604131211 2.57846980536269e-09 yes 30 2.87830059920424e-16 2 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_61 0978-8327 98.565 µM 8.07472505655582 2.80506947609702e-09 yes 31 3.38144281191363e-16 2 6150059 YHR072W ERG7 SGTC_1525 8-methoxypsoralen 92.5 µM 7.94694821750576 4.83012552512507e-09 yes 32 9.55811352664622e-16 3 4114 Related to psoralen; DNA damaging agent. SGTC_3120 9124077 49.47 µM 7.90576372596563 5.74482202990134e-09 yes 33 1.33147924301121e-15 8 18774327 YGL155W CDC43 SGTC_682 0kpi-0099 17 µM 7.89417599805702 6.0311765868854e-09 yes 34 1.46119766274491e-15 8 1714895 YML126C ERG13 SGTC_2041 5107442 45.335 µM 7.86816435052616 6.72539515754258e-09 yes 35 1.79941302499886e-15 11 793005 SGTC_2336 9001819 198.65 µM 7.86056327384756 6.94251293399707e-09 yes 36 1.91204945073275e-15 18 2989602 SGTC_2229 7354935 190 µM 7.77816591587152 9.77907522925754e-09 yes 37 3.67917624622148e-15 5 318112 SGTC_783 0848-0141 92.7 µM 7.71570409508867 1.26503925955623e-08 yes 38 6.01580795903059e-15 3 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1044 1222-0021 1.78 µM 7.6099928682449 1.94717673755339e-08 yes 39 1.37055523831337e-14 8 4306703 SGTC_1754 st042065 16.137 µM 7.58210840107252 2.17976306163572e-08 yes 40 1.6999201031335e-14 8 1126236 YIL048W NEO1 SGTC_964 1287-0107 19.4 µM 7.55650266187486 2.41691123401597e-08 yes 41 2.07025715644827e-14 3 51516812 YPR165W RHO1 SGTC_1098 clofazimine 15.1 µM 7.49108072886804 3.14204159695061e-08 yes 42 3.41543916532837e-14 6 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1266 0828-0227 32.9 µM 7.47302823188909 3.37670366467544e-08 yes 43 3.91850126170656e-14 2 3913820 SGTC_69 0096-0274 206.684 µM 7.45886020825956 3.57267714554614e-08 yes 44 4.36370703304683e-14 11 6741392 SGTC_2346 9031566 143.75 µM 7.42156466043138 4.14268636717199e-08 yes 45 5.78723609395838e-14 3 4771086 SGTC_1229 0139-0193 12.2 µM 7.40216002006452 4.47313668996955e-08 yes 46 6.69934497687161e-14 4 3090752 SGTC_22 0964-0034 14.468 µM 7.34405999625018 5.62239415882386e-08 yes 47 1.0360508352801e-13 7 138402 SGTC_152 4469-0003 551.229 µM 7.27578155414046 7.34003207863343e-08 yes 48 1.72210268345681e-13 1 697280 SGTC_768 0384-0033 77.3 µM 7.1294380300879 1.28962184883461e-07 yes 49 5.03897693260703e-13 6 3965305 YMR134W ERG29 SGTC_2348 9022543 33.42 µM 7.09482572214283 1.47122221988836e-07 yes 50 6.4757295856815e-13 12 3162678 YDL140C RPO21 SGTC_2736 butenafine 14.65 µM 7.03591062669941 1.83854809842243e-07 yes 51 9.89819014170172e-13 2 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_62 0180-0423 3.232 µM 7.02912860124759 1.88612226931025e-07 yes 52 1.03913681971906e-12 2 30102 YGL099W LSG1 SGTC_1213 1315-0166 115 µM 7.01552914319477 1.98512403830937e-07 yes 53 1.14540154646941e-12 1 768401 SGTC_158 k038-0087 26.446 µM 6.97192748663563 2.33750562069661e-07 yes 54 1.56313847295942e-12 9 X158 SGTC_168 3970-0862 530.542 µM 6.86515989811218 3.47375631786779e-07 yes 55 3.32084087395531e-12 14 3135186 SGTC_1915 st067105 30.6 µM 6.74104276431955 5.46670069560487e-07 yes 56 7.86269553130353e-12 17 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_642 0335-0876 158 µM 6.7247100688894 5.79952937598659e-07 yes 57 8.79712093664193e-12 3 6812350 SGTC_643 k048-0106 28.4 µM 6.65646476895521 7.41350636493427e-07 yes 58 1.40246164543716e-11 8 6763920 SGTC_632 0781-2353 4.65 µM 6.61518494902137 8.59086955126361e-07 yes 59 1.85543749404712e-11 3 6811515 YHR007C ERG11 SGTC_56 0957-0365 83.25 µM 6.51573385278571 1.22111919799417e-06 yes 60 3.61675663097748e-11 1 6752360 SGTC_67 0335-0847 266 µM 6.4603498844866 1.48214041480292e-06 yes 61 5.22305861737401e-11 8 4552207 YOR254C SEC63 SGTC_2400 5203494 178.7 µM 6.40936492424341 1.76912215796512e-06 yes 62 7.30635234696872e-11 5 6777674 SGTC_871 0574-0004 149 µM 6.32812136113929 2.33936014483976e-06 yes 63 1.24081966492552e-10 15 9551173 SGTC_138 0850-0259 40.9225 µM 6.25794310087829 2.97012031966626e-06 yes 64 1.95044040124241e-10 31 6813004 SGTC_2257 7960413 200 µM 6.257168434466 2.97791716824223e-06 yes 65 1.9601497429046e-10 9 2974689 YIL048W NEO1 SGTC_2890 9046729 58.44 µM 6.24864794359159 3.06497682963959e-06 yes 66 2.07010474212423e-10 5 903329 SGTC_2619 obliquin 87.91 µM 6.24674867238195 3.08471227179947e-06 yes 67 2.09542288575212e-10 13 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2322 7413319 38.22 µM 6.1716295664703 3.9705018950867e-06 yes 68 3.3794854650499e-10 10 1840400 SGTC_181 1447-1644 8.07 µM 6.15998941301605 4.12786548758323e-06 yes 69 3.63749038715925e-10 7 534600 SGTC_1547 harmine 94.2 µM 6.15188742815632 4.24089648762139e-06 yes 70 3.82831093840291e-10 4 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_624 k048-0052 28 µM 6.12095620613715 4.70022903649574e-06 yes 71 4.65077343426217e-10 2 6835531 SGTC_221 trifluoperazine 10.304 µM 6.045612643613 6.02633119187571e-06 yes 72 7.44216569807953e-10 15 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1800 st050079 29.0735 µM 6.02742223051293 6.396323504446e-06 yes 73 8.32976843003919e-10 8 3645560 SGTC_1137 ixabepilone 100 µM 5.91838242611319 9.11110433009374e-06 yes 74 1.62561647530722e-09 2 154225 A novel microtubule stabilizer. SGTC_2647 atorvastatin 60.16 µM 5.84634313514981 1.1473293408714e-05 yes 75 2.51248487212396e-09 1 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_86 0417-1630 471.922 µM 5.83674460146248 1.18289003495907e-05 yes 76 2.66152974473224e-09 12 3634867 SGTC_2534 helenine 20.12 µM 5.81075132907313 1.28453104791582e-05 yes 77 3.1096543473123e-09 13 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3152 9099253 49.47 µM 5.79291721665601 1.35901494666718e-05 yes 78 3.45871045741411e-09 14 25236131 SGTC_1875 nocodazole 6 µM 5.68674934821316 1.89476229549019e-05 yes 79 6.47401403143698e-09 18 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2361 9034121 116 µM 5.67280091984846 1.9785139055379e-05 yes 80 7.02407259573752e-09 12 6496917 SGTC_1050 3232-1156 69.3 µM 5.66529605675182 2.02501774433499e-05 yes 81 7.33854496589135e-09 8 700529 SGTC_145 3737-0113 38.366 µM 5.61715265223603 2.3489285368845e-05 yes 82 9.70649520186327e-09 21 6849351 SGTC_557 1315-0110 16.2 µM 5.61352756439371 2.37521078544926e-05 yes 83 9.9121502570593e-09 3 6833801 SGTC_1707 st032323 6.317 µM 5.55692511931126 2.82353731474284e-05 yes 84 1.37284238926236e-08 18 3132057 YMR211W DML1 SGTC_2671 danthron 100 µM 5.55210918729653 2.86517541994697e-05 yes 85 1.41121600939685e-08 9 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2544 sphondin 68.51 µM 5.52374506951322 3.12245367271896e-05 yes 86 1.65924433769759e-08 19 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1086 cerivastatin 2.18 µM 5.52016844863085 3.15640669520905e-05 yes 87 1.69337421516463e-08 1 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1722 st034304 3.6505 µM 5.4654797191998 3.72113000394053e-05 yes 88 2.30828287292473e-08 5 4036148 YLR033W RSC58 SGTC_55 0767-0285 6.563 µM 5.42336749572929 4.21975209072488e-05 yes 89 2.92432872251788e-08 3 3116166 SGTC_2387 9077560 195.08 µM 5.36146478640101 5.06853930806011e-05 yes 90 4.12749080177873e-08 6 5303272 SGTC_2416 tofa 880 nM 5.33704204284752 5.4458200538041e-05 yes 91 4.72375697184131e-08 2 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1749 st037932 54.2 µM 5.33287555538706 5.51277221879894e-05 yes 92 4.83347818526968e-08 1 594497 SGTC_3065 9113888 49.47 µM 5.31909325547462 5.73981802796816e-05 yes 93 5.21428378313754e-08 3 16648368 SGTC_3020 9089140 49.47 µM 5.29963382331138 6.07544308303238e-05 yes 94 5.80175805717994e-08 5 17217859 SGTC_1815 st051655 58.2 µM 5.28400040254622 6.35839412094973e-05 yes 95 6.31964863566664e-08 6 5984156 SGTC_885 0865-0106 16.8 µM 5.28065186215255 6.42059362450712e-05 yes 96 6.43625392581541e-08 8 2793380 SGTC_546 peri-Naphthalide 147 µM 5.25757362756591 6.86512599754014e-05 yes 97 7.29842304553702e-08 12 223824 A penicillin ester. SGTC_1511 0906-3109 28.5 µM 5.2203636154274 7.64342440984168e-05 yes 98 8.92860862699121e-08 3 2882180 SGTC_157 1348-1695 65.819 µM 5.13664388609433 9.70858249196051e-05 yes 99 1.39844113293896e-07 23 5380510 SGTC_203 k066-0004 30.888 µM 5.11547590410904 0.000103082325141463 yes 100 1.56475449139153e-07 7 6795412 SGTC_1844 rapamycin 4 nM 5.10965846519927 0.000104790246522775 yes 101 1.61370849089089e-07 31 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2436 5633522 8.09 µM 5.07497390036235 0.000115537496426559 yes 102 1.93774596413661e-07 4 5724242 SGTC_2662 daunorubicin 22.37 µM 5.06018053802483 0.000120428951119926 yes 103 2.09429844669215e-07 12 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_93 0109-0045 59.227 µM 5.05725045085731 0.000121420560678772 yes 104 2.12672238089865e-07 8 88733 SGTC_1037 k284-1091 78.7 µM 5.01990431416961 0.000134749088577825 yes 105 2.58486123165564e-07 2 3334711 SGTC_2092 5303694 80.6725 µM 4.95773281820273 0.000160021207093399 yes 106 3.56602756359145e-07 4 1963699 SGTC_3154 9100113 49.47 µM 4.94438222617917 0.000165997748046896 yes 107 3.81928516739752e-07 4 25237525 SGTC_1113 artemisinin 1.17947 µM 4.93632591350867 0.000169704633138191 yes 108 3.98040158857802e-07 22 2240 An anti-malaria and mitochondrial poison. SGTC_103 0844-0104 51.839 µM 4.90778044548684 0.00018347168350227 yes 109 4.60564434248829e-07 37 5375804 SGTC_1168 k815-0004 80.5 µM 4.89775824419362 0.000188548023366717 yes 110 4.84680966101621e-07 10 642433 SGTC_3 0833-0587 95.581 µM 4.87632902175077 0.000199845760075328 yes 111 5.40391408715064e-07 7 5382644 SGTC_2475 5812728 15.03 µM 4.86326276899504 0.000207041591674991 yes 112 5.77331976788679e-07 11 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3311 9131146 2.8755 µM 4.83191048312907 0.000225306685791205 yes 113 6.76145298656232e-07 12 4900406 YPR165W RHO1 SGTC_1686 st019653 115.5 µM 4.82510993496431 0.000229462102843619 yes 114 6.99630319941394e-07 2 97252 SGTC_2850 9015429 58.44 µM 4.79531240513543 0.000248526834482018 yes 115 8.12107528849907e-07 3 6457570 SGTC_2849 9019321 12.99 µM 4.73838414668667 0.000289120440882886 yes 116 1.07714567435659e-06 3 16489627 SGTC_635 k038-0028 24.7 µM 4.63191498427985 0.000382071027163623 yes 117 1.81149465906838e-06 10 4035102 SGTC_709 3807-1509 243 µM 4.61217594546257 0.000402095291718941 yes 118 1.99237736484028e-06 11 1886677 YPL242C IQG1 SGTC_666 0272-0154 136 µM 4.60432741658638 0.000410324473444414 yes 119 2.06900503913127e-06 11 6870312 SGTC_1067 clotrimazole 1.36 µM 4.5823878104491 0.00043416436974498 yes 120 2.29848174125217e-06 16 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_922 1866-0035 480 µM 4.55650655087039 0.000463936252677059 yes 121 2.60057088758951e-06 6 3156169 SGTC_863 0466-0191 129 µM 4.52980975404211 0.000496619479859339 yes 122 2.95184110439212e-06 18 765160 YPR165W RHO1 SGTC_2408 sulbentine 18.36 µM 4.51123955484653 0.000520597139591545 yes 123 3.22249416759509e-06 27 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_660 4031-1742 102 µM 4.48597155662298 0.000554945510772977 yes 124 3.62912123091579e-06 6 6738706 SGTC_16 erodoxin 22.806 µM 4.47450637528719 0.000571211862673652 yes 125 3.82940207874939e-06 25 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_921 1561-0023 372 µM 4.45798019916502 0.000595435098264329 yes 126 4.13677711972836e-06 5 24050882 SGTC_2974 9094440 9.66 µM 4.45719847639907 0.000596604082630611 yes 127 4.15188574865254e-06 9 25236134 SGTC_2765 myclobutanil 7.74 µM 4.41025364651027 0.000670819669536977 yes 128 5.16248040767491e-06 5 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2997 9067075 71.4286 µM 4.40838438007977 0.000673944037869476 yes 129 5.20722961360512e-06 17 27209819 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 4.38410563088798 0.000715762660377974 yes 130 5.82316278475077e-06 5 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2001 4023502 57.655 µM 4.38144299909739 0.00072049158054201 yes 131 5.89479443967549e-06 5 108941 YCR052W RSC6 SGTC_576 1073-0113 22.7 µM 4.36789987354262 0.000744993484507782 yes 132 6.27234882526908e-06 37 5439563 SGTC_3285 9112818 20.8695 µM 4.36484271487675 0.000750629593462194 yes 133 6.36071293285323e-06 10 17017947 YPR165W RHO1 SGTC_566 0958-0068 16.5 µM 4.3571732537527 0.000764942167326316 yes 134 6.58764874700227e-06 15 6815365 SGTC_2526 patulin 37.61 µM 4.33394266161945 0.000809842402112176 yes 135 7.32311684907484e-06 10 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2766 oltipraz 83.91 µM 4.33330135749094 0.000811115642663551 yes 136 7.34449097226153e-06 19 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_591 4299-0174 154 µM 4.33172385045911 0.000814255457556729 yes 137 7.39732137891671e-06 2 5509088 SGTC_757 1066-0008 322 µM 4.3161711501573 0.000845815280254726 yes 138 7.93794517787235e-06 2 6842497 SGTC_555 4296-0685 37 µM 4.29605469283737 0.000888304866155322 yes 139 8.69323519083235e-06 3 2908540 YHR072W ERG7 SGTC_590 k048-0076 22.4 µM 4.28929495199215 0.000903017401550105 yes 140 8.96206034708321e-06 9 6832814 SGTC_3076 9116187 49.47 µM 4.27609583514337 0.000932392696945315 yes 141 9.50996863091785e-06 6 27241210 SGTC_257 daunorubicin 18.5 µM 4.26137034749638 0.000966199334852066 yes 142 1.01588606764427e-05 14 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2006 4011487 200 µM 4.25851773370003 0.000972877068843927 yes 143 1.02893448468209e-05 15 45595294 SGTC_1274 0865-0114 173 µM 4.25403055068251 0.000983466989331754 yes 144 1.04978318515552e-05 5 870624 SGTC_2738 aclarubicin 5.55 µM 4.22066570971146 0.00106558917256744 no 145 1.21790962234826e-05 6 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2447 5741742 33.78 µM 4.2098523044162 0.00109352472873206 no 146 1.27768841582949e-05 7 1776504 SGTC_2025 5147754 141 µM 4.17943404483791 0.00117574673499728 no 147 1.46117728323362e-05 4 315777 YLR208W SEC13 SGTC_1693 xanthone 101.9 µM 4.12702745097239 0.00133079081164474 no 148 1.83741270709805e-05 7 7020 An insecticide. SGTC_3000 9075062 71.4286 µM 4.10339951026585 0.00140662585145736 no 149 2.03561664936227e-05 6 17057871 SGTC_1773 st048542 73.5835 µM 4.10295600758643 0.00140808629164561 no 150 2.03952416492135e-05 23 3237138 SGTC_951 1171-0579 82.7 µM 4.09493065739343 0.00143475386992563 no 151 2.11147380421069e-05 20 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_746 1095-0025 46.6 µM 4.04075880141742 0.00162716097315515 no 152 2.66392666440694e-05 10 6749286 SGTC_1237 0330-0133 46.1 µM 4.01128309656973 0.00174146180821272 no 153 3.01948219320541e-05 9 X1237 YHR072W ERG7 SGTC_580 1123-0028 41 µM 3.9868485911265 0.0018417014018025 no 154 3.34783620770044e-05 24 1677248 YPR107C YTH1 SGTC_2433 5607874 27.82 µM 3.9614691014376 0.00195134637921496 no 155 3.72450113991045e-05 3 2252428 SGTC_957 1187-1561 14.1 µM 3.92334007607426 0.00212724373371918 no 156 4.36648713004201e-05 7 1538454 SGTC_2793 7325131 81.82 µM 3.91929679834655 0.00214671548609801 no 157 4.44038494526247e-05 7 4176441 SGTC_710 3448-4187 58 µM 3.82161414059017 0.00266906109871642 no 158 6.62905120466731e-05 10 3946412 SGTC_1870 st057514 26.5 µM 3.81463643511818 0.00271044122648973 no 159 6.81917858190821e-05 10 5393161 SGTC_895 0964-0006 13.7 µM 3.79881727448151 0.00280640691493502 no 160 7.26941140224531e-05 14 6738897 SGTC_2648 atorvastatin 78.68 µM 3.74666378637006 0.0031448896841894 no 161 8.96010067459498e-05 8 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1090 efavirenz 20.7 µM 3.72867375027897 0.00326990768798823 no 162 9.62450837617849e-05 5 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1311 1190-0148 100 µM 3.71194091430284 0.00339018244562788 no 163 0.000102838003012273 9 1961333 SGTC_1084 voriconazole 435 nM 3.70575991898199 0.0034356070734295 no 164 0.000105378934288234 14 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1133 3473-0247 50 µM 3.70360636014182 0.00345156174027522 no 165 0.000106278001369745 53 711311 SGTC_1282 0886-0010 32.4 µM 3.69028967989018 0.00355170536707625 no 166 0.000111999412145135 15 2836211 YNL267W PIK1 SGTC_212 3807-4682 38.772 µM 3.68368897446515 0.00360230428670423 no 167 0.000114941357314941 26 3125501 YBL034C STU1 SGTC_44 0929-0055 61.211 µM 3.68216751353886 0.00361405868618578 no 168 0.000115629684318114 9 1379590 SGTC_200 k038-0079 37.545 µM 3.67206554089089 0.00369298069722647 no 169 0.000120298977582947 14 3436683 SGTC_525 k781-2675 26.7 µM 3.66910736233651 0.0037163824123278 no 170 0.00012169942612153 44 3651118 YDL195W SEC31 SGTC_1317 1273-0028 910 nM 3.65765412047906 0.00380824674222659 no 171 0.000127267104860594 14 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_403 arphamenine a 50 µM 3.65373837592526 0.00384011803135665 no 172 0.000129224809347026 7 5487158 An arginine aminopeptidase inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM 3.65314613364053 0.00384495920630499 no 173 0.00012952335193252 7 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2185 6113692 200 µM 3.64611647702465 0.00390284102997198 no 174 0.000133116668599852 10 874150 SGTC_2066 5222451 176 µM 3.62798665297051 0.00405574031035558 no 175 0.000142820011780341 27 2281147 SGTC_934 2950-0684 338 µM 3.62710607458573 0.00406330145341838 no 176 0.000143307784605353 6 1121253 SGTC_98 0074-0023 107.663 µM 3.62059083525491 0.00411963813987593 no 177 0.000146965516801777 1 3563821 SGTC_2071 5230951 39.92 µM 3.62040128750924 0.00412128755428169 no 178 0.000147073228893216 8 1799272 SGTC_2105 5350118 200 µM 3.61207970716476 0.00419428562097991 no 179 0.000151875582378811 8 2133313 SGTC_2188 6126565 140.678 µM 3.58855735440467 0.00440692162574279 no 180 0.000166256424213872 7 874518 SGTC_216 k038-0035 28.382 µM 3.56598678997692 0.00461995505621846 no 181 0.000181244815532096 20 4444231 YPR107C YTH1 SGTC_898 1000-0849 28.3 µM 3.56192743098163 0.00465923007298562 no 182 0.000184071076755561 4 6751807 SGTC_2930 9013230 14.89 µM 3.54876022324697 0.00478868348034945 no 183 0.000193524675095221 25 2995857 SGTC_1105 epirubicin 18.1 µM 3.52947342344058 0.00498409213758003 no 184 0.000208193761869084 13 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1723 st034307 2.5525 µM 3.52860850028166 0.00499301938413826 no 185 0.000208875327613695 19 867466 SGTC_2002 4023503 131 µM 3.50634381005228 0.00522777921400302 no 186 0.000227153990252004 15 4736863 YCR052W RSC6 SGTC_2380 9035439 200 µM 3.49735654274026 0.00532529003797945 no 187 0.000234946680556788 10 6462575 SGTC_2067 5224629 34.075 µM 3.48321493805524 0.0054820016634726 no 188 0.000247715213557938 17 2835000 SGTC_2337 9009472 200 µM 3.46700162898814 0.00566670248711766 no 189 0.000263149350205293 11 5742383 SGTC_630 4356-0227 183 µM 3.42665538152898 0.00615051224363391 no 190 0.00030553202137233 11 779312 SGTC_1884 5633444 25 µM 3.41225111463422 0.00633190493568577 no 191 0.000322143657134293 22 5724239 SGTC_2201 6605497 169.863 µM 3.38619642343761 0.00667207053549049 no 192 0.000354343191154689 6 670741 SGTC_1789 tunicamycin 25 nM 3.3844012802428 0.00669609166295043 no 193 0.000356668327743514 21 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_36 0335-0881 14.2 µM 3.34233371244905 0.00728131803209543 no 194 0.000415385579160765 43 23828853 SGTC_2124 5246320 200 µM 3.33564829434769 0.00737836273917923 no 195 0.000425503760489839 38 579342 SGTC_246 cycloheximide 667 µM 3.32532870050011 0.00753039891598836 no 196 0.000441571750812607 17 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_248 streptozotocin 5.23457 mM 3.32521092789066 0.00753214984081175 no 197 0.000441758331317917 21 5300 DNA alkylating agent. SGTC_268 camptothecin 39.6153 µM 3.31842619150661 0.00763362576902868 no 198 0.00045263121723941 57 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2258 7960471 200 µM 3.3177209631106 0.00764424226594938 no 199 0.00045377549911611 9 2974708 SGTC_2718 lomofungin 53.02 µM 3.31479479497483 0.00768843174455414 no 200 0.000458552108285841 14 5351222 A RNA synthesis inhibitor. SGTC_1468 k284-1086 134 µM 3.29990970393083 0.007916717477478 no 201 0.000483579706763794 20 15996457 SGTC_1503 4585-0012 61.3 µM 3.29886086200058 0.0079330256245663 no 202 0.000485390078508693 11 2922052 SGTC_1735 st034310 56.75 µM 3.2691855472543 0.00840684658509643 no 203 0.000539287739241812 17 871153 SGTC_150 3970-0969 77.2 µM 3.26447629163621 0.00848427939912936 no 204 0.000548333203162605 31 6615640 SGTC_2292 7671323 168.05 µM 3.25440079336281 0.00865205267077245 no 205 0.000568159203202361 21 937504 SGTC_2852 9023854 51.95 µM 3.25291237896374 0.00867708224989726 no 206 0.000571143572494068 13 19798528 SGTC_1309 pyrazolanthrone 13.4 µM 3.24563581478859 0.00880036310628015 no 207 0.000585943252367604 16 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1969 st069479 40.1 µM 3.23455077543321 0.00899111886450612 no 208 0.000609171276534316 8 3895485 SGTC_2753 fluvastatin 17.09 µM 3.21250623924008 0.00938125930807927 no 209 0.000657911452078544 18 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_674 0498-0004 451 µM 3.21000775920463 0.00942639788725248 no 210 0.00066365694651568 34 4231473 SGTC_185 k048-0037 25.491 µM 3.20256008504821 0.00956207957345046 no 211 0.000681059408490553 7 6827589 SGTC_2743 auranofin 4.32 µM 3.19978185333228 0.00961312887716737 no 212 0.000687658200376934 16 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_960 1222-0186 7.7 µM 3.19724674647094 0.00965991850871443 no 213 0.000693730929696058 19 3126296 SGTC_1097 itavastatin 7.23 µM 3.19137553143105 0.0097690464660455 no 214 0.000707985530849239 15 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3006 9075424 71.4286 µM 3.18209547534987 0.00994373098309408 no 215 0.000731068050434012 13 7465181 SGTC_2759 disulfiram 3.38 µM 3.16750700659421 0.0102238529771348 no 216 0.000768760025230587 32 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2370 9071495 200 µM 3.16668833789685 0.0102397746970122 no 217 0.000770927336531084 19 21791103 SGTC_3322 9139058 2.11 µM 3.16271389751998 0.0103173785350056 no 218 0.000781529308829665 22 4908926 YPR165W RHO1 SGTC_3226 9131256 49.47 µM 3.15840848378461 0.0104020230321509 no 219 0.000793165537677998 3 17178073 SGTC_825 1988-2224 89.6 µM 3.15563435152889 0.0104568826223893 no 220 0.000800747450378172 18 1180859 SGTC_48 0382-0018 55 µM 3.13490852001503 0.010874782401161 no 221 0.000859538552641046 2 762596 SGTC_1480 1070-0044 41.2 µM 3.13372590961464 0.0108990599639434 no 222 0.000863009991821289 9 3124987 SGTC_2035 5154463 94.595 µM 3.12307036121016 0.0111199408627648 no 223 0.000894874780637697 19 2769623 SGTC_2756 carbadox 75.1 µM 3.1168357974828 0.0112509752036145 no 224 0.000914016800046539 34 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1818 st052136 56.3 µM 3.09745596534395 0.0116668958624793 no 225 0.000975946963407486 31 674169 SGTC_2938 9059746 27.26 µM 3.09583860908771 0.0117022026611091 no 226 0.000981285749730583 21 6471769 SGTC_2771 fluoxetine 41.05 µM 3.08716480678265 0.0118931379121664 no 227 0.00101037763909953 10 3386 A selective serotonin reuptake inhibitor. SGTC_970 1315-0089 19.5 µM 3.08091919184995 0.0120322899909247 no 228 0.00103181322984008 16 6811083 YLR033W RSC58 SGTC_3350 9150499 3.57 µM 3.06266984583103 0.0124470033068804 no 229 0.00109685972112605 26 4910996 YPR165W RHO1 SGTC_1895 st058434 18.3 µM 3.06223608400636 0.0124570092406989 no 230 0.00109845053863983 13 5393175 SGTC_440 fluspirilene 35.1 µM 3.05582694532898 0.0126056678205101 no 231 0.00112220378088066 9 3396 An atypical antipsychotic. SGTC_1028 k015-0029 4.8 µM 3.04508485684342 0.0128582727840468 no 232 0.00116307334382537 10 4588309 SGTC_2965 9082772 38.63 µM 3.03722086775209 0.013045962836636 no 233 0.00119385215886968 5 16459634 SGTC_3111 9122088 49.47 µM 3.03171212847491 0.0131788464166271 no 234 0.00121585495298868 4 16876704 SGTC_893 0958-0369 48.9 µM 2.98669685911201 0.0143092221460728 no 235 0.00141004603187529 10 6819948 SGTC_846 0335-0850 148 µM 2.97804375213107 0.0145358241068471 no 236 0.00145047285487688 13 6819598 SGTC_142 0335-0849 62.6745 µM 2.97300451494379 0.0146692061894661 no 237 0.00147450056709328 35 3889043 YPR107C YTH1 SGTC_1386 3228-0095 33.8 µM 2.95031543845387 0.015282878628553 no 238 0.00158724821521372 7 870181 SGTC_1991 st073000 8.92 µM 2.942054270505 0.0155117305306976 no 239 0.00163021390829556 32 4301969 YIL048W NEO1 SGTC_2180 6301957 200 µM 2.93689804160446 0.0156560548837771 no 240 0.0016575653886259 19 845462 SGTC_1745 st081495 74 µM 2.93340457583642 0.0157544914356808 no 241 0.00167633348291483 48 13842402 YBL026W LSM2 SGTC_794 k038-0031 316 µM 2.92407016800334 0.0160201182435357 no 242 0.00172743429036061 31 6624242 SGTC_2359 9039622 200 µM 2.92131008126063 0.016099392962936 no 243 0.00174281359060439 10 6463596 SGTC_3100 9120536 49.47 µM 2.90993473256762 0.0164296711676311 no 244 0.00180752119939428 16 16421196 SGTC_1982 st072467 71.9 µM 2.89184345546584 0.0169668897712675 no 245 0.00191494362776651 22 3163533 SGTC_274 sirtinol 40.1 µM 2.88416848446691 0.0171992944122426 no 246 0.00196224361548219 22 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1195 1502-0147 41.1 µM 2.86611453795832 0.017756729905202 no 247 0.00207771934538609 16 817940 SGTC_1058 3448-5425 97.3 µM 2.86610176703495 0.0177571296134078 no 248 0.00207780316774215 25 7279705 SGTC_506 n9-isopropylolomoucine 153 µM 2.85754325119526 0.0180267287044603 no 249 0.00213467222844903 10 6610355 SGTC_2532 xanthone 78.9 µM 2.85674464288309 0.0180520624938958 no 250 0.00214005012054193 11 7020 An insecticide. SGTC_1259 0671-0132 43 µM 2.85386038220052 0.0181438111406494 no 251 0.00215957543128237 22 X1259 SGTC_3234 9132280 49.47 µM 2.83958824937878 0.0186036796996161 no 252 0.00225858992628483 16 17612295 SGTC_2928 9011484 9.79 µM 2.8379222210725 0.0186580027497042 no 253 0.00227041230756362 50 2994751 SGTC_1162 k048-0130 20.1 µM 2.83655307218047 0.0187027466740071 no 254 0.00228016992118773 26 6797406 SGTC_2991 9074669 71.4286 µM 2.83024656442187 0.0189100249089885 no 255 0.00232560721444263 46 17333109 SGTC_222 nsc-310342 10.666 µM 2.82454250963228 0.0190991819862469 no 256 0.00236740835319719 4 432556 SGTC_3236 9132701 49.47 µM 2.82003131196821 0.0192499187953914 no 257 0.00240094818106679 17 24282524 SGTC_4 0960-0234 25.671 µM 2.81208037569977 0.0195180525695349 no 258 0.00246111009141945 23 6821112 SGTC_81 0411-0046 9.971 µM 2.80784260329961 0.01966225673029 no 259 0.00249372983947181 56 12925265 SGTC_2147 5545932 89.7195 µM 2.80335291372222 0.0198160190480535 no 260 0.00252871474467658 28 797404 SGTC_3214 9129694 49.47 µM 2.79731845275966 0.020024293200889 no 261 0.00257643584664669 19 17158655 SGTC_512 prima-1 270 µM 2.76196133430217 0.0212822785039874 no 262 0.00287276411075547 26 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1774 st048371 48.465 µM 2.75412195981701 0.0215700741290638 no 263 0.00294249168453097 26 4242727 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.75159627739341 0.0216634935554193 no 264 0.00296527920694866 28 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1746 st038117 42 µM 2.74401826005626 0.0219458416640772 no 265 0.00303460809170063 18 2898218 SGTC_1731 st035964 63 µM 2.74016483003602 0.0220906036702689 no 266 0.00307041895976171 33 6739575 SGTC_1548 st061468 90.8 µM 2.73372640271386 0.0223342745897147 no 267 0.00313110274962459 5 390799 SGTC_2845 9003024 42.97 µM 2.69303953084821 0.0239271189788616 no 268 0.0035401936751865 30 2990173 SGTC_370 0180-0345 38.7 µM 2.69222992362433 0.0239597587091134 no 269 0.00354879976414885 26 3989527 SGTC_1803 st050068 52.4 µM 2.6920461118094 0.0239671743863439 no 270 0.00355075629007076 39 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1075 aripiprazole 15.2 µM 2.69196732673135 0.0239703534705944 no 271 0.00355159518903326 17 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1687 st020778 55.3625 µM 2.69163386140668 0.023983813170974 no 272 0.00355514787938697 29 4259299 SGTC_1239 0337-0584 35.4 µM 2.68189319265878 0.0243797882107413 no 273 0.00366034142873392 53 914301 YML130C ERO1 SGTC_1524 corynanthine 62.1 µM 2.66734481639835 0.0249814159171186 no 274 0.00382265936692865 29 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1872 amphotericin b 148 nM 2.65817182223316 0.0253671134917092 no 275 0.00392829132037668 32 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1457 k015-0032 57.3 µM 2.65707869406656 0.0254134072276015 no 276 0.00394105207613517 21 4302660 SGTC_247 mechlorethamine 29.705 µM 2.63846497162329 0.0262126179303258 no 277 0.00416411518923049 9 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1765 st044815 90.4 µM 2.63012983978725 0.0265772539772738 no 278 0.00426761314500903 30 645695 SGTC_439 amiodarone 34.4 µM 2.62813625063273 0.026665092491589 no 279 0.00429270602272661 25 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_667 1498-1044 59 µM 2.61947424675999 0.0270495650622945 no 280 0.00440327109533557 22 6739982 SGTC_1085 doxorubicin 7.67 µM 2.61126987265288 0.0274179806448319 no 281 0.00451033383982917 32 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_767 0929-0023 86 µM 2.61114868458772 0.0274234537722848 no 282 0.00451193255153092 35 1204563 SGTC_2525 harmine 47.85 µM 2.60846446138442 0.0275449131224693 no 283 0.00454747276014229 18 5280953 A monoamine oxidase inhibitor SGTC_1002 4049-0206 172 µM 2.57389062796745 0.0291498424404061 no 284 0.00502810284328569 35 4662749 SGTC_1320 1313-0481 95.3 µM 2.56980245184857 0.0293446527137054 no 285 0.00508782614615223 15 6813365 YLR208W SEC13 SGTC_2308 7584454 197.62 µM 2.56424257524292 0.0296113264882809 no 286 0.00517006250840996 43 893577 SGTC_531 3788-1495 174 µM 2.55901812661519 0.0298637417247982 no 287 0.00524841339702743 22 2896655 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.550101268017 0.0302986744830761 no 288 0.00538458163131005 20 390807 SGTC_2256 7954252 200 µM 2.54805400372163 0.0303992702886363 no 289 0.00541628502466065 35 2972920 SGTC_2778 tioconazole 65.09 nM 2.54409240857451 0.0305947158720469 no 290 0.0054781047630245 60 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_507 nimesulide 162 µM 2.54024702515638 0.0307854223672124 no 291 0.00553870992032175 21 4495 A COX2 inhibitor. SGTC_925 2064-1272 59.6 µM 2.53655236737182 0.0309695798123609 no 292 0.00559749989061782 29 6815817 SGTC_2973 9094665 17.96 µM 2.53615412965237 0.0309894839880439 no 293 0.00560386968196893 52 25237061 YIL048W NEO1 SGTC_113 0099-0221 2.5 µM 2.52084551802036 0.0317626802225804 no 294 0.00585366185169942 25 89219 SGTC_2088 5278280 127.392 µM 2.52018511261749 0.0317963909273156 no 295 0.00586465658898698 20 791502 SGTC_2043 5101342 149 µM 2.51527160793386 0.0320481321899082 no 296 0.00594703567056938 26 678451 SGTC_693 4161-2696 114 µM 2.51386416121609 0.0321205445724876 no 297 0.00597082099063583 24 805759 SGTC_1898 st060199 18.6 µM 2.494435081506 0.0331340352365761 no 298 0.00630789006569699 29 688866 SGTC_883 0850-0245 24.6 µM 2.48311856433734 0.0337363895793322 no 299 0.00651188655374347 37 6823229 YPR165W RHO1 SGTC_233 rapamycin 362 pM 2.48292601081476 0.0337467162436868 no 300 0.00651540752116995 14 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2323 6148992 148.28 µM 2.47069420058386 0.0344080590699635 no 301 0.00674255387927798 29 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1788 fluconazole 20 µM 2.46417448522913 0.0347648918576399 no 302 0.0068664620034682 33 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_558 k064-0027 21.3 µM 2.46169117729923 0.0349016032908781 no 303 0.00691418390747253 41 5088526 SGTC_2776 terbinafine 19.92 µM 2.45518305262265 0.0352619844223534 no 304 0.00704064320147475 33 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1276 0871-0068 94.2 µM 2.45113215008921 0.0354878365247492 no 305 0.00712038299656981 35 3414906 SGTC_2226 7298446 200 µM 2.44978193974841 0.0355633785449348 no 306 0.00714713762944032 17 3283010 SGTC_71 0417-1750 47.813 µM 2.44655133353386 0.0357446607251058 no 307 0.00721151284960809 33 6811472 SGTC_188 3229-0966 278.469 µM 2.43686826136385 0.0362925574332995 no 308 0.00740753780745074 58 5722370 SGTC_2688 kanamycin b 96.69 µM 2.43354941562118 0.0364819220836407 no 309 0.00747579719830734 62 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1793 st048256 72.231 µM 2.43122799794007 0.0366148560445621 no 310 0.00752387105492054 22 672022 SGTC_2585 alliin 100 µM 2.42289548083033 0.037095277831577 no 311 0.00769867798972237 29 87310 A garlic compound which reacts with lipids. SGTC_2519 cryptotanshinone 88.04 µM 2.4215313984797 0.0371744142752907 no 312 0.00772763290809215 53 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.41815053002318 0.0373711481933718 no 313 0.00779981099745984 24 688761 SGTC_1082 camptothecin 424.86 nM 2.40638319628733 0.038062534547656 no 314 0.00805567759487237 52 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2617 dihydrotanshinone i 20.83 µM 2.40511416069744 0.0381377156678701 no 315 0.00808370719078875 61 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_733 4069-0007 56.1 µM 2.4044233292722 0.0381786932852124 no 316 0.00809900180936964 44 5717425 YNL287W SEC21 SGTC_373 0844-0104 25.9 µM 2.38735337931241 0.0392026775386669 no 317 0.00848508520538968 49 5375804 SGTC_1101 ebselen 5.29 µM 2.38610778989747 0.0392782641813484 no 318 0.00851387970695896 36 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_586 0957-0265 8.15 µM 2.37378468214101 0.0400324813003643 no 319 0.00880340723873372 73 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.34685859851456 0.0417214210088669 no 320 0.00946621909290203 19 16486 A toxic proline analog. SGTC_648 0375-0473 33.3 µM 2.34537464288086 0.0418161552001033 no 321 0.00950398462388993 32 1713139 SGTC_1244 0416-0015 52.5 µM 2.3383612239197 0.042266244199672 no 322 0.00968425873572776 24 96201 SGTC_1300 1094-0077 113 µM 2.33002809151288 0.0428061131084582 no 323 0.00990233322350101 30 5532636 SGTC_2121 5257820 149.641 µM 2.32990587614876 0.0428140722095403 no 324 0.00990556319452025 24 791256 SGTC_605 1315-0399 119 µM 2.32804874468691 0.0429351624864837 no 325 0.00995475774219744 40 24020461 SGTC_954 1189-0853 2.85 µM 2.32529102571735 0.0431154840675471 no 326 0.0100282019209294 35 2828194 SGTC_1920 st075728 45.7 µM 2.32457556055795 0.0431623666737087 no 327 0.0100473334374684 31 3400306 SGTC_1019 4262-0212 3.4 µM 2.30268462985757 0.0446168365054909 no 328 0.0106482968024554 43 4677213 SGTC_1076 itraconazole 331 nM 2.28611231050386 0.0457439775990239 no 329 0.0111238444903667 38 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1752 st044819 83.042 µM 2.27528376209569 0.0464927485569106 no 330 0.0114444564439942 36 441209 YML126C ERG13 SGTC_1153 4055-0057 267 µM 2.2750226997018 0.0465109211845786 no 331 0.0114522840741525 46 882706 SGTC_2108 5365811 200 µM 2.26152117854132 0.047458563632691 no 332 0.0118635013767801 36 780283 SGTC_235 0330-0087 5 mM 2.24620639121191 0.0485521335404114 no 333 0.0123453955294244 36 46494818 YHR062C RPP1 SGTC_137 0438-0332 85.389 µM 2.24484478447698 0.0486503280265357 no 334 0.0123890493104679 92 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2019 4016004 108 µM 2.24157359848867 0.0488868838397328 no 335 0.0124944719502587 49 45595336 SGTC_2471 5466956 24.79 µM 2.24059394275216 0.0489579062093361 no 336 0.0125261947169368 61 724419 SGTC_120 rhodamine 6G 52.259 µM 2.23492982247074 0.049370157100941 no 337 0.0127109781622569 80 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2452 5863136 48.41 µM 2.23251709841939 0.0495466016413278 no 338 0.0127904032182802 42 2184096 SGTC_1713 st033146 12.748 µM 2.22603726345029 0.0500229690056954 no 339 0.0130058427679745 44 674619 SGTC_2411 st077133 39.94 µM 2.22460894289597 0.0501284621594041 no 340 0.0130537508846984 64 1403142 YNL221C POP1 SGTC_2533 agelasine 13.65 µM 2.22237732359276 0.0502936404538533 no 341 0.0131289082541233 56 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2761 levamisole 97.89 µM 2.22066052346289 0.0504210082424213 no 342 0.0131869815673672 30 26879 An alkaline phosphatase inhibitor. SGTC_2903 5923464 63.88 µM 2.21772567398824 0.0506393370646628 no 343 0.0132867713016651 28 2876576 SGTC_1036 k216-0215 33.5 µM 2.21430713868829 0.050894596798774 no 344 0.0134038289434056 34 622330 SGTC_2541 muurolladie-3-one 83.07 µM 2.20913102284926 0.0512830424472432 no 345 0.0135827644390006 72 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2233 sulbentine 40.3845 µM 2.20397300044408 0.0516724728368669 no 346 0.0137631214707003 76 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1487 3970-0795 2.82 µM 2.19772477014249 0.0521473585865854 no 347 0.0139843626382149 42 3765103 SGTC_2874 9043904 71.43 µM 2.18967302620024 0.0527644216298577 no 348 0.0142739793376556 39 4463428 SGTC_907 3448-6986 75.5 µM 2.18636991386971 0.0530192326575587 no 349 0.0143942764531837 45 590582 SGTC_1984 st072354 53.1 µM 2.18200455499535 0.0533574841826053 no 350 0.0145545982786903 35 5762938 SGTC_1873 rapamycin 2 nM 2.17607342401801 0.0538197980071346 no 351 0.0147748853789994 46 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2587 piperic acid 92.2 µM 2.1760354031844 0.053822771816225 no 352 0.0147763067036996 32 5370536 SGTC_3336 9143619 71.43 µM 2.16286182137954 0.0548610038209749 no 353 0.0152759044923899 18 45595730 SGTC_2151 5563267 85.4165 µM 2.15508398159444 0.0554813809762531 no 354 0.0155776314867952 56 5310824 SGTC_2804 7954240 19.48 µM 2.14184911940242 0.0565497382238805 no 355 0.0161028126625044 47 828705 SGTC_1801 st050089 28.441 µM 2.13733220416387 0.0569180449175496 no 356 0.0162854906513029 53 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2600 tangeritin 87.95 µM 2.13640344276059 0.0569940092068277 no 357 0.0163232718436387 45 68077 A bioactive flavone. SGTC_1453 4237-0541 195 µM 2.13423621604508 0.0571715792180353 no 358 0.0164117247602183 59 739892 SGTC_3297 9117502 71.43 µM 2.12015344008399 0.0583360698270854 no 359 0.0169965537288684 17 7453720 SGTC_1831 st055328 12 µM 2.11647183748886 0.0586435492091609 no 360 0.0171523489784681 53 1103068 SGTC_1290 0986-0249 10.2 µM 2.11490834846527 0.0587745126419032 no 361 0.0172188797581244 38 53329 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.11456815778679 0.0588030386124724 no 362 0.0172333849815879 48 94937 An inhibitor of serotonin biosynthesis. SGTC_524 r073-0010 27.8 µM 2.09142335103443 0.0607694389548011 no 363 0.0182450653801555 63 2772106 SGTC_1415 3966-0071 78.1 µM 2.08460631735112 0.0613583183114736 no 364 0.0185525252920695 50 2893185 SGTC_1552 6-methylflavone 10.6 µM 2.08054202453006 0.0617115217175271 no 365 0.0187379226150702 48 689013 SGTC_1218 1348-1416 30.7 µM 2.08029177901195 0.0617333208301557 no 366 0.0187493891953426 53 6787668 SGTC_2311 7694451 200 µM 2.07257105868739 0.0624088381193035 no 367 0.019106108395519 62 2163142 SGTC_808 0711-0032 135 µM 2.0696707037758 0.0626640862292679 no 368 0.0192415960004003 55 4252555 SGTC_1111 tnp00062 510.699 nM 2.06448631412046 0.0631223689322582 no 369 0.0194858150950226 35 676306 SGTC_426 0988-0037 14.6 µM 2.06017344146263 0.0635055977168307 no 370 0.0196909814621026 61 5383008 SGTC_10 0279-0212 42.575 µM 2.05886571516136 0.0636221553617557 no 371 0.0197535521241826 35 39851 YBR002C RER2 SGTC_272 doxorubicin 8.13 µM 2.04182431437864 0.0651563165731816 no 372 0.0205844807463178 51 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_176 1486-1328 72.834 µM 2.03436894645175 0.0658364507315417 no 373 0.0209572051984507 65 22310231 SGTC_1053 3366-3204 134 µM 2.03046220438206 0.0661950433026596 no 374 0.0211547896306004 58 3632071 YPR165W RHO1 SGTC_695 3505-6186 243 µM 2.02801141897111 0.0664207673451495 no 375 0.0212795412924773 69 1819379 SGTC_756 0508-1999 28.3 µM 2.02717081373083 0.0664983264977982 no 376 0.0213224734375338 62 6753853 SGTC_2004 4023728 41.89 µM 2.025304635853 0.0666707615588084 no 377 0.0214180464000675 80 360084 YDR527W RBA50 SGTC_1916 st067606 49.2 µM 2.02496244423881 0.0667024176154295 no 378 0.0214356103659459 65 19590279 SGTC_2157 5649910 96.377 µM 2.02186033001242 0.0669899243070598 no 379 0.0215953915138331 50 2858091 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.02112961581034 0.0670577868276122 no 380 0.0216331746544452 62 23847180 SGTC_2620 irigenin 100 µM 2.01720822914833 0.0674228804915955 no 381 0.0218368938351027 74 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2605 digitonin 300 nM 2.01405384340445 0.0677176773143494 no 382 0.0220019403862873 67 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_628 1636-0253 16 µM 1.99838146280617 0.069197142686057 no 383 0.0228376598882223 61 4456143 SGTC_2837 9008476 45.46 µM 1.99387563301805 0.069627067325313 no 384 0.0230828237345155 48 2992805 SGTC_219 mitoxanthrone 164.414 µM 1.97941073802269 0.071021142625041 no 385 0.0238848902497639 51 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1030 k029-0042 36.7 µM 1.97901392206471 0.0710596862629188 no 386 0.0239072194076633 51 6080581 SGTC_2316 5844804 197.44 µM 1.97704835184361 0.071250843476642 no 387 0.0240180824977461 68 776813 SGTC_896 0964-0007 44.5 µM 1.97106163816883 0.0718355008474474 no 388 0.0243584129746871 55 6756758 SGTC_544 k015-0020 52.4 µM 1.96419173009324 0.0725109358829751 no 389 0.0247539307516074 57 3008304 SGTC_196 k015-0023 18.111 µM 1.96153403863632 0.0727735357436904 no 390 0.0249083791588102 32 5211998 SGTC_1417 3966-0327 90.4 µM 1.95913206903759 0.0730114942442277 no 391 0.0250486610147084 46 651118 SGTC_1911 st060208 74.3 µM 1.95609928012495 0.0733127968914623 no 392 0.0252267299755872 56 688783 SGTC_892 0929-0076 29 µM 1.95605263024993 0.0733174388972093 no 393 0.0252294772660615 52 5751038 SGTC_744 1594-0068 283 µM 1.94013729610519 0.0749142922934999 no 394 0.0261815032304256 62 668392 SGTC_160 3453-0671 289.699 µM 1.93807475901618 0.0751231626058943 no 395 0.0263070512063207 49 5322268 SGTC_1167 k781-0610 148 µM 1.92743944749694 0.0762072406120377 no 396 0.0269624437556535 71 4525169 SGTC_3081 9117243 49.47 µM 1.92568179280394 0.0763875425565084 no 397 0.0270720593384137 100 45595589 SGTC_2799 7812892 81.82 µM 1.92487243888214 0.07647067593569 no 398 0.02712265935258 82 20205235 SGTC_721 1187-1332 279 µM 1.92367814150549 0.0765934747571029 no 399 0.0271974697780579 53 25730 SGTC_2016 5121758 140 µM 1.923511269477 0.0766106446373521 no 400 0.0272079362855525 80 2795203 SGTC_2685 mycophenolic acid 18.85 µM 1.9083231861105 0.078185674114407 no 401 0.0281747290209746 35 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_91 0417-1751 58.384 µM 1.90715438000187 0.0783078915743394 no 402 0.0282502995267399 67 6795624 SGTC_1702 st027038 51 µM 1.90422278101377 0.0786150747019343 no 403 0.0284405880015342 52 5521182 SGTC_969 1313-0238 134 µM 1.8939928039172 0.0796941633307861 no 404 0.0291129825199691 99 5212874 SGTC_380 3970-0968 6 µM 1.88817027323116 0.080313324713668 no 405 0.0295015476051036 53 2891601 SGTC_3299 9121982 43.1275 µM 1.87591975614265 0.0816278910435642 no 406 0.0303331496960806 54 17594604 YPL160W CDC60 SGTC_1005 4092-0690 4.4 µM 1.87537428228066 0.0816867992448829 no 407 0.0303706253133783 79 1529343 SGTC_1769 st044406 64.4 µM 1.86855026038766 0.0824264670580868 no 408 0.0308427056852692 87 670903 SGTC_2641 levomentholum 100 µM 1.86837268140699 0.082445782256867 no 409 0.0308550710921645 42 16666 SGTC_755 1995-0008 37.3 µM 1.86385049871505 0.0829388074372564 no 410 0.0311713509353614 34 689533 SGTC_1936 st074407 74.3 µM 1.86377099661696 0.0829474948464649 no 411 0.0311769351825303 74 809813 SGTC_698 k064-0052 127 µM 1.85262422495283 0.0841723203555968 no 412 0.0319681188863704 55 5088751 SGTC_3351 9150312 21.596 µM 1.85161963312545 0.0842833699575284 no 413 0.0320402308776533 83 4904905 SGTC_2301 7769476 200 µM 1.84979441380489 0.0844854146831357 no 414 0.0321715931566131 70 977820 SGTC_256 clotrimazole 625 nM 1.84961467592778 0.0845053306078393 no 415 0.0321845530254426 79 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1329 1447-1697 50.6 µM 1.84821660444373 0.0846603647186313 no 416 0.0322855071494668 54 2840515 SGTC_3277 9138724 49.47 µM 1.84281978160742 0.08526082736757 no 417 0.0326776638012746 55 15943418 SGTC_1798 st045719 60.953 µM 1.84181338258696 0.0853731537127021 no 418 0.0327512259261881 60 3980186 SGTC_914 3820-6779 408 µM 1.83519392435795 0.0861147293718331 no 419 0.0332384805253253 55 2893481 SGTC_3231 9132313 49.47 µM 1.83498524475792 0.0861381857838227 no 420 0.0332539378756734 59 4905967 SGTC_574 1315-0397 40 µM 1.82533478039252 0.0872281645912838 no 421 0.0339752623443671 80 6794277 SGTC_3293 9120939 62.045 µM 1.82529513062316 0.087232664008265 no 422 0.0339782523021113 64 934087 SGTC_1126 isoteolin 1.0172 µM 1.82049946466834 0.0877781503843466 no 423 0.0343414888528121 63 133323 SGTC_306 1672-3436 11.6 µM 1.81909403650908 0.0879384928981038 no 424 0.034448542365214 59 6797378 SGTC_281 1672-3440 14.9 µM 1.81868954400162 0.0879846811001598 no 425 0.0344794039137032 56 6833000 SGTC_1148 3909-7663 27.7 µM 1.8157885641658 0.0883164684972201 no 426 0.0347014060972481 47 4084526 SGTC_3099 9120367 49.47 µM 1.81299516486693 0.0886368321620517 no 427 0.0349162835359116 58 24824940 SGTC_2231 micatex 6.853 µM 1.80919572262522 0.0890739630560103 no 428 0.035210300963031 64 20737 An antifungal of unknown mechanism. SGTC_1672 st016598 6.51 µM 1.80594593741192 0.0894491265808 no 429 0.0354633923145296 93 4665860 YNL267W PIK1 SGTC_1965 Pectolinarigenin 58.4 µM 1.80129709241469 0.0899878424793929 no 430 0.0358280329437708 48 5320438 An anti-inflammatory. SGTC_3201 9113999 49.47 µM 1.80055858302275 0.0900736436311322 no 431 0.0358862410599887 64 16649224 SGTC_1953 st076800 12.1 µM 1.79957796515961 0.090187667234394 no 432 0.0359636514884722 87 297591 SGTC_1622 st003707 19.4 µM 1.79254616364456 0.0910084489284303 no 433 0.0365227606846054 60 10140899 SGTC_2386 9075165 157.42 µM 1.78602309729658 0.0917747910059457 no 434 0.0370477592178042 68 16452277 SGTC_2192 5915882 198.485 µM 1.78148488644007 0.0923107613818117 no 435 0.0374166358714529 76 2876149 SGTC_839 0122-0028 230 µM 1.78074115305151 0.092398818034231 no 436 0.0374773734348918 119 759448 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.7783168576155 0.0926862816253736 no 437 0.0376759146033276 68 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2987 9018338 71.43 µM 1.77475252359559 0.0931101269776696 no 438 0.0379693793032996 85 5055682 SGTC_2026 5148700 152 µM 1.7639483483766 0.0944036328347095 no 439 0.0388703378779954 66 79838 SGTC_1579 chlormadinone acetate 49.4 µM 1.76058975309898 0.0948084205792777 no 440 0.0391539321072446 79 45114258 A steroidal progestin. SGTC_3048 9093155 49.47 µM 1.75819934142177 0.0950972981062759 no 441 0.0393567986340162 59 25236002 SGTC_1389 3405-0187 19 µM 1.74490410549196 0.0967158438201378 no 442 0.0405007813077619 63 799890 SGTC_625 k213-0058 121 µM 1.74242519885662 0.0970198475610396 no 443 0.0407170348765385 112 3655420 SGTC_3080 9117754 49.47 µM 1.73499232440747 0.0979355910618139 no 444 0.041371082376432 72 9550191 SGTC_1583 clindamycin 39.6 µM 1.73364542607982 0.0981022070844052 no 445 0.0414905075880241 74 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1277 0873-0036 22 µM 1.73193016014633 0.09831469198883 no 446 0.0416429990115272 59 5965735 SGTC_529 4076-0302 30.3 µM 1.72985673087896 0.0985719954512467 no 447 0.0418279378062324 58 5816522 SGTC_3149 9097855 49.47 µM 1.72719610947922 0.0989028885731499 no 448 0.0420662246666835 61 25236625 YMR079W SEC14 SGTC_2659 sanguinarine 24.21 µM 1.72332688730072 0.0993855407512087 no 449 0.0424147140825388 69 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2978 9011784 42.97 µM 1.72099325428626 0.0996774725552254 no 450 0.0426260239926168 59 2994934 SGTC_621 3584-0052 32.1 µM 1.71964971902716 0.0998458294782212 no 451 0.0427480663623551 79 2273927 SGTC_345 1362-0200 395 µM 1.71891278792683 0.0999382616632054 no 452 0.0428151266411166 76 1419823 SGTC_3217 9129673 49.47 µM 1.7181808489698 0.100030129534241 no 453 0.0428818167764045 73 17248312 SGTC_776 4476-4378 112 µM 1.71491450652083 0.10044084969687 no 454 0.0431804512973866 68 2892008 SGTC_1176 0848-0131 83.3 µM 1.7140575553813 0.100548808909994 no 455 0.0432590779909513 67 6769040 SGTC_3216 9129716 49.47 µM 1.70643555161639 0.101512760340442 no 456 0.043963508061177 63 8056934 SGTC_1481 3346-2004 36 µM 1.70294014981874 0.101957066354876 no 457 0.0442896346823642 81 2770522 SGTC_1155 4088-0394 48.2 µM 1.69804211230904 0.102582042137226 no 458 0.0447499069543346 80 2326248 SGTC_1466 k213-0079 57.5 µM 1.69026441498101 0.103580168854142 no 459 0.0454886898823137 105 3657981 SGTC_1057 3448-5381 134 µM 1.68465402206872 0.104304523995308 no 460 0.0460276710423042 92 5497911 SGTC_1358 1509-0022 2.48 µM 1.68398548223006 0.104391083050259 no 461 0.0460922372372731 83 3258434 SGTC_1207 2099-0101 141 µM 1.68349151709121 0.104455072513157 no 462 0.0461399900878652 77 5837381 SGTC_2084 5306078 60.6385 µM 1.6790355189571 0.10503359839625 no 463 0.0465725608099967 78 679340 SGTC_792 4534-1957 155 µM 1.67404111302736 0.105684778680647 no 464 0.0470612597998826 67 1717904 SGTC_3187 9109394 49.47 µM 1.67120978281144 0.106055226820986 no 465 0.0473401243119117 94 17098090 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.66985188415795 0.106233225293454 no 466 0.0474743360446061 65 97141 SGTC_1092 toremifene 6.32 µM 1.66886679312558 0.106362489720874 no 467 0.0475718909443506 77 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_916 4466-0038 42 nM 1.65922178829836 0.107634118622409 no 468 0.0485355543301893 109 5722064 YGL116W CDC20 SGTC_1665 st014639 11.4 µM 1.65893587305 0.107671981078514 no 469 0.0485643575051295 86 981133 YIL048W NEO1 SGTC_3208 9114115 49.47 µM 1.65630176617 0.108021255375585 no 470 0.048830361507467 116 650895 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.65302009910173 0.10845753442661 no 471 0.0491633865434943 82 66535 A nucleotide analog. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.64986727227297 0.108877877596921 no 472 0.0494850429110008 39 4000243 SGTC_1202 1988-0068 29.6 µM 1.63122234893444 0.111387621727536 no 473 0.0514217056024251 70 2850480 SGTC_2934 9036370 36.88 µM 1.63097800061138 0.111420785438381 no 474 0.0514474807908865 73 6462800 SGTC_1461 k072-0203 53.8 µM 1.61654068818768 0.113392821994369 no 475 0.0529887318639845 68 5418714 SGTC_1874 staurosporine 7.6 µM 1.61571993929203 0.113505673707522 no 476 0.053077438981387 84 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1029 k015-0030 64.7 µM 1.61350681714024 0.113810373672597 no 477 0.0533172216942276 89 2208316 SGTC_612 0302-0167 22.4 µM 1.6113527880795 0.114107497138996 no 478 0.0535514256147496 92 235821 SGTC_21 0849-0113 22.993 µM 1.60750623514763 0.114639458261505 no 479 0.0539716813647861 79 1560156 SGTC_3266 9136860 49.47 µM 1.5992060590414 0.115793342675833 no 480 0.0548874122422741 99 4871271 YPR165W RHO1 SGTC_771 0250-0039 27.3 µM 1.59682122792082 0.116126400346226 no 481 0.0551527813256475 93 3005115 SGTC_867 0518-0118 155 µM 1.59639752999528 0.116185643663523 no 482 0.0552000336329921 96 6848158 SGTC_1413 3910-0535 34.4 µM 1.59601594362793 0.116239017111022 no 483 0.0552426168716377 92 2876951 SGTC_2721 ifenprodil 61.44 µM 1.59073655168897 0.116979245046496 no 484 0.0558344386429583 84 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_879 0831-1030 162 µM 1.5848326127808 0.117810990871626 no 485 0.0565021852393253 121 1549252 SGTC_1062 mesoridazine 14.2 µM 1.57807644134174 0.118767923249415 no 486 0.0572740248454846 89 4078 A neuroleptic. SGTC_3096 9117468 49.47 µM 1.57689124937484 0.118936356272186 no 487 0.0574102751884286 62 41316311 SGTC_2843 9000894 45.46 µM 1.57531729245862 0.119160299109939 no 488 0.0575916122177072 42 2242070 SGTC_868 0527-0199 213 µM 1.57389750313485 0.11936256216252 no 489 0.0577555736347974 85 2849450 SGTC_1048 3161-0300 24.5 µM 1.57299983564924 0.119490568729692 no 490 0.0578594281341821 62 2165101 SGTC_2268 7933382 153.85 µM 1.57259305662692 0.119548606924072 no 491 0.0579065382260012 91 935025 YOR257W CDC31 SGTC_3219 9131112 49.47 µM 1.5723670906679 0.119580855761424 no 492 0.0579327209300788 101 17612988 YMR079W SEC14 SGTC_1744 st037937 38.9 µM 1.56939303006632 0.120005872151322 no 493 0.0582781935628627 84 1016152 SGTC_3209 9113616 49.47 µM 1.56334518975297 0.120873436954947 no 494 0.0589857122924059 104 16649353 SGTC_1606 st000094 49.2 µM 1.55553191142932 0.122000775937891 no 495 0.0599097202898592 97 1242210 SGTC_3045 9092950 49.47 µM 1.55453598889109 0.122145001518083 no 496 0.0600283095247249 64 44120432 SGTC_1518 st038567 90.8 µM 1.55236245197421 0.122460180197326 no 497 0.0602877612200304 84 77966 SGTC_329 k048-0121 21.3 µM 1.55132081437763 0.122611427349092 no 498 0.0604124105792184 85 6832902 SGTC_2249 haloperidol 116.36 µM 1.5485743317482 0.123010848400073 no 499 0.0607420401450148 134 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2702 st077768 96.8 µM 1.54674452730688 0.123277462689859 no 500 0.0609624306915399 77 6484119 SGTC_1371 2421-0008 32.7 µM 1.54655715043335 0.123304787544344 no 501 0.0609850345137278 119 2827552 SGTC_3110 9122132 49.47 µM 1.54363067752666 0.123732100950856 no 502 0.0613389143999516 73 918317 SGTC_3331 9141060 1.957 µM 1.53517884226742 0.124972025784158 no 503 0.0623699519698021 72 4906567 YPR165W RHO1 SGTC_2132 5317594 122.667 µM 1.53511951194462 0.124980760397309 no 504 0.0623772371377255 82 794577 SGTC_1913 st060213 96.1 µM 1.53249336424249 0.125367809257702 no 505 0.0627003669247831 90 688959 SGTC_2427 5545055 42.75 µM 1.53121778925321 0.125556108601731 no 506 0.0628577878282636 91 5372858 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.52887522248084 0.125902430242105 no 507 0.0631476898868208 78 17037758 SGTC_1356 1502-0781 85.8 µM 1.52676187746857 0.126215435179262 no 508 0.0634101172256671 99 567702 SGTC_3279 9140807 49.47 µM 1.52645313367667 0.126261208209739 no 509 0.0634485268481839 73 45595718 SGTC_2733 amorolfine 100 µM 1.52316184736052 0.126749879281441 no 510 0.0638591093420536 92 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1175 0741-0056 27.6 µM 1.52264804791376 0.126826283918101 no 511 0.0639233910267634 95 765927 SGTC_834 0312-0008 75.7 µM 1.52201799704919 0.126920019503029 no 512 0.0640022856537467 93 6385573 YIL048W NEO1 SGTC_3247 9135149 49.47 µM 1.5212937531155 0.127027828191922 no 513 0.0640930686003361 131 8934436 YOR116C RPO31 SGTC_597 k018-0003 82.8 µM 1.51988145927854 0.127238241114476 no 514 0.0642703855377176 83 6786234 SGTC_2293 7624732 200 µM 1.51892901975518 0.127380278711845 no 515 0.0643901817403683 98 894453 SGTC_2941 9056145 11.23 µM 1.51481349999997 0.127995295037701 no 516 0.0649098203497227 83 2119517 SGTC_2746 daunorubicin 9.88 µM 1.51296100462352 0.128272801019899 no 517 0.0651447822105176 55 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1992 st073643 23.3 µM 1.51237724088776 0.128360336018661 no 518 0.0652189606760809 96 3161292 SGTC_2693 st077581 40.7 µM 1.50005349067797 0.130217958408628 no 519 0.0668002735627891 92 25238761 SGTC_875 0709-0210 25.7 µM 1.49574709810771 0.130871447407557 no 520 0.0673597859256715 104 6251364 SGTC_2491 paeonol 100 µM 1.48991461374686 0.131760126899171 no 521 0.0681233442774666 77 11092 Increases levels of cortical cytochrome oxidase. SGTC_1465 k213-0056 144 µM 1.48766911792765 0.132103374412232 no 522 0.0684190878421043 118 24048857 YMR208W ERG12 SGTC_1478 0453-0656 35.7 µM 1.48689209436138 0.132222294054674 no 523 0.0685216562916661 102 5258496 SGTC_1941 st076221 61.8 µM 1.47754984546384 0.133657858044039 no 524 0.069764153612125 110 2828568 SGTC_1893 st059353 36.1 µM 1.47531082299354 0.134003500430077 no 525 0.0700644989983191 112 3112488 SGTC_2815 7968870 71.43 µM 1.47245887179332 0.134444650549178 no 526 0.0704485027271651 99 2977326 YHR190W ERG9 SGTC_1944 st076371 56.9 µM 1.47125527367217 0.134631126321063 no 527 0.0706110470466126 98 24208455 SGTC_2087 5276107 200 µM 1.47051386962988 0.134746081786993 no 528 0.0707113160416407 97 144405 SGTC_2300 7976697 71.57 µM 1.47046976130831 0.134752922950073 no 529 0.0707172847875484 74 2236109 SGTC_2608 thymoquinone 42.66 µM 1.47045766967772 0.134754798393293 no 530 0.0707189210967585 88 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_122 0236-0016 402.397 µM 1.46890361600547 0.134995985226818 no 531 0.0709294668650406 126 6808838 SGTC_3130 9127414 49.47 µM 1.45929641512786 0.136493580164806 no 532 0.0722417708317832 94 1494646 SGTC_1495 4469-0029 237 µM 1.45777218073202 0.136732222130259 no 533 0.0724516743429032 94 793680 SGTC_2876 9059903 25.97 µM 1.45374607267041 0.137363941495321 no 534 0.0730083597891857 101 6916095 SGTC_19 0279-0214 38.434 µM 1.45252153462107 0.137556473161271 no 535 0.0731783229240638 106 3566274 YBR002C RER2 SGTC_2949 9072542 2.23 µM 1.45130655223213 0.137747684387121 no 536 0.0733472587984086 107 16457352 SGTC_664 1222-0054 14.9 µM 1.45092677744579 0.137807489687234 no 537 0.073400125310436 118 6813991 SGTC_1804 st050076 49.1 µM 1.44023926919367 0.139497779061043 no 538 0.0748998583531183 110 3895976 SGTC_684 1140-0066 328 µM 1.43736544758677 0.139954685645201 no 539 0.0753070906249612 104 6813534 SGTC_2794 7785382 27.27 µM 1.43411931308903 0.140472007869923 no 540 0.0757691087045275 117 2205081 SGTC_1967 st070177 51.4 µM 1.43342926117562 0.140582145524137 no 541 0.0758676005705286 103 5729214 SGTC_902 1120-0002 2.07 µM 1.43266701364731 0.14070387427786 no 542 0.0759765102982963 119 3280475 SGTC_2829 7992743 58.44 µM 1.43029374747287 0.141083336062961 no 543 0.0763163642906404 90 16462845 SGTC_3031 9088762 49.47 µM 1.42751338601394 0.14152877036105 no 544 0.0767159847800476 106 205253 SGTC_2315 7733312 200 µM 1.42710355573284 0.141594508671354 no 545 0.0767750238757808 103 726316 SGTC_3342 9147791 14.508 µM 1.41627861144691 0.143338361082687 no 546 0.0783469737568984 94 1838168 SGTC_760 0568-0725 82.9 µM 1.4133015514875 0.143820484779181 no 547 0.0787835390079576 106 3916171 SGTC_2349 9023730 187.07 µM 1.41216210966673 0.144005302280922 no 548 0.0789511171393668 94 4126287 SGTC_2543 pimpinellin 60.67 µM 1.40838911650351 0.144618424824255 no 549 0.0795079400799018 105 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1108 betulinic acid 729.144 nM 1.40258218580849 0.145565499648173 no 550 0.0803707335187518 99 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2078 5212016 200 µM 1.39995783647097 0.145994880231316 no 551 0.0807629724584423 102 1899708 SGTC_2812 7970281 58.44 µM 1.3925202022522 0.147216401693703 no 552 0.0818824641915933 130 2233435 SGTC_1638 st008370 60.6 µM 1.38788940403833 0.147980392791173 no 553 0.0825853624352195 116 24207134 SGTC_2878 9043973 25.97 µM 1.38731051655928 0.148076084176184 no 554 0.0826735488370436 90 6465167 SGTC_367 0335-0881 7.1 µM 1.38616539294549 0.148265497607769 no 555 0.0828482030877634 131 23828853 SGTC_614 0462-0418 107 µM 1.38616388494291 0.148265747151367 no 556 0.0828484332711957 97 5188303 SGTC_2594 a-mangostin 100 µM 1.38302227547419 0.14878622936248 no 557 0.0833290179109828 119 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1914 st062367 72.6 µM 1.38300064331807 0.148789817470752 no 558 0.0833323343182052 125 978205 SGTC_445 e6 berbamine 66 µM 1.38298413759831 0.148792555300061 no 559 0.0833348648626218 135 6610268 A calcium/calmodulin antagonist. SGTC_438 sphingosine 6.67 µM 1.38293022851781 0.148801497517321 no 560 0.0833431302377262 92 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1651 st011928 86.1 µM 1.38113752588231 0.149099068241534 no 561 0.0836183396706755 112 720198 SGTC_254 nsc-64875 3.808 µM 1.38053736801398 0.149198777195199 no 562 0.0837106262000987 90 56993 SGTC_2549 cedrol 20.94 µM 1.37923947281476 0.149414558989963 no 563 0.0839104657227381 129 6708665 A sedative which affects the nervous system. SGTC_577 r071-0003 38.6 µM 1.37887157926635 0.149475761071276 no 564 0.083967176146 121 4568517 YMR134W ERG29 SGTC_2030 5175110 200 µM 1.37741876082797 0.149717612711525 no 565 0.084191407912854 104 2831986 SGTC_1364 1653-0028 37.6 µM 1.37651591601795 0.149868041335925 no 566 0.0843309815950907 98 5718652 SGTC_520 3584-0023 682 µM 1.37325060702573 0.150412936226687 no 567 0.0848372259896518 121 1340790 SGTC_514 4466-0038 2.65 nM 1.37048945708356 0.150874728843364 no 568 0.0852670821200402 143 5722064 SGTC_3198 9112019 49.47 µM 1.37011657146614 0.150937164906592 no 569 0.0853252578358369 129 45595555 SGTC_322 k048-0136 19.3 µM 1.36833588811849 0.151235560101853 no 570 0.0856034810780519 126 6823282 SGTC_2107 5363541 170.161 µM 1.36832300084618 0.151237721095399 no 571 0.085605497125557 119 244052 SGTC_1562 morin hydrate 59.1 µM 1.3625409281511 0.152209356178648 no 572 0.0865136184085259 115 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1288 0973-0013 65.5 µM 1.36010539026131 0.152619868392512 no 573 0.0868982877901017 111 4315430 SGTC_82 0054-0107 293.755 µM 1.35926224217808 0.152762152794729 no 574 0.0870317520941465 103 3104697 SGTC_1424 4048-1941 275 µM 1.35725667045636 0.153100953971262 no 575 0.0873498348794802 115 X1424 SGTC_2023 5144124 124 µM 1.35542338285167 0.153411086572201 no 576 0.0876413519572119 117 2830192 SGTC_1475 4092-1048 11.7 µM 1.35452187504317 0.153563744882448 no 577 0.087784969639794 118 2881759 SGTC_140 0062-0056 502.533 µM 1.35291049523616 0.153836861057998 no 578 0.0880421130423404 104 3758964 SGTC_2468 5987765 72.9 µM 1.35130456419406 0.154109373386787 no 579 0.0882989452866156 109 26772094 SGTC_1003 4049-0218 100 µM 1.34984221733914 0.154357798367862 no 580 0.0885332998407758 135 295161 SGTC_343 4130-2827 29.8 µM 1.34802108822703 0.154667543646276 no 581 0.0888258000134738 108 1118244 SGTC_2906 7926292 26.41 µM 1.34682134509791 0.154871825256411 no 582 0.0890188892219006 102 2966319 SGTC_194 1486-1323 56.904 µM 1.34457397455069 0.1552549669559 no 583 0.0893814262834188 139 5178754 SGTC_888 0916-0002 6.97 µM 1.3431843567371 0.155492187925784 no 584 0.0896061428625298 94 2802138 YIL048W NEO1 SGTC_77 0828-0286 12.516 µM 1.34207882731735 0.155681083015059 no 585 0.0897852190464572 106 745345 SGTC_3309 9129340 25.759 µM 1.34056564991464 0.155939875667788 no 586 0.0900307580548655 102 17158987 SGTC_3064 1327-0027 10 µM 1.34027880337602 0.15598896583371 no 587 0.0900773600316637 82 16000455 YPR107C YTH1 SGTC_1527 coumarin 137 µM 1.33906777529592 0.156196330274722 no 588 0.0902743049692631 130 323 A hepatotoxic, DNA x-linker. SGTC_2214 7179297 48.276 µM 1.3387396821091 0.156252540951679 no 589 0.0903277165477027 94 769744 SGTC_2083 5306046 65.942 µM 1.33838930003348 0.156312584992973 no 590 0.0903847825324905 115 539837 SGTC_2474 5321570 43.32 µM 1.33766541969888 0.156436682562645 no 591 0.090502764166835 113 2841384 SGTC_2155 5570423 76 µM 1.3346234222381 0.15695889282012 no 592 0.0909998140804354 117 797402 SGTC_2989 9073649 71.4286 µM 1.33141868256435 0.157510279578783 no 593 0.0915256427188714 142 21367202 SGTC_3196 9111891 49.47 µM 1.32743816484702 0.15819691194499 no 594 0.0921818909878022 122 18891510 SGTC_1720 st037298 9.481 µM 1.32611907273439 0.158424885728387 no 595 0.0924001297615388 127 597396 SGTC_26 0302-0163 425.158 µM 1.32549072396074 0.158533556650441 no 596 0.0925042220140552 150 3100915 SGTC_2072 5231554 129 µM 1.32535304188026 0.158557374856509 no 597 0.0925270420095337 126 789545 SGTC_1730 st033808 45.1 µM 1.32405868422205 0.15878140599752 no 598 0.0927417778324375 118 1045166 SGTC_2583 asiatic acid 100 µM 1.32026390402014 0.15943941280296 no 599 0.0933734613100811 158 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_677 0929-0063 136 µM 1.31736624560479 0.159943060906996 no 600 0.0938579448083678 106 1539583 SGTC_114 0364-0001 490.298 µM 1.31589031891569 0.16019999436548 no 601 0.0941054292831398 135 4003655 SGTC_116 0155-0182 31.788 µM 1.31381556425967 0.160561629434115 no 602 0.0944541392918263 114 771486 SGTC_1616 st002734 56.1 µM 1.31041577441253 0.161155373496772 no 603 0.0950276100509229 126 4026101 SGTC_2366 9070441 60.58 µM 1.30968529370265 0.161283132400275 no 604 0.0951511603194597 109 6837235 SGTC_2129 girgensonine 121.053 µM 1.30676033174205 0.161795361259293 no 605 0.0956470606753709 151 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2592 piperlongumine 83.33 µM 1.30652114927932 0.161837294507218 no 606 0.0956876958133246 127 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3356 9151811 4.48 µM 1.30212880331626 0.162608615457806 no 607 0.0964361791639007 133 1859254 YPR165W RHO1 SGTC_1174 0739-0097 51.1 µM 1.30183405744437 0.162660460000305 no 608 0.0964865593104922 137 728447 SGTC_647 0140-0236 81 µM 1.30056398193283 0.162883983850009 no 609 0.0967038712226159 121 990837 SGTC_1147 3809-1045 12.3 µM 1.2989393217692 0.163170202970044 no 610 0.09698237686169 132 325925 SGTC_972 1319-0219 195 µM 1.29459607336325 0.163936964130421 no 611 0.0977298038302448 139 23903702 SGTC_2439 5492030 7.2 µM 1.29027380969046 0.164702337837267 no 612 0.0984778034666792 129 5722370 SGTC_3055 9094636 49.47 µM 1.2881580597827 0.165077831199348 no 613 0.0988454740274953 149 25236176 SGTC_2892 9047358 58.44 µM 1.28458628716087 0.165712989138056 no 614 0.0994684465512944 116 6466771 SGTC_563 tetrahydrosecaminediol 614 µM 1.28420865202728 0.165780235136994 no 615 0.0995344793464644 116 334274 A psychoactive constituent of the cannabis plant. SGTC_208 k072-0098 12.366 µM 1.28206800468373 0.166161756480062 no 616 0.0999093957827743 141 5948901 SGTC_837 0091-0265 12.5 µM 1.28090573832996 0.166369141218994 no 617 0.100113388508148 140 759367 SGTC_1437 4092-1038 11.6 µM 1.27627002621879 0.167197959414801 no 618 0.100930040995939 142 3977136 SGTC_1710 st031758 61.5 µM 1.27384691663466 0.167632244214984 no 619 0.101358837095498 128 5394341 SGTC_359 0081-0058 15.9 µM 1.27257780537565 0.167859991896097 no 620 0.101583949260427 141 3494159 SGTC_789 1309-1135 70.6 µM 1.26860068960341 0.168574992646097 no 621 0.102291759128021 113 3092424 SGTC_2123 5259487 200 µM 1.26745593740666 0.168781157061937 no 622 0.102496154674244 124 2173474 SGTC_3334 9142812 21.919 µM 1.2650081918823 0.169222527711922 no 623 0.102934195660712 127 45283678 SGTC_288 1315-0019 35.1 µM 1.26422954848703 0.169363085731954 no 624 0.103073824004737 162 6811474 SGTC_2785 7756463 72.73 µM 1.26273711134958 0.16963270472814 no 625 0.103341836119834 172 2201551 SGTC_2054 5233173 129 µM 1.26249763518754 0.169675993358897 no 626 0.103384888349942 73 6889 SGTC_1094 duloxetine 25.4 µM 1.26181993121247 0.169798536127612 no 627 0.103506794277145 116 60834 A selective serotonin reuptake inhibitor. SGTC_1131 3454-3128 32.3 µM 1.25852108002925 0.170395846275246 no 628 0.104101684234224 131 710982 SGTC_1497 4476-2978 41.3 µM 1.2552541469616 0.170988701779834 no 629 0.104693257424282 126 1528379 SGTC_1569 carminic acid 40.6 µM 1.25469293743339 0.171090678011332 no 630 0.104795125286492 123 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2466 5983409 37.09 µM 1.2508859711076 0.171783460641352 no 631 0.105488041448361 127 2879657 SGTC_2703 st077852 53.4 µM 1.25075330106655 0.171807635880784 no 632 0.105512248687769 151 6281836 SGTC_2616 abietic acid 100 µM 1.24801833549675 0.172306487490507 no 633 0.106012171297652 141 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1346 1488-2224 62.4 µM 1.23994765200198 0.173783942683588 no 634 0.107497378485215 142 3722427 SGTC_2149 5554786 194.827 µM 1.23990125661025 0.173792459257998 no 635 0.107505959526592 126 745063 YPR165W RHO1 SGTC_2227 7312221 64.1025 µM 1.23985640831632 0.173800692091591 no 636 0.107514254894333 146 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1477 0139-0234 16 µM 1.2302931585249 0.175561889005682 no 637 0.109293672662483 141 620880 SGTC_1463 k081-0032 34.1 µM 1.22408042602442 0.176712083464034 no 638 0.110460944641375 128 977755 SGTC_131 0141-0277 33.849 µM 1.22304965547821 0.17690337498005 no 639 0.110655471002953 162 1547771 SGTC_279 1273-0055 2.93 µM 1.22270830583487 0.176966751851342 no 640 0.110719944372773 159 2847562 SGTC_410 α-linolenic acid 100 µM 1.22243000212011 0.177018433881203 no 641 0.110772529683487 144 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_897 1000-0139 31.4 µM 1.2193135274201 0.177597825955827 no 642 0.111362608119486 136 6151020 SGTC_571 k831-0106 44.2 µM 1.21852188732885 0.177745192260975 no 643 0.111512856252744 145 4783639 SGTC_2497 7-hydroxyflavone 100 µM 1.21839293273769 0.177769204870444 no 644 0.111537344727113 147 5281894 SGTC_853 0419-0306 21 µM 1.21789189356136 0.17786252270007 no 645 0.111632528578279 159 762713 SGTC_401 neomycin 50 µM 1.21643482226667 0.178134075676943 no 646 0.111909662795346 135 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1853 st056710 91.2 µM 1.21465062267053 0.178466950985165 no 647 0.112249686271655 148 269167 SGTC_2487 5918373 44.05 µM 1.21391289999732 0.178604701171465 no 648 0.11239049315811 166 2876279 SGTC_360 0957-0399 1.01 µM 1.20988183196879 0.179358578477142 no 649 0.113162119801593 136 6752301 YPR165W RHO1 SGTC_1624 st003710 6.25 µM 1.20783943630869 0.179741303237619 no 650 0.113554514521464 129 24207033 SGTC_2700 st077718 96.8 µM 1.2059956021315 0.18008725987986 no 651 0.113909593080074 141 904970 SGTC_492 tmb-8 126 µM 1.20512766155504 0.180250255254723 no 652 0.114077011352933 124 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_407 eburnamonine 100 µM 1.20510586907942 0.180254348975745 no 653 0.114081217188631 131 3195 SGTC_638 3970-0837 4.09 µM 1.20156946479382 0.180919436126037 no 654 0.114765188983572 117 4118451 YLR208W SEC13 SGTC_3062 9077494 49.47 µM 1.20028062842499 0.181162207872528 no 655 0.115015185270189 135 16459633 SGTC_528 3492-0019 172 µM 1.20006527365583 0.181202793075541 no 656 0.115056995484399 162 2869262 SGTC_17 0960-0276 49.807 µM 1.19881389051731 0.181438738179767 no 657 0.115300160081718 161 6821114 SGTC_729 4092-0585 94.1 µM 1.19849277235466 0.181499315187175 no 658 0.115362617544375 132 2169061 SGTC_3063 1327-0034 4 µM 1.19502552376794 0.182154196836477 no 659 0.116038529009014 151 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1973 st070275 50.2 µM 1.1945896653148 0.182236624619109 no 660 0.116123694508658 110 17118334 SGTC_1435 4092-0789 56.7 µM 1.1918449875699 0.18275622238856 no 661 0.116661016085955 157 2248285 SGTC_435 c-PAF 6.7 µM 1.1913907577724 0.182842302209524 no 662 0.116750109741421 149 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2236 dapsone 200 µM 1.1911436369524 0.182889144013632 no 663 0.116798600831286 121 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_719 2810-4230 27.3 µM 1.19086954803276 0.182941106385954 no 664 0.116852400413111 126 721079 SGTC_1322 1348-1070 12 µM 1.19041679878676 0.18302695974673 no 665 0.116941306829794 143 6758089 SGTC_523 1934-0222 13.7 µM 1.19015615160834 0.1830763968198 no 666 0.116992511882223 156 1361595 SGTC_324 1315-0088 19.6 µM 1.18626022420745 0.18381633178923 no 667 0.117759774707043 149 6787421 SGTC_500 h-89 112 µM 1.18532130664292 0.183994934116232 no 668 0.117945216175192 159 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1474 0330-0125 5.35 µM 1.18497462933685 0.184060906904849 no 669 0.118013739076113 137 X1474 SGTC_3049 9092223 49.47 µM 1.18315688854987 0.184407064480375 no 670 0.118373487636674 122 8623917 SGTC_712 r015-0009 80.6 µM 1.18242222152044 0.184547084067716 no 671 0.118519105131514 131 6813872 YLR060W FRS1 SGTC_1315 1237-0019 3.69 µM 1.18057900895663 0.184898671384234 no 672 0.118885003260195 136 825140 SGTC_939 1165-0479 45.3 µM 1.18055391385156 0.184903461071367 no 673 0.118889990415618 132 1377347 SGTC_745 0469-0705 296 µM 1.17587339527602 0.185798139397149 no 674 0.119822735836428 185 3486736 SGTC_708 3448-5400 146 µM 1.17252608042151 0.186439620519431 no 675 0.12049295374681 179 3462195 SGTC_99 0109-0120 622.8 µM 1.17098881382394 0.186734682195989 no 676 0.120801636767625 141 759414 SGTC_2241 6772625 37.8075 µM 1.17059592944092 0.18681013845233 no 677 0.120880617146918 148 2285411 SGTC_2269 7935389 174.42 µM 1.15975952985861 0.188898779261842 no 678 0.123073362719616 147 97605 SGTC_2207 7258803 200 µM 1.15835310615226 0.189170908643166 no 679 0.123359983810824 151 3666799 SGTC_452 diindolylmethane 8 µM 1.15828812541015 0.189183487619817 no 680 0.123373237806842 136 3071 Inhibits expression of several cancer promoting factors. SGTC_1286 0929-0070 131 µM 1.15800749138447 0.18923781868946 no 681 0.123430489643061 156 1420408 SGTC_2630 antimycin a 100 µM 1.15733425166295 0.189368197834659 no 682 0.123567912403148 165 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.15541319681564 0.189740531875251 no 683 0.123960630144086 166 688801 SGTC_231 b-estradiol 524 µM 1.15521353142035 0.189779256335315 no 684 0.124001497431514 138 450 A steroid. SGTC_1783 st039459 87.517 µM 1.15490322481181 0.189839448947709 no 685 0.124065029348429 168 729761 SGTC_1897 st060201 15 µM 1.15327710448336 0.190155072196144 no 686 0.12439833226618 143 611878 SGTC_1139 k015-0024 46.9 µM 1.15187920920241 0.190426655476546 no 687 0.124685356400342 146 2766652 SGTC_3073 9114972 49.47 µM 1.15169678234555 0.190462114953018 no 688 0.124722847478241 121 41905075 SGTC_2706 st078239 82.5 µM 1.14987948698093 0.190815575628976 no 689 0.125096755358412 155 15434492 SGTC_3344 9148862 3.898 µM 1.14972018235936 0.190846579266542 no 690 0.125129569509747 151 4905352 SGTC_2809 7964133 12.99 µM 1.14891060693395 0.191004185436204 no 691 0.125296421724905 155 1253665 SGTC_598 3937-0236 20.2 µM 1.14772991067137 0.191234183563952 no 692 0.125540039712399 171 1379313 SGTC_2822 7994718 71.43 µM 1.14660310506514 0.191453842118884 no 693 0.12577284629622 177 1018011 SGTC_1408 3909-7976 48.8 µM 1.1454297244861 0.191682744200717 no 694 0.126015595522206 152 24152374 SGTC_1026 k007-1105 30.6 µM 1.14542968869945 0.1916827511845 no 695 0.126015602930732 173 7066794 SGTC_526 4469-0568 170 µM 1.14140820419758 0.192468529708907 no 696 0.126850046086368 141 2901964 SGTC_1777 st045864 34.765 µM 1.14112996624521 0.192522968796166 no 697 0.126907921380622 176 4691462 SGTC_1324 1418-0026 34.4 µM 1.14108848418764 0.192531085840041 no 698 0.126916551491223 135 1372513 SGTC_1341 1486-1360 280 µM 1.14016312817463 0.192712210200606 no 699 0.127109172852846 163 3976547 SGTC_162 k030-0015 37.8 µM 1.13822381943937 0.193092137986847 no 700 0.127513517456857 166 1809920 YMR134W ERG29 SGTC_2870 9038528 12.99 µM 1.13632153554198 0.193465256231233 no 701 0.127911010500661 146 6463316 SGTC_655 k060-0012 42 µM 1.1300969242008 0.194689236533369 no 702 0.129217692829558 173 5994525 SGTC_2960 9079389 5.97 µM 1.12953626293419 0.194799713315352 no 703 0.129335840539782 129 16457355 SGTC_1102 cgs 12066b 26.1 µM 1.12840429059783 0.195022881574943 no 704 0.129574608298622 134 6438352 A 5-HT1B full agonist. SGTC_819 1013-0258 27.7 µM 1.12830135097224 0.195043183821481 no 705 0.129596336566497 162 5753198 SGTC_205 1486-1330 71.903 µM 1.12577396811562 0.195542049327167 no 706 0.130130602756541 150 4118834 SGTC_1190 1486-1332 13 µM 1.12438070055903 0.19581738936174 no 707 0.130425777936873 159 4150046 SGTC_1171 0368-0077 21.4 µM 1.12405681459249 0.195881429977425 no 708 0.130494462128074 159 3239779 SGTC_480 am 92016 50 µM 1.12332322518537 0.196026526521626 no 709 0.130650121689426 189 2129 K+ channel blocker. SGTC_1861 st057647 17.4 µM 1.11798846679487 0.197083647350974 no 710 0.131785959574974 157 688668 SGTC_740 k014-0057 261 µM 1.11655772019277 0.197367745738605 no 711 0.132091738872444 173 4012779 SGTC_326 k292-0812 17.5 µM 1.11288904986956 0.198097351828809 no 712 0.132878041747894 147 3579357 SGTC_2869 9037858 32.47 µM 1.11245616052675 0.198183549900854 no 713 0.132971034675359 158 27187042 SGTC_1839 st053978 48 µM 1.11239271681622 0.198196184882634 no 714 0.132984667363727 141 3788398 SGTC_1556 plumbagin 1.48 µM 1.11105386559439 0.198462934019607 no 715 0.133272582097907 172 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_855 0428-0020 25 µM 1.10926849908361 0.198818982477216 no 716 0.13365718507489 152 6812414 SGTC_646 4092-0839 27.3 µM 1.10898769410614 0.198875017307864 no 717 0.133717745358863 169 877796 SGTC_1217 1183-1422 255 µM 1.10890651115537 0.19889121919646 no 718 0.133735257333079 157 2849664 SGTC_1833 st055984 71 µM 1.10647339061197 0.199377172422766 no 719 0.134260837585973 143 676288 SGTC_669 0108-0021 26.2 µM 1.10366974763519 0.199938013540848 no 720 0.134868211658947 158 17201 SGTC_470 aa-861 153 µM 1.10228460032092 0.200215448368625 no 721 0.135168981082958 168 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1925 st057770 10.1 µM 1.10051575101578 0.200570072040375 no 722 0.135553735335408 151 5989122 SGTC_1170 0310-0127 64.8 µM 1.09824530229574 0.201025810055813 no 723 0.136048694619774 182 774975 SGTC_736 0958-0254 92.6 µM 1.09795899732245 0.201083322969262 no 724 0.136111197015315 171 6812352 SGTC_2797 7859098 81.82 µM 1.09448335425817 0.201782296577685 no 725 0.136871521982689 164 972681 SGTC_777 1315-0167 517 µM 1.09428369147126 0.201822494157947 no 726 0.136915287826769 156 4221767 SGTC_2507 purpurin 79.67 µM 1.09398299481503 0.201883041667052 no 727 0.136981218220906 163 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1779 st039427 55 µM 1.08942287349095 0.202802588348138 no 728 0.137983724570666 163 1124498 SGTC_234 nsc-17383 10.7 µM 1.08784082458544 0.20312219163208 no 729 0.138332691757171 157 408974 SGTC_1683 st010134 710 nM 1.08491524850394 0.203714003946461 no 730 0.138979596854817 146 3818134 SGTC_3276 9139060 49.47 µM 1.08453463421545 0.20379107359036 no 731 0.139063909669376 191 4870619 SGTC_217 ketoconazole 989 nM 1.08301285023735 0.204099389478289 no 732 0.139401359657806 168 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2290 7904846 200 µM 1.08022943015117 0.204664033228866 no 733 0.14002001299166 154 2962154 SGTC_842 0271-0008 11.1 µM 1.07820270580083 0.20507575798425 no 734 0.140471652350427 167 1221709 SGTC_912 3474-0017 2.18 µM 1.07738800860766 0.205241400609787 no 735 0.140653479508939 159 3360550 SGTC_1810 st050138 53 µM 1.07384132947385 0.205963430118565 no 736 0.141446901385055 198 3444541 SGTC_2187 6125751 200 µM 1.07206023264252 0.206326591646754 no 737 0.141846489557713 173 874498 SGTC_835 0312-0010 67.2 µM 1.06853811469165 0.207045859586441 no 738 0.142638923508707 181 1626196 SGTC_2183 6420625 130.508 µM 1.06761488517439 0.207234641653287 no 739 0.142847133185814 187 2897619 SGTC_3235 9132602 49.47 µM 1.06657256543673 0.207447897593989 no 740 0.143082447232054 187 4912240 SGTC_1391 3442-0225 151 µM 1.06641837678784 0.207479455205677 no 741 0.143117279075764 152 5227075 SGTC_1635 st007035 42.4 µM 1.06601940493792 0.207561125479832 no 742 0.143207435027596 169 3716403 SGTC_804 1595-0054 20.9 µM 1.06595739349989 0.20757382104132 no 743 0.143221451239961 175 761523 Stimulates phospholipase C. SGTC_2492 derrusnin 100 µM 1.06489062861508 0.207792290960758 no 744 0.143462713169273 187 1715307 Part of coumarin class of compounds. SGTC_2897 9048598 12.99 µM 1.06331850171834 0.208114504783859 no 745 0.143818768773557 145 6467404 SGTC_465 cgp-37157 41 µM 1.06225940238129 0.208331737660447 no 746 0.144058969621175 142 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2669 eugenol 100 µM 1.06072103829688 0.208647511121239 no 747 0.144408348023889 135 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1226 3909-7979 35.4 µM 1.05346717165679 0.21014027859615 no 748 0.14606346619252 188 6615510 SGTC_2971 9092186 9.93 µM 1.05227439815183 0.210386337724173 no 749 0.146336837119293 151 25236400 SGTC_3267 9137951 49.47 µM 1.04924534224386 0.211011966126559 no 750 0.147032607450935 187 16643986 SGTC_3160 9100216 49.47 µM 1.04892387471839 0.21107842674664 no 751 0.147106578126499 172 17191039 SGTC_1499 4480-0877 67.3 µM 1.04848719611647 0.211168725906369 no 752 0.147207099188467 159 2861909 SGTC_1012 4112-3522 18 µM 1.04790104140911 0.211289970258787 no 753 0.1473421012128 166 3112398 SGTC_2480 5767542 37.17 µM 1.04782048789116 0.211306635700414 no 754 0.147360660626891 171 2867358 SGTC_464 bw-b 70c 158 µM 1.04776854739581 0.211317381900046 no 755 0.147372628472663 184 5353454 SGTC_1087 pterostilbene 9.05 µM 1.04695903414192 0.211484907062662 no 756 0.147559236286111 187 5281727 Similar to reservatol, lowers cholesterol. SGTC_3166 9102297 49.47 µM 1.04594719869983 0.211694411213718 no 757 0.147792705597193 172 25237072 SGTC_2273 7815444 169.05 µM 1.04517097704121 0.211855212990039 no 758 0.14797197732513 191 2824616 SGTC_2763 lisinopril 49.32 µM 1.04304730557078 0.212295516979062 no 759 0.148463191989086 166 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3257 9139206 32.98 µM 1.04167358838368 0.212580616469067 no 760 0.14878151908024 175 4910041 SGTC_3143 9086658 49.47 µM 1.03964011112393 0.213003051954306 no 761 0.149253567084376 193 25236626 SGTC_1353 1498-1206 8.11 µM 1.03865129085444 0.213208646792494 no 762 0.149483471160518 172 6756808 SGTC_2324 6149169 200 µM 1.03712032242901 0.213527192903042 no 763 0.149839892572561 176 2888231 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.03657442065986 0.21364084483964 no 764 0.149967119749257 188 688788 SGTC_1623 st003709 20.3 µM 1.03048461623165 0.214911075851883 no 765 0.151391285076747 181 16192618 SGTC_2917 7979103 53.79 µM 1.02644002549989 0.215757128325887 no 766 0.152342109839244 158 2980565 SGTC_304 1310-0298 97 µM 1.02533396913002 0.215988830294152 no 767 0.152602816417052 207 1550234 SGTC_2365 9042475 200 µM 1.02448742149239 0.216166266480967 no 768 0.152802554510901 180 6464479 SGTC_1590 st077108 57.8 µM 1.02148889385332 0.21679543577856 no 769 0.153511434155971 168 5489485 SGTC_688 0527-0193 473 µM 1.01956606728053 0.217199451529675 no 770 0.15396715245788 204 4007154 SGTC_462 ag-879 158 µM 1.01851075656562 0.217421373441283 no 771 0.154217645800837 197 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1470 k295-0292 231 µM 1.01652621887675 0.217839057412758 no 772 0.154689434304557 199 5045612 SGTC_1540 guanosine 70.6 µM 1.01540591970192 0.218075050057355 no 773 0.154956186198577 161 6802 Guanosine is a purine nucleoside SGTC_328 k915-0120 63.5 µM 1.01259124901351 0.218668614335241 no 774 0.155627720744616 152 6624543 SGTC_796 1234-0020 70.7 µM 1.01090729547583 0.219024174517605 no 775 0.156030400976861 168 46495034 SGTC_2228 7354201 200 µM 1.00776916366497 0.219687665133529 no 776 0.156782646362045 217 753451 SGTC_2760 etidronate 98.04 µM 1.00669342466593 0.219915372390755 no 777 0.157041061453294 169 3305 A chelator and antioxidant. SGTC_634 1611-4317 11.2 µM 1.0047258242954 0.220332214809324 no 778 0.157514444809039 199 2843522 SGTC_412 gemfibrozil 100 µM 1.00252658589002 0.220798666118357 no 779 0.158044666438814 161 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1767 st044992 70.3 µM 1.00252165151914 0.22079971331775 no 780 0.158045857398386 179 9600693 SGTC_2622 2-methoxyxanthone 59.94 µM 1.00143139917053 0.221031162408329 no 781 0.158309145124345 176 71034 A hepatoprotective. SGTC_1805 st050013 60.3 µM 1.00134753621407 0.221048971379758 no 782 0.158329409309092 181 4037144 SGTC_1661 st013063 9.66 µM 0.999290265030356 0.221486106498635 no 783 0.158827049959471 194 721395 SGTC_1156 4092-0367 4.88 µM 0.99874677642846 0.221601671045086 no 784 0.158958687362895 212 1357585 SGTC_2152 5568786 200 µM 0.989565370807354 0.223559158097469 no 785 0.161193301543817 196 5399883 SGTC_2725 haloperidol 53.21 µM 0.989150842937164 0.223647767371014 no 786 0.161294672532772 206 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1636 st007707 68.9 µM 0.988663254734259 0.223752019541519 no 787 0.161413963318988 196 403051 SGTC_956 1185-0240 191 µM 0.987053874761135 0.224096320179371 no 788 0.161808114075227 181 1416193 SGTC_931 2812-0076 566 µM 0.985898751269633 0.224343625433055 no 789 0.162091399864316 178 3450959 SGTC_2272 7805186 180 µM 0.984583989758765 0.224625296685845 no 790 0.162414228535656 210 2956062 YPR165W RHO1 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.984572075540415 0.224627850075349 no 791 0.162417155884031 203 5282309 SGTC_800 3448-7362 155 µM 0.98279788040074 0.22500826951897 no 792 0.16285346263413 224 15991913 SGTC_511 blebbistatin 171 µM 0.980524283422932 0.225496303032798 no 793 0.163413694445632 187 3476986 A myosin inhibitor. SGTC_725 1497-0963 19 µM 0.976226237195559 0.226420524771812 no 794 0.164476182004651 182 3549977 SGTC_2037 5169046 200 µM 0.975334831604982 0.22661247386993 no 795 0.164697099028148 187 5718022 SGTC_2522 biochanin a 4.94 µM 0.97392680035791 0.22691585659783 no 796 0.165046442842236 178 5280373 A possible chelator. SGTC_678 1218-2179 85.9 µM 0.973914646034579 0.226918476437 no 797 0.165049460514062 205 6820081 YOR116C RPO31 SGTC_1654 st012436 41.8 µM 0.971782757638581 0.227378264403058 no 798 0.16557931774525 187 4323132 SGTC_2289 7946404 165.07 µM 0.970261369698949 0.227706705371818 no 799 0.165958113764571 194 1246120 YPR165W RHO1 SGTC_1462 k081-0014 26.5 µM 0.968479491058617 0.228091721040887 no 800 0.166402478386428 159 3270634 SGTC_2174 5790901 200 µM 0.968007577838833 0.228193749977646 no 801 0.166520292586458 188 786020 SGTC_1362 1611-0397 101 µM 0.967621497535065 0.228277240681103 no 802 0.166616718440913 190 27816 SGTC_1841 st054148 70 µM 0.966801688705299 0.228454583046387 no 803 0.166821590055103 195 675442 SGTC_1025 k007-0731 70 µM 0.964446457579838 0.22896450082041 no 804 0.167411069982949 175 6256118 SGTC_2921 7974240 10.71 µM 0.964186906615181 0.229020733773158 no 805 0.16747611380407 187 2979074 YDR527W RBA50 SGTC_2496 diffractaic acid 79.83 µM 0.962415808604452 0.229404657352225 no 806 0.167920387890108 188 94870 An apoptosis inducer which activates caspases. SGTC_111 0083-0039 52.457 µM 0.961516354738086 0.229599771352407 no 807 0.168146303123883 156 759313 SGTC_1467 k284-1082 293 µM 0.960419276359313 0.22983788084299 no 808 0.168422120177772 196 3334705 SGTC_1163 k060-0048 49.9 µM 0.959514381170825 0.230034382965272 no 809 0.168649839181964 184 6809982 SGTC_750 4073-0104 132 µM 0.95938829570559 0.230061770460196 no 810 0.168681584587389 161 22330957 SGTC_1643 st009866 20.2 µM 0.958331742169039 0.230291340090588 no 811 0.168947751260809 188 3156273 YOR207C RET1 SGTC_391 gliotoxin 8.33 µM 0.956072133413943 0.23078274116641 no 812 0.16951789621505 191 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_549 1661-1316 519 µM 0.952243266663526 0.231616746932303 no 813 0.17048681142417 216 2857282 SGTC_1432 4049-0298 68.4 µM 0.952155741362058 0.231635831357392 no 814 0.170509001550505 191 741646 SGTC_905 2-aminofluorene 215 µM 0.950725219170643 0.231947873274372 no 815 0.170871941281582 192 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2364 9055074 200 µM 0.949910517035578 0.232125690019958 no 816 0.171078861232283 178 6470630 SGTC_707 0865-0008 204 µM 0.945224020097794 0.233150036278431 no 817 0.172272259459849 207 723043 SGTC_1996 st072960 66.8 µM 0.942915044969083 0.233655639437426 no 818 0.172862179403729 194 1719405 SGTC_2464 5717415 7.67 µM 0.942637870840683 0.23371637392118 no 819 0.172933081051406 191 5285744 SGTC_301 4119-0100 24.5 µM 0.940002494423016 0.234294275403694 no 820 0.173608140591475 203 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2962 9082311 13.18 µM 0.93981726465585 0.234334923449709 no 821 0.173655650733992 206 16459453 SGTC_3227 9130768 49.47 µM 0.935507714755806 0.235281740559174 no 822 0.174763354693584 192 17720899 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.93494939021242 0.23540455997843 no 823 0.174907190965879 180 5379071 SGTC_1325 1431-0015 227 µM 0.9342824118171 0.235551327286121 no 824 0.17507911722826 172 1103340 SGTC_3181 9108277 49.47 µM 0.933789453770426 0.235659834188434 no 825 0.175206255338276 204 17097298 SGTC_1214 0358-0031 63.7 µM 0.933434971610845 0.23573787766433 no 826 0.175297715510694 194 4301366 SGTC_2431 5490079 200 µM 0.933006947748682 0.235832131214353 no 827 0.175408190563915 219 5722345 SGTC_948 3448-0295 75.3 µM 0.931799575263229 0.236098114162463 no 828 0.175720057096363 194 678569 SGTC_1505 k297-0037 20.6 µM 0.929704903403127 0.236559960100829 no 829 0.176261947496329 191 4089396 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.928184751200481 0.23689544351788 no 830 0.176655871477566 209 229346 A bile salt which induces apoptosis. SGTC_1384 3089-0840 101 µM 0.926467979977541 0.237274633208963 no 831 0.177101415013163 167 1069836 SGTC_984 1492-0255 2.91 µM 0.926420204290576 0.23728519036925 no 832 0.17711382409993 201 1585198 SGTC_237 nikkomycin 200 µM 0.922206061878173 0.238217418373305 no 833 0.178210550875222 206 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1188 1403-0014 4.57 µM 0.921063303541691 0.238470558099131 no 834 0.178508688863339 199 9614867 SGTC_2493 resveratrol 26.09 µM 0.91630127249306 0.239527009978398 no 835 0.179754450394255 176 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3101 9120531 49.47 µM 0.915215400807573 0.239768266802328 no 836 0.180039280571537 209 24824904 SGTC_1930 st074634 34.3 µM 0.914130202657734 0.240009506381497 no 837 0.180324217019997 199 684253 YOR116C RPO31 SGTC_1431 4049-0260 9.09 µM 0.91278276158657 0.240309226661333 no 838 0.1806784031804 221 3854841 SGTC_1943 st076331 65.2 µM 0.911808140543062 0.24052614513254 no 839 0.180934862149492 198 24208415 SGTC_1515 3460-0031 42.1 µM 0.909625585874556 0.2410122962339 no 840 0.181510000238315 205 2876596 SGTC_774 k060-0086 136 µM 0.908724298542593 0.241213208421004 no 841 0.181747837349679 202 5911235 SGTC_2440 5628896 157.78 µM 0.908565488481837 0.24124861929974 no 842 0.181789765296663 213 5522048 SGTC_362 0310-0100 9.03 µM 0.907644382348841 0.241454059833489 no 843 0.182033068749177 196 790235 SGTC_1280 0880-0253 10.1 µM 0.904357555311983 0.242187917019241 no 844 0.182902918468486 221 6836607 SGTC_1281 0884-0031 11.8 µM 0.904326873384556 0.242194773132868 no 845 0.182911050557522 220 1548255 SGTC_2097 5376186 200 µM 0.903531737782137 0.242372489013144 no 846 0.183121875901369 208 742755 SGTC_346 4513-0042 7.16 µM 0.902335245490207 0.242640042765405 no 847 0.183439404051352 205 2827372 SGTC_1868 st057644 42.7 µM 0.901358119831972 0.242858661393053 no 848 0.18369897056906 193 688665 SGTC_3019 9081971 49.47 µM 0.900848413967553 0.242972743462212 no 849 0.183834461097743 192 16451803 SGTC_2332 7982454 138.89 µM 0.898175709255943 0.243571420936224 no 850 0.184545940647548 233 2981748 SGTC_1294 1000-1494 117 µM 0.897162636146391 0.243798554182938 no 851 0.1848160697926 177 712797 YDL207W GLE1 SGTC_218 alverine citrate 93.75 µM 0.890420707670577 0.245313017264753 no 852 0.186620013681571 209 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2195 6536160 144.242 µM 0.890065773128889 0.245392887341436 no 853 0.186715284955273 198 3834386 SGTC_2786 7743617 45.45 µM 0.8843302315979 0.246685478004507 no 854 0.188258986602175 196 583674 SGTC_1140 3229-1848 2.98 µM 0.883405627818715 0.246894192129403 no 855 0.188508575585784 214 2849525 SGTC_2154 5570129 200 µM 0.88315922286019 0.246949829949328 no 856 0.188575124943931 232 673366 SGTC_1506 4226-2149 212 µM 0.882059968007904 0.24719812153343 no 857 0.188872189486108 204 991114 SGTC_177 1327-0068 8.361 µM 0.881743196722054 0.247269696266927 no 858 0.188957847799558 220 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2790 5423970 71.43 µM 0.879527526740631 0.247770638372093 no 859 0.189557657363939 213 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1359 1582-0056 520 nM 0.878873239221157 0.247918670177907 no 860 0.189735004971837 212 3661189 SGTC_2873 9040596 71.43 µM 0.877025624704006 0.248336945573985 no 861 0.190236359989128 226 6463863 SGTC_400 oxethazaine 37.5 µM 0.874486781804876 0.248912318972404 no 862 0.190926607776409 216 4621 A local anesthetic. SGTC_475 α-linolenic acid 10 µM 0.874028117755536 0.24901634079778 no 863 0.191051470689961 217 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2564 betulinic acid 100 µM 0.869850582206787 0.249964840672808 no 864 0.192191032337187 213 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_468 gf-109203x 121 µM 0.869841272353044 0.249966956592793 no 865 0.192193576543856 177 2396 A protein kinase C inhibitor. SGTC_832 4083-0019 164 µM 0.868268577614421 0.250324531052659 no 866 0.192623659895657 233 1990758 SGTC_1578 josamycin 24.2 µM 0.867888837103498 0.250410911070982 no 867 0.192727595269196 223 5282165 A P450 substrate. SGTC_1154 4088-0362 150 µM 0.86434090840528 0.251218725321597 no 868 0.193700321908284 221 6618304 SGTC_548 1436-0017 110 µM 0.863732028199106 0.251357497331614 no 869 0.193867557491481 203 9677137 SGTC_197 4544-0043 41.561 µM 0.863203437008019 0.251478003243962 no 870 0.194012812160312 227 896523 SGTC_1142 3253-1408 9.78 µM 0.862649224662237 0.251604382932979 no 871 0.194165178605983 218 256655 SGTC_2520 obtusaquinone 4.71 µM 0.862128794619368 0.251723089620143 no 872 0.194308323811354 218 5967872 SGTC_849 0386-0493 241 µM 0.86116686422101 0.251942577477815 no 873 0.194573073567382 228 726119 SGTC_1018 4259-0013 28.1 µM 0.85914409321789 0.252404451264368 no 874 0.195130511593222 220 6801262 SGTC_1416 3966-0321 25.3 µM 0.859114728826432 0.252411159530926 no 875 0.195138611014077 221 582530 YLR208W SEC13 SGTC_3126 9127922 49.47 µM 0.857586833677994 0.252760335292715 no 876 0.19556032391654 261 45595682 SGTC_3060 1327-0027 12.5 µM 0.855072815308178 0.253335426657461 no 877 0.196255419042813 211 16000455 YPR107C YTH1 SGTC_1420 4'-methoxyflavone 42 µM 0.854968085361062 0.253359398950493 no 878 0.19628440804683 215 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1961 st076550 68.7 µM 0.854959997348248 0.253361250315961 no 879 0.196286646897806 234 1579337 SGTC_743 1275-0778 158 µM 0.852861377838754 0.253841869540987 no 880 0.196868090928249 244 2849257 YMR203W TOM40 SGTC_2959 9079155 11 µM 0.852358247671597 0.253957165907572 no 881 0.197007643115821 220 16189457 SGTC_761 k216-0224 480 µM 0.851774266591633 0.254091024369115 no 882 0.197169695816411 234 1340404 SGTC_3124 9127567 49.47 µM 0.850752014786605 0.254325431050443 no 883 0.197453561196622 182 17592030 SGTC_1655 st012546 55.1 µM 0.849325911139685 0.254652631954692 no 884 0.19784998331777 208 720985 YLR208W SEC13 SGTC_2461 5755302 26.15 µM 0.849303550487039 0.254657764070058 no 885 0.197856202861488 235 2788904 SGTC_2341 7987486 176.74 µM 0.849275658782549 0.254664165723226 no 886 0.197863961015067 206 1258686 SGTC_2021 4019055 173 µM 0.848518936306125 0.254837879441728 no 887 0.198074515556913 250 44827708 YER133W GLC7 SGTC_471 1-acyl-paf 4 µM 0.848039695052061 0.254947926455551 no 888 0.198207932174848 211 16759367 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.846887579449904 0.255212585697497 no 889 0.198528893081087 215 61125 An anti-inflammatory. SGTC_2284 7945075 39.21 µM 0.846052257914476 0.255404562110707 no 890 0.198761796188726 245 1245402 SGTC_3007 9078383 71.4286 µM 0.839542921169975 0.256903141280823 no 891 0.200582357079483 221 6496995 SGTC_859 0439-0102 54.6 µM 0.839103096928375 0.257004562359524 no 892 0.200705729193294 243 610143 SGTC_1293 1000-1278 195 µM 0.838354557374234 0.257177219386755 no 893 0.200915801646007 236 678847 SGTC_446 go6976 132 µM 0.838020134171352 0.257254376434556 no 894 0.201009697827294 227 3501 A protein kinase C inhibitor. SGTC_924 2046-0044 21.3 µM 0.837193879953793 0.257445058733337 no 895 0.201241798498412 217 3623589 SGTC_1256 0570-0116 285 µM 0.836173717714119 0.257680592233489 no 896 0.201528590871807 224 410638 SGTC_2895 9054447 58.44 µM 0.834997185672872 0.257952367001867 no 897 0.201859646482044 238 2697450 SGTC_123 0083-0120 66.675 µM 0.829640216789695 0.259191685288946 no 898 0.203371115741808 254 16001701 SGTC_976 1348-1067 47.6 µM 0.826572056207436 0.259902878471967 no 899 0.204239830612134 232 5310671 YGL099W LSG1 SGTC_1203 3992-3522 103 µM 0.826183352893692 0.259993050872129 no 900 0.204350045035592 242 5322312 SGTC_2031 5180455 200 µM 0.825842046886276 0.260072241222999 no 901 0.204446849434101 231 29949 SGTC_451 chloral hydrate 100 µM 0.825417318787474 0.260170804661053 no 902 0.204567352895097 233 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2476 5806916 10.51 µM 0.825244584757204 0.260210895247831 no 903 0.204616372920221 227 2870194 SGTC_3146 9095609 49.47 µM 0.822749411975714 0.260790365626087 no 904 0.205325254943371 229 17173999 SGTC_1255 0566-0045 221 µM 0.822521476309255 0.260843333699773 no 905 0.205390084417888 229 2788469 SGTC_2839 9003951 25.97 µM 0.821758558184949 0.261020662148836 no 906 0.205607162056872 218 2990634 SGTC_2419 paclitaxel 166.5 µM 0.821177297991955 0.261155808626447 no 907 0.205772642857014 237 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2770 toltrazuril 17.5 µM 0.819486426007009 0.261549150856488 no 908 0.206254471668563 209 68591 Kills coccidiodes. SGTC_2397 5161689 200 µM 0.819443101740789 0.261559233238748 no 909 0.206266826078954 240 2259942 SGTC_213 1246-0773 967 nM 0.817251684110707 0.26206947801889 no 910 0.206892305923231 222 6251622 SGTC_1342 1486-1464 234 µM 0.812779317123958 0.263112394714618 no 911 0.208172297950945 247 3253938 SGTC_801 0866-0028 10.1 µM 0.812160130863096 0.263256950457064 no 912 0.208349876682506 237 6849771 SGTC_1390 3413-2614 145 µM 0.811558612364292 0.263397420302521 no 913 0.208522473947294 259 3421432 SGTC_775 4577-0580 57.3 µM 0.811099951373737 0.263504554998979 no 914 0.208654136893148 224 2006902 SGTC_3112 9123419 49.47 µM 0.810519545717288 0.263640158861361 no 915 0.208820818009575 258 17015854 SGTC_2683 piperine 63.03 µM 0.810223982151416 0.263709226934 no 916 0.208905728206761 239 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1539 benzyladenosine 56 µM 0.810220389881012 0.263710066441975 no 917 0.208906760327751 220 92208 A nucleotide analog. SGTC_2597 laccaic acid a 100 µM 0.80796106383487 0.26423833730292 no 918 0.209556498408713 227 5491415 A textile dye. SGTC_2343 7990716 14.84 µM 0.80649974811198 0.264580305847678 no 919 0.209977376600261 254 6456862 SGTC_352 k048-0007 5.11 µM 0.804770827095905 0.264985188379356 no 920 0.210475969593218 261 6811911 SGTC_1727 st034309 9.9045 µM 0.804484715782168 0.265052220903917 no 921 0.21055854645225 245 870305 SGTC_2057 5236571 38.335 µM 0.802690284919774 0.265472831350504 no 922 0.211076884777314 215 54684039 YBR257W POP4 SGTC_973 1325-0077 65.9 µM 0.802564463820062 0.26550233622558 no 923 0.211113257429183 228 2835149 SGTC_1425 4048-4433 7.33 µM 0.80210972351435 0.265608986072494 no 924 0.211244745424504 272 23734946 SGTC_450 aminopyrene 156 nM 0.801650791853988 0.26571664093793 no 925 0.211377493982925 244 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2819 7996655 46.38 µM 0.800855669171445 0.265903210875696 no 926 0.211607603304702 213 6456960 SGTC_1743 st037606 46.3785 µM 0.800505181821953 0.265985471337057 no 927 0.211709081251927 200 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3269 9137823 49.47 µM 0.797856995487042 0.266607425236788 no 928 0.212476740876501 194 17682936 SGTC_742 0kpi-0133 140 µM 0.797260242231423 0.266747680354606 no 929 0.212649952708335 247 2728852 SGTC_3030 9087619 49.47 µM 0.797079201834377 0.266790237711485 no 930 0.212702517255167 245 25236973 SGTC_1620 st003704 16.5 µM 0.796576094062033 0.266908521799393 no 931 0.212848632947179 237 2834414 SGTC_477 mead ethanolamide 10 µM 0.796311365164444 0.266970772014624 no 932 0.212925540680353 196 16061185 SGTC_3066 9117245 49.47 µM 0.795511268948532 0.267158956828433 no 933 0.213158079234376 229 17176980 SGTC_110 0850-0284 111.64 µM 0.795267506370802 0.267216303756971 no 934 0.213228955387828 216 3906265 SGTC_3003 9075612 71.4286 µM 0.794514188050908 0.267393566657197 no 935 0.213448076281336 256 6501993 SGTC_1262 0737-0114 49.6 µM 0.793709625099306 0.26758295338532 no 936 0.213682247794584 248 765919 SGTC_2644 guaiazulene 100 µM 0.791567750894848 0.26808746031483 no 937 0.214306378538601 221 3515 A coloring agent. SGTC_999 SEC7.066 22.7 µM 0.790217266490643 0.268405805575478 no 938 0.214700446972056 242 740511 YDR170C SEC7 SGTC_255 tunicamycin 200.472 nM 0.789205759028328 0.268644369362644 no 939 0.21499587827962 228 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1191 1487-1166 10.6 µM 0.785990746588737 0.269403336116373 no 940 0.215936454140133 257 3955771 SGTC_769 0302-0231 76 µM 0.785175473241812 0.269595968100666 no 941 0.216175346840076 263 571869 YER009W NTF2 SGTC_1221 2958-7315 257 µM 0.785158978207595 0.269599866243273 no 942 0.216180181820401 244 4562705 SGTC_3018 9082602 49.47 µM 0.784264846436154 0.269811211666583 no 943 0.216442361015567 249 17332089 SGTC_2735 sertaconazole 140 nM 0.782875462801212 0.270139784014045 no 944 0.216850123900802 269 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2846 9008642 19.48 µM 0.779054676414086 0.271044384316496 no 945 0.21797375362629 273 2992898 SGTC_858 0438-0351 2.77 µM 0.775908202476451 0.271790468786376 no 946 0.218901594577449 250 2799119 SGTC_2277 7947813 106.88 µM 0.772246009440315 0.272660124412643 no 947 0.219984367983392 236 1246798 SGTC_550 4123-0385 25.7 µM 0.770654346160185 0.273038524438526 no 948 0.220455919601392 240 5731123 SGTC_2626 ethyl orsellinate 100 µM 0.769349230407655 0.273348995133416 no 949 0.220843009544053 265 75653 A natural product. SGTC_2898 9056270 58.44 µM 0.768037244029821 0.27366127637697 no 950 0.221232529219118 200 19154699 SGTC_1208 2323-2347 50.3 µM 0.765843676606526 0.274183786982308 no 951 0.221884661226863 248 5412760 SGTC_390 dec-rvkr-cmk 16.7 µM 0.76148877853032 0.275222587376873 no 952 0.223182589412783 232 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3194 9111903 49.47 µM 0.759717794815678 0.275645584408856 no 953 0.223711644824296 242 17087251 SGTC_680 0417-1641 114 µM 0.759323801254335 0.275739732675697 no 954 0.223829441506967 244 2835990 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.758739883158753 0.275879294162734 no 955 0.224004086886921 263 2346 DNA damaging agent; causes G2/M arrest. SGTC_1241 0364-0022 50.8 µM 0.758533486499004 0.275928633053363 no 956 0.2240658370432 246 4563895 SGTC_1243 0416-0003 5.65 µM 0.757407416712762 0.276197895082638 no 957 0.224402907043722 252 2141977 SGTC_1748 st037455 53.6035 µM 0.753665620864977 0.277093545847087 no 958 0.225525015168333 255 580690 SGTC_411 enrofloxacin 100 µM 0.750454500605951 0.277863303598208 no 959 0.226490508560865 232 71188 A bacterial gyrase inhibitor. SGTC_3210 9128157 49.47 µM 0.742920258917309 0.279673471323182 no 960 0.228764979764051 245 17590849 SGTC_1261 0712-0010 12.7 µM 0.742662615416016 0.279735473497423 no 961 0.22884298443879 257 2840123 SGTC_1857 st056007 79.3 µM 0.738265427999948 0.280794688196727 no 962 0.230176585345126 247 619834 SGTC_805 3852-0218 479 µM 0.737821102804065 0.280901827080775 no 963 0.23031158392376 240 6615355 SGTC_2127 5253358 187.912 µM 0.735141367058049 0.281548402839607 no 964 0.231126701600607 242 20612 SGTC_1772 st048439 82.2 µM 0.735141185649223 0.281548446634835 no 965 0.23112675683569 247 2927068 YDL195W SEC31 SGTC_2638 epoxomicin 18 µM 0.731160466313319 0.282510251420841 no 966 0.232340572252049 252 9915668 A protesome inhibitor. SGTC_2237 6667747 47.222 µM 0.729629071415932 0.282880680989269 no 967 0.232808473590632 264 729940 YDL015C TSC13 SGTC_2060 5238662 140 µM 0.728612004772003 0.283126828374948 no 968 0.233119516536077 268 790130 SGTC_184 1494-0393 24.714 µM 0.72471189235493 0.284071673255758 no 969 0.23431439891342 272 3090647 SGTC_294 k038-0071 157 µM 0.721496262190547 0.284851827512848 no 970 0.235302119778883 266 24152826 SGTC_2179 6298986 200 µM 0.718506452920368 0.285578110442055 no 971 0.236222535266521 250 738374 SGTC_3168 9103419 49.47 µM 0.716485764277987 0.286069473680361 no 972 0.236845727290317 262 16649256 SGTC_1929 genistein trimethyl ether 50.5 µM 0.711131105596102 0.287373484889576 no 973 0.238501498029066 255 136420 SGTC_413 propylparaben 100 µM 0.710822304766598 0.287448772325071 no 974 0.238597178482719 261 7175 A pharmaceutical preservative. SGTC_1316 1272-0050 65.9 µM 0.710760261681785 0.287463899914754 no 975 0.238616404768668 280 7340392 SGTC_155 k072-0202 43.6 µM 0.71020660203335 0.287598912062305 no 976 0.238788013703237 274 5857737 SGTC_1379 2144-0755 36.5 µM 0.709109959661175 0.287866421192823 no 977 0.239128121428334 284 5392327 SGTC_1340 1486-1359 257 µM 0.70875319424815 0.287953473983754 no 978 0.239238824095512 270 4309068 SGTC_1419 3993-2473 62.6 µM 0.706593136920524 0.288480805514332 no 979 0.239909677577876 282 704026 SGTC_3169 9102970 49.47 µM 0.700808071110166 0.289895341990939 no 980 0.241711400217811 276 17027839 SGTC_1089 terbinafine 2.25 µM 0.699506425248932 0.290214061917259 no 981 0.242117799501834 277 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_78 0336-0123 156.75 µM 0.696847064898846 0.290865740494943 no 982 0.242949254216594 260 6765896 SGTC_1285 0929-0069 65.5 µM 0.695844916447939 0.291111495172728 no 983 0.243262978336644 260 1206237 SGTC_2205 7238770 200 µM 0.695465416236138 0.291204584489456 no 984 0.243381838602114 266 279867 SGTC_1843 st055809 45.5 µM 0.691935290126001 0.292071170187667 no 985 0.244488983683144 270 16413835 SGTC_2691 st077356 60.2 µM 0.690741358284049 0.292364531481138 no 986 0.244864046793113 291 2839272 SGTC_2909 7941780 10.49 µM 0.688355511353682 0.292951168624742 no 987 0.24561446620627 262 1243215 SGTC_811 0416-0114 265 µM 0.687346927907979 0.293199325432536 no 988 0.245932066575093 270 6612453 SGTC_2130 NSC 7 2.4545 µM 0.68481510422675 0.293822696732859 no 989 0.246730301454946 258 21448 SGTC_2196 6573537 42.6665 µM 0.682942575217886 0.29428413428984 no 990 0.24732156477172 291 2903087 SGTC_2537 larixol 68.93 µM 0.681337037685416 0.294680044846743 no 991 0.247829126300369 280 6708759 SGTC_2842 9000675 19.48 µM 0.678338802144631 0.295420038684994 no 992 0.248778450828066 271 2989072 SGTC_296 1222-0039 74.9 µM 0.678180431258804 0.295459149925519 no 993 0.248828649224031 265 5984176 SGTC_89 0302-0250 142.109 µM 0.677235164859139 0.29569264223037 no 994 0.249128379895322 286 4203518 YLR208W SEC13 SGTC_2052 5265182 7.135 µM 0.674956028374578 0.296255965102 no 995 0.249851851021526 265 1239884 SGTC_2831 7999036 19.48 µM 0.666738325660665 0.298291168834447 no 996 0.252469646771013 280 2988270 SGTC_2091 4-phenylthiadiazole 200 µM 0.665384363039624 0.298627102333897 no 997 0.252902341910356 279 270010 SGTC_2357 9067248 200 µM 0.664689547449937 0.298799560739897 no 998 0.253124540349235 295 9150235 SGTC_527 4476-4215 268 µM 0.66319136684636 0.299171574253607 no 999 0.253603999964953 268 4418754 SGTC_1531 st059297 52.4 µM 0.662768214441809 0.29927668536586 no 1000 0.253739506893177 284 7566702 SGTC_32 0928-0142 34.1 µM 0.657559686380224 0.300571854274881 no 1001 0.255410553101673 287 2244242 SGTC_2767 sibutramine 71.45 µM 0.655797342193876 0.30101065662831 no 1002 0.255977263370552 283 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2281 7943571 200 µM 0.655548273436946 0.301072695015009 no 1003 0.256057408334197 280 1244024 SGTC_3162 9099653 49.47 µM 0.654661259045435 0.301293680562572 no 1004 0.256342936742494 255 25237511 SGTC_417 st075190 100 µM 0.653564020277012 0.301567141188912 no 1005 0.25669636547435 293 222757 SGTC_815 1582-0027 36.9 µM 0.651707258778001 0.30203014891538 no 1006 0.257295019512134 300 3128206 SGTC_115 0527-0192 112.043 µM 0.650902041252994 0.30223103961683 no 1007 0.257554861845252 310 4233931 SGTC_66 0109-0187 42.4 µM 0.650242519118248 0.30239562597799 no 1008 0.257767790008054 271 759417 SGTC_1714 st033236 13.627 µM 0.649463100745784 0.302590184726045 no 1009 0.258019544677679 294 2916566 SGTC_478 N-arachidonylglycine 10 µM 0.649226932910605 0.302649148115038 no 1010 0.258095852824665 254 5283389 SGTC_3059 1327-0034 3 µM 0.648633963061861 0.302797215989501 no 1011 0.258287498772411 282 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1230 0170-0365 3.77 µM 0.646523729610395 0.30332441598005 no 1012 0.258970117204451 286 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1295 1013-0063 9.78 µM 0.645325382169108 0.303623981845712 no 1013 0.259358173693893 288 6826038 SGTC_615 k087-0205 167 µM 0.639793714113464 0.305008510534513 no 1014 0.261153359876357 295 9642773 SGTC_2090 5301565 104.445 µM 0.638305850819285 0.305381387833573 no 1015 0.261637302057422 295 2056344 SGTC_1412 3909-8563 178 µM 0.637781692809913 0.305512796578284 no 1016 0.261807899171072 312 23767530 SGTC_1666 st014829 29 µM 0.637694437572327 0.305534674287927 no 1017 0.261836303573142 291 3858230 SGTC_652 0437-0092 114 µM 0.637652394108391 0.305545216191803 no 1018 0.261849990644804 276 3091274 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.637027902584258 0.305701819070368 no 1019 0.262053334412156 301 91467 include heat shock SGTC_3327 9140648 26.9345 µM 0.636598611364089 0.305809492454335 no 1020 0.262193164974912 313 8029710 SGTC_262 fenpropimorph 62.5 µM 0.636138483207897 0.305924918896141 no 1021 0.262343082310882 310 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_654 1124-0271 80.9 µM 0.635912268893902 0.305981673445443 no 1022 0.262416802755797 291 5403748 SGTC_3139 9095020 49.47 µM 0.633939552555382 0.30647680243607 no 1023 0.26306013586059 255 25236292 SGTC_2375 9072683 200 µM 0.633844711714852 0.306500615303233 no 1024 0.26309108520983 295 16798029 SGTC_3352 9151559 45.5865 µM 0.633630625391531 0.30655437161777 no 1025 0.263160954699117 274 17159339 SGTC_2073 5212005 126 µM 0.630524846694904 0.307334689323979 no 1026 0.264175625844362 301 691789 SGTC_2027 5150920 200 µM 0.625426140746314 0.308617616074232 no 1027 0.265845704913948 284 786715 SGTC_334 1502-1024 68.5 µM 0.625145346243002 0.308688337168364 no 1028 0.265937834251354 298 3296216 SGTC_2374 9071832 200 µM 0.624605706159696 0.308824271207492 no 1029 0.266114936838437 286 17381698 SGTC_814 3342-0569 96 µM 0.622422536822031 0.309374473498247 no 1030 0.266832032564026 304 4346283 SGTC_2381 9035592 200 µM 0.622328346280944 0.309398221028227 no 1031 0.266862992860816 291 4749657 SGTC_3176 9106582 49.47 µM 0.621652511048714 0.309568637461985 no 1032 0.267085192158282 270 17018027 SGTC_602 3130-1533 38.1 µM 0.619179517801077 0.310192568342543 no 1033 0.267899051727446 313 720941 SGTC_894 0960-0238 55.9 µM 0.619098849069011 0.310212930108692 no 1034 0.267925620746604 306 6741907 YDL195W SEC31 SGTC_2956 9076196 2.52 µM 0.61599274165026 0.310997391327794 no 1035 0.268949655148673 319 16423868 SGTC_1644 st010134 20.9 µM 0.615375506706581 0.311153379242111 no 1036 0.269153381508887 303 3818134 SGTC_836 0330-0104 1.35 µM 0.615134836657895 0.311214210687968 no 1037 0.269232838740121 289 46494820 SGTC_2251 lansoprazole 556 µM 0.61464985019788 0.311336810893802 no 1038 0.269392992785672 309 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1921 5740136 50 µM 0.614632659948823 0.311341156817948 no 1039 0.26939867029046 315 1774243 SGTC_2863 9028737 58.44 µM 0.614413149724266 0.311396654240652 no 1040 0.269471174242975 305 6460917 SGTC_3017 9080681 49.47 µM 0.612892464255369 0.3117812374586 no 1041 0.269973723169557 323 16451914 SGTC_2690 usnic acid 100 µM 0.611753145972265 0.3120695070349 no 1042 0.270350546775572 315 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1423 4048-0112 5.59 µM 0.607321244621977 0.31319195749835 no 1043 0.271818871117151 296 X1423 SGTC_1319 1306-0155 43.7 µM 0.604094295931671 0.314010325389514 no 1044 0.272890475826567 305 3122360 SGTC_1696 st025591 34.7925 µM 0.603197124894221 0.314238014602635 no 1045 0.273188780063409 293 2787147 SGTC_1024 4507-0395 26 µM 0.600648571636454 0.314885186552906 no 1046 0.274037039784558 295 4201836 SGTC_578 3460-0051 92 µM 0.59877497858235 0.315361324103591 no 1047 0.274661474978908 328 2876744 SGTC_913 3487-1245 167 µM 0.598513146970192 0.315427888010135 no 1048 0.274748794644629 287 4016153 SGTC_1933 st074711 15.9 µM 0.597427411947799 0.31570397192484 no 1049 0.275111028381089 300 17250958 SGTC_1572 epiandrosterone 68.9 µM 0.597286244991655 0.31573987583664 no 1050 0.275158143179926 301 441302 A steroid. SGTC_2409 alverine citrate 63.97 µM 0.595514643083092 0.316190606645544 no 1051 0.275749756997636 269 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_778 3456-2434 196 µM 0.595430804532585 0.316211943619914 no 1052 0.275777769768706 280 5539063 SGTC_2611 pyromycin 23.93 µM 0.594885686858008 0.316350691403325 no 1053 0.27595994271279 291 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2886 9058944 51.95 µM 0.594870377435041 0.316354588455526 no 1054 0.275965059823929 263 4949929 SGTC_2253 7938677 135.83 µM 0.594363361544587 0.316483662148151 no 1055 0.276134554106372 292 2301972 SGTC_1040 k898-0338 155 µM 0.593592923441373 0.316679839405052 no 1056 0.276392207630377 325 20969351 SGTC_269 exalamide 29 µM 0.591863749056059 0.31712032813652 no 1057 0.276970915197948 299 3316 A derivative of salicylamide. SGTC_2646 retinol 96.75 µM 0.591456062120708 0.31722421982516 no 1058 0.277107443277559 317 445354 A vitamin A analog and teratogen. SGTC_1879 gemcitabine 100 µM 0.591251536786546 0.317276344857542 no 1059 0.277175948066806 333 60750 A nucleoside analog which inhibits DNA replication. SGTC_1806 st050005 60.3 µM 0.590158699081694 0.317554925308684 no 1060 0.277542129217211 285 5194765 SGTC_2561 acetosyringone 100 µM 0.589383026575418 0.317752718394044 no 1061 0.277802180022851 329 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2988 9073640 71.4286 µM 0.58931843591307 0.317769191076454 no 1062 0.277823839956519 319 9102229 SGTC_828 2074-0507 139 µM 0.587602180812779 0.318207022993106 no 1063 0.278399673451761 298 X828 SGTC_949 1165-0505 146 µM 0.586133129397663 0.318581992947045 no 1064 0.278893027349181 296 6244267 SGTC_228 caffeine 993.056 µM 0.585900990125452 0.318641262655626 no 1065 0.278971025956447 283 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3144 9087057 49.47 µM 0.584665152546239 0.318956874303227 no 1066 0.279386444898162 327 17249618 SGTC_1022 4477-0945 21.3 µM 0.583309967599587 0.319303116165188 no 1067 0.279842326849432 300 4648966 SGTC_711 k292-0785 179 µM 0.582861062571552 0.319417843559847 no 1068 0.279993417266904 301 4146315 SGTC_606 k015-0008 38.6 µM 0.57882094405793 0.320451160212219 no 1069 0.281354998787851 321 1970475 SGTC_1573 oleylamine 1.06 µM 0.577664470944034 0.320747201210601 no 1070 0.281745335350802 316 5356789 An amine of the fatty acid oleic acid. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.576462316894691 0.32105505677609 no 1071 0.282151366798532 311 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_659 k018-0002 107 µM 0.575110636265165 0.3214013510481 no 1072 0.282608237485666 322 6797879 YHR007C ERG11 SGTC_1641 st009299 47.1 µM 0.574901766849038 0.32145487627849 no 1073 0.282678867462338 305 4046054 SGTC_3134 9127454 49.47 µM 0.574369393020971 0.321591320063541 no 1074 0.282858930025016 325 24262820 SGTC_278 4092-0821 23.9 µM 0.570309547952296 0.322632621267219 no 1075 0.284233883071767 306 877900 SGTC_2806 7952793 58.44 µM 0.569379069256053 0.322871474267826 no 1076 0.28454945901333 314 2972490 SGTC_2640 pentamidine 10.38 µM 0.567933828239446 0.32324261115608 no 1077 0.285039950395659 313 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1559 coumarin 343 70.1 µM 0.566878885120813 0.323513630959264 no 1078 0.285398235330431 323 108770 A hepatotoxic, DNA x-linker. SGTC_3028 9087778 49.47 µM 0.566147146778308 0.323701672968041 no 1079 0.285646877787084 306 17217395 SGTC_377 3970-0964 33.1 µM 0.566087740267044 0.323716941220703 no 1080 0.285667068461281 302 16481235 SGTC_518 1021-0119 62.6 µM 0.563573282184881 0.324363461709791 no 1081 0.286522287070219 311 1097762 SGTC_2536 dehydroabietamide 32.04 µM 0.563147634942397 0.324472957129054 no 1082 0.286667178527619 315 3983547 SGTC_323 4013-0906 34.3 µM 0.563106564286845 0.324483523132963 no 1083 0.286681160926156 289 2910086 SGTC_1448 4255-0083 152 µM 0.56064938348859 0.325115924295621 no 1084 0.287518289624937 347 5399660 SGTC_2165 5727197 32.143 µM 0.558056674316763 0.325783752837557 no 1085 0.288402842232634 333 1361712 SGTC_962 1254-0300 21.5 µM 0.557589019294912 0.325904270764944 no 1086 0.288562528200794 313 7340576 SGTC_2975 9084847 53.72 µM 0.555446645931503 0.326456607575559 no 1087 0.289294597241614 294 27211724 SGTC_1401 3807-4679 7.6 µM 0.553938342173504 0.326845699949669 no 1088 0.289810521763315 327 3291456 SGTC_1222 0366-0074 1.18 µM 0.553858449598616 0.326866314842065 no 1089 0.289837861540146 351 286520 SGTC_2210 7115885 190.385 µM 0.552210889911982 0.32729155676345 no 1090 0.290401937097598 329 2927039 SGTC_2744 captopril 92.04 µM 0.550498944179552 0.327733654561702 no 1091 0.290988600430843 287 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3324 9138759 60.749 µM 0.549855700127081 0.327899830232192 no 1092 0.291209175506681 335 45595710 SGTC_3122 9126309 49.47 µM 0.548338415609764 0.328291940476947 no 1093 0.291729777137271 344 17591206 SGTC_1785 bathophenanthroline 24 µM 0.545822331996882 0.328942586280227 no 1094 0.292594035421316 309 72812 An iron chelator. SGTC_2983 9022671 12.99 µM 0.544519998160879 0.329279566711423 no 1095 0.293041845320363 342 6405161 SGTC_3318 9139014 38.6185 µM 0.543977622536473 0.329419947986324 no 1096 0.293228435912477 331 16643984 SGTC_583 1488-1091 88.9 µM 0.540525700625788 0.330313960260317 no 1097 0.294417270911932 337 4303273 SGTC_3178 9107506 49.47 µM 0.540144609757625 0.330412718389619 no 1098 0.294548654115132 324 8897194 SGTC_1771 st048882 4.1505 µM 0.53844924948379 0.330852207104114 no 1099 0.29513346664896 312 4580403 SGTC_3254 9136651 49.47 µM 0.53586841955868 0.331521683995531 no 1100 0.296024745876604 344 16454030 SGTC_1180 1193-0155 285 µM 0.535806652656454 0.331537713167797 no 1101 0.29604609195823 333 2921347 SGTC_2792 7535235 81.82 µM 0.535551547506749 0.331603918953017 no 1102 0.296134261469644 309 1281891 SGTC_2830 7992007 71.43 µM 0.534760736776094 0.331809186358867 no 1103 0.296407658226113 311 1952075 SGTC_1617 st002906 78 µM 0.531533378511207 0.332647421193575 no 1104 0.297524608712257 337 5150859 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.530391595789437 0.332944174719975 no 1105 0.297920225864907 350 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1079 idarubicin 2.36 µM 0.527090809700104 0.333802649236064 no 1106 0.29906526424823 352 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2485 5633444 17.78 µM 0.526970492990725 0.333833957900464 no 1107 0.299107039676387 311 5724239 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.526246352518508 0.334022417260427 no 1108 0.299358526005714 333 4213774 SGTC_2274 7947094 46.08 µM 0.525365374295393 0.334251750478164 no 1109 0.299664609660934 320 2971028 SGTC_1512 0259-0544 12.2 µM 0.521285068290089 0.335314727622949 no 1110 0.301084100589546 326 18476 SGTC_996 3970-0799 1.8 µM 0.520265873787981 0.335580448488869 no 1111 0.301439138928293 338 6615648 YGL040C HEM2 SGTC_2279 7948423 32.93 µM 0.514981207203023 0.33695956484715 no 1112 0.30328307615082 299 1247112 SGTC_389 tpck 16.7 µM 0.514924280876061 0.336974432642048 no 1113 0.303302966431906 314 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2003 4023581 200 µM 0.514621853754812 0.337053423642375 no 1114 0.303408645425342 338 16641307 SGTC_1640 st009078 66.4 µM 0.513919480345543 0.337236904411873 no 1115 0.303654143591363 342 690618 SGTC_2490 carminic acid 95.39 µM 0.512475989150655 0.33761410864796 no 1116 0.304158960266893 300 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2674 ligustilide 100 µM 0.512186952560526 0.337689657533655 no 1117 0.304260086845505 335 5319022 A signalling regulator. SGTC_653 0203-0016 55.2 µM 0.511642182288372 0.337832068313417 no 1118 0.304450728856676 351 295302 SGTC_2891 9063876 19.48 µM 0.510778195315677 0.338057974532686 no 1119 0.304753189512629 330 6472478 SGTC_3119 9125183 49.47 µM 0.509565893011427 0.338375052906382 no 1120 0.305177811879609 309 22695334 SGTC_2116 5511452 16.8835 µM 0.509499837953027 0.338392332940695 no 1121 0.305200955940731 346 870744 SGTC_1626 st003712 1.76 µM 0.50762152919357 0.338883841704794 no 1122 0.305859394641912 341 24207035 SGTC_2470 5664817 21.68 µM 0.507335537863495 0.33895870293291 no 1123 0.305959703672752 333 2859561 SGTC_232 clozapine 119 µM 0.504964930075929 0.339579478982301 no 1124 0.306791734019534 344 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_481 bay k-8644 50 µM 0.504216094856587 0.339775662303974 no 1125 0.307054765734776 355 2303 A calcium channel antagonist. SGTC_3090 9117696 49.47 µM 0.504091703651039 0.33980825509424 no 1126 0.307098468324951 337 7923821 SGTC_1114 scopoletin 1.73284 µM 0.502569464188428 0.340207206850661 no 1127 0.307633501319244 349 5280460 A coumarin with genotoxic properties. SGTC_1697 st025554 27.742 µM 0.501491914788011 0.340489721489876 no 1128 0.308012483312288 329 1269519 SGTC_201 4262-0159 12.803 µM 0.498964451664177 0.341152729245168 no 1129 0.30890221372555 347 1341029 SGTC_2200 6600604 21.907 µM 0.494822861654745 0.342240217271388 no 1130 0.310362582588838 368 2904777 SGTC_1657 st012939 43.4 µM 0.493280550560539 0.342645528487328 no 1131 0.310907184521339 326 24207257 SGTC_824 1304-0008 100 µM 0.491003036331664 0.343244378508999 no 1132 0.311712150011621 351 768245 SGTC_282 k297-0036 65.7 µM 0.490860180391866 0.343281954218502 no 1133 0.311762671120805 343 5061378 SGTC_1776 st049249 45.9 µM 0.482813131617552 0.345401078923178 no 1134 0.314614212992683 326 1822314 SGTC_1301 naphtanilide LB 4.81 µM 0.482467867003192 0.345492110638619 no 1135 0.314736809882959 336 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1650 st011916 45.8 µM 0.482112713548479 0.345585758948695 no 1136 0.314862939421637 370 242528 SGTC_2508 celastrol 40.54 µM 0.480786482751226 0.345935548391051 no 1137 0.315334129117182 317 122724 Celastrol is a natural product and antioxidant. SGTC_3056 9094900 49.47 µM 0.479629943098058 0.346240689666928 no 1138 0.31574527546492 335 25236784 SGTC_3278 9139605 49.47 µM 0.478998252661489 0.346407396964067 no 1139 0.315969935860806 351 7958859 SGTC_351 caspofungin 25 nM 0.47849584182938 0.346540007763169 no 1140 0.316148666572065 340 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2159 5658611 73.75 µM 0.474896459975275 0.347490609952831 no 1141 0.317430387388679 364 793844 SGTC_1046 2001-0062 216 µM 0.474203193664001 0.347673813067543 no 1142 0.317677508092113 336 739778 SGTC_637 1181-0519 7.26 µM 0.47259648265044 0.348098540532258 no 1143 0.31825054618816 352 6252091 YGR060W ERG25 SGTC_1055 3448-0672 86 µM 0.472562766998947 0.348107455170137 no 1144 0.31826257563902 335 748378 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.472238377472925 0.348193230162051 no 1145 0.318378324788791 380 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2049 5262831 67.185 µM 0.470575328510129 0.348633095006437 no 1146 0.31897201466426 362 763417 SGTC_1250 0485-0349 40.2 µM 0.47033387826583 0.348696973848315 no 1147 0.319058248370258 348 6842794 YDL195W SEC31 SGTC_2358 9037157 4 µM 0.469804046297082 0.348837162905935 no 1148 0.319247511630882 338 2388925 SGTC_1273 0849-0096 14.1 µM 0.469707738568922 0.348862647333528 no 1149 0.319281919136726 362 5286025 SGTC_161 4065-0411 162.148 µM 0.468971959280062 0.349057367745618 no 1150 0.319544839634541 358 1906281 YLR208W SEC13 SGTC_1840 st055363 71 µM 0.465701551719454 0.349923345587709 no 1151 0.32071457075447 346 676033 SGTC_749 1000-0129 128 µM 0.465693090337863 0.349925587109164 no 1152 0.32071759946493 361 708470 SGTC_1394 3474-0001 65.7 µM 0.464318038937718 0.350289924149651 no 1153 0.321209950874583 332 5017666 YIL048W NEO1 SGTC_1856 st057054 55.7 µM 0.461423588010385 0.351057295093849 no 1154 0.322247365756421 373 1266018 SGTC_192 3455-0609 60.9 µM 0.46078007128952 0.351227985632572 no 1155 0.32247820049002 322 3769639 SGTC_210 3551-0445 56.827 µM 0.459304450415413 0.35161950213643 no 1156 0.323007776161584 350 2865180 YOR207C RET1 SGTC_3314 9135860 59.4275 µM 0.457224765694083 0.352171558055004 no 1157 0.3237547496426 359 25252478 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.457188788441543 0.352181111024913 no 1158 0.32376767807972 374 5024745 SGTC_2945 9067681 61.76 µM 0.456597237492087 0.352338197769914 no 1159 0.323980282585278 379 16456930 SGTC_3199 9111318 49.47 µM 0.455761933016435 0.352560056323221 no 1160 0.324280590351637 356 8548020 SGTC_1220 1838-0075 193 µM 0.455368319845528 0.352664618168606 no 1161 0.324422141382861 346 5529645 SGTC_2791 5663188 71.43 µM 0.455025931032338 0.352755581511332 no 1162 0.324545291764482 394 54690634 SGTC_2582 agaric acid 100 µM 0.454734136099812 0.352833110088488 no 1163 0.324650259687792 326 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1376 2910-0861 41.3 µM 0.45328312338933 0.353218728221118 no 1164 0.325172441847447 359 1112859 SGTC_3136 9095672 49.47 µM 0.452606492975431 0.353398599685531 no 1165 0.325416061244279 329 17217380 SGTC_2740 felodipine 17.08 µM 0.450647539806421 0.353919540843203 no 1166 0.326121798755094 371 3333 L-type calcium channel blocker SGTC_2780 5215298 71.43 µM 0.448592980464526 0.354466200351348 no 1167 0.326862649224363 371 2834131 SGTC_1826 st055655 41.6 µM 0.447644360374443 0.354718702322778 no 1168 0.327204941389818 352 676168 SGTC_1009 4106-0057 9.87 µM 0.447559195344385 0.354741374520459 no 1169 0.327235678744968 363 2928005 SGTC_141 0443-0274 32.331 µM 0.447208042541097 0.354834862053152 no 1170 0.327362427507222 328 1627241 SGTC_993 3909-8757 62.7 µM 0.446823212499541 0.354937325528709 no 1171 0.327501354944458 340 4288324 YLR208W SEC13 SGTC_788 1182-0090 188 µM 0.445958018476904 0.355167727310338 no 1172 0.327813785723142 336 5715185 SGTC_2018 5133068 143 µM 0.444843240757799 0.355464671479029 no 1173 0.328216521567436 356 785362 SGTC_1198 1612-1005 86.7 µM 0.444190596871463 0.355638557456375 no 1174 0.328452395018604 355 6998509 SGTC_2523 spermine 47.74 µM 0.444137068562507 0.355652820506967 no 1175 0.328471743837233 347 1103 A DNA binding polyamine. SGTC_1150 3909-7983 10.9 µM 0.444107124544271 0.35566079942082 no 1176 0.328482567869025 358 23965914 SGTC_387 norethindrone acetate 66.7 µM 0.443116303617314 0.355924850232492 no 1177 0.328840806587718 375 541197 SGTC_2976 9009005 19.48 µM 0.441798915831221 0.356276037178167 no 1178 0.329317361589611 342 2993148 SGTC_1997 st073024 93.8 µM 0.4414945383424 0.356357194951518 no 1179 0.329427507309848 357 686268 SGTC_2714 st079313 56.9 µM 0.440067687026409 0.35673773051704 no 1180 0.329944042192269 352 2939799 SGTC_2663 amphotericin b 100 µM 0.439114598213707 0.356991994986238 no 1181 0.330289250954519 360 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2184 6075246 200 µM 0.439043838093573 0.357010874864146 no 1182 0.330314886035232 353 2267320 SGTC_2438 5259590 200 µM 0.438446969148937 0.357170142520775 no 1183 0.330531152278481 383 1201127 SGTC_2821 7996764 71.43 µM 0.437843818203138 0.357331111741978 no 1184 0.330749752207635 312 2987135 SGTC_2267 7931562 200 µM 0.437703239516321 0.357368633100673 no 1185 0.330800710424276 343 934880 SGTC_3015 9080845 49.47 µM 0.436228376482731 0.357762366624853 no 1186 0.331335520797057 371 5296973 SGTC_2465 5809242 33.21 µM 0.436183677827173 0.357774301867608 no 1187 0.331351734666944 373 2731748 SGTC_3024 9090631 49.47 µM 0.436153197334831 0.357782440717317 no 1188 0.331362791259898 346 25236383 SGTC_2910 7948405 25.97 µM 0.435797992254932 0.357877291745565 no 1189 0.331491650341352 375 2971328 SGTC_3140 9094243 49.47 µM 0.434674939925685 0.358177240065241 no 1190 0.331899195434614 394 19291112 SGTC_2684 capsaicin 100 µM 0.43432850863713 0.358269783692307 no 1191 0.332024952260144 377 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2342 7990637 118.86 µM 0.431553837295643 0.359011293151563 no 1192 0.33303285782661 382 2033102 YER133W GLC7 SGTC_2224 6650123 117.647 µM 0.428152441084433 0.359921014989571 no 1193 0.334270069516999 375 2908370 SGTC_2957 9076800 11.52 µM 0.426831534096825 0.360274513065902 no 1194 0.334751018210984 355 16459615 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.426593619317671 0.36033819597708 no 1195 0.334837672992109 348 2333 A French combination drug. SGTC_1303 1160-0052 261 µM 0.426377117434186 0.360396150642427 no 1196 0.334916536280571 369 3562476 SGTC_1427 4048-4900 550 nM 0.424776224934755 0.360824787672901 no 1197 0.335499905440086 373 24132586 SGTC_2429 5902844 64.44 µM 0.424574063773773 0.360878928526516 no 1198 0.335573601709711 383 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2259 7964009 200 µM 0.42424837617829 0.36096615690247 no 1199 0.335692341878125 331 313134 SGTC_1514 1189-1591 158 µM 0.423931022449478 0.361051160189123 no 1200 0.335808059443662 391 767698 YMR146C TIF34 SGTC_3264 9137442 49.47 µM 0.422164024627756 0.361524576432829 no 1201 0.336452649147277 346 17015726 SGTC_3308 9128332 17.569 µM 0.419794161186898 0.362159846036543 no 1202 0.337317915332783 372 17332805 YDL196W YDL196W SGTC_1204 4049-0315 18.3 µM 0.41907396242575 0.36235297907734 no 1203 0.337581039545912 350 588402 SGTC_613 3914-0030 117 µM 0.417475655121352 0.362781716348884 no 1204 0.338165263787598 376 1145395 SGTC_466 geldanamycin 89.2 µM 0.417428513785787 0.362794364371749 no 1205 0.33818250113817 367 5288382 HSP90 inhibitor. SGTC_670 4204-0025 119 µM 0.417358555740558 0.362813134394943 no 1206 0.338208082102491 402 719039 SGTC_2074 5212007 75.395 µM 0.417116184204693 0.362878166195853 no 1207 0.338296713819588 386 758611 SGTC_1647 st011722 22.4 µM 0.416988821184697 0.362912341127904 no 1208 0.338343292200536 354 2854783 SGTC_2150 5556613 200 µM 0.416297649862975 0.363097820060652 no 1209 0.338596106034455 374 743190 SGTC_2552 juarezic acid 87.02 µM 0.414920778562292 0.363467405333631 no 1210 0.339099949140855 348 1549512 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.410559817129406 0.364638829415434 no 1211 0.34069766668812 391 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1952 st077036 64.1 µM 0.410165352122963 0.364744851583639 no 1212 0.340842327701805 362 2937007 SGTC_1960 st011366 51.8 µM 0.410094978179125 0.36476376739877 no 1213 0.340868138196212 363 3972846 SGTC_2384 9036245 200 µM 0.408994926298814 0.365059493153612 no 1214 0.341271692278827 360 6462766 SGTC_2814 7977482 42.97 µM 0.407881193135912 0.365358978615577 no 1215 0.341680450346976 375 6456762 SGTC_813 k007-0158 173 µM 0.405380250748343 0.366031786892736 no 1216 0.34259901277721 378 6523916 SGTC_2128 5255449 168.493 µM 0.396613051278509 0.368393598225602 no 1217 0.345826413381478 336 736008 SGTC_378 3970-0959 8.33 µM 0.39642688092631 0.368443805309643 no 1218 0.345895069451656 386 6615653 SGTC_2724 maprotiline 69.64 µM 0.39635162032873 0.368464102493432 no 1219 0.345922825561012 391 4011 A tricyclic antidepressant. SGTC_1845 st056753 3.01 µM 0.395405660978338 0.368719251479153 no 1220 0.346271765943723 348 5375839 SGTC_2417 cerulenin 830 nM 0.392600487356849 0.369476217156142 no 1221 0.347307289771827 364 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_273 hydroxyurea 18.1 mM 0.391430683513591 0.369792034121885 no 1222 0.347739457886694 389 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1951 sophoraflavanone G 9.2 µM 0.390283142455851 0.370101926067039 no 1223 0.348163593640711 378 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_315 k915-0449 187 µM 0.389719670736222 0.370254121749775 no 1224 0.34837192461805 387 20970215 YNL149C PGA2 SGTC_2034 5197015 53.07 µM 0.388059106273965 0.370702764093698 no 1225 0.348986146818145 398 780676 SGTC_1395 3486-0190 4.35 µM 0.387071762314726 0.370969602767834 no 1226 0.349351540889115 390 6748079 SGTC_2326 6164455 177.58 µM 0.386976269196161 0.370995413943855 no 1227 0.349386888183802 389 2888790 SGTC_3089 9117425 49.47 µM 0.385299843267365 0.371448635532204 no 1228 0.350007638820949 396 9401657 SGTC_2880 9042983 58.44 µM 0.385006702519801 0.371527904435933 no 1229 0.350116224855369 384 6464714 SGTC_1581 himbacine 57.9 µM 0.38395623942894 0.37181200744324 no 1230 0.350505440992472 395 5281825 An alkaloid muscarinic receptor antagonist. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.383904524782191 0.371825995733119 no 1231 0.350524606290352 367 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1323 1348-1351 11.2 µM 0.38235404920801 0.372245462232809 no 1232 0.351099384555711 406 6989654 SGTC_519 k048-0011 62.8 µM 0.38203329317159 0.372332258689406 no 1233 0.351218334918301 368 6836379 SGTC_1816 st051957 91.6 µM 0.379965793699328 0.372891878683356 no 1234 0.35198540345954 375 674121 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.37900611196134 0.373151731601789 no 1235 0.352341662584906 378 6708630 An antioxidant. SGTC_2677 mitomycin C 100 µM 0.378931280990096 0.373171996002531 no 1236 0.352369447261956 386 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3313 9133968 57.047 µM 0.377457304147358 0.373571223803967 no 1237 0.352916894062979 399 1494643 SGTC_2565 isoliquiritigenin 100 µM 0.376587355238238 0.373806913876219 no 1238 0.353240143089456 337 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3296 9122258 64.045 µM 0.375825114027776 0.374013462139992 no 1239 0.353523457971156 383 4730474 SGTC_2935 9038016 29.96 µM 0.373913855385313 0.374531524295169 no 1240 0.354234203919388 386 6463195 SGTC_358 0075-0058 9.45 µM 0.372581258217703 0.374892869687368 no 1241 0.35473006192585 419 1069125 SGTC_1907 st060210 83.7 µM 0.371310376464172 0.375237582754395 no 1242 0.355203185114617 404 688793 SGTC_2576 guaiol 23.12 µM 0.370851547160433 0.375362059789446 no 1243 0.355374052746251 369 227829 SGTC_1905 st060207 84.5 µM 0.369828233235367 0.375639724107949 no 1244 0.355755238652111 386 1948547 SGTC_1136 pergolide 1.05886 µM 0.369624825780618 0.375694924032125 no 1245 0.355831025422601 390 47811 A dopamine receptor agonist. SGTC_1963 st076565 50.3 µM 0.368839786106656 0.37590798889634 no 1246 0.356123573626669 399 4914280 SGTC_1703 st026983 48.3 µM 0.368696781020657 0.375946805481062 no 1247 0.35617687417606 384 1104023 SGTC_852 0418-0143 439 µM 0.368440934189279 0.376016254395805 no 1248 0.356272239870196 377 5369229 SGTC_121 0557-0495 61.343 µM 0.368279360832928 0.37606011510539 no 1249 0.35633247020496 427 3104427 SGTC_3347 9188721 44.724 µM 0.365258641462865 0.376880413893587 no 1250 0.357459174020515 417 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_691 1548-0686 185 µM 0.365140919782445 0.376912393372158 no 1251 0.35750310849134 394 46495133 SGTC_2712 st079126 47.7 µM 0.364123559627292 0.377188797739042 no 1252 0.357882872322478 387 3152970 SGTC_1122 capsaicin 818.572 nM 0.364083729943384 0.377199620260272 no 1253 0.357897742953505 412 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2772 vinpocetine 57.06 µM 0.36300258264236 0.377493426409631 no 1254 0.358301477534091 422 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2162 5663267 200 µM 0.362782090790609 0.377553354672436 no 1255 0.35838383563156 405 6456493 SGTC_2919 7978188 46.38 µM 0.361835437182918 0.37781068249815 no 1256 0.358737504424434 367 2980291 SGTC_945 3381-0768 11.3 µM 0.361218539568287 0.377978402302969 no 1257 0.358968041947913 414 1126236 YIL048W NEO1 SGTC_3163 9099914 49.47 µM 0.360297265533011 0.378228917641636 no 1258 0.35931242199546 422 16268368 SGTC_34 0469-0683 81.75 µM 0.359968934139966 0.37831821078667 no 1259 0.359435182701493 383 3690923 SGTC_1121 fusaric acid 630.51 nM 0.359680171576408 0.378396748147398 no 1260 0.359543160904246 353 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3341 9147222 25.867 µM 0.358370042713169 0.37875313877764 no 1261 0.360033203673241 398 1939759 SGTC_1 0258-0098 57.368 µM 0.357727541833998 0.378927954172494 no 1262 0.360273609915414 356 6790032 YDR047W HEM12 SGTC_994 3910-0338 138 µM 0.357673776110509 0.378942584188398 no 1263 0.360293730084323 398 3479481 SGTC_2825 7998094 58.44 µM 0.355955898577471 0.379410121440614 no 1264 0.360936796340249 404 2987815 SGTC_1071 trifluoperazine 6.31 µM 0.351734652182109 0.380559723161689 no 1265 0.36251863521747 418 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2051 5263410 176 µM 0.350733325667749 0.380832576723523 no 1266 0.362894210781597 378 227584 SGTC_1588 farnesol 29.9 µM 0.349467065765353 0.381177707400572 no 1267 0.363369345893852 392 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.347118328670349 0.381818127210156 no 1268 0.364251212160731 388 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.346937331529544 0.381867492354963 no 1269 0.36431919997877 359 688803 SGTC_594 1487-1584 10.8 µM 0.346618127357609 0.38195455675453 no 1270 0.364439112801522 392 5013332 SGTC_63 0099-0242 26.702 µM 0.344562832288876 0.382515290704347 no 1271 0.365211525989408 380 3898502 YLR359W ADE13 SGTC_2717 st081029 62.2815 µM 0.33981644865 0.383811158182206 no 1272 0.36699738002462 435 5292846 SGTC_424 splitomicin 100 mM 0.337690135797458 0.384392111164585 no 1273 0.367798354521199 401 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_587 k089-0003 57 µM 0.336367458973884 0.384753625180269 no 1274 0.36829689264119 418 9659696 SGTC_2335 9018011 154.17 µM 0.335240748398711 0.385061656770326 no 1275 0.368721742950262 425 6458208 SGTC_1357 1503-1303 39.5 µM 0.333153798249937 0.385632399916854 no 1276 0.369509095738052 378 292895 SGTC_946 3434-1334 87.4 µM 0.33057522933145 0.386337933932866 no 1277 0.370482679666093 393 4047976 SGTC_3086 9117350 49.47 µM 0.328152783583222 0.387001092958912 no 1278 0.371398073024687 391 2679265 SGTC_3291 9121177 71.43 µM 0.32674393974024 0.3873869242926 no 1279 0.371930781783283 377 17015612 SGTC_3074 9116018 49.47 µM 0.325464535682691 0.387737403165152 no 1280 0.37241475960723 410 17027303 SGTC_2734 clemastine 41.6 µM 0.325458516868152 0.387739052170576 no 1281 0.372417036904163 438 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2176 5809774 33.9695 µM 0.325375898878767 0.387761687648609 no 1282 0.372448296948175 423 2870539 SGTC_2737 bleomycin 30.5 nM 0.325012606146103 0.387861226243107 no 1283 0.372585765440799 420 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3250 9135583 49.47 µM 0.321531135816896 0.388815487268241 no 1284 0.373903960440314 383 7699353 SGTC_313 3474-0040 5.03 µM 0.320703598424321 0.38904241184543 no 1285 0.374217510037751 395 1043375 YIL048W NEO1 SGTC_1498 4478-3555 97.6 µM 0.317433438714456 0.389939513935108 no 1286 0.375457368874072 415 3437919 SGTC_2708 st078559 56 µM 0.317095260230878 0.39003231990004 no 1287 0.375585660620952 403 17250902 SGTC_831 k061-1017 217 µM 0.316047498490206 0.390319895825958 no 1288 0.375983227909395 429 1240153 SGTC_2614 arthonioic acid 13.39 µM 0.315143752192079 0.390567992499979 no 1289 0.376326255133342 385 6710684 SGTC_1227 3909-8010 46.6 µM 0.314735645632833 0.390680040631838 no 1290 0.376481188676087 406 15982272 SGTC_1375 2910-0797 186 µM 0.314308730073536 0.390797262604042 no 1291 0.376643284164608 432 742508 SGTC_521 r062-0005 13.8 µM 0.314036179363766 0.390872104448356 no 1292 0.376746780270322 395 2832033 SGTC_2445 5742597 35.57 µM 0.31389276755358 0.390911486649172 no 1293 0.376801241817912 386 1774255 SGTC_1378 2093-0007 380 nM 0.310624561687922 0.391809268518979 no 1294 0.378043026367257 438 3618014 SGTC_97 0535-0701 19.132 µM 0.310116520168754 0.39194888030141 no 1295 0.37823617493921 397 2832013 YGL099W LSG1 SGTC_92 0063-0024 660.874 µM 0.309348114739551 0.392160067528735 no 1296 0.37852836716313 431 3594437 SGTC_415 dibenzyl ketone 100 µM 0.308995074010268 0.392257107291053 no 1297 0.378662636982847 434 7593 SGTC_991 3996-0057 64.7 µM 0.307792738506363 0.392587641636545 no 1298 0.379120023685291 372 715343 SGTC_2858 9025781 8.96 µM 0.307223481910258 0.392744163149488 no 1299 0.379336636636911 413 4894980 YPL153C RAD53 SGTC_2495 cafestol 54.53 µM 0.307129844539069 0.392769911132412 no 1300 0.379372271066148 412 16667697 An anti-infammatory. SGTC_3025 9087895 49.47 µM 0.30686257176609 0.392843407177561 no 1301 0.379473989433166 404 17173641 SGTC_2788 5282734 71.43 µM 0.29986706709695 0.394768418354691 no 1302 0.382139277811343 414 743706 SGTC_1691 st019933 84.6 µM 0.296448486363575 0.395710076195574 no 1303 0.383443800825969 440 6176082 SGTC_541 4513-1321 94 µM 0.296388790959027 0.395726524892015 no 1304 0.383466592254044 394 747515 SGTC_3290 9121031 71.43 µM 0.293107488662165 0.396630952166499 no 1305 0.384719996453819 403 17014854 SGTC_1161 k007-0610 110 µM 0.29217023510635 0.396889390291674 no 1306 0.385078234081642 415 5843850 SGTC_2925 9010536 32.5 µM 0.292111119799652 0.396905692255219 no 1307 0.385100832462639 384 2994177 SGTC_3005 9076496 71.4286 µM 0.291601256625377 0.397046302415738 no 1308 0.38529575726272 426 21368410 SGTC_2861 9024595 19.48 µM 0.2882242191059 0.397977959531053 no 1309 0.3865875554423 411 16482810 SGTC_46 0329-0187a 2.197 µM 0.288127502897833 0.398004650197033 no 1310 0.386624570315242 430 46494817 SGTC_68 0986-0284 82.829 µM 0.287805298170122 0.398093572125968 no 1311 0.386747890769029 369 423278 YIL048W NEO1 SGTC_2081 5214970 32.255 µM 0.287531480488465 0.398169144378432 no 1312 0.386852700581958 411 2063512 SGTC_770 0389-1121 67.2 µM 0.286775298032431 0.398377866627142 no 1313 0.387142189090328 396 6753108 SGTC_2177 5811945 192 µM 0.286113960021457 0.398560433653087 no 1314 0.387395419873531 439 5343475 SGTC_2556 citropten 84.59 µM 0.285744994574627 0.398662298820219 no 1315 0.387536720062666 364 2775 A potential DNA crosslinker. SGTC_2282 7944268 200 µM 0.283665143228229 0.399236639826541 no 1316 0.388333504771287 415 2970414 SGTC_1732 st034308 51.822 µM 0.28340918522073 0.399307336508992 no 1317 0.388431594062666 385 830119 SGTC_1508 1080-0625 72.9 µM 0.280573404573266 0.400090811568479 no 1318 0.389518808510834 413 767111 SGTC_2234 tolnaftate 200 µM 0.279746342505716 0.400319389821303 no 1319 0.389836060509586 437 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3177 9107506 49.47 µM 0.278381068060694 0.400696790528427 no 1320 0.39035992542989 444 8897194 SGTC_703 3875-0075 71.8 µM 0.277187971333344 0.401026672341035 no 1321 0.390817887695062 437 2850814 SGTC_327 1273-0057 3.96 µM 0.275334563514133 0.401539264850987 no 1322 0.391529606202588 432 3108138 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.274830055063451 0.40167882491179 no 1323 0.391723403142386 439 6710655 SGTC_1210 3013-0140 750 nM 0.272615378859665 0.40229160964676 no 1324 0.392574444480441 428 905973 SGTC_841 0251-0215 91.2 µM 0.271808231204817 0.402515001313137 no 1325 0.392884737919507 440 3888614 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.271611541000661 0.402569443456899 no 1326 0.392960362264678 421 688662 SGTC_1120 ficusin 1.78878 µM 0.270614442263336 0.402845460793521 no 1327 0.393343793424929 426 6199 A DNA cross-linker. SGTC_1808 st050063 61.5 µM 0.263309216187718 0.404869165520473 no 1328 0.396156128386083 455 4011993 SGTC_1554 st069299 38.7 µM 0.257858754754383 0.406380722821282 no 1329 0.398257958773289 404 24207999 SGTC_505 gw-5074 63.9 µM 0.256850396408201 0.406660521013525 no 1330 0.398647132026733 442 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_971 1315-0384 26.7 µM 0.254804565837944 0.407228342175828 no 1331 0.399437024310588 447 6769120 SGTC_3103 9120822 49.47 µM 0.254275756498571 0.407375145204448 no 1332 0.399641263960514 464 17141819 SGTC_1039 k821-0043 94 µM 0.252526729004913 0.407860786184494 no 1333 0.400316978323742 431 15992768 SGTC_3237 9133362 49.47 µM 0.251603565171433 0.408117172167591 no 1334 0.400673751326942 461 43845137 SGTC_2653 dihydrofissinolide 100 µM 0.249972104447677 0.408570366281514 no 1335 0.40130446067537 426 6857746 SGTC_722 3534-0461 190 µM 0.249624748370374 0.408666872144278 no 1336 0.401438778960863 406 658262 SGTC_3091 9116372 49.47 µM 0.249518633218754 0.408696355198222 no 1337 0.401479814696684 403 17169793 SGTC_1479 0549-0158 134 µM 0.24852004994174 0.408973827053733 no 1338 0.401866029485756 413 5440202 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.247095307563131 0.409369792776781 no 1339 0.402417232591393 425 88881 An O-methylated flavonoid and antioxidant. SGTC_995 3931-2021 34.6 µM 0.246196736596384 0.409619572035284 no 1340 0.402764970824072 434 730143 SGTC_515 4092-1064 102 µM 0.245923589353225 0.409695507110385 no 1341 0.402870691413384 459 717353 SGTC_1673 st016611 27.3 µM 0.244723184491643 0.410029260402338 no 1342 0.403335387582282 446 5226799 SGTC_316 k060-0003 58.6 µM 0.243933700180526 0.410248799385873 no 1343 0.403641084213849 438 6152314 SGTC_1183 1254-0324 198 µM 0.243544133340025 0.410357140101004 no 1344 0.40379195029863 418 5799357 SGTC_2990 9074105 71.4286 µM 0.240940113945728 0.411081507770387 no 1345 0.404800765677036 463 6502001 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.23662313030241 0.412283042764057 no 1346 0.406474587168887 441 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1899 st063254 59.6 µM 0.236315669495532 0.412368649055159 no 1347 0.406593864368929 440 3093813 SGTC_2246 7293507 91.5585 µM 0.234211474350191 0.41295463166292 no 1348 0.407410403745768 462 887656 SGTC_1602 st001878 87.6 µM 0.231036502183413 0.413839174307767 no 1349 0.40864322220149 468 595405 YLR310C CDC25 SGTC_1366 1683-0113 21.9 µM 0.229256631380908 0.414335235332152 no 1350 0.409334729481206 409 708623 SGTC_2489 cantharidin 73.42 µM 0.225948210152454 0.415257675418266 no 1351 0.410620850477526 463 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_977 1348-1378 135 µM 0.225572257344489 0.415362526660809 no 1352 0.410767060082758 466 X977 SGTC_1189 1431-2119 7.28 µM 0.225402550382712 0.415409859006575 no 1353 0.410833063886738 463 3107275 SGTC_2435 5706476 10.6 µM 0.225027073240109 0.415514586319646 no 1354 0.410979106463806 443 5725375 SGTC_812 4251-0442 148 µM 0.224975502875797 0.415528970688622 no 1355 0.410999165823236 460 5723007 SGTC_3016 9080866 49.47 µM 0.224665134343241 0.415615543254186 no 1356 0.411119894994295 461 17066299 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.224162430780026 0.415755773429512 no 1357 0.41131545775269 452 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_295 k015-0027 31 µM 0.223371386696751 0.415976458492642 no 1358 0.411623235931423 431 3887424 SGTC_2751 anetholtrithion 17.25 µM 0.223360342248476 0.415979539854742 no 1359 0.411627533473269 445 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1185 1319-0113 81.3 µM 0.221903295191645 0.4163860960606 no 1360 0.412194582644724 449 4672763 SGTC_1534 6-azauridine 81.6 µM 0.221595097434282 0.41647210319068 no 1361 0.412314549650883 453 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1447 4239-0816 81.9 µM 0.219936512964881 0.416935024222253 no 1362 0.412960299614531 428 1341554 SGTC_3215 9129942 49.47 µM 0.219319199202166 0.417107349705325 no 1363 0.4132007035753 476 17682944 SGTC_1575 cyproterone acetate 48 µM 0.219107300967877 0.417166505576044 no 1364 0.413283231801698 455 9880 An androgen receptor antagonist and liver toxin. SGTC_2239 6685329 187.64 µM 0.218586371446393 0.417311942031119 no 1365 0.413486135047613 396 805680 SGTC_1439 4092-1168 46 µM 0.217599156798653 0.417587589988686 no 1366 0.413870720763367 468 2886240 SGTC_585 0kpi-0023 191 µM 0.216244569659273 0.417965880792885 no 1367 0.414398556874143 456 64601 SGTC_1871 st057448 67.3 µM 0.211037258032053 0.419420812303804 no 1368 0.416429099150579 474 691747 SGTC_3107 9121808 49.47 µM 0.210900576233647 0.419459016358972 no 1369 0.416482427235234 423 662681 SGTC_1119 parthenolide 318.541 nM 0.210563827925534 0.419553144427115 no 1370 0.416613820286572 452 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1065 prochlorperazine maleate 2.48 µM 0.2101532506315 0.419667915440453 no 1371 0.416774032665944 480 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.209428035704497 0.419870655595855 no 1372 0.417057054331324 482 1273210 SGTC_1006 4099-6547 255 µM 0.208401487953647 0.420157672316499 no 1373 0.417457747307837 435 3146833 SGTC_3011 9081274 71.4286 µM 0.206294895270453 0.420746796079708 no 1374 0.418280282881762 434 6625322 SGTC_1938 st074717 56.4 µM 0.20608510616686 0.420805474850395 no 1375 0.4183622163098 452 17250979 SGTC_3067 9117431 49.47 µM 0.206076083022637 0.42080799869593 no 1376 0.418365740390887 455 17150885 SGTC_2305 7443522 69.23 µM 0.20510038963521 0.42108092711628 no 1377 0.418746846009981 445 5415886 SGTC_1023 4482-3888 16 µM 0.204058055531002 0.421372538690052 no 1378 0.419154065734161 461 3303168 SGTC_1986 st071812 45 µM 0.203632061799961 0.42149173046659 no 1379 0.419320518184631 476 11838594 SGTC_170 4197-0004 226 µM 0.20052118359899 0.422362362328108 no 1380 0.420536496153133 439 218692 SGTC_2899 9053889 58.44 µM 0.198934303778409 0.422806623903429 no 1381 0.421157067617658 467 6470052 SGTC_147 4466-0538 29.23 µM 0.196750242865755 0.4234182322787 no 1382 0.422011495174162 416 6742687 YHR072W ERG7 SGTC_2070 5230947 200 µM 0.192966089037801 0.424478355040279 no 1383 0.423492762974512 471 2835538 SGTC_3230 9131665 49.47 µM 0.192355206030656 0.424649544073406 no 1384 0.423731988768926 476 15943720 SGTC_661 1304-0007 33.6 µM 0.191354245347089 0.42493007610697 no 1385 0.424124032271696 457 3117130 SGTC_978 1416-0512 87.4 µM 0.189873179103437 0.425345233575246 no 1386 0.424704255048275 452 6814003 SGTC_876 0720-0963 56.8 µM 0.189043905293304 0.425577723385343 no 1387 0.425029202850155 473 765861 SGTC_1677 st019204 53.9 µM 0.188516483623403 0.425725601361259 no 1388 0.42523589755235 423 3945625 SGTC_2156 5649887 115 µM 0.184143751887989 0.426952024105246 no 1389 0.426950342129171 462 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3317 9138495 8.753 µM 0.183663098287436 0.427086876623843 no 1390 0.427138879844483 498 17020139 SGTC_3092 9117248 49.47 µM 0.182583666985014 0.42738975367692 no 1391 0.427562350382083 491 17141857 SGTC_1197 1601-0112 267 µM 0.182244184737443 0.427485017675282 no 1392 0.427695549574837 482 7350313 SGTC_1052 3253-3998 198 µM 0.181886976434086 0.427585260445565 no 1393 0.427835712657138 441 5450317 SGTC_2483 5729050 27.16 µM 0.181854997736915 0.427594234802092 no 1394 0.427848261053864 482 2865180 SGTC_2728 chlorpromazine 9.18 µM 0.181250178744327 0.427763975510397 no 1395 0.42808560492162 494 2726 A thorazine and dopamine antagonist. SGTC_293 4049-0273 38.5 µM 0.181029580742023 0.427825889033574 no 1396 0.428172178761312 453 1380311 SGTC_2033 5192550 145 µM 0.180339461715206 0.428019590835119 no 1397 0.428443038762019 467 182073 SGTC_264 promethazine 12.5 mM 0.178463502408738 0.428546220435409 no 1398 0.429179490950564 481 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1078 idebenone 36.1 µM 0.176764956757551 0.429023155304225 no 1399 0.429846508000489 480 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_37 0566-0070 1.56 µM 0.175981988195641 0.429243040097919 no 1400 0.430154046470614 487 1626686 SGTC_1609 st001574 46.4 µM 0.175528307909744 0.429370459347159 no 1401 0.430332264780053 496 3960012 SGTC_2133 5320837 200 µM 0.175393407755076 0.42940834840957 no 1402 0.430385260074177 457 2841355 SGTC_1591 genipin 88.4 µM 0.175279271826787 0.429440405984558 no 1403 0.430430099156919 472 442424 A DNA cross-linking agent. SGTC_2403 6032726 181.2 µM 0.175237774865914 0.42945206143014 no 1404 0.430446401745182 458 2881040 SGTC_2775 cyproheptadine 69.59 µM 0.174073218431317 0.429779180889127 no 1405 0.430903960220486 484 2913 A selective serotonin reuptake inhibitor. SGTC_1115 galangin 695.678 nM 0.174003977952207 0.429798631796255 no 1406 0.430931167985189 491 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_94 0334-0113 514.748 µM 0.172356803668818 0.430261403084063 no 1407 0.431578514793777 487 6795178 SGTC_166 k072-0058 166.424 µM 0.170939292316165 0.430659727622304 no 1408 0.432135750267339 494 5846229 SGTC_2334 9017922 200 µM 0.170916714363399 0.43066607266025 no 1409 0.432144626943356 471 3163164 SGTC_1613 st002381 52.1 µM 0.170796645247305 0.430699815749969 no 1410 0.432191833510065 440 551167 SGTC_1088 bifonazole 369 nM 0.17069206802163 0.430729205557458 no 1411 0.432232950049046 476 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_409 arachidonic acid 100 µM 0.16971219733201 0.431004601636018 no 1412 0.43261824057345 445 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1429 4049-0205 9.46 µM 0.16826679156941 0.431410899182754 no 1413 0.43318669890968 445 22774478 SGTC_366 0181-0206 4.31 µM 0.167199695314123 0.431710902098109 no 1414 0.433606462074347 453 274874 SGTC_589 1227-0070 34.1 µM 0.166427005008232 0.431928160468516 no 1415 0.433910461686263 469 2841384 SGTC_2266 7929956 200 µM 0.162537983793455 0.433021953072157 no 1416 0.435441109599406 492 2967153 SGTC_575 k072-0246 11.9 µM 0.159910470382241 0.433761235946349 no 1417 0.436475800244946 477 6796779 SGTC_2946 9065502 71.43 µM 0.158433259970313 0.43417696902637 no 1418 0.437057703536505 452 16489101 SGTC_683 panaxydol 45 µM 0.157540179388242 0.434428345101341 no 1419 0.437409572325258 462 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2656 pseudo-anisatin 100 µM 0.155612072167929 0.434971141197923 no 1420 0.438169404328083 494 6708809 A neurotoxin. SGTC_1335 1486-0900 202 µM 0.152155919050072 0.435944415218311 no 1421 0.439531980284345 475 X1335 SGTC_509 pifithrin 175 µM 0.152079224489525 0.435966017301985 no 1422 0.439562225027097 487 4817 A p53 inhibitor. SGTC_1747 st037496 66.6 µM 0.151869181103591 0.436025179904379 no 1423 0.439645058106798 448 723305 SGTC_608 k048-0125 159 µM 0.150673163362875 0.436362087654332 no 1424 0.440116772023223 487 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1807 st050092 58.9 µM 0.150347946003407 0.436453706538596 no 1425 0.440245053707713 471 5008496 SGTC_2709 st078560 56 µM 0.149843341620801 0.43659586833718 no 1426 0.440444106848212 480 17250903 SGTC_2432 5630864 12.22 µM 0.149353715504362 0.436733818149237 no 1427 0.440637265845391 465 5714970 SGTC_363 0455-0021 3.06 µM 0.149062513144179 0.43681586666865 no 1428 0.440752152766966 477 4597466 SGTC_2940 9060638 45.86 µM 0.147550618719525 0.437241898239986 no 1429 0.441348714473726 452 4027022 SGTC_2402 5553605 200 µM 0.146272611404931 0.437602080344857 no 1430 0.441853093109404 463 6758546 SGTC_2194 5927483 104.545 µM 0.145516695230289 0.437815145329324 no 1431 0.442151467579439 425 760979 SGTC_1729 st035615 45.989 µM 0.145379063608534 0.437853940566683 no 1432 0.442205796931341 488 17385451 SGTC_2405 ticlatone 3.52 µM 0.145223094774733 0.437897905370879 no 1433 0.442267366114253 405 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1473 k844-0725 134 µM 0.145076498250698 0.437939228988715 no 1434 0.442325236820112 485 54682906 SGTC_1144 3486-0183 12.5 µM 0.14442180146646 0.438123787592405 no 1435 0.442583701098086 499 6744069 SGTC_854 0422-0053 192 µM 0.142966249304543 0.438534154980998 no 1436 0.443158418240899 484 3596728 SGTC_1307 1187-1599 12.2 µM 0.14267037576053 0.438617579431448 no 1437 0.443275257025462 488 1538471 SGTC_125 0133-0007 11.75 µM 0.140265307666367 0.439295812859076 no 1438 0.444225186886331 491 26541 SGTC_633 0437-0093 97.7 µM 0.139484450353598 0.439516054418665 no 1439 0.444533671320642 468 2831118 SGTC_1253 0550-0034 176 µM 0.139014195652785 0.439648699248372 no 1440 0.444719465729808 462 5969915 SGTC_1597 7-benzyloxygramine 47.5 µM 0.136968240989609 0.440225880730906 no 1441 0.445527949249531 486 260807 SGTC_449 xestospongin c 11.1929 µM 0.136238801734298 0.440431692630231 no 1442 0.445816250885618 490 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_727 3032-0951 202 µM 0.135442068076257 0.440656510089873 no 1443 0.446131182516758 486 3652836 SGTC_3021 9087658 49.47 µM 0.135332848795931 0.440687330414871 no 1444 0.446174357195875 500 25237042 SGTC_2950 9072895 21.46 µM 0.134927635144793 0.440801679814541 no 1445 0.446334544828269 459 17332245 SGTC_3128 9127691 49.47 µM 0.13163363925958 0.44173141239883 no 1446 0.447637038376393 494 41316314 SGTC_1216 1165-0504 9.65 µM 0.127952033115884 0.442770928059553 no 1447 0.449093466475168 470 6304004 SGTC_2095 5432005 200 µM 0.127038266683343 0.443028994849937 no 1448 0.4494550557329 513 783734 SGTC_3147 9097027 49.47 µM 0.126402127301756 0.443208668219836 no 1449 0.449706809158539 485 25236841 SGTC_474 dl-dihydrosphingosine 5 µM 0.12586184060234 0.443361277804718 no 1450 0.449920644596914 451 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2887 9044784 58.44 µM 0.124782102696974 0.443666286130294 no 1451 0.450348028308266 509 6465546 SGTC_384 k007-0144 5.16 µM 0.122884019295063 0.444202544490605 no 1452 0.451099470231956 487 6824886 SGTC_1709 st033179 39.1045 µM 0.122880680247656 0.444203487949413 no 1453 0.451100792299708 489 573381 SGTC_2992 9074591 71.4286 µM 0.121909180059567 0.444478001924082 no 1454 0.451485472611751 497 17741321 SGTC_457 grayanotoxin iii 135 µM 0.118770388557434 0.445365102468173 no 1455 0.452728634550113 493 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_333 3486-0131 40.1 µM 0.118150820173087 0.445540240380635 no 1456 0.4529740783684 513 6744690 SGTC_1990 st072050 59.8 µM 0.115742651032041 0.446221075741882 no 1457 0.453928251375568 513 17233948 SGTC_3271 9137798 49.47 µM 0.115166825663625 0.446383896127983 no 1458 0.454156446481261 504 6498326 SGTC_1128 3448-9350 235 µM 0.111149457042221 0.447520097358264 no 1459 0.455748915313971 465 619386 SGTC_1016 4226-1401 38 µM 0.110934254370514 0.447580973700994 no 1460 0.455834241087569 511 2901613 SGTC_2676 harmalol 100 µM 0.109732540972348 0.447920935991349 no 1461 0.456310746140468 473 5459187 A monoamine oxidase inhibitor SGTC_178 4092-0806 87.505 µM 0.109440173468048 0.448003651962633 no 1462 0.456426685636109 491 2169044 SGTC_1842 st055362 61.2 µM 0.109438072942062 0.448004246247009 no 1463 0.456427518621469 464 676032 SGTC_2296 7971656 126.45 µM 0.107930601549364 0.448430772625646 no 1464 0.457025371189869 488 666570 SGTC_720 r052-1644 49.9 µM 0.107402980674877 0.448580072634069 no 1465 0.457234644975005 484 1422863 YOR257W CDC31 SGTC_2368 9071271 200 µM 0.106927959564272 0.448714494804452 no 1466 0.457423065911703 498 27209959 SGTC_2462 5162487 171.77 µM 0.105319341503967 0.449169747540177 no 1467 0.458061208012674 502 2259986 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.105216413471399 0.449198879342416 no 1468 0.458102043473198 484 77254 SGTC_3261 9137475 49.47 µM 0.103248369693545 0.449755948821792 no 1469 0.458882925772722 514 17027690 SGTC_2181 6316240 54.2555 µM 0.102575469069687 0.449946441138967 no 1470 0.459149956483617 479 12779990 SGTC_467 ro 31-8220 72.8 µM 0.10173018539378 0.45018574993892 no 1471 0.459485420977189 498 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_827 3253-0474 693 µM 0.099711543771782 0.450757321976746 no 1472 0.460286667807487 484 5402065 SGTC_1712 st032288 53.4 µM 0.0995836139022746 0.45079354837147 no 1473 0.460337451681598 498 2883011 SGTC_2719 novobiocin 32.65 µM 0.0995416423654082 0.450805433702815 no 1474 0.460354113117193 479 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_551 k048-0028 34.9 µM 0.099358222002971 0.450857374462295 no 1475 0.460426926291313 501 6836383 SGTC_2441 5730946 39.09 µM 0.0984181753454149 0.451123588943369 no 1476 0.460800121452125 490 1774275 SGTC_15 0266-0086 27.098 µM 0.0982338106060419 0.451175802299728 no 1477 0.46087331765451 513 1712902 YIL048W NEO1 SGTC_1971 st069429 63.5 µM 0.0976263506986349 0.451347845076636 no 1478 0.461114499809594 520 1246522 YGL099W LSG1 SGTC_1299 1079-1439 3.74 µM 0.0975517034800485 0.45136898704507 no 1479 0.461144138271938 477 323161 SGTC_2551 apiole 73.87 µM 0.0970902141093227 0.451499695493925 no 1480 0.461327376077861 501 10659 A possible DNA adduct former. SGTC_1172 0370-0043 85 µM 0.0970442847721081 0.451512704429093 no 1481 0.461345613114549 493 376585 SGTC_1302 1159-0335 255 µM 0.0959243588959807 0.451829926113314 no 1482 0.46179032409228 498 649284 SGTC_1367 1812-0510 76.9 µM 0.0958982092141046 0.451837333441541 no 1483 0.461800708433344 496 1142582 YDR527W RBA50 SGTC_2866 9034245 58.44 µM 0.0940688187525173 0.452355579901347 no 1484 0.462527244774427 503 6462273 SGTC_1719 st032227 49.2 µM 0.0936068761456946 0.452486456100459 no 1485 0.462710723613581 510 3125804 SGTC_3051 9093778 49.47 µM 0.0922035797553773 0.452884065444177 no 1486 0.463268146964775 511 17217378 SGTC_1627 st003713 25.6 µM 0.0920689607805405 0.452922210811464 no 1487 0.463321624694435 500 16195070 YER133W GLC7 SGTC_545 4218-0007 221 µM 0.090517309115487 0.453361915042286 no 1488 0.463938069864992 499 2840508 SGTC_2204 7233102 200 µM 0.0883809153629455 0.453967415882986 no 1489 0.464786964633006 502 2172480 SGTC_2762 leflunomide 42.06 µM 0.0866719733969811 0.454451844615958 no 1490 0.465466127275628 504 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_308 4092-1169 104 µM 0.0855433953547062 0.454771796494488 no 1491 0.465914698689506 506 2268590 YDL196W YDL196W SGTC_961 1252-1571 372 µM 0.0854610814189619 0.454795133646226 no 1492 0.465947417382707 512 6813498 SGTC_1501 4491-0275 38.4 µM 0.0814119408432967 0.455943312645521 no 1493 0.467557176607138 514 5104718 SGTC_2795 7780010 54.55 µM 0.0811159064633284 0.456027271050464 no 1494 0.467674887922463 497 953673 SGTC_1964 st076914 61 µM 0.0807240359992748 0.45613841257705 no 1495 0.467830710615211 513 24208661 SGTC_136 0097-0015 404.482 µM 0.0804961454202704 0.456203048031517 no 1496 0.467921330898776 495 4861337 SGTC_982 1491-0518 27.5 µM 0.0785586543898516 0.456752615473194 no 1497 0.468691837436266 493 3091256 SGTC_2635 hydroquinidine 100 µM 0.0762552204098092 0.457406089834139 no 1498 0.469608025499964 507 442912 An experimental heart treatment. SGTC_369 0957-0393 4.5 µM 0.0752775700504014 0.457683479975388 no 1499 0.469996933672049 505 6997992 SGTC_230 MPP+ 141.667 µM 0.0749683274461036 0.457771226121803 no 1500 0.470119955995471 501 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0737444610490029 0.458118512654268 no 1501 0.470606860138656 523 1241132 A phosphatase inhibitor. SGTC_2008 4012253 172 µM 0.0721846917901409 0.45856116189682 no 1502 0.471227463786282 522 603940 SGTC_862 0452-0056 10.2 µM 0.0719904481579636 0.458616290196314 no 1503 0.471304754696947 521 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1351 1496-0003 46.5 µM 0.0711933440599275 0.458842524692489 no 1504 0.471621939323747 512 3891978 SGTC_2029 5175081 200 µM 0.0703752754025889 0.459074723221605 no 1505 0.471947484908138 517 1380876 SGTC_1621 st003705 32.4 µM 0.0703614550686106 0.459078646070244 no 1506 0.471952984789919 491 24207032 SGTC_1684 st024538 14.6195 µM 0.0693379057726527 0.459369187650563 no 1507 0.472360326942688 524 6732859 SGTC_2545 solidagenone 89.61 µM 0.0686376649779665 0.459567968377534 no 1508 0.472639018616095 507 6708572 An anti ulcer agent SGTC_3180 9109287 49.47 µM 0.0676025252947488 0.459861836965765 no 1509 0.473051022553001 512 18891271 SGTC_2623 humulene 100 µM 0.0656875933908776 0.460405529820425 no 1510 0.47381327505966 507 6187145 An anti-inflammatory. SGTC_1159 4092-0538 61.2 µM 0.0639049721026267 0.460911723233047 no 1511 0.474522946604212 519 717301 SGTC_1411 3909-8223 150 µM 0.0634032152442806 0.461054213646115 no 1512 0.474722713505038 520 X1411 SGTC_1955 wogonin 32.4 µM 0.0619333839122494 0.461471649453889 no 1513 0.475307941000238 520 5281703 A flavanone. SGTC_2333 9017922 200 µM 0.0616964053545484 0.461538955948255 no 1514 0.475402301314696 529 3163164 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0607741935457788 0.461800892407867 no 1515 0.475769521443861 520 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2160 5660466 132.927 µM 0.0592017220396048 0.462247560732996 no 1516 0.476395719030514 526 2859134 SGTC_1706 st031321 9.9705 µM 0.0575462904124197 0.46271784573015 no 1517 0.477055016380338 520 6103185 SGTC_2478 5763493 32.33 µM 0.0564405477362654 0.463032000848709 no 1518 0.477495427998052 515 1365576 YLR208W SEC13 SGTC_1387 3342-1166 1.8 µM 0.0560974639493143 0.463129479875975 no 1519 0.47763208211718 520 3418228 SGTC_547 1120-0019 610 nM 0.0555812755229506 0.463276146603176 no 1520 0.477837690705423 528 3676939 SGTC_3029 9088683 49.47 µM 0.0554623949861377 0.463309925323891 no 1521 0.477885044133973 526 25236615 SGTC_1418 3966-3099 2.4 µM 0.0530776114389632 0.463987593374763 no 1522 0.478835034892997 530 740335 SGTC_1866 st057638 64 µM 0.0529279932231725 0.464030112890231 no 1523 0.478894640141884 514 688802 SGTC_1252 0493-0875 34.8 µM 0.0522433591198757 0.464224682069162 no 1524 0.479167392251809 518 3960963 SGTC_2168 5727979 200 µM 0.0509870466977384 0.464581741247076 no 1525 0.479667921180395 524 695210 SGTC_2985 9022375 71.43 µM 0.050943622243427 0.4645940835136 no 1526 0.479685222546775 501 4939335 SGTC_904 1141-0088 396 µM 0.0504502139060298 0.464734324331292 no 1527 0.479881811195814 517 1378119 SGTC_1355 1499-0035 1.68 µM 0.0493891166856333 0.465035933449315 no 1528 0.480304600602625 519 1548538 SGTC_1344 1488-0097 29.1 µM 0.0489318855375957 0.465165904259579 no 1529 0.480486789152309 525 747966 SGTC_433 pimozide 108 µM 0.0484899825352931 0.46529152148024 no 1530 0.480662873915355 515 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_741 4582-0002 126 µM 0.0480628739827873 0.465412936455041 no 1531 0.480833067131072 527 2912688 SGTC_2773 thioridazine 9.09 µM 0.0478713858777498 0.465467372195296 no 1532 0.480909371998878 531 5452 An antipsychotic. SGTC_3138 9097216 49.47 µM 0.0460032054730593 0.465998487409287 no 1533 0.481653847509118 533 25237486 SGTC_1838 st055369 84.5 µM 0.0459860999888972 0.466003350702078 no 1534 0.481660664395573 511 676036 SGTC_2240 6690706 185.951 µM 0.0451697643430945 0.466235450534096 no 1535 0.4819859971005 527 805876 SGTC_1945 st075991 56.6 µM 0.0446708259465905 0.466377313919077 no 1536 0.482184843998974 509 1084980 SGTC_2351 9026858 72.31 µM 0.0444975693887971 0.466426577036461 no 1537 0.482253894703241 522 1409300 SGTC_1867 st057372 64 µM 0.0422302943420636 0.46707129261741 no 1538 0.483157556351263 505 688837 SGTC_3307 9126885 69.2785 µM 0.041955399746577 0.467149466732528 no 1539 0.483267126316244 505 24824909 SGTC_2310 7668677 200 µM 0.0407191687948175 0.467501039866237 no 1540 0.483759889889917 534 2197143 SGTC_2868 9035608 32.47 µM 0.0406771315563899 0.467512995331801 no 1541 0.483776646438662 530 6462614 SGTC_2148 5546263 113.568 µM 0.0405891386305612 0.467538020771664 no 1542 0.483811721569758 521 792097 SGTC_975 1335-0046 28.5 µM 0.0397045236030826 0.467789614928615 no 1543 0.484164347604384 522 16486740 SGTC_2832 7992762 51.95 µM 0.0392777788107553 0.467910990406537 no 1544 0.484334461441358 530 2985177 SGTC_419 nsc-638432 893 µM 0.0384598790055952 0.468143627185371 no 1545 0.484660509857971 496 368090 SGTC_609 0986-0026 86.3 µM 0.0380102132679533 0.468271531096161 no 1546 0.484839769451873 526 2848610 SGTC_394 menadione 8.33 µM 0.037607668842822 0.46838603449603 no 1547 0.485000246698315 535 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2947 9072639 7.68 µM 0.0365828245611363 0.468677562313854 no 1548 0.485408819188927 518 16488146 SGTC_2117 5521686 200 µM 0.0332225657083166 0.469633540547913 no 1549 0.486748551610151 527 803312 SGTC_787 4152-0075 138 µM 0.0327307995142778 0.469773460591995 no 1550 0.486944631291499 526 9566539 SGTC_860 0443-0016 25.1 µM 0.032575771254552 0.469817570866617 no 1551 0.48700644565573 533 5337942 SGTC_3244 9134489 49.47 µM 0.0312469753213144 0.470195669030462 no 1552 0.487536288648841 530 16584271 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0301858035052133 0.47049763622663 no 1553 0.487959435267423 541 756377 SGTC_50 0929-0078 56.389 µM 0.0290133204696055 0.470831297879734 no 1554 0.488426983434304 531 1377751 SGTC_2098 5376439 882.5 nM 0.0289274906122956 0.470855723886481 no 1555 0.488461210227274 531 2844116 SGTC_3070 9117005 49.47 µM 0.0261278216680634 0.471652531072372 no 1556 0.489577693075975 541 8779016 SGTC_573 3702-0553 84.7 µM 0.0249619606670011 0.471984377677185 no 1557 0.490042652568621 528 1222756 SGTC_2099 5377090 177.372 µM 0.0231344285827658 0.47250459908104 no 1558 0.490771521495778 534 2243829 SGTC_1891 st059073 26.2 µM 0.0211659463407085 0.473064995504746 no 1559 0.49155663953845 543 688754 SGTC_1596 piperlongumine 63 µM 0.0209686156011548 0.473121175470236 no 1560 0.491635345645536 521 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2020 4017018 200 µM 0.0185092762182077 0.473821392693083 no 1561 0.492616288741011 538 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_38 0929-0051 58.268 µM 0.0177016270249417 0.474051362387571 no 1562 0.492938441336856 536 1379719 SGTC_1701 st028638 40.4 µM 0.0171815227225448 0.474199461251861 no 1563 0.493145901373006 536 3490878 SGTC_1370 2001-0092 44.6 µM 0.0171308248259408 0.474213897587496 no 1564 0.493166123931171 535 790957 SGTC_903 1134-0042 114 µM 0.0167358575216233 0.47432636653906 no 1565 0.493323670498299 538 701009 SGTC_355 1311-2252 105 µM 0.0153657688412506 0.474716522071686 no 1566 0.493870186354467 540 5338538 SGTC_1760 st045453 10.4495 µM 0.0151139627102428 0.474788230703215 no 1567 0.49397063080136 546 3323419 YIL048W NEO1 SGTC_299 1273-0059 1.44 µM 0.0146099408762328 0.474931767054264 no 1568 0.494171684213739 538 2848077 SGTC_1570 verbenone 133 µM 0.0127627232185104 0.475457849085203 no 1569 0.49490854831742 543 29025 A natural terpanoid with antifungal properties. SGTC_2212 7123476 200 µM 0.012063322489649 0.475657047525351 no 1570 0.495187547338071 543 1085715 SGTC_2902 5787006 60.46 µM 0.0120038351637921 0.475673990572283 no 1571 0.495211277629281 533 591003 SGTC_1630 st005209 31.3 µM 0.0119557893125902 0.475687674916136 no 1572 0.495230443775349 545 3367314 SGTC_2752 diclazuril 33.15 µM 0.0107226212863434 0.476038913664338 no 1573 0.495722374982012 544 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2645 abamectin 100 µM 0.0075358218284008 0.476946683687212 no 1574 0.496993670509318 544 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2280 7785178 200 µM 0.00685428282194227 0.477140837943728 no 1575 0.497265558191738 540 2954328 SGTC_2514 salinomycin 42.74 µM 0.0063179942030075 0.477293617635857 no 1576 0.497479501753576 542 23682228 A polyether potassium ionophore. SGTC_1983 st071813 46.9 µM 0.00450670086137847 0.477809649469815 no 1577 0.498202092567299 539 11838595 SGTC_3260 9137109 49.47 µM 0.0040344690899066 0.477944192981033 no 1578 0.498390484067397 546 17478346 SGTC_458 nppb 133 µM 0.00211291444027458 0.478491688705739 no 1579 0.499157069722101 546 4549 A chloride channel blocker. SGTC_2000 st075254 36.4 µM 0.000906240338725049 0.478835519106701 no 1580 0.499638462462164 547 17234175 SGTC_909 3448-9333 149 µM 0.000306167682308687 0.47900651002886 no 1581 0.499877856768543 547 3344074 SGTC_427 1354-0053 47.3 µM -0.000247122107779834 0.479164173580694 no 1582 0.499901412543788 549 6813657 SGTC_728 3030-5151 22.5 µM -0.00031942058631317 0.479184775747352 no 1583 0.499872569625056 548 3125388 SGTC_3298 9116858 71.43 µM -0.000776864956642116 0.479315130332721 no 1584 0.499690075753807 548 2506942 SGTC_493 zm226600 134 µM -0.000868416158634538 0.479341219277079 no 1585 0.499653552120882 549 5240098 A potassium channel opener. YCR052W RSC6 SGTC_80 0159-0065 512.242 µM -0.00223250135082294 0.479729947071891 no 1586 0.499109361559936 551 1548079 SGTC_354 2783-3500 4.88 µM -0.00274052268241201 0.479874724510307 no 1587 0.49890669100013 549 6740761 SGTC_3301 9125354 19.7965 µM -0.00400882225506526 0.480236179862368 no 1588 0.498400715591433 551 41905162 SGTC_2327 6189656 200 µM -0.00403567224657286 0.480243832074403 no 1589 0.498390004081241 550 5349088 SGTC_1755 st041960 45.185 µM -0.00472760189348042 0.480441033611117 no 1590 0.49811396674533 550 2257073 SGTC_880 0833-0487 87.2 µM -0.00687831839769548 0.481054023096186 no 1591 0.497255969610371 551 76075 SGTC_2972 9093619 59.92 µM -0.00723402598970044 0.48115540995148 no 1592 0.497114066345903 551 25236256 SGTC_797 k781-0471 270 µM -0.00779438795296013 0.481315131636348 no 1593 0.496890520580511 556 23738129 SGTC_1007 4101-0031 70 µM -0.0090128276669424 0.481662437552921 no 1594 0.496404450656133 552 1146276 SGTC_1165 k072-0275 30.3 µM -0.00961407174594798 0.481833822228076 no 1595 0.496164599378406 551 6153523 YGL055W OLE1 SGTC_3129 9127257 49.47 µM -0.00970827971489201 0.481860676522574 no 1596 0.496127017590409 560 837894 SGTC_3145 9085516 49.47 µM -0.0105770486815645 0.482108325865994 no 1597 0.495780446755561 551 25236195 SGTC_850 0388-0143 75.9 µM -0.0108261017130013 0.48217932164497 no 1598 0.495681094660763 552 67273 SGTC_2698 st077697 67.5 µM -0.0122249060203521 0.4825780792913 no 1599 0.495123089589201 555 3154499 SGTC_1526 st051518 75 µM -0.0126701841136854 0.48270501855337 no 1600 0.494945463094081 562 673993 SGTC_2423 st077119 87.2 µM -0.0131382801448531 0.482838464611627 no 1601 0.49475873534519 548 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0137489740320486 0.483012565733011 no 1602 0.494515125751901 553 165521 SGTC_1852 st056254 31.4 µM -0.0161210514367874 0.483688845494045 no 1603 0.493568909539406 562 442583 SGTC_726 3448-4391 34.2 µM -0.0182729945724992 0.484302405578767 no 1604 0.49271053553927 557 1356692 SGTC_2153 5569715 200 µM -0.0185530741265712 0.484382264373158 no 1605 0.49259881890344 555 2054701 SGTC_348 k064-0012 10.7 µM -0.0187659800747579 0.484442970445855 no 1606 0.49251389650446 556 5066323 SGTC_2889 9059656 51.95 µM -0.0187899517523336 0.484449805535378 no 1607 0.492504334874665 559 3949838 SGTC_1073 triclabendazole 3.09 µM -0.0205186809140583 0.484942733254204 no 1608 0.491814804999386 558 50248 An antihelmetic and likely tubulin inhibitor. SGTC_349 k015-0014 24 µM -0.022537999648116 0.485518548412327 no 1609 0.491009400177458 559 2196908 SGTC_2484 5809818 12.04 µM -0.0232667323940106 0.485726356349915 no 1610 0.490718754115033 558 2870548 SGTC_1659 st012954 42.1 µM -0.0233465247158657 0.485749110439473 no 1611 0.490686930228726 571 24207262 SGTC_3310 9130229 44.1445 µM -0.0235618303041395 0.485810508591331 no 1612 0.49060105934849 578 7761258 SGTC_3292 9120825 59.784 µM -0.0235977120813454 0.485820740940025 no 1613 0.490586748569457 556 24824900 SGTC_3164 9100705 49.47 µM -0.0260678787017871 0.486525176459588 no 1614 0.489601598717206 556 17174235 SGTC_536 3852-0578 10.6 µM -0.0269767291313791 0.486784370695608 no 1615 0.48923914736922 562 2869208 SGTC_724 3910-0327 137 µM -0.0278094142560245 0.487021848320085 no 1616 0.488907078688614 561 2885483 SGTC_2217 6934799 96.0675 µM -0.0281832984875888 0.487128479731302 no 1617 0.488757978904891 567 675606 SGTC_1978 st071761 42 µM -0.0290612818749461 0.487378883324882 no 1618 0.488407857666675 557 5147680 SGTC_2191 5911152 200 µM -0.029702661629401 0.487561809976938 no 1619 0.488152094593206 569 2875902 SGTC_1523 st012844 44.7 µM -0.0319730596680287 0.488209366479409 no 1620 0.48724676759003 574 4274103 SGTC_2255 7941087 197.44 µM -0.0325413449251012 0.488371456122707 no 1621 0.487020172496543 560 935561 SGTC_1284 0929-0043 16 µM -0.0334286593287658 0.488624544955091 no 1622 0.486666377795024 566 1239883 SGTC_2287 7945887 168.79 µM -0.034054309133612 0.488803001910881 no 1623 0.486416921681002 571 1245853 SGTC_1615 st002656 86.5 µM -0.0352671399067969 0.489148949533255 no 1624 0.485933362789046 560 1584458 SGTC_1398 3558-0053 112 µM -0.0355730394577229 0.489236205563271 no 1625 0.485811403053392 578 4532369 SGTC_565 1418-0001 44.5 µM -0.036912836785617 0.489618380807414 no 1626 0.485277252224342 581 2862145 SGTC_873 0591-4978 488 µM -0.038136617378837 0.489967470784642 no 1627 0.484789378044211 563 3305145 SGTC_1836 st055642 81 µM -0.0381629846325644 0.489974992270708 no 1628 0.48477886668382 571 8571 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0397809921374649 0.490436549556018 no 1629 0.484133865155727 566 6857784 SGTC_3205 9113483 49.47 µM -0.0397820847353624 0.490436861237905 no 1630 0.484133429617003 573 17018033 SGTC_408 cantharidin 100 µM -0.0412065759268712 0.490843226153967 no 1631 0.483565605647783 564 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_371 0195-0006 7.36 µM -0.0428487778136558 0.491311709215483 no 1632 0.482911040298798 568 3928593 SGTC_2197 6588183 93.1375 µM -0.043756430392169 0.491570647154628 no 1633 0.482549278653205 569 884136 SGTC_1976 st070609 63.5 µM -0.0439273341142552 0.491619403498557 no 1634 0.482481163426638 561 682556 SGTC_2189 6047310 154.431 µM -0.0443130021585955 0.491729429436103 no 1635 0.482327453816067 565 711535 SGTC_3294 9122953 26.2835 µM -0.0443956434701686 0.49175300597972 no 1636 0.482294517117004 560 16459826 SGTC_2298 7976326 193.81 µM -0.0462953569303284 0.492294978500495 no 1637 0.481537419988097 567 2235818 SGTC_207 4185-0010 4.486 µM -0.0466805381692484 0.49240486928553 no 1638 0.481383920862595 563 3761753 SGTC_2828 7998861 71.43 µM -0.0476279792304912 0.49267517315695 no 1639 0.481006366563144 569 2988188 SGTC_513 4245-1575 41.7 µM -0.04781899039706 0.492729668839795 no 1640 0.480930250860195 570 719745 SGTC_2963 9082507 9 µM -0.0488341522763002 0.493019297823461 no 1641 0.480525732526058 569 16459611 SGTC_3212 9128307 49.47 µM -0.0503602316048909 0.493454700092202 no 1642 0.479917663366711 606 27243542 SGTC_1667 st014849 34.6 µM -0.0503817625409835 0.493460843092268 no 1643 0.479909084655986 565 5348460 SGTC_3251 9135047 49.47 µM -0.0505620989282507 0.493512295000444 no 1644 0.479837232423572 570 17682963 SGTC_2813 7971799 71.43 µM -0.0521163526294687 0.493955744658424 no 1645 0.479217991579434 581 2234054 SGTC_1348 1493-0373 93.8 µM -0.0524229400688827 0.494043219111805 no 1646 0.479095847857114 576 3010129 SGTC_244 nsc-207895 1.295 µM -0.0532855138749744 0.494289327169083 no 1647 0.478752211028559 573 42640 SGTC_3193 9111931 49.47 µM -0.053599579815504 0.494378936461407 no 1648 0.478627095645584 582 17087244 SGTC_1781 st038725 66.3 µM -0.0555585342659896 0.494937871557719 no 1649 0.477846749157217 567 4270275 YIL048W NEO1 SGTC_2664 lyso-paf C-16 73.48 µM -0.0557457060234565 0.49499127653458 no 1650 0.477772193973626 577 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3190 9110366 49.47 µM -0.0562153258828157 0.495125271703667 no 1651 0.477585136090176 582 17123768 SGTC_1855 st056195 39.6 µM -0.057419382966522 0.495468824031014 no 1652 0.477105561549542 566 4028379 SGTC_455 paf C-16 10 µM -0.0576258712347291 0.495527741453658 no 1653 0.477023320822929 585 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_887 0885-0007 9.62 µM -0.0579245786842189 0.495612972003449 no 1654 0.4769043525148 572 5719458 SGTC_107 0358-0022 2.6945 µM -0.0587425714616174 0.49584637186342 no 1655 0.476578575369901 582 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2586 curcumin 80 µM -0.0607730302871767 0.49642573357127 no 1656 0.47576998466068 597 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0609960020674035 0.496489355786791 no 1657 0.475681196508477 574 688798 SGTC_908 3448-7491 47.7 µM -0.0622375629047013 0.496843621268833 no 1658 0.475186824792523 578 1203031 SGTC_718 1130-0073 349 µM -0.0647772219411732 0.497568291986101 no 1659 0.474175688804828 596 6740020 SGTC_287 k060-0039 29.6 µM -0.0656284595214747 0.497811187508682 no 1660 0.473836815265005 580 5861974 SGTC_1567 st069303 68.4 µM -0.0656969267695036 0.497830724262471 no 1661 0.473809559605932 581 5581319 SGTC_1846 st056244 14.8 µM -0.0657754287693373 0.497853124384061 no 1662 0.473778309431936 593 5393182 SGTC_215 1287-0124 461.5 µM -0.0661952739276991 0.49797292504519 no 1663 0.473611179691619 594 5560863 SGTC_2811 7967822 32.47 µM -0.0665548940651879 0.49807554095147 no 1664 0.473468027701144 584 2232244 SGTC_1977 st070720 65.3 µM -0.0666264998482167 0.498095973338588 no 1665 0.473439524393296 603 682188 SGTC_933 2914-0560 114 µM -0.0667564041612404 0.498133040960923 no 1666 0.473387815193214 599 463887 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0672467455168486 0.498272957844996 no 1667 0.473192635889176 596 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_877 0771-0151 33.1 µM -0.0682117183805605 0.498548309477118 no 1668 0.472808549390503 598 6166523 SGTC_491 tetrandrine 80.3 µM -0.0686936807880656 0.49868583603182 no 1669 0.472616724161974 586 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2875 9039966 71.43 µM -0.0690997719424982 0.498801713069622 no 1670 0.472455101279874 605 6463691 SGTC_3186 9110464 49.47 µM -0.0693252823607753 0.49886606191584 no 1671 0.472365350866214 578 17018021 SGTC_1382 3002-2117 298 µM -0.069821464931356 0.499007646500117 no 1672 0.472167881162378 585 1497314 SGTC_1837 st055472 66.5 µM -0.0704780749167158 0.499195008876778 no 1673 0.471906575415306 593 676091 SGTC_3054 9094397 49.47 µM -0.0707741887952857 0.499279504454148 no 1674 0.471788737327717 604 2598354 SGTC_890 0929-0006 47.2 µM -0.0713332736792131 0.499439038433042 no 1675 0.471566257052114 590 1378169 SGTC_968 1309-0633 340 µM -0.0724487743616019 0.499757345014314 no 1676 0.471122385208102 578 3761976 SGTC_3109 9122853 49.47 µM -0.0728306888249556 0.499866323825417 no 1677 0.470970424823227 619 1234709 SGTC_2420 aureobasidin a 50 nM -0.0729499564637935 0.49990035669837 no 1678 0.470922970150349 609 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_95 0471-0001 561.058 µM -0.0736483530369919 0.49990035669837 no 1679 0.47064509770981 573 4015405 SGTC_510 ag-490 170 µM -0.0746885473324435 0.499603538596552 no 1680 0.470231260062898 576 5328779 SGTC_2499 avocadenofuran 51.48 µM -0.076312894877854 0.499140033618048 no 1681 0.469585083565882 623 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_764 1951-2361 146 µM -0.0768529817407098 0.498985920920397 no 1682 0.469370250999171 599 5438930 SGTC_2449 5812982 45.77 µM -0.0769902598738059 0.498946748905042 no 1683 0.469315646731916 573 776185 SGTC_1896 st058441 89 µM -0.078507897129124 0.49851369519098 no 1684 0.468712024306511 582 688759 SGTC_2994 9053520 71.4286 µM -0.0785406878028767 0.498504338477801 no 1685 0.468698982989193 606 4647384 SGTC_1223 0764-0573 147 µM -0.0812367616932966 0.497735025765244 no 1686 0.467626832256317 579 1609797 SGTC_798 1287-0182 476 µM -0.081359077409298 0.497700123696976 no 1687 0.46757819633749 621 1649755 SGTC_1331 1472-0049 76.2 µM -0.0820369273786145 0.497506703531923 no 1688 0.467308674303646 590 24051409 SGTC_1758 st042942 75.2445 µM -0.0839493305172999 0.496961014802723 no 1689 0.466548358936706 585 669317 SGTC_3354 9151612 71.43 µM -0.0856495935977425 0.496475863262254 no 1690 0.465872486642636 593 27261949 SGTC_2907 7721985 69.9 µM -0.0857762273393771 0.49643972990383 no 1691 0.465822152324659 594 3267881 SGTC_2399 5884133 200 µM -0.0858401715324627 0.496421484237114 no 1692 0.465796736025612 594 722445 SGTC_1980 st071811 45.7 µM -0.0865042472421616 0.496231999082334 no 1693 0.465532789959477 585 4974850 SGTC_57 miconazole 162.5 nM -0.0877746118610354 0.495869519871082 no 1694 0.46502790833254 606 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_337 1315-0038 354 µM -0.0881164950509253 0.495771969275631 no 1695 0.464892043110429 590 1626437 SGTC_2692 st077426 47.7 µM -0.088623752807222 0.495627232307617 no 1696 0.464690465174337 590 25238571 SGTC_1246 0422-0085 105 µM -0.0936781946228147 0.494185071892349 no 1697 0.462682396131142 594 264295 SGTC_1782 st039423 80.636 µM -0.0937836012215287 0.49415499746042 no 1698 0.46264052929697 622 2068169 SGTC_2914 7968218 45.32 µM -0.0954351559448592 0.493683783115854 no 1699 0.461984596548104 597 2977111 SGTC_2618 avocadyne 43.43 µM -0.095816284969012 0.493575042283213 no 1700 0.461833241666989 593 3015189 SGTC_3023 9089636 49.47 µM -0.0961152948931672 0.493489731381031 no 1701 0.461714501989743 576 17249241 SGTC_3001 9076041 71.4286 µM -0.0963970641843372 0.493409339698229 no 1702 0.461602611854207 605 16004211 SGTC_1027 k015-0025 8.67 µM -0.0967964298286646 0.493295397023211 no 1703 0.461444029603041 586 3598955 SGTC_2539 epi(13)torulosol 80 µM -0.0970548858742208 0.493221657437904 no 1704 0.461341403756623 613 6708597 SGTC_640 3381-0960 37.1 µM -0.0972542823292187 0.493164768186206 no 1705 0.461262230621556 606 1745025 SGTC_2715 st079500 56.4 µM -0.0976769985929868 0.493044164638026 no 1706 0.461094390332539 594 28246688 SGTC_1674 st016616 23.6 µM -0.100146239166127 0.492339688185939 no 1707 0.4601141131381 584 625830 SGTC_1797 st048695 56.8 µM -0.100374843470767 0.492274468356627 no 1708 0.460023370444538 589 592262 YIL048W NEO1 SGTC_2319 6033012 152.6 µM -0.101550008544537 0.491939202090333 no 1709 0.459556930810935 587 847246 SGTC_851 0394-0702 453 µM -0.10229271581477 0.491727315891955 no 1710 0.459262168458839 592 762646 SGTC_1692 fluoroquinolonic acid 71 µM -0.103895925459351 0.491269945886704 no 1711 0.458625970310971 629 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3268 9137683 49.47 µM -0.105789219773618 0.490729834204106 no 1712 0.457874795083003 590 1953228 SGTC_1603 st002045 67.8 µM -0.107917249035274 0.490122778580882 no 1713 0.457030667139821 622 5887985 SGTC_1377 2944-0135 198 µM -0.108255126184795 0.490026395591402 no 1714 0.456896658735529 605 1894137 SGTC_336 4111-0029 111 µM -0.109197980430296 0.489757439657994 no 1715 0.456522731057487 621 3131175 SGTC_535 2293-4129 48.2 µM -0.110019595336033 0.489523071908713 no 1716 0.456196917210554 633 396118 YIL048W NEO1 SGTC_1685 st024049 53.0905 µM -0.11018389054474 0.489476206712437 no 1717 0.456131768980788 606 1941139 SGTC_2893 9048488 25.97 µM -0.111309793405333 0.489155046947276 no 1718 0.455685344826512 585 6467338 SGTC_139 0099-0334 718.624 µM -0.111629409484247 0.489063878875916 no 1719 0.455558626179796 600 97690 SGTC_454 lyso-paf C-16 6.67 µM -0.113961035526286 0.488398817757202 no 1720 0.454634340651395 623 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2817 7995342 71.43 µM -0.114077776048149 0.488365520118819 no 1721 0.454588069672268 618 18879975 SGTC_641 4092-0595 30 µM -0.114316942229684 0.488297303536399 no 1722 0.454493276292177 591 786260 SGTC_1187 1391-0724 117 µM -0.1166098773806 0.487643314858792 no 1723 0.453584605056094 598 6997986 SGTC_3346 9158254 43.5805 µM -0.117067520494603 0.487512790267523 no 1724 0.453403273805815 592 17639500 SGTC_3113 9123498 49.47 µM -0.11733895982478 0.487435373569338 no 1725 0.453295726391166 587 8897275 SGTC_1177 0983-0204 23.6 µM -0.117520226217679 0.487383675187595 no 1726 0.453223908448405 594 766818 SGTC_275 trichlorophene 5.69 µM -0.117629825959754 0.487352416714463 no 1727 0.453180485652951 599 62616 SGTC_2005 4024620 188 µM -0.119172635177006 0.486912407037732 no 1728 0.452569293044674 593 236743 SGTC_1565 sinapyl alcohol 95.1 µM -0.12005788554088 0.486659940512978 no 1729 0.452218646741767 603 5280507 A phenol propionate derived from cinnamic acid. SGTC_1093 fluphenazine 7.97 µM -0.12156139240731 0.486231164343021 no 1730 0.451623195529004 626 6602611 An atypical antipsychotic. SGTC_1611 st001856 99.4 µM -0.121609087068092 0.486217562844589 no 1731 0.451604308234646 626 647478 SGTC_3150 9097574 49.47 µM -0.122138595451214 0.486066559445424 no 1732 0.451394627966939 630 17217476 SGTC_1903 st060211 78.3 µM -0.122141897928838 0.486065617662337 no 1733 0.451393320259799 589 688960 SGTC_226 1,3-diallylurea 8.28947 mM -0.122162329846791 0.486059790997865 no 1734 0.451385229689839 601 74537 YKL182W FAS1 SGTC_3232 9132874 49.47 µM -0.126187222665784 0.484912053330815 no 1735 0.449791862675404 624 3784940 SGTC_2395 5646831 180.19 µM -0.130291366210095 0.483741845308349 no 1736 0.448167955305095 624 6808628 SGTC_2667 digitoxin 100 µM -0.130694709404127 0.483626848088549 no 1737 0.448008408864841 602 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2857 9024691 58.44 µM -0.131550974681212 0.48338272273338 no 1738 0.447669732468576 642 16478292 SGTC_489 paxilline 115 µM -0.131577166362939 0.483375255456477 no 1739 0.447659373540297 649 105008 A toxic potassium channel blocker. SGTC_342 k048-0088 23.3 µM -0.132028664208454 0.483246533849311 no 1740 0.447480809723354 597 6820570 SGTC_2421 5690543 90.72 µM -0.133407516446547 0.482853435251349 no 1741 0.446935550640121 615 3397993 SGTC_2922 7999257 32.47 µM -0.13506300957566 0.482381490831094 no 1742 0.44628102810986 590 2988377 SGTC_1054 3429-0080 167 µM -0.135077216631156 0.482377440820168 no 1743 0.446275411781093 648 1162877 SGTC_781 4335-2806 94.4 µM -0.135101847035716 0.482370419425313 no 1744 0.446265674922751 648 845254 SGTC_2531 methyl deoxycholate 70.07 µM -0.135754138804251 0.482184472463801 no 1745 0.446007823628896 624 16667744 Haematoxylin. SGTC_169 k015-0017 16.025 µM -0.136215849498746 0.482052856247746 no 1746 0.445825322932059 636 1840002 SGTC_1632 st005650 90 µM -0.137047716349036 0.481815727490404 no 1747 0.445496539356665 610 2759605 SGTC_1887 st057648 70.8 µM -0.137956841073837 0.481556583261437 no 1748 0.445137263573987 596 688672 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.138192809745712 0.481489322121399 no 1749 0.445044018783979 652 65057 A dermal irritant. YDR527W RBA50 SGTC_2900 5328528 85.29 µM -0.138314870757952 0.481454529731345 no 1750 0.444995786652649 597 795359 SGTC_453 enantio-paf c16 10 µM -0.138943579151463 0.481275324320672 no 1751 0.444747366875381 631 13871343 A lipid and platelet activating factor SGTC_1728 st035614 33.7865 µM -0.139480398195168 0.481122313805326 no 1752 0.444535272248669 622 15945546 SGTC_1409 3909-8004 61.9 µM -0.142300673231675 0.480318491855645 no 1753 0.443421257388035 598 2119279 SGTC_1817 st052116 64.4 µM -0.14333453445117 0.480023845310224 no 1754 0.443012991430753 612 4361398 SGTC_1902 st060212 70.5 µM -0.145730711289085 0.479340986189938 no 1755 0.442066988038435 604 688944 SGTC_1922 5578187 25 µM -0.148295953229881 0.478610014383554 no 1756 0.441054604452356 595 1350412 SGTC_738 1315-0003 72.4 µM -0.148966815203395 0.478418862432559 no 1757 0.440789909188276 643 6251474 SGTC_1035 k081-0041 55.2 µM -0.149771375154499 0.47818962181994 no 1758 0.440472496951509 606 731709 SGTC_459 nigericin 15.3 µM -0.150569992362686 0.477962081589226 no 1759 0.440157467048021 657 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2036 5160441 105 µM -0.150644363370481 0.477940892332334 no 1760 0.440128131899911 604 134534 YIL048W NEO1 SGTC_27 0485-0001 32.618 µM -0.151592232958625 0.477670837574932 no 1761 0.439754279903438 613 2054479 SGTC_202 3594-0513 34.79 µM -0.15240499984693 0.477439282693673 no 1762 0.439433756918907 619 708429 SGTC_2673 kobusone 100 µM -0.158613533191607 0.475670746914113 no 1763 0.436986682918596 607 6710676 An epoxy ketone and protein crosslinker. SGTC_820 1582-0060 59.9 µM -0.158628624922431 0.475666448519108 no 1764 0.436980737457368 628 3848840 SGTC_1271 0832-2808 169 µM -0.158774559782407 0.475624883805654 no 1765 0.43692324643943 646 3663794 SGTC_2407 paclitaxel 400 µM -0.159066944976137 0.475541608361655 no 1766 0.436808065341986 709 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2920 7982904 15.77 µM -0.159260383637845 0.475486514878282 no 1767 0.436731865804136 641 6456808 SGTC_1516 st013856 110 µM -0.15927513754783 0.475482312819765 no 1768 0.436726054026483 646 5281404 A mutagen and neurotoxin. SGTC_1186 1319-0216 26 µM -0.159781017609458 0.475338234860951 no 1769 0.436526788854253 609 4565136 SGTC_1600 coumarin 106 71.1 µM -0.160155447668436 0.475231596800537 no 1770 0.436379311951725 656 100336 A hepatotoxic, DNA x-linker. SGTC_1247 0448-0043 5.84 µM -0.160640104799588 0.475093568593913 no 1771 0.436188433007202 636 3089013 YGL099W LSG1 SGTC_2011 4012611 177 µM -0.161273835071763 0.474913089528517 no 1772 0.435938865037159 638 2049887 SGTC_2106 5357045 167.29 µM -0.161492211895651 0.474850899520812 no 1773 0.435852872428629 621 668842 SGTC_579 4491-1009 110 µM -0.162089711094146 0.474680745041125 no 1774 0.435617604205786 620 1271041 SGTC_2069 5228469 200 µM -0.162203877364378 0.474648233551682 no 1775 0.435572653270343 628 2835210 SGTC_2800 7887935 81.82 µM -0.162566994481169 0.474544828666635 no 1776 0.435429687910141 633 2961002 SGTC_414 piperonyl butoxide 100 µM -0.165399395164891 0.473738305134517 no 1777 0.434314814853807 637 5794 A potent inhibitor of cytochrome P450. SGTC_2931 9014674 55.67 µM -0.166297742790149 0.473482523786376 no 1778 0.433961321153556 624 2996810 SGTC_1298 1079-1278 263 µM -0.168318422474304 0.472907227402755 no 1779 0.433166390792014 654 2840950 SGTC_356 1634-0012 32.5 µM -0.169270311759437 0.47263623984787 no 1780 0.43279201338741 646 735457 SGTC_2936 9038235 15.59 µM -0.170978888179919 0.472149867498473 no 1781 0.432120182966356 608 4749415 SGTC_1736 st036774 51 µM -0.172491139987103 0.471719416565764 no 1782 0.431525713117042 679 1272247 SGTC_1998 st075797 76.8 µM -0.172783868021298 0.471636097565802 no 1783 0.431410658887729 636 24208315 SGTC_1912 st060209 90.8 µM -0.176872576219138 0.47047246247209 no 1784 0.429804239990734 651 688787 SGTC_1433 4060-0023 7.6 µM -0.177873926712224 0.470187518927072 no 1785 0.42941099387988 614 3840627 SGTC_1265 0819-1001 68.8 µM -0.179003947495543 0.469865979401361 no 1786 0.428967301052846 637 3106768 SGTC_132 0417-1715 25.805 µM -0.179736120909586 0.469657655044165 no 1787 0.428679867408615 639 6769098 SGTC_3170 9103054 49.47 µM -0.181730190704378 0.469090327215756 no 1788 0.427897235859605 656 16432970 SGTC_706 4262-0057 46.9 µM -0.183669723184078 0.468538575855173 no 1789 0.427136281097077 627 883298 SGTC_3151 9099821 49.47 µM -0.18418001639315 0.468393419439377 no 1790 0.426936117952339 668 17174189 SGTC_1181 1222-0449 220 µM -0.184469434501659 0.468311094332401 no 1791 0.426822601696939 642 658318 SGTC_1680 diphenhydramine 100 µM -0.18775829557988 0.467375672412188 no 1792 0.425533064780596 618 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2967 9089538 49.85 µM -0.187937495375056 0.467324709313931 no 1793 0.425462824678199 635 728216 SGTC_76 0433-0009 400.328 µM -0.187984198262602 0.467311427445592 no 1794 0.425444519155131 702 2841569 SGTC_734 2023-0417 80 µM -0.190140710526237 0.466698175227374 no 1795 0.424599434777959 658 3935732 SGTC_1660 st012960 28.1 µM -0.190330337533284 0.466644254331017 no 1796 0.424525141111152 651 24207266 SGTC_3270 9137563 49.47 µM -0.191692612884974 0.466256906108532 no 1797 0.423991496372621 620 17015724 SGTC_806 3966-4455 5.86 µM -0.191849539218139 0.466212287853494 no 1798 0.423930032481095 676 714982 SGTC_3335 9143315 29.6265 µM -0.193668456229838 0.4656951533727 no 1799 0.423217746226984 624 4899691 SGTC_1717 st033143 58.0435 µM -0.193814946204104 0.465653507462943 no 1800 0.423160391771288 652 674616 SGTC_2915 7971052 15.16 µM -0.195072070872391 0.465296132642879 no 1801 0.422668263376566 623 5741558 SGTC_1343 1487-0095 224 µM -0.195284762473741 0.465235671533012 no 1802 0.422585012605294 677 4560101 YGL055W OLE1 SGTC_2808 7946468 45.46 µM -0.19591605062847 0.465056222152225 no 1803 0.422337937066932 676 2970879 SGTC_3104 9120930 49.47 µM -0.195943346159878 0.465048463309993 no 1804 0.422327254744698 661 17014836 SGTC_2140 5586273 200 µM -0.200253713090538 0.463823396362985 no 1805 0.420641080428653 622 854421 SGTC_1932 st074806 40.9 µM -0.20075771287543 0.463680174701324 no 1806 0.420444014954931 624 17251235 SGTC_2864 9034755 47.6 µM -0.200898772406337 0.463640090644689 no 1807 0.420388863811381 621 4930451 SGTC_3289 9119912 71.43 µM -0.201892954837179 0.463357590166339 no 1808 0.420000204947527 693 17014829 SGTC_319 1348-1596 45.5 µM -0.202507928232059 0.463182852526473 no 1809 0.41975983048957 669 5380505 SGTC_1988 st071872 53.4 µM -0.202778201903802 0.463106059606085 no 1810 0.41965419816771 626 16414116 SGTC_784 4579-0127 173 µM -0.203027544585546 0.463035215031878 no 1811 0.419556751536244 680 1948547 SGTC_314 1671-0008 2.74 µM -0.204618457772529 0.46258322397992 no 1812 0.418935116650735 661 3913060 SGTC_2044 5102272 200 µM -0.205298613377656 0.46239000108634 no 1813 0.418669413675417 629 592666 SGTC_963 1269-2853 151 µM -0.205808869999463 0.462245049991302 no 1814 0.41847010613416 622 3668223 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.207454262568936 0.461777669522987 no 1815 0.417827554398793 678 5393153 SGTC_3315 9136395 68.55 µM -0.207525797859249 0.461757350824632 no 1816 0.417799623702516 691 16876844 SGTC_3240 9133527 49.47 µM -0.207586194331514 0.461740196044978 no 1817 0.417776042440414 681 17617455 SGTC_1981 st071826 47 µM -0.208085691438228 0.461598323556339 no 1818 0.417581029606181 626 11838600 SGTC_2885 9057732 51.95 µM -0.208718312840323 0.461418646703257 no 1819 0.417334071701465 655 6471414 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.208931469788275 0.461358107732287 no 1820 0.417250868461697 627 688664 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.209028000571157 0.461330692198582 no 1821 0.417213190055417 636 140250 A respiratory chain inhibitor. SGTC_2206 7254556 146.969 µM -0.212180183673268 0.460435548084169 no 1822 0.415983232955797 637 4398905 SGTC_2135 5326629 150.42 µM -0.212258451408413 0.460413324463486 no 1823 0.415952703914687 641 5020077 SGTC_681 1642-0006 26.6 µM -0.212263493736764 0.460411892730977 no 1824 0.415950737126095 655 4446530 SGTC_1063 disulfiram 1.84 µM -0.212761360437574 0.460270529627774 no 1825 0.415756551786208 623 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_128 0906-2981 13.371 µM -0.215345008640036 0.459537015659367 no 1826 0.4147491704267 657 6740226 SGTC_290 2043-6722 48.1 µM -0.215857860541411 0.459391430081942 no 1827 0.414549272558072 644 773758 YLR208W SEC13 SGTC_1634 st006576 41 µM -0.216295709650681 0.459267140192986 no 1828 0.414378626560289 638 3915356 SGTC_2764 methyldopa 94.69 µM -0.217208387636643 0.459008075978262 no 1829 0.414022974167899 669 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1038 k292-0204 154 µM -0.217653435789652 0.458881755089806 no 1830 0.41384957333918 626 4454212 SGTC_497 capsazepine 133 µM -0.219792573133578 0.45827464809809 no 1831 0.413016351995691 631 2733484 A calcium channel blocker. SGTC_3042 9091578 49.47 µM -0.222988076659805 0.457367916312868 no 1832 0.411772393167068 618 25236497 SGTC_1157 4092-0394 27.6 µM -0.223066125812702 0.457345772435255 no 1833 0.411742020906329 647 3659885 SGTC_317 4495-0002 170 µM -0.22448776825159 0.456942451438446 no 1834 0.411188891791436 656 15991618 SGTC_1260 0700-1617 7.75 µM -0.22564533734945 0.456614080978287 no 1835 0.410738637994419 624 2853078 SGTC_2798 7813637 45.45 µM -0.225810759571445 0.456567157665624 no 1836 0.410674304138944 654 956368 SGTC_1648 st011736 69.8 µM -0.226129737865179 0.456476678677462 no 1837 0.410550258042522 651 2855514 SGTC_2803 7707263 71.43 µM -0.229409930785505 0.455546375530821 no 1838 0.40927515915957 645 2199229 SGTC_1368 1852-0141 284 µM -0.230849725516144 0.455138108654775 no 1839 0.408715774503945 663 2838987 SGTC_2602 kawain 100 µM -0.230857014755099 0.455136041845024 no 1840 0.408712942983088 637 5369129 SGTC_442 cape 100 µM -0.230905536835539 0.455122283799221 no 1841 0.408694094595973 664 5281787 SGTC_105 0111-0055 734.78 µM -0.231027584380637 0.455087678437047 no 1842 0.408646686198595 683 5179370 SGTC_3159 9100096 49.47 µM -0.232250538707286 0.454740940815397 no 1843 0.408171713241465 624 25236875 SGTC_662 k832-1615 104 µM -0.233088110018926 0.454503488633039 no 1844 0.407846493741067 656 5878478 SGTC_2769 toremifene 3.73 µM -0.234074943980631 0.454223741230174 no 1845 0.407463398716773 645 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2119 5528445 120.635 µM -0.234989011030175 0.453964642023773 no 1846 0.40710863118433 651 791935 SGTC_1446 4239-0190 62 µM -0.236827003813759 0.453443708504289 no 1847 0.406395500696138 674 1340085 SGTC_487 nimodipine 119 µM -0.239203800587129 0.452770183230051 no 1848 0.405473777879631 661 4497 L-type voltage-gated calcium channels inhibitor SGTC_1327 1436-0082 2.18 µM -0.239762432578198 0.452611900422315 no 1849 0.405257216006461 659 15992205 SGTC_1313 1220-0047 237 µM -0.240382542961889 0.452436207144477 no 1850 0.405016855104402 647 3528706 SGTC_2754 granisetron 64.02 µM -0.241039391136073 0.452250115259734 no 1851 0.404762293347245 684 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_665 3914-0008 307 µM -0.241364799529673 0.452157927577479 no 1852 0.404636196123502 679 1069549 SGTC_899 1083-0020 478 µM -0.242138214428114 0.45193883072184 no 1853 0.40433653411826 696 767123 SGTC_2970 9090938 41.86 µM -0.243364186272635 0.451591561277638 no 1854 0.40386164255688 652 17217104 SGTC_85 0868-0259 160.055 µM -0.243744259144955 0.451483909140572 no 1855 0.403714446541716 677 83173 SGTC_3192 9110362 49.47 µM -0.244418657465867 0.451292900820511 no 1856 0.403453296663966 640 16649480 SGTC_1103 duloxetine 36.1 µM -0.245327990323548 0.451035370381615 no 1857 0.403101240341696 660 60835 A selective serotonin reuptake inhibitor. SGTC_1883 5-benzylidenerhodanine 20 µM -0.246950101279246 0.450576026648112 no 1858 0.402473420789493 638 1273210 SGTC_2050 5263056 171 µM -0.246981554134558 0.450567120590236 no 1859 0.402461249800425 666 763468 YGL055W OLE1 SGTC_1770 st043884 66.3 µM -0.247651969974266 0.450377294394759 no 1860 0.40220184835736 655 670149 SGTC_2371 9071574 200 µM -0.248142412077041 0.450238434399725 no 1861 0.402012110734854 689 45596039 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.248328822299633 0.45018565724355 no 1862 0.401940000156769 707 6728940 SGTC_2355 9061122 103.12 µM -0.248963459811314 0.450005982919324 no 1863 0.401694523222808 680 5302957 SGTC_3207 9114163 49.47 µM -0.249270976993046 0.449918924396754 no 1864 0.401575589934901 717 849233 SGTC_1056 3448-1962 115 µM -0.249305484013871 0.449909155563651 no 1865 0.401562244799069 659 715507 SGTC_1068 loratadine 26.9 µM -0.249316017861278 0.449906173469396 no 1866 0.401558170995191 673 3957 A H1 histamine antagonist. SGTC_1724 st037281 8.293 µM -0.249809386947014 0.449766505630201 no 1867 0.401367380063012 645 574124 YDL195W SEC31 SGTC_2048 5246248 200 µM -0.24988697486645 0.449744541834273 no 1868 0.401337378149976 638 677046 SGTC_1149 3909-7961 23.3 µM -0.250528606792186 0.449562912858292 no 1869 0.401089292438735 640 735261 SGTC_425 3825-7017 13.1 µM -0.250574185568135 0.449550011117516 no 1870 0.401071671011217 682 3397440 SGTC_1008 4106-0037 6 µM -0.251287197064866 0.449348189711118 no 1871 0.400796036463525 699 2905394 SGTC_668 1682-0499 62.6 µM -0.251366526844546 0.449325735836398 no 1872 0.400765372367462 643 682214 SGTC_7 0192-1582 4.227 µM -0.252044529222966 0.449133837475081 no 1873 0.400503322607732 663 252616 SGTC_1750 st081859 2.357 µM -0.253010523289838 0.448860447966127 no 1874 0.400130040652261 681 5291695 SGTC_2696 st077691 74.316 µM -0.253070314303865 0.448843527089472 no 1875 0.400106939046642 690 757133 SGTC_645 0845-0943 5.41 µM -0.254558980201693 0.448422264227217 no 1876 0.399531872325925 677 1885106 SGTC_1106 tegaserod maleate 11.7 µM -0.254912886118339 0.448322124424462 no 1877 0.399395191650386 668 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1924 st058459 75.1 µM -0.255482910371673 0.448160839567215 no 1878 0.399175070653693 665 688683 SGTC_96 0929-0093 37.281 µM -0.258331192379457 0.447355064592983 no 1879 0.398075657497816 660 6991579 SGTC_2862 9027634 71.43 µM -0.259115429901867 0.447133242901137 no 1880 0.397773089964331 645 5012562 SGTC_2555 cholic acid 100 µM -0.259659506468545 0.446979360480755 no 1881 0.397563215301162 665 6708657 Influences liver metabolism. SGTC_1043 0916-0009 19.3 µM -0.259927620429327 0.446903532130232 no 1882 0.397459802657562 704 3101130 SGTC_2141 5621638 7.665 µM -0.260561828116978 0.446724172391533 no 1883 0.39721521487417 692 2856238 SGTC_2077 5212015 200 µM -0.260596569824986 0.446714347433033 no 1884 0.397201817595094 659 780900 SGTC_686 1319-0111 510 µM -0.262339357562263 0.446221528985279 no 1885 0.39652991064832 707 4562600 SGTC_1568 digitonin 820 nM -0.263189377453298 0.44598119389584 no 1886 0.396202308918324 694 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2306 7482397 179.52 µM -0.26336121405704 0.445932611129048 no 1887 0.396136091167124 702 891448 SGTC_1254 0550-0035 264 µM -0.263524750654107 0.445886375748219 no 1888 0.396073074631394 687 15121435 SGTC_224 benfluorex 43.875 µM -0.26436603197417 0.445648538720456 no 1889 0.395748941618486 685 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1064 honokiol 6.76 µM -0.267008770102753 0.444901542903403 no 1890 0.394731204299587 669 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3071 9117417 49.47 µM -0.267859818699521 0.444661027195807 no 1891 0.394403611910199 671 45595590 YGL055W OLE1 SGTC_692 k241-0027 77.8 µM -0.268557417972136 0.444463893148013 no 1892 0.394135142132885 671 3600480 SGTC_1594 piperine 70.1 µM -0.269714265277711 0.444137010850247 no 1893 0.393690042519021 673 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_715 0868-0130 184 µM -0.270098037150883 0.444028579483567 no 1894 0.393542416069761 662 2876258 SGTC_2113 5491891 107.031 µM -0.270719226461381 0.443853076791204 no 1895 0.393303494121778 690 789979 SGTC_735 3076-0345 636 µM -0.270942604726163 0.443789969111606 no 1896 0.393217588148726 649 2888990 SGTC_3233 9132340 49.47 µM -0.272378232876106 0.44338441690958 no 1897 0.39266560392633 707 17682950 SGTC_2388 9080168 200 µM -0.273470724695653 0.443075837380812 no 1898 0.39224569662562 679 15943073 SGTC_2372 9071633 200 µM -0.273520469201843 0.443061787627948 no 1899 0.392226579939451 658 21321366 SGTC_302 1094-0063 18.9 µM -0.273905676732457 0.442952992699793 no 1900 0.392078554482184 679 5440289 SGTC_1326 1431-2094 10.8 µM -0.274647495114948 0.442743491583984 no 1901 0.391793536558482 685 616278 SGTC_3132 9126706 49.47 µM -0.275004177300762 0.442642764650482 no 1902 0.391656514490743 709 850858 SGTC_927 2425-1185 123 µM -0.27785748398843 0.44183712575956 no 1903 0.390560881013046 675 730375 SGTC_2390 9097792 176.6 µM -0.279819612616964 0.441283252790611 no 1904 0.38980795192655 664 4497149 SGTC_382 3229-0966 23.2 µM -0.280563495971208 0.441073298103585 no 1905 0.389522608907373 706 5722370 SGTC_689 0833-0039 98 µM -0.282040256508677 0.440656544253664 no 1906 0.388956321264497 710 5374726 SGTC_1877 wortmannin 25 µM -0.283297088699767 0.440301907723726 no 1907 0.388474554398205 683 312145 A covalent inhibitor of PI 3-kinase. SGTC_2126 5251174 33.877 µM -0.285735999518172 0.439613864513671 no 1908 0.387540165024393 688 790722 SGTC_249 wiskostatin 11.211 µM -0.285749807327588 0.439609969697975 no 1909 0.387534876859444 667 2775510 A n-wasp and actin depolymerizer. SGTC_277 nystatin 15.5 µM -0.286074270347326 0.439518448995336 no 1910 0.38741061884261 703 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1653 st012112 65 µM -0.286932036673113 0.439276515965636 no 1911 0.387082179843642 675 720429 SGTC_631 k072-0230 41.5 µM -0.287126991967221 0.439221531976396 no 1912 0.387007542664305 687 5773147 SGTC_307 1501-1223 22.3 µM -0.287539336608617 0.439105240700156 no 1913 0.386849693362071 691 2830329 SGTC_1445 4239-0156 97.7 µM -0.289158815054277 0.438648559109576 no 1914 0.386229923511044 712 4008346 SGTC_3306 9127676 59.7925 µM -0.289969679224457 0.438419931731946 no 1915 0.385919716990551 652 41905287 SGTC_556 4058-0063 51.5 µM -0.290296783950519 0.438327708662631 no 1916 0.385794599502599 692 6615692 SGTC_2563 tomatine 8.54 µM -0.290933141433022 0.438148305261914 no 1917 0.385551226949911 744 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2297 7971671 152.32 µM -0.293138089406595 0.437526779688708 no 1918 0.384708301875785 705 909016 SGTC_1485 3909-9022 254 µM -0.294272320581552 0.437207125193297 no 1919 0.384274910857261 681 714516 SGTC_2076 5212012 200 µM -0.295007661898901 0.436999909645889 no 1920 0.383994013352018 659 604802 SGTC_1287 0971-0001 34.6 µM -0.295702740507189 0.436804055818896 no 1921 0.38372855205779 655 4665869 SGTC_3312 9133330 71.43 µM -0.295841978314871 0.43676482433646 no 1922 0.383675381536074 701 17617324 SGTC_1112 tnp00069 1.16933 µM -0.296769731416573 0.436503437599447 no 1923 0.383321157884605 684 145826 SGTC_1001 4048-4355 44.4 µM -0.29868310341755 0.435964448589343 no 1924 0.382590925201033 708 21824233 SGTC_2473 5854593 8.94 µM -0.299463917335408 0.435744530630846 no 1925 0.382293049639239 671 2872951 SGTC_3225 9130819 49.47 µM -0.300320125566116 0.435503400538469 no 1926 0.381966491685326 714 4547121 SGTC_271 rotenone 740 µM -0.300446214249001 0.435467892770379 no 1927 0.381918408529088 713 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.30161580104121 0.435138550878058 no 1928 0.381472480585484 675 279621 SGTC_2270 7924575 90.91 µM -0.30222963755288 0.434965719720179 no 1929 0.381238506254343 708 1262135 SGTC_3053 9095903 49.47 µM -0.302619957155021 0.434855828206696 no 1930 0.381089751801628 711 17174018 SGTC_3252 9135871 49.47 µM -0.302983398734794 0.434753508519945 no 1931 0.380951256610784 695 17682838 SGTC_1558 st069300 45.6 µM -0.303907734139416 0.434493300131772 no 1932 0.380599092663544 695 24208000 SGTC_2629 bisabolol 100 µM -0.305218036628742 0.434124487327955 no 1933 0.380100048086887 703 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1314 1222-0010 41.1 µM -0.306692607156248 0.433709506335307 no 1934 0.379538678710514 688 3526027 SGTC_2977 9011197 71.43 µM -0.306971619813299 0.433630993407943 no 1935 0.37943248704384 693 2704722 SGTC_2012 4023501 200 µM -0.308058228249056 0.433325251587887 no 1936 0.379019012766434 727 3477460 SGTC_1948 st076329 66.6 µM -0.309661844635353 0.432874110848204 no 1937 0.378409060496576 712 24208413 SGTC_1130 3454-2858 15.9 µM -0.309730198798304 0.432854882909777 no 1938 0.378383067994327 724 715628 YIL048W NEO1 SGTC_1145 3546-0597 10.2 µM -0.310281878377528 0.432699701974446 no 1939 0.378173305274005 673 875334 SGTC_3239 9133757 49.47 µM -0.310570474972716 0.432618527301825 no 1940 0.378063587749195 696 17036923 SGTC_90 0870-0863 4.608 µM -0.311216014976734 0.432436964085286 no 1941 0.377818204485884 697 1738164 SGTC_179 1273-0063 6.77 µM -0.311747512973633 0.432287486788829 no 1942 0.377616207971743 725 3108139 SGTC_1385 3091-4834 14.1 µM -0.312015035925624 0.432212252903295 no 1943 0.377514548179952 678 4072814 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.312438855728747 0.432093069618373 no 1944 0.377353512331813 678 16725076 SGTC_1504 k297-0033 30 µM -0.312971056065987 0.431943417162187 no 1945 0.37715132609165 665 4388117 SGTC_2598 perillyl alcohol 100 µM -0.315510893262891 0.431229360688648 no 1946 0.37618689075016 680 10819 An apoptosis inducer. SGTC_280 3448-3607 3.04 µM -0.316060640706185 0.431074832757159 no 1947 0.375978240353336 691 626179 SGTC_1289 0976-0073 69.1 µM -0.31655825121518 0.430934969038085 no 1948 0.375789409192806 712 3391136 SGTC_108 0509-0257 621.132 µM -0.317402229220309 0.430697771386641 no 1949 0.375469207964141 677 536624 SGTC_3034 9090421 49.47 µM -0.318251981841816 0.430458976051871 no 1950 0.375146902520439 699 17173761 SGTC_1321 1326-2144 215 µM -0.320079785250323 0.429945417638452 no 1951 0.374453924617346 713 3513030 SGTC_1104 tacrolimus 29.8 µM -0.320921819603994 0.429708870838292 no 1952 0.37413481908464 683 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3172 9105863 49.47 µM -0.321331213674309 0.429593871746786 no 1953 0.373979702261615 693 2348785 SGTC_1158 4092-0494 91.8 µM -0.32444009776481 0.428720779567222 no 1954 0.372802433224095 702 1148199 SGTC_620 0109-0052 432 µM -0.325148891894929 0.428521772039921 no 1955 0.372534193564278 683 493037 SGTC_1193 1488-0126 41.5 µM -0.325281528769036 0.428484533714308 no 1956 0.372484004652369 661 1384710 SGTC_2595 hexamethylquercetagetin 100 µM -0.325889956675666 0.428313723343867 no 1957 0.372253807334873 730 386331 SGTC_694 1315-0438 43.2 µM -0.327098558744165 0.42797445962805 no 1958 0.371796670933484 716 6793154 SGTC_2610 ononetin 44.17 µM -0.329177831928228 0.427390916678715 no 1959 0.371010638819309 701 259632 SGTC_687 k029-0044 34.9 µM -0.330468944307092 0.427028648983157 no 1960 0.370522827297134 710 5829338 SGTC_1471 k673-0312 37 µM -0.333471958987261 0.426186284462268 no 1961 0.369389026393892 691 24099884 SGTC_2065 5221596 34.26 µM -0.334120692530758 0.426004354707715 no 1962 0.369144243045917 686 788581 SGTC_406 estrone 100 µM -0.334384869084497 0.425930273984974 no 1963 0.369044577838107 711 5870 A steroid. SGTC_714 4296-0578 26.1 µM -0.334762107314565 0.425824492896352 no 1964 0.368902273406133 684 1589775 SGTC_2262 9014885 67.46 µM -0.33619554492573 0.425422592471965 no 1965 0.368361706112562 690 6457424 SGTC_174 3553-0389 74.3 µM -0.338121633001947 0.424882687119192 no 1966 0.367635764423015 673 738071 SGTC_752 1896-0090 130 µM -0.338930046766213 0.424656121058686 no 1967 0.367331214330065 682 772567 SGTC_260 nsc-65238 3.989 µM -0.341845436445533 0.423839261134444 no 1968 0.366233606910296 688 3246252 SGTC_3202 9113761 49.47 µM -0.342542365748633 0.423644037574186 no 1969 0.36597138343711 723 4798415 SGTC_2840 9008771 71.43 µM -0.342839689906374 0.423560756949116 no 1970 0.365859532633001 667 2992978 SGTC_2450 5739737 12.93 µM -0.345836700287283 0.42272148433095 no 1971 0.364732721099365 689 2262825 SGTC_1957 st077035 62.4 µM -0.346721668440046 0.422473727740812 no 1972 0.364400214914807 709 705593 SGTC_844 0330-0132 15.3 µM -0.347145964215623 0.422354952332024 no 1973 0.364240831817751 698 2828079 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.349459001346045 0.421707575781086 no 1974 0.363372372557687 709 5357218 A potent inhibitor of glutathione S-transferases. SGTC_311 1315-0136 58 µM -0.350606178824062 0.421386580267244 no 1975 0.362941910213911 707 6759207 SGTC_1835 st008666 49.2 µM -0.351294298821959 0.421194060192655 no 1976 0.36268378581044 700 690455 SGTC_2732 terfenadine 20 µM -0.352230033204709 0.420932293572972 no 1977 0.362332877564681 711 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1832 st054113 55 µM -0.352925720502913 0.420737701469586 no 1978 0.362072063920664 711 1251267 SGTC_2774 tamoxifen 10.92 µM -0.353085308227937 0.420693065592786 no 1979 0.362012243398 690 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2529 gangaleoidin 93.61 µM -0.3531285491618 0.420680971498566 no 1980 0.361996035367894 692 4565183 SGTC_1678 st019265 80.2 µM -0.359071299681294 0.419019555453047 no 1981 0.359770875685491 733 5367020 SGTC_2353 9059630 146.67 µM -0.359975518013992 0.418766888698621 no 1982 0.359432720896557 702 4779114 SGTC_2260 7964312 200 µM -0.359984439124829 0.418764396029249 no 1983 0.359429385174561 710 231951 SGTC_1245 0418-0076 17.2 µM -0.360621217472766 0.418586480666388 no 1984 0.359191312967029 737 6790114 SGTC_553 k007-0256 45.7 µM -0.3607382299962 0.41855378927073 no 1985 0.359147571458565 706 6287000 SGTC_2505 galangin 7.89 µM -0.362185045589872 0.418149619075164 no 1986 0.358606876965649 712 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3174 9107204 49.47 µM -0.362904270918717 0.417948734486687 no 1987 0.358338198106547 725 3938802 SGTC_1146 3579-1023 7 µM -0.363032346454549 0.417912964351143 no 1988 0.3582903606624 703 X1146 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.36312099254618 0.41788820683782 no 1989 0.358257251797229 713 688667 SGTC_2524 avocatin b 10.57 µM -0.363737783180871 0.417715955551792 no 1990 0.358026913143967 721 6710748 SGTC_1350 1495-0454 146 µM -0.363856613888004 0.417682771480949 no 1991 0.35798254209899 706 1069057 SGTC_2479 5617353 43.85 µM -0.363874564728721 0.417677758669621 no 1992 0.357975839473367 728 2731746 SGTC_2568 diosmetin 100 µM -0.365051817432454 0.417349037533476 no 1993 0.357536363303931 746 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2560 caryophyllene 100 µM -0.36547592781005 0.417230628462554 no 1994 0.357378086352164 694 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_532 1548-0774 215 µM -0.365634474312044 0.417186365158172 no 1995 0.357318923484976 750 5932993 SGTC_1402 3909-7673 35.9 µM -0.366606286801939 0.416915075711208 no 1996 0.356956359039032 684 5328014 SGTC_2998 9066762 71.4286 µM -0.366710083944912 0.416886102221313 no 1997 0.356917641960827 721 4945196 SGTC_2848 9016370 25.97 µM -0.367129831912515 0.416768940177098 no 1998 0.356761087993967 684 7894410 SGTC_1333 1482-0047 286 µM -0.367877795879202 0.416560183255662 no 1999 0.356482178670374 726 3811116 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.367917984564341 0.416548967249668 no 2000 0.356467194826737 707 616764 SGTC_1014 4130-3005 69.3 µM -0.368593670334757 0.416360404561501 no 2001 0.356215307113848 722 743608 SGTC_2984 9022109 38.96 µM -0.369397168326806 0.416136198550477 no 2002 0.355915854160875 727 6459207 SGTC_45 0kpi-0036 14.9 µM -0.370606609816613 0.415798770583857 no 2003 0.355465279105133 729 2795021 SGTC_3161 9100388 49.47 µM -0.370720599246986 0.415766971314817 no 2004 0.355422822969486 700 25236368 SGTC_8 0354-0001 70 µM -0.371480343789368 0.415555041893314 no 2005 0.355139896818104 712 4993152 SGTC_821 1114-0266 29.2 µM -0.37215531536172 0.415366780345884 no 2006 0.354888606786564 707 3123235 SGTC_1361 1608-0041 5.61 µM -0.372648783115492 0.415229155725176 no 2007 0.354704930052986 707 X1361 SGTC_2851 9015922 71.43 µM -0.372810407553534 0.415184082087743 no 2008 0.35464477814572 730 2996893 SGTC_2908 7930301 100 µM -0.373399937685475 0.415019684068243 no 2009 0.354425402935501 721 2223178 SGTC_807 1315-0151 48 µM -0.373491431206454 0.414994171262489 no 2010 0.354391360808479 744 4011080 SGTC_759 3486-0358 89.3 µM -0.374632110500896 0.414676124996987 no 2011 0.353967044345322 751 875103 SGTC_3114 9122766 49.47 µM -0.375128584488481 0.414537714676468 no 2012 0.35378241968315 698 17176985 SGTC_2216 7189485 200 µM -0.375533259452439 0.414424904546725 no 2013 0.353631957918385 703 731273 SGTC_2110 5483698 200 µM -0.376946198788794 0.414031078729659 no 2014 0.353106793874803 688 2848765 YHR062C RPP1 SGTC_3027 9089541 49.47 µM -0.377918319489499 0.413760171596107 no 2015 0.352745636482766 709 9943819 SGTC_1275 0867-0008 21.1 µM -0.378210207550584 0.41367883727657 no 2016 0.352637221581361 717 3422836 SGTC_1762 st045503 25.4615 µM -0.379087556273691 0.413434387230669 no 2017 0.352311423275378 722 4645554 SGTC_225 nsc-122657 1.016 µM -0.380035903968258 0.413170192931403 no 2018 0.351959381769642 731 275685 SGTC_463 ikarugamyin 104 µM -0.380519717175991 0.413035425549585 no 2019 0.351779831584892 724 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_172 1112-0046 2.638 µM -0.380520145432269 0.413035306262263 no 2020 0.351779672667336 737 2802135 YIL048W NEO1 SGTC_2741 miltefosine 3.04 µM -0.381267418021666 0.412827171766469 no 2021 0.351502413846503 720 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.38234695113447 0.412526537515184 no 2022 0.351102016673931 711 279621 SGTC_2820 7989630 71.43 µM -0.382959462853324 0.41235598472515 no 2023 0.350874910464708 692 2984098 SGTC_2948 9070189 9.45 µM -0.384066131308107 0.412047876860493 no 2024 0.350464716644784 722 6473636 YDL196W YDL196W SGTC_456 gingerol 170 µM -0.384126660335296 0.412031026519427 no 2025 0.350442286193135 744 442793 A herb. SGTC_2096 5468907 200 µM -0.384425471889831 0.41194784440086 no 2026 0.350331562201987 699 759785 SGTC_2570 licareol 100 µM -0.387265028586291 0.411157576451138 no 2027 0.349280006330819 726 443158 SGTC_3282 9108498 15.4605 µM -0.388546260158142 0.410801118783843 no 2028 0.348805913535117 733 16459645 SGTC_3213 9129884 49.47 µM -0.389903433444625 0.410423613336543 no 2029 0.348303977465163 730 17190742 SGTC_73 0327-0325 16.231 µM -0.390839809098814 0.410163203491583 no 2030 0.347957823670207 717 53298 SGTC_2294 7971431 200 µM -0.39177161998347 0.409904102448159 no 2031 0.347613483086782 761 5741572 SGTC_911 3456-4043 236 µM -0.392428587885553 0.409721448384355 no 2032 0.347370783267568 701 914281 SGTC_112 phenothiazine 287.218 µM -0.392964650273524 0.409572423692301 no 2033 0.34717279521484 748 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3173 9105693 49.47 µM -0.393689337027957 0.409370982427869 no 2034 0.346905207375187 763 17096658 SGTC_1931 st074438 57.1 µM -0.394270905798113 0.409209340989766 no 2035 0.346690520512209 756 2787313 SGTC_3039 9090270 49.47 µM -0.394764100552444 0.409072274352806 no 2036 0.346508495599027 700 17173750 SGTC_2208 7283366 200 µM -0.396326630324062 0.408638096052667 no 2037 0.345932042058167 709 898663 SGTC_209 4077-0173 175.592 µM -0.39769082270902 0.408259121170382 no 2038 0.345429051544628 707 15993494 SGTC_1587 estradiol valerate 56.1 µM -0.398435721027532 0.408052223385554 no 2039 0.345154515657987 738 13791 A steroid. SGTC_3077 9117319 49.47 µM -0.398839779210329 0.407940005710452 no 2040 0.345005632128709 738 17154678 SGTC_2782 7736369 71.43 µM -0.399430655085307 0.407775917404969 no 2041 0.344787954986994 712 2950836 YOL077C BRX1 SGTC_1947 st076332 61.6 µM -0.399441474719294 0.407772912905345 no 2042 0.34478396954059 726 24208416 SGTC_2593 nobiletin 86.24 µM -0.399602793048296 0.407728117129644 no 2043 0.344724549466922 702 72344 An anti-infammatory. SGTC_2458 5808907 16.39 µM -0.399923842242374 0.407638969984048 no 2044 0.344606305444933 739 2731747 SGTC_2443 5493264 126.67 µM -0.400246426615733 0.407549401375241 no 2045 0.344487511298817 737 5340055 SGTC_1502 4534-4282 27.7 µM -0.402204060509183 0.40700594958756 no 2046 0.343766927070974 741 3278949 SGTC_2894 9048625 32.47 µM -0.402205051294467 0.407005674584411 no 2047 0.343766562516839 741 4092861 SGTC_779 1360-0071 233 µM -0.402618960643468 0.406890793589104 no 2048 0.34361427950104 729 7566 SGTC_758 0868-0029 16 µM -0.402658357876528 0.406879859261111 no 2049 0.343599786032408 687 762687 SGTC_1072 oxiconazole 14.9 nM -0.40343186719636 0.406665193806396 no 2050 0.343315273733256 708 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_421 streptovitacin 30 mM -0.403784561099097 0.406567322975565 no 2051 0.34318557527336 733 91467 include heat shock SGTC_906 1165-0455 526 µM -0.406441796387182 0.405830141229074 no 2052 0.342209007284484 749 3252859 SGTC_2264 7948757 110.76 µM -0.406974812653956 0.405682309654759 no 2053 0.342013243729788 713 2971411 SGTC_1778 st046819 58.9 µM -0.407859090011456 0.405437085815419 no 2054 0.341688564431788 728 671715 SGTC_2367 9070478 135.38 µM -0.408632327386953 0.405222685498741 no 2055 0.341404751522324 701 572802 SGTC_2655 perillic acid 100 µM -0.409358658999408 0.405021316936193 no 2056 0.341138236804411 726 5702197 An apoptosis inducer. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.409535266039586 0.404972358104756 no 2057 0.341073445901221 763 6708760 SGTC_325 2810-4341 181 µM -0.409990900365109 0.404846054471696 no 2058 0.340906311357762 705 774970 SGTC_2245 6637752 200 µM -0.41203285208803 0.404280139330061 no 2059 0.340157672053634 703 681890 SGTC_1205 4161-2785 76 µM -0.412061262673136 0.404272266909906 no 2060 0.340147260335987 747 3498106 SGTC_923 1900-2434 73.3 µM -0.412607385933279 0.404120946632833 no 2061 0.339947144503682 765 5910570 SGTC_1234 0326-0494 15.5 µM -0.413660754719365 0.403829118889587 no 2062 0.339561286196033 749 1547813 SGTC_60 0986-0278 202 µM -0.416093472234185 0.403155357960111 no 2063 0.338670803221682 778 3110598 SGTC_929 2805-0021 398 µM -0.416349930391996 0.403084346496513 no 2064 0.338576980530589 761 3098024 SGTC_2356 9061756 188.97 µM -0.418266616693087 0.402553730873034 no 2065 0.337876097276004 694 20104043 SGTC_748 act1.228 77.9 µM -0.41923077358019 0.402286881369916 no 2066 0.33752374191053 716 4421505 YNR035C ARC35 SGTC_1811 st050069 61.5 µM -0.420017282666039 0.40206923312623 no 2067 0.337236414158373 732 3877702 SGTC_3036 9090181 49.47 µM -0.421153868424046 0.401754762898897 no 2068 0.336821363987021 711 25236586 SGTC_1942 st076330 65.2 µM -0.423139981437582 0.401205398501137 no 2069 0.336096566660098 760 24208414 SGTC_3189 9110682 49.47 µM -0.423206110587809 0.401187110346741 no 2070 0.336072444440162 745 17122418 SGTC_1529 apigenin 74 µM -0.424132106795474 0.400931046922707 no 2071 0.335734735696151 765 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3165 9101544 49.47 µM -0.424166706041607 0.400921480103459 no 2072 0.335722119997021 734 5002184 SGTC_1141 3253-0389 52.6 µM -0.425129043852858 0.400655413975628 no 2073 0.335371303224876 759 5402031 SGTC_2916 7875993 68.79 µM -0.425578772751094 0.4005310892044 no 2074 0.335207405363209 777 1299250 SGTC_1563 conessine 56.1 µM -0.42585883341603 0.40045367325698 no 2075 0.3351053567342 745 441082 An anti-amoebic, histamine inhibitor. SGTC_1228 0124-0032 52.5 µM -0.427778356298069 0.399923173329534 no 2076 0.334406248046803 717 X1228 SGTC_2553 4-methylesculetin 85.09 µM -0.428688858514878 0.399671601678423 no 2077 0.334074834904471 737 5319502 SGTC_3061 glucosamine 200 µM -0.429268314427192 0.399511519758772 no 2078 0.333863986434729 731 91431 and experimental redox chemotherapeutic SGTC_2884 9058502 51.95 µM -0.43104797547871 0.399019971926619 no 2079 0.333216743599462 740 6471554 SGTC_164 4100-3994 89.624 µM -0.43190960421736 0.398782044898594 no 2080 0.332903557071556 763 4615967 SGTC_636 0kpi-0074 126 µM -0.432692913360006 0.398565777392903 no 2081 0.332618939423692 724 616434 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.433928247457264 0.398224771507236 no 2082 0.332170273250272 723 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2634 4'-methoxyflavone 100 µM -0.435657833221532 0.397747461312756 no 2083 0.331542501849963 734 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1711 st032263 62.8 µM -0.438059739188996 0.397084866253678 no 2084 0.330671489350877 734 3958979 SGTC_1784 st039334 36.3 µM -0.439782604429878 0.396609775631681 no 2085 0.330047283944572 746 3496984 SGTC_2707 st078556 66.6 µM -0.440025445658645 0.396542823001114 no 2086 0.329959338951578 746 17250899 SGTC_1066 ketoconazole 628 nM -0.440464017506755 0.396421914118339 no 2087 0.329800533894065 758 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1464 k208-0027 110 µM -0.440864771660112 0.396311439819243 no 2088 0.329655449287984 763 X1464 SGTC_705 1124-0212 310 µM -0.441130710494696 0.396238134116128 no 2089 0.329559185877057 763 9554485 SGTC_2265 7929201 200 µM -0.441911922993806 0.396022815105409 no 2090 0.329276471220431 765 1265108 SGTC_2805 7950783 58.44 µM -0.441914947039813 0.396021981674708 no 2091 0.329275377031489 721 1178958 YDL195W SEC31 SGTC_2312 7706453 155.7 µM -0.442596888377664 0.395834049971091 no 2092 0.329028667923511 733 976098 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.444995070055739 0.395173343507292 no 2093 0.328161658423704 757 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2847 9005661 71.43 µM -0.445919377791198 0.394918774196997 no 2094 0.327827742100481 735 2991449 SGTC_1116 jasmonic acid  1.58368 µM -0.447545452708733 0.394471035769368 no 2095 0.327240638781058 765 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_376 3970-0862 59.1 µM -0.44980518159044 0.393849052777195 no 2096 0.326425460655787 755 3135186 SGTC_1100 amiodarone 5.07 µM -0.450331700262138 0.393704169058383 no 2097 0.326235642326788 723 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2172 5754775 163.918 µM -0.45250332945078 0.393106751059101 no 2098 0.325453211618334 727 2263357 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.453193137033053 0.392917036698145 no 2099 0.325204836945837 722 5106787 A p450 inhibitor. SGTC_2199 6590217 200 µM -0.453687904593025 0.392780978888371 no 2100 0.325026736911658 710 703109 SGTC_2318 6029776 164 µM -0.455263759740332 0.392347716518845 no 2101 0.324459747517553 778 818325 SGTC_593 1203-0218 61.7 µM -0.457320176768841 0.39178253015676 no 2102 0.323720464672475 760 3666956 SGTC_303 1348-1668 34.2 µM -0.459445883721232 0.39119854010763 no 2103 0.322957002539821 751 5380509 SGTC_889 0919-1524 82.7 µM -0.46060660989931 0.390879760180753 no 2104 0.322540434232022 742 3905452 SGTC_917 harmaline 728.087 nM -0.46156813715867 0.39061574342546 no 2105 0.322195524212876 722 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1233 0325-0408 14.2 µM -0.463344617230915 0.390128089138465 no 2106 0.321558684745042 757 12874 SGTC_2007 4011539 71.82 µM -0.463964445509486 0.389957983245862 no 2107 0.321336609523195 751 45595301 SGTC_54 0159-0055 9 µM -0.464832260416515 0.389719855226006 no 2108 0.321025791695276 787 3319099 SGTC_1268 0828-0275 2.46 µM -0.467225335839192 0.389063411105131 no 2109 0.320169334393006 747 745337 SGTC_1742 st038235 28.8875 µM -0.468235388349 0.388786438656442 no 2110 0.319808133900103 770 564103 YBR002C RER2 SGTC_773 4358-1457 44.6 µM -0.468344908136131 0.388756409984507 no 2111 0.319768979262518 782 1186886 SGTC_2826 7992541 19.48 µM -0.468652209807764 0.388672156055774 no 2112 0.31965912595336 795 2985066 SGTC_1851 st056236 18.9 µM -0.469734602615201 0.388375434525375 no 2113 0.319272321361726 752 5393171 SGTC_2401 5128683 200 µM -0.470524049005405 0.388159060867134 no 2114 0.318990328267244 783 708373 SGTC_1134 3477-0009 42.5 µM -0.471307771813957 0.387944290277793 no 2115 0.318710483248106 762 3973534 SGTC_2338 7999974 200 µM -0.471594875227521 0.387865621328348 no 2116 0.318607992681035 762 315925 SGTC_2515 chrysin 20.77 µM -0.471842849030095 0.38779767795258 no 2117 0.31851948182353 731 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1182 1222-0449 220 µM -0.472296087245831 0.387673502203433 no 2118 0.318357731405372 742 658318 SGTC_2986 9022445 71.43 µM -0.475102223179019 0.386904948498757 no 2119 0.317357056986295 783 6459286 SGTC_1456 k015-0012 13 µM -0.475402621813443 0.386822700548416 no 2120 0.317250013046189 750 2989616 SGTC_1917 st066507 28.5 µM -0.478854254796637 0.385878022757922 no 2121 0.316021158149323 734 3156428 SGTC_1974 st069448 26.9 µM -0.479453780281293 0.385714007352983 no 2122 0.315807920844562 744 6323587 YNR016C ACC1 SGTC_1761 st044296 37 µM -0.481689029874388 0.385102678434098 no 2123 0.315013435098874 746 1826700 SGTC_891 0929-0073 133 µM -0.481830758467553 0.385063926022784 no 2124 0.314963088599984 778 5603632 SGTC_1923 st058458 19.1 µM -0.482348416722442 0.384922394081524 no 2125 0.31477922915901 785 3534982 SGTC_1530 rhein 70.4 µM -0.482916771542636 0.384767018948283 no 2126 0.314577416415903 739 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_251 melphalan 456.522 µM -0.483223423074574 0.384683195157771 no 2127 0.314468552880169 751 460612 A DNA alkylator. SGTC_341 1486-1430 230 µM -0.484391652026389 0.384363906926904 no 2128 0.314053970906125 765 2054753 YPL210C SRP72 SGTC_3083 9117465 49.47 µM -0.487864953522995 0.383415084229275 no 2129 0.312822749978534 782 16420915 SGTC_3050 9093513 49.47 µM -0.488917332177114 0.383127737288608 no 2130 0.31245011223776 765 25236664 SGTC_803 4488-1585 147 µM -0.49065163697313 0.38265433403758 no 2131 0.311836429016323 758 747204 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.491554185002924 0.382408039967568 no 2132 0.311517269089919 763 1377 SGTC_2285 7945142 200 µM -0.495321649380695 0.381380460753935 no 2133 0.310186545659956 785 2970608 SGTC_940 3232-1287 54.8 µM -0.495791209879861 0.381252446134364 no 2134 0.310020863621356 780 1585493 YIL048W NEO1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.499205904617265 0.380321901573794 no 2135 0.308817167656343 755 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2425 5628681 7.85 µM -0.501871281837057 0.379596035570454 no 2136 0.30787903376909 772 5714958 SGTC_766 1391-0721 126 µM -0.502524284580021 0.37941826697982 no 2137 0.307649387198696 779 1020919 YIL115C NUP159 SGTC_2933 9026794 32.47 µM -0.503143203742574 0.379249800576329 no 2138 0.307431796615503 763 17586027 SGTC_3262 9137218 49.47 µM -0.503203990992987 0.37923325585599 no 2139 0.307410429572209 742 17650664 SGTC_291 SEC14.278 35.5 µM -0.503207224761453 0.379232375713889 no 2140 0.307409292903624 753 1068044 SGTC_1721 st082152 9.2685 µM -0.503756598334576 0.379082860552201 no 2141 0.307216215124002 744 5296051 SGTC_1757 st041620 31.8375 µM -0.504801633982102 0.378798498067061 no 2142 0.306849084027426 763 5289815 SGTC_47 0149-0135 24.25 µM -0.505956745606657 0.37848425936411 no 2143 0.306443507481255 739 5239155 SGTC_1878 temozolomide 1 mM -0.507892609148248 0.377957803697833 no 2144 0.305764329091598 772 5394 DNA alkylating agent. SGTC_420 mitomycin C 81.9 mM -0.510260087330328 0.377314279005611 no 2145 0.30493463046113 743 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_119 0121-0043 24.815 µM -0.510413651245283 0.377272549212865 no 2146 0.304880847512852 782 1092378 SGTC_1349 flufenamic acid 69 µM -0.510444850148013 0.37726407133021 no 2147 0.304869921183842 761 3371 A non-steroidal anti-inflammatory. SGTC_1802 st050112 57.9 µM -0.510600949717339 0.37722165425795 no 2148 0.304815255360142 751 4662563 SGTC_2242 6630449 61.2675 µM -0.510816159439024 0.377163177561393 no 2149 0.304739896398322 750 691249 YDR170C SEC7 SGTC_2879 9041815 71.43 µM -0.51250636365844 0.376704014003812 no 2150 0.304148333865938 765 4942971 SGTC_501 nsc-95397 161 µM -0.513189659983362 0.376518438096705 no 2151 0.30390932909013 774 262093 SGTC_1338 1486-1223 76 µM -0.514004225879155 0.376297248078371 no 2152 0.303624518072387 755 3444526 SGTC_1882 5615643 20 µM -0.515417370303008 0.375913614391443 no 2153 0.303130698411773 758 2253075 SGTC_2313 7726885 200 µM -0.51570472736332 0.375835619060425 no 2154 0.303030326197186 750 726423 SGTC_2816 7982706 58.44 µM -0.516226441648507 0.375694026742731 no 2155 0.302848132333014 776 2981853 SGTC_1109 tnp00067 928.257 nM -0.517913483330322 0.375236281332852 no 2156 0.30225931706562 777 676295 SGTC_1956 st077085 54 µM -0.518438690596542 0.375093812543716 no 2157 0.302076112896842 779 24208685 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.519173416132027 0.374894537998876 no 2158 0.301819907719307 781 364106 SGTC_1619 st003326 88.7 µM -0.519326860967089 0.374852924427368 no 2159 0.301766412503025 723 2849032 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.519538879560399 0.374795428305108 no 2160 0.301692503829668 772 5282362 SGTC_149 3970-0822 46.1 µM -0.51988706521783 0.374701011845846 no 2161 0.30157114562856 748 3114250 YBL034C STU1 SGTC_163 TUB2.036 7.546 µM -0.52068416280256 0.37448489357394 no 2162 0.301293404358036 777 15992207 YJR013W GPI14 SGTC_52 0329-0193 875 nM -0.521740265253131 0.374198611654965 no 2163 0.300925592767777 791 3739292 SGTC_1993 st073995 70.8 µM -0.522185565708952 0.374077923056405 no 2164 0.300770567510446 767 3098394 SGTC_1436 4092-1007 8.32 µM -0.522331075043297 0.37403848872314 no 2165 0.300719918239953 732 2881121 SGTC_2569 tetrandrine 100 µM -0.524294952295786 0.373506389500244 no 2166 0.300036703591496 745 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_250 brefeldin a 552.239 µM -0.528369696264083 0.372403135270003 no 2167 0.298621383068172 763 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1491 4138-0063 26.5 µM -0.529190380218765 0.372181057900835 no 2168 0.298336694634858 771 23883227 SGTC_2955 9076254 12.21 µM -0.529383293583325 0.372128861643338 no 2169 0.298269792532792 770 16459619 SGTC_2607 solasodine 47.35 µM -0.530675408000333 0.371779316944636 no 2170 0.297821865162719 759 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3157 9099274 49.47 µM -0.533399352240239 0.371042778038152 no 2171 0.296878582906312 775 17217662 SGTC_2844 9010103 25.97 µM -0.533570798778615 0.370996435643421 no 2172 0.296819257966282 805 2480525 SGTC_2304 7443016 91.4 µM -0.534954970965069 0.370622359287957 no 2173 0.296340497436157 785 939854 SGTC_1459 k035-0031 35.7 µM -0.535602223901524 0.37044747933076 no 2174 0.296116745721288 767 3877128 YMR208W ERG12 SGTC_953 1188-0045 9.7 µM -0.539977378284184 0.369266068975389 no 2175 0.294606316638178 771 6144426 SGTC_432 NS 1619 61.3 µM -0.542034576797768 0.368710995279973 no 2176 0.293897343244302 754 4552 A K+/calcium channel activator. SGTC_3078 9116413 49.47 µM -0.545941754255609 0.367657514538423 no 2177 0.292552987776162 765 17177322 SGTC_416 estradiol valerate 100 µM -0.547028623802854 0.367364641651682 no 2178 0.292179533614881 780 13791 A steroid. SGTC_2557 derrustone 83.84 µM -0.548635931138693 0.366931670625677 no 2179 0.291627661201171 810 629853 An antioxidant. SGTC_289 k017-0060 526 µM -0.549868230196304 0.366599832629029 no 2180 0.291204878070233 784 5512909 SGTC_1864 st057645 30.4 µM -0.550312968554243 0.366480096326189 no 2181 0.291052365384633 796 688666 SGTC_1194 1488-0194 225 µM -0.551446532371853 0.366174967278775 no 2182 0.290663804859506 775 1391452 SGTC_1236 0330-0013 258 µM -0.553005224833954 0.365755541651482 no 2183 0.290129916224036 782 4617066 SGTC_3273 9137859 49.47 µM -0.554092272837025 0.365463124866149 no 2184 0.289757849065684 805 2377234 SGTC_2681 menadione 3.18 µM -0.554927459300067 0.365238512135288 no 2185 0.289472139480116 786 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2836 9010338 19.48 µM -0.559429789458095 0.364028465882973 no 2186 0.287934217794282 748 2994051 SGTC_3241 9133421 49.47 µM -0.559834803178359 0.363919680620054 no 2187 0.287796061135165 800 17018221 SGTC_639 0833-0042 114 µM -0.561382987803085 0.363503944816121 no 2188 0.287268239431029 790 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1669 st015249 58.4 µM -0.561584554960189 0.363449829567596 no 2189 0.287199552972843 796 722793 SGTC_300 r073-0011 5.04 µM -0.562180991332553 0.363289718738005 no 2190 0.286996355577215 794 2735780 SGTC_881 0833-0569 170 µM -0.56274386913496 0.363138638469697 no 2191 0.286804653588825 752 5418700 SGTC_2263 7948595 193.29 µM -0.565649401477112 0.36235911273554 no 2192 0.285816069003647 757 2971371 SGTC_974 1326-0144 138 µM -0.570005336262792 0.361191527601552 no 2193 0.284337039392622 784 5411856 SGTC_3242 9133940 49.47 µM -0.570336922306725 0.36110270050887 no 2194 0.284224601473344 800 17248444 SGTC_2872 9044037 25.97 µM -0.570665504297326 0.361014685546388 no 2195 0.284113203175887 783 6465195 SGTC_869 0564-0080 44.1 µM -0.570852134488898 0.360964697497155 no 2196 0.284049939727702 764 6843321 SGTC_1545 lovastatin 49.4 µM -0.571370694086305 0.360825816132235 no 2197 0.283874195040928 774 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3325 9138760 55.175 µM -0.571958471980462 0.360668418813701 no 2198 0.283675054580932 771 43844959 SGTC_2093 5331342 194.4 µM -0.572224253299589 0.360597254665059 no 2199 0.283585029251998 782 33839 SGTC_1258 0671-0043 57.1 µM -0.573267191698468 0.360318049859933 no 2200 0.283231897932805 811 4298767 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.577594135979502 0.359160481513248 no 2201 0.281769083454844 784 2724278 An inhibitor of dopamine biosynthesis. SGTC_2571 chrysanthemic acid 100 µM -0.578206610251165 0.358996733091275 no 2202 0.281562318229638 823 2743 An insecticide. SGTC_679 0422-0091 41.4 µM -0.579956695472598 0.358528980873971 no 2203 0.280971910500047 812 627384 YHR062C RPP1 SGTC_3044 9093193 49.47 µM -0.580284356631227 0.358441429134747 no 2204 0.280861437453019 805 25236277 SGTC_469 w7 172 µM -0.582480244055186 0.357854875695748 no 2205 0.280121622433449 782 45115570 A P450 inhibitor. SGTC_2045 5106652 78.05 µM -0.582489013285424 0.357852533978526 no 2206 0.280118669891946 784 673349 SGTC_1184 1269-1718 139 µM -0.586181459549041 0.35686698705898 no 2207 0.278876789792093 783 5403821 SGTC_190 3970-0790 3.722 µM -0.586245808504377 0.356849820191416 no 2208 0.278855171086186 790 2832352 SGTC_148 3253-0744 288.01 µM -0.587295804251825 0.356569745699904 no 2209 0.278502529275856 773 6893655 SGTC_1881 5652484 16 µM -0.587452475466171 0.356527962051165 no 2210 0.278449929770838 803 2255129 SGTC_561 1550-0330 72.9 µM -0.588656139053521 0.356207006772129 no 2211 0.278045983180339 789 6812934 SGTC_2383 9036125 200 µM -0.588768891779865 0.356176946622656 no 2212 0.278008158288049 787 79580 SGTC_1935 st074532 41.6 µM -0.588974185931848 0.356122217000719 no 2213 0.277939295189177 799 2829742 SGTC_2958 9077254 16.72 µM -0.59115522957081 0.355540953104931 no 2214 0.277208208580372 781 16457351 SGTC_2699 st077704 54.6 µM -0.591572593703451 0.355429760784259 no 2215 0.277068415282949 792 645852 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.59417605956089 0.354736434935325 no 2216 0.276197181665433 784 5377381 SGTC_146 3448-8650 53.125 µM -0.594457940867493 0.354661396277365 no 2217 0.276102932572705 822 2891488 YIL048W NEO1 SGTC_3079 9117512 49.47 µM -0.595181661778372 0.354468762843594 no 2218 0.275861023483647 836 7185044 SGTC_1267 0828-0272 9.49 µM -0.598825677619473 0.353499398333693 no 2219 0.274644568659712 797 745334 SGTC_189 3970-0742 2.116 µM -0.599640491552774 0.353282774897668 no 2220 0.274372927728401 803 2891807 SGTC_2379 9035213 200 µM -0.599660834488838 0.353277367207296 no 2221 0.27436614754103 791 646551 SGTC_118 0083-0097 135.343 µM -0.600547325843094 0.35304174314873 no 2222 0.274070765265968 818 5207356 SGTC_347 4534-1311 26.2 µM -0.601754362629144 0.352721010637483 no 2223 0.273668828829791 808 2862016 SGTC_672 1441-0018 53.7 µM -0.603688733656367 0.352207229978622 no 2224 0.273025302953953 777 251141 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.603999326123478 0.352124759836628 no 2225 0.272922045097991 789 803109 SGTC_2138 5575593 77.673 µM -0.604287374892948 0.352048281830907 no 2226 0.272826299306418 812 762213 SGTC_3246 9135460 32.98 µM -0.604293307572717 0.352046706745534 no 2227 0.272824327492145 801 41446951 SGTC_1519 esterone 74 µM -0.606675284569122 0.351414513734903 no 2228 0.272033213717991 794 698 A steroid. SGTC_2649 anisomycin 9.56 µM -0.607911455472611 0.351086587319777 no 2229 0.271623100727678 803 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_485 niflumic acid 177 µM -0.608811942594062 0.350847779515067 no 2230 0.271324548367017 798 4488 A COX2 inhibitor. SGTC_1196 1588-0294 184 µM -0.610716321470669 0.350342935282288 no 2231 0.270693699444187 817 6144269 SGTC_2745 rifampicin 24.3 µM -0.610722862512394 0.350341201729765 no 2232 0.270691533906479 783 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3022 9087993 49.47 µM -0.61078252844885 0.350325388790848 no 2233 0.270671780749648 800 17173644 SGTC_938 3126-1755 342 µM -0.610916587439116 0.35028986081147 no 2234 0.270627401464757 789 1777771 SGTC_1564 D-Arginine 115 µM -0.611149631204633 0.350228103251832 no 2235 0.270550262617759 830 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3228 9131799 49.47 µM -0.613029916706132 0.349729964834806 no 2236 0.269928279260366 805 17015818 SGTC_663 1486-0733 13.9 µM -0.613260110457873 0.349668998041966 no 2237 0.269852182216802 814 722445 YPR165W RHO1 SGTC_1031 k035-0009 16 µM -0.614446201433515 0.349354923442429 no 2238 0.269460256679333 810 5180959 SGTC_3093 9117344 49.47 µM -0.614663674517112 0.349297348170853 no 2239 0.269388427005952 782 24824913 SGTC_791 1348-1292 225 µM -0.614948032128106 0.349222070676077 no 2240 0.269294520376422 809 5437054 SGTC_627 1391-0720 175 µM -0.616691146035887 0.348760748891466 no 2241 0.268719231159664 830 997839 SGTC_2596 sinensetin 100 µM -0.616727612141888 0.348751100381143 no 2242 0.268707202652084 801 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_318 1488-0629 67.2 µM -0.619341181836296 0.348059835119461 no 2243 0.267845810124509 824 3662576 SGTC_952 1185-0122 232 µM -0.619782637162715 0.347943123976363 no 2244 0.267700450649713 800 678600 SGTC_983 1491-0821 12.2 µM -0.620577839905795 0.347732926093545 no 2245 0.267438711920012 788 46495113 SGTC_1107 amlodipine 47 µM -0.622567627349719 0.347207165888093 no 2246 0.266784345065453 784 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1927 st060202 13.8 µM -0.622880080101544 0.347124633381625 no 2247 0.266681664565103 808 688887 SGTC_1962 st076595 64.5 µM -0.62320172191945 0.34703968121215 no 2248 0.266575985158872 809 279619 SGTC_2354 9060492 162 µM -0.623819673893323 0.346876489056192 no 2249 0.2663730088222 813 6471895 SGTC_2437 5741531 144.16 µM -0.625118689396885 0.346533530529816 no 2250 0.265946581265962 825 2262990 SGTC_402 epigallocatechin gallate 10 µM -0.62548997002168 0.346435530272285 no 2251 0.265824764635059 816 65064 An antioxidant. SGTC_2330 7979373 200 µM -0.626759056630558 0.34610062999092 no 2252 0.265408592821652 802 1863007 SGTC_2215 7188065 200 µM -0.626990604041524 0.346039539731634 no 2253 0.265332697117005 816 940217 SGTC_2122 5258151 111.688 µM -0.628898334618315 0.345536366692765 no 2254 0.264707808212233 804 2173356 SGTC_2329 6138490 200 µM -0.631366015004852 0.344885908961172 no 2255 0.263900615929412 809 720019 SGTC_2995 9067767 71.4286 µM -0.632641306627291 0.344549933326901 no 2256 0.263483953126999 801 11673567 SGTC_2742 clothiapine 36.27 µM -0.634577160370304 0.34404016692791 no 2257 0.262852114034051 798 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1160 4092-0570 10.5 µM -0.636065645834705 0.343648398174715 no 2258 0.262366817951449 819 4994975 SGTC_3223 9129970 49.47 µM -0.636924851808262 0.343422331908913 no 2259 0.262086897062492 822 17248386 SGTC_134 0269-0018 6.916 µM -0.63740407001303 0.343296268805705 no 2260 0.261930838986186 805 4378915 SGTC_1421 4029-0249 71.4 µM -0.639579467193787 0.342724228371429 no 2261 0.261223017432291 819 2894095 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.639661335487956 0.342702707390054 no 2262 0.261196398675094 820 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1656 st012921 11 µM -0.640333077919331 0.3425261435848 no 2263 0.260978040171533 806 6732821 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.643210723270493 0.341770160111538 no 2264 0.260043688088279 801 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1440 4100-1550 40 µM -0.64346813128877 0.341702567550042 no 2265 0.259960193559881 817 742806 SGTC_2748 diazoxide 86.69 µM -0.646343054954566 0.340947989003684 no 2266 0.259028605188538 768 3019 A potassium channel activatior. SGTC_3337 9144342 33.5465 µM -0.646752104361603 0.340840677784491 no 2267 0.258896197524845 796 17682949 SGTC_368 fentichlor 4.58 µM -0.647666934542994 0.340600725172292 no 2268 0.258600197416771 832 7329 A pesticide. SGTC_429 1112-0049 25.5 µM -0.649874673760457 0.340021918695971 no 2269 0.257886589365783 801 2836170 SGTC_1546 5-methoxyflavanone 78.7 µM -0.651934680744987 0.339482183224405 no 2270 0.257221655511954 806 147795 SGTC_2143 5623677 140.463 µM -0.653596675812023 0.33904696928961 no 2271 0.256685843222926 800 5375313 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.654706948517474 0.33875635025224 no 2272 0.256328225327405 804 6708739 YPR165W RHO1 SGTC_1738 st035555 74 µM -0.655158457710422 0.338638193062199 no 2273 0.256182868910687 825 5331140 SGTC_3133 9127736 49.47 µM -0.657207309911268 0.338102220667666 no 2274 0.255523812987225 803 27243420 SGTC_1238 0333-0287 48.8 µM -0.658282191277351 0.337821166646967 no 2275 0.255178409611738 816 7226 SGTC_1034 k072-0165 12.7 µM -0.659676114350863 0.337456826015834 no 2276 0.254730848959224 829 5835461 SGTC_102 gallobenzophenone 83.616 µM -0.660419142119328 0.337262677226293 no 2277 0.254492445740729 810 70837 SGTC_151 3013-0144 2.285 µM -0.660727761587561 0.337182049505369 no 2278 0.254393458412376 827 906558 YHR107C CDC12 SGTC_276 colchicine 750 µM -0.661281652285284 0.337037362728336 no 2279 0.254215852837691 832 2833 A microtubule depolymerizer. SGTC_1469 k284-2957 126 µM -0.663808759332547 0.336377540500117 no 2280 0.25340635936433 808 23884841 SGTC_537 1334-0398 209 µM -0.664597990572185 0.336171577021604 no 2281 0.253153827421255 829 5846986 SGTC_1865 st057639 52.2 µM -0.66730379081281 0.335465825441074 no 2282 0.252289052741023 832 688818 SGTC_3272 9137413 49.47 µM -0.668763549937702 0.335085318462083 no 2283 0.251823160836164 834 17614870 SGTC_199 4063-0024 41.6 µM -0.668787577102852 0.335079056853997 no 2284 0.251815496206768 810 306215 SGTC_882 0843-0131 351 µM -0.669699495059373 0.334841440039612 no 2285 0.25152468682169 822 5425421 SGTC_375 3970-0961 9.27 µM -0.669997157913236 0.334763892874224 no 2286 0.251429800974775 815 2898222 SGTC_3116 9124943 49.47 µM -0.670561437111654 0.334616906126163 no 2287 0.25124997789942 800 41905195 YPL160W CDC60 SGTC_1049 3226-0134 66 µM -0.671868514284548 0.334276528382976 no 2288 0.25083370318497 819 5702385 SGTC_41 0478-0632 82.643 µM -0.672301133370028 0.334163899450235 no 2289 0.250696004192627 847 3750424 SGTC_2521 angolensin 13.4 µM -0.672541087232262 0.334101435810502 no 2290 0.250619646173685 837 821428 A flavenoid. SGTC_193 1273-0060 1.558 µM -0.673402496354751 0.333877235781035 no 2291 0.25034563044835 829 2847393 YHR072W ERG7 SGTC_599 1935-0052 86.5 µM -0.674386562656488 0.333621184166826 no 2292 0.250032791723739 806 9557311 SGTC_622 1348-1566 26.3 µM -0.67960536972599 0.332264560884123 no 2293 0.248377184361099 824 7340407 SGTC_1414 3917-0015 5.4 µM -0.680047444383301 0.332149744649066 no 2294 0.248237210140608 830 6618702 SGTC_2254 7938975 95.19 µM -0.680196194505142 0.332111114605821 no 2295 0.248190120808296 839 2969277 SGTC_2022 5136654 200 µM -0.680647541133959 0.33199391191002 no 2296 0.248047268665949 840 1713771 SGTC_3069 9117009 49.47 µM -0.680791754343003 0.331956467045655 no 2297 0.248001634135811 810 41904981 SGTC_39 0986-0283 58.349 µM -0.681939843336284 0.33165842638769 no 2298 0.247638495072432 798 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_195 4234-0266 16.654 µM -0.682174165864022 0.331597610006323 no 2299 0.247564414073347 834 2303354 SGTC_3009 9080819 71.4286 µM -0.683368158035726 0.331287788650981 no 2300 0.247187117727144 827 17027216 SGTC_503 tyrphostin 8 294 µM -0.684372894672013 0.331027165431162 no 2301 0.246869863722755 850 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1373 2887-0003 58.5 µM -0.686190656044705 0.330555856088199 no 2302 0.246296444632528 840 776948 SGTC_1061 3448-9325 110 µM -0.687989360828182 0.330089752084763 no 2303 0.24572974060172 839 723482 SGTC_2818 7996756 12.99 µM -0.692885299928162 0.3288223889844 no 2304 0.244190767776981 861 2241621 SGTC_2704 st078022 71.1 µM -0.69328728095844 0.32871841928588 no 2305 0.244064641694727 838 54697681 SGTC_3158 9100007 49.47 µM -0.693817780044487 0.328581229545019 no 2306 0.243898245420169 835 19297233 SGTC_3280 9140961 49.47 µM -0.693833464993666 0.328577173689552 no 2307 0.243893326612925 851 4901226 SGTC_265 mycophenolic acid 32.932 µM -0.695202514259009 0.328223239183271 no 2308 0.243464198451701 843 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_12 0849-0099 9.267 µM -0.69855236417876 0.327357867209027 no 2309 0.242415911152894 836 6071388 SGTC_1291 0993-0025 5.79 µM -0.699007314167733 0.327240410660068 no 2310 0.242273729948819 832 4353356 SGTC_298 1391-0729 10 µM -0.69902032507114 0.327237051826314 no 2311 0.24226966443947 837 3237558 SGTC_3182 9108849 49.47 µM -0.699484004934098 0.327117359544137 no 2312 0.242124802806613 817 17133045 SGTC_2951 9072950 58.06 µM -0.699618956088559 0.327082527185775 no 2313 0.242082650549877 843 16488155 SGTC_910 3454-3003 490 µM -0.701781995251683 0.326524429012448 no 2314 0.241407564394057 843 820824 SGTC_3353 9151644 39.2805 µM -0.706204128197936 0.325384657720077 no 2315 0.240030601755269 833 4909158 SGTC_2125 5246583 200 µM -0.70670979739616 0.32525442904627 no 2316 0.239873419901647 837 835267 SGTC_1486 3970-0793 4.53 µM -0.707760768325236 0.324983833119955 no 2317 0.239546916528017 852 2844330 SGTC_878 0828-0289 13.7 µM -0.710920604016935 0.324170819269273 no 2318 0.238566718653062 839 745350 YLR208W SEC13 SGTC_2360 9040895 200 µM -0.710925516732881 0.324169555897198 no 2319 0.238565196413566 834 4914414 SGTC_2625 euphol 100 µM -0.711423645314521 0.324041465834426 no 2320 0.238410875381084 831 6708538 A triterpene alcohol. SGTC_3218 9131285 49.47 µM -0.71195391981668 0.323905132575516 no 2321 0.238246655576804 848 17156417 SGTC_2118 5526350 200 µM -0.712450112907851 0.323777583017607 no 2322 0.238093046524481 844 743594 SGTC_3097 9117246 49.47 µM -0.714530884033526 0.323242933183541 no 2323 0.23744948291588 834 16423892 SGTC_1946 st076057 65.1 µM -0.71663145454285 0.322703565997141 no 2324 0.236800765355418 840 953009 SGTC_109 0132-0036 33.701 µM -0.71691163427959 0.322631651908471 no 2325 0.236714311392131 816 67274 A color developer. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.717919054634015 0.322373130875571 no 2326 0.236403599125559 834 551469 SGTC_2453 5731132 22.18 µM -0.718212962006811 0.32229772546954 no 2327 0.23631299346152 853 1362040 SGTC_476 mead acid 10 µM -0.718710060686336 0.322170205578168 no 2328 0.236159791578741 864 5312531 An omega 9 fatty acid. SGTC_2580 diallyl disulphide 81.36 µM -0.719151217822594 0.322057053805572 no 2329 0.236023876270142 837 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2235 salicylic acid 500 µM -0.719407713158642 0.321991273259591 no 2330 0.235944872903116 837 338 A COX inhibitor and kinase inhibitor. SGTC_2211 7117706 200 µM -0.719792413919971 0.321892623729621 no 2331 0.235826408191154 835 822771 SGTC_2904 7225135 42.03 µM -0.720220012730542 0.321782988502201 no 2332 0.235694771947719 875 4446116 SGTC_40 0327-0103 19.753 µM -0.720919824932196 0.321603591943504 no 2333 0.235479422301491 845 409036 SGTC_1004 4084-0029 199 µM -0.722284216162185 0.321253950457523 no 2334 0.235059877501338 838 716894 YLR208W SEC13 SGTC_3229 9132204 49.47 µM -0.72238538292131 0.321228031574755 no 2335 0.235028785583121 845 17682924 SGTC_3148 9097893 49.47 µM -0.722933001010694 0.321087747157583 no 2336 0.234860523726926 807 17174100 SGTC_702 1488-0190 94 µM -0.724150429122144 0.320775967663498 no 2337 0.234486693805728 818 949357 SGTC_1032 k061-1018 98.7 µM -0.724346498662115 0.320725766682978 no 2338 0.234426518447342 849 4005393 SGTC_2929 9013348 24.6 µM -0.728286828380629 0.319717594014161 no 2339 0.233219011792238 857 2995952 SGTC_398 bronopol 33.3 µM -0.730506836324381 0.319150168315002 no 2340 0.232540217887198 830 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_900 1112-0045 141 µM -0.730896474601945 0.319050621877632 no 2341 0.232421194759515 834 56211 YIL048W NEO1 SGTC_2588 indole-3-carbinol 100 µM -0.732893609985468 0.318540590242102 no 2342 0.231811660389566 840 3712 Induces cell cycle arrest. SGTC_3012 9080433 71.4286 µM -0.733355918395693 0.31842257412656 no 2343 0.231670688891903 856 17688859 SGTC_582 0987-0078 156 µM -0.734699554699343 0.31807968100753 no 2344 0.231261245789262 867 1625765 SGTC_1074 carmofur 3.8 µM -0.735653740196518 0.317836269533442 no 2345 0.230970724403136 856 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_947 3447-0010 211 µM -0.739067152055471 0.316966157504997 no 2346 0.229933110900003 860 748350 SGTC_2055 5235184 200 µM -0.739845291665793 0.316767943483595 no 2347 0.229696936702175 858 2836034 SGTC_1966 st070145 16.1 µM -0.741830147758168 0.316262583136696 no 2348 0.229095126075488 862 3748532 SGTC_619 1652-1634 108 µM -0.744727562237179 0.315525494007015 no 2349 0.228218216709567 859 5400454 SGTC_1618 st003135 44.5 µM -0.744849003579401 0.31549461587268 no 2350 0.228181503448033 870 1270615 SGTC_2288 7946289 167.31 µM -0.744980075830497 0.315461290392696 no 2351 0.228141882366562 867 1246052 SGTC_2642 cholecalciferol 100 µM -0.745730457044421 0.315270532807716 no 2352 0.227915128399899 844 9821465 A vitamin D precursor, similar to steriods. SGTC_460 trequinsin 123 µM -0.746401134941909 0.31510007860859 no 2353 0.227712566937062 874 5537 A vasodilator. SGTC_3286 9117135 37.221 µM -0.74786317890998 0.314728633531691 no 2354 0.227271344601237 851 3438150 SGTC_1906 st060206 94.7 µM -0.748216260989345 0.314638958013519 no 2355 0.22716486213849 863 5133468 SGTC_1809 st050081 57.6 µM -0.750812410726194 0.313979925870252 no 2356 0.226382779641469 857 5036894 SGTC_1500 4488-1866 171 µM -0.751226884799677 0.313874766528781 no 2357 0.226258061461496 873 2900003 SGTC_3221 9128209 49.47 µM -0.756482957636413 0.312542522319261 no 2358 0.224679843263878 872 16460723 SGTC_1813 st051246 8.6015 µM -0.756947718179178 0.312424838032854 no 2359 0.224540592728602 837 5291959 SGTC_2317 5986382 200 µM -0.760074477804858 0.311633593685811 no 2360 0.223605033706868 892 877883 SGTC_3302 9125395 16.351 µM -0.760753460497611 0.311461887954738 no 2361 0.223402168369872 844 17599668 SGTC_2781 5567276 71.43 µM -0.761614389421395 0.311244229385231 no 2362 0.223145092071863 865 2853274 SGTC_2161 5662504 8.5105 µM -0.761855465687401 0.311183292719831 no 2363 0.223073136076567 847 2859334 SGTC_2434 5670830 169.91 µM -0.762344598013718 0.311059671014005 no 2364 0.222927181377649 890 1549830 SGTC_83 0170-0301 39.027 µM -0.76432575454866 0.310559178099536 no 2365 0.222336570631417 855 3089716 SGTC_1509 1326-1131 80 µM -0.765253534721579 0.310324916544228 no 2366 0.222060293441306 825 768313 SGTC_133 0724-0033 378.92 µM -0.76578708532573 0.310190231542281 no 2367 0.221901499926577 856 280309 SGTC_588 3970-1144 52.9 µM -0.766307443052439 0.310058901358677 no 2368 0.221746695312457 832 1888707 SGTC_3323 9138564 53.9225 µM -0.768413408644929 0.309527636029716 no 2369 0.221120808381103 864 43912313 YNL103W MET4 SGTC_1910 st062352 60.4 µM -0.768822054316116 0.309424594316689 no 2370 0.22099947726483 866 2245730 SGTC_1646 st011709 75.6 µM -0.770557570262304 0.30898714373078 no 2371 0.220484609430391 861 5757843 SGTC_2309 7664088 163.95 µM -0.771330112148335 0.308792505459664 no 2372 0.220255644126138 862 704922 SGTC_644 1498-1197 63.3 µM -0.771607585576025 0.308722610445825 no 2373 0.220173440078216 870 6741615 SGTC_2697 mebhydrolin 72.4 µM -0.772272545150132 0.308555136630037 no 2374 0.219976511330797 880 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2768 sulfasalazine 50.2 µM -0.772596004551475 0.308473685950745 no 2375 0.219880754906676 877 5384001 An antioxidant and salicylic acid derivative. SGTC_739 1486-1183 203 µM -0.776075941396247 0.307597995923454 no 2376 0.218852073997473 868 4346692 SGTC_283 0987-0079 11.7 µM -0.776258227896183 0.307552155560857 no 2377 0.218798265929436 854 411556 SGTC_1892 st058411 7.36 µM -0.777955877238661 0.307125384838851 no 2378 0.218297512628197 867 3934738 SGTC_2856 9022925 19.48 µM -0.781219490950166 0.306305681453847 no 2379 0.217336705994575 855 4944862 SGTC_2220 6782180 200 µM -0.781351722974824 0.306272489873586 no 2380 0.21729782848168 849 833803 SGTC_1363 1636-0063 10.4 µM -0.781468035811337 0.306243295485371 no 2381 0.217263634686698 845 6072185 SGTC_2469 5655019 90.81 µM -0.782450447083438 0.305996760478222 no 2382 0.216974948177844 862 2788239 SGTC_3275 9138069 49.47 µM -0.784359601832509 0.30551791157566 no 2383 0.216414567925525 864 17617007 SGTC_1472 k841-0093 193 µM -0.784927455510633 0.305375548207503 no 2384 0.216248051741727 875 X1472 SGTC_985 1493-0307 8.71 µM -0.786092237352487 0.30508362448363 no 2385 0.21590672586404 878 3278274 SGTC_2865 9030313 51.95 µM -0.787220866579041 0.304800879774172 no 2386 0.215576292081876 879 42562754 SGTC_2024 5144227 134 µM -0.788514353102312 0.304476978253104 no 2387 0.215197953188306 858 3475211 SGTC_959 1222-0044 107 µM -0.788584634586804 0.304459383478628 no 2388 0.215177407220656 855 6083612 SGTC_611 3453-1652 23.7 µM -0.789326504697843 0.3042736859612 no 2389 0.214960599650199 873 1560575 SGTC_2320 7373003 200 µM -0.789520156020289 0.304225221399241 no 2390 0.214904026974682 851 5415828 SGTC_1876 myriocin 605 nM -0.790382492158815 0.304009448764241 no 2391 0.214652211883136 875 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1860 st056228 74.6 µM -0.791810453708194 0.303652296181267 no 2392 0.214235603006225 890 688679 SGTC_2142 5622915 118.518 µM -0.792341817128558 0.30351944280363 no 2393 0.214080697490534 872 5322196 SGTC_270 tamoxifen 5.46 µM -0.792555367767498 0.303466057425187 no 2394 0.214018460590652 889 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_129 0088-0017 176.636 µM -0.793415780763542 0.303251005876808 no 2395 0.213767809750203 859 182446 SGTC_2871 9038510 12.99 µM -0.794091754529056 0.303082100858596 no 2396 0.213571008722868 876 4945164 SGTC_980 1473-0395 201 µM -0.797585124093394 0.302209887010172 no 2397 0.21255564323803 877 768876 SGTC_1381 2324-0066 62.1 µM -0.800393435031742 0.301509534427756 no 2398 0.211741441715871 858 10885928 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.801094080873619 0.301334917271484 no 2399 0.211538591324819 864 15053 SGTC_1488 4013-0813 75.9 µM -0.802171569387505 0.301066471095872 no 2400 0.211226859894048 855 2910057 SGTC_3088 9117578 49.47 µM -0.80326792863419 0.300793434140556 no 2401 0.210909945354919 896 678341 SGTC_3095 9117207 49.47 µM -0.803601089839933 0.300710485917773 no 2402 0.210813696754302 862 17015229 SGTC_214 4373-3496 70 µM -0.805860471730909 0.300148232900075 no 2403 0.210161652696893 877 3779166 SGTC_1308 1187-1617 41.4 µM -0.807991896031107 0.299618258673572 no 2404 0.209547623678404 875 2882570 SGTC_790 1575-0012 79.1 µM -0.808482508839029 0.299496328874392 no 2405 0.209406435582659 870 378741 YLR208W SEC13 SGTC_2040 5100729 123 µM -0.810085486644458 0.299098104888815 no 2406 0.20894552251942 870 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2639 lactacystin 53 µM -0.81029086710692 0.299047100082498 no 2407 0.208886511558867 857 3870 A proteasome inhibitor. SGTC_2601 securinine 100 µM -0.812115295339521 0.298594189512152 no 2408 0.208362738697537 878 442872 A GABA receptor antagonist. SGTC_252 miconazole 1.30953 nM -0.814654129669382 0.297964448753651 no 2409 0.207635158405466 860 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_9 0092-0002 10.449 µM -0.815178237759168 0.297834522697798 no 2410 0.207485146417454 876 759368 SGTC_2101 5377231 179.231 µM -0.815564344229128 0.297738823685064 no 2411 0.207374674709235 885 2844213 SGTC_2621 lithochol-11-enic acid 100 µM -0.817863613665161 0.297169225455493 no 2412 0.206717534603362 890 6708711 SGTC_1240 0356-0016 42.1 µM -0.823033221218119 0.295890380754184 no 2413 0.205244550895214 835 4305613 SGTC_3179 9107801 49.47 µM -0.825073019500592 0.295386476808771 no 2414 0.204665068177618 852 4818259 SGTC_2918 7977171 22.06 µM -0.825659182178917 0.295241746489733 no 2415 0.204498726458535 853 2236483 SGTC_1819 st053448 58.6 µM -0.825685991692407 0.295235127692634 no 2416 0.204491120357737 916 2857616 SGTC_2350 9023895 38.85 µM -0.825712265588835 0.295228641196231 no 2417 0.204483666379687 868 2997209 SGTC_2750 bromebric acid 70.15 µM -0.825944677010916 0.295171266349117 no 2418 0.204417737649942 896 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_981 1488-1094 54.9 µM -0.826472258488688 0.295041042640363 no 2419 0.204268124260871 867 3449522 SGTC_229 benomyl 22.8748 µM -0.829044681606579 0.294406467109248 no 2420 0.203539562122193 863 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2710 st078562 53.7235 µM -0.830724871653515 0.293992331651851 no 2421 0.203064536260551 883 17250908 SGTC_2252 omeprazole 400 µM -0.831530876109783 0.293793762250975 no 2422 0.202836896596393 865 4594 A proton pump inhibitor. SGTC_595 3909-8003 73.7 µM -0.832577119064241 0.2935360996472 no 2423 0.202541633912793 893 699517 SGTC_1080 nisoldipine 24.4 µM -0.833375431121969 0.293339566431369 no 2424 0.20231651330527 878 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2047 4141938 200 µM -0.837449711004808 0.292337487002409 no 2425 0.201169916573503 887 3807862 SGTC_3305 9127027 53.8275 µM -0.838373529915047 0.292110493002382 no 2426 0.200910475504557 882 41905295 SGTC_1725 st036284 20.55 µM -0.839629037306521 0.291802130508867 no 2427 0.200558206558114 876 707914 SGTC_2853 9015042 58.44 µM -0.840623062516535 0.291558097720188 no 2428 0.200279567252685 872 6457456 SGTC_2654 protoveratrine a 100 µM -0.841779219033017 0.29127438153432 no 2429 0.199955773027738 898 5702278 A heart drug and vasodilator. SGTC_570 0987-0065 62.6 µM -0.84246995211879 0.291104939913932 no 2430 0.199762475996275 849 3104428 SGTC_1451 4152-0210 104 µM -0.842601138128822 0.291072764277675 no 2431 0.199725777175093 888 659563 SGTC_1482 3346-2049 8.48 µM -0.844001569012156 0.290729387962971 no 2432 0.199334264418502 871 3826804 SGTC_2504 purpurogallin 52.29 µM -0.84419733371315 0.29068140285887 no 2433 0.199279572117099 871 5281571 An antioxidant. SGTC_1484 3473-2379 286 µM -0.846114141991407 0.290211757879049 no 2434 0.198744536114534 918 671917 SGTC_1740 st038286 13.222 µM -0.846821876223245 0.290038442943224 no 2435 0.198547206389624 879 716786 SGTC_1700 st030840 7.9285 µM -0.848760900480533 0.289563849782127 no 2436 0.198007175430826 890 5499307 SGTC_312 4092-0653 6.84 µM -0.851127984357605 0.288984980033527 no 2437 0.197349130857729 873 1148278 SGTC_516 3992-2719 87.3 µM -0.852304225306283 0.288697533243953 no 2438 0.197022630747882 910 5350887 YDR037W KRS1 SGTC_3052 9092717 49.47 µM -0.852869162891462 0.28855952310643 no 2439 0.196865932074395 898 25237534 SGTC_950 1165-0508 94.1 µM -0.856941542412434 0.287565591283649 no 2440 0.195738596243435 897 6148369 SGTC_1257 0669-0121 16 µM -0.856954113815849 0.287562525531396 no 2441 0.19573512224457 878 4307855 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.857008830094577 0.28754918220873 no 2442 0.195720002308986 891 641818 YHR062C RPP1 SGTC_1751 st044839 27.194 µM -0.859273940521895 0.286997060701718 no 2443 0.195094698965002 864 5291326 SGTC_1434 4073-0095 163 µM -0.859476209768881 0.286947781929995 no 2444 0.195038919911023 878 24133745 SGTC_3125 9127534 49.47 µM -0.859698583717506 0.286893609684675 no 2445 0.1949776078463 863 1639235 SGTC_1297 1068-0111 14.1 µM -0.860589650248682 0.286676586685418 no 2446 0.194732044092751 886 767057 SGTC_623 k072-0108 16.9 µM -0.861628694137614 0.286423621532019 no 2447 0.194445937860391 900 5382803 SGTC_1682 st012968 530 nM -0.861894055317623 0.286359033805913 no 2448 0.194372910295289 884 24207270 SGTC_2137 5261020 140 µM -0.862827557331826 0.286131878540517 no 2449 0.194116142669001 887 763655 SGTC_3256 9138902 49.47 µM -0.866625796101044 0.285208511594909 no 2450 0.193073537365689 910 17228773 SGTC_187 1488-2104 32.728 µM -0.869926125564974 0.284407343103269 no 2451 0.192170388530324 881 2852859 SGTC_845 0330-0138 4.51 µM -0.871021860427561 0.28414158695292 no 2452 0.191871108559373 893 9039800 SGTC_3220 9131269 49.47 µM -0.873353457903973 0.283576484044692 no 2453 0.191235225498412 911 17722206 SGTC_2250 alverine citrate 130 µM -0.876857836802455 0.282728151581841 no 2454 0.190281929950516 871 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_72 0744-0168 198.391 µM -0.884045715478415 0.280991950840449 no 2455 0.188335767600412 926 677577 SGTC_1242 0402-0103 60.1 µM -0.885561369591456 0.280626510012357 no 2456 0.18792696795393 892 432868 SGTC_872 0588-0139 234 µM -0.885800480519208 0.280568878751589 no 2457 0.187862525432049 878 2047100 SGTC_2413 inermin 26.06 µM -0.887672288672893 0.280117927729298 no 2458 0.187358528138812 901 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2325 6158266 200 µM -0.887921363282249 0.280057947829339 no 2459 0.187291526146718 897 3623240 SGTC_2028 5153890 36.43 µM -0.888743777901075 0.279859945585674 no 2460 0.187070398802617 911 2830968 YPR165W RHO1 SGTC_1334 1486-0610 236 µM -0.888937307123129 0.279813361901999 no 2461 0.187018386970631 868 3742339 SGTC_1017 4239-0030 168 µM -0.892056776775137 0.279063005628787 no 2462 0.186181250441003 873 1149593 SGTC_2627 acetyl isogambogic acid 100 µM -0.893825212912995 0.278638061568887 no 2463 0.185707708480079 915 6857789 A caspase activator and apoptosis inducer. SGTC_1763 st044482 94.5 µM -0.895082756563381 0.278336073579372 no 2464 0.185371425468559 893 88505 SGTC_2678 equilin 100 µM -0.895748399263115 0.278176289966047 no 2465 0.185193577340269 852 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2516 gossypol 71.55 µM -0.895920051564125 0.278135093097474 no 2466 0.185147732029879 913 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_864 0469-0573 172 µM -0.896640923860543 0.277962114914786 no 2467 0.184955276693553 928 689425 SGTC_1886 st057356 49.9 µM -0.8982791772662 0.277569200268718 no 2468 0.184518365423722 902 24207747 SGTC_626 0214-0009 33 µM -0.898998749856306 0.277396705578924 no 2469 0.184326663270906 915 3437874 SGTC_747 3448-8087 38.7 µM -0.899359097608821 0.27731034334085 no 2470 0.184230709200691 935 5168703 SGTC_1689 st020265 53.493 µM -0.900483509971562 0.277040947188304 no 2471 0.18393149846876 909 5758320 YPR016C TIF6 SGTC_866 0495-0101 262 µM -0.902130934751617 0.276646474802972 no 2472 0.183493658839825 889 635694 SGTC_2331 7980721 200 µM -0.902914514368979 0.276458944967265 no 2473 0.183285633374412 894 2981221 SGTC_2112 5488546 200 µM -0.90459676069717 0.27605655282112 no 2474 0.182839526033215 926 600757 SGTC_1756 st041558 35.5 µM -0.906827532305008 0.275523397717952 no 2475 0.18224900396887 939 3955792 SGTC_772 k072-0172 35.3 µM -0.90938282184413 0.274913305701306 no 2476 0.181574043090282 871 5861980 SGTC_3204 9114183 49.47 µM -0.910746388670291 0.274588017871881 no 2477 0.181214507967109 901 17027248 SGTC_159 3970-0959 50 µM -0.911597090719241 0.274385173528344 no 2478 0.180990427225484 880 6615653 SGTC_1642 st009582 77.7 µM -0.911811424787101 0.274334078638583 no 2479 0.180933997560097 911 6739311 SGTC_1310 1188-0297 994 nM -0.91641700835858 0.273237294336798 no 2480 0.179724108937019 892 1588352 SGTC_1698 5-fluorocytosine 1.055 µM -0.919712633168539 0.272453802259404 no 2481 0.178861474556101 900 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2905 7799065 20.05 µM -0.920107703401946 0.272359954377143 no 2482 0.17875823958508 886 1296806 SGTC_2377 9073351 62.6 µM -0.920280846259584 0.272318829813869 no 2483 0.178713007814208 935 7337946 YHR072W ERG7 SGTC_3156 9099931 49.47 µM -0.921103901667806 0.272123381452721 no 2484 0.178498091705084 920 18111053 SGTC_542 3381-0244 89.3 µM -0.923377391457934 0.271583865651011 no 2485 0.177905284746772 944 1112843 SGTC_1232 0279-0259 161 µM -0.925122318740977 0.271170143212543 no 2486 0.177451142388604 896 1560000 SGTC_1676 st018489 23.4 µM -0.927608104677755 0.270581306329174 no 2487 0.176805446044042 900 3696235 SGTC_1799 st045822 46.1415 µM -0.927967534297162 0.270496216958381 no 2488 0.176712205305828 870 3674992 SGTC_572 0960-0087 17.7 µM -0.92848336124464 0.270374126319139 no 2489 0.176578447390982 924 6796365 SGTC_534 k292-0788 63.4 µM -0.92907408594193 0.27023434203749 no 2490 0.176425346581528 926 4146317 SGTC_2911 7942208 15.64 µM -0.929295751148346 0.270181898314363 no 2491 0.176367918275138 878 1243384 SGTC_42 0133-0086 60.653 µM -0.929543026921594 0.270123401399693 no 2492 0.176303868823246 929 162923 Model of phenazepam hydroxylation. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.931150856644287 0.269743198961499 no 2493 0.175887767295921 925 521171 SGTC_2838 9002687 71.43 µM -0.932234881950394 0.269487011555817 no 2494 0.175607576107533 919 6457060 SGTC_3211 9128781 49.47 µM -0.933941320173841 0.269083976709525 no 2495 0.175167081450541 914 17194361 SGTC_671 0560-0003 407 µM -0.935505126337079 0.268714895198221 no 2496 0.174764021351986 896 3238678 SGTC_428 3448-4153 16.5 µM -0.935642563071615 0.268682470247434 no 2497 0.174728626161249 894 3834874 SGTC_2996 9066192 71.4286 µM -0.937729936963719 0.268190245480183 no 2498 0.174191607458035 891 6472854 SGTC_43 0570-0105 72.5 µM -0.938870435148626 0.267921495812076 no 2499 0.173898635091919 908 1114046 YDL195W SEC31 SGTC_2927 9011802 47.9 µM -0.941431621233712 0.267318466606359 no 2500 0.173241857656763 914 43912568 SGTC_1410 3909-8106 77.9 µM -0.942493596936915 0.267068626276071 no 2501 0.172969993910959 907 1039210 SGTC_3183 9108214 49.47 µM -0.9426561319732 0.267030398700661 no 2502 0.172928409250281 905 4974831 SGTC_3338 9144300 39.5675 µM -0.943586567481603 0.266811617273612 no 2503 0.172690479541738 908 4901274 SGTC_793 0488-0545 106 µM -0.947281548237578 0.265943679219256 no 2504 0.171747665322597 919 292548 SGTC_1768 st044301 37.178 µM -0.952986071068296 0.264606521567782 no 2505 0.170298564058949 951 3931349 SGTC_2807 7945238 51.95 µM -0.954494075815038 0.264253613040633 no 2506 0.169916803313849 931 17148797 SGTC_676 falcarinol 140 µM -0.956428790084252 0.263801195737919 no 2507 0.169427822570837 919 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1248 0469-0687 58.6 µM -0.958667985524201 0.263278071514825 no 2508 0.168863015676001 927 4017482 SGTC_2670 beta-carotene 100 µM -0.960952186182997 0.262744979518592 no 2509 0.16828810471967 873 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1670 st016595 4.04 µM -0.961825271456127 0.262541362827865 no 2510 0.168068690677196 932 597879 SGTC_154 3389-1638 511.116 µM -0.962964590250184 0.262275777968114 no 2511 0.167782646783058 957 5238686 SGTC_1555 citronellol 128 µM -0.963948178181097 0.262046606031072 no 2512 0.167535953843962 915 8842 A terpine precursor. SGTC_1792 st045773 43.6 µM -0.964883912038422 0.261828679209701 no 2513 0.167301480149187 857 2919270 SGTC_2486 5283202 22.39 µM -0.968571900493687 0.260970674845795 no 2514 0.166379414465322 920 1377751 SGTC_2100 5377183 190 µM -0.975773739026429 0.259299357313384 no 2515 0.164588300599651 899 2844202 SGTC_1968 st069590 43.6 µM -0.979084176736914 0.258532969794705 no 2516 0.163769194632907 917 6384066 SGTC_1791 st048313 56.1 µM -0.979894599883872 0.258345530554937 no 2517 0.163569074420165 875 1204976 SGTC_386 1509-0011 3.07 µM -0.981295505330269 0.258021687385597 no 2518 0.163223519292685 924 3107280 SGTC_1132 3456-3614 2.5 µM -0.982201850338616 0.257812282521344 no 2519 0.163000208102626 940 3125502 SGTC_2943 9068529 45.32 µM -0.983534174507097 0.257504618261639 no 2520 0.162672302132584 930 3270634 SGTC_2063 5246145 200 µM -0.985173619028662 0.257126294751812 no 2521 0.162269398292461 936 711240 SGTC_2283 7944793 200 µM -0.98540990495437 0.257071792489508 no 2522 0.16221138314382 893 2970533 SGTC_2652 actinonin 100 µM -0.986369768577153 0.256850449905643 no 2523 0.161975847255145 922 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2779 methotrexate 400 µM -0.988436242226934 0.256374262148878 no 2524 0.161469522638969 915 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3300 9124615 50.48 µM -0.990011537354767 0.256011568374442 no 2525 0.161084239908754 932 24824903 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.9950009530717 0.25486458117726 no 2526 0.159867900407086 923 5355888 SGTC_533 1222-0222 6.71 µM -0.997287056431844 0.254339942362568 no 2527 0.159312597310995 945 3982874 SGTC_1337 1486-1011 40.3 µM -0.998553579677966 0.254049531290951 no 2528 0.159005498421968 911 X1337 SGTC_1919 st067113 52.3 µM -0.998820338684154 0.253988386207715 no 2529 0.15894086579803 939 1268243 SGTC_399 oxolinic acid 75 µM -1.00009767466647 0.253695709081112 no 2530 0.158631620675885 910 4628 A DNA gyrase inhibitor. SGTC_1949 st076024 69.1 µM -1.00277083224 0.253083779752383 no 2531 0.157985722512122 935 2921930 SGTC_926 2268-1401 59.4 µM -1.00477544944362 0.252625400186346 no 2532 0.157502494020394 937 2931578 SGTC_1513 0337-0559 19 µM -1.00645667428832 0.252241305567998 no 2533 0.157097971456488 926 775073 SGTC_1199 1638-0010 4.46 µM -1.00665439063167 0.252196155303375 no 2534 0.157050443512096 919 3111136 SGTC_357 1325-0123 420 µM -1.00899209199739 0.251662643923957 no 2535 0.156489213384675 956 1098503 SGTC_1430 4049-0248 69.1 µM -1.01067107379247 0.251279833988189 no 2536 0.156086943036487 936 22774488 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.01213102313417 0.25094721414867 no 2537 0.155737705453181 961 442882 SGTC_397 arbidol 50 µM -1.01226801323655 0.250916015695226 no 2538 0.155704962223537 929 131410 A RNA synthesis inhibitor. SGTC_2412 st077135 33.4 µM -1.01276181889984 0.250803572252364 no 2539 0.155586970995261 958 13258915 SGTC_1753 st043925 64 µM -1.01434438289737 0.25044338978418 no 2540 0.155209226465684 947 670181 SGTC_600 1495-0418 41.6 µM -1.01443415008734 0.250422967506852 no 2541 0.155187817961914 942 5377768 SGTC_1200 1643-0193 18.4 µM -1.01527964710432 0.25023065797508 no 2542 0.15498627171957 933 5403974 SGTC_2944 9067346 25.62 µM -1.01624345214809 0.250011534664949 no 2543 0.154756734603417 936 6473075 SGTC_3345 9148410 3.559 µM -1.01634776861557 0.24998782418218 no 2544 0.154731904362102 905 4903596 SGTC_1695 st026914 34.495 µM -1.0179155933224 0.249631611182086 no 2545 0.154359035253542 942 3289191 SGTC_979 1426-2828 121 µM -1.01826314788143 0.249552682595224 no 2546 0.154276458340297 949 747872 SGTC_2459 5811157 9.22 µM -1.01842517160689 0.249515892030045 no 2547 0.154237972444512 932 2870684 YBR192W RIM2 SGTC_569 4130-2812 160 µM -1.01957039114686 0.249255930372921 no 2548 0.153966126679454 931 743552 SGTC_2009 4012297 12.05 µM -1.02009131975539 0.249137728695956 no 2549 0.153842576549412 925 45595307 SGTC_495 decylubiquinone 155 µM -1.02243501898649 0.248606298987869 no 2550 0.153287526619137 956 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2628 lathosterol 100 µM -1.02261898592186 0.24856461038112 no 2551 0.153244014618625 943 6710616 SGTC_2167 5876490 200 µM -1.02568295164374 0.247870835346578 no 2552 0.152520526426164 927 686534 SGTC_2716 st080858 38.6235 µM -1.02578566991486 0.247847594725562 no 2553 0.152496311092925 919 5296050 SGTC_1332 1480-0653 17.5 µM -1.02859011779235 0.247213521342046 no 2554 0.151836161831136 942 5749438 SGTC_1442 4112-3290 3 µM -1.02977443144017 0.246946013951744 no 2555 0.151557952984459 959 704353 SGTC_1339 1486-1321 22.7 µM -1.02982216023317 0.246935236436788 no 2556 0.151546748052393 938 3469382 SGTC_330 1488-0319 80.1 µM -1.03008880978446 0.246875029624913 no 2557 0.151484158862944 918 6846614 SGTC_1397 3532-0190 20.1 µM -1.03153685079267 0.246548213625353 no 2558 0.151144568247519 904 5322280 SGTC_2173 5763948 167 µM -1.03273778220345 0.246277345013596 no 2559 0.150863313604746 937 2867177 SGTC_2373 9071805 200 µM -1.03276314534209 0.246271626109498 no 2560 0.150857377390536 968 10149009 SGTC_843 0310-0051 143 µM -1.03555307970275 0.245642984000966 no 2561 0.150205345588818 936 2065037 SGTC_3284 9108171 64.8615 µM -1.0359090746619 0.24556283146225 no 2562 0.150122281820473 914 8687505 SGTC_2134 5324836 1.464 µM -1.03792201502664 0.245109880816769 no 2563 0.149653181637186 958 699272 SGTC_1939 st074455 53.6 µM -1.0389941673404 0.244868809272935 no 2564 0.149403724455931 934 1644229 SGTC_3058 9093861 49.47 µM -1.03905521840207 0.244855085891078 no 2565 0.149389528091567 912 17217477 SGTC_998 3996-0085 177 µM -1.03961045262418 0.244730296397259 no 2566 0.149260459349989 930 715391 SGTC_2103 5378138 10 µM -1.0413136363714 0.244347717708191 no 2567 0.148865004977148 923 244142 SGTC_1908 st060353 56.5 µM -1.0413256624596 0.244345017487277 no 2568 0.14886221518675 950 4227716 SGTC_2591 skatole 100 µM -1.04139414826388 0.244329640657233 no 2569 0.148846328638523 945 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_124 0136-0217 7.121 µM -1.04201371806629 0.244190554956022 no 2570 0.148702659458436 929 3976905 SGTC_3281 9140613 49.47 µM -1.04248247398935 0.244085353465464 no 2571 0.148594023426982 917 16013766 SGTC_2980 9014342 25.29 µM -1.04300376022702 0.24396839146563 no 2572 0.148473275617063 918 2996599 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.04538890897888 0.243433616933336 no 2573 0.147921630317357 958 75037 A free radical scavenger. SGTC_1211 1056-0033 32.3 µM -1.04792731198375 0.242865177640424 no 2574 0.147336048849137 919 6741922 SGTC_258 haloperidol 50.781 µM -1.04838590753108 0.242762558338465 no 2575 0.147230421852402 937 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2966 9084041 48.03 µM -1.05056866651972 0.242274447181675 no 2576 0.146728369126604 953 17741380 SGTC_1625 st003711 30.1 µM -1.05150298577425 0.242065676283008 no 2577 0.14651381940566 943 24207034 YER133W GLC7 SGTC_2061 5245884 80.95 µM -1.05152157778607 0.242061522942646 no 2578 0.1465095522203 952 573863 SGTC_18 0111-0177 500 nM -1.05338088495963 0.241646360469442 no 2579 0.146083230661206 951 721752 SGTC_1125 tnp00248 1.32998 µM -1.05462967127847 0.241367737619691 no 2580 0.145797364045166 936 24207736 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.05867284307222 0.240466844252074 no 2581 0.144874399919266 977 4620898 SGTC_785 1270-0111 65.3 µM -1.05914395058525 0.240361992044345 no 2582 0.144767113260627 935 6741994 SGTC_543 3844-1095 191 µM -1.05950017599755 0.240282725150527 no 2583 0.144686024565137 954 4230703 SGTC_127 0180-0333 59.125 µM -1.05974980991952 0.240227185369079 no 2584 0.144629217856029 885 771601 SGTC_823 0417-1665 178 µM -1.06089057316779 0.239973471810262 no 2585 0.144369816927182 966 3429856 SGTC_1510 1123-0200 71.5 µM -1.0625076716843 0.239614068547785 no 2586 0.144002638557622 954 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2506 ethyl hematommate 54.16 µM -1.06253539603646 0.239607909319918 no 2587 0.143996348962952 944 3940691 An allergen. SGTC_530 4358-1714 28 µM -1.06348334404013 0.239397365679157 no 2588 0.143781407298418 913 1564641 SGTC_3263 9137018 49.47 µM -1.06412630140646 0.239254619398603 no 2589 0.143635743744623 937 43844957 SGTC_1041 0206-0046 107 µM -1.06774562494706 0.238451943069332 no 2590 0.142817635854869 963 50494 SGTC_3013 9080133 71.4286 µM -1.06861203810222 0.238260013044297 no 2591 0.14262226094207 957 17050193 SGTC_1489 4065-0444 182 µM -1.06996700503381 0.237960027090324 no 2592 0.142317080331977 905 2877968 SGTC_833 3852-0053 558 µM -1.07142472277558 0.23763752374307 no 2593 0.141989250730946 976 3123681 SGTC_220 paclitaxel 373.376 µM -1.07184422748071 0.23754475759345 no 2594 0.141895002129672 947 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_838 0109-0203 71.4 µM -1.07392887646272 0.23708406873495 no 2595 0.14142727995136 932 759422 SGTC_2952 9073731 13.78 µM -1.07396621187068 0.237075822419825 no 2596 0.141418912729154 972 16457353 SGTC_2166 5933061 31.504 µM -1.07446704571674 0.236965217903319 no 2597 0.141306703506607 950 2877375 SGTC_552 k242-0005 476 µM -1.07743693904466 0.236309927599473 no 2598 0.140642554524858 960 4088318 SGTC_2694 st077685 81.9 µM -1.07843462696767 0.236090017454418 no 2599 0.140419920512642 950 2838096 SGTC_2131 toluylene red 5.2905 µM -1.08078314341955 0.23557280334647 no 2600 0.139896794203877 907 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2219 9098279 200 µM -1.08080138256956 0.235568788983562 no 2601 0.13989273666788 928 902349 SGTC_2271 7849410 118.62 µM -1.08141288012823 0.23543422269718 no 2602 0.139756747379943 970 972430 SGTC_2757 clomiphene 4.22 µM -1.08210606249459 0.235281732148846 no 2603 0.139602701140603 956 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_236 1509-0011 5.31 µM -1.08777349788794 0.23403702226799 no 2604 0.138347555964177 955 3107280 SGTC_1633 st005664 67.9 µM -1.0879193659214 0.234005034233489 no 2605 0.138315352988205 968 2063822 SGTC_1574 spiramycin 23.7 µM -1.08821297247637 0.233940655320923 no 2606 0.138250549586601 945 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2145 5634607 200 µM -1.09058595834778 0.233420692601847 no 2607 0.137727555469553 970 308662 SGTC_700 3453-2283 142 µM -1.09080203142852 0.233373379077539 no 2608 0.137680001205546 944 565664 SGTC_2046 4110841 106 µM -1.09101981804078 0.23332569572613 no 2609 0.13763208116093 939 44119630 YMR134W ERG29 SGTC_1328 1441-0025 69.2 µM -1.09124968819428 0.233275372605392 no 2610 0.137581514699346 948 4562601 SGTC_1814 st052110 31.539 µM -1.09248393532913 0.233005274531258 no 2611 0.137310223883296 949 674163 SGTC_2651 TUB2.036 5 µM -1.09456467011583 0.232550327681974 no 2612 0.136853700384397 925 15992207 YFL037W TUB2 SGTC_650 1328-0195 38 µM -1.09590169476299 0.232258251820969 no 2613 0.13656089867174 958 2780821 SGTC_1658 st012944 20 µM -1.10095062915929 0.231157144245013 no 2614 0.13545907258757 952 24207260 SGTC_2102 5377816 72.7585 µM -1.10377766344808 0.230541878831671 no 2615 0.134844798227044 950 1379702 SGTC_2979 9012552 45.46 µM -1.10396695323042 0.230500715212886 no 2616 0.134803736621579 970 17100905 SGTC_1278 0874-0585 172 µM -1.10397159856599 0.230499705073595 no 2617 0.134802729041998 962 766306 SGTC_3195 9113082 49.47 µM -1.103973677089 0.230499253094616 no 2618 0.134802278209216 952 17018038 SGTC_1985 st071382 65.5 µM -1.10490625571298 0.230296511988583 no 2619 0.134600105744613 982 6123237 SGTC_186 3455-3465 67.277 µM -1.10573812089622 0.230115750006151 no 2620 0.134419942511328 940 755278 SGTC_651 3253-0966 34.4 µM -1.10655445564324 0.229938439941477 no 2621 0.134243303853008 953 781462 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.10997919236387 0.229195412041446 no 2622 0.133503996469552 936 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2657 nystatin 74.44 µM -1.11131948156217 0.228904991060052 no 2623 0.133215428342975 943 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3258 9138477 49.47 µM -1.1125948558856 0.22862882804454 no 2624 0.132941235377579 983 4970355 SGTC_2017 5132927 60.65 µM -1.11391475675616 0.228343220607211 no 2625 0.132657879034902 966 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1399 3562-5772 25 µM -1.11823141061071 0.227410560782293 no 2626 0.131734086142747 936 23847490 SGTC_1000 4048-0884 8.67 µM -1.11859885010257 0.227331270727914 no 2627 0.131655657129689 968 13040088 SGTC_1739 st037196 92.5 µM -1.12097890887407 0.226818053371892 no 2628 0.131148420094338 950 612214 SGTC_763 3453-1109 128 µM -1.12147297387911 0.226711599024656 no 2629 0.131043294606244 958 1560353 SGTC_286 k060-0067 22.9 µM -1.12330100434599 0.226317965351186 no 2630 0.130654838708143 956 5985051 SGTC_567 1080-0542 68.4 µM -1.12440705532248 0.226079984633157 no 2631 0.13042019017009 913 5950415 SGTC_717 1532-0246 73.2 µM -1.12466981391012 0.226023469631348 no 2632 0.130364488851763 948 9561992 SGTC_2999 9069765 71.4286 µM -1.12509380191849 0.225932293704823 no 2633 0.13027464374959 941 2097066 SGTC_253 dyclonine 31.25 µM -1.12566896882474 0.225808640963614 no 2634 0.130152831598907 967 3180 An oral anasthetic. SGTC_1449 4112-4002 201 µM -1.12584010249343 0.225771857037772 no 2635 0.130116603147187 958 2059539 SGTC_955 1216-0110 33 µM -1.12662913465229 0.225602304212402 no 2636 0.129949657825334 957 3619719 SGTC_1490 4089-0339 670 nM -1.12695151333332 0.22553304993488 no 2637 0.129881490855554 953 742542 SGTC_874 0599-0792 117 µM -1.12781433254188 0.225347755941024 no 2638 0.129699169553763 962 765305 SGTC_1847 st056231 15 µM -1.13015086964617 0.224846407962964 no 2639 0.129206328894826 951 5393180 SGTC_305 1682-2595 20.8 µM -1.13504614067314 0.223798088464957 no 2640 0.128177993159215 948 226033 SGTC_1458 k015-0034 6.33 µM -1.13632982335828 0.223523649046845 no 2641 0.127909276849014 975 3598957 SGTC_1011 4112-3381 17.4 µM -1.13659298563215 0.223467411054021 no 2642 0.12785423685645 948 2877139 SGTC_696 1560-0013 611 µM -1.13673341767602 0.223437403905653 no 2643 0.127824872442003 961 1650269 SGTC_2512 diallyl trisulfide 49.23 µM -1.13899437897888 0.222954603333076 no 2644 0.127352749339915 996 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_381 3461-2219 42.7 µM -1.14041899041994 0.222650700440698 no 2645 0.127055892437964 994 2883159 SGTC_24 0417-1663 219 µM -1.14117491707695 0.222489539567854 no 2646 0.126898570072088 995 4329390 SGTC_2932 9016711 44.54 µM -1.14122394355793 0.2224790895942 no 2647 0.126888371436176 976 7117328 SGTC_2682 pyrogallin 40.03 µM -1.14248235221873 0.222210956135684 no 2648 0.126626788754647 957 822798 An ATP competetive kinase inhibitor. SGTC_1129 3453-1384 223 µM -1.14378260826694 0.221934099921518 no 2649 0.126356902109266 973 1084452 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.14406486828377 0.221874025913297 no 2650 0.12629836801456 979 115019 SGTC_2158 5657123 3.6195 µM -1.14427219132996 0.221829906818746 no 2651 0.126255386125538 986 2858827 SGTC_3047 9092122 49.47 µM -1.14774741483065 0.221091113039561 no 2652 0.125536425593925 968 17173831 SGTC_2291 7917025 104.35 µM -1.14856260015643 0.220918017815673 no 2653 0.125368193086396 956 2964612 SGTC_472 calcifediol 10 µM -1.14904494249088 0.220815634513891 no 2654 0.125268724635567 984 5283731 A vitamin D metabolite. SGTC_2223 6903751 107.57 µM -1.14964230397733 0.220688874600931 no 2655 0.125145613372469 948 5598863 SGTC_479 n-linoleoylglycine 10 µM -1.1501258642373 0.220586293803836 no 2656 0.125046017501615 983 6433346 An anti-infammatory. SGTC_261 5-fluorouridine 15.376 µM -1.15043634830726 0.220520443193546 no 2657 0.124982098239855 976 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2295 7971645 200 µM -1.15193223709311 0.220203337846024 no 2658 0.124674459960846 991 2978226 YKL099C UTP11 SGTC_2546 rhodinyl acetate 100 µM -1.15464405084698 0.219629142385338 no 2659 0.124118109863099 946 6708682 SGTC_344 k064-0035 6.43 µM -1.15548579019376 0.219451088749467 no 2660 0.123945774150267 936 5088750 SGTC_1863 st057641 20.1 µM -1.15596920831161 0.219348868522424 no 2661 0.12384687601424 988 3921635 SGTC_2953 9074162 66.49 µM -1.15674284027343 0.219185338643055 no 2662 0.123688720612224 926 16451992 SGTC_944 3370-0224 231 µM -1.15677926810999 0.219177640276083 no 2663 0.123681277071632 965 4580514 SGTC_2896 9052656 71.43 µM -1.15748647819511 0.219028214971298 no 2664 0.123536830310781 940 6469436 SGTC_2013 4024628 200 µM -1.16165046173636 0.218149602291418 no 2665 0.122688737840848 987 5230760 SGTC_1614 st002383 48.6 µM -1.1617517246809 0.218128260844718 no 2666 0.122668164269722 940 1947235 SGTC_1443 4112-3303 14 µM -1.16176720502254 0.218124998425782 no 2667 0.122665019345242 968 704433 SGTC_3320 9137005 35.139 µM -1.16189140770257 0.218098824234962 no 2668 0.12263978887133 966 4908713 SGTC_2182 6325192 200 µM -1.16195126368771 0.218086210967021 no 2669 0.122627631054774 930 736248 SGTC_2680 butyl paraben 22.24 µM -1.16196021006862 0.218084325759766 no 2670 0.12262581395812 990 7184 An antifungal and steroid mimetic. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.16248257691767 0.217974267394426 no 2671 0.122519748937933 948 6708514 SGTC_395 anisomycin 6.25 µM -1.1634913269271 0.217761822786336 no 2672 0.122315107495691 980 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3117 9124945 49.47 µM -1.16366941347415 0.217724329840473 no 2673 0.122279004657597 954 17592065 SGTC_2502 avocadyne acetate 18.59 µM -1.16723577129085 0.216974281258886 no 2674 0.121557584349732 954 3952079 SGTC_1305 1181-0477 144 µM -1.16753164200967 0.21691212319307 no 2675 0.121497868844427 985 6252086 SGTC_3330 9141424 71.43 µM -1.16852059926765 0.21670443260607 no 2676 0.121298417546538 958 27261020 SGTC_404 fumagillin 50 µM -1.16925320687893 0.216550652106697 no 2677 0.121150814962567 959 12015870 A methionine aminopeptidase binder. SGTC_1737 st035557 69.7 µM -1.16983531407148 0.216428507936865 no 2678 0.121033624652654 951 5716916 SGTC_1235 benzylparaben 21.5 µM -1.17692953426136 0.214943127273146 no 2679 0.119611816376945 991 7180 SGTC_840 0245-0196 390 µM -1.17794729489155 0.214730516278653 no 2680 0.119408809286743 975 3827528 SGTC_2730 imipramine 71.33 µM -1.17891606379618 0.214528253261521 no 2681 0.119215800258652 956 3696 A tricyclic antidepressant. SGTC_1151 3909-8316 15.3 µM -1.18215014036682 0.213853833833829 no 2682 0.118573066130352 991 800431 SGTC_1704 st028805 70.8 µM -1.18220864780431 0.213841644342591 no 2683 0.118561461069427 969 2876101 SGTC_2321 7390090 138.78 µM -1.18306053893434 0.213664206428951 no 2684 0.118392577772586 990 649046 SGTC_1212 0520-0165 585 µM -1.186232651618 0.213004251106697 no 2685 0.117765217505247 1002 5403258 SGTC_3249 9135183 49.47 µM -1.18688514694972 0.212868647647659 no 2686 0.117636463396965 942 4902779 SGTC_504 lovastatin 124 µM -1.18720034265531 0.212803160820934 no 2687 0.117574302883712 980 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2276 7947513 42.08 µM -1.18792348802656 0.212652960534411 no 2688 0.117431777503154 986 2105100 SGTC_167 3672-0051 66.205 µM -1.19130272193457 0.21195190070792 no 2689 0.116767382868043 961 3237971 SGTC_2581 avocatin a 64 µM -1.1914549197008 0.211920357428129 no 2690 0.116737521951431 994 6710728 A skin care supplement. SGTC_2086 5274770 176.623 µM -1.1929020123739 0.211620581892619 no 2691 0.11645387551351 951 689278 SGTC_1662 st014054 52 µM -1.19370652476721 0.211454028849516 no 2692 0.116296393648187 981 2838777 SGTC_2376 9072922 81.32 µM -1.19379000488031 0.211436750893887 no 2693 0.116280061222396 984 17087968 SGTC_484 loperamide 105 µM -1.20066213379018 0.210017257639854 no 2694 0.11494114415015 960 3955 An opioid-receptor agonist. SGTC_3033 9090887 49.47 µM -1.20093167135868 0.209961696855363 no 2695 0.114888853757937 976 19325384 SGTC_3287 9117173 37.0625 µM -1.20560685462618 0.208999358948732 no 2696 0.113984557471122 933 2789709 SGTC_1608 st001473 40.5 µM -1.20604499989407 0.208909304631553 no 2697 0.113900069944947 977 7292267 SGTC_2624 nerol 100 µM -1.20678193849875 0.208757889305391 no 2698 0.11375806678193 981 637566 A natural product oil. SGTC_2720 fluspirilene 36.88 µM -1.20820463886596 0.208465756734492 no 2699 0.113484278942971 980 3396 An atypical antipsychotic. SGTC_540 1187-0821 17.3 µM -1.20823849286709 0.208458808204095 no 2700 0.113477769727194 970 847520 SGTC_2463 5473429 200 µM -1.20900410223612 0.208301703431113 no 2701 0.113330634682687 958 5399405 SGTC_2777 climbazole 1.536 µM -1.20906755046077 0.208288686846931 no 2702 0.113318447292018 984 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1117 retinoic acid 1.10837 µM -1.21139127887695 0.207812298033112 no 2703 0.112872740105512 1002 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1787 fluconazole 80 µM -1.21783039936656 0.20649557720925 no 2704 0.111644214809822 935 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3245 9134821 49.47 µM -1.21801740413104 0.206457411037939 no 2705 0.111608679521241 974 17014901 SGTC_2202 7226349 200 µM -1.21833439604887 0.206392725079429 no 2706 0.11154846211295 979 844334 SGTC_2303 7774051 200 µM -1.21988173862962 0.206077143909733 no 2707 0.111254854698533 975 2953184 SGTC_1688 st021091 57.6 µM -1.22125114740725 0.205798091228026 no 2708 0.11099547197691 1013 3656366 SGTC_817 1391-0715 46 µM -1.22250983612623 0.205541798500711 no 2709 0.110757443268473 978 1353946 SGTC_601 0986-0029 62.9 µM -1.2250694492202 0.205021197937093 no 2710 0.1102745274021 953 24747981 SGTC_2314 7727897 200 µM -1.22560943270252 0.204911470717536 no 2711 0.110172843230693 939 900724 SGTC_1460 k062-0059 9.15 µM -1.22577855630478 0.204877111176632 no 2712 0.11014100943748 952 1373085 SGTC_1694 st024011 44.9 µM -1.22629404934099 0.204772403559932 no 2713 0.110044019934203 988 2787533 SGTC_2801 7907800 81.82 µM -1.22798948098624 0.204428249830371 no 2714 0.109725458380733 965 6620925 SGTC_1263 0774-1208 64.8 µM -1.22814391965995 0.20439691761892 no 2715 0.109696473201435 992 906585 SGTC_3115 9123671 49.47 µM -1.23054946180663 0.203909255135263 no 2716 0.109245708476575 1003 3286988 SGTC_3123 9126162 49.47 µM -1.23182645779895 0.203650658659288 no 2717 0.109006958871952 967 25239884 SGTC_1173 0443-0020 122 µM -1.23190831784486 0.203634088365392 no 2718 0.108991666962901 989 5331295 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.23330180086854 0.20335213975783 no 2719 0.108731593131669 970 6312947 SGTC_3084 9116877 49.47 µM -1.23699181758142 0.202606650917101 no 2720 0.108045060188583 966 27241325 SGTC_2247 cerulenin 830 nM -1.23783251021605 0.202437035731906 no 2721 0.107889085589458 955 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_79 0052-0007 94.094 µM -1.23829059525403 0.20234464985488 no 2722 0.107804164870203 942 2801472 SGTC_1452 4194-0072 190 µM -1.23985292056348 0.20202975222422 no 2723 0.107514900026106 978 1343545 SGTC_1824 st053723 68.6 µM -1.24056605110871 0.201886113303581 no 2724 0.107383049857659 985 675225 SGTC_966 1300-0360 30.2 µM -1.24082535462164 0.201833899490789 no 2725 0.107335136334034 939 70588 SGTC_443 clozapine 122 µM -1.24103915559379 0.201790854232305 no 2726 0.107295642262119 998 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1118 chelidonine 707.474 nM -1.24112603122692 0.201773364843919 no 2727 0.107279597281658 986 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1859 st055998 20 µM -1.24155459532049 0.20168710164798 no 2728 0.107200471489832 990 676301 SGTC_1059 3448-6867 171 µM -1.24350955724879 0.201293878921696 no 2729 0.106840060661238 985 3934407 SGTC_1209 2323-2347 50.3 µM -1.24388929782925 0.201217550916586 no 2730 0.10677015436825 954 5412760 SGTC_2075 5212009 200 µM -1.2441927948398 0.201156560377768 no 2731 0.10671430745994 978 780898 SGTC_3043 9092303 49.47 µM -1.24667701193055 0.20065775079054 no 2732 0.106257975560647 977 25236084 SGTC_1496 4469-0713 57.4 µM -1.24987547533872 0.200016621305572 no 2733 0.105672519752522 1016 746691 SGTC_2477 5967686 25.23 µM -1.25001778925695 0.199988123240069 no 2734 0.10564652451147 1002 776118 SGTC_1021 4476-0760 85.3 µM -1.25031559745767 0.199928495668813 no 2735 0.105592141449429 995 746768 SGTC_2430 5571206 200 µM -1.25038060958759 0.199915480271717 no 2736 0.105580272209856 981 1731771 SGTC_70 0141-0289 43.283 µM -1.25145489433558 0.199700482765473 no 2737 0.105384280129655 957 352408 SGTC_2053 5265679 138 µM -1.25466414811004 0.199059041131429 no 2738 0.104800352910872 966 764595 SGTC_2363 9053361 176 µM -1.25501670561711 0.198988650330879 no 2739 0.104736347797865 992 6469797 YMR079W SEC14 SGTC_1631 benzylvanillin 81.9 µM -1.25761937737243 0.198469471267001 no 2740 0.104264721036038 954 75506 SGTC_2144 5628481 200 µM -1.25913270061219 0.198167970743695 no 2741 0.103991202408567 965 2818399 SGTC_2115 tiliquinol 12.7705 µM -1.25939676425924 0.198115389493897 no 2742 0.103943528808035 982 71208 A bioactive hydroxyquinoline. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.26065628966203 0.197864704456145 no 2743 0.103716354330473 971 3256 An antibiotic and ribosome inhibitor. SGTC_2643 anethole 100 µM -1.26142049510807 0.197712697067832 no 2744 0.103578694006684 1013 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2139 5578692 56.4705 µM -1.2636081463079 0.19727794375532 no 2745 0.10318535410966 948 650991 YMR113W FOL3 SGTC_3224 9130643 49.47 µM -1.26591270759954 0.196820582847922 no 2746 0.102772168157495 990 17644395 SGTC_1292 0kpi-0043 232 µM -1.26857238464581 0.196293544867176 no 2747 0.102296809402203 986 3333905 SGTC_1428 4049-0204 61.7 µM -1.27330788762996 0.195357284412589 no 2748 0.101454404438015 987 X1428 SGTC_2010 4012422 159 µM -1.27340887920312 0.195337346870561 no 2749 0.101436494105889 979 952393 SGTC_2299 7976368 114.88 µM -1.27355183081 0.195309127781099 no 2750 0.101411146316577 990 2979718 SGTC_1550 gossypolone 36.6 µM -1.27374988194317 0.195270035967726 no 2751 0.101376036054257 996 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2278 7948257 134.34 µM -1.27388258472581 0.195243845430574 no 2752 0.101352515622506 979 1247028 SGTC_488 nitrendipine 139 µM -1.27611345506597 0.194803875180661 no 2753 0.100957707967664 1024 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2385 9074692 200 µM -1.27863522151005 0.194307261436527 no 2754 0.100512770416022 990 17046906 SGTC_932 2857-0803 154 µM -1.28111303000595 0.193820055968879 no 2755 0.100076983883731 989 674898 SGTC_1726 st035556 14.5795 µM -1.28153557133398 0.193737047076134 no 2756 0.100002806986053 976 5919439 SGTC_697 0508-1955 564 µM -1.28368395219931 0.193315329711195 no 2757 0.0996262808580622 992 6243113 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.28864278273134 0.192344074856247 no 2758 0.0987611513246987 1002 6708561 SGTC_284 0988-0104 32.6 µM -1.28940517465541 0.192195015071919 no 2759 0.0986286316883244 981 4666532 SGTC_2082 5219693 150 µM -1.29292899741221 0.1915069700906 no 2760 0.0980178086568557 982 2834649 SGTC_936 3005-4620 401 µM -1.29306917449553 0.191479631021449 no 2761 0.0979935676753057 984 777207 SGTC_31 0508-1974 57.237 µM -1.29327771008402 0.191438964255885 no 2762 0.0979575135097305 960 6810525 SGTC_2 0422-0095 29 µM -1.29377601063793 0.191341811524322 no 2763 0.0978714006273492 966 6790840 SGTC_1715 st032160 10.2275 µM -1.29400021600119 0.191298108480351 no 2764 0.0978326730989442 979 5289825 SGTC_2661 dactinomycin 12.96 µM -1.29502599860521 0.191098236701701 no 2765 0.0976556304743862 991 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_935 2996-0153 430 µM -1.29549558858818 0.191006780736607 no 2766 0.097574661087092 997 23738523 SGTC_2589 lobaric acid 100 µM -1.29572196897971 0.190962701148509 no 2767 0.097535644879186 997 73157 A novel microtubule depolymerizer. SGTC_1900 st060200 72.8 µM -1.29878371346486 0.190367147553458 no 2768 0.0970090827166062 984 688945 SGTC_2722 naftopidil 47.16 µM -1.30014150882809 0.190103402231428 no 2769 0.0967762366474713 998 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_822 1487-0950 154 µM -1.30259748509132 0.189626911242423 no 2770 0.096356108414318 970 1958375 SGTC_2833 9001315 45.46 µM -1.30289299816049 0.189569627466606 no 2771 0.0963056473542927 986 2989378 SGTC_2398 5228213 48.84 µM -1.30448381185646 0.189261438900809 no 2772 0.0960343377189018 1004 80771 YMR134W ERG29 SGTC_2937 9044753 11.33 µM -1.30529310648175 0.189104772583135 no 2773 0.0958965302475604 953 6465530 YGL099W LSG1 SGTC_1954 st077032 68.9 µM -1.30802588601238 0.188576341222288 no 2774 0.0954322647040181 1001 698907 SGTC_3197 9113331 49.47 µM -1.31082756662436 0.18803553280412 no 2775 0.0949580134469854 977 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1820 st053765 18.6 µM -1.31343512930469 0.187533056089627 no 2776 0.0945181833279922 986 3690829 SGTC_3253 9135987 49.47 µM -1.31360580551875 0.187500195781797 no 2777 0.0944894470106595 996 4182430 SGTC_886 0866-0150 153 µM -1.31485716502465 0.187259380115332 no 2778 0.09427895553433 1000 271463 SGTC_486 niguldipine 82 µM -1.31531196282508 0.187171904761354 no 2779 0.0942025396416838 998 1236 A calcium channel blocker. SGTC_1645 Cervolide 78 µM -1.31673683082449 0.186898010724058 no 2780 0.093963426728944 999 23173 A fragrance. SGTC_765 1319-0117 244 µM -1.3176220951746 0.186727966516591 no 2781 0.0938150926643965 962 3487746 YGL099W LSG1 SGTC_967 1306-0166 352 µM -1.31818400425219 0.186620083053651 no 2782 0.0937210294259577 999 4437607 SGTC_2222 6885208 172.143 µM -1.31823106966183 0.186611048504963 no 2783 0.0937131538663745 1008 609514 SGTC_87 0100-0052 35.5 µM -1.31943017542214 0.186380962757667 no 2784 0.0935126696015798 1027 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_191 3914-0123 66.505 µM -1.32108624531189 0.186063483328896 no 2785 0.0932363043907413 1018 3144412 SGTC_2518 prenyletin 46.28 µM -1.32254354858182 0.185784386237566 no 2786 0.0929936089921315 984 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1904 st060225 78 µM -1.32386647424013 0.185531249618249 no 2787 0.0927736971515915 973 66595 SGTC_3094 9117742 49.47 µM -1.32995146026923 0.184369670213778 no 2788 0.0917671323298308 1002 17149698 SGTC_1455 4262-0120 131 µM -1.3309683663349 0.184175992450907 no 2789 0.0915997099671933 984 1529587 SGTC_3002 9075603 71.4286 µM -1.33237282360847 0.183908710816782 no 2790 0.0913688538912268 975 20105405 SGTC_3295 9122362 53.5725 µM -1.33239941786911 0.183903652006435 no 2791 0.0913644866543888 1027 4730473 SGTC_3014 9081533 49.47 µM -1.33421005216366 0.183559433562942 no 2792 0.0910675130333905 1004 21367265 SGTC_331 k048-0133 24.5 µM -1.33450816366311 0.183502798312113 no 2793 0.0910186865952669 998 6813582 SGTC_762 1165-0429 115 µM -1.33467404861439 0.183471288190485 no 2794 0.0909915254018784 984 5967793 SGTC_2939 9044578 71.43 µM -1.33754842770948 0.182925830761138 no 2795 0.0905218428336834 1002 2653634 SGTC_1152 3909-8331 15.9 µM -1.3414850446827 0.182180441441585 no 2796 0.0898815110630679 982 16001939 SGTC_1272 0839-0021 27 µM -1.34509907535765 0.181497807107499 no 2797 0.0892966208940994 1016 5027250 SGTC_1494 4358-1428 177 µM -1.3459015138406 0.181346456414777 no 2798 0.089167140281216 991 1564571 SGTC_2517 totarol 10 µM -1.35448816368191 0.179731849254404 no 2799 0.0877903435427552 991 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2511 berberine 10.47 µM -1.35458275365892 0.179714113290654 no 2800 0.0877752656467318 998 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_292 k038-0015 474 µM -1.35571703851104 0.179501516429761 no 2801 0.087594608045053 1008 46368540 SGTC_780 0109-0199 192 µM -1.35585272188015 0.179476096143195 no 2802 0.0875730163414224 983 610414 SGTC_1279 0874-0590 65.2 µM -1.35664069228823 0.179328514578983 no 2803 0.0874477027334385 1005 3523074 SGTC_3121 9125696 49.47 µM -1.35793509360229 0.179086247595709 no 2804 0.0872421402846305 1032 1235365 SGTC_802 4112-3352 742 µM -1.35821329968735 0.179034203972381 no 2805 0.087198005825657 1000 704594 SGTC_204 PMA1.184 62.41 µM -1.35964695592041 0.17876616279922 no 2806 0.0869708356839419 1009 2252213 YGL008C PMA1 SGTC_3131 9127911 49.47 µM -1.36116463405685 0.178482688039584 no 2807 0.0867308338681627 993 45595681 SGTC_604 1000-0114 314 µM -1.36247741672754 0.178237712564533 no 2808 0.0865236332248896 1018 1572745 SGTC_6 0844-0013 19.835 µM -1.36260229819818 0.17821441975221 no 2809 0.0865039420789829 1027 1584900 SGTC_701 4424-0219 185 µM -1.36298652375758 0.178142766278407 no 2810 0.0864433789095492 1007 2911779 SGTC_2783 7738165 71.43 µM -1.36835756067862 0.177143033998987 no 2811 0.0856000907657623 1003 17201110 SGTC_3175 9106517 49.47 µM -1.37024034747112 0.176793424006691 no 2812 0.0853059436376548 1015 41468073 SGTC_2513 baicalein 25.65 µM -1.37060245780362 0.176726234683976 no 2813 0.0852494581916292 1029 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1880 MG-132 525 µM -1.37077465173077 0.176694289883832 no 2814 0.0852226075629307 981 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_795 0685-0265 78 µM -1.37444055546276 0.176015070945339 no 2815 0.0846524764748573 992 302754 SGTC_2456 5770359 74.46 µM -1.37539889042579 0.175837783490702 no 2816 0.0845039063981848 1006 3118787 SGTC_685 1278-0033 54.9 µM -1.3765558148879 0.175623908657942 no 2817 0.08432480983555 1004 3590572 SGTC_364 0083-0097 67.7 µM -1.37731066683403 0.175484451860199 no 2818 0.084208109368043 1032 5207356 SGTC_1888 azatryptophan 97.5 µM -1.38007555513938 0.174974246045171 no 2819 0.083781691437131 999 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_483 fpl-64176 144 µM -1.38161281533752 0.174690982432163 no 2820 0.083545308467384 1020 3423 SGTC_1483 3453-0561 55.9 µM -1.38210560071424 0.174600240875569 no 2821 0.0834696395269218 1005 4546991 SGTC_2104 5389443 200 µM -1.38439025855812 0.174179934865732 no 2822 0.0831194950711753 1022 2244536 SGTC_1091 telmisartan 47.6 µM -1.38907720484115 0.173319697128474 no 2823 0.0824046372815008 1017 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2238 6671620 73.2395 µM -1.38942681880302 0.173255637900444 no 2824 0.0823514999100216 989 729941 SGTC_2528 xanthyletin 44.79 µM -1.39302552780211 0.172597128469106 no 2825 0.0818060356486696 1015 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3040 9091894 49.47 µM -1.39336461305171 0.172535163361428 no 2826 0.0817547804644357 984 25236966 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.3934519205441 0.172519210914883 no 2827 0.0817415872261036 977 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2723 salbutamol 83.58 µM -1.39440499513688 0.172345130438082 no 2828 0.0815976702754222 999 9884233 β2-adrenoceptor agonist SGTC_675 1309-0189 238 µM -1.39730911958003 0.171815379081344 no 2829 0.0811603173122433 1005 4246530 SGTC_2810 7959871 45.46 µM -1.39734387233259 0.171809046015078 no 2830 0.08115509437686 992 2974535 SGTC_592 k241-0073 46.5 µM -1.39796008671074 0.171696776747671 no 2831 0.0810625266208828 1019 4230158 SGTC_1312 1218-2183 165 µM -1.39833989073554 0.171627602880408 no 2832 0.0810055121464775 1009 6744073 SGTC_2572 astragaloside iv 100 µM -1.40087091873629 0.171167080456752 no 2833 0.0806263382605213 999 45006101 An anti-inflammatory agent. SGTC_2993 9054257 71.4286 µM -1.40209912723111 0.17094389204437 no 2834 0.0804428238362246 992 6470217 YGL055W OLE1 SGTC_1251 0490-5699 265 µM -1.40260483782879 0.170852049125989 no 2835 0.0803673541929203 1013 3883818 SGTC_285 1486-1325 46 µM -1.4036057734777 0.170670360700961 no 2836 0.0802181374725519 999 22310230 SGTC_3265 9137266 49.47 µM -1.40869062310235 0.169749276989409 no 2837 0.0794633344050067 975 17224265 SGTC_320 4092-0846 5.34 µM -1.41572512242051 0.168480294666354 no 2838 0.078427999973346 1006 1359356 SGTC_1404 3909-7820 48.3 µM -1.41884093732308 0.167920174240942 no 2839 0.0779726973589746 964 23741373 SGTC_338 4055-0136 114 µM -1.4189048824616 0.167908691587493 no 2840 0.0779633743371618 1027 2900563 SGTC_1741 st038134 10.228 µM -1.42369486883049 0.167049989042405 no 2841 0.0772674098614398 1021 1272587 SGTC_656 4090-1979 187 µM -1.42532938909194 0.166757617191505 no 2842 0.0770310043023665 1012 22330961 SGTC_786 4544-0069 423 µM -1.42933856638618 0.166041881882865 no 2843 0.0764534731668782 992 748821 YLR208W SEC13 SGTC_1668 st014914 51.6 µM -1.43194883150203 0.16557695477595 no 2844 0.0760792328537994 1021 2839556 SGTC_987 1497-1013 404 µM -1.44176593441367 0.163835928507087 no 2845 0.0746842079994773 1018 1676435 SGTC_3206 9114350 49.47 µM -1.44503255240625 0.163259250123731 no 2846 0.0742243711570439 1006 17087243 SGTC_1138 3761-0006 1.03 µM -1.44679175102172 0.162949233824896 no 2847 0.0739776289033668 1017 12061087 SGTC_1637 st007924 17.4 µM -1.45157986152024 0.162107384752433 no 2848 0.0733092308316547 981 683336 SGTC_1850 st056238 17 µM -1.45255731935394 0.161935876147609 no 2849 0.0731733517928657 994 5393177 SGTC_2163 5671233 125 µM -1.45336949605387 0.161793458371837 no 2850 0.0730605955785758 984 701023 SGTC_3340 9146634 11.102 µM -1.45627979768209 0.161283798147579 no 2851 0.0726576439641167 1011 4907387 SGTC_365 0121-0052 13.6 µM -1.46054093267749 0.160539467421552 no 2852 0.0720707332179823 983 3101739 SGTC_3010 9080089 71.4286 µM -1.46150008917543 0.160372232836903 no 2853 0.0719391255487736 1011 17027233 SGTC_3328 9140624 29.0385 µM -1.46336706900028 0.160047040478793 no 2854 0.0716834822821672 1033 4904392 SGTC_584 0986-0246 15.4 µM -1.46523875710227 0.159721461140833 no 2855 0.0714278944403376 1032 53315 YDR232W HEM1 SGTC_1336 1486-0901 104 µM -1.46720502435943 0.159379896887646 no 2856 0.0711601452817993 1010 5006114 SGTC_1649 st011737 51.3 µM -1.46776971649657 0.15928189153895 no 2857 0.0710833930408884 966 1761035 SGTC_3098 9119039 49.47 µM -1.47163529150561 0.158612060269128 no 2858 0.0705596950383104 1009 17161528 SGTC_198 3454-2873 16.191 µM -1.47246908603988 0.158467821924822 no 2859 0.0704471245388109 1009 710957 SGTC_385 1494-0393 12.4 µM -1.47326559635096 0.158330113764155 no 2860 0.0703397167747987 1028 3090647 SGTC_1422 4031-0024 15.5 µM -1.47530035031461 0.157978683025611 no 2861 0.0700659061506501 1031 782427 SGTC_1708 st033234 31.827 µM -1.47624246671837 0.157816139811433 no 2862 0.0699394064776636 1010 674664 SGTC_1365 1672-3266 55.4 µM -1.47630525754857 0.157805310423645 no 2863 0.0699309816901426 989 6415873 SGTC_965 1291-5240 308 µM -1.47778968797804 0.157549436333239 no 2864 0.0697320396781228 1019 2834598 SGTC_3082 9117008 49.47 µM -1.47850669089195 0.157425942877521 no 2865 0.0696361037683654 1011 41448529 SGTC_559 1550-0661 158 µM -1.47919167696318 0.15730802330333 no 2866 0.0695445466941541 1017 5830875 SGTC_1825 st052143 62.6 µM -1.47958385196797 0.157240536968079 no 2867 0.0694921692744624 1026 674173 SGTC_2787 5284540 71.43 µM -1.47966241025055 0.157227020775306 no 2868 0.069481680978507 1028 736958 SGTC_1909 st060837 51.5 µM -1.48001896572085 0.157165683918567 no 2869 0.0694340926721222 995 678937 SGTC_332 4112-0506 40.9 µM -1.48165035284477 0.156885243437168 no 2870 0.0692166768212373 1027 2790355 SGTC_1950 st077106 7.18 µM -1.48324029304237 0.156612244808646 no 2871 0.0690052896877732 1000 13831864 SGTC_1392 3455-1037 33.9 µM -1.4846757949815 0.156366032600094 no 2872 0.0688148633041477 1000 981132 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.48513195057762 0.156287847812923 no 2873 0.0687544369285077 1032 4174840 SGTC_2961 9083290 32.55 µM -1.48603394242929 0.156133322785026 no 2874 0.0686350716154155 1021 17741490 SGTC_3127 9126946 49.47 µM -1.48623608476716 0.156098706517878 no 2875 0.0686083429948738 1003 27243249 SGTC_2713 st079149 53.4 µM -1.48872638860997 0.155672664441331 no 2876 0.0682797165852097 1019 3103253 SGTC_2347 9049783 174.81 µM -1.48948428506481 0.155543155597853 no 2877 0.0681799442525496 1021 6467988 YPL169C MEX67 SGTC_3349 9149703 23.001 µM -1.49013498701917 0.155432020802856 no 2878 0.0680943732198814 1030 4910494 SGTC_3332 9141069 11.198 µM -1.49135480134579 0.155223827276069 no 2879 0.0679341840693753 1004 17332883 SGTC_2711 st079103 59.1 µM -1.49160768652063 0.155180688790109 no 2880 0.0679010109844911 1014 54693780 SGTC_1995 st072814 61.1 µM -1.49233531895989 0.155056609564595 no 2881 0.0678056310676579 1025 5769371 SGTC_1821 st053465 65.6 µM -1.49319638774223 0.154909860814965 no 2882 0.0676928936985927 1032 675086 SGTC_1231 0242-0792 125 µM -1.495111770741 0.154583758295462 no 2883 0.0674426372141001 1023 3707635 SGTC_596 1155-0152 116 µM -1.50028486878058 0.153705284212187 no 2884 0.0667703136314795 1021 280313 SGTC_126 0417-1624 672.48 µM -1.50572806431979 0.152784518529402 no 2885 0.0660684982468915 1018 41912 YDL195W SEC31 SGTC_1987 st072290 61.9 µM -1.50628217333859 0.152690991564181 no 2886 0.0659973762103365 1029 54697379 SGTC_3274 9138298 49.47 µM -1.50836102933824 0.152340444149488 no 2887 0.0657310756725917 1031 17015756 SGTC_1015 4130-4525 82 µM -1.50962748082393 0.1521271506267 no 2888 0.0655692525530407 1016 1363237 SGTC_353 1988-1175 58.3 µM -1.50977482340433 0.152102348333876 no 2889 0.06555044566782 993 2788357 SGTC_143 4032-1194 15.74 µM -1.51100473624144 0.151895420902117 no 2890 0.0653936220867989 1021 1806963 SGTC_716 1683-5115 658 µM -1.51294401899314 0.15156952520491 no 2891 0.0651469396379966 1015 723597 SGTC_2442 5158906 48.48 µM -1.51414241837746 0.151368367204762 no 2892 0.0649948610968242 1019 1893835 SGTC_731 3966-0296 387 µM -1.51655640961186 0.150963704597383 no 2893 0.0646893590040868 1024 660956 SGTC_33 0986-0033 35.816 µM -1.51916966903774 0.150526450550101 no 2894 0.0643598969193926 988 2848082 SGTC_2391 6285546 200 µM -1.52457055664927 0.149625442714186 no 2895 0.063683122955767 1032 846083 SGTC_153 4077-0274 519.67 µM -1.52570687335442 0.149436334842046 no 2896 0.0635414409942165 1003 3121976 SGTC_1560 lithocholic acid 53.1 µM -1.52762814861866 0.149116955814571 no 2897 0.0633024444071974 1002 9903 A bile acid which acts as a detergent. SGTC_1610 st001799 48.1 µM -1.52796603374493 0.14906083538698 no 2898 0.0632604857210154 1028 621897 SGTC_441 propafenone 146 µM -1.52803711018574 0.14904903186855 no 2899 0.0632516621823906 1021 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1403 3909-7815 62.9 µM -1.53736755769506 0.147504963419208 no 2900 0.0621016631318278 1017 6615483 SGTC_2823 7987624 58.44 µM -1.53803300690425 0.147395251070201 no 2901 0.0620202722924731 1031 2239440 SGTC_13 0199-0087 65 µM -1.53826234747713 0.147357452453858 no 2902 0.0619922410287755 1032 4589825 SGTC_1096 rimcazole 32.2 µM -1.53892233120902 0.14724871391454 no 2903 0.0619116293542434 1024 18528119 A dopamine reuptake inhibitor. SGTC_1557 sumaresinolic acid 42.3 µM -1.53932628988874 0.147182184456717 no 2904 0.061862329444551 1021 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3041 9091929 49.47 µM -1.53946285268012 0.147159697980849 no 2905 0.0618456699855425 1015 25236887 SGTC_517 1365-0151 113 µM -1.54326402329874 0.146534720154634 no 2906 0.0613833644398018 1023 768657 SGTC_3316 9136639 10.545 µM -1.54412149134125 0.146393984289087 no 2907 0.0612794516742078 1003 4903665 SGTC_2286 7945697 125 µM -1.54663968883385 0.145981198339898 no 2908 0.0609750768569854 1014 1245733 SGTC_1675 st018485 24.5 µM -1.54716281118212 0.145895545698787 no 2909 0.0609119955099507 1035 3323024 SGTC_1372 2752-0194 270 µM -1.55034057303072 0.14537596548737 no 2910 0.0605298969597475 1018 823334 SGTC_1042 0350-0096 82 µM -1.55062548100862 0.14532944246206 no 2911 0.0604957310311869 1025 3122515 SGTC_1393 3470-5649 58.2 µM -1.55180474493307 0.145136985327453 no 2912 0.0603544751345996 1026 4108395 SGTC_3135 9127742 49.47 µM -1.55208726843225 0.145090902670241 no 2913 0.0603206719506515 1014 3643468 SGTC_182 3448-4371 550.524 µM -1.55257651687518 0.14501112421994 no 2914 0.0602621697277344 1020 3491403 SGTC_754 3474-0146 171 µM -1.55333194480729 0.144887999678173 no 2915 0.0601719261471896 1013 24762078 SGTC_2032 5185112 25.99 µM -1.55359547605027 0.144845064212883 no 2916 0.0601404695524377 1014 5718189 SGTC_1812 st052057 4.327 µM -1.5565499881653 0.144364290848159 no 2917 0.0597886827937396 1029 3645418 SGTC_782 0083-0095 30.5 µM -1.55698897743203 0.144292948142305 no 2918 0.0597365512177437 1035 3591729 An indicator and reagent. SGTC_75 0159-0059 199.013 µM -1.55730441172535 0.14424169975127 no 2919 0.0596991142388386 1029 5377270 SGTC_3355 9151058 44.0485 µM -1.56497725281684 0.14299887754266 no 2920 0.0587941215319814 1042 17015728 SGTC_1396 3511-0007 98.6 µM -1.56659646350157 0.142737530358481 no 2921 0.0586045225044736 1018 X1396 SGTC_1013 4112-3890 241 µM -1.57043392649829 0.142119438373598 no 2922 0.0581570974025921 1020 705171 SGTC_175 3793-3120 23.7 µM -1.57200977040895 0.14186614601609 no 2923 0.0579741426636098 1033 5322297 SGTC_2146 5545642 200 µM -1.57211013299722 0.141850024654286 no 2924 0.0579625059538853 1029 825326 SGTC_2175 5807670 165.306 µM -1.5741556947034 0.14152171395605 no 2925 0.0577257296463652 999 241186 SGTC_245 methotrexate 289.6 µM -1.57526138342562 0.141344466510135 no 2926 0.0575980618245679 1022 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.57875465322802 0.140785466807609 no 2927 0.0571961717677885 1034 688751 SGTC_496 calpeptin 138 µM -1.58187389094959 0.140287589794313 no 2928 0.0568391811839951 1021 73364 A calpain inhibitor. SGTC_3153 9100258 49.47 µM -1.58884350435635 0.139179460429437 no 2929 0.0560478643259827 1019 25236848 SGTC_2789 5281112 71.43 µM -1.59394549823879 0.138372058374126 no 2930 0.0554741213039608 1018 765948 SGTC_11 0438-0307 1.3 µM -1.59537267750708 0.138146776588638 no 2931 0.055314461068329 1033 4011476 SGTC_3102 9121669 49.47 µM -1.59707271441885 0.137878750484203 no 2932 0.0551247497673125 1059 41905072 SGTC_1444 4112-3581 28 µM -1.59873602090237 0.137616858817934 no 2933 0.0549396351438448 1035 2877249 SGTC_2705 st078069 42.8 µM -1.59980359314486 0.137448945970901 no 2934 0.0548210807351604 1034 1530061 SGTC_2859 9028643 45.46 µM -1.59981059298593 0.137447845464353 no 2935 0.0548203040672786 995 17151580 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.60030618950972 0.137369943669452 no 2936 0.0547653372219835 1003 4330530 SGTC_539 4859-0462 2.54 µM -1.60653431920343 0.136393526853597 no 2937 0.0540782803260051 1011 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_865 0488-0499 301 µM -1.6065532394501 0.13639056787834 no 2938 0.0540762035792477 1019 9634651 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.60839633468423 0.136102533010695 no 2939 0.0538742019576199 1047 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_223 busulfan 5 mM -1.6093513477406 0.135953449546307 no 2940 0.053769768612654 1032 2478 A DNA alkylator. SGTC_3348 9149464 3.537 µM -1.6108541767424 0.135719075087145 no 2941 0.0536057547789393 1023 1951442 SGTC_448 monastrol 171 µM -1.61517495639876 0.135046768025855 no 2942 0.0531364061405169 1043 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3035 9091303 49.47 µM -1.61782751907934 0.134635166443932 no 2943 0.0528498870077794 1050 25237002 SGTC_1862 st057513 3.81 µM -1.62568804849157 0.133420497657394 no 2944 0.0520080168905901 1032 5393163 SGTC_1269 0831-0796 3.05 µM -1.6264626933325 0.133301202981432 no 2945 0.0519256317072829 991 927758 SGTC_1716 st033144 30.6155 µM -1.63165920642855 0.13250284166757 no 2946 0.0513756490972533 1037 674617 SGTC_861 0443-0273 110 µM -1.63472638436462 0.132033167961593 no 2947 0.0510532094605698 1029 6149169 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.63516336029826 0.131966347851394 no 2948 0.0510074033622131 993 688669 SGTC_1179 1021-1431 9.29 µM -1.63663889644086 0.131740888825618 no 2949 0.0508529716421696 1047 2840958 SGTC_1192 1488-0095 21.4 µM -1.63694546033941 0.131694079829221 no 2950 0.0508209329799602 1045 915875 SGTC_502 l-744,832 89.3 µM -1.64050802456658 0.131150956327466 no 2951 0.0504497906814629 1045 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1405 3909-7894 12 µM -1.64113392520383 0.131055695935588 no 2952 0.0503848089360481 996 7104060 SGTC_2120 5538279 151.968 µM -1.64129126760729 0.131031756366014 no 2953 0.0503684839565451 1040 2058197 SGTC_1060 3448-7350 82 µM -1.64304490106274 0.13076514637239 no 2954 0.0501868217689367 1021 570178 SGTC_508 roscovitine 141 µM -1.64331563507255 0.130724019330881 no 2955 0.0501588225223957 1056 160355 A CDKinase inhibitor. SGTC_2882 9058044 58.44 µM -1.64412803446405 0.130600661901428 no 2956 0.0500748791142506 1026 18076804 SGTC_2665 lovastatin 100 µM -1.6464912782583 0.130242276799241 no 2957 0.0498313271379599 1044 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2328 6201408 200 µM -1.64797275139581 0.130017959201106 no 2958 0.0496791314363899 1033 2890418 SGTC_309 k408-0051 1.48 µM -1.6529632805102 0.129264285423163 no 2959 0.0491691684547294 1018 3640463 SGTC_730 1436-0052 41.2 µM -1.65298182336749 0.129261490724048 no 2960 0.0491672814571167 1037 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2701 st077767 14.721 µM -1.65476906130678 0.128992322495152 no 2961 0.0489856760274446 1034 5721188 SGTC_14 0354-0009 295 µM -1.65671981647793 0.12869897158144 no 2962 0.0487880673372011 1061 1713507 SGTC_1438 4092-1045 4 µM -1.65688004558212 0.128674897216381 no 2963 0.0487718647139998 1034 1351342 SGTC_2558 carylophyllene oxide 100 µM -1.66204037468961 0.127901230074509 no 2964 0.0482523397022646 1052 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3185 9108267 49.47 µM -1.66394931202238 0.12761585154818 no 2965 0.0480612796465809 1046 4910486 SGTC_1521 st012942 49.4 µM -1.67031816632943 0.126666936698041 no 2966 0.0474282154099491 1030 24207259 SGTC_1051 3253-3903 78 µM -1.67065566031279 0.126616789906435 no 2967 0.0473948557996888 1034 5509239 SGTC_5 0352-0601 109.883 µM -1.67229212229393 0.126373831077775 no 2968 0.0472333661512645 1022 762456 SGTC_3319 9138450 16.7555 µM -1.67258110834631 0.126330960268487 no 2969 0.047204894247101 1025 2029690 SGTC_870 0573-2213 57.6 µM -1.67259843420639 0.126328390315479 no 2970 0.0472031876807278 1038 3916321 SGTC_1607 st000305 50.6 µM -1.67395181984029 0.126127754546577 no 2971 0.0470700343418885 1039 5457690 SGTC_1885 st057546 99.9 µM -1.67914740798433 0.125359586311505 no 2972 0.0465616593693691 1018 702008 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.68144150799495 0.125021444895387 no 2973 0.046338594409877 1020 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2221 6807166 181.081 µM -1.68345004448262 0.124725917941828 no 2974 0.0461440011565362 1049 674925 SGTC_753 1322-0200 289 µM -1.68599040642376 0.124352840303326 no 2975 0.0458988235951391 1054 5403907 SGTC_2307 7538926 6.34 µM -1.68648526119823 0.12428025682861 no 2976 0.0458511857836873 1022 96582 SGTC_2415 st077333 57.7 µM -1.68890118426841 0.123926323628794 no 2977 0.0456191841470765 1023 2766255 SGTC_3283 9109332 35.8195 µM -1.68960123455138 0.123823898077965 no 2978 0.0455521348017533 1016 17027281 SGTC_616 4092-0450 108 µM -1.69234129045128 0.123423565790077 no 2979 0.0452904596792837 1055 787165 SGTC_25 0118-0223 35.662 µM -1.70132979490145 0.122116681044279 no 2980 0.0444405380705845 1047 5333628 SGTC_1164 k060-0068 93.7 µM -1.70139195135678 0.122107677756178 no 2981 0.0444347058271422 1045 5963676 SGTC_1224 0823-0416 294 µM -1.7033647743454 0.121822158852612 no 2982 0.0442499127837383 1035 3598164 SGTC_2340 7987427 183.45 µM -1.70646058836281 0.121375059956135 no 2983 0.0439611790971119 1037 2239331 SGTC_482 fipronil 114 µM -1.70717170248915 0.121272523674896 no 2984 0.0438950714941651 1059 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_856 0433-0016 11.3 µM -1.72211147636477 0.119132413863819 no 2985 0.0425246632797601 1053 3911780 SGTC_884 0851-0618 334 µM -1.72238730406149 0.119093154047744 no 2986 0.0424996910006135 1035 9642473 SGTC_799 1310-0557 151 µM -1.72569329824062 0.118623307528543 no 2987 0.0422013021801564 1044 5354492 SGTC_3238 9133470 49.47 µM -1.72608874806215 0.118567194190856 no 2988 0.0421657238953845 1035 3534688 SGTC_2171 5739187 198.077 µM -1.72837483068057 0.118243172448566 no 2989 0.0419605224706724 1038 2262761 SGTC_1790 st045711 43.5 µM -1.72882244159385 0.118179802933668 no 2990 0.0419204391935128 1026 585119 SGTC_2339 9000433 200 µM -1.7292720622633 0.11811617307365 no 2991 0.0418802071590955 1028 2988954 SGTC_3171 9103192 49.47 µM -1.73571368349361 0.117207220687385 no 2992 0.041307236401658 1063 13018434 SGTC_1786 berberine 21.6 µM -1.73730082471776 0.11698402814167 no 2993 0.0411670430348333 996 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.73907172661718 0.116735349870679 no 2994 0.0410110735762228 1056 2374 Ca(2+)-ATPase inhibitor. SGTC_350 k064-0020 19.8 µM -1.7437129137141 0.11608539174045 no 2995 0.0406045812151137 997 2790705 SGTC_2164 5685496 200 µM -1.74590105437357 0.115779854174273 no 2996 0.0404140733239556 1050 759046 SGTC_2954 9074818 52.69 µM -1.75201177174286 0.114929619605462 no 2997 0.0398858918860797 1056 16648742 SGTC_3333 9141820 12.094 µM -1.75369062823898 0.114696806054438 no 2998 0.039741766129347 1033 1939433 SGTC_2079 5212404 121 µM -1.75447468933776 0.114588192290955 no 2999 0.0396746015858005 1042 758462 SGTC_2834 9001755 58.44 µM -1.75483749894984 0.114537958083563 no 3000 0.0396435537009314 1029 2989575 SGTC_1400 3771-8998 51.5 µM -1.75781171801952 0.114126741957218 no 3001 0.0393897754251192 1072 670767 SGTC_1070 indatraline 8.81 µM -1.75806805018397 0.114091350704189 no 3002 0.0393679656280594 1046 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_809 3998-0021 90 µM -1.75920744542487 0.113934131362284 no 3003 0.0392711400567138 1041 715485 SGTC_1794 st048918 76.9 µM -1.75955716309956 0.113885906579164 no 3004 0.039241460021153 1003 672303 SGTC_538 2922-0838 53.3 µM -1.7599258532137 0.113835081318647 no 3005 0.039210189592389 1053 777039 SGTC_422 cantharidin 155 µM -1.76288268728518 0.113428055684938 no 3006 0.0389601387827999 1040 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1671 st016596 74.5 µM -1.76479118245381 0.113165891858872 no 3007 0.0387994335617779 1064 2829167 SGTC_3026 9090633 49.47 µM -1.76800616387196 0.112725238336867 no 3008 0.0385299366043661 1043 25236842 SGTC_2015 5119600 184 µM -1.76824763781665 0.112692190841535 no 3009 0.0385097567120043 1046 2828786 SGTC_617 3770-0098 35 µM -1.77181025726118 0.112205423857924 no 3010 0.0382130296569932 1044 5962639 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.77400249344125 0.111906642630509 no 3011 0.0380313689360466 1054 689007 SGTC_393 acivicin 6.25 µM -1.77629328535592 0.111595037505413 no 3012 0.0378422946901079 999 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1330 1469-0054 61.8 µM -1.77728539108424 0.111460279084283 no 3013 0.0377606480179141 1042 7102664 SGTC_564 3555-0129 330 µM -1.78045614733457 0.111030374010867 no 3014 0.0375006699768814 1034 563260 SGTC_3008 9078912 71.4286 µM -1.78198889145218 0.110822984151267 no 3015 0.0373755216315237 1053 16648731 SGTC_2566 crystal violet carbinol 226 nM -1.78356253001113 0.110610349919932 no 3016 0.0372473893929357 1041 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1283 0922-0125 16.4 µM -1.78619773784739 0.110254928751577 no 3017 0.0370336236222443 1034 3360884 SGTC_3203 9113543 49.47 µM -1.79246890334249 0.10941240698323 no 3018 0.0365289430447906 1036 17018012 SGTC_35 0133-0054 64.071 µM -1.79605909141524 0.108932157081712 no 3019 0.0362425598142887 1038 99677 SGTC_830 4076-0286 57.8 µM -1.79749232243539 0.108740861420703 no 3020 0.036128747944955 1052 6866659 SGTC_1081 sertraline 6 µM -1.79817080966472 0.108650386930606 no 3021 0.0360749719059204 1039 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3137 9097352 49.47 µM -1.80031981874251 0.108364179560079 no 3022 0.0359050766394187 1027 44120435 SGTC_3038 9091290 49.47 µM -1.80183742805154 0.108162389800736 no 3023 0.035785493586802 1045 25236843 SGTC_2218 6965428 192.983 µM -1.80314621263195 0.107988583876205 no 3024 0.035682627560051 1037 675684 SGTC_1612 st002233 45.4 µM -1.80486258930624 0.107760954857692 no 3025 0.0355480936122389 1040 1035021 SGTC_3184 9108758 49.47 µM -1.8109228268901 0.10696000014747 no 3026 0.0350763992681563 1067 902885 SGTC_2827 7993847 71.43 µM -1.81443213623835 0.106498158347446 no 3027 0.0348056109657016 1035 2985692 SGTC_1733 st037357 54.9 µM -1.81451348628896 0.106487469394664 no 3028 0.0347993541765913 1038 1272339 YGL099W LSG1 SGTC_918 glabranin 770.725 nM -1.81804264162557 0.106024503051106 no 3029 0.0345288078092987 1067 124049 Also referred to as licorice root. SGTC_3255 9139072 49.47 µM -1.81892409751628 0.105909098059912 no 3030 0.0344615054279265 1058 17646060 SGTC_2085 5307070 144.047 µM -1.81925748753711 0.105865472498572 no 3031 0.0344360779890897 1055 2840351 SGTC_1492 4158-0558 28.5 µM -1.82056658861177 0.105694296452017 no 3032 0.0343363827725951 1042 3967268 SGTC_2190 6049624 200 µM -1.82069208942898 0.105677896675289 no 3033 0.034326837670594 1048 2265554 SGTC_1989 st071868 50.2 µM -1.82124494155186 0.105605674814656 no 3034 0.0342848158556886 1051 16414057 SGTC_610 4215-0184 155 µM -1.82398758908402 0.105247916618048 no 3035 0.0340769742757266 1021 5605015 SGTC_704 1310-0270 142 µM -1.82895017937306 0.104602813638701 no 3036 0.0337035360154654 1052 5718033 SGTC_2726 cimetidine 79.27 µM -1.82902720219487 0.104592823818375 no 3037 0.0336977666424207 1063 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1663 st014140 55.4 µM -1.83099181894643 0.104338247624712 no 3038 0.0335508820918309 1044 4207120 SGTC_1426 4048-4480 71.7 µM -1.8325871493362 0.104131854382641 no 3039 0.0334319953257977 1054 14224343 SGTC_2824 7998404 51.95 µM -1.83405625335379 0.103942053396929 no 3040 0.0333228221455624 1052 837851 SGTC_1628 st004252 77.7 µM -1.84001879981266 0.103174297321835 no 3041 0.0328827386487084 1044 692968 SGTC_2178 5812956 200 µM -1.84242304735155 0.102865886804621 no 3042 0.0327066465656035 1048 5403383 SGTC_2059 5238311 157 µM -1.84481154102924 0.102560160965128 no 3043 0.0325324789995405 1045 703021 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.84565702478304 0.102452097976769 no 3044 0.0324710104464438 1074 6708784 An antioxidant flavonoid SGTC_1889 st059080 5.18 µM -1.85591194101432 0.101147982975406 no 3045 0.031733055337192 1055 176925 Isolated from Daphnopsis sellowiana. SGTC_396 dithiazanine 1.25 µM -1.85784373423778 0.100903677473061 no 3046 0.0315956042427079 1057 10578 An antihelmenthic. SGTC_2014 4013930 200 µM -1.85949099648611 0.100695695434993 no 3047 0.0314787871382236 1055 64556 SGTC_1166 k206-0078 225 µM -1.86034679292935 0.100587766742716 no 3048 0.0314182386233571 1048 5404595 SGTC_74 000s-0487 160.283 µM -1.86080486576706 0.100530031612553 no 3049 0.0313858690630108 1041 677548 SGTC_1215 3852-0577 11.2 µM -1.86128028999722 0.10047013509848 no 3050 0.0313523025385933 1047 2884876 SGTC_1441 4106-0040 13 µM -1.86246778524035 0.100320641781096 no 3051 0.0312685910961584 1061 2904180 SGTC_1077 5-fluorocytosine 377 nM -1.86582553562696 0.0998988145012102 no 3052 0.031032889225947 1054 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3200 9114385 49.47 µM -1.86683824941953 0.0997718439857483 no 3053 0.0309620896411506 1039 17018030 YLR208W SEC13 SGTC_1664 st014217 9.02 µM -1.86970197464105 0.0994134382362583 no 3054 0.0307626075839763 1030 3982782 SGTC_206 4546-0025 72.014 µM -1.87275420856879 0.0990324770049976 no 3055 0.0305511669667976 1053 6620745 YIL048W NEO1 SGTC_1454 4239-0054 42.6 µM -1.87359757170477 0.098927402098755 no 3056 0.0304929564979896 1050 1340767 SGTC_901 1112-0062 60.1 µM -1.87400160604006 0.098877092227854 no 3057 0.0304651018764399 1054 1908457 SGTC_3339 9145883 14.936 µM -1.87997224322191 0.0981358167716349 no 3058 0.0300559304563935 1021 2030670 SGTC_84 0443-0269 128.823 µM -1.885713124031 0.0974269135826188 no 3059 0.0296668116916797 1047 6150058 SGTC_1380 2291-0730 164 µM -1.88591667816693 0.0974018471720133 no 3060 0.0296530918299487 1053 2999191 SGTC_2369 9071472 200 µM -1.88639313972335 0.0973431924277642 no 3061 0.0296209981744857 1056 17296037 SGTC_2352 9027995 87.8 µM -1.89145791719116 0.0967212946888218 no 3062 0.0292816217574854 1051 2997347 SGTC_943 3253-1379 105 µM -1.8958758682511 0.0961812069984451 no 3063 0.0289882303069315 1038 668464 SGTC_1553 gossypol 38.6 µM -1.89726590485237 0.096011736535592 no 3064 0.0288964262518507 1054 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3057 9095946 49.47 µM -1.89891950341796 0.0958104192256081 no 3065 0.0287875302900525 1073 24540043 SGTC_2860 9025725 38.96 µM -1.90117013079216 0.095536915812797 no 3066 0.0286398660344508 1068 40546248 SGTC_989 1501-0895 10.3 µM -1.90585942172546 0.0949689048346744 no 3067 0.0283342234844926 1048 2830112 SGTC_2275 7947463 200 µM -1.90785930690049 0.0947274181542041 no 3068 0.0282047014996482 1032 1225414 SGTC_2467 5474540 200 µM -1.90867847895727 0.0946286336605804 no 3069 0.0281517905343913 1042 5413519 SGTC_690 glyoxal 20.3 µM -1.91391141252161 0.0939993821043454 no 3070 0.0278157379597604 1054 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1901 st060216 58.6 µM -1.9237495576946 0.0928247303291718 no 3071 0.0271929914554354 1044 688792 SGTC_106 0092-0003 11.579 µM -1.93233496807315 0.0918085515965649 no 3072 0.0266590875328178 1052 1072148 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.94439247340978 0.0903953576970142 no 3073 0.0259240704016486 1056 23665772 A membrane-active detergent. SGTC_1127 asiatic acid 681.4 nM -1.94534005540416 0.0902849852282064 no 3074 0.0258670321201009 1050 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_88 0180-0332 8.668 µM -1.94720937200476 0.0900675444792062 no 3075 0.025754819279439 1058 3101745 SGTC_3046 9092212 49.47 µM -1.94998798275989 0.0897450531053131 no 3076 0.0255887756939219 1073 25236637 SGTC_3118 9124250 49.47 µM -1.9505278831036 0.0896824908667781 no 3077 0.0255566166706738 1047 1504786 SGTC_3155 9099265 49.47 µM -1.95274367751104 0.0894260700065803 no 3078 0.0254249876917727 1055 25236499 SGTC_1388 3346-4487 254 µM -1.95984836762031 0.0886075636474486 no 3079 0.0250067580045997 1072 3345614 SGTC_986 1493-0483 84 µM -1.96536841464061 0.0879754805402379 no 3080 0.0246858062237358 1062 40079 SGTC_144 4161-2749 112.381 µM -1.969850628804 0.0874647147619473 no 3081 0.0244277460751704 1058 797501 YMR168C CEP3 SGTC_992 3909-8734 162 µM -1.97007786530939 0.087438879347002 no 3082 0.0244147236451778 1072 4288319 SGTC_847 0342-0274 5.54 µM -1.97124498400798 0.0873062747672013 no 3083 0.02434793041406 1060 18097 SGTC_490 phenamil 164 µM -1.97243214736509 0.0871715468541029 no 3084 0.0242801475121585 992 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_818 4072-2707 53.5 µM -1.97403457720225 0.0869899377773703 no 3085 0.0241889057026297 1047 882871 SGTC_2394 5221648 200 µM -1.98148941582292 0.0861487688804221 no 3086 0.0237682075787053 1072 788586 SGTC_2926 9010726 65.15 µM -1.98406922756664 0.0858590967337632 no 3087 0.0236240615220112 1061 2994293 SGTC_2835 9006588 71.43 µM -1.98497093787639 0.0857580210145815 no 3088 0.0235738524920061 1030 2345538 SGTC_171 k064-0041 9.68 µM -1.98821510230207 0.085395108454472 no 3089 0.0233939527071153 1035 53325 SGTC_941 3237-0776 460 µM -1.99028120301835 0.0851645818350038 no 3090 0.0232799837296081 1066 760008 SGTC_3141 9094609 49.47 µM -1.99360213811477 0.0847950238337987 no 3091 0.0230977757647261 1050 25236309 YDL196W YDL196W SGTC_2068 5226020 147 µM -1.99619258281173 0.0845075915502285 no 3092 0.0229564822490553 1066 1810509 SGTC_100 0086-0128 49.5915 µM -1.99928482098338 0.0841654386949152 no 3093 0.0227887727797474 1061 93297 SGTC_2482 5981709 142.65 µM -1.99981322045964 0.0841070760308851 no 3094 0.0227602182398252 1051 877755 SGTC_1629 st005085 44.9 µM -2.00428978269732 0.0836138502142721 no 3095 0.0225195138591655 1051 24207091 SGTC_297 0986-0032 24 µM -2.00608898618533 0.0834162281135599 no 3096 0.0224233773665458 1054 2847425 SGTC_826 1683-5028 118 µM -2.00992026860795 0.0829965752409558 no 3097 0.0222198140912318 1069 722377 SGTC_2877 9040724 71.43 µM -2.01086369100941 0.0828934831779024 no 3098 0.0221699282240729 1072 6463895 SGTC_1796 st049173 110.4 µM -2.01419280084453 0.0825304658853578 no 3099 0.0219946476210693 1058 94134 SGTC_2603 homopterocarpin 100 µM -2.01602763296152 0.0823309018738877 no 3100 0.0218985431759621 1057 101795 A weak amylase inhibitor. SGTC_2888 9058547 12.99 µM -2.02160954934175 0.0817260236076359 no 3101 0.0216083523748711 1059 16476514 SGTC_180 1486-1293 102.781 µM -2.02426920559452 0.0814389939384318 no 3102 0.0214712301499365 1052 4140536 SGTC_2428 5615643 7.78 µM -2.02565245366274 0.0812900148897485 no 3103 0.0214002061236327 1047 2253075 SGTC_310 1273-0058 1.06 µM -2.02611395456306 0.0812403559323767 no 3104 0.0213765542077669 1002 2734232 SGTC_2426 5582046 32.21 µM -2.02797908433587 0.0810398952109051 no 3105 0.0212811913630372 1067 2251934 SGTC_3303 9125618 40.5795 µM -2.02859648527503 0.0809736204003813 no 3106 0.0212497034272852 1052 22695467 SGTC_942 3253-1115 227 µM -2.03447082835905 0.0803450850066782 no 3107 0.0209520734640082 1059 46497897 SGTC_2056 5235370 200 µM -2.03502159856688 0.0802863439623509 no 3108 0.0209243498897814 1052 5511916 SGTC_1928 4'-methoxychalcone 40.3 µM -2.03690001452081 0.080086250209475 no 3109 0.0208300313429561 1059 641818 SGTC_1979 st071809 45.3 µM -2.03762589621775 0.0800090284741322 no 3110 0.0207936800995102 1073 4976333 SGTC_447 ml7 120 µM -2.04081624388887 0.0796702959225793 no 3111 0.0206345476776248 1086 4216 Selective myosin light chain kinase inhibitor. SGTC_3248 9135562 49.47 µM -2.04094475656064 0.0796566739614648 no 3112 0.0206281592231472 1067 17650701 SGTC_321 4534-3890 65.3 µM -2.05017683981764 0.0786827037720966 no 3113 0.020173588597878 1060 699746 SGTC_1352 1496-0991 99 µM -2.05122445418446 0.0785727547510777 no 3114 0.0201225467487114 1069 3000039 SGTC_3326 9140064 16.379 µM -2.05511915920852 0.0781650195195966 no 3115 0.0199337484035424 1066 1868434 SGTC_657 3534-0529 86.7 µM -2.05712869374126 0.0779552707437444 no 3116 0.0198369241411092 1083 1049549 SGTC_2658 polymyxin b sulfate 77.05 µM -2.05837795919793 0.0778250918628944 no 3117 0.0197769329147771 1072 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1225 1216-0074 20.6 µM -2.05928827922811 0.0777303365292714 no 3118 0.0197333153081118 1073 4241466 SGTC_3032 9089427 49.47 µM -2.06068046104506 0.0775855935512147 no 3119 0.0196667674490386 1023 17173707 SGTC_997 3996-0078 137 µM -2.06148659589868 0.077501874573633 no 3120 0.0196283204770946 1063 735687 SGTC_3105 9121040 49.47 µM -2.06814904507796 0.0768125881625751 no 3121 0.0193130050078726 1051 41448907 SGTC_2080 5212524 12.4 µM -2.06990916686703 0.0766312694094338 no 3122 0.0192304256740314 1062 260183 SGTC_1718 roemerine 11.9335 µM -2.07589057267922 0.0760175278387838 no 3123 0.0189520364136608 1012 235224 An aporphine alkaloid with mutagenic activity. SGTC_2606 farnesol 9.78 µM -2.0765756321374 0.0759474746248479 no 3124 0.0189203719440907 1050 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_499 genistein 192 µM -2.08041123970806 0.0755561585975624 no 3125 0.0187439146037282 1083 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1369 1866-0067 208 µM -2.08135647458398 0.0754599602876458 no 3126 0.0187006447480061 1050 3531355 SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.0831533451307 0.075277346845867 no 3127 0.0186186241011595 1059 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1734 st037168 69.4 µM -2.08554343944315 0.0750349672380383 no 3128 0.0185099996796416 1063 708907 SGTC_937 3122-0005 46.7 µM -2.08736209154443 0.0748509367137287 no 3129 0.0184277079790205 1069 759535 SGTC_2650 prasterone 100 µM -2.0914537278622 0.0744381605548231 no 3130 0.0182437051091371 1072 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1270 0831-1170 17.3 µM -2.10521575459097 0.0730625544238988 no 3131 0.0176362657379692 1067 6764716 SGTC_3188 9110789 49.47 µM -2.10720288187127 0.0728655456455565 no 3132 0.0175499986219306 1060 849217 SGTC_101 0490-5701 117.494 µM -2.10960972915183 0.0726274696734105 no 3133 0.0174459928172755 1064 4661669 SGTC_1264 0783-0040 158 µM -2.11155126311773 0.0724358551730276 no 3134 0.01736247828652 1065 2855798 SGTC_2058 5236698 133 µM -2.11314833408313 0.0722785270544903 no 3135 0.0172940369085488 1068 766665 SGTC_156 3474-0145 5.642 µM -2.11376495807238 0.0722178532905514 no 3136 0.0172676736466909 1062 2265471 SGTC_3343 9148379 18.9835 µM -2.1146247355307 0.0721333191976394 no 3137 0.0172309718674373 1042 1955036 SGTC_2457 5731572 11.68 µM -2.11905726060175 0.0716987123689892 no 3138 0.0170428140424907 1075 2865357 SGTC_1360 1598-0022 39.8 µM -2.12194723943259 0.0714164350247105 no 3139 0.0169210844361513 1079 761525 SGTC_3329 9141233 27.5565 µM -2.12257903036939 0.0713548389028935 no 3140 0.0168945718475591 1047 4909101 YNL103W MET4 SGTC_1178 0988-0033 191 µM -2.13169342795847 0.0704707667393246 no 3141 0.0165160287263026 1065 5392207 SGTC_1705 st027868 56.3335 µM -2.13445178678361 0.0702048799144809 no 3142 0.0164029081415617 1054 292948 SGTC_919 tnp00227 403.569 nM -2.13485315551472 0.0701662551178606 no 3143 0.0163865033831776 1069 1269246 A methoxyflavone. YNL221C POP1 SGTC_1407 3909-7909 12.3 µM -2.13698904311576 0.0699609877572585 no 3144 0.0162994414056752 1044 4411780 SGTC_1345 1488-0192 31.4 µM -2.14029611699802 0.0696440766697802 no 3145 0.0161654217991431 1073 658348 SGTC_3068 9116768 49.47 µM -2.15938548867606 0.0678363347169222 no 3146 0.0154101363768064 1064 41904888 SGTC_2689 tacrolimus 100 µM -2.16406547430303 0.0673987254771307 no 3147 0.015229662397595 1034 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2784 7567673 72.73 µM -2.18077133056855 0.0658543984241735 no 3148 0.0146001670448857 1059 3471247 SGTC_392 N-ethylmaleimide 8.33 µM -2.19034952228631 0.0649814203020761 no 3149 0.0142494489291713 1066 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_418 lividomycin a 100 µM -2.19280524135718 0.0647590536616594 no 3150 0.0141607070776735 1074 72394 An antibiotic. SGTC_3259 9138485 49.47 µM -2.19443525819922 0.0646117813644449 no 3151 0.0141020667517869 1069 17646153 SGTC_372 0155-0182 15.9 µM -2.19505920055951 0.064555476962913 no 3152 0.01407967569069 946 771486 SGTC_29 0299-0004 12.984 µM -2.195776622679 0.0644907840867693 no 3153 0.0140539678496843 1073 16871 A napthoquinone isolated from Swertia calycina. SGTC_2094 5332512 191.667 µM -2.19818966678483 0.0642735596226269 no 3154 0.0139677963692081 1079 755774 SGTC_603 3794-0023 45.9 µM -2.19943678950258 0.0641615155949297 no 3155 0.0139234395586695 1081 3802260 SGTC_2981 9013952 38.96 µM -2.20038911447427 0.0640760590760524 no 3156 0.0138896497429477 1062 2996344 SGTC_2136 5328288 199.296 µM -2.2006629892816 0.0640514994151262 no 3157 0.0138799453843872 1074 262395 SGTC_920 mycophenolic acid 780.421 nM -2.20493708180549 0.0636691688011219 no 3158 0.0137292549717927 1078 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2213 7173844 200 µM -2.20912286467304 0.0632964610001729 no 3159 0.0135830480820161 1078 892728 SGTC_2923 7992654 58.14 µM -2.21091220211955 0.0631376551439342 no 3160 0.0135209587662859 1058 2985126 SGTC_1940 st075990 51.1 µM -2.2109767838268 0.0631319292463328 no 3161 0.0135187223943234 1076 1084979 SGTC_2855 9016525 58.44 µM -2.22231774312342 0.0621326812492511 no 3162 0.013130919943817 1066 43811474 SGTC_1406 3909-7906 11.9 µM -2.22434210972916 0.0619556199221904 no 3163 0.0130627177792709 1036 X1406 SGTC_2114 5491910 81.25 µM -2.22503055912656 0.0618954944694166 no 3164 0.013039593370415 1075 2849228 SGTC_1822 st052468 42 µM -2.22866311178531 0.0615790007022645 no 3165 0.0129181642014853 1071 2873678 SGTC_699 0375-0592 111 µM -2.23106394075344 0.0613705180557793 no 3166 0.0128384469427978 1079 762578 SGTC_568 1193-0097 7.48 µM -2.23135845310462 0.061344981273117 no 3167 0.012828697299298 1021 3646150 SGTC_2038 4100038 30.985 µM -2.23726017008949 0.0608349990785153 no 3168 0.0126346703986841 1043 3596803 SGTC_1143 3454-2408 5.08 µM -2.25033398556197 0.0597170674107609 no 3169 0.0122138760517869 1046 X1143 SGTC_629 3448-6466 76.7 µM -2.25152973444635 0.0596156285766095 no 3170 0.0121760028971776 1080 573744 SGTC_2302 7771753 200 µM -2.25383708575874 0.0594202710123805 no 3171 0.0121032094001109 1059 2203047 SGTC_135 0933-0004 26.348 µM -2.2734182581483 0.0577825215531107 no 3172 0.0115004934515612 1056 21230617 YGL099W LSG1 SGTC_1828 st055811 49 µM -2.29575523218284 0.0559578439246908 no 3173 0.0108449402287218 1078 5877589 SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.30362425661971 0.0553259692459801 no 3174 0.0106218724991798 1080 165506 SGTC_1123 mangostin 811.285 nM -2.30560468074711 0.0551678340199437 no 3175 0.0105663657537184 1061 5281650 An antioxidant. SGTC_1690 st023502 41.2 µM -2.31397822558896 0.0545031562279957 no 3176 0.0103344582863242 1077 24207482 SGTC_2198 6589944 200 µM -2.31617580564407 0.0543297694432227 no 3177 0.0102743358187069 1073 5290268 SGTC_473 2-arachidonoylglycerol 10 µM -2.31624096119351 0.0543246354065893 no 3178 0.0102725579268557 1047 5282280 An endocannabinoid. SGTC_3142 9086498 49.47 µM -2.33027796182937 0.0532274869498955 no 3179 0.00989573238317083 1039 25236367 SGTC_723 4182-0001 115 µM -2.33754373188683 0.0526665251511482 no 3180 0.00970546489887004 1071 744821 YLR208W SEC13 SGTC_1520 flindersine 88 µM -2.33871496888697 0.0525765391767092 no 3181 0.00967509496726795 1061 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2193 5925765 200 µM -2.33942136625773 0.0525223257850187 no 3182 0.00965681840404713 1076 877370 SGTC_2170 morpholine 200 µM -2.34310838312551 0.0522400806786815 no 3183 0.00956191340590938 1084 121171 Reacts with secondary amines. SGTC_649 1123-0311 367 µM -2.34564156776416 0.0520468617144675 no 3184 0.00949718188963975 1068 693629 YIL048W NEO1 SGTC_266 formosanin C 406 nM -2.352024763258 0.0515625000529496 no 3185 0.00933576593092715 1065 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2393 9031399 185.94 µM -2.3530573742647 0.051484482639411 no 3186 0.00930988043627587 1078 1526623 YDL150W RPC53 SGTC_2982 9019404 25.97 µM -2.35449368212334 0.0513761206343624 no 3187 0.00927397950085764 1059 22333232 SGTC_618 k072-0232 33.2 µM -2.35568897699965 0.0512860801860069 no 3188 0.00924419517299556 1052 5872756 YGL099W LSG1 SGTC_1033 k072-0102 21.3 µM -2.35774068885 0.0511318193709965 no 3189 0.00919326580984915 1070 5965931 SGTC_2203 7227154 166.4 µM -2.36332984105422 0.050713463640371 no 3190 0.00905577089395934 1080 896304 SGTC_658 3253-0951 102 µM -2.36473037398288 0.0506090600941377 no 3191 0.00902160080144182 1080 1184878 SGTC_2881 9058953 51.95 µM -2.36959173216531 0.0502479952144246 no 3192 0.00890386850022423 1069 17122249 SGTC_2942 9052777 62.25 µM -2.37156031474842 0.050102369129285 no 3193 0.00885657769267487 1080 6469503 SGTC_340 k038-0059 454 µM -2.37252565978654 0.0500310806995629 no 3194 0.00883346797356785 1085 23733424 SGTC_1571 st070080 73.4 µM -2.37933953886122 0.0495301895817978 no 3195 0.00867184610762255 1079 4315245 SGTC_810 3825-7150 143 µM -2.3892821226991 0.0488064958436162 no 3196 0.00844066673730036 1051 22330411 YGL099W LSG1 SGTC_3087 9117406 49.47 µM -2.39224541907528 0.0485924478517716 no 3197 0.00837282042348375 1081 42546093 SGTC_3106 9121286 49.47 µM -2.39641855755536 0.0482922826876144 no 3198 0.00827808616140386 1068 15943471 SGTC_1975 st070967 30.8 µM -2.39651452449303 0.0482853974719237 no 3199 0.00827591873763199 1079 261391 SGTC_2540 epiandrosterone 100 µM -2.40175508869174 0.0479106002820636 no 3200 0.00815831422094998 1071 441302 A steroid. SGTC_2969 9091408 28.7 µM -2.40203794112014 0.0478904375334476 no 3201 0.00815200865103834 1074 4286311 SGTC_554 4483-2211 187 µM -2.40767576986287 0.0474899678651831 no 3202 0.00802721596488159 1087 747107 SGTC_1383 3049-0032 20.7 µM -2.42760611363687 0.0460957268115675 no 3203 0.00759941996225866 1077 712864 SGTC_2414 st077232 92.9 µM -2.42780046004636 0.0460822948196844 no 3204 0.00759534919282077 1071 729801 SGTC_737 1950-0117 57.9 µM -2.43954314820236 0.0452765312843404 no 3205 0.00735292317903132 1078 5393513 SGTC_713 1488-1073 324 µM -2.44911819465911 0.0446279302576299 no 3206 0.00716032232746789 1085 3312542 SGTC_130 0136-0219 337.655 µM -2.4547972786164 0.0442467858672511 no 3207 0.00704820285125162 1079 234244 SGTC_2481 5478948 45.16 µM -2.47678570479651 0.0427957404724175 no 3208 0.00662857364698168 1076 77792 SGTC_20 0481-0013 4.944 µM -2.48204341179459 0.0424545375297387 no 3209 0.00653156798007232 1082 182045 SGTC_2731 amoxapine 43.43 µM -2.48481599546661 0.0422754965764212 no 3210 0.00648092065215243 1092 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_607 4491-0986 66.8 µM -2.48873499577603 0.0420234677278847 no 3211 0.00640992415935411 1041 698981 YDR232W HEM1 SGTC_2261 9010538 184.68 µM -2.49613400598593 0.0415509575472205 no 3212 0.00627775798858242 1077 6457250 SGTC_2796 7949634 45.45 µM -2.50102614750959 0.0412409098118533 no 3213 0.00619170175847095 1073 2971588 SGTC_3167 9103034 49.47 µM -2.5125524718332 0.040517821568257 no 3214 0.00599306393869932 1092 5127859 SGTC_1937 st074714 47.2 µM -2.5151400160552 0.0403569183418618 no 3215 0.00594925595794717 1079 17250970 SGTC_1354 1498-1681 81 µM -2.516159715527 0.0402936522984483 no 3216 0.00593207025521939 1083 5754243 SGTC_51 1013-0126 23.419 µM -2.51635592443957 0.0402814879951037 no 3217 0.0059287684652412 1077 1627850 SGTC_988 1497-1057 103 µM -2.52044297073201 0.0400287820725005 no 3218 0.00586036146880361 1088 3533044 SGTC_1999 st074831 12.5 µM -2.52567265276357 0.039707306328507 no 3219 0.00577385121232121 1076 17112523 SGTC_1766 st045414 44.774 µM -2.52776859142613 0.0395790567661868 no 3220 0.0057394991971683 1080 253960 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.52848458949405 0.0395353224375575 no 3221 0.00572780576861637 1085 16623 A steroid. SGTC_1780 st038448 24.544 µM -2.53468946098872 0.0391579628456191 no 3222 0.00562735239276635 1076 728868 YDL195W SEC31 SGTC_1476 4112-3294 3.34 µM -2.53841469360176 0.038932818579797 no 3223 0.00556779735057274 1055 704369 SGTC_1994 st072947 40.9 µM -2.5402490813258 0.0388223404847564 no 3224 0.00553867735553948 1083 5286565 YDL195W SEC31 SGTC_1834 st055981 52.8 µM -2.54133351142177 0.0387571496279624 no 3225 0.00552152627118877 1085 471719 YDL150W RPC53 SGTC_444 curcumin 90.4 µM -2.56262862854518 0.0374949573315813 no 3226 0.00519415496657403 1068 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.57473400833843 0.0367925490802201 no 3227 0.00501586004651606 1084 7104 SGTC_65 0798-0905 34.986 µM -2.57533720602895 0.036757832227223 no 3228 0.0050071201150258 1084 3602145 SGTC_1249 0481-0015 10.2 µM -2.57583600208892 0.0367291444178141 no 3229 0.0049999031416683 1074 4227577 SGTC_1219 1469-0211 33.1 µM -2.57586453247854 0.0367275040717802 no 3230 0.00499949062184218 1073 6822282 SGTC_2345 9052315 157.45 µM -2.57654519728193 0.0366883872201607 no 3231 0.00498965789992021 1076 6469265 SGTC_2406 ethylparaben 405.7 µM -2.57663045460152 0.0366834900039421 no 3232 0.00498842750766049 1080 8434 A possible steroid mimic. SGTC_1699 st031318 29.054 µM -2.6146792308336 0.0345507242974958 no 3233 0.00446556440622308 1084 5340658 SGTC_732 3970-1727 52.7 µM -2.61650730989722 0.0344508740845872 no 3234 0.00444172311018605 1089 1275699 SGTC_2455 5377712 9.75 µM -2.61653497035168 0.0344493650852579 no 3235 0.00444136324514905 1085 2243908 SGTC_1318 1280-3875 124 µM -2.61771195718597 0.034385205584483 no 3236 0.00442607465033409 1082 373245 SGTC_1849 st056239 19.2 µM -2.61775072016182 0.03438309422181 no 3237 0.00442557193522514 1081 5393181 SGTC_1970 st070122 35.8 µM -2.62423776102446 0.0340312524120879 no 3238 0.0043421569388133 1083 102928 SGTC_1201 1889-3372 45.9 µM -2.62650059126536 0.0339092205091221 no 3239 0.0043133921307937 1081 5392199 SGTC_423 5-fluorouracil 457 µM -2.63471301936175 0.0334693535057358 no 3240 0.00421042231153291 1072 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2636 apigenin dimethyl ether 100 µM -2.63935811396057 0.0332226439459053 no 3241 0.00415315926254011 1082 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_23 0213-0011 39.996 µM -2.65076633519692 0.0326230842891034 no 3242 0.00401546903512926 1083 627608 SGTC_1561 5-methoxyflavone 52.9 µM -2.66856733620119 0.0317053980430709 no 3243 0.00380877537585452 1078 94525 SGTC_211 3455-0679 143.504 µM -2.68213771407129 0.0310202291217408 no 3244 0.00365766693282323 1076 748649 SGTC_2089 5281248 129.67 µM -2.6840614433956 0.0309240988827999 no 3245 0.00363668688913246 1083 2737878 SGTC_361 000s-0510 1.45 µM -2.68540206353499 0.0308572529446737 no 3246 0.00362213010404258 1081 660 SGTC_2695 st077686 51.995 µM -2.68621886499866 0.0308165842959613 no 3247 0.00361328672743102 1080 2876092 SGTC_2382 9035899 200 µM -2.69436374944124 0.0304134715860847 no 3248 0.00352615767481521 1085 6462679 SGTC_1759 st043059 70 µM -2.69850988830016 0.03020995176323 no 3249 0.00348253343373337 1085 669426 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.7030811849138 0.0299868721470931 no 3250 0.00343499821665624 1079 688664 SGTC_522 1273-0010 11.6 µM -2.70581212761162 0.0298542549686574 no 3251 0.00340687909840703 1080 5705015 SGTC_405 ebelactone b 50 µM -2.70748022959009 0.0297734899500013 no 3252 0.00338980543454314 1079 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1795 st049545 62.3 µM -2.7132639211208 0.0294948617857822 no 3253 0.00333120105972166 1084 5291882 SGTC_560 2332-1943 155 µM -2.72756279414257 0.0288152964587749 no 3254 0.00319020561562507 1091 21177716 SGTC_1347 1493-0251 600 nM -2.72870683654942 0.0287614919516411 no 3255 0.0031791600916809 1030 3986378 SGTC_2841 9004761 38.96 µM -2.74355799425223 0.0280705881940409 no 3256 0.00303886557852346 1079 2991039 SGTC_2064 5220758 200 µM -2.74481451275391 0.0280127721199241 no 3257 0.00302725539177055 1087 788518 SGTC_117 lucigenin 22.078 µM -2.75190241950271 0.0276884914645643 no 3258 0.00296250864918754 1084 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1604 st002052 72.4 µM -2.75359640705873 0.0276114543247067 no 3259 0.00294722034480911 1087 6254834 YHR062C RPP1 SGTC_2062 5245942 200 µM -2.76033011453052 0.0273069912632436 no 3260 0.0028871490631206 1091 1376160 SGTC_1304 1165-0502 251 µM -2.76046278927464 0.0273010206481887 no 3261 0.00288597664570324 1087 767425 SGTC_2913 7966556 36.57 µM -2.77022489118758 0.0268646856420991 no 3262 0.00280088000164106 1066 2976516 SGTC_1827 berberine 7.24 µM -2.77770688372 0.0265342190066583 no 3263 0.00273719888178641 1055 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_59 0330-0160 1.33 µM -2.79161458958734 0.0259289628346798 no 3264 0.00262228918937588 1090 4293482 SGTC_1047 2043-3044 82 µM -2.80849026504332 0.0252100956305149 no 3265 0.00248871936414731 1087 669592 SGTC_2802 7925815 54.55 µM -2.80932966038766 0.0251747796171326 no 3266 0.00248223913492065 1082 1262923 SGTC_1020 4335-0961 93.3 µM -2.81462247621776 0.0249530478332748 no 3267 0.0024417282581179 1082 669075 SGTC_3222 9128301 49.47 µM -2.82987856399882 0.024323068783187 no 3268 0.00232828373736586 1062 4911358 SGTC_2755 lomerizine 42.69 µM -2.83531612462294 0.0241017847117714 no 3269 0.00228901800899917 1082 3949 A calcium channel blocker. SGTC_857 0438-0306 1.35 µM -2.83741656052848 0.0240167605149574 no 3270 0.00227401162180467 1086 4686136 SGTC_2444 5485484 36.41 µM -2.84376097254708 0.0237614720066632 no 3271 0.00222922404670133 1088 6790631 SGTC_751 0833-0568 350 µM -2.85732022794755 0.0232235123049364 no 3272 0.00213617285005213 1089 6954252 SGTC_2389 9091542 195.52 µM -2.860227158426 0.0231095251549356 no 3273 0.00211668826850666 1087 3626624 YOL127W RPL25 SGTC_1010 4112-3296 15.2 µM -2.86581859381612 0.0228915969723454 no 3274 0.00207966257248183 1081 704384 SGTC_1296 1068-0102 11.9 µM -2.88219169014779 0.0222633839920216 no 3275 0.00197459700809003 1092 767053 SGTC_2472 5377652 49.4 µM -2.88446864858972 0.0221771831612727 no 3276 0.00196037397884796 1092 1610903 SGTC_379 3970-0972 5.9 µM -2.89178750188702 0.0219020121795801 no 3277 0.0019152846817461 1093 2898042 YBL034C STU1 SGTC_2883 9059145 45.46 µM -2.89766998926366 0.0216829400815005 no 3278 0.00187972971613817 1090 16476510 SGTC_1169 aniline yellow 25.8 µM -2.91107066597863 0.02119078439448 no 3279 0.00180096271940128 1086 6051 A DNA damaging agent. SGTC_2422 chlorphenesin carbamate 384.24 µM -2.94221005520872 0.0200835344907459 no 3280 0.0016293939767372 1078 2724 A muscle relaxant with antifungal properties. SGTC_848 0368-0089 85.6 µM -2.9589853568752 0.0195076520008408 no 3281 0.00154326883683423 1088 762535 SGTC_3085 9117376 49.47 µM -2.96500920865452 0.0193043094087094 no 3282 0.00151336934656579 1084 16480349 SGTC_1306 1185-0270 9.02 µM -2.97409559482216 0.0190009962433624 no 3283 0.00146926756519457 1089 1548076 SGTC_1926 methyl fluorone black 53.6 µM -2.99604851943612 0.0182848675423171 no 3284 0.00136751455953426 1073 72721 Reacts with homocysteine. SGTC_1206 3978-0017 132 µM -2.99739386026154 0.0182417390131614 no 3285 0.00136149330407566 1078 3873677 SGTC_1045 1348-1485 165 µM -3.00382845435911 0.0180366575809526 no 3286 0.0013330280082079 1089 6810614 SGTC_581 0958-0271 211 µM -3.01235319433946 0.0177679893731989 no 3287 0.00129615394408629 1088 4591145 SGTC_1972 st070201 17.4 µM -3.02646327954813 0.0173307947005763 no 3288 0.00123716436325643 1092 2829099 SGTC_1830 st055982 50.3 µM -3.03073042968807 0.0172004019954524 no 3289 0.00121981475925391 1094 455313 An antimicrobial agent. SGTC_2404 5161160 200 µM -3.03210187694505 0.0171586726231114 no 3290 0.00121428611836664 1083 2831543 SGTC_958 1222-0007 33 µM -3.03629995195635 0.0170314740337829 no 3291 0.00119750488388646 1090 7312461 SGTC_1829 berberine 14.4 µM -3.04708906597266 0.0167082638440156 no 3292 0.00115534615769613 1056 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -3.05808662273298 0.0163842243555054 no 3293 0.00111377587614129 1095 368090 SGTC_990 3985-0011 41.3 µM -3.06408817146345 0.0162096711068558 no 3294 0.00109167275472917 1077 5399565 YGL099W LSG1 SGTC_1934 st074720 32.6 µM -3.0938142879195 0.0153683980841911 no 3295 0.000988005676492974 1082 17250992 SGTC_2727 riluzole 51.77 µM -3.09691586560715 0.0152828203388696 no 3296 0.000977726824091807 1094 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2729 fluphenazine 10.66 µM -3.10217424801285 0.0151386677891309 no 3297 0.000960524227543032 1089 3372 An atypical antipsychotic. SGTC_2924 9010168 62.78 µM -3.12997520811364 0.0143958008497023 no 3298 0.000874105283406482 1089 2993929 SGTC_1507 4075-3230 155 µM -3.14345144896546 0.0140471430581072 no 3299 0.000834840556783689 1075 659771 SGTC_3191 9110352 49.47 µM -3.21251686664762 0.0123722836953213 no 3300 0.000657887111672058 1087 17122424 SGTC_2232 chlorophetanol 41.5365 µM -3.22327883465662 0.0121275295450577 no 3301 0.000633660612529721 1090 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3243 9134147 49.47 µM -3.23221588611971 0.0119274794246109 no 3302 0.000614171084467756 1080 24282180 SGTC_383 2324-0395 7.37 µM -3.23343963078399 0.0119003107271049 no 3303 0.000611545915579611 1072 3146421 SGTC_53 0973-0023 39.979 µM -3.255635226496 0.0114167753958412 no 3304 0.000565695025664568 1089 674768 SGTC_1775 st081588 35.1725 µM -3.25613903497417 0.0114060009081577 no 3305 0.000564692164322201 1076 1426443 YGL099W LSG1 SGTC_2446 5162541 200 µM -3.27050047614482 0.011102559206442 no 3306 0.000536786807468023 1092 1549321 SGTC_183 3914-0051 30.55 µM -3.27079194150999 0.0110964742512693 no 3307 0.000536233908851411 1091 1596232 SGTC_2867 9039098 71.43 µM -3.28551356661648 0.0107928784446179 no 3308 0.000508983200271681 1087 6463460 SGTC_259 usnic acid 108.925 µM -3.28741062991603 0.0107542871885076 no 3309 0.000505566385675587 1094 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_104 0074-0074 590.992 µM -3.29529112880549 0.0105952604016638 no 3310 0.00049159881731595 1092 3943124 SGTC_1605 st000082 49.1 µM -3.34669434422993 0.00960734395276941 no 3311 0.000408906653368895 1088 1114022 SGTC_263 alizarin 107.927 µM -3.35657161147904 0.00942702173142619 no 3312 0.000394576407282555 1084 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2362 9071156 126 µM -3.37260039029176 0.00914069228665701 no 3313 0.000372309679723075 1092 653133 SGTC_2687 chenodiol 100 µM -3.38801497332764 0.00887254568438671 no 3314 0.000352002104737147 1085 5702181 A cholesterol synthesis inhibitor. SGTC_339 3091-4833 71.4 µM -3.4132346415564 0.00844868516640588 no 3315 0.000320983216336271 1086 3240077 SGTC_1848 st056003 16.4 µM -3.42668708016369 0.00822994491866574 no 3316 0.000305496360556333 1091 146492 SGTC_2739 tacrine 100.86 µM -3.44896583643181 0.00787861693312902 no 3317 0.000281368947095845 1035 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2488 5268135 45.7 µM -3.4546230218815 0.00779153296595041 no 3318 0.000275531372461856 1088 1270356 YLR208W SEC13 SGTC_1959 st077091 55.8 µM -3.47536652879699 0.00747942147905838 no 3319 0.000255077894416824 1089 821356 YKL052C ASK1 SGTC_431 k089-0097 107 µM -3.4930546663535 0.00722203676029131 no 3320 0.000238764370764801 1059 5499420 SGTC_562 3772-2733 112 µM -3.50659492532177 0.00703031942697485 no 3321 0.000226939757052956 1095 2876874 YIL048W NEO1 SGTC_2968 9090663 33.37 µM -3.5648065742282 0.00625632013253839 no 3322 0.000182062309246384 1082 25236811 SGTC_2749 bexarotene 57.39 µM -3.57134044324949 0.00617433756999313 no 3323 0.00017757944313663 1091 82146 An retinoic acid receptor inhibitor. SGTC_1854 st056233 32.9 µM -3.61733890122039 0.00562362514833032 no 3324 0.000148823736028495 1095 5393174 SGTC_2244 6635614 200 µM -3.62880566664454 0.00549332210455274 no 3325 0.000142367737631815 1095 836499 SGTC_2854 9024559 71.43 µM -3.63981479738739 0.00537075083395172 no 3326 0.000136417102484382 1085 3163529 SGTC_2666 tannic acid 100 µM -3.64442529559532 0.00532014594254113 no 3327 0.000133994979759796 1092 16134267 A thiamine antagonist. SGTC_1764 st044502 93.5 µM -3.66148653542263 0.00513654966872723 no 3328 0.00012537802101251 1092 8407 SGTC_335 4077-0256 27.6 µM -3.69948936165502 0.00474773015730082 no 3329 0.000108016847601278 1089 3121989 SGTC_3004 9076122 71.4286 µM -3.70299159473807 0.00471325375544003 no 3330 0.000106535972073093 1092 44782551 SGTC_1681 tripelennamine 100 µM -3.70582672820708 0.00468550810849207 no 3331 0.000105351157357661 1086 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2418 pentamidine 31.67 µM -3.71423847957043 0.00460404317171742 no 3332 0.000101908260879178 1079 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2964 9083345 53.42 µM -3.73491427082281 0.00440915279866048 no 3333 9.38895719079531e-05 1090 17741579 SGTC_816 0325-0417 81.3 µM -3.75298010148953 0.00424493339496327 no 3334 8.73723653967021e-05 1089 68101 SGTC_2448 5185112 27.17 µM -3.78268412923478 0.00398678475812791 no 3335 7.75731231860359e-05 1094 5718189 SGTC_1450 4112-4260 37.6 µM -3.81219544478965 0.00374432379448617 no 3336 6.88689465428514e-05 1093 1633175 SGTC_930 2810-3379 265 µM -3.8276074368679 0.00362303113574724 no 3337 6.46974549756787e-05 1092 1015764 SGTC_2424 5537928 59.2 µM -3.86460886048392 0.00334610219328626 no 3338 5.56336788962378e-05 1089 5382802 SGTC_173 1273-0061 2.693 µM -3.89852165162445 0.00310916126865267 no 3339 4.83908741534016e-05 1083 2847414 YPL266W DIM1 SGTC_3108 9121785 49.47 µM -3.90613601601631 0.00305808390150925 no 3340 4.68918677831429e-05 1079 17140271 SGTC_2460 5552655 174.22 µM -3.93505488138795 0.00287090969818077 no 3341 4.15888435211909e-05 1094 5401989 SGTC_2686 alizarin 95.37 µM -3.95455568030776 0.00275059194526144 no 3342 3.8338506983107e-05 1088 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_430 0958-0115 16.4 µM -3.95828108164967 0.00272813124630859 no 3343 3.77455440530435e-05 1092 6833180 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -4.04778683532274 0.0022359197584885 no 3344 2.58521005225241e-05 1093 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2675 theaflavin digallate 100 µM -4.118674574449 0.00190481938590436 no 3345 1.90528915945931e-05 1094 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2243 6634756 200 µM -4.23792666931768 0.00144687327047924 no 3346 1.12796711045087e-05 1094 885676 SGTC_1135 dihydrocapsaicin 536.708 nM -4.24282313930892 0.00143042249459096 no 3347 1.10362692355558e-05 1094 107982 A Capsaicinoid. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -4.33058203679437 0.00116309902755051 no 3348 7.43578635099904e-06 1094 676296 Flavone; oxidizing agent. SGTC_1958 st076513 41.9 µM -4.41270826939116 0.000955197283521117 yes 3349 5.10427561643823e-06 1095 732122 YGL099W LSG1 SGTC_49 0717-0965 32.132 µM -4.74426970524844 0.000417425468328861 yes 3350 1.04629945582303e-06 1094 5889349 YGL099W LSG1 SGTC_3075 9116269 49.47 µM -4.94274038743583 0.000247976587435311 yes 3351 3.85160164853448e-07 1095 17015205 YNL244C SUI1 SGTC_1522 st012842 45.6 µM -5.00080438986234 0.000212170500092764 yes 3352 2.85458071609869e-07 1089 3491067 YOR116C RPO31 SGTC_2451 5856223 45.7 µM -5.02463221407633 0.000198924273345679 yes 3353 2.5219910790523e-07 1091 2179896 SGTC_1124 fisetin 1.16336 µM -5.74197190863526 2.51107695548707e-05 yes 3354 4.67901745064635e-09 1093 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_374 0880-0231 82.3 µM -6.94663224247247 4.41104571995023e-07 yes 3355 1.87054622543652e-12 1095 6833587 SGTC_3072 9116419 49.47 µM -7.05115448424083 3.00331501333132e-07 yes 3356 8.87196801164761e-13 1095 17170162