SGTCid condition conc unit TFB4|YPR056W.score TFB4|YPR056W.strain.pval TFB4|YPR056W.strain.significant TFB4|YPR056W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_821 1114-0266 29.2 µM 4.81596955621518 2.84897510313013e-07 yes 1 7.3243428973975e-07 2 3123235 SGTC_1323 1348-1351 11.2 µM 4.37756301182402 2.69642245388248e-06 yes 2 6.00068350732837e-06 2 6989654 SGTC_219 mitoxanthrone 164.414 µM 4.32792519137588 3.43486933446308e-06 yes 3 7.52602865340773e-06 11 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2471 5466956 24.79 µM 4.24551255136207 5.10534984496539e-06 yes 4 1.09047149736699e-05 13 724419 SGTC_3057 9095946 49.47 µM 4.07071052517518 1.15643636400536e-05 yes 5 2.34349810111118e-05 4 24540043 SGTC_3225 9130819 49.47 µM 3.60499817178443 8.77615031005927e-05 yes 6 0.000156077562920412 13 4547121 SGTC_815 1582-0027 36.9 µM 3.58571493400349 9.499310672753e-05 yes 7 0.000168078003429016 6 3128206 SGTC_944 3370-0224 231 µM 3.52254413388143 0.000122801681617831 yes 8 0.00021371293445885 9 4580514 SGTC_960 1222-0186 7.7 µM 3.4312941536417 0.000176685362417908 yes 9 0.00030035441886279 15 3126296 SGTC_3197 9113331 49.47 µM 3.39736990334535 0.000201842048010396 yes 10 0.00034018465111502 17 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1293 1000-1278 195 µM 3.30607703526498 0.00028713966137561 yes 11 0.000473060360399223 15 678847 SGTC_885 0865-0106 16.8 µM 3.29310325448836 0.000301684665457735 yes 12 0.000495440389028459 25 2793380 SGTC_1783 st039459 87.517 µM 3.21495171042619 0.000404832987257016 yes 13 0.000652332338388777 16 729761 SGTC_1464 k208-0027 110 µM 3.19054021481944 0.000443228452970827 yes 14 0.000710035380579785 9 X1464 SGTC_370 0180-0345 38.7 µM 3.18961194198891 0.000444753033560823 yes 15 0.000712319760896208 14 3989527 SGTC_2507 purpurin 79.67 µM 3.14398876459325 0.00052596010781361 yes 16 0.000833309192231871 12 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_515 4092-1064 102 µM 3.11976078916665 0.000574465770355679 yes 17 0.000904989806511597 29 717353 SGTC_845 0330-0138 4.51 µM 3.00814176642265 0.000856023542055113 yes 18 0.00131425245236942 18 9039800 SGTC_2964 9083345 53.42 µM 2.99145108016539 0.000907664720221031 yes 19 0.00138827510420624 30 17741579 SGTC_2648 atorvastatin 78.68 µM 2.97141012709117 0.000973448322713074 yes 20 0.00148217810773634 17 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2941 9056145 11.23 µM 2.93965508395568 0.00108669490439828 no 21 0.00164288895464242 18 2119517 SGTC_1385 3091-4834 14.1 µM 2.88574158047564 0.00130695057107335 no 22 0.00195246321542554 16 4072814 SGTC_3141 9094609 49.47 µM 2.86519472129118 0.00140112429325398 no 23 0.00208376444442919 35 25236309 YDL196W YDL196W SGTC_2093 5331342 194.4 µM 2.86417427522223 0.00140595903927193 no 24 0.00209048955438307 19 33839 SGTC_2495 cafestol 54.53 µM 2.85166024393074 0.00146650064726638 no 25 0.00217457794385461 28 16667697 An anti-infammatory. SGTC_931 2812-0076 566 µM 2.847315425113 0.00148807064382039 no 26 0.00220448265241774 22 3450959 SGTC_2567 aureobasidin a 60 nM 2.83502441711673 0.00155066676357977 no 27 0.00229110916676706 76 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1711 st032263 62.8 µM 2.81596078462317 0.00165251617445394 no 28 0.00243158012039636 12 3958979 SGTC_2173 5763948 167 µM 2.798758610778 0.00174961134863791 no 29 0.00256497358130178 12 2867177 SGTC_2085 5307070 144.047 µM 2.7835045937215 0.00184002299556239 no 30 0.00268875504855525 28 2840351 SGTC_757 1066-0008 322 µM 2.76412663166798 0.00196099724116308 no 31 0.00285376922600386 15 6842497 SGTC_3198 9112019 49.47 µM 2.75604531097419 0.00201354862460859 no 32 0.00292524458645968 22 45595555 SGTC_1272 0839-0021 27 µM 2.73443347792171 0.00216042674094285 no 33 0.00312438601526571 24 5027250 SGTC_1427 4048-4900 550 nM 2.72515218843779 0.00222643417602086 no 34 0.00321359269634545 13 24132586 SGTC_1643 st009866 20.2 µM 2.7001356502719 0.00241354824897609 no 35 0.00346556045924243 36 3156273 YOR207C RET1 SGTC_1716 st033144 30.6155 µM 2.61204934374131 0.00319104766562572 no 36 0.00450006314931702 24 674617 SGTC_2558 carylophyllene oxide 100 µM 2.59672632765888 0.00334728536885114 no 37 0.00470584391058471 14 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3189 9110682 49.47 µM 2.58579690915349 0.0034628909149476 no 38 0.00485770783711978 25 17122418 SGTC_1299 1079-1439 3.74 µM 2.57226048686747 0.00361103692942589 no 39 0.00505184198017032 20 323161 SGTC_2597 laccaic acid a 100 µM 2.57016850504526 0.00363443275035726 no 40 0.00508245292544836 35 5491415 A textile dye. SGTC_2326 6164455 177.58 µM 2.56581367298428 0.0036835721003265 no 41 0.0051467052624792 44 2888790 SGTC_65 0798-0905 34.986 µM 2.53386562203455 0.00406267383733318 no 42 0.00564059918408243 36 3602145 SGTC_1079 idarubicin 2.36 µM 2.52138702160573 0.00421998810547003 no 43 0.00584466029438882 26 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1452 4194-0072 190 µM 2.51971314098864 0.0042414995134394 no 44 0.005872525412735 26 1343545 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.5190618666952 0.00424989564528812 no 45 0.00588339899018472 24 4213774 SGTC_947 3447-0010 211 µM 2.50451966275905 0.00444128343970909 no 46 0.0061308894762152 26 748350 SGTC_2977 9011197 71.43 µM 2.49902021345612 0.00451564368987113 no 47 0.0062268603667272 26 2704722 SGTC_3058 9093861 49.47 µM 2.49866186309952 0.00452052744674603 no 48 0.00623315986118324 25 17217477 SGTC_1905 st060207 84.5 µM 2.4751063461301 0.00485208074099884 no 49 0.00665982538410196 22 1948547 SGTC_1253 0550-0034 176 µM 2.44924798382473 0.00524085265148827 no 50 0.00715774249645217 38 5969915 SGTC_904 1141-0088 396 µM 2.43932361624926 0.00539727013195375 no 51 0.00735739207619085 24 1378119 SGTC_3154 9100113 49.47 µM 2.43008278339961 0.00554663141957706 no 52 0.00754768725895808 36 25237525 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.42567559433865 0.00561915022962533 no 53 0.00763996095468717 30 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1209 2323-2347 50.3 µM 2.39708165069857 0.00611044479624733 no 54 0.00826312030314526 31 5412760 SGTC_1092 toremifene 6.32 µM 2.39558271860749 0.00613721829399156 no 55 0.00829698476478949 29 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2013 4024628 200 µM 2.38961288785247 0.00624488378256157 no 56 0.00843306983619267 37 5230760 SGTC_1318 1280-3875 124 µM 2.38380178528182 0.00635128966899839 no 57 0.00856741438001581 29 373245 SGTC_1746 st038117 42 µM 2.37694495375793 0.00647890510462857 no 58 0.00872834649913537 28 2898218 SGTC_3228 9131799 49.47 µM 2.37606195479677 0.00649550275406877 no 59 0.00874926222495923 23 17015818 SGTC_1809 st050081 57.6 µM 2.37480878009048 0.00651912312864975 no 60 0.00877902178879255 26 5036894 SGTC_2356 9061756 188.97 µM 2.37120138583514 0.00658754148425817 no 61 0.0088651837154324 25 20104043 SGTC_1659 st012954 42.1 µM 2.3664602561802 0.00667842761680578 no 62 0.00897955119472458 21 24207262 SGTC_224 benfluorex 43.875 µM 2.34535099823561 0.0070966751259372 no 63 0.00950458742664573 25 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3243 9134147 49.47 µM 2.33964886886825 0.00721354715870467 no 64 0.00965093867367118 21 24282180 SGTC_2885 9057732 51.95 µM 2.32840572281548 0.00744897181756143 no 65 0.00994528503270374 25 6471414 SGTC_1077 5-fluorocytosine 377 nM 2.32223976254534 0.00758093642834638 no 66 0.0101100145244298 50 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2950 9072895 21.46 µM 2.31772201168327 0.00767892845106785 no 67 0.0102322169734234 32 17332245 SGTC_2182 6325192 200 µM 2.29964662432029 0.00808223452801594 no 68 0.0107341241767051 23 736248 SGTC_983 1491-0821 12.2 µM 2.29431012751346 0.0082048111281714 no 69 0.0108863456313588 39 46495113 SGTC_3312 9133330 71.43 µM 2.29348250885921 0.00822396666659465 no 70 0.0109101206148707 26 17617324 SGTC_222 nsc-310342 10.666 µM 2.27036056564587 0.00877525165908966 no 71 0.0115928575321002 16 432556 SGTC_3045 9092950 49.47 µM 2.2597298351939 0.00903940677382375 no 72 0.0119190117143551 21 44120432 SGTC_1703 st026983 48.3 µM 2.25753635106867 0.00909476964865809 no 73 0.0119872903589964 26 1104023 SGTC_770 0389-1121 67.2 µM 2.25578215066398 0.00913925857736227 no 74 0.0120421388637928 40 6753108 SGTC_3107 9121808 49.47 µM 2.24414920923365 0.00943913595207538 no 75 0.0124114013451737 25 662681 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.24087454567765 0.00952508842783407 no 76 0.0125171012421779 37 5024745 SGTC_225 nsc-122657 1.016 µM 2.2229321633517 0.010008285625873 no 77 0.0131101872929881 31 275685 SGTC_1405 3909-7894 12 µM 2.22124847579251 0.0100547076150148 no 78 0.0131670682653547 22 7104060 SGTC_890 0929-0006 47.2 µM 2.20369527341878 0.0105499789500728 no 79 0.0137728908969202 25 1378169 SGTC_1423 4048-0112 5.59 µM 2.19895553857752 0.0106873043285228 no 80 0.0139405419522242 38 X1423 SGTC_1301 naphtanilide LB 4.81 µM 2.1967102688078 0.0107528986027099 no 81 0.014020572506704 56 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3227 9130768 49.47 µM 2.18852836887689 0.0109949030438394 no 82 0.0143155685715069 25 17720899 SGTC_2640 pentamidine 10.38 µM 2.17843349833835 0.011300007917758 no 83 0.0146868891107814 59 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2605 digitonin 300 nM 2.1666245559291 0.0116662334783727 no 84 0.0151317467186481 53 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1322 1348-1070 12 µM 2.16537865465599 0.0117054664293678 no 85 0.0151793496665313 32 6758089 SGTC_1114 scopoletin 1.73284 µM 2.16526066296043 0.0117091878719142 no 86 0.0151838645126403 28 5280460 A coumarin with genotoxic properties. SGTC_2867 9039098 71.43 µM 2.14541863489015 0.0123497910017695 no 87 0.0159596952408654 48 6463460 SGTC_223 busulfan 5 mM 2.13763903008423 0.0126091204770883 no 88 0.0162730257144476 38 2478 A DNA alkylator. SGTC_2846 9008642 19.48 µM 2.1252100432742 0.0130332161558929 no 89 0.0167845451915709 57 2992898 SGTC_590 k048-0076 22.4 µM 2.12314490007424 0.0131048636150352 no 90 0.0168708557533047 55 6832814 SGTC_2106 5357045 167.29 µM 2.11690107478466 0.013323559216023 no 91 0.0171341222225527 38 668842 SGTC_1569 carminic acid 40.6 µM 2.11676793900705 0.0133282565351256 no 92 0.0171397738118452 35 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_352 k048-0007 5.11 µM 2.11505026367626 0.0133889882346745 no 93 0.0172128317891396 63 6811911 SGTC_1236 0330-0013 258 µM 2.11237675159244 0.0134839907886774 no 94 0.0173270737174163 25 4617066 SGTC_1159 4092-0538 61.2 µM 2.10547912495224 0.0137317879503997 no 95 0.0176248112820797 52 717301 SGTC_356 1634-0012 32.5 µM 2.10497297774776 0.0137501250107791 no 96 0.0176468301712739 48 735457 SGTC_3259 9138485 49.47 µM 2.10295636754714 0.0138233940831135 no 97 0.0177347918840603 36 17646153 SGTC_637 1181-0519 7.26 µM 2.10178894069678 0.0138659636504487 no 98 0.0177858841740629 53 6252091 YGR060W ERG25 SGTC_3339 9145883 14.936 µM 2.08743642521154 0.0143986278158286 no 99 0.018424351113665 22 2030670 SGTC_1198 1612-1005 86.7 µM 2.08259567718786 0.0145822120416863 no 100 0.0186440467915108 53 6998509 SGTC_2980 9014342 25.29 µM 2.06590751344356 0.0152306301053861 no 101 0.0194186066450621 79 2996599 SGTC_1450 4112-4260 37.6 µM 2.0657221068932 0.0152379709831162 no 102 0.0194273633268336 45 1633175 SGTC_2965 9082772 38.63 µM 2.0518497292177 0.0157959151987698 no 103 0.0200921343339341 28 16459634 SGTC_439 amiodarone 34.4 µM 2.03647884921368 0.0164345033333833 no 104 0.0208511474259906 45 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_133 0724-0033 378.92 µM 2.03526931295082 0.0164856790213613 no 105 0.0209118910627951 51 280309 SGTC_2457 5731572 11.68 µM 2.03292633846442 0.0165851988186581 no 106 0.0210299827994067 49 2865357 SGTC_3274 9138298 49.47 µM 2.02956189268715 0.0167290054590904 no 107 0.021200545869172 53 17015756 SGTC_724 3910-0327 137 µM 2.02621163817077 0.0168732641727418 no 108 0.0213715507591784 56 2885483 SGTC_2496 diffractaic acid 79.83 µM 2.021984744313 0.017056786752989 no 109 0.021588963965205 55 94870 An apoptosis inducer which activates caspases. SGTC_3161 9100388 49.47 µM 2.01336584053843 0.0174362920816857 no 110 0.0220380782389737 43 25236368 SGTC_2713 st079149 53.4 µM 2.00707871512485 0.0177176524962385 no 111 0.0223706411034793 47 3103253 SGTC_1978 st071761 42 µM 2.00426692497374 0.017844733579139 no 112 0.0225207374436823 55 5147680 SGTC_1040 k898-0338 155 µM 2.00323950947709 0.0178913619876846 no 113 0.0225757933871875 46 20969351 SGTC_1244 0416-0015 52.5 µM 1.99904109988922 0.018082984786676 no 114 0.0228019535598779 41 96201 SGTC_2190 6049624 200 µM 1.996377746527 0.0182054496750737 no 115 0.0229464105982842 38 2265554 SGTC_1384 3089-0840 101 µM 1.99298152462743 0.0183626375952431 no 116 0.0231317351016663 27 1069836 SGTC_749 1000-0129 128 µM 1.97248944010668 0.0193358106144597 no 117 0.0242768803080134 48 708470 SGTC_1430 4049-0248 69.1 µM 1.97225877718274 0.0193470095826495 no 118 0.0242900364550162 35 22774488 SGTC_367 0335-0881 7.1 µM 1.96965200857617 0.0194739549614168 no 119 0.0244391333437644 78 23828853 SGTC_403 arphamenine a 50 µM 1.91856763221793 0.0221081323321463 no 120 0.0275195376045953 64 5487158 An arginine aminopeptidase inhibitor. SGTC_411 enrofloxacin 100 µM 1.91268422321164 0.0224299842003325 no 121 0.0278942450610899 38 71188 A bacterial gyrase inhibitor. SGTC_829 1635-0120 117 µM 1.91058804957819 0.0225456061030563 no 122 0.0280287706557982 103 285054 SGTC_3193 9111931 49.47 µM 1.90935835793028 0.0226136676875672 no 123 0.0281079393969345 50 17087244 SGTC_783 0848-0141 92.7 µM 1.906454774487 0.0227750642904738 no 124 0.0282956139918063 68 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1861 st057647 17.4 µM 1.90168858816634 0.0230420983808931 no 125 0.0286059393279719 51 688668 SGTC_1795 st049545 62.3 µM 1.89458022084122 0.0234452529329739 no 126 0.0290740186175458 30 5291882 SGTC_2618 avocadyne 43.43 µM 1.88601660361877 0.0239388084808252 no 127 0.0296463586279596 44 3015189 SGTC_1015 4130-4525 82 µM 1.88544464608963 0.0239720814634106 no 128 0.0296849155732032 61 1363237 SGTC_169 k015-0017 16.025 µM 1.88209916985388 0.0241674801524926 no 129 0.029911276034357 47 1840002 SGTC_894 0960-0238 55.9 µM 1.8776032863425 0.0244321759630523 no 130 0.0302177279198989 71 6741907 YDL195W SEC31 SGTC_1335 1486-0900 202 µM 1.87307328380992 0.0247013377185903 no 131 0.030529132994279 52 X1335 SGTC_2838 9002687 71.43 µM 1.87174097936758 0.0247809718379023 no 132 0.0306212235877536 86 6457060 SGTC_1854 st056233 32.9 µM 1.87015749914436 0.0248758991227573 no 133 0.0307309748526024 55 5393174 SGTC_2234 tolnaftate 200 µM 1.86610636214918 0.0251201476882288 no 134 0.0310132430220492 27 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2348 9022543 33.42 µM 1.85125436643852 0.0260328525703797 no 135 0.0320664838636319 110 3162678 YDL140C RPO21 SGTC_668 1682-0499 62.6 µM 1.84900693229736 0.026173352066228 no 136 0.0322284058623076 58 682214 SGTC_1733 st037357 54.9 µM 1.84023453885664 0.0267278443208754 no 137 0.0328669056238521 66 1272339 YGL099W LSG1 SGTC_373 0844-0104 25.9 µM 1.83313097127794 0.0271840099386342 no 138 0.0333915481343386 81 5375804 SGTC_1825 st052143 62.6 µM 1.82901388070774 0.0274513553262544 no 139 0.0336987644265807 59 674173 SGTC_2906 7926292 26.41 µM 1.81229814831078 0.0285594196355383 no 140 0.0349700702628832 53 2966319 SGTC_2781 5567276 71.43 µM 1.80866354652102 0.0288052135411634 no 141 0.035251644774152 78 2853274 SGTC_3109 9122853 49.47 µM 1.79156580646222 0.0299851782075929 no 142 0.0366012722705549 61 1234709 SGTC_1329 1447-1697 50.6 µM 1.77257003546848 0.0313428525793839 no 143 0.0381499903079729 58 2840515 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.76319087597532 0.0320317229270732 no 144 0.0389341510566821 62 6708784 An antioxidant flavonoid SGTC_2864 9034755 47.6 µM 1.76172419873026 0.032140567866322 no 145 0.0390579536260046 59 4930451 SGTC_842 0271-0008 11.1 µM 1.75732308914313 0.032469016783185 no 146 0.0394313772134828 78 1221709 SGTC_777 1315-0167 517 µM 1.75412525108245 0.032709400033315 no 147 0.0397045238900819 65 4221767 SGTC_3276 9139060 49.47 µM 1.75320085433566 0.0327791602227825 no 148 0.0397837682188254 88 4870619 SGTC_1202 1988-0068 29.6 µM 1.74605065150605 0.0333229085869565 no 149 0.040401075375595 67 2850480 SGTC_1369 1866-0067 208 µM 1.73457510810957 0.034211095937958 no 150 0.0414080458046616 69 3531355 SGTC_415 dibenzyl ketone 100 µM 1.73323810870822 0.0343158315807948 no 151 0.0415266780914625 79 7593 SGTC_1140 3229-1848 2.98 µM 1.73185540085571 0.0344244249011551 no 152 0.041649655610301 56 2849525 SGTC_1910 st062352 60.4 µM 1.73045552345765 0.0345346541475682 no 153 0.0417744605394729 57 2245730 SGTC_2213 7173844 200 µM 1.72855952827393 0.0346844108757669 no 154 0.0419439791583396 68 892728 SGTC_3328 9140624 29.0385 µM 1.72389516259313 0.0350551004715052 no 155 0.0423633853860411 71 4904392 SGTC_2761 levamisole 97.89 µM 1.7234357519308 0.035091786284277 no 156 0.0424048771388123 56 26879 An alkaline phosphatase inhibitor. SGTC_759 3486-0358 89.3 µM 1.71917975750326 0.035433144728961 no 157 0.0427908227580471 84 875103 SGTC_1448 4255-0083 152 µM 1.71466888064796 0.0357979139128739 no 158 0.0432029760705215 89 5399660 SGTC_1829 berberine 14.4 µM 1.7113302987763 0.0360698629426319 no 159 0.0435100780811174 95 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3221 9128209 49.47 µM 1.71032636433894 0.0361519699740329 no 160 0.0436027695792304 67 16460723 SGTC_2280 7785178 200 µM 1.70915686430979 0.0362478107422669 no 161 0.0437109483337638 64 2954328 SGTC_1600 coumarin 106 71.1 µM 1.70530161970566 0.0365652228292665 no 162 0.0440690928369839 69 100336 A hepatotoxic, DNA x-linker. SGTC_2366 9070441 60.58 µM 1.70210855915828 0.0368298340817536 no 163 0.0443675098599735 70 6837235 SGTC_1919 st067113 52.3 µM 1.69226670923252 0.0376553012574987 no 164 0.0452975661360156 87 1268243 SGTC_2299 7976368 114.88 µM 1.68935059258623 0.0379027656075046 no 165 0.0455761316506918 70 2979718 SGTC_3295 9122362 53.5725 µM 1.6891244409733 0.037922012360233 no 166 0.0455977924773216 89 4730473 SGTC_626 0214-0009 33 µM 1.68824930071096 0.0379965667860617 no 167 0.0456816915050822 79 3437874 SGTC_3067 9117431 49.47 µM 1.68773524439199 0.0380404156855272 no 168 0.0457310315173874 106 17150885 SGTC_2285 7945142 200 µM 1.68734514573219 0.0380737185631094 no 169 0.0457685024388498 77 2970608 SGTC_2917 7979103 53.79 µM 1.67954417908355 0.0387446977416312 no 170 0.0465230181382638 75 2980565 SGTC_597 k018-0003 82.8 µM 1.67791238632312 0.0388862631856647 no 171 0.046682102062343 61 6786234 SGTC_2058 5236698 133 µM 1.67451816118165 0.0391820771296292 no 172 0.0470144040949959 68 766665 SGTC_928 2764-0428 58.7 µM 1.67399855792237 0.0392275228958225 no 173 0.0470654413837326 102 662578 SGTC_1314 1222-0010 41.1 µM 1.67197096052208 0.0394052719814885 no 174 0.0472650242654138 69 3526027 SGTC_2320 7373003 200 µM 1.67118989399901 0.039473918678551 no 175 0.0473420878822173 80 5415828 SGTC_1624 st003710 6.25 µM 1.67107623744699 0.039483915875426 no 176 0.047353310147826 68 24207033 SGTC_3036 9090181 49.47 µM 1.66939412568947 0.039632114876682 no 177 0.0475196485330113 66 25236586 SGTC_1749 st037932 54.2 µM 1.66868117995527 0.0396950638387151 no 178 0.0475902904342029 87 594497 SGTC_226 1,3-diallylurea 8.28947 mM 1.6680371713084 0.0397519959209029 no 179 0.0476541740216537 85 74537 YKL182W FAS1 SGTC_2876 9059903 25.97 µM 1.66717660486479 0.0398281758964821 no 180 0.0477396466324399 83 6916095 SGTC_2772 vinpocetine 57.06 µM 1.66488393422724 0.0400317094908267 no 181 0.0479679570219126 75 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2228 7354201 200 µM 1.65705977452349 0.040732677250473 no 182 0.0487536953539366 80 753451 SGTC_628 1636-0253 16 µM 1.6560174077078 0.0408268104135086 no 183 0.0488591468068031 88 4456143 SGTC_621 3584-0052 32.1 µM 1.65515133531559 0.0409051571096484 no 184 0.0489469019273501 84 2273927 SGTC_656 4090-1979 187 µM 1.65172653523996 0.0412161671148153 no 185 0.0492951553827285 78 22330961 SGTC_669 0108-0021 26.2 µM 1.65109274166292 0.041273932312539 no 186 0.0493598195947904 77 17201 SGTC_2132 5317594 122.667 µM 1.64809796286028 0.0415477706556278 no 187 0.0496662851442218 68 794577 SGTC_155 k072-0202 43.6 µM 1.64064904686075 0.042235276283309 no 188 0.050435143755305 86 5857737 SGTC_723 4182-0001 115 µM 1.63600989955981 0.0426680831699298 no 189 0.0509187577721017 72 744821 YLR208W SEC13 SGTC_2734 clemastine 41.6 µM 1.63184157939703 0.0430600162178627 no 190 0.0513564318020721 85 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2868 9035608 32.47 µM 1.62887120086038 0.0433410816512346 no 191 0.051670143929582 74 6462614 SGTC_982 1491-0518 27.5 µM 1.62393029284728 0.0438118837023539 no 192 0.0521953432493179 68 3091256 SGTC_664 1222-0054 14.9 µM 1.62351089372752 0.0438520360273832 no 193 0.0522401182613156 97 6813991 SGTC_407 eburnamonine 100 µM 1.62348381590208 0.0438546294170207 no 194 0.0522430101354453 77 3195 SGTC_3255 9139072 49.47 µM 1.62335305698115 0.0438671546465759 no 195 0.0522569767958182 72 17646060 SGTC_173 1273-0061 2.693 µM 1.61801757157454 0.0443806997765439 no 196 0.0528294054448441 116 2847414 YPL266W DIM1 SGTC_3135 9127742 49.47 µM 1.61553235476617 0.0446215523599242 no 197 0.0530977297714996 75 3643468 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.61208986430205 0.0449569162994322 no 198 0.0534711930083457 118 2346 DNA damaging agent; causes G2/M arrest. SGTC_2254 7938975 95.19 µM 1.61008933758435 0.04515273582743 no 199 0.0536891772262982 82 2969277 SGTC_188 3229-0966 278.469 µM 1.60977454427598 0.0451836114528653 no 200 0.0537235421816636 130 5722370 SGTC_511 blebbistatin 171 µM 1.60930291870118 0.0452299013232193 no 201 0.053775060601708 71 3476986 A myosin inhibitor. SGTC_1833 st055984 71 µM 1.60915275496525 0.0452446478420441 no 202 0.0537914720740694 66 676288 SGTC_2440 5628896 157.78 µM 1.60773971097252 0.0453836024337601 no 203 0.0539460987196631 69 5522048 SGTC_665 3914-0008 307 µM 1.60379984001993 0.0457728511272142 no 204 0.0543790899395419 71 1069549 SGTC_1853 st056710 91.2 µM 1.60340534761682 0.0458119732592827 no 205 0.0544225955854484 92 269167 SGTC_2414 st077232 92.9 µM 1.59716502390121 0.046434413178333 no 206 0.0551144634561646 78 729801 SGTC_1954 st077032 68.9 µM 1.59490925881222 0.0466610776192661 no 207 0.055366264431874 79 698907 SGTC_3136 9095672 49.47 µM 1.59342392566949 0.0468108114330274 no 208 0.0555325609437668 89 17217380 SGTC_2124 5246320 200 µM 1.58184250158998 0.047991574423448 no 209 0.0568427648731499 114 579342 SGTC_2261 9010538 184.68 µM 1.58177352158283 0.0479986779137312 no 210 0.0568506408709822 83 6457250 SGTC_1763 st044482 94.5 µM 1.58092163781329 0.0480864734176836 no 211 0.0569479780988419 93 88505 SGTC_101 0490-5701 117.494 µM 1.57720167844754 0.0484713608872415 no 212 0.0573745634606494 64 4661669 SGTC_1386 3228-0095 33.8 µM 1.57375316131548 0.0488303601733924 no 213 0.0577722631820797 75 870181 SGTC_1112 tnp00069 1.16933 µM 1.57101355519083 0.0491170719509897 no 214 0.0580897501125194 77 145826 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.55984354634079 0.0503000055655406 no 215 0.0593984289920105 104 688788 SGTC_2943 9068529 45.32 µM 1.5596463900994 0.0503210870756926 no 216 0.0594217337094222 114 3270634 SGTC_2259 7964009 200 µM 1.5519579415119 0.0511487026369648 no 217 0.0603361437326628 72 313134 SGTC_2520 obtusaquinone 4.71 µM 1.55148190444941 0.051200299167631 no 218 0.0603931202857562 103 5967872 SGTC_86 0417-1630 471.922 µM 1.54529924589301 0.0518741913989012 no 219 0.0611369488999752 139 3634867 SGTC_3026 9090633 49.47 µM 1.54513436627725 0.0518922588402427 no 220 0.0611568829551737 77 25236842 SGTC_3308 9128332 17.569 µM 1.5372026251513 0.0527673378384173 no 221 0.0621218488494679 99 17332805 YDL196W YDL196W SGTC_562 3772-2733 112 µM 1.52880907267523 0.0537060747577249 no 222 0.0631558912818294 86 2876874 YIL048W NEO1 SGTC_236 1509-0011 5.31 µM 1.52600760933391 0.0540223187876034 no 223 0.0635039847269352 143 3107280 SGTC_3035 9091303 49.47 µM 1.52518042122085 0.0541159775126068 no 224 0.063607051296764 82 25237002 SGTC_2591 skatole 100 µM 1.52506683017483 0.0541288489363675 no 225 0.0636212147525837 104 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2642 cholecalciferol 100 µM 1.51980386305698 0.0547278765716139 no 226 0.064280138970902 71 9821465 A vitamin D precursor, similar to steriods. SGTC_1358 1509-0022 2.48 µM 1.51646459725784 0.0551106592219211 no 227 0.0647009578578261 103 3258434 SGTC_2762 leflunomide 42.06 µM 1.50922546646002 0.0559477480925668 no 228 0.0656205871615658 114 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1603 st002045 67.8 µM 1.50851316232355 0.0560306536928146 no 229 0.0657116202607786 74 5887985 SGTC_2572 astragaloside iv 100 µM 1.50243835823023 0.0567416472380478 no 230 0.0664919681260839 103 45006101 An anti-inflammatory agent. SGTC_3102 9121669 49.47 µM 1.50217638800757 0.0567724672768624 no 231 0.0665257805596572 104 41905072 SGTC_3302 9125395 16.351 µM 1.50191791217754 0.0568028891319175 no 232 0.0665591550163749 86 17599668 SGTC_1928 4'-methoxychalcone 40.3 µM 1.50037821052585 0.0569843736670064 no 233 0.0667582302443934 112 641818 SGTC_895 0964-0006 13.7 µM 1.49875944343258 0.0571756696258637 no 234 0.0669680247180583 128 6738897 SGTC_1242 0402-0103 60.1 µM 1.49539974512001 0.0575743110523688 no 235 0.0674050735165002 91 432868 SGTC_1412 3909-8563 178 µM 1.49520215139951 0.0575978242193749 no 236 0.0674308461190711 94 23767530 SGTC_1433 4060-0023 7.6 µM 1.49391010768258 0.0577517604461475 no 237 0.0675995581092229 103 3840627 SGTC_877 0771-0151 33.1 µM 1.48896000095973 0.0583445198886026 no 238 0.0682489509736962 94 6166523 SGTC_2023 5144124 124 µM 1.48872374622853 0.0583729296715518 no 239 0.0682800646352127 97 2830192 SGTC_2470 5664817 21.68 µM 1.47394904433117 0.0601712803463777 no 240 0.070247655648969 87 2859561 SGTC_435 c-PAF 6.7 µM 1.47342651982167 0.0602356664391264 no 241 0.0703180318766721 105 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_507 nimesulide 162 µM 1.47077382089951 0.06056336738912 no 242 0.0706761472531307 96 4495 A COX2 inhibitor. SGTC_452 diindolylmethane 8 µM 1.46800884221147 0.060906421632146 no 243 0.0710509105429695 82 3071 Inhibits expression of several cancer promoting factors. SGTC_2989 9073649 71.4286 µM 1.46672597096299 0.0610661041206935 no 244 0.0712253074890944 120 21367202 SGTC_512 prima-1 270 µM 1.46200521869988 0.061656528018406 no 245 0.0718698898956371 89 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1677 st019204 53.9 µM 1.46192557213962 0.061666527503682 no 246 0.0718808032685294 89 3945625 SGTC_1116 jasmonic acid  1.58368 µM 1.46059209071831 0.0618341318795575 no 247 0.072063709070309 93 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_254 nsc-64875 3.808 µM 1.4587604667878 0.0620649268165491 no 248 0.0723155235063946 81 56993 SGTC_1738 st035555 74 µM 1.44553172404267 0.0637518331002536 no 249 0.0741542943947135 114 5331140 SGTC_2724 maprotiline 69.64 µM 1.43978215023181 0.0644960371822986 no 250 0.0749645213889275 103 4011 A tricyclic antidepressant. SGTC_646 4092-0839 27.3 µM 1.43687927438437 0.0648743301260504 no 251 0.0753761499612332 117 877796 SGTC_1657 st012939 43.4 µM 1.42850711240189 0.0659750132016 no 252 0.07657297446244 75 24207257 SGTC_591 4299-0174 154 µM 1.42644759577125 0.066247981770311 no 253 0.0768695916690607 93 5509088 SGTC_2347 9049783 174.81 µM 1.42151498010835 0.066905307037247 no 254 0.0775835508857612 107 6467988 YPL169C MEX67 SGTC_2120 5538279 151.968 µM 1.4195062356324 0.0671744355968898 no 255 0.0778757401073237 91 2058197 SGTC_2281 7943571 200 µM 1.41942742801552 0.0671850111621518 no 256 0.0778872203562805 112 1244024 SGTC_524 r073-0010 27.8 µM 1.41427209809613 0.0678796297390751 no 257 0.0786410130221183 121 2772106 SGTC_228 caffeine 993.056 µM 1.41319983465611 0.0680247986107938 no 258 0.0787984875757632 65 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2155 5570423 76 µM 1.41182913569527 0.068210720221311 no 259 0.0790001386882852 106 797402 SGTC_1956 st077085 54 µM 1.40920804877872 0.0685673362063587 no 260 0.0793868292398883 133 24208685 SGTC_266 formosanin C 406 nM 1.40878034825102 0.0686256638873135 no 261 0.0794500638890799 135 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1913 st060213 96.1 µM 1.40597383095016 0.0690093526886967 no 262 0.0798659478375913 109 688959 SGTC_2090 5301565 104.445 µM 1.40565275835508 0.0690533528351574 no 263 0.0799136307551715 120 2056344 SGTC_2185 6113692 200 µM 1.40154910215319 0.0696176282929844 no 264 0.0805249675177871 109 874150 SGTC_2987 9018338 71.43 µM 1.40028956606467 0.0697915316239774 no 265 0.0807133120282891 135 5055682 SGTC_1148 3909-7663 27.7 µM 1.39688970512555 0.0702626175845155 no 266 0.0812233704402254 97 4084526 SGTC_2266 7929956 200 µM 1.38336064437043 0.0721614648488932 no 267 0.0832771557798572 115 2967153 SGTC_1596 piperlongumine 63 µM 1.38229570358627 0.0723125866939114 no 268 0.0834404623292036 98 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_740 k014-0057 261 µM 1.38197938013624 0.0723575216800529 no 269 0.0834890162351933 120 4012779 SGTC_1027 k015-0025 8.67 µM 1.3816106668798 0.072409925843785 no 270 0.0835456384835 120 3598955 SGTC_2312 7706453 155.7 µM 1.380107454417 0.0726238741164662 no 271 0.083776781218097 119 976098 SGTC_2716 st080858 38.6235 µM 1.37628059936806 0.0731707252988041 no 272 0.0843673884631741 101 5296050 SGTC_2325 6158266 200 µM 1.37487355303183 0.0733725801400736 no 273 0.0845853248863242 103 3623240 SGTC_2622 2-methoxyxanthone 59.94 µM 1.37350343510663 0.0735695462638744 no 274 0.0847979470305456 108 71034 A hepatoprotective. SGTC_2485 5633444 17.78 µM 1.37052898079316 0.0739985406602464 no 275 0.0852609175743499 114 5724239 SGTC_557 1315-0110 16.2 µM 1.36961641915859 0.0741305384097526 no 276 0.0854033357350036 106 6833801 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.36914730175232 0.0741984639928931 no 277 0.0854766174559968 106 115019 SGTC_1837 st055472 66.5 µM 1.36748214585242 0.0744399531476798 no 278 0.0857371148891201 102 676091 SGTC_3309 9129340 25.759 µM 1.36742920526922 0.0744476406834188 no 279 0.0857454066650151 98 17158987 SGTC_3291 9121177 71.43 µM 1.3661888286049 0.0746279300739567 no 280 0.0859398514910572 93 17015612 SGTC_1627 st003713 25.6 µM 1.36616665714874 0.074631155735227 no 281 0.0859433301482576 110 16195070 YER133W GLC7 SGTC_1807 st050092 58.9 µM 1.36285355048928 0.075114367046849 no 282 0.0864643350996196 120 5008496 SGTC_2222 6885208 172.143 µM 1.36021988112564 0.0755001826313335 no 283 0.0868801765037047 95 609514 SGTC_1211 1056-0033 32.3 µM 1.35176081064293 0.0767495991715544 no 284 0.0882259222988152 107 6741922 SGTC_359 0081-0058 15.9 µM 1.35171910864026 0.0767557973243334 no 285 0.0882325949026308 128 3494159 SGTC_1706 st031321 9.9705 µM 1.34838111773896 0.0772531571419803 no 286 0.0887679169765408 118 6103185 SGTC_2307 7538926 6.34 µM 1.34702324570044 0.0774561788838664 no 287 0.088986373063646 140 96582 SGTC_814 3342-0569 96 µM 1.34694378820098 0.0774680714800163 no 288 0.0889991686647778 121 4346283 SGTC_828 2074-0507 139 µM 1.34121377810476 0.0783293566783544 no 289 0.089925527114264 119 X828 SGTC_3239 9133757 49.47 µM 1.33759086444081 0.0788776564598446 no 290 0.0905149220467631 103 17036923 SGTC_1071 trifluoperazine 6.31 µM 1.33513767537707 0.0792505752603616 no 291 0.0909156453004813 117 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2759 disulfiram 3.38 µM 1.33460609726734 0.0793315581861082 no 292 0.091002650697154 137 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1564 D-Arginine 115 µM 1.33420732695818 0.0793923497028089 no 293 0.0910679594730122 148 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2659 sanguinarine 24.21 µM 1.33265391503359 0.0796294996265865 no 294 0.0913227016509863 114 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1889 st059080 5.18 µM 1.33259925252764 0.0796378543688495 no 295 0.0913316753026136 99 176925 Isolated from Daphnopsis sellowiana. SGTC_1492 4158-0558 28.5 µM 1.33252467008367 0.0796492547896681 no 296 0.0913439201584941 106 3967268 SGTC_2355 9061122 103.12 µM 1.33050962101687 0.0799577359150877 no 297 0.091675209278337 127 5302957 SGTC_1568 digitonin 820 nM 1.33032677243408 0.0799857726022447 no 298 0.0917053149497402 146 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1780 st038448 24.544 µM 1.32637827754584 0.080593021275515 no 299 0.0923572151560721 120 728868 YDL195W SEC31 SGTC_2399 5884133 200 µM 1.32626571815316 0.0806103829663713 no 300 0.0923758489621758 126 722445 SGTC_1964 st076914 61 µM 1.32428512242961 0.0809163417326245 no 301 0.0927041848292732 150 24208661 SGTC_2098 5376439 882.5 nM 1.32277398847568 0.0811503678774868 no 302 0.0929552749464025 109 2844116 SGTC_1523 st012844 44.7 µM 1.32135094389116 0.0813712184147278 no 303 0.0931921874468655 93 4274103 SGTC_1370 2001-0092 44.6 µM 1.32098937898924 0.0814274039301107 no 304 0.0932524528222951 131 790957 SGTC_1396 3511-0007 98.6 µM 1.32031612768227 0.0815321020329939 no 305 0.0933647465836005 120 X1396 SGTC_1382 3002-2117 298 µM 1.31863749341199 0.0817935904811517 no 306 0.0936451664027707 125 1497314 SGTC_2723 salbutamol 83.58 µM 1.31764116957239 0.081949090999287 no 307 0.093811898479575 109 9884233 β2-adrenoceptor agonist SGTC_3169 9102970 49.47 µM 1.31641951692749 0.0821400634548309 no 308 0.0940166376639905 110 17027839 SGTC_323 4013-0906 34.3 µM 1.31615647171367 0.0821812273107582 no 309 0.094060765039953 105 2910086 SGTC_79 0052-0007 94.094 µM 1.31386739447416 0.0825401004148729 no 310 0.0944454164505349 117 2801472 SGTC_1139 k015-0024 46.9 µM 1.30563256681951 0.083840884612454 no 311 0.0958387699309552 117 2766652 SGTC_2739 tacrine 100.86 µM 1.30545137055146 0.083869678742171 no 312 0.0958695978995568 112 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1053 3366-3204 134 µM 1.30206392294661 0.0844093504970559 no 313 0.0964472673375655 133 3632071 YPR165W RHO1 SGTC_378 3970-0959 8.33 µM 1.30092131783056 0.0845919712392209 no 314 0.0966426941811752 140 6615653 SGTC_156 3474-0145 5.642 µM 1.29763553284992 0.0851187843930679 no 315 0.097206302998494 118 2265471 SGTC_1360 1598-0022 39.8 µM 1.29661910119775 0.0852822467806839 no 316 0.0973811384492697 144 761525 SGTC_1235 benzylparaben 21.5 µM 1.2950006610205 0.0855430092880968 no 317 0.0976600007258892 121 7180 SGTC_703 3875-0075 71.8 µM 1.29366412589241 0.0857588011092716 no 318 0.0978907309491952 149 2850814 SGTC_3157 9099274 49.47 µM 1.29276663730552 0.0859039346852318 no 319 0.0980458912655535 120 17217662 SGTC_1453 4237-0541 195 µM 1.29203621670807 0.0860221871774464 no 320 0.0981723013532873 132 739892 SGTC_2905 7799065 20.05 µM 1.2909377208171 0.0862002590146911 no 321 0.0983626370535029 124 1296806 SGTC_216 k038-0035 28.382 µM 1.29041888451322 0.0862844608572304 no 322 0.0984526294029362 147 4444231 YPR107C YTH1 SGTC_1316 1272-0050 65.9 µM 1.28983024581712 0.0863800653828664 no 323 0.0985548019841108 128 7340392 SGTC_3125 9127534 49.47 µM 1.28948245237643 0.0864365899251082 no 324 0.0986152064755082 101 1639235 SGTC_1334 1486-0610 236 µM 1.28904292213007 0.0865080633905913 no 325 0.0986915825028313 131 3742339 SGTC_165 k038-0023 64.381 µM 1.28875905328911 0.0865542477175734 no 326 0.0987409326572468 134 46368543 SGTC_3335 9143315 29.6265 µM 1.28460106508192 0.0872328495298581 no 327 0.0994658631541491 114 4899691 SGTC_531 3788-1495 174 µM 1.28197468729541 0.0876635281785176 no 328 0.0999257629701654 106 2896655 SGTC_2028 5153890 36.43 µM 1.28053789549653 0.0878998064723286 no 329 0.100178012972751 131 2830968 YPR165W RHO1 SGTC_3025 9087895 49.47 µM 1.27954456392209 0.0880634358528428 no 330 0.100352678563937 127 17173641 SGTC_2512 diallyl trisulfide 49.23 µM 1.27750243134069 0.0884005451692265 no 331 0.100712461298412 149 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3264 9137442 49.47 µM 1.2760847391847 0.0886351385349684 no 332 0.100962782819542 123 17015726 SGTC_1655 st012546 55.1 µM 1.27487184481667 0.088836210673344 no 333 0.101177303016114 106 720985 YLR208W SEC13 SGTC_1757 st041620 31.8375 µM 1.274610016624 0.08887966076643 no 334 0.101223655171061 107 5289815 SGTC_2419 paclitaxel 166.5 µM 1.27165338173277 0.089371409592069 no 335 0.101748150525535 141 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2813 7971799 71.43 µM 1.2576254616593 0.0917321441422124 no 336 0.104263620316694 136 2234054 SGTC_729 4092-0585 94.1 µM 1.25600284397113 0.0920081650713402 no 337 0.10455746948539 121 2169061 SGTC_54 0159-0055 9 µM 1.25424585380911 0.0923077368729971 no 338 0.104876328952606 126 3319099 SGTC_1033 k072-0102 21.3 µM 1.25111159451785 0.0928439283954546 no 339 0.105446882976899 137 5965931 SGTC_1646 st011709 75.6 µM 1.25092060699408 0.0928766757572937 no 340 0.105481722376919 141 5757843 SGTC_809 3998-0021 90 µM 1.24875019842024 0.0932494214398034 no 341 0.105878227127336 149 715485 SGTC_1336 1486-0901 104 µM 1.24843184745147 0.0933041878172962 no 342 0.105936476082048 125 5006114 SGTC_2721 ifenprodil 61.44 µM 1.24812778069338 0.0933565190462872 no 343 0.105992133062131 129 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3000 9075062 71.4286 µM 1.24778336770597 0.0934158202248352 no 344 0.106055200613384 128 17057871 SGTC_966 1300-0360 30.2 µM 1.24773452332889 0.0934242325233689 no 345 0.106064146998381 163 70588 SGTC_1632 st005650 90 µM 1.24714050668183 0.0935265827472522 no 346 0.106172991322512 129 2759605 SGTC_2529 gangaleoidin 93.61 µM 1.247070896857 0.0935385820740485 no 347 0.106185751521469 118 4565183 SGTC_2676 harmalol 100 µM 1.24516222367595 0.0938680418746402 no 348 0.106536062727625 130 5459187 A monoamine oxidase inhibitor SGTC_2735 sertaconazole 140 nM 1.24476117752682 0.0939373759897153 no 349 0.106609775284159 140 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1305 1181-0477 144 µM 1.23937912472035 0.0948715018981132 no 350 0.107602564264853 147 6252086 SGTC_471 1-acyl-paf 4 µM 1.23800233801112 0.0951115569560105 no 351 0.107857596955737 126 16759367 SGTC_1821 st053465 65.6 µM 1.23531772565795 0.0955809291663564 no 352 0.108356139649463 113 675086 SGTC_3288 9119690 36.221 µM 1.23446389625137 0.0957305676680913 no 353 0.108515046032198 158 17595618 YKL019W RAM2 SGTC_1130 3454-2858 15.9 µM 1.23101099424912 0.0963374664958235 no 354 0.109159376173806 166 715628 YIL048W NEO1 SGTC_3121 9125696 49.47 µM 1.22900314599696 0.0966916733232543 no 355 0.109535313244047 113 1235365 SGTC_2242 6630449 61.2675 µM 1.22811125867039 0.0968493186426781 no 356 0.109702602584881 123 691249 YDR170C SEC7 SGTC_2303 7774051 200 µM 1.21977977504956 0.0983310719308309 no 357 0.111274185188118 137 2953184 SGTC_2875 9039966 71.43 µM 1.21837024953171 0.0985833892198475 no 358 0.111541652665434 123 6463691 SGTC_972 1319-0219 195 µM 1.2148728358215 0.0992115029714094 no 359 0.112207297839474 150 23903702 SGTC_1181 1222-0449 220 µM 1.21457785783928 0.0992646126967385 no 360 0.112263569067184 139 658318 SGTC_1192 1488-0095 21.4 µM 1.21027188898535 0.100042254776313 no 361 0.113087290361597 131 915875 SGTC_2768 sulfasalazine 50.2 µM 1.20883784431604 0.100302222797165 no 362 0.113362574608673 130 5384001 An antioxidant and salicylic acid derivative. SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.20869474263712 0.100328191739187 no 363 0.113390071113793 127 140250 A respiratory chain inhibitor. SGTC_201 4262-0159 12.803 µM 1.20869017577274 0.100329020577803 no 364 0.113390948699703 129 1341029 SGTC_1408 3909-7976 48.8 µM 1.20825253871832 0.100408470359772 no 365 0.11347506916514 135 24152374 SGTC_1859 st055998 20 µM 1.20727411949157 0.10058626119723 no 366 0.113663297089272 133 676301 SGTC_2412 st077135 33.4 µM 1.20562354308422 0.100886711581745 no 367 0.113981338619013 145 13258915 SGTC_639 0833-0042 114 µM 1.2024588438385 0.1014646030206 no 368 0.114592901243841 151 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2777 climbazole 1.536 µM 1.20232793807934 0.101488558951886 no 369 0.11461824834073 147 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2624 nerol 100 µM 1.19898156741766 0.102102348630108 no 370 0.115267556488604 144 637566 A natural product oil. SGTC_1990 st072050 59.8 µM 1.1982699703777 0.102233216907086 no 371 0.115405966642276 139 17233948 SGTC_1958 st076513 41.9 µM 1.19024780588095 0.103717004055973 no 372 0.116974504267946 153 732122 YGL099W LSG1 SGTC_1491 4138-0063 26.5 µM 1.18985685328848 0.103789712207258 no 373 0.117051329682311 131 23883227 SGTC_558 k064-0027 21.3 µM 1.18832481254854 0.104074992733106 no 374 0.117352732895017 155 5088526 SGTC_2077 5212015 200 µM 1.18667461684448 0.104382910355889 no 375 0.117677995507845 138 780900 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.18410652048452 0.104863415514737 no 376 0.118185449659589 137 15053 SGTC_152 4469-0003 551.229 µM 1.18263307918204 0.105139826590848 no 377 0.118477298333347 172 697280 SGTC_2029 5175081 200 µM 1.18067069175099 0.105508780028741 no 378 0.118866784375435 131 1380876 SGTC_574 1315-0397 40 µM 1.17869095947882 0.105881942411062 no 379 0.119260628419646 176 6794277 SGTC_1170 0310-0127 64.8 µM 1.17805457660451 0.106002097421911 no 380 0.119387424568403 164 774975 SGTC_3046 9092212 49.47 µM 1.17436834913212 0.106700030053341 no 381 0.120123758575718 139 25236637 SGTC_2404 5161160 200 µM 1.17417931725945 0.106735909625772 no 382 0.120161604284117 186 2831543 SGTC_655 k060-0012 42 µM 1.17284135840918 0.106990112508367 no 383 0.120429714654088 168 5994525 SGTC_709 3807-1509 243 µM 1.17179498267546 0.107189220727365 no 384 0.120639688783019 171 1886677 YPL242C IQG1 SGTC_683 panaxydol 45 µM 1.17068269741769 0.107401163267787 no 385 0.120863171312791 117 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3140 9094243 49.47 µM 1.17051604746489 0.10743294390603 no 386 0.120896680027426 183 19291112 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.16934947929629 0.107655601709297 no 387 0.121131427811992 135 2724 A muscle relaxant with antifungal properties. SGTC_470 aa-861 153 µM 1.16560135529655 0.108373239651497 no 388 0.121887829812331 155 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1822 st052468 42 µM 1.16538983102297 0.108413841707998 no 389 0.121930615824865 145 2873678 SGTC_1350 1495-0454 146 µM 1.15864119844479 0.109714990899463 no 390 0.123301234199866 147 1069057 SGTC_2511 berberine 10.47 µM 1.15627874886696 0.110173114142228 no 391 0.123783578930364 160 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_929 2805-0021 398 µM 1.15487361506824 0.110446245822722 no 392 0.124071092812815 166 3098024 SGTC_2784 7567673 72.73 µM 1.15147829268981 0.111108235820769 no 393 0.124767760295235 151 3471247 SGTC_2940 9060638 45.86 µM 1.14776238910545 0.111835981001467 no 394 0.12553333388334 135 4027022 SGTC_596 1155-0152 116 µM 1.14751681137641 0.11188419625241 no 395 0.125584044569153 162 280313 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.14559268194693 0.112262482792587 no 396 0.125981863327998 150 551469 SGTC_2649 anisomycin 9.56 µM 1.14471394952044 0.11243554651726 no 397 0.126163835516171 154 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3031 9088762 49.47 µM 1.14465422642277 0.112447315716488 no 398 0.126176209911902 150 205253 SGTC_3037 9091026 49.47 µM 1.14376163296594 0.112623317538442 no 399 0.12636125264823 153 25236398 YIL048W NEO1 SGTC_1760 st045453 10.4495 µM 1.14320602346555 0.112732972070881 no 400 0.126476530987799 164 3323419 YIL048W NEO1 SGTC_1844 rapamycin 4 nM 1.14198268799038 0.112974676994303 no 401 0.126730607882989 183 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2690 usnic acid 100 µM 1.14182779964156 0.113005305979409 no 402 0.12676280227259 138 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2686 alizarin 95.37 µM 1.14078772431062 0.113211133150182 no 403 0.126979135123875 129 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1183 1254-0324 198 µM 1.14030567529586 0.11330661957256 no 404 0.127079487111478 131 5799357 SGTC_2119 5528445 120.635 µM 1.1392152434766 0.113522829103185 no 405 0.127306694587299 144 791935 SGTC_2464 5717415 7.67 µM 1.13912639380186 0.113540459064383 no 406 0.127325220163668 149 5285744 SGTC_1560 lithocholic acid 53.1 µM 1.13842079714413 0.113680536112987 no 407 0.127472406972737 130 9903 A bile acid which acts as a detergent. SGTC_2437 5741531 144.16 µM 1.13828936970537 0.113706641064951 no 408 0.12749983568128 172 2262990 SGTC_2371 9071574 200 µM 1.13741551461281 0.113880320370621 no 409 0.127682312282083 163 45596039 SGTC_1482 3346-2049 8.48 µM 1.13517961763926 0.114325566859745 no 410 0.128150033862402 140 3826804 SGTC_1436 4092-1007 8.32 µM 1.13329597069654 0.114701628714968 no 411 0.128544991638076 125 2881121 SGTC_1298 1079-1278 263 µM 1.13097209371775 0.115166792300535 no 412 0.129033418616067 157 2840950 SGTC_2227 7312221 64.1025 µM 1.12531466541283 0.11630482573407 no 413 0.130227858684892 179 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1111 tnp00062 510.699 nM 1.12529051862398 0.116309700078683 no 414 0.130232973083967 147 676306 SGTC_3163 9099914 49.47 µM 1.12439113977052 0.116491354691719 no 415 0.130423564583631 177 16268368 SGTC_1219 1469-0211 33.1 µM 1.12416567919705 0.116536924264314 no 416 0.130471373196055 167 6822282 SGTC_659 k018-0002 107 µM 1.12239565436055 0.116895116885135 no 417 0.130847125676593 151 6797879 YHR007C ERG11 SGTC_516 3992-2719 87.3 µM 1.11965524345618 0.117451220640954 no 418 0.131430352207612 119 5350887 YDR037W KRS1 SGTC_617 3770-0098 35 µM 1.11809713906345 0.117768236349431 no 419 0.131762754099676 152 5962639 SGTC_662 k832-1615 104 µM 1.11479114153932 0.118442886958349 no 420 0.132469966714806 150 5878478 SGTC_663 1486-0733 13.9 µM 1.11457129770543 0.118487846874234 no 421 0.132517087858214 160 722445 YPR165W RHO1 SGTC_1640 st009078 66.4 µM 1.11422106362604 0.118559497605625 no 422 0.132592180589991 162 690618 SGTC_2850 9015429 58.44 µM 1.11369353320649 0.118667477325471 no 423 0.132705342267362 168 6457570 SGTC_785 1270-0111 65.3 µM 1.11233711483441 0.118945440329901 no 424 0.132996615824429 156 6741994 SGTC_1548 st061468 90.8 µM 1.11131878075977 0.119154423617001 no 425 0.133215579115514 137 390799 SGTC_3085 9117376 49.47 µM 1.1083930780726 0.119756280182393 no 426 0.133846046499185 174 16480349 SGTC_1182 1222-0449 220 µM 1.10821872858989 0.119792213784965 no 427 0.133883682169738 146 658318 SGTC_883 0850-0245 24.6 µM 1.10783579606171 0.119871163246101 no 428 0.133966368811968 183 6823229 YPR165W RHO1 SGTC_3052 9092717 49.47 µM 1.09991238700893 0.121512975334546 no 429 0.135685148546961 156 25237534 SGTC_3126 9127922 49.47 µM 1.09568550926331 0.12239526477463 no 430 0.136608213157053 209 45595682 SGTC_2849 9019321 12.99 µM 1.09459111589184 0.122624431843348 no 431 0.136847904734993 155 16489627 SGTC_193 1273-0060 1.558 µM 1.0942137117549 0.122703530404969 no 432 0.136930629560198 164 2847393 YHR072W ERG7 SGTC_1261 0712-0010 12.7 µM 1.09171307865505 0.123228531871731 no 433 0.137479617374228 168 2840123 SGTC_2722 naftopidil 47.16 µM 1.0915234677382 0.12326840430123 no 434 0.137521305669746 151 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2216 7189485 200 µM 1.09092269049368 0.123394798750603 no 435 0.1376534509321 154 731273 SGTC_2732 terfenadine 20 µM 1.09060937797467 0.123460750976694 no 436 0.137722400638948 186 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1486 3970-0793 4.53 µM 1.0902040011756 0.123546119351809 no 437 0.137811645612151 180 2844330 SGTC_950 1165-0508 94.1 µM 1.08932200895506 0.123732001060424 no 438 0.138005955259113 158 6148369 SGTC_37 0566-0070 1.56 µM 1.08923623514001 0.123750088513033 no 439 0.138024861852886 154 1626686 SGTC_2497 7-hydroxyflavone 100 µM 1.08895095931626 0.123810259033938 no 440 0.138087756153575 181 5281894 SGTC_337 1315-0038 354 µM 1.08556322729035 0.124526367142796 no 441 0.138836138135011 141 1626437 SGTC_1546 5-methoxyflavanone 78.7 µM 1.08430912433379 0.124792195839382 no 442 0.139113880529607 145 147795 SGTC_1672 st016598 6.51 µM 1.08342233916928 0.124980404381894 no 443 0.139310502265123 170 4665860 YNL267W PIK1 SGTC_1347 1493-0251 600 nM 1.08165887206224 0.125355266190174 no 444 0.139702067255462 158 3986378 SGTC_761 k216-0224 480 µM 1.07722160290965 0.126301970409277 no 445 0.140690638189833 178 1340404 SGTC_1725 st036284 20.55 µM 1.07502015874951 0.126773499442268 no 446 0.141182851551318 158 707914 SGTC_1023 4482-3888 16 µM 1.07360767363015 0.12707668546791 no 447 0.141499278439012 180 3303168 SGTC_1880 MG-132 525 µM 1.07350334741837 0.127099098794603 no 448 0.141522668785444 176 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2134 5324836 1.464 µM 1.07153917104301 0.12752159375412 no 449 0.141963533850739 160 699272 SGTC_1996 st072960 66.8 µM 1.07139357642229 0.12755295003364 no 450 0.141996249958916 168 1719405 SGTC_922 1866-0035 480 µM 1.07048007068431 0.127749811378981 no 451 0.142201637428152 181 3156169 SGTC_526 4469-0568 170 µM 1.06984525401368 0.127886739272395 no 452 0.142344484360933 159 2901964 SGTC_2588 indole-3-carbinol 100 µM 1.06954149375373 0.12795229543541 no 453 0.142412871055509 166 3712 Induces cell cycle arrest. SGTC_3175 9106517 49.47 µM 1.0691644876849 0.128033691644147 no 454 0.142497778760532 168 41468073 SGTC_3293 9120939 62.045 µM 1.0680472469849 0.128275116904737 no 455 0.142749600004908 163 934087 SGTC_2337 9009472 200 µM 1.06706428587966 0.128487786851905 no 456 0.142971403840359 158 5742383 SGTC_2918 7977171 22.06 µM 1.06170813317186 0.12965092440529 no 457 0.144184102972605 170 2236483 SGTC_555 4296-0685 37 µM 1.05804238680762 0.130451166219578 no 458 0.145018059263943 189 2908540 YHR072W ERG7 SGTC_2818 7996756 12.99 µM 1.05754148537451 0.130560779004066 no 459 0.145132265844592 178 2241621 SGTC_698 k064-0052 127 µM 1.05307266714498 0.131541514029073 no 460 0.146153844410149 177 5088751 SGTC_3134 9127454 49.47 µM 1.05144934619742 0.131899026895436 no 461 0.146526131075405 157 24262820 SGTC_847 0342-0274 5.54 µM 1.05091145285177 0.132017637797941 no 462 0.146649629901423 188 18097 SGTC_2245 6637752 200 µM 1.04887354275695 0.132467684675235 no 463 0.147118161925775 165 681890 SGTC_3074 9116018 49.47 µM 1.04884877849261 0.132473160045825 no 464 0.147123861595667 192 17027303 SGTC_682 0kpi-0099 17 µM 1.04784306497305 0.132695654745467 no 465 0.147355458741855 203 1714895 YML126C ERG13 SGTC_866 0495-0101 262 µM 1.04644766800858 0.133004785483236 no 466 0.147677197202493 162 635694 SGTC_2009 4012297 12.05 µM 1.04616908905595 0.133066560082939 no 467 0.147741485805424 160 45595307 SGTC_1157 4092-0394 27.6 µM 1.04603252465859 0.133096850311709 no 468 0.147773008075948 152 3659885 SGTC_1865 st057639 52.2 µM 1.04284990209547 0.133804105950427 no 469 0.148508907621443 189 688818 SGTC_158 k038-0087 26.446 µM 1.04048758250574 0.134330737965313 no 470 0.149056715092238 178 X158 SGTC_2271 7849410 118.62 µM 1.04046515636578 0.1343357442366 no 471 0.149061922036502 187 972430 SGTC_1977 st070720 65.3 µM 1.03976469137709 0.13449217616157 no 472 0.14922461850772 144 682188 SGTC_83 0170-0301 39.027 µM 1.03970340155953 0.134505869708341 no 473 0.14923885988676 153 3089716 SGTC_112 phenothiazine 287.218 µM 1.03902487176901 0.134657532732667 no 474 0.149396584561617 170 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_280 3448-3607 3.04 µM 1.03879723051808 0.134708440731251 no 475 0.149449524832299 136 626179 SGTC_3325 9138760 55.175 µM 1.0387502832992 0.134718941301129 no 476 0.149460444439248 148 43844959 SGTC_467 ro 31-8220 72.8 µM 1.03734365474349 0.135033819027134 no 477 0.149787863782023 177 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2528 xanthyletin 44.79 µM 1.02950381704841 0.136798031830645 no 478 0.151621493516546 175 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2188 6126565 140.678 µM 1.02874656795114 0.136969267604121 no 479 0.151799390456765 169 874518 SGTC_39 0986-0283 58.349 µM 1.02858603608836 0.137005587278734 no 480 0.151837121256545 163 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1563 conessine 56.1 µM 1.02724924923702 0.137308285379411 no 481 0.15215155653789 141 441082 An anti-amoebic, histamine inhibitor. SGTC_3079 9117512 49.47 µM 1.0246693863859 0.137893752434232 no 482 0.152759606308699 212 7185044 SGTC_518 1021-0119 62.6 µM 1.02157906479029 0.138597300418646 no 483 0.153490085200808 191 1097762 SGTC_3184 9108758 49.47 µM 1.02042322013103 0.138861069338271 no 484 0.153763893018527 181 902885 SGTC_2719 novobiocin 32.65 µM 1.01920942704053 0.139138430098471 no 485 0.154051776069096 178 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3319 9138450 16.7555 µM 1.01919040209056 0.139142780440423 no 486 0.154056291174393 168 2029690 SGTC_2231 micatex 6.853 µM 1.01802889947428 0.139408550907011 no 487 0.154332111170043 184 20737 An antifungal of unknown mechanism. SGTC_1635 st007035 42.4 µM 1.01590866110466 0.139894585562695 no 488 0.154836442031086 181 3716403 SGTC_3088 9117578 49.47 µM 1.01559251394917 0.139967156372572 no 489 0.154911735592549 189 678341 SGTC_2097 5376186 200 µM 1.01512221947937 0.140075158650219 no 490 0.155023785593195 175 742755 SGTC_191 3914-0123 66.505 µM 1.01397521257129 0.140338804116658 no 491 0.155297290088969 188 3144412 SGTC_1008 4106-0037 6 µM 1.00786523625627 0.141748890330673 no 492 0.156759581328355 201 2905394 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.00095557847733 0.14335505563916 no 493 0.158424142390337 200 5282309 SGTC_255 tunicamycin 200.472 nM 1.00069897311894 0.143414939859188 no 494 0.158486182008466 180 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3269 9137823 49.47 µM 0.997826810810285 0.144086371418377 no 495 0.159181673477531 143 17682936 SGTC_1628 st004252 77.7 µM 0.994894553818177 0.144774034813703 no 496 0.159893775983078 174 692968 SGTC_2998 9066762 71.4286 µM 0.993708882455427 0.145052721133145 no 497 0.160182308548147 172 4945196 SGTC_906 1165-0455 526 µM 0.992930522554283 0.145235867065582 no 498 0.160371907007849 188 3252859 SGTC_345 1362-0200 395 µM 0.991628013849679 0.14554269166232 no 499 0.160689509269133 177 1419823 SGTC_2482 5981709 142.65 µM 0.991119431949095 0.145662613661822 no 500 0.160813632740001 198 877755 SGTC_1383 3049-0032 20.7 µM 0.989399027962217 0.146068771808352 no 501 0.161233974969435 204 712864 SGTC_2479 5617353 43.85 µM 0.986744500522945 0.146696951923978 no 502 0.161883954247866 187 2731746 SGTC_1179 1021-1431 9.29 µM 0.98461625969819 0.14720189643477 no 503 0.162406299916487 213 2840958 SGTC_1413 3910-0535 34.4 µM 0.984453277708565 0.147240613367044 no 504 0.162446346638107 182 2876951 SGTC_2829 7992743 58.44 µM 0.983554970094543 0.147454131915151 no 505 0.162667187414276 180 16462845 SGTC_3275 9138069 49.47 µM 0.982183126577193 0.14778060525513 no 506 0.163004819374927 213 17617007 SGTC_2092 5303694 80.6725 µM 0.981192393660025 0.148016682108712 no 507 0.163248937206675 188 1963699 SGTC_2170 morpholine 200 µM 0.981176710023553 0.148020421313397 no 508 0.163252803583356 169 121171 Reacts with secondary amines. SGTC_2639 lactacystin 53 µM 0.977959428083722 0.148788804468724 no 509 0.164047195400816 178 3870 A proteasome inhibitor. SGTC_530 4358-1714 28 µM 0.977207200238302 0.148968842793058 no 510 0.16423329205068 203 1564641 SGTC_3348 9149464 3.537 µM 0.97699392862786 0.149019913723176 no 511 0.16428607906555 161 1951442 SGTC_2787 5284540 71.43 µM 0.976532416157058 0.14913046950551 no 512 0.164400346017513 200 736958 SGTC_2903 5923464 63.88 µM 0.975854684133552 0.149292920166857 no 513 0.164568240635126 196 2876576 SGTC_827 3253-0474 693 µM 0.973743297746066 0.149799771343121 no 514 0.165092006618298 203 5402065 SGTC_2027 5150920 200 µM 0.973599610433713 0.149834306023528 no 515 0.16512768992261 182 786715 SGTC_1753 st043925 64 µM 0.972596423311118 0.150075566056519 no 516 0.165376960490067 179 670181 SGTC_2159 5658611 73.75 µM 0.969364939496214 0.150854477002532 no 517 0.166181569450717 174 793844 SGTC_27 0485-0001 32.618 µM 0.968531466505973 0.151055811592284 no 518 0.166389505889746 189 2054479 SGTC_1797 st048695 56.8 µM 0.96591400284469 0.151689250798021 no 519 0.167043607429399 211 592262 YIL048W NEO1 SGTC_3299 9121982 43.1275 µM 0.965423387617806 0.151808178300827 no 520 0.167166395960973 174 17594604 YPL160W CDC60 SGTC_3211 9128781 49.47 µM 0.964595949839959 0.152008893540624 no 521 0.167373614409964 183 17194361 SGTC_2568 diosmetin 100 µM 0.962472420848122 0.152524813679551 no 522 0.167906175169076 221 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1151 3909-8316 15.3 µM 0.957896340588518 0.15364053664286 no 523 0.169057515961147 200 800431 SGTC_2857 9024691 58.44 µM 0.956959118226565 0.153869711778733 no 524 0.169293944996734 188 16478292 SGTC_2465 5809242 33.21 µM 0.956846482875838 0.15389726925939 no 525 0.169322373310097 218 2731748 SGTC_2373 9071805 200 µM 0.956021162865657 0.154099292544667 no 526 0.169530771336138 198 10149009 SGTC_2731 amoxapine 43.43 µM 0.95551407298239 0.154223505870327 no 527 0.169658896018218 218 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1043 0916-0009 19.3 µM 0.95536888848327 0.154259081478519 no 528 0.16969559072798 209 3101130 SGTC_1973 st070275 50.2 µM 0.953509402322633 0.154715204680578 no 529 0.170166017300244 172 17118334 SGTC_3222 9128301 49.47 µM 0.953321584509677 0.154761325005917 no 530 0.170213579262432 198 4911358 SGTC_2421 5690543 90.72 µM 0.951985215761129 0.15508974439354 no 531 0.170552239899346 208 3397993 SGTC_2809 7964133 12.99 µM 0.95070234532571 0.155405448885984 no 532 0.170877748648292 209 1253665 SGTC_2551 apiole 73.87 µM 0.950090937011139 0.155556060852519 no 533 0.171033023935189 172 10659 A possible DNA adduct former. SGTC_525 k781-2675 26.7 µM 0.948988508600199 0.155827872070212 no 534 0.171313228322355 197 3651118 YDL195W SEC31 SGTC_2957 9076800 11.52 µM 0.948882853316791 0.155853938532148 no 535 0.171340098143192 176 16459615 SGTC_13 0199-0087 65 µM 0.947522504848584 0.156189810050649 no 536 0.171686297045219 206 4589825 SGTC_993 3909-8757 62.7 µM 0.94635124231727 0.156479377827372 no 537 0.171984732677462 181 4288324 YLR208W SEC13 SGTC_1581 himbacine 57.9 µM 0.94517683649152 0.156770077410277 no 538 0.172284301526206 194 5281825 An alkaloid muscarinic receptor antagonist. SGTC_478 N-arachidonylglycine 10 µM 0.943962327911507 0.157071077171854 no 539 0.172594449781309 142 5283389 SGTC_2923 7992654 58.14 µM 0.942863856211484 0.157343645893445 no 540 0.172875272186417 196 2985126 SGTC_2069 5228469 200 µM 0.941624599485184 0.157651521274481 no 541 0.173192435374957 204 2835210 SGTC_2139 5578692 56.4705 µM 0.939464117487575 0.158189207530012 no 542 0.173746253435392 205 650991 YMR113W FOL3 SGTC_1255 0566-0045 221 µM 0.937123303114043 0.158773130487772 no 543 0.17434756792012 199 2788469 SGTC_3203 9113543 49.47 µM 0.937113174715296 0.158775660112463 no 544 0.174350172599022 202 17018012 SGTC_2569 tetrandrine 100 µM 0.936121239870777 0.159023529425952 no 545 0.174605384195061 182 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2982 9019404 25.97 µM 0.93538988746599 0.159206445472641 no 546 0.174793703255821 177 22333232 SGTC_1980 st071811 45.7 µM 0.93396698444306 0.159562717589073 no 547 0.175160461909692 205 4974850 SGTC_2937 9044753 11.33 µM 0.931361218717151 0.160216511331711 no 548 0.175833372267235 184 6465530 YGL099W LSG1 SGTC_2270 7924575 90.91 µM 0.93097238849574 0.160314219829016 no 549 0.175933923608701 197 1262135 SGTC_417 st075190 100 µM 0.929890226416176 0.160586359502082 no 550 0.176213961941249 211 222757 SGTC_1091 telmisartan 47.6 µM 0.925504758567795 0.161692294411829 no 551 0.177351704797838 207 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1951 sophoraflavanone G 9.2 µM 0.924232626967666 0.162014029424494 no 552 0.177682605919741 192 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2974 9094440 9.66 µM 0.921974030782449 0.162586278016046 no 553 0.178271060826513 186 25236134 SGTC_3123 9126162 49.47 µM 0.920889687896179 0.162861478905112 no 554 0.178554011496494 196 25239884 SGTC_1831 st055328 12 µM 0.918594605059364 0.163444958060747 no 555 0.179153827436377 194 1103068 SGTC_2151 5563267 85.4165 µM 0.917229497964427 0.163792652542105 no 556 0.179511196253537 229 5310824 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.915828038114113 0.164150105159476 no 557 0.179878547580722 227 279621 SGTC_1539 benzyladenosine 56 µM 0.914435798488701 0.164505706682047 no 558 0.180243949249343 201 92208 A nucleotide analog. SGTC_2256 7954252 200 µM 0.913167630749063 0.164830052344925 no 559 0.180577192625362 205 2972920 SGTC_2044 5102272 200 µM 0.912183678771685 0.165081992357432 no 560 0.180836017099791 202 592666 SGTC_119 0121-0043 24.815 µM 0.912154939701625 0.165089354715413 no 561 0.18084358028606 219 1092378 SGTC_2835 9006588 71.43 µM 0.907724995020136 0.166226756748431 no 562 0.182011767375362 171 2345538 SGTC_3165 9101544 49.47 µM 0.906726666144755 0.166483777986484 no 563 0.182275679150468 209 5002184 SGTC_3200 9114385 49.47 µM 0.904667352837403 0.16701476118798 no 564 0.182820820849343 192 17018030 YLR208W SEC13 SGTC_3061 glucosamine 200 µM 0.902109559216805 0.167675793853673 no 565 0.183499335698512 187 91431 and experimental redox chemotherapeutic SGTC_1792 st045773 43.6 µM 0.89957417731516 0.168332695018413 no 566 0.18417345219317 149 2919270 SGTC_2617 dihydrotanshinone i 20.83 µM 0.898943162999547 0.168496443671806 no 567 0.184341467810463 216 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_288 1315-0019 35.1 µM 0.897283548011062 0.168927603634194 no 568 0.1847838165457 231 6811474 SGTC_2423 st077119 87.2 µM 0.897279916438973 0.168928547875554 no 569 0.184784785216797 204 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_213 1246-0773 967 nM 0.895897873610369 0.169288137581501 no 570 0.185153654974655 190 6251622 SGTC_427 1354-0053 47.3 µM 0.894268964272178 0.169712589131899 no 571 0.185589000589952 193 6813657 SGTC_2796 7949634 45.45 µM 0.894159136603202 0.169741231916761 no 572 0.185618376195138 215 2971588 SGTC_572 0960-0087 17.7 µM 0.892504573116075 0.170173113118334 no 573 0.186061271336727 251 6796365 SGTC_1881 5652484 16 µM 0.892334717043187 0.170217489491463 no 574 0.186106775622006 200 2255129 SGTC_440 fluspirilene 35.1 µM 0.891791088276453 0.170359567059112 no 575 0.186252459630814 211 3396 An atypical antipsychotic. SGTC_480 am 92016 50 µM 0.890478514751237 0.170702921620407 no 576 0.186604499997423 250 2129 K+ channel blocker. SGTC_2608 thymoquinone 42.66 µM 0.887744978451381 0.17141940487672 no 577 0.187338972788273 218 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1279 0874-0590 65.2 µM 0.887708003950688 0.171429109366408 no 578 0.18734891968693 214 3523074 SGTC_1963 st076565 50.3 µM 0.88591131932975 0.171901098155317 no 579 0.187832658016129 233 4914280 SGTC_3004 9076122 71.4286 µM 0.878891220370945 0.173753222560913 no 580 0.189730129736123 220 44782551 SGTC_2244 6635614 200 µM 0.877261653984184 0.174184962417099 no 581 0.19017226752132 190 836499 SGTC_1667 st014849 34.6 µM 0.875491878068219 0.17465462122049 no 582 0.190653163763884 223 5348460 SGTC_1991 st073000 8.92 µM 0.874504225899442 0.174917071166671 no 583 0.190921859928495 226 4301969 YIL048W NEO1 SGTC_108 0509-0257 621.132 µM 0.869925997827817 0.176136915500461 no 584 0.192170423436036 208 536624 SGTC_523 1934-0222 13.7 µM 0.869678528748237 0.176203005353916 no 585 0.192238054616135 229 1361595 SGTC_726 3448-4391 34.2 µM 0.867704777151726 0.176730683183423 no 586 0.192777984997287 229 1356692 SGTC_3038 9091290 49.47 µM 0.867333902454417 0.176829947044377 no 587 0.192879543074626 213 25236843 SGTC_560 2332-1943 155 µM 0.866197907145126 0.177134213118792 no 588 0.193190820437476 221 21177716 SGTC_1250 0485-0349 40.2 µM 0.861770317174348 0.178323256898127 no 589 0.194406961032833 208 6842794 YDL195W SEC31 SGTC_1238 0333-0287 48.8 µM 0.861582064251212 0.17837392405444 no 590 0.194458772159778 225 7226 SGTC_1656 st012921 11 µM 0.86132684978115 0.178442627995525 no 591 0.194529025919508 212 6732821 SGTC_586 0957-0265 8.15 µM 0.86109904142562 0.178503968267898 no 592 0.194591748550726 220 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1121 fusaric acid 630.51 nM 0.859000957332002 0.179069528170659 no 593 0.19516999391788 192 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2969 9091408 28.7 µM 0.858580676106776 0.179182954634724 no 594 0.195285951528949 197 4286311 SGTC_2816 7982706 58.44 µM 0.858553490183622 0.179190293190024 no 595 0.195293453697035 250 2981853 SGTC_2728 chlorpromazine 9.18 µM 0.855813101805262 0.179931002135412 no 596 0.19605058350502 267 2726 A thorazine and dopamine antagonist. SGTC_1197 1601-0112 267 µM 0.85547949235003 0.180021305684276 no 597 0.196142876402282 232 7350313 SGTC_909 3448-9333 149 µM 0.855352276969769 0.180055748653457 no 598 0.196178077415132 199 3344074 SGTC_2088 5278280 127.392 µM 0.8552608279663 0.180080510599332 no 599 0.196203384092668 223 791502 SGTC_1555 citronellol 128 µM 0.854498879559227 0.180286908970153 no 600 0.196414314978441 227 8842 A terpine precursor. SGTC_368 fentichlor 4.58 µM 0.854228913567334 0.180360073593975 no 601 0.196489082876851 226 7329 A pesticide. SGTC_3110 9122132 49.47 µM 0.853760341104853 0.180487107618878 no 602 0.196618896377677 195 918317 SGTC_1899 st063254 59.6 µM 0.851826582994632 0.181011959624141 no 603 0.197155174909895 209 3093813 SGTC_1975 st070967 30.8 µM 0.850118643394927 0.181476315459573 no 604 0.197629563715104 245 261391 SGTC_142 0335-0849 62.6745 µM 0.848427231443667 0.18193691192989 no 605 0.198100041200641 219 3889043 YPR107C YTH1 SGTC_2697 mebhydrolin 72.4 µM 0.846630281775157 0.18242704802423 no 606 0.198600614885306 219 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_438 sphingosine 6.67 µM 0.846612968027316 0.182431774531752 no 607 0.198605441658833 200 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_326 k292-0812 17.5 µM 0.842955878529522 0.183431843432359 no 608 0.199626560121121 222 3579357 SGTC_1233 0325-0408 14.2 µM 0.842933482191564 0.18343797845225 no 609 0.19963282325739 222 12874 SGTC_111 0083-0039 52.457 µM 0.84255338300154 0.183542118377271 no 610 0.199739136033095 190 759313 SGTC_3103 9120822 49.47 µM 0.842374129736978 0.183591243134655 no 611 0.199789284531289 245 17141819 SGTC_1006 4099-6547 255 µM 0.84081706526535 0.1840183047683 no 612 0.200225212683399 234 3146833 SGTC_573 3702-0553 84.7 µM 0.840421859653337 0.184126797561705 no 613 0.200335948473075 220 1222756 SGTC_2319 6033012 152.6 µM 0.839529195846184 0.184372000271149 no 614 0.200586206388471 230 847246 SGTC_2650 prasterone 100 µM 0.837512098449116 0.184926817464047 no 615 0.201152389646645 194 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2961 9083290 32.55 µM 0.834574371987643 0.185736713925443 no 616 0.201978698370776 231 17741490 SGTC_2812 7970281 58.44 µM 0.83273704312782 0.18624436042534 no 617 0.202496524016202 223 2233435 SGTC_2884 9058502 51.95 µM 0.831422464295699 0.186608100332219 no 618 0.202867506445065 215 6471554 SGTC_3347 9188721 44.724 µM 0.830487741941287 0.186867002507848 no 619 0.203131537783387 246 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1960 st011366 51.8 µM 0.828935843253366 0.187297342638966 no 620 0.203570355905302 250 3972846 SGTC_2208 7283366 200 µM 0.826667426823217 0.187927473857068 no 621 0.204212794272094 234 898663 SGTC_3012 9080433 71.4286 µM 0.826372584801772 0.188009472453637 no 622 0.204296385074755 251 17688859 SGTC_852 0418-0143 439 µM 0.824957447297045 0.188403344066003 no 623 0.20469787484841 233 5369229 SGTC_2378 9074213 121.43 µM 0.823622975292554 0.188775230141927 no 624 0.205076908600643 243 657714 SGTC_2049 5262831 67.185 µM 0.823081125143031 0.18892636013277 no 625 0.20523093078555 221 763417 SGTC_170 4197-0004 226 µM 0.821580324642065 0.189345344522793 no 626 0.205657895527344 252 218692 SGTC_1886 st057356 49.9 µM 0.820681441810604 0.189596562835323 no 627 0.205913872166248 207 24207747 SGTC_1955 wogonin 32.4 µM 0.819918440022788 0.189809966156203 no 628 0.206131301922096 207 5281703 A flavanone. SGTC_3327 9140648 26.9345 µM 0.81786910904955 0.190383872515696 no 629 0.20671596547966 252 8029710 SGTC_1463 k081-0032 34.1 µM 0.817458824564095 0.190498898836922 no 630 0.206833135385635 220 977755 SGTC_1410 3909-8106 77.9 µM 0.817347571332562 0.190530096864359 no 631 0.206864914091567 240 1039210 SGTC_393 acivicin 6.25 µM 0.813290823115789 0.191669846402498 no 632 0.208025668633792 237 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2682 pyrogallin 40.03 µM 0.812978129072227 0.19175787125916 no 633 0.208115298880975 230 822798 An ATP competetive kinase inhibitor. SGTC_3092 9117248 49.47 µM 0.812356985502696 0.191932799528409 no 634 0.208293410322093 254 17141857 SGTC_3051 9093778 49.47 µM 0.81176685862603 0.192099083234524 no 635 0.208462711075321 265 17217378 SGTC_336 4111-0029 111 µM 0.811385919232558 0.192206469688397 no 636 0.208572041382098 231 3131175 SGTC_2720 fluspirilene 36.88 µM 0.809162177147324 0.19283407305339 no 637 0.209210933786652 234 3396 An atypical antipsychotic. SGTC_1908 st060353 56.5 µM 0.809076535952201 0.192858268446457 no 638 0.209235561954416 260 4227716 SGTC_2831 7999036 19.48 µM 0.808066285337479 0.193143824898065 no 639 0.209526212392516 234 2988270 SGTC_1122 capsaicin 818.572 nM 0.807379676144499 0.193338048426537 no 640 0.20972388625693 231 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3296 9122258 64.045 µM 0.80439770295987 0.194182951467867 no 641 0.210583663683825 217 4730474 SGTC_1221 2958-7315 257 µM 0.803874397672766 0.194331454786383 no 642 0.210734758730318 237 4562705 SGTC_1661 st013063 9.66 µM 0.801331043825151 0.195054190741273 no 643 0.211470011767834 258 721395 SGTC_2367 9070478 135.38 µM 0.80085048143262 0.195190933784971 no 644 0.21160910512299 229 572802 SGTC_1509 1326-1131 80 µM 0.799858513778207 0.195473380330918 no 645 0.211896388266292 218 768313 SGTC_3224 9130643 49.47 µM 0.799642365437367 0.195534957952416 no 646 0.211959017115279 246 17644395 SGTC_1435 4092-0789 56.7 µM 0.7966994224486 0.196374532565822 no 647 0.212812809729745 247 2248285 SGTC_2800 7887935 81.82 µM 0.796227104373661 0.196509480559147 no 648 0.212950023111422 236 2961002 SGTC_3337 9144342 33.5465 µM 0.795261302168723 0.196785598863887 no 649 0.213230759494494 227 17682949 SGTC_2200 6600604 21.907 µM 0.792728905340101 0.197510714086959 no 650 0.213967892800227 262 2904777 SGTC_329 k048-0121 21.3 µM 0.791668994015981 0.197814683310125 no 651 0.214276852976292 229 6832902 SGTC_1840 st055363 71 µM 0.789362169178892 0.198477227904818 no 652 0.214950180093517 251 676033 SGTC_1205 4161-2785 76 µM 0.788385285031213 0.198758202441873 no 653 0.215235687690597 232 3498106 SGTC_333 3486-0131 40.1 µM 0.788326220113046 0.198775198567043 no 654 0.215252957264468 233 6744690 SGTC_3314 9135860 59.4275 µM 0.78725307948521 0.199084150886095 no 655 0.215566865273115 231 25252478 SGTC_1611 st001856 99.4 µM 0.786936170145261 0.199175442951285 no 656 0.215659616249651 258 647478 SGTC_506 n9-isopropylolomoucine 153 µM 0.784613219846548 0.19984538470451 no 657 0.216340188359443 232 6610355 SGTC_1118 chelidonine 707.474 nM 0.78451347864869 0.199874180503218 no 658 0.216369438092635 240 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2223 6903751 107.57 µM 0.783753203059773 0.200093757983031 no 659 0.216592468896077 239 5598863 SGTC_958 1222-0007 33 µM 0.782933543443202 0.200330648703743 no 660 0.216833069229204 258 7312461 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.782297705646519 0.200514528878004 no 661 0.217019817459292 231 6710655 SGTC_2403 6032726 181.2 µM 0.781525473968653 0.200737989533729 no 662 0.217246750090784 240 2881040 SGTC_2293 7624732 200 µM 0.781525095940619 0.200738098960281 no 663 0.217246861213922 234 894453 SGTC_52 0329-0193 875 nM 0.780531738994309 0.201025766430101 no 664 0.217538976581393 256 3739292 SGTC_1502 4534-4282 27.7 µM 0.774388598660916 0.202810252674547 no 665 0.219350511947226 260 3278949 SGTC_1762 st045503 25.4615 µM 0.774057846832985 0.202906598637775 no 666 0.219448291843394 236 4645554 SGTC_2007 4011539 71.82 µM 0.773665995493973 0.203020777883702 no 667 0.219564166940089 228 45595301 SGTC_850 0388-0143 75.9 µM 0.773622969591895 0.203033317284267 no 668 0.219576892351366 240 67273 SGTC_3013 9080133 71.4286 µM 0.7727821804573 0.203278448341647 no 669 0.219825650526589 263 17050193 SGTC_2332 7982454 138.89 µM 0.771343912797297 0.203698182801656 no 670 0.220251555141475 277 2981748 SGTC_2197 6588183 93.1375 µM 0.76891013571728 0.204409615974444 no 671 0.220973329980621 233 884136 SGTC_1710 st031758 61.5 µM 0.768594963741617 0.204501853987428 no 672 0.221066898095092 253 5394341 SGTC_722 3534-0461 190 µM 0.767536756858267 0.204811729235663 no 673 0.221381223886414 237 658262 SGTC_290 2043-6722 48.1 µM 0.766464393435673 0.205126034644075 no 674 0.221700015233281 247 773758 YLR208W SEC13 SGTC_110 0850-0284 111.64 µM 0.765509651003159 0.205406106872048 no 675 0.22198406089102 226 3906265 SGTC_1540 guanosine 70.6 µM 0.764420571165692 0.205725863900002 no 676 0.222308326859233 245 6802 Guanosine is a purine nucleoside SGTC_491 tetrandrine 80.3 µM 0.764348016711686 0.205747176590338 no 677 0.222329939041768 248 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_527 4476-4215 268 µM 0.764283530642242 0.205766120312539 no 678 0.222349148857581 224 4418754 SGTC_2594 a-mangostin 100 µM 0.764164615445799 0.205801056097582 no 679 0.222384575099894 256 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1756 st041558 35.5 µM 0.763904550272929 0.205877472229797 no 680 0.222462062807187 267 3955792 SGTC_1273 0849-0096 14.1 µM 0.763033053912074 0.206133670658018 no 681 0.2227218416948 251 5286025 SGTC_529 4076-0302 30.3 µM 0.762941939336904 0.206160467005268 no 682 0.222749011446619 254 5816522 SGTC_2002 4023503 131 µM 0.762161668384214 0.206390025400718 no 683 0.222981760317282 264 4736863 YCR052W RSC6 SGTC_2164 5685496 200 µM 0.761498217762304 0.206585333947062 no 684 0.22317977149028 254 759046 SGTC_2484 5809818 12.04 µM 0.761337107584717 0.206632778548971 no 685 0.223227870976791 237 2870548 SGTC_1057 3448-5381 134 µM 0.761237513672979 0.206662110733314 no 686 0.223257607716768 237 5497911 SGTC_2121 5257820 149.641 µM 0.76107378077503 0.206710338352291 no 687 0.223306499968651 231 791256 SGTC_195 4234-0266 16.654 µM 0.761070169770609 0.206711402050814 no 688 0.223307578318718 264 2303354 SGTC_207 4185-0010 4.486 µM 0.7601394975473 0.206985659490237 no 689 0.223585602680147 250 3761753 SGTC_1268 0828-0275 2.46 µM 0.758336611955225 0.207517559439005 no 690 0.224124747363724 262 745337 SGTC_2929 9013348 24.6 µM 0.755692591958023 0.208299076118269 no 691 0.22491676333141 241 2995952 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.754349967499455 0.208696591467611 no 692 0.22531955295376 263 364106 SGTC_45 0kpi-0036 14.9 µM 0.75348250328978 0.208953662115947 no 693 0.225580010756487 252 2795021 SGTC_1868 st057644 42.7 µM 0.753137992277442 0.209055808739594 no 694 0.225683498103695 248 688665 SGTC_697 0508-1955 564 µM 0.751319992387131 0.209595327830502 no 695 0.226230050070304 243 6243113 SGTC_2774 tamoxifen 10.92 µM 0.750434592547976 0.209858379949465 no 696 0.226496501623251 266 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2817 7995342 71.43 µM 0.747493392749493 0.210733601714565 no 697 0.227382894827437 256 18879975 SGTC_477 mead ethanolamide 10 µM 0.744411585509718 0.211652957609371 no 698 0.228313756049905 219 16061185 SGTC_1187 1391-0724 117 µM 0.741629356784133 0.212484956983487 no 699 0.229155965888267 249 6997986 SGTC_105 0111-0055 734.78 µM 0.740738767622735 0.212751682444918 no 700 0.229425924259821 240 5179370 SGTC_1177 0983-0204 23.6 µM 0.739591555115646 0.213095552778667 no 701 0.229773933691178 253 766818 SGTC_3039 9090270 49.47 µM 0.738914336684005 0.213298697193964 no 702 0.22997950806121 238 17173750 SGTC_623 k072-0108 16.9 µM 0.738498064774906 0.213423621802403 no 703 0.230105921363069 259 5382803 SGTC_1321 1326-2144 215 µM 0.737688199649888 0.213666787225797 no 704 0.230351972266717 262 3513030 SGTC_2328 6201408 200 µM 0.736989221650865 0.213876788023759 no 705 0.230564451984312 280 2890418 SGTC_465 cgp-37157 41 µM 0.736063048114296 0.21415523243578 no 706 0.230846164667709 233 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1328 1441-0025 69.2 µM 0.736018983871023 0.214168485145185 no 707 0.230859572404618 248 4562601 SGTC_2756 carbadox 75.1 µM 0.735662522577019 0.214275711563029 no 708 0.230968051373505 263 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_959 1222-0044 107 µM 0.73562686190681 0.214286440296873 no 709 0.230978905261071 258 6083612 SGTC_1407 3909-7909 12.3 µM 0.735101155106842 0.214444638702738 no 710 0.231138945454373 242 4411780 SGTC_1274 0865-0114 173 µM 0.733333033199143 0.21497720913145 no 711 0.231677666140599 247 870624 SGTC_2895 9054447 58.44 µM 0.733021557673227 0.215071107202636 no 712 0.231772640576376 273 2697450 SGTC_3018 9082602 49.47 µM 0.732543708344057 0.215215206951204 no 713 0.231918387503328 264 17332089 SGTC_3188 9110789 49.47 µM 0.731820257474262 0.215433476652811 no 714 0.232139141482739 263 849217 SGTC_3256 9138902 49.47 µM 0.731215812392767 0.215615939983059 no 715 0.232323671650029 284 17228773 SGTC_1287 0971-0001 34.6 µM 0.730904223681664 0.215710033998301 no 716 0.232418827985395 250 4665869 SGTC_283 0987-0079 11.7 µM 0.73017688616894 0.215929769059945 no 717 0.232641034529727 248 411556 SGTC_80 0159-0065 512.242 µM 0.729736008188033 0.216063025285943 no 718 0.232775783208606 245 1548079 SGTC_1210 3013-0140 750 nM 0.729027890247941 0.216277154972725 no 719 0.232992301083048 254 905973 SGTC_1743 st037606 46.3785 µM 0.728250585843732 0.216512347529151 no 720 0.233230102496386 227 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1078 idebenone 36.1 µM 0.728212152910344 0.216523980196068 no 721 0.233241863811145 278 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2824 7998404 51.95 µM 0.727510173879672 0.216736514925447 no 722 0.233456742590741 276 837851 SGTC_2273 7815444 169.05 µM 0.727282631447713 0.216805432707703 no 723 0.233526417859981 268 2824616 SGTC_468 gf-109203x 121 µM 0.727272433732859 0.216808521676129 no 724 0.233529540749882 229 2396 A protein kinase C inhibitor. SGTC_32 0928-0142 34.1 µM 0.726666473083959 0.216992117621531 no 725 0.233715148247213 271 2244242 SGTC_2031 5180455 200 µM 0.726253294191734 0.217117355422198 no 726 0.233841753010592 271 29949 SGTC_3247 9135149 49.47 µM 0.72461703895857 0.217613727344174 no 727 0.234343501430737 270 8934436 YOR116C RPO31 SGTC_2448 5185112 27.17 µM 0.723945493775454 0.217817635664116 no 728 0.234549599286093 248 5718189 SGTC_1193 1488-0126 41.5 µM 0.721982610929112 0.218414277847639 no 729 0.235152584328569 253 1384710 SGTC_328 k915-0120 63.5 µM 0.721878445573245 0.218445966457733 no 730 0.235184607162847 238 6624543 SGTC_768 0384-0033 77.3 µM 0.721632953774953 0.218520659091206 no 731 0.23526008653173 249 3965305 YMR134W ERG29 SGTC_1904 st060225 78 µM 0.721158407367134 0.218665084907347 no 732 0.235406029368375 244 66595 SGTC_701 4424-0219 185 µM 0.719593218059707 0.219141831703209 no 733 0.235887744449268 257 2911779 SGTC_2364 9055074 200 µM 0.719589469535144 0.219142974197033 no 734 0.235888898776774 257 6470630 SGTC_1717 st033143 58.0435 µM 0.719154519686896 0.219275563609505 no 735 0.236022859167242 263 674616 SGTC_1929 genistein trimethyl ether 50.5 µM 0.716308383840152 0.220144312297821 no 736 0.236900475566041 253 136420 SGTC_2138 5575593 77.673 µM 0.716227916867834 0.220168902532811 no 737 0.236925313901729 264 762213 SGTC_2145 5634607 200 µM 0.716173082913118 0.220185660370353 no 738 0.236942240724372 266 308662 SGTC_204 PMA1.184 62.41 µM 0.716123873097672 0.220200700034116 no 739 0.236957431984183 276 2252213 YGL008C PMA1 SGTC_279 1273-0055 2.93 µM 0.715733236261915 0.220320108631285 no 740 0.237078042072948 280 2847562 SGTC_689 0833-0039 98 µM 0.715663029479075 0.220341573146996 no 741 0.237099722166377 299 5374726 SGTC_1824 st053723 68.6 µM 0.714110079449795 0.220816667331726 no 742 0.237579556866823 268 675225 SGTC_3236 9132701 49.47 µM 0.713836681413631 0.22090036870599 no 743 0.237664087265095 268 24282524 SGTC_391 gliotoxin 8.33 µM 0.712764348589804 0.221228840897782 no 744 0.237995795043017 282 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1243 0416-0003 5.65 µM 0.711820707023104 0.221518123928698 no 745 0.238287904190064 276 2141977 SGTC_153 4077-0274 519.67 µM 0.709908418010821 0.22210501839569 no 746 0.238880464950815 274 3121976 SGTC_2344 7990960 76.95 µM 0.70930535502698 0.222290286436023 no 747 0.239067503012518 274 140813 SGTC_528 3492-0019 172 µM 0.708893046397405 0.222417003227275 no 748 0.239195425280092 273 2869262 SGTC_402 epigallocatechin gallate 10 µM 0.708812680833829 0.222441707158922 no 749 0.239220363736503 275 65064 An antioxidant. SGTC_2377 9073351 62.6 µM 0.708164872217535 0.222640897098859 no 750 0.239421438861083 271 7337946 YHR072W ERG7 SGTC_1690 st023502 41.2 µM 0.707955234274775 0.222705378908334 no 751 0.239486528729568 270 24207482 SGTC_343 4130-2827 29.8 µM 0.70772992746787 0.22277469211523 no 752 0.239556494348669 253 1118244 SGTC_837 0091-0265 12.5 µM 0.706847224865501 0.223046364437387 no 753 0.239830711749588 279 759367 SGTC_194 1486-1323 56.904 µM 0.70482005269473 0.22367098762246 no 754 0.240461113868411 265 5178754 SGTC_1475 4092-1048 11.7 µM 0.704593654973444 0.223740808193659 no 755 0.240531574129056 277 2881759 SGTC_643 k048-0106 28.4 µM 0.703366561154535 0.224119456800357 no 756 0.240913669921484 275 6763920 SGTC_1045 1348-1485 165 µM 0.701626496719549 0.224657017997201 no 757 0.241456061461634 258 6810614 SGTC_1510 1123-0200 71.5 µM 0.700901324015359 0.224881262611099 no 758 0.2416822990581 280 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_644 1498-1197 63.3 µM 0.700791218492464 0.224915321551938 no 759 0.241716659567542 267 6741615 SGTC_76 0433-0009 400.328 µM 0.700326157521957 0.225059211112631 no 760 0.241861819880877 277 2841569 SGTC_46 0329-0187a 2.197 µM 0.697826694992231 0.225833436096509 no 761 0.242642791186389 272 46494817 SGTC_1529 apigenin 74 µM 0.696268354256242 0.22631690373307 no 762 0.243130393768133 281 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3155 9099265 49.47 µM 0.695924956506232 0.226423519772854 no 763 0.243237913629112 270 25236499 SGTC_2442 5158906 48.48 µM 0.694455764627133 0.226879985638905 no 764 0.243698216362053 260 1893835 SGTC_2653 dihydrofissinolide 100 µM 0.694455304277118 0.226880128747179 no 765 0.243698360664919 269 6857746 SGTC_2691 st077356 60.2 µM 0.69417100588575 0.226968517858982 no 766 0.243787486606804 287 2839272 SGTC_292 k038-0015 474 µM 0.693572091952816 0.227154785295009 no 767 0.243975300303985 281 46368540 SGTC_1011 4112-3381 17.4 µM 0.693168973825324 0.227280207036592 no 768 0.244101758242961 280 2877139 SGTC_381 3461-2219 42.7 µM 0.69283362846134 0.227384572432622 no 769 0.244206982831116 286 2883159 SGTC_743 1275-0778 158 µM 0.690767696105235 0.228028122211944 no 770 0.244855769661106 279 2849257 YMR203W TOM40 SGTC_2171 5739187 198.077 µM 0.690256830770343 0.228187417531192 no 771 0.245016345105571 265 2262761 SGTC_8 0354-0001 70 µM 0.690225963023099 0.228197044552345 no 772 0.245026049285703 259 4993152 SGTC_1992 st073643 23.3 µM 0.689839767861324 0.228317510249203 no 773 0.245147478516194 280 3161292 SGTC_50 0929-0078 56.389 µM 0.689662462481003 0.2283728290124 no 774 0.245203238513835 245 1377751 SGTC_1842 st055362 61.2 µM 0.687048248140166 0.229189329963996 no 775 0.246026162354289 255 676032 SGTC_1766 st045414 44.774 µM 0.685635002958941 0.229631411491898 no 776 0.246471651505705 293 253960 SGTC_2754 granisetron 64.02 µM 0.685480609242108 0.229679736786374 no 777 0.246520346325572 280 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2165 5727197 32.143 µM 0.684381477687575 0.230023929967631 no 778 0.246867154502902 275 1361712 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.68415659030586 0.230094389033026 no 779 0.2469381452227 296 7104 SGTC_1608 st001473 40.5 µM 0.683651772696286 0.230252596508885 no 780 0.247097541943067 295 7292267 SGTC_2109 5483026 200 µM 0.682387269995313 0.230649152671801 no 781 0.247497051545119 306 759335 SGTC_1622 st003707 19.4 µM 0.682206847849726 0.230705765305666 no 782 0.247554082613924 250 10140899 SGTC_2411 st077133 39.94 µM 0.680471371854971 0.231250717054165 no 783 0.2481030213874 286 1403142 YNL221C POP1 SGTC_3250 9135583 49.47 µM 0.680159263192642 0.231348797511751 no 784 0.248201811586739 268 7699353 SGTC_3015 9080845 49.47 µM 0.67775240570461 0.232105933685922 no 785 0.248964346315115 270 5296973 SGTC_2898 9056270 58.44 µM 0.676200512021877 0.232594850444572 no 786 0.24945667376542 233 19154699 SGTC_1946 st076057 65.1 µM 0.676160149877475 0.23260757398168 no 787 0.249469485273973 275 953009 SGTC_513 4245-1575 41.7 µM 0.676016495272717 0.232652861996564 no 788 0.249515086089315 271 719745 SGTC_2792 7535235 81.82 µM 0.67561729826654 0.23277873708609 no 789 0.249641827930248 271 1281891 SGTC_819 1013-0258 27.7 µM 0.675520113254106 0.232809387261746 no 790 0.249672688565602 275 5753198 SGTC_3238 9133470 49.47 µM 0.675328748542471 0.232869746352798 no 791 0.24973346143591 253 3534688 SGTC_2258 7960471 200 µM 0.675066095155458 0.232952605036508 no 792 0.249816886678194 290 2974708 SGTC_1119 parthenolide 318.541 nM 0.673901673677962 0.233320139658185 no 793 0.250186913997047 302 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_392 N-ethylmaleimide 8.33 µM 0.671876869927935 0.233960008403773 no 794 0.25083104327527 269 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.671821058248327 0.233977659499034 no 795 0.25084881047616 299 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3070 9117005 49.47 µM 0.671298618338294 0.234142922987936 no 796 0.251015157335899 281 8779016 SGTC_1005 4092-0690 4.4 µM 0.66865861346045 0.234979023863414 no 797 0.251856636857439 292 1529343 SGTC_2840 9008771 71.43 µM 0.667589811243845 0.235317986648713 no 798 0.252197731620282 230 2992978 SGTC_355 1311-2252 105 µM 0.66617482636915 0.235767153651659 no 799 0.25264968070437 295 5338538 SGTC_2238 6671620 73.2395 µM 0.664254582170148 0.236377463454419 no 800 0.253263692244929 255 729941 SGTC_1421 4029-0249 71.4 µM 0.664001328416586 0.236458019775442 no 801 0.253344730429608 299 2894095 SGTC_692 k241-0027 77.8 µM 0.663143669782542 0.236730940664079 no 802 0.253619272188574 277 3600480 SGTC_2689 tacrolimus 100 µM 0.661046795047988 0.237398929232587 no 803 0.254291152091776 271 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2534 helenine 20.12 µM 0.660851420220753 0.237461221257855 no 804 0.254353801517127 273 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_732 3970-1727 52.7 µM 0.660241592906282 0.237655712288385 no 805 0.254549402433095 289 1275699 SGTC_1363 1636-0063 10.4 µM 0.659551912236166 0.237875776070076 no 806 0.254770711072828 283 6072185 SGTC_2379 9035213 200 µM 0.658338204800384 0.238263317871515 no 807 0.25516041686977 272 646551 SGTC_2153 5569715 200 µM 0.658256494732138 0.23828942065427 no 808 0.255186664113818 282 2054701 SGTC_2626 ethyl orsellinate 100 µM 0.658058034892654 0.238352826389965 no 809 0.255250420077839 300 75653 A natural product. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.65769107111014 0.238470091616239 no 810 0.255368330494795 278 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1055 3448-0672 86 µM 0.656798432853842 0.238755470732693 no 811 0.255655266016252 273 748378 SGTC_1135 dihydrocapsaicin 536.708 nM 0.656444884833144 0.238868552724579 no 812 0.255768959351503 305 107982 A Capsaicinoid. SGTC_1489 4065-0444 182 µM 0.656368298390868 0.23889305268335 no 813 0.255793591359301 276 2877968 SGTC_3160 9100216 49.47 µM 0.656091649624622 0.238981563911115 no 814 0.255882578447723 276 17191039 SGTC_358 0075-0058 9.45 µM 0.654233332948656 0.239576579719614 no 815 0.256480744732622 332 1069125 SGTC_784 4579-0127 173 µM 0.653564020006005 0.239791085460386 no 816 0.256696365561674 290 1948547 SGTC_688 0527-0193 473 µM 0.65089021205439 0.240649049201594 no 817 0.257558680123177 311 4007154 SGTC_2133 5320837 200 µM 0.648830915481605 0.241310967694645 no 818 0.258223836204916 286 2841355 SGTC_550 4123-0385 25.7 µM 0.647536303405913 0.241727600021229 no 819 0.258642453365491 286 5731123 SGTC_109 0132-0036 33.701 µM 0.646353838262794 0.242108482102835 no 820 0.259025114225244 259 67274 A color developer. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.645914375207546 0.242250119788864 no 821 0.25916740468688 301 4620898 SGTC_1860 st056228 74.6 µM 0.644982812037968 0.242550508380018 no 822 0.259469162123558 316 688679 SGTC_2166 5933061 31.504 µM 0.642431939890053 0.243374085118234 no 823 0.260296383473694 297 2877375 SGTC_2956 9076196 2.52 µM 0.642325051941694 0.243408628007097 no 824 0.260331075763785 313 16423868 SGTC_3266 9136860 49.47 µM 0.640974812359007 0.243845211810378 no 825 0.260769523855878 287 4871271 YPR165W RHO1 SGTC_275 trichlorophene 5.69 µM 0.640840233362899 0.243888749465491 no 826 0.260813244989767 282 62616 SGTC_610 4215-0184 155 µM 0.640511045685331 0.243995262657828 no 827 0.260920205196249 272 5605015 SGTC_444 curcumin 90.4 µM 0.640476643246113 0.244006395487456 no 828 0.260931384595742 283 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1713 st033146 12.748 µM 0.63921533945937 0.244414749861325 no 829 0.261341427253527 304 674619 SGTC_2135 5326629 150.42 µM 0.638716358614036 0.244576399385912 no 830 0.261503734397632 293 5020077 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.636302905449017 0.245359072342109 no 831 0.262289505794746 313 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2711 st079103 59.1 µM 0.636295895964381 0.245361347448077 no 832 0.262291789700856 292 54693780 SGTC_620 0109-0052 432 µM 0.636102514849918 0.245424118663178 no 833 0.262354803244357 299 493037 SGTC_3265 9137266 49.47 µM 0.635470885146139 0.245629204813279 no 834 0.262560674788803 258 17224265 SGTC_1901 st060216 58.6 µM 0.634088263639149 0.24607845429444 no 835 0.263011610816537 284 688792 SGTC_102 gallobenzophenone 83.616 µM 0.633667820351826 0.246215154531667 no 836 0.263148815023391 281 70837 SGTC_587 k089-0003 57 µM 0.632669961497453 0.246539754902724 no 837 0.263474594876992 295 9659696 SGTC_3118 9124250 49.47 µM 0.628834013009735 0.2477897086984 no 838 0.264728864953688 290 1504786 SGTC_2985 9022375 71.43 µM 0.62851247807133 0.247894635166181 no 839 0.264834137498303 301 4939335 SGTC_2194 5927483 104.545 µM 0.627046396315507 0.248373361924316 no 840 0.265314411390782 258 760979 SGTC_1728 st035614 33.7865 µM 0.626947340854867 0.248405724745485 no 841 0.265346876918205 306 15945546 SGTC_77 0828-0286 12.516 µM 0.626832740348497 0.248443169157224 no 842 0.265384439865784 287 745345 SGTC_1683 st010134 710 nM 0.626720086764255 0.248479980365924 no 843 0.265421367294999 306 3818134 SGTC_869 0564-0080 44.1 µM 0.624033843435313 0.249358609993758 no 844 0.266302679619114 278 6843321 SGTC_1561 5-methoxyflavone 52.9 µM 0.62311669137376 0.249658974342488 no 845 0.266603920939338 287 94525 SGTC_1391 3442-0225 151 µM 0.623115507836801 0.249659362071145 no 846 0.266604309786858 298 5227075 SGTC_453 enantio-paf c16 10 µM 0.622343539822732 0.24991232818689 no 847 0.266857998642488 321 13871343 A lipid and platelet activating factor SGTC_1994 st072947 40.9 µM 0.622187728322379 0.249963402536023 no 848 0.266909217160781 313 5286565 YDL195W SEC31 SGTC_951 1171-0579 82.7 µM 0.621966411398302 0.250035958806262 no 849 0.266981977225633 299 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_627 1391-0720 175 µM 0.621347082630012 0.25023905816697 no 850 0.2671856407336 328 997839 SGTC_690 glyoxal 20.3 µM 0.620621790874051 0.250477017630632 no 851 0.267424249348227 298 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2592 piperlongumine 83.33 µM 0.619171162133983 0.250953310920586 no 852 0.267901803684786 303 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2438 5259590 200 µM 0.618674456416207 0.251116507258656 no 853 0.268065420380681 291 1201127 SGTC_2006 4011487 200 µM 0.616748044501909 0.251749974848806 no 854 0.268700463065322 299 45595294 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.615852581791378 0.252044719452888 no 855 0.268995909924698 314 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_912 3474-0017 2.18 µM 0.614005834766269 0.252653156982915 no 856 0.269605735770889 313 3360550 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.613956969983453 0.252669266691584 no 857 0.269621881116888 325 6708760 SGTC_874 0599-0792 117 µM 0.613828181187187 0.252711728286927 no 858 0.269664436367394 304 765305 SGTC_104 0074-0074 590.992 µM 0.612564845670121 0.253128448454504 no 859 0.270082054384987 290 3943124 SGTC_2336 9001819 198.65 µM 0.610950419696618 0.253661503904096 no 860 0.270616202108437 304 2989602 SGTC_1920 st075728 45.7 µM 0.610743416560789 0.253729895366262 no 861 0.270684729149613 312 3400306 SGTC_2643 anethole 100 µM 0.608777652397711 0.254379843547442 no 862 0.271335914127922 326 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3097 9117246 49.47 µM 0.608747589913331 0.254389789992556 no 863 0.271345878774938 279 16423892 SGTC_177 1327-0068 8.361 µM 0.608129880983804 0.254594209698626 no 864 0.271550667731377 295 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2991 9074669 71.4286 µM 0.607829474080878 0.254693655070745 no 865 0.271650289402155 307 17333109 SGTC_1721 st082152 9.2685 µM 0.607560160951772 0.254782824586061 no 866 0.271739615145048 310 5296051 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.606565370706026 0.255112341037589 no 867 0.272069693724798 291 688669 SGTC_1731 st035964 63 µM 0.601218989956561 0.256887098450416 no 868 0.273847068915384 324 6739575 SGTC_2856 9022925 19.48 µM 0.601034129952279 0.256948578350261 no 869 0.273908627154263 286 4944862 SGTC_1572 epiandrosterone 68.9 µM 0.600754476253666 0.257041598853936 no 870 0.274001764620186 297 441302 A steroid. SGTC_2376 9072922 81.32 µM 0.600721403662737 0.257052600864458 no 871 0.27401278033972 299 17087968 SGTC_1080 nisoldipine 24.4 µM 0.599600368473697 0.257425672032469 no 872 0.274386300769786 313 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2359 9039622 200 µM 0.598602801960974 0.257757890247136 no 873 0.274718893567315 314 6463596 SGTC_543 3844-1095 191 µM 0.597699684026929 0.258058846202536 no 874 0.275020168166224 314 4230703 SGTC_3344 9148862 3.898 µM 0.597264582361006 0.258203904952948 no 875 0.275165373484727 319 4905352 SGTC_1799 st045822 46.1415 µM 0.596476593514866 0.258466720482209 no 876 0.275428442953173 315 3674992 SGTC_492 tmb-8 126 µM 0.596173159702994 0.258567960781548 no 877 0.275529777084639 313 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_160 3453-0671 289.699 µM 0.595838994336965 0.258679478379823 no 878 0.275641395474514 306 5322268 SGTC_2117 5521686 200 µM 0.59454230458861 0.25911244505996 no 879 0.276074728010837 300 803312 SGTC_2587 piperic acid 92.2 µM 0.594535220445869 0.259114811494649 no 880 0.276077096333971 296 5370536 SGTC_760 0568-0725 82.9 µM 0.594400068291716 0.259159960769284 no 881 0.276122281406918 304 3916171 SGTC_237 nikkomycin 200 µM 0.594095728866386 0.259261644064751 no 882 0.276224043716028 311 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2606 farnesol 9.78 µM 0.59270651149227 0.259726059262047 no 883 0.276688791471632 316 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2072 5231554 129 µM 0.59251375962331 0.259790530089591 no 884 0.276753304796405 300 789545 SGTC_264 promethazine 12.5 mM 0.592498154286392 0.259795750057806 no 885 0.276758528166357 316 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2821 7996764 71.43 µM 0.592035567114478 0.25995050953934 no 886 0.276913385840364 253 2987135 SGTC_334 1502-1024 68.5 µM 0.591527482141839 0.260120545178709 no 887 0.277083523432623 314 3296216 SGTC_2060 5238662 140 µM 0.591209706106608 0.260226921194339 no 888 0.2771899600749 312 790130 SGTC_2187 6125751 200 µM 0.591194792740558 0.260231914017205 no 889 0.277194955683658 308 874498 SGTC_136 0097-0015 404.482 µM 0.591182479742531 0.260236036304068 no 890 0.277199080266641 302 4861337 SGTC_2294 7971431 200 µM 0.591171647105207 0.260239663006602 no 891 0.277202708986239 350 5741572 SGTC_1605 st000082 49.1 µM 0.590379020711725 0.260505100265494 no 892 0.277468286215907 309 1114022 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.589244541233499 0.260885260794889 no 893 0.27784862092505 281 6708561 SGTC_2652 actinonin 100 µM 0.588170464314218 0.261245443396255 no 894 0.278208940038632 306 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3022 9087993 49.47 µM 0.587642988706757 0.261422421376506 no 895 0.278385974944632 315 17173644 SGTC_781 4335-2806 94.4 µM 0.587320061177339 0.261530800008545 no 896 0.278494385138483 332 845254 SGTC_1794 st048918 76.9 µM 0.586869880497737 0.26168192491611 no 897 0.278645549876334 307 672303 SGTC_593 1203-0218 61.7 µM 0.585869334993621 0.262017966782298 no 898 0.27898166287714 328 3666956 SGTC_418 lividomycin a 100 µM 0.583956706504249 0.26266095466214 no 899 0.279624719958006 306 72394 An antibiotic. SGTC_3350 9150499 3.57 µM 0.58345005631864 0.262831415590829 no 900 0.279795184521648 311 4910996 YPR165W RHO1 SGTC_2939 9044578 71.43 µM 0.582316473341061 0.263213010952758 no 901 0.28017676571445 325 2653634 SGTC_2858 9025781 8.96 µM 0.580325563372504 0.263883890591087 no 902 0.280847545824281 287 4894980 YPL153C RAD53 SGTC_273 hydroxyurea 18.1 mM 0.578901039381855 0.264364448812824 no 903 0.281327974421482 322 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2232 chlorophetanol 41.5365 µM 0.57713927615375 0.26495938908616 no 904 0.281922686953879 305 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_865 0488-0499 301 µM 0.574572722742529 0.265827319594065 no 905 0.282790152166243 294 9634651 SGTC_1591 genipin 88.4 µM 0.574114994730688 0.265982260593012 no 906 0.28294499353632 317 442424 A DNA cross-linking agent. SGTC_1208 2323-2347 50.3 µM 0.573675063829735 0.266131220371268 no 907 0.283093852808907 322 5412760 SGTC_2514 salinomycin 42.74 µM 0.573143578799697 0.266311236532018 no 908 0.28327374133614 329 23682228 A polyether potassium ionophore. SGTC_1790 st045711 43.5 µM 0.569791051696788 0.267448169731477 no 909 0.284409712715497 281 585119 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.568622106433968 0.26784516568172 no 910 0.284806309655279 304 1241132 A phosphatase inhibitor. SGTC_3205 9113483 49.47 µM 0.565598263878691 0.268873495127088 no 911 0.285833454152274 347 17018033 SGTC_676 falcarinol 140 µM 0.565090721995569 0.269046290896295 no 912 0.286006029423715 340 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2041 5107442 45.335 µM 0.558896962317162 0.271159474470095 no 913 0.28811602133843 323 793005 SGTC_324 1315-0088 19.6 µM 0.558874352531933 0.271167203598509 no 914 0.288123737119067 337 6787421 SGTC_141 0443-0274 32.331 µM 0.558408132634773 0.27132660480253 no 915 0.288282860335266 284 1627241 SGTC_2513 baicalein 25.65 µM 0.558106249812292 0.2714298438438 no 916 0.288385916574938 317 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2930 9013230 14.89 µM 0.557515169971979 0.27163204024249 no 917 0.288587748675131 313 2995857 SGTC_1081 sertraline 6 µM 0.557186032476272 0.271744663986703 no 918 0.28870016590326 322 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_984 1492-0255 2.91 µM 0.556914078908904 0.271837738157245 no 919 0.288793067462144 327 1585198 SGTC_899 1083-0020 478 µM 0.556779758286433 0.271883714284294 no 920 0.288838957675051 342 767123 SGTC_1893 st059353 36.1 µM 0.555830429272936 0.27220876697714 no 921 0.289163390724467 352 3112488 SGTC_3008 9078912 71.4286 µM 0.555489616186269 0.272325509351316 no 922 0.289279905329132 327 16648731 SGTC_2343 7990716 14.84 µM 0.555128013366042 0.27244940024706 no 923 0.28940355149072 329 6456862 SGTC_3007 9078383 71.4286 µM 0.553933230493146 0.272858950852154 no 924 0.289812270978509 317 6496995 SGTC_96 0929-0093 37.281 µM 0.553882749198804 0.2728762616751 no 925 0.289829545925389 317 6991579 SGTC_1556 plumbagin 1.48 µM 0.55330237185835 0.273075321234403 no 926 0.290028188593801 312 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2349 9023730 187.07 µM 0.551337776083955 0.273749677886985 no 927 0.290701073576961 324 4126287 SGTC_1660 st012960 28.1 µM 0.550203899128819 0.274139260958028 no 928 0.291089764756318 334 24207266 SGTC_996 3970-0799 1.8 µM 0.549478293897237 0.274388711636295 no 929 0.29133862835367 334 6615648 YGL040C HEM2 SGTC_3223 9129970 49.47 µM 0.547694967018416 0.275002264602304 no 930 0.291950684279534 325 17248386 SGTC_2505 galangin 7.89 µM 0.546943650007448 0.275260957154642 no 931 0.292208723068577 351 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1953 st076800 12.1 µM 0.54661016516696 0.275375820618858 no 932 0.292323291967429 315 297591 SGTC_805 3852-0218 479 µM 0.542453224268427 0.276809587841286 no 933 0.293753161236465 307 6615355 SGTC_1007 4101-0031 70 µM 0.542413607578571 0.276823269573205 no 934 0.293766803805112 351 1146276 SGTC_900 1112-0045 141 µM 0.542330418556559 0.276852000206854 no 935 0.293795452078008 311 56211 YIL048W NEO1 SGTC_1516 st013856 110 µM 0.538966565072998 0.278014981646315 no 936 0.294954962567465 326 5281404 A mutagen and neurotoxin. SGTC_979 1426-2828 121 µM 0.537334404629883 0.278580124330172 no 937 0.295518322230457 323 747872 SGTC_2024 5144227 134 µM 0.537198240505161 0.278627297027486 no 938 0.295565343256915 327 3475211 SGTC_1377 2944-0135 198 µM 0.536840697674204 0.278751182674314 no 939 0.295688828501236 309 1894137 SGTC_995 3931-2021 34.6 µM 0.536734386228423 0.278788023885723 no 940 0.295725550059004 324 730143 SGTC_2908 7930301 100 µM 0.536206741348501 0.278970909217635 no 941 0.295907837467151 305 2223178 SGTC_611 3453-1652 23.7 µM 0.53572096806172 0.279139333146902 no 942 0.29607570494738 333 1560575 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.534628389718728 0.279518324827468 no 943 0.296453424160468 335 5106787 A p450 inhibitor. SGTC_1223 0764-0573 147 µM 0.533142446560682 0.280034166850017 no 944 0.29696748907691 314 1609797 SGTC_1966 st070145 16.1 µM 0.533083751838679 0.280054552068744 no 945 0.296987802999371 339 3748532 SGTC_1034 k072-0165 12.7 µM 0.530215415552626 0.281051627210481 no 946 0.297981292039504 347 5835461 SGTC_788 1182-0090 188 µM 0.529775258637618 0.281204783767361 no 947 0.29813388061047 309 5715185 SGTC_2418 pentamidine 31.67 µM 0.528950456919284 0.281491889418245 no 948 0.298419909250231 315 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_284 0988-0104 32.6 µM 0.528610129359447 0.281610395412613 no 949 0.298537966034251 332 4666532 SGTC_3315 9136395 68.55 µM 0.527468939545779 0.282007946419555 no 950 0.29893399020475 367 16876844 SGTC_2050 5263056 171 µM 0.524628633230168 0.282998582691634 no 951 0.299920688923945 324 763468 YGL055W OLE1 SGTC_2983 9022671 12.99 µM 0.524033252600589 0.283206449932462 no 952 0.300127705921116 356 6405161 SGTC_733 4069-0007 56.1 µM 0.521300732479832 0.28416140218636 no 953 0.301078645410059 331 5717425 YNL287W SEC21 SGTC_3343 9148379 18.9835 µM 0.520926404195292 0.28429234104157 no 954 0.301209020416868 320 1955036 SGTC_2919 7978188 46.38 µM 0.520459019046999 0.284455871368543 no 955 0.301371841940951 306 2980291 SGTC_1207 2099-0101 141 µM 0.519758199817881 0.284701160592246 no 956 0.30161605839703 338 5837381 SGTC_182 3448-4371 550.524 µM 0.519253741173314 0.284877785383707 no 957 0.301791903602856 302 3491403 SGTC_1371 2421-0008 32.7 µM 0.517872734533319 0.28536158089354 no 958 0.302273533251249 332 2827552 SGTC_2265 7929201 200 µM 0.516949225709045 0.285685323535277 no 959 0.302595801649872 379 1265108 SGTC_792 4534-1957 155 µM 0.515170746606825 0.286309273959458 no 960 0.303216854545553 324 1717904 SGTC_856 0433-0016 11.3 µM 0.514737288277563 0.28646144375479 no 961 0.303368306479409 330 3911780 SGTC_127 0180-0333 59.125 µM 0.514679771818857 0.286481638355119 no 962 0.303388405481698 301 771601 SGTC_1446 4239-0190 62 µM 0.513623122504365 0.286852758575707 no 963 0.303757755123333 354 1340085 SGTC_1512 0259-0544 12.2 µM 0.513443423729908 0.286915895694389 no 964 0.303820588425885 331 18476 SGTC_619 1652-1634 108 µM 0.51050788004158 0.287948229348643 no 965 0.304847847689848 333 5400454 SGTC_2990 9074105 71.4286 µM 0.510083451611003 0.288097631779077 no 966 0.304996499098026 346 6502001 SGTC_2621 lithochol-11-enic acid 100 µM 0.509822893642344 0.288189368525923 no 967 0.305087772617822 367 6708711 SGTC_3104 9120930 49.47 µM 0.509641320860018 0.288253304467083 no 968 0.305151384776934 351 17014836 SGTC_2810 7959871 45.46 µM 0.509131105734573 0.288432998717182 no 969 0.305330164911615 342 2974535 SGTC_2877 9040724 71.43 µM 0.50895731824043 0.288494217527813 no 970 0.305391070913061 330 6463895 SGTC_493 zm226600 134 µM 0.508196358912782 0.288762347014253 no 971 0.305657822051782 349 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1014 4130-3005 69.3 µM 0.507549524765325 0.288990355887755 no 972 0.305884648212459 338 743608 SGTC_766 1391-0721 126 µM 0.5072884074605 0.289082423663116 no 973 0.305976235658582 361 1020919 YIL115C NUP159 SGTC_1010 4112-3296 15.2 µM 0.507182882349756 0.289119634847132 no 974 0.306013252256627 321 704384 SGTC_1046 2001-0062 216 µM 0.506618784197033 0.28931859024571 no 975 0.306211162872852 325 739778 SGTC_70 0141-0289 43.283 µM 0.506041339468931 0.289522319547957 no 976 0.306413814649398 323 352408 SGTC_2243 6634756 200 µM 0.505964267093536 0.289549516685053 no 977 0.306440867353544 288 885676 SGTC_2079 5212404 121 µM 0.505205131997806 0.289817462752605 no 978 0.306707383081347 317 758462 SGTC_2830 7992007 71.43 µM 0.504794644907793 0.289962397657111 no 979 0.306851538713799 318 1952075 SGTC_1125 tnp00248 1.32998 µM 0.503156415614023 0.2905411623456 no 980 0.307427152516514 353 24207736 SGTC_2771 fluoxetine 41.05 µM 0.499935648617991 0.29168058999243 no 981 0.308560194980795 362 3386 A selective serotonin reuptake inhibitor. SGTC_3098 9119039 49.47 µM 0.499756497321532 0.291744030389763 no 982 0.308623272794215 331 17161528 SGTC_999 SEC7.066 22.7 µM 0.499585495338717 0.291804590979427 no 983 0.30868348656432 342 740511 YDR170C SEC7 SGTC_848 0368-0089 85.6 µM 0.499069243407021 0.291987457840746 no 984 0.30886530206377 349 762535 SGTC_3329 9141233 27.5565 µM 0.498921940713448 0.29203964521265 no 985 0.308917188259433 331 4909101 YNL103W MET4 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.495483355095118 0.29325912191243 no 986 0.310129484267321 352 165506 SGTC_2408 sulbentine 18.36 µM 0.494499751247775 0.293608385630455 no 987 0.31047664099381 312 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1102 cgs 12066b 26.1 µM 0.49365650218203 0.29390796459558 no 988 0.310774394865936 334 6438352 A 5-HT1B full agonist. SGTC_1495 4469-0029 237 µM 0.493518675677888 0.293956943307695 no 989 0.31082307362568 345 793680 SGTC_579 4491-1009 110 µM 0.492859047362475 0.29419140434579 no 990 0.311056092707033 367 1271041 SGTC_1108 betulinic acid 729.144 nM 0.491057062870833 0.294832349222635 no 991 0.311693044409367 310 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2945 9067681 61.76 µM 0.49097558410284 0.294861345475459 no 992 0.311721858237704 361 16456930 SGTC_433 pimozide 108 µM 0.489924544475029 0.295235501934454 no 993 0.312093647009067 335 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3303 9125618 40.5795 µM 0.488630112803155 0.295696602880529 no 994 0.312551795009022 347 22695467 SGTC_289 k017-0060 526 µM 0.488271585033161 0.29582437572925 no 995 0.312678742743915 346 5512909 SGTC_1553 gossypol 38.6 µM 0.486270510327798 0.296537988103947 no 996 0.313387692366987 356 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2596 sinensetin 100 µM 0.485744775908366 0.296725603400058 no 997 0.313574066462984 341 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3179 9107801 49.47 µM 0.48521169461596 0.296915896000274 no 998 0.31376309364604 304 4818259 SGTC_1607 st000305 50.6 µM 0.485165549822169 0.296932370809272 no 999 0.313779458592088 356 5457690 SGTC_1129 3453-1384 223 µM 0.485112258785495 0.296951397520454 no 1000 0.313798358361811 362 1084452 SGTC_725 1497-0963 19 µM 0.484173202538247 0.297286763985434 no 1001 0.314131476610837 347 3549977 SGTC_949 1165-0505 146 µM 0.483861067535249 0.297398275505401 no 1002 0.314242236086724 320 6244267 SGTC_1237 0330-0133 46.1 µM 0.481460313396897 0.298256592681974 no 1003 0.315094689706584 369 X1237 YHR072W ERG7 SGTC_2492 derrusnin 100 µM 0.481430606160442 0.298267220669658 no 1004 0.315105244258933 375 1715307 Part of coumarin class of compounds. SGTC_2177 5811945 192 µM 0.48116586932423 0.298361939882185 no 1005 0.315199308101633 347 5343475 SGTC_1779 st039427 55 µM 0.481127439158554 0.298375690806819 no 1006 0.315212963748569 368 1124498 SGTC_2779 methotrexate 400 µM 0.480068916387565 0.29875456043089 no 1007 0.315589194903973 359 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_839 0122-0028 230 µM 0.479982537720056 0.298785486988518 no 1008 0.315619904950783 359 759448 SGTC_2107 5363541 170.161 µM 0.479102822708961 0.299100538292194 no 1009 0.315932740876742 343 244052 SGTC_450 aminopyrene 156 nM 0.478707626009034 0.299242118695575 no 1010 0.316073319927623 363 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2301 7769476 200 µM 0.477755110292633 0.299583485209613 no 1011 0.31641225732571 342 977820 SGTC_2046 4110841 106 µM 0.477118703328988 0.29981166165801 no 1012 0.31663879849526 345 44119630 YMR134W ERG29 SGTC_410 α-linolenic acid 100 µM 0.476971298913833 0.299864523049131 no 1013 0.316691279717417 355 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1439 4092-1168 46 µM 0.474028726138934 0.300920654467518 no 1014 0.317739711333807 357 2886240 SGTC_2383 9036125 200 µM 0.473808002892509 0.300999942781922 no 1015 0.317818413587794 335 79580 SGTC_686 1319-0111 510 µM 0.47291831841089 0.301319631128639 no 1016 0.318135727640218 377 4562600 SGTC_33 0986-0033 35.816 µM 0.4722257832367 0.301568584023579 no 1017 0.318382819040422 331 2848082 SGTC_849 0386-0493 241 µM 0.470572989386741 0.302163104788137 no 1018 0.318972850032776 353 726119 SGTC_1871 st057448 67.3 µM 0.470306707857517 0.302258937185272 no 1019 0.319067952866702 376 691747 SGTC_2456 5770359 74.46 µM 0.470203573426516 0.30229605803012 no 1020 0.319104790678435 380 3118787 SGTC_25 0118-0223 35.662 µM 0.47011008256274 0.302329709664074 no 1021 0.319138185520637 361 5333628 SGTC_1877 wortmannin 25 µM 0.468899342071636 0.302765662201802 no 1022 0.319570793305667 371 312145 A covalent inhibitor of PI 3-kinase. SGTC_570 0987-0065 62.6 µM 0.468095929110352 0.30305510321702 no 1023 0.319857995157017 366 3104428 SGTC_607 4491-0986 66.8 µM 0.46712641038126 0.303404550943508 no 1024 0.320204719868339 336 698981 YDR232W HEM1 SGTC_1619 st003326 88.7 µM 0.465327115058461 0.304053555159512 no 1025 0.320848609958433 326 2849032 SGTC_2308 7584454 197.62 µM 0.465311664731791 0.304059130757251 no 1026 0.320854141300897 367 893577 SGTC_3077 9117319 49.47 µM 0.465085971030836 0.30414058259772 no 1027 0.320934946012 354 17154678 SGTC_168 3970-0862 530.542 µM 0.464512329362807 0.304347651037907 no 1028 0.321140364080435 361 3135186 SGTC_1262 0737-0114 49.6 µM 0.463789086221874 0.304608810800932 no 1029 0.321399431664517 355 765919 SGTC_215 1287-0124 461.5 µM 0.46277221346531 0.304976167355506 no 1030 0.321763825126903 363 5560863 SGTC_1292 0kpi-0043 232 µM 0.461785028667025 0.30533298693339 no 1031 0.32211774407521 363 3333905 SGTC_685 1278-0033 54.9 µM 0.461696707512513 0.305364919784085 no 1032 0.322149416258796 375 3590572 SGTC_2913 7966556 36.57 µM 0.461350730804079 0.305490023247381 no 1033 0.322273496795872 357 2976516 SGTC_29 0299-0004 12.984 µM 0.461339154851901 0.305494209447133 no 1034 0.32227764871948 344 16871 A napthoquinone isolated from Swertia calycina. SGTC_268 camptothecin 39.6153 µM 0.461067939247979 0.305592296145298 no 1035 0.322374931422078 348 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_601 0986-0029 62.9 µM 0.46068942937049 0.305729209764957 no 1036 0.322510719992964 353 24747981 SGTC_3233 9132340 49.47 µM 0.45921736434198 0.306261939433569 no 1037 0.323039041127017 381 17682950 SGTC_1921 5740136 50 µM 0.459192962841663 0.30627077361606 no 1038 0.32304780178833 373 1774243 SGTC_3047 9092122 49.47 µM 0.457935705413888 0.306726096360924 no 1039 0.323499316868974 353 17173831 SGTC_2712 st079126 47.7 µM 0.455869715970371 0.307474953746001 no 1040 0.324241833910972 356 3152970 SGTC_2143 5623677 140.463 µM 0.453657857404573 0.308277574508751 no 1041 0.325037551770633 347 5375313 SGTC_1653 st012112 65 µM 0.453049653312303 0.308498435515643 no 1042 0.325256493834117 354 720429 SGTC_1777 st045864 34.765 µM 0.452800790374454 0.308588826679549 no 1043 0.325346097222045 392 4691462 SGTC_1354 1498-1681 81 µM 0.44846110182572 0.310166934898625 no 1044 0.326910226503089 354 5754243 SGTC_908 3448-7491 47.7 µM 0.448459378415183 0.310167562306719 no 1045 0.326910848268986 319 1203031 SGTC_1288 0973-0013 65.5 µM 0.448162403559494 0.310275684337712 no 1046 0.327017996971266 349 4315430 SGTC_297 0986-0032 24 µM 0.447733859760912 0.310431736642781 no 1047 0.327172640962266 363 2847425 SGTC_230 MPP+ 141.667 µM 0.443980617603894 0.31179991881739 no 1048 0.328528298629073 355 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2147 5545932 89.7195 µM 0.44359714382608 0.311939854611098 no 1049 0.328666935547644 378 797404 SGTC_2375 9072683 200 µM 0.442708951799961 0.312264074506813 no 1050 0.328988133335116 373 16798029 SGTC_2582 agaric acid 100 µM 0.440355597166465 0.313123830574287 no 1051 0.329839789598896 332 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2458 5808907 16.39 µM 0.438256474412108 0.313891565976917 no 1052 0.330600187022582 398 2731747 SGTC_2436 5633522 8.09 µM 0.437869895061815 0.314033041947679 no 1053 0.330740299980083 353 5724242 SGTC_1922 5578187 25 µM 0.43678604459432 0.314429843085465 no 1054 0.331133260354363 323 1350412 SGTC_190 3970-0790 3.722 µM 0.436631669831146 0.314486377643259 no 1055 0.331189245551911 358 2832352 SGTC_1836 st055642 81 µM 0.435255168862419 0.314990666980964 no 1056 0.331688610955133 391 8571 SGTC_294 k038-0071 157 µM 0.434118434878885 0.315407376470011 no 1057 0.33210121962706 351 24152826 SGTC_962 1254-0300 21.5 µM 0.433806844107334 0.315521641976228 no 1058 0.332214355597603 344 7340576 SGTC_566 0958-0068 16.5 µM 0.431920762539115 0.316213675649035 no 1059 0.332899501986475 358 6815365 SGTC_3006 9075424 71.4286 µM 0.431265317447985 0.316454319977711 no 1060 0.33313773272877 366 7465181 SGTC_994 3910-0338 138 µM 0.43017619530754 0.316854359149402 no 1061 0.333533738393707 364 3479481 SGTC_751 0833-0568 350 µM 0.430034897034266 0.316906274312099 no 1062 0.333585128164715 381 6954252 SGTC_1409 3909-8004 61.9 µM 0.42615101961365 0.318334679242024 no 1063 0.334998902770358 356 2119279 SGTC_3204 9114183 49.47 µM 0.425098770843515 0.318722139897195 no 1064 0.335382336956417 340 17027248 SGTC_2362 9071156 126 µM 0.423131842433163 0.31944693673246 no 1065 0.336099535607062 353 653133 SGTC_2904 7225135 42.03 µM 0.422053159702155 0.319844715702223 no 1066 0.336493108029652 391 4446116 SGTC_1256 0570-0116 285 µM 0.420859407195233 0.320285169832169 no 1067 0.336928874164017 360 410638 SGTC_1070 indatraline 8.81 µM 0.419523593736935 0.320778339960082 no 1068 0.337416757676956 394 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1341 1486-1360 280 µM 0.419045521204811 0.320954916913728 no 1069 0.337591432161014 355 3976547 SGTC_2417 cerulenin 830 nM 0.418557570781906 0.321135184051885 no 1070 0.337769751841885 356 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.418389301517729 0.321197358790141 no 1071 0.337831253671041 356 688664 SGTC_563 tetrahydrosecaminediol 614 µM 0.416688727317222 0.321825994366633 no 1072 0.338453050371418 363 334274 A psychoactive constituent of the cannabis plant. SGTC_319 1348-1596 45.5 µM 0.416427022035992 0.321922781899269 no 1073 0.338548779269936 387 5380505 SGTC_2233 sulbentine 40.3845 µM 0.416114597293038 0.322038343038603 no 1074 0.338663074448494 363 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2427 5545055 42.75 µM 0.415518369576123 0.322258926314383 no 1075 0.3388812352582 372 5372858 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.41544298965191 0.322286818693633 no 1076 0.338908820760382 368 97141 SGTC_3209 9113616 49.47 µM 0.414328938165155 0.322699161060362 no 1077 0.33931661179771 400 16649353 SGTC_257 daunorubicin 18.5 µM 0.410000536209709 0.324303292877992 no 1078 0.340902777100456 390 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2936 9038235 15.59 µM 0.40894626999775 0.324694506117761 no 1079 0.341289546042038 354 4749415 SGTC_1740 st038286 13.222 µM 0.407644738548933 0.325177740472808 no 1080 0.341767256917403 342 716786 SGTC_3338 9144300 39.5675 µM 0.406154662906099 0.325731338941799 no 1081 0.342314481818151 346 4901274 SGTC_85 0868-0259 160.055 µM 0.40599028380001 0.325792433252238 no 1082 0.342374869758486 380 83173 SGTC_2275 7947463 200 µM 0.404444885494778 0.326367035570068 no 1083 0.342942799488905 366 1225414 SGTC_1884 5633444 25 µM 0.4027242666829 0.327007272603338 no 1084 0.343575539990469 358 5724239 SGTC_2104 5389443 200 µM 0.402262642900357 0.327179128172291 no 1085 0.343745372243772 381 2244536 SGTC_2575 plumbagin 510 nM 0.399977682806781 0.328030323373707 no 1086 0.344586477182237 363 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2224 6650123 117.647 µM 0.399757760746452 0.32811229614825 no 1087 0.344667472194842 394 2908370 SGTC_1843 st055809 45.5 µM 0.39825423588084 0.328672934952947 no 1088 0.345221395387116 363 16413835 SGTC_1726 st035556 14.5795 µM 0.395789918314015 0.329592671039271 no 1089 0.346130007412023 349 5919439 SGTC_1085 doxorubicin 7.67 µM 0.394909050445423 0.329921680377003 no 1090 0.346455005229844 396 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2052 5265182 7.135 µM 0.393810537554273 0.330332165807387 no 1091 0.346860461987279 399 1239884 SGTC_2034 5197015 53.07 µM 0.393369150812496 0.330497157998191 no 1092 0.347023425517343 396 780676 SGTC_3323 9138564 53.9225 µM 0.392492964987871 0.330824777487309 no 1093 0.347347004174503 362 43912313 YNL103W MET4 SGTC_3156 9099931 49.47 µM 0.392367439106033 0.330871724185243 no 1094 0.3473933704652 374 18111053 SGTC_3091 9116372 49.47 µM 0.391179694623108 0.331316072364892 no 1095 0.347832208124572 355 17169793 SGTC_1414 3917-0015 5.4 µM 0.387971763354708 0.332517380471874 no 1096 0.349018464853653 397 6618702 SGTC_475 α-linolenic acid 10 µM 0.386896364090413 0.332920482723587 no 1097 0.349416466494986 368 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_816 0325-0417 81.3 µM 0.386393355788195 0.333109096502088 no 1098 0.349602685049715 383 68101 SGTC_1735 st034310 56.75 µM 0.385842680143352 0.333315632589784 no 1099 0.349806592020367 422 871153 SGTC_2658 polymyxin b sulfate 77.05 µM 0.385116549898607 0.333588051846514 no 1100 0.35007553343879 368 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_501 nsc-95397 161 µM 0.384624857850039 0.33377256774977 no 1101 0.350257687229077 401 262093 SGTC_2334 9017922 200 µM 0.38366223047116 0.334133926616704 no 1102 0.350614404925173 386 3163164 SGTC_2490 carminic acid 95.39 µM 0.383616958787365 0.334150924857607 no 1103 0.350631184352174 372 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_753 1322-0200 289 µM 0.382498334029784 0.334571044888924 no 1104 0.35104588219143 367 5403907 SGTC_1811 st050069 61.5 µM 0.382030237196864 0.334746908764295 no 1105 0.351219468277464 396 3877702 SGTC_2981 9013952 38.96 µM 0.381818388397363 0.33482651222975 no 1106 0.351298039160436 336 2996344 SGTC_985 1493-0307 8.71 µM 0.381700487742124 0.334870817327983 no 1107 0.351341769131212 414 3278274 SGTC_832 4083-0019 164 µM 0.381314195607313 0.335015995563817 no 1108 0.351485060692513 362 1990758 SGTC_1105 epirubicin 18.1 µM 0.381134476515393 0.335083546893635 no 1109 0.351551733054223 376 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_693 4161-2696 114 µM 0.38076243918115 0.335223402168048 no 1110 0.351689766333215 380 805759 SGTC_1291 0993-0025 5.79 µM 0.380391362587306 0.335362919039252 no 1111 0.351827462637551 388 4353356 SGTC_1652 st011932 78 µM 0.378277933359597 0.336157955766348 no 1112 0.352612068145256 389 1551076 SGTC_3277 9138724 49.47 µM 0.378091421128341 0.336228153817944 no 1113 0.352681340538474 390 15943418 SGTC_419 nsc-638432 893 µM 0.377599777631168 0.336413222211101 no 1114 0.352863964953017 361 368090 SGTC_2396 5342950 42.78 µM 0.376627605815057 0.336779291592009 no 1115 0.353225184746459 404 1886677 SGTC_2979 9012552 45.46 µM 0.376457688691182 0.336843289441053 no 1116 0.353288332678073 404 17100905 SGTC_1806 st050005 60.3 µM 0.376323058513014 0.336894000114732 no 1117 0.353338369451711 386 5194765 SGTC_3064 1327-0027 10 µM 0.375704344197966 0.337127087161932 no 1118 0.35356835395758 402 16000455 YPR107C YTH1 SGTC_78 0336-0123 156.75 µM 0.375629741156355 0.337155196448376 no 1119 0.353596088534021 366 6765896 SGTC_3113 9123498 49.47 µM 0.37384519592703 0.337827856504176 no 1120 0.354259746002625 409 8897275 SGTC_1981 st071826 47 µM 0.373590552768465 0.337923883083117 no 1121 0.354354481817967 368 11838600 SGTC_346 4513-0042 7.16 µM 0.37329980410818 0.338033538036131 no 1122 0.354462661113747 370 2827372 SGTC_106 0092-0003 11.579 µM 0.372643862880917 0.338280974698173 no 1123 0.354706761277787 383 1072148 SGTC_2926 9010726 65.15 µM 0.3717036204206 0.338635778377722 no 1124 0.355056764572038 370 2994293 SGTC_1348 1493-0373 93.8 µM 0.370756635599235 0.338993271120774 no 1125 0.355409401359155 410 3010129 SGTC_802 4112-3352 742 µM 0.370309408270328 0.339162152700827 no 1126 0.355575982268027 345 704594 SGTC_2571 chrysanthemic acid 100 µM 0.370040497002816 0.339263714292287 no 1127 0.355676158222151 393 2743 An insecticide. SGTC_843 0310-0051 143 µM 0.368742621075138 0.339754056225799 no 1128 0.356159788463035 408 2065037 SGTC_1353 1498-1206 8.11 µM 0.365600188233636 0.340942400332061 no 1129 0.35733171731269 399 6756808 SGTC_2975 9084847 53.72 µM 0.365387531566642 0.341022875894803 no 1130 0.35741107359036 356 27211724 SGTC_162 k030-0015 37.8 µM 0.364742666604411 0.341266956051295 no 1131 0.357651753078226 404 1809920 YMR134W ERG29 SGTC_2075 5212009 200 µM 0.362509895222914 0.342112568332366 no 1132 0.358485515182738 424 780898 SGTC_1813 st051246 8.6015 µM 0.362264238113179 0.342205653940193 no 1133 0.358577289819577 384 5291959 SGTC_1374 2889-5571 141 µM 0.361577614432001 0.342465883625704 no 1134 0.358833847738072 367 2853281 SGTC_2477 5967686 25.23 µM 0.359898404386334 0.343102617497763 no 1135 0.35946155515405 397 776118 SGTC_2311 7694451 200 µM 0.359439350856424 0.343276762086109 no 1136 0.359633220588591 434 2163142 SGTC_2726 cimetidine 79.27 µM 0.358967657134583 0.343455736474841 no 1137 0.359809642395989 413 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_580 1123-0028 41 µM 0.358500949949149 0.343632853378052 no 1138 0.359984228553257 401 1677248 YPR107C YTH1 SGTC_752 1896-0090 130 µM 0.358493459608481 0.343635696266865 no 1139 0.359987030783522 394 772567 SGTC_1617 st002906 78 µM 0.357580832641481 0.343982141443398 no 1140 0.360328512232456 406 5150859 SGTC_932 2857-0803 154 µM 0.357045171649595 0.344185546426658 no 1141 0.360528994669829 402 674898 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.356389285234358 0.344434665655652 no 1142 0.360774526228386 401 5357218 A potent inhibitor of glutathione S-transferases. SGTC_408 cantharidin 100 µM 0.355555638940166 0.344751399174479 no 1143 0.361086685158449 376 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1802 st050112 57.9 µM 0.355543310283013 0.344756084111388 no 1144 0.361091302320098 375 4662563 SGTC_3143 9086658 49.47 µM 0.355038922256274 0.344947773895317 no 1145 0.36128021623509 389 25236626 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.354923995785568 0.344991456612445 no 1146 0.361323265626195 397 279621 SGTC_1691 st019933 84.6 µM 0.354002373407548 0.345341833255712 no 1147 0.361668552273078 421 6176082 SGTC_2286 7945697 125 µM 0.353052127775547 0.34570323053763 no 1148 0.362024680618452 384 1245733 SGTC_2317 5986382 200 µM 0.352692066528121 0.345840205742431 no 1149 0.362159653820084 414 877883 SGTC_2342 7990637 118.86 µM 0.351547695919305 0.346275683363209 no 1150 0.362588748370486 402 2033102 YER133W GLC7 SGTC_1300 1094-0077 113 µM 0.351147533710147 0.346428008688599 no 1151 0.36273883443238 388 5532636 SGTC_1965 Pectolinarigenin 58.4 µM 0.350916737245793 0.346515874724265 no 1152 0.362825407251576 381 5320438 An anti-inflammatory. SGTC_2110 5483698 200 µM 0.350232557910216 0.346776395712059 no 1153 0.363082087265647 359 2848765 YHR062C RPP1 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.34960577906548 0.347015123416262 no 1154 0.363317286626577 436 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2487 5918373 44.05 µM 0.348713387133196 0.347355122682853 no 1155 0.3636522464694 430 2876279 SGTC_2397 5161689 200 µM 0.346792631692526 0.34808734260651 no 1156 0.364373556539321 378 2259942 SGTC_1526 st051518 75 µM 0.346424521205886 0.348227736477848 no 1157 0.36451184970734 384 673993 SGTC_5 0352-0601 109.883 µM 0.345774258020105 0.34847579154646 no 1158 0.364756186174626 389 762456 SGTC_736 0958-0254 92.6 µM 0.342804816952259 0.349609362793271 no 1159 0.365872650949938 424 6812352 SGTC_3268 9137683 49.47 µM 0.341260453824987 0.350199447981117 no 1160 0.366453758066781 441 1953228 SGTC_3158 9100007 49.47 µM 0.340849455413522 0.350356547244726 no 1161 0.366608458656406 369 19297233 SGTC_2047 4141938 200 µM 0.340657876956384 0.350429784586403 no 1162 0.366680576562012 424 3807862 SGTC_181 1447-1644 8.07 µM 0.338820629682079 0.351132416492945 no 1163 0.367372429659418 400 534600 SGTC_227 fluconazole 33.516 µM 0.338296492064931 0.351332959736866 no 1164 0.36756988348946 417 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3322 9139058 2.11 µM 0.337023985540945 0.351820012782783 no 1165 0.368049409464475 363 4908926 YPR165W RHO1 SGTC_2370 9071495 200 µM 0.336774735284457 0.351915442065871 no 1166 0.368143359989375 413 21791103 SGTC_2526 patulin 37.61 µM 0.336000393922236 0.352211970017873 no 1167 0.368435284709329 364 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2150 5556613 200 µM 0.335777475619046 0.352297351502271 no 1168 0.368519338430118 403 743190 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.335183225357291 0.352524995778962 no 1169 0.368743437553188 402 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2951 9072950 58.06 µM 0.334285168647596 0.352869121887658 no 1170 0.369082190531103 416 16488155 SGTC_1578 josamycin 24.2 µM 0.33359321330092 0.353134354212085 no 1171 0.36934327008969 373 5282165 A P450 substrate. SGTC_2035 5154463 94.595 µM 0.332410184810314 0.353587984264781 no 1172 0.369789774508224 438 2769623 SGTC_466 geldanamycin 89.2 µM 0.332207146776858 0.353665859748645 no 1173 0.369866423791833 399 5288382 HSP90 inhibitor. SGTC_134 0269-0018 6.916 µM 0.332146516780982 0.353689115644704 no 1174 0.3698893133423 400 4378915 SGTC_41 0478-0632 82.643 µM 0.331723105888001 0.353851538917649 no 1175 0.370049175860792 438 3750424 SGTC_2683 piperine 63.03 µM 0.331101422596364 0.354090069019929 no 1176 0.370283938555372 418 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1875 nocodazole 6 µM 0.330904441937347 0.354165659352776 no 1177 0.370358333317742 403 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2203 7227154 166.4 µM 0.32960207047029 0.354665582305767 no 1178 0.370850328972298 391 896304 SGTC_2276 7947513 42.08 µM 0.329581669102127 0.354673415485333 no 1179 0.370858037660509 399 2105100 SGTC_2899 9053889 58.44 µM 0.329333441458214 0.354768728314426 no 1180 0.370951835007158 425 6470052 SGTC_2004 4023728 41.89 µM 0.327763342207128 0.355371815180797 no 1181 0.371545303108473 436 360084 YDR527W RBA50 SGTC_2799 7812892 81.82 µM 0.327679958565308 0.355403853607331 no 1182 0.371576829117084 403 20205235 SGTC_100 0086-0128 49.5915 µM 0.32516515824718 0.356370592442591 no 1183 0.372528038368196 417 93297 SGTC_3019 9081971 49.47 µM 0.325143998693794 0.356378730519549 no 1184 0.372536045160481 405 16451803 SGTC_595 3909-8003 73.7 µM 0.322368067006897 0.357446934488674 no 1185 0.373586936426442 415 699517 SGTC_3191 9110352 49.47 µM 0.32169370643145 0.357706603710128 no 1186 0.373842373080628 393 17122424 SGTC_1029 k015-0030 64.7 µM 0.320885119872439 0.3580180448142 no 1187 0.37414872537649 396 2208316 SGTC_2393 9031399 185.94 µM 0.320863377965154 0.358026420391764 no 1188 0.374156963914765 408 1526623 YDL150W RPC53 SGTC_1937 st074714 47.2 µM 0.320494227114211 0.358168637826743 no 1189 0.374296852933532 398 17250970 SGTC_1378 2093-0007 380 nM 0.320479194435553 0.358174429667658 no 1190 0.374302549889603 435 3618014 SGTC_1267 0828-0272 9.49 µM 0.31959446127539 0.358515360073764 no 1191 0.37463788680282 405 745334 SGTC_1787 fluconazole 80 µM 0.318765579646027 0.358834870537309 no 1192 0.374952140576534 397 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_150 3970-0969 77.2 µM 0.318033717698672 0.359117064794347 no 1193 0.375229680329892 407 6615640 SGTC_1101 ebselen 5.29 µM 0.316792992161893 0.359595644302107 no 1194 0.375700340999636 426 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3080 9117754 49.47 µM 0.315908450395147 0.359936969191973 no 1195 0.376035998830734 411 9550191 SGTC_2944 9067346 25.62 µM 0.315421535688721 0.36012490638271 no 1196 0.376220808823457 404 6473075 SGTC_1476 4112-3294 3.34 µM 0.315372447091724 0.360143855259799 no 1197 0.376239442129056 423 704369 SGTC_1507 4075-3230 155 µM 0.315340319202433 0.360156257255278 no 1198 0.376251637556975 425 659771 SGTC_2750 bromebric acid 70.15 µM 0.315145832903431 0.360231335923432 no 1199 0.376325465263277 393 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1498 4478-3555 97.6 µM 0.314452174985564 0.360499156573957 no 1200 0.376588817165095 418 3437919 SGTC_3196 9111891 49.47 µM 0.312537133997346 0.361238907054135 no 1201 0.377316173269583 428 18891510 SGTC_2218 6965428 192.983 µM 0.311659460106148 0.361578112464303 no 1202 0.377649670268521 399 675684 SGTC_2455 5377712 9.75 µM 0.311542108543425 0.361623475017338 no 1203 0.377694268231321 370 2243908 SGTC_1441 4106-0040 13 µM 0.310337559577085 0.362089208897653 no 1204 0.378152135848122 396 2904180 SGTC_1524 corynanthine 62.1 µM 0.31031357196004 0.362098485687279 no 1205 0.378161255651361 418 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_360 0957-0399 1.01 µM 0.310255475654619 0.362120953748792 no 1206 0.378183343448616 397 6752301 YPR165W RHO1 SGTC_1357 1503-1303 39.5 µM 0.309957041489447 0.362236377132444 no 1207 0.37829681224461 388 292895 SGTC_2611 pyromycin 23.93 µM 0.307333328737973 0.363251671059202 no 1208 0.379294834879698 382 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1708 st033234 31.827 µM 0.30629844990718 0.36365240130527 no 1209 0.379688709666404 385 674664 SGTC_925 2064-1272 59.6 µM 0.304474390576234 0.364359084480034 no 1210 0.380383250257017 420 6815817 SGTC_3271 9137798 49.47 µM 0.304468878865484 0.364361220545763 no 1211 0.380385349517296 400 6498326 SGTC_2630 antimycin a 100 µM 0.303505747143284 0.364734547263953 no 1212 0.38075223416019 401 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3230 9131665 49.47 µM 0.302640993661834 0.36506985018134 no 1213 0.381081735090832 436 15943720 SGTC_1392 3455-1037 33.9 µM 0.302043293365288 0.365301665175766 no 1214 0.381309529958183 431 981132 SGTC_1789 tunicamycin 25 nM 0.301426016437797 0.365541124533865 no 1215 0.381544829018833 429 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2018 5133068 143 µM 0.300675601335761 0.365832302578581 no 1216 0.38183093782325 426 785362 SGTC_1745 st081495 74 µM 0.3006664341352 0.365835860138194 no 1217 0.381834433377314 399 13842402 YBL026W LSM2 SGTC_1206 3978-0017 132 µM 0.300329835496762 0.365966493577398 no 1218 0.381962788797312 424 3873677 SGTC_71 0417-1750 47.813 µM 0.300089157128873 0.366059910029314 no 1219 0.382054574823222 404 6811472 SGTC_149 3970-0822 46.1 µM 0.297591284551428 0.367029897519573 no 1220 0.383007563641875 405 3114250 YBL034C STU1 SGTC_2443 5493264 126.67 µM 0.296186996919692 0.367575591579629 no 1221 0.383543639265751 424 5340055 SGTC_26 0302-0163 425.158 µM 0.29613092134212 0.36759738762629 no 1222 0.383565050308013 434 3100915 SGTC_1709 st033179 39.1045 µM 0.295957921106892 0.367664633868758 no 1223 0.383631108316349 418 573381 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.295281561963677 0.367927577698329 no 1224 0.383889400165928 374 688803 SGTC_426 0988-0037 14.6 µM 0.289193140350752 0.370297307523903 no 1225 0.386216790451473 447 5383008 SGTC_893 0958-0369 48.9 µM 0.286088011134275 0.371507787751497 no 1226 0.387405356855059 439 6819948 SGTC_3178 9107506 49.47 µM 0.286066894307442 0.371516024143773 no 1227 0.387413443480487 417 8897194 SGTC_1620 st003704 16.5 µM 0.284790829383926 0.372013848663142 no 1228 0.387902199256909 426 2834414 SGTC_281 1672-3440 14.9 µM 0.284420668565706 0.372158297646731 no 1229 0.388044010769597 435 6833000 SGTC_2020 4017018 200 µM 0.28407947141817 0.372291459984639 no 1230 0.388174739297469 425 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_376 3970-0862 59.1 µM 0.283679981087036 0.372447392379059 no 1231 0.3883278187637 427 3135186 SGTC_907 3448-6986 75.5 µM 0.283321475588734 0.372587345036815 no 1232 0.388465208149614 410 590582 SGTC_413 propylparaben 100 µM 0.283206033939366 0.372632414498326 no 1233 0.388509451606385 398 7175 A pharmaceutical preservative. SGTC_469 w7 172 µM 0.280817348121861 0.373565369521399 no 1234 0.389425248471918 427 45115570 A P450 inhibitor. SGTC_1420 4'-methoxyflavone 42 µM 0.279616193900586 0.374034787873609 no 1235 0.389885990786685 434 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2193 5925765 200 µM 0.279519490800492 0.374072588167985 no 1236 0.389923091189905 407 877370 SGTC_2160 5660466 132.927 µM 0.27951165070069 0.374075652839254 no 1237 0.389926099109134 436 2859134 SGTC_1456 k015-0012 13 µM 0.277718515417367 0.374776792707638 no 1238 0.390614223128607 426 2989616 SGTC_1647 st011722 22.4 µM 0.277385088455636 0.374907212839407 no 1239 0.390742215133117 404 2854783 SGTC_57 miconazole 162.5 nM 0.277133442902474 0.375005653604325 no 1240 0.390838821695888 433 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2709 st078560 56 µM 0.27643008073717 0.375280843737279 no 1241 0.391108877685439 431 17250903 SGTC_1758 st042942 75.2445 µM 0.272383066642172 0.376865465750244 no 1242 0.392663745757049 424 669317 SGTC_2793 7325131 81.82 µM 0.271576187226107 0.377181651231549 no 1243 0.392973955673319 424 4176441 SGTC_1282 0886-0010 32.4 µM 0.270690751589914 0.377528714695636 no 1244 0.39331444525418 447 2836211 YNL267W PIK1 SGTC_2900 5328528 85.29 µM 0.270633276848486 0.377551246443627 no 1245 0.393336549684944 441 795359 SGTC_296 1222-0039 74.9 µM 0.267757007099588 0.378679357490895 no 1246 0.394443183007271 409 5984176 SGTC_1176 0848-0131 83.3 µM 0.265004790479707 0.379759782090803 no 1247 0.395502885723659 455 6769040 SGTC_458 nppb 133 µM 0.261191261400752 0.381258392145065 no 1248 0.396972508341118 407 4549 A chloride channel blocker. SGTC_2264 7948757 110.76 µM 0.260891714009002 0.381376181662772 no 1249 0.397088007445473 400 2971411 SGTC_2749 bexarotene 57.39 µM 0.260719976255341 0.381443718194575 no 1250 0.397154229942966 413 82146 An retinoic acid receptor inhibitor. SGTC_517 1365-0151 113 µM 0.260682465618969 0.381458469876956 no 1251 0.397168694530638 413 768657 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.259390422632398 0.381966692280537 no 1252 0.3976670092684 425 77254 SGTC_1154 4088-0362 150 µM 0.258786128351065 0.382204460063488 no 1253 0.397900130677134 425 6618304 SGTC_91 0417-1751 58.384 µM 0.258757191846253 0.382215846639196 no 1254 0.397911294562205 456 6795624 SGTC_2094 5332512 191.667 µM 0.25773483648229 0.382618210940892 no 1255 0.398305779259264 448 755774 SGTC_3068 9116768 49.47 µM 0.257698201331208 0.382632631645148 no 1256 0.398319917182191 451 41904888 SGTC_618 k072-0232 33.2 µM 0.257652078641308 0.382650787163235 no 1257 0.398337716644428 442 5872756 YGL099W LSG1 SGTC_220 paclitaxel 373.376 µM 0.257511783669818 0.38270601379919 no 1258 0.398391859952568 436 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_602 3130-1533 38.1 µM 0.256692495980005 0.383028571197549 no 1259 0.398708082420178 443 720941 SGTC_1986 st071812 45 µM 0.255177381742797 0.383625292352293 no 1260 0.399293049838289 454 11838594 SGTC_2992 9074591 71.4286 µM 0.25508370318512 0.383662196322752 no 1261 0.39932922544314 419 17741321 SGTC_514 4466-0038 2.65 nM 0.254812571459631 0.383769012593708 no 1262 0.399433932546689 412 5722064 SGTC_2005 4024620 188 µM 0.254783651664042 0.383780406487539 no 1263 0.399445101375508 453 236743 SGTC_2081 5214970 32.255 µM 0.254471487428159 0.383903400132409 no 1264 0.399565664480627 420 2063512 SGTC_2681 menadione 3.18 µM 0.254418970684563 0.383924093036429 no 1265 0.399585948276284 438 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_554 4483-2211 187 µM 0.254056661512738 0.384066860881807 no 1266 0.399725892080175 418 747107 SGTC_2078 5212016 200 µM 0.252709210091971 0.384597961722985 no 1267 0.400246465112813 467 1899708 SGTC_1612 st002233 45.4 µM 0.252237275131274 0.384784027173931 no 1268 0.40042883396015 454 1035021 SGTC_31 0508-1974 57.237 µM 0.250488655690109 0.385473670285214 no 1269 0.401104738289954 422 6810525 SGTC_3148 9097893 49.47 µM 0.250336777066123 0.38553358726795 no 1270 0.401163458847372 384 17174100 SGTC_7 0192-1582 4.227 µM 0.249910340201205 0.385701833640522 no 1271 0.401328343291133 447 252616 SGTC_2040 5100729 123 µM 0.249620976727836 0.385816011336128 no 1272 0.401440237472186 434 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_17 0960-0276 49.807 µM 0.248937959748443 0.386085556944791 no 1273 0.401704385865523 427 6821114 SGTC_634 1611-4317 11.2 µM 0.248506848628858 0.386255718823598 no 1274 0.401871135904292 440 2843522 SGTC_2995 9067767 71.4286 µM 0.248174404581709 0.386386951221405 no 1275 0.401999734577654 421 11673567 SGTC_205 1486-1330 71.903 µM 0.247519045779909 0.386645692376871 no 1276 0.402253276789434 429 4118834 SGTC_1898 st060199 18.6 µM 0.247513904168768 0.386647722527501 no 1277 0.402255266115152 415 688866 SGTC_1241 0364-0022 50.8 µM 0.24706722669405 0.386824103701552 no 1278 0.40242809844765 442 4563895 SGTC_822 1487-0950 154 µM 0.246622072730504 0.386999906539973 no 1279 0.402600360267235 446 1958375 SGTC_2740 felodipine 17.08 µM 0.24590400930687 0.387283537246321 no 1280 0.402878270067851 456 3333 L-type calcium channel blocker SGTC_696 1560-0013 611 µM 0.245719763499153 0.387356322933385 no 1281 0.40294958605324 394 1650269 SGTC_2136 5328288 199.296 µM 0.245298249070212 0.387522855680666 no 1282 0.403112753692329 421 262395 SGTC_2677 mitomycin C 100 µM 0.245237758909171 0.387546755951018 no 1283 0.403136170733071 433 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1401 3807-4679 7.6 µM 0.245173101094609 0.387572303374355 no 1284 0.403161201546122 428 3291456 SGTC_2156 5649887 115 µM 0.243979660924513 0.3880439395801 no 1285 0.40362328611445 441 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3257 9139206 32.98 µM 0.243654596072602 0.388172430770436 no 1286 0.403749170356822 444 4910041 SGTC_2834 9001755 58.44 µM 0.24266517420963 0.388563603375238 no 1287 0.404132394044372 447 2989575 SGTC_1522 st012842 45.6 µM 0.242009434827397 0.388822915344185 no 1288 0.404386426285408 463 3491067 YOR116C RPO31 SGTC_699 0375-0592 111 µM 0.241557466453883 0.389001674968806 no 1289 0.404561541486196 441 762578 SGTC_362 0310-0100 9.03 µM 0.240383915966938 0.389465939750714 no 1290 0.405016322953818 405 790235 SGTC_902 1120-0002 2.07 µM 0.240252901731104 0.389517779702836 no 1291 0.405067102365221 421 3280475 SGTC_1927 st060202 13.8 µM 0.239910435434587 0.38965329667642 no 1292 0.405199845388968 457 688887 SGTC_2221 6807166 181.081 µM 0.238660815378982 0.390147896184536 no 1293 0.405684301784689 432 674925 SGTC_787 4152-0075 138 µM 0.238532069540372 0.390198863896919 no 1294 0.405734222574851 410 9566539 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.237918617535672 0.390441742278212 no 1295 0.405972107684368 469 368090 SGTC_99 0109-0120 622.8 µM 0.237215831666619 0.39072004234091 no 1296 0.406244677450475 454 759414 SGTC_1422 4031-0024 15.5 µM 0.236609426415071 0.390960221111721 no 1297 0.406479903308351 462 782427 SGTC_385 1494-0393 12.4 µM 0.234581944877292 0.391763546746795 no 1298 0.407266612229724 442 3090647 SGTC_2103 5378138 10 µM 0.234091084260345 0.39195810434231 no 1299 0.407457133695204 459 244142 SGTC_934 2950-0684 338 µM 0.234036626670548 0.391979690827553 no 1300 0.407478272083803 464 1121253 SGTC_2186 6124449 200 µM 0.233038236430203 0.392375502352613 no 1301 0.407865857318003 458 3834182 YLR033W RSC58 SGTC_1701 st028638 40.4 µM 0.23275124858232 0.39248929922741 no 1302 0.407977285620373 439 3490878 SGTC_3075 9116269 49.47 µM 0.23160677529984 0.392943198918284 no 1303 0.408421722331752 451 17015205 YNL244C SUI1 SGTC_1075 aripiprazole 15.2 µM 0.231475723744071 0.392995183449518 no 1304 0.408472621500496 413 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.231413031720618 0.393020052317928 no 1305 0.408496971027843 460 688798 SGTC_1878 temozolomide 1 mM 0.231349544142548 0.39304523721441 no 1306 0.408521629907923 459 5394 DNA alkylating agent. SGTC_3172 9105863 49.47 µM 0.22992773887993 0.393609370438232 no 1307 0.409073960602033 459 2348785 SGTC_510 ag-490 170 µM 0.227905188100598 0.394412247620313 no 1308 0.409859974667669 450 5328779 SGTC_3032 9089427 49.47 µM 0.227347656835913 0.394633645778223 no 1309 0.410076709176377 467 17173707 SGTC_2432 5630864 12.22 µM 0.226977269040516 0.394780747249009 no 1310 0.410220708790739 437 5714970 SGTC_2854 9024559 71.43 µM 0.226826191451626 0.394840752820729 no 1311 0.410279448313836 431 3163529 SGTC_425 3825-7017 13.1 µM 0.226821179795354 0.394842743412197 no 1312 0.410281396898758 476 3397440 SGTC_2629 bisabolol 100 µM 0.226744489858337 0.394873204409887 no 1313 0.410311215032998 470 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3201 9113999 49.47 µM 0.226614962650247 0.394924653661807 no 1314 0.41036157822431 427 16649224 SGTC_3246 9135460 32.98 µM 0.226272181079793 0.395060818105148 no 1315 0.410494866802698 463 41446951 SGTC_2563 tomatine 8.54 µM 0.22529931829151 0.39544734189096 no 1316 0.410873214981649 470 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1278 0874-0585 172 µM 0.224873537463389 0.395616539363588 no 1317 0.4110388280635 429 766306 SGTC_1068 loratadine 26.9 µM 0.224527996360721 0.395753865508646 no 1318 0.411173242501327 438 3957 A H1 histamine antagonist. SGTC_2217 6934799 96.0675 µM 0.223851387160718 0.396022803353467 no 1319 0.411436471611262 447 675606 SGTC_804 1595-0054 20.9 µM 0.222776965858457 0.396449964755857 no 1320 0.411854548049546 438 761523 Stimulates phospholipase C. SGTC_3290 9121031 71.43 µM 0.221303268165694 0.397036069978688 no 1321 0.412428152720567 434 17014854 SGTC_2473 5854593 8.94 µM 0.220992797469646 0.397159577183027 no 1322 0.412549020565372 438 2872951 SGTC_864 0469-0573 172 µM 0.220706053894205 0.397273654750804 no 1323 0.412660658686651 451 689425 SGTC_2450 5739737 12.93 µM 0.22069747383825 0.397277068360881 no 1324 0.412663999276082 459 2262825 SGTC_746 1095-0025 46.6 µM 0.219489728508423 0.397757653130777 no 1325 0.413134290133521 471 6749286 SGTC_509 pifithrin 175 µM 0.218605893083311 0.398109446397779 no 1326 0.413478530908127 452 4817 A p53 inhibitor. SGTC_2240 6690706 185.951 µM 0.218602950525223 0.398110617763539 no 1327 0.41347967710205 403 805876 SGTC_2181 6316240 54.2555 µM 0.218039955417648 0.398334750254382 no 1328 0.413698990174597 425 12779990 SGTC_1587 estradiol valerate 56.1 µM 0.217850423286308 0.398410211939938 no 1329 0.413772827914468 462 13791 A steroid. SGTC_2236 dapsone 200 µM 0.217194124884273 0.398671544641426 no 1330 0.414028531536281 449 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3108 9121785 49.47 µM 0.216274519392682 0.399037800509537 no 1331 0.414386884815975 461 17140271 SGTC_647 0140-0236 81 µM 0.216016540809222 0.399140562909895 no 1332 0.414487427121628 448 990837 SGTC_2459 5811157 9.22 µM 0.215956453915609 0.39916449874333 no 1333 0.414510845664162 434 2870684 YBR192W RIM2 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.215209477890983 0.399462090994598 no 1334 0.414802000883893 456 689007 SGTC_229 benomyl 22.8748 µM 0.214070321885422 0.399916038612204 no 1335 0.415246109513198 432 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_811 0416-0114 265 µM 0.21329387690264 0.400225525384859 no 1336 0.415548874598953 462 6612453 SGTC_2733 amorolfine 100 µM 0.213185486649802 0.400268734142758 no 1337 0.415591144025662 473 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3147 9097027 49.47 µM 0.21293445990642 0.400368808286686 no 1338 0.41568904178568 452 25236841 SGTC_568 1193-0097 7.48 µM 0.212830838567673 0.400410119804071 no 1339 0.415729454531923 431 3646150 SGTC_1997 st073024 93.8 µM 0.211458537087782 0.400957330722036 no 1340 0.416264741626987 475 686268 SGTC_1570 verbenone 133 µM 0.210179390981882 0.401467570610687 no 1341 0.416763831962962 462 29025 A natural terpanoid with antifungal properties. SGTC_481 bay k-8644 50 µM 0.208976836910381 0.401947411906387 no 1342 0.417233160431722 444 2303 A calcium channel antagonist. SGTC_2068 5226020 147 µM 0.208546913138843 0.402118995347269 no 1343 0.417400978189701 444 1810509 SGTC_3220 9131269 49.47 µM 0.208454647015163 0.402155821402355 no 1344 0.417436995592362 476 17722206 SGTC_1680 diphenhydramine 100 µM 0.206133117203726 0.403082695533248 no 1345 0.418343465219446 474 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2555 cholic acid 100 µM 0.204783894489813 0.403621625324846 no 1346 0.418870485343292 441 6708657 Influences liver metabolism. SGTC_2688 kanamycin b 96.69 µM 0.20463786177816 0.403679967223938 no 1347 0.418927535957544 459 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1026 k007-1105 30.6 µM 0.204310354835091 0.403810818144939 no 1348 0.419055489325806 415 7066794 SGTC_51 1013-0126 23.419 µM 0.204028052429387 0.403923616851024 no 1349 0.419165788648844 476 1627850 SGTC_677 0929-0063 136 µM 0.202714515335459 0.404448567772322 no 1350 0.419679088565694 461 1539583 SGTC_522 1273-0010 11.6 µM 0.202713548768604 0.404448954121159 no 1351 0.419679466328101 466 5705015 SGTC_218 alverine citrate 93.75 µM 0.202323443828455 0.404604891538736 no 1352 0.419831936711547 462 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2600 tangeritin 87.95 µM 0.201432744083668 0.404960989465222 no 1353 0.420180106910123 447 68077 A bioactive flavone. SGTC_2178 5812956 200 µM 0.200675435243031 0.405263820207402 no 1354 0.420476184403001 461 5403383 SGTC_1090 efavirenz 20.7 µM 0.200556072179323 0.405311555986909 no 1355 0.420522854700283 453 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2016 5121758 140 µM 0.200425270102653 0.405363868083882 no 1356 0.42057399887129 471 2795203 SGTC_36 0335-0881 14.2 µM 0.200179520339107 0.405462156151776 no 1357 0.420670091704466 446 23828853 SGTC_3078 9116413 49.47 µM 0.199809531489596 0.405610145112109 no 1358 0.420814773298525 463 17177322 SGTC_2560 caryophyllene 100 µM 0.19880926047895 0.406010303219836 no 1359 0.421205975889784 430 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_56 0957-0365 83.25 µM 0.198151817950498 0.406273366416926 no 1360 0.421463141824856 457 6752360 SGTC_812 4251-0442 148 µM 0.197283707899316 0.406620789048359 no 1361 0.421802764007912 473 5723007 SGTC_1477 0139-0234 16 µM 0.196691458454641 0.406857852881624 no 1362 0.422034497345621 449 620880 SGTC_2021 4019055 173 µM 0.196398886606912 0.406974975265351 no 1363 0.422148983824854 453 44827708 YER133W GLC7 SGTC_131 0141-0277 33.849 µM 0.195203130422685 0.407453746849752 no 1364 0.422616964239699 457 1547771 SGTC_1449 4112-4002 201 µM 0.195171994340559 0.407466215347942 no 1365 0.422629151360453 426 2059539 SGTC_2076 5212012 200 µM 0.19516894875845 0.407467434961623 no 1366 0.422630343450086 445 604802 SGTC_386 1509-0011 3.07 µM 0.193918817773116 0.407968129768723 no 1367 0.423119724464157 461 3107280 SGTC_1404 3909-7820 48.3 µM 0.19283645647058 0.408401751946579 no 1368 0.423543525584425 458 23741373 SGTC_1058 3448-5425 97.3 µM 0.192833165458349 0.408403070583274 no 1369 0.423544814323167 475 7279705 SGTC_23 0213-0011 39.996 µM 0.191720100469229 0.408849110805401 no 1370 0.423980730079738 445 627608 SGTC_1682 st012968 530 nM 0.191638821317185 0.408881686556143 no 1371 0.424012565531685 436 24207270 SGTC_963 1269-2853 151 µM 0.191028099237968 0.409126477069774 no 1372 0.424251789255942 418 3668223 SGTC_3023 9089636 49.47 µM 0.190578424912414 0.409306738849836 no 1373 0.424427947396241 453 17249241 SGTC_896 0964-0007 44.5 µM 0.19050712621367 0.409335322253795 no 1374 0.424455879767285 450 6756758 SGTC_1144 3486-0183 12.5 µM 0.190072520631199 0.409509564560697 no 1375 0.424626151444648 478 6744069 SGTC_271 rotenone 740 µM 0.18991947664803 0.409570927295429 no 1376 0.424686115036638 463 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1442 4112-3290 3 µM 0.188615182326912 0.410093971712355 no 1377 0.42519721631187 469 704353 SGTC_451 chloral hydrate 100 µM 0.187096894287859 0.410703032754689 no 1378 0.42579233158169 467 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1067 clotrimazole 1.36 µM 0.185872652628744 0.411194294058352 no 1379 0.426272314251484 448 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_487 nimodipine 119 µM 0.185831888723809 0.41121065411904 no 1380 0.426288298246984 474 4497 L-type voltage-gated calcium channels inhibitor SGTC_1480 1070-0044 41.2 µM 0.184008196184009 0.411942726866587 no 1381 0.427003512544523 448 3124987 SGTC_2292 7671323 168.05 µM 0.183963036951346 0.411960858736705 no 1382 0.427021226111836 469 937504 SGTC_2324 6149169 200 µM 0.183857679261592 0.412003161602212 no 1383 0.427062552907147 481 2888231 SGTC_3049 9092223 49.47 µM 0.183850050222228 0.412006224828168 no 1384 0.427065545446413 464 8623917 SGTC_2892 9047358 58.44 µM 0.18305875034102 0.412323978101438 no 1385 0.427375960627602 456 6466771 SGTC_2142 5622915 118.518 µM 0.182837758562973 0.412412729527437 no 1386 0.427462660458239 464 5322196 SGTC_47 0149-0135 24.25 µM 0.182833258090451 0.412414536986721 no 1387 0.427464426126879 488 5239155 SGTC_961 1252-1571 372 µM 0.182547362707823 0.412529360793993 no 1388 0.427576594327685 477 6813498 SGTC_3272 9137413 49.47 µM 0.182531858306865 0.412535588021375 no 1389 0.42758267749213 449 17614870 SGTC_1915 st067105 30.6 µM 0.18139893601944 0.412990677316885 no 1390 0.428027226979217 480 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2272 7805186 180 µM 0.180459415559109 0.413368166791998 no 1391 0.428395956490838 490 2956062 YPR165W RHO1 SGTC_1277 0873-0036 22 µM 0.180406648116614 0.413389370576203 no 1392 0.428416667756939 443 5965735 SGTC_164 4100-3994 89.624 µM 0.180294270266543 0.413434528726509 no 1393 0.428460776815761 498 4615967 SGTC_1163 k060-0048 49.9 µM 0.179968475243054 0.413565453350175 no 1394 0.428588658593805 435 6809982 SGTC_1727 st034309 9.9045 µM 0.178763021634352 0.414049962741988 no 1395 0.429061890987386 487 870305 SGTC_2287 7945887 168.79 µM 0.178608228089826 0.414112188589507 no 1396 0.429122666651516 465 1245853 SGTC_305 1682-2595 20.8 µM 0.178575870681245 0.414125196298343 no 1397 0.429135371159816 467 226033 SGTC_2372 9071633 200 µM 0.17831558522249 0.414229834724328 no 1398 0.429237569861313 478 21321366 SGTC_799 1310-0557 151 µM 0.178309447474931 0.414232302258931 no 1399 0.429239979848951 477 5354492 SGTC_2363 9053361 176 µM 0.178182355225302 0.414283397418792 no 1400 0.429289883235306 477 6469797 YMR079W SEC14 SGTC_2091 4-phenylthiadiazole 200 µM 0.174406672879185 0.415802000874114 no 1401 0.430772935245877 452 270010 SGTC_2330 7979373 200 µM 0.173907105518027 0.416003024785545 no 1402 0.430969234164379 441 1863007 SGTC_330 1488-0319 80.1 µM 0.173641057670414 0.416110090349654 no 1403 0.431073781393129 483 6846614 SGTC_1366 1683-0113 21.9 µM 0.173566419887254 0.416140127931397 no 1404 0.431103112223479 441 708623 SGTC_1263 0774-1208 64.8 µM 0.173478151317633 0.416175651783352 no 1405 0.4311378001112 481 906585 SGTC_2836 9010338 19.48 µM 0.173351357738628 0.416226681296106 no 1406 0.431187628532475 466 2994051 SGTC_1462 k081-0014 26.5 µM 0.172732394286829 0.416475810409582 no 1407 0.431430889773758 464 3270634 SGTC_1380 2291-0730 164 µM 0.172184844723547 0.416696223832128 no 1408 0.431646106048401 434 2999191 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.170380225393368 0.417422849649329 no 1409 0.43235556130604 457 5377381 SGTC_1666 st014829 29 µM 0.16990873608711 0.417612740310828 no 1410 0.4325409553092 455 3858230 SGTC_876 0720-0963 56.8 µM 0.167705515760068 0.41850033352388 no 1411 0.43340747835177 481 765861 SGTC_1009 4106-0057 9.87 µM 0.167557307641875 0.418560055858769 no 1412 0.433465779909418 485 2928005 SGTC_930 2810-3379 265 µM 0.166396888537647 0.419027726193394 no 1413 0.433922311204556 466 1015764 SGTC_3226 9131256 49.47 µM 0.165944982685286 0.419209883596992 no 1414 0.434100123582076 451 17178073 SGTC_3167 9103034 49.47 µM 0.165824314625376 0.419258526262201 no 1415 0.434147605362962 438 5127859 SGTC_1113 artemisinin 1.17947 µM 0.164545713167047 0.419774020703225 no 1416 0.434650781612302 477 2240 An anti-malaria and mitochondrial poison. SGTC_1631 benzylvanillin 81.9 µM 0.164343117398012 0.419855714008628 no 1417 0.434730520164921 440 75506 SGTC_1729 st035615 45.989 µM 0.163725776442554 0.420104667552839 no 1418 0.434973512348084 464 17385451 SGTC_3138 9097216 49.47 µM 0.162070430070323 0.420772372478181 no 1419 0.435625195847615 488 25237486 SGTC_3028 9087778 49.47 µM 0.161592220858756 0.420965306750543 no 1420 0.435813491827592 489 17217395 SGTC_1260 0700-1617 7.75 µM 0.16053537020977 0.421391762107873 no 1421 0.436229680762311 482 2853078 SGTC_3115 9123671 49.47 µM 0.160131187090252 0.421554880569252 no 1422 0.436388867206695 493 3286988 SGTC_2306 7482397 179.52 µM 0.159517445535215 0.421802597443143 no 1423 0.436630607375049 488 891448 SGTC_1945 st075991 56.6 µM 0.159062542198134 0.421986224395831 no 1424 0.4368097997157 418 1084980 SGTC_302 1094-0063 18.9 µM 0.158978163293761 0.422020286775005 no 1425 0.436843039090209 479 5440289 SGTC_719 2810-4230 27.3 µM 0.158417643711435 0.422246574129492 no 1426 0.437063855828917 493 721079 SGTC_544 k015-0020 52.4 µM 0.158225602573916 0.422324108962421 no 1427 0.437139514965255 474 3008304 SGTC_1664 st014217 9.02 µM 0.158103989838969 0.42237321053612 no 1428 0.437187428360093 486 3982782 SGTC_208 k072-0098 12.366 µM 0.157247829531335 0.422718922401402 no 1429 0.437524767314617 476 5948901 SGTC_1654 st012436 41.8 µM 0.156890938944735 0.422863050053202 no 1430 0.437665400548117 478 4323132 SGTC_2931 9014674 55.67 µM 0.156041674489149 0.423206060775267 no 1431 0.438000086024186 464 2996810 SGTC_1513 0337-0559 19 µM 0.153894048197904 0.424073728027878 no 1432 0.438846638525116 471 775073 SGTC_1143 3454-2408 5.08 µM 0.153554485802226 0.424210949198126 no 1433 0.438980513133571 477 X1143 SGTC_1234 0326-0494 15.5 µM 0.152945384458572 0.424457117249458 no 1434 0.439220672647563 491 1547813 SGTC_2073 5212005 126 µM 0.151935323425329 0.424865397900983 no 1435 0.439618973819082 495 691789 SGTC_2786 7743617 45.45 µM 0.15031901158147 0.4255189010571 no 1436 0.440256467167548 464 583674 SGTC_700 3453-2283 142 µM 0.146968588113847 0.426874185740724 no 1437 0.441578407050245 468 565664 SGTC_1317 1273-0028 910 nM 0.146803586732672 0.426940953136325 no 1438 0.441643526778517 480 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1072 oxiconazole 14.9 nM 0.145524607776324 0.427458559620216 no 1439 0.442148344176971 483 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2949 9072542 2.23 µM 0.143470671384976 0.428290054587919 no 1440 0.4429592362226 451 16457352 SGTC_172 1112-0046 2.638 µM 0.142093286983295 0.428847839675251 no 1441 0.443503160293275 469 2802135 YIL048W NEO1 SGTC_1174 0739-0097 51.1 µM 0.141321090793887 0.429160610214627 no 1442 0.443808144388319 488 728447 SGTC_2851 9015922 71.43 µM 0.140790987411652 0.429375349183843 no 1443 0.444017531573881 503 2996893 SGTC_2300 7976697 71.57 µM 0.140294310766602 0.429576566321276 no 1444 0.444213729610371 480 2236109 SGTC_1172 0370-0043 85 µM 0.140205159758828 0.429612685743217 no 1445 0.444248947638732 474 376585 SGTC_1138 3761-0006 1.03 µM 0.139846963182981 0.42975781458504 no 1446 0.444390453302492 489 12061087 SGTC_124 0136-0217 7.121 µM 0.139509519094129 0.429894543921956 no 1447 0.444523767174861 464 3976905 SGTC_1531 st059297 52.4 µM 0.137176304298696 0.430840170958214 no 1448 0.445445720132177 483 7566702 SGTC_1771 st048882 4.1505 µM 0.13656401563326 0.431088390938938 no 1449 0.445687710658503 460 4580403 SGTC_547 1120-0019 610 nM 0.136401156613163 0.431154418082303 no 1450 0.445752079689785 483 3676939 SGTC_1431 4049-0260 9.09 µM 0.136248023185689 0.431216503980948 no 1451 0.445812606044498 490 3854841 SGTC_2481 5478948 45.16 µM 0.1362459498174 0.431217344612037 no 1452 0.445813425556959 477 77792 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.134243309928846 0.432029444347752 no 1453 0.446605089732609 490 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2710 st078562 53.7235 µM 0.133629487965488 0.432278415806044 no 1454 0.446847782641821 496 17250908 SGTC_998 3996-0085 177 µM 0.133618212688211 0.432282989407163 no 1455 0.446852240847083 484 715391 SGTC_260 nsc-65238 3.989 µM 0.133088696751467 0.432497787654196 no 1456 0.447061617154238 457 3246252 SGTC_399 oxolinic acid 75 µM 0.130903303936061 0.433384503092867 no 1457 0.447925900506288 475 4628 A DNA gyrase inhibitor. SGTC_1686 st019653 115.5 µM 0.130476313909629 0.433557792103678 no 1458 0.448094796347699 503 97252 SGTC_1636 st007707 68.9 µM 0.129772832601554 0.433843319776192 no 1459 0.448373078782517 505 403051 SGTC_2532 xanthone 78.9 µM 0.129156098128808 0.434093667212587 no 1460 0.448617066895416 498 7020 An insecticide. SGTC_398 bronopol 33.3 µM 0.129110482380948 0.434112184798927 no 1461 0.448635113846727 497 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_914 3820-6779 408 µM 0.127481702461124 0.43477347793907 no 1462 0.449279577169347 489 2893481 SGTC_834 0312-0008 75.7 µM 0.12588043114401 0.435423780378279 no 1463 0.449913286563967 488 6385573 YIL048W NEO1 SGTC_1959 st077091 55.8 µM 0.124634736222592 0.43592979832792 no 1464 0.450406363636229 502 821356 YKL052C ASK1 SGTC_12 0849-0099 9.267 µM 0.124631312240988 0.435931189340014 no 1465 0.45040771903927 503 6071388 SGTC_645 0845-0943 5.41 µM 0.123622500304543 0.436341059398134 no 1466 0.450807088237345 480 1885106 SGTC_715 0868-0130 184 µM 0.123487012670526 0.436396111866642 no 1467 0.45086072898257 471 2876258 SGTC_1788 fluconazole 20 µM 0.122972207022285 0.436605303228829 no 1468 0.451064553239095 495 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1689 st020265 53.493 µM 0.121777278831065 0.437090930744643 no 1469 0.45153770443518 508 5758320 YPR016C TIF6 SGTC_129 0088-0017 176.636 µM 0.120267360621049 0.437704707995495 no 1470 0.452135679427998 499 182446 SGTC_2646 retinol 96.75 µM 0.119931019102385 0.437841450289401 no 1471 0.452268896061014 487 445354 A vitamin A analog and teratogen. SGTC_2446 5162541 200 µM 0.119372262167877 0.438068633724372 no 1472 0.452490217861458 476 1549321 SGTC_807 1315-0151 48 µM 0.118814297485957 0.438295515409537 no 1473 0.452711240584557 495 4011080 SGTC_1403 3909-7815 62.9 µM 0.118471791151188 0.438434796667032 no 1474 0.45284692253255 501 6615483 SGTC_318 1488-0629 67.2 µM 0.116973509990366 0.439044166738039 no 1475 0.453440522656459 481 3662576 SGTC_2921 7974240 10.71 µM 0.116761488103081 0.439130410449525 no 1476 0.453524531491304 483 2979074 YDR527W RBA50 SGTC_1349 flufenamic acid 69 µM 0.116687894885606 0.439160346488558 no 1477 0.453553691610867 478 3371 A non-steroidal anti-inflammatory. SGTC_808 0711-0032 135 µM 0.116494348547252 0.439239078376391 no 1478 0.453630382405161 511 4252555 SGTC_1722 st034304 3.6505 µM 0.112957273923939 0.440678330096082 no 1479 0.455032214407661 487 4036148 YLR033W RSC58 SGTC_369 0957-0393 4.5 µM 0.111083327845493 0.441441166189931 no 1480 0.455775134682514 484 6997992 SGTC_1375 2910-0797 186 µM 0.110287342274329 0.441765257714018 no 1481 0.456090747713608 515 742508 SGTC_545 4218-0007 221 µM 0.109942429046313 0.441905703854864 no 1482 0.456227516483693 488 2840508 SGTC_1514 1189-1591 158 µM 0.10985055364803 0.441943116076862 no 1483 0.456263948798113 515 767698 YMR146C TIF34 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.109330888515128 0.442154736624801 no 1484 0.456470023971495 485 16486 A toxic proline analog. SGTC_2760 etidronate 98.04 µM 0.108870378574082 0.442342281508584 no 1485 0.456652650716821 505 3305 A chelator and antioxidant. SGTC_2036 5160441 105 µM 0.106717432461468 0.443219249910295 no 1486 0.457506576240303 484 134534 YIL048W NEO1 SGTC_2253 7938677 135.83 µM 0.105249305196637 0.443817428038942 no 1487 0.458088994028213 483 2301972 SGTC_1155 4088-0394 48.2 µM 0.104314833962772 0.444198238537152 no 1488 0.458459753168344 505 2326248 SGTC_1134 3477-0009 42.5 µM 0.104167561801781 0.44425825877446 no 1489 0.458518187913401 509 3973534 SGTC_67 0335-0847 266 µM 0.104151025528503 0.444264998152764 no 1490 0.458524749242809 489 4552207 YOR254C SEC63 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.10389544440667 0.44436916259824 no 1491 0.458626161190234 495 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2144 5628481 200 µM 0.103738380388647 0.444433177395355 no 1492 0.458688483905508 502 2818399 SGTC_2519 cryptotanshinone 88.04 µM 0.103726659733113 0.444437954457136 no 1493 0.458693134680937 498 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.102440308709626 0.444962289588843 no 1494 0.45920359511044 490 66535 A nucleotide analog. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.10211440996404 0.445095145920246 no 1495 0.45933293165375 485 688761 SGTC_2833 9001315 45.46 µM 0.0995297744169731 0.4461490192091 no 1496 0.460358824347783 500 2989378 SGTC_1793 st048256 72.231 µM 0.0989779416673425 0.446374076029882 no 1497 0.460577892044752 512 672022 SGTC_2353 9059630 146.67 µM 0.0980655555291323 0.446746217074709 no 1498 0.460940119180761 489 4779114 SGTC_2789 5281112 71.43 µM 0.0970016204977035 0.447180230593347 no 1499 0.461362553774474 486 765948 SGTC_1494 4358-1428 177 µM 0.0964326720172702 0.447412349078028 no 1500 0.461588472256729 513 1564571 SGTC_49 0717-0965 32.132 µM 0.0964007332596723 0.447425379924379 no 1501 0.461601154890277 508 5889349 YGL099W LSG1 SGTC_1017 4239-0030 168 µM 0.0962688487416099 0.447479188720024 no 1502 0.461653525625468 507 1149593 SGTC_1719 st032227 49.2 µM 0.096268422370765 0.447479362680613 no 1503 0.461653694936447 508 3125804 SGTC_95 0471-0001 561.058 µM 0.0950097683462445 0.447992941209191 no 1504 0.462153534001931 506 4015405 SGTC_2744 captopril 92.04 µM 0.0939197136332112 0.448437795316619 no 1505 0.462586466920484 508 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1558 st069300 45.6 µM 0.0928578837145609 0.448871193165669 no 1506 0.463008232526361 509 24208000 SGTC_862 0452-0056 10.2 µM 0.0925954173996683 0.448978331175553 no 1507 0.46311249224677 515 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2694 st077685 81.9 µM 0.0901999708510347 0.449956316665091 no 1508 0.464064153745776 480 2838096 SGTC_2922 7999257 32.47 µM 0.0895502845055016 0.450221615823798 no 1509 0.464322296406632 517 2988377 SGTC_2893 9048488 25.97 µM 0.089271861147032 0.450335316707112 no 1510 0.46443292815693 510 6467338 SGTC_1810 st050138 53 µM 0.0892178334500142 0.450357380690813 no 1511 0.464454396425578 521 3444541 SGTC_1425 4048-4433 7.33 µM 0.0888262541091801 0.450517299551071 no 1512 0.46460999619841 523 23734946 SGTC_1681 tripelennamine 100 µM 0.0887900074109807 0.450532102910937 no 1513 0.464624399627618 493 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2405 ticlatone 3.52 µM 0.0883739639870931 0.450702022359487 no 1514 0.46478972702173 426 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_235 0330-0087 5 mM 0.0879951127852143 0.450856759711678 no 1515 0.464940280254125 500 46494818 YHR062C RPP1 SGTC_734 2023-0417 80 µM 0.0836095948882738 0.452648511003303 no 1516 0.466683419016682 519 3935732 SGTC_1962 st076595 64.5 µM 0.0827629930022636 0.452994511674429 no 1517 0.467019997721165 499 279619 SGTC_772 k072-0172 35.3 µM 0.0825776351823124 0.453070270978647 no 1518 0.467093692532474 497 5861980 SGTC_2345 9052315 157.45 µM 0.0805989196138273 0.453879115967934 no 1519 0.467880462717354 497 6469265 SGTC_1765 st044815 90.4 µM 0.0789343381618965 0.454559699812783 no 1520 0.468542425268538 517 645695 SGTC_2278 7948257 134.34 µM 0.0785650154951011 0.454710719915463 no 1521 0.468689307541697 514 1247028 SGTC_1855 st056195 39.6 µM 0.0761937869071437 0.455680496395681 no 1522 0.469632462825818 518 4028379 SGTC_1032 k061-1018 98.7 µM 0.0761126543836038 0.455713682387308 no 1523 0.469664736301961 495 4005393 SGTC_1131 3454-3128 32.3 µM 0.0748216826498728 0.456241775633695 no 1524 0.470178294955925 512 710982 SGTC_1141 3253-0389 52.6 µM 0.073693844343347 0.456703199768459 no 1525 0.470626998487159 516 5402031 SGTC_2522 biochanin a 4.94 µM 0.0736077742221848 0.45673841540548 no 1526 0.470661242494183 511 5280373 A possible chelator. SGTC_1838 st055369 84.5 µM 0.0721026605641981 0.457354288155756 no 1527 0.47126010445738 496 676036 SGTC_3072 9116419 49.47 µM 0.0719246655906267 0.457427128163823 no 1528 0.471330930289398 498 17170162 SGTC_913 3487-1245 167 µM 0.0708182669786054 0.457879926207066 no 1529 0.471771196689643 519 4016153 SGTC_2841 9004761 38.96 µM 0.0708129521430134 0.457882101457137 no 1530 0.471773311692409 512 2991039 SGTC_1248 0469-0687 58.6 µM 0.0695665083446975 0.458392279306852 no 1531 0.472269347401177 507 4017482 SGTC_879 0831-1030 162 µM 0.0688941201667172 0.458667520838375 no 1532 0.472536949413842 522 1549252 SGTC_81 0411-0046 9.971 µM 0.0686580999452029 0.458764140222037 no 1533 0.47263088543021 517 12925265 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0684978954488807 0.458829724379489 no 1534 0.472694647665773 503 688664 SGTC_1911 st060208 74.3 µM 0.067566555482944 0.459211016383802 no 1535 0.473065339696386 496 688783 SGTC_2451 5856223 45.7 µM 0.0673363562879295 0.459305266082994 no 1536 0.473156967211923 515 2179896 SGTC_1259 0671-0132 43 µM 0.0669666273809619 0.459456647757875 no 1537 0.47330413551532 498 X1259 SGTC_881 0833-0569 170 µM 0.0667068752891675 0.459563004080821 no 1538 0.473407530408449 506 5418700 SGTC_505 gw-5074 63.9 µM 0.0652921249824304 0.460142328716299 no 1539 0.473970706160251 513 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3120 9124077 49.47 µM 0.0642842182131182 0.460555107105514 no 1540 0.474371959751536 516 18774327 YGL155W CDC43 SGTC_2202 7226349 200 µM 0.0624406511558953 0.46131023168922 no 1541 0.475105961579224 507 844334 SGTC_53 0973-0023 39.979 µM 0.0613262302000247 0.461766766052382 no 1542 0.475549700716913 515 674768 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0603462457173428 0.462168268741121 no 1543 0.475939935138892 518 688801 SGTC_1882 5615643 20 µM 0.0599442270186488 0.462332988226739 no 1544 0.476100027569072 518 2253075 SGTC_2806 7952793 58.44 µM 0.0576190829293013 0.463285797470979 no 1545 0.477026024472717 517 2972490 SGTC_840 0245-0196 390 µM 0.056447886313722 0.46376581643391 no 1546 0.477492504989217 530 3827528 SGTC_1885 st057546 99.9 µM 0.056408975524398 0.463781765064094 no 1547 0.477508003453732 486 702008 SGTC_1941 st076221 61.8 µM 0.0562332862842168 0.463853776733645 no 1548 0.477577982242898 500 2828568 SGTC_521 r062-0005 13.8 µM 0.0556920851232829 0.464075612202483 no 1549 0.477793552437376 523 2832033 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0550312144409371 0.46434651470921 no 1550 0.478056797968166 524 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_508 roscovitine 141 µM 0.0549105597311437 0.464395974983133 no 1551 0.478104859562093 527 160355 A CDKinase inhibitor. SGTC_1621 st003705 32.4 µM 0.053927304973647 0.464799063402479 no 1552 0.478496541045189 507 24207032 SGTC_2870 9038528 12.99 µM 0.0533049065160897 0.465054236330449 no 1553 0.478744485463652 515 6463316 SGTC_589 1227-0070 34.1 µM 0.0525370956479979 0.465369045696378 no 1554 0.479050369041019 530 2841384 SGTC_667 1498-1044 59 µM 0.0522023070772122 0.465506318820794 no 1555 0.479183747330127 527 6739982 SGTC_789 1309-1135 70.6 µM 0.0503280317846628 0.466274901965857 no 1556 0.4799304929676 525 3092424 SGTC_3320 9137005 35.139 µM 0.0499849250743366 0.466415613271269 no 1557 0.480067200676277 531 4908713 SGTC_3053 9095903 49.47 µM 0.0495802811979273 0.466581566943812 no 1558 0.480228430313832 531 17174018 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0495686344655463 0.466586343620265 no 1559 0.480233070981787 531 6708630 An antioxidant. SGTC_3346 9158254 43.5805 µM 0.048584057144402 0.466990165826128 no 1560 0.480625387758037 525 17639500 SGTC_2598 perillyl alcohol 100 µM 0.048232280271559 0.467134454591493 no 1561 0.480765562090088 525 10819 An apoptosis inducer. SGTC_1501 4491-0275 38.4 µM 0.0479538770105563 0.467248650672069 no 1562 0.480876500550097 530 5104718 SGTC_2984 9022109 38.96 µM 0.0471405425483038 0.4675822814522 no 1563 0.481200607478846 522 6459207 SGTC_2468 5987765 72.9 µM 0.0470498023568241 0.467619504604912 no 1564 0.481236767454898 504 26772094 SGTC_1633 st005664 67.9 µM 0.0465682829466699 0.467817036695745 no 1565 0.481428655567671 518 2063822 SGTC_2478 5763493 32.33 µM 0.0460800273342393 0.468017340247831 no 1566 0.481623232487172 525 1365576 YLR208W SEC13 SGTC_1629 st005085 44.9 µM 0.0456019700101637 0.468213467867276 no 1567 0.481813749483253 530 24207091 SGTC_2766 oltipraz 83.91 µM 0.0438093389236443 0.468948980350809 no 1568 0.482528191424184 522 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_231 b-estradiol 524 µM 0.0432637977345458 0.469172835818156 no 1569 0.482745624704762 530 450 A steroid. SGTC_1724 st037281 8.293 µM 0.0421889621622718 0.469613908543472 no 1570 0.483174030822889 530 574124 YDL195W SEC31 SGTC_1903 st060211 78.3 µM 0.0393081038393398 0.47079628857004 no 1571 0.484322372840913 520 688960 SGTC_3326 9140064 16.379 µM 0.0393078753232809 0.470796382369392 no 1572 0.484322463935228 528 1868434 SGTC_1979 st071809 45.3 µM 0.0389967339494193 0.470924098567088 no 1573 0.484446496282727 523 4976333 SGTC_2424 5537928 59.2 µM 0.0367225255067632 0.471857697489568 no 1574 0.485353123998694 533 5382802 SGTC_2692 st077426 47.7 µM 0.0357018507027018 0.472276751401179 no 1575 0.485760047423502 534 25238571 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0354535562436131 0.472378697210783 no 1576 0.48585903991013 527 688751 SGTC_592 k241-0073 46.5 µM 0.0349850455218069 0.472571065286226 no 1577 0.486045832759394 533 4230158 SGTC_2807 7945238 51.95 µM 0.0344135444412925 0.472805729327176 no 1578 0.486273691483677 530 17148797 SGTC_1227 3909-8010 46.6 µM 0.0341376698815073 0.472919009554463 no 1579 0.486383684879264 533 15982272 SGTC_2387 9077560 195.08 µM 0.0337884458963127 0.473062411826519 no 1580 0.486522924762561 527 5303272 SGTC_2593 nobiletin 86.24 µM 0.0332246450932321 0.47329393339973 no 1581 0.486747722513299 526 72344 An anti-infammatory. SGTC_673 1082-0474 110 µM 0.0329822831395 0.473393460726221 no 1582 0.486844357980586 537 3098046 SGTC_1461 k072-0203 53.8 µM 0.0301862707949811 0.474541777767745 no 1583 0.487959248930692 526 5418714 SGTC_2062 5245942 200 µM 0.0293610770164683 0.474880724165915 no 1584 0.488288307726157 534 1376160 SGTC_728 3030-5151 22.5 µM 0.0290353338799573 0.475014527409537 no 1585 0.488418205052463 535 3125388 SGTC_1752 st044819 83.042 µM 0.0285462745649731 0.475215420191213 no 1586 0.488613230642768 528 441209 YML126C ERG13 SGTC_553 k007-0256 45.7 µM 0.0275457782271896 0.475626417507581 no 1587 0.489012213969729 521 6287000 SGTC_2426 5582046 32.21 µM 0.0265817968177945 0.476022439268985 no 1588 0.489396646082415 533 2251934 SGTC_1028 k015-0029 4.8 µM 0.0259313673058057 0.476289661398165 no 1589 0.489656040480885 541 4588309 SGTC_1952 st077036 64.1 µM 0.025556935983627 0.476443497415679 no 1590 0.489805367473258 515 2937007 SGTC_22 0964-0034 14.468 µM 0.0241306702833859 0.477029514102527 no 1591 0.490374189546251 535 138402 SGTC_1841 st054148 70 µM 0.021850645519129 0.47796642156617 no 1592 0.491283547266631 536 675442 SGTC_987 1497-1013 404 µM 0.0206305599193713 0.478467829324674 no 1593 0.491770181179866 541 1676435 SGTC_2381 9035592 200 µM 0.0197513402132899 0.478829175624928 no 1594 0.492120867592857 525 4749657 SGTC_810 3825-7150 143 µM 0.01939617330148 0.478975148926071 no 1595 0.49226253154924 533 22330411 YGL099W LSG1 SGTC_1325 1431-0015 227 µM 0.0193501684701065 0.478994057079678 no 1596 0.492280881377726 519 1103340 SGTC_246 cycloheximide 667 µM 0.0182645145860225 0.479440278416957 no 1597 0.492713917999922 540 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3168 9103419 49.47 µM 0.0179017961984486 0.479589367321894 no 1598 0.492858598042654 547 16649256 SGTC_1849 st056239 19.2 µM 0.0173272019819363 0.479825549832812 no 1599 0.49308779240765 540 5393181 SGTC_446 go6976 132 µM 0.0160753978705306 0.480340118648467 no 1600 0.493587120317395 539 3501 A protein kinase C inhibitor. SGTC_1082 camptothecin 424.86 nM 0.0159655060541589 0.480385292549919 no 1601 0.493630955183617 544 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2718 lomofungin 53.02 µM 0.0158551434398094 0.480430660238704 no 1602 0.493674977924358 532 5351222 A RNA synthesis inhibitor. SGTC_1098 clofazimine 15.1 µM 0.0158453720202697 0.480434677070602 no 1603 0.493678875667105 545 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1044 1222-0021 1.78 µM 0.0157792695818315 0.480461850491195 no 1604 0.493705243428066 539 4306703 SGTC_1214 0358-0031 63.7 µM 0.0152518984029208 0.480678645717484 no 1605 0.493915608763861 535 4301366 SGTC_3146 9095609 49.47 µM 0.0145163877183773 0.480981013835225 no 1606 0.494209002566304 537 17173999 SGTC_764 1951-2361 146 µM 0.014207162593812 0.481108139424736 no 1607 0.49433235282036 535 5438930 SGTC_1511 0906-3109 28.5 µM 0.0133993315092091 0.481440256021548 no 1608 0.494654600086381 540 2882180 SGTC_2678 equilin 100 µM 0.0120070278094528 0.482012691885488 no 1609 0.495210004039725 542 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_640 3381-0960 37.1 µM 0.0104723831757392 0.482643693143436 no 1610 0.495822199938558 543 1745025 SGTC_97 0535-0701 19.132 µM 0.00985993947001266 0.482895524416435 no 1611 0.496066516997808 539 2832013 YGL099W LSG1 SGTC_2888 9058547 12.99 µM 0.00926867813741522 0.483138652165918 no 1612 0.496302385350318 542 16476514 SGTC_2467 5474540 200 µM 0.00858435009628162 0.483420056939627 no 1613 0.496575381857504 540 5413519 SGTC_708 3448-5400 146 µM 0.00791838850914947 0.483693917114566 no 1614 0.496841053042547 545 3462195 SGTC_2539 epi(13)torulosol 80 µM 0.00788079013418152 0.483709378743786 no 1615 0.496856052155989 543 6708597 SGTC_114 0364-0001 490.298 µM 0.00623891256723163 0.484384593786593 no 1616 0.497511050139874 544 4003655 SGTC_1930 st074634 34.3 µM 0.00557263767948761 0.484658609332709 no 1617 0.497776850722688 542 684253 YOR116C RPO31 SGTC_2924 9010168 62.78 µM 0.00554226555701103 0.484671100497498 no 1618 0.497788967259376 543 2993929 SGTC_2125 5246583 200 µM 0.00415951903058928 0.485239799401342 no 1619 0.49834059677762 546 835267 SGTC_322 k048-0136 19.3 µM 0.00286771287670985 0.485771123306364 no 1620 0.498855949653498 545 6823282 SGTC_118 0083-0097 135.343 µM 0.00175625977031987 0.486228287692277 no 1621 0.499299354082436 547 5207356 SGTC_651 3253-0966 34.4 µM 0.00123812105199986 0.486441415428653 no 1622 0.499506061290299 546 781462 SGTC_3248 9135562 49.47 µM 0.000672951984572706 0.486673892730082 no 1623 0.499731531020937 547 17650701 SGTC_48 0382-0018 55 µM -0.000129383022358135 0.487003933904 no 1624 0.499948383642159 549 762596 SGTC_1226 3909-7979 35.4 µM -0.00124994737184567 0.487464893830273 no 1625 0.499501343274942 548 6615510 SGTC_538 2922-0838 53.3 µM -0.00262882827881036 0.488032138828271 no 1626 0.498951250459607 553 777039 SGTC_2966 9084041 48.03 µM -0.00286407108104722 0.488128915627099 no 1627 0.498857402513798 556 17741380 SGTC_1136 pergolide 1.05886 µM -0.00359084398644886 0.488427907933925 no 1628 0.49856746359004 550 47811 A dopamine receptor agonist. SGTC_2416 tofa 880 nM -0.00528658931463886 0.489125557741072 no 1629 0.497890965827167 553 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_730 1436-0052 41.2 µM -0.0053941674434701 0.489169817808297 no 1630 0.497848048975142 550 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_773 4358-1457 44.6 µM -0.00555186477762151 0.48923469828727 no 1631 0.497785137783332 550 1186886 SGTC_1999 st074831 12.5 µM -0.00569346010776915 0.489292954257002 no 1632 0.49772865031239 552 17112523 SGTC_2225 6654152 15.4 µM -0.00604470592155088 0.489437466824827 no 1633 0.497588525920571 551 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2581 avocatin a 64 µM -0.00673187707203061 0.489720192670861 no 1634 0.497314389894006 558 6710728 A skin care supplement. SGTC_2441 5730946 39.09 µM -0.00736448434766121 0.489980473631795 no 1635 0.497062022377565 553 1774275 SGTC_539 4859-0462 2.54 µM -0.00762770239054995 0.490088773752575 no 1636 0.496957016521851 555 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_624 k048-0052 28 µM -0.0090588152473226 0.49067761259071 no 1637 0.496386105014888 555 6835531 SGTC_748 act1.228 77.9 µM -0.00915183398801689 0.490715886353063 no 1638 0.496348997444638 553 4421505 YNR035C ARC35 SGTC_389 tpck 16.7 µM -0.0103147057155361 0.491194372046104 no 1639 0.495885100746489 557 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1013 4112-3890 241 µM -0.0103171935764617 0.491195395737636 no 1640 0.495884108286387 551 705171 SGTC_116 0155-0182 31.788 µM -0.0108392779907334 0.491410221476004 no 1641 0.495675838394891 555 771486 SGTC_2174 5790901 200 µM -0.0115698820475627 0.491710852424333 no 1642 0.495384387848176 556 786020 SGTC_66 0109-0187 42.4 µM -0.0122579583203811 0.491993988232655 no 1643 0.495109904617194 556 759417 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0124581121539847 0.492076350094518 no 1644 0.495030060887659 556 65057 A dermal irritant. YDR527W RBA50 SGTC_1679 SEC14.276 6.7 µM -0.013483660379923 0.492498361031875 no 1645 0.494620960773413 565 1005053 YMR079W SEC14 SGTC_2388 9080168 200 µM -0.0138482176926264 0.492648377646376 no 1646 0.494475537028701 553 15943073 SGTC_327 1273-0057 3.96 µM -0.0148959418399848 0.493079525527133 no 1647 0.494057598753436 556 3108138 SGTC_2882 9058044 58.44 µM -0.0154645676587089 0.493313523566648 no 1648 0.493830776011712 562 18076804 SGTC_325 2810-4341 181 µM -0.0159367239605987 0.493507824707261 no 1649 0.49364243611697 555 774970 SGTC_1545 lovastatin 49.4 µM -0.0160736801614364 0.493564185033205 no 1650 0.493587805495651 557 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_286 k060-0067 22.9 µM -0.016216782832616 0.4936230748968 no 1651 0.493530723229987 560 5985051 SGTC_2872 9044037 25.97 µM -0.0163112316295807 0.493661942708494 no 1652 0.493493048594696 554 6465195 SGTC_2102 5377816 72.7585 µM -0.0164015603386546 0.493699115067325 no 1653 0.493457017473581 556 1379702 SGTC_2815 7968870 71.43 µM -0.0165136958599089 0.493745261511231 no 1654 0.493412287931028 563 2977326 YHR190W ERG9 SGTC_137 0438-0332 85.389 µM -0.0174818345551943 0.494143677111416 no 1655 0.493026112279007 559 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3300 9124615 50.48 µM -0.0175399834302482 0.494167607156722 no 1656 0.493002917790551 561 24824903 SGTC_256 clotrimazole 625 nM -0.0176898585239133 0.494229285450459 no 1657 0.492943135554463 556 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1290 0986-0249 10.2 µM -0.0187478601716396 0.49466469009481 no 1658 0.492521124028418 555 53329 SGTC_3174 9107204 49.47 µM -0.0194242050718115 0.494943033015542 no 1659 0.492251350597301 559 3938802 SGTC_1445 4239-0156 97.7 µM -0.0198774149017864 0.49512954833504 no 1660 0.49207058094164 575 4008346 SGTC_666 0272-0154 136 µM -0.0199609386432369 0.495163922061068 no 1661 0.492037266399589 560 6870312 SGTC_756 0508-1999 28.3 µM -0.0200606276966437 0.495204948577293 no 1662 0.491997504183126 559 6753853 SGTC_776 4476-4378 112 µM -0.0204670196086354 0.495372197594691 no 1663 0.491835410551201 561 2892008 SGTC_2942 9052777 62.25 µM -0.020818352145524 0.495516787796175 no 1664 0.491695279008117 559 6469503 SGTC_3289 9119912 71.43 µM -0.0208326105246924 0.495522655816112 no 1665 0.491689591971187 564 17014829 SGTC_2196 6573537 42.6665 µM -0.0225915596735051 0.496246556397371 no 1666 0.490988038257902 562 2903087 SGTC_1815 st051655 58.2 µM -0.0227339983607041 0.496305178021685 no 1667 0.490931228034045 562 5984156 SGTC_3336 9143619 71.43 µM -0.0230719741810661 0.496444274618973 no 1668 0.49079643054862 562 45595730 SGTC_2962 9082311 13.18 µM -0.0232535925455331 0.496519021259691 no 1669 0.490723994738276 560 16459453 SGTC_1311 1190-0148 100 µM -0.0234630705499283 0.496605233932683 no 1670 0.490640447900834 556 1961333 SGTC_2260 7964312 200 µM -0.0242627340049001 0.496934344486539 no 1671 0.490321519165065 577 231951 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.02502382770617 0.497247583162586 no 1672 0.49001797889828 567 4174840 SGTC_276 colchicine 750 µM -0.0266699553090346 0.497925075372365 no 1673 0.4893614883974 564 2833 A microtubule depolymerizer. SGTC_1900 st060200 72.8 µM -0.0273701772477511 0.498213265717309 no 1674 0.489082242221272 556 688945 SGTC_2644 guaiazulene 100 µM -0.0285346318476358 0.498692522290672 no 1675 0.488617873523641 568 3515 A coloring agent. SGTC_731 3966-0296 387 µM -0.0292440494367444 0.498984499471551 no 1676 0.488334974936182 563 660956 SGTC_831 k061-1017 217 µM -0.0313575519836682 0.49985436283322 no 1677 0.487492196549735 571 1240153 SGTC_2313 7726885 200 µM -0.0315201682038564 0.499921291573955 no 1678 0.487427354117207 564 726423 SGTC_1056 3448-1962 115 µM -0.0319026426434464 0.499921291573955 no 1679 0.487274845594586 569 715507 SGTC_3318 9139014 38.6185 µM -0.0321753939261984 0.499809034017437 no 1680 0.487166089409568 562 16643984 SGTC_1152 3909-8331 15.9 µM -0.033073440525398 0.499439420816678 no 1681 0.486808011274814 564 16001939 SGTC_1982 st072467 71.9 µM -0.0332119347481915 0.499382420142427 no 1682 0.486752790410465 576 3163533 SGTC_1096 rimcazole 32.2 µM -0.0332993760870405 0.499346431533789 no 1683 0.48671792564783 581 18528119 A dopamine reuptake inhibitor. SGTC_1827 berberine 7.24 µM -0.0341646205354378 0.498990319481102 no 1684 0.486372939391989 561 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2874 9043904 71.43 µM -0.0349214507824703 0.49867882853658 no 1685 0.486071187896431 572 4463428 SGTC_1333 1482-0047 286 µM -0.035527283532516 0.498429484666038 no 1686 0.485829645495365 563 3811116 SGTC_420 mitomycin C 81.9 mM -0.0357586692440127 0.498334252914355 no 1687 0.485737394569581 561 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3043 9092303 49.47 µM -0.0364457518646423 0.498051469907604 no 1688 0.485463466840186 570 25236084 SGTC_2137 5261020 140 µM -0.0372218008133123 0.497732072160572 no 1689 0.48515407805993 568 763655 SGTC_2699 st077704 54.6 µM -0.0373657782314961 0.497672815661679 no 1690 0.485096679310183 573 645852 SGTC_3099 9120367 49.47 µM -0.0376338847833589 0.497562471720592 no 1691 0.484989795449778 557 24824940 SGTC_1613 st002381 52.1 µM -0.0379150410317905 0.497446757149085 no 1692 0.484877710331473 561 551167 SGTC_971 1315-0384 26.7 µM -0.0381946405002878 0.497331683509494 no 1693 0.484766247020463 579 6769120 SGTC_989 1501-0895 10.3 µM -0.0384931042609273 0.49720884621355 no 1694 0.4846472647068 561 2830112 SGTC_3003 9075612 71.4286 µM -0.0388876325528818 0.497046472508026 no 1695 0.48448998845233 577 6501993 SGTC_210 3551-0445 56.827 µM -0.0391007763172716 0.496958750375293 no 1696 0.484405021016166 565 2865180 YOR207C RET1 SGTC_1518 st038567 90.8 µM -0.0398555395221728 0.496648118816019 no 1697 0.484104148619121 566 77966 SGTC_1426 4048-4480 71.7 µM -0.0404870714789286 0.496388206061301 no 1698 0.48385240702825 576 14224343 SGTC_2570 licareol 100 µM -0.0415799764896473 0.495938414690909 no 1699 0.483416767940774 588 443158 SGTC_120 rhodamine 6G 52.259 µM -0.0418565297909402 0.495824598378235 no 1700 0.483306535103517 562 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2338 7999974 200 µM -0.0436059322494754 0.495104634982211 no 1701 0.482609261473108 577 315925 SGTC_2804 7954240 19.48 µM -0.0445624939192938 0.49471097036205 no 1702 0.482228019230262 575 828705 SGTC_1124 fisetin 1.16336 µM -0.0452401649685836 0.494432083841052 no 1703 0.481957939996271 596 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3186 9110464 49.47 µM -0.0460081933014636 0.494116015277024 no 1704 0.481651859758155 560 17018021 SGTC_2803 7707263 71.43 µM -0.0463809525566639 0.493962614075121 no 1705 0.481503308915477 575 2199229 SGTC_3254 9136651 49.47 µM -0.046910773405301 0.493744579032061 no 1706 0.481292170806383 569 16454030 SGTC_462 ag-879 158 µM -0.0470011166837235 0.493707400610725 no 1707 0.481256168764513 568 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_315 k915-0449 187 µM -0.0473133851638145 0.493578895080382 no 1708 0.481131730106163 579 20970215 YNL149C PGA2 SGTC_670 4204-0025 119 µM -0.0474957266395599 0.49350385775328 no 1709 0.481059068070771 560 719039 SGTC_1089 terbinafine 2.25 µM -0.0481152085118735 0.493248929752254 no 1710 0.480812212802044 573 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3173 9105693 49.47 µM -0.0481990052215003 0.493214446099202 no 1711 0.480778821493091 582 17096658 SGTC_87 0100-0052 35.5 µM -0.0485539974061555 0.493068361843643 no 1712 0.480637365722514 564 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2389 9091542 195.52 µM -0.048682500102551 0.493015481412565 no 1713 0.480586161116624 566 3626624 YOL127W RPL25 SGTC_532 1548-0774 215 µM -0.0490476779213988 0.49286520694734 no 1714 0.480440650074783 602 5932993 SGTC_1490 4089-0339 670 nM -0.0496460377825799 0.492618977848495 no 1715 0.480202229498059 564 742542 SGTC_456 gingerol 170 µM -0.049702532538413 0.492595730021136 no 1716 0.480179719141021 586 442793 A herb. SGTC_806 3966-4455 5.86 µM -0.0504825216064054 0.492274763875535 no 1717 0.479868938690791 602 714982 SGTC_2472 5377652 49.4 µM -0.0508929550256446 0.492105872179797 no 1718 0.47970540965593 599 1610903 SGTC_34 0469-0683 81.75 µM -0.05170058377359 0.491773540369814 no 1719 0.479383636039738 569 3690923 SGTC_316 k060-0003 58.6 µM -0.0517249818103905 0.491763500889516 no 1720 0.479373915637201 587 6152314 SGTC_457 grayanotoxin iii 135 µM -0.052325120080186 0.491516553320563 no 1721 0.479134818900241 572 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1974 st069448 26.9 µM -0.0530015924096574 0.491238199375655 no 1722 0.478865319469646 566 6323587 YNR016C ACC1 SGTC_939 1165-0479 45.3 µM -0.0530066681902654 0.49123611081608 no 1723 0.478863297368635 579 1377347 SGTC_11 0438-0307 1.3 µM -0.0533462919128927 0.491096364509658 no 1724 0.478727998537023 576 4011476 SGTC_1153 4055-0057 267 µM -0.053497428806699 0.491034175969004 no 1725 0.478667789616313 569 882706 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0535984078120965 0.490992626096682 no 1726 0.478627562536161 577 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1897 st060201 15 µM -0.0540788801065583 0.490794927313383 no 1727 0.478436159426779 575 611878 SGTC_1715 st032160 10.2275 µM -0.0542589056534633 0.490720853212892 no 1728 0.478364444916713 568 5289825 SGTC_209 4077-0173 175.592 µM -0.0550569812695353 0.490392477411476 no 1729 0.478046534051668 561 15993494 SGTC_1851 st056236 18.9 µM -0.0564875392709619 0.489803877162622 no 1730 0.477476710948575 577 5393171 SGTC_387 norethindrone acetate 66.7 µM -0.0573781164967501 0.489437462064165 no 1731 0.477121997391884 589 541197 SGTC_1296 1068-0102 11.9 µM -0.0575850247385502 0.489352333930189 no 1732 0.47703958920246 584 767053 SGTC_40 0327-0103 19.753 µM -0.0587235488134505 0.488883920433821 no 1733 0.476586151230525 582 409036 SGTC_2778 tioconazole 65.09 nM -0.0596910635581883 0.488485875909921 no 1734 0.476200844646243 590 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0603363468187939 0.488220406752695 no 1735 0.475943877045134 582 442882 SGTC_1642 st009582 77.7 µM -0.0609725708094002 0.487958669682876 no 1736 0.475690526861656 581 6739311 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0610510744853874 0.487926374303896 no 1737 0.475659266662471 626 61125 An anti-inflammatory. SGTC_1239 0337-0584 35.4 µM -0.0614648043936677 0.487756172578509 no 1738 0.475494521706347 585 914301 YML130C ERO1 SGTC_445 e6 berbamine 66 µM -0.0615868629341836 0.487705960113535 no 1739 0.475445919471128 579 6610268 A calcium/calmodulin antagonist. SGTC_1932 st074806 40.9 µM -0.0626715658091574 0.487259743497299 no 1740 0.475014020033083 570 17251235 SGTC_2476 5806916 10.51 µM -0.0631999361525098 0.487042392364749 no 1741 0.474803647811273 580 2870194 SGTC_2284 7945075 39.21 µM -0.0634126445887453 0.486954893420323 no 1742 0.474718959295468 587 1245402 SGTC_873 0591-4978 488 µM -0.0634610539125611 0.486934980030039 no 1743 0.474699685589427 571 3305145 SGTC_1895 st058434 18.3 µM -0.0636007156923356 0.486877529719579 no 1744 0.474644080928893 619 5393175 SGTC_3001 9076041 71.4286 µM -0.0638783307827944 0.486763332692609 no 1745 0.474533553282001 584 16004211 SGTC_2730 imipramine 71.33 µM -0.0642123136749926 0.486625950197474 no 1746 0.474400586367887 586 3696 A tricyclic antidepressant. SGTC_1798 st045719 60.953 µM -0.0646580143852028 0.486442615510532 no 1747 0.47422314625021 569 3980186 SGTC_293 4049-0273 38.5 µM -0.065227592740426 0.486208329125294 no 1748 0.47399639603709 572 1380311 SGTC_660 4031-1742 102 µM -0.0656599588395034 0.486030485845727 no 1749 0.473824275901442 569 6738706 SGTC_2702 st077768 96.8 µM -0.0656943524726999 0.486016338980006 no 1750 0.473810584387945 574 6484119 SGTC_1156 4092-0367 4.88 µM -0.0670860784964953 0.485443906095938 no 1751 0.473256588338571 574 1357585 SGTC_2508 celastrol 40.54 µM -0.0672437847163051 0.48537904158803 no 1752 0.47319381441009 574 122724 Celastrol is a natural product and antioxidant. SGTC_132 0417-1715 25.805 µM -0.0674999917778363 0.485273664547109 no 1753 0.473091834286241 582 6769098 SGTC_2340 7987427 183.45 µM -0.0676112718198258 0.485227895786846 no 1754 0.473047541159629 573 2239331 SGTC_2333 9017922 200 µM -0.0684519583697487 0.48488213318688 no 1755 0.472712930995011 579 3163164 SGTC_395 anisomycin 6.25 µM -0.0709196281629438 0.483867281789745 no 1756 0.47173086084645 602 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2123 5259487 200 µM -0.0715079930866277 0.483625326605379 no 1757 0.471496731641018 579 2173474 SGTC_347 4534-1311 26.2 µM -0.0716404735927341 0.483570847052795 no 1758 0.471444014769788 574 2862016 SGTC_638 3970-0837 4.09 µM -0.0721989613908094 0.483341185210874 no 1759 0.47122178585427 575 4118451 YLR208W SEC13 SGTC_992 3909-8734 162 µM -0.0724989118290182 0.483217841605255 no 1760 0.471102435713318 598 4288319 SGTC_3310 9130229 44.1445 µM -0.0734133843075314 0.482841808333646 no 1761 0.470738583599205 610 7761258 SGTC_2647 atorvastatin 60.16 µM -0.0736966328233263 0.482725338946321 no 1762 0.47062588906133 583 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1615 st002656 86.5 µM -0.0749936997754132 0.482192014999763 no 1763 0.470109862314582 575 1584458 SGTC_2863 9028737 58.44 µM -0.0767549922905713 0.481467863429604 no 1764 0.469409228004348 618 6460917 SGTC_2255 7941087 197.44 µM -0.0771501166002666 0.481305417245135 no 1765 0.469252062245696 578 935561 SGTC_2191 5911152 200 µM -0.0774846635900942 0.48116787844472 no 1766 0.46911899563698 587 2875902 SGTC_1924 st058459 75.1 µM -0.07770568751226 0.481077012422949 no 1767 0.469031084904157 607 688683 SGTC_541 4513-1321 94 µM -0.0777499675672168 0.481058808391892 no 1768 0.469013473000667 570 747515 SGTC_3253 9135987 49.47 µM -0.0781031087668673 0.480913629470186 no 1769 0.468873017156228 595 4182430 SGTC_1224 0823-0416 294 µM -0.0785014969565647 0.480749852220716 no 1770 0.46871456975008 593 3598164 SGTC_278 4092-0821 23.9 µM -0.0785484596935803 0.480730546069037 no 1771 0.468695892002648 602 877900 SGTC_1552 6-methylflavone 10.6 µM -0.0787624471162567 0.480642577458185 no 1772 0.468610787038629 581 689013 SGTC_1365 1672-3266 55.4 µM -0.0795944710126893 0.480300547725268 no 1773 0.468279896379441 581 6415873 SGTC_98 0074-0023 107.663 µM -0.0809424799094886 0.47974643693426 no 1774 0.467743848347469 621 3563821 SGTC_897 1000-0139 31.4 µM -0.0815431653942055 0.479499532479053 no 1775 0.467504999066043 600 6151020 SGTC_3333 9141820 12.094 µM -0.0818038414380508 0.479392387206841 no 1776 0.467401350644663 599 1939433 SGTC_248 streptozotocin 5.23457 mM -0.0830761219505868 0.47886946522355 no 1777 0.466895506062199 599 5300 DNA alkylating agent. SGTC_2111 5486399 200 µM -0.083872077964399 0.478542336547364 no 1778 0.466579069937605 593 689674 SGTC_1744 st037937 38.9 µM -0.0838909386443991 0.478534585201412 no 1779 0.466571572039379 601 1016152 SGTC_1547 harmine 94.2 µM -0.0843284849052522 0.47835476510268 no 1780 0.466397632689182 574 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_183 3914-0051 30.55 µM -0.0846450879543279 0.478224652254398 no 1781 0.46627177633226 581 1596232 SGTC_938 3126-1755 342 µM -0.0851258584354783 0.478027076740377 no 1782 0.466080666429151 578 1777771 SGTC_464 bw-b 70c 158 µM -0.0859147917913921 0.477702871567736 no 1783 0.465767076420185 617 5353454 SGTC_2295 7971645 200 µM -0.0866361966508904 0.477406429542119 no 1784 0.465480346645824 599 2978226 YKL099C UTP11 SGTC_2063 5246145 200 µM -0.087923356816162 0.476877536668549 no 1785 0.464968796218862 608 711240 SGTC_935 2996-0153 430 µM -0.0890551835936801 0.476412503755448 no 1786 0.464519027063963 587 23738523 SGTC_3341 9147222 25.867 µM -0.0894858306197331 0.47623557250124 no 1787 0.46434790696606 604 1939759 SGTC_1173 0443-0020 122 µM -0.0903382346741727 0.475885376295252 no 1788 0.464009218736749 594 5331295 SGTC_3217 9129673 49.47 µM -0.0917631709420267 0.475300006360604 no 1789 0.463443102945734 608 17248312 SGTC_2425 5628681 7.85 µM -0.093830877357791 0.474450678832389 no 1790 0.462621751649144 582 5714958 SGTC_706 4262-0057 46.9 µM -0.0961055402235559 0.473516476491746 no 1791 0.461718375607787 600 883298 SGTC_1917 st066507 28.5 µM -0.0982265909122214 0.472645493662827 no 1792 0.460876184033122 594 3156428 SGTC_14 0354-0009 295 µM -0.0990407243721632 0.472311214486703 no 1793 0.460552967833332 587 1713507 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0998094307728516 0.471995605332537 no 1794 0.460247810383504 610 521171 SGTC_2462 5162487 171.77 µM -0.0998834355734578 0.471965221974678 no 1795 0.460218433538603 591 2259986 SGTC_2486 5283202 22.39 µM -0.102223681474839 0.471004497377194 no 1796 0.459289565558554 599 1377751 SGTC_1304 1165-0502 251 µM -0.103113819673155 0.470639119228282 no 1797 0.458936318488372 590 767425 SGTC_1212 0520-0165 585 µM -0.103178795208801 0.470612449456431 no 1798 0.458910534525344 652 5403258 SGTC_2521 angolensin 13.4 µM -0.103796174200916 0.470359047490541 no 1799 0.458665551308272 581 821428 A flavenoid. SGTC_3301 9125354 19.7965 µM -0.10546098666248 0.469675788672757 no 1800 0.458005012721351 592 41905162 SGTC_2645 abamectin 100 µM -0.106327273935861 0.469320289270497 no 1801 0.45766134638628 586 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_569 4130-2812 160 µM -0.108046078413604 0.468615013981419 no 1802 0.456979570418836 612 743552 SGTC_287 k060-0039 29.6 µM -0.108251818883662 0.468530599260372 no 1803 0.456897970449358 603 5861974 SGTC_2257 7960413 200 µM -0.108814775589478 0.468299626992072 no 1804 0.456674702092591 596 2974689 YIL048W NEO1 SGTC_3280 9140961 49.47 µM -0.109029551051423 0.468211510811095 no 1805 0.456589525848867 609 4901226 SGTC_1443 4112-3303 14 µM -0.109029850599941 0.46821138791606 no 1806 0.456589407054484 587 704433 SGTC_694 1315-0438 43.2 µM -0.111387221416594 0.467244329943946 no 1807 0.455654646417203 603 6793154 SGTC_2100 5377183 190 µM -0.111615583200127 0.467150659874657 no 1808 0.45556410781309 596 2844202 SGTC_206 4546-0025 72.014 µM -0.111653122717705 0.467135261985256 no 1809 0.455549224740006 635 6620745 YIL048W NEO1 SGTC_3145 9085516 49.47 µM -0.113448322630575 0.46639896805899 no 1810 0.454837565523435 591 25236195 SGTC_588 3970-1144 52.9 µM -0.114717226022167 0.465878601716603 no 1811 0.454334629839924 601 1888707 SGTC_910 3454-3003 490 µM -0.115502417731313 0.465556630524226 no 1812 0.454023452115745 601 820824 SGTC_2911 7942208 15.64 µM -0.115763806125313 0.465449452095533 no 1813 0.453919868066152 596 1243384 SGTC_1402 3909-7673 35.9 µM -0.117301798181104 0.464818872307453 no 1814 0.453310450063722 595 5328014 SGTC_1424 4048-1941 275 µM -0.117685464060252 0.464661582243507 no 1815 0.453158442367666 589 X1424 SGTC_3100 9120536 49.47 µM -0.118000156596639 0.464532573043664 no 1816 0.453033766902065 642 16421196 SGTC_1487 3970-0795 2.82 µM -0.119630982970383 0.46386407064622 no 1817 0.452387737555532 601 3765103 SGTC_179 1273-0063 6.77 µM -0.12066854088598 0.463438811667572 no 1818 0.451976788804754 635 3108139 SGTC_774 k060-0086 136 µM -0.120877679071299 0.463353098227221 no 1819 0.451893961017478 614 5911235 SGTC_2663 amphotericin b 100 µM -0.121916132879979 0.462927522367124 no 1820 0.451482719374199 609 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_479 n-linoleoylglycine 10 µM -0.121970870973952 0.462905090947239 no 1821 0.451461043795067 619 6433346 An anti-infammatory. SGTC_721 1187-1332 279 µM -0.12243896328661 0.462713273688679 no 1822 0.451275691194022 610 25730 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.123009745016015 0.462479387572685 no 1823 0.451049690584512 607 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2717 st081029 62.2815 µM -0.123512058709639 0.462273567958749 no 1824 0.450850812967887 618 5292846 SGTC_713 1488-1073 324 µM -0.124561407617699 0.461843637048581 no 1825 0.450435391317569 615 3312542 SGTC_1406 3909-7906 11.9 µM -0.125314252473886 0.461535214863247 no 1826 0.450137384642698 612 X1406 SGTC_35 0133-0054 64.071 µM -0.126228656739358 0.461160636853959 no 1827 0.449775463995791 613 99677 SGTC_442 cape 100 µM -0.126279216655318 0.461139926412217 no 1828 0.449755453628054 600 5281787 SGTC_1270 0831-1170 17.3 µM -0.126377021065366 0.461099863896855 no 1829 0.449716745417439 599 6764716 SGTC_1649 st011737 51.3 µM -0.126911809337385 0.460880811611477 no 1830 0.449505099862152 598 1761035 SGTC_924 2046-0044 21.3 µM -0.127755980749785 0.460535058432733 no 1831 0.449171043393533 597 3623589 SGTC_1120 ficusin 1.78878 µM -0.128315737168597 0.460305811522977 no 1832 0.448949555797944 618 6199 A DNA cross-linker. SGTC_536 3852-0578 10.6 µM -0.129571247080345 0.459791668523316 no 1833 0.448452826471294 604 2869208 SGTC_2491 paeonol 100 µM -0.12965656955357 0.459756730606054 no 1834 0.448419072453205 612 11092 Increases levels of cortical cytochrome oxidase. SGTC_2149 5554786 194.827 µM -0.130112429575844 0.459570069937238 no 1835 0.44823873816948 605 745063 YPR165W RHO1 SGTC_2516 gossypol 71.55 µM -0.130186084265305 0.45953991144077 no 1836 0.448209602013829 621 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_312 4092-0653 6.84 µM -0.133477109818846 0.458192615104427 no 1837 0.446908032996687 609 1148278 SGTC_3218 9131285 49.47 µM -0.134537278450808 0.457758699537077 no 1838 0.446488867543646 627 17156417 SGTC_1246 0422-0085 105 µM -0.134626675418851 0.457722112618214 no 1839 0.446453524836059 626 264295 SGTC_1440 4100-1550 40 µM -0.134854923067874 0.457628700805083 no 1840 0.446363290037808 628 742806 SGTC_2489 cantharidin 73.42 µM -0.13791690025968 0.456375795376327 no 1841 0.445153046786703 603 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_103 0844-0104 51.839 µM -0.139469466891925 0.455740678205027 no 1842 0.444539590995906 608 5375804 SGTC_1699 st031318 29.054 µM -0.139858315019657 0.455581627557354 no 1843 0.444385968647181 632 5340658 SGTC_1398 3558-0053 112 µM -0.140889367780313 0.455159930316662 no 1844 0.443978670822969 627 4532369 SGTC_2282 7944268 200 µM -0.142392268364463 0.454545339463586 no 1845 0.443385084555944 633 2970414 SGTC_1451 4152-0210 104 µM -0.142756625792596 0.45439635675511 no 1846 0.443241196867175 663 659563 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.144398200197436 0.453725210561057 no 1847 0.442593018975201 629 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2698 st077697 67.5 µM -0.145486288454854 0.453280425995628 no 1848 0.442163470398986 604 3154499 SGTC_1626 st003712 1.76 µM -0.146469283868918 0.452878651251193 no 1849 0.441775468154154 649 24207035 SGTC_1819 st053448 58.6 µM -0.146809688384564 0.452739530658314 no 1850 0.441641118662012 601 2857616 SGTC_1923 st058458 19.1 µM -0.146871812159392 0.452714141795731 no 1851 0.441616600623148 661 3534982 SGTC_2409 alverine citrate 63.97 µM -0.147362978493576 0.452513417817786 no 1852 0.441422762667561 612 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2291 7917025 104.35 µM -0.14846047173518 0.452064951344879 no 1853 0.440989689598089 614 2964612 SGTC_1039 k821-0043 94 µM -0.149127659793361 0.451792349473246 no 1854 0.44072645028237 599 15992768 SGTC_2082 5219693 150 µM -0.150125855382102 0.451384545944379 no 1855 0.440332660751592 625 2834649 SGTC_3144 9087057 49.47 µM -0.150668438769282 0.451162900039269 no 1856 0.440118635589801 682 17249618 SGTC_1720 st037298 9.481 µM -0.150784980133991 0.451115294748799 no 1857 0.440072667453487 659 597396 SGTC_2189 6047310 154.431 µM -0.151970789972143 0.450630950416916 no 1858 0.439604987124231 608 711535 SGTC_1084 voriconazole 435 nM -0.152447864480912 0.450436109907408 no 1859 0.439416853909773 628 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2747 doxorubicin 7.63 µM -0.152466060692858 0.450428678685524 no 1860 0.439409678546852 596 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2616 abietic acid 100 µM -0.152760994494317 0.450308231946882 no 1861 0.4392933792576 604 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2406 ethylparaben 405.7 µM -0.153066429467585 0.450183501504303 no 1862 0.439172944633894 663 8434 A possible steroid mimic. SGTC_986 1493-0483 84 µM -0.153071851639337 0.450181287297105 no 1863 0.439170806693756 618 40079 SGTC_3281 9140613 49.47 µM -0.153449109200391 0.450027233574785 no 1864 0.439022059941059 616 16013766 SGTC_981 1488-1094 54.9 µM -0.154511698482414 0.449593364108126 no 1865 0.438603143964773 595 3449522 SGTC_2934 9036370 36.88 µM -0.155044927833242 0.449375662079 no 1866 0.43839294912154 617 6462800 SGTC_122 0236-0016 402.397 µM -0.155451525970814 0.449209670125764 no 1867 0.43823268298692 621 6808838 SGTC_2869 9037858 32.47 µM -0.159044588582904 0.447743207247739 no 1868 0.436816872144441 599 27187042 SGTC_3241 9133421 49.47 µM -0.16051535857227 0.447143135956206 no 1869 0.436237562049582 615 17018221 SGTC_1061 3448-9325 110 µM -0.160548015493118 0.447129813364006 no 1870 0.43622470061766 622 723482 SGTC_2074 5212007 75.395 µM -0.160656097896955 0.447085720906551 no 1871 0.436182134486635 601 758611 SGTC_846 0335-0850 148 µM -0.160658145938433 0.447084885409779 no 1872 0.436181327912875 623 6819598 SGTC_3237 9133362 49.47 µM -0.160860069476566 0.447002512028419 no 1873 0.436101806301856 653 43845137 SGTC_1808 st050063 61.5 µM -0.160894436532968 0.446988492441027 no 1874 0.436088272110667 626 4011993 SGTC_778 3456-2434 196 µM -0.161031015906972 0.44693277734169 no 1875 0.436034486127001 626 5539063 SGTC_2001 4023502 57.655 µM -0.161080304608669 0.446912671159387 no 1876 0.436015076156369 610 108941 YCR052W RSC6 SGTC_1342 1486-1464 234 µM -0.162065332342216 0.446510880629771 no 1877 0.435627203012936 626 3253938 SGTC_2279 7948423 32.93 µM -0.162468335357476 0.446346512437787 no 1878 0.435468530844263 603 1247112 SGTC_1337 1486-1011 40.3 µM -0.163688295828333 0.445848997535915 no 1879 0.434988265921443 607 X1337 SGTC_2891 9063876 19.48 µM -0.164275124974438 0.445609711702627 no 1880 0.434757281523524 607 6472478 SGTC_1308 1187-1617 41.4 µM -0.165129287015714 0.445261453462653 no 1881 0.434421110863228 623 2882570 SGTC_1850 st056238 17 µM -0.166421547100994 0.444734654627238 no 1882 0.433912609130426 626 5393177 SGTC_3005 9076496 71.4286 µM -0.168045866102338 0.44407262820608 no 1883 0.433273598088361 626 21368410 SGTC_1499 4480-0877 67.3 µM -0.168220457978706 0.444001478756013 no 1884 0.433204923571233 599 2861909 SGTC_2038 4100038 30.985 µM -0.168566876447986 0.443860312105888 no 1885 0.433068668215432 633 3596803 SGTC_1012 4112-3522 18 µM -0.168682498560784 0.443813197304377 no 1886 0.433023192814142 638 3112398 SGTC_674 0498-0004 451 µM -0.169591192849207 0.443442941586009 no 1887 0.432665824651487 623 4231473 SGTC_3316 9136639 10.545 µM -0.169852795236911 0.443336358462154 no 1888 0.432562952760914 652 4903665 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.170363019205796 0.443128492709902 no 1889 0.432362326678274 625 1377 SGTC_1194 1488-0194 225 µM -0.171751452888641 0.442562922851809 no 1890 0.431816466617633 625 1391452 SGTC_3132 9126706 49.47 µM -0.171857109575939 0.442519889032253 no 1891 0.431774933208214 626 850858 SGTC_1718 roemerine 11.9335 µM -0.173236783490192 0.441958012229222 no 1892 0.431232655839099 636 235224 An aporphine alkaloid with mutagenic activity. SGTC_3056 9094900 49.47 µM -0.173604920194319 0.441808107016186 no 1893 0.431087982493343 635 25236784 SGTC_1847 st056231 15 µM -0.173715127705961 0.441763232153219 no 1894 0.431044674049563 619 5393180 SGTC_2358 9037157 4 µM -0.174270303310252 0.441537184265847 no 1895 0.430826518314307 617 2388925 SGTC_2871 9038510 12.99 µM -0.175872223769081 0.44088504585323 no 1896 0.430197163704943 625 4945164 SGTC_2095 5432005 200 µM -0.176241539527595 0.440734720863899 no 1897 0.430052093841859 621 783734 SGTC_249 wiskostatin 11.211 µM -0.176385377987788 0.440676175671772 no 1898 0.42999559562296 623 2775510 A n-wasp and actin depolymerizer. SGTC_718 1130-0073 349 µM -0.177851179113667 0.440079638820735 no 1899 0.42941992644414 653 6740020 SGTC_2536 dehydroabietamide 32.04 µM -0.179067092393612 0.439584901920581 no 1900 0.428942510400446 637 3983547 SGTC_2614 arthonioic acid 13.39 µM -0.179738612364242 0.439311710891397 no 1901 0.428678889388023 647 6710684 SGTC_2012 4023501 200 µM -0.180026165736592 0.439194735856506 no 1902 0.428566013247896 659 3477460 SGTC_1018 4259-0013 28.1 µM -0.183781434230397 0.437667605683148 no 1903 0.427092460694723 643 6801262 SGTC_3106 9121286 49.47 µM -0.184406327314979 0.437413573998641 no 1904 0.4268473532307 615 15943471 SGTC_449 xestospongin c 11.1929 µM -0.185291502681068 0.43705377647676 no 1905 0.426500201255228 659 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1641 st009299 47.1 µM -0.185443591321691 0.436991962189326 no 1906 0.426440560186166 632 4046054 SGTC_2727 riluzole 51.77 µM -0.185617674233866 0.436921210527859 no 1907 0.426372296199206 616 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2798 7813637 45.45 µM -0.186826449612142 0.436429989661679 no 1908 0.425898354118384 627 956368 SGTC_2083 5306046 65.942 µM -0.187514671974648 0.436150354325516 no 1909 0.425628560571492 634 539837 SGTC_2453 5731132 22.18 µM -0.18789439506609 0.435996080642427 no 1910 0.425479718287983 664 1362040 SGTC_1310 1188-0297 994 nM -0.187985300071237 0.435959149252055 no 1911 0.425444087295478 634 1588352 SGTC_3101 9120531 49.47 µM -0.188409130232874 0.43578696988063 no 1912 0.425277971488672 693 24824904 SGTC_1355 1499-0035 1.68 µM -0.191407068110153 0.43456941851437 no 1913 0.42410334144587 634 1548538 SGTC_2729 fluphenazine 10.66 µM -0.192207984828462 0.434244247031517 no 1914 0.423789645764936 629 3372 An atypical antipsychotic. SGTC_1469 k284-2957 126 µM -0.192279875144427 0.434215061798983 no 1915 0.423761490787131 631 23884841 SGTC_2101 5377231 179.231 µM -0.193055872142525 0.433900054007495 no 1916 0.423457605696193 666 2844213 SGTC_2499 avocadenofuran 51.48 µM -0.193216771433403 0.433834743885878 no 1917 0.423394602258395 670 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_349 k015-0014 24 µM -0.193456617627711 0.43373739203041 no 1918 0.423300689167784 635 2196908 SGTC_311 1315-0136 58 µM -0.194105448614733 0.433474056332679 no 1919 0.423046657695064 635 6759207 SGTC_2154 5570129 200 µM -0.197093831098039 0.432261569105164 no 1920 0.42187705540861 643 673366 SGTC_2972 9093619 59.92 µM -0.197415156055742 0.432131234536612 no 1921 0.421751335091358 624 25236256 SGTC_489 paxilline 115 µM -0.198075139615167 0.431863557774568 no 1922 0.421493137589704 677 105008 A toxic potassium channel blocker. SGTC_1939 st074455 53.6 µM -0.198899985264518 0.43152906007798 no 1923 0.421170490520612 644 1644229 SGTC_2845 9003024 42.97 µM -0.199321773840829 0.431358032114287 no 1924 0.421005523913384 626 2990173 SGTC_945 3381-0768 11.3 µM -0.200052207997145 0.431061884169159 no 1925 0.420719875111641 656 1126236 YIL048W NEO1 SGTC_2932 9016711 44.54 µM -0.200194417858883 0.431004230964552 no 1926 0.420664266356137 664 7117328 SGTC_1066 ketoconazole 628 nM -0.20026652978769 0.430974996677594 no 1927 0.420636068813773 657 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1175 0741-0056 27.6 µM -0.200790614161168 0.430762543437779 no 1928 0.42043115114327 634 765927 SGTC_534 k292-0788 63.4 µM -0.201017696089468 0.430670495219877 no 1929 0.42034236850686 666 4146317 SGTC_2239 6685329 187.64 µM -0.201203326852779 0.430595252131352 no 1930 0.420269795118457 642 805680 SGTC_2014 4013930 200 µM -0.202082591299776 0.430238887655294 no 1931 0.419926078616051 666 64556 SGTC_1094 duloxetine 25.4 µM -0.202375871585008 0.43012003424567 no 1932 0.419811444908989 629 60834 A selective serotonin reuptake inhibitor. SGTC_186 3455-3465 67.277 µM -0.203442403436863 0.429687869944524 no 1933 0.419394629789246 627 755278 SGTC_1968 st069590 43.6 µM -0.20412268423884 0.429412260564108 no 1934 0.419128814027779 640 6384066 SGTC_2148 5546263 113.568 µM -0.204186554314115 0.429386385967335 no 1935 0.419103859061329 648 792097 SGTC_1200 1643-0193 18.4 µM -0.20459182703206 0.429222211801502 no 1936 0.418945520709958 659 5403974 SGTC_3130 9127414 49.47 µM -0.205312350625291 0.428930361163855 no 1937 0.418664047597645 638 1494646 SGTC_1670 st016595 4.04 µM -0.205604471814441 0.428812047499886 no 1938 0.418549942077964 631 597879 SGTC_1707 st032323 6.317 µM -0.206901761936187 0.428286702074017 no 1939 0.418043290232879 642 3132057 YMR211W DML1 SGTC_2037 5169046 200 µM -0.207034683669116 0.428232881781051 no 1940 0.417991385809042 647 5718022 SGTC_2959 9079155 11 µM -0.208413497652704 0.427674675983988 no 1941 0.417453059058659 639 16189457 SGTC_430 0958-0115 16.4 µM -0.208801024045663 0.427517813911886 no 1942 0.41730178594187 652 6833180 SGTC_3242 9133940 49.47 µM -0.2089891382778 0.427441673580182 no 1943 0.41722835890012 661 17248444 SGTC_2122 5258151 111.688 µM -0.209399656403642 0.42727552336404 no 1944 0.417068130484377 652 2173356 SGTC_1759 st043059 70 µM -0.209822863062356 0.427104251183831 no 1945 0.41690296405405 670 669426 SGTC_338 4055-0136 114 µM -0.209873513395168 0.427083753860844 no 1946 0.416883197543149 629 2900563 SGTC_1669 st015249 58.4 µM -0.20996535525992 0.427046587531885 no 1947 0.416847356395153 646 722793 SGTC_584 0986-0246 15.4 µM -0.210747180542854 0.426730226746374 no 1948 0.416542278281256 665 53315 YDR232W HEM1 SGTC_2365 9042475 200 µM -0.21090056578332 0.426668165877209 no 1949 0.416482431312617 634 6464479 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.212127773198533 0.426171693643964 no 1950 0.416003676421017 673 6728940 SGTC_629 3448-6466 76.7 µM -0.212662000673321 0.425955606037366 no 1951 0.415795303910797 665 573744 SGTC_1525 8-methoxypsoralen 92.5 µM -0.212830244630624 0.425887558289479 no 1952 0.415729686172373 703 4114 Related to psoralen; DNA damaging agent. SGTC_625 k213-0058 121 µM -0.213815716167785 0.42548902004761 no 1953 0.415345384316902 632 3655420 SGTC_1785 bathophenanthroline 24 µM -0.214145506502326 0.425355665279526 no 1954 0.415216794874231 636 72812 An iron chelator. SGTC_2184 6075246 200 µM -0.214742178091323 0.425114415512623 no 1955 0.414984168125633 628 2267320 SGTC_1500 4488-1866 171 µM -0.216640769386671 0.424346952900771 no 1956 0.414244155398906 672 2900003 SGTC_2540 epiandrosterone 100 µM -0.216858816809785 0.424258830462286 no 1957 0.414159186626557 648 441302 A steroid. SGTC_1481 3346-2004 36 µM -0.217076408149918 0.424170896121249 no 1958 0.414074399585832 650 2770522 SGTC_1772 st048439 82.2 µM -0.21914799557763 0.423333903212663 no 1959 0.413267382132192 622 2927068 YDL195W SEC31 SGTC_2828 7998861 71.43 µM -0.219676260641031 0.423120521064584 no 1960 0.413061647162309 629 2988188 SGTC_1160 4092-0570 10.5 µM -0.219986288262731 0.422995302079709 no 1961 0.412940916761871 631 4994975 SGTC_354 2783-3500 4.88 µM -0.221234569144675 0.422491204990089 no 1962 0.412454896889037 637 6740761 SGTC_313 3474-0040 5.03 µM -0.221438055473893 0.422409042492266 no 1963 0.41237568191018 632 1043375 YIL048W NEO1 SGTC_898 1000-0849 28.3 µM -0.223078921766075 0.42174662694883 no 1964 0.411737041504498 649 6751807 SGTC_2449 5812982 45.77 µM -0.223681369465799 0.421503475069103 no 1965 0.41150262183607 631 776185 SGTC_1137 ixabepilone 100 µM -0.224387463395819 0.421218528985798 no 1966 0.411227912381258 614 154225 A novel microtubule stabilizer. SGTC_306 1672-3436 11.6 µM -0.22561857486246 0.420721809442633 no 1967 0.410749046337926 670 6797378 SGTC_2788 5282734 71.43 µM -0.225765291181302 0.420662621852295 no 1968 0.410691986873468 686 743706 SGTC_2897 9048598 12.99 µM -0.225775895883417 0.420658343823958 no 1969 0.410687862670486 640 6467404 SGTC_1862 st057513 3.81 µM -0.22613015659297 0.420515437385087 no 1970 0.41055009521115 638 5393163 SGTC_1736 st036774 51 µM -0.229003100629296 0.419356899218114 no 1971 0.409433253103564 701 1272247 SGTC_880 0833-0487 87.2 µM -0.229354157799389 0.419215380254017 no 1972 0.409296831634911 636 76075 SGTC_1839 st053978 48 µM -0.229588512324273 0.419120912541133 no 1973 0.409205767143691 633 3788398 SGTC_2237 6667747 47.222 µM -0.231407800407949 0.41838772113515 no 1974 0.408499002881101 667 729940 YDL015C TSC13 SGTC_1104 tacrolimus 29.8 µM -0.233344261193898 0.417607619435227 no 1975 0.407747045793523 647 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1614 st002383 48.6 µM -0.236479383959598 0.416345326166362 no 1976 0.406530351445227 654 1947235 SGTC_2480 5767542 37.17 µM -0.236583714404753 0.416303334393085 no 1977 0.406489877797102 637 2867358 SGTC_3017 9080681 49.47 µM -0.236841565059101 0.416199556645838 no 1978 0.406389852253892 664 16451914 SGTC_2386 9075165 157.42 µM -0.237600602797467 0.415894098914693 no 1979 0.406095441468856 646 16452277 SGTC_1961 st076550 68.7 µM -0.237783227979032 0.415820613077521 no 1980 0.406024613879396 658 1579337 SGTC_2268 7933382 153.85 µM -0.238092832617546 0.415696039196144 no 1981 0.405904546829751 633 935025 YOR257W CDC31 SGTC_2736 butenafine 14.65 µM -0.238215017906687 0.415646878517579 no 1982 0.405857164873985 657 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_988 1497-1057 103 µM -0.238550076132946 0.4155120761863 no 1983 0.405727240483517 674 3533044 SGTC_366 0181-0206 4.31 µM -0.240003520416465 0.414927434395076 no 1984 0.405163763730867 671 274874 SGTC_1312 1218-2183 165 µM -0.241141460228305 0.414469834334304 no 1985 0.404722740047281 641 6744073 SGTC_3297 9117502 71.43 µM -0.241729753923887 0.414233309093359 no 1986 0.404494786428351 635 7453720 SGTC_2601 securinine 100 µM -0.243285906207049 0.41360780357331 no 1987 0.403891960839213 645 442872 A GABA receptor antagonist. SGTC_1562 morin hydrate 59.1 µM -0.243677585882617 0.413450399844804 no 1988 0.403740267021518 679 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3122 9126309 49.47 µM -0.243768554267975 0.413413844504435 no 1989 0.403705037900877 665 17591206 SGTC_2346 9031566 143.75 µM -0.244373149182223 0.413170909152102 no 1990 0.403470917660139 660 4771086 SGTC_115 0527-0192 112.043 µM -0.24519872846862 0.412839232653321 no 1991 0.403151280439419 673 4233931 SGTC_3340 9146634 11.102 µM -0.245736224242193 0.412623327135824 no 1992 0.402943214465574 670 4907387 SGTC_3305 9127027 53.8275 µM -0.246328269417443 0.412385540382943 no 1993 0.402714064087385 658 41905295 SGTC_2794 7785382 27.27 µM -0.247229692020796 0.412023558245237 no 1994 0.402365233741834 684 2205081 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.247773859075261 0.411805074578469 no 1995 0.402154690895931 675 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1773 st048542 73.5835 µM -0.247993226702202 0.411717005964878 no 1996 0.402069823726317 656 3237138 SGTC_9 0092-0002 10.449 µM -0.248306489364063 0.411591249410891 no 1997 0.40194863921139 654 759368 SGTC_2997 9067075 71.4286 µM -0.24948767657238 0.411117153924782 no 1998 0.401491786130256 680 27209819 SGTC_38 0929-0051 58.268 µM -0.249528330812127 0.411100838757247 no 1999 0.40147606450021 679 1379719 SGTC_3351 9150312 21.596 µM -0.249670198189576 0.411043906415906 no 2000 0.401421203417063 657 4904905 SGTC_2413 inermin 26.06 µM -0.249672797924313 0.411042863142191 no 2001 0.401420198100024 692 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3151 9099821 49.47 µM -0.251389592038328 0.41035405129845 no 2002 0.400756456872936 697 17174189 SGTC_1093 fluphenazine 7.97 µM -0.253615110131618 0.409461541051953 no 2003 0.399896461014606 678 6602611 An atypical antipsychotic. SGTC_835 0312-0010 67.2 µM -0.254050235746278 0.409287095202703 no 2004 0.399728374182236 671 1626196 SGTC_1650 st011916 45.8 µM -0.256067414601232 0.408478624869921 no 2005 0.398949391344947 679 242528 SGTC_1123 mangostin 811.285 nM -0.256932651913038 0.408131963289843 no 2006 0.398615381949608 653 5281650 An antioxidant. SGTC_1506 4226-2149 212 µM -0.257724751535729 0.407814667711507 no 2007 0.398309671141928 683 991114 SGTC_1359 1582-0056 520 nM -0.257805571834035 0.407782296488141 no 2008 0.398278482057426 672 3661189 SGTC_1330 1469-0054 61.8 µM -0.25998886088422 0.406908055369252 no 2009 0.397436182976165 678 7102664 SGTC_919 tnp00227 403.569 nM -0.260244929749483 0.406805549571689 no 2010 0.397337424475982 686 1269246 A methoxyflavone. YNL221C POP1 SGTC_642 0335-0876 158 µM -0.261029230001421 0.406491629550724 no 2011 0.397034983081743 637 6812350 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.262032868139827 0.4060900061333 no 2012 0.39664805106965 649 756377 SGTC_117 lucigenin 22.078 µM -0.262664170031797 0.405837430193073 no 2013 0.39640471773256 696 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_121 0557-0495 61.343 µM -0.264393923411989 0.405145578748307 no 2014 0.39573819670118 673 3104427 SGTC_974 1326-0144 138 µM -0.266139844713368 0.404447561084638 no 2015 0.395065754776395 691 5411856 SGTC_1004 4084-0029 199 µM -0.266595241353832 0.404265543847044 no 2016 0.394890409962351 660 716894 YLR208W SEC13 SGTC_1618 st003135 44.5 µM -0.269799050828862 0.402985602783771 no 2017 0.393657426541375 704 1270615 SGTC_217 ketoconazole 989 nM -0.269929946988562 0.402933330981057 no 2018 0.393607073834592 651 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2696 st077691 74.316 µM -0.271098791624914 0.402466643984935 no 2019 0.393157525466811 698 757133 SGTC_1050 3232-1156 69.3 µM -0.271490862247972 0.402310132235315 no 2020 0.393006763380982 673 700529 SGTC_1332 1480-0653 17.5 µM -0.273323422643286 0.401578795456836 no 2021 0.392302305951658 691 5749438 SGTC_1265 0819-1001 68.8 µM -0.273499122125776 0.401508695506533 no 2022 0.392234783534186 667 3106768 SGTC_2706 st078239 82.5 µM -0.274763669256385 0.401004264648149 no 2023 0.391748905938394 661 15434492 SGTC_1191 1487-1166 10.6 µM -0.274909545705342 0.400946084784363 no 2024 0.391692866600361 690 3955771 SGTC_1493 4348-0038 111 µM -0.275010698580463 0.40090574330086 no 2025 0.391654009418557 674 800424 SGTC_2229 7354935 190 µM -0.276246422483381 0.400413001062133 no 2026 0.391179401945513 689 318112 SGTC_875 0709-0210 25.7 µM -0.276809140990003 0.400188670732754 no 2027 0.390963330922812 697 6251364 SGTC_371 0195-0006 7.36 µM -0.277299548996621 0.399993194168227 no 2028 0.390775052919102 648 3928593 SGTC_2008 4012253 172 µM -0.277524556103293 0.399903514748679 no 2029 0.390688676498548 669 603940 SGTC_1356 1502-0781 85.8 µM -0.278942861189063 0.399338353070776 no 2030 0.390144337491616 669 567702 SGTC_2634 4'-methoxyflavone 100 µM -0.279346694516912 0.399177473378185 no 2031 0.389989387443458 695 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1203 3992-3522 103 µM -0.279469104425595 0.399128710926082 no 2032 0.38994242245493 739 5322312 SGTC_123 0083-0120 66.675 µM -0.279643963894141 0.39905905772284 no 2033 0.389875336939707 672 16001701 SGTC_2546 rhodinyl acetate 100 µM -0.279694143307025 0.39903906994 no 2034 0.38985608601844 676 6708682 SGTC_3212 9128307 49.47 µM -0.280409025944441 0.398754342115706 no 2035 0.389581856507239 698 27243542 SGTC_303 1348-1668 34.2 µM -0.281137329826088 0.398464324197005 no 2036 0.389302535121614 680 5380509 SGTC_1188 1403-0014 4.57 µM -0.281300774260618 0.39839924667978 no 2037 0.389239858252197 676 9614867 SGTC_1883 5-benzylidenerhodanine 20 µM -0.281741914984355 0.398223614899967 no 2038 0.389070706162107 656 1273210 SGTC_82 0054-0107 293.755 µM -0.28205534307048 0.398098842001056 no 2039 0.388950537293984 680 3104697 SGTC_2374 9071832 200 µM -0.283160137076254 0.397659116631759 no 2040 0.388527042157857 693 17381698 SGTC_2707 st078556 66.6 µM -0.283900631153942 0.397364461088141 no 2041 0.388243266399683 654 17250899 SGTC_882 0843-0131 351 µM -0.284868127694924 0.396979565557763 no 2042 0.387872587553873 667 5425421 SGTC_969 1313-0238 134 µM -0.28487989570167 0.396974884552485 no 2043 0.387868079482529 671 5212874 SGTC_2428 5615643 7.78 µM -0.286521265908167 0.39632213612158 no 2044 0.387239454028642 685 2253075 SGTC_1142 3253-1408 9.78 µM -0.286931133880352 0.396159183007017 no 2045 0.387082525480827 682 256655 SGTC_744 1594-0068 283 µM -0.288655650476861 0.395473757991558 no 2046 0.38642245217972 658 668392 SGTC_648 0375-0473 33.3 µM -0.290332572890424 0.394807559626763 no 2047 0.385780910961524 682 1713139 SGTC_2583 asiatic acid 100 µM -0.290361366308163 0.394796123418118 no 2048 0.385769898168539 694 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2795 7780010 54.55 µM -0.291028099919041 0.394531334631204 no 2049 0.38551491429094 665 953673 SGTC_1989 st071868 50.2 µM -0.291029239810337 0.394530881972699 no 2050 0.385514478396194 691 16414057 SGTC_265 mycophenolic acid 32.932 µM -0.292523092154157 0.393937785757965 no 2051 0.384943353313752 695 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1909 st060837 51.5 µM -0.292831797879681 0.393815252587473 no 2052 0.384825360951192 709 678937 SGTC_1976 st070609 63.5 µM -0.293658526165329 0.393487154864693 no 2053 0.384509424476145 652 682556 SGTC_3162 9099653 49.47 µM -0.294958207150553 0.39297151275734 no 2054 0.384012902962813 652 25237511 SGTC_1399 3562-5772 25 µM -0.296453391368712 0.392378537966235 no 2055 0.383441928135729 660 23847490 SGTC_348 k064-0012 10.7 µM -0.298652325160155 0.391506917431176 no 2056 0.382602668335592 673 5066323 SGTC_2638 epoxomicin 18 µM -0.299603064926124 0.391130228430514 no 2057 0.382239973021709 675 9915668 A protesome inhibitor. SGTC_1550 gossypolone 36.6 µM -0.300935684049803 0.390602408381636 no 2058 0.381731769448727 679 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_571 k831-0106 44.2 µM -0.301145174591085 0.390519452260436 no 2059 0.381651897286498 707 4783639 SGTC_3252 9135871 49.47 µM -0.302850694619712 0.389844269450115 no 2060 0.381001823856499 694 17682838 SGTC_1109 tnp00067 928.257 nM -0.303036922890896 0.38977056531818 no 2061 0.380930861668235 671 676295 SGTC_2053 5265679 138 µM -0.30335694014591 0.389643920370494 no 2062 0.380808928610196 662 764595 SGTC_58 0957-0393 9 µM -0.303399999371393 0.389626880829173 no 2063 0.380792523076087 691 6997992 SGTC_2635 hydroquinidine 100 µM -0.304133529107423 0.389336638596379 no 2064 0.380513081718257 657 442912 An experimental heart treatment. SGTC_3042 9091578 49.47 µM -0.305574978665511 0.388766467397866 no 2065 0.379964136938011 656 25236497 SGTC_927 2425-1185 123 µM -0.30628294695628 0.388486515313394 no 2066 0.379694611038351 685 730375 SGTC_1387 3342-1166 1.8 µM -0.307276662739862 0.388093667749309 no 2067 0.379316398715363 675 3418228 SGTC_2352 9027995 87.8 µM -0.307310671295128 0.388080225105835 no 2068 0.379303456960616 673 2997347 SGTC_503 tyrphostin 8 294 µM -0.307525783193406 0.387995200415467 no 2069 0.379221600532859 721 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_707 0865-0008 204 µM -0.308190903500549 0.387732340300588 no 2070 0.378968536890577 680 723043 SGTC_2819 7996655 46.38 µM -0.309418859435409 0.387247178921557 no 2071 0.378501463029023 697 6456960 SGTC_2814 7977482 42.97 µM -0.309961516250772 0.387032833036893 no 2072 0.378295110800946 686 6456762 SGTC_2973 9094665 17.96 µM -0.310966011386924 0.386636154979773 no 2073 0.377913230238231 717 25237061 YIL048W NEO1 SGTC_314 1671-0008 2.74 µM -0.312126806772844 0.386177901007752 no 2074 0.377472077323731 712 3913060 SGTC_3182 9108849 49.47 µM -0.314543306126956 0.385224435318365 no 2075 0.376554215332862 675 17133045 SGTC_2783 7738165 71.43 µM -0.314551578486046 0.385221172523997 no 2076 0.376551074427321 670 17201110 SGTC_1216 1165-0504 9.65 µM -0.314871835475896 0.385094862604094 no 2077 0.376429483360832 693 6304004 SGTC_428 3448-4153 16.5 µM -0.316238135741556 0.384556128475836 no 2078 0.375910881867799 664 3834874 SGTC_1232 0279-0259 161 µM -0.31667913077814 0.384382291035952 no 2079 0.375743542808946 680 1560000 SGTC_1942 st076330 65.2 µM -0.317773624453305 0.383950949115149 no 2080 0.375328329546861 728 24208414 SGTC_431 k089-0097 107 µM -0.318134973638072 0.383808572284861 no 2081 0.375191277774427 711 5499420 SGTC_3298 9116858 71.43 µM -0.318238669741667 0.38376771740826 no 2082 0.375151951038921 719 2506942 SGTC_2564 betulinic acid 100 µM -0.318514792634792 0.383658934986462 no 2083 0.37504723779289 723 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1768 st044301 37.178 µM -0.319165560222198 0.383402592403019 no 2084 0.374800485618162 718 3931349 SGTC_2146 5545642 200 µM -0.319310891554934 0.383345352190161 no 2085 0.374745387193094 686 825326 SGTC_1419 3993-2473 62.6 µM -0.320297141407372 0.382956975060024 no 2086 0.374371544968709 680 704026 SGTC_1225 1216-0074 20.6 µM -0.320524194923261 0.382867579886048 no 2087 0.374285496071296 682 4241466 SGTC_990 3985-0011 41.3 µM -0.32055882944902 0.382853944180192 no 2088 0.374272370805295 727 5399565 YGL099W LSG1 SGTC_3059 1327-0034 3 µM -0.32076871827844 0.382771313490572 no 2089 0.37419283344564 673 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2894 9048625 32.47 µM -0.321847439240903 0.382346718370008 no 2090 0.373784136749443 687 4092861 SGTC_946 3434-1334 87.4 µM -0.32550172157875 0.380909410880902 no 2091 0.372400689937684 678 4047976 SGTC_838 0109-0203 71.4 µM -0.325533330832509 0.38089698541831 no 2092 0.37238873038251 682 759422 SGTC_1074 carmofur 3.8 µM -0.326314531404829 0.38058993786966 no 2093 0.372093197481363 697 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1133 3473-0247 50 µM -0.326344092274248 0.380578320571717 no 2094 0.372082015903789 704 711311 SGTC_872 0588-0139 234 µM -0.327279299009051 0.380210843887445 no 2095 0.371728324036172 657 2047100 SGTC_1372 2752-0194 270 µM -0.328440435462067 0.379754741668994 no 2096 0.371289337002858 702 823334 SGTC_3084 9116877 49.47 µM -0.328707231398077 0.37964996603326 no 2097 0.37118849397142 716 27241325 SGTC_73 0327-0325 16.231 µM -0.329107716731431 0.379492704718846 no 2098 0.371037135872902 691 53298 SGTC_63 0099-0242 26.702 µM -0.329210486908507 0.379452352463692 no 2099 0.370998298468473 710 3898502 YLR359W ADE13 SGTC_2483 5729050 27.16 µM -0.329512162262224 0.379333908557336 no 2100 0.370884301315539 717 2865180 SGTC_675 1309-0189 238 µM -0.330174063906328 0.379074072148396 no 2101 0.370634221486777 677 4246530 SGTC_3342 9147791 14.508 µM -0.330653298635084 0.378885977634602 no 2102 0.370453191014101 702 1838168 SGTC_3044 9093193 49.47 µM -0.33107845626611 0.378719131809813 no 2103 0.370292612125055 724 25236277 SGTC_603 3794-0023 45.9 µM -0.33117536949841 0.378681103034919 no 2104 0.370256011877066 717 3802260 SGTC_2770 toltrazuril 17.5 µM -0.332563429685087 0.378136556958986 no 2105 0.369731926162452 681 68591 Kills coccidiodes. SGTC_654 1124-0271 80.9 µM -0.333801728927328 0.377650967382336 no 2106 0.369264589345706 701 5403748 SGTC_657 3534-0529 86.7 µM -0.334188100114557 0.377499494407901 no 2107 0.369118811524197 707 1049549 SGTC_107 0358-0022 2.6945 µM -0.334428794989379 0.377405141903032 no 2108 0.369028006878591 731 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1748 st037455 53.6035 µM -0.336394578706724 0.376634828123344 no 2109 0.368286668548292 714 580690 SGTC_412 gemfibrozil 100 µM -0.336957431553853 0.376414358374669 no 2110 0.368074495053833 678 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2086 5274770 176.623 µM -0.339158527723977 0.375552575562614 no 2111 0.367245154838321 690 689278 SGTC_163 TUB2.036 7.546 µM -0.339593711689806 0.375382263769663 no 2112 0.367081257173816 679 15992207 YJR013W GPI14 SGTC_3152 9099253 49.47 µM -0.340381360856955 0.375074074432877 no 2113 0.366784676741895 708 25236131 SGTC_2586 curcumin 80 µM -0.340770903373004 0.37492168469893 no 2114 0.36663802826269 702 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_892 0929-0076 29 µM -0.341423631304158 0.374666380137553 no 2115 0.366392343766691 670 5751038 SGTC_1863 st057641 20.1 µM -0.342264201505648 0.374337684866376 no 2116 0.366076036760018 693 3921635 SGTC_244 nsc-207895 1.295 µM -0.34237830433827 0.374293073305018 no 2117 0.366033106813838 669 42640 SGTC_860 0443-0016 25.1 µM -0.343306791795637 0.373930118862369 no 2118 0.365683835927089 698 5337942 SGTC_1161 k007-0610 110 µM -0.343470357984688 0.37386619087544 no 2119 0.365622318448229 718 5843850 SGTC_585 0kpi-0023 191 µM -0.343503195232971 0.373853357228101 no 2120 0.365609968728444 706 64601 SGTC_3150 9097574 49.47 µM -0.344588476324252 0.373429280031436 no 2121 0.365201885168305 722 17217476 SGTC_2669 eugenol 100 µM -0.34459555068236 0.37342651620464 no 2122 0.365199225593263 704 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_741 4582-0002 126 µM -0.344975047191197 0.373278263166217 no 2123 0.365056564989682 662 2912688 SGTC_3210 9128157 49.47 µM -0.346251231259418 0.372779850405352 no 2124 0.364576958049591 713 17590849 SGTC_1158 4092-0494 91.8 µM -0.346963792785931 0.372501652589899 no 2125 0.364309260090695 712 1148199 SGTC_62 0180-0423 3.232 µM -0.348059352270289 0.372074054736147 no 2126 0.363897805060016 719 30102 YGL099W LSG1 SGTC_351 caspofungin 25 nM -0.348706466132447 0.371821559666194 no 2127 0.363654844678855 672 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1485 3909-9022 254 µM -0.349535773351459 0.371498055812574 no 2128 0.363343559539207 702 714516 SGTC_2999 9069765 71.4286 µM -0.349655275702461 0.371451446701738 no 2129 0.363298711090666 703 2097066 SGTC_649 1123-0311 367 µM -0.350659150424874 0.371059983210766 no 2130 0.362922037536972 723 693629 YIL048W NEO1 SGTC_2782 7736369 71.43 µM -0.352278099501366 0.370428951078813 no 2131 0.362314855420368 702 2950836 YOL077C BRX1 SGTC_157 1348-1695 65.819 µM -0.352654816155328 0.370282164808488 no 2132 0.362173618539976 672 5380510 SGTC_594 1487-1584 10.8 µM -0.352855233466286 0.370204080630104 no 2133 0.362098486645722 728 5013332 SGTC_3294 9122953 26.2835 µM -0.353510572627079 0.369948792636631 no 2134 0.361852851994591 705 16459826 SGTC_1704 st028805 70.8 µM -0.354483236753792 0.369569996056563 no 2135 0.361488382317658 706 2876101 SGTC_769 0302-0231 76 µM -0.354776859623324 0.369455671735443 no 2136 0.361378382752209 716 571869 YER009W NTF2 SGTC_404 fumagillin 50 µM -0.3553436082613 0.369235036444571 no 2137 0.361166094834348 701 12015870 A methionine aminopeptidase binder. SGTC_1060 3448-7350 82 µM -0.355696216056238 0.36909778792993 no 2138 0.361034039552731 724 570178 SGTC_1767 st044992 70.3 µM -0.358056671606339 0.368179438389092 no 2139 0.36015045165472 715 9600693 SGTC_1972 st070201 17.4 µM -0.35872998232367 0.367917620523175 no 2140 0.359898548306541 696 2829099 SGTC_3065 9113888 49.47 µM -0.359765777767866 0.367514969758741 no 2141 0.359511148650217 736 16648368 SGTC_2914 7968218 45.32 µM -0.360899800488565 0.367074301511478 no 2142 0.359087176368119 721 2977111 SGTC_2928 9011484 9.79 µM -0.360921303887262 0.367065947226376 no 2143 0.359079138657811 718 2994751 SGTC_3313 9133968 57.047 µM -0.362212938198866 0.366564249974678 no 2144 0.358596455901517 715 1494643 SGTC_2297 7971671 152.32 µM -0.363283926283992 0.366148429031456 no 2145 0.358196399653153 734 909016 SGTC_763 3453-1109 128 µM -0.363572960065378 0.366036235922462 no 2146 0.358088460797115 723 1560353 SGTC_1229 0139-0193 12.2 µM -0.363938879836765 0.365894214709921 no 2147 0.357951825353604 698 3090752 SGTC_3251 9135047 49.47 µM -0.364511506971164 0.36567200287554 no 2148 0.357738041336653 703 17682963 SGTC_1245 0418-0076 17.2 µM -0.366213142890341 0.365011937751119 no 2149 0.357103017890849 743 6790114 SGTC_1315 1237-0019 3.69 µM -0.366377084124501 0.364948365977081 no 2150 0.357041858498471 703 825140 SGTC_1003 4049-0218 100 µM -0.366917590377654 0.364738799242233 no 2151 0.356840244992569 707 295161 SGTC_2881 9058953 51.95 µM -0.367660085377599 0.364450982706329 no 2152 0.356563353131065 672 17122249 SGTC_500 h-89 112 µM -0.368077180053168 0.364289336004468 no 2153 0.356407842976708 744 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3273 9137859 49.47 µM -0.369099180157309 0.363893357872879 no 2154 0.356026900006818 712 2377234 SGTC_1688 st021091 57.6 µM -0.369709256813003 0.363657050399531 no 2155 0.355799566909853 733 3656366 SGTC_18 0111-0177 500 nM -0.369832104406839 0.363609472805443 no 2156 0.355753796363079 733 721752 SGTC_154 3389-1638 511.116 µM -0.371246209973158 0.36306195606808 no 2157 0.355227078909783 757 5238686 SGTC_549 1661-1316 519 µM -0.37130880399009 0.363037727225944 no 2158 0.355203770652901 733 2857282 SGTC_1692 fluoroquinolonic acid 71 µM -0.373112432701493 0.362339815876215 no 2159 0.354532382900038 732 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2235 salicylic acid 500 µM -0.373478858923548 0.362198083628798 no 2160 0.354396038527075 709 338 A COX inhibitor and kinase inhibitor. SGTC_2715 st079500 56.4 µM -0.373627678398647 0.362140526223556 no 2161 0.354340669274135 709 28246688 SGTC_214 4373-3496 70 µM -0.374568851167572 0.361776590578894 no 2162 0.353990571173291 730 3779166 SGTC_695 3505-6186 243 µM -0.374789118488228 0.361691434954232 no 2163 0.353908653791777 731 1819379 SGTC_2116 5511452 16.8835 µM -0.375019394079983 0.361602417442049 no 2164 0.353823021566069 726 870744 SGTC_903 1134-0042 114 µM -0.375140666717111 0.361555540154226 no 2165 0.353777927071743 698 701009 SGTC_2557 derrustone 83.84 µM -0.376287645427046 0.361112284534201 no 2166 0.35335153153239 754 629853 An antioxidant. SGTC_658 3253-0951 102 µM -0.379661214924261 0.359809634365905 no 2167 0.352098457062777 707 1184878 SGTC_3270 9137563 49.47 µM -0.380012970204621 0.359673903061125 no 2168 0.35196789364594 682 17015724 SGTC_765 1319-0117 244 µM -0.380086819440898 0.359645409209722 no 2169 0.351940484735126 686 3487746 YGL099W LSG1 SGTC_3137 9097352 49.47 µM -0.381744205039046 0.3590061321621 no 2170 0.351325553927121 771 44120435 SGTC_1162 k048-0130 20.1 µM -0.382162324772651 0.358844919740112 no 2171 0.351170482605927 730 6797406 SGTC_3245 9134821 49.47 µM -0.382302832216475 0.358790750600685 no 2172 0.351118377077113 726 17014901 SGTC_1393 3470-5649 58.2 µM -0.38259551758343 0.358677922180377 no 2173 0.35100984714823 725 4108395 SGTC_332 4112-0506 40.9 µM -0.383538800784095 0.358314376234025 no 2174 0.350660153399672 707 2790355 SGTC_2625 euphol 100 µM -0.383680932846663 0.358259608966801 no 2175 0.350607473190652 710 6708538 A triterpene alcohol. SGTC_16 erodoxin 22.806 µM -0.384359977696712 0.357997995172232 no 2176 0.350355829849064 731 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_307 1501-1223 22.3 µM -0.385973543822026 0.35737660850052 no 2177 0.349758131226784 729 2830329 SGTC_2361 9034121 116 µM -0.38621131617412 0.35728507393397 no 2178 0.349670086803719 728 6496917 SGTC_495 decylubiquinone 155 µM -0.387075655854907 0.35695240068603 no 2179 0.349350099701863 744 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_15 0266-0086 27.098 µM -0.387282316183438 0.356872875877374 no 2180 0.349273607851636 729 1712902 YIL048W NEO1 SGTC_416 estradiol valerate 100 µM -0.387323659132448 0.356856967474101 no 2181 0.349258306188077 727 13791 A steroid. SGTC_1416 3966-0321 25.3 µM -0.387697016564065 0.356713314094879 no 2182 0.349120131940343 720 582530 YLR208W SEC13 SGTC_711 k292-0785 179 µM -0.387915933349141 0.3566290929025 no 2183 0.349039123268003 717 4146315 SGTC_2504 purpurogallin 52.29 µM -0.388461347239775 0.356419292857767 no 2184 0.348837326481255 687 5281571 An antioxidant. SGTC_1306 1185-0270 9.02 µM -0.389534056212083 0.356006789188559 no 2185 0.348440561428861 713 1548076 SGTC_485 niflumic acid 177 µM -0.390315818905103 0.355706273242514 no 2186 0.34815151366434 719 4488 A COX2 inhibitor. SGTC_3030 9087619 49.47 µM -0.39096402963279 0.355457163740775 no 2187 0.347911912070746 708 25236973 SGTC_2250 alverine citrate 130 µM -0.391263068972089 0.35534226274872 no 2188 0.347801397022632 705 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_463 ikarugamyin 104 µM -0.391822378217213 0.355127392588387 no 2189 0.347594729540521 728 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_75 0159-0059 199.013 µM -0.392614219785631 0.354823269123412 no 2190 0.347302217690255 769 5377270 SGTC_742 0kpi-0133 140 µM -0.392621190711112 0.354820592202808 no 2191 0.347299642984823 724 2728852 SGTC_678 1218-2179 85.9 µM -0.393886201667777 0.354334931326254 no 2192 0.346832529032031 721 6820081 YOR116C RPO31 SGTC_2114 5491910 81.25 µM -0.394035436353015 0.35427765299662 no 2193 0.34677743843559 731 2849228 SGTC_1379 2144-0755 36.5 µM -0.394217119045611 0.354207925123768 no 2194 0.346710373896719 729 5392327 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.395016103546096 0.353901341462017 no 2195 0.34641550175151 725 94937 An inhibitor of serotonin biosynthesis. SGTC_1195 1502-0147 41.1 µM -0.395355058015634 0.353771307585913 no 2196 0.346290435772349 711 817940 SGTC_1065 prochlorperazine maleate 2.48 µM -0.395622095950489 0.353668875226295 no 2197 0.346191917052096 738 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1394 3474-0001 65.7 µM -0.39584852052176 0.353582029936458 no 2198 0.346108390036576 693 5017666 YIL048W NEO1 SGTC_221 trifluoperazine 10.304 µM -0.396176650742526 0.353456188904522 no 2199 0.345987357546432 728 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2475 5812728 15.03 µM -0.39638848763393 0.353374955967429 no 2200 0.345909228794918 718 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2211 7117706 200 µM -0.396931908530454 0.353166601305673 no 2201 0.345708836694082 720 822771 SGTC_771 0250-0039 27.3 µM -0.396990828295296 0.353144013342499 no 2202 0.345687112014915 721 3005115 SGTC_3311 9131146 2.8755 µM -0.397156242487463 0.353080601569843 no 2203 0.345626123817917 718 4900406 YPR165W RHO1 SGTC_2585 alliin 100 µM -0.397728335037265 0.352861320518249 no 2204 0.345415224248148 756 87310 A garlic compound which reacts with lipids. SGTC_20 0481-0013 4.944 µM -0.397798203940411 0.352834543361723 no 2205 0.345389470650514 725 182045 SGTC_180 1486-1293 102.781 µM -0.398242754234418 0.352664187181001 no 2206 0.345225626691591 732 4140536 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.398320836121928 0.352634268459062 no 2207 0.345196851736663 726 88881 An O-methylated flavonoid and antioxidant. SGTC_2277 7947813 106.88 µM -0.398442902125591 0.352587498121807 no 2208 0.345151869425756 740 1246798 SGTC_641 4092-0595 30 µM -0.399014585632187 0.352368483750152 no 2209 0.344941228548932 710 786260 SGTC_2444 5485484 36.41 µM -0.399920815262628 0.352021403651287 no 2210 0.344607420225819 747 6790631 SGTC_1663 st014140 55.4 µM -0.400629022525789 0.351750250618014 no 2211 0.344346637331319 710 4207120 SGTC_2210 7115885 190.385 µM -0.401576096096902 0.351387760105446 no 2212 0.343998012423104 739 2927039 SGTC_1059 3448-6867 171 µM -0.401950180906051 0.351244617103605 no 2213 0.343860345497346 714 3934407 SGTC_1948 st076329 66.6 µM -0.402207449797132 0.351146185784807 no 2214 0.34376568000124 743 24208413 SGTC_2776 terbinafine 19.92 µM -0.402457708095662 0.351050446306061 no 2215 0.343673603543788 685 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1508 1080-0625 72.9 µM -0.402791906189634 0.35092260933956 no 2216 0.343550657940467 720 767111 SGTC_691 1548-0686 185 µM -0.404958773519945 0.350094152341706 no 2217 0.342753907556739 725 46495133 SGTC_1754 st042065 16.137 µM -0.405011469509754 0.350074013981919 no 2218 0.342734540096505 733 1126236 YIL048W NEO1 SGTC_128 0906-2981 13.371 µM -0.405787315949977 0.349777564447089 no 2219 0.342449439603168 750 6740226 SGTC_941 3237-0776 460 µM -0.406367112373916 0.349556085040612 no 2220 0.342236440245111 734 760008 SGTC_2958 9077254 16.72 µM -0.406884679061923 0.349358420339545 no 2221 0.342046344563944 718 16457351 SGTC_2251 lansoprazole 556 µM -0.407059453565472 0.349291681159529 no 2222 0.341982161143665 742 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1814 st052110 31.539 µM -0.407399789537441 0.349161734251012 no 2223 0.341857190761945 749 674163 SGTC_309 k408-0051 1.48 µM -0.407690963835907 0.349050572263066 no 2224 0.341750286156545 730 3640463 SGTC_1184 1269-1718 139 µM -0.408013182442113 0.348927573546613 no 2225 0.341631998429311 697 5403821 SGTC_1609 st001574 46.4 µM -0.408586285163178 0.348708845460605 no 2226 0.341421648581064 738 3960012 SGTC_499 genistein 192 µM -0.408630661627122 0.348691911013732 no 2227 0.341405362834815 736 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2842 9000675 19.48 µM -0.408968676066118 0.348562931642407 no 2228 0.341281324398024 690 2989072 SGTC_2460 5552655 174.22 µM -0.409186012210072 0.348480009876109 no 2229 0.341201579358939 725 5401989 SGTC_3304 9125678 46.087 µM -0.41089643607544 0.347827672981436 no 2230 0.340574237917626 726 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_820 1582-0060 59.9 µM -0.410896491376837 0.347827651897358 no 2231 0.34057421764155 733 3848840 SGTC_2061 5245884 80.95 µM -0.411875638771284 0.347454418326841 no 2232 0.340215288721834 736 573863 SGTC_1775 st081588 35.1725 µM -0.414750374249088 0.346359475700466 no 2233 0.339162325797576 746 1426443 YGL099W LSG1 SGTC_432 NS 1619 61.3 µM -0.416612625075693 0.345650856924724 no 2234 0.338480886653846 711 4552 A K+/calcium channel activator. SGTC_1497 4476-2978 41.3 µM -0.417437460580589 0.345337165246912 no 2235 0.338179229693564 737 1528379 SGTC_1016 4226-1401 38 µM -0.418495075041411 0.344935101253512 no 2236 0.33779259331152 732 2901613 SGTC_1791 st048313 56.1 µM -0.418557715478336 0.344911293275092 no 2237 0.337769698957708 730 1204976 SGTC_2938 9059746 27.26 µM -0.418805483655257 0.344817129142471 no 2238 0.337679148443567 739 6471769 SGTC_2752 diclazuril 33.15 µM -0.418942762607383 0.344764960504795 no 2239 0.337628981881864 712 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_608 k048-0125 159 µM -0.419177199914572 0.344675876651319 no 2240 0.337543316907942 751 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_598 3937-0236 20.2 µM -0.421513810657981 0.343788459122281 no 2241 0.3366899642746 741 1379313 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.421720399670594 0.343710040332144 no 2242 0.336614556351757 704 6708739 YPR165W RHO1 SGTC_233 rapamycin 362 pM -0.422110699127664 0.343561905546097 no 2243 0.336472109440275 722 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1747 st037496 66.6 µM -0.424848630205069 0.342523423906874 no 2244 0.335473512204264 717 723305 SGTC_43 0570-0105 72.5 µM -0.427118174091422 0.341663499872889 no 2245 0.334646628120195 750 1114046 YDL195W SEC31 SGTC_138 0850-0259 40.9225 µM -0.427396727196431 0.341558013339038 no 2246 0.334545195400045 725 6813004 SGTC_980 1473-0395 201 µM -0.428542283452655 0.341124327626895 no 2247 0.334128177942849 738 768876 SGTC_705 1124-0212 310 µM -0.428618964970649 0.341095304954852 no 2248 0.334100270832562 755 9554485 SGTC_146 3448-8650 53.125 µM -0.42872905765408 0.34105363835935 no 2249 0.334060205823955 761 2891488 YIL048W NEO1 SGTC_2954 9074818 52.69 µM -0.430181105410492 0.340504265795783 no 2250 0.333531952659697 766 16648742 SGTC_2695 st077686 51.995 µM -0.43133547067527 0.340067760676846 no 2251 0.333112231331064 721 2876092 SGTC_1313 1220-0047 237 µM -0.431816722279626 0.339885846185254 no 2252 0.332937312382646 729 3528706 SGTC_1186 1319-0216 26 µM -0.433332265817712 0.339313210082065 no 2253 0.332386700338439 713 4565136 SGTC_2290 7904846 200 µM -0.433373919987177 0.339297476615699 no 2254 0.332371572063794 710 2962154 SGTC_2314 7727897 200 µM -0.434078874764568 0.339031246090097 no 2255 0.332115582721665 707 900724 SGTC_384 k007-0144 5.16 µM -0.43411147283714 0.339018937169719 no 2256 0.332103747318358 715 6824886 SGTC_1024 4507-0395 26 µM -0.434138217400437 0.339008838642694 no 2257 0.332094037277524 704 4201836 SGTC_1675 st018485 24.5 µM -0.435801452003552 0.33838104249253 no 2258 0.33149039513912 736 3323024 SGTC_1751 st044839 27.194 µM -0.436432990421371 0.338142782693002 no 2259 0.331261303724638 731 5291326 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.436742271668933 0.338026124134501 no 2260 0.331149134559703 720 17037758 SGTC_714 4296-0578 26.1 µM -0.438895893305073 0.337214226011855 no 2261 0.330368486264639 733 1589775 SGTC_2183 6420625 130.508 µM -0.439252816707197 0.337079741823184 no 2262 0.33023917925238 714 2897619 SGTC_599 1935-0052 86.5 µM -0.439924281256431 0.336826798975028 no 2263 0.329995974515644 735 9557311 SGTC_3094 9117742 49.47 µM -0.440466909375084 0.336622443123016 no 2264 0.32979948686224 768 17149698 SGTC_2129 girgensonine 121.053 µM -0.441175514861057 0.336355652184666 no 2265 0.329542968893993 747 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2435 5706476 10.6 µM -0.44163351039454 0.336183260057631 no 2266 0.32937721536503 717 5725375 SGTC_424 splitomicin 100 mM -0.441884951168579 0.336088630962057 no 2267 0.329286230486146 753 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_90 0870-0863 4.608 µM -0.442158748389728 0.335985599887813 no 2268 0.32918716733174 764 1738164 SGTC_965 1291-5240 308 µM -0.444025960233733 0.335283288944669 no 2269 0.328511907510257 756 2834598 SGTC_548 1436-0017 110 µM -0.444498843961107 0.335105515266912 no 2270 0.328340982237918 746 9677137 SGTC_2401 5128683 200 µM -0.444680345509033 0.335037292236727 no 2271 0.328275387485835 773 708373 SGTC_3009 9080819 71.4286 µM -0.444847605071411 0.334974427320503 no 2272 0.328214944481704 753 17027216 SGTC_2714 st079313 56.9 µM -0.44541422001516 0.334761498074927 no 2273 0.328010218859802 729 2939799 SGTC_2680 butyl paraben 22.24 µM -0.446871561958452 0.334214085077483 no 2274 0.32748389900076 750 7184 An antifungal and steroid mimetic. SGTC_1778 st046819 58.9 µM -0.446965676008125 0.334178745659381 no 2275 0.327449921428018 743 671715 SGTC_758 0868-0029 16 µM -0.447862535890604 0.333842052443044 no 2276 0.327126203872971 700 762687 SGTC_3307 9126885 69.2785 µM -0.449083763916689 0.333383802137186 no 2277 0.32668561616117 735 24824909 SGTC_1781 st038725 66.3 µM -0.44962131423747 0.333182171946967 no 2278 0.326491758345648 714 4270275 YIL048W NEO1 SGTC_2158 5657123 3.6195 µM -0.449642009467702 0.333174410319411 no 2279 0.326484295920851 786 2858827 SGTC_1902 st060212 70.5 µM -0.45073977675373 0.33276280147347 no 2280 0.326088555235122 715 688944 SGTC_414 piperonyl butoxide 100 µM -0.452572410957113 0.332076102732014 no 2281 0.325428334379974 743 5794 A potent inhibitor of cytochrome P450. SGTC_2219 9098279 200 µM -0.454513631301653 0.33134933072348 no 2282 0.324729591521531 744 902349 SGTC_2054 5233173 129 µM -0.458469178984686 0.329870382744775 no 2283 0.323307700317254 717 6889 SGTC_813 k007-0158 173 µM -0.459161697544345 0.329611728053204 no 2284 0.323059026843259 749 6523916 SGTC_1856 st057054 55.7 µM -0.459245043590192 0.329580603915372 no 2285 0.323029103802831 772 1266018 SGTC_2822 7994718 71.43 µM -0.459447956558888 0.329504834515703 no 2286 0.322956258429336 775 1018011 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.459631176751955 0.329436424576188 no 2287 0.322890488559425 735 676296 Flavone; oxidizing agent. SGTC_1247 0448-0043 5.84 µM -0.459733818866422 0.329398103015302 no 2288 0.32285364592245 757 3089013 YGL099W LSG1 SGTC_2248 tofa 1.1 µM -0.460966001987268 0.32893820588502 no 2289 0.322411498585953 757 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1228 0124-0032 52.5 µM -0.462229922891453 0.328466731935204 no 2290 0.321958223555771 725 X1228 SGTC_2952 9073731 13.78 µM -0.462946535650209 0.328199538762253 no 2291 0.321701345077896 757 16457353 SGTC_2400 5203494 178.7 µM -0.462950734040437 0.32819797362719 no 2292 0.321699840365291 749 6777674 SGTC_1876 myriocin 605 nM -0.463363127132961 0.328044250621271 no 2293 0.321552051999045 790 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_69 0096-0274 206.684 µM -0.463566863419078 0.327968316947162 no 2294 0.32147904991371 767 6741392 SGTC_113 0099-0221 2.5 µM -0.463915584163087 0.327838363242302 no 2295 0.321354113496826 719 89219 SGTC_68 0986-0284 82.829 µM -0.465033775456476 0.327421800544725 no 2296 0.320953634707695 699 423278 YIL048W NEO1 SGTC_2935 9038016 29.96 µM -0.465398498924327 0.327285975595957 no 2297 0.320823054470867 756 6463195 SGTC_3183 9108214 49.47 µM -0.467024907845039 0.326680570838895 no 2298 0.320241028860058 746 4974831 SGTC_2198 6589944 200 µM -0.467078214130439 0.326660736135905 no 2299 0.320221960181259 731 5290268 SGTC_1331 1472-0049 76.2 µM -0.467580718449491 0.326473783696606 no 2300 0.320042228104682 757 24051409 SGTC_1390 3413-2614 145 µM -0.468565785902873 0.326107424243788 no 2301 0.319690018921343 770 3421432 SGTC_357 1325-0123 420 µM -0.468633523975316 0.326082237731048 no 2302 0.31966580525884 766 1098503 SGTC_2549 cedrol 20.94 µM -0.468718164395989 0.326050767666624 no 2303 0.319635550760425 750 6708665 A sedative which affects the nervous system. SGTC_1339 1486-1321 22.7 µM -0.469031389173784 0.325934318673515 no 2304 0.319523599818348 743 3469382 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.469150543082994 0.325890024742197 no 2305 0.319481016852472 716 3256 An antibiotic and ribosome inhibitor. SGTC_720 r052-1644 49.9 µM -0.473118804367018 0.324416281567837 no 2306 0.318064210840312 767 1422863 YOR257W CDC31 SGTC_546 peri-Naphthalide 147 µM -0.473655256009259 0.324217262952819 no 2307 0.317872882647643 741 223824 A penicillin ester. SGTC_2055 5235184 200 µM -0.475004166995931 0.323717051388037 no 2308 0.317392001598816 794 2836034 SGTC_1269 0831-0796 3.05 µM -0.475152010947001 0.323662246312362 no 2309 0.317339314574694 774 927758 SGTC_3010 9080089 71.4286 µM -0.475581831656347 0.323502935466638 no 2310 0.317186160755185 752 17027233 SGTC_967 1306-0166 352 µM -0.475782014673405 0.323428749695051 no 2311 0.317114842177299 753 4437607 SGTC_1146 3579-1023 7 µM -0.478370243511257 0.32247021156729 no 2312 0.316193354403687 763 X1146 SGTC_2130 NSC 7 2.4545 µM -0.478962480607705 0.322251044916857 no 2313 0.315982660209003 756 21448 SGTC_196 k015-0023 18.111 µM -0.479112806957999 0.322195424115228 no 2314 0.315929189632358 736 5211998 SGTC_542 3381-0244 89.3 µM -0.481086985035815 0.321465347404789 no 2315 0.315227338854448 776 1112843 SGTC_1467 k284-1082 293 µM -0.482329076537969 0.321006358808444 no 2316 0.314786097490186 771 3334705 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.483221850521329 0.320676621909799 no 2317 0.314469111106927 749 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3345 9148410 3.559 µM -0.483287073172955 0.320652538134687 no 2318 0.314445958651165 769 4903596 SGTC_889 0919-1524 82.7 µM -0.483799774575316 0.320463246996506 no 2319 0.314263987538828 751 3905452 SGTC_1623 st003709 20.3 µM -0.486480966176587 0.319474103252974 no 2320 0.313313098620782 733 16192618 SGTC_1674 st016616 23.6 µM -0.488452669733552 0.318747521685366 no 2321 0.312614621382374 737 625830 SGTC_341 1486-1430 230 µM -0.48979096910874 0.318254748828193 no 2322 0.31214091091969 770 2054753 YPL210C SRP72 SGTC_2431 5490079 200 µM -0.491859696983726 0.317493658879421 no 2323 0.311409265701508 803 5722345 SGTC_564 3555-0129 330 µM -0.494882816699754 0.316382832704469 no 2324 0.310341420383322 757 563260 SGTC_1458 k015-0034 6.33 µM -0.496684848189862 0.315721474041784 no 2325 0.309705654445319 768 3598957 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.497807288926884 0.315309827982823 no 2326 0.309309938982946 741 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_680 0417-1641 114 µM -0.497859178363607 0.315290803490019 no 2327 0.309291650751903 745 2835990 SGTC_2896 9052656 71.43 µM -0.498215954342675 0.315160010128697 no 2328 0.309165919233245 770 6469436 SGTC_1796 st049173 110.4 µM -0.499144660629921 0.314819656935268 no 2329 0.308838738426485 793 94134 SGTC_704 1310-0270 142 µM -0.49930122481934 0.314762294616956 no 2330 0.308783596200489 785 5718033 SGTC_2327 6189656 200 µM -0.499999611472737 0.314506472689924 no 2331 0.308537675512978 775 5349088 SGTC_578 3460-0051 92 µM -0.500016887321492 0.3145001456029 no 2332 0.308531593310728 793 2876744 SGTC_830 4076-0286 57.8 µM -0.50031859934896 0.314389655721824 no 2333 0.308425379877657 750 6866659 SGTC_3284 9108171 64.8615 µM -0.501557762577939 0.313936036536537 no 2334 0.307989318283765 767 8687505 SGTC_3334 9142812 21.919 µM -0.501809346247175 0.313843973865551 no 2335 0.307900819050747 749 45283678 SGTC_3024 9090631 49.47 µM -0.502625851724174 0.313545267734215 no 2336 0.307613675057681 743 25236383 SGTC_1826 st055655 41.6 µM -0.504563001697727 0.31283708006848 no 2337 0.306932900801223 748 676168 SGTC_2855 9016525 58.44 µM -0.504771150875599 0.312761025442421 no 2338 0.306859790296459 749 43811474 SGTC_3027 9089541 49.47 µM -0.507071345566168 0.311921099666035 no 2339 0.306052379811449 759 9943819 SGTC_2059 5238311 157 µM -0.507136414547241 0.311897353645168 no 2340 0.306029553080745 742 703021 SGTC_1432 4049-0298 68.4 µM -0.507607106978629 0.311725604268519 no 2341 0.305864452762762 776 741646 SGTC_174 3553-0389 74.3 µM -0.507846104450916 0.311638412955645 no 2342 0.305780636983401 740 738071 SGTC_2247 cerulenin 830 nM -0.508312075398098 0.311468447305149 no 2343 0.305617251462626 733 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_911 3456-4043 236 µM -0.508911192248225 0.311249974932563 no 2344 0.305407237248843 756 914281 SGTC_635 k038-0028 24.7 µM -0.509139405894297 0.31116677262388 no 2345 0.305327256151622 781 4035102 SGTC_868 0527-0199 213 µM -0.510648697050833 0.310616757141396 no 2346 0.304798535189158 769 2849450 SGTC_2369 9071472 200 µM -0.512585421640118 0.309911596269435 no 2347 0.304120676520537 749 17296037 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.512929426481598 0.309786417210852 no 2348 0.304000344217629 781 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2048 5246248 200 µM -0.514901916250575 0.309069078979241 no 2349 0.303310780878971 756 677046 SGTC_3330 9141424 71.43 µM -0.516316580059029 0.30855505385955 no 2350 0.302816659028406 747 27261020 SGTC_1344 1488-0097 29.1 µM -0.516865717754255 0.308355622921261 no 2351 0.302624950244318 789 747966 SGTC_200 k038-0079 37.545 µM -0.517207809745025 0.308231413578326 no 2352 0.302505550431241 762 3436683 SGTC_396 dithiazanine 1.25 µM -0.519230166123213 0.307497570074815 no 2353 0.301800122568091 755 10578 An antihelmenthic. SGTC_64 000l-0018 272.079 µM -0.51925575045771 0.307488291325634 no 2354 0.301791203111072 778 6811119 SGTC_2566 crystal violet carbinol 226 nM -0.520944851937673 0.306875972464776 no 2355 0.301202594646654 791 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.521046864990758 0.306839008774422 no 2356 0.30116706228416 774 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_490 phenamil 164 µM -0.521067694183407 0.306831461708859 no 2357 0.301159807460225 771 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_754 3474-0146 171 µM -0.521675540934262 0.306611255958034 no 2358 0.300948128652171 755 24762078 SGTC_3324 9138759 60.749 µM -0.522302161584792 0.306384322010032 no 2359 0.300729982205945 766 45595710 SGTC_1025 k007-0731 70 µM -0.52251837390437 0.306306036810493 no 2360 0.30065472842802 764 6256118 SGTC_824 1304-0008 100 µM -0.523818924992863 0.305835325674432 no 2361 0.30020224458088 755 768245 SGTC_3206 9114350 49.47 µM -0.525962360685062 0.305060247325516 no 2362 0.29945717953914 765 17087243 SGTC_3286 9117135 37.221 µM -0.526387074216018 0.304906772127091 no 2363 0.299309647341423 773 3438150 SGTC_3089 9117425 49.47 µM -0.526851586263404 0.304738954559329 no 2364 0.299148328143994 802 9401657 SGTC_1604 st002052 72.4 µM -0.529251475071137 0.303872584624121 no 2365 0.298315506280989 748 6254834 YHR062C RPP1 SGTC_1947 st076332 61.6 µM -0.534616921901598 0.301939621552346 no 2366 0.296457389911992 781 24208416 SGTC_2167 5876490 200 µM -0.535547506544128 0.301604930761344 no 2367 0.296135658205182 799 686534 SGTC_88 0180-0332 8.668 µM -0.535653215526852 0.301566922398319 no 2368 0.296099121496754 750 3101745 SGTC_2757 clomiphene 4.22 µM -0.54091879738275 0.299676381575679 no 2369 0.294281776964701 810 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_184 1494-0393 24.714 µM -0.54165243741694 0.299413404048143 no 2370 0.294028980448121 784 3090647 SGTC_2066 5222451 176 µM -0.542806886886892 0.298999796967941 no 2371 0.29363138549384 785 2281147 SGTC_567 1080-0542 68.4 µM -0.543417514396887 0.298781131111739 no 2372 0.293421184716208 740 5950415 SGTC_1590 st077108 57.8 µM -0.54397317954405 0.298582210475121 no 2373 0.293229964638872 772 5489485 SGTC_2651 TUB2.036 5 µM -0.545854919876359 0.297909020601324 no 2374 0.292582834097289 771 15992207 YFL037W TUB2 SGTC_1294 1000-1494 117 µM -0.546162423647239 0.297799077386481 no 2375 0.292477146655127 746 712797 YDL207W GLE1 SGTC_197 4544-0043 41.561 µM -0.548615001871992 0.2969228592037 no 2376 0.291634844186032 781 896523 SGTC_409 arachidonic acid 100 µM -0.549323957935749 0.296669794593282 no 2377 0.291391574350263 766 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2673 kobusone 100 µM -0.549691006612207 0.296538813967267 no 2378 0.291265663175141 788 6710676 An epoxy ketone and protein crosslinker. SGTC_1000 4048-0884 8.67 µM -0.549734156156526 0.296523417874607 no 2379 0.291250862965246 789 13040088 SGTC_1281 0884-0031 11.8 µM -0.550114284732121 0.296387800874293 no 2380 0.29112049477358 783 1548255 SGTC_2826 7992541 19.48 µM -0.550508573442184 0.296247162067671 no 2381 0.290985299049646 831 2985066 SGTC_1196 1588-0294 184 µM -0.553701085127985 0.29510955431931 no 2382 0.289891716259282 795 6144269 SGTC_2687 chenodiol 100 µM -0.553818872295873 0.295067620985014 no 2383 0.289851405607617 750 5702181 A cholesterol synthesis inhibitor. SGTC_2269 7935389 174.42 µM -0.554366386178021 0.294872736955373 no 2384 0.289664062833772 763 97605 SGTC_421 streptovitacin 30 mM -0.556910840042337 0.293967834507175 no 2385 0.288794173970206 784 91467 include heat shock SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.560109250438708 0.292832185775577 no 2386 0.28770246058682 804 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1166 k206-0078 225 µM -0.563362500492502 0.291679159072915 no 2387 0.286594033378289 766 5404595 SGTC_2755 lomerizine 42.69 µM -0.565236471770149 0.291015942524785 no 2388 0.28595646626454 782 3949 A calcium channel blocker. SGTC_3267 9137951 49.47 µM -0.565623634045304 0.290879009915567 no 2389 0.28582482904384 798 16643986 SGTC_2323 6148992 148.28 µM -0.567291245896504 0.290289548904569 no 2390 0.285258161819686 783 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_672 1441-0018 53.7 µM -0.567769261636477 0.290120684971074 no 2391 0.285095827188944 756 251141 SGTC_1289 0976-0073 69.1 µM -0.568336841338695 0.289920241454921 no 2392 0.28490313375382 796 3391136 SGTC_1832 st054113 55 µM -0.568465570628676 0.289874789120461 no 2393 0.284859438775936 779 1251267 SGTC_202 3594-0513 34.79 µM -0.568583105738069 0.289833292198304 no 2394 0.284819546265531 788 708429 SGTC_1530 rhein 70.4 µM -0.570026612698554 0.289323875342397 no 2395 0.284329824101657 790 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1730 st033808 45.1 µM -0.570517427759905 0.28915076150451 no 2396 0.284163402594261 798 1045166 SGTC_1565 sinapyl alcohol 95.1 µM -0.570529987406598 0.289146332270158 no 2397 0.284159144584549 793 5280507 A phenol propionate derived from cinnamic acid. SGTC_2655 perillic acid 100 µM -0.570549462415114 0.289139464355282 no 2398 0.284152542168124 791 5702197 An apoptosis inducer. SGTC_1021 4476-0760 85.3 µM -0.5713351055073 0.288862469160692 no 2399 0.283886254678884 772 746768 SGTC_364 0083-0097 67.7 µM -0.571448457684889 0.288822514749952 no 2400 0.28384784472006 793 5207356 SGTC_2654 protoveratrine a 100 µM -0.571616859040235 0.288763161391647 no 2401 0.28379078566265 812 5702278 A heart drug and vasodilator. SGTC_581 0958-0271 211 µM -0.572316376858935 0.288516676579953 no 2402 0.283553828396253 781 4591145 SGTC_1969 st069479 40.1 µM -0.574061866946939 0.287902061657479 no 2403 0.282962968371414 803 3895485 SGTC_1665 st014639 11.4 µM -0.57425741137223 0.287833245873037 no 2404 0.282896812118455 792 981133 YIL048W NEO1 SGTC_2656 pseudo-anisatin 100 µM -0.574464298003347 0.287760447010861 no 2405 0.282826826677268 814 6708809 A neurotoxin. SGTC_1264 0783-0040 158 µM -0.574594818365302 0.287714524237194 no 2406 0.282782678634061 777 2855798 SGTC_861 0443-0273 110 µM -0.575023431777359 0.287563743649375 no 2407 0.282637724978893 789 6149169 SGTC_472 calcifediol 10 µM -0.575251273315662 0.287483607188453 no 2408 0.282560685318593 777 5283731 A vitamin D metabolite. SGTC_952 1185-0122 232 µM -0.575474501551526 0.287405103562266 no 2409 0.282485215338195 787 678600 SGTC_1327 1436-0082 2.18 µM -0.575690888369236 0.287329015566715 no 2410 0.282412067587709 799 15992205 SGTC_991 3996-0057 64.7 µM -0.576170930316436 0.287160252673601 no 2411 0.282249825961424 766 715343 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.576460175196447 0.287058588798063 no 2412 0.282152090415388 783 2724278 An inhibitor of dopamine biosynthesis. SGTC_3087 9117406 49.47 µM -0.576596529912782 0.287010668714481 no 2413 0.282106021948789 769 42546093 SGTC_277 nystatin 15.5 µM -0.577635749635943 0.286645573058818 no 2414 0.281755032781086 799 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_167 3672-0051 66.205 µM -0.57946776916268 0.286002490175079 no 2415 0.281136794155495 777 3237971 SGTC_1035 k081-0041 55.2 µM -0.5798182476573 0.285879541978938 no 2416 0.28101859537317 801 731709 SGTC_2612 dictamnine 15.46 µM -0.580828247369686 0.285525373723663 no 2417 0.280678107596123 772 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1817 st052116 64.4 µM -0.58089683093876 0.285501331664995 no 2418 0.280654994166672 779 4361398 SGTC_3166 9102297 49.47 µM -0.582569326014312 0.284915334881398 no 2419 0.280091629831815 793 25237072 SGTC_3159 9100096 49.47 µM -0.584004541046256 0.284412932417541 no 2420 0.279608628432024 782 25236875 SGTC_423 5-fluorouracil 457 µM -0.584112795034673 0.284375054872589 no 2421 0.279572213481707 795 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2684 capsaicin 100 µM -0.584518017914761 0.284233290758225 no 2422 0.279435923279497 805 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1732 st034308 51.822 µM -0.58520497392827 0.283993041686687 no 2423 0.279204950415347 780 830119 SGTC_1914 st062367 72.6 µM -0.585933610883307 0.28373832177641 no 2424 0.278960064767513 797 978205 SGTC_2127 5253358 187.912 µM -0.588009254387099 0.283013310108652 no 2425 0.278263040571503 788 20612 SGTC_24 0417-1663 219 µM -0.588030518144606 0.283005887390886 no 2426 0.278255904361158 816 4329390 SGTC_2506 ethyl hematommate 54.16 µM -0.588652116708932 0.282788942085614 no 2427 0.278047332593213 789 3940691 An allergen. SGTC_604 1000-0114 314 µM -0.590037128748085 0.282305843900311 no 2428 0.27758287884335 810 1572745 SGTC_3 0833-0587 95.581 µM -0.592398446515866 0.281483122842316 no 2429 0.276791903181992 795 5382644 SGTC_853 0419-0306 21 µM -0.593921841542709 0.280952962126167 no 2430 0.276282194872814 796 762713 SGTC_1750 st081859 2.357 µM -0.596074919572441 0.280204487797528 no 2431 0.275562589085374 801 5291695 SGTC_443 clozapine 122 µM -0.596393056347571 0.280093975908155 no 2432 0.275456339024508 807 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3116 9124943 49.47 µM -0.597432371648001 0.279733093905898 no 2433 0.275109373141898 771 41905195 YPL160W CDC60 SGTC_1215 3852-0577 11.2 µM -0.599281981022432 0.279091411642044 no 2434 0.274492430863888 778 2884876 SGTC_258 haloperidol 50.781 µM -0.599467154713018 0.279027209040629 no 2435 0.274430703287 814 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3317 9138495 8.753 µM -0.599594166718784 0.278983176154258 no 2436 0.274388367846364 812 17020139 SGTC_2433 5607874 27.82 µM -0.601125606188541 0.278452518558853 no 2437 0.273878164783141 790 2252428 SGTC_320 4092-0846 5.34 µM -0.601932606360713 0.278173083718381 no 2438 0.273609499394139 798 1359356 SGTC_1364 1653-0028 37.6 µM -0.60267479483886 0.277916211594025 no 2439 0.273362526200521 786 5718652 SGTC_779 1360-0071 233 µM -0.605842220009998 0.2768212659596 no 2440 0.272309765409325 803 7566 SGTC_2878 9043973 25.97 µM -0.606469841353938 0.276604554935174 no 2441 0.272101401540903 801 6465167 SGTC_2641 levomentholum 100 µM -0.607033690157583 0.276409934831925 no 2442 0.271914277120994 797 16666 SGTC_2140 5586273 200 µM -0.607078330033746 0.276394529639412 no 2443 0.27189946522693 803 854421 SGTC_2865 9030313 51.95 µM -0.608540743086241 0.275890084839018 no 2444 0.271414446103316 806 42562754 SGTC_3041 9091929 49.47 µM -0.610797990008996 0.275112358923492 no 2445 0.270666662123618 805 25236887 SGTC_1168 k815-0004 80.5 µM -0.611022373463054 0.275035107489276 no 2446 0.270592384311822 805 642433 SGTC_317 4495-0002 170 µM -0.613866956105748 0.274056693137933 no 2447 0.269651623746958 803 15991618 SGTC_3208 9114115 49.47 µM -0.61461465969612 0.273799800933732 no 2448 0.269404615383273 810 650895 SGTC_2096 5468907 200 µM -0.61545315996971 0.273511854989307 no 2449 0.269127746790029 793 759785 SGTC_126 0417-1624 672.48 µM -0.61569281354148 0.27342958408857 no 2450 0.269048640622431 826 41912 YDL195W SEC31 SGTC_940 3232-1287 54.8 µM -0.615918473131856 0.273352128396336 no 2451 0.268974164334138 813 1585493 YIL048W NEO1 SGTC_3105 9121040 49.47 µM -0.616361303214211 0.273200162411065 no 2452 0.268828043572253 769 41448907 SGTC_1271 0832-2808 169 µM -0.616834816721524 0.27303771311794 no 2453 0.268671842310374 816 3663794 SGTC_1786 berberine 21.6 µM -0.620116202843949 0.271913278337012 no 2454 0.267590642734563 813 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3235 9132602 49.47 µM -0.622369249181731 0.271142561535145 no 2455 0.2668495479126 806 4912240 SGTC_504 lovastatin 124 µM -0.623276691929554 0.270832453661672 no 2456 0.266551355876375 823 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3215 9129942 49.47 µM -0.62339459713342 0.270792173945425 no 2457 0.266512623775039 822 17682944 SGTC_2662 daunorubicin 22.37 µM -0.624171387902328 0.270526875261365 no 2458 0.266257517589087 781 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2461 5755302 26.15 µM -0.626654570179829 0.269679661753605 no 2459 0.265442844588714 835 2788904 SGTC_841 0251-0215 91.2 µM -0.63050944749634 0.268367090966769 no 2460 0.264180661788367 811 3888614 SGTC_2767 sibutramine 71.45 µM -0.631540217497228 0.268016662991262 no 2461 0.26384368075561 813 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2335 9018011 154.17 µM -0.63301515867163 0.267515632388851 no 2462 0.263361872000743 790 6458208 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.633064608929626 0.267498842554185 no 2463 0.263345726216228 816 616764 SGTC_147 4466-0538 29.23 µM -0.634465776095993 0.2670233255385 no 2464 0.262888447486538 815 6742687 YHR072W ERG7 SGTC_533 1222-0222 6.71 µM -0.634985408658123 0.266847085326926 no 2465 0.262718965758506 818 3982874 SGTC_3071 9117417 49.47 µM -0.63593295596294 0.266525863579394 no 2466 0.262410060655432 806 45595590 YGL055W OLE1 SGTC_943 3253-1379 105 µM -0.636414849330504 0.266362575147021 no 2467 0.262253032408758 824 668464 SGTC_1887 st057648 70.8 µM -0.636988870842797 0.266168135394031 no 2468 0.262066046417162 825 688672 SGTC_2823 7987624 58.44 µM -0.638318876499683 0.265717895549154 no 2469 0.261633063330567 844 2239440 SGTC_2967 9089538 49.85 µM -0.638390570704987 0.265693636258311 no 2470 0.261609733728812 830 728216 SGTC_2515 chrysin 20.77 µM -0.64100326532142 0.264810341131912 no 2471 0.260760280728632 797 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2667 digitoxin 100 µM -0.641537496596638 0.264629913186182 no 2472 0.260586763576526 793 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2315 7733312 200 µM -0.642565422655074 0.264282923836175 no 2473 0.260253062731398 807 726316 SGTC_2889 9059656 51.95 µM -0.642610006366301 0.264267879288174 no 2474 0.260238594279404 827 3949838 SGTC_1687 st020778 55.3625 µM -0.643522456015925 0.263960073589693 no 2475 0.259942574207344 794 4259299 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.643635993015343 0.263921785813569 no 2476 0.259905752294442 821 2374 Ca(2+)-ATPase inhibitor. SGTC_1870 st057514 26.5 µM -0.643910740608393 0.263829145139164 no 2477 0.259816658273805 813 5393161 SGTC_1 0258-0098 57.368 µM -0.64763344581912 0.262575542478445 no 2478 0.258611029851659 793 6790032 YDR047W HEM12 SGTC_1816 st051957 91.6 µM -0.648253043548319 0.262367192297248 no 2479 0.258410649628614 828 674121 SGTC_790 1575-0012 79.1 µM -0.64854919271256 0.262267637060558 no 2480 0.258314902300743 826 378741 YLR208W SEC13 SGTC_19 0279-0214 38.434 µM -0.650005745074525 0.261778275682112 no 2481 0.257844255309053 822 3566274 YBR002C RER2 SGTC_1373 2887-0003 58.5 µM -0.65029971322593 0.261679567338359 no 2482 0.257749321147789 823 776948 SGTC_1400 3771-8998 51.5 µM -0.65068620489296 0.261549820605397 no 2483 0.257624535028509 800 670767 SGTC_577 r071-0003 38.6 µM -0.652422337225305 0.260967401959704 no 2484 0.257064379188313 839 4568517 YMR134W ERG29 SGTC_2675 theaflavin digallate 100 µM -0.653493141385402 0.260608513122944 no 2485 0.256719204810801 822 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1042 0350-0096 82 µM -0.653604967266336 0.260571048414471 no 2486 0.256683171590093 820 3122515 SGTC_10 0279-0212 42.575 µM -0.65488521597471 0.260142327983795 no 2487 0.256270829735593 809 39851 YBR002C RER2 SGTC_1150 3909-7983 10.9 µM -0.655301104671022 0.260003136468138 no 2488 0.256136954859148 826 23965914 SGTC_2915 7971052 15.16 µM -0.655396996826363 0.259971048295914 no 2489 0.256106092278878 802 5741558 SGTC_968 1309-0633 340 µM -0.655953981218989 0.259784706277081 no 2490 0.255926867009082 830 3761976 SGTC_632 0781-2353 4.65 µM -0.656889727213237 0.259471802830165 no 2491 0.255625912028717 829 6811515 YHR007C ERG11 SGTC_3261 9137475 49.47 µM -0.65790859944488 0.259131324352745 no 2492 0.25529843226873 772 17027690 SGTC_1220 1838-0075 193 µM -0.659171786701856 0.258709523585968 no 2493 0.25489273095386 804 5529645 SGTC_1126 isoteolin 1.0172 µM -0.660404319043439 0.258298301873575 no 2494 0.254497200636557 817 133323 SGTC_2832 7992762 51.95 µM -0.661334640104981 0.257988134333723 no 2495 0.254198865651528 808 2985177 SGTC_2603 homopterocarpin 100 µM -0.662683649185835 0.257538720310907 no 2496 0.253766591949068 822 101795 A weak amylase inhibitor. SGTC_576 1073-0113 22.7 µM -0.662968904550988 0.257443741360641 no 2497 0.253675234764786 846 5439563 SGTC_616 4092-0450 108 µM -0.665353563902101 0.256650455010792 no 2498 0.252912189140629 845 787165 SGTC_3195 9113082 49.47 µM -0.666334374876499 0.256324545963538 no 2499 0.252598699253043 818 17018038 SGTC_1828 st055811 49 µM -0.66732447537301 0.255995769061145 no 2500 0.252282447952441 831 5877589 SGTC_2545 solidagenone 89.61 µM -0.668437764259986 0.255626348650027 no 2501 0.25192709813067 778 6708572 An anti ulcer agent SGTC_245 methotrexate 289.6 µM -0.668711729519625 0.255535482015572 no 2502 0.251839691890522 797 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2318 6029776 164 µM -0.669213548154144 0.255369086542173 no 2503 0.251679632534191 839 818325 SGTC_2978 9011784 42.97 µM -0.66944203095951 0.255293343863746 no 2504 0.251606773788352 806 2994934 SGTC_2430 5571206 200 µM -0.669471642900558 0.255283528283564 no 2505 0.251597331928941 833 1731771 SGTC_1397 3532-0190 20.1 µM -0.672717619483381 0.254208769642646 no 2506 0.250563478020434 798 5322280 SGTC_687 k029-0044 34.9 µM -0.67280095971002 0.254181206563413 no 2507 0.250536963559462 812 5829338 SGTC_199 4063-0024 41.6 µM -0.672915688897245 0.254143264790047 no 2508 0.250500465220132 813 306215 SGTC_2212 7123476 200 µM -0.673652099310022 0.253899799272487 no 2509 0.250266261006457 805 1085715 SGTC_2267 7931562 200 µM -0.673823199949718 0.253843249017657 no 2510 0.250211861658077 809 934880 SGTC_2466 5983409 37.09 µM -0.67402866664367 0.25377534921978 no 2511 0.250146544331993 820 2879657 SGTC_2206 7254556 146.969 µM -0.674535681025248 0.253607838909137 no 2512 0.249985404484617 807 4398905 SGTC_429 1112-0049 25.5 µM -0.674884405589552 0.253492659013629 no 2513 0.249874604455251 814 2836170 SGTC_1051 3253-3903 78 µM -0.675107960480045 0.253418835748207 no 2514 0.249803588219671 828 5509239 SGTC_2994 9053520 71.4286 µM -0.676841784436744 0.252846668741216 no 2515 0.24925317185832 822 4647384 SGTC_1761 st044296 37 µM -0.677345068576703 0.252680710932753 no 2516 0.24909352110972 835 1826700 SGTC_916 4466-0038 42 nM -0.678394683322111 0.252334785420353 no 2517 0.248760739607773 836 5722064 YGL116W CDC20 SGTC_497 capsazepine 133 µM -0.679293260433608 0.252038836427596 no 2518 0.248476032942778 820 2733484 A calcium channel blocker. SGTC_1295 1013-0063 9.78 µM -0.679954376195427 0.251821213015073 no 2519 0.248266674850578 828 6826038 SGTC_2764 methyldopa 94.69 µM -0.680024303475428 0.251798200438582 no 2520 0.248244536209197 836 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1644 st010134 20.9 µM -0.68084922683546 0.251526807786902 no 2521 0.247983448907418 839 3818134 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.681492606031705 0.251315248921253 no 2522 0.247779921875906 849 229346 A bile salt which induces apoptosis. SGTC_1993 st073995 70.8 µM -0.681611605621612 0.251276129248115 no 2523 0.247742287236882 837 3098394 SGTC_1466 k213-0079 57.5 µM -0.682849211513305 0.250869472249508 no 2524 0.247351064785598 851 3657981 SGTC_2537 larixol 68.93 µM -0.68374185050539 0.250576382109525 no 2525 0.247069095741361 833 6708759 SGTC_44 0929-0055 61.211 µM -0.684231043054755 0.250415837033129 no 2526 0.246914641341653 822 1379590 SGTC_476 mead acid 10 µM -0.688225425049856 0.249106988111548 no 2527 0.245655417675484 844 5312531 An omega 9 fatty acid. SGTC_1912 st060209 90.8 µM -0.689329313410966 0.248745917188612 no 2528 0.245308027557601 847 688787 SGTC_3180 9109287 49.47 µM -0.68970335608233 0.248623634787039 no 2529 0.245190377458059 824 18891271 SGTC_61 0978-8327 98.565 µM -0.691812765626646 0.247934624420299 no 2530 0.244527459412493 843 6150059 YHR072W ERG7 SGTC_775 4577-0580 57.3 µM -0.692832672156792 0.247601851449397 no 2531 0.244207282935094 835 2006902 SGTC_382 3229-0966 23.2 µM -0.69292307253846 0.247572367316842 no 2532 0.244178914698683 840 5722370 SGTC_537 1334-0398 209 µM -0.693853870624231 0.247268896134071 no 2533 0.243886927477957 842 5846986 SGTC_2859 9028643 45.46 µM -0.695143706614739 0.24684869561577 no 2534 0.243482623305277 805 17151580 SGTC_148 3253-0744 288.01 µM -0.697092557382835 0.246214528171802 no 2535 0.242872435805567 832 6893655 SGTC_331 k048-0133 24.5 µM -0.697505960108639 0.246080116905843 no 2536 0.24274310537898 826 6813582 SGTC_263 alizarin 107.927 µM -0.698266410335212 0.245832971538964 no 2537 0.24250530072574 857 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_272 doxorubicin 8.13 µM -0.69840604997391 0.245787603315507 no 2538 0.242461646948377 842 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2947 9072639 7.68 µM -0.698552817358145 0.24573992416819 no 2539 0.242415769502551 859 16488146 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.700315648472213 0.245167635535815 no 2540 0.241865100635781 835 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1950 st077106 7.18 µM -0.700864526160318 0.244989593332067 no 2541 0.241693782229258 823 13831864 SGTC_60 0986-0278 202 µM -0.701674709992125 0.244726917117108 no 2542 0.241441024082706 862 3110598 SGTC_3127 9126946 49.47 µM -0.702074616224412 0.24459731621829 no 2543 0.241316315766221 818 27243249 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.702677049667753 0.244402150467906 no 2544 0.241128516671643 833 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1846 st056244 14.8 µM -0.702774060213689 0.244370730550339 no 2545 0.241098282597918 845 5393182 SGTC_2033 5192550 145 µM -0.705641650589742 0.243442955138517 no 2546 0.240205507849049 818 182073 SGTC_2775 cyproheptadine 69.59 µM -0.706247938195588 0.243247041853359 no 2547 0.24001698166525 834 2913 A selective serotonin reuptake inhibitor. SGTC_1933 st074711 15.9 µM -0.706770203415717 0.243078347567985 no 2548 0.239854647092252 843 17250958 SGTC_2302 7771753 200 µM -0.706810250648054 0.243065414723339 no 2549 0.239842201770117 830 2203047 SGTC_1588 farnesol 29.9 µM -0.707789258821988 0.242749369808848 no 2550 0.239538068812286 837 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1115 galangin 695.678 nM -0.708211045449014 0.242613276595319 no 2551 0.239407103968597 857 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1362 1611-0397 101 µM -0.709424383389847 0.242222012766109 no 2552 0.239030580405646 840 27816 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.711803717810929 0.241455745270598 no 2553 0.23829316508798 861 91467 include heat shock SGTC_833 3852-0053 558 µM -0.712055011498153 0.241374892782557 no 2554 0.238215355701004 860 3123681 SGTC_454 lyso-paf C-16 6.67 µM -0.712757639003846 0.241148903972969 no 2555 0.237997871337058 854 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2502 avocadyne acetate 18.59 µM -0.714462537824491 0.240601029221028 no 2556 0.237470606598062 822 3952079 SGTC_1694 st024011 44.9 µM -0.715274254400716 0.240340419786987 no 2557 0.237219796950125 852 2787533 SGTC_2741 miltefosine 3.04 µM -0.715292927588084 0.240334426390207 no 2558 0.237214028895771 816 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2852 9023854 51.95 µM -0.715689189575827 0.240207260269246 no 2559 0.237091643712155 854 19798528 SGTC_1100 amiodarone 5.07 µM -0.717502120577663 0.239625932795867 no 2560 0.236532164212666 815 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_291 SEC14.278 35.5 µM -0.719584312794822 0.238959213611061 no 2561 0.235890486757902 844 1068044 SGTC_1575 cyproterone acetate 48 µM -0.719610646157861 0.238950788152628 no 2562 0.235882377649756 854 9880 An androgen receptor antagonist and liver toxin. SGTC_1022 4477-0945 21.3 µM -0.720358243819406 0.238711659252161 no 2563 0.235652226192343 823 4648966 SGTC_1455 4262-0120 131 µM -0.722927015399594 0.237891002801572 no 2564 0.234862362513728 851 1529587 SGTC_1437 4092-1038 11.6 µM -0.723069509276857 0.23784552500475 no 2565 0.234818590386291 842 3977136 SGTC_1258 0671-0043 57.1 µM -0.72335459183599 0.237754553466615 no 2566 0.234731030545915 862 4298767 SGTC_401 neomycin 50 µM -0.723829006766195 0.237603207161948 no 2567 0.23458535946128 826 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2305 7443522 69.23 µM -0.723947359908905 0.237565458769385 no 2568 0.234549026429078 834 5415886 SGTC_1610 st001799 48.1 µM -0.724386899245477 0.237425297781839 no 2569 0.234414120237012 848 621897 SGTC_390 dec-rvkr-cmk 16.7 µM -0.724398082167568 0.237421732346563 no 2570 0.234410688464044 831 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_606 k015-0008 38.6 µM -0.72543101340787 0.237092531119998 no 2571 0.234093826321193 858 1970475 SGTC_2746 daunorubicin 9.88 µM -0.726580825672726 0.236726374414524 no 2572 0.233741388891098 806 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_565 1418-0001 44.5 µM -0.726746291830089 0.236673707473492 no 2573 0.233690694859226 859 2862145 SGTC_1147 3809-1045 12.3 µM -0.728052263784609 0.236258250275397 no 2574 0.233290796899481 834 325925 SGTC_365 0121-0052 13.6 µM -0.728514374943999 0.236111339231365 no 2575 0.233149386169726 812 3101739 SGTC_2162 5663267 200 µM -0.734539925909141 0.234200353069253 no 2576 0.231309867951659 852 6456493 SGTC_1346 1488-2224 62.4 µM -0.735807646112846 0.233799392350195 no 2577 0.230923883673177 841 3722427 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.736237280784327 0.233663591770119 no 2578 0.230793153928269 844 688662 SGTC_2623 humulene 100 µM -0.736922528734982 0.233447086488294 no 2579 0.230584731437685 848 6187145 An anti-inflammatory. SGTC_2030 5175110 200 µM -0.737906207742056 0.23313648601863 no 2580 0.230285723205719 861 2831986 SGTC_745 0469-0705 296 µM -0.739594003785828 0.232604092790306 no 2581 0.229773190567045 870 3486736 SGTC_1755 st041960 45.185 µM -0.7397619220412 0.232551162160878 no 2582 0.229722233828564 861 2257073 SGTC_1231 0242-0792 125 µM -0.740758309696119 0.23223722199107 no 2583 0.229419998689028 852 3707635 SGTC_3016 9080866 49.47 µM -0.740846619346822 0.232209408914517 no 2584 0.229393222401101 841 17066299 SGTC_2968 9090663 33.37 µM -0.740889658092697 0.232195854556732 no 2585 0.22938017329747 869 25236811 SGTC_274 sirtinol 40.1 µM -0.741140508662431 0.232116861984537 no 2586 0.229304125108035 834 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_964 1287-0107 19.4 µM -0.744392154960136 0.231094276818154 no 2587 0.228319631842395 853 51516812 YPR165W RHO1 SGTC_1307 1187-1599 12.2 µM -0.744400091852357 0.231091783885861 no 2588 0.228317231718249 861 1538471 SGTC_1606 st000094 49.2 µM -0.744766251401489 0.230976791592033 no 2589 0.22820652012294 835 1242210 SGTC_3202 9113761 49.47 µM -0.74669545556673 0.230371453434174 no 2590 0.227623706766198 852 4798415 SGTC_2045 5106652 78.05 µM -0.746888990072796 0.230310775925387 no 2591 0.227565286200712 842 673349 SGTC_1985 st071382 65.5 µM -0.747082479332617 0.230250121537309 no 2592 0.227506887734365 863 6123237 SGTC_1574 spiramycin 23.7 µM -0.747222124667115 0.230206351520276 no 2593 0.22746474555735 864 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1127 asiatic acid 681.4 nM -0.748910883991284 0.229677400451112 no 2594 0.226955459897138 866 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1943 st076331 65.2 µM -0.75062839570849 0.229140142528501 no 2595 0.226438163504844 856 24208415 SGTC_1368 1852-0141 284 µM -0.75164335039511 0.228822984367582 no 2596 0.226132783125502 862 2838987 SGTC_3063 1327-0034 4 µM -0.751865764768227 0.228753516132054 no 2597 0.226065894013999 848 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_791 1348-1292 225 µM -0.752109456723577 0.228677415715828 no 2598 0.225992618702917 868 5437054 SGTC_3128 9127691 49.47 µM -0.752476086882788 0.228562950796758 no 2599 0.225882402616977 853 41316314 SGTC_1983 st071813 46.9 µM -0.753014934801731 0.228394776514703 no 2600 0.225720469735662 855 11838595 SGTC_3249 9135183 49.47 µM -0.754088602432041 0.228059892544409 no 2601 0.225398010389386 831 4902779 SGTC_2391 6285546 200 µM -0.754145956913827 0.228042011078946 no 2602 0.225380792205647 851 846083 SGTC_3034 9090421 49.47 µM -0.756140705661564 0.227420597051894 no 2603 0.22478241935809 833 17173761 SGTC_1180 1193-0155 285 µM -0.761642790950408 0.225711513675292 no 2604 0.22313661414968 863 2921347 SGTC_2738 aclarubicin 5.55 µM -0.761686818465357 0.225697867011804 no 2605 0.223123472197002 827 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_559 1550-0661 158 µM -0.762189501800856 0.225542089577954 no 2606 0.22297345543979 868 5830875 SGTC_3112 9123419 49.47 µM -0.763687038318746 0.22507837616459 no 2607 0.222526883395194 891 17015854 SGTC_3231 9132313 49.47 µM -0.763747250222579 0.225059742802785 no 2608 0.222508938609192 867 4905967 SGTC_3190 9110366 49.47 µM -0.76379866677012 0.225043831971033 no 2609 0.222493615731923 841 17123768 SGTC_2089 5281248 129.67 µM -0.764014648958997 0.224977003324798 no 2610 0.222429256478606 855 2737878 SGTC_212 3807-4682 38.772 µM -0.766034153698518 0.224352677952317 no 2611 0.221827990250972 855 3125501 YBL034C STU1 SGTC_301 4119-0100 24.5 µM -0.769465570558722 0.223294121601993 no 2612 0.220808487922839 873 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3287 9117173 37.0625 µM -0.769696506720254 0.223222982437833 no 2613 0.220739971374773 823 2789709 SGTC_583 1488-1091 88.9 µM -0.769701237940889 0.223221525134949 no 2614 0.220738567794204 885 4303273 SGTC_3292 9120825 59.784 µM -0.770522502166162 0.222968642737373 no 2615 0.220495006118126 850 24824900 SGTC_2848 9016370 25.97 µM -0.770843591218647 0.222869817885371 no 2616 0.220399822886057 832 7894410 SGTC_2883 9059145 45.46 µM -0.772506308641412 0.222358465765432 no 2617 0.219907305948691 880 16476510 SGTC_1866 st057638 64 µM -0.773860893534139 0.221942371903667 no 2618 0.21950652888184 847 688802 SGTC_2607 solasodine 47.35 µM -0.776907824703773 0.221008059158941 no 2619 0.218606577222954 878 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_825 1988-2224 89.6 µM -0.777443888109244 0.220843913541764 no 2620 0.218448463782332 863 1180859 SGTC_582 0987-0078 156 µM -0.777953886266796 0.22068781406442 no 2621 0.218298099515457 882 1625765 SGTC_1280 0880-0253 10.1 µM -0.778099353770505 0.220643301173987 no 2622 0.218255221832698 863 6836607 SGTC_2298 7976326 193.81 µM -0.778692420490145 0.220461876670678 no 2623 0.218080461014278 856 2235818 SGTC_1309 pyrazolanthrone 13.4 µM -0.780211465395531 0.219997577146977 no 2624 0.217633207389025 878 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3096 9117468 49.47 µM -0.780236054362138 0.219990066090643 no 2625 0.21762597199558 853 41316311 SGTC_178 4092-0806 87.505 µM -0.780683841608715 0.219853308723949 no 2626 0.217494233242006 838 2169044 SGTC_891 0929-0073 133 µM -0.781201426630382 0.219695295440103 no 2627 0.217342017393685 879 5603632 SGTC_1567 st069303 68.4 µM -0.78213404890689 0.219410740297017 no 2628 0.217067899167128 871 5581319 SGTC_2773 thioridazine 9.09 µM -0.783412377329553 0.219021049999518 no 2629 0.216692495057095 871 5452 An antipsychotic. SGTC_2339 9000433 200 µM -0.784209484956453 0.218778258425652 no 2630 0.216458600271883 865 2988954 SGTC_135 0933-0004 26.348 µM -0.784237134776593 0.218769839327742 no 2631 0.216450489625313 843 21230617 YGL099W LSG1 SGTC_2556 citropten 84.59 µM -0.78469809502504 0.218629508938131 no 2632 0.216315299982497 833 2775 A potential DNA crosslinker. SGTC_920 mycophenolic acid 780.421 nM -0.785079349537435 0.218513482573783 no 2633 0.216203523244068 868 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1351 1496-0003 46.5 µM -0.786126904517484 0.218194865036662 no 2634 0.215896571837571 870 3891978 SGTC_1149 3909-7961 23.3 µM -0.786708929956862 0.218017955707083 no 2635 0.21572613768023 862 735261 SGTC_2853 9015042 58.44 µM -0.788312352172398 0.217531016016702 no 2636 0.215257012130164 852 6457456 SGTC_671 0560-0003 407 µM -0.789685146752209 0.217114614360327 no 2637 0.214855833935516 849 3238678 SGTC_3285 9112818 20.8695 µM -0.794855029939941 0.215550603178099 no 2638 0.213348917903066 870 17017947 YPR165W RHO1 SGTC_1625 st003711 30.1 µM -0.795338616768219 0.215404641724302 no 2639 0.213208277983008 885 24207034 YER133W GLC7 SGTC_1338 1486-1223 76 µM -0.795358844123784 0.215398537732744 no 2640 0.213202396507958 872 3444526 SGTC_1002 4049-0206 172 µM -0.795740534826456 0.215283374074448 no 2641 0.2130914306673 863 4662749 SGTC_3048 9093155 49.47 µM -0.795882319095751 0.215240604050533 no 2642 0.213050219460671 833 25236002 SGTC_652 0437-0092 114 µM -0.796420387942817 0.215078337425441 no 2643 0.21289386595681 860 3091274 SGTC_380 3970-0968 6 µM -0.797303846568243 0.214812064933968 no 2644 0.212637293451016 858 2891601 SGTC_3020 9089140 49.47 µM -0.798432171919013 0.21447226880056 no 2645 0.212309869902089 881 17217859 SGTC_1940 st075990 51.1 µM -0.801535623413261 0.213539275283509 no 2646 0.211410814768378 899 1084979 SGTC_1651 st011928 86.1 µM -0.801951509773914 0.213414426936312 no 2647 0.211290504119024 885 720198 SGTC_2627 acetyl isogambogic acid 100 µM -0.802337732624047 0.213298521635664 no 2648 0.211178810675994 886 6857789 A caspase activator and apoptosis inducer. SGTC_2993 9054257 71.4286 µM -0.804200531227473 0.21274001226996 no 2649 0.210640586031549 863 6470217 YGL055W OLE1 SGTC_1734 st037168 69.4 µM -0.804394035805553 0.212682044192007 no 2650 0.210584722287848 890 708907 SGTC_84 0443-0269 128.823 µM -0.805031399771095 0.212491174592531 no 2651 0.21040078018519 853 6150058 SGTC_2679 rapamycin 1 nM -0.806490991817285 0.212054451809412 no 2652 0.20997990002477 843 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1769 st044406 64.4 µM -0.808250731853585 0.21152862061742 no 2653 0.209473129170187 898 670903 SGTC_1971 st069429 63.5 µM -0.80946315942508 0.211166777497017 no 2654 0.209124392694657 869 1246522 YGL099W LSG1 SGTC_1031 k035-0009 16 µM -0.810959060889315 0.210720833186768 no 2655 0.208694590666316 889 5180959 SGTC_661 1304-0007 33.6 µM -0.811216988904211 0.210643997949655 no 2656 0.208620535514699 868 3117130 SGTC_786 4544-0069 423 µM -0.811345919166155 0.21060559654652 no 2657 0.208583523435625 872 748821 YLR208W SEC13 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.812963138537937 0.210124262743546 no 2658 0.208119596322261 879 641818 YHR062C RPP1 SGTC_1201 1889-3372 45.9 µM -0.814615472641217 0.209633145780953 no 2659 0.20764622548769 856 5392199 SGTC_455 paf C-16 10 µM -0.815660326824323 0.209322936473882 no 2660 0.207347217833994 873 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3171 9103192 49.47 µM -0.818748751721026 0.208407587381516 no 2661 0.206464887774573 883 13018434 SGTC_2737 bleomycin 30.5 nM -0.819548864438413 0.208170835117437 no 2662 0.206236667406774 874 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1573 oleylamine 1.06 µM -0.819898996884057 0.20806728134649 no 2663 0.206136844338374 880 5356789 An amine of the fatty acid oleic acid. SGTC_3349 9149703 23.001 µM -0.820049714609705 0.20802271503792 no 2664 0.206093883403337 867 4910494 SGTC_2131 toluylene red 5.2905 µM -0.82194447771655 0.207462926065984 no 2665 0.205554248717885 858 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1988 st071872 53.4 µM -0.823499160059982 0.207004276310288 no 2666 0.205112097316007 865 16414116 SGTC_552 k242-0005 476 µM -0.823995199840824 0.206858065032184 no 2667 0.204971142711868 893 4088318 SGTC_1213 1315-0166 115 µM -0.824322992302479 0.206761479409264 no 2668 0.204878028853598 870 768401 SGTC_2070 5230947 200 µM -0.825885838498712 0.206301346521676 no 2669 0.204434427321696 894 2835538 SGTC_1097 itavastatin 7.23 µM -0.826178725639403 0.206215182318543 no 2670 0.204351357278187 868 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3194 9111903 49.47 µM -0.826566662628496 0.206101088333622 no 2671 0.204241359685907 889 17087251 SGTC_2226 7298446 200 µM -0.828361077292758 0.205573830229988 no 2672 0.203733021293877 877 3283010 SGTC_1249 0481-0015 10.2 µM -0.833111287933155 0.204181933247004 no 2673 0.202390983990105 881 4227577 SGTC_797 k781-0471 270 µM -0.833982963746519 0.203927127425502 no 2674 0.202145292011286 871 23738129 SGTC_1812 st052057 4.327 µM -0.835701281307207 0.203425388949779 no 2675 0.201661487136846 890 3645418 SGTC_2670 beta-carotene 100 µM -0.837004917274961 0.203045226808121 no 2676 0.201294902022541 839 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3232 9132874 49.47 µM -0.837712221843675 0.202839142558655 no 2677 0.201096173807643 861 3784940 SGTC_42 0133-0086 60.653 µM -0.839040799158928 0.202452378735239 no 2678 0.200723207600087 908 162923 Model of phenazepam hydroxylation. SGTC_3260 9137109 49.47 µM -0.841308278129111 0.201793309429695 no 2679 0.200087627145167 850 17478346 SGTC_3229 9132204 49.47 µM -0.842010404681007 0.201589488929423 no 2680 0.19989106475297 898 17682924 SGTC_1638 st008370 60.6 µM -0.843025027723851 0.201295171723909 no 2681 0.199607223293942 861 24207134 SGTC_1984 st072354 53.1 µM -0.846072950835345 0.200412594630594 no 2682 0.198756024630178 882 5762938 SGTC_339 3091-4833 71.4 µM -0.846781870853038 0.200207648673192 no 2683 0.198558357493112 884 3240077 SGTC_1086 cerivastatin 2.18 µM -0.848477992425678 0.199717818097863 no 2684 0.19808591185991 848 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1145 3546-0597 10.2 µM -0.849999227754237 0.199279107611787 no 2685 0.197662757795413 873 875334 SGTC_474 dl-dihydrosphingosine 5 µM -0.852081976315396 0.198679403893715 no 2686 0.197084297397481 850 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1554 st069299 38.7 µM -0.853707853149721 0.198212008435664 no 2687 0.196633440896795 862 24207999 SGTC_1995 st072814 61.1 µM -0.853794703938849 0.198187059880439 no 2688 0.196609374719509 891 5769371 SGTC_2748 diazoxide 86.69 µM -0.853913573260354 0.198152916829272 no 2689 0.196576439164528 826 3019 A potassium channel activatior. SGTC_953 1188-0045 9.7 µM -0.854969387664714 0.197849809219935 no 2690 0.196284047556291 891 6144426 SGTC_295 k015-0027 31 µM -0.856399804575313 0.197439606268264 no 2691 0.195888336374368 892 3887424 SGTC_2844 9010103 25.97 µM -0.856913234841891 0.197292494563502 no 2692 0.195746418933327 888 2480525 SGTC_796 1234-0020 70.7 µM -0.858648052259722 0.196795913012362 no 2693 0.195267359307436 856 46495034 SGTC_94 0334-0113 514.748 µM -0.859224984091521 0.196630937434687 no 2694 0.195108200958946 889 6795178 SGTC_3066 9117245 49.47 µM -0.859462109449655 0.196563154950239 no 2695 0.195042807990336 875 17176980 SGTC_1845 st056753 3.01 µM -0.861298982184839 0.196038563061162 no 2696 0.194536698063367 881 5375839 SGTC_2201 6605497 169.863 µM -0.861348919631654 0.196024313309735 no 2697 0.194522950066225 891 670741 SGTC_460 trequinsin 123 µM -0.863782456610004 0.195330660192269 no 2698 0.193853703437384 924 5537 A vasodilator. SGTC_717 1532-0246 73.2 µM -0.86618574746676 0.194647093981936 no 2699 0.193194154003976 894 9561992 SGTC_3354 9151612 71.43 µM -0.867140184633187 0.194376028432323 no 2700 0.192932602578162 875 27261949 SGTC_1479 0549-0158 134 µM -0.869214730044658 0.19378763898544 no 2701 0.192364846036062 906 5440202 SGTC_575 k072-0246 11.9 µM -0.86930998424223 0.193760648771195 no 2702 0.192338801655542 898 6796779 SGTC_3131 9127911 49.47 µM -0.869463475863521 0.193717161843268 no 2703 0.192296838549508 875 45595681 SGTC_1276 0871-0068 94.2 µM -0.869876896177314 0.193600062059408 no 2704 0.192183841338934 890 3414906 SGTC_1770 st043884 66.3 µM -0.870232638652866 0.193499333874285 no 2705 0.192086641320398 922 670149 SGTC_1048 3161-0300 24.5 µM -0.87105462462089 0.193266711536463 no 2706 0.191862164013838 871 2165101 SGTC_2518 prenyletin 46.28 µM -0.87111809129923 0.193248757543211 no 2707 0.191844838490306 871 3873459 A coumarin with calcium channel inhibitory activity. SGTC_710 3448-4187 58 µM -0.871164159270667 0.193235726081642 no 2708 0.191832263172576 885 3946412 SGTC_1030 k029-0042 36.7 µM -0.871946999860404 0.193014362324222 no 2709 0.191618645896849 902 6080581 SGTC_2886 9058944 51.95 µM -0.872372168188141 0.192894202432599 no 2710 0.191502689358585 847 4949929 SGTC_2429 5902844 64.44 µM -0.873708080282033 0.192516948094735 no 2711 0.191138624704201 891 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_161 4065-0411 162.148 µM -0.873708864896815 0.192516726656385 no 2712 0.191138411004643 905 1906281 YLR208W SEC13 SGTC_171 k064-0041 9.68 µM -0.874555988565291 0.192277737542032 no 2713 0.190907771846865 881 53325 SGTC_321 4534-3890 65.3 µM -0.874617303602418 0.192260446491338 no 2714 0.190891084751589 888 699746 SGTC_782 0083-0095 30.5 µM -0.87486096773103 0.192191741771871 no 2715 0.190824779576923 902 3591729 An indicator and reagent. SGTC_1352 1496-0991 99 µM -0.875573189083934 0.191991006512091 no 2716 0.190631053004056 914 3000039 SGTC_1472 k841-0093 193 µM -0.876128233438666 0.191834659631421 no 2717 0.190480162828411 905 X1472 SGTC_2019 4016004 108 µM -0.876212340321982 0.191810974906035 no 2718 0.190457304564951 910 45595336 SGTC_2080 5212524 12.4 µM -0.876682961897046 0.191678479639778 no 2719 0.190329431825899 886 260183 SGTC_344 k064-0035 6.43 µM -0.876699200289472 0.191673909005229 no 2720 0.190325020628453 868 5088750 SGTC_3040 9091894 49.47 µM -0.876962802945298 0.19159972187148 no 2721 0.190253421131996 845 25236966 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.878358454465068 0.191207229203792 no 2722 0.189874611426357 905 16623 A steroid. SGTC_1087 pterostilbene 9.05 µM -0.878444629165105 0.1911830108566 no 2723 0.189851236978263 906 5281727 Similar to reservatol, lowers cholesterol. SGTC_3177 9107506 49.47 µM -0.879077099123795 0.191005320457268 no 2724 0.189679736876813 879 8897194 SGTC_2380 9035439 200 µM -0.88237985856474 0.190079067362258 no 2725 0.18878571197391 902 6462575 SGTC_3095 9117207 49.47 µM -0.882855701022472 0.189945846053233 no 2726 0.188657120408687 895 17015229 SGTC_1891 st059073 26.2 µM -0.88320507355673 0.189848069000543 no 2727 0.188562740433863 883 688754 SGTC_1073 triclabendazole 3.09 µM -0.885679876859656 0.189156345208917 no 2728 0.187895027485256 887 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2866 9034245 58.44 µM -0.886320773347237 0.18897746374604 no 2729 0.187722349045856 881 6462273 SGTC_3139 9095020 49.47 µM -0.887545051719075 0.18863604358983 no 2730 0.187392761067812 836 25236292 SGTC_259 usnic acid 108.925 µM -0.889090450153386 0.18820561455754 no 2731 0.186977235447055 917 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2988 9073640 71.4286 µM -0.892999835269437 0.187119469440222 no 2732 0.185928630441481 900 9102229 SGTC_2152 5568786 200 µM -0.893363018132142 0.187018763475516 no 2733 0.185831400238193 903 5399883 SGTC_140 0062-0056 502.533 µM -0.893544548578282 0.186968439973944 no 2734 0.185782813285975 914 3758964 SGTC_3207 9114163 49.47 µM -0.893770268735144 0.186905877977157 no 2735 0.185722409869205 923 849233 SGTC_1579 chlormadinone acetate 49.4 µM -0.895265148783036 0.186491874810966 no 2736 0.18532268290297 918 45114258 A steroidal progestin. SGTC_2580 diallyl disulphide 81.36 µM -0.896280677682998 0.186210950938548 no 2737 0.185051438100918 894 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1800 st050079 29.0735 µM -0.897900989580688 0.185763270418657 no 2738 0.184619168529009 893 3645560 SGTC_1020 4335-0961 93.3 µM -0.898758551332018 0.185526602687656 no 2739 0.184390641049783 918 669075 SGTC_795 0685-0265 78 µM -0.899897111975497 0.185212674888035 no 2740 0.184087503600006 886 302754 SGTC_2099 5377090 177.372 µM -0.900353333983861 0.18508697644147 no 2741 0.183966123334462 904 2243829 SGTC_1106 tegaserod maleate 11.7 µM -0.901209788533573 0.184851148947047 no 2742 0.183738393725018 905 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_6 0844-0013 19.835 µM -0.903572222470386 0.184201613829755 no 2743 0.183111137972679 920 1584900 SGTC_2879 9041815 71.43 µM -0.903647486791717 0.184180943792674 no 2744 0.183091176335625 880 4942971 SGTC_631 k072-0230 41.5 µM -0.904162716303741 0.184039483736829 no 2745 0.182954563391186 926 5773147 SGTC_1326 1431-2094 10.8 µM -0.90565043084667 0.183631400540084 no 2746 0.182560453471565 915 616278 SGTC_176 1486-1328 72.834 µM -0.905909408511924 0.183560420090357 no 2747 0.182491902014705 897 22310231 SGTC_3332 9141069 11.198 µM -0.906174273072578 0.183487843852829 no 2748 0.182421808928534 910 17332883 SGTC_1867 st057372 64 µM -0.906438766560396 0.183415387145272 no 2749 0.182351830828068 880 688837 SGTC_1434 4073-0095 163 µM -0.908063024978121 0.182970820636119 no 2750 0.181922462130081 894 24133745 SGTC_3262 9137218 49.47 µM -0.909563339805597 0.182560775946831 no 2751 0.18152641983937 863 17650664 SGTC_2067 5224629 34.075 µM -0.911795338021588 0.181951820905131 no 2752 0.180938232485357 906 2835000 SGTC_1395 3486-0190 4.35 µM -0.912211649716423 0.181838379493969 no 2753 0.180828656249454 910 6748079 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.913186233838091 0.181572986625851 no 2754 0.180572301399031 891 165521 SGTC_1527 coumarin 137 µM -0.914370464564241 0.181250830486501 no 2755 0.18026110796664 934 323 A hepatotoxic, DNA x-linker. SGTC_1019 4262-0212 3.4 µM -0.914494763565661 0.181217037165425 no 2756 0.180228464069237 905 4677213 SGTC_2249 haloperidol 116.36 µM -0.914663612216484 0.181171138398413 no 2757 0.180184126309531 895 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1388 3346-4487 254 µM -0.915025917341042 0.181072676205278 no 2758 0.180089012160752 931 3345614 SGTC_2743 auranofin 4.32 µM -0.915192054877927 0.181027536894793 no 2759 0.180045407448698 875 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1931 st074438 57.1 µM -0.9158102583161 0.180859633918223 no 2760 0.179883211060861 921 2787313 SGTC_2664 lyso-paf C-16 73.48 µM -0.916549667879849 0.180658939806154 no 2761 0.179689334711459 905 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1857 st056007 79.3 µM -0.917943423519431 0.180281019797584 no 2762 0.179324243169257 897 619834 SGTC_2909 7941780 10.49 µM -0.918071412896897 0.180246340075901 no 2763 0.179290740003698 882 1243215 SGTC_261 5-fluorouridine 15.376 µM -0.918986280122328 0.179998571591539 no 2764 0.179051374237075 904 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2084 5306078 60.6385 µM -0.919894303169285 0.179752868253051 no 2765 0.178813998091075 929 679340 SGTC_422 cantharidin 155 µM -0.9211254263799 0.179420073437794 no 2766 0.178492473360686 918 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_954 1189-0853 2.85 µM -0.922731110485093 0.178986610524202 no 2767 0.178073674498091 898 2828194 SGTC_2157 5649910 96.377 µM -0.923685719206241 0.178729221456887 no 2768 0.177824984753719 921 2858091 SGTC_2395 5646831 180.19 µM -0.924255998383847 0.178575569571906 no 2769 0.177676523142122 928 6808628 SGTC_1418 3966-3099 2.4 µM -0.924593594983615 0.178484649205783 no 2770 0.177588672989262 888 740335 SGTC_1411 3909-8223 150 µM -0.924800392422439 0.17842896962832 no 2771 0.17753487323179 909 X1411 SGTC_496 calpeptin 138 µM -0.924904792366004 0.178400864420088 no 2772 0.177507716785712 903 73364 A calpain inhibitor. SGTC_2113 5491891 107.031 µM -0.930909280220694 0.176789108551867 no 2773 0.175950246817552 905 789979 SGTC_1673 st016611 27.3 µM -0.932219091129381 0.176438749037147 no 2774 0.175611655576041 932 5226799 SGTC_21 0849-0113 22.993 µM -0.933784423940342 0.176020616874215 no 2775 0.175207552876307 895 1560156 SGTC_2402 5553605 200 µM -0.93408799698942 0.175939599044762 no 2776 0.175129251489513 929 6758546 SGTC_2452 5863136 48.41 µM -0.934415909896684 0.175852111908156 no 2777 0.175044697001386 914 2184096 SGTC_151 3013-0144 2.285 µM -0.935256332650295 0.175628013017546 no 2778 0.174828106773065 910 906558 YHR107C CDC12 SGTC_1671 st016596 74.5 µM -0.935626429477041 0.175529384043814 no 2779 0.174732780940212 911 2829167 SGTC_1132 3456-3614 2.5 µM -0.935661351249243 0.17552007937706 no 2780 0.174723787843941 927 3125502 SGTC_2552 juarezic acid 87.02 µM -0.935930460306964 0.175448387600565 no 2781 0.174654496416647 915 1549512 SGTC_2971 9092186 9.93 µM -0.935975055234307 0.175436509118848 no 2782 0.174643015596839 901 25236400 SGTC_2214 7179297 48.276 µM -0.940315515009866 0.174282807135388 no 2783 0.173527871795663 916 769744 SGTC_613 3914-0030 117 µM -0.940752808359619 0.174166841690035 no 2784 0.173415774919629 880 1145395 SGTC_3082 9117008 49.47 µM -0.94235429903911 0.173742562567266 no 2785 0.17300563840918 913 41448529 SGTC_55 0767-0285 6.563 µM -0.943366278670211 0.173474800491253 no 2786 0.17274679263388 913 3116166 SGTC_2163 5671233 125 µM -0.944142418133529 0.173269617984239 no 2787 0.172548437792725 891 701023 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.944580173405934 0.173153959900615 no 2788 0.172436626523594 911 5355888 SGTC_484 loperamide 105 µM -0.945682713968149 0.172862878704776 no 2789 0.172155220897914 886 3955 An opioid-receptor agonist. SGTC_1820 st053765 18.6 µM -0.948017928886271 0.172247390116046 no 2790 0.171560163489524 912 3690829 SGTC_975 1335-0046 28.5 µM -0.948323544068393 0.17216694324892 no 2791 0.171482384267266 928 16486740 SGTC_342 k048-0088 23.3 µM -0.952087888714963 0.171178024639612 no 2792 0.170526205378052 920 6820570 SGTC_3219 9131112 49.47 µM -0.953471994667533 0.1708153258645 no 2793 0.170175489532291 894 17612988 YMR079W SEC14 SGTC_2207 7258803 200 µM -0.95383989129861 0.170719002990411 no 2794 0.170082346746913 913 3666799 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.954419364931801 0.170567355444547 no 2795 0.169935703909271 909 2333 A French combination drug. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.956095545040604 0.170129186880838 no 2796 0.169511982666529 905 5711223 A potent inhibitor of glutathione S-transferases. SGTC_978 1416-0512 87.4 µM -0.956280819949664 0.170080798663277 no 2797 0.169465188700505 934 6814003 SGTC_2946 9065502 71.43 µM -0.956617926633256 0.169992779193148 no 2798 0.169380068599405 857 16489101 SGTC_2 0422-0095 29 µM -0.956860543615538 0.16992944931332 no 2799 0.169318824318028 894 6790840 SGTC_125 0133-0007 11.75 µM -0.956875961660283 0.169925425279703 no 2800 0.169314932791125 902 26541 SGTC_1185 1319-0113 81.3 µM -0.956946695383218 0.169906964910015 no 2801 0.169297080278404 926 4672763 SGTC_3029 9088683 49.47 µM -0.95706929457347 0.169874971529131 no 2802 0.169266140281837 912 25236615 SGTC_203 k066-0004 30.888 µM -0.957188397076891 0.169843894339851 no 2803 0.169236086210158 946 6795412 SGTC_3069 9117009 49.47 µM -0.958705249270146 0.169448423878201 no 2804 0.168853626642616 902 41904981 SGTC_2394 5221648 200 µM -0.960756020183914 0.168914691583718 no 2805 0.168337428306324 933 788586 SGTC_3331 9141060 1.957 µM -0.961949311478342 0.168604623966846 no 2806 0.16803753326529 909 4906567 YPR165W RHO1 SGTC_823 0417-1665 178 µM -0.962078203580833 0.1685711542476 no 2807 0.16800516100567 941 3429856 SGTC_1925 st057770 10.1 µM -0.962252427274743 0.168525919955202 no 2808 0.167961409742261 920 5989122 SGTC_340 k038-0059 454 µM -0.962537802533053 0.168451843864456 no 2809 0.167889761809786 914 23733424 SGTC_2115 tiliquinol 12.7705 µM -0.96281951650074 0.168378738689618 no 2810 0.167819052402517 919 71208 A bioactive hydroxyquinoline. SGTC_2531 methyl deoxycholate 70.07 µM -0.963211876594888 0.168276954691027 no 2811 0.167720603084675 946 16667744 Haematoxylin. SGTC_1303 1160-0052 261 µM -0.963663903074657 0.168159741424951 no 2812 0.167607228647508 897 3562476 SGTC_1634 st006576 41 µM -0.966123678352026 0.167522827412024 no 2813 0.166991148718612 909 3915356 SGTC_1054 3429-0080 167 µM -0.966761273839957 0.167357987627808 no 2814 0.166831693999903 929 1162877 SGTC_2671 danthron 100 µM -0.968244816708243 0.166974846824032 no 2815 0.1664610586386 913 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_363 0455-0021 3.06 µM -0.969117523408144 0.166749725469207 no 2816 0.166243277764721 907 4597466 SGTC_1171 0368-0077 21.4 µM -0.969195126922535 0.166729716536091 no 2817 0.166223920995474 910 3239779 SGTC_3021 9087658 49.47 µM -0.971892299036181 0.166035252805238 no 2818 0.165552065663461 913 25237042 SGTC_1888 azatryptophan 97.5 µM -0.971948307132789 0.16602085176355 no 2819 0.165538132899422 923 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1805 st050013 60.3 µM -0.972151536015949 0.165968603460629 no 2820 0.165487583362288 904 4037144 SGTC_540 1187-0821 17.3 µM -0.973489186133981 0.165624970926501 no 2821 0.165155116083501 921 847520 SGTC_1428 4049-0204 61.7 µM -0.97441245151683 0.165388059374684 no 2822 0.164925894744766 929 X1428 SGTC_2010 4012422 159 µM -0.975630709755216 0.165075787822303 no 2823 0.164623750248753 923 952393 SGTC_2791 5663188 71.43 µM -0.980258661416853 0.163893004136967 no 2824 0.163479227326552 930 54690634 SGTC_400 oxethazaine 37.5 µM -0.981244924489397 0.163641653664606 no 2825 0.163235987583857 921 4621 A local anesthetic. SGTC_1389 3405-0187 19 µM -0.981899331485472 0.163475015356271 no 2826 0.163074722576379 906 799890 SGTC_3033 9090887 49.47 µM -0.981921010022141 0.16346949701657 no 2827 0.163069382124064 932 19325384 SGTC_1444 4112-3581 28 µM -0.984441109069319 0.162828822413867 no 2828 0.162449336883385 922 2877249 SGTC_3086 9117350 49.47 µM -0.988897742066476 0.161699833280808 no 2829 0.161356587692026 895 2679265 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.990434186540988 0.161311794634385 no 2830 0.16098097131541 935 390807 SGTC_269 exalamide 29 µM -0.991316981775563 0.161089114161343 no 2831 0.160765411695272 925 3316 A derivative of salicylamide. SGTC_1935 st074532 41.6 µM -0.992916843073997 0.160686068938485 no 2832 0.160375240464062 905 2829742 SGTC_2847 9005661 71.43 µM -0.993163230789814 0.160624056259135 no 2833 0.160315206913315 905 2991449 SGTC_1117 retinoic acid 1.10837 µM -0.99336289105701 0.160573815756167 no 2834 0.160266569504144 951 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_918 glabranin 770.725 nM -0.994436915934243 0.160303735071908 no 2835 0.160005101637491 934 124049 Also referred to as licorice root. SGTC_2105 5350118 200 µM -0.996490184566637 0.159788234739453 no 2836 0.159506016906744 924 2133313 SGTC_234 nsc-17383 10.7 µM -0.996513039710486 0.159782502762264 no 2837 0.159500467284058 895 408974 SGTC_1559 coumarin 343 70.1 µM -0.997515390979418 0.159531249460206 no 2838 0.159257203452303 926 108770 A hepatotoxic, DNA x-linker. SGTC_2003 4023581 200 µM -1.0000590751612 0.158894801083596 no 2839 0.158640959894125 923 16641307 SGTC_282 k297-0036 65.7 µM -1.00081576604984 0.158705793073135 no 2840 0.158457942941973 947 5061378 SGTC_653 0203-0016 55.2 µM -1.00089250090729 0.15868663429705 no 2841 0.158439391212115 942 295302 SGTC_2843 9000894 45.46 µM -1.00367780861203 0.157992239076215 no 2842 0.157766968394699 886 2242070 SGTC_1484 3473-2379 286 µM -1.00515470263086 0.15762485041849 no 2843 0.157411181484092 975 671917 SGTC_2765 myclobutanil 7.74 µM -1.00534298031401 0.157578055278294 no 2844 0.157365862919575 937 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2071 5230951 39.92 µM -1.00541089931784 0.157561176711509 no 2845 0.157349516874994 936 1799272 SGTC_2382 9035899 200 µM -1.00543360710629 0.157555533858931 no 2846 0.157344052047901 931 6462679 SGTC_2861 9024595 19.48 µM -1.00549822347083 0.157539477512395 no 2847 0.15732850223956 906 16482810 SGTC_2056 5235370 200 µM -1.00852214987585 0.156789272777499 no 2848 0.156601929853924 945 5511916 SGTC_3114 9122766 49.47 µM -1.00853491021597 0.156786112059093 no 2849 0.156598868557476 895 17176985 SGTC_189 3970-0742 2.116 µM -1.00911539010917 0.156642372341774 no 2850 0.15645964895801 926 2891807 SGTC_2141 5621638 7.665 µM -1.01050567592954 0.156298459477134 no 2851 0.156126540730994 938 2856238 SGTC_2407 paclitaxel 400 µM -1.01113721208823 0.156142401752965 no 2852 0.155975381064843 969 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_361 000s-0510 1.45 µM -1.0125368135545 0.155796914860528 no 2853 0.155640727050003 927 660 SGTC_650 1328-0195 38 µM -1.01603245448321 0.154936230849929 no 2854 0.154806966005131 943 2780821 SGTC_1302 1159-0335 255 µM -1.01641217253562 0.154842927499923 no 2855 0.154716575739391 925 649284 SGTC_2805 7950783 58.44 µM -1.01778275293437 0.15450646081045 no 2856 0.154390605064507 926 1178958 YDL195W SEC31 SGTC_2289 7946404 165.07 µM -1.01931042295664 0.154131999817731 no 2857 0.154027808631293 917 1246120 YPR165W RHO1 SGTC_3149 9097855 49.47 µM -1.02331637388692 0.153152918376896 no 2858 0.15307914220766 899 25236625 YMR079W SEC14 SGTC_1776 st049249 45.9 µM -1.02337333918865 0.153139025461747 no 2859 0.153065679998212 946 1822314 SGTC_622 1348-1566 26.3 µM -1.03238330514525 0.150952152878551 no 2860 0.150946294836344 926 7340407 SGTC_2192 5915882 198.485 µM -1.03426194726517 0.150498806077519 no 2861 0.150506860557363 926 2876149 SGTC_2415 st077333 57.7 µM -1.03951025377078 0.149237115154429 no 2862 0.149283745886197 911 2766255 SGTC_1230 0170-0365 3.77 µM -1.04204254191552 0.148630887351633 no 2863 0.14869597788638 904 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2385 9074692 200 µM -1.04447272821316 0.148050652829622 no 2864 0.148133365202409 936 17046906 SGTC_1199 1638-0010 4.46 µM -1.04617695236762 0.147644655520457 no 2865 0.147739670905512 926 3111136 SGTC_198 3454-2873 16.191 µM -1.04873642948423 0.147036313496833 no 2866 0.14714972137076 930 710957 SGTC_870 0573-2213 57.6 µM -1.049855031384 0.146770970348911 no 2867 0.146892384608055 929 3916321 SGTC_2252 omeprazole 400 µM -1.05084433615458 0.146536565586469 no 2868 0.146665044609841 927 4594 A proton pump inhibitor. SGTC_1693 xanthone 101.9 µM -1.05293319669613 0.146042459097056 no 2869 0.146185805097338 953 7020 An insecticide. SGTC_679 0422-0091 41.4 µM -1.05390399322434 0.145813204859796 no 2870 0.145963437245548 962 627384 YHR062C RPP1 SGTC_2241 6772625 37.8075 µM -1.05414557210629 0.145756193453458 no 2871 0.145908137218428 934 2285411 SGTC_74 000s-0487 160.283 µM -1.05797797785526 0.144853769181747 no 2872 0.14503274125037 943 677548 SGTC_957 1187-1561 14.1 µM -1.05824387784831 0.144791297045787 no 2873 0.144972135948949 935 1538454 SGTC_767 0929-0023 86 µM -1.05939532283112 0.144520979094396 no 2874 0.144709889438795 947 1204563 SGTC_2933 9026794 32.47 µM -1.06377334807504 0.143496281686527 no 2875 0.143715693845041 930 17586027 SGTC_2801 7907800 81.82 µM -1.0643083027078 0.143371410138758 no 2876 0.143594529000011 925 6620925 SGTC_1047 2043-3044 82 µM -1.06475059576173 0.14326822350493 no 2877 0.143494403672734 988 669592 SGTC_2543 pimpinellin 60.67 µM -1.06757137432136 0.142611318115927 no 2878 0.1428569509589 934 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2912 7964298 10.93 µM -1.06779402639816 0.14255955357046 no 2879 0.142806716629171 935 2975850 SGTC_488 nitrendipine 139 µM -1.06801828789267 0.142507427696415 no 2880 0.142756131257146 973 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1285 0929-0069 65.5 µM -1.06809455617324 0.14248970333419 no 2881 0.142738930621515 948 1206237 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.06809678648687 0.142489185043035 no 2882 0.142738427644346 955 23847180 SGTC_1712 st032288 53.4 µM -1.06928156170614 0.142214041436887 no 2883 0.14247140818241 942 2883011 SGTC_2493 resveratrol 26.09 µM -1.07270289941027 0.14142151402037 no 2884 0.141702219534972 912 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1864 st057645 30.4 µM -1.07363523216252 0.141206066036421 no 2885 0.141493100145224 946 688666 SGTC_859 0439-0102 54.6 µM -1.07942419831332 0.139873305303338 no 2886 0.140199334212995 943 610143 SGTC_551 k048-0028 34.9 µM -1.08267405614494 0.139128868048206 no 2887 0.139476561747674 953 6836383 SGTC_605 1315-0399 119 µM -1.08325206466151 0.138996747988796 no 2888 0.139348277873254 949 24020461 SGTC_2087 5276107 200 µM -1.08453881593963 0.138702931700012 no 2889 0.13906298315419 932 144405 SGTC_2820 7989630 71.43 µM -1.0856412346967 0.13845154254938 no 2890 0.138818874553974 910 2984098 SGTC_397 arbidol 50 µM -1.08767461956443 0.137988676269385 no 2891 0.138369388027669 947 131410 A RNA synthesis inhibitor. SGTC_1478 0453-0656 35.7 µM -1.08788536798779 0.137940763328426 no 2892 0.138322858183099 981 5258496 SGTC_2043 5101342 149 µM -1.08905042637801 0.137676096031656 no 2893 0.138065824592069 967 678451 SGTC_2384 9036245 200 µM -1.09026301511734 0.137400999514882 no 2894 0.137798651054437 917 6462766 SGTC_1534 6-azauridine 81.6 µM -1.09046181662338 0.137355933826162 no 2895 0.13775488216676 953 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1583 clindamycin 39.6 µM -1.09144041033199 0.137134246630656 no 2896 0.137539569581272 966 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2445 5742597 35.57 µM -1.09145321986496 0.137131346425489 no 2897 0.13753675272054 953 1774255 SGTC_2420 aureobasidin a 50 nM -1.09208905881682 0.136987438847543 no 2898 0.137396979022723 956 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2636 apigenin dimethyl ether 100 µM -1.09244541865848 0.136906830104864 no 2899 0.137318684423988 964 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3356 9151811 4.48 µM -1.09355832553179 0.136655298849418 no 2900 0.137074367657502 958 1859254 YPR165W RHO1 SGTC_1503 4585-0012 61.3 µM -1.09648678876238 0.135994938911182 no 2901 0.136432900871406 960 2922052 SGTC_1739 st037196 92.5 µM -1.09682745871043 0.135918260919505 no 2902 0.136358412192077 944 612214 SGTC_2368 9071271 200 µM -1.09704141856634 0.135870117972165 no 2903 0.136311643346236 962 27209959 SGTC_794 k038-0031 316 µM -1.09737201992453 0.135795752570472 no 2904 0.136239399765944 941 6624242 SGTC_2195 6536160 144.242 µM -1.09939797815055 0.135340642794905 no 2905 0.135797256144496 949 3834386 SGTC_739 1486-1183 203 µM -1.10340546562279 0.13444348590804 no 2906 0.134925562104044 947 4346692 SGTC_2628 lathosterol 100 µM -1.10637107944809 0.133782207920954 no 2907 0.134282968936555 962 6710616 SGTC_2126 5251174 33.877 µM -1.1065624909628 0.133739603577276 no 2908 0.134241565961833 958 790722 SGTC_1830 st055982 50.3 µM -1.11207279986362 0.132517117983065 no 2909 0.133053425292151 972 455313 An antimicrobial agent. SGTC_483 fpl-64176 144 µM -1.11336995275041 0.132230462175977 no 2910 0.132774787108486 967 3423 SGTC_716 1683-5115 658 µM -1.11371001166989 0.132155383856081 no 2911 0.132701806430781 952 723597 SGTC_2910 7948405 25.97 µM -1.11406274825895 0.132077537616365 no 2912 0.132626134173864 904 2971328 SGTC_1848 st056003 16.4 µM -1.1145249594957 0.131975579039751 no 2913 0.132527021424797 926 146492 SGTC_2360 9040895 200 µM -1.11470879010514 0.131935043176625 no 2914 0.132487616499697 960 4914414 SGTC_2541 muurolladie-3-one 83.07 µM -1.11539171702696 0.131784528496545 no 2915 0.132341298724997 934 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_937 3122-0005 46.7 µM -1.11655092313905 0.131529314864979 no 2916 0.132093192706048 947 759535 SGTC_1417 3966-0327 90.4 µM -1.11873598428554 0.131049174600099 no 2917 0.131626394450507 978 651118 SGTC_3062 9077494 49.47 µM -1.12239941908298 0.130246899658794 no 2918 0.130846325683762 853 16459633 SGTC_1678 st019265 80.2 µM -1.12383087223247 0.129934343401336 no 2919 0.130542390924816 948 5367020 SGTC_1190 1486-1332 13 µM -1.12450860558627 0.129786542314167 no 2920 0.130398660916416 954 4150046 SGTC_166 k072-0058 166.424 µM -1.12586581862774 0.129490909412153 no 2921 0.130111159726797 956 5846229 SGTC_502 l-744,832 89.3 µM -1.12587302561457 0.129489340807366 no 2922 0.130109634227999 963 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2561 acetosyringone 100 µM -1.12659266154586 0.129332777921963 no 2923 0.129957371622675 961 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1496 4469-0713 57.4 µM -1.12800837207231 0.129025161142953 no 2924 0.129658191716693 988 746691 SGTC_93 0109-0045 59.227 µM -1.12822507325021 0.128978119408605 no 2925 0.129612438726842 969 88733 SGTC_2701 st077767 14.721 µM -1.13046034687942 0.128493577771875 no 2926 0.129141149029092 952 5721188 SGTC_394 menadione 8.33 µM -1.13213064469521 0.128132332095812 no 2927 0.128789756479923 967 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2304 7443016 91.4 µM -1.13441888996261 0.127638585139838 no 2928 0.128309439517798 959 939854 SGTC_1076 itraconazole 331 nM -1.13572821339661 0.127356661089064 no 2929 0.12803516449832 960 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1038 k292-0204 154 µM -1.13663280840362 0.12716213649298 no 2930 0.127845909417798 947 4454212 SGTC_3282 9108498 15.4605 µM -1.13733413979621 0.127011464153085 no 2931 0.127699314036927 967 16459645 SGTC_3192 9110362 49.47 µM -1.13848258655138 0.126765003040028 no 2932 0.127459513034645 993 16649480 SGTC_836 0330-0104 1.35 µM -1.13883041150618 0.126690424203582 no 2933 0.127386947396452 925 46494820 SGTC_747 3448-8087 38.7 µM -1.13924382186133 0.126601822630269 no 2934 0.127300736257803 985 5168703 SGTC_1275 0867-0008 21.1 µM -1.14224158167019 0.125960637704801 no 2935 0.12667680812988 961 3422836 SGTC_851 0394-0702 453 µM -1.14318023660024 0.125760336977205 no 2936 0.126481883047439 972 762646 SGTC_2890 9046729 58.44 µM -1.14467308955766 0.125442233130733 no 2937 0.126172301451629 953 903329 SGTC_1742 st038235 28.8875 µM -1.14468724926703 0.125439218607037 no 2938 0.126169367601244 959 564103 YBR002C RER2 SGTC_4 0960-0234 25.671 µM -1.14599947148489 0.125160073205179 no 2939 0.125897685371288 940 6821112 SGTC_3090 9117696 49.47 µM -1.147789211014 0.124780046606314 no 2940 0.125527796146747 931 7923821 SGTC_1049 3226-0134 66 µM -1.14895908139342 0.124532076921993 no 2941 0.125286426845731 954 5702385 SGTC_406 estrone 100 µM -1.14976731611064 0.124360962109304 no 2942 0.125119860100367 956 5870 A steroid. SGTC_857 0438-0306 1.35 µM -1.14976933534122 0.124360534815414 no 2943 0.125119444156763 938 4686136 SGTC_1803 st050068 52.4 µM -1.15009924640425 0.124290735386467 no 2944 0.125051498369318 964 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1934 st074720 32.6 µM -1.1503427006919 0.124239245229235 no 2945 0.125001375041838 950 17250992 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.15081462025921 0.124139477561921 no 2946 0.124904254354386 971 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3214 9129694 49.47 µM -1.15601999370152 0.12304273688397 no 2947 0.123836489498295 985 17158655 SGTC_1597 7-benzyloxygramine 47.5 µM -1.15908577777838 0.122399982127687 no 2948 0.123210611231502 957 260807 SGTC_1616 st002734 56.1 µM -1.1598939787185 0.122230932528563 no 2949 0.123045987278003 957 4026101 SGTC_2354 9060492 162 µM -1.16189504174337 0.121813080132139 no 2950 0.122639050708817 984 6471895 SGTC_2310 7668677 200 µM -1.16230202885703 0.121728217990037 no 2951 0.12255640139768 971 2197143 SGTC_1998 st075797 76.8 µM -1.16773489506015 0.120599371447715 no 2952 0.12145685828833 938 24208315 SGTC_2128 5255449 168.493 µM -1.17160728323007 0.11979927491701 no 2953 0.120677381303676 948 736008 SGTC_2390 9097792 176.6 µM -1.17355887486554 0.11939746681197 no 2954 0.120285880906624 957 4497149 SGTC_473 2-arachidonoylglycerol 10 µM -1.17523380127705 0.119053379635736 no 2955 0.119950595328211 940 5282280 An endocannabinoid. SGTC_3050 9093513 49.47 µM -1.18124773295756 0.117823684352114 no 2956 0.118752162024362 946 25236664 SGTC_3240 9133527 49.47 µM -1.18166640012793 0.117738413474719 no 2957 0.118669047677631 965 17617455 SGTC_1879 gemcitabine 100 µM -1.18218827928053 0.11763218234615 no 2958 0.118565501113578 987 60750 A nucleoside analog which inhibits DNA replication. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.1823012828924 0.11760918883083 no 2959 0.11854308836595 988 803109 SGTC_520 3584-0023 682 µM -1.18253051984087 0.117562554402691 no 2960 0.118497631495972 961 1340790 SGTC_2112 5488546 200 µM -1.18288056985217 0.117491367834896 no 2961 0.118428241597648 1005 600757 SGTC_3306 9127676 59.7925 µM -1.18364296229261 0.117336432474671 no 2962 0.118277213075137 955 41905287 SGTC_253 dyclonine 31.25 µM -1.18527061133787 0.117006141788867 no 2963 0.117955234656473 980 3180 An oral anasthetic. SGTC_2873 9040596 71.43 µM -1.18535519907843 0.116988994849165 no 2964 0.117938518637649 982 6463863 SGTC_535 2293-4129 48.2 µM -1.18837129490629 0.116378759789383 no 2965 0.117343580196499 994 396118 YIL048W NEO1 SGTC_2322 7413319 38.22 µM -1.19017670855044 0.116014559634222 no 2966 0.116988472821783 937 1840400 SGTC_1240 0356-0016 42.1 µM -1.19069145601534 0.115910869707176 no 2967 0.116887366642948 921 4305613 SGTC_2948 9070189 9.45 µM -1.20043189549666 0.113961162983128 no 2968 0.114985823871248 922 6473636 YDL196W YDL196W SGTC_1916 st067606 49.2 µM -1.20308354077012 0.113434463062284 no 2969 0.114471997003967 936 19590279 SGTC_762 1165-0429 115 µM -1.20314748711543 0.113421782785756 no 2970 0.114459625913037 963 5967793 SGTC_2880 9042983 58.44 µM -1.20419576265167 0.113214058501242 no 2971 0.114256961688417 978 6464714 SGTC_3093 9117344 49.47 µM -1.20552570594861 0.112950910266411 no 2972 0.114000210265202 958 24824913 SGTC_192 3455-0609 60.9 µM -1.20935828071233 0.112195023378896 no 2973 0.113262614609982 980 3769639 SGTC_2447 5741742 33.78 µM -1.21053772583778 0.111963134232777 no 2974 0.113036311842332 975 1776504 SGTC_2032 5185112 25.99 µM -1.21064319793579 0.1119424142084 no 2975 0.11301609040536 950 5718189 SGTC_561 1550-0330 72.9 µM -1.21166016195647 0.111742771991294 no 2976 0.112821247365913 979 6812934 SGTC_2398 5228213 48.84 µM -1.21201800280215 0.111672584158348 no 2977 0.112752744689864 985 80771 YMR134W ERG29 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.2121190032288 0.111652779380761 no 2978 0.112733415213953 996 5393153 SGTC_997 3996-0078 137 µM -1.2149097696162 0.111106542576107 no 2979 0.112200253615366 969 735687 SGTC_3054 9094397 49.47 µM -1.21909010590806 0.110291909702417 no 2980 0.111404997382899 985 2598354 SGTC_2161 5662504 8.5105 µM -1.22164909276947 0.109795351834321 no 2981 0.110920177560024 930 2859334 SGTC_614 0462-0418 107 µM -1.22330176002101 0.109475514505425 no 2982 0.110607871328787 957 5188303 SGTC_1088 bifonazole 369 nM -1.22464889820468 0.10921530103074 no 2983 0.110353767881036 978 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1284 0929-0043 16 µM -1.22496571666087 0.109154168915222 no 2984 0.110294068961911 981 1239883 SGTC_844 0330-0132 15.3 µM -1.22589245585517 0.108975489922143 no 2985 0.110119574074238 970 2828079 SGTC_681 1642-0006 26.6 µM -1.22727826390929 0.108708693044115 no 2986 0.109859011154717 1012 4446530 SGTC_2693 st077581 40.7 µM -1.22749611311778 0.108666795301714 no 2987 0.109818090909576 940 25238761 SGTC_1457 k015-0032 57.3 µM -1.22840933743518 0.108491286267905 no 2988 0.109646672213341 977 4302660 SGTC_803 4488-1585 147 µM -1.23092330247093 0.108009190745713 no 2989 0.109175775652585 961 747204 SGTC_232 clozapine 119 µM -1.23113398388955 0.107968859165409 no 2990 0.109136378527917 978 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1473 k844-0725 134 µM -1.23390733732881 0.107438955812866 no 2991 0.108618717553419 977 54682906 SGTC_1367 1812-0510 76.9 µM -1.23397199993749 0.107426623160301 no 2992 0.108606669043068 965 1142582 YDR527W RBA50 SGTC_1438 4092-1045 4 µM -1.23737173913659 0.106779650836339 no 2993 0.107974552843407 972 1351342 SGTC_2488 5268135 45.7 µM -1.23883010401419 0.106502986589163 no 2994 0.107704211415411 983 1270356 YLR208W SEC13 SGTC_2825 7998094 58.44 µM -1.24232057550546 0.10584291686809 no 2995 0.107059153401065 984 2987815 SGTC_2175 5807670 165.306 µM -1.24322370303302 0.10567261240247 no 2996 0.106892705232639 936 241186 SGTC_1036 k216-0215 33.5 µM -1.24452317807318 0.105427915694688 no 2997 0.106653537148929 904 622330 SGTC_2996 9066192 71.4286 µM -1.24554433561989 0.105235915137382 no 2998 0.106465864526393 975 6472854 SGTC_1571 st070080 73.4 µM -1.24847499435985 0.104686290739137 no 2999 0.10592858009816 963 4315245 SGTC_1167 k781-0610 148 µM -1.24927106887762 0.10453735228721 no 3000 0.105782972931842 970 4525169 SGTC_143 4032-1194 15.74 µM -1.25048178559824 0.104311132335088 no 3001 0.105561802463583 979 1806963 SGTC_3213 9129884 49.47 µM -1.25077731017532 0.104255968079899 no 3002 0.105507867640351 979 17190742 SGTC_2246 7293507 91.5585 µM -1.25371385019164 0.103708965900191 no 3003 0.10497301595947 985 887656 SGTC_1468 k284-1086 134 µM -1.25594878822776 0.103294051763074 no 3004 0.104567269066494 983 15996457 SGTC_2296 7971656 126.45 µM -1.25653107950799 0.103186148113025 no 3005 0.104461742483438 976 666570 SGTC_1602 st001878 87.6 µM -1.26119612192311 0.102324628716984 no 3006 0.103619097765206 987 595405 YLR310C CDC25 SGTC_858 0438-0351 2.77 µM -1.27006223626976 0.100701715674276 no 3007 0.102031230994302 991 2799119 SGTC_2011 4012611 177 µM -1.27053642045837 0.100615449735336 no 3008 0.101946809072024 996 2049887 SGTC_2790 5423970 71.43 µM -1.27429146418988 0.0999342165932835 no 3009 0.101280070235023 975 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2309 7664088 163.95 µM -1.27675136037238 0.0994897766330747 no 3010 0.100845021258667 964 704922 SGTC_1178 0988-0033 191 µM -1.27695973852902 0.0994521945377174 no 3011 0.100808230896595 979 5392207 SGTC_863 0466-0191 129 µM -1.27880287259028 0.0991202273566724 no 3012 0.100483241051283 989 765160 YPR165W RHO1 SGTC_3279 9140807 49.47 µM -1.27989407344919 0.0989240733069233 no 3013 0.100291196128998 1010 45595718 SGTC_1944 st076371 56.9 µM -1.28508414799487 0.0979949935031263 no 3014 0.0993814401848489 985 24208455 SGTC_2329 6138490 200 µM -1.28599542603652 0.0978325269038465 no 3015 0.0992223289937416 1003 720019 SGTC_308 4092-1169 104 µM -1.28721494896728 0.0976154141000431 no 3016 0.0990096891045092 994 2268590 YDL196W YDL196W SGTC_3081 9117243 49.47 µM -1.28746545523781 0.0975708600103787 no 3017 0.0989660513361226 993 45595589 SGTC_926 2268-1401 59.4 µM -1.28970045686 0.0971740110595533 no 3018 0.0985773404593871 989 2931578 SGTC_933 2914-0560 114 µM -1.29051476096043 0.0970297172678096 no 3019 0.0984359950583153 983 463887 SGTC_1283 0922-0125 16.4 µM -1.29522162823652 0.0961987465065875 no 3020 0.0976218929109956 968 3360884 SGTC_2553 4-methylesculetin 85.09 µM -1.30002283740273 0.0953565220517147 no 3021 0.0967965710301534 987 5319502 SGTC_1774 st048371 48.465 µM -1.30242550959546 0.094937090742221 no 3022 0.0963854834553134 998 4242727 SGTC_3119 9125183 49.47 µM -1.30250590170387 0.0949230803348986 no 3023 0.096371750903942 970 22695334 SGTC_3076 9116187 49.47 µM -1.30348332916075 0.094752860113196 no 3024 0.0962049020916342 982 27241210 SGTC_735 3076-0345 636 µM -1.30392408499696 0.0946761755623044 no 3025 0.0961297336970927 987 2888990 SGTC_1470 k295-0292 231 µM -1.3065548616885 0.094219413131889 no 3026 0.0956819675827581 1015 5045612 SGTC_712 r015-0009 80.6 µM -1.31158549794445 0.0933505103989081 no 3027 0.0948300143801354 1000 6813872 YLR060W FRS1 SGTC_3352 9151559 45.5865 µM -1.31821443954728 0.0922146035166636 no 3028 0.0937159365645765 984 17159339 SGTC_2953 9074162 66.49 µM -1.3193062301872 0.0920285044781521 no 3029 0.0935333779112761 977 16451992 SGTC_459 nigericin 15.3 µM -1.3198349745957 0.0919384783976021 no 3030 0.0934450608469032 1005 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2907 7721985 69.9 µM -1.32363713911492 0.0912930270549079 no 3031 0.0928117922799074 1001 3267881 SGTC_3244 9134489 49.47 µM -1.32515086752093 0.0910369952981082 no 3032 0.0925605587686697 1011 16584271 SGTC_1204 4049-0315 18.3 µM -1.32540168971546 0.0909946227631416 no 3033 0.0925189784410683 985 588402 SGTC_2331 7980721 200 µM -1.32825305057932 0.090513957441517 no 3034 0.0920472620471213 978 2981221 SGTC_2469 5655019 90.81 µM -1.33212825076026 0.0898637247148303 no 3035 0.0914090242320976 998 2788239 SGTC_887 0885-0007 9.62 µM -1.33249995395441 0.0898015383446801 no 3036 0.0913479782913201 1012 5719458 SGTC_1062 mesoridazine 14.2 µM -1.33554310712219 0.0892936178726222 no 3037 0.0908493282504806 981 4078 A neuroleptic. SGTC_1218 1348-1416 30.7 µM -1.33671848857808 0.089098012909275 no 3038 0.0906572722930111 985 6787668 SGTC_145 3737-0113 38.366 µM -1.33680879179131 0.0890829980054202 no 3039 0.0906425293283644 984 6849351 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.33759100856443 0.0889530159882971 no 3040 0.0905148985430556 985 23665772 A membrane-active detergent. SGTC_1041 0206-0046 107 µM -1.33831248133355 0.0888332530987293 no 3041 0.0903972974084434 1004 50494 SGTC_1949 st076024 69.1 µM -1.34124736994913 0.0883473054708335 no 3042 0.0899200755910923 1001 2921930 SGTC_298 1391-0729 10 µM -1.34645399326739 0.0874900916696374 no 3043 0.0890780740377791 1005 3237558 SGTC_1938 st074717 56.4 µM -1.34675225342121 0.0874411750259721 no 3044 0.0890300184899149 956 17250979 SGTC_2051 5263410 176 µM -1.35141493760369 0.0866791157652996 no 3045 0.0882812757134692 999 227584 SGTC_2274 7947094 46.08 µM -1.35220281059581 0.086550839182542 no 3046 0.0881552224212685 1004 2971028 SGTC_374 0880-0231 82.3 µM -1.35281621384953 0.0864510669704111 no 3047 0.0880571758046313 979 6833587 SGTC_2742 clothiapine 36.27 µM -1.3532932830514 0.0863735294409237 no 3048 0.0879809771005177 1006 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_247 mechlorethamine 29.705 µM -1.35858506099769 0.0855169473053052 no 3049 0.0871390558440756 990 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2986 9022445 71.43 µM -1.36171836526907 0.0850127656264608 no 3050 0.0866433915467882 983 6459286 SGTC_2797 7859098 81.82 µM -1.364232282623 0.0846098633271962 no 3051 0.0862472354410115 978 972681 SGTC_1764 st044502 93.5 µM -1.3669388138315 0.0841776939231776 no 3052 0.0858222423624257 995 8407 SGTC_2584 androsterone 48.74 µM -1.36872256355634 0.0838937782333888 no 3053 0.0855430072286364 942 2754130 A steroid. SGTC_3187 9109394 49.47 µM -1.37161413316578 0.0834350618876888 no 3054 0.0850917958709022 999 17098090 SGTC_1001 4048-4355 44.4 µM -1.37162507159383 0.083433330210309 no 3055 0.0850900923905937 994 21824233 SGTC_3234 9132280 49.47 µM -1.37466940507191 0.0829524268916573 no 3056 0.0846169802683774 998 17612295 SGTC_2179 6298986 200 µM -1.37468491456291 0.0829499822581923 no 3057 0.0846145750397099 955 738374 SGTC_917 harmaline 728.087 nM -1.37669044035787 0.0826343241118389 no 3058 0.0843039877864914 978 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1063 disulfiram 1.84 µM -1.37720222826072 0.0825539166384274 no 3059 0.0842248665623026 1011 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1319 1306-0155 43.7 µM -1.3785672074175 0.0823397515163028 no 3060 0.0840141165139166 1001 3122360 SGTC_159 3970-0959 50 µM -1.37888914723284 0.0822893002141308 no 3061 0.0839644674073161 990 6615653 SGTC_187 1488-2104 32.728 µM -1.38013080085414 0.0820949382594247 no 3062 0.0837731876649378 1009 2852859 SGTC_727 3032-0951 202 µM -1.38209490474556 0.0817881942341501 no 3063 0.0834712813837681 1011 3652836 SGTC_2204 7233102 200 µM -1.38355213258323 0.0815611704289856 no 3064 0.0832478169487156 983 2172480 SGTC_3111 9122088 49.47 µM -1.38585016712121 0.0812041220238008 no 3065 0.0828963300214296 993 16876704 SGTC_854 0422-0053 192 µM -1.3876038988304 0.0809324369812177 no 3066 0.0826288467962119 1015 3596728 SGTC_1874 staurosporine 7.6 µM -1.3880535465985 0.0808628889792666 no 3067 0.0825603702201486 990 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2057 5236571 38.335 µM -1.38972312989903 0.0806050456601213 no 3068 0.0823064841762517 993 54684039 YBR257W POP4 SGTC_1936 st074407 74.3 µM -1.39085098234963 0.0804312166983853 no 3069 0.082135309748092 1010 809813 SGTC_1257 0669-0121 16 µM -1.39469636756667 0.0798406798813862 no 3070 0.0815537103714507 993 4307855 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.39640167839594 0.0795798468299555 no 3071 0.0812967849840113 965 4000243 SGTC_2118 5526350 200 µM -1.3973477167507 0.0794354253965743 no 3072 0.0811545166210149 1008 743594 SGTC_1128 3448-9350 235 µM -1.39784929211591 0.0793589358244299 no 3073 0.081079164312436 996 619386 SGTC_1630 st005209 31.3 µM -1.39878101059666 0.0792169979900199 no 3074 0.0809393312108583 990 3367314 SGTC_2916 7875993 68.79 µM -1.4013542173601 0.0788259945886974 no 3075 0.0805540878511247 985 1299250 SGTC_2316 5844804 197.44 µM -1.40215199235001 0.0787050686622796 no 3076 0.0804349320131666 994 776813 SGTC_1103 duloxetine 36.1 µM -1.40436607608297 0.078370196589022 no 3077 0.0801049336684258 1026 60835 A selective serotonin reuptake inhibitor. SGTC_750 4073-0104 132 µM -1.40652605973445 0.0780445491118852 no 3078 0.0797839859421497 944 22330957 SGTC_801 0866-0028 10.1 µM -1.4099671799617 0.07752787450755 no 3079 0.0792746870668668 1011 6849771 SGTC_486 niguldipine 82 µM -1.41575379779413 0.076664892255006 no 3080 0.0784238005759007 1012 1236 A calcium channel blocker. SGTC_878 0828-0289 13.7 µM -1.41652231311828 0.0765508320847396 no 3081 0.0783113179808958 989 745350 YLR208W SEC13 SGTC_609 0986-0026 86.3 µM -1.41729469677342 0.0764363278921583 no 3082 0.0781983925129568 988 2848610 SGTC_1454 4239-0054 42.6 µM -1.4227407300157 0.0756326608169982 no 3083 0.0774056643659784 1009 1340767 SGTC_350 k064-0020 19.8 µM -1.42779421502604 0.0748926952046139 no 3084 0.0766755492130305 958 2790705 SGTC_2321 7390090 138.78 µM -1.43061416554015 0.0744821865955846 no 3085 0.0762704126839718 1025 649046 SGTC_3170 9103054 49.47 µM -1.43147675568585 0.0743569604715204 no 3086 0.0761468120586428 992 16432970 SGTC_2215 7188065 200 µM -1.43913460593435 0.0732522747258314 no 3087 0.075056194442207 1019 940217 SGTC_3083 9117465 49.47 µM -1.43951224678787 0.0731981246316576 no 3088 0.0750027213204099 1028 16420915 SGTC_901 1112-0062 60.1 µM -1.43978455677226 0.0731590969870876 no 3089 0.074964180853587 1004 1908457 SGTC_1668 st014914 51.6 µM -1.44607756031381 0.0722616087331275 no 3090 0.074077724421161 1025 2839556 SGTC_262 fenpropimorph 62.5 µM -1.44617632714595 0.0722475904770886 no 3091 0.0740638758544624 1042 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_92 0063-0024 660.874 µM -1.44783429980195 0.0720125807497397 no 3092 0.073831698799888 1042 3594437 SGTC_1222 0366-0074 1.18 µM -1.44821055106765 0.0719593306093445 no 3093 0.073779087328615 1024 286520 SGTC_2927 9011802 47.9 µM -1.45345809522096 0.0712197988860264 no 3094 0.073048303216584 1015 43912568 SGTC_1804 st050076 49.1 µM -1.45504894394152 0.0709967585253434 no 3095 0.0728278560907343 1031 3895976 SGTC_737 1950-0117 57.9 µM -1.45708739289771 0.0707117482780882 no 3096 0.0725461289864068 1015 5393513 SGTC_1705 st027868 56.3335 µM -1.45953896139724 0.0703701423006204 no 3097 0.0722084126201181 996 292948 SGTC_482 fipronil 114 µM -1.46196387496169 0.0700335001583295 no 3098 0.0718755547604739 1031 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_304 1310-0298 97 µM -1.464430735059 0.0696923074591312 no 3099 0.0715381477375675 1020 1550234 SGTC_3153 9100258 49.47 µM -1.46866527653267 0.0691096112639014 no 3100 0.0709618000340751 1006 25236848 SGTC_3199 9111318 49.47 µM -1.46932292631759 0.0690194528287062 no 3101 0.0708726106338896 1000 8548020 SGTC_1648 st011736 69.8 µM -1.4710318466972 0.0687855975821502 no 3102 0.0706412522560873 1027 2855514 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.47190571943127 0.0686662497917381 no 3103 0.0705231694569537 1014 6312947 SGTC_270 tamoxifen 5.46 µM -1.47191747147389 0.0686646458640114 no 3104 0.0705215824867597 1045 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_175 3793-3120 23.7 µM -1.47217456366764 0.0686295649549734 no 3105 0.070486872186436 1021 5322297 SGTC_1834 st055981 52.8 µM -1.47280887252824 0.0685430709605946 no 3106 0.0704012896238678 1014 471719 YDL150W RPC53 SGTC_3353 9151644 39.2805 µM -1.47395905267008 0.0683864475547943 no 3107 0.07024630820447 1022 4909158 SGTC_818 4072-2707 53.5 µM -1.47890792986882 0.0677156928978856 no 3108 0.0695824618392452 998 882871 SGTC_3124 9127567 49.47 µM -1.47895055565322 0.0677099376938408 no 3109 0.0695767650373181 1000 17592030 SGTC_139 0099-0334 718.624 µM -1.47979599631211 0.0675958669152666 no 3110 0.0694638487370587 1023 97690 SGTC_855 0428-0020 25 µM -1.4809010256435 0.0674469951674598 no 3111 0.0693164748468725 1013 6812414 SGTC_441 propafenone 146 µM -1.48262188013615 0.0672156629650588 no 3112 0.069087450261572 1016 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1052 3253-3998 198 µM -1.48299214804151 0.0671659686291122 no 3113 0.0690382484735227 1017 5450317 SGTC_970 1315-0089 19.5 µM -1.48557873771121 0.0668196097196223 no 3114 0.0686952912517881 1009 6811083 YLR033W RSC58 SGTC_185 k048-0037 25.491 µM -1.49412462871594 0.065685086746204 no 3115 0.0675715239058955 1020 6827589 SGTC_1515 3460-0031 42.1 µM -1.49486084868812 0.0655880516773129 no 3116 0.0674753809535358 1006 2876596 SGTC_1361 1608-0041 5.61 µM -1.49877166042406 0.0650744622057186 no 3117 0.0669664394712599 1015 X1361 SGTC_1037 k284-1091 78.7 µM -1.50391455178725 0.0644038268887384 no 3118 0.0663016848313759 1021 3334711 SGTC_2704 st078022 71.1 µM -1.50548142806238 0.0642005764201405 no 3119 0.0661001740554723 1016 54697681 SGTC_1520 flindersine 88 µM -1.50720710288467 0.0639773043956238 no 3120 0.0658787900985928 995 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1320 1313-0481 95.3 µM -1.5117331981189 0.0633945755161501 no 3121 0.0653008747755541 1011 6813365 YLR208W SEC13 SGTC_1723 st034307 2.5525 µM -1.51173526144185 0.0633943108113415 no 3122 0.0653006122195729 1004 867466 SGTC_89 0302-0250 142.109 µM -1.51204270606728 0.0633548781894675 no 3123 0.0652614993204512 1043 4203518 YLR208W SEC13 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.5149611289938 0.0629815136720316 no 3124 0.0648911241176852 1028 1273210 SGTC_2619 obliquin 87.91 µM -1.51600816392647 0.0628479812125966 no 3125 0.0647586440443693 999 6708593 A bioactive alkalod. YER133W GLC7 SGTC_59 0330-0160 1.33 µM -1.52136862317479 0.0621677935774495 no 3126 0.0640836791078523 1030 4293482 SGTC_2283 7944793 200 µM -1.52428562700398 0.0618000758476626 no 3127 0.0637186880002467 996 2970533 SGTC_871 0574-0004 149 µM -1.52522954983005 0.0616814491510117 no 3128 0.0636009263021306 1038 9551173 SGTC_3176 9106582 49.47 µM -1.52562018801223 0.0616324080737245 no 3129 0.0635522407299934 1019 17018027 SGTC_1698 5-fluorocytosine 1.055 µM -1.52577796726552 0.061612608954947 no 3130 0.0635325847905289 1009 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_299 1273-0059 1.44 µM -1.52887100286429 0.0612254778511473 no 3131 0.0631482130191793 988 2848077 SGTC_1714 st033236 13.627 µM -1.5292100201702 0.0611831615445521 no 3132 0.0631061936708701 1013 2916566 SGTC_2350 9023895 38.85 µM -1.53056126080105 0.0610147260811917 no 3133 0.0629389310817353 1010 2997209 SGTC_2753 fluvastatin 17.09 µM -1.5363672722028 0.0602951140735478 no 3134 0.0622241644179036 1031 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1415 3966-0071 78.1 µM -1.53681421554146 0.0602399953001671 no 3135 0.062169405636406 1020 2893185 SGTC_942 3253-1115 227 µM -1.54227266383122 0.0595700163524254 no 3136 0.0615036744275287 1019 46497897 SGTC_2839 9003951 25.97 µM -1.54256551305698 0.0595342372807183 no 3137 0.0614681155075545 1005 2990634 SGTC_1892 st058411 7.36 µM -1.54757329055787 0.0589250113684808 no 3138 0.0608625330884324 1032 3934738 SGTC_888 0916-0002 6.97 µM -1.54822715064663 0.0588458277384516 no 3139 0.0607838083580487 1035 2802138 YIL048W NEO1 SGTC_2341 7987486 176.74 µM -1.54898308127803 0.0587543872795757 no 3140 0.0606928936118845 1024 1258686 SGTC_2860 9025725 38.96 µM -1.55030889354213 0.0585942809687467 no 3141 0.0605336968702007 1043 40546248 SGTC_1658 st012944 20 µM -1.55180390404853 0.0584141532226101 no 3142 0.0603545757663174 1025 24207260 SGTC_1697 st025554 27.742 µM -1.55320760452782 0.0582454231654095 no 3143 0.0601867725851381 1026 1269519 SGTC_2685 mycophenolic acid 18.85 µM -1.55626753338709 0.0578789353747827 no 3144 0.0598222441675544 1014 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2902 5787006 60.46 µM -1.55763147945523 0.0577161606966473 no 3145 0.0596603159731522 1013 591003 SGTC_3321 9137793 26.8275 µM -1.5611781072811 0.0572945873367827 no 3146 0.0592408664949834 1027 4904192 SGTC_1519 esterone 74 µM -1.56526179953059 0.0568121807564352 no 3147 0.0587607681444578 1042 698 A steroid. SGTC_3014 9081533 49.47 µM -1.56810598051258 0.0564780916973736 no 3148 0.0584282005348016 1036 21367265 SGTC_2666 tannic acid 100 µM -1.56909297250853 0.0563625181452214 no 3149 0.0583131385136724 1015 16134267 A thiamine antagonist. SGTC_2439 5492030 7.2 µM -1.5759688676463 0.0555625384560885 no 3150 0.0575164890703238 1000 5722370 SGTC_2199 6590217 200 µM -1.58448615148961 0.0545840487375365 no 3151 0.0565415653110402 986 703109 SGTC_2887 9044784 58.44 µM -1.59150813880606 0.0537876340862567 no 3152 0.0557476326267395 1028 6465546 SGTC_2262 9014885 67.46 µM -1.59676400299981 0.0531975718373163 no 3153 0.0551591613864276 1051 6457424 SGTC_2802 7925815 54.55 µM -1.59743347412797 0.0531227819244793 no 3154 0.0550845578922384 1031 1262923 SGTC_1474 0330-0125 5.35 µM -1.59801399907488 0.0530579961379667 no 3155 0.0550199308008358 1055 X1474 SGTC_353 1988-1175 58.3 µM -1.60080238944094 0.0527476883473252 no 3156 0.0547103471093542 1000 2788357 SGTC_2025 5147754 141 µM -1.60231857675264 0.0525795638175779 no 3157 0.0545425899017484 980 315777 YLR208W SEC13 SGTC_1189 1431-2119 7.28 µM -1.60580720624525 0.0521943373710345 no 3158 0.0541581384079242 1036 3107275 SGTC_2108 5365811 200 µM -1.60728768017733 0.0520315373285327 no 3159 0.0539956377895063 1016 780283 SGTC_2661 dactinomycin 12.96 µM -1.60757226062856 0.0520002897666388 no 3160 0.0539644457813869 1035 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3258 9138477 49.47 µM -1.61407431473849 0.0512904034400095 no 3161 0.0532556539555774 1057 4970355 SGTC_1340 1486-1359 257 µM -1.62014177817631 0.0506349395865011 no 3162 0.0526009123654846 1022 4309068 SGTC_1251 0490-5699 265 µM -1.62819078210354 0.0497757268761554 no 3163 0.051742219368343 1043 3883818 SGTC_2751 anetholtrithion 17.25 µM -1.6320584721893 0.0493670175653606 no 3164 0.0513335844731729 1041 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1645 Cervolide 78 µM -1.63355143039909 0.0492099711234773 no 3165 0.0511765366408494 1036 23173 A fragrance. SGTC_2064 5220758 200 µM -1.63522737952058 0.0490341511956411 no 3166 0.0510006952813053 1029 788518 SGTC_2176 5809774 33.9695 µM -1.64154640097469 0.0483757459709446 no 3167 0.050342021685233 1002 2870539 SGTC_1381 2324-0066 62.1 µM -1.6473383668003 0.047778485763309 no 3168 0.049744257996987 1042 10885928 SGTC_2955 9076254 12.21 µM -1.6503595813042 0.0474692932978268 no 3169 0.0494347063860807 1029 16459619 SGTC_1169 aniline yellow 25.8 µM -1.65293399973517 0.0472070929717135 no 3170 0.0491721483049027 1035 6051 A DNA damaging agent. SGTC_3011 9081274 71.4286 µM -1.65477765372384 0.047020034161424 no 3171 0.0489848042280105 1043 6625322 SGTC_1957 st077035 62.4 µM -1.6588582766234 0.046608123904426 no 3172 0.0485721769463125 1053 705593 SGTC_1741 st038134 10.228 µM -1.66505081700266 0.0459885670457784 no 3173 0.0479513089416497 1040 1272587 SGTC_755 1995-0008 37.3 µM -1.66652767485126 0.0458417904894696 no 3174 0.0478041803824824 1040 689533 SGTC_2708 st078559 56 µM -1.66801784696584 0.0456940725006294 no 3175 0.047656091995144 1018 17250902 SGTC_3073 9114972 49.47 µM -1.67515654351342 0.0449917257813589 no 3176 0.0469517606661571 1040 41905075 SGTC_1460 k062-0059 9.15 µM -1.67762661714346 0.0447507386561898 no 3177 0.0467100066370492 1026 1373085 SGTC_615 k087-0205 167 µM -1.67992752787172 0.0445271916532834 no 3178 0.0464857085460291 1039 9642773 SGTC_1483 3453-0561 55.9 µM -1.68239157129647 0.0442887938183364 no 3179 0.0462464673667555 1034 4546991 SGTC_519 k048-0011 62.8 µM -1.68445709875857 0.044089746225368 no 3180 0.0460466819350262 1031 6836379 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.68531864378096 0.0440069356250864 no 3181 0.0459635552915972 1015 4330530 SGTC_405 ebelactone b 50 µM -1.68632824491239 0.0439100537201285 no 3182 0.0458662968467963 1039 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1818 st052136 56.3 µM -1.68985521699651 0.0435729529110117 no 3183 0.0455278284942604 1010 674169 SGTC_973 1325-0077 65.9 µM -1.69669225286852 0.0429254329130036 no 3184 0.0448774290541189 1059 2835149 SGTC_1782 st039423 80.636 µM -1.71255747190448 0.0414528103306808 no 3185 0.043396991448175 1056 2068169 SGTC_1737 st035557 69.7 µM -1.71741928623194 0.0410098178205878 no 3186 0.0429512951500772 1020 5716916 SGTC_3002 9075603 71.4286 µM -1.71772084569117 0.0409824676658048 no 3187 0.0429237726125206 1032 20105405 SGTC_2525 harmine 47.85 µM -1.72250928750695 0.0405501557309523 no 3188 0.0424886509155622 1035 5280953 A monoamine oxidase inhibitor SGTC_1471 k673-0312 37 µM -1.72426248613699 0.0403928015767169 no 3189 0.042330234129118 1047 24099884 SGTC_2725 haloperidol 53.21 µM -1.72489004610255 0.0403365970789262 no 3190 0.0422736448767636 1035 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3133 9127736 49.47 µM -1.72637696115407 0.0402036819170665 no 3191 0.0421398089032393 1028 27243420 SGTC_1594 piperine 70.1 µM -1.72673032711758 0.0401721469526694 no 3192 0.042108053211464 1051 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2576 guaiol 23.12 µM -1.73146094697978 0.0397519105782537 no 3193 0.0416847922228633 1020 227829 SGTC_2602 kawain 100 µM -1.73359476063353 0.0395635301538904 no 3194 0.041495005378624 1029 5369129 SGTC_72 0744-0168 198.391 µM -1.73562423033162 0.0393850358754936 no 3195 0.0413151493722646 1045 677577 SGTC_2065 5221596 34.26 µM -1.73742471501491 0.0392272300878806 no 3196 0.04115611596431 1032 788581 SGTC_2544 sphondin 68.51 µM -1.74131121488879 0.0388883468944967 no 3197 0.0408145207203476 1019 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2769 toremifene 3.73 µM -1.74594229193423 0.0384876575139943 no 3198 0.0404104900040087 1048 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_826 1683-5028 118 µM -1.74835365370468 0.0382803579752702 no 3199 0.0402014039599099 1045 722377 SGTC_3181 9108277 49.47 µM -1.7591203404624 0.0373658490907968 no 3200 0.0392785353704668 1048 17097298 SGTC_702 1488-0190 94 µM -1.76039541697136 0.0372587374976656 no 3201 0.0391703929381706 1048 949357 SGTC_1801 st050089 28.441 µM -1.76314513675086 0.0370286036177639 no 3202 0.0389380070821855 1042 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_211 3455-0679 143.504 µM -1.767880051414 0.0366350454120239 no 3203 0.038540479203234 1039 748649 SGTC_3355 9151058 44.0485 µM -1.76977638367132 0.0364783880898923 no 3204 0.0383821997657099 1066 17015728 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.77363942341532 0.0361609553227408 no 3205 0.0380614061418545 1040 6708514 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.7759041669131 0.0359759114243846 no 3206 0.0378743570231434 1023 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2862 9027634 71.43 µM -1.77672785920972 0.0359088031872038 no 3207 0.037806513137099 1028 5012562 SGTC_3164 9100705 49.47 µM -1.77783044660625 0.0358191332287984 no 3208 0.0377158531722427 1034 17174235 SGTC_923 1900-2434 73.3 µM -1.77866282414805 0.0357515601921197 no 3209 0.037647528762337 1039 5910570 SGTC_300 r073-0011 5.04 µM -1.78009110890293 0.0356358543944152 no 3210 0.0375305257141166 1067 2735780 SGTC_2700 st077718 96.8 µM -1.78197514564062 0.0354836976447759 no 3211 0.0373766424572546 1053 904970 SGTC_2665 lovastatin 100 µM -1.78503370076607 0.0352378201776769 no 3212 0.0371279253325588 1056 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2026 5148700 152 µM -1.7923119028171 0.0346583417904222 no 3213 0.0365415088461028 1063 79838 SGTC_3283 9109332 35.8195 µM -1.79885965508345 0.0341437300499775 no 3214 0.0360204419674651 1026 17027281 SGTC_144 4161-2749 112.381 µM -1.80013763708037 0.0340440251358671 no 3215 0.0359194539896315 1042 797501 YMR168C CEP3 SGTC_448 monastrol 171 µM -1.80981256691101 0.0332969541075142 no 3216 0.0351624292160585 1058 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1521 st012942 49.4 µM -1.81706479464184 0.032745854821469 no 3217 0.0346035962995026 1048 24207259 SGTC_2657 nystatin 74.44 µM -1.82523280953066 0.032134192089218 no 3218 0.0339829523237789 1049 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1465 k213-0056 144 µM -1.82792068033552 0.0319349850581484 no 3219 0.0337807284227753 1024 24048857 YMR208W ERG12 SGTC_1967 st070177 51.4 µM -1.83026403899683 0.0317621441972705 no 3220 0.0336052329795601 1064 5729214 SGTC_1702 st027038 51 µM -1.83563828003377 0.0313686697522979 no 3221 0.0332055858544362 1062 5521182 SGTC_1987 st072290 61.9 µM -1.83599229170512 0.0313428929487422 no 3222 0.0331793983470494 1050 54697379 SGTC_2920 7982904 15.77 µM -1.83927784682506 0.0311044950455794 no 3223 0.0329371648523963 1056 6456808 SGTC_2785 7756463 72.73 µM -1.84473501501332 0.0307118424475978 no 3224 0.0325380473452183 1052 2201551 SGTC_2565 isoliquiritigenin 100 µM -1.84611543527086 0.0306131718755442 no 3225 0.032437723059822 1025 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2533 agelasine 13.65 µM -1.84616996355537 0.030609279663927 no 3226 0.0324337653735385 1043 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.84622807638701 0.0306051320396186 no 3227 0.0324295479578252 1065 75037 A free radical scavenger. SGTC_956 1185-0240 191 µM -1.85268722555573 0.0301470226595271 no 3228 0.0319636010231414 1060 1416193 SGTC_2524 avocatin b 10.57 µM -1.85720741627947 0.0298298249161441 no 3229 0.0316408251372942 1066 6710748 SGTC_2172 5754775 163.918 µM -1.86456600084928 0.0293193720496379 no 3230 0.0311211311086988 1047 2263357 SGTC_798 1287-0182 476 µM -1.87089566273287 0.0288861170131316 no 3231 0.0306797721588399 1069 1649755 SGTC_2763 lisinopril 49.32 µM -1.88036452685751 0.0282479340207809 no 3232 0.0300292073114065 1042 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_285 1486-1325 46 µM -1.88404488859845 0.0280030726136388 no 3233 0.0297794519345036 1061 22310230 SGTC_1297 1068-0111 14.1 µM -1.88567724647623 0.0278950360199754 no 3234 0.0296692304400061 1049 767057 SGTC_3278 9139605 49.47 µM -1.88682038014264 0.0278195853193542 no 3235 0.0295922444918542 1051 7958859 SGTC_375 3970-0961 9.27 µM -1.8888559164243 0.0276856539696171 no 3236 0.0294555689151077 1049 2898222 SGTC_1906 st060206 94.7 µM -1.9026239832544 0.0267938033808649 no 3237 0.0285448136958796 1039 5133468 SGTC_955 1216-0110 33 µM -1.91235049851074 0.0261783176350516 no 3238 0.0279156263578268 1069 3619719 SGTC_310 1273-0058 1.06 µM -1.91337072304999 0.0261144492539269 no 3239 0.0278503048244578 989 2734232 SGTC_780 0109-0199 192 µM -1.91720712302567 0.0258754470540179 no 3240 0.0276058117524172 1055 610414 SGTC_2595 hexamethylquercetagetin 100 µM -1.92379481162958 0.0254693138760125 no 3241 0.0271901540178536 1056 386331 SGTC_2970 9090938 41.86 µM -1.92653049043822 0.0253022342026261 no 3242 0.0270190842330421 1045 17217104 SGTC_738 1315-0003 72.4 µM -1.94774490764945 0.0240374974932234 no 3243 0.0257227468955092 1072 6251474 SGTC_800 3448-7362 155 µM -1.94903474201756 0.0239623458242915 no 3244 0.0256456379500327 1069 15991913 SGTC_2703 st077852 53.4 µM -1.95172930649154 0.0238059851028627 no 3245 0.0254851756282292 1048 6281836 SGTC_793 0488-0545 106 µM -1.95895574176358 0.0233908774673969 no 3246 0.0250589850710431 1067 292548 SGTC_612 0302-0167 22.4 µM -1.96665806940766 0.0229551558891957 no 3247 0.0246113219903526 1066 235821 SGTC_2808 7946468 45.46 µM -1.96756973808112 0.0229040381102072 no 3248 0.0245587822607131 1054 2970879 SGTC_2022 5136654 200 µM -1.97823580878339 0.0223130762773237 no 3249 0.0239510554113052 1062 1713771 SGTC_1926 methyl fluorone black 53.6 µM -1.97932372879425 0.0222535287005001 no 3250 0.023889784829088 1014 72721 Reacts with homocysteine. SGTC_2827 7993847 71.43 µM -1.98216261168936 0.0220987728575107 no 3251 0.023730521880301 1051 2985692 SGTC_636 0kpi-0074 126 µM -1.98476664044699 0.0219576193139651 no 3252 0.0235852203094976 1060 616434 SGTC_1835 st008666 49.2 µM -1.99020585339003 0.0216652367217362 no 3253 0.0232841318935348 1060 690455 SGTC_2180 6301957 200 µM -1.99454082247029 0.0214345740866053 no 3254 0.0230464916876869 1059 845462 SGTC_3117 9124945 49.47 µM -1.99750901751833 0.0212778374093063 no 3255 0.0228849579309697 1064 17592065 SGTC_1217 1183-1422 255 µM -2.00177913290407 0.0210540532922959 no 3256 0.0226542455895092 1060 2849664 SGTC_2517 totarol 10 µM -2.00336727104782 0.0209713332910242 no 3257 0.0225689408770376 1055 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1872 amphotericin b 148 nM -2.00350579190755 0.0209641313324621 no 3258 0.0225615132723161 1062 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2220 6782180 200 µM -2.010917593436 0.0205818187532688 no 3259 0.0221670808523202 1062 833803 SGTC_1286 0929-0070 131 µM -2.01153199207859 0.0205503938837485 no 3260 0.0221346473177966 1065 1420408 SGTC_977 1348-1378 135 µM -2.01300314477639 0.0204753134611854 no 3261 0.0220571492597217 1056 X977 SGTC_2000 st075254 36.4 µM -2.02162622356954 0.0200398924988793 no 3262 0.0216074904125249 1056 17234175 SGTC_633 0437-0093 97.7 µM -2.02549141469886 0.0198472844895884 no 3263 0.0214084645741999 1063 2831118 SGTC_1784 st039334 36.3 µM -2.02558401744168 0.0198426893001745 no 3264 0.0214037153621996 1058 3496984 SGTC_447 ml7 120 µM -2.02890783404444 0.0196783496628595 no 3265 0.0212338393455158 1084 4216 Selective myosin light chain kinase inhibitor. SGTC_1873 rapamycin 2 nM -2.03278157410367 0.0194882797053376 no 3266 0.0210372977566395 1053 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1376 2910-0861 41.3 µM -2.03674704061514 0.019295326582363 no 3267 0.020837698943917 1074 1112859 SGTC_867 0518-0118 155 µM -2.04196935946813 0.0190436960238411 no 3268 0.0205772853977911 1057 6848158 SGTC_817 1391-0715 46 µM -2.05122289687458 0.0186046777395634 no 3269 0.0201226225425767 1055 1353946 SGTC_251 melphalan 456.522 µM -2.05350957792614 0.0184975273876474 no 3270 0.0200115908917518 1086 460612 A DNA alkylator. SGTC_2674 ligustilide 100 µM -2.06916978259922 0.0177777451108023 no 3271 0.0192650786113154 1078 5319022 A signalling regulator. SGTC_1252 0493-0875 34.8 µM -2.07007162320044 0.0177370321423279 no 3272 0.0192228188891177 1055 3960963 SGTC_2474 5321570 43.32 µM -2.074853741247 0.0175224736290668 no 3273 0.0190000460362626 1078 2841384 SGTC_3060 1327-0027 12.5 µM -2.07664975264832 0.0174424665968959 no 3274 0.0189169486830242 1051 16000455 YPR107C YTH1 SGTC_250 brefeldin a 552.239 µM -2.07993819615021 0.0172967843909138 no 3275 0.0187656010081961 1083 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1459 k035-0031 35.7 µM -2.08358771426938 0.0171363241711315 no 3276 0.018598842746037 1043 3877128 YMR208W ERG12 SGTC_556 4058-0063 51.5 µM -2.08430757739151 0.0171048242399606 no 3277 0.018566099270255 1078 6615692 SGTC_1557 sumaresinolic acid 42.3 µM -2.09423899063332 0.0166752691872456 no 3278 0.0181193480275045 1065 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1107 amlodipine 47 µM -2.10322631124195 0.0162945369719653 no 3279 0.0177229956741507 960 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3129 9127257 49.47 µM -2.11496483314887 0.0158084871615857 no 3280 0.0172164723454537 1067 837894 SGTC_372 0155-0182 15.9 µM -2.11596130967378 0.0157678052560155 no 3281 0.0171740491536517 943 771486 SGTC_1700 st030840 7.9285 µM -2.11666407395201 0.015739168398816 no 3282 0.0171441839704395 1082 5499307 SGTC_1165 k072-0275 30.3 µM -2.12778019702485 0.0152920985060566 no 3283 0.0166776560016726 1071 6153523 YGL055W OLE1 SGTC_3185 9108267 49.47 µM -2.14989099559038 0.0144351880645256 no 3284 0.0157819190252322 1080 4910486 SGTC_884 0851-0618 334 µM -2.15760639340262 0.0141460654402483 no 3285 0.0154792236010917 1057 9642473 SGTC_2434 5670830 169.91 µM -2.15971789608485 0.0140678150886606 no 3286 0.015397257466943 1068 1549830 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.16605738524611 0.0138351168230546 no 3287 0.0151534010436256 1072 688667 SGTC_1852 st056254 31.4 µM -2.16928461706585 0.0137179379098702 no 3288 0.0150305411887756 1079 442583 SGTC_1505 k297-0037 20.6 µM -2.17801153496867 0.0134053475249853 no 3289 0.0147025889949904 1082 4089396 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.21348732685327 0.0121971365312024 no 3290 0.0134320330034801 1056 5379071 SGTC_921 1561-0023 372 µM -2.21623547199449 0.0121076098646128 no 3291 0.0133376898545838 1068 24050882 SGTC_335 4077-0256 27.6 µM -2.21671531513375 0.0120920365112328 no 3292 0.0133212757799448 1057 3121989 SGTC_2463 5473429 200 µM -2.22299978841563 0.0118896709341171 no 3293 0.0131079071200614 1074 5399405 SGTC_383 2324-0395 7.37 µM -2.22558399076304 0.0118073136349898 no 3294 0.0130210297547772 1021 3146421 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.23033753672611 0.0116571125443856 no 3295 0.0128625214871858 1075 16725076 SGTC_2523 spermine 47.74 µM -2.24948263004468 0.0110688422318174 no 3296 0.0122409033580546 1082 1103 A DNA binding polyamine. SGTC_2976 9009005 19.48 µM -2.25672972537092 0.0108529939546028 no 3297 0.0120124841239891 1057 2993148 SGTC_1324 1418-0026 34.4 µM -2.26156867246403 0.0107109182960621 no 3298 0.0118620326872869 1080 1372513 SGTC_3055 9094636 49.47 µM -2.26812249623104 0.0105210761154646 no 3299 0.0116608707913266 1070 25236176 SGTC_377 3970-0964 33.1 µM -2.2698908693631 0.0104703572715333 no 3300 0.0116071026236864 1074 16481235 SGTC_2263 7948595 193.29 µM -2.28974902805558 0.00991527442141457 no 3301 0.011017934751743 1079 2971371 SGTC_600 1495-0418 41.6 µM -2.30175894842646 0.00959218591265568 no 3302 0.0106743849002133 1077 5377768 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.31106911183986 0.00934809497628634 no 3303 0.0104145188905692 1073 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1164 k060-0068 93.7 µM -2.32420013567802 0.00901307274117145 no 3304 0.0100573850237011 1087 5963676 SGTC_2811 7967822 32.47 µM -2.33450850078766 0.00875748265783054 no 3305 0.00978455573488115 1067 2232244 SGTC_1343 1487-0095 224 µM -2.34321838480826 0.00854650139198422 no 3306 0.00955909449724814 1078 4560101 YGL055W OLE1 SGTC_1637 st007924 17.4 µM -2.35252320973726 0.00832604830959967 no 3307 0.00932326302264257 1062 683336 SGTC_2705 st078069 42.8 µM -2.37240145957637 0.0078717473696211 no 3308 0.00883643827862518 1081 1530061 SGTC_2589 lobaric acid 100 µM -2.3877951407739 0.00753506390754415 no 3309 0.00847489348017176 1073 73157 A novel microtubule depolymerizer. SGTC_2205 7238770 200 µM -2.39907429440366 0.00729648731145526 no 3310 0.0082182897093921 1085 279867 SGTC_2745 rifampicin 24.3 µM -2.41012761849381 0.00706917380894617 no 3311 0.00797347064743413 1090 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_976 1348-1067 47.6 µM -2.42046510698558 0.00686226045163821 no 3312 0.00775033341922752 1083 5310671 YGL099W LSG1 SGTC_886 0866-0150 153 µM -2.42309570923401 0.00681046813979187 no 3313 0.00769443585598975 1080 271463 SGTC_2017 5132927 60.65 µM -2.45970183693415 0.00612476814924093 no 3314 0.00695262423244977 1079 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1662 st014054 52 µM -2.48943435996501 0.00561359270831804 no 3315 0.0063973271185859 1092 2838777 SGTC_1488 4013-0813 75.9 µM -2.49553065257094 0.00551358943694237 no 3316 0.00628844442334246 1090 2910057 SGTC_1447 4239-0816 81.9 µM -2.49747822764294 0.00548197680770255 no 3317 0.00625400729106423 1078 1341554 SGTC_252 miconazole 1.30953 nM -2.53483167847864 0.00490604760550895 no 3318 0.0056250684267711 1064 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_684 1140-0066 328 µM -2.55665858839536 0.00459505506130301 no 3319 0.00528414428165033 1087 6813534 SGTC_2357 9067248 200 µM -2.58433462728561 0.00422608513179057 no 3320 0.00487835407004606 1079 9150235 SGTC_1429 4049-0205 9.46 µM -2.60955670488803 0.00391314949085685 no 3321 0.00453298096315842 1086 22774478 SGTC_1896 st058441 89 µM -2.62054958437778 0.00378337785489841 no 3322 0.00438940813603384 1082 688759 SGTC_3142 9086498 49.47 µM -2.67595426929994 0.00318624016429668 no 3323 0.00372584060123906 1063 25236367 SGTC_2604 4'-hydroxychalcone 11.32 µM -2.67635490367144 0.00318225011963987 no 3324 0.0037213892440223 1085 5282362 SGTC_2351 9026858 72.31 µM -2.68089754086245 0.00313732207373111 no 3325 0.00367124967193512 1082 1409300 SGTC_905 2-aminofluorene 215 µM -2.69849068996734 0.00296865917990442 no 3326 0.00348273430983011 1083 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2610 ononetin 44.17 µM -2.72155386476267 0.00275994436583564 no 3327 0.00324878975242513 1086 259632 SGTC_1064 honokiol 6.76 µM -2.72949857951961 0.00269117370953103 no 3328 0.00317153611851797 1087 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1504 k297-0033 30 µM -2.7361848601645 0.00263449947177414 no 3329 0.00310780489394631 1074 4388117 SGTC_2963 9082507 9 µM -2.76116313164267 0.00243219073109581 no 3330 0.00287979498589085 1092 16459611 SGTC_1695 st026914 34.495 µM -2.77030217983325 0.0023617552829725 no 3331 0.00280021540268998 1094 3289191 SGTC_1970 st070122 35.8 µM -2.79793541644493 0.00215987170388896 no 3332 0.0025715197566044 1089 102928 SGTC_2015 5119600 184 µM -2.8004623601115 0.00214221443540405 no 3333 0.00255147290945644 1079 2828786 SGTC_936 3005-4620 401 µM -2.82240260610663 0.001994320142485 no 3334 0.00238326486380773 1083 777207 SGTC_1345 1488-0192 31.4 µM -2.83780558371966 0.00189609791658033 no 3335 0.00227124207922682 1087 658348 SGTC_130 0136-0219 337.655 µM -2.90926264678 0.0014954618473839 no 3336 0.0018114118069614 1087 234244 SGTC_379 3970-0972 5.9 µM -2.96428293419067 0.00124139224164344 no 3337 0.00151694599605865 1094 2898042 YBL034C STU1 SGTC_2620 irigenin 100 µM -2.96842848861594 0.00122394915944764 no 3338 0.00149663371331111 1079 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_630 4356-0227 183 µM -3.03846670717445 0.000961204923204929 yes 3339 0.00118892688748318 1094 779312 SGTC_2168 5727979 200 µM -3.17382130802898 0.000594292866076971 yes 3340 0.000752231407015276 1089 695210 SGTC_1685 st024049 53.0905 µM -3.20425075586706 0.000532065853478404 yes 3341 0.000677072404420052 1093 1941139 SGTC_1676 st018489 23.4 µM -3.21201269286335 0.000517187941803957 yes 3342 0.000659042758344161 1089 3696235 SGTC_3216 9129716 49.47 µM -3.33012349108455 0.000333426268386596 yes 3343 0.000434037375341493 1088 8056934 SGTC_1696 st025591 34.7925 µM -3.33171113050598 0.000331433078262657 yes 3344 0.000431568997938821 1095 2787147 SGTC_2925 9010536 32.5 µM -3.4008950362904 0.000254600282855103 yes 3345 0.000335828061350649 1044 2994177 SGTC_3263 9137018 49.47 µM -3.46141767994952 0.000201349783737238 yes 3346 0.000268669213043237 1085 43844957 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -3.49910936827125 0.000173651540038904 yes 3347 0.000233407530498434 1087 6857784 SGTC_2288 7946289 167.31 µM -3.51771528219749 0.000161332851451045 yes 3348 0.000217639558072968 1090 1246052 SGTC_948 3448-0295 75.3 µM -3.63979833172424 9.86935109059681e-05 yes 3349 0.000136425825788017 1091 678569 SGTC_1907 st060210 83.7 µM -3.67491775299585 8.54439989029142e-05 yes 3350 0.00011896302389304 1085 688793 SGTC_1266 0828-0227 32.9 µM -3.68085083344662 8.33779723369306e-05 yes 3351 0.000116228486634632 1092 3913820 SGTC_2780 5215298 71.43 µM -3.99793147936408 2.14008837441766e-05 yes 3352 3.19492206429315e-05 1094 2834131 SGTC_1254 0550-0035 264 µM -4.05057798204427 1.69075055715685e-05 yes 3353 2.55456395374171e-05 1094 15121435 SGTC_1684 st024538 14.6195 µM -4.19789789707496 8.61306297656091e-06 yes 3354 1.34702018979998e-05 1095 6732859 SGTC_2837 9008476 45.46 µM -4.21575315280881 7.92506131180182e-06 yes 3355 1.24472975906938e-05 1095 2992805 SGTC_2960 9079389 5.97 µM -5.03931483183004 1.1946990778457e-07 yes 3356 2.33600699009737e-07 1094 16457355