SGTCid condition conc unit MED1|YPR070W.score MED1|YPR070W.strain.pval MED1|YPR070W.strain.significant MED1|YPR070W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_682 0kpi-0099 17 µM 10.8357998878509 3.74156445313796e-22 yes 1 1.16460414253039e-27 5 1714895 YML126C ERG13 SGTC_1687 st020778 55.3625 µM 9.91969228955704 7.16983739882152e-19 yes 2 1.70904149629286e-23 50 4259299 SGTC_1597 7-benzyloxygramine 47.5 µM 7.22387374895006 7.51757806963935e-11 yes 3 2.52635849860333e-13 33 260807 SGTC_1465 k213-0056 144 µM 7.16704282529345 1.04457443073963e-10 yes 4 3.83175326452599e-13 2 24048857 YMR208W ERG12 SGTC_1712 st032288 53.4 µM 7.0310941501606 2.27149891823288e-10 yes 5 1.02460081070183e-12 55 2883011 SGTC_178 4092-0806 87.505 µM 6.65793183896705 1.78108789257131e-09 yes 6 1.38853750622563e-11 30 2169044 SGTC_2165 5727197 32.143 µM 6.42981601719083 5.95094620292108e-09 yes 7 6.38792430830153e-11 8 1361712 SGTC_762 1165-0429 115 µM 5.87356788886248 9.54232128967477e-08 yes 8 2.13257122659566e-09 2 5967793 SGTC_1760 st045453 10.4495 µM 5.5192900484614 4.94059882046193e-07 yes 9 1.70185993434536e-08 94 3323419 YIL048W NEO1 SGTC_788 1182-0090 188 µM 5.35327526567768 1.03316802604729e-06 yes 10 4.31881477760694e-08 46 5715185 SGTC_528 3492-0019 172 µM 5.12833984727329 2.71522358565187e-06 yes 11 1.46154206567511e-07 150 2869262 SGTC_1877 wortmannin 25 µM 5.01215335563596 4.4060870712217e-06 yes 12 2.69121398994457e-07 63 312145 A covalent inhibitor of PI 3-kinase. SGTC_1754 st042065 16.137 µM 4.88080011789574 7.52346187782214e-06 yes 13 5.28281445907481e-07 133 1126236 YIL048W NEO1 SGTC_94 0334-0113 514.748 µM 4.81513827296925 9.78266227307993e-06 yes 14 7.35489988272508e-07 9 6795178 SGTC_1943 st076331 65.2 µM 4.80578120274912 1.01529759543779e-05 yes 15 7.70742034631467e-07 6 24208415 SGTC_1788 fluconazole 20 µM 4.77294533713092 1.15609237575425e-05 yes 16 9.07755396334297e-07 46 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2366 9070441 60.58 µM 4.658467923018 1.80661909368368e-05 yes 17 1.59285716917097e-06 17 6837235 SGTC_1304 1165-0502 251 µM 4.6136723892306 2.14568833844204e-05 yes 18 1.97807920706563e-06 48 767425 SGTC_582 0987-0078 156 µM 4.5314169681665 2.93110570666102e-05 yes 19 2.92946826412397e-06 47 1625765 SGTC_115 0527-0192 112.043 µM 4.49487167909753 3.3613252726358e-05 yes 20 3.48059565690016e-06 51 4233931 SGTC_1069 diphenylcyclopropenone 8.49 µM 4.47681846796669 3.59527918198678e-05 yes 21 3.7881808970167e-06 25 65057 A dermal irritant. YDR527W RBA50 SGTC_686 1319-0111 510 µM 4.46709673423984 3.72756252882288e-05 yes 22 3.96441414945916e-06 18 4562600 SGTC_789 1309-1135 70.6 µM 4.44394226526467 4.06140172828221e-05 yes 23 4.41626579110257e-06 17 3092424 SGTC_2752 diclazuril 33.15 µM 4.35671572603276 5.59039550948359e-05 yes 24 6.6014281057781e-06 98 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1803 st050068 52.4 µM 4.22420954743389 8.98506103350841e-05 yes 25 1.19890435410341e-05 161 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1019 4262-0212 3.4 µM 4.17577774510771 0.000106518486182779 yes 26 1.48484831997942e-05 56 4677213 SGTC_960 1222-0186 7.7 µM 4.16447442774977 0.000110806172778089 yes 27 1.56035300050309e-05 28 3126296 SGTC_2021 4019055 173 µM 4.14732935586824 0.00011762017025953 yes 28 1.68188003287582e-05 111 44827708 YER133W GLC7 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 4.07732899764143 0.000149731944791075 yes 29 2.2778005605892e-05 18 115019 SGTC_86 0417-1630 471.922 µM 4.0522642400949 0.000163104847764476 yes 30 2.5362164385914e-05 145 3634867 SGTC_2359 9039622 200 µM 3.99260865948199 0.000199561525430168 yes 31 3.26751853784079e-05 23 6463596 SGTC_1160 4092-0570 10.5 µM 3.96116428176441 0.000221714646615975 yes 32 3.72925966188455e-05 38 4994975 SGTC_85 0868-0259 160.055 µM 3.95676636730228 0.000224989999695162 yes 33 3.79855835026349e-05 9 83173 SGTC_1801 st050089 28.441 µM 3.95544916359478 0.000225979742491834 yes 34 3.81954958067788e-05 118 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_149 3970-0822 46.1 µM 3.9053030985001 0.000266825356481163 yes 35 4.70536788086243e-05 100 3114250 YBL034C STU1 SGTC_1780 st038448 24.544 µM 3.89587695565876 0.000275233012750784 yes 36 4.89220276580389e-05 19 728868 YDL195W SEC31 SGTC_2036 5160441 105 µM 3.83299566307267 0.000337948476425056 yes 37 6.32960930851224e-05 84 134534 YIL048W NEO1 SGTC_2429 5902844 64.44 µM 3.78421206495011 0.000395493214152149 yes 38 7.70981534031829e-05 31 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1860 st056228 74.6 µM 3.76071509878031 0.000426342243474755 yes 39 8.47141562953352e-05 29 688679 SGTC_2651 TUB2.036 5 µM 3.66792413555379 0.000571276275153412 yes 40 0.000122263854849871 183 15992207 YFL037W TUB2 SGTC_757 1066-0008 322 µM 3.666376834967 0.000574039848961074 yes 41 0.000123005661612475 25 6842497 SGTC_227 fluconazole 33.516 µM 3.66607681783876 0.00057457712615408 yes 42 0.000123149983594286 101 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.64531513043927 0.000612906864561251 yes 43 0.000133532171152649 59 688788 SGTC_706 4262-0057 46.9 µM 3.62819118476123 0.000646283259823848 yes 44 0.000142706939689806 47 883298 SGTC_1800 st050079 29.0735 µM 3.60964482256562 0.000684318945735087 yes 45 0.000153308275442563 148 3645560 SGTC_1511 0906-3109 28.5 µM 3.58032100572098 0.000748690650046995 yes 46 0.000171586179060488 68 2882180 SGTC_562 3772-2733 112 µM 3.53551589526849 0.000857885900372699 yes 47 0.000203489879893031 99 2876874 YIL048W NEO1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 3.50589820590489 0.00093791479486662 yes 48 0.000227534611801823 86 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2072 5231554 129 µM 3.44315378254763 0.00113057174494324 no 49 0.000287486131734299 20 789545 SGTC_849 0386-0493 241 µM 3.41648703588884 0.00122293092070061 no 50 0.000317173420453572 35 726119 SGTC_2153 5569715 200 µM 3.41197630986663 0.00123921970699988 no 51 0.000322468589708256 26 2054701 SGTC_804 1595-0054 20.9 µM 3.38356416256134 0.0013464653514209 no 52 0.000357757433445195 61 761523 Stimulates phospholipase C. SGTC_21 0849-0113 22.993 µM 3.36488025516849 0.00142154344077007 no 53 0.000382884424924703 53 1560156 SGTC_2610 ononetin 44.17 µM 3.35710238451562 0.00145390923841377 no 54 0.000393819701849038 71 259632 SGTC_1335 1486-0900 202 µM 3.33896643294447 0.00153200646281122 no 55 0.000420453624665788 56 X1335 SGTC_698 k064-0052 127 µM 3.24775513682755 0.00198593316218226 no 56 0.00058159663024622 10 5088751 SGTC_1189 1431-2119 7.28 µM 3.2324209100987 0.00207326078455702 no 57 0.000613730543875323 62 3107275 SGTC_61 0978-8327 98.565 µM 3.21338485181649 0.00218651140263959 no 58 0.000655901931304061 60 6150059 YHR072W ERG7 SGTC_1638 st008370 60.6 µM 3.18808130808188 0.00234572650146824 no 59 0.000716101289081437 55 24207134 SGTC_263 alizarin 107.927 µM 3.18755756422881 0.00234913012702966 no 60 0.000717399475110165 110 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2896 9052656 71.43 µM 3.17254864850583 0.00244858756943624 no 61 0.000755536202954191 183 6469436 SGTC_673 1082-0474 110 µM 3.15742400016546 0.00255264999728027 no 62 0.000795848607493824 109 3098046 SGTC_814 3342-0569 96 µM 3.14684316027822 0.00262780854320904 no 63 0.000825217328103351 59 4346283 SGTC_1468 k284-1086 134 µM 3.14078261361219 0.00267175320565785 no 64 0.000842485250993587 88 15996457 SGTC_221 trifluoperazine 10.304 µM 3.12293796335509 0.00280502401359426 no 65 0.000895277423791965 266 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_871 0574-0004 149 µM 3.10229008616125 0.00296669413156986 no 66 0.0009601484157432 88 9551173 SGTC_350 k064-0020 19.8 µM 3.07054950829144 0.00323163167601458 no 67 0.00106832629919202 59 2790705 SGTC_173 1273-0061 2.693 µM 3.04539839256497 0.00345647978034229 no 68 0.00116186139880705 230 2847414 YPL266W DIM1 SGTC_2882 9058044 58.44 µM 3.03529191560735 0.00355072023595763 no 69 0.00120151489032672 54 18076804 SGTC_105 0111-0055 734.78 µM 3.02883434741383 0.00361213702782824 no 70 0.00122749627665988 37 5179370 SGTC_2135 5326629 150.42 µM 2.99185751538242 0.00398253301212461 no 71 0.00138642824152523 78 5020077 SGTC_1400 3771-8998 51.5 µM 2.9755337619558 0.00415660629816863 no 72 0.00146239576770127 34 670767 SGTC_11 0438-0307 1.3 µM 2.97395720435508 0.00417377367596935 no 73 0.00146993036924768 47 4011476 SGTC_294 k038-0071 157 µM 2.95906567289085 0.00433908549163412 no 74 0.00154286666888009 120 24152826 SGTC_676 falcarinol 140 µM 2.95596971815899 0.00437417985310049 no 75 0.00155843845530198 102 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1481 3346-2004 36 µM 2.95294086210493 0.00440875884229005 no 76 0.00157381128548963 37 2770522 SGTC_96 0929-0093 37.281 µM 2.94675432828858 0.00448014731389765 no 77 0.00160564110513067 51 6991579 SGTC_265 mycophenolic acid 32.932 µM 2.94427862042872 0.00450900334755444 no 78 0.00161854219011121 70 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_679 0422-0091 41.4 µM 2.93797529153609 0.00458322343230072 no 79 0.00165181675921183 88 627384 YHR062C RPP1 SGTC_1374 2889-5571 141 µM 2.93560417066436 0.00461142380229329 no 80 0.0016644940764785 100 2853281 SGTC_790 1575-0012 79.1 µM 2.93306386313872 0.00464180808333648 no 81 0.0016781742264842 75 378741 YLR208W SEC13 SGTC_1844 rapamycin 4 nM 2.91937676083007 0.00480861232338315 no 82 0.0017536602161808 252 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_137 0438-0332 85.389 µM 2.9027942168564 0.0050178484578323 no 83 0.00184924786296738 197 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1040 k898-0338 155 µM 2.88852447068394 0.00520435273241187 no 84 0.00193526955750838 68 20969351 SGTC_1849 st056239 19.2 µM 2.88534628351063 0.00524672183908073 no 85 0.00195491671871034 83 5393181 SGTC_1826 st055655 41.6 µM 2.88102577347077 0.00530481153140154 no 86 0.00198191612985035 99 676168 SGTC_445 e6 berbamine 66 µM 2.85758130747406 0.00563010837354156 no 87 0.00213441626062709 208 6610268 A calcium/calmodulin antagonist. SGTC_2496 diffractaic acid 79.83 µM 2.85505888850007 0.00566614184060868 no 88 0.00215144248463019 76 94870 An apoptosis inducer which activates caspases. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.84988333570357 0.00574071775039403 no 89 0.0021867633947143 112 368090 SGTC_3317 9138495 8.753 µM 2.84089595409923 0.00587229108165859 no 90 0.00224934936037212 83 17020139 SGTC_3140 9094243 49.47 µM 2.83864986288156 0.00590558830468963 no 91 0.0022652419766085 80 19291112 SGTC_1627 st003713 25.6 µM 2.82463678199806 0.00611713213635083 no 92 0.00236671200381826 185 16195070 YER133W GLC7 SGTC_2249 haloperidol 116.36 µM 2.82189209026511 0.00615934409660251 no 93 0.00238706191735432 209 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2242 6630449 61.2675 µM 2.8214177424412 0.006166665418332 no 94 0.00239059487067842 94 691249 YDR170C SEC7 SGTC_142 0335-0849 62.6745 µM 2.80365154327875 0.006446488496996 no 95 0.00252637403776299 222 3889043 YPR107C YTH1 SGTC_2455 5377712 9.75 µM 2.77329076100631 0.0069507508614008 no 96 0.00277462569705932 77 2243908 SGTC_1016 4226-1401 38 µM 2.76415304854608 0.00710918828846945 no 97 0.00285353818727686 76 2901613 SGTC_1960 st011366 51.8 µM 2.74878174167979 0.00738290531153173 no 98 0.00299086011855778 47 3972846 SGTC_377 3970-0964 33.1 µM 2.72830970543307 0.00776185207049848 no 99 0.00318299041535858 141 16481235 SGTC_1726 st035556 14.5795 µM 2.72500469464933 0.00782460798038848 no 100 0.00321502863863158 129 5919439 SGTC_1657 st012939 43.4 µM 2.71783349895262 0.00796231256688251 no 101 0.00328554480027818 63 24207257 SGTC_3282 9108498 15.4605 µM 2.68902560527569 0.00853720000065984 no 102 0.00358304611161674 104 16459645 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.68838833690689 0.00855031872379265 no 103 0.00358989221644244 113 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1138 3761-0006 1.03 µM 2.68450793929783 0.00863058246336355 no 104 0.0036318329062103 43 12061087 SGTC_1557 sumaresinolic acid 42.3 µM 2.67367816503109 0.00885809596835346 no 105 0.00375122062767912 85 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_579 4491-1009 110 µM 2.67232419519224 0.00888690680159088 no 106 0.00376639169972042 105 1271041 SGTC_3093 9117344 49.47 µM 2.64679843491106 0.00944563949371687 no 107 0.00406288854241763 95 24824913 SGTC_2163 5671233 125 µM 2.62500636189955 0.00994671414488764 no 108 0.00433236741372334 118 701023 SGTC_253 dyclonine 31.25 µM 2.61716204581931 0.0101326798592021 no 109 0.00443321192087306 114 3180 An oral anasthetic. SGTC_1036 k216-0215 33.5 µM 2.61409986596226 0.0102060942122998 no 110 0.00447314413673984 152 622330 SGTC_171 k064-0041 9.68 µM 2.60224384868429 0.0104947298615995 no 111 0.00463079865369889 86 53325 SGTC_146 3448-8650 53.125 µM 2.59759316427172 0.0106098787264007 no 112 0.00469398247083655 265 2891488 YIL048W NEO1 SGTC_1402 3909-7673 35.9 µM 2.59496255196948 0.0106754975844993 no 113 0.0047300612795373 90 5328014 SGTC_158 k038-0087 26.446 µM 2.5907839355872 0.010780456999684 no 114 0.00478787957540023 253 X158 SGTC_2310 7668677 200 µM 2.58696882516334 0.0108770691934897 no 115 0.0048412175932038 129 2197143 SGTC_1722 st034304 3.6505 µM 2.58417595362591 0.0109482715514873 no 116 0.00488059911020216 136 4036148 YLR033W RSC58 SGTC_174 3553-0389 74.3 µM 2.57804356644408 0.0111060368527776 no 117 0.00496807348765831 101 738071 SGTC_2159 5658611 73.75 µM 2.57592363887256 0.0111610333202945 no 118 0.00499863610117829 61 793844 SGTC_2864 9034755 47.6 µM 2.56642318230297 0.0114104184021212 no 119 0.00513766910615345 91 4930451 SGTC_3233 9132340 49.47 µM 2.5628685711813 0.0115049631353625 no 120 0.00519056687248999 90 17682950 SGTC_2168 5727979 200 µM 2.55934794108171 0.0115992739802719 no 121 0.00524343612047076 88 695210 SGTC_1000 4048-0884 8.67 µM 2.52786328758817 0.0124729531361799 no 122 0.00573795143793564 118 13040088 SGTC_1182 1222-0449 220 µM 2.52499808447847 0.0125552188619147 no 123 0.00578494599662536 87 658318 SGTC_362 0310-0100 9.03 µM 2.52005183416994 0.0126983412307872 no 124 0.00586687769092488 139 790235 SGTC_1167 k781-0610 148 µM 2.51488477641645 0.0128493583846395 no 125 0.00595356459087769 122 4525169 SGTC_2023 5144124 124 µM 2.51313921838026 0.0129007254985063 no 126 0.00598310513083348 100 2830192 SGTC_1150 3909-7983 10.9 µM 2.50730461283374 0.0130737132752079 no 127 0.00608279099613301 124 23965914 SGTC_1478 0453-0656 35.7 µM 2.5049297393046 0.0131446969537903 no 128 0.00612378601309527 91 5258496 SGTC_1787 fluconazole 80 µM 2.50332508105663 0.0131928476483259 no 129 0.00615162398744361 162 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3223 9129970 49.47 µM 2.48378283609667 0.0137915871596248 no 130 0.0064997528233103 122 17248386 SGTC_878 0828-0289 13.7 µM 2.47840928436071 0.0139602762047799 no 131 0.00659848325381937 172 745350 YLR208W SEC13 SGTC_1001 4048-4355 44.4 µM 2.47099676791755 0.0141958907494568 no 132 0.0067368518243351 131 21824233 SGTC_1053 3366-3204 134 µM 2.47029165618481 0.0142184808731032 no 133 0.00675014667028654 131 3632071 YPR165W RHO1 SGTC_2377 9073351 62.6 µM 2.4656060426744 0.0143693849945353 no 134 0.00683908404794287 129 7337946 YHR072W ERG7 SGTC_1768 st044301 37.178 µM 2.46483503357531 0.0143943476660574 no 135 0.00685381727985983 121 3931349 SGTC_132 0417-1715 25.805 µM 2.46194012944016 0.0144884084613638 no 136 0.0069093866039344 107 6769098 SGTC_2152 5568786 200 µM 2.46168471553556 0.0144967326741564 no 137 0.00691430846469998 106 5399883 SGTC_951 1171-0579 82.7 µM 2.46062732130544 0.0145312380991059 no 138 0.00693471754911131 224 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2098 5376439 882.5 nM 2.45664489293847 0.0146618299231904 no 139 0.0070120617886534 102 2844116 SGTC_2810 7959871 45.46 µM 2.44930656396797 0.0149051142624159 no 140 0.00715657836220892 160 2974535 SGTC_724 3910-0327 137 µM 2.43639539516821 0.0153415819086472 no 141 0.00741722967021861 114 2885483 SGTC_2680 butyl paraben 22.24 µM 2.42934604323656 0.015584487837715 no 142 0.00756304378882799 87 7184 An antifungal and steroid mimetic. SGTC_1622 st003707 19.4 µM 2.4282102391098 0.0156239323967475 no 143 0.00758677227468749 180 10140899 SGTC_2291 7917025 104.35 µM 2.41650238685878 0.0160355435466796 no 144 0.00783521174687899 185 2964612 SGTC_641 4092-0595 30 µM 2.41404654125393 0.0161230527740973 no 145 0.00788822350476838 117 786260 SGTC_1347 1493-0251 600 nM 2.39751579266523 0.0167228072010381 no 146 0.00825333469728377 137 3986378 SGTC_2994 9053520 71.4286 µM 2.39408179349017 0.0168497628356174 no 147 0.00833101631650143 113 4647384 SGTC_2489 cantharidin 73.42 µM 2.38906097659505 0.0170368665645362 no 148 0.00844574929549761 194 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_315 k915-0449 187 µM 2.38843158069988 0.0170604461763553 no 149 0.00846022928432523 189 20970215 YNL149C PGA2 SGTC_114 0364-0001 490.298 µM 2.38737548215605 0.0171000743965788 no 150 0.00848457502286407 179 4003655 SGTC_1891 st059073 26.2 µM 2.38365240909522 0.0172404042066655 no 151 0.00857089236083367 133 688754 SGTC_187 1488-2104 32.728 µM 2.38079515473888 0.0173487658164367 no 152 0.0086376577226868 146 2852859 SGTC_3135 9127742 49.47 µM 2.37255058899449 0.0176647081019404 no 153 0.00883287188557438 100 3643468 SGTC_1615 st002656 86.5 µM 2.36793152242685 0.0178438532475027 no 154 0.00894392317518125 115 1584458 SGTC_1624 st003710 6.25 µM 2.36690835610552 0.0178837445486888 no 155 0.00896868691348313 171 24207033 SGTC_24 0417-1663 219 µM 2.35345944294735 0.0184152025513797 no 156 0.00929981837688129 114 4329390 SGTC_1368 1852-0141 284 µM 2.3516164768784 0.0184890683121361 no 157 0.00934601821198198 158 2838987 SGTC_2968 9090663 33.37 µM 2.35080534095015 0.0185216583733666 no 158 0.00936641547788755 156 25236811 SGTC_2415 st077333 57.7 µM 2.34367291538148 0.0188103389395796 no 159 0.00954745437520387 202 2766255 SGTC_2878 9043973 25.97 µM 2.3419247502115 0.0188816761907458 no 160 0.00959229124984274 103 6465167 SGTC_553 k007-0256 45.7 µM 2.33498079697103 0.0191673146679992 no 161 0.00977221196446147 150 6287000 SGTC_19 0279-0214 38.434 µM 2.32143961992896 0.0197349039433373 no 162 0.0101315646531639 232 3566274 YBR002C RER2 SGTC_1875 nocodazole 6 µM 2.31199095833863 0.0201393499114463 no 163 0.0103890907923558 151 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.30694058548447 0.0203583969012367 no 164 0.0105290662841449 132 4213774 SGTC_1939 st074455 53.6 µM 2.30386965011457 0.0204925755953129 no 165 0.0106149809252993 169 1644229 SGTC_1749 st037932 54.2 µM 2.29565237735487 0.0208553038346565 no 166 0.0108478827066114 151 594497 SGTC_1796 st049173 110.4 µM 2.28573278435463 0.0213004031695652 no 167 0.0111349480311244 91 94134 SGTC_200 k038-0079 37.545 µM 2.27558081643012 0.0217642206226897 no 168 0.0114355552938601 173 3436683 SGTC_1992 st073643 23.3 µM 2.27003432275623 0.0220212099453696 no 169 0.0116027503144095 114 3161292 SGTC_2688 kanamycin b 96.69 µM 2.26935826870117 0.0220527084476752 no 170 0.0116232738836419 707 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_493 zm226600 134 µM 2.26811383540369 0.0221107881382851 no 171 0.0116611346588031 157 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2709 st078560 56 µM 2.26810735156962 0.0221110910869385 no 172 0.0116613322037083 131 17250903 SGTC_1702 st027038 51 µM 2.26192867430232 0.0224013784249226 no 173 0.0118509052142805 151 5521182 SGTC_1389 3405-0187 19 µM 2.25828007325345 0.022574302137836 no 174 0.0119641019075671 148 799890 SGTC_1377 2944-0135 198 µM 2.25341419803772 0.0228066680402005 no 175 0.0121165225723515 188 1894137 SGTC_1856 st057054 55.7 µM 2.25161413103138 0.0228931379521504 no 176 0.0121733336397335 152 1266018 SGTC_3294 9122953 26.2835 µM 2.24140229639019 0.0233889285822169 no 177 0.0125000139534265 156 16459826 SGTC_2423 st077119 87.2 µM 2.23832060241059 0.0235403097706853 no 178 0.0126000777670014 154 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1489 4065-0444 182 µM 2.23679459894664 0.0236155757996662 no 179 0.0126498838601622 140 2877968 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.23671422069822 0.0236195458459542 no 180 0.0126525119832078 198 442882 SGTC_2805 7950783 58.44 µM 2.23565546991292 0.0236718921283514 no 181 0.0126871740291047 187 1178958 YDL195W SEC31 SGTC_2508 celastrol 40.54 µM 2.23522197553976 0.0236933528947149 no 182 0.0127013897317347 126 122724 Celastrol is a natural product and antioxidant. SGTC_1029 k015-0030 64.7 µM 2.23212966958205 0.0238469170723805 no 183 0.012803197007458 174 2208316 SGTC_1119 parthenolide 318.541 nM 2.22710125718473 0.0240984144823942 no 184 0.0129702536079009 232 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3008 9078912 71.4286 µM 2.22480205546457 0.0242141499153079 no 185 0.0130472646806335 147 16648731 SGTC_1111 tnp00062 510.699 nM 2.21473139262074 0.024726593929456 no 186 0.0133892533873863 137 676306 SGTC_555 4296-0685 37 µM 2.21098085811757 0.024919750087989 no 187 0.0135185813181813 149 2908540 YHR072W ERG7 SGTC_3014 9081533 49.47 µM 2.1826496171111 0.0264200939896036 no 188 0.01453081144093 132 21367265 SGTC_533 1222-0222 6.71 µM 2.17199813505059 0.0270033593179275 no 189 0.014927901792825 195 3982874 SGTC_2350 9023895 38.85 µM 2.16662893948545 0.0273014219371051 no 190 0.0151315794600075 191 2997209 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.15883064592239 0.0277392154277826 no 191 0.015431654003329 234 91467 include heat shock SGTC_981 1488-1094 54.9 µM 2.15705302822257 0.0278398247933027 no 192 0.0155007664498686 128 3449522 SGTC_2038 4100038 30.985 µM 2.15604566577155 0.0278969741864777 no 193 0.015540049763438 201 3596803 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.1556238463644 0.027920933733331 no 194 0.0155565244824262 150 2724278 An inhibitor of dopamine biosynthesis. SGTC_1192 1488-0095 21.4 µM 2.14697342361068 0.0284160742004593 no 195 0.0158976987319046 164 915875 SGTC_1827 berberine 7.24 µM 2.14638537544086 0.0284499969736901 no 196 0.0159211225685188 167 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2170 morpholine 200 µM 2.14158662272989 0.0287280842024796 no 197 0.0161133805736926 147 121171 Reacts with secondary amines. SGTC_3340 9146634 11.102 µM 2.14113217989035 0.0287545358753707 no 198 0.0161316901385843 172 4907387 SGTC_2934 9036370 36.88 µM 2.13675345057746 0.0290104468871084 no 199 0.0163090250304795 217 6462800 SGTC_812 4251-0442 148 µM 2.12226354066583 0.0298708263515876 no 200 0.0169078066706772 142 5723007 SGTC_1704 st028805 70.8 µM 2.12204909167065 0.0298837171114777 no 201 0.0169168078867172 146 2876101 SGTC_1623 st003709 20.3 µM 2.1197724838065 0.0300208511829791 no 202 0.017012618433703 288 16192618 SGTC_1277 0873-0036 22 µM 2.114869978925 0.0303179313830958 no 203 0.0172205152560547 225 5965735 SGTC_1966 st070145 16.1 µM 2.11169706931326 0.0305114977107471 no 204 0.0173562202813447 184 3748532 SGTC_18 0111-0177 500 nM 2.09774728405328 0.0313747001912856 no 205 0.0179637377618608 297 721752 SGTC_2266 7929956 200 µM 2.08462999885877 0.0322047135106647 no 206 0.0185514496266015 213 2967153 SGTC_638 3970-0837 4.09 µM 2.07737380783428 0.032671591347666 no 207 0.0188835358454468 220 4118451 YLR208W SEC13 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.0678096715323 0.0332954795888591 no 208 0.0193289619435698 288 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2657 nystatin 74.44 µM 2.06655521098591 0.0333780337527531 no 209 0.0193880424467372 196 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1889 st059080 5.18 µM 2.06254188458244 0.0336432775881376 no 210 0.0195780870895283 204 176925 Isolated from Daphnopsis sellowiana. SGTC_1244 0416-0015 52.5 µM 2.05977176770478 0.03382736673384 no 211 0.0197101823809453 223 96201 SGTC_1011 4112-3381 17.4 µM 2.05714727014479 0.0340025423910651 no 212 0.0198360309500094 228 2877139 SGTC_1959 st077091 55.8 µM 2.05033029333184 0.0344610385529305 no 213 0.020166105182356 243 821356 YKL052C ASK1 SGTC_1355 1499-0035 1.68 µM 2.04616828219511 0.0347434559427108 no 214 0.0203699083948042 212 1548538 SGTC_3335 9143315 29.6265 µM 2.03804387433799 0.0353002216579118 no 215 0.0207727726597056 188 4899691 SGTC_1818 st052136 56.3 µM 2.0339282240345 0.0355850476599734 no 216 0.0209794163946866 253 674169 SGTC_901 1112-0062 60.1 µM 2.02776146705578 0.0360153454679275 no 217 0.0212922994174664 164 1908457 SGTC_3077 9117319 49.47 µM 2.02610802393322 0.0361314394957971 no 218 0.0213768580122345 161 17154678 SGTC_410 α-linolenic acid 100 µM 2.00792466876873 0.0374284823149649 no 219 0.0223256486579211 217 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2425 5628681 7.85 µM 2.00282654202216 0.0377988877589825 no 220 0.0225979549553607 242 5714958 SGTC_750 4073-0104 132 µM 2.00282385730275 0.037799083603097 no 221 0.0225980990886616 169 22330957 SGTC_2244 6635614 200 µM 2.00266201292008 0.0378108913089494 no 222 0.0226067893856174 111 836499 SGTC_3137 9097352 49.47 µM 1.99811788081297 0.0381436489239361 no 223 0.0228519408183423 275 44120435 SGTC_727 3032-0951 202 µM 1.99647376954343 0.0382646307154275 no 224 0.0229411890629634 215 3652836 SGTC_1245 0418-0076 17.2 µM 1.9927601526932 0.0385390485964814 no 225 0.0231438585157414 233 6790114 SGTC_88 0180-0332 8.668 µM 1.99133552840115 0.0386447460103655 no 226 0.0232220059965903 222 3101745 SGTC_649 1123-0311 367 µM 1.97892630400231 0.0395754488681655 no 227 0.0239121521114938 300 693629 YIL048W NEO1 SGTC_1961 st076550 68.7 µM 1.9766377678445 0.0397490662017426 no 228 0.0240412949247014 194 1579337 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.97521193755013 0.0398575480246648 no 229 0.0241220508862651 231 16486 A toxic proline analog. SGTC_2105 5350118 200 µM 1.97419598070086 0.0399349920731076 no 230 0.0241797314279675 221 2133313 SGTC_2280 7785178 200 µM 1.97084983358455 0.0401909262589622 no 231 0.0243705273439827 194 2954328 SGTC_695 3505-6186 243 µM 1.95997766254523 0.0410317083607956 no 232 0.0249992005987483 217 1819379 SGTC_1258 0671-0043 57.1 µM 1.95752744099086 0.0412231485844952 no 233 0.0251427443860536 266 4298767 SGTC_1957 st077035 62.4 µM 1.9566706673959 0.0412902604765105 no 234 0.0251931003418382 193 705593 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.95453516669022 0.0414579218144098 no 235 0.0253189800859793 216 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.94989751791568 0.0418239306469077 no 236 0.0255941675216117 233 6312947 SGTC_927 2425-1185 123 µM 1.94678482408118 0.0420710524489847 no 237 0.0257802685614641 236 730375 SGTC_608 k048-0125 159 µM 1.94395242480819 0.0422969469440244 no 238 0.0259505942273531 233 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1259 0671-0132 43 µM 1.94300742328084 0.042372532321866 no 239 0.0260076307041112 253 X1259 SGTC_1002 4049-0206 172 µM 1.94003781161751 0.0426107663219302 no 240 0.0261875473953955 281 4662749 SGTC_605 1315-0399 119 µM 1.93903702796049 0.0426912967152849 no 241 0.0262484147821364 265 24020461 SGTC_59 0330-0160 1.33 µM 1.93439781204021 0.0430662105809278 no 242 0.0265321176355021 426 4293482 SGTC_1163 k060-0048 49.9 µM 1.93426743979482 0.043076784792325 no 243 0.0265401271800547 267 6809982 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.92544095219069 0.0437975739141017 no 244 0.0270871082178532 187 616764 SGTC_2273 7815444 169.05 µM 1.92369351468939 0.0439414206368839 no 245 0.027196505713897 234 2824616 SGTC_800 3448-7362 155 µM 1.91139941579425 0.0449642556534813 no 246 0.0279766358632218 532 15991913 SGTC_2540 epiandrosterone 100 µM 1.90424810273527 0.0455679868237294 no 247 0.0284389398279726 350 441302 A steroid. SGTC_2679 rapamycin 1 nM 1.90353482112643 0.0456285595633169 no 248 0.028485397261195 409 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_29 0299-0004 12.984 µM 1.89975877717518 0.045950304992835 no 249 0.0287323914757736 170 16871 A napthoquinone isolated from Swertia calycina. SGTC_1219 1469-0211 33.1 µM 1.89686398351305 0.0461981940176279 no 250 0.0289229460135397 214 6822282 SGTC_2014 4013930 200 µM 1.89683223593397 0.0462009185907086 no 251 0.0289250416589222 304 64556 SGTC_67 0335-0847 266 µM 1.8937889368838 0.0464626937527299 no 252 0.029126515343959 412 4552207 YOR254C SEC63 SGTC_2403 6032726 181.2 µM 1.8904751791974 0.046749085495792 no 253 0.0293472185548758 270 2881040 SGTC_755 1995-0008 37.3 µM 1.88576505510694 0.0471585935133601 no 254 0.0296633109568886 229 689533 SGTC_2477 5967686 25.23 µM 1.88245213274588 0.0474483447488394 no 255 0.0298873266265858 266 776118 SGTC_1438 4092-1045 4 µM 1.88219302557701 0.0474710665101183 no 256 0.0299049061377136 228 1351342 SGTC_2556 citropten 84.59 µM 1.87825074158783 0.0478178518121733 no 257 0.0301734358235991 294 2775 A potential DNA crosslinker. SGTC_313 3474-0040 5.03 µM 1.87714367434747 0.0479155995403179 no 258 0.0302492024465567 354 1043375 YIL048W NEO1 SGTC_2652 actinonin 100 µM 1.87661497673129 0.0479623369271439 no 259 0.0302854416010178 182 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_44 0929-0055 61.211 µM 1.86003788771496 0.0494463666424667 no 260 0.0314400828833259 251 1379590 SGTC_2940 9060638 45.86 µM 1.85503693551089 0.0499011932509804 no 261 0.0317954761666551 286 4027022 SGTC_2622 2-methoxyxanthone 59.94 µM 1.85156206859052 0.0502191856459783 no 262 0.0320443670623522 251 71034 A hepatoprotective. SGTC_1668 st014914 51.6 µM 1.85004571820546 0.0503584553249863 no 263 0.0321534802582095 232 2839556 SGTC_2753 fluvastatin 17.09 µM 1.84819436773111 0.0505289102908143 no 264 0.0322871149616331 299 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1090 efavirenz 20.7 µM 1.83689088226198 0.0515796210444564 no 265 0.0331130027872821 262 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 1.83514981303833 0.0517429944454654 no 266 0.0332417474530302 253 16667744 Haematoxylin. SGTC_1614 st002383 48.6 µM 1.8346825659683 0.0517869085527797 no 267 0.0332763684709764 262 1947235 SGTC_1051 3253-3903 78 µM 1.83336642086179 0.0519107653957544 no 268 0.0333740488866528 302 5509239 SGTC_3267 9137951 49.47 µM 1.83125296870136 0.0521101457785683 no 269 0.0335313969760787 180 16643986 SGTC_1524 corynanthine 62.1 µM 1.83006447337316 0.052222533846988 no 270 0.0336201492708578 263 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_690 glyoxal 20.3 µM 1.828967084158 0.0523264774708865 no 271 0.0337022696976356 351 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_823 0417-1665 178 µM 1.81563742377596 0.0536022085156975 no 272 0.0347130044579537 291 3429856 SGTC_1648 st011736 69.8 µM 1.81407679163844 0.0537531682833549 no 273 0.034832952033082 249 2855514 SGTC_1070 indatraline 8.81 µM 1.81178348886012 0.0539756098855094 no 274 0.0350098286553068 308 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1645 Cervolide 78 µM 1.80903822306648 0.0542428477636493 no 275 0.0352225326761499 239 23173 A fragrance. SGTC_352 k048-0007 5.11 µM 1.80823090140465 0.0543216353772021 no 276 0.0352852855400675 337 6811911 SGTC_838 0109-0203 71.4 µM 1.80683903447044 0.0544576821289114 no 277 0.0353936902527223 255 759422 SGTC_3104 9120930 49.47 µM 1.8000681704936 0.055123342178636 no 278 0.0359249373718642 237 17014836 SGTC_985 1493-0307 8.71 µM 1.7998455759624 0.0551453346372517 no 279 0.0359425126096848 222 3278274 SGTC_765 1319-0117 244 µM 1.79188390860515 0.0559365190586282 no 280 0.0365757820459723 265 3487746 YGL099W LSG1 SGTC_2817 7995342 71.43 µM 1.78802899163109 0.0563228023499494 no 281 0.0368856652710878 250 18879975 SGTC_256 clotrimazole 625 nM 1.78645910191373 0.0564807149800981 no 282 0.0370124767674122 300 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1591 genipin 88.4 µM 1.7860858833455 0.0565183077094704 no 283 0.0370426767392662 240 442424 A DNA cross-linking agent. SGTC_2228 7354201 200 µM 1.78290744888193 0.0568392574673395 no 284 0.0373006851690861 221 753451 SGTC_2251 lansoprazole 556 µM 1.78086851100636 0.0570458985053149 no 285 0.0374669669390918 226 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1474 0330-0125 5.35 µM 1.77990086622938 0.0571441735048024 no 286 0.0375460929602262 280 X1474 SGTC_1491 4138-0063 26.5 µM 1.77817147622554 0.0573201439949922 no 287 0.0376878480592191 237 23883227 SGTC_2972 9093619 59.92 µM 1.77807287926712 0.0573301893575742 no 288 0.0376959430272809 292 25236256 SGTC_216 k038-0035 28.382 µM 1.77525969964671 0.0576173888123285 no 289 0.0379275081834364 262 4444231 YPR107C YTH1 SGTC_3171 9103192 49.47 µM 1.77464099877444 0.0576807039493732 no 290 0.0379785915554008 221 13018434 SGTC_1514 1189-1591 158 µM 1.76962373990672 0.0581961710664844 no 291 0.0383949207022831 363 767698 YMR146C TIF34 SGTC_2268 7933382 153.85 µM 1.76761521202321 0.0584035364087921 no 292 0.0385626265830784 368 935025 YOR257W CDC31 SGTC_50 0929-0078 56.389 µM 1.75893361093709 0.0593065281031212 no 293 0.0392943927456015 314 1377751 SGTC_558 k064-0027 21.3 µM 1.75881382218744 0.0593190637168189 no 294 0.0393045681437897 307 5088526 SGTC_665 3914-0008 307 µM 1.7532000101267 0.0599088694838287 no 295 0.0397838406477431 303 1069549 SGTC_467 ro 31-8220 72.8 µM 1.75148285091851 0.0600901943770069 no 296 0.0399313863624337 366 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2701 st077767 14.721 µM 1.74963613623494 0.0602856790585769 no 297 0.0400905600503024 359 5721188 SGTC_3013 9080133 71.4286 µM 1.74719343298994 0.060545016567418 no 298 0.04030189523814 346 17050193 SGTC_3156 9099931 49.47 µM 1.74215334396668 0.0610828716315904 no 299 0.0407408077212672 283 18111053 SGTC_2484 5809818 12.04 µM 1.73949505486126 0.0613680524209518 no 300 0.0409738606569185 297 2870548 SGTC_95 0471-0001 561.058 µM 1.73739912730301 0.0615936356467076 no 301 0.0411583725966957 320 4015405 SGTC_2245 6637752 200 µM 1.73656981109827 0.0616830729670324 no 302 0.0412315660157294 233 681890 SGTC_77 0828-0286 12.516 µM 1.73384160386695 0.0619780111132202 no 303 0.0414730957641674 342 745345 SGTC_1326 1431-2094 10.8 µM 1.73225468026302 0.0621500741299461 no 304 0.0416141135927677 350 616278 SGTC_1271 0832-2808 169 µM 1.731411515498 0.0622416461829981 no 305 0.0416891971039315 311 3663794 SGTC_268 camptothecin 39.6153 µM 1.72270859079755 0.0631929885143302 no 306 0.0424706180054277 440 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_54 0159-0055 9 µM 1.71676310869953 0.0638493899327663 no 307 0.0430112320171346 317 3319099 SGTC_2173 5763948 167 µM 1.71057083803613 0.064538662795454 no 308 0.043580183088142 325 2867177 SGTC_3006 9075424 71.4286 µM 1.71052118454077 0.0645442130843197 no 309 0.0435847697221647 313 7465181 SGTC_2678 equilin 100 µM 1.70825718657719 0.064797677844606 no 310 0.0437943158138624 332 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3197 9113331 49.47 µM 1.70807181649162 0.0648184650424522 no 311 0.0438115088216424 347 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1529 apigenin 74 µM 1.70749392541446 0.0648833023457731 no 312 0.0438651429575554 365 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1944 st076371 56.9 µM 1.7064590454101 0.0649995379721255 no 313 0.043961322622525 324 24208455 SGTC_1390 3413-2614 145 µM 1.70609538795543 0.0650404215962021 no 314 0.0439951605698015 337 3421432 SGTC_1442 4112-3290 3 µM 1.70579650632899 0.0650740378386083 no 315 0.044022986916182 333 704353 SGTC_1646 st011709 75.6 µM 1.69929153705261 0.0658090192972344 no 316 0.0446321331799614 260 5757843 SGTC_1548 st061468 90.8 µM 1.69897293933045 0.0658451815283616 no 317 0.0446621412258282 295 390799 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.69808802176408 0.0659457043286726 no 318 0.0447455749944488 364 6708561 SGTC_293 4049-0273 38.5 µM 1.69606904376649 0.0661754966227845 no 319 0.0449364026575873 282 1380311 SGTC_380 3970-0968 6 µM 1.69530590980303 0.0662625149356136 no 320 0.0450087021489004 315 2891601 SGTC_3092 9117248 49.47 µM 1.69479751182926 0.0663205354886384 no 321 0.0450569198352085 253 17141857 SGTC_1139 k015-0024 46.9 µM 1.68756933489253 0.0671497081398275 no 322 0.0457469649375326 278 2766652 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.68600098464774 0.0673306736811808 no 323 0.0458978048534062 321 5282362 SGTC_1287 0971-0001 34.6 µM 1.68414151237606 0.0675457187984955 no 324 0.0460771616640094 380 4665869 SGTC_2144 5628481 200 µM 1.68120544665799 0.0678863503881121 no 325 0.0463615079687746 300 2818399 SGTC_2197 6588183 93.1375 µM 1.67920775024114 0.068118873134066 no 326 0.0465557810233644 259 884136 SGTC_1809 st050081 57.6 µM 1.67584908869245 0.0685111911168188 no 327 0.0468838780394506 320 5036894 SGTC_1862 st057513 3.81 µM 1.66938145223987 0.0692715687718533 no 328 0.0475209035421996 318 5393163 SGTC_1798 st045719 60.953 µM 1.66853848551248 0.0693711504994902 no 329 0.0476044393452284 274 3980186 SGTC_1300 1094-0077 113 µM 1.66648185873437 0.0696145675216161 no 330 0.0478087392686144 299 5532636 SGTC_2093 5331342 194.4 µM 1.66314530959537 0.0700108709777301 no 331 0.0481416760124556 341 33839 SGTC_2317 5986382 200 µM 1.65829079628938 0.0705905698507025 no 332 0.048629392903932 317 877883 SGTC_2801 7907800 81.82 µM 1.65821832605896 0.0705992517049649 no 333 0.0486367035615785 353 6620925 SGTC_1062 mesoridazine 14.2 µM 1.65515696681266 0.0709667492655702 no 334 0.0489463309072383 356 4078 A neuroleptic. SGTC_2050 5263056 171 µM 1.65407400052219 0.0710971040284323 no 335 0.0490562389974241 411 763468 YGL055W OLE1 SGTC_488 nitrendipine 139 µM 1.64753109204976 0.071888577043271 no 336 0.0497244654298063 355 4507 Dihydropyridine L-type calcium channel blocker. SGTC_921 1561-0023 372 µM 1.64600443114028 0.0720742205055392 no 337 0.0498814233617548 363 24050882 SGTC_464 bw-b 70c 158 µM 1.64207779832579 0.0725533910664021 no 338 0.0502869410586303 396 5353454 SGTC_3132 9126706 49.47 µM 1.63751409198834 0.0731133660455703 no 339 0.0507615484545017 333 850858 SGTC_1636 st007707 68.9 µM 1.63677954346045 0.0732038046424464 no 340 0.0508382707780257 399 403051 SGTC_1725 st036284 20.55 µM 1.6356746721086 0.0733399990414028 no 341 0.050953846528297 408 707914 SGTC_2885 9057732 51.95 µM 1.63279615042802 0.0736957365820985 no 342 0.0512559384929912 341 6471414 SGTC_107 0358-0022 2.6945 µM 1.63233090346753 0.0737533570087509 no 343 0.0513048982174101 219 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.63174252300204 0.0738262767166595 no 344 0.0513668690209151 338 641818 YHR062C RPP1 SGTC_2043 5101342 149 µM 1.63021663206957 0.0740156415646902 no 345 0.0515278599742831 369 678451 SGTC_2476 5806916 10.51 µM 1.62593045812715 0.0745495460182185 no 346 0.0519822249358658 325 2870194 SGTC_708 3448-5400 146 µM 1.62588719044348 0.0745549505767557 no 347 0.0519868277953409 391 3462195 SGTC_803 4488-1585 147 µM 1.62376637773316 0.0748202276661055 no 348 0.0522128391823827 320 747204 SGTC_1420 4'-methoxyflavone 42 µM 1.61853538680582 0.0754776125544987 no 349 0.0527736335210144 325 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2086 5274770 176.623 µM 1.61756464767093 0.0756000892521332 no 350 0.0528782264948101 356 689278 SGTC_1123 mangostin 811.285 nM 1.61539786873724 0.0758740146307207 no 351 0.0531122807468228 402 5281650 An antioxidant. SGTC_3227 9130768 49.47 µM 1.61149334491014 0.0763695339576801 no 352 0.0535361182936978 309 17720899 SGTC_3255 9139072 49.47 µM 1.60275883904326 0.0774869322306427 no 353 0.0544939537562668 356 17646060 SGTC_839 0122-0028 230 µM 1.60105634718451 0.0777061692751328 no 354 0.0546822197726729 439 759448 SGTC_1415 3966-0071 78.1 µM 1.60089848514836 0.0777265216652274 no 355 0.0546997025909778 354 2893185 SGTC_1955 wogonin 32.4 µM 1.59971074814707 0.0778797806355751 no 356 0.0548313831815135 352 5281703 A flavanone. SGTC_1790 st045711 43.5 µM 1.59897291575102 0.0779751018344441 no 357 0.0549133103814772 365 585119 SGTC_2028 5153890 36.43 µM 1.59694130973963 0.0782380241960473 no 358 0.055139395184778 373 2830968 YPR165W RHO1 SGTC_1190 1486-1332 13 µM 1.59602782612256 0.0783564625064095 no 359 0.0552412904500035 361 4150046 SGTC_288 1315-0019 35.1 µM 1.59555865986984 0.0784173453801814 no 360 0.0552936817545 378 6811474 SGTC_572 0960-0087 17.7 µM 1.59162764479145 0.0789288762215542 no 361 0.0557341973512434 440 6796365 SGTC_2853 9015042 58.44 µM 1.59087845905023 0.0790266515724349 no 362 0.055818465613074 337 6457456 SGTC_497 capsazepine 133 µM 1.58617472910589 0.0796426269542545 no 363 0.0563498393338492 344 2733484 A calcium channel blocker. SGTC_828 2074-0507 139 µM 1.58234602688125 0.0801466895082008 no 364 0.0567852994003716 406 X828 SGTC_1994 st072947 40.9 µM 1.5822399643641 0.080160687271834 no 365 0.0567974001161992 377 5286565 YDL195W SEC31 SGTC_505 gw-5074 63.9 µM 1.58220957823339 0.0801646978686417 no 366 0.0568008672564926 400 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2563 tomatine 8.54 µM 1.58067345356376 0.0803676452006446 no 367 0.0569763605898821 463 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1093 fluphenazine 7.97 µM 1.5766185786621 0.0809052256094638 no 368 0.0574416576230275 430 6602611 An atypical antipsychotic. SGTC_1682 st012968 530 nM 1.57330157351939 0.0813469968984877 no 369 0.057824502587308 349 24207270 SGTC_587 k089-0003 57 µM 1.57106707259472 0.0816456203484987 no 370 0.058083534995581 236 9659696 SGTC_651 3253-0966 34.4 µM 1.5658357063233 0.0823479828101917 no 371 0.0586935423487273 419 781462 SGTC_2202 7226349 200 µM 1.5655366520803 0.0823882708441366 no 372 0.0587285651683413 308 844334 SGTC_2732 terfenadine 20 µM 1.56539697380074 0.0824070931273543 no 373 0.0587449287800553 309 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1014 4130-3005 69.3 µM 1.56093605618662 0.0830099263140602 no 374 0.0592694194576587 422 743608 SGTC_447 ml7 120 µM 1.56051470115596 0.0830670377953497 no 375 0.0593191493100796 386 4216 Selective myosin light chain kinase inhibitor. SGTC_963 1269-2853 151 µM 1.55997267291646 0.083140549067554 no 376 0.0593831695578903 383 3668223 SGTC_2457 5731572 11.68 µM 1.55437533171612 0.0839025381512245 no 377 0.0600474569453834 347 2865357 SGTC_495 decylubiquinone 155 µM 1.55306266109715 0.0840819942494214 no 378 0.0602040826935238 390 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.55157874770717 0.0842852078926829 no 379 0.0603815257716645 425 5106787 A p450 inhibitor. SGTC_1196 1588-0294 184 µM 1.55088780321031 0.0843799545526296 no 380 0.060464286913932 361 6144269 SGTC_1109 tnp00067 928.257 nM 1.55039963890013 0.0844469428794485 no 381 0.0605228125894845 366 676295 SGTC_1082 camptothecin 424.86 nM 1.54081468363063 0.085770333384982 no 382 0.0616809473486604 380 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2549 cedrol 20.94 µM 1.54078371261262 0.0857746345583754 no 383 0.0616847173759744 337 6708665 A sedative which affects the nervous system. SGTC_2453 5731132 22.18 µM 1.53892909842592 0.0860324929046124 no 384 0.0619108032173609 416 1362040 SGTC_1766 st045414 44.774 µM 1.53792832100921 0.0861718778170365 no 385 0.062033070864407 440 253960 SGTC_658 3253-0951 102 µM 1.53482630491192 0.0866049894333917 no 386 0.0624132497606073 525 1184878 SGTC_1199 1638-0010 4.46 µM 1.53472417364337 0.0866192768864513 no 387 0.0624257976551029 444 3111136 SGTC_2568 diosmetin 100 µM 1.52904922062208 0.0874159347001985 no 388 0.0631261211834136 427 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3051 9093778 49.47 µM 1.52810539806509 0.0875489585590664 no 389 0.0632431857226677 305 17217378 SGTC_2665 lovastatin 100 µM 1.52328406256275 0.0882308428119366 no 390 0.0638438263462369 387 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2446 5162541 200 µM 1.52122429907703 0.0885233601908667 no 391 0.0641017798231392 391 1549321 SGTC_413 propylparaben 100 µM 1.52118249330354 0.0885293047108497 no 392 0.0641070237259493 365 7175 A pharmaceutical preservative. SGTC_3327 9140648 26.9345 µM 1.52084687487699 0.0885770383329184 no 393 0.0641491340744341 382 8029710 SGTC_2026 5148700 152 µM 1.51576273609576 0.0893024810570133 no 394 0.0647896788723372 405 79838 SGTC_1148 3909-7663 27.7 µM 1.51084690122027 0.090008103156153 no 395 0.0654137310042507 421 4084526 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.50455301066591 0.0909175692378971 no 396 0.066219517390737 472 5024745 SGTC_1128 3448-9350 235 µM 1.49947715538244 0.0916559816549586 no 397 0.0668749454048159 393 619386 SGTC_3148 9097893 49.47 µM 1.4980793506561 0.0918601061538817 no 398 0.0670563176775916 415 17174100 SGTC_2664 lyso-paf C-16 73.48 µM 1.4978753900988 0.0918899190907089 no 399 0.0670828143722799 437 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2009 4012297 12.05 µM 1.49169900298573 0.0927961196684539 no 400 0.067889035306862 423 45595307 SGTC_3167 9103034 49.47 µM 1.49135555787205 0.0928467032606936 no 401 0.0679340848107748 329 5127859 SGTC_3232 9132874 49.47 µM 1.48810488309959 0.0933264821143447 no 402 0.0683616179546013 394 3784940 SGTC_2837 9008476 45.46 µM 1.48583009340693 0.0936633142622084 no 403 0.0686620340374831 459 2992805 SGTC_1357 1503-1303 39.5 µM 1.48570894505635 0.0936812780556505 no 404 0.0686780617902541 485 292895 SGTC_3023 9089636 49.47 µM 1.48459489955129 0.0938465872120886 no 405 0.068825583696399 419 17249241 SGTC_2845 9003024 42.97 µM 1.48028682926792 0.0944878724034333 no 406 0.069398358305776 456 2990173 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.47978357380135 0.0945629956079766 no 407 0.0694655068543112 473 165506 SGTC_2760 etidronate 98.04 µM 1.47827259925602 0.0947888101092805 no 408 0.0696674143509888 442 3305 A chelator and antioxidant. SGTC_2771 fluoxetine 41.05 µM 1.47536476742408 0.0952245021013209 no 409 0.0700572511465679 399 3386 A selective serotonin reuptake inhibitor. SGTC_3272 9137413 49.47 µM 1.47401609528521 0.095427078855688 no 410 0.0702386288122563 416 17614870 SGTC_1519 esterone 74 µM 1.47209190300706 0.095716650276426 no 411 0.0704980308605116 457 698 A steroid. SGTC_887 0885-0007 9.62 µM 1.4691398719287 0.0961621568991313 no 412 0.0708974275204728 467 5719458 SGTC_3192 9110362 49.47 µM 1.46803956086138 0.0963286000485593 no 413 0.0710467385915289 442 16649480 SGTC_2731 amoxapine 43.43 µM 1.46487082551247 0.0968091147326284 no 414 0.0714780819270076 264 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_999 SEC7.066 22.7 µM 1.45927859149011 0.097661424700398 no 415 0.0722442226429375 485 740511 YDR170C SEC7 SGTC_3060 1327-0027 12.5 µM 1.45735752450328 0.0979554796626544 no 416 0.0725088577423911 406 16000455 YPR107C YTH1 SGTC_1203 3992-3522 103 µM 1.45699197853502 0.0980115066617836 no 417 0.0725592972315957 488 5322312 SGTC_1191 1487-1166 10.6 µM 1.45656020089642 0.0980777151923125 no 418 0.0726189102463142 521 3955771 SGTC_3336 9143619 71.43 µM 1.45633592558603 0.0981121183657818 no 419 0.0726498894258233 465 45595730 SGTC_3337 9144342 33.5465 µM 1.45344061554636 0.0985570444851565 no 420 0.0730507282437024 436 17682949 SGTC_1700 st030840 7.9285 µM 1.45280491966298 0.098654930164069 no 421 0.0731389628170988 471 5499307 SGTC_2723 salbutamol 83.58 µM 1.45166325756133 0.0988309041201536 no 422 0.0732976301979042 337 9884233 β2-adrenoceptor agonist SGTC_1311 1190-0148 100 µM 1.45158709199341 0.0988426523255378 no 423 0.073308224996043 549 1961333 SGTC_1401 3807-4679 7.6 µM 1.45098566818508 0.0989354552080357 no 424 0.0733919255221323 403 3291456 SGTC_3123 9126162 49.47 µM 1.44679682208961 0.099583585004991 no 425 0.073976918550873 437 25239884 SGTC_1426 4048-4480 71.7 µM 1.44526575689323 0.0998212555787072 no 426 0.0741916261948253 468 14224343 SGTC_1452 4194-0072 190 µM 1.44504950750102 0.0998548578074221 no 427 0.074221990067814 492 1343545 SGTC_1914 st062367 72.6 µM 1.44453252740756 0.0999352230010962 no 428 0.0742946184152861 435 978205 SGTC_744 1594-0068 283 µM 1.44294481106664 0.100182330749135 no 429 0.0745180092607113 501 668392 SGTC_2956 9076196 2.52 µM 1.44127671374592 0.100442428943592 no 430 0.0747532616167414 458 16423868 SGTC_479 n-linoleoylglycine 10 µM 1.43844687436747 0.100884798225013 no 431 0.0751536504124039 404 6433346 An anti-infammatory. SGTC_847 0342-0274 5.54 µM 1.43841673401449 0.10088951749181 no 432 0.0751579236995046 459 18097 SGTC_2299 7976368 114.88 µM 1.4375758217523 0.101021249370953 no 433 0.0752772226079744 438 2979718 SGTC_2566 crystal violet carbinol 226 nM 1.43664748692597 0.101166821862035 no 434 0.0754090916103359 418 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3016 9080866 49.47 µM 1.4363071030278 0.101220235857087 no 435 0.0754574868790616 478 17066299 SGTC_1707 st032323 6.317 µM 1.43586952020995 0.101288932764936 no 436 0.0755197365121851 487 3132057 YMR211W DML1 SGTC_287 k060-0039 29.6 µM 1.43503248442797 0.101420435132627 no 437 0.075638920513393 433 5861974 SGTC_1320 1313-0481 95.3 µM 1.43177786037095 0.101932934174055 no 438 0.076103702657747 455 6813365 YLR208W SEC13 SGTC_1461 k072-0203 53.8 µM 1.43172635991282 0.101941058966827 no 439 0.0761110747025553 434 5418714 SGTC_1294 1000-1494 117 µM 1.4285208939171 0.102447686266828 no 440 0.0765709925474283 447 712797 YDL207W GLE1 SGTC_233 rapamycin 362 pM 1.42587699649828 0.102866932835892 no 441 0.076951925261747 450 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1575 cyproterone acetate 48 µM 1.42483317309815 0.103032796165151 no 442 0.077102715323804 466 9880 An androgen receptor antagonist and liver toxin. SGTC_1183 1254-0324 198 µM 1.4183050317243 0.104074524466272 no 443 0.0780508641465933 470 5799357 SGTC_1795 st049545 62.3 µM 1.41765068418759 0.104179361570286 no 444 0.0781463873794621 449 5291882 SGTC_231 b-estradiol 524 µM 1.41387560956536 0.104785684905216 no 445 0.0786992142327515 400 450 A steroid. SGTC_2713 st079149 53.4 µM 1.41255085014059 0.104999062066441 no 446 0.0788939146156386 500 3103253 SGTC_1609 st001574 46.4 µM 1.41242252438686 0.105019748014427 no 447 0.0789127940675204 476 3960012 SGTC_2544 sphondin 68.51 µM 1.40980843161515 0.105441778720715 no 448 0.0792981281430917 434 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_220 paclitaxel 373.376 µM 1.4050303857984 0.106216335167016 no 449 0.0800061214362713 400 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2776 terbinafine 19.92 µM 1.40334526989513 0.106490482800151 no 450 0.0802569524548309 475 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_403 arphamenine a 50 µM 1.40237106703931 0.106649206472861 no 451 0.0804022342886573 502 5487158 An arginine aminopeptidase inhibitor. SGTC_689 0833-0039 98 µM 1.40149607559372 0.106791911449176 no 452 0.0805328901348885 487 5374726 SGTC_43 0570-0105 72.5 µM 1.3999301928699 0.107047639791336 no 453 0.0807671117891917 591 1114046 YDL195W SEC31 SGTC_2833 9001315 45.46 µM 1.39920640173039 0.107165993133844 no 454 0.0808755487120463 505 2989378 SGTC_367 0335-0881 7.1 µM 1.39877667636531 0.107236305867581 no 455 0.080939981274261 521 23828853 SGTC_1937 st074714 47.2 µM 1.39666751874193 0.107581893782855 no 456 0.0812567880439534 490 17250970 SGTC_14 0354-0009 295 µM 1.39665189910252 0.107584456068951 no 457 0.0812591376821433 499 1713507 SGTC_1732 st034308 51.822 µM 1.39268053198014 0.108237357082359 no 458 0.0818582091118135 473 830119 SGTC_2951 9072950 58.06 µM 1.3891569785591 0.108819020024948 no 459 0.0823925103051558 507 16488155 SGTC_168 3970-0862 530.542 µM 1.38839859933584 0.108944505516752 no 460 0.0825078513296567 682 3135186 SGTC_957 1187-1561 14.1 µM 1.38720605311631 0.109142040945337 no 461 0.082689470105831 512 1538454 SGTC_2065 5221596 34.26 µM 1.38663739398856 0.109236325204866 no 462 0.0827761798899523 489 788581 SGTC_1822 st052468 42 µM 1.38599214032228 0.109343379773853 no 463 0.0828746517366021 450 2873678 SGTC_1396 3511-0007 98.6 µM 1.38208992711047 0.109992405471201 no 464 0.0834720454709677 426 X1396 SGTC_1922 5578187 25 µM 1.3818556182041 0.110031464089383 no 465 0.0835080187874273 480 1350412 SGTC_2575 plumbagin 510 nM 1.37904236235607 0.110501202900509 no 466 0.083940846525128 490 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3198 9112019 49.47 µM 1.37823449745805 0.110636360130524 no 467 0.0840654497353439 474 45595555 SGTC_2804 7954240 19.48 µM 1.37754491717825 0.110751821830938 no 468 0.0841719188121328 527 828705 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.37662284031764 0.110906347094233 no 469 0.0843144427651596 436 279621 SGTC_1485 3909-9022 254 µM 1.37224416516341 0.111642250844814 no 470 0.0849937203999327 512 714516 SGTC_3212 9128307 49.47 µM 1.3713533754342 0.111792388430359 no 471 0.0851324121670841 446 27243542 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.36947879414321 0.112108810124709 no 472 0.0854248295205895 384 279621 SGTC_1767 st044992 70.3 µM 1.36785850651502 0.112382823490621 no 473 0.0856781850066728 510 9600693 SGTC_2904 7225135 42.03 µM 1.36647546012056 0.112617094315695 no 474 0.085894889064361 511 4446116 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.36289856038301 0.113224593463668 no 475 0.0864572412495444 546 5379071 SGTC_1310 1188-0297 994 nM 1.35959473284872 0.113787787912123 no 476 0.0869791029298393 515 1588352 SGTC_2706 st078239 82.5 µM 1.3515162762885 0.115173302526173 no 477 0.088265054821392 499 15434492 SGTC_3061 glucosamine 200 µM 1.34918318377471 0.115575668014611 no 478 0.0886390673824347 481 91431 and experimental redox chemotherapeutic SGTC_2966 9084041 48.03 µM 1.33432456711792 0.118161627444528 no 479 0.091048754809575 511 17741380 SGTC_2534 helenine 20.12 µM 1.33365782472586 0.118278617386181 no 480 0.0911580113805448 455 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1264 0783-0040 158 µM 1.33350597441381 0.118305273244207 no 481 0.0911829081081308 485 2855798 SGTC_1417 3966-0327 90.4 µM 1.33112245895686 0.118724233020403 no 482 0.0915743600773346 572 651118 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.31934749638126 0.120809341533104 no 483 0.0935264829327299 506 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2766 oltipraz 83.91 µM 1.31787150062645 0.121072517380966 no 484 0.093773333745703 524 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2409 alverine citrate 63.97 µM 1.31742311751116 0.121152545665935 no 485 0.0938484181065297 545 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2079 5212404 121 µM 1.3166719112362 0.121286705787338 no 486 0.0939743114021016 515 758462 SGTC_2261 9010538 184.68 µM 1.3159593866818 0.12141405413794 no 487 0.0940938372217827 452 6457250 SGTC_1345 1488-0192 31.4 µM 1.31468828804473 0.121641468901659 no 488 0.0943073421662356 543 658348 SGTC_3115 9123671 49.47 µM 1.30542647381135 0.123307557171189 no 489 0.0958738342957466 533 3286988 SGTC_2136 5328288 199.296 µM 1.30495530565914 0.123392739939526 no 490 0.0959540336036613 457 262395 SGTC_2618 avocadyne 43.43 µM 1.29891067040178 0.124489211026622 no 491 0.0969872936698127 513 3015189 SGTC_896 0964-0007 44.5 µM 1.29803171918724 0.12464921457646 no 492 0.0971382177850012 551 6756758 SGTC_854 0422-0053 192 µM 1.29342821667325 0.125489580124715 no 493 0.0979314981430662 536 3596728 SGTC_2733 amorolfine 100 µM 1.29285797802179 0.125593951297047 no 494 0.098030091797293 425 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2256 7954252 200 µM 1.29224349826628 0.125706487734954 no 495 0.0981364160864781 459 2972920 SGTC_1273 0849-0096 14.1 µM 1.29124205984177 0.125890042879493 no 496 0.0983098773762977 541 5286025 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.29035434400289 0.126052909856671 no 497 0.0984638281931252 515 6708514 SGTC_475 α-linolenic acid 10 µM 1.2901559457427 0.126089329558698 no 498 0.0984982592414213 573 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2581 avocatin a 64 µM 1.28981228792364 0.126152431719785 no 499 0.0985579202335991 596 6710728 A skin care supplement. SGTC_1416 3966-0321 25.3 µM 1.2889431153118 0.126312126700902 no 500 0.0987089317040528 575 582530 YLR208W SEC13 SGTC_3127 9126946 49.47 µM 1.28766103874853 0.12654794249266 no 501 0.0989319908017806 488 27243249 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.28653650265555 0.126755033751122 no 502 0.0991279439804633 532 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2794 7785382 27.27 µM 1.28561584780303 0.126924754429601 no 503 0.0992885815551702 669 2205081 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.28475158657894 0.127084222957529 no 504 0.0994395525844626 547 6710655 SGTC_2360 9040895 200 µM 1.28437720899449 0.127153344224625 no 505 0.0995050017339077 518 4914414 SGTC_2044 5102272 200 µM 1.28243100709375 0.127513092572824 no 506 0.0998457464370249 505 592666 SGTC_3254 9136651 49.47 µM 1.2801280788069 0.127939693941826 no 507 0.100250047471499 585 16454030 SGTC_285 1486-1325 46 µM 1.28000560945365 0.127962408270385 no 508 0.100271581549973 591 22310230 SGTC_2826 7992541 19.48 µM 1.27739207878888 0.12844780643996 no 509 0.100731929958147 541 2985066 SGTC_1455 4262-0120 131 µM 1.2765097260587 0.128611969687242 no 510 0.10088769544403 585 1529587 SGTC_2921 7974240 10.71 µM 1.27569929402819 0.128762880193671 no 511 0.101030919123487 565 2979074 YDR527W RBA50 SGTC_2051 5263410 176 µM 1.27379388361093 0.12911817038162 no 512 0.101368236694883 583 227584 SGTC_1880 MG-132 525 µM 1.27305183951634 0.129256718508656 no 513 0.101499823566865 519 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2513 baicalein 25.65 µM 1.27292758834555 0.129279927692726 no 514 0.101521869213461 564 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2380 9035439 200 µM 1.27113854051165 0.129614428606371 no 515 0.101839683215262 619 6462575 SGTC_602 3130-1533 38.1 µM 1.26831417861716 0.13014372314138 no 516 0.102342887840101 614 720941 SGTC_2441 5730946 39.09 µM 1.2681273820433 0.130178782080034 no 517 0.102376232234634 578 1774275 SGTC_1990 st072050 59.8 µM 1.26758834356959 0.130279988221883 no 518 0.102472498374128 580 17233948 SGTC_610 4215-0184 155 µM 1.26573970455968 0.130627489321623 no 519 0.102803144155334 601 5605015 SGTC_720 r052-1644 49.9 µM 1.26550597840272 0.130671469990398 no 520 0.102845003331678 503 1422863 YOR257W CDC31 SGTC_392 N-ethylmaleimide 8.33 µM 1.26329107704731 0.131088760133949 no 521 0.103242295884194 542 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3169 9102970 49.47 µM 1.26156556721535 0.131414485601033 no 522 0.103552576390299 558 17027839 SGTC_731 3966-0296 387 µM 1.26012205267025 0.131687407584111 no 523 0.103812668031948 569 660956 SGTC_781 4335-2806 94.4 µM 1.25819214580751 0.132052901293242 no 524 0.104161137382811 658 845254 SGTC_1253 0550-0034 176 µM 1.25735774098737 0.13221114071916 no 525 0.104312062116475 535 5969915 SGTC_819 1013-0258 27.7 µM 1.25522003977839 0.132617138079747 no 526 0.104699446336878 572 5753198 SGTC_1325 1431-0015 227 µM 1.25181076284655 0.133266411736983 no 527 0.10531941368799 561 1103340 SGTC_2785 7756463 72.73 µM 1.24737666748269 0.134114122496945 no 528 0.106129708865238 563 2201551 SGTC_368 fentichlor 4.58 µM 1.2463583170735 0.134309332759199 no 529 0.106316438463229 490 7329 A pesticide. SGTC_943 3253-1379 105 µM 1.24480362760794 0.134607731449403 no 530 0.106601971188538 585 668464 SGTC_2734 clemastine 41.6 µM 1.23976745184744 0.135577470647662 no 531 0.107530710098541 425 26987 Clemastine is a selective histamine H1 antagonist. SGTC_667 1498-1044 59 µM 1.23812698097662 0.135894381946568 no 532 0.107834490482824 609 6739982 SGTC_759 3486-0358 89.3 µM 1.23729219286657 0.136055843506643 no 533 0.10798931261191 635 875103 SGTC_3151 9099821 49.47 µM 1.23456142416167 0.136584935609393 no 534 0.108496886614467 555 17174189 SGTC_165 k038-0023 64.381 µM 1.23450921793525 0.136595064362188 no 535 0.108506606992453 618 46368543 SGTC_3031 9088762 49.47 µM 1.23389501574636 0.136714266919648 no 536 0.108621013528915 609 205253 SGTC_2150 5556613 200 µM 1.22630400180284 0.138193380427565 no 537 0.11004214799152 633 743190 SGTC_2030 5175110 200 µM 1.22361568067715 0.138719807963998 no 538 0.110548620716426 608 2831986 SGTC_515 4092-1064 102 µM 1.2234979583605 0.138742891544752 no 539 0.110570837420113 674 717353 SGTC_322 k048-0136 19.3 µM 1.22096408958358 0.139240379457303 no 540 0.111049808316048 576 6823282 SGTC_1930 st074634 34.3 µM 1.21844330302595 0.139736501971954 no 541 0.111527778952398 616 684253 YOR116C RPO31 SGTC_3055 9094636 49.47 µM 1.21804694264994 0.13981461988482 no 542 0.111603067250434 568 25236176 SGTC_3286 9117135 37.221 µM 1.21630490495012 0.140158306689113 no 543 0.111934396870806 581 3438150 SGTC_2617 dihydrotanshinone i 20.83 µM 1.21452301306053 0.140510449620957 no 544 0.112274033708467 645 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2200 6600604 21.907 µM 1.2142131572642 0.140571745521783 no 545 0.112333168743709 645 2904777 SGTC_2571 chrysanthemic acid 100 µM 1.21118198510258 0.141172331465433 no 546 0.112912832742421 568 2743 An insecticide. SGTC_2236 dapsone 200 µM 1.20946503670996 0.141513292404709 no 547 0.113242117804961 633 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2171 5739187 198.077 µM 1.20713791321088 0.141976315243933 no 548 0.113689518041397 533 2262761 SGTC_302 1094-0063 18.9 µM 1.20705202627221 0.141993423589241 no 549 0.11370605427747 548 5440289 SGTC_1574 spiramycin 23.7 µM 1.2061820989838 0.14216678839229 no 550 0.113873642304023 622 6419898 An antibiotic and protein synthesis inhibitor. SGTC_203 k066-0004 30.888 µM 1.20607779135917 0.142187585112012 no 551 0.113893748563973 724 6795412 SGTC_2110 5483698 200 µM 1.20298813424887 0.142804530691985 no 552 0.114490456165122 614 2848765 YHR062C RPP1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.20211739812773 0.142978726426711 no 553 0.11465902326229 596 756377 SGTC_2977 9011197 71.43 µM 1.20143793290003 0.143114757024003 no 554 0.114790684567515 541 2704722 SGTC_2334 9017922 200 µM 1.20126527634371 0.143149337214557 no 555 0.114824157697472 616 3163164 SGTC_1970 st070122 35.8 µM 1.2003553653239 0.143331670263559 no 556 0.115000677944357 618 102928 SGTC_843 0310-0051 143 µM 1.1966407345143 0.144077655196532 no 557 0.115723308066612 635 2065037 SGTC_545 4218-0007 221 µM 1.19625919596906 0.144154425078513 no 558 0.115797713360326 599 2840508 SGTC_866 0495-0101 262 µM 1.19407888546442 0.144593657346439 no 559 0.116223555882927 592 635694 SGTC_1667 st014849 34.6 µM 1.19074714948955 0.145266588732575 no 560 0.116876431100949 656 5348460 SGTC_606 k015-0008 38.6 µM 1.18940702192987 0.145537855898822 no 561 0.117139769487275 679 1970475 SGTC_928 2764-0428 58.7 µM 1.18478567415302 0.146475915553085 no 562 0.118051099084757 670 662578 SGTC_2470 5664817 21.68 µM 1.18386166130246 0.146663961179992 no 563 0.118233914353985 636 2859561 SGTC_3053 9095903 49.47 µM 1.18335104276822 0.146767946497104 no 564 0.118335025692978 619 17174018 SGTC_1607 st000305 50.6 µM 1.18194271624989 0.1470550025609 no 565 0.118614215563815 635 5457690 SGTC_2348 9022543 33.42 µM 1.1809180473213 0.147264094995326 no 566 0.118817640577428 648 3162678 YDL140C RPO21 SGTC_2813 7971799 71.43 µM 1.17847141073124 0.147764157670787 no 567 0.119304361681576 602 2234054 SGTC_273 hydroxyurea 18.1 mM 1.17663877238252 0.148139470594989 no 568 0.119669857724348 712 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_827 3253-0474 693 µM 1.17449042316572 0.148580250651033 no 569 0.120099322831949 683 5402065 SGTC_1632 st005650 90 µM 1.17145359385161 0.149204815885846 no 570 0.120708250327795 623 2759605 SGTC_2739 tacrine 100.86 µM 1.17056386694908 0.149388131913795 no 571 0.120887064177734 588 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1831 st055328 12 µM 1.17043820521006 0.149414034903967 no 572 0.120912334200322 667 1103068 SGTC_2137 5261020 140 µM 1.16922854414419 0.149663538911576 no 573 0.121155781846874 627 763655 SGTC_718 1130-0073 349 µM 1.16580247637382 0.150371705571506 no 574 0.121847157885732 672 6740020 SGTC_506 n9-isopropylolomoucine 153 µM 1.16577565425998 0.150377258483891 no 575 0.121852581465576 642 6610355 SGTC_3220 9131269 49.47 µM 1.1657279150614 0.150387142143854 no 576 0.121862235015241 629 17722206 SGTC_1887 st057648 70.8 µM 1.16280183906977 0.150993767070165 no 577 0.122454955419439 653 688672 SGTC_1746 st038117 42 µM 1.1600844547121 0.151558583133165 no 578 0.123007211330503 665 2898218 SGTC_1870 st057514 26.5 µM 1.15972948652005 0.151632467867234 no 579 0.123079480496415 653 5393161 SGTC_1108 betulinic acid 729.144 nM 1.15903154851093 0.151777809741182 no 580 0.123221662815071 655 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1352 1496-0991 99 µM 1.15771462724282 0.152052303636187 no 581 0.123490256374325 656 3000039 SGTC_2294 7971431 200 µM 1.15683673884204 0.152235470284785 no 582 0.123669534334902 585 5741572 SGTC_697 0508-1955 564 µM 1.15523331602571 0.152570393726073 no 583 0.123997447520068 710 6243113 SGTC_2809 7964133 12.99 µM 1.15282732212353 0.153073874979119 no 584 0.124490633784133 671 1253665 SGTC_2911 7942208 15.64 µM 1.15275604896197 0.153088806464972 no 585 0.124505264409688 620 1243384 SGTC_3088 9117578 49.47 µM 1.15182493202214 0.153283960994755 no 586 0.124696510239483 637 678341 SGTC_1193 1488-0126 41.5 µM 1.15078011177777 0.153503142984516 no 587 0.124911354386525 664 1384710 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.14886068085369 0.153906341138687 no 588 0.125306716493597 667 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3184 9108758 49.47 µM 1.14759442877754 0.154172715041425 no 589 0.125568015383569 660 902885 SGTC_22 0964-0034 14.468 µM 1.14731564067182 0.154231402969182 no 590 0.12562559605552 695 138402 SGTC_1197 1601-0112 267 µM 1.14526970042847 0.154662547668076 no 591 0.126048726629859 686 7350313 SGTC_2857 9024691 58.44 µM 1.14456054771481 0.154812174397332 no 592 0.126195621483431 611 16478292 SGTC_2537 larixol 68.93 µM 1.14451562957362 0.154821655059816 no 593 0.126204929904644 722 6708759 SGTC_840 0245-0196 390 µM 1.14341211411014 0.155054689373547 no 594 0.126433762577701 723 3827528 SGTC_1626 st003712 1.76 µM 1.14258311888831 0.155229904286573 no 595 0.126605858858323 628 24207035 SGTC_970 1315-0089 19.5 µM 1.13984648256956 0.155809242230281 no 596 0.127175132237814 634 6811083 YLR033W RSC58 SGTC_1857 st056007 79.3 µM 1.13984099066589 0.155810406281775 no 597 0.127176276447928 637 619834 SGTC_2082 5219693 150 µM 1.13579388248753 0.156669781276311 no 598 0.128021418974306 678 2834649 SGTC_1915 st067105 30.6 µM 1.13566674944526 0.156696827532247 no 599 0.128048030752492 675 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1444 4112-3581 28 µM 1.13545226519366 0.156742463831014 no 600 0.12809293579468 678 2877249 SGTC_1125 tnp00248 1.32998 µM 1.1335502803899 0.157147536115047 no 601 0.128491619424457 809 24207736 SGTC_336 4111-0029 111 µM 1.13049122093956 0.157800477325848 no 602 0.129134647807661 618 3131175 SGTC_2450 5739737 12.93 µM 1.12895809099969 0.158128385698015 no 603 0.129457756647465 642 2262825 SGTC_1037 k284-1091 78.7 µM 1.12885079793368 0.15815135044947 no 604 0.129480389734635 627 3334711 SGTC_805 3852-0218 479 µM 1.12241993843825 0.159531793528723 no 605 0.130841965438434 656 6615355 SGTC_97 0535-0701 19.132 µM 1.12056955165615 0.159930452841144 no 606 0.131235565861331 647 2832013 YGL099W LSG1 SGTC_1096 rimcazole 32.2 µM 1.12044986954397 0.159956260345694 no 607 0.131261051870048 651 18528119 A dopamine reuptake inhibitor. SGTC_486 niguldipine 82 µM 1.11905052524408 0.160258208303748 no 608 0.131559292392682 624 1236 A calcium channel blocker. SGTC_526 4469-0568 170 µM 1.11898716184401 0.16027188955343 no 609 0.131572808015871 664 2901964 SGTC_2424 5537928 59.2 µM 1.1167644548332 0.16075229333682 no 610 0.132047525313051 726 5382802 SGTC_2842 9000675 19.48 µM 1.11281924200874 0.161607303344228 no 611 0.132893034785209 639 2989072 SGTC_175 3793-3120 23.7 µM 1.11265787953113 0.161642336952728 no 612 0.13292769599412 635 5322297 SGTC_1414 3917-0015 5.4 µM 1.11173640498781 0.161842494284729 no 613 0.133125751115948 672 6618702 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.11049343031687 0.162112741727643 no 614 0.133393228767093 639 15053 SGTC_408 cantharidin 100 µM 1.10825493703842 0.162600175481574 no 615 0.133875865492924 727 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2147 5545932 89.7195 µM 1.10769340347341 0.162722599319282 no 616 0.133997124600205 669 797404 SGTC_401 neomycin 50 µM 1.10738308761517 0.162790279151453 no 617 0.134064167429698 674 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1677 st019204 53.9 µM 1.10682805179717 0.162911378010994 no 618 0.134184138753639 662 3945625 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.10377849811522 0.163577780616615 no 619 0.134844617148396 736 688751 SGTC_1993 st073995 70.8 µM 1.10109033599558 0.164166676012912 no 620 0.135428671310511 713 3098394 SGTC_752 1896-0090 130 µM 1.10107555823405 0.164169917171188 no 621 0.135431886843384 711 772567 SGTC_3028 9087778 49.47 µM 1.09807905182685 0.164827988525567 no 622 0.136084985877687 694 17217395 SGTC_108 0509-0257 621.132 µM 1.09757283766186 0.164939328136807 no 623 0.136195529520129 747 536624 SGTC_2703 st077852 53.4 µM 1.09636905190881 0.16520429116124 no 624 0.136458650918459 674 6281836 SGTC_3253 9135987 49.47 µM 1.09559432961256 0.165374959451055 no 625 0.136628172149576 642 4182430 SGTC_2730 imipramine 71.33 µM 1.09415290603793 0.165692802880453 no 626 0.136943961021106 833 3696 A tricyclic antidepressant. SGTC_2091 4-phenylthiadiazole 200 µM 1.09407534357362 0.165709917108409 no 627 0.136960967633124 722 270010 SGTC_278 4092-0821 23.9 µM 1.09358047816009 0.16581913651798 no 628 0.137069507501204 711 877900 SGTC_312 4092-0653 6.84 µM 1.09180920474729 0.16621044718003 no 629 0.137458486164914 808 1148278 SGTC_2414 st077232 92.9 µM 1.09071675737492 0.166452088374305 no 630 0.13769876733591 664 729801 SGTC_1565 sinapyl alcohol 95.1 µM 1.08962411573455 0.166693999288791 no 631 0.137939377789909 670 5280507 A phenol propionate derived from cinnamic acid. SGTC_1084 voriconazole 435 nM 1.08499089942373 0.167722312822674 no 632 0.138962842981421 740 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2507 purpurin 79.67 µM 1.08300149377028 0.168165099933457 no 633 0.139403880004746 719 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_201 4262-0159 12.803 µM 1.079249085578 0.169002328196878 no 634 0.140238351610715 640 1341029 SGTC_942 3253-1115 227 µM 1.07776084111708 0.169335121916322 no 635 0.140570249544742 725 46497897 SGTC_1973 st070275 50.2 µM 1.07729079770084 0.169440318000418 no 636 0.140675186063909 700 17118334 SGTC_3353 9151644 39.2805 µM 1.06974653823914 0.17113446505629 no 637 0.142366706178819 737 4909158 SGTC_3279 9140807 49.47 µM 1.06770020214223 0.171595853798378 no 638 0.142827883619989 746 45595718 SGTC_820 1582-0060 59.9 µM 1.06759634671596 0.171619291322006 no 639 0.142851316141085 747 3848840 SGTC_2924 9010168 62.78 µM 1.06497644699435 0.172211212415853 no 640 0.143443294150383 734 2993929 SGTC_2962 9082311 13.18 µM 1.06125587750329 0.173054046668114 no 641 0.144286815809414 681 16459453 SGTC_2270 7924575 90.91 µM 1.06090058836274 0.173134668838206 no 642 0.144367540937039 773 1262135 SGTC_2777 climbazole 1.536 µM 1.05781044780569 0.173836891778209 no 643 0.145070934321675 767 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_141 0443-0274 32.331 µM 1.05691584201009 0.174040525263635 no 644 0.145274998844061 850 1627241 SGTC_2020 4017018 200 µM 1.05279377754249 0.174980762927193 no 645 0.146217758721131 740 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_246 cycloheximide 667 µM 1.05101265610142 0.175388029787885 no 646 0.146626388581764 659 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_982 1491-0518 27.5 µM 1.05005045004201 0.175608295276545 no 647 0.146847459119417 695 3091256 SGTC_1076 itraconazole 331 nM 1.04678576227606 0.176356943993603 no 648 0.147599199221044 786 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_459 nigericin 15.3 µM 1.04487327608249 0.176796446331843 no 649 0.148040771242663 784 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1175 0741-0056 27.6 µM 1.04419096965158 0.17695341241457 no 650 0.148198522056405 826 765927 SGTC_1217 1183-1422 255 µM 1.04318378034771 0.177185279401878 no 651 0.148431592016217 812 2849664 SGTC_2224 6650123 117.647 µM 1.04197642769549 0.177463479148253 no 652 0.148711303927819 721 2908370 SGTC_438 sphingosine 6.67 µM 1.04011768293103 0.177892312181021 no 653 0.149142614611503 656 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_207 4185-0010 4.486 µM 1.03586433482278 0.178876063152175 no 654 0.150132719217188 861 3761753 SGTC_2180 6301957 200 µM 1.03066829372192 0.180082485014533 no 655 0.151348199038693 804 845462 SGTC_473 2-arachidonoylglycerol 10 µM 1.0248125590585 0.181448181902484 no 656 0.152725819655838 757 5282280 An endocannabinoid. SGTC_2560 caryophyllene 100 µM 1.02448975243455 0.181523656188247 no 657 0.152802004300442 845 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3134 9127454 49.47 µM 1.02396805265201 0.181645674519652 no 658 0.152925182408151 803 24262820 SGTC_2247 cerulenin 830 nM 1.0237326100376 0.181700758080039 no 659 0.152980794125606 776 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_909 3448-9333 149 µM 1.02246109725815 0.181998418602747 no 660 0.15328135806844 737 3344074 SGTC_3103 9120822 49.47 µM 1.02081940531689 0.182383188577976 no 661 0.153670004389892 803 17141819 SGTC_2774 tamoxifen 10.92 µM 1.01997366342631 0.182581606726488 no 662 0.153870475699748 779 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_693 4161-2696 114 µM 1.01480391350329 0.18379740210813 no 663 0.155099653940271 736 805759 SGTC_2595 hexamethylquercetagetin 100 µM 1.01341503007519 0.18412489007337 no 664 0.155430981626038 725 386331 SGTC_2796 7949634 45.45 µM 1.0130142039434 0.184219469270733 no 665 0.155526688228147 741 2971588 SGTC_375 3970-0961 9.27 µM 1.01246476746004 0.184349163782636 no 666 0.155657942180143 803 2898222 SGTC_2466 5983409 37.09 µM 1.01223901266722 0.184402469676333 no 667 0.15571189353016 758 2879657 SGTC_3043 9092303 49.47 µM 1.00662163798755 0.1857319473064 no 668 0.157058316086432 726 25236084 SGTC_3007 9078383 71.4286 µM 1.00619405039623 0.185833388443154 no 669 0.157161116795631 799 6496995 SGTC_1449 4112-4002 201 µM 1.00363874282278 0.186440327173751 no 670 0.157776386591317 750 2059539 SGTC_1319 1306-0155 43.7 µM 1.00198921870087 0.186832774841762 no 671 0.158174399978859 822 3122360 SGTC_3274 9138298 49.47 µM 0.997734731863752 0.187847341519313 no 672 0.159204003332178 859 17015756 SGTC_471 1-acyl-paf 4 µM 0.996941532416027 0.188036871245893 no 673 0.159396445271079 782 16759367 SGTC_308 4092-1169 104 µM 0.995744973332794 0.188323004323385 no 674 0.159687036280818 843 2268590 YDL196W YDL196W SGTC_329 k048-0121 21.3 µM 0.995374966115215 0.188411538462782 no 675 0.159776964712685 782 6832902 SGTC_1931 st074438 57.1 µM 0.99461685432732 0.18859301718593 no 676 0.159961323518078 772 2787313 SGTC_2850 9015429 58.44 µM 0.987783653664594 0.190233625646757 no 677 0.161629307403746 757 6457570 SGTC_2858 9025781 8.96 µM 0.985146414268505 0.190869148183622 no 678 0.162276078728771 903 4894980 YPL153C RAD53 SGTC_3153 9100258 49.47 µM 0.984463109818958 0.191034023268003 no 679 0.162443930582975 742 25236848 SGTC_2443 5493264 126.67 µM 0.984314830677256 0.191069813192601 no 680 0.162480369860082 829 5340055 SGTC_430 0958-0115 16.4 µM 0.98380783001133 0.191192218282118 no 681 0.162605004357403 774 6833180 SGTC_3326 9140064 16.379 µM 0.983696067585119 0.191219207532279 no 682 0.162632486953695 790 1868434 SGTC_1713 st033146 12.748 µM 0.981691043211921 0.191703792960506 no 683 0.163126039655469 832 674619 SGTC_2897 9048598 12.99 µM 0.980111880373683 0.192085982713499 no 684 0.163515447703452 784 6467404 SGTC_2811 7967822 32.47 µM 0.979218496110036 0.192302406345277 no 685 0.163736015765723 813 2232244 SGTC_2264 7948757 110.76 µM 0.978218601579174 0.19254480902889 no 686 0.163983109133006 787 2971411 SGTC_355 1311-2252 105 µM 0.977714607692405 0.192667062153192 no 687 0.164107747473172 794 5338538 SGTC_1912 st060209 90.8 µM 0.977252117051615 0.192779289617537 no 688 0.16422217605915 769 688787 SGTC_3138 9097216 49.47 µM 0.977059714525183 0.192825989561925 no 689 0.164269795175954 890 25237486 SGTC_3288 9119690 36.221 µM 0.975842233365088 0.1931216568061 no 690 0.164571326104227 747 17595618 YKL019W RAM2 SGTC_2676 harmalol 100 µM 0.975318178300413 0.193249009577742 no 691 0.164701228044638 862 5459187 A monoamine oxidase inhibitor SGTC_1005 4092-0690 4.4 µM 0.975301956526652 0.193252952515234 no 692 0.16470525013196 769 1529343 SGTC_3208 9114115 49.47 µM 0.974494036392621 0.193449391341339 no 693 0.164905649381283 717 650895 SGTC_2982 9019404 25.97 µM 0.974074341085322 0.19355148470141 no 694 0.165009814322432 689 22333232 SGTC_2727 riluzole 51.77 µM 0.973427722308135 0.193708842838859 no 695 0.165170383174395 773 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2012 4023501 200 µM 0.972451105412003 0.193946655604157 no 696 0.165413089060639 752 3477460 SGTC_1439 4092-1168 46 µM 0.971706077300265 0.194128194526487 no 697 0.165598396267075 841 2886240 SGTC_2343 7990716 14.84 µM 0.969957180923593 0.194554749725317 no 698 0.166033917983046 836 6456862 SGTC_978 1416-0512 87.4 µM 0.96603343338523 0.195513823577111 no 699 0.167013725802505 853 6814003 SGTC_733 4069-0007 56.1 µM 0.964946677682533 0.195779964012299 no 700 0.167285760074169 879 5717425 YNL287W SEC21 SGTC_1921 5740136 50 µM 0.963876272686564 0.196042315077312 no 701 0.16755398048567 876 1774243 SGTC_1380 2291-0730 164 µM 0.963158074819727 0.196218461367572 no 702 0.167734100595435 772 2999191 SGTC_2686 alizarin 95.37 µM 0.961842041254141 0.196541482676519 no 703 0.168064478081524 783 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2138 5575593 77.673 µM 0.960758077340867 0.196807784170167 no 704 0.168336911010657 831 762213 SGTC_711 k292-0785 179 µM 0.957386196441941 0.197637562752148 no 705 0.169186181509917 867 4146315 SGTC_2234 tolnaftate 200 µM 0.956556253260276 0.197842125436668 no 706 0.169395639196247 825 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1107 amlodipine 47 µM 0.954575231955211 0.198330920284401 no 707 0.16989627370415 820 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3122 9126309 49.47 µM 0.953208018544536 0.198668689571782 no 708 0.170242342222038 911 17591206 SGTC_136 0097-0015 404.482 µM 0.952729492881548 0.198786990967335 no 709 0.170363573072481 932 4861337 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.951469976321913 0.199098572331419 no 710 0.170682926288921 805 4620898 SGTC_376 3970-0862 59.1 µM 0.950670485282573 0.199296504362985 no 711 0.170885837702335 873 3135186 SGTC_3344 9148862 3.898 µM 0.948018530043981 0.199953903592639 no 712 0.171560010472452 873 4905352 SGTC_1179 1021-1431 9.29 µM 0.947208205689195 0.200155036533613 no 713 0.171766347424497 894 2840958 SGTC_1985 st071382 65.5 µM 0.946187050554846 0.200408673488534 no 714 0.17202659490149 866 6123237 SGTC_3113 9123498 49.47 µM 0.945610189368335 0.200552040949312 no 715 0.172173722617402 891 8897275 SGTC_1385 3091-4834 14.1 µM 0.940127464031611 0.201917736039302 no 716 0.173576091431902 816 4072814 SGTC_1534 6-azauridine 81.6 µM 0.939048161259874 0.202187234539046 no 717 0.173853008858324 932 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_346 4513-0042 7.16 µM 0.932284038863573 0.203881109415203 no 718 0.175594877083948 882 2827372 SGTC_857 0438-0306 1.35 µM 0.929330448171464 0.204623394007468 no 719 0.176358930153007 890 4686136 SGTC_2884 9058502 51.95 µM 0.928042567525429 0.204947561774093 no 720 0.176692744629353 871 6471554 SGTC_1067 clotrimazole 1.36 µM 0.926364047120154 0.20537051401836 no 721 0.177128410865587 892 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1178 0988-0033 191 µM 0.926292861132093 0.205388462859274 no 722 0.177146902441391 873 5392207 SGTC_1316 1272-0050 65.9 µM 0.926287688093688 0.205389767225916 no 723 0.17714824625943 872 7340392 SGTC_2783 7738165 71.43 µM 0.919963466733504 0.206988078151699 no 724 0.178795925416864 782 17201110 SGTC_2959 9079155 11 µM 0.919898734080403 0.207004475897817 no 725 0.178812840244479 823 16189457 SGTC_91 0417-1751 58.384 µM 0.919802491597972 0.207028856974387 no 726 0.178837990542778 1011 6795624 SGTC_2081 5214970 32.255 µM 0.91730222733712 0.207662843319735 no 727 0.179492145275051 915 2063512 SGTC_1588 farnesol 29.9 µM 0.915446930988475 0.208134027109824 no 728 0.179978525161589 871 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2222 6885208 172.143 µM 0.914282117288523 0.208430173334272 no 729 0.180284312334871 880 609514 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.913029269799165 0.208748978798715 no 730 0.18061357385332 841 6708760 SGTC_2037 5169046 200 µM 0.911215627007896 0.209210995626986 no 731 0.181090885897128 886 5718022 SGTC_889 0919-1524 82.7 µM 0.908632336716607 0.209870114790107 no 732 0.181772115745166 844 3905452 SGTC_952 1185-0122 232 µM 0.90846822719319 0.209912028059572 no 733 0.181815446544788 883 678600 SGTC_3074 9116018 49.47 µM 0.907564340256217 0.210142967268325 no 734 0.18205422089341 865 17027303 SGTC_1360 1598-0022 39.8 µM 0.90713619385016 0.210252408894729 no 735 0.182167390135878 972 761525 SGTC_1313 1220-0047 237 µM 0.906225786125321 0.21048523608365 no 736 0.182408178598668 946 3528706 SGTC_2111 5486399 200 µM 0.90488091842401 0.210829448577082 no 737 0.182764238486227 927 689674 SGTC_2154 5570129 200 µM 0.903622725655491 0.21115177572775 no 738 0.183097743345431 966 673366 SGTC_904 1141-0088 396 µM 0.903128390637871 0.211278494757771 no 739 0.183228878856745 874 1378119 SGTC_2427 5545055 42.75 µM 0.900186363169875 0.212033582250162 no 740 0.184010541014847 961 5372858 SGTC_1286 0929-0070 131 µM 0.899984036193046 0.212085568512113 no 741 0.184064373110837 931 1420408 SGTC_3154 9100113 49.47 µM 0.899334506137477 0.212252510308019 no 742 0.184237256474962 909 25237525 SGTC_1761 st044296 37 µM 0.898880563320091 0.212369227981846 no 743 0.184358140972374 919 1826700 SGTC_1518 st038567 90.8 µM 0.896602640828532 0.212955492934922 no 744 0.184965494203665 904 77966 SGTC_1028 k015-0029 4.8 µM 0.894171179689699 0.213582314686812 no 745 0.18561515489012 911 4588309 SGTC_2219 9098279 200 µM 0.893687865047648 0.213707039386297 no 746 0.185744459940414 917 902349 SGTC_2721 ifenprodil 61.44 µM 0.892298389483515 0.214065845176391 no 747 0.186116508637097 900 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1819 st053448 58.6 µM 0.891296343118402 0.21432482215763 no 748 0.186385104999207 916 2857616 SGTC_2342 7990637 118.86 µM 0.890524119619173 0.214524526129373 no 749 0.186592261584169 934 2033102 YER133W GLC7 SGTC_172 1112-0046 2.638 µM 0.883585224252869 0.216323834366838 no 750 0.188460079083189 843 2802135 YIL048W NEO1 SGTC_2471 5466956 24.79 µM 0.883366457709516 0.216380703884742 no 751 0.188519153729427 915 724419 SGTC_2725 haloperidol 53.21 µM 0.879991178157781 0.217259221670578 no 752 0.189432044305209 952 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2757 clomiphene 4.22 µM 0.879797548194667 0.217309682081497 no 753 0.189484496561523 1016 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1362 1611-0397 101 µM 0.87716862338205 0.217995455348864 no 754 0.190197527891236 940 27816 SGTC_1066 ketoconazole 628 nM 0.875812816723933 0.218349614027252 no 755 0.190565900641445 988 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_776 4476-4378 112 µM 0.875034792324094 0.218552996193581 no 756 0.190777487570916 900 2892008 SGTC_2022 5136654 200 µM 0.874770187327901 0.218622191028311 no 757 0.190849480824638 910 1713771 SGTC_2945 9067681 61.76 µM 0.874692622330506 0.218642476849292 no 758 0.190870587729094 942 16456930 SGTC_1829 berberine 14.4 µM 0.870811693082645 0.21965885119076 no 759 0.191928489806467 947 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1482 3346-2049 8.48 µM 0.867471286567943 0.220535836778077 no 760 0.192841918832232 941 3826804 SGTC_2906 7926292 26.41 µM 0.867194148978863 0.22060868610711 no 761 0.192917820794598 963 2966319 SGTC_3120 9124077 49.47 µM 0.867186784671511 0.220610622102 no 762 0.192919837967169 992 18774327 YGL155W CDC43 SGTC_1015 4130-4525 82 µM 0.866894753181613 0.220687401793782 no 763 0.192999839296966 938 1363237 SGTC_1027 k015-0025 8.67 µM 0.866531943677314 0.220782811459976 no 764 0.193099258309289 942 3598955 SGTC_1269 0831-0796 3.05 µM 0.866226608682334 0.220863125094182 no 765 0.193182952072306 960 927758 SGTC_3276 9139060 49.47 µM 0.865636221237917 0.221018464784198 no 766 0.193344842844528 943 4870619 SGTC_3002 9075603 71.4286 µM 0.864360845336923 0.221354248444087 no 767 0.1936948475004 1000 20105405 SGTC_2699 st077704 54.6 µM 0.86329327893114 0.221635543739914 no 768 0.193988119295715 931 645852 SGTC_1684 st024538 14.6195 µM 0.86276301521029 0.22177533992903 no 769 0.194133888873668 945 6732859 SGTC_1865 st057639 52.2 µM 0.859782229186492 0.222562116899352 no 770 0.194954548482096 994 688818 SGTC_2585 alliin 100 µM 0.859102324223161 0.222741800112456 no 771 0.195142032569918 969 87310 A garlic compound which reacts with lipids. SGTC_3247 9135149 49.47 µM 0.856537705015891 0.223420313449683 no 772 0.195850213133895 910 8934436 YOR116C RPO31 SGTC_1821 st053465 65.6 µM 0.855584925461497 0.22367268665363 no 773 0.196113705534757 924 675086 SGTC_1331 1472-0049 76.2 µM 0.853498247704823 0.224225973813957 no 774 0.196691529489879 927 24051409 SGTC_1224 0823-0416 294 µM 0.849432394703684 0.225306272836835 no 775 0.197820366877001 994 3598164 SGTC_3064 1327-0027 10 µM 0.849412570631097 0.225311547312474 no 776 0.197825880374498 845 16000455 YPR107C YTH1 SGTC_370 0180-0345 38.7 µM 0.849230270563718 0.225360054108511 no 777 0.197876586264626 902 3989527 SGTC_962 1254-0300 21.5 µM 0.847484383535676 0.225824902875941 no 778 0.198362593924594 968 7340576 SGTC_197 4544-0043 41.561 µM 0.847205699709718 0.22589915361431 no 779 0.19844023856735 1021 896523 SGTC_2388 9080168 200 µM 0.84691314419229 0.225977115087991 no 780 0.198521767754891 904 15943073 SGTC_143 4032-1194 15.74 µM 0.846475115868471 0.226093871223512 no 781 0.198643874981354 1030 1806963 SGTC_1706 st031321 9.9705 µM 0.84514055499744 0.226449807569098 no 782 0.199016183767261 1013 6103185 SGTC_3109 9122853 49.47 µM 0.844333970555758 0.22666508237228 no 783 0.199241404179119 1042 1234709 SGTC_1740 st038286 13.222 µM 0.843996618433784 0.226755154817452 no 784 0.199335647617104 960 716786 SGTC_2952 9073731 13.78 µM 0.841213144878836 0.227499107859191 no 785 0.200114268913374 1037 16457353 SGTC_1328 1441-0025 69.2 µM 0.840926654924587 0.227575757423714 no 786 0.200194512404349 938 4562601 SGTC_2090 5301565 104.445 µM 0.84070559814386 0.227634910468284 no 787 0.200256441813962 1011 2056344 SGTC_2892 9047358 58.44 µM 0.839479779867961 0.227963086782763 no 788 0.20060006561785 919 6466771 SGTC_566 0958-0068 16.5 µM 0.836295297632078 0.228816879594292 no 789 0.201494398957299 940 6815365 SGTC_891 0929-0073 133 µM 0.835600850047565 0.229003306326085 no 790 0.201689745193966 1011 5603632 SGTC_1429 4049-0205 9.46 µM 0.835528072252006 0.229022848696248 no 791 0.2017102239567 1024 22774478 SGTC_2638 epoxomicin 18 µM 0.831701184080369 0.230051765887579 no 792 0.202788816069664 1013 9915668 A protesome inhibitor. SGTC_1864 st057645 30.4 µM 0.831632459398779 0.230070267177817 no 793 0.202808217271539 1022 688666 SGTC_1949 st076024 69.1 µM 0.831206008423737 0.230185090150177 no 794 0.202928630561241 1038 2921930 SGTC_2555 cholic acid 100 µM 0.829883404886582 0.230541408200052 no 795 0.203302354218116 977 6708657 Influences liver metabolism. SGTC_1413 3910-0535 34.4 µM 0.829606322143812 0.230616095139489 no 796 0.203380700567066 1030 2876951 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.82956405404493 0.230627489585034 no 797 0.203392653639019 959 803109 SGTC_2124 5246320 200 µM 0.829262711997758 0.230708733144828 no 798 0.203477882845534 966 579342 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.827944227860573 0.231064392047238 no 799 0.203851042950607 944 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_73 0327-0325 16.231 µM 0.826432658020188 0.231472511740193 no 800 0.204279352035464 1076 53298 SGTC_159 3970-0959 50 µM 0.825979126639848 0.231595042301881 no 801 0.204407966314338 1161 6615653 SGTC_527 4476-4215 268 µM 0.825457591483693 0.231735990120572 no 802 0.20455592494981 981 4418754 SGTC_252 miconazole 1.30953 nM 0.824134806495557 0.232093694477561 no 803 0.204931482488267 982 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_446 go6976 132 µM 0.823971631432532 0.232137841174338 no 804 0.204977838604616 998 3501 A protein kinase C inhibitor. SGTC_140 0062-0056 502.533 µM 0.822048731312413 0.232658429990045 no 805 0.205524581323503 1070 3758964 SGTC_3099 9120367 49.47 µM 0.821094162357187 0.232917102306581 no 806 0.205796317461924 1017 24824940 SGTC_864 0469-0573 172 µM 0.820390737071882 0.233107821055125 no 807 0.205996697157048 957 689425 SGTC_2655 perillic acid 100 µM 0.82036568960424 0.233114613739505 no 808 0.206003834381658 991 5702197 An apoptosis inducer. SGTC_298 1391-0729 10 µM 0.818693785092316 0.233568270040372 no 809 0.206480571686351 1003 3237558 SGTC_211 3455-0679 143.504 µM 0.818635724759347 0.233584032982381 no 810 0.206497139107238 1038 748649 SGTC_2866 9034245 58.44 µM 0.818519263956475 0.233615652989304 no 811 0.206530373380474 1028 6462273 SGTC_521 r062-0005 13.8 µM 0.816785327556164 0.234086710723801 no 812 0.207025559289349 968 2832033 SGTC_2692 st077426 47.7 µM 0.816558108120641 0.234148478285696 no 813 0.207090501729769 1037 25238571 SGTC_903 1134-0042 114 µM 0.816403518282542 0.234190507302285 no 814 0.207134692520419 995 701009 SGTC_119 0121-0043 24.815 µM 0.816021740832638 0.234294320702935 no 815 0.207243850674273 1134 1092378 SGTC_3036 9090181 49.47 µM 0.812395351843655 0.235281681952421 no 816 0.208282406260012 1007 25236586 SGTC_1135 dihydrocapsaicin 536.708 nM 0.808797305289339 0.236263592460479 no 817 0.209315873242403 956 107982 A Capsaicinoid. SGTC_38 0929-0051 58.268 µM 0.807931550837435 0.236500194083896 no 818 0.209564993628322 1061 1379719 SGTC_3231 9132313 49.47 µM 0.807794748934619 0.23653759253762 no 819 0.209604374253421 1021 4905967 SGTC_1195 1502-0147 41.1 µM 0.807038011196867 0.236744525787602 no 820 0.209822291981415 1060 817940 SGTC_742 0kpi-0133 140 µM 0.804147051021433 0.237535987512281 no 821 0.210656027016403 1054 2728852 SGTC_786 4544-0069 423 µM 0.802136772505125 0.238087198805178 no 822 0.211236922876688 1041 748821 YLR208W SEC13 SGTC_1225 1216-0074 20.6 µM 0.800532178228717 0.238527675506981 no 823 0.211701263866435 1026 4241466 SGTC_1900 st060200 72.8 µM 0.800263254209566 0.238601541382279 no 824 0.211779144093545 1034 688945 SGTC_524 r073-0010 27.8 µM 0.799252310120224 0.238879331288793 no 825 0.212072062798065 985 2772106 SGTC_406 estrone 100 µM 0.798816510840659 0.238999135910614 no 826 0.21219840766898 1052 5870 A steroid. SGTC_98 0074-0023 107.663 µM 0.798513717875222 0.23908239539659 no 827 0.212286217878246 1058 3563821 SGTC_534 k292-0788 63.4 µM 0.794425648658959 0.240208049140405 no 828 0.213473838726066 1111 4146317 SGTC_1692 fluoroquinolonic acid 71 µM 0.793769980811474 0.240388856293207 no 829 0.213664675813966 1027 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2828 7998861 71.43 µM 0.792887426826669 0.240632346637365 no 830 0.213921706684923 978 2988188 SGTC_2992 9074591 71.4286 µM 0.79252151460171 0.240733338565353 no 831 0.214028326007516 1015 17741321 SGTC_422 cantharidin 155 µM 0.792492306172456 0.240741401098124 no 832 0.214036838077939 1029 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_764 1951-2361 146 µM 0.790700267592537 0.241236346461472 no 833 0.214559459946761 1002 5438930 SGTC_2068 5226020 147 µM 0.789731958703515 0.241504014867964 no 834 0.214842161521769 1125 1810509 SGTC_1608 st001473 40.5 µM 0.789468274426739 0.241576932712772 no 835 0.21491918264869 991 7292267 SGTC_1467 k284-1082 293 µM 0.788238289518599 0.241917224069658 no 836 0.215278668159001 1060 3334705 SGTC_2521 angolensin 13.4 µM 0.787810656766701 0.242035595136595 no 837 0.215403733327533 1042 821428 A flavenoid. SGTC_1984 st072354 53.1 µM 0.787423846382901 0.242142693400893 no 838 0.2155168959143 1043 5762938 SGTC_404 fumagillin 50 µM 0.787163100975354 0.242214901874174 no 839 0.215593197249702 1055 12015870 A methionine aminopeptidase binder. SGTC_593 1203-0218 61.7 µM 0.786066148347631 0.242518809810197 no 840 0.21591436752646 1108 3666956 SGTC_1594 piperine 70.1 µM 0.786015958655571 0.242532719675884 no 841 0.215929068899096 1041 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_741 4582-0002 126 µM 0.785970133376343 0.242545420339951 no 842 0.215942492371139 1035 2912688 SGTC_2565 isoliquiritigenin 100 µM 0.783034815127306 0.243359705825079 no 843 0.216803333890282 952 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_502 l-744,832 89.3 µM 0.781099620215707 0.243897354449063 no 844 0.217371952637559 1069 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2384 9036245 200 µM 0.779694766386923 0.244288061392118 no 845 0.217785280066451 1081 6462766 SGTC_3145 9085516 49.47 µM 0.774629900336586 0.245699458655485 no 846 0.219279191925759 1063 25236195 SGTC_1098 clofazimine 15.1 µM 0.77078145508697 0.246774803424563 no 847 0.220418240604205 1082 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1231 0242-0792 125 µM 0.770337903169823 0.246898903848141 no 848 0.220549739073493 1080 3707635 SGTC_72 0744-0168 198.391 µM 0.770326100458998 0.246902206559026 no 849 0.220553238800636 1030 677577 SGTC_1964 st076914 61 µM 0.76930101263033 0.2471891434509 no 850 0.220857318114257 1121 24208661 SGTC_993 3909-8757 62.7 µM 0.767793619834609 0.247611408182905 no 851 0.221304902795446 997 4288324 YLR208W SEC13 SGTC_3273 9137859 49.47 µM 0.767251973172881 0.247763233273753 no 852 0.221465858582614 1148 2377234 SGTC_1274 0865-0114 173 µM 0.767032603416415 0.247824737375853 no 853 0.221531065562229 1086 870624 SGTC_794 k038-0031 316 µM 0.766663765742941 0.247928165761097 no 854 0.221640726150377 1102 6624242 SGTC_2134 5324836 1.464 µM 0.765973793097226 0.24812170771739 no 855 0.221845947915531 1019 699272 SGTC_45 0kpi-0036 14.9 µM 0.763705772399118 0.248758470172248 no 856 0.222521300040966 1069 2795021 SGTC_2092 5303694 80.6725 µM 0.761387151782173 0.249410337277149 no 857 0.22321292963654 1075 1963699 SGTC_763 3453-1109 128 µM 0.76104261078661 0.249507280456505 no 858 0.223315808323804 1122 1560353 SGTC_2480 5767542 37.17 µM 0.760890314620514 0.249550138267366 no 859 0.223361292003514 1106 2867358 SGTC_1523 st012844 44.7 µM 0.760513539208743 0.249656183804332 no 860 0.223473839693036 1074 4274103 SGTC_2120 5538279 151.968 µM 0.759521248966769 0.249935583903005 no 861 0.22377040393924 1094 2058197 SGTC_2362 9071156 126 µM 0.75928491327755 0.250002153626763 no 862 0.223841070193659 1084 653133 SGTC_1480 1070-0044 41.2 µM 0.757294806896658 0.250563088708568 no 863 0.224436630714979 1105 3124987 SGTC_2690 usnic acid 100 µM 0.756326022419237 0.250836393210882 no 864 0.224726874909245 1147 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1329 1447-1697 50.6 µM 0.755015087156065 0.251206473239559 no 865 0.225119964890346 1065 2840515 SGTC_678 1218-2179 85.9 µM 0.752914295726833 0.251800133075121 no 866 0.22575070848557 1088 6820081 YOR116C RPO31 SGTC_2561 acetosyringone 100 µM 0.751988271956318 0.252062051910048 no 867 0.226029055861801 1148 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2927 9011802 47.9 µM 0.751709387042479 0.252140960556055 no 868 0.226112922033618 1093 43912568 SGTC_1187 1391-0724 117 µM 0.748591182453043 0.253024122497866 no 869 0.227051824146696 1123 6997986 SGTC_2205 7238770 200 µM 0.748013281748915 0.253187978578945 no 870 0.227226073163492 1124 279867 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.747003779018017 0.253474343518605 no 871 0.227530639857013 1113 6708739 YPR165W RHO1 SGTC_2322 7413319 38.22 µM 0.746335727992729 0.253663942628678 no 872 0.22773231700751 1123 1840400 SGTC_1666 st014829 29 µM 0.74595946287118 0.253770762958659 no 873 0.227845951529686 1150 3858230 SGTC_624 k048-0052 28 µM 0.745610022388817 0.253869989016831 no 874 0.227951513405002 1076 6835531 SGTC_3000 9075062 71.4286 µM 0.743978143524174 0.254333641858644 no 875 0.228444848975097 1065 17057871 SGTC_3059 1327-0034 3 µM 0.743574044236476 0.254448523924335 no 876 0.228567105394109 1090 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.743281904095019 0.254531593868295 no 877 0.22865551251438 1106 5377381 SGTC_1290 0986-0249 10.2 µM 0.740658464970758 0.255278204037421 no 878 0.229450274626129 1112 53329 SGTC_1747 st037496 66.6 µM 0.739846670379429 0.255509466135672 no 879 0.229696518367561 1143 723305 SGTC_1950 st077106 7.18 µM 0.738890193212062 0.255782085445843 no 880 0.229986838880039 1071 13831864 SGTC_879 0831-1030 162 µM 0.738109770311506 0.256004637438548 no 881 0.230223873521435 1143 1549252 SGTC_1651 st011928 86.1 µM 0.736438335173344 0.256481617657496 no 882 0.230731991061949 1114 720198 SGTC_2834 9001755 58.44 µM 0.735718338106484 0.256687226999619 no 883 0.230951063608174 1030 2989575 SGTC_52 0329-0193 875 nM 0.732168470676031 0.257702214815396 no 884 0.23203287302306 1179 3739292 SGTC_60 0986-0278 202 µM 0.730762434439105 0.258104807842598 no 885 0.232462136295536 996 3110598 SGTC_2683 piperine 63.03 µM 0.728996578977712 0.258610890207057 no 886 0.233001877563615 1098 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_647 0140-0236 81 µM 0.728531433921395 0.258744283112349 no 887 0.233144166859491 1182 990837 SGTC_364 0083-0097 67.7 µM 0.727521480710722 0.25903403702467 no 888 0.233453280651564 1157 5207356 SGTC_1642 st009582 77.7 µM 0.726553677044848 0.259311855662195 no 889 0.233749707025407 1139 6739311 SGTC_1117 retinoic acid 1.10837 µM 0.726276184186331 0.259391541417291 no 890 0.233834738147977 1161 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2936 9038235 15.59 µM 0.72581705114333 0.259523415336182 no 891 0.233975466245069 1159 4749415 SGTC_2436 5633522 8.09 µM 0.722754608304323 0.260403906469687 no 892 0.234915329592209 1168 5724242 SGTC_1750 st081859 2.357 µM 0.72065926663477 0.261007229066873 no 893 0.235559589890606 1190 5291695 SGTC_2870 9038528 12.99 µM 0.72065070747284 0.261009695023848 no 894 0.235562223596505 1141 6463316 SGTC_544 k015-0020 52.4 µM 0.720260577923115 0.261122106907399 no 895 0.235682286062817 1142 3008304 SGTC_777 1315-0167 517 µM 0.719892399010135 0.26122821675557 no 896 0.235795624162724 1103 4221767 SGTC_1127 asiatic acid 681.4 nM 0.719887662700254 0.261229581913221 no 897 0.235797082357134 1139 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1409 3909-8004 61.9 µM 0.719812938195119 0.261251120416863 no 898 0.23582008886956 1169 2119279 SGTC_2720 fluspirilene 36.88 µM 0.718425137051229 0.261651304355891 no 899 0.236247596097468 1123 3396 An atypical antipsychotic. SGTC_2553 4-methylesculetin 85.09 µM 0.718108263017211 0.261742721698935 no 900 0.236345267837475 1191 5319502 SGTC_1884 5633444 25 µM 0.718032282149672 0.26176464441906 no 901 0.236368691121564 1152 5724239 SGTC_2487 5918373 44.05 µM 0.717372618392944 0.261955016441976 no 902 0.236572105119327 1211 2876279 SGTC_652 0437-0092 114 µM 0.717316347601567 0.261971258885928 no 903 0.236589461245027 1150 3091274 SGTC_1437 4092-1038 11.6 µM 0.71700828415229 0.262060189894111 no 904 0.236684492547507 1174 3977136 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.714659511155568 0.262738736347626 no 905 0.237409731080618 1155 61125 An anti-inflammatory. SGTC_1046 2001-0062 216 µM 0.713065472482969 0.263199755983119 no 906 0.237902621909293 1109 739778 SGTC_271 rotenone 740 µM 0.712777275060737 0.26328315104132 no 907 0.237991794950177 1220 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2988 9073640 71.4286 µM 0.712158418739735 0.26346227373262 no 908 0.238183341215449 1180 9102229 SGTC_510 ag-490 170 µM 0.712155069803628 0.263463243222845 no 909 0.23818437799629 1265 5328779 SGTC_1833 st055984 71 µM 0.71134366301012 0.263698192659001 no 910 0.238435650342682 1171 676288 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.711206138402739 0.263738024616745 no 911 0.238478252646757 1173 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_613 3914-0030 117 µM 0.709112289596066 0.264344855577332 no 912 0.239127398552279 970 1145395 SGTC_2179 6298986 200 µM 0.708063858612889 0.264648974533811 no 913 0.239452801072075 1122 738374 SGTC_3094 9117742 49.47 µM 0.706961473895793 0.264968935697691 no 914 0.239795209888182 1169 17149698 SGTC_3290 9121031 71.43 µM 0.706799161035903 0.265016062717942 no 915 0.239845648010347 1155 17014854 SGTC_1013 4112-3890 241 µM 0.706340246730094 0.265149330057863 no 916 0.23998828524468 1111 705171 SGTC_489 paxilline 115 µM 0.706318485378238 0.265155650334373 no 917 0.239995050137552 1182 105008 A toxic potassium channel blocker. SGTC_3080 9117754 49.47 µM 0.704062179356078 0.265811377423079 no 918 0.24069702592265 1229 9550191 SGTC_2418 pentamidine 31.67 µM 0.703157609769608 0.266074493823979 no 919 0.240978766650496 1182 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3284 9108171 64.8615 µM 0.702933568864345 0.266139682028064 no 920 0.241048574995836 1132 8687505 SGTC_2677 mitomycin C 100 µM 0.701726054430205 0.266491166426156 no 921 0.241425010674725 1199 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3163 9099914 49.47 µM 0.700237021385679 0.266924918565995 no 922 0.241889647503211 1189 16268368 SGTC_3005 9076496 71.4286 µM 0.699207739815391 0.267224954404773 no 923 0.242211107166786 1192 21368410 SGTC_1775 st081588 35.1725 µM 0.697688190552423 0.267668214307326 no 924 0.242686107578038 1225 1426443 YGL099W LSG1 SGTC_1222 0366-0074 1.18 µM 0.696976523872657 0.267875938279351 no 925 0.242908742854988 1211 286520 SGTC_1903 st060211 78.3 µM 0.696601802355817 0.267985346040983 no 926 0.243026013799569 1213 688960 SGTC_2702 st077768 96.8 µM 0.696470767971499 0.268023609571025 no 927 0.243067028880745 1129 6484119 SGTC_2337 9009472 200 µM 0.696146795473814 0.268118225029533 no 928 0.243168451601162 1213 5742383 SGTC_124 0136-0217 7.121 µM 0.69565135630154 0.268262949458886 no 929 0.243323597861263 1309 3976905 SGTC_573 3702-0553 84.7 µM 0.695537789791621 0.268296129296121 no 930 0.243359168630697 1183 1222756 SGTC_290 2043-6722 48.1 µM 0.694755420214221 0.268524764168002 no 931 0.243604295101978 1205 773758 YLR208W SEC13 SGTC_1392 3455-1037 33.9 µM 0.692401533681295 0.269213239585611 no 932 0.244342601476431 1207 981132 SGTC_2059 5238311 157 µM 0.692265133089516 0.269253161774914 no 933 0.244385421028747 1207 703021 SGTC_2389 9091542 195.52 µM 0.691735395203915 0.269408235415681 no 934 0.244551757322769 1181 3626624 YOL127W RPL25 SGTC_2077 5212015 200 µM 0.690531115656462 0.269760938569554 no 935 0.244930124702637 1130 780900 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.688561289617101 0.270338349023146 no 936 0.2455496942213 1180 2346 DNA damaging agent; causes G2/M arrest. SGTC_3250 9135583 49.47 µM 0.688143123389548 0.270461004552861 no 937 0.245681328322095 1208 7699353 SGTC_1655 st012546 55.1 µM 0.686951526628878 0.270810673353426 no 938 0.24605663754324 1180 720985 YLR208W SEC13 SGTC_1845 st056753 3.01 µM 0.686851288353281 0.270840098118608 no 939 0.246088222937363 1173 5375839 SGTC_2227 7312221 64.1025 µM 0.686532558973038 0.270933671156505 no 940 0.246188670012225 1217 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1476 4112-3294 3.34 µM 0.685758646966568 0.271160944491517 no 941 0.246432658670015 1237 704369 SGTC_2243 6634756 200 µM 0.685536105321104 0.271226315486184 no 942 0.246502842613404 1250 885676 SGTC_1030 k029-0042 36.7 µM 0.684812071142806 0.271439052875329 no 943 0.246731258558724 1211 6080581 SGTC_1105 epirubicin 18.1 µM 0.683031803520063 0.271962488440394 no 944 0.247293373173603 1183 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1690 st023502 41.2 µM 0.682525661023093 0.272111396425222 no 945 0.247453311184246 1186 24207482 SGTC_1550 gossypolone 36.6 µM 0.681891329947903 0.272298074921859 no 946 0.247653834045393 1225 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1210 3013-0140 750 nM 0.680746156995266 0.272635251095426 no 947 0.24801606238209 1235 905973 SGTC_1162 k048-0130 20.1 µM 0.67995959361351 0.272866960930319 no 948 0.248265023004702 1204 6797406 SGTC_929 2805-0021 398 µM 0.679814218205643 0.272909797047837 no 949 0.2483110513671 1234 3098024 SGTC_2913 7966556 36.57 µM 0.679109031219584 0.273117633784762 no 950 0.248534390278988 1160 2976516 SGTC_3196 9111891 49.47 µM 0.678981752429572 0.273155154471675 no 951 0.248574711988515 1234 18891510 SGTC_946 3434-1334 87.4 µM 0.677274976874517 0.273658543787761 no 952 0.249115752192819 1187 4047976 SGTC_2379 9035213 200 µM 0.676830518212618 0.273789705865807 no 953 0.249256746329034 1245 646551 SGTC_2132 5317594 122.667 µM 0.676241263939561 0.273963645804111 no 954 0.24944373889212 1210 794577 SGTC_836 0330-0104 1.35 µM 0.674858755174044 0.274371958083177 no 955 0.249882753456816 1242 46494820 SGTC_319 1348-1596 45.5 µM 0.674718386246046 0.274413431651879 no 956 0.24992735042217 1284 5380505 SGTC_3037 9091026 49.47 µM 0.674490759476595 0.274480693101679 no 957 0.249999679274407 1242 25236398 YIL048W NEO1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.672954219991111 0.274934937953387 no 958 0.250488208108763 1247 229346 A bile salt which induces apoptosis. SGTC_3067 9117431 49.47 µM 0.672758596068378 0.274992796529984 no 959 0.250550441248278 1227 17150885 SGTC_378 3970-0959 8.33 µM 0.672545664864476 0.2750557808003 no 960 0.250618189601217 1234 6615653 SGTC_3089 9117425 49.47 µM 0.671716852993535 0.27530100795254 no 961 0.250881985166949 1180 9401657 SGTC_1021 4476-0760 85.3 µM 0.670565144279713 0.275641951717257 no 962 0.25124879673333 1213 746768 SGTC_2461 5755302 26.15 µM 0.668533358634091 0.276243932969546 no 963 0.251896597756125 1244 2788904 SGTC_1267 0828-0272 9.49 µM 0.667557566510864 0.276533271623007 no 964 0.252208025905039 1269 745334 SGTC_460 trequinsin 123 µM 0.6672714413658 0.276618140665842 no 965 0.252299382428329 1282 5537 A vasodilator. SGTC_1174 0739-0097 51.1 µM 0.665693750885977 0.277086336642223 no 966 0.252803434318125 1260 728447 SGTC_3172 9105863 49.47 µM 0.665488762271866 0.277147197590829 no 967 0.252868964448466 1224 2348785 SGTC_1246 0422-0085 105 µM 0.664759644534001 0.277363725031438 no 968 0.253102119007332 1235 264295 SGTC_3355 9151058 44.0485 µM 0.664350491379722 0.277485268219918 no 969 0.253233005998757 1249 17015728 SGTC_2141 5621638 7.665 µM 0.664288337973569 0.277503733811245 no 970 0.253252891819378 1261 2856238 SGTC_1486 3970-0793 4.53 µM 0.663182208675143 0.277832461934681 no 971 0.253606932301669 1270 2844330 SGTC_2204 7233102 200 µM 0.661899692999578 0.278213847784805 no 972 0.254017754277655 1183 2172480 SGTC_1724 st037281 8.293 µM 0.661885404206273 0.278218098327182 no 973 0.254022333302864 1258 574124 YDL195W SEC31 SGTC_20 0481-0013 4.944 µM 0.658771456081646 0.279145171083906 no 974 0.255021269704509 1235 182045 SGTC_129 0088-0017 176.636 µM 0.654721647358966 0.280353106800951 no 975 0.256323492585391 1188 182446 SGTC_229 benomyl 22.8748 µM 0.654424568898592 0.280441815892179 no 976 0.256419154931936 1253 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2467 5474540 200 µM 0.65418883945834 0.280512215531509 no 977 0.256495075492786 1245 5413519 SGTC_277 nystatin 15.5 µM 0.654143078938846 0.280525882715985 no 978 0.256509814781281 1242 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2782 7736369 71.43 µM 0.652032145892746 0.281156700096932 no 979 0.257190217581625 1301 2950836 YOL077C BRX1 SGTC_2099 5377090 177.372 µM 0.651618720214512 0.281280325695104 no 980 0.257323584087982 1261 2243829 SGTC_1164 k060-0068 93.7 µM 0.651408099969244 0.281343317004389 no 981 0.257391541643751 1285 5963676 SGTC_2198 6589944 200 µM 0.649320562188908 0.281968015860058 no 982 0.25806559888527 1239 5290268 SGTC_1354 1498-1681 81 µM 0.648298243887095 0.282274189698984 no 983 0.258396034818682 1305 5754243 SGTC_1241 0364-0022 50.8 µM 0.648025048686244 0.282356035937376 no 984 0.258484374664977 1289 4563895 SGTC_2666 tannic acid 100 µM 0.644514487606694 0.283408775561811 no 985 0.2596209330522 1294 16134267 A thiamine antagonist. SGTC_1242 0402-0103 60.1 µM 0.644199087540567 0.283503449110821 no 986 0.259723171265376 1245 432868 SGTC_466 geldanamycin 89.2 µM 0.643407952357741 0.283740990604076 no 987 0.259979712348449 1190 5288382 HSP90 inhibitor. SGTC_2589 lobaric acid 100 µM 0.643026394389839 0.283855588963731 no 988 0.260103486690269 1255 73157 A novel microtubule depolymerizer. SGTC_1471 k673-0312 37 µM 0.642717095886432 0.28394850093732 no 989 0.260203842931219 1274 24099884 SGTC_916 4466-0038 42 nM 0.642079064162231 0.284140208953941 no 990 0.260410924303077 1328 5722064 YGL116W CDC20 SGTC_147 4466-0538 29.23 µM 0.640967105893453 0.284474464522683 no 991 0.260772027379631 1344 6742687 YHR072W ERG7 SGTC_922 1866-0035 480 µM 0.640860799340553 0.284506430194487 no 992 0.260806563406905 1274 3156169 SGTC_2405 ticlatone 3.52 µM 0.63991387964313 0.284791238312351 no 993 0.261114294942515 1182 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_448 monastrol 171 µM 0.636132989897914 0.285929782902945 no 994 0.262344872386949 1263 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_126 0417-1624 672.48 µM 0.633916925355302 0.286598113741175 no 995 0.263067519610937 1366 41912 YDL195W SEC31 SGTC_619 1652-1634 108 µM 0.633056556839863 0.286857787120738 no 996 0.26334835523391 1257 5400454 SGTC_2658 polymyxin b sulfate 77.05 µM 0.632803151043455 0.286934290411141 no 997 0.263431099399669 1264 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2735 sertaconazole 140 nM 0.631910966257437 0.287203718179641 no 998 0.263722528569878 1364 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1386 3228-0095 33.8 µM 0.63002308090572 0.287774228533167 no 999 0.264339741645173 1307 870181 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.629077948893636 0.288060044084505 no 1000 0.264649013021493 1289 16623 A steroid. SGTC_1852 st056254 31.4 µM 0.628298073804547 0.288295985445214 no 1001 0.264904346617119 1244 442583 SGTC_3087 9117406 49.47 µM 0.628017495486636 0.288380893158509 no 1002 0.264996239470194 1285 42546093 SGTC_614 0462-0418 107 µM 0.625385392336362 0.289177985250817 no 1003 0.26585907355975 1211 5188303 SGTC_5 0352-0601 109.883 µM 0.624810846981297 0.289352115138078 no 1004 0.26604760535543 1217 762456 SGTC_3119 9125183 49.47 µM 0.623228269156173 0.289832008263272 no 1005 0.266567263681338 1172 22695334 SGTC_1333 1482-0047 286 µM 0.622664686960085 0.290002996268674 no 1006 0.266752446489858 1280 3811116 SGTC_691 1548-0686 185 µM 0.621845115276842 0.290251734556299 no 1007 0.267021858740015 1257 46495133 SGTC_342 k048-0088 23.3 µM 0.621242949453764 0.290434554284214 no 1008 0.267219892164393 1286 6820570 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.620518943365983 0.290654436500789 no 1009 0.267458093122562 1251 1241132 A phosphatase inhibitor. SGTC_618 k072-0232 33.2 µM 0.620247504392976 0.290736893169535 no 1010 0.267547425244347 1314 5872756 YGL099W LSG1 SGTC_949 1165-0505 146 µM 0.620073517466386 0.290789751989481 no 1011 0.267604693249771 1314 6244267 SGTC_264 promethazine 12.5 mM 0.619417175248138 0.290989195194887 no 1012 0.26782078468636 1338 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2621 lithochol-11-enic acid 100 µM 0.618567760647851 0.291247402288495 no 1013 0.268100572922418 1314 6708711 SGTC_769 0302-0231 76 µM 0.615991350778867 0.292031239022386 no 1014 0.268950114136687 1323 571869 YER009W NTF2 SGTC_3312 9133330 71.43 µM 0.614489164603009 0.292488710956545 no 1015 0.26944606551664 1365 17617324 SGTC_1847 st056231 15 µM 0.612397487638361 0.293126259120143 no 1016 0.27013740181888 1332 5393180 SGTC_2512 diallyl trisulfide 49.23 µM 0.611238775417612 0.293479714558158 no 1017 0.270520758267514 1308 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1901 st060216 58.6 µM 0.60846892581519 0.294325432889156 no 1018 0.271438254715957 1315 688792 SGTC_1307 1187-1599 12.2 µM 0.607562583088771 0.29460241074679 no 1019 0.271738811705824 1318 1538471 SGTC_12 0849-0099 9.267 µM 0.606112537809744 0.295045793731919 no 1020 0.272220012945783 1308 6071388 SGTC_1087 pterostilbene 9.05 µM 0.605975594336861 0.295087683067268 no 1021 0.27226547986427 1415 5281727 Similar to reservatol, lowers cholesterol. SGTC_1886 st057356 49.9 µM 0.604858742816318 0.295429416516636 no 1022 0.272636429137382 1262 24207747 SGTC_402 epigallocatechin gallate 10 µM 0.604761025172018 0.295459324751992 no 1023 0.272668896849042 1321 65064 An antioxidant. SGTC_1678 st019265 80.2 µM 0.604699709038462 0.295478092364019 no 1024 0.272689270756922 1383 5367020 SGTC_577 r071-0003 38.6 µM 0.604604966424953 0.295507092214636 no 1025 0.272720752982683 1348 4568517 YMR134W ERG29 SGTC_1942 st076330 65.2 µM 0.604142252796719 0.295648743442101 no 1026 0.272874534992713 1362 24208414 SGTC_707 0865-0008 204 µM 0.603803617003696 0.295752430307009 no 1027 0.272987107214115 1367 723043 SGTC_2323 6148992 148.28 µM 0.603028293778234 0.2959898893562 no 1028 0.273244933500813 1294 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2401 5128683 200 µM 0.601886331161657 0.296339798736183 no 1029 0.27362490174456 1272 708373 SGTC_2338 7999974 200 µM 0.6007409568203 0.296690943893399 no 1030 0.274006267606114 1381 315925 SGTC_2354 9060492 162 µM 0.597061857751996 0.297820157030543 no 1031 0.275233041117124 1374 6471895 SGTC_2231 micatex 6.853 µM 0.596844286880069 0.297886996647515 no 1032 0.275305673409801 1356 20737 An antifungal of unknown mechanism. SGTC_1262 0737-0114 49.6 µM 0.589467942805633 0.300157106804344 no 1033 0.277773705336077 1372 765919 SGTC_2588 indole-3-carbinol 100 µM 0.589002211097144 0.300300700493381 no 1034 0.277929895178878 1397 3712 Induces cell cycle arrest. SGTC_1155 4088-0394 48.2 µM 0.588179166854789 0.30055453612182 no 1035 0.278206019693916 1313 2326248 SGTC_3068 9116768 49.47 µM 0.58655210559367 0.301056624033941 no 1036 0.278752278549872 1338 41904888 SGTC_2894 9048625 32.47 µM 0.585209289091731 0.301471282583716 no 1037 0.279203499836068 1451 4092861 SGTC_3191 9110352 49.47 µM 0.583392975258212 0.302032564544424 no 1038 0.27981439284138 1392 17122424 SGTC_2156 5649887 115 µM 0.583073029869374 0.302131483485059 no 1039 0.279922069347414 1422 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2726 cimetidine 79.27 µM 0.582974249221358 0.302162026875989 no 1040 0.279955317689363 1356 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2265 7929201 200 µM 0.582652705238837 0.302261459222282 no 1041 0.280063558668279 1332 1265108 SGTC_3314 9135860 59.4275 µM 0.582210470220489 0.302398237322744 no 1042 0.280212460857276 1355 25252478 SGTC_297 0986-0032 24 µM 0.580539853883842 0.302915189656429 no 1043 0.28077530950006 1331 2847425 SGTC_450 aminopyrene 156 nM 0.580363534428472 0.302969772683535 no 1044 0.280834745304813 1379 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_829 1635-0120 117 µM 0.580091206090814 0.3030540857269 no 1045 0.280926556847422 1416 285054 SGTC_2635 hydroquinidine 100 µM 0.575009375434417 0.304629345484979 no 1046 0.282642478156116 1396 442912 An experimental heart treatment. SGTC_2239 6685329 187.64 µM 0.574133300219331 0.304901277850549 no 1047 0.282938800328745 1387 805680 SGTC_1431 4049-0260 9.09 µM 0.574091627931076 0.30491421554988 no 1048 0.282952899207364 1385 3854841 SGTC_2949 9072542 2.23 µM 0.572046514488323 0.305549446827986 no 1049 0.283645231346096 1370 16457352 SGTC_994 3910-0338 138 µM 0.5686760898838 0.306597609744562 no 1050 0.284787988469496 1482 3479481 SGTC_295 k015-0027 31 µM 0.566681561632102 0.307218631490147 no 1051 0.285465275099506 1361 3887424 SGTC_2905 7799065 20.05 µM 0.566089753196988 0.307403005095588 no 1052 0.285666384309458 1389 1296806 SGTC_1144 3486-0183 12.5 µM 0.565207793396845 0.307677863564523 no 1053 0.285966218209347 1380 6744069 SGTC_648 0375-0473 33.3 µM 0.56394595857548 0.308071295976267 no 1054 0.286395455566193 1396 1713139 SGTC_806 3966-4455 5.86 µM 0.563805733512893 0.308115030928083 no 1055 0.286443174688432 1324 714982 SGTC_753 1322-0200 289 µM 0.563244336165688 0.308290153061785 no 1056 0.286634258123214 1388 5403907 SGTC_1910 st062352 60.4 µM 0.561555042643542 0.308817373924826 no 1057 0.287209609167586 1301 2245730 SGTC_2474 5321570 43.32 µM 0.559352588421705 0.309505341897929 no 1058 0.287960555855752 1451 2841384 SGTC_2005 4024620 188 µM 0.557218683704817 0.310172534819535 no 1059 0.288689012923385 1386 236743 SGTC_2330 7979373 200 µM 0.555056367023321 0.310849249118147 no 1060 0.289428053127095 1323 1863007 SGTC_1469 k284-2957 126 µM 0.554510097509872 0.31102030992733 no 1061 0.289614898559264 1445 23884841 SGTC_1412 3909-8563 178 µM 0.554386571475717 0.311058996978577 no 1062 0.289657157118775 1478 23767530 SGTC_1530 rhein 70.4 µM 0.552980495575394 0.311499512182109 no 1063 0.290138382984931 1431 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2448 5185112 27.17 µM 0.552778365772157 0.311562860454697 no 1064 0.290207592178892 1374 5718189 SGTC_1045 1348-1485 165 µM 0.552599124979559 0.311619039888165 no 1065 0.290268970650791 1396 6810614 SGTC_2473 5854593 8.94 µM 0.551738791482869 0.31188875519883 no 1066 0.290563664278657 1403 2872951 SGTC_516 3992-2719 87.3 µM 0.55170300456931 0.311899976614782 no 1067 0.290575925551864 1324 5350887 YDR037W KRS1 SGTC_941 3237-0776 460 µM 0.551616290220832 0.311927167662824 no 1068 0.290605636531111 1483 760008 SGTC_1140 3229-1848 2.98 µM 0.551095619559765 0.312090456091244 no 1069 0.290784064052806 1416 2849525 SGTC_2576 guaiol 23.12 µM 0.549034534469706 0.312737198723915 no 1070 0.291490875131473 1439 227829 SGTC_841 0251-0215 91.2 µM 0.548028375720615 0.313053128409036 no 1071 0.291836209523264 1437 3888614 SGTC_1714 st033236 13.627 µM 0.541298017852759 0.315169954960937 no 1072 0.294151093243869 1517 2916566 SGTC_444 curcumin 90.4 µM 0.541154653589569 0.315215112181158 no 1073 0.294200495059609 1421 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2520 obtusaquinone 4.71 µM 0.540151567029628 0.315531144010901 no 1074 0.294546255314365 1512 5967872 SGTC_780 0109-0199 192 µM 0.538920829492373 0.315919083802566 no 1075 0.294970742008254 1544 610414 SGTC_1512 0259-0544 12.2 µM 0.538098377851015 0.316178441214449 no 1076 0.295254566152613 1437 18476 SGTC_1184 1269-1718 139 µM 0.536759059691914 0.316600984364828 no 1077 0.295717027290261 1531 5403821 SGTC_2990 9074105 71.4286 µM 0.53402127184402 0.317465477047717 no 1078 0.296663408490262 1437 6502001 SGTC_2944 9067346 25.62 µM 0.533849540038225 0.317519736896613 no 1079 0.296722817859684 1445 6473075 SGTC_874 0599-0792 117 µM 0.533696032457388 0.317568241994645 no 1080 0.29677592730152 1501 765305 SGTC_465 cgp-37157 41 µM 0.533634301822669 0.317587748432213 no 1081 0.296797285646522 1408 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3130 9127414 49.47 µM 0.533442189012737 0.317648457941865 no 1082 0.296863759765742 1425 1494646 SGTC_715 0868-0130 184 µM 0.529509378938717 0.318892339793114 no 1083 0.298226069988526 1579 2876258 SGTC_640 3381-0960 37.1 µM 0.528981735936192 0.319059380139064 no 1084 0.298409059887024 1528 1745025 SGTC_395 anisomycin 6.25 µM 0.526908439648614 0.319716096483658 no 1085 0.299128586388567 1409 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_824 1304-0008 100 µM 0.525927965516187 0.320026858667492 no 1086 0.299469128788057 1445 768245 SGTC_1520 flindersine 88 µM 0.525354193302777 0.320208774908384 no 1087 0.299668495252589 1588 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_956 1185-0240 191 µM 0.524265707841725 0.320554001316159 no 1088 0.300046872312957 1456 1416193 SGTC_289 k017-0060 526 µM 0.524189227248107 0.320578263909653 no 1089 0.300073466463261 1446 5512909 SGTC_797 k781-0471 270 µM 0.524024511127205 0.320630520818449 no 1090 0.300130745859015 1503 23738129 SGTC_1652 st011932 78 µM 0.522908696144053 0.320984611568432 no 1091 0.300518896350884 1495 1551076 SGTC_1802 st050112 57.9 µM 0.522739190041156 0.321038416592607 no 1092 0.300577881043299 1437 4662563 SGTC_2100 5377183 190 µM 0.522454789673202 0.321128700064837 no 1093 0.300676858355003 1537 2844202 SGTC_837 0091-0265 12.5 µM 0.522295645129551 0.321179225436579 no 1094 0.300732250422691 1403 759367 SGTC_2797 7859098 81.82 µM 0.522256478496486 0.321191660606743 no 1095 0.300745883520674 1452 972681 SGTC_2873 9040596 71.43 µM 0.521724844617683 0.321360470987298 no 1096 0.300930961896326 1432 6463863 SGTC_1215 3852-0577 11.2 µM 0.521126422269276 0.321550532949804 no 1097 0.301139352846408 1558 2884876 SGTC_595 3909-8003 73.7 µM 0.517793386257475 0.322609975700225 no 1098 0.302301216642668 1484 699517 SGTC_1769 st044406 64.4 µM 0.515524913985959 0.323331860200074 no 1099 0.303093132263412 1461 670903 SGTC_2740 felodipine 17.08 µM 0.514899385678321 0.323531036117561 no 1100 0.303311665094524 1534 3333 L-type calcium channel blocker SGTC_2802 7925815 54.55 µM 0.514020515518311 0.323810964633312 no 1101 0.303618823654486 1435 1262923 SGTC_2883 9059145 45.46 µM 0.513692884312013 0.323915343810313 no 1102 0.303733363838584 1433 16476510 SGTC_2819 7996655 46.38 µM 0.513232008735953 0.324062196405178 no 1103 0.303894519014242 1478 6456960 SGTC_3229 9132204 49.47 µM 0.51249094578826 0.324298384824163 no 1104 0.304153727725935 1500 17682924 SGTC_1723 st034307 2.5525 µM 0.511530167632701 0.324604705199445 no 1105 0.304489934902933 1469 867466 SGTC_1022 4477-0945 21.3 µM 0.511499036916098 0.324614632445367 no 1106 0.304500831307477 1447 4648966 SGTC_1250 0485-0349 40.2 µM 0.511135414209032 0.32473059698608 no 1107 0.304628119738421 1463 6842794 YDL195W SEC31 SGTC_3200 9114385 49.47 µM 0.505480752051806 0.326536131080017 no 1108 0.306610607082157 1427 17018030 YLR208W SEC13 SGTC_2824 7998404 51.95 µM 0.500222895008139 0.328218620072591 no 1109 0.308459069495443 1506 837851 SGTC_214 4373-3496 70 µM 0.49952554569202 0.328442031421146 no 1110 0.308704597445342 1523 3779166 SGTC_2984 9022109 38.96 µM 0.498848731749834 0.328658922480747 no 1111 0.308942976949969 1522 6459207 SGTC_1309 pyrazolanthrone 13.4 µM 0.498818262795385 0.328668687887261 no 1112 0.308953710263469 1577 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1711 st032263 62.8 µM 0.49793080213419 0.328953173444575 no 1113 0.309266408007445 1523 3958979 SGTC_3241 9133421 49.47 µM 0.497520413010273 0.329084761846124 no 1114 0.30941105581344 1508 17018221 SGTC_1229 0139-0193 12.2 µM 0.497010645726712 0.32924824465427 no 1115 0.309590772072774 1578 3090752 SGTC_82 0054-0107 293.755 µM 0.496970914631379 0.329260987822964 no 1116 0.309604781012642 1562 3104697 SGTC_931 2812-0076 566 µM 0.496201812951206 0.329507705025121 no 1117 0.309876016018269 1478 3450959 SGTC_148 3253-0744 288.01 µM 0.495835356203207 0.329625285409182 no 1118 0.310005288798234 1445 6893655 SGTC_2071 5230951 39.92 µM 0.492793451801177 0.330601952410358 no 1119 0.311079269017143 1495 1799272 SGTC_1411 3909-8223 150 µM 0.492461690442258 0.330708541278062 no 1120 0.311196498852593 1574 X1411 SGTC_3305 9127027 53.8275 µM 0.491536443254144 0.331005878822142 no 1121 0.311523541581263 1486 41905295 SGTC_729 4092-0585 94.1 µM 0.487425887163367 0.332328134441989 no 1122 0.312978275990199 1458 2169061 SGTC_2314 7727897 200 µM 0.48536465323194 0.332991965863413 no 1123 0.3137088505045 1471 900724 SGTC_1963 st076565 50.3 µM 0.484742433988538 0.333192457906808 no 1124 0.313929530903481 1502 4914280 SGTC_3072 9116419 49.47 µM 0.483694426658994 0.33353025553005 no 1125 0.314301374581778 1452 17170162 SGTC_2097 5376186 200 µM 0.48322044884941 0.333683074179351 no 1126 0.314469608674394 1558 742755 SGTC_2712 st079126 47.7 µM 0.482814885431946 0.333813856754671 no 1127 0.314613590298741 1459 3152970 SGTC_1841 st054148 70 µM 0.482625381004032 0.333874973422288 no 1128 0.314680877126462 1459 675442 SGTC_2232 chlorophetanol 41.5365 µM 0.481806701065671 0.334139054764347 no 1129 0.314971634311178 1593 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1810 st050138 53 µM 0.481764961315375 0.334152520944626 no 1130 0.314986461411252 1527 3444541 SGTC_3341 9147222 25.867 µM 0.481553180062759 0.334220849619412 no 1131 0.315061696494134 1508 1939759 SGTC_2346 9031566 143.75 µM 0.479307349978757 0.33494577735692 no 1132 0.3158599970517 1583 4771086 SGTC_2417 cerulenin 830 nM 0.478953064942536 0.335060192697801 no 1133 0.315986009457537 1542 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3321 9137793 26.8275 µM 0.478861198377918 0.335089863242207 no 1134 0.316018688128004 1502 4904192 SGTC_320 4092-0846 5.34 µM 0.477397640959717 0.335562693439374 no 1135 0.316539496864457 1569 1359356 SGTC_3308 9128332 17.569 µM 0.477165489610614 0.335637718327862 no 1136 0.316622141684142 1626 17332805 YDL196W YDL196W SGTC_56 0957-0365 83.25 µM 0.472430734855865 0.337169285959105 no 1137 0.318309685402756 1479 6752360 SGTC_2439 5492030 7.2 µM 0.471863323988676 0.337353010175523 no 1138 0.318512174029851 1562 5722370 SGTC_1671 st016596 74.5 µM 0.471371412060875 0.337512319682135 no 1139 0.318687763669541 1514 2829167 SGTC_101 0490-5701 117.494 µM 0.4690262659185 0.338272213526541 no 1140 0.319525430809587 1585 4661669 SGTC_1341 1486-1360 280 µM 0.468944506054789 0.338298717950008 no 1141 0.319554651419521 1496 3976547 SGTC_2002 4023503 131 µM 0.467589209898085 0.338738186388808 no 1142 0.320039191308031 1644 4736863 YCR052W RSC6 SGTC_816 0325-0417 81.3 µM 0.466954292168286 0.338944140445317 no 1143 0.320266290170496 1507 68101 SGTC_771 0250-0039 27.3 µM 0.46649934095808 0.339091746735797 no 1144 0.3204290596042 1531 3005115 SGTC_639 0833-0042 114 µM 0.465880377310526 0.339292605576265 no 1145 0.320650563794067 1496 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2624 nerol 100 µM 0.464398104183721 0.339773801072009 no 1146 0.321181274054478 1621 637566 A natural product oil. SGTC_1752 st044819 83.042 µM 0.463906997783704 0.339933288307408 no 1147 0.321357189502139 1457 441209 YML126C ERG13 SGTC_150 3970-0969 77.2 µM 0.460909757423944 0.340907264882347 no 1148 0.322431675498078 1576 6615640 SGTC_1660 st012960 28.1 µM 0.46003792383456 0.341190773541028 no 1149 0.322744499873045 1522 24207266 SGTC_1572 epiandrosterone 68.9 µM 0.459569646840781 0.341343088003319 no 1150 0.322912575104756 1572 441302 A steroid. SGTC_1777 st045864 34.765 µM 0.45888399763934 0.341566152823917 no 1151 0.323158735403093 1535 4691462 SGTC_2724 maprotiline 69.64 µM 0.454186108476492 0.343096019899734 no 1152 0.32484744030527 1601 4011 A tricyclic antidepressant. SGTC_2979 9012552 45.46 µM 0.453004498714955 0.343481217334848 no 1153 0.325272751048942 1586 17100905 SGTC_591 4299-0174 154 µM 0.451327798020451 0.344028090360114 no 1154 0.325876656428858 1567 5509088 SGTC_3041 9091929 49.47 µM 0.451319145914753 0.344030913180064 no 1155 0.325879773886319 1591 25236887 SGTC_2106 5357045 167.29 µM 0.451097029349158 0.344103383494065 no 1156 0.325959809316212 1623 668842 SGTC_3188 9110789 49.47 µM 0.450326528501758 0.344354820362123 no 1157 0.326237506609624 1618 849217 SGTC_1838 st055369 84.5 µM 0.449824073872333 0.344518823013646 no 1158 0.326418648910704 1519 676036 SGTC_645 0845-0943 5.41 µM 0.449070654500868 0.344764796059559 no 1159 0.326690344420053 1540 1885106 SGTC_1453 4237-0541 195 µM 0.4489815506009 0.34479389065141 no 1160 0.326722482844912 1664 739892 SGTC_3285 9112818 20.8695 µM 0.448346215570139 0.345001369597725 no 1161 0.326951675807613 1570 17017947 YPR165W RHO1 SGTC_926 2268-1401 59.4 µM 0.447817183646233 0.34517416911016 no 1162 0.327142570443335 1526 2931578 SGTC_3239 9133757 49.47 µM 0.446900687316828 0.345473603848043 no 1163 0.32747338385071 1604 17036923 SGTC_513 4245-1575 41.7 µM 0.445969968055306 0.345777784451312 no 1164 0.327809469781514 1646 719745 SGTC_654 1124-0271 80.9 µM 0.445068977159192 0.346072344001207 no 1165 0.328134953614707 1521 5403748 SGTC_2779 methotrexate 400 µM 0.444118918770456 0.346383046020599 no 1166 0.328478304526922 1557 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_581 0958-0271 211 µM 0.442898672903265 0.346782260377955 no 1167 0.328919513682575 1509 4591145 SGTC_2402 5553605 200 µM 0.442617642564016 0.346874226093897 no 1168 0.329021160751369 1636 6758546 SGTC_1547 harmine 94.2 µM 0.442311655632336 0.34697436898398 no 1169 0.329131848855655 1563 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2961 9083290 32.55 µM 0.441952024091579 0.347092082255866 no 1170 0.329261961580637 1582 17741490 SGTC_700 3453-2283 142 µM 0.441123657026402 0.347363276434642 no 1171 0.329561738915824 1642 565664 SGTC_888 0916-0002 6.97 µM 0.440203291737355 0.347664681027323 no 1172 0.329894937924151 1632 2802138 YIL048W NEO1 SGTC_917 harmaline 728.087 nM 0.439214134123537 0.347988721364841 no 1173 0.33025319228654 1624 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1074 carmofur 3.8 µM 0.438405496099002 0.348253707395046 no 1174 0.33054618150144 1581 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1563 conessine 56.1 µM 0.438382954635842 0.348261095164971 no 1175 0.330554350310586 1619 441082 An anti-amoebic, histamine inhibitor. SGTC_181 1447-1644 8.07 µM 0.437622920413927 0.34851022350094 no 1176 0.330829826616735 1641 534600 SGTC_1531 st059297 52.4 µM 0.435856238833038 0.349089568799301 no 1177 0.331470518643626 1585 7566702 SGTC_65 0798-0905 34.986 µM 0.434924843066402 0.349395141803056 no 1178 0.331808490714427 1769 3602145 SGTC_1121 fusaric acid 630.51 nM 0.433061908864699 0.350006627400406 no 1179 0.332484897247621 1556 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3085 9117376 49.47 µM 0.431812560687673 0.350416928930776 no 1180 0.332938824827132 1622 16480349 SGTC_975 1335-0046 28.5 µM 0.429912097074396 0.351041399587931 no 1181 0.333629792689212 1506 16486740 SGTC_543 3844-1095 191 µM 0.429054486472103 0.351323332548636 no 1182 0.333941786592176 1666 4230703 SGTC_681 1642-0006 26.6 µM 0.428179604027903 0.351611027817495 no 1183 0.334260182207487 1550 4446530 SGTC_556 4058-0063 51.5 µM 0.422474110932645 0.353489293499153 no 1184 0.33633949676482 1615 6615692 SGTC_472 calcifediol 10 µM 0.421904720586236 0.353676935372085 no 1185 0.33654728214585 1610 5283731 A vitamin D metabolite. SGTC_2719 novobiocin 32.65 µM 0.421898655429213 0.353678934328433 no 1186 0.336549495748577 1683 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1650 st011916 45.8 µM 0.421824334250103 0.3537034294535 no 1187 0.336576621238297 1677 242528 SGTC_328 k915-0120 63.5 µM 0.420609548481316 0.35410389007974 no 1188 0.337020110051977 1683 6624543 SGTC_900 1112-0045 141 µM 0.42000162821654 0.354304354877287 no 1189 0.337242132121728 1538 56211 YIL048W NEO1 SGTC_1698 5-fluorocytosine 1.055 µM 0.419898088270761 0.354338501726229 no 1190 0.33727995219545 1699 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1057 3448-5381 134 µM 0.419854365422637 0.354352921609214 no 1191 0.337295923349921 1695 5497911 SGTC_16 erodoxin 22.806 µM 0.419600534569665 0.354436639657609 no 1192 0.337388648895802 1602 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3026 9090633 49.47 µM 0.419102601976443 0.354600887343914 no 1193 0.33757057458494 1571 25236842 SGTC_2286 7945697 125 µM 0.417120397537189 0.355255003663813 no 1194 0.338295172989123 1523 1245733 SGTC_3063 1327-0034 4 µM 0.41444657641602 0.356138025353055 no 1195 0.33927354221094 1606 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1539 benzyladenosine 56 µM 0.410417207201486 0.357470170200081 no 1196 0.340749962912826 1585 92208 A nucleotide analog. SGTC_3187 9109394 49.47 µM 0.410255070923155 0.357523810370834 no 1197 0.340809423327898 1554 17098090 SGTC_2499 avocadenofuran 51.48 µM 0.409936321515558 0.357629271672715 no 1198 0.340926330177587 1538 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1617 st002906 78 µM 0.409595096886792 0.357742181165144 no 1199 0.341051497133114 1598 5150859 SGTC_412 gemfibrozil 100 µM 0.409085166277883 0.357910937808384 no 1200 0.341238580895098 1638 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2881 9058953 51.95 µM 0.408858384194466 0.357985998087423 no 1201 0.341321795434084 1530 17122249 SGTC_1364 1653-0028 37.6 µM 0.408242243229086 0.358189955989569 no 1202 0.341547918762516 1623 5718652 SGTC_2917 7979103 53.79 µM 0.404934444376391 0.359285609845148 no 1203 0.342762849433929 1711 2980565 SGTC_642 0335-0876 158 µM 0.403556098970464 0.359742506423461 no 1204 0.343269587055693 1634 6812350 SGTC_1842 st055362 61.2 µM 0.402818834155808 0.359986978736908 no 1205 0.343540752335404 1680 676032 SGTC_1681 tripelennamine 100 µM 0.401619169570548 0.360384902270087 no 1206 0.343982159903007 1570 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2969 9091408 28.7 µM 0.401315962204125 0.360485498801948 no 1207 0.344093756472417 1549 4286311 SGTC_1863 st057641 20.1 µM 0.401060841780713 0.36057014878464 no 1208 0.344187664988943 1668 3921635 SGTC_1804 st050076 49.1 µM 0.400113769472599 0.360884450924312 no 1209 0.344536361443456 1654 3895976 SGTC_2612 dictamnine 15.46 µM 0.399701164000853 0.36102141050616 no 1210 0.344688317341156 1630 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1947 st076332 61.6 µM 0.397793736211264 0.361654790317158 no 1211 0.345391117428937 1675 24208416 SGTC_2947 9072639 7.68 µM 0.397665568020939 0.361697363418271 no 1212 0.345438360708693 1558 16488146 SGTC_1926 methyl fluorone black 53.6 µM 0.396929690906127 0.361941829812476 no 1213 0.345709654378296 1551 72721 Reacts with homocysteine. SGTC_1764 st044502 93.5 µM 0.396807930808007 0.361982285278568 no 1214 0.345754550963555 1608 8407 SGTC_2462 5162487 171.77 µM 0.394616885501145 0.362710535357644 no 1215 0.346562825004908 1687 2259986 SGTC_385 1494-0393 12.4 µM 0.393738398741419 0.363002662658852 no 1216 0.346887094280756 1665 3090647 SGTC_1621 st003705 32.4 µM 0.392358009046439 0.363461851102179 no 1217 0.347396853798323 1737 24207032 SGTC_1493 4348-0038 111 µM 0.391711697605569 0.363676914946497 no 1218 0.347635622971627 1687 800424 SGTC_2206 7254556 146.969 µM 0.39124058027289 0.363833709021077 no 1219 0.347809707652454 1709 4398905 SGTC_1765 st044815 90.4 µM 0.390447262860241 0.364097787058774 no 1220 0.348102922429742 1564 645695 SGTC_397 arbidol 50 µM 0.389867756521698 0.364290732863439 no 1221 0.348317168799723 1733 131410 A RNA synthesis inhibitor. SGTC_215 1287-0124 461.5 µM 0.388974108049769 0.36458833924713 no 1222 0.348647649941183 1757 5560863 SGTC_785 1270-0111 65.3 µM 0.387401201041039 0.365112353213391 no 1223 0.349229607391617 1624 6741994 SGTC_2704 st078022 71.1 µM 0.38692149372523 0.365272217893842 no 1224 0.349407164210377 1785 54697681 SGTC_2158 5657123 3.6195 µM 0.386694144621024 0.365347991213256 no 1225 0.349491325751495 1667 2858827 SGTC_2353 9059630 146.67 µM 0.385523755278339 0.365738154102462 no 1226 0.3499247049542 1715 4779114 SGTC_635 k038-0028 24.7 µM 0.38189870808933 0.366947485640189 no 1227 0.351268249293142 1703 4035102 SGTC_905 2-aminofluorene 215 µM 0.38163662324658 0.367034969654484 no 1228 0.351365457629006 1633 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1500 4488-1866 171 µM 0.379736147148132 0.367669555569748 no 1229 0.352070642493847 1751 2900003 SGTC_1260 0700-1617 7.75 µM 0.379376311424844 0.367789748675967 no 1230 0.352204219428273 1683 2853078 SGTC_748 act1.228 77.9 µM 0.379295769978684 0.367816653077752 no 1231 0.352234120235026 1589 4421505 YNR035C ARC35 SGTC_1172 0370-0043 85 µM 0.378036763091016 0.368237301240457 no 1232 0.352701641972206 1701 376585 SGTC_2217 6934799 96.0675 µM 0.375997695017036 0.368918911494433 no 1233 0.35345930480772 1730 675606 SGTC_2755 lomerizine 42.69 µM 0.371400682130441 0.370457089988058 no 1234 0.355169558790713 1620 3949 A calcium channel blocker. SGTC_2046 4110841 106 µM 0.369759813043042 0.37100663463279 no 1235 0.355780730421917 1752 44119630 YMR134W ERG29 SGTC_2630 antimycin a 100 µM 0.368891034344473 0.371297704563896 no 1236 0.35610447317744 1599 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_421 streptovitacin 30 mM 0.368210920978255 0.371525616684555 no 1237 0.356357983879128 1664 91467 include heat shock SGTC_1503 4585-0012 61.3 µM 0.366884590649822 0.371970211454875 no 1238 0.356852553030947 1741 2922052 SGTC_1561 5-methoxyflavone 52.9 µM 0.365398551559409 0.37246854449884 no 1239 0.357406961150152 1741 94525 SGTC_3256 9138902 49.47 µM 0.364568321582556 0.372747049497457 no 1240 0.357716832660985 1749 17228773 SGTC_3180 9109287 49.47 µM 0.364432855873676 0.372792498497408 no 1241 0.357767402213379 1692 18891271 SGTC_2601 securinine 100 µM 0.363109619426983 0.373236539854804 no 1242 0.358261499539918 1637 442872 A GABA receptor antagonist. SGTC_1987 st072290 61.9 µM 0.362461456206687 0.373454106896319 no 1243 0.358503610788686 1698 54697379 SGTC_3323 9138564 53.9225 µM 0.362367973465201 0.37348548930377 no 1244 0.358538534502939 1807 43912313 YNL103W MET4 SGTC_33 0986-0033 35.816 µM 0.36137771568163 0.373817972983489 no 1245 0.358908552168829 1700 2848082 SGTC_3228 9131799 49.47 µM 0.360842480528915 0.37399771980395 no 1246 0.359108602180381 1702 17015818 SGTC_722 3534-0461 190 µM 0.359424648101849 0.374473999625998 no 1247 0.359638719227816 1660 658262 SGTC_1669 st015249 58.4 µM 0.35915195284481 0.374565625706569 no 1248 0.359740708977993 1817 722793 SGTC_1131 3454-3128 32.3 µM 0.357641901345453 0.375073133714722 no 1249 0.3603056584178 1783 710982 SGTC_34 0469-0683 81.75 µM 0.357243771534984 0.375206975870385 no 1250 0.360454659993259 1762 3690923 SGTC_316 k060-0003 58.6 µM 0.354237265270974 0.376218178782642 no 1251 0.361580539117882 1766 6152314 SGTC_191 3914-0123 66.505 µM 0.353686769818564 0.376403423737498 no 1252 0.361786819350345 1655 3144412 SGTC_1142 3253-1408 9.78 µM 0.352281228092281 0.376876525846588 no 1253 0.362313682386195 1796 256655 SGTC_2583 asiatic acid 100 µM 0.351435604996727 0.377161249782949 no 1254 0.362630787406976 1730 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1953 st076800 12.1 µM 0.351408676435012 0.377170317811991 no 1255 0.362640887051255 1637 297591 SGTC_1816 st051957 91.6 µM 0.351408569858271 0.377170353701194 no 1256 0.362640927023397 1702 674121 SGTC_1892 st058411 7.36 µM 0.351382026327637 0.37717929213992 no 1257 0.362650882354428 1785 3934738 SGTC_1515 3460-0031 42.1 µM 0.35027348118226 0.377552649451329 no 1258 0.363066732563165 1735 2876596 SGTC_210 3551-0445 56.827 µM 0.34831006369541 0.378214207910808 no 1259 0.363803668382149 1743 2865180 YOR207C RET1 SGTC_258 haloperidol 50.781 µM 0.347783366873844 0.378391735208457 no 1260 0.364001441062177 1660 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1644 st010134 20.9 µM 0.347623969863042 0.378445466283917 no 1261 0.364061301185268 1798 3818134 SGTC_1972 st070201 17.4 µM 0.346504619831355 0.378822853693275 no 1262 0.364481756444795 1820 2829099 SGTC_1729 st035615 45.989 µM 0.346230750793136 0.378915205893497 no 1263 0.364584653210073 1690 17385451 SGTC_62 0180-0423 3.232 µM 0.342733406865089 0.380095161863251 no 1264 0.365899514094884 1775 30102 YGL099W LSG1 SGTC_1085 doxorubicin 7.67 µM 0.341171004928655 0.380622656503568 no 1265 0.366487424956418 1814 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2386 9075165 157.42 µM 0.340784611375643 0.380753144109012 no 1266 0.366632868056575 1729 16452277 SGTC_68 0986-0284 82.829 µM 0.337823990615594 0.381753414074069 no 1267 0.367747914884163 1602 423278 YIL048W NEO1 SGTC_307 1501-1223 22.3 µM 0.337806686554722 0.381759262721473 no 1268 0.367754435332075 1726 2830329 SGTC_1060 3448-7350 82 µM 0.337483100237418 0.38186863752639 no 1269 0.367876374869555 1825 570178 SGTC_2759 disulfiram 3.38 µM 0.337396257885948 0.381897992552336 no 1270 0.367909102612321 1681 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2693 st077581 40.7 µM 0.336925667136696 0.38205707655572 no 1271 0.368086467925173 1752 25238761 SGTC_530 4358-1714 28 µM 0.335590359629393 0.382508587876367 no 1272 0.368589897364503 1779 1564641 SGTC_861 0443-0273 110 µM 0.335320790305175 0.382599757519502 no 1273 0.368691556136527 1776 6149169 SGTC_2502 avocadyne acetate 18.59 µM 0.334327258951309 0.382935830753942 no 1274 0.369066311514248 1688 3952079 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.334166424771637 0.382990243033178 no 1275 0.369126989131393 1844 688798 SGTC_911 3456-4043 236 µM 0.333581252920063 0.383188233700605 no 1276 0.369347783354688 1797 914281 SGTC_3027 9089541 49.47 µM 0.332605022759785 0.383518605356085 no 1277 0.369716225718129 1718 9943819 SGTC_2434 5670830 169.91 µM 0.332267890955024 0.38363271575569 no 1278 0.369843491596633 1730 1549830 SGTC_2062 5245942 200 µM 0.331107015318905 0.384025719300294 no 1279 0.370281826392097 1751 1376160 SGTC_1978 st071761 42 µM 0.330845389662886 0.384114306694662 no 1280 0.370380636857985 1691 5147680 SGTC_2597 laccaic acid a 100 µM 0.330702799532537 0.384162590778531 no 1281 0.370434493729956 1736 5491415 A textile dye. SGTC_877 0771-0151 33.1 µM 0.328108236607229 0.38504147883705 no 1282 0.371414913259013 1761 6166523 SGTC_2985 9022375 71.43 µM 0.326865443549825 0.385462674942093 no 1283 0.371884829367118 1738 4939335 SGTC_1094 duloxetine 25.4 µM 0.3256573385197 0.385872244424364 no 1284 0.372341812501435 1760 60834 A selective serotonin reuptake inhibitor. SGTC_2729 fluphenazine 10.66 µM 0.324164709738418 0.386378448310405 no 1285 0.372906669118664 1686 3372 An atypical antipsychotic. SGTC_3350 9150499 3.57 µM 0.322844801250394 0.386826237751191 no 1286 0.373406390859065 1737 4910996 YPR165W RHO1 SGTC_1268 0828-0275 2.46 µM 0.319158689255465 0.388077576887756 no 1287 0.374803090621744 1807 745337 SGTC_2214 7179297 48.276 µM 0.318430426038115 0.388324941294364 no 1288 0.375079230904402 1815 769744 SGTC_247 mechlorethamine 29.705 µM 0.318328321984818 0.388359625934212 no 1289 0.375117951481906 1774 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_902 1120-0002 2.07 µM 0.316252357436746 0.389065021620273 no 1290 0.375905484968592 1716 3280475 SGTC_1441 4106-0040 13 µM 0.314474246361025 0.38966950010164 no 1291 0.376580436733197 1760 2904180 SGTC_783 0848-0141 92.7 µM 0.313041958591411 0.390156608308408 no 1292 0.377124392319156 1742 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_630 4356-0227 183 µM 0.311461466963601 0.390694319513665 no 1293 0.377724915979165 1766 779312 SGTC_1721 st082152 9.2685 µM 0.311424100890085 0.39070703464683 no 1294 0.37773911717721 1734 5296051 SGTC_584 0986-0246 15.4 µM 0.311318762188304 0.390742880509136 no 1295 0.377779152665662 1825 53315 YDR232W HEM1 SGTC_1240 0356-0016 42.1 µM 0.3108813901906 0.390891724399261 no 1296 0.37794539622155 1798 4305613 SGTC_629 3448-6466 76.7 µM 0.308666193095093 0.39164583245488 no 1297 0.378787731427333 1768 573744 SGTC_1032 k061-1018 98.7 µM 0.307955311605719 0.391887920624906 no 1298 0.379058168495727 1914 4005393 SGTC_3311 9131146 2.8755 µM 0.307927873244363 0.391897265501252 no 1299 0.379068607921082 1766 4900406 YPR165W RHO1 SGTC_1846 st056244 14.8 µM 0.307244837217298 0.392129911987061 no 1300 0.379328509852415 1805 5393182 SGTC_2773 thioridazine 9.09 µM 0.307172084368831 0.392154694351647 no 1301 0.379356196243803 1807 5452 An antipsychotic. SGTC_2328 6201408 200 µM 0.307056344094212 0.392194120756667 no 1302 0.379400242949536 1739 2890418 SGTC_1479 0549-0158 134 µM 0.306999861784708 0.392213361603735 no 1303 0.379421738712015 1754 5440202 SGTC_106 0092-0003 11.579 µM 0.304359612761518 0.39311306268801 no 1304 0.380426966722885 1891 1072148 SGTC_1888 azatryptophan 97.5 µM 0.304198057251718 0.393168133538848 no 1305 0.380488502420697 1751 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_518 1021-0119 62.6 µM 0.303976150672595 0.393243780275555 no 1306 0.380573030473075 1714 1097762 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.303124931261462 0.393533993670699 no 1307 0.380897327516566 1717 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_462 ag-879 158 µM 0.302543883716832 0.393732129080971 no 1308 0.381118742722946 1883 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2356 9061756 188.97 µM 0.300994397222757 0.394260633563208 no 1309 0.381709383452342 1904 20104043 SGTC_2395 5646831 180.19 µM 0.300096132418629 0.394567106220762 no 1310 0.382051914606649 1831 6808628 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.300018636713142 0.394593549497048 no 1311 0.382081470015605 1854 688761 SGTC_1484 3473-2379 286 µM 0.299682749475754 0.394708167384003 no 1312 0.382209579051478 1820 671917 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.29730596925313 0.395519477823125 no 1313 0.383116462386213 1801 364106 SGTC_440 fluspirilene 35.1 µM 0.29592742427462 0.395990249926852 no 1314 0.383642753506733 1860 3396 An atypical antipsychotic. SGTC_932 2857-0803 154 µM 0.294132811306738 0.396603336210697 no 1315 0.38432820971906 1893 674898 SGTC_228 caffeine 993.056 µM 0.292208617046091 0.397260974879275 no 1316 0.385063561784522 1882 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2293 7624732 200 µM 0.291903328840655 0.397365341212261 no 1317 0.385180269118715 1733 894453 SGTC_644 1498-1197 63.3 µM 0.291507131173843 0.39750079696042 no 1318 0.385331745351834 1854 6741615 SGTC_3263 9137018 49.47 µM 0.291355151152276 0.397552760586738 no 1319 0.385389855742332 1687 43844957 SGTC_2223 6903751 107.57 µM 0.290537331558718 0.397832413212788 no 1320 0.385702597673725 1859 5598863 SGTC_2673 kobusone 100 µM 0.290019463121318 0.398009524988227 no 1321 0.385900673894639 1838 6710676 An epoxy ketone and protein crosslinker. SGTC_1212 0520-0165 585 µM 0.28993145076834 0.398039627434391 no 1322 0.385934340141649 1949 5403258 SGTC_2587 piperic acid 92.2 µM 0.289443161806128 0.39820664560345 no 1323 0.386121134711542 1762 5370536 SGTC_3165 9101544 49.47 µM 0.288440087689927 0.398549803387366 no 1324 0.386504942730471 1875 5002184 SGTC_2333 9017922 200 µM 0.287662900644094 0.398815737782321 no 1325 0.386802395561632 1907 3163164 SGTC_3070 9117005 49.47 µM 0.28557994432284 0.399528705851898 no 1326 0.387599933059515 1872 8779016 SGTC_703 3875-0075 71.8 µM 0.285466910060361 0.399567405576237 no 1327 0.3876432260454 1826 2850814 SGTC_662 k832-1615 104 µM 0.2852966328056 0.399625705539713 no 1328 0.387708446171699 1852 5878478 SGTC_3257 9139206 32.98 µM 0.285034802021034 0.399715356201724 no 1329 0.387808739598321 1901 4910041 SGTC_407 eburnamonine 100 µM 0.28454621011431 0.399882663834822 no 1330 0.387995913143572 1768 3195 SGTC_2511 berberine 10.47 µM 0.284438879839803 0.399919419207902 no 1331 0.388037033538293 1778 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1068 loratadine 26.9 µM 0.284415740296031 0.399927343486862 no 1332 0.38804589892912 1778 3957 A H1 histamine antagonist. SGTC_2887 9044784 58.44 µM 0.282609864113733 0.400545903743935 no 1333 0.388737959000271 1880 6465546 SGTC_2287 7945887 168.79 µM 0.281892994639964 0.400791519726827 no 1334 0.389012780636435 1944 1245853 SGTC_1772 st048439 82.2 µM 0.281640313684115 0.400878103393332 no 1335 0.389109662553735 1809 2927068 YDL195W SEC31 SGTC_2174 5790901 200 µM 0.281266966592188 0.40100604343441 no 1336 0.389252822414598 1803 786020 SGTC_914 3820-6779 408 µM 0.278557286879075 0.40193492442262 no 1337 0.390292297880644 1770 2893481 SGTC_3175 9106517 49.47 µM 0.278504163803916 0.401953140623373 no 1338 0.39031268458984 1797 41468073 SGTC_1699 st031318 29.054 µM 0.278129291897091 0.402081692357587 no 1339 0.390456555400213 1888 5340658 SGTC_1999 st074831 12.5 µM 0.27731726180643 0.402360191453404 no 1340 0.390768253075673 1785 17112523 SGTC_1342 1486-1464 234 µM 0.27546155927866 0.40299682106083 no 1341 0.391480827531191 1812 3253938 SGTC_234 nsc-17383 10.7 µM 0.274180856180005 0.403436337686962 no 1342 0.391972819581 1919 408974 SGTC_1710 st031758 61.5 µM 0.273933219930206 0.403521336541554 no 1343 0.3920679709298 1925 5394341 SGTC_1353 1498-1206 8.11 µM 0.272888851031142 0.403879856609689 no 1344 0.392469328483531 1813 6756808 SGTC_1924 st058459 75.1 µM 0.272463002915829 0.404026068664266 no 1345 0.392633017457188 1856 688683 SGTC_1883 5-benzylidenerhodanine 20 µM 0.271023019861018 0.404520576273417 no 1346 0.393186663671078 1952 1273210 SGTC_2472 5377652 49.4 µM 0.268643457913772 0.405338080653081 no 1347 0.394102033303522 1809 1610903 SGTC_512 prima-1 270 µM 0.265986229789775 0.406251466104551 no 1348 0.395124907088044 1914 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2546 rhodinyl acetate 100 µM 0.265938551681501 0.40626785947158 no 1349 0.395143266930725 1965 6708682 SGTC_1024 4507-0395 26 µM 0.265298155026095 0.406488065695514 no 1350 0.395389892840821 1842 4201836 SGTC_2332 7982454 138.89 µM 0.264109873227515 0.406896745524651 no 1351 0.395847628100121 1878 2981748 SGTC_2373 9071805 200 µM 0.26114711999745 0.407916151149653 no 1352 0.396989527760114 2008 10149009 SGTC_439 amiodarone 34.4 µM 0.260842075780131 0.408021144388502 no 1353 0.397107147763055 1900 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1395 3486-0190 4.35 µM 0.260087397538684 0.408280925633375 no 1354 0.397398179404078 1975 6748079 SGTC_3050 9093513 49.47 µM 0.260014690626102 0.408305955506254 no 1355 0.39742622087889 1831 25236664 SGTC_391 gliotoxin 8.33 µM 0.259197402772106 0.40858733839063 no 1356 0.397741467467756 1897 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1129 3453-1384 223 µM 0.258648791044844 0.408776245595627 no 1357 0.397953117014413 1875 1084452 SGTC_2922 7999257 32.47 µM 0.258536712664902 0.40881484091466 no 1358 0.397996359557663 1842 2988377 SGTC_1440 4100-1550 40 µM 0.258261077903909 0.408909762281449 no 1359 0.398102711428084 1939 742806 SGTC_2671 danthron 100 µM 0.257650920181288 0.409119903559083 no 1360 0.398338163714863 1845 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1637 st007924 17.4 µM 0.25681496978014 0.409407851328295 no 1361 0.398660806675938 1826 683336 SGTC_2459 5811157 9.22 µM 0.256013754652366 0.40968388021885 no 1362 0.398970108248593 1974 2870684 YBR192W RIM2 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.254568305658682 0.410181969097679 no 1363 0.399528270618154 1821 2333 A French combination drug. SGTC_875 0709-0210 25.7 µM 0.25337248327104 0.410594148458045 no 1364 0.399990194605776 2012 6251364 SGTC_3066 9117245 49.47 µM 0.25248127033989 0.410901398446157 no 1365 0.400334544685048 1925 17176980 SGTC_1104 tacrolimus 29.8 µM 0.252383561592662 0.410935087340528 no 1366 0.400372302462914 1886 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_372 0155-0182 15.9 µM 0.252161375072327 0.411011697238129 no 1367 0.400458165889976 1911 771486 SGTC_3056 9094900 49.47 µM 0.251760993214641 0.411149757443534 no 1368 0.400612904603814 1768 25236784 SGTC_2900 5328528 85.29 µM 0.248296721877944 0.412344769902977 no 1369 0.401952417585358 1840 795359 SGTC_574 1315-0397 40 µM 0.246675839660186 0.412904178772292 no 1370 0.402579553002306 1904 6794277 SGTC_1874 staurosporine 7.6 µM 0.244839437969946 0.413538182766703 no 1371 0.40329037799643 1952 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_867 0518-0118 155 µM 0.244228586607505 0.413749124705166 no 1372 0.403526894188463 2028 6848158 SGTC_1447 4239-0816 81.9 µM 0.243587903694087 0.413970394952899 no 1373 0.403774998804074 1791 1341554 SGTC_3313 9133968 57.047 µM 0.242789625272916 0.414246131579641 no 1374 0.404084186489756 1896 1494643 SGTC_1299 1079-1439 3.74 µM 0.241466937181429 0.414703099690632 no 1375 0.404596619363152 1848 323161 SGTC_1730 st033808 45.1 µM 0.241384699973767 0.414731515182175 no 1376 0.404628484932662 1848 1045166 SGTC_1871 st057448 67.3 µM 0.240703966500727 0.414966746711042 no 1377 0.404892282262153 1945 691747 SGTC_2007 4011539 71.82 µM 0.239640102562006 0.415334432296815 no 1378 0.405304636550852 1837 45595301 SGTC_2378 9074213 121.43 µM 0.238278488288506 0.415805132527314 no 1379 0.405832552382992 1875 657714 SGTC_347 4534-1311 26.2 µM 0.23626888777331 0.416500057488702 no 1380 0.406612013760212 1876 2862016 SGTC_2000 st075254 36.4 µM 0.235092994282786 0.416906805656497 no 1381 0.407068278045431 1880 17234175 SGTC_683 panaxydol 45 µM 0.228429446235346 0.419213432506208 no 1382 0.40965619986406 1982 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2212 7123476 200 µM 0.227983831814813 0.419367784615081 no 1383 0.409829404952392 1979 1085715 SGTC_2114 5491910 81.25 µM 0.225944436515777 0.420074349206178 no 1384 0.410622317998799 1975 2849228 SGTC_3201 9113999 49.47 µM 0.225694213508491 0.420161058734119 no 1385 0.410719629465378 1940 16649224 SGTC_2016 5121758 140 µM 0.225074727822483 0.420375745152381 no 1386 0.410960570435659 1969 2795203 SGTC_1233 0325-0408 14.2 µM 0.224205020649891 0.420677187264159 no 1387 0.411298888500109 1973 12874 SGTC_580 1123-0028 41 µM 0.223984270697047 0.420753707014692 no 1388 0.411384771240808 1980 1677248 YPR107C YTH1 SGTC_2935 9038016 29.96 µM 0.223362772907907 0.420969156228866 no 1389 0.411626587670417 2032 6463195 SGTC_1235 benzylparaben 21.5 µM 0.221447490800601 0.421633258962982 no 1390 0.412372008928345 1934 7180 SGTC_2838 9002687 71.43 µM 0.220142738615803 0.422085795042544 no 1391 0.412879995271162 1831 6457060 SGTC_2104 5389443 200 µM 0.21990482934008 0.422168321843956 no 1392 0.412972637552406 1991 2244536 SGTC_1839 st053978 48 µM 0.218226525500521 0.422750594632615 no 1393 0.413626309366786 2037 3788398 SGTC_834 0312-0008 75.7 µM 0.21811780346802 0.422788320623614 no 1394 0.413668663092184 1905 6385573 YIL048W NEO1 SGTC_167 3672-0051 66.205 µM 0.21656830635707 0.423326065025149 no 1395 0.414272393698523 1910 3237971 SGTC_1986 st071812 45 µM 0.215650873915644 0.423644522276139 no 1396 0.414629948520935 1949 11838594 SGTC_199 4063-0024 41.6 µM 0.214909893900929 0.423901766147135 no 1397 0.414918785452253 2008 306215 SGTC_2361 9034121 116 µM 0.214903690340045 0.42390391995632 no 1398 0.414921203819124 1910 6496917 SGTC_3203 9113543 49.47 µM 0.213763167197154 0.424299935805126 no 1399 0.41536587466627 1937 17018012 SGTC_2087 5276107 200 µM 0.212312082081039 0.424803896355798 no 1400 0.415931785076444 1937 144405 SGTC_2822 7994718 71.43 µM 0.210747998520318 0.425347238809189 no 1401 0.416541959122393 1993 1018011 SGTC_1147 3809-1045 12.3 µM 0.210656259501587 0.425379112173825 no 1402 0.416577754242197 1907 325925 SGTC_387 norethindrone acetate 66.7 µM 0.210540089806411 0.425419474315275 no 1403 0.416623082819642 1894 541197 SGTC_442 cape 100 µM 0.210242462343429 0.425522885931743 no 1404 0.416739219967165 2045 5281787 SGTC_2918 7977171 22.06 µM 0.2092324232814 0.425873865398291 no 1405 0.417133401210923 1923 2236483 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.207398598735414 0.426511252829119 no 1406 0.417849288428734 1834 5711223 A potent inhibitor of glutathione S-transferases. SGTC_796 1234-0020 70.7 µM 0.20735081445851 0.426527863914945 no 1407 0.417867946073751 2015 46495034 SGTC_1025 k007-0731 70 µM 0.207067330503703 0.426626413158021 no 1408 0.417978637810169 1849 6256118 SGTC_93 0109-0045 59.227 µM 0.206819932575522 0.42671242134074 no 1409 0.418075244376813 2062 88733 SGTC_3330 9141424 71.43 µM 0.206789332142474 0.426723059859786 no 1410 0.418087193902063 2031 27261020 SGTC_3280 9140961 49.47 µM 0.206741174023594 0.426739802576063 no 1411 0.418105999888981 1890 4901226 SGTC_1089 terbinafine 2.25 µM 0.206261913090422 0.426906430264212 no 1412 0.418293163883512 2050 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2865 9030313 51.95 µM 0.205083760777352 0.427316101336716 no 1413 0.41875334190017 1861 42562754 SGTC_984 1492-0255 2.91 µM 0.204747632157641 0.427432995499772 no 1414 0.418884651793095 1948 1585198 SGTC_2229 7354935 190 µM 0.203055126611241 0.428021688274158 no 1415 0.419545972395086 2035 318112 SGTC_2543 pimpinellin 60.67 µM 0.201888425079475 0.428427587573621 no 1416 0.420001975603338 1892 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_254 nsc-64875 3.808 µM 0.201504037786825 0.428561333782274 no 1417 0.420152236244647 2047 56993 SGTC_1812 st052057 4.327 µM 0.201451006763211 0.428579786385137 no 1418 0.420172967489267 1947 3645418 SGTC_2189 6047310 154.431 µM 0.201377131962949 0.428605492020414 no 1419 0.420201847492469 1944 711535 SGTC_677 0929-0063 136 µM 0.201166641578246 0.428678736370533 no 1420 0.420284137217532 2014 1539583 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.199846477751767 0.429138169764136 no 1421 0.420800325235857 2032 66535 A nucleotide analog. SGTC_3034 9090421 49.47 µM 0.199764594673222 0.429166669260305 no 1422 0.420832346260229 2050 17173761 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.199346023329258 0.429312359245111 no 1423 0.420996040066848 2027 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_92 0063-0024 660.874 µM 0.198512081010555 0.429602653963441 no 1424 0.421322216777854 2084 3594437 SGTC_2161 5662504 8.5105 µM 0.197726643078404 0.429876099155126 no 1425 0.421629471537324 1937 2859334 SGTC_2319 6033012 152.6 µM 0.196809305701219 0.430195506875669 no 1426 0.421988384323984 1920 847246 SGTC_433 pimozide 108 µM 0.196324405094326 0.430364362897805 no 1427 0.422178130284719 1803 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_17 0960-0276 49.807 µM 0.192904622217716 0.431555587298794 no 1428 0.423516832510147 2032 6821114 SGTC_1663 st014140 55.4 µM 0.19258135052936 0.431668225990755 no 1429 0.423643425817435 2071 4207120 SGTC_560 2332-1943 155 µM 0.191628078988875 0.432000410063139 no 1430 0.424016773128392 1993 21177716 SGTC_209 4077-0173 175.592 µM 0.191277279776318 0.432122664274199 no 1431 0.424154180278 2002 15993494 SGTC_3015 9080845 49.47 µM 0.189825493498082 0.432628683615362 no 1432 0.424722939087822 2062 5296973 SGTC_224 benfluorex 43.875 µM 0.189528060412788 0.432732367426925 no 1433 0.424839482297142 2065 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3310 9130229 44.1445 µM 0.188046270269391 0.433248981562033 no 1434 0.425420189847147 2048 7761258 SGTC_2903 5923464 63.88 µM 0.187241915260626 0.433529461252217 no 1435 0.425735481159609 2102 2876576 SGTC_2049 5262831 67.185 µM 0.187200773454859 0.43354380835726 no 1436 0.425751609215016 1963 763417 SGTC_49 0717-0965 32.132 µM 0.186971351237325 0.433623814828353 no 1437 0.425841547608397 2042 5889349 YGL099W LSG1 SGTC_1318 1280-3875 124 µM 0.185041481627881 0.434296926123888 no 1438 0.426598249855456 2014 373245 SGTC_3108 9121785 49.47 µM 0.184072288995554 0.43463503883476 no 1439 0.426978372593011 2101 17140271 SGTC_1477 0139-0234 16 µM 0.183534632014305 0.434822626577911 no 1440 0.42718927391897 2067 620880 SGTC_612 0302-0167 22.4 µM 0.183171493066723 0.434949333535858 no 1441 0.427331730580729 2049 235821 SGTC_1554 st069299 38.7 µM 0.183011335379828 0.435005218107405 no 1442 0.427394562241936 2024 24207999 SGTC_2999 9069765 71.4286 µM 0.182882081558654 0.435050320195197 no 1443 0.427445271312147 2024 2097066 SGTC_2452 5863136 48.41 µM 0.181987653662921 0.435362446786685 no 1444 0.427796207527865 2013 2184096 SGTC_3189 9110682 49.47 µM 0.180001145379479 0.436055818121499 no 1445 0.42857583450164 1952 17122418 SGTC_121 0557-0495 61.343 µM 0.179770003928136 0.436136508597206 no 1446 0.428666566666308 2033 3104427 SGTC_2326 6164455 177.58 µM 0.179269167340188 0.436311357587811 no 1447 0.42886317777143 1958 2888790 SGTC_3025 9087895 49.47 µM 0.179256753333893 0.436315691647584 no 1448 0.428868051304924 2095 17173641 SGTC_3356 9151811 4.48 µM 0.178447475395011 0.436598248573326 no 1449 0.429185783799773 1961 1859254 YPR165W RHO1 SGTC_844 0330-0132 15.3 µM 0.17826651531309 0.436661434665395 no 1450 0.429256837243444 2076 2828079 SGTC_1709 st033179 39.1045 µM 0.17705599278248 0.437084156044839 no 1451 0.429732204195259 2068 573381 SGTC_2070 5230947 200 µM 0.175982761949195 0.43745899447706 no 1452 0.430153742530714 2106 2835538 SGTC_2871 9038510 12.99 µM 0.175473035010134 0.437637042261357 no 1453 0.430353978492065 2121 4945164 SGTC_348 k064-0012 10.7 µM 0.173709178094555 0.438253255283009 no 1454 0.431047012057875 2007 5066323 SGTC_343 4130-2827 29.8 µM 0.17227351561774 0.438754922399909 no 1455 0.431611252264117 1948 1118244 SGTC_2594 a-mangostin 100 µM 0.17200189537956 0.438849846431436 no 1456 0.43171801945486 2084 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3114 9122766 49.47 µM 0.17145541844056 0.439040836203085 no 1457 0.431932841115393 1965 17176985 SGTC_589 1227-0070 34.1 µM 0.170964613867124 0.439212380981433 no 1458 0.432125794967751 2026 2841384 SGTC_600 1495-0418 41.6 µM 0.170829489456839 0.439259611330631 no 1459 0.432178920331627 2014 5377768 SGTC_2272 7805186 180 µM 0.169798953162748 0.439619845473758 no 1460 0.43258412511466 2141 2956062 YPR165W RHO1 SGTC_36 0335-0881 14.2 µM 0.169157917082928 0.439843951212742 no 1461 0.432836215002651 2015 23828853 SGTC_2394 5221648 200 µM 0.168108660566624 0.440210812080668 no 1462 0.433248898084383 2059 788586 SGTC_3035 9091303 49.47 µM 0.167771705509077 0.440328635572703 no 1463 0.433381441342795 2074 25237002 SGTC_983 1491-0821 12.2 µM 0.167270674749129 0.440503841385267 no 1464 0.433578538596068 2101 46495113 SGTC_626 0214-0009 33 µM 0.166359033408002 0.440822663768741 no 1465 0.433937205632062 2078 3437874 SGTC_2705 st078069 42.8 µM 0.166351163817563 0.440825416116605 no 1466 0.433940302002124 2005 1530061 SGTC_1571 st070080 73.4 µM 0.166018480406859 0.440941773002663 no 1467 0.434071203364931 2067 4315245 SGTC_575 k072-0246 11.9 µM 0.1652472002663 0.441211549828478 no 1468 0.434374707725617 2055 6796779 SGTC_2235 salicylic acid 500 µM 0.165156594288398 0.441243243599334 no 1469 0.434410364381319 2119 338 A COX inhibitor and kinase inhibitor. SGTC_3179 9107801 49.47 µM 0.164627586180211 0.441428296972158 no 1470 0.434618558418075 2029 4818259 SGTC_1443 4112-3303 14 µM 0.164382966614837 0.441513872152235 no 1471 0.434714835921354 2022 704433 SGTC_2846 9008642 19.48 µM 0.163980539968786 0.441654658868717 no 1472 0.434873231643219 1979 2992898 SGTC_1737 st035557 69.7 µM 0.163749106741496 0.441735627831697 no 1473 0.434964328838938 2090 5716916 SGTC_1546 5-methoxyflavanone 78.7 µM 0.163020881869661 0.441990419616741 no 1474 0.435250996625588 2130 147795 SGTC_428 3448-4153 16.5 µM 0.162871136710169 0.442042815527828 no 1475 0.435309948456042 1889 3834874 SGTC_2539 epi(13)torulosol 80 µM 0.162758200982364 0.442082332469964 no 1476 0.435354410062231 1972 6708597 SGTC_139 0099-0334 718.624 µM 0.162453886152164 0.442188817066668 no 1477 0.435474219671275 2155 97690 SGTC_598 3937-0236 20.2 µM 0.16182443254312 0.442409086138693 no 1478 0.435722056121339 2069 1379313 SGTC_950 1165-0508 94.1 µM 0.160899776786416 0.442732689617907 no 1479 0.436086169056526 1981 6148369 SGTC_2792 7535235 81.82 µM 0.159885985087921 0.443087532070977 no 1480 0.436485444384692 1967 1281891 SGTC_2095 5432005 200 µM 0.159503850645278 0.443221296776904 no 1481 0.436635962390695 2037 783734 SGTC_2421 5690543 90.72 µM 0.159494504727434 0.44322456836097 no 1482 0.436639643746563 2017 3397993 SGTC_2315 7733312 200 µM 0.159353206549619 0.443274030947868 no 1483 0.43669530174956 2002 726316 SGTC_2419 paclitaxel 166.5 µM 0.159296935321843 0.443293729399162 no 1484 0.436717467594327 1978 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3306 9127676 59.7925 µM 0.157690881211749 0.443856007741915 no 1485 0.437350193164016 1981 41905287 SGTC_323 4013-0906 34.3 µM 0.156851018432308 0.444150088157166 no 1486 0.437681131771729 2140 2910086 SGTC_3181 9108277 49.47 µM 0.155868949910186 0.444494001323524 no 1487 0.438068160254539 2031 17097298 SGTC_1303 1160-0052 261 µM 0.154092552952273 0.445116188455513 no 1488 0.438768380017409 2150 3562476 SGTC_386 1509-0011 3.07 µM 0.152595005659182 0.445640812965388 no 1489 0.439358831889747 2055 3107280 SGTC_850 0388-0143 75.9 µM 0.152487464013752 0.445678490897858 no 1490 0.439401238541209 2011 67273 SGTC_3319 9138450 16.7555 µM 0.149032219360445 0.446889318148221 no 1491 0.440764104740837 2006 2029690 SGTC_2325 6158266 200 µM 0.148963916059269 0.44691325881905 no 1492 0.440791053017602 2030 3623240 SGTC_2307 7538926 6.34 µM 0.147561920742822 0.447404708260391 no 1493 0.441344254437881 2020 96582 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.144243371057697 0.448568298952627 no 1494 0.442654146937274 2147 5355888 SGTC_2146 5545642 200 µM 0.143549432128513 0.448811672634953 no 1495 0.442928137131511 2138 825326 SGTC_1346 1488-2224 62.4 µM 0.142631968056481 0.44913346913509 no 1496 0.443290424371865 2165 3722427 SGTC_1941 st076221 61.8 µM 0.141842822301516 0.449410285325151 no 1497 0.443602079351263 2170 2828568 SGTC_248 streptozotocin 5.23457 mM 0.141601131076518 0.449495070595112 no 1498 0.443697536733328 2162 5300 DNA alkylating agent. SGTC_2451 5856223 45.7 µM 0.141293765448412 0.449602897772804 no 1499 0.443818937328672 2042 2179896 SGTC_2775 cyproheptadine 69.59 µM 0.1396438371228 0.450181773833651 no 1500 0.444470701463753 2171 2913 A selective serotonin reuptake inhibitor. SGTC_2772 vinpocetine 57.06 µM 0.138522984673478 0.450575084582935 no 1501 0.444913552790474 2130 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1398 3558-0053 112 µM 0.138189507487381 0.450692112192828 no 1502 0.445045323675153 2064 4532369 SGTC_2011 4012611 177 µM 0.137826876316892 0.450819375715768 no 1503 0.445188621418846 2055 2049887 SGTC_331 k048-0133 24.5 µM 0.137510102692805 0.450930549909286 no 1504 0.445313803904178 2057 6813582 SGTC_1226 3909-7979 35.4 µM 0.136360164515979 0.451334162040859 no 1505 0.445768281790716 2143 6615510 SGTC_2522 biochanin a 4.94 µM 0.135909257239735 0.451492437911018 no 1506 0.445946508582631 2137 5280373 A possible chelator. SGTC_1282 0886-0010 32.4 µM 0.134670317713044 0.451927365691274 no 1507 0.446436271196876 2164 2836211 YNL267W PIK1 SGTC_469 w7 172 µM 0.133236213232508 0.452430877841631 no 1508 0.447003286062824 2192 45115570 A P450 inhibitor. SGTC_1896 st058441 89 µM 0.131897926762582 0.452900817447848 no 1509 0.447532514253039 2023 688759 SGTC_2872 9044037 25.97 µM 0.130455814968503 0.453407289175231 no 1510 0.448102904937768 2101 6465195 SGTC_303 1348-1668 34.2 µM 0.130193359887984 0.453499471951638 no 1511 0.448206723954607 2087 5380509 SGTC_1065 prochlorperazine maleate 2.48 µM 0.129878534441274 0.453610052212056 no 1512 0.448331263728856 2176 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1049 3226-0134 66 µM 0.126974762573589 0.454630150472125 no 1513 0.449480186698213 2171 5702385 SGTC_2190 6049624 200 µM 0.126566413725523 0.454773628031147 no 1514 0.449641790536536 2159 2265554 SGTC_1483 3453-0561 55.9 µM 0.126314670158916 0.454862083658443 no 1515 0.449741422081949 2145 4546991 SGTC_2269 7935389 174.42 µM 0.125997418402476 0.454973560213098 no 1516 0.449866984053253 2126 97605 SGTC_2830 7992007 71.43 µM 0.125076823390267 0.455297060766329 no 1517 0.45023136572282 2029 1952075 SGTC_531 3788-1495 174 µM 0.123499597439368 0.45585137268987 no 1518 0.450855746524143 2031 2896655 SGTC_2849 9019321 12.99 µM 0.123387495111546 0.455890774043038 no 1519 0.45090012943067 2107 16489627 SGTC_594 1487-1584 10.8 µM 0.122442145936027 0.456223059441503 no 1520 0.451274430982449 2091 5013332 SGTC_1904 st060225 78 µM 0.121495134552069 0.456555959797149 no 1521 0.451649434111312 2193 66595 SGTC_2607 solasodine 47.35 µM 0.121226373389142 0.456650442248646 no 1522 0.451755867609779 2076 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_345 1362-0200 395 µM 0.120456441814653 0.456921123708896 no 1523 0.452060791366124 2044 1419823 SGTC_3204 9114183 49.47 µM 0.120378714062245 0.456948451226142 no 1524 0.452091576245419 2074 17027248 SGTC_15 0266-0086 27.098 µM 0.11875471092026 0.457519464496263 no 1525 0.452734845069367 2196 1712902 YIL048W NEO1 SGTC_2233 sulbentine 40.3845 µM 0.116999304524698 0.458136778865345 no 1526 0.453430302302901 2151 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_835 0312-0010 67.2 µM 0.116798772976262 0.458207305176754 no 1527 0.453509758060272 2145 1626196 SGTC_2283 7944793 200 µM 0.116356866390651 0.458362726966842 no 1528 0.453684859380605 2124 2970533 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.114812961001597 0.458905779644774 no 1529 0.454296687801295 2187 94937 An inhibitor of serotonin biosynthesis. SGTC_2932 9016711 44.54 µM 0.112009280795754 0.459892140431462 no 1530 0.455408023935243 2214 7117328 SGTC_340 k038-0059 454 µM 0.111254146485648 0.460157846165378 no 1531 0.455707407701979 2178 23733424 SGTC_3102 9121669 49.47 µM 0.110963318654855 0.460260183206475 no 1532 0.455822717261452 2106 41905072 SGTC_1170 0310-0127 64.8 µM 0.110516779400666 0.460417317396122 no 1533 0.455999771672278 2158 774975 SGTC_2300 7976697 71.57 µM 0.110280171314998 0.46050058071275 no 1534 0.456093591168024 2102 2236109 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.109552995783356 0.460756487469646 no 1535 0.456381945058537 2221 688801 SGTC_218 alverine citrate 93.75 µM 0.108891278344643 0.460989372419084 no 1536 0.456644362190974 2188 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_360 0957-0399 1.01 µM 0.108738474098049 0.461043152276422 no 1537 0.456704962427454 2197 6752301 YPR165W RHO1 SGTC_2552 juarezic acid 87.02 µM 0.108129676520805 0.46125742725291 no 1538 0.456946413850045 2242 1549512 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.108058392103142 0.461282517555593 no 1539 0.456974686561047 2185 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2407 paclitaxel 400 µM 0.107421269063106 0.461506775500037 no 1540 0.457227390930907 2109 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2781 5567276 71.43 µM 0.107355453025048 0.461529942476676 no 1541 0.457253496766746 2170 2853274 SGTC_90 0870-0863 4.608 µM 0.106043727785222 0.461991691528784 no 1542 0.457773829001908 2183 1738164 SGTC_1072 oxiconazole 14.9 nM 0.105646971010234 0.462131366617883 no 1543 0.457931227890796 2229 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1743 st037606 46.3785 µM 0.10451250742872 0.462530771271172 no 1544 0.458381321571642 2150 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3046 9092212 49.47 µM 0.103585388565024 0.462857205228257 no 1545 0.458749191757816 2208 25236637 SGTC_2835 9006588 71.43 µM 0.102798243791058 0.463134374645495 no 1546 0.459061549566697 2052 2345538 SGTC_3183 9108214 49.47 µM 0.102093013217626 0.463382715639339 no 1547 0.459341423341358 2214 4974831 SGTC_3221 9128209 49.47 µM 0.101377151938055 0.463634814740728 no 1548 0.459625536565914 2134 16460723 SGTC_468 gf-109203x 121 µM 0.101041624248936 0.463752979857167 no 1549 0.459758708932158 2224 2396 A protein kinase C inhibitor. SGTC_2355 9061122 103.12 µM 0.0995736579875179 0.464270001192556 no 1550 0.4603414038735 2213 5302957 SGTC_2937 9044753 11.33 µM 0.0993657530216363 0.464343230732173 no 1551 0.46042393664414 2214 6465530 YGL099W LSG1 SGTC_2157 5649910 96.377 µM 0.0972714069713924 0.465080980868463 no 1552 0.461255431115809 2152 2858091 SGTC_734 2023-0417 80 µM 0.0953379243854412 0.465762172192086 no 1553 0.462023210262729 2194 3935732 SGTC_3121 9125696 49.47 µM 0.0951389643833763 0.465832274142353 no 1554 0.462102224661152 2252 1235365 SGTC_2558 carylophyllene oxide 100 µM 0.0921465211479776 0.466886764022529 no 1555 0.46329081356049 2267 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2303 7774051 200 µM 0.0918458344542309 0.466992734254215 no 1556 0.463410263653543 2215 2953184 SGTC_318 1488-0629 67.2 µM 0.0910962731452863 0.467256910372005 no 1557 0.463708046965441 2130 3662576 SGTC_1873 rapamycin 2 nM 0.0900541532787885 0.46762422005391 no 1558 0.464122090754132 2175 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_810 3825-7150 143 µM 0.0884525507207109 0.468188780847168 no 1559 0.464758497747979 2254 22330411 YGL099W LSG1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0879605736595567 0.468362214397697 no 1560 0.464954006148851 2261 16725076 SGTC_2791 5663188 71.43 µM 0.0876744040179237 0.468463098729307 no 1561 0.465067731949685 2226 54690634 SGTC_1097 itavastatin 7.23 µM 0.0870383266719146 0.468687344426986 no 1562 0.46532052370593 2255 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0861056321163313 0.469016178894201 no 1563 0.465691223237108 2262 4114 Related to psoralen; DNA damaging agent. SGTC_2058 5236698 133 µM 0.0851897919916071 0.469339091665872 no 1564 0.466055252945194 2207 766665 SGTC_2292 7671323 168.05 µM 0.083913410229895 0.469789160109929 no 1565 0.466562638672771 2161 937504 SGTC_2305 7443522 69.23 µM 0.0796136392264407 0.471305594773678 no 1566 0.468272273559004 2198 5415886 SGTC_1149 3909-7961 23.3 µM 0.0784310041259555 0.471722758061829 no 1567 0.468742605879127 2112 735261 SGTC_3110 9122132 49.47 µM 0.0782247094606153 0.471795529734611 no 1568 0.468824653465408 2241 918317 SGTC_3022 9087993 49.47 µM 0.0778273939459617 0.471935687801592 no 1569 0.468982677658189 2270 17173644 SGTC_2433 5607874 27.82 µM 0.0777399031150564 0.471966551764971 no 1570 0.469017476020189 2248 2252428 SGTC_646 4092-0839 27.3 µM 0.0754205565244571 0.472784803779138 no 1571 0.469940052023725 2240 877796 SGTC_1757 st041620 31.8375 µM 0.0750459673667079 0.472916967523401 no 1572 0.470089069156616 2181 5289815 SGTC_1379 2144-0755 36.5 µM 0.073400413919113 0.473497592075997 no 1573 0.470743744112889 2259 5392327 SGTC_170 4197-0004 226 µM 0.0732204103865965 0.473561108778796 no 1574 0.470815362420414 2216 218692 SGTC_190 3970-0790 3.722 µM 0.0728750014781671 0.473682992906676 no 1575 0.470952793483938 2293 2832352 SGTC_1604 st002052 72.4 µM 0.0727217799191864 0.47373706084857 no 1576 0.471013758283106 2200 6254834 YHR062C RPP1 SGTC_2178 5812956 200 µM 0.0707788808004809 0.474422701534542 no 1577 0.471786870170918 2288 5403383 SGTC_822 1487-0950 154 µM 0.0664262499036133 0.47595899808324 no 1578 0.473519235975295 2308 1958375 SGTC_3296 9122258 64.045 µM 0.0663177279615495 0.47599730644917 no 1579 0.473562434711028 2238 4730474 SGTC_1315 1237-0019 3.69 µM 0.065777219459338 0.476188109847362 no 1580 0.473777596593709 2290 825140 SGTC_2816 7982706 58.44 µM 0.0643305626352548 0.476698816879295 no 1581 0.474353509192151 2230 2981853 SGTC_1640 st009078 66.4 µM 0.0641367358386637 0.476767245645072 no 1582 0.474430675539251 2294 690618 SGTC_1213 1315-0166 115 µM 0.0637258727729735 0.476912299329954 no 1583 0.474594251559746 2083 768401 SGTC_925 2064-1272 59.6 µM 0.0630885915348089 0.477137295158143 no 1584 0.47484797941934 2125 6815817 SGTC_3346 9158254 43.5805 µM 0.0630706804230753 0.4771436188854 no 1585 0.474855110717115 2231 17639500 SGTC_2854 9024559 71.43 µM 0.0617427634442978 0.477612471412603 no 1586 0.475383842304181 2244 3163529 SGTC_1499 4480-0877 67.3 µM 0.0607305143136509 0.477969890781518 no 1587 0.475786914808558 2296 2861909 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0594392826605301 0.478425842960866 no 1588 0.476301112657636 2300 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1564 D-Arginine 115 µM 0.0584166493332255 0.478786969335207 no 1589 0.476708376584265 2222 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1425 4048-4433 7.33 µM 0.0577033181414348 0.479038881005422 no 1590 0.476992475303866 2305 23734946 SGTC_2698 st077697 67.5 µM 0.0576836924445459 0.479045811904976 no 1591 0.477000291804536 2231 3154499 SGTC_1778 st046819 58.9 µM 0.0576101163169199 0.479071795688362 no 1592 0.477029595701343 2307 671715 SGTC_166 k072-0058 166.424 µM 0.0564397844685892 0.479485116213997 no 1593 0.477495732013195 2321 5846229 SGTC_1611 st001856 99.4 µM 0.0563942478091158 0.47950119862792 no 1594 0.477513869624068 2261 647478 SGTC_3252 9135871 49.47 µM 0.0561493330138046 0.479587697005178 no 1595 0.477611421918066 2291 17682838 SGTC_704 1310-0270 142 µM 0.0543423538701499 0.480225910692453 no 1596 0.478331202938962 2258 5718033 SGTC_966 1300-0360 30.2 µM 0.0537112584052197 0.480448821675727 no 1597 0.478582606420572 2283 70588 SGTC_3268 9137683 49.47 µM 0.0535199972206774 0.480516378780746 no 1598 0.478658799001878 2290 1953228 SGTC_1173 0443-0020 122 µM 0.0524180878446777 0.480905605067306 no 1599 0.479097780956685 2261 5331295 SGTC_2133 5320837 200 µM 0.0523915417664475 0.480914982136567 no 1600 0.479108356777693 2304 2841355 SGTC_3222 9128301 49.47 µM 0.0509904182661478 0.481409926304784 no 1601 0.479666577866549 2293 4911358 SGTC_2478 5763493 32.33 µM 0.0495617545200574 0.4819146285137 no 1602 0.480235812313534 2281 1365576 YLR208W SEC13 SGTC_552 k242-0005 476 µM 0.0493771709079182 0.481979838261158 no 1603 0.480309360470954 2266 4088318 SGTC_3129 9127257 49.47 µM 0.0485931367169652 0.482256827420236 no 1604 0.480621769805899 2191 837894 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0476681589001853 0.48258362114553 no 1605 0.480990355379815 2265 75037 A free radical scavenger. SGTC_3329 9141233 27.5565 µM 0.0470456431371265 0.482803561935001 no 1606 0.481238424908097 2301 4909101 YNL103W MET4 SGTC_177 1327-0068 8.361 µM 0.0458196127555708 0.483236745467259 no 1607 0.481727013254264 2339 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2465 5809242 33.21 µM 0.0442086227562559 0.483805973712454 no 1608 0.482369054404699 2330 2731748 SGTC_3214 9129694 49.47 µM 0.0437577866762339 0.483965278384569 no 1609 0.482548738091898 2304 17158655 SGTC_2215 7188065 200 µM 0.0427002750252473 0.484338964214467 no 1610 0.482970230166352 2326 940217 SGTC_1628 st004252 77.7 µM 0.0412007888874048 0.484868851119166 no 1611 0.48356791238355 2321 692968 SGTC_3332 9141069 11.198 µM 0.0410503994938476 0.484921997061802 no 1612 0.483627858355921 2329 17332883 SGTC_3334 9142812 21.919 µM 0.0410335907351063 0.484927937107253 no 1613 0.483634558435128 2305 45283678 SGTC_1054 3429-0080 167 µM 0.0406824691589804 0.485052020686095 no 1614 0.483774518804495 2316 1162877 SGTC_75 0159-0059 199.013 µM 0.0389757564595095 0.485655179808357 no 1615 0.484454858732815 2326 5377270 SGTC_2859 9028643 45.46 µM 0.0385199523063181 0.485816268436582 no 1616 0.484636561824154 2307 17151580 SGTC_2140 5586273 200 µM 0.0375136419029661 0.486171923118513 no 1617 0.485037731568898 2349 854421 SGTC_2203 7227154 166.4 µM 0.0375000759089296 0.486176717748013 no 1618 0.485043139812094 2332 896304 SGTC_2806 7952793 58.44 µM 0.0370897523779143 0.48632173934155 no 1619 0.485206721412852 2305 2972490 SGTC_567 1080-0542 68.4 µM 0.036862389776662 0.486402097411082 no 1620 0.485297363981482 2347 5950415 SGTC_1458 k015-0034 6.33 µM 0.0365405973946052 0.486515831283171 no 1621 0.485425654135145 2287 3598957 SGTC_2623 humulene 100 µM 0.0361434936859995 0.486656184601332 no 1622 0.485583971010591 2304 6187145 An anti-inflammatory. SGTC_1782 st039423 80.636 µM 0.0349037893324535 0.487094359333395 no 1623 0.486078229502792 2303 2068169 SGTC_908 3448-7491 47.7 µM 0.0341916487827651 0.487346073195775 no 1624 0.486362162977411 2314 1203031 SGTC_195 4234-0266 16.654 µM 0.0339580964329307 0.48742862592962 no 1625 0.486455282807965 2314 2303354 SGTC_454 lyso-paf C-16 6.67 µM 0.0337758502598051 0.487493044066552 no 1626 0.48652794682802 2309 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2907 7721985 69.9 µM 0.0336302587528254 0.487544506197238 no 1627 0.486585996457239 2323 3267881 SGTC_1824 st053723 68.6 µM 0.033605312257558 0.487553324038744 no 1628 0.486595943046764 2307 675225 SGTC_3215 9129942 49.47 µM 0.0335579045215949 0.487570081275208 no 1629 0.486614845335764 2350 17682944 SGTC_2971 9092186 9.93 µM 0.0334856304205161 0.487595628080574 no 1630 0.486643662334948 2312 25236400 SGTC_1691 st019933 84.6 µM 0.0332077603481141 0.487693847591349 no 1631 0.486754454837055 2352 6176082 SGTC_1136 pergolide 1.05886 µM 0.0316165808468398 0.488256300449128 no 1632 0.487388910198223 2296 47811 A dopamine receptor agonist. SGTC_1911 st060208 74.3 µM 0.0313827569958597 0.488338954899981 no 1633 0.487482146151142 2330 688783 SGTC_529 4076-0302 30.3 µM 0.0309329612763755 0.488497954705307 no 1634 0.487661501598317 2285 5816522 SGTC_2404 5161160 200 µM 0.0309053416504121 0.488507718119836 no 1635 0.487672514969266 2340 2831543 SGTC_2832 7992762 51.95 µM 0.0291774617028579 0.489118529424662 no 1636 0.488361528267606 2326 2985177 SGTC_3147 9097027 49.47 µM 0.0288508365134705 0.489233995426532 no 1637 0.488491778029896 2319 25236841 SGTC_2040 5100729 123 µM 0.0281677261909167 0.489475486191394 no 1638 0.488764188887021 2338 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1327 1436-0082 2.18 µM 0.0275313282309557 0.489700466839044 no 1639 0.489017976498694 2249 15992205 SGTC_2257 7960413 200 µM 0.0275226363125377 0.489703539645839 no 1640 0.489021442758947 2296 2974689 YIL048W NEO1 SGTC_398 bronopol 33.3 µM 0.0273270319967052 0.489772690740407 no 1641 0.489099448250316 2317 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_393 acivicin 6.25 µM 0.0269024005153608 0.48992280981122 no 1642 0.489268789438615 2341 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1381 2324-0066 62.1 µM 0.026367042418803 0.490112075860233 no 1643 0.489482290672723 2329 10885928 SGTC_1220 1838-0075 193 µM 0.0261783969625061 0.49017876853862 no 1644 0.489557523351756 2324 5529645 SGTC_754 3474-0146 171 µM 0.0251605070462921 0.490538632439216 no 1645 0.489963468893601 2361 24762078 SGTC_84 0443-0269 128.823 µM 0.0232663960459836 0.491208295042878 no 1646 0.490718888262167 2366 6150058 SGTC_2085 5307070 144.047 µM 0.0230550383651474 0.491283022084508 no 1647 0.490803185164929 2352 2840351 SGTC_2957 9076800 11.52 µM 0.0212835803354422 0.491909345698508 no 1648 0.49150972093375 2349 16459615 SGTC_1613 st002381 52.1 µM 0.0212558996152009 0.491919132764285 no 1649 0.49152076144575 2374 551167 SGTC_636 0kpi-0074 126 µM 0.0197453383458487 0.492453228775596 no 1650 0.492123261524683 2352 616434 SGTC_2889 9059656 51.95 µM 0.0171292596319991 0.493378239066522 no 1651 0.493166748261604 2365 3949838 SGTC_2681 menadione 3.18 µM 0.0148248034270958 0.494193093485948 no 1652 0.494085975740665 2359 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1289 0976-0073 69.1 µM 0.0142685249498708 0.494389797002252 no 1653 0.494307875263231 2369 3391136 SGTC_2844 9010103 25.97 µM 0.0140966007330391 0.494450590748753 no 1654 0.494376456204559 2351 2480525 SGTC_723 4182-0001 115 µM 0.013141475794358 0.494788332698389 no 1655 0.494757460575542 2352 744821 YLR208W SEC13 SGTC_2989 9073649 71.4286 µM 0.0128099552157998 0.494905562652247 no 1656 0.494889707016965 2379 21367202 SGTC_1786 berberine 21.6 µM 0.0108933289520095 0.495583314735278 no 1657 0.495654276454161 2386 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1977 st070720 65.3 µM 0.0104599103797975 0.495736580850463 no 1658 0.49582717559169 2336 682188 SGTC_2483 5729050 27.16 µM 0.0103597676996595 0.495771993543137 no 1659 0.495867124576263 2385 2865180 SGTC_1680 diphenhydramine 100 µM 0.0099686085957976 0.495910316472201 no 1660 0.496023166419557 2367 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1495 4469-0029 237 µM 0.00954600137439698 0.496059760736896 no 1661 0.496191754281528 2388 793680 SGTC_2557 derrustone 83.84 µM 0.00672558765638677 0.497057141253816 no 1662 0.497316898951025 2369 629853 An antioxidant. SGTC_2260 7964312 200 µM 0.00609442248864857 0.497280342397805 no 1663 0.497568692245258 2397 231951 SGTC_3057 9095946 49.47 µM 0.00597008408192033 0.497324312725679 no 1664 0.497618295190261 2395 24540043 SGTC_1064 honokiol 6.76 µM 0.0053472407896883 0.497544571968087 no 1665 0.497866769731414 2384 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1658 st012944 20 µM 0.00497129924541392 0.497677518455679 no 1666 0.49801674671144 2389 24207260 SGTC_995 3931-2021 34.6 µM 0.00442591027615203 0.497870388118075 no 1667 0.498234323026129 2385 730143 SGTC_1647 st011722 22.4 µM 0.00400591165427775 0.498018915468796 no 1668 0.498401876743825 2395 2854783 SGTC_3083 9117465 49.47 µM 0.00381950396634247 0.498084836345837 no 1669 0.498476242082584 2394 16420915 SGTC_1526 st051518 75 µM 0.00227266843052711 0.498631858310719 no 1670 0.499093337254218 2397 673993 SGTC_371 0195-0006 7.36 µM 0.00210586199267132 0.498690847808448 no 1671 0.499159883235371 2372 3928593 SGTC_627 1391-0720 175 µM 0.00119403989081178 0.499013305425922 no 1672 0.499523647116261 2395 997839 SGTC_2893 9048488 25.97 µM 0.00112847269818075 0.499036492696356 no 1673 0.499549804623967 2403 6467338 SGTC_1091 telmisartan 47.6 µM 5.31894934890906e-05 0.499416757706145 no 1674 0.499978780462184 2404 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1340 1486-1359 257 µM 0 0.49943556774709 no 1675 0.5 2406 4309068 SGTC_2674 ligustilide 100 µM 0 0.49943556774709 no 1676 0.5 2406 5319022 A signalling regulator. SGTC_2836 9010338 19.48 µM -0.0012100875179857 0.499863505821732 no 1677 0.499517245043907 2407 2994051 SGTC_2764 methyldopa 94.69 µM -0.00151438817758374 0.499971119436239 no 1678 0.499395846757946 2413 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2149 5554786 194.827 µM -0.001677720195278 0.499971119436239 no 1679 0.499330686793411 2410 745063 YPR165W RHO1 SGTC_3062 9077494 49.47 µM -0.00300395801294427 0.499502105633845 no 1680 0.498801595942439 2394 16459633 SGTC_2181 6316240 54.2555 µM -0.00329678613070606 0.499398549292575 no 1681 0.498684775005507 2416 12779990 SGTC_1298 1079-1278 263 µM -0.00380746160888318 0.499217953061262 no 1682 0.498481046253198 2415 2840950 SGTC_910 3454-3003 490 µM -0.00454388671136268 0.498957522602341 no 1683 0.498187257711405 2412 820824 SGTC_400 oxethazaine 37.5 µM -0.0046778428707503 0.498910150193151 no 1684 0.49813381750382 2425 4621 A local anesthetic. SGTC_1612 st002233 45.4 µM -0.00516399091613027 0.498738228377182 no 1685 0.497939874844109 2420 1035021 SGTC_1902 st060212 70.5 µM -0.00588450505514573 0.498483425573248 no 1686 0.497652435682616 2410 688944 SGTC_2930 9013230 14.89 µM -0.00706246801360515 0.498066851832016 no 1687 0.497182506327448 2418 2995857 SGTC_2495 cafestol 54.53 µM -0.0072973893151695 0.497983774715796 no 1688 0.49708878870357 2464 16667697 An anti-infammatory. SGTC_2714 st079313 56.9 µM -0.00734883368635006 0.497965582039088 no 1689 0.497068265919124 2424 2939799 SGTC_743 1275-0778 158 µM -0.00804206651327986 0.497720429102088 no 1690 0.496791714228648 2422 2849257 YMR203W TOM40 SGTC_2482 5981709 142.65 µM -0.00852187406199486 0.497550751787917 no 1691 0.496600305277427 2431 877755 SGTC_3278 9139605 49.47 µM -0.00853070287426979 0.497547629604426 no 1692 0.496596783218949 2435 7958859 SGTC_425 3825-7017 13.1 µM -0.00934077163258762 0.497261161009944 no 1693 0.496273625451971 2474 3397440 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0103451616178274 0.496905975622824 no 1694 0.495872951247616 2425 2374 Ca(2+)-ATPase inhibitor. SGTC_334 1502-1024 68.5 µM -0.0113191649373786 0.49656153830146 no 1695 0.495484402953527 2457 3296216 SGTC_284 0988-0104 32.6 µM -0.0115246312774898 0.496488879447096 no 1696 0.495402439090069 2421 4666532 SGTC_1130 3454-2858 15.9 µM -0.0118995137387853 0.496356310442711 no 1697 0.495252892884129 2455 715628 YIL048W NEO1 SGTC_2958 9077254 16.72 µM -0.0119867420192693 0.496325464121369 no 1698 0.495218096316758 2443 16457351 SGTC_2529 gangaleoidin 93.61 µM -0.0123318977265518 0.496203407778497 no 1699 0.49508040929131 2438 4565183 SGTC_3275 9138069 49.47 µM -0.0123696103338882 0.496190071607396 no 1700 0.495065365285198 2475 17617007 SGTC_3097 9117246 49.47 µM -0.0136736333877585 0.495728937436201 no 1701 0.494545179495151 2425 16423892 SGTC_70 0141-0289 43.283 µM -0.014876601681356 0.495303543725087 no 1702 0.494065313505577 2500 352408 SGTC_714 4296-0578 26.1 µM -0.0151928437747531 0.495191715046171 no 1703 0.493939165422448 2452 1589775 SGTC_1206 3978-0017 132 µM -0.0155441166898065 0.495067499305603 no 1704 0.493799044353981 2493 3873677 SGTC_2122 5258151 111.688 µM -0.0160125321235098 0.49490186083648 no 1705 0.493612196894193 2450 2173356 SGTC_1797 st048695 56.8 µM -0.0174034048353647 0.494410033428175 no 1706 0.493057396450891 2424 592262 YIL048W NEO1 SGTC_3143 9086658 49.47 µM -0.0180370496764811 0.494185972634226 no 1707 0.49280464842261 2479 25236626 SGTC_522 1273-0010 11.6 µM -0.0189431331185151 0.493865579044844 no 1708 0.492443235226253 2563 5705015 SGTC_291 SEC14.278 35.5 µM -0.019154798866433 0.493790734018614 no 1709 0.492358808129383 2436 1068044 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0191828710255679 0.493780807717148 no 1710 0.492347611015548 2447 551469 SGTC_821 1114-0266 29.2 µM -0.0194537438468241 0.493685027421435 no 1711 0.49223956855731 2455 3123235 SGTC_2376 9072922 81.32 µM -0.019840472835609 0.493548281159988 no 1712 0.492085315787929 2510 17087968 SGTC_456 gingerol 170 µM -0.0201733132747632 0.493430590341612 no 1713 0.49195255823721 2465 442793 A herb. SGTC_2084 5306078 60.6385 µM -0.0202387747219793 0.493407443547838 no 1714 0.49192644822888 2464 679340 SGTC_694 1315-0438 43.2 µM -0.0202530107291823 0.493402409779953 no 1715 0.491920770047555 2459 6793154 SGTC_991 3996-0057 64.7 µM -0.02279819933276 0.492502463802202 no 1716 0.490905622188407 2466 715343 SGTC_2411 st077133 39.94 µM -0.0228497574567303 0.492484233891113 no 1717 0.490885058829633 2553 1403142 YNL221C POP1 SGTC_3210 9128157 49.47 µM -0.0229970662173367 0.492432148575831 no 1718 0.490826306575485 2507 17590849 SGTC_2647 atorvastatin 60.16 µM -0.0233101274082204 0.492321457076696 no 1719 0.490701446703089 2470 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1370 2001-0092 44.6 µM -0.0238716627787458 0.49212291210135 no 1720 0.490477488833133 2439 790957 SGTC_3146 9095609 49.47 µM -0.0247288930474322 0.491819820526373 no 1721 0.490135604402259 2468 17173999 SGTC_1394 3474-0001 65.7 µM -0.0248649785471757 0.491771705099922 no 1722 0.490081330831354 2481 5017666 YIL048W NEO1 SGTC_2888 9058547 12.99 µM -0.0249230431056837 0.491751175388482 no 1723 0.490058173600491 2460 16476514 SGTC_761 k216-0224 480 µM -0.0250995712358907 0.491688761002458 no 1724 0.489987771089898 2451 1340404 SGTC_1146 3579-1023 7 µM -0.0252819035975483 0.491624294649836 no 1725 0.489915054077644 2516 X1146 SGTC_1102 cgs 12066b 26.1 µM -0.0268093826517679 0.491084240180326 no 1726 0.489305884817494 2488 6438352 A 5-HT1B full agonist. SGTC_1629 st005085 44.9 µM -0.0270712234160368 0.490991665548885 no 1727 0.489201463366565 2454 24207091 SGTC_680 0417-1641 114 µM -0.0273653331015261 0.490887682717019 no 1728 0.489084174032421 2454 2835990 SGTC_1042 0350-0096 82 µM -0.0279769848134416 0.490671434512324 no 1729 0.488840253709383 2451 3122515 SGTC_2018 5133068 143 µM -0.028064462742554 0.490640507093043 no 1730 0.488805368762707 2456 785362 SGTC_3079 9117512 49.47 µM -0.0288115811773652 0.490376369120088 no 1731 0.488507432135698 2445 7185044 SGTC_2285 7945142 200 µM -0.0290282411739598 0.490299771429924 no 1732 0.48842103344057 2483 2970608 SGTC_1885 st057546 99.9 µM -0.0295144883928319 0.490127865534477 no 1733 0.488227131954577 2546 702008 SGTC_1445 4239-0156 97.7 µM -0.0306193437193717 0.489737266272258 no 1734 0.48778655766237 2488 4008346 SGTC_2970 9090938 41.86 µM -0.0318306593900112 0.489309041431953 no 1735 0.487303548180655 2468 17217104 SGTC_2490 carminic acid 95.39 µM -0.0376043863435024 0.487268088853776 no 1736 0.485001555300431 2471 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1078 idebenone 36.1 µM -0.0378316324544917 0.487187766180646 no 1737 0.484910961683245 2504 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3128 9127691 49.47 µM -0.0403993678562596 0.486280208348101 no 1738 0.483887367108473 2569 41316314 SGTC_418 lividomycin a 100 µM -0.0409380214049128 0.486089831840141 no 1739 0.48367265307182 2480 72394 An antibiotic. SGTC_2191 5911152 200 µM -0.0413678118491764 0.485937933128182 no 1740 0.483501336622207 2485 2875902 SGTC_2387 9077560 195.08 µM -0.0416385691606758 0.485842241756256 no 1741 0.483393413073246 2463 5303272 SGTC_535 2293-4129 48.2 µM -0.0417692587394333 0.485796053580852 no 1742 0.483341320794285 2465 396118 YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM -0.0421743154597317 0.485652900068085 no 1743 0.483179868815747 2493 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3159 9100096 49.47 µM -0.0423835358765255 0.485578958955005 no 1744 0.48309647651122 2463 25236875 SGTC_3242 9133940 49.47 µM -0.0429093831737279 0.485393120135519 no 1745 0.482886884475097 2596 17248444 SGTC_1255 0566-0045 221 µM -0.0429804323626901 0.485368011002097 no 1746 0.482858566075 2538 2788469 SGTC_74 000s-0487 160.283 µM -0.043486157351525 0.485189286981447 no 1747 0.482656999460768 2470 677548 SGTC_1738 st035555 74 µM -0.044291231005224 0.484904778816012 no 1748 0.482336130730468 2538 5331140 SGTC_2715 st079500 56.4 µM -0.0464543085703211 0.484140398735469 no 1749 0.481474075610072 2481 28246688 SGTC_2397 5161689 200 µM -0.047460301446074 0.483784924503417 no 1750 0.481073184758624 2530 2259942 SGTC_13 0199-0087 65 µM -0.0499409256154774 0.482908435216996 no 1751 0.480084732025368 2499 4589825 SGTC_300 r073-0011 5.04 µM -0.0502324372554249 0.48280543953473 no 1752 0.479968581490795 2499 2735780 SGTC_944 3370-0224 231 µM -0.0560418361779196 0.480753135150109 no 1753 0.477654239530462 2514 4580514 SGTC_1504 k297-0033 30 µM -0.0569479576105687 0.480433071422296 no 1754 0.477293325811295 2486 4388117 SGTC_324 1315-0088 19.6 µM -0.0572540055780853 0.48032497081134 no 1755 0.47717142922303 2492 6787421 SGTC_1463 k081-0032 34.1 µM -0.0580801289751036 0.480033179211476 no 1756 0.476842401225324 2503 977755 SGTC_3225 9130819 49.47 µM -0.0588730151538395 0.479753137250912 no 1757 0.476526625773723 2518 4547121 SGTC_3206 9114350 49.47 µM -0.0593135323147935 0.479597553920462 no 1758 0.476351191431634 2504 17087243 SGTC_1763 st044482 94.5 µM -0.0595986571507577 0.479496854228842 no 1759 0.476237643953942 2596 88505 SGTC_2107 5363541 170.161 µM -0.0596864219415978 0.479465857937951 no 1760 0.476202693087652 2509 244052 SGTC_2993 9054257 71.4286 µM -0.0606067457692002 0.479140830494367 no 1761 0.475836200527833 2509 6470217 YGL055W OLE1 SGTC_81 0411-0046 9.971 µM -0.0640424125085789 0.477927592751632 no 1762 0.47446822790172 2510 12925265 SGTC_2112 5488546 200 µM -0.0641810137595272 0.47787865267823 no 1763 0.474413047523535 2518 600757 SGTC_2863 9028737 58.44 µM -0.064865187885037 0.477637075835968 no 1764 0.47414066912059 2631 6460917 SGTC_2536 dehydroabietamide 32.04 µM -0.0658772465239094 0.477279740481613 no 1765 0.473737777933608 2570 3983547 SGTC_3004 9076122 71.4286 µM -0.0659238838257815 0.47726327432759 no 1766 0.473719212699184 2565 44782551 SGTC_1879 gemcitabine 100 µM -0.0664875056086133 0.477064280406661 no 1767 0.47349485238941 2530 60750 A nucleoside analog which inhibits DNA replication. SGTC_541 4513-1321 94 µM -0.0679814858343293 0.476536839271586 no 1768 0.472900186174188 2536 747515 SGTC_1488 4013-0813 75.9 µM -0.068796942128393 0.476248964394113 no 1769 0.472575626075323 2521 2910057 SGTC_3193 9111931 49.47 µM -0.0698361351860158 0.475882123263351 no 1770 0.472162042828932 2554 17087244 SGTC_1061 3448-9325 110 µM -0.0698653510689051 0.4758718101825 no 1771 0.472150415777542 2510 723482 SGTC_1853 st056710 91.2 µM -0.071215871498766 0.475395100042667 no 1772 0.471612974929924 2670 269167 SGTC_2694 st077685 81.9 µM -0.0713980517057771 0.475330796290253 no 1773 0.471540480083926 2537 2838096 SGTC_1228 0124-0032 52.5 µM -0.0717510686655343 0.475206194490247 no 1774 0.471400006971024 2574 X1228 SGTC_351 caspofungin 25 nM -0.0725701980589986 0.474917081774226 no 1775 0.471074071336608 2576 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1063 disulfiram 1.84 µM -0.0729124250414197 0.474796296247361 no 1776 0.470937903254439 2533 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2015 5119600 184 µM -0.0731062694765153 0.474727881855793 no 1777 0.470860776345027 2590 2828786 SGTC_443 clozapine 122 µM -0.0736916206571777 0.474521295752057 no 1778 0.470627883204045 2522 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3243 9134147 49.47 µM -0.0737267421072522 0.47450890066929 no 1779 0.470613909783368 2534 24282180 SGTC_546 peri-Naphthalide 147 µM -0.0747769665158998 0.474138266308589 no 1780 0.470196084277624 2611 223824 A penicillin ester. SGTC_2301 7769476 200 µM -0.0748967538398397 0.474095993618439 no 1781 0.4701484296826 2584 977820 SGTC_813 k007-0158 173 µM -0.076958813288444 0.473368343381701 no 1782 0.469328154993226 2591 6523916 SGTC_2437 5741531 144.16 µM -0.0771214858582147 0.473310943968572 no 1783 0.469263450329613 2603 2262990 SGTC_801 0866-0028 10.1 µM -0.0784924727085166 0.472827210045722 no 1784 0.468718158829571 2537 6849771 SGTC_1181 1222-0449 220 µM -0.0785676929849832 0.472800670755059 no 1785 0.468688242669408 2632 658318 SGTC_262 fenpropimorph 62.5 µM -0.0787327424456024 0.472742438268096 no 1786 0.468622600801176 2539 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1239 0337-0584 35.4 µM -0.0788522295434908 0.472700281384612 no 1787 0.468575080085458 2627 914301 YML130C ERO1 SGTC_3078 9116413 49.47 µM -0.0793255530597438 0.472533288587199 no 1788 0.468386840968652 2535 17177322 SGTC_3161 9100388 49.47 µM -0.0796010329907156 0.472436099008364 no 1789 0.468277286808933 2554 25236368 SGTC_2166 5933061 31.504 µM -0.0815570098031079 0.471746076079065 no 1790 0.467499494281009 2875 2877375 SGTC_523 1934-0222 13.7 µM -0.0820820047139703 0.471560884486974 no 1791 0.467290751494298 2559 1361595 SGTC_2055 5235184 200 µM -0.0823702458693086 0.471459210230771 no 1792 0.46717614799139 2631 2836034 SGTC_2895 9054447 58.44 µM -0.0838015747178132 0.47095435062167 no 1793 0.46660709799111 2551 2697450 SGTC_1214 0358-0031 63.7 µM -0.0854044811434922 0.470389027457212 no 1794 0.465969915371962 2804 4301366 SGTC_873 0591-4978 488 µM -0.0880383282538015 0.469460235732812 no 1795 0.464923106427869 2682 3305145 SGTC_1371 2421-0008 32.7 µM -0.0882122828083909 0.469398898729044 no 1796 0.464853977552921 2623 2827552 SGTC_2596 sinensetin 100 µM -0.0884400274904436 0.469318596230194 no 1797 0.464763474290787 2609 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_930 2810-3379 265 µM -0.088834621421061 0.469179465844837 no 1798 0.464606671268098 2651 1015764 SGTC_2682 pyrogallin 40.03 µM -0.0893462626665547 0.468999071201034 no 1799 0.464403364382423 2578 822798 An ATP competetive kinase inhibitor. SGTC_212 3807-4682 38.772 µM -0.0903659091269292 0.468639582922182 no 1800 0.463998223200193 2635 3125501 YBL034C STU1 SGTC_2123 5259487 200 µM -0.0912974625793245 0.468311175205497 no 1801 0.46362811706925 2623 2173474 SGTC_3164 9100705 49.47 µM -0.0926500143753369 0.467834388141402 no 1802 0.463090804434126 2691 17174235 SGTC_2271 7849410 118.62 µM -0.0952029888280263 0.466934567229993 no 1803 0.462076798015456 2547 972430 SGTC_499 genistein 192 µM -0.0953484667263717 0.466883297161305 no 1804 0.462019023549799 2563 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1736 st036774 51 µM -0.0953984157095979 0.466865694010574 no 1805 0.461999187210591 2780 1272247 SGTC_1933 st074711 15.9 µM -0.0960003264102633 0.466653572180201 no 1806 0.461760156661657 2558 17250958 SGTC_2505 galangin 7.89 µM -0.0975282663896096 0.466115147231082 no 1807 0.46115344394547 2559 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_35 0133-0054 64.071 µM -0.0979912193771266 0.465952021187447 no 1808 0.460969632866692 2603 99677 SGTC_721 1187-1332 279 µM -0.100391309918211 0.465106417962162 no 1809 0.460016834297146 2554 25730 SGTC_2430 5571206 200 µM -0.100652520467681 0.465014397337333 no 1810 0.459913151530022 2628 1731771 SGTC_2254 7938975 95.19 µM -0.101897853004044 0.464575710855481 no 1811 0.459418877074036 2757 2969277 SGTC_1308 1187-1617 41.4 µM -0.102082238875127 0.464510761899708 no 1812 0.459345699341979 2564 2882570 SGTC_2469 5655019 90.81 µM -0.103249663043065 0.464099564878799 no 1813 0.458882412543821 2753 2788239 SGTC_1137 ixabepilone 100 µM -0.103741914824781 0.463926192522267 no 1814 0.458687081436536 2583 154225 A novel microtubule stabilizer. SGTC_1243 0416-0003 5.65 µM -0.105211956152539 0.463408481049445 no 1815 0.458103811870907 2656 2141977 SGTC_740 k014-0057 261 µM -0.105560501010997 0.463285741397266 no 1816 0.457965532609494 2698 4012779 SGTC_202 3594-0513 34.79 µM -0.106231840232541 0.46304933995759 no 1817 0.45769920451032 2560 708429 SGTC_2258 7960471 200 µM -0.106432705223588 0.462978611075017 no 1818 0.45761952271178 2663 2974708 SGTC_481 bay k-8644 50 µM -0.10711760707678 0.462737451217299 no 1819 0.457347839553387 2606 2303 A calcium channel antagonist. SGTC_3116 9124943 49.47 µM -0.107477346680399 0.462610789276155 no 1820 0.457205147971132 2600 41905195 YPL160W CDC60 SGTC_2381 9035592 200 µM -0.107655547551339 0.462548047328421 no 1821 0.457134466207628 2628 4749657 SGTC_846 0335-0850 148 µM -0.108426514421227 0.462276611807021 no 1822 0.456828684824484 2608 6819598 SGTC_2241 6772625 37.8075 µM -0.110464370005765 0.461559225693775 no 1823 0.456020552758367 2570 2285411 SGTC_2821 7996764 71.43 µM -0.110988157987611 0.461374856768186 no 1824 0.455812868634453 2710 2987135 SGTC_1350 1495-0454 146 µM -0.111412531331342 0.46122548703711 no 1825 0.455644611680874 2718 1069057 SGTC_1236 0330-0013 258 µM -0.112753744449988 0.460753446692012 no 1826 0.455112895488664 2648 4617066 SGTC_2815 7968870 71.43 µM -0.113613176751205 0.460450998272763 no 1827 0.454772220726689 2621 2977326 YHR190W ERG9 SGTC_758 0868-0029 16 µM -0.114112677136298 0.460275226340312 no 1828 0.454574236484522 2711 762687 SGTC_709 3807-1509 243 µM -0.11441663413093 0.460168269041805 no 1829 0.454453764228781 2583 1886677 YPL242C IQG1 SGTC_3339 9145883 14.936 µM -0.114611610003266 0.460099661864181 no 1830 0.454376488451821 2675 2030670 SGTC_3009 9080819 71.4286 µM -0.116300908789518 0.459505289436006 no 1831 0.453707032695697 2676 17027216 SGTC_968 1309-0633 340 µM -0.117098160130228 0.459224811371797 no 1832 0.453391133855127 2623 3761976 SGTC_1363 1636-0063 10.4 µM -0.118575115428772 0.458705262883537 no 1833 0.452805990623528 2620 6072185 SGTC_1916 st067606 49.2 µM -0.119153137162293 0.458501951362764 no 1834 0.452577016595586 2727 19590279 SGTC_870 0573-2213 57.6 µM -0.123319753375626 0.457036723457114 no 1835 0.45092694964533 2609 3916321 SGTC_1177 0983-0204 23.6 µM -0.124318343767942 0.456685646187972 no 1836 0.450531611871008 2708 766818 SGTC_1720 st037298 9.481 µM -0.124634460574606 0.456574515133625 no 1837 0.450406472753067 2704 597396 SGTC_3354 9151612 71.43 µM -0.126483254747736 0.455924638723063 no 1838 0.449674701682071 2731 27261949 SGTC_2974 9094440 9.66 µM -0.127182830538834 0.45567875892811 no 1839 0.449397847132908 2844 25236134 SGTC_1929 genistein trimethyl ether 50.5 µM -0.127665643916918 0.455509074479265 no 1840 0.449206789870302 2639 136420 SGTC_1034 k072-0165 12.7 µM -0.12797800711736 0.45539929895676 no 1841 0.449083188841577 2739 5835461 SGTC_1384 3089-0840 101 µM -0.128216882578311 0.455315351933266 no 1842 0.448988669988411 2659 1069836 SGTC_2803 7707263 71.43 µM -0.128411590435601 0.455246928025342 no 1843 0.448911629626819 2665 2199229 SGTC_2336 9001819 198.65 µM -0.128807008897644 0.455107974821962 no 1844 0.448755179718185 2802 2989602 SGTC_855 0428-0020 25 µM -0.129449772198984 0.454882114395583 no 1845 0.448500883215505 2655 6812414 SGTC_500 h-89 112 µM -0.131234585468864 0.454255026035027 no 1846 0.447794868647 2815 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2684 capsaicin 100 µM -0.131505500869338 0.454159850714125 no 1847 0.447687717651088 2734 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1735 st034310 56.75 µM -0.13362960046512 0.453413724684965 no 1848 0.446847738159893 2859 871153 SGTC_2129 girgensonine 121.053 µM -0.133694058363854 0.453391085311311 no 1849 0.446822251861185 2699 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2145 5634607 200 µM -0.134280551302949 0.453185099949049 no 1850 0.446590365881784 2627 308662 SGTC_3001 9076041 71.4286 µM -0.135656824852908 0.452701781014371 no 1851 0.446046290440807 2662 16004211 SGTC_604 1000-0114 314 µM -0.136434601472781 0.452428672821276 no 1852 0.445738860696917 2732 1572745 SGTC_1581 himbacine 57.9 µM -0.136967626976746 0.452241519433158 no 1853 0.445528191918255 2643 5281825 An alkaloid muscarinic receptor antagonist. SGTC_967 1306-0166 352 µM -0.137128571656406 0.452185011384062 no 1854 0.445464584438075 2707 4437607 SGTC_688 0527-0193 473 µM -0.138683215790672 0.45163922226802 no 1855 0.444850240890074 2711 4007154 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.139180616123575 0.451464619118929 no 1856 0.444653712751736 2628 6708784 An antioxidant flavonoid SGTC_310 1273-0058 1.06 µM -0.139213937552211 0.451452922585446 no 1857 0.444640547588154 2702 2734232 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.142319192666662 0.450363098017264 no 1858 0.443413943638103 2713 6857784 SGTC_988 1497-1057 103 µM -0.142577974381828 0.450272292411358 no 1859 0.443311746817028 2658 3533044 SGTC_3298 9116858 71.43 µM -0.144079952640656 0.449745305002593 no 1860 0.442718667505539 2772 2506942 SGTC_1266 0828-0227 32.9 µM -0.144810653946295 0.449488961513311 no 1861 0.44243018513181 2773 3913820 SGTC_1356 1502-0781 85.8 µM -0.145718477447118 0.449170509666373 no 1862 0.44207181708805 2659 567702 SGTC_2614 arthonioic acid 13.39 µM -0.145920571250268 0.449099622421543 no 1863 0.441992045950042 2644 6710684 SGTC_2076 5212012 200 µM -0.146320269197819 0.448959427529177 no 1864 0.441834282777212 2617 604802 SGTC_2814 7977482 42.97 µM -0.146868796512609 0.448767040801361 no 1865 0.441617790786243 2803 6456762 SGTC_2045 5106652 78.05 µM -0.147313133442207 0.448611205927659 no 1866 0.441442433293155 2777 673349 SGTC_1569 carminic acid 40.6 µM -0.148596323898131 0.448161218553027 no 1867 0.440936086954856 2742 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2908 7930301 100 µM -0.149213882472585 0.44794467774195 no 1868 0.440692432998311 2667 2223178 SGTC_2728 chlorpromazine 9.18 µM -0.150078713251069 0.447641459461464 no 1869 0.440351257062481 2648 2726 A thorazine and dopamine antagonist. SGTC_2131 toluylene red 5.2905 µM -0.150567453107731 0.447470115921543 no 1870 0.440158468646006 2706 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3044 9093193 49.47 µM -0.152870769082105 0.446662746608962 no 1871 0.439250093910186 2790 25236277 SGTC_1908 st060353 56.5 µM -0.15324648846774 0.446531068536045 no 1872 0.439101949056077 2829 4227716 SGTC_2253 7938677 135.83 µM -0.153529531529048 0.446431874553226 no 1873 0.438990351788129 2888 2301972 SGTC_1263 0774-1208 64.8 µM -0.155013008442774 0.445912036951011 no 1874 0.438405531007446 2765 906585 SGTC_2795 7780010 54.55 µM -0.155491922183116 0.445744236572443 no 1875 0.438216760828285 2800 953673 SGTC_2625 euphol 100 µM -0.15605906082298 0.445545536785265 no 1876 0.437993233821957 2791 6708538 A triterpene alcohol. SGTC_1881 5652484 16 µM -0.156391657726778 0.44542901619803 no 1877 0.437862156218778 2759 2255129 SGTC_1198 1612-1005 86.7 µM -0.156626343297749 0.445346800287471 no 1878 0.437769669916202 2864 6998509 SGTC_1365 1672-3266 55.4 µM -0.156980669472236 0.445222675896048 no 1879 0.437630041366853 2760 6415873 SGTC_2367 9070478 135.38 µM -0.156993693954566 0.445218113377585 no 1880 0.437624908985147 2680 572802 SGTC_1688 st021091 57.6 µM -0.157408658333561 0.445072753809518 no 1881 0.437461395079311 2675 3656366 SGTC_2831 7999036 19.48 µM -0.158389083481169 0.444729346049677 no 1882 0.437075107659725 2973 2988270 SGTC_2533 agelasine 13.65 µM -0.158857319194795 0.444565354495351 no 1883 0.436890643972185 2796 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_476 mead acid 10 µM -0.158978665948037 0.44452285641647 no 1884 0.436842841078333 2681 5312531 An omega 9 fatty acid. SGTC_1369 1866-0067 208 µM -0.159650172021765 0.444287692997214 no 1885 0.436578327134564 2731 3531355 SGTC_501 nsc-95397 161 µM -0.160166592901432 0.444106854209479 no 1886 0.436374922310215 2863 262093 SGTC_1906 st060206 94.7 µM -0.161218104635051 0.443738674843435 no 1887 0.435960811100417 2803 5133468 SGTC_2592 piperlongumine 83.33 µM -0.162427465273119 0.443315285861014 no 1888 0.435484621925663 2768 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_508 roscovitine 141 µM -0.163204853507874 0.443043161631247 no 1889 0.435178572449523 2694 160355 A CDKinase inhibitor. SGTC_2812 7970281 58.44 µM -0.163874205145055 0.442808877057915 no 1890 0.434915086933727 2821 2233435 SGTC_1003 4049-0218 100 µM -0.164324169029432 0.442651393201776 no 1891 0.43473797808474 2857 295161 SGTC_2868 9035608 32.47 µM -0.165544818442713 0.442224221111921 no 1892 0.434257588209229 2654 6462614 SGTC_3058 9093861 49.47 µM -0.165780503291138 0.442141749795557 no 1893 0.434164844958491 2859 17217477 SGTC_1794 st048918 76.9 µM -0.165822886471673 0.44212691925367 no 1894 0.434148167334108 2662 672303 SGTC_1038 k292-0204 154 µM -0.166050924641873 0.442047126501912 no 1895 0.434058437172309 2688 4454212 SGTC_164 4100-3994 89.624 µM -0.169184644206825 0.440950847398791 no 1896 0.432825703912215 2712 4615967 SGTC_1113 artemisinin 1.17947 µM -0.169430931521404 0.440864706986296 no 1897 0.432728847683511 2753 2240 An anti-malaria and mitochondrial poison. SGTC_2025 5147754 141 µM -0.169836855792204 0.440722738733048 no 1898 0.432569220618922 2799 315777 YLR208W SEC13 SGTC_992 3909-8734 162 µM -0.170868026906996 0.440362130487765 no 1899 0.432163768865255 2754 4288319 SGTC_1969 st069479 40.1 µM -0.171298991147369 0.440211433709555 no 1900 0.431994336843728 2872 3895485 SGTC_778 3456-2434 196 µM -0.17131418224736 0.440206121942201 no 1901 0.431988364746125 2890 5539063 SGTC_1446 4239-0190 62 µM -0.171328924303314 0.440200967199274 no 1902 0.431982569196669 2724 1340085 SGTC_389 tpck 16.7 µM -0.171705215117831 0.440069395876751 no 1903 0.431834642819894 2773 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2073 5212005 126 µM -0.172630811015883 0.439745786412047 no 1904 0.431470815898456 2680 691789 SGTC_2916 7875993 68.79 µM -0.172692121620581 0.439724352243596 no 1905 0.431446718393645 2722 1299250 SGTC_2324 6149169 200 µM -0.172888152178789 0.439655821206897 no 1906 0.43136967230429 2790 2888231 SGTC_1156 4092-0367 4.88 µM -0.173084301731361 0.439587250380392 no 1907 0.43129258205999 2736 1357585 SGTC_2691 st077356 60.2 µM -0.173558013453373 0.439421655623403 no 1908 0.431106415770996 2874 2839272 SGTC_772 k072-0172 35.3 µM -0.173752485980239 0.439353677196183 no 1909 0.431029993489564 2740 5861980 SGTC_492 tmb-8 126 µM -0.174667598445443 0.439033821060271 no 1910 0.430670414514232 2775 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1694 st024011 44.9 µM -0.175550216656743 0.438725360237549 no 1911 0.430323658084837 2735 2787533 SGTC_2054 5233173 129 µM -0.177658022581539 0.437988866972767 no 1912 0.429495776923355 2860 6889 SGTC_3106 9121286 49.47 µM -0.178697501397338 0.437625739220752 no 1913 0.429087615601223 2930 15943471 SGTC_1247 0448-0043 5.84 µM -0.180138622450182 0.437122390183361 no 1914 0.42852187110217 2841 3089013 YGL099W LSG1 SGTC_1422 4031-0024 15.5 µM -0.182443197186575 0.436317669284777 no 1915 0.427617464086128 2727 782427 SGTC_2281 7943571 200 µM -0.183376396097715 0.435991885814615 no 1916 0.427251347505784 2855 1244024 SGTC_2564 betulinic acid 100 µM -0.183764370817456 0.435856455056177 no 1917 0.427099154026704 2977 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2364 9055074 200 µM -0.184466917353368 0.435611235522517 no 1918 0.426823588952687 2820 6470630 SGTC_2027 5150920 200 µM -0.184553792375545 0.435580914049992 no 1919 0.42678951579226 2813 786715 SGTC_1703 st026983 48.3 µM -0.184742337707881 0.435515108496618 no 1920 0.426715568506909 2846 1104023 SGTC_2670 beta-carotene 100 µM -0.185244427735417 0.435339879182693 no 1921 0.426518661883768 2801 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2996 9066192 71.4286 µM -0.185716093461222 0.435175279508412 no 1922 0.426333703560336 2780 6472854 SGTC_2645 abamectin 100 µM -0.186295204831177 0.434973199325749 no 1923 0.426106633816826 2824 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_869 0564-0080 44.1 µM -0.186440736210483 0.434922419002672 no 1924 0.426049574767515 2770 6843321 SGTC_3213 9129884 49.47 µM -0.187144602821716 0.434676833706311 no 1925 0.425773628942105 2837 17190742 SGTC_3265 9137266 49.47 µM -0.18725731894159 0.434637508392149 no 1926 0.425729442773585 2697 17224265 SGTC_244 nsc-207895 1.295 µM -0.190357839070779 0.433556028651113 no 1927 0.424514366549612 2710 42640 SGTC_1207 2099-0101 141 µM -0.193017079304335 0.432628865775623 no 1928 0.423472796125415 2847 5837381 SGTC_55 0767-0285 6.563 µM -0.194056617961504 0.432266523814169 no 1929 0.423065774848135 2863 3116166 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.19424083392797 0.432202319364655 no 1930 0.422993655424853 2904 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2852 9023854 51.95 µM -0.194630444785424 0.43206653491399 no 1931 0.422841133662263 2914 19798528 SGTC_1925 st057770 10.1 µM -0.194925906127692 0.43196356814296 no 1932 0.422725476513408 2741 5989122 SGTC_1603 st002045 67.8 µM -0.19521284560979 0.431863575620282 no 1933 0.422613161587656 2875 5887985 SGTC_894 0960-0238 55.9 µM -0.19552404741131 0.43175513311166 no 1934 0.422491356925802 2734 6741907 YDL195W SEC31 SGTC_3152 9099253 49.47 µM -0.196403515331017 0.43144869835859 no 1935 0.422147172504585 2852 25236131 SGTC_1293 1000-1278 195 µM -0.198016572346705 0.430886765047748 no 1936 0.421516048801022 2885 678847 SGTC_2308 7584454 197.62 µM -0.198561726666799 0.430696883696799 no 1937 0.421302797545863 2893 893577 SGTC_3281 9140613 49.47 µM -0.201239587714013 0.429764397991045 no 1938 0.420255619047688 2794 16013766 SGTC_551 k048-0028 34.9 µM -0.201305547293307 0.429741434444823 no 1939 0.420229832620826 2918 6836383 SGTC_31 0508-1974 57.237 µM -0.202247172933243 0.429413637448561 no 1940 0.419861748181198 2845 6810525 SGTC_279 1273-0055 2.93 µM -0.203606171382207 0.428940631249072 no 1941 0.419330635051559 2839 2847562 SGTC_2358 9037157 4 µM -0.203774188606742 0.428882159088004 no 1942 0.419264982063015 2865 2388925 SGTC_561 1550-0330 72.9 µM -0.204047460548186 0.428787060262186 no 1943 0.419158205433959 2768 6812934 SGTC_634 1611-4317 11.2 µM -0.206451881654645 0.427950498862503 no 1944 0.418218973948976 2748 2843522 SGTC_2659 sanguinarine 24.21 µM -0.206473002492763 0.427943151795866 no 1945 0.418210725639738 2769 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1558 st069300 45.6 µM -0.206534126421068 0.427921889448293 no 1946 0.418186855148488 2834 24208000 SGTC_2756 carbadox 75.1 µM -0.207182685092222 0.427696297089511 no 1947 0.41793359461848 2807 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2031 5180455 200 µM -0.208200839471099 0.427342193568081 no 1948 0.417536076574704 2777 29949 SGTC_2208 7283366 200 µM -0.211981292664853 0.426027905509228 no 1949 0.41606081448117 2856 898663 SGTC_3075 9116269 49.47 µM -0.212929408171437 0.425698418002243 no 1950 0.415691011962328 2979 17015205 YNL244C SUI1 SGTC_2987 9018338 71.43 µM -0.213946884151467 0.425344884170428 no 1951 0.415294239166288 2738 5055682 SGTC_3303 9125618 40.5795 µM -0.214804120048322 0.425047074187027 no 1952 0.414960020272403 2879 22695467 SGTC_2653 dihydrofissinolide 100 µM -0.215840932418376 0.424686935192005 no 1953 0.414555870397985 2842 6857746 SGTC_2656 pseudo-anisatin 100 µM -0.217811485038426 0.424002633024718 no 1954 0.413787997816086 2804 6708809 A neurotoxin. SGTC_802 4112-3352 742 µM -0.219499765972996 0.423416535798113 no 1955 0.413130381073096 2946 704594 SGTC_1284 0929-0043 16 µM -0.219873904328624 0.423286674227199 no 1956 0.41298468016114 2855 1239883 SGTC_2778 tioconazole 65.09 nM -0.220124887545584 0.423199563864503 no 1957 0.412886946340308 2755 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2075 5212009 200 µM -0.220527373464561 0.423059878321849 no 1958 0.41273022806466 2920 780898 SGTC_349 k015-0014 24 µM -0.221354412034852 0.422772879197548 no 1959 0.412408242944632 2774 2196908 SGTC_2372 9071633 200 µM -0.221695005780225 0.422654698180258 no 1960 0.412275659095571 2901 21321366 SGTC_48 0382-0018 55 µM -0.222940904176024 0.42222244915869 no 1961 0.411790750252675 3060 762596 SGTC_1744 st037937 38.9 µM -0.226281051265812 0.421064090006215 no 1962 0.410491417553164 2990 1016152 SGTC_897 1000-0139 31.4 µM -0.226364099571578 0.421035297610234 no 1963 0.410459123827866 2960 6151020 SGTC_1745 st081495 74 µM -0.226614945192532 0.420948333362514 no 1964 0.410361585012375 2804 13842402 YBL026W LSM2 SGTC_274 sirtinol 40.1 µM -0.227021838552734 0.420807278012327 no 1965 0.410203380384904 2833 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2765 myclobutanil 7.74 µM -0.228505447125983 0.420293050318555 no 1966 0.409626660969973 2912 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_701 4424-0219 185 µM -0.228839830250185 0.420177169859493 no 1967 0.409496704013891 2966 2911779 SGTC_2880 9042983 58.44 µM -0.228883603089888 0.42016200089549 no 1968 0.409479692572324 2960 6464714 SGTC_1545 lovastatin 49.4 µM -0.229503386213347 0.41994723506327 no 1969 0.409238844521869 2866 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.233257040149007 0.418647039062623 no 1970 0.407780907762041 2819 688664 SGTC_257 daunorubicin 18.5 µM -0.236710055552704 0.41745176261903 no 1971 0.406440866718635 2929 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2978 9011784 42.97 µM -0.238145497728523 0.416955101701887 no 1972 0.405884123776915 2960 2994934 SGTC_390 dec-rvkr-cmk 16.7 µM -0.238414038586056 0.416862201643071 no 1973 0.40577999004968 2886 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.238783900861531 0.41673425766379 no 1974 0.405636577213806 2911 140250 A respiratory chain inhibitor. SGTC_2788 5282734 71.43 µM -0.238835447484433 0.416716427185765 no 1975 0.405616591191717 2990 743706 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.239662655917042 0.416430311208145 no 1976 0.405295893764776 2943 7104 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.240363727674886 0.416187858209877 no 1977 0.405024147568667 2849 688669 SGTC_1086 cerivastatin 2.18 µM -0.242438514486116 0.415470517863542 no 1978 0.404220197042181 2818 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2184 6075246 200 µM -0.242790683334835 0.415348786295903 no 1979 0.404083776643513 2894 2267320 SGTC_1717 st033143 58.0435 µM -0.243039298711944 0.415262854172844 no 1980 0.403987476996825 3002 674616 SGTC_2370 9071495 200 µM -0.24441541305837 0.414787283528843 no 1981 0.403454552905516 2923 21791103 SGTC_1633 st005664 67.9 µM -0.244788417412748 0.414658398626951 no 1982 0.403310131347886 2804 2063822 SGTC_2458 5808907 16.39 µM -0.247044040008304 0.413879205303314 no 1983 0.402437070562769 2995 2731747 SGTC_169 k015-0017 16.025 µM -0.247296503629039 0.413792014067617 no 1984 0.402339382237645 3041 1840002 SGTC_104 0074-0074 590.992 µM -0.247731616452217 0.413641752790625 no 1985 0.402171033909367 2784 3943124 SGTC_1126 isoteolin 1.0172 µM -0.248154645710096 0.41349567655861 no 1986 0.402007378197074 2840 133323 SGTC_3238 9133470 49.47 µM -0.248243303793551 0.413465063552818 no 1987 0.401973081559713 2989 3534688 SGTC_818 4072-2707 53.5 µM -0.248867402128192 0.413249581730383 no 1988 0.401731675716632 2805 882871 SGTC_3017 9080681 49.47 µM -0.249083929423656 0.413174827664556 no 1989 0.401647930116011 2918 16451914 SGTC_1635 st007035 42.4 µM -0.249674584346592 0.412970925474064 no 1990 0.40141950729117 2867 3716403 SGTC_2768 sulfasalazine 50.2 µM -0.251924662458847 0.412194383126548 no 1991 0.400549648182292 2948 5384001 An antioxidant and salicylic acid derivative. SGTC_1075 aripiprazole 15.2 µM -0.252228550213251 0.412089532280899 no 1992 0.400432205716626 2842 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2176 5809774 33.9695 µM -0.252551507939649 0.411978108572594 no 1993 0.400307403210613 2979 2870539 SGTC_2708 st078559 56 µM -0.2525761744275 0.411969598674372 no 1994 0.400297871608891 2924 17250902 SGTC_2340 7987427 183.45 µM -0.253041924459459 0.411808923445143 no 1995 0.400117908059195 2988 2239331 SGTC_517 1365-0151 113 µM -0.25312589632502 0.411779956262169 no 1996 0.400085463993775 3022 768657 SGTC_898 1000-0849 28.3 µM -0.254206964158884 0.411407070897244 no 1997 0.399667835336057 2929 6751807 SGTC_1815 st051655 58.2 µM -0.255795922752261 0.410859147546955 no 1998 0.399054211185385 2951 5984156 SGTC_811 0416-0114 265 µM -0.257125134133717 0.410400926801767 no 1999 0.398541087716769 2939 6612453 SGTC_3021 9087658 49.47 µM -0.258451896054058 0.409943672405475 no 2000 0.39802908468556 2908 25237042 SGTC_933 2914-0560 114 µM -0.258482566187758 0.409933103715319 no 2001 0.398017251023947 3066 463887 SGTC_2033 5192550 145 µM -0.259614383390689 0.409543134109256 no 2002 0.397580620163552 2901 182073 SGTC_1995 st072814 61.1 µM -0.25969804668034 0.409514311322778 no 2003 0.397548349741703 2876 5769371 SGTC_1940 st075990 51.1 µM -0.25984879743819 0.409462377510139 no 2004 0.397490204257786 3115 1084979 SGTC_78 0336-0123 156.75 µM -0.260792775006024 0.409137212289787 no 2005 0.397126158204632 2804 6765896 SGTC_525 k781-2675 26.7 µM -0.261412683683963 0.408923710760163 no 2006 0.396887138425165 2866 3651118 YDL195W SEC31 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.26264253563404 0.408500219901988 no 2007 0.396413055976302 2909 4330530 SGTC_483 fpl-64176 144 µM -0.266962181796873 0.407013629839323 no 2008 0.394749139591865 2880 3423 SGTC_2017 5132927 60.65 µM -0.267438741307528 0.406849705269077 no 2009 0.394565687047328 2899 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2382 9035899 200 µM -0.268651674328891 0.406432560286241 no 2010 0.394098871604 2896 6462679 SGTC_1020 4335-0961 93.3 µM -0.269001819232038 0.406312160182143 no 2011 0.393964141354184 2834 669075 SGTC_217 ketoconazole 989 nM -0.2703977560431 0.405832244390926 no 2012 0.393427133123367 2964 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1017 4239-0030 168 µM -0.270683368443318 0.405734069750921 no 2013 0.393317284747536 2887 1149593 SGTC_770 0389-1121 67.2 µM -0.2718138960245 0.405345527428901 no 2014 0.392882559943728 3071 6753108 SGTC_1854 st056233 32.9 µM -0.272096801293201 0.405248312469022 no 2015 0.392773794495788 2974 5393174 SGTC_2919 7978188 46.38 µM -0.272490815728356 0.405112926720554 no 2016 0.39262232609193 3066 2980291 SGTC_1208 2323-2347 50.3 µM -0.275116754730246 0.404210928916811 no 2017 0.391613269838278 3050 5412760 SGTC_3038 9091290 49.47 µM -0.275171467724905 0.40419214065478 no 2018 0.391592253280992 3048 25236843 SGTC_2029 5175081 200 µM -0.276190207531204 0.403842349171801 no 2019 0.391200989046556 2876 1380876 SGTC_2710 st078562 53.7235 µM -0.276587401034341 0.40370599080317 no 2020 0.391048469974553 2860 17250908 SGTC_356 1634-0012 32.5 µM -0.276805331039342 0.4036311793945 no 2021 0.390964793743548 3002 735457 SGTC_2250 alverine citrate 130 µM -0.277236906504627 0.403483037790512 no 2022 0.390799101270981 2844 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2964 9083345 53.42 µM -0.277852919203795 0.403271610678292 no 2023 0.39056263314104 2955 17741579 SGTC_125 0133-0007 11.75 µM -0.278229101074675 0.403142511904432 no 2024 0.390418248510327 3028 26541 SGTC_463 ikarugamyin 104 µM -0.278865753030013 0.402924048594446 no 2025 0.390173925724942 2923 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2869 9037858 32.47 µM -0.279552460909512 0.402688442864009 no 2026 0.389910442006633 2861 27187042 SGTC_6 0844-0013 19.835 µM -0.280356643510959 0.402412577122434 no 2027 0.389601948582986 2964 1584900 SGTC_1670 st016595 4.04 µM -0.281148329324746 0.40214104572583 no 2028 0.389298316997457 2950 597879 SGTC_2383 9036125 200 µM -0.281938964224526 0.401869921894252 no 2029 0.38899515590467 2902 79580 SGTC_2139 5578692 56.4705 µM -0.282043767662094 0.401833986332284 no 2030 0.388954975136649 2998 650991 YMR113W FOL3 SGTC_2841 9004761 38.96 µM -0.282430716283695 0.401701314515267 no 2031 0.388806632538026 2923 2991039 SGTC_2118 5526350 200 µM -0.283611522962608 0.401296525258062 no 2032 0.388354052762834 3009 743594 SGTC_2426 5582046 32.21 µM -0.286199371273844 0.400409762705856 no 2033 0.387362712632196 3098 2251934 SGTC_2329 6138490 200 µM -0.286467066050931 0.400318062539333 no 2034 0.387260207225236 3140 720019 SGTC_1951 sophoraflavanone G 9.2 µM -0.287779349390174 0.399868612990338 no 2035 0.386757822888029 2920 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_549 1661-1316 519 µM -0.288713814935399 0.399548644685387 no 2036 0.386400194958184 3050 2857282 SGTC_3030 9087619 49.47 µM -0.289796489379558 0.399178012855996 no 2037 0.385985966875388 2959 25236973 SGTC_585 0kpi-0023 191 µM -0.290479083756777 0.398944387076239 no 2038 0.385724875020314 3042 64601 SGTC_2428 5615643 7.78 µM -0.29079925476656 0.39883481733042 no 2039 0.385602427668297 3045 2253075 SGTC_2628 lathosterol 100 µM -0.292422216223089 0.398279526088398 no 2040 0.384981912050022 3079 6710616 SGTC_2890 9046729 58.44 µM -0.292902780079152 0.398115142116546 no 2041 0.384798231904811 2944 903329 SGTC_2431 5490079 200 µM -0.29327017695234 0.397989480779033 no 2042 0.384657823650422 2986 5722345 SGTC_2109 5483026 200 µM -0.293557352606368 0.397891264999873 no 2043 0.384548084113872 2952 759335 SGTC_578 3460-0051 92 µM -0.295592215317556 0.39719551557791 no 2044 0.383770759696055 3027 2876744 SGTC_2464 5717415 7.67 µM -0.296957386570809 0.39672892663949 no 2045 0.383249521474078 2945 5285744 SGTC_2675 theaflavin digallate 100 µM -0.298913244255277 0.396060710331364 no 2046 0.382503120701233 2957 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1337 1486-1011 40.3 µM -0.299562077260295 0.395839104694907 no 2047 0.382255607174399 2939 X1337 SGTC_987 1497-1013 404 µM -0.30030997794883 0.395583704761212 no 2048 0.381970361496948 2927 1676435 SGTC_664 1222-0054 14.9 µM -0.301960074456185 0.395020373510459 no 2049 0.381341249519057 2955 6813991 SGTC_250 brefeldin a 552.239 µM -0.30249997684879 0.394836102233502 no 2050 0.381135475549682 2913 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_768 0384-0033 77.3 µM -0.303123524726034 0.394623311624914 no 2051 0.380897863446877 2957 3965305 YMR134W ERG29 SGTC_2743 auranofin 4.32 µM -0.303529862563541 0.394484662561281 no 2052 0.380743046590788 2966 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_815 1582-0027 36.9 µM -0.303538854822669 0.39448159440766 no 2053 0.380739620708559 3026 3128206 SGTC_452 diindolylmethane 8 µM -0.306543826362546 0.393456667576153 no 2054 0.379595308102305 3061 3071 Inhibits expression of several cancer promoting factors. SGTC_937 3122-0005 46.7 µM -0.30793497158679 0.392982429285271 no 2055 0.379065907218696 3107 759535 SGTC_2939 9044578 71.43 µM -0.308970844661357 0.392629405573842 no 2056 0.378671852520138 2910 2653634 SGTC_2920 7982904 15.77 µM -0.309458441910958 0.392463263846142 no 2057 0.37848641011175 3061 6456808 SGTC_2069 5228469 200 µM -0.310242771487622 0.392196055985316 no 2058 0.37818817353454 3063 2835210 SGTC_2238 6671620 73.2395 µM -0.310592374116947 0.39207696863378 no 2059 0.37805526261949 2880 729941 SGTC_1971 st069429 63.5 µM -0.310985188620736 0.391943173808855 no 2060 0.37790594075693 3093 1246522 YGL099W LSG1 SGTC_2126 5251174 33.877 µM -0.311333116803509 0.391824678186523 no 2061 0.377773696910448 3124 790722 SGTC_656 4090-1979 187 µM -0.312344472252811 0.391480292870226 no 2062 0.377389372716851 3087 22330961 SGTC_2943 9068529 45.32 µM -0.313459617553941 0.391100663767734 no 2063 0.37696574816776 2937 3270634 SGTC_1771 st048882 4.1505 µM -0.316005298398794 0.390234426440435 no 2064 0.375999243257382 2955 4580403 SGTC_32 0928-0142 34.1 µM -0.316937108558131 0.389917488573112 no 2065 0.375645661928949 3047 2244242 SGTC_3012 9080433 71.4286 µM -0.317234364579697 0.389816397859695 no 2066 0.375532888181763 3069 17688859 SGTC_286 k060-0067 22.9 µM -0.31766973733694 0.389668349913499 no 2067 0.375367734551251 2991 5985051 SGTC_1321 1326-2144 215 µM -0.318535508098292 0.389373993267159 no 2068 0.375039382301861 3073 3513030 SGTC_2237 6667747 47.222 µM -0.318766849179479 0.389295349483633 no 2069 0.374951659194951 2943 729940 YDL015C TSC13 SGTC_1456 k015-0012 13 µM -0.320428784154754 0.388730512596318 no 2070 0.374321654147284 3173 2989616 SGTC_1716 st033144 30.6155 µM -0.320754971353423 0.388619679893578 no 2071 0.374198042678234 3141 674617 SGTC_2485 5633444 17.78 µM -0.327044056938005 0.386484541368771 no 2072 0.371817281574326 3065 5724239 SGTC_1154 4088-0362 150 µM -0.327332276138654 0.386386772991155 no 2073 0.371708291510605 2965 6618304 SGTC_2569 tetrandrine 100 µM -0.327904074896271 0.386192831427849 no 2074 0.371492096305416 3033 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1487 3970-0795 2.82 µM -0.328951736065788 0.385837561604955 no 2075 0.371096084317813 3085 3765103 SGTC_2094 5332512 191.667 µM -0.329153834932744 0.385769039357197 no 2076 0.371019707393291 3133 755774 SGTC_2808 7946468 45.46 µM -0.329187372265098 0.385757668765396 no 2077 0.371007033502418 3061 2970879 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.329470379143207 0.385661721224985 no 2078 0.370900089654462 3091 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3124 9127567 49.47 µM -0.331454398237919 0.384989277946132 no 2079 0.370150640453753 3185 17592030 SGTC_133 0724-0033 378.92 µM -0.331586236677714 0.384944606193458 no 2080 0.370100856842542 2907 280309 SGTC_2823 7987624 58.44 µM -0.332976561631781 0.384473605615947 no 2081 0.369575987841442 3233 2239440 SGTC_2226 7298446 200 µM -0.33322786776157 0.384388488777724 no 2082 0.369481141819185 3099 3283010 SGTC_314 1671-0008 2.74 µM -0.334262992280357 0.384037953166507 no 2083 0.369090556892492 2983 3913060 SGTC_1974 st069448 26.9 µM -0.337255745539785 0.383025018616203 no 2084 0.367962058666773 3142 6323587 YNR016C ACC1 SGTC_2481 5478948 45.16 µM -0.33732239106088 0.383002470684406 no 2085 0.367936941103012 3142 77792 SGTC_3211 9128781 49.47 µM -0.337463921335737 0.382954588586738 no 2086 0.367883602621732 3095 17194361 SGTC_1573 oleylamine 1.06 µM -0.337669235072496 0.382885130639103 no 2087 0.367806230610723 2984 5356789 An amine of the fatty acid oleic acid. SGTC_155 k072-0202 43.6 µM -0.3385457546873 0.382588645110704 no 2088 0.367475976568881 3043 5857737 SGTC_1223 0764-0573 147 µM -0.338671894986002 0.382545983415344 no 2089 0.367428457633684 2992 1609797 SGTC_1336 1486-0901 104 µM -0.341169671736157 0.381701508779198 no 2090 0.366487926752881 3065 5006114 SGTC_2754 granisetron 64.02 µM -0.341602812567723 0.381555125109887 no 2091 0.3663249101428 3133 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1634 st006576 41 µM -0.343902910510909 0.380778071510178 no 2092 0.365459651479268 3195 3915356 SGTC_40 0327-0103 19.753 µM -0.346040759122842 0.380056262298742 no 2093 0.364656041704628 3023 409036 SGTC_118 0083-0097 135.343 µM -0.346791230554807 0.379802976930496 no 2094 0.364374082890688 3052 5207356 SGTC_2697 mebhydrolin 72.4 µM -0.34740542135787 0.379595724860925 no 2095 0.36414338051495 3187 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_671 0560-0003 407 µM -0.348708334741623 0.379156185353252 no 2096 0.363654143184594 3038 3238678 SGTC_657 3534-0529 86.7 µM -0.349205932956742 0.378988361138259 no 2097 0.363467356195555 3169 1049549 SGTC_2722 naftopidil 47.16 µM -0.349907386834888 0.378751821571282 no 2098 0.363204101583782 3141 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_795 0685-0265 78 µM -0.350296019065289 0.378620789162956 no 2099 0.363058276283278 3013 302754 SGTC_1457 k015-0032 57.3 µM -0.351033291736121 0.378372246451908 no 2100 0.362781686247562 2999 4302660 SGTC_57 miconazole 162.5 nM -0.351114451910579 0.378344889538382 no 2101 0.36275124313746 3058 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_337 1315-0038 354 µM -0.351186108339891 0.378320736588781 no 2102 0.362724365594884 3039 1626437 SGTC_653 0203-0016 55.2 µM -0.353444328404424 0.377559811313258 no 2103 0.361877679113707 3079 295302 SGTC_63 0099-0242 26.702 µM -0.354164013216944 0.377317407439192 no 2104 0.361607985619358 3161 3898502 YLR359W ADE13 SGTC_2761 levamisole 97.89 µM -0.357446724406339 0.376212340612368 no 2105 0.360378701470096 3187 26879 An alkaline phosphatase inhibitor. SGTC_965 1291-5240 308 µM -0.357490245464698 0.376197696807135 no 2106 0.36036241369994 3159 2834598 SGTC_1306 1185-0270 9.02 µM -0.359103316756479 0.375655062418101 no 2107 0.359758900232396 3139 1548076 SGTC_1434 4073-0095 163 µM -0.362622645462948 0.374472020993878 no 2108 0.358443395741407 3112 24133745 SGTC_259 usnic acid 108.925 µM -0.362861562484079 0.374391750418665 no 2109 0.358354150611932 3250 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_989 1501-0895 10.3 µM -0.364421098893642 0.373867916269273 no 2110 0.35777179122942 3171 2830112 SGTC_893 0958-0369 48.9 µM -0.366147602563661 0.373288270959819 no 2111 0.357127469182962 3171 6819948 SGTC_1975 st070967 30.8 µM -0.36644623126392 0.373188040308636 no 2112 0.35701606378918 3214 261391 SGTC_2186 6124449 200 µM -0.367403249785351 0.372866887936617 no 2113 0.356659123933512 3178 3834182 YLR033W RSC58 SGTC_1194 1488-0194 225 µM -0.368541360625922 0.372485080348984 no 2114 0.35623480531965 3018 1391452 SGTC_112 phenothiazine 287.218 µM -0.368587684909533 0.372469542366868 no 2115 0.356217538134802 3201 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1708 st033234 31.827 µM -0.369590517591794 0.372133225514377 no 2116 0.355843808735213 3173 674664 SGTC_2736 butenafine 14.65 µM -0.371171406136953 0.371603245998896 no 2117 0.355254934471439 3063 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_895 0964-0006 13.7 µM -0.371377577366131 0.371534146749113 no 2118 0.355178162000523 3190 6738897 SGTC_405 ebelactone b 50 µM -0.371789162705601 0.371396214383882 no 2119 0.355024916571843 3075 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1466 k213-0079 57.5 µM -0.37212918924788 0.371282275586429 no 2120 0.354898332292216 3064 3657981 SGTC_1151 3909-8316 15.3 µM -0.372348005773187 0.371208958769699 no 2121 0.354816880260992 3166 800431 SGTC_2210 7115885 190.385 µM -0.372467186011744 0.371169028122175 no 2122 0.354772519526738 3077 2927039 SGTC_304 1310-0298 97 µM -0.37499482079361 0.370322485995828 no 2123 0.353832159243425 3120 1550234 SGTC_1654 st012436 41.8 µM -0.375391237202369 0.370189777136569 no 2124 0.353684760456086 3162 4323132 SGTC_1876 myriocin 605 nM -0.377117899592732 0.369611920437011 no 2125 0.353042994822708 3247 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1393 3470-5649 58.2 µM -0.382100956386589 0.367945911150174 no 2126 0.351193241226249 3130 4108395 SGTC_232 clozapine 119 µM -0.382656793208031 0.367760228798475 no 2127 0.350987127225292 3107 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_621 3584-0052 32.1 µM -0.385394206900566 0.366846222431825 no 2128 0.349972686982868 3202 2273927 SGTC_1685 st024049 53.0905 µM -0.385515286264416 0.366805812126617 no 2129 0.349927841627872 3136 1941139 SGTC_292 k038-0015 474 µM -0.386039371058159 0.366630915561452 no 2130 0.349733755333842 3189 46368540 SGTC_1683 st010134 710 nM -0.386641115813867 0.366430136611905 no 2131 0.349510957357834 3054 3818134 SGTC_120 rhodamine 6G 52.259 µM -0.387939978272982 0.36599688111385 no 2132 0.349030226026149 3050 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1265 0819-1001 68.8 µM -0.388186797288169 0.365914570142462 no 2133 0.3489389014251 3160 3106768 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.388350543369149 0.365859966332642 no 2134 0.348878319164131 3268 23847180 SGTC_735 3076-0345 636 µM -0.388863939333825 0.365688783668211 no 2135 0.348688399517192 3243 2888990 SGTC_1728 st035614 33.7865 µM -0.389713442715628 0.365405590770993 no 2136 0.348374227544147 3130 15945546 SGTC_2148 5546263 113.568 µM -0.39052901540645 0.365133778128878 no 2137 0.348072702007509 3070 792097 SGTC_3131 9127911 49.47 µM -0.391016109457422 0.364971472577337 no 2138 0.34789266416081 3314 45595681 SGTC_507 nimesulide 162 µM -0.392099750424523 0.364610477282971 no 2139 0.34749225595747 3283 4495 A COX2 inhibitor. SGTC_886 0866-0150 153 µM -0.392404530432523 0.364508966974605 no 2140 0.347379669569076 3252 271463 SGTC_83 0170-0301 39.027 µM -0.394354608355278 0.363859697377188 no 2141 0.346659625655518 3158 3089716 SGTC_1100 amiodarone 5.07 µM -0.396239762126293 0.36323241531483 no 2142 0.345964080397265 3201 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_540 1187-0821 17.3 µM -0.40143346361633 0.361506119979313 no 2143 0.344050508039979 3122 847520 SGTC_1473 k844-0725 134 µM -0.406897212342149 0.359693104282398 no 2144 0.342041741745273 3178 54682906 SGTC_548 1436-0017 110 µM -0.406956925668048 0.359673307174016 no 2145 0.342019812484425 3258 9677137 SGTC_1348 1493-0373 93.8 µM -0.407483139354188 0.359498864756578 no 2146 0.341826587591782 3165 3010129 SGTC_26 0302-0163 425.158 µM -0.407636055500441 0.359448177792384 no 2147 0.341770444774058 3159 3100915 SGTC_1672 st016598 6.51 µM -0.408366726222009 0.359206017241966 no 2148 0.341502228998362 3131 4665860 YNL267W PIK1 SGTC_853 0419-0306 21 µM -0.408826077338351 0.359053806996559 no 2149 0.341333650614681 3099 762713 SGTC_3236 9132701 49.47 µM -0.409728291314665 0.358754915185542 no 2150 0.341002637085574 3195 24282524 SGTC_2297 7971671 152.32 µM -0.411405165215678 0.358199618409926 no 2151 0.340387733541867 3303 909016 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.412085808777908 0.3579743087756 no 2152 0.340138264944908 3481 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2276 7947513 42.08 µM -0.412883314704648 0.357710377779291 no 2153 0.339846053123738 3176 2105100 SGTC_249 wiskostatin 11.211 µM -0.413317105389388 0.357566845258271 no 2154 0.339687149529457 3243 2775510 A n-wasp and actin depolymerizer. SGTC_363 0455-0021 3.06 µM -0.415888793014554 0.356716340380528 no 2155 0.338745690282696 3111 4597466 SGTC_1808 st050063 61.5 µM -0.418342457363931 0.355905531443287 no 2156 0.337848375816429 3269 4011993 SGTC_1861 st057647 17.4 µM -0.418679246415875 0.355794290866193 no 2157 0.337725282520412 3307 688668 SGTC_3258 9138477 49.47 µM -0.419272193050288 0.355598471926091 no 2158 0.337508608171471 3181 4970355 SGTC_113 0099-0221 2.5 µM -0.420262889812717 0.355271382178854 no 2159 0.337146708314737 3305 89219 SGTC_1205 4161-2785 76 µM -0.420874747224243 0.355069423759928 no 2160 0.336923273066266 3222 3498106 SGTC_2164 5685496 200 µM -0.420926719561532 0.355052270901093 no 2161 0.336904296699418 3280 759046 SGTC_2790 5423970 71.43 µM -0.420989171148025 0.355031659877834 no 2162 0.33688149465245 3295 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_504 lovastatin 124 µM -0.421377957600793 0.354903357441945 no 2163 0.336739556148582 3176 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2948 9070189 9.45 µM -0.422868577267761 0.354411594393649 no 2164 0.336195575017572 3246 6473636 YDL196W YDL196W SGTC_1923 st058458 19.1 µM -0.423169492891278 0.354312350197535 no 2165 0.336085801554396 3346 3534982 SGTC_1012 4112-3522 18 µM -0.423767906345089 0.354115018422223 no 2166 0.335867542977126 3290 3112398 SGTC_457 grayanotoxin iii 135 µM -0.425046527081016 0.353693514002816 no 2167 0.335401378795096 3242 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_485 niflumic acid 177 µM -0.427036870705456 0.353037743125402 no 2168 0.334676236325377 3264 4488 A COX2 inhibitor. SGTC_1317 1273-0028 910 nM -0.427241538669662 0.352970334603615 no 2169 0.334601704479573 3162 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1169 aniline yellow 25.8 µM -0.428966823082939 0.352402286256026 no 2170 0.333973684510534 3167 6051 A DNA damaging agent. SGTC_2255 7941087 197.44 µM -0.429887436730737 0.352099309591941 no 2171 0.333638762378133 3292 935561 SGTC_1695 st026914 34.495 µM -0.433328671224562 0.350967621701061 no 2172 0.332388005862622 3153 3289191 SGTC_1305 1181-0477 144 µM -0.433381365953062 0.35095030270029 no 2173 0.332368867810656 3288 6252086 SGTC_1562 morin hydrate 59.1 µM -0.433554064775939 0.350893544524345 no 2174 0.332306148868812 3317 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2445 5742597 35.57 µM -0.435542734187329 0.35024020019675 no 2175 0.331584263589051 3127 1774255 SGTC_2750 bromebric acid 70.15 µM -0.436215317140826 0.350019334370134 no 2176 0.331340257874865 3300 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2420 aureobasidin a 50 nM -0.437108273436288 0.349726179743556 no 2177 0.331016413745897 3380 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3199 9111318 49.47 µM -0.438219021320395 0.349361649874836 no 2178 0.330613760593229 3231 8548020 SGTC_1382 3002-2117 298 µM -0.438843753921689 0.349156683536107 no 2179 0.33038737713372 3327 1497314 SGTC_1664 st014217 9.02 µM -0.439504540066597 0.348939936389823 no 2180 0.330147996536751 3304 3982782 SGTC_477 mead ethanolamide 10 µM -0.439555300984738 0.348923288132322 no 2181 0.330129610437167 3191 16061185 SGTC_2221 6807166 181.081 µM -0.439883194702947 0.348815754551079 no 2182 0.330010854020001 3225 674925 SGTC_1344 1488-0097 29.1 µM -0.439920049624244 0.348803668644616 no 2183 0.329997506989746 3279 747966 SGTC_2262 9014885 67.46 µM -0.440035422355343 0.348765835231044 no 2184 0.329955726090074 3144 6457424 SGTC_1590 st077108 57.8 µM -0.441798075847869 0.348188007165792 no 2185 0.329317665535772 3268 5489485 SGTC_2074 5212007 75.395 µM -0.442496746350943 0.347959068387847 no 2186 0.329064892111394 3276 758611 SGTC_717 1532-0246 73.2 µM -0.442561868188911 0.347937732232438 no 2187 0.329041335528298 3227 9561992 SGTC_3301 9125354 19.7965 µM -0.442663156888942 0.347904547525062 no 2188 0.329004697621701 3214 41905162 SGTC_2066 5222451 176 µM -0.442723134795132 0.347884897814439 no 2189 0.328983003331095 3180 2281147 SGTC_1270 0831-1170 17.3 µM -0.444743916929991 0.347223096678099 no 2190 0.328252413993591 3258 6764716 SGTC_668 1682-0499 62.6 µM -0.446217769387808 0.346740707140015 no 2191 0.327719974228111 3244 682214 SGTC_1505 k297-0037 20.6 µM -0.447621662314629 0.34628144616747 no 2192 0.327213133350432 3181 4089396 SGTC_1292 0kpi-0043 232 µM -0.447638104266513 0.346276068784854 no 2193 0.327207199274482 3234 3333905 SGTC_955 1216-0110 33 µM -0.448545078629451 0.345979488518052 no 2194 0.32687993023407 3210 3619719 SGTC_89 0302-0250 142.109 µM -0.448633758451981 0.345950495316985 no 2195 0.326847938498154 3277 4203518 YLR208W SEC13 SGTC_156 3474-0145 5.642 µM -0.449354258863256 0.345714966617839 no 2196 0.326588061190531 3315 2265471 SGTC_1281 0884-0031 11.8 µM -0.449392029298937 0.345702621259811 no 2197 0.326574440090992 3211 1548255 SGTC_330 1488-0319 80.1 µM -0.449993199831839 0.345506149317016 no 2198 0.326357671935642 3245 6846614 SGTC_3020 9089140 49.47 µM -0.451313702399537 0.345074734557105 no 2199 0.325881735256382 3306 17217859 SGTC_1209 2323-2347 50.3 µM -0.452117947379472 0.344812082309173 no 2200 0.325592007481071 3296 5412760 SGTC_1522 st012842 45.6 µM -0.452409952115305 0.344716737200933 no 2201 0.325486839368219 3132 3491067 YOR116C RPO31 SGTC_1610 st001799 48.1 µM -0.452904325044381 0.344555337508458 no 2202 0.325308818217822 3127 621897 SGTC_2290 7904846 200 µM -0.453538044976687 0.344348486087964 no 2203 0.325080677221689 3252 2962154 SGTC_2748 diazoxide 86.69 µM -0.453732029043535 0.344285177388647 no 2204 0.325010855502943 3232 3019 A potassium channel activatior. SGTC_719 2810-4230 27.3 µM -0.454233862232468 0.344121419203105 no 2205 0.324830256526667 3249 721079 SGTC_2593 nobiletin 86.24 µM -0.454462741819447 0.344046740928905 no 2206 0.324747901349747 3234 72344 An anti-infammatory. SGTC_2851 9015922 71.43 µM -0.454846446814778 0.343921560244116 no 2207 0.3246098563002 3337 2996893 SGTC_986 1493-0483 84 µM -0.455453601164984 0.343723515949147 no 2208 0.324391470390692 3305 40079 SGTC_1825 st052143 62.6 µM -0.457850294116274 0.342942171190043 no 2209 0.3235299998105 3345 674173 SGTC_1630 st005209 31.3 µM -0.458180640998033 0.342834527514498 no 2210 0.323411333476576 3336 3367314 SGTC_1755 st041960 45.185 µM -0.460669816232976 0.342023839444581 no 2211 0.322517756755746 3316 2257073 SGTC_3047 9092122 49.47 µM -0.461182223086409 0.341857046206273 no 2212 0.322333937309495 3257 17173831 SGTC_2456 5770359 74.46 µM -0.461555313458045 0.341735621204712 no 2213 0.32220012320384 3345 3118787 SGTC_2385 9074692 200 µM -0.461918490203853 0.341617438391315 no 2214 0.322069886890129 3236 17046906 SGTC_2001 4023502 57.655 µM -0.462218911280824 0.341519688885746 no 2215 0.321962171464444 3280 108941 YCR052W RSC6 SGTC_670 4204-0025 119 µM -0.463313205509502 0.34116372282049 no 2216 0.321569940794834 3297 719039 SGTC_1077 5-fluorocytosine 377 nM -0.465323980693022 0.340510000639983 no 2217 0.320849732083508 3286 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_27 0485-0001 32.618 µM -0.465886306477495 0.34032726876838 no 2218 0.32064844166142 3276 2054479 SGTC_66 0109-0187 42.4 µM -0.466690453658669 0.340066020407545 no 2219 0.320360680356939 3330 759417 SGTC_2438 5259590 200 µM -0.469998747661104 0.338992042859936 no 2220 0.319177956149857 3293 1201127 SGTC_1052 3253-3998 198 µM -0.470278053062618 0.33890143115706 no 2221 0.319078187678139 3212 5450317 SGTC_1784 st039334 36.3 µM -0.470525421480366 0.338821188169408 no 2222 0.318989838105399 3410 3496984 SGTC_736 0958-0254 92.6 µM -0.470739421668382 0.3387517752871 no 2223 0.318913414553409 3351 6812352 SGTC_103 0844-0104 51.839 µM -0.470777966149986 0.338739273620335 no 2224 0.318899650401376 3333 5375804 SGTC_996 3970-0799 1.8 µM -0.471269884443467 0.338579738537544 no 2225 0.31872400936919 3270 6615648 YGL040C HEM2 SGTC_997 3996-0078 137 µM -0.471789275047043 0.338411325283452 no 2226 0.318538603447275 3260 735687 SGTC_550 4123-0385 25.7 µM -0.472174494570186 0.338286438092404 no 2227 0.318401121670749 3239 5731123 SGTC_1731 st035964 63 µM -0.472766326528564 0.338094602336912 no 2228 0.318189950286473 3220 6739575 SGTC_732 3970-1727 52.7 µM -0.474097878226156 0.3376631483719 no 2229 0.317715055791851 3335 1275699 SGTC_1464 k208-0027 110 µM -0.479245627292619 0.335997167284661 no 2230 0.315881949090923 3416 X1464 SGTC_1168 k815-0004 80.5 µM -0.479426724793862 0.335938616559355 no 2231 0.315817542533708 3188 642433 SGTC_2172 5754775 163.918 µM -0.480391084728826 0.335626895934415 no 2232 0.315474666227105 3218 2263357 SGTC_1867 st057372 64 µM -0.480923672282112 0.335454790283935 no 2233 0.315285373809342 3321 688837 SGTC_1423 4048-0112 5.59 µM -0.481012341916679 0.335426140045675 no 2234 0.315253863529186 3330 X1423 SGTC_1185 1319-0113 81.3 µM -0.482386488748127 0.334982258904897 no 2235 0.314765708726433 3338 4672763 SGTC_1403 3909-7815 62.9 µM -0.484062694021411 0.334441117881725 no 2236 0.3141706880675 3234 6615483 SGTC_583 1488-1091 88.9 µM -0.484066880280681 0.334439766832437 no 2237 0.314169202629517 3358 4303273 SGTC_1773 st048542 73.5835 µM -0.484569553735157 0.334277552478636 no 2238 0.313990857579966 3229 3237138 SGTC_2875 9039966 71.43 µM -0.486612474995413 0.333618613862694 no 2239 0.313266490652333 3289 6463691 SGTC_2749 bexarotene 57.39 µM -0.487146288320732 0.333446518287973 no 2240 0.313077332794821 3290 82146 An retinoic acid receptor inhibitor. SGTC_2925 9010536 32.5 µM -0.487362447881897 0.333376840778448 no 2241 0.313000750194602 3272 2994177 SGTC_751 0833-0568 350 µM -0.48885773155063 0.332895004181393 no 2242 0.312471211161735 3323 6954252 SGTC_1587 estradiol valerate 56.1 µM -0.490548002597036 0.332350667432183 no 2243 0.311873085358675 3386 13791 A steroid. SGTC_590 k048-0076 22.4 µM -0.490787100855685 0.332273696473062 no 2244 0.311788517122826 3350 6832814 SGTC_1159 4092-0538 61.2 µM -0.491073227066187 0.332181595485879 no 2245 0.31168732830447 3312 717301 SGTC_399 oxolinic acid 75 µM -0.497763635258119 0.330030923634003 no 2246 0.309325324915354 3264 4628 A DNA gyrase inhibitor. SGTC_2357 9067248 200 µM -0.498102652742259 0.329922093059579 no 2247 0.309205845459753 3356 9150235 SGTC_480 am 92016 50 µM -0.500320363610681 0.329210524283595 no 2248 0.308424758841522 3330 2129 K+ channel blocker. SGTC_538 2922-0838 53.3 µM -0.503172548169939 0.328296289024645 no 2249 0.307421481810907 3428 777039 SGTC_2492 derrusnin 100 µM -0.50385998120945 0.328076093636796 no 2250 0.307179887102045 3314 1715307 Part of coumarin class of compounds. SGTC_826 1683-5028 118 µM -0.503956663706318 0.328045129534142 no 2251 0.307145915258537 3348 722377 SGTC_1358 1509-0022 2.48 µM -0.505127534326807 0.327670233520614 no 2252 0.30673463168747 3354 3258434 SGTC_1998 st075797 76.8 µM -0.505712364950667 0.327483044131599 no 2253 0.306529293345581 3397 24208315 SGTC_1837 st055472 66.5 µM -0.508567268030431 0.326569885588912 no 2254 0.30552778850165 3455 676091 SGTC_3042 9091578 49.47 µM -0.508782767475432 0.326500998821918 no 2255 0.305452249835269 3366 25236497 SGTC_1806 st050005 60.3 µM -0.508834467942802 0.326484473078934 no 2256 0.305434128587068 3309 5194765 SGTC_416 estradiol valerate 100 µM -0.509587311109976 0.326243869893355 no 2257 0.305170307674075 3382 13791 A steroid. SGTC_162 k030-0015 37.8 µM -0.510015973858682 0.326106904700874 no 2258 0.305020135407346 3341 1809920 YMR134W ERG29 SGTC_1460 k062-0059 9.15 µM -0.510493175655869 0.325954458028384 no 2259 0.304852997201417 3284 1373085 SGTC_423 5-fluorouracil 457 µM -0.510759160923475 0.325869499117696 no 2260 0.304759854490306 3201 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2516 gossypol 71.55 µM -0.511258590261837 0.325709999776039 no 2261 0.304584998530707 3430 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3182 9108849 49.47 µM -0.511854818772802 0.325519628117397 no 2262 0.304376310528097 3396 17133045 SGTC_782 0083-0095 30.5 µM -0.512147476630948 0.32542620112551 no 2263 0.304273899635128 3368 3591729 An indicator and reagent. SGTC_2375 9072683 200 µM -0.515069395033513 0.32449402117056 no 2264 0.303252264129595 3453 16798029 SGTC_1570 verbenone 133 µM -0.515072061095424 0.324493171117317 no 2265 0.303251332653746 3431 29025 A natural terpanoid with antifungal properties. SGTC_599 1935-0052 86.5 µM -0.515152186164476 0.324467624284811 no 2266 0.303223338939502 3274 9557311 SGTC_2479 5617353 43.85 µM -0.518335865393758 0.323453219250334 no 2267 0.302111976726879 3439 2731746 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.520222879591436 0.322852584414666 no 2268 0.301454120179557 3285 23665772 A membrane-active detergent. SGTC_47 0149-0135 24.25 µM -0.521048103666117 0.322590061404949 no 2269 0.301166630850372 3299 5239155 SGTC_1968 st069590 43.6 µM -0.521823069963766 0.322343607064213 no 2270 0.300896762714381 3381 6384066 SGTC_990 3985-0011 41.3 µM -0.521873475400649 0.322327579858741 no 2271 0.300879213701525 3320 5399565 YGL099W LSG1 SGTC_2277 7947813 106.88 µM -0.521918082228632 0.3223133966881 no 2272 0.300863683900794 3478 1246798 SGTC_1936 st074407 74.3 µM -0.523069067230167 0.321947519417833 no 2273 0.300463095272288 3304 809813 SGTC_1553 gossypol 38.6 µM -0.523416221951209 0.321837199075392 no 2274 0.300342318909613 3352 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2125 5246583 200 µM -0.523860010358439 0.321696192927185 no 2275 0.300187955301503 3480 835267 SGTC_1967 st070177 51.4 µM -0.524053036369757 0.321634870238073 no 2276 0.300120825961923 3448 5729214 SGTC_1907 st060210 83.7 µM -0.524723110114637 0.321422031345711 no 2277 0.299887844753244 3461 688793 SGTC_643 k048-0106 28.4 µM -0.527319643471307 0.320597835597105 no 2278 0.298985817684623 3406 6763920 SGTC_609 0986-0026 86.3 µM -0.527724098755405 0.32046953220882 no 2279 0.298845422248628 3361 2848610 SGTC_2393 9031399 185.94 µM -0.52780660732181 0.320443361050514 no 2280 0.298816785366962 3458 1526623 YDL150W RPC53 SGTC_1050 3232-1156 69.3 µM -0.529787770449066 0.31981521789164 no 2281 0.298129542667116 3340 700529 SGTC_537 1334-0398 209 µM -0.533046886794114 0.318783013714642 no 2282 0.297000562114774 3442 5846986 SGTC_1424 4048-1941 275 µM -0.533262297520388 0.3187148397485 no 2283 0.296926011289119 3468 X1424 SGTC_135 0933-0004 26.348 µM -0.533343548394051 0.318689126771334 no 2284 0.29689789365195 3421 21230617 YGL099W LSG1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.533363552290244 0.318682796392072 no 2285 0.296890971300436 3411 3256 An antibiotic and ribosome inhibitor. SGTC_2182 6325192 200 µM -0.536017296407298 0.317843469388146 no 2286 0.295973298290828 3410 736248 SGTC_1234 0326-0494 15.5 µM -0.536967331809298 0.317543218955218 no 2287 0.295645089918677 3469 1547813 SGTC_880 0833-0487 87.2 µM -0.538447190311213 0.317075761596954 no 2288 0.295134177283112 3407 76075 SGTC_8 0354-0001 70 µM -0.541731839827651 0.316039250555729 no 2289 0.294001626113333 3443 4993152 SGTC_64 000l-0018 272.079 µM -0.542279531729125 0.315866560006273 no 2290 0.293812976899039 3387 6811119 SGTC_924 2046-0044 21.3 µM -0.542751734565439 0.31571770386605 no 2291 0.293650374413151 3422 3623589 SGTC_2975 9084847 53.72 µM -0.543414802650828 0.315508730255624 no 2292 0.293422118046282 3391 27211724 SGTC_3209 9113616 49.47 µM -0.543775874254317 0.315394959147444 no 2293 0.29329785634905 3494 16649353 SGTC_830 4076-0286 57.8 µM -0.543782764547579 0.315392788234912 no 2294 0.293295485312695 3449 6866659 SGTC_1945 st075991 56.6 µM -0.543818548216135 0.315381514040133 no 2295 0.293283171846285 3358 1084980 SGTC_3174 9107204 49.47 µM -0.54384600787748 0.315372862568331 no 2296 0.293273722904441 3456 3938802 SGTC_157 1348-1695 65.819 µM -0.544306435053658 0.315227814945419 no 2297 0.29311530972244 3438 5380510 SGTC_1983 st071813 46.9 µM -0.544848706100413 0.315057020703565 no 2298 0.292928788494435 3399 11838595 SGTC_1186 1319-0216 26 µM -0.545750232352216 0.314773162583438 no 2299 0.292618818701748 3483 4565136 SGTC_1279 0874-0590 65.2 µM -0.546327327432492 0.314591513566663 no 2300 0.292420477394782 3386 3523074 SGTC_1033 k072-0102 21.3 µM -0.548112117728132 0.314030009135931 no 2301 0.291807460272617 3453 5965931 SGTC_3338 9144300 39.5675 µM -0.549618438694581 0.313556447345639 no 2302 0.291290554621575 3370 4901274 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.54998211482922 0.313442159726675 no 2303 0.291165820427929 3379 689007 SGTC_980 1473-0395 201 µM -0.550366619559135 0.313321346061811 no 2304 0.291033969541514 3381 768876 SGTC_1378 2093-0007 380 nM -0.551185712960949 0.313064048856644 no 2305 0.290753186472236 3419 3618014 SGTC_10 0279-0212 42.575 µM -0.552313131036246 0.312710048204224 no 2306 0.290366917816817 3434 39851 YBR002C RER2 SGTC_852 0418-0143 439 µM -0.552991115734946 0.312497249318072 no 2307 0.290134746858835 3467 5369229 SGTC_3244 9134489 49.47 µM -0.553865609835603 0.312222864385586 no 2308 0.289835411209502 3423 16584271 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.5548070665168 0.311927585370628 no 2309 0.289513316577708 3310 4000243 SGTC_1301 naphtanilide LB 4.81 µM -0.554911496971575 0.311894839184193 no 2310 0.289477598804976 3491 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2528 xanthyletin 44.79 µM -0.555195595467597 0.31180576213762 no 2311 0.289380440637808 3390 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2047 4141938 200 µM -0.557597865816328 0.311052987998836 no 2312 0.288559507071909 3381 3807862 SGTC_2567 aureobasidin a 60 nM -0.557931115123589 0.310948623487779 no 2313 0.28844571171385 3507 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2351 9026858 72.31 µM -0.557975698757674 0.310934662273536 no 2314 0.288430489248694 3366 1409300 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.558442044066657 0.310788644130493 no 2315 0.288271284794025 3431 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2960 9079389 5.97 µM -0.559172020498218 0.310560139839369 no 2316 0.288022163214135 3469 16457355 SGTC_1134 3477-0009 42.5 µM -0.560231803980108 0.310228526221192 no 2317 0.287660668209433 3546 3973534 SGTC_2183 6420625 130.508 µM -0.560901185308726 0.310019151611701 no 2318 0.28743245097631 3485 2897619 SGTC_2263 7948595 193.29 µM -0.56152500782468 0.309824082704414 no 2319 0.287219843573821 3438 2971371 SGTC_325 2810-4341 181 µM -0.561862461411312 0.309718583489975 no 2320 0.28710486572193 3482 774970 SGTC_2032 5185112 25.99 µM -0.563250379846329 0.309284838891328 no 2321 0.286632200707109 3376 5718189 SGTC_868 0527-0199 213 µM -0.564794079573155 0.308802722406269 no 2322 0.286106917218313 3355 2849450 SGTC_3349 9149703 23.001 µM -0.565530118662572 0.308572964191172 no 2323 0.285856622128702 3465 4910494 SGTC_154 3389-1638 511.116 µM -0.567324479641948 0.308013159732203 no 2324 0.285246874181626 3395 5238686 SGTC_2053 5265679 138 µM -0.56754884586168 0.307943193368209 no 2325 0.285170675138241 3412 764595 SGTC_650 1328-0195 38 µM -0.569177913551579 0.307435394370429 no 2326 0.284617703846215 3466 2780821 SGTC_509 pifithrin 175 µM -0.572296286624798 0.306464391254518 no 2327 0.28356063251435 3525 4817 A p53 inhibitor. SGTC_2083 5306046 65.942 µM -0.573572639355853 0.306067349907599 no 2328 0.283128515537015 3458 539837 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.574666430973881 0.305727279911789 no 2329 0.282758457333241 3483 17037758 SGTC_484 loperamide 105 µM -0.57543477738652 0.305488493979886 no 2330 0.282498644749007 3423 3955 An opioid-receptor agonist. SGTC_281 1672-3440 14.9 µM -0.575763584784969 0.305386332812541 no 2331 0.282387495218166 3473 6833000 SGTC_1257 0669-0121 16 µM -0.575892283720215 0.305346349902318 no 2332 0.282343995763448 3469 4307855 SGTC_1114 scopoletin 1.73284 µM -0.57599215204977 0.30531532539912 no 2333 0.282310243098984 3503 5280460 A coumarin with genotoxic properties. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.576765719112225 0.305075061023356 no 2334 0.282048865140211 3413 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2240 6690706 185.951 µM -0.579030148579291 0.304372228562097 no 2335 0.28128441528715 3394 805876 SGTC_2365 9042475 200 µM -0.579215900312121 0.304314607037619 no 2336 0.28122175168698 3481 6464479 SGTC_184 1494-0393 24.714 µM -0.581315927431888 0.303663501704797 no 2337 0.280513773971906 3430 3090647 SGTC_2627 acetyl isogambogic acid 100 µM -0.583620859340816 0.302949583155513 no 2338 0.279737711501311 3451 6857789 A caspase activator and apoptosis inducer. SGTC_1375 2910-0797 186 µM -0.584886956562487 0.302557748205584 no 2339 0.279311864767201 3427 742508 SGTC_1579 chlormadinone acetate 49.4 µM -0.586233776534254 0.302141180506616 no 2340 0.278859213290654 3520 45114258 A steroidal progestin. SGTC_1779 st039427 55 µM -0.587218499426722 0.301836771476376 no 2341 0.278528484745393 3547 1124498 SGTC_1762 st045503 25.4615 µM -0.587361740807428 0.301792502515022 no 2342 0.278480391689054 3477 4645554 SGTC_2717 st081029 62.2815 µM -0.588495179964324 0.301442314423215 no 2343 0.278099984098043 3491 5292846 SGTC_299 1273-0059 1.44 µM -0.588680958506676 0.30138493361424 no 2344 0.278037656841173 3480 2848077 SGTC_557 1315-0110 16.2 µM -0.590622494539442 0.300785552207267 no 2345 0.277386694695022 3487 6833801 SGTC_1472 k841-0093 193 µM -0.59178269349903 0.300427638224883 no 2346 0.27699805683341 3562 X1472 SGTC_3237 9133362 49.47 µM -0.59231904193222 0.300262243210404 no 2347 0.27681848355591 3482 43845137 SGTC_2187 6125751 200 µM -0.593238850394122 0.29997869559895 no 2348 0.276510657934249 3483 874498 SGTC_2442 5158906 48.48 µM -0.593606610777884 0.2998653607189 no 2349 0.276387629218491 3504 1893835 SGTC_596 1155-0152 116 µM -0.594457264020696 0.299603284209175 no 2350 0.276103158862509 3509 280313 SGTC_1256 0570-0116 285 µM -0.594936439940329 0.2994557013167 no 2351 0.275942979038836 3459 410638 SGTC_1583 clindamycin 39.6 µM -0.595166670856234 0.299384803500112 no 2352 0.275866033254368 3445 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1391 3442-0225 151 µM -0.595904513606296 0.299157641879382 no 2353 0.275619508883196 3467 5227075 SGTC_1366 1683-0113 21.9 µM -0.596059769677391 0.29910985274153 no 2354 0.275567649290047 3492 708623 SGTC_1605 st000082 49.1 µM -0.596636527991724 0.298932351988641 no 2355 0.275375038944457 3509 1114022 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.597947481104379 0.298529076565632 no 2356 0.274937488382222 3541 165521 SGTC_1237 0330-0133 46.1 µM -0.600682134513861 0.297688640049478 no 2357 0.274025860274422 3475 X1237 YHR072W ERG7 SGTC_41 0478-0632 82.643 µM -0.600977822337723 0.297597831512009 no 2358 0.273927378905562 3550 3750424 SGTC_144 4161-2749 112.381 µM -0.601921715866238 0.297308037485727 no 2359 0.273613124174352 3460 797501 YMR168C CEP3 SGTC_976 1348-1067 47.6 µM -0.602446852266587 0.297146866042392 no 2360 0.273438365408426 3551 5310671 YGL099W LSG1 SGTC_1662 st014054 52 µM -0.602543405717831 0.297117236833925 no 2361 0.273406239653897 3510 2838777 SGTC_2013 4024628 200 µM -0.60297950928725 0.296983427237767 no 2362 0.273261160347423 3556 5230760 SGTC_131 0141-0277 33.849 µM -0.603644506251297 0.29677943939855 no 2363 0.273040008127795 3515 1547771 SGTC_1898 st060199 18.6 µM -0.60447252567371 0.29652553410838 no 2364 0.272764765025796 3527 688866 SGTC_2352 9027995 87.8 µM -0.605119823459036 0.296327114954136 no 2365 0.272549691770268 3473 2997347 SGTC_2661 dactinomycin 12.96 µM -0.607949779440153 0.295460351360542 no 2366 0.271610391260869 3538 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1741 st038134 10.228 µM -0.608280071078682 0.295359265129094 no 2367 0.271500868148366 3609 1272587 SGTC_2363 9053361 176 µM -0.609151262754767 0.295092712032787 no 2368 0.271212090767646 3599 6469797 YMR079W SEC14 SGTC_3318 9139014 38.6185 µM -0.610630833197948 0.294640271104218 no 2369 0.270722002776943 3530 16643984 SGTC_3264 9137442 49.47 µM -0.611942704328537 0.294239379143478 no 2370 0.270287833105341 3598 17015726 SGTC_1568 digitonin 820 nM -0.61331279854033 0.293820964108479 no 2371 0.269834766194234 3574 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1843 st055809 45.5 µM -0.613446879208181 0.293780031812263 no 2372 0.269790448426655 3542 16413835 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.613693291290519 0.29370481373699 no 2373 0.269709011191205 3516 97141 SGTC_738 1315-0003 72.4 µM -0.613769806193096 0.293681459132217 no 2374 0.269683726129208 3548 6251474 SGTC_1288 0973-0013 65.5 µM -0.61383179836146 0.293662537924562 no 2375 0.269663241110697 3550 4315430 SGTC_2195 6536160 144.242 µM -0.614713096645959 0.293393609711964 no 2376 0.269372104598774 3424 3834386 SGTC_2192 5915882 198.485 µM -0.6157677135611 0.293071943367033 no 2377 0.269023919606225 3499 2876149 SGTC_3342 9147791 14.508 µM -0.617203928494395 0.292634149931234 no 2378 0.268550112427423 3521 1838168 SGTC_1407 3909-7909 12.3 µM -0.619174158329489 0.292034070445909 no 2379 0.267900816879567 3560 4411780 SGTC_625 k213-0058 121 µM -0.619179049705324 0.292032581376334 no 2380 0.267899205895436 3599 3655420 SGTC_1430 4049-0248 69.1 µM -0.619674840565382 0.291881667318133 no 2381 0.267735941527687 3584 22774488 SGTC_1494 4358-1428 177 µM -0.620034329723718 0.291772264934817 no 2382 0.267617592794824 3579 1564571 SGTC_792 4534-1957 155 µM -0.620568718471984 0.291609671144325 no 2383 0.267441713482184 3490 1717904 SGTC_2304 7443016 91.4 µM -0.620589391105005 0.291603382111861 no 2384 0.267434910826795 3522 939854 SGTC_3331 9141060 1.957 µM -0.620659906653069 0.291581930333782 no 2385 0.267411707232 3501 4906567 YPR165W RHO1 SGTC_487 nimodipine 119 µM -0.621391159148034 0.291359516882182 no 2386 0.267171143775458 3467 4497 L-type voltage-gated calcium channels inhibitor SGTC_1157 4092-0394 27.6 µM -0.62183194250647 0.29122548906488 no 2387 0.267026190057381 3638 3659885 SGTC_2128 5255449 168.493 µM -0.622021973813883 0.291167715633958 no 2388 0.266963709606015 3540 736008 SGTC_2789 5281112 71.43 µM -0.622236442268792 0.291102519235849 no 2389 0.266893203328116 3527 765948 SGTC_429 1112-0049 25.5 µM -0.623177379198392 0.290816563843608 no 2390 0.266583982520844 3481 2836170 SGTC_1793 st048256 72.231 µM -0.626133847017868 0.289918934270195 no 2391 0.265613576601273 3514 672022 SGTC_1770 st043884 66.3 µM -0.626850790608376 0.289701454957579 no 2392 0.265378523299567 3565 670149 SGTC_570 0987-0065 62.6 µM -0.62816029374821 0.289304425028162 no 2393 0.264949469257822 3451 3104428 SGTC_2807 7945238 51.95 µM -0.628402590201919 0.289230990900458 no 2394 0.264870120350865 3565 17148797 SGTC_1850 st056238 17 µM -0.63084810018717 0.288490307620417 no 2395 0.264069924715627 3579 5393177 SGTC_3307 9126885 69.2785 µM -0.631170553977964 0.288392711243278 no 2396 0.263964506555302 3539 24824909 SGTC_1997 st073024 93.8 µM -0.631938413812044 0.288160367486757 no 2397 0.263713560467169 3563 686268 SGTC_2101 5377231 179.231 µM -0.632315982468934 0.288046152836175 no 2398 0.263590211004031 3559 2844213 SGTC_2784 7567673 72.73 µM -0.633405979476991 0.28771654829266 no 2399 0.263234280621579 3595 3471247 SGTC_2218 6965428 192.983 µM -0.633718985108513 0.287621931365824 no 2400 0.263132116358803 3544 675684 SGTC_426 0988-0037 14.6 µM -0.633726494401603 0.287619661599354 no 2401 0.263129665593012 3596 5383008 SGTC_1419 3993-2473 62.6 µM -0.633744188824262 0.287614313298872 no 2402 0.263123890809831 3586 704026 SGTC_1031 k035-0009 16 µM -0.633935942610715 0.287556356984888 no 2403 0.2630613138574 3596 5180959 SGTC_2950 9072895 21.46 µM -0.635037614562876 0.287223490951227 no 2404 0.262701941534639 3543 17332245 SGTC_2909 7941780 10.49 µM -0.635277342702549 0.287151082163321 no 2405 0.262623773993693 3584 1243215 SGTC_3019 9081971 49.47 µM -0.638306655434003 0.286236837521551 no 2406 0.261637040224242 3625 16451803 SGTC_633 0437-0093 97.7 µM -0.638744223417084 0.286104894123038 no 2407 0.261494669245492 3579 2831118 SGTC_365 0121-0052 13.6 µM -0.640431028514303 0.285596528779121 no 2408 0.26094620791608 3585 3101739 SGTC_338 4055-0136 114 µM -0.640440459464171 0.285593687710547 no 2409 0.260943143125271 3545 2900563 SGTC_2488 5268135 45.7 µM -0.640636379891268 0.285534669829588 no 2410 0.260879478738751 3569 1270356 YLR208W SEC13 SGTC_23 0213-0011 39.996 µM -0.641614164896806 0.28524021462445 no 2411 0.260561866758133 3616 627608 SGTC_2248 tofa 1.1 µM -0.643327586196372 0.284724575314046 no 2412 0.260005779960664 3537 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1828 st055811 49 µM -0.644013466744142 0.28451829026736 no 2413 0.259783350712348 3569 5877589 SGTC_1502 4534-4282 27.7 µM -0.645770612570703 0.283990138020525 no 2414 0.259213961287366 3572 3278949 SGTC_1278 0874-0585 172 µM -0.646963687532592 0.283631798371197 no 2415 0.258827722638074 3576 766306 SGTC_2770 toltrazuril 17.5 µM -0.647846857441195 0.283366678187738 no 2416 0.258542002652853 3594 68591 Kills coccidiodes. SGTC_2687 chenodiol 100 µM -0.648659380716609 0.28312287052105 no 2417 0.258279282355495 3605 5702181 A cholesterol synthesis inhibitor. SGTC_672 1441-0018 53.7 µM -0.651555318705909 0.282254728155943 no 2418 0.25734403988471 3573 251141 SGTC_712 r015-0009 80.6 µM -0.653024463405408 0.281814799266244 no 2419 0.256870253745156 3578 6813872 YLR060W FRS1 SGTC_1909 st060837 51.5 µM -0.653583920890078 0.281647359115965 no 2420 0.256689953081262 3554 678937 SGTC_39 0986-0283 58.349 µM -0.655442928498479 0.281091321126361 no 2421 0.256091310005674 3642 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1249 0481-0015 10.2 µM -0.656034599410473 0.280914460865574 no 2422 0.25590093127954 3567 4227577 SGTC_1920 st075728 45.7 µM -0.656285973668458 0.280839337209281 no 2423 0.255820070314347 3622 3400306 SGTC_860 0443-0016 25.1 µM -0.657052292355546 0.280610381427003 no 2424 0.255573646616944 3618 5337942 SGTC_939 1165-0479 45.3 µM -0.658021358341575 0.280320979484258 no 2425 0.255262203468411 3560 1377347 SGTC_3112 9123419 49.47 µM -0.65902053206912 0.280022737598381 no 2426 0.254941292030542 3653 17015854 SGTC_1527 coumarin 137 µM -0.659459952753549 0.279891624285842 no 2427 0.254800227161778 3631 323 A hepatotoxic, DNA x-linker. SGTC_964 1287-0107 19.4 µM -0.660764185553493 0.279502645781179 no 2428 0.254381777036025 3626 51516812 YPR165W RHO1 SGTC_511 blebbistatin 171 µM -0.660855706149098 0.279475360249432 no 2429 0.254352427092859 3661 3476986 A myosin inhibitor. SGTC_3082 9117008 49.47 µM -0.661456162968422 0.279296374891058 no 2430 0.254159909295262 3612 41448529 SGTC_912 3474-0017 2.18 µM -0.66226492096143 0.279055386775393 no 2431 0.253900727042746 3647 3360550 SGTC_674 0498-0004 451 µM -0.662363550660901 0.279026004698442 no 2432 0.253869128726967 3578 4231473 SGTC_3293 9120939 62.045 µM -0.662643559549447 0.278942597428712 no 2433 0.253779432623172 3622 934087 SGTC_1956 st077085 54 µM -0.665978401332285 0.27795016943663 no 2434 0.252712452967429 3619 24208685 SGTC_1781 st038725 66.3 µM -0.666222843655732 0.277877492773036 no 2435 0.252634336894819 3638 4270275 YIL048W NEO1 SGTC_947 3447-0010 211 µM -0.666677311241933 0.277742396856135 no 2436 0.25248913717065 3643 748350 SGTC_449 xestospongin c 11.1929 µM -0.666825120677525 0.277698465649845 no 2437 0.252441922402837 3589 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2041 5107442 45.335 µM -0.668334561208419 0.277250031430421 no 2438 0.251960028320379 3640 793005 SGTC_3291 9121177 71.43 µM -0.66886366079586 0.277092927031565 no 2439 0.251791226436098 3572 17015612 SGTC_383 2324-0395 7.37 µM -0.669834864491064 0.276804663042104 no 2440 0.251481532826536 3630 3146421 SGTC_597 k018-0003 82.8 µM -0.671630779386578 0.276272002920139 no 2441 0.250909389233975 3698 6786234 SGTC_188 3229-0966 278.469 µM -0.67327487629103 0.275784812686265 no 2442 0.250386216585993 3715 5722370 SGTC_730 1436-0052 41.2 µM -0.673584831129122 0.275693012035008 no 2443 0.250287649816247 3652 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_179 1273-0063 6.77 µM -0.674141501939163 0.275528178182097 no 2444 0.250110678133368 3608 3108139 SGTC_833 3852-0053 558 µM -0.676184076483612 0.274923774096889 no 2445 0.249461890592693 3674 3123681 SGTC_2024 5144227 134 µM -0.67672721900687 0.274763166587136 no 2446 0.249289521666806 3637 3475211 SGTC_3136 9095672 49.47 µM -0.676748229192982 0.274756954794246 no 2447 0.249282855254259 3480 17217380 SGTC_379 3970-0972 5.9 µM -0.678024267866736 0.274379815836556 no 2448 0.2488781531962 3643 2898042 YBL034C STU1 SGTC_1982 st072467 71.9 µM -0.680214398719736 0.273733109092009 no 2449 0.2481843582877 3626 3163533 SGTC_189 3970-0742 2.116 µM -0.680661304818524 0.273601238337353 no 2450 0.248042913120647 3659 2891807 SGTC_739 1486-1183 203 µM -0.681466181491276 0.273363818784637 no 2451 0.247788279277167 3639 4346692 SGTC_832 4083-0019 164 µM -0.682043443217708 0.273193603097426 no 2452 0.247605740539879 3732 1990758 SGTC_3261 9137475 49.47 µM -0.682725497671844 0.272992555148821 no 2453 0.247390157391792 3527 17027690 SGTC_1859 st055998 20 µM -0.684051366239467 0.272601941299053 no 2454 0.246971365298373 3658 676301 SGTC_3040 9091894 49.47 µM -0.684798999958369 0.272381803486341 no 2455 0.24673538325465 3578 25236966 SGTC_1410 3909-8106 77.9 µM -0.686212892603781 0.271965729902396 no 2456 0.246289434456801 3669 1039210 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.686772896740352 0.271801021997328 no 2457 0.246112925895155 3671 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1048 3161-0300 24.5 µM -0.686919530716174 0.271757902348233 no 2458 0.246066719319094 3671 2165101 SGTC_1783 st039459 87.517 µM -0.686922270295548 0.271757096771287 no 2459 0.246065856080624 3705 729761 SGTC_37 0566-0070 1.56 µM -0.689147660402789 0.271103110723597 no 2460 0.245365175017268 3675 1626686 SGTC_1448 4255-0083 152 µM -0.689727673125383 0.270932788640026 no 2461 0.2451827299092 3693 5399660 SGTC_2449 5812982 45.77 µM -0.692386901483323 0.270152584262831 no 2462 0.244347194695184 3632 776185 SGTC_1649 st011737 51.3 µM -0.694273337268158 0.269599795569398 no 2463 0.243755404269173 3660 1761035 SGTC_1820 st053765 18.6 µM -0.696781562640905 0.268865680530717 no 2464 0.242969753111695 3658 3690829 SGTC_208 k072-0098 12.366 µM -0.697134896273031 0.268762346488862 no 2465 0.242859188638195 3666 5948901 SGTC_204 PMA1.184 62.41 µM -0.698365090594816 0.268402726229615 no 2466 0.242474451120772 3702 2252213 YGL008C PMA1 SGTC_948 3448-0295 75.3 µM -0.700522403097957 0.267772668151555 no 2467 0.241800559630196 3693 678569 SGTC_2860 9025725 38.96 µM -0.700794148421905 0.267693355923601 no 2468 0.241715745193344 3667 40546248 SGTC_969 1313-0238 134 µM -0.701341042018849 0.267533774171715 no 2469 0.241545103186241 3701 5212874 SGTC_2634 4'-methoxyflavone 100 µM -0.701510816630057 0.267484244257203 no 2470 0.241492143338324 3672 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1991 st073000 8.92 µM -0.701515417414284 0.267482902092307 no 2471 0.241490708247824 3733 4301969 YIL048W NEO1 SGTC_3117 9124945 49.47 µM -0.701803118696668 0.267398979112847 no 2472 0.24140097679711 3603 17592065 SGTC_2514 salinomycin 42.74 µM -0.703753601108684 0.266830370375384 no 2473 0.240793116739702 3741 23682228 A polyether potassium ionophore. SGTC_2121 5257820 149.641 µM -0.704331927375135 0.266661892992855 no 2474 0.240613043881448 3744 791256 SGTC_1201 1889-3372 45.9 µM -0.705911650503981 0.266201964004142 no 2475 0.240121540941254 3607 5392199 SGTC_396 dithiazanine 1.25 µM -0.706951754801498 0.265899361915899 no 2476 0.239798229897975 3677 10578 An antihelmenthic. SGTC_787 4152-0075 138 µM -0.70958278385533 0.265134684034886 no 2477 0.238981449404831 3719 9566539 SGTC_3141 9094609 49.47 µM -0.709718465114188 0.265095280165775 no 2478 0.238939369600768 3648 25236309 YDL196W YDL196W SGTC_1981 st071826 47 µM -0.711995399432365 0.264434468459967 no 2479 0.238233812439239 3668 11838600 SGTC_1218 1348-1416 30.7 µM -0.712073756569802 0.264411742588325 no 2480 0.238209552123748 3677 6787668 SGTC_2368 9071271 200 µM -0.713913595855889 0.263878421007282 no 2481 0.23764030485408 3701 27209959 SGTC_2331 7980721 200 µM -0.714437298795314 0.263726713467922 no 2482 0.237478407455824 3680 2981221 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.716620205207311 0.263094843341479 no 2483 0.236804236881327 3715 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_160 3453-0671 289.699 µM -0.716976862105827 0.262991678021607 no 2484 0.236694186789061 3713 5322268 SGTC_2130 NSC 7 2.4545 µM -0.719894061703506 0.262148636072685 no 2485 0.235795112261126 3732 21448 SGTC_503 tyrphostin 8 294 µM -0.720702781237991 0.261915169500392 no 2486 0.235546200435221 3671 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1322 1348-1070 12 µM -0.720932808164318 0.261848783267827 no 2487 0.235475428063669 3676 6758089 SGTC_1383 3049-0032 20.7 µM -0.723201995261736 0.26119435412339 no 2488 0.234777896589263 3746 712864 SGTC_938 3126-1755 342 µM -0.723658405341012 0.261062827944372 no 2489 0.234637737582971 3703 1777771 SGTC_282 k297-0036 65.7 µM -0.72503299162237 0.260666911716014 no 2490 0.234215895445402 3722 5061378 SGTC_3149 9097855 49.47 µM -0.726127532333263 0.260351876967889 no 2491 0.233880296041953 3718 25236625 YMR079W SEC14 SGTC_359 0081-0058 15.9 µM -0.72645361356821 0.260258060998143 no 2492 0.233780367134889 3766 3494159 SGTC_817 1391-0715 46 µM -0.726633350768298 0.260206356731945 no 2493 0.233725296064775 3702 1353946 SGTC_2798 7813637 45.45 µM -0.726754441052181 0.26017152616945 no 2494 0.233688198331409 3704 956368 SGTC_1238 0333-0287 48.8 µM -0.726957034200652 0.260113257393903 no 2495 0.233626138334603 3729 7226 SGTC_2639 lactacystin 53 µM -0.728170467214955 0.259764397045856 no 2496 0.233254620914068 3740 3870 A proteasome inhibitor. SGTC_1397 3532-0190 20.1 µM -0.729512257831834 0.259378915362779 no 2497 0.232844186211607 3643 5322280 SGTC_3299 9121982 43.1275 µM -0.729810200192681 0.259293359914242 no 2498 0.232753104342888 3776 17594604 YPL160W CDC60 SGTC_2056 5235370 200 µM -0.730151345812678 0.259195416372457 no 2499 0.232648839427438 3713 5511916 SGTC_1510 1123-0200 71.5 µM -0.730427508250551 0.259116143631648 no 2500 0.232564454451352 3761 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2313 7726885 200 µM -0.730722805890847 0.259031391979364 no 2501 0.232474241298708 3719 726423 SGTC_1701 st028638 40.4 µM -0.730932870453014 0.258971111302661 no 2502 0.232410078619317 3698 3490878 SGTC_3352 9151559 45.5865 µM -0.731159350664336 0.258906128077857 no 2503 0.232340912936138 3718 17159339 SGTC_1556 plumbagin 1.48 µM -0.73157027267925 0.25878824511244 no 2504 0.232215449085871 3646 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1734 st037168 69.4 µM -0.731953256201669 0.258678401995873 no 2505 0.232098549445761 3773 708907 SGTC_1436 4092-1007 8.32 µM -0.731959314375674 0.25867666465105 no 2506 0.232096700547549 3712 2881121 SGTC_1285 0929-0069 65.5 µM -0.732406190198514 0.258548527612204 no 2507 0.231960340823125 3746 1206237 SGTC_3270 9137563 49.47 µM -0.734115358890122 0.258058744557284 no 2508 0.231439216772296 3721 17015724 SGTC_1122 capsaicin 818.572 nM -0.734445681811576 0.257964142025147 no 2509 0.231338576927652 3811 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1202 1988-0068 29.6 µM -0.734647037345697 0.257906483817424 no 2510 0.231277241693453 3696 2850480 SGTC_2606 farnesol 9.78 µM -0.735050049959118 0.257791101142052 no 2511 0.231154506623092 3752 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2526 patulin 37.61 µM -0.737448210844285 0.257105061161248 no 2512 0.230424913224466 3781 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_245 methotrexate 289.6 µM -0.740277331672767 0.25629695921621 no 2513 0.229565866341493 3725 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_923 1900-2434 73.3 µM -0.740747513438517 0.256162786263009 no 2514 0.229423272332527 3722 5910570 SGTC_1421 4029-0249 71.4 µM -0.742290794075485 0.255722647063992 no 2515 0.228955584145071 3815 2894095 SGTC_1928 4'-methoxychalcone 40.3 µM -0.74232668498743 0.255712415779306 no 2516 0.228944713843451 3767 641818 SGTC_2339 9000433 200 µM -0.742498071961527 0.255663562098897 no 2517 0.228892809763308 3765 2988954 SGTC_1872 amphotericin b 148 nM -0.742738123144502 0.255595143951563 no 2518 0.228820122017693 3764 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1905 st060207 84.5 µM -0.742787313801087 0.255581125065592 no 2519 0.228805228635929 3674 1948547 SGTC_3157 9099274 49.47 µM -0.744332094247925 0.255141081237213 no 2520 0.228337794721493 3703 17217662 SGTC_3249 9135183 49.47 µM -0.744361545107127 0.255132695760628 no 2521 0.228328888425359 3759 4902779 SGTC_977 1348-1378 135 µM -0.744510041686712 0.255090416860832 no 2522 0.228283984237283 3737 X977 SGTC_163 TUB2.036 7.546 µM -0.746925051045176 0.254403347177151 no 2523 0.227554401724199 3796 15992207 YJR013W GPI14 SGTC_1516 st013856 110 µM -0.747815100241716 0.254150373166324 no 2524 0.227285846337273 3774 5281404 A mutagen and neurotoxin. SGTC_2608 thymoquinone 42.66 µM -0.7479225227449 0.254119849957068 no 2525 0.22725344572649 3706 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_182 3448-4371 550.524 µM -0.748674083473646 0.253906354033562 no 2526 0.227026833954632 3735 3491403 SGTC_3144 9087057 49.47 µM -0.749458839346238 0.25368352886883 no 2527 0.226790349174128 3655 17249618 SGTC_2799 7812892 81.82 µM -0.750442785546697 0.253404290371028 no 2528 0.226494035216514 3742 20205235 SGTC_2793 7325131 81.82 µM -0.751309794680292 0.253158371921309 no 2529 0.226233117951955 3763 4176441 SGTC_519 k048-0011 62.8 µM -0.756177675541137 0.251779980442648 no 2530 0.224771337862852 3832 6836379 SGTC_2320 7373003 200 µM -0.759124181429396 0.250947575674711 no 2531 0.223889137542628 3813 5415828 SGTC_959 1222-0044 107 µM -0.759854747030489 0.250741412268378 no 2532 0.223670706938159 3721 6083612 SGTC_1297 1068-0111 14.1 µM -0.760101304986874 0.250671854605198 no 2533 0.223597016338027 3722 767057 SGTC_692 k241-0027 77.8 µM -0.760835939901843 0.250464663784463 no 2534 0.223377532443596 3794 3600480 SGTC_710 3448-4187 58 µM -0.761334145843281 0.25032420524551 no 2535 0.223228755260718 3779 3946412 SGTC_2369 9071472 200 µM -0.761398841398014 0.250305968777675 no 2536 0.223209439633065 3851 17296037 SGTC_361 000s-0510 1.45 µM -0.761501232638904 0.25027710803999 no 2537 0.223178871454309 3780 660 SGTC_825 1988-2224 89.6 µM -0.76153562273957 0.250267414992667 no 2538 0.223168605068337 3771 1180859 SGTC_628 1636-0253 16 µM -0.76241169934835 0.250020554909312 no 2539 0.222907162911002 3790 4456143 SGTC_1739 st037196 92.5 µM -0.762494589335955 0.249997204935046 no 2540 0.222882435599883 3778 612214 SGTC_1686 st019653 115.5 µM -0.764555087306363 0.249417138116012 no 2541 0.22226826098951 3754 97252 SGTC_2942 9052777 62.25 µM -0.765157543076566 0.249247671359484 no 2542 0.222088869031532 3858 6469503 SGTC_1120 ficusin 1.78878 µM -0.765193214716886 0.24923763908729 no 2543 0.222078249756269 3891 6199 A DNA cross-linker. SGTC_747 3448-8087 38.7 µM -0.765419805798767 0.249173917752351 no 2544 0.222010801452782 3816 5168703 SGTC_1836 st055642 81 µM -0.767412252177525 0.248613980601976 no 2545 0.221418223083813 3805 8571 SGTC_1165 k072-0275 30.3 µM -0.767416656727549 0.248612743534321 no 2546 0.221416914118357 3778 6153523 YGL055W OLE1 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.768748344522237 0.248238874374438 no 2547 0.221021359646085 3805 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.769151295857915 0.248125805560455 no 2548 0.220901749777596 3815 521171 SGTC_3269 9137823 49.47 µM -0.770832299435186 0.247654409656236 no 2549 0.22040316980844 3723 17682936 SGTC_1006 4099-6547 255 µM -0.771104870629261 0.247578018894301 no 2550 0.220322386931127 3816 3146833 SGTC_3054 9094397 49.47 µM -0.7726256217657 0.247152044540593 no 2551 0.219871988267748 3804 2598354 SGTC_2201 6605497 169.863 µM -0.772827689540939 0.247095473285024 no 2552 0.219812181945054 3766 670741 SGTC_490 phenamil 164 µM -0.773004380654377 0.247046012201946 no 2553 0.219759894046773 3754 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2311 7694451 200 µM -0.773830258731795 0.246814894689652 no 2554 0.219515588071487 3753 2163142 SGTC_2839 9003951 25.97 µM -0.775381800898023 0.246381017175669 no 2555 0.219057042886148 3804 2990634 SGTC_1851 st056236 18.9 µM -0.775691059563144 0.246294584120281 no 2556 0.218965709982002 3768 5393171 SGTC_417 st075190 100 µM -0.775987295264723 0.246211806028843 no 2557 0.218878243673169 3790 222757 SGTC_2142 5622915 118.518 µM -0.777092101755771 0.245903218022368 no 2558 0.218552216747408 3811 5322196 SGTC_863 0466-0191 129 µM -0.778386176897087 0.24554202873149 no 2559 0.218170692694418 3824 765160 YPR165W RHO1 SGTC_3118 9124250 49.47 µM -0.779992821341989 0.245093995091977 no 2560 0.217697550306808 3766 1504786 SGTC_87 0100-0052 35.5 µM -0.781457380759825 0.244685967110803 no 2561 0.217266766942926 3871 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_226 1,3-diallylurea 8.28947 mM -0.781757550205361 0.244602384736459 no 2562 0.217178536374484 3758 74537 YKL182W FAS1 SGTC_317 4495-0002 170 µM -0.782685938861609 0.244343971675423 no 2563 0.216905780686208 3832 15991618 SGTC_2580 diallyl disulphide 81.36 µM -0.785761587315615 0.24348893007974 no 2564 0.21600358729738 3832 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1596 piperlongumine 63 µM -0.787683216615468 0.242955531578559 no 2565 0.215441012533883 3815 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_576 1073-0113 22.7 µM -0.788111721871651 0.242836674985087 no 2566 0.215315679651425 3959 5439563 SGTC_2616 abietic acid 100 µM -0.788179009040124 0.242818014073756 no 2567 0.215296002769013 3810 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1792 st045773 43.6 µM -0.790749853021158 0.242105617363104 no 2568 0.214544989109237 3729 2919270 SGTC_3289 9119912 71.43 µM -0.791328445947867 0.241945442069569 no 2569 0.214376176519826 3819 17014829 SGTC_1855 st056195 39.6 µM -0.792376140338872 0.241655548995278 no 2570 0.214070693671714 3749 4028379 SGTC_2751 anetholtrithion 17.25 µM -0.792967591218997 0.241491980082945 no 2571 0.213898352554044 3824 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1101 ebselen 5.29 µM -0.794380291328604 0.241101533747057 no 2572 0.213487037121055 3834 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_906 1165-0455 526 µM -0.79439436791075 0.241097644946377 no 2573 0.213482940967287 3803 3252859 SGTC_3105 9121040 49.47 µM -0.795372116767474 0.240827615228688 no 2574 0.213198537294502 3648 41448907 SGTC_2591 skatole 100 µM -0.796432685563099 0.240534898863522 no 2575 0.212890293263917 3870 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_145 3737-0113 38.366 µM -0.796810113763097 0.240430775659232 no 2576 0.212780660201945 3820 6849351 SGTC_2060 5238662 140 µM -0.798336348183915 0.240009975392622 no 2577 0.212337665097098 3816 790130 SGTC_1433 4060-0023 7.6 µM -0.799243359456782 0.239760092386358 no 2578 0.212074657289642 3829 3840627 SGTC_153 4077-0274 519.67 µM -0.800227701202604 0.239489065415254 no 2579 0.211789441476606 3858 3121976 SGTC_2695 st077686 51.995 µM -0.800328170781256 0.239461411705135 no 2580 0.211760342760274 3894 2876092 SGTC_2188 6126565 140.678 µM -0.802682022601204 0.238814025903638 no 2581 0.211079273154617 3779 874518 SGTC_2737 bleomycin 30.5 nM -0.802688119971795 0.238812350172528 no 2582 0.21107751059438 3856 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2843 9000894 45.46 µM -0.803428393473895 0.238608949729601 no 2583 0.210863584651849 3759 2242070 SGTC_2185 6113692 200 µM -0.804110469314456 0.238421623860279 no 2584 0.210666589392281 3819 874150 SGTC_1158 4092-0494 91.8 µM -0.805423649022618 0.238061197978707 no 2585 0.210287624652825 3949 1148199 SGTC_3155 9099265 49.47 µM -0.805573695165731 0.238020034124444 no 2586 0.21024434899601 3852 25236499 SGTC_1832 st054113 55 µM -0.805876841895287 0.23793688036132 no 2587 0.210156932692391 3799 1251267 SGTC_1619 st003326 88.7 µM -0.806585979831426 0.237742424608165 no 2588 0.209952526945588 3786 2849032 SGTC_808 0711-0032 135 µM -0.80710387535213 0.237600465356449 no 2589 0.209803319794117 3786 4252555 SGTC_3185 9108267 49.47 µM -0.808458584051333 0.237229349076431 no 2590 0.209413319337179 3811 4910486 SGTC_1980 st071811 45.7 µM -0.810313336227093 0.23672176495663 no 2591 0.208880056212713 3968 4974850 SGTC_774 k060-0086 136 µM -0.810687758935216 0.236619370400297 no 2592 0.208772502401604 3833 5911235 SGTC_2444 5485484 36.41 µM -0.810737794926457 0.236605688746293 no 2593 0.20875813191683 3927 6790631 SGTC_746 1095-0025 46.6 µM -0.811553563447373 0.236382689463167 no 2594 0.208523923019616 3867 6749286 SGTC_3166 9102297 49.47 µM -0.815357376397269 0.235344404552996 no 2595 0.207433887444317 3872 25237072 SGTC_2344 7990960 76.95 µM -0.816306701083213 0.235085670947045 no 2596 0.207162371362336 3835 140813 SGTC_571 k831-0106 44.2 µM -0.816531526476161 0.23502441895125 no 2597 0.207098099916782 3770 4783639 SGTC_183 3914-0051 30.55 µM -0.817196639280471 0.23484326557944 no 2598 0.20690803139416 3883 1596232 SGTC_237 nikkomycin 200 µM -0.817429327937172 0.234779907588212 no 2599 0.206841560608874 3858 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2347 9049783 174.81 µM -0.818194009643756 0.234571761612089 no 2600 0.206623207575226 3886 6467988 YPL169C MEX67 SGTC_2213 7173844 200 µM -0.819567760407544 0.234198083865473 no 2601 0.206231279417979 3832 892728 SGTC_684 1140-0066 328 µM -0.819826845356871 0.234127646409228 no 2602 0.206157412458571 3903 6813534 SGTC_1404 3909-7820 48.3 µM -0.820505472732928 0.233943203521171 no 2603 0.20596400534001 3818 23741373 SGTC_745 0469-0705 296 µM -0.821655516101366 0.233630819228431 no 2604 0.205636491670877 3933 3486736 SGTC_1283 0922-0125 16.4 µM -0.825122818463199 0.232690403125589 no 2605 0.204650933059727 3879 3360884 SGTC_1789 tunicamycin 25 nM -0.826461529036964 0.232327876260737 no 2606 0.204271166306403 3801 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1893 st059353 36.1 µM -0.826981933264358 0.232187034085656 no 2607 0.204123650855407 3904 3112488 SGTC_958 1222-0007 33 µM -0.827589552602755 0.232022648163723 no 2608 0.203951493449414 3952 7312461 SGTC_1679 SEC14.276 6.7 µM -0.8278804606804 0.231943968555505 no 2609 0.203869100804024 3895 1005053 YMR079W SEC14 SGTC_2963 9082507 9 µM -0.828464590768727 0.231786028385931 no 2610 0.203703720067774 3915 16459611 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.828521498417326 0.231770644599719 no 2611 0.203687612473446 3909 4174840 SGTC_1211 1056-0033 32.3 µM -0.829217539875483 0.231582530461387 no 2612 0.203490660808019 3861 6741922 SGTC_1785 bathophenanthroline 24 µM -0.830528816013176 0.231228372544586 no 2613 0.203119931268899 3818 72812 An iron chelator. SGTC_1661 st013063 9.66 µM -0.830827335619067 0.231147788689225 no 2614 0.203035588924505 3908 721395 SGTC_1141 3253-0389 52.6 µM -0.831455526573466 0.230978262920968 no 2615 0.202858171087749 3822 5402031 SGTC_326 k292-0812 17.5 µM -0.832832926108283 0.230606796204902 no 2616 0.202469481114799 3833 3579357 SGTC_3322 9139058 2.11 µM -0.833564579360118 0.230409614685775 no 2617 0.202263196244045 3989 4908926 YPR165W RHO1 SGTC_532 1548-0774 215 µM -0.834092377587419 0.230267430908491 no 2618 0.202114465056981 4020 5932993 SGTC_335 4077-0256 27.6 µM -0.838114442933273 0.229185538314018 no 2619 0.200983216041257 3875 3121989 SGTC_2127 5253358 187.912 µM -0.841854972794218 0.22818193925337 no 2620 0.199934568355389 3817 20612 SGTC_2199 6590217 200 µM -0.842115953318345 0.22811200947019 no 2621 0.199861526145602 3805 703109 SGTC_1919 st067113 52.3 µM -0.843397821682476 0.227768707608073 no 2622 0.199502994899773 3952 1268243 SGTC_615 k087-0205 167 µM -0.844385594038098 0.227504367160662 no 2623 0.199226984896251 3883 9642773 SGTC_2278 7948257 134.34 µM -0.84477540004223 0.227400097679773 no 2624 0.199118125996379 3902 1247028 SGTC_611 3453-1652 23.7 µM -0.845743099238062 0.227141363550908 no 2625 0.198848037100993 3870 1560575 SGTC_1059 3448-6867 171 µM -0.846420584278504 0.226960322900558 no 2626 0.19865907968228 3834 3934407 SGTC_2088 5278280 127.392 µM -0.847022805159632 0.226799463024447 no 2627 0.198491205138277 3959 791502 SGTC_1606 st000094 49.2 µM -0.849312605028753 0.226188419689211 no 2628 0.19785368435556 3885 1242210 SGTC_205 1486-1330 71.903 µM -0.851790719147364 0.225528173242236 no 2629 0.197165129186077 3895 4118834 SGTC_1092 toremifene 6.32 µM -0.853751107445364 0.225006638690645 no 2630 0.196621454996259 3902 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3126 9127922 49.47 µM -0.855407809474782 0.224566429103608 no 2631 0.196162710874142 3937 45595682 SGTC_2848 9016370 25.97 µM -0.855510395704214 0.224539186539269 no 2632 0.196134325896861 3871 7894410 SGTC_260 nsc-65238 3.989 µM -0.855599471542159 0.224515533284588 no 2633 0.196109681182175 3881 3246252 SGTC_791 1348-1292 225 µM -0.85613982870935 0.224372076803957 no 2634 0.195960220199073 3886 5437054 SGTC_973 1325-0077 65.9 µM -0.856446238972715 0.224290752734277 no 2635 0.19587549885892 3916 2835149 SGTC_411 enrofloxacin 100 µM -0.856461528042097 0.224286695314639 no 2636 0.195871272068272 4014 71188 A bacterial gyrase inhibitor. SGTC_1008 4106-0037 6 µM -0.856514901935906 0.224272531255 no 2637 0.195856516844384 3862 2905394 SGTC_2696 st077691 74.316 µM -0.856697976696098 0.224223951777494 no 2638 0.19580591091426 3943 757133 SGTC_945 3381-0768 11.3 µM -0.857085888935886 0.224121037760287 no 2639 0.195698709579381 3972 1126236 YIL048W NEO1 SGTC_213 1246-0773 967 nM -0.858831331174218 0.223658299965664 no 2640 0.19521678955332 3902 6251622 SGTC_2541 muurolladie-3-one 83.07 µM -0.859693674363082 0.223429883034057 no 2641 0.194978961307551 3950 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2855 9016525 58.44 µM -0.860062253614168 0.223332294490325 no 2642 0.194877363479105 3874 43811474 SGTC_766 1391-0721 126 µM -0.861457352790291 0.22296313452204 no 2643 0.194493099980287 3979 1020919 YIL115C NUP159 SGTC_2931 9014674 55.67 µM -0.861866739851548 0.222854871795229 no 2644 0.194380426757839 3922 2996810 SGTC_1459 k035-0031 35.7 µM -0.863040981866142 0.222544508793382 no 2645 0.194057467478384 3754 3877128 YMR208W ERG12 SGTC_2413 inermin 26.06 µM -0.863593026483812 0.222398683515714 no 2646 0.19390574816203 4038 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_725 1497-0963 19 µM -0.865875865790117 0.221796239400497 no 2647 0.193279119676576 3994 3549977 SGTC_1349 flufenamic acid 69 µM -0.866138821488552 0.22172690499101 no 2648 0.193207019054124 3860 3371 A non-steroidal anti-inflammatory. SGTC_2902 5787006 60.46 µM -0.867467152356201 0.221376848873884 no 2649 0.192843050968922 3890 591003 SGTC_2057 5236571 38.335 µM -0.869010464087828 0.220970535834478 no 2650 0.192420703656888 3920 54684039 YBR257W POP4 SGTC_1334 1486-0610 236 µM -0.869305418914494 0.220892930667048 no 2651 0.192340049857187 4010 3742339 SGTC_3086 9117350 49.47 µM -0.869805739654494 0.220761327638768 no 2652 0.192203287146643 3859 2679265 SGTC_2289 7946404 165.07 µM -0.870674428904073 0.220532936638329 no 2653 0.191965972229622 3962 1246120 YPR165W RHO1 SGTC_1387 3342-1166 1.8 µM -0.872038759571972 0.220174507766137 no 2654 0.191593616550133 3927 3418228 SGTC_2532 xanthone 78.9 µM -0.872515622407998 0.220049308023755 no 2655 0.191463574662697 3930 7020 An insecticide. SGTC_2954 9074818 52.69 µM -0.873251001411223 0.21985631526241 no 2656 0.191263140697816 3946 16648742 SGTC_2006 4011487 200 µM -0.873316607876634 0.21983910223232 no 2657 0.191245265334492 3988 45595294 SGTC_1631 benzylvanillin 81.9 µM -0.873580524384383 0.219769866829164 no 2658 0.191173368081225 4015 75506 SGTC_1188 1403-0014 4.57 µM -0.875480701151239 0.219271747369579 no 2659 0.190656203206087 3942 9614867 SGTC_269 exalamide 29 µM -0.87586899756809 0.21917003780091 no 2660 0.190550627609321 3859 3316 A derivative of salicylamide. SGTC_1043 0916-0009 19.3 µM -0.875874095611045 0.219168702610388 no 2661 0.190549241719067 3950 3101130 SGTC_2416 tofa 880 nM -0.876768127469517 0.218934625701354 no 2662 0.190306297097104 3977 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1521 st012942 49.4 µM -0.877486698824965 0.218746592440164 no 2663 0.190111170175927 3964 24207259 SGTC_2019 4016004 108 µM -0.878564363808458 0.218464767086903 no 2664 0.189818762503777 3971 45595336 SGTC_1405 3909-7894 12 µM -0.879565153644608 0.218203233082765 no 2665 0.189547461522753 3953 7104060 SGTC_196 k015-0023 18.111 µM -0.880746799536198 0.217894668798727 no 2666 0.189227440160342 3885 5211998 SGTC_617 3770-0098 35 µM -0.882828239505455 0.217351752909196 no 2667 0.188664540134751 3880 5962639 SGTC_2497 7-hydroxyflavone 100 µM -0.882892419197534 0.217335024914991 no 2668 0.188647199941362 3979 5281894 SGTC_1807 st050092 58.9 µM -0.884881437854856 0.216816969579981 no 2669 0.188110290179808 3983 5008496 SGTC_809 3998-0021 90 µM -0.885276616331703 0.216714127365595 no 2670 0.188003729293282 3910 715485 SGTC_2586 curcumin 80 µM -0.887312379304911 0.216184782620791 no 2671 0.187455371262561 3938 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_845 0330-0138 4.51 µM -0.887648022170262 0.216097579784111 no 2672 0.187365056709907 3904 9039800 SGTC_3216 9129716 49.47 µM -0.88770662767157 0.216082355671881 no 2673 0.187349289940528 3926 8056934 SGTC_2216 7189485 200 µM -0.888466447882664 0.215885031331418 no 2674 0.187144948064637 3956 731273 SGTC_9 0092-0002 10.449 µM -0.891393557319225 0.215125841375588 no 2675 0.18635903642967 3925 759368 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.892608612989918 0.21481115415138 no 2676 0.186033402556924 4024 1273210 SGTC_419 nsc-638432 893 µM -0.893113971404876 0.214680350179882 no 2677 0.18589807086649 3936 368090 SGTC_358 0075-0058 9.45 µM -0.893149417753703 0.214671177194965 no 2678 0.185888580857049 3832 1069125 SGTC_306 1672-3436 11.6 µM -0.894098047830996 0.214425770552574 no 2679 0.185634716856855 3994 6797378 SGTC_2650 prasterone 100 µM -0.894947440977561 0.21420617458397 no 2680 0.18540759239895 3928 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2371 9071574 200 µM -0.897009224932378 0.213673680446122 no 2681 0.184856997278841 3965 45596039 SGTC_663 1486-0733 13.9 µM -0.897569609215384 0.213529084147074 no 2682 0.184707523634794 3964 722445 YPR165W RHO1 SGTC_2435 5706476 10.6 µM -0.898356960369036 0.213326019818574 no 2683 0.184497637163221 3968 5725375 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.899456787821827 0.213042553849165 no 2684 0.184204701425917 3991 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2194 5927483 104.545 µM -0.90134441402065 0.212556555756582 no 2685 0.183702613047501 3973 760979 SGTC_2827 7993847 71.43 µM -0.902156932439546 0.212347560043601 no 2686 0.183486754589323 4054 2985692 SGTC_1039 k821-0043 94 µM -0.902689653370518 0.21221059894681 no 2687 0.183345314635814 3986 15992768 SGTC_1756 st041558 35.5 µM -0.904264910797355 0.21180590679673 no 2688 0.182927474114531 4068 3955792 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.905390381590152 0.211517044039789 no 2689 0.182629304759023 3953 688667 SGTC_2506 ethyl hematommate 54.16 µM -0.906404061135715 0.211257071112727 no 2690 0.182361012025016 4055 3940691 An allergen. SGTC_2034 5197015 53.07 µM -0.906999021775134 0.211104571988325 no 2691 0.182203657265241 3972 780676 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.907118617704991 0.211073925188058 no 2692 0.182172036867038 3974 2724 A muscle relaxant with antifungal properties. SGTC_913 3487-1245 167 µM -0.909241395989337 0.210530391224953 no 2693 0.181611358739782 3926 4016153 SGTC_675 1309-0189 238 µM -0.910661713462348 0.210167180332034 no 2694 0.181236821500813 4005 4246530 SGTC_2648 atorvastatin 78.68 µM -0.9112517639537 0.210016397863343 no 2695 0.181081367715602 3995 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1261 0712-0010 12.7 µM -0.911667063693819 0.20991030961145 no 2696 0.180972003596315 3996 2840123 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.913589004941967 0.209419760347777 no 2697 0.18046642298332 4001 1377 SGTC_3125 9127534 49.47 µM -0.915313389937834 0.208980209255608 no 2698 0.180013565852147 3872 1639235 SGTC_1656 st012921 11 µM -0.91554757445745 0.208920556832548 no 2699 0.179952119508527 3919 6732821 SGTC_2818 7996756 12.99 µM -0.915685519836669 0.208885423525496 no 2700 0.179915930970485 3995 2241621 SGTC_321 4534-3890 65.3 µM -0.917275888142608 0.208480624092838 no 2701 0.179499044506178 4008 699746 SGTC_1988 st071872 53.4 µM -0.91730629868424 0.208472888150577 no 2702 0.179491078850146 4016 16414116 SGTC_890 0929-0006 47.2 µM -0.918553173585391 0.208155849436958 no 2703 0.179164667114527 3965 1378169 SGTC_2468 5987765 72.9 µM -0.918588483246481 0.208146875512225 no 2704 0.179155429054635 4034 26772094 SGTC_1180 1193-0155 285 µM -0.918996164981205 0.208043280032594 no 2705 0.17904878906205 4068 2921347 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.919484635166762 0.2079191955922 no 2706 0.17892106930755 3818 6708630 An antioxidant. SGTC_3226 9131256 49.47 µM -0.920301704536462 0.207711735914582 no 2707 0.178707559292678 3910 17178073 SGTC_884 0851-0618 334 µM -0.921480467033413 0.207412655361526 no 2708 0.178399817314768 4019 9642473 SGTC_186 3455-3465 67.277 µM -0.923239070859898 0.206966928567647 no 2709 0.177941315995665 3946 755278 SGTC_2008 4012253 172 µM -0.923585278046547 0.206879247477798 no 2710 0.177851140849718 3997 603940 SGTC_3351 9150312 21.596 µM -0.924432709490502 0.206664718175001 no 2711 0.177630535557634 3917 4904905 SGTC_230 MPP+ 141.667 µM -0.924850626707258 0.206558969950156 no 2712 0.177521805994683 3989 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_327 1273-0057 3.96 µM -0.924927970871675 0.206539402584514 no 2713 0.177501687963442 3889 3108138 SGTC_1007 4101-0031 70 µM -0.925538945584004 0.20638487017316 no 2714 0.177342817597775 3958 1146276 SGTC_831 k061-1017 217 µM -0.929468101830647 0.2053927160126 no 2715 0.176323274390499 4044 1240153 SGTC_2274 7947094 46.08 µM -0.929790015566592 0.205311555078028 no 2716 0.176239908438077 3958 2971028 SGTC_2649 anisomycin 9.56 µM -0.931771073754825 0.204812509930842 no 2717 0.175727423329984 3993 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1080 nisoldipine 24.4 µM -0.931992358800459 0.204756811199829 no 2718 0.175670237200945 3999 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_979 1426-2828 121 µM -0.933673601438649 0.204333926997315 no 2719 0.175236143144008 4120 747872 SGTC_661 1304-0007 33.6 µM -0.933819749998865 0.204297190723309 no 2720 0.175198439992717 4015 3117130 SGTC_1200 1643-0193 18.4 µM -0.934378514789674 0.20415677444636 no 2721 0.175054338265757 4009 5403974 SGTC_3039 9090270 49.47 µM -0.935046271297862 0.203989044222198 no 2722 0.174882226953121 4015 17173750 SGTC_374 0880-0231 82.3 µM -0.937948457947641 0.203261013760645 no 2723 0.174135449279112 3933 6833587 SGTC_1952 st077036 64.1 µM -0.938245823925239 0.203186505456062 no 2724 0.174059047042448 4028 2937007 SGTC_3052 9092717 49.47 µM -0.938413211964881 0.203144571720664 no 2725 0.174016049410971 4043 25237534 SGTC_1835 st008666 49.2 µM -0.938745859594721 0.203061252801954 no 2726 0.173930620937791 3970 690455 SGTC_2400 5203494 178.7 µM -0.941143188935914 0.202461392556916 no 2727 0.173315742733255 3938 6777674 SGTC_1314 1222-0010 41.1 µM -0.941538781316246 0.202362509290075 no 2728 0.173214412544581 4026 3526027 SGTC_2933 9026794 32.47 µM -0.941954009086416 0.202258748986215 no 2729 0.173108093381465 3990 17586027 SGTC_46 0329-0187a 2.197 µM -0.942278304448735 0.202177733708715 no 2730 0.173025086397161 4085 46494817 SGTC_1733 st037357 54.9 µM -0.942847092130517 0.202035686400583 no 2731 0.172879560149456 3937 1272339 YGL099W LSG1 SGTC_1058 3448-5425 97.3 µM -0.944028976463088 0.201740717263163 no 2732 0.172577420558011 3896 7279705 SGTC_1932 st074806 40.9 µM -0.944892857844933 0.201525277051178 no 2733 0.172356789095019 4129 17251235 SGTC_3033 9090887 49.47 µM -0.945694053097385 0.20132559316556 no 2734 0.172152328292232 4051 19325384 SGTC_1719 st032227 49.2 µM -0.945932823249722 0.20126610683456 no 2735 0.172091425360106 4035 3125804 SGTC_1965 Pectolinarigenin 58.4 µM -0.946247129102784 0.201187817880021 no 2736 0.172011276559786 4004 5320438 An anti-inflammatory. SGTC_2259 7964009 200 µM -0.946464003804951 0.201133808237487 no 2737 0.171955986849805 4076 313134 SGTC_2252 omeprazole 400 µM -0.946597357752491 0.20110060260026 no 2738 0.171921995429292 3974 4594 A proton pump inhibitor. SGTC_2063 5246145 200 µM -0.948305343139671 0.200675598573752 no 2739 0.171487015781886 4071 711240 SGTC_3224 9130643 49.47 µM -0.948630685320351 0.200594703712272 no 2740 0.171404239367414 4080 17644395 SGTC_99 0109-0120 622.8 µM -0.949626818790802 0.200347141411979 no 2741 0.171150953180302 4006 759414 SGTC_193 1273-0060 1.558 µM -0.951241117991756 0.199946340542 no 2742 0.17074099493969 3839 2847393 YHR072W ERG7 SGTC_381 3461-2219 42.7 µM -0.951852737315407 0.199794612715375 no 2743 0.170585835884024 4040 2883159 SGTC_592 k241-0073 46.5 µM -0.952936094366267 0.19952602831582 no 2744 0.170311225370275 4041 4230158 SGTC_3162 9099653 49.47 µM -0.953385592011834 0.199414653292539 no 2745 0.170197369393787 4017 25237511 SGTC_394 menadione 8.33 µM -0.956114117876377 0.198739391789721 no 2746 0.169507291443542 4022 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1475 4092-1048 11.7 µM -0.956226664011816 0.198711568266767 no 2747 0.169478865740037 4061 2881759 SGTC_2196 6573537 42.6665 µM -0.956332997132318 0.198685282876035 no 2748 0.169452012063988 4065 2903087 SGTC_2102 5377816 72.7585 µM -0.956775868209267 0.198575828351908 no 2749 0.169340197482187 4089 1379702 SGTC_1406 3909-7906 11.9 µM -0.958242902149376 0.198213514295862 no 2750 0.168970144103638 4041 X1406 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.959257785453912 0.197963101772177 no 2751 0.168714448096585 4045 77254 SGTC_1118 chelidonine 707.474 nM -0.960964184696598 0.197542495429086 no 2752 0.16828508813911 4018 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_919 tnp00227 403.569 nM -0.961335150159654 0.197451128566525 no 2753 0.168191839814516 4018 1269246 A methoxyflavone. YNL221C POP1 SGTC_632 0781-2353 4.65 µM -0.962332995044346 0.197205491406209 no 2754 0.167941179947123 4119 6811515 YHR007C ERG11 SGTC_2298 7976326 193.81 µM -0.962564044081271 0.197148640972461 no 2755 0.167883174445635 3926 2235818 SGTC_341 1486-1430 230 µM -0.963881980673503 0.196824547662452 no 2756 0.167552549452911 4027 2054753 YPL210C SRP72 SGTC_283 0987-0079 11.7 µM -0.966429806056629 0.19619892821553 no 2757 0.166914577716278 4061 411556 SGTC_3217 9129673 49.47 µM -0.966509010446468 0.196179498893793 no 2758 0.166894770196888 4100 17248312 SGTC_705 1124-0212 310 µM -0.966713920640672 0.196129238582717 no 2759 0.166843533069676 4005 9554485 SGTC_3170 9103054 49.47 µM -0.967638748788815 0.195902494186474 no 2760 0.166612409068589 4052 16432970 SGTC_918 glabranin 770.725 nM -0.969546986099017 0.195435145767235 no 2761 0.166136174460629 4063 124049 Also referred to as licorice root. SGTC_2643 anethole 100 µM -0.971284974729113 0.195010082937973 no 2762 0.165703194418096 4044 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_773 4358-1457 44.6 µM -0.971577487452497 0.194938597904223 no 2763 0.165630393372862 4020 1186886 SGTC_1811 st050069 61.5 µM -0.973769598310372 0.194403391344387 no 2764 0.165085475677199 3987 3877702 SGTC_1115 galangin 695.678 nM -0.973895096246047 0.194372777965784 no 2765 0.165054314404751 4114 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2108 5365811 200 µM -0.974128271956761 0.194315905968355 no 2766 0.164996426736467 4082 780283 SGTC_180 1486-1293 102.781 µM -0.97626466265938 0.193795308055232 no 2767 0.164466663343174 3941 4140536 SGTC_2267 7931562 200 µM -0.97850144447204 0.193251158796965 no 2768 0.163913188632196 3987 934880 SGTC_2341 7987486 176.74 µM -0.978995149923237 0.193131179196823 no 2769 0.16379118797416 4107 1258686 SGTC_1376 2910-0861 41.3 µM -0.983477836626815 0.192043885141979 no 2770 0.162686159077894 4009 1112859 SGTC_1625 st003711 30.1 µM -0.983598497845201 0.192014670134062 no 2771 0.162656482011442 4163 24207034 YER133W GLC7 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.983966694548555 0.191925537595 no 2772 0.16256594446127 4148 5282309 SGTC_2321 7390090 138.78 µM -0.984538702416224 0.191787116980038 no 2773 0.162425355913277 4101 649046 SGTC_1805 st050013 60.3 µM -0.9857227412151 0.191500784821089 no 2774 0.162134593414141 4004 4037144 SGTC_3246 9135460 32.98 µM -0.988590849584236 0.19080828608919 no 2775 0.161431682490194 4041 41446951 SGTC_2408 sulbentine 18.36 µM -0.989233710224273 0.1906532797977 no 2776 0.161274404373125 4044 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3283 9109332 35.8195 µM -0.992162944871344 0.189947962890181 no 2777 0.160559022615211 3912 17027281 SGTC_2440 5628896 157.78 µM -0.992212882020992 0.189935952676711 no 2778 0.160546844892848 4068 5522048 SGTC_1339 1486-1321 22.7 µM -0.99475092050991 0.189326152655786 no 2779 0.159928710973192 4089 3469382 SGTC_357 1325-0123 420 µM -0.995746454873043 0.189087290735245 no 2780 0.159686676266344 4114 1098503 SGTC_1616 st002734 56.1 µM -0.997032477071341 0.188779005966747 no 2781 0.159374373023337 4031 4026101 SGTC_564 3555-0129 330 µM -0.997446047764561 0.18867993081559 no 2782 0.159274024751233 3916 563260 SGTC_42 0133-0086 60.653 µM -0.997578107999205 0.188648301168727 no 2783 0.159241990539908 3969 162923 Model of phenazepam hydroxylation. SGTC_2275 7947463 200 µM -0.997953230747147 0.188558473634245 no 2784 0.159151019009807 4077 1225414 SGTC_1799 st045822 46.1415 µM -0.999090115505475 0.188286394390674 no 2785 0.158875519504359 4056 3674992 SGTC_934 2950-0684 338 µM -0.999638638801311 0.18815520847103 no 2786 0.158742708561017 4145 1121253 SGTC_185 k048-0037 25.491 µM -1.00262569898994 0.187441807623859 no 2787 0.158020745752334 4142 6827589 SGTC_1897 st060201 15 µM -1.00362922441991 0.18720251089341 no 2788 0.157778681396492 4141 611878 SGTC_2689 tacrolimus 100 µM -1.00707343319415 0.186382656207578 no 2789 0.156949743442162 4127 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_547 1120-0019 610 nM -1.00717145795305 0.186359355130012 no 2790 0.156926193255535 4053 3676939 SGTC_2103 5378138 10 µM -1.00760288753094 0.186256823164019 no 2791 0.156822571085524 4170 244142 SGTC_1035 k081-0041 55.2 µM -1.00962541876542 0.185776622024402 no 2792 0.156337393341126 4133 731709 SGTC_332 4112-0506 40.9 µM -1.01239874874864 0.185119411620377 no 2793 0.155673718193464 4051 2790355 SGTC_798 1287-0182 476 µM -1.01260228191986 0.185071236257767 no 2794 0.155625084731332 4146 1649755 SGTC_2117 5521686 200 µM -1.01517706337284 0.184462469995367 no 2795 0.155010716006318 4052 803312 SGTC_2078 5212016 200 µM -1.01532066188997 0.184428555113031 no 2796 0.154976499174876 3962 1899708 SGTC_2316 5844804 197.44 µM -1.01723745698648 0.183976220848243 no 2797 0.154520240572954 4127 776813 SGTC_236 1509-0011 5.31 µM -1.01825377126193 0.183736666736299 no 2798 0.15427868578627 4165 3107280 SGTC_1055 3448-0672 86 µM -1.02005063347123 0.183313606446133 no 2799 0.153852223868918 4137 748378 SGTC_2825 7998094 58.44 µM -1.02008590034291 0.183305309157822 no 2800 0.153843861549121 4112 2987815 SGTC_3194 9111903 49.47 µM -1.02719197530781 0.1816382321317 no 2801 0.152165038004605 4164 17087251 SGTC_1673 st016611 27.3 µM -1.02985683925193 0.18101551191332 no 2802 0.151538607063758 4144 5226799 SGTC_470 aa-861 153 µM -1.0310855131036 0.180728848906089 no 2803 0.151250360353705 4098 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2115 tiliquinol 12.7705 µM -1.03308340233936 0.180263327625956 no 2804 0.150782434976017 4096 71208 A bioactive hydroxyquinoline. SGTC_2504 purpurogallin 52.29 µM -1.03761269522762 0.179210762508165 no 2805 0.149725202555966 4027 5281571 An antioxidant. SGTC_859 0439-0102 54.6 µM -1.04008020909874 0.178638965427127 no 2806 0.14915131877472 4135 610143 SGTC_2246 7293507 91.5585 µM -1.04124012815928 0.178370574735466 no 2807 0.148882058039941 4180 887656 SGTC_3076 9116187 49.47 µM -1.04379114831215 0.177781195119449 no 2808 0.14829101391243 4121 27241210 SGTC_2447 5741742 33.78 µM -1.04652683193427 0.177150518254981 no 2809 0.147658931695893 4206 1776504 SGTC_998 3996-0085 177 µM -1.04919225430296 0.176537400250177 no 2810 0.147044821431263 4169 715391 SGTC_1432 4049-0298 68.4 µM -1.05128793881422 0.176056280718692 no 2811 0.146563182431587 4167 741646 SGTC_2847 9005661 71.43 µM -1.05135724713008 0.176040383364531 no 2812 0.146547271812292 4144 2991449 SGTC_2151 5563267 85.4165 µM -1.05630769916282 0.174907241953675 no 2813 0.145413829800492 4193 5310824 SGTC_1497 4476-2978 41.3 µM -1.05687654758474 0.174777331653004 no 2814 0.145283966545053 4189 1528379 SGTC_451 chloral hydrate 100 µM -1.05767217257099 0.174595734207403 no 2815 0.145102463054414 4168 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_296 1222-0039 74.9 µM -1.06173215937131 0.173670929030133 no 2816 0.144178647705894 4161 5984176 SGTC_415 dibenzyl ketone 100 µM -1.06267925965739 0.173455642658948 no 2817 0.143963714787232 4137 7593 SGTC_276 colchicine 750 µM -1.06335093540524 0.173303066327574 no 2818 0.143811417168188 4221 2833 A microtubule depolymerizer. SGTC_2967 9089538 49.85 µM -1.06362980540726 0.173239743965546 no 2819 0.143748217356983 4176 728216 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.06453790048518 0.173033647048246 no 2820 0.143542547276728 4146 688662 SGTC_1026 k007-1105 30.6 µM -1.06659520274724 0.172567309608127 no 2821 0.143077333853616 4150 7066794 SGTC_2862 9027634 71.43 µM -1.06859416379777 0.172114965015194 no 2822 0.142626289745228 4111 5012562 SGTC_3010 9080089 71.4286 µM -1.06944776600211 0.171922034292252 no 2823 0.142433976824306 4188 17027233 SGTC_2626 ethyl orsellinate 100 µM -1.07011277674166 0.171771824644433 no 2824 0.142284274361161 4137 75653 A natural product. SGTC_702 1488-0190 94 µM -1.07016388037686 0.171760285053396 no 2825 0.14227277468265 4193 949357 SGTC_339 3091-4833 71.4 µM -1.07104570265617 0.171561240841407 no 2826 0.142074440241985 4030 3240077 SGTC_2654 protoveratrine a 100 µM -1.07173427541272 0.171405919274038 no 2827 0.141919700564946 4157 5702278 A heart drug and vasodilator. SGTC_1367 1812-0510 76.9 µM -1.07222945265627 0.171294277568395 no 2828 0.141808492303108 4208 1142582 YDR527W RBA50 SGTC_954 1189-0853 2.85 µM -1.07255486239028 0.17122093663686 no 2829 0.141735443035954 4109 2828194 SGTC_1361 1608-0041 5.61 µM -1.0734678892081 0.17101526563152 no 2830 0.141530619251959 4126 X1361 SGTC_2279 7948423 32.93 µM -1.07350996048611 0.171005792346711 no 2831 0.141521186031916 4157 1247112 SGTC_2762 leflunomide 42.06 µM -1.07429672453709 0.170828696746013 no 2832 0.141344856308383 4142 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1490 4089-0339 670 nM -1.07436732270381 0.170812811286366 no 2833 0.141329041116409 4136 742542 SGTC_2605 digitonin 300 nM -1.07472695917355 0.170731903312022 no 2834 0.141248495039588 4213 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2288 7946289 167.31 µM -1.07583115005883 0.170483645074115 no 2835 0.141001389120405 4237 1246052 SGTC_1989 st071868 50.2 µM -1.07731992721053 0.170149285417035 no 2836 0.14066868139779 4157 16414057 SGTC_974 1326-0144 138 µM -1.07746196103261 0.170117408471174 no 2837 0.140636967942225 4199 5411856 SGTC_2874 9043904 71.43 µM -1.07822850286909 0.169945437963161 no 2838 0.140465897472245 4118 4463428 SGTC_7 0192-1582 4.227 µM -1.08281676204361 0.168918411981769 no 2839 0.13944488197104 4220 252616 SGTC_1388 3346-4487 254 µM -1.08676466740154 0.168037919584908 no 2840 0.138570413218227 4242 3345614 SGTC_2432 5630864 12.22 µM -1.08724636927445 0.167930689247209 no 2841 0.13846397162952 4220 5714970 SGTC_134 0269-0018 6.916 µM -1.0872513501935 0.167929580688558 no 2842 0.138462871287733 4145 4378915 SGTC_2786 7743617 45.45 µM -1.08746107274263 0.167882908889228 no 2843 0.138416546593839 4133 583674 SGTC_2769 toremifene 3.73 µM -1.08807534822771 0.167746255655962 no 2844 0.138280922759421 4228 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2309 7664088 163.95 µM -1.09102568231368 0.167090915588408 no 2845 0.137630790990084 4203 704922 SGTC_453 enantio-paf c16 10 µM -1.09146906635964 0.166992572217328 no 2846 0.137533268075891 3966 13871343 A lipid and platelet activating factor SGTC_2700 st077718 96.8 µM -1.09389982306726 0.166454089493643 no 2847 0.136999458189883 4181 904970 SGTC_2767 sibutramine 71.45 µM -1.09425171169357 0.166376229004894 no 2848 0.136922298644324 4215 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_737 1950-0117 57.9 µM -1.09492485352809 0.166227352092389 no 2849 0.136774779822472 4177 5393513 SGTC_1204 4049-0315 18.3 µM -1.09545742511095 0.166109625700707 no 2850 0.136658143939614 4238 588402 SGTC_1727 st034309 9.9045 µM -1.09812343889531 0.165521106108388 no 2851 0.136075295857874 4255 870305 SGTC_2742 clothiapine 36.27 µM -1.09850476719998 0.165437038689935 no 2852 0.135992068573631 4193 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2738 aclarubicin 5.55 µM -1.09876035816221 0.165380706718066 no 2853 0.135936303760785 4154 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_80 0159-0065 512.242 µM -1.10185209046727 0.164700275434742 no 2854 0.135262989964157 4092 1548079 SGTC_1004 4084-0029 199 µM -1.10276330228979 0.164500081645101 no 2855 0.135064984281174 4220 716894 YLR208W SEC13 SGTC_474 dl-dihydrosphingosine 5 µM -1.10423387048249 0.164177329721005 no 2856 0.13474585028922 4224 3058739 A sphingolipid protein kinase C inhibitor. SGTC_427 1354-0053 47.3 µM -1.10613082807608 0.163761603282767 no 2857 0.134334948552443 4270 6813657 SGTC_1302 1159-0335 255 µM -1.10834906656693 0.163276334212999 no 2858 0.133855546285852 4216 649284 SGTC_728 3030-5151 22.5 µM -1.10867443375018 0.163205234479376 no 2859 0.133785327445444 4272 3125388 SGTC_2929 9013348 24.6 µM -1.1129823754884 0.162265753481031 no 2860 0.132857999485326 4200 2995952 SGTC_432 NS 1619 61.3 µM -1.1140339581907 0.162036958764875 no 2861 0.132632309366481 4218 4552 A K+/calcium channel activator. SGTC_775 4577-0580 57.3 µM -1.11887835317149 0.160985670116112 no 2862 0.131596019502069 4269 2006902 SGTC_622 1348-1566 26.3 µM -1.1214701365909 0.160425055797017 no 2863 0.131043898148622 4218 7340407 SGTC_2598 perillyl alcohol 100 µM -1.12456009370369 0.159758353270494 no 2864 0.130387746071665 4258 10819 An apoptosis inducer. SGTC_1251 0490-5699 265 µM -1.12653510683269 0.159333166879209 no 2865 0.129969544671593 4263 3883818 SGTC_1848 st056003 16.4 µM -1.12796204546604 0.159026433008705 no 2866 0.129667974290273 4228 146492 SGTC_1227 3909-8010 46.6 µM -1.12848046325625 0.158915090110289 no 2867 0.12955853156753 4199 15982272 SGTC_3304 9125678 46.087 µM -1.12893098466265 0.158818371121157 no 2868 0.129463474373168 4153 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_280 3448-3607 3.04 µM -1.1301108914248 0.158565248868354 no 2869 0.12921475048278 4186 626179 SGTC_872 0588-0139 234 µM -1.13042092661143 0.158498781762009 no 2870 0.129149450174864 4184 2047100 SGTC_478 N-arachidonylglycine 10 µM -1.13059148661523 0.158462223931372 no 2871 0.129113536200106 4196 5283389 SGTC_1018 4259-0013 28.1 µM -1.13107748708022 0.158358084928938 no 2872 0.129011239467624 4274 6801262 SGTC_3262 9137218 49.47 µM -1.13120034640151 0.158331766042747 no 2873 0.128985388092031 4136 17650664 SGTC_1697 st025554 27.742 µM -1.13294183911451 0.15795901267344 no 2874 0.128619339193025 4217 1269519 SGTC_1073 triclabendazole 3.09 µM -1.13309354294917 0.157926568917088 no 2875 0.128587486335795 4265 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1291 0993-0025 5.79 µM -1.13465052049013 0.157593842776886 no 2876 0.128260888239827 4214 4353356 SGTC_3032 9089427 49.47 µM -1.13802846198616 0.156873561349794 no 2877 0.127554298889073 4226 17173707 SGTC_1913 st060213 96.1 µM -1.1384532750079 0.156783131671076 no 2878 0.127465629523811 4261 688959 SGTC_1791 st048313 56.1 µM -1.13860984766667 0.156749810802014 no 2879 0.127432959610094 4237 1204976 SGTC_3160 9100216 49.47 µM -1.14249117703325 0.155925299044846 no 2880 0.126624955686681 4199 17191039 SGTC_2928 9011484 9.79 µM -1.14341280144639 0.155729938923656 no 2881 0.126433619956945 4244 2994751 SGTC_2619 obliquin 87.91 µM -1.14367727295623 0.155673907741638 no 2882 0.126378751020161 4193 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2642 cholecalciferol 100 µM -1.14630880617356 0.155117113041692 no 2883 0.125833700246019 4230 9821465 A vitamin D precursor, similar to steriods. SGTC_2620 irigenin 100 µM -1.14871140087435 0.154609908065644 no 2884 0.12533750158052 4270 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1696 st025591 34.7925 µM -1.14912165629043 0.154523409884479 no 2885 0.125252909825286 4244 2787147 SGTC_2570 licareol 100 µM -1.15153444691594 0.154015344879106 no 2886 0.124756216132131 4226 443158 SGTC_907 3448-6986 75.5 µM -1.15177115812892 0.153965559841301 no 2887 0.124707561341929 4282 590582 SGTC_151 3013-0144 2.285 µM -1.15183340715785 0.153952469411075 no 2888 0.124694768572111 4081 906558 YHR107C CDC12 SGTC_1427 4048-4900 550 nM -1.15297264402328 0.153713027868721 no 2889 0.124460806499636 4239 24132586 SGTC_111 0083-0039 52.457 µM -1.15378910666695 0.153541577827261 no 2890 0.124293320642322 4137 759313 SGTC_1071 trifluoperazine 6.31 µM -1.15379221719006 0.153540924886764 no 2891 0.124292682863715 4318 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2398 5228213 48.84 µM -1.15449375384352 0.153393709913512 no 2892 0.124148898945248 4242 80771 YMR134W ERG29 SGTC_2345 9052315 157.45 µM -1.16031244093718 0.152176283983242 no 2893 0.122960810541698 4279 6469265 SGTC_192 3455-0609 60.9 µM -1.16210877931879 0.151801741252032 no 2894 0.122595640865198 4313 3769639 SGTC_2910 7948405 25.97 µM -1.1633128140597 0.151551039033417 no 2895 0.122351304268406 4160 2971328 SGTC_1023 4482-3888 16 µM -1.16468447374187 0.151265769795405 no 2896 0.122073368008756 4272 3303168 SGTC_935 2996-0153 430 µM -1.16520025289164 0.15115859372375 no 2897 0.121968971651218 4253 23738523 SGTC_270 tamoxifen 5.46 µM -1.16956188034087 0.150254291845377 no 2898 0.121088662625095 4313 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1705 st027868 56.3335 µM -1.17049958052697 0.150060349116018 no 2899 0.120899991429886 4190 292948 SGTC_152 4469-0003 551.229 µM -1.17145715658881 0.149862467813314 no 2900 0.120707534677221 4238 697280 SGTC_920 mycophenolic acid 780.421 nM -1.17220616641363 0.149707807692173 no 2901 0.120557146642081 4242 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2980 9014342 25.29 µM -1.17369367987821 0.149400972665418 no 2902 0.12025887132896 4321 2996599 SGTC_1399 3562-5772 25 µM -1.17383715752723 0.149371399202823 no 2903 0.120230128793277 4235 23847490 SGTC_2349 9023730 187.07 µM -1.17566449511217 0.148995092143262 no 2904 0.119864485926726 4285 4126287 SGTC_1552 6-methylflavone 10.6 µM -1.17732316330803 0.148654068293572 no 2905 0.119533272515861 4210 689013 SGTC_3003 9075612 71.4286 µM -1.17872794460287 0.148365652259249 no 2906 0.119253262239606 4292 6501993 SGTC_1359 1582-0056 520 nM -1.18468368958458 0.147147035972212 no 2907 0.118071266835803 4333 3661189 SGTC_1088 bifonazole 369 nM -1.18511969171175 0.147058089111467 no 2908 0.117985063180307 4240 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_881 0833-0569 170 µM -1.18784579963471 0.146502765446364 no 2909 0.117447083310974 4286 5418700 SGTC_1748 st037455 53.6035 µM -1.19072140081663 0.145918516556812 no 2910 0.116881486822077 4320 580690 SGTC_458 nppb 133 µM -1.19083536424368 0.145895394392245 no 2911 0.116859111414706 4323 4549 A chloride channel blocker. SGTC_194 1486-1323 56.904 µM -1.19144669514715 0.145771402826678 no 2912 0.116739135455059 4363 5178754 SGTC_2718 lomofungin 53.02 µM -1.19194612860471 0.145670159148381 no 2913 0.116641184619655 4252 5351222 A RNA synthesis inhibitor. SGTC_713 1488-1073 324 µM -1.19316304093638 0.145423668236249 no 2914 0.116402763069038 4288 3312542 SGTC_2856 9022925 19.48 µM -1.19507293970695 0.145037375861689 no 2915 0.116029266744452 4320 4944862 SGTC_2669 eugenol 100 µM -1.19623306305673 0.144803069085176 no 2916 0.115802810882606 4285 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2711 st079103 59.1 µM -1.1962354000193 0.144802597352965 no 2917 0.115802355024943 4229 54693780 SGTC_1272 0839-0021 27 µM -1.1995777102947 0.144128987712869 no 2918 0.115151693772069 4298 5027250 SGTC_2113 5491891 107.031 µM -1.20394197865515 0.143252597909383 no 2919 0.11430600255896 4283 789979 SGTC_3348 9149464 3.537 µM -1.20433351051199 0.143174150601569 no 2920 0.114230349755408 4223 1951442 SGTC_1895 st058434 18.3 µM -1.20483981260342 0.143072750965189 no 2921 0.11413257362628 4304 5393175 SGTC_784 4579-0127 173 µM -1.20869454678809 0.142302335236924 no 2922 0.113390108748784 4316 1948547 SGTC_1372 2752-0194 270 µM -1.20945627506396 0.142150427285665 no 2923 0.113243799912871 4226 823334 SGTC_1620 st003704 16.5 µM -1.21028225785465 0.141985829421398 no 2924 0.11308530165565 4282 2834414 SGTC_2518 prenyletin 46.28 µM -1.21819938797833 0.140414688001783 no 2925 0.111574106094726 4300 3873459 A coumarin with calcium channel inhibitory activity. SGTC_69 0096-0274 206.684 µM -1.21963788498238 0.140130492794482 no 2926 0.11130108903371 4414 6741392 SGTC_1009 4106-0057 9.87 µM -1.22204322363194 0.139656158011358 no 2927 0.110845640947702 4302 2928005 SGTC_3029 9088683 49.47 µM -1.22390597116647 0.139289573584579 no 2928 0.110493850404282 4336 25236615 SGTC_1659 st012954 42.1 µM -1.22577884390342 0.138921657177109 no 2929 0.11014095530899 4254 24207262 SGTC_2335 9018011 154.17 µM -1.22777997181387 0.138529277510748 no 2930 0.109764788024847 4300 6458208 SGTC_687 k029-0044 34.9 µM -1.22882774995743 0.138324131450334 no 2931 0.109568197413764 4389 5829338 SGTC_1041 0206-0046 107 µM -1.22901407968345 0.1382876713714 no 2932 0.109533263573835 4304 50494 SGTC_130 0136-0219 337.655 µM -1.22934967833642 0.138222019614384 no 2933 0.109470364377663 4141 234244 SGTC_1817 st052116 64.4 µM -1.23218218587339 0.137668754611936 no 2934 0.108940518110318 4330 4361398 SGTC_1555 citronellol 128 µM -1.23392805385962 0.137328493462208 no 2935 0.10861485736113 4281 8842 A terpine precursor. SGTC_2973 9094665 17.96 µM -1.2366543122595 0.136798308478675 no 2936 0.108107723560763 4318 25237061 YIL048W NEO1 SGTC_3090 9117696 49.47 µM -1.23730128563078 0.136672695009041 no 2937 0.107987625380762 4274 7923821 SGTC_2523 spermine 47.74 µM -1.23775611988661 0.136584433639531 no 2938 0.107903251666897 4343 1103 A DNA binding polyamine. SGTC_1132 3456-3614 2.5 µM -1.24007649454606 0.136134767661285 no 2939 0.107473551052153 4348 3125502 SGTC_1418 3966-3099 2.4 µM -1.24284433819462 0.135599713052353 no 2940 0.106962600158712 4325 740335 SGTC_971 1315-0384 26.7 µM -1.24352752563463 0.135467867405939 no 2941 0.106836752124044 4354 6769120 SGTC_3295 9122362 53.5725 µM -1.24457348213476 0.135266182643387 no 2942 0.106644286469369 4322 4730473 SGTC_2800 7887935 81.82 µM -1.24462335738382 0.135256570678679 no 2943 0.106635115218162 4318 2961002 SGTC_3240 9133527 49.47 µM -1.24545679049786 0.135096020621848 no 2944 0.106481944586174 4271 17617455 SGTC_1813 st051246 8.6015 µM -1.24622689809464 0.134947785613538 no 2945 0.106340553350209 4263 5291959 SGTC_2391 6285546 200 µM -1.24828516960267 0.134552144682011 no 2946 0.105963321647885 4337 846083 SGTC_2515 chrysin 20.77 µM -1.24968311059193 0.134283886945478 no 2947 0.105707664691341 4334 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_161 4065-0411 162.148 µM -1.25115206736244 0.134002397655318 no 2948 0.105439501104767 4313 1906281 YLR208W SEC13 SGTC_2225 6654152 15.4 µM -1.25185819933127 0.133867229297508 no 2949 0.105310769317183 4242 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2167 5876490 200 µM -1.25229382749915 0.133783887751775 no 2950 0.105231408611659 4391 686534 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.25575940961652 0.133122145647594 no 2951 0.104601606116768 4315 688803 SGTC_2396 5342950 42.78 µM -1.25803798730848 0.132688287832545 no 2952 0.104189009198688 4308 1886677 SGTC_1280 0880-0253 10.1 µM -1.260007055136 0.132314148249871 no 2953 0.103833408583869 4308 6836607 SGTC_542 3381-0244 89.3 µM -1.26165808446136 0.132000999643429 no 2954 0.103535922824795 4353 1112843 SGTC_569 4130-2812 160 µM -1.27003900534005 0.130419286029863 no 2955 0.102035368246076 4190 743552 SGTC_3018 9082602 49.47 µM -1.27304096029796 0.129855935138793 no 2956 0.101501753706399 4275 17332089 SGTC_1145 3546-0597 10.2 µM -1.27349482891262 0.12977090839141 no 2957 0.101421253184505 4305 875334 SGTC_749 1000-0129 128 µM -1.27432971388338 0.12961460358151 no 2958 0.10127329507304 4393 708470 SGTC_3133 9127736 49.47 µM -1.2749121985265 0.129505629709407 no 2959 0.101170160465331 4351 27243420 SGTC_899 1083-0020 478 µM -1.27539002342969 0.129416283462442 no 2960 0.10108561405241 4406 767123 SGTC_2519 cryptotanshinone 88.04 µM -1.27776642360979 0.128972565988854 no 2961 0.100665898289652 4327 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3333 9141820 12.094 µM -1.2782961749422 0.128873795685758 no 2962 0.10057250801766 4333 1939433 SGTC_3186 9110464 49.47 µM -1.27958991388514 0.128632803098631 no 2963 0.100344699471548 4342 17018021 SGTC_2493 resveratrol 26.09 µM -1.2801489237663 0.128528769757809 no 2964 0.100246382588763 4272 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1643 st009866 20.2 µM -1.28021989162367 0.128515566614783 no 2965 0.100233906018961 4312 3156273 YOR207C RET1 SGTC_669 0108-0021 26.2 µM -1.2807925791818 0.128409055988027 no 2966 0.10013326562975 4371 17201 SGTC_2914 7968218 45.32 µM -1.28227358665516 0.128133896746222 no 2967 0.0998733451168628 4318 2977111 SGTC_1254 0550-0035 264 µM -1.2825813690812 0.128076764689737 no 2968 0.0998193904346622 4358 15121435 SGTC_2295 7971645 200 µM -1.28550446290675 0.127535047933579 no 2969 0.0993080290983587 4400 2978226 YKL099C UTP11 SGTC_223 busulfan 5 mM -1.28688564492474 0.127279638039662 no 2970 0.0990670747217849 4344 2478 A DNA alkylator. SGTC_496 calpeptin 138 µM -1.28726402183208 0.127209730245545 no 2971 0.0990011395861353 4351 73364 A calpain inhibitor. SGTC_1492 4158-0558 28.5 µM -1.28824900035558 0.127027873834666 no 2972 0.0988296499361492 4367 3967268 SGTC_414 piperonyl butoxide 100 µM -1.28854133373483 0.126973935210157 no 2973 0.0987787950973273 4352 5794 A potent inhibitor of cytochrome P450. SGTC_1674 st016616 23.6 µM -1.28944192679716 0.126807866402052 no 2974 0.098622246688747 4299 625830 SGTC_2938 9059746 27.26 µM -1.29171131284458 0.126390063852012 no 2975 0.0982285691226848 4364 6471769 SGTC_631 k072-0230 41.5 µM -1.29278292696366 0.1261931093958 no 2976 0.0980430734595064 4355 5773147 SGTC_222 nsc-310342 10.666 µM -1.29368609912166 0.126027279489491 no 2977 0.0978869344146903 4386 432556 SGTC_225 nsc-122657 1.016 µM -1.29413057728696 0.125945725417808 no 2978 0.0978101606473799 4364 275685 SGTC_3111 9122088 49.47 µM -1.30006722263253 0.124859980923093 no 2979 0.09678896524107 4250 16876704 SGTC_2946 9065502 71.43 µM -1.30081061393619 0.124724485293275 no 2980 0.0966616439997033 4203 16489101 SGTC_3325 9138760 55.175 µM -1.30082231869723 0.124722352724783 no 2981 0.0966596402998194 4304 43844959 SGTC_2820 7989630 71.43 µM -1.30190562324736 0.124525088556568 no 2982 0.0964743249763329 4391 2984098 SGTC_275 trichlorophene 5.69 µM -1.30321416926912 0.124287100081651 no 2983 0.0962508270205635 4408 62616 SGTC_1899 st063254 59.6 µM -1.30445587412799 0.124061562508167 no 2984 0.0960390975811633 4314 3093813 SGTC_2119 5528445 120.635 µM -1.31072665034913 0.122926942881843 no 2985 0.0949750657346393 4402 791935 SGTC_1506 4226-2149 212 µM -1.31133417044723 0.122817407448014 no 2986 0.0948724443470221 4375 991114 SGTC_1979 st071809 45.3 µM -1.31546538674313 0.122074367345115 no 2987 0.0941767714054199 4418 4976333 SGTC_369 0957-0393 4.5 µM -1.31564758625912 0.12204166979919 no 2988 0.0941461769327297 4380 6997992 SGTC_1753 st043925 64 µM -1.31622275158065 0.121938490920258 no 2989 0.0940496447639859 4403 670181 SGTC_3142 9086498 49.47 µM -1.31714188491387 0.121773734855643 no 2990 0.0938955347805028 4242 25236367 SGTC_1618 st003135 44.5 µM -1.32061686112632 0.121152253737144 no 2991 0.0933145739418722 4350 1270615 SGTC_2923 7992654 58.14 µM -1.32213808364687 0.120880894425717 no 2992 0.0930610871022772 4371 2985126 SGTC_2004 4023728 41.89 µM -1.32373042830971 0.120597306669105 no 2993 0.092796294506273 4352 360084 YDR527W RBA50 SGTC_666 0272-0154 136 µM -1.32563158683594 0.12025933479592 no 2994 0.0924808791301484 4376 6870312 SGTC_3178 9107506 49.47 µM -1.32883273810128 0.119691770009743 no 2995 0.0919515793413121 4385 8897194 SGTC_1653 st012112 65 µM -1.33138544832873 0.119240529766067 no 2996 0.0915311075120443 4381 720429 SGTC_3343 9148379 18.9835 µM -1.33198607734212 0.11913453184898 no 2997 0.0914323817965311 4397 1955036 SGTC_441 propafenone 146 µM -1.33209104176328 0.119116014748774 no 2998 0.0914151368430009 4377 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3011 9081274 71.4286 µM -1.3320925587017 0.119115747155842 no 2999 0.0914148876378221 4381 6625322 SGTC_2747 doxorubicin 7.63 µM -1.33317348121482 0.118925176747529 no 3000 0.0912374398777834 4417 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2926 9010726 65.15 µM -1.33486898959875 0.118626686638158 no 3001 0.0909596144001419 4385 2994293 SGTC_1106 tegaserod maleate 11.7 µM -1.3361469934252 0.118402047342436 no 3002 0.0907506162603405 4414 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_128 0906-2981 13.371 µM -1.33874574004481 0.117946184162208 no 3003 0.0903267301399392 4376 6740226 SGTC_554 4483-2211 187 µM -1.3405655921357 0.117627692078242 no 3004 0.0900307674400076 4452 747107 SGTC_685 1278-0033 54.9 µM -1.34095896299688 0.117558928385136 no 3005 0.0899668883189811 4469 3590572 SGTC_961 1252-1571 372 µM -1.34204680859942 0.11736891433583 no 3006 0.0897904094727455 4411 6813498 SGTC_1834 st055981 52.8 µM -1.3425403572913 0.11728277792173 no 3007 0.0897104270444727 4397 471719 YDL150W RPC53 SGTC_2955 9076254 12.21 µM -1.35128920673478 0.115763314734368 no 3008 0.0883014040563895 4316 16459619 SGTC_2463 5473429 200 µM -1.35278009099964 0.115505784831978 no 3009 0.0880629474411885 4400 5399405 SGTC_3218 9131285 49.47 µM -1.35313595720705 0.11544437402869 no 3010 0.0880061001482177 4384 17156417 SGTC_1010 4112-3296 15.2 µM -1.3554609158453 0.11504373355314 no 3011 0.087635376443129 4437 704384 SGTC_3049 9092223 49.47 µM -1.35723138730383 0.114739307019144 no 3012 0.0873538503079386 4393 8623917 SGTC_3345 9148410 3.559 µM -1.35865307251075 0.114495268342537 no 3013 0.0871282745178615 4355 4903596 SGTC_109 0132-0036 33.701 µM -1.35911588680932 0.114415903953337 no 3014 0.0870549346874377 4282 67274 A color developer. SGTC_1176 0848-0131 83.3 µM -1.35978876707656 0.11430058687662 no 3015 0.08694838903305 4468 6769040 SGTC_1171 0368-0077 21.4 µM -1.36008905998609 0.114249149905418 no 3016 0.0869008713028321 4380 3239779 SGTC_1124 fisetin 1.16336 µM -1.36107055427567 0.114081145398407 no 3017 0.0867456970044515 4419 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2600 tangeritin 87.95 µM -1.36486010129365 0.113434132070351 no 3018 0.0861485122671541 4313 68077 A bioactive flavone. SGTC_3207 9114163 49.47 µM -1.36526316157953 0.113365469323339 no 3019 0.086085176450861 4403 849233 SGTC_76 0433-0009 400.328 µM -1.36791268451253 0.112914851561156 no 3020 0.0856697044097285 4473 2841569 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.36815174297891 0.112874256652936 no 3021 0.0856322915850613 4450 5393153 SGTC_1559 coumarin 343 70.1 µM -1.36848463601292 0.112817744900774 no 3022 0.0855802139620288 4456 108770 A hepatotoxic, DNA x-linker. SGTC_1152 3909-8331 15.9 µM -1.37407277175155 0.111872120007197 no 3023 0.0847095457456568 4387 16001939 SGTC_1351 1496-0003 46.5 µM -1.37976828301635 0.110914171615256 no 3024 0.0838290005514263 4434 3891978 SGTC_127 0180-0333 59.125 µM -1.37982916299885 0.110903963833086 no 3025 0.0838196255789587 4324 771601 SGTC_2143 5623677 140.463 µM -1.38052989880895 0.11078651950194 no 3026 0.0837117752247837 4364 5375313 SGTC_1742 st038235 28.8875 µM -1.38118580271298 0.110676669831308 no 3027 0.0836109194451967 4450 564103 YBR002C RER2 SGTC_219 mitoxanthrone 164.414 µM -1.3836711022666 0.110261144379389 no 3028 0.0832295929449658 4361 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_424 splitomicin 100 mM -1.38696906938756 0.109711475447516 no 3029 0.0827255973404109 4440 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3302 9125395 16.351 µM -1.38859807248826 0.10944069806599 no 3030 0.082477501912695 4376 17599668 SGTC_3287 9117173 37.0625 µM -1.39225983949815 0.108833781986082 no 3031 0.0819218640550536 4438 2789709 SGTC_1252 0493-0875 34.8 µM -1.39334241447314 0.108654815977189 no 3032 0.0817581351992261 4407 3960963 SGTC_3091 9116372 49.47 µM -1.39376488441823 0.108585032756736 no 3033 0.0816943077143347 4489 17169793 SGTC_1776 st049249 45.9 µM -1.39883577983552 0.107749941382291 no 3034 0.0809311170655517 4451 1822314 SGTC_2981 9013952 38.96 µM -1.40175112185567 0.107271933098487 no 3035 0.0804947894574973 4386 2996344 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.40266650066307 0.107122160686075 no 3036 0.0803581556099769 4273 88881 An O-methylated flavonoid and antioxidant. SGTC_2052 5265182 7.135 µM -1.40283779440163 0.107094150712537 no 3037 0.0803326069587304 4417 1239884 SGTC_2840 9008771 71.43 µM -1.4030557054332 0.107058525507852 no 3038 0.0803001141581381 4388 2992978 SGTC_1408 3909-7976 48.8 µM -1.40694335307829 0.106424389026069 no 3039 0.0797220934028766 4482 24152374 SGTC_2048 5246248 200 µM -1.41258492224178 0.105508990751752 no 3040 0.0788889024586815 4452 677046 SGTC_716 1683-5115 658 µM -1.41577482984101 0.10499392490631 no 3041 0.078420720622439 4429 723597 SGTC_2667 digitoxin 100 µM -1.41679921109712 0.10482890753787 no 3042 0.0782708202176763 4393 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_799 1310-0557 151 µM -1.41885617735768 0.104498118576984 no 3043 0.0779704753279067 4470 5354492 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.42133364779688 0.104100711417326 no 3044 0.0776098930076555 4452 6728940 SGTC_660 4031-1742 102 µM -1.4224367488187 0.103924117697693 no 3045 0.0774497506166414 4329 6738706 SGTC_2876 9059903 25.97 µM -1.42301734846438 0.103831257722358 no 3046 0.077365563087945 4443 6916095 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.42433682860879 0.103620446483267 no 3047 0.0771744956539899 4492 688664 SGTC_3297 9117502 71.43 µM -1.42456126783405 0.103584619114931 no 3048 0.0771420314235146 4474 7453720 SGTC_3098 9119039 49.47 µM -1.42536518253572 0.103456363493553 no 3049 0.0770258335470904 4453 17161528 SGTC_431 k089-0097 107 µM -1.42609533188427 0.10333997623045 no 3050 0.0769204130373385 4182 5499420 SGTC_2861 9024595 19.48 µM -1.42707511821926 0.103183945734448 no 3051 0.0767791217921969 4383 16482810 SGTC_2399 5884133 200 µM -1.4279681230617 0.103041884231634 no 3052 0.0766505169433315 4408 722445 SGTC_1602 st001878 87.6 µM -1.42946808428148 0.102803586363272 no 3053 0.076434870897301 4432 595405 YLR310C CDC25 SGTC_122 0236-0016 402.397 µM -1.43023520156659 0.102681869823805 no 3054 0.076324762717442 4446 6808838 SGTC_972 1319-0219 195 µM -1.43254181179886 0.102316516898013 no 3055 0.0759944104822289 4446 23903702 SGTC_520 3584-0023 682 µM -1.43725416965001 0.101573048917299 no 3056 0.0753228930392403 4456 1340790 SGTC_3 0833-0587 95.581 µM -1.4433568208769 0.100616091320748 no 3057 0.0744599904955188 4341 5382644 SGTC_1324 1418-0026 34.4 µM -1.4444045534501 0.100452459888862 no 3058 0.0743126053126977 4500 1372513 SGTC_1600 coumarin 106 71.1 µM -1.44518296993544 0.100331015138811 no 3059 0.074203249303821 4527 100336 A hepatotoxic, DNA x-linker. SGTC_1934 st074720 32.6 µM -1.44758316796925 0.0999572225762508 no 3060 0.0738668306880164 4398 17250992 SGTC_559 1550-0661 158 µM -1.45031400709615 0.0995331759187161 no 3061 0.0734854873888109 4500 5830875 SGTC_2155 5570423 76 µM -1.45107479666406 0.0994152744596587 no 3062 0.0733795168448071 4442 797402 SGTC_637 1181-0519 7.26 µM -1.45187571737812 0.0992912641195339 no 3063 0.0732680827604973 4479 6252091 YGR060W ERG25 SGTC_3190 9110366 49.47 µM -1.45436154114496 0.0989070925973603 no 3064 0.0729230483140069 4477 17123768 SGTC_1665 st014639 11.4 µM -1.45540933498785 0.0987454875589525 no 3065 0.0727779868083172 4542 981133 YIL048W NEO1 SGTC_940 3232-1287 54.8 µM -1.45604067947613 0.098648206356489 no 3066 0.0726906872423726 4447 1585493 YIL048W NEO1 SGTC_1450 4112-4260 37.6 µM -1.45891669397086 0.0982059410187971 no 3067 0.0722940188881168 4462 1633175 SGTC_1295 1013-0063 9.78 µM -1.4610879396611 0.0978730164591655 no 3068 0.0719956547623469 4489 6826038 SGTC_2061 5245884 80.95 µM -1.46458617141004 0.0973383618911128 no 3069 0.0715169285617415 4443 573863 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.46505406614302 0.0972670136655128 no 3070 0.0714530837176985 4493 390807 SGTC_2284 7945075 39.21 µM -1.46771265764457 0.0968623393139926 no 3071 0.071091145519378 4441 1245402 SGTC_1830 st055982 50.3 µM -1.47299825596843 0.0960614727542661 no 3072 0.0703757530228353 4480 455313 An antimicrobial agent. SGTC_2997 9067075 71.4286 µM -1.47446584718386 0.0958399713766419 no 3073 0.0701781033372779 4446 27209819 SGTC_1578 josamycin 24.2 µM -1.47562668128243 0.0956650346744901 no 3074 0.0700220691912338 4471 5282165 A P450 substrate. SGTC_1044 1222-0021 1.78 µM -1.47804432726719 0.0953014519105015 no 3075 0.0696979569714257 4404 4306703 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.4818933366082 0.0947247113555453 no 3076 0.0691843391709876 4464 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2096 5468907 200 µM -1.48485021756352 0.0942833985988285 no 3077 0.0687917529242442 4477 759785 SGTC_261 5-fluorouridine 15.376 µM -1.48508638692538 0.094248215965434 no 3078 0.0687604708500861 4505 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2207 7258803 200 µM -1.48781122492295 0.0938429914519619 no 3079 0.0684003422934172 4505 3666799 SGTC_58 0957-0393 9 µM -1.4897304445777 0.0935583474046877 no 3080 0.0681475631120048 4074 6997992 SGTC_455 paf C-16 10 µM -1.49267119942684 0.0931234347761962 no 3081 0.0677616379226392 4455 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_53 0973-0023 39.979 µM -1.49269704461735 0.093119619127085 no 3082 0.0677582536701474 4393 674768 SGTC_3107 9121808 49.47 µM -1.49286415676215 0.0930949503505841 no 3083 0.0677363746187873 4451 662681 SGTC_1917 st066507 28.5 µM -1.49377888940132 0.0929600048336597 no 3084 0.0676167105070778 4444 3156428 SGTC_767 0929-0023 86 µM -1.49902478131976 0.0921888986567819 no 3085 0.0669336016560173 4522 1204563 SGTC_1161 k007-0610 110 µM -1.49971044617331 0.0920884620528887 no 3086 0.066844711729166 4427 5843850 SGTC_1641 st009299 47.1 µM -1.50388283824282 0.0914790334256389 no 3087 0.0663057683118543 4427 4046054 SGTC_1962 st076595 64.5 µM -1.50818128044829 0.0908543249619292 no 3088 0.0657540684778302 4466 279619 SGTC_3048 9093155 49.47 µM -1.51242050402742 0.0902413286876505 no 3089 0.0652134610105018 4472 25236002 SGTC_696 1560-0013 611 µM -1.51258545470265 0.090217538887459 no 3090 0.0651924955713313 4535 1650269 SGTC_3316 9136639 10.545 µM -1.51909918370364 0.0892818248820166 no 3091 0.0643687660912332 4493 4903665 SGTC_409 arachidonic acid 100 µM -1.52092846826937 0.0890203465960934 no 3092 0.0641388944996342 4514 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2162 5663267 200 µM -1.52649569237141 0.0882280739252221 no 3093 0.0634432312095846 4515 6456493 SGTC_2080 5212524 12.4 µM -1.52681031319408 0.0881834575846505 no 3094 0.063404093166886 4455 260183 SGTC_1166 k206-0078 225 µM -1.53134188822518 0.0875426999363303 no 3095 0.0628424590513841 4532 5404595 SGTC_2912 7964298 10.93 µM -1.53410700597354 0.0871534271603881 no 3096 0.0625016650205585 4503 2975850 SGTC_1868 st057644 42.7 µM -1.53433374778122 0.087121563924538 no 3097 0.0624737836889655 4536 688665 SGTC_1276 0871-0068 94.2 µM -1.53451729296365 0.0870957773319148 no 3098 0.0624512211380474 4524 3414906 SGTC_2891 9063876 19.48 µM -1.54599709475321 0.0854942638256505 no 3099 0.061052634732725 4543 6472478 SGTC_1153 4055-0057 267 µM -1.54639117211793 0.0854396814242287 no 3100 0.0610050624367799 4554 882706 SGTC_51 1013-0126 23.419 µM -1.54951156123742 0.0850084074744771 no 3101 0.0606293972420261 4503 1627850 SGTC_1935 st074532 41.6 µM -1.55116116737206 0.0847810731206562 no 3102 0.0604315328243731 4477 2829742 SGTC_699 0375-0592 111 µM -1.55150229757492 0.0847341184614299 no 3103 0.0603906785834655 4593 762578 SGTC_2116 5511452 16.8835 µM -1.55265259531542 0.0845759301754277 no 3104 0.0602530765866379 4526 870744 SGTC_2374 9071832 200 µM -1.55529546650643 0.0842133233488947 no 3105 0.0599378582875759 4465 17381698 SGTC_659 k018-0002 107 µM -1.55762968527411 0.083894035717988 no 3106 0.05966052875319 4497 6797879 YHR007C ERG11 SGTC_2603 homopterocarpin 100 µM -1.56103340631844 0.083430086088941 no 3107 0.0592579344915218 4513 101795 A weak amylase inhibitor. SGTC_3101 9120531 49.47 µM -1.56312101001376 0.08314648757528 no 3108 0.0590120673644736 4502 24824904 SGTC_1248 0469-0687 58.6 µM -1.56362306364526 0.0830783924348035 no 3109 0.0589530576331003 4481 4017482 SGTC_3176 9106582 49.47 µM -1.56520497383199 0.082864107165189 no 3110 0.0587674278305703 4549 17018027 SGTC_953 1188-0045 9.7 µM -1.56681112206717 0.0826469643151565 no 3111 0.0585794234598838 4507 6144426 SGTC_2486 5283202 22.39 µM -1.57791195271915 0.0811578840571888 no 3112 0.0572929193295258 4536 1377751 SGTC_1840 st055363 71 µM -1.57879390436604 0.0810404516489222 no 3113 0.0571916686149004 4558 676033 SGTC_110 0850-0284 111.64 µM -1.57967912671069 0.0809227127488581 no 3114 0.0570901840842056 4450 3906265 SGTC_2089 5281248 129.67 µM -1.58049447575034 0.0808143816231514 no 3115 0.0569968355050169 4517 2737878 SGTC_2763 lisinopril 49.32 µM -1.58295538769675 0.0804880772110091 no 3116 0.0567158165181135 4446 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2525 harmine 47.85 µM -1.58557266213796 0.0801421331683244 no 3117 0.0564181408853289 4553 5280953 A monoamine oxidase inhibitor SGTC_2867 9039098 71.43 µM -1.58589858224227 0.0800991327723162 no 3118 0.0563811587482551 4515 6463460 SGTC_2035 5154463 94.595 µM -1.58859831268918 0.0797436131585353 no 3119 0.0560755546939989 4552 2769623 SGTC_2551 apiole 73.87 µM -1.59479820569474 0.0789316870760119 no 3120 0.055378684218254 4481 10659 A possible DNA adduct former. SGTC_3320 9137005 35.139 µM -1.59781961235735 0.0785382860523688 no 3121 0.0550415642778027 4578 4908713 SGTC_1296 1068-0102 11.9 µM -1.60090967791429 0.0781374844823453 no 3122 0.0546984628751308 4554 767053 SGTC_79 0052-0007 94.094 µM -1.60582803980358 0.0775027438131439 no 3123 0.0541558489812729 4525 2801472 SGTC_3024 9090631 49.47 µM -1.60680777769097 0.0773767724328824 no 3124 0.0540482707848136 4521 25236383 SGTC_1567 st069303 68.4 µM -1.60804201262338 0.0772183001217333 no 3125 0.0539129888861287 4553 5581319 SGTC_2644 guaiazulene 100 µM -1.60815270151854 0.0772041000351627 no 3126 0.0539008696199486 4585 3515 A coloring agent. SGTC_3045 9092950 49.47 µM -1.61014951408307 0.076948273024317 no 3127 0.0536826099375639 4524 44120432 SGTC_2685 mycophenolic acid 18.85 µM -1.61024005961451 0.0769366878304024 no 3128 0.0536727295604985 4555 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.61508406431758 0.0763188340410623 no 3129 0.0531462457171143 4583 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1715 st032160 10.2275 µM -1.61710798581805 0.076061803621388 no 3130 0.0529274866867454 4451 5289825 SGTC_1508 1080-0625 72.9 µM -1.61839949672902 0.0758981313619333 no 3131 0.0527882652053627 4505 767111 SGTC_3065 9113888 49.47 µM -1.61967560602687 0.0757366744961847 no 3132 0.0526509894937111 4567 16648368 SGTC_3100 9120536 49.47 µM -1.62134621557964 0.0755256999842641 no 3133 0.0524717043194633 4451 16421196 SGTC_3173 9105693 49.47 µM -1.62198300222092 0.0754454007662696 no 3134 0.0524034938476395 4539 17096658 SGTC_3245 9134821 49.47 µM -1.62241941912997 0.0753904058917742 no 3135 0.0523567869854573 4556 17014901 SGTC_435 c-PAF 6.7 µM -1.62735925730677 0.0747700429944022 no 3136 0.0518304096592773 4476 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2524 avocatin b 10.57 µM -1.63009924155321 0.0744276292617133 no 3137 0.0515402620039478 4573 6710748 SGTC_1693 xanthone 101.9 µM -1.63155876771461 0.0742457227714036 no 3138 0.0513862351277481 4616 7020 An insecticide. SGTC_2193 5925765 200 µM -1.63463252414069 0.0738637391503128 no 3139 0.0510630526491815 4589 877370 SGTC_1676 st018489 23.4 µM -1.63568772499917 0.0737329534926255 no 3140 0.0509524799027684 4526 3696235 SGTC_251 melphalan 456.522 µM -1.63764890566897 0.0734903475370564 no 3141 0.0507474774175612 4595 460612 A DNA alkylator. SGTC_616 4092-0450 108 µM -1.63823604175809 0.0734178352965062 no 3142 0.0506862319193152 4570 787165 SGTC_3219 9131112 49.47 µM -1.63875146617026 0.0733542246764307 no 3143 0.0506325153634365 4428 17612988 YMR079W SEC14 SGTC_3177 9107506 49.47 µM -1.64035749523065 0.0731562884217548 no 3144 0.0504654287719616 4538 8897194 SGTC_892 0929-0076 29 µM -1.64438213284008 0.0726620643652515 no 3145 0.0500486467065754 4545 5751038 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.6452405926349 0.0725569774420687 no 3146 0.0499601027461184 4577 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1143 3454-2408 5.08 µM -1.64592575717102 0.0724731877344795 no 3147 0.0498895226263208 4567 X1143 SGTC_2064 5220758 200 µM -1.6486277512399 0.072143479608927 no 3148 0.0496119598970669 4583 788518 SGTC_1976 st070609 63.5 µM -1.64864588416166 0.0721412708476373 no 3149 0.0496101013612983 4516 682556 SGTC_726 3448-4391 34.2 µM -1.65046228642366 0.0719202784358069 no 3150 0.0494242103748041 4630 1356692 SGTC_333 3486-0131 40.1 µM -1.65181965164819 0.0717554739067527 no 3151 0.0492856606736616 4578 6744690 SGTC_3069 9117009 49.47 µM -1.65687111878749 0.0711446940335151 no 3152 0.0487727672926063 4573 41904981 SGTC_3139 9095020 49.47 µM -1.66319946366033 0.0703851677892276 no 3153 0.0481362574892209 4456 25236292 SGTC_4 0960-0234 25.671 µM -1.67635609878425 0.0688260834970455 no 3154 0.0468342313136789 4555 6821112 SGTC_2877 9040724 71.43 µM -1.67663414449087 0.0687934242474464 no 3155 0.0468070228241759 4539 6463895 SGTC_865 0488-0499 301 µM -1.68165151350544 0.0682061352077831 no 3156 0.046318217632123 4518 9634651 SGTC_3158 9100007 49.47 µM -1.68577171305399 0.0677267608254107 no 3157 0.0459198890525058 4592 19297233 SGTC_1112 tnp00069 1.16933 µM -1.68585463294269 0.067717140099638 no 3158 0.0459119009489011 4560 145826 SGTC_117 lucigenin 22.078 µM -1.69048618448127 0.0671814418881398 no 3159 0.0454674895745438 4544 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2491 paeonol 100 µM -1.69364077390237 0.0668184532631881 no 3160 0.0451667825467817 4574 11092 Increases levels of cortical cytochrome oxidase. SGTC_1338 1486-1223 76 µM -1.6938073895447 0.0667993236010874 no 3161 0.0451509447314909 4591 3444526 SGTC_1332 1480-0653 17.5 µM -1.69468132209531 0.0666990540734223 no 3162 0.0450679453830904 4590 5749438 SGTC_1513 0337-0559 19 µM -1.69548377877347 0.0666070878505461 no 3163 0.0449918424382874 4562 775073 SGTC_2965 9082772 38.63 µM -1.69997767339678 0.0660938740397377 no 3164 0.044567562594826 4561 16459634 SGTC_116 0155-0182 31.788 µM -1.70379340745598 0.0656605172936624 no 3165 0.044209845026387 4444 771486 SGTC_482 fipronil 114 µM -1.70664645378919 0.0653379357669281 no 3166 0.0439438926652702 4698 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_779 1360-0071 233 µM -1.7078523722513 0.0652019580108928 no 3167 0.0438318692327329 4598 7566 SGTC_2160 5660466 132.927 µM -1.7091334971936 0.0650577407238837 no 3168 0.0437131119966921 4546 2859134 SGTC_3235 9132602 49.47 µM -1.70980463263863 0.0649822893373251 no 3169 0.0436510030384896 4568 4912240 SGTC_858 0438-0351 2.77 µM -1.71612619464793 0.0642749264190873 no 3170 0.0430694739212812 4587 2799119 SGTC_1428 4049-0204 61.7 µM -1.71802776616336 0.0640633215253842 no 3171 0.0428957754245703 4633 X1428 SGTC_851 0394-0702 453 µM -1.71907380221375 0.0639471508639352 no 3172 0.0428004671850234 4603 762646 SGTC_2327 6189656 200 µM -1.72379434825597 0.0634249331509254 no 3173 0.0423724876364122 4633 5349088 SGTC_1675 st018485 24.5 µM -1.72437582973477 0.0633608361519786 no 3174 0.0423200090127547 4585 3323024 SGTC_3168 9103419 49.47 µM -1.72521275701383 0.0632686697645226 no 3175 0.0422445687568044 4644 16649256 SGTC_936 3005-4620 401 µM -1.72528425504414 0.0632608009055365 no 3176 0.0422381290039381 4603 777207 SGTC_3234 9132280 49.47 µM -1.73391513254879 0.0623164979231134 no 3177 0.0414665712275864 4618 17612295 SGTC_102 gallobenzophenone 83.616 µM -1.73557081605795 0.0621366129822607 no 3178 0.041319874951265 4582 70837 SGTC_2646 retinol 96.75 µM -1.73601046293427 0.0620889148269122 no 3179 0.0412809922769205 4626 445354 A vitamin A analog and teratogen. SGTC_1462 k081-0014 26.5 µM -1.73799129625471 0.0618743645391963 no 3180 0.0411061737105045 4033 3270634 SGTC_856 0433-0016 11.3 µM -1.73849227386861 0.0618201938641836 no 3181 0.0410620551461837 4625 3911780 SGTC_1498 4478-3555 97.6 µM -1.7413884594778 0.0615077548149609 no 3182 0.0408077548648857 4625 3437919 SGTC_198 3454-2873 16.191 µM -1.74205263569729 0.0614362779539208 no 3183 0.040749617197348 4604 710957 SGTC_2602 kawain 100 µM -1.74646282303603 0.0609633099394914 no 3184 0.0403652808565394 4570 5369129 SGTC_3328 9140624 29.0385 µM -1.75011126395691 0.060574190538097 no 3185 0.040049558242466 4598 4904392 SGTC_309 k408-0051 1.48 µM -1.75202598193542 0.0603707578161019 no 3186 0.0398846701951739 4533 3640463 SGTC_2745 rifampicin 24.3 µM -1.75550578830654 0.0600024086917347 no 3187 0.0395864157232019 4719 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_620 0109-0052 432 µM -1.75609160385264 0.0599405716103907 no 3188 0.0395363842666684 4646 493037 SGTC_862 0452-0056 10.2 µM -1.75799189774848 0.0597403253049221 no 3189 0.0393744439650114 4573 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1079 idarubicin 2.36 µM -1.76003061500844 0.0595260756115672 no 3190 0.039201307928389 4635 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_607 4491-0986 66.8 µM -1.76147656605188 0.0593744853574749 no 3191 0.0390788879483855 4609 698981 YDR232W HEM1 SGTC_807 1315-0151 48 µM -1.77762992454347 0.0577015086970086 no 3192 0.0377323278322546 4609 4011080 SGTC_2582 agaric acid 100 µM -1.78038053641759 0.0574203619366745 no 3193 0.0375068524440412 4257 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_623 k072-0108 16.9 µM -1.79741100053625 0.0557035594411843 no 3194 0.0361351978188025 4596 5382803 SGTC_255 tunicamycin 200.472 nM -1.79808359578708 0.0556365973326146 no 3195 0.0360818806938513 4550 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1774 st048371 48.465 µM -1.801916805209 0.0552561834418102 no 3196 0.0357792478973817 4617 4242727 SGTC_842 0271-0008 11.1 µM -1.80266151762867 0.0551825158624442 no 3197 0.0357206946508105 4641 1221709 SGTC_1373 2887-0003 58.5 µM -1.80487382463719 0.054964130083365 no 3198 0.0355472143303969 4592 776948 SGTC_2829 7992743 58.44 µM -1.80544867982445 0.0549074957357667 no 3199 0.0355022497046801 4597 16462845 SGTC_1882 5615643 20 µM -1.8074557722492 0.0547101198788092 no 3200 0.0353456223537325 4621 2253075 SGTC_373 0844-0104 25.9 µM -1.80925935097657 0.0545332362821762 no 3201 0.0352053604534782 4639 5375804 SGTC_2641 levomentholum 100 µM -1.81514243922734 0.0539594023094166 no 3202 0.0347510113584676 4642 16666 SGTC_848 0368-0089 85.6 µM -1.8184971634709 0.053634330321274 no 3203 0.0344940899322021 4631 762535 SGTC_1330 1469-0054 61.8 µM -1.82090130006563 0.0534023257246091 no 3204 0.0343109307742978 4598 7102664 SGTC_2780 5215298 71.43 µM -1.82445938476928 0.0530604228715407 no 3205 0.034041325605516 4642 2834131 SGTC_2475 5812728 15.03 µM -1.82481552369403 0.0530262966149667 no 3206 0.0340144362244651 4596 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3248 9135562 49.47 µM -1.8255958354318 0.0529515857460371 no 3207 0.0339555817923329 4612 17650701 SGTC_885 0865-0106 16.8 µM -1.8291495263374 0.0526123932999435 no 3208 0.0336886056567988 4605 2793380 SGTC_235 0330-0087 5 mM -1.83489193365721 0.0520679392663882 no 3209 0.0332608515465237 4667 46494818 YHR062C RPP1 SGTC_3315 9136395 68.55 µM -1.83736080522455 0.0518352386202547 no 3210 0.0330783244717978 4643 16876844 SGTC_1814 st052110 31.539 µM -1.84105482811573 0.0514886070993895 no 3211 0.032806762197951 4585 674163 SGTC_311 1315-0136 58 µM -1.84568414421507 0.0510568169840309 no 3212 0.0324690403903163 4657 6759207 SGTC_3230 9131665 49.47 µM -1.84798058665485 0.0508436929355684 no 3213 0.0323025756457501 4672 15943720 SGTC_3300 9124615 50.48 µM -1.85259872342897 0.0504172460775172 no 3214 0.0319699477870032 4635 24824903 SGTC_3309 9129340 25.759 µM -1.85449684340909 0.0502427988736889 no 3215 0.0318340556676552 4619 17158987 SGTC_1216 1165-0504 9.65 µM -1.85761101367372 0.0499576327854937 no 3216 0.0316121366810711 4674 6304004 SGTC_1759 st043059 70 µM -1.85883623686282 0.0498457929267792 no 3217 0.0315251771890696 4664 669426 SGTC_1496 4469-0713 57.4 µM -1.86353874135042 0.0494183956896891 no 3218 0.0311932535904463 4666 746691 SGTC_2282 7944268 200 µM -1.86537812386152 0.0492520174703531 no 3219 0.0310642107565572 4625 2970414 SGTC_1996 st072960 66.8 µM -1.86854666285908 0.0489664618423536 no 3220 0.0308429561522687 4670 1719405 SGTC_2545 solidagenone 89.61 µM -1.8775678925314 0.0481606884333321 no 3221 0.030220150745884 4617 6708572 An anti ulcer agent SGTC_2915 7971052 15.16 µM -1.87822361380905 0.0481025356792339 no 3222 0.0301752905408685 4613 5741558 SGTC_71 0417-1750 47.813 µM -1.87823267907031 0.0481017321189396 no 3223 0.0301746707414392 4607 6811472 SGTC_1751 st044839 27.194 µM -1.89224235421426 0.0468726700890448 no 3224 0.029229348790311 4683 5291326 SGTC_793 0488-0545 106 µM -1.89474342705141 0.04665592519354 no 3225 0.0290632006950341 4677 292548 SGTC_301 4119-0100 24.5 µM -1.89588679908683 0.0465571079099264 no 3226 0.0289875074426481 4661 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2572 astragaloside iv 100 µM -1.90551124180156 0.0457319464033706 no 3227 0.0283568237704036 4616 45006101 An anti-inflammatory agent. SGTC_2460 5552655 174.22 µM -1.90861306436748 0.045468527275002 no 3228 0.0281560126758143 4636 5401989 SGTC_1133 3473-0247 50 µM -1.9093341097212 0.0454074683537078 no 3229 0.028109502390147 4629 711311 SGTC_1507 4075-3230 155 µM -1.91292374231545 0.0451044749870159 no 3230 0.0278789078018262 4628 659771 SGTC_1560 lithocholic acid 53.1 µM -1.91343460118705 0.0450614870158753 no 3231 0.0278462191625323 4613 9903 A bile acid which acts as a detergent. SGTC_3292 9120825 59.784 µM -1.91549637938034 0.0448883265942371 no 3232 0.02771461522062 4638 24824900 SGTC_305 1682-2595 20.8 µM -1.91689045860583 0.0447715473687655 no 3233 0.0276259247458454 4666 226033 SGTC_2312 7706453 155.7 µM -1.92618454053649 0.0439992398110988 no 3234 0.0270406677261261 4642 976098 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.92810370073533 0.043841109943757 no 3235 0.0269211143868768 4613 676296 Flavone; oxidizing agent. SGTC_2318 6029776 164 µM -1.93322135175028 0.043421679624325 no 3236 0.0266044677713087 4653 818325 SGTC_3071 9117417 49.47 µM -1.93324050553353 0.0434201159329584 no 3237 0.0266032885305456 4636 45595590 YGL055W OLE1 SGTC_3259 9138485 49.47 µM -1.93794937241646 0.0430370670653673 no 3238 0.0263146997697817 4634 17646153 SGTC_2983 9022671 12.99 µM -1.93888744065255 0.0429610857614777 no 3239 0.0262575227937045 4656 6405161 SGTC_2611 pyromycin 23.93 µM -1.94202236898752 0.0427079500590271 no 3240 0.026067196188055 4608 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_366 0181-0206 4.31 µM -1.94306051424906 0.0426243893080458 no 3241 0.0260044235698371 4640 274874 SGTC_2998 9066762 71.4286 µM -1.94361870419027 0.0425795150381724 no 3242 0.0259707242927614 4660 4945196 SGTC_601 0986-0029 62.9 µM -1.9465649560672 0.0423432911240288 no 3243 0.0257934566935197 4636 24747981 SGTC_138 0850-0259 40.9225 µM -1.95388011879286 0.0417613596859104 no 3244 0.0253576981445302 4610 6813004 SGTC_2412 st077135 33.4 µM -1.95484464758251 0.0416851156951297 no 3245 0.025300704766004 4652 13258915 SGTC_1866 st057638 64 µM -1.96283136691755 0.0410581054817988 no 3246 0.0248328858937677 4693 688802 SGTC_2220 6782180 200 µM -1.96949346788672 0.0405409567753753 no 3247 0.0244482259752651 4668 833803 SGTC_588 3970-1144 52.9 µM -1.97238079117556 0.0403184754513183 no 3248 0.0242830764893842 4612 1888707 SGTC_3266 9136860 49.47 µM -1.97471219890177 0.0401395543927343 no 3249 0.0241504088860576 4436 4871271 YPR165W RHO1 SGTC_1081 sertraline 6 µM -1.97572830569554 0.0400617766015468 no 3250 0.0240927786245193 4667 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_420 mitomycin C 81.9 mM -1.97631129687329 0.0400172069146625 no 3251 0.0240597654590961 4662 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2746 daunorubicin 9.88 µM -1.9786531060323 0.0398385813903201 no 3252 0.0239275380471767 4709 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_354 2783-3500 4.88 µM -1.98238911661895 0.0395549530358309 no 3253 0.0237178533703728 4672 6740761 SGTC_1221 2958-7315 257 µM -1.99234363849862 0.038807242289126 no 3254 0.023166683380506 4702 4562705 SGTC_3277 9138724 49.47 µM -1.99372553191133 0.0387043605786812 no 3255 0.0230910287876475 4681 15943418 SGTC_2003 4023581 200 µM -1.99430834657052 0.0386610368061831 no 3256 0.0230591838330218 4661 16641307 SGTC_25 0118-0223 35.662 µM -1.99678370879628 0.0384774697942681 no 3257 0.0229243420286286 4666 5333628 SGTC_1275 0867-0008 21.1 µM -2.02259076649205 0.0366056761254521 no 3258 0.0215576784813381 4666 3422836 SGTC_1470 k295-0292 231 µM -2.03221750635348 0.0359268066422876 no 3259 0.0210658206969461 4734 5045612 SGTC_272 doxorubicin 8.13 µM -2.03292823078679 0.0358770985066174 no 3260 0.0210298871944261 4713 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1312 1218-2183 165 µM -2.03346636364557 0.0358394989370274 no 3261 0.0210027142616591 4735 6744073 SGTC_382 3229-0966 23.2 µM -2.04132010601973 0.0352944194131459 no 3262 0.0206095099314383 4703 5722370 SGTC_3084 9116877 49.47 µM -2.04865153324106 0.0347917450476882 no 3263 0.0202481008243545 4664 27241325 SGTC_1689 st020265 53.493 µM -2.06308772736492 0.0338191184903016 no 3264 0.0195521469894893 4689 5758320 YPR016C TIF6 SGTC_384 k007-0144 5.16 µM -2.06467911640975 0.0337132823627702 no 3265 0.0194766859154154 4679 6824886 SGTC_2744 captopril 92.04 µM -2.06715212236456 0.0335493548243511 no 3266 0.0193599109976944 4734 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3081 9117243 49.47 µM -2.06945556759434 0.0333972576364815 no 3267 0.019251678355907 4660 45595589 SGTC_2406 ethylparaben 405.7 µM -2.07466655234293 0.0330552691600089 no 3268 0.0190087246770704 4658 8434 A possible steroid mimic. SGTC_563 tetrahydrosecaminediol 614 µM -2.08050778287521 0.0326753541802669 no 3269 0.0187394912604171 4740 334274 A psychoactive constituent of the cannabis plant. SGTC_1103 duloxetine 36.1 µM -2.08159978920631 0.0326047308680276 no 3270 0.0186895203444218 4725 60835 A selective serotonin reuptake inhibitor. SGTC_2886 9058944 51.95 µM -2.08474384738128 0.0324020979615545 no 3271 0.0185462791208923 4703 4949929 SGTC_2663 amphotericin b 100 µM -2.10806184985536 0.0309314777635875 no 3272 0.0175128199177928 4717 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2517 totarol 10 µM -2.1172058038612 0.0303700692302589 no 3273 0.0171211925230005 4710 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2986 9022445 71.43 µM -2.12529933536878 0.029880222078702 no 3274 0.0167808218531973 4697 6459286 SGTC_565 1418-0001 44.5 µM -2.12841101987757 0.0296936451316495 no 3275 0.0166515101341438 4732 2862145 SGTC_1323 1348-1351 11.2 µM -2.13771938606175 0.0291412776259892 no 3276 0.0162697625684748 4705 6989654 SGTC_3271 9137798 49.47 µM -2.1412738458587 0.0289326170915056 no 3277 0.0161259804855938 4714 6498326 SGTC_2879 9041815 71.43 µM -2.14319215905845 0.028820521593695 no 3278 0.0160488358197931 4744 4942971 SGTC_1116 jasmonic acid  1.58368 µM -2.15234306003148 0.0282907519241255 no 3279 0.0156851723739146 4751 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1056 3448-1962 115 µM -2.16763449933308 0.0274235886572062 no 3280 0.0150932533493003 4686 715507 SGTC_1958 st076513 41.9 µM -2.17938488202156 0.0267723945206431 no 3281 0.0146515441294244 4670 732122 YGL099W LSG1 SGTC_3251 9135047 49.47 µM -2.18196041133039 0.0266314000852908 no 3282 0.0145562273125524 4749 17682963 SGTC_2976 9009005 19.48 µM -2.19114310119234 0.0261337425673981 no 3283 0.0142207192748542 4693 2993148 SGTC_1454 4239-0054 42.6 µM -2.19192046404874 0.0260919726544191 no 3284 0.0141926250783912 4744 1340767 SGTC_2787 5284540 71.43 µM -2.19256853545631 0.0260571926283816 no 3285 0.0141692400864349 4711 736958 SGTC_176 1486-1328 72.834 µM -2.19347913930893 0.0260083888091527 no 3286 0.0141364379786031 4721 22310231 SGTC_2899 9053889 58.44 µM -2.21010854583853 0.0251304985830019 no 3287 0.0135488149556578 4740 6470052 SGTC_1435 4092-0789 56.7 µM -2.21530244939777 0.0248614479297308 no 3288 0.0133696559232163 4744 2248285 SGTC_2302 7771753 200 µM -2.21882658245893 0.0246802724465756 no 3289 0.013249262404047 4687 2203047 SGTC_536 3852-0578 10.6 µM -2.2269734983462 0.0242656768027828 no 3290 0.0129745225162614 4727 2869208 SGTC_2662 daunorubicin 22.37 µM -2.22827074945908 0.0242002027079679 no 3291 0.0129312328324569 4644 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1343 1487-0095 224 µM -2.23887065044932 0.0236707503658121 no 3292 0.0125821668225909 4716 4560101 YGL055W OLE1 SGTC_2390 9097792 176.6 µM -2.2435236136289 0.0234414356228889 no 3293 0.0124315344360879 4747 4497149 SGTC_539 4859-0462 2.54 µM -2.24506467480764 0.0233658998366111 no 3294 0.0123819904789465 4716 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_882 0843-0131 351 µM -2.246304127378 0.0233052962426478 no 3295 0.0123422671916877 4741 5425421 SGTC_1230 0170-0365 3.77 µM -2.26364832647977 0.0224710298581592 no 3296 0.011797876507586 4732 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_655 k060-0012 42 µM -2.27140570588378 0.0221061273261228 no 3297 0.0115612146603459 4745 5994525 SGTC_514 4466-0038 2.65 nM -2.29007928401028 0.0212481951818218 no 3298 0.0110083605128856 4581 5722064 SGTC_3324 9138759 60.749 µM -2.29535168080475 0.0210111219882566 no 3299 0.0108564890395219 4730 45595710 SGTC_123 0083-0120 66.675 µM -2.29915491826919 0.0208415025306364 no 3300 0.0107480719606309 4719 16001701 SGTC_2716 st080858 38.6235 µM -2.30593425924775 0.0205420272395246 no 3301 0.0105571529923403 4728 5296050 SGTC_2953 9074162 66.49 µM -2.30783407060747 0.0204587605508117 no 3302 0.0105041835749098 4719 16451992 SGTC_2995 9067767 71.4286 µM -2.30857550755568 0.0204263418469973 no 3303 0.0104835741803802 4719 11673567 SGTC_2211 7117706 200 µM -2.32260927319045 0.0198208894371813 no 3304 0.0101000760530842 4729 822771 SGTC_2707 st078556 66.6 µM -2.32492797797478 0.0197223353966761 no 3305 0.0100379058294156 4706 17250899 SGTC_2067 5224629 34.075 µM -2.37827095971914 0.0175673039576581 no 3306 0.0086970195514334 4725 2835000 SGTC_1 0258-0098 57.368 µM -2.38994037192154 0.0171236468743881 no 3307 0.00842555420713015 4685 6790032 YDR047W HEM12 SGTC_2898 9056270 58.44 µM -2.39663503205915 0.0168734726954131 no 3308 0.00827319776697434 4766 19154699 SGTC_2640 pentamidine 10.38 µM -2.39702465132157 0.0168590096781699 no 3309 0.00826440583162373 4712 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1927 st060202 13.8 µM -2.40295278419825 0.0166402565053446 no 3310 0.00813164356021965 4717 688887 SGTC_1501 4491-0275 38.4 µM -2.40551855891796 0.0165463329854278 no 3311 0.00807476582642552 4767 5104718 SGTC_586 0957-0265 8.15 µM -2.43169616318379 0.0156137204687318 no 3312 0.00751415403571338 4704 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2010 4012422 159 µM -2.44399280379344 0.0151914410117611 no 3313 0.00726285813568915 4719 952393 SGTC_760 0568-0725 82.9 µM -2.45368731047262 0.0148654738725943 no 3314 0.00706999382202069 4753 3916171 SGTC_568 1193-0097 7.48 µM -2.47912880187921 0.0140384925801405 no 3315 0.00658518683858853 4598 3646150 SGTC_1938 st074717 56.4 µM -2.48745770391114 0.0137765185809518 no 3316 0.00643298757172073 4714 17250979 SGTC_1878 temozolomide 1 mM -2.5069905604846 0.0131786274645892 no 3317 0.00608819817054662 4762 5394 DNA alkylating agent. SGTC_3073 9114972 49.47 µM -2.51524513472423 0.012932778784026 no 3318 0.00594748228143687 4762 41905075 SGTC_3260 9137109 49.47 µM -2.521401312251 0.0127520185012253 no 3319 0.00584442290361466 4766 17478346 SGTC_883 0850-0245 24.6 µM -2.5394636451864 0.0122342246182933 no 3320 0.0055511291604983 4769 6823229 YPR165W RHO1 SGTC_100 0086-0128 49.5915 µM -2.56485327707794 0.0115372317925096 no 3321 0.0051609721224632 4755 93297 SGTC_2941 9056145 11.23 µM -2.56635837277916 0.0114970191368202 no 3322 0.00513862925517206 4750 2119517 SGTC_3095 9117207 49.47 µM -2.57032825596774 0.0113915366006213 no 3323 0.00508010955800842 4778 17015229 SGTC_206 4546-0025 72.014 µM -2.58038645622616 0.0111280394459832 no 3324 0.0049344902145702 4766 6620745 YIL048W NEO1 SGTC_2741 miltefosine 3.04 µM -2.62755308728712 0.0099619009925104 no 3325 0.00430007106711365 4795 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3195 9113082 49.47 µM -2.6593453597731 0.00923740350849571 no 3326 0.00391463310503748 4754 17018038 SGTC_1232 0279-0259 161 µM -2.67039099179387 0.00899671225382934 no 3327 0.00378814837073941 4772 1560000 SGTC_2629 bisabolol 100 µM -2.67897060969213 0.00881356533536161 no 3328 0.00369244377633207 4765 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_756 0508-1999 28.3 µM -2.6922651837207 0.00853622349510819 no 3329 0.00354842456002392 4779 6753853 SGTC_344 k064-0035 6.43 µM -2.70487482162992 0.00828027638581329 no 3330 0.00341650665845532 4743 5088750 SGTC_266 formosanin C 406 nM -2.80281541437722 0.0065114755531578 no 3331 0.00253293269234555 4719 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2177 5811945 192 µM -2.81005883157021 0.00639503087265047 no 3332 0.0024766222385489 4766 5343475 SGTC_2 0422-0095 29 µM -2.85051266872219 0.00577796693721384 no 3333 0.00218244057536555 4724 6790840 SGTC_3202 9113761 49.47 µM -2.97520963983859 0.0041949820785003 no 3334 0.00146394191074614 4747 4798415 SGTC_2306 7482397 179.52 µM -2.9810655730598 0.00413124535011361 no 3335 0.00143623639379485 4769 891448 SGTC_3096 9117468 49.47 µM -3.0044805178083 0.00388496612249607 no 3336 0.00133017398002827 4790 41316311 SGTC_1509 1326-1131 80 µM -3.01790129582734 0.0037498141444426 no 3337 0.00127265896444883 4770 768313 SGTC_603 3794-0023 45.9 µM -3.02134300595505 0.00371584123446655 no 3338 0.00125828051868233 4795 3802260 SGTC_1946 st076057 65.1 µM -3.09002567451773 0.00309316133564991 no 3339 0.00100069596955213 4799 953009 SGTC_353 1988-1175 58.3 µM -3.12275033215695 0.00283093057360523 no 3340 0.000895848325638347 4684 2788357 SGTC_1540 guanosine 70.6 µM -3.26917626904672 0.00188647270887569 no 3341 0.000539305424178104 4802 6802 Guanosine is a purine nucleoside SGTC_2296 7971656 126.45 µM -3.32435398965387 0.00161237970695552 no 3342 0.000443118132395074 4791 666570 SGTC_1758 st042942 75.2445 µM -3.33145469837057 0.00157987599111107 no 3343 0.000431966801558597 4800 669317 SGTC_1718 roemerine 11.9335 µM -3.34174985351685 0.00153380962603229 no 3344 0.000416260256138423 4610 235224 An aporphine alkaloid with mutagenic activity. SGTC_1047 2043-3044 82 µM -3.3540944105291 0.00148018966032354 no 3345 0.000398125950183433 4782 669592 SGTC_1451 4152-0210 104 µM -3.57004745155072 0.000780080922501939 yes 3346 0.000178458284045176 4805 659563 SGTC_3205 9113483 49.47 µM -3.62269449973458 0.000663852887990165 yes 3347 0.000145775042276075 4790 17018033 SGTC_2991 9074669 71.4286 µM -3.6227340141008 0.000663771997860447 yes 3348 0.000145752767570388 4782 17333109 SGTC_2175 5807670 165.306 µM -3.66381932603459 0.000584417645386712 yes 3349 0.000124241045640756 4804 241186 SGTC_876 0720-0963 56.8 µM -3.71958326219102 0.000490691896029974 yes 3350 9.97758788837704e-05 4802 765861 SGTC_2584 androsterone 48.74 µM -3.93202791535118 0.000246868394822671 yes 3351 4.21161407513107e-05 4784 2754130 A steroid. SGTC_2636 apigenin dimethyl ether 100 µM -3.9437970414354 0.00023741813514207 yes 3352 4.01007707642652e-05 4797 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3347 9188721 44.724 µM -4.04276364912172 0.000170295591934246 yes 3353 2.6412430983735e-05 4807 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1954 st077032 68.9 µM -4.14821243221694 0.000118567335362124 yes 3354 1.67540701690697e-05 4804 698907 SGTC_1948 st076329 66.6 µM -4.46332313887863 3.82516100044961e-05 yes 3355 4.03491054604734e-06 4805 24208413 SGTC_3150 9097574 49.47 µM -5.38403577581062 9.15367125062404e-07 yes 3356 3.64170087356025e-08 4810 17217476