SGTCid condition conc unit RGC1|YPR115W.score RGC1|YPR115W.strain.pval RGC1|YPR115W.strain.significant RGC1|YPR115W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2350 9023895 38.85 µM 7.14301598558108 1.19580305504911e-12 yes 1 4.56525014324948e-13 7 2997209 SGTC_1672 st016598 6.51 µM 6.95704978794827 4.34377896995644e-12 yes 2 1.73736093979249e-12 22 4665860 YNL267W PIK1 SGTC_3157 9099274 49.47 µM 6.00879409480301 1.87677105499286e-09 yes 3 9.34541602910307e-10 2 17217662 SGTC_541 4513-1321 94 µM 5.91660657284126 3.23573689992676e-09 yes 4 1.64325776609728e-09 5 747515 SGTC_527 4476-4215 268 µM 5.75542691456665 8.22674241076852e-09 yes 5 4.32115532299638e-09 12 4418754 SGTC_362 0310-0100 9.03 µM 5.61488725093686 1.81940234909016e-08 yes 6 9.83452278105496e-09 4 790235 SGTC_2931 9014674 55.67 µM 5.28824857188298 1.07144439409496e-07 yes 7 6.17465431564848e-08 4 2996810 SGTC_491 tetrandrine 80.3 µM 4.83265131641801 1.07547852041751e-06 yes 8 6.73633187422582e-07 3 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_646 4092-0839 27.3 µM 4.71666077041659 1.87576409511588e-06 yes 9 1.1987346613539e-06 12 877796 SGTC_532 1548-0774 215 µM 4.55625955283887 3.96549283969585e-06 yes 10 2.6036292631286e-06 7 5932993 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 4.5205270261562 4.66993188809592e-06 yes 11 3.08429345083115e-06 9 115019 SGTC_2496 diffractaic acid 79.83 µM 4.44763774827786 6.49491127485706e-06 yes 12 4.34098917247702e-06 14 94870 An apoptosis inducer which activates caspases. SGTC_3154 9100113 49.47 µM 4.3781990529757 8.8524849068674e-06 yes 13 5.98320172812368e-06 22 25237525 SGTC_2347 9049783 174.81 µM 4.29436816997761 1.27894018286366e-05 yes 14 8.75957713919571e-06 17 6467988 YPL169C MEX67 SGTC_571 k831-0106 44.2 µM 4.15419876505011 2.33194511485392e-05 yes 15 1.6321466795731e-05 10 4783639 SGTC_2318 6029776 164 µM 4.13815997956044 2.49497334995383e-05 yes 16 1.75051115655655e-05 25 818325 SGTC_2936 9038235 15.59 µM 4.09606663756357 2.97576095059068e-05 yes 17 2.1011450770438e-05 16 4749415 SGTC_3044 9093193 49.47 µM 4.05527772442158 3.52437608753508e-05 yes 18 2.50373852826808e-05 21 25236277 SGTC_2268 7933382 153.85 µM 4.00410418906448 4.34845003285321e-05 yes 19 3.11264628071763e-05 36 935025 YOR257W CDC31 SGTC_2407 paclitaxel 400 µM 3.97488288082024 4.8974779484879e-05 yes 20 3.52069492294038e-05 34 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_801 0866-0028 10.1 µM 3.97012573835562 4.99282952647055e-05 yes 21 3.59173561138528e-05 28 6849771 SGTC_1096 rimcazole 32.2 µM 3.78065387718608 0.00010581542642124 yes 22 7.82085036857014e-05 15 18528119 A dopamine reuptake inhibitor. SGTC_560 2332-1943 155 µM 3.58713400644393 0.000220286626880515 yes 23 0.000167166262184215 17 21177716 SGTC_1682 st012968 530 nM 3.55217809117362 0.000250568195194541 yes 24 0.000191028090289864 30 24207270 SGTC_1616 st002734 56.1 µM 3.54735371223875 0.000255039909559015 yes 25 0.000194560891237301 43 4026101 SGTC_488 nitrendipine 139 µM 3.51191513508237 0.000290240139145997 yes 26 0.000222445019014545 61 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2969 9091408 28.7 µM 3.3926963155007 0.000444641254238184 yes 27 0.000346041598070445 51 4286311 SGTC_147 4466-0538 29.23 µM 3.39150622968454 0.000446509561503258 yes 28 0.000347547914564872 45 6742687 YHR072W ERG7 SGTC_582 0987-0078 156 µM 3.36224231840936 0.000494804305397489 yes 29 0.000386561231335055 110 1625765 SGTC_2414 st077232 92.9 µM 3.34551414583885 0.000524539731743768 yes 30 0.000410650848280699 41 729801 SGTC_3151 9099821 49.47 µM 3.29809563973941 0.000618051037619489 yes 31 0.000486714861480601 45 17174189 SGTC_1454 4239-0054 42.6 µM 3.29518920820954 0.00062425566672317 yes 32 0.00049177716000255 60 1340767 SGTC_2122 5258151 111.688 µM 3.29049178937918 0.000634405396796675 yes 33 0.000500062102355534 45 2173356 SGTC_3332 9141069 11.198 µM 3.24505639671162 0.00074074551946468 yes 34 0.000587136824032981 38 17332883 SGTC_1248 0469-0687 58.6 µM 3.2437021922763 0.00074415353277725 yes 35 0.000589935182881179 61 4017482 SGTC_583 1488-1091 88.9 µM 3.22276361831685 0.000798720006255751 yes 36 0.000634801396303596 47 4303273 SGTC_2948 9070189 9.45 µM 3.16538577427879 0.000967673995727591 yes 37 0.000774387294356951 66 6473636 YDL196W YDL196W SGTC_3338 9144300 39.5675 µM 3.10230225578951 0.00119086900492271 no 38 0.000960108941857163 53 4901274 SGTC_720 r052-1644 49.9 µM 3.09603018354916 0.00121546000628681 no 39 0.00098065197826099 57 1422863 YOR257W CDC31 SGTC_1629 st005085 44.9 µM 3.0580045548884 0.00137476535900436 no 40 0.00111408094624992 76 24207091 SGTC_500 h-89 112 µM 3.01013981026103 0.00160234172941943 no 41 0.00130563729992783 71 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1158 4092-0494 91.8 µM 2.9970696049093 0.00167019116295613 no 42 0.0013629423332568 48 1148199 SGTC_479 n-linoleoylglycine 10 µM 2.96885973028227 0.00182563322788261 no 43 0.00149453503819873 36 6433346 An anti-infammatory. SGTC_1436 4092-1007 8.32 µM 2.94049899286532 0.00199505910490757 no 44 0.00163842033409093 48 2881121 SGTC_2202 7226349 200 µM 2.92782193205564 0.00207530947313932 no 45 0.00170672738618357 37 844334 SGTC_600 1495-0418 41.6 µM 2.91241254786678 0.00217679454593319 no 46 0.00179324305619485 49 5377768 SGTC_651 3253-0966 34.4 µM 2.90358699489622 0.00223692513611604 no 47 0.00184457231159027 84 781462 SGTC_194 1486-1323 56.904 µM 2.89337246833563 0.00230839539323593 no 48 0.00190564516217079 52 5178754 SGTC_2605 digitonin 300 nM 2.88270912121492 0.00238520635908023 no 49 0.00197135666994414 94 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2644 guaiazulene 100 µM 2.87463381957573 0.00244490601104832 no 50 0.00202248158998461 26 3515 A coloring agent. SGTC_3244 9134489 49.47 µM 2.85955707379286 0.00255999598160521 no 51 0.00212116536246412 75 16584271 SGTC_833 3852-0053 558 µM 2.82127647555287 0.00287453042964474 no 52 0.00239164794377072 75 3123681 SGTC_1443 4112-3303 14 µM 2.81748599420437 0.00290749805164526 no 53 0.00242006128077886 49 704433 SGTC_2815 7968870 71.43 µM 2.79624280567342 0.00309864880479915 no 54 0.00258502713366127 91 2977326 YHR190W ERG9 SGTC_62 0180-0423 3.232 µM 2.76502097888325 0.00340015358354056 no 55 0.00284595675260959 79 30102 YGL099W LSG1 SGTC_558 k064-0027 21.3 µM 2.7235583122812 0.00384123331744975 no 56 0.0032291406735111 95 5088526 SGTC_1846 st056244 14.8 µM 2.69987453952471 0.00411558559154658 no 57 0.00346828143993617 111 5393182 SGTC_2240 6690706 185.951 µM 2.69810944080308 0.0041367180241092 no 58 0.00348672555405947 65 805876 SGTC_1441 4106-0040 13 µM 2.69679546636993 0.00415251240874928 no 59 0.00350051286662834 64 2904180 SGTC_2802 7925815 54.55 µM 2.69315669808422 0.00419653350047713 no 60 0.00353894974605413 116 1262923 SGTC_2964 9083345 53.42 µM 2.67438222901285 0.00443036345369721 no 61 0.00374335335007614 89 17741579 SGTC_92 0063-0024 660.874 µM 2.66735021655472 0.00452089769596948 no 62 0.00382259793846718 70 3594437 SGTC_3348 9149464 3.537 µM 2.65895612972701 0.00463112834256186 no 63 0.00391915843597761 86 1951442 SGTC_2647 atorvastatin 60.16 µM 2.65481957767033 0.00468632644783071 no 64 0.00396754185323458 79 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_309 k408-0051 1.48 µM 2.6525047557671 0.0047174708588151 no 65 0.00399485011813906 167 3640463 SGTC_475 α-linolenic acid 10 µM 2.64306497597816 0.00484639696159063 no 66 0.00410796334983142 91 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2869 9037858 32.47 µM 2.6306257030624 0.00502108188578344 no 67 0.00426139222286136 73 27187042 SGTC_2424 5537928 59.2 µM 2.57946320976001 0.00579995195030214 no 68 0.00494769992003415 134 5382802 SGTC_1424 4048-1941 275 µM 2.55141944862612 0.00627086041330369 no 69 0.00536425604704688 113 X1424 SGTC_2400 5203494 178.7 µM 2.54005186740393 0.00647118822762876 no 70 0.00554180152444257 106 6777674 SGTC_3049 9092223 49.47 µM 2.525450326504 0.00673680171129141 no 71 0.00577750577706011 114 8623917 SGTC_1705 st027868 56.3335 µM 2.51969575713014 0.00684410004408692 no 72 0.00587281541930962 87 292948 SGTC_3277 9138724 49.47 µM 2.51216072564413 0.0069868772002648 no 73 0.00599972119754018 81 15943418 SGTC_506 n9-isopropylolomoucine 153 µM 2.50288730051595 0.00716619874336601 no 74 0.00615923814190173 94 6610355 SGTC_1027 k015-0025 8.67 µM 2.49872138032844 0.00724806876291478 no 75 0.00623211320825053 123 3598955 SGTC_2736 butenafine 14.65 µM 2.48514668909807 0.00752059367514655 no 76 0.00647490305691877 139 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_423 5-fluorouracil 457 µM 2.47972726477779 0.00763188997298984 no 77 0.00657414552089771 124 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_380 3970-0968 6 µM 2.47688264551217 0.00769088699071009 no 78 0.00662677360980926 116 2891601 SGTC_3028 9087778 49.47 µM 2.46672628760639 0.00790481666179233 no 79 0.00681772711136556 94 17217395 SGTC_3233 9132340 49.47 µM 2.46342890671733 0.00797538805751624 no 80 0.00688075918795192 102 17682950 SGTC_865 0488-0499 301 µM 2.45583912855477 0.00813993514314859 no 81 0.00702780313171276 104 9634651 SGTC_669 0108-0021 26.2 µM 2.45077982412243 0.00825127152967492 no 82 0.00712735585786544 238 17201 SGTC_458 nppb 133 µM 2.44420621095012 0.00839792885828946 no 83 0.0072585631331354 93 4549 A chloride channel blocker. SGTC_2907 7721985 69.9 µM 2.43883056526319 0.00851955530239675 no 84 0.00736743758428032 136 3267881 SGTC_638 3970-0837 4.09 µM 2.43306221924305 0.00865178331205996 no 85 0.00748586397129377 151 4118451 YLR208W SEC13 SGTC_1028 k015-0029 4.8 µM 2.42985070253149 0.00872617826342299 no 86 0.00755252176118828 159 4588309 SGTC_2829 7992743 58.44 µM 2.41342150967384 0.0091156008376282 no 87 0.0079017656643217 168 16462845 SGTC_1146 3579-1023 7 µM 2.40725281740249 0.00926569995004286 no 88 0.00803651935744956 133 X1146 SGTC_2725 haloperidol 53.21 µM 2.39757614326699 0.00950551492403204 no 89 0.00825197519447382 164 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1031 k035-0009 16 µM 2.39269329642379 0.00962857277067329 no 90 0.00836260778406708 161 5180959 SGTC_2377 9073351 62.6 µM 2.39064401049861 0.00968063240281486 no 91 0.00840942586631044 139 7337946 YHR072W ERG7 SGTC_2478 5763493 32.33 µM 2.38524222090165 0.00981903865369001 no 92 0.008533939672944 121 1365576 YLR208W SEC13 SGTC_1666 st014829 29 µM 2.37046100183205 0.0102066384175783 no 93 0.00888295902288061 136 3858230 SGTC_425 3825-7017 13.1 µM 2.36814822241923 0.0102684772854976 no 94 0.00893868606983696 161 3397440 SGTC_1948 st076329 66.6 µM 2.34822031597237 0.0108149814934868 no 95 0.00943167995606002 147 24208413 SGTC_905 2-aminofluorene 215 µM 2.34447478766953 0.0109204786877888 no 96 0.00952694935324261 159 1539 An established DNA mutagen. YPR165W RHO1 SGTC_409 arachidonic acid 100 µM 2.33098965160261 0.0113077539704488 no 97 0.00987695267950255 132 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_69 0096-0274 206.684 µM 2.31804462750145 0.0116906911242151 no 98 0.0102234478912815 212 6741392 SGTC_165 k038-0023 64.381 µM 2.31615107619573 0.011747639112434 no 99 0.0102750106785149 237 46368543 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.30253564815442 0.0121642535905435 no 100 0.0106524917391346 130 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_842 0271-0008 11.1 µM 2.29195595438522 0.0124967625439436 no 101 0.0109540924641327 142 1221709 SGTC_1385 3091-4834 14.1 µM 2.28978681219512 0.0125659003156608 no 102 0.0110168390091191 134 4072814 SGTC_2911 7942208 15.64 µM 2.27493496090809 0.0130482331129789 no 103 0.0114549158563968 125 1243384 SGTC_1965 Pectolinarigenin 58.4 µM 2.26820748129313 0.0132719311133247 no 104 0.0116582818455395 118 5320438 An anti-inflammatory. SGTC_2295 7971645 200 µM 2.26571074938622 0.0133557897728266 no 105 0.0117345494788284 160 2978226 YKL099C UTP11 SGTC_1933 st074711 15.9 µM 2.25936259766014 0.0135710711944672 no 106 0.0119304194969633 200 17250958 SGTC_2063 5246145 200 µM 2.25803984613744 0.0136163040757234 no 107 0.0119715876714471 180 711240 SGTC_2345 9052315 157.45 µM 2.21747077178236 0.0150682044869266 no 108 0.0132954691050004 175 6469265 SGTC_293 4049-0273 38.5 µM 2.21375904932315 0.0152074518174247 no 109 0.0134226792389718 124 1380311 SGTC_1437 4092-1038 11.6 µM 2.20018501756392 0.0157261421941943 no 110 0.0138968854263887 155 3977136 SGTC_789 1309-1135 70.6 µM 2.19521305261244 0.0159198918583042 no 111 0.0140741592016809 183 3092424 SGTC_1262 0737-0114 49.6 µM 2.18249629145728 0.0164247788022947 no 112 0.0145364623319526 202 765919 SGTC_2670 beta-carotene 100 µM 2.1532872107901 0.0176365927555282 no 113 0.0156480566407778 91 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_177 1327-0068 8.361 µM 2.14244190094216 0.0181055686230558 no 114 0.0160789695889374 232 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_744 1594-0068 283 µM 2.14197514921036 0.0181259883792706 no 115 0.0160977409115009 226 668392 SGTC_373 0844-0104 25.9 µM 2.13978252608324 0.0182221755649227 no 116 0.0161861730062789 222 5375804 SGTC_398 bronopol 33.3 µM 2.13707615674866 0.0183414995119335 no 117 0.0162958989481833 187 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1631 benzylvanillin 81.9 µM 2.13378869277149 0.0184873387194208 no 118 0.0164300409519557 207 75506 SGTC_1486 3970-0793 4.53 µM 2.12741401425442 0.0187729488195837 no 119 0.0166928493746745 129 2844330 SGTC_1154 4088-0362 150 µM 2.12400498860233 0.0189272212119257 no 120 0.0168348632157632 236 6618304 SGTC_1763 st044482 94.5 µM 2.10166211292535 0.0199652556368405 no 121 0.0177914423301242 195 88505 SGTC_2050 5263056 171 µM 2.10088519206545 0.0200022031152506 no 122 0.017825522802516 241 763468 YGL055W OLE1 SGTC_967 1306-0166 352 µM 2.09379110462465 0.0203422624973369 no 123 0.0181392964634259 213 4437607 SGTC_795 0685-0265 78 µM 2.08777605652653 0.020634424517049 no 124 0.0184090201855102 208 302754 SGTC_2148 5546263 113.568 µM 2.07158003504385 0.0214388169646605 no 125 0.0191523117063222 194 792097 SGTC_331 k048-0133 24.5 µM 2.05673633264872 0.0221991713930373 no 126 0.0198557976326925 150 6813582 SGTC_940 3232-1287 54.8 µM 2.056184846649 0.0222278536624076 no 127 0.0198823511676404 211 1585493 YIL048W NEO1 SGTC_1721 st082152 9.2685 µM 2.05402180896397 0.0223406532429549 no 128 0.0199867904737186 196 5296051 SGTC_2099 5377090 177.372 µM 2.04531394093404 0.0227996539194231 no 129 0.0204119585859877 225 2243829 SGTC_2628 lathosterol 100 µM 2.04173996652212 0.0229903286387833 no 130 0.0205886660267484 214 6710616 SGTC_876 0720-0963 56.8 µM 2.04062063257515 0.0230503215997813 no 131 0.0206442748689849 194 765861 SGTC_2685 mycophenolic acid 18.85 µM 2.03444472867497 0.0233837069842262 no 132 0.0209533879890962 143 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_674 0498-0004 451 µM 2.02399552623267 0.0239570103349659 no 133 0.0214853060309745 232 4231473 SGTC_1714 st033236 13.627 µM 2.02233325942304 0.0240492920268034 no 134 0.021570967424531 220 2916566 SGTC_154 3389-1638 511.116 µM 2.02042528891808 0.0241555820610656 no 135 0.0216696462355892 210 5238686 SGTC_1604 st002052 72.4 µM 2.01895265878548 0.0242378895406469 no 136 0.0217460701189209 204 6254834 YHR062C RPP1 SGTC_1961 st076550 68.7 µM 2.01667258199581 0.0243657909934225 no 137 0.021864846508671 179 1579337 SGTC_2292 7671323 168.05 µM 2.00556372369404 0.0249970786060984 no 138 0.0224514077750674 269 937504 SGTC_2329 6138490 200 µM 1.99407183126317 0.0256645055285332 no 139 0.0230721025520723 215 720019 SGTC_2247 cerulenin 830 nM 1.99209130206372 0.0257810246464633 no 140 0.0231805205651311 215 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2149 5554786 194.827 µM 1.98944866594102 0.0259371862325924 no 141 0.0233258512881563 277 745063 YPR165W RHO1 SGTC_2235 salicylic acid 500 µM 1.98788312408117 0.0260300716856646 no 142 0.0234123087936211 149 338 A COX inhibitor and kinase inhibitor. SGTC_2755 lomerizine 42.69 µM 1.98417362807262 0.0262512716202552 no 143 0.0236182436935823 240 3949 A calcium channel blocker. SGTC_641 4092-0595 30 µM 1.98208044761804 0.0263767815710425 no 144 0.0237351187552166 229 786260 SGTC_1113 artemisinin 1.17947 µM 1.98204326967205 0.0263790153365784 no 145 0.0237371990146154 201 2240 An anti-malaria and mitochondrial poison. SGTC_2616 abietic acid 100 µM 1.97829182621304 0.0266052278976783 no 146 0.0239478973431814 248 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_245 methotrexate 289.6 µM 1.97175857644115 0.0270030518545816 no 147 0.0243185865963717 270 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_117 lucigenin 22.078 µM 1.96845729239833 0.0272059551023813 no 148 0.0245077227063032 327 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1195 1502-0147 41.1 µM 1.96009424096807 0.0277256628922936 no 149 0.0249923881256828 255 817940 SGTC_1302 1159-0335 255 µM 1.95953946431837 0.0277604291945863 no 150 0.0250248214380812 202 649284 SGTC_2864 9034755 47.6 µM 1.95269708759891 0.0281922166508325 no 151 0.0254277495039791 231 4930451 SGTC_1156 4092-0367 4.88 µM 1.94922043544371 0.0284137436945476 no 152 0.0256345527669458 247 1357585 SGTC_2028 5153890 36.43 µM 1.94878920955859 0.0284413214541739 no 153 0.0256603014540001 238 2830968 YPR165W RHO1 SGTC_1982 st072467 71.9 µM 1.94745272964683 0.0285269335257838 no 154 0.0257402408281063 283 3163533 SGTC_1745 st081495 74 µM 1.94726829842505 0.0285387646147393 no 155 0.0257512886312449 336 13842402 YBL026W LSM2 SGTC_2583 asiatic acid 100 µM 1.93728898859048 0.0291850398895748 no 156 0.0263550137653413 239 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1122 capsaicin 818.572 nM 1.93626593916281 0.0292519758215675 no 157 0.0264175690797366 237 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_357 1325-0123 420 µM 1.92667716535806 0.029885568277749 no 158 0.0270099376623369 199 1098503 SGTC_1331 1472-0049 76.2 µM 1.91637205399928 0.0305791415105368 no 159 0.027658877664704 254 24051409 SGTC_1867 st057372 64 µM 1.89406079860642 0.0321265103101753 no 160 0.0291084701509011 228 688837 SGTC_1802 st050112 57.9 µM 1.89145908787877 0.0323110851091871 no 161 0.0292815436879124 233 4662563 SGTC_2029 5175081 200 µM 1.89015255654975 0.0324041047462158 no 162 0.0293687798881684 281 1380876 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.89010349726065 0.0324076018646316 no 163 0.0293720597425851 217 229346 A bile salt which induces apoptosis. SGTC_3318 9139014 38.6185 µM 1.88704298711753 0.0326263822115051 no 164 0.029577272014767 229 16643984 SGTC_364 0083-0097 67.7 µM 1.88289874233468 0.0329245732544447 no 165 0.0298570458554154 252 5207356 SGTC_523 1934-0222 13.7 µM 1.87813247833233 0.0332702939852968 no 166 0.0301815221353488 272 1361595 SGTC_2307 7538926 6.34 µM 1.87654897509679 0.0333858128803103 no 167 0.0302899681553548 310 96582 SGTC_2770 toltrazuril 17.5 µM 1.86961219703924 0.033895759831329 no 168 0.0307688451383577 279 68591 Kills coccidiodes. SGTC_31 0508-1974 57.237 µM 1.86470525977313 0.0342603414040837 no 169 0.0311113645574111 237 6810525 SGTC_466 geldanamycin 89.2 µM 1.86209791074716 0.0344553729911835 no 170 0.0312946452319297 161 5288382 HSP90 inhibitor. SGTC_1065 prochlorperazine maleate 2.48 µM 1.85813247050307 0.0347537386470724 no 171 0.0315751023896396 275 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1300 1094-0077 113 µM 1.85548076839766 0.0349544378841887 no 172 0.0317638015097824 240 5532636 SGTC_3309 9129340 25.759 µM 1.84829161279758 0.0355033529463226 no 173 0.0322800842027935 262 17158987 SGTC_1674 st016616 23.6 µM 1.84135978748984 0.0360392929514802 no 174 0.0327844257927185 286 625830 SGTC_1979 st071809 45.3 µM 1.83993677314768 0.0361501301892332 no 175 0.0328887602108474 248 4976333 SGTC_93 0109-0045 59.227 µM 1.83375491037347 0.0366348741002166 no 176 0.0333451918087658 376 88733 SGTC_2998 9066762 71.4286 µM 1.82187166237007 0.0375816183366514 no 177 0.0342372304859069 329 4945196 SGTC_16 erodoxin 22.806 µM 1.8172633754043 0.0379540975551562 no 178 0.03458839752658 375 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2977 9011197 71.43 µM 1.81492088677814 0.0381445880775964 no 179 0.0347680341113676 214 2704722 SGTC_2155 5570423 76 µM 1.80250388899525 0.0391673962512552 no 180 0.0357330816951245 272 797402 SGTC_624 k048-0052 28 µM 1.79661745257812 0.0396600127677696 no 181 0.036198185894695 262 6835531 SGTC_1053 3366-3204 134 µM 1.79434429827856 0.0398515889897402 no 182 0.036379115830942 322 3632071 YPR165W RHO1 SGTC_1130 3454-2858 15.9 µM 1.79397646607956 0.0398826596358334 no 183 0.0364084626040203 345 715628 YIL048W NEO1 SGTC_55 0767-0285 6.563 µM 1.78267753936675 0.0408467067728139 no 184 0.0373194047999545 361 3116166 SGTC_1665 st014639 11.4 µM 1.77755345115033 0.0412900924122467 no 185 0.0377386123445523 331 981133 YIL048W NEO1 SGTC_3020 9089140 49.47 µM 1.77673456138732 0.041361310898749 no 186 0.0378059615154806 299 17217859 SGTC_1193 1488-0126 41.5 µM 1.77586650086981 0.041436914418482 no 187 0.0378774617821172 323 1384710 SGTC_1531 st059297 52.4 µM 1.76932096850542 0.0420106084254438 no 188 0.0384201630573032 291 7566702 SGTC_2639 lactacystin 53 µM 1.76906616400655 0.0420330705545236 no 189 0.0384414168448107 306 3870 A proteasome inhibitor. SGTC_2946 9065502 71.43 µM 1.76787648039369 0.0421380750480005 no 190 0.038540777763355 170 16489101 SGTC_484 loperamide 105 µM 1.75952905591848 0.0428808234864012 no 191 0.0392438447623076 163 3955 An opioid-receptor agonist. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.75758649447433 0.0430551801986442 no 192 0.0394089464849288 340 6708561 SGTC_721 1187-1332 279 µM 1.7564877062431 0.0431540564549691 no 193 0.0395025843768117 202 25730 SGTC_326 k292-0812 17.5 µM 1.75106359046796 0.0436448448774095 no 194 0.0399674784933832 244 3579357 SGTC_68 0986-0284 82.829 µM 1.74975224406908 0.043764172591416 no 195 0.0400805372156773 339 423278 YIL048W NEO1 SGTC_1359 1582-0056 520 nM 1.74916793082539 0.0438174276569106 no 196 0.0401309978448829 338 3661189 SGTC_2140 5586273 200 µM 1.74853491835429 0.0438751802144098 no 197 0.04018572231562 240 854421 SGTC_1423 4048-0112 5.59 µM 1.74786578948974 0.0439362945686596 no 198 0.0402436349708211 301 X1423 SGTC_919 tnp00227 403.569 nM 1.74076274420547 0.0445892871145376 no 199 0.0408625874592813 354 1269246 A methoxyflavone. YNL221C POP1 SGTC_733 4069-0007 56.1 µM 1.74047222602927 0.0446161603602909 no 200 0.0408880664189918 400 5717425 YNL287W SEC21 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.73970354488535 0.0446873271245159 no 201 0.0409555432866905 310 66535 A nucleotide analog. SGTC_3273 9137859 49.47 µM 1.73622688935165 0.0450103487458435 no 202 0.0412618622716677 237 2377234 SGTC_3124 9127567 49.47 µM 1.72848993751396 0.0457359469927242 no 203 0.0419502117633836 279 17592030 SGTC_1698 5-fluorocytosine 1.055 µM 1.72724928377437 0.0458531697215145 no 204 0.042061451607436 288 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_545 4218-0007 221 µM 1.72628675286894 0.0459442803306168 no 205 0.0421479186926646 293 2840508 SGTC_2267 7931562 200 µM 1.72501415789861 0.0460649640031696 no 206 0.0422624605396056 294 934880 SGTC_1709 st033179 39.1045 µM 1.72255636488814 0.0462987639999127 no 207 0.0424843908078074 331 573381 SGTC_648 0375-0473 33.3 µM 1.72211932601423 0.0463404373584966 no 208 0.0425239524415194 345 1713139 SGTC_2234 tolnaftate 200 µM 1.7220319242957 0.0463487750651964 no 209 0.0425318677936657 209 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_977 1348-1378 135 µM 1.72202639583551 0.0463493024944033 no 210 0.0425323685070553 297 X977 SGTC_2634 4'-methoxyflavone 100 µM 1.72158025851879 0.0463918810195917 no 211 0.0425727909408989 310 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2776 terbinafine 19.92 µM 1.72098833108506 0.0464484219481644 no 212 0.0426264706853951 325 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2654 protoveratrine a 100 µM 1.71482270088998 0.0470406576809573 no 213 0.0431888690925546 282 5702278 A heart drug and vasodilator. SGTC_2201 6605497 169.863 µM 1.71158919740635 0.047353661523837 no 214 0.0434862002411019 271 670741 SGTC_847 0342-0274 5.54 µM 1.71097401022249 0.0474134003226907 no 215 0.0435429553523829 313 18097 SGTC_1664 st014217 9.02 µM 1.70820145116881 0.0476833841065573 no 216 0.043799484680302 329 3982782 SGTC_1944 st076371 56.9 µM 1.7036748906925 0.048126812004999 no 217 0.0442209208076576 326 24208455 SGTC_3351 9150312 21.596 µM 1.69786108273505 0.0487011742184359 no 218 0.0447669919744978 335 4904905 SGTC_2557 derrustone 83.84 µM 1.69142908723067 0.0493429790847543 no 219 0.0453774404075669 393 629853 An antioxidant. SGTC_1074 carmofur 3.8 µM 1.68900565823615 0.0495865409242708 no 220 0.0456091728159329 387 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1495 4469-0029 237 µM 1.68405273883351 0.0500873078750261 no 221 0.046085738444119 480 793680 SGTC_1770 st043884 66.3 µM 1.68293646089515 0.0502007245266366 no 222 0.0461936961662561 326 670149 SGTC_3095 9117207 49.47 µM 1.6824804827005 0.0502471119107689 no 223 0.046237853215132 243 17015229 SGTC_1049 3226-0134 66 µM 1.67764410224688 0.0507412302454822 no 224 0.0467082988804958 378 5702385 SGTC_2412 st077135 33.4 µM 1.67747738836226 0.0507583316419511 no 225 0.0467245837352407 344 13258915 SGTC_1817 st052116 64.4 µM 1.67461122129898 0.0510530594461781 no 226 0.0470052680852282 317 4361398 SGTC_2555 cholic acid 100 µM 1.67267242425882 0.0512531969621373 no 227 0.0471959003488235 316 6708657 Influences liver metabolism. SGTC_2467 5474540 200 µM 1.66408197197276 0.0521474900989602 no 228 0.0480480246241797 358 5413519 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.66129441983095 0.0524403318958762 no 229 0.0483271650967068 362 4174840 SGTC_2192 5915882 198.485 µM 1.65857289724725 0.0527274950627312 no 230 0.0486009434663731 276 2876149 SGTC_490 phenamil 164 µM 1.65719679951988 0.0528731690712002 no 231 0.0487398467039641 227 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1578 josamycin 24.2 µM 1.65643276467507 0.0529541876950605 no 232 0.0488171052312045 315 5282165 A P450 substrate. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.65620106285194 0.0529787769163185 no 233 0.0488405540450468 457 6708739 YPR165W RHO1 SGTC_800 3448-7362 155 µM 1.65457322332556 0.053151785822689 no 234 0.0490055494018429 637 15991913 SGTC_2785 7756463 72.73 µM 1.65219018005119 0.0534058662781112 no 235 0.0492478938340458 339 2201551 SGTC_615 k087-0205 167 µM 1.64842279576195 0.053809507946459 no 236 0.0496329706942245 320 9642773 SGTC_2729 fluphenazine 10.66 µM 1.6471040325943 0.0539513711604519 no 237 0.0497683322025214 371 3372 An atypical antipsychotic. SGTC_101 0490-5701 117.494 µM 1.64594335790362 0.0540764731671265 no 238 0.0498877105891718 284 4661669 SGTC_2506 ethyl hematommate 54.16 µM 1.63682784836626 0.0550669771214152 no 239 0.0508332225796498 298 3940691 An allergen. SGTC_3334 9142812 21.919 µM 1.6348969815379 0.0552786163103452 no 240 0.051035322680165 344 45283678 SGTC_2926 9010726 65.15 µM 1.63297991814841 0.0554893775395854 no 241 0.0512366101537421 372 2994293 SGTC_2923 7992654 58.14 µM 1.63191748985457 0.0556064534283064 no 242 0.0513484345298216 358 2985126 SGTC_610 4215-0184 155 µM 1.62879082984618 0.0559521318916387 no 243 0.0516786533158421 377 5605015 SGTC_2661 dactinomycin 12.96 µM 1.62273438013902 0.0566265431149141 no 244 0.0523230992975605 379 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_286 k060-0067 22.9 µM 1.61934301331318 0.0570069738607884 no 245 0.052686740375406 353 5985051 SGTC_291 SEC14.278 35.5 µM 1.6151099723134 0.0574846404835846 no 246 0.0531434408843473 359 1068044 SGTC_3269 9137823 49.47 µM 1.61508442944148 0.057487532330369 no 247 0.0531462061875178 328 17682936 SGTC_90 0870-0863 4.608 µM 1.6124063239922 0.0577913706709419 no 248 0.0534367748120333 407 1738164 SGTC_521 r062-0005 13.8 µM 1.6109927561516 0.0579522520883554 no 249 0.0535906506556262 352 2832033 SGTC_1547 harmine 94.2 µM 1.60958282360314 0.05811307021521 no 250 0.0537444802346433 448 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_221 trifluoperazine 10.304 µM 1.60133570824788 0.0590607782157083 no 251 0.0546512920736332 567 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2426 5582046 32.21 µM 1.59190783861506 0.0601589759294534 no 252 0.0557027070125409 394 2251934 SGTC_3286 9117135 37.221 µM 1.59008826526625 0.0603727563726403 no 253 0.0559074553506994 382 3438150 SGTC_1324 1418-0026 34.4 µM 1.58853108376727 0.0605561802793562 no 254 0.0560831489798851 392 1372513 SGTC_572 0960-0087 17.7 µM 1.58808278054947 0.0606090676674802 no 255 0.0561338107635802 442 6796365 SGTC_668 1682-0499 62.6 µM 1.5869495936132 0.0607429135039693 no 256 0.0562620306901312 450 682214 SGTC_2241 6772625 37.8075 µM 1.58428860883355 0.0610581231834083 no 257 0.0565640284191758 378 2285411 SGTC_1404 3909-7820 48.3 µM 1.58279430680094 0.0612356920084838 no 258 0.0567341773882038 345 23741373 SGTC_140 0062-0056 502.533 µM 1.5827395365835 0.0612422080447836 no 259 0.0567404214598168 427 3758964 SGTC_3219 9131112 49.47 µM 1.58204406400522 0.0613249958419965 no 260 0.0568197558078717 365 17612988 YMR079W SEC14 SGTC_3059 1327-0034 3 µM 1.58001216625021 0.0615673702042344 no 261 0.0570520401570935 405 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1316 1272-0050 65.9 µM 1.57817524474214 0.0617871301307564 no 262 0.0572626778510621 355 7340392 SGTC_616 4092-0450 108 µM 1.57667264973687 0.0619673478421497 no 263 0.0574354333593463 409 787165 SGTC_2167 5876490 200 µM 1.56815887756365 0.0629962271793847 no 264 0.0584220293589123 392 686534 SGTC_329 k048-0121 21.3 µM 1.56802036581976 0.0630130755016775 no 265 0.0584381897629092 358 6832902 SGTC_3231 9132313 49.47 µM 1.56533275667491 0.063340686749088 no 266 0.0587524531555696 372 4905967 SGTC_3354 9151612 71.43 µM 1.563929238522 0.06351229749749 no 267 0.0589170935777052 403 27261949 SGTC_1090 efavirenz 20.7 µM 1.56389563294181 0.0635164109449048 no 268 0.0589210401307216 369 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2753 fluvastatin 17.09 µM 1.56289451944575 0.0636390460533734 no 269 0.0590387034830319 426 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1384 3089-0840 101 µM 1.56208318866182 0.0637385681123757 no 270 0.0591341963582296 345 1069836 SGTC_1984 st072354 53.1 µM 1.56136637844831 0.0638265964866151 no 271 0.0592186650081053 353 5762938 SGTC_986 1493-0483 84 µM 1.56017047974998 0.063973670101344 no 272 0.0593597998470891 354 40079 SGTC_868 0527-0199 213 µM 1.54380234798213 0.0660132369652003 no 273 0.0613181111792727 406 2849450 SGTC_1633 st005664 67.9 µM 1.5415363069618 0.0662995258953707 no 274 0.0615931568004259 426 2063822 SGTC_462 ag-879 158 µM 1.54134446469738 0.0663238070969296 no 275 0.0616164862322586 433 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2384 9036245 200 µM 1.53836696665443 0.0667015482268138 no 276 0.0619794571826876 412 6462766 SGTC_2137 5261020 140 µM 1.53052075093301 0.0677049351696525 no 277 0.0629439405470264 404 763655 SGTC_1311 1190-0148 100 µM 1.53046252077382 0.0677124250865621 no 278 0.062951141854212 500 1961333 SGTC_305 1682-2595 20.8 µM 1.5294658544521 0.067840721621926 no 279 0.0630744988240836 393 226033 SGTC_3072 9116419 49.47 µM 1.52897438898322 0.0679040549156512 no 280 0.0631353965644748 351 17170162 SGTC_2433 5607874 27.82 µM 1.52693297189148 0.0681676134162429 no 281 0.0633888398246546 411 2252428 SGTC_1496 4469-0713 57.4 µM 1.52517448005894 0.0683952770881978 no 282 0.0636077920283583 408 746691 SGTC_13 0199-0087 65 µM 1.52395493076079 0.0685535106014126 no 283 0.0637599850234646 419 4589825 SGTC_363 0455-0021 3.06 µM 1.52335598112892 0.0686313261616148 no 284 0.0638348342681588 449 4597466 SGTC_1675 st018485 24.5 µM 1.5207019252632 0.068976961190312 no 285 0.0641673276814766 402 3323024 SGTC_3227 9130768 49.47 µM 1.52062564473398 0.0689869149251479 no 286 0.0641769037776573 352 17720899 SGTC_1279 0874-0590 65.2 µM 1.52028588528299 0.0690312630875555 no 287 0.0642195699537153 413 3523074 SGTC_680 0417-1641 114 µM 1.50674163481293 0.0708171249653341 no 288 0.0659384475529666 381 2835990 SGTC_956 1185-0240 191 µM 1.50368951383147 0.0712244172556479 no 289 0.0663306652468341 400 1416193 SGTC_1363 1636-0063 10.4 µM 1.50268627428107 0.0713586872167817 no 290 0.066459981915295 431 6072185 SGTC_3160 9100216 49.47 µM 1.50069469793014 0.0716258081733321 no 291 0.0667172725335849 406 17191039 SGTC_2743 auranofin 4.32 µM 1.49961652943113 0.07177073766417 no 292 0.0668568817406085 386 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3036 9090181 49.47 µM 1.49912955968757 0.0718362707706968 no 293 0.0669200122214277 369 25236586 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.49443032979974 0.072471021636434 no 294 0.0675315895639823 425 4330530 SGTC_2417 cerulenin 830 nM 1.49007003912189 0.0730638248907956 no 295 0.0681029105137938 376 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_855 0428-0020 25 µM 1.48737286413658 0.0734323726520863 no 296 0.06845817987215 379 6812414 SGTC_3291 9121177 71.43 µM 1.48608270260147 0.0736091650117554 no 297 0.0686286234824013 362 17015612 SGTC_1778 st046819 58.9 µM 1.47560535242616 0.0750569615303921 no 298 0.0700249337119947 502 671715 SGTC_1613 st002381 52.1 µM 1.47333314454869 0.0753737896260111 no 299 0.0703306138357563 435 551167 SGTC_1265 0819-1001 68.8 µM 1.47244039629051 0.0754985496358073 no 300 0.0704509956433571 426 3106768 SGTC_1001 4048-4355 44.4 µM 1.46912687844034 0.0759629841960415 no 301 0.0708991893158089 414 21824233 SGTC_906 1165-0455 526 µM 1.46885160435878 0.0760016652533673 no 302 0.0709365218074234 412 3252859 SGTC_1847 st056231 15 µM 1.46515949175468 0.0765219252829097 no 303 0.0714387042960553 520 5393180 SGTC_3076 9116187 49.47 µM 1.4635768960075 0.0767457584700379 no 304 0.0716547945447665 406 27241210 SGTC_2194 5927483 104.545 µM 1.4634817733523 0.0767592279124013 no 305 0.0716677987082833 470 760979 SGTC_1668 st014914 51.6 µM 1.46288092389945 0.0768443502044774 no 306 0.0717499823324809 397 2839556 SGTC_580 1123-0028 41 µM 1.46277540520383 0.0768593064347284 no 307 0.0717644225398582 499 1677248 YPR107C YTH1 SGTC_1148 3909-7663 27.7 µM 1.46070502784465 0.077153209805356 no 308 0.0720482043328416 445 4084526 SGTC_3251 9135047 49.47 µM 1.46035877035763 0.0772024465231983 no 309 0.0720957488957977 361 17682963 SGTC_1178 0988-0033 191 µM 1.45601689317026 0.0778218758842955 no 310 0.0726939748547652 489 5392207 SGTC_289 k017-0060 526 µM 1.45199646386317 0.0783988029488377 no 311 0.0732512942383955 395 5512909 SGTC_2588 indole-3-carbinol 100 µM 1.45196757609705 0.0784029600128068 no 312 0.0732553105089997 496 3712 Induces cell cycle arrest. SGTC_972 1319-0219 195 µM 1.45097414449021 0.0785460204756078 no 313 0.0733935299953062 458 23903702 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.45070821763122 0.0785843491850226 no 314 0.0734305631175687 458 94937 An inhibitor of serotonin biosynthesis. SGTC_1670 st016595 4.04 µM 1.44921197140105 0.0788002712564616 no 315 0.0736391976701317 460 597879 SGTC_728 3030-5151 22.5 µM 1.44644516019333 0.0792007312261888 no 316 0.0740261915141558 412 3125388 SGTC_2775 cyproheptadine 69.59 µM 1.44138986961898 0.0799363957342559 no 317 0.0747372853081104 447 2913 A selective serotonin reuptake inhibitor. SGTC_1019 4262-0212 3.4 µM 1.44104121957133 0.0799873224128995 no 318 0.0747865190421422 553 4677213 SGTC_2212 7123476 200 µM 1.4407104597906 0.0800356585651852 no 319 0.0748332493176733 353 1085715 SGTC_3339 9145883 14.936 µM 1.43580495225751 0.0807551282159483 no 320 0.075528925128657 423 2030670 SGTC_1571 st070080 73.4 µM 1.43026480846693 0.0815735374497449 no 321 0.0763205155113255 448 4315245 SGTC_244 nsc-207895 1.295 µM 1.42782677303432 0.081935667876327 no 322 0.0766708623502961 357 42640 SGTC_2810 7959871 45.46 µM 1.42510994209966 0.0823406344970774 no 323 0.0770627115926415 541 2974535 SGTC_1703 st026983 48.3 µM 1.42475923690135 0.0823930197189518 no 324 0.0771134046091485 484 1104023 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.42377967713314 0.0825394705697848 no 325 0.0772551302411351 448 689007 SGTC_2717 st081029 62.2815 µM 1.42172426514005 0.082847405482524 no 326 0.07755315651546 423 5292846 SGTC_2994 9053520 71.4286 µM 1.42153635949174 0.0828755999382882 no 327 0.0775804455528834 466 4647384 SGTC_2082 5219693 150 µM 1.42025354613689 0.0830682735988601 no 328 0.0777669399472588 483 2834649 SGTC_2034 5197015 53.07 µM 1.41945745847292 0.0831880122075565 no 329 0.0778828455372467 484 780676 SGTC_1445 4239-0156 97.7 µM 1.41901151835641 0.0832551422211138 no 330 0.0779478290042486 530 4008346 SGTC_3224 9130643 49.47 µM 1.41417743609555 0.0839854610008146 no 331 0.0786549056492869 459 17644395 SGTC_710 3448-4187 58 µM 1.41264617254014 0.0842178000749664 no 332 0.0788798928751721 580 3946412 SGTC_2156 5649887 115 µM 1.41162807192887 0.0843725435792795 no 333 0.0790297511343042 538 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3116 9124943 49.47 µM 1.40532155274392 0.085335843425922 no 334 0.0799628410951375 448 41905195 YPL160W CDC60 SGTC_258 haloperidol 50.781 µM 1.40360841628488 0.0855989369181596 no 335 0.0802177437675168 490 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1549 4'-methoxyflavonol 74.6 µM 1.40225227136655 0.0858076360636336 no 336 0.0804199637447124 465 97141 SGTC_667 1498-1044 59 µM 1.40184681866125 0.0858701056754031 no 337 0.0804804970820588 474 6739982 SGTC_2602 kawain 100 µM 1.40087143660678 0.0860205258531711 no 338 0.0806262608156273 525 5369129 SGTC_1807 st050092 58.9 µM 1.39794327794768 0.0864732810473661 no 339 0.0810650505765374 468 5008496 SGTC_254 nsc-64875 3.808 µM 1.39671388373027 0.0866639015174106 no 340 0.0812498137323905 462 56993 SGTC_1417 3966-0327 90.4 µM 1.3950609214362 0.0869206919816966 no 341 0.0814987345990531 525 651118 SGTC_1863 st057641 20.1 µM 1.39381748828645 0.0871142357213751 no 342 0.0816863628622 514 3921635 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.3931528666976 0.0872178177708792 no 343 0.0817867846158455 402 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_816 0325-0417 81.3 µM 1.39265204952353 0.08729593144857 no 344 0.0818625176130758 449 68101 SGTC_3204 9114183 49.47 µM 1.3918623159975 0.087419214215065 no 345 0.0819820475716643 477 17027248 SGTC_2556 citropten 84.59 µM 1.38961104216116 0.0877713665588933 no 346 0.0823235104233569 540 2775 A potential DNA crosslinker. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.38611159249307 0.0883208623200997 no 347 0.0828564155549051 452 2374 Ca(2+)-ATPase inhibitor. SGTC_2009 4012297 12.05 µM 1.38289199463791 0.0888286754500425 no 348 0.083348992654437 481 45595307 SGTC_3268 9137683 49.47 µM 1.3803256461667 0.089235009019336 no 349 0.0837432010093621 425 1953228 SGTC_2665 lovastatin 100 µM 1.38009372850809 0.0892717968948692 no 350 0.0837788940049382 475 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2560 caryophyllene 100 µM 1.37874957603536 0.0894852349596217 no 351 0.0839859891755473 546 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1986 st071812 45 µM 1.37793645367126 0.0896145348241964 no 352 0.0841114543675896 436 11838594 SGTC_3065 9113888 49.47 µM 1.37676433655652 0.0898011651613021 no 353 0.0842925601611062 449 16648368 SGTC_1908 st060353 56.5 µM 1.37247296787752 0.0904869237323044 no 354 0.0849581242468358 556 4227716 SGTC_411 enrofloxacin 100 µM 1.37083341833009 0.0907499468684324 no 355 0.085213445390913 470 71188 A bacterial gyrase inhibitor. SGTC_1843 st055809 45.5 µM 1.37060421660142 0.0907867614879147 no 356 0.0852491839058649 473 16413835 SGTC_145 3737-0113 38.366 µM 1.36715620172556 0.091341923278853 no 357 0.0857881751533048 600 6849351 SGTC_3212 9128307 49.47 µM 1.36581207506357 0.0915590203284319 no 358 0.0859989776880569 449 27243542 SGTC_116 0155-0182 31.788 µM 1.36487581794109 0.0917104659772436 no 359 0.0861460419422302 643 771486 SGTC_2504 purpurogallin 52.29 µM 1.36394257287684 0.0918616090211304 no 360 0.0862928202151818 471 5281571 An antioxidant. SGTC_18 0111-0177 500 nM 1.36305817732747 0.0920050108633677 no 361 0.086432088095491 617 721752 SGTC_1231 0242-0792 125 µM 1.36110527215506 0.0923222550814665 no 362 0.0867402119000719 500 3707635 SGTC_2269 7935389 174.42 µM 1.3606787168007 0.092391655454384 no 363 0.0868076216799147 508 97605 SGTC_2726 cimetidine 79.27 µM 1.36035289892526 0.092444691882938 no 364 0.0868591379869911 422 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_675 1309-0189 238 µM 1.35792943621429 0.0928398887179552 no 365 0.0872430379425219 493 4246530 SGTC_3055 9094636 49.47 µM 1.35624394693028 0.0931154789838327 no 366 0.0875107817548316 473 25236176 SGTC_574 1315-0397 40 µM 1.35559789392495 0.0932212736771224 no 367 0.0876135711576379 588 6794277 SGTC_2116 5511452 16.8835 µM 1.35542079078493 0.0932502907847799 no 368 0.0876417646435181 513 870744 SGTC_311 1315-0136 58 µM 1.35447948495391 0.0934046291515207 no 369 0.0877917270520329 513 6759207 SGTC_1144 3486-0183 12.5 µM 1.35175366947379 0.0938526234973006 no 370 0.088227064907715 558 6744069 SGTC_1492 4158-0558 28.5 µM 1.34050229173042 0.095718603660856 no 371 0.0900410498798828 485 3967268 SGTC_2677 mitomycin C 100 µM 1.33938567342251 0.0959052671547634 no 372 0.0902225754632137 449 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_764 1951-2361 146 µM 1.33773350229485 0.0961819491737093 no 373 0.0904916628564101 533 5438930 SGTC_923 1900-2434 73.3 µM 1.33697954638148 0.0963084057454534 no 374 0.0906146566806693 507 5910570 SGTC_2153 5569715 200 µM 1.33469223824602 0.0966927900357033 no 375 0.0909885474860749 499 2054701 SGTC_3033 9090887 49.47 µM 1.33447119330565 0.0967299964692409 no 376 0.0910247407608286 553 19325384 SGTC_554 4483-2211 187 µM 1.33422483860399 0.0967714754468623 no 377 0.0910650907662464 511 747107 SGTC_2497 7-hydroxyflavone 100 µM 1.32953383810531 0.0975637977244993 no 378 0.0918359548366547 474 5281894 SGTC_1835 st008666 49.2 µM 1.3282534668156 0.0977808799599256 no 379 0.0920471933170924 448 690455 SGTC_2862 9027634 71.43 µM 1.3273891764113 0.0979276172621954 no 380 0.0921899891099804 502 5012562 SGTC_2978 9011784 42.97 µM 1.32576649419592 0.0982035484517479 no 381 0.0924585272416322 620 2994934 SGTC_410 α-linolenic acid 100 µM 1.32410060004173 0.0984874197221571 no 382 0.0927348181675055 556 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1718 roemerine 11.9335 µM 1.32014898853332 0.0991631830946393 no 383 0.0933926397340923 605 235224 An aporphine alkaloid with mutagenic activity. SGTC_2630 antimycin a 100 µM 1.31833528973923 0.0994744757632199 no 384 0.0936957162281173 572 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_678 1218-2179 85.9 µM 1.31598996298245 0.0998780721210045 no 385 0.094088705752569 473 6820081 YOR116C RPO31 SGTC_199 4063-0024 41.6 µM 1.31584750068419 0.0999026262697712 no 386 0.0941126162552242 522 306215 SGTC_1104 tacrolimus 29.8 µM 1.31544189837158 0.0999725581693257 no 387 0.0941807160458123 572 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_341 1486-1430 230 µM 1.30792604600313 0.101274878318404 no 388 0.0954491971201748 530 2054753 YPL210C SRP72 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.30723542165741 0.10139516448854 no 389 0.0955663844577925 599 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_391 gliotoxin 8.33 µM 1.30613357721508 0.101587288355672 no 390 0.0957535680913009 577 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.30463191425337 0.101849553500467 no 391 0.0960091078197886 588 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1257 0669-0121 16 µM 1.29929503879842 0.102785625558599 no 392 0.0969213481583893 614 4307855 SGTC_51 1013-0126 23.419 µM 1.29652753971042 0.103273491053809 no 393 0.0973968991732102 521 1627850 SGTC_2085 5307070 144.047 µM 1.29640694652642 0.103294787850745 no 394 0.0974176600559007 494 2840351 SGTC_1900 st060200 72.8 µM 1.29510800129307 0.103524384185404 no 395 0.0976414875532586 550 688945 SGTC_3263 9137018 49.47 µM 1.28964525912402 0.104494010670741 no 396 0.0985869269546449 532 43844957 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.28762391250271 0.104854458529145 no 397 0.0989384556145306 590 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1573 oleylamine 1.06 µM 1.28590779080753 0.105161184377481 no 398 0.0992376222011847 562 5356789 An amine of the fatty acid oleic acid. SGTC_858 0438-0351 2.77 µM 1.28401799485078 0.105499701979991 no 399 0.0995678295835683 585 2799119 SGTC_3199 9111318 49.47 µM 1.28340125081235 0.105610349220745 no 400 0.0996757679484265 546 8548020 SGTC_1834 st055981 52.8 µM 1.28294349347042 0.105692527617872 no 401 0.099755936797728 570 471719 YDL150W RPC53 SGTC_151 3013-0144 2.285 µM 1.27903580008997 0.106395934494727 no 402 0.100442224676216 583 906558 YHR107C CDC12 SGTC_1845 st056753 3.01 µM 1.27729518717746 0.106710340501674 no 403 0.10074902606955 570 5375839 SGTC_263 alizarin 107.927 µM 1.27668794012813 0.106820184830571 no 404 0.100856220410593 642 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3083 9117465 49.47 µM 1.27504198811178 0.107118329707193 no 405 0.101147190379868 555 16420915 SGTC_3261 9137475 49.47 µM 1.27437437421313 0.107239431040679 no 406 0.101265384813992 345 17027690 SGTC_2288 7946289 167.31 µM 1.26942818335847 0.108139717478525 no 407 0.102144194796784 634 1246052 SGTC_1017 4239-0030 168 µM 1.26874923857125 0.108263719799128 no 408 0.102265257450365 601 1149593 SGTC_2264 7948757 110.76 µM 1.26816017892955 0.108371388401624 no 409 0.102370377206967 539 2971411 SGTC_2144 5628481 200 µM 1.26033980082845 0.109808107765172 no 410 0.103773403970599 517 2818399 SGTC_1467 k284-1082 293 µM 1.25839083464022 0.110168280230762 no 411 0.104125222467525 599 3334705 SGTC_198 3454-2873 16.191 µM 1.25694312114069 0.110436368262997 no 412 0.104387116272712 575 710957 SGTC_2351 9026858 72.31 µM 1.25670463193723 0.11048057660124 no 413 0.1044303051236 532 1409300 SGTC_746 1095-0025 46.6 µM 1.25321596804831 0.111128714952683 no 414 0.105063560122642 612 6749286 SGTC_1298 1079-1278 263 µM 1.25245076069601 0.11127124169815 no 415 0.105202829859707 602 2840950 SGTC_49 0717-0965 32.132 µM 1.25109043959516 0.111524936736587 no 416 0.105450741587687 590 5889349 YGL099W LSG1 SGTC_3062 9077494 49.47 µM 1.24899330410254 0.111916855490276 no 417 0.105833761458792 570 16459633 SGTC_1125 tnp00248 1.32998 µM 1.24755664649431 0.112185910052101 no 418 0.106096731705938 709 24207736 SGTC_493 zm226600 134 µM 1.24426836396003 0.112803472759523 no 419 0.106700405159348 597 5240098 A potassium channel opener. YCR052W RSC6 SGTC_191 3914-0123 66.505 µM 1.24420641480501 0.112815130496453 no 420 0.106711801725492 443 3144412 SGTC_136 0097-0015 404.482 µM 1.24294848169035 0.113052037379852 no 421 0.106943409273477 638 4861337 SGTC_2821 7996764 71.43 µM 1.23825482075693 0.113939129067928 no 422 0.107810795084229 627 2987135 SGTC_1667 st014849 34.6 µM 1.23643123538278 0.114285117055104 no 423 0.108149155783408 623 5348460 SGTC_1931 st074438 57.1 µM 1.23605598249849 0.114356406323445 no 424 0.108218877545652 555 2787313 SGTC_2813 7971799 71.43 µM 1.2348552884284 0.114584722818282 no 425 0.108442183147489 559 2234054 SGTC_1723 st034307 2.5525 µM 1.23415794844145 0.114717473470425 no 426 0.10857202682678 584 867466 SGTC_2455 5377712 9.75 µM 1.23120980872597 0.115279911740688 no 427 0.109122201892107 532 2243908 SGTC_735 3076-0345 636 µM 1.23042589040306 0.115429794939979 no 428 0.109268831542913 654 2888990 SGTC_1449 4112-4002 201 µM 1.22191079582957 0.117066786053997 no 429 0.110870681213726 575 2059539 SGTC_2056 5235370 200 µM 1.22148032735408 0.11714997641953 no 430 0.110952104845012 588 5511916 SGTC_2991 9074669 71.4286 µM 1.21601687281743 0.118209458956691 no 431 0.111989247291708 676 17333109 SGTC_2789 5281112 71.43 µM 1.21515878187028 0.118376475136456 no 432 0.112152768826239 615 765948 SGTC_1402 3909-7673 35.9 µM 1.21480279096874 0.118445813043455 no 433 0.112220658061691 590 5328014 SGTC_1913 st060213 96.1 µM 1.20929974366628 0.119521318880251 no 434 0.113273854656203 656 688959 SGTC_1473 k844-0725 134 µM 1.20811514662419 0.119753732733842 no 435 0.11350148718129 702 54682906 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.2079135829333 0.119793310539684 no 436 0.113540252171692 705 688664 SGTC_3127 9126946 49.47 µM 1.2052080199133 0.120325451162331 no 437 0.114061503557717 535 27243249 SGTC_444 curcumin 90.4 µM 1.20379559484849 0.120603913000591 no 438 0.114334296379476 649 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_765 1319-0117 244 µM 1.20315328425995 0.120730695521289 no 439 0.114458504441704 582 3487746 YGL099W LSG1 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.20314251862444 0.120732821296114 no 440 0.114460587085607 653 688801 SGTC_2646 retinol 96.75 µM 1.2027385377028 0.120812610130623 no 441 0.114538757884793 600 445354 A vitamin A analog and teratogen. SGTC_167 3672-0051 66.205 µM 1.20016973747473 0.121320833034918 no 442 0.115036712927833 578 3237971 SGTC_1416 3966-0321 25.3 µM 1.19682359929823 0.121985099894567 no 443 0.115687658944482 639 582530 YLR208W SEC13 SGTC_2651 TUB2.036 5 µM 1.19430789447186 0.122486190536318 no 444 0.116178775333618 801 15992207 YFL037W TUB2 SGTC_2663 amphotericin b 100 µM 1.19021977231042 0.123303560522948 no 445 0.116980011906572 577 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_78 0336-0123 156.75 µM 1.1896001802295 0.123427773104359 no 446 0.117101787496629 572 6765896 SGTC_3325 9138760 55.175 µM 1.18362927360606 0.12462928270173 no 447 0.118279923577332 626 43844959 SGTC_1977 st070720 65.3 µM 1.18196347133239 0.124965941398206 no 448 0.118610097652529 571 682188 SGTC_3155 9099265 49.47 µM 1.18055334880266 0.125251423299027 no 449 0.118890102709604 588 25236499 SGTC_3027 9089541 49.47 µM 1.18040433106829 0.125281618795037 no 450 0.118919720098243 659 9943819 SGTC_996 3970-0799 1.8 µM 1.18001605221804 0.125360319695272 no 451 0.118996915291281 823 6615648 YGL040C HEM2 SGTC_1502 4534-4282 27.7 µM 1.17923299175053 0.125519144522298 no 452 0.119152706139135 601 3278949 SGTC_2237 6667747 47.222 µM 1.17848996747133 0.125669978769887 no 453 0.119300664812855 603 729940 YDL015C TSC13 SGTC_1669 st015249 58.4 µM 1.1784758764672 0.125672840471081 no 454 0.119303472011483 628 722793 SGTC_698 k064-0052 127 µM 1.17760686946391 0.125849412450532 no 455 0.119476684989658 596 5088751 SGTC_1013 4112-3890 241 µM 1.17713976965228 0.125944393090499 no 456 0.119569861948437 653 705171 SGTC_2183 6420625 130.508 µM 1.17496813602767 0.126386632076828 no 457 0.120003732003855 707 2897619 SGTC_1838 st055369 84.5 µM 1.16852981818753 0.12770410809178 no 458 0.121296559373503 590 676036 SGTC_2178 5812956 200 µM 1.16691475494412 0.128036091602469 no 459 0.121622398320583 617 5403383 SGTC_1145 3546-0597 10.2 µM 1.16631357181962 0.1281598204816 no 460 0.121743843960786 674 875334 SGTC_1608 st001473 40.5 µM 1.16455786907373 0.128521635142863 no 461 0.122099003034584 609 7292267 SGTC_2788 5282734 71.43 µM 1.16407610148965 0.128621041493952 no 462 0.122196586323262 718 743706 SGTC_1902 st060212 70.5 µM 1.16379303172919 0.128679474062978 no 463 0.122253948377055 664 688944 SGTC_642 0335-0876 158 µM 1.16334875977504 0.128771219869945 no 464 0.12234401500791 659 6812350 SGTC_3135 9127742 49.47 µM 1.16258918274833 0.128928183863069 no 465 0.1224981108555 604 3643468 SGTC_1768 st044301 37.178 µM 1.16199344167507 0.129051384532163 no 466 0.122619064462226 670 3931349 SGTC_339 3091-4833 71.4 µM 1.16015087211263 0.129432948883248 no 467 0.122993692493469 663 3240077 SGTC_670 4204-0025 119 µM 1.1585222460094 0.129770859477296 no 468 0.123325489359765 683 719039 SGTC_457 grayanotoxin iii 135 µM 1.15769417648804 0.129942903060965 no 469 0.123494430652772 705 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1338 1486-1223 76 µM 1.1558386313352 0.130328992910973 no 470 0.123873584128965 698 3444526 SGTC_200 k038-0079 37.545 µM 1.15435116109146 0.130639068638747 no 471 0.124178114712605 626 3436683 SGTC_719 2810-4230 27.3 µM 1.15272694831736 0.130978231622741 no 472 0.124511238401271 622 721079 SGTC_937 3122-0005 46.7 µM 1.14687804905517 0.132204618139175 no 473 0.125716013026055 715 759535 SGTC_626 0214-0009 33 µM 1.1460693078679 0.132374814475177 no 474 0.125883237903259 686 3437874 SGTC_790 1575-0012 79.1 µM 1.14198551032791 0.133236539323857 no 475 0.126730021297537 695 378741 YLR208W SEC13 SGTC_1775 st081588 35.1725 µM 1.14177234850506 0.133281624496767 no 476 0.126774329478489 698 1426443 YGL099W LSG1 SGTC_2466 5983409 37.09 µM 1.14040126517509 0.133571868821346 no 477 0.127059583018316 642 2879657 SGTC_1129 3453-1384 223 µM 1.14039314771193 0.133573588498597 no 478 0.127061273183489 710 1084452 SGTC_2891 9063876 19.48 µM 1.12857462198718 0.136093492958669 no 479 0.129538660669619 611 6472478 SGTC_1552 6-methylflavone 10.6 µM 1.1270008175745 0.136431492994444 no 480 0.129871067657195 622 689013 SGTC_752 1896-0090 130 µM 1.12405298282087 0.137066132334123 no 481 0.130495274854291 681 772567 SGTC_2396 5342950 42.78 µM 1.12342004228845 0.137202660715437 no 482 0.130629570820643 720 1886677 SGTC_215 1287-0124 461.5 µM 1.12197199398856 0.137515361114846 no 483 0.130937173898509 639 5560863 SGTC_1821 st053465 65.6 µM 1.12050488512138 0.137832673386454 no 484 0.131249336014949 653 675086 SGTC_2687 chenodiol 100 µM 1.12018184244675 0.137902609424103 no 485 0.131318139973173 654 5702181 A cholesterol synthesis inhibitor. SGTC_1485 3909-9022 254 µM 1.12004498013921 0.137932246268416 no 486 0.131347297404253 706 714516 SGTC_1244 0416-0015 52.5 µM 1.11953786979143 0.138042096335598 no 487 0.131455372215084 674 96201 SGTC_2797 7859098 81.82 µM 1.11912328898954 0.13813194700158 no 488 0.131543772826794 687 972681 SGTC_15 0266-0086 27.098 µM 1.11883571549645 0.138194295231881 no 489 0.131605115906228 795 1712902 YIL048W NEO1 SGTC_174 3553-0389 74.3 µM 1.11833001754299 0.138303981118846 no 490 0.131713035582909 622 738071 SGTC_183 3914-0051 30.55 µM 1.11515098763045 0.138994871738606 no 491 0.132392862523111 694 1596232 SGTC_1312 1218-2183 165 µM 1.11334797779014 0.139387757824482 no 492 0.132779504146248 723 6744073 SGTC_1163 k060-0048 49.9 µM 1.11328757450491 0.139400933109469 no 493 0.132792470615358 737 6809982 SGTC_6 0844-0013 19.835 µM 1.11263120863228 0.139544155562664 no 494 0.132933425593239 926 1584900 SGTC_460 trequinsin 123 µM 1.11261411271473 0.139547887317706 no 495 0.132937098328067 757 5537 A vasodilator. SGTC_1572 epiandrosterone 68.9 µM 1.11256062342629 0.139559563579928 no 496 0.132948589942147 747 441302 A steroid. SGTC_343 4130-2827 29.8 µM 1.11056936680888 0.139994710967431 no 497 0.133376877280232 716 1118244 SGTC_2772 vinpocetine 57.06 µM 1.11056254289019 0.139996203775245 no 498 0.133378346625627 683 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2038 4100038 30.985 µM 1.10889558745716 0.140361192828885 no 499 0.133737613804349 716 3596803 SGTC_2893 9048488 25.97 µM 1.10793238667522 0.140572385235419 no 500 0.133945508686699 672 6467338 SGTC_402 epigallocatechin gallate 10 µM 1.10556958523991 0.141091368707173 no 501 0.134456430151698 721 65064 An antioxidant. SGTC_1119 parthenolide 318.541 nM 1.1004259821818 0.14222563659647 no 502 0.13557328154251 778 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1220 1838-0075 193 µM 1.09625598659299 0.143149721593842 no 503 0.136483382389524 723 5529645 SGTC_3330 9141424 71.43 µM 1.09560900547895 0.143293457408847 no 504 0.136624959505291 756 27261020 SGTC_1360 1598-0022 39.8 µM 1.09522590311658 0.143378614833095 no 505 0.136708840074045 785 761525 SGTC_1828 st055811 49 µM 1.09261623681691 0.143959610322598 no 506 0.137281165357181 675 5877589 SGTC_1374 2889-5571 141 µM 1.09244266837006 0.14399830846947 no 507 0.137319288563733 752 2853281 SGTC_126 0417-1624 672.48 µM 1.08798757243894 0.14499400069911 no 508 0.138300296933493 854 41912 YDL195W SEC31 SGTC_3292 9120825 59.784 µM 1.08730124204623 0.145147803201682 no 509 0.138451849937606 732 24824900 SGTC_125 0133-0007 11.75 µM 1.08367763727068 0.145961650807754 no 510 0.139253877124554 777 26541 SGTC_913 3487-1245 167 µM 1.08254481737039 0.146216705679992 no 511 0.139505256134698 695 4016153 SGTC_1774 st048371 48.465 µM 1.08200236109206 0.146338945858627 no 512 0.13962573940374 735 4242727 SGTC_1191 1487-1166 10.6 µM 1.07974121773095 0.146849223729606 no 513 0.140128716918282 809 3955771 SGTC_2849 9019321 12.99 µM 1.07925916122968 0.146958164792033 no 514 0.140236106424366 682 16489627 SGTC_1737 st035557 69.7 µM 1.07813098088153 0.147213336691819 no 515 0.140487653776254 606 5716916 SGTC_840 0245-0196 390 µM 1.07591626105448 0.147715125503798 no 516 0.140982354383131 782 3827528 SGTC_1044 1222-0021 1.78 µM 1.07492896684202 0.147939185335266 no 517 0.141203265990857 727 4306703 SGTC_2508 celastrol 40.54 µM 1.07308420246836 0.148358451703756 no 518 0.141616669135578 676 122724 Celastrol is a natural product and antioxidant. SGTC_1165 k072-0275 30.3 µM 1.07292354093125 0.148395003426336 no 519 0.141652711416191 719 6153523 YGL055W OLE1 SGTC_3264 9137442 49.47 µM 1.07129627213563 0.148765558897683 no 520 0.142018117743666 687 17015726 SGTC_3184 9108758 49.47 µM 1.0687935801292 0.149336668424228 no 521 0.142581346389823 739 902885 SGTC_3016 9080866 49.47 µM 1.06839546481794 0.149427652340845 no 522 0.142671080954488 752 17066299 SGTC_807 1315-0151 48 µM 1.06776210934255 0.149572473484394 no 523 0.142813916960128 815 4011080 SGTC_1879 gemcitabine 100 µM 1.06705534475252 0.149734190674718 no 524 0.142973422461757 749 60750 A nucleoside analog which inhibits DNA replication. SGTC_884 0851-0618 334 µM 1.06512589901392 0.150176267343497 no 525 0.143409480321127 756 9642473 SGTC_75 0159-0059 199.013 µM 1.0651125427676 0.150179330569787 no 526 0.143412501980537 707 5377270 SGTC_3179 9107801 49.47 µM 1.06408123363529 0.150415984861017 no 527 0.143645950710698 727 4818259 SGTC_557 1315-0110 16.2 µM 1.06390809369454 0.150455739591202 no 528 0.143685168063343 740 6833801 SGTC_784 4579-0127 173 µM 1.06302392659778 0.150658862682619 no 529 0.143885550467541 787 1948547 SGTC_192 3455-0609 60.9 µM 1.06095403192945 0.151135101389101 no 530 0.144355396097413 735 3769639 SGTC_1637 st007924 17.4 µM 1.05824655669386 0.151759544111563 no 531 0.144971525459376 730 683336 SGTC_2248 tofa 1.1 µM 1.05434533763318 0.152662318690687 no 532 0.145862419357996 720 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_288 1315-0019 35.1 µM 1.0531740326458 0.152934062381192 no 533 0.146130618699645 770 6811474 SGTC_470 aa-861 153 µM 1.05199986301965 0.153206792367466 no 534 0.146399806238519 771 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3085 9117376 49.47 µM 1.05038325235499 0.153582817285695 no 535 0.146770971230844 739 16480349 SGTC_2406 ethylparaben 405.7 µM 1.04823386456704 0.154083712247932 no 536 0.147265435845955 646 8434 A possible steroid mimic. SGTC_1219 1469-0211 33.1 µM 1.04782508422388 0.154179096905281 no 537 0.147359601596333 735 6822282 SGTC_837 0091-0265 12.5 µM 1.04378918070281 0.155122929127082 no 538 0.148291469180798 786 759367 SGTC_2208 7283366 200 µM 1.04297715206947 0.155313289297722 no 539 0.148479437391318 775 898663 SGTC_1418 3966-3099 2.4 µM 1.03994230928969 0.156026097927858 no 540 0.149183352112219 780 740335 SGTC_1029 k015-0030 64.7 µM 1.03741524348921 0.156621285003905 no 541 0.149771188603712 748 2208316 SGTC_2293 7624732 200 µM 1.03713701703552 0.156686905495092 no 542 0.149836002883458 693 894453 SGTC_1574 spiramycin 23.7 µM 1.03628088246897 0.156888940739842 no 543 0.150035561161372 756 6419898 An antibiotic and protein synthesis inhibitor. SGTC_7 0192-1582 4.227 µM 1.03623492661429 0.156899790494926 no 544 0.150046278121007 863 252616 SGTC_1100 amiodarone 5.07 µM 1.03596308507902 0.156963979880561 no 545 0.150109682326861 816 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2089 5281248 129.67 µM 1.03586255103282 0.156987723154511 no 546 0.150133135369155 774 2737878 SGTC_390 dec-rvkr-cmk 16.7 µM 1.03563455241158 0.157041578679451 no 547 0.150186332981654 795 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3236 9132701 49.47 µM 1.03295160426524 0.157676230290877 no 548 0.150813273660623 761 24282524 SGTC_449 xestospongin c 11.1929 µM 1.03159025443394 0.15799890119103 no 549 0.151132053863336 798 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3299 9121982 43.1275 µM 1.02988397158311 0.158403940832976 no 550 0.151532237882119 770 17594604 YPL160W CDC60 SGTC_2246 7293507 91.5585 µM 1.02933043274242 0.15853548680501 no 551 0.151662213632142 803 887656 SGTC_798 1287-0182 476 µM 1.0271158675289 0.15906248457117 no 552 0.152182953918403 858 1649755 SGTC_3230 9131665 49.47 µM 1.02641556702299 0.159229372930108 no 553 0.152347871704871 652 15943720 SGTC_2091 4-phenylthiadiazole 200 µM 1.02600345998995 0.159327635587512 no 554 0.152444976580735 794 270010 SGTC_971 1315-0384 26.7 µM 1.02246987036779 0.160171813009252 no 555 0.153279282915298 747 6769120 SGTC_2464 5717415 7.67 µM 1.02133603630289 0.160443305394323 no 556 0.153547629344618 752 5285744 SGTC_2742 clothiapine 36.27 µM 1.02117329741994 0.16048229727999 no 557 0.153586170548156 730 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3170 9103054 49.47 µM 1.01974578307889 0.160824591948919 no 558 0.153924521143223 728 16432970 SGTC_900 1112-0045 141 µM 1.01932992189158 0.160924398273279 no 559 0.154023181604477 648 56211 YIL048W NEO1 SGTC_1700 st030840 7.9285 µM 1.0184334626551 0.161139685200399 no 560 0.154236003222131 819 5499307 SGTC_256 clotrimazole 625 nM 1.01831088885144 0.161169136203223 no 561 0.154265117649877 762 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1786 berberine 21.6 µM 1.01583035706067 0.161765892120544 no 562 0.154855088658353 748 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3223 9129970 49.47 µM 1.01541823721045 0.161865177494704 no 563 0.154953251653828 807 17248386 SGTC_1202 1988-0068 29.6 µM 1.01514916165831 0.161930022937451 no 564 0.155017365040007 787 2850480 SGTC_640 3381-0960 37.1 µM 1.01504246276334 0.161955741356465 no 565 0.155042793334606 831 1745025 SGTC_1266 0828-0227 32.9 µM 1.01445398535884 0.162097634196496 no 566 0.155183087727193 746 3913820 SGTC_892 0929-0076 29 µM 1.01419460264089 0.162160201889598 no 567 0.155244951776643 801 5751038 SGTC_3002 9075603 71.4286 µM 1.01253728347309 0.162560347737249 no 568 0.15564061476893 796 20105405 SGTC_1162 k048-0130 20.1 µM 1.01061978297357 0.163024113147216 no 569 0.156099221798978 786 6797406 SGTC_2925 9010536 32.5 µM 1.01030629416557 0.163100015062663 no 570 0.156174283266886 847 2994177 SGTC_1024 4507-0395 26 µM 1.00955429846407 0.16328218189008 no 571 0.156354437344846 758 4201836 SGTC_963 1269-2853 151 µM 1.0089425479045 0.163430472575373 no 572 0.156501094105397 746 3668223 SGTC_2062 5245942 200 µM 1.00758526348438 0.163759795769907 no 573 0.1568268032045 833 1376160 SGTC_2012 4023501 200 µM 1.00733935053023 0.163819508645082 no 574 0.156885862913269 721 3477460 SGTC_274 sirtinol 40.1 µM 1.00550327437675 0.164265793411724 no 575 0.157327286790985 792 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1671 st016596 74.5 µM 1.00340719213862 0.16477623921252 no 576 0.157832217692406 845 2829167 SGTC_65 0798-0905 34.986 µM 1.00228238205696 0.16505058035473 no 577 0.158103614536116 882 3602145 SGTC_1272 0839-0021 27 µM 1.00105611871104 0.16535000267609 no 578 0.15839983906721 813 5027250 SGTC_2979 9012552 45.46 µM 1.00104950727772 0.165351617971943 no 579 0.15840143715626 753 17100905 SGTC_688 0527-0193 473 µM 0.999545690787328 0.165719293518204 no 580 0.158765208431801 787 4007154 SGTC_237 nikkomycin 200 µM 0.9982980904167 0.16602472638536 no 581 0.159067416659871 834 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_172 1112-0046 2.638 µM 0.997482355169642 0.166224628188798 no 582 0.159265217144343 721 2802135 YIL048W NEO1 SGTC_121 0557-0495 61.343 µM 0.995993025084096 0.166590000115917 no 583 0.15962676707237 1008 3104427 SGTC_95 0471-0001 561.058 µM 0.995355702287292 0.166746510445492 no 584 0.159781647598415 763 4015405 SGTC_1102 cgs 12066b 26.1 µM 0.993695369861097 0.167154691394255 no 585 0.160185598791972 771 6438352 A 5-HT1B full agonist. SGTC_2502 avocadyne acetate 18.59 µM 0.993148607451961 0.167289249930625 no 586 0.160318769549821 879 3952079 SGTC_2072 5231554 129 µM 0.987429566589921 0.168700891617156 no 587 0.161716047904811 875 789545 SGTC_3008 9078912 71.4286 µM 0.981513194622711 0.170169273142912 no 588 0.163169865454927 794 16648731 SGTC_2561 acetosyringone 100 µM 0.981277598899831 0.170227914590041 no 589 0.163227933197348 932 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1283 0922-0125 16.4 µM 0.979535252531283 0.170661998843984 no 590 0.163657789534657 875 3360884 SGTC_2223 6903751 107.57 µM 0.974886106026959 0.17182374115465 no 591 0.164808379386655 775 5598863 SGTC_1242 0402-0103 60.1 µM 0.974585725634405 0.171898974381539 no 592 0.164882898530776 767 432868 SGTC_3153 9100258 49.47 µM 0.973251855390587 0.172233309351295 no 593 0.165214072065129 752 25236848 SGTC_2128 5255449 168.493 µM 0.973006115097399 0.172294949461268 no 594 0.165275131437919 858 736008 SGTC_1452 4194-0072 190 µM 0.972850879884371 0.172333895039956 no 595 0.165313710434803 899 1343545 SGTC_1761 st044296 37 µM 0.970251414553373 0.172986886002215 no 596 0.165960594245079 821 1826700 SGTC_1800 st050079 29.0735 µM 0.968657865011353 0.173387967224791 no 597 0.166357960946124 926 3645560 SGTC_1478 0453-0656 35.7 µM 0.967144286449446 0.17376946822066 no 598 0.166735954540401 851 5258496 SGTC_2027 5150920 200 µM 0.96652389386141 0.173925993775637 no 599 0.166891048305627 820 786715 SGTC_1904 st060225 78 µM 0.966344034660722 0.173971389156933 no 600 0.166936029229658 826 66595 SGTC_2369 9071472 200 µM 0.962568820334905 0.174925968723871 no 601 0.167881975489994 862 17296037 SGTC_1504 k297-0033 30 µM 0.961129800749252 0.175290704435842 no 602 0.168243453687877 708 4388117 SGTC_1935 st074532 41.6 µM 0.959744912052103 0.175642175085753 no 603 0.168591806765096 921 2829742 SGTC_1520 flindersine 88 µM 0.958361653935404 0.175993677336286 no 604 0.16894021218806 865 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_60 0986-0278 202 µM 0.957747289172366 0.176149937432896 no 605 0.169095102330725 708 3110598 SGTC_3112 9123419 49.47 µM 0.957100499975038 0.176314539357109 no 606 0.169258265646135 893 17015854 SGTC_2367 9070478 135.38 µM 0.956818063505431 0.17638644736966 no 607 0.169329546629011 833 572802 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.955035882244602 0.176840616567907 no 608 0.169779775739288 858 2724 A muscle relaxant with antifungal properties. SGTC_2127 5253358 187.912 µM 0.954460653729627 0.176987364846609 no 609 0.169925258372069 753 20612 SGTC_1185 1319-0113 81.3 µM 0.954447812487865 0.176990641692275 no 610 0.169928506997717 810 4672763 SGTC_3015 9080845 49.47 µM 0.95380858400835 0.177153809340858 no 611 0.170090271745288 904 5296973 SGTC_2477 5967686 25.23 µM 0.951795428101832 0.177668302381729 no 612 0.170600370575838 830 776118 SGTC_2914 7968218 45.32 µM 0.95056496306157 0.177983230460159 no 613 0.170912630845276 804 2977111 SGTC_1064 honokiol 6.76 µM 0.949760480611343 0.178189321749067 no 614 0.171116985301557 856 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1022 4477-0945 21.3 µM 0.947200520461208 0.178846129407749 no 615 0.171768305111071 842 4648966 SGTC_2469 5655019 90.81 µM 0.946268997387061 0.179085507462508 no 616 0.172005700977899 916 2788239 SGTC_949 1165-0505 146 µM 0.942924288644913 0.179946673843893 no 617 0.172859815173838 899 6244267 SGTC_785 1270-0111 65.3 µM 0.942694744958226 0.180005869954247 no 618 0.172918531037575 878 6741994 SGTC_886 0866-0150 153 µM 0.940168917261082 0.180658052966055 no 619 0.173565461349464 927 271463 SGTC_2587 piperic acid 92.2 µM 0.939243447857952 0.180897384845754 no 620 0.173802883238116 780 5370536 SGTC_577 r071-0003 38.6 µM 0.937575029462345 0.181329349504162 no 621 0.174231424441858 1002 4568517 YMR134W ERG29 SGTC_893 0958-0369 48.9 µM 0.937405799474448 0.181373200327674 no 622 0.174274929447031 889 6819948 SGTC_297 0986-0032 24 µM 0.934847005550322 0.182037043208815 no 623 0.174933575580579 846 2847425 SGTC_1082 camptothecin 424.86 nM 0.93324525164362 0.182453367703731 no 624 0.1753466777176 771 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2552 juarezic acid 87.02 µM 0.932833763926994 0.182560416675163 no 625 0.175452902695056 1031 1549512 SGTC_810 3825-7150 143 µM 0.931916758364298 0.182799117733069 no 626 0.175689773102333 930 22330411 YGL099W LSG1 SGTC_1240 0356-0016 42.1 µM 0.931552241823435 0.182894057271355 no 627 0.175783987103864 847 4305613 SGTC_1903 st060211 78.3 µM 0.927873172965285 0.183854004927172 no 628 0.176736680857899 927 688960 SGTC_3097 9117246 49.47 µM 0.923894402747107 0.184895675987236 no 629 0.177770648787223 884 16423892 SGTC_190 3970-0790 3.722 µM 0.923402304169124 0.185024765369104 no 630 0.177898795702722 864 2832352 SGTC_656 4090-1979 187 µM 0.922465296424125 0.185270719977509 no 631 0.178142962017113 952 22330961 SGTC_1401 3807-4679 7.6 µM 0.921214224433444 0.185599429455275 no 632 0.178469296618744 857 3291456 SGTC_3078 9116413 49.47 µM 0.920517441433646 0.185782660597787 no 633 0.178651211437789 868 17177322 SGTC_3283 9109332 35.8195 µM 0.920246747257399 0.185853874565825 no 634 0.178721915254019 796 17027281 SGTC_1333 1482-0047 286 µM 0.920098078901151 0.185892993297707 no 635 0.178760754097246 936 3811116 SGTC_94 0334-0113 514.748 µM 0.919590618772119 0.186026558464927 no 636 0.178893365464032 897 6795178 SGTC_1457 k015-0032 57.3 µM 0.919091140436758 0.186158080881216 no 637 0.179023951444403 878 4302660 SGTC_2938 9059746 27.26 µM 0.917051474154062 0.186695762881881 no 638 0.179557833776851 845 6471769 SGTC_2071 5230951 39.92 µM 0.915994966387003 0.186974649363166 no 639 0.17983476750844 955 1799272 SGTC_1376 2910-0861 41.3 µM 0.91247032553648 0.187906912094862 no 640 0.180760591867875 927 1112859 SGTC_383 2324-0395 7.37 µM 0.909353360815206 0.188733731939475 no 641 0.181581816078237 918 3146421 SGTC_649 1123-0311 367 µM 0.90904649994611 0.1888152522813 no 642 0.18166279052713 934 693629 YIL048W NEO1 SGTC_2033 5192550 145 µM 0.90731847635192 0.189274722281004 no 643 0.182119203176173 874 182073 SGTC_2129 girgensonine 121.053 µM 0.906998702806455 0.189359823356711 no 644 0.182203741603104 947 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2868 9035608 32.47 µM 0.906911310552184 0.189383085084026 no 645 0.182226849731391 900 6462614 SGTC_1315 1237-0019 3.69 µM 0.905413482186437 0.189782044513468 no 646 0.182623187931595 940 825140 SGTC_1278 0874-0585 172 µM 0.905390673605602 0.189788123766982 no 647 0.182629227435194 903 766306 SGTC_2892 9047358 58.44 µM 0.904982916985572 0.189896824819202 no 648 0.182737218703543 838 6466771 SGTC_1789 tunicamycin 25 nM 0.904145612204161 0.190120156150734 no 649 0.182959097516846 902 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2173 5763948 167 µM 0.902762911650163 0.190489312126131 no 650 0.183325869530757 925 2867177 SGTC_1349 flufenamic acid 69 µM 0.900050329117266 0.191214800024146 no 651 0.184046733814315 876 3371 A non-steroidal anti-inflammatory. SGTC_2976 9009005 19.48 µM 0.899681839516119 0.191313484131097 no 652 0.184144795278996 919 2993148 SGTC_2381 9035592 200 µM 0.899376464010118 0.191395289488707 no 653 0.184226085628334 836 4749657 SGTC_1910 st062352 60.4 µM 0.898283679895136 0.191688204952326 no 654 0.184517165487822 936 2245730 SGTC_2694 st077685 81.9 µM 0.896849322943925 0.192073093758817 no 655 0.184899662387583 881 2838096 SGTC_633 0437-0093 97.7 µM 0.89675915670532 0.19209730434353 no 656 0.184923723275319 916 2831118 SGTC_2161 5662504 8.5105 µM 0.894402785951347 0.192730676572932 no 657 0.185553211206452 863 2859334 SGTC_1605 st000082 49.1 µM 0.89363079198842 0.192938459111414 no 658 0.185759732842566 932 1114022 SGTC_3043 9092303 49.47 µM 0.893367362128463 0.193009392678324 no 659 0.185830237467691 879 25236084 SGTC_2259 7964009 200 µM 0.891936949882484 0.19339483667748 no 660 0.186213364066316 854 313134 SGTC_534 k292-0788 63.4 µM 0.890708432831445 0.193726251881168 no 661 0.186542804795022 1010 4146317 SGTC_3138 9097216 49.47 µM 0.889872629918361 0.193951922978752 no 662 0.186767140963956 1000 25237486 SGTC_2571 chrysanthemic acid 100 µM 0.889700324683796 0.193998466190042 no 663 0.186813409816457 852 2743 An insecticide. SGTC_138 0850-0259 40.9225 µM 0.889134689919794 0.1941513036851 no 664 0.186965348689586 982 6813004 SGTC_2856 9022925 19.48 µM 0.887385442062804 0.194624423613119 no 665 0.187435709294961 904 4944862 SGTC_2778 tioconazole 65.09 nM 0.886346361154646 0.194905796176877 no 666 0.187715456890668 872 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2253 7938677 135.83 µM 0.88627557546736 0.194924973218125 no 667 0.18773452361671 935 2301972 SGTC_44 0929-0055 61.211 µM 0.885195774604966 0.195217651781902 no 668 0.188025525439128 864 1379590 SGTC_139 0099-0334 718.624 µM 0.883807421358345 0.195594355227474 no 669 0.188400089752694 1058 97690 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.882816089587768 0.195863604285336 no 670 0.188667822933629 962 6728940 SGTC_1084 voriconazole 435 nM 0.88190626807381 0.196110912708949 no 671 0.188913748588914 972 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1812 st052057 4.327 µM 0.880784201374275 0.196416174464434 no 672 0.189217316175119 976 3645418 SGTC_114 0364-0001 490.298 µM 0.88073400139042 0.196429838253963 no 673 0.189230904458081 914 4003655 SGTC_782 0083-0095 30.5 µM 0.88059462487042 0.196467777768872 no 674 0.189268634464285 976 3591729 An indicator and reagent. SGTC_1623 st003709 20.3 µM 0.88012801987285 0.196594824069223 no 675 0.189394980758758 950 16192618 SGTC_2186 6124449 200 µM 0.879644765825599 0.196726455994777 no 676 0.189525889955152 919 3834182 YLR033W RSC58 SGTC_1280 0880-0253 10.1 µM 0.873737900119118 0.198339717269787 no 677 0.191130503005101 933 6836607 SGTC_2282 7944268 200 µM 0.873293975750782 0.198461281950718 no 678 0.191251431645672 948 2970414 SGTC_3077 9117319 49.47 µM 0.871451149985566 0.19896640358681 no 679 0.191753933788009 934 17154678 SGTC_914 3820-6779 408 µM 0.87113648945437 0.199052729941273 no 680 0.191839816228033 956 2893481 SGTC_2982 9019404 25.97 µM 0.870403201242228 0.199253993341487 no 681 0.192040048933895 879 22333232 SGTC_1522 st012842 45.6 µM 0.868943392059737 0.199655027429141 no 682 0.192439047025105 842 3491067 YOR116C RPO31 SGTC_2617 dihydrotanshinone i 20.83 µM 0.867750961492227 0.199982968227796 no 683 0.192765340445551 974 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2740 felodipine 17.08 µM 0.864878402085846 0.200774304747575 no 684 0.193552766531871 898 3333 L-type calcium channel blocker SGTC_61 0978-8327 98.565 µM 0.863823461914391 0.201065392276379 no 685 0.193842438611423 1015 6150059 YHR072W ERG7 SGTC_1814 st052110 31.539 µM 0.863555710936067 0.201139312524046 no 686 0.19391600137576 959 674163 SGTC_742 0kpi-0133 140 µM 0.862706191377853 0.201373954341713 no 687 0.194149513711109 976 2728852 SGTC_2699 st077704 54.6 µM 0.861679137940715 0.201657850930692 no 688 0.194432054408243 935 645852 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.860210014167447 0.202064360421937 no 689 0.194836642742464 970 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1379 2144-0755 36.5 µM 0.859912700276568 0.202146687395678 no 690 0.194918583551788 1020 5392327 SGTC_3191 9110352 49.47 µM 0.858706305476453 0.202480947067052 no 691 0.195251285396294 940 17122424 SGTC_1862 st057513 3.81 µM 0.858015666781547 0.202672453193594 no 692 0.195441906266864 986 5393163 SGTC_2263 7948595 193.29 µM 0.858001104964475 0.20267649218199 no 693 0.195445926641558 890 2971371 SGTC_2659 sanguinarine 24.21 µM 0.857741229036414 0.202748581650289 no 694 0.19551768428041 914 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1190 1486-1332 13 µM 0.853749430516867 0.203857828758598 no 695 0.19662191967014 963 4150046 SGTC_1366 1683-0113 21.9 µM 0.85350628969109 0.203925509767381 no 696 0.19668930059809 958 708623 SGTC_2900 5328528 85.29 µM 0.850221579053114 0.204841157935491 no 697 0.197600953295511 1050 795359 SGTC_2391 6285546 200 µM 0.848465605920713 0.205331655435628 no 698 0.198089359592657 1001 846083 SGTC_1477 0139-0234 16 µM 0.847568783647492 0.205582434492622 no 699 0.198339082662645 986 620880 SGTC_2440 5628896 157.78 µM 0.847563740567046 0.205583845206746 no 700 0.198340487461709 962 5522048 SGTC_1749 st037932 54.2 µM 0.84472996336941 0.206377453679691 no 701 0.199130812991601 914 594497 SGTC_1732 st034308 51.822 µM 0.842520255900035 0.206997547230884 no 702 0.19974840321234 920 830119 SGTC_349 k015-0014 24 µM 0.840125075047466 0.207670932389451 no 703 0.200419131086995 917 2196908 SGTC_770 0389-1121 67.2 µM 0.839933130789935 0.20772495187482 no 704 0.200472940156116 1035 6753108 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.837827521126481 0.208318085099232 no 705 0.20106378983934 1007 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_904 1141-0088 396 µM 0.837753742281075 0.208338886104493 no 706 0.201084511652854 966 1378119 SGTC_3167 9103034 49.47 µM 0.836694208837493 0.208637743171482 no 707 0.201382237594017 958 5127859 SGTC_1917 st066507 28.5 µM 0.836489546418634 0.208695500339402 no 708 0.201439777594465 984 3156428 SGTC_1622 st003707 19.4 µM 0.835933226566636 0.208852545313224 no 709 0.201596234424216 1009 10140899 SGTC_2289 7946404 165.07 µM 0.834819489477106 0.209167154191003 no 710 0.201909675381475 1040 1246120 YPR165W RHO1 SGTC_2798 7813637 45.45 µM 0.834682694698587 0.209205815262742 no 711 0.201948193880091 959 956368 SGTC_1448 4255-0083 152 µM 0.834564023780652 0.209239357558973 no 712 0.201981612648065 1043 5399660 SGTC_294 k038-0071 157 µM 0.833421956947593 0.20956232417552 no 713 0.202303397836925 1003 24152826 SGTC_1936 st074407 74.3 µM 0.833242548467552 0.209613085977281 no 714 0.202353975263523 1050 809813 SGTC_2328 6201408 200 µM 0.83136965991386 0.210143432360256 no 715 0.202882416650952 931 2890418 SGTC_1733 st037357 54.9 µM 0.829847377410689 0.210575077640959 no 716 0.203312540124621 994 1272339 YGL099W LSG1 SGTC_2531 methyl deoxycholate 70.07 µM 0.829051883656254 0.210800847805603 no 717 0.203537524534506 963 16667744 Haematoxylin. SGTC_772 k072-0172 35.3 µM 0.828630009925351 0.210920637950602 no 718 0.20365690061623 936 5861980 SGTC_1281 0884-0031 11.8 µM 0.828469673898936 0.210966175488131 no 719 0.203702281267207 1000 1548255 SGTC_2586 curcumin 80 µM 0.827389570876653 0.211273089100422 no 720 0.204008144921443 1053 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_175 3793-3120 23.7 µM 0.826475755220866 0.211532955953913 no 721 0.204267132862965 979 5322297 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.826451550067691 0.211539841851542 no 722 0.204273995597166 1043 165521 SGTC_3050 9093513 49.47 µM 0.824902442417287 0.211980805900183 no 723 0.204713489796463 1054 25236664 SGTC_1442 4112-3290 3 µM 0.82393633707174 0.212256086356624 no 724 0.204987866137348 1044 704353 SGTC_2733 amorolfine 100 µM 0.823149062200887 0.212480565586294 no 725 0.205211615748877 987 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2325 6158266 200 µM 0.821854487115831 0.212849994991469 no 726 0.205579859343168 984 3623240 SGTC_706 4262-0057 46.9 µM 0.820011343725195 0.213376614189135 no 727 0.20610482022673 1023 883298 SGTC_2917 7979103 53.79 µM 0.818660116310408 0.213763166211431 no 728 0.206490178922184 1031 2980565 SGTC_2700 st077718 96.8 µM 0.817750644852609 0.214023572498313 no 729 0.206749792697791 955 904970 SGTC_1007 4101-0031 70 µM 0.816592191322756 0.214355536330261 no 730 0.207080759513493 1039 1146276 SGTC_2364 9055074 200 µM 0.814343877745472 0.215000661885136 no 731 0.207723989946357 1004 6470630 SGTC_2375 9072683 200 µM 0.81407826033404 0.215076951888418 no 732 0.207800059538232 1100 16798029 SGTC_1971 st069429 63.5 µM 0.813398826111588 0.2152721688805 no 733 0.207994716079345 1048 1246522 YGL099W LSG1 SGTC_2047 4141938 200 µM 0.811003897336625 0.215961106204313 no 734 0.208681716311271 974 3807862 SGTC_77 0828-0286 12.516 µM 0.809312504734745 0.216448429451594 no 735 0.209167707631367 1046 745345 SGTC_89 0302-0250 142.109 µM 0.809121176408389 0.216503594915369 no 736 0.209222724313853 1134 4203518 YLR208W SEC13 SGTC_1438 4092-1045 4 µM 0.807584991976613 0.216946815891761 no 737 0.209664764615284 1041 1351342 SGTC_3232 9132874 49.47 µM 0.806963273459512 0.217126343512528 no 738 0.209843821427822 1009 3784940 SGTC_614 0462-0418 107 µM 0.806591349094026 0.217233781519989 no 739 0.209950979726148 950 5188303 SGTC_1342 1486-1464 234 µM 0.806317644343597 0.217312866380104 no 740 0.210029859670932 1052 3253938 SGTC_1518 st038567 90.8 µM 0.806188435230334 0.217350206125472 no 741 0.210067102954044 1042 77966 SGTC_316 k060-0003 58.6 µM 0.805349918068598 0.217592616646782 no 742 0.210308891730809 1014 6152314 SGTC_3130 9127414 49.47 µM 0.805011340512133 0.217690541686336 no 743 0.210406567813587 1047 1494646 SGTC_2340 7987427 183.45 µM 0.802957608011014 0.218285076773494 no 744 0.210999618598555 974 2239331 SGTC_2855 9016525 58.44 µM 0.801710244457811 0.218646632264274 no 745 0.211360294229278 1079 43811474 SGTC_2852 9023854 51.95 µM 0.800541331795718 0.218985760983869 no 746 0.211698613294189 1033 19798528 SGTC_2838 9002687 71.43 µM 0.798928403803199 0.219454205242928 no 747 0.21216596399142 971 6457060 SGTC_1925 st057770 10.1 µM 0.798028393603025 0.21971584613616 no 748 0.212427006607698 979 5989122 SGTC_229 benomyl 22.8748 µM 0.797993189899079 0.21972608380136 no 749 0.212437221045167 1038 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1479 0549-0158 134 µM 0.797311068530157 0.219924507048849 no 750 0.212635196805855 1109 5440202 SGTC_135 0933-0004 26.348 µM 0.796975370367851 0.220022196503236 no 751 0.212732667839075 968 21230617 YGL099W LSG1 SGTC_2680 butyl paraben 22.24 µM 0.796648998171449 0.220117195928771 no 752 0.212827456052782 1068 7184 An antifungal and steroid mimetic. SGTC_2781 5567276 71.43 µM 0.796455548125471 0.220173515883061 no 753 0.21288365134714 1014 2853274 SGTC_1864 st057645 30.4 µM 0.796270913052058 0.220227277203191 no 754 0.212937294056629 1085 688666 SGTC_3148 9097893 49.47 µM 0.795669811974812 0.220402355605717 no 755 0.213111988804755 1014 17174100 SGTC_42 0133-0086 60.653 µM 0.795390204025136 0.220483822187441 no 756 0.213193278227866 1025 162923 Model of phenazepam hydroxylation. SGTC_1500 4488-1866 171 µM 0.793964852632099 0.220899380721192 no 757 0.213607946519144 1111 2900003 SGTC_313 3474-0040 5.03 µM 0.793624770849702 0.2209985971426 no 758 0.213706953710612 1049 1043375 YIL048W NEO1 SGTC_1308 1187-1617 41.4 µM 0.79343319830708 0.221054498286853 no 759 0.213762737532169 1073 2882570 SGTC_431 k089-0097 107 µM 0.793415473958867 0.221059670686164 no 760 0.213767899096393 1044 5499420 SGTC_696 1560-0013 611 µM 0.793347374924415 0.221079544298065 no 761 0.213787731109568 1052 1650269 SGTC_489 paxilline 115 µM 0.793178200664044 0.221128919519412 no 762 0.21383700320234 1036 105008 A toxic potassium channel blocker. SGTC_1488 4013-0813 75.9 µM 0.792658889744955 0.22128052507556 no 763 0.213988294080639 1012 2910057 SGTC_3075 9116269 49.47 µM 0.790002002369472 0.222057095671271 no 764 0.214763299464646 1049 17015205 YNL244C SUI1 SGTC_324 1315-0088 19.6 µM 0.789890431043875 0.222089740393869 no 765 0.214795880097636 1001 6787421 SGTC_1038 k292-0204 154 µM 0.78611748027797 0.223195281882764 no 766 0.215899332173699 1010 4454212 SGTC_1128 3448-9350 235 µM 0.785002624014516 0.223522553169265 no 767 0.216226015053264 957 619386 SGTC_207 4185-0010 4.486 µM 0.783258779503137 0.224035013898092 no 768 0.216737581960847 1141 3761753 SGTC_3282 9108498 15.4605 µM 0.783117220224913 0.224076642960281 no 769 0.216779139888526 1012 16459645 SGTC_2854 9024559 71.43 µM 0.783029009036302 0.224102585898357 no 770 0.216805038607971 1048 3163529 SGTC_1530 rhein 70.4 µM 0.782161680181421 0.22435775842032 no 771 0.217059780775232 1127 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_160 3453-0671 289.699 µM 0.780894258264329 0.224730936761816 no 772 0.217432344682821 1098 5322268 SGTC_2339 9000433 200 µM 0.779233617420177 0.225220426407466 no 773 0.217921055239598 1022 2988954 SGTC_2015 5119600 184 µM 0.775955993730712 0.226188307075454 no 774 0.21888748478842 1071 2828786 SGTC_1615 st002656 86.5 µM 0.775370325561438 0.226361501767769 no 775 0.219060432301807 1078 1584458 SGTC_1372 2752-0194 270 µM 0.773300789300606 0.2269741078233 no 776 0.21967219438267 1016 823334 SGTC_2795 7780010 54.55 µM 0.773067861866823 0.227043115457048 no 777 0.219741109904093 1024 953673 SGTC_325 2810-4341 181 µM 0.772826745965255 0.227114561484821 no 778 0.219812461194957 1093 774970 SGTC_2940 9060638 45.86 µM 0.772704659831767 0.22715074215362 no 779 0.21984859413293 1046 4027022 SGTC_601 0986-0029 62.9 µM 0.770784562518492 0.227720197151948 no 780 0.220417319512106 1068 24747981 SGTC_2516 gossypol 71.55 µM 0.768800267945192 0.228309534904656 no 781 0.221005944901414 1100 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2226 7298446 200 µM 0.768656310964715 0.228352323617662 no 782 0.221048683582192 1063 3283010 SGTC_3193 9111931 49.47 µM 0.766056334253702 0.229125896837525 no 783 0.221821391602697 1117 17087244 SGTC_948 3448-0295 75.3 µM 0.764138074413409 0.229697579282115 no 784 0.222392482426556 1110 678569 SGTC_1550 gossypolone 36.6 µM 0.760943722285413 0.23065133492171 no 785 0.223345341053565 1116 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3317 9138495 8.753 µM 0.760342986609722 0.230830946804866 no 786 0.223524796565783 1123 17020139 SGTC_2174 5790901 200 µM 0.760018401825739 0.230928025781615 no 787 0.223621792678129 1091 786020 SGTC_2359 9039622 200 µM 0.759236119789676 0.231162089544366 no 788 0.223855661414849 1102 6463596 SGTC_3011 9081274 71.4286 µM 0.757657691275812 0.231634768173896 no 789 0.224327966709897 1115 6625322 SGTC_2181 6316240 54.2555 µM 0.757566815073226 0.231661998490589 no 790 0.224355176353991 1075 12779990 SGTC_1969 st069479 40.1 µM 0.757094706457603 0.231803490709049 no 791 0.224496562617044 1062 3895485 SGTC_2025 5147754 141 µM 0.756971227518857 0.231840505618946 no 792 0.224533550213112 1097 315777 YLR208W SEC13 SGTC_1180 1193-0155 285 µM 0.756019682183982 0.232125857916386 no 793 0.224818697571992 1089 2921347 SGTC_1169 aniline yellow 25.8 µM 0.755911456532768 0.232158325329612 no 794 0.224851142298093 1086 6051 A DNA damaging agent. SGTC_445 e6 berbamine 66 µM 0.755798521368176 0.232192208279263 no 795 0.224885001708835 1150 6610268 A calcium/calmodulin antagonist. SGTC_2203 7227154 166.4 µM 0.755766659458171 0.232201768027157 no 796 0.224894554840821 1108 896304 SGTC_355 1311-2252 105 µM 0.755705718649742 0.232220053126944 no 797 0.224912827317343 1083 5338538 SGTC_1182 1222-0449 220 µM 0.755641713509384 0.232239258532669 no 798 0.224932019508435 1065 658318 SGTC_1695 st026914 34.495 µM 0.755234102118838 0.23236158728989 no 799 0.225054265152201 1061 3289191 SGTC_19 0279-0214 38.434 µM 0.75324310567645 0.232959622529715 no 800 0.225651920339033 1197 3566274 YBR002C RER2 SGTC_2565 isoliquiritigenin 100 µM 0.752694113686474 0.233124673389808 no 801 0.225816873976434 1031 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_41 0478-0632 82.643 µM 0.752523412248078 0.233176006892148 no 802 0.225868177916182 1146 3750424 SGTC_1840 st055363 71 µM 0.750692702498202 0.233726934026982 no 803 0.226418807918908 1071 676033 SGTC_1804 st050076 49.1 µM 0.74851463253166 0.234383333324004 no 804 0.227074901201702 1096 3895976 SGTC_3013 9080133 71.4286 µM 0.74772079857824 0.234622822415804 no 805 0.22731429160594 1173 17050193 SGTC_991 3996-0057 64.7 µM 0.74755245582652 0.234673626560378 no 806 0.227365075704899 1061 715343 SGTC_964 1287-0107 19.4 µM 0.746911949064009 0.23486698063306 no 807 0.227558356331469 1121 51516812 YPR165W RHO1 SGTC_1176 0848-0131 83.3 µM 0.744609012298254 0.235562910485458 no 808 0.228254059066007 1187 6769040 SGTC_2800 7887935 81.82 µM 0.744330964607305 0.235647011268347 no 809 0.228338136342371 1080 2961002 SGTC_561 1550-0330 72.9 µM 0.743254820440131 0.235972667461748 no 810 0.228663709511997 1093 6812934 SGTC_2016 5121758 140 µM 0.743184289218746 0.235994019847281 no 811 0.228685056897678 1163 2795203 SGTC_2445 5742597 35.57 µM 0.742449660811503 0.236216482075176 no 812 0.228907470279477 1064 1774255 SGTC_2827 7993847 71.43 µM 0.741671254240554 0.236452327298347 no 813 0.229143270180083 1061 2985692 SGTC_1150 3909-7983 10.9 µM 0.741252325946779 0.236579309756937 no 814 0.229270230987919 1124 23965914 SGTC_2065 5221596 34.26 µM 0.74041047295508 0.236834599458456 no 815 0.229525482983992 1094 788581 SGTC_597 k018-0003 82.8 µM 0.73968006804784 0.237056215487775 no 816 0.229747072579783 1217 6786234 SGTC_485 niflumic acid 177 µM 0.739330960145882 0.2371621804072 no 817 0.229853026926595 1099 4488 A COX2 inhibitor. SGTC_1188 1403-0014 4.57 µM 0.738157181081879 0.23751864899118 no 818 0.230209469745661 1162 9614867 SGTC_2737 bleomycin 30.5 nM 0.738056259726619 0.237549311832299 no 819 0.230240131075738 1176 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2260 7964312 200 µM 0.737584913774448 0.237692549196266 no 820 0.230383362859498 1107 231951 SGTC_1382 3002-2117 298 µM 0.737150809946198 0.237824510952532 no 821 0.23051532162912 1175 1497314 SGTC_694 1315-0438 43.2 µM 0.734695442020044 0.238571665759399 no 822 0.231262498420054 1049 6793154 SGTC_2362 9071156 126 µM 0.734669984419235 0.238579419089368 no 823 0.231270252324199 1114 653133 SGTC_2894 9048625 32.47 µM 0.733230780285186 0.239017965225167 no 824 0.231708842483975 1172 4092861 SGTC_1967 st070177 51.4 µM 0.733219101646007 0.239021525675663 no 825 0.231712403384686 1152 5729214 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.730588924496186 0.239824122271854 no 826 0.232515139527787 1082 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_299 1273-0059 1.44 µM 0.729778252262525 0.240071794381331 no 827 0.232762869972663 1101 2848077 SGTC_768 0384-0033 77.3 µM 0.724915695199128 0.241560298507416 no 828 0.234251875754885 1126 3965305 YMR134W ERG29 SGTC_2312 7706453 155.7 µM 0.722610724176525 0.242267632833406 no 829 0.234959538869297 1151 976098 SGTC_2601 securinine 100 µM 0.722460653917038 0.242313724296802 no 830 0.235005653770597 1138 442872 A GABA receptor antagonist. SGTC_2111 5486399 200 µM 0.722429475436101 0.242323300819716 no 831 0.235015235194122 1183 689674 SGTC_1373 2887-0003 58.5 µM 0.722404751866889 0.242330894851423 no 832 0.235022833119485 1125 776948 SGTC_115 0527-0192 112.043 µM 0.721919006854613 0.242480121267912 no 833 0.235172137402614 1181 4233931 SGTC_3113 9123498 49.47 µM 0.721363832017671 0.242650738257997 no 834 0.235342846577537 1206 8897275 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.720663582956874 0.242866032293438 no 835 0.235558261738347 1103 279621 SGTC_1995 st072814 61.1 µM 0.720065502946053 0.243049995906263 no 836 0.235742333090267 1125 5769371 SGTC_118 0083-0097 135.343 µM 0.71947782663132 0.243230832827314 no 837 0.235923279723961 1239 5207356 SGTC_2152 5568786 200 µM 0.718903653301813 0.243407584897496 no 838 0.236100142670351 1144 5399883 SGTC_3009 9080819 71.4286 µM 0.718290060542284 0.243596548430172 no 839 0.236289228717584 1179 17027216 SGTC_1042 0350-0096 82 µM 0.717285081887255 0.243906215186022 no 840 0.236599105124058 1142 3122515 SGTC_685 1278-0033 54.9 µM 0.717120808881876 0.243956853256327 no 841 0.2366497785254 1185 3590572 SGTC_3164 9100705 49.47 µM 0.712701088074798 0.245321383606385 no 842 0.238015371523333 1159 17174235 SGTC_2482 5981709 142.65 µM 0.711301375910712 0.245754380023796 no 843 0.238448749575493 1137 877755 SGTC_2067 5224629 34.075 µM 0.709342301074516 0.246361101845271 no 844 0.239056042012214 1176 2835000 SGTC_2236 dapsone 200 µM 0.70923458757693 0.246394483783601 no 845 0.23908945655841 1201 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_281 1672-3440 14.9 µM 0.707488560914287 0.246935940156138 no 846 0.23963145945764 1188 6833000 SGTC_3222 9128301 49.47 µM 0.70631438944579 0.247300417580493 no 847 0.239996323440674 1214 4911358 SGTC_2708 st078559 56 µM 0.705924432540514 0.247421528642069 no 848 0.240117566269705 1103 17250902 SGTC_1725 st036284 20.55 µM 0.705144618933775 0.247663814688424 no 849 0.240360120883361 1201 707914 SGTC_3284 9108171 64.8615 µM 0.704403351618324 0.247894241924447 no 850 0.240590809675021 1125 8687505 SGTC_1270 0831-1170 17.3 µM 0.703829805295778 0.248072610609753 no 851 0.240769384926058 1180 6764716 SGTC_520 3584-0023 682 µM 0.70229674879806 0.248549715796098 no 852 0.241247060202691 1129 1340790 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.701197192326558 0.248892211505619 no 853 0.241589980896015 1223 6708784 An antioxidant flavonoid SGTC_3253 9135987 49.47 µM 0.699060507503342 0.249558475187847 no 854 0.242257108891902 1181 4182430 SGTC_3046 9092212 49.47 µM 0.699047188539361 0.249562631293183 no 855 0.242261270544309 1207 25236637 SGTC_856 0433-0016 11.3 µM 0.698670320805639 0.24968024591959 no 856 0.242379042947003 1200 3911780 SGTC_169 k015-0017 16.025 µM 0.698051000048185 0.249873590329464 no 857 0.242572650072145 1221 1840002 SGTC_251 melphalan 456.522 µM 0.697738091891289 0.249971306663373 no 858 0.242670500766026 1254 460612 A DNA alkylator. SGTC_2594 a-mangostin 100 µM 0.697371966555648 0.250085667631955 no 859 0.242785020330414 1197 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2878 9043973 25.97 µM 0.695657835349861 0.250621453525647 no 860 0.243321568608874 1209 6465167 SGTC_1882 5615643 20 µM 0.695540543380841 0.250658137683412 no 861 0.243358306131161 1145 2253075 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.695261683911273 0.250745365001921 no 862 0.243445660938664 1196 616764 SGTC_1787 fluconazole 80 µM 0.694612117720639 0.25094861179588 no 863 0.243649208063694 1127 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1108 betulinic acid 729.144 nM 0.69381776187193 0.251197281179696 no 864 0.243898251119122 1222 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1885 st057546 99.9 µM 0.692964809341058 0.251464439001366 no 865 0.244165818014138 1227 702008 SGTC_352 k048-0007 5.11 µM 0.692158637398704 0.251717082383676 no 866 0.244418855496683 1186 6811911 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.690481516211765 0.25224309866288 no 867 0.244945714888713 1225 165506 SGTC_2114 5491910 81.25 µM 0.69038369671129 0.252273796883292 no 868 0.244976463253743 1230 2849228 SGTC_3187 9109394 49.47 µM 0.690251812459756 0.252315188597714 no 869 0.245017922744362 1160 17098090 SGTC_1742 st038235 28.8875 µM 0.690126338997293 0.252354571616961 no 870 0.24505737042559 1175 564103 YBR002C RER2 SGTC_1830 st055982 50.3 µM 0.689785090048472 0.252461697617777 no 871 0.245164673176446 1161 455313 An antimicrobial agent. SGTC_91 0417-1751 58.384 µM 0.689422223851813 0.252575636061264 no 872 0.245278800993683 1295 6795624 SGTC_3319 9138450 16.7555 µM 0.68917655123272 0.252652791595499 no 873 0.245356085575414 1165 2029690 SGTC_3169 9102970 49.47 µM 0.688679684901304 0.252808874543098 no 874 0.245512431579254 1264 17027839 SGTC_629 3448-6466 76.7 µM 0.688244871565771 0.252945506131144 no 875 0.245649295634219 1211 573744 SGTC_2695 st077686 51.995 µM 0.687988631858439 0.253026042643123 no 876 0.245729970130693 1196 2876092 SGTC_512 prima-1 270 µM 0.687244113143734 0.253260122483723 no 877 0.245964455057038 1201 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1137 ixabepilone 100 µM 0.686586054649715 0.253467113620488 no 878 0.246171809396585 1220 154225 A novel microtubule stabilizer. SGTC_513 4245-1575 41.7 µM 0.686403635841083 0.253524508867854 no 879 0.246229306183679 1198 719745 SGTC_3181 9108277 49.47 µM 0.68545966247976 0.253821624496396 no 880 0.246526953201445 1185 17097298 SGTC_1094 duloxetine 25.4 µM 0.685059207992924 0.253947722749112 no 881 0.24665327989225 1211 60834 A selective serotonin reuptake inhibitor. SGTC_955 1216-0110 33 µM 0.683495635466284 0.254440387330182 no 882 0.247146853588156 1187 3619719 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.682901744180852 0.254627647135821 no 883 0.247334465872409 1247 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1254 0550-0035 264 µM 0.682683239570481 0.254696561963728 no 884 0.24740351137787 1247 15121435 SGTC_745 0469-0705 296 µM 0.68186519576203 0.254954653972626 no 885 0.247662097367881 1297 3486736 SGTC_1916 st067606 49.2 µM 0.680866725925241 0.255269855569957 no 886 0.247977912053017 1237 19590279 SGTC_2118 5526350 200 µM 0.679945913114179 0.255560722507683 no 887 0.248269354292911 1214 743594 SGTC_482 fipronil 114 µM 0.679202759113858 0.255795596648003 no 888 0.24850469966572 1240 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_23 0213-0011 39.996 µM 0.678022836703632 0.256168742981692 no 889 0.248878606900765 1245 627608 SGTC_3341 9147222 25.867 µM 0.677399830893057 0.256365880828806 no 890 0.249076152803764 1200 1939759 SGTC_1662 st014054 52 µM 0.675381649393034 0.257005036872531 no 891 0.249716660601342 1233 2838777 SGTC_3353 9151644 39.2805 µM 0.673510855527739 0.257598254884648 no 892 0.250311172458228 1233 4909158 SGTC_592 k241-0073 46.5 µM 0.672427786136547 0.257942014686691 no 893 0.250655699266291 1243 4230158 SGTC_654 1124-0271 80.9 µM 0.672073344380887 0.258054564061357 no 894 0.2507685025089 1237 5403748 SGTC_2416 tofa 880 nM 0.671861844561473 0.258121735809023 no 895 0.250835826414724 1169 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1610 st001799 48.1 µM 0.669855582755638 0.258759369516811 no 896 0.251474928461413 1173 621897 SGTC_931 2812-0076 566 µM 0.66974047221855 0.258795978866172 no 897 0.251511623429138 1260 3450959 SGTC_1419 3993-2473 62.6 µM 0.668871979822142 0.25907227750278 no 898 0.251788572843018 1270 704026 SGTC_533 1222-0222 6.71 µM 0.66700741179093 0.259665978430742 no 899 0.252383699561164 1299 3982874 SGTC_2713 st079149 53.4 µM 0.666961824559117 0.259680502744903 no 900 0.252398259224202 1259 3103253 SGTC_2975 9084847 53.72 µM 0.666437768830699 0.25984749956635 no 901 0.252565664082813 1258 27211724 SGTC_3140 9094243 49.47 µM 0.665749089450852 0.260067039961004 no 902 0.252785745388425 1268 19291112 SGTC_1939 st074455 53.6 µM 0.665066746582265 0.260284654652209 no 903 0.253003901273997 1268 1644229 SGTC_707 0865-0008 204 µM 0.663684895094461 0.260725645808183 no 904 0.253446004475973 1257 723043 SGTC_2744 captopril 92.04 µM 0.663560570952838 0.260765340294864 no 905 0.253485800065921 1227 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2642 cholecalciferol 100 µM 0.663220781753101 0.26087384480195 no 906 0.25359458178465 1231 9821465 A vitamin D precursor, similar to steriods. SGTC_869 0564-0080 44.1 µM 0.663114944766756 0.260907646351643 no 907 0.253628469945124 1234 6843321 SGTC_1729 st035615 45.989 µM 0.661597378792168 0.26139256459405 no 908 0.254114643937211 1229 17385451 SGTC_2839 9003951 25.97 µM 0.660946866658483 0.261600568827322 no 909 0.254323194391167 1240 2990634 SGTC_2265 7929201 200 µM 0.660765804834982 0.261658479284639 no 910 0.254381257729622 1248 1265108 SGTC_2883 9059145 45.46 µM 0.660053134712159 0.261886482184537 no 911 0.25460986596443 1238 16476510 SGTC_2365 9042475 200 µM 0.658905778122378 0.262253767255082 no 912 0.254978137604039 1276 6464479 SGTC_824 1304-0008 100 µM 0.657835489444213 0.262596619520986 no 913 0.255321923537694 1261 768245 SGTC_1865 st057639 52.2 µM 0.657818494138158 0.262602065583162 no 914 0.255327384529827 1251 688818 SGTC_36 0335-0881 14.2 µM 0.657144322918168 0.262818147044645 no 915 0.255544060858913 1213 23828853 SGTC_595 3909-8003 73.7 µM 0.656554475137234 0.263007276198664 no 916 0.255733714676438 1287 699517 SGTC_86 0417-1630 471.922 µM 0.656487221202481 0.26302884495873 no 917 0.255755343507169 1288 3634867 SGTC_234 nsc-17383 10.7 µM 0.656342217626463 0.263075351593595 no 918 0.255801979831458 1281 408974 SGTC_3346 9158254 43.5805 µM 0.653718249420623 0.263917655776979 no 919 0.256646671805299 1232 17639500 SGTC_1464 k208-0027 110 µM 0.653072762660067 0.264125070062412 no 920 0.256854685374246 1317 X1464 SGTC_2831 7999036 19.48 µM 0.653071127904792 0.264125595463788 no 921 0.256855212299327 1286 2988270 SGTC_2534 helenine 20.12 µM 0.652813812125133 0.264208301980375 no 922 0.256938159027783 1277 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.652073546316274 0.264446311975928 no 923 0.257176864247236 1293 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_141 0443-0274 32.331 µM 0.649319344449882 0.265332799182306 no 924 0.258065992355113 1343 1627241 SGTC_2655 perillic acid 100 µM 0.6485461716518 0.265581929015601 no 925 0.258315878940356 1248 5702197 An apoptosis inducer. SGTC_2523 spermine 47.74 µM 0.648278202472093 0.265668301061334 no 926 0.258402514838309 1246 1103 A DNA binding polyamine. SGTC_1091 telmisartan 47.6 µM 0.645570964609283 0.266541698277872 no 927 0.259278623158175 1336 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2920 7982904 15.77 µM 0.641241692154995 0.267941400540314 no 928 0.260682832868704 1256 6456808 SGTC_1651 st011928 86.1 µM 0.640996281220207 0.268020855362565 no 929 0.260762549543074 1285 720198 SGTC_1898 st060199 18.6 µM 0.640921506161015 0.268045067069437 no 930 0.260786841169782 1285 688866 SGTC_2444 5485484 36.41 µM 0.640101388854394 0.268310688280674 no 931 0.261053343071626 1348 6790631 SGTC_2468 5987765 72.9 µM 0.639807568028799 0.268405883754294 no 932 0.261148855916739 1327 26772094 SGTC_776 4476-4378 112 µM 0.639336889924593 0.268558414884975 no 933 0.261301897485098 1277 2892008 SGTC_119 0121-0043 24.815 µM 0.637810928059129 0.2690532278231 no 934 0.26179838250537 1331 1092378 SGTC_499 genistein 192 µM 0.636359312523438 0.269524357273884 no 935 0.262271127002396 1289 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3202 9113761 49.47 µM 0.631549612322484 0.271088319195173 no 936 0.263840610391952 1357 4798415 SGTC_3128 9127691 49.47 µM 0.631406374105259 0.271134965030024 no 937 0.26388742467442 1295 41316314 SGTC_682 0kpi-0099 17 µM 0.631143094406584 0.27122071307051 no 938 0.26397348293626 1298 1714895 YML126C ERG13 SGTC_880 0833-0487 87.2 µM 0.627759608389779 0.272323888535565 no 939 0.265080714951343 1273 76075 SGTC_2693 st077581 40.7 µM 0.62575777624554 0.27297762789977 no 940 0.265736915363446 1318 25238761 SGTC_1092 toremifene 6.32 µM 0.625722314959172 0.272989215520584 no 941 0.265748546989137 1311 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2101 5377231 179.231 µM 0.624945485248922 0.27324311993791 no 942 0.266003418966974 1339 2844213 SGTC_287 k060-0039 29.6 µM 0.622872204498544 0.27392133766001 no 943 0.266684252457701 1348 5861974 SGTC_505 gw-5074 63.9 µM 0.617725367166332 0.275608574982942 no 944 0.268378193703071 1366 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2397 5161689 200 µM 0.617598562739105 0.275650208451162 no 945 0.268419996124691 1390 2259942 SGTC_1701 st028638 40.4 µM 0.61624706078359 0.276094136641314 no 946 0.268865736361853 1330 3490878 SGTC_2973 9094665 17.96 µM 0.616188779923281 0.276113288061719 no 947 0.268884966388531 1366 25237061 YIL048W NEO1 SGTC_1036 k216-0215 33.5 µM 0.612560265170673 0.277306921087644 no 948 0.270083569139013 1309 622330 SGTC_2643 anethole 100 µM 0.609065448744829 0.278458953408271 no 949 0.271240529079677 1310 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2070 5230947 200 µM 0.609029690834919 0.27847075269739 no 950 0.271252379501887 1378 2835538 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.608431415219341 0.278668206036738 no 951 0.27145069051224 1379 688788 SGTC_2702 st077768 96.8 µM 0.608102577472477 0.278776763821616 no 952 0.271559721436743 1260 6484119 SGTC_2213 7173844 200 µM 0.60724061376674 0.279061417829518 no 953 0.271845621473607 1307 892728 SGTC_2092 5303694 80.6725 µM 0.606877358759486 0.279181421108632 no 954 0.27196615238473 1309 1963699 SGTC_3119 9125183 49.47 µM 0.606452099494158 0.279321939698368 no 955 0.272107290568082 1213 22695334 SGTC_1026 k007-1105 30.6 µM 0.605932871136078 0.279493555112371 no 956 0.272279665264986 1335 7066794 SGTC_1699 st031318 29.054 µM 0.604696403056491 0.279902438703188 no 957 0.272690369278376 1388 5340658 SGTC_1988 st071872 53.4 µM 0.603871279420149 0.280175457428893 no 958 0.272964612451441 1353 16414116 SGTC_1777 st045864 34.765 µM 0.603401790228413 0.280330860621044 no 959 0.273120715788572 1331 4691462 SGTC_970 1315-0089 19.5 µM 0.602121955139943 0.280754704094442 no 960 0.273546480552859 1261 6811083 YLR033W RSC58 SGTC_1282 0886-0010 32.4 µM 0.601503246816432 0.280959713029013 no 961 0.273752424948637 1383 2836211 YNL267W PIK1 SGTC_1757 st041620 31.8375 µM 0.601059704363464 0.281106725280641 no 962 0.273900110487349 1321 5289815 SGTC_1741 st038134 10.228 µM 0.600639033246396 0.281246191147236 no 963 0.274040216982609 1429 1272587 SGTC_20 0481-0013 4.944 µM 0.598842924227747 0.28184203400925 no 964 0.27463881764846 1314 182045 SGTC_973 1325-0077 65.9 µM 0.596965719987813 0.282465428866345 no 965 0.275265133892571 1404 2835149 SGTC_999 SEC7.066 22.7 µM 0.595808937376688 0.282849911087312 no 966 0.27565143623267 1377 740511 YDR170C SEC7 SGTC_414 piperonyl butoxide 100 µM 0.593742329421675 0.2835374188152 no 967 0.276342233366945 1312 5794 A potent inhibitor of cytochrome P450. SGTC_123 0083-0120 66.675 µM 0.592151375768666 0.284067233428654 no 968 0.276874613255421 1291 16001701 SGTC_2145 5634607 200 µM 0.589996752942155 0.284785513526571 no 969 0.277596413211157 1324 308662 SGTC_636 0kpi-0074 126 µM 0.588409978317121 0.285315045352635 no 970 0.278128570867793 1337 616434 SGTC_825 1988-2224 89.6 µM 0.588408303456227 0.285315604527951 no 971 0.278129132829776 1365 1180859 SGTC_377 3970-0964 33.1 µM 0.587522017596503 0.285611576440443 no 972 0.278426583819123 1389 16481235 SGTC_845 0330-0138 4.51 µM 0.585701337239875 0.286220043919919 no 973 0.279038117650425 1352 9039800 SGTC_2703 st077852 53.4 µM 0.585105767919656 0.286419215452507 no 974 0.279238300377771 1360 6281836 SGTC_911 3456-4043 236 µM 0.583704786222597 0.28688799384552 no 975 0.27970947328395 1448 914281 SGTC_1527 coumarin 137 µM 0.583047524616673 0.287108043447101 no 976 0.279930653916013 1407 323 A hepatotoxic, DNA x-linker. SGTC_2054 5233173 129 µM 0.582593436021756 0.287260117878123 no 977 0.28008351261016 1404 6889 SGTC_2551 apiole 73.87 µM 0.582551015199396 0.287274326573218 no 978 0.280097794690135 1304 10659 A possible DNA adduct former. SGTC_2233 sulbentine 40.3845 µM 0.582287312662046 0.287362660206282 no 979 0.280186584966095 1347 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1859 st055998 20 µM 0.582258582554946 0.287372284836535 no 980 0.280196259394666 1437 676301 SGTC_2115 tiliquinol 12.7705 µM 0.581796425089549 0.28752712925396 no 981 0.280351906160857 1390 71208 A bioactive hydroxyquinoline. SGTC_2944 9067346 25.62 µM 0.580544902116604 0.287946646062697 no 982 0.280773607872852 1350 6473075 SGTC_1579 chlormadinone acetate 49.4 µM 0.58006775619981 0.288106663837131 no 983 0.280934463315839 1413 45114258 A steroidal progestin. SGTC_2610 ononetin 44.17 µM 0.573892629702853 0.290181357509802 no 984 0.28302023041948 1356 259632 SGTC_197 4544-0043 41.561 µM 0.569671284544447 0.291603643831559 no 985 0.284450334891524 1381 896523 SGTC_2296 7971656 126.45 µM 0.569634270621462 0.291616129193435 no 986 0.284462889696538 1382 666570 SGTC_1860 st056228 74.6 µM 0.56767177751078 0.292278464728332 no 987 0.285128929322022 1360 688679 SGTC_1893 st059353 36.1 µM 0.566316291157602 0.292736345463694 no 988 0.285589393884603 1343 3112488 SGTC_120 rhodamine 6G 52.259 µM 0.564224296182023 0.293443670454988 no 989 0.286300747399116 1384 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.563729482358868 0.29361108779683 no 990 0.286469124829841 1386 3256 An antibiotic and ribosome inhibitor. SGTC_1157 4092-0394 27.6 µM 0.563626757797185 0.29364584958938 no 991 0.286504086286027 1496 3659885 SGTC_1493 4348-0038 111 µM 0.561982660777839 0.294202467900743 no 992 0.287063916421118 1432 800424 SGTC_818 4072-2707 53.5 µM 0.560677269807263 0.294644762232566 no 993 0.287508782647631 1335 882871 SGTC_2331 7980721 200 µM 0.560312971794379 0.294768248897214 no 994 0.28763299049144 1427 2981221 SGTC_1397 3532-0190 20.1 µM 0.5566500129893 0.296011211770806 no 995 0.288883288001382 1403 5322280 SGTC_403 arphamenine a 50 µM 0.555749508876305 0.296317150601558 no 996 0.289191053181041 1389 5487158 An arginine aminopeptidase inhibitor. SGTC_3271 9137798 49.47 µM 0.553899327795504 0.296946188870166 no 997 0.289823872594898 1400 6498326 SGTC_691 1548-0686 185 µM 0.550272771685174 0.29818094121851 no 998 0.291066148432947 1370 46495133 SGTC_162 k030-0015 37.8 µM 0.549658104194231 0.298390451801197 no 999 0.291276948876501 1499 1809920 YMR134W ERG29 SGTC_481 bay k-8644 50 µM 0.548899845580851 0.298648997953675 no 1000 0.291537092079458 1360 2303 A calcium channel antagonist. SGTC_528 3492-0019 172 µM 0.548847924672477 0.298666705337289 no 1001 0.291554909056403 1449 2869262 SGTC_1989 st071868 50.2 µM 0.548564317562536 0.298763436643263 no 1002 0.291652239529331 1460 16414057 SGTC_1884 5633444 25 µM 0.546765290017808 0.299377371399401 no 1003 0.292269996141658 1429 5724239 SGTC_2460 5552655 174.22 µM 0.545831960871991 0.299696103824048 no 1004 0.292590725699184 1377 5401989 SGTC_1957 st077035 62.4 µM 0.545805061860834 0.299705292129842 no 1005 0.292599971708833 1472 705593 SGTC_556 4058-0063 51.5 µM 0.544706024021459 0.300080816315808 no 1006 0.292977860523938 1451 6615692 SGTC_2818 7996756 12.99 µM 0.544556744758584 0.300131839138382 no 1007 0.29302920557694 1391 2241621 SGTC_3114 9122766 49.47 µM 0.544505236801648 0.300149445182253 no 1008 0.293046922862815 1364 17176985 SGTC_841 0251-0215 91.2 µM 0.543937423892418 0.30034356146049 no 1009 0.293242267429609 1448 3888614 SGTC_1690 st023502 41.2 µM 0.543128877205002 0.300620074445191 no 1010 0.293520535721711 1478 24207482 SGTC_516 3992-2719 87.3 µM 0.542433315998078 0.300858039706583 no 1011 0.293760016894878 1332 5350887 YDR037W KRS1 SGTC_1399 3562-5772 25 µM 0.541559424791615 0.301157135559995 no 1012 0.294061025033122 1377 23847490 SGTC_796 1234-0020 70.7 µM 0.540726423842413 0.301442361061179 no 1013 0.294348081342301 1376 46495034 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.538849324523232 0.302085538567516 no 1014 0.294995413042411 1371 390807 SGTC_2475 5812728 15.03 µM 0.53871749638242 0.302130731885522 no 1015 0.295040899597754 1396 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1291 0993-0025 5.79 µM 0.537633654171566 0.302502409631803 no 1016 0.295414995641751 1505 4353356 SGTC_2690 usnic acid 100 µM 0.536620052189982 0.302850185540501 no 1017 0.29576504507842 1565 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1754 st042065 16.137 µM 0.533493395560846 0.30392409537889 no 1018 0.296846040811271 1373 1126236 YIL048W NEO1 SGTC_2151 5563267 85.4165 µM 0.533182292263201 0.304031042570401 no 1019 0.296953699059303 1430 5310824 SGTC_1506 4226-2149 212 µM 0.532643964972186 0.304216141594596 no 1020 0.297140031050135 1483 991114 SGTC_997 3996-0078 137 µM 0.531852359315725 0.30448841925925 no 1021 0.297414127692713 1446 735687 SGTC_3142 9086498 49.47 µM 0.531288393005373 0.304682465085647 no 1022 0.297609473711457 1385 25236367 SGTC_3121 9125696 49.47 µM 0.531285526464497 0.304683451526665 no 1023 0.297610466770242 1485 1235365 SGTC_3241 9133421 49.47 µM 0.531010364942538 0.304778147388841 no 1024 0.297705798306568 1444 17018221 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.529270241385735 0.305377307453066 no 1025 0.298308998058181 1417 16486 A toxic proline analog. SGTC_1658 st012944 20 µM 0.528893384702985 0.305507135690117 no 1026 0.298439705641977 1408 24207260 SGTC_2449 5812982 45.77 µM 0.527612938812042 0.305948435744981 no 1027 0.298884005355271 1436 776185 SGTC_1959 st077091 55.8 µM 0.527255176865277 0.30607178723262 no 1028 0.299008198246616 1438 821356 YKL052C ASK1 SGTC_1055 3448-0672 86 µM 0.526966586137254 0.306171305445003 no 1029 0.29910839622794 1430 748378 SGTC_1803 st050068 52.4 µM 0.525663673803061 0.306620782374977 no 1030 0.299560953762169 1510 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1960 st011366 51.8 µM 0.525496856724498 0.30667835173251 no 1031 0.299618918915914 1439 3972846 SGTC_2112 5488546 200 µM 0.524356527525098 0.307072012378019 no 1032 0.300015293499617 1406 600757 SGTC_1463 k081-0032 34.1 µM 0.522716996943846 0.307638395509359 no 1033 0.300585604178884 1345 977755 SGTC_2200 6600604 21.907 µM 0.52135572671688 0.308109001070961 no 1034 0.301059493579454 1404 2904777 SGTC_381 3461-2219 42.7 µM 0.521014443301467 0.308227035889709 no 1035 0.301178354940318 1518 2883159 SGTC_1383 3049-0032 20.7 µM 0.520664922286824 0.308347940286387 no 1036 0.301300107180677 1535 712864 SGTC_1450 4112-4260 37.6 µM 0.520072347538614 0.308552968001203 no 1037 0.301506575445716 1484 1633175 SGTC_608 k048-0125 159 µM 0.519665079428218 0.308693915228497 no 1038 0.301648515020677 1484 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2133 5320837 200 µM 0.518886128389339 0.308963572873752 no 1039 0.301920075823175 1500 2841355 SGTC_2835 9006588 71.43 µM 0.518586538067658 0.309067312626332 no 1040 0.302024549351238 1445 2345538 SGTC_2958 9077254 16.72 µM 0.518321597585387 0.309159066797153 no 1041 0.302116953267357 1456 16457351 SGTC_1299 1079-1439 3.74 µM 0.517775550770198 0.309348211243752 no 1042 0.302307439326069 1405 323161 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.515630119406584 0.310091853324339 no 1043 0.303056384910097 1427 23665772 A membrane-active detergent. SGTC_2061 5245884 80.95 µM 0.514942610894693 0.310330319799544 no 1044 0.303296561788123 1436 573863 SGTC_2996 9066192 71.4286 µM 0.514837835936865 0.310366668632053 no 1045 0.303333171746371 1397 6472854 SGTC_613 3914-0030 117 µM 0.513821333283964 0.310719412794974 no 1046 0.303688455656693 1381 1145395 SGTC_3092 9117248 49.47 µM 0.51262568930811 0.311134544898969 no 1047 0.304106589862613 1546 17141857 SGTC_2020 4017018 200 µM 0.511725189899816 0.311447360430667 no 1048 0.304421676962737 1458 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_622 1348-1566 26.3 µM 0.511677474485645 0.311463939614482 no 1049 0.304438376764251 1540 7340407 SGTC_2576 guaiol 23.12 µM 0.509384761706173 0.312261014948471 no 1050 0.3052412776761 1544 227829 SGTC_2903 5923464 63.88 µM 0.50883431427777 0.312452512355062 no 1051 0.305434182446652 1482 2876576 SGTC_171 k064-0041 9.68 µM 0.508812039806725 0.312460262578645 no 1052 0.3054419896919 1402 53325 SGTC_3239 9133757 49.47 µM 0.508133603223466 0.312696358875014 no 1053 0.305679825405489 1526 17036923 SGTC_846 0335-0850 148 µM 0.507983610748241 0.312748566716756 no 1054 0.305732418499561 1457 6819598 SGTC_2667 digitoxin 100 µM 0.507970237152807 0.312753221843054 no 1055 0.305737107987814 1470 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1510 1123-0200 71.5 µM 0.507245118214314 0.313005668385512 no 1056 0.305991420625662 1581 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3001 9076041 71.4286 µM 0.506990752311916 0.313094245388898 no 1057 0.306080653628283 1454 16004211 SGTC_2807 7945238 51.95 µM 0.506509030356182 0.313262023400917 no 1058 0.30624967595648 1517 17148797 SGTC_1985 st071382 65.5 µM 0.506393161073384 0.313302385059313 no 1059 0.306290337297684 1468 6123237 SGTC_356 1634-0012 32.5 µM 0.505306095060761 0.313681160168526 no 1060 0.306671931261558 1506 735457 SGTC_453 enantio-paf c16 10 µM 0.503163038375588 0.314428457814475 no 1061 0.307424824564193 1458 13871343 A lipid and platelet activating factor SGTC_3024 9090631 49.47 µM 0.503084633719315 0.314455812471548 no 1062 0.3074523849098 1475 25236383 SGTC_1512 0259-0544 12.2 µM 0.503067592380189 0.314461758171425 no 1063 0.307458375325355 1536 18476 SGTC_2624 nerol 100 µM 0.502676051430323 0.314598379525303 no 1064 0.30759602495413 1547 637566 A natural product oil. SGTC_3104 9120930 49.47 µM 0.501489699526617 0.315012491181488 no 1065 0.308013262647012 1470 17014836 SGTC_2320 7373003 200 µM 0.501293794139039 0.31508089691422 no 1066 0.308082186095738 1403 5415828 SGTC_366 0181-0206 4.31 µM 0.501020523077219 0.315176327585089 no 1067 0.308178339648223 1628 274874 SGTC_2902 5787006 60.46 µM 0.500704298113877 0.315286773848681 no 1068 0.308289623455009 1457 591003 SGTC_3257 9139206 32.98 µM 0.499052111335162 0.315864092899667 no 1069 0.308871336503063 1497 4910041 SGTC_786 4544-0069 423 µM 0.497819393420315 0.31629513098756 no 1070 0.30930567275886 1541 748821 YLR208W SEC13 SGTC_805 3852-0218 479 µM 0.493070087822995 0.317958126421096 no 1071 0.310981532697066 1442 6615355 SGTC_740 k014-0057 261 µM 0.492892616189268 0.318020340572329 no 1072 0.311044232414767 1595 4012779 SGTC_2863 9028737 58.44 µM 0.488676793839898 0.319499738828398 no 1073 0.31253526779454 1590 6460917 SGTC_2135 5326629 150.42 µM 0.486727168878119 0.320184867401902 no 1074 0.313225844491044 1459 5020077 SGTC_1769 st044406 64.4 µM 0.484652548972923 0.320914594996863 no 1075 0.313961415623113 1507 670903 SGTC_2986 9022445 71.43 µM 0.483462290723466 0.321333569641663 no 1076 0.314383764294182 1607 6459286 SGTC_427 1354-0053 47.3 µM 0.482579548213205 0.321644444717853 no 1077 0.314697151776571 1579 6813657 SGTC_1309 pyrazolanthrone 13.4 µM 0.480395105624416 0.322414275717909 no 1078 0.315473236937751 1604 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1617 st002906 78 µM 0.480186742459237 0.322487745952843 no 1079 0.315547306473422 1490 5150859 SGTC_968 1309-0633 340 µM 0.479826301175476 0.322614856310263 no 1080 0.315675454672714 1524 3761976 SGTC_2711 st079103 59.1 µM 0.476787298137198 0.323687390096227 no 1081 0.316756795725531 1613 54693780 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.475092943822238 0.324286003720556 no 1082 0.317360363832218 1541 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2179 6298986 200 µM 0.474217368285589 0.324595521854949 no 1083 0.317672454613073 1626 738374 SGTC_2734 clemastine 41.6 µM 0.473464242758463 0.324861850565072 no 1084 0.317941002919662 1532 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1097 itavastatin 7.23 µM 0.473055584229343 0.325006402470616 no 1085 0.318086761822126 1529 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_332 4112-0506 40.9 µM 0.472816982110656 0.325090813702599 no 1086 0.318171878627179 1554 2790355 SGTC_747 3448-8087 38.7 µM 0.471886502909298 0.32542007881538 no 1087 0.318503901240219 1498 5168703 SGTC_2315 7733312 200 µM 0.471305220460971 0.325625844203743 no 1088 0.318711394095748 1488 726316 SGTC_157 1348-1695 65.819 µM 0.470920849241391 0.325761935123883 no 1089 0.318848629333806 1488 5380510 SGTC_692 k241-0027 77.8 µM 0.470158106794068 0.32603206135015 no 1090 0.319121031130318 1612 3600480 SGTC_399 oxolinic acid 75 µM 0.469521015011932 0.326257758233908 no 1091 0.319348633605493 1491 4628 A DNA gyrase inhibitor. SGTC_566 0958-0068 16.5 µM 0.469003590661198 0.326441108431452 no 1092 0.319533534732937 1546 6815365 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.468873152302332 0.326487336106455 no 1093 0.319580153847344 1501 688803 SGTC_871 0574-0004 149 µM 0.468693461096831 0.326551023475478 no 1094 0.319644380766488 1533 9551173 SGTC_935 2996-0153 430 µM 0.467388967980628 0.327013522201284 no 1095 0.32011080703242 1599 23738523 SGTC_559 1550-0661 158 µM 0.466236349085821 0.327422396243807 no 1096 0.320523166856038 1592 5830875 SGTC_2809 7964133 12.99 µM 0.464120347016153 0.32817355468086 no 1097 0.321280762387777 1551 1253665 SGTC_2904 7225135 42.03 µM 0.463557362017476 0.328373525662605 no 1098 0.321482454270008 1568 4446116 SGTC_3025 9087895 49.47 µM 0.463099213214674 0.328536295366552 no 1099 0.32164662697241 1600 17173641 SGTC_2867 9039098 71.43 µM 0.462848122669449 0.328625515853692 no 1100 0.321736617351728 1501 6463460 SGTC_250 brefeldin a 552.239 µM 0.460669856077895 0.329399933093622 no 1101 0.3225177424602 1474 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1968 st069590 43.6 µM 0.458421035859074 0.330200201967283 no 1102 0.323324990759306 1610 6384066 SGTC_1638 st008370 60.6 µM 0.458042090741879 0.330335130638178 no 1103 0.323461100947411 1496 24207134 SGTC_504 lovastatin 124 µM 0.458001998298514 0.330349407400243 no 1104 0.323475502805639 1495 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2486 5283202 22.39 µM 0.457540680762521 0.330513698531959 no 1105 0.32364123459655 1499 1377751 SGTC_2859 9028643 45.46 µM 0.456054122815248 0.331043335346563 no 1106 0.324175529577286 1562 17151580 SGTC_1540 guanosine 70.6 µM 0.454425533575259 0.33162396394336 no 1107 0.324761288992304 1560 6802 Guanosine is a purine nucleoside SGTC_185 k048-0037 25.491 µM 0.453938065777087 0.331797835926388 no 1108 0.324936702333498 1621 6827589 SGTC_2989 9073649 71.4286 µM 0.4536421791178 0.331903391650755 no 1109 0.325043194901582 1608 21367202 SGTC_284 0988-0104 32.6 µM 0.4535174479211 0.331947892727628 no 1110 0.325088091190451 1600 4666532 SGTC_182 3448-4371 550.524 µM 0.453307869641786 0.332022670531278 no 1111 0.325163533425416 1677 3491403 SGTC_1719 st032227 49.2 µM 0.452552602385831 0.33229220635636 no 1112 0.325435467650244 1509 3125804 SGTC_1063 disulfiram 1.84 µM 0.449944577030725 0.333223611170188 no 1113 0.326375202011847 1551 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2640 pentamidine 10.38 µM 0.448106562061384 0.333880640794167 no 1114 0.327038146209765 1648 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_717 1532-0246 73.2 µM 0.446959077371431 0.334291087186054 no 1115 0.327452303657604 1536 9561992 SGTC_2324 6149169 200 µM 0.446776001013148 0.33435659052886 no 1116 0.327518400401877 1603 2888231 SGTC_562 3772-2733 112 µM 0.446454547298722 0.334471616450334 no 1117 0.32763446912165 1591 2876874 YIL048W NEO1 SGTC_2841 9004761 38.96 µM 0.44544590184122 0.334832641333702 no 1118 0.327998773313293 1464 2991039 SGTC_2402 5553605 200 µM 0.444841836231979 0.335048927923065 no 1119 0.328217029106689 1632 6758546 SGTC_2627 acetyl isogambogic acid 100 µM 0.443596703675866 0.335494922036764 no 1120 0.328667094688296 1490 6857789 A caspase activator and apoptosis inducer. SGTC_2757 clomiphene 4.22 µM 0.443486102278028 0.335534549582072 no 1121 0.328707084699619 1709 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2446 5162541 200 µM 0.442406567725304 0.335921433697524 no 1122 0.329097513630465 1519 1549321 SGTC_1841 st054148 70 µM 0.442372739093551 0.335933560031477 no 1123 0.329109751249087 1510 675442 SGTC_2919 7978188 46.38 µM 0.442114944768215 0.336025975528848 no 1124 0.329203015207471 1684 2980291 SGTC_723 4182-0001 115 µM 0.441771516562796 0.336149104919575 no 1125 0.329327276013857 1535 744821 YLR208W SEC13 SGTC_1335 1486-0900 202 µM 0.441426164737381 0.336272941716041 no 1126 0.329452251846029 1549 X1335 SGTC_2773 thioridazine 9.09 µM 0.439938861594697 0.336806464078532 no 1127 0.329990694307596 1571 5452 An antipsychotic. SGTC_578 3460-0051 92 µM 0.439020358792156 0.337136111725277 no 1128 0.330323392327167 1635 2876744 SGTC_1926 methyl fluorone black 53.6 µM 0.438643597864975 0.337271366182684 no 1129 0.33045990064514 1479 72721 Reacts with homocysteine. SGTC_2997 9067075 71.4286 µM 0.43563350291455 0.338352722621649 no 1130 0.331551329516081 1622 27209819 SGTC_853 0419-0306 21 µM 0.435007761193395 0.338577683981431 no 1131 0.331778396970002 1516 762713 SGTC_2389 9091542 195.52 µM 0.434798300937612 0.338653000230962 no 1132 0.33185441915105 1553 3626624 YOL127W RPL25 SGTC_2250 alverine citrate 130 µM 0.429954135533108 0.340396626084346 no 1133 0.33361450229033 1552 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_737 1950-0117 57.9 µM 0.427109593599381 0.341422095659231 no 1134 0.334649752824297 1658 5393513 SGTC_2689 tacrolimus 100 µM 0.422283426463311 0.343164627388031 no 1135 0.336409076935478 1581 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2470 5664817 21.68 µM 0.42059317111372 0.343775701220802 no 1136 0.337026090581254 1610 2859561 SGTC_2427 5545055 42.75 µM 0.420260126170997 0.343896154345182 no 1137 0.337147717658997 1645 5372858 SGTC_2768 sulfasalazine 50.2 µM 0.419170260118388 0.344290439402381 no 1138 0.337545852635408 1735 5384001 An antioxidant and salicylic acid derivative. SGTC_3125 9127534 49.47 µM 0.417614533805788 0.34485355376912 no 1139 0.338114484411421 1570 1639235 SGTC_3213 9129884 49.47 µM 0.414531725859322 0.345970429012101 no 1140 0.33924236870057 1471 17190742 SGTC_2518 prenyletin 46.28 µM 0.414507483967027 0.345979216972667 no 1141 0.339251243630485 1657 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2087 5276107 200 µM 0.413886599253248 0.346204322975355 no 1142 0.339478579216313 1588 144405 SGTC_2123 5259487 200 µM 0.413241974382399 0.34643809363971 no 1143 0.339714669028985 1709 2173474 SGTC_1215 3852-0577 11.2 µM 0.412708145533759 0.346631728853769 no 1144 0.339910228109578 1715 2884876 SGTC_264 promethazine 12.5 mM 0.411805464690843 0.346959248548113 no 1145 0.340241007828481 1590 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_106 0092-0003 11.579 µM 0.410632195424782 0.347385116753412 no 1146 0.340671126147645 1723 1072148 SGTC_1708 st033234 31.827 µM 0.409879248723404 0.347658519660622 no 1147 0.340947264222544 1690 674664 SGTC_1073 triclabendazole 3.09 µM 0.409017441000922 0.347971548419624 no 1148 0.341263430937518 1644 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2908 7930301 100 µM 0.408576397265367 0.348131785942322 no 1149 0.341425277387094 1524 2223178 SGTC_416 estradiol valerate 100 µM 0.408221933743771 0.348260587286507 no 1150 0.341555373299078 1623 13791 A steroid. SGTC_3111 9122088 49.47 µM 0.407412066967217 0.348554934084671 no 1151 0.341852682849062 1693 16876704 SGTC_848 0368-0089 85.6 µM 0.407251157635596 0.348613427590333 no 1152 0.341911765834791 1677 762535 SGTC_405 ebelactone b 50 µM 0.406797841209576 0.34877823580996 no 1153 0.342078236212495 1593 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1611 st001856 99.4 µM 0.40600750853738 0.34906563826372 no 1154 0.342368541718909 1572 647478 SGTC_1964 st076914 61 µM 0.405127524476389 0.349385744102632 no 1155 0.342691887645216 1609 24208661 SGTC_731 3966-0296 387 µM 0.404269539497821 0.349697950660181 no 1156 0.343007261123576 1625 660956 SGTC_374 0880-0231 82.3 µM 0.402884327089489 0.350202221085268 no 1157 0.343516660836813 1660 6833587 SGTC_2188 6126565 140.678 µM 0.402497530112949 0.350343077242479 no 1158 0.343658952855634 1678 874518 SGTC_1455 4262-0120 131 µM 0.400209378647314 0.35117675199208 no 1159 0.344501153715276 1707 1529587 SGTC_2992 9074591 71.4286 µM 0.399562429930024 0.351412594154798 no 1160 0.344739416478776 1627 17741321 SGTC_1340 1486-1359 257 µM 0.398461198901343 0.351814174385604 no 1161 0.345145127104239 1639 4309068 SGTC_3290 9121031 71.43 µM 0.396681506862151 0.352463514937688 no 1162 0.345801169544254 1590 17014854 SGTC_1952 st077036 64.1 µM 0.393694014235788 0.353554501522687 no 1163 0.346903480581698 1609 2937007 SGTC_1332 1480-0653 17.5 µM 0.393375263265324 0.353670975745439 no 1164 0.347021168557382 1731 5749438 SGTC_1772 st048439 82.2 µM 0.391123382300832 0.354494221269093 no 1165 0.347853018987011 1627 2927068 YDL195W SEC31 SGTC_885 0865-0106 16.8 µM 0.388051657816827 0.355618282488663 no 1166 0.348988902803095 1577 2793380 SGTC_2607 solasodine 47.35 µM 0.387599690973846 0.355783780703379 no 1167 0.349156148823362 1617 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1990 st072050 59.8 µM 0.387065755670432 0.355979328610731 no 1168 0.349353764242508 1603 17233948 SGTC_607 4491-0986 66.8 µM 0.386433351113967 0.356210988812553 no 1169 0.349587877066845 1758 698981 YDR232W HEM1 SGTC_2888 9058547 12.99 µM 0.386145350345357 0.356316505832599 no 1170 0.349694512396719 1587 16476514 SGTC_2830 7992007 71.43 µM 0.38421373813693 0.357024489194262 no 1171 0.350410018384834 1606 1952075 SGTC_344 k064-0035 6.43 µM 0.384187789781097 0.357034003263308 no 1172 0.350419633771584 1598 5088750 SGTC_2305 7443522 69.23 µM 0.382926545628155 0.357496550585513 no 1173 0.350887114112137 1727 5415886 SGTC_3183 9108214 49.47 µM 0.382593531197781 0.357618714912745 no 1174 0.351010583673975 1653 4974831 SGTC_2476 5806916 10.51 µM 0.381781180766289 0.357916781927254 no 1175 0.351311839453185 1690 2870194 SGTC_1677 st019204 53.9 µM 0.380903721880131 0.358238835826274 no 1176 0.351637345327212 1585 3945625 SGTC_63 0099-0242 26.702 µM 0.380412122485643 0.358419311751646 no 1177 0.35181975869756 1701 3898502 YLR359W ADE13 SGTC_2592 piperlongumine 83.33 µM 0.379738234423838 0.358666760866438 no 1178 0.352069867716027 1590 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3115 9123671 49.47 µM 0.379722784227804 0.35867243481546 no 1179 0.352075602703283 1714 3286988 SGTC_2842 9000675 19.48 µM 0.378841673033031 0.358996066753131 no 1180 0.352402719658075 1561 2989072 SGTC_1357 1503-1303 39.5 µM 0.378834587769514 0.358998669579363 no 1181 0.352405350540647 1643 292895 SGTC_73 0327-0325 16.231 µM 0.375987866970292 0.360044962910676 no 1182 0.353462958054833 1821 53298 SGTC_1006 4099-6547 255 µM 0.371866320013389 0.361561668077397 no 1183 0.354996191227016 1701 3146833 SGTC_2008 4012253 172 µM 0.37167527131738 0.361632025875286 no 1184 0.355067319367912 1644 603940 SGTC_3276 9139060 49.47 µM 0.371603056176032 0.361658621875291 no 1185 0.355094206649476 1699 4870619 SGTC_2890 9046729 58.44 µM 0.370972057789674 0.361891039691184 no 1186 0.355329171876426 1606 903329 SGTC_1391 3442-0225 151 µM 0.370202864989444 0.362174428031525 no 1187 0.355615671025436 1681 5227075 SGTC_3307 9126885 69.2785 µM 0.366029005046718 0.363713488008156 no 1188 0.357171716144051 1613 24824909 SGTC_1353 1498-1206 8.11 µM 0.36530332896256 0.363981297588408 no 1189 0.35744249685947 1666 6756808 SGTC_2949 9072542 2.23 µM 0.365124798787357 0.364047194049244 no 1190 0.357509125095033 1620 16457352 SGTC_3316 9136639 10.545 µM 0.364289037569181 0.364355731502264 no 1191 0.357821092534467 1743 4903665 SGTC_2678 equilin 100 µM 0.363709287077029 0.364569809291124 no 1192 0.358037553792478 1783 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1458 k015-0034 6.33 µM 0.362907598623886 0.36486590914037 no 1193 0.35833695514853 1614 3598957 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.362624998971844 0.364970305215187 no 1194 0.358442516573333 1749 5282309 SGTC_939 1165-0479 45.3 µM 0.359783077929427 0.366020704015071 no 1195 0.35950467941118 1767 1377347 SGTC_1764 st044502 93.5 µM 0.359701435665391 0.366050894594786 no 1196 0.359535209151176 1666 8407 SGTC_124 0136-0217 7.121 µM 0.359089887573236 0.36627706597602 no 1197 0.359763923177696 1793 3976905 SGTC_3310 9130229 44.1445 µM 0.358180672870316 0.366613410507608 no 1198 0.36010405493628 1777 7761258 SGTC_952 1185-0122 232 µM 0.357380210305875 0.366909609331113 no 1199 0.360403594883226 1648 678600 SGTC_3240 9133527 49.47 µM 0.356326537579082 0.367299625468724 no 1200 0.360798018868779 1684 17617455 SGTC_1983 st071813 46.9 µM 0.355464470733301 0.367618820719027 no 1201 0.361120828718649 1706 11838595 SGTC_988 1497-1057 103 µM 0.354803915731269 0.367863464611808 no 1202 0.361368247333026 1833 3533044 SGTC_1077 5-fluorocytosine 377 nM 0.353673659620749 0.368282191840334 no 1203 0.361791732459675 1712 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2232 chlorophetanol 41.5365 µM 0.353265839844614 0.368433315731979 no 1204 0.361944576243707 1793 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1874 staurosporine 7.6 µM 0.351637380649166 0.369036969043451 no 1205 0.36255511383675 1761 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2043 5101342 149 µM 0.350925181189886 0.369301075822693 no 1206 0.362822239765568 1715 678451 SGTC_3196 9111891 49.47 µM 0.350145396053424 0.369590316332425 no 1207 0.363114791747225 1689 18891510 SGTC_3194 9111903 49.47 µM 0.349731637376646 0.369743819068656 no 1208 0.36327005403645 1748 17087251 SGTC_2046 4110841 106 µM 0.349307522299942 0.369901185531555 no 1209 0.363429225867577 1800 44119630 YMR134W ERG29 SGTC_1581 himbacine 57.9 µM 0.34904713513584 0.369997812103239 no 1210 0.363526961741584 1673 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1932 st074806 40.9 µM 0.349016181562235 0.370009299151213 no 1211 0.363538580703063 1760 17251235 SGTC_2483 5729050 27.16 µM 0.34711086475886 0.370716595995511 no 1212 0.364254015739689 1835 2865180 SGTC_265 mycophenolic acid 32.932 µM 0.346648300170335 0.370888376506103 no 1213 0.364427777459558 1801 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2335 9018011 154.17 µM 0.346621901392907 0.370898180876777 no 1214 0.364437694962993 1801 6458208 SGTC_2715 st079500 56.4 µM 0.346288536423384 0.371021998128593 no 1215 0.364562941457017 1649 28246688 SGTC_2664 lyso-paf C-16 73.48 µM 0.345780811599862 0.371210601161606 no 1216 0.364753723392041 1713 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1263 0774-1208 64.8 µM 0.344782200617529 0.371581642435393 no 1217 0.365129057681226 1846 906585 SGTC_2021 4019055 173 µM 0.344664626568716 0.371625335799535 no 1218 0.365173257146366 1734 44827708 YER133W GLC7 SGTC_2765 myclobutanil 7.74 µM 0.343431481032086 0.372083702089811 no 1219 0.365636939812957 1686 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_54 0159-0055 9 µM 0.342486234003155 0.372435177887381 no 1220 0.365992500998114 1825 3319099 SGTC_433 pimozide 108 µM 0.342455343994764 0.372446665664104 no 1221 0.3660041224318 1584 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1748 st037455 53.6035 µM 0.34229074548841 0.372507880603474 no 1222 0.366066049726371 1747 580690 SGTC_371 0195-0006 7.36 µM 0.339668721471581 0.373483456710942 no 1223 0.367053009663773 1626 3928593 SGTC_3145 9085516 49.47 µM 0.338613380934799 0.373876346489378 no 1224 0.367450500498655 1664 25236195 SGTC_998 3996-0085 177 µM 0.335968375741758 0.374861623226655 no 1225 0.368447357118254 1833 715391 SGTC_3107 9121808 49.47 µM 0.333954734905897 0.375612262172993 no 1226 0.36920685795115 1831 662681 SGTC_302 1094-0063 18.9 µM 0.333730288535136 0.375695959845004 no 1227 0.369291545860883 1729 5440289 SGTC_310 1273-0058 1.06 µM 0.332696203847086 0.376081652994589 no 1228 0.369681807681393 1746 2734232 SGTC_2358 9037157 4 µM 0.332626986486809 0.376107474126954 no 1229 0.369707934995911 1756 2388925 SGTC_2941 9056145 11.23 µM 0.330460728726998 0.376915863690706 no 1230 0.370525930672435 1780 2119517 SGTC_1740 st038286 13.222 µM 0.330271639635674 0.376986452361065 no 1231 0.370597360022077 1763 716786 SGTC_797 k781-0471 270 µM 0.329557224916062 0.377253186941905 no 1232 0.370867274001915 1789 23738129 SGTC_2142 5622915 118.518 µM 0.329395890213651 0.377313431136454 no 1233 0.370928236882799 1712 5322196 SGTC_1726 st035556 14.5795 µM 0.329069510924544 0.377435313966624 no 1234 0.371051574388433 1834 5919439 SGTC_1079 idarubicin 2.36 µM 0.32900134646877 0.377460770789927 no 1235 0.371077335152522 1822 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_916 4466-0038 42 nM 0.328870902439832 0.377509488141615 no 1236 0.371126634271827 1873 5722064 YGL116W CDC20 SGTC_3098 9119039 49.47 µM 0.328573268296684 0.377620653819565 no 1237 0.371239127990211 1727 17161528 SGTC_1048 3161-0300 24.5 µM 0.327105707264958 0.378168932610292 no 1238 0.371793967644923 1703 2165101 SGTC_1891 st059073 26.2 µM 0.325168045108845 0.378893216351479 no 1239 0.372526945981654 1879 688754 SGTC_1427 4048-4900 550 nM 0.325004137509982 0.378954503348965 no 1240 0.372588970131937 1855 24132586 SGTC_985 1493-0307 8.71 µM 0.322802973149211 0.379777839124191 no 1241 0.373422230603094 1873 3278274 SGTC_3176 9106582 49.47 µM 0.32058283679134 0.380608823714761 no 1242 0.374263272953212 1839 17018027 SGTC_1290 0986-0249 10.2 µM 0.320462084325999 0.380654036523489 no 1243 0.374309034166076 1814 53329 SGTC_1046 2001-0062 216 µM 0.320437679508377 0.380663174508878 no 1244 0.374318283004424 1709 739778 SGTC_1987 st072290 61.9 µM 0.319887506365182 0.3808691955164 no 1245 0.374526804565643 1754 54697379 SGTC_2051 5263410 176 µM 0.318868588177318 0.381250834669022 no 1246 0.374913082444053 1814 227584 SGTC_459 nigericin 15.3 µM 0.315983544830613 0.382332062584561 no 1247 0.37600749903298 1770 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3165 9101544 49.47 µM 0.314806858872339 0.382773313344906 no 1248 0.376454151853261 1827 5002184 SGTC_3032 9089427 49.47 µM 0.31429731306777 0.382964437476133 no 1249 0.376647619384136 1736 17173707 SGTC_1115 galangin 695.678 nM 0.314253109118739 0.382981019157515 no 1250 0.376664404476653 1876 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1352 1496-0991 99 µM 0.313239631824256 0.383361251139857 no 1251 0.377049305261077 1730 3000039 SGTC_1400 3771-8998 51.5 µM 0.312180059427303 0.383758897039871 no 1252 0.377451842820336 1814 670767 SGTC_2275 7947463 200 µM 0.31044705229248 0.384409539336186 no 1253 0.378110508898061 1877 1225414 SGTC_769 0302-0231 76 µM 0.310253486368375 0.384482232221248 no 1254 0.378184099767981 1800 571869 YER009W NTF2 SGTC_3342 9147791 14.508 µM 0.309779067696567 0.384660415373244 no 1255 0.378364485338429 1778 1838168 SGTC_348 k064-0012 10.7 µM 0.3083707946504 0.385189480882836 no 1256 0.378900101173382 1722 5066323 SGTC_1337 1486-1011 40.3 µM 0.306324716464246 0.385958540218546 no 1257 0.379678711071142 1766 X1337 SGTC_96 0929-0093 37.281 µM 0.306144370441106 0.386026348418922 no 1258 0.379747362985946 1719 6991579 SGTC_2684 capsaicin 100 µM 0.303795309176536 0.386909887991812 no 1259 0.380641920342374 1802 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2638 epoxomicin 18 µM 0.303698869778808 0.386946173777047 no 1260 0.380678659572595 1882 9915668 A protesome inhibitor. SGTC_924 2046-0044 21.3 µM 0.301329616514081 0.387837926256384 no 1261 0.381581579546454 1711 3623589 SGTC_3034 9090421 49.47 µM 0.300925174467045 0.38799021163345 no 1262 0.381735776555146 1897 17173761 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.300222634811128 0.388254781242329 no 1263 0.382003670443019 1907 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1707 st032323 6.317 µM 0.299288816253374 0.388606528505496 no 1264 0.382359843540636 1794 3132057 YMR211W DML1 SGTC_211 3455-0679 143.504 µM 0.29818911924285 0.38902087536625 no 1265 0.382779412925564 1782 748649 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.297905418256539 0.389127789508552 no 1266 0.382887676222518 1810 7104 SGTC_2319 6033012 152.6 µM 0.297096930240379 0.389432518306884 no 1267 0.383196253968415 1725 847246 SGTC_2418 pentamidine 31.67 µM 0.296255232527895 0.38974983648485 no 1268 0.383517585702727 1770 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3134 9127454 49.47 µM 0.296222750260419 0.389762083702264 no 1269 0.383529987941729 1809 24262820 SGTC_1334 1486-0610 236 µM 0.294729507335991 0.390325218753482 no 1270 0.384100260149248 1835 3742339 SGTC_2619 obliquin 87.91 µM 0.294215105333791 0.390519264533238 no 1271 0.38429676940875 1859 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3355 9151058 44.0485 µM 0.293509973281047 0.39078530294248 no 1272 0.384566188720577 1831 17015728 SGTC_537 1334-0398 209 µM 0.293356879122153 0.390843070409835 no 1273 0.384624690842619 1927 5846986 SGTC_2459 5811157 9.22 µM 0.292541757473571 0.391150683176876 no 1274 0.384936218821522 1820 2870684 YBR192W RIM2 SGTC_542 3381-0244 89.3 µM 0.292493625647051 0.391168849424395 no 1275 0.384954616450549 1903 1112843 SGTC_1482 3346-2049 8.48 µM 0.292459115579936 0.391181874599231 no 1276 0.384967807537031 1872 3826804 SGTC_860 0443-0016 25.1 µM 0.291624401920265 0.391496958691881 no 1277 0.385286908001647 1840 5337942 SGTC_2388 9080168 200 µM 0.290434203248708 0.391946352825466 no 1278 0.385742040193522 1714 15943073 SGTC_899 1083-0020 478 µM 0.289643767749884 0.39224488446128 no 1279 0.38604438986323 1908 767123 SGTC_510 ag-490 170 µM 0.289180717842517 0.392419798600221 no 1280 0.386221543360865 1895 5328779 SGTC_2097 5376186 200 µM 0.28899015847356 0.392491787497119 no 1281 0.386294454400598 1897 742755 SGTC_3249 9135183 49.47 µM 0.288827090160347 0.392553393833685 no 1282 0.386356850114257 1841 4902779 SGTC_3321 9137793 26.8275 µM 0.288672266143642 0.392611888010821 no 1283 0.38641609398773 1798 4904192 SGTC_1851 st056236 18.9 µM 0.287911491721169 0.392899351984537 no 1284 0.386707245045796 1914 5393171 SGTC_3014 9081533 49.47 µM 0.286988534167542 0.39324817641529 no 1285 0.387060549769781 1915 21367265 SGTC_195 4234-0266 16.654 µM 0.285687644854199 0.393739982632835 no 1286 0.387558684233509 1806 2303354 SGTC_838 0109-0203 71.4 µM 0.285657792708281 0.39375127034452 no 1287 0.387570117345924 1808 759422 SGTC_3053 9095903 49.47 µM 0.285579057227505 0.39378104228093 no 1288 0.387600272818363 1868 17174018 SGTC_2945 9067681 61.76 µM 0.285409564753662 0.393845133907359 no 1289 0.387665190270042 1843 16456930 SGTC_2401 5128683 200 µM 0.2845578500782 0.394167243497028 no 1290 0.387991453713916 1721 708373 SGTC_2898 9056270 58.44 µM 0.284094617786364 0.394342463519778 no 1291 0.388168935749076 1820 19154699 SGTC_201 4262-0159 12.803 µM 0.284094565835774 0.394342483171558 no 1292 0.388168955654647 1932 1341029 SGTC_76 0433-0009 400.328 µM 0.283458116550699 0.394583258291024 no 1293 0.388412841844728 1787 2841569 SGTC_2018 5133068 143 µM 0.2828345028154 0.394819216661605 no 1294 0.388651852156933 1794 785362 SGTC_1328 1441-0025 69.2 µM 0.281300119863037 0.395399949279442 no 1295 0.389240109191624 1712 4562601 SGTC_1431 4049-0260 9.09 µM 0.277146086969524 0.396973328543808 no 1296 0.390833967486035 1877 3854841 SGTC_2420 aureobasidin a 50 nM 0.277106765588648 0.396988229948107 no 1297 0.39084906349425 1934 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1189 1431-2119 7.28 µM 0.277059665030939 0.397006079581616 no 1298 0.390867146249844 1819 3107275 SGTC_881 0833-0569 170 µM 0.276901722892946 0.397065936270824 no 1299 0.390927784814076 1736 5418700 SGTC_1818 st052136 56.3 µM 0.276859295540748 0.397082015742281 no 1300 0.390944074356157 1776 674169 SGTC_1217 1183-1422 255 µM 0.275692258834015 0.397524377537479 no 1301 0.391392220927717 1898 2849664 SGTC_518 1021-0119 62.6 µM 0.275274585831505 0.397682727308143 no 1302 0.391552644033779 1750 1097762 SGTC_821 1114-0266 29.2 µM 0.275181542215588 0.397718004653382 no 1303 0.391588383464971 1792 3123235 SGTC_1767 st044992 70.3 µM 0.274731112454565 0.397888796231715 no 1304 0.391761413141345 1763 9600693 SGTC_1491 4138-0063 26.5 µM 0.274010421818465 0.398162104596119 no 1305 0.392038306309403 1943 23883227 SGTC_1015 4130-4525 82 µM 0.273333957164015 0.398418686559201 no 1306 0.392298257377605 1770 1363237 SGTC_137 0438-0332 85.389 µM 0.273133822717208 0.398494605659602 no 1307 0.392375174034731 1872 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3129 9127257 49.47 µM 0.272109838882416 0.398883104250744 no 1308 0.392768782280344 1706 837894 SGTC_959 1222-0044 107 µM 0.272106504669394 0.398884369412181 no 1309 0.392770064094923 1979 6083612 SGTC_1407 3909-7909 12.3 µM 0.271854497769881 0.398979996073579 no 1310 0.39286694972718 1812 4411780 SGTC_2274 7947094 46.08 µM 0.269874024781144 0.399731717956484 no 1311 0.393628585588892 1859 2971028 SGTC_1849 st056239 19.2 µM 0.269477625085964 0.399882222882337 no 1312 0.393781079088396 1722 5393181 SGTC_589 1227-0070 34.1 µM 0.268195625460122 0.400369073876931 no 1313 0.394274371035391 1857 2841384 SGTC_2474 5321570 43.32 µM 0.26750530411067 0.400631293864867 no 1314 0.394540065421974 1928 2841384 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.267011357668344 0.400818947934931 no 1315 0.394730208160328 1834 521171 SGTC_2199 6590217 200 µM 0.266036639289983 0.401189318088603 no 1316 0.395105495696659 1906 703109 SGTC_787 4152-0075 138 µM 0.265692622757069 0.401320057534191 no 1317 0.395237972714246 1843 9566539 SGTC_2512 diallyl trisulfide 49.23 µM 0.264130210009993 0.401913972996712 no 1318 0.395839793005442 1915 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_663 1486-0733 13.9 µM 0.263531942644847 0.402141450715209 no 1319 0.396070303360888 1845 722445 YPR165W RHO1 SGTC_3201 9113999 49.47 µM 0.262618681852053 0.402488761504682 no 1320 0.396422249661226 1886 16649224 SGTC_3041 9091929 49.47 µM 0.262060322468548 0.402701142116836 no 1321 0.396637468046707 1899 25236887 SGTC_1010 4112-3296 15.2 µM 0.26173953561735 0.40282317134051 no 1322 0.396761128875216 1999 704384 SGTC_1806 st050005 60.3 µM 0.261498206895848 0.4029149804603 no 1323 0.396854166059232 1795 5194765 SGTC_2408 sulbentine 18.36 µM 0.260208183949557 0.403405836880172 no 1324 0.397351595884748 1882 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_861 0443-0273 110 µM 0.259698982950324 0.403599630863581 no 1325 0.397547988609651 1895 6149169 SGTC_1076 itraconazole 331 nM 0.259538031959997 0.403660891233781 no 1326 0.397610070882811 1935 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2951 9072950 58.06 µM 0.256644507544894 0.404762611987442 no 1327 0.398726606697389 1956 16488155 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.255699308533603 0.405122664325386 no 1328 0.399091514566403 1946 16725076 SGTC_3279 9140807 49.47 µM 0.255051204068242 0.405369591606265 no 1329 0.399341775744522 1871 45595718 SGTC_1836 st055642 81 µM 0.254399257952527 0.405618020558884 no 1330 0.399593562089997 1787 8571 SGTC_2175 5807670 165.306 µM 0.253884063437506 0.405814366189628 no 1331 0.399792563516494 1963 241186 SGTC_2558 carylophyllene oxide 100 µM 0.253245127624171 0.40605790374268 no 1332 0.400039397986374 1889 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1343 1487-0095 224 µM 0.252312362195511 0.406413503004604 no 1333 0.400399816768459 1982 4560101 YGL055W OLE1 SGTC_1135 dihydrocapsaicin 536.708 nM 0.250323871724065 0.407171834929283 no 1334 0.401168448519341 1728 107982 A Capsaicinoid. SGTC_2662 daunorubicin 22.37 µM 0.247568098104506 0.40822335336027 no 1335 0.402234298225392 1883 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_993 3909-8757 62.7 µM 0.247469806646833 0.408260870614158 no 1336 0.402272327862259 1863 4288324 YLR208W SEC13 SGTC_184 1494-0393 24.714 µM 0.246251444217064 0.408725981885243 no 1337 0.402743797304317 1804 3090647 SGTC_2436 5633522 8.09 µM 0.245421102132865 0.409043039653741 no 1338 0.403065195702274 1997 5724242 SGTC_2728 chlorpromazine 9.18 µM 0.244792924928158 0.409282942356647 no 1339 0.40330838618774 1912 2726 A thorazine and dopamine antagonist. SGTC_1508 1080-0625 72.9 µM 0.244013688289791 0.409580582306553 no 1340 0.403610109292936 1920 767111 SGTC_247 mechlorethamine 29.705 µM 0.241368041067738 0.41059151087242 no 1341 0.404634940062644 1905 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2310 7668677 200 µM 0.240889015301304 0.410774615200996 no 1342 0.40482056800534 1907 2197143 SGTC_3324 9138759 60.749 µM 0.239374059424662 0.411353824556019 no 1343 0.405407771478611 1912 45595710 SGTC_1839 st053978 48 µM 0.239092857314377 0.411461357171124 no 1344 0.405516790110716 2005 3788398 SGTC_2066 5222451 176 µM 0.239091196956301 0.411461992117293 no 1345 0.405517433833089 1902 2281147 SGTC_2614 arthonioic acid 13.39 µM 0.239003219754538 0.411495636268267 no 1346 0.405551543041616 1892 6710684 SGTC_2368 9071271 200 µM 0.238571574593599 0.411660714991656 no 1347 0.405718904452814 1817 27209959 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.238215721461101 0.411796819512037 no 1348 0.40585689204821 1910 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1696 st025591 34.7925 µM 0.235127922382786 0.412978265806876 no 1349 0.407054723598696 1880 2787147 SGTC_980 1473-0395 201 µM 0.234671132490336 0.413153108880472 no 1350 0.407231997516725 1841 768876 SGTC_2959 9079155 11 µM 0.234506520875134 0.413216120630175 no 1351 0.407295885696161 1906 16189457 SGTC_1052 3253-3998 198 µM 0.234389482239642 0.41326092325878 no 1352 0.407341311605461 1943 5450317 SGTC_2934 9036370 36.88 µM 0.2336902752443 0.413528604635891 no 1353 0.407612718986771 1978 6462800 SGTC_368 fentichlor 4.58 µM 0.233467698548522 0.413613823373565 no 1354 0.407699124685886 1853 7329 A pesticide. SGTC_1941 st076221 61.8 µM 0.231219854975689 0.414474690699815 no 1355 0.408572002928374 2033 2828568 SGTC_3226 9131256 49.47 µM 0.22951593196995 0.415127524264863 no 1356 0.409233969587634 1938 17178073 SGTC_257 daunorubicin 18.5 µM 0.227485187873211 0.415905880661675 no 1357 0.410023242853921 2013 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3275 9138069 49.47 µM 0.226967573411025 0.416104328091999 no 1358 0.41022447842673 1932 17617007 SGTC_1866 st057638 64 µM 0.223863891582814 0.417294690972603 no 1359 0.411431606509197 1885 688802 SGTC_2109 5483026 200 µM 0.222720027389748 0.417733591930224 no 1360 0.411876706616878 1893 759335 SGTC_330 1488-0319 80.1 µM 0.218833191976469 0.419225734295917 no 1361 0.413389995000384 1918 6846614 SGTC_2739 tacrine 100.86 µM 0.217564948451353 0.419712861080757 no 1362 0.413884048671323 1941 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_951 1171-0579 82.7 µM 0.216686255267309 0.420050435492818 no 1363 0.414226430118536 1925 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1534 6-azauridine 81.6 µM 0.213650891559081 0.421217005923727 no 1364 0.415409654925846 1932 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2537 larixol 68.93 µM 0.212855729974704 0.421522722314742 no 1365 0.41571974669995 1941 6708759 SGTC_1223 0764-0573 147 µM 0.211746607787917 0.421949226363509 no 1366 0.416152362347333 1945 1609797 SGTC_1111 tnp00062 510.699 nM 0.211720611400791 0.421959224165952 no 1367 0.416162503518363 2047 676306 SGTC_2006 4011487 200 µM 0.211188692505407 0.422163802858037 no 1368 0.41637001692462 2009 45595294 SGTC_1614 st002383 48.6 µM 0.210202390424296 0.422543195154956 no 1369 0.416754856977323 2065 1947235 SGTC_1962 st076595 64.5 µM 0.209850839327969 0.422678440668209 no 1370 0.416892046169722 1918 279619 SGTC_1825 st052143 62.6 µM 0.209792327741741 0.422700951594203 no 1371 0.41691488069616 2019 674173 SGTC_463 ikarugamyin 104 µM 0.208080099998756 0.423359801528141 no 1372 0.417583212494645 2034 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_762 1165-0429 115 µM 0.207064225669269 0.42375080233035 no 1373 0.417979850188193 2046 5967793 SGTC_822 1487-0950 154 µM 0.206821299356808 0.423844313600009 no 1374 0.418074710647977 2057 1958375 SGTC_567 1080-0542 68.4 µM 0.206098095613839 0.424122726679221 no 1375 0.418357143160189 2040 5950415 SGTC_3093 9117344 49.47 µM 0.205683575605072 0.424282322295293 no 1376 0.418519044508275 1954 24824913 SGTC_1227 3909-8010 46.6 µM 0.205109863667709 0.424503229362127 no 1377 0.418743145087731 1952 15982272 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.20509469535637 0.424509070223628 no 1378 0.418749070418229 1964 2724278 An inhibitor of dopamine biosynthesis. SGTC_767 0929-0023 86 µM 0.204760927196239 0.424637598519312 no 1379 0.418879457865167 2029 1204563 SGTC_2443 5493264 126.67 µM 0.204444992006048 0.42475926703209 no 1380 0.419002887023591 2012 5340055 SGTC_32 0928-0142 34.1 µM 0.203902097495479 0.424968355659707 no 1381 0.419215002975132 2038 2244242 SGTC_1143 3454-2408 5.08 µM 0.203612752414614 0.425079801711189 no 1382 0.419328063460763 1979 X1143 SGTC_547 1120-0019 610 nM 0.203603405420328 0.425083401960774 no 1383 0.419331715874208 1924 3676939 SGTC_268 camptothecin 39.6153 µM 0.202844634011455 0.425375684262563 no 1384 0.419628235082758 2016 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1591 genipin 88.4 µM 0.202263250149941 0.425599663812985 no 1385 0.419855464154058 2033 442424 A DNA cross-linking agent. SGTC_823 0417-1665 178 µM 0.202258496862147 0.425601495127751 no 1386 0.419857322047489 1945 3429856 SGTC_464 bw-b 70c 158 µM 0.202026158685863 0.425691010774026 no 1387 0.419948137065726 2035 5353454 SGTC_1545 lovastatin 49.4 µM 0.200571315227029 0.426251622224213 no 1388 0.420516894690753 1958 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2876 9059903 25.97 µM 0.20050423701713 0.426277473840517 no 1389 0.420543122309792 2053 6916095 SGTC_1588 farnesol 29.9 µM 0.200093569852814 0.426435749873414 no 1390 0.420703701095999 1905 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2360 9040895 200 µM 0.19978798720432 0.426553532768018 no 1391 0.420823198372795 1917 4914414 SGTC_2524 avocatin b 10.57 µM 0.199535174150427 0.426650981253973 no 1392 0.420922065756048 2040 6710748 SGTC_1275 0867-0008 21.1 µM 0.196952680740631 0.427646676100392 no 1393 0.42193228385044 1972 3422836 SGTC_2096 5468907 200 µM 0.19691484898436 0.427661265788012 no 1394 0.421947086687798 2061 759785 SGTC_1161 k007-0610 110 µM 0.196349146725725 0.427879438719609 no 1395 0.422168448224526 2086 5843850 SGTC_1134 3477-0009 42.5 µM 0.194932084877091 0.428426049971164 no 1396 0.422723057937985 2103 3973534 SGTC_983 1491-0821 12.2 µM 0.19447824168958 0.428601142548294 no 1397 0.422900715545509 2061 46495113 SGTC_1002 4049-0206 172 µM 0.193770202008473 0.428874332116828 no 1398 0.423177910060194 1924 4662749 SGTC_1296 1068-0102 11.9 µM 0.192102988339273 0.42951774312146 no 1399 0.423830767076397 2052 767053 SGTC_280 3448-3607 3.04 µM 0.191962052648931 0.429572141623358 no 1400 0.423885965086899 2070 626179 SGTC_1071 trifluoperazine 6.31 µM 0.191446532386446 0.429771134045928 no 1401 0.424087883313654 2019 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_889 0919-1524 82.7 µM 0.190046279717572 0.430311725835471 no 1402 0.424636432675243 1924 3905452 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.189443774175304 0.430544373793381 no 1403 0.424872509369689 1959 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1037 k284-1091 78.7 µM 0.189390460180411 0.430564961309062 no 1404 0.424893400421193 1957 3334711 SGTC_676 falcarinol 140 µM 0.18795827670629 0.431118077913601 no 1405 0.425454679270388 2087 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1293 1000-1278 195 µM 0.187680554257764 0.431225351423036 no 1406 0.425563537416806 2034 678847 SGTC_1934 st074720 32.6 µM 0.187592126275191 0.4312595088198 no 1407 0.425598199494687 1953 17250992 SGTC_2525 harmine 47.85 µM 0.187414026987154 0.431328305436321 no 1408 0.42566801275422 2028 5280953 A monoamine oxidase inhibitor SGTC_17 0960-0276 49.807 µM 0.187362727709613 0.431348121829801 no 1409 0.425688122024843 2045 6821114 SGTC_750 4073-0104 132 µM 0.186912309261028 0.431522121347187 no 1410 0.425864693944407 2058 22330957 SGTC_1991 st073000 8.92 µM 0.18628163748543 0.431765776195424 no 1411 0.426111953297263 2052 4301969 YIL048W NEO1 SGTC_2698 st077697 67.5 µM 0.186193653015324 0.431799770336719 no 1412 0.426146450545482 1912 3154499 SGTC_1304 1165-0502 251 µM 0.185345783975508 0.432127383312147 no 1413 0.426478914828026 2010 767425 SGTC_1047 2043-3044 82 µM 0.184591578642046 0.43241884426682 no 1414 0.426774695851165 1951 669592 SGTC_2675 theaflavin digallate 100 µM 0.184556998838399 0.432432208437161 no 1415 0.426788258199312 2011 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2283 7944793 200 µM 0.184443060507588 0.432476243105145 no 1416 0.426832945916474 1934 2970533 SGTC_1409 3909-8004 61.9 µM 0.184106947149376 0.432606148436722 no 1417 0.426964778301124 1988 2119279 SGTC_1236 0330-0013 258 µM 0.182664154528051 0.433163859712436 no 1418 0.427530771514556 1958 4617066 SGTC_1080 nisoldipine 24.4 µM 0.180858419551159 0.433862053766291 no 1419 0.4282393534721 1978 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_927 2425-1185 123 µM 0.1798382957161 0.434256579770931 no 1420 0.42863975904498 1913 730375 SGTC_3254 9136651 49.47 µM 0.17951889809526 0.434380118124865 no 1421 0.428765139913196 2019 16454030 SGTC_224 benfluorex 43.875 µM 0.179119574944702 0.434534579524087 no 1422 0.428921905992935 2078 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2730 imipramine 71.33 µM 0.178806126402634 0.434655830937778 no 1423 0.429044967319163 2097 3696 A tricyclic antidepressant. SGTC_2441 5730946 39.09 µM 0.176771292552814 0.435443115421376 no 1424 0.429844019567172 2038 1774275 SGTC_902 1120-0002 2.07 µM 0.176369046263335 0.435598776344673 no 1425 0.430002010478687 2062 3280475 SGTC_844 0330-0132 15.3 µM 0.175191668954463 0.436054454064794 no 1426 0.430464515155041 2084 2828079 SGTC_97 0535-0701 19.132 µM 0.174860127625606 0.436182785112231 no 1427 0.430594770524487 2011 2832013 YGL099W LSG1 SGTC_1422 4031-0024 15.5 µM 0.174400936420692 0.436360537208971 no 1428 0.430775189220498 2085 782427 SGTC_1234 0326-0494 15.5 µM 0.173983616778912 0.436522092047381 no 1429 0.430939168887815 2082 1547813 SGTC_508 roscovitine 141 µM 0.173711179924338 0.436627564861012 no 1430 0.431046225402082 2034 160355 A CDKinase inhibitor. SGTC_376 3970-0862 59.1 µM 0.172935534650011 0.436927877404838 no 1431 0.431351049915248 2099 3135186 SGTC_1350 1495-0454 146 µM 0.172909278124754 0.436938043982617 no 1432 0.431361369308106 2074 1069057 SGTC_2820 7989630 71.43 µM 0.172774320287422 0.436990300577438 no 1433 0.431414411450435 2131 2984098 SGTC_487 nimodipine 119 µM 0.171857650615737 0.437345270373064 no 1434 0.43177472052861 2112 4497 L-type voltage-gated calcium channels inhibitor SGTC_1462 k081-0014 26.5 µM 0.17117347128729 0.437610243843721 no 1435 0.432043683229986 2058 3270634 SGTC_1848 st056003 16.4 µM 0.170657924463463 0.437809926701871 no 1436 0.432246374401761 2157 146492 SGTC_2657 nystatin 74.44 µM 0.170555517194963 0.437849593222955 no 1437 0.432286638726364 2071 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2439 5492030 7.2 µM 0.169864237663902 0.438117370359351 no 1438 0.432558453272871 2112 5722370 SGTC_2481 5478948 45.16 µM 0.169495851091714 0.438260081814526 no 1439 0.4327033177489 1986 77792 SGTC_2520 obtusaquinone 4.71 µM 0.169123562692833 0.438404312978653 no 1440 0.432849725770516 2099 5967872 SGTC_2385 9074692 200 µM 0.168192424784439 0.43876508818762 no 1441 0.43321595010006 1960 17046906 SGTC_260 nsc-65238 3.989 µM 0.167854881524203 0.438895884017756 no 1442 0.433348722869783 2070 3246252 SGTC_226 1,3-diallylurea 8.28947 mM 0.166435031467297 0.439446139634593 no 1443 0.433907303634546 2061 74537 YKL182W FAS1 SGTC_2779 methotrexate 400 µM 0.166209736200329 0.439533462445615 no 1444 0.433995948821342 2115 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1287 0971-0001 34.6 µM 0.166166736493293 0.439550129154595 no 1445 0.434012867960985 2018 4665869 SGTC_2970 9090938 41.86 µM 0.165720633327713 0.439723045291897 no 1446 0.434188403766773 2144 17217104 SGTC_1043 0916-0009 19.3 µM 0.164994825839609 0.440004403492729 no 1447 0.434474027311858 2171 3101130 SGTC_1050 3232-1156 69.3 µM 0.164453267508549 0.440214357527105 no 1448 0.434687166460202 1970 700529 SGTC_122 0236-0016 402.397 µM 0.163461077137582 0.440599058411224 no 1449 0.435077708431644 2098 6808838 SGTC_3171 9103192 49.47 µM 0.162247811002044 0.441069552927625 no 1450 0.435555355404798 2154 13018434 SGTC_1471 k673-0312 37 µM 0.161389887565308 0.441402298749821 no 1451 0.435893165411764 2124 24099884 SGTC_1870 st057514 26.5 µM 0.16135354839338 0.441416393821638 no 1452 0.435907475107442 2028 5393161 SGTC_1213 1315-0166 115 µM 0.161167305484169 0.441488634033711 no 1453 0.435980815446661 1887 768401 SGTC_748 act1.228 77.9 µM 0.160343839885294 0.441808064549196 no 1454 0.436305113184139 2002 4421505 YNR035C ARC35 SGTC_573 3702-0553 84.7 µM 0.160077732164399 0.441911298488759 no 1455 0.436409921058754 2045 1222756 SGTC_684 1140-0066 328 µM 0.159310412324523 0.44220899493272 no 1456 0.436712158839222 2009 6813534 SGTC_1627 st003713 25.6 µM 0.158954499680876 0.442347089157982 no 1457 0.436852360975256 2000 16195070 YER133W GLC7 SGTC_2217 6934799 96.0675 µM 0.158307556193172 0.442598121378038 no 1458 0.437107227122314 2121 675606 SGTC_1489 4065-0444 182 µM 0.157969728572675 0.442729217137408 no 1459 0.437240326135848 2136 2877968 SGTC_335 4077-0256 27.6 µM 0.157398751092193 0.442950802156782 no 1460 0.437465298836396 2109 3121989 SGTC_2741 miltefosine 3.04 µM 0.156914800799854 0.443138627627747 no 1461 0.437655997504976 2060 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2451 5856223 45.7 µM 0.153458844319209 0.444480284444321 no 1462 0.439018221649929 2014 2179896 SGTC_314 1671-0008 2.74 µM 0.153421160743684 0.444494917338009 no 1463 0.439033079285108 2076 3913060 SGTC_1444 4112-3581 28 µM 0.153272078950074 0.444552807969333 no 1464 0.439091859127444 2042 2877249 SGTC_208 k072-0098 12.366 µM 0.153217372401949 0.444574051615302 no 1465 0.43911342911548 2153 5948901 SGTC_2965 9082772 38.63 µM 0.151660401453765 0.445178721066362 no 1466 0.439727395435854 2155 16459634 SGTC_569 4130-2812 160 µM 0.150923010856218 0.445465140676449 no 1467 0.440018224181029 2168 743552 SGTC_1680 diphenhydramine 100 µM 0.149691094902597 0.445943708836496 no 1468 0.440504167127162 1982 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1087 pterostilbene 9.05 µM 0.149527517108344 0.44600726060699 no 1469 0.440568698962714 2125 5281727 Similar to reservatol, lowers cholesterol. SGTC_593 1203-0218 61.7 µM 0.147905905642325 0.446637349256417 no 1470 0.441208513721748 2153 3666956 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.147593274595098 0.446758839811557 no 1471 0.441331881532498 2152 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1661 st013063 9.66 µM 0.147473876684434 0.446805239972457 no 1472 0.441378998825582 2088 721395 SGTC_1238 0333-0287 48.8 µM 0.145318500328851 0.447642982342625 no 1473 0.442229704308906 2064 7226 SGTC_3349 9149703 23.001 µM 0.144571642126538 0.447933322651037 no 1474 0.442524544136461 2146 4910494 SGTC_2880 9042983 58.44 µM 0.144320798492548 0.448030844104978 no 1475 0.442623577706286 2061 6464714 SGTC_2766 oltipraz 83.91 µM 0.143969870463455 0.448167281027665 no 1476 0.442762130811068 2137 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1147 3809-1045 12.3 µM 0.142517839636965 0.44873187949351 no 1477 0.443335494603044 2005 325925 SGTC_873 0591-4978 488 µM 0.142355337342896 0.448795072337952 no 1478 0.443399669331399 2168 3305145 SGTC_448 monastrol 171 µM 0.141523076336305 0.44911873696227 no 1479 0.443728365613855 2133 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_623 k072-0108 16.9 µM 0.140735297618664 0.449425133713023 no 1480 0.444039529566748 2071 5382803 SGTC_788 1182-0090 188 µM 0.14050952371621 0.4495129512371 no 1481 0.444128714150826 2147 5715185 SGTC_1364 1653-0028 37.6 µM 0.140178598673892 0.449641673052023 no 1482 0.44425944035951 2072 5718652 SGTC_2507 purpurin 79.67 µM 0.139637348527306 0.449852217646469 no 1483 0.444473264923515 1981 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_591 4299-0174 154 µM 0.138769201019752 0.450189953736717 no 1484 0.444816266245021 2090 5509088 SGTC_1636 st007707 68.9 µM 0.136923964365525 0.450907927098962 no 1485 0.44554544820539 2135 403051 SGTC_1755 st041960 45.185 µM 0.135854661627213 0.451324061707312 no 1486 0.445968088929558 2066 2257073 SGTC_2479 5617353 43.85 µM 0.134885619905468 0.451701224514987 no 1487 0.446351154646184 2113 2731746 SGTC_3207 9114163 49.47 µM 0.134507716139189 0.451848321086168 no 1488 0.446500554970189 2183 849233 SGTC_910 3454-3003 490 µM 0.13289884463361 0.452474637544535 no 1489 0.447136690324079 2189 820824 SGTC_58 0957-0393 9 µM 0.129461297906719 0.453813232068907 no 1490 0.448496323491508 2105 6997992 SGTC_555 4296-0685 37 µM 0.129212901498371 0.453909979144582 no 1491 0.448594593935692 2182 2908540 YHR072W ERG7 SGTC_630 4356-0227 183 µM 0.128503259888068 0.454186390100193 no 1492 0.448875359298313 2168 779312 SGTC_1907 st060210 83.7 µM 0.128344262721094 0.454248323787378 no 1493 0.448938269070908 2147 688793 SGTC_2505 galangin 7.89 µM 0.12752467343176 0.454567593546484 no 1494 0.449262573014423 2010 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1640 st009078 66.4 µM 0.126824060571747 0.454840539498362 no 1495 0.449539825960758 2173 690618 SGTC_637 1181-0519 7.26 µM 0.126678562986789 0.454897225373529 no 1496 0.449597406693265 2157 6252091 YGR060W ERG25 SGTC_3168 9103419 49.47 µM 0.126522502610919 0.454958027534057 no 1497 0.449659168834509 2191 16649256 SGTC_1439 4092-1168 46 µM 0.125975332594666 0.455171216938673 no 1498 0.449875725366234 2155 2886240 SGTC_2010 4012422 159 µM 0.12591695331025 0.455193963547924 no 1499 0.44989883134394 2131 952393 SGTC_950 1165-0508 94.1 µM 0.124737532674141 0.455653538403127 no 1500 0.450365671332186 2068 6148369 SGTC_928 2764-0428 58.7 µM 0.123749255220105 0.456038677837303 no 1501 0.450756905665539 2104 662578 SGTC_813 k007-0158 173 µM 0.123064609165704 0.456305513990115 no 1502 0.451027967999196 2162 6523916 SGTC_396 dithiazanine 1.25 µM 0.122501366199704 0.456525048893389 no 1503 0.451250982035766 2031 10578 An antihelmenthic. SGTC_659 k018-0002 107 µM 0.121428251966693 0.456943352715203 no 1504 0.451675920305418 2202 6797879 YHR007C ERG11 SGTC_3335 9143315 29.6265 µM 0.12018477845443 0.45742812284805 no 1505 0.452168387701865 2068 4899691 SGTC_367 0335-0881 7.1 µM 0.120150678457926 0.457441417681803 no 1506 0.452181893763667 2136 23828853 SGTC_918 glabranin 770.725 nM 0.120128909855299 0.457449904802974 no 1507 0.452190515731684 2115 124049 Also referred to as licorice root. SGTC_1822 st052468 42 µM 0.118499716582499 0.458085147861144 no 1508 0.452835859824466 2138 2873678 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.117454428716914 0.458492775309756 no 1509 0.453249977313288 2147 5106787 A p450 inhibitor. SGTC_2330 7979373 200 µM 0.11703924149307 0.458654696633912 no 1510 0.453414478471311 2046 1863007 SGTC_1609 st001574 46.4 µM 0.116520850717298 0.458856876549717 no 1511 0.453619881083995 2168 3960012 SGTC_3054 9094397 49.47 µM 0.116492210884645 0.458868046810261 no 1512 0.453631229442177 2140 2598354 SGTC_432 NS 1619 61.3 µM 0.115014883053037 0.459444285948772 no 1513 0.454216662680177 2073 4552 A K+/calcium channel activator. SGTC_938 3126-1755 342 µM 0.113177109402631 0.460161237586971 no 1514 0.454945071550148 2208 1777771 SGTC_1160 4092-0570 10.5 µM 0.111795925804007 0.460700149863402 no 1515 0.455492609005367 2062 4994975 SGTC_713 1488-1073 324 µM 0.110053117662518 0.461380264238083 no 1516 0.456183624455608 2225 3312542 SGTC_665 3914-0008 307 µM 0.109861370940099 0.461455098514737 no 1517 0.456259659284834 2148 1069549 SGTC_2195 6536160 144.242 µM 0.109627270559039 0.461546464287221 no 1518 0.456352491113178 2127 3834386 SGTC_99 0109-0120 622.8 µM 0.109416900397788 0.461628570251954 no 1519 0.456435914824137 2191 759414 SGTC_1645 Cervolide 78 µM 0.108021193863429 0.462173345752523 no 1520 0.456989440153496 2135 23173 A fragrance. SGTC_660 4031-1742 102 µM 0.107741237681837 0.462282627494598 no 1521 0.457100478475145 2136 6738706 SGTC_1107 amlodipine 47 µM 0.107583447708218 0.462344222543112 no 1522 0.457163063795007 2172 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2311 7694451 200 µM 0.107121064282219 0.462524724184562 no 1523 0.457346468218306 2159 2163142 SGTC_1459 k035-0031 35.7 µM 0.106071945695231 0.462934299491312 no 1524 0.457762634819479 2150 3877128 YMR208W ERG12 SGTC_617 3770-0098 35 µM 0.106004730298544 0.462960541688521 no 1525 0.457789299550074 2116 5962639 SGTC_2928 9011484 9.79 µM 0.10505034861784 0.463333168184718 no 1526 0.458167928641199 2131 2994751 SGTC_1204 4049-0315 18.3 µM 0.103237850930378 0.464040923739282 no 1527 0.458887099846681 2173 588402 SGTC_2022 5136654 200 µM 0.103080208835021 0.464102486233071 no 1528 0.458949656200859 2125 1713771 SGTC_3122 9126309 49.47 µM 0.102223187911148 0.46443718560208 no 1529 0.459289761435877 2249 17591206 SGTC_599 1935-0052 86.5 µM 0.101096033075566 0.464877420848061 no 1530 0.459737113530462 2216 9557311 SGTC_2386 9075165 157.42 µM 0.0979594166521111 0.46610272037626 no 1531 0.460982259569775 2143 16452277 SGTC_2285 7945142 200 µM 0.0972407088026734 0.466383524765611 no 1532 0.461267620130347 2154 2970608 SGTC_270 tamoxifen 5.46 µM 0.0970403204935178 0.466461820926385 no 1533 0.46134718720365 2261 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_981 1488-1094 54.9 µM 0.0969738738617354 0.466487783387158 no 1534 0.461373571140546 2207 3449522 SGTC_2930 9013230 14.89 µM 0.0966845513992356 0.466600831005047 no 1535 0.461488454272574 2199 2995857 SGTC_2041 5107442 45.335 µM 0.0963981174111637 0.466712752657152 no 1536 0.461602193625212 2224 793005 SGTC_1250 0485-0349 40.2 µM 0.0960011291352233 0.466867876810107 no 1537 0.461759837893029 2154 6842794 YDL195W SEC31 SGTC_877 0771-0151 33.1 µM 0.0959678621811519 0.466880876183741 no 1538 0.461773048492388 2144 6166523 SGTC_2666 tannic acid 100 µM 0.0957765830918429 0.466955620963086 no 1539 0.461849007915087 2242 16134267 A thiamine antagonist. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0952867317819554 0.467147042008316 no 1540 0.462043540601786 2227 6312947 SGTC_1773 st048542 73.5835 µM 0.0934347210286783 0.46787082754092 no 1541 0.462779103881973 2096 3237138 SGTC_1403 3909-7815 62.9 µM 0.0934217636685778 0.467875891792276 no 1542 0.4627842506092 2162 6615483 SGTC_2221 6807166 181.081 µM 0.0929724668042388 0.468051498075523 no 1543 0.462962717383295 2243 674925 SGTC_726 3448-4391 34.2 µM 0.0924868995810826 0.468241287504942 no 1544 0.46315559961415 2186 1356692 SGTC_2519 cryptotanshinone 88.04 µM 0.0921422959100804 0.468375984120827 no 1545 0.463292492045719 2224 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_774 k060-0086 136 µM 0.0919889584262704 0.468435920921509 no 1546 0.463353406146921 2244 5911235 SGTC_1325 1431-0015 227 µM 0.0918882680130994 0.468475279340339 no 1547 0.463393406396973 2052 1103340 SGTC_718 1130-0073 349 µM 0.0908032469221604 0.468899417782596 no 1548 0.463824465020745 2187 6740020 SGTC_2858 9025781 8.96 µM 0.0899785523424904 0.469221817341255 no 1549 0.464152129217198 2244 4894980 YPL153C RAD53 SGTC_2957 9076800 11.52 µM 0.0877132875073827 0.470107485233458 no 1550 0.465052279213508 2171 16459615 SGTC_1972 st070201 17.4 µM 0.0865342104909302 0.470568536783524 no 1551 0.465520881008886 2253 2829099 SGTC_2257 7960413 200 µM 0.0859550942897785 0.470795001636578 no 1552 0.465751057307995 2187 2974689 YIL048W NEO1 SGTC_815 1582-0027 36.9 µM 0.0855641096177675 0.470947902525538 no 1553 0.465906465082086 2191 3128206 SGTC_196 k015-0023 18.111 µM 0.0851475911664367 0.471110793523418 no 1554 0.466072027688631 2127 5211998 SGTC_189 3970-0742 2.116 µM 0.0842063369805601 0.471478914624996 no 1555 0.466446189951877 2269 2891807 SGTC_2691 st077356 60.2 µM 0.0836044724844752 0.471714314441371 no 1556 0.466685455430278 2225 2839272 SGTC_2972 9093619 59.92 µM 0.0835985780795378 0.471716619896068 no 1557 0.466687798754302 2090 25236256 SGTC_2284 7945075 39.21 µM 0.0830492339716746 0.471931486778586 no 1558 0.466906195873454 2249 1245402 SGTC_2966 9084041 48.03 µM 0.08263465137639 0.472093649331784 no 1559 0.467071023837123 2216 17741380 SGTC_565 1418-0001 44.5 µM 0.0821350280294428 0.472289081426262 no 1560 0.467269669437419 2249 2862145 SGTC_3018 9082602 49.47 µM 0.0817763342523897 0.472429391789054 no 1561 0.467412287780157 2173 17332089 SGTC_2326 6164455 177.58 µM 0.0814818412202514 0.472544591283726 no 1562 0.467529382731085 2184 2888790 SGTC_3000 9075062 71.4286 µM 0.0811706234135726 0.472666335655035 no 1563 0.467653130762656 2160 17057871 SGTC_1565 sinapyl alcohol 95.1 µM 0.0809789636129524 0.472741311755576 no 1564 0.46772934107856 2169 5280507 A phenol propionate derived from cinnamic acid. SGTC_321 4534-3890 65.3 µM 0.0809230185068563 0.472763197309096 no 1565 0.467751586937959 2278 699746 SGTC_2618 avocadyne 43.43 µM 0.0794886390444384 0.47332435004037 no 1566 0.468321983874539 2191 3015189 SGTC_2139 5578692 56.4705 µM 0.0793030936065894 0.473396942344258 no 1567 0.468395772855693 2278 650991 YMR113W FOL3 SGTC_429 1112-0049 25.5 µM 0.0784468195667091 0.473731960132167 no 1568 0.468736315811255 2090 2836170 SGTC_389 tpck 16.7 µM 0.0781271629757327 0.473857030761245 no 1569 0.468863450148681 2180 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1795 st049545 62.3 µM 0.0779914422597008 0.473910134389191 no 1570 0.468917430172799 2303 5291882 SGTC_525 k781-2675 26.7 µM 0.077853859856952 0.473963966914993 no 1571 0.468972151226346 2288 3651118 YDL195W SEC31 SGTC_1505 k297-0037 20.6 µM 0.0774848772458877 0.474108342853394 no 1572 0.469118910656142 2144 4089396 SGTC_412 gemfibrozil 100 µM 0.076747191405402 0.474396995590028 no 1573 0.469412330954474 2269 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1728 st035614 33.7865 µM 0.0765473020358994 0.474475213609694 no 1574 0.469491841377947 2137 15945546 SGTC_2044 5102272 200 µM 0.0764184185173514 0.474525647096659 no 1575 0.469543108297011 2194 592666 SGTC_2980 9014342 25.29 µM 0.0760837703320152 0.474656600382943 no 1576 0.469676226054935 2169 2996599 SGTC_2404 5161160 200 µM 0.0760707551253184 0.474661693500748 no 1577 0.469681403366981 2223 2831543 SGTC_2539 epi(13)torulosol 80 µM 0.0750157182849789 0.475074564793384 no 1578 0.470101102873871 2183 6708597 SGTC_1564 D-Arginine 115 µM 0.0740511199015996 0.475452067920596 no 1579 0.470484854541554 2173 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2465 5809242 33.21 µM 0.0739947976713564 0.475474110750451 no 1580 0.470507262385596 2280 2731748 SGTC_701 4424-0219 185 µM 0.0732383622300684 0.475770164117444 no 1581 0.470808219847916 2282 2911779 SGTC_1429 4049-0205 9.46 µM 0.0720243317462011 0.476245338723219 no 1582 0.471291272100401 2261 22774478 SGTC_1276 0871-0068 94.2 µM 0.0716658279604764 0.47638566450409 no 1583 0.471433925773107 2263 3414906 SGTC_1914 st062367 72.6 µM 0.0712227970970834 0.476559079971526 no 1584 0.471610219014077 2222 978205 SGTC_400 oxethazaine 37.5 µM 0.0702060685712435 0.476957074512917 no 1585 0.472014822112463 2181 4621 A local anesthetic. SGTC_3052 9092717 49.47 µM 0.0693307407262686 0.477299736719718 no 1586 0.472363178520267 2217 25237534 SGTC_2515 chrysin 20.77 µM 0.0683424537320536 0.477686638896869 no 1587 0.472756514958776 2261 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2220 6782180 200 µM 0.0678726965317477 0.477870550447516 no 1588 0.47294348681478 2283 833803 SGTC_864 0469-0573 172 µM 0.0678522047205534 0.477878573169244 no 1589 0.472951643061995 2136 689425 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0677606066282196 0.477914434726016 no 1590 0.47298810150476 2299 4114 Related to psoralen; DNA damaging agent. SGTC_3200 9114385 49.47 µM 0.0674737143562115 0.478026757036589 no 1591 0.473102293615228 2201 17018030 YLR208W SEC13 SGTC_346 4513-0042 7.16 µM 0.0672383341320925 0.478118912968545 no 1592 0.47319598396836 2287 2827372 SGTC_230 MPP+ 141.667 µM 0.0670249243605046 0.478202468052762 no 1593 0.473280930520886 2168 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3205 9113483 49.47 µM 0.0662892575980057 0.478490506694145 no 1594 0.473573767804378 2262 17018033 SGTC_440 fluspirilene 35.1 µM 0.0662183639574474 0.478518264569488 no 1595 0.473601988269166 2244 3396 An atypical antipsychotic. SGTC_1179 1021-1431 9.29 µM 0.0652367817444105 0.478902606402074 no 1596 0.473992737946195 2227 2840958 SGTC_38 0929-0051 58.268 µM 0.0651706172954601 0.478928514025429 no 1597 0.474019077690774 2276 1379719 SGTC_421 streptovitacin 30 mM 0.065069895727965 0.478967953146927 no 1598 0.47405917467379 2178 91467 include heat shock SGTC_1381 2324-0066 62.1 µM 0.063984801482749 0.47939285192691 no 1599 0.474491164333773 2232 10885928 SGTC_2086 5274770 176.623 µM 0.0635072773630295 0.479579847204002 no 1600 0.474681282223066 2230 689278 SGTC_282 k297-0036 65.7 µM 0.0634791246449905 0.479590871762301 no 1601 0.474692490916525 2265 5061378 SGTC_1562 morin hydrate 59.1 µM 0.0633706392595608 0.479633354607575 no 1602 0.47473568336067 2232 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3228 9131799 49.47 µM 0.0631313104118625 0.479727076531993 no 1603 0.474830970958072 2211 17015818 SGTC_2782 7736369 71.43 µM 0.0627022252426614 0.47989511042737 no 1604 0.475001812697603 2220 2950836 YOL077C BRX1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0624842975145057 0.479980454399969 no 1605 0.475088583136004 2302 756377 SGTC_1264 0783-0040 158 µM 0.0593996516329631 0.481188547493923 no 1606 0.476316895263929 2254 2855798 SGTC_1515 3460-0031 42.1 µM 0.0583827935447064 0.481586835584184 no 1607 0.476721860077213 2271 2876596 SGTC_1446 4239-0190 62 µM 0.0580705297364792 0.481709148350237 no 1608 0.476846224314881 2194 1340085 SGTC_681 1642-0006 26.6 µM 0.0574555134237923 0.481950053358232 no 1609 0.477091171339202 2309 4446530 SGTC_2383 9036125 200 µM 0.0570154166026496 0.482122445565334 no 1610 0.477266457222573 2198 79580 SGTC_295 k015-0027 31 µM 0.056997113693012 0.482129615148933 no 1611 0.477273747172326 2247 3887424 SGTC_1785 bathophenanthroline 24 µM 0.0566642559055522 0.482260002622451 no 1612 0.477406323950153 2192 72812 An iron chelator. SGTC_2242 6630449 61.2675 µM 0.0561930174585263 0.482444599984448 no 1613 0.477594021818142 2231 691249 YDR170C SEC7 SGTC_2180 6301957 200 µM 0.0555496060444549 0.482696648412944 no 1614 0.477850305510134 2303 845462 SGTC_2297 7971671 152.32 µM 0.0542520672944348 0.483204964031449 no 1615 0.478367169014899 2273 909016 SGTC_1912 st060209 90.8 µM 0.0534302828528044 0.483526915307481 no 1616 0.478694538719341 2252 688787 SGTC_903 1134-0042 114 µM 0.0521529664867216 0.484027352006045 no 1617 0.479203404601074 2290 701009 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0520120247038837 0.484082572802919 no 1618 0.479259556027811 2330 16623 A steroid. SGTC_2390 9097792 176.6 µM 0.051452419828061 0.484301828226605 no 1619 0.479482507536541 2193 4497149 SGTC_2828 7998861 71.43 µM 0.0509094532203352 0.484514569248136 no 1620 0.479698836349532 2307 2988188 SGTC_1310 1188-0297 994 nM 0.0503816709392634 0.484721365088435 no 1621 0.479909121153434 2266 1588352 SGTC_29 0299-0004 12.984 µM 0.0503123318038997 0.484748533879617 no 1622 0.47993674842892 2306 16871 A napthoquinone isolated from Swertia calycina. SGTC_1663 st014140 55.4 µM 0.0498426847926333 0.484932555072108 no 1623 0.480123875694857 2329 4207120 SGTC_2808 7946468 45.46 µM 0.049598653528326 0.485028174802151 no 1624 0.480221109820951 2275 2970879 SGTC_2471 5466956 24.79 µM 0.0482017946521523 0.485575527910922 no 1625 0.480777709963212 2241 724419 SGTC_1199 1638-0010 4.46 µM 0.0476158480098773 0.485805136718958 no 1626 0.481011200735271 2288 3111136 SGTC_1776 st049249 45.9 µM 0.0462984882969353 0.486321373817974 no 1627 0.481536172091652 2287 1822314 SGTC_2146 5545642 200 µM 0.0461310833997512 0.486386976860138 no 1628 0.481602885701275 2312 825326 SGTC_2896 9052656 71.43 µM 0.0459594610796439 0.486454233018777 no 1629 0.481671280558236 2316 6469436 SGTC_662 k832-1615 104 µM 0.0458575576532309 0.486494167593236 no 1630 0.481711891325527 2278 5878478 SGTC_2434 5670830 169.91 µM 0.0456407495289516 0.486579132214686 no 1631 0.481798294784964 2273 1549830 SGTC_1440 4100-1550 40 µM 0.0455737011340984 0.486605407836435 no 1632 0.481825015420329 2314 742806 SGTC_187 1488-2104 32.728 µM 0.0404620185831307 0.488608789905665 no 1633 0.483862393504412 2303 2852859 SGTC_2598 perillyl alcohol 100 µM 0.0393766798398664 0.489034197000433 no 1634 0.484295036139275 2301 10819 An apoptosis inducer. SGTC_2963 9082507 9 µM 0.0391306997444343 0.489130612593587 no 1635 0.484393092425005 2313 16459611 SGTC_1167 k781-0610 148 µM 0.0360648860771482 0.490332355798726 no 1636 0.485615310476964 2300 4525169 SGTC_419 nsc-638432 893 µM 0.0359448593872128 0.490379405934804 no 1637 0.485663163171332 2254 368090 SGTC_143 4032-1194 15.74 µM 0.0356749081383622 0.490485226578422 no 1638 0.48577078910875 2350 1806963 SGTC_1686 st019653 115.5 µM 0.0355770514593699 0.490523586473214 no 1639 0.485809803508805 2348 97252 SGTC_2193 5925765 200 µM 0.0349746099121074 0.490759745948823 no 1640 0.486049993419079 2321 877370 SGTC_1313 1220-0047 237 µM 0.0346815599603824 0.490874623868219 no 1641 0.48616683255051 2300 3528706 SGTC_1066 ketoconazole 628 nM 0.0345684232637574 0.490918974559087 no 1642 0.486211940514384 2326 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2751 anetholtrithion 17.25 µM 0.0335713602298142 0.491309837806498 no 1643 0.486609480307773 2327 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_454 lyso-paf C-16 6.67 µM 0.0332192833813705 0.491447859077556 no 1644 0.486749860346768 2312 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2645 abamectin 100 µM 0.0330224536404857 0.491525020778537 no 1645 0.486828340994195 2336 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2342 7990637 118.86 µM 0.0329799637719304 0.491541677807749 no 1646 0.486845282771264 2321 2033102 YER133W GLC7 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.0327616711782077 0.491627253877719 no 1647 0.48693232188105 2340 442882 SGTC_149 3970-0822 46.1 µM 0.0318464455331842 0.491986049008042 no 1648 0.487297253611889 2344 3114250 YBL034C STU1 SGTC_1018 4259-0013 28.1 µM 0.0316636821233449 0.492057698377941 no 1649 0.487370128910873 2282 6801262 SGTC_1654 st012436 41.8 µM 0.0314946588900768 0.492123961367161 no 1650 0.487437525810957 2348 4323132 SGTC_2774 tamoxifen 10.92 µM 0.0313581734953541 0.492177468550094 no 1651 0.487491948724321 2348 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2125 5246583 200 µM 0.0310072668473117 0.492315037219044 no 1652 0.487631872177315 2341 835267 SGTC_3084 9116877 49.47 µM 0.0307262567784456 0.492425204447001 no 1653 0.487743925582087 2352 27241325 SGTC_2567 aureobasidin a 60 nM 0.0303585405617615 0.492569364837053 no 1654 0.487890554720709 2282 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1824 st053723 68.6 µM 0.029650790680404 0.492846835595171 no 1655 0.488172778997417 2322 675225 SGTC_3300 9124615 50.48 µM 0.0296368154030033 0.492852314586963 no 1656 0.488178351877316 2337 24824903 SGTC_1203 3992-3522 103 µM 0.0291826784137401 0.493030359210946 no 1657 0.488359447986914 2360 5322312 SGTC_2176 5809774 33.9695 µM 0.0288644329750529 0.493155128317028 no 1658 0.488486356084575 2354 2870539 SGTC_819 1013-0258 27.7 µM 0.0281428871380408 0.493438015049722 no 1659 0.48877409430852 2332 5753198 SGTC_1339 1486-1321 22.7 µM 0.027559228782416 0.493666844520591 no 1660 0.48900685001094 2342 3469382 SGTC_1892 st058411 7.36 µM 0.0267034232779798 0.494002375924927 no 1661 0.489348141363137 2363 3934738 SGTC_2277 7947813 106.88 µM 0.0255288452488442 0.494462893746727 no 1662 0.489816570399839 2322 1246798 SGTC_1177 0983-0204 23.6 µM 0.0234627062765439 0.49527298416744 no 1663 0.490640593184894 2368 766818 SGTC_2258 7960471 200 µM 0.0234054256263982 0.495295443020516 no 1664 0.490663438584383 2268 2974708 SGTC_1950 st077106 7.18 µM 0.0232847753147339 0.49534274818213 no 1665 0.49071155798065 2251 13831864 SGTC_25 0118-0223 35.662 µM 0.0231396667435289 0.495399643143914 no 1666 0.490769432331242 2352 5333628 SGTC_741 4582-0002 126 µM 0.0220811582776582 0.495814671686632 no 1667 0.491191608164309 2351 2912688 SGTC_575 k072-0246 11.9 µM 0.021720243030617 0.495956183307885 no 1668 0.491335557988977 2363 6796779 SGTC_695 3505-6186 243 µM 0.020680909236572 0.496363699517984 no 1669 0.491750098993031 2364 1819379 SGTC_3260 9137109 49.47 µM 0.0205529468352298 0.49641387303753 no 1670 0.491801137756831 2368 17478346 SGTC_1516 st013856 110 µM 0.0198352262824991 0.49669528927734 no 1671 0.492087408447978 2339 5281404 A mutagen and neurotoxin. SGTC_2187 6125751 200 µM 0.0197415610303929 0.496732015287435 no 1672 0.492124768161849 2330 874498 SGTC_2801 7907800 81.82 µM 0.0189336142737409 0.497048811161018 no 1673 0.492447032014951 2365 6620925 SGTC_1020 4335-0961 93.3 µM 0.0187703552168868 0.497112825259641 no 1674 0.492512151382664 2354 669075 SGTC_1247 0448-0043 5.84 µM 0.0177684301206295 0.497505683021177 no 1675 0.492911794948419 2353 3089013 YGL099W LSG1 SGTC_1930 st074634 34.3 µM 0.0170778638241006 0.497776457517529 no 1676 0.493187249223596 2382 684253 YOR116C RPO31 SGTC_385 1494-0393 12.4 µM 0.0130629324192678 0.499350748513813 no 1677 0.494788792159277 2375 3090647 SGTC_657 3534-0529 86.7 µM 0.0118451134268148 0.499828269503181 no 1678 0.495274593939183 2375 1049549 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.010969187348048 0.499828269503181 no 1679 0.495624015140718 2382 2346 DNA damaging agent; causes G2/M arrest. SGTC_317 4495-0002 170 µM 0.0108242031117908 0.499771419471789 no 1680 0.495681852048682 2365 15991618 SGTC_2873 9040596 71.43 µM 0.00949352163825077 0.499249643913621 no 1681 0.496212689718471 2316 6463863 SGTC_1255 0566-0045 221 µM 0.00934371920962445 0.499190904716898 no 1682 0.496272449590181 2370 2788469 SGTC_627 1391-0720 175 µM 0.00893947221736616 0.499032395070763 no 1683 0.496433714067541 2368 997839 SGTC_2861 9024595 19.48 µM 0.00819090221845695 0.498738873047648 no 1684 0.496732339328836 2388 16482810 SGTC_266 formosanin C 406 nM 0.00659839581526593 0.498114437319194 no 1685 0.497367640028125 2392 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2819 7996655 46.38 µM 0.00615613681666442 0.497941024441065 no 1686 0.497544072252373 2394 6456960 SGTC_328 k915-0120 63.5 µM 0.00582299166602594 0.497810396128795 no 1687 0.497676975553893 2391 6624543 SGTC_1981 st071826 47 µM 0.00547079983057718 0.497672299746992 no 1688 0.497817477526998 2363 11838600 SGTC_2572 astragaloside iv 100 µM 0.00543465115964185 0.497658125667128 no 1689 0.497831898545827 2381 45006101 An anti-inflammatory agent. SGTC_1756 st041558 35.5 µM 0.00456023503848302 0.497315263549812 no 1690 0.498180735740075 2402 3955792 SGTC_760 0568-0725 82.9 µM 0.00423654528781225 0.497188343971569 no 1691 0.498309868017695 2398 3916171 SGTC_2373 9071805 200 µM 0.00338272011931059 0.496853558340581 no 1692 0.498650492495333 2398 10149009 SGTC_486 niguldipine 82 µM 0.00198382945122492 0.496305056925441 no 1693 0.499208567073925 2402 1236 A calcium channel blocker. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.00124782278638212 0.496016473353111 no 1694 0.49950219086125 2404 688669 SGTC_1011 4112-3381 17.4 µM 0.000658950029996873 0.495785581552415 no 1695 0.499737116991387 2400 2877139 SGTC_1660 st012960 28.1 µM 8.66499563187029e-05 0.495561189106103 no 1696 0.499965431668873 2403 24207266 SGTC_2916 7875993 68.79 µM 0 0.495527214749802 no 1697 0.5 2406 1299250 SGTC_2570 licareol 100 µM -0.000741292719708823 0.495236564564119 no 1698 0.499704267019039 2407 443158 SGTC_2321 7390090 138.78 µM -0.000802482856405347 0.495212572904773 no 1699 0.499679855693644 2410 649046 SGTC_1186 1319-0216 26 µM -0.00199163120187508 0.494746330684975 no 1700 0.499205454631879 2410 4565136 SGTC_3221 9128209 49.47 µM -0.00208277628956378 0.494710594735234 no 1701 0.499169093078215 2412 16460723 SGTC_799 1310-0557 151 µM -0.0027125621669593 0.494463670957962 no 1702 0.498917845590464 2418 5354492 SGTC_1600 coumarin 106 71.1 µM -0.00279430656354084 0.494431621114967 no 1703 0.49888523441811 2421 100336 A hepatotoxic, DNA x-linker. SGTC_2748 diazoxide 86.69 µM -0.004008981883442 0.493955382993328 no 1704 0.498400651909436 2418 3019 A potassium channel activatior. SGTC_3090 9117696 49.47 µM -0.00415642808493123 0.493897574289142 no 1705 0.49834182987587 2434 7923821 SGTC_3069 9117009 49.47 µM -0.00427386739235707 0.49385153037208 no 1706 0.498294978786998 2413 41904981 SGTC_1151 3909-8316 15.3 µM -0.00439775303935047 0.493802959155573 no 1707 0.498245556029067 2433 800431 SGTC_1230 0170-0365 3.77 µM -0.00474433776692158 0.493667075931781 no 1708 0.498107290172692 2420 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1136 pergolide 1.05886 µM -0.00615023386581618 0.493115883077421 no 1709 0.497546427144465 2422 47811 A dopamine receptor agonist. SGTC_3064 1327-0027 10 µM -0.00646633214662428 0.492991955980644 no 1710 0.497420324685127 2407 16000455 YPR107C YTH1 SGTC_3017 9080681 49.47 µM -0.00748275791273384 0.49259346844078 no 1711 0.497014839351981 2428 16451914 SGTC_296 1222-0039 74.9 µM -0.00827730875073971 0.492281971617262 no 1712 0.496697869278379 2432 5984176 SGTC_1226 3909-7979 35.4 µM -0.00860255740612896 0.492154462025637 no 1713 0.49656811845999 2434 6615510 SGTC_2049 5262831 67.185 µM -0.00972792701299279 0.491713281476713 no 1714 0.496119179822615 2427 763417 SGTC_1710 st031758 61.5 µM -0.0103415817092532 0.491472713625471 no 1715 0.495874379348112 2426 5394341 SGTC_754 3474-0146 171 µM -0.0105003732115986 0.491410463922296 no 1716 0.49581103414376 2430 24762078 SGTC_2669 eugenol 100 µM -0.0108282075366389 0.491281946440152 no 1717 0.495680254607919 2419 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_271 rotenone 740 µM -0.011101195238879 0.491174930599341 no 1718 0.495571354818222 2471 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2290 7904846 200 µM -0.0123071925968774 0.490702166748391 no 1719 0.495090264464185 2439 2962154 SGTC_511 blebbistatin 171 µM -0.0125214802410679 0.490618165049683 no 1720 0.495004782650214 2446 3476986 A myosin inhibitor. SGTC_2107 5363541 170.161 µM -0.0136610184283153 0.490171468149845 no 1721 0.494550211665823 2433 244052 SGTC_859 0439-0102 54.6 µM -0.0142651865640863 0.489934640302668 no 1722 0.494309206950934 2432 610143 SGTC_1207 2099-0101 141 µM -0.0167425898230291 0.488963561093357 no 1723 0.49332098507488 2438 5837381 SGTC_2394 5221648 200 µM -0.0171860460151431 0.48878974425652 no 1724 0.493144097106746 2450 788586 SGTC_672 1441-0018 53.7 µM -0.0173904644041465 0.488709621255975 no 1725 0.493062558154868 2455 251141 SGTC_2796 7949634 45.45 µM -0.0181740038951642 0.488402512551862 no 1726 0.492750020548859 2432 2971588 SGTC_3306 9127676 59.7925 µM -0.018436839857837 0.488299495393103 no 1727 0.49264518173745 2452 41905287 SGTC_517 1365-0151 113 µM -0.0218320310512958 0.486968840872424 no 1728 0.4912909715938 2518 768657 SGTC_644 1498-1197 63.3 µM -0.0219928592363525 0.486905812042083 no 1729 0.491226825832781 2468 6741615 SGTC_131 0141-0277 33.849 µM -0.0224706121427309 0.486718581827011 no 1730 0.491036277095836 2465 1547771 SGTC_45 0kpi-0036 14.9 µM -0.0229882761927337 0.486515713836538 no 1731 0.490829812361133 2455 2795021 SGTC_3215 9129942 49.47 µM -0.0237017392730182 0.486236119657006 no 1732 0.490545259328692 2460 17682944 SGTC_2154 5570129 200 µM -0.0246477121091129 0.485865419270609 no 1733 0.490167981042425 2443 673366 SGTC_2075 5212009 200 µM -0.0249829285636672 0.485734060200329 no 1734 0.490034290196001 2459 780898 SGTC_2121 5257820 149.641 µM -0.027117316984379 0.484897708333157 no 1735 0.48918308144162 2452 791256 SGTC_639 0833-0042 114 µM -0.0272353323484765 0.484851466372488 no 1736 0.489136017505977 2474 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_887 0885-0007 9.62 µM -0.0275988723830951 0.484709021762076 no 1737 0.488991040516009 2547 5719458 SGTC_677 0929-0063 136 µM -0.0278826438619442 0.484597833938838 no 1738 0.488877875626883 2460 1539583 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0279441764996173 0.48457372427384 no 1739 0.488853337217612 2480 6710655 SGTC_2338 7999974 200 µM -0.0292936093896433 0.484045004977922 no 1740 0.48831521184254 2502 315925 SGTC_2322 7413319 38.22 µM -0.029875340826535 0.483817086246731 no 1741 0.488083236119363 2505 1840400 SGTC_2348 9022543 33.42 µM -0.0299186434101295 0.483800120776393 no 1742 0.488065968606754 2473 3162678 YDL140C RPO21 SGTC_3088 9117578 49.47 µM -0.0302090788562232 0.483686332160425 no 1743 0.487950153978515 2469 678341 SGTC_643 k048-0106 28.4 µM -0.0302998647324702 0.483650763774026 no 1744 0.487913952226152 2514 6763920 SGTC_2790 5423970 71.43 µM -0.0318328276626854 0.483050194434524 no 1745 0.487302683603142 2496 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0322886812364952 0.482871611902025 no 1746 0.487120917782274 2499 6708760 SGTC_755 1995-0008 37.3 µM -0.0325624155628736 0.482764376990778 no 1747 0.487011770980668 2448 689533 SGTC_142 0335-0849 62.6745 µM -0.03288620172232 0.482637535977664 no 1748 0.48688266813778 2472 3889043 YPR107C YTH1 SGTC_1235 benzylparaben 21.5 µM -0.0330465393421067 0.482574725461675 no 1749 0.486818737430974 2485 7180 SGTC_66 0109-0187 42.4 µM -0.0344660119631305 0.482018681565245 no 1750 0.486252772380606 2459 759417 SGTC_2756 carbadox 75.1 µM -0.0364864080912731 0.481227301076214 no 1751 0.485447258132973 2496 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2843 9000894 45.46 µM -0.0379167644835774 0.480667081158444 no 1752 0.484877023267731 2464 2242070 SGTC_2166 5933061 31.504 µM -0.0389119077118088 0.480277341272613 no 1753 0.484480311389469 2587 2877375 SGTC_2536 dehydroabietamide 32.04 µM -0.0399725380970844 0.479861974629385 no 1754 0.484057510106287 2511 3983547 SGTC_1371 2421-0008 32.7 µM -0.0405434432558056 0.47963840439084 no 1755 0.483829936393223 2521 2827552 SGTC_1253 0550-0034 176 µM -0.0412089415681496 0.479377798937773 no 1756 0.483564662694401 2525 5969915 SGTC_1305 1181-0477 144 µM -0.0412167032746598 0.479374759548284 no 1757 0.483561568850065 2501 6252086 SGTC_3071 9117417 49.47 µM -0.0416191468435692 0.479217169208356 no 1758 0.483401154745805 2502 45595590 YGL055W OLE1 SGTC_890 0929-0006 47.2 µM -0.0428901105265829 0.478719501999943 no 1759 0.48289456607708 2486 1378169 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0435295542985253 0.478469129531643 no 1760 0.482639702962081 2535 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2191 5911152 200 µM -0.0442782184530635 0.478176002924386 no 1761 0.482341316899813 2491 2875902 SGTC_2057 5236571 38.335 µM -0.0453520952136789 0.477755565551005 no 1762 0.481913332074467 2496 54684039 YBR257W POP4 SGTC_895 0964-0006 13.7 µM -0.0474337329020911 0.476940646973273 no 1763 0.481083772150167 2480 6738897 SGTC_1642 st009582 77.7 µM -0.0477389965449545 0.476821150526228 no 1764 0.480962127384812 2504 6739311 SGTC_3265 9137266 49.47 µM -0.0483892630660561 0.476566608541285 no 1765 0.480703008057129 2486 17224265 SGTC_693 4161-2696 114 µM -0.048890036388684 0.476370591066519 no 1766 0.480503464589099 2542 805759 SGTC_3343 9148379 18.9835 µM -0.0491103009066759 0.476284374833825 no 1767 0.480415697188937 2513 1955036 SGTC_1727 st034309 9.9045 µM -0.0493141774501388 0.476204574193381 no 1768 0.480334460646628 2570 870305 SGTC_2791 5663188 71.43 µM -0.0493394784919934 0.47619467101496 no 1769 0.480324379263446 2540 54690634 SGTC_3149 9097855 49.47 µM -0.0494743355217205 0.47614188635279 no 1770 0.480270644716714 2535 25236625 YMR079W SEC14 SGTC_465 cgp-37157 41 µM -0.0513207881953691 0.475419205087811 no 1771 0.479534951672943 2486 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1766 st045414 44.774 µM -0.0525894008297062 0.474922730775448 no 1772 0.47902953109897 2499 253960 SGTC_2746 daunorubicin 9.88 µM -0.0528753605616623 0.474810825162921 no 1773 0.478915608174914 2470 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1123 mangostin 811.285 nM -0.0531480244998635 0.474704124490068 no 1774 0.478806983739585 2563 5281650 An antioxidant. SGTC_1172 0370-0043 85 µM -0.0535791165189889 0.474535430387726 no 1775 0.478635247605878 2560 376585 SGTC_2811 7967822 32.47 µM -0.055267784027722 0.473874668507485 no 1776 0.477962563772091 2555 2232244 SGTC_2853 9015042 58.44 µM -0.055412251673076 0.473818142802762 no 1777 0.477905017705679 2512 6457456 SGTC_2603 homopterocarpin 100 µM -0.0561750797402218 0.473519680628633 no 1778 0.477601166646632 2561 101795 A weak amylase inhibitor. SGTC_1447 4239-0816 81.9 µM -0.0571168647830766 0.473151220723926 no 1779 0.477226051099908 2518 1341554 SGTC_2463 5473429 200 µM -0.0572969816094273 0.473080755203224 no 1780 0.477154312365896 2587 5399405 SGTC_3086 9117350 49.47 µM -0.0576664977516003 0.472936195294382 no 1781 0.47700714009494 2513 2679265 SGTC_2860 9025725 38.96 µM -0.0585794470764917 0.472579052007822 no 1782 0.476643540711233 2533 40546248 SGTC_3185 9108267 49.47 µM -0.0585955915384234 0.47257273653585 no 1783 0.476637111047152 2557 4910486 SGTC_1938 st074717 56.4 µM -0.0589992124258561 0.47241484832837 no 1784 0.476476367706947 2487 17250979 SGTC_2799 7812892 81.82 µM -0.0604638338456777 0.471841955070703 no 1785 0.475893109768303 2556 20205235 SGTC_1801 st050089 28.441 µM -0.0617168697173689 0.471351870645893 no 1786 0.475394152743597 2508 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_867 0518-0118 155 µM -0.0617492983169858 0.471339187821412 no 1787 0.475381240232194 2529 6848158 SGTC_2299 7976368 114.88 µM -0.0637247140765957 0.470566658065913 no 1788 0.474594712875089 2560 2979718 SGTC_1819 st053448 58.6 µM -0.0643795411413548 0.470310597847994 no 1789 0.474334010015704 2534 2857616 SGTC_3186 9110464 49.47 µM -0.0646664425909353 0.470198413237415 no 1790 0.474219790904625 2582 17018021 SGTC_2270 7924575 90.91 µM -0.0648311053400046 0.470134027644176 no 1791 0.474154237529319 2597 1262135 SGTC_3063 1327-0034 4 µM -0.0661937733226791 0.469601234242827 no 1792 0.473611777036276 2511 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1249 0481-0015 10.2 µM -0.0664063451609296 0.469518125062821 no 1793 0.473527159324007 2525 4227577 SGTC_2745 rifampicin 24.3 µM -0.0670096142891954 0.469282272265818 no 1794 0.473287024654934 2570 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2649 anisomycin 9.56 µM -0.0672850957261643 0.469174574217262 no 1795 0.473177370942995 2569 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_148 3253-0744 288.01 µM -0.0676533440285623 0.469030612964508 no 1796 0.473030795119839 2513 6893655 SGTC_133 0724-0033 378.92 µM -0.0684116529867263 0.468734176014848 no 1797 0.472728972910976 2515 280309 SGTC_298 1391-0729 10 µM -0.0691461290894243 0.46844707229038 no 1798 0.472436651582822 2523 3237558 SGTC_2019 4016004 108 µM -0.0703578491737577 0.467973451769492 no 1799 0.471954419777496 2581 45595336 SGTC_1398 3558-0053 112 µM -0.0705360604463286 0.467903798800058 no 1800 0.471883499964118 2535 4532369 SGTC_2349 9023730 187.07 µM -0.0714647848842549 0.467540827529101 no 1801 0.471513925231394 2572 4126287 SGTC_1895 st058434 18.3 µM -0.0724494643602788 0.467156016958394 no 1802 0.471122110659937 2528 5393175 SGTC_447 ml7 120 µM -0.0730797914904687 0.466909702594736 no 1803 0.470871311353418 2552 4216 Selective myosin light chain kinase inhibitor. SGTC_2937 9044753 11.33 µM -0.0736347857969249 0.466692836697046 no 1804 0.470650495599045 2539 6465530 YGL099W LSG1 SGTC_2564 betulinic acid 100 µM -0.0737917431492996 0.466631506872893 no 1805 0.470588048563223 2542 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_943 3253-1379 105 µM -0.0738534001320225 0.466607415119027 no 1806 0.470563517920296 2604 668464 SGTC_3047 9092122 49.47 µM -0.0739397509745972 0.466573674730319 no 1807 0.470529162847866 2575 17173831 SGTC_945 3381-0768 11.3 µM -0.0743327056281739 0.466420136211479 no 1808 0.470372826839591 2549 1126236 YIL048W NEO1 SGTC_2395 5646831 180.19 µM -0.0748638550476557 0.466212609028139 no 1809 0.470161517657762 2627 6808628 SGTC_397 arbidol 50 µM -0.0758320734960629 0.465834336803688 no 1810 0.469776349311492 2683 131410 A RNA synthesis inhibitor. SGTC_303 1348-1668 34.2 µM -0.076024355148285 0.46575921815442 no 1811 0.469699860830504 2567 5380509 SGTC_766 1391-0721 126 µM -0.077207469078662 0.465297038129537 no 1812 0.4692292499599 2571 1020919 YIL115C NUP159 SGTC_1717 st033143 58.0435 µM -0.0782362092024733 0.464895201807656 no 1813 0.468820079749185 2594 674616 SGTC_703 3875-0075 71.8 µM -0.0790452908445528 0.464579191443543 no 1814 0.468498299426462 2570 2850814 SGTC_2370 9071495 200 µM -0.0795614459926179 0.464377603700053 no 1815 0.468293029805648 2604 21791103 SGTC_2499 avocadenofuran 51.48 µM -0.0798335728143074 0.464271326481365 no 1816 0.468184811143362 2555 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1744 st037937 38.9 µM -0.080696951526637 0.463934156899915 no 1817 0.467841480620402 2643 1016152 SGTC_587 k089-0003 57 µM -0.081802233873862 0.463502556126519 no 1818 0.467401989827782 2545 9659696 SGTC_1521 st012942 49.4 µM -0.0835427285498191 0.462822999096058 no 1819 0.466710001823793 2785 24207259 SGTC_3126 9127922 49.47 µM -0.0837720144643472 0.46273348497326 no 1820 0.466618849504412 2749 45595682 SGTC_514 4466-0038 2.65 nM -0.0838646216628737 0.462697331293513 no 1821 0.466582034128275 2626 5722064 SGTC_1362 1611-0397 101 µM -0.0839707449852761 0.462655901322808 no 1822 0.466539845858529 2554 27816 SGTC_1963 st076565 50.3 µM -0.0878283810267724 0.461150179673058 no 1823 0.465006540062986 2571 4914280 SGTC_917 harmaline 728.087 nM -0.0885747765812084 0.460858908406139 no 1824 0.464709927324242 2645 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_836 0330-0104 1.35 µM -0.0893689714110743 0.460549007148126 no 1825 0.464394341000982 2572 46494820 SGTC_843 0310-0051 143 µM -0.0902110577250225 0.460220444420131 no 1826 0.464059748681573 2578 2065037 SGTC_2939 9044578 71.43 µM -0.0902791765708274 0.460193867196316 no 1827 0.464032683629937 2579 2653634 SGTC_1034 k072-0165 12.7 µM -0.0916741315322746 0.459649651361282 no 1828 0.463478475435364 2581 5835461 SGTC_1659 st012954 42.1 µM -0.0922056085038661 0.459442325299058 no 1829 0.46326734104436 2670 24207262 SGTC_1513 0337-0559 19 µM -0.0928305064444273 0.45919857037417 no 1830 0.463019107504388 2589 775073 SGTC_1842 st055362 61.2 µM -0.0937388879169937 0.458844263959157 no 1831 0.462658289088142 2579 676032 SGTC_173 1273-0061 2.693 µM -0.0948470007560752 0.458412098324981 no 1832 0.4622181769566 2662 2847414 YPL266W DIM1 SGTC_1251 0490-5699 265 µM -0.0951109585947066 0.458309161610221 no 1833 0.462113346919029 2583 3883818 SGTC_539 4859-0462 2.54 µM -0.095390970097433 0.458199967438898 no 1834 0.462002144095388 2699 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1327 1436-0082 2.18 µM -0.0961729841171162 0.457895027511109 no 1835 0.461691593444058 2633 15992205 SGTC_1386 3228-0095 33.8 µM -0.0963483596590262 0.457826644658337 no 1836 0.461621952126417 2651 870181 SGTC_2032 5185112 25.99 µM -0.0967043819761395 0.457687827422512 no 1837 0.461480579915095 2642 5718189 SGTC_2004 4023728 41.89 µM -0.0968061155869927 0.457648161253699 no 1838 0.461440183606236 2613 360084 YDR527W RBA50 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0979297069994954 0.45721009852397 no 1839 0.460994055291441 2675 5393153 SGTC_301 4119-0100 24.5 µM -0.0985970021497327 0.456949959897271 no 1840 0.460729125180968 2591 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1856 st057054 55.7 µM -0.0990525373030914 0.456772384466228 no 1841 0.460548278215366 2750 1266018 SGTC_3105 9121040 49.47 µM -0.100333805159432 0.456272970633757 no 1842 0.460039660128549 2558 41448907 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.100503379607099 0.456206878899007 no 1843 0.45997234994315 2683 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3146 9095609 49.47 µM -0.100953075329862 0.456031615614306 no 1844 0.459793855128187 2661 17173999 SGTC_2442 5158906 48.48 µM -0.10154172153595 0.455802211049728 no 1845 0.459560219847694 2698 1893835 SGTC_2300 7976697 71.57 µM -0.101921800117178 0.455654096349728 no 1846 0.459409373039088 2622 2236109 SGTC_446 go6976 132 µM -0.102340693722397 0.455490862771479 no 1847 0.459243127968924 2632 3501 A protein kinase C inhibitor. SGTC_1949 st076024 69.1 µM -0.102489465154592 0.455432891639646 no 1848 0.459184087202735 2558 2921930 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.103269160779182 0.455129086505839 no 1849 0.458874675431166 2635 688798 SGTC_921 1561-0023 372 µM -0.104047786435858 0.45482572446715 no 1850 0.458565713123071 2570 24050882 SGTC_1164 k060-0068 93.7 µM -0.104106688860285 0.454802776434861 no 1851 0.458542341381147 2593 5963676 SGTC_1713 st033146 12.748 µM -0.105229943004426 0.45436519229021 no 1852 0.458096675768236 2635 674619 SGTC_338 4055-0136 114 µM -0.105543274563616 0.454243138120964 no 1853 0.457972366790966 2588 2900563 SGTC_483 fpl-64176 144 µM -0.106491319869885 0.453873865958119 no 1854 0.457596270994548 2596 3423 SGTC_1762 st045503 25.4615 µM -0.106851617483418 0.453733537239788 no 1855 0.457453348504666 2655 4645554 SGTC_3056 9094900 49.47 µM -0.107177586778182 0.453606583691728 no 1856 0.457324048077562 2644 25236784 SGTC_3289 9119912 71.43 µM -0.107236953624884 0.453583462907896 no 1857 0.457300499846547 2672 17014829 SGTC_1765 st044815 90.4 µM -0.107428165993026 0.453508995144045 no 1858 0.457224655284361 2670 645695 SGTC_1054 3429-0080 167 µM -0.107716268136109 0.453396796690867 no 1859 0.457110382246565 2656 1162877 SGTC_3123 9126162 49.47 µM -0.107932169190793 0.453312718655992 no 1860 0.457024749423525 2611 25239884 SGTC_1978 st071761 42 µM -0.108271587297875 0.453180543786924 no 1861 0.456890130074939 2616 5147680 SGTC_2313 7726885 200 µM -0.109078791528533 0.452866226340771 no 1862 0.45656999820587 2688 726423 SGTC_1915 st067105 30.6 µM -0.109094082456956 0.452860272486919 no 1863 0.456563934195973 2566 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.109101591930334 0.452857348514847 no 1864 0.456560956125382 2620 6708514 SGTC_933 2914-0560 114 µM -0.109351910565264 0.452759883130925 no 1865 0.456461687370412 2647 463887 SGTC_100 0086-0128 49.5915 µM -0.11089407356482 0.452159481413057 no 1866 0.455850172613389 2621 93297 SGTC_1183 1254-0324 198 µM -0.111311935631942 0.45199681628364 no 1867 0.455684495479825 2701 5799357 SGTC_2723 salbutamol 83.58 µM -0.112643434401313 0.45147854500946 no 1868 0.455156624248502 2671 9884233 β2-adrenoceptor agonist SGTC_1739 st037196 92.5 µM -0.116178267530025 0.450103053533834 no 1869 0.453755630052837 2659 612214 SGTC_272 doxorubicin 8.13 µM -0.116866188966653 0.4498354353321 no 1870 0.453483045903055 2585 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1387 3342-1166 1.8 µM -0.117364357155427 0.449641650002246 no 1871 0.453285663848964 2692 3418228 SGTC_3117 9124945 49.47 µM -0.120437849604557 0.448446341707237 no 1872 0.452068154976777 2595 17592065 SGTC_2480 5767542 37.17 µM -0.122216516722089 0.447754815415495 no 1873 0.451363773030304 2663 2867358 SGTC_441 propafenone 146 µM -0.122711207844434 0.447562513054715 no 1874 0.451167894185273 2619 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1689 st020265 53.493 µM -0.123799731207862 0.447139412450638 no 1875 0.450736922321324 2701 5758320 YPR016C TIF6 SGTC_2262 9014885 67.46 µM -0.125640372639448 0.446424106479277 no 1876 0.450008301707807 2674 6457424 SGTC_683 panaxydol 45 µM -0.125901979618404 0.446322455451088 no 1877 0.449904757819254 2700 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2184 6075246 200 µM -0.127022286312852 0.445887184690737 no 1878 0.449461379747614 2689 2267320 SGTC_839 0122-0028 230 µM -0.127180140870143 0.445825858970631 no 1879 0.449398911512327 2631 759448 SGTC_2927 9011802 47.9 µM -0.127471720186282 0.445712585247637 no 1880 0.449283527294707 2727 43912568 SGTC_3287 9117173 37.0625 µM -0.127642686177606 0.4456461698589 no 1881 0.449215874362252 2626 2789709 SGTC_888 0916-0002 6.97 µM -0.12793700592464 0.445531838644711 no 1882 0.449099412589046 2798 2802138 YIL048W NEO1 SGTC_3073 9114972 49.47 µM -0.128579166278034 0.445282401281918 no 1883 0.448845326174041 2683 41905075 SGTC_2229 7354935 190 µM -0.131721937361937 0.44406195418047 no 1884 0.447602116601292 2636 318112 SGTC_3080 9117754 49.47 µM -0.131945036841433 0.443975336930218 no 1885 0.447513882881636 2781 9550191 SGTC_1200 1643-0193 18.4 µM -0.132797430475802 0.443644424070922 no 1886 0.44717679327246 2612 5403974 SGTC_1088 bifonazole 369 nM -0.133059235681829 0.443542794974246 no 1887 0.44707326681249 2612 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3267 9137951 49.47 µM -0.13310652525284 0.443524438224016 no 1888 0.447054567332316 2611 16643986 SGTC_233 rapamycin 362 pM -0.134124652024201 0.443129253715862 no 1889 0.446652003134913 2684 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3023 9089636 49.47 µM -0.134338440042744 0.443046279362612 no 1890 0.446567478978562 2621 17249241 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.134464124057903 0.442997500666921 no 1891 0.446517789135128 2698 279621 SGTC_2840 9008771 71.43 µM -0.134517833677802 0.442976655915171 no 1892 0.446496555007482 2805 2992978 SGTC_2214 7179297 48.276 µM -0.135723526805865 0.44250876697352 no 1893 0.446019924058878 2643 769744 SGTC_1679 SEC14.276 6.7 µM -0.137030676432341 0.442001596778388 no 1894 0.445503273766831 2810 1005053 YMR079W SEC14 SGTC_2783 7738165 71.43 µM -0.138272438141068 0.441519884932652 no 1895 0.445012553712389 2713 17201110 SGTC_372 0155-0182 15.9 µM -0.138358768152838 0.441486398470366 no 1896 0.44497844089596 2658 771486 SGTC_2823 7987624 58.44 µM -0.138386669825474 0.441475575807779 no 1897 0.444967415794762 2785 2239440 SGTC_3096 9117468 49.47 µM -0.13943612521201 0.441068538768565 no 1898 0.444552763691729 2664 41316311 SGTC_982 1491-0518 27.5 µM -0.139801264526977 0.440926932052594 no 1899 0.444408507080372 2699 3091256 SGTC_3211 9128781 49.47 µM -0.142759366107698 0.439780014163926 no 1900 0.443240114722958 2818 17194361 SGTC_2543 pimpinellin 60.67 µM -0.143746807071706 0.439397274630096 no 1901 0.442850204148996 2662 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1428 4049-0204 61.7 µM -0.14425548363876 0.439200129855569 no 1902 0.442649364730119 2770 X1428 SGTC_773 4358-1457 44.6 µM -0.144664312219382 0.43904169350376 no 1903 0.442487958706076 2635 1186886 SGTC_193 1273-0060 1.558 µM -0.1447290262879 0.439016615278641 no 1904 0.442462410387028 2637 2847393 YHR072W ERG7 SGTC_1612 st002233 45.4 µM -0.145603353407513 0.438677816971336 no 1905 0.442117260282278 2660 1035021 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.14606925193289 0.438497301465171 no 1906 0.441933359718356 3018 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_252 miconazole 1.30953 nM -0.14628361462431 0.438414249498984 no 1907 0.441848750172938 2727 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1466 k213-0079 57.5 µM -0.1478350369345 0.437813252678728 no 1908 0.441236478830247 2635 3657981 SGTC_2238 6671620 73.2395 µM -0.147887023512735 0.437793116364494 no 1909 0.441215964665743 2618 729941 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.147966184383219 0.437762454756606 no 1910 0.441184727692169 2666 15053 SGTC_1181 1222-0449 220 µM -0.148059667668622 0.437726246087754 no 1911 0.441147839547827 2824 658318 SGTC_1435 4092-0789 56.7 µM -0.149297159283593 0.437246980521759 no 1912 0.440659578358003 2710 2248285 SGTC_1876 myriocin 605 nM -0.149378970448226 0.437215299282063 no 1913 0.440627302347062 2757 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1602 st001878 87.6 µM -0.152483990872054 0.436013184616529 no 1914 0.439402608108839 2869 595405 YLR310C CDC25 SGTC_2095 5432005 200 µM -0.153194184086186 0.435738314567898 no 1915 0.439122571982206 2718 783734 SGTC_2727 riluzole 51.77 µM -0.15327541795597 0.435706876145074 no 1916 0.43909054261234 2680 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3004 9076122 71.4286 µM -0.153975473156217 0.435435963753659 no 1917 0.438814537262909 2800 44782551 SGTC_3150 9097574 49.47 µM -0.155264864656395 0.434937065153695 no 1918 0.438306256803014 2761 17217476 SGTC_1105 epirubicin 18.1 µM -0.156866463042957 0.434317510016168 no 1919 0.4376750456001 2676 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2589 lobaric acid 100 µM -0.157126207348953 0.434217046853811 no 1920 0.437572691819634 2725 73157 A novel microtubule depolymerizer. SGTC_2205 7238770 200 µM -0.157395409356572 0.434112930151953 no 1921 0.437466615584139 2777 279867 SGTC_2104 5389443 200 µM -0.15808351463749 0.4338468190017 no 1922 0.437195495339551 2839 2244536 SGTC_492 tmb-8 126 µM -0.158541825397849 0.433669592978371 no 1923 0.437014932749381 2689 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2955 9076254 12.21 µM -0.158681887979355 0.433615434276522 no 1924 0.436959754329153 2738 16459619 SGTC_957 1187-1561 14.1 µM -0.158940278601177 0.433515524348471 no 1925 0.43685796314894 2676 1538454 SGTC_1294 1000-1494 117 µM -0.159990982197185 0.43310930064081 no 1926 0.436444088938349 2712 712797 YDL207W GLE1 SGTC_730 1436-0052 41.2 µM -0.160314328764161 0.432984302381056 no 1927 0.436316736068436 2679 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1425 4048-4433 7.33 µM -0.161296139957462 0.432604798155214 no 1928 0.435930081661657 2727 23734946 SGTC_2120 5538279 151.968 µM -0.162000911974628 0.432332417526011 no 1929 0.435652567852612 2718 2058197 SGTC_248 streptozotocin 5.23457 mM -0.1621677422176 0.432267945595388 no 1930 0.435586880750758 2790 5300 DNA alkylating agent. SGTC_1388 3346-4487 254 µM -0.162206102402156 0.432253121468913 no 1931 0.435571777209617 2760 3345614 SGTC_3281 9140613 49.47 µM -0.164023651060309 0.431550847373518 no 1932 0.434856262553606 2732 16013766 SGTC_1155 4088-0394 48.2 µM -0.164308281874807 0.431440889741249 no 1933 0.434744231154178 2678 2326248 SGTC_3177 9107506 49.47 µM -0.16485183495688 0.43123092088416 no 1934 0.434530301867163 2776 8897194 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.167917390164737 0.430047094579229 no 1935 0.433324134504255 2712 77254 SGTC_524 r073-0010 27.8 µM -0.167990571664009 0.430018841699157 no 1936 0.433295348196654 2681 2772106 SGTC_792 4534-1957 155 µM -0.170259883291351 0.429142916442065 no 1937 0.432402879531743 2769 1717904 SGTC_304 1310-0298 97 µM -0.170752554065079 0.428952797760404 no 1938 0.432209168713208 2704 1550234 SGTC_2472 5377652 49.4 µM -0.171262921841118 0.428755867293673 no 1939 0.432008516880935 2751 1610903 SGTC_531 3788-1495 174 µM -0.172146788401336 0.428414860599115 no 1940 0.431661064974099 2672 2896655 SGTC_2845 9003024 42.97 µM -0.172622790739706 0.428231235110447 no 1941 0.431473968204675 2946 2990173 SGTC_2302 7771753 200 µM -0.172994674504547 0.428087785831076 no 1942 0.4313278068212 2775 2203047 SGTC_2279 7948423 32.93 µM -0.174180380078285 0.427630479016308 no 1943 0.430861852133632 2744 1247112 SGTC_2430 5571206 200 µM -0.174562095734241 0.42748327832496 no 1944 0.430711867211203 2829 1731771 SGTC_1370 2001-0092 44.6 µM -0.175421492765528 0.427151906738489 no 1945 0.430374226822662 2854 790957 SGTC_1946 st076057 65.1 µM -0.177146221587979 0.426487030508413 no 1946 0.429696768211547 2720 953009 SGTC_1694 st024011 44.9 µM -0.177226315057574 0.426456159848643 no 1947 0.429665313200561 2740 2787533 SGTC_2990 9074105 71.4286 µM -0.178397278229628 0.426004883637413 no 1948 0.429205493339193 2719 6502001 SGTC_2984 9022109 38.96 µM -0.178484208069621 0.42597138569787 no 1949 0.429171361103242 2744 6459207 SGTC_1687 st020778 55.3625 µM -0.179450747684906 0.425598970972683 no 1950 0.428791893572094 2745 4259299 SGTC_2735 sertaconazole 140 nM -0.180974762834643 0.425011891820306 no 1951 0.428193692623733 2719 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2865 9030313 51.95 µM -0.18287198795781 0.424281277665343 no 1952 0.427449231300584 2717 42562754 SGTC_1827 berberine 7.24 µM -0.183039394503464 0.424216822496021 no 1953 0.427383554199161 2735 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2999 9069765 71.4286 µM -0.183061548855793 0.424208292739266 no 1954 0.427374862732508 2804 2097066 SGTC_727 3032-0951 202 µM -0.183221488722164 0.424146714553864 no 1955 0.427312117100433 2794 3652836 SGTC_176 1486-1328 72.834 µM -0.183543418703365 0.42402277443653 no 1956 0.427185827084898 2813 22310231 SGTC_1173 0443-0020 122 µM -0.184011128217807 0.423842723915481 no 1957 0.427002362468554 2747 5331295 SGTC_2696 st077691 74.316 µM -0.184044067538079 0.423830044118433 no 1958 0.426989442223341 2877 757133 SGTC_1004 4084-0029 199 µM -0.184212310846182 0.423765281079709 no 1959 0.426923451045446 2872 716894 YLR208W SEC13 SGTC_1267 0828-0272 9.49 µM -0.185285264713052 0.423352310173786 no 1960 0.426502647490123 2861 745334 SGTC_1937 st074714 47.2 µM -0.18530132765581 0.423346128320918 no 1961 0.426496348372329 2704 17250970 SGTC_3133 9127736 49.47 µM -0.186692087378154 0.422810963605794 no 1962 0.425951030192211 2707 27243420 SGTC_1347 1493-0251 600 nM -0.188150792957732 0.42224980634793 no 1963 0.425379222509818 2866 3986378 SGTC_337 1315-0038 354 µM -0.189427260130592 0.421758884766517 no 1964 0.424878980363972 2753 1626437 SGTC_1594 piperine 70.1 µM -0.191141298085974 0.421099867447646 no 1965 0.424207446437152 2748 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_809 3998-0021 90 µM -0.191173857077368 0.421087351223638 no 1966 0.424194692443874 2854 715485 SGTC_1271 0832-2808 169 µM -0.191418976432003 0.420993125781401 no 1967 0.424098676951385 2895 3663794 SGTC_618 k072-0232 33.2 µM -0.192707947873287 0.420497711534265 no 1968 0.423593849313269 2843 5872756 YGL099W LSG1 SGTC_930 2810-3379 265 µM -0.194457677495811 0.419825407167242 no 1969 0.422908765802136 2958 1015764 SGTC_26 0302-0163 425.158 µM -0.195989929059305 0.419236857149643 no 1970 0.422309024290306 2746 3100915 SGTC_150 3970-0969 77.2 µM -0.196289730654269 0.419121722062927 no 1971 0.422191699396974 2857 6615640 SGTC_2786 7743617 45.45 µM -0.196386053723348 0.419084731851662 no 1972 0.422154005619508 2786 583674 SGTC_1274 0865-0114 173 µM -0.197680734462041 0.418587615054421 no 1973 0.421647431965663 2800 870624 SGTC_2376 9072922 81.32 µM -0.198037789208036 0.418450540065097 no 1974 0.421507748844338 2877 17087968 SGTC_2597 laccaic acid a 100 µM -0.198172908134052 0.418398669858418 no 1975 0.421454891644978 2880 5491415 A textile dye. SGTC_3336 9143619 71.43 µM -0.198545013460183 0.41825583132847 no 1976 0.421309335007549 2752 45595730 SGTC_563 tetrahydrosecaminediol 614 µM -0.198919078647958 0.418112251339807 no 1977 0.421163022568419 2900 334274 A psychoactive constituent of the cannabis plant. SGTC_1358 1509-0022 2.48 µM -0.201748464647862 0.417026583587584 no 1978 0.420056686115804 2825 3258434 SGTC_283 0987-0079 11.7 µM -0.201840763795495 0.416991177956575 no 1979 0.42002060621882 2846 411556 SGTC_2354 9060492 162 µM -0.201845518318881 0.416989354156222 no 1980 0.420018747685578 2905 6471895 SGTC_1738 st035555 74 µM -0.202033102483001 0.41691739967056 no 1981 0.419945422852173 2876 5331140 SGTC_1131 3454-3128 32.3 µM -0.202044250157859 0.41691312367645 no 1982 0.419941065421465 2940 710982 SGTC_1929 genistein trimethyl ether 50.5 µM -0.202251990993873 0.416833440823336 no 1983 0.419859864966037 2911 136420 SGTC_2138 5575593 77.673 µM -0.203172533136614 0.416480390957563 no 1984 0.41950009023646 2764 762213 SGTC_384 k007-0144 5.16 µM -0.205090704922985 0.41574494308186 no 1985 0.418750629239284 2831 6824886 SGTC_2803 7707263 71.43 µM -0.206712259025433 0.415123451636354 no 1986 0.418117291430723 2801 2199229 SGTC_21 0849-0113 22.993 µM -0.207239759934716 0.414921322577078 no 1987 0.417911308663599 2784 1560156 SGTC_156 3474-0145 5.642 µM -0.207999039619964 0.414630419522478 no 1988 0.417614858613986 2700 2265471 SGTC_812 4251-0442 148 µM -0.208129355961955 0.414580496085574 no 1989 0.417563983137711 2770 5723007 SGTC_3030 9087619 49.47 µM -0.209277657384091 0.414140648184913 no 1990 0.417115746212899 2818 25236973 SGTC_1086 cerivastatin 2.18 µM -0.213664132004262 0.412461439098909 no 1991 0.415404491951307 2768 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2704 st078022 71.1 µM -0.21405361207451 0.412312417156667 no 1992 0.415252624767418 2935 54697681 SGTC_113 0099-0221 2.5 µM -0.21407863961187 0.412302841611616 no 1993 0.41524286639109 2946 89219 SGTC_452 diindolylmethane 8 µM -0.214764176959377 0.412040575086424 no 1994 0.414975591907811 2889 3071 Inhibits expression of several cancer promoting factors. SGTC_27 0485-0001 32.618 µM -0.215007641353031 0.411947442181476 no 1995 0.414880680472964 2750 2054479 SGTC_2251 lansoprazole 556 µM -0.216435436476483 0.411401364944662 no 1996 0.414324173246459 2790 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1563 conessine 56.1 µM -0.216856769102145 0.411240254010071 no 1997 0.414159984559082 2917 441082 An anti-amoebic, histamine inhibitor. SGTC_519 k048-0011 62.8 µM -0.216885900066335 0.411229115342862 no 1998 0.414148633097052 2914 6836379 SGTC_3280 9140961 49.47 µM -0.217581800827927 0.410963048396168 no 1999 0.41387748280756 2766 4901226 SGTC_2361 9034121 116 µM -0.217636746192869 0.410942042624436 no 2000 0.413856075680741 2821 6496917 SGTC_426 0988-0037 14.6 µM -0.218371455418888 0.410661185726494 no 2001 0.413569852069885 2815 5383008 SGTC_3314 9135860 59.4275 µM -0.218534045969265 0.410599038509349 no 2002 0.413506517219081 2835 25252478 SGTC_2438 5259590 200 µM -0.220095214471179 0.410002425317354 no 2003 0.412898500867194 2917 1201127 SGTC_3031 9088762 49.47 µM -0.220231077152156 0.409950514124903 no 2004 0.412845597328131 2753 205253 SGTC_1497 4476-2978 41.3 µM -0.222242311429106 0.409182235275394 no 2005 0.412062628918581 2876 1528379 SGTC_1606 st000094 49.2 µM -0.222413256226142 0.409116951475877 no 2006 0.411996096633224 2848 1242210 SGTC_318 1488-0629 67.2 µM -0.223048040054808 0.408874549674246 no 2007 0.411749058800539 2880 3662576 SGTC_834 0312-0008 75.7 µM -0.223087091574401 0.408859638398086 no 2008 0.411733862322594 2782 6385573 YIL048W NEO1 SGTC_186 3455-3465 67.277 µM -0.223194756490663 0.408818528740012 no 2009 0.411691966366578 2787 755278 SGTC_1456 k015-0012 13 µM -0.223679779097494 0.408633345168684 no 2010 0.411503240626018 2814 2989616 SGTC_2679 rapamycin 1 nM -0.225052752519139 0.408109249147828 no 2011 0.410969118064113 2888 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1045 1348-1485 165 µM -0.226298133130789 0.407634000405518 no 2012 0.410484775139839 2796 6810614 SGTC_1059 3448-6867 171 µM -0.226945915487403 0.407386854359252 no 2013 0.410232899002099 2758 3934407 SGTC_2780 5215298 71.43 µM -0.227171237806257 0.407300896590492 no 2014 0.410145295973401 2947 2834131 SGTC_3175 9106517 49.47 µM -0.230257301070656 0.406124051321409 no 2015 0.408945918996096 2898 41468073 SGTC_1724 st037281 8.293 µM -0.230522282714722 0.406023042081937 no 2016 0.408842975290436 2809 574124 YDL195W SEC31 SGTC_2706 st078239 82.5 µM -0.231169407317229 0.405776388794637 no 2017 0.408591597887008 2810 15434492 SGTC_2983 9022671 12.99 µM -0.231406541740803 0.405686013728597 no 2018 0.408499491750534 3016 6405161 SGTC_2580 diallyl disulphide 81.36 µM -0.233500741086743 0.40488810540316 no 2019 0.407686297076969 2836 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1993 st073995 70.8 µM -0.233900266287401 0.404735927593142 no 2020 0.407531203238765 2844 3098394 SGTC_2681 menadione 3.18 µM -0.236418699427277 0.403776997396457 no 2021 0.406553893684789 2888 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1187 1391-0724 117 µM -0.23747958807367 0.40337322125874 no 2022 0.406142376345625 2848 6997986 SGTC_1116 jasmonic acid  1.58368 µM -0.238542638680509 0.402968725571136 no 2023 0.405730124366547 2984 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_619 1652-1634 108 µM -0.238755761659225 0.402887643768712 no 2024 0.405647487648629 2867 5400454 SGTC_1780 st038448 24.544 µM -0.239066547477749 0.402769414007351 no 2025 0.405526990488939 3015 728868 YDL195W SEC31 SGTC_1152 3909-8331 15.9 µM -0.23916136645662 0.402733344551713 no 2026 0.405490229275286 2840 16001939 SGTC_235 0330-0087 5 mM -0.240642382956423 0.402170068574363 no 2027 0.404916149205431 2853 46494818 YHR062C RPP1 SGTC_155 k072-0202 43.6 µM -0.24117687884282 0.401966833217859 no 2028 0.404709015031874 2784 5857737 SGTC_1378 2093-0007 380 nM -0.241345266730815 0.401902811323393 no 2029 0.404643764892105 2944 3618014 SGTC_1159 4092-0538 61.2 µM -0.242166295037907 0.401590690102044 no 2030 0.404325655253384 2843 717301 SGTC_2168 5727979 200 µM -0.243664907866042 0.401021141074246 no 2031 0.403745176870302 2784 695210 SGTC_1798 st045719 60.953 µM -0.244606038777488 0.400663570925291 no 2032 0.403380743908306 2836 3980186 SGTC_205 1486-1330 71.903 µM -0.245162682601344 0.400452120670172 no 2033 0.403165234867682 2826 4118834 SGTC_1886 st057356 49.9 µM -0.245252832448363 0.400417878520456 no 2034 0.403130335409752 2817 24207747 SGTC_1553 gossypol 38.6 µM -0.249635300521907 0.398754187555132 no 2035 0.401434698403172 2818 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1453 4237-0541 195 µM -0.249902971887022 0.398652632280562 no 2036 0.401331192449777 2978 739892 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.25252793220344 0.397657079520759 no 2037 0.400316513380578 3133 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_708 3448-5400 146 µM -0.252562991970487 0.39764378710977 no 2038 0.400302965554511 2908 3462195 SGTC_3132 9126706 49.47 µM -0.252877882310281 0.397524406254148 no 2039 0.400181290731169 3068 850858 SGTC_1809 st050081 57.6 µM -0.252889992408874 0.397519815279375 no 2040 0.400176611536467 3011 5036894 SGTC_2255 7941087 197.44 µM -0.253665285674654 0.397225928843605 no 2041 0.399877077508395 3013 935561 SGTC_1850 st056238 17 µM -0.255036169507216 0.396706417831934 no 2042 0.399347581730467 2815 5393177 SGTC_1685 st024049 53.0905 µM -0.257749117158976 0.395678858561778 no 2043 0.398300268219302 2951 1941139 SGTC_965 1291-5240 308 µM -0.259495987527176 0.395017594941708 no 2044 0.397626288755896 2986 2834598 SGTC_2189 6047310 154.431 µM -0.259965180065571 0.394840037324782 no 2045 0.397445316328652 2833 711535 SGTC_2749 bexarotene 57.39 µM -0.260147768573483 0.394770945834707 no 2046 0.397374896011961 2973 82146 An retinoic acid receptor inhibitor. SGTC_3039 9090270 49.47 µM -0.260164734677644 0.394764526029023 no 2047 0.397368352733654 2967 17173750 SGTC_2584 androsterone 48.74 µM -0.260209335912002 0.394747649500233 no 2048 0.397351151616116 3000 2754130 A steroid. SGTC_2130 NSC 7 2.4545 µM -0.260905201771017 0.394484368480077 no 2049 0.397082806657117 2990 21448 SGTC_975 1335-0046 28.5 µM -0.261438263550653 0.394282717015982 no 2050 0.396877276361807 2898 16486740 SGTC_2511 berberine 10.47 µM -0.261712685282096 0.394178917307956 no 2051 0.396771479941068 2873 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3079 9117512 49.47 µM -0.261917501116947 0.3941014508486 no 2052 0.396692523280428 2843 7185044 SGTC_220 paclitaxel 373.376 µM -0.262999430549149 0.393692307724759 no 2053 0.396275509012971 2980 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_87 0100-0052 35.5 µM -0.263248944102257 0.393597968154099 no 2054 0.396179354392068 2935 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2040 5100729 123 µM -0.263987550687857 0.39331874208294 no 2055 0.395894755846792 2869 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2762 leflunomide 42.06 µM -0.265628149056539 0.392698719555496 no 2056 0.395262802181493 2878 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1641 st009299 47.1 µM -0.265929307308645 0.392584933957915 no 2057 0.395146826772383 2893 4046054 SGTC_1643 st009866 20.2 µM -0.266039713988658 0.392543221676998 no 2058 0.395104311718351 2969 3156273 YOR207C RET1 SGTC_1771 st048882 4.1505 µM -0.267095921231619 0.392144242936478 no 2059 0.394697653969103 2862 4580403 SGTC_327 1273-0057 3.96 µM -0.267413447080433 0.392024320757416 no 2060 0.394575423523866 2919 3108138 SGTC_2105 5350118 200 µM -0.267556705451427 0.391970218736431 no 2061 0.394520280120656 2909 2133313 SGTC_478 N-arachidonylglycine 10 µM -0.26821806130065 0.39172048249881 no 2062 0.39426573663979 2943 5283389 SGTC_369 0957-0393 4.5 µM -0.268320178903128 0.391681925588901 no 2063 0.394226437508243 2934 6997992 SGTC_1793 st048256 72.231 µM -0.269563177039283 0.391212687722102 no 2064 0.393748166188475 2861 672022 SGTC_1109 tnp00067 928.257 nM -0.270009323053255 0.391044303992485 no 2065 0.393576540575998 2908 676295 SGTC_422 cantharidin 155 µM -0.271363491190192 0.390533341165349 no 2066 0.39305573934519 2842 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_216 k038-0035 28.382 µM -0.271759209765092 0.390384061907787 no 2067 0.392903585527693 2973 4444231 YPR107C YTH1 SGTC_2987 9018338 71.43 µM -0.272308526040649 0.390176866869722 no 2068 0.392692400509643 2895 5055682 SGTC_12 0849-0099 9.267 µM -0.273552980760239 0.389707590011079 no 2069 0.392214085971475 2931 6071388 SGTC_1567 st069303 68.4 µM -0.275868526703967 0.38883483897656 no 2070 0.391324524129884 2996 5581319 SGTC_468 gf-109203x 121 µM -0.276299494141371 0.38867246505933 no 2071 0.391159022208351 2970 2396 A protein kinase C inhibitor. SGTC_1805 st050013 60.3 µM -0.276665716772253 0.388534500074035 no 2072 0.391018399345456 2947 4037144 SGTC_3293 9120939 62.045 µM -0.276779878837568 0.388491495317214 no 2073 0.390974566090394 3045 934087 SGTC_395 anisomycin 6.25 µM -0.277116941634725 0.388364532013634 no 2074 0.3908451567572 2949 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1009 4106-0057 9.87 µM -0.277285383163873 0.388301088682302 no 2075 0.390780491122951 3029 2928005 SGTC_2747 doxorubicin 7.63 µM -0.278202228116826 0.387955812261342 no 2076 0.390428562281253 2920 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2575 plumbagin 510 nM -0.279152419320569 0.387598071360512 no 2077 0.390063928271267 2848 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2423 st077119 87.2 µM -0.279565422828706 0.38744260791392 no 2078 0.389905469119261 2871 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_418 lividomycin a 100 µM -0.279580469086123 0.387436944518013 no 2079 0.389899696590559 3013 72394 An antibiotic. SGTC_236 1509-0011 5.31 µM -0.279592836675167 0.387432289388078 no 2080 0.389894951756866 3002 3107280 SGTC_3344 9148862 3.898 µM -0.280413267514868 0.38712351742799 no 2081 0.389580229601574 3065 4905352 SGTC_2132 5317594 122.667 µM -0.280798820903281 0.386978437740456 no 2082 0.389432354019311 2880 794577 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.284528860908788 0.385575681017556 no 2083 0.388002559889337 2843 4000243 SGTC_3320 9137005 35.139 µM -0.284579811611951 0.385556530289934 no 2084 0.387983039989646 2945 4908713 SGTC_3057 9095946 49.47 µM -0.28630717014449 0.384907437228865 no 2085 0.387321433455322 2864 24540043 SGTC_3258 9138477 49.47 µM -0.286646128975875 0.384780103757486 no 2086 0.387191645022398 2935 4970355 SGTC_2157 5649910 96.377 µM -0.287606931109177 0.384419235849272 no 2087 0.386823819353363 2915 2858091 SGTC_2002 4023503 131 µM -0.288733102326 0.38399638442646 no 2088 0.386392814524551 3028 4736863 YCR052W RSC6 SGTC_625 k213-0058 121 µM -0.28906484450298 0.383871849161415 no 2089 0.386265877861486 2975 3655420 SGTC_605 1315-0399 119 µM -0.289075619663492 0.383867804391467 no 2090 0.386261755095888 3047 24020461 SGTC_3323 9138564 53.9225 µM -0.289943648798855 0.383542006001494 no 2091 0.38592967413275 3084 43912313 YNL103W MET4 SGTC_2956 9076196 2.52 µM -0.290002843975296 0.383519791202569 no 2092 0.385907030939582 3047 16423868 SGTC_98 0074-0023 107.663 µM -0.290643041824483 0.383279561873288 no 2093 0.385662168884008 2993 3563821 SGTC_1635 st007035 42.4 µM -0.290777748144445 0.383229020071918 no 2094 0.385610652381142 2966 3716403 SGTC_712 r015-0009 80.6 µM -0.292451063344704 0.382601358270883 no 2095 0.384970885432883 3023 6813872 YLR060W FRS1 SGTC_2316 5844804 197.44 µM -0.292722789617151 0.382499462589132 no 2096 0.384867024469153 3047 776813 SGTC_679 0422-0091 41.4 µM -0.292747308229602 0.382490268660204 no 2097 0.38485765321361 2921 627384 YHR062C RPP1 SGTC_2053 5265679 138 µM -0.292936347379427 0.382419385449609 no 2098 0.384785402844706 2902 764595 SGTC_417 st075190 100 µM -0.293471139066411 0.38221887821673 no 2099 0.38458102825393 3053 222757 SGTC_1829 berberine 14.4 µM -0.293496668307409 0.382209307433443 no 2100 0.384571272867694 3097 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1966 st070145 16.1 µM -0.294556155989381 0.381812174397842 no 2101 0.384166479631057 2861 3748532 SGTC_2792 7535235 81.82 µM -0.294759563894174 0.381735944217562 no 2102 0.384088779015143 3006 1281891 SGTC_1201 1889-3372 45.9 µM -0.294958806281475 0.381661279573918 no 2103 0.38401267411863 2954 5392199 SGTC_544 k015-0020 52.4 µM -0.295067910763605 0.381620395323734 no 2104 0.38397100122018 2963 3008304 SGTC_1853 st056710 91.2 µM -0.29761017346276 0.380668119034608 no 2105 0.383000354474824 3097 269167 SGTC_3245 9134821 49.47 µM -0.299405711856224 0.379995984409874 no 2106 0.382315252260504 2945 17014901 SGTC_375 3970-0961 9.27 µM -0.299827520872783 0.379838138596764 no 2107 0.382154360950181 2972 2898222 SGTC_2731 amoxapine 43.43 µM -0.299983008366129 0.379779958426331 no 2108 0.382095058229687 2986 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_166 k072-0058 166.424 µM -0.301786173046834 0.379105450968829 no 2109 0.381407536021933 3036 5846229 SGTC_1554 st069299 38.7 µM -0.30323788915036 0.378562676651452 no 2110 0.380854288069569 3017 24207999 SGTC_2886 9058944 51.95 µM -0.304290085465341 0.378169426254056 no 2111 0.380453448956696 2977 4949929 SGTC_354 2783-3500 4.88 µM -0.309702123324099 0.376148719931056 no 2112 0.37839374396845 2979 6740761 SGTC_2834 9001755 58.44 µM -0.310079166200733 0.376008068179116 no 2113 0.378250377471448 2997 2989575 SGTC_2245 6637752 200 µM -0.310627803670874 0.375803434349252 no 2114 0.3780417939194 3075 681890 SGTC_1468 k284-1086 134 µM -0.31107587776009 0.375636335110267 no 2115 0.377871469388543 2991 15996457 SGTC_2850 9015429 58.44 µM -0.312172165677006 0.375227597382734 no 2116 0.37745484220108 3012 6457570 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.31232941224739 0.375168981370069 no 2117 0.377395094765326 2953 4620898 SGTC_3159 9100096 49.47 µM -0.31237688040713 0.375151287469418 no 2118 0.377377059331158 2857 25236875 SGTC_340 k038-0059 454 µM -0.313235856066123 0.374831147109337 no 2119 0.377050739456079 2965 23733424 SGTC_588 3970-1144 52.9 µM -0.313503473226393 0.374731423761031 no 2120 0.3769490911736 3069 1888707 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.313791562610836 0.374624081120875 no 2121 0.376839676514596 2991 368090 SGTC_1198 1612-1005 86.7 µM -0.315213140184858 0.374094541064056 no 2122 0.376299914662335 3149 6998509 SGTC_2252 omeprazole 400 µM -0.315330519485481 0.374050827676445 no 2123 0.376255357456863 2981 4594 A proton pump inhibitor. SGTC_3208 9114115 49.47 µM -0.31692815169793 0.373456012511441 no 2124 0.375649060170348 3026 650895 SGTC_451 chloral hydrate 100 µM -0.318256530321888 0.372961672660376 no 2125 0.375145177546905 3088 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_604 1000-0114 314 µM -0.31866346394822 0.372810279091999 no 2126 0.374990861435876 3105 1572745 SGTC_359 0081-0058 15.9 µM -0.318745060013073 0.372779924860213 no 2127 0.374959921236186 3339 3494159 SGTC_1498 4478-3555 97.6 µM -0.319004804882808 0.372683303451412 no 2128 0.374861434613171 2975 3437919 SGTC_1292 0kpi-0043 232 µM -0.319637620594156 0.372447938521515 no 2129 0.374621526094661 3008 3333905 SGTC_1 0258-0098 57.368 µM -0.320223870476286 0.372229935449659 no 2130 0.374399314572299 3021 6790032 YDR047W HEM12 SGTC_2915 7971052 15.16 µM -0.325530028101274 0.370258656080088 no 2131 0.372389979985388 3040 5741558 SGTC_1919 st067113 52.3 µM -0.325668274352144 0.370207341770469 no 2132 0.37233767505782 3105 1268243 SGTC_2419 paclitaxel 166.5 µM -0.327291376524534 0.36960505092243 no 2133 0.371723757070032 2887 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_652 0437-0092 114 µM -0.327434960665287 0.369551785971377 no 2134 0.371669463850208 3005 3091274 SGTC_1171 0368-0077 21.4 µM -0.327464595004834 0.369540792926517 no 2135 0.371658258587002 2962 3239779 SGTC_3352 9151559 45.5865 µM -0.328863898798541 0.369021833927432 no 2136 0.371129281239688 3057 17159339 SGTC_3297 9117502 71.43 µM -0.329093723448746 0.368936621784895 no 2137 0.371042424111546 3062 7453720 SGTC_2037 5169046 200 µM -0.329146251361996 0.368917146901732 no 2138 0.371022573274141 3087 5718022 SGTC_550 4123-0385 25.7 µM -0.330964690741788 0.368243162796219 no 2139 0.370335578307492 2988 5731123 SGTC_1816 st051957 91.6 µM -0.332135823226969 0.367809310128965 no 2140 0.369893350511364 3011 674121 SGTC_85 0868-0259 160.055 µM -0.333430941043866 0.367329722726762 no 2141 0.369404505268206 3038 83173 SGTC_1415 3966-0071 78.1 µM -0.333762891671512 0.36720683333648 no 2142 0.369279243679866 3040 2893185 SGTC_1258 0671-0043 57.1 µM -0.334573587510171 0.366906767836655 no 2143 0.368973385914369 3041 4298767 SGTC_2357 9067248 200 µM -0.336567848521293 0.36616897180341 no 2144 0.368221348326507 3092 9150235 SGTC_780 0109-0199 192 µM -0.336850557677186 0.366064420790466 no 2145 0.368114779229644 3181 610414 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.337129000777339 0.365961457162629 no 2146 0.368009828170456 2945 6708630 An antioxidant. SGTC_24 0417-1663 219 µM -0.337460084170307 0.365839040592952 no 2147 0.367885048699769 3100 4329390 SGTC_152 4469-0003 551.229 µM -0.338016709840568 0.365633261589303 no 2148 0.36767529776315 2994 697280 SGTC_2207 7258803 200 µM -0.338879831144106 0.365314250656225 no 2149 0.367350129407719 3084 3666799 SGTC_202 3594-0513 34.79 µM -0.341210707367682 0.364453221366049 no 2150 0.366472481574977 3015 708429 SGTC_469 w7 172 µM -0.341474338043627 0.364355878729808 no 2151 0.366373260218888 3030 45115570 A P450 inhibitor. SGTC_3329 9141233 27.5565 µM -0.342439549652499 0.363999559982665 no 2152 0.366010064624052 3152 4909101 YNL103W MET4 SGTC_292 k038-0015 474 µM -0.343385741348913 0.363650376742339 no 2153 0.365654142455212 3126 46368540 SGTC_1451 4152-0210 104 µM -0.34524506038812 0.362964542450542 no 2154 0.36495507280221 3167 659563 SGTC_1877 wortmannin 25 µM -0.346636447446255 0.362451598237063 no 2155 0.364432230284532 3152 312145 A covalent inhibitor of PI 3-kinase. SGTC_2266 7929956 200 µM -0.348025791134949 0.361939653584012 no 2156 0.363910407158697 2970 2967153 SGTC_751 0833-0568 350 µM -0.348313791335473 0.361833562286181 no 2157 0.363802268796525 3120 6954252 SGTC_791 1348-1292 225 µM -0.348616147061066 0.361722194235005 no 2158 0.36368875189141 3076 5437054 SGTC_2083 5306046 65.942 µM -0.349044817715525 0.3615643201085 no 2159 0.363527831621203 3038 539837 SGTC_3120 9124077 49.47 µM -0.349608412860476 0.361356790812987 no 2160 0.363316298184588 3049 18774327 YGL155W CDC43 SGTC_2076 5212012 200 µM -0.352898828870272 0.360145996439219 no 2161 0.362082144423178 3020 604802 SGTC_2738 aclarubicin 5.55 µM -0.353374943750574 0.359970913346268 no 2162 0.361903683832099 3076 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1720 st037298 9.481 µM -0.354078175696597 0.359712365584683 no 2163 0.361640148621906 3126 597396 SGTC_2113 5491891 107.031 µM -0.357105959807447 0.358599915704684 no 2164 0.360506241488263 3051 789979 SGTC_2222 6885208 172.143 µM -0.358992295719096 0.35790745509349 no 2165 0.359800426389157 3070 609514 SGTC_2344 7990960 76.95 µM -0.359364272240272 0.357770960223449 no 2166 0.359661299320422 3048 140813 SGTC_3108 9121785 49.47 µM -0.359706141793623 0.357645528986551 no 2167 0.359533449292343 2998 17140271 SGTC_2761 levamisole 97.89 µM -0.360147301813926 0.357483691000995 no 2168 0.359368490532113 3193 26879 An alkaline phosphatase inhibitor. SGTC_1410 3909-8106 77.9 µM -0.362086760400658 0.356772511822491 no 2169 0.358643598509432 3134 1039210 SGTC_2273 7815444 169.05 µM -0.362545844566764 0.356604243195357 no 2170 0.358472085611682 3203 2824616 SGTC_2866 9034245 58.44 µM -0.362670434920374 0.356558581768134 no 2171 0.358425543835618 3088 6462273 SGTC_47 0149-0135 24.25 µM -0.36512258158225 0.355660307626829 no 2172 0.357509952592903 3039 5239155 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.365889188948731 0.355379646947293 no 2173 0.357223881907602 3075 6857784 SGTC_2612 dictamnine 15.46 µM -0.368653073026203 0.354368420305695 no 2174 0.356193165486937 3123 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3174 9107204 49.47 µM -0.368721123002906 0.354343535663936 no 2175 0.356167801286068 3182 3938802 SGTC_3152 9099253 49.47 µM -0.368927619389742 0.354268027488909 no 2176 0.356090837987061 3109 25236131 SGTC_3216 9129716 49.47 µM -0.368948913121364 0.354260241475961 no 2177 0.356082901930604 3066 8056934 SGTC_594 1487-1584 10.8 µM -0.369197108125331 0.354169493933192 no 2178 0.355990405619432 3064 5013332 SGTC_413 propylparaben 100 µM -0.37027611376918 0.353775073400321 no 2179 0.355588384734413 3039 7175 A pharmaceutical preservative. SGTC_2650 prasterone 100 µM -0.370813480758871 0.353578702367926 no 2180 0.355388229947584 3115 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1329 1447-1697 50.6 µM -0.373258746268664 0.352685617093061 no 2181 0.354477938512806 3149 2840515 SGTC_1000 4048-0884 8.67 µM -0.37524590435394 0.351960443811349 no 2182 0.353738796757517 3184 13040088 SGTC_1998 st075797 76.8 µM -0.376254933000188 0.351592424974243 no 2183 0.353363690007386 3185 24208315 SGTC_1132 3456-3614 2.5 µM -0.376597522366488 0.351467505376828 no 2184 0.353236364652842 3293 3125502 SGTC_2421 5690543 90.72 µM -0.377512587800383 0.351133920438262 no 2185 0.352896355766096 3166 3397993 SGTC_2224 6650123 117.647 µM -0.377516246281317 0.351132586977683 no 2186 0.35289499662777 3103 2908370 SGTC_2261 9010538 184.68 µM -0.377967517954325 0.350968119387774 no 2187 0.352727362040941 3158 6457250 SGTC_1321 1326-2144 215 µM -0.378594514294359 0.350739654652428 no 2188 0.352494498203861 3170 3513030 SGTC_1023 4482-3888 16 µM -0.382233855743575 0.34941462051824 no 2189 0.351143955839098 3244 3303168 SGTC_3305 9127027 53.8275 µM -0.382787688380507 0.349213137975798 no 2190 0.350938595384091 3089 41905295 SGTC_1039 k821-0043 94 µM -0.382957719979749 0.349151289546046 no 2191 0.350875556609319 3209 15992768 SGTC_1261 0712-0010 12.7 µM -0.383696800887596 0.348882497893049 no 2192 0.350601591995633 3255 2840123 SGTC_3074 9116018 49.47 µM -0.385760988356165 0.348132188577604 no 2193 0.349836844961634 3050 17027303 SGTC_360 0957-0399 1.01 µM -0.389129817741937 0.346908933339352 no 2194 0.348590058493617 3215 6752301 YPR165W RHO1 SGTC_857 0438-0306 1.35 µM -0.390644801032251 0.346359346698083 no 2195 0.348029902661265 3185 4686136 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.391556220684089 0.34602886899164 no 2196 0.347693070397256 3211 61125 An anti-inflammatory. SGTC_564 3555-0129 330 µM -0.391853341347359 0.345921159363833 no 2197 0.347583289835976 3141 563260 SGTC_898 1000-0849 28.3 µM -0.392562079870645 0.345664283919089 no 2198 0.347321475747224 3172 6751807 SGTC_3247 9135149 49.47 µM -0.393983004039888 0.345149497740639 no 2199 0.346796793670055 3112 8934436 YOR116C RPO31 SGTC_3301 9125354 19.7965 µM -0.394014108588679 0.345138232083334 no 2200 0.346785311468938 3087 41905162 SGTC_2995 9067767 71.4286 µM -0.394385289617629 0.345003805803738 no 2201 0.346648301367969 3153 11673567 SGTC_1120 ficusin 1.78878 µM -0.395881464210211 0.344462152266928 no 2202 0.346096237880438 3229 6199 A DNA cross-linker. SGTC_392 N-ethylmaleimide 8.33 µM -0.396057967196536 0.344398274665266 no 2203 0.346031132756572 3110 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1408 3909-7976 48.8 µM -0.398591353538804 0.343481915116639 no 2204 0.34509716682597 3150 24152374 SGTC_88 0180-0332 8.668 µM -0.399021812752214 0.34332630350604 no 2205 0.344938565972266 3088 3101745 SGTC_2673 kobusone 100 µM -0.400191479164335 0.342903601642663 no 2206 0.344507745031794 3131 6710676 An epoxy ketone and protein crosslinker. SGTC_1351 1496-0003 46.5 µM -0.400518912399229 0.342785306824148 no 2207 0.344387178287635 3243 3891978 SGTC_862 0452-0056 10.2 µM -0.401557446648291 0.342410208014452 no 2208 0.344004876146829 3182 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_634 1611-4317 11.2 µM -0.402354683606625 0.342122366597771 no 2209 0.343711507777406 3243 2843522 SGTC_1940 st075990 51.1 µM -0.403229607622155 0.341806581922514 no 2210 0.343389660310843 3357 1084979 SGTC_1481 3346-2004 36 µM -0.403800252681069 0.341600679684526 no 2211 0.343179805333248 3207 2770522 SGTC_1784 st039334 36.3 µM -0.404080412891095 0.341499608496295 no 2212 0.343076793982249 3329 3496984 SGTC_2826 7992541 19.48 µM -0.404145911977612 0.341475980546578 no 2213 0.343052712481575 3122 2985066 SGTC_2569 tetrandrine 100 µM -0.404577952986354 0.341320142899607 no 2214 0.342893883555642 3143 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2885 9057732 51.95 µM -0.405901660998133 0.340842848552616 no 2215 0.342407428783041 3247 6471414 SGTC_1548 st061468 90.8 µM -0.406548397252126 0.340609744998805 no 2216 0.342169852056133 3222 390799 SGTC_278 4092-0821 23.9 µM -0.408174097770086 0.340024061695621 no 2217 0.34157293159606 3202 877900 SGTC_3214 9129694 49.47 µM -0.409219937583999 0.339647485875291 no 2218 0.341189132090987 3268 17158655 SGTC_387 norethindrone acetate 66.7 µM -0.409438679751486 0.339568743545919 no 2219 0.341108879428209 3147 541197 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.409647722314193 0.339493499402611 no 2220 0.341032192096415 3248 5282362 SGTC_347 4534-1311 26.2 µM -0.413647155621597 0.33805515247036 no 2221 0.339566266595587 3135 2862016 SGTC_232 clozapine 119 µM -0.41418139132577 0.337863199470177 no 2222 0.33937063445164 3166 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1420 4'-methoxyflavone 42 µM -0.414467116628804 0.337760554539415 no 2223 0.339266022266182 3218 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_962 1254-0300 21.5 µM -0.416255093697157 0.337118509817356 no 2224 0.338611674434317 3105 7340576 SGTC_1736 st036774 51 µM -0.417023478470145 0.336842736069624 no 2225 0.338330617316961 3349 1272247 SGTC_1406 3909-7906 11.9 µM -0.41704473481271 0.336835108401604 no 2226 0.338322843525023 3187 X1406 SGTC_1523 st012844 44.7 µM -0.418550084538213 0.336295096552256 no 2227 0.337772487945789 3272 4274103 SGTC_3302 9125395 16.351 µM -0.418805917735331 0.336203355423706 no 2228 0.337678989810881 3158 17599668 SGTC_401 neomycin 50 µM -0.418841497482261 0.336190597390162 no 2229 0.337665987444279 3176 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1243 0416-0003 5.65 µM -0.4197450778724 0.335866658669088 no 2230 0.337335845369764 3144 2141977 SGTC_1630 st005209 31.3 µM -0.420027491193972 0.335765436875886 no 2231 0.337232685399238 3278 3367314 SGTC_1295 1013-0063 9.78 µM -0.4206278806719 0.335550286551931 no 2232 0.337013415728145 3276 6826038 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.421488291187741 0.335242051358645 no 2233 0.336699279699322 3277 5377381 SGTC_253 dyclonine 31.25 µM -0.422600602038493 0.334843739248899 no 2234 0.336293343645312 3209 3180 An oral anasthetic. SGTC_222 nsc-310342 10.666 µM -0.422610675175325 0.334840132964559 no 2235 0.336289668341259 3238 432556 SGTC_2171 5739187 198.077 µM -0.423326439834178 0.334583921024587 no 2236 0.33602855314547 3060 2262761 SGTC_1306 1185-0270 9.02 µM -0.423563822291875 0.334498965653244 no 2237 0.335941972078854 3249 1548076 SGTC_1624 st003710 6.25 µM -0.425859437128936 0.333677839717743 no 2238 0.335105136766168 3255 24207033 SGTC_56 0957-0365 83.25 µM -0.426808558800881 0.333338577656789 no 2239 0.334759386030511 3254 6752360 SGTC_802 4112-3352 742 µM -0.426912634468752 0.333301384259017 no 2240 0.334721481346535 3287 704594 SGTC_1734 st037168 69.4 µM -0.427222824041384 0.333190541903638 no 2241 0.334608519324275 3220 708907 SGTC_144 4161-2749 112.381 µM -0.427903067329096 0.332947516508056 no 2242 0.334360846919363 3184 797501 YMR168C CEP3 SGTC_2150 5556613 200 µM -0.428235597398504 0.332828741516951 no 2243 0.334239800987385 3167 743190 SGTC_1683 st010134 710 nM -0.428335017053664 0.332793233492875 no 2244 0.334203614088415 3113 3818134 SGTC_3195 9113082 49.47 µM -0.429162273812007 0.332497834473672 no 2245 0.333902567852857 3258 17018038 SGTC_2489 cantharidin 73.42 µM -0.429497980730329 0.332377989017472 no 2246 0.333780431533063 3215 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1559 coumarin 343 70.1 µM -0.432281066863127 0.331385103993261 no 2247 0.332768573027137 3307 108770 A hepatotoxic, DNA x-linker. SGTC_2585 alliin 100 µM -0.432395193131981 0.331344413890219 no 2248 0.332727105576645 3365 87310 A garlic compound which reacts with lipids. SGTC_168 3970-0862 530.542 µM -0.433415292366111 0.330980800449096 no 2249 0.332356546402279 3252 3135186 SGTC_1216 1165-0504 9.65 µM -0.433433674967173 0.330974249448556 no 2250 0.332349870277488 3282 6304004 SGTC_2636 apigenin dimethyl ether 100 µM -0.433789669093008 0.330847394164883 no 2251 0.332220592144675 3309 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3010 9080089 71.4286 µM -0.436569940410868 0.329857338751862 no 2252 0.331211633258164 3255 17027233 SGTC_259 usnic acid 108.925 µM -0.436872309095718 0.329749736848642 no 2253 0.331101977512135 3355 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2007 4011539 71.82 µM -0.436987564881591 0.329708725258261 no 2254 0.331060183149516 3148 45595301 SGTC_3190 9110366 49.47 µM -0.43817779581821 0.329285323927317 no 2255 0.330628701600433 3259 17123768 SGTC_3099 9120367 49.47 µM -0.438237073095148 0.329264242914119 no 2256 0.330607218327415 3182 24824940 SGTC_3102 9121669 49.47 µM -0.439406086758378 0.328848612926601 no 2257 0.330183658454432 3181 41905072 SGTC_1062 mesoridazine 14.2 µM -0.440313354835353 0.328526189491613 no 2258 0.329855084768502 3214 4078 A neuroleptic. SGTC_689 0833-0039 98 µM -0.441196281473716 0.32821253901286 no 2259 0.329535452507486 3227 5374726 SGTC_2411 st077133 39.94 µM -0.44307561901648 0.327545327274276 no 2260 0.328855519773949 3419 1403142 YNL221C POP1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.443199805194955 0.327501257444691 no 2261 0.328810609893314 3183 91467 include heat shock SGTC_1480 1070-0044 41.2 µM -0.443576706087492 0.327367521706465 no 2262 0.32867432504643 3248 3124987 SGTC_3029 9088683 49.47 µM -0.444314303501792 0.327105864138864 no 2263 0.328407680679989 3298 25236615 SGTC_2993 9054257 71.4286 µM -0.444673228334837 0.326978568764581 no 2264 0.32827795953651 3170 6470217 YGL055W OLE1 SGTC_2622 2-methoxyxanthone 59.94 µM -0.445594801807189 0.326651818068344 no 2265 0.327944983076134 3187 71034 A hepatoprotective. SGTC_1779 st039427 55 µM -0.445687898910261 0.326618817189518 no 2266 0.327911353482998 3376 1124498 SGTC_342 k048-0088 23.3 µM -0.447214828578437 0.326077747908432 no 2267 0.327359977895328 3167 6820570 SGTC_2857 9024691 58.44 µM -0.449280534164695 0.325346345305849 no 2268 0.326614649091758 3263 16478292 SGTC_2794 7785382 27.27 µM -0.449731244255302 0.325186852007362 no 2269 0.326452119838435 3300 2205081 SGTC_1992 st073643 23.3 µM -0.450291890589545 0.324988500135146 no 2270 0.326249992772803 3173 3161292 SGTC_568 1193-0097 7.48 µM -0.451138560389282 0.324689049625411 no 2271 0.325944843795489 3247 3646150 SGTC_3007 9078383 71.4286 µM -0.451736045575213 0.324477798988911 no 2272 0.325729573780084 3196 6496995 SGTC_1883 5-benzylidenerhodanine 20 µM -0.45430236344453 0.32357107827529 no 2273 0.324805607605169 3289 1273210 SGTC_2777 climbazole 1.536 µM -0.454827140982535 0.323385794768131 no 2274 0.324616801359059 3277 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2933 9026794 32.47 µM -0.455370603347528 0.323193960354247 no 2275 0.324421320117477 3202 17586027 SGTC_3262 9137218 49.47 µM -0.456219491310463 0.32289440915979 no 2276 0.324116075312339 3210 17650664 SGTC_1955 wogonin 32.4 µM -0.458716255550901 0.322014030201316 no 2277 0.323218969603237 3404 5281703 A flavanone. SGTC_612 0302-0167 22.4 µM -0.458917713485516 0.32194303797326 no 2278 0.323146629001028 3262 235821 SGTC_1056 3448-1962 115 µM -0.459269389934135 0.321819125468666 no 2279 0.32302036315278 3284 715507 SGTC_1405 3909-7894 12 µM -0.459551917723673 0.32171959170971 no 2280 0.322918939197813 3295 7104060 SGTC_3192 9110362 49.47 µM -0.460767336618842 0.321291548970159 no 2281 0.322482769212003 3317 16649480 SGTC_3340 9146634 11.102 µM -0.461929677769576 0.320882420921175 no 2282 0.322065875340952 3304 4907387 SGTC_3178 9107506 49.47 µM -0.462263045437635 0.320765120199228 no 2283 0.321946348503345 3337 8897194 SGTC_1483 3453-0561 55.9 µM -0.462566234148478 0.320658453959657 no 2284 0.321837658129411 3293 4546991 SGTC_2013 4024628 200 µM -0.462788467881186 0.320580278273764 no 2285 0.321757999053469 3338 5230760 SGTC_866 0495-0101 262 µM -0.463141064781556 0.320456260759123 no 2286 0.321631628466774 3209 635694 SGTC_1068 loratadine 26.9 µM -0.463330640421988 0.320389590353293 no 2287 0.32156369316275 3239 3957 A H1 histamine antagonist. SGTC_35 0133-0054 64.071 µM -0.463751479398348 0.320241609433281 no 2288 0.321412904905107 3238 99677 SGTC_112 phenothiazine 287.218 µM -0.466379930747784 0.319318006458607 no 2289 0.32047178712424 3353 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3328 9140624 29.0385 µM -0.466484859221976 0.319281159195734 no 2290 0.320434241351436 3331 4904392 SGTC_228 caffeine 993.056 µM -0.466533794978055 0.319263975255502 no 2291 0.320416731663431 3314 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1820 st053765 18.6 µM -0.469526301032981 0.318213886611655 no 2292 0.319346744882317 3288 3690829 SGTC_1875 nocodazole 6 µM -0.471224955166046 0.317618467180058 no 2293 0.318740049825368 3353 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_552 k242-0005 476 µM -0.471630503606623 0.317476382281802 no 2294 0.318595274981487 3345 4088318 SGTC_1377 2944-0135 198 µM -0.471773049139041 0.317426447487316 no 2295 0.318544394893027 3288 1894137 SGTC_1361 1608-0041 5.61 µM -0.472508924487987 0.317168717566287 no 2296 0.318281786575508 3240 X1361 SGTC_897 1000-0139 31.4 µM -0.472765649937806 0.317078823965213 no 2297 0.3181901916669 3360 6151020 SGTC_635 k038-0028 24.7 µM -0.473298830416338 0.316892162851893 no 2298 0.317999998222392 3248 4035102 SGTC_734 2023-0417 80 µM -0.473936873926374 0.316668851495278 no 2299 0.31777246164681 3301 3935732 SGTC_2596 sinensetin 100 µM -0.474172904084009 0.316586259293894 no 2300 0.317688306925112 3234 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1596 piperlongumine 63 µM -0.474472590914147 0.316481405383473 no 2301 0.317581469481642 3362 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2298 7976326 193.81 µM -0.476323622878146 0.315834096661568 no 2302 0.316921919169735 3255 2235818 SGTC_1837 st055472 66.5 µM -0.476464191875547 0.31578496250063 no 2303 0.316871856063135 3413 676091 SGTC_1896 st058441 89 µM -0.477036917711512 0.315584806898376 no 2304 0.316667916632434 3251 688759 SGTC_941 3237-0776 460 µM -0.477810136538083 0.315314669030737 no 2305 0.316392672920236 3380 760008 SGTC_879 0831-1030 162 µM -0.479041511413238 0.314884669924993 no 2306 0.315954548737533 3303 1549252 SGTC_598 3937-0236 20.2 µM -0.479041848407185 0.314884552280192 no 2307 0.315954428870153 3313 1379313 SGTC_2026 5148700 152 µM -0.479932141128848 0.3145738161306 no 2308 0.31563782294517 3231 79838 SGTC_2824 7998404 51.95 µM -0.481144704602787 0.314150810010134 no 2309 0.315206828671945 3211 837851 SGTC_522 1273-0010 11.6 µM -0.481146329341612 0.314150243379085 no 2310 0.315206251342352 3421 5705015 SGTC_52 0329-0193 875 nM -0.482027813522564 0.313842888554943 no 2311 0.314893094097434 3429 3739292 SGTC_1844 rapamycin 4 nM -0.482083088504548 0.313823619642316 no 2312 0.31487346146428 3254 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_170 4197-0004 226 µM -0.48233712458401 0.313735068947166 no 2313 0.314783239358396 3361 218692 SGTC_163 TUB2.036 7.546 µM -0.483702852186894 0.313259194073738 no 2314 0.314298384366414 3336 15992207 YJR013W GPI14 SGTC_2090 5301565 104.445 µM -0.483856756722252 0.313205586963732 no 2315 0.314243765873342 3267 2056344 SGTC_783 0848-0141 92.7 µM -0.485628921061499 0.312588601889923 no 2316 0.313615143682428 3306 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3180 9109287 49.47 µM -0.486603920446137 0.312249376215295 no 2317 0.313269522374768 3344 18891271 SGTC_2084 5306078 60.6385 µM -0.486751135465467 0.312198170396328 no 2318 0.31321735130133 3243 679340 SGTC_306 1672-3436 11.6 µM -0.488258041129315 0.311674231964529 no 2319 0.312683538813512 3352 6797378 SGTC_2409 alverine citrate 63.97 µM -0.490145520739867 0.3110185087123 no 2320 0.312015464215246 3438 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3255 9139072 49.47 µM -0.491024574280806 0.31071332401716 no 2321 0.311704533407295 3344 17646060 SGTC_2591 skatole 100 µM -0.492230334673809 0.31029492692535 no 2322 0.311278261116519 3353 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3266 9136860 49.47 µM -0.492617396349595 0.310160669096822 no 2323 0.31114147686478 3330 4871271 YPR165W RHO1 SGTC_3068 9116768 49.47 µM -0.492807790380793 0.310094637511018 no 2324 0.311074202827323 3346 41904888 SGTC_1246 0422-0085 105 µM -0.494556504154389 0.309488443239983 no 2325 0.31045660582229 3396 264295 SGTC_946 3434-1334 87.4 µM -0.496355351506835 0.308865410508266 no 2326 0.30982186011618 3345 4047976 SGTC_581 0958-0271 211 µM -0.498177499813037 0.30823486770323 no 2327 0.30917946993007 3301 4591145 SGTC_716 1683-5115 658 µM -0.499602477681538 0.307742157058949 no 2328 0.30867750645686 3392 723597 SGTC_1259 0671-0132 43 µM -0.500258033638382 0.307515603613684 no 2329 0.308446699889777 3240 X1259 SGTC_2 0422-0095 29 µM -0.501251280684137 0.307172487452149 no 2330 0.308097144076686 3286 6790840 SGTC_1127 asiatic acid 681.4 nM -0.50147828332651 0.307094093305464 no 2331 0.308017278909652 3248 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_40 0327-0103 19.753 µM -0.50272395508816 0.306664064250296 no 2332 0.307579182551281 3252 409036 SGTC_2836 9010338 19.48 µM -0.503056991888197 0.306549138794986 no 2333 0.307462101663595 3261 2994051 SGTC_3035 9091303 49.47 µM -0.503315962316461 0.306459785556947 no 2334 0.307371072764558 3361 25237002 SGTC_1098 clofazimine 15.1 µM -0.503508108631861 0.306393496250787 no 2335 0.307303540412818 3407 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2922 7999257 32.47 µM -0.50676773264354 0.305269912680195 no 2336 0.306158899662608 3372 2988377 SGTC_2272 7805186 180 µM -0.507111333293298 0.305151581045465 no 2337 0.306038351700536 3397 2956062 YPR165W RHO1 SGTC_370 0180-0345 38.7 µM -0.508640506582584 0.30462520060865 no 2338 0.305502115383435 3250 3989527 SGTC_2767 sibutramine 71.45 µM -0.50905919389585 0.304481148214242 no 2339 0.305355366661636 3464 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2429 5902844 64.44 µM -0.50959432734665 0.304297075831999 no 2340 0.305167849430618 3364 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_64 000l-0018 272.079 µM -0.509595905650947 0.304296533008509 no 2341 0.305167296449312 3333 6811119 SGTC_546 peri-Naphthalide 147 µM -0.509635387001109 0.30428295439579 no 2342 0.30515346374279 3293 223824 A penicillin ester. SGTC_1025 k007-0731 70 µM -0.511094001362836 0.303781490110389 no 2343 0.304642618068441 3257 6256118 SGTC_1920 st075728 45.7 µM -0.512455553266905 0.303313728441884 no 2344 0.304166109772771 3440 3400306 SGTC_1546 5-methoxyflavanone 78.7 µM -0.512999149081305 0.303127065859065 no 2345 0.303975957959209 3379 147795 SGTC_958 1222-0007 33 µM -0.514796984203612 0.302510082769769 no 2346 0.303347446496254 3447 7312461 SGTC_771 0250-0039 27.3 µM -0.515185605551905 0.30237678929042 no 2347 0.303211663374873 3285 3005115 SGTC_467 ro 31-8220 72.8 µM -0.51592044650606 0.302124817760575 no 2348 0.302954986479922 3299 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_990 3985-0011 41.3 µM -0.519604961304965 0.300862848705874 no 2349 0.301669469711714 3316 5399565 YGL099W LSG1 SGTC_1089 terbinafine 2.25 µM -0.520278076890598 0.30063255954775 no 2350 0.30143488683996 3401 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_989 1501-0895 10.3 µM -0.520680121095768 0.30049504844839 no 2351 0.301294812362736 3425 2830112 SGTC_2030 5175110 200 µM -0.520703060736428 0.300487203264421 no 2352 0.301286820946081 3435 2831986 SGTC_1412 3909-8563 178 µM -0.52164079105891 0.300166585788606 no 2353 0.300960228269552 3440 23767530 SGTC_3252 9135871 49.47 µM -0.522073720163161 0.300018616089224 no 2354 0.300809501617266 3427 17682838 SGTC_455 paf C-16 10 µM -0.522170604199148 0.299985506869147 no 2355 0.300775775570212 3345 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_793 0488-0545 106 µM -0.52230315111894 0.299940212867972 no 2356 0.300729637774281 3284 292548 SGTC_10 0279-0212 42.575 µM -0.524660087915599 0.299135316620046 no 2357 0.299909753760876 3376 39851 YBR002C RER2 SGTC_714 4296-0578 26.1 µM -0.525110963781371 0.298981453847079 no 2358 0.299753027438848 3335 1589775 SGTC_1970 st070122 35.8 µM -0.525755486373653 0.298761570969358 no 2359 0.299529053143359 3465 102928 SGTC_351 caspofungin 25 nM -0.526608908234289 0.298470533961739 no 2360 0.299232602251436 3356 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1273 0849-0096 14.1 µM -0.526861279508523 0.298384494117716 no 2361 0.299144962222138 3369 5286025 SGTC_1194 1488-0194 225 µM -0.527769794386696 0.298074851588375 no 2362 0.298829562160943 3310 1391452 SGTC_2608 thymoquinone 42.66 µM -0.527819979262013 0.298057751709629 no 2363 0.29881214438243 3400 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2529 gangaleoidin 93.61 µM -0.528412922037264 0.297855747605987 no 2364 0.298606385325554 3316 4565183 SGTC_2346 9031566 143.75 µM -0.528713716672056 0.297753296581575 no 2365 0.298502030212828 3327 4771086 SGTC_984 1492-0255 2.91 µM -0.52960924240652 0.29744837462614 no 2366 0.298191442464225 3379 1585198 SGTC_2953 9074162 66.49 µM -0.529665822983876 0.297429114017979 no 2367 0.298171824037203 3389 16451992 SGTC_2943 9068529 45.32 µM -0.530354159291789 0.297194842917349 no 2368 0.297933201324809 3426 3270634 SGTC_67 0335-0847 266 µM -0.531217718692446 0.296901055041982 no 2369 0.297633957929389 3529 4552207 YOR254C SEC63 SGTC_2793 7325131 81.82 µM -0.531741740576792 0.296722844594783 no 2370 0.297452439070406 3329 4176441 SGTC_269 exalamide 29 µM -0.533280989231015 0.296199657172505 no 2371 0.296919542737079 3334 3316 A derivative of salicylamide. SGTC_2897 9048598 12.99 µM -0.533328990210892 0.296183348545259 no 2372 0.296902931560021 3314 6467404 SGTC_666 0272-0154 136 µM -0.533923877915303 0.295981265997288 no 2373 0.29669710054302 3366 6870312 SGTC_323 4013-0906 34.3 µM -0.534653058096139 0.295733650859453 no 2374 0.296444893529992 3419 2910086 SGTC_3022 9087993 49.47 µM -0.535735421463799 0.295366277324482 no 2375 0.29607070968998 3422 17173644 SGTC_3326 9140064 16.379 µM -0.536198546220809 0.295209148647022 no 2376 0.295910669074797 3330 1868434 SGTC_1503 4585-0012 61.3 µM -0.53698458072519 0.294942551470223 no 2377 0.295639132488721 3457 2922052 SGTC_3234 9132280 49.47 µM -0.538984018916859 0.294264907993799 no 2378 0.294948940839913 3423 17612295 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.541398070759132 0.293447704569335 no 2379 0.294116618336948 3344 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2656 pseudo-anisatin 100 µM -0.541847709723033 0.293295609266862 no 2380 0.293961710747575 3389 6708809 A neurotoxin. SGTC_223 busulfan 5 mM -0.544220868307102 0.292493468368548 no 2381 0.293144746556171 3432 2478 A DNA alkylator. SGTC_1832 st054113 55 µM -0.545073913859105 0.292205383529628 no 2382 0.292851341527946 3437 1251267 SGTC_2806 7952793 58.44 µM -0.545991836579962 0.291895536342956 no 2383 0.292535774348894 3422 2972490 SGTC_1317 1273-0028 910 nM -0.546023462170942 0.291884863770488 no 2384 0.29252490479213 3356 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_686 1319-0111 510 µM -0.546508694039439 0.291721137139715 no 2385 0.292358156573487 3498 4562600 SGTC_2710 st078562 53.7235 µM -0.548586526456786 0.29102052075551 no 2386 0.291644617163328 3382 17250908 SGTC_2582 agaric acid 100 µM -0.548647471834404 0.290999982688118 no 2387 0.291623700436304 3423 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_315 k915-0449 187 µM -0.548755459208411 0.290963593536128 no 2388 0.291586640402602 3419 20970215 YNL149C PGA2 SGTC_307 1501-1223 22.3 µM -0.551346594940354 0.290091081320942 no 2389 0.290698051438847 3429 2830329 SGTC_2461 5755302 26.15 µM -0.552212756338158 0.289799692811195 no 2390 0.290401297797959 3460 2788904 SGTC_179 1273-0063 6.77 µM -0.552365667457759 0.289748265688766 no 2391 0.290348923990208 3334 3108139 SGTC_2760 etidronate 98.04 µM -0.552853796870678 0.2895841264909 no 2392 0.290181763685076 3370 3305 A chelator and antioxidant. SGTC_503 tyrphostin 8 294 µM -0.552915575993688 0.289563355654177 no 2393 0.290160610590289 3445 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2287 7945887 168.79 µM -0.553535753673234 0.28935488370387 no 2394 0.289948302568223 3415 1245853 SGTC_501 nsc-95397 161 µM -0.553646114982082 0.289317793280796 no 2395 0.289910529755102 3481 262093 SGTC_439 amiodarone 34.4 µM -0.553769021414353 0.289276489300344 no 2396 0.289868465901676 3316 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.554975544186616 0.288871172031408 no 2397 0.28945569411304 3380 688667 SGTC_1356 1502-0781 85.8 µM -0.556805132450776 0.288257053647117 no 2398 0.288830288409655 3383 567702 SGTC_2848 9016370 25.97 µM -0.557023791430431 0.288183699931341 no 2399 0.288755587075504 3501 7894410 SGTC_1681 tripelennamine 100 µM -0.557612646207702 0.287986200115799 no 2400 0.28855445953163 3459 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1781 st038725 66.3 µM -0.55875587745445 0.287602946939217 no 2401 0.288164169336238 3365 4270275 YIL048W NEO1 SGTC_57 miconazole 162.5 nM -0.558832967909474 0.287577112061386 no 2402 0.288137860224419 3416 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_336 4111-0029 111 µM -0.559861474386748 0.287232539641843 no 2403 0.287786964258385 3397 3131175 SGTC_2294 7971431 200 µM -0.559998013344135 0.287186810767197 no 2404 0.28774039639002 3411 5741572 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.561139368719948 0.286804689190799 no 2405 0.287351265968126 3487 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2011 4012611 177 µM -0.562599644559218 0.286316145907627 no 2406 0.286853767059633 3394 2049887 SGTC_1141 3253-0389 52.6 µM -0.562883567634167 0.286221203783096 no 2407 0.286757085204359 3450 5402031 SGTC_2172 5754775 163.918 µM -0.563540042022162 0.286001740066931 no 2408 0.286533600859547 3354 2263357 SGTC_204 PMA1.184 62.41 µM -0.564302840281077 0.285746832077672 no 2409 0.286274024388426 3439 2252213 YGL008C PMA1 SGTC_2822 7994718 71.43 µM -0.565482111702514 0.285352962050575 no 2410 0.285872944046997 3425 1018011 SGTC_2136 5328288 199.296 µM -0.56575780757625 0.285260918485024 no 2411 0.285779216058615 3386 262395 SGTC_3042 9091578 49.47 µM -0.56590672117168 0.285211208216268 no 2412 0.285728596166099 3444 25236497 SGTC_3237 9133362 49.47 µM -0.566108883044815 0.285143729238343 no 2413 0.285659882522365 3442 43845137 SGTC_1476 4112-3294 3.34 µM -0.566611816822461 0.284975889570102 no 2414 0.285488972378606 3492 704369 SGTC_709 3807-1509 243 µM -0.56661532152371 0.284974720142285 no 2415 0.285487781559636 3487 1886677 YPL242C IQG1 SGTC_1954 st077032 68.9 µM -0.566809545801762 0.284909916121236 no 2416 0.285421792198228 3417 698907 SGTC_3058 9093861 49.47 µM -0.567031544755557 0.284835853533935 no 2417 0.285346375049769 3510 17217477 SGTC_509 pifithrin 175 µM -0.57032530377818 0.28373808072136 no 2418 0.284228540855074 3521 4817 A p53 inhibitor. SGTC_2216 7189485 200 µM -0.570708755665293 0.283610412304101 no 2419 0.284098541332536 3475 731273 SGTC_2490 carminic acid 95.39 µM -0.571312356954368 0.283409502001827 no 2420 0.283893963440852 3457 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1644 st010134 20.9 µM -0.571437234695744 0.283367944631665 no 2421 0.283851647575744 3472 3818134 SGTC_1285 0929-0069 65.5 µM -0.571443074336376 0.283366001361595 no 2422 0.283849668838668 3422 1206237 SGTC_2705 st078069 42.8 µM -0.57161018933307 0.283310392844195 no 2423 0.283793045440274 3426 1530061 SGTC_2652 actinonin 100 µM -0.573390218795213 0.282718402340776 no 2424 0.283190255769537 3443 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1852 st056254 31.4 µM -0.573411518378463 0.28271132226544 no 2425 0.283183046593274 3378 442583 SGTC_891 0929-0073 133 µM -0.575131665268936 0.282139819315654 no 2426 0.282601126919185 3485 5603632 SGTC_2692 st077426 47.7 µM -0.575729253300757 0.281941406453271 no 2427 0.282399099594969 3496 25238571 SGTC_2804 7954240 19.48 µM -0.578532319846528 0.281011622574622 no 2428 0.2814523917234 3493 828705 SGTC_1341 1486-1360 280 µM -0.579772102000394 0.280600856972941 no 2429 0.281034156611389 3413 3976547 SGTC_2910 7948405 25.97 µM -0.580988769896328 0.280198032262699 no 2430 0.280624011154804 3478 2971328 SGTC_1277 0873-0036 22 µM -0.580998980932331 0.280194652692337 no 2431 0.28062057018407 3499 5965735 SGTC_2545 solidagenone 89.61 µM -0.582300879072198 0.279763922291888 no 2432 0.280182016739136 3361 6708572 An anti ulcer agent SGTC_530 4358-1714 28 µM -0.584843707979478 0.278923560088945 no 2433 0.279326406057484 3486 1564641 SGTC_2895 9054447 58.44 µM -0.585057851872814 0.278852845236847 no 2434 0.27925440894989 3472 2697450 SGTC_3313 9133968 57.047 µM -0.585726946388333 0.278631952277531 no 2435 0.279029511470096 3477 1494643 SGTC_3315 9136395 68.55 µM -0.585963854364175 0.278553760583698 no 2436 0.278949902575574 3566 16876844 SGTC_804 1595-0054 20.9 µM -0.588546598654023 0.277702017558675 no 2437 0.278082732845236 3422 761523 Stimulates phospholipase C. SGTC_379 3970-0972 5.9 µM -0.590232965792331 0.277146571025893 no 2438 0.277517236912256 3471 2898042 YBL034C STU1 SGTC_231 b-estradiol 524 µM -0.59139472804602 0.276764232530512 no 2439 0.277127985964765 3425 450 A steroid. SGTC_4 0960-0234 25.671 µM -0.592094215355741 0.276534154421557 no 2440 0.276893750154136 3505 6821112 SGTC_2079 5212404 121 µM -0.592885389116781 0.276274031508358 no 2441 0.276628928397488 3529 758462 SGTC_2366 9070441 60.58 µM -0.594063786921821 0.275886819394269 no 2442 0.276234725246332 3462 6837235 SGTC_3298 9116858 71.43 µM -0.595011084231091 0.275575738487908 no 2443 0.27591803091509 3529 2506942 SGTC_72 0744-0168 198.391 µM -0.597074247183183 0.274898818398034 no 2444 0.275228905402558 3419 677577 SGTC_2428 5615643 7.78 µM -0.598309419251598 0.274493953154691 no 2445 0.274816746389795 3507 2253075 SGTC_246 cycloheximide 667 µM -0.598849988447904 0.274316857753914 no 2446 0.274636462048261 3406 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2081 5214970 32.255 µM -0.599045360098564 0.274252866099642 no 2447 0.2745713183252 3501 2063512 SGTC_820 1582-0060 59.9 µM -0.599788903153926 0.274009394872189 no 2448 0.274323464867178 3443 3848840 SGTC_749 1000-0129 128 µM -0.600225399259439 0.273866515141639 no 2449 0.274178014250587 3567 708470 SGTC_590 k048-0076 22.4 µM -0.602597194035113 0.27309079209736 no 2450 0.273388343742445 3529 6832814 SGTC_1421 4029-0249 71.4 µM -0.605096689445876 0.272274483344434 no 2451 0.272557376901333 3595 2894095 SGTC_1649 st011737 51.3 µM -0.605228622906411 0.272231428983836 no 2452 0.272513549980707 3483 1761035 SGTC_697 0508-1955 564 µM -0.605384673405229 0.27218050878408 no 2453 0.272461716148771 3534 6243113 SGTC_854 0422-0053 192 µM -0.60544376723925 0.272161227352761 no 2454 0.272442088781822 3543 3596728 SGTC_2387 9077560 195.08 µM -0.605743273802397 0.272063513297602 no 2455 0.272342621771028 3446 5303272 SGTC_1284 0929-0043 16 µM -0.606257609486607 0.27189575192287 no 2456 0.272171851479917 3461 1239883 SGTC_2544 sphondin 68.51 µM -0.606584490523964 0.271789159567135 no 2457 0.27206334775281 3551 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2635 hydroquinidine 100 µM -0.607854954068526 0.27137507278652 no 2458 0.27164183896027 3513 442912 An experimental heart treatment. SGTC_954 1189-0853 2.85 µM -0.608304794604886 0.271228530029176 no 2459 0.271492670831469 3528 2828194 SGTC_2093 5331342 194.4 µM -0.61042010746443 0.270539962341367 no 2460 0.27079177585523 3552 33839 SGTC_704 1310-0270 142 µM -0.611618311286546 0.270150315917701 no 2461 0.270395160040238 3514 5718033 SGTC_2688 kanamycin b 96.69 µM -0.612307090397497 0.269926457514008 no 2462 0.270167299698111 3646 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_875 0709-0210 25.7 µM -0.613495471878599 0.269540442991561 no 2463 0.26977438796056 3560 6251364 SGTC_3296 9122258 64.045 µM -0.614112264126943 0.269340203330189 no 2464 0.269570572268054 3528 4730474 SGTC_2098 5376439 882.5 nM -0.614735706252941 0.269137880637095 no 2465 0.269364637598673 3563 2844116 SGTC_2147 5545932 89.7195 µM -0.61540937363728 0.268919344331987 no 2466 0.26914220128401 3526 797404 SGTC_1375 2910-0797 186 µM -0.617800527203288 0.268144379106686 no 2467 0.268353417946847 3500 742508 SGTC_1469 k284-2957 126 µM -0.61822486808253 0.268006969104808 no 2468 0.268213559795034 3554 23884841 SGTC_350 k064-0020 19.8 µM -0.618727347050883 0.267844302297664 no 2469 0.268047995617797 3555 2790705 SGTC_3274 9138298 49.47 µM -0.618782736739066 0.267826374115888 no 2470 0.268029748155679 3521 17015756 SGTC_37 0566-0070 1.56 µM -0.618938251120233 0.267776041442224 no 2471 0.26797851916882 3546 1626686 SGTC_217 ketoconazole 989 nM -0.619923265103694 0.26745734958494 no 2472 0.267654153966941 3519 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1676 st018489 23.4 µM -0.620614383869441 0.267233858962479 no 2473 0.267426686680677 3503 3696235 SGTC_1103 duloxetine 36.1 µM -0.620838474782371 0.267161413773131 no 2474 0.267352952782152 3609 60835 A selective serotonin reuptake inhibitor. SGTC_1626 st003712 1.76 µM -0.62336012271073 0.266346887322125 no 2475 0.266523948399131 3537 24207035 SGTC_1210 3013-0140 750 nM -0.623396623459864 0.266335106318705 no 2476 0.266511958147527 3578 905973 SGTC_2887 9044784 58.44 µM -0.624298386407012 0.266044136532813 no 2477 0.266215821714987 3567 6465546 SGTC_3156 9099931 49.47 µM -0.624493065794902 0.265981340918603 no 2478 0.266151911417705 3528 18111053 SGTC_3337 9144342 33.5465 µM -0.625018944544618 0.265811751470199 no 2479 0.265979312225395 3535 17682949 SGTC_2239 6685329 187.64 µM -0.625701400967691 0.265591749384024 no 2480 0.265755407090283 3564 805680 SGTC_2553 4-methylesculetin 85.09 µM -0.626027329697427 0.265486712998161 no 2481 0.265648507808521 3540 5319502 SGTC_2714 st079313 56.9 µM -0.627057825284409 0.265154756003821 no 2482 0.265310665664411 3559 2939799 SGTC_987 1497-1013 404 µM -0.628963686942203 0.264541370341891 no 2483 0.264686414921438 3551 1676435 SGTC_1722 st034304 3.6505 µM -0.630391804219836 0.264082216360636 no 2484 0.264219135855596 3547 4036148 YLR033W RSC58 SGTC_2533 agelasine 13.65 µM -0.630965701682253 0.263897817023769 no 2485 0.264031475378486 3623 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2549 cedrol 20.94 µM -0.631230009848984 0.263812914089912 no 2486 0.263945071295293 3536 6708665 A sedative which affects the nervous system. SGTC_1746 st038117 42 µM -0.632603290691912 0.263372003428372 no 2487 0.263496368822077 3548 2898218 SGTC_909 3448-9333 149 µM -0.632800820384546 0.263308614774303 no 2488 0.263431860487366 3544 3344074 SGTC_3037 9091026 49.47 µM -0.633202441955183 0.263179755643827 no 2489 0.263300725633975 3583 25236398 YIL048W NEO1 SGTC_3021 9087658 49.47 µM -0.636368438658621 0.262165083868257 no 2490 0.262268153548304 3577 25237042 SGTC_34 0469-0683 81.75 µM -0.637008066217566 0.261960332997266 no 2491 0.262059794755497 3550 3690923 SGTC_960 1222-0186 7.7 µM -0.638054088693632 0.261625668009591 no 2492 0.26171923567062 3579 3126296 SGTC_831 k061-1017 217 µM -0.638408474286088 0.261512335478464 no 2493 0.26160390799338 3605 1240153 SGTC_209 4077-0173 175.592 µM -0.639685331604445 0.261104205549835 no 2494 0.261188596812617 3515 15993494 SGTC_1996 st072960 66.8 µM -0.639734614774501 0.261088459425282 no 2495 0.261172573740571 3594 1719405 SGTC_1021 4476-0760 85.3 µM -0.640641525270918 0.260798785893575 no 2496 0.260877806854157 3511 746768 SGTC_2378 9074213 121.43 µM -0.641113435775448 0.260648119820844 no 2497 0.260724492740481 3577 657714 SGTC_1799 st045822 46.1415 µM -0.641468759782393 0.26053470569588 no 2498 0.260609085811378 3573 3674992 SGTC_1652 st011932 78 µM -0.646238132289922 0.259014856291276 no 2499 0.259062573879708 3563 1551076 SGTC_1487 3970-0795 2.82 µM -0.649364324122009 0.258021130645458 no 2500 0.258051458951244 3623 3765103 SGTC_1909 st060837 51.5 µM -0.649947574155959 0.257835951507263 no 2501 0.257863043192914 3547 678937 SGTC_1369 1866-0067 208 µM -0.650418321490655 0.257686541758362 no 2502 0.257711022897508 3622 3531355 SGTC_1140 3229-1848 2.98 µM -0.650840963712444 0.257552438319071 no 2503 0.257574577023802 3594 2849525 SGTC_947 3447-0010 211 µM -0.651249490806029 0.257422848038024 no 2504 0.257442723748253 3617 748350 SGTC_779 1360-0071 233 µM -0.651930307052309 0.257206959278367 no 2505 0.257223066317904 3656 7566 SGTC_46 0329-0187a 2.197 µM -0.652485456184954 0.257030989612647 no 2506 0.257044026060167 3577 46494817 SGTC_103 0844-0104 51.839 µM -0.653139567134823 0.256823731688622 no 2507 0.256833152997426 3636 5375804 SGTC_1872 amphotericin b 148 nM -0.654614638215959 0.256356668387498 no 2508 0.256357948496138 3582 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3048 9093155 49.47 µM -0.65747130623709 0.255453399633586 no 2509 0.2554389575417 3592 25236002 SGTC_1394 3474-0001 65.7 µM -0.657773947397003 0.25535780304054 no 2510 0.255341698736729 3536 5017666 YIL048W NEO1 SGTC_2280 7785178 200 µM -0.65805593228911 0.25526874806368 no 2511 0.255251095591654 3597 2954328 SGTC_1030 k029-0042 36.7 µM -0.658513326554267 0.25512433076231 no 2512 0.255104168295744 3602 6080581 SGTC_1225 1216-0074 20.6 µM -0.660048209394391 0.254640020549633 no 2513 0.25461144626777 3595 4241466 SGTC_1688 st021091 57.6 µM -0.660222916051525 0.254584924914794 no 2514 0.254555394241051 3623 3656366 SGTC_2431 5490079 200 µM -0.660469270458068 0.254507244998874 no 2515 0.254476366087733 3623 5722345 SGTC_700 3453-2283 142 µM -0.660929366830656 0.254362201708791 no 2516 0.254328805974491 3676 565664 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.662376776595128 0.253906195054365 no 2517 0.253864891648605 3638 1273210 SGTC_2432 5630864 12.22 µM -0.663258362457573 0.253628661694301 no 2518 0.253582549314499 3592 5714970 SGTC_2921 7974240 10.71 µM -0.663319153044097 0.253609529993266 no 2519 0.253563086213263 3614 2979074 YDR527W RBA50 SGTC_261 5-fluorouridine 15.376 µM -0.664134739564539 0.253352926120199 no 2520 0.253302038752431 3643 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1205 4161-2785 76 µM -0.664338153083419 0.253288948421412 no 2521 0.253236953539244 3587 3498106 SGTC_507 nimesulide 162 µM -0.664410699448938 0.253266133165448 no 2522 0.253213743366582 3659 4495 A COX2 inhibitor. SGTC_275 trichlorophene 5.69 µM -0.666476157839166 0.252617016489286 no 2523 0.252553399076339 3652 62616 SGTC_2540 epiandrosterone 100 µM -0.667158056926274 0.252402906968773 no 2524 0.252335589623839 3694 441302 A steroid. SGTC_2967 9089538 49.85 µM -0.667368785362847 0.252336759690533 no 2525 0.252268299632852 3631 728216 SGTC_1873 rapamycin 2 nM -0.668526217398666 0.251973606855157 no 2526 0.251898876173842 3621 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1673 st016611 27.3 µM -0.668562650074577 0.251962180313439 no 2527 0.251887252408965 3636 5226799 SGTC_1759 st043059 70 µM -0.668761329432166 0.251899872437404 no 2528 0.251823869180294 3612 669426 SGTC_2218 6965428 192.983 µM -0.668992350985136 0.251827431946054 no 2529 0.251750178645585 3599 675684 SGTC_729 4092-0585 94.1 µM -0.670814311796009 0.251256512687739 no 2530 0.251169414503607 3613 2169061 SGTC_83 0170-0301 39.027 µM -0.672629938912808 0.250688259688123 no 2531 0.250591374954443 3584 3089716 SGTC_576 1073-0113 22.7 µM -0.673126333217242 0.250533017307378 no 2532 0.250433461117622 3774 5439563 SGTC_1911 st060208 74.3 µM -0.673905310531891 0.250289502625009 no 2533 0.250185757833184 3642 688783 SGTC_1067 clotrimazole 1.36 µM -0.674648477376769 0.250057299615154 no 2534 0.249949562920682 3660 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_724 3910-0327 137 µM -0.674734566667312 0.250030408343688 no 2535 0.249922209484416 3637 2885483 SGTC_658 3253-0951 102 µM -0.674742105358967 0.250028053594193 no 2536 0.24991981426653 3637 1184878 SGTC_1607 st000305 50.6 µM -0.675524450729047 0.249783747940576 no 2537 0.249671311178007 3640 5457690 SGTC_3238 9133470 49.47 µM -0.675656680316694 0.249742468681864 no 2538 0.249629322925691 3652 3534688 SGTC_2355 9061122 103.12 µM -0.67754563082292 0.249153174308522 no 2539 0.249029914332898 3622 5302957 SGTC_2341 7987486 176.74 µM -0.678095049676051 0.248981911496692 no 2540 0.248855714632926 3639 1258686 SGTC_2487 5918373 44.05 µM -0.682879222776906 0.247493258256544 no 2541 0.247341581958757 3682 2876279 SGTC_3143 9086658 49.47 µM -0.683097746903154 0.247425375596239 no 2542 0.24727253952783 3702 25236626 SGTC_1222 0366-0074 1.18 µM -0.683143008782855 0.247411316622512 no 2543 0.247258240380447 3677 286520 SGTC_647 0140-0236 81 µM -0.68318944681783 0.247396892762227 no 2544 0.247243570121227 3654 990837 SGTC_1032 k061-1018 98.7 µM -0.683270725603164 0.247371648291625 no 2545 0.247217894426067 3730 4005393 SGTC_1657 st012939 43.4 µM -0.683301029566175 0.247362236501592 no 2546 0.247208321870895 3665 24207257 SGTC_3139 9095020 49.47 µM -0.683538271762569 0.247288560551466 no 2547 0.247133387565537 3461 25236292 SGTC_2961 9083290 32.55 µM -0.684117900700356 0.247108605200112 no 2548 0.246950359561263 3615 17741490 SGTC_758 0868-0029 16 µM -0.684643807968236 0.246945389256271 no 2549 0.24678435790195 3664 762687 SGTC_2882 9058044 58.44 µM -0.686017177558484 0.246519434556739 no 2550 0.246351138181446 3612 18076804 SGTC_3210 9128157 49.47 µM -0.686036629495973 0.246513404308425 no 2551 0.246345005134449 3651 17590849 SGTC_181 1447-1644 8.07 µM -0.686795700290363 0.246278148326939 no 2552 0.24610573984724 3610 534600 SGTC_2048 5246248 200 µM -0.687301081914584 0.246121584055961 no 2553 0.245946508596824 3650 677046 SGTC_3066 9117245 49.47 µM -0.687533308151311 0.246049659631113 no 2554 0.245873359314206 3713 17176980 SGTC_1634 st006576 41 µM -0.689480311455784 0.245447083323237 no 2555 0.245260529498124 3642 3915356 SGTC_3311 9131146 2.8755 µM -0.690010557727199 0.24528311536978 no 2556 0.245093774002743 3657 4900406 YPR165W RHO1 SGTC_2929 9013348 24.6 µM -0.690608908326827 0.245098158265733 no 2557 0.244905673846982 3675 2995952 SGTC_255 tunicamycin 200.472 nM -0.691725028885774 0.244753353025894 no 2558 0.244555012927468 3646 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1621 st003705 32.4 µM -0.692572538325016 0.244491704862481 no 2559 0.244288924560882 3695 24207032 SGTC_1192 1488-0095 21.4 µM -0.692600768334241 0.244482992119879 no 2560 0.244280064010349 3657 915875 SGTC_1796 st049173 110.4 µM -0.694064658877535 0.24403141495159 no 2561 0.243820830314963 3623 94134 SGTC_2488 5268135 45.7 µM -0.69414269202358 0.244007356125728 no 2562 0.243796363806123 3684 1270356 YLR208W SEC13 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.694694629331497 0.243837221854642 no 2563 0.243623347250133 3721 5024745 SGTC_9 0092-0002 10.449 µM -0.694791649219953 0.243807322162432 no 2564 0.24359294114409 3647 759368 SGTC_2141 5621638 7.665 µM -0.696529592260547 0.243272056402171 no 2565 0.243048615823148 3676 2856238 SGTC_673 1082-0474 110 µM -0.697247097027563 0.243051258869012 no 2566 0.242824084692344 3694 3098046 SGTC_1033 k072-0102 21.3 µM -0.697480606992151 0.242979424299019 no 2567 0.242751035867893 3641 5965931 SGTC_1344 1488-0097 29.1 µM -0.699908057758951 0.242233349369439 no 2568 0.241992362473322 3659 747966 SGTC_2812 7970281 58.44 µM -0.70026994515877 0.242122230038584 no 2569 0.241879368749899 3692 2233435 SGTC_2752 diclazuril 33.15 µM -0.70082999175359 0.241950319434037 no 2570 0.241704559336129 3722 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2844 9010103 25.97 µM -0.702318188826783 0.241493827814884 no 2571 0.241240376291978 3680 2480525 SGTC_2058 5236698 133 µM -0.703286726569276 0.241196988675944 no 2572 0.240938540464518 3693 766665 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.703808874270162 0.241037042252344 no 2573 0.240775903223235 3666 803109 SGTC_218 alverine citrate 93.75 µM -0.704462329561198 0.240836954432635 no 2574 0.240572450817115 3690 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1782 st039423 80.636 µM -0.705221327305305 0.240604663028795 no 2575 0.240336255457313 3685 2068169 SGTC_2215 7188065 200 µM -0.705389058876982 0.240553345210167 no 2576 0.240284075489 3688 940217 SGTC_548 1436-0017 110 µM -0.707170981837425 0.240008530355492 no 2577 0.239730114624844 3731 9677137 SGTC_3242 9133940 49.47 µM -0.707923914049032 0.239778527117641 no 2578 0.239496254083911 3717 17248444 SGTC_424 splitomicin 100 mM -0.708144320273776 0.239711220915528 no 2579 0.239427819546502 3719 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1887 st057648 70.8 µM -0.708394511141965 0.239634831770546 no 2580 0.239350150035839 3687 688672 SGTC_1307 1187-1599 12.2 µM -0.709111351854255 0.239416037063526 no 2581 0.239127689492068 3694 1538471 SGTC_3038 9091290 49.47 µM -0.709449507944387 0.239312862669416 no 2582 0.239022787165474 3705 25236843 SGTC_1124 fisetin 1.16336 µM -0.710017630853499 0.239139578073606 no 2583 0.238846601496744 3703 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1390 3413-2614 145 µM -0.710126408660272 0.239106407305175 no 2584 0.238812875543677 3730 3421432 SGTC_2648 atorvastatin 78.68 µM -0.710211801295064 0.239080369386937 no 2585 0.238786401858134 3696 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2291 7917025 104.35 µM -0.712392007610854 0.23841610619641 no 2586 0.238111031674406 3661 2964612 SGTC_1947 st076332 61.6 µM -0.713299627458893 0.238139871658479 no 2587 0.237830183985084 3674 24208416 SGTC_2600 tangeritin 87.95 µM -0.713986264006113 0.237931010076593 no 2588 0.237617836621971 3665 68077 A bioactive flavone. SGTC_3067 9117431 49.47 µM -0.716037634724729 0.237307621370255 no 2589 0.236984055393651 3720 17150885 SGTC_14 0354-0009 295 µM -0.717252081650795 0.236938987597167 no 2590 0.236609284249363 3747 1713507 SGTC_1628 st004252 77.7 µM -0.717842177049122 0.236759983469525 no 2591 0.236427302075905 3692 692968 SGTC_3026 9090633 49.47 µM -0.717966212733021 0.236722366982322 no 2592 0.23638905995508 3712 25236842 SGTC_1678 st019265 80.2 µM -0.718072138082562 0.236690245445747 no 2593 0.23635640422649 3715 5367020 SGTC_538 2922-0838 53.3 µM -0.719103092783938 0.236377736860525 no 2594 0.236038700931912 3719 777039 SGTC_2595 hexamethylquercetagetin 100 µM -0.719583613812987 0.236232156364262 no 2595 0.235890702004789 3661 386331 SGTC_1078 idebenone 36.1 µM -0.719922241639566 0.236129594044319 no 2596 0.235786436458608 3740 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2526 patulin 37.61 µM -0.721114820034555 0.235768585782658 no 2597 0.235419436798362 3753 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1367 1812-0510 76.9 µM -0.721245290214854 0.235729109318615 no 2598 0.235379305528491 3718 1142582 YDR527W RBA50 SGTC_936 3005-4620 401 µM -0.721753890521091 0.235575256532492 no 2599 0.235222901421503 3720 777207 SGTC_602 3130-1533 38.1 µM -0.722367084324881 0.235389837646384 no 2600 0.235034409183605 3727 720941 SGTC_2204 7233102 200 µM -0.72272638772327 0.235281228136035 no 2601 0.234924000175707 3636 2172480 SGTC_1788 fluconazole 20 µM -0.72586264217953 0.234334383101908 no 2602 0.23396149011544 3718 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1012 4112-3522 18 µM -0.725984793576197 0.234297547930058 no 2603 0.233924046355359 3698 3112398 SGTC_2771 fluoxetine 41.05 µM -0.726318670637659 0.23419688251269 no 2604 0.233821718068733 3700 3386 A selective serotonin reuptake inhibitor. SGTC_756 0508-1999 28.3 µM -0.727622846804062 0.233803897145917 no 2605 0.233422245530837 3708 6753853 SGTC_912 3474-0017 2.18 µM -0.727771748949868 0.233759051951899 no 2606 0.233376660511541 3741 3360550 SGTC_974 1326-0144 138 µM -0.72848470446793 0.233544395614321 no 2607 0.233158464208332 3761 5411856 SGTC_2709 st078560 56 µM -0.729714346078804 0.23317443264322 no 2608 0.232782405071045 3715 17250903 SGTC_1792 st045773 43.6 µM -0.729938153634723 0.233107130549593 no 2609 0.232713994672022 3645 2919270 SGTC_3040 9091894 49.47 µM -0.730105451134178 0.23305682887332 no 2610 0.232662864784376 3637 25236966 SGTC_71 0417-1750 47.813 µM -0.732080948189887 0.232463308206077 no 2611 0.232059580776557 3686 6811472 SGTC_161 4065-0411 162.148 µM -0.733646643381776 0.231993506637791 no 2612 0.231582062724608 3764 1906281 YLR208W SEC13 SGTC_3118 9124250 49.47 µM -0.734250761213741 0.231812376841996 no 2613 0.231397960646534 3686 1504786 SGTC_808 0711-0032 135 µM -0.734664875576509 0.231688260412071 no 2614 0.231271808398626 3689 4252555 SGTC_1539 benzyladenosine 56 µM -0.735051089386928 0.231572539586014 no 2615 0.231154190118593 3716 92208 A nucleotide analog. SGTC_1524 corynanthine 62.1 µM -0.736937390221733 0.231007812488762 no 2616 0.230580212388253 3830 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2078 5212016 200 µM -0.737361164508283 0.230881047351607 no 2617 0.230451372828782 3655 1899708 SGTC_969 1313-0238 134 µM -0.737793517778698 0.230751755991925 no 2618 0.230319966495181 3758 5212874 SGTC_738 1315-0003 72.4 µM -0.738912757243668 0.230417245417564 no 2619 0.229979987631608 3735 6251474 SGTC_1484 3473-2379 286 µM -0.738920390822068 0.230414964877461 no 2620 0.229977669829565 3843 671917 SGTC_312 4092-0653 6.84 µM -0.740098267319735 0.230063224183188 no 2621 0.229620184997039 3733 1148278 SGTC_2485 5633444 17.78 µM -0.740213300260139 0.230028888844103 no 2622 0.229585289259086 3750 5724239 SGTC_2924 9010168 62.78 µM -0.746646707931234 0.228113199004815 no 2623 0.227638423118959 3832 2993929 SGTC_1260 0700-1617 7.75 µM -0.746692086943858 0.228099718337267 no 2624 0.227624723697627 3776 2853078 SGTC_1956 st077085 54 µM -0.749208907032241 0.227352752603638 no 2625 0.226865650743493 3799 24208685 SGTC_1075 aripiprazole 15.2 µM -0.749256527672569 0.227338632595675 no 2626 0.226851302135666 3775 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1232 0279-0259 161 µM -0.749270023364136 0.227334631074652 no 2627 0.226847235832677 3776 1560000 SGTC_2593 nobiletin 86.24 µM -0.749451943434077 0.227280694993537 no 2628 0.226792426639481 3750 72344 An anti-infammatory. SGTC_1570 verbenone 133 µM -0.750002985851611 0.227117364678092 no 2629 0.226626453226188 3756 29025 A natural terpanoid with antifungal properties. SGTC_2950 9072895 21.46 µM -0.750398357216918 0.227000216422673 no 2630 0.226507410029012 3710 17332245 SGTC_3189 9110682 49.47 µM -0.750466260310725 0.226980100213202 no 2631 0.226486968496485 3830 17122418 SGTC_3101 9120531 49.47 µM -0.755147985932682 0.225595570970519 no 2632 0.225080096843846 3787 24824904 SGTC_3172 9105863 49.47 µM -0.755243167682811 0.225567472477393 no 2633 0.225051545913843 3730 2348785 SGTC_978 1416-0512 87.4 µM -0.755510030499906 0.225488702779274 no 2634 0.224971508092079 3824 6814003 SGTC_2052 5265182 7.135 µM -0.758385275339795 0.224641007131924 no 2635 0.224110185111788 3768 1239884 SGTC_2425 5628681 7.85 µM -0.759556554139565 0.224296203072391 no 2636 0.223759848500086 3820 5714958 SGTC_926 2268-1401 59.4 µM -0.760308220539234 0.224075083962641 no 2637 0.223535184613428 3753 2931578 SGTC_2450 5739737 12.93 µM -0.760821346338349 0.223924207929936 no 2638 0.223381891309587 3792 2262825 SGTC_2045 5106652 78.05 µM -0.762881599405957 0.223319006614564 no 2639 0.222767005446675 3758 673349 SGTC_474 dl-dihydrosphingosine 5 µM -0.762924454475068 0.223306427787489 no 2640 0.222754225530505 3775 3058739 A sphingolipid protein kinase C inhibitor. SGTC_817 1391-0715 46 µM -0.763182773933946 0.223230614357802 no 2641 0.22267720029606 3772 1353946 SGTC_322 k048-0136 19.3 µM -0.763805726676369 0.223047846043285 no 2642 0.2224915118244 3819 6823282 SGTC_2541 muurolladie-3-one 83.07 µM -0.76421474103774 0.222927891540119 no 2643 0.222369641701172 3792 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2403 6032726 181.2 µM -0.766518977890551 0.22225279894064 no 2644 0.221683782076789 3836 2881040 SGTC_579 4491-1009 110 µM -0.767378568437161 0.222001256176522 no 2645 0.221428233526813 3914 1271041 SGTC_1472 k841-0093 193 µM -0.768515204392576 0.221668891063113 no 2646 0.221090580609146 3866 X1472 SGTC_495 decylubiquinone 155 µM -0.769262409972427 0.221450554746278 no 2647 0.220868773791346 3789 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3256 9138902 49.47 µM -0.769410313588529 0.22140735132798 no 2648 0.220824883942195 3810 17228773 SGTC_1691 st019933 84.6 µM -0.771310712816736 0.220852663743655 no 2649 0.220261392014174 3746 6176082 SGTC_1857 st056007 79.3 µM -0.771807583467 0.220707768701643 no 2650 0.22011419978201 3785 619834 SGTC_3051 9093778 49.47 µM -0.774096539731467 0.220040977793055 no 2651 0.219436851799788 3806 17217378 SGTC_1218 1348-1416 30.7 µM -0.774764450698374 0.219846628124252 no 2652 0.219239429508521 3748 6787668 SGTC_1175 0741-0056 27.6 µM -0.774796171246012 0.219837400486213 no 2653 0.219230056033792 3861 765927 SGTC_2981 9013952 38.96 µM -0.77645370935038 0.21935552522683 no 2654 0.218740571381302 3716 2996344 SGTC_1568 digitonin 820 nM -0.777828102123275 0.21895642596569 no 2655 0.218335179286214 3788 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2143 5623677 140.463 µM -0.77887603553097 0.218652405549935 no 2656 0.218026370954779 3751 5375313 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.779354991438039 0.218513534564312 no 2657 0.217885314596802 3741 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1014 4130-3005 69.3 µM -0.779576290801862 0.218449387025201 no 2658 0.217820157938659 3811 743608 SGTC_442 cape 100 µM -0.780245316715941 0.218255523984328 no 2659 0.217623246550055 3752 5281787 SGTC_1237 0330-0133 46.1 µM -0.780574352635955 0.218160215916571 no 2660 0.217526440583129 3747 X1237 YHR072W ERG7 SGTC_1214 0358-0031 63.7 µM -0.781881083318576 0.217781947062137 no 2661 0.217142231573616 3935 4301366 SGTC_1980 st071811 45.7 µM -0.783342913837538 0.217359229031811 no 2662 0.216712884607177 3924 4974850 SGTC_3089 9117425 49.47 µM -0.783515713353999 0.217309291868108 no 2663 0.216662164989118 3741 9401657 SGTC_1906 st060206 94.7 µM -0.784579511573665 0.217002011839922 no 2664 0.216350073266277 3788 5133468 SGTC_2309 7664088 163.95 µM -0.785411790278805 0.216761781818483 no 2665 0.216106085097232 3794 704922 SGTC_2847 9005661 71.43 µM -0.786360749148771 0.216488060807412 no 2666 0.215828085880754 3771 2991449 SGTC_1197 1601-0112 267 µM -0.786585745578961 0.216423191395576 no 2667 0.215762203178793 3803 7350313 SGTC_1212 0520-0165 585 µM -0.787682524831238 0.216107136714733 no 2668 0.215441214907062 3896 5403258 SGTC_2380 9035439 200 µM -0.791596804180935 0.214981355537388 no 2669 0.214297905477818 3935 6462575 SGTC_159 3970-0959 50 µM -0.793099053911607 0.214550201301263 no 2670 0.213860057006162 3896 6615653 SGTC_1245 0418-0076 17.2 µM -0.7931371839637 0.214539264304302 no 2671 0.21384895033391 3871 6790114 SGTC_8 0354-0001 70 µM -0.793552512273833 0.214420155000537 no 2672 0.213727993618666 3832 4993152 SGTC_2626 ethyl orsellinate 100 µM -0.796105179130343 0.213688937226752 no 2673 0.212985452062082 3838 75653 A natural product. SGTC_2372 9071633 200 µM -0.796534477845096 0.21356610638501 no 2674 0.212860722010989 3881 21321366 SGTC_2724 maprotiline 69.64 µM -0.796598411810181 0.21354781713512 no 2675 0.212842150046253 3769 4011 A tricyclic antidepressant. SGTC_609 0986-0026 86.3 µM -0.796958507181851 0.213444823612216 no 2676 0.21273756480698 3798 2848610 SGTC_2001 4023502 57.655 µM -0.799832861829575 0.212623746842046 no 2677 0.211903820336465 3857 108941 YCR052W RSC6 SGTC_393 acivicin 6.25 µM -0.8004068892183 0.212459993694703 no 2678 0.211737545399514 3703 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1081 sertraline 6 µM -0.800999782061938 0.212290936163039 no 2679 0.211565886008917 3845 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2805 7950783 58.44 µM -0.801734773218146 0.21208146988493 no 2680 0.211353198250201 3870 1178958 YDL195W SEC31 SGTC_2276 7947513 42.08 µM -0.802212388938819 0.211945418241815 no 2681 0.211215055561295 3724 2105100 SGTC_1016 4226-1401 38 µM -0.80230210329493 0.211919868277071 no 2682 0.211189113025655 3813 2901613 SGTC_3144 9087057 49.47 µM -0.803392488515155 0.211609478928674 no 2683 0.210873957614863 3706 17249618 SGTC_1286 0929-0070 131 µM -0.806596892682473 0.210698854026483 no 2684 0.209949382279588 3930 1420408 SGTC_1494 4358-1428 177 µM -0.807758725783807 0.210369253975272 no 2685 0.209614744819905 3853 1564571 SGTC_2371 9071574 200 µM -0.809405562314501 0.209902582459644 no 2686 0.209140951895299 3820 45596039 SGTC_1575 cyproterone acetate 48 µM -0.810970709559067 0.20945962404234 no 2687 0.208691245817708 3864 9880 An androgen receptor antagonist and liver toxin. SGTC_690 glyoxal 20.3 µM -0.811134754023536 0.209413229043407 no 2688 0.208644144747848 3708 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_929 2805-0021 398 µM -0.81443349082557 0.208481565458246 no 2689 0.207698329563109 3928 3098024 SGTC_3087 9117406 49.47 µM -0.816381686056456 0.207932485789984 no 2690 0.207140933893263 3826 42546093 SGTC_1923 st058458 19.1 µM -0.81889643048576 0.207224993670515 no 2691 0.2064227533263 3850 3534982 SGTC_3345 9148410 3.559 µM -0.819126809095124 0.207160250772918 no 2692 0.206357033836322 3823 4903596 SGTC_835 0312-0010 67.2 µM -0.821818002511455 0.206404836022067 no 2693 0.205590243117566 3823 1626196 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.823098660738727 0.206045930715435 no 2694 0.205225945175188 3909 23847180 SGTC_1716 st033144 30.6155 µM -0.823115600396963 0.206041185846511 no 2695 0.205221129066351 3838 674617 SGTC_3285 9112818 20.8695 µM -0.826130594407917 0.205197705973275 no 2696 0.204365007106931 3856 17017947 YPR165W RHO1 SGTC_2165 5727197 32.143 µM -0.826774781025781 0.205017753601607 no 2697 0.204182363289716 4002 1361712 SGTC_1256 0570-0116 285 µM -0.826829530068843 0.205002463881369 no 2698 0.204166844982234 3888 410638 SGTC_2517 totarol 10 µM -0.827210492850612 0.204896091487932 no 2699 0.204058882681391 3886 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1133 3473-0247 50 µM -0.829109272384358 0.204366404056269 no 2700 0.203521288679413 3888 711311 SGTC_778 3456-2434 196 µM -0.831467968313386 0.203709553919797 no 2701 0.20285465814495 3898 5539063 SGTC_1209 2323-2347 50.3 µM -0.831827266934631 0.203609606952141 no 2702 0.202753225351877 3827 5412760 SGTC_2304 7443016 91.4 µM -0.832076106464344 0.203540403800399 no 2703 0.202682993784251 3814 939854 SGTC_105 0111-0055 734.78 µM -0.833085119802693 0.203259937434432 no 2704 0.202398362542256 3894 5179370 SGTC_2100 5377183 190 µM -0.835047894944718 0.202715023639697 no 2705 0.201845371065774 3904 2844202 SGTC_1114 scopoletin 1.73284 µM -0.835592716642792 0.202563922899323 no 2706 0.201692033770679 3873 5280460 A coumarin with genotoxic properties. SGTC_3308 9128332 17.569 µM -0.836078838368981 0.202429158849316 no 2707 0.201555276200401 3911 17332805 YDL196W YDL196W SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.837903574364523 0.201923778844211 no 2708 0.201042430571758 3906 5357218 A potent inhibitor of glutathione S-transferases. SGTC_687 k029-0044 34.9 µM -0.837936095106089 0.20191477873557 no 2709 0.201033297658502 3939 5829338 SGTC_435 c-PAF 6.7 µM -0.838421392651805 0.201780501270845 no 2710 0.200897039425192 3902 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1569 carminic acid 40.6 µM -0.8407466591403 0.201137863237973 no 2711 0.200244937639867 3953 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2641 levomentholum 100 µM -0.84236000779018 0.200692701310572 no 2712 0.199793235656592 3845 16666 SGTC_477 mead ethanolamide 10 µM -0.843241901941548 0.20044961558568 no 2713 0.199546584067178 3748 16061185 SGTC_345 1362-0200 395 µM -0.84612011261209 0.199657495523077 no 2714 0.198742870897844 3896 1419823 SGTC_1752 st044819 83.042 µM -0.846445783478861 0.199567985539969 no 2715 0.1986520534602 3910 441209 YML126C ERG13 SGTC_2306 7482397 179.52 µM -0.84767937995731 0.199229153083179 no 2716 0.19830827649562 3885 891448 SGTC_2707 st078556 66.6 µM -0.849190571041809 0.198814546139862 no 2717 0.197887629537384 3872 17250899 SGTC_48 0382-0018 55 µM -0.850400235515315 0.198483040470747 no 2718 0.197551302624604 3946 762596 SGTC_1336 1486-0901 104 µM -0.850498852211487 0.19845602950904 no 2719 0.197523899149527 3919 5006114 SGTC_3106 9121286 49.47 µM -0.850904350790375 0.198344987380338 no 2720 0.197411243904467 3924 15943471 SGTC_2382 9035899 200 µM -0.852137749737979 0.19800746274621 no 2721 0.197068821043406 3905 6462679 SGTC_711 k292-0785 179 µM -0.853128823983339 0.197736502761554 no 2722 0.196793934306824 3875 4146315 SGTC_1345 1488-0192 31.4 µM -0.856137830925119 0.196915213303031 no 2723 0.195960772652193 3910 658348 SGTC_1196 1588-0294 184 µM -0.856424306350138 0.196837129455972 no 2724 0.195881562411863 3923 6144269 SGTC_1751 st044839 27.194 µM -0.856588290871996 0.196792441068418 no 2725 0.195836229559328 3858 5291326 SGTC_2088 5278280 127.392 µM -0.856854438431961 0.196719924708947 no 2726 0.195762667704884 3975 791502 SGTC_1224 0823-0416 294 µM -0.857325511656818 0.196591612601334 no 2727 0.195632506541575 3993 3598164 SGTC_3206 9114350 49.47 µM -0.85770565628849 0.196488104829477 no 2728 0.195527507967819 3833 17087243 SGTC_3188 9110789 49.47 µM -0.85801671579066 0.196403432491005 no 2729 0.195441616647689 3891 849217 SGTC_334 1502-1024 68.5 µM -0.858037389884512 0.196397805657461 no 2730 0.195435908824822 3966 3296216 SGTC_2682 pyrogallin 40.03 µM -0.859909595966386 0.195888655599633 no 2731 0.194919439221697 3925 822798 An ATP competetive kinase inhibitor. SGTC_1051 3253-3903 78 µM -0.859995415840651 0.1958653359334 no 2732 0.194895784732263 3912 5509239 SGTC_1625 st003711 30.1 µM -0.861077510823318 0.195571444937891 no 2733 0.194597677222734 3970 24207034 YER133W GLC7 SGTC_2716 st080858 38.6235 µM -0.863225814815946 0.194988771541013 no 2734 0.194006661487527 3905 5296050 SGTC_1380 2291-0730 164 µM -0.86349930640164 0.194914669641537 no 2735 0.193931500308105 3964 2999191 SGTC_1233 0325-0408 14.2 µM -0.865319328544911 0.194421975238926 no 2736 0.193431772460989 3975 12874 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.865387520363009 0.194403529921103 no 2737 0.193413064151543 3920 75037 A free radical scavenger. SGTC_2971 9092186 9.93 µM -0.866014163377844 0.194234078095042 no 2738 0.193241197393675 3956 25236400 SGTC_1560 lithocholic acid 53.1 µM -0.867518381190207 0.193827686738761 no 2739 0.192829022452374 3792 9903 A bile acid which acts as a detergent. SGTC_611 3453-1652 23.7 µM -0.868835785916418 0.193472192357762 no 2740 0.192468478204849 3899 1560575 SGTC_2985 9022375 71.43 µM -0.874232671648794 0.192020029324472 no 2741 0.190995778441555 4003 4939335 SGTC_249 wiskostatin 11.211 µM -0.875410205287249 0.191704074041889 no 2742 0.190675374482472 3901 2775510 A n-wasp and actin depolymerizer. SGTC_2720 fluspirilene 36.88 µM -0.875620266648548 0.191647743956097 no 2743 0.190618252005191 3935 3396 An atypical antipsychotic. SGTC_827 3253-0474 693 µM -0.876017290220156 0.191541305747039 no 2744 0.190510317150029 3940 5402065 SGTC_2491 paeonol 100 µM -0.876171180566254 0.191500058963025 no 2745 0.190468490603499 3799 11092 Increases levels of cortical cytochrome oxidase. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.877898689866266 0.191037413144536 no 2746 0.189999350131041 3736 88881 An O-methylated flavonoid and antioxidant. SGTC_1973 st070275 50.2 µM -0.878766653382866 0.190805222002538 no 2747 0.189763905211027 3840 17118334 SGTC_1730 st033808 45.1 µM -0.879637100245322 0.19057254052317 no 2748 0.189527966940718 3903 1045166 SGTC_2968 9090663 33.37 µM -0.880476674769838 0.190348276725677 no 2749 0.189300567836374 3917 25236811 SGTC_74 000s-0487 160.283 µM -0.881123041960644 0.190175732183186 no 2750 0.189125613497919 3865 677548 SGTC_3243 9134147 49.47 µM -0.881874464154095 0.189975264567947 no 2751 0.188922348791002 3995 24282180 SGTC_2833 9001315 45.46 µM -0.882286540371375 0.189865384289166 no 2752 0.188810936596809 3933 2989378 SGTC_33 0986-0033 35.816 µM -0.884760497387484 0.189206524568116 no 2753 0.188142909534474 3857 2848082 SGTC_279 1273-0055 2.93 µM -0.885611838735035 0.188980122857486 no 2754 0.18791336493455 3953 2847562 SGTC_603 3794-0023 45.9 µM -0.886409757718206 0.188768079615982 no 2755 0.18769838150329 3956 3802260 SGTC_1392 3455-1037 33.9 µM -0.887218358855114 0.188553347297938 no 2756 0.187480675044258 3964 981132 SGTC_415 dibenzyl ketone 100 µM -0.888305247251783 0.188264950343395 no 2757 0.187188288953424 3968 7593 SGTC_1901 st060216 58.6 µM -0.888476659590511 0.188219492338144 no 2758 0.187142202723052 3928 688792 SGTC_443 clozapine 122 µM -0.889463577407507 0.18795789665766 no 2759 0.186876994757733 3835 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1142 3253-1408 9.78 µM -0.89012757141261 0.187782022602389 no 2760 0.186698694940141 3906 256655 SGTC_1326 1431-2094 10.8 µM -0.894478496033361 0.186632097058935 no 2761 0.185532965135007 3951 616278 SGTC_2327 6189656 200 µM -0.894880104863589 0.186526174287962 no 2762 0.185425591518463 4058 5349088 SGTC_2732 terfenadine 20 µM -0.894967644385688 0.186503091021486 no 2763 0.185402192186612 3965 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1994 st072947 40.9 µM -0.894998544871107 0.186494943305602 no 2764 0.185393932918395 4023 5286565 YDL195W SEC31 SGTC_851 0394-0702 453 µM -0.895233797598612 0.186432920039509 no 2765 0.185331060638913 3941 762646 SGTC_164 4100-3994 89.624 µM -0.898212566908816 0.185648687127653 no 2766 0.184536117433299 3909 4615967 SGTC_2568 diosmetin 100 µM -0.898933892893804 0.185459088930793 no 2767 0.184343936805043 4020 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3163 9099914 49.47 µM -0.90002735128994 0.185171906222172 no 2768 0.184052847661516 3961 16268368 SGTC_2363 9053361 176 µM -0.90053896438976 0.185037632555643 no 2769 0.183916749655653 4042 6469797 YMR079W SEC14 SGTC_2415 st077333 57.7 µM -0.900672236588192 0.18500266499002 no 2770 0.183881307218764 3961 2766255 SGTC_3246 9135460 32.98 µM -0.900900051480386 0.184942901100003 no 2771 0.183820731928978 3881 41446951 SGTC_2816 7982706 58.44 µM -0.901143609586692 0.184879020479694 no 2772 0.183755984315629 4035 2981853 SGTC_1389 3405-0187 19 µM -0.901474904950535 0.184792150074534 no 2773 0.183667935393552 3945 799890 SGTC_2514 salinomycin 42.74 µM -0.901493264819085 0.184787336595292 no 2774 0.183663056629525 4047 23682228 A polyether potassium ionophore. SGTC_3110 9122132 49.47 µM -0.902860035710994 0.184429223753705 no 2775 0.18330009166191 4079 918317 SGTC_2899 9053889 58.44 µM -0.903590445003137 0.184238023564229 no 2776 0.183106304859817 3933 6470052 SGTC_2005 4024620 188 µM -0.907058064561325 0.183331984241966 no 2777 0.182188046301857 3969 236743 SGTC_664 1222-0054 14.9 µM -0.9078414215279 0.183127689632273 no 2778 0.181981005179489 3944 6813991 SGTC_543 3844-1095 191 µM -0.909367128411325 0.182730202623916 no 2779 0.181578183614392 3986 4230703 SGTC_2871 9038510 12.99 µM -0.910238620636667 0.182503397738632 no 2780 0.181348340314937 3914 4945164 SGTC_722 3534-0461 190 µM -0.910316730737977 0.182483078261136 no 2781 0.181327748819865 4034 658262 SGTC_1348 1493-0373 93.8 µM -0.914221543534324 0.181469086119096 no 2782 0.180300223084567 3976 3010129 SGTC_1269 0831-0796 3.05 µM -0.915253619632778 0.181201669579737 no 2783 0.180029250752465 4028 927758 SGTC_2522 biochanin a 4.94 µM -0.915559013100582 0.181122587815414 no 2784 0.179949118525467 4000 5280373 A possible chelator. SGTC_775 4577-0580 57.3 µM -0.915688904919961 0.181088958829802 no 2785 0.179915042986487 4063 2006902 SGTC_1557 sumaresinolic acid 42.3 µM -0.916076687439905 0.180988585227604 no 2786 0.179813337069264 3949 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.916354314327791 0.180916745720064 no 2787 0.179740544482011 4022 551469 SGTC_3209 9113616 49.47 µM -0.918016302049427 0.180487058938492 no 2788 0.179305165623378 4039 16649353 SGTC_1587 estradiol valerate 56.1 µM -0.918801222383345 0.180284350042738 no 2789 0.179099776495897 4051 13791 A steroid. SGTC_1646 st011709 75.6 µM -0.919223739449551 0.180175292453095 no 2790 0.178989278284435 3911 5757843 SGTC_2952 9073731 13.78 µM -0.919233067725241 0.18017288516141 no 2791 0.178986839203696 4077 16457353 SGTC_456 gingerol 170 µM -0.920146875015163 0.179937162304682 no 2792 0.178748005777743 3998 442793 A herb. SGTC_1288 0973-0013 65.5 µM -0.920988946078606 0.179720115848315 no 2793 0.178528099107012 4038 4315430 SGTC_2185 6113692 200 µM -0.922770281703591 0.179261513312394 no 2794 0.17806346550203 4006 874150 SGTC_1753 st043925 64 µM -0.929412928907876 0.17755786947851 no 2795 0.176337565018451 4063 670181 SGTC_725 1497-0963 19 µM -0.929573222767756 0.177516885482467 no 2796 0.17629604849379 4093 3549977 SGTC_214 4373-3496 70 µM -0.931578828976628 0.177004596137062 no 2797 0.17577711422938 4078 3779166 SGTC_1603 st002045 67.8 µM -0.932308904294377 0.17681834610468 no 2798 0.175588453657891 3999 5887985 SGTC_606 k015-0008 38.6 µM -0.933025666469999 0.176635612953722 no 2799 0.175403358247629 4091 1970475 SGTC_1297 1068-0111 14.1 µM -0.937107663011617 0.17559721627998 no 2800 0.174351590031713 3967 767057 SGTC_108 0509-0257 621.132 µM -0.937709830216058 0.175444362347195 no 2801 0.174196775312679 3982 536624 SGTC_1648 st011736 69.8 µM -0.93798456068624 0.175374652878626 no 2802 0.174126172266257 4010 2855514 SGTC_2962 9082311 13.18 µM -0.938354902560954 0.175280710989814 no 2803 0.174031026812944 4012 16459453 SGTC_2960 9079389 5.97 µM -0.938866464278191 0.175150999397823 no 2804 0.173899654589367 4041 16457355 SGTC_922 1866-0035 480 µM -0.940066628653501 0.174846924760126 no 2805 0.173591692536746 3956 3156169 SGTC_549 1661-1316 519 µM -0.940834483174781 0.174652556363999 no 2806 0.173394843302039 4038 2857282 SGTC_1897 st060201 15 µM -0.942445085048608 0.174245307685923 no 2807 0.172982406933482 4061 611878 SGTC_2244 6635614 200 µM -0.945777973826203 0.173404488380084 no 2808 0.172130921124389 3944 836499 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.946039154394395 0.17333870720133 no 2809 0.172064307977357 4023 676296 Flavone; oxidizing agent. SGTC_2763 lisinopril 49.32 µM -0.946084927418961 0.173327180401484 no 2810 0.17205263542996 3912 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_961 1252-1571 372 µM -0.947192999844902 0.173048288782511 no 2811 0.1717702208793 4037 6813498 SGTC_3350 9150499 3.57 µM -0.951046787639756 0.172080553468783 no 2812 0.17079031266782 4003 4910996 YPR165W RHO1 SGTC_2686 alizarin 95.37 µM -0.951672204949881 0.171923829605494 no 2813 0.170631624964174 4039 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1924 st058459 75.1 µM -0.954561649747141 0.171200944804839 no 2814 0.169899709407686 4013 688683 SGTC_1490 4089-0339 670 nM -0.95491173012028 0.17111349346745 no 2815 0.169811168634627 3969 742542 SGTC_901 1112-0062 60.1 µM -0.956791312535841 0.170644455599903 no 2816 0.169336299005939 4034 1908457 SGTC_1797 st048695 56.8 µM -0.957720552229798 0.170412874054422 no 2817 0.169101845166411 4020 592262 YIL048W NEO1 SGTC_290 2043-6722 48.1 µM -0.958352852174511 0.170255409827857 no 2818 0.168942430594143 4050 773758 YLR208W SEC13 SGTC_2566 crystal violet carbinol 226 nM -0.960641550227215 0.169686225706416 no 2819 0.168366214698756 4112 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2159 5658611 73.75 µM -0.962780576208283 0.169155368757157 no 2820 0.167828825163386 4028 793844 SGTC_1758 st042942 75.2445 µM -0.966630458923247 0.168202606599347 no 2821 0.166864401175542 3976 669317 SGTC_894 0960-0238 55.9 µM -0.969909902401873 0.167393744174929 no 2822 0.166045701857619 4060 6741907 YDL195W SEC31 SGTC_2164 5685496 200 µM -0.970506560589003 0.167246850615424 no 2823 0.165897028174479 3960 759046 SGTC_1529 apigenin 74 µM -0.971744656558034 0.16694230421393 no 2824 0.165588797341807 4092 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_70 0141-0289 43.283 µM -0.973430654769674 0.166528158534972 no 2825 0.165169654755172 4054 352408 SGTC_2158 5657123 3.6195 µM -0.974488536324915 0.166268641248443 no 2826 0.16490701417765 3985 2858827 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.975530445410552 0.166013297751163 no 2827 0.164648603606896 4023 688761 SGTC_1831 st055328 12 µM -0.975667127968958 0.165979819395122 no 2828 0.164614723564683 4068 1103068 SGTC_3356 9151811 4.48 µM -0.976201589870127 0.165848952803123 no 2829 0.164482287767516 4054 1859254 YPR165W RHO1 SGTC_1121 fusaric acid 630.51 nM -0.979999218446249 0.164920999187817 no 2830 0.163543252222649 4029 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2563 tomatine 8.54 µM -0.980916236494741 0.164697430039015 no 2831 0.163317024991451 3955 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_925 2064-1272 59.6 µM -0.981091785416843 0.164654653586411 no 2832 0.163273740483174 4043 6815817 SGTC_2528 xanthyletin 44.79 µM -0.982356420314544 0.164346709528125 no 2833 0.162962143977936 4110 65188 An natural product with antifungal activity of unknown mechanism. SGTC_849 0386-0493 241 µM -0.982765056238572 0.164247284787843 no 2834 0.162861541864811 4034 726119 SGTC_1460 k062-0059 9.15 µM -0.984030127791369 0.163939729017902 no 2835 0.162550349886403 3957 1373085 SGTC_1715 st032160 10.2275 µM -0.984240767289433 0.163888556059157 no 2836 0.16249857276865 4019 5289825 SGTC_3217 9129673 49.47 µM -0.986746133880953 0.163280694896609 no 2837 0.161883553784774 4126 17248312 SGTC_2909 7941780 10.49 µM -0.986759871492338 0.163277365870471 no 2838 0.161880185653237 4039 1243215 SGTC_2210 7115885 190.385 µM -0.986819732438851 0.16326286032226 no 2839 0.161865509723417 4134 2927039 SGTC_2620 irigenin 100 µM -0.987731865209739 0.163041935230586 no 2840 0.161641992097068 4132 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1958 st076513 41.9 µM -0.9881933155339 0.162930242713734 no 2841 0.161528990626241 4043 732122 YGL099W LSG1 SGTC_2119 5528445 120.635 µM -0.989025207356584 0.162729011776878 no 2842 0.161325404377509 4101 791935 SGTC_1514 1189-1591 158 µM -0.990398155975575 0.162397255312202 no 2843 0.16098977320996 4105 767698 YMR146C TIF34 SGTC_2874 9043904 71.43 µM -0.991851706434135 0.162046502460629 no 2844 0.160634935125535 4030 4463428 SGTC_1330 1469-0054 61.8 µM -0.993592857017207 0.161626999501061 no 2845 0.160210561555401 4083 7102664 SGTC_1509 1326-1131 80 µM -0.994023478769055 0.161523357223399 no 2846 0.160105718530742 4022 768313 SGTC_438 sphingosine 6.67 µM -0.999133654028983 0.16029674644056 no 2847 0.158864975099947 4033 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_732 3970-1727 52.7 µM -0.999938519445484 0.160104108562518 no 2848 0.158670130883085 4153 1275699 SGTC_1323 1348-1351 11.2 µM -1.00430273889145 0.159062205335628 no 2849 0.157616356947572 4033 6989654 SGTC_2697 mebhydrolin 72.4 µM -1.00444815823083 0.159027564919649 no 2850 0.157581323683565 4181 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2073 5212005 126 µM -1.00450686734611 0.159013581191646 no 2851 0.157567181403021 3874 691789 SGTC_966 1300-0360 30.2 µM -1.00487274488672 0.158926452199336 no 2852 0.15747906494268 4078 70588 SGTC_404 fumagillin 50 µM -1.00565091327185 0.158741245539906 no 2853 0.157291761736228 4097 12015870 A methionine aminopeptidase binder. SGTC_1365 1672-3266 55.4 µM -1.00790981768175 0.158204420626014 no 2854 0.156748879012677 4142 6415873 SGTC_944 3370-0224 231 µM -1.00827723037865 0.158117218383793 no 2855 0.156660695420034 4135 4580514 SGTC_596 1155-0152 116 µM -1.01137007042717 0.157384410226602 no 2856 0.155919670222467 4092 280313 SGTC_203 k066-0004 30.888 µM -1.01299789455431 0.156999616623316 no 2857 0.155530583298722 4186 6795412 SGTC_3303 9125618 40.5795 µM -1.01320106925913 0.156951632599467 no 2858 0.155482064932537 4119 22695467 SGTC_1811 st050069 61.5 µM -1.01332687072535 0.156921926746871 no 2859 0.155452028395864 4040 3877702 SGTC_2131 toluylene red 5.2905 µM -1.01353933735502 0.156871764806136 no 2860 0.155401308255485 4097 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1731 st035964 63 µM -1.01435545091318 0.156679183996102 no 2861 0.155206586758278 4045 6739575 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.01588560337868 0.156318528822255 no 2862 0.154841932638403 4186 4213774 SGTC_2712 st079126 47.7 µM -1.01949751898934 0.15546937497821 no 2863 0.153983415210962 4103 3152970 SGTC_1712 st032288 53.4 µM -1.01997387673063 0.155357611847996 no 2864 0.153870425117123 4007 2883011 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.02138110456416 0.155027757566378 no 2865 0.153536957029038 4116 688751 SGTC_2352 9027995 87.8 µM -1.02143663962584 0.155014749637369 no 2866 0.153523806815618 4066 2997347 SGTC_979 1426-2828 121 µM -1.02546392294888 0.154073363846873 no 2867 0.152572169897072 4218 747872 SGTC_1905 st060207 84.5 µM -1.02561874095618 0.154037250468381 no 2868 0.152535665079662 4082 1948547 SGTC_2068 5226020 147 µM -1.02602623795522 0.153942223094731 no 2869 0.152439608331303 4144 1810509 SGTC_2447 5741742 33.78 µM -1.02614212632142 0.153915205277679 no 2870 0.152412298016573 4175 1776504 SGTC_1093 fluphenazine 7.97 µM -1.02692216445392 0.153733431505756 no 2871 0.152228558303782 4125 6602611 An atypical antipsychotic. SGTC_753 1322-0200 289 µM -1.02782909917575 0.153522265524852 no 2872 0.152015112788945 4194 5403907 SGTC_1166 k206-0078 225 µM -1.0292462873628 0.153192679555935 no 2873 0.151681978187803 4113 5404595 SGTC_932 2857-0803 154 µM -1.03305984099763 0.152308117073171 no 2874 0.150787947652668 4186 674898 SGTC_1475 4092-1048 11.7 µM -1.03363819409485 0.152174263436802 no 2875 0.150652668431322 4133 2881759 SGTC_2110 5483698 200 µM -1.03498549250283 0.151862748641174 no 2876 0.150337843199701 4094 2848765 YHR062C RPP1 SGTC_300 r073-0011 5.04 µM -1.03670302395519 0.151466245373912 no 2877 0.149937141143594 4122 2735780 SGTC_3103 9120822 49.47 µM -1.0379831455426 0.15117116911149 no 2878 0.14963895096182 4156 17141819 SGTC_1395 3486-0190 4.35 µM -1.03832232433594 0.151093050348958 no 2879 0.14956000936495 4117 6748079 SGTC_794 k038-0031 316 µM -1.03950955401928 0.150819822339534 no 2880 0.149283908519227 4113 6624242 SGTC_153 4077-0274 519.67 µM -1.04175651677579 0.150303609181664 no 2881 0.148762289421155 4119 3121976 SGTC_1430 4049-0248 69.1 µM -1.04246003500051 0.150142226495785 no 2882 0.148599222541507 4145 22774488 SGTC_2837 9008476 45.46 µM -1.04252830125242 0.15012657279427 no 2883 0.148583405626294 4158 2992805 SGTC_1320 1313-0481 95.3 µM -1.04723362682689 0.149050246013372 no 2884 0.147495919849435 4131 6813365 YLR208W SEC13 SGTC_2055 5235184 200 µM -1.0475531639701 0.148977340388417 no 2885 0.147422262897786 4199 2836034 SGTC_2877 9040724 71.43 µM -1.05094381202335 0.148205197586005 no 2886 0.146642198350951 4141 6463895 SGTC_1138 3761-0006 1.03 µM -1.05280292304382 0.147782966003052 no 2887 0.146215662510225 4177 12061087 SGTC_995 3931-2021 34.6 µM -1.0558394784741 0.147095053221558 no 2888 0.145520779165391 4145 730143 SGTC_188 3229-0966 278.469 µM -1.05658716699162 0.146925998971875 no 2889 0.145350019918977 4191 5722370 SGTC_353 1988-1175 58.3 µM -1.05776699411102 0.146659502247239 no 2890 0.145080841889169 3994 2788357 SGTC_2231 micatex 6.853 µM -1.06427954411431 0.145194301247599 no 2891 0.143601040939365 4168 20737 An antifungal of unknown mechanism. SGTC_2787 5284540 71.43 µM -1.06652928775859 0.144690448276663 no 2892 0.143092223257576 4205 736958 SGTC_227 fluconazole 33.516 µM -1.07004975997853 0.143904368618851 no 2893 0.142298455676525 4159 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1126 isoteolin 1.0172 µM -1.0715729953817 0.143565142770207 no 2894 0.141955934020806 4105 133323 SGTC_1855 st056195 39.6 µM -1.07236792647518 0.143388325437363 no 2895 0.141777404035467 4121 4028379 SGTC_632 0781-2353 4.65 µM -1.07386720035539 0.143055240756477 no 2896 0.141441102892107 4239 6811515 YHR007C ERG11 SGTC_2035 5154463 94.595 µM -1.07539393264339 0.142716593424007 no 2897 0.141099198540074 4185 2769623 SGTC_11 0438-0307 1.3 µM -1.07830845988326 0.142071622637361 no 2898 0.140448061467102 4157 4011476 SGTC_803 4488-1585 147 µM -1.08076480442169 0.141529579842749 no 2899 0.13990087403297 4148 747204 SGTC_2448 5185112 27.17 µM -1.08275338298825 0.141091786884396 no 2900 0.13945895110279 4209 5718189 SGTC_3278 9139605 49.47 µM -1.08302706447037 0.141031606858207 no 2901 0.139398205128986 4189 7958859 SGTC_2532 xanthone 78.9 µM -1.08519955064761 0.140554514844499 no 2902 0.138916641599185 4188 7020 An insecticide. SGTC_2722 naftopidil 47.16 µM -1.08582939930853 0.140416401100496 no 2903 0.138777238434283 4104 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.0887747988326 0.139771754696314 no 2904 0.138126603730345 4210 688664 SGTC_2974 9094440 9.66 µM -1.08928775058496 0.139659693273882 no 2905 0.138013506408766 4200 25236134 SGTC_1268 0828-0275 2.46 µM -1.09055636202603 0.139382809943538 no 2906 0.137734070024052 4229 745337 SGTC_2332 7982454 138.89 µM -1.09187021242812 0.139096446797496 no 2907 0.13744507611709 4119 2981748 SGTC_1808 st050063 61.5 µM -1.09296285795964 0.138858602048864 no 2908 0.137205053859029 4177 4011993 SGTC_814 3342-0569 96 µM -1.09510720659613 0.138392630297974 no 2909 0.136734835915025 4261 4346283 SGTC_128 0906-2981 13.371 µM -1.09544477428312 0.138319373289281 no 2910 0.136660913746398 4175 6740226 SGTC_2754 granisetron 64.02 µM -1.09558714960757 0.138288483737501 no 2911 0.136629743919005 4200 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1526 st051518 75 µM -1.09691966598486 0.137999610805428 no 2912 0.136338255533448 4184 673993 SGTC_1289 0976-0073 69.1 µM -1.10071216645853 0.13717969783798 no 2913 0.135510974699999 4252 3391136 SGTC_1319 1306-0155 43.7 µM -1.10700979405113 0.135825556874573 no 2914 0.13414484693923 4251 3122360 SGTC_2206 7254556 146.969 µM -1.10796548248771 0.135620863690083 no 2915 0.133938361685832 4204 4398905 SGTC_1791 st048313 56.1 µM -1.10815950919652 0.135579332092359 no 2916 0.133896467123396 4212 1204976 SGTC_1318 1280-3875 124 µM -1.10950378729683 0.135291827439864 no 2917 0.13360645576429 4198 373245 SGTC_2817 7995342 71.43 µM -1.11302525922006 0.134540662448198 no 2918 0.132848790632763 4206 18879975 SGTC_2889 9059656 51.95 µM -1.11636254055021 0.13383143397673 no 2919 0.132133490575165 4281 3949838 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.11988779142622 0.133085054333122 no 2920 0.131380790730134 4196 140250 A respiratory chain inhibitor. SGTC_2281 7943571 200 µM -1.12117356475382 0.132813539881701 no 2921 0.131106994919528 4332 1244024 SGTC_3248 9135562 49.47 µM -1.12171049142929 0.132700271020531 no 2922 0.130992777148408 4202 17650701 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.12440918275735 0.132131968839041 no 2923 0.130419739116164 4229 5379071 SGTC_1555 citronellol 128 µM -1.12488257872763 0.132032452313322 no 2924 0.13031939760539 4174 8842 A terpine precursor. SGTC_781 4335-2806 94.4 µM -1.12704299740768 0.13157894891186 no 2925 0.129862151059079 4277 845254 SGTC_1826 st055655 41.6 µM -1.1272031428908 0.13154537489159 no 2926 0.12982830099369 4241 676168 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.12868692117833 0.131234586415677 no 2927 0.129514964239315 4199 364106 SGTC_1619 st003326 88.7 µM -1.12907015856154 0.131154396946642 no 2928 0.1294341193246 4217 2849032 SGTC_806 3966-4455 5.86 µM -1.12956467519284 0.131050973174893 no 2929 0.12932985144649 4199 714982 SGTC_1922 5578187 25 µM -1.13003963234287 0.130951693154092 no 2930 0.129229762464967 4244 1350412 SGTC_3141 9094609 49.47 µM -1.13032767292762 0.13089150951803 no 2931 0.129169089069116 4180 25236309 YDL196W YDL196W SGTC_1414 3917-0015 5.4 µM -1.13156605938226 0.130632976943301 no 2932 0.128908458061633 4214 6618702 SGTC_2492 derrusnin 100 µM -1.1316975614977 0.130605544566627 no 2933 0.128880803543247 4223 1715307 Part of coumarin class of compounds. SGTC_394 menadione 8.33 µM -1.13172694169616 0.130599416170304 no 2934 0.128874625534055 4209 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_225 nsc-122657 1.016 µM -1.13431844777285 0.130059637726254 no 2935 0.128330496825605 4233 275685 SGTC_333 3486-0131 40.1 µM -1.13621007984503 0.129666610509731 no 2936 0.127934326473359 4260 6744690 SGTC_212 3807-4682 38.772 µM -1.13685420373412 0.129532967867859 no 2937 0.127799619763013 4302 3125501 YBL034C STU1 SGTC_378 3970-0959 8.33 µM -1.13686508133011 0.129530711806978 no 2938 0.127797345759811 4261 6615653 SGTC_1221 2958-7315 257 µM -1.13889454393479 0.129110268664941 no 2939 0.127373570785401 4274 4562705 SGTC_620 0109-0052 432 µM -1.13926490669212 0.129033642934291 no 2940 0.127296340389509 4244 493037 SGTC_2456 5770359 74.46 µM -1.13978489229975 0.128926114400905 no 2941 0.12718796466661 4248 3118787 SGTC_1072 oxiconazole 14.9 nM -1.1409298178574 0.128689572796727 no 2942 0.126949564905464 4216 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3109 9122853 49.47 µM -1.1436592261069 0.128126892190015 no 2943 0.126382494606446 4258 1234709 SGTC_874 0599-0792 117 µM -1.14448629344192 0.127956726151815 no 2944 0.126211009512287 4255 765305 SGTC_1461 k072-0203 53.8 µM -1.14576781912794 0.127693367250312 no 2945 0.125945616951875 4142 5418714 SGTC_872 0588-0139 234 µM -1.14588659450886 0.127668977504318 no 2946 0.125921039347741 4198 2047100 SGTC_2177 5811945 192 µM -1.14607707698842 0.127629869937034 no 2947 0.125881630730549 4281 5343475 SGTC_2117 5521686 200 µM -1.14758583814951 0.127320403496664 no 2948 0.125569789409949 4198 803312 SGTC_1783 st039459 87.517 µM -1.15183634589788 0.126451377252644 no 2949 0.124694164655646 4350 729761 SGTC_826 1683-5028 118 µM -1.15514132459867 0.12577852858574 no 2950 0.124016278963258 4282 722377 SGTC_994 3910-0338 138 µM -1.15683666544625 0.12543435107193 no 2951 0.123669549331036 4308 3479481 SGTC_2271 7849410 118.62 µM -1.15725517625742 0.125349488881692 no 2952 0.123584060429534 4189 972430 SGTC_1396 3511-0007 98.6 µM -1.15857580925651 0.125081964564466 no 2953 0.123314567058499 4257 X1396 SGTC_896 0964-0007 44.5 µM -1.15899011620044 0.124998119482598 no 2954 0.123230106927419 4214 6756758 SGTC_1743 st037606 46.3785 µM -1.16020817942952 0.12475184218903 no 2955 0.122982028792814 4220 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_206 4546-0025 72.014 µM -1.16066664544945 0.124659233933966 no 2956 0.122888745581065 4299 6620745 YIL048W NEO1 SGTC_1060 3448-7350 82 µM -1.16291267116204 0.124206240311389 no 2957 0.122432467925205 4190 570178 SGTC_2825 7998094 58.44 µM -1.16367680809422 0.124052386864741 no 2958 0.122277505734926 4246 2987815 SGTC_863 0466-0191 129 µM -1.16427783330941 0.123931468511177 no 2959 0.122155718352224 4296 765160 YPR165W RHO1 SGTC_586 0957-0265 8.15 µM -1.16561623626759 0.123662495915844 no 2960 0.121884820165259 4116 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2473 5854593 8.94 µM -1.16864873598318 0.123054581629621 no 2961 0.121272591999731 4145 2872951 SGTC_661 1304-0007 33.6 µM -1.17166175697871 0.122452649953793 no 2962 0.120666441403722 4257 3117130 SGTC_671 0560-0003 407 µM -1.17398458310219 0.121990015822196 no 2963 0.120200600420996 4175 3238678 SGTC_1433 4060-0023 7.6 µM -1.1742181060352 0.121943573377151 no 2964 0.120153837772723 4286 3840627 SGTC_953 1188-0045 9.7 µM -1.17659252194487 0.121472060625604 no 2965 0.119679091981784 4267 6144426 SGTC_1888 azatryptophan 97.5 µM -1.17814753594151 0.121163960528372 no 2966 0.119368896948647 4313 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_386 1509-0011 3.07 µM -1.18077763792191 0.1206441015313 no 2967 0.118845534897598 4261 3107280 SGTC_1170 0310-0127 64.8 µM -1.18401583468241 0.120006207644809 no 2968 0.118203397357181 4270 774975 SGTC_210 3551-0445 56.827 µM -1.18406409233275 0.119996719359952 no 2969 0.118193846408186 4312 2865180 YOR207C RET1 SGTC_2024 5144227 134 µM -1.18662534135616 0.119493892306972 no 2970 0.117687717777974 4279 3475211 SGTC_1702 st027038 51 µM -1.18931785412115 0.118966900082439 no 2971 0.117157306085917 4302 5521182 SGTC_2671 danthron 100 µM -1.1903326501576 0.118768705546487 no 2972 0.116957836386675 4271 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_82 0054-0107 293.755 µM -1.19135378035457 0.118569509467016 no 2973 0.116757364698152 4234 3104697 SGTC_2683 piperine 63.03 µM -1.19348064654113 0.118155371157284 no 2974 0.116340593643154 4259 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2653 dihydrofissinolide 100 µM -1.19430719982295 0.11799470301368 no 2975 0.116178911147136 4322 6857746 SGTC_1252 0493-0875 34.8 µM -1.19549800424143 0.117763502349628 no 2976 0.115946257764552 4261 3960963 SGTC_3070 9117005 49.47 µM -1.19613775199309 0.117639424574684 no 2977 0.11582140374192 4363 8779016 SGTC_1139 k015-0024 46.9 µM -1.19976414351049 0.116937842193502 no 2978 0.115115476744478 4301 2766652 SGTC_1618 st003135 44.5 µM -1.20101737675216 0.116696075411812 no 2979 0.114872230424764 4258 1270615 SGTC_702 1488-0190 94 µM -1.20156955221583 0.116589665348005 no 2980 0.1147651720394 4308 949357 SGTC_1590 st077108 57.8 µM -1.20383398055564 0.116154005764675 no 2981 0.114326876508815 4299 5489485 SGTC_584 0986-0246 15.4 µM -1.20385981064807 0.116149042916017 no 2982 0.114321883803161 4385 53315 YDR232W HEM1 SGTC_2343 7990716 14.84 µM -1.20524494108393 0.115883132127911 no 2983 0.114054378903824 4285 6456862 SGTC_1656 st012921 11 µM -1.20612260428253 0.11571486638515 no 2984 0.11388511014835 4190 6732821 SGTC_2162 5663267 200 µM -1.20620263878364 0.115699530795052 no 2985 0.113869683365612 4295 6456493 SGTC_2521 angolensin 13.4 µM -1.20646210215586 0.115649824363135 no 2986 0.113819681609894 4339 821428 A flavenoid. SGTC_132 0417-1715 25.805 µM -1.20741062091304 0.115468241941601 no 2987 0.113637023645251 4282 6769098 SGTC_570 0987-0065 62.6 µM -1.21158020046435 0.114672429320502 no 2988 0.112836558723906 4118 3104428 SGTC_2814 7977482 42.97 µM -1.21252541720103 0.11449256770656 no 2989 0.112655659567198 4309 6456762 SGTC_1040 k898-0338 155 µM -1.21302066307052 0.114398409509424 no 2990 0.112560960268614 4293 20969351 SGTC_739 1486-1183 203 µM -1.21322470707196 0.11435963185845 no 2991 0.112521960184339 4299 4346692 SGTC_450 aminopyrene 156 nM -1.21335193778188 0.114335456968063 no 2992 0.112497646745347 4255 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3060 1327-0027 12.5 µM -1.21539747640162 0.113947287096338 no 2993 0.112107265035964 4213 16000455 YPR107C YTH1 SGTC_2458 5808907 16.39 µM -1.21624499532848 0.1137867338234 no 2994 0.111945803973564 4434 2731747 SGTC_1354 1498-1681 81 µM -1.21659842365709 0.113719828317373 no 2995 0.111878521397847 4283 5754243 SGTC_1620 st003704 16.5 µM -1.21741549476757 0.113565260595036 no 2996 0.111723085309393 4288 2834414 SGTC_2196 6573537 42.6665 µM -1.21771213636691 0.113509181119571 no 2997 0.111666691729522 4311 2903087 SGTC_3012 9080433 71.4286 µM -1.21911223443818 0.113244762046848 no 2998 0.111400798471222 4297 17688859 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.21938477106757 0.113193342585428 no 2999 0.111349093649668 4292 641818 YHR062C RPP1 SGTC_1684 st024538 14.6195 µM -1.22222674102592 0.112658140695771 no 3000 0.110810947044785 4261 6732859 SGTC_1499 4480-0877 67.3 µM -1.22247624549276 0.1126112402678 no 3001 0.110763790788006 4288 2861909 SGTC_308 4092-1169 104 µM -1.2252856866088 0.112084099873541 no 3002 0.110233799709994 4254 2268590 YDL196W YDL196W SGTC_3 0833-0587 95.581 µM -1.2253042033466 0.112080631406767 no 3003 0.110230312637056 4186 5382644 SGTC_2513 baicalein 25.65 µM -1.22890371962337 0.111407843770789 no 3004 0.10955395335205 4302 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2219 9098279 200 µM -1.23023845076134 0.111159104521107 no 3005 0.109303912544736 4246 902349 SGTC_1174 0739-0097 51.1 µM -1.23270278486061 0.110700898916388 no 3006 0.108843336229774 4349 728447 SGTC_2134 5324836 1.464 µM -1.23404625003493 0.110451672749253 no 3007 0.108592835292543 4270 699272 SGTC_1041 0206-0046 107 µM -1.23637690863479 0.110020267119636 no 3008 0.108159247658505 4308 50494 SGTC_127 0180-0333 59.125 µM -1.23652000845138 0.109993818747717 no 3009 0.108132666530864 4232 771601 SGTC_551 k048-0028 34.9 µM -1.23851129061892 0.109626254085572 no 3010 0.10776326911261 4290 6836383 SGTC_134 0269-0018 6.916 µM -1.23915240612227 0.10950810043045 no 3011 0.107644531166087 4283 4378915 SGTC_1507 4075-3230 155 µM -1.24112514157431 0.109145111089737 no 3012 0.10727976158201 4262 659771 SGTC_1899 st063254 59.6 µM -1.24380473234641 0.108653444209498 no 3013 0.106785719137013 4263 3093813 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.24847054134471 0.10780113992155 no 3014 0.105929394990533 4356 65057 A dermal irritant. YDR527W RBA50 SGTC_743 1275-0778 158 µM -1.24919896520835 0.10766851438544 no 3015 0.10579615519647 4309 2849257 YMR203W TOM40 SGTC_178 4092-0806 87.505 µM -1.25257535562735 0.107055303739617 no 3016 0.105180144156468 4220 2169044 SGTC_3082 9117008 49.47 µM -1.25386181163624 0.106822325144539 no 3017 0.104946118785203 4357 41448529 SGTC_1474 0330-0125 5.35 µM -1.25856437962259 0.105973798135007 no 3018 0.104093859890932 4368 X1474 SGTC_1005 4092-0690 4.4 µM -1.26796119875918 0.104292857199437 no 3019 0.102405903663945 4356 1529343 SGTC_2484 5809818 12.04 µM -1.26975321347528 0.103974500556168 no 3020 0.102086275590525 4301 2870548 SGTC_585 0kpi-0023 191 µM -1.27096857713573 0.103758989073281 no 3021 0.101869913851976 4280 64601 SGTC_655 k060-0012 42 µM -1.27280471668182 0.103434014870981 no 3022 0.101543673525985 4320 5994525 SGTC_631 k072-0230 41.5 µM -1.27798166757771 0.102521737362196 no 3023 0.100627945137953 4339 5773147 SGTC_80 0159-0065 512.242 µM -1.27874788189188 0.102387214293606 no 3024 0.10049292618676 4276 1548079 SGTC_715 0868-0130 184 µM -1.27895189481326 0.10235141770693 no 3025 0.100456998210272 4402 2876258 SGTC_2495 cafestol 54.53 µM -1.27939087493373 0.102274424086687 no 3026 0.100379722793269 4355 16667697 An anti-infammatory. SGTC_2124 5246320 200 µM -1.28399637121795 0.101469194883326 no 3027 0.099571612559839 4367 579342 SGTC_2581 avocatin a 64 µM -1.28517016390733 0.101264708297565 no 3028 0.0993664136463478 4305 6710728 A skin care supplement. SGTC_1470 k295-0292 231 µM -1.28958287809382 0.10049865497595 no 3029 0.0985977618336718 4427 5045612 SGTC_2286 7945697 125 µM -1.28985390571672 0.100451742398378 no 3030 0.0985506937355709 4357 1245733 SGTC_1368 1852-0141 284 µM -1.28994520486985 0.100435942889541 no 3031 0.0985348419436718 4359 2838987 SGTC_111 0083-0039 52.457 µM -1.29070329682691 0.100304823527913 no 3032 0.0984032905186178 4305 759313 SGTC_2658 polymyxin b sulfate 77.05 µM -1.2907473740431 0.100297203790493 no 3033 0.0983956457732614 4386 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2080 5212524 12.4 µM -1.29690613931678 0.0992366722903912 no 3034 0.0973317419355933 4315 260183 SGTC_2108 5365811 200 µM -1.29761172576155 0.0991156966981811 no 3035 0.0972103953972531 4371 780283 SGTC_1997 st073024 93.8 µM -1.298868787557 0.0989004357898373 no 3036 0.0969944814365279 4393 686268 SGTC_472 calcifediol 10 µM -1.3010392849269 0.0985295624916459 no 3037 0.0966225040821715 4414 5283731 A vitamin D metabolite. SGTC_1735 st034310 56.75 µM -1.30348056107321 0.0981136389981385 no 3038 0.0962053743096704 4405 871153 SGTC_3333 9141820 12.094 µM -1.30400606149174 0.0980242772791893 no 3039 0.0961157578369188 4352 1939433 SGTC_2249 haloperidol 116.36 µM -1.30690378516833 0.0975325882942041 no 3040 0.0956226952074718 4325 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_976 1348-1067 47.6 µM -1.30750740651328 0.097430393180373 no 3041 0.0955202205696908 4392 5310671 YGL099W LSG1 SGTC_3100 9120536 49.47 µM -1.30903176138063 0.0971726644783826 no 3042 0.0952617961049335 4247 16421196 SGTC_3218 9131285 49.47 µM -1.31271414374407 0.0965521343236151 no 3043 0.0946396449193316 4362 17156417 SGTC_3161 9100388 49.47 µM -1.31292406437896 0.096516847827988 no 3044 0.0946042685523316 4455 25236368 SGTC_2884 9058502 51.95 µM -1.31300348111836 0.0965035007846343 no 3045 0.0945908875802702 4390 6471554 SGTC_934 2950-0684 338 µM -1.31409254426525 0.0963206059684549 no 3046 0.0944075314334165 4389 1121253 SGTC_908 3448-7491 47.7 µM -1.31477436978048 0.0962062314694433 no 3047 0.0942928718485682 4392 1203031 SGTC_907 3448-6986 75.5 µM -1.31981704680825 0.0953634333632179 no 3048 0.0934480543460856 4407 590582 SGTC_2629 bisabolol 100 µM -1.31990462769932 0.0953488438731684 no 3049 0.0934334311653985 4410 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_43 0570-0105 72.5 µM -1.32381153200849 0.0946996904471765 no 3050 0.0927828226171042 4357 1114046 YDL195W SEC31 SGTC_3225 9130819 49.47 µM -1.32392174594951 0.0946814251584301 no 3051 0.0927645176321704 4344 4547121 SGTC_3270 9137563 49.47 µM -1.32428116412114 0.094621878350843 no 3052 0.0927048418861623 4374 17015724 SGTC_1314 1222-0010 41.1 µM -1.33056338687476 0.0935855216153794 no 3053 0.0916663582254115 4392 3526027 SGTC_2462 5162487 171.77 µM -1.33166215472565 0.0934051261711271 no 3054 0.0914856153222929 4340 2259986 SGTC_1706 st031321 9.9705 µM -1.33374342507433 0.0930641280050181 no 3055 0.0911439789356258 4411 6103185 SGTC_2546 rhodinyl acetate 100 µM -1.33420558664458 0.0929885318276792 no 3056 0.0910682445697732 4339 6708682 SGTC_146 3448-8650 53.125 µM -1.33489330314562 0.0928761254749085 no 3057 0.0909556349593343 4362 2891488 YIL048W NEO1 SGTC_2102 5377816 72.7585 µM -1.33706934203724 0.0925211166783256 no 3058 0.0906000016908105 4446 1379702 SGTC_1597 7-benzyloxygramine 47.5 µM -1.33720512155563 0.0924989983169065 no 3059 0.0905778453026179 4292 260807 SGTC_2163 5671233 125 µM -1.3421283309532 0.0916996522691115 no 3060 0.0897771946490505 4366 701023 SGTC_1101 ebselen 5.29 µM -1.34340350051808 0.0914934490738577 no 3061 0.0895706770137372 4404 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3259 9138485 49.47 µM -1.34634697174841 0.0910187831965201 no 3062 0.0890953220044735 4405 17646153 SGTC_2399 5884133 200 µM -1.34831134369495 0.0907030252709759 no 3063 0.0887791325664479 4360 722445 SGTC_3005 9076496 71.4286 µM -1.35271306620961 0.0899984348002349 no 3064 0.0880736572749807 4376 21368410 SGTC_2106 5357045 167.29 µM -1.35553976049118 0.08954811098848 no 3065 0.0876228248162107 4427 668842 SGTC_408 cantharidin 100 µM -1.35646430484675 0.0894011850668078 no 3066 0.0874757425935932 4375 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1889 st059080 5.18 µM -1.35729491562848 0.0892693397801363 no 3067 0.0873437611063757 4378 176925 Isolated from Daphnopsis sellowiana. SGTC_1692 fluoroquinolonic acid 71 µM -1.35789257871802 0.0891745604996766 no 3068 0.0872488862911714 4417 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3136 9095672 49.47 µM -1.36221584243406 0.0884911927361386 no 3069 0.0865648887748357 4254 17217380 SGTC_1149 3909-7961 23.3 µM -1.36269895474989 0.0884150713643249 no 3070 0.0864887037012968 4466 735261 SGTC_1871 st057448 67.3 µM -1.36690687860764 0.0877541139174699 no 3071 0.0858272478360078 4420 691747 SGTC_262 fenpropimorph 62.5 µM -1.36713167128151 0.0877189087193971 no 3072 0.0857920188521955 4435 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2954 9074818 52.69 µM -1.36728326514211 0.0876951732727594 no 3073 0.085768267527346 4432 16648742 SGTC_1228 0124-0032 52.5 µM -1.36967292412681 0.0873216509673706 no 3074 0.0853945121630542 4452 X1228 SGTC_942 3253-1115 227 µM -1.37066940246931 0.0871662450200913 no 3075 0.0852390185898982 4433 46497897 SGTC_1355 1499-0035 1.68 µM -1.37096469307865 0.0871202326160948 no 3076 0.0851929812976725 4413 1548538 SGTC_2170 morpholine 200 µM -1.37229836815975 0.0869126443114935 no 3077 0.0849852867180005 4454 121171 Reacts with secondary amines. SGTC_50 0929-0078 56.389 µM -1.37475851174701 0.0865306895574589 no 3078 0.0846031622076895 4264 1377751 SGTC_553 k007-0256 45.7 µM -1.37535759624899 0.0864378677137142 no 3079 0.084510304173375 4477 6287000 SGTC_3131 9127911 49.47 µM -1.37584956147876 0.0863616985611372 no 3080 0.0844341068058253 4427 45595681 SGTC_22 0964-0034 14.468 µM -1.38072139322826 0.0856101186046763 no 3081 0.0836823204347316 4423 138402 SGTC_1393 3470-5649 58.2 µM -1.38231749726586 0.0853649549776046 no 3082 0.0834371179011338 4414 4108395 SGTC_130 0136-0219 337.655 µM -1.38463303480756 0.085010220891087 no 3083 0.083082352437923 4256 234244 SGTC_3182 9108849 49.47 µM -1.38537084521869 0.0848974227698314 no 3084 0.0829695505363527 4437 17133045 SGTC_3322 9139058 2.11 µM -1.38786615514237 0.0845167655806311 no 3085 0.0825889027539031 4463 4908926 YPR165W RHO1 SGTC_2094 5332512 191.667 µM -1.39066985578516 0.0840905928169308 no 3086 0.0821627812791609 4457 755774 SGTC_2308 7584454 197.62 µM -1.39160126022294 0.0839493735225506 no 3087 0.082021588522487 4445 893577 SGTC_102 gallobenzophenone 83.616 µM -1.39333834483514 0.0836864731214298 no 3088 0.0817587502298676 4412 70837 SGTC_107 0358-0022 2.6945 µM -1.39507007357536 0.0834249994598611 no 3089 0.0814973547898436 4463 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_699 0375-0592 111 µM -1.39654847725517 0.0832022616124362 no 3090 0.0812746965639646 4509 762578 SGTC_2036 5160441 105 µM -1.39818472251911 0.0829562648204224 no 3091 0.0810288016443635 4402 134534 YIL048W NEO1 SGTC_2182 6325192 200 µM -1.39847038624733 0.0829133736465939 no 3092 0.0809859297341037 4449 736248 SGTC_736 0958-0254 92.6 µM -1.4010262081614 0.0825303700984711 no 3093 0.0806031180355803 4493 6812352 SGTC_1501 4491-0275 38.4 µM -1.40485858840789 0.081958565393859 no 3094 0.0800316664664051 4439 5104718 SGTC_3081 9117243 49.47 µM -1.40555361833082 0.081855185027866 no 3095 0.0799283585209837 4408 45595589 SGTC_3250 9135583 49.47 µM -1.40653063618164 0.081710027340776 no 3096 0.0797833069709409 4458 7699353 SGTC_2435 5706476 10.6 µM -1.40855281193287 0.0814102048401431 no 3097 0.079483720199443 4429 5725375 SGTC_2453 5731132 22.18 µM -1.40991485763977 0.0812087261959447 no 3098 0.0792824124986406 4471 1362040 SGTC_420 mitomycin C 81.9 mM -1.4126267085642 0.0808087001326918 no 3099 0.0788827558349558 4421 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1239 0337-0584 35.4 µM -1.41433473837915 0.0805575127938133 no 3100 0.0786318209355582 4494 914301 YML130C ERO1 SGTC_1118 chelidonine 707.474 nM -1.414600601823 0.0805184673231133 no 3101 0.0785928161290301 4433 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1790 st045711 43.5 µM -1.41845143411787 0.0799545250565557 no 3102 0.0780295041039005 4425 585119 SGTC_3304 9125678 46.087 µM -1.41981817467372 0.0797550899650005 no 3103 0.0778303111889491 4397 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3019 9081971 49.47 µM -1.42174853529596 0.0794740526597573 no 3104 0.0775496323568528 4458 16451803 SGTC_2988 9073640 71.4286 µM -1.42192241308277 0.0794487749840703 no 3105 0.0775243879129506 4473 9102229 SGTC_109 0132-0036 33.701 µM -1.42340395689254 0.0792336406588229 no 3106 0.0773095430437079 4334 67274 A color developer. SGTC_1229 0139-0193 12.2 µM -1.42461399527269 0.0790582589697054 no 3107 0.0771344061172747 4506 3090752 SGTC_1921 5740136 50 µM -1.42707661438476 0.0787022377938435 no 3108 0.0767789061868836 4396 1774243 SGTC_3288 9119690 36.221 µM -1.42837066229487 0.0785156447328841 no 3109 0.0765925994115705 4432 17595618 YKL019W RAM2 SGTC_1833 st055984 71 µM -1.43094728400063 0.0781451120129211 no 3110 0.0762226620237073 4468 676288 SGTC_811 0416-0114 265 µM -1.43784472145766 0.0771597502828417 no 3111 0.0752390585369076 4482 6612453 SGTC_2374 9071832 200 µM -1.4393274112539 0.0769491727233306 no 3112 0.0750288899976493 4397 17381698 SGTC_277 nystatin 15.5 µM -1.44275684653356 0.0764637845671447 no 3113 0.0745444896783426 4474 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2197 6588183 93.1375 µM -1.44939518650639 0.0755308443674304 no 3114 0.0736136260809427 4470 884136 SGTC_1184 1269-1718 139 µM -1.45093597000535 0.0753155508545789 no 3115 0.073398845316994 4518 5403821 SGTC_1861 st057647 17.4 µM -1.45332814361944 0.0749822200724985 no 3116 0.0730663334101496 4506 688668 SGTC_2932 9016711 44.54 µM -1.45396320332089 0.074893918731984 no 3117 0.0729782541030203 4451 7117328 SGTC_1650 st011916 45.8 µM -1.45559363345773 0.074667580222072 no 3118 0.0727524945261708 4425 242528 SGTC_2881 9058953 51.95 µM -1.4571104137718 0.0744574877796058 no 3119 0.0725429521234034 4419 17122249 SGTC_1206 3978-0017 132 µM -1.45971521395591 0.0740977448039549 no 3120 0.0721841794148879 4512 3873677 SGTC_2031 5180455 200 µM -1.46861302924434 0.0728788979740584 no 3121 0.0709688894217901 4460 29949 SGTC_920 mycophenolic acid 780.421 nM -1.47199676949715 0.0724194334976132 no 3122 0.0705108749722483 4458 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2759 disulfiram 3.38 µM -1.47311754957136 0.0722677375653759 no 3123 0.0703596710429873 4387 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1943 st076331 65.2 µM -1.47460113253815 0.0720673114541395 no 3124 0.0701599051271532 4471 24208415 SGTC_1057 3448-5381 134 µM -1.48065336042264 0.0712540924949795 no 3125 0.0693494841303857 4450 5497911 SGTC_2254 7938975 95.19 µM -1.4830721561619 0.0709310638680293 no 3126 0.0690276204162217 4515 2969277 SGTC_320 4092-0846 5.34 µM -1.48417687426966 0.0707839041996118 no 3127 0.0688810015970484 4456 1359356 SGTC_2069 5228469 200 µM -1.49900987454439 0.068830648331478 no 3128 0.0669355351927395 4497 2835210 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.50318594970764 0.0682882955184342 no 3129 0.0663955498290733 4457 1241132 A phosphatase inhibitor. SGTC_1942 st076330 65.2 µM -1.50816075023786 0.0676465223057162 no 3130 0.0657566950221668 4545 24208414 SGTC_2000 st075254 36.4 µM -1.50856185457294 0.067594981599048 no 3131 0.0657053942324196 4381 17234175 SGTC_1008 4106-0037 6 µM -1.50877863079608 0.0675671391361513 no 3132 0.06567768171758 4521 2905394 SGTC_3220 9131269 49.47 µM -1.50931887544488 0.0674977893608 no 3133 0.0656086566661458 4509 17722206 SGTC_382 3229-0966 23.2 µM -1.51168265642155 0.0671950037448507 no 3134 0.0653073064166073 4540 5722370 SGTC_2060 5238662 140 µM -1.51255374639388 0.0670836877408781 no 3135 0.0651965253313346 4468 790130 SGTC_2314 7727897 200 µM -1.51711646409756 0.066502949466287 no 3136 0.0646186410724554 4476 900724 SGTC_515 4092-1064 102 µM -1.51825620864422 0.0663584931630592 no 3137 0.0644749112845473 4480 717353 SGTC_2913 7966556 36.57 µM -1.5239630285137 0.0656388367007663 no 3138 0.0637589735353927 4406 2976516 SGTC_2228 7354201 200 µM -1.52662121956703 0.0653056989832777 no 3139 0.0634276136867712 4601 753451 SGTC_2225 6654152 15.4 µM -1.53329544471033 0.0644750331671017 no 3140 0.0626015382481326 4460 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3094 9117742 49.47 µM -1.53424565738986 0.0643574413820722 no 3141 0.062484614581636 4474 17149698 SGTC_1794 st048918 76.9 µM -1.53610905024445 0.0641273246333939 no 3142 0.0622558185009134 4488 672303 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.53808275702905 0.0638842829381997 no 3143 0.0620141907192582 4512 688662 SGTC_2493 resveratrol 26.09 µM -1.54301003613032 0.0632806657589473 no 3144 0.0614141704335103 4478 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1999 st074831 12.5 µM -1.54575256405843 0.0629466207231502 no 3145 0.0610821686050253 4498 17112523 SGTC_53 0973-0023 39.979 µM -1.5544657953046 0.0618944428226819 no 3146 0.0600366747385967 4432 674768 SGTC_2701 st077767 14.721 µM -1.56065738765335 0.0611551483995975 no 3147 0.0593023052687384 4489 5721188 SGTC_2379 9035213 200 µM -1.56249080610904 0.0609375622850478 no 3148 0.059086205033928 4532 646551 SGTC_1322 1348-1070 12 µM -1.56565480479232 0.0605634898424036 no 3149 0.0587147261165919 4525 6758089 SGTC_1153 4055-0057 267 µM -1.56585612198999 0.0605397494859885 no 3150 0.0586911520285215 4564 882706 SGTC_1085 doxorubicin 7.67 µM -1.56746855916857 0.0603498652235068 no 3151 0.058502604848294 4530 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1583 clindamycin 39.6 µM -1.57230498096362 0.0597831122033366 no 3152 0.0579399192194293 4506 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_104 0074-0074 590.992 µM -1.5723790139439 0.0597744692098569 no 3153 0.0579313391460822 4390 3943124 SGTC_3235 9132602 49.47 µM -1.5745927053131 0.0595164834002681 no 3154 0.0576752438573505 4512 4912240 SGTC_1117 retinoic acid 1.10837 µM -1.57905302840689 0.0589993242786181 no 3155 0.0571619471745147 4567 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1346 1488-2224 62.4 µM -1.58060955112153 0.0588196829097162 no 3156 0.0569836703120638 4548 3722427 SGTC_319 1348-1596 45.5 µM -1.58127544624701 0.0587429618538041 no 3157 0.0569075356157643 4586 5380505 SGTC_2832 7992762 51.95 µM -1.58172267484303 0.0586914785502777 no 3158 0.0568564469992065 4461 2985177 SGTC_2764 methyldopa 94.69 µM -1.5840414079261 0.0584251221858621 no 3159 0.0565921482058383 4503 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3198 9112019 49.47 µM -1.58440136902726 0.058383858167966 no 3160 0.0565512052922749 4580 45595555 SGTC_1561 5-methoxyflavone 52.9 µM -1.58442641763266 0.0583809875816524 no 3161 0.0565483570674622 4504 94525 SGTC_1854 st056233 32.9 µM -1.58975193304547 0.0577731930942982 no 3162 0.0559453662229199 4477 5393174 SGTC_653 0203-0016 55.2 µM -1.59074800392482 0.0576600670058302 no 3163 0.0558331494505907 4598 295302 SGTC_2211 7117706 200 µM -1.59127661202053 0.0576001025463218 no 3164 0.0557736689391545 4515 822771 SGTC_878 0828-0289 13.7 µM -1.59650878331869 0.0570092153780248 no 3165 0.0551876231698223 4505 745350 YLR208W SEC13 SGTC_2023 5144124 124 µM -1.5967844480333 0.0569782164477508 no 3166 0.0551568818832952 4502 2830192 SGTC_2353 9059630 146.67 µM -1.60344681439519 0.0562330517392577 no 3167 0.0544180212270249 4584 4779114 SGTC_3061 glucosamine 200 µM -1.60821423416142 0.055704562900588 no 3168 0.0538941333776533 4490 91431 and experimental redox chemotherapeutic SGTC_1653 st012112 65 µM -1.61157513096834 0.0553343545126856 no 3169 0.05352721299055 4524 720429 SGTC_2457 5731572 11.68 µM -1.61220681737852 0.0552649906024057 no 3170 0.0534584711310929 4598 2865357 SGTC_2301 7769476 200 µM -1.62316614697999 0.0540724719313181 no 3171 0.0522769462302325 4547 977820 SGTC_3272 9137413 49.47 µM -1.62561865242178 0.0538084164289433 no 3172 0.0520154023808065 4494 17614870 SGTC_1810 st050138 53 µM -1.62721925010147 0.0536366352238754 no 3173 0.0518452703600763 4564 3444541 SGTC_757 1066-0008 322 µM -1.62741156237442 0.0536160249280907 no 3174 0.0518248587425349 4568 6842497 SGTC_2317 5986382 200 µM -1.62741446735505 0.0536157136465605 no 3175 0.051824550463014 4573 877883 SGTC_2935 9038016 29.96 µM -1.63012415866954 0.0533259811531179 no 3176 0.05153762937128 4514 6463195 SGTC_1070 indatraline 8.81 µM -1.63511892875006 0.0527951707700813 no 3177 0.0510120594145344 4599 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3162 9099653 49.47 µM -1.63646437056334 0.0526529053079155 no 3178 0.0508712183353909 4541 25237511 SGTC_2398 5228213 48.84 µM -1.64084464320953 0.0521918468358206 no 3179 0.0504148342411187 4509 80771 YMR134W ERG29 SGTC_2621 lithochol-11-enic acid 100 µM -1.64265356072482 0.0520023819090156 no 3180 0.0502273161121558 4513 6708711 SGTC_1815 st051655 58.2 µM -1.64387598224423 0.0518746559198743 no 3181 0.0501009111118207 4521 5984156 SGTC_496 calpeptin 138 µM -1.65529527201696 0.0506935068832436 no 3182 0.0489323087661951 4555 73364 A calpain inhibitor. SGTC_2918 7977171 22.06 µM -1.66505730725639 0.0497008454095863 no 3183 0.0479506615730383 4563 2236483 SGTC_2356 9061756 188.97 µM -1.67059286380142 0.0491448852086951 no 3184 0.0474010615000025 4603 20104043 SGTC_852 0418-0143 439 µM -1.67720133843587 0.0484876838680085 no 3185 0.0467515587091696 4557 5369229 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.67941053165503 0.0482695574329639 no 3186 0.0465360310825518 4516 17037758 SGTC_2879 9041815 71.43 µM -1.68905041507999 0.0473269263986554 no 3187 0.0456048844833556 4627 4942971 SGTC_1411 3909-8223 150 µM -1.68919663707335 0.0473127425594798 no 3188 0.045590876627642 4622 X1411 SGTC_110 0850-0284 111.64 µM -1.691849571629 0.0470559934749187 no 3189 0.0453373295505534 4529 3906265 SGTC_285 1486-1325 46 µM -1.69622838369748 0.046634659993159 no 3190 0.0449213185593794 4619 22310230 SGTC_3091 9116372 49.47 µM -1.6975955430143 0.0465037325058742 no 3191 0.0447920623075506 4616 17169793 SGTC_2721 ifenprodil 61.44 µM -1.700312840553 0.0462443835610768 no 3192 0.0445360482160926 4572 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2750 bromebric acid 70.15 µM -1.70623473260918 0.0456831998092469 no 3193 0.0439821922136297 4574 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3006 9075424 71.4286 µM -1.71049726787744 0.045282662205335 no 3194 0.0435869791111208 4562 7465181 SGTC_1413 3910-0535 34.4 µM -1.71057001934146 0.0452758505690695 no 3195 0.0435802587101295 4615 2876951 SGTC_3197 9113331 49.47 µM -1.71095166211519 0.0452401312959447 no 3196 0.0435450182388219 4566 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1760 st045453 10.4495 µM -1.71131122777533 0.0452064990420485 no 3197 0.0435118373899043 4593 3323419 YIL048W NEO1 SGTC_59 0330-0160 1.33 µM -1.71367062627299 0.0449863096629355 no 3198 0.0432946172477758 4546 4293482 SGTC_473 2-arachidonoylglycerol 10 µM -1.71746276156489 0.0446342205371672 no 3199 0.042947326391478 4458 5282280 An endocannabinoid. SGTC_2437 5741531 144.16 µM -1.71939988551912 0.0444552223818114 no 3200 0.0427707915393187 4605 2262990 SGTC_129 0088-0017 176.636 µM -1.73089518478373 0.043404877463277 no 3201 0.041735230310014 4469 182446 SGTC_1632 st005650 90 µM -1.7310142344486 0.0433941054372389 no 3202 0.0417246128467587 4614 2759605 SGTC_1975 st070967 30.8 µM -1.73290517719375 0.0432232956135419 no 3203 0.0415562619715941 4599 261391 SGTC_2303 7774051 200 µM -1.73572562100085 0.0429695328609237 no 3204 0.0413061805101691 4589 2953184 SGTC_1974 st069448 26.9 µM -1.73647281755126 0.0429025077006181 no 3205 0.0412401333170154 4598 6323587 YNR016C ACC1 SGTC_3137 9097352 49.47 µM -1.73671024915091 0.0428812272654224 no 3206 0.0412191638804661 4573 44120435 SGTC_180 1486-1293 102.781 µM -1.73837741587947 0.0427320431673086 no 3207 0.0410721667140444 4533 4140536 SGTC_1241 0364-0022 50.8 µM -1.74198557442358 0.0424106086160266 no 3208 0.0407554842530296 4612 4563895 SGTC_1061 3448-9325 110 µM -1.74574018179041 0.0420782068697941 no 3209 0.0404280547438314 4572 723482 SGTC_828 2074-0507 139 µM -1.74753005190285 0.0419204905069659 no 3210 0.0402727183639628 4637 X828 SGTC_2846 9008642 19.48 µM -1.76655148333441 0.0402737949432405 no 3211 0.0386516861496969 4608 2992898 SGTC_1647 st011722 22.4 µM -1.7749597293166 0.0395628269072266 no 3212 0.0379522683901321 4617 2854783 SGTC_2243 6634756 200 µM -1.77658231051021 0.0394268098707368 no 3213 0.0378184941190905 4628 885676 SGTC_1927 st060202 13.8 µM -1.77758372518443 0.0393430537315417 no 3214 0.0377361243504391 4561 688887 SGTC_2625 euphol 100 µM -1.78203094614876 0.0389728452914566 no 3215 0.0373720926857402 4617 6708538 A triterpene alcohol. SGTC_3166 9102297 49.47 µM -1.78580311420842 0.0386610594118092 no 3216 0.0370655711633796 4633 25237072 SGTC_1711 st032263 62.8 µM -1.7890418389496 0.0383949891538216 no 3217 0.0368040388607503 4620 3958979 SGTC_1951 sophoraflavanone G 9.2 µM -1.78995192328848 0.0383204924395021 no 3218 0.0367308202763247 4570 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1434 4073-0095 163 µM -1.79211769473534 0.0381436828818745 no 3219 0.0365570575097901 4646 24133745 SGTC_1211 1056-0033 32.3 µM -1.79578633231176 0.0378457006049545 no 3220 0.036264252633221 4652 6741922 SGTC_645 0845-0943 5.41 µM -1.79776727748756 0.0376855913481599 no 3221 0.0361069474502459 4641 1885106 SGTC_1058 3448-5425 97.3 µM -1.80258723056802 0.0372983288520513 no 3222 0.0357265319658452 4585 7279705 SGTC_430 0958-0115 16.4 µM -1.80765872668003 0.0368943722643672 no 3223 0.0353298160103272 4561 6833180 SGTC_3327 9140648 26.9345 µM -1.80987410265018 0.0367190384414561 no 3224 0.0351576565114427 4642 8029710 SGTC_1112 tnp00069 1.16933 µM -1.80997549806806 0.0367110299352875 no 3225 0.0351497934543192 4613 145826 SGTC_1813 st051246 8.6015 µM -1.81101856314773 0.0366287285207391 no 3226 0.0350689891148153 4594 5291959 SGTC_471 1-acyl-paf 4 µM -1.81847328008754 0.0360449103464148 no 3227 0.0344959135096022 4608 16759367 SGTC_2413 inermin 26.06 µM -1.81967557222888 0.0359514700756893 no 3228 0.0344042127325093 4642 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_5 0352-0601 109.883 µM -1.83271184585522 0.0349509953609282 no 3229 0.0334227173600436 4547 762456 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.83271489999293 0.0349507636752504 no 3230 0.0334224901454562 4652 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2393 9031399 185.94 µM -1.83801031201545 0.0345509475865617 no 3231 0.0330304429006691 4620 1526623 YDL150W RPC53 SGTC_1003 4049-0218 100 µM -1.84004740564451 0.0343981462819568 no 3232 0.0328806389136684 4643 295161 SGTC_2870 9038528 12.99 µM -1.84129424183464 0.0343048960201814 no 3233 0.0327892255521851 4649 6463316 SGTC_3045 9092950 49.47 µM -1.84353365324771 0.0341379332762185 no 3234 0.0326255664304977 4609 44120432 SGTC_2611 pyromycin 23.93 µM -1.85805738759748 0.0330712419565311 no 3235 0.0315804326282018 4586 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1168 k815-0004 80.5 µM -1.86044622847154 0.0328984524112493 no 3236 0.0314112097003369 4646 642433 SGTC_870 0573-2213 57.6 µM -1.86385587738191 0.0326531154641111 no 3237 0.0311709731663455 4643 3916321 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.87263136096574 0.0320286186110954 no 3238 0.0305596538084476 4650 2333 A French combination drug. SGTC_2160 5660466 132.927 µM -1.87634285912063 0.03176747828777 no 3239 0.030304107705318 4610 2859134 SGTC_3003 9075612 71.4286 µM -1.87838964798682 0.0316242207343242 no 3240 0.0301639403197317 4661 6501993 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.88580634832714 0.031109581245992 no 3241 0.0296605275771093 4586 5355888 SGTC_3295 9122362 53.5725 µM -1.88854131600015 0.030921560931759 no 3242 0.0294766583792235 4638 4730473 SGTC_882 0843-0131 351 µM -1.88902492755655 0.0308884122311655 no 3243 0.0294442443066783 4673 5425421 SGTC_628 1636-0253 16 µM -1.89044348578868 0.03079134812364 no 3244 0.0293493360883493 4654 4456143 SGTC_2227 7312221 64.1025 µM -1.90428757920129 0.0298572656514765 no 3245 0.0284363704902783 4730 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2103 5378138 10 µM -1.90534128649102 0.0297871434764432 no 3246 0.0283678609812613 4707 244142 SGTC_2676 harmalol 100 µM -1.91352580247972 0.0292471191410407 no 3247 0.0278403867700099 4654 5459187 A monoamine oxidase inhibitor SGTC_2452 5863136 48.41 µM -1.91409816521128 0.0292096601453423 no 3248 0.0278038069660091 4624 2184096 SGTC_1303 1160-0052 261 µM -1.91514949221556 0.0291409585614131 no 3249 0.027736720800491 4627 3562476 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.91611173203573 0.0290781963140544 no 3250 0.0276754376483987 4661 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1704 st028805 70.8 µM -1.91973436475405 0.0288429160457196 no 3251 0.0274457305912975 4690 2876101 SGTC_2875 9039966 71.43 µM -1.92231566457764 0.0286762349093959 no 3252 0.0272830250586482 4673 6463691 SGTC_1511 0906-3109 28.5 µM -1.92444642563003 0.0285392504399074 no 3253 0.0271493249694051 4661 2882180 SGTC_621 3584-0052 32.1 µM -1.9252799344168 0.0284858133230459 no 3254 0.0270971732757076 4696 2273927 SGTC_850 0388-0143 75.9 µM -1.92576756395348 0.0284545894979759 no 3255 0.0270667016297443 4674 67273 SGTC_213 1246-0773 967 nM -1.92653219038453 0.0284056863828379 no 3256 0.0270189782104806 4680 6251622 SGTC_829 1635-0120 117 µM -1.92703320009709 0.028373681308182 no 3257 0.026987746273106 4646 285054 SGTC_2674 ligustilide 100 µM -1.93337420069267 0.0279711978547395 no 3258 0.0265950585382002 4702 5319022 A signalling regulator. SGTC_1465 k213-0056 144 µM -1.93579314892941 0.0278189177175613 no 3259 0.026446520176951 4603 24048857 YMR208W ERG12 SGTC_2942 9052777 62.25 µM -1.93915580820199 0.0276083761366674 no 3260 0.0262411844202752 4672 6469503 SGTC_2947 9072639 7.68 µM -1.944688575806 0.0272648517971063 no 3261 0.0259062356681032 4611 16488146 SGTC_2334 9017922 200 µM -1.94821479939078 0.0270477778195019 no 3262 0.0256946333623294 4665 3163164 SGTC_273 hydroxyurea 18.1 mM -1.95758863397864 0.0264777292069686 no 3263 0.0251391510632866 4709 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3158 9100007 49.47 µM -1.96105348584228 0.0262695790843363 no 3264 0.0249363919708615 4680 19297233 SGTC_1426 4048-4480 71.7 µM -1.96157462471385 0.0262383904598026 no 3265 0.024906014487908 4689 14224343 SGTC_2719 novobiocin 32.65 µM -1.96500193818286 0.0260340462487235 no 3266 0.0247070066094999 4685 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3203 9113543 49.47 µM -1.97489987439859 0.0254513688341171 no 3267 0.0241397558340928 4669 17018012 SGTC_1106 tegaserod maleate 11.7 µM -1.98060166722017 0.0251206985580391 no 3268 0.023817980915849 4688 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1208 2323-2347 50.3 µM -1.98728823125978 0.0247375122862872 no 3269 0.0234452325460122 4680 5412760 SGTC_361 000s-0510 1.45 µM -1.9909975019984 0.0245270681530138 no 3270 0.0232405809381116 4598 660 SGTC_832 4083-0019 164 µM -1.99529070074394 0.0242853730777377 no 3271 0.0230055917728746 4711 1990758 SGTC_2905 7799065 20.05 µM -1.99648594517419 0.0242184411734109 no 3272 0.0229405270485612 4601 1296806 SGTC_1928 4'-methoxychalcone 40.3 µM -2.00578697825727 0.0237028726248208 no 3273 0.0224394902820065 4673 641818 SGTC_358 0075-0058 9.45 µM -2.03014749700575 0.0223961074995419 no 3274 0.0211707743915745 4638 1069125 SGTC_407 eburnamonine 100 µM -2.03314291041841 0.0222397018828184 no 3275 0.021019043416109 4575 3195 SGTC_777 1315-0167 517 µM -2.03391385462143 0.0221995964560451 no 3276 0.0209801409087727 4705 4221767 SGTC_705 1124-0212 310 µM -2.03456116775397 0.0221659696128509 no 3277 0.0209475240090926 4678 9554485 SGTC_1558 st069300 45.6 µM -2.0402830686416 0.0218705914274216 no 3278 0.0206610700924699 4688 24208000 SGTC_2074 5212007 75.395 µM -2.04331196478585 0.0217155826961521 no 3279 0.0205107829643532 4657 758611 SGTC_2851 9015922 71.43 µM -2.04369051080811 0.0216962753871144 no 3280 0.0204920656220875 4683 2996893 SGTC_406 estrone 100 µM -2.05018494565339 0.0213672862994719 no 3281 0.0201731932444321 4683 5870 A steroid. SGTC_2003 4023581 200 µM -2.05889710342096 0.0209325863932608 no 3282 0.0197520483184303 4674 16641307 SGTC_39 0986-0283 58.349 µM -2.07572170085412 0.0201142749555604 no 3283 0.0189598488425108 4706 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2256 7954252 200 µM -2.08032906283824 0.0198949732629794 no 3284 0.0187476804226922 4706 2972920 SGTC_2872 9044037 25.97 µM -2.0889473376036 0.019490204596148 no 3285 0.0183562319825742 4742 6465195 SGTC_1976 st070609 63.5 µM -2.08946200650629 0.0194662554426931 no 3286 0.0183330772958674 4678 682556 SGTC_219 mitoxanthrone 164.414 µM -2.09387670645103 0.0192618506389026 no 3287 0.0181354823895565 4691 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_79 0052-0007 94.094 µM -2.09642487404904 0.0191447005074337 no 3288 0.0180222588877056 4694 2801472 SGTC_2064 5220758 200 µM -2.10005313222487 0.0189789396538021 no 3289 0.0178620837468759 4705 788518 SGTC_2126 5251174 33.877 µM -2.10766419483067 0.0186351830190814 no 3290 0.0175300232497975 4676 790722 SGTC_1301 naphtanilide LB 4.81 µM -2.12557958786189 0.0178468918328069 no 3291 0.0167691403579875 4737 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2059 5238311 157 µM -2.13347828035427 0.0175084829242089 no 3292 0.0164427557605474 4682 703021 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.14107082802702 0.0171883694769754 no 3293 0.0161341633789628 4697 1377 SGTC_480 am 92016 50 µM -2.14128250788538 0.0171795168621179 no 3294 0.0161256314306459 4715 2129 K+ channel blocker. SGTC_1945 st075991 56.6 µM -2.1585964398311 0.0164685060661461 no 3295 0.0154407446028033 4703 1084980 SGTC_3229 9132204 49.47 µM -2.16637650534441 0.0161573068158666 no 3296 0.0151412139063844 4772 17682924 SGTC_1750 st081859 2.357 µM -2.17495875228893 0.0158198785747529 no 3297 0.0148166037574653 4641 5291695 SGTC_2718 lomofungin 53.02 µM -2.18645493923178 0.0153773655378268 no 3298 0.0143911689753605 4689 5351222 A RNA synthesis inhibitor. SGTC_2278 7948257 134.34 µM -2.19238094997414 0.0151534413566102 no 3299 0.0141760054998463 4727 1247028 SGTC_1655 st012546 55.1 µM -2.2155731205221 0.0143038204891808 no 3300 0.0133603757175415 4726 720985 YLR208W SEC13 SGTC_2606 farnesol 9.78 µM -2.23712108429083 0.013551524399829 no 3301 0.0126392136437005 4696 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2337 9009472 200 µM -2.25673249983118 0.0128967726568833 no 3302 0.0120123973891779 4678 5742383 SGTC_2017 5132927 60.65 µM -2.27004419008264 0.0124680928834742 no 3303 0.0116024509964046 4701 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3347 9188721 44.724 µM -2.28879603429076 0.0118851823445441 no 3304 0.0110456030039791 4716 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2906 7926292 26.41 µM -2.30938691210894 0.0112724780650613 no 3305 0.0104610603177971 4726 2966319 SGTC_761 k216-0224 480 µM -2.30961591423154 0.0112658211819641 no 3306 0.0104547138756754 4743 1340404 SGTC_2769 toremifene 3.73 µM -2.31677730617643 0.0110593632241597 no 3307 0.0102579329353136 4735 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2077 5212015 200 µM -2.33904327855481 0.0104383315987633 no 3308 0.00966659688109995 4715 780900 SGTC_763 3453-1109 128 µM -2.34684997960394 0.0102279043026785 no 3309 0.00946643805812481 4752 1560353 SGTC_1868 st057644 42.7 µM -2.37224705182281 0.00956872004134732 no 3310 0.00884013223154991 4757 688665 SGTC_81 0411-0046 9.971 µM -2.38091817246947 0.0093523241108784 no 3311 0.00863477380193767 4766 12925265 SGTC_992 3909-8734 162 µM -2.40537130810094 0.00876497058515892 no 3312 0.00807802057873747 4763 4288319 SGTC_526 4469-0568 170 µM -2.42441025697827 0.00833030777448365 no 3313 0.00766663628687905 4740 2901964 SGTC_883 0850-0245 24.6 µM -2.42708905625132 0.00827069463270451 no 3314 0.00761025957464627 4760 6823229 YPR165W RHO1 SGTC_3294 9122953 26.2835 µM -2.43190262024418 0.00816451616153938 no 3315 0.00750987242280848 4736 16459826 SGTC_428 3448-4153 16.5 µM -2.44270544927849 0.0079305753187118 no 3316 0.00728881481481617 4733 3834874 SGTC_476 mead acid 10 µM -2.45384601366288 0.00769551497661447 no 3317 0.00706687451213796 4789 5312531 An omega 9 fatty acid. SGTC_650 1328-0195 38 µM -2.45712357780052 0.00762753775649989 no 3318 0.00700272498553864 4752 2780821 SGTC_1556 plumbagin 1.48 µM -2.4629000864552 0.0075090182441417 no 3319 0.00689091575465604 4722 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2323 6148992 148.28 µM -2.49334796292372 0.006910730200928 no 3320 0.0063272382819909 4730 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3173 9105693 49.47 µM -2.49582231173307 0.00686401225376923 no 3321 0.00628327662471185 4744 17096658 SGTC_1693 xanthone 101.9 µM -2.49874601731104 0.00680916973108782 no 3322 0.00623167999488445 4787 7020 An insecticide. SGTC_158 k038-0087 26.446 µM -2.52680898803529 0.0063021437704234 no 3323 0.00575520432739004 4708 X158 SGTC_1432 4049-0298 68.4 µM -2.53900386000317 0.00609243600593523 no 3324 0.00555842983599049 4784 741646 SGTC_2198 6589944 200 µM -2.54147589938216 0.0060506875855448 no 3325 0.00551927780569519 4779 5290268 SGTC_1035 k081-0041 55.2 µM -2.56271502841319 0.0057023169339497 no 3326 0.00519286269165747 4764 731709 SGTC_502 l-744,832 89.3 µM -2.60758244694228 0.00502434900173558 no 3327 0.00455920542613042 4779 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2336 9001819 198.65 µM -2.69530211893071 0.00390277945813104 no 3328 0.00351624173833451 4756 2989602 SGTC_2912 7964298 10.93 µM -2.69547469246757 0.00390081421908791 no 3329 0.00351442084797118 4763 2975850 SGTC_1878 temozolomide 1 mM -2.71170610707703 0.00371988981935861 no 3330 0.00334689560939265 4779 5394 DNA alkylating agent. SGTC_830 4076-0286 57.8 µM -2.76690151111161 0.00315961191944938 no 3331 0.00282959245873868 4796 6866659 SGTC_2014 4013930 200 µM -2.79150857052895 0.00293526973819555 no 3332 0.00262314841160508 4758 64556 SGTC_1697 st025554 27.742 µM -2.80176367722867 0.00284609077219294 no 3333 0.00254120444930858 4793 1269519 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.80177916677561 0.00284595794307423 no 3334 0.0025410824493628 4804 5357218 A potent inhibitor of glutathione S-transferases. SGTC_365 0121-0052 13.6 µM -2.81132846357069 0.00276512520528038 no 3335 0.00246686953128998 4764 3101739 SGTC_3147 9097027 49.47 µM -2.82159226815703 0.00268055971881148 no 3336 0.00238929444932809 4782 25236841 SGTC_3331 9141060 1.957 µM -2.8375954642859 0.00255335847777113 no 3337 0.00227273758648 4764 4906567 YPR165W RHO1 SGTC_2623 humulene 100 µM -2.86576618911418 0.00234263183195229 no 3338 0.00208000684379584 4766 6187145 An anti-inflammatory. SGTC_276 colchicine 750 µM -2.89353773205064 0.00215043000326406 no 3339 0.00190464259614657 4797 2833 A microtubule depolymerizer. SGTC_3312 9133330 71.43 µM -2.9118907111176 0.00203138085545302 no 3340 0.00179624152809727 4788 17617324 SGTC_759 3486-0358 89.3 µM -2.96816009526829 0.00170271824834592 no 3341 0.00149794122990481 4781 875103 SGTC_2333 9017922 200 µM -2.98773545851311 0.00160025483737942 no 3342 0.00140526354830019 4770 3163164 SGTC_84 0443-0269 128.823 µM -2.98976913110563 0.00158993877190288 no 3343 0.00139594188302542 4788 6150058 SGTC_540 1187-0821 17.3 µM -3.11690535850153 0.00105338949828907 no 3344 0.000913801166595045 4782 847520 SGTC_1519 esterone 74 µM -3.19089322968603 0.000823442257744686 yes 3345 0.000709168422726345 4796 698 A steroid. SGTC_497 capsazepine 133 µM -3.27066421617666 0.000627934476037254 yes 3346 0.000536476134032641 4790 2733484 A calcium channel blocker. SGTC_1747 st037496 66.6 µM -3.33903573496595 0.000495483366295321 yes 3347 0.000420348743631158 4772 723305 SGTC_1881 5652484 16 µM -3.35692064694878 0.000465385170131536 yes 3348 0.000394078647269476 4798 2255129 SGTC_1880 MG-132 525 µM -3.39870579719934 0.000401545415426762 yes 3349 0.000338527520543288 4787 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2784 7567673 72.73 µM -3.41032615628355 0.000385294216584603 yes 3350 0.000324426171534287 4774 3471247 SGTC_2190 6049624 200 µM -3.54459405610875 0.000236926321515257 yes 3351 0.000196609090720197 4795 2265554 SGTC_536 3852-0578 10.6 µM -3.56525048252479 0.000219529080829356 yes 3352 0.000181754426000361 4797 2869208 SGTC_529 4076-0302 30.3 µM -3.59448151909486 0.000196939734730747 yes 3353 0.000162519107453763 4802 5816522 SGTC_2405 ticlatone 3.52 µM -3.83806100462201 7.73004659965215e-05 yes 3354 6.20048386543555e-05 4753 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1953 st076800 12.1 µM -4.05874380576732 3.1609124397495e-05 yes 3355 2.46687026315936e-05 4802 297591 SGTC_535 2293-4129 48.2 µM -4.46915384683468 5.3173768914248e-06 yes 3356 3.92648170086789e-06 4804 396118 YIL048W NEO1